data_9BZG
# 
_entry.id   9BZG 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BZG         pdb_00009bzg 10.2210/pdb9bzg/pdb 
WWPDB D_1000284442 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-01-15 ? 
2 'Structure model' 1 1 2025-01-22 ? 
3 'Structure model' 1 2 2025-03-05 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Database references' 
2 3 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
3 3 'Structure model' citation        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_CSD'          
4  2 'Structure model' '_citation.journal_id_ISSN'         
5  2 'Structure model' '_citation.pdbx_database_id_DOI'    
6  2 'Structure model' '_citation.pdbx_database_id_PubMed' 
7  2 'Structure model' '_citation.title'                   
8  2 'Structure model' '_citation.year'                    
9  2 'Structure model' '_citation_author.name'             
10 3 'Structure model' '_citation.journal_volume'          
11 3 'Structure model' '_citation.page_first'              
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BZG 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-24 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
3 daharki@umn.edu  Daniel   Harki    D 'principal investigator/group leader' 0000-0001-5950-931X 
4 nml@umn.edu      Nicholas Levinson M 'principal investigator/group leader' 0000-0003-4338-8087 
5 aihar001@umn.edu Hideki   Aihara   ? 'principal investigator/group leader' 0000-0001-7508-6230 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Baker, Z.D.'    1 0000-0001-7732-9566 
'Tang, J.'       2 0000-0002-7611-7390 
'Shi, K.'        3 0000-0001-9458-5019 
'Aihara, H.'     4 0000-0001-7508-6230 
'Levinson, N.M.' 5 0000-0003-4338-8087 
'Harki, D.A.'    6 0000-0001-5950-931X 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Cell Chem Biol' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2451-9456 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            32 
_citation.language                  ? 
_citation.page_first                352 
_citation.page_last                 ? 
_citation.title                     'Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.chembiol.2024.12.006 
_citation.pdbx_database_id_PubMed   39778578 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Tang, J.'       1  ? 
primary 'Moorthy, R.'    2  ? 
primary 'Hirsch, L.E.'   3  ? 
primary 'Demir, O.'      4  ? 
primary 'Baker, Z.D.'    5  ? 
primary 'Naumann, J.A.'  6  ? 
primary 'Jones, K.F.M.'  7  ? 
primary 'Grillo, M.J.'   8  ? 
primary 'Haefner, E.S.'  9  ? 
primary 'Shi, K.'        10 ? 
primary 'Levy, M.J.'     11 ? 
primary 'Gupta, H.B.'    12 ? 
primary 'Aihara, H.'     13 ? 
primary 'Harris, R.S.'   14 ? 
primary 'Amaro, R.E.'    15 ? 
primary 'Levinson, N.M.' 16 ? 
primary 'Harki, D.A.'    17 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Aurora kinase A'                                                                                     32980.637 
1   2.7.11.1 'C290A, C393S' ? ? 
2 non-polymer syn '7-cyclopentyl-N,N-dimethyl-2-[4-(methylcarbamoyl)anilino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide' 406.481   
1   ?        ?              ? ? 
3 water       nat water                                                                                                 18.015    
132 ?        ?              ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
;Aurora 2,Aurora/IPL1-related kinase 1,ARK-1,Aurora-related kinase 1,Breast tumor-amplified kinase,Ipl1- and aurora-related kinase 1,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase Ayk1,Serine/threonine-protein kinase aurora-A
;
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   yes 
_entity_poly.pdbx_seq_one_letter_code       
;GAMESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYG
YFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWS
VHAPSSRRT(TPO)LAGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTE
GARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNSQNKESASKQS
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GAMESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYG
YFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWS
VHAPSSRRTTLAGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARD
LISRLLKHNPSQRPMLREVLEHPWITANSSKPSNSQNKESASKQS
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 '7-cyclopentyl-N,N-dimethyl-2-[4-(methylcarbamoyl)anilino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide' OG0 
3 water                                                                                                 HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   ALA n 
1 3   MET n 
1 4   GLU n 
1 5   SER n 
1 6   LYS n 
1 7   LYS n 
1 8   ARG n 
1 9   GLN n 
1 10  TRP n 
1 11  ALA n 
1 12  LEU n 
1 13  GLU n 
1 14  ASP n 
1 15  PHE n 
1 16  GLU n 
1 17  ILE n 
1 18  GLY n 
1 19  ARG n 
1 20  PRO n 
1 21  LEU n 
1 22  GLY n 
1 23  LYS n 
1 24  GLY n 
1 25  LYS n 
1 26  PHE n 
1 27  GLY n 
1 28  ASN n 
1 29  VAL n 
1 30  TYR n 
1 31  LEU n 
1 32  ALA n 
1 33  ARG n 
1 34  GLU n 
1 35  LYS n 
1 36  GLN n 
1 37  SER n 
1 38  LYS n 
1 39  PHE n 
1 40  ILE n 
1 41  LEU n 
1 42  ALA n 
1 43  LEU n 
1 44  LYS n 
1 45  VAL n 
1 46  LEU n 
1 47  PHE n 
1 48  LYS n 
1 49  ALA n 
1 50  GLN n 
1 51  LEU n 
1 52  GLU n 
1 53  LYS n 
1 54  ALA n 
1 55  GLY n 
1 56  VAL n 
1 57  GLU n 
1 58  HIS n 
1 59  GLN n 
1 60  LEU n 
1 61  ARG n 
1 62  ARG n 
1 63  GLU n 
1 64  VAL n 
1 65  GLU n 
1 66  ILE n 
1 67  GLN n 
1 68  SER n 
1 69  HIS n 
1 70  LEU n 
1 71  ARG n 
1 72  HIS n 
1 73  PRO n 
1 74  ASN n 
1 75  ILE n 
1 76  LEU n 
1 77  ARG n 
1 78  LEU n 
1 79  TYR n 
1 80  GLY n 
1 81  TYR n 
1 82  PHE n 
1 83  HIS n 
1 84  ASP n 
1 85  ALA n 
1 86  THR n 
1 87  ARG n 
1 88  VAL n 
1 89  TYR n 
1 90  LEU n 
1 91  ILE n 
1 92  LEU n 
1 93  GLU n 
1 94  TYR n 
1 95  ALA n 
1 96  PRO n 
1 97  LEU n 
1 98  GLY n 
1 99  THR n 
1 100 VAL n 
1 101 TYR n 
1 102 ARG n 
1 103 GLU n 
1 104 LEU n 
1 105 GLN n 
1 106 LYS n 
1 107 LEU n 
1 108 SER n 
1 109 LYS n 
1 110 PHE n 
1 111 ASP n 
1 112 GLU n 
1 113 GLN n 
1 114 ARG n 
1 115 THR n 
1 116 ALA n 
1 117 THR n 
1 118 TYR n 
1 119 ILE n 
1 120 THR n 
1 121 GLU n 
1 122 LEU n 
1 123 ALA n 
1 124 ASN n 
1 125 ALA n 
1 126 LEU n 
1 127 SER n 
1 128 TYR n 
1 129 CYS n 
1 130 HIS n 
1 131 SER n 
1 132 LYS n 
1 133 ARG n 
1 134 VAL n 
1 135 ILE n 
1 136 HIS n 
1 137 ARG n 
1 138 ASP n 
1 139 ILE n 
1 140 LYS n 
1 141 PRO n 
1 142 GLU n 
1 143 ASN n 
1 144 LEU n 
1 145 LEU n 
1 146 LEU n 
1 147 GLY n 
1 148 SER n 
1 149 ALA n 
1 150 GLY n 
1 151 GLU n 
1 152 LEU n 
1 153 LYS n 
1 154 ILE n 
1 155 ALA n 
1 156 ASP n 
1 157 PHE n 
1 158 GLY n 
1 159 TRP n 
1 160 SER n 
1 161 VAL n 
1 162 HIS n 
1 163 ALA n 
1 164 PRO n 
1 165 SER n 
1 166 SER n 
1 167 ARG n 
1 168 ARG n 
1 169 THR n 
1 170 TPO n 
1 171 LEU n 
1 172 ALA n 
1 173 GLY n 
1 174 THR n 
1 175 LEU n 
1 176 ASP n 
1 177 TYR n 
1 178 LEU n 
1 179 PRO n 
1 180 PRO n 
1 181 GLU n 
1 182 MET n 
1 183 ILE n 
1 184 GLU n 
1 185 GLY n 
1 186 ARG n 
1 187 MET n 
1 188 HIS n 
1 189 ASP n 
1 190 GLU n 
1 191 LYS n 
1 192 VAL n 
1 193 ASP n 
1 194 LEU n 
1 195 TRP n 
1 196 SER n 
1 197 LEU n 
1 198 GLY n 
1 199 VAL n 
1 200 LEU n 
1 201 CYS n 
1 202 TYR n 
1 203 GLU n 
1 204 PHE n 
1 205 LEU n 
1 206 VAL n 
1 207 GLY n 
1 208 LYS n 
1 209 PRO n 
1 210 PRO n 
1 211 PHE n 
1 212 GLU n 
1 213 ALA n 
1 214 ASN n 
1 215 THR n 
1 216 TYR n 
1 217 GLN n 
1 218 GLU n 
1 219 THR n 
1 220 TYR n 
1 221 LYS n 
1 222 ARG n 
1 223 ILE n 
1 224 SER n 
1 225 ARG n 
1 226 VAL n 
1 227 GLU n 
1 228 PHE n 
1 229 THR n 
1 230 PHE n 
1 231 PRO n 
1 232 ASP n 
1 233 PHE n 
1 234 VAL n 
1 235 THR n 
1 236 GLU n 
1 237 GLY n 
1 238 ALA n 
1 239 ARG n 
1 240 ASP n 
1 241 LEU n 
1 242 ILE n 
1 243 SER n 
1 244 ARG n 
1 245 LEU n 
1 246 LEU n 
1 247 LYS n 
1 248 HIS n 
1 249 ASN n 
1 250 PRO n 
1 251 SER n 
1 252 GLN n 
1 253 ARG n 
1 254 PRO n 
1 255 MET n 
1 256 LEU n 
1 257 ARG n 
1 258 GLU n 
1 259 VAL n 
1 260 LEU n 
1 261 GLU n 
1 262 HIS n 
1 263 PRO n 
1 264 TRP n 
1 265 ILE n 
1 266 THR n 
1 267 ALA n 
1 268 ASN n 
1 269 SER n 
1 270 SER n 
1 271 LYS n 
1 272 PRO n 
1 273 SER n 
1 274 ASN n 
1 275 SER n 
1 276 GLN n 
1 277 ASN n 
1 278 LYS n 
1 279 GLU n 
1 280 SER n 
1 281 ALA n 
1 282 SER n 
1 283 LYS n 
1 284 GLN n 
1 285 SER n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   285 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'AURKA, AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              -RIL 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                                                                               ? 
'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                                                                              ? 
'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                                                                            ? 
'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                                                                       ? 
'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE                                                                                              ? 
'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE                                                                                             ? 
'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                                                                       ? 
'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                                                                               ? 
'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                                                                                             ? 
'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                                                                                 ? 
'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                                                                            ? 
'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                                                                               ? 
'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                                                                                ? 
'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                                                                                            ? 
'C5 H11 N O2 S'  149.211 
OG0 non-polymer         . '7-cyclopentyl-N,N-dimethyl-2-[4-(methylcarbamoyl)anilino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide' ? 
'C22 H26 N6 O2'  406.481 
PHE 'L-peptide linking' y PHENYLALANINE                                                                                         ? 
'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                                                                                               ? 
'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                                                                                ? 
'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                                                                                             ? 
'C4 H9 N O3'     119.119 
TPO 'L-peptide linking' n PHOSPHOTHREONINE                                                                                      
PHOSPHONOTHREONINE 'C4 H10 N O6 P'  199.099 
TRP 'L-peptide linking' y TRYPTOPHAN                                                                                            ? 
'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                                                                              ? 
'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                                                                                                ? 
'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   119 ?   ?   ?   A . n 
A 1 2   ALA 2   120 ?   ?   ?   A . n 
A 1 3   MET 3   121 ?   ?   ?   A . n 
A 1 4   GLU 4   122 ?   ?   ?   A . n 
A 1 5   SER 5   123 ?   ?   ?   A . n 
A 1 6   LYS 6   124 ?   ?   ?   A . n 
A 1 7   LYS 7   125 ?   ?   ?   A . n 
A 1 8   ARG 8   126 ?   ?   ?   A . n 
A 1 9   GLN 9   127 127 GLN GLN A . n 
A 1 10  TRP 10  128 128 TRP TRP A . n 
A 1 11  ALA 11  129 129 ALA ALA A . n 
A 1 12  LEU 12  130 130 LEU LEU A . n 
A 1 13  GLU 13  131 131 GLU GLU A . n 
A 1 14  ASP 14  132 132 ASP ASP A . n 
A 1 15  PHE 15  133 133 PHE PHE A . n 
A 1 16  GLU 16  134 134 GLU GLU A . n 
A 1 17  ILE 17  135 135 ILE ILE A . n 
A 1 18  GLY 18  136 136 GLY GLY A . n 
A 1 19  ARG 19  137 137 ARG ARG A . n 
A 1 20  PRO 20  138 138 PRO PRO A . n 
A 1 21  LEU 21  139 139 LEU LEU A . n 
A 1 22  GLY 22  140 140 GLY GLY A . n 
A 1 23  LYS 23  141 141 LYS LYS A . n 
A 1 24  GLY 24  142 142 GLY GLY A . n 
A 1 25  LYS 25  143 143 LYS LYS A . n 
A 1 26  PHE 26  144 144 PHE PHE A . n 
A 1 27  GLY 27  145 145 GLY GLY A . n 
A 1 28  ASN 28  146 146 ASN ASN A . n 
A 1 29  VAL 29  147 147 VAL VAL A . n 
A 1 30  TYR 30  148 148 TYR TYR A . n 
A 1 31  LEU 31  149 149 LEU LEU A . n 
A 1 32  ALA 32  150 150 ALA ALA A . n 
A 1 33  ARG 33  151 151 ARG ARG A . n 
A 1 34  GLU 34  152 152 GLU GLU A . n 
A 1 35  LYS 35  153 153 LYS LYS A . n 
A 1 36  GLN 36  154 154 GLN GLN A . n 
A 1 37  SER 37  155 155 SER SER A . n 
A 1 38  LYS 38  156 156 LYS LYS A . n 
A 1 39  PHE 39  157 157 PHE PHE A . n 
A 1 40  ILE 40  158 158 ILE ILE A . n 
A 1 41  LEU 41  159 159 LEU LEU A . n 
A 1 42  ALA 42  160 160 ALA ALA A . n 
A 1 43  LEU 43  161 161 LEU LEU A . n 
A 1 44  LYS 44  162 162 LYS LYS A . n 
A 1 45  VAL 45  163 163 VAL VAL A . n 
A 1 46  LEU 46  164 164 LEU LEU A . n 
A 1 47  PHE 47  165 165 PHE PHE A . n 
A 1 48  LYS 48  166 166 LYS LYS A . n 
A 1 49  ALA 49  167 167 ALA ALA A . n 
A 1 50  GLN 50  168 168 GLN GLN A . n 
A 1 51  LEU 51  169 169 LEU LEU A . n 
A 1 52  GLU 52  170 170 GLU GLU A . n 
A 1 53  LYS 53  171 171 LYS LYS A . n 
A 1 54  ALA 54  172 172 ALA ALA A . n 
A 1 55  GLY 55  173 173 GLY GLY A . n 
A 1 56  VAL 56  174 174 VAL VAL A . n 
A 1 57  GLU 57  175 175 GLU GLU A . n 
A 1 58  HIS 58  176 176 HIS HIS A . n 
A 1 59  GLN 59  177 177 GLN GLN A . n 
A 1 60  LEU 60  178 178 LEU LEU A . n 
A 1 61  ARG 61  179 179 ARG ARG A . n 
A 1 62  ARG 62  180 180 ARG ARG A . n 
A 1 63  GLU 63  181 181 GLU GLU A . n 
A 1 64  VAL 64  182 182 VAL VAL A . n 
A 1 65  GLU 65  183 183 GLU GLU A . n 
A 1 66  ILE 66  184 184 ILE ILE A . n 
A 1 67  GLN 67  185 185 GLN GLN A . n 
A 1 68  SER 68  186 186 SER SER A . n 
A 1 69  HIS 69  187 187 HIS HIS A . n 
A 1 70  LEU 70  188 188 LEU LEU A . n 
A 1 71  ARG 71  189 189 ARG ARG A . n 
A 1 72  HIS 72  190 190 HIS HIS A . n 
A 1 73  PRO 73  191 191 PRO PRO A . n 
A 1 74  ASN 74  192 192 ASN ASN A . n 
A 1 75  ILE 75  193 193 ILE ILE A . n 
A 1 76  LEU 76  194 194 LEU LEU A . n 
A 1 77  ARG 77  195 195 ARG ARG A . n 
A 1 78  LEU 78  196 196 LEU LEU A . n 
A 1 79  TYR 79  197 197 TYR TYR A . n 
A 1 80  GLY 80  198 198 GLY GLY A . n 
A 1 81  TYR 81  199 199 TYR TYR A . n 
A 1 82  PHE 82  200 200 PHE PHE A . n 
A 1 83  HIS 83  201 201 HIS HIS A . n 
A 1 84  ASP 84  202 202 ASP ASP A . n 
A 1 85  ALA 85  203 203 ALA ALA A . n 
A 1 86  THR 86  204 204 THR THR A . n 
A 1 87  ARG 87  205 205 ARG ARG A . n 
A 1 88  VAL 88  206 206 VAL VAL A . n 
A 1 89  TYR 89  207 207 TYR TYR A . n 
A 1 90  LEU 90  208 208 LEU LEU A . n 
A 1 91  ILE 91  209 209 ILE ILE A . n 
A 1 92  LEU 92  210 210 LEU LEU A . n 
A 1 93  GLU 93  211 211 GLU GLU A . n 
A 1 94  TYR 94  212 212 TYR TYR A . n 
A 1 95  ALA 95  213 213 ALA ALA A . n 
A 1 96  PRO 96  214 214 PRO PRO A . n 
A 1 97  LEU 97  215 215 LEU LEU A . n 
A 1 98  GLY 98  216 216 GLY GLY A . n 
A 1 99  THR 99  217 217 THR THR A . n 
A 1 100 VAL 100 218 218 VAL VAL A . n 
A 1 101 TYR 101 219 219 TYR TYR A . n 
A 1 102 ARG 102 220 220 ARG ARG A . n 
A 1 103 GLU 103 221 221 GLU GLU A . n 
A 1 104 LEU 104 222 222 LEU LEU A . n 
A 1 105 GLN 105 223 223 GLN GLN A . n 
A 1 106 LYS 106 224 224 LYS LYS A . n 
A 1 107 LEU 107 225 225 LEU LEU A . n 
A 1 108 SER 108 226 226 SER SER A . n 
A 1 109 LYS 109 227 227 LYS LYS A . n 
A 1 110 PHE 110 228 228 PHE PHE A . n 
A 1 111 ASP 111 229 229 ASP ASP A . n 
A 1 112 GLU 112 230 230 GLU GLU A . n 
A 1 113 GLN 113 231 231 GLN GLN A . n 
A 1 114 ARG 114 232 232 ARG ARG A . n 
A 1 115 THR 115 233 233 THR THR A . n 
A 1 116 ALA 116 234 234 ALA ALA A . n 
A 1 117 THR 117 235 235 THR THR A . n 
A 1 118 TYR 118 236 236 TYR TYR A . n 
A 1 119 ILE 119 237 237 ILE ILE A . n 
A 1 120 THR 120 238 238 THR THR A . n 
A 1 121 GLU 121 239 239 GLU GLU A . n 
A 1 122 LEU 122 240 240 LEU LEU A . n 
A 1 123 ALA 123 241 241 ALA ALA A . n 
A 1 124 ASN 124 242 242 ASN ASN A . n 
A 1 125 ALA 125 243 243 ALA ALA A . n 
A 1 126 LEU 126 244 244 LEU LEU A . n 
A 1 127 SER 127 245 245 SER SER A . n 
A 1 128 TYR 128 246 246 TYR TYR A . n 
A 1 129 CYS 129 247 247 CYS CYS A . n 
A 1 130 HIS 130 248 248 HIS HIS A . n 
A 1 131 SER 131 249 249 SER SER A . n 
A 1 132 LYS 132 250 250 LYS LYS A . n 
A 1 133 ARG 133 251 251 ARG ARG A . n 
A 1 134 VAL 134 252 252 VAL VAL A . n 
A 1 135 ILE 135 253 253 ILE ILE A . n 
A 1 136 HIS 136 254 254 HIS HIS A . n 
A 1 137 ARG 137 255 255 ARG ARG A . n 
A 1 138 ASP 138 256 256 ASP ASP A . n 
A 1 139 ILE 139 257 257 ILE ILE A . n 
A 1 140 LYS 140 258 258 LYS LYS A . n 
A 1 141 PRO 141 259 259 PRO PRO A . n 
A 1 142 GLU 142 260 260 GLU GLU A . n 
A 1 143 ASN 143 261 261 ASN ASN A . n 
A 1 144 LEU 144 262 262 LEU LEU A . n 
A 1 145 LEU 145 263 263 LEU LEU A . n 
A 1 146 LEU 146 264 264 LEU LEU A . n 
A 1 147 GLY 147 265 265 GLY GLY A . n 
A 1 148 SER 148 266 266 SER SER A . n 
A 1 149 ALA 149 267 267 ALA ALA A . n 
A 1 150 GLY 150 268 268 GLY GLY A . n 
A 1 151 GLU 151 269 269 GLU GLU A . n 
A 1 152 LEU 152 270 270 LEU LEU A . n 
A 1 153 LYS 153 271 271 LYS LYS A . n 
A 1 154 ILE 154 272 272 ILE ILE A . n 
A 1 155 ALA 155 273 273 ALA ALA A . n 
A 1 156 ASP 156 274 274 ASP ASP A . n 
A 1 157 PHE 157 275 275 PHE PHE A . n 
A 1 158 GLY 158 276 276 GLY GLY A . n 
A 1 159 TRP 159 277 277 TRP TRP A . n 
A 1 160 SER 160 278 278 SER SER A . n 
A 1 161 VAL 161 279 279 VAL VAL A . n 
A 1 162 HIS 162 280 280 HIS HIS A . n 
A 1 163 ALA 163 281 281 ALA ALA A . n 
A 1 164 PRO 164 282 282 PRO PRO A . n 
A 1 165 SER 165 283 283 SER SER A . n 
A 1 166 SER 166 284 284 SER SER A . n 
A 1 167 ARG 167 285 285 ARG ARG A . n 
A 1 168 ARG 168 286 286 ARG ARG A . n 
A 1 169 THR 169 287 287 THR THR A . n 
A 1 170 TPO 170 288 288 TPO TPO A . n 
A 1 171 LEU 171 289 289 LEU LEU A . n 
A 1 172 ALA 172 290 290 ALA ALA A . n 
A 1 173 GLY 173 291 291 GLY GLY A . n 
A 1 174 THR 174 292 292 THR THR A . n 
A 1 175 LEU 175 293 293 LEU LEU A . n 
A 1 176 ASP 176 294 294 ASP ASP A . n 
A 1 177 TYR 177 295 295 TYR TYR A . n 
A 1 178 LEU 178 296 296 LEU LEU A . n 
A 1 179 PRO 179 297 297 PRO PRO A . n 
A 1 180 PRO 180 298 298 PRO PRO A . n 
A 1 181 GLU 181 299 299 GLU GLU A . n 
A 1 182 MET 182 300 300 MET MET A . n 
A 1 183 ILE 183 301 301 ILE ILE A . n 
A 1 184 GLU 184 302 302 GLU GLU A . n 
A 1 185 GLY 185 303 303 GLY GLY A . n 
A 1 186 ARG 186 304 304 ARG ARG A . n 
A 1 187 MET 187 305 305 MET MET A . n 
A 1 188 HIS 188 306 306 HIS HIS A . n 
A 1 189 ASP 189 307 307 ASP ASP A . n 
A 1 190 GLU 190 308 308 GLU GLU A . n 
A 1 191 LYS 191 309 309 LYS LYS A . n 
A 1 192 VAL 192 310 310 VAL VAL A . n 
A 1 193 ASP 193 311 311 ASP ASP A . n 
A 1 194 LEU 194 312 312 LEU LEU A . n 
A 1 195 TRP 195 313 313 TRP TRP A . n 
A 1 196 SER 196 314 314 SER SER A . n 
A 1 197 LEU 197 315 315 LEU LEU A . n 
A 1 198 GLY 198 316 316 GLY GLY A . n 
A 1 199 VAL 199 317 317 VAL VAL A . n 
A 1 200 LEU 200 318 318 LEU LEU A . n 
A 1 201 CYS 201 319 319 CYS CYS A . n 
A 1 202 TYR 202 320 320 TYR TYR A . n 
A 1 203 GLU 203 321 321 GLU GLU A . n 
A 1 204 PHE 204 322 322 PHE PHE A . n 
A 1 205 LEU 205 323 323 LEU LEU A . n 
A 1 206 VAL 206 324 324 VAL VAL A . n 
A 1 207 GLY 207 325 325 GLY GLY A . n 
A 1 208 LYS 208 326 326 LYS LYS A . n 
A 1 209 PRO 209 327 327 PRO PRO A . n 
A 1 210 PRO 210 328 328 PRO PRO A . n 
A 1 211 PHE 211 329 329 PHE PHE A . n 
A 1 212 GLU 212 330 330 GLU GLU A . n 
A 1 213 ALA 213 331 331 ALA ALA A . n 
A 1 214 ASN 214 332 332 ASN ASN A . n 
A 1 215 THR 215 333 333 THR THR A . n 
A 1 216 TYR 216 334 334 TYR TYR A . n 
A 1 217 GLN 217 335 335 GLN GLN A . n 
A 1 218 GLU 218 336 336 GLU GLU A . n 
A 1 219 THR 219 337 337 THR THR A . n 
A 1 220 TYR 220 338 338 TYR TYR A . n 
A 1 221 LYS 221 339 339 LYS LYS A . n 
A 1 222 ARG 222 340 340 ARG ARG A . n 
A 1 223 ILE 223 341 341 ILE ILE A . n 
A 1 224 SER 224 342 342 SER SER A . n 
A 1 225 ARG 225 343 343 ARG ARG A . n 
A 1 226 VAL 226 344 344 VAL VAL A . n 
A 1 227 GLU 227 345 345 GLU GLU A . n 
A 1 228 PHE 228 346 346 PHE PHE A . n 
A 1 229 THR 229 347 347 THR THR A . n 
A 1 230 PHE 230 348 348 PHE PHE A . n 
A 1 231 PRO 231 349 349 PRO PRO A . n 
A 1 232 ASP 232 350 350 ASP ASP A . n 
A 1 233 PHE 233 351 351 PHE PHE A . n 
A 1 234 VAL 234 352 352 VAL VAL A . n 
A 1 235 THR 235 353 353 THR THR A . n 
A 1 236 GLU 236 354 354 GLU GLU A . n 
A 1 237 GLY 237 355 355 GLY GLY A . n 
A 1 238 ALA 238 356 356 ALA ALA A . n 
A 1 239 ARG 239 357 357 ARG ARG A . n 
A 1 240 ASP 240 358 358 ASP ASP A . n 
A 1 241 LEU 241 359 359 LEU LEU A . n 
A 1 242 ILE 242 360 360 ILE ILE A . n 
A 1 243 SER 243 361 361 SER SER A . n 
A 1 244 ARG 244 362 362 ARG ARG A . n 
A 1 245 LEU 245 363 363 LEU LEU A . n 
A 1 246 LEU 246 364 364 LEU LEU A . n 
A 1 247 LYS 247 365 365 LYS LYS A . n 
A 1 248 HIS 248 366 366 HIS HIS A . n 
A 1 249 ASN 249 367 367 ASN ASN A . n 
A 1 250 PRO 250 368 368 PRO PRO A . n 
A 1 251 SER 251 369 369 SER SER A . n 
A 1 252 GLN 252 370 370 GLN GLN A . n 
A 1 253 ARG 253 371 371 ARG ARG A . n 
A 1 254 PRO 254 372 372 PRO PRO A . n 
A 1 255 MET 255 373 373 MET MET A . n 
A 1 256 LEU 256 374 374 LEU LEU A . n 
A 1 257 ARG 257 375 375 ARG ARG A . n 
A 1 258 GLU 258 376 376 GLU GLU A . n 
A 1 259 VAL 259 377 377 VAL VAL A . n 
A 1 260 LEU 260 378 378 LEU LEU A . n 
A 1 261 GLU 261 379 379 GLU GLU A . n 
A 1 262 HIS 262 380 380 HIS HIS A . n 
A 1 263 PRO 263 381 381 PRO PRO A . n 
A 1 264 TRP 264 382 382 TRP TRP A . n 
A 1 265 ILE 265 383 383 ILE ILE A . n 
A 1 266 THR 266 384 384 THR THR A . n 
A 1 267 ALA 267 385 385 ALA ALA A . n 
A 1 268 ASN 268 386 386 ASN ASN A . n 
A 1 269 SER 269 387 387 SER SER A . n 
A 1 270 SER 270 388 388 SER SER A . n 
A 1 271 LYS 271 389 ?   ?   ?   A . n 
A 1 272 PRO 272 390 ?   ?   ?   A . n 
A 1 273 SER 273 391 ?   ?   ?   A . n 
A 1 274 ASN 274 392 ?   ?   ?   A . n 
A 1 275 SER 275 393 ?   ?   ?   A . n 
A 1 276 GLN 276 394 ?   ?   ?   A . n 
A 1 277 ASN 277 395 ?   ?   ?   A . n 
A 1 278 LYS 278 396 ?   ?   ?   A . n 
A 1 279 GLU 279 397 ?   ?   ?   A . n 
A 1 280 SER 280 398 ?   ?   ?   A . n 
A 1 281 ALA 281 399 ?   ?   ?   A . n 
A 1 282 SER 282 400 ?   ?   ?   A . n 
A 1 283 LYS 283 401 ?   ?   ?   A . n 
A 1 284 GLN 284 402 ?   ?   ?   A . n 
A 1 285 SER 285 403 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        OG0 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   OG0 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 OG0 1   501 401 OG0 LIG A . 
C 3 HOH 1   601 104 HOH HOH A . 
C 3 HOH 2   602 63  HOH HOH A . 
C 3 HOH 3   603 85  HOH HOH A . 
C 3 HOH 4   604 79  HOH HOH A . 
C 3 HOH 5   605 95  HOH HOH A . 
C 3 HOH 6   606 134 HOH HOH A . 
C 3 HOH 7   607 109 HOH HOH A . 
C 3 HOH 8   608 40  HOH HOH A . 
C 3 HOH 9   609 122 HOH HOH A . 
C 3 HOH 10  610 52  HOH HOH A . 
C 3 HOH 11  611 136 HOH HOH A . 
C 3 HOH 12  612 98  HOH HOH A . 
C 3 HOH 13  613 72  HOH HOH A . 
C 3 HOH 14  614 126 HOH HOH A . 
C 3 HOH 15  615 96  HOH HOH A . 
C 3 HOH 16  616 28  HOH HOH A . 
C 3 HOH 17  617 91  HOH HOH A . 
C 3 HOH 18  618 33  HOH HOH A . 
C 3 HOH 19  619 16  HOH HOH A . 
C 3 HOH 20  620 51  HOH HOH A . 
C 3 HOH 21  621 56  HOH HOH A . 
C 3 HOH 22  622 9   HOH HOH A . 
C 3 HOH 23  623 6   HOH HOH A . 
C 3 HOH 24  624 64  HOH HOH A . 
C 3 HOH 25  625 115 HOH HOH A . 
C 3 HOH 26  626 90  HOH HOH A . 
C 3 HOH 27  627 87  HOH HOH A . 
C 3 HOH 28  628 25  HOH HOH A . 
C 3 HOH 29  629 5   HOH HOH A . 
C 3 HOH 30  630 88  HOH HOH A . 
C 3 HOH 31  631 75  HOH HOH A . 
C 3 HOH 32  632 50  HOH HOH A . 
C 3 HOH 33  633 14  HOH HOH A . 
C 3 HOH 34  634 116 HOH HOH A . 
C 3 HOH 35  635 48  HOH HOH A . 
C 3 HOH 36  636 30  HOH HOH A . 
C 3 HOH 37  637 20  HOH HOH A . 
C 3 HOH 38  638 59  HOH HOH A . 
C 3 HOH 39  639 55  HOH HOH A . 
C 3 HOH 40  640 81  HOH HOH A . 
C 3 HOH 41  641 112 HOH HOH A . 
C 3 HOH 42  642 11  HOH HOH A . 
C 3 HOH 43  643 120 HOH HOH A . 
C 3 HOH 44  644 66  HOH HOH A . 
C 3 HOH 45  645 13  HOH HOH A . 
C 3 HOH 46  646 21  HOH HOH A . 
C 3 HOH 47  647 45  HOH HOH A . 
C 3 HOH 48  648 89  HOH HOH A . 
C 3 HOH 49  649 49  HOH HOH A . 
C 3 HOH 50  650 76  HOH HOH A . 
C 3 HOH 51  651 12  HOH HOH A . 
C 3 HOH 52  652 34  HOH HOH A . 
C 3 HOH 53  653 8   HOH HOH A . 
C 3 HOH 54  654 67  HOH HOH A . 
C 3 HOH 55  655 78  HOH HOH A . 
C 3 HOH 56  656 42  HOH HOH A . 
C 3 HOH 57  657 10  HOH HOH A . 
C 3 HOH 58  658 1   HOH HOH A . 
C 3 HOH 59  659 24  HOH HOH A . 
C 3 HOH 60  660 39  HOH HOH A . 
C 3 HOH 61  661 123 HOH HOH A . 
C 3 HOH 62  662 60  HOH HOH A . 
C 3 HOH 63  663 92  HOH HOH A . 
C 3 HOH 64  664 27  HOH HOH A . 
C 3 HOH 65  665 23  HOH HOH A . 
C 3 HOH 66  666 117 HOH HOH A . 
C 3 HOH 67  667 7   HOH HOH A . 
C 3 HOH 68  668 3   HOH HOH A . 
C 3 HOH 69  669 94  HOH HOH A . 
C 3 HOH 70  670 32  HOH HOH A . 
C 3 HOH 71  671 61  HOH HOH A . 
C 3 HOH 72  672 140 HOH HOH A . 
C 3 HOH 73  673 17  HOH HOH A . 
C 3 HOH 74  674 106 HOH HOH A . 
C 3 HOH 75  675 46  HOH HOH A . 
C 3 HOH 76  676 68  HOH HOH A . 
C 3 HOH 77  677 44  HOH HOH A . 
C 3 HOH 78  678 26  HOH HOH A . 
C 3 HOH 79  679 38  HOH HOH A . 
C 3 HOH 80  680 69  HOH HOH A . 
C 3 HOH 81  681 103 HOH HOH A . 
C 3 HOH 82  682 36  HOH HOH A . 
C 3 HOH 83  683 22  HOH HOH A . 
C 3 HOH 84  684 43  HOH HOH A . 
C 3 HOH 85  685 110 HOH HOH A . 
C 3 HOH 86  686 19  HOH HOH A . 
C 3 HOH 87  687 74  HOH HOH A . 
C 3 HOH 88  688 4   HOH HOH A . 
C 3 HOH 89  689 2   HOH HOH A . 
C 3 HOH 90  690 31  HOH HOH A . 
C 3 HOH 91  691 41  HOH HOH A . 
C 3 HOH 92  692 71  HOH HOH A . 
C 3 HOH 93  693 139 HOH HOH A . 
C 3 HOH 94  694 18  HOH HOH A . 
C 3 HOH 95  695 58  HOH HOH A . 
C 3 HOH 96  696 35  HOH HOH A . 
C 3 HOH 97  697 111 HOH HOH A . 
C 3 HOH 98  698 57  HOH HOH A . 
C 3 HOH 99  699 15  HOH HOH A . 
C 3 HOH 100 700 100 HOH HOH A . 
C 3 HOH 101 701 47  HOH HOH A . 
C 3 HOH 102 702 80  HOH HOH A . 
C 3 HOH 103 703 99  HOH HOH A . 
C 3 HOH 104 704 138 HOH HOH A . 
C 3 HOH 105 705 97  HOH HOH A . 
C 3 HOH 106 706 82  HOH HOH A . 
C 3 HOH 107 707 37  HOH HOH A . 
C 3 HOH 108 708 135 HOH HOH A . 
C 3 HOH 109 709 119 HOH HOH A . 
C 3 HOH 110 710 127 HOH HOH A . 
C 3 HOH 111 711 114 HOH HOH A . 
C 3 HOH 112 712 54  HOH HOH A . 
C 3 HOH 113 713 53  HOH HOH A . 
C 3 HOH 114 714 86  HOH HOH A . 
C 3 HOH 115 715 125 HOH HOH A . 
C 3 HOH 116 716 133 HOH HOH A . 
C 3 HOH 117 717 107 HOH HOH A . 
C 3 HOH 118 718 29  HOH HOH A . 
C 3 HOH 119 719 129 HOH HOH A . 
C 3 HOH 120 720 113 HOH HOH A . 
C 3 HOH 121 721 132 HOH HOH A . 
C 3 HOH 122 722 65  HOH HOH A . 
C 3 HOH 123 723 93  HOH HOH A . 
C 3 HOH 124 724 137 HOH HOH A . 
C 3 HOH 125 725 102 HOH HOH A . 
C 3 HOH 126 726 84  HOH HOH A . 
C 3 HOH 127 727 105 HOH HOH A . 
C 3 HOH 128 728 77  HOH HOH A . 
C 3 HOH 129 729 73  HOH HOH A . 
C 3 HOH 130 730 124 HOH HOH A . 
C 3 HOH 131 731 130 HOH HOH A . 
C 3 HOH 132 732 142 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A GLN 154 ? CG  ? A GLN 36  CG  
2  1 Y 1 A GLN 154 ? CD  ? A GLN 36  CD  
3  1 Y 1 A GLN 154 ? OE1 ? A GLN 36  OE1 
4  1 Y 1 A GLN 154 ? NE2 ? A GLN 36  NE2 
5  1 Y 1 A ARG 179 ? CG  ? A ARG 61  CG  
6  1 Y 1 A ARG 179 ? CD  ? A ARG 61  CD  
7  1 Y 1 A ARG 179 ? NE  ? A ARG 61  NE  
8  1 Y 1 A ARG 179 ? CZ  ? A ARG 61  CZ  
9  1 Y 1 A ARG 179 ? NH1 ? A ARG 61  NH1 
10 1 Y 1 A ARG 179 ? NH2 ? A ARG 61  NH2 
11 1 Y 1 A ARG 180 ? CG  ? A ARG 62  CG  
12 1 Y 1 A ARG 180 ? CD  ? A ARG 62  CD  
13 1 Y 1 A ARG 180 ? NE  ? A ARG 62  NE  
14 1 Y 1 A ARG 180 ? CZ  ? A ARG 62  CZ  
15 1 Y 1 A ARG 180 ? NH1 ? A ARG 62  NH1 
16 1 Y 1 A ARG 180 ? NH2 ? A ARG 62  NH2 
17 1 Y 1 A GLU 183 ? CG  ? A GLU 65  CG  
18 1 Y 1 A GLU 183 ? CD  ? A GLU 65  CD  
19 1 Y 1 A GLU 183 ? OE1 ? A GLU 65  OE1 
20 1 Y 1 A GLU 183 ? OE2 ? A GLU 65  OE2 
21 1 Y 1 A ARG 189 ? CG  ? A ARG 71  CG  
22 1 Y 1 A ARG 189 ? CD  ? A ARG 71  CD  
23 1 Y 1 A ARG 189 ? NE  ? A ARG 71  NE  
24 1 Y 1 A ARG 189 ? CZ  ? A ARG 71  CZ  
25 1 Y 1 A ARG 189 ? NH1 ? A ARG 71  NH1 
26 1 Y 1 A ARG 189 ? NH2 ? A ARG 71  NH2 
27 1 Y 1 A LYS 326 ? CE  ? A LYS 208 CE  
28 1 Y 1 A LYS 326 ? NZ  ? A LYS 208 NZ  
29 1 Y 1 A GLN 335 ? CG  ? A GLN 217 CG  
30 1 Y 1 A GLN 335 ? CD  ? A GLN 217 CD  
31 1 Y 1 A GLN 335 ? OE1 ? A GLN 217 OE1 
32 1 Y 1 A GLN 335 ? NE2 ? A GLN 217 NE2 
33 1 Y 0 A GLN 335 ? CA  A A GLN 217 CA  
34 1 Y 0 A GLN 335 ? CB  A A GLN 217 CB  
35 1 Y 1 A GLU 336 ? CG  ? A GLU 218 CG  
36 1 Y 1 A GLU 336 ? CD  ? A GLU 218 CD  
37 1 Y 1 A GLU 336 ? OE1 ? A GLU 218 OE1 
38 1 Y 1 A GLU 336 ? OE2 ? A GLU 218 OE2 
39 1 Y 1 A LYS 339 ? CG  ? A LYS 221 CG  
40 1 Y 1 A LYS 339 ? CD  ? A LYS 221 CD  
41 1 Y 1 A LYS 339 ? CE  ? A LYS 221 CE  
42 1 Y 1 A LYS 339 ? NZ  ? A LYS 221 NZ  
43 1 Y 1 A GLU 354 ? CG  ? A GLU 236 CG  
44 1 Y 1 A GLU 354 ? CD  ? A GLU 236 CD  
45 1 Y 1 A GLU 354 ? OE1 ? A GLU 236 OE1 
46 1 Y 1 A GLU 354 ? OE2 ? A GLU 236 OE2 
47 1 Y 1 A GLU 379 ? CG  ? A GLU 261 CG  
48 1 Y 1 A GLU 379 ? CD  ? A GLU 261 CD  
49 1 Y 1 A GLU 379 ? OE1 ? A GLU 261 OE1 
50 1 Y 1 A GLU 379 ? OE2 ? A GLU 261 OE2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.19.1_4122 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           3 
? 'model building' ? ? ? ? ? ? ? ? ? ? ? Coot     ? ? ? 0.8.9.2     4 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? .           5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BZG 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     84.648 
_cell.length_a_esd                 ? 
_cell.length_b                     84.648 
_cell.length_b_esd                 ? 
_cell.length_c                     78.873 
_cell.length_c_esd                 ? 
_cell.volume                       489432.038 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BZG 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                154 
_symmetry.space_group_name_Hall            
;P 32 2"
;
_symmetry.space_group_name_H-M             'P 32 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BZG 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.48 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          50.45 
_exptl_crystal.description                  'Hexagonal Rod' 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              5.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;0.1 M Sodium Citrate
16% PEG 3000
15 mg/mL AurA
;
_exptl_crystal_grow.pdbx_pH_range   5.4-5.7 
_exptl_crystal_grow.temp            298 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2020-10-27 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.98 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'APS BEAMLINE 24-ID-E' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.98 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   24-ID-E 
_diffrn_source.pdbx_synchrotron_site       APS 
# 
_reflns.B_iso_Wilson_estimate                          37.15 
_reflns.entry_id                                       9BZG 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.80 
_reflns.d_resolution_low                               53.70 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     55763 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           98.82 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3.3 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          11.84 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.06059 
_reflns.pdbx_Rpim_I_all                                0.03227 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   1 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.05095 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.800 
_reflns_shell.d_res_low                                     1.8957 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             8325 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               0.894 
_reflns_shell.pdbx_Rpim_I_all                               0.476 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.540 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.9 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.754 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               40.22 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9BZG 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.80 
_refine.ls_d_res_low                             53.70 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     55761 
_refine.ls_number_reflns_R_free                  2837 
_refine.ls_number_reflns_R_work                  52924 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    95.15 
_refine.ls_percent_reflns_R_free                 5.09 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1880 
_refine.ls_R_factor_R_free                       0.2196 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1863 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.36 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 25.7717 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2419 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.80 
_refine_hist.d_res_low                        53.70 
_refine_hist.number_atoms_solvent             132 
_refine_hist.number_atoms_total               2265 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2103 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         30 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0078 ? 2193 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.9800 ? 2980 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0603 ? 323  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0081 ? 377  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 6.9873 ? 310  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.80 1.83  . . 152 2787 99.09 . . . . 0.3091 . . . . . . . . . . . 0.3007 
'X-RAY DIFFRACTION' 1.83 1.86  . . 144 2722 98.93 . . . . 0.2933 . . . . . . . . . . . 0.3083 
'X-RAY DIFFRACTION' 1.86 1.90  . . 150 2741 98.33 . . . . 0.2923 . . . . . . . . . . . 0.3346 
'X-RAY DIFFRACTION' 1.90 1.94  . . 146 2675 97.44 . . . . 0.2775 . . . . . . . . . . . 0.3321 
'X-RAY DIFFRACTION' 1.94 1.98  . . 150 2704 96.78 . . . . 0.2472 . . . . . . . . . . . 0.3161 
'X-RAY DIFFRACTION' 1.98 2.03  . . 142 2689 96.39 . . . . 0.2336 . . . . . . . . . . . 0.3368 
'X-RAY DIFFRACTION' 2.03 2.08  . . 140 2537 91.33 . . . . 0.2156 . . . . . . . . . . . 0.2556 
'X-RAY DIFFRACTION' 2.08 2.13  . . 137 2643 95.11 . . . . 0.2154 . . . . . . . . . . . 0.2377 
'X-RAY DIFFRACTION' 2.13 2.20  . . 139 2746 98.80 . . . . 0.1992 . . . . . . . . . . . 0.2024 
'X-RAY DIFFRACTION' 2.20 2.27  . . 140 2752 98.67 . . . . 0.1925 . . . . . . . . . . . 0.2043 
'X-RAY DIFFRACTION' 2.27 2.35  . . 152 2701 98.01 . . . . 0.2172 . . . . . . . . . . . 0.2473 
'X-RAY DIFFRACTION' 2.35 2.44  . . 149 2715 97.15 . . . . 0.2073 . . . . . . . . . . . 0.2095 
'X-RAY DIFFRACTION' 2.44 2.55  . . 153 2684 96.30 . . . . 0.1943 . . . . . . . . . . . 0.2392 
'X-RAY DIFFRACTION' 2.55 2.69  . . 134 2625 95.07 . . . . 0.2062 . . . . . . . . . . . 0.2305 
'X-RAY DIFFRACTION' 2.69 2.86  . . 129 2509 90.28 . . . . 0.2103 . . . . . . . . . . . 0.2060 
'X-RAY DIFFRACTION' 2.86 3.08  . . 132 2466 88.58 . . . . 0.2022 . . . . . . . . . . . 0.2471 
'X-RAY DIFFRACTION' 3.08 3.39  . . 140 2603 92.70 . . . . 0.1747 . . . . . . . . . . . 0.2676 
'X-RAY DIFFRACTION' 3.39 3.88  . . 137 2540 91.62 . . . . 0.1602 . . . . . . . . . . . 0.1805 
'X-RAY DIFFRACTION' 3.88 4.88  . . 138 2530 91.43 . . . . 0.1439 . . . . . . . . . . . 0.1791 
'X-RAY DIFFRACTION' 4.89 53.70 . . 133 2555 91.46 . . . . 0.1744 . . . . . . . . . . . 0.1997 
# 
_struct.entry_id                     9BZG 
_struct.title                        'Targeting N-Myc in Neuroblastoma with Selective Aurora Kinase A Degraders' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BZG 
_struct_keywords.text            'Aurora A Kinase, AurA Kinase, N-Myc degrader, AurA Inhibitor, SIGNALING PROTEIN' 
_struct_keywords.pdbx_keywords   'SIGNALING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    AURKA_HUMAN 
_struct_ref.pdbx_db_accession          O14965 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;ESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFH
DATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHA
PSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLIS
RLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
;
_struct_ref.pdbx_align_begin           122 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9BZG 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 4 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 285 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             O14965 
_struct_ref_seq.db_align_beg                  122 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  403 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       122 
_struct_ref_seq.pdbx_auth_seq_align_end       403 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9BZG GLY A 1   ? UNP O14965 ?   ?   'expression tag'      119 1 
1 9BZG ALA A 2   ? UNP O14965 ?   ?   'expression tag'      120 2 
1 9BZG MET A 3   ? UNP O14965 ?   ?   'expression tag'      121 3 
1 9BZG ALA A 172 ? UNP O14965 CYS 290 'engineered mutation' 290 4 
1 9BZG SER A 275 ? UNP O14965 CYS 393 'engineered mutation' 393 5 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ALA A 11  ? GLU A 13  ? ALA A 129 GLU A 131 5 ? 3  
HELX_P HELX_P2  AA2 LYS A 48  ? GLY A 55  ? LYS A 166 GLY A 173 1 ? 8  
HELX_P HELX_P3  AA3 VAL A 56  ? SER A 68  ? VAL A 174 SER A 186 1 ? 13 
HELX_P HELX_P4  AA4 THR A 99  ? SER A 108 ? THR A 217 SER A 226 1 ? 10 
HELX_P HELX_P5  AA5 ASP A 111 ? LYS A 132 ? ASP A 229 LYS A 250 1 ? 22 
HELX_P HELX_P6  AA6 LYS A 140 ? GLU A 142 ? LYS A 258 GLU A 260 5 ? 3  
HELX_P HELX_P7  AA7 THR A 169 ? TYR A 177 ? THR A 287 TYR A 295 1 ? 9  
HELX_P HELX_P8  AA8 PRO A 179 ? GLU A 184 ? PRO A 297 GLU A 302 1 ? 6  
HELX_P HELX_P9  AA9 LYS A 191 ? GLY A 207 ? LYS A 309 GLY A 325 1 ? 17 
HELX_P HELX_P10 AB1 THR A 215 ? ARG A 225 ? THR A 333 ARG A 343 1 ? 11 
HELX_P HELX_P11 AB2 THR A 235 ? LEU A 246 ? THR A 353 LEU A 364 1 ? 12 
HELX_P HELX_P12 AB3 ASN A 249 ? ARG A 253 ? ASN A 367 ARG A 371 5 ? 5  
HELX_P HELX_P13 AB4 MET A 255 ? GLU A 261 ? MET A 373 GLU A 379 1 ? 7  
HELX_P HELX_P14 AB5 HIS A 262 ? SER A 269 ? HIS A 380 SER A 387 1 ? 8  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1 covale both ? A THR 169 C ? ? ? 1_555 A TPO 170 N ? ? A THR 287 A TPO 288 1_555 ? ? ? ? ? ? ? 1.336 ? ? 
covale2 covale both ? A TPO 170 C ? ? ? 1_555 A LEU 171 N ? ? A TPO 288 A LEU 289 1_555 ? ? ? ? ? ? ? 1.333 ? ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      TPO 
_pdbx_modification_feature.label_asym_id                      A 
_pdbx_modification_feature.label_seq_id                       170 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     . 
_pdbx_modification_feature.modified_residue_label_asym_id     . 
_pdbx_modification_feature.modified_residue_label_seq_id      . 
_pdbx_modification_feature.modified_residue_label_alt_id      . 
_pdbx_modification_feature.auth_comp_id                       TPO 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        288 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      . 
_pdbx_modification_feature.modified_residue_auth_asym_id      . 
_pdbx_modification_feature.modified_residue_auth_seq_id       . 
_pdbx_modification_feature.modified_residue_PDB_ins_code      . 
_pdbx_modification_feature.modified_residue_symmetry          . 
_pdbx_modification_feature.comp_id_linking_atom               . 
_pdbx_modification_feature.modified_residue_id_linking_atom   . 
_pdbx_modification_feature.modified_residue_id                THR 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        TPO 
_pdbx_modification_feature.type                               Phosphorylation 
_pdbx_modification_feature.category                           'Named protein modification' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 15  ? LYS A 23  ? PHE A 133 LYS A 141 
AA1 2 GLY A 27  ? GLU A 34  ? GLY A 145 GLU A 152 
AA1 3 ILE A 40  ? PHE A 47  ? ILE A 158 PHE A 165 
AA1 4 ARG A 87  ? LEU A 92  ? ARG A 205 LEU A 210 
AA1 5 LEU A 78  ? HIS A 83  ? LEU A 196 HIS A 201 
AA2 1 LEU A 144 ? LEU A 146 ? LEU A 262 LEU A 264 
AA2 2 LEU A 152 ? ILE A 154 ? LEU A 270 ILE A 272 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N LEU A 21  ? N LEU A 139 O VAL A 29  ? O VAL A 147 
AA1 2 3 N ASN A 28  ? N ASN A 146 O VAL A 45  ? O VAL A 163 
AA1 3 4 N LEU A 46  ? N LEU A 164 O VAL A 88  ? O VAL A 206 
AA1 4 5 O TYR A 89  ? O TYR A 207 N PHE A 82  ? N PHE A 200 
AA2 1 2 N LEU A 145 ? N LEU A 263 O LYS A 153 ? O LYS A 271 
# 
_pdbx_entry_details.entry_id                   9BZG 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 202 ? ? -128.83 -159.38 
2 1 SER A 226 ? ? 72.72   -47.28  
3 1 TRP A 277 ? ? 79.38   165.56  
4 1 LEU A 364 ? ? -91.74  41.77   
# 
_pdbx_struct_mod_residue.id               1 
_pdbx_struct_mod_residue.label_asym_id    A 
_pdbx_struct_mod_residue.label_comp_id    TPO 
_pdbx_struct_mod_residue.label_seq_id     170 
_pdbx_struct_mod_residue.auth_asym_id     A 
_pdbx_struct_mod_residue.auth_comp_id     TPO 
_pdbx_struct_mod_residue.auth_seq_id      288 
_pdbx_struct_mod_residue.PDB_ins_code     ? 
_pdbx_struct_mod_residue.parent_comp_id   THR 
_pdbx_struct_mod_residue.details          'modified residue' 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z          
2 -y,x-y,z+2/3   
3 -x+y,-x,z+1/3  
4 x-y,-y,-z+1/3  
5 -x,-x+y,-z+2/3 
6 y,x,-z         
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 119 ? A GLY 1   
2  1 Y 1 A ALA 120 ? A ALA 2   
3  1 Y 1 A MET 121 ? A MET 3   
4  1 Y 1 A GLU 122 ? A GLU 4   
5  1 Y 1 A SER 123 ? A SER 5   
6  1 Y 1 A LYS 124 ? A LYS 6   
7  1 Y 1 A LYS 125 ? A LYS 7   
8  1 Y 1 A ARG 126 ? A ARG 8   
9  1 Y 1 A LYS 389 ? A LYS 271 
10 1 Y 1 A PRO 390 ? A PRO 272 
11 1 Y 1 A SER 391 ? A SER 273 
12 1 Y 1 A ASN 392 ? A ASN 274 
13 1 Y 1 A SER 393 ? A SER 275 
14 1 Y 1 A GLN 394 ? A GLN 276 
15 1 Y 1 A ASN 395 ? A ASN 277 
16 1 Y 1 A LYS 396 ? A LYS 278 
17 1 Y 1 A GLU 397 ? A GLU 279 
18 1 Y 1 A SER 398 ? A SER 280 
19 1 Y 1 A ALA 399 ? A ALA 281 
20 1 Y 1 A SER 400 ? A SER 282 
21 1 Y 1 A LYS 401 ? A LYS 283 
22 1 Y 1 A GLN 402 ? A GLN 284 
23 1 Y 1 A SER 403 ? A SER 285 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N     N N N 1   
ALA CA    C N S 2   
ALA C     C N N 3   
ALA O     O N N 4   
ALA CB    C N N 5   
ALA OXT   O N N 6   
ALA H     H N N 7   
ALA H2    H N N 8   
ALA HA    H N N 9   
ALA HB1   H N N 10  
ALA HB2   H N N 11  
ALA HB3   H N N 12  
ALA HXT   H N N 13  
ARG N     N N N 14  
ARG CA    C N S 15  
ARG C     C N N 16  
ARG O     O N N 17  
ARG CB    C N N 18  
ARG CG    C N N 19  
ARG CD    C N N 20  
ARG NE    N N N 21  
ARG CZ    C N N 22  
ARG NH1   N N N 23  
ARG NH2   N N N 24  
ARG OXT   O N N 25  
ARG H     H N N 26  
ARG H2    H N N 27  
ARG HA    H N N 28  
ARG HB2   H N N 29  
ARG HB3   H N N 30  
ARG HG2   H N N 31  
ARG HG3   H N N 32  
ARG HD2   H N N 33  
ARG HD3   H N N 34  
ARG HE    H N N 35  
ARG HH11  H N N 36  
ARG HH12  H N N 37  
ARG HH21  H N N 38  
ARG HH22  H N N 39  
ARG HXT   H N N 40  
ASN N     N N N 41  
ASN CA    C N S 42  
ASN C     C N N 43  
ASN O     O N N 44  
ASN CB    C N N 45  
ASN CG    C N N 46  
ASN OD1   O N N 47  
ASN ND2   N N N 48  
ASN OXT   O N N 49  
ASN H     H N N 50  
ASN H2    H N N 51  
ASN HA    H N N 52  
ASN HB2   H N N 53  
ASN HB3   H N N 54  
ASN HD21  H N N 55  
ASN HD22  H N N 56  
ASN HXT   H N N 57  
ASP N     N N N 58  
ASP CA    C N S 59  
ASP C     C N N 60  
ASP O     O N N 61  
ASP CB    C N N 62  
ASP CG    C N N 63  
ASP OD1   O N N 64  
ASP OD2   O N N 65  
ASP OXT   O N N 66  
ASP H     H N N 67  
ASP H2    H N N 68  
ASP HA    H N N 69  
ASP HB2   H N N 70  
ASP HB3   H N N 71  
ASP HD2   H N N 72  
ASP HXT   H N N 73  
CYS N     N N N 74  
CYS CA    C N R 75  
CYS C     C N N 76  
CYS O     O N N 77  
CYS CB    C N N 78  
CYS SG    S N N 79  
CYS OXT   O N N 80  
CYS H     H N N 81  
CYS H2    H N N 82  
CYS HA    H N N 83  
CYS HB2   H N N 84  
CYS HB3   H N N 85  
CYS HG    H N N 86  
CYS HXT   H N N 87  
GLN N     N N N 88  
GLN CA    C N S 89  
GLN C     C N N 90  
GLN O     O N N 91  
GLN CB    C N N 92  
GLN CG    C N N 93  
GLN CD    C N N 94  
GLN OE1   O N N 95  
GLN NE2   N N N 96  
GLN OXT   O N N 97  
GLN H     H N N 98  
GLN H2    H N N 99  
GLN HA    H N N 100 
GLN HB2   H N N 101 
GLN HB3   H N N 102 
GLN HG2   H N N 103 
GLN HG3   H N N 104 
GLN HE21  H N N 105 
GLN HE22  H N N 106 
GLN HXT   H N N 107 
GLU N     N N N 108 
GLU CA    C N S 109 
GLU C     C N N 110 
GLU O     O N N 111 
GLU CB    C N N 112 
GLU CG    C N N 113 
GLU CD    C N N 114 
GLU OE1   O N N 115 
GLU OE2   O N N 116 
GLU OXT   O N N 117 
GLU H     H N N 118 
GLU H2    H N N 119 
GLU HA    H N N 120 
GLU HB2   H N N 121 
GLU HB3   H N N 122 
GLU HG2   H N N 123 
GLU HG3   H N N 124 
GLU HE2   H N N 125 
GLU HXT   H N N 126 
GLY N     N N N 127 
GLY CA    C N N 128 
GLY C     C N N 129 
GLY O     O N N 130 
GLY OXT   O N N 131 
GLY H     H N N 132 
GLY H2    H N N 133 
GLY HA2   H N N 134 
GLY HA3   H N N 135 
GLY HXT   H N N 136 
HIS N     N N N 137 
HIS CA    C N S 138 
HIS C     C N N 139 
HIS O     O N N 140 
HIS CB    C N N 141 
HIS CG    C Y N 142 
HIS ND1   N Y N 143 
HIS CD2   C Y N 144 
HIS CE1   C Y N 145 
HIS NE2   N Y N 146 
HIS OXT   O N N 147 
HIS H     H N N 148 
HIS H2    H N N 149 
HIS HA    H N N 150 
HIS HB2   H N N 151 
HIS HB3   H N N 152 
HIS HD1   H N N 153 
HIS HD2   H N N 154 
HIS HE1   H N N 155 
HIS HE2   H N N 156 
HIS HXT   H N N 157 
HOH O     O N N 158 
HOH H1    H N N 159 
HOH H2    H N N 160 
ILE N     N N N 161 
ILE CA    C N S 162 
ILE C     C N N 163 
ILE O     O N N 164 
ILE CB    C N S 165 
ILE CG1   C N N 166 
ILE CG2   C N N 167 
ILE CD1   C N N 168 
ILE OXT   O N N 169 
ILE H     H N N 170 
ILE H2    H N N 171 
ILE HA    H N N 172 
ILE HB    H N N 173 
ILE HG12  H N N 174 
ILE HG13  H N N 175 
ILE HG21  H N N 176 
ILE HG22  H N N 177 
ILE HG23  H N N 178 
ILE HD11  H N N 179 
ILE HD12  H N N 180 
ILE HD13  H N N 181 
ILE HXT   H N N 182 
LEU N     N N N 183 
LEU CA    C N S 184 
LEU C     C N N 185 
LEU O     O N N 186 
LEU CB    C N N 187 
LEU CG    C N N 188 
LEU CD1   C N N 189 
LEU CD2   C N N 190 
LEU OXT   O N N 191 
LEU H     H N N 192 
LEU H2    H N N 193 
LEU HA    H N N 194 
LEU HB2   H N N 195 
LEU HB3   H N N 196 
LEU HG    H N N 197 
LEU HD11  H N N 198 
LEU HD12  H N N 199 
LEU HD13  H N N 200 
LEU HD21  H N N 201 
LEU HD22  H N N 202 
LEU HD23  H N N 203 
LEU HXT   H N N 204 
LYS N     N N N 205 
LYS CA    C N S 206 
LYS C     C N N 207 
LYS O     O N N 208 
LYS CB    C N N 209 
LYS CG    C N N 210 
LYS CD    C N N 211 
LYS CE    C N N 212 
LYS NZ    N N N 213 
LYS OXT   O N N 214 
LYS H     H N N 215 
LYS H2    H N N 216 
LYS HA    H N N 217 
LYS HB2   H N N 218 
LYS HB3   H N N 219 
LYS HG2   H N N 220 
LYS HG3   H N N 221 
LYS HD2   H N N 222 
LYS HD3   H N N 223 
LYS HE2   H N N 224 
LYS HE3   H N N 225 
LYS HZ1   H N N 226 
LYS HZ2   H N N 227 
LYS HZ3   H N N 228 
LYS HXT   H N N 229 
MET N     N N N 230 
MET CA    C N S 231 
MET C     C N N 232 
MET O     O N N 233 
MET CB    C N N 234 
MET CG    C N N 235 
MET SD    S N N 236 
MET CE    C N N 237 
MET OXT   O N N 238 
MET H     H N N 239 
MET H2    H N N 240 
MET HA    H N N 241 
MET HB2   H N N 242 
MET HB3   H N N 243 
MET HG2   H N N 244 
MET HG3   H N N 245 
MET HE1   H N N 246 
MET HE2   H N N 247 
MET HE3   H N N 248 
MET HXT   H N N 249 
OG0 N1    N N N 250 
OG0 N3    N Y N 251 
OG0 C5    C Y N 252 
OG0 C6    C N N 253 
OG0 C7    C Y N 254 
OG0 C8    C Y N 255 
OG0 C10   C Y N 256 
OG0 C13   C N N 257 
OG0 C15   C N N 258 
OG0 C17   C Y N 259 
OG0 C20   C N N 260 
OG0 C21   C Y N 261 
OG0 C1    C N N 262 
OG0 "C1'" C Y N 263 
OG0 C12   C N N 264 
OG0 C14   C N N 265 
OG0 C16   C N N 266 
OG0 C19   C N N 267 
OG0 C2    C N N 268 
OG0 "C2'" C Y N 269 
OG0 "C3'" C Y N 270 
OG0 "C4'" C Y N 271 
OG0 "C5'" C Y N 272 
OG0 C9    C Y N 273 
OG0 N2    N N N 274 
OG0 N5    N Y N 275 
OG0 N7    N Y N 276 
OG0 N9    N N N 277 
OG0 O6    O N N 278 
OG0 OP3   O N N 279 
OG0 H1    H N N 280 
OG0 H2    H N N 281 
OG0 H3    H N N 282 
OG0 H4    H N N 283 
OG0 H5    H N N 284 
OG0 H6    H N N 285 
OG0 H7    H N N 286 
OG0 H8    H N N 287 
OG0 H9    H N N 288 
OG0 H10   H N N 289 
OG0 H11   H N N 290 
OG0 H12   H N N 291 
OG0 H13   H N N 292 
OG0 H14   H N N 293 
OG0 H15   H N N 294 
OG0 H16   H N N 295 
OG0 H17   H N N 296 
OG0 H18   H N N 297 
OG0 H19   H N N 298 
OG0 H20   H N N 299 
OG0 H21   H N N 300 
OG0 H22   H N N 301 
OG0 H23   H N N 302 
OG0 H24   H N N 303 
OG0 H25   H N N 304 
OG0 H26   H N N 305 
PHE N     N N N 306 
PHE CA    C N S 307 
PHE C     C N N 308 
PHE O     O N N 309 
PHE CB    C N N 310 
PHE CG    C Y N 311 
PHE CD1   C Y N 312 
PHE CD2   C Y N 313 
PHE CE1   C Y N 314 
PHE CE2   C Y N 315 
PHE CZ    C Y N 316 
PHE OXT   O N N 317 
PHE H     H N N 318 
PHE H2    H N N 319 
PHE HA    H N N 320 
PHE HB2   H N N 321 
PHE HB3   H N N 322 
PHE HD1   H N N 323 
PHE HD2   H N N 324 
PHE HE1   H N N 325 
PHE HE2   H N N 326 
PHE HZ    H N N 327 
PHE HXT   H N N 328 
PRO N     N N N 329 
PRO CA    C N S 330 
PRO C     C N N 331 
PRO O     O N N 332 
PRO CB    C N N 333 
PRO CG    C N N 334 
PRO CD    C N N 335 
PRO OXT   O N N 336 
PRO H     H N N 337 
PRO HA    H N N 338 
PRO HB2   H N N 339 
PRO HB3   H N N 340 
PRO HG2   H N N 341 
PRO HG3   H N N 342 
PRO HD2   H N N 343 
PRO HD3   H N N 344 
PRO HXT   H N N 345 
SER N     N N N 346 
SER CA    C N S 347 
SER C     C N N 348 
SER O     O N N 349 
SER CB    C N N 350 
SER OG    O N N 351 
SER OXT   O N N 352 
SER H     H N N 353 
SER H2    H N N 354 
SER HA    H N N 355 
SER HB2   H N N 356 
SER HB3   H N N 357 
SER HG    H N N 358 
SER HXT   H N N 359 
THR N     N N N 360 
THR CA    C N S 361 
THR C     C N N 362 
THR O     O N N 363 
THR CB    C N R 364 
THR OG1   O N N 365 
THR CG2   C N N 366 
THR OXT   O N N 367 
THR H     H N N 368 
THR H2    H N N 369 
THR HA    H N N 370 
THR HB    H N N 371 
THR HG1   H N N 372 
THR HG21  H N N 373 
THR HG22  H N N 374 
THR HG23  H N N 375 
THR HXT   H N N 376 
TPO N     N N N 377 
TPO CA    C N S 378 
TPO CB    C N R 379 
TPO CG2   C N N 380 
TPO OG1   O N N 381 
TPO P     P N N 382 
TPO O1P   O N N 383 
TPO O2P   O N N 384 
TPO O3P   O N N 385 
TPO C     C N N 386 
TPO O     O N N 387 
TPO OXT   O N N 388 
TPO H     H N N 389 
TPO H2    H N N 390 
TPO HA    H N N 391 
TPO HB    H N N 392 
TPO HG21  H N N 393 
TPO HG22  H N N 394 
TPO HG23  H N N 395 
TPO HOP2  H N N 396 
TPO HOP3  H N N 397 
TPO HXT   H N N 398 
TRP N     N N N 399 
TRP CA    C N S 400 
TRP C     C N N 401 
TRP O     O N N 402 
TRP CB    C N N 403 
TRP CG    C Y N 404 
TRP CD1   C Y N 405 
TRP CD2   C Y N 406 
TRP NE1   N Y N 407 
TRP CE2   C Y N 408 
TRP CE3   C Y N 409 
TRP CZ2   C Y N 410 
TRP CZ3   C Y N 411 
TRP CH2   C Y N 412 
TRP OXT   O N N 413 
TRP H     H N N 414 
TRP H2    H N N 415 
TRP HA    H N N 416 
TRP HB2   H N N 417 
TRP HB3   H N N 418 
TRP HD1   H N N 419 
TRP HE1   H N N 420 
TRP HE3   H N N 421 
TRP HZ2   H N N 422 
TRP HZ3   H N N 423 
TRP HH2   H N N 424 
TRP HXT   H N N 425 
TYR N     N N N 426 
TYR CA    C N S 427 
TYR C     C N N 428 
TYR O     O N N 429 
TYR CB    C N N 430 
TYR CG    C Y N 431 
TYR CD1   C Y N 432 
TYR CD2   C Y N 433 
TYR CE1   C Y N 434 
TYR CE2   C Y N 435 
TYR CZ    C Y N 436 
TYR OH    O N N 437 
TYR OXT   O N N 438 
TYR H     H N N 439 
TYR H2    H N N 440 
TYR HA    H N N 441 
TYR HB2   H N N 442 
TYR HB3   H N N 443 
TYR HD1   H N N 444 
TYR HD2   H N N 445 
TYR HE1   H N N 446 
TYR HE2   H N N 447 
TYR HH    H N N 448 
TYR HXT   H N N 449 
VAL N     N N N 450 
VAL CA    C N S 451 
VAL C     C N N 452 
VAL O     O N N 453 
VAL CB    C N N 454 
VAL CG1   C N N 455 
VAL CG2   C N N 456 
VAL OXT   O N N 457 
VAL H     H N N 458 
VAL H2    H N N 459 
VAL HA    H N N 460 
VAL HB    H N N 461 
VAL HG11  H N N 462 
VAL HG12  H N N 463 
VAL HG13  H N N 464 
VAL HG21  H N N 465 
VAL HG22  H N N 466 
VAL HG23  H N N 467 
VAL HXT   H N N 468 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N     CA    sing N N 1   
ALA N     H     sing N N 2   
ALA N     H2    sing N N 3   
ALA CA    C     sing N N 4   
ALA CA    CB    sing N N 5   
ALA CA    HA    sing N N 6   
ALA C     O     doub N N 7   
ALA C     OXT   sing N N 8   
ALA CB    HB1   sing N N 9   
ALA CB    HB2   sing N N 10  
ALA CB    HB3   sing N N 11  
ALA OXT   HXT   sing N N 12  
ARG N     CA    sing N N 13  
ARG N     H     sing N N 14  
ARG N     H2    sing N N 15  
ARG CA    C     sing N N 16  
ARG CA    CB    sing N N 17  
ARG CA    HA    sing N N 18  
ARG C     O     doub N N 19  
ARG C     OXT   sing N N 20  
ARG CB    CG    sing N N 21  
ARG CB    HB2   sing N N 22  
ARG CB    HB3   sing N N 23  
ARG CG    CD    sing N N 24  
ARG CG    HG2   sing N N 25  
ARG CG    HG3   sing N N 26  
ARG CD    NE    sing N N 27  
ARG CD    HD2   sing N N 28  
ARG CD    HD3   sing N N 29  
ARG NE    CZ    sing N N 30  
ARG NE    HE    sing N N 31  
ARG CZ    NH1   sing N N 32  
ARG CZ    NH2   doub N N 33  
ARG NH1   HH11  sing N N 34  
ARG NH1   HH12  sing N N 35  
ARG NH2   HH21  sing N N 36  
ARG NH2   HH22  sing N N 37  
ARG OXT   HXT   sing N N 38  
ASN N     CA    sing N N 39  
ASN N     H     sing N N 40  
ASN N     H2    sing N N 41  
ASN CA    C     sing N N 42  
ASN CA    CB    sing N N 43  
ASN CA    HA    sing N N 44  
ASN C     O     doub N N 45  
ASN C     OXT   sing N N 46  
ASN CB    CG    sing N N 47  
ASN CB    HB2   sing N N 48  
ASN CB    HB3   sing N N 49  
ASN CG    OD1   doub N N 50  
ASN CG    ND2   sing N N 51  
ASN ND2   HD21  sing N N 52  
ASN ND2   HD22  sing N N 53  
ASN OXT   HXT   sing N N 54  
ASP N     CA    sing N N 55  
ASP N     H     sing N N 56  
ASP N     H2    sing N N 57  
ASP CA    C     sing N N 58  
ASP CA    CB    sing N N 59  
ASP CA    HA    sing N N 60  
ASP C     O     doub N N 61  
ASP C     OXT   sing N N 62  
ASP CB    CG    sing N N 63  
ASP CB    HB2   sing N N 64  
ASP CB    HB3   sing N N 65  
ASP CG    OD1   doub N N 66  
ASP CG    OD2   sing N N 67  
ASP OD2   HD2   sing N N 68  
ASP OXT   HXT   sing N N 69  
CYS N     CA    sing N N 70  
CYS N     H     sing N N 71  
CYS N     H2    sing N N 72  
CYS CA    C     sing N N 73  
CYS CA    CB    sing N N 74  
CYS CA    HA    sing N N 75  
CYS C     O     doub N N 76  
CYS C     OXT   sing N N 77  
CYS CB    SG    sing N N 78  
CYS CB    HB2   sing N N 79  
CYS CB    HB3   sing N N 80  
CYS SG    HG    sing N N 81  
CYS OXT   HXT   sing N N 82  
GLN N     CA    sing N N 83  
GLN N     H     sing N N 84  
GLN N     H2    sing N N 85  
GLN CA    C     sing N N 86  
GLN CA    CB    sing N N 87  
GLN CA    HA    sing N N 88  
GLN C     O     doub N N 89  
GLN C     OXT   sing N N 90  
GLN CB    CG    sing N N 91  
GLN CB    HB2   sing N N 92  
GLN CB    HB3   sing N N 93  
GLN CG    CD    sing N N 94  
GLN CG    HG2   sing N N 95  
GLN CG    HG3   sing N N 96  
GLN CD    OE1   doub N N 97  
GLN CD    NE2   sing N N 98  
GLN NE2   HE21  sing N N 99  
GLN NE2   HE22  sing N N 100 
GLN OXT   HXT   sing N N 101 
GLU N     CA    sing N N 102 
GLU N     H     sing N N 103 
GLU N     H2    sing N N 104 
GLU CA    C     sing N N 105 
GLU CA    CB    sing N N 106 
GLU CA    HA    sing N N 107 
GLU C     O     doub N N 108 
GLU C     OXT   sing N N 109 
GLU CB    CG    sing N N 110 
GLU CB    HB2   sing N N 111 
GLU CB    HB3   sing N N 112 
GLU CG    CD    sing N N 113 
GLU CG    HG2   sing N N 114 
GLU CG    HG3   sing N N 115 
GLU CD    OE1   doub N N 116 
GLU CD    OE2   sing N N 117 
GLU OE2   HE2   sing N N 118 
GLU OXT   HXT   sing N N 119 
GLY N     CA    sing N N 120 
GLY N     H     sing N N 121 
GLY N     H2    sing N N 122 
GLY CA    C     sing N N 123 
GLY CA    HA2   sing N N 124 
GLY CA    HA3   sing N N 125 
GLY C     O     doub N N 126 
GLY C     OXT   sing N N 127 
GLY OXT   HXT   sing N N 128 
HIS N     CA    sing N N 129 
HIS N     H     sing N N 130 
HIS N     H2    sing N N 131 
HIS CA    C     sing N N 132 
HIS CA    CB    sing N N 133 
HIS CA    HA    sing N N 134 
HIS C     O     doub N N 135 
HIS C     OXT   sing N N 136 
HIS CB    CG    sing N N 137 
HIS CB    HB2   sing N N 138 
HIS CB    HB3   sing N N 139 
HIS CG    ND1   sing Y N 140 
HIS CG    CD2   doub Y N 141 
HIS ND1   CE1   doub Y N 142 
HIS ND1   HD1   sing N N 143 
HIS CD2   NE2   sing Y N 144 
HIS CD2   HD2   sing N N 145 
HIS CE1   NE2   sing Y N 146 
HIS CE1   HE1   sing N N 147 
HIS NE2   HE2   sing N N 148 
HIS OXT   HXT   sing N N 149 
HOH O     H1    sing N N 150 
HOH O     H2    sing N N 151 
ILE N     CA    sing N N 152 
ILE N     H     sing N N 153 
ILE N     H2    sing N N 154 
ILE CA    C     sing N N 155 
ILE CA    CB    sing N N 156 
ILE CA    HA    sing N N 157 
ILE C     O     doub N N 158 
ILE C     OXT   sing N N 159 
ILE CB    CG1   sing N N 160 
ILE CB    CG2   sing N N 161 
ILE CB    HB    sing N N 162 
ILE CG1   CD1   sing N N 163 
ILE CG1   HG12  sing N N 164 
ILE CG1   HG13  sing N N 165 
ILE CG2   HG21  sing N N 166 
ILE CG2   HG22  sing N N 167 
ILE CG2   HG23  sing N N 168 
ILE CD1   HD11  sing N N 169 
ILE CD1   HD12  sing N N 170 
ILE CD1   HD13  sing N N 171 
ILE OXT   HXT   sing N N 172 
LEU N     CA    sing N N 173 
LEU N     H     sing N N 174 
LEU N     H2    sing N N 175 
LEU CA    C     sing N N 176 
LEU CA    CB    sing N N 177 
LEU CA    HA    sing N N 178 
LEU C     O     doub N N 179 
LEU C     OXT   sing N N 180 
LEU CB    CG    sing N N 181 
LEU CB    HB2   sing N N 182 
LEU CB    HB3   sing N N 183 
LEU CG    CD1   sing N N 184 
LEU CG    CD2   sing N N 185 
LEU CG    HG    sing N N 186 
LEU CD1   HD11  sing N N 187 
LEU CD1   HD12  sing N N 188 
LEU CD1   HD13  sing N N 189 
LEU CD2   HD21  sing N N 190 
LEU CD2   HD22  sing N N 191 
LEU CD2   HD23  sing N N 192 
LEU OXT   HXT   sing N N 193 
LYS N     CA    sing N N 194 
LYS N     H     sing N N 195 
LYS N     H2    sing N N 196 
LYS CA    C     sing N N 197 
LYS CA    CB    sing N N 198 
LYS CA    HA    sing N N 199 
LYS C     O     doub N N 200 
LYS C     OXT   sing N N 201 
LYS CB    CG    sing N N 202 
LYS CB    HB2   sing N N 203 
LYS CB    HB3   sing N N 204 
LYS CG    CD    sing N N 205 
LYS CG    HG2   sing N N 206 
LYS CG    HG3   sing N N 207 
LYS CD    CE    sing N N 208 
LYS CD    HD2   sing N N 209 
LYS CD    HD3   sing N N 210 
LYS CE    NZ    sing N N 211 
LYS CE    HE2   sing N N 212 
LYS CE    HE3   sing N N 213 
LYS NZ    HZ1   sing N N 214 
LYS NZ    HZ2   sing N N 215 
LYS NZ    HZ3   sing N N 216 
LYS OXT   HXT   sing N N 217 
MET N     CA    sing N N 218 
MET N     H     sing N N 219 
MET N     H2    sing N N 220 
MET CA    C     sing N N 221 
MET CA    CB    sing N N 222 
MET CA    HA    sing N N 223 
MET C     O     doub N N 224 
MET C     OXT   sing N N 225 
MET CB    CG    sing N N 226 
MET CB    HB2   sing N N 227 
MET CB    HB3   sing N N 228 
MET CG    SD    sing N N 229 
MET CG    HG2   sing N N 230 
MET CG    HG3   sing N N 231 
MET SD    CE    sing N N 232 
MET CE    HE1   sing N N 233 
MET CE    HE2   sing N N 234 
MET CE    HE3   sing N N 235 
MET OXT   HXT   sing N N 236 
OG0 C1    N2    sing N N 237 
OG0 OP3   C2    doub N N 238 
OG0 N2    C2    sing N N 239 
OG0 C2    "C4'" sing N N 240 
OG0 "C4'" "C5'" doub Y N 241 
OG0 "C4'" "C3'" sing Y N 242 
OG0 C14   C15   sing N N 243 
OG0 C14   C13   sing N N 244 
OG0 C15   C16   sing N N 245 
OG0 "C5'" C21   sing Y N 246 
OG0 "C3'" "C2'" doub Y N 247 
OG0 C13   C12   sing N N 248 
OG0 C21   "C1'" doub Y N 249 
OG0 C16   C12   sing N N 250 
OG0 C12   N7    sing N N 251 
OG0 "C2'" "C1'" sing Y N 252 
OG0 "C1'" N9    sing N N 253 
OG0 N7    C17   sing Y N 254 
OG0 N7    C5    sing Y N 255 
OG0 N5    C17   doub Y N 256 
OG0 N5    C7    sing Y N 257 
OG0 C20   N1    sing N N 258 
OG0 N9    C7    sing N N 259 
OG0 C19   N1    sing N N 260 
OG0 N1    C6    sing N N 261 
OG0 C17   C9    sing Y N 262 
OG0 C7    N3    doub Y N 263 
OG0 C6    O6    doub N N 264 
OG0 C6    C5    sing N N 265 
OG0 C5    C10   doub Y N 266 
OG0 C9    C10   sing Y N 267 
OG0 C9    C8    doub Y N 268 
OG0 N3    C8    sing Y N 269 
OG0 C8    H1    sing N N 270 
OG0 C10   H2    sing N N 271 
OG0 C13   H3    sing N N 272 
OG0 C13   H4    sing N N 273 
OG0 C15   H5    sing N N 274 
OG0 C15   H6    sing N N 275 
OG0 C20   H7    sing N N 276 
OG0 C20   H8    sing N N 277 
OG0 C20   H9    sing N N 278 
OG0 C21   H10   sing N N 279 
OG0 C1    H11   sing N N 280 
OG0 C1    H12   sing N N 281 
OG0 C1    H13   sing N N 282 
OG0 C12   H14   sing N N 283 
OG0 C14   H15   sing N N 284 
OG0 C14   H16   sing N N 285 
OG0 C16   H17   sing N N 286 
OG0 C16   H18   sing N N 287 
OG0 C19   H19   sing N N 288 
OG0 C19   H20   sing N N 289 
OG0 C19   H21   sing N N 290 
OG0 "C2'" H22   sing N N 291 
OG0 "C3'" H23   sing N N 292 
OG0 "C5'" H24   sing N N 293 
OG0 N2    H25   sing N N 294 
OG0 N9    H26   sing N N 295 
PHE N     CA    sing N N 296 
PHE N     H     sing N N 297 
PHE N     H2    sing N N 298 
PHE CA    C     sing N N 299 
PHE CA    CB    sing N N 300 
PHE CA    HA    sing N N 301 
PHE C     O     doub N N 302 
PHE C     OXT   sing N N 303 
PHE CB    CG    sing N N 304 
PHE CB    HB2   sing N N 305 
PHE CB    HB3   sing N N 306 
PHE CG    CD1   doub Y N 307 
PHE CG    CD2   sing Y N 308 
PHE CD1   CE1   sing Y N 309 
PHE CD1   HD1   sing N N 310 
PHE CD2   CE2   doub Y N 311 
PHE CD2   HD2   sing N N 312 
PHE CE1   CZ    doub Y N 313 
PHE CE1   HE1   sing N N 314 
PHE CE2   CZ    sing Y N 315 
PHE CE2   HE2   sing N N 316 
PHE CZ    HZ    sing N N 317 
PHE OXT   HXT   sing N N 318 
PRO N     CA    sing N N 319 
PRO N     CD    sing N N 320 
PRO N     H     sing N N 321 
PRO CA    C     sing N N 322 
PRO CA    CB    sing N N 323 
PRO CA    HA    sing N N 324 
PRO C     O     doub N N 325 
PRO C     OXT   sing N N 326 
PRO CB    CG    sing N N 327 
PRO CB    HB2   sing N N 328 
PRO CB    HB3   sing N N 329 
PRO CG    CD    sing N N 330 
PRO CG    HG2   sing N N 331 
PRO CG    HG3   sing N N 332 
PRO CD    HD2   sing N N 333 
PRO CD    HD3   sing N N 334 
PRO OXT   HXT   sing N N 335 
SER N     CA    sing N N 336 
SER N     H     sing N N 337 
SER N     H2    sing N N 338 
SER CA    C     sing N N 339 
SER CA    CB    sing N N 340 
SER CA    HA    sing N N 341 
SER C     O     doub N N 342 
SER C     OXT   sing N N 343 
SER CB    OG    sing N N 344 
SER CB    HB2   sing N N 345 
SER CB    HB3   sing N N 346 
SER OG    HG    sing N N 347 
SER OXT   HXT   sing N N 348 
THR N     CA    sing N N 349 
THR N     H     sing N N 350 
THR N     H2    sing N N 351 
THR CA    C     sing N N 352 
THR CA    CB    sing N N 353 
THR CA    HA    sing N N 354 
THR C     O     doub N N 355 
THR C     OXT   sing N N 356 
THR CB    OG1   sing N N 357 
THR CB    CG2   sing N N 358 
THR CB    HB    sing N N 359 
THR OG1   HG1   sing N N 360 
THR CG2   HG21  sing N N 361 
THR CG2   HG22  sing N N 362 
THR CG2   HG23  sing N N 363 
THR OXT   HXT   sing N N 364 
TPO N     CA    sing N N 365 
TPO N     H     sing N N 366 
TPO N     H2    sing N N 367 
TPO CA    CB    sing N N 368 
TPO CA    C     sing N N 369 
TPO CA    HA    sing N N 370 
TPO CB    CG2   sing N N 371 
TPO CB    OG1   sing N N 372 
TPO CB    HB    sing N N 373 
TPO CG2   HG21  sing N N 374 
TPO CG2   HG22  sing N N 375 
TPO CG2   HG23  sing N N 376 
TPO OG1   P     sing N N 377 
TPO P     O1P   doub N N 378 
TPO P     O2P   sing N N 379 
TPO P     O3P   sing N N 380 
TPO O2P   HOP2  sing N N 381 
TPO O3P   HOP3  sing N N 382 
TPO C     O     doub N N 383 
TPO C     OXT   sing N N 384 
TPO OXT   HXT   sing N N 385 
TRP N     CA    sing N N 386 
TRP N     H     sing N N 387 
TRP N     H2    sing N N 388 
TRP CA    C     sing N N 389 
TRP CA    CB    sing N N 390 
TRP CA    HA    sing N N 391 
TRP C     O     doub N N 392 
TRP C     OXT   sing N N 393 
TRP CB    CG    sing N N 394 
TRP CB    HB2   sing N N 395 
TRP CB    HB3   sing N N 396 
TRP CG    CD1   doub Y N 397 
TRP CG    CD2   sing Y N 398 
TRP CD1   NE1   sing Y N 399 
TRP CD1   HD1   sing N N 400 
TRP CD2   CE2   doub Y N 401 
TRP CD2   CE3   sing Y N 402 
TRP NE1   CE2   sing Y N 403 
TRP NE1   HE1   sing N N 404 
TRP CE2   CZ2   sing Y N 405 
TRP CE3   CZ3   doub Y N 406 
TRP CE3   HE3   sing N N 407 
TRP CZ2   CH2   doub Y N 408 
TRP CZ2   HZ2   sing N N 409 
TRP CZ3   CH2   sing Y N 410 
TRP CZ3   HZ3   sing N N 411 
TRP CH2   HH2   sing N N 412 
TRP OXT   HXT   sing N N 413 
TYR N     CA    sing N N 414 
TYR N     H     sing N N 415 
TYR N     H2    sing N N 416 
TYR CA    C     sing N N 417 
TYR CA    CB    sing N N 418 
TYR CA    HA    sing N N 419 
TYR C     O     doub N N 420 
TYR C     OXT   sing N N 421 
TYR CB    CG    sing N N 422 
TYR CB    HB2   sing N N 423 
TYR CB    HB3   sing N N 424 
TYR CG    CD1   doub Y N 425 
TYR CG    CD2   sing Y N 426 
TYR CD1   CE1   sing Y N 427 
TYR CD1   HD1   sing N N 428 
TYR CD2   CE2   doub Y N 429 
TYR CD2   HD2   sing N N 430 
TYR CE1   CZ    doub Y N 431 
TYR CE1   HE1   sing N N 432 
TYR CE2   CZ    sing Y N 433 
TYR CE2   HE2   sing N N 434 
TYR CZ    OH    sing N N 435 
TYR OH    HH    sing N N 436 
TYR OXT   HXT   sing N N 437 
VAL N     CA    sing N N 438 
VAL N     H     sing N N 439 
VAL N     H2    sing N N 440 
VAL CA    C     sing N N 441 
VAL CA    CB    sing N N 442 
VAL CA    HA    sing N N 443 
VAL C     O     doub N N 444 
VAL C     OXT   sing N N 445 
VAL CB    CG1   sing N N 446 
VAL CB    CG2   sing N N 447 
VAL CB    HB    sing N N 448 
VAL CG1   HG11  sing N N 449 
VAL CG1   HG12  sing N N 450 
VAL CG1   HG13  sing N N 451 
VAL CG2   HG21  sing N N 452 
VAL CG2   HG22  sing N N 453 
VAL CG2   HG23  sing N N 454 
VAL OXT   HXT   sing N N 455 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Cancer Institute (NIH/NCI)' 'United States' P01-CA234228     1 
'Department of Defense (DOD, United States)'                        'United States' W81XWH-21-1-0674 2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5one 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 32 2 1' 
_space_group.name_Hall        
;P 32 2"
;
_space_group.IT_number        154 
_space_group.crystal_system   trigonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    9BZG 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.011814 
_atom_sites.fract_transf_matrix[1][2]   0.006821 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.013641 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.012679 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C   ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N   ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O   ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O1- ? ? 5.12366 3.84317 ? ? 3.49406  27.47979 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
P   ? ? 9.51135 5.44231 ? ? 1.42069  35.72801 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S   ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N     . GLN A 1 9   ? -20.38758 3.76896   8.65679   1.000 67.48083 ?  127 GLN A N     1 
ATOM   2    C CA    . GLN A 1 9   ? -20.67775 2.34353   8.56763   1.000 62.47571 ?  127 GLN A CA    1 
ATOM   3    C C     . GLN A 1 9   ? -20.59290 1.84020   7.12104   1.000 58.31590 ?  127 GLN A C     1 
ATOM   4    O O     . GLN A 1 9   ? -19.63708 1.15730   6.74861   1.000 57.60943 ?  127 GLN A O     1 
ATOM   5    C CB    . GLN A 1 9   ? -22.06494 2.03924   9.13445   1.000 62.18268 ?  127 GLN A CB    1 
ATOM   6    C CG    . GLN A 1 9   ? -22.22034 2.31969   10.60510  1.000 70.23321 ?  127 GLN A CG    1 
ATOM   7    C CD    . GLN A 1 9   ? -23.61222 1.99039   11.09223  1.000 75.47138 ?  127 GLN A CD    1 
ATOM   8    O OE1   . GLN A 1 9   ? -24.47130 1.58354   10.31013  1.000 76.61763 ?  127 GLN A OE1   1 
ATOM   9    N NE2   . GLN A 1 9   ? -23.84863 2.17186   12.38584  1.000 76.50013 ?  127 GLN A NE2   1 
ATOM   10   N N     . TRP A 1 10  ? -21.58233 2.20587   6.30763   1.000 55.51848 ?  128 TRP A N     1 
ATOM   11   C CA    . TRP A 1 10  ? -21.75275 1.58615   4.99779   1.000 49.71458 ?  128 TRP A CA    1 
ATOM   12   C C     . TRP A 1 10  ? -20.66317 1.98503   4.01266   1.000 48.21706 ?  128 TRP A C     1 
ATOM   13   O O     . TRP A 1 10  ? -20.14356 3.10108   4.03716   1.000 47.02224 ?  128 TRP A O     1 
ATOM   14   C CB    . TRP A 1 10  ? -23.10111 1.95972   4.38827   1.000 50.70718 ?  128 TRP A CB    1 
ATOM   15   C CG    . TRP A 1 10  ? -24.26338 1.66143   5.23681   1.000 50.93698 ?  128 TRP A CG    1 
ATOM   16   C CD1   . TRP A 1 10  ? -24.97465 2.54142   6.00595   1.000 52.54970 ?  128 TRP A CD1   1 
ATOM   17   C CD2   . TRP A 1 10  ? -24.86525 0.38358   5.42472   1.000 54.00877 ?  128 TRP A CD2   1 
ATOM   18   N NE1   . TRP A 1 10  ? -25.99706 1.88233   6.65093   1.000 52.68437 ?  128 TRP A NE1   1 
ATOM   19   C CE2   . TRP A 1 10  ? -25.94351 0.55488   6.31612   1.000 52.67572 ?  128 TRP A CE2   1 
ATOM   20   C CE3   . TRP A 1 10  ? -24.59413 -0.89432  4.93091   1.000 54.02544 ?  128 TRP A CE3   1 
ATOM   21   C CZ2   . TRP A 1 10  ? -26.75222 -0.49926  6.71256   1.000 57.84177 ?  128 TRP A CZ2   1 
ATOM   22   C CZ3   . TRP A 1 10  ? -25.39949 -1.94133  5.32992   1.000 55.67487 ?  128 TRP A CZ3   1 
ATOM   23   C CH2   . TRP A 1 10  ? -26.46545 -1.73846  6.20791   1.000 58.23014 ?  128 TRP A CH2   1 
ATOM   24   N N     . ALA A 1 11  ? -20.35080 1.05538   3.10957   1.000 46.46219 ?  129 ALA A N     1 
ATOM   25   C CA    . ALA A 1 11  ? -19.51860 1.32357   1.94523   1.000 48.08688 ?  129 ALA A CA    1 
ATOM   26   C C     . ALA A 1 11  ? -20.08989 0.55558   0.76113   1.000 44.08099 ?  129 ALA A C     1 
ATOM   27   O O     . ALA A 1 11  ? -20.89742 -0.36475  0.92211   1.000 44.08581 ?  129 ALA A O     1 
ATOM   28   C CB    . ALA A 1 11  ? -18.05333 0.93184   2.17862   1.000 50.59878 ?  129 ALA A CB    1 
ATOM   29   N N     . LEU A 1 12  ? -19.64319 0.93147   -0.43592  1.000 41.97610 ?  130 LEU A N     1 
ATOM   30   C CA    . LEU A 1 12  ? -20.11073 0.25598   -1.64075  1.000 45.97819 ?  130 LEU A CA    1 
ATOM   31   C C     . LEU A 1 12  ? -19.80042 -1.23547  -1.60824  1.000 47.60423 ?  130 LEU A C     1 
ATOM   32   O O     . LEU A 1 12  ? -20.59360 -2.04762  -2.10676  1.000 42.68847 ?  130 LEU A O     1 
ATOM   33   C CB    . LEU A 1 12  ? -19.48958 0.91008   -2.87237  1.000 45.09614 ?  130 LEU A CB    1 
ATOM   34   C CG    . LEU A 1 12  ? -20.03077 0.42328   -4.20753  1.000 45.38129 ?  130 LEU A CG    1 
ATOM   35   C CD1   . LEU A 1 12  ? -21.55332 0.57861   -4.25912  1.000 42.54778 ?  130 LEU A CD1   1 
ATOM   36   C CD2   . LEU A 1 12  ? -19.37695 1.23295   -5.30368  1.000 46.48309 ?  130 LEU A CD2   1 
ATOM   37   N N     . GLU A 1 13  ? -18.67187 -1.61622  -1.00093  1.000 45.38940 ?  131 GLU A N     1 
ATOM   38   C CA    . GLU A 1 13  ? -18.29588 -3.01791  -0.88522  1.000 48.63003 ?  131 GLU A CA    1 
ATOM   39   C C     . GLU A 1 13  ? -19.31017 -3.84815  -0.10914  1.000 45.91062 ?  131 GLU A C     1 
ATOM   40   O O     . GLU A 1 13  ? -19.24361 -5.08101  -0.16922  1.000 46.57791 ?  131 GLU A O     1 
ATOM   41   C CB    . GLU A 1 13  ? -16.91244 -3.12607  -0.21941  1.000 51.68305 ?  131 GLU A CB    1 
ATOM   42   C CG    . GLU A 1 13  ? -16.96841 -3.05563  1.31042   1.000 55.01432 ?  131 GLU A CG    1 
ATOM   43   C CD    . GLU A 1 13  ? -15.59138 -3.05732  1.99360   1.000 66.22804 ?  131 GLU A CD    1 
ATOM   44   O OE1   . GLU A 1 13  ? -14.55070 -3.07554  1.29162   1.000 69.66647 ?  131 GLU A OE1   1 
ATOM   45   O OE2   . GLU A 1 13  ? -15.55656 -3.03446  3.24396   1.000 66.97862 -1 131 GLU A OE2   1 
ATOM   46   N N     . ASP A 1 14  ? -20.23920 -3.22670  0.61782   1.000 41.97911 ?  132 ASP A N     1 
ATOM   47   C CA    . ASP A 1 14  ? -21.22958 -4.00784  1.35173   1.000 42.29055 ?  132 ASP A CA    1 
ATOM   48   C C     . ASP A 1 14  ? -22.34678 -4.55600  0.47965   1.000 43.27286 ?  132 ASP A C     1 
ATOM   49   O O     . ASP A 1 14  ? -23.19169 -5.30247  0.99286   1.000 39.99650 ?  132 ASP A O     1 
ATOM   50   C CB    . ASP A 1 14  ? -21.87102 -3.17858  2.46494   1.000 43.06188 ?  132 ASP A CB    1 
ATOM   51   C CG    . ASP A 1 14  ? -20.86742 -2.71255  3.48895   1.000 51.37891 ?  132 ASP A CG    1 
ATOM   52   O OD1   . ASP A 1 14  ? -20.29065 -3.59595  4.15471   1.000 52.86796 ?  132 ASP A OD1   1 
ATOM   53   O OD2   . ASP A 1 14  ? -20.68796 -1.48418  3.65270   1.000 51.30778 -1 132 ASP A OD2   1 
ATOM   54   N N     . PHE A 1 15  ? -22.38567 -4.20546  -0.80224  1.000 40.82626 ?  133 PHE A N     1 
ATOM   55   C CA    . PHE A 1 15  ? -23.54904 -4.48160  -1.63765  1.000 38.53380 ?  133 PHE A CA    1 
ATOM   56   C C     . PHE A 1 15  ? -23.15659 -5.19498  -2.92090  1.000 38.61561 ?  133 PHE A C     1 
ATOM   57   O O     . PHE A 1 15  ? -22.14396 -4.86366  -3.53887  1.000 39.74259 ?  133 PHE A O     1 
ATOM   58   C CB    . PHE A 1 15  ? -24.25571 -3.17156  -2.01683  1.000 38.60193 ?  133 PHE A CB    1 
ATOM   59   C CG    . PHE A 1 15  ? -24.67828 -2.35105  -0.83296  1.000 39.78716 ?  133 PHE A CG    1 
ATOM   60   C CD1   . PHE A 1 15  ? -25.83379 -2.65041  -0.14212  1.000 38.08105 ?  133 PHE A CD1   1 
ATOM   61   C CD2   . PHE A 1 15  ? -23.88480 -1.30232  -0.39061  1.000 41.59413 ?  133 PHE A CD2   1 
ATOM   62   C CE1   . PHE A 1 15  ? -26.21030 -1.89530  0.96462   1.000 43.16476 ?  133 PHE A CE1   1 
ATOM   63   C CE2   . PHE A 1 15  ? -24.25992 -0.54081  0.70228   1.000 40.11195 ?  133 PHE A CE2   1 
ATOM   64   C CZ    . PHE A 1 15  ? -25.41121 -0.84006  1.38069   1.000 38.93393 ?  133 PHE A CZ    1 
ATOM   65   N N     . GLU A 1 16  ? -23.99479 -6.14479  -3.33980  1.000 36.65580 ?  134 GLU A N     1 
ATOM   66   C CA    . GLU A 1 16  ? -24.03177 -6.57949  -4.72998  1.000 38.73227 ?  134 GLU A CA    1 
ATOM   67   C C     . GLU A 1 16  ? -24.94021 -5.65080  -5.53057  1.000 35.58959 ?  134 GLU A C     1 
ATOM   68   O O     . GLU A 1 16  ? -25.97618 -5.19619  -5.03017  1.000 37.67554 ?  134 GLU A O     1 
ATOM   69   C CB    . GLU A 1 16  ? -24.53487 -8.01961  -4.85489  1.000 35.35586 ?  134 GLU A CB    1 
ATOM   70   C CG    . GLU A 1 16  ? -23.50523 -9.11978  -4.56094  1.000 42.92790 ?  134 GLU A CG    1 
ATOM   71   C CD    . GLU A 1 16  ? -24.10358 -10.52969 -4.68162  1.000 44.67535 ?  134 GLU A CD    1 
ATOM   72   O OE1   . GLU A 1 16  ? -23.54392 -11.47735 -4.07816  1.000 43.61795 ?  134 GLU A OE1   1 
ATOM   73   O OE2   . GLU A 1 16  ? -25.15409 -10.68529 -5.35235  1.000 39.98593 -1 134 GLU A OE2   1 
ATOM   74   N N     . ILE A 1 17  ? -24.55046 -5.37739  -6.77414  1.000 34.28358 ?  135 ILE A N     1 
ATOM   75   C CA    . ILE A 1 17  ? -25.27650 -4.47492  -7.66111  1.000 33.89022 ?  135 ILE A CA    1 
ATOM   76   C C     . ILE A 1 17  ? -25.87965 -5.27313  -8.80467  1.000 36.65255 ?  135 ILE A C     1 
ATOM   77   O O     . ILE A 1 17  ? -25.20167 -6.10994  -9.41574  1.000 37.39950 ?  135 ILE A O     1 
ATOM   78   C CB    . ILE A 1 17  ? -24.36099 -3.37542  -8.23252  1.000 36.38539 ?  135 ILE A CB    1 
ATOM   79   C CG1   . ILE A 1 17  ? -23.57625 -2.69887  -7.11206  1.000 37.60721 ?  135 ILE A CG1   1 
ATOM   80   C CG2   . ILE A 1 17  ? -25.20070 -2.35318  -9.01240  1.000 36.74521 ?  135 ILE A CG2   1 
ATOM   81   C CD1   . ILE A 1 17  ? -24.45673 -2.06514  -6.07068  1.000 38.21306 ?  135 ILE A CD1   1 
ATOM   82   N N     . GLY A 1 18  ? -27.14014 -4.98127  -9.12037  1.000 36.17963 ?  136 GLY A N     1 
ATOM   83   C CA    . GLY A 1 18  ? -27.84090 -5.60172  -10.23499 1.000 33.64016 ?  136 GLY A CA    1 
ATOM   84   C C     . GLY A 1 18  ? -28.07831 -4.57412  -11.32560 1.000 35.21574 ?  136 GLY A C     1 
ATOM   85   O O     . GLY A 1 18  ? -27.23638 -3.69472  -11.52618 1.000 36.60294 ?  136 GLY A O     1 
ATOM   86   N N     . ARG A 1 19  ? -29.20938 -4.64707  -12.02177 1.000 36.57674 ?  137 ARG A N     1 
ATOM   87   C CA    . ARG A 1 19  ? -29.44923 -3.74092  -13.14117 1.000 39.69338 ?  137 ARG A CA    1 
ATOM   88   C C     . ARG A 1 19  ? -29.89495 -2.37139  -12.64431 1.000 36.30042 ?  137 ARG A C     1 
ATOM   89   O O     . ARG A 1 19  ? -30.43779 -2.24439  -11.54235 1.000 35.70200 ?  137 ARG A O     1 
ATOM   90   C CB    . ARG A 1 19  ? -30.53752 -4.28959  -14.06570 1.000 41.73657 ?  137 ARG A CB    1 
ATOM   91   C CG    . ARG A 1 19  ? -31.95256 -4.24297  -13.47670 1.000 42.63453 ?  137 ARG A CG    1 
ATOM   92   C CD    . ARG A 1 19  ? -33.02054 -4.27221  -14.58558 1.000 48.59868 ?  137 ARG A CD    1 
ATOM   93   N NE    . ARG A 1 19  ? -34.38088 -4.20124  -14.06232 1.000 45.75539 ?  137 ARG A NE    1 
ATOM   94   C CZ    . ARG A 1 19  ? -34.92324 -5.10349  -13.25407 1.000 44.82474 ?  137 ARG A CZ    1 
ATOM   95   N NH1   . ARG A 1 19  ? -34.26624 -6.19315  -12.89147 1.000 48.99471 ?  137 ARG A NH1   1 
ATOM   96   N NH2   . ARG A 1 19  ? -36.14511 -4.89412  -12.78145 1.000 48.15890 ?  137 ARG A NH2   1 
ATOM   97   N N     . PRO A 1 20  ? -29.71660 -1.33142  -13.45525 1.000 35.57556 ?  138 PRO A N     1 
ATOM   98   C CA    . PRO A 1 20  ? -30.33786 -0.04247  -13.12770 1.000 36.01427 ?  138 PRO A CA    1 
ATOM   99   C C     . PRO A 1 20  ? -31.85035 -0.17055  -13.25272 1.000 39.46075 ?  138 PRO A C     1 
ATOM   100  O O     . PRO A 1 20  ? -32.35932 -0.71318  -14.23322 1.000 37.47490 ?  138 PRO A O     1 
ATOM   101  C CB    . PRO A 1 20  ? -29.75248 0.92073   -14.16588 1.000 36.42180 ?  138 PRO A CB    1 
ATOM   102  C CG    . PRO A 1 20  ? -29.34819 0.04989   -15.30392 1.000 40.55660 ?  138 PRO A CG    1 
ATOM   103  C CD    . PRO A 1 20  ? -28.94873 -1.27834  -14.71500 1.000 39.36461 ?  138 PRO A CD    1 
ATOM   104  N N     . LEU A 1 21  ? -32.56290 0.26628   -12.21734 1.000 33.47094 ?  139 LEU A N     1 
ATOM   105  C CA    . LEU A 1 21  ? -34.01563 0.33683   -12.30998 1.000 33.26807 ?  139 LEU A CA    1 
ATOM   106  C C     . LEU A 1 21  ? -34.45898 1.56284   -13.08716 1.000 33.15602 ?  139 LEU A C     1 
ATOM   107  O O     . LEU A 1 21  ? -35.51675 1.53637   -13.73468 1.000 30.93527 ?  139 LEU A O     1 
ATOM   108  C CB    . LEU A 1 21  ? -34.63603 0.36906   -10.91342 1.000 29.09981 ?  139 LEU A CB    1 
ATOM   109  C CG    . LEU A 1 21  ? -34.40940 -0.88400  -10.05300 1.000 34.68015 ?  139 LEU A CG    1 
ATOM   110  C CD1   . LEU A 1 21  ? -34.96340 -0.63091  -8.63183  1.000 32.74236 ?  139 LEU A CD1   1 
ATOM   111  C CD2   . LEU A 1 21  ? -35.04039 -2.13588  -10.68490 1.000 35.83461 ?  139 LEU A CD2   1 
ATOM   112  N N     . GLY A 1 22  ? -33.66646 2.62906   -13.04060 1.000 33.14487 ?  140 GLY A N     1 
ATOM   113  C CA    . GLY A 1 22  ? -33.99743 3.86563   -13.73762 1.000 34.15952 ?  140 GLY A CA    1 
ATOM   114  C C     . GLY A 1 22  ? -32.84230 4.84136   -13.66393 1.000 33.31237 ?  140 GLY A C     1 
ATOM   115  O O     . GLY A 1 22  ? -31.83896 4.59648   -12.99179 1.000 34.17398 ?  140 GLY A O     1 
ATOM   116  N N     . LYS A 1 23  ? -32.99822 5.96233   -14.37849 1.000 30.90130 ?  141 LYS A N     1 
ATOM   117  C CA    . LYS A 1 23  ? -31.97768 7.00282   -14.45427 1.000 35.07403 ?  141 LYS A CA    1 
ATOM   118  C C     . LYS A 1 23  ? -32.63455 8.37182   -14.34562 1.000 34.87396 ?  141 LYS A C     1 
ATOM   119  O O     . LYS A 1 23  ? -33.74845 8.58348   -14.83555 1.000 34.73331 ?  141 LYS A O     1 
ATOM   120  C CB    . LYS A 1 23  ? -31.17107 6.95019   -15.77279 1.000 37.37843 ?  141 LYS A CB    1 
ATOM   121  C CG    . LYS A 1 23  ? -30.50206 5.62631   -16.08057 1.000 42.60004 ?  141 LYS A CG    1 
ATOM   122  C CD    . LYS A 1 23  ? -29.95565 5.57294   -17.52412 1.000 46.03498 ?  141 LYS A CD    1 
ATOM   123  C CE    . LYS A 1 23  ? -30.91405 6.20511   -18.54028 1.000 42.47817 ?  141 LYS A CE    1 
ATOM   124  N NZ    . LYS A 1 23  ? -30.38998 6.04199   -19.95263 1.000 52.65029 ?  141 LYS A NZ    1 
ATOM   125  N N     . GLY A 1 24  ? -31.90597 9.32081   -13.74907 1.000 33.80769 ?  142 GLY A N     1 
ATOM   126  C CA    . GLY A 1 24  ? -32.37239 10.68816  -13.63591 1.000 34.87382 ?  142 GLY A CA    1 
ATOM   127  C C     . GLY A 1 24  ? -31.24346 11.67184  -13.90667 1.000 35.38196 ?  142 GLY A C     1 
ATOM   128  O O     . GLY A 1 24  ? -30.12954 11.28539  -14.25428 1.000 35.10130 ?  142 GLY A O     1 
ATOM   129  N N     . LYS A 1 25  ? -31.57082 12.95801  -13.75381 1.000 37.79971 ?  143 LYS A N     1 
ATOM   130  C CA    . LYS A 1 25  ? -30.59746 14.02874  -13.96232 1.000 40.81434 ?  143 LYS A CA    1 
ATOM   131  C C     . LYS A 1 25  ? -29.36002 13.84246  -13.09881 1.000 40.74667 ?  143 LYS A C     1 
ATOM   132  O O     . LYS A 1 25  ? -28.23155 14.08088  -13.54511 1.000 38.85009 ?  143 LYS A O     1 
ATOM   133  C CB    . LYS A 1 25  ? -31.24465 15.37483  -13.63532 1.000 42.32421 ?  143 LYS A CB    1 
ATOM   134  C CG    . LYS A 1 25  ? -30.33667 16.55342  -13.88427 1.000 47.08472 ?  143 LYS A CG    1 
ATOM   135  C CD    . LYS A 1 25  ? -30.99255 17.86339  -13.49963 1.000 48.86047 ?  143 LYS A CD    1 
ATOM   136  C CE    . LYS A 1 25  ? -30.16599 19.02386  -14.04206 1.000 54.20703 ?  143 LYS A CE    1 
ATOM   137  N NZ    . LYS A 1 25  ? -28.81474 19.10286  -13.43825 1.000 56.13282 ?  143 LYS A NZ    1 
ATOM   138  N N     . PHE A 1 26  ? -29.55063 13.42524  -11.85442 1.000 39.19425 ?  144 PHE A N     1 
ATOM   139  C CA    . PHE A 1 26  ? -28.45600 13.40463  -10.90052 1.000 43.20662 ?  144 PHE A CA    1 
ATOM   140  C C     . PHE A 1 26  ? -27.78629 12.05102  -10.76388 1.000 43.49762 ?  144 PHE A C     1 
ATOM   141  O O     . PHE A 1 26  ? -26.66196 11.98685  -10.25517 1.000 45.93764 ?  144 PHE A O     1 
ATOM   142  C CB    . PHE A 1 26  ? -28.95355 13.89437  -9.53506  1.000 41.02477 ?  144 PHE A CB    1 
ATOM   143  C CG    . PHE A 1 26  ? -29.46366 15.28945  -9.56884  1.000 44.67651 ?  144 PHE A CG    1 
ATOM   144  C CD1   . PHE A 1 26  ? -28.57874 16.34710  -9.66848  1.000 48.96780 ?  144 PHE A CD1   1 
ATOM   145  C CD2   . PHE A 1 26  ? -30.81100 15.55301  -9.53773  1.000 46.61098 ?  144 PHE A CD2   1 
ATOM   146  C CE1   . PHE A 1 26  ? -29.03592 17.64789  -9.72163  1.000 49.64634 ?  144 PHE A CE1   1 
ATOM   147  C CE2   . PHE A 1 26  ? -31.27438 16.84479  -9.57755  1.000 47.51797 ?  144 PHE A CE2   1 
ATOM   148  C CZ    . PHE A 1 26  ? -30.38724 17.89643  -9.66741  1.000 49.67962 ?  144 PHE A CZ    1 
ATOM   149  N N     . GLY A 1 27  ? -28.41372 10.98040  -11.23595 1.000 42.94497 ?  145 GLY A N     1 
ATOM   150  C CA    . GLY A 1 27  ? -27.78256 9.67679   -11.17711 1.000 39.46095 ?  145 GLY A CA    1 
ATOM   151  C C     . GLY A 1 27  ? -28.79431 8.57433   -11.44355 1.000 40.81761 ?  145 GLY A C     1 
ATOM   152  O O     . GLY A 1 27  ? -29.85677 8.81733   -12.01313 1.000 36.52173 ?  145 GLY A O     1 
ATOM   153  N N     . ASN A 1 28  ? -28.44408 7.36706   -11.01303 1.000 37.67877 ?  146 ASN A N     1 
ATOM   154  C CA    . ASN A 1 28  ? -29.19429 6.15360   -11.30596 1.000 37.81380 ?  146 ASN A CA    1 
ATOM   155  C C     . ASN A 1 28  ? -29.60862 5.46396   -10.01755 1.000 35.48791 ?  146 ASN A C     1 
ATOM   156  O O     . ASN A 1 28  ? -29.01591 5.68568   -8.95727  1.000 33.09343 ?  146 ASN A O     1 
ATOM   157  C CB    . ASN A 1 28  ? -28.37551 5.17817   -12.14663 1.000 37.25027 ?  146 ASN A CB    1 
ATOM   158  C CG    . ASN A 1 28  ? -27.72770 5.84790   -13.33953 1.000 42.22863 ?  146 ASN A CG    1 
ATOM   159  O OD1   . ASN A 1 28  ? -28.27416 6.81092   -13.88907 1.000 46.27468 ?  146 ASN A OD1   1 
ATOM   160  N ND2   . ASN A 1 28  ? -26.56110 5.36522   -13.73227 1.000 45.65422 ?  146 ASN A ND2   1 
ATOM   161  N N     . VAL A 1 29  ? -30.63515 4.61912   -10.13661 1.000 32.31120 ?  147 VAL A N     1 
ATOM   162  C CA    . VAL A 1 29  ? -31.09501 3.75895   -9.05370  1.000 31.77595 ?  147 VAL A CA    1 
ATOM   163  C C     . VAL A 1 29  ? -30.90036 2.31937   -9.50630  1.000 31.92440 ?  147 VAL A C     1 
ATOM   164  O O     . VAL A 1 29  ? -31.38630 1.93617   -10.57977 1.000 31.48697 ?  147 VAL A O     1 
ATOM   165  C CB    . VAL A 1 29  ? -32.56502 4.03038   -8.69114  1.000 31.05469 ?  147 VAL A CB    1 
ATOM   166  C CG1   . VAL A 1 29  ? -33.04773 3.04664   -7.57437  1.000 31.80617 ?  147 VAL A CG1   1 
ATOM   167  C CG2   . VAL A 1 29  ? -32.75281 5.50269   -8.23545  1.000 30.03107 ?  147 VAL A CG2   1 
ATOM   168  N N     . TYR A 1 30  ? -30.16256 1.54249   -8.70997  1.000 31.15874 ?  148 TYR A N     1 
ATOM   169  C CA    . TYR A 1 30  ? -29.79877 0.16220   -9.02748  1.000 32.58986 ?  148 TYR A CA    1 
ATOM   170  C C     . TYR A 1 30  ? -30.55021 -0.79317  -8.12073  1.000 33.17866 ?  148 TYR A C     1 
ATOM   171  O O     . TYR A 1 30  ? -30.77960 -0.49696  -6.94449  1.000 29.82904 ?  148 TYR A O     1 
ATOM   172  C CB    . TYR A 1 30  ? -28.29448 -0.08560  -8.85647  1.000 33.48220 ?  148 TYR A CB    1 
ATOM   173  C CG    . TYR A 1 30  ? -27.48188 0.70943   -9.84250  1.000 35.56549 ?  148 TYR A CG    1 
ATOM   174  C CD1   . TYR A 1 30  ? -27.21737 0.22457   -11.12383 1.000 34.19471 ?  148 TYR A CD1   1 
ATOM   175  C CD2   . TYR A 1 30  ? -27.04250 1.97481   -9.52165  1.000 34.49023 ?  148 TYR A CD2   1 
ATOM   176  C CE1   . TYR A 1 30  ? -26.50692 0.99125   -12.03580 1.000 37.84399 ?  148 TYR A CE1   1 
ATOM   177  C CE2   . TYR A 1 30  ? -26.33626 2.74407   -10.42591 1.000 36.45028 ?  148 TYR A CE2   1 
ATOM   178  C CZ    . TYR A 1 30  ? -26.05845 2.25145   -11.66954 1.000 37.47380 ?  148 TYR A CZ    1 
ATOM   179  O OH    . TYR A 1 30  ? -25.34908 3.06013   -12.54674 1.000 41.02941 ?  148 TYR A OH    1 
ATOM   180  N N     . LEU A 1 31  ? -30.95698 -1.93133  -8.66686  1.000 30.72077 ?  149 LEU A N     1 
ATOM   181  C CA    . LEU A 1 31  ? -31.31563 -3.02814  -7.78391  1.000 30.21321 ?  149 LEU A CA    1 
ATOM   182  C C     . LEU A 1 31  ? -30.04372 -3.47197  -7.06921  1.000 31.92474 ?  149 LEU A C     1 
ATOM   183  O O     . LEU A 1 31  ? -28.98181 -3.57071  -7.68542  1.000 33.60122 ?  149 LEU A O     1 
ATOM   184  C CB    . LEU A 1 31  ? -31.93307 -4.16962  -8.58220  1.000 33.27734 ?  149 LEU A CB    1 
ATOM   185  C CG    . LEU A 1 31  ? -32.49174 -5.32169  -7.75880  1.000 36.62380 ?  149 LEU A CG    1 
ATOM   186  C CD1   . LEU A 1 31  ? -33.75919 -4.84547  -7.05339  1.000 35.14105 ?  149 LEU A CD1   1 
ATOM   187  C CD2   . LEU A 1 31  ? -32.83981 -6.42963  -8.72387  1.000 37.29123 ?  149 LEU A CD2   1 
ATOM   188  N N     . ALA A 1 32  ? -30.13024 -3.69076  -5.75610  1.000 30.93695 ?  150 ALA A N     1 
ATOM   189  C CA    . ALA A 1 32  ? -28.94385 -4.05134  -4.99873  1.000 34.91329 ?  150 ALA A CA    1 
ATOM   190  C C     . ALA A 1 32  ? -29.33341 -5.00155  -3.88039  1.000 33.32915 ?  150 ALA A C     1 
ATOM   191  O O     . ALA A 1 32  ? -30.51311 -5.21409  -3.59396  1.000 33.04593 ?  150 ALA A O     1 
ATOM   192  C CB    . ALA A 1 32  ? -28.21377 -2.82039  -4.43746  1.000 32.20128 ?  150 ALA A CB    1 
ATOM   193  N N     . ARG A 1 33  ? -28.30710 -5.59971  -3.26786  1.000 36.74096 ?  151 ARG A N     1 
ATOM   194  C CA    . ARG A 1 33  ? -28.50310 -6.60789  -2.23609  1.000 38.54240 ?  151 ARG A CA    1 
ATOM   195  C C     . ARG A 1 33  ? -27.38193 -6.45877  -1.22069  1.000 37.30595 ?  151 ARG A C     1 
ATOM   196  O O     . ARG A 1 33  ? -26.20720 -6.41590  -1.59768  1.000 39.42391 ?  151 ARG A O     1 
ATOM   197  C CB    . ARG A 1 33  ? -28.49690 -8.02444  -2.83154  1.000 39.13906 ?  151 ARG A CB    1 
ATOM   198  C CG    . ARG A 1 33  ? -28.69369 -9.11512  -1.81910  1.000 42.43881 ?  151 ARG A CG    1 
ATOM   199  C CD    . ARG A 1 33  ? -28.36028 -10.49666 -2.40165  1.000 46.76917 ?  151 ARG A CD    1 
ATOM   200  N NE    . ARG A 1 33  ? -28.88800 -10.67733 -3.75341  1.000 50.75696 ?  151 ARG A NE    1 
ATOM   201  C CZ    . ARG A 1 33  ? -30.08539 -11.16926 -4.05020  1.000 50.32500 ?  151 ARG A CZ    1 
ATOM   202  N NH1   . ARG A 1 33  ? -30.95057 -11.50532 -3.10580  1.000 50.35658 ?  151 ARG A NH1   1 
ATOM   203  N NH2   . ARG A 1 33  ? -30.42360 -11.32399 -5.32978  1.000 46.73989 ?  151 ARG A NH2   1 
ATOM   204  N N     . GLU A 1 34  ? -27.73909 -6.34340  0.04846   1.000 36.08392 ?  152 GLU A N     1 
ATOM   205  C CA    . GLU A 1 34  ? -26.71239 -6.29474  1.07892   1.000 41.29884 ?  152 GLU A CA    1 
ATOM   206  C C     . GLU A 1 34  ? -26.09638 -7.68425  1.23831   1.000 45.28310 ?  152 GLU A C     1 
ATOM   207  O O     . GLU A 1 34  ? -26.81279 -8.68355  1.33156   1.000 44.16145 ?  152 GLU A O     1 
ATOM   208  C CB    . GLU A 1 34  ? -27.30249 -5.79935  2.39319   1.000 43.64553 ?  152 GLU A CB    1 
ATOM   209  C CG    . GLU A 1 34  ? -26.23117 -5.35646  3.37175   1.000 47.98318 ?  152 GLU A CG    1 
ATOM   210  C CD    . GLU A 1 34  ? -25.74110 -6.52021  4.22105   1.000 51.55588 ?  152 GLU A CD    1 
ATOM   211  O OE1   . GLU A 1 34  ? -26.59978 -7.25901  4.75178   1.000 53.47065 ?  152 GLU A OE1   1 
ATOM   212  O OE2   . GLU A 1 34  ? -24.50797 -6.70979  4.33684   1.000 54.49823 -1 152 GLU A OE2   1 
ATOM   213  N N     . LYS A 1 35  ? -24.76381 -7.74815  1.24116   1.000 46.66493 ?  153 LYS A N     1 
ATOM   214  C CA    . LYS A 1 35  ? -24.07723 -9.03225  1.08900   1.000 49.52713 ?  153 LYS A CA    1 
ATOM   215  C C     . LYS A 1 35  ? -24.35962 -9.96798  2.25875   1.000 50.60081 ?  153 LYS A C     1 
ATOM   216  O O     . LYS A 1 35  ? -24.66020 -11.15189 2.06288   1.000 55.63238 ?  153 LYS A O     1 
ATOM   217  C CB    . LYS A 1 35  ? -22.57219 -8.80953  0.92900   1.000 46.83991 ?  153 LYS A CB    1 
ATOM   218  C CG    . LYS A 1 35  ? -22.12395 -8.65827  -0.50214  1.000 46.85963 ?  153 LYS A CG    1 
ATOM   219  C CD    . LYS A 1 35  ? -20.64427 -8.33100  -0.59636  1.000 48.98673 ?  153 LYS A CD    1 
ATOM   220  C CE    . LYS A 1 35  ? -20.35990 -7.41234  -1.76530  1.000 49.90683 ?  153 LYS A CE    1 
ATOM   221  N NZ    . LYS A 1 35  ? -18.89508 -7.30009  -2.06411  1.000 49.40231 ?  153 LYS A NZ    1 
ATOM   222  N N     . GLN A 1 36  ? -24.27361 -9.45840  3.48470   1.000 49.54322 ?  154 GLN A N     1 
ATOM   223  C CA    . GLN A 1 36  ? -24.43471 -10.32641 4.64664   1.000 53.24159 ?  154 GLN A CA    1 
ATOM   224  C C     . GLN A 1 36  ? -25.85531 -10.87555 4.72368   1.000 58.25787 ?  154 GLN A C     1 
ATOM   225  O O     . GLN A 1 36  ? -26.06532 -12.09522 4.77101   1.000 58.40728 ?  154 GLN A O     1 
ATOM   226  C CB    . GLN A 1 36  ? -24.07020 -9.56417  5.92369   1.000 55.54824 ?  154 GLN A CB    1 
ATOM   227  N N     . SER A 1 37  ? -26.85087 -9.98259  4.71229   1.000 52.24595 ?  155 SER A N     1 
ATOM   228  C CA    . SER A 1 37  ? -28.23914 -10.38355 4.90720   1.000 51.83016 ?  155 SER A CA    1 
ATOM   229  C C     . SER A 1 37  ? -28.91177 -10.90759 3.64150   1.000 51.67770 ?  155 SER A C     1 
ATOM   230  O O     . SER A 1 37  ? -29.93667 -11.59245 3.74257   1.000 49.50184 ?  155 SER A O     1 
ATOM   231  C CB    . SER A 1 37  ? -29.03328 -9.19771  5.44377   1.000 51.98102 ?  155 SER A CB    1 
ATOM   232  O OG    . SER A 1 37  ? -29.30307 -8.28344  4.39525   1.000 50.41165 ?  155 SER A OG    1 
ATOM   233  N N     . LYS A 1 38  ? -28.37048 -10.59368 2.46460   1.000 49.76981 ?  156 LYS A N     1 
ATOM   234  C CA    . LYS A 1 38  ? -29.00419 -10.84820 1.17021   1.000 46.73822 ?  156 LYS A CA    1 
ATOM   235  C C     . LYS A 1 38  ? -30.33863 -10.11471 1.01188   1.000 46.06992 ?  156 LYS A C     1 
ATOM   236  O O     . LYS A 1 38  ? -31.16184 -10.48156 0.16365   1.000 44.01704 ?  156 LYS A O     1 
ATOM   237  C CB    . LYS A 1 38  ? -29.15453 -12.34901 0.91194   1.000 50.41169 ?  156 LYS A CB    1 
ATOM   238  C CG    . LYS A 1 38  ? -27.80595 -13.06732 0.96083   1.000 55.28555 ?  156 LYS A CG    1 
ATOM   239  C CD    . LYS A 1 38  ? -27.91618 -14.48600 0.46185   1.000 57.26579 ?  156 LYS A CD    1 
ATOM   240  C CE    . LYS A 1 38  ? -29.01623 -15.21901 1.19721   1.000 60.15237 ?  156 LYS A CE    1 
ATOM   241  N NZ    . LYS A 1 38  ? -28.76974 -15.19293 2.66903   1.000 65.86048 ?  156 LYS A NZ    1 
ATOM   242  N N     . PHE A 1 39  ? -30.52823 -9.03854  1.77405   1.000 45.07342 ?  157 PHE A N     1 
ATOM   243  C CA    . PHE A 1 39  ? -31.69882 -8.17538  1.63711   1.000 43.17242 ?  157 PHE A CA    1 
ATOM   244  C C     . PHE A 1 39  ? -31.66100 -7.37995  0.33768   1.000 39.81636 ?  157 PHE A C     1 
ATOM   245  O O     . PHE A 1 39  ? -30.68772 -6.67386  0.07135   1.000 38.08061 ?  157 PHE A O     1 
ATOM   246  C CB    . PHE A 1 39  ? -31.75903 -7.20640  2.81536   1.000 43.27710 ?  157 PHE A CB    1 
ATOM   247  C CG    . PHE A 1 39  ? -33.09412 -6.54308  2.99917   1.000 46.45365 ?  157 PHE A CG    1 
ATOM   248  C CD1   . PHE A 1 39  ? -34.24611 -7.29844  3.17648   1.000 53.10605 ?  157 PHE A CD1   1 
ATOM   249  C CD2   . PHE A 1 39  ? -33.19369 -5.15523  3.02379   1.000 47.85864 ?  157 PHE A CD2   1 
ATOM   250  C CE1   . PHE A 1 39  ? -35.48825 -6.67856  3.35803   1.000 56.34461 ?  157 PHE A CE1   1 
ATOM   251  C CE2   . PHE A 1 39  ? -34.43290 -4.52367  3.21363   1.000 46.71641 ?  157 PHE A CE2   1 
ATOM   252  C CZ    . PHE A 1 39  ? -35.57810 -5.29184  3.37990   1.000 52.62176 ?  157 PHE A CZ    1 
ATOM   253  N N     . ILE A 1 40  ? -32.74643 -7.44603  -0.43483  1.000 38.38152 ?  158 ILE A N     1 
ATOM   254  C CA    . ILE A 1 40  ? -32.87206 -6.66379  -1.66703  1.000 37.78601 ?  158 ILE A CA    1 
ATOM   255  C C     . ILE A 1 40  ? -33.28765 -5.23492  -1.32258  1.000 36.74368 ?  158 ILE A C     1 
ATOM   256  O O     . ILE A 1 40  ? -34.22075 -5.01540  -0.53809  1.000 37.90073 ?  158 ILE A O     1 
ATOM   257  C CB    . ILE A 1 40  ? -33.88359 -7.31020  -2.62567  1.000 39.13913 ?  158 ILE A CB    1 
ATOM   258  C CG1   . ILE A 1 40  ? -33.37604 -8.65618  -3.12269  1.000 46.19161 ?  158 ILE A CG1   1 
ATOM   259  C CG2   . ILE A 1 40  ? -34.07837 -6.43446  -3.85703  1.000 38.20506 ?  158 ILE A CG2   1 
ATOM   260  C CD1   . ILE A 1 40  ? -32.15140 -8.54439  -3.98464  1.000 46.91089 ?  158 ILE A CD1   1 
ATOM   261  N N     . LEU A 1 41  ? -32.60393 -4.26124  -1.92303  1.000 33.42996 ?  159 LEU A N     1 
ATOM   262  C CA    . LEU A 1 41  ? -32.87059 -2.84734  -1.68408  1.000 32.36333 ?  159 LEU A CA    1 
ATOM   263  C C     . LEU A 1 41  ? -32.58103 -2.05869  -2.96233  1.000 33.30994 ?  159 LEU A C     1 
ATOM   264  O O     . LEU A 1 41  ? -32.10453 -2.60874  -3.95583  1.000 32.43055 ?  159 LEU A O     1 
ATOM   265  C CB    . LEU A 1 41  ? -32.06932 -2.35850  -0.48252  1.000 36.62288 ?  159 LEU A CB    1 
ATOM   266  C CG    . LEU A 1 41  ? -30.57266 -2.66134  -0.49365  1.000 40.85431 ?  159 LEU A CG    1 
ATOM   267  C CD1   . LEU A 1 41  ? -29.79455 -1.61884  -1.27235  1.000 38.15265 ?  159 LEU A CD1   1 
ATOM   268  C CD2   . LEU A 1 41  ? -30.06555 -2.79758  0.94308   1.000 42.27344 ?  159 LEU A CD2   1 
ATOM   269  N N     . ALA A 1 42  ? -32.92394 -0.76637  -2.95111  1.000 29.73037 ?  160 ALA A N     1 
ATOM   270  C CA    . ALA A 1 42  ? -32.69308 0.11535   -4.09478  1.000 33.41308 ?  160 ALA A CA    1 
ATOM   271  C C     . ALA A 1 42  ? -31.55105 1.05306   -3.74493  1.000 34.04688 ?  160 ALA A C     1 
ATOM   272  O O     . ALA A 1 42  ? -31.67669 1.86373   -2.82136  1.000 33.85854 ?  160 ALA A O     1 
ATOM   273  C CB    . ALA A 1 42  ? -33.93911 0.93053   -4.45564  1.000 31.59039 ?  160 ALA A CB    1 
ATOM   274  N N     . LEU A 1 43  ? -30.45680 0.97132   -4.48307  1.000 29.73639 ?  161 LEU A N     1 
ATOM   275  C CA    . LEU A 1 43  ? -29.30750 1.83226   -4.21551  1.000 32.06283 ?  161 LEU A CA    1 
ATOM   276  C C     . LEU A 1 43  ? -29.37187 3.02976   -5.16562  1.000 34.20340 ?  161 LEU A C     1 
ATOM   277  O O     . LEU A 1 43  ? -29.22072 2.87426   -6.38305  1.000 32.95837 ?  161 LEU A O     1 
ATOM   278  C CB    . LEU A 1 43  ? -27.99991 1.06304   -4.38187  1.000 31.53838 ?  161 LEU A CB    1 
ATOM   279  C CG    . LEU A 1 43  ? -26.74911 1.79201   -3.86916  1.000 31.92968 ?  161 LEU A CG    1 
ATOM   280  C CD1   . LEU A 1 43  ? -26.84099 2.01348   -2.37200  1.000 34.41867 ?  161 LEU A CD1   1 
ATOM   281  C CD2   . LEU A 1 43  ? -25.44638 1.05365   -4.23679  1.000 37.18805 ?  161 LEU A CD2   1 
ATOM   282  N N     . LYS A 1 44  ? -29.62077 4.21789   -4.62016  1.000 30.95498 ?  162 LYS A N     1 
ATOM   283  C CA    . LYS A 1 44  ? -29.71915 5.43098   -5.42930  1.000 29.32379 ?  162 LYS A CA    1 
ATOM   284  C C     . LYS A 1 44  ? -28.37394 6.14952   -5.43181  1.000 32.38129 ?  162 LYS A C     1 
ATOM   285  O O     . LYS A 1 44  ? -27.87814 6.56090   -4.37570  1.000 32.39411 ?  162 LYS A O     1 
ATOM   286  C CB    . LYS A 1 44  ? -30.81199 6.35762   -4.89480  1.000 31.76080 ?  162 LYS A CB    1 
ATOM   287  C CG    . LYS A 1 44  ? -31.11492 7.57445   -5.79545  1.000 29.89737 ?  162 LYS A CG    1 
ATOM   288  C CD    . LYS A 1 44  ? -32.50083 8.12637   -5.48427  1.000 30.39301 ?  162 LYS A CD    1 
ATOM   289  C CE    . LYS A 1 44  ? -32.92066 9.22365   -6.48566  1.000 31.97962 ?  162 LYS A CE    1 
ATOM   290  N NZ    . LYS A 1 44  ? -34.37855 9.55410   -6.31531  1.000 28.70987 ?  162 LYS A NZ    1 
ATOM   291  N N     . VAL A 1 45  ? -27.78665 6.30187   -6.61191  1.000 29.93576 ?  163 VAL A N     1 
ATOM   292  C CA    . VAL A 1 45  ? -26.44533 6.86180   -6.75623  1.000 34.30951 ?  163 VAL A CA    1 
ATOM   293  C C     . VAL A 1 45  ? -26.57084 8.23964   -7.38251  1.000 36.47069 ?  163 VAL A C     1 
ATOM   294  O O     . VAL A 1 45  ? -27.05682 8.36912   -8.51440  1.000 38.09765 ?  163 VAL A O     1 
ATOM   295  C CB    . VAL A 1 45  ? -25.54483 5.95409   -7.60969  1.000 35.80724 ?  163 VAL A CB    1 
ATOM   296  C CG1   . VAL A 1 45  ? -24.13202 6.49105   -7.61568  1.000 41.98196 ?  163 VAL A CG1   1 
ATOM   297  C CG2   . VAL A 1 45  ? -25.57462 4.51378   -7.07331  1.000 34.91094 ?  163 VAL A CG2   1 
ATOM   298  N N     . LEU A 1 46  ? -26.11941 9.26510   -6.66334  1.000 34.79730 ?  164 LEU A N     1 
ATOM   299  C CA    . LEU A 1 46  ? -26.12297 10.62987  -7.17066  1.000 37.46216 ?  164 LEU A CA    1 
ATOM   300  C C     . LEU A 1 46  ? -24.69228 11.10818  -7.37735  1.000 40.73286 ?  164 LEU A C     1 
ATOM   301  O O     . LEU A 1 46  ? -23.84741 10.96414  -6.48522  1.000 39.79551 ?  164 LEU A O     1 
ATOM   302  C CB    . LEU A 1 46  ? -26.86999 11.56938  -6.22538  1.000 36.53259 ?  164 LEU A CB    1 
ATOM   303  C CG    . LEU A 1 46  ? -28.28620 11.17513  -5.80035  1.000 35.63851 ?  164 LEU A CG    1 
ATOM   304  C CD1   . LEU A 1 46  ? -28.89741 12.26505  -4.94512  1.000 41.57296 ?  164 LEU A CD1   1 
ATOM   305  C CD2   . LEU A 1 46  ? -29.14321 10.90086  -7.00558  1.000 38.88089 ?  164 LEU A CD2   1 
ATOM   306  N N     . PHE A 1 47  ? -24.42566 11.67565  -8.55161  1.000 39.36254 ?  165 PHE A N     1 
ATOM   307  C CA    . PHE A 1 47  ? -23.08054 12.12953  -8.88077  1.000 40.81635 ?  165 PHE A CA    1 
ATOM   308  C C     . PHE A 1 47  ? -22.84290 13.51300  -8.29802  1.000 40.01505 ?  165 PHE A C     1 
ATOM   309  O O     . PHE A 1 47  ? -23.61469 14.44827  -8.54387  1.000 40.91696 ?  165 PHE A O     1 
ATOM   310  C CB    . PHE A 1 47  ? -22.85016 12.11354  -10.39098 1.000 43.97428 ?  165 PHE A CB    1 
ATOM   311  C CG    . PHE A 1 47  ? -23.40901 10.89783  -11.07942 1.000 45.26825 ?  165 PHE A CG    1 
ATOM   312  C CD1   . PHE A 1 47  ? -22.91662 9.64378   -10.77678 1.000 47.55320 ?  165 PHE A CD1   1 
ATOM   313  C CD2   . PHE A 1 47  ? -24.36127 11.01224  -12.08362 1.000 49.11750 ?  165 PHE A CD2   1 
ATOM   314  C CE1   . PHE A 1 47  ? -23.40814 8.51274   -11.41213 1.000 55.13552 ?  165 PHE A CE1   1 
ATOM   315  C CE2   . PHE A 1 47  ? -24.84483 9.88415   -12.74329 1.000 48.34071 ?  165 PHE A CE2   1 
ATOM   316  C CZ    . PHE A 1 47  ? -24.37719 8.63712   -12.40374 1.000 49.98361 ?  165 PHE A CZ    1 
ATOM   317  N N     . LYS A 1 48  ? -21.78304 13.63086  -7.49575  1.000 42.52422 ?  166 LYS A N     1 
ATOM   318  C CA    . LYS A 1 48  ? -21.48380 14.90584  -6.86169  1.000 42.20467 ?  166 LYS A CA    1 
ATOM   319  C C     . LYS A 1 48  ? -21.27307 15.99631  -7.89352  1.000 43.47885 ?  166 LYS A C     1 
ATOM   320  O O     . LYS A 1 48  ? -21.63859 17.14785  -7.64983  1.000 46.60079 ?  166 LYS A O     1 
ATOM   321  C CB    . LYS A 1 48  ? -20.25637 14.76774  -5.96419  1.000 45.09599 ?  166 LYS A CB    1 
ATOM   322  C CG    . LYS A 1 48  ? -20.52710 13.89957  -4.73831  1.000 45.78809 ?  166 LYS A CG    1 
ATOM   323  C CD    . LYS A 1 48  ? -19.33619 13.89115  -3.79147  1.000 48.35239 ?  166 LYS A CD    1 
ATOM   324  C CE    . LYS A 1 48  ? -19.74108 13.37028  -2.42067  1.000 48.12203 ?  166 LYS A CE    1 
ATOM   325  N NZ    . LYS A 1 48  ? -18.63925 12.59398  -1.79575  1.000 53.18256 ?  166 LYS A NZ    1 
ATOM   326  N N     . ALA A 1 49  ? -20.70999 15.65162  -9.05522  1.000 43.18782 ?  167 ALA A N     1 
ATOM   327  C CA    . ALA A 1 49  ? -20.51978 16.64848  -10.10476 1.000 45.12919 ?  167 ALA A CA    1 
ATOM   328  C C     . ALA A 1 49  ? -21.85264 17.24895  -10.52994 1.000 45.30346 ?  167 ALA A C     1 
ATOM   329  O O     . ALA A 1 49  ? -21.98008 18.46929  -10.68767 1.000 45.32780 ?  167 ALA A O     1 
ATOM   330  C CB    . ALA A 1 49  ? -19.80274 16.02195  -11.30149 1.000 47.29682 ?  167 ALA A CB    1 
ATOM   331  N N     . GLN A 1 50  ? -22.86485 16.39897  -10.71656 1.000 43.10296 ?  168 GLN A N     1 
ATOM   332  C CA    . GLN A 1 50  ? -24.19170 16.88469  -11.08823 1.000 43.73471 ?  168 GLN A CA    1 
ATOM   333  C C     . GLN A 1 50  ? -24.83202 17.69798  -9.97306  1.000 43.64714 ?  168 GLN A C     1 
ATOM   334  O O     . GLN A 1 50  ? -25.44652 18.73697  -10.23683 1.000 45.70195 ?  168 GLN A O     1 
ATOM   335  C CB    . GLN A 1 50  ? -25.09335 15.70998  -11.46132 1.000 42.32274 ?  168 GLN A CB    1 
ATOM   336  C CG    . GLN A 1 50  ? -24.82607 15.10524  -12.81127 1.000 46.61691 ?  168 GLN A CG    1 
ATOM   337  C CD    . GLN A 1 50  ? -25.00588 16.09303  -13.94774 1.000 48.78042 ?  168 GLN A CD    1 
ATOM   338  O OE1   . GLN A 1 50  ? -24.04546 16.45100  -14.62149 1.000 52.58547 ?  168 GLN A OE1   1 
ATOM   339  N NE2   . GLN A 1 50  ? -26.24816 16.52043  -14.17896 1.000 49.85582 ?  168 GLN A NE2   1 
ATOM   340  N N     . LEU A 1 51  ? -24.74064 17.22243  -8.72784  1.000 40.81957 ?  169 LEU A N     1 
ATOM   341  C CA    . LEU A 1 51  ? -25.29859 17.97295  -7.60694  1.000 42.89211 ?  169 LEU A CA    1 
ATOM   342  C C     . LEU A 1 51  ? -24.64537 19.34997  -7.48997  1.000 44.31323 ?  169 LEU A C     1 
ATOM   343  O O     . LEU A 1 51  ? -25.32590 20.34708  -7.21650  1.000 43.58809 ?  169 LEU A O     1 
ATOM   344  C CB    . LEU A 1 51  ? -25.10489 17.18395  -6.30835  1.000 43.19920 ?  169 LEU A CB    1 
ATOM   345  C CG    . LEU A 1 51  ? -25.79090 15.81203  -6.20846  1.000 37.91164 ?  169 LEU A CG    1 
ATOM   346  C CD1   . LEU A 1 51  ? -25.28188 15.03217  -5.01671  1.000 42.15151 ?  169 LEU A CD1   1 
ATOM   347  C CD2   . LEU A 1 51  ? -27.28317 15.95557  -6.12649  1.000 39.04012 ?  169 LEU A CD2   1 
ATOM   348  N N     . GLU A 1 52  ? -23.32058 19.41308  -7.69128  1.000 44.20704 ?  170 GLU A N     1 
ATOM   349  C CA    . GLU A 1 52  ? -22.58425 20.67723  -7.61746  1.000 47.18833 ?  170 GLU A CA    1 
ATOM   350  C C     . GLU A 1 52  ? -22.99386 21.61814  -8.74186  1.000 45.31292 ?  170 GLU A C     1 
ATOM   351  O O     . GLU A 1 52  ? -23.29690 22.79429  -8.50208  1.000 47.77790 ?  170 GLU A O     1 
ATOM   352  C CB    . GLU A 1 52  ? -21.07348 20.41102  -7.67844  1.000 45.40895 ?  170 GLU A CB    1 
ATOM   353  C CG    . GLU A 1 52  ? -20.48174 19.82273  -6.40653  1.000 55.05395 ?  170 GLU A CG    1 
ATOM   354  C CD    . GLU A 1 52  ? -19.08387 19.25315  -6.61684  1.000 58.39407 ?  170 GLU A CD    1 
ATOM   355  O OE1   . GLU A 1 52  ? -18.64719 18.41293  -5.79585  1.000 59.74728 ?  170 GLU A OE1   1 
ATOM   356  O OE2   . GLU A 1 52  ? -18.42883 19.63269  -7.61187  1.000 62.86368 -1 170 GLU A OE2   1 
ATOM   357  N N     . LYS A 1 53  ? -22.99938 21.10787  -9.97834  1.000 47.50649 ?  171 LYS A N     1 
ATOM   358  C CA    . LYS A 1 53  ? -23.41430 21.88774  -11.14360 1.000 47.74223 ?  171 LYS A CA    1 
ATOM   359  C C     . LYS A 1 53  ? -24.78932 22.51069  -10.94219 1.000 49.95903 ?  171 LYS A C     1 
ATOM   360  O O     . LYS A 1 53  ? -25.01019 23.67843  -11.28473 1.000 49.60405 ?  171 LYS A O     1 
ATOM   361  C CB    . LYS A 1 53  ? -23.39505 20.98066  -12.37890 1.000 51.47788 ?  171 LYS A CB    1 
ATOM   362  C CG    . LYS A 1 53  ? -23.06750 21.63880  -13.70258 1.000 55.44809 ?  171 LYS A CG    1 
ATOM   363  C CD    . LYS A 1 53  ? -22.94461 20.58385  -14.82005 1.000 57.01743 ?  171 LYS A CD    1 
ATOM   364  C CE    . LYS A 1 53  ? -24.20929 20.49332  -15.68007 1.000 58.34680 ?  171 LYS A CE    1 
ATOM   365  N NZ    . LYS A 1 53  ? -24.10041 21.16825  -17.02796 1.000 55.16228 ?  171 LYS A NZ    1 
ATOM   366  N N     . ALA A 1 54  ? -25.72616 21.75689  -10.37616 1.000 49.04756 ?  172 ALA A N     1 
ATOM   367  C CA    . ALA A 1 54  ? -27.06504 22.28514  -10.14948 1.000 47.97866 ?  172 ALA A CA    1 
ATOM   368  C C     . ALA A 1 54  ? -27.17550 23.10017  -8.86923  1.000 48.36118 ?  172 ALA A C     1 
ATOM   369  O O     . ALA A 1 54  ? -28.21201 23.73563  -8.64626  1.000 52.06558 ?  172 ALA A O     1 
ATOM   370  C CB    . ALA A 1 54  ? -28.08543 21.14733  -10.11365 1.000 48.09268 ?  172 ALA A CB    1 
ATOM   371  N N     . GLY A 1 55  ? -26.14841 23.09780  -8.02791  1.000 48.68865 ?  173 GLY A N     1 
ATOM   372  C CA    . GLY A 1 55  ? -26.19858 23.84376  -6.78477  1.000 47.77514 ?  173 GLY A CA    1 
ATOM   373  C C     . GLY A 1 55  ? -27.15945 23.30541  -5.74695  1.000 50.46182 ?  173 GLY A C     1 
ATOM   374  O O     . GLY A 1 55  ? -27.67777 24.07774  -4.93689  1.000 49.92224 ?  173 GLY A O     1 
ATOM   375  N N     . VAL A 1 56  ? -27.40384 21.99580  -5.73302  1.000 46.48953 ?  174 VAL A N     1 
ATOM   376  C CA    . VAL A 1 56  ? -28.38751 21.40360  -4.83882  1.000 47.17591 ?  174 VAL A CA    1 
ATOM   377  C C     . VAL A 1 56  ? -27.73141 20.56145  -3.76010  1.000 47.52332 ?  174 VAL A C     1 
ATOM   378  O O     . VAL A 1 56  ? -28.41819 19.80864  -3.06403  1.000 43.77744 ?  174 VAL A O     1 
ATOM   379  C CB    . VAL A 1 56  ? -29.41962 20.57351  -5.61973  1.000 49.24054 ?  174 VAL A CB    1 
ATOM   380  C CG1   . VAL A 1 56  ? -30.25361 21.48088  -6.51282  1.000 45.47974 ?  174 VAL A CG1   1 
ATOM   381  C CG2   . VAL A 1 56  ? -28.71079 19.48889  -6.43079  1.000 44.76280 ?  174 VAL A CG2   1 
ATOM   382  N N     . GLU A 1 57  ? -26.41442 20.66828  -3.60060  1.000 46.85748 ?  175 GLU A N     1 
ATOM   383  C CA    . GLU A 1 57  ? -25.71954 19.78709  -2.67237  1.000 50.41005 ?  175 GLU A CA    1 
ATOM   384  C C     . GLU A 1 57  ? -26.12453 20.08373  -1.22800  1.000 52.46047 ?  175 GLU A C     1 
ATOM   385  O O     . GLU A 1 57  ? -26.15347 19.17379  -0.39166  1.000 53.95343 ?  175 GLU A O     1 
ATOM   386  C CB    . GLU A 1 57  ? -24.20761 19.91085  -2.91427  1.000 53.63516 ?  175 GLU A CB    1 
ATOM   387  C CG    . GLU A 1 57  ? -23.28797 19.09385  -2.01901  1.000 64.06742 ?  175 GLU A CG    1 
ATOM   388  C CD    . GLU A 1 57  ? -21.88983 18.91536  -2.63443  1.000 69.95994 ?  175 GLU A CD    1 
ATOM   389  O OE1   . GLU A 1 57  ? -21.33321 19.90352  -3.16774  1.000 66.64814 ?  175 GLU A OE1   1 
ATOM   390  O OE2   . GLU A 1 57  ? -21.35553 17.77724  -2.60043  1.000 70.78925 -1 175 GLU A OE2   1 
ATOM   391  N N     . HIS A 1 58  ? -26.51958 21.32539  -0.93686  1.000 51.23435 ?  176 HIS A N     1 
ATOM   392  C CA    . HIS A 1 58  ? -26.99830 21.67735  0.39510   1.000 51.58457 ?  176 HIS A CA    1 
ATOM   393  C C     . HIS A 1 58  ? -28.44650 21.24541  0.60178   1.000 50.53189 ?  176 HIS A C     1 
ATOM   394  O O     . HIS A 1 58  ? -28.83266 20.88317  1.72067   1.000 51.09286 ?  176 HIS A O     1 
ATOM   395  C CB    . HIS A 1 58  ? -26.87382 23.19122  0.62064   1.000 56.79214 ?  176 HIS A CB    1 
ATOM   396  C CG    . HIS A 1 58  ? -25.51195 23.63554  1.06059   1.000 61.19630 ?  176 HIS A CG    1 
ATOM   397  N ND1   . HIS A 1 58  ? -25.31200 24.44565  2.15796   1.000 64.21509 ?  176 HIS A ND1   1 
ATOM   398  C CD2   . HIS A 1 58  ? -24.28394 23.39982  0.53873   1.000 61.44464 ?  176 HIS A CD2   1 
ATOM   399  C CE1   . HIS A 1 58  ? -24.01935 24.68046  2.30018   1.000 63.28982 ?  176 HIS A CE1   1 
ATOM   400  N NE2   . HIS A 1 58  ? -23.37377 24.05914  1.32888   1.000 65.92969 ?  176 HIS A NE2   1 
ATOM   401  N N     . GLN A 1 59  ? -29.26224 21.28377  -0.45553  1.000 47.99759 ?  177 GLN A N     1 
ATOM   402  C CA    . GLN A 1 59  ? -30.62777 20.78940  -0.33750  1.000 52.33284 ?  177 GLN A CA    1 
ATOM   403  C C     . GLN A 1 59  ? -30.64710 19.28810  -0.08763  1.000 47.52404 ?  177 GLN A C     1 
ATOM   404  O O     . GLN A 1 59  ? -31.49730 18.78634  0.65660   1.000 47.02927 ?  177 GLN A O     1 
ATOM   405  C CB    . GLN A 1 59  ? -31.43306 21.10217  -1.59484  1.000 52.62184 ?  177 GLN A CB    1 
ATOM   406  C CG    . GLN A 1 59  ? -32.84198 20.51907  -1.51640  1.000 55.10590 ?  177 GLN A CG    1 
ATOM   407  C CD    . GLN A 1 59  ? -33.83478 21.22016  -2.39920  1.000 63.40911 ?  177 GLN A CD    1 
ATOM   408  O OE1   . GLN A 1 59  ? -33.52703 21.55689  -3.54587  1.000 61.34012 ?  177 GLN A OE1   1 
ATOM   409  N NE2   . GLN A 1 59  ? -35.04718 21.42883  -1.88385  1.000 70.02958 ?  177 GLN A NE2   1 
ATOM   410  N N     . LEU A 1 60  ? -29.72344 18.55417  -0.70483  1.000 44.40286 ?  178 LEU A N     1 
ATOM   411  C CA    . LEU A 1 60  ? -29.68498 17.11150  -0.48278  1.000 47.11305 ?  178 LEU A CA    1 
ATOM   412  C C     . LEU A 1 60  ? -29.40555 16.79202  0.98028   1.000 46.68254 ?  178 LEU A C     1 
ATOM   413  O O     . LEU A 1 60  ? -30.01768 15.88093  1.55101   1.000 42.69011 ?  178 LEU A O     1 
ATOM   414  C CB    . LEU A 1 60  ? -28.63666 16.45885  -1.38576  1.000 43.09875 ?  178 LEU A CB    1 
ATOM   415  C CG    . LEU A 1 60  ? -28.47158 14.94491  -1.24158  1.000 42.91347 ?  178 LEU A CG    1 
ATOM   416  C CD1   . LEU A 1 60  ? -29.77516 14.21969  -1.57226  1.000 40.62556 ?  178 LEU A CD1   1 
ATOM   417  C CD2   . LEU A 1 60  ? -27.32875 14.43712  -2.09440  1.000 42.39629 ?  178 LEU A CD2   1 
ATOM   418  N N     . ARG A 1 61  ? -28.48814 17.53786  1.60953   1.000 46.34287 ?  179 ARG A N     1 
ATOM   419  C CA    . ARG A 1 61  ? -28.15576 17.26271  3.00491   1.000 47.47583 ?  179 ARG A CA    1 
ATOM   420  C C     . ARG A 1 61  ? -29.37766 17.41489  3.89543   1.000 49.14752 ?  179 ARG A C     1 
ATOM   421  O O     . ARG A 1 61  ? -29.62253 16.58040  4.77494   1.000 51.49271 ?  179 ARG A O     1 
ATOM   422  C CB    . ARG A 1 61  ? -27.03253 18.18534  3.48002   1.000 51.48181 ?  179 ARG A CB    1 
ATOM   423  N N     . ARG A 1 62  ? -30.17273 18.45940  3.66113   1.000 51.10984 ?  180 ARG A N     1 
ATOM   424  C CA    . ARG A 1 62  ? -31.34522 18.70539  4.49230   1.000 51.44836 ?  180 ARG A CA    1 
ATOM   425  C C     . ARG A 1 62  ? -32.38932 17.61327  4.30520   1.000 51.52529 ?  180 ARG A C     1 
ATOM   426  O O     . ARG A 1 62  ? -32.97081 17.12634  5.28099   1.000 50.52716 ?  180 ARG A O     1 
ATOM   427  C CB    . ARG A 1 62  ? -31.93297 20.08225  4.17465   1.000 51.60489 ?  180 ARG A CB    1 
ATOM   428  N N     . GLU A 1 63  ? -32.62974 17.20119  3.05521   1.000 48.86885 ?  181 GLU A N     1 
ATOM   429  C CA    . GLU A 1 63  ? -33.65521 16.19697  2.79701   1.000 48.51538 ?  181 GLU A CA    1 
ATOM   430  C C     . GLU A 1 63  ? -33.25026 14.81730  3.29073   1.000 47.43779 ?  181 GLU A C     1 
ATOM   431  O O     . GLU A 1 63  ? -34.12099 14.02196  3.64568   1.000 44.73699 ?  181 GLU A O     1 
ATOM   432  C CB    . GLU A 1 63  ? -33.99762 16.13696  1.30841   1.000 49.89894 ?  181 GLU A CB    1 
ATOM   433  C CG    . GLU A 1 63  ? -34.43134 17.47496  0.71749   1.000 54.75116 ?  181 GLU A CG    1 
ATOM   434  C CD    . GLU A 1 63  ? -35.69936 18.00921  1.36451   1.000 61.40490 ?  181 GLU A CD    1 
ATOM   435  O OE1   . GLU A 1 63  ? -36.54329 17.18966  1.79856   1.000 57.19431 ?  181 GLU A OE1   1 
ATOM   436  O OE2   . GLU A 1 63  ? -35.85401 19.25306  1.43733   1.000 67.33201 -1 181 GLU A OE2   1 
ATOM   437  N N     . VAL A 1 64  ? -31.95124 14.50947  3.30149   1.000 44.40913 ?  182 VAL A N     1 
ATOM   438  C CA    . VAL A 1 64  ? -31.49132 13.25929  3.89619   1.000 44.82264 ?  182 VAL A CA    1 
ATOM   439  C C     . VAL A 1 64  ? -31.82420 13.23183  5.38345   1.000 47.74157 ?  182 VAL A C     1 
ATOM   440  O O     . VAL A 1 64  ? -32.27779 12.20986  5.91870   1.000 44.94507 ?  182 VAL A O     1 
ATOM   441  C CB    . VAL A 1 64  ? -29.98175 13.07175  3.64011   1.000 46.33662 ?  182 VAL A CB    1 
ATOM   442  C CG1   . VAL A 1 64  ? -29.37031 12.12145  4.65484   1.000 47.80093 ?  182 VAL A CG1   1 
ATOM   443  C CG2   . VAL A 1 64  ? -29.73841 12.55514  2.21790   1.000 39.99031 ?  182 VAL A CG2   1 
ATOM   444  N N     . GLU A 1 65  ? -31.61512 14.35602  6.07259   1.000 48.38879 ?  183 GLU A N     1 
ATOM   445  C CA    . GLU A 1 65  ? -31.92939 14.40359  7.49611   1.000 47.54945 ?  183 GLU A CA    1 
ATOM   446  C C     . GLU A 1 65  ? -33.42974 14.27492  7.72182   1.000 47.76547 ?  183 GLU A C     1 
ATOM   447  O O     . GLU A 1 65  ? -33.87002 13.55665  8.62788   1.000 49.26809 ?  183 GLU A O     1 
ATOM   448  C CB    . GLU A 1 65  ? -31.39022 15.69658  8.11555   1.000 46.74864 ?  183 GLU A CB    1 
ATOM   449  N N     . ILE A 1 66  ? -34.22773 14.95137  6.89515   1.000 46.31948 ?  184 ILE A N     1 
ATOM   450  C CA    . ILE A 1 66  ? -35.67974 14.83986  6.99494   1.000 46.40436 ?  184 ILE A CA    1 
ATOM   451  C C     . ILE A 1 66  ? -36.10342 13.40365  6.74536   1.000 46.86279 ?  184 ILE A C     1 
ATOM   452  O O     . ILE A 1 66  ? -36.83875 12.79902  7.53546   1.000 44.58360 ?  184 ILE A O     1 
ATOM   453  C CB    . ILE A 1 66  ? -36.35786 15.78913  5.99108   1.000 46.62608 ?  184 ILE A CB    1 
ATOM   454  C CG1   . ILE A 1 66  ? -36.35629 17.22604  6.50764   1.000 51.85876 ?  184 ILE A CG1   1 
ATOM   455  C CG2   . ILE A 1 66  ? -37.79120 15.36305  5.73550   1.000 47.37616 ?  184 ILE A CG2   1 
ATOM   456  C CD1   . ILE A 1 66  ? -36.52571 18.24656  5.38662   1.000 53.63482 ?  184 ILE A CD1   1 
ATOM   457  N N     . GLN A 1 67  ? -35.65529 12.84555  5.61997   1.000 43.27251 ?  185 GLN A N     1 
ATOM   458  C CA    . GLN A 1 67  ? -36.06688 11.50157  5.23886   1.000 46.50804 ?  185 GLN A CA    1 
ATOM   459  C C     . GLN A 1 67  ? -35.65864 10.47535  6.28136   1.000 43.24793 ?  185 GLN A C     1 
ATOM   460  O O     . GLN A 1 67  ? -36.39224 9.50934   6.51452   1.000 43.97795 ?  185 GLN A O     1 
ATOM   461  C CB    . GLN A 1 67  ? -35.47648 11.15641  3.87757   1.000 41.67492 ?  185 GLN A CB    1 
ATOM   462  C CG    . GLN A 1 67  ? -36.10566 9.96389   3.22734   1.000 41.01580 ?  185 GLN A CG    1 
ATOM   463  C CD    . GLN A 1 67  ? -37.47307 10.29648  2.68427   1.000 44.78783 ?  185 GLN A CD    1 
ATOM   464  O OE1   . GLN A 1 67  ? -37.72965 11.42598  2.25188   1.000 42.35613 ?  185 GLN A OE1   1 
ATOM   465  N NE2   . GLN A 1 67  ? -38.34044 9.29722   2.63405   1.000 45.00044 ?  185 GLN A NE2   1 
ATOM   466  N N     . SER A 1 68  ? -34.51401 10.68634  6.93517   1.000 46.27283 ?  186 SER A N     1 
ATOM   467  C CA    . SER A 1 68  ? -34.05696 9.78105   7.98786   1.000 50.24325 ?  186 SER A CA    1 
ATOM   468  C C     . SER A 1 68  ? -35.01621 9.69917   9.16315   1.000 51.79551 ?  186 SER A C     1 
ATOM   469  O O     . SER A 1 68  ? -34.91732 8.75464   9.95252   1.000 56.03604 ?  186 SER A O     1 
ATOM   470  C CB    . SER A 1 68  ? -32.68024 10.20682  8.50915   1.000 50.33962 ?  186 SER A CB    1 
ATOM   471  O OG    . SER A 1 68  ? -31.80810 10.53301  7.44017   1.000 56.09492 ?  186 SER A OG    1 
ATOM   472  N N     . HIS A 1 69  ? -35.91939 10.66774  9.31851   1.000 49.54697 ?  187 HIS A N     1 
ATOM   473  C CA    . HIS A 1 69  ? -36.86684 10.66854  10.42696  1.000 51.70810 ?  187 HIS A CA    1 
ATOM   474  C C     . HIS A 1 69  ? -38.31653 10.49413  9.98987   1.000 51.06609 ?  187 HIS A C     1 
ATOM   475  O O     . HIS A 1 69  ? -39.21850 10.59309  10.82861  1.000 53.40270 ?  187 HIS A O     1 
ATOM   476  C CB    . HIS A 1 69  ? -36.71518 11.94932  11.24433  1.000 56.47282 ?  187 HIS A CB    1 
ATOM   477  C CG    . HIS A 1 69  ? -35.32318 12.17319  11.74300  1.000 59.32242 ?  187 HIS A CG    1 
ATOM   478  N ND1   . HIS A 1 69  ? -34.54742 13.23994  11.34104  1.000 61.67406 ?  187 HIS A ND1   1 
ATOM   479  C CD2   . HIS A 1 69  ? -34.55892 11.45271  12.59874  1.000 64.79302 ?  187 HIS A CD2   1 
ATOM   480  C CE1   . HIS A 1 69  ? -33.36889 13.17304  11.93668  1.000 62.46594 ?  187 HIS A CE1   1 
ATOM   481  N NE2   . HIS A 1 69  ? -33.34983 12.09723  12.70417  1.000 62.89102 ?  187 HIS A NE2   1 
ATOM   482  N N     . LEU A 1 70  ? -38.56845 10.22895  8.70935   1.000 47.74576 ?  188 LEU A N     1 
ATOM   483  C CA    . LEU A 1 70  ? -39.91769 9.94387   8.22966   1.000 48.32398 ?  188 LEU A CA    1 
ATOM   484  C C     . LEU A 1 70  ? -40.11226 8.43325   8.25046   1.000 49.15221 ?  188 LEU A C     1 
ATOM   485  O O     . LEU A 1 70  ? -39.48691 7.71780   7.46095   1.000 49.57507 ?  188 LEU A O     1 
ATOM   486  C CB    . LEU A 1 70  ? -40.12392 10.47690  6.81619   1.000 44.60552 ?  188 LEU A CB    1 
ATOM   487  C CG    . LEU A 1 70  ? -40.15648 11.98576  6.61282   1.000 42.81301 ?  188 LEU A CG    1 
ATOM   488  C CD1   . LEU A 1 70  ? -40.44139 12.27937  5.13992   1.000 43.69704 ?  188 LEU A CD1   1 
ATOM   489  C CD2   . LEU A 1 70  ? -41.17258 12.65956  7.53445   1.000 42.93141 ?  188 LEU A CD2   1 
ATOM   490  N N     . ARG A 1 71  ? -40.99564 7.94374   9.12142   1.000 42.78731 ?  189 ARG A N     1 
ATOM   491  C CA    . ARG A 1 71  ? -41.28260 6.51456   9.20329   1.000 39.06699 ?  189 ARG A CA    1 
ATOM   492  C C     . ARG A 1 71  ? -42.78907 6.31089   9.10502   1.000 42.36403 ?  189 ARG A C     1 
ATOM   493  O O     . ARG A 1 71  ? -43.53270 6.62522   10.04454  1.000 40.82793 ?  189 ARG A O     1 
ATOM   494  C CB    . ARG A 1 71  ? -40.70709 5.91770   10.49279  1.000 47.18383 ?  189 ARG A CB    1 
ATOM   495  N N     . HIS A 1 72  ? -43.24389 5.79653   7.95746   1.000 36.36140 ?  190 HIS A N     1 
ATOM   496  C CA    . HIS A 1 72  ? -44.65988 5.63962   7.64878   1.000 35.28572 ?  190 HIS A CA    1 
ATOM   497  C C     . HIS A 1 72  ? -44.79000 4.53542   6.61474   1.000 36.87475 ?  190 HIS A C     1 
ATOM   498  O O     . HIS A 1 72  ? -43.95070 4.45420   5.70636   1.000 37.48839 ?  190 HIS A O     1 
ATOM   499  C CB    . HIS A 1 72  ? -45.27365 6.93317   7.11003   1.000 36.94403 ?  190 HIS A CB    1 
ATOM   500  C CG    . HIS A 1 72  ? -46.76396 6.90715   7.00502   1.000 34.09320 ?  190 HIS A CG    1 
ATOM   501  N ND1   . HIS A 1 72  ? -47.41969 6.38049   5.91310   1.000 34.79546 ?  190 HIS A ND1   1 
ATOM   502  C CD2   . HIS A 1 72  ? -47.72970 7.36931   7.83608   1.000 37.50652 ?  190 HIS A CD2   1 
ATOM   503  C CE1   . HIS A 1 72  ? -48.72424 6.50669   6.07854   1.000 34.85005 ?  190 HIS A CE1   1 
ATOM   504  N NE2   . HIS A 1 72  ? -48.93855 7.10207   7.23837   1.000 38.27360 ?  190 HIS A NE2   1 
ATOM   505  N N     . PRO A 1 73  ? -45.81159 3.68204   6.71764   1.000 37.96592 ?  191 PRO A N     1 
ATOM   506  C CA    . PRO A 1 73  ? -45.94366 2.57800   5.75355   1.000 38.33178 ?  191 PRO A CA    1 
ATOM   507  C C     . PRO A 1 73  ? -46.12415 3.05347   4.31167   1.000 38.59073 ?  191 PRO A C     1 
ATOM   508  O O     . PRO A 1 73  ? -45.81941 2.30040   3.37932   1.000 35.87062 ?  191 PRO A O     1 
ATOM   509  C CB    . PRO A 1 73  ? -47.18732 1.82328   6.24897   1.000 41.53402 ?  191 PRO A CB    1 
ATOM   510  C CG    . PRO A 1 73  ? -47.94941 2.83282   7.08602   1.000 39.84213 ?  191 PRO A CG    1 
ATOM   511  C CD    . PRO A 1 73  ? -46.88917 3.67999   7.72605   1.000 40.88515 ?  191 PRO A CD    1 
ATOM   512  N N     . ASN A 1 74  ? -46.60672 4.27751   4.09112   1.000 34.68344 ?  192 ASN A N     1 
ATOM   513  C CA    . ASN A 1 74  ? -46.78634 4.76964   2.72981   1.000 33.80575 ?  192 ASN A CA    1 
ATOM   514  C C     . ASN A 1 74  ? -45.74218 5.80900   2.33870   1.000 33.79703 ?  192 ASN A C     1 
ATOM   515  O O     . ASN A 1 74  ? -45.97798 6.61161   1.42557   1.000 30.99236 ?  192 ASN A O     1 
ATOM   516  C CB    . ASN A 1 74  ? -48.19136 5.32858   2.54113   1.000 31.00973 ?  192 ASN A CB    1 
ATOM   517  C CG    . ASN A 1 74  ? -49.25023 4.30063   2.83256   1.000 36.39824 ?  192 ASN A CG    1 
ATOM   518  O OD1   . ASN A 1 74  ? -49.95755 4.42495   3.82315   1.000 36.47286 ?  192 ASN A OD1   1 
ATOM   519  N ND2   . ASN A 1 74  ? -49.33727 3.25595   2.00564   1.000 34.79055 ?  192 ASN A ND2   1 
ATOM   520  N N     . ILE A 1 75  ? -44.58264 5.79865   2.98860   1.000 33.20024 ?  193 ILE A N     1 
ATOM   521  C CA    . ILE A 1 75  ? -43.44733 6.60194   2.56468   1.000 28.58197 ?  193 ILE A CA    1 
ATOM   522  C C     . ILE A 1 75  ? -42.24878 5.68082   2.41407   1.000 34.11196 ?  193 ILE A C     1 
ATOM   523  O O     . ILE A 1 75  ? -41.92224 4.92885   3.33931   1.000 32.13064 ?  193 ILE A O     1 
ATOM   524  C CB    . ILE A 1 75  ? -43.12846 7.73728   3.56071   1.000 33.18374 ?  193 ILE A CB    1 
ATOM   525  C CG1   . ILE A 1 75  ? -44.33443 8.67238   3.72141   1.000 31.71275 ?  193 ILE A CG1   1 
ATOM   526  C CG2   . ILE A 1 75  ? -41.88870 8.52170   3.07590   1.000 33.91141 ?  193 ILE A CG2   1 
ATOM   527  C CD1   . ILE A 1 75  ? -44.12151 9.75521   4.74542   1.000 34.11095 ?  193 ILE A CD1   1 
ATOM   528  N N     . LEU A 1 76  ? -41.59207 5.74368   1.25416   1.000 32.18325 ?  194 LEU A N     1 
ATOM   529  C CA    . LEU A 1 76  ? -40.42544 4.90807   0.99800   1.000 32.07661 ?  194 LEU A CA    1 
ATOM   530  C C     . LEU A 1 76  ? -39.32564 5.20104   2.01637   1.000 34.80618 ?  194 LEU A C     1 
ATOM   531  O O     . LEU A 1 76  ? -38.95434 6.35436   2.23852   1.000 34.06880 ?  194 LEU A O     1 
ATOM   532  C CB    . LEU A 1 76  ? -39.90523 5.15976   -0.41492  1.000 31.76992 ?  194 LEU A CB    1 
ATOM   533  C CG    . LEU A 1 76  ? -39.01259 4.04146   -0.96318  1.000 32.87321 ?  194 LEU A CG    1 
ATOM   534  C CD1   . LEU A 1 76  ? -39.87464 2.82893   -1.35192  1.000 31.78485 ?  194 LEU A CD1   1 
ATOM   535  C CD2   . LEU A 1 76  ? -38.19253 4.55739   -2.14106  1.000 33.16005 ?  194 LEU A CD2   1 
ATOM   536  N N     . ARG A 1 77  ? -38.79029 4.16192   2.63252   1.000 33.61968 ?  195 ARG A N     1 
ATOM   537  C CA    . ARG A 1 77  ? -37.84997 4.37397   3.72303   1.000 34.96566 ?  195 ARG A CA    1 
ATOM   538  C C     . ARG A 1 77  ? -36.42029 4.55847   3.21716   1.000 37.43535 ?  195 ARG A C     1 
ATOM   539  O O     . ARG A 1 77  ? -35.99129 3.91238   2.25318   1.000 33.96404 ?  195 ARG A O     1 
ATOM   540  C CB    . ARG A 1 77  ? -37.91274 3.19971   4.69660   1.000 41.71048 ?  195 ARG A CB    1 
ATOM   541  C CG    . ARG A 1 77  ? -37.21044 3.49374   6.00271   1.000 50.02714 ?  195 ARG A CG    1 
ATOM   542  C CD    . ARG A 1 77  ? -37.67750 2.54310   7.07799   1.000 56.13139 ?  195 ARG A CD    1 
ATOM   543  N NE    . ARG A 1 77  ? -36.55744 2.05536   7.86759   1.000 59.32710 ?  195 ARG A NE    1 
ATOM   544  C CZ    . ARG A 1 77  ? -36.52008 0.86010   8.44008   1.000 64.09199 ?  195 ARG A CZ    1 
ATOM   545  N NH1   . ARG A 1 77  ? -37.52866 0.00719   8.32695   1.000 63.36146 ?  195 ARG A NH1   1 
ATOM   546  N NH2   . ARG A 1 77  ? -35.43586 0.50192   9.12438   1.000 67.27455 ?  195 ARG A NH2   1 
ATOM   547  N N     . LEU A 1 78  ? -35.68806 5.45791   3.86690   1.000 35.06779 ?  196 LEU A N     1 
ATOM   548  C CA    . LEU A 1 78  ? -34.24902 5.59404   3.67954   1.000 35.84457 ?  196 LEU A CA    1 
ATOM   549  C C     . LEU A 1 78  ? -33.56690 4.83575   4.81083   1.000 40.28740 ?  196 LEU A C     1 
ATOM   550  O O     . LEU A 1 78  ? -33.76240 5.16952   5.98447   1.000 38.98973 ?  196 LEU A O     1 
ATOM   551  C CB    . LEU A 1 78  ? -33.82222 7.06268   3.69974   1.000 36.42582 ?  196 LEU A CB    1 
ATOM   552  C CG    . LEU A 1 78  ? -32.29657 7.26702   3.73465   1.000 34.87642 ?  196 LEU A CG    1 
ATOM   553  C CD1   . LEU A 1 78  ? -31.68144 6.78020   2.40885   1.000 35.26827 ?  196 LEU A CD1   1 
ATOM   554  C CD2   . LEU A 1 78  ? -31.92562 8.69901   4.00262   1.000 41.48220 ?  196 LEU A CD2   1 
ATOM   555  N N     . TYR A 1 79  ? -32.78757 3.81065   4.45890   1.000 38.32376 ?  197 TYR A N     1 
ATOM   556  C CA    . TYR A 1 79  ? -32.14894 2.94106   5.44250   1.000 37.34917 ?  197 TYR A CA    1 
ATOM   557  C C     . TYR A 1 79  ? -30.83334 3.53742   5.91715   1.000 41.90631 ?  197 TYR A C     1 
ATOM   558  O O     . TYR A 1 79  ? -30.43276 3.35367   7.07473   1.000 40.97087 ?  197 TYR A O     1 
ATOM   559  C CB    . TYR A 1 79  ? -31.92014 1.57762   4.78928   1.000 36.73264 ?  197 TYR A CB    1 
ATOM   560  C CG    . TYR A 1 79  ? -33.20146 0.78774   4.66899   1.000 39.13053 ?  197 TYR A CG    1 
ATOM   561  C CD1   . TYR A 1 79  ? -33.47509 0.04133   3.52343   1.000 42.63365 ?  197 TYR A CD1   1 
ATOM   562  C CD2   . TYR A 1 79  ? -34.10859 0.73785   5.71007   1.000 50.65966 ?  197 TYR A CD2   1 
ATOM   563  C CE1   . TYR A 1 79  ? -34.65688 -0.66968  3.39859   1.000 43.13802 ?  197 TYR A CE1   1 
ATOM   564  C CE2   . TYR A 1 79  ? -35.27589 0.01086   5.60139   1.000 53.90297 ?  197 TYR A CE2   1 
ATOM   565  C CZ    . TYR A 1 79  ? -35.54693 -0.68678  4.45036   1.000 48.05246 ?  197 TYR A CZ    1 
ATOM   566  O OH    . TYR A 1 79  ? -36.71859 -1.40753  4.36808   1.000 54.86851 ?  197 TYR A OH    1 
ATOM   567  N N     . GLY A 1 80  ? -30.16598 4.26576   5.04330   1.000 35.82280 ?  198 GLY A N     1 
ATOM   568  C CA    . GLY A 1 80  ? -28.88045 4.84245   5.36347   1.000 38.11683 ?  198 GLY A CA    1 
ATOM   569  C C     . GLY A 1 80  ? -28.30810 5.45434   4.11252   1.000 38.73027 ?  198 GLY A C     1 
ATOM   570  O O     . GLY A 1 80  ? -28.94552 5.46479   3.04862   1.000 37.59892 ?  198 GLY A O     1 
ATOM   571  N N     . TYR A 1 81  ? -27.08232 5.94696   4.25046   1.000 37.01135 ?  199 TYR A N     1 
ATOM   572  C CA    . TYR A 1 81  ? -26.41961 6.64132   3.15935   1.000 39.53791 ?  199 TYR A CA    1 
ATOM   573  C C     . TYR A 1 81  ? -24.92860 6.70467   3.44696   1.000 43.16318 ?  199 TYR A C     1 
ATOM   574  O O     . TYR A 1 81  ? -24.48541 6.50014   4.58111   1.000 38.72754 ?  199 TYR A O     1 
ATOM   575  C CB    . TYR A 1 81  ? -26.98760 8.05251   2.96678   1.000 41.32713 ?  199 TYR A CB    1 
ATOM   576  C CG    . TYR A 1 81  ? -26.94357 8.88062   4.22931   1.000 42.29120 ?  199 TYR A CG    1 
ATOM   577  C CD1   . TYR A 1 81  ? -27.94901 8.79015   5.17451   1.000 47.01844 ?  199 TYR A CD1   1 
ATOM   578  C CD2   . TYR A 1 81  ? -25.87654 9.73629   4.48275   1.000 50.21838 ?  199 TYR A CD2   1 
ATOM   579  C CE1   . TYR A 1 81  ? -27.90593 9.53568   6.34444   1.000 48.52350 ?  199 TYR A CE1   1 
ATOM   580  C CE2   . TYR A 1 81  ? -25.82334 10.48604  5.64593   1.000 52.25961 ?  199 TYR A CE2   1 
ATOM   581  C CZ    . TYR A 1 81  ? -26.84124 10.37901  6.57095   1.000 52.84985 ?  199 TYR A CZ    1 
ATOM   582  O OH    . TYR A 1 81  ? -26.79529 11.13283  7.72497   1.000 59.05729 ?  199 TYR A OH    1 
ATOM   583  N N     . PHE A 1 82  ? -24.16418 6.99358   2.39679   1.000 39.06934 ?  200 PHE A N     1 
ATOM   584  C CA    . PHE A 1 82  ? -22.71850 7.15185   2.48005   1.000 42.22962 ?  200 PHE A CA    1 
ATOM   585  C C     . PHE A 1 82  ? -22.26780 7.85467   1.20465   1.000 41.97679 ?  200 PHE A C     1 
ATOM   586  O O     . PHE A 1 82  ? -23.07862 8.17207   0.33224   1.000 40.21306 ?  200 PHE A O     1 
ATOM   587  C CB    . PHE A 1 82  ? -22.00941 5.80225   2.69062   1.000 39.84499 ?  200 PHE A CB    1 
ATOM   588  C CG    . PHE A 1 82  ? -22.30696 4.75839   1.63033   1.000 41.53553 ?  200 PHE A CG    1 
ATOM   589  C CD1   . PHE A 1 82  ? -23.49119 4.03737   1.64296   1.000 40.62770 ?  200 PHE A CD1   1 
ATOM   590  C CD2   . PHE A 1 82  ? -21.38400 4.49071   0.63112   1.000 42.81644 ?  200 PHE A CD2   1 
ATOM   591  C CE1   . PHE A 1 82  ? -23.74202 3.06792   0.67233   1.000 41.66800 ?  200 PHE A CE1   1 
ATOM   592  C CE2   . PHE A 1 82  ? -21.63882 3.51834   -0.34580  1.000 41.30496 ?  200 PHE A CE2   1 
ATOM   593  C CZ    . PHE A 1 82  ? -22.80836 2.81533   -0.31500  1.000 41.32551 ?  200 PHE A CZ    1 
ATOM   594  N N     . HIS A 1 83  ? -20.96657 8.10313   1.09820   1.000 41.74166 ?  201 HIS A N     1 
ATOM   595  C CA    . HIS A 1 83  ? -20.43436 8.80530   -0.05985  1.000 43.69318 ?  201 HIS A CA    1 
ATOM   596  C C     . HIS A 1 83  ? -19.02174 8.31707   -0.33515  1.000 47.12037 ?  201 HIS A C     1 
ATOM   597  O O     . HIS A 1 83  ? -18.37176 7.71011   0.52343   1.000 48.18365 ?  201 HIS A O     1 
ATOM   598  C CB    . HIS A 1 83  ? -20.43510 10.32661  0.15677   1.000 46.40489 ?  201 HIS A CB    1 
ATOM   599  C CG    . HIS A 1 83  ? -19.62077 10.76149  1.33729   1.000 50.41534 ?  201 HIS A CG    1 
ATOM   600  N ND1   . HIS A 1 83  ? -18.25319 10.92394  1.28086   1.000 54.27297 ?  201 HIS A ND1   1 
ATOM   601  C CD2   . HIS A 1 83  ? -19.97804 11.02663  2.61600   1.000 50.88033 ?  201 HIS A CD2   1 
ATOM   602  C CE1   . HIS A 1 83  ? -17.80643 11.29479  2.46898   1.000 52.84974 ?  201 HIS A CE1   1 
ATOM   603  N NE2   . HIS A 1 83  ? -18.83329 11.36287  3.29723   1.000 52.76110 ?  201 HIS A NE2   1 
ATOM   604  N N     . ASP A 1 84  ? -18.55835 8.56814   -1.55238  1.000 45.21081 ?  202 ASP A N     1 
ATOM   605  C CA    . ASP A 1 84  ? -17.14313 8.42300   -1.86980  1.000 48.93245 ?  202 ASP A CA    1 
ATOM   606  C C     . ASP A 1 84  ? -16.70295 9.72206   -2.53743  1.000 50.46727 ?  202 ASP A C     1 
ATOM   607  O O     . ASP A 1 84  ? -17.32713 10.77935  -2.36641  1.000 49.10732 ?  202 ASP A O     1 
ATOM   608  C CB    . ASP A 1 84  ? -16.88481 7.12076   -2.65129  1.000 46.44834 ?  202 ASP A CB    1 
ATOM   609  C CG    . ASP A 1 84  ? -17.49473 7.10905   -4.04489  1.000 48.73399 ?  202 ASP A CG    1 
ATOM   610  O OD1   . ASP A 1 84  ? -17.95328 8.15850   -4.54610  1.000 47.76585 ?  202 ASP A OD1   1 
ATOM   611  O OD2   . ASP A 1 84  ? -17.53379 6.00418   -4.63089  1.000 48.94116 -1 202 ASP A OD2   1 
ATOM   612  N N     . ALA A 1 85  ? -15.59526 9.66264   -3.27952  1.000 48.58503 ?  203 ALA A N     1 
ATOM   613  C CA    . ALA A 1 85  ? -15.01906 10.88809  -3.82376  1.000 51.37946 ?  203 ALA A CA    1 
ATOM   614  C C     . ALA A 1 85  ? -15.93259 11.54341  -4.85101  1.000 50.20016 ?  203 ALA A C     1 
ATOM   615  O O     . ALA A 1 85  ? -15.93198 12.77141  -4.98221  1.000 50.07112 ?  203 ALA A O     1 
ATOM   616  C CB    . ALA A 1 85  ? -13.65168 10.59523  -4.44432  1.000 50.50300 ?  203 ALA A CB    1 
ATOM   617  N N     . THR A 1 86  ? -16.72554 10.75480  -5.57697  1.000 48.08316 ?  204 THR A N     1 
ATOM   618  C CA    . THR A 1 86  ? -17.48836 11.26994  -6.70733  1.000 45.49606 ?  204 THR A CA    1 
ATOM   619  C C     . THR A 1 86  ? -18.99841 11.08801  -6.60420  1.000 44.12647 ?  204 THR A C     1 
ATOM   620  O O     . THR A 1 86  ? -19.72143 11.59290  -7.47113  1.000 45.54452 ?  204 THR A O     1 
ATOM   621  C CB    . THR A 1 86  ? -17.00697 10.59324  -7.99613  1.000 45.21262 ?  204 THR A CB    1 
ATOM   622  O OG1   . THR A 1 86  ? -17.23375 9.18112   -7.88201  1.000 47.54956 ?  204 THR A OG1   1 
ATOM   623  C CG2   . THR A 1 86  ? -15.52249 10.85559  -8.21474  1.000 49.25611 ?  204 THR A CG2   1 
ATOM   624  N N     . ARG A 1 87  ? -19.49766 10.39709  -5.58507  1.000 42.26220 ?  205 ARG A N     1 
ATOM   625  C CA    . ARG A 1 87  ? -20.87154 9.92129   -5.59397  1.000 41.90881 ?  205 ARG A CA    1 
ATOM   626  C C     . ARG A 1 87  ? -21.44407 9.97231   -4.18915  1.000 39.25237 ?  205 ARG A C     1 
ATOM   627  O O     . ARG A 1 87  ? -20.71495 9.81459   -3.20833  1.000 43.52434 ?  205 ARG A O     1 
ATOM   628  C CB    . ARG A 1 87  ? -20.91416 8.48575   -6.11206  1.000 41.35675 ?  205 ARG A CB    1 
ATOM   629  C CG    . ARG A 1 87  ? -20.58833 8.27568   -7.59708  1.000 44.02057 ?  205 ARG A CG    1 
ATOM   630  C CD    . ARG A 1 87  ? -20.21250 6.82148   -7.75140  1.000 47.16718 ?  205 ARG A CD    1 
ATOM   631  N NE    . ARG A 1 87  ? -20.95410 6.09434   -8.77007  1.000 60.16646 ?  205 ARG A NE    1 
ATOM   632  C CZ    . ARG A 1 87  ? -20.78221 4.80238   -9.02857  1.000 64.32463 ?  205 ARG A CZ    1 
ATOM   633  N NH1   . ARG A 1 87  ? -19.85718 4.08833   -8.39825  1.000 60.51299 ?  205 ARG A NH1   1 
ATOM   634  N NH2   . ARG A 1 87  ? -21.58173 4.20348   -9.91256  1.000 60.41902 ?  205 ARG A NH2   1 
ATOM   635  N N     . VAL A 1 88  ? -22.76092 10.16410  -4.10093  1.000 39.57672 ?  206 VAL A N     1 
ATOM   636  C CA    . VAL A 1 88  ? -23.51706 9.97900   -2.86245  1.000 35.64515 ?  206 VAL A CA    1 
ATOM   637  C C     . VAL A 1 88  ? -24.42281 8.76860   -3.05933  1.000 40.22090 ?  206 VAL A C     1 
ATOM   638  O O     . VAL A 1 88  ? -25.02749 8.60669   -4.12668  1.000 37.64132 ?  206 VAL A O     1 
ATOM   639  C CB    . VAL A 1 88  ? -24.35472 11.22002  -2.48650  1.000 37.03809 ?  206 VAL A CB    1 
ATOM   640  C CG1   . VAL A 1 88  ? -25.26759 10.90910  -1.28024  1.000 38.33338 ?  206 VAL A CG1   1 
ATOM   641  C CG2   . VAL A 1 88  ? -23.47059 12.43762  -2.22074  1.000 42.74684 ?  206 VAL A CG2   1 
ATOM   642  N N     . TYR A 1 89  ? -24.51855 7.92094   -2.03629  1.000 35.25835 ?  207 TYR A N     1 
ATOM   643  C CA    . TYR A 1 89  ? -25.27569 6.67682   -2.10648  1.000 36.57352 ?  207 TYR A CA    1 
ATOM   644  C C     . TYR A 1 89  ? -26.39667 6.73914   -1.08837  1.000 38.15251 ?  207 TYR A C     1 
ATOM   645  O O     . TYR A 1 89  ? -26.13498 6.91039   0.10824   1.000 36.86212 ?  207 TYR A O     1 
ATOM   646  C CB    . TYR A 1 89  ? -24.39397 5.46104   -1.80986  1.000 36.57327 ?  207 TYR A CB    1 
ATOM   647  C CG    . TYR A 1 89  ? -23.23550 5.29666   -2.75603  1.000 41.45965 ?  207 TYR A CG    1 
ATOM   648  C CD1   . TYR A 1 89  ? -22.01693 5.92886   -2.51227  1.000 42.71765 ?  207 TYR A CD1   1 
ATOM   649  C CD2   . TYR A 1 89  ? -23.35697 4.51632   -3.89714  1.000 38.81954 ?  207 TYR A CD2   1 
ATOM   650  C CE1   . TYR A 1 89  ? -20.94865 5.78024   -3.38321  1.000 42.94823 ?  207 TYR A CE1   1 
ATOM   651  C CE2   . TYR A 1 89  ? -22.30460 4.37344   -4.77910  1.000 41.10795 ?  207 TYR A CE2   1 
ATOM   652  C CZ    . TYR A 1 89  ? -21.10274 4.99900   -4.51565  1.000 44.90904 ?  207 TYR A CZ    1 
ATOM   653  O OH    . TYR A 1 89  ? -20.05134 4.83774   -5.39004  1.000 46.89325 ?  207 TYR A OH    1 
ATOM   654  N N     . LEU A 1 90  ? -27.63297 6.59968   -1.55953  1.000 35.51748 ?  208 LEU A N     1 
ATOM   655  C CA    . LEU A 1 90  ? -28.80812 6.51174   -0.70448  1.000 35.57021 ?  208 LEU A CA    1 
ATOM   656  C C     . LEU A 1 90  ? -29.28489 5.06488   -0.72093  1.000 34.55030 ?  208 LEU A C     1 
ATOM   657  O O     . LEU A 1 90  ? -29.57475 4.51227   -1.78715  1.000 32.31207 ?  208 LEU A O     1 
ATOM   658  C CB    . LEU A 1 90  ? -29.90798 7.45932   -1.18815  1.000 33.05284 ?  208 LEU A CB    1 
ATOM   659  C CG    . LEU A 1 90  ? -29.42752 8.88449   -1.47120  1.000 33.89229 ?  208 LEU A CG    1 
ATOM   660  C CD1   . LEU A 1 90  ? -30.54730 9.72643   -2.08435  1.000 34.35847 ?  208 LEU A CD1   1 
ATOM   661  C CD2   . LEU A 1 90  ? -28.93103 9.52393   -0.17320  1.000 35.83333 ?  208 LEU A CD2   1 
ATOM   662  N N     . ILE A 1 91  ? -29.37128 4.45624   0.45344   1.000 33.02230 ?  209 ILE A N     1 
ATOM   663  C CA    . ILE A 1 91  ? -29.78750 3.06759   0.57617   1.000 32.55769 ?  209 ILE A CA    1 
ATOM   664  C C     . ILE A 1 91  ? -31.28362 3.08830   0.85448   1.000 35.20243 ?  209 ILE A C     1 
ATOM   665  O O     . ILE A 1 91  ? -31.71481 3.36639   1.98330   1.000 32.55823 ?  209 ILE A O     1 
ATOM   666  C CB    . ILE A 1 91  ? -29.00498 2.34195   1.67529   1.000 32.96504 ?  209 ILE A CB    1 
ATOM   667  C CG1   . ILE A 1 91  ? -27.49752 2.49808   1.42413   1.000 36.15734 ?  209 ILE A CG1   1 
ATOM   668  C CG2   . ILE A 1 91  ? -29.43167 0.88370   1.76214   1.000 37.50627 ?  209 ILE A CG2   1 
ATOM   669  C CD1   . ILE A 1 91  ? -26.62275 2.24059   2.66934   1.000 42.20179 ?  209 ILE A CD1   1 
ATOM   670  N N     . LEU A 1 92  ? -32.07900 2.77915   -0.17723  1.000 33.20791 ?  210 LEU A N     1 
ATOM   671  C CA    . LEU A 1 92  ? -33.52275 2.95931   -0.15229  1.000 30.61510 ?  210 LEU A CA    1 
ATOM   672  C C     . LEU A 1 92  ? -34.25327 1.62085   -0.08747  1.000 34.02949 ?  210 LEU A C     1 
ATOM   673  O O     . LEU A 1 92  ? -33.78809 0.59715   -0.60399  1.000 34.00357 ?  210 LEU A O     1 
ATOM   674  C CB    . LEU A 1 92  ? -34.00695 3.71874   -1.40772  1.000 30.06694 ?  210 LEU A CB    1 
ATOM   675  C CG    . LEU A 1 92  ? -33.49294 5.15008   -1.60215  1.000 32.57518 ?  210 LEU A CG    1 
ATOM   676  C CD1   . LEU A 1 92  ? -33.97186 5.76582   -2.92689  1.000 31.49735 ?  210 LEU A CD1   1 
ATOM   677  C CD2   . LEU A 1 92  ? -33.92125 5.98917   -0.42054  1.000 36.32415 ?  210 LEU A CD2   1 
ATOM   678  N N     . GLU A 1 93  ? -35.42152 1.64926   0.53728   1.000 31.58396 ?  211 GLU A N     1 
ATOM   679  C CA    . GLU A 1 93  ? -36.36712 0.55656   0.41160   1.000 33.89456 ?  211 GLU A CA    1 
ATOM   680  C C     . GLU A 1 93  ? -36.64083 0.29062   -1.06905  1.000 34.82280 ?  211 GLU A C     1 
ATOM   681  O O     . GLU A 1 93  ? -36.81217 1.21941   -1.86297  1.000 30.34504 ?  211 GLU A O     1 
ATOM   682  C CB    . GLU A 1 93  ? -37.65975 0.91711   1.15651   1.000 32.98744 ?  211 GLU A CB    1 
ATOM   683  C CG    . GLU A 1 93  ? -38.79582 -0.05744  1.01112   1.000 34.32023 ?  211 GLU A CG    1 
ATOM   684  C CD    . GLU A 1 93  ? -40.06834 0.42138   1.71032   1.000 36.59852 ?  211 GLU A CD    1 
ATOM   685  O OE1   . GLU A 1 93  ? -40.06626 1.51483   2.33161   1.000 34.55008 ?  211 GLU A OE1   1 
ATOM   686  O OE2   . GLU A 1 93  ? -41.07415 -0.29737  1.63428   1.000 36.97077 -1 211 GLU A OE2   1 
ATOM   687  N N     . TYR A 1 94  ? -36.63972 -0.98367  -1.44554  1.000 29.49836 ?  212 TYR A N     1 
ATOM   688  C CA    . TYR A 1 94  ? -37.02198 -1.39838  -2.79005  1.000 31.53027 ?  212 TYR A CA    1 
ATOM   689  C C     . TYR A 1 94  ? -38.51985 -1.69436  -2.82611  1.000 33.58384 ?  212 TYR A C     1 
ATOM   690  O O     . TYR A 1 94  ? -39.03048 -2.46031  -2.00456  1.000 34.25724 ?  212 TYR A O     1 
ATOM   691  C CB    . TYR A 1 94  ? -36.20318 -2.62550  -3.18980  1.000 32.02922 ?  212 TYR A CB    1 
ATOM   692  C CG    . TYR A 1 94  ? -36.67183 -3.37391  -4.39903  1.000 32.81216 ?  212 TYR A CG    1 
ATOM   693  C CD1   . TYR A 1 94  ? -36.57287 -2.82061  -5.67487  1.000 34.70699 ?  212 TYR A CD1   1 
ATOM   694  C CD2   . TYR A 1 94  ? -37.12991 -4.67501  -4.28224  1.000 34.71974 ?  212 TYR A CD2   1 
ATOM   695  C CE1   . TYR A 1 94  ? -36.99797 -3.53752  -6.79331  1.000 33.80246 ?  212 TYR A CE1   1 
ATOM   696  C CE2   . TYR A 1 94  ? -37.55584 -5.39343  -5.39450  1.000 38.53123 ?  212 TYR A CE2   1 
ATOM   697  C CZ    . TYR A 1 94  ? -37.47486 -4.82650  -6.63967  1.000 35.33114 ?  212 TYR A CZ    1 
ATOM   698  O OH    . TYR A 1 94  ? -37.88280 -5.56816  -7.72456  1.000 39.50562 ?  212 TYR A OH    1 
ATOM   699  N N     . ALA A 1 95  ? -39.22920 -1.07599  -3.77787  1.000 32.71318 ?  213 ALA A N     1 
ATOM   700  C CA    . ALA A 1 95  ? -40.64555 -1.33343  -3.96875  1.000 29.42108 ?  213 ALA A CA    1 
ATOM   701  C C     . ALA A 1 95  ? -40.81137 -2.28462  -5.13771  1.000 34.21946 ?  213 ALA A C     1 
ATOM   702  O O     . ALA A 1 95  ? -40.63160 -1.86118  -6.29078  1.000 34.35716 ?  213 ALA A O     1 
ATOM   703  C CB    . ALA A 1 95  ? -41.41432 -0.02994  -4.23509  1.000 34.95448 ?  213 ALA A CB    1 
ATOM   704  N N     . PRO A 1 96  ? -41.20332 -3.54582  -4.91205  1.000 32.24119 ?  214 PRO A N     1 
ATOM   705  C CA    . PRO A 1 96  ? -41.03939 -4.56289  -5.96700  1.000 35.33539 ?  214 PRO A CA    1 
ATOM   706  C C     . PRO A 1 96  ? -41.99016 -4.40988  -7.14049  1.000 34.72556 ?  214 PRO A C     1 
ATOM   707  O O     . PRO A 1 96  ? -41.72651 -4.99662  -8.19890  1.000 34.03293 ?  214 PRO A O     1 
ATOM   708  C CB    . PRO A 1 96  ? -41.30449 -5.88827  -5.22897  1.000 37.63780 ?  214 PRO A CB    1 
ATOM   709  C CG    . PRO A 1 96  ? -41.18165 -5.55533  -3.75061  1.000 39.45649 ?  214 PRO A CG    1 
ATOM   710  C CD    . PRO A 1 96  ? -41.67453 -4.13905  -3.64993  1.000 37.60411 ?  214 PRO A CD    1 
ATOM   711  N N     . LEU A 1 97  ? -43.10625 -3.69136  -7.00532  1.000 32.29179 ?  215 LEU A N     1 
ATOM   712  C CA    . LEU A 1 97  ? -44.07929 -3.67195  -8.09289  1.000 29.99598 ?  215 LEU A CA    1 
ATOM   713  C C     . LEU A 1 97  ? -43.98149 -2.42608  -8.98170  1.000 34.96631 ?  215 LEU A C     1 
ATOM   714  O O     . LEU A 1 97  ? -44.85117 -2.22777  -9.83836  1.000 34.53079 ?  215 LEU A O     1 
ATOM   715  C CB    . LEU A 1 97  ? -45.50175 -3.82389  -7.53788  1.000 34.68361 ?  215 LEU A CB    1 
ATOM   716  C CG    . LEU A 1 97  ? -45.80850 -5.13277  -6.79300  1.000 41.07296 ?  215 LEU A CG    1 
ATOM   717  C CD1   . LEU A 1 97  ? -47.24807 -5.17593  -6.29456  1.000 43.02899 ?  215 LEU A CD1   1 
ATOM   718  C CD2   . LEU A 1 97  ? -45.48485 -6.35541  -7.64232  1.000 42.45791 ?  215 LEU A CD2   1 
ATOM   719  N N     . GLY A 1 98  ? -42.95114 -1.58563  -8.81370  1.000 29.29322 ?  216 GLY A N     1 
ATOM   720  C CA    . GLY A 1 98  ? -42.73745 -0.48660  -9.77173  1.000 31.97933 ?  216 GLY A CA    1 
ATOM   721  C C     . GLY A 1 98  ? -43.58138 0.74410   -9.46906  1.000 32.29914 ?  216 GLY A C     1 
ATOM   722  O O     . GLY A 1 98  ? -44.11172 0.89413   -8.36890  1.000 30.00031 ?  216 GLY A O     1 
ATOM   723  N N     . THR A 1 99  ? -43.68408 1.65086   -10.45465 1.000 31.78246 ?  217 THR A N     1 
ATOM   724  C CA    . THR A 1 99  ? -44.39579 2.90930   -10.21817 1.000 29.57202 ?  217 THR A CA    1 
ATOM   725  C C     . THR A 1 99  ? -45.88884 2.75647   -10.47650 1.000 30.75376 ?  217 THR A C     1 
ATOM   726  O O     . THR A 1 99  ? -46.34637 1.88784   -11.22810 1.000 29.71057 ?  217 THR A O     1 
ATOM   727  C CB    . THR A 1 99  ? -43.86374 4.04972   -11.10146 1.000 29.25740 ?  217 THR A CB    1 
ATOM   728  O OG1   . THR A 1 99  ? -44.20156 3.79356   -12.46483 1.000 30.88096 ?  217 THR A OG1   1 
ATOM   729  C CG2   . THR A 1 99  ? -42.33133 4.18587   -10.97145 1.000 27.35422 ?  217 THR A CG2   1 
ATOM   730  N N     . VAL A 1 100 ? -46.65883 3.64151   -9.84744  1.000 27.95100 ?  218 VAL A N     1 
ATOM   731  C CA    . VAL A 1 100 ? -48.07115 3.73394   -10.19370 1.000 29.05034 ?  218 VAL A CA    1 
ATOM   732  C C     . VAL A 1 100 ? -48.23313 4.24794   -11.60884 1.000 29.79667 ?  218 VAL A C     1 
ATOM   733  O O     . VAL A 1 100 ? -49.20398 3.90343   -12.29201 1.000 32.34792 ?  218 VAL A O     1 
ATOM   734  C CB    . VAL A 1 100 ? -48.80964 4.64242   -9.18929  1.000 30.63101 ?  218 VAL A CB    1 
ATOM   735  C CG1   . VAL A 1 100 ? -50.30714 4.66828   -9.51275  1.000 32.94102 ?  218 VAL A CG1   1 
ATOM   736  C CG2   . VAL A 1 100 ? -48.61477 4.09492   -7.83187  1.000 32.79168 ?  218 VAL A CG2   1 
ATOM   737  N N     . TYR A 1 101 ? -47.31297 5.10854   -12.05752 1.000 29.50868 ?  219 TYR A N     1 
ATOM   738  C CA    . TYR A 1 101 ? -47.33538 5.57418   -13.44193 1.000 29.22792 ?  219 TYR A CA    1 
ATOM   739  C C     . TYR A 1 101 ? -47.35856 4.40009   -14.40521 1.000 31.01963 ?  219 TYR A C     1 
ATOM   740  O O     . TYR A 1 101 ? -48.13258 4.38938   -15.37211 1.000 30.81961 ?  219 TYR A O     1 
ATOM   741  C CB    . TYR A 1 101 ? -46.12434 6.46983   -13.69982 1.000 30.53762 ?  219 TYR A CB    1 
ATOM   742  C CG    . TYR A 1 101 ? -45.91659 6.83461   -15.16261 1.000 34.87181 ?  219 TYR A CG    1 
ATOM   743  C CD1   . TYR A 1 101 ? -46.61061 7.89461   -15.74700 1.000 35.64310 ?  219 TYR A CD1   1 
ATOM   744  C CD2   . TYR A 1 101 ? -45.01651 6.13174   -15.94557 1.000 38.04846 ?  219 TYR A CD2   1 
ATOM   745  C CE1   . TYR A 1 101 ? -46.40791 8.23716   -17.09703 1.000 37.37893 ?  219 TYR A CE1   1 
ATOM   746  C CE2   . TYR A 1 101 ? -44.80616 6.45380   -17.27914 1.000 37.15729 ?  219 TYR A CE2   1 
ATOM   747  C CZ    . TYR A 1 101 ? -45.49360 7.50095   -17.84531 1.000 41.05857 ?  219 TYR A CZ    1 
ATOM   748  O OH    . TYR A 1 101 ? -45.25000 7.79558   -19.16703 1.000 40.64177 ?  219 TYR A OH    1 
ATOM   749  N N     . ARG A 1 102 ? -46.53769 3.38088   -14.12926 1.000 30.56392 ?  220 ARG A N     1 
ATOM   750  C CA    . ARG A 1 102 ? -46.49446 2.19983   -14.98336 1.000 32.03892 ?  220 ARG A CA    1 
ATOM   751  C C     . ARG A 1 102 ? -47.78275 1.39573   -14.88309 1.000 33.38119 ?  220 ARG A C     1 
ATOM   752  O O     . ARG A 1 102 ? -48.29045 0.90806   -15.90415 1.000 33.39529 ?  220 ARG A O     1 
ATOM   753  C CB    . ARG A 1 102 ? -45.28963 1.33391   -14.61301 1.000 31.81478 ?  220 ARG A CB    1 
ATOM   754  C CG    . ARG A 1 102 ? -45.23389 0.02085   -15.38851 1.000 36.01295 ?  220 ARG A CG    1 
ATOM   755  C CD    . ARG A 1 102 ? -43.95920 -0.72336  -15.06105 1.000 42.61895 ?  220 ARG A CD    1 
ATOM   756  N NE    . ARG A 1 102 ? -44.18629 -2.15585  -14.90355 1.000 50.82864 ?  220 ARG A NE    1 
ATOM   757  C CZ    . ARG A 1 102 ? -43.93049 -3.04687  -15.84847 1.000 53.34155 ?  220 ARG A CZ    1 
ATOM   758  N NH1   . ARG A 1 102 ? -43.45507 -2.68181  -17.03205 1.000 59.71945 ?  220 ARG A NH1   1 
ATOM   759  N NH2   . ARG A 1 102 ? -44.16064 -4.33397  -15.60363 1.000 53.62751 ?  220 ARG A NH2   1 
ATOM   760  N N     . GLU A 1 103 ? -48.32050 1.22718   -13.66359 1.000 31.38702 ?  221 GLU A N     1 
ATOM   761  C CA    . GLU A 1 103 ? -49.64122 0.60932   -13.50440 1.000 32.65964 ?  221 GLU A CA    1 
ATOM   762  C C     . GLU A 1 103 ? -50.69183 1.31362   -14.34424 1.000 34.21191 ?  221 GLU A C     1 
ATOM   763  O O     . GLU A 1 103 ? -51.54130 0.67107   -14.98063 1.000 34.21529 ?  221 GLU A O     1 
ATOM   764  C CB    . GLU A 1 103 ? -50.10787 0.64786   -12.04938 1.000 34.34220 ?  221 GLU A CB    1 
ATOM   765  C CG    . GLU A 1 103 ? -51.17090 -0.36994  -11.75579 1.000 40.13847 ?  221 GLU A CG    1 
ATOM   766  C CD    . GLU A 1 103 ? -51.59236 -0.35593  -10.30822 1.000 44.36617 ?  221 GLU A CD    1 
ATOM   767  O OE1   . GLU A 1 103 ? -51.89226 -1.44465  -9.75924  1.000 51.85676 ?  221 GLU A OE1   1 
ATOM   768  O OE2   . GLU A 1 103 ? -51.61279 0.74733   -9.71820  1.000 44.19794 -1 221 GLU A OE2   1 
ATOM   769  N N     . LEU A 1 104 ? -50.66416 2.64536   -14.32864 1.000 31.48065 ?  222 LEU A N     1 
ATOM   770  C CA    . LEU A 1 104 ? -51.60696 3.41928   -15.11637 1.000 34.35979 ?  222 LEU A CA    1 
ATOM   771  C C     . LEU A 1 104 ? -51.37456 3.21142   -16.60887 1.000 35.03958 ?  222 LEU A C     1 
ATOM   772  O O     . LEU A 1 104 ? -52.33634 3.10688   -17.37589 1.000 37.68342 ?  222 LEU A O     1 
ATOM   773  C CB    . LEU A 1 104 ? -51.48991 4.90026   -14.73286 1.000 33.35600 ?  222 LEU A CB    1 
ATOM   774  C CG    . LEU A 1 104 ? -52.65197 5.84947   -15.01910 1.000 38.91003 ?  222 LEU A CG    1 
ATOM   775  C CD1   . LEU A 1 104 ? -53.97351 5.30439   -14.48474 1.000 35.62358 ?  222 LEU A CD1   1 
ATOM   776  C CD2   . LEU A 1 104 ? -52.30605 7.19319   -14.38472 1.000 36.53412 ?  222 LEU A CD2   1 
ATOM   777  N N     . GLN A 1 105 ? -50.11034 3.14756   -17.04628 1.000 32.85651 ?  223 GLN A N     1 
ATOM   778  C CA    . GLN A 1 105 ? -49.85057 2.82484   -18.44728 1.000 36.76374 ?  223 GLN A CA    1 
ATOM   779  C C     . GLN A 1 105 ? -50.48068 1.48617   -18.80845 1.000 40.65556 ?  223 GLN A C     1 
ATOM   780  O O     . GLN A 1 105 ? -51.01583 1.30903   -19.91270 1.000 40.06928 ?  223 GLN A O     1 
ATOM   781  C CB    . GLN A 1 105 ? -48.35328 2.72763   -18.73742 1.000 38.85321 ?  223 GLN A CB    1 
ATOM   782  C CG    . GLN A 1 105 ? -47.54376 4.00776   -18.80736 1.000 36.91518 ?  223 GLN A CG    1 
ATOM   783  C CD    . GLN A 1 105 ? -46.06559 3.68397   -19.04945 1.000 40.95531 ?  223 GLN A CD    1 
ATOM   784  O OE1   . GLN A 1 105 ? -45.43980 2.97768   -18.25399 1.000 38.88668 ?  223 GLN A OE1   1 
ATOM   785  N NE2   . GLN A 1 105 ? -45.47928 4.28403   -20.09355 1.000 43.29557 ?  223 GLN A NE2   1 
ATOM   786  N N     . LYS A 1 106 ? -50.41015 0.52557   -17.88779 1.000 36.70769 ?  224 LYS A N     1 
ATOM   787  C CA    . LYS A 1 106 ? -50.86181 -0.82768  -18.19499 1.000 37.64814 ?  224 LYS A CA    1 
ATOM   788  C C     . LYS A 1 106 ? -52.37760 -0.90715  -18.22139 1.000 39.40343 ?  224 LYS A C     1 
ATOM   789  O O     . LYS A 1 106 ? -52.95460 -1.50773  -19.13284 1.000 39.06208 ?  224 LYS A O     1 
ATOM   790  C CB    . LYS A 1 106 ? -50.29395 -1.80074  -17.17242 1.000 40.07579 ?  224 LYS A CB    1 
ATOM   791  C CG    . LYS A 1 106 ? -48.88833 -2.28403  -17.50931 1.000 46.70440 ?  224 LYS A CG    1 
ATOM   792  C CD    . LYS A 1 106 ? -48.11144 -2.60044  -16.24199 1.000 50.35482 ?  224 LYS A CD    1 
ATOM   793  C CE    . LYS A 1 106 ? -47.34275 -3.91405  -16.35158 1.000 58.68306 ?  224 LYS A CE    1 
ATOM   794  N NZ    . LYS A 1 106 ? -47.05762 -4.49638  -14.99713 1.000 60.16743 ?  224 LYS A NZ    1 
ATOM   795  N N     . LEU A 1 107 ? -53.04472 -0.29176  -17.24159 1.000 35.71012 ?  225 LEU A N     1 
ATOM   796  C CA    . LEU A 1 107 ? -54.49567 -0.38925  -17.11796 1.000 34.61735 ?  225 LEU A CA    1 
ATOM   797  C C     . LEU A 1 107 ? -55.25169 0.71802   -17.84412 1.000 37.00999 ?  225 LEU A C     1 
ATOM   798  O O     . LEU A 1 107 ? -56.47950 0.62211   -17.94695 1.000 36.13107 ?  225 LEU A O     1 
ATOM   799  C CB    . LEU A 1 107 ? -54.90757 -0.38444  -15.63281 1.000 36.46873 ?  225 LEU A CB    1 
ATOM   800  C CG    . LEU A 1 107 ? -54.23286 -1.41633  -14.72860 1.000 39.91982 ?  225 LEU A CG    1 
ATOM   801  C CD1   . LEU A 1 107 ? -54.77572 -1.32205  -13.31324 1.000 39.14027 ?  225 LEU A CD1   1 
ATOM   802  C CD2   . LEU A 1 107 ? -54.43310 -2.81329  -15.30035 1.000 41.03395 ?  225 LEU A CD2   1 
ATOM   803  N N     . SER A 1 108 ? -54.55120 1.75234   -18.32691 1.000 34.55401 ?  226 SER A N     1 
ATOM   804  C CA    . SER A 1 108 ? -55.08401 2.97000   -18.95541 1.000 36.00413 ?  226 SER A CA    1 
ATOM   805  C C     . SER A 1 108 ? -55.74881 3.93506   -17.96952 1.000 34.80794 ?  226 SER A C     1 
ATOM   806  O O     . SER A 1 108 ? -55.49931 5.14047   -18.04856 1.000 34.82562 ?  226 SER A O     1 
ATOM   807  C CB    . SER A 1 108 ? -56.06479 2.65738   -20.09281 1.000 39.95173 ?  226 SER A CB    1 
ATOM   808  O OG    . SER A 1 108 ? -55.41187 1.94849   -21.12834 1.000 46.58370 ?  226 SER A OG    1 
ATOM   809  N N     . LYS A 1 109 ? -56.61479 3.43964   -17.09014 1.000 34.06314 ?  227 LYS A N     1 
ATOM   810  C CA    . LYS A 1 109 ? -57.22224 4.24678   -16.03273 1.000 34.43816 ?  227 LYS A CA    1 
ATOM   811  C C     . LYS A 1 109 ? -57.67778 3.30091   -14.92694 1.000 38.83563 ?  227 LYS A C     1 
ATOM   812  O O     . LYS A 1 109 ? -57.83802 2.09573   -15.15226 1.000 36.94664 ?  227 LYS A O     1 
ATOM   813  C CB    . LYS A 1 109 ? -58.37068 5.11562   -16.57709 1.000 36.94105 ?  227 LYS A CB    1 
ATOM   814  C CG    . LYS A 1 109 ? -59.52949 4.35982   -17.20500 1.000 37.75530 ?  227 LYS A CG    1 
ATOM   815  C CD    . LYS A 1 109 ? -60.42918 5.32749   -18.00731 1.000 38.14925 ?  227 LYS A CD    1 
ATOM   816  C CE    . LYS A 1 109 ? -61.62242 4.59626   -18.61030 1.000 47.66018 ?  227 LYS A CE    1 
ATOM   817  N NZ    . LYS A 1 109 ? -62.67215 4.28290   -17.57857 1.000 51.89964 ?  227 LYS A NZ    1 
ATOM   818  N N     . PHE A 1 110 ? -57.81895 3.84476   -13.71377 1.000 34.75601 ?  228 PHE A N     1 
ATOM   819  C CA    . PHE A 1 110 ? -58.16761 3.07734   -12.51903 1.000 33.86364 ?  228 PHE A CA    1 
ATOM   820  C C     . PHE A 1 110 ? -59.66228 3.17260   -12.23078 1.000 39.14013 ?  228 PHE A C     1 
ATOM   821  O O     . PHE A 1 110 ? -60.29514 4.19352   -12.50030 1.000 34.85135 ?  228 PHE A O     1 
ATOM   822  C CB    . PHE A 1 110 ? -57.40443 3.59183   -11.29105 1.000 33.91106 ?  228 PHE A CB    1 
ATOM   823  C CG    . PHE A 1 110 ? -55.89467 3.42651   -11.37746 1.000 34.85683 ?  228 PHE A CG    1 
ATOM   824  C CD1   . PHE A 1 110 ? -55.31757 2.50633   -12.24879 1.000 36.25094 ?  228 PHE A CD1   1 
ATOM   825  C CD2   . PHE A 1 110 ? -55.05926 4.19726   -10.58425 1.000 33.69821 ?  228 PHE A CD2   1 
ATOM   826  C CE1   . PHE A 1 110 ? -53.91705 2.35862   -12.31940 1.000 36.56800 ?  228 PHE A CE1   1 
ATOM   827  C CE2   . PHE A 1 110 ? -53.66057 4.05587   -10.64390 1.000 33.62730 ?  228 PHE A CE2   1 
ATOM   828  C CZ    . PHE A 1 110 ? -53.09208 3.13498   -11.51737 1.000 33.27628 ?  228 PHE A CZ    1 
ATOM   829  N N     . ASP A 1 111 ? -60.22693 2.10598   -11.66412 1.000 36.77156 ?  229 ASP A N     1 
ATOM   830  C CA    . ASP A 1 111 ? -61.61359 2.19401   -11.22307 1.000 40.25588 ?  229 ASP A CA    1 
ATOM   831  C C     . ASP A 1 111 ? -61.69481 3.00032   -9.92080  1.000 38.83324 ?  229 ASP A C     1 
ATOM   832  O O     . ASP A 1 111 ? -60.68104 3.40997   -9.34572  1.000 33.34518 ?  229 ASP A O     1 
ATOM   833  C CB    . ASP A 1 111 ? -62.22735 0.79377   -11.07705 1.000 40.41645 ?  229 ASP A CB    1 
ATOM   834  C CG    . ASP A 1 111 ? -61.53277 -0.06788  -10.03829 1.000 41.75001 ?  229 ASP A CG    1 
ATOM   835  O OD1   . ASP A 1 111 ? -61.09437 0.42416   -8.97529  1.000 40.97929 ?  229 ASP A OD1   1 
ATOM   836  O OD2   . ASP A 1 111 ? -61.42455 -1.28016  -10.28180 1.000 52.10891 -1 229 ASP A OD2   1 
ATOM   837  N N     . GLU A 1 112 ? -62.92586 3.25402   -9.46569  1.000 40.03784 ?  230 GLU A N     1 
ATOM   838  C CA    . GLU A 1 112 ? -63.10311 4.15877   -8.33400  1.000 36.16337 ?  230 GLU A CA    1 
ATOM   839  C C     . GLU A 1 112 ? -62.61339 3.54141   -7.03951  1.000 39.12782 ?  230 GLU A C     1 
ATOM   840  O O     . GLU A 1 112 ? -62.18367 4.26314   -6.13270  1.000 36.05745 ?  230 GLU A O     1 
ATOM   841  C CB    . GLU A 1 112 ? -64.56959 4.57039   -8.19123  1.000 39.96159 ?  230 GLU A CB    1 
ATOM   842  C CG    . GLU A 1 112 ? -65.14694 5.23536   -9.43376  1.000 38.54915 ?  230 GLU A CG    1 
ATOM   843  C CD    . GLU A 1 112 ? -66.45884 5.91810   -9.14157  1.000 45.14316 ?  230 GLU A CD    1 
ATOM   844  O OE1   . GLU A 1 112 ? -67.45958 5.20764   -8.89529  1.000 44.48751 ?  230 GLU A OE1   1 
ATOM   845  O OE2   . GLU A 1 112 ? -66.48143 7.17014   -9.16319  1.000 43.39344 -1 230 GLU A OE2   1 
ATOM   846  N N     . GLN A 1 113 ? -62.68945 2.21573   -6.92424  1.000 38.79166 ?  231 GLN A N     1 
ATOM   847  C CA    . GLN A 1 113 ? -62.23049 1.55980   -5.70987  1.000 37.50707 ?  231 GLN A CA    1 
ATOM   848  C C     . GLN A 1 113 ? -60.71323 1.69743   -5.57244  1.000 34.32925 ?  231 GLN A C     1 
ATOM   849  O O     . GLN A 1 113 ? -60.20021 2.04954   -4.50158  1.000 38.77825 ?  231 GLN A O     1 
ATOM   850  C CB    . GLN A 1 113 ? -62.62271 0.07299   -5.72236  1.000 42.84547 ?  231 GLN A CB    1 
ATOM   851  C CG    . GLN A 1 113 ? -64.12793 -0.31087  -5.74603  1.000 47.04970 ?  231 GLN A CG    1 
ATOM   852  C CD    . GLN A 1 113 ? -64.99557 0.47704   -6.74135  1.000 50.61845 ?  231 GLN A CD    1 
ATOM   853  O OE1   . GLN A 1 113 ? -64.84946 0.32080   -7.96351  1.000 51.26634 ?  231 GLN A OE1   1 
ATOM   854  N NE2   . GLN A 1 113 ? -65.95705 1.23873   -6.22860  1.000 47.48602 ?  231 GLN A NE2   1 
ATOM   855  N N     . ARG A 1 114 ? -59.97567 1.41784   -6.64976  1.000 36.55212 ?  232 ARG A N     1 
ATOM   856  C CA    . ARG A 1 114 ? -58.52121 1.55818   -6.60661  1.000 33.57150 ?  232 ARG A CA    1 
ATOM   857  C C     . ARG A 1 114 ? -58.12189 3.00873   -6.35566  1.000 33.98484 ?  232 ARG A C     1 
ATOM   858  O O     . ARG A 1 114 ? -57.23896 3.28586   -5.53643  1.000 31.65719 ?  232 ARG A O     1 
ATOM   859  C CB    . ARG A 1 114 ? -57.89967 1.05086   -7.91405  1.000 34.60077 ?  232 ARG A CB    1 
ATOM   860  C CG    . ARG A 1 114 ? -56.37262 0.94458   -7.85369  1.000 36.14735 ?  232 ARG A CG    1 
ATOM   861  C CD    . ARG A 1 114 ? -55.74254 0.57499   -9.20003  1.000 42.80850 ?  232 ARG A CD    1 
ATOM   862  N NE    . ARG A 1 114 ? -56.07924 -0.78872  -9.60790  1.000 48.30872 ?  232 ARG A NE    1 
ATOM   863  C CZ    . ARG A 1 114 ? -55.46869 -1.89041  -9.18449  1.000 50.20474 ?  232 ARG A CZ    1 
ATOM   864  N NH1   . ARG A 1 114 ? -54.49603 -1.84778  -8.29208  1.000 48.19649 ?  232 ARG A NH1   1 
ATOM   865  N NH2   . ARG A 1 114 ? -55.85644 -3.07017  -9.66068  1.000 54.25267 ?  232 ARG A NH2   1 
ATOM   866  N N     . THR A 1 115 ? -58.76570 3.94285   -7.06506  1.000 33.88413 ?  233 THR A N     1 
ATOM   867  C CA    . THR A 1 115 ? -58.43618 5.36256   -6.95474  1.000 33.33945 ?  233 THR A CA    1 
ATOM   868  C C     . THR A 1 115 ? -58.65706 5.85626   -5.53624  1.000 33.94186 ?  233 THR A C     1 
ATOM   869  O O     . THR A 1 115 ? -57.76536 6.45470   -4.93071  1.000 34.13270 ?  233 THR A O     1 
ATOM   870  C CB    . THR A 1 115 ? -59.29253 6.17419   -7.94706  1.000 34.24932 ?  233 THR A CB    1 
ATOM   871  O OG1   . THR A 1 115 ? -58.96975 5.79120   -9.27539  1.000 30.40732 ?  233 THR A OG1   1 
ATOM   872  C CG2   . THR A 1 115 ? -59.04032 7.67268   -7.81083  1.000 30.49471 ?  233 THR A CG2   1 
ATOM   873  N N     . ALA A 1 116 ? -59.83909 5.58311   -4.97437  1.000 31.39204 ?  234 ALA A N     1 
ATOM   874  C CA    . ALA A 1 116 ? -60.14711 6.05705   -3.62816  1.000 34.07617 ?  234 ALA A CA    1 
ATOM   875  C C     . ALA A 1 116 ? -59.23015 5.42073   -2.58969  1.000 33.01548 ?  234 ALA A C     1 
ATOM   876  O O     . ALA A 1 116 ? -58.84746 6.07223   -1.60412  1.000 32.25271 ?  234 ALA A O     1 
ATOM   877  C CB    . ALA A 1 116 ? -61.62180 5.77772   -3.31376  1.000 32.96327 ?  234 ALA A CB    1 
ATOM   878  N N     . THR A 1 117 ? -58.86006 4.15113   -2.79280  1.000 31.63220 ?  235 THR A N     1 
ATOM   879  C CA    . THR A 1 117 ? -57.91494 3.49971   -1.88546  1.000 34.48330 ?  235 THR A CA    1 
ATOM   880  C C     . THR A 1 117 ? -56.54472 4.16819   -1.95520  1.000 33.73696 ?  235 THR A C     1 
ATOM   881  O O     . THR A 1 117 ? -55.92367 4.44503   -0.92066  1.000 30.72560 ?  235 THR A O     1 
ATOM   882  C CB    . THR A 1 117 ? -57.80836 2.00173   -2.21651  1.000 37.91731 ?  235 THR A CB    1 
ATOM   883  O OG1   . THR A 1 117 ? -59.09703 1.36852   -2.05965  1.000 39.14859 ?  235 THR A OG1   1 
ATOM   884  C CG2   . THR A 1 117 ? -56.78950 1.29626   -1.29432  1.000 37.59479 ?  235 THR A CG2   1 
ATOM   885  N N     . TYR A 1 118 ? -56.04923 4.43337   -3.17154  1.000 31.24079 ?  236 TYR A N     1 
ATOM   886  C CA    . TYR A 1 118 ? -54.74563 5.09249   -3.29366  1.000 29.81522 ?  236 TYR A CA    1 
ATOM   887  C C     . TYR A 1 118 ? -54.77365 6.48826   -2.67230  1.000 31.83264 ?  236 TYR A C     1 
ATOM   888  O O     . TYR A 1 118 ? -53.80531 6.90770   -2.02598  1.000 31.50397 ?  236 TYR A O     1 
ATOM   889  C CB    . TYR A 1 118 ? -54.33124 5.19518   -4.76535  1.000 31.81800 ?  236 TYR A CB    1 
ATOM   890  C CG    . TYR A 1 118 ? -53.85809 3.89448   -5.39807  1.000 31.78081 ?  236 TYR A CG    1 
ATOM   891  C CD1   . TYR A 1 118 ? -53.65849 2.74441   -4.64432  1.000 37.31672 ?  236 TYR A CD1   1 
ATOM   892  C CD2   . TYR A 1 118 ? -53.60910 3.82906   -6.75609  1.000 34.82815 ?  236 TYR A CD2   1 
ATOM   893  C CE1   . TYR A 1 118 ? -53.21623 1.54830   -5.25961  1.000 36.56020 ?  236 TYR A CE1   1 
ATOM   894  C CE2   . TYR A 1 118 ? -53.17157 2.66304   -7.36809  1.000 34.66596 ?  236 TYR A CE2   1 
ATOM   895  C CZ    . TYR A 1 118 ? -52.98092 1.53103   -6.62591  1.000 37.86320 ?  236 TYR A CZ    1 
ATOM   896  O OH    . TYR A 1 118 ? -52.55620 0.39525   -7.28473  1.000 39.41019 ?  236 TYR A OH    1 
ATOM   897  N N     . ILE A 1 119 ? -55.85962 7.23895   -2.89593  1.000 30.66585 ?  237 ILE A N     1 
ATOM   898  C CA    . ILE A 1 119 ? -55.94341 8.60534   -2.36230  1.000 31.95065 ?  237 ILE A CA    1 
ATOM   899  C C     . ILE A 1 119 ? -55.95889 8.57807   -0.83699  1.000 31.53090 ?  237 ILE A C     1 
ATOM   900  O O     . ILE A 1 119 ? -55.35350 9.43994   -0.17686  1.000 30.53599 ?  237 ILE A O     1 
ATOM   901  C CB    . ILE A 1 119 ? -57.17414 9.34443   -2.93292  1.000 29.94359 ?  237 ILE A CB    1 
ATOM   902  C CG1   . ILE A 1 119 ? -57.03364 9.55756   -4.46176  1.000 29.96036 ?  237 ILE A CG1   1 
ATOM   903  C CG2   . ILE A 1 119 ? -57.34822 10.71796  -2.25691  1.000 34.39286 ?  237 ILE A CG2   1 
ATOM   904  C CD1   . ILE A 1 119 ? -55.80763 10.39671  -4.83444  1.000 33.11777 ?  237 ILE A CD1   1 
ATOM   905  N N     . THR A 1 120 ? -56.65558 7.58870   -0.25442  1.000 30.84180 ?  238 THR A N     1 
ATOM   906  C CA    . THR A 1 120 ? -56.65074 7.41716   1.19884   1.000 31.09477 ?  238 THR A CA    1 
ATOM   907  C C     . THR A 1 120 ? -55.23409 7.20144   1.72175   1.000 33.01575 ?  238 THR A C     1 
ATOM   908  O O     . THR A 1 120 ? -54.80761 7.85830   2.67946   1.000 33.08306 ?  238 THR A O     1 
ATOM   909  C CB    . THR A 1 120 ? -57.57779 6.25925   1.59676   1.000 35.74417 ?  238 THR A CB    1 
ATOM   910  O OG1   . THR A 1 120 ? -58.93175 6.61264   1.27690   1.000 34.81710 ?  238 THR A OG1   1 
ATOM   911  C CG2   . THR A 1 120 ? -57.49038 5.94374   3.10156   1.000 35.24123 ?  238 THR A CG2   1 
ATOM   912  N N     . GLU A 1 121 ? -54.47710 6.29740   1.09020   1.000 33.35936 ?  239 GLU A N     1 
ATOM   913  C CA    . GLU A 1 121 ? -53.11126 6.05817   1.53701   1.000 31.19807 ?  239 GLU A CA    1 
ATOM   914  C C     . GLU A 1 121 ? -52.27193 7.32071   1.45903   1.000 34.03327 ?  239 GLU A C     1 
ATOM   915  O O     . GLU A 1 121 ? -51.50095 7.62297   2.38321   1.000 33.43987 ?  239 GLU A O     1 
ATOM   916  C CB    . GLU A 1 121 ? -52.46155 4.94843   0.71574   1.000 33.13244 ?  239 GLU A CB    1 
ATOM   917  C CG    . GLU A 1 121 ? -53.22050 3.64142   0.80150   1.000 36.99139 ?  239 GLU A CG    1 
ATOM   918  C CD    . GLU A 1 121 ? -52.56380 2.50579   0.02329   1.000 42.14383 ?  239 GLU A CD    1 
ATOM   919  O OE1   . GLU A 1 121 ? -52.41265 1.43195   0.62798   1.000 56.10233 ?  239 GLU A OE1   1 
ATOM   920  O OE2   . GLU A 1 121 ? -52.21619 2.66511   -1.15989  1.000 50.43347 -1 239 GLU A OE2   1 
ATOM   921  N N     . LEU A 1 122 ? -52.37906 8.05104   0.34631   1.000 30.14263 ?  240 LEU A N     1 
ATOM   922  C CA    . LEU A 1 122 ? -51.57938 9.25701   0.17756   1.000 31.25162 ?  240 LEU A CA    1 
ATOM   923  C C     . LEU A 1 122 ? -52.01461 10.34518  1.14376   1.000 31.57633 ?  240 LEU A C     1 
ATOM   924  O O     . LEU A 1 122 ? -51.17361 11.07753  1.67460   1.000 30.96281 ?  240 LEU A O     1 
ATOM   925  C CB    . LEU A 1 122 ? -51.69126 9.76224   -1.25104  1.000 31.37621 ?  240 LEU A CB    1 
ATOM   926  C CG    . LEU A 1 122 ? -51.01133 8.84413   -2.23620  1.000 34.80623 ?  240 LEU A CG    1 
ATOM   927  C CD1   . LEU A 1 122 ? -51.56181 9.11871   -3.57317  1.000 35.50023 ?  240 LEU A CD1   1 
ATOM   928  C CD2   . LEU A 1 122 ? -49.50147 9.11830   -2.19981  1.000 40.74637 ?  240 LEU A CD2   1 
ATOM   929  N N     . ALA A 1 123 ? -53.31944 10.47975  1.37096   1.000 29.35340 ?  241 ALA A N     1 
ATOM   930  C CA    . ALA A 1 123 ? -53.77692 11.48643  2.32610   1.000 31.92270 ?  241 ALA A CA    1 
ATOM   931  C C     . ALA A 1 123 ? -53.24424 11.18087  3.72072   1.000 33.50534 ?  241 ALA A C     1 
ATOM   932  O O     . ALA A 1 123 ? -52.84888 12.09518  4.46020   1.000 31.21695 ?  241 ALA A O     1 
ATOM   933  C CB    . ALA A 1 123 ? -55.30220 11.55891  2.33922   1.000 33.85444 ?  241 ALA A CB    1 
ATOM   934  N N     . ASN A 1 124 ? -53.17843 9.89375   4.07941   1.000 31.84051 ?  242 ASN A N     1 
ATOM   935  C CA    . ASN A 1 124 ? -52.62101 9.53175   5.38080   1.000 34.14795 ?  242 ASN A CA    1 
ATOM   936  C C     . ASN A 1 124 ? -51.13430 9.85687   5.44398   1.000 34.50606 ?  242 ASN A C     1 
ATOM   937  O O     . ASN A 1 124 ? -50.65406 10.43499  6.42681   1.000 32.98704 ?  242 ASN A O     1 
ATOM   938  C CB    . ASN A 1 124 ? -52.86390 8.04807   5.66060   1.000 35.68954 ?  242 ASN A CB    1 
ATOM   939  C CG    . ASN A 1 124 ? -54.26884 7.78106   6.14567   1.000 39.69127 ?  242 ASN A CG    1 
ATOM   940  O OD1   . ASN A 1 124 ? -54.82064 8.54774   6.93804   1.000 43.57818 ?  242 ASN A OD1   1 
ATOM   941  N ND2   . ASN A 1 124 ? -54.84236 6.67114   5.70694   1.000 45.38006 ?  242 ASN A ND2   1 
ATOM   942  N N     . ALA A 1 125 ? -50.38555 9.49699   4.39463   1.000 31.31014 ?  243 ALA A N     1 
ATOM   943  C CA    . ALA A 1 125 ? -48.96374 9.82963   4.34235   1.000 32.35871 ?  243 ALA A CA    1 
ATOM   944  C C     . ALA A 1 125 ? -48.73143 11.33731  4.38792   1.000 32.31417 ?  243 ALA A C     1 
ATOM   945  O O     . ALA A 1 125 ? -47.79551 11.80632  5.03927   1.000 31.68088 ?  243 ALA A O     1 
ATOM   946  C CB    . ALA A 1 125 ? -48.33615 9.25192   3.07058   1.000 30.79056 ?  243 ALA A CB    1 
ATOM   947  N N     . LEU A 1 126 ? -49.54249 12.10999  3.65921   1.000 28.57084 ?  244 LEU A N     1 
ATOM   948  C CA    . LEU A 1 126 ? -49.33376 13.55213  3.63118   1.000 30.11201 ?  244 LEU A CA    1 
ATOM   949  C C     . LEU A 1 126 ? -49.70878 14.19084  4.96636   1.000 31.60422 ?  244 LEU A C     1 
ATOM   950  O O     . LEU A 1 126 ? -49.10976 15.19708  5.36467   1.000 33.14632 ?  244 LEU A O     1 
ATOM   951  C CB    . LEU A 1 126 ? -50.15919 14.16188  2.50467   1.000 31.21175 ?  244 LEU A CB    1 
ATOM   952  C CG    . LEU A 1 126 ? -49.66778 13.78662  1.10281   1.000 32.21993 ?  244 LEU A CG    1 
ATOM   953  C CD1   . LEU A 1 126 ? -50.62872 14.34848  0.07939   1.000 31.31638 ?  244 LEU A CD1   1 
ATOM   954  C CD2   . LEU A 1 126 ? -48.26438 14.33994  0.92945   1.000 34.19806 ?  244 LEU A CD2   1 
ATOM   955  N N     . SER A 1 127 ? -50.70796 13.63896  5.65067   1.000 34.43440 ?  245 SER A N     1 
ATOM   956  C CA    . SER A 1 127 ? -51.05812 14.14045  6.97887   1.000 34.11969 ?  245 SER A CA    1 
ATOM   957  C C     . SER A 1 127 ? -49.90469 13.94160  7.95024   1.000 35.81022 ?  245 SER A C     1 
ATOM   958  O O     . SER A 1 127 ? -49.57386 14.83848  8.74287   1.000 35.60367 ?  245 SER A O     1 
ATOM   959  C CB    . SER A 1 127 ? -52.31432 13.43530  7.47987   1.000 38.97685 ?  245 SER A CB    1 
ATOM   960  O OG    . SER A 1 127 ? -52.82766 14.13760  8.59870   1.000 48.94277 ?  245 SER A OG    1 
ATOM   961  N N     . TYR A 1 128 ? -49.27284 12.76998  7.89265   1.000 35.45456 ?  246 TYR A N     1 
ATOM   962  C CA    . TYR A 1 128 ? -48.08513 12.51663  8.69414   1.000 35.55369 ?  246 TYR A CA    1 
ATOM   963  C C     . TYR A 1 128 ? -46.97030 13.49233  8.33791   1.000 35.81463 ?  246 TYR A C     1 
ATOM   964  O O     . TYR A 1 128 ? -46.37398 14.12614  9.22132   1.000 35.35070 ?  246 TYR A O     1 
ATOM   965  C CB    . TYR A 1 128 ? -47.64372 11.05919  8.49172   1.000 36.59763 ?  246 TYR A CB    1 
ATOM   966  C CG    . TYR A 1 128 ? -46.28203 10.73873  9.08025   1.000 38.39614 ?  246 TYR A CG    1 
ATOM   967  C CD1   . TYR A 1 128 ? -46.11861 10.52341  10.44397  1.000 36.55934 ?  246 TYR A CD1   1 
ATOM   968  C CD2   . TYR A 1 128 ? -45.16653 10.64563  8.26505   1.000 38.47177 ?  246 TYR A CD2   1 
ATOM   969  C CE1   . TYR A 1 128 ? -44.87675 10.21942  10.97472  1.000 42.11972 ?  246 TYR A CE1   1 
ATOM   970  C CE2   . TYR A 1 128 ? -43.91925 10.35464  8.78299   1.000 39.61659 ?  246 TYR A CE2   1 
ATOM   971  C CZ    . TYR A 1 128 ? -43.78208 10.14800  10.13884  1.000 43.40696 ?  246 TYR A CZ    1 
ATOM   972  O OH    . TYR A 1 128 ? -42.54705 9.85543   10.63965  1.000 41.66868 ?  246 TYR A OH    1 
ATOM   973  N N     . CYS A 1 129 ? -46.68185 13.64214  7.03755   1.000 36.54513 ?  247 CYS A N     1 
ATOM   974  C CA    . CYS A 1 129 ? -45.68125 14.61496  6.60878   1.000 35.30582 ?  247 CYS A CA    1 
ATOM   975  C C     . CYS A 1 129 ? -45.96300 15.98843  7.20107   1.000 34.26032 ?  247 CYS A C     1 
ATOM   976  O O     . CYS A 1 129 ? -45.07831 16.61896  7.79216   1.000 34.61232 ?  247 CYS A O     1 
ATOM   977  C CB    . CYS A 1 129 ? -45.66738 14.71676  5.08662   1.000 34.31527 ?  247 CYS A CB    1 
ATOM   978  S SG    . CYS A 1 129 ? -44.77565 13.34465  4.30043   1.000 37.02932 ?  247 CYS A SG    1 
ATOM   979  N N     . HIS A 1 130 ? -47.20070 16.47670  7.02710   1.000 33.43544 ?  248 HIS A N     1 
ATOM   980  C CA    . HIS A 1 130 ? -47.53661 17.82387  7.48491   1.000 35.32699 ?  248 HIS A CA    1 
ATOM   981  C C     . HIS A 1 130 ? -47.34980 17.95689  8.98945   1.000 37.17607 ?  248 HIS A C     1 
ATOM   982  O O     . HIS A 1 130 ? -46.90903 19.00601  9.47650   1.000 39.95000 ?  248 HIS A O     1 
ATOM   983  C CB    . HIS A 1 130 ? -48.97423 18.18419  7.09034   1.000 33.47936 ?  248 HIS A CB    1 
ATOM   984  C CG    . HIS A 1 130 ? -49.15393 18.41933  5.62311   1.000 35.04666 ?  248 HIS A CG    1 
ATOM   985  N ND1   . HIS A 1 130 ? -50.35402 18.81603  5.07036   1.000 36.22789 ?  248 HIS A ND1   1 
ATOM   986  C CD2   . HIS A 1 130 ? -48.27821 18.32118  4.59381   1.000 34.92276 ?  248 HIS A CD2   1 
ATOM   987  C CE1   . HIS A 1 130 ? -50.21036 18.94042  3.76105   1.000 38.23137 ?  248 HIS A CE1   1 
ATOM   988  N NE2   . HIS A 1 130 ? -48.96253 18.63669  3.44542   1.000 32.39117 ?  248 HIS A NE2   1 
ATOM   989  N N     . SER A 1 131 ? -47.67980 16.90436  9.73726   1.000 35.05782 ?  249 SER A N     1 
ATOM   990  C CA    . SER A 1 131 ? -47.48028 16.91471  11.18382  1.000 36.71287 ?  249 SER A CA    1 
ATOM   991  C C     . SER A 1 131 ? -46.02120 17.11272  11.55113  1.000 43.21120 ?  249 SER A C     1 
ATOM   992  O O     . SER A 1 131 ? -45.72626 17.50194  12.68768  1.000 42.06200 ?  249 SER A O     1 
ATOM   993  C CB    . SER A 1 131 ? -47.99346 15.60893  11.79928  1.000 38.34275 ?  249 SER A CB    1 
ATOM   994  O OG    . SER A 1 131 ? -47.03067 14.56558  11.65996  1.000 40.86877 ?  249 SER A OG    1 
ATOM   995  N N     . LYS A 1 132 ? -45.10107 16.87134  10.61414  1.000 37.72051 ?  250 LYS A N     1 
ATOM   996  C CA    . LYS A 1 132 ? -43.68385 17.11587  10.84469  1.000 40.98832 ?  250 LYS A CA    1 
ATOM   997  C C     . LYS A 1 132 ? -43.18156 18.34184  10.09224  1.000 40.22595 ?  250 LYS A C     1 
ATOM   998  O O     . LYS A 1 132 ? -41.96994 18.50414  9.91720   1.000 39.13382 ?  250 LYS A O     1 
ATOM   999  C CB    . LYS A 1 132 ? -42.87408 15.87280  10.46929  1.000 38.58044 ?  250 LYS A CB    1 
ATOM   1000 C CG    . LYS A 1 132 ? -43.19804 14.69603  11.38347  1.000 46.99459 ?  250 LYS A CG    1 
ATOM   1001 C CD    . LYS A 1 132 ? -42.12982 13.62136  11.37370  1.000 52.06081 ?  250 LYS A CD    1 
ATOM   1002 C CE    . LYS A 1 132 ? -42.22024 12.79777  12.66139  1.000 57.12061 ?  250 LYS A CE    1 
ATOM   1003 N NZ    . LYS A 1 132 ? -40.86727 12.55687  13.26397  1.000 63.93306 ?  250 LYS A NZ    1 
ATOM   1004 N N     . ARG A 1 133 ? -44.09300 19.21631  9.65170   1.000 39.59138 ?  251 ARG A N     1 
ATOM   1005 C CA    . ARG A 1 133 ? -43.75722 20.38357  8.82945   1.000 39.20148 ?  251 ARG A CA    1 
ATOM   1006 C C     . ARG A 1 133 ? -43.00338 19.99795  7.54904   1.000 39.73863 ?  251 ARG A C     1 
ATOM   1007 O O     . ARG A 1 133 ? -42.18094 20.76509  7.03314   1.000 39.12985 ?  251 ARG A O     1 
ATOM   1008 C CB    . ARG A 1 133 ? -42.98958 21.45522  9.63103   1.000 44.57562 ?  251 ARG A CB    1 
ATOM   1009 C CG    . ARG A 1 133 ? -43.41997 21.56970  11.10975  1.000 46.63697 ?  251 ARG A CG    1 
ATOM   1010 C CD    . ARG A 1 133 ? -42.90170 22.85544  11.82132  1.000 56.97729 ?  251 ARG A CD    1 
ATOM   1011 N NE    . ARG A 1 133 ? -41.46485 22.86784  12.08020  1.000 61.70513 ?  251 ARG A NE    1 
ATOM   1012 C CZ    . ARG A 1 133 ? -40.92476 22.95115  13.29241  1.000 66.19461 ?  251 ARG A CZ    1 
ATOM   1013 N NH1   . ARG A 1 133 ? -41.67617 23.06714  14.37977  1.000 60.15745 ?  251 ARG A NH1   1 
ATOM   1014 N NH2   . ARG A 1 133 ? -39.59819 22.91688  13.41796  1.000 62.55250 ?  251 ARG A NH2   1 
ATOM   1015 N N     . VAL A 1 134 ? -43.30393 18.82509  7.00229   1.000 34.22613 ?  252 VAL A N     1 
ATOM   1016 C CA    . VAL A 1 134 ? -42.77416 18.39132  5.71127   1.000 36.80103 ?  252 VAL A CA    1 
ATOM   1017 C C     . VAL A 1 134 ? -43.86904 18.61074  4.67497   1.000 37.72461 ?  252 VAL A C     1 
ATOM   1018 O O     . VAL A 1 134 ? -44.92692 17.97700  4.75345   1.000 33.97399 ?  252 VAL A O     1 
ATOM   1019 C CB    . VAL A 1 134 ? -42.35014 16.91390  5.74713   1.000 36.53474 ?  252 VAL A CB    1 
ATOM   1020 C CG1   . VAL A 1 134 ? -41.87751 16.46354  4.36932   1.000 38.40291 ?  252 VAL A CG1   1 
ATOM   1021 C CG2   . VAL A 1 134 ? -41.27407 16.69352  6.77179   1.000 37.89808 ?  252 VAL A CG2   1 
ATOM   1022 N N     . ILE A 1 135 ? -43.63849 19.49781  3.70177   1.000 36.83575 ?  253 ILE A N     1 
ATOM   1023 C CA    . ILE A 1 135 ? -44.67822 19.83708  2.73206   1.000 37.37845 ?  253 ILE A CA    1 
ATOM   1024 C C     . ILE A 1 135 ? -44.13657 19.74685  1.30788   1.000 36.12553 ?  253 ILE A C     1 
ATOM   1025 O O     . ILE A 1 135 ? -42.93168 19.64746  1.06509   1.000 38.79320 ?  253 ILE A O     1 
ATOM   1026 C CB    . ILE A 1 135 ? -45.28706 21.23875  2.96554   1.000 41.45331 ?  253 ILE A CB    1 
ATOM   1027 C CG1   . ILE A 1 135 ? -44.29894 22.34545  2.57204   1.000 40.90228 ?  253 ILE A CG1   1 
ATOM   1028 C CG2   . ILE A 1 135 ? -45.70760 21.39175  4.43416   1.000 39.74972 ?  253 ILE A CG2   1 
ATOM   1029 C CD1   . ILE A 1 135 ? -44.91071 23.75147  2.53361   1.000 40.50922 ?  253 ILE A CD1   1 
ATOM   1030 N N     . HIS A 1 136 ? -45.06858 19.80037  0.35862   1.000 37.58718 ?  254 HIS A N     1 
ATOM   1031 C CA    . HIS A 1 136 ? -44.77338 19.82069  -1.07164  1.000 39.18723 ?  254 HIS A CA    1 
ATOM   1032 C C     . HIS A 1 136 ? -43.95512 18.60103  -1.48400  1.000 38.85530 ?  254 HIS A C     1 
ATOM   1033 O O     . HIS A 1 136 ? -42.83582 18.70637  -1.97876  1.000 40.13741 ?  254 HIS A O     1 
ATOM   1034 C CB    . HIS A 1 136 ? -44.07100 21.11541  -1.47994  1.000 40.41961 ?  254 HIS A CB    1 
ATOM   1035 C CG    . HIS A 1 136 ? -43.90599 21.26604  -2.95957  1.000 45.56094 ?  254 HIS A CG    1 
ATOM   1036 N ND1   . HIS A 1 136 ? -44.88528 20.90187  -3.86048  1.000 44.17996 ?  254 HIS A ND1   1 
ATOM   1037 C CD2   . HIS A 1 136 ? -42.88792 21.77187  -3.69368  1.000 49.79056 ?  254 HIS A CD2   1 
ATOM   1038 C CE1   . HIS A 1 136 ? -44.47079 21.16553  -5.08739  1.000 46.89290 ?  254 HIS A CE1   1 
ATOM   1039 N NE2   . HIS A 1 136 ? -43.26236 21.69500  -5.01322  1.000 55.72279 ?  254 HIS A NE2   1 
ATOM   1040 N N     . ARG A 1 137 ? -44.53829 17.43098  -1.28531  1.000 33.66089 ?  255 ARG A N     1 
ATOM   1041 C CA    . ARG A 1 137 ? -43.95883 16.24214  -1.89431  1.000 36.01945 ?  255 ARG A CA    1 
ATOM   1042 C C     . ARG A 1 137 ? -44.44985 16.17087  -3.33362  1.000 36.10532 ?  255 ARG A C     1 
ATOM   1043 O O     . ARG A 1 137 ? -45.61758 16.44753  -3.61217  1.000 38.28948 ?  255 ARG A O     1 
ATOM   1044 C CB    . ARG A 1 137 ? -44.34952 14.98731  -1.11901  1.000 36.11987 ?  255 ARG A CB    1 
ATOM   1045 C CG    . ARG A 1 137 ? -44.05593 15.05932  0.38680   1.000 37.88368 ?  255 ARG A CG    1 
ATOM   1046 C CD    . ARG A 1 137 ? -42.58626 15.33583  0.66570   1.000 43.13607 ?  255 ARG A CD    1 
ATOM   1047 N NE    . ARG A 1 137 ? -41.80114 14.11664  0.49238   1.000 48.10946 ?  255 ARG A NE    1 
ATOM   1048 C CZ    . ARG A 1 137 ? -40.61645 13.89002  1.04460   1.000 49.31944 ?  255 ARG A CZ    1 
ATOM   1049 N NH1   . ARG A 1 137 ? -40.06880 14.75526  1.88316   1.000 48.47673 ?  255 ARG A NH1   1 
ATOM   1050 N NH2   . ARG A 1 137 ? -39.97091 12.75817  0.75790   1.000 45.01671 ?  255 ARG A NH2   1 
ATOM   1051 N N     . ASP A 1 138 ? -43.55108 15.83211  -4.25294  1.000 35.44902 ?  256 ASP A N     1 
ATOM   1052 C CA    . ASP A 1 138 ? -43.90513 15.74808  -5.67111  1.000 32.99255 ?  256 ASP A CA    1 
ATOM   1053 C C     . ASP A 1 138 ? -44.52704 14.38023  -5.88655  1.000 33.13324 ?  256 ASP A C     1 
ATOM   1054 O O     . ASP A 1 138 ? -43.81640 13.39256  -6.08403  1.000 35.67921 ?  256 ASP A O     1 
ATOM   1055 C CB    . ASP A 1 138 ? -42.67234 15.96899  -6.54048  1.000 35.62782 ?  256 ASP A CB    1 
ATOM   1056 C CG    . ASP A 1 138 ? -42.99071 16.01359  -8.02735  1.000 40.63731 ?  256 ASP A CG    1 
ATOM   1057 O OD1   . ASP A 1 138 ? -44.17792 15.94616  -8.41649  1.000 38.48599 ?  256 ASP A OD1   1 
ATOM   1058 O OD2   . ASP A 1 138 ? -42.03360 16.15003  -8.80778  1.000 40.39062 -1 256 ASP A OD2   1 
ATOM   1059 N N     . ILE A 1 139 ? -45.86233 14.31286  -5.82602  1.000 30.89424 ?  257 ILE A N     1 
ATOM   1060 C CA    . ILE A 1 139 ? -46.54706 13.02296  -5.79933  1.000 28.71017 ?  257 ILE A CA    1 
ATOM   1061 C C     . ILE A 1 139 ? -47.09763 12.68457  -7.17573  1.000 28.28508 ?  257 ILE A C     1 
ATOM   1062 O O     . ILE A 1 139 ? -48.11115 11.97864  -7.28777  1.000 29.62584 ?  257 ILE A O     1 
ATOM   1063 C CB    . ILE A 1 139 ? -47.66677 12.99746  -4.73737  1.000 32.84041 ?  257 ILE A CB    1 
ATOM   1064 C CG1   . ILE A 1 139 ? -48.67642 14.12585  -4.98582  1.000 30.51836 ?  257 ILE A CG1   1 
ATOM   1065 C CG2   . ILE A 1 139 ? -47.06660 13.06580  -3.31434  1.000 29.69675 ?  257 ILE A CG2   1 
ATOM   1066 C CD1   . ILE A 1 139 ? -49.92665 14.00674  -4.11968  1.000 33.45436 ?  257 ILE A CD1   1 
ATOM   1067 N N     . LYS A 1 140 ? -46.44687 13.19036  -8.23463  1.000 27.17094 ?  258 LYS A N     1 
ATOM   1068 C CA    . LYS A 1 140 ? -46.76529 12.68302  -9.57312  1.000 30.13712 ?  258 LYS A CA    1 
ATOM   1069 C C     . LYS A 1 140 ? -46.59157 11.16384  -9.56126  1.000 25.94126 ?  258 LYS A C     1 
ATOM   1070 O O     . LYS A 1 140 ? -45.74507 10.65010  -8.80246  1.000 27.90011 ?  258 LYS A O     1 
ATOM   1071 C CB    . LYS A 1 140 ? -45.85996 13.32971  -10.62435 1.000 29.83968 ?  258 LYS A CB    1 
ATOM   1072 C CG    . LYS A 1 140 ? -44.37532 12.98110  -10.46853 1.000 30.98269 ?  258 LYS A CG    1 
ATOM   1073 C CD    . LYS A 1 140 ? -43.52806 13.72564  -11.51892 1.000 34.36432 ?  258 LYS A CD    1 
ATOM   1074 C CE    . LYS A 1 140 ? -42.02400 13.53305  -11.24803 1.000 39.17588 ?  258 LYS A CE    1 
ATOM   1075 N NZ    . LYS A 1 140 ? -41.15323 14.13556  -12.31252 1.000 35.89010 ?  258 LYS A NZ    1 
ATOM   1076 N N     . PRO A 1 141 ? -47.37164 10.41979  -10.36837 1.000 29.28900 ?  259 PRO A N     1 
ATOM   1077 C CA    . PRO A 1 141 ? -47.40056 8.94376   -10.24373 1.000 29.39657 ?  259 PRO A CA    1 
ATOM   1078 C C     . PRO A 1 141 ? -46.07725 8.28110   -10.51786 1.000 28.09602 ?  259 PRO A C     1 
ATOM   1079 O O     . PRO A 1 141 ? -45.86003 7.15654   -10.03884 1.000 30.13714 ?  259 PRO A O     1 
ATOM   1080 C CB    . PRO A 1 141 ? -48.42383 8.49505   -11.29970 1.000 30.68174 ?  259 PRO A CB    1 
ATOM   1081 C CG    . PRO A 1 141 ? -48.95373 9.70359   -11.92712 1.000 32.18503 ?  259 PRO A CG    1 
ATOM   1082 C CD    . PRO A 1 141 ? -48.23427 10.91746  -11.45516 1.000 31.58596 ?  259 PRO A CD    1 
ATOM   1083 N N     . GLU A 1 142 ? -45.20662 8.91878   -11.30694 1.000 29.83563 ?  260 GLU A N     1 
ATOM   1084 C CA    . GLU A 1 142 ? -43.83541 8.42608   -11.47490 1.000 27.80654 ?  260 GLU A CA    1 
ATOM   1085 C C     . GLU A 1 142 ? -43.05969 8.39038   -10.16536 1.000 27.37634 ?  260 GLU A C     1 
ATOM   1086 O O     . GLU A 1 142 ? -42.05489 7.67278   -10.07380 1.000 32.84525 ?  260 GLU A O     1 
ATOM   1087 C CB    . GLU A 1 142 ? -43.04446 9.30718   -12.45256 1.000 33.52495 ?  260 GLU A CB    1 
ATOM   1088 C CG    . GLU A 1 142 ? -43.61248 9.42235   -13.83760 1.000 37.70781 ?  260 GLU A CG    1 
ATOM   1089 C CD    . GLU A 1 142 ? -44.52065 10.64406  -14.00606 1.000 37.54689 ?  260 GLU A CD    1 
ATOM   1090 O OE1   . GLU A 1 142 ? -45.46476 10.81748  -13.20825 1.000 32.12901 ?  260 GLU A OE1   1 
ATOM   1091 O OE2   . GLU A 1 142 ? -44.29078 11.41623  -14.96315 1.000 39.46719 -1 260 GLU A OE2   1 
ATOM   1092 N N     . ASN A 1 143 ? -43.45719 9.17086   -9.16560  1.000 28.70880 ?  261 ASN A N     1 
ATOM   1093 C CA    . ASN A 1 143 ? -42.77763 9.15740   -7.86978  1.000 27.34186 ?  261 ASN A CA    1 
ATOM   1094 C C     . ASN A 1 143 ? -43.53242 8.34920   -6.82142  1.000 30.41820 ?  261 ASN A C     1 
ATOM   1095 O O     . ASN A 1 143 ? -43.18938 8.41600   -5.63544  1.000 30.57146 ?  261 ASN A O     1 
ATOM   1096 C CB    . ASN A 1 143 ? -42.56850 10.58148  -7.32290  1.000 27.50276 ?  261 ASN A CB    1 
ATOM   1097 C CG    . ASN A 1 143 ? -41.46235 11.32933  -8.02890  1.000 33.67945 ?  261 ASN A CG    1 
ATOM   1098 O OD1   . ASN A 1 143 ? -40.57207 10.72567  -8.64918  1.000 31.73965 ?  261 ASN A OD1   1 
ATOM   1099 N ND2   . ASN A 1 143 ? -41.46575 12.65733  -7.87690  1.000 30.68497 ?  261 ASN A ND2   1 
ATOM   1100 N N     . LEU A 1 144 ? -44.54945 7.60321   -7.21888  1.000 26.72765 ?  262 LEU A N     1 
ATOM   1101 C CA    . LEU A 1 144 ? -45.33916 6.79214   -6.29307  1.000 29.31815 ?  262 LEU A CA    1 
ATOM   1102 C C     . LEU A 1 144 ? -45.08597 5.33793   -6.64752  1.000 30.04749 ?  262 LEU A C     1 
ATOM   1103 O O     . LEU A 1 144 ? -45.27755 4.94848   -7.80058  1.000 29.49030 ?  262 LEU A O     1 
ATOM   1104 C CB    . LEU A 1 144 ? -46.82471 7.10468   -6.42101  1.000 30.19952 ?  262 LEU A CB    1 
ATOM   1105 C CG    . LEU A 1 144 ? -47.21873 8.57619   -6.21546  1.000 28.37653 ?  262 LEU A CG    1 
ATOM   1106 C CD1   . LEU A 1 144 ? -48.73046 8.67872   -6.40236  1.000 27.21285 ?  262 LEU A CD1   1 
ATOM   1107 C CD2   . LEU A 1 144 ? -46.78781 9.08379   -4.85453  1.000 26.52607 ?  262 LEU A CD2   1 
ATOM   1108 N N     . LEU A 1 145 ? -44.64195 4.54992   -5.68026  1.000 27.51826 ?  263 LEU A N     1 
ATOM   1109 C CA    . LEU A 1 145 ? -44.28149 3.16685   -5.95839  1.000 30.48911 ?  263 LEU A CA    1 
ATOM   1110 C C     . LEU A 1 145 ? -45.23799 2.21813   -5.25106  1.000 32.91923 ?  263 LEU A C     1 
ATOM   1111 O O     . LEU A 1 145 ? -45.95435 2.58780   -4.31248  1.000 32.33217 ?  263 LEU A O     1 
ATOM   1112 C CB    . LEU A 1 145 ? -42.85346 2.87705   -5.50254  1.000 30.79563 ?  263 LEU A CB    1 
ATOM   1113 C CG    . LEU A 1 145 ? -41.81139 3.89256   -5.95578  1.000 32.83764 ?  263 LEU A CG    1 
ATOM   1114 C CD1   . LEU A 1 145 ? -40.46815 3.49132   -5.41880  1.000 32.56527 ?  263 LEU A CD1   1 
ATOM   1115 C CD2   . LEU A 1 145 ? -41.78561 4.03744   -7.48941  1.000 30.82427 ?  263 LEU A CD2   1 
ATOM   1116 N N     . LEU A 1 146 ? -45.21758 0.97373   -5.69710  1.000 32.31897 ?  264 LEU A N     1 
ATOM   1117 C CA    . LEU A 1 146 ? -46.09207 -0.06588  -5.17199  1.000 35.81504 ?  264 LEU A CA    1 
ATOM   1118 C C     . LEU A 1 146 ? -45.24820 -1.07778  -4.41075  1.000 34.11682 ?  264 LEU A C     1 
ATOM   1119 O O     . LEU A 1 146 ? -44.35335 -1.70389  -4.99569  1.000 31.94780 ?  264 LEU A O     1 
ATOM   1120 C CB    . LEU A 1 146 ? -46.86707 -0.72728  -6.31274  1.000 36.18935 ?  264 LEU A CB    1 
ATOM   1121 C CG    . LEU A 1 146 ? -47.79888 0.25089   -7.04153  1.000 36.55401 ?  264 LEU A CG    1 
ATOM   1122 C CD1   . LEU A 1 146 ? -48.34103 -0.34232  -8.33164  1.000 38.80359 ?  264 LEU A CD1   1 
ATOM   1123 C CD2   . LEU A 1 146 ? -48.94887 0.63198   -6.11185  1.000 38.82370 ?  264 LEU A CD2   1 
ATOM   1124 N N     . GLY A 1 147 ? -45.47955 -1.17815  -3.10192  1.000 35.01911 ?  265 GLY A N     1 
ATOM   1125 C CA    . GLY A 1 147 ? -44.82735 -2.18029  -2.28385  1.000 37.86802 ?  265 GLY A CA    1 
ATOM   1126 C C     . GLY A 1 147 ? -45.35581 -3.57047  -2.59076  1.000 40.10250 ?  265 GLY A C     1 
ATOM   1127 O O     . GLY A 1 147 ? -46.24264 -3.76802  -3.41980  1.000 41.14706 ?  265 GLY A O     1 
ATOM   1128 N N     . SER A 1 148 ? -44.78191 -4.56533  -1.90470  1.000 46.92739 ?  266 SER A N     1 
ATOM   1129 C CA    . SER A 1 148 ? -45.10946 -5.95510  -2.22753  1.000 47.34320 ?  266 SER A CA    1 
ATOM   1130 C C     . SER A 1 148 ? -46.58515 -6.26492  -1.99577  1.000 50.70168 ?  266 SER A C     1 
ATOM   1131 O O     . SER A 1 148 ? -47.14851 -7.14886  -2.65768  1.000 52.12416 ?  266 SER A O     1 
ATOM   1132 C CB    . SER A 1 148 ? -44.22961 -6.90350  -1.41511  1.000 50.03716 ?  266 SER A CB    1 
ATOM   1133 O OG    . SER A 1 148 ? -44.62078 -6.89137  -0.05467  1.000 57.11851 ?  266 SER A OG    1 
ATOM   1134 N N     . ALA A 1 149 ? -47.22474 -5.55482  -1.07289  1.000 48.26256 ?  267 ALA A N     1 
ATOM   1135 C CA    . ALA A 1 149 ? -48.64921 -5.70810  -0.82764  1.000 50.90139 ?  267 ALA A CA    1 
ATOM   1136 C C     . ALA A 1 149 ? -49.49629 -4.78875  -1.69210  1.000 47.64868 ?  267 ALA A C     1 
ATOM   1137 O O     . ALA A 1 149 ? -50.70208 -4.67155  -1.45348  1.000 51.50241 ?  267 ALA A O     1 
ATOM   1138 C CB    . ALA A 1 149 ? -48.95863 -5.45629  0.64863   1.000 50.34659 ?  267 ALA A CB    1 
ATOM   1139 N N     . GLY A 1 150 ? -48.90723 -4.15320  -2.70251  1.000 43.91174 ?  268 GLY A N     1 
ATOM   1140 C CA    . GLY A 1 150 ? -49.66930 -3.22137  -3.50848  1.000 42.82889 ?  268 GLY A CA    1 
ATOM   1141 C C     . GLY A 1 150 ? -49.96239 -1.91020  -2.82079  1.000 41.65806 ?  268 GLY A C     1 
ATOM   1142 O O     . GLY A 1 150 ? -50.79268 -1.14031  -3.30944  1.000 43.62630 ?  268 GLY A O     1 
ATOM   1143 N N     . GLU A 1 151 ? -49.31918 -1.65053  -1.68810  1.000 43.03684 ?  269 GLU A N     1 
ATOM   1144 C CA    . GLU A 1 151 ? -49.49480 -0.40492  -0.95938  1.000 44.75460 ?  269 GLU A CA    1 
ATOM   1145 C C     . GLU A 1 151 ? -48.63043 0.69687   -1.57030  1.000 38.74628 ?  269 GLU A C     1 
ATOM   1146 O O     . GLU A 1 151 ? -47.49524 0.45997   -1.99932  1.000 38.45522 ?  269 GLU A O     1 
ATOM   1147 C CB    . GLU A 1 151 ? -49.14382 -0.61283  0.51360   1.000 43.13717 ?  269 GLU A CB    1 
ATOM   1148 C CG    . GLU A 1 151 ? -47.66689 -0.53893  0.82104   1.000 43.51954 ?  269 GLU A CG    1 
ATOM   1149 C CD    . GLU A 1 151 ? -47.01074 -1.90561  0.86825   1.000 50.25404 ?  269 GLU A CD    1 
ATOM   1150 O OE1   . GLU A 1 151 ? -47.49506 -2.82362  0.16195   1.000 51.50549 ?  269 GLU A OE1   1 
ATOM   1151 O OE2   . GLU A 1 151 ? -46.00017 -2.06179  1.59136   1.000 52.68042 -1 269 GLU A OE2   1 
ATOM   1152 N N     . LEU A 1 152 ? -49.18651 1.90287   -1.60768  1.000 37.81842 ?  270 LEU A N     1 
ATOM   1153 C CA    . LEU A 1 152 ? -48.52936 3.04815   -2.22277  1.000 38.62877 ?  270 LEU A CA    1 
ATOM   1154 C C     . LEU A 1 152 ? -47.38907 3.55239   -1.34863  1.000 36.84067 ?  270 LEU A C     1 
ATOM   1155 O O     . LEU A 1 152 ? -47.52827 3.62381   -0.12725  1.000 36.64112 ?  270 LEU A O     1 
ATOM   1156 C CB    . LEU A 1 152 ? -49.56183 4.16009   -2.41719  1.000 40.24386 ?  270 LEU A CB    1 
ATOM   1157 C CG    . LEU A 1 152 ? -50.14020 4.23823   -3.81313  1.000 44.13028 ?  270 LEU A CG    1 
ATOM   1158 C CD1   . LEU A 1 152 ? -50.68804 5.60132   -4.15688  1.000 36.98158 ?  270 LEU A CD1   1 
ATOM   1159 C CD2   . LEU A 1 152 ? -48.97443 3.92073   -4.67852  1.000 43.23839 ?  270 LEU A CD2   1 
ATOM   1160 N N     . LYS A 1 153 ? -46.27281 3.94771   -1.97574  1.000 33.83610 ?  271 LYS A N     1 
ATOM   1161 C CA    . LYS A 1 153 ? -45.14059 4.54954   -1.26495  1.000 31.26546 ?  271 LYS A CA    1 
ATOM   1162 C C     . LYS A 1 153 ? -44.74864 5.86355   -1.92428  1.000 31.98725 ?  271 LYS A C     1 
ATOM   1163 O O     . LYS A 1 153 ? -44.40676 5.88368   -3.11155  1.000 32.40725 ?  271 LYS A O     1 
ATOM   1164 C CB    . LYS A 1 153 ? -43.90928 3.62747   -1.24404  1.000 35.71593 ?  271 LYS A CB    1 
ATOM   1165 C CG    . LYS A 1 153 ? -44.20428 2.17933   -0.89067  1.000 36.28299 ?  271 LYS A CG    1 
ATOM   1166 C CD    . LYS A 1 153 ? -43.96903 1.93036   0.58468   1.000 38.61692 ?  271 LYS A CD    1 
ATOM   1167 C CE    . LYS A 1 153 ? -44.13238 0.43398   0.93280   1.000 38.91990 ?  271 LYS A CE    1 
ATOM   1168 N NZ    . LYS A 1 153 ? -44.02513 0.28956   2.38564   1.000 37.08260 ?  271 LYS A NZ    1 
ATOM   1169 N N     . ILE A 1 154 ? -44.75076 6.94815   -1.15091  1.000 31.52519 ?  272 ILE A N     1 
ATOM   1170 C CA    . ILE A 1 154 ? -44.25106 8.22560   -1.66323  1.000 30.65790 ?  272 ILE A CA    1 
ATOM   1171 C C     . ILE A 1 154 ? -42.73480 8.13631   -1.75745  1.000 30.66870 ?  272 ILE A C     1 
ATOM   1172 O O     . ILE A 1 154 ? -42.05200 7.85240   -0.76631  1.000 30.36914 ?  272 ILE A O     1 
ATOM   1173 C CB    . ILE A 1 154 ? -44.67157 9.38514   -0.75202  1.000 31.06303 ?  272 ILE A CB    1 
ATOM   1174 C CG1   . ILE A 1 154 ? -46.17929 9.59873   -0.83636  1.000 33.41090 ?  272 ILE A CG1   1 
ATOM   1175 C CG2   . ILE A 1 154 ? -43.91221 10.65531  -1.16169  1.000 32.55899 ?  272 ILE A CG2   1 
ATOM   1176 C CD1   . ILE A 1 154 ? -46.70273 10.70609  0.08530   1.000 35.63599 ?  272 ILE A CD1   1 
ATOM   1177 N N     . ALA A 1 155 ? -42.19126 8.37520   -2.94907  1.000 27.98729 ?  273 ALA A N     1 
ATOM   1178 C CA    . ALA A 1 155 ? -40.77529 8.12815   -3.15883  1.000 30.42445 ?  273 ALA A CA    1 
ATOM   1179 C C     . ALA A 1 155 ? -40.13051 9.23521   -3.97305  1.000 34.70606 ?  273 ALA A C     1 
ATOM   1180 O O     . ALA A 1 155 ? -39.27057 8.97186   -4.81954  1.000 32.83560 ?  273 ALA A O     1 
ATOM   1181 C CB    . ALA A 1 155 ? -40.56384 6.77652   -3.85232  1.000 31.05360 ?  273 ALA A CB    1 
ATOM   1182 N N     . ASP A 1 156 ? -40.49871 10.49592  -3.71059  1.000 30.13379 ?  274 ASP A N     1 
ATOM   1183 C CA    . ASP A 1 156 ? -39.88596 11.59664  -4.45092  1.000 32.43556 ?  274 ASP A CA    1 
ATOM   1184 C C     . ASP A 1 156 ? -38.50054 12.00352  -3.92944  1.000 37.16884 ?  274 ASP A C     1 
ATOM   1185 O O     . ASP A 1 156 ? -37.80645 12.77869  -4.59400  1.000 37.95980 ?  274 ASP A O     1 
ATOM   1186 C CB    . ASP A 1 156 ? -40.87242 12.78454  -4.49617  1.000 35.41987 ?  274 ASP A CB    1 
ATOM   1187 C CG    . ASP A 1 156 ? -41.12548 13.40107  -3.14279  1.000 38.35692 ?  274 ASP A CG    1 
ATOM   1188 O OD1   . ASP A 1 156 ? -41.31616 12.63358  -2.18603  1.000 40.34901 ?  274 ASP A OD1   1 
ATOM   1189 O OD2   . ASP A 1 156 ? -41.13169 14.65071  -3.03375  1.000 39.19084 -1 274 ASP A OD2   1 
ATOM   1190 N N     . PHE A 1 157 ? -38.05083 11.43673  -2.82076  1.000 34.75164 ?  275 PHE A N     1 
ATOM   1191 C CA    . PHE A 1 157 ? -36.76427 11.78594  -2.21804  1.000 36.34373 ?  275 PHE A CA    1 
ATOM   1192 C C     . PHE A 1 157 ? -35.58888 11.56158  -3.17366  1.000 34.81159 ?  275 PHE A C     1 
ATOM   1193 O O     . PHE A 1 157 ? -35.42655 10.48018  -3.75490  1.000 35.22460 ?  275 PHE A O     1 
ATOM   1194 C CB    . PHE A 1 157 ? -36.59478 10.94253  -0.94583  1.000 35.93760 ?  275 PHE A CB    1 
ATOM   1195 C CG    . PHE A 1 157 ? -35.22717 11.00403  -0.34006  1.000 38.39812 ?  275 PHE A CG    1 
ATOM   1196 C CD1   . PHE A 1 157 ? -34.75661 12.18481  0.21061   1.000 40.63154 ?  275 PHE A CD1   1 
ATOM   1197 C CD2   . PHE A 1 157 ? -34.42158 9.88037   -0.30081  1.000 42.69616 ?  275 PHE A CD2   1 
ATOM   1198 C CE1   . PHE A 1 157 ? -33.50902 12.24839  0.78312   1.000 39.74794 ?  275 PHE A CE1   1 
ATOM   1199 C CE2   . PHE A 1 157 ? -33.16177 9.93113   0.26376   1.000 41.02626 ?  275 PHE A CE2   1 
ATOM   1200 C CZ    . PHE A 1 157 ? -32.70472 11.11860  0.80936   1.000 42.12540 ?  275 PHE A CZ    1 
ATOM   1201 N N     . GLY A 1 158 ? -34.74874 12.58552  -3.32539  1.000 33.74339 ?  276 GLY A N     1 
ATOM   1202 C CA    . GLY A 1 158 ? -33.55009 12.43971  -4.12909  1.000 33.98703 ?  276 GLY A CA    1 
ATOM   1203 C C     . GLY A 1 158 ? -33.73448 12.72928  -5.59954  1.000 34.66959 ?  276 GLY A C     1 
ATOM   1204 O O     . GLY A 1 158 ? -32.83936 12.41118  -6.39278  1.000 34.28406 ?  276 GLY A O     1 
ATOM   1205 N N     . TRP A 1 159 ? -34.87781 13.31152  -5.96897  1.000 32.96765 ?  277 TRP A N     1 
ATOM   1206 C CA    . TRP A 1 159 ? -35.23667 13.77648  -7.30780  1.000 34.69379 ?  277 TRP A CA    1 
ATOM   1207 C C     . TRP A 1 159 ? -35.68992 12.64721  -8.22306  1.000 33.48919 ?  277 TRP A C     1 
ATOM   1208 O O     . TRP A 1 159 ? -35.51434 11.45650  -7.92075  1.000 30.47968 ?  277 TRP A O     1 
ATOM   1209 C CB    . TRP A 1 159 ? -34.08556 14.56343  -7.95392  1.000 38.33471 ?  277 TRP A CB    1 
ATOM   1210 C CG    . TRP A 1 159 ? -33.78396 15.88391  -7.26162  1.000 40.15995 ?  277 TRP A CG    1 
ATOM   1211 C CD1   . TRP A 1 159 ? -34.47998 17.05515  -7.39571  1.000 44.99422 ?  277 TRP A CD1   1 
ATOM   1212 C CD2   . TRP A 1 159 ? -32.72291 16.15323  -6.32839  1.000 39.51555 ?  277 TRP A CD2   1 
ATOM   1213 N NE1   . TRP A 1 159 ? -33.90643 18.04188  -6.61560  1.000 46.89596 ?  277 TRP A NE1   1 
ATOM   1214 C CE2   . TRP A 1 159 ? -32.83119 17.51164  -5.94989  1.000 42.40903 ?  277 TRP A CE2   1 
ATOM   1215 C CE3   . TRP A 1 159 ? -31.68516 15.38319  -5.78993  1.000 40.30993 ?  277 TRP A CE3   1 
ATOM   1216 C CZ2   . TRP A 1 159 ? -31.94644 18.11242  -5.05112  1.000 45.20005 ?  277 TRP A CZ2   1 
ATOM   1217 C CZ3   . TRP A 1 159 ? -30.80034 15.98325  -4.89967  1.000 40.92658 ?  277 TRP A CZ3   1 
ATOM   1218 C CH2   . TRP A 1 159 ? -30.94076 17.33883  -4.54071  1.000 43.52615 ?  277 TRP A CH2   1 
ATOM   1219 N N     . SER A 1 160 ? -36.30708 13.03986  -9.33751  1.000 35.80265 ?  278 SER A N     1 
ATOM   1220 C CA    . SER A 1 160 ? -36.94425 12.10131  -10.24621 1.000 35.55845 ?  278 SER A CA    1 
ATOM   1221 C C     . SER A 1 160 ? -35.92458 11.15348  -10.87243 1.000 34.35296 ?  278 SER A C     1 
ATOM   1222 O O     . SER A 1 160 ? -34.77579 11.51888  -11.14885 1.000 33.16264 ?  278 SER A O     1 
ATOM   1223 C CB    . SER A 1 160 ? -37.68537 12.87112  -11.34796 1.000 34.76105 ?  278 SER A CB    1 
ATOM   1224 O OG    . SER A 1 160 ? -38.89756 13.43434  -10.86277 1.000 39.77937 ?  278 SER A OG    1 
ATOM   1225 N N     . VAL A 1 161 ? -36.37404 9.92093   -11.10808 1.000 31.55744 ?  279 VAL A N     1 
ATOM   1226 C CA    . VAL A 1 161 ? -35.60885 8.86360   -11.76354 1.000 34.16260 ?  279 VAL A CA    1 
ATOM   1227 C C     . VAL A 1 161 ? -36.62205 8.07330   -12.57473 1.000 37.97715 ?  279 VAL A C     1 
ATOM   1228 O O     . VAL A 1 161 ? -37.60321 7.57291   -12.00641 1.000 38.48522 ?  279 VAL A O     1 
ATOM   1229 C CB    . VAL A 1 161 ? -34.89929 7.94890   -10.73870 1.000 34.55881 ?  279 VAL A CB    1 
ATOM   1230 C CG1   . VAL A 1 161 ? -34.43200 6.66369   -11.38040 1.000 37.98426 ?  279 VAL A CG1   1 
ATOM   1231 C CG2   . VAL A 1 161 ? -33.73218 8.67025   -10.07390 1.000 34.74490 ?  279 VAL A CG2   1 
ATOM   1232 N N     . HIS A 1 162 ? -36.40649 7.93656   -13.88868 1.000 32.78595 ?  280 HIS A N     1 
ATOM   1233 C CA    . HIS A 1 162 ? -37.38096 7.26266   -14.73821 1.000 36.23626 ?  280 HIS A CA    1 
ATOM   1234 C C     . HIS A 1 162 ? -36.88889 5.88950   -15.18335 1.000 35.05465 ?  280 HIS A C     1 
ATOM   1235 O O     . HIS A 1 162 ? -35.70162 5.69820   -15.48814 1.000 32.98662 ?  280 HIS A O     1 
ATOM   1236 C CB    . HIS A 1 162 ? -37.73346 8.10144   -15.96933 1.000 35.03932 ?  280 HIS A CB    1 
ATOM   1237 C CG    . HIS A 1 162 ? -36.55980 8.41764   -16.84060 1.000 39.82726 ?  280 HIS A CG    1 
ATOM   1238 N ND1   . HIS A 1 162 ? -35.78201 9.54271   -16.66455 1.000 38.60570 ?  280 HIS A ND1   1 
ATOM   1239 C CD2   . HIS A 1 162 ? -36.00608 7.73603   -17.87110 1.000 40.43862 ?  280 HIS A CD2   1 
ATOM   1240 C CE1   . HIS A 1 162 ? -34.81322 9.55163   -17.56383 1.000 42.93759 ?  280 HIS A CE1   1 
ATOM   1241 N NE2   . HIS A 1 162 ? -34.92065 8.46066   -18.30101 1.000 40.79729 ?  280 HIS A NE2   1 
ATOM   1242 N N     . ALA A 1 163 ? -37.81634 4.94337   -15.21771 1.000 34.10587 ?  281 ALA A N     1 
ATOM   1243 C CA    . ALA A 1 163 ? -37.57612 3.61851   -15.75739 1.000 33.29417 ?  281 ALA A CA    1 
ATOM   1244 C C     . ALA A 1 163 ? -37.60405 3.67508   -17.28121 1.000 34.70657 ?  281 ALA A C     1 
ATOM   1245 O O     . ALA A 1 163 ? -38.18823 4.59688   -17.86634 1.000 34.91879 ?  281 ALA A O     1 
ATOM   1246 C CB    . ALA A 1 163 ? -38.63880 2.64890   -15.23910 1.000 37.78889 ?  281 ALA A CB    1 
ATOM   1247 N N     . PRO A 1 164 ? -36.97147 2.70419   -17.95394 1.000 36.05657 ?  282 PRO A N     1 
ATOM   1248 C CA    . PRO A 1 164 ? -36.91530 2.75973   -19.42605 1.000 36.96162 ?  282 PRO A CA    1 
ATOM   1249 C C     . PRO A 1 164 ? -38.28013 2.79451   -20.07282 1.000 35.73707 ?  282 PRO A C     1 
ATOM   1250 O O     . PRO A 1 164 ? -38.41788 3.35229   -21.16760 1.000 42.10031 ?  282 PRO A O     1 
ATOM   1251 C CB    . PRO A 1 164 ? -36.15641 1.47581   -19.80436 1.000 39.13271 ?  282 PRO A CB    1 
ATOM   1252 C CG    . PRO A 1 164 ? -35.43312 1.07660   -18.57430 1.000 39.96215 ?  282 PRO A CG    1 
ATOM   1253 C CD    . PRO A 1 164 ? -36.28451 1.51131   -17.41996 1.000 37.13639 ?  282 PRO A CD    1 
ATOM   1254 N N     . SER A 1 165 ? -39.29259 2.22504   -19.41622 1.000 38.03112 ?  283 SER A N     1 
ATOM   1255 C CA    . SER A 1 165 ? -40.65504 2.15914   -19.93588 1.000 41.81065 ?  283 SER A CA    1 
ATOM   1256 C C     . SER A 1 165 ? -41.37083 3.50446   -19.92974 1.000 41.45267 ?  283 SER A C     1 
ATOM   1257 O O     . SER A 1 165 ? -42.42119 3.62126   -20.56545 1.000 43.21990 ?  283 SER A O     1 
ATOM   1258 C CB    . SER A 1 165 ? -41.48074 1.15584   -19.12204 1.000 42.95275 ?  283 SER A CB    1 
ATOM   1259 O OG    . SER A 1 165 ? -41.45456 1.44052   -17.72516 1.000 41.96224 ?  283 SER A OG    1 
ATOM   1260 N N     . SER A 1 166 ? -40.83756 4.50250   -19.22863 1.000 42.14345 ?  284 SER A N     1 
ATOM   1261 C CA    . SER A 1 166 ? -41.51416 5.78597   -19.05594 1.000 40.96487 ?  284 SER A CA    1 
ATOM   1262 C C     . SER A 1 166 ? -41.58733 6.56043   -20.36735 1.000 40.17804 ?  284 SER A C     1 
ATOM   1263 O O     . SER A 1 166 ? -40.66205 6.53031   -21.17771 1.000 41.62507 ?  284 SER A O     1 
ATOM   1264 C CB    . SER A 1 166 ? -40.77712 6.61455   -18.00187 1.000 42.15116 ?  284 SER A CB    1 
ATOM   1265 O OG    . SER A 1 166 ? -41.05463 8.00216   -18.13985 1.000 50.14270 ?  284 SER A OG    1 
ATOM   1266 N N     . ARG A 1 167 ? -42.70024 7.26169   -20.57223 1.000 38.95251 ?  285 ARG A N     1 
ATOM   1267 C CA    . ARG A 1 167 ? -42.88379 8.10093   -21.75019 1.000 40.12043 ?  285 ARG A CA    1 
ATOM   1268 C C     . ARG A 1 167 ? -43.12528 9.56951   -21.40732 1.000 41.20962 ?  285 ARG A C     1 
ATOM   1269 O O     . ARG A 1 167 ? -43.46305 10.35074  -22.30152 1.000 44.85741 ?  285 ARG A O     1 
ATOM   1270 C CB    . ARG A 1 167 ? -44.04336 7.55985   -22.59245 1.000 40.04714 ?  285 ARG A CB    1 
ATOM   1271 C CG    . ARG A 1 167 ? -43.74908 6.21040   -23.29853 1.000 42.23959 ?  285 ARG A CG    1 
ATOM   1272 C CD    . ARG A 1 167 ? -42.48976 6.28078   -24.19406 1.000 46.05638 ?  285 ARG A CD    1 
ATOM   1273 N NE    . ARG A 1 167 ? -42.10732 4.97622   -24.73246 1.000 48.32772 ?  285 ARG A NE    1 
ATOM   1274 C CZ    . ARG A 1 167 ? -41.14365 4.19396   -24.25387 1.000 53.27624 ?  285 ARG A CZ    1 
ATOM   1275 N NH1   . ARG A 1 167 ? -40.33521 4.59459   -23.28008 1.000 47.46889 ?  285 ARG A NH1   1 
ATOM   1276 N NH2   . ARG A 1 167 ? -40.97682 2.98006   -24.77509 1.000 56.07292 ?  285 ARG A NH2   1 
ATOM   1277 N N     . ARG A 1 168 ? -42.97113 9.96647   -20.14522 1.000 38.07753 ?  286 ARG A N     1 
ATOM   1278 C CA    . ARG A 1 168 ? -43.18256 11.34595  -19.70577 1.000 35.80880 ?  286 ARG A CA    1 
ATOM   1279 C C     . ARG A 1 168 ? -41.91151 11.82688  -19.03140 1.000 35.31414 ?  286 ARG A C     1 
ATOM   1280 O O     . ARG A 1 168 ? -41.44427 11.18856  -18.08746 1.000 38.60082 ?  286 ARG A O     1 
ATOM   1281 C CB    . ARG A 1 168 ? -44.37832 11.43539  -18.74399 1.000 39.16459 ?  286 ARG A CB    1 
ATOM   1282 C CG    . ARG A 1 168 ? -44.67760 12.84929  -18.27897 1.000 37.53536 ?  286 ARG A CG    1 
ATOM   1283 C CD    . ARG A 1 168 ? -46.11971 12.99570  -17.77775 1.000 36.91769 ?  286 ARG A CD    1 
ATOM   1284 N NE    . ARG A 1 168 ? -46.35919 12.36012  -16.48494 1.000 34.73658 ?  286 ARG A NE    1 
ATOM   1285 C CZ    . ARG A 1 168 ? -47.57293 12.12050  -15.99895 1.000 37.57832 ?  286 ARG A CZ    1 
ATOM   1286 N NH1   . ARG A 1 168 ? -48.66605 12.39744  -16.69644 1.000 36.83207 ?  286 ARG A NH1   1 
ATOM   1287 N NH2   . ARG A 1 168 ? -47.69448 11.61952  -14.77554 1.000 31.88905 ?  286 ARG A NH2   1 
ATOM   1288 N N     . THR A 1 169 ? -41.33492 12.93391  -19.51662 1.000 33.95083 ?  287 THR A N     1 
ATOM   1289 C CA    . THR A 1 169 ? -40.09157 13.41574  -18.90467 1.000 31.83770 ?  287 THR A CA    1 
ATOM   1290 C C     . THR A 1 169 ? -40.33188 14.01809  -17.51618 1.000 34.41080 ?  287 THR A C     1 
ATOM   1291 O O     . THR A 1 169 ? -41.46420 14.39983  -17.18227 1.000 32.16127 ?  287 THR A O     1 
ATOM   1292 C CB    . THR A 1 169 ? -39.38945 14.49380  -19.77204 1.000 35.87859 ?  287 THR A CB    1 
ATOM   1293 O OG1   . THR A 1 169 ? -40.13514 15.71045  -19.68832 1.000 35.29757 ?  287 THR A OG1   1 
ATOM   1294 C CG2   . THR A 1 169 ? -39.24235 14.04551  -21.23764 1.000 35.93369 ?  287 THR A CG2   1 
HETATM 1295 N N     . TPO A 1 170 ? -39.24452 14.15335  -16.75252 1.000 34.66104 ?  288 TPO A N     1 
HETATM 1296 C CA    . TPO A 1 170 ? -39.26311 14.76068  -15.41152 1.000 32.06951 ?  288 TPO A CA    1 
HETATM 1297 C CB    . TPO A 1 170 ? -37.84669 14.79952  -14.83362 1.000 38.35430 ?  288 TPO A CB    1 
HETATM 1298 C CG2   . TPO A 1 170 ? -37.76545 15.69791  -13.58602 1.000 39.06761 ?  288 TPO A CG2   1 
HETATM 1299 O OG1   . TPO A 1 170 ? -37.52529 13.47867  -14.43179 1.000 39.79672 ?  288 TPO A OG1   1 
HETATM 1300 P P     . TPO A 1 170 ? -36.32870 12.85456  -15.30160 1.000 42.60831 ?  288 TPO A P     1 
HETATM 1301 O O1P   . TPO A 1 170 ? -35.03959 13.55914  -15.00954 1.000 41.22704 ?  288 TPO A O1P   1 
HETATM 1302 O O2P   . TPO A 1 170 ? -36.69177 12.90592  -16.87529 1.000 41.80154 -1 288 TPO A O2P   1 
HETATM 1303 O O3P   . TPO A 1 170 ? -36.24499 11.33191  -14.80042 1.000 42.37940 ?  288 TPO A O3P   1 
HETATM 1304 C C     . TPO A 1 170 ? -39.86491 16.15478  -15.41946 1.000 38.84230 ?  288 TPO A C     1 
HETATM 1305 O O     . TPO A 1 170 ? -40.74590 16.45949  -14.59912 1.000 35.03945 ?  288 TPO A O     1 
ATOM   1306 N N     . LEU A 1 171 ? -39.42912 17.00941  -16.34524 1.000 34.60361 ?  289 LEU A N     1 
ATOM   1307 C CA    . LEU A 1 171 ? -39.99333 18.37169  -16.37487 1.000 37.68504 ?  289 LEU A CA    1 
ATOM   1308 C C     . LEU A 1 171 ? -41.48636 18.38517  -16.67762 1.000 38.16810 ?  289 LEU A C     1 
ATOM   1309 O O     . LEU A 1 171 ? -42.24957 19.15767  -16.07575 1.000 37.74279 ?  289 LEU A O     1 
ATOM   1310 C CB    . LEU A 1 171 ? -39.28051 19.26933  -17.39384 1.000 39.89580 ?  289 LEU A CB    1 
ATOM   1311 C CG    . LEU A 1 171 ? -37.87822 19.76066  -17.04988 1.000 42.80003 ?  289 LEU A CG    1 
ATOM   1312 C CD1   . LEU A 1 171 ? -37.36036 20.60560  -18.19491 1.000 43.77816 ?  289 LEU A CD1   1 
ATOM   1313 C CD2   . LEU A 1 171 ? -37.87334 20.52856  -15.72610 1.000 42.32750 ?  289 LEU A CD2   1 
ATOM   1314 N N     . ALA A 1 172 ? -41.91034 17.52984  -17.61030 1.000 35.16726 ?  290 ALA A N     1 
ATOM   1315 C CA    . ALA A 1 172 ? -43.31657 17.50672  -17.99833 1.000 34.30910 ?  290 ALA A CA    1 
ATOM   1316 C C     . ALA A 1 172 ? -44.19574 16.97856  -16.86922 1.000 35.24589 ?  290 ALA A C     1 
ATOM   1317 O O     . ALA A 1 172 ? -45.24392 17.55979  -16.55630 1.000 34.62703 ?  290 ALA A O     1 
ATOM   1318 C CB    . ALA A 1 172 ? -43.49587 16.66064  -19.26178 1.000 34.51835 ?  290 ALA A CB    1 
ATOM   1319 N N     . GLY A 1 173 ? -43.80282 15.85881  -16.26239 1.000 34.66320 ?  291 GLY A N     1 
ATOM   1320 C CA    . GLY A 1 173 ? -44.59347 15.31223  -15.16520 1.000 29.71447 ?  291 GLY A CA    1 
ATOM   1321 C C     . GLY A 1 173 ? -44.65159 16.24007  -13.96711 1.000 36.31159 ?  291 GLY A C     1 
ATOM   1322 O O     . GLY A 1 173 ? -45.69155 16.36921  -13.31752 1.000 34.97255 ?  291 GLY A O     1 
ATOM   1323 N N     . THR A 1 174 ? -43.52931 16.88096  -13.63691 1.000 31.00687 ?  292 THR A N     1 
ATOM   1324 C CA    . THR A 1 174 ? -43.54668 17.79066  -12.50168 1.000 34.43342 ?  292 THR A CA    1 
ATOM   1325 C C     . THR A 1 174 ? -44.41628 19.01504  -12.79647 1.000 36.95959 ?  292 THR A C     1 
ATOM   1326 O O     . THR A 1 174 ? -45.21816 19.43213  -11.94805 1.000 37.81325 ?  292 THR A O     1 
ATOM   1327 C CB    . THR A 1 174 ? -42.11884 18.18688  -12.13256 1.000 38.14064 ?  292 THR A CB    1 
ATOM   1328 O OG1   . THR A 1 174 ? -41.43930 17.03509  -11.60619 1.000 37.43574 ?  292 THR A OG1   1 
ATOM   1329 C CG2   . THR A 1 174 ? -42.14380 19.27785  -11.05972 1.000 41.07400 ?  292 THR A CG2   1 
ATOM   1330 N N     . LEU A 1 175 ? -44.31601 19.56212  -14.00991 1.000 35.69205 ?  293 LEU A N     1 
ATOM   1331 C CA    . LEU A 1 175 ? -45.16068 20.69564  -14.39054 1.000 39.51812 ?  293 LEU A CA    1 
ATOM   1332 C C     . LEU A 1 175 ? -46.64014 20.32847  -14.34243 1.000 40.13664 ?  293 LEU A C     1 
ATOM   1333 O O     . LEU A 1 175 ? -47.47923 21.12067  -13.87641 1.000 35.58280 ?  293 LEU A O     1 
ATOM   1334 C CB    . LEU A 1 175 ? -44.78656 21.17908  -15.78698 1.000 37.48047 ?  293 LEU A CB    1 
ATOM   1335 C CG    . LEU A 1 175 ? -45.77673 22.19327  -16.38491 1.000 44.36924 ?  293 LEU A CG    1 
ATOM   1336 C CD1   . LEU A 1 175 ? -45.98432 23.39134  -15.44009 1.000 45.38645 ?  293 LEU A CD1   1 
ATOM   1337 C CD2   . LEU A 1 175 ? -45.38048 22.65768  -17.77693 1.000 42.46617 ?  293 LEU A CD2   1 
ATOM   1338 N N     . ASP A 1 176 ? -46.97859 19.12244  -14.80363 1.000 34.06321 ?  294 ASP A N     1 
ATOM   1339 C CA    . ASP A 1 176 ? -48.37190 18.69716  -14.79331 1.000 34.27276 ?  294 ASP A CA    1 
ATOM   1340 C C     . ASP A 1 176 ? -48.98638 18.79397  -13.40695 1.000 34.98486 ?  294 ASP A C     1 
ATOM   1341 O O     . ASP A 1 176 ? -50.20554 18.94297  -13.28719 1.000 32.80194 ?  294 ASP A O     1 
ATOM   1342 C CB    . ASP A 1 176 ? -48.49267 17.26321  -15.30509 1.000 34.05015 ?  294 ASP A CB    1 
ATOM   1343 C CG    . ASP A 1 176 ? -48.56071 17.18721  -16.80938 1.000 41.96620 ?  294 ASP A CG    1 
ATOM   1344 O OD1   . ASP A 1 176 ? -49.07525 18.14373  -17.44192 1.000 45.04874 ?  294 ASP A OD1   1 
ATOM   1345 O OD2   . ASP A 1 176 ? -48.11054 16.16015  -17.35311 1.000 37.09037 -1 294 ASP A OD2   1 
ATOM   1346 N N     . TYR A 1 177 ? -48.16001 18.72252  -12.35410 1.000 31.56076 ?  295 TYR A N     1 
ATOM   1347 C CA    . TYR A 1 177 ? -48.63253 18.66374  -10.98708 1.000 31.39992 ?  295 TYR A CA    1 
ATOM   1348 C C     . TYR A 1 177 ? -48.43078 19.95455  -10.19803 1.000 34.18665 ?  295 TYR A C     1 
ATOM   1349 O O     . TYR A 1 177 ? -48.82422 19.99864  -9.02954  1.000 34.40189 ?  295 TYR A O     1 
ATOM   1350 C CB    . TYR A 1 177 ? -47.97054 17.48559  -10.25970 1.000 31.31395 ?  295 TYR A CB    1 
ATOM   1351 C CG    . TYR A 1 177 ? -48.72625 16.23292  -10.58516 1.000 33.14530 ?  295 TYR A CG    1 
ATOM   1352 C CD1   . TYR A 1 177 ? -48.62088 15.63900  -11.83981 1.000 33.26706 ?  295 TYR A CD1   1 
ATOM   1353 C CD2   . TYR A 1 177 ? -49.60197 15.69187  -9.67577  1.000 31.03325 ?  295 TYR A CD2   1 
ATOM   1354 C CE1   . TYR A 1 177 ? -49.35473 14.51007  -12.15334 1.000 32.61509 ?  295 TYR A CE1   1 
ATOM   1355 C CE2   . TYR A 1 177 ? -50.33482 14.57897  -9.97104  1.000 31.11327 ?  295 TYR A CE2   1 
ATOM   1356 C CZ    . TYR A 1 177 ? -50.22352 13.99336  -11.20473 1.000 31.54449 ?  295 TYR A CZ    1 
ATOM   1357 O OH    . TYR A 1 177 ? -50.98338 12.88340  -11.48574 1.000 34.21082 ?  295 TYR A OH    1 
ATOM   1358 N N     . LEU A 1 178 ? -47.90248 21.00667  -10.81382 1.000 33.21293 ?  296 LEU A N     1 
ATOM   1359 C CA    . LEU A 1 178 ? -47.60255 22.24490  -10.07358 1.000 37.42533 ?  296 LEU A CA    1 
ATOM   1360 C C     . LEU A 1 178 ? -48.86124 23.07494  -9.82383  1.000 35.27194 ?  296 LEU A C     1 
ATOM   1361 O O     . LEU A 1 178 ? -49.72396 23.18582  -10.69713 1.000 30.33785 ?  296 LEU A O     1 
ATOM   1362 C CB    . LEU A 1 178 ? -46.59314 23.10010  -10.80846 1.000 36.78696 ?  296 LEU A CB    1 
ATOM   1363 C CG    . LEU A 1 178 ? -45.13033 22.66558  -10.84772 1.000 42.23041 ?  296 LEU A CG    1 
ATOM   1364 C CD1   . LEU A 1 178 ? -44.31200 23.68336  -11.61549 1.000 44.53220 ?  296 LEU A CD1   1 
ATOM   1365 C CD2   . LEU A 1 178 ? -44.60846 22.52912  -9.41576  1.000 43.88975 ?  296 LEU A CD2   1 
ATOM   1366 N N     . PRO A 1 179 ? -48.97425 23.68527  -8.64823  1.000 33.91775 ?  297 PRO A N     1 
ATOM   1367 C CA    . PRO A 1 179 ? -50.17722 24.42885  -8.31318  1.000 29.99365 ?  297 PRO A CA    1 
ATOM   1368 C C     . PRO A 1 179 ? -50.09865 25.85209  -8.82955  1.000 31.04133 ?  297 PRO A C     1 
ATOM   1369 O O     . PRO A 1 179 ? -49.00003 26.36720  -9.10999  1.000 33.14787 ?  297 PRO A O     1 
ATOM   1370 C CB    . PRO A 1 179 ? -50.19208 24.38055  -6.77855  1.000 33.76640 ?  297 PRO A CB    1 
ATOM   1371 C CG    . PRO A 1 179 ? -48.71737 24.41561  -6.43249  1.000 36.36672 ?  297 PRO A CG    1 
ATOM   1372 C CD    . PRO A 1 179 ? -48.03845 23.59795  -7.50758  1.000 38.03153 ?  297 PRO A CD    1 
ATOM   1373 N N     . PRO A 1 180 ? -51.24934 26.51779  -8.98489  1.000 32.38843 ?  298 PRO A N     1 
ATOM   1374 C CA    . PRO A 1 180 ? -51.22415 27.88494  -9.52733  1.000 32.13008 ?  298 PRO A CA    1 
ATOM   1375 C C     . PRO A 1 180 ? -50.34167 28.82080  -8.73343  1.000 36.25268 ?  298 PRO A C     1 
ATOM   1376 O O     . PRO A 1 180 ? -49.64143 29.64328  -9.33409  1.000 36.72095 ?  298 PRO A O     1 
ATOM   1377 C CB    . PRO A 1 180 ? -52.69773 28.32680  -9.47438  1.000 35.09996 ?  298 PRO A CB    1 
ATOM   1378 C CG    . PRO A 1 180 ? -53.47267 27.08379  -9.44704  1.000 34.88501 ?  298 PRO A CG    1 
ATOM   1379 C CD    . PRO A 1 180 ? -52.61696 26.03745  -8.74764  1.000 28.71106 ?  298 PRO A CD    1 
ATOM   1380 N N     . GLU A 1 181 ? -50.35624 28.72908  -7.39860  1.000 35.03066 ?  299 GLU A N     1 
ATOM   1381 C CA    . GLU A 1 181 ? -49.57895 29.68371  -6.61735  1.000 38.08046 ?  299 GLU A CA    1 
ATOM   1382 C C     . GLU A 1 181 ? -48.08836 29.59095  -6.91620  1.000 42.14436 ?  299 GLU A C     1 
ATOM   1383 O O     . GLU A 1 181 ? -47.38311 30.60309  -6.82472  1.000 46.97590 ?  299 GLU A O     1 
ATOM   1384 C CB    . GLU A 1 181 ? -49.84741 29.50243  -5.12292  1.000 39.87990 ?  299 GLU A CB    1 
ATOM   1385 C CG    . GLU A 1 181 ? -49.60481 28.10727  -4.58564  1.000 38.43893 ?  299 GLU A CG    1 
ATOM   1386 C CD    . GLU A 1 181 ? -50.87506 27.26531  -4.55300  1.000 35.60911 ?  299 GLU A CD    1 
ATOM   1387 O OE1   . GLU A 1 181 ? -51.69788 27.36726  -5.49500  1.000 33.47556 ?  299 GLU A OE1   1 
ATOM   1388 O OE2   . GLU A 1 181 ? -51.03541 26.46002  -3.60733  1.000 34.93464 -1 299 GLU A OE2   1 
ATOM   1389 N N     . MET A 1 182 ? -47.58021 28.41225  -7.29295  1.000 36.58580 ?  300 MET A N     1 
ATOM   1390 C CA    . MET A 1 182 ? -46.17286 28.33521  -7.65957  1.000 42.39445 ?  300 MET A CA    1 
ATOM   1391 C C     . MET A 1 182 ? -45.92212 28.64262  -9.12070  1.000 48.48070 ?  300 MET A C     1 
ATOM   1392 O O     . MET A 1 182 ? -44.77832 28.93555  -9.48459  1.000 52.29573 ?  300 MET A O     1 
ATOM   1393 C CB    . MET A 1 182 ? -45.54028 26.97560  -7.31953  1.000 42.99418 ?  300 MET A CB    1 
ATOM   1394 C CG    . MET A 1 182 ? -45.71969 26.53456  -5.86999  1.000 45.73323 ?  300 MET A CG    1 
ATOM   1395 S SD    . MET A 1 182 ? -45.16217 24.85001  -5.58262  1.000 50.87805 ?  300 MET A SD    1 
ATOM   1396 C CE    . MET A 1 182 ? -43.64843 24.85020  -6.54046  1.000 52.07147 ?  300 MET A CE    1 
ATOM   1397 N N     . ILE A 1 183 ? -46.95165 28.61012  -9.96280  1.000 44.87566 ?  301 ILE A N     1 
ATOM   1398 C CA    . ILE A 1 183 ? -46.76134 29.08420  -11.32910 1.000 48.89134 ?  301 ILE A CA    1 
ATOM   1399 C C     . ILE A 1 183 ? -46.88753 30.60097  -11.37716 1.000 48.90348 ?  301 ILE A C     1 
ATOM   1400 O O     . ILE A 1 183 ? -46.15230 31.27947  -12.10328 1.000 51.94564 ?  301 ILE A O     1 
ATOM   1401 C CB    . ILE A 1 183 ? -47.75372 28.37165  -12.26612 1.000 42.93414 ?  301 ILE A CB    1 
ATOM   1402 C CG1   . ILE A 1 183 ? -47.21964 26.96718  -12.56264 1.000 49.07944 ?  301 ILE A CG1   1 
ATOM   1403 C CG2   . ILE A 1 183 ? -47.98501 29.17325  -13.55135 1.000 47.49091 ?  301 ILE A CG2   1 
ATOM   1404 C CD1   . ILE A 1 183 ? -48.08710 26.16286  -13.48493 1.000 45.37169 ?  301 ILE A CD1   1 
ATOM   1405 N N     . GLU A 1 184 ? -47.79463 31.15642  -10.58081 1.000 45.01609 ?  302 GLU A N     1 
ATOM   1406 C CA    . GLU A 1 184 ? -47.95171 32.59688  -10.47497 1.000 47.61540 ?  302 GLU A CA    1 
ATOM   1407 C C     . GLU A 1 184 ? -46.89362 33.23069  -9.58710  1.000 50.28460 ?  302 GLU A C     1 
ATOM   1408 O O     . GLU A 1 184 ? -46.88998 34.45564  -9.43516  1.000 50.62407 ?  302 GLU A O     1 
ATOM   1409 C CB    . GLU A 1 184 ? -49.34347 32.91668  -9.94159  1.000 47.78024 ?  302 GLU A CB    1 
ATOM   1410 C CG    . GLU A 1 184 ? -50.43278 32.60822  -10.93691 1.000 45.86571 ?  302 GLU A CG    1 
ATOM   1411 C CD    . GLU A 1 184 ? -51.74390 32.33168  -10.26255 1.000 49.06717 ?  302 GLU A CD    1 
ATOM   1412 O OE1   . GLU A 1 184 ? -51.87223 32.68156  -9.06783  1.000 49.20671 ?  302 GLU A OE1   1 
ATOM   1413 O OE2   . GLU A 1 184 ? -52.64360 31.75769  -10.91655 1.000 45.27649 -1 302 GLU A OE2   1 
ATOM   1414 N N     . GLY A 1 185 ? -46.01553 32.42372  -8.99848  1.000 48.80118 ?  303 GLY A N     1 
ATOM   1415 C CA    . GLY A 1 185 ? -44.90275 32.92699  -8.22048  1.000 52.99882 ?  303 GLY A CA    1 
ATOM   1416 C C     . GLY A 1 185 ? -45.27028 33.46441  -6.85909  1.000 52.47312 ?  303 GLY A C     1 
ATOM   1417 O O     . GLY A 1 185 ? -44.55377 34.31889  -6.33170  1.000 55.78500 ?  303 GLY A O     1 
ATOM   1418 N N     . ARG A 1 186 ? -46.37049 33.00022  -6.27277  1.000 49.35006 ?  304 ARG A N     1 
ATOM   1419 C CA    . ARG A 1 186 ? -46.77231 33.49194  -4.96540  1.000 49.96775 ?  304 ARG A CA    1 
ATOM   1420 C C     . ARG A 1 186 ? -46.24290 32.60018  -3.84479  1.000 49.01465 ?  304 ARG A C     1 
ATOM   1421 O O     . ARG A 1 186 ? -45.71881 31.50595  -4.06827  1.000 49.80635 ?  304 ARG A O     1 
ATOM   1422 C CB    . ARG A 1 186 ? -48.29696 33.62433  -4.88336  1.000 50.55046 ?  304 ARG A CB    1 
ATOM   1423 C CG    . ARG A 1 186 ? -48.91466 34.29140  -6.11265  1.000 53.52190 ?  304 ARG A CG    1 
ATOM   1424 C CD    . ARG A 1 186 ? -50.42957 34.35605  -6.04107  1.000 57.00538 ?  304 ARG A CD    1 
ATOM   1425 N NE    . ARG A 1 186 ? -50.99922 34.85441  -7.28718  1.000 63.06912 ?  304 ARG A NE    1 
ATOM   1426 C CZ    . ARG A 1 186 ? -52.28605 35.12118  -7.48103  1.000 64.89221 ?  304 ARG A CZ    1 
ATOM   1427 N NH1   . ARG A 1 186 ? -53.17530 35.00237  -6.50619  1.000 69.20473 ?  304 ARG A NH1   1 
ATOM   1428 N NH2   . ARG A 1 186 ? -52.69143 35.51884  -8.68411  1.000 60.04434 ?  304 ARG A NH2   1 
ATOM   1429 N N     . MET A 1 187 ? -46.36445 33.10937  -2.61857  1.000 44.88167 ?  305 MET A N     1 
ATOM   1430 C CA    . MET A 1 187 ? -46.12574 32.30758  -1.42934  1.000 49.20161 ?  305 MET A CA    1 
ATOM   1431 C C     . MET A 1 187 ? -46.94157 31.02461  -1.50014  1.000 49.28323 ?  305 MET A C     1 
ATOM   1432 O O     . MET A 1 187 ? -48.06835 31.01029  -1.99889  1.000 45.82902 ?  305 MET A O     1 
ATOM   1433 C CB    . MET A 1 187 ? -46.53722 33.09724  -0.18727  1.000 53.77751 ?  305 MET A CB    1 
ATOM   1434 C CG    . MET A 1 187 ? -45.52253 34.09279  0.32864   1.000 56.85543 ?  305 MET A CG    1 
ATOM   1435 S SD    . MET A 1 187 ? -45.84740 34.37487  2.07910   1.000 64.18795 ?  305 MET A SD    1 
ATOM   1436 C CE    . MET A 1 187 ? -47.64427 34.39786  2.10069   1.000 53.03036 ?  305 MET A CE    1 
ATOM   1437 N N     . HIS A 1 188 ? -46.38836 29.93516  -0.99063  1.000 44.50915 ?  306 HIS A N     1 
ATOM   1438 C CA    . HIS A 1 188 ? -47.19842 28.73199  -0.90868  1.000 45.02919 ?  306 HIS A CA    1 
ATOM   1439 C C     . HIS A 1 188 ? -47.06280 28.11597  0.47427   1.000 48.34866 ?  306 HIS A C     1 
ATOM   1440 O O     . HIS A 1 188 ? -46.16666 28.46656  1.25136   1.000 48.57104 ?  306 HIS A O     1 
ATOM   1441 C CB    . HIS A 1 188 ? -46.83233 27.73578  -2.00374  1.000 45.11258 ?  306 HIS A CB    1 
ATOM   1442 C CG    . HIS A 1 188 ? -45.42657 27.23648  -1.92686  1.000 48.39257 ?  306 HIS A CG    1 
ATOM   1443 N ND1   . HIS A 1 188 ? -45.03765 26.22794  -1.07030  1.000 54.23568 ?  306 HIS A ND1   1 
ATOM   1444 C CD2   . HIS A 1 188 ? -44.32251 27.58465  -2.62497  1.000 45.86741 ?  306 HIS A CD2   1 
ATOM   1445 C CE1   . HIS A 1 188 ? -43.74934 25.98757  -1.23575  1.000 48.42571 ?  306 HIS A CE1   1 
ATOM   1446 N NE2   . HIS A 1 188 ? -43.29306 26.79723  -2.17430  1.000 51.84638 ?  306 HIS A NE2   1 
ATOM   1447 N N     . ASP A 1 189 ? -47.98296 27.20505  0.77149   1.000 44.12485 ?  307 ASP A N     1 
ATOM   1448 C CA    . ASP A 1 189 ? -48.08379 26.56105  2.08145   1.000 45.40607 ?  307 ASP A CA    1 
ATOM   1449 C C     . ASP A 1 189 ? -48.37576 25.08664  1.82098   1.000 41.16997 ?  307 ASP A C     1 
ATOM   1450 O O     . ASP A 1 189 ? -48.23190 24.59500  0.69514   1.000 38.21891 ?  307 ASP A O     1 
ATOM   1451 C CB    . ASP A 1 189 ? -49.15048 27.25632  2.95385   1.000 41.70715 ?  307 ASP A CB    1 
ATOM   1452 C CG    . ASP A 1 189 ? -50.49520 27.41814  2.23468   1.000 44.77579 ?  307 ASP A CG    1 
ATOM   1453 O OD1   . ASP A 1 189 ? -50.89558 26.48317  1.51759   1.000 40.39368 ?  307 ASP A OD1   1 
ATOM   1454 O OD2   . ASP A 1 189 ? -51.17596 28.46421  2.39587   1.000 45.81292 -1 307 ASP A OD2   1 
ATOM   1455 N N     . GLU A 1 190 ? -48.82734 24.36393  2.84924   1.000 39.72998 ?  308 GLU A N     1 
ATOM   1456 C CA    . GLU A 1 190 ? -49.03712 22.92619  2.68520   1.000 38.68016 ?  308 GLU A CA    1 
ATOM   1457 C C     . GLU A 1 190 ? -50.22632 22.60288  1.78696   1.000 37.70547 ?  308 GLU A C     1 
ATOM   1458 O O     . GLU A 1 190 ? -50.43509 21.42759  1.45524   1.000 36.17691 ?  308 GLU A O     1 
ATOM   1459 C CB    . GLU A 1 190 ? -49.24510 22.26182  4.04714   1.000 37.71169 ?  308 GLU A CB    1 
ATOM   1460 C CG    . GLU A 1 190 ? -50.59139 22.56566  4.69975   1.000 38.84421 ?  308 GLU A CG    1 
ATOM   1461 C CD    . GLU A 1 190 ? -50.63700 23.85234  5.52317   1.000 43.56059 ?  308 GLU A CD    1 
ATOM   1462 O OE1   . GLU A 1 190 ? -49.79785 24.74767  5.35287   1.000 45.05612 ?  308 GLU A OE1   1 
ATOM   1463 O OE2   . GLU A 1 190 ? -51.54352 23.95040  6.36051   1.000 50.00328 -1 308 GLU A OE2   1 
ATOM   1464 N N     . LYS A 1 191 ? -51.03580 23.60493  1.41572   1.000 34.42957 ?  309 LYS A N     1 
ATOM   1465 C CA    . LYS A 1 191 ? -52.14797 23.34291  0.51302   1.000 34.08972 ?  309 LYS A CA    1 
ATOM   1466 C C     . LYS A 1 191 ? -51.69122 22.95525  -0.88289  1.000 30.50045 ?  309 LYS A C     1 
ATOM   1467 O O     . LYS A 1 191 ? -52.53492 22.51070  -1.67418  1.000 31.47630 ?  309 LYS A O     1 
ATOM   1468 C CB    . LYS A 1 191 ? -53.07705 24.56240  0.41522   1.000 34.20047 ?  309 LYS A CB    1 
ATOM   1469 C CG    . LYS A 1 191 ? -53.78884 24.91530  1.73142   1.000 33.16735 ?  309 LYS A CG    1 
ATOM   1470 C CD    . LYS A 1 191 ? -54.88402 23.91166  2.05006   1.000 36.27473 ?  309 LYS A CD    1 
ATOM   1471 C CE    . LYS A 1 191 ? -55.70844 24.39250  3.23675   1.000 44.07599 ?  309 LYS A CE    1 
ATOM   1472 N NZ    . LYS A 1 191 ? -56.82024 23.45082  3.53482   1.000 41.94601 ?  309 LYS A NZ    1 
ATOM   1473 N N     . VAL A 1 192 ? -50.40281 23.12249  -1.21191  1.000 31.56713 ?  310 VAL A N     1 
ATOM   1474 C CA    . VAL A 1 192 ? -49.90875 22.61681  -2.49461  1.000 31.66308 ?  310 VAL A CA    1 
ATOM   1475 C C     . VAL A 1 192 ? -50.11118 21.10829  -2.58358  1.000 32.02931 ?  310 VAL A C     1 
ATOM   1476 O O     . VAL A 1 192 ? -50.31532 20.56344  -3.67299  1.000 30.99512 ?  310 VAL A O     1 
ATOM   1477 C CB    . VAL A 1 192 ? -48.43119 22.99611  -2.71870  1.000 35.09792 ?  310 VAL A CB    1 
ATOM   1478 C CG1   . VAL A 1 192 ? -48.23315 24.52156  -2.72272  1.000 36.00924 ?  310 VAL A CG1   1 
ATOM   1479 C CG2   . VAL A 1 192 ? -47.51542 22.35447  -1.67873  1.000 36.68664 ?  310 VAL A CG2   1 
ATOM   1480 N N     . ASP A 1 193 ? -50.06525 20.41193  -1.45066  1.000 32.27321 ?  311 ASP A N     1 
ATOM   1481 C CA    . ASP A 1 193 ? -50.24603 18.96455  -1.48440  1.000 32.59011 ?  311 ASP A CA    1 
ATOM   1482 C C     . ASP A 1 193 ? -51.69525 18.60231  -1.74935  1.000 30.80674 ?  311 ASP A C     1 
ATOM   1483 O O     . ASP A 1 193 ? -51.97430 17.54974  -2.32367  1.000 31.65395 ?  311 ASP A O     1 
ATOM   1484 C CB    . ASP A 1 193 ? -49.75936 18.34085  -0.17778  1.000 33.03001 ?  311 ASP A CB    1 
ATOM   1485 C CG    . ASP A 1 193 ? -48.24640 18.46123  0.00904   1.000 35.37588 ?  311 ASP A CG    1 
ATOM   1486 O OD1   . ASP A 1 193 ? -47.50407 18.35256  -0.98574  1.000 35.84896 ?  311 ASP A OD1   1 
ATOM   1487 O OD2   . ASP A 1 193 ? -47.79855 18.69235  1.15283   1.000 37.28208 -1 311 ASP A OD2   1 
ATOM   1488 N N     . LEU A 1 194 ? -52.63332 19.46780  -1.36160  1.000 31.99061 ?  312 LEU A N     1 
ATOM   1489 C CA    . LEU A 1 194 ? -54.03015 19.19044  -1.65743  1.000 30.98486 ?  312 LEU A CA    1 
ATOM   1490 C C     . LEU A 1 194 ? -54.30594 19.35749  -3.14242  1.000 32.61663 ?  312 LEU A C     1 
ATOM   1491 O O     . LEU A 1 194 ? -55.01416 18.53636  -3.74736  1.000 31.97289 ?  312 LEU A O     1 
ATOM   1492 C CB    . LEU A 1 194 ? -54.93163 20.10565  -0.82510  1.000 32.61370 ?  312 LEU A CB    1 
ATOM   1493 C CG    . LEU A 1 194 ? -55.19517 19.68562  0.63391   1.000 29.65039 ?  312 LEU A CG    1 
ATOM   1494 C CD1   . LEU A 1 194 ? -55.99108 18.39890  0.68343   1.000 32.79122 ?  312 LEU A CD1   1 
ATOM   1495 C CD2   . LEU A 1 194 ? -53.90638 19.59498  1.47536   1.000 33.71326 ?  312 LEU A CD2   1 
ATOM   1496 N N     . TRP A 1 195 ? -53.74637 20.41111  -3.74204  1.000 28.84357 ?  313 TRP A N     1 
ATOM   1497 C CA    . TRP A 1 195 ? -53.79281 20.56887  -5.19145  1.000 29.66469 ?  313 TRP A CA    1 
ATOM   1498 C C     . TRP A 1 195 ? -53.25976 19.32630  -5.90505  1.000 31.86536 ?  313 TRP A C     1 
ATOM   1499 O O     . TRP A 1 195 ? -53.90578 18.79708  -6.81751  1.000 31.27183 ?  313 TRP A O     1 
ATOM   1500 C CB    . TRP A 1 195 ? -52.98600 21.80191  -5.60892  1.000 31.39097 ?  313 TRP A CB    1 
ATOM   1501 C CG    . TRP A 1 195 ? -52.89240 21.93458  -7.12479  1.000 30.07951 ?  313 TRP A CG    1 
ATOM   1502 C CD1   . TRP A 1 195 ? -51.93413 21.37321  -7.94643  1.000 33.26184 ?  313 TRP A CD1   1 
ATOM   1503 C CD2   . TRP A 1 195 ? -53.78593 22.65434  -7.98779  1.000 32.18514 ?  313 TRP A CD2   1 
ATOM   1504 N NE1   . TRP A 1 195 ? -52.18388 21.71003  -9.26206  1.000 31.36319 ?  313 TRP A NE1   1 
ATOM   1505 C CE2   . TRP A 1 195 ? -53.30400 22.49778  -9.31881  1.000 30.64124 ?  313 TRP A CE2   1 
ATOM   1506 C CE3   . TRP A 1 195 ? -54.94279 23.42005  -7.77368  1.000 30.95576 ?  313 TRP A CE3   1 
ATOM   1507 C CZ2   . TRP A 1 195 ? -53.94452 23.06925  -10.41570 1.000 29.77512 ?  313 TRP A CZ2   1 
ATOM   1508 C CZ3   . TRP A 1 195 ? -55.57118 23.99342  -8.87156  1.000 31.20614 ?  313 TRP A CZ3   1 
ATOM   1509 C CH2   . TRP A 1 195 ? -55.06986 23.81411  -10.17803 1.000 31.08543 ?  313 TRP A CH2   1 
ATOM   1510 N N     . SER A 1 196 ? -52.06705 18.86324  -5.50981  1.000 30.28219 ?  314 SER A N     1 
ATOM   1511 C CA    . SER A 1 196 ? -51.46691 17.68731  -6.14222  1.000 31.97011 ?  314 SER A CA    1 
ATOM   1512 C C     . SER A 1 196 ? -52.36380 16.46128  -6.02146  1.000 31.03576 ?  314 SER A C     1 
ATOM   1513 O O     . SER A 1 196 ? -52.43987 15.64757  -6.95274  1.000 27.76630 ?  314 SER A O     1 
ATOM   1514 C CB    . SER A 1 196 ? -50.09944 17.38976  -5.52522  1.000 33.00045 ?  314 SER A CB    1 
ATOM   1515 O OG    . SER A 1 196 ? -49.17458 18.43519  -5.75915  1.000 35.90833 ?  314 SER A OG    1 
ATOM   1516 N N     . LEU A 1 197 ? -53.03830 16.29990  -4.87865  1.000 29.77922 ?  315 LEU A N     1 
ATOM   1517 C CA    . LEU A 1 197 ? -53.95047 15.16884  -4.70375  1.000 31.55324 ?  315 LEU A CA    1 
ATOM   1518 C C     . LEU A 1 197 ? -55.09988 15.23420  -5.69544  1.000 32.11606 ?  315 LEU A C     1 
ATOM   1519 O O     . LEU A 1 197 ? -55.55133 14.20154  -6.19799  1.000 29.48909 ?  315 LEU A O     1 
ATOM   1520 C CB    . LEU A 1 197 ? -54.51628 15.12538  -3.28508  1.000 32.52105 ?  315 LEU A CB    1 
ATOM   1521 C CG    . LEU A 1 197 ? -53.92108 14.27908  -2.16490  1.000 43.26523 ?  315 LEU A CG    1 
ATOM   1522 C CD1   . LEU A 1 197 ? -54.90246 14.24033  -0.99590  1.000 39.51867 ?  315 LEU A CD1   1 
ATOM   1523 C CD2   . LEU A 1 197 ? -53.56128 12.85255  -2.60576  1.000 32.81503 ?  315 LEU A CD2   1 
ATOM   1524 N N     . GLY A 1 198 ? -55.59523 16.43856  -5.98023  1.000 29.76108 ?  316 GLY A N     1 
ATOM   1525 C CA    . GLY A 1 198 ? -56.65465 16.57117  -6.96800  1.000 26.90999 ?  316 GLY A CA    1 
ATOM   1526 C C     . GLY A 1 198 ? -56.19505 16.23573  -8.37414  1.000 28.16420 ?  316 GLY A C     1 
ATOM   1527 O O     . GLY A 1 198 ? -56.94019 15.61758  -9.14272  1.000 29.27955 ?  316 GLY A O     1 
ATOM   1528 N N     . VAL A 1 199 ? -54.98786 16.67848  -8.75377  1.000 27.17951 ?  317 VAL A N     1 
ATOM   1529 C CA    . VAL A 1 199 ? -54.44817 16.32979  -10.07813 1.000 29.46819 ?  317 VAL A CA    1 
ATOM   1530 C C     . VAL A 1 199 ? -54.29609 14.82119  -10.19513 1.000 28.13751 ?  317 VAL A C     1 
ATOM   1531 O O     . VAL A 1 199 ? -54.55562 14.22887  -11.25387 1.000 28.81176 ?  317 VAL A O     1 
ATOM   1532 C CB    . VAL A 1 199 ? -53.08817 17.00959  -10.33348 1.000 28.74922 ?  317 VAL A CB    1 
ATOM   1533 C CG1   . VAL A 1 199 ? -52.53890 16.58397  -11.72286 1.000 29.34735 ?  317 VAL A CG1   1 
ATOM   1534 C CG2   . VAL A 1 199 ? -53.19506 18.53779  -10.24644 1.000 29.92135 ?  317 VAL A CG2   1 
ATOM   1535 N N     . LEU A 1 200 ? -53.82568 14.19038  -9.12123  1.000 26.67642 ?  318 LEU A N     1 
ATOM   1536 C CA    . LEU A 1 200 ? -53.60439 12.74151  -9.10765  1.000 25.82511 ?  318 LEU A CA    1 
ATOM   1537 C C     . LEU A 1 200 ? -54.91592 11.97192  -9.18510  1.000 29.17536 ?  318 LEU A C     1 
ATOM   1538 O O     . LEU A 1 200 ? -55.03241 10.98087  -9.92898  1.000 30.31133 ?  318 LEU A O     1 
ATOM   1539 C CB    . LEU A 1 200 ? -52.84783 12.35425  -7.82347  1.000 27.41125 ?  318 LEU A CB    1 
ATOM   1540 C CG    . LEU A 1 200 ? -52.17175 10.99069  -7.80922  1.000 33.86868 ?  318 LEU A CG    1 
ATOM   1541 C CD1   . LEU A 1 200 ? -51.04891 10.83108  -8.86617  1.000 30.58818 ?  318 LEU A CD1   1 
ATOM   1542 C CD2   . LEU A 1 200 ? -51.64238 10.74742  -6.41822  1.000 34.41461 ?  318 LEU A CD2   1 
ATOM   1543 N N     . CYS A 1 201 ? -55.90552 12.37660  -8.38625  1.000 27.93719 ?  319 CYS A N     1 
ATOM   1544 C CA    . CYS A 1 201 ? -57.20636 11.71462  -8.44350  1.000 28.45190 ?  319 CYS A CA    1 
ATOM   1545 C C     . CYS A 1 201 ? -57.77413 11.76580  -9.85258  1.000 31.67584 ?  319 CYS A C     1 
ATOM   1546 O O     . CYS A 1 201 ? -58.31322 10.76863  -10.36332 1.000 30.72005 ?  319 CYS A O     1 
ATOM   1547 C CB    . CYS A 1 201 ? -58.16281 12.37580  -7.44654  1.000 30.87330 ?  319 CYS A CB    1 
ATOM   1548 S SG    . CYS A 1 201 ? -59.68549 11.45296  -7.15322  1.000 35.98047 ?  319 CYS A SG    1 
ATOM   1549 N N     . TYR A 1 202 ? -57.66184 12.92025  -10.50819 1.000 28.24019 ?  320 TYR A N     1 
ATOM   1550 C CA    . TYR A 1 202 ? -58.12280 13.02195  -11.88726 1.000 27.54033 ?  320 TYR A CA    1 
ATOM   1551 C C     . TYR A 1 202 ? -57.30339 12.11334  -12.81242 1.000 30.50762 ?  320 TYR A C     1 
ATOM   1552 O O     . TYR A 1 202 ? -57.86599 11.37703  -13.63213 1.000 30.94856 ?  320 TYR A O     1 
ATOM   1553 C CB    . TYR A 1 202 ? -58.03600 14.47872  -12.34536 1.000 31.17304 ?  320 TYR A CB    1 
ATOM   1554 C CG    . TYR A 1 202 ? -58.55443 14.74079  -13.75365 1.000 30.68199 ?  320 TYR A CG    1 
ATOM   1555 C CD1   . TYR A 1 202 ? -57.80755 14.37762  -14.87000 1.000 30.14320 ?  320 TYR A CD1   1 
ATOM   1556 C CD2   . TYR A 1 202 ? -59.75905 15.41717  -13.95673 1.000 31.90045 ?  320 TYR A CD2   1 
ATOM   1557 C CE1   . TYR A 1 202 ? -58.24802 14.64535  -16.15340 1.000 32.76303 ?  320 TYR A CE1   1 
ATOM   1558 C CE2   . TYR A 1 202 ? -60.21625 15.69164  -15.24849 1.000 32.80370 ?  320 TYR A CE2   1 
ATOM   1559 C CZ    . TYR A 1 202 ? -59.45746 15.30046  -16.33914 1.000 33.20067 ?  320 TYR A CZ    1 
ATOM   1560 O OH    . TYR A 1 202 ? -59.88119 15.58071  -17.62061 1.000 32.76570 ?  320 TYR A OH    1 
ATOM   1561 N N     . GLU A 1 203 ? -55.97121 12.18522  -12.73582 1.000 29.73811 ?  321 GLU A N     1 
ATOM   1562 C CA    . GLU A 1 203 ? -55.16463 11.32499  -13.60905 1.000 27.07649 ?  321 GLU A CA    1 
ATOM   1563 C C     . GLU A 1 203 ? -55.48451 9.84272   -13.38024 1.000 30.82423 ?  321 GLU A C     1 
ATOM   1564 O O     . GLU A 1 203 ? -55.56275 9.06107   -14.34072 1.000 33.09524 ?  321 GLU A O     1 
ATOM   1565 C CB    . GLU A 1 203 ? -53.67531 11.59397  -13.41918 1.000 31.81533 ?  321 GLU A CB    1 
ATOM   1566 C CG    . GLU A 1 203 ? -52.82826 10.71344  -14.37089 1.000 32.44857 ?  321 GLU A CG    1 
ATOM   1567 C CD    . GLU A 1 203 ? -51.45643 11.25674  -14.71354 1.000 35.67398 ?  321 GLU A CD    1 
ATOM   1568 O OE1   . GLU A 1 203 ? -50.84433 12.01136  -13.92395 1.000 33.96509 ?  321 GLU A OE1   1 
ATOM   1569 O OE2   . GLU A 1 203 ? -50.97888 10.89305  -15.81062 1.000 40.35942 -1 321 GLU A OE2   1 
ATOM   1570 N N     . PHE A 1 204 ? -55.68997 9.44296   -12.12205 1.000 29.57766 ?  322 PHE A N     1 
ATOM   1571 C CA    . PHE A 1 204 ? -56.04165 8.05240   -11.81846 1.000 30.59740 ?  322 PHE A CA    1 
ATOM   1572 C C     . PHE A 1 204 ? -57.31813 7.63926   -12.54865 1.000 34.86986 ?  322 PHE A C     1 
ATOM   1573 O O     . PHE A 1 204 ? -57.39898 6.53974   -13.11905 1.000 33.06828 ?  322 PHE A O     1 
ATOM   1574 C CB    . PHE A 1 204 ? -56.22177 7.87148   -10.30305 1.000 29.70592 ?  322 PHE A CB    1 
ATOM   1575 C CG    . PHE A 1 204 ? -54.92790 7.75746   -9.51304  1.000 30.01461 ?  322 PHE A CG    1 
ATOM   1576 C CD1   . PHE A 1 204 ? -53.71486 7.67055   -10.13760 1.000 32.72908 ?  322 PHE A CD1   1 
ATOM   1577 C CD2   . PHE A 1 204 ? -54.95859 7.72656   -8.12344  1.000 30.23133 ?  322 PHE A CD2   1 
ATOM   1578 C CE1   . PHE A 1 204 ? -52.51463 7.54951   -9.38767  1.000 32.51052 ?  322 PHE A CE1   1 
ATOM   1579 C CE2   . PHE A 1 204 ? -53.79938 7.61547   -7.37825  1.000 30.71370 ?  322 PHE A CE2   1 
ATOM   1580 C CZ    . PHE A 1 204 ? -52.56723 7.52377   -8.01895  1.000 30.29652 ?  322 PHE A CZ    1 
ATOM   1581 N N     . LEU A 1 205 ? -58.35047 8.49817   -12.50593 1.000 31.42426 ?  323 LEU A N     1 
ATOM   1582 C CA    . LEU A 1 205 ? -59.65621 8.12191   -13.04597 1.000 34.02495 ?  323 LEU A CA    1 
ATOM   1583 C C     . LEU A 1 205 ? -59.73269 8.27665   -14.55279 1.000 34.37657 ?  323 LEU A C     1 
ATOM   1584 O O     . LEU A 1 205 ? -60.50457 7.55769   -15.20920 1.000 35.11365 ?  323 LEU A O     1 
ATOM   1585 C CB    . LEU A 1 205 ? -60.76597 8.96665   -12.40143 1.000 33.77205 ?  323 LEU A CB    1 
ATOM   1586 C CG    . LEU A 1 205 ? -60.98523 8.74916   -10.89764 1.000 32.25089 ?  323 LEU A CG    1 
ATOM   1587 C CD1   . LEU A 1 205 ? -61.94075 9.80656   -10.34680 1.000 33.93765 ?  323 LEU A CD1   1 
ATOM   1588 C CD2   . LEU A 1 205 ? -61.52201 7.34411   -10.63080 1.000 35.74989 ?  323 LEU A CD2   1 
ATOM   1589 N N     . VAL A 1 206 ? -58.96377 9.20948   -15.11123 1.000 31.92814 ?  324 VAL A N     1 
ATOM   1590 C CA    . VAL A 1 206 ? -59.07137 9.59739   -16.51838 1.000 33.44776 ?  324 VAL A CA    1 
ATOM   1591 C C     . VAL A 1 206 ? -57.97448 8.95315   -17.35709 1.000 34.64071 ?  324 VAL A C     1 
ATOM   1592 O O     . VAL A 1 206 ? -58.17088 8.65964   -18.54523 1.000 34.55599 ?  324 VAL A O     1 
ATOM   1593 C CB    . VAL A 1 206 ? -59.02969 11.13303  -16.64583 1.000 33.77546 ?  324 VAL A CB    1 
ATOM   1594 C CG1   . VAL A 1 206 ? -59.03829 11.55842  -18.11398 1.000 33.75088 ?  324 VAL A CG1   1 
ATOM   1595 C CG2   . VAL A 1 206 ? -60.25737 11.73981  -15.90631 1.000 32.83998 ?  324 VAL A CG2   1 
ATOM   1596 N N     . GLY A 1 207 ? -56.80702 8.75514   -16.76041 1.000 32.32597 ?  325 GLY A N     1 
ATOM   1597 C CA    . GLY A 1 207 ? -55.66217 8.27920   -17.51141 1.000 36.53872 ?  325 GLY A CA    1 
ATOM   1598 C C     . GLY A 1 207 ? -54.76896 9.35247   -18.09453 1.000 37.51082 ?  325 GLY A C     1 
ATOM   1599 O O     . GLY A 1 207 ? -53.74420 9.01682   -18.70701 1.000 36.20225 ?  325 GLY A O     1 
ATOM   1600 N N     . LYS A 1 208 ? -55.10979 10.62745  -17.91983 1.000 32.35336 ?  326 LYS A N     1 
ATOM   1601 C CA    . LYS A 1 208 ? -54.32832 11.76994  -18.37695 1.000 34.29663 ?  326 LYS A CA    1 
ATOM   1602 C C     . LYS A 1 208 ? -54.42789 12.82877  -17.29272 1.000 32.35060 ?  326 LYS A C     1 
ATOM   1603 O O     . LYS A 1 208 ? -55.46656 12.92831  -16.63385 1.000 31.63821 ?  326 LYS A O     1 
ATOM   1604 C CB    . LYS A 1 208 ? -54.88998 12.38875  -19.67106 1.000 37.41632 ?  326 LYS A CB    1 
ATOM   1605 C CG    . LYS A 1 208 ? -54.89202 11.52592  -20.90651 1.000 45.47838 ?  326 LYS A CG    1 
ATOM   1606 C CD    . LYS A 1 208 ? -55.82326 12.16409  -21.93442 1.000 43.48823 ?  326 LYS A CD    1 
ATOM   1607 N N     . PRO A 1 209 ? -53.39805 13.65598  -17.10930 1.000 33.11535 ?  327 PRO A N     1 
ATOM   1608 C CA    . PRO A 1 209 ? -53.51203 14.73163  -16.12931 1.000 34.04484 ?  327 PRO A CA    1 
ATOM   1609 C C     . PRO A 1 209 ? -54.38918 15.84739  -16.66950 1.000 35.41225 ?  327 PRO A C     1 
ATOM   1610 O O     . PRO A 1 209 ? -54.44415 16.08169  -17.89085 1.000 31.13056 ?  327 PRO A O     1 
ATOM   1611 C CB    . PRO A 1 209 ? -52.05443 15.18718  -15.93275 1.000 38.20331 ?  327 PRO A CB    1 
ATOM   1612 C CG    . PRO A 1 209 ? -51.39748 14.87953  -17.23069 1.000 38.73165 ?  327 PRO A CG    1 
ATOM   1613 C CD    . PRO A 1 209 ? -52.07125 13.63254  -17.75386 1.000 37.01124 ?  327 PRO A CD    1 
ATOM   1614 N N     . PRO A 1 210 ? -55.09623 16.57034  -15.79192 1.000 31.51941 ?  328 PRO A N     1 
ATOM   1615 C CA    . PRO A 1 210 ? -56.15860 17.48191  -16.25867 1.000 31.65077 ?  328 PRO A CA    1 
ATOM   1616 C C     . PRO A 1 210 ? -55.69936 18.69008  -17.07544 1.000 33.70308 ?  328 PRO A C     1 
ATOM   1617 O O     . PRO A 1 210 ? -56.51692 19.22687  -17.84163 1.000 33.09826 ?  328 PRO A O     1 
ATOM   1618 C CB    . PRO A 1 210 ? -56.83485 17.94513  -14.95339 1.000 33.44895 ?  328 PRO A CB    1 
ATOM   1619 C CG    . PRO A 1 210 ? -55.90127 17.54153  -13.81630 1.000 31.97652 ?  328 PRO A CG    1 
ATOM   1620 C CD    . PRO A 1 210 ? -55.00787 16.45215  -14.32418 1.000 30.79775 ?  328 PRO A CD    1 
ATOM   1621 N N     . PHE A 1 211 ? -54.46013 19.17944  -16.91500 1.000 31.28949 ?  329 PHE A N     1 
ATOM   1622 C CA    . PHE A 1 211 ? -54.04848 20.42695  -17.55923 1.000 32.15633 ?  329 PHE A CA    1 
ATOM   1623 C C     . PHE A 1 211 ? -53.06839 20.19200  -18.69138 1.000 39.26623 ?  329 PHE A C     1 
ATOM   1624 O O     . PHE A 1 211 ? -52.41006 21.12700  -19.15323 1.000 36.65377 ?  329 PHE A O     1 
ATOM   1625 C CB    . PHE A 1 211 ? -53.46793 21.39198  -16.52913 1.000 32.31180 ?  329 PHE A CB    1 
ATOM   1626 C CG    . PHE A 1 211 ? -54.37604 21.60401  -15.36855 1.000 32.70817 ?  329 PHE A CG    1 
ATOM   1627 C CD1   . PHE A 1 211 ? -55.55920 22.32318  -15.52984 1.000 33.17848 ?  329 PHE A CD1   1 
ATOM   1628 C CD2   . PHE A 1 211 ? -54.08665 21.04861  -14.13508 1.000 29.79968 ?  329 PHE A CD2   1 
ATOM   1629 C CE1   . PHE A 1 211 ? -56.43055 22.50643  -14.47572 1.000 29.96758 ?  329 PHE A CE1   1 
ATOM   1630 C CE2   . PHE A 1 211 ? -54.97696 21.21491  -13.06182 1.000 32.50126 ?  329 PHE A CE2   1 
ATOM   1631 C CZ    . PHE A 1 211 ? -56.14269 21.96526  -13.23814 1.000 30.52760 ?  329 PHE A CZ    1 
ATOM   1632 N N     . GLU A 1 212 ? -52.98771 18.95384  -19.15614 1.000 39.43466 ?  330 GLU A N     1 
ATOM   1633 C CA    . GLU A 1 212 ? -52.07767 18.58909  -20.22487 1.000 45.93636 ?  330 GLU A CA    1 
ATOM   1634 C C     . GLU A 1 212 ? -52.37054 19.42677  -21.45624 1.000 42.58753 ?  330 GLU A C     1 
ATOM   1635 O O     . GLU A 1 212 ? -53.53277 19.62818  -21.81723 1.000 42.55603 ?  330 GLU A O     1 
ATOM   1636 C CB    . GLU A 1 212 ? -52.25217 17.09795  -20.51700 1.000 44.51492 ?  330 GLU A CB    1 
ATOM   1637 C CG    . GLU A 1 212 ? -51.26531 16.51935  -21.44675 1.000 48.40875 ?  330 GLU A CG    1 
ATOM   1638 C CD    . GLU A 1 212 ? -51.36232 15.01729  -21.46131 1.000 45.58312 ?  330 GLU A CD    1 
ATOM   1639 O OE1   . GLU A 1 212 ? -52.38219 14.47235  -21.95435 1.000 45.25590 ?  330 GLU A OE1   1 
ATOM   1640 O OE2   . GLU A 1 212 ? -50.43569 14.39377  -20.90594 1.000 48.78430 -1 330 GLU A OE2   1 
ATOM   1641 N N     . ALA A 1 213 ? -51.31390 19.95146  -22.07501 1.000 43.46198 ?  331 ALA A N     1 
ATOM   1642 C CA    . ALA A 1 213 ? -51.43128 20.74138  -23.28956 1.000 47.28857 ?  331 ALA A CA    1 
ATOM   1643 C C     . ALA A 1 213 ? -50.23183 20.44578  -24.18336 1.000 51.51194 ?  331 ALA A C     1 
ATOM   1644 O O     . ALA A 1 213 ? -49.26857 19.78773  -23.77357 1.000 50.80621 ?  331 ALA A O     1 
ATOM   1645 C CB    . ALA A 1 213 ? -51.54025 22.23950  -22.98694 1.000 45.41479 ?  331 ALA A CB    1 
ATOM   1646 N N     . ASN A 1 214 ? -50.30288 20.93025  -25.42516 1.000 51.33746 ?  332 ASN A N     1 
ATOM   1647 C CA    . ASN A 1 214 ? -49.24829 20.64137  -26.39647 1.000 54.10249 ?  332 ASN A CA    1 
ATOM   1648 C C     . ASN A 1 214 ? -47.90857 21.19636  -25.94270 1.000 51.36421 ?  332 ASN A C     1 
ATOM   1649 O O     . ASN A 1 214 ? -46.85968 20.57324  -26.16471 1.000 51.90333 ?  332 ASN A O     1 
ATOM   1650 C CB    . ASN A 1 214 ? -49.60769 21.22622  -27.76007 1.000 55.74206 ?  332 ASN A CB    1 
ATOM   1651 C CG    . ASN A 1 214 ? -51.04293 20.97410  -28.14234 1.000 62.96446 ?  332 ASN A CG    1 
ATOM   1652 O OD1   . ASN A 1 214 ? -51.32201 20.11456  -28.97687 1.000 66.55231 ?  332 ASN A OD1   1 
ATOM   1653 N ND2   . ASN A 1 214 ? -51.96792 21.73103  -27.54736 1.000 64.79421 ?  332 ASN A ND2   1 
ATOM   1654 N N     . THR A 1 215 ? -47.92650 22.37169  -25.31238 1.000 46.18650 ?  333 THR A N     1 
ATOM   1655 C CA    . THR A 1 215 ? -46.73506 23.10983  -24.92684 1.000 46.51166 ?  333 THR A CA    1 
ATOM   1656 C C     . THR A 1 215 ? -46.75612 23.40480  -23.43199 1.000 47.53011 ?  333 THR A C     1 
ATOM   1657 O O     . THR A 1 215 ? -47.82317 23.47819  -22.81251 1.000 44.64445 ?  333 THR A O     1 
ATOM   1658 C CB    . THR A 1 215 ? -46.62675 24.43232  -25.70016 1.000 46.13201 ?  333 THR A CB    1 
ATOM   1659 O OG1   . THR A 1 215 ? -47.56202 25.37933  -25.17193 1.000 45.28451 ?  333 THR A OG1   1 
ATOM   1660 C CG2   . THR A 1 215 ? -46.92960 24.22462  -27.19475 1.000 49.23869 ?  333 THR A CG2   1 
ATOM   1661 N N     . TYR A 1 216 ? -45.55989 23.58442  -22.86185 1.000 44.19600 ?  334 TYR A N     1 
ATOM   1662 C CA    . TYR A 1 216 ? -45.45289 23.98849  -21.46145 1.000 47.30287 ?  334 TYR A CA    1 
ATOM   1663 C C     . TYR A 1 216 ? -46.15116 25.32572  -21.22867 1.000 47.93444 ?  334 TYR A C     1 
ATOM   1664 O O     . TYR A 1 216 ? -46.81838 25.52108  -20.20201 1.000 44.24590 ?  334 TYR A O     1 
ATOM   1665 C CB    . TYR A 1 216 ? -43.97514 24.07508  -21.05273 1.000 48.03502 ?  334 TYR A CB    1 
ATOM   1666 C CG    . TYR A 1 216 ? -43.27255 22.73596  -20.90313 1.000 46.49070 ?  334 TYR A CG    1 
ATOM   1667 C CD1   . TYR A 1 216 ? -43.91188 21.54731  -21.23479 1.000 50.45972 ?  334 TYR A CD1   1 
ATOM   1668 C CD2   . TYR A 1 216 ? -41.95014 22.66696  -20.47421 1.000 47.74550 ?  334 TYR A CD2   1 
ATOM   1669 C CE1   . TYR A 1 216 ? -43.26365 20.31555  -21.11316 1.000 48.28546 ?  334 TYR A CE1   1 
ATOM   1670 C CE2   . TYR A 1 216 ? -41.29059 21.44465  -20.35681 1.000 48.11539 ?  334 TYR A CE2   1 
ATOM   1671 C CZ    . TYR A 1 216 ? -41.95341 20.27330  -20.67443 1.000 47.39256 ?  334 TYR A CZ    1 
ATOM   1672 O OH    . TYR A 1 216 ? -41.29761 19.04987  -20.56475 1.000 49.26607 ?  334 TYR A OH    1 
ATOM   1673 N N     . GLN A 1 217 ? -46.02601 26.25104  -22.18871 1.000 47.00707 ?  335 GLN A N     1 
ATOM   1674 C CA    A GLN A 1 217 ? -46.60855 27.57918  -22.02568 0.000 43.87942 ?  335 GLN A CA    1 
ATOM   1675 C CA    B GLN A 1 217 ? -46.60880 27.57866  -22.02538 1.000 43.53578 ?  335 GLN A CA    1 
ATOM   1676 C C     . GLN A 1 217 ? -48.12264 27.50553  -21.88418 1.000 43.37213 ?  335 GLN A C     1 
ATOM   1677 O O     . GLN A 1 217 ? -48.70307 28.16612  -21.01686 1.000 42.48084 ?  335 GLN A O     1 
ATOM   1678 C CB    A GLN A 1 217 ? -46.22113 28.47132  -23.20584 0.000 44.01010 ?  335 GLN A CB    1 
ATOM   1679 C CB    B GLN A 1 217 ? -46.23229 28.47329  -23.20800 1.000 44.87131 ?  335 GLN A CB    1 
ATOM   1680 N N     . GLU A 1 218 ? -48.78095 26.71174  -22.73325 1.000 44.40341 ?  336 GLU A N     1 
ATOM   1681 C CA    . GLU A 1 218 ? -50.22634 26.56779  -22.61990 1.000 42.32780 ?  336 GLU A CA    1 
ATOM   1682 C C     . GLU A 1 218 ? -50.58969 25.87068  -21.31957 1.000 41.41487 ?  336 GLU A C     1 
ATOM   1683 O O     . GLU A 1 218 ? -51.62427 26.18369  -20.71579 1.000 39.09767 ?  336 GLU A O     1 
ATOM   1684 C CB    . GLU A 1 218 ? -50.78914 25.79539  -23.82245 1.000 42.07181 ?  336 GLU A CB    1 
ATOM   1685 N N     . THR A 1 219 ? -49.74382 24.94319  -20.86083 1.000 37.84950 ?  337 THR A N     1 
ATOM   1686 C CA    . THR A 1 219 ? -50.04588 24.24916  -19.61191 1.000 37.09404 ?  337 THR A CA    1 
ATOM   1687 C C     . THR A 1 219 ? -50.06256 25.22707  -18.44458 1.000 35.94686 ?  337 THR A C     1 
ATOM   1688 O O     . THR A 1 219 ? -50.92988 25.13076  -17.56509 1.000 35.29200 ?  337 THR A O     1 
ATOM   1689 C CB    . THR A 1 219 ? -49.04876 23.11359  -19.37160 1.000 39.12407 ?  337 THR A CB    1 
ATOM   1690 O OG1   . THR A 1 219 ? -49.19152 22.12603  -20.39898 1.000 42.64253 ?  337 THR A OG1   1 
ATOM   1691 C CG2   . THR A 1 219 ? -49.29890 22.44451  -18.01764 1.000 36.87392 ?  337 THR A CG2   1 
ATOM   1692 N N     . TYR A 1 220 ? -49.12634 26.18746  -18.43945 1.000 37.05685 ?  338 TYR A N     1 
ATOM   1693 C CA    . TYR A 1 220 ? -49.10519 27.25619  -17.43855 1.000 37.45220 ?  338 TYR A CA    1 
ATOM   1694 C C     . TYR A 1 220 ? -50.43918 27.97584  -17.36681 1.000 35.06125 ?  338 TYR A C     1 
ATOM   1695 O O     . TYR A 1 220 ? -50.98858 28.18290  -16.28085 1.000 34.25045 ?  338 TYR A O     1 
ATOM   1696 C CB    . TYR A 1 220 ? -48.03004 28.28368  -17.77437 1.000 39.18784 ?  338 TYR A CB    1 
ATOM   1697 C CG    . TYR A 1 220 ? -46.61524 27.83690  -17.57805 1.000 45.81178 ?  338 TYR A CG    1 
ATOM   1698 C CD1   . TYR A 1 220 ? -46.30798 26.77761  -16.74760 1.000 44.89926 ?  338 TYR A CD1   1 
ATOM   1699 C CD2   . TYR A 1 220 ? -45.58131 28.45566  -18.27229 1.000 48.88020 ?  338 TYR A CD2   1 
ATOM   1700 C CE1   . TYR A 1 220 ? -44.99408 26.35913  -16.58133 1.000 50.88613 ?  338 TYR A CE1   1 
ATOM   1701 C CE2   . TYR A 1 220 ? -44.26873 28.03374  -18.12070 1.000 53.61901 ?  338 TYR A CE2   1 
ATOM   1702 C CZ    . TYR A 1 220 ? -43.98669 26.98778  -17.27407 1.000 52.90199 ?  338 TYR A CZ    1 
ATOM   1703 O OH    . TYR A 1 220 ? -42.68739 26.56959  -17.11048 1.000 60.53825 ?  338 TYR A OH    1 
ATOM   1704 N N     . LYS A 1 221 ? -50.93103 28.43063  -18.52205 1.000 33.89928 ?  339 LYS A N     1 
ATOM   1705 C CA    . LYS A 1 221 ? -52.21658 29.11641  -18.56867 1.000 35.34998 ?  339 LYS A CA    1 
ATOM   1706 C C     . LYS A 1 221 ? -53.32980 28.22512  -18.04459 1.000 31.95231 ?  339 LYS A C     1 
ATOM   1707 O O     . LYS A 1 221 ? -54.21425 28.69269  -17.31931 1.000 35.10884 ?  339 LYS A O     1 
ATOM   1708 C CB    . LYS A 1 221 ? -52.52642 29.54810  -20.00370 1.000 36.71690 ?  339 LYS A CB    1 
ATOM   1709 N N     . ARG A 1 222 ? -53.32850 26.93969  -18.42613 1.000 32.83955 ?  340 ARG A N     1 
ATOM   1710 C CA    . ARG A 1 222 ? -54.42346 26.07116  -18.00772 1.000 33.02798 ?  340 ARG A CA    1 
ATOM   1711 C C     . ARG A 1 222 ? -54.41666 25.86233  -16.50530 1.000 33.01343 ?  340 ARG A C     1 
ATOM   1712 O O     . ARG A 1 222 ? -55.47836 25.85821  -15.86922 1.000 32.31391 ?  340 ARG A O     1 
ATOM   1713 C CB    . ARG A 1 222 ? -54.36216 24.72194  -18.71838 1.000 37.84698 ?  340 ARG A CB    1 
ATOM   1714 C CG    . ARG A 1 222 ? -54.38222 24.80549  -20.23091 1.000 40.98951 ?  340 ARG A CG    1 
ATOM   1715 C CD    . ARG A 1 222 ? -55.74552 24.48910  -20.80241 1.000 50.32700 ?  340 ARG A CD    1 
ATOM   1716 N NE    . ARG A 1 222 ? -55.68300 24.40566  -22.25841 1.000 53.22175 ?  340 ARG A NE    1 
ATOM   1717 C CZ    . ARG A 1 222 ? -55.50812 23.27921  -22.93852 1.000 56.19934 ?  340 ARG A CZ    1 
ATOM   1718 N NH1   . ARG A 1 222 ? -55.43191 22.10389  -22.32786 1.000 53.68099 ?  340 ARG A NH1   1 
ATOM   1719 N NH2   . ARG A 1 222 ? -55.42860 23.32895  -24.26545 1.000 59.44101 ?  340 ARG A NH2   1 
ATOM   1720 N N     . ILE A 1 223 ? -53.23338 25.67304  -15.91812 1.000 30.66483 ?  341 ILE A N     1 
ATOM   1721 C CA    . ILE A 1 223 ? -53.14872 25.55176  -14.46549 1.000 30.24999 ?  341 ILE A CA    1 
ATOM   1722 C C     . ILE A 1 223 ? -53.61900 26.83635  -13.78744 1.000 32.57081 ?  341 ILE A C     1 
ATOM   1723 O O     . ILE A 1 223 ? -54.49451 26.80958  -12.90997 1.000 29.93311 ?  341 ILE A O     1 
ATOM   1724 C CB    . ILE A 1 223 ? -51.71576 25.18404  -14.04448 1.000 29.06024 ?  341 ILE A CB    1 
ATOM   1725 C CG1   . ILE A 1 223 ? -51.36165 23.80670  -14.64167 1.000 30.26213 ?  341 ILE A CG1   1 
ATOM   1726 C CG2   . ILE A 1 223 ? -51.61480 25.22291  -12.49538 1.000 32.06788 ?  341 ILE A CG2   1 
ATOM   1727 C CD1   . ILE A 1 223 ? -49.90999 23.37637  -14.37070 1.000 34.33738 ?  341 ILE A CD1   1 
ATOM   1728 N N     . SER A 1 224 ? -53.03000 27.97210  -14.18390 1.000 30.52647 ?  342 SER A N     1 
ATOM   1729 C CA    . SER A 1 224 ? -53.32308 29.25604  -13.55323 1.000 33.24953 ?  342 SER A CA    1 
ATOM   1730 C C     . SER A 1 224 ? -54.80747 29.60199  -13.64075 1.000 33.64031 ?  342 SER A C     1 
ATOM   1731 O O     . SER A 1 224 ? -55.37530 30.16602  -12.70239 1.000 37.79716 ?  342 SER A O     1 
ATOM   1732 C CB    . SER A 1 224 ? -52.46900 30.34625  -14.20737 1.000 40.15720 ?  342 SER A CB    1 
ATOM   1733 O OG    . SER A 1 224 ? -52.61229 31.58144  -13.53769 1.000 45.84552 ?  342 SER A OG    1 
ATOM   1734 N N     . ARG A 1 225 ? -55.45517 29.27046  -14.75438 1.000 33.49347 ?  343 ARG A N     1 
ATOM   1735 C CA    . ARG A 1 225 ? -56.87691 29.54600  -14.93896 1.000 35.14082 ?  343 ARG A CA    1 
ATOM   1736 C C     . ARG A 1 225 ? -57.76412 28.37499  -14.52821 1.000 36.01039 ?  343 ARG A C     1 
ATOM   1737 O O     . ARG A 1 225 ? -58.98412 28.44707  -14.70783 1.000 34.67802 ?  343 ARG A O     1 
ATOM   1738 C CB    . ARG A 1 225 ? -57.14192 29.93082  -16.39533 1.000 35.07451 ?  343 ARG A CB    1 
ATOM   1739 C CG    . ARG A 1 225 ? -56.25572 31.06168  -16.87131 1.000 38.72870 ?  343 ARG A CG    1 
ATOM   1740 C CD    . ARG A 1 225 ? -56.39823 31.34245  -18.36545 1.000 38.25195 ?  343 ARG A CD    1 
ATOM   1741 N NE    . ARG A 1 225 ? -55.52430 32.45116  -18.72066 1.000 41.47969 ?  343 ARG A NE    1 
ATOM   1742 C CZ    . ARG A 1 225 ? -55.08448 32.70497  -19.94299 1.000 41.13174 ?  343 ARG A CZ    1 
ATOM   1743 N NH1   . ARG A 1 225 ? -55.45230 31.96608  -20.97706 1.000 45.50487 ?  343 ARG A NH1   1 
ATOM   1744 N NH2   . ARG A 1 225 ? -54.25831 33.73116  -20.13191 1.000 49.46854 ?  343 ARG A NH2   1 
ATOM   1745 N N     . VAL A 1 226 ? -57.17346 27.32251  -13.95258 1.000 31.49041 ?  344 VAL A N     1 
ATOM   1746 C CA    . VAL A 1 226 ? -57.83242 26.07588  -13.56539 1.000 31.69483 ?  344 VAL A CA    1 
ATOM   1747 C C     . VAL A 1 226 ? -58.81006 25.61857  -14.64678 1.000 34.06593 ?  344 VAL A C     1 
ATOM   1748 O O     . VAL A 1 226 ? -60.00083 25.40487  -14.38826 1.000 33.39599 ?  344 VAL A O     1 
ATOM   1749 C CB    . VAL A 1 226 ? -58.50905 26.20390  -12.18521 1.000 36.14895 ?  344 VAL A CB    1 
ATOM   1750 C CG1   . VAL A 1 226 ? -58.88373 24.81745  -11.65914 1.000 32.40660 ?  344 VAL A CG1   1 
ATOM   1751 C CG2   . VAL A 1 226 ? -57.54581 26.85480  -11.19883 1.000 34.93502 ?  344 VAL A CG2   1 
ATOM   1752 N N     . GLU A 1 227 ? -58.30410 25.44423  -15.87147 1.000 31.97710 ?  345 GLU A N     1 
ATOM   1753 C CA    . GLU A 1 227 ? -59.12647 25.04542  -17.01807 1.000 32.67585 ?  345 GLU A CA    1 
ATOM   1754 C C     . GLU A 1 227 ? -59.00903 23.54117  -17.19720 1.000 37.48088 ?  345 GLU A C     1 
ATOM   1755 O O     . GLU A 1 227 ? -58.06176 23.04472  -17.81059 1.000 38.80066 ?  345 GLU A O     1 
ATOM   1756 C CB    . GLU A 1 227 ? -58.70857 25.77895  -18.29139 1.000 34.15858 ?  345 GLU A CB    1 
ATOM   1757 C CG    . GLU A 1 227 ? -58.77209 27.26727  -18.18987 1.000 35.59376 ?  345 GLU A CG    1 
ATOM   1758 C CD    . GLU A 1 227 ? -58.17450 27.96075  -19.40571 1.000 40.33624 ?  345 GLU A CD    1 
ATOM   1759 O OE1   . GLU A 1 227 ? -57.55128 27.26837  -20.24238 1.000 43.91435 ?  345 GLU A OE1   1 
ATOM   1760 O OE2   . GLU A 1 227 ? -58.27511 29.19843  -19.48634 1.000 39.06828 -1 345 GLU A OE2   1 
ATOM   1761 N N     . PHE A 1 228 ? -59.97290 22.81748  -16.65055 1.000 35.74306 ?  346 PHE A N     1 
ATOM   1762 C CA    . PHE A 1 228 ? -60.03895 21.38278  -16.83930 1.000 38.52968 ?  346 PHE A CA    1 
ATOM   1763 C C     . PHE A 1 228 ? -61.49645 20.99444  -16.97798 1.000 37.33674 ?  346 PHE A C     1 
ATOM   1764 O O     . PHE A 1 228 ? -62.39498 21.70197  -16.50496 1.000 34.03869 ?  346 PHE A O     1 
ATOM   1765 C CB    . PHE A 1 228 ? -59.36966 20.60911  -15.69664 1.000 35.07115 ?  346 PHE A CB    1 
ATOM   1766 C CG    . PHE A 1 228 ? -60.10613 20.67676  -14.40281 1.000 38.49722 ?  346 PHE A CG    1 
ATOM   1767 C CD1   . PHE A 1 228 ? -60.01555 21.79718  -13.59542 1.000 36.38543 ?  346 PHE A CD1   1 
ATOM   1768 C CD2   . PHE A 1 228 ? -60.90421 19.62905  -13.99359 1.000 40.31391 ?  346 PHE A CD2   1 
ATOM   1769 C CE1   . PHE A 1 228 ? -60.70046 21.86470  -12.40098 1.000 37.25618 ?  346 PHE A CE1   1 
ATOM   1770 C CE2   . PHE A 1 228 ? -61.59950 19.70441  -12.81225 1.000 39.45654 ?  346 PHE A CE2   1 
ATOM   1771 C CZ    . PHE A 1 228 ? -61.50181 20.82124  -12.01838 1.000 42.03069 ?  346 PHE A CZ    1 
ATOM   1772 N N     . THR A 1 229 ? -61.72255 19.87304  -17.65615 1.000 33.11448 ?  347 THR A N     1 
ATOM   1773 C CA    . THR A 1 229 ? -63.06164 19.33039  -17.81796 1.000 34.48653 ?  347 THR A CA    1 
ATOM   1774 C C     . THR A 1 229 ? -63.00691 17.82695  -17.60053 1.000 36.23186 ?  347 THR A C     1 
ATOM   1775 O O     . THR A 1 229 ? -61.93517 17.21059  -17.66684 1.000 33.44675 ?  347 THR A O     1 
ATOM   1776 C CB    . THR A 1 229 ? -63.62517 19.64735  -19.21074 1.000 36.22838 ?  347 THR A CB    1 
ATOM   1777 O OG1   . THR A 1 229 ? -62.77380 19.06408  -20.20901 1.000 36.28549 ?  347 THR A OG1   1 
ATOM   1778 C CG2   . THR A 1 229 ? -63.67165 21.18599  -19.41724 1.000 32.64452 ?  347 THR A CG2   1 
ATOM   1779 N N     . PHE A 1 230 ? -64.19347 17.23898  -17.33058 1.000 34.60127 ?  348 PHE A N     1 
ATOM   1780 C CA    . PHE A 1 230 ? -64.30621 15.81949  -17.01143 1.000 35.57195 ?  348 PHE A CA    1 
ATOM   1781 C C     . PHE A 1 230 ? -64.85814 15.03879  -18.19340 1.000 36.61219 ?  348 PHE A C     1 
ATOM   1782 O O     . PHE A 1 230 ? -65.87695 15.44728  -18.77072 1.000 37.74705 ?  348 PHE A O     1 
ATOM   1783 C CB    . PHE A 1 230 ? -65.22781 15.59929  -15.81235 1.000 36.88255 ?  348 PHE A CB    1 
ATOM   1784 C CG    . PHE A 1 230 ? -64.72613 16.18016  -14.52590 1.000 34.39129 ?  348 PHE A CG    1 
ATOM   1785 C CD1   . PHE A 1 230 ? -63.75550 15.51836  -13.78740 1.000 34.28010 ?  348 PHE A CD1   1 
ATOM   1786 C CD2   . PHE A 1 230 ? -65.27317 17.35502  -14.02151 1.000 36.24676 ?  348 PHE A CD2   1 
ATOM   1787 C CE1   . PHE A 1 230 ? -63.29575 16.03180  -12.58271 1.000 33.89893 ?  348 PHE A CE1   1 
ATOM   1788 C CE2   . PHE A 1 230 ? -64.82825 17.88451  -12.81476 1.000 36.73752 ?  348 PHE A CE2   1 
ATOM   1789 C CZ    . PHE A 1 230 ? -63.83486 17.22163  -12.08747 1.000 35.18712 ?  348 PHE A CZ    1 
ATOM   1790 N N     . PRO A 1 231 ? -64.25614 13.89767  -18.54045 1.000 40.34066 ?  349 PRO A N     1 
ATOM   1791 C CA    . PRO A 1 231 ? -64.94789 12.92269  -19.39757 1.000 37.80809 ?  349 PRO A CA    1 
ATOM   1792 C C     . PRO A 1 231 ? -66.27474 12.51087  -18.78401 1.000 38.87654 ?  349 PRO A C     1 
ATOM   1793 O O     . PRO A 1 231 ? -66.50912 12.63679  -17.57923 1.000 38.02645 ?  349 PRO A O     1 
ATOM   1794 C CB    . PRO A 1 231 ? -63.97461 11.74000  -19.45708 1.000 42.45549 ?  349 PRO A CB    1 
ATOM   1795 C CG    . PRO A 1 231 ? -62.64583 12.33152  -19.10645 1.000 40.05511 ?  349 PRO A CG    1 
ATOM   1796 C CD    . PRO A 1 231 ? -62.92484 13.42334  -18.12565 1.000 37.44794 ?  349 PRO A CD    1 
ATOM   1797 N N     . ASP A 1 232 ? -67.15002 11.97965  -19.63686 1.000 42.23784 ?  350 ASP A N     1 
ATOM   1798 C CA    . ASP A 1 232 ? -68.52435 11.75740  -19.22405 1.000 43.71553 ?  350 ASP A CA    1 
ATOM   1799 C C     . ASP A 1 232 ? -68.64570 10.68711  -18.14553 1.000 43.93590 ?  350 ASP A C     1 
ATOM   1800 O O     . ASP A 1 232 ? -69.59863 10.72440  -17.36199 1.000 46.04950 ?  350 ASP A O     1 
ATOM   1801 C CB    . ASP A 1 232 ? -69.35814 11.39716  -20.45207 1.000 47.28531 ?  350 ASP A CB    1 
ATOM   1802 C CG    . ASP A 1 232 ? -69.86477 12.63395  -21.17625 1.000 53.15238 ?  350 ASP A CG    1 
ATOM   1803 O OD1   . ASP A 1 232 ? -69.78821 13.75276  -20.59943 1.000 55.81613 ?  350 ASP A OD1   1 
ATOM   1804 O OD2   . ASP A 1 232 ? -70.29734 12.49762  -22.34024 1.000 61.49089 -1 350 ASP A OD2   1 
ATOM   1805 N N     . PHE A 1 233 ? -67.68244 9.77205   -18.04656 1.000 40.82219 ?  351 PHE A N     1 
ATOM   1806 C CA    . PHE A 1 233 ? -67.80071 8.66308   -17.11313 1.000 40.37429 ?  351 PHE A CA    1 
ATOM   1807 C C     . PHE A 1 233 ? -67.39026 9.01303   -15.69060 1.000 41.65825 ?  351 PHE A C     1 
ATOM   1808 O O     . PHE A 1 233 ? -67.56356 8.17603   -14.79895 1.000 43.27940 ?  351 PHE A O     1 
ATOM   1809 C CB    . PHE A 1 233 ? -66.96304 7.46610   -17.58540 1.000 42.52608 ?  351 PHE A CB    1 
ATOM   1810 C CG    . PHE A 1 233 ? -65.49492 7.77200   -17.78531 1.000 39.40700 ?  351 PHE A CG    1 
ATOM   1811 C CD1   . PHE A 1 233 ? -64.62734 7.85720   -16.70627 1.000 40.88951 ?  351 PHE A CD1   1 
ATOM   1812 C CD2   . PHE A 1 233 ? -64.97739 7.93247   -19.06549 1.000 40.39418 ?  351 PHE A CD2   1 
ATOM   1813 C CE1   . PHE A 1 233 ? -63.27891 8.12688   -16.89878 1.000 38.36311 ?  351 PHE A CE1   1 
ATOM   1814 C CE2   . PHE A 1 233 ? -63.63557 8.20146   -19.26075 1.000 41.54143 ?  351 PHE A CE2   1 
ATOM   1815 C CZ    . PHE A 1 233 ? -62.78387 8.29854   -18.16910 1.000 37.91549 ?  351 PHE A CZ    1 
ATOM   1816 N N     . VAL A 1 234 ? -66.80263 10.18351  -15.45287 1.000 38.78737 ?  352 VAL A N     1 
ATOM   1817 C CA    . VAL A 1 234 ? -66.41773 10.53122  -14.08977 1.000 37.86872 ?  352 VAL A CA    1 
ATOM   1818 C C     . VAL A 1 234 ? -67.68911 10.78804  -13.29171 1.000 41.75592 ?  352 VAL A C     1 
ATOM   1819 O O     . VAL A 1 234 ? -68.50239 11.64561  -13.65682 1.000 39.96897 ?  352 VAL A O     1 
ATOM   1820 C CB    . VAL A 1 234 ? -65.47131 11.74084  -14.06687 1.000 37.23687 ?  352 VAL A CB    1 
ATOM   1821 C CG1   . VAL A 1 234 ? -65.06101 12.04732  -12.63424 1.000 36.89120 ?  352 VAL A CG1   1 
ATOM   1822 C CG2   . VAL A 1 234 ? -64.22072 11.43591  -14.88675 1.000 36.50026 ?  352 VAL A CG2   1 
ATOM   1823 N N     . THR A 1 235 ? -67.88132 10.02145  -12.21840 1.000 39.90916 ?  353 THR A N     1 
ATOM   1824 C CA    . THR A 1 235 ? -69.10785 10.11085  -11.43755 1.000 40.16281 ?  353 THR A CA    1 
ATOM   1825 C C     . THR A 1 235 ? -69.15621 11.40760  -10.63279 1.000 40.76597 ?  353 THR A C     1 
ATOM   1826 O O     . THR A 1 235 ? -68.14819 12.09954  -10.44922 1.000 40.27253 ?  353 THR A O     1 
ATOM   1827 C CB    . THR A 1 235 ? -69.23743 8.91842   -10.49051 1.000 40.71825 ?  353 THR A CB    1 
ATOM   1828 O OG1   . THR A 1 235 ? -68.29124 9.05785   -9.42321  1.000 39.08878 ?  353 THR A OG1   1 
ATOM   1829 C CG2   . THR A 1 235 ? -68.99565 7.61795   -11.22285 1.000 41.43485 ?  353 THR A CG2   1 
ATOM   1830 N N     . GLU A 1 236 ? -70.35886 11.72438  -10.12935 1.000 41.03585 ?  354 GLU A N     1 
ATOM   1831 C CA    . GLU A 1 236 ? -70.58183 13.02190  -9.49439  1.000 41.59175 ?  354 GLU A CA    1 
ATOM   1832 C C     . GLU A 1 236 ? -69.77574 13.15880  -8.21531  1.000 37.53363 ?  354 GLU A C     1 
ATOM   1833 O O     . GLU A 1 236 ? -69.28211 14.24845  -7.90230  1.000 37.75961 ?  354 GLU A O     1 
ATOM   1834 C CB    . GLU A 1 236 ? -72.07704 13.23983  -9.20844  1.000 45.42853 ?  354 GLU A CB    1 
ATOM   1835 N N     . GLY A 1 237 ? -69.62683 12.07085  -7.46073  1.000 38.22320 ?  355 GLY A N     1 
ATOM   1836 C CA    . GLY A 1 237 ? -68.82870 12.14268  -6.24604  1.000 39.36451 ?  355 GLY A CA    1 
ATOM   1837 C C     . GLY A 1 237 ? -67.37004 12.43921  -6.54246  1.000 36.38281 ?  355 GLY A C     1 
ATOM   1838 O O     . GLY A 1 237 ? -66.74195 13.26786  -5.87917  1.000 38.82682 ?  355 GLY A O     1 
ATOM   1839 N N     . ALA A 1 238 ? -66.81542 11.76212  -7.55097  1.000 35.48858 ?  356 ALA A N     1 
ATOM   1840 C CA    . ALA A 1 238 ? -65.43909 12.02880  -7.96085  1.000 37.35945 ?  356 ALA A CA    1 
ATOM   1841 C C     . ALA A 1 238 ? -65.27495 13.46741  -8.42692  1.000 38.14590 ?  356 ALA A C     1 
ATOM   1842 O O     . ALA A 1 238 ? -64.29519 14.13174  -8.07112  1.000 35.58321 ?  356 ALA A O     1 
ATOM   1843 C CB    . ALA A 1 238 ? -65.02757 11.06293  -9.07131  1.000 36.21918 ?  356 ALA A CB    1 
ATOM   1844 N N     . ARG A 1 239 ? -66.22677 13.96725  -9.22700  1.000 33.59512 ?  357 ARG A N     1 
ATOM   1845 C CA    . ARG A 1 239 ? -66.18208 15.36145  -9.65135  1.000 34.26110 ?  357 ARG A CA    1 
ATOM   1846 C C     . ARG A 1 239 ? -66.15048 16.30293  -8.46127  1.000 35.41060 ?  357 ARG A C     1 
ATOM   1847 O O     . ARG A 1 239 ? -65.44543 17.31761  -8.48331  1.000 35.78885 ?  357 ARG A O     1 
ATOM   1848 C CB    . ARG A 1 239 ? -67.38535 15.70056  -10.54128 1.000 34.76224 ?  357 ARG A CB    1 
ATOM   1849 C CG    . ARG A 1 239 ? -67.30010 15.08545  -11.92758 1.000 37.07264 ?  357 ARG A CG    1 
ATOM   1850 C CD    . ARG A 1 239 ? -68.55659 15.38748  -12.74813 1.000 40.24655 ?  357 ARG A CD    1 
ATOM   1851 N NE    . ARG A 1 239 ? -68.64202 14.48730  -13.89171 1.000 42.68549 ?  357 ARG A NE    1 
ATOM   1852 C CZ    . ARG A 1 239 ? -68.72734 14.86309  -15.15927 1.000 45.05343 ?  357 ARG A CZ    1 
ATOM   1853 N NH1   . ARG A 1 239 ? -68.77845 16.14404  -15.50005 1.000 43.78487 ?  357 ARG A NH1   1 
ATOM   1854 N NH2   . ARG A 1 239 ? -68.80505 13.92793  -16.10719 1.000 39.25178 ?  357 ARG A NH2   1 
ATOM   1855 N N     . ASP A 1 240 ? -66.92284 15.99538  -7.41822  1.000 37.15963 ?  358 ASP A N     1 
ATOM   1856 C CA    . ASP A 1 240 ? -67.01081 16.90831  -6.28653  1.000 39.43743 ?  358 ASP A CA    1 
ATOM   1857 C C     . ASP A 1 240 ? -65.69643 16.97745  -5.52461  1.000 35.76918 ?  358 ASP A C     1 
ATOM   1858 O O     . ASP A 1 240 ? -65.23344 18.07104  -5.17611  1.000 35.00045 ?  358 ASP A O     1 
ATOM   1859 C CB    . ASP A 1 240 ? -68.14877 16.49225  -5.35684  1.000 39.51967 ?  358 ASP A CB    1 
ATOM   1860 C CG    . ASP A 1 240 ? -68.29059 17.43939  -4.17488  1.000 44.52832 ?  358 ASP A CG    1 
ATOM   1861 O OD1   . ASP A 1 240 ? -68.88632 18.52284  -4.35446  1.000 47.09481 ?  358 ASP A OD1   1 
ATOM   1862 O OD2   . ASP A 1 240 ? -67.79987 17.10698  -3.07465  1.000 44.61421 -1 358 ASP A OD2   1 
ATOM   1863 N N     . LEU A 1 241 ? -65.06726 15.82855  -5.27745  1.000 34.71187 ?  359 LEU A N     1 
ATOM   1864 C CA    . LEU A 1 241 ? -63.78569 15.83539  -4.57799  1.000 33.24237 ?  359 LEU A CA    1 
ATOM   1865 C C     . LEU A 1 241 ? -62.71954 16.54091  -5.40567  1.000 32.35098 ?  359 LEU A C     1 
ATOM   1866 O O     . LEU A 1 241 ? -62.02672 17.43733  -4.91125  1.000 31.74935 ?  359 LEU A O     1 
ATOM   1867 C CB    . LEU A 1 241 ? -63.35680 14.40232  -4.24809  1.000 36.92600 ?  359 LEU A CB    1 
ATOM   1868 C CG    . LEU A 1 241 ? -61.95717 14.26215  -3.63916  1.000 31.55023 ?  359 LEU A CG    1 
ATOM   1869 C CD1   . LEU A 1 241 ? -61.87025 15.02817  -2.31080  1.000 34.23882 ?  359 LEU A CD1   1 
ATOM   1870 C CD2   . LEU A 1 241 ? -61.60467 12.79255  -3.44019  1.000 32.82898 ?  359 LEU A CD2   1 
ATOM   1871 N N     . ILE A 1 242 ? -62.61183 16.18786  -6.68759  1.000 31.24672 ?  360 ILE A N     1 
ATOM   1872 C CA    . ILE A 1 242 ? -61.58388 16.79516  -7.53123  1.000 30.67507 ?  360 ILE A CA    1 
ATOM   1873 C C     . ILE A 1 242 ? -61.79696 18.29828  -7.63944  1.000 32.06309 ?  360 ILE A C     1 
ATOM   1874 O O     . ILE A 1 242 ? -60.83555 19.07813  -7.60409  1.000 30.72944 ?  360 ILE A O     1 
ATOM   1875 C CB    . ILE A 1 242 ? -61.55410 16.11759  -8.91735  1.000 31.26951 ?  360 ILE A CB    1 
ATOM   1876 C CG1   . ILE A 1 242 ? -61.00515 14.68655  -8.80041  1.000 30.39488 ?  360 ILE A CG1   1 
ATOM   1877 C CG2   . ILE A 1 242 ? -60.68304 16.92204  -9.87924  1.000 32.54296 ?  360 ILE A CG2   1 
ATOM   1878 C CD1   . ILE A 1 242 ? -61.31002 13.80883  -10.03215 1.000 29.53296 ?  360 ILE A CD1   1 
ATOM   1879 N N     . SER A 1 243 ? -63.05890 18.72606  -7.77828  1.000 31.63006 ?  361 SER A N     1 
ATOM   1880 C CA    . SER A 1 243 ? -63.34917 20.14741  -7.90748  1.000 33.53438 ?  361 SER A CA    1 
ATOM   1881 C C     . SER A 1 243 ? -62.96933 20.89822  -6.63938  1.000 34.65176 ?  361 SER A C     1 
ATOM   1882 O O     . SER A 1 243 ? -62.50988 22.04197  -6.71525  1.000 35.32097 ?  361 SER A O     1 
ATOM   1883 C CB    . SER A 1 243 ? -64.83225 20.35058  -8.23154  1.000 35.32822 ?  361 SER A CB    1 
ATOM   1884 O OG    . SER A 1 243 ? -65.12998 19.93996  -9.55991  1.000 38.05918 ?  361 SER A OG    1 
ATOM   1885 N N     . ARG A 1 244 ? -63.14242 20.27554  -5.46501  1.000 32.49045 ?  362 ARG A N     1 
ATOM   1886 C CA    . ARG A 1 244 ? -62.74190 20.94471  -4.22660  1.000 34.41483 ?  362 ARG A CA    1 
ATOM   1887 C C     . ARG A 1 244 ? -61.23273 20.99508  -4.05396  1.000 35.83711 ?  362 ARG A C     1 
ATOM   1888 O O     . ARG A 1 244 ? -60.71312 21.97669  -3.51071  1.000 34.48641 ?  362 ARG A O     1 
ATOM   1889 C CB    . ARG A 1 244 ? -63.39343 20.27978  -3.01911  1.000 36.72054 ?  362 ARG A CB    1 
ATOM   1890 C CG    . ARG A 1 244 ? -64.91447 20.39807  -3.01728  1.000 39.89149 ?  362 ARG A CG    1 
ATOM   1891 C CD    . ARG A 1 244 ? -65.51489 19.67492  -1.83215  1.000 42.01759 ?  362 ARG A CD    1 
ATOM   1892 N NE    . ARG A 1 244 ? -66.93158 19.39435  -2.03598  1.000 47.93030 ?  362 ARG A NE    1 
ATOM   1893 C CZ    . ARG A 1 244 ? -67.91877 20.11850  -1.52401  1.000 54.62081 ?  362 ARG A CZ    1 
ATOM   1894 N NH1   . ARG A 1 244 ? -67.67798 21.16932  -0.75375  1.000 55.35526 ?  362 ARG A NH1   1 
ATOM   1895 N NH2   . ARG A 1 244 ? -69.18029 19.78210  -1.79274  1.000 53.74021 ?  362 ARG A NH2   1 
ATOM   1896 N N     . LEU A 1 245 ? -60.50655 19.98072  -4.53771  1.000 31.59884 ?  363 LEU A N     1 
ATOM   1897 C CA    . LEU A 1 245 ? -59.04932 19.99228  -4.40729  1.000 30.92557 ?  363 LEU A CA    1 
ATOM   1898 C C     . LEU A 1 245 ? -58.38849 20.96565  -5.37528  1.000 31.12066 ?  363 LEU A C     1 
ATOM   1899 O O     . LEU A 1 245 ? -57.35495 21.57584  -5.05030  1.000 32.32899 ?  363 LEU A O     1 
ATOM   1900 C CB    . LEU A 1 245 ? -58.49824 18.57674  -4.61512  1.000 33.54669 ?  363 LEU A CB    1 
ATOM   1901 C CG    . LEU A 1 245 ? -58.87822 17.56405  -3.52302  1.000 32.77971 ?  363 LEU A CG    1 
ATOM   1902 C CD1   . LEU A 1 245 ? -58.63371 16.10961  -4.00764  1.000 32.49024 ?  363 LEU A CD1   1 
ATOM   1903 C CD2   . LEU A 1 245 ? -58.12119 17.84166  -2.20490  1.000 33.41081 ?  363 LEU A CD2   1 
ATOM   1904 N N     . LEU A 1 246 ? -58.93796 21.10633  -6.57296  1.000 29.78106 ?  364 LEU A N     1 
ATOM   1905 C CA    . LEU A 1 246 ? -58.36037 21.98698  -7.58624  1.000 29.41690 ?  364 LEU A CA    1 
ATOM   1906 C C     . LEU A 1 246 ? -58.95164 23.39882  -7.52419  1.000 32.86723 ?  364 LEU A C     1 
ATOM   1907 O O     . LEU A 1 246 ? -59.25821 24.00012  -8.54978  1.000 35.36292 ?  364 LEU A O     1 
ATOM   1908 C CB    . LEU A 1 246 ? -58.55463 21.36851  -8.97582  1.000 30.27245 ?  364 LEU A CB    1 
ATOM   1909 C CG    . LEU A 1 246 ? -57.85558 19.99735  -9.15514  1.000 29.70410 ?  364 LEU A CG    1 
ATOM   1910 C CD1   . LEU A 1 246 ? -58.04990 19.40408  -10.56540 1.000 31.95562 ?  364 LEU A CD1   1 
ATOM   1911 C CD2   . LEU A 1 246 ? -56.34285 20.10009  -8.81971  1.000 30.55580 ?  364 LEU A CD2   1 
ATOM   1912 N N     . LYS A 1 247 ? -59.14610 23.95025  -6.33593  1.000 35.58448 ?  365 LYS A N     1 
ATOM   1913 C CA    . LYS A 1 247 ? -59.54380 25.35146  -6.21851  1.000 34.64169 ?  365 LYS A CA    1 
ATOM   1914 C C     . LYS A 1 247 ? -58.32643 26.23147  -6.42775  1.000 34.13089 ?  365 LYS A C     1 
ATOM   1915 O O     . LYS A 1 247 ? -57.24840 25.94108  -5.90605  1.000 33.41892 ?  365 LYS A O     1 
ATOM   1916 C CB    . LYS A 1 247 ? -60.14948 25.62815  -4.84020  1.000 34.10442 ?  365 LYS A CB    1 
ATOM   1917 C CG    . LYS A 1 247 ? -61.42579 24.88575  -4.55703  1.000 38.46623 ?  365 LYS A CG    1 
ATOM   1918 C CD    . LYS A 1 247 ? -62.64925 25.66441  -4.98704  1.000 45.10397 ?  365 LYS A CD    1 
ATOM   1919 C CE    . LYS A 1 247 ? -63.80342 24.71911  -5.25971  1.000 48.57421 ?  365 LYS A CE    1 
ATOM   1920 N NZ    . LYS A 1 247 ? -65.13746 25.38660  -5.27967  1.000 55.96346 ?  365 LYS A NZ    1 
ATOM   1921 N N     . HIS A 1 248 ? -58.49534 27.32268  -7.19094  1.000 33.59369 ?  366 HIS A N     1 
ATOM   1922 C CA    . HIS A 1 248 ? -57.38067 28.24336  -7.38469  1.000 33.19856 ?  366 HIS A CA    1 
ATOM   1923 C C     . HIS A 1 248 ? -56.89742 28.80857  -6.05297  1.000 37.71007 ?  366 HIS A C     1 
ATOM   1924 O O     . HIS A 1 248 ? -55.69618 28.99750  -5.84516  1.000 37.92916 ?  366 HIS A O     1 
ATOM   1925 C CB    . HIS A 1 248 ? -57.77901 29.39598  -8.30759  1.000 35.99870 ?  366 HIS A CB    1 
ATOM   1926 C CG    . HIS A 1 248 ? -56.64092 30.31329  -8.61562  1.000 39.75663 ?  366 HIS A CG    1 
ATOM   1927 N ND1   . HIS A 1 248 ? -56.39758 31.46157  -7.89318  1.000 39.40343 ?  366 HIS A ND1   1 
ATOM   1928 C CD2   . HIS A 1 248 ? -55.67824 30.25497  -9.56705  1.000 38.69261 ?  366 HIS A CD2   1 
ATOM   1929 C CE1   . HIS A 1 248 ? -55.33183 32.06907  -8.38272  1.000 41.07360 ?  366 HIS A CE1   1 
ATOM   1930 N NE2   . HIS A 1 248 ? -54.87679 31.35919  -9.39980  1.000 41.60920 ?  366 HIS A NE2   1 
ATOM   1931 N N     . ASN A 1 249 ? -57.82527 29.12665  -5.17095  1.000 36.53201 ?  367 ASN A N     1 
ATOM   1932 C CA    . ASN A 1 249 ? -57.50536 29.74082  -3.89178  1.000 37.37598 ?  367 ASN A CA    1 
ATOM   1933 C C     . ASN A 1 249 ? -57.14705 28.65001  -2.89027  1.000 33.57200 ?  367 ASN A C     1 
ATOM   1934 O O     . ASN A 1 249 ? -58.00807 27.83826  -2.55138  1.000 34.77238 ?  367 ASN A O     1 
ATOM   1935 C CB    . ASN A 1 249 ? -58.71300 30.53690  -3.42027  1.000 36.85305 ?  367 ASN A CB    1 
ATOM   1936 C CG    . ASN A 1 249 ? -58.51652 31.18127  -2.06260  1.000 45.05849 ?  367 ASN A CG    1 
ATOM   1937 O OD1   . ASN A 1 249 ? -57.54228 30.91751  -1.35167  1.000 42.32515 ?  367 ASN A OD1   1 
ATOM   1938 N ND2   . ASN A 1 249 ? -59.44902 32.06560  -1.70763  1.000 46.99386 ?  367 ASN A ND2   1 
ATOM   1939 N N     . PRO A 1 250 ? -55.90666 28.59318  -2.40242  1.000 34.48530 ?  368 PRO A N     1 
ATOM   1940 C CA    . PRO A 1 250 ? -55.51197 27.45721  -1.55262  1.000 37.98208 ?  368 PRO A CA    1 
ATOM   1941 C C     . PRO A 1 250 ? -56.33679 27.34104  -0.28836  1.000 39.40936 ?  368 PRO A C     1 
ATOM   1942 O O     . PRO A 1 250 ? -56.59358 26.21388  0.15957   1.000 37.00334 ?  368 PRO A O     1 
ATOM   1943 C CB    . PRO A 1 250 ? -54.03710 27.74286  -1.24512  1.000 37.07549 ?  368 PRO A CB    1 
ATOM   1944 C CG    . PRO A 1 250 ? -53.57701 28.57280  -2.36209  1.000 40.34563 ?  368 PRO A CG    1 
ATOM   1945 C CD    . PRO A 1 250 ? -54.75858 29.43993  -2.75304  1.000 37.18366 ?  368 PRO A CD    1 
ATOM   1946 N N     . SER A 1 251 ? -56.80577 28.47310  0.27018   1.000 37.37458 ?  369 SER A N     1 
ATOM   1947 C CA    . SER A 1 251 ? -57.62196 28.45451  1.48162   1.000 40.17005 ?  369 SER A CA    1 
ATOM   1948 C C     . SER A 1 251 ? -58.95154 27.75597  1.27954   1.000 42.84621 ?  369 SER A C     1 
ATOM   1949 O O     . SER A 1 251 ? -59.59122 27.36382  2.26284   1.000 43.85947 ?  369 SER A O     1 
ATOM   1950 C CB    . SER A 1 251 ? -57.88430 29.88756  1.96754   1.000 40.98255 ?  369 SER A CB    1 
ATOM   1951 O OG    . SER A 1 251 ? -56.64811 30.54174  2.17234   1.000 49.01181 ?  369 SER A OG    1 
ATOM   1952 N N     . GLN A 1 252 ? -59.39588 27.62127  0.03725   1.000 37.50893 ?  370 GLN A N     1 
ATOM   1953 C CA    . GLN A 1 252 ? -60.64219 26.94437  -0.26397  1.000 42.28361 ?  370 GLN A CA    1 
ATOM   1954 C C     . GLN A 1 252 ? -60.47831 25.43469  -0.38994  1.000 38.19759 ?  370 GLN A C     1 
ATOM   1955 O O     . GLN A 1 252 ? -61.47872 24.71927  -0.46042  1.000 41.22068 ?  370 GLN A O     1 
ATOM   1956 C CB    . GLN A 1 252 ? -61.20667 27.48629  -1.57107  1.000 47.23954 ?  370 GLN A CB    1 
ATOM   1957 C CG    . GLN A 1 252 ? -62.63838 27.12763  -1.78546  1.000 53.91355 ?  370 GLN A CG    1 
ATOM   1958 C CD    . GLN A 1 252 ? -63.53522 28.18047  -1.19864  1.000 63.95980 ?  370 GLN A CD    1 
ATOM   1959 O OE1   . GLN A 1 252 ? -64.69375 27.91924  -0.86473  1.000 67.87577 ?  370 GLN A OE1   1 
ATOM   1960 N NE2   . GLN A 1 252 ? -63.00525 29.39901  -1.08394  1.000 61.94176 ?  370 GLN A NE2   1 
ATOM   1961 N N     . ARG A 1 253 ? -59.24769 24.94691  -0.45827  1.000 35.13604 ?  371 ARG A N     1 
ATOM   1962 C CA    . ARG A 1 253 ? -59.00135 23.52140  -0.58736  1.000 33.59212 ?  371 ARG A CA    1 
ATOM   1963 C C     . ARG A 1 253 ? -59.26739 22.82125  0.74564   1.000 36.82861 ?  371 ARG A C     1 
ATOM   1964 O O     . ARG A 1 253 ? -58.96884 23.36984  1.80523   1.000 37.22578 ?  371 ARG A O     1 
ATOM   1965 C CB    . ARG A 1 253 ? -57.55773 23.28837  -1.02758  1.000 32.90981 ?  371 ARG A CB    1 
ATOM   1966 C CG    . ARG A 1 253 ? -57.31351 23.75322  -2.45941  1.000 32.21332 ?  371 ARG A CG    1 
ATOM   1967 C CD    . ARG A 1 253 ? -55.84625 23.60244  -2.88334  1.000 32.93538 ?  371 ARG A CD    1 
ATOM   1968 N NE    . ARG A 1 253 ? -55.56194 24.53397  -3.97042  1.000 30.86054 ?  371 ARG A NE    1 
ATOM   1969 C CZ    . ARG A 1 253 ? -54.38624 25.11479  -4.18093  1.000 29.52076 ?  371 ARG A CZ    1 
ATOM   1970 N NH1   . ARG A 1 253 ? -53.30376 24.77299  -3.48811  1.000 32.14950 ?  371 ARG A NH1   1 
ATOM   1971 N NH2   . ARG A 1 253 ? -54.28983 26.05562  -5.11539  1.000 32.01637 ?  371 ARG A NH2   1 
ATOM   1972 N N     . PRO A 1 254 ? -59.79278 21.60140  0.71965   1.000 33.16936 ?  372 PRO A N     1 
ATOM   1973 C CA    . PRO A 1 254 ? -60.11555 20.92600  1.97493   1.000 35.84973 ?  372 PRO A CA    1 
ATOM   1974 C C     . PRO A 1 254 ? -58.88062 20.57597  2.79780   1.000 36.15376 ?  372 PRO A C     1 
ATOM   1975 O O     . PRO A 1 254 ? -57.72974 20.60024  2.34087   1.000 34.55344 ?  372 PRO A O     1 
ATOM   1976 C CB    . PRO A 1 254 ? -60.87093 19.66847  1.52290   1.000 40.51661 ?  372 PRO A CB    1 
ATOM   1977 C CG    . PRO A 1 254 ? -60.47467 19.45980  0.11189   1.000 38.03272 ?  372 PRO A CG    1 
ATOM   1978 C CD    . PRO A 1 254 ? -60.23702 20.82509  -0.45423  1.000 34.56827 ?  372 PRO A CD    1 
ATOM   1979 N N     . MET A 1 255 ? -59.14609 20.30958  4.06978   1.000 32.37671 ?  373 MET A N     1 
ATOM   1980 C CA    . MET A 1 255 ? -58.15615 19.72969  4.96230   1.000 33.31666 ?  373 MET A CA    1 
ATOM   1981 C C     . MET A 1 255 ? -57.99597 18.25133  4.59887   1.000 31.96693 ?  373 MET A C     1 
ATOM   1982 O O     . MET A 1 255 ? -58.89666 17.64530  4.02894   1.000 33.06161 ?  373 MET A O     1 
ATOM   1983 C CB    . MET A 1 255 ? -58.65475 19.89587  6.40152   1.000 35.86096 ?  373 MET A CB    1 
ATOM   1984 C CG    . MET A 1 255 ? -58.58435 21.32295  6.91945   1.000 37.00104 ?  373 MET A CG    1 
ATOM   1985 S SD    . MET A 1 255 ? -58.94717 21.39088  8.69661   1.000 44.72649 ?  373 MET A SD    1 
ATOM   1986 C CE    . MET A 1 255 ? -60.67482 20.99238  8.65814   1.000 39.72709 ?  373 MET A CE    1 
ATOM   1987 N N     . LEU A 1 256 ? -56.83402 17.66024  4.91218   1.000 33.61836 ?  374 LEU A N     1 
ATOM   1988 C CA    . LEU A 1 256 ? -56.66222 16.25636  4.54227   1.000 33.80980 ?  374 LEU A CA    1 
ATOM   1989 C C     . LEU A 1 256 ? -57.67107 15.37535  5.27528   1.000 36.87511 ?  374 LEU A C     1 
ATOM   1990 O O     . LEU A 1 256 ? -58.15864 14.38272  4.71898   1.000 33.69735 ?  374 LEU A O     1 
ATOM   1991 C CB    . LEU A 1 256 ? -55.21680 15.79960  4.82181   1.000 32.34303 ?  374 LEU A CB    1 
ATOM   1992 C CG    . LEU A 1 256 ? -54.12281 16.34787  3.89309   1.000 33.22368 ?  374 LEU A CG    1 
ATOM   1993 C CD1   . LEU A 1 256 ? -52.75061 16.23414  4.49761   1.000 35.41543 ?  374 LEU A CD1   1 
ATOM   1994 C CD2   . LEU A 1 256 ? -54.16310 15.58293  2.58151   1.000 36.55151 ?  374 LEU A CD2   1 
ATOM   1995 N N     . ARG A 1 257 ? -58.02981 15.73415  6.51618   1.000 33.67991 ?  375 ARG A N     1 
ATOM   1996 C CA    . ARG A 1 257 ? -59.03776 14.94123  7.21369   1.000 35.86521 ?  375 ARG A CA    1 
ATOM   1997 C C     . ARG A 1 257 ? -60.39602 15.02658  6.51118   1.000 36.07460 ?  375 ARG A C     1 
ATOM   1998 O O     . ARG A 1 257 ? -61.19055 14.07670  6.56713   1.000 37.83381 ?  375 ARG A O     1 
ATOM   1999 C CB    . ARG A 1 257 ? -59.11733 15.38011  8.68681   1.000 40.48754 ?  375 ARG A CB    1 
ATOM   2000 C CG    . ARG A 1 257 ? -59.96492 16.61401  8.96704   1.000 41.24136 ?  375 ARG A CG    1 
ATOM   2001 C CD    . ARG A 1 257 ? -60.47111 16.61012  10.41894  1.000 42.72608 ?  375 ARG A CD    1 
ATOM   2002 N NE    . ARG A 1 257 ? -60.86412 17.94131  10.88079  1.000 39.65325 ?  375 ARG A NE    1 
ATOM   2003 C CZ    . ARG A 1 257 ? -62.08826 18.43633  10.74037  1.000 43.72794 ?  375 ARG A CZ    1 
ATOM   2004 N NH1   . ARG A 1 257 ? -63.03976 17.75574  10.12435  1.000 40.82959 ?  375 ARG A NH1   1 
ATOM   2005 N NH2   . ARG A 1 257 ? -62.37004 19.63618  11.24482  1.000 40.56139 ?  375 ARG A NH2   1 
ATOM   2006 N N     . GLU A 1 258 ? -60.66541 16.13255  5.80981   1.000 35.29249 ?  376 GLU A N     1 
ATOM   2007 C CA    . GLU A 1 258 ? -61.90877 16.23879  5.04522   1.000 36.92299 ?  376 GLU A CA    1 
ATOM   2008 C C     . GLU A 1 258 ? -61.87401 15.39765  3.77071   1.000 36.85453 ?  376 GLU A C     1 
ATOM   2009 O O     . GLU A 1 258 ? -62.91931 14.90845  3.31900   1.000 38.56532 ?  376 GLU A O     1 
ATOM   2010 C CB    . GLU A 1 258 ? -62.18005 17.70704  4.72249   1.000 35.43363 ?  376 GLU A CB    1 
ATOM   2011 C CG    . GLU A 1 258 ? -62.56816 18.48834  5.96574   1.000 39.46261 ?  376 GLU A CG    1 
ATOM   2012 C CD    . GLU A 1 258 ? -62.74674 19.96185  5.70135   1.000 43.66053 ?  376 GLU A CD    1 
ATOM   2013 O OE1   . GLU A 1 258 ? -61.87699 20.57225  5.04098   1.000 41.51160 ?  376 GLU A OE1   1 
ATOM   2014 O OE2   . GLU A 1 258 ? -63.77375 20.51185  6.14594   1.000 44.20735 -1 376 GLU A OE2   1 
ATOM   2015 N N     . VAL A 1 259 ? -60.69800 15.23890  3.16326   1.000 36.14097 ?  377 VAL A N     1 
ATOM   2016 C CA    . VAL A 1 259 ? -60.55378 14.28903  2.06143   1.000 36.09894 ?  377 VAL A CA    1 
ATOM   2017 C C     . VAL A 1 259 ? -60.88699 12.88479  2.54887   1.000 36.57922 ?  377 VAL A C     1 
ATOM   2018 O O     . VAL A 1 259 ? -61.67887 12.15385  1.93647   1.000 35.68514 ?  377 VAL A O     1 
ATOM   2019 C CB    . VAL A 1 259 ? -59.12302 14.36259  1.48498   1.000 35.41569 ?  377 VAL A CB    1 
ATOM   2020 C CG1   . VAL A 1 259 ? -58.87788 13.23910  0.47038   1.000 36.07765 ?  377 VAL A CG1   1 
ATOM   2021 C CG2   . VAL A 1 259 ? -58.84794 15.75406  0.86935   1.000 34.02438 ?  377 VAL A CG2   1 
ATOM   2022 N N     . LEU A 1 260 ? -60.29340 12.49622  3.67518   1.000 35.32069 ?  378 LEU A N     1 
ATOM   2023 C CA    . LEU A 1 260 ? -60.46229 11.13743  4.17180   1.000 37.90744 ?  378 LEU A CA    1 
ATOM   2024 C C     . LEU A 1 260 ? -61.91533 10.83718  4.53051   1.000 40.65251 ?  378 LEU A C     1 
ATOM   2025 O O     . LEU A 1 260 ? -62.33610 9.67813   4.47452   1.000 44.19987 ?  378 LEU A O     1 
ATOM   2026 C CB    . LEU A 1 260 ? -59.54430 10.91712  5.36938   1.000 37.75239 ?  378 LEU A CB    1 
ATOM   2027 C CG    . LEU A 1 260 ? -58.05116 10.90057  5.00075   1.000 40.16115 ?  378 LEU A CG    1 
ATOM   2028 C CD1   . LEU A 1 260 ? -57.16454 11.04123  6.22998   1.000 38.92435 ?  378 LEU A CD1   1 
ATOM   2029 C CD2   . LEU A 1 260 ? -57.74465 9.60962   4.26231   1.000 38.27352 ?  378 LEU A CD2   1 
ATOM   2030 N N     . GLU A 1 261 ? -62.68884 11.85544  4.89736   1.000 39.09324 ?  379 GLU A N     1 
ATOM   2031 C CA    . GLU A 1 261 ? -64.09964 11.69812  5.23157   1.000 42.60641 ?  379 GLU A CA    1 
ATOM   2032 C C     . GLU A 1 261 ? -65.02847 12.00819  4.06430   1.000 42.99869 ?  379 GLU A C     1 
ATOM   2033 O O     . GLU A 1 261 ? -66.25215 11.90805  4.21571   1.000 40.61781 ?  379 GLU A O     1 
ATOM   2034 C CB    . GLU A 1 261 ? -64.45412 12.59255  6.42653   1.000 45.41765 ?  379 GLU A CB    1 
ATOM   2035 N N     . HIS A 1 262 ? -64.48940 12.39523  2.91060   1.000 42.29716 ?  380 HIS A N     1 
ATOM   2036 C CA    . HIS A 1 262 ? -65.35358 12.71773  1.78567   1.000 40.25001 ?  380 HIS A CA    1 
ATOM   2037 C C     . HIS A 1 262 ? -66.21375 11.50765  1.43226   1.000 39.18720 ?  380 HIS A C     1 
ATOM   2038 O O     . HIS A 1 262 ? -65.71200 10.37836  1.41228   1.000 40.20180 ?  380 HIS A O     1 
ATOM   2039 C CB    . HIS A 1 262 ? -64.53050 13.13781  0.57025   1.000 38.86571 ?  380 HIS A CB    1 
ATOM   2040 C CG    . HIS A 1 262 ? -65.35177 13.71382  -0.53494  1.000 35.66718 ?  380 HIS A CG    1 
ATOM   2041 N ND1   . HIS A 1 262 ? -66.07203 12.92830  -1.40492  1.000 37.58841 ?  380 HIS A ND1   1 
ATOM   2042 C CD2   . HIS A 1 262 ? -65.54502 14.99315  -0.93296  1.000 37.48351 ?  380 HIS A CD2   1 
ATOM   2043 C CE1   . HIS A 1 262 ? -66.68658 13.69765  -2.28609  1.000 37.52048 ?  380 HIS A CE1   1 
ATOM   2044 N NE2   . HIS A 1 262 ? -66.38194 14.95511  -2.02354  1.000 37.08051 ?  380 HIS A NE2   1 
ATOM   2045 N N     . PRO A 1 263 ? -67.50886 11.70265  1.15834   1.000 40.62530 ?  381 PRO A N     1 
ATOM   2046 C CA    . PRO A 1 263 ? -68.39747 10.54757  0.95241   1.000 40.76301 ?  381 PRO A CA    1 
ATOM   2047 C C     . PRO A 1 263 ? -67.98596 9.66452   -0.20623  1.000 40.04249 ?  381 PRO A C     1 
ATOM   2048 O O     . PRO A 1 263 ? -68.24106 8.45598   -0.16990  1.000 40.54344 ?  381 PRO A O     1 
ATOM   2049 C CB    . PRO A 1 263 ? -69.75826 11.20460  0.68568   1.000 43.41914 ?  381 PRO A CB    1 
ATOM   2050 C CG    . PRO A 1 263 ? -69.65376 12.55510  1.30408   1.000 45.19235 ?  381 PRO A CG    1 
ATOM   2051 C CD    . PRO A 1 263 ? -68.24127 12.97521  1.08470   1.000 41.51292 ?  381 PRO A CD    1 
ATOM   2052 N N     . TRP A 1 264 ? -67.39329 10.23624  -1.25803  1.000 37.69776 ?  382 TRP A N     1 
ATOM   2053 C CA    . TRP A 1 264 ? -66.91231 9.40872   -2.36406  1.000 37.59096 ?  382 TRP A CA    1 
ATOM   2054 C C     . TRP A 1 264 ? -65.73771 8.54166   -1.92866  1.000 37.83321 ?  382 TRP A C     1 
ATOM   2055 O O     . TRP A 1 264 ? -65.63508 7.37734   -2.33180  1.000 39.16964 ?  382 TRP A O     1 
ATOM   2056 C CB    . TRP A 1 264 ? -66.52632 10.28876  -3.55167  1.000 36.86847 ?  382 TRP A CB    1 
ATOM   2057 C CG    . TRP A 1 264 ? -66.09944 9.51993   -4.76494  1.000 37.01932 ?  382 TRP A CG    1 
ATOM   2058 C CD1   . TRP A 1 264 ? -66.91128 8.94170   -5.69328  1.000 36.95838 ?  382 TRP A CD1   1 
ATOM   2059 C CD2   . TRP A 1 264 ? -64.75079 9.25484   -5.18893  1.000 35.92563 ?  382 TRP A CD2   1 
ATOM   2060 N NE1   . TRP A 1 264 ? -66.15312 8.32213   -6.66528  1.000 37.80058 ?  382 TRP A NE1   1 
ATOM   2061 C CE2   . TRP A 1 264 ? -64.82523 8.51346   -6.38333  1.000 37.87320 ?  382 TRP A CE2   1 
ATOM   2062 C CE3   . TRP A 1 264 ? -63.49222 9.57649   -4.67358  1.000 35.26699 ?  382 TRP A CE3   1 
ATOM   2063 C CZ2   . TRP A 1 264 ? -63.68136 8.08189   -7.07917  1.000 36.31980 ?  382 TRP A CZ2   1 
ATOM   2064 C CZ3   . TRP A 1 264 ? -62.35643 9.14971   -5.36761  1.000 35.63343 ?  382 TRP A CZ3   1 
ATOM   2065 C CH2   . TRP A 1 264 ? -62.46495 8.41062   -6.55808  1.000 33.87800 ?  382 TRP A CH2   1 
ATOM   2066 N N     . ILE A 1 265 ? -64.85407 9.08177   -1.08580  1.000 38.43764 ?  383 ILE A N     1 
ATOM   2067 C CA    . ILE A 1 265 ? -63.73340 8.29443   -0.57685  1.000 38.77544 ?  383 ILE A CA    1 
ATOM   2068 C C     . ILE A 1 265 ? -64.22629 7.15725   0.31297   1.000 40.04118 ?  383 ILE A C     1 
ATOM   2069 O O     . ILE A 1 265 ? -63.82823 5.99703   0.15100   1.000 39.01309 ?  383 ILE A O     1 
ATOM   2070 C CB    . ILE A 1 265 ? -62.74412 9.20635   0.16316   1.000 36.00891 ?  383 ILE A CB    1 
ATOM   2071 C CG1   . ILE A 1 265 ? -62.05871 10.12959  -0.85073  1.000 36.66182 ?  383 ILE A CG1   1 
ATOM   2072 C CG2   . ILE A 1 265 ? -61.75988 8.36708   0.99183   1.000 36.70253 ?  383 ILE A CG2   1 
ATOM   2073 C CD1   . ILE A 1 265 ? -61.11478 9.39327   -1.80302  1.000 35.02450 ?  383 ILE A CD1   1 
ATOM   2074 N N     . THR A 1 266 ? -65.08620 7.47039   1.27718   1.000 40.04421 ?  384 THR A N     1 
ATOM   2075 C CA    . THR A 1 266 ? -65.55203 6.43432   2.19588   1.000 44.23336 ?  384 THR A CA    1 
ATOM   2076 C C     . THR A 1 266 ? -66.43989 5.39900   1.50355   1.000 42.46209 ?  384 THR A C     1 
ATOM   2077 O O     . THR A 1 266 ? -66.43181 4.22626   1.89442   1.000 44.71835 ?  384 THR A O     1 
ATOM   2078 C CB    . THR A 1 266 ? -66.28746 7.07519   3.37170   1.000 38.36303 ?  384 THR A CB    1 
ATOM   2079 O OG1   . THR A 1 266 ? -67.45820 7.72014   2.88520   1.000 44.14071 ?  384 THR A OG1   1 
ATOM   2080 C CG2   . THR A 1 266 ? -65.41110 8.08525   4.06513   1.000 44.46118 ?  384 THR A CG2   1 
ATOM   2081 N N     . ALA A 1 267 ? -67.18283 5.79190   0.46633   1.000 40.70383 ?  385 ALA A N     1 
ATOM   2082 C CA    . ALA A 1 267 ? -68.01461 4.82223   -0.24405  1.000 43.72474 ?  385 ALA A CA    1 
ATOM   2083 C C     . ALA A 1 267 ? -67.19050 3.83288   -1.06318  1.000 45.97767 ?  385 ALA A C     1 
ATOM   2084 O O     . ALA A 1 267 ? -67.64294 2.70695   -1.30010  1.000 44.40197 ?  385 ALA A O     1 
ATOM   2085 C CB    . ALA A 1 267 ? -69.00634 5.53599   -1.16079  1.000 42.32028 ?  385 ALA A CB    1 
ATOM   2086 N N     . ASN A 1 268 ? -65.99624 4.22369   -1.51733  1.000 40.84436 ?  386 ASN A N     1 
ATOM   2087 C CA    . ASN A 1 268 ? -65.26252 3.43006   -2.49655  1.000 39.85866 ?  386 ASN A CA    1 
ATOM   2088 C C     . ASN A 1 268 ? -63.91923 2.89216   -2.02186  1.000 40.51110 ?  386 ASN A C     1 
ATOM   2089 O O     . ASN A 1 268 ? -63.39745 1.96358   -2.64639  1.000 43.20011 ?  386 ASN A O     1 
ATOM   2090 C CB    . ASN A 1 268 ? -65.01680 4.25636   -3.76568  1.000 37.57165 ?  386 ASN A CB    1 
ATOM   2091 C CG    . ASN A 1 268 ? -66.29929 4.59185   -4.49313  1.000 41.59393 ?  386 ASN A CG    1 
ATOM   2092 O OD1   . ASN A 1 268 ? -66.77064 5.73735   -4.47834  1.000 43.05894 ?  386 ASN A OD1   1 
ATOM   2093 N ND2   . ASN A 1 268 ? -66.89020 3.58645   -5.11007  1.000 41.50056 ?  386 ASN A ND2   1 
ATOM   2094 N N     . SER A 1 269 ? -63.33602 3.44013   -0.96355  1.000 39.86799 ?  387 SER A N     1 
ATOM   2095 C CA    . SER A 1 269 ? -62.00310 3.00889   -0.56921  1.000 40.82021 ?  387 SER A CA    1 
ATOM   2096 C C     . SER A 1 269 ? -62.03897 1.67166   0.16807   1.000 47.16842 ?  387 SER A C     1 
ATOM   2097 O O     . SER A 1 269 ? -62.98188 1.36021   0.90305   1.000 47.96855 ?  387 SER A O     1 
ATOM   2098 C CB    . SER A 1 269 ? -61.33537 4.05713   0.31437   1.000 42.54703 ?  387 SER A CB    1 
ATOM   2099 O OG    . SER A 1 269 ? -60.20247 3.51499   0.97590   1.000 45.84434 ?  387 SER A OG    1 
ATOM   2100 N N     . SER A 1 270 ? -60.98727 0.88613   -0.03512  1.000 46.57636 ?  388 SER A N     1 
ATOM   2101 C CA    . SER A 1 270 ? -60.76382 -0.34702  0.71082   1.000 51.99968 ?  388 SER A CA    1 
ATOM   2102 C C     . SER A 1 270 ? -60.23500 -0.01258  2.10165   1.000 54.51822 ?  388 SER A C     1 
ATOM   2103 O O     . SER A 1 270 ? -60.41183 -0.78814  3.04272   1.000 63.60603 ?  388 SER A O     1 
ATOM   2104 C CB    . SER A 1 270 ? -59.77297 -1.25447  -0.02703  1.000 52.47043 ?  388 SER A CB    1 
ATOM   2105 O OG    . SER A 1 270 ? -60.27591 -1.62706  -1.30289  1.000 58.86143 ?  388 SER A OG    1 
HETATM 2106 N N1    . OG0 B 2 .   ? -37.71069 7.52949   -7.46052  1.000 30.82204 ?  501 OG0 A N1    1 
HETATM 2107 N N3    . OG0 B 2 .   ? -37.79102 0.85013   -5.78216  1.000 30.47176 ?  501 OG0 A N3    1 
HETATM 2108 C C5    . OG0 B 2 .   ? -36.87623 5.20611   -6.91430  1.000 30.03923 ?  501 OG0 A C5    1 
HETATM 2109 C C6    . OG0 B 2 .   ? -36.58494 6.68630   -7.11042  1.000 28.08677 ?  501 OG0 A C6    1 
HETATM 2110 C C7    . OG0 B 2 .   ? -38.08290 0.80593   -7.11272  1.000 32.68068 ?  501 OG0 A C7    1 
HETATM 2111 C C8    . OG0 B 2 .   ? -37.36734 1.97483   -5.20759  1.000 33.32932 ?  501 OG0 A C8    1 
HETATM 2112 C C10   . OG0 B 2 .   ? -36.82168 4.46646   -5.75281  1.000 28.90182 ?  501 OG0 A C10   1 
HETATM 2113 C C13   . OG0 B 2 .   ? -36.52088 3.83640   -10.18555 1.000 29.11631 ?  501 OG0 A C13   1 
HETATM 2114 C C15   . OG0 B 2 .   ? -38.69904 3.85018   -11.35951 1.000 32.36322 ?  501 OG0 A C15   1 
HETATM 2115 C C17   . OG0 B 2 .   ? -37.53917 3.01870   -7.32273  1.000 29.50989 ?  501 OG0 A C17   1 
HETATM 2116 C C20   . OG0 B 2 .   ? -39.07871 7.05041   -7.61109  1.000 28.99730 ?  501 OG0 A C20   1 
HETATM 2117 C C21   . OG0 B 2 .   ? -38.82603 0.30983   -10.13137 1.000 32.86227 ?  501 OG0 A C21   1 
HETATM 2118 C C1    . OG0 B 2 .   ? -40.52984 -3.56345  -14.67947 1.000 45.12208 ?  501 OG0 A C1    1 
HETATM 2119 C "C1'" . OG0 B 2 .   ? -38.94338 -0.71440  -9.01120  1.000 32.18085 ?  501 OG0 A "C1'" 1 
HETATM 2120 C C12   . OG0 B 2 .   ? -37.53657 4.59734   -9.32749  1.000 29.72060 ?  501 OG0 A C12   1 
HETATM 2121 C C14   . OG0 B 2 .   ? -37.15798 3.87043   -11.57127 1.000 31.86930 ?  501 OG0 A C14   1 
HETATM 2122 C C16   . OG0 B 2 .   ? -38.92271 4.24036   -9.86670  1.000 31.05654 ?  501 OG0 A C16   1 
HETATM 2123 C C19   . OG0 B 2 .   ? -37.48320 8.95874   -7.67358  1.000 29.40519 ?  501 OG0 A C19   1 
HETATM 2124 C C2    . OG0 B 2 .   ? -40.13906 -1.74402  -13.02319 1.000 37.20429 ?  501 OG0 A C2    1 
HETATM 2125 C "C2'" . OG0 B 2 .   ? -39.38734 -1.93359  -9.23929  1.000 33.35986 ?  501 OG0 A "C2'" 1 
HETATM 2126 C "C3'" . OG0 B 2 .   ? -39.81758 -2.29560  -10.64930 1.000 33.37857 ?  501 OG0 A "C3'" 1 
HETATM 2127 C "C4'" . OG0 B 2 .   ? -39.72884 -1.38519  -11.61215 1.000 33.08761 ?  501 OG0 A "C4'" 1 
HETATM 2128 C "C5'" . OG0 B 2 .   ? -39.19572 -0.00080  -11.34957 1.000 32.98575 ?  501 OG0 A "C5'" 1 
HETATM 2129 C C9    . OG0 B 2 .   ? -37.21437 3.09752   -5.96799  1.000 29.13904 ?  501 OG0 A C9    1 
HETATM 2130 N N2    . OG0 B 2 .   ? -40.15488 -3.15653  -13.33640 1.000 38.91746 ?  501 OG0 A N2    1 
HETATM 2131 N N5    . OG0 B 2 .   ? -37.94127 1.90729   -7.87496  1.000 29.54805 ?  501 OG0 A N5    1 
HETATM 2132 N N7    . OG0 B 2 .   ? -37.34199 4.30509   -7.87922  1.000 28.74942 ?  501 OG0 A N7    1 
HETATM 2133 N N9    . OG0 B 2 .   ? -38.52778 -0.42831  -7.67171  1.000 31.06259 ?  501 OG0 A N9    1 
HETATM 2134 O O6    . OG0 B 2 .   ? -35.50966 7.14803   -6.97180  1.000 33.37354 ?  501 OG0 A O6    1 
HETATM 2135 O OP3   . OG0 B 2 .   ? -40.39955 -0.90180  -13.83486 1.000 35.44556 ?  501 OG0 A OP3   1 
HETATM 2136 O O     . HOH C 3 .   ? -35.31153 3.91615   8.42288   1.000 58.29640 ?  601 HOH A O     1 
HETATM 2137 O O     . HOH C 3 .   ? -18.49144 4.61159   3.41754   1.000 54.24463 ?  602 HOH A O     1 
HETATM 2138 O O     . HOH C 3 .   ? -46.91486 9.18877   -20.20926 1.000 44.45221 ?  603 HOH A O     1 
HETATM 2139 O O     . HOH C 3 .   ? -47.89625 15.77146  -19.73297 1.000 45.31827 ?  604 HOH A O     1 
HETATM 2140 O O     . HOH C 3 .   ? -51.92630 2.95539   -21.47801 1.000 50.79842 ?  605 HOH A O     1 
HETATM 2141 O O     . HOH C 3 .   ? -39.10035 17.46722  -10.95819 1.000 47.25585 ?  606 HOH A O     1 
HETATM 2142 O O     . HOH C 3 .   ? -43.55068 2.33849   -22.36661 1.000 50.87699 ?  607 HOH A O     1 
HETATM 2143 O O     . HOH C 3 .   ? -40.74289 -0.54665  -16.41419 1.000 43.43699 ?  608 HOH A O     1 
HETATM 2144 O O     . HOH C 3 .   ? -43.97417 29.78289  -4.47760  1.000 55.99738 ?  609 HOH A O     1 
HETATM 2145 O O     . HOH C 3 .   ? -53.64783 28.83944  2.21387   1.000 44.92147 ?  610 HOH A O     1 
HETATM 2146 O O     . HOH C 3 .   ? -23.75862 17.32759  -16.95454 1.000 52.32442 ?  611 HOH A O     1 
HETATM 2147 O O     . HOH C 3 .   ? -69.37259 3.21164   -5.28901  1.000 57.54286 ?  612 HOH A O     1 
HETATM 2148 O O     . HOH C 3 .   ? -61.04192 -2.16776  5.07007   1.000 68.85996 ?  613 HOH A O     1 
HETATM 2149 O O     . HOH C 3 .   ? -67.08671 21.14386  -10.64748 1.000 43.96510 ?  614 HOH A O     1 
HETATM 2150 O O     . HOH C 3 .   ? -49.29385 12.37753  -19.83931 1.000 44.40940 ?  615 HOH A O     1 
HETATM 2151 O O     . HOH C 3 .   ? -51.98291 -1.64281  -5.85293  1.000 39.59391 ?  616 HOH A O     1 
HETATM 2152 O O     . HOH C 3 .   ? -54.69109 15.39340  -22.56837 1.000 49.44580 ?  617 HOH A O     1 
HETATM 2153 O O     . HOH C 3 .   ? -47.35396 18.33017  -3.60728  1.000 36.12077 ?  618 HOH A O     1 
HETATM 2154 O O     . HOH C 3 .   ? -42.87374 3.42542   -16.89978 1.000 38.24814 ?  619 HOH A O     1 
HETATM 2155 O O     . HOH C 3 .   ? -53.37322 6.18782   -19.07805 1.000 42.52851 ?  620 HOH A O     1 
HETATM 2156 O O     . HOH C 3 .   ? -65.37233 15.51392  3.87356   1.000 45.62692 ?  621 HOH A O     1 
HETATM 2157 O O     . HOH C 3 .   ? -42.06976 12.72917  -14.74530 1.000 36.75853 ?  622 HOH A O     1 
HETATM 2158 O O     . HOH C 3 .   ? -40.12192 6.98282   -11.86155 1.000 30.62579 ?  623 HOH A O     1 
HETATM 2159 O O     . HOH C 3 .   ? -51.03796 8.91209   -17.49487 1.000 46.28057 ?  624 HOH A O     1 
HETATM 2160 O O     . HOH C 3 .   ? -57.97844 23.21831  -24.84511 1.000 57.09915 ?  625 HOH A O     1 
HETATM 2161 O O     . HOH C 3 .   ? -37.03653 6.99615   6.13405   1.000 44.89111 ?  626 HOH A O     1 
HETATM 2162 O O     . HOH C 3 .   ? -60.12787 8.79796   -20.28952 1.000 47.34024 ?  627 HOH A O     1 
HETATM 2163 O O     . HOH C 3 .   ? -39.44599 9.90131   -10.87763 1.000 33.70243 ?  628 HOH A O     1 
HETATM 2164 O O     . HOH C 3 .   ? -45.89369 -0.81947  -11.81955 1.000 36.56470 ?  629 HOH A O     1 
HETATM 2165 O O     . HOH C 3 .   ? -54.26804 31.24223  1.25426   1.000 52.88120 ?  630 HOH A O     1 
HETATM 2166 O O     . HOH C 3 .   ? -19.44106 13.36510  -9.50895  1.000 48.69855 ?  631 HOH A O     1 
HETATM 2167 O O     . HOH C 3 .   ? -56.01435 18.96658  -21.11411 1.000 42.93822 ?  632 HOH A O     1 
HETATM 2168 O O     . HOH C 3 .   ? -39.68364 14.92598  -8.53197  1.000 42.37269 ?  633 HOH A O     1 
HETATM 2169 O O     . HOH C 3 .   ? -67.20020 24.16972  -4.09196  1.000 59.58896 ?  634 HOH A O     1 
HETATM 2170 O O     . HOH C 3 .   ? -58.57838 -0.28264  -14.18126 1.000 47.93097 ?  635 HOH A O     1 
HETATM 2171 O O     . HOH C 3 .   ? -53.20865 29.93547  -6.13009  1.000 40.84244 ?  636 HOH A O     1 
HETATM 2172 O O     . HOH C 3 .   ? -68.54298 15.77356  -18.64836 1.000 42.22455 ?  637 HOH A O     1 
HETATM 2173 O O     . HOH C 3 .   ? -38.63487 -4.65042  -0.47402  1.000 45.56676 ?  638 HOH A O     1 
HETATM 2174 O O     . HOH C 3 .   ? -53.01529 -0.12612  -2.13558  1.000 45.77271 ?  639 HOH A O     1 
HETATM 2175 O O     . HOH C 3 .   ? -51.14286 16.76537  9.84596   1.000 42.48298 ?  640 HOH A O     1 
HETATM 2176 O O     . HOH C 3 .   ? -53.63881 34.80570  -22.55176 1.000 59.58702 ?  641 HOH A O     1 
HETATM 2177 O O     . HOH C 3 .   ? -62.01107 5.56887   -14.11288 1.000 35.29326 ?  642 HOH A O     1 
HETATM 2178 O O     . HOH C 3 .   ? -57.00647 29.89524  -21.83906 1.000 50.58494 ?  643 HOH A O     1 
HETATM 2179 O O     . HOH C 3 .   ? -37.73249 -5.37206  -10.61346 1.000 46.92617 ?  644 HOH A O     1 
HETATM 2180 O O     . HOH C 3 .   ? -50.860   29.974    4.648     1.000 35.42965 ?  645 HOH A O     1 
HETATM 2181 O O     . HOH C 3 .   ? -42.20289 2.20228   3.88538   1.000 35.89310 ?  646 HOH A O     1 
HETATM 2182 O O     . HOH C 3 .   ? -30.61293 -6.99136  -12.08367 1.000 42.79378 ?  647 HOH A O     1 
HETATM 2183 O O     . HOH C 3 .   ? -41.20551 5.36548   5.94102   1.000 37.91845 ?  648 HOH A O     1 
HETATM 2184 O O     . HOH C 3 .   ? -36.84477 -0.76823  -14.36801 1.000 41.18629 ?  649 HOH A O     1 
HETATM 2185 O O     . HOH C 3 .   ? -41.17304 20.68004  3.60686   1.000 48.98531 ?  650 HOH A O     1 
HETATM 2186 O O     . HOH C 3 .   ? -50.16074 27.16806  -1.10780  1.000 37.77622 ?  651 HOH A O     1 
HETATM 2187 O O     . HOH C 3 .   ? -26.85549 -12.78535 -5.81461  1.000 42.53428 ?  652 HOH A O     1 
HETATM 2188 O O     . HOH C 3 .   ? -42.22310 3.65064   -14.37098 1.000 30.00843 ?  653 HOH A O     1 
HETATM 2189 O O     . HOH C 3 .   ? -42.92157 -4.09709  0.06770   1.000 48.72288 ?  654 HOH A O     1 
HETATM 2190 O O     . HOH C 3 .   ? -51.07744 0.96535   2.99764   1.000 51.53497 ?  655 HOH A O     1 
HETATM 2191 O O     . HOH C 3 .   ? -39.84458 -5.61017  -12.08446 1.000 45.32314 ?  656 HOH A O     1 
HETATM 2192 O O     . HOH C 3 .   ? -41.57153 -1.88505  -0.58319  1.000 36.99266 ?  657 HOH A O     1 
HETATM 2193 O O     . HOH C 3 .   ? -51.19817 21.13916  -11.85093 1.000 29.97113 ?  658 HOH A O     1 
HETATM 2194 O O     . HOH C 3 .   ? -45.03592 18.49763  -9.09312  1.000 41.36394 ?  659 HOH A O     1 
HETATM 2195 O O     . HOH C 3 .   ? -34.09634 13.93220  -12.34286 1.000 44.02517 ?  660 HOH A O     1 
HETATM 2196 O O     . HOH C 3 .   ? -42.09426 -5.41148  -10.92691 1.000 46.24679 ?  661 HOH A O     1 
HETATM 2197 O O     . HOH C 3 .   ? -68.15551 9.93820   4.76141   1.000 49.31219 ?  662 HOH A O     1 
HETATM 2198 O O     . HOH C 3 .   ? -30.012   -14.133   -2.869    1.000 53.35764 ?  663 HOH A O     1 
HETATM 2199 O O     . HOH C 3 .   ? -70.61160 9.44850   -7.39687  1.000 44.79903 ?  664 HOH A O     1 
HETATM 2200 O O     . HOH C 3 .   ? -65.42933 8.53131   -11.38497 1.000 37.81048 ?  665 HOH A O     1 
HETATM 2201 O O     . HOH C 3 .   ? -70.67883 16.56561  -8.67644  1.000 50.39957 ?  666 HOH A O     1 
HETATM 2202 O O     . HOH C 3 .   ? -56.80092 21.54236  -19.83815 1.000 39.17279 ?  667 HOH A O     1 
HETATM 2203 O O     . HOH C 3 .   ? -42.03518 1.16978   -12.83568 1.000 31.07996 ?  668 HOH A O     1 
HETATM 2204 O O     . HOH C 3 .   ? -52.46978 19.17582  6.90380   1.000 44.94394 ?  669 HOH A O     1 
HETATM 2205 O O     . HOH C 3 .   ? -20.94682 -11.07511 -3.04394  1.000 44.41355 ?  670 HOH A O     1 
HETATM 2206 O O     . HOH C 3 .   ? -34.87787 -9.06437  0.47186   1.000 49.88576 ?  671 HOH A O     1 
HETATM 2207 O O     . HOH C 3 .   ? -48.62725 19.36536  -20.61181 1.000 47.79432 ?  672 HOH A O     1 
HETATM 2208 O O     . HOH C 3 .   ? -54.91431 19.19988  6.33395   1.000 40.55389 ?  673 HOH A O     1 
HETATM 2209 O O     . HOH C 3 .   ? -55.98861 29.12427  4.54607   1.000 50.74582 ?  674 HOH A O     1 
HETATM 2210 O O     . HOH C 3 .   ? -57.92555 31.25274  -12.05731 1.000 44.16494 ?  675 HOH A O     1 
HETATM 2211 O O     . HOH C 3 .   ? -17.84613 3.12619   -0.71485  1.000 51.96818 ?  676 HOH A O     1 
HETATM 2212 O O     . HOH C 3 .   ? -34.10590 4.52403   -17.54024 1.000 38.91608 ?  677 HOH A O     1 
HETATM 2213 O O     . HOH C 3 .   ? -56.10377 16.35848  -20.19732 1.000 42.76917 ?  678 HOH A O     1 
HETATM 2214 O O     . HOH C 3 .   ? -36.88109 7.99700   -3.57767  1.000 37.25026 ?  679 HOH A O     1 
HETATM 2215 O O     . HOH C 3 .   ? -17.42724 5.04161   0.96162   1.000 50.34536 ?  680 HOH A O     1 
HETATM 2216 O O     . HOH C 3 .   ? -67.75618 2.42840   -9.54811  1.000 51.77740 ?  681 HOH A O     1 
HETATM 2217 O O     . HOH C 3 .   ? -47.13255 5.83092   -21.86868 1.000 42.98435 ?  682 HOH A O     1 
HETATM 2218 O O     . HOH C 3 .   ? -59.185   18.792    -18.828   1.000 36.11069 ?  683 HOH A O     1 
HETATM 2219 O O     . HOH C 3 .   ? -24.02018 -14.23759 -4.78011  1.000 45.08276 ?  684 HOH A O     1 
HETATM 2220 O O     . HOH C 3 .   ? -41.71130 18.95974  -4.62820  1.000 50.09628 ?  685 HOH A O     1 
HETATM 2221 O O     . HOH C 3 .   ? -36.03371 -3.01538  0.53293   1.000 36.12470 ?  686 HOH A O     1 
HETATM 2222 O O     . HOH C 3 .   ? -46.39056 19.87665  -23.37802 1.000 51.36892 ?  687 HOH A O     1 
HETATM 2223 O O     . HOH C 3 .   ? -51.89873 18.44774  -15.59708 1.000 34.12031 ?  688 HOH A O     1 
HETATM 2224 O O     . HOH C 3 .   ? -40.45509 5.83920   -14.37821 1.000 29.86746 ?  689 HOH A O     1 
HETATM 2225 O O     . HOH C 3 .   ? -58.41079 -0.30134  -11.30737 1.000 36.61699 ?  690 HOH A O     1 
HETATM 2226 O O     . HOH C 3 .   ? -37.09116 15.84125  -9.66135  1.000 40.42500 ?  691 HOH A O     1 
HETATM 2227 O O     . HOH C 3 .   ? -32.43240 12.14361  -9.49774  1.000 43.67629 ?  692 HOH A O     1 
HETATM 2228 O O     . HOH C 3 .   ? -36.81799 -6.38869  -0.46082  1.000 49.75158 ?  693 HOH A O     1 
HETATM 2229 O O     . HOH C 3 .   ? -61.01395 27.87908  -8.61796  1.000 39.35928 ?  694 HOH A O     1 
HETATM 2230 O O     . HOH C 3 .   ? -19.264   -9.709    -3.737    1.000 46.90893 ?  695 HOH A O     1 
HETATM 2231 O O     . HOH C 3 .   ? -46.94104 16.86380  -6.90217  1.000 37.62873 ?  696 HOH A O     1 
HETATM 2232 O O     . HOH C 3 .   ? -62.49479 29.46503  -4.00034  1.000 57.38196 ?  697 HOH A O     1 
HETATM 2233 O O     . HOH C 3 .   ? -40.54972 17.88918  1.25673   1.000 52.23485 ?  698 HOH A O     1 
HETATM 2234 O O     . HOH C 3 .   ? -60.74336 29.24666  -5.72609  1.000 39.49033 ?  699 HOH A O     1 
HETATM 2235 O O     . HOH C 3 .   ? -69.60332 6.36379   -5.21060  1.000 50.90982 ?  700 HOH A O     1 
HETATM 2236 O O     . HOH C 3 .   ? -58.56139 14.85834  -20.20735 1.000 49.48252 ?  701 HOH A O     1 
HETATM 2237 O O     . HOH C 3 .   ? -65.10599 2.23157   -11.24236 1.000 49.74901 ?  702 HOH A O     1 
HETATM 2238 O O     . HOH C 3 .   ? -17.50967 -9.72416  -0.98512  1.000 59.55910 ?  703 HOH A O     1 
HETATM 2239 O O     . HOH C 3 .   ? -16.24306 0.14260   -0.81928  1.000 51.39873 ?  704 HOH A O     1 
HETATM 2240 O O     . HOH C 3 .   ? -19.32521 7.52387   3.59801   1.000 45.92515 ?  705 HOH A O     1 
HETATM 2241 O O     . HOH C 3 .   ? -51.43163 7.56136   8.97129   1.000 49.94109 ?  706 HOH A O     1 
HETATM 2242 O O     . HOH C 3 .   ? -39.72139 9.80826   -0.17744  1.000 37.87242 ?  707 HOH A O     1 
HETATM 2243 O O     . HOH C 3 .   ? -46.22963 20.02750  -7.19618  1.000 46.09734 ?  708 HOH A O     1 
HETATM 2244 O O     . HOH C 3 .   ? -39.32289 10.67960  -13.80378 1.000 42.63867 ?  709 HOH A O     1 
HETATM 2245 O O     . HOH C 3 .   ? -37.12765 14.99473  -0.69886  1.000 49.12914 ?  710 HOH A O     1 
HETATM 2246 O O     . HOH C 3 .   ? -55.10109 33.05263  -0.35882  1.000 54.25977 ?  711 HOH A O     1 
HETATM 2247 O O     . HOH C 3 .   ? -48.05061 -2.31663  -12.55381 1.000 46.14995 ?  712 HOH A O     1 
HETATM 2248 O O     . HOH C 3 .   ? -50.70506 -3.54197  -7.32549  1.000 47.85223 ?  713 HOH A O     1 
HETATM 2249 O O     . HOH C 3 .   ? -40.18342 -0.80628  6.15475   1.000 59.42084 ?  714 HOH A O     1 
HETATM 2250 O O     . HOH C 3 .   ? -41.17313 -6.05007  -0.08721  1.000 53.80987 ?  715 HOH A O     1 
HETATM 2251 O O     . HOH C 3 .   ? -49.72824 6.45235   -18.61273 1.000 50.56001 ?  716 HOH A O     1 
HETATM 2252 O O     . HOH C 3 .   ? -15.93836 -0.69613  -3.46284  1.000 55.01375 ?  717 HOH A O     1 
HETATM 2253 O O     . HOH C 3 .   ? -64.59314 6.51134   -13.12808 1.000 42.69626 ?  718 HOH A O     1 
HETATM 2254 O O     . HOH C 3 .   ? -68.86538 -1.20498  -6.49092  1.000 62.05396 ?  719 HOH A O     1 
HETATM 2255 O O     . HOH C 3 .   ? -67.26662 22.18313  -5.10658  1.000 56.27710 ?  720 HOH A O     1 
HETATM 2256 O O     . HOH C 3 .   ? -45.25824 -1.70766  5.46835   1.000 64.70693 ?  721 HOH A O     1 
HETATM 2257 O O     . HOH C 3 .   ? -32.23121 2.65587   -16.69379 1.000 39.91335 ?  722 HOH A O     1 
HETATM 2258 O O     . HOH C 3 .   ? -38.223   -6.127    -15.876   1.000 50.29302 ?  723 HOH A O     1 
HETATM 2259 O O     . HOH C 3 .   ? -46.393   -10.473   -0.634    1.000 63.02563 ?  724 HOH A O     1 
HETATM 2260 O O     . HOH C 3 .   ? -69.39145 0.79616   -8.20582  1.000 60.64591 ?  725 HOH A O     1 
HETATM 2261 O O     . HOH C 3 .   ? -42.42043 0.78077   6.02930   1.000 50.39331 ?  726 HOH A O     1 
HETATM 2262 O O     . HOH C 3 .   ? -37.426   10.395    -20.855   1.000 52.26317 ?  727 HOH A O     1 
HETATM 2263 O O     . HOH C 3 .   ? -34.38758 16.15855  -11.85902 1.000 44.19311 ?  728 HOH A O     1 
HETATM 2264 O O     . HOH C 3 .   ? -15.74205 2.20834   -4.69874  1.000 57.75930 ?  729 HOH A O     1 
HETATM 2265 O O     . HOH C 3 .   ? -48.920   32.072    4.440     1.000 52.42310 ?  730 HOH A O     1 
HETATM 2266 O O     . HOH C 3 .   ? -65.56737 0.11247   -13.18525 1.000 63.61094 ?  731 HOH A O     1 
HETATM 2267 O O     . HOH C 3 .   ? -30.338   26.834    0.690     1.000 69.17830 ?  732 HOH A O     1 
# 
