data_9BYU
# 
_entry.id   9BYU 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BYU         pdb_00009byu 10.2210/pdb9byu/pdb 
WWPDB D_1000284398 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2024-11-06 
2 'Structure model' 1 1 2024-11-27 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation_author.identifier_ORCID' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BYU 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-24 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              raquel.lieberman@chemistry.gatech.edu 
_pdbx_contact_author.name_first         Raquel 
_pdbx_contact_author.name_last          Lieberman 
_pdbx_contact_author.name_mi            L 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-9345-3735 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Thomas, G.M.'    1 ? 
'Quirk, S.'       2 ? 
'Huard, D.J.E.'   3 ? 
'Lieberman, R.L.' 4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Acta Crystallogr D Struct Biol' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2059-7983 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            80 
_citation.language                  ? 
_citation.page_first                791 
_citation.page_last                 799 
_citation.title                     'Structure and stability of an apo thermophilic esterase that hydrolyzes polyhydroxybutyrate.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1107/S2059798324009707 
_citation.pdbx_database_id_PubMed   39441250 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Thomas, G.M.'    1 ? 
primary 'Quirk, S.'       2 ? 
primary 'Lieberman, R.L.' 3 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Esterase, PHB depolymerase family'      32441.875 1   ? ? ? ? 
2 non-polymer syn 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL 122.143   1   ? ? ? ? 
3 non-polymer syn 'MAGNESIUM ION'                          24.305    1   ? ? ? ? 
4 water       nat water                                    18.015    261 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Polyhydroxybutyrate Depolymerase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GPAGQFIRDTAPDGRVYKLYIPSGYNGSTPLPLVVMLHGCTQNPDDFAAGTEMNVYAEQNNFLVAYPEQPSSANLNKCWN
WFDSNHQSRGRGEPASIAGVVEDVKRNYSVDSRRVYAAGLSAGGAMSVIMGATYPDVFAAIGVGSGLEYKAATSMTSAYM
AMINGGPDPVQQGNLAYQAMGSHARVVPVIVFHGTSDYTVYPVNGHQVISQWAQTNDRAGDGVDNNHIDDQADVTMNGSV
PNGRTYTRYLYKDQNGNVVMEKIMVNGMGHAWSGGSTAGTYTDPAGPEASSMMWSFFVNHPK
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GPAGQFIRDTAPDGRVYKLYIPSGYNGSTPLPLVVMLHGCTQNPDDFAAGTEMNVYAEQNNFLVAYPEQPSSANLNKCWN
WFDSNHQSRGRGEPASIAGVVEDVKRNYSVDSRRVYAAGLSAGGAMSVIMGATYPDVFAAIGVGSGLEYKAATSMTSAYM
AMINGGPDPVQQGNLAYQAMGSHARVVPVIVFHGTSDYTVYPVNGHQVISQWAQTNDRAGDGVDNNHIDDQADVTMNGSV
PNGRTYTRYLYKDQNGNVVMEKIMVNGMGHAWSGGSTAGTYTDPAGPEASSMMWSFFVNHPK
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL TRS 
3 'MAGNESIUM ION'                          MG  
4 water                                    HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PRO n 
1 3   ALA n 
1 4   GLY n 
1 5   GLN n 
1 6   PHE n 
1 7   ILE n 
1 8   ARG n 
1 9   ASP n 
1 10  THR n 
1 11  ALA n 
1 12  PRO n 
1 13  ASP n 
1 14  GLY n 
1 15  ARG n 
1 16  VAL n 
1 17  TYR n 
1 18  LYS n 
1 19  LEU n 
1 20  TYR n 
1 21  ILE n 
1 22  PRO n 
1 23  SER n 
1 24  GLY n 
1 25  TYR n 
1 26  ASN n 
1 27  GLY n 
1 28  SER n 
1 29  THR n 
1 30  PRO n 
1 31  LEU n 
1 32  PRO n 
1 33  LEU n 
1 34  VAL n 
1 35  VAL n 
1 36  MET n 
1 37  LEU n 
1 38  HIS n 
1 39  GLY n 
1 40  CYS n 
1 41  THR n 
1 42  GLN n 
1 43  ASN n 
1 44  PRO n 
1 45  ASP n 
1 46  ASP n 
1 47  PHE n 
1 48  ALA n 
1 49  ALA n 
1 50  GLY n 
1 51  THR n 
1 52  GLU n 
1 53  MET n 
1 54  ASN n 
1 55  VAL n 
1 56  TYR n 
1 57  ALA n 
1 58  GLU n 
1 59  GLN n 
1 60  ASN n 
1 61  ASN n 
1 62  PHE n 
1 63  LEU n 
1 64  VAL n 
1 65  ALA n 
1 66  TYR n 
1 67  PRO n 
1 68  GLU n 
1 69  GLN n 
1 70  PRO n 
1 71  SER n 
1 72  SER n 
1 73  ALA n 
1 74  ASN n 
1 75  LEU n 
1 76  ASN n 
1 77  LYS n 
1 78  CYS n 
1 79  TRP n 
1 80  ASN n 
1 81  TRP n 
1 82  PHE n 
1 83  ASP n 
1 84  SER n 
1 85  ASN n 
1 86  HIS n 
1 87  GLN n 
1 88  SER n 
1 89  ARG n 
1 90  GLY n 
1 91  ARG n 
1 92  GLY n 
1 93  GLU n 
1 94  PRO n 
1 95  ALA n 
1 96  SER n 
1 97  ILE n 
1 98  ALA n 
1 99  GLY n 
1 100 VAL n 
1 101 VAL n 
1 102 GLU n 
1 103 ASP n 
1 104 VAL n 
1 105 LYS n 
1 106 ARG n 
1 107 ASN n 
1 108 TYR n 
1 109 SER n 
1 110 VAL n 
1 111 ASP n 
1 112 SER n 
1 113 ARG n 
1 114 ARG n 
1 115 VAL n 
1 116 TYR n 
1 117 ALA n 
1 118 ALA n 
1 119 GLY n 
1 120 LEU n 
1 121 SER n 
1 122 ALA n 
1 123 GLY n 
1 124 GLY n 
1 125 ALA n 
1 126 MET n 
1 127 SER n 
1 128 VAL n 
1 129 ILE n 
1 130 MET n 
1 131 GLY n 
1 132 ALA n 
1 133 THR n 
1 134 TYR n 
1 135 PRO n 
1 136 ASP n 
1 137 VAL n 
1 138 PHE n 
1 139 ALA n 
1 140 ALA n 
1 141 ILE n 
1 142 GLY n 
1 143 VAL n 
1 144 GLY n 
1 145 SER n 
1 146 GLY n 
1 147 LEU n 
1 148 GLU n 
1 149 TYR n 
1 150 LYS n 
1 151 ALA n 
1 152 ALA n 
1 153 THR n 
1 154 SER n 
1 155 MET n 
1 156 THR n 
1 157 SER n 
1 158 ALA n 
1 159 TYR n 
1 160 MET n 
1 161 ALA n 
1 162 MET n 
1 163 ILE n 
1 164 ASN n 
1 165 GLY n 
1 166 GLY n 
1 167 PRO n 
1 168 ASP n 
1 169 PRO n 
1 170 VAL n 
1 171 GLN n 
1 172 GLN n 
1 173 GLY n 
1 174 ASN n 
1 175 LEU n 
1 176 ALA n 
1 177 TYR n 
1 178 GLN n 
1 179 ALA n 
1 180 MET n 
1 181 GLY n 
1 182 SER n 
1 183 HIS n 
1 184 ALA n 
1 185 ARG n 
1 186 VAL n 
1 187 VAL n 
1 188 PRO n 
1 189 VAL n 
1 190 ILE n 
1 191 VAL n 
1 192 PHE n 
1 193 HIS n 
1 194 GLY n 
1 195 THR n 
1 196 SER n 
1 197 ASP n 
1 198 TYR n 
1 199 THR n 
1 200 VAL n 
1 201 TYR n 
1 202 PRO n 
1 203 VAL n 
1 204 ASN n 
1 205 GLY n 
1 206 HIS n 
1 207 GLN n 
1 208 VAL n 
1 209 ILE n 
1 210 SER n 
1 211 GLN n 
1 212 TRP n 
1 213 ALA n 
1 214 GLN n 
1 215 THR n 
1 216 ASN n 
1 217 ASP n 
1 218 ARG n 
1 219 ALA n 
1 220 GLY n 
1 221 ASP n 
1 222 GLY n 
1 223 VAL n 
1 224 ASP n 
1 225 ASN n 
1 226 ASN n 
1 227 HIS n 
1 228 ILE n 
1 229 ASP n 
1 230 ASP n 
1 231 GLN n 
1 232 ALA n 
1 233 ASP n 
1 234 VAL n 
1 235 THR n 
1 236 MET n 
1 237 ASN n 
1 238 GLY n 
1 239 SER n 
1 240 VAL n 
1 241 PRO n 
1 242 ASN n 
1 243 GLY n 
1 244 ARG n 
1 245 THR n 
1 246 TYR n 
1 247 THR n 
1 248 ARG n 
1 249 TYR n 
1 250 LEU n 
1 251 TYR n 
1 252 LYS n 
1 253 ASP n 
1 254 GLN n 
1 255 ASN n 
1 256 GLY n 
1 257 ASN n 
1 258 VAL n 
1 259 VAL n 
1 260 MET n 
1 261 GLU n 
1 262 LYS n 
1 263 ILE n 
1 264 MET n 
1 265 VAL n 
1 266 ASN n 
1 267 GLY n 
1 268 MET n 
1 269 GLY n 
1 270 HIS n 
1 271 ALA n 
1 272 TRP n 
1 273 SER n 
1 274 GLY n 
1 275 GLY n 
1 276 SER n 
1 277 THR n 
1 278 ALA n 
1 279 GLY n 
1 280 THR n 
1 281 TYR n 
1 282 THR n 
1 283 ASP n 
1 284 PRO n 
1 285 ALA n 
1 286 GLY n 
1 287 PRO n 
1 288 GLU n 
1 289 ALA n 
1 290 SER n 
1 291 SER n 
1 292 MET n 
1 293 MET n 
1 294 TRP n 
1 295 SER n 
1 296 PHE n 
1 297 PHE n 
1 298 VAL n 
1 299 ASN n 
1 300 HIS n 
1 301 PRO n 
1 302 LYS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   302 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 SAMN05444955_11823 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Lihuaxuella thermophila' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     1173111 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                  ?             'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                 ?             'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                               ?             'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                          ?             'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE                                 ?             'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE                                ?             'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                          ?             'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                  ?             'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                                ?             'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                    ?             'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                               ?             'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                  ?             'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                   ?             'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                               ?             'C5 H11 N O2 S'  149.211 
MG  non-polymer         . 'MAGNESIUM ION'                          ?             'Mg 2'           24.305  
PHE 'L-peptide linking' y PHENYLALANINE                            ?             'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                                  ?             'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                   ?             'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                                ?             'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                               ?             'C11 H12 N2 O2'  204.225 
TRS non-polymer         . 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL 'TRIS BUFFER' 'C4 H12 N O3 1'  122.143 
TYR 'L-peptide linking' y TYROSINE                                 ?             'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                                   ?             'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   1   1   GLY GLY A . n 
A 1 2   PRO 2   2   2   PRO PRO A . n 
A 1 3   ALA 3   3   3   ALA ALA A . n 
A 1 4   GLY 4   4   4   GLY GLY A . n 
A 1 5   GLN 5   5   5   GLN GLN A . n 
A 1 6   PHE 6   6   6   PHE PHE A . n 
A 1 7   ILE 7   7   7   ILE ILE A . n 
A 1 8   ARG 8   8   8   ARG ARG A . n 
A 1 9   ASP 9   9   9   ASP ASP A . n 
A 1 10  THR 10  10  10  THR THR A . n 
A 1 11  ALA 11  11  11  ALA ALA A . n 
A 1 12  PRO 12  12  12  PRO PRO A . n 
A 1 13  ASP 13  13  13  ASP ASP A . n 
A 1 14  GLY 14  14  14  GLY GLY A . n 
A 1 15  ARG 15  15  15  ARG ARG A . n 
A 1 16  VAL 16  16  16  VAL VAL A . n 
A 1 17  TYR 17  17  17  TYR TYR A . n 
A 1 18  LYS 18  18  18  LYS LYS A . n 
A 1 19  LEU 19  19  19  LEU LEU A . n 
A 1 20  TYR 20  20  20  TYR TYR A . n 
A 1 21  ILE 21  21  21  ILE ILE A . n 
A 1 22  PRO 22  22  22  PRO PRO A . n 
A 1 23  SER 23  23  23  SER SER A . n 
A 1 24  GLY 24  24  24  GLY GLY A . n 
A 1 25  TYR 25  25  25  TYR TYR A . n 
A 1 26  ASN 26  26  26  ASN ASN A . n 
A 1 27  GLY 27  27  27  GLY GLY A . n 
A 1 28  SER 28  28  28  SER SER A . n 
A 1 29  THR 29  29  29  THR THR A . n 
A 1 30  PRO 30  30  30  PRO PRO A . n 
A 1 31  LEU 31  31  31  LEU LEU A . n 
A 1 32  PRO 32  32  32  PRO PRO A . n 
A 1 33  LEU 33  33  33  LEU LEU A . n 
A 1 34  VAL 34  34  34  VAL VAL A . n 
A 1 35  VAL 35  35  35  VAL VAL A . n 
A 1 36  MET 36  36  36  MET MET A . n 
A 1 37  LEU 37  37  37  LEU LEU A . n 
A 1 38  HIS 38  38  38  HIS HIS A . n 
A 1 39  GLY 39  39  39  GLY GLY A . n 
A 1 40  CYS 40  40  40  CYS CYS A . n 
A 1 41  THR 41  41  41  THR THR A . n 
A 1 42  GLN 42  42  42  GLN GLN A . n 
A 1 43  ASN 43  43  43  ASN ASN A . n 
A 1 44  PRO 44  44  44  PRO PRO A . n 
A 1 45  ASP 45  45  45  ASP ASP A . n 
A 1 46  ASP 46  46  46  ASP ASP A . n 
A 1 47  PHE 47  47  47  PHE PHE A . n 
A 1 48  ALA 48  48  48  ALA ALA A . n 
A 1 49  ALA 49  49  49  ALA ALA A . n 
A 1 50  GLY 50  50  50  GLY GLY A . n 
A 1 51  THR 51  51  51  THR THR A . n 
A 1 52  GLU 52  52  52  GLU GLU A . n 
A 1 53  MET 53  53  53  MET MET A . n 
A 1 54  ASN 54  54  54  ASN ASN A . n 
A 1 55  VAL 55  55  55  VAL VAL A . n 
A 1 56  TYR 56  56  56  TYR TYR A . n 
A 1 57  ALA 57  57  57  ALA ALA A . n 
A 1 58  GLU 58  58  58  GLU GLU A . n 
A 1 59  GLN 59  59  59  GLN GLN A . n 
A 1 60  ASN 60  60  60  ASN ASN A . n 
A 1 61  ASN 61  61  61  ASN ASN A . n 
A 1 62  PHE 62  62  62  PHE PHE A . n 
A 1 63  LEU 63  63  63  LEU LEU A . n 
A 1 64  VAL 64  64  64  VAL VAL A . n 
A 1 65  ALA 65  65  65  ALA ALA A . n 
A 1 66  TYR 66  66  66  TYR TYR A . n 
A 1 67  PRO 67  67  67  PRO PRO A . n 
A 1 68  GLU 68  68  68  GLU GLU A . n 
A 1 69  GLN 69  69  69  GLN GLN A . n 
A 1 70  PRO 70  70  70  PRO PRO A . n 
A 1 71  SER 71  71  71  SER SER A . n 
A 1 72  SER 72  72  72  SER SER A . n 
A 1 73  ALA 73  73  73  ALA ALA A . n 
A 1 74  ASN 74  74  74  ASN ASN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  ASN 76  76  76  ASN ASN A . n 
A 1 77  LYS 77  77  77  LYS LYS A . n 
A 1 78  CYS 78  78  78  CYS CYS A . n 
A 1 79  TRP 79  79  79  TRP TRP A . n 
A 1 80  ASN 80  80  80  ASN ASN A . n 
A 1 81  TRP 81  81  81  TRP TRP A . n 
A 1 82  PHE 82  82  82  PHE PHE A . n 
A 1 83  ASP 83  83  83  ASP ASP A . n 
A 1 84  SER 84  84  84  SER SER A . n 
A 1 85  ASN 85  85  85  ASN ASN A . n 
A 1 86  HIS 86  86  86  HIS HIS A . n 
A 1 87  GLN 87  87  87  GLN GLN A . n 
A 1 88  SER 88  88  88  SER SER A . n 
A 1 89  ARG 89  89  89  ARG ARG A . n 
A 1 90  GLY 90  90  90  GLY GLY A . n 
A 1 91  ARG 91  91  91  ARG ARG A . n 
A 1 92  GLY 92  92  92  GLY GLY A . n 
A 1 93  GLU 93  93  93  GLU GLU A . n 
A 1 94  PRO 94  94  94  PRO PRO A . n 
A 1 95  ALA 95  95  95  ALA ALA A . n 
A 1 96  SER 96  96  96  SER SER A . n 
A 1 97  ILE 97  97  97  ILE ILE A . n 
A 1 98  ALA 98  98  98  ALA ALA A . n 
A 1 99  GLY 99  99  99  GLY GLY A . n 
A 1 100 VAL 100 100 100 VAL VAL A . n 
A 1 101 VAL 101 101 101 VAL VAL A . n 
A 1 102 GLU 102 102 102 GLU GLU A . n 
A 1 103 ASP 103 103 103 ASP ASP A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 LYS 105 105 105 LYS LYS A . n 
A 1 106 ARG 106 106 106 ARG ARG A . n 
A 1 107 ASN 107 107 107 ASN ASN A . n 
A 1 108 TYR 108 108 108 TYR TYR A . n 
A 1 109 SER 109 109 109 SER SER A . n 
A 1 110 VAL 110 110 110 VAL VAL A . n 
A 1 111 ASP 111 111 111 ASP ASP A . n 
A 1 112 SER 112 112 112 SER SER A . n 
A 1 113 ARG 113 113 113 ARG ARG A . n 
A 1 114 ARG 114 114 114 ARG ARG A . n 
A 1 115 VAL 115 115 115 VAL VAL A . n 
A 1 116 TYR 116 116 116 TYR TYR A . n 
A 1 117 ALA 117 117 117 ALA ALA A . n 
A 1 118 ALA 118 118 118 ALA ALA A . n 
A 1 119 GLY 119 119 119 GLY GLY A . n 
A 1 120 LEU 120 120 120 LEU LEU A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 ALA 122 122 122 ALA ALA A . n 
A 1 123 GLY 123 123 123 GLY GLY A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 ALA 125 125 125 ALA ALA A . n 
A 1 126 MET 126 126 126 MET MET A . n 
A 1 127 SER 127 127 127 SER SER A . n 
A 1 128 VAL 128 128 128 VAL VAL A . n 
A 1 129 ILE 129 129 129 ILE ILE A . n 
A 1 130 MET 130 130 130 MET MET A . n 
A 1 131 GLY 131 131 131 GLY GLY A . n 
A 1 132 ALA 132 132 132 ALA ALA A . n 
A 1 133 THR 133 133 133 THR THR A . n 
A 1 134 TYR 134 134 134 TYR TYR A . n 
A 1 135 PRO 135 135 135 PRO PRO A . n 
A 1 136 ASP 136 136 136 ASP ASP A . n 
A 1 137 VAL 137 137 137 VAL VAL A . n 
A 1 138 PHE 138 138 138 PHE PHE A . n 
A 1 139 ALA 139 139 139 ALA ALA A . n 
A 1 140 ALA 140 140 140 ALA ALA A . n 
A 1 141 ILE 141 141 141 ILE ILE A . n 
A 1 142 GLY 142 142 142 GLY GLY A . n 
A 1 143 VAL 143 143 143 VAL VAL A . n 
A 1 144 GLY 144 144 144 GLY GLY A . n 
A 1 145 SER 145 145 145 SER SER A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 LEU 147 147 147 LEU LEU A . n 
A 1 148 GLU 148 148 148 GLU GLU A . n 
A 1 149 TYR 149 149 149 TYR TYR A . n 
A 1 150 LYS 150 150 150 LYS LYS A . n 
A 1 151 ALA 151 151 151 ALA ALA A . n 
A 1 152 ALA 152 152 152 ALA ALA A . n 
A 1 153 THR 153 153 153 THR THR A . n 
A 1 154 SER 154 154 154 SER SER A . n 
A 1 155 MET 155 155 155 MET MET A . n 
A 1 156 THR 156 156 156 THR THR A . n 
A 1 157 SER 157 157 157 SER SER A . n 
A 1 158 ALA 158 158 158 ALA ALA A . n 
A 1 159 TYR 159 159 159 TYR TYR A . n 
A 1 160 MET 160 160 160 MET MET A . n 
A 1 161 ALA 161 161 161 ALA ALA A . n 
A 1 162 MET 162 162 162 MET MET A . n 
A 1 163 ILE 163 163 163 ILE ILE A . n 
A 1 164 ASN 164 164 164 ASN ASN A . n 
A 1 165 GLY 165 165 165 GLY GLY A . n 
A 1 166 GLY 166 166 166 GLY GLY A . n 
A 1 167 PRO 167 167 167 PRO PRO A . n 
A 1 168 ASP 168 168 168 ASP ASP A . n 
A 1 169 PRO 169 169 169 PRO PRO A . n 
A 1 170 VAL 170 170 170 VAL VAL A . n 
A 1 171 GLN 171 171 171 GLN GLN A . n 
A 1 172 GLN 172 172 172 GLN GLN A . n 
A 1 173 GLY 173 173 173 GLY GLY A . n 
A 1 174 ASN 174 174 174 ASN ASN A . n 
A 1 175 LEU 175 175 175 LEU LEU A . n 
A 1 176 ALA 176 176 176 ALA ALA A . n 
A 1 177 TYR 177 177 177 TYR TYR A . n 
A 1 178 GLN 178 178 178 GLN GLN A . n 
A 1 179 ALA 179 179 179 ALA ALA A . n 
A 1 180 MET 180 180 180 MET MET A . n 
A 1 181 GLY 181 181 181 GLY GLY A . n 
A 1 182 SER 182 182 182 SER SER A . n 
A 1 183 HIS 183 183 183 HIS HIS A . n 
A 1 184 ALA 184 184 184 ALA ALA A . n 
A 1 185 ARG 185 185 185 ARG ARG A . n 
A 1 186 VAL 186 186 186 VAL VAL A . n 
A 1 187 VAL 187 187 187 VAL VAL A . n 
A 1 188 PRO 188 188 188 PRO PRO A . n 
A 1 189 VAL 189 189 189 VAL VAL A . n 
A 1 190 ILE 190 190 190 ILE ILE A . n 
A 1 191 VAL 191 191 191 VAL VAL A . n 
A 1 192 PHE 192 192 192 PHE PHE A . n 
A 1 193 HIS 193 193 193 HIS HIS A . n 
A 1 194 GLY 194 194 194 GLY GLY A . n 
A 1 195 THR 195 195 195 THR THR A . n 
A 1 196 SER 196 196 196 SER SER A . n 
A 1 197 ASP 197 197 197 ASP ASP A . n 
A 1 198 TYR 198 198 198 TYR TYR A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 VAL 200 200 200 VAL VAL A . n 
A 1 201 TYR 201 201 201 TYR TYR A . n 
A 1 202 PRO 202 202 202 PRO PRO A . n 
A 1 203 VAL 203 203 203 VAL VAL A . n 
A 1 204 ASN 204 204 204 ASN ASN A . n 
A 1 205 GLY 205 205 205 GLY GLY A . n 
A 1 206 HIS 206 206 206 HIS HIS A . n 
A 1 207 GLN 207 207 207 GLN GLN A . n 
A 1 208 VAL 208 208 208 VAL VAL A . n 
A 1 209 ILE 209 209 209 ILE ILE A . n 
A 1 210 SER 210 210 210 SER SER A . n 
A 1 211 GLN 211 211 211 GLN GLN A . n 
A 1 212 TRP 212 212 212 TRP TRP A . n 
A 1 213 ALA 213 213 213 ALA ALA A . n 
A 1 214 GLN 214 214 214 GLN GLN A . n 
A 1 215 THR 215 215 215 THR THR A . n 
A 1 216 ASN 216 216 216 ASN ASN A . n 
A 1 217 ASP 217 217 217 ASP ASP A . n 
A 1 218 ARG 218 218 218 ARG ARG A . n 
A 1 219 ALA 219 219 219 ALA ALA A . n 
A 1 220 GLY 220 220 220 GLY GLY A . n 
A 1 221 ASP 221 221 221 ASP ASP A . n 
A 1 222 GLY 222 222 222 GLY GLY A . n 
A 1 223 VAL 223 223 ?   ?   ?   A . n 
A 1 224 ASP 224 224 ?   ?   ?   A . n 
A 1 225 ASN 225 225 225 ASN ASN A . n 
A 1 226 ASN 226 226 226 ASN ASN A . n 
A 1 227 HIS 227 227 227 HIS HIS A . n 
A 1 228 ILE 228 228 228 ILE ILE A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 ASP 230 230 230 ASP ASP A . n 
A 1 231 GLN 231 231 231 GLN GLN A . n 
A 1 232 ALA 232 232 232 ALA ALA A . n 
A 1 233 ASP 233 233 233 ASP ASP A . n 
A 1 234 VAL 234 234 234 VAL VAL A . n 
A 1 235 THR 235 235 235 THR THR A . n 
A 1 236 MET 236 236 236 MET MET A . n 
A 1 237 ASN 237 237 237 ASN ASN A . n 
A 1 238 GLY 238 238 238 GLY GLY A . n 
A 1 239 SER 239 239 239 SER SER A . n 
A 1 240 VAL 240 240 240 VAL VAL A . n 
A 1 241 PRO 241 241 241 PRO PRO A . n 
A 1 242 ASN 242 242 242 ASN ASN A . n 
A 1 243 GLY 243 243 243 GLY GLY A . n 
A 1 244 ARG 244 244 244 ARG ARG A . n 
A 1 245 THR 245 245 245 THR THR A . n 
A 1 246 TYR 246 246 246 TYR TYR A . n 
A 1 247 THR 247 247 247 THR THR A . n 
A 1 248 ARG 248 248 248 ARG ARG A . n 
A 1 249 TYR 249 249 249 TYR TYR A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 TYR 251 251 251 TYR TYR A . n 
A 1 252 LYS 252 252 252 LYS LYS A . n 
A 1 253 ASP 253 253 253 ASP ASP A . n 
A 1 254 GLN 254 254 254 GLN GLN A . n 
A 1 255 ASN 255 255 255 ASN ASN A . n 
A 1 256 GLY 256 256 256 GLY GLY A . n 
A 1 257 ASN 257 257 257 ASN ASN A . n 
A 1 258 VAL 258 258 258 VAL VAL A . n 
A 1 259 VAL 259 259 259 VAL VAL A . n 
A 1 260 MET 260 260 260 MET MET A . n 
A 1 261 GLU 261 261 261 GLU GLU A . n 
A 1 262 LYS 262 262 262 LYS LYS A . n 
A 1 263 ILE 263 263 263 ILE ILE A . n 
A 1 264 MET 264 264 264 MET MET A . n 
A 1 265 VAL 265 265 265 VAL VAL A . n 
A 1 266 ASN 266 266 266 ASN ASN A . n 
A 1 267 GLY 267 267 267 GLY GLY A . n 
A 1 268 MET 268 268 268 MET MET A . n 
A 1 269 GLY 269 269 269 GLY GLY A . n 
A 1 270 HIS 270 270 270 HIS HIS A . n 
A 1 271 ALA 271 271 271 ALA ALA A . n 
A 1 272 TRP 272 272 272 TRP TRP A . n 
A 1 273 SER 273 273 273 SER SER A . n 
A 1 274 GLY 274 274 274 GLY GLY A . n 
A 1 275 GLY 275 275 275 GLY GLY A . n 
A 1 276 SER 276 276 276 SER SER A . n 
A 1 277 THR 277 277 277 THR THR A . n 
A 1 278 ALA 278 278 278 ALA ALA A . n 
A 1 279 GLY 279 279 279 GLY GLY A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 TYR 281 281 281 TYR TYR A . n 
A 1 282 THR 282 282 282 THR THR A . n 
A 1 283 ASP 283 283 283 ASP ASP A . n 
A 1 284 PRO 284 284 284 PRO PRO A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 GLY 286 286 286 GLY GLY A . n 
A 1 287 PRO 287 287 287 PRO PRO A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 ALA 289 289 289 ALA ALA A . n 
A 1 290 SER 290 290 290 SER SER A . n 
A 1 291 SER 291 291 291 SER SER A . n 
A 1 292 MET 292 292 292 MET MET A . n 
A 1 293 MET 293 293 293 MET MET A . n 
A 1 294 TRP 294 294 294 TRP TRP A . n 
A 1 295 SER 295 295 295 SER SER A . n 
A 1 296 PHE 296 296 296 PHE PHE A . n 
A 1 297 PHE 297 297 297 PHE PHE A . n 
A 1 298 VAL 298 298 298 VAL VAL A . n 
A 1 299 ASN 299 299 299 ASN ASN A . n 
A 1 300 HIS 300 300 300 HIS HIS A . n 
A 1 301 PRO 301 301 301 PRO PRO A . n 
A 1 302 LYS 302 302 302 LYS LYS A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 TRS 1   401 401 TRS TRS A . 
C 3 MG  1   402 1   MG  MG  A . 
D 4 HOH 1   501 143 HOH HOH A . 
D 4 HOH 2   502 205 HOH HOH A . 
D 4 HOH 3   503 242 HOH HOH A . 
D 4 HOH 4   504 247 HOH HOH A . 
D 4 HOH 5   505 216 HOH HOH A . 
D 4 HOH 6   506 48  HOH HOH A . 
D 4 HOH 7   507 271 HOH HOH A . 
D 4 HOH 8   508 165 HOH HOH A . 
D 4 HOH 9   509 140 HOH HOH A . 
D 4 HOH 10  510 263 HOH HOH A . 
D 4 HOH 11  511 91  HOH HOH A . 
D 4 HOH 12  512 219 HOH HOH A . 
D 4 HOH 13  513 40  HOH HOH A . 
D 4 HOH 14  514 104 HOH HOH A . 
D 4 HOH 15  515 199 HOH HOH A . 
D 4 HOH 16  516 130 HOH HOH A . 
D 4 HOH 17  517 168 HOH HOH A . 
D 4 HOH 18  518 115 HOH HOH A . 
D 4 HOH 19  519 138 HOH HOH A . 
D 4 HOH 20  520 167 HOH HOH A . 
D 4 HOH 21  521 101 HOH HOH A . 
D 4 HOH 22  522 198 HOH HOH A . 
D 4 HOH 23  523 201 HOH HOH A . 
D 4 HOH 24  524 169 HOH HOH A . 
D 4 HOH 25  525 277 HOH HOH A . 
D 4 HOH 26  526 285 HOH HOH A . 
D 4 HOH 27  527 225 HOH HOH A . 
D 4 HOH 28  528 237 HOH HOH A . 
D 4 HOH 29  529 256 HOH HOH A . 
D 4 HOH 30  530 156 HOH HOH A . 
D 4 HOH 31  531 291 HOH HOH A . 
D 4 HOH 32  532 163 HOH HOH A . 
D 4 HOH 33  533 166 HOH HOH A . 
D 4 HOH 34  534 15  HOH HOH A . 
D 4 HOH 35  535 8   HOH HOH A . 
D 4 HOH 36  536 238 HOH HOH A . 
D 4 HOH 37  537 82  HOH HOH A . 
D 4 HOH 38  538 66  HOH HOH A . 
D 4 HOH 39  539 299 HOH HOH A . 
D 4 HOH 40  540 102 HOH HOH A . 
D 4 HOH 41  541 26  HOH HOH A . 
D 4 HOH 42  542 30  HOH HOH A . 
D 4 HOH 43  543 267 HOH HOH A . 
D 4 HOH 44  544 39  HOH HOH A . 
D 4 HOH 45  545 181 HOH HOH A . 
D 4 HOH 46  546 21  HOH HOH A . 
D 4 HOH 47  547 250 HOH HOH A . 
D 4 HOH 48  548 141 HOH HOH A . 
D 4 HOH 49  549 132 HOH HOH A . 
D 4 HOH 50  550 10  HOH HOH A . 
D 4 HOH 51  551 103 HOH HOH A . 
D 4 HOH 52  552 88  HOH HOH A . 
D 4 HOH 53  553 233 HOH HOH A . 
D 4 HOH 54  554 129 HOH HOH A . 
D 4 HOH 55  555 38  HOH HOH A . 
D 4 HOH 56  556 84  HOH HOH A . 
D 4 HOH 57  557 209 HOH HOH A . 
D 4 HOH 58  558 193 HOH HOH A . 
D 4 HOH 59  559 36  HOH HOH A . 
D 4 HOH 60  560 93  HOH HOH A . 
D 4 HOH 61  561 2   HOH HOH A . 
D 4 HOH 62  562 125 HOH HOH A . 
D 4 HOH 63  563 22  HOH HOH A . 
D 4 HOH 64  564 56  HOH HOH A . 
D 4 HOH 65  565 194 HOH HOH A . 
D 4 HOH 66  566 269 HOH HOH A . 
D 4 HOH 67  567 255 HOH HOH A . 
D 4 HOH 68  568 217 HOH HOH A . 
D 4 HOH 69  569 3   HOH HOH A . 
D 4 HOH 70  570 92  HOH HOH A . 
D 4 HOH 71  571 5   HOH HOH A . 
D 4 HOH 72  572 20  HOH HOH A . 
D 4 HOH 73  573 215 HOH HOH A . 
D 4 HOH 74  574 274 HOH HOH A . 
D 4 HOH 75  575 213 HOH HOH A . 
D 4 HOH 76  576 131 HOH HOH A . 
D 4 HOH 77  577 77  HOH HOH A . 
D 4 HOH 78  578 64  HOH HOH A . 
D 4 HOH 79  579 46  HOH HOH A . 
D 4 HOH 80  580 106 HOH HOH A . 
D 4 HOH 81  581 12  HOH HOH A . 
D 4 HOH 82  582 119 HOH HOH A . 
D 4 HOH 83  583 43  HOH HOH A . 
D 4 HOH 84  584 19  HOH HOH A . 
D 4 HOH 85  585 53  HOH HOH A . 
D 4 HOH 86  586 44  HOH HOH A . 
D 4 HOH 87  587 109 HOH HOH A . 
D 4 HOH 88  588 178 HOH HOH A . 
D 4 HOH 89  589 34  HOH HOH A . 
D 4 HOH 90  590 79  HOH HOH A . 
D 4 HOH 91  591 148 HOH HOH A . 
D 4 HOH 92  592 155 HOH HOH A . 
D 4 HOH 93  593 121 HOH HOH A . 
D 4 HOH 94  594 134 HOH HOH A . 
D 4 HOH 95  595 4   HOH HOH A . 
D 4 HOH 96  596 117 HOH HOH A . 
D 4 HOH 97  597 65  HOH HOH A . 
D 4 HOH 98  598 200 HOH HOH A . 
D 4 HOH 99  599 17  HOH HOH A . 
D 4 HOH 100 600 6   HOH HOH A . 
D 4 HOH 101 601 37  HOH HOH A . 
D 4 HOH 102 602 49  HOH HOH A . 
D 4 HOH 103 603 7   HOH HOH A . 
D 4 HOH 104 604 108 HOH HOH A . 
D 4 HOH 105 605 162 HOH HOH A . 
D 4 HOH 106 606 176 HOH HOH A . 
D 4 HOH 107 607 35  HOH HOH A . 
D 4 HOH 108 608 9   HOH HOH A . 
D 4 HOH 109 609 96  HOH HOH A . 
D 4 HOH 110 610 249 HOH HOH A . 
D 4 HOH 111 611 147 HOH HOH A . 
D 4 HOH 112 612 276 HOH HOH A . 
D 4 HOH 113 613 87  HOH HOH A . 
D 4 HOH 114 614 51  HOH HOH A . 
D 4 HOH 115 615 54  HOH HOH A . 
D 4 HOH 116 616 248 HOH HOH A . 
D 4 HOH 117 617 100 HOH HOH A . 
D 4 HOH 118 618 137 HOH HOH A . 
D 4 HOH 119 619 114 HOH HOH A . 
D 4 HOH 120 620 71  HOH HOH A . 
D 4 HOH 121 621 152 HOH HOH A . 
D 4 HOH 122 622 62  HOH HOH A . 
D 4 HOH 123 623 55  HOH HOH A . 
D 4 HOH 124 624 24  HOH HOH A . 
D 4 HOH 125 625 73  HOH HOH A . 
D 4 HOH 126 626 33  HOH HOH A . 
D 4 HOH 127 627 172 HOH HOH A . 
D 4 HOH 128 628 47  HOH HOH A . 
D 4 HOH 129 629 112 HOH HOH A . 
D 4 HOH 130 630 107 HOH HOH A . 
D 4 HOH 131 631 139 HOH HOH A . 
D 4 HOH 132 632 52  HOH HOH A . 
D 4 HOH 133 633 232 HOH HOH A . 
D 4 HOH 134 634 86  HOH HOH A . 
D 4 HOH 135 635 1   HOH HOH A . 
D 4 HOH 136 636 18  HOH HOH A . 
D 4 HOH 137 637 59  HOH HOH A . 
D 4 HOH 138 638 95  HOH HOH A . 
D 4 HOH 139 639 185 HOH HOH A . 
D 4 HOH 140 640 32  HOH HOH A . 
D 4 HOH 141 641 76  HOH HOH A . 
D 4 HOH 142 642 210 HOH HOH A . 
D 4 HOH 143 643 29  HOH HOH A . 
D 4 HOH 144 644 89  HOH HOH A . 
D 4 HOH 145 645 83  HOH HOH A . 
D 4 HOH 146 646 224 HOH HOH A . 
D 4 HOH 147 647 258 HOH HOH A . 
D 4 HOH 148 648 14  HOH HOH A . 
D 4 HOH 149 649 27  HOH HOH A . 
D 4 HOH 150 650 42  HOH HOH A . 
D 4 HOH 151 651 75  HOH HOH A . 
D 4 HOH 152 652 230 HOH HOH A . 
D 4 HOH 153 653 262 HOH HOH A . 
D 4 HOH 154 654 60  HOH HOH A . 
D 4 HOH 155 655 240 HOH HOH A . 
D 4 HOH 156 656 105 HOH HOH A . 
D 4 HOH 157 657 158 HOH HOH A . 
D 4 HOH 158 658 192 HOH HOH A . 
D 4 HOH 159 659 13  HOH HOH A . 
D 4 HOH 160 660 245 HOH HOH A . 
D 4 HOH 161 661 161 HOH HOH A . 
D 4 HOH 162 662 31  HOH HOH A . 
D 4 HOH 163 663 284 HOH HOH A . 
D 4 HOH 164 664 81  HOH HOH A . 
D 4 HOH 165 665 184 HOH HOH A . 
D 4 HOH 166 666 74  HOH HOH A . 
D 4 HOH 167 667 281 HOH HOH A . 
D 4 HOH 168 668 135 HOH HOH A . 
D 4 HOH 169 669 164 HOH HOH A . 
D 4 HOH 170 670 61  HOH HOH A . 
D 4 HOH 171 671 241 HOH HOH A . 
D 4 HOH 172 672 202 HOH HOH A . 
D 4 HOH 173 673 261 HOH HOH A . 
D 4 HOH 174 674 63  HOH HOH A . 
D 4 HOH 175 675 68  HOH HOH A . 
D 4 HOH 176 676 50  HOH HOH A . 
D 4 HOH 177 677 23  HOH HOH A . 
D 4 HOH 178 678 11  HOH HOH A . 
D 4 HOH 179 679 228 HOH HOH A . 
D 4 HOH 180 680 186 HOH HOH A . 
D 4 HOH 181 681 99  HOH HOH A . 
D 4 HOH 182 682 72  HOH HOH A . 
D 4 HOH 183 683 300 HOH HOH A . 
D 4 HOH 184 684 180 HOH HOH A . 
D 4 HOH 185 685 45  HOH HOH A . 
D 4 HOH 186 686 70  HOH HOH A . 
D 4 HOH 187 687 223 HOH HOH A . 
D 4 HOH 188 688 273 HOH HOH A . 
D 4 HOH 189 689 67  HOH HOH A . 
D 4 HOH 190 690 25  HOH HOH A . 
D 4 HOH 191 691 94  HOH HOH A . 
D 4 HOH 192 692 218 HOH HOH A . 
D 4 HOH 193 693 111 HOH HOH A . 
D 4 HOH 194 694 295 HOH HOH A . 
D 4 HOH 195 695 197 HOH HOH A . 
D 4 HOH 196 696 58  HOH HOH A . 
D 4 HOH 197 697 57  HOH HOH A . 
D 4 HOH 198 698 90  HOH HOH A . 
D 4 HOH 199 699 177 HOH HOH A . 
D 4 HOH 200 700 253 HOH HOH A . 
D 4 HOH 201 701 16  HOH HOH A . 
D 4 HOH 202 702 211 HOH HOH A . 
D 4 HOH 203 703 153 HOH HOH A . 
D 4 HOH 204 704 28  HOH HOH A . 
D 4 HOH 205 705 142 HOH HOH A . 
D 4 HOH 206 706 118 HOH HOH A . 
D 4 HOH 207 707 145 HOH HOH A . 
D 4 HOH 208 708 298 HOH HOH A . 
D 4 HOH 209 709 195 HOH HOH A . 
D 4 HOH 210 710 252 HOH HOH A . 
D 4 HOH 211 711 157 HOH HOH A . 
D 4 HOH 212 712 183 HOH HOH A . 
D 4 HOH 213 713 275 HOH HOH A . 
D 4 HOH 214 714 187 HOH HOH A . 
D 4 HOH 215 715 294 HOH HOH A . 
D 4 HOH 216 716 98  HOH HOH A . 
D 4 HOH 217 717 207 HOH HOH A . 
D 4 HOH 218 718 182 HOH HOH A . 
D 4 HOH 219 719 151 HOH HOH A . 
D 4 HOH 220 720 122 HOH HOH A . 
D 4 HOH 221 721 113 HOH HOH A . 
D 4 HOH 222 722 136 HOH HOH A . 
D 4 HOH 223 723 290 HOH HOH A . 
D 4 HOH 224 724 272 HOH HOH A . 
D 4 HOH 225 725 133 HOH HOH A . 
D 4 HOH 226 726 159 HOH HOH A . 
D 4 HOH 227 727 286 HOH HOH A . 
D 4 HOH 228 728 149 HOH HOH A . 
D 4 HOH 229 729 144 HOH HOH A . 
D 4 HOH 230 730 254 HOH HOH A . 
D 4 HOH 231 731 171 HOH HOH A . 
D 4 HOH 232 732 80  HOH HOH A . 
D 4 HOH 233 733 146 HOH HOH A . 
D 4 HOH 234 734 170 HOH HOH A . 
D 4 HOH 235 735 246 HOH HOH A . 
D 4 HOH 236 736 257 HOH HOH A . 
D 4 HOH 237 737 244 HOH HOH A . 
D 4 HOH 238 738 287 HOH HOH A . 
D 4 HOH 239 739 126 HOH HOH A . 
D 4 HOH 240 740 150 HOH HOH A . 
D 4 HOH 241 741 189 HOH HOH A . 
D 4 HOH 242 742 174 HOH HOH A . 
D 4 HOH 243 743 173 HOH HOH A . 
D 4 HOH 244 744 239 HOH HOH A . 
D 4 HOH 245 745 97  HOH HOH A . 
D 4 HOH 246 746 268 HOH HOH A . 
D 4 HOH 247 747 124 HOH HOH A . 
D 4 HOH 248 748 296 HOH HOH A . 
D 4 HOH 249 749 127 HOH HOH A . 
D 4 HOH 250 750 116 HOH HOH A . 
D 4 HOH 251 751 266 HOH HOH A . 
D 4 HOH 252 752 110 HOH HOH A . 
D 4 HOH 253 753 297 HOH HOH A . 
D 4 HOH 254 754 78  HOH HOH A . 
D 4 HOH 255 755 190 HOH HOH A . 
D 4 HOH 256 756 188 HOH HOH A . 
D 4 HOH 257 757 128 HOH HOH A . 
D 4 HOH 258 758 175 HOH HOH A . 
D 4 HOH 259 759 288 HOH HOH A . 
D 4 HOH 260 760 41  HOH HOH A . 
D 4 HOH 261 761 69  HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.20.1_4487 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XSCALE ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BYU 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     88.585 
_cell.length_a_esd                 ? 
_cell.length_b                     88.585 
_cell.length_b_esd                 ? 
_cell.length_c                     49.817 
_cell.length_c_esd                 ? 
_cell.volume                       338553.559 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BYU 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                172 
_symmetry.space_group_name_Hall            'P 64' 
_symmetry.space_group_name_H-M             'P 64' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BYU 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             ? 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          29.28 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '120 mM MgCl2, 60 mM Tris, 14% PEG 4K' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            298.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 2M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-10-18 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    'Si filter' 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ALS BEAMLINE 5.0.1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   5.0.1 
_diffrn_source.pdbx_synchrotron_site       ALS 
# 
_reflns.B_iso_Wilson_estimate                          16.75 
_reflns.entry_id                                       9BYU 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.75 
_reflns.d_resolution_low                               76.72 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     20114 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           89.02 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                7.2 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          18.03 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   1 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.75 
_reflns_shell.d_res_low                                     1.81 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             819 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.964 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.1528 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               18.60 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9BYU 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.75 
_refine.ls_d_res_low                             76.72 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     20110 
_refine.ls_number_reflns_R_free                  1985 
_refine.ls_number_reflns_R_work                  18125 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    89.02 
_refine.ls_percent_reflns_R_free                 9.87 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1458 
_refine.ls_R_factor_R_free                       0.1932 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1405 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.45 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 18.8669 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1927 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.75 
_refine_hist.d_res_low                        76.72 
_refine_hist.number_atoms_solvent             261 
_refine_hist.number_atoms_total               2533 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2263 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         9 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0083 ? 2428 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.8682 ? 3326 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0584 ? 342  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0082 ? 453  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 6.2630 ? 359  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.75 1.79  . . 50  460  32.26  . . . . 0.2850 . . . . . . . . . . . 0.3537 
'X-RAY DIFFRACTION' 1.79 1.84  . . 87  781  53.61  . . . . 0.2251 . . . . . . . . . . . 0.3273 
'X-RAY DIFFRACTION' 1.84 1.90  . . 120 1082 75.55  . . . . 0.1929 . . . . . . . . . . . 0.2666 
'X-RAY DIFFRACTION' 1.90 1.96  . . 130 1269 86.84  . . . . 0.1580 . . . . . . . . . . . 0.2641 
'X-RAY DIFFRACTION' 1.96 2.03  . . 153 1376 96.59  . . . . 0.1566 . . . . . . . . . . . 0.2191 
'X-RAY DIFFRACTION' 2.03 2.11  . . 159 1458 99.75  . . . . 0.1503 . . . . . . . . . . . 0.2318 
'X-RAY DIFFRACTION' 2.11 2.21  . . 165 1438 100.00 . . . . 0.1396 . . . . . . . . . . . 0.1929 
'X-RAY DIFFRACTION' 2.21 2.32  . . 152 1463 100.00 . . . . 0.1417 . . . . . . . . . . . 0.2073 
'X-RAY DIFFRACTION' 2.32 2.47  . . 156 1461 100.00 . . . . 0.1392 . . . . . . . . . . . 0.1853 
'X-RAY DIFFRACTION' 2.47 2.66  . . 164 1436 100.00 . . . . 0.1452 . . . . . . . . . . . 0.1966 
'X-RAY DIFFRACTION' 2.66 2.93  . . 162 1463 100.00 . . . . 0.1463 . . . . . . . . . . . 0.1937 
'X-RAY DIFFRACTION' 2.93 3.35  . . 161 1465 100.00 . . . . 0.1345 . . . . . . . . . . . 0.1908 
'X-RAY DIFFRACTION' 3.35 4.22  . . 164 1461 100.00 . . . . 0.1156 . . . . . . . . . . . 0.1518 
'X-RAY DIFFRACTION' 4.22 76.72 . . 162 1512 100.00 . . . . 0.1289 . . . . . . . . . . . 0.1656 
# 
_struct.entry_id                     9BYU 
_struct.title                        'Structure and stability of an apo thermophilic esterase that hydrolyzes polyhydroxybutyrate' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BYU 
_struct_keywords.text            
;bioplastic, enzymology, polyhydroxyalkanoates, polymer hydrolysis, thermophile, Polyhydroxybutyrate Depolymerase, BIOSYNTHETIC PROTEIN
;
_struct_keywords.pdbx_keywords   'BIOSYNTHETIC PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A0A1H8IKU3_9BACL 
_struct_ref.pdbx_db_accession          A0A1H8IKU3 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;AGQFIRDTAPDGRVYKLYIPSGYNGSTPLPLVVMLHGCTQNPDDFAAGTEMNVYAEQNNFLVAYPEQPSSANLNKCWNWF
DSNHQSRGRGEPASIAGVVEDVKRNYSVDSRRVYAAGLSAGGAMSVIMGATYPDVFAAIGVGSGLEYKAATSMTSAYMAM
INGGPDPVQQGNLAYQAMGSHARVVPVIVFHGTSDYTVYPVNGHQVISQWAQTNDRAGDGVDNNHIDDQADVTMNGSVPN
GRTYTRYLYKDQNGNVVMEKIMVNGMGHAWSGGSTAGTYTDPAGPEASSMMWSFFVNHPK
;
_struct_ref.pdbx_align_begin           34 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9BYU 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 3 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 302 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             A0A1H8IKU3 
_struct_ref_seq.db_align_beg                  34 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  333 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       3 
_struct_ref_seq.pdbx_auth_seq_align_end       302 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9BYU GLY A 1 ? UNP A0A1H8IKU3 ? ? 'expression tag' 1 1 
1 9BYU PRO A 2 ? UNP A0A1H8IKU3 ? ? 'expression tag' 2 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 43  ? GLU A 52  ? ASN A 43  GLU A 52  1 ? 10 
HELX_P HELX_P2  AA2 GLU A 52  ? ASN A 61  ? GLU A 52  ASN A 61  1 ? 10 
HELX_P HELX_P3  AA3 ASP A 83  ? GLN A 87  ? ASP A 83  GLN A 87  5 ? 5  
HELX_P HELX_P4  AA4 ARG A 91  ? TYR A 108 ? ARG A 91  TYR A 108 1 ? 18 
HELX_P HELX_P5  AA5 SER A 121 ? TYR A 134 ? SER A 121 TYR A 134 1 ? 14 
HELX_P HELX_P6  AA6 SER A 154 ? THR A 156 ? SER A 154 THR A 156 5 ? 3  
HELX_P HELX_P7  AA7 SER A 157 ? GLY A 165 ? SER A 157 GLY A 165 1 ? 9  
HELX_P HELX_P8  AA8 ASP A 168 ? MET A 180 ? ASP A 168 MET A 180 1 ? 13 
HELX_P HELX_P9  AA9 GLY A 181 ? ALA A 184 ? GLY A 181 ALA A 184 5 ? 4  
HELX_P HELX_P10 AB1 PRO A 202 ? GLY A 220 ? PRO A 202 GLY A 220 1 ? 19 
HELX_P HELX_P11 AB2 GLU A 288 ? ASN A 299 ? GLU A 288 ASN A 299 1 ? 12 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 40  SG  ? ? ? 1_555 A CYS 78 SG ? ? A CYS 40  A CYS 78  1_555 ? ? ? ? ? ? ? 2.041 ? ? 
metalc1 metalc ? ? A ASP 229 OD1 ? ? ? 1_555 C MG  .  MG ? ? A ASP 229 A MG  402 1_555 ? ? ? ? ? ? ? 2.591 ? ? 
metalc2 metalc ? ? A GLN 231 O   ? ? ? 1_555 C MG  .  MG ? ? A GLN 231 A MG  402 1_555 ? ? ? ? ? ? ? 2.761 ? ? 
metalc3 metalc ? ? A ASP 233 OD1 ? ? ? 1_555 C MG  .  MG ? ? A ASP 233 A MG  402 1_555 ? ? ? ? ? ? ? 2.710 ? ? 
metalc4 metalc ? ? A ASP 233 OD2 ? ? ? 1_555 C MG  .  MG ? ? A ASP 233 A MG  402 1_555 ? ? ? ? ? ? ? 2.415 ? ? 
metalc5 metalc ? ? C MG  .   MG  ? ? ? 1_555 D HOH .  O  ? ? A MG  402 A HOH 557 1_555 ? ? ? ? ? ? ? 2.310 ? ? 
metalc6 metalc ? ? C MG  .   MG  ? ? ? 1_555 D HOH .  O  ? ? A MG  402 A HOH 575 1_555 ? ? ? ? ? ? ? 2.912 ? ? 
metalc7 metalc ? ? C MG  .   MG  ? ? ? 1_555 D HOH .  O  ? ? A MG  402 A HOH 589 1_555 ? ? ? ? ? ? ? 2.210 ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
metalc ? ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OD1 ? A ASP 229 ? A ASP 229 ? 1_555 MG ? C MG . ? A MG 402 ? 1_555 O   ? A GLN 231 ? A GLN 231 ? 1_555 78.2  ? 
2  OD1 ? A ASP 229 ? A ASP 229 ? 1_555 MG ? C MG . ? A MG 402 ? 1_555 OD1 ? A ASP 233 ? A ASP 233 ? 1_555 146.0 ? 
3  O   ? A GLN 231 ? A GLN 231 ? 1_555 MG ? C MG . ? A MG 402 ? 1_555 OD1 ? A ASP 233 ? A ASP 233 ? 1_555 91.3  ? 
4  OD1 ? A ASP 229 ? A ASP 229 ? 1_555 MG ? C MG . ? A MG 402 ? 1_555 OD2 ? A ASP 233 ? A ASP 233 ? 1_555 154.8 ? 
5  O   ? A GLN 231 ? A GLN 231 ? 1_555 MG ? C MG . ? A MG 402 ? 1_555 OD2 ? A ASP 233 ? A ASP 233 ? 1_555 83.3  ? 
6  OD1 ? A ASP 233 ? A ASP 233 ? 1_555 MG ? C MG . ? A MG 402 ? 1_555 OD2 ? A ASP 233 ? A ASP 233 ? 1_555 50.4  ? 
7  OD1 ? A ASP 229 ? A ASP 229 ? 1_555 MG ? C MG . ? A MG 402 ? 1_555 O   ? D HOH .   ? A HOH 557 ? 1_555 78.9  ? 
8  O   ? A GLN 231 ? A GLN 231 ? 1_555 MG ? C MG . ? A MG 402 ? 1_555 O   ? D HOH .   ? A HOH 557 ? 1_555 147.7 ? 
9  OD1 ? A ASP 233 ? A ASP 233 ? 1_555 MG ? C MG . ? A MG 402 ? 1_555 O   ? D HOH .   ? A HOH 557 ? 1_555 120.2 ? 
10 OD2 ? A ASP 233 ? A ASP 233 ? 1_555 MG ? C MG . ? A MG 402 ? 1_555 O   ? D HOH .   ? A HOH 557 ? 1_555 109.9 ? 
11 OD1 ? A ASP 229 ? A ASP 229 ? 1_555 MG ? C MG . ? A MG 402 ? 1_555 O   ? D HOH .   ? A HOH 575 ? 1_555 131.1 ? 
12 O   ? A GLN 231 ? A GLN 231 ? 1_555 MG ? C MG . ? A MG 402 ? 1_555 O   ? D HOH .   ? A HOH 575 ? 1_555 147.8 ? 
13 OD1 ? A ASP 233 ? A ASP 233 ? 1_555 MG ? C MG . ? A MG 402 ? 1_555 O   ? D HOH .   ? A HOH 575 ? 1_555 57.2  ? 
14 OD2 ? A ASP 233 ? A ASP 233 ? 1_555 MG ? C MG . ? A MG 402 ? 1_555 O   ? D HOH .   ? A HOH 575 ? 1_555 71.9  ? 
15 O   ? D HOH .   ? A HOH 557 ? 1_555 MG ? C MG . ? A MG 402 ? 1_555 O   ? D HOH .   ? A HOH 575 ? 1_555 63.0  ? 
16 OD1 ? A ASP 229 ? A ASP 229 ? 1_555 MG ? C MG . ? A MG 402 ? 1_555 O   ? D HOH .   ? A HOH 589 ? 1_555 79.0  ? 
17 O   ? A GLN 231 ? A GLN 231 ? 1_555 MG ? C MG . ? A MG 402 ? 1_555 O   ? D HOH .   ? A HOH 589 ? 1_555 71.9  ? 
18 OD1 ? A ASP 233 ? A ASP 233 ? 1_555 MG ? C MG . ? A MG 402 ? 1_555 O   ? D HOH .   ? A HOH 589 ? 1_555 128.6 ? 
19 OD2 ? A ASP 233 ? A ASP 233 ? 1_555 MG ? C MG . ? A MG 402 ? 1_555 O   ? D HOH .   ? A HOH 589 ? 1_555 79.0  ? 
20 O   ? D HOH .   ? A HOH 557 ? 1_555 MG ? C MG . ? A MG 402 ? 1_555 O   ? D HOH .   ? A HOH 589 ? 1_555 81.6  ? 
21 O   ? D HOH .   ? A HOH 575 ? 1_555 MG ? C MG . ? A MG 402 ? 1_555 O   ? D HOH .   ? A HOH 589 ? 1_555 120.9 ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      CYS 
_pdbx_modification_feature.label_asym_id                      A 
_pdbx_modification_feature.label_seq_id                       40 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      78 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       CYS 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        40 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       78 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               SG 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                . 
_pdbx_modification_feature.ref_pcm_id                         . 
_pdbx_modification_feature.ref_comp_id                        . 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Disulfide bridge' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 10 ? 
AA2 ? 2  ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2  ? anti-parallel 
AA1 2 3  ? anti-parallel 
AA1 3 4  ? parallel      
AA1 4 5  ? parallel      
AA1 5 6  ? parallel      
AA1 6 7  ? parallel      
AA1 7 8  ? parallel      
AA1 8 9  ? anti-parallel 
AA1 9 10 ? anti-parallel 
AA2 1 2  ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1  GLN A 5   ? THR A 10  ? GLN A 5   THR A 10  
AA1 2  VAL A 16  ? ILE A 21  ? VAL A 16  ILE A 21  
AA1 3  LEU A 63  ? PRO A 67  ? LEU A 63  PRO A 67  
AA1 4  LEU A 31  ? LEU A 37  ? LEU A 31  LEU A 37  
AA1 5  VAL A 110 ? LEU A 120 ? VAL A 110 LEU A 120 
AA1 6  ALA A 140 ? GLY A 144 ? ALA A 140 GLY A 144 
AA1 7  VAL A 189 ? GLY A 194 ? VAL A 189 GLY A 194 
AA1 8  VAL A 258 ? VAL A 265 ? VAL A 258 VAL A 265 
AA1 9  THR A 245 ? LYS A 252 ? THR A 245 LYS A 252 
AA1 10 VAL A 234 ? SER A 239 ? VAL A 234 SER A 239 
AA2 1  TRP A 272 ? SER A 273 ? TRP A 272 SER A 273 
AA2 2  THR A 282 ? ASP A 283 ? THR A 282 ASP A 283 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2  N ASP A 9   ? N ASP A 9   O TYR A 17  ? O TYR A 17  
AA1 2 3  N LYS A 18  ? N LYS A 18  O TYR A 66  ? O TYR A 66  
AA1 3 4  O ALA A 65  ? O ALA A 65  N MET A 36  ? N MET A 36  
AA1 4 5  N LEU A 37  ? N LEU A 37  O ALA A 118 ? O ALA A 118 
AA1 5 6  N GLY A 119 ? N GLY A 119 O GLY A 144 ? O GLY A 144 
AA1 6 7  N VAL A 143 ? N VAL A 143 O ILE A 190 ? O ILE A 190 
AA1 7 8  N VAL A 191 ? N VAL A 191 O ILE A 263 ? O ILE A 263 
AA1 8 9  O VAL A 259 ? O VAL A 259 N TYR A 251 ? N TYR A 251 
AA1 9 10 O ARG A 248 ? O ARG A 248 N MET A 236 ? N MET A 236 
AA2 1 2  N TRP A 272 ? N TRP A 272 O ASP A 283 ? O ASP A 283 
# 
_pdbx_entry_details.entry_id                   9BYU 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    OD1 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    ASN 
_pdbx_validate_symm_contact.auth_seq_id_1     76 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    B 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    NH1 
_pdbx_validate_symm_contact.auth_asym_id_2    A 
_pdbx_validate_symm_contact.auth_comp_id_2    ARG 
_pdbx_validate_symm_contact.auth_seq_id_2     114 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   6_554 
_pdbx_validate_symm_contact.dist              1.93 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 THR A 41  ? ? 72.25  -9.89   
2 1 SER A 121 ? ? 60.89  -121.73 
3 1 SER A 121 ? ? 59.59  -120.90 
4 1 ASP A 168 ? ? -36.85 114.02  
5 1 THR A 199 ? ? -99.45 -64.08  
6 1 ASN A 242 ? A 59.03  19.36   
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 553 ? D HOH . 
2 1 A HOH 737 ? D HOH . 
3 1 A HOH 747 ? D HOH . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z         
2 x-y,x,z+2/3   
3 y,-x+y,z+1/3  
4 -y,x-y,z+1/3  
5 -x+y,-x,z+2/3 
6 -x,-y,z       
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A VAL 223 ? A VAL 223 
2 1 Y 1 A ASP 224 ? A ASP 224 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
GLN N    N  N N 88  
GLN CA   C  N S 89  
GLN C    C  N N 90  
GLN O    O  N N 91  
GLN CB   C  N N 92  
GLN CG   C  N N 93  
GLN CD   C  N N 94  
GLN OE1  O  N N 95  
GLN NE2  N  N N 96  
GLN OXT  O  N N 97  
GLN H    H  N N 98  
GLN H2   H  N N 99  
GLN HA   H  N N 100 
GLN HB2  H  N N 101 
GLN HB3  H  N N 102 
GLN HG2  H  N N 103 
GLN HG3  H  N N 104 
GLN HE21 H  N N 105 
GLN HE22 H  N N 106 
GLN HXT  H  N N 107 
GLU N    N  N N 108 
GLU CA   C  N S 109 
GLU C    C  N N 110 
GLU O    O  N N 111 
GLU CB   C  N N 112 
GLU CG   C  N N 113 
GLU CD   C  N N 114 
GLU OE1  O  N N 115 
GLU OE2  O  N N 116 
GLU OXT  O  N N 117 
GLU H    H  N N 118 
GLU H2   H  N N 119 
GLU HA   H  N N 120 
GLU HB2  H  N N 121 
GLU HB3  H  N N 122 
GLU HG2  H  N N 123 
GLU HG3  H  N N 124 
GLU HE2  H  N N 125 
GLU HXT  H  N N 126 
GLY N    N  N N 127 
GLY CA   C  N N 128 
GLY C    C  N N 129 
GLY O    O  N N 130 
GLY OXT  O  N N 131 
GLY H    H  N N 132 
GLY H2   H  N N 133 
GLY HA2  H  N N 134 
GLY HA3  H  N N 135 
GLY HXT  H  N N 136 
HIS N    N  N N 137 
HIS CA   C  N S 138 
HIS C    C  N N 139 
HIS O    O  N N 140 
HIS CB   C  N N 141 
HIS CG   C  Y N 142 
HIS ND1  N  Y N 143 
HIS CD2  C  Y N 144 
HIS CE1  C  Y N 145 
HIS NE2  N  Y N 146 
HIS OXT  O  N N 147 
HIS H    H  N N 148 
HIS H2   H  N N 149 
HIS HA   H  N N 150 
HIS HB2  H  N N 151 
HIS HB3  H  N N 152 
HIS HD1  H  N N 153 
HIS HD2  H  N N 154 
HIS HE1  H  N N 155 
HIS HE2  H  N N 156 
HIS HXT  H  N N 157 
HOH O    O  N N 158 
HOH H1   H  N N 159 
HOH H2   H  N N 160 
ILE N    N  N N 161 
ILE CA   C  N S 162 
ILE C    C  N N 163 
ILE O    O  N N 164 
ILE CB   C  N S 165 
ILE CG1  C  N N 166 
ILE CG2  C  N N 167 
ILE CD1  C  N N 168 
ILE OXT  O  N N 169 
ILE H    H  N N 170 
ILE H2   H  N N 171 
ILE HA   H  N N 172 
ILE HB   H  N N 173 
ILE HG12 H  N N 174 
ILE HG13 H  N N 175 
ILE HG21 H  N N 176 
ILE HG22 H  N N 177 
ILE HG23 H  N N 178 
ILE HD11 H  N N 179 
ILE HD12 H  N N 180 
ILE HD13 H  N N 181 
ILE HXT  H  N N 182 
LEU N    N  N N 183 
LEU CA   C  N S 184 
LEU C    C  N N 185 
LEU O    O  N N 186 
LEU CB   C  N N 187 
LEU CG   C  N N 188 
LEU CD1  C  N N 189 
LEU CD2  C  N N 190 
LEU OXT  O  N N 191 
LEU H    H  N N 192 
LEU H2   H  N N 193 
LEU HA   H  N N 194 
LEU HB2  H  N N 195 
LEU HB3  H  N N 196 
LEU HG   H  N N 197 
LEU HD11 H  N N 198 
LEU HD12 H  N N 199 
LEU HD13 H  N N 200 
LEU HD21 H  N N 201 
LEU HD22 H  N N 202 
LEU HD23 H  N N 203 
LEU HXT  H  N N 204 
LYS N    N  N N 205 
LYS CA   C  N S 206 
LYS C    C  N N 207 
LYS O    O  N N 208 
LYS CB   C  N N 209 
LYS CG   C  N N 210 
LYS CD   C  N N 211 
LYS CE   C  N N 212 
LYS NZ   N  N N 213 
LYS OXT  O  N N 214 
LYS H    H  N N 215 
LYS H2   H  N N 216 
LYS HA   H  N N 217 
LYS HB2  H  N N 218 
LYS HB3  H  N N 219 
LYS HG2  H  N N 220 
LYS HG3  H  N N 221 
LYS HD2  H  N N 222 
LYS HD3  H  N N 223 
LYS HE2  H  N N 224 
LYS HE3  H  N N 225 
LYS HZ1  H  N N 226 
LYS HZ2  H  N N 227 
LYS HZ3  H  N N 228 
LYS HXT  H  N N 229 
MET N    N  N N 230 
MET CA   C  N S 231 
MET C    C  N N 232 
MET O    O  N N 233 
MET CB   C  N N 234 
MET CG   C  N N 235 
MET SD   S  N N 236 
MET CE   C  N N 237 
MET OXT  O  N N 238 
MET H    H  N N 239 
MET H2   H  N N 240 
MET HA   H  N N 241 
MET HB2  H  N N 242 
MET HB3  H  N N 243 
MET HG2  H  N N 244 
MET HG3  H  N N 245 
MET HE1  H  N N 246 
MET HE2  H  N N 247 
MET HE3  H  N N 248 
MET HXT  H  N N 249 
MG  MG   MG N N 250 
PHE N    N  N N 251 
PHE CA   C  N S 252 
PHE C    C  N N 253 
PHE O    O  N N 254 
PHE CB   C  N N 255 
PHE CG   C  Y N 256 
PHE CD1  C  Y N 257 
PHE CD2  C  Y N 258 
PHE CE1  C  Y N 259 
PHE CE2  C  Y N 260 
PHE CZ   C  Y N 261 
PHE OXT  O  N N 262 
PHE H    H  N N 263 
PHE H2   H  N N 264 
PHE HA   H  N N 265 
PHE HB2  H  N N 266 
PHE HB3  H  N N 267 
PHE HD1  H  N N 268 
PHE HD2  H  N N 269 
PHE HE1  H  N N 270 
PHE HE2  H  N N 271 
PHE HZ   H  N N 272 
PHE HXT  H  N N 273 
PRO N    N  N N 274 
PRO CA   C  N S 275 
PRO C    C  N N 276 
PRO O    O  N N 277 
PRO CB   C  N N 278 
PRO CG   C  N N 279 
PRO CD   C  N N 280 
PRO OXT  O  N N 281 
PRO H    H  N N 282 
PRO HA   H  N N 283 
PRO HB2  H  N N 284 
PRO HB3  H  N N 285 
PRO HG2  H  N N 286 
PRO HG3  H  N N 287 
PRO HD2  H  N N 288 
PRO HD3  H  N N 289 
PRO HXT  H  N N 290 
SER N    N  N N 291 
SER CA   C  N S 292 
SER C    C  N N 293 
SER O    O  N N 294 
SER CB   C  N N 295 
SER OG   O  N N 296 
SER OXT  O  N N 297 
SER H    H  N N 298 
SER H2   H  N N 299 
SER HA   H  N N 300 
SER HB2  H  N N 301 
SER HB3  H  N N 302 
SER HG   H  N N 303 
SER HXT  H  N N 304 
THR N    N  N N 305 
THR CA   C  N S 306 
THR C    C  N N 307 
THR O    O  N N 308 
THR CB   C  N R 309 
THR OG1  O  N N 310 
THR CG2  C  N N 311 
THR OXT  O  N N 312 
THR H    H  N N 313 
THR H2   H  N N 314 
THR HA   H  N N 315 
THR HB   H  N N 316 
THR HG1  H  N N 317 
THR HG21 H  N N 318 
THR HG22 H  N N 319 
THR HG23 H  N N 320 
THR HXT  H  N N 321 
TRP N    N  N N 322 
TRP CA   C  N S 323 
TRP C    C  N N 324 
TRP O    O  N N 325 
TRP CB   C  N N 326 
TRP CG   C  Y N 327 
TRP CD1  C  Y N 328 
TRP CD2  C  Y N 329 
TRP NE1  N  Y N 330 
TRP CE2  C  Y N 331 
TRP CE3  C  Y N 332 
TRP CZ2  C  Y N 333 
TRP CZ3  C  Y N 334 
TRP CH2  C  Y N 335 
TRP OXT  O  N N 336 
TRP H    H  N N 337 
TRP H2   H  N N 338 
TRP HA   H  N N 339 
TRP HB2  H  N N 340 
TRP HB3  H  N N 341 
TRP HD1  H  N N 342 
TRP HE1  H  N N 343 
TRP HE3  H  N N 344 
TRP HZ2  H  N N 345 
TRP HZ3  H  N N 346 
TRP HH2  H  N N 347 
TRP HXT  H  N N 348 
TRS C    C  N N 349 
TRS C1   C  N N 350 
TRS C2   C  N N 351 
TRS C3   C  N N 352 
TRS N    N  N N 353 
TRS O1   O  N N 354 
TRS O2   O  N N 355 
TRS O3   O  N N 356 
TRS H11  H  N N 357 
TRS H12  H  N N 358 
TRS H21  H  N N 359 
TRS H22  H  N N 360 
TRS H31  H  N N 361 
TRS H32  H  N N 362 
TRS HN1  H  N N 363 
TRS HN2  H  N N 364 
TRS HN3  H  N N 365 
TRS HO1  H  N N 366 
TRS HO2  H  N N 367 
TRS HO3  H  N N 368 
TYR N    N  N N 369 
TYR CA   C  N S 370 
TYR C    C  N N 371 
TYR O    O  N N 372 
TYR CB   C  N N 373 
TYR CG   C  Y N 374 
TYR CD1  C  Y N 375 
TYR CD2  C  Y N 376 
TYR CE1  C  Y N 377 
TYR CE2  C  Y N 378 
TYR CZ   C  Y N 379 
TYR OH   O  N N 380 
TYR OXT  O  N N 381 
TYR H    H  N N 382 
TYR H2   H  N N 383 
TYR HA   H  N N 384 
TYR HB2  H  N N 385 
TYR HB3  H  N N 386 
TYR HD1  H  N N 387 
TYR HD2  H  N N 388 
TYR HE1  H  N N 389 
TYR HE2  H  N N 390 
TYR HH   H  N N 391 
TYR HXT  H  N N 392 
VAL N    N  N N 393 
VAL CA   C  N S 394 
VAL C    C  N N 395 
VAL O    O  N N 396 
VAL CB   C  N N 397 
VAL CG1  C  N N 398 
VAL CG2  C  N N 399 
VAL OXT  O  N N 400 
VAL H    H  N N 401 
VAL H2   H  N N 402 
VAL HA   H  N N 403 
VAL HB   H  N N 404 
VAL HG11 H  N N 405 
VAL HG12 H  N N 406 
VAL HG13 H  N N 407 
VAL HG21 H  N N 408 
VAL HG22 H  N N 409 
VAL HG23 H  N N 410 
VAL HXT  H  N N 411 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TRS C   C1   sing N N 334 
TRS C   C2   sing N N 335 
TRS C   C3   sing N N 336 
TRS C   N    sing N N 337 
TRS C1  O1   sing N N 338 
TRS C1  H11  sing N N 339 
TRS C1  H12  sing N N 340 
TRS C2  O2   sing N N 341 
TRS C2  H21  sing N N 342 
TRS C2  H22  sing N N 343 
TRS C3  O3   sing N N 344 
TRS C3  H31  sing N N 345 
TRS C3  H32  sing N N 346 
TRS N   HN1  sing N N 347 
TRS N   HN2  sing N N 348 
TRS N   HN3  sing N N 349 
TRS O1  HO1  sing N N 350 
TRS O2  HO2  sing N N 351 
TRS O3  HO3  sing N N 352 
TYR N   CA   sing N N 353 
TYR N   H    sing N N 354 
TYR N   H2   sing N N 355 
TYR CA  C    sing N N 356 
TYR CA  CB   sing N N 357 
TYR CA  HA   sing N N 358 
TYR C   O    doub N N 359 
TYR C   OXT  sing N N 360 
TYR CB  CG   sing N N 361 
TYR CB  HB2  sing N N 362 
TYR CB  HB3  sing N N 363 
TYR CG  CD1  doub Y N 364 
TYR CG  CD2  sing Y N 365 
TYR CD1 CE1  sing Y N 366 
TYR CD1 HD1  sing N N 367 
TYR CD2 CE2  doub Y N 368 
TYR CD2 HD2  sing N N 369 
TYR CE1 CZ   doub Y N 370 
TYR CE1 HE1  sing N N 371 
TYR CE2 CZ   sing Y N 372 
TYR CE2 HE2  sing N N 373 
TYR CZ  OH   sing N N 374 
TYR OH  HH   sing N N 375 
TYR OXT HXT  sing N N 376 
VAL N   CA   sing N N 377 
VAL N   H    sing N N 378 
VAL N   H2   sing N N 379 
VAL CA  C    sing N N 380 
VAL CA  CB   sing N N 381 
VAL CA  HA   sing N N 382 
VAL C   O    doub N N 383 
VAL C   OXT  sing N N 384 
VAL CB  CG1  sing N N 385 
VAL CB  CG2  sing N N 386 
VAL CB  HB   sing N N 387 
VAL CG1 HG11 sing N N 388 
VAL CG1 HG12 sing N N 389 
VAL CG1 HG13 sing N N 390 
VAL CG2 HG21 sing N N 391 
VAL CG2 HG22 sing N N 392 
VAL CG2 HG23 sing N N 393 
VAL OXT HXT  sing N N 394 
# 
_pdbx_audit_support.funding_organization   'National Science Foundation (NSF, United States)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   8daj 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 64' 
_space_group.name_Hall        'P 64' 
_space_group.IT_number        172 
_space_group.crystal_system   hexagonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    9BYU 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.011289 
_atom_sites.fract_transf_matrix[1][2]   0.006517 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.013035 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.020073 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H  ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
MG ? ? 9.41153 2.53737 ? ? 2.59044  63.03566 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . GLY A 1 1   ? -12.22803 8.98855  21.63040  1.000 54.02801 ? 1   GLY A N   1 
ATOM   2    C  CA  . GLY A 1 1   ? -12.65879 8.83874  23.00974  1.000 62.75120 ? 1   GLY A CA  1 
ATOM   3    C  C   . GLY A 1 1   ? -14.12974 9.15109  23.23524  1.000 61.25095 ? 1   GLY A C   1 
ATOM   4    O  O   . GLY A 1 1   ? -14.93487 8.24509  23.46322  1.000 68.24462 ? 1   GLY A O   1 
ATOM   5    N  N   . PRO A 1 2   ? -14.48208 10.43333 23.19755  1.000 59.63095 ? 2   PRO A N   1 
ATOM   6    C  CA  . PRO A 1 2   ? -15.89585 10.81386 23.31465  1.000 47.97718 ? 2   PRO A CA  1 
ATOM   7    C  C   . PRO A 1 2   ? -16.73796 10.05040 22.30058  1.000 54.68585 ? 2   PRO A C   1 
ATOM   8    O  O   . PRO A 1 2   ? -16.41903 10.00682 21.10814  1.000 42.12550 ? 2   PRO A O   1 
ATOM   9    C  CB  . PRO A 1 2   ? -15.88683 12.32158 23.02704  1.000 51.07208 ? 2   PRO A CB  1 
ATOM   10   C  CG  . PRO A 1 2   ? -14.44469 12.67704 22.66629  1.000 42.12755 ? 2   PRO A CG  1 
ATOM   11   C  CD  . PRO A 1 2   ? -13.58488 11.59890 23.20839  1.000 49.32799 ? 2   PRO A CD  1 
ATOM   12   N  N   . ALA A 1 3   ? -17.81720 9.43428  22.78231  1.000 48.35845 ? 3   ALA A N   1 
ATOM   13   C  CA  . ALA A 1 3   ? -18.64795 8.54959  21.97360  1.000 34.33466 ? 3   ALA A CA  1 
ATOM   14   C  C   . ALA A 1 3   ? -20.09261 9.02782  21.99845  1.000 31.47917 ? 3   ALA A C   1 
ATOM   15   O  O   . ALA A 1 3   ? -20.62715 9.35800  23.06363  1.000 26.03455 ? 3   ALA A O   1 
ATOM   16   C  CB  . ALA A 1 3   ? -18.56194 7.10346  22.47575  1.000 31.35799 ? 3   ALA A CB  1 
ATOM   17   N  N   . GLY A 1 4   ? -20.71960 9.06281  20.83033  1.000 22.36879 ? 4   GLY A N   1 
ATOM   18   C  CA  . GLY A 1 4   ? -22.13278 9.34604  20.72184  1.000 20.52851 ? 4   GLY A CA  1 
ATOM   19   C  C   . GLY A 1 4   ? -22.94174 8.06509  20.77409  1.000 22.65804 ? 4   GLY A C   1 
ATOM   20   O  O   . GLY A 1 4   ? -22.47473 7.01741  21.22612  1.000 21.89985 ? 4   GLY A O   1 
ATOM   21   N  N   . GLN A 1 5   ? -24.17163 8.15003  20.29146  1.000 20.49538 ? 5   GLN A N   1 
ATOM   22   C  CA  . GLN A 1 5   ? -25.05368 6.99919  20.27860  1.000 19.14654 ? 5   GLN A CA  1 
ATOM   23   C  C   . GLN A 1 5   ? -25.72034 6.87755  18.91582  1.000 19.71365 ? 5   GLN A C   1 
ATOM   24   O  O   . GLN A 1 5   ? -26.05617 7.87212  18.27114  1.000 18.40663 ? 5   GLN A O   1 
ATOM   25   C  CB  . GLN A 1 5   ? -26.12735 7.10431  21.35494  1.000 22.61531 ? 5   GLN A CB  1 
ATOM   26   C  CG  . GLN A 1 5   ? -26.75124 8.47141  21.40590  1.000 18.03814 ? 5   GLN A CG  1 
ATOM   27   C  CD  . GLN A 1 5   ? -27.64509 8.66589  22.60579  1.000 39.28258 ? 5   GLN A CD  1 
ATOM   28   O  OE1 . GLN A 1 5   ? -27.61988 9.71927  23.25111  1.000 37.45323 ? 5   GLN A OE1 1 
ATOM   29   N  NE2 . GLN A 1 5   ? -28.48248 7.67316  22.88330  1.000 29.52509 ? 5   GLN A NE2 1 
ATOM   30   N  N   . PHE A 1 6   ? -25.94992 5.63970  18.50878  1.000 16.84863 ? 6   PHE A N   1 
ATOM   31   C  CA  . PHE A 1 6   ? -26.57927 5.31955  17.23727  1.000 12.69415 ? 6   PHE A CA  1 
ATOM   32   C  C   . PHE A 1 6   ? -27.87367 4.59026  17.57273  1.000 15.91400 ? 6   PHE A C   1 
ATOM   33   O  O   . PHE A 1 6   ? -27.84526 3.47129  18.10132  1.000 15.98198 ? 6   PHE A O   1 
ATOM   34   C  CB  . PHE A 1 6   ? -25.62056 4.48068  16.38735  1.000 12.95485 ? 6   PHE A CB  1 
ATOM   35   C  CG  . PHE A 1 6   ? -25.92111 4.47930  14.90829  1.000 11.77283 ? 6   PHE A CG  1 
ATOM   36   C  CD1 . PHE A 1 6   ? -26.67064 5.48579  14.31692  1.000 10.68207 ? 6   PHE A CD1 1 
ATOM   37   C  CD2 . PHE A 1 6   ? -25.41202 3.46443  14.10116  1.000 13.78541 ? 6   PHE A CD2 1 
ATOM   38   C  CE1 . PHE A 1 6   ? -26.92440 5.47192  12.93925  1.000 14.77735 ? 6   PHE A CE1 1 
ATOM   39   C  CE2 . PHE A 1 6   ? -25.64906 3.43965  12.74311  1.000 15.60415 ? 6   PHE A CE2 1 
ATOM   40   C  CZ  . PHE A 1 6   ? -26.41705 4.43882  12.15379  1.000 16.77002 ? 6   PHE A CZ  1 
ATOM   41   N  N   . ILE A 1 7   ? -29.00408 5.24088  17.32691  1.000 13.00151 ? 7   ILE A N   1 
ATOM   42   C  CA  . ILE A 1 7   ? -30.28801 4.72382  17.76037  1.000 11.82258 ? 7   ILE A CA  1 
ATOM   43   C  C   . ILE A 1 7   ? -31.06946 4.30504  16.52834  1.000 19.40373 ? 7   ILE A C   1 
ATOM   44   O  O   . ILE A 1 7   ? -30.80663 4.74488  15.40504  1.000 18.57114 ? 7   ILE A O   1 
ATOM   45   C  CB  . ILE A 1 7   ? -31.08178 5.74988  18.58858  1.000 15.75660 ? 7   ILE A CB  1 
ATOM   46   C  CG1 . ILE A 1 7   ? -31.47257 6.94030  17.71252  1.000 18.71961 ? 7   ILE A CG1 1 
ATOM   47   C  CG2 . ILE A 1 7   ? -30.24044 6.21547  19.77929  1.000 17.92697 ? 7   ILE A CG2 1 
ATOM   48   C  CD1 . ILE A 1 7   ? -32.15446 8.07618  18.45817  1.000 35.20935 ? 7   ILE A CD1 1 
ATOM   49   N  N   . ARG A 1 8   ? -32.03331 3.42443  16.74305  1.000 14.51053 ? 8   ARG A N   1 
ATOM   50   C  CA  . ARG A 1 8   ? -32.97967 3.05277  15.70877  1.000 14.72353 ? 8   ARG A CA  1 
ATOM   51   C  C   . ARG A 1 8   ? -34.36518 3.50541  16.15034  1.000 18.66462 ? 8   ARG A C   1 
ATOM   52   O  O   . ARG A 1 8   ? -34.74271 3.31733  17.31041  1.000 17.23735 ? 8   ARG A O   1 
ATOM   53   C  CB  . ARG A 1 8   ? -32.90072 1.54790  15.45176  1.000 18.49157 ? 8   ARG A CB  1 
ATOM   54   C  CG  . ARG A 1 8   ? -33.81989 1.03684  14.40177  1.000 18.96805 ? 8   ARG A CG  1 
ATOM   55   C  CD  . ARG A 1 8   ? -34.40102 -0.29254 14.81567  1.000 29.66859 ? 8   ARG A CD  1 
ATOM   56   N  NE  . ARG A 1 8   ? -34.73619 -1.08997 13.64365  1.000 26.32588 ? 8   ARG A NE  1 
ATOM   57   C  CZ  . ARG A 1 8   ? -35.97009 -1.47493 13.35793  1.000 17.90385 ? 8   ARG A CZ  1 
ATOM   58   N  NH1 . ARG A 1 8   ? -36.98792 -1.16038 14.14173  1.000 32.13825 ? 8   ARG A NH1 1 
ATOM   59   N  NH2 . ARG A 1 8   ? -36.19129 -2.17362 12.25076  1.000 31.76674 ? 8   ARG A NH2 1 
ATOM   60   N  N   . ASP A 1 9   ? -35.11154 4.13019  15.24422  1.000 16.29853 ? 9   ASP A N   1 
ATOM   61   C  CA  . ASP A 1 9   ? -36.46241 4.56927  15.55950  1.000 17.93647 ? 9   ASP A CA  1 
ATOM   62   C  C   . ASP A 1 9   ? -37.37192 4.29418  14.36831  1.000 20.22167 ? 9   ASP A C   1 
ATOM   63   O  O   . ASP A 1 9   ? -36.93341 3.85136  13.30307  1.000 19.18726 ? 9   ASP A O   1 
ATOM   64   C  CB  . ASP A 1 9   ? -36.48367 6.05437  15.95411  1.000 17.51636 ? 9   ASP A CB  1 
ATOM   65   C  CG  . ASP A 1 9   ? -37.53524 6.37885  17.00450  1.000 28.01585 ? 9   ASP A CG  1 
ATOM   66   O  OD1 . ASP A 1 9   ? -38.50081 5.59752  17.18314  1.000 26.61201 ? 9   ASP A OD1 1 
ATOM   67   O  OD2 . ASP A 1 9   ? -37.40035 7.44311  17.63852  1.000 34.50477 ? 9   ASP A OD2 1 
ATOM   68   N  N   . THR A 1 10  ? -38.66326 4.54127  14.57011  1.000 14.77159 ? 10  THR A N   1 
ATOM   69   C  CA  . THR A 1 10  ? -39.67112 4.41017  13.52722  1.000 16.84944 ? 10  THR A CA  1 
ATOM   70   C  C   . THR A 1 10  ? -40.49807 5.68750  13.50832  1.000 22.18785 ? 10  THR A C   1 
ATOM   71   O  O   . THR A 1 10  ? -41.06136 6.07866  14.53622  1.000 20.39648 ? 10  THR A O   1 
ATOM   72   C  CB  . THR A 1 10  ? -40.55972 3.18434  13.77351  1.000 25.89860 ? 10  THR A CB  1 
ATOM   73   O  OG1 . THR A 1 10  ? -39.72704 2.05788  14.05497  1.000 22.13602 ? 10  THR A OG1 1 
ATOM   74   C  CG2 . THR A 1 10  ? -41.39041 2.86081  12.54834  1.000 20.74555 ? 10  THR A CG2 1 
ATOM   75   N  N   . ALA A 1 11  ? -40.54789 6.35195  12.35870  1.000 17.43026 ? 11  ALA A N   1 
ATOM   76   C  CA  . ALA A 1 11  ? -41.36560 7.54213  12.23433  1.000 22.52849 ? 11  ALA A CA  1 
ATOM   77   C  C   . ALA A 1 11  ? -42.84136 7.15202  12.20999  1.000 14.82955 ? 11  ALA A C   1 
ATOM   78   O  O   . ALA A 1 11  ? -43.18738 5.97844  12.03672  1.000 17.67725 ? 11  ALA A O   1 
ATOM   79   C  CB  . ALA A 1 11  ? -40.99305 8.32919  10.97691  1.000 18.54801 ? 11  ALA A CB  1 
ATOM   80   N  N   . PRO A 1 12  ? -43.73492 8.13207  12.38132  1.000 18.65883 ? 12  PRO A N   1 
ATOM   81   C  CA  . PRO A 1 12  ? -45.17381 7.82366  12.45290  1.000 19.32140 ? 12  PRO A CA  1 
ATOM   82   C  C   . PRO A 1 12  ? -45.72100 7.07162  11.25084  1.000 27.30693 ? 12  PRO A C   1 
ATOM   83   O  O   . PRO A 1 12  ? -46.74705 6.39157  11.38301  1.000 20.18972 ? 12  PRO A O   1 
ATOM   84   C  CB  . PRO A 1 12  ? -45.80653 9.21720  12.57754  1.000 18.71286 ? 12  PRO A CB  1 
ATOM   85   C  CG  . PRO A 1 12  ? -44.80180 10.00596 13.31112  1.000 24.37170 ? 12  PRO A CG  1 
ATOM   86   C  CD  . PRO A 1 12  ? -43.45190 9.51566  12.80895  1.000 22.11593 ? 12  PRO A CD  1 
ATOM   87   N  N   . ASP A 1 13  ? -45.10720 7.18913  10.07365  1.000 21.55501 ? 13  ASP A N   1 
ATOM   88   C  CA  . ASP A 1 13  ? -45.61390 6.48786  8.90462   1.000 14.10853 ? 13  ASP A CA  1 
ATOM   89   C  C   . ASP A 1 13  ? -45.04206 5.08769  8.76909   1.000 20.09784 ? 13  ASP A C   1 
ATOM   90   O  O   . ASP A 1 13  ? -45.28142 4.42895  7.75064   1.000 18.92889 ? 13  ASP A O   1 
ATOM   91   C  CB  . ASP A 1 13  ? -45.33895 7.28029  7.62204   1.000 14.24313 ? 13  ASP A CB  1 
ATOM   92   C  CG  . ASP A 1 13  ? -43.86913 7.32309  7.25101   1.000 16.15358 ? 13  ASP A CG  1 
ATOM   93   O  OD1 . ASP A 1 13  ? -43.01486 6.93929  8.07741   1.000 13.85431 ? 13  ASP A OD1 1 
ATOM   94   O  OD2 . ASP A 1 13  ? -43.56881 7.72611  6.10631   1.000 17.13364 ? 13  ASP A OD2 1 
ATOM   95   N  N   . GLY A 1 14  ? -44.28526 4.62417  9.75957   1.000 11.44910 ? 14  GLY A N   1 
ATOM   96   C  CA  . GLY A 1 14  ? -43.67802 3.31130  9.69717   1.000 18.27870 ? 14  GLY A CA  1 
ATOM   97   C  C   . GLY A 1 14  ? -42.26825 3.29868  9.15966   1.000 21.72208 ? 14  GLY A C   1 
ATOM   98   O  O   . GLY A 1 14  ? -41.64804 2.23025  9.12298   1.000 16.45521 ? 14  GLY A O   1 
ATOM   99   N  N   . ARG A 1 15  ? -41.73411 4.45373  8.73959   1.000 17.75842 ? 15  ARG A N   1 
ATOM   100  C  CA  . ARG A 1 15  ? -40.37617 4.48550  8.21625   1.000 15.18292 ? 15  ARG A CA  1 
ATOM   101  C  C   . ARG A 1 15  ? -39.37970 4.24987  9.34029   1.000 13.66200 ? 15  ARG A C   1 
ATOM   102  O  O   . ARG A 1 15  ? -39.29523 5.04408  10.28045  1.000 16.00493 ? 15  ARG A O   1 
ATOM   103  C  CB  . ARG A 1 15  ? -40.08800 5.81701  7.52360   1.000 15.26373 ? 15  ARG A CB  1 
ATOM   104  C  CG  . ARG A 1 15  ? -38.64247 5.92547  7.04792   1.000 17.14731 ? 15  ARG A CG  1 
ATOM   105  C  CD  . ARG A 1 15  ? -38.41331 5.01229  5.84556   1.000 13.03222 ? 15  ARG A CD  1 
ATOM   106  N  NE  . ARG A 1 15  ? -39.42810 5.24143  4.82562   1.000 13.41789 ? 15  ARG A NE  1 
ATOM   107  C  CZ  . ARG A 1 15  ? -39.50660 4.58238  3.68120   1.000 11.25246 ? 15  ARG A CZ  1 
ATOM   108  N  NH1 . ARG A 1 15  ? -38.61807 3.66131  3.35570   1.000 11.50007 ? 15  ARG A NH1 1 
ATOM   109  N  NH2 . ARG A 1 15  ? -40.49186 4.87065  2.83229   1.000 13.56108 ? 15  ARG A NH2 1 
ATOM   110  N  N   . VAL A 1 16  ? -38.61969 3.17232  9.23251   1.000 12.70370 ? 16  VAL A N   1 
ATOM   111  C  CA  . VAL A 1 16  ? -37.51793 2.92347  10.14651  1.000 12.09476 ? 16  VAL A CA  1 
ATOM   112  C  C   . VAL A 1 16  ? -36.35334 3.81878  9.74453   1.000 16.55575 ? 16  VAL A C   1 
ATOM   113  O  O   . VAL A 1 16  ? -36.11009 4.06092  8.55719   1.000 12.63010 ? 16  VAL A O   1 
ATOM   114  C  CB  . VAL A 1 16  ? -37.12724 1.43331  10.11531  1.000 16.27920 ? 16  VAL A CB  1 
ATOM   115  C  CG1 . VAL A 1 16  ? -35.83006 1.19354  10.86973  1.000 19.35968 ? 16  VAL A CG1 1 
ATOM   116  C  CG2 . VAL A 1 16  ? -38.26680 0.56469  10.66939  1.000 17.28296 ? 16  VAL A CG2 1 
ATOM   117  N  N   . TYR A 1 17  ? -35.64269 4.34715  10.72939  1.000 11.47314 ? 17  TYR A N   1 
ATOM   118  C  CA  . TYR A 1 17  ? -34.42828 5.08106  10.42488  1.000 14.15351 ? 17  TYR A CA  1 
ATOM   119  C  C   . TYR A 1 17  ? -33.50791 4.99091  11.62656  1.000 13.11740 ? 17  TYR A C   1 
ATOM   120  O  O   . TYR A 1 17  ? -33.94817 4.76791  12.75417  1.000 17.16028 ? 17  TYR A O   1 
ATOM   121  C  CB  . TYR A 1 17  ? -34.72123 6.54477  10.07087  1.000 13.42887 ? 17  TYR A CB  1 
ATOM   122  C  CG  . TYR A 1 17  ? -35.27788 7.37241  11.21700  1.000 13.41815 ? 17  TYR A CG  1 
ATOM   123  C  CD1 . TYR A 1 17  ? -36.65248 7.39434  11.48538  1.000 16.06862 ? 17  TYR A CD1 1 
ATOM   124  C  CD2 . TYR A 1 17  ? -34.43078 8.11747  12.04444  1.000 13.97073 ? 17  TYR A CD2 1 
ATOM   125  C  CE1 . TYR A 1 17  ? -37.17550 8.15984  12.52401  1.000 11.84122 ? 17  TYR A CE1 1 
ATOM   126  C  CE2 . TYR A 1 17  ? -34.94180 8.88739  13.07969  1.000 11.97761 ? 17  TYR A CE2 1 
ATOM   127  C  CZ  . TYR A 1 17  ? -36.31387 8.89655  13.31630  1.000 14.42705 ? 17  TYR A CZ  1 
ATOM   128  O  OH  . TYR A 1 17  ? -36.82935 9.65701  14.33548  1.000 16.97834 ? 17  TYR A OH  1 
ATOM   129  N  N   . LYS A 1 18  ? -32.21923 5.13628  11.37453  1.000 12.91526 ? 18  LYS A N   1 
ATOM   130  C  CA  . LYS A 1 18  ? -31.24917 5.19494  12.44761  1.000 11.10755 ? 18  LYS A CA  1 
ATOM   131  C  C   . LYS A 1 18  ? -30.75122 6.62954  12.54845  1.000 13.51766 ? 18  LYS A C   1 
ATOM   132  O  O   . LYS A 1 18  ? -30.78912 7.39214  11.57323  1.000 11.98873 ? 18  LYS A O   1 
ATOM   133  C  CB  . LYS A 1 18  ? -30.10302 4.20228  12.20678  1.000 11.62782 ? 18  LYS A CB  1 
ATOM   134  C  CG  . LYS A 1 18  ? -30.57466 2.72711  12.36178  1.000 12.52683 ? 18  LYS A CG  1 
ATOM   135  C  CD  . LYS A 1 18  ? -29.39837 1.78966  12.50949  1.000 13.76894 ? 18  LYS A CD  1 
ATOM   136  C  CE  . LYS A 1 18  ? -28.86787 1.76462  13.94893  1.000 17.23511 ? 18  LYS A CE  1 
ATOM   137  N  NZ  . LYS A 1 18  ? -28.08482 0.51675  14.19567  1.000 12.07955 ? 18  LYS A NZ  1 
ATOM   138  N  N   . LEU A 1 19  ? -30.33208 7.00292  13.74938  1.000 8.53070  ? 19  LEU A N   1 
ATOM   139  C  CA  . LEU A 1 19  ? -29.94292 8.37493  14.03971  1.000 8.89908  ? 19  LEU A CA  1 
ATOM   140  C  C   . LEU A 1 19  ? -28.68628 8.34127  14.88550  1.000 11.19420 ? 19  LEU A C   1 
ATOM   141  O  O   . LEU A 1 19  ? -28.68154 7.76974  15.98147  1.000 11.97836 ? 19  LEU A O   1 
ATOM   142  C  CB  . LEU A 1 19  ? -31.06348 9.13059  14.76518  1.000 12.24835 ? 19  LEU A CB  1 
ATOM   143  C  CG  . LEU A 1 19  ? -30.73825 10.58618 15.12475  1.000 15.27142 ? 19  LEU A CG  1 
ATOM   144  C  CD1 . LEU A 1 19  ? -30.62409 11.44061 13.84977  1.000 11.92570 ? 19  LEU A CD1 1 
ATOM   145  C  CD2 . LEU A 1 19  ? -31.79217 11.14960 16.05786  1.000 16.49947 ? 19  LEU A CD2 1 
ATOM   146  N  N   . TYR A 1 20  ? -27.63336 8.96535  14.38561  1.000 12.04219 ? 20  TYR A N   1 
ATOM   147  C  CA  . TYR A 1 20  ? -26.42513 9.14648  15.16393  1.000 13.00342 ? 20  TYR A CA  1 
ATOM   148  C  C   . TYR A 1 20  ? -26.49961 10.49676 15.86527  1.000 16.25158 ? 20  TYR A C   1 
ATOM   149  O  O   . TYR A 1 20  ? -26.68408 11.53725 15.21748  1.000 12.56708 ? 20  TYR A O   1 
ATOM   150  C  CB  . TYR A 1 20  ? -25.17460 9.06049  14.29481  1.000 15.51809 ? 20  TYR A CB  1 
ATOM   151  C  CG  . TYR A 1 20  ? -23.94794 9.19723  15.15425  1.000 14.09605 ? 20  TYR A CG  1 
ATOM   152  C  CD1 . TYR A 1 20  ? -23.54768 8.15688  15.98067  1.000 14.67094 ? 20  TYR A CD1 1 
ATOM   153  C  CD2 . TYR A 1 20  ? -23.27218 10.41074 15.24842  1.000 13.03446 ? 20  TYR A CD2 1 
ATOM   154  C  CE1 . TYR A 1 20  ? -22.45414 8.28149  16.80439  1.000 18.37167 ? 20  TYR A CE1 1 
ATOM   155  C  CE2 . TYR A 1 20  ? -22.16725 10.55099 16.07624  1.000 18.11710 ? 20  TYR A CE2 1 
ATOM   156  C  CZ  . TYR A 1 20  ? -21.77174 9.47639  16.85982  1.000 18.39205 ? 20  TYR A CZ  1 
ATOM   157  O  OH  . TYR A 1 20  ? -20.69418 9.59691  17.68092  1.000 18.13356 ? 20  TYR A OH  1 
ATOM   158  N  N   . ILE A 1 21  ? -26.38937 10.46988 17.18556  1.000 13.79088 ? 21  ILE A N   1 
ATOM   159  C  CA  . ILE A 1 21  ? -26.39896 11.66254 18.02569  1.000 17.60616 ? 21  ILE A CA  1 
ATOM   160  C  C   . ILE A 1 21  ? -24.98926 11.84049 18.57061  1.000 18.72030 ? 21  ILE A C   1 
ATOM   161  O  O   . ILE A 1 21  ? -24.50172 10.96946 19.30429  1.000 17.25903 ? 21  ILE A O   1 
ATOM   162  C  CB  . ILE A 1 21  ? -27.42693 11.55350 19.16041  1.000 16.45248 ? 21  ILE A CB  1 
ATOM   163  C  CG1 . ILE A 1 21  ? -28.80121 11.27547 18.56891  1.000 17.00639 ? 21  ILE A CG1 1 
ATOM   164  C  CG2 . ILE A 1 21  ? -27.47078 12.85148 19.99802  1.000 16.48612 ? 21  ILE A CG2 1 
ATOM   165  C  CD1 . ILE A 1 21  ? -29.42508 10.00702 19.05812  1.000 23.37802 ? 21  ILE A CD1 1 
ATOM   166  N  N   . PRO A 1 22  ? -24.29299 12.91786 18.22141  1.000 18.08451 ? 22  PRO A N   1 
ATOM   167  C  CA  . PRO A 1 22  ? -22.89688 13.06003 18.63980  1.000 18.30412 ? 22  PRO A CA  1 
ATOM   168  C  C   . PRO A 1 22  ? -22.81658 13.30519 20.13948  1.000 20.57664 ? 22  PRO A C   1 
ATOM   169  O  O   . PRO A 1 22  ? -23.79564 13.66886 20.80044  1.000 19.80405 ? 22  PRO A O   1 
ATOM   170  C  CB  . PRO A 1 22  ? -22.41472 14.27018 17.83376  1.000 14.32000 ? 22  PRO A CB  1 
ATOM   171  C  CG  . PRO A 1 22  ? -23.65252 15.10025 17.68776  1.000 8.39378  ? 22  PRO A CG  1 
ATOM   172  C  CD  . PRO A 1 22  ? -24.78783 14.11984 17.52600  1.000 18.41804 ? 22  PRO A CD  1 
ATOM   173  N  N   . SER A 1 23  ? -21.62735 13.06190 20.68205  1.000 16.25707 ? 23  SER A N   1 
ATOM   174  C  CA  . SER A 1 23  ? -21.42769 13.24430 22.11364  1.000 17.56875 ? 23  SER A CA  1 
ATOM   175  C  C   . SER A 1 23  ? -21.59109 14.70392 22.51560  1.000 22.25377 ? 23  SER A C   1 
ATOM   176  O  O   . SER A 1 23  ? -21.98132 14.99553 23.65087  1.000 28.11675 ? 23  SER A O   1 
ATOM   177  C  CB  . SER A 1 23  ? -20.05079 12.72379 22.51545  1.000 24.60164 ? 23  SER A CB  1 
ATOM   178  O  OG  . SER A 1 23  ? -19.01785 13.49587 21.93535  1.000 26.32128 ? 23  SER A OG  1 
ATOM   179  N  N   . GLY A 1 24  ? -21.32516 15.62608 21.59941  1.000 22.61470 ? 24  GLY A N   1 
ATOM   180  C  CA  . GLY A 1 24  ? -21.47107 17.03653 21.87422  1.000 28.73899 ? 24  GLY A CA  1 
ATOM   181  C  C   . GLY A 1 24  ? -22.88947 17.54494 21.86566  1.000 28.67892 ? 24  GLY A C   1 
ATOM   182  O  O   . GLY A 1 24  ? -23.10967 18.73923 22.08851  1.000 31.99130 ? 24  GLY A O   1 
ATOM   183  N  N   . TYR A 1 25  ? -23.86995 16.67716 21.61657  1.000 31.37118 ? 25  TYR A N   1 
ATOM   184  C  CA  . TYR A 1 25  ? -25.26501 17.10189 21.61485  1.000 24.53037 ? 25  TYR A CA  1 
ATOM   185  C  C   . TYR A 1 25  ? -25.74370 17.30504 23.05006  1.000 36.99235 ? 25  TYR A C   1 
ATOM   186  O  O   . TYR A 1 25  ? -25.74992 16.36047 23.84315  1.000 29.97636 ? 25  TYR A O   1 
ATOM   187  C  CB  . TYR A 1 25  ? -26.16246 16.08765 20.90360  1.000 20.18002 ? 25  TYR A CB  1 
ATOM   188  C  CG  . TYR A 1 25  ? -27.59231 16.54951 20.94059  1.000 20.66482 ? 25  TYR A CG  1 
ATOM   189  C  CD1 . TYR A 1 25  ? -28.06030 17.46910 20.02039  1.000 18.84048 ? 25  TYR A CD1 1 
ATOM   190  C  CD2 . TYR A 1 25  ? -28.44693 16.14143 21.94950  1.000 26.73181 ? 25  TYR A CD2 1 
ATOM   191  C  CE1 . TYR A 1 25  ? -29.35678 17.93257 20.07197  1.000 23.56612 ? 25  TYR A CE1 1 
ATOM   192  C  CE2 . TYR A 1 25  ? -29.74576 16.60134 22.01679  1.000 31.26307 ? 25  TYR A CE2 1 
ATOM   193  C  CZ  . TYR A 1 25  ? -30.19447 17.50186 21.07179  1.000 24.08174 ? 25  TYR A CZ  1 
ATOM   194  O  OH  . TYR A 1 25  ? -31.47855 17.97115 21.12614  1.000 18.40479 ? 25  TYR A OH  1 
ATOM   195  N  N   . ASN A 1 26  ? -26.16573 18.53266 23.37672  1.000 35.74102 ? 26  ASN A N   1 
ATOM   196  C  CA  . ASN A 1 26  ? -26.76616 18.82665 24.67197  1.000 40.04887 ? 26  ASN A CA  1 
ATOM   197  C  C   . ASN A 1 26  ? -28.13522 19.48913 24.57263  1.000 36.38454 ? 26  ASN A C   1 
ATOM   198  O  O   . ASN A 1 26  ? -28.70292 19.84487 25.61160  1.000 53.09039 ? 26  ASN A O   1 
ATOM   199  C  CB  . ASN A 1 26  ? -25.84511 19.72799 25.51209  1.000 37.94081 ? 26  ASN A CB  1 
ATOM   200  C  CG  . ASN A 1 26  ? -25.42900 20.98075 24.77710  1.000 34.78957 ? 26  ASN A CG  1 
ATOM   201  O  OD1 . ASN A 1 26  ? -26.20598 21.55298 24.00929  1.000 45.73719 ? 26  ASN A OD1 1 
ATOM   202  N  ND2 . ASN A 1 26  ? -24.19704 21.41779 25.00505  1.000 50.62546 ? 26  ASN A ND2 1 
ATOM   203  N  N   . GLY A 1 27  ? -28.67904 19.67457 23.36816  1.000 35.68938 ? 27  GLY A N   1 
ATOM   204  C  CA  . GLY A 1 27  ? -29.98843 20.27860 23.20807  1.000 37.02402 ? 27  GLY A CA  1 
ATOM   205  C  C   . GLY A 1 27  ? -30.02454 21.78535 23.32749  1.000 41.70074 ? 27  GLY A C   1 
ATOM   206  O  O   . GLY A 1 27  ? -31.07830 22.38668 23.06596  1.000 33.25280 ? 27  GLY A O   1 
ATOM   207  N  N   . SER A 1 28  ? -28.91061 22.41541 23.71032  1.000 44.84510 ? 28  SER A N   1 
ATOM   208  C  CA  . SER A 1 28  ? -28.83113 23.86440 23.85782  1.000 47.51434 ? 28  SER A CA  1 
ATOM   209  C  C   . SER A 1 28  ? -28.56131 24.57187 22.54138  1.000 51.72246 ? 28  SER A C   1 
ATOM   210  O  O   . SER A 1 28  ? -28.75474 25.79063 22.44688  1.000 44.33326 ? 28  SER A O   1 
ATOM   211  C  CB  . SER A 1 28  ? -27.72126 24.22388 24.84630  1.000 55.39416 ? 28  SER A CB  1 
ATOM   212  O  OG  . SER A 1 28  ? -26.45465 24.18038 24.20279  1.000 64.03980 ? 28  SER A OG  1 
ATOM   213  N  N   . THR A 1 29  ? -28.10751 23.83036 21.53766  1.000 44.20982 ? 29  THR A N   1 
ATOM   214  C  CA  . THR A 1 29  ? -27.67174 24.37315 20.25835  1.000 39.08736 ? 29  THR A CA  1 
ATOM   215  C  C   . THR A 1 29  ? -28.31991 23.53320 19.16682  1.000 28.69173 ? 29  THR A C   1 
ATOM   216  O  O   . THR A 1 29  ? -28.15836 22.29819 19.16536  1.000 25.23865 ? 29  THR A O   1 
ATOM   217  C  CB  . THR A 1 29  ? -26.14150 24.33255 20.17635  1.000 44.36220 ? 29  THR A CB  1 
ATOM   218  O  OG1 . THR A 1 29  ? -25.57971 25.22109 21.15016  1.000 51.67685 ? 29  THR A OG1 1 
ATOM   219  C  CG2 . THR A 1 29  ? -25.63403 24.67036 18.79898  1.000 41.72812 ? 29  THR A CG2 1 
ATOM   220  N  N   . PRO A 1 30  ? -29.09671 24.11748 18.25898  1.000 36.95345 ? 30  PRO A N   1 
ATOM   221  C  CA  . PRO A 1 30  ? -29.61700 23.30943 17.14672  1.000 23.58249 ? 30  PRO A CA  1 
ATOM   222  C  C   . PRO A 1 30  ? -28.46502 22.85511 16.26410  1.000 25.83481 ? 30  PRO A C   1 
ATOM   223  O  O   . PRO A 1 30  ? -27.61472 23.65449 15.85961  1.000 21.82987 ? 30  PRO A O   1 
ATOM   224  C  CB  . PRO A 1 30  ? -30.58324 24.25389 16.41534  1.000 21.11980 ? 30  PRO A CB  1 
ATOM   225  C  CG  . PRO A 1 30  ? -30.24988 25.62801 16.89788  1.000 38.76397 ? 30  PRO A CG  1 
ATOM   226  C  CD  . PRO A 1 30  ? -29.60975 25.49837 18.25468  1.000 32.33265 ? 30  PRO A CD  1 
ATOM   227  N  N   . LEU A 1 31  ? -28.42772 21.57106 15.99851  1.000 19.73025 ? 31  LEU A N   1 
ATOM   228  C  CA  . LEU A 1 31  ? -27.36249 20.95545 15.23242  1.000 16.79781 ? 31  LEU A CA  1 
ATOM   229  C  C   . LEU A 1 31  ? -27.79657 20.73610 13.79482  1.000 11.57099 ? 31  LEU A C   1 
ATOM   230  O  O   . LEU A 1 31  ? -28.97983 20.50417 13.52604  1.000 13.11968 ? 31  LEU A O   1 
ATOM   231  C  CB  . LEU A 1 31  ? -26.98576 19.59913 15.83817  1.000 19.23027 ? 31  LEU A CB  1 
ATOM   232  C  CG  . LEU A 1 31  ? -26.39224 19.58574 17.24098  1.000 26.97410 ? 31  LEU A CG  1 
ATOM   233  C  CD1 . LEU A 1 31  ? -25.58956 18.30267 17.45463  1.000 21.31728 ? 31  LEU A CD1 1 
ATOM   234  C  CD2 . LEU A 1 31  ? -25.52843 20.81655 17.43729  1.000 25.40095 ? 31  LEU A CD2 1 
ATOM   235  N  N   . PRO A 1 32  ? -26.85847 20.75273 12.85079  1.000 12.70196 ? 32  PRO A N   1 
ATOM   236  C  CA  . PRO A 1 32  ? -27.18417 20.29061 11.49617  1.000 11.15852 ? 32  PRO A CA  1 
ATOM   237  C  C   . PRO A 1 32  ? -27.69597 18.85749 11.52281  1.000 15.18008 ? 32  PRO A C   1 
ATOM   238  O  O   . PRO A 1 32  ? -27.37981 18.07170 12.42391  1.000 11.17616 ? 32  PRO A O   1 
ATOM   239  C  CB  . PRO A 1 32  ? -25.84886 20.37446 10.75793  1.000 11.64654 ? 32  PRO A CB  1 
ATOM   240  C  CG  . PRO A 1 32  ? -25.03081 21.32370 11.54928  1.000 13.35210 ? 32  PRO A CG  1 
ATOM   241  C  CD  . PRO A 1 32  ? -25.44598 21.14219 12.97465  1.000 15.41531 ? 32  PRO A CD  1 
ATOM   242  N  N   . LEU A 1 33  ? -28.45782 18.50845 10.48423  1.000 9.75692  ? 33  LEU A N   1 
ATOM   243  C  CA  . LEU A 1 33  ? -28.93368 17.14677 10.27627  1.000 10.25716 ? 33  LEU A CA  1 
ATOM   244  C  C   . LEU A 1 33  ? -28.62616 16.74663 8.84289   1.000 13.61935 ? 33  LEU A C   1 
ATOM   245  O  O   . LEU A 1 33  ? -29.12042 17.38232 7.89945   1.000 10.13695 ? 33  LEU A O   1 
ATOM   246  C  CB  . LEU A 1 33  ? -30.44004 17.03593 10.54937  1.000 9.38481  ? 33  LEU A CB  1 
ATOM   247  C  CG  . LEU A 1 33  ? -31.09064 15.69727 10.16081  1.000 13.07685 ? 33  LEU A CG  1 
ATOM   248  C  CD1 . LEU A 1 33  ? -30.52558 14.50611 10.98553  1.000 9.84259  ? 33  LEU A CD1 1 
ATOM   249  C  CD2 . LEU A 1 33  ? -32.63147 15.78573 10.28166  1.000 14.05656 ? 33  LEU A CD2 1 
ATOM   250  N  N   . VAL A 1 34  ? -27.81876 15.69913 8.68041   1.000 10.81368 ? 34  VAL A N   1 
ATOM   251  C  CA  . VAL A 1 34  ? -27.52988 15.12028 7.37197   1.000 9.28190  ? 34  VAL A CA  1 
ATOM   252  C  C   . VAL A 1 34  ? -28.37514 13.86634 7.22856   1.000 12.17936 ? 34  VAL A C   1 
ATOM   253  O  O   . VAL A 1 34  ? -28.25573 12.93257 8.03128   1.000 12.63563 ? 34  VAL A O   1 
ATOM   254  C  CB  . VAL A 1 34  ? -26.03742 14.79326 7.20465   1.000 10.56771 ? 34  VAL A CB  1 
ATOM   255  C  CG1 . VAL A 1 34  ? -25.78693 14.16390 5.83786   1.000 10.08720 ? 34  VAL A CG1 1 
ATOM   256  C  CG2 . VAL A 1 34  ? -25.18730 16.04998 7.40596   1.000 8.97973  ? 34  VAL A CG2 1 
ATOM   257  N  N   . VAL A 1 35  ? -29.24397 13.84381 6.22502   1.000 8.15874  ? 35  VAL A N   1 
ATOM   258  C  CA  . VAL A 1 35  ? -30.02382 12.64731 5.93065   1.000 10.51345 ? 35  VAL A CA  1 
ATOM   259  C  C   . VAL A 1 35  ? -29.26294 11.84510 4.88906   1.000 11.00350 ? 35  VAL A C   1 
ATOM   260  O  O   . VAL A 1 35  ? -29.04964 12.32253 3.76641   1.000 11.52816 ? 35  VAL A O   1 
ATOM   261  C  CB  . VAL A 1 35  ? -31.42575 13.00162 5.42563   1.000 9.12688  ? 35  VAL A CB  1 
ATOM   262  C  CG1 . VAL A 1 35  ? -32.20144 11.71893 5.09716   1.000 12.76344 ? 35  VAL A CG1 1 
ATOM   263  C  CG2 . VAL A 1 35  ? -32.16060 13.86575 6.45055   1.000 7.82631  ? 35  VAL A CG2 1 
ATOM   264  N  N   . MET A 1 36  ? -28.86762 10.62448 5.25154   1.000 9.75835  ? 36  MET A N   1 
ATOM   265  C  CA  . MET A 1 36  ? -28.03635 9.80324  4.39178   1.000 11.17647 ? 36  MET A CA  1 
ATOM   266  C  C   . MET A 1 36  ? -28.91744 8.67762  3.83240   1.000 14.45616 ? 36  MET A C   1 
ATOM   267  O  O   . MET A 1 36  ? -29.46640 7.87738  4.60260   1.000 11.47560 ? 36  MET A O   1 
ATOM   268  C  CB  . MET A 1 36  ? -26.87645 9.19992  5.17625   1.000 11.55850 ? 36  MET A CB  1 
ATOM   269  C  CG  . MET A 1 36  ? -25.88201 10.30303 5.54057   1.000 12.28968 ? 36  MET A CG  1 
ATOM   270  S  SD  . MET A 1 36  ? -24.81855 10.79246 4.23780   1.000 13.09776 ? 36  MET A SD  1 
ATOM   271  C  CE  . MET A 1 36  ? -23.61768 9.37438  4.11843   1.000 11.77965 ? 36  MET A CE  1 
ATOM   272  N  N   . LEU A 1 37  ? -29.03642 8.60716  2.50412   1.000 11.50743 ? 37  LEU A N   1 
ATOM   273  C  CA  . LEU A 1 37  ? -29.94377 7.66735  1.84826   1.000 13.21240 ? 37  LEU A CA  1 
ATOM   274  C  C   . LEU A 1 37  ? -29.12545 6.54796  1.21286   1.000 13.07674 ? 37  LEU A C   1 
ATOM   275  O  O   . LEU A 1 37  ? -28.44540 6.76424  0.20199   1.000 10.58672 ? 37  LEU A O   1 
ATOM   276  C  CB  . LEU A 1 37  ? -30.80136 8.38526  0.80633   1.000 9.71923  ? 37  LEU A CB  1 
ATOM   277  C  CG  . LEU A 1 37  ? -31.65713 9.51291  1.38964   1.000 9.97777  ? 37  LEU A CG  1 
ATOM   278  C  CD1 . LEU A 1 37  ? -32.35511 10.27889 0.29108   1.000 7.07826  ? 37  LEU A CD1 1 
ATOM   279  C  CD2 . LEU A 1 37  ? -32.69682 8.95332  2.38802   1.000 11.95190 ? 37  LEU A CD2 1 
ATOM   280  N  N   . HIS A 1 38  ? -29.21450 5.35116  1.79037   1.000 11.19689 ? 38  HIS A N   1 
ATOM   281  C  CA  . HIS A 1 38  ? -28.38230 4.23248  1.36231   1.000 12.68153 ? 38  HIS A CA  1 
ATOM   282  C  C   . HIS A 1 38  ? -28.74308 3.78233  -0.05046  1.000 9.89885  ? 38  HIS A C   1 
ATOM   283  O  O   . HIS A 1 38  ? -29.82264 4.08309  -0.57174  1.000 12.30427 ? 38  HIS A O   1 
ATOM   284  C  CB  . HIS A 1 38  ? -28.52473 3.05946  2.32983   1.000 11.35278 ? 38  HIS A CB  1 
ATOM   285  C  CG  . HIS A 1 38  ? -29.87526 2.40569  2.29732   1.000 12.30784 ? 38  HIS A CG  1 
ATOM   286  N  ND1 . HIS A 1 38  ? -30.24708 1.50351  1.31747   1.000 10.76135 ? 38  HIS A ND1 1 
ATOM   287  C  CD2 . HIS A 1 38  ? -30.94096 2.52345  3.12437   1.000 12.63186 ? 38  HIS A CD2 1 
ATOM   288  C  CE1 . HIS A 1 38  ? -31.48369 1.09446  1.54675   1.000 13.71082 ? 38  HIS A CE1 1 
ATOM   289  N  NE2 . HIS A 1 38  ? -31.93340 1.70613  2.63015   1.000 11.66300 ? 38  HIS A NE2 1 
ATOM   290  N  N   . GLY A 1 39  ? -27.79714 3.07081  -0.68158  1.000 12.55259 ? 39  GLY A N   1 
ATOM   291  C  CA  . GLY A 1 39  ? -27.98055 2.56890  -2.02777  1.000 12.80464 ? 39  GLY A CA  1 
ATOM   292  C  C   . GLY A 1 39  ? -28.71530 1.23217  -2.03829  1.000 13.60772 ? 39  GLY A C   1 
ATOM   293  O  O   . GLY A 1 39  ? -29.05590 0.66469  -1.00000  1.000 12.30114 ? 39  GLY A O   1 
ATOM   294  N  N   . CYS A 1 40  ? -28.96247 0.72951  -3.24647  1.000 14.30325 ? 40  CYS A N   1 
ATOM   295  C  CA  . CYS A 1 40  ? -29.57570 -0.59313 -3.39149  1.000 15.66404 ? 40  CYS A CA  1 
ATOM   296  C  C   . CYS A 1 40  ? -28.79779 -1.64917 -2.60909  1.000 17.09181 ? 40  CYS A C   1 
ATOM   297  O  O   . CYS A 1 40  ? -27.56609 -1.63294 -2.57737  1.000 12.67256 ? 40  CYS A O   1 
ATOM   298  C  CB  . CYS A 1 40  ? -29.64572 -0.99430 -4.87407  1.000 16.30092 ? 40  CYS A CB  1 
ATOM   299  S  SG  . CYS A 1 40  ? -30.55068 0.16118  -5.93651  1.000 18.16345 ? 40  CYS A SG  1 
ATOM   300  N  N   . THR A 1 41  ? -29.54088 -2.59219 -2.01074  1.000 15.38981 ? 41  THR A N   1 
ATOM   301  C  CA  . THR A 1 41  ? -29.05280 -3.74056 -1.23718  1.000 17.43088 ? 41  THR A CA  1 
ATOM   302  C  C   . THR A 1 41  ? -28.48966 -3.34669 0.11713   1.000 14.60627 ? 41  THR A C   1 
ATOM   303  O  O   . THR A 1 41  ? -28.18986 -4.21798 0.94379   1.000 13.48012 ? 41  THR A O   1 
ATOM   304  C  CB  . THR A 1 41  ? -27.97631 -4.54316 -1.98670  1.000 17.03824 ? 41  THR A CB  1 
ATOM   305  O  OG1 . THR A 1 41  ? -26.68224 -3.93959 -1.79904  1.000 17.46897 ? 41  THR A OG1 1 
ATOM   306  C  CG2 . THR A 1 41  ? -28.30980 -4.64760 -3.47927  1.000 16.33159 ? 41  THR A CG2 1 
ATOM   307  N  N   . GLN A 1 42  ? -28.31666 -2.05423 0.35361   1.000 15.27534 ? 42  GLN A N   1 
ATOM   308  C  CA  . GLN A 1 42  ? -27.73257 -1.61412 1.60720   1.000 13.55777 ? 42  GLN A CA  1 
ATOM   309  C  C   . GLN A 1 42  ? -28.81380 -1.43225 2.66817   1.000 13.39236 ? 42  GLN A C   1 
ATOM   310  O  O   . GLN A 1 42  ? -30.00790 -1.59082 2.41409   1.000 16.08155 ? 42  GLN A O   1 
ATOM   311  C  CB  . GLN A 1 42  ? -26.95256 -0.31019 1.41102   1.000 13.37673 ? 42  GLN A CB  1 
ATOM   312  C  CG  . GLN A 1 42  ? -25.82269 -0.42964 0.43494   1.000 10.99056 ? 42  GLN A CG  1 
ATOM   313  C  CD  . GLN A 1 42  ? -24.96467 0.82007  0.38979   1.000 20.60609 ? 42  GLN A CD  1 
ATOM   314  O  OE1 . GLN A 1 42  ? -25.46885 1.93287  0.20819   1.000 16.34191 ? 42  GLN A OE1 1 
ATOM   315  N  NE2 . GLN A 1 42  ? -23.65813 0.64561  0.58479   1.000 18.84870 ? 42  GLN A NE2 1 
ATOM   316  N  N   . ASN A 1 43  ? -28.36670 -1.07409 3.86633   1.000 17.09683 ? 43  ASN A N   1 
ATOM   317  C  CA  . ASN A 1 43  ? -29.22170 -0.73702 4.99035   1.000 13.07913 ? 43  ASN A CA  1 
ATOM   318  C  C   . ASN A 1 43  ? -28.51765 0.35441  5.78415   1.000 13.18385 ? 43  ASN A C   1 
ATOM   319  O  O   . ASN A 1 43  ? -27.33651 0.64047  5.54864   1.000 11.09356 ? 43  ASN A O   1 
ATOM   320  C  CB  . ASN A 1 43  ? -29.48778 -1.95318 5.88469   1.000 13.44482 ? 43  ASN A CB  1 
ATOM   321  C  CG  . ASN A 1 43  ? -28.20916 -2.57486 6.38531   1.000 19.19800 ? 43  ASN A CG  1 
ATOM   322  O  OD1 . ASN A 1 43  ? -27.43680 -1.93465 7.08240   1.000 21.17963 ? 43  ASN A OD1 1 
ATOM   323  N  ND2 . ASN A 1 43  ? -27.98475 -3.84426 6.04448   1.000 31.73245 ? 43  ASN A ND2 1 
ATOM   324  N  N   . PRO A 1 44  ? -29.21169 0.96919  6.73988   1.000 12.85696 ? 44  PRO A N   1 
ATOM   325  C  CA  . PRO A 1 44  ? -28.58134 2.07366  7.50079   1.000 11.66440 ? 44  PRO A CA  1 
ATOM   326  C  C   . PRO A 1 44  ? -27.23153 1.74469  8.12884   1.000 13.44263 ? 44  PRO A C   1 
ATOM   327  O  O   . PRO A 1 44  ? -26.29802 2.54277  8.00414   1.000 11.37622 ? 44  PRO A O   1 
ATOM   328  C  CB  . PRO A 1 44  ? -29.64497 2.39626  8.54517   1.000 13.97942 ? 44  PRO A CB  1 
ATOM   329  C  CG  . PRO A 1 44  ? -30.91708 2.16229  7.78703   1.000 10.73727 ? 44  PRO A CG  1 
ATOM   330  C  CD  . PRO A 1 44  ? -30.67612 0.95598  6.90816   1.000 16.15962 ? 44  PRO A CD  1 
ATOM   331  N  N   . ASP A 1 45  ? -27.08749 0.58636  8.78007   1.000 12.94057 ? 45  ASP A N   1 
ATOM   332  C  CA  . ASP A 1 45  ? -25.81789 0.26387  9.43151   1.000 16.68642 ? 45  ASP A CA  1 
ATOM   333  C  C   . ASP A 1 45  ? -24.69024 0.12643  8.42290   1.000 12.32018 ? 45  ASP A C   1 
ATOM   334  O  O   . ASP A 1 45  ? -23.56267 0.56163  8.67752   1.000 13.61651 ? 45  ASP A O   1 
ATOM   335  C  CB  . ASP A 1 45  ? -25.94150 -1.02782 10.23555  1.000 14.27075 ? 45  ASP A CB  1 
ATOM   336  C  CG  . ASP A 1 45  ? -26.66343 -0.82709 11.52786  1.000 17.88694 ? 45  ASP A CG  1 
ATOM   337  O  OD1 . ASP A 1 45  ? -26.32746 0.13263  12.25548  1.000 17.86933 ? 45  ASP A OD1 1 
ATOM   338  O  OD2 . ASP A 1 45  ? -27.54246 -1.64259 11.83448  1.000 19.25706 ? 45  ASP A OD2 1 
ATOM   339  N  N   . ASP A 1 46  ? -24.96885 -0.53913 7.29781   1.000 11.18501 ? 46  ASP A N   1 
ATOM   340  C  CA  . ASP A 1 46  ? -23.96463 -0.73938 6.25623   1.000 9.92056  ? 46  ASP A CA  1 
ATOM   341  C  C   . ASP A 1 46  ? -23.53046 0.58601  5.63890   1.000 13.06870 ? 46  ASP A C   1 
ATOM   342  O  O   . ASP A 1 46  ? -22.33489 0.82067  5.39287   1.000 12.32923 ? 46  ASP A O   1 
ATOM   343  C  CB  . ASP A 1 46  ? -24.54483 -1.65237 5.18361   1.000 12.13439 ? 46  ASP A CB  1 
ATOM   344  C  CG  . ASP A 1 46  ? -23.52780 -2.00362 4.12586   1.000 17.47139 ? 46  ASP A CG  1 
ATOM   345  O  OD1 . ASP A 1 46  ? -22.34110 -2.16948 4.48990   1.000 19.77288 ? 46  ASP A OD1 1 
ATOM   346  O  OD2 . ASP A 1 46  ? -23.91137 -2.10429 2.93481   1.000 29.45372 ? 46  ASP A OD2 1 
ATOM   347  N  N   . PHE A 1 47  ? -24.49663 1.47161  5.38665   1.000 13.16783 ? 47  PHE A N   1 
ATOM   348  C  CA  . PHE A 1 47  ? -24.16907 2.76346  4.80201   1.000 12.29397 ? 47  PHE A CA  1 
ATOM   349  C  C   . PHE A 1 47  ? -23.38813 3.63543  5.77954   1.000 11.82970 ? 47  PHE A C   1 
ATOM   350  O  O   . PHE A 1 47  ? -22.41787 4.30031  5.39704   1.000 12.32066 ? 47  PHE A O   1 
ATOM   351  C  CB  . PHE A 1 47  ? -25.45435 3.45064  4.36336   1.000 10.57370 ? 47  PHE A CB  1 
ATOM   352  C  CG  . PHE A 1 47  ? -25.23843 4.49392  3.30620   1.000 13.37703 ? 47  PHE A CG  1 
ATOM   353  C  CD1 . PHE A 1 47  ? -24.35968 4.26436  2.25467   1.000 10.68090 ? 47  PHE A CD1 1 
ATOM   354  C  CD2 . PHE A 1 47  ? -25.90393 5.70632  3.37251   1.000 14.23121 ? 47  PHE A CD2 1 
ATOM   355  C  CE1 . PHE A 1 47  ? -24.17116 5.23947  1.27371   1.000 11.66182 ? 47  PHE A CE1 1 
ATOM   356  C  CE2 . PHE A 1 47  ? -25.72622 6.68006  2.39459   1.000 10.90988 ? 47  PHE A CE2 1 
ATOM   357  C  CZ  . PHE A 1 47  ? -24.85559 6.44360  1.35004   1.000 11.80615 ? 47  PHE A CZ  1 
ATOM   358  N  N   . ALA A 1 48  ? -23.77635 3.62039  7.05330   1.000 14.65008 ? 48  ALA A N   1 
ATOM   359  C  CA  . ALA A 1 48  ? -22.98890 4.31411  8.06454   1.000 10.90304 ? 48  ALA A CA  1 
ATOM   360  C  C   . ALA A 1 48  ? -21.57709 3.76311  8.12113   1.000 16.86951 ? 48  ALA A C   1 
ATOM   361  O  O   . ALA A 1 48  ? -20.60184 4.52429  8.13740   1.000 12.13746 ? 48  ALA A O   1 
ATOM   362  C  CB  . ALA A 1 48  ? -23.65936 4.18612  9.43115   1.000 12.72877 ? 48  ALA A CB  1 
ATOM   363  N  N   . ALA A 1 49  ? -21.45133 2.43001  8.16411   1.000 16.30288 ? 49  ALA A N   1 
ATOM   364  C  CA  . ALA A 1 49  ? -20.14113 1.80244  8.30026   1.000 15.64475 ? 49  ALA A CA  1 
ATOM   365  C  C   . ALA A 1 49  ? -19.21831 2.16533  7.14403   1.000 12.01397 ? 49  ALA A C   1 
ATOM   366  O  O   . ALA A 1 49  ? -18.03136 2.44048  7.35136   1.000 14.26358 ? 49  ALA A O   1 
ATOM   367  C  CB  . ALA A 1 49  ? -20.30311 0.28229  8.39974   1.000 14.83268 ? 49  ALA A CB  1 
ATOM   368  N  N   . GLY A 1 50  ? -19.73370 2.15563  5.92057   1.000 11.57825 ? 50  GLY A N   1 
ATOM   369  C  CA  . GLY A 1 50  ? -18.91358 2.47544  4.77471   1.000 10.06563 ? 50  GLY A CA  1 
ATOM   370  C  C   . GLY A 1 50  ? -18.62383 3.95986  4.59757   1.000 10.05391 ? 50  GLY A C   1 
ATOM   371  O  O   . GLY A 1 50  ? -17.47550 4.33311  4.32503   1.000 11.39285 ? 50  GLY A O   1 
ATOM   372  N  N   . THR A 1 51  ? -19.64698 4.81405  4.73208   1.000 9.89722  ? 51  THR A N   1 
ATOM   373  C  CA  . THR A 1 51  ? -19.41907 6.24103  4.55450   1.000 9.61171  ? 51  THR A CA  1 
ATOM   374  C  C   . THR A 1 51  ? -18.63039 6.84794  5.70474   1.000 15.86823 ? 51  THR A C   1 
ATOM   375  O  O   . THR A 1 51  ? -18.03218 7.91600  5.53630   1.000 12.74629 ? 51  THR A O   1 
ATOM   376  C  CB  . THR A 1 51  ? -20.73893 7.00813  4.40675   1.000 12.07518 ? 51  THR A CB  1 
ATOM   377  O  OG1 . THR A 1 51  ? -21.50751 6.91734  5.61572   1.000 11.42571 ? 51  THR A OG1 1 
ATOM   378  C  CG2 . THR A 1 51  ? -21.55937 6.49042  3.22106   1.000 10.90903 ? 51  THR A CG2 1 
ATOM   379  N  N   . GLU A 1 52  ? -18.65135 6.21909  6.87519   1.000 13.63159 ? 52  GLU A N   1 
ATOM   380  C  CA  . GLU A 1 52  ? -18.06223 6.77983  8.08311   1.000 11.50613 ? 52  GLU A CA  1 
ATOM   381  C  C   . GLU A 1 52  ? -18.74221 8.07477  8.49861   1.000 11.81010 ? 52  GLU A C   1 
ATOM   382  O  O   . GLU A 1 52  ? -18.17225 8.85033  9.26030   1.000 14.72310 ? 52  GLU A O   1 
ATOM   383  C  CB  . GLU A 1 52  ? -16.55294 6.99635  7.91706   1.000 16.78370 ? 52  GLU A CB  1 
ATOM   384  C  CG  . GLU A 1 52  ? -15.80528 5.73268  7.51552   1.000 14.08379 ? 52  GLU A CG  1 
ATOM   385  C  CD  . GLU A 1 52  ? -14.31143 5.97838  7.22282   1.000 22.08487 ? 52  GLU A CD  1 
ATOM   386  O  OE1 . GLU A 1 52  ? -13.95731 6.89479  6.43495   1.000 21.06575 ? 52  GLU A OE1 1 
ATOM   387  O  OE2 . GLU A 1 52  ? -13.48392 5.24953  7.78681   1.000 20.42164 ? 52  GLU A OE2 1 
ATOM   388  N  N   . MET A 1 53  ? -19.98458 8.31158  8.05222   1.000 13.55702 ? 53  MET A N   1 
ATOM   389  C  CA  . MET A 1 53  ? -20.59101 9.61783  8.30240   1.000 12.58521 ? 53  MET A CA  1 
ATOM   390  C  C   . MET A 1 53  ? -20.77488 9.84444  9.80645   1.000 16.06868 ? 53  MET A C   1 
ATOM   391  O  O   . MET A 1 53  ? -20.77269 10.98984 10.26247  1.000 17.95798 ? 53  MET A O   1 
ATOM   392  C  CB  . MET A 1 53  ? -21.94735 9.72997  7.60504   1.000 14.22427 ? 53  MET A CB  1 
ATOM   393  C  CG  . MET A 1 53  ? -22.46545 11.16692 7.33878   1.000 19.87345 ? 53  MET A CG  1 
ATOM   394  S  SD  . MET A 1 53  ? -21.17925 12.40820 6.95096   1.000 15.85166 ? 53  MET A SD  1 
ATOM   395  C  CE  . MET A 1 53  ? -20.91010 12.08686 5.25110   1.000 15.15399 ? 53  MET A CE  1 
ATOM   396  N  N   . ASN A 1 54  ? -20.90228 8.77615  10.60281  1.000 14.23289 ? 54  ASN A N   1 
ATOM   397  C  CA  . ASN A 1 54  ? -21.02425 8.98193  12.04614  1.000 12.58684 ? 54  ASN A CA  1 
ATOM   398  C  C   . ASN A 1 54  ? -19.72340 9.46293  12.66367  1.000 15.24859 ? 54  ASN A C   1 
ATOM   399  O  O   . ASN A 1 54  ? -19.74404 10.09624 13.72371  1.000 18.19632 ? 54  ASN A O   1 
ATOM   400  C  CB  . ASN A 1 54  ? -21.48386 7.71251  12.77200  1.000 14.48224 ? 54  ASN A CB  1 
ATOM   401  C  CG  . ASN A 1 54  ? -22.87479 7.26619  12.35794  1.000 15.65426 ? 54  ASN A CG  1 
ATOM   402  O  OD1 . ASN A 1 54  ? -23.57373 7.96848  11.62340  1.000 15.22154 ? 54  ASN A OD1 1 
ATOM   403  N  ND2 . ASN A 1 54  ? -23.30245 6.11501  12.86906  1.000 13.36765 ? 54  ASN A ND2 1 
ATOM   404  N  N   . VAL A 1 55  ? -18.59234 9.17461  12.03181  1.000 15.77900 ? 55  VAL A N   1 
ATOM   405  C  CA  . VAL A 1 55  ? -17.34571 9.70678  12.54037  1.000 15.50668 ? 55  VAL A CA  1 
ATOM   406  C  C   . VAL A 1 55  ? -17.27571 11.19167 12.25127  1.000 18.47095 ? 55  VAL A C   1 
ATOM   407  O  O   . VAL A 1 55  ? -16.89673 11.99054 13.11161  1.000 17.24241 ? 55  VAL A O   1 
ATOM   408  C  CB  . VAL A 1 55  ? -16.15838 8.94531  11.92921  1.000 17.93595 ? 55  VAL A CB  1 
ATOM   409  C  CG1 . VAL A 1 55  ? -14.83897 9.54122  12.41898  1.000 20.90628 ? 55  VAL A CG1 1 
ATOM   410  C  CG2 . VAL A 1 55  ? -16.25799 7.46269  12.26755  1.000 17.90802 ? 55  VAL A CG2 1 
ATOM   411  N  N   . TYR A 1 56  ? -17.66812 11.59016 11.04237  1.000 15.57842 ? 56  TYR A N   1 
ATOM   412  C  CA  . TYR A 1 56  ? -17.69713 13.01507 10.72539  1.000 17.20844 ? 56  TYR A CA  1 
ATOM   413  C  C   . TYR A 1 56  ? -18.71989 13.74062 11.58892  1.000 15.12269 ? 56  TYR A C   1 
ATOM   414  O  O   . TYR A 1 56  ? -18.45949 14.84249 12.08372  1.000 15.64843 ? 56  TYR A O   1 
ATOM   415  C  CB  . TYR A 1 56  ? -17.98178 13.20239 9.23048   1.000 14.22983 ? 56  TYR A CB  1 
ATOM   416  C  CG  . TYR A 1 56  ? -16.81871 12.75223 8.38207   1.000 15.01177 ? 56  TYR A CG  1 
ATOM   417  C  CD1 . TYR A 1 56  ? -15.72671 13.58872 8.18212   1.000 22.98499 ? 56  TYR A CD1 1 
ATOM   418  C  CD2 . TYR A 1 56  ? -16.78402 11.47500 7.81913   1.000 13.99197 ? 56  TYR A CD2 1 
ATOM   419  C  CE1 . TYR A 1 56  ? -14.64522 13.18615 7.42766   1.000 27.53924 ? 56  TYR A CE1 1 
ATOM   420  C  CE2 . TYR A 1 56  ? -15.69420 11.05829 7.05988   1.000 19.15003 ? 56  TYR A CE2 1 
ATOM   421  C  CZ  . TYR A 1 56  ? -14.63633 11.92212 6.86237   1.000 30.44417 ? 56  TYR A CZ  1 
ATOM   422  O  OH  . TYR A 1 56  ? -13.55184 11.53547 6.10920   1.000 32.74485 ? 56  TYR A OH  1 
ATOM   423  N  N   . ALA A 1 57  ? -19.88092 13.12813 11.79606  1.000 13.80944 ? 57  ALA A N   1 
ATOM   424  C  CA  . ALA A 1 57  ? -20.88694 13.70693 12.67340  1.000 13.47609 ? 57  ALA A CA  1 
ATOM   425  C  C   . ALA A 1 57  ? -20.34786 13.88522 14.08412  1.000 13.97030 ? 57  ALA A C   1 
ATOM   426  O  O   . ALA A 1 57  ? -20.61629 14.89802 14.73770  1.000 14.79721 ? 57  ALA A O   1 
ATOM   427  C  CB  . ALA A 1 57  ? -22.12668 12.82081 12.69297  1.000 15.88392 ? 57  ALA A CB  1 
ATOM   428  N  N   . GLU A 1 58  ? -19.61242 12.89541 14.58238  1.000 12.38224 ? 58  GLU A N   1 
ATOM   429  C  CA  . GLU A 1 58  ? -18.99369 13.03636 15.89372  1.000 14.16364 ? 58  GLU A CA  1 
ATOM   430  C  C   . GLU A 1 58  ? -17.99216 14.18085 15.90050  1.000 18.47616 ? 58  GLU A C   1 
ATOM   431  O  O   . GLU A 1 58  ? -17.95106 14.98547 16.84338  1.000 18.60769 ? 58  GLU A O   1 
ATOM   432  C  CB  . GLU A 1 58  ? -18.29811 11.72744 16.27136  1.000 18.02099 ? 58  GLU A CB  1 
ATOM   433  C  CG  . GLU A 1 58  ? -17.60351 11.76313 17.62374  1.000 19.89115 ? 58  GLU A CG  1 
ATOM   434  C  CD  . GLU A 1 58  ? -18.57531 12.02523 18.75685  1.000 18.32674 ? 58  GLU A CD  1 
ATOM   435  O  OE1 . GLU A 1 58  ? -19.76277 11.67271 18.61597  1.000 19.73502 ? 58  GLU A OE1 1 
ATOM   436  O  OE2 . GLU A 1 58  ? -18.16998 12.60616 19.78630  1.000 21.58833 ? 58  GLU A OE2 1 
ATOM   437  N  N   . GLN A 1 59  ? -17.17097 14.25953 14.85553  1.000 14.75149 ? 59  GLN A N   1 
ATOM   438  C  CA  A GLN A 1 59  ? -16.11075 15.25730 14.80046  0.575 13.58326 ? 59  GLN A CA  1 
ATOM   439  C  CA  B GLN A 1 59  ? -16.10696 15.25509 14.82394  0.425 13.63268 ? 59  GLN A CA  1 
ATOM   440  C  C   . GLN A 1 59  ? -16.65008 16.66227 14.58513  1.000 15.68602 ? 59  GLN A C   1 
ATOM   441  O  O   . GLN A 1 59  ? -16.03741 17.63733 15.02992  1.000 14.84193 ? 59  GLN A O   1 
ATOM   442  C  CB  A GLN A 1 59  ? -15.12977 14.90589 13.69042  0.575 18.37972 ? 59  GLN A CB  1 
ATOM   443  C  CB  B GLN A 1 59  ? -15.06853 14.87869 13.75834  0.425 18.39754 ? 59  GLN A CB  1 
ATOM   444  C  CG  A GLN A 1 59  ? -14.48014 13.56842 13.89317  0.575 15.40952 ? 59  GLN A CG  1 
ATOM   445  C  CG  B GLN A 1 59  ? -14.47029 16.05484 12.97831  0.425 22.87741 ? 59  GLN A CG  1 
ATOM   446  C  CD  A GLN A 1 59  ? -13.39536 13.66435 14.92102  0.575 16.86808 ? 59  GLN A CD  1 
ATOM   447  C  CD  B GLN A 1 59  ? -13.70568 15.63532 11.71625  0.425 19.94821 ? 59  GLN A CD  1 
ATOM   448  O  OE1 A GLN A 1 59  ? -12.40406 14.35964 14.72269  0.575 20.24113 ? 59  GLN A OE1 1 
ATOM   449  O  OE1 B GLN A 1 59  ? -14.22119 15.73247 10.60096  0.425 17.13906 ? 59  GLN A OE1 1 
ATOM   450  N  NE2 A GLN A 1 59  ? -13.58995 12.98942 16.04613  0.575 10.85506 ? 59  GLN A NE2 1 
ATOM   451  N  NE2 B GLN A 1 59  ? -12.46546 15.19690 11.89169  0.425 13.82577 ? 59  GLN A NE2 1 
ATOM   452  N  N   . ASN A 1 60  ? -17.78816 16.79170 13.90701  1.000 16.32370 ? 60  ASN A N   1 
ATOM   453  C  CA  . ASN A 1 60  ? -18.31785 18.09225 13.52924  1.000 18.03219 ? 60  ASN A CA  1 
ATOM   454  C  C   . ASN A 1 60  ? -19.57584 18.46960 14.28689  1.000 18.93580 ? 60  ASN A C   1 
ATOM   455  O  O   . ASN A 1 60  ? -20.17348 19.51932 14.00186  1.000 16.14534 ? 60  ASN A O   1 
ATOM   456  C  CB  . ASN A 1 60  ? -18.58212 18.11043 12.02431  1.000 13.94683 ? 60  ASN A CB  1 
ATOM   457  C  CG  . ASN A 1 60  ? -17.30776 18.09811 11.24218  1.000 16.24892 ? 60  ASN A CG  1 
ATOM   458  O  OD1 . ASN A 1 60  ? -16.68930 19.14312 11.01857  1.000 16.72649 ? 60  ASN A OD1 1 
ATOM   459  N  ND2 . ASN A 1 60  ? -16.86826 16.91638 10.86466  1.000 16.08766 ? 60  ASN A ND2 1 
ATOM   460  N  N   . ASN A 1 61  ? -19.99425 17.64097 15.23751  1.000 17.15681 ? 61  ASN A N   1 
ATOM   461  C  CA  . ASN A 1 61  ? -21.16053 17.90953 16.05859  1.000 14.77947 ? 61  ASN A CA  1 
ATOM   462  C  C   . ASN A 1 61  ? -22.41172 18.08867 15.19687  1.000 17.37121 ? 61  ASN A C   1 
ATOM   463  O  O   . ASN A 1 61  ? -23.09200 19.11110 15.25398  1.000 16.59622 ? 61  ASN A O   1 
ATOM   464  C  CB  . ASN A 1 61  ? -20.92886 19.13022 16.96182  1.000 15.39746 ? 61  ASN A CB  1 
ATOM   465  C  CG  . ASN A 1 61  ? -21.77060 19.08958 18.22154  1.000 26.28614 ? 61  ASN A CG  1 
ATOM   466  O  OD1 . ASN A 1 61  ? -22.25842 18.02705 18.62019  1.000 25.98941 ? 61  ASN A OD1 1 
ATOM   467  N  ND2 . ASN A 1 61  ? -21.96387 20.24971 18.84908  1.000 27.18956 ? 61  ASN A ND2 1 
ATOM   468  N  N   . PHE A 1 62  ? -22.73628 17.06123 14.40993  1.000 11.32945 ? 62  PHE A N   1 
ATOM   469  C  CA  . PHE A 1 62  ? -24.01429 17.07622 13.71500  1.000 14.29918 ? 62  PHE A CA  1 
ATOM   470  C  C   . PHE A 1 62  ? -24.71528 15.72934 13.83146  1.000 14.10099 ? 62  PHE A C   1 
ATOM   471  O  O   . PHE A 1 62  ? -24.12638 14.71402 14.22302  1.000 14.01112 ? 62  PHE A O   1 
ATOM   472  C  CB  . PHE A 1 62  ? -23.89438 17.51640 12.22269  1.000 12.73406 ? 62  PHE A CB  1 
ATOM   473  C  CG  . PHE A 1 62  ? -23.02769 16.63139 11.33128  1.000 12.07774 ? 62  PHE A CG  1 
ATOM   474  C  CD1 . PHE A 1 62  ? -23.54814 15.47641 10.74905  1.000 11.04155 ? 62  PHE A CD1 1 
ATOM   475  C  CD2 . PHE A 1 62  ? -21.74491 17.02917 10.96781  1.000 10.46051 ? 62  PHE A CD2 1 
ATOM   476  C  CE1 . PHE A 1 62  ? -22.77701 14.70549 9.88057   1.000 9.55521  ? 62  PHE A CE1 1 
ATOM   477  C  CE2 . PHE A 1 62  ? -20.97155 16.25241 10.10881  1.000 16.23942 ? 62  PHE A CE2 1 
ATOM   478  C  CZ  . PHE A 1 62  ? -21.49203 15.08939 9.56650   1.000 16.24676 ? 62  PHE A CZ  1 
ATOM   479  N  N   . LEU A 1 63  ? -26.01256 15.76266 13.53854  1.000 10.76193 ? 63  LEU A N   1 
ATOM   480  C  CA  . LEU A 1 63  ? -26.87451 14.59239 13.56496  1.000 11.42268 ? 63  LEU A CA  1 
ATOM   481  C  C   . LEU A 1 63  ? -26.91271 13.96059 12.18214  1.000 12.80741 ? 63  LEU A C   1 
ATOM   482  O  O   . LEU A 1 63  ? -26.87535 14.66214 11.16972  1.000 12.06564 ? 63  LEU A O   1 
ATOM   483  C  CB  . LEU A 1 63  ? -28.29273 14.98976 13.97810  1.000 10.49730 ? 63  LEU A CB  1 
ATOM   484  C  CG  . LEU A 1 63  ? -28.49924 15.65986 15.33854  1.000 17.68832 ? 63  LEU A CG  1 
ATOM   485  C  CD1 . LEU A 1 63  ? -29.75161 16.55200 15.29819  1.000 16.29533 ? 63  LEU A CD1 1 
ATOM   486  C  CD2 . LEU A 1 63  ? -28.62537 14.57554 16.40781  1.000 14.08841 ? 63  LEU A CD2 1 
ATOM   487  N  N   . VAL A 1 64  ? -27.00532 12.62941 12.14412  1.000 10.98000 ? 64  VAL A N   1 
ATOM   488  C  CA  . VAL A 1 64  ? -27.10140 11.88681 10.88948  1.000 8.85212  ? 64  VAL A CA  1 
ATOM   489  C  C   . VAL A 1 64  ? -28.26969 10.92592 10.98965  1.000 12.98819 ? 64  VAL A C   1 
ATOM   490  O  O   . VAL A 1 64  ? -28.29676 10.06495 11.87835  1.000 12.96792 ? 64  VAL A O   1 
ATOM   491  C  CB  . VAL A 1 64  ? -25.82329 11.09973 10.56431  1.000 17.10208 ? 64  VAL A CB  1 
ATOM   492  C  CG1 . VAL A 1 64  ? -25.81487 10.71789 9.08386   1.000 8.61292  ? 64  VAL A CG1 1 
ATOM   493  C  CG2 . VAL A 1 64  ? -24.60907 11.89619 10.93159  1.000 14.48133 ? 64  VAL A CG2 1 
ATOM   494  N  N   . ALA A 1 65  ? -29.20088 11.02863 10.05214  1.000 9.89535  ? 65  ALA A N   1 
ATOM   495  C  CA  . ALA A 1 65  ? -30.33642 10.11606 9.98730   1.000 9.80228  ? 65  ALA A CA  1 
ATOM   496  C  C   . ALA A 1 65  ? -30.18764 9.25100  8.75316   1.000 12.90575 ? 65  ALA A C   1 
ATOM   497  O  O   . ALA A 1 65  ? -29.84978 9.74668  7.67425   1.000 13.80786 ? 65  ALA A O   1 
ATOM   498  C  CB  . ALA A 1 65  ? -31.67082 10.86203 9.94624   1.000 10.78736 ? 65  ALA A CB  1 
ATOM   499  N  N   . TYR A 1 66  ? -30.43941 7.95424  8.91918   1.000 9.93803  ? 66  TYR A N   1 
ATOM   500  C  CA  . TYR A 1 66  ? -30.36959 6.97929  7.83432   1.000 11.95595 ? 66  TYR A CA  1 
ATOM   501  C  C   . TYR A 1 66  ? -31.74712 6.35272  7.67095   1.000 13.52142 ? 66  TYR A C   1 
ATOM   502  O  O   . TYR A 1 66  ? -32.06257 5.35692  8.34477   1.000 14.01018 ? 66  TYR A O   1 
ATOM   503  C  CB  . TYR A 1 66  ? -29.33165 5.89631  8.13027   1.000 10.95693 ? 66  TYR A CB  1 
ATOM   504  C  CG  . TYR A 1 66  ? -27.90829 6.36527  8.35026   1.000 13.46587 ? 66  TYR A CG  1 
ATOM   505  C  CD1 . TYR A 1 66  ? -27.49238 6.83913  9.59119   1.000 13.44395 ? 66  TYR A CD1 1 
ATOM   506  C  CD2 . TYR A 1 66  ? -26.96637 6.29351  7.32650   1.000 12.08413 ? 66  TYR A CD2 1 
ATOM   507  C  CE1 . TYR A 1 66  ? -26.19552 7.23992  9.80321   1.000 11.61442 ? 66  TYR A CE1 1 
ATOM   508  C  CE2 . TYR A 1 66  ? -25.66269 6.70251  7.53010   1.000 9.13454  ? 66  TYR A CE2 1 
ATOM   509  C  CZ  . TYR A 1 66  ? -25.28613 7.17370  8.77258   1.000 11.94592 ? 66  TYR A CZ  1 
ATOM   510  O  OH  . TYR A 1 66  ? -23.99612 7.56430  9.00023   1.000 9.80773  ? 66  TYR A OH  1 
ATOM   511  N  N   . PRO A 1 67  ? -32.60580 6.90323  6.81988   1.000 15.82943 ? 67  PRO A N   1 
ATOM   512  C  CA  . PRO A 1 67  ? -33.86629 6.21672  6.53090   1.000 11.69163 ? 67  PRO A CA  1 
ATOM   513  C  C   . PRO A 1 67  ? -33.58762 4.87613  5.87119   1.000 11.87052 ? 67  PRO A C   1 
ATOM   514  O  O   . PRO A 1 67  ? -32.66862 4.73515  5.06572   1.000 11.12704 ? 67  PRO A O   1 
ATOM   515  C  CB  . PRO A 1 67  ? -34.59089 7.17832  5.58896   1.000 11.57595 ? 67  PRO A CB  1 
ATOM   516  C  CG  . PRO A 1 67  ? -33.96393 8.52842  5.86125   1.000 6.97306  ? 67  PRO A CG  1 
ATOM   517  C  CD  . PRO A 1 67  ? -32.52576 8.21803  6.16115   1.000 12.15112 ? 67  PRO A CD  1 
ATOM   518  N  N   . GLU A 1 68  ? -34.37034 3.87672  6.24434   1.000 14.65688 ? 68  GLU A N   1 
ATOM   519  C  CA  . GLU A 1 68  ? -34.18727 2.53313  5.72307   1.000 11.21526 ? 68  GLU A CA  1 
ATOM   520  C  C   . GLU A 1 68  ? -35.22254 2.27072  4.63449   1.000 14.40497 ? 68  GLU A C   1 
ATOM   521  O  O   . GLU A 1 68  ? -36.41645 2.51152  4.83270   1.000 14.32927 ? 68  GLU A O   1 
ATOM   522  C  CB  . GLU A 1 68  ? -34.32055 1.49866  6.84215   1.000 13.69243 ? 68  GLU A CB  1 
ATOM   523  C  CG  . GLU A 1 68  ? -34.34553 0.07300  6.35942   1.000 15.09212 ? 68  GLU A CG  1 
ATOM   524  C  CD  . GLU A 1 68  ? -34.38826 -0.91919 7.51639   1.000 27.58108 ? 68  GLU A CD  1 
ATOM   525  O  OE1 . GLU A 1 68  ? -33.36119 -1.08360 8.20575   1.000 24.17965 ? 68  GLU A OE1 1 
ATOM   526  O  OE2 . GLU A 1 68  ? -35.46565 -1.51608 7.73464   1.000 30.22965 ? 68  GLU A OE2 1 
ATOM   527  N  N   . GLN A 1 69  ? -34.75981 1.79237  3.48252   1.000 14.75446 ? 69  GLN A N   1 
ATOM   528  C  CA  . GLN A 1 69  ? -35.66603 1.29785  2.46493   1.000 9.36159  ? 69  GLN A CA  1 
ATOM   529  C  C   . GLN A 1 69  ? -35.76035 -0.20782 2.61660   1.000 13.63631 ? 69  GLN A C   1 
ATOM   530  O  O   . GLN A 1 69  ? -34.77324 -0.91604 2.33038   1.000 14.88096 ? 69  GLN A O   1 
ATOM   531  C  CB  . GLN A 1 69  ? -35.18488 1.66465  1.06226   1.000 10.71113 ? 69  GLN A CB  1 
ATOM   532  C  CG  . GLN A 1 69  ? -36.07294 1.09585  -0.05489  1.000 13.04986 ? 69  GLN A CG  1 
ATOM   533  C  CD  . GLN A 1 69  ? -37.36316 1.88931  -0.27539  1.000 10.81966 ? 69  GLN A CD  1 
ATOM   534  O  OE1 . GLN A 1 69  ? -38.04139 2.30968  0.67457   1.000 12.85542 ? 69  GLN A OE1 1 
ATOM   535  N  NE2 . GLN A 1 69  ? -37.70633 2.09166  -1.53109  1.000 10.21342 ? 69  GLN A NE2 1 
ATOM   536  N  N   . PRO A 1 70  ? -36.89019 -0.74462 3.06010   1.000 17.17164 ? 70  PRO A N   1 
ATOM   537  C  CA  . PRO A 1 70  ? -36.97444 -2.18680 3.30064   1.000 16.57037 ? 70  PRO A CA  1 
ATOM   538  C  C   . PRO A 1 70  ? -37.24059 -2.95068 2.01055   1.000 17.50644 ? 70  PRO A C   1 
ATOM   539  O  O   . PRO A 1 70  ? -37.69475 -2.40401 1.00255   1.000 13.54139 ? 70  PRO A O   1 
ATOM   540  C  CB  . PRO A 1 70  ? -38.16100 -2.30241 4.26362   1.000 14.46608 ? 70  PRO A CB  1 
ATOM   541  C  CG  . PRO A 1 70  ? -39.08576 -1.21396 3.78883   1.000 16.76094 ? 70  PRO A CG  1 
ATOM   542  C  CD  . PRO A 1 70  ? -38.16395 -0.05465 3.37914   1.000 10.95501 ? 70  PRO A CD  1 
ATOM   543  N  N   A SER A 1 71  ? -36.94780 -4.25023 2.05590   0.621 18.66261 ? 71  SER A N   1 
ATOM   544  N  N   B SER A 1 71  ? -36.96791 -4.25432 2.07110   0.379 18.68917 ? 71  SER A N   1 
ATOM   545  C  CA  A SER A 1 71  ? -37.20620 -5.08962 0.88915   0.621 18.71998 ? 71  SER A CA  1 
ATOM   546  C  CA  B SER A 1 71  ? -37.21442 -5.10968 0.91475   0.379 18.82616 ? 71  SER A CA  1 
ATOM   547  C  C   A SER A 1 71  ? -38.68307 -5.11323 0.50452   0.621 19.97826 ? 71  SER A C   1 
ATOM   548  C  C   B SER A 1 71  ? -38.68149 -5.09275 0.50221   0.379 20.00996 ? 71  SER A C   1 
ATOM   549  O  O   A SER A 1 71  ? -39.00396 -5.37976 -0.66024  0.621 22.81631 ? 71  SER A O   1 
ATOM   550  O  O   B SER A 1 71  ? -38.99849 -5.31509 -0.67285  0.379 22.74791 ? 71  SER A O   1 
ATOM   551  C  CB  A SER A 1 71  ? -36.70416 -6.51300 1.14935   0.621 25.43341 ? 71  SER A CB  1 
ATOM   552  C  CB  B SER A 1 71  ? -36.76441 -6.53540 1.22674   0.379 25.44929 ? 71  SER A CB  1 
ATOM   553  O  OG  A SER A 1 71  ? -37.32319 -7.05821 2.29880   0.621 24.78947 ? 71  SER A OG  1 
ATOM   554  O  OG  B SER A 1 71  ? -35.37151 -6.56277 1.45335   0.379 21.44315 ? 71  SER A OG  1 
ATOM   555  N  N   . SER A 1 72  ? -39.58782 -4.82537 1.44540   1.000 14.90641 ? 72  SER A N   1 
ATOM   556  C  CA  . SER A 1 72  ? -41.01023 -4.76798 1.11986   1.000 17.23396 ? 72  SER A CA  1 
ATOM   557  C  C   . SER A 1 72  ? -41.36959 -3.58307 0.23252   1.000 21.50357 ? 72  SER A C   1 
ATOM   558  O  O   . SER A 1 72  ? -42.41390 -3.62011 -0.42218  1.000 20.73319 ? 72  SER A O   1 
ATOM   559  C  CB  . SER A 1 72  ? -41.84564 -4.73170 2.40691   1.000 22.56191 ? 72  SER A CB  1 
ATOM   560  O  OG  . SER A 1 72  ? -41.44817 -3.67666 3.26660   1.000 20.14835 ? 72  SER A OG  1 
ATOM   561  N  N   . ALA A 1 73  ? -40.52304 -2.54324 0.16809   1.000 18.57159 ? 73  ALA A N   1 
ATOM   562  C  CA  . ALA A 1 73  ? -40.82595 -1.37149 -0.64683  1.000 17.92497 ? 73  ALA A CA  1 
ATOM   563  C  C   . ALA A 1 73  ? -40.15635 -1.40340 -2.01171  1.000 16.23018 ? 73  ALA A C   1 
ATOM   564  O  O   . ALA A 1 73  ? -40.62570 -0.73368 -2.93979  1.000 15.48758 ? 73  ALA A O   1 
ATOM   565  C  CB  . ALA A 1 73  ? -40.41339 -0.08682 0.09221   1.000 18.78938 ? 73  ALA A CB  1 
ATOM   566  N  N   . ASN A 1 74  ? -39.05762 -2.12958 -2.14226  1.000 12.92833 ? 74  ASN A N   1 
ATOM   567  C  CA  . ASN A 1 74  ? -38.40768 -2.28503 -3.43400  1.000 20.46190 ? 74  ASN A CA  1 
ATOM   568  C  C   . ASN A 1 74  ? -37.63342 -3.58915 -3.37939  1.000 12.99733 ? 74  ASN A C   1 
ATOM   569  O  O   . ASN A 1 74  ? -36.98192 -3.86817 -2.37027  1.000 17.81290 ? 74  ASN A O   1 
ATOM   570  C  CB  . ASN A 1 74  ? -37.49329 -1.08684 -3.73509  1.000 15.17390 ? 74  ASN A CB  1 
ATOM   571  C  CG  . ASN A 1 74  ? -36.63372 -1.30291 -4.96476  1.000 15.44675 ? 74  ASN A CG  1 
ATOM   572  O  OD1 . ASN A 1 74  ? -35.65647 -2.04798 -4.91477  1.000 15.84100 ? 74  ASN A OD1 1 
ATOM   573  N  ND2 . ASN A 1 74  ? -36.98828 -0.64429 -6.07087  1.000 14.33413 ? 74  ASN A ND2 1 
ATOM   574  N  N   . LEU A 1 75  ? -37.73832 -4.38864 -4.45197  1.000 20.55328 ? 75  LEU A N   1 
ATOM   575  C  CA  . LEU A 1 75  ? -37.15329 -5.72845 -4.48410  1.000 25.26930 ? 75  LEU A CA  1 
ATOM   576  C  C   . LEU A 1 75  ? -35.68818 -5.72694 -4.08030  1.000 20.54479 ? 75  LEU A C   1 
ATOM   577  O  O   . LEU A 1 75  ? -35.21417 -6.65282 -3.40923  1.000 18.16568 ? 75  LEU A O   1 
ATOM   578  C  CB  . LEU A 1 75  ? -37.31051 -6.30903 -5.89178  1.000 22.27376 ? 75  LEU A CB  1 
ATOM   579  C  CG  . LEU A 1 75  ? -37.48568 -7.80980 -6.08573  1.000 32.07490 ? 75  LEU A CG  1 
ATOM   580  C  CD1 . LEU A 1 75  ? -38.80735 -8.29984 -5.53517  1.000 31.23665 ? 75  LEU A CD1 1 
ATOM   581  C  CD2 . LEU A 1 75  ? -37.41315 -8.05783 -7.57931  1.000 25.76458 ? 75  LEU A CD2 1 
ATOM   582  N  N   A ASN A 1 76  ? -34.95080 -4.70048 -4.49272  0.725 17.33531 ? 76  ASN A N   1 
ATOM   583  N  N   B ASN A 1 76  ? -34.94659 -4.69475 -4.48203  0.275 17.37236 ? 76  ASN A N   1 
ATOM   584  C  CA  A ASN A 1 76  ? -33.51855 -4.62412 -4.24235  0.725 17.35786 ? 76  ASN A CA  1 
ATOM   585  C  CA  B ASN A 1 76  ? -33.51230 -4.61347 -4.22970  0.275 17.32418 ? 76  ASN A CA  1 
ATOM   586  C  C   A ASN A 1 76  ? -33.16272 -3.60086 -3.16730  0.725 14.06156 ? 76  ASN A C   1 
ATOM   587  C  C   B ASN A 1 76  ? -33.16075 -3.59286 -3.15700  0.275 14.19432 ? 76  ASN A C   1 
ATOM   588  O  O   A ASN A 1 76  ? -32.00581 -3.18793 -3.08018  0.725 16.79178 ? 76  ASN A O   1 
ATOM   589  O  O   B ASN A 1 76  ? -32.01034 -3.15360 -3.07965  0.275 16.74185 ? 76  ASN A O   1 
ATOM   590  C  CB  A ASN A 1 76  ? -32.78054 -4.31337 -5.54775  0.725 15.18298 ? 76  ASN A CB  1 
ATOM   591  C  CB  B ASN A 1 76  ? -32.77314 -4.28637 -5.52447  0.275 15.29144 ? 76  ASN A CB  1 
ATOM   592  C  CG  A ASN A 1 76  ? -31.34960 -4.83228 -5.54831  0.725 15.08803 ? 76  ASN A CG  1 
ATOM   593  C  CG  B ASN A 1 76  ? -33.22006 -5.14836 -6.66400  0.275 16.03755 ? 76  ASN A CG  1 
ATOM   594  O  OD1 A ASN A 1 76  ? -31.05195 -5.89355 -4.97882  0.725 13.68586 ? 76  ASN A OD1 1 
ATOM   595  O  OD1 B ASN A 1 76  ? -32.98481 -6.35410 -6.66780  0.275 22.81712 ? 76  ASN A OD1 1 
ATOM   596  N  ND2 A ASN A 1 76  ? -30.45444 -4.09015 -6.19753  0.725 16.06870 ? 76  ASN A ND2 1 
ATOM   597  N  ND2 B ASN A 1 76  ? -33.90235 -4.55103 -7.63209  0.275 20.37473 ? 76  ASN A ND2 1 
ATOM   598  N  N   . LYS A 1 77  ? -34.12329 -3.22222 -2.31625  1.000 13.21969 ? 77  LYS A N   1 
ATOM   599  C  CA  . LYS A 1 77  ? -33.92138 -2.16980 -1.31749  1.000 15.28935 ? 77  LYS A CA  1 
ATOM   600  C  C   . LYS A 1 77  ? -33.38542 -0.87877 -1.94598  1.000 10.22385 ? 77  LYS A C   1 
ATOM   601  O  O   . LYS A 1 77  ? -32.62544 -0.12861 -1.31798  1.000 13.20820 ? 77  LYS A O   1 
ATOM   602  C  CB  . LYS A 1 77  ? -33.01114 -2.63989 -0.17871  1.000 18.77877 ? 77  LYS A CB  1 
ATOM   603  C  CG  . LYS A 1 77  ? -33.48081 -3.93252 0.44382   1.000 22.65095 ? 77  LYS A CG  1 
ATOM   604  C  CD  . LYS A 1 77  ? -33.04669 -4.06480 1.89913   1.000 27.83738 ? 77  LYS A CD  1 
ATOM   605  C  CE  . LYS A 1 77  ? -31.82068 -4.93681 2.00754   1.000 29.35916 ? 77  LYS A CE  1 
ATOM   606  N  NZ  . LYS A 1 77  ? -31.58028 -5.41409 3.40536   1.000 35.37158 ? 77  LYS A NZ  1 
ATOM   607  N  N   . CYS A 1 78  ? -33.77089 -0.61762 -3.18986  1.000 14.00599 ? 78  CYS A N   1 
ATOM   608  C  CA  . CYS A 1 78  ? -33.53162 0.67495  -3.83077  1.000 16.56971 ? 78  CYS A CA  1 
ATOM   609  C  C   . CYS A 1 78  ? -34.64390 1.65640  -3.49978  1.000 12.84749 ? 78  CYS A C   1 
ATOM   610  O  O   . CYS A 1 78  ? -35.83018 1.32145  -3.59224  1.000 13.42361 ? 78  CYS A O   1 
ATOM   611  C  CB  . CYS A 1 78  ? -33.48815 0.56620  -5.35704  1.000 14.17541 ? 78  CYS A CB  1 
ATOM   612  S  SG  . CYS A 1 78  ? -32.41334 -0.66165 -6.07490  1.000 16.15702 ? 78  CYS A SG  1 
ATOM   613  N  N   . TRP A 1 79  ? -34.25716 2.88958  -3.17236  1.000 14.06987 ? 79  TRP A N   1 
ATOM   614  C  CA  . TRP A 1 79  ? -35.20269 3.98972  -3.24554  1.000 13.89853 ? 79  TRP A CA  1 
ATOM   615  C  C   . TRP A 1 79  ? -35.79703 4.00783  -4.64066  1.000 14.95180 ? 79  TRP A C   1 
ATOM   616  O  O   . TRP A 1 79  ? -35.08094 3.82142  -5.63282  1.000 13.19726 ? 79  TRP A O   1 
ATOM   617  C  CB  . TRP A 1 79  ? -34.50111 5.32018  -2.92843  1.000 9.85959  ? 79  TRP A CB  1 
ATOM   618  C  CG  . TRP A 1 79  ? -33.90142 5.27944  -1.58187  1.000 10.16121 ? 79  TRP A CG  1 
ATOM   619  C  CD1 . TRP A 1 79  ? -32.58614 5.12007  -1.27340  1.000 9.98068  ? 79  TRP A CD1 1 
ATOM   620  C  CD2 . TRP A 1 79  ? -34.60485 5.35121  -0.34844  1.000 9.64944  ? 79  TRP A CD2 1 
ATOM   621  N  NE1 . TRP A 1 79  ? -32.42152 5.09948  0.09966   1.000 9.81905  ? 79  TRP A NE1 1 
ATOM   622  C  CE2 . TRP A 1 79  ? -33.65464 5.24152  0.68357   1.000 10.34948 ? 79  TRP A CE2 1 
ATOM   623  C  CE3 . TRP A 1 79  ? -35.95809 5.50813  -0.01400  1.000 10.47745 ? 79  TRP A CE3 1 
ATOM   624  C  CZ2 . TRP A 1 79  ? -34.01320 5.27292  2.03774   1.000 12.87293 ? 79  TRP A CZ2 1 
ATOM   625  C  CZ3 . TRP A 1 79  ? -36.31168 5.54865  1.32505   1.000 13.23939 ? 79  TRP A CZ3 1 
ATOM   626  C  CH2 . TRP A 1 79  ? -35.34537 5.43319  2.33333   1.000 14.39350 ? 79  TRP A CH2 1 
ATOM   627  N  N   . ASN A 1 80  ? -37.11905 4.19804  -4.71771  1.000 9.14460  ? 80  ASN A N   1 
ATOM   628  C  CA  . ASN A 1 80  ? -37.82763 4.09628  -5.99896  1.000 12.01429 ? 80  ASN A CA  1 
ATOM   629  C  C   . ASN A 1 80  ? -37.72742 5.40789  -6.79289  1.000 10.87527 ? 80  ASN A C   1 
ATOM   630  O  O   . ASN A 1 80  ? -38.71553 6.06389  -7.12742  1.000 13.45687 ? 80  ASN A O   1 
ATOM   631  C  CB  . ASN A 1 80  ? -39.27913 3.69236  -5.76542  1.000 11.31938 ? 80  ASN A CB  1 
ATOM   632  C  CG  . ASN A 1 80  ? -39.41879 2.23601  -5.34727  1.000 14.40060 ? 80  ASN A CG  1 
ATOM   633  O  OD1 . ASN A 1 80  ? -39.01771 1.33791  -6.07202  1.000 13.75213 ? 80  ASN A OD1 1 
ATOM   634  N  ND2 . ASN A 1 80  ? -39.98966 1.99978  -4.15805  1.000 16.09398 ? 80  ASN A ND2 1 
ATOM   635  N  N   . TRP A 1 81  ? -36.48522 5.77648  -7.11080  1.000 11.95577 ? 81  TRP A N   1 
ATOM   636  C  CA  . TRP A 1 81  ? -36.20995 7.04335  -7.78805  1.000 10.99541 ? 81  TRP A CA  1 
ATOM   637  C  C   . TRP A 1 81  ? -36.78508 7.09259  -9.19782  1.000 7.51319  ? 81  TRP A C   1 
ATOM   638  O  O   . TRP A 1 81  ? -36.93475 8.18559  -9.75231  1.000 10.10993 ? 81  TRP A O   1 
ATOM   639  C  CB  . TRP A 1 81  ? -34.69181 7.27008  -7.85557  1.000 12.10571 ? 81  TRP A CB  1 
ATOM   640  C  CG  . TRP A 1 81  ? -34.01478 6.16417  -8.60183  1.000 10.11625 ? 81  TRP A CG  1 
ATOM   641  C  CD1 . TRP A 1 81  ? -33.47775 5.02892  -8.06418  1.000 8.12793  ? 81  TRP A CD1 1 
ATOM   642  C  CD2 . TRP A 1 81  ? -33.82984 6.06081  -10.02544 1.000 11.43314 ? 81  TRP A CD2 1 
ATOM   643  N  NE1 . TRP A 1 81  ? -32.96611 4.22805  -9.06167  1.000 9.70844  ? 81  TRP A NE1 1 
ATOM   644  C  CE2 . TRP A 1 81  ? -33.17489 4.83257  -10.27268 1.000 10.92380 ? 81  TRP A CE2 1 
ATOM   645  C  CE3 . TRP A 1 81  ? -34.15107 6.88616  -11.10984 1.000 10.13191 ? 81  TRP A CE3 1 
ATOM   646  C  CZ2 . TRP A 1 81  ? -32.83013 4.40635  -11.56371 1.000 15.05074 ? 81  TRP A CZ2 1 
ATOM   647  C  CZ3 . TRP A 1 81  ? -33.81158 6.46080  -12.39601 1.000 15.41380 ? 81  TRP A CZ3 1 
ATOM   648  C  CH2 . TRP A 1 81  ? -33.16073 5.23308  -12.60839 1.000 11.13289 ? 81  TRP A CH2 1 
ATOM   649  N  N   . PHE A 1 82  ? -37.07386 5.93361  -9.79335  1.000 9.72696  ? 82  PHE A N   1 
ATOM   650  C  CA  . PHE A 1 82  ? -37.55658 5.78192  -11.16676 1.000 15.28724 ? 82  PHE A CA  1 
ATOM   651  C  C   . PHE A 1 82  ? -39.07912 5.75668  -11.26825 1.000 16.78875 ? 82  PHE A C   1 
ATOM   652  O  O   . PHE A 1 82  ? -39.61684 5.62006  -12.37768 1.000 17.42712 ? 82  PHE A O   1 
ATOM   653  C  CB  . PHE A 1 82  ? -37.01827 4.47241  -11.74364 1.000 11.92624 ? 82  PHE A CB  1 
ATOM   654  C  CG  . PHE A 1 82  ? -37.23897 3.31698  -10.82736 1.000 14.26873 ? 82  PHE A CG  1 
ATOM   655  C  CD1 . PHE A 1 82  ? -38.49556 2.73685  -10.72559 1.000 19.50107 ? 82  PHE A CD1 1 
ATOM   656  C  CD2 . PHE A 1 82  ? -36.20808 2.83356  -10.03456 1.000 13.30518 ? 82  PHE A CD2 1 
ATOM   657  C  CE1 . PHE A 1 82  ? -38.72130 1.67948  -9.86990  1.000 18.65256 ? 82  PHE A CE1 1 
ATOM   658  C  CE2 . PHE A 1 82  ? -36.43055 1.78422  -9.15374  1.000 11.85919 ? 82  PHE A CE2 1 
ATOM   659  C  CZ  . PHE A 1 82  ? -37.69071 1.20588  -9.08116  1.000 13.71023 ? 82  PHE A CZ  1 
ATOM   660  N  N   . ASP A 1 83  ? -39.77782 5.86631  -10.14064 1.000 13.55876 ? 83  ASP A N   1 
ATOM   661  C  CA  . ASP A 1 83  ? -41.21930 5.64068  -10.04277 1.000 13.46990 ? 83  ASP A CA  1 
ATOM   662  C  C   . ASP A 1 83  ? -41.92545 6.96799  -9.77290  1.000 14.20319 ? 83  ASP A C   1 
ATOM   663  O  O   . ASP A 1 83  ? -41.62509 7.64106  -8.78025  1.000 14.50659 ? 83  ASP A O   1 
ATOM   664  C  CB  . ASP A 1 83  ? -41.48380 4.63202  -8.92619  1.000 13.21335 ? 83  ASP A CB  1 
ATOM   665  C  CG  . ASP A 1 83  ? -42.95193 4.24691  -8.78367  1.000 16.54367 ? 83  ASP A CG  1 
ATOM   666  O  OD1 . ASP A 1 83  ? -43.84129 5.06078  -9.11216  1.000 18.03504 ? 83  ASP A OD1 1 
ATOM   667  O  OD2 . ASP A 1 83  ? -43.19137 3.10887  -8.33018  1.000 32.22072 ? 83  ASP A OD2 1 
ATOM   668  N  N   . SER A 1 84  ? -42.86404 7.33979  -10.65542 1.000 12.59730 ? 84  SER A N   1 
ATOM   669  C  CA  . SER A 1 84  ? -43.61211 8.58800  -10.49052 1.000 19.30419 ? 84  SER A CA  1 
ATOM   670  C  C   . SER A 1 84  ? -44.23510 8.71102  -9.11022  1.000 19.93885 ? 84  SER A C   1 
ATOM   671  O  O   . SER A 1 84  ? -44.42215 9.83125  -8.60878  1.000 19.73325 ? 84  SER A O   1 
ATOM   672  C  CB  . SER A 1 84  ? -44.72548 8.67915  -11.53196 1.000 21.14941 ? 84  SER A CB  1 
ATOM   673  O  OG  . SER A 1 84  ? -44.22799 8.38406  -12.81082 1.000 32.03897 ? 84  SER A OG  1 
ATOM   674  N  N   . ASN A 1 85  ? -44.59686 7.58217  -8.49327  1.000 18.42017 ? 85  ASN A N   1 
ATOM   675  C  CA  . ASN A 1 85  ? -45.21452 7.62699  -7.17254  1.000 18.45880 ? 85  ASN A CA  1 
ATOM   676  C  C   . ASN A 1 85  ? -44.27065 8.16930  -6.12011  1.000 18.61802 ? 85  ASN A C   1 
ATOM   677  O  O   . ASN A 1 85  ? -44.72698 8.57755  -5.04126  1.000 18.88271 ? 85  ASN A O   1 
ATOM   678  C  CB  . ASN A 1 85  ? -45.68666 6.23936  -6.74490  1.000 19.99414 ? 85  ASN A CB  1 
ATOM   679  C  CG  . ASN A 1 85  ? -46.97287 5.81457  -7.43210  1.000 28.54665 ? 85  ASN A CG  1 
ATOM   680  O  OD1 . ASN A 1 85  ? -47.61755 6.60366  -8.13784  1.000 25.61873 ? 85  ASN A OD1 1 
ATOM   681  N  ND2 . ASN A 1 85  ? -47.34023 4.54838  -7.24745  1.000 34.57824 ? 85  ASN A ND2 1 
ATOM   682  N  N   . HIS A 1 86  ? -42.96762 8.19431  -6.41165  1.000 13.55619 ? 86  HIS A N   1 
ATOM   683  C  CA  . HIS A 1 86  ? -41.95740 8.53819  -5.42694  1.000 10.62220 ? 86  HIS A CA  1 
ATOM   684  C  C   . HIS A 1 86  ? -41.10493 9.70874  -5.89708  1.000 14.30657 ? 86  HIS A C   1 
ATOM   685  O  O   . HIS A 1 86  ? -39.94684 9.84258  -5.50403  1.000 14.75087 ? 86  HIS A O   1 
ATOM   686  C  CB  . HIS A 1 86  ? -41.11618 7.30854  -5.09742  1.000 14.71262 ? 86  HIS A CB  1 
ATOM   687  C  CG  . HIS A 1 86  ? -41.94403 6.20385  -4.52274  1.000 14.89890 ? 86  HIS A CG  1 
ATOM   688  N  ND1 . HIS A 1 86  ? -42.53389 6.30553  -3.27928  1.000 20.01394 ? 86  HIS A ND1 1 
ATOM   689  C  CD2 . HIS A 1 86  ? -42.36554 5.02673  -5.04805  1.000 19.27059 ? 86  HIS A CD2 1 
ATOM   690  C  CE1 . HIS A 1 86  ? -43.25518 5.22061  -3.04726  1.000 19.69592 ? 86  HIS A CE1 1 
ATOM   691  N  NE2 . HIS A 1 86  ? -43.17182 4.43160  -4.10575  1.000 21.68609 ? 86  HIS A NE2 1 
ATOM   692  N  N   . GLN A 1 87  ? -41.68612 10.57406 -6.72689  1.000 11.66625 ? 87  GLN A N   1 
ATOM   693  C  CA  . GLN A 1 87  ? -40.95252 11.69784 -7.27913  1.000 14.32337 ? 87  GLN A CA  1 
ATOM   694  C  C   . GLN A 1 87  ? -41.56769 13.04616 -6.94958  1.000 12.84265 ? 87  GLN A C   1 
ATOM   695  O  O   . GLN A 1 87  ? -41.04596 14.06884 -7.40827  1.000 15.95998 ? 87  GLN A O   1 
ATOM   696  C  CB  . GLN A 1 87  ? -40.82011 11.54649 -8.80394  1.000 15.09365 ? 87  GLN A CB  1 
ATOM   697  C  CG  . GLN A 1 87  ? -39.90381 10.36933 -9.18927  1.000 12.60318 ? 87  GLN A CG  1 
ATOM   698  C  CD  . GLN A 1 87  ? -40.01108 10.00086 -10.64538 1.000 12.04512 ? 87  GLN A CD  1 
ATOM   699  O  OE1 . GLN A 1 87  ? -40.95609 10.40527 -11.33293 1.000 15.75090 ? 87  GLN A OE1 1 
ATOM   700  N  NE2 . GLN A 1 87  ? -39.03535 9.23475  -11.13807 1.000 14.47069 ? 87  GLN A NE2 1 
ATOM   701  N  N   . SER A 1 88  ? -42.64291 13.08452 -6.16537  1.000 11.51140 ? 88  SER A N   1 
ATOM   702  C  CA  . SER A 1 88  ? -43.36890 14.31374 -5.89897  1.000 12.46243 ? 88  SER A CA  1 
ATOM   703  C  C   . SER A 1 88  ? -43.47606 14.58031 -4.40666  1.000 13.20052 ? 88  SER A C   1 
ATOM   704  O  O   . SER A 1 88  ? -43.49585 13.65221 -3.58525  1.000 16.87119 ? 88  SER A O   1 
ATOM   705  C  CB  . SER A 1 88  ? -44.78091 14.26303 -6.49130  1.000 14.71707 ? 88  SER A CB  1 
ATOM   706  O  OG  . SER A 1 88  ? -44.71605 14.25702 -7.90423  1.000 25.69053 ? 88  SER A OG  1 
ATOM   707  N  N   . ARG A 1 89  ? -43.56949 15.86743 -4.07968  1.000 13.84912 ? 89  ARG A N   1 
ATOM   708  C  CA  . ARG A 1 89  ? -43.78996 16.29421 -2.70929  1.000 11.38773 ? 89  ARG A CA  1 
ATOM   709  C  C   . ARG A 1 89  ? -45.11184 15.74511 -2.18048  1.000 17.22793 ? 89  ARG A C   1 
ATOM   710  O  O   . ARG A 1 89  ? -46.10120 15.62854 -2.91212  1.000 14.89677 ? 89  ARG A O   1 
ATOM   711  C  CB  . ARG A 1 89  ? -43.81895 17.82991 -2.62728  1.000 12.08820 ? 89  ARG A CB  1 
ATOM   712  C  CG  . ARG A 1 89  ? -44.00178 18.35325 -1.20889  1.000 9.96682  ? 89  ARG A CG  1 
ATOM   713  C  CD  . ARG A 1 89  ? -44.32913 19.86030 -1.19501  1.000 15.21489 ? 89  ARG A CD  1 
ATOM   714  N  NE  . ARG A 1 89  ? -44.30903 20.40067 0.16024   1.000 14.12811 ? 89  ARG A NE  1 
ATOM   715  C  CZ  . ARG A 1 89  ? -43.23489 20.94603 0.71542   1.000 14.63447 ? 89  ARG A CZ  1 
ATOM   716  N  NH1 . ARG A 1 89  ? -42.07653 21.02111 0.06132   1.000 11.21761 ? 89  ARG A NH1 1 
ATOM   717  N  NH2 . ARG A 1 89  ? -43.30926 21.38855 1.96800   1.000 13.00464 ? 89  ARG A NH2 1 
ATOM   718  N  N   . GLY A 1 90  ? -45.12982 15.42515 -0.88606  1.000 13.69751 ? 90  GLY A N   1 
ATOM   719  C  CA  . GLY A 1 90  ? -46.37478 15.19027 -0.16829  1.000 15.82496 ? 90  GLY A CA  1 
ATOM   720  C  C   . GLY A 1 90  ? -46.86941 13.75983 -0.13139  1.000 15.81838 ? 90  GLY A C   1 
ATOM   721  O  O   . GLY A 1 90  ? -47.80221 13.46254 0.64401   1.000 17.43123 ? 90  GLY A O   1 
ATOM   722  N  N   . ARG A 1 91  ? -46.28683 12.87395 -0.93663  1.000 14.66977 ? 91  ARG A N   1 
ATOM   723  C  CA  . ARG A 1 91  ? -46.65354 11.46826 -1.01783  1.000 21.14603 ? 91  ARG A CA  1 
ATOM   724  C  C   . ARG A 1 91  ? -45.40432 10.61391 -1.20820  1.000 17.95632 ? 91  ARG A C   1 
ATOM   725  O  O   . ARG A 1 91  ? -44.33906 11.10767 -1.58547  1.000 15.98148 ? 91  ARG A O   1 
ATOM   726  C  CB  . ARG A 1 91  ? -47.63503 11.22040 -2.18030  1.000 18.41684 ? 91  ARG A CB  1 
ATOM   727  C  CG  . ARG A 1 91  ? -49.05941 11.18610 -1.73764  1.000 38.42467 ? 91  ARG A CG  1 
ATOM   728  C  CD  . ARG A 1 91  ? -49.49099 9.72526  -1.69932  1.000 49.97703 ? 91  ARG A CD  1 
ATOM   729  N  NE  . ARG A 1 91  ? -50.80915 9.57137  -1.10546  1.000 56.27168 ? 91  ARG A NE  1 
ATOM   730  C  CZ  . ARG A 1 91  ? -51.03598 9.58493  0.20410   1.000 64.32415 ? 91  ARG A CZ  1 
ATOM   731  N  NH1 . ARG A 1 91  ? -50.04945 9.72512  1.08620   1.000 42.76485 ? 91  ARG A NH1 1 
ATOM   732  N  NH2 . ARG A 1 91  ? -52.28268 9.46657  0.64052   1.000 48.50334 ? 91  ARG A NH2 1 
ATOM   733  N  N   . GLY A 1 92  ? -45.56068 9.30886  -0.97770  1.000 16.98535 ? 92  GLY A N   1 
ATOM   734  C  CA  . GLY A 1 92  ? -44.53002 8.32070  -1.23078  1.000 13.59598 ? 92  GLY A CA  1 
ATOM   735  C  C   . GLY A 1 92  ? -43.26797 8.56796  -0.42042  1.000 16.34224 ? 92  GLY A C   1 
ATOM   736  O  O   . GLY A 1 92  ? -43.27798 9.15799  0.66355   1.000 9.97668  ? 92  GLY A O   1 
ATOM   737  N  N   . GLU A 1 93  ? -42.16020 8.12063  -0.97170  1.000 15.38909 ? 93  GLU A N   1 
ATOM   738  C  CA  . GLU A 1 93  ? -40.90123 8.14292  -0.25193  1.000 13.86100 ? 93  GLU A CA  1 
ATOM   739  C  C   . GLU A 1 93  ? -40.42891 9.57169  0.00019   1.000 9.49513  ? 93  GLU A C   1 
ATOM   740  O  O   . GLU A 1 93  ? -39.85135 9.83046  1.06225   1.000 13.69973 ? 93  GLU A O   1 
ATOM   741  C  CB  . GLU A 1 93  ? -39.87576 7.29045  -0.99924  1.000 14.09421 ? 93  GLU A CB  1 
ATOM   742  C  CG  . GLU A 1 93  ? -40.32313 5.82054  -1.00881  1.000 15.09516 ? 93  GLU A CG  1 
ATOM   743  C  CD  . GLU A 1 93  ? -39.57289 4.91915  -1.96614  1.000 15.22749 ? 93  GLU A CD  1 
ATOM   744  O  OE1 . GLU A 1 93  ? -38.56710 5.34960  -2.57128  1.000 16.15996 ? 93  GLU A OE1 1 
ATOM   745  O  OE2 . GLU A 1 93  ? -40.04579 3.76898  -2.13647  1.000 15.94002 ? 93  GLU A OE2 1 
ATOM   746  N  N   . PRO A 1 94  ? -40.64132 10.53089 -0.91367  1.000 13.39847 ? 94  PRO A N   1 
ATOM   747  C  CA  . PRO A 1 94  ? -40.27307 11.91736 -0.56203  1.000 9.31198  ? 94  PRO A CA  1 
ATOM   748  C  C   . PRO A 1 94  ? -40.97502 12.38423 0.69899   1.000 13.24896 ? 94  PRO A C   1 
ATOM   749  O  O   . PRO A 1 94  ? -40.32941 12.92100 1.61315   1.000 11.72191 ? 94  PRO A O   1 
ATOM   750  C  CB  . PRO A 1 94  ? -40.67621 12.71351 -1.81021  1.000 13.81827 ? 94  PRO A CB  1 
ATOM   751  C  CG  . PRO A 1 94  ? -40.49042 11.73227 -2.93282  1.000 11.66731 ? 94  PRO A CG  1 
ATOM   752  C  CD  . PRO A 1 94  ? -40.92923 10.39126 -2.35717  1.000 11.54260 ? 94  PRO A CD  1 
ATOM   753  N  N   . ALA A 1 95  ? -42.28907 12.14945 0.79080   1.000 11.58926 ? 95  ALA A N   1 
ATOM   754  C  CA  . ALA A 1 95  ? -43.01058 12.48062 2.01446   1.000 13.65754 ? 95  ALA A CA  1 
ATOM   755  C  C   . ALA A 1 95  ? -42.45013 11.72613 3.21113   1.000 10.28973 ? 95  ALA A C   1 
ATOM   756  O  O   . ALA A 1 95  ? -42.34286 12.27635 4.31612   1.000 12.99731 ? 95  ALA A O   1 
ATOM   757  C  CB  . ALA A 1 95  ? -44.50154 12.16906 1.83859   1.000 15.80573 ? 95  ALA A CB  1 
ATOM   758  N  N   . SER A 1 96  ? -42.11395 10.45293 3.02329   1.000 10.16459 ? 96  SER A N   1 
ATOM   759  C  CA  . SER A 1 96  ? -41.63635 9.65529  4.14890   1.000 10.27912 ? 96  SER A CA  1 
ATOM   760  C  C   . SER A 1 96  ? -40.28680 10.16598 4.63251   1.000 12.65023 ? 96  SER A C   1 
ATOM   761  O  O   . SER A 1 96  ? -40.03783 10.24550 5.84154   1.000 8.94326  ? 96  SER A O   1 
ATOM   762  C  CB  . SER A 1 96  ? -41.54296 8.18118  3.74132   1.000 13.31284 ? 96  SER A CB  1 
ATOM   763  O  OG  . SER A 1 96  ? -41.30787 7.34206  4.86097   1.000 12.54316 ? 96  SER A OG  1 
ATOM   764  N  N   . ILE A 1 97  ? -39.40546 10.52030 3.69517   1.000 11.97288 ? 97  ILE A N   1 
ATOM   765  C  CA  . ILE A 1 97  ? -38.09567 11.02903 4.08328   1.000 10.36769 ? 97  ILE A CA  1 
ATOM   766  C  C   . ILE A 1 97  ? -38.23073 12.40363 4.72746   1.000 10.67263 ? 97  ILE A C   1 
ATOM   767  O  O   . ILE A 1 97  ? -37.57523 12.69783 5.73708   1.000 10.25262 ? 97  ILE A O   1 
ATOM   768  C  CB  . ILE A 1 97  ? -37.15237 11.03798 2.86648   1.000 7.59543  ? 97  ILE A CB  1 
ATOM   769  C  CG1 . ILE A 1 97  ? -36.83007 9.59538  2.45936   1.000 9.64006  ? 97  ILE A CG1 1 
ATOM   770  C  CG2 . ILE A 1 97  ? -35.85899 11.82160 3.21667   1.000 13.66797 ? 97  ILE A CG2 1 
ATOM   771  C  CD1 . ILE A 1 97  ? -36.24075 9.41310  1.04273   1.000 11.82805 ? 97  ILE A CD1 1 
ATOM   772  N  N   . ALA A 1 98  ? -39.08121 13.26686 4.16875   1.000 10.88011 ? 98  ALA A N   1 
ATOM   773  C  CA  . ALA A 1 98  ? -39.37935 14.51397 4.85892   1.000 11.56790 ? 98  ALA A CA  1 
ATOM   774  C  C   . ALA A 1 98  ? -39.92758 14.22741 6.24796   1.000 10.38049 ? 98  ALA A C   1 
ATOM   775  O  O   . ALA A 1 98  ? -39.61888 14.93883 7.21258   1.000 12.92603 ? 98  ALA A O   1 
ATOM   776  C  CB  . ALA A 1 98  ? -40.37725 15.35600 4.04579   1.000 10.53134 ? 98  ALA A CB  1 
ATOM   777  N  N   . GLY A 1 99  ? -40.73330 13.17343 6.36484   1.000 11.41220 ? 99  GLY A N   1 
ATOM   778  C  CA  . GLY A 1 99  ? -41.27766 12.79265 7.66190   1.000 11.88168 ? 99  GLY A CA  1 
ATOM   779  C  C   . GLY A 1 99  ? -40.20494 12.42276 8.67305   1.000 13.34108 ? 99  GLY A C   1 
ATOM   780  O  O   . GLY A 1 99  ? -40.33305 12.71106 9.87003   1.000 13.57442 ? 99  GLY A O   1 
ATOM   781  N  N   . VAL A 1 100 ? -39.13110 11.78254 8.21464   1.000 10.25997 ? 100 VAL A N   1 
ATOM   782  C  CA  . VAL A 1 100 ? -38.04769 11.45168 9.13168   1.000 10.86540 ? 100 VAL A CA  1 
ATOM   783  C  C   . VAL A 1 100 ? -37.40746 12.73120 9.64957   1.000 15.88953 ? 100 VAL A C   1 
ATOM   784  O  O   . VAL A 1 100 ? -37.10401 12.85626 10.83983  1.000 13.20632 ? 100 VAL A O   1 
ATOM   785  C  CB  . VAL A 1 100 ? -37.02108 10.52432 8.45110   1.000 9.65851  ? 100 VAL A CB  1 
ATOM   786  C  CG1 . VAL A 1 100 ? -35.72685 10.40548 9.29378   1.000 9.91654  ? 100 VAL A CG1 1 
ATOM   787  C  CG2 . VAL A 1 100 ? -37.62571 9.13510  8.21819   1.000 8.78917  ? 100 VAL A CG2 1 
ATOM   788  N  N   . VAL A 1 101 ? -37.22151 13.71768 8.77155   1.000 11.30935 ? 101 VAL A N   1 
ATOM   789  C  CA  . VAL A 1 101 ? -36.65936 14.98580 9.22314   1.000 12.90697 ? 101 VAL A CA  1 
ATOM   790  C  C   . VAL A 1 101 ? -37.57452 15.61673 10.25671  1.000 11.08698 ? 101 VAL A C   1 
ATOM   791  O  O   . VAL A 1 101 ? -37.12482 16.10150 11.30278  1.000 11.88232 ? 101 VAL A O   1 
ATOM   792  C  CB  . VAL A 1 101 ? -36.42611 15.92991 8.03343   1.000 10.83410 ? 101 VAL A CB  1 
ATOM   793  C  CG1 . VAL A 1 101 ? -36.05943 17.31681 8.54785   1.000 14.24961 ? 101 VAL A CG1 1 
ATOM   794  C  CG2 . VAL A 1 101 ? -35.35436 15.34897 7.09200   1.000 11.32493 ? 101 VAL A CG2 1 
ATOM   795  N  N   . GLU A 1 102 ? -38.87891 15.62445 9.97511   1.000 13.62707 ? 102 GLU A N   1 
ATOM   796  C  CA  . GLU A 1 102 ? -39.80137 16.21723 10.93219  1.000 16.87124 ? 102 GLU A CA  1 
ATOM   797  C  C   . GLU A 1 102 ? -39.74590 15.47194 12.26296  1.000 16.72884 ? 102 GLU A C   1 
ATOM   798  O  O   . GLU A 1 102 ? -39.82226 16.08760 13.33328  1.000 17.30304 ? 102 GLU A O   1 
ATOM   799  C  CB  . GLU A 1 102 ? -41.22479 16.22747 10.36430  1.000 18.65643 ? 102 GLU A CB  1 
ATOM   800  C  CG  . GLU A 1 102 ? -42.25479 16.73701 11.36802  1.000 35.28328 ? 102 GLU A CG  1 
ATOM   801  C  CD  . GLU A 1 102 ? -43.65451 16.20971 11.10403  1.000 50.59306 ? 102 GLU A CD  1 
ATOM   802  O  OE1 . GLU A 1 102 ? -44.27713 15.65939 12.04060  1.000 50.20095 ? 102 GLU A OE1 1 
ATOM   803  O  OE2 . GLU A 1 102 ? -44.14343 16.36870 9.96484   1.000 47.69620 ? 102 GLU A OE2 1 
ATOM   804  N  N   . ASP A 1 103 ? -39.61935 14.14094 12.21449  1.000 16.96231 ? 103 ASP A N   1 
ATOM   805  C  CA  . ASP A 1 103 ? -39.52868 13.36204 13.44683  1.000 12.10800 ? 103 ASP A CA  1 
ATOM   806  C  C   . ASP A 1 103 ? -38.27594 13.72655 14.22862  1.000 15.75909 ? 103 ASP A C   1 
ATOM   807  O  O   . ASP A 1 103 ? -38.31513 13.87059 15.45853  1.000 17.46052 ? 103 ASP A O   1 
ATOM   808  C  CB  . ASP A 1 103 ? -39.55848 11.87003 13.10797  1.000 14.71538 ? 103 ASP A CB  1 
ATOM   809  C  CG  . ASP A 1 103 ? -39.96443 11.00903 14.29092  1.000 24.76477 ? 103 ASP A CG  1 
ATOM   810  O  OD1 . ASP A 1 103 ? -41.00360 11.30729 14.90563  1.000 19.78929 ? 103 ASP A OD1 1 
ATOM   811  O  OD2 . ASP A 1 103 ? -39.27882 10.00906 14.57863  1.000 17.84069 ? 103 ASP A OD2 1 
ATOM   812  N  N   . VAL A 1 104 ? -37.14765 13.88369 13.53636  1.000 11.90923 ? 104 VAL A N   1 
ATOM   813  C  CA  . VAL A 1 104 ? -35.92089 14.23850 14.23992  1.000 9.81544  ? 104 VAL A CA  1 
ATOM   814  C  C   . VAL A 1 104 ? -36.02185 15.65100 14.79359  1.000 15.05279 ? 104 VAL A C   1 
ATOM   815  O  O   . VAL A 1 104 ? -35.57255 15.92636 15.91649  1.000 17.13119 ? 104 VAL A O   1 
ATOM   816  C  CB  . VAL A 1 104 ? -34.70727 14.07304 13.30865  1.000 13.50925 ? 104 VAL A CB  1 
ATOM   817  C  CG1 . VAL A 1 104 ? -33.42769 14.53001 14.01162  1.000 9.40016  ? 104 VAL A CG1 1 
ATOM   818  C  CG2 . VAL A 1 104 ? -34.60929 12.61052 12.83388  1.000 16.12807 ? 104 VAL A CG2 1 
ATOM   819  N  N   . LYS A 1 105 ? -36.59635 16.57390 14.00589  1.000 12.90373 ? 105 LYS A N   1 
ATOM   820  C  CA  . LYS A 1 105 ? -36.74523 17.95066 14.46816  1.000 11.09421 ? 105 LYS A CA  1 
ATOM   821  C  C   . LYS A 1 105 ? -37.56516 18.00760 15.73398  1.000 17.96897 ? 105 LYS A C   1 
ATOM   822  O  O   . LYS A 1 105 ? -37.31740 18.85539 16.59675  1.000 17.48709 ? 105 LYS A O   1 
ATOM   823  C  CB  . LYS A 1 105 ? -37.40902 18.81690 13.39152  1.000 14.50648 ? 105 LYS A CB  1 
ATOM   824  C  CG  . LYS A 1 105 ? -36.46077 19.23493 12.26546  1.000 11.24790 ? 105 LYS A CG  1 
ATOM   825  C  CD  . LYS A 1 105 ? -37.19456 20.06471 11.24265  1.000 16.20511 ? 105 LYS A CD  1 
ATOM   826  C  CE  . LYS A 1 105 ? -36.22006 20.60424 10.21174  1.000 15.33531 ? 105 LYS A CE  1 
ATOM   827  N  NZ  . LYS A 1 105 ? -36.95740 21.33121 9.17466   1.000 15.17601 ? 105 LYS A NZ  1 
ATOM   828  N  N   A ARG A 1 106 ? -38.55376 17.12106 15.86114  0.526 14.35179 ? 106 ARG A N   1 
ATOM   829  N  N   B ARG A 1 106 ? -38.54829 17.12101 15.86289  0.474 14.37537 ? 106 ARG A N   1 
ATOM   830  C  CA  A ARG A 1 106 ? -39.41245 17.11984 17.03930  0.526 19.83194 ? 106 ARG A CA  1 
ATOM   831  C  CA  B ARG A 1 106 ? -39.40536 17.11890 17.04104  0.474 19.82711 ? 106 ARG A CA  1 
ATOM   832  C  C   A ARG A 1 106 ? -38.71464 16.52695 18.25847  0.526 22.63329 ? 106 ARG A C   1 
ATOM   833  C  C   B ARG A 1 106 ? -38.71105 16.52744 18.25940  0.474 22.63693 ? 106 ARG A C   1 
ATOM   834  O  O   A ARG A 1 106 ? -39.01067 16.92586 19.38899  0.526 22.93389 ? 106 ARG A O   1 
ATOM   835  O  O   B ARG A 1 106 ? -39.00826 16.92550 19.38979  0.474 22.93899 ? 106 ARG A O   1 
ATOM   836  C  CB  A ARG A 1 106 ? -40.71501 16.36342 16.73715  0.526 18.33344 ? 106 ARG A CB  1 
ATOM   837  C  CB  B ARG A 1 106 ? -40.69558 16.36074 16.72411  0.474 18.35133 ? 106 ARG A CB  1 
ATOM   838  C  CG  A ARG A 1 106 ? -41.68851 17.16225 15.86999  0.526 21.32922 ? 106 ARG A CG  1 
ATOM   839  C  CG  B ARG A 1 106 ? -41.70716 17.22313 16.00327  0.474 21.33977 ? 106 ARG A CG  1 
ATOM   840  C  CD  A ARG A 1 106 ? -42.92872 16.36840 15.44954  0.526 28.70301 ? 106 ARG A CD  1 
ATOM   841  C  CD  B ARG A 1 106 ? -42.82394 16.40889 15.39637  0.474 28.65419 ? 106 ARG A CD  1 
ATOM   842  N  NE  A ARG A 1 106 ? -43.41155 15.45981 16.48416  0.526 26.61625 ? 106 ARG A NE  1 
ATOM   843  N  NE  B ARG A 1 106 ? -43.50143 17.18660 14.37001  0.474 29.49762 ? 106 ARG A NE  1 
ATOM   844  C  CZ  A ARG A 1 106 ? -44.51338 14.72688 16.38651  0.526 19.67853 ? 106 ARG A CZ  1 
ATOM   845  C  CZ  B ARG A 1 106 ? -44.81134 17.19634 14.17710  0.474 25.66700 ? 106 ARG A CZ  1 
ATOM   846  N  NH1 A ARG A 1 106 ? -45.30271 14.80039 15.32468  0.526 18.07914 ? 106 ARG A NH1 1 
ATOM   847  N  NH1 B ARG A 1 106 ? -45.60909 16.35862 14.81720  0.474 29.40207 ? 106 ARG A NH1 1 
ATOM   848  N  NH2 A ARG A 1 106 ? -44.83194 13.90140 17.37937  0.526 16.40431 ? 106 ARG A NH2 1 
ATOM   849  N  NH2 B ARG A 1 106 ? -45.33022 18.05839 13.30907  0.474 25.06741 ? 106 ARG A NH2 1 
ATOM   850  N  N   . ASN A 1 107 ? -37.77360 15.60382 18.05881  1.000 19.89153 ? 107 ASN A N   1 
ATOM   851  C  CA  . ASN A 1 107 ? -37.14556 14.91025 19.17270  1.000 20.29038 ? 107 ASN A CA  1 
ATOM   852  C  C   . ASN A 1 107 ? -35.79545 15.48916 19.56191  1.000 21.10751 ? 107 ASN A C   1 
ATOM   853  O  O   . ASN A 1 107 ? -35.33239 15.23436 20.67784  1.000 20.56694 ? 107 ASN A O   1 
ATOM   854  C  CB  . ASN A 1 107 ? -36.98926 13.42535 18.82265  1.000 18.75967 ? 107 ASN A CB  1 
ATOM   855  C  CG  . ASN A 1 107 ? -38.28711 12.67297 18.93795  1.000 26.22951 ? 107 ASN A CG  1 
ATOM   856  O  OD1 . ASN A 1 107 ? -39.06991 12.91066 19.84830  1.000 28.56631 ? 107 ASN A OD1 1 
ATOM   857  N  ND2 . ASN A 1 107 ? -38.54307 11.78517 17.98749  1.000 33.31795 ? 107 ASN A ND2 1 
ATOM   858  N  N   . TYR A 1 108 ? -35.14605 16.23776 18.67451  1.000 15.87824 ? 108 TYR A N   1 
ATOM   859  C  CA  . TYR A 1 108 ? -33.88207 16.88333 18.97994  1.000 17.70139 ? 108 TYR A CA  1 
ATOM   860  C  C   . TYR A 1 108 ? -33.87905 18.29828 18.43151  1.000 13.56761 ? 108 TYR A C   1 
ATOM   861  O  O   . TYR A 1 108 ? -34.68708 18.65766 17.57150  1.000 22.10090 ? 108 TYR A O   1 
ATOM   862  C  CB  . TYR A 1 108 ? -32.65974 16.10707 18.43481  1.000 17.94783 ? 108 TYR A CB  1 
ATOM   863  C  CG  . TYR A 1 108 ? -32.67273 14.63120 18.75684  1.000 24.99001 ? 108 TYR A CG  1 
ATOM   864  C  CD1 . TYR A 1 108 ? -33.63202 13.77331 18.23017  1.000 22.84127 ? 108 TYR A CD1 1 
ATOM   865  C  CD2 . TYR A 1 108 ? -31.82160 14.13861 19.73122  1.000 20.02089 ? 108 TYR A CD2 1 
ATOM   866  C  CE1 . TYR A 1 108 ? -33.66494 12.43266 18.58570  1.000 25.29150 ? 108 TYR A CE1 1 
ATOM   867  C  CE2 . TYR A 1 108 ? -31.84773 12.81576 20.10076  1.000 30.71210 ? 108 TYR A CE2 1 
ATOM   868  C  CZ  . TYR A 1 108 ? -32.77236 11.96669 19.53385  1.000 26.28973 ? 108 TYR A CZ  1 
ATOM   869  O  OH  . TYR A 1 108 ? -32.76805 10.65386 19.92208  1.000 30.32994 ? 108 TYR A OH  1 
ATOM   870  N  N   . SER A 1 109 ? -32.92475 19.08753 18.91199  1.000 14.82369 ? 109 SER A N   1 
ATOM   871  C  CA  . SER A 1 109 ? -32.76550 20.46105 18.45399  1.000 15.08865 ? 109 SER A CA  1 
ATOM   872  C  C   . SER A 1 109 ? -31.98514 20.47559 17.13872  1.000 17.36358 ? 109 SER A C   1 
ATOM   873  O  O   . SER A 1 109 ? -30.76862 20.25980 17.12478  1.000 16.66450 ? 109 SER A O   1 
ATOM   874  C  CB  . SER A 1 109 ? -32.05609 21.29242 19.51923  1.000 26.52363 ? 109 SER A CB  1 
ATOM   875  O  OG  . SER A 1 109 ? -32.12355 22.67117 19.19424  1.000 26.49944 ? 109 SER A OG  1 
ATOM   876  N  N   . VAL A 1 110 ? -32.68123 20.77320 16.03914  1.000 17.04225 ? 110 VAL A N   1 
ATOM   877  C  CA  . VAL A 1 110 ? -32.12962 20.72317 14.69032  1.000 14.47832 ? 110 VAL A CA  1 
ATOM   878  C  C   . VAL A 1 110 ? -32.09974 22.13484 14.11974  1.000 17.17396 ? 110 VAL A C   1 
ATOM   879  O  O   . VAL A 1 110 ? -33.06456 22.89528 14.24795  1.000 15.91931 ? 110 VAL A O   1 
ATOM   880  C  CB  . VAL A 1 110 ? -32.95702 19.78165 13.79077  1.000 13.48900 ? 110 VAL A CB  1 
ATOM   881  C  CG1 . VAL A 1 110 ? -32.52234 19.88310 12.32860  1.000 11.91556 ? 110 VAL A CG1 1 
ATOM   882  C  CG2 . VAL A 1 110 ? -32.82420 18.33802 14.29512  1.000 14.69838 ? 110 VAL A CG2 1 
ATOM   883  N  N   . ASP A 1 111 ? -31.00273 22.46347 13.45519  1.000 14.50969 ? 111 ASP A N   1 
ATOM   884  C  CA  . ASP A 1 111 ? -30.84068 23.73429 12.75508  1.000 13.62800 ? 111 ASP A CA  1 
ATOM   885  C  C   . ASP A 1 111 ? -31.58059 23.64930 11.42603  1.000 16.29747 ? 111 ASP A C   1 
ATOM   886  O  O   . ASP A 1 111 ? -31.10346 23.02358 10.47871  1.000 12.99694 ? 111 ASP A O   1 
ATOM   887  C  CB  . ASP A 1 111 ? -29.35693 24.01089 12.55487  1.000 20.61288 ? 111 ASP A CB  1 
ATOM   888  C  CG  . ASP A 1 111 ? -29.08890 25.34172 11.90136  1.000 24.36856 ? 111 ASP A CG  1 
ATOM   889  O  OD1 . ASP A 1 111 ? -30.01227 25.93057 11.29612  1.000 17.58593 ? 111 ASP A OD1 1 
ATOM   890  O  OD2 . ASP A 1 111 ? -27.92825 25.78464 11.98622  1.000 21.00569 ? 111 ASP A OD2 1 
ATOM   891  N  N   A SER A 1 112 ? -32.75391 24.28411 11.34689  0.415 15.08685 ? 112 SER A N   1 
ATOM   892  N  N   B SER A 1 112 ? -32.74766 24.29696 11.34092  0.585 15.04258 ? 112 SER A N   1 
ATOM   893  C  CA  A SER A 1 112 ? -33.57444 24.17508 10.14377  0.415 19.83603 ? 112 SER A CA  1 
ATOM   894  C  CA  B SER A 1 112 ? -33.56820 24.17664 10.13936  0.585 19.89488 ? 112 SER A CA  1 
ATOM   895  C  C   A SER A 1 112 ? -32.85424 24.67505 8.89734   0.415 15.57250 ? 112 SER A C   1 
ATOM   896  C  C   B SER A 1 112 ? -32.82872 24.64346 8.89335   0.585 15.53746 ? 112 SER A C   1 
ATOM   897  O  O   A SER A 1 112 ? -33.28732 24.36707 7.78072   0.415 17.23826 ? 112 SER A O   1 
ATOM   898  O  O   B SER A 1 112 ? -33.22613 24.28729 7.77732   0.585 17.24361 ? 112 SER A O   1 
ATOM   899  C  CB  A SER A 1 112 ? -34.89289 24.93920 10.31743  0.415 17.88752 ? 112 SER A CB  1 
ATOM   900  C  CB  B SER A 1 112 ? -34.86409 24.98238 10.27672  0.585 17.86022 ? 112 SER A CB  1 
ATOM   901  O  OG  A SER A 1 112 ? -35.64797 24.44069 11.40957  0.415 22.73567 ? 112 SER A OG  1 
ATOM   902  O  OG  B SER A 1 112 ? -34.60200 26.37497 10.28985  0.585 15.25342 ? 112 SER A OG  1 
ATOM   903  N  N   . ARG A 1 113 ? -31.77314 25.43525 9.05483   1.000 14.71205 ? 113 ARG A N   1 
ATOM   904  C  CA  . ARG A 1 113 ? -31.03457 25.94988 7.90726   1.000 18.51580 ? 113 ARG A CA  1 
ATOM   905  C  C   . ARG A 1 113 ? -29.89444 25.04341 7.48886   1.000 18.12215 ? 113 ARG A C   1 
ATOM   906  O  O   . ARG A 1 113 ? -29.22086 25.34363 6.50328   1.000 14.06805 ? 113 ARG A O   1 
ATOM   907  C  CB  . ARG A 1 113 ? -30.49313 27.34835 8.20500   1.000 21.96870 ? 113 ARG A CB  1 
ATOM   908  C  CG  . ARG A 1 113 ? -31.57933 28.40872 8.14942   1.000 25.54688 ? 113 ARG A CG  1 
ATOM   909  C  CD  . ARG A 1 113 ? -30.99878 29.80303 8.10368   1.000 25.16972 ? 113 ARG A CD  1 
ATOM   910  N  NE  . ARG A 1 113 ? -30.07783 30.00711 6.98592   1.000 24.38577 ? 113 ARG A NE  1 
ATOM   911  C  CZ  . ARG A 1 113 ? -28.86011 30.51609 7.12218   1.000 24.22034 ? 113 ARG A CZ  1 
ATOM   912  N  NH1 . ARG A 1 113 ? -28.37733 30.83500 8.31395   1.000 25.60245 ? 113 ARG A NH1 1 
ATOM   913  N  NH2 . ARG A 1 113 ? -28.10222 30.69341 6.04018   1.000 20.26327 ? 113 ARG A NH2 1 
ATOM   914  N  N   . ARG A 1 114 ? -29.66798 23.93844 8.20126   1.000 11.61679 ? 114 ARG A N   1 
ATOM   915  C  CA  . ARG A 1 114 ? -28.56043 23.05430 7.88770   1.000 14.09631 ? 114 ARG A CA  1 
ATOM   916  C  C   . ARG A 1 114 ? -29.06087 21.61250 7.93019   1.000 15.48849 ? 114 ARG A C   1 
ATOM   917  O  O   . ARG A 1 114 ? -28.61328 20.79072 8.71897   1.000 12.04972 ? 114 ARG A O   1 
ATOM   918  C  CB  . ARG A 1 114 ? -27.40323 23.32766 8.84069   1.000 12.19030 ? 114 ARG A CB  1 
ATOM   919  C  CG  . ARG A 1 114 ? -26.91082 24.77398 8.71777   1.000 20.32491 ? 114 ARG A CG  1 
ATOM   920  C  CD  . ARG A 1 114 ? -25.53079 24.92615 9.31421   1.000 15.92855 ? 114 ARG A CD  1 
ATOM   921  N  NE  . ARG A 1 114 ? -25.62933 24.85762 10.75796  1.000 18.37853 ? 114 ARG A NE  1 
ATOM   922  C  CZ  . ARG A 1 114 ? -24.59444 24.69890 11.56583  1.000 21.66843 ? 114 ARG A CZ  1 
ATOM   923  N  NH1 . ARG A 1 114 ? -23.35347 24.67359 11.10068  1.000 22.52435 ? 114 ARG A NH1 1 
ATOM   924  N  NH2 . ARG A 1 114 ? -24.81073 24.53871 12.86432  1.000 17.75449 ? 114 ARG A NH2 1 
ATOM   925  N  N   . VAL A 1 115 ? -30.04712 21.33098 7.08112   1.000 13.41623 ? 115 VAL A N   1 
ATOM   926  C  CA  . VAL A 1 115 ? -30.56512 19.98774 6.87111   1.000 11.12362 ? 115 VAL A CA  1 
ATOM   927  C  C   . VAL A 1 115 ? -30.28024 19.62340 5.42698   1.000 14.73728 ? 115 VAL A C   1 
ATOM   928  O  O   . VAL A 1 115 ? -30.60023 20.38826 4.50984   1.000 10.92406 ? 115 VAL A O   1 
ATOM   929  C  CB  . VAL A 1 115 ? -32.06486 19.87812 7.18811   1.000 9.49062  ? 115 VAL A CB  1 
ATOM   930  C  CG1 . VAL A 1 115 ? -32.55290 18.42234 6.91199   1.000 10.33439 ? 115 VAL A CG1 1 
ATOM   931  C  CG2 . VAL A 1 115 ? -32.32568 20.26618 8.65212   1.000 13.23371 ? 115 VAL A CG2 1 
ATOM   932  N  N   . TYR A 1 116 ? -29.65427 18.47476 5.23528   1.000 11.03794 ? 116 TYR A N   1 
ATOM   933  C  CA  . TYR A 1 116 ? -29.06990 18.07566 3.96926   1.000 13.12205 ? 116 TYR A CA  1 
ATOM   934  C  C   . TYR A 1 116 ? -29.50989 16.66427 3.63917   1.000 9.29285  ? 116 TYR A C   1 
ATOM   935  O  O   . TYR A 1 116 ? -29.83871 15.88133 4.53654   1.000 11.41265 ? 116 TYR A O   1 
ATOM   936  C  CB  . TYR A 1 116 ? -27.54256 18.11258 4.03678   1.000 9.90588  ? 116 TYR A CB  1 
ATOM   937  C  CG  . TYR A 1 116 ? -27.01367 19.42871 4.52273   1.000 10.34795 ? 116 TYR A CG  1 
ATOM   938  C  CD1 . TYR A 1 116 ? -26.85088 20.48505 3.64575   1.000 10.62025 ? 116 TYR A CD1 1 
ATOM   939  C  CD2 . TYR A 1 116 ? -26.70408 19.62207 5.86621   1.000 12.05828 ? 116 TYR A CD2 1 
ATOM   940  C  CE1 . TYR A 1 116 ? -26.38434 21.70479 4.07874   1.000 10.96830 ? 116 TYR A CE1 1 
ATOM   941  C  CE2 . TYR A 1 116 ? -26.23096 20.82967 6.32169   1.000 10.92126 ? 116 TYR A CE2 1 
ATOM   942  C  CZ  . TYR A 1 116 ? -26.06767 21.87216 5.41952   1.000 11.34555 ? 116 TYR A CZ  1 
ATOM   943  O  OH  . TYR A 1 116 ? -25.59628 23.09050 5.85280   1.000 16.53867 ? 116 TYR A OH  1 
ATOM   944  N  N   . ALA A 1 117 ? -29.50932 16.34511 2.34698   1.000 10.03808 ? 117 ALA A N   1 
ATOM   945  C  CA  . ALA A 1 117 ? -29.80059 15.00072 1.88285   1.000 9.23804  ? 117 ALA A CA  1 
ATOM   946  C  C   . ALA A 1 117 ? -28.65699 14.54307 0.99618   1.000 12.89998 ? 117 ALA A C   1 
ATOM   947  O  O   . ALA A 1 117 ? -28.31483 15.22507 0.02548   1.000 11.61976 ? 117 ALA A O   1 
ATOM   948  C  CB  . ALA A 1 117 ? -31.11977 14.95037 1.09924   1.000 9.31389  ? 117 ALA A CB  1 
ATOM   949  N  N   . ALA A 1 118 ? -28.09525 13.37866 1.30577   1.000 10.14885 ? 118 ALA A N   1 
ATOM   950  C  CA  . ALA A 1 118 ? -27.04422 12.79186 0.49385   1.000 8.14933  ? 118 ALA A CA  1 
ATOM   951  C  C   . ALA A 1 118 ? -27.31207 11.30443 0.33948   1.000 11.88233 ? 118 ALA A C   1 
ATOM   952  O  O   . ALA A 1 118 ? -27.97324 10.69039 1.18091   1.000 11.47112 ? 118 ALA A O   1 
ATOM   953  C  CB  . ALA A 1 118 ? -25.66368 13.00115 1.12028   1.000 9.96627  ? 118 ALA A CB  1 
ATOM   954  N  N   . GLY A 1 119 ? -26.79328 10.72811 -0.73617  1.000 7.71533  ? 119 GLY A N   1 
ATOM   955  C  CA  . GLY A 1 119 ? -26.92564 9.29148  -0.87346  1.000 10.54957 ? 119 GLY A CA  1 
ATOM   956  C  C   . GLY A 1 119 ? -26.10805 8.74454  -2.01424  1.000 11.49316 ? 119 GLY A C   1 
ATOM   957  O  O   . GLY A 1 119 ? -25.55657 9.48029  -2.83870  1.000 12.05345 ? 119 GLY A O   1 
ATOM   958  N  N   . LEU A 1 120 ? -26.04608 7.42039  -2.03669  1.000 10.95710 ? 120 LEU A N   1 
ATOM   959  C  CA  . LEU A 1 120 ? -25.35011 6.65064  -3.05159  1.000 12.05917 ? 120 LEU A CA  1 
ATOM   960  C  C   . LEU A 1 120 ? -26.36861 5.98263  -3.95777  1.000 14.53179 ? 120 LEU A C   1 
ATOM   961  O  O   . LEU A 1 120 ? -27.33643 5.39478  -3.46578  1.000 12.91175 ? 120 LEU A O   1 
ATOM   962  C  CB  . LEU A 1 120 ? -24.46781 5.57965  -2.40161  1.000 8.08184  ? 120 LEU A CB  1 
ATOM   963  C  CG  . LEU A 1 120 ? -23.83811 4.60561  -3.38480  1.000 10.14510 ? 120 LEU A CG  1 
ATOM   964  C  CD1 . LEU A 1 120 ? -22.84772 5.36300  -4.23024  1.000 11.91358 ? 120 LEU A CD1 1 
ATOM   965  C  CD2 . LEU A 1 120 ? -23.16954 3.50618  -2.59222  1.000 15.92822 ? 120 LEU A CD2 1 
ATOM   966  N  N   . SER A 1 121 ? -26.13643 6.06334  -5.26951  1.000 11.77772 ? 121 SER A N   1 
ATOM   967  C  CA  A SER A 1 121 ? -26.87556 5.28103  -6.26627  0.774 13.38839 ? 121 SER A CA  1 
ATOM   968  C  CA  B SER A 1 121 ? -26.87087 5.29348  -6.28299  0.226 13.39400 ? 121 SER A CA  1 
ATOM   969  C  C   . SER A 1 121 ? -28.35067 5.64448  -6.18451  1.000 11.18000 ? 121 SER A C   1 
ATOM   970  O  O   . SER A 1 121 ? -28.69706 6.82460  -6.37051  1.000 11.27199 ? 121 SER A O   1 
ATOM   971  C  CB  A SER A 1 121 ? -26.55416 3.79652  -6.04485  0.774 17.53235 ? 121 SER A CB  1 
ATOM   972  C  CB  B SER A 1 121 ? -26.52848 3.80686  -6.13359  0.226 17.35166 ? 121 SER A CB  1 
ATOM   973  O  OG  A SER A 1 121 ? -27.01859 2.99270  -7.11918  0.774 20.30979 ? 121 SER A OG  1 
ATOM   974  O  OG  B SER A 1 121 ? -26.98043 3.27891  -4.89981  0.226 14.25795 ? 121 SER A OG  1 
ATOM   975  N  N   . ALA A 1 122 ? -29.25153 4.69215  -5.93359  1.000 10.93646 ? 122 ALA A N   1 
ATOM   976  C  CA  . ALA A 1 122 ? -30.65855 5.04765  -5.79470  1.000 14.81118 ? 122 ALA A CA  1 
ATOM   977  C  C   . ALA A 1 122 ? -30.86728 6.13422  -4.74065  1.000 13.72895 ? 122 ALA A C   1 
ATOM   978  O  O   . ALA A 1 122 ? -31.78276 6.95971  -4.86947  1.000 9.68427  ? 122 ALA A O   1 
ATOM   979  C  CB  . ALA A 1 122 ? -31.47757 3.80048  -5.44855  1.000 12.44110 ? 122 ALA A CB  1 
ATOM   980  N  N   . GLY A 1 123 ? -30.04293 6.14178  -3.68737  1.000 9.45205  ? 123 GLY A N   1 
ATOM   981  C  CA  . GLY A 1 123 ? -30.13443 7.18564  -2.67214  1.000 7.79065  ? 123 GLY A CA  1 
ATOM   982  C  C   . GLY A 1 123 ? -29.58988 8.52742  -3.13979  1.000 12.43079 ? 123 GLY A C   1 
ATOM   983  O  O   . GLY A 1 123 ? -30.00398 9.57920  -2.64279  1.000 12.49050 ? 123 GLY A O   1 
ATOM   984  N  N   . GLY A 1 124 ? -28.64757 8.51619  -4.08596  1.000 9.57403  ? 124 GLY A N   1 
ATOM   985  C  CA  . GLY A 1 124 ? -28.26947 9.76072  -4.73597  1.000 9.73550  ? 124 GLY A CA  1 
ATOM   986  C  C   . GLY A 1 124 ? -29.37864 10.31313 -5.61435  1.000 12.25533 ? 124 GLY A C   1 
ATOM   987  O  O   . GLY A 1 124 ? -29.65211 11.51976 -5.60687  1.000 12.22715 ? 124 GLY A O   1 
ATOM   988  N  N   . ALA A 1 125 ? -30.02575 9.44124  -6.39106  1.000 10.38893 ? 125 ALA A N   1 
ATOM   989  C  CA  . ALA A 1 125 ? -31.19172 9.84848  -7.17375  1.000 8.16071  ? 125 ALA A CA  1 
ATOM   990  C  C   . ALA A 1 125 ? -32.33374 10.34055 -6.28133  1.000 9.11228  ? 125 ALA A C   1 
ATOM   991  O  O   . ALA A 1 125 ? -33.02323 11.30358 -6.63513  1.000 11.06845 ? 125 ALA A O   1 
ATOM   992  C  CB  . ALA A 1 125 ? -31.66414 8.68443  -8.05179  1.000 8.23568  ? 125 ALA A CB  1 
ATOM   993  N  N   . MET A 1 126 ? -32.59650 9.65191  -5.15791  1.000 12.35947 ? 126 MET A N   1 
ATOM   994  C  CA  . MET A 1 126 ? -33.54767 10.15403 -4.15363  1.000 9.46486  ? 126 MET A CA  1 
ATOM   995  C  C   . MET A 1 126 ? -33.16558 11.47393 -3.53362  1.000 11.27409 ? 126 MET A C   1 
ATOM   996  O  O   . MET A 1 126 ? -34.04380 12.28574 -3.21788  1.000 10.66019 ? 126 MET A O   1 
ATOM   997  C  CB  . MET A 1 126 ? -33.80953 9.09840  -3.07222  1.000 7.46964  ? 126 MET A CB  1 
ATOM   998  C  CG  . MET A 1 126 ? -35.17571 9.26221  -2.34271  1.000 8.66635  ? 126 MET A CG  1 
ATOM   999  S  SD  . MET A 1 126 ? -36.65577 9.74474  -3.21858  1.000 12.76933 ? 126 MET A SD  1 
ATOM   1000 C  CE  . MET A 1 126 ? -37.05349 8.12539  -4.08907  1.000 10.81708 ? 126 MET A CE  1 
ATOM   1001 N  N   . SER A 1 127 ? -31.86931 11.70269 -3.31415  1.000 10.97733 ? 127 SER A N   1 
ATOM   1002 C  CA  . SER A 1 127 ? -31.45523 12.99677 -2.79529  1.000 11.23131 ? 127 SER A CA  1 
ATOM   1003 C  C   . SER A 1 127 ? -31.78325 14.09595 -3.80033  1.000 11.65785 ? 127 SER A C   1 
ATOM   1004 O  O   . SER A 1 127 ? -32.23423 15.18168 -3.41347  1.000 10.22863 ? 127 SER A O   1 
ATOM   1005 C  CB  . SER A 1 127 ? -29.95781 12.98168 -2.44574  1.000 11.12680 ? 127 SER A CB  1 
ATOM   1006 O  OG  . SER A 1 127 ? -29.68532 12.07618 -1.38553  1.000 12.61809 ? 127 SER A OG  1 
ATOM   1007 N  N   . VAL A 1 128 ? -31.58166 13.82392 -5.09938  1.000 11.15697 ? 128 VAL A N   1 
ATOM   1008 C  CA  . VAL A 1 128 ? -32.04932 14.73827 -6.14417  1.000 10.36059 ? 128 VAL A CA  1 
ATOM   1009 C  C   . VAL A 1 128 ? -33.53810 15.00418 -5.97202  1.000 10.20525 ? 128 VAL A C   1 
ATOM   1010 O  O   . VAL A 1 128 ? -33.99532 16.15500 -5.98723  1.000 9.32382  ? 128 VAL A O   1 
ATOM   1011 C  CB  . VAL A 1 128 ? -31.73753 14.16684 -7.54330  1.000 11.22324 ? 128 VAL A CB  1 
ATOM   1012 C  CG1 . VAL A 1 128 ? -32.58141 14.84916 -8.62795  1.000 9.78258  ? 128 VAL A CG1 1 
ATOM   1013 C  CG2 . VAL A 1 128 ? -30.21809 14.27373 -7.85846  1.000 12.61930 ? 128 VAL A CG2 1 
ATOM   1014 N  N   . ILE A 1 129 ? -34.31511 13.94006 -5.78466  1.000 9.51803  ? 129 ILE A N   1 
ATOM   1015 C  CA  . ILE A 1 129 ? -35.75619 14.09594 -5.64624  1.000 9.80729  ? 129 ILE A CA  1 
ATOM   1016 C  C   . ILE A 1 129 ? -36.09020 14.91399 -4.40764  1.000 9.68775  ? 129 ILE A C   1 
ATOM   1017 O  O   . ILE A 1 129 ? -37.00002 15.75187 -4.42997  1.000 10.57373 ? 129 ILE A O   1 
ATOM   1018 C  CB  . ILE A 1 129 ? -36.43343 12.71736 -5.62055  1.000 10.01833 ? 129 ILE A CB  1 
ATOM   1019 C  CG1 . ILE A 1 129 ? -36.35986 12.06176 -7.01273  1.000 9.57705  ? 129 ILE A CG1 1 
ATOM   1020 C  CG2 . ILE A 1 129 ? -37.88442 12.85519 -5.14228  1.000 10.36409 ? 129 ILE A CG2 1 
ATOM   1021 C  CD1 . ILE A 1 129 ? -36.72337 10.53764 -7.03307  1.000 9.25506  ? 129 ILE A CD1 1 
ATOM   1022 N  N   . MET A 1 130 ? -35.36181 14.69457 -3.30831  1.000 9.52001  ? 130 MET A N   1 
ATOM   1023 C  CA  . MET A 1 130 ? -35.62888 15.48638 -2.10675  1.000 12.02866 ? 130 MET A CA  1 
ATOM   1024 C  C   . MET A 1 130 ? -35.37255 16.97070 -2.33419  1.000 12.11819 ? 130 MET A C   1 
ATOM   1025 O  O   . MET A 1 130 ? -36.10305 17.81692 -1.80191  1.000 11.42169 ? 130 MET A O   1 
ATOM   1026 C  CB  . MET A 1 130 ? -34.80183 14.99197 -0.91180  1.000 6.90989  ? 130 MET A CB  1 
ATOM   1027 C  CG  . MET A 1 130 ? -35.04501 13.52509 -0.56648  1.000 9.72657  ? 130 MET A CG  1 
ATOM   1028 S  SD  . MET A 1 130 ? -36.81715 13.17904 -0.41318  1.000 12.06075 ? 130 MET A SD  1 
ATOM   1029 C  CE  . MET A 1 130 ? -37.31727 14.33046 0.85150   1.000 10.04590 ? 130 MET A CE  1 
ATOM   1030 N  N   . GLY A 1 131 ? -34.31020 17.30843 -3.07198  1.000 12.03121 ? 131 GLY A N   1 
ATOM   1031 C  CA  . GLY A 1 131 ? -34.04872 18.71186 -3.35265  1.000 8.56101  ? 131 GLY A CA  1 
ATOM   1032 C  C   . GLY A 1 131 ? -35.13793 19.34280 -4.20129  1.000 12.23527 ? 131 GLY A C   1 
ATOM   1033 O  O   . GLY A 1 131 ? -35.50546 20.50582 -4.00079  1.000 11.78256 ? 131 GLY A O   1 
ATOM   1034 N  N   . ALA A 1 132 ? -35.67950 18.57883 -5.15385  1.000 10.28266 ? 132 ALA A N   1 
ATOM   1035 C  CA  . ALA A 1 132 ? -36.72430 19.10676 -6.02499  1.000 12.25639 ? 132 ALA A CA  1 
ATOM   1036 C  C   . ALA A 1 132 ? -38.06469 19.20565 -5.31584  1.000 17.03622 ? 132 ALA A C   1 
ATOM   1037 O  O   . ALA A 1 132 ? -38.86538 20.09312 -5.63633  1.000 14.34158 ? 132 ALA A O   1 
ATOM   1038 C  CB  . ALA A 1 132 ? -36.88275 18.22263 -7.25774  1.000 11.33046 ? 132 ALA A CB  1 
ATOM   1039 N  N   . THR A 1 133 ? -38.34489 18.30370 -4.37562  1.000 11.44356 ? 133 THR A N   1 
ATOM   1040 C  CA  . THR A 1 133 ? -39.67310 18.25809 -3.77637  1.000 11.31646 ? 133 THR A CA  1 
ATOM   1041 C  C   . THR A 1 133 ? -39.75605 18.97721 -2.44497  1.000 12.12352 ? 133 THR A C   1 
ATOM   1042 O  O   . THR A 1 133 ? -40.82263 19.50396 -2.10924  1.000 11.30815 ? 133 THR A O   1 
ATOM   1043 C  CB  . THR A 1 133 ? -40.14473 16.80511 -3.60511  1.000 11.17635 ? 133 THR A CB  1 
ATOM   1044 O  OG1 . THR A 1 133 ? -39.19210 16.05684 -2.82932  1.000 11.65976 ? 133 THR A OG1 1 
ATOM   1045 C  CG2 . THR A 1 133 ? -40.34357 16.14629 -4.97396  1.000 13.87449 ? 133 THR A CG2 1 
ATOM   1046 N  N   . TYR A 1 134 ? -38.65251 19.03828 -1.69156  1.000 12.26333 ? 134 TYR A N   1 
ATOM   1047 C  CA  . TYR A 1 134 ? -38.63918 19.67449 -0.37308  1.000 9.42148  ? 134 TYR A CA  1 
ATOM   1048 C  C   . TYR A 1 134 ? -37.46790 20.64825 -0.24635  1.000 11.62876 ? 134 TYR A C   1 
ATOM   1049 O  O   . TYR A 1 134 ? -36.68905 20.58274 0.70460   1.000 10.18496 ? 134 TYR A O   1 
ATOM   1050 C  CB  . TYR A 1 134 ? -38.59099 18.62192 0.73695   1.000 13.11342 ? 134 TYR A CB  1 
ATOM   1051 C  CG  . TYR A 1 134 ? -39.88153 17.83688 0.88325   1.000 15.53933 ? 134 TYR A CG  1 
ATOM   1052 C  CD1 . TYR A 1 134 ? -40.09004 16.66180 0.16439   1.000 12.93821 ? 134 TYR A CD1 1 
ATOM   1053 C  CD2 . TYR A 1 134 ? -40.89272 18.27861 1.72874   1.000 13.67925 ? 134 TYR A CD2 1 
ATOM   1054 C  CE1 . TYR A 1 134 ? -41.27966 15.93144 0.29735   1.000 8.96982  ? 134 TYR A CE1 1 
ATOM   1055 C  CE2 . TYR A 1 134 ? -42.08030 17.57224 1.86293   1.000 9.09626  ? 134 TYR A CE2 1 
ATOM   1056 C  CZ  . TYR A 1 134 ? -42.27057 16.40346 1.14528   1.000 12.75007 ? 134 TYR A CZ  1 
ATOM   1057 O  OH  . TYR A 1 134 ? -43.45080 15.70124 1.26081   1.000 15.17181 ? 134 TYR A OH  1 
ATOM   1058 N  N   . PRO A 1 135 ? -37.32661 21.58406 -1.18834  1.000 10.24021 ? 135 PRO A N   1 
ATOM   1059 C  CA  . PRO A 1 135 ? -36.25180 22.58205 -1.07218  1.000 12.26558 ? 135 PRO A CA  1 
ATOM   1060 C  C   . PRO A 1 135 ? -36.41697 23.49780 0.12274   1.000 13.00969 ? 135 PRO A C   1 
ATOM   1061 O  O   . PRO A 1 135 ? -35.44167 24.12098 0.54740   1.000 14.12448 ? 135 PRO A O   1 
ATOM   1062 C  CB  . PRO A 1 135 ? -36.35483 23.35970 -2.38990  1.000 10.22559 ? 135 PRO A CB  1 
ATOM   1063 C  CG  . PRO A 1 135 ? -37.82830 23.27354 -2.72853  1.000 11.87878 ? 135 PRO A CG  1 
ATOM   1064 C  CD  . PRO A 1 135 ? -38.25104 21.88126 -2.29510  1.000 10.63454 ? 135 PRO A CD  1 
ATOM   1065 N  N   . ASP A 1 136 ? -37.62723 23.60750 0.66568   1.000 12.52144 ? 136 ASP A N   1 
ATOM   1066 C  CA  . ASP A 1 136 ? -37.83766 24.32791 1.91637   1.000 13.78607 ? 136 ASP A CA  1 
ATOM   1067 C  C   . ASP A 1 136 ? -37.19378 23.61809 3.09481   1.000 14.69297 ? 136 ASP A C   1 
ATOM   1068 O  O   . ASP A 1 136 ? -36.95295 24.25057 4.12974   1.000 14.89482 ? 136 ASP A O   1 
ATOM   1069 C  CB  . ASP A 1 136 ? -39.34132 24.49728 2.17638   1.000 12.64942 ? 136 ASP A CB  1 
ATOM   1070 C  CG  . ASP A 1 136 ? -40.10619 23.16958 2.11719   1.000 15.69357 ? 136 ASP A CG  1 
ATOM   1071 O  OD1 . ASP A 1 136 ? -39.80793 22.35804 1.21716   1.000 16.15200 ? 136 ASP A OD1 1 
ATOM   1072 O  OD2 . ASP A 1 136 ? -41.04347 22.94908 2.93631   1.000 13.64943 ? 136 ASP A OD2 1 
ATOM   1073 N  N   . VAL A 1 137 ? -36.91842 22.32647 2.96437   1.000 12.15475 ? 137 VAL A N   1 
ATOM   1074 C  CA  . VAL A 1 137 ? -36.33603 21.53232 4.04911   1.000 9.24740  ? 137 VAL A CA  1 
ATOM   1075 C  C   . VAL A 1 137 ? -34.83051 21.36450 3.88915   1.000 14.07215 ? 137 VAL A C   1 
ATOM   1076 O  O   . VAL A 1 137 ? -34.08066 21.49599 4.85524   1.000 14.21042 ? 137 VAL A O   1 
ATOM   1077 C  CB  . VAL A 1 137 ? -37.03132 20.15566 4.13817   1.000 11.97586 ? 137 VAL A CB  1 
ATOM   1078 C  CG1 . VAL A 1 137 ? -36.33641 19.28561 5.18977   1.000 11.76592 ? 137 VAL A CG1 1 
ATOM   1079 C  CG2 . VAL A 1 137 ? -38.52383 20.32195 4.44993   1.000 10.91228 ? 137 VAL A CG2 1 
ATOM   1080 N  N   . PHE A 1 138 ? -34.37250 21.05254 2.67905   1.000 9.16556  ? 138 PHE A N   1 
ATOM   1081 C  CA  . PHE A 1 138 ? -33.00018 20.60948 2.45113   1.000 12.20639 ? 138 PHE A CA  1 
ATOM   1082 C  C   . PHE A 1 138 ? -32.16910 21.75573 1.90345   1.000 12.39650 ? 138 PHE A C   1 
ATOM   1083 O  O   . PHE A 1 138 ? -32.44868 22.26898 0.81298   1.000 12.51298 ? 138 PHE A O   1 
ATOM   1084 C  CB  . PHE A 1 138 ? -33.00275 19.40059 1.51757   1.000 11.93085 ? 138 PHE A CB  1 
ATOM   1085 C  CG  . PHE A 1 138 ? -33.65806 18.21148 2.14078   1.000 13.02719 ? 138 PHE A CG  1 
ATOM   1086 C  CD1 . PHE A 1 138 ? -32.94648 17.41799 3.03792   1.000 10.82442 ? 138 PHE A CD1 1 
ATOM   1087 C  CD2 . PHE A 1 138 ? -35.00294 17.95659 1.93866   1.000 10.31088 ? 138 PHE A CD2 1 
ATOM   1088 C  CE1 . PHE A 1 138 ? -33.55557 16.34921 3.67529   1.000 11.13123 ? 138 PHE A CE1 1 
ATOM   1089 C  CE2 . PHE A 1 138 ? -35.61257 16.89059 2.56230   1.000 14.22866 ? 138 PHE A CE2 1 
ATOM   1090 C  CZ  . PHE A 1 138 ? -34.88714 16.07529 3.42246   1.000 12.14185 ? 138 PHE A CZ  1 
ATOM   1091 N  N   . ALA A 1 139 ? -31.16026 22.16150 2.67421   1.000 14.80705 ? 139 ALA A N   1 
ATOM   1092 C  CA  . ALA A 1 139 ? -30.33985 23.29864 2.28266   1.000 12.54173 ? 139 ALA A CA  1 
ATOM   1093 C  C   . ALA A 1 139 ? -29.55980 22.99769 1.01466   1.000 14.37034 ? 139 ALA A C   1 
ATOM   1094 O  O   . ALA A 1 139 ? -29.42250 23.86507 0.14005   1.000 13.92137 ? 139 ALA A O   1 
ATOM   1095 C  CB  . ALA A 1 139 ? -29.39037 23.65784 3.41572   1.000 13.34735 ? 139 ALA A CB  1 
ATOM   1096 N  N   . ALA A 1 140 ? -29.03447 21.77668 0.90793   1.000 10.33457 ? 140 ALA A N   1 
ATOM   1097 C  CA  . ALA A 1 140 ? -28.18776 21.37033 -0.20200  1.000 10.79049 ? 140 ALA A CA  1 
ATOM   1098 C  C   . ALA A 1 140 ? -28.19889 19.84584 -0.24571  1.000 10.10806 ? 140 ALA A C   1 
ATOM   1099 O  O   . ALA A 1 140 ? -28.60494 19.18778 0.71778   1.000 9.69822  ? 140 ALA A O   1 
ATOM   1100 C  CB  . ALA A 1 140 ? -26.76395 21.91812 -0.04663  1.000 6.76934  ? 140 ALA A CB  1 
ATOM   1101 N  N   . ILE A 1 141 ? -27.76356 19.28743 -1.37489  1.000 9.96717  ? 141 ILE A N   1 
ATOM   1102 C  CA  . ILE A 1 141 ? -27.80959 17.84054 -1.56367  1.000 8.58921  ? 141 ILE A CA  1 
ATOM   1103 C  C   . ILE A 1 141 ? -26.47904 17.31809 -2.09019  1.000 13.58770 ? 141 ILE A C   1 
ATOM   1104 O  O   . ILE A 1 141 ? -25.74421 18.00631 -2.80448  1.000 11.68394 ? 141 ILE A O   1 
ATOM   1105 C  CB  . ILE A 1 141 ? -28.96037 17.42140 -2.50975  1.000 11.01780 ? 141 ILE A CB  1 
ATOM   1106 C  CG1 . ILE A 1 141 ? -28.76116 18.03563 -3.89086  1.000 10.28656 ? 141 ILE A CG1 1 
ATOM   1107 C  CG2 . ILE A 1 141 ? -30.30924 17.82080 -1.91184  1.000 13.80141 ? 141 ILE A CG2 1 
ATOM   1108 C  CD1 . ILE A 1 141 ? -29.72023 17.48343 -4.92731  1.000 9.39062  ? 141 ILE A CD1 1 
ATOM   1109 N  N   . GLY A 1 142 ? -26.18896 16.06748 -1.75566  1.000 9.33869  ? 142 GLY A N   1 
ATOM   1110 C  CA  . GLY A 1 142 ? -25.00513 15.39517 -2.25900  1.000 7.49469  ? 142 GLY A CA  1 
ATOM   1111 C  C   . GLY A 1 142 ? -25.39039 14.14690 -3.02057  1.000 10.50368 ? 142 GLY A C   1 
ATOM   1112 O  O   . GLY A 1 142 ? -26.14905 13.30720 -2.51525  1.000 11.80518 ? 142 GLY A O   1 
ATOM   1113 N  N   . VAL A 1 143 ? -24.87510 13.98942 -4.23134  1.000 10.06295 ? 143 VAL A N   1 
ATOM   1114 C  CA  . VAL A 1 143 ? -25.36238 12.95179 -5.13708  1.000 10.78315 ? 143 VAL A CA  1 
ATOM   1115 C  C   . VAL A 1 143 ? -24.18764 12.04974 -5.48691  1.000 12.33333 ? 143 VAL A C   1 
ATOM   1116 O  O   . VAL A 1 143 ? -23.34916 12.38818 -6.33995  1.000 13.66347 ? 143 VAL A O   1 
ATOM   1117 C  CB  . VAL A 1 143 ? -26.01503 13.53655 -6.38986  1.000 9.06924  ? 143 VAL A CB  1 
ATOM   1118 C  CG1 . VAL A 1 143 ? -26.54937 12.39653 -7.25757  1.000 9.12293  ? 143 VAL A CG1 1 
ATOM   1119 C  CG2 . VAL A 1 143 ? -27.15075 14.51065 -6.00596  1.000 9.74229  ? 143 VAL A CG2 1 
ATOM   1120 N  N   . GLY A 1 144 ? -24.10831 10.90771 -4.81443  1.000 8.53446  ? 144 GLY A N   1 
ATOM   1121 C  CA  . GLY A 1 144 ? -23.04305 9.96701  -5.10160  1.000 9.47069  ? 144 GLY A CA  1 
ATOM   1122 C  C   . GLY A 1 144 ? -23.50483 8.94756  -6.12594  1.000 12.50761 ? 144 GLY A C   1 
ATOM   1123 O  O   . GLY A 1 144 ? -24.35817 8.10377  -5.83922  1.000 14.04578 ? 144 GLY A O   1 
ATOM   1124 N  N   . SER A 1 145 ? -22.98340 9.05228  -7.33981  1.000 11.44405 ? 145 SER A N   1 
ATOM   1125 C  CA  . SER A 1 145 ? -23.28251 8.09786  -8.40564  1.000 9.08909  ? 145 SER A CA  1 
ATOM   1126 C  C   . SER A 1 145 ? -24.79387 7.95843  -8.61734  1.000 11.96426 ? 145 SER A C   1 
ATOM   1127 O  O   . SER A 1 145 ? -25.34365 6.85479  -8.62340  1.000 12.84144 ? 145 SER A O   1 
ATOM   1128 C  CB  . SER A 1 145 ? -22.62863 6.75066  -8.09975  1.000 9.82483  ? 145 SER A CB  1 
ATOM   1129 O  OG  . SER A 1 145 ? -21.27120 6.96045  -7.68209  1.000 13.78457 ? 145 SER A OG  1 
ATOM   1130 N  N   . GLY A 1 146 ? -25.46722 9.10113  -8.80562  1.000 11.73413 ? 146 GLY A N   1 
ATOM   1131 C  CA  . GLY A 1 146 ? -26.90981 9.16353  -8.91203  1.000 9.80116  ? 146 GLY A CA  1 
ATOM   1132 C  C   . GLY A 1 146 ? -27.39322 9.48194  -10.31656 1.000 9.95539  ? 146 GLY A C   1 
ATOM   1133 O  O   . GLY A 1 146 ? -26.65802 9.34452  -11.30392 1.000 12.46832 ? 146 GLY A O   1 
ATOM   1134 N  N   . LEU A 1 147 ? -28.65703 9.92572  -10.40716 1.000 10.61688 ? 147 LEU A N   1 
ATOM   1135 C  CA  . LEU A 1 147 ? -29.27755 10.26612 -11.68826 1.000 6.68671  ? 147 LEU A CA  1 
ATOM   1136 C  C   . LEU A 1 147 ? -30.12201 11.52511 -11.54653 1.000 10.42361 ? 147 LEU A C   1 
ATOM   1137 O  O   . LEU A 1 147 ? -30.57493 11.87839 -10.45559 1.000 10.52461 ? 147 LEU A O   1 
ATOM   1138 C  CB  . LEU A 1 147 ? -30.16779 9.13135  -12.22151 1.000 7.00396  ? 147 LEU A CB  1 
ATOM   1139 C  CG  . LEU A 1 147 ? -29.51610 7.76186  -12.44345 1.000 8.26270  ? 147 LEU A CG  1 
ATOM   1140 C  CD1 . LEU A 1 147 ? -29.67025 6.92555  -11.19301 1.000 7.90083  ? 147 LEU A CD1 1 
ATOM   1141 C  CD2 . LEU A 1 147 ? -30.14719 7.03755  -13.63979 1.000 12.64005 ? 147 LEU A CD2 1 
ATOM   1142 N  N   . GLU A 1 148 ? -30.33579 12.19788 -12.67585 1.000 9.48604  ? 148 GLU A N   1 
ATOM   1143 C  CA  . GLU A 1 148 ? -31.06036 13.46004 -12.68023 1.000 9.22310  ? 148 GLU A CA  1 
ATOM   1144 C  C   . GLU A 1 148 ? -32.52681 13.24889 -12.30169 1.000 12.39617 ? 148 GLU A C   1 
ATOM   1145 O  O   . GLU A 1 148 ? -33.05798 12.13115 -12.29315 1.000 12.66490 ? 148 GLU A O   1 
ATOM   1146 C  CB  . GLU A 1 148 ? -30.98129 14.12030 -14.05936 1.000 10.99759 ? 148 GLU A CB  1 
ATOM   1147 C  CG  . GLU A 1 148 ? -31.88888 13.40679 -15.07199 1.000 11.33206 ? 148 GLU A CG  1 
ATOM   1148 C  CD  . GLU A 1 148 ? -31.76059 13.94351 -16.46800 1.000 17.30138 ? 148 GLU A CD  1 
ATOM   1149 O  OE1 . GLU A 1 148 ? -31.19540 15.04767 -16.62826 1.000 12.85459 ? 148 GLU A OE1 1 
ATOM   1150 O  OE2 . GLU A 1 148 ? -32.25025 13.26382 -17.39494 1.000 12.73612 ? 148 GLU A OE2 1 
ATOM   1151 N  N   . TYR A 1 149 ? -33.19302 14.35546 -11.98574 1.000 16.26233 ? 149 TYR A N   1 
ATOM   1152 C  CA  . TYR A 1 149 ? -34.59996 14.27616 -11.61319 1.000 12.87748 ? 149 TYR A CA  1 
ATOM   1153 C  C   . TYR A 1 149 ? -35.40858 13.62915 -12.73399 1.000 7.30178  ? 149 TYR A C   1 
ATOM   1154 O  O   . TYR A 1 149 ? -35.30947 14.02661 -13.89746 1.000 12.90000 ? 149 TYR A O   1 
ATOM   1155 C  CB  . TYR A 1 149 ? -35.13751 15.67155 -11.30800 1.000 8.00211  ? 149 TYR A CB  1 
ATOM   1156 C  CG  . TYR A 1 149 ? -36.57988 15.65951 -10.86053 1.000 9.89022  ? 149 TYR A CG  1 
ATOM   1157 C  CD1 . TYR A 1 149 ? -36.93891 15.06332 -9.65224  1.000 10.86188 ? 149 TYR A CD1 1 
ATOM   1158 C  CD2 . TYR A 1 149 ? -37.57540 16.25745 -11.62171 1.000 7.80030  ? 149 TYR A CD2 1 
ATOM   1159 C  CE1 . TYR A 1 149 ? -38.25885 15.04884 -9.22489  1.000 10.57958 ? 149 TYR A CE1 1 
ATOM   1160 C  CE2 . TYR A 1 149 ? -38.90358 16.23463 -11.20355 1.000 9.31742  ? 149 TYR A CE2 1 
ATOM   1161 C  CZ  . TYR A 1 149 ? -39.23395 15.63806 -10.01298 1.000 11.84238 ? 149 TYR A CZ  1 
ATOM   1162 O  OH  . TYR A 1 149 ? -40.54957 15.63996 -9.60337  1.000 13.27092 ? 149 TYR A OH  1 
ATOM   1163 N  N   . LYS A 1 150 ? -36.21002 12.62472 -12.37899 1.000 11.04853 ? 150 LYS A N   1 
ATOM   1164 C  CA  . LYS A 1 150 ? -37.03860 11.90520 -13.34979 1.000 13.79861 ? 150 LYS A CA  1 
ATOM   1165 C  C   . LYS A 1 150 ? -36.21998 11.38152 -14.53079 1.000 13.02942 ? 150 LYS A C   1 
ATOM   1166 O  O   . LYS A 1 150 ? -36.66918 11.39386 -15.68467 1.000 15.67632 ? 150 LYS A O   1 
ATOM   1167 C  CB  . LYS A 1 150 ? -38.20004 12.77897 -13.83191 1.000 15.49100 ? 150 LYS A CB  1 
ATOM   1168 C  CG  . LYS A 1 150 ? -39.35960 12.87413 -12.82171 1.000 12.15449 ? 150 LYS A CG  1 
ATOM   1169 C  CD  . LYS A 1 150 ? -40.49663 13.74631 -13.35088 1.000 17.36364 ? 150 LYS A CD  1 
ATOM   1170 C  CE  . LYS A 1 150 ? -41.64592 13.84865 -12.35077 1.000 19.32414 ? 150 LYS A CE  1 
ATOM   1171 N  NZ  . LYS A 1 150 ? -42.37592 12.56048 -12.19444 1.000 19.60698 ? 150 LYS A NZ  1 
ATOM   1172 N  N   . ALA A 1 151 ? -35.00829 10.88825 -14.24269 1.000 14.00313 ? 151 ALA A N   1 
ATOM   1173 C  CA  . ALA A 1 151 ? -34.23377 10.22711 -15.28976 1.000 12.85220 ? 151 ALA A CA  1 
ATOM   1174 C  C   . ALA A 1 151 ? -35.03407 9.08894  -15.90573 1.000 18.95914 ? 151 ALA A C   1 
ATOM   1175 O  O   . ALA A 1 151 ? -34.91769 8.82862  -17.11100 1.000 13.66057 ? 151 ALA A O   1 
ATOM   1176 C  CB  . ALA A 1 151 ? -32.89477 9.73156  -14.73544 1.000 10.67053 ? 151 ALA A CB  1 
ATOM   1177 N  N   . ALA A 1 152 ? -35.86967 8.43341  -15.09768 1.000 11.73184 ? 152 ALA A N   1 
ATOM   1178 C  CA  . ALA A 1 152 ? -36.89063 7.49876  -15.54130 1.000 15.83918 ? 152 ALA A CA  1 
ATOM   1179 C  C   . ALA A 1 152 ? -38.15129 7.80296  -14.74361 1.000 15.83998 ? 152 ALA A C   1 
ATOM   1180 O  O   . ALA A 1 152 ? -38.06924 8.32195  -13.62806 1.000 17.13191 ? 152 ALA A O   1 
ATOM   1181 C  CB  . ALA A 1 152 ? -36.46400 6.04914  -15.32337 1.000 15.30794 ? 152 ALA A CB  1 
ATOM   1182 N  N   . THR A 1 153 ? -39.31923 7.49717  -15.31614 1.000 16.99045 ? 153 THR A N   1 
ATOM   1183 C  CA  . THR A 1 153 ? -40.58553 7.68225  -14.60124 1.000 17.40350 ? 153 THR A CA  1 
ATOM   1184 C  C   . THR A 1 153 ? -41.36438 6.38375  -14.46297 1.000 26.85649 ? 153 THR A C   1 
ATOM   1185 O  O   . THR A 1 153 ? -42.46546 6.39119  -13.89838 1.000 26.87639 ? 153 THR A O   1 
ATOM   1186 C  CB  . THR A 1 153 ? -41.48942 8.71017  -15.29262 1.000 16.30855 ? 153 THR A CB  1 
ATOM   1187 O  OG1 . THR A 1 153 ? -41.64515 8.35359  -16.66405 1.000 18.78802 ? 153 THR A OG1 1 
ATOM   1188 C  CG2 . THR A 1 153 ? -40.86900 10.10528 -15.19791 1.000 23.18103 ? 153 THR A CG2 1 
ATOM   1189 N  N   . SER A 1 154 ? -40.84549 5.28564  -14.99297 1.000 18.86693 ? 154 SER A N   1 
ATOM   1190 C  CA  . SER A 1 154 ? -41.34685 3.95788  -14.68005 1.000 35.01606 ? 154 SER A CA  1 
ATOM   1191 C  C   . SER A 1 154 ? -40.15198 3.05077  -14.44658 1.000 25.13591 ? 154 SER A C   1 
ATOM   1192 O  O   . SER A 1 154 ? -39.03046 3.34747  -14.86665 1.000 24.30077 ? 154 SER A O   1 
ATOM   1193 C  CB  . SER A 1 154 ? -42.23613 3.38285  -15.79733 1.000 35.67087 ? 154 SER A CB  1 
ATOM   1194 O  OG  . SER A 1 154 ? -43.15460 4.35123  -16.28085 1.000 44.04341 ? 154 SER A OG  1 
ATOM   1195 N  N   . MET A 1 155 ? -40.39630 1.92847  -13.76838 1.000 24.07595 ? 155 MET A N   1 
ATOM   1196 C  CA  . MET A 1 155 ? -39.33542 0.93912  -13.65477 1.000 28.60472 ? 155 MET A CA  1 
ATOM   1197 C  C   . MET A 1 155 ? -38.92535 0.42427  -15.02908 1.000 32.66076 ? 155 MET A C   1 
ATOM   1198 O  O   . MET A 1 155 ? -37.75884 0.07943  -15.23951 1.000 28.18538 ? 155 MET A O   1 
ATOM   1199 C  CB  . MET A 1 155 ? -39.78119 -0.20473 -12.74675 1.000 42.60004 ? 155 MET A CB  1 
ATOM   1200 C  CG  . MET A 1 155 ? -38.94401 -1.45736 -12.86319 1.000 43.49587 ? 155 MET A CG  1 
ATOM   1201 S  SD  . MET A 1 155 ? -39.46730 -2.65654 -11.62964 1.000 76.12872 ? 155 MET A SD  1 
ATOM   1202 C  CE  . MET A 1 155 ? -41.21443 -2.77685 -12.03779 1.000 52.19470 ? 155 MET A CE  1 
ATOM   1203 N  N   . THR A 1 156 ? -39.85647 0.41857  -15.99062 1.000 34.75295 ? 156 THR A N   1 
ATOM   1204 C  CA  . THR A 1 156 ? -39.54978 -0.11254 -17.31570 1.000 37.72327 ? 156 THR A CA  1 
ATOM   1205 C  C   . THR A 1 156 ? -38.42350 0.66339  -18.00713 1.000 39.68681 ? 156 THR A C   1 
ATOM   1206 O  O   . THR A 1 156 ? -37.68277 0.08530  -18.80991 1.000 31.57967 ? 156 THR A O   1 
ATOM   1207 C  CB  . THR A 1 156 ? -40.81600 -0.12562 -18.18215 1.000 45.69779 ? 156 THR A CB  1 
ATOM   1208 O  OG1 . THR A 1 156 ? -41.22253 1.21724  -18.46370 1.000 49.52038 ? 156 THR A OG1 1 
ATOM   1209 C  CG2 . THR A 1 156 ? -41.95440 -0.84335 -17.46524 1.000 42.64132 ? 156 THR A CG2 1 
ATOM   1210 N  N   . SER A 1 157 ? -38.26842 1.96072  -17.72685 1.000 31.97644 ? 157 SER A N   1 
ATOM   1211 C  CA  . SER A 1 157 ? -37.18506 2.72133  -18.34176 1.000 23.94978 ? 157 SER A CA  1 
ATOM   1212 C  C   . SER A 1 157 ? -35.98703 2.93532  -17.41691 1.000 17.78837 ? 157 SER A C   1 
ATOM   1213 O  O   . SER A 1 157 ? -35.02146 3.59843  -17.82483 1.000 13.30777 ? 157 SER A O   1 
ATOM   1214 C  CB  . SER A 1 157 ? -37.69889 4.07111  -18.84662 1.000 28.63608 ? 157 SER A CB  1 
ATOM   1215 O  OG  . SER A 1 157 ? -38.72095 4.58185  -18.00869 1.000 48.95419 ? 157 SER A OG  1 
ATOM   1216 N  N   . ALA A 1 158 ? -36.00683 2.37575  -16.19839 1.000 16.49901 ? 158 ALA A N   1 
ATOM   1217 C  CA  . ALA A 1 158 ? -34.94832 2.67491  -15.23001 1.000 14.39097 ? 158 ALA A CA  1 
ATOM   1218 C  C   . ALA A 1 158 ? -33.59451 2.16708  -15.71182 1.000 13.68496 ? 158 ALA A C   1 
ATOM   1219 O  O   . ALA A 1 158 ? -32.58531 2.87551  -15.63287 1.000 12.91095 ? 158 ALA A O   1 
ATOM   1220 C  CB  . ALA A 1 158 ? -35.28971 2.08244  -13.85285 1.000 13.78051 ? 158 ALA A CB  1 
ATOM   1221 N  N   . TYR A 1 159 ? -33.54618 0.93588  -16.21336 1.000 14.23450 ? 159 TYR A N   1 
ATOM   1222 C  CA  . TYR A 1 159 ? -32.26164 0.36225  -16.59142 1.000 13.60694 ? 159 TYR A CA  1 
ATOM   1223 C  C   . TYR A 1 159 ? -31.60213 1.16670  -17.70958 1.000 16.29032 ? 159 TYR A C   1 
ATOM   1224 O  O   . TYR A 1 159 ? -30.40056 1.46829  -17.65084 1.000 16.14540 ? 159 TYR A O   1 
ATOM   1225 C  CB  . TYR A 1 159 ? -32.44657 -1.09573 -17.00722 1.000 13.48478 ? 159 TYR A CB  1 
ATOM   1226 C  CG  . TYR A 1 159 ? -31.14788 -1.77893 -17.34658 1.000 15.35709 ? 159 TYR A CG  1 
ATOM   1227 C  CD1 . TYR A 1 159 ? -30.18069 -1.99493 -16.37339 1.000 12.89398 ? 159 TYR A CD1 1 
ATOM   1228 C  CD2 . TYR A 1 159 ? -30.88076 -2.20314 -18.64649 1.000 13.73320 ? 159 TYR A CD2 1 
ATOM   1229 C  CE1 . TYR A 1 159 ? -28.99404 -2.61797 -16.67554 1.000 14.76262 ? 159 TYR A CE1 1 
ATOM   1230 C  CE2 . TYR A 1 159 ? -29.68208 -2.82166 -18.95987 1.000 12.54651 ? 159 TYR A CE2 1 
ATOM   1231 C  CZ  . TYR A 1 159 ? -28.74593 -3.02259 -17.97210 1.000 16.40844 ? 159 TYR A CZ  1 
ATOM   1232 O  OH  . TYR A 1 159 ? -27.56315 -3.64469 -18.26756 1.000 15.72379 ? 159 TYR A OH  1 
ATOM   1233 N  N   . MET A 1 160 ? -32.36766 1.49597  -18.75507 1.000 11.72015 ? 160 MET A N   1 
ATOM   1234 C  CA  . MET A 1 160 ? -31.84922 2.36796  -19.80459 1.000 13.64675 ? 160 MET A CA  1 
ATOM   1235 C  C   . MET A 1 160 ? -31.26846 3.65511  -19.26341 1.000 16.53708 ? 160 MET A C   1 
ATOM   1236 O  O   . MET A 1 160 ? -30.20982 4.10699  -19.71525 1.000 18.45318 ? 160 MET A O   1 
ATOM   1237 C  CB  . MET A 1 160 ? -32.92456 2.67416  -20.85155 1.000 10.19223 ? 160 MET A CB  1 
ATOM   1238 C  CG  . MET A 1 160 ? -32.27709 3.43486  -21.98669 1.000 15.18947 ? 160 MET A CG  1 
ATOM   1239 S  SD  . MET A 1 160 ? -31.32594 2.48888  -23.16152 1.000 24.58929 ? 160 MET A SD  1 
ATOM   1240 C  CE  . MET A 1 160 ? -32.37176 1.03429  -23.28476 1.000 29.52606 ? 160 MET A CE  1 
ATOM   1241 N  N   . ALA A 1 161 ? -31.94561 4.26813  -18.30450 1.000 12.60687 ? 161 ALA A N   1 
ATOM   1242 C  CA  . ALA A 1 161 ? -31.43483 5.50847  -17.72722 1.000 9.82985  ? 161 ALA A CA  1 
ATOM   1243 C  C   . ALA A 1 161 ? -30.11486 5.27646  -16.99826 1.000 13.00405 ? 161 ALA A C   1 
ATOM   1244 O  O   . ALA A 1 161 ? -29.18205 6.07783  -17.12150 1.000 14.09927 ? 161 ALA A O   1 
ATOM   1245 C  CB  . ALA A 1 161 ? -32.48293 6.11288  -16.78971 1.000 13.82695 ? 161 ALA A CB  1 
ATOM   1246 N  N   . MET A 1 162 ? -30.01818 4.18925  -16.22688 1.000 13.04082 ? 162 MET A N   1 
ATOM   1247 C  CA  . MET A 1 162 ? -28.74901 3.85129  -15.58744 1.000 15.22306 ? 162 MET A CA  1 
ATOM   1248 C  C   . MET A 1 162 ? -27.62417 3.74013  -16.60681 1.000 21.25766 ? 162 MET A C   1 
ATOM   1249 O  O   . MET A 1 162 ? -26.50819 4.21384  -16.36232 1.000 15.69494 ? 162 MET A O   1 
ATOM   1250 C  CB  . MET A 1 162 ? -28.88774 2.55083  -14.78784 1.000 17.13570 ? 162 MET A CB  1 
ATOM   1251 C  CG  . MET A 1 162 ? -29.84342 2.70287  -13.59971 1.000 17.42290 ? 162 MET A CG  1 
ATOM   1252 S  SD  . MET A 1 162 ? -30.32630 1.13687  -12.85025 1.000 21.79758 ? 162 MET A SD  1 
ATOM   1253 C  CE  . MET A 1 162 ? -29.22124 1.06133  -11.46601 1.000 32.80858 ? 162 MET A CE  1 
ATOM   1254 N  N   . ILE A 1 163 ? -27.89730 3.12093  -17.75687 1.000 12.39770 ? 163 ILE A N   1 
ATOM   1255 C  CA  . ILE A 1 163 ? -26.85104 2.88106  -18.75102 1.000 19.03745 ? 163 ILE A CA  1 
ATOM   1256 C  C   . ILE A 1 163 ? -26.58449 4.12026  -19.58816 1.000 17.19152 ? 163 ILE A C   1 
ATOM   1257 O  O   . ILE A 1 163 ? -25.42576 4.44547  -19.89216 1.000 17.57683 ? 163 ILE A O   1 
ATOM   1258 C  CB  . ILE A 1 163 ? -27.22072 1.69499  -19.66273 1.000 17.19699 ? 163 ILE A CB  1 
ATOM   1259 C  CG1 . ILE A 1 163 ? -27.29971 0.39528  -18.85370 1.000 20.00713 ? 163 ILE A CG1 1 
ATOM   1260 C  CG2 . ILE A 1 163 ? -26.23190 1.63027  -20.85550 1.000 18.33714 ? 163 ILE A CG2 1 
ATOM   1261 C  CD1 . ILE A 1 163 ? -25.97605 -0.30399 -18.67975 1.000 29.17823 ? 163 ILE A CD1 1 
ATOM   1262 N  N   . ASN A 1 164 ? -27.63916 4.80890  -20.00651 1.000 15.59888 ? 164 ASN A N   1 
ATOM   1263 C  CA  . ASN A 1 164 ? -27.52323 5.80205  -21.06618 1.000 18.04542 ? 164 ASN A CA  1 
ATOM   1264 C  C   . ASN A 1 164 ? -27.96133 7.19261  -20.64378 1.000 15.82879 ? 164 ASN A C   1 
ATOM   1265 O  O   . ASN A 1 164 ? -27.94285 8.10842  -21.47174 1.000 18.97674 ? 164 ASN A O   1 
ATOM   1266 C  CB  . ASN A 1 164 ? -28.33676 5.35101  -22.28829 1.000 18.33233 ? 164 ASN A CB  1 
ATOM   1267 C  CG  . ASN A 1 164 ? -27.88700 6.02175  -23.57289 1.000 26.83685 ? 164 ASN A CG  1 
ATOM   1268 O  OD1 . ASN A 1 164 ? -26.70808 6.33227  -23.74652 1.000 24.80447 ? 164 ASN A OD1 1 
ATOM   1269 N  ND2 . ASN A 1 164 ? -28.83606 6.26478  -24.47507 1.000 26.65074 ? 164 ASN A ND2 1 
ATOM   1270 N  N   . GLY A 1 165 ? -28.34479 7.38513  -19.38639 1.000 13.88296 ? 165 GLY A N   1 
ATOM   1271 C  CA  . GLY A 1 165 ? -28.79154 8.68122  -18.92740 1.000 15.33432 ? 165 GLY A CA  1 
ATOM   1272 C  C   . GLY A 1 165 ? -30.26488 8.91395  -19.19964 1.000 17.97219 ? 165 GLY A C   1 
ATOM   1273 O  O   . GLY A 1 165 ? -30.92982 8.17533  -19.92298 1.000 14.97415 ? 165 GLY A O   1 
ATOM   1274 N  N   . GLY A 1 166 ? -30.78733 9.96607  -18.57185 1.000 15.36385 ? 166 GLY A N   1 
ATOM   1275 C  CA  . GLY A 1 166 ? -32.17362 10.31309 -18.70716 1.000 14.96817 ? 166 GLY A CA  1 
ATOM   1276 C  C   . GLY A 1 166 ? -32.38438 11.26315 -19.86122 1.000 14.04196 ? 166 GLY A C   1 
ATOM   1277 O  O   . GLY A 1 166 ? -31.48814 11.49976 -20.69243 1.000 12.96702 ? 166 GLY A O   1 
ATOM   1278 N  N   . PRO A 1 167 ? -33.59095 11.81611 -19.93545 1.000 15.97696 ? 167 PRO A N   1 
ATOM   1279 C  CA  . PRO A 1 167 ? -33.90497 12.79620 -20.97648 1.000 16.66000 ? 167 PRO A CA  1 
ATOM   1280 C  C   . PRO A 1 167 ? -33.10074 14.07879 -20.80354 1.000 16.95157 ? 167 PRO A C   1 
ATOM   1281 O  O   . PRO A 1 167 ? -32.39847 14.29741 -19.81399 1.000 16.25126 ? 167 PRO A O   1 
ATOM   1282 C  CB  . PRO A 1 167 ? -35.41017 13.05355 -20.78560 1.000 18.50988 ? 167 PRO A CB  1 
ATOM   1283 C  CG  . PRO A 1 167 ? -35.91243 11.91583 -19.94160 1.000 19.08065 ? 167 PRO A CG  1 
ATOM   1284 C  CD  . PRO A 1 167 ? -34.76212 11.48700 -19.09808 1.000 15.41599 ? 167 PRO A CD  1 
ATOM   1285 N  N   . ASP A 1 168 ? -33.23585 14.94420 -21.79771 1.000 14.71301 ? 168 ASP A N   1 
ATOM   1286 C  CA  . ASP A 1 168 ? -32.63270 16.27543 -21.84878 1.000 16.68047 ? 168 ASP A CA  1 
ATOM   1287 C  C   . ASP A 1 168 ? -32.61633 16.93388 -20.47865 1.000 15.64996 ? 168 ASP A C   1 
ATOM   1288 O  O   . ASP A 1 168 ? -33.67783 17.25775 -19.93702 1.000 13.47575 ? 168 ASP A O   1 
ATOM   1289 C  CB  . ASP A 1 168 ? -33.38438 17.14371 -22.86391 1.000 19.85748 ? 168 ASP A CB  1 
ATOM   1290 C  CG  . ASP A 1 168 ? -33.12835 18.64312 -22.67952 1.000 22.41071 ? 168 ASP A CG  1 
ATOM   1291 O  OD1 . ASP A 1 168 ? -31.99183 19.04624 -22.36084 1.000 22.85085 ? 168 ASP A OD1 1 
ATOM   1292 O  OD2 . ASP A 1 168 ? -34.07522 19.43414 -22.88994 1.000 37.14681 ? 168 ASP A OD2 1 
ATOM   1293 N  N   . PRO A 1 169 ? -31.43393 17.16592 -19.89926 1.000 11.30309 ? 169 PRO A N   1 
ATOM   1294 C  CA  . PRO A 1 169 ? -31.37975 17.71725 -18.52944 1.000 13.06606 ? 169 PRO A CA  1 
ATOM   1295 C  C   . PRO A 1 169 ? -32.03310 19.08028 -18.37636 1.000 13.20848 ? 169 PRO A C   1 
ATOM   1296 O  O   . PRO A 1 169 ? -32.53086 19.38880 -17.28660 1.000 11.45111 ? 169 PRO A O   1 
ATOM   1297 C  CB  . PRO A 1 169 ? -29.87179 17.79556 -18.24086 1.000 15.11652 ? 169 PRO A CB  1 
ATOM   1298 C  CG  . PRO A 1 169 ? -29.26173 16.73538 -19.13260 1.000 12.41167 ? 169 PRO A CG  1 
ATOM   1299 C  CD  . PRO A 1 169 ? -30.11030 16.74322 -20.38979 1.000 12.76044 ? 169 PRO A CD  1 
ATOM   1300 N  N   . VAL A 1 170 ? -32.02228 19.92403 -19.41111 1.000 13.09757 ? 170 VAL A N   1 
ATOM   1301 C  CA  . VAL A 1 170 ? -32.71259 21.20840 -19.29207 1.000 11.30189 ? 170 VAL A CA  1 
ATOM   1302 C  C   . VAL A 1 170 ? -34.20946 20.98920 -19.08833 1.000 15.00869 ? 170 VAL A C   1 
ATOM   1303 O  O   . VAL A 1 170 ? -34.83873 21.63606 -18.23920 1.000 15.79405 ? 170 VAL A O   1 
ATOM   1304 C  CB  . VAL A 1 170 ? -32.42405 22.09986 -20.51444 1.000 25.25636 ? 170 VAL A CB  1 
ATOM   1305 C  CG1 . VAL A 1 170 ? -33.28643 23.37885 -20.45603 1.000 19.74444 ? 170 VAL A CG1 1 
ATOM   1306 C  CG2 . VAL A 1 170 ? -30.94461 22.43591 -20.59000 1.000 20.04531 ? 170 VAL A CG2 1 
ATOM   1307 N  N   . GLN A 1 171 ? -34.80514 20.06686 -19.84863 1.000 16.40652 ? 171 GLN A N   1 
ATOM   1308 C  CA  . GLN A 1 171 ? -36.21200 19.74402 -19.62170 1.000 18.99286 ? 171 GLN A CA  1 
ATOM   1309 C  C   . GLN A 1 171 ? -36.44083 19.14839 -18.23368 1.000 16.55975 ? 171 GLN A C   1 
ATOM   1310 O  O   . GLN A 1 171 ? -37.38068 19.53503 -17.52227 1.000 15.79773 ? 171 GLN A O   1 
ATOM   1311 C  CB  . GLN A 1 171 ? -36.72300 18.79042 -20.70351 1.000 22.42165 ? 171 GLN A CB  1 
ATOM   1312 C  CG  . GLN A 1 171 ? -38.23451 18.79825 -20.83812 1.000 25.95660 ? 171 GLN A CG  1 
ATOM   1313 C  CD  . GLN A 1 171 ? -38.82312 20.19084 -20.75871 1.000 41.12584 ? 171 GLN A CD  1 
ATOM   1314 O  OE1 . GLN A 1 171 ? -39.95615 20.37329 -20.30756 1.000 49.78106 ? 171 GLN A OE1 1 
ATOM   1315 N  NE2 . GLN A 1 171 ? -38.07733 21.18090 -21.24289 1.000 57.15597 ? 171 GLN A NE2 1 
ATOM   1316 N  N   . GLN A 1 172 ? -35.62094 18.17326 -17.84261 1.000 12.77961 ? 172 GLN A N   1 
ATOM   1317 C  CA  . GLN A 1 172 ? -35.77911 17.60119 -16.50501 1.000 14.44047 ? 172 GLN A CA  1 
ATOM   1318 C  C   . GLN A 1 172 ? -35.57181 18.65903 -15.43211 1.000 12.70154 ? 172 GLN A C   1 
ATOM   1319 O  O   . GLN A 1 172 ? -36.22015 18.61131 -14.37488 1.000 13.28575 ? 172 GLN A O   1 
ATOM   1320 C  CB  . GLN A 1 172 ? -34.81553 16.42256 -16.31415 1.000 13.30177 ? 172 GLN A CB  1 
ATOM   1321 C  CG  . GLN A 1 172 ? -35.00828 15.31982 -17.36752 1.000 14.79690 ? 172 GLN A CG  1 
ATOM   1322 C  CD  . GLN A 1 172 ? -36.48969 15.00702 -17.59244 1.000 17.21150 ? 172 GLN A CD  1 
ATOM   1323 O  OE1 . GLN A 1 172 ? -37.09462 15.46686 -18.56014 1.000 18.20298 ? 172 GLN A OE1 1 
ATOM   1324 N  NE2 . GLN A 1 172 ? -37.07598 14.23380 -16.68867 1.000 15.02642 ? 172 GLN A NE2 1 
ATOM   1325 N  N   . GLY A 1 173 ? -34.69468 19.63735 -15.69327 1.000 12.77075 ? 173 GLY A N   1 
ATOM   1326 C  CA  . GLY A 1 173 ? -34.51130 20.73653 -14.75789 1.000 11.71227 ? 173 GLY A CA  1 
ATOM   1327 C  C   . GLY A 1 173 ? -35.74101 21.61914 -14.62356 1.000 14.86282 ? 173 GLY A C   1 
ATOM   1328 O  O   . GLY A 1 173 ? -36.01734 22.15385 -13.53591 1.000 11.51905 ? 173 GLY A O   1 
ATOM   1329 N  N   . ASN A 1 174 ? -36.48377 21.80347 -15.71872 1.000 11.77975 ? 174 ASN A N   1 
ATOM   1330 C  CA  . ASN A 1 174 ? -37.77191 22.50144 -15.63727 1.000 15.03171 ? 174 ASN A CA  1 
ATOM   1331 C  C   . ASN A 1 174 ? -38.77070 21.72015 -14.79811 1.000 15.76950 ? 174 ASN A C   1 
ATOM   1332 O  O   . ASN A 1 174 ? -39.49353 22.29637 -13.96965 1.000 15.07422 ? 174 ASN A O   1 
ATOM   1333 C  CB  . ASN A 1 174 ? -38.34659 22.74218 -17.03619 1.000 14.20993 ? 174 ASN A CB  1 
ATOM   1334 C  CG  . ASN A 1 174 ? -37.60610 23.83378 -17.77759 1.000 15.57497 ? 174 ASN A CG  1 
ATOM   1335 O  OD1 . ASN A 1 174 ? -36.99984 24.70402 -17.16141 1.000 13.79858 ? 174 ASN A OD1 1 
ATOM   1336 N  ND2 . ASN A 1 174 ? -37.66560 23.80506 -19.09481 1.000 14.81394 ? 174 ASN A ND2 1 
ATOM   1337 N  N   . LEU A 1 175 ? -38.81973 20.40053 -14.98579 1.000 14.34672 ? 175 LEU A N   1 
ATOM   1338 C  CA  . LEU A 1 175 ? -39.73911 19.59369 -14.19479 1.000 14.39949 ? 175 LEU A CA  1 
ATOM   1339 C  C   . LEU A 1 175 ? -39.36175 19.63160 -12.71626 1.000 17.31436 ? 175 LEU A C   1 
ATOM   1340 O  O   . LEU A 1 175 ? -40.23963 19.70222 -11.84439 1.000 12.85372 ? 175 LEU A O   1 
ATOM   1341 C  CB  . LEU A 1 175 ? -39.75856 18.16304 -14.72817 1.000 13.44457 ? 175 LEU A CB  1 
ATOM   1342 C  CG  . LEU A 1 175 ? -40.28820 18.00488 -16.15940 1.000 16.67085 ? 175 LEU A CG  1 
ATOM   1343 C  CD1 . LEU A 1 175 ? -40.17760 16.56620 -16.60516 1.000 18.69427 ? 175 LEU A CD1 1 
ATOM   1344 C  CD2 . LEU A 1 175 ? -41.73321 18.49545 -16.25489 1.000 15.64500 ? 175 LEU A CD2 1 
ATOM   1345 N  N   . ALA A 1 176 ? -38.06287 19.59088 -12.40813 1.000 9.64003  ? 176 ALA A N   1 
ATOM   1346 C  CA  . ALA A 1 176 ? -37.66477 19.67444 -11.00265 1.000 11.71516 ? 176 ALA A CA  1 
ATOM   1347 C  C   . ALA A 1 176 ? -38.04848 21.02493 -10.42287 1.000 9.33108  ? 176 ALA A C   1 
ATOM   1348 O  O   . ALA A 1 176 ? -38.48700 21.11793 -9.26662  1.000 10.51000 ? 176 ALA A O   1 
ATOM   1349 C  CB  . ALA A 1 176 ? -36.15866 19.44165 -10.84487 1.000 9.66493  ? 176 ALA A CB  1 
ATOM   1350 N  N   . TYR A 1 177 ? -37.87077 22.08812 -11.21491 1.000 12.79640 ? 177 TYR A N   1 
ATOM   1351 C  CA  . TYR A 1 177 ? -38.28524 23.41883 -10.78664 1.000 18.39880 ? 177 TYR A CA  1 
ATOM   1352 C  C   . TYR A 1 177 ? -39.78015 23.46558 -10.51277 1.000 11.99069 ? 177 TYR A C   1 
ATOM   1353 O  O   . TYR A 1 177 ? -40.21705 24.03784 -9.50798  1.000 14.78345 ? 177 TYR A O   1 
ATOM   1354 C  CB  . TYR A 1 177 ? -37.93580 24.44942 -11.85650 1.000 13.65418 ? 177 TYR A CB  1 
ATOM   1355 C  CG  . TYR A 1 177 ? -38.43637 25.83709 -11.52480 1.000 16.21169 ? 177 TYR A CG  1 
ATOM   1356 C  CD1 . TYR A 1 177 ? -38.08101 26.47652 -10.34602 1.000 12.55857 ? 177 TYR A CD1 1 
ATOM   1357 C  CD2 . TYR A 1 177 ? -39.40634 26.43457 -12.32659 1.000 23.23527 ? 177 TYR A CD2 1 
ATOM   1358 C  CE1 . TYR A 1 177 ? -38.57609 27.73686 -10.03799 1.000 19.17530 ? 177 TYR A CE1 1 
ATOM   1359 C  CE2 . TYR A 1 177 ? -39.92321 27.67231 -12.01550 1.000 17.42580 ? 177 TYR A CE2 1 
ATOM   1360 C  CZ  . TYR A 1 177 ? -39.49491 28.32436 -10.88355 1.000 24.62449 ? 177 TYR A CZ  1 
ATOM   1361 O  OH  . TYR A 1 177 ? -40.01646 29.56166 -10.60504 1.000 20.74107 ? 177 TYR A OH  1 
ATOM   1362 N  N   A GLN A 1 178 ? -40.58003 22.90240 -11.43002 0.597 12.64009 ? 178 GLN A N   1 
ATOM   1363 N  N   B GLN A 1 178 ? -40.59100 22.87738 -11.38928 0.403 12.68797 ? 178 GLN A N   1 
ATOM   1364 C  CA  A GLN A 1 178 ? -42.02502 22.80235 -11.22349 0.597 15.18566 ? 178 GLN A CA  1 
ATOM   1365 C  CA  B GLN A 1 178 ? -42.02893 22.89682 -11.13627 0.403 15.08804 ? 178 GLN A CA  1 
ATOM   1366 C  C   A GLN A 1 178 ? -42.33974 22.03566 -9.94350  0.597 15.54700 ? 178 GLN A C   1 
ATOM   1367 C  C   B GLN A 1 178 ? -42.40942 21.98834 -9.96688  0.403 15.52381 ? 178 GLN A C   1 
ATOM   1368 O  O   A GLN A 1 178 ? -43.19655 22.44846 -9.15152  0.597 15.25449 ? 178 GLN A O   1 
ATOM   1369 O  O   B GLN A 1 178 ? -43.40275 22.25215 -9.27877  0.403 15.28736 ? 178 GLN A O   1 
ATOM   1370 C  CB  A GLN A 1 178 ? -42.69292 22.12028 -12.43369 0.597 16.09123 ? 178 GLN A CB  1 
ATOM   1371 C  CB  B GLN A 1 178 ? -42.79294 22.50723 -12.40120 0.403 17.08397 ? 178 GLN A CB  1 
ATOM   1372 C  CG  A GLN A 1 178 ? -42.57140 22.88795 -13.77639 0.597 15.90650 ? 178 GLN A CG  1 
ATOM   1373 C  CG  B GLN A 1 178 ? -42.73172 23.53785 -13.53990 0.403 15.58493 ? 178 GLN A CG  1 
ATOM   1374 C  CD  A GLN A 1 178 ? -42.98630 22.07968 -15.03772 0.597 18.29475 ? 178 GLN A CD  1 
ATOM   1375 C  CD  B GLN A 1 178 ? -42.98680 24.97689 -13.09284 0.403 14.46325 ? 178 GLN A CD  1 
ATOM   1376 O  OE1 A GLN A 1 178 ? -44.00964 21.38566 -15.06233 0.597 10.28163 ? 178 GLN A OE1 1 
ATOM   1377 O  OE1 B GLN A 1 178 ? -43.73636 25.22685 -12.15254 0.403 12.95634 ? 178 GLN A OE1 1 
ATOM   1378 N  NE2 A GLN A 1 178 ? -42.17085 22.17757 -16.08622 0.597 11.61576 ? 178 GLN A NE2 1 
ATOM   1379 N  NE2 B GLN A 1 178 ? -42.38618 25.92872 -13.79958 0.403 14.47476 ? 178 GLN A NE2 1 
ATOM   1380 N  N   . ALA A 1 179 ? -41.63569 20.92691 -9.71294  1.000 12.93883 ? 179 ALA A N   1 
ATOM   1381 C  CA  . ALA A 1 179 ? -41.88933 20.10013 -8.53735  1.000 12.58064 ? 179 ALA A CA  1 
ATOM   1382 C  C   . ALA A 1 179 ? -41.69568 20.87634 -7.24275  1.000 13.76979 ? 179 ALA A C   1 
ATOM   1383 O  O   . ALA A 1 179 ? -42.26062 20.50156 -6.20838  1.000 12.97770 ? 179 ALA A O   1 
ATOM   1384 C  CB  . ALA A 1 179 ? -40.96663 18.87506 -8.55590  1.000 11.78305 ? 179 ALA A CB  1 
ATOM   1385 N  N   . MET A 1 180 ? -40.91241 21.95539 -7.28975  1.000 14.30003 ? 180 MET A N   1 
ATOM   1386 C  CA  . MET A 1 180 ? -40.63151 22.76771 -6.11108  1.000 12.85597 ? 180 MET A CA  1 
ATOM   1387 C  C   . MET A 1 180 ? -41.84866 23.58193 -5.68777  1.000 15.69805 ? 180 MET A C   1 
ATOM   1388 O  O   . MET A 1 180 ? -41.95705 23.98041 -4.51701  1.000 12.51237 ? 180 MET A O   1 
ATOM   1389 C  CB  . MET A 1 180 ? -39.47367 23.69824 -6.44160  1.000 14.66245 ? 180 MET A CB  1 
ATOM   1390 C  CG  . MET A 1 180 ? -38.11466 23.09000 -6.23128  1.000 10.69986 ? 180 MET A CG  1 
ATOM   1391 S  SD  . MET A 1 180 ? -36.85406 24.29263 -6.65766  1.000 14.60207 ? 180 MET A SD  1 
ATOM   1392 C  CE  . MET A 1 180 ? -35.38328 23.23463 -6.65838  1.000 12.29562 ? 180 MET A CE  1 
ATOM   1393 N  N   . GLY A 1 181 ? -42.73992 23.87768 -6.63070  1.000 15.52752 ? 181 GLY A N   1 
ATOM   1394 C  CA  . GLY A 1 181 ? -43.89212 24.71487 -6.32090  1.000 16.74054 ? 181 GLY A CA  1 
ATOM   1395 C  C   . GLY A 1 181 ? -43.46361 26.04953 -5.73468  1.000 13.04134 ? 181 GLY A C   1 
ATOM   1396 O  O   . GLY A 1 181 ? -42.42828 26.62208 -6.10397  1.000 13.92892 ? 181 GLY A O   1 
ATOM   1397 N  N   . SER A 1 182 ? -44.25110 26.54264 -4.77763  1.000 11.56043 ? 182 SER A N   1 
ATOM   1398 C  CA  . SER A 1 182 ? -43.96851 27.83387 -4.16390  1.000 15.71749 ? 182 SER A CA  1 
ATOM   1399 C  C   . SER A 1 182 ? -42.77472 27.78747 -3.21382  1.000 19.09840 ? 182 SER A C   1 
ATOM   1400 O  O   . SER A 1 182 ? -42.41760 28.82267 -2.64301  1.000 14.83258 ? 182 SER A O   1 
ATOM   1401 C  CB  . SER A 1 182 ? -45.20508 28.34454 -3.40072  1.000 16.09510 ? 182 SER A CB  1 
ATOM   1402 O  OG  . SER A 1 182 ? -45.58039 27.42359 -2.37973  1.000 20.26097 ? 182 SER A OG  1 
ATOM   1403 N  N   . HIS A 1 183 ? -42.15104 26.63032 -3.02724  1.000 19.51354 ? 183 HIS A N   1 
ATOM   1404 C  CA  . HIS A 1 183 ? -40.96846 26.51506 -2.18231  1.000 11.10724 ? 183 HIS A CA  1 
ATOM   1405 C  C   . HIS A 1 183 ? -39.67600 26.69612 -2.96292  1.000 12.76983 ? 183 HIS A C   1 
ATOM   1406 O  O   . HIS A 1 183 ? -38.59262 26.57567 -2.38324  1.000 12.92536 ? 183 HIS A O   1 
ATOM   1407 C  CB  . HIS A 1 183 ? -40.94746 25.15096 -1.48564  1.000 13.06910 ? 183 HIS A CB  1 
ATOM   1408 C  CG  . HIS A 1 183 ? -42.21835 24.81395 -0.76900  1.000 16.36083 ? 183 HIS A CG  1 
ATOM   1409 N  ND1 . HIS A 1 183 ? -43.21802 24.05098 -1.33661  1.000 22.23807 ? 183 HIS A ND1 1 
ATOM   1410 C  CD2 . HIS A 1 183 ? -42.66129 25.15328 0.46741   1.000 14.99976 ? 183 HIS A CD2 1 
ATOM   1411 C  CE1 . HIS A 1 183 ? -44.21199 23.91979 -0.47691  1.000 16.99116 ? 183 HIS A CE1 1 
ATOM   1412 N  NE2 . HIS A 1 183 ? -43.90014 24.57856 0.62521   1.000 19.25711 ? 183 HIS A NE2 1 
ATOM   1413 N  N   . ALA A 1 184 ? -39.77222 26.97620 -4.25690  1.000 16.95541 ? 184 ALA A N   1 
ATOM   1414 C  CA  . ALA A 1 184 ? -38.59627 27.02811 -5.11460  1.000 17.48541 ? 184 ALA A CA  1 
ATOM   1415 C  C   . ALA A 1 184 ? -37.51363 27.91751 -4.51894  1.000 18.80404 ? 184 ALA A C   1 
ATOM   1416 O  O   . ALA A 1 184 ? -37.78561 28.99261 -3.98426  1.000 14.69657 ? 184 ALA A O   1 
ATOM   1417 C  CB  . ALA A 1 184 ? -38.99125 27.52789 -6.50748  1.000 16.74090 ? 184 ALA A CB  1 
ATOM   1418 N  N   . ARG A 1 185 ? -36.27572 27.44239 -4.60376  1.000 13.11002 ? 185 ARG A N   1 
ATOM   1419 C  CA  . ARG A 1 185 ? -35.08116 28.17216 -4.20291  1.000 14.06900 ? 185 ARG A CA  1 
ATOM   1420 C  C   . ARG A 1 185 ? -33.90731 27.40113 -4.77019  1.000 13.48465 ? 185 ARG A C   1 
ATOM   1421 O  O   . ARG A 1 185 ? -34.03081 26.21489 -5.10022  1.000 12.04847 ? 185 ARG A O   1 
ATOM   1422 C  CB  . ARG A 1 185 ? -34.95066 28.31601 -2.67617  1.000 16.05396 ? 185 ARG A CB  1 
ATOM   1423 C  CG  . ARG A 1 185 ? -34.92175 26.97892 -1.91712  1.000 13.39094 ? 185 ARG A CG  1 
ATOM   1424 C  CD  . ARG A 1 185 ? -34.49384 27.15870 -0.46543  1.000 15.03182 ? 185 ARG A CD  1 
ATOM   1425 N  NE  . ARG A 1 185 ? -33.04062 27.16052 -0.30358  1.000 13.68076 ? 185 ARG A NE  1 
ATOM   1426 C  CZ  . ARG A 1 185 ? -32.29640 26.06483 -0.22913  1.000 18.90215 ? 185 ARG A CZ  1 
ATOM   1427 N  NH1 . ARG A 1 185 ? -32.83368 24.85624 -0.32059  1.000 12.14227 ? 185 ARG A NH1 1 
ATOM   1428 N  NH2 . ARG A 1 185 ? -30.98311 26.18410 -0.05366  1.000 12.83424 ? 185 ARG A NH2 1 
ATOM   1429 N  N   . VAL A 1 186 ? -32.77774 28.09645 -4.90544  1.000 14.50565 ? 186 VAL A N   1 
ATOM   1430 C  CA  . VAL A 1 186 ? -31.55278 27.43909 -5.33876  1.000 14.56941 ? 186 VAL A CA  1 
ATOM   1431 C  C   . VAL A 1 186 ? -31.15639 26.39117 -4.31515  1.000 13.56441 ? 186 VAL A C   1 
ATOM   1432 O  O   . VAL A 1 186 ? -31.09012 26.66462 -3.10886  1.000 13.97460 ? 186 VAL A O   1 
ATOM   1433 C  CB  . VAL A 1 186 ? -30.43002 28.46805 -5.53100  1.000 11.76356 ? 186 VAL A CB  1 
ATOM   1434 C  CG1 . VAL A 1 186 ? -29.08990 27.75880 -5.70442  1.000 14.41373 ? 186 VAL A CG1 1 
ATOM   1435 C  CG2 . VAL A 1 186 ? -30.73254 29.35188 -6.71626  1.000 12.13417 ? 186 VAL A CG2 1 
ATOM   1436 N  N   . VAL A 1 187 ? -30.88930 25.18616 -4.79225  1.000 12.01394 ? 187 VAL A N   1 
ATOM   1437 C  CA  . VAL A 1 187 ? -30.41004 24.08649 -3.95713  1.000 7.83346  ? 187 VAL A CA  1 
ATOM   1438 C  C   . VAL A 1 187 ? -28.99829 23.73591 -4.41412  1.000 10.89360 ? 187 VAL A C   1 
ATOM   1439 O  O   . VAL A 1 187 ? -28.84567 23.09338 -5.46086  1.000 12.42809 ? 187 VAL A O   1 
ATOM   1440 C  CB  . VAL A 1 187 ? -31.32958 22.85786 -4.06851  1.000 9.78370  ? 187 VAL A CB  1 
ATOM   1441 C  CG1 . VAL A 1 187 ? -30.78294 21.72710 -3.21312  1.000 8.45317  ? 187 VAL A CG1 1 
ATOM   1442 C  CG2 . VAL A 1 187 ? -32.77827 23.21056 -3.65980  1.000 12.56232 ? 187 VAL A CG2 1 
ATOM   1443 N  N   . PRO A 1 188 ? -27.94527 24.10219 -3.68916  1.000 9.70019  ? 188 PRO A N   1 
ATOM   1444 C  CA  . PRO A 1 188 ? -26.60184 23.69049 -4.12875  1.000 9.64842  ? 188 PRO A CA  1 
ATOM   1445 C  C   . PRO A 1 188 ? -26.49009 22.17395 -4.11869  1.000 10.34002 ? 188 PRO A C   1 
ATOM   1446 O  O   . PRO A 1 188 ? -27.10472 21.48972 -3.29505  1.000 9.86971  ? 188 PRO A O   1 
ATOM   1447 C  CB  . PRO A 1 188 ? -25.66711 24.34161 -3.10515  1.000 11.80650 ? 188 PRO A CB  1 
ATOM   1448 C  CG  . PRO A 1 188 ? -26.48646 25.56820 -2.61639  1.000 12.40827 ? 188 PRO A CG  1 
ATOM   1449 C  CD  . PRO A 1 188 ? -27.90171 25.04920 -2.56277  1.000 13.30819 ? 188 PRO A CD  1 
ATOM   1450 N  N   . VAL A 1 189 ? -25.70252 21.65614 -5.06058  1.000 10.74782 ? 189 VAL A N   1 
ATOM   1451 C  CA  . VAL A 1 189 ? -25.56367 20.22439 -5.31010  1.000 10.54357 ? 189 VAL A CA  1 
ATOM   1452 C  C   . VAL A 1 189 ? -24.09049 19.90995 -5.45137  1.000 11.21912 ? 189 VAL A C   1 
ATOM   1453 O  O   . VAL A 1 189 ? -23.39404 20.56764 -6.23032  1.000 11.48143 ? 189 VAL A O   1 
ATOM   1454 C  CB  . VAL A 1 189 ? -26.28253 19.79273 -6.60621  1.000 12.31916 ? 189 VAL A CB  1 
ATOM   1455 C  CG1 . VAL A 1 189 ? -26.08174 18.29064 -6.84755  1.000 11.96472 ? 189 VAL A CG1 1 
ATOM   1456 C  CG2 . VAL A 1 189 ? -27.75157 20.16398 -6.56978  1.000 18.28659 ? 189 VAL A CG2 1 
ATOM   1457 N  N   . ILE A 1 190 ? -23.62542 18.87646 -4.75609  1.000 10.06559 ? 190 ILE A N   1 
ATOM   1458 C  CA  . ILE A 1 190 ? -22.30877 18.30565 -5.01988  1.000 11.17218 ? 190 ILE A CA  1 
ATOM   1459 C  C   . ILE A 1 190 ? -22.50940 16.88461 -5.51524  1.000 12.11184 ? 190 ILE A C   1 
ATOM   1460 O  O   . ILE A 1 190 ? -23.28597 16.11594 -4.92652  1.000 11.03170 ? 190 ILE A O   1 
ATOM   1461 C  CB  . ILE A 1 190 ? -21.39215 18.34334 -3.78913  1.000 6.34119  ? 190 ILE A CB  1 
ATOM   1462 C  CG1 . ILE A 1 190 ? -20.03019 17.72348 -4.12049  1.000 9.66154  ? 190 ILE A CG1 1 
ATOM   1463 C  CG2 . ILE A 1 190 ? -22.01686 17.65961 -2.58313  1.000 11.54755 ? 190 ILE A CG2 1 
ATOM   1464 C  CD1 . ILE A 1 190 ? -18.94346 18.15441 -3.14038  1.000 12.12473 ? 190 ILE A CD1 1 
ATOM   1465 N  N   . VAL A 1 191 ? -21.84525 16.56076 -6.62178  1.000 9.89759  ? 191 VAL A N   1 
ATOM   1466 C  CA  . VAL A 1 191 ? -21.98149 15.29505 -7.33085  1.000 10.65989 ? 191 VAL A CA  1 
ATOM   1467 C  C   . VAL A 1 191 ? -20.63784 14.57697 -7.27570  1.000 9.86618  ? 191 VAL A C   1 
ATOM   1468 O  O   . VAL A 1 191 ? -19.59091 15.19493 -7.50209  1.000 13.44806 ? 191 VAL A O   1 
ATOM   1469 C  CB  . VAL A 1 191 ? -22.40554 15.53218 -8.80059  1.000 13.16109 ? 191 VAL A CB  1 
ATOM   1470 C  CG1 . VAL A 1 191 ? -22.20167 14.27697 -9.63707  1.000 12.18810 ? 191 VAL A CG1 1 
ATOM   1471 C  CG2 . VAL A 1 191 ? -23.83277 16.02354 -8.89459  1.000 12.47368 ? 191 VAL A CG2 1 
ATOM   1472 N  N   . PHE A 1 192 ? -20.67010 13.27461 -6.99142  1.000 9.51565  ? 192 PHE A N   1 
ATOM   1473 C  CA  . PHE A 1 192 ? -19.52236 12.38076 -7.10022  1.000 11.91507 ? 192 PHE A CA  1 
ATOM   1474 C  C   . PHE A 1 192 ? -19.89924 11.29550 -8.08880  1.000 10.99424 ? 192 PHE A C   1 
ATOM   1475 O  O   . PHE A 1 192 ? -21.05742 10.86524 -8.12548  1.000 12.02431 ? 192 PHE A O   1 
ATOM   1476 C  CB  . PHE A 1 192 ? -19.19273 11.73980 -5.75793  1.000 10.77164 ? 192 PHE A CB  1 
ATOM   1477 C  CG  . PHE A 1 192 ? -18.44139 12.63552 -4.85033  1.000 13.90084 ? 192 PHE A CG  1 
ATOM   1478 C  CD1 . PHE A 1 192 ? -19.10701 13.59136 -4.11361  1.000 19.28236 ? 192 PHE A CD1 1 
ATOM   1479 C  CD2 . PHE A 1 192 ? -17.07130 12.49269 -4.69799  1.000 18.40730 ? 192 PHE A CD2 1 
ATOM   1480 C  CE1 . PHE A 1 192 ? -18.40096 14.42669 -3.26462  1.000 18.49998 ? 192 PHE A CE1 1 
ATOM   1481 C  CE2 . PHE A 1 192 ? -16.37581 13.32056 -3.85734  1.000 19.99095 ? 192 PHE A CE2 1 
ATOM   1482 C  CZ  . PHE A 1 192 ? -17.04259 14.29027 -3.14555  1.000 20.56772 ? 192 PHE A CZ  1 
ATOM   1483 N  N   . HIS A 1 193 ? -18.93744 10.85796 -8.89349  1.000 9.25205  ? 193 HIS A N   1 
ATOM   1484 C  CA  . HIS A 1 193 ? -19.21861 9.78139  -9.83184  1.000 10.48400 ? 193 HIS A CA  1 
ATOM   1485 C  C   . HIS A 1 193 ? -17.90120 9.18360  -10.29640 1.000 13.02083 ? 193 HIS A C   1 
ATOM   1486 O  O   . HIS A 1 193 ? -16.92721 9.90748  -10.51976 1.000 13.20985 ? 193 HIS A O   1 
ATOM   1487 C  CB  . HIS A 1 193 ? -20.05178 10.29161 -11.01479 1.000 12.79361 ? 193 HIS A CB  1 
ATOM   1488 C  CG  . HIS A 1 193 ? -21.11562 9.33228  -11.45455 1.000 12.73608 ? 193 HIS A CG  1 
ATOM   1489 N  ND1 . HIS A 1 193 ? -22.44349 9.68643  -11.52906 1.000 12.64475 ? 193 HIS A ND1 1 
ATOM   1490 C  CD2 . HIS A 1 193 ? -21.04146 8.05138  -11.88982 1.000 13.25285 ? 193 HIS A CD2 1 
ATOM   1491 C  CE1 . HIS A 1 193 ? -23.15309 8.64503  -11.93373 1.000 14.01340 ? 193 HIS A CE1 1 
ATOM   1492 N  NE2 . HIS A 1 193 ? -22.32348 7.64274  -12.17334 1.000 13.13065 ? 193 HIS A NE2 1 
ATOM   1493 N  N   . GLY A 1 194 ? -17.87286 7.85808  -10.39950 1.000 10.72400 ? 194 GLY A N   1 
ATOM   1494 C  CA  . GLY A 1 194 ? -16.69149 7.15189  -10.87090 1.000 12.43745 ? 194 GLY A CA  1 
ATOM   1495 C  C   . GLY A 1 194 ? -16.73337 6.98079  -12.38258 1.000 14.42452 ? 194 GLY A C   1 
ATOM   1496 O  O   . GLY A 1 194 ? -17.77462 6.68004  -12.95720 1.000 12.73099 ? 194 GLY A O   1 
ATOM   1497 N  N   . THR A 1 195 ? -15.57910 7.17693  -13.02408 1.000 15.10112 ? 195 THR A N   1 
ATOM   1498 C  CA  . THR A 1 195 ? -15.55592 7.09885  -14.48135 1.000 16.49612 ? 195 THR A CA  1 
ATOM   1499 C  C   . THR A 1 195 ? -15.64856 5.67080  -14.99986 1.000 16.95365 ? 195 THR A C   1 
ATOM   1500 O  O   . THR A 1 195 ? -15.98274 5.48606  -16.17212 1.000 20.08840 ? 195 THR A O   1 
ATOM   1501 C  CB  . THR A 1 195 ? -14.30490 7.77102  -15.05929 1.000 14.51010 ? 195 THR A CB  1 
ATOM   1502 O  OG1 . THR A 1 195 ? -13.12335 7.06050  -14.66111 1.000 16.83424 ? 195 THR A OG1 1 
ATOM   1503 C  CG2 . THR A 1 195 ? -14.22641 9.24978  -14.61173 1.000 17.98450 ? 195 THR A CG2 1 
ATOM   1504 N  N   . SER A 1 196 ? -15.36393 4.66144  -14.16947 1.000 18.67365 ? 196 SER A N   1 
ATOM   1505 C  CA  . SER A 1 196 ? -15.55282 3.26073  -14.54139 1.000 19.70512 ? 196 SER A CA  1 
ATOM   1506 C  C   . SER A 1 196 ? -16.76958 2.65489  -13.83851 1.000 26.63229 ? 196 SER A C   1 
ATOM   1507 O  O   . SER A 1 196 ? -16.78600 1.46703  -13.48715 1.000 17.89932 ? 196 SER A O   1 
ATOM   1508 C  CB  . SER A 1 196 ? -14.29086 2.45347  -14.24567 1.000 20.53875 ? 196 SER A CB  1 
ATOM   1509 O  OG  . SER A 1 196 ? -13.18125 3.01388  -14.94901 1.000 19.50903 ? 196 SER A OG  1 
ATOM   1510 N  N   . ASP A 1 197 ? -17.79016 3.47286  -13.60518 1.000 16.57900 ? 197 ASP A N   1 
ATOM   1511 C  CA  . ASP A 1 197 ? -19.05087 2.97076  -13.07338 1.000 15.19089 ? 197 ASP A CA  1 
ATOM   1512 C  C   . ASP A 1 197 ? -19.80469 2.22095  -14.16836 1.000 19.00205 ? 197 ASP A C   1 
ATOM   1513 O  O   . ASP A 1 197 ? -20.20614 2.82804  -15.16801 1.000 18.36925 ? 197 ASP A O   1 
ATOM   1514 C  CB  . ASP A 1 197 ? -19.87551 4.14243  -12.55299 1.000 14.99381 ? 197 ASP A CB  1 
ATOM   1515 C  CG  . ASP A 1 197 ? -21.04746 3.71157  -11.69394 1.000 18.17578 ? 197 ASP A CG  1 
ATOM   1516 O  OD1 . ASP A 1 197 ? -21.58930 2.59747  -11.89665 1.000 16.37940 ? 197 ASP A OD1 1 
ATOM   1517 O  OD2 . ASP A 1 197 ? -21.40522 4.49339  -10.77727 1.000 15.26213 ? 197 ASP A OD2 1 
ATOM   1518 N  N   . TYR A 1 198 ? -20.00364 0.90836  -13.98134 1.000 19.22626 ? 198 TYR A N   1 
ATOM   1519 C  CA  . TYR A 1 198 ? -20.77141 0.07292  -14.90687 1.000 26.50677 ? 198 TYR A CA  1 
ATOM   1520 C  C   . TYR A 1 198 ? -22.17966 -0.19265 -14.41410 1.000 29.23086 ? 198 TYR A C   1 
ATOM   1521 O  O   . TYR A 1 198 ? -22.89635 -0.99855 -15.01924 1.000 26.22522 ? 198 TYR A O   1 
ATOM   1522 C  CB  . TYR A 1 198 ? -20.08101 -1.27955 -15.16058 1.000 20.28304 ? 198 TYR A CB  1 
ATOM   1523 C  CG  . TYR A 1 198 ? -18.67641 -1.16741 -15.69536 1.000 22.19936 ? 198 TYR A CG  1 
ATOM   1524 C  CD1 . TYR A 1 198 ? -18.44465 -0.80092 -17.01226 1.000 21.26191 ? 198 TYR A CD1 1 
ATOM   1525 C  CD2 . TYR A 1 198 ? -17.58236 -1.43573 -14.88505 1.000 19.11958 ? 198 TYR A CD2 1 
ATOM   1526 C  CE1 . TYR A 1 198 ? -17.14969 -0.67416 -17.50419 1.000 20.99169 ? 198 TYR A CE1 1 
ATOM   1527 C  CE2 . TYR A 1 198 ? -16.30050 -1.33158 -15.36882 1.000 18.13817 ? 198 TYR A CE2 1 
ATOM   1528 C  CZ  . TYR A 1 198 ? -16.08860 -0.94982 -16.67932 1.000 25.52787 ? 198 TYR A CZ  1 
ATOM   1529 O  OH  . TYR A 1 198 ? -14.80603 -0.83899 -17.15356 1.000 32.62883 ? 198 TYR A OH  1 
ATOM   1530 N  N   . THR A 1 199 ? -22.57835 0.42729  -13.30692 1.000 17.11864 ? 199 THR A N   1 
ATOM   1531 C  CA  . THR A 1 199 ? -23.93422 0.29493  -12.79423 1.000 18.28677 ? 199 THR A CA  1 
ATOM   1532 C  C   . THR A 1 199 ? -24.78208 1.49739  -13.19000 1.000 24.31171 ? 199 THR A C   1 
ATOM   1533 O  O   . THR A 1 199 ? -25.74598 1.36028  -13.94769 1.000 19.68384 ? 199 THR A O   1 
ATOM   1534 C  CB  . THR A 1 199 ? -23.91707 0.11446  -11.26071 1.000 18.57913 ? 199 THR A CB  1 
ATOM   1535 O  OG1 . THR A 1 199 ? -23.12155 -1.03183 -10.92581 1.000 19.90744 ? 199 THR A OG1 1 
ATOM   1536 C  CG2 . THR A 1 199 ? -25.33002 -0.08803 -10.71655 1.000 23.08014 ? 199 THR A CG2 1 
ATOM   1537 N  N   . VAL A 1 200 ? -24.42081 2.67732  -12.69722 1.000 14.86504 ? 200 VAL A N   1 
ATOM   1538 C  CA  . VAL A 1 200 ? -25.00747 3.94228  -13.12013 1.000 11.97213 ? 200 VAL A CA  1 
ATOM   1539 C  C   . VAL A 1 200 ? -23.89745 4.65553  -13.87615 1.000 14.89840 ? 200 VAL A C   1 
ATOM   1540 O  O   . VAL A 1 200 ? -22.93425 5.13776  -13.26662 1.000 14.07479 ? 200 VAL A O   1 
ATOM   1541 C  CB  . VAL A 1 200 ? -25.50898 4.75784  -11.92393 1.000 15.29334 ? 200 VAL A CB  1 
ATOM   1542 C  CG1 . VAL A 1 200 ? -26.01059 6.14479  -12.36202 1.000 12.25809 ? 200 VAL A CG1 1 
ATOM   1543 C  CG2 . VAL A 1 200 ? -26.57970 3.98104  -11.15224 1.000 10.99342 ? 200 VAL A CG2 1 
ATOM   1544 N  N   A TYR A 1 201 ? -24.00748 4.68817  -15.20609 0.411 15.39451 ? 201 TYR A N   1 
ATOM   1545 N  N   B TYR A 1 201 ? -24.02272 4.73125  -15.19790 0.589 15.38388 ? 201 TYR A N   1 
ATOM   1546 C  CA  A TYR A 1 201 ? -22.92014 5.20498  -16.01958 0.411 14.08080 ? 201 TYR A CA  1 
ATOM   1547 C  CA  B TYR A 1 201 ? -22.90417 5.19556  -15.99337 0.589 14.03012 ? 201 TYR A CA  1 
ATOM   1548 C  C   A TYR A 1 201 ? -22.66432 6.67158  -15.68179 0.411 13.85332 ? 201 TYR A C   1 
ATOM   1549 C  C   B TYR A 1 201 ? -22.68685 6.69369  -15.78293 0.589 13.83106 ? 201 TYR A C   1 
ATOM   1550 O  O   A TYR A 1 201 ? -23.55799 7.37123  -15.19941 0.411 14.31147 ? 201 TYR A O   1 
ATOM   1551 O  O   B TYR A 1 201 ? -23.62789 7.43102  -15.48747 0.589 14.78102 ? 201 TYR A O   1 
ATOM   1552 C  CB  A TYR A 1 201 ? -23.22603 5.04776  -17.50943 0.411 16.90740 ? 201 TYR A CB  1 
ATOM   1553 C  CB  B TYR A 1 201 ? -23.12776 4.86618  -17.46624 0.589 17.30770 ? 201 TYR A CB  1 
ATOM   1554 C  CG  A TYR A 1 201 ? -22.53117 3.85346  -18.13419 0.411 16.90519 ? 201 TYR A CG  1 
ATOM   1555 C  CG  B TYR A 1 201 ? -22.77556 3.41720  -17.75610 0.589 17.36547 ? 201 TYR A CG  1 
ATOM   1556 C  CD1 A TYR A 1 201 ? -22.81299 2.56146  -17.71058 0.411 20.14401 ? 201 TYR A CD1 1 
ATOM   1557 C  CD1 B TYR A 1 201 ? -23.51421 2.37459  -17.19024 0.589 16.09128 ? 201 TYR A CD1 1 
ATOM   1558 C  CD2 A TYR A 1 201 ? -21.57220 4.02181  -19.12601 0.411 17.60447 ? 201 TYR A CD2 1 
ATOM   1559 C  CD2 B TYR A 1 201 ? -21.68171 3.08849  -18.54751 0.589 22.03608 ? 201 TYR A CD2 1 
ATOM   1560 C  CE1 A TYR A 1 201 ? -22.16726 1.46465  -18.26595 0.411 21.36664 ? 201 TYR A CE1 1 
ATOM   1561 C  CE1 B TYR A 1 201 ? -23.18470 1.04339  -17.42839 0.589 18.24111 ? 201 TYR A CE1 1 
ATOM   1562 C  CE2 A TYR A 1 201 ? -20.92662 2.93355  -19.69079 0.411 20.03525 ? 201 TYR A CE2 1 
ATOM   1563 C  CE2 B TYR A 1 201 ? -21.34183 1.76077  -18.78708 0.589 21.71897 ? 201 TYR A CE2 1 
ATOM   1564 C  CZ  A TYR A 1 201 ? -21.22711 1.65850  -19.25891 0.411 21.37321 ? 201 TYR A CZ  1 
ATOM   1565 C  CZ  B TYR A 1 201 ? -22.09448 0.74390  -18.22310 0.589 19.22207 ? 201 TYR A CZ  1 
ATOM   1566 O  OH  A TYR A 1 201 ? -20.57947 0.57581  -19.81522 0.411 21.37706 ? 201 TYR A OH  1 
ATOM   1567 O  OH  B TYR A 1 201 ? -21.76347 -0.57583 -18.46985 0.589 22.74463 ? 201 TYR A OH  1 
ATOM   1568 N  N   . PRO A 1 202 ? -21.44440 7.16060  -15.91074 1.000 14.48444 ? 202 PRO A N   1 
ATOM   1569 C  CA  . PRO A 1 202 ? -21.12302 8.52975  -15.48550 1.000 11.53038 ? 202 PRO A CA  1 
ATOM   1570 C  C   . PRO A 1 202 ? -21.87119 9.61638  -16.24824 1.000 15.76729 ? 202 PRO A C   1 
ATOM   1571 O  O   . PRO A 1 202 ? -21.93943 10.75036 -15.75994 1.000 15.16160 ? 202 PRO A O   1 
ATOM   1572 C  CB  . PRO A 1 202 ? -19.60597 8.62030  -15.70623 1.000 17.01739 ? 202 PRO A CB  1 
ATOM   1573 C  CG  . PRO A 1 202 ? -19.25141 7.47100  -16.57981 1.000 18.09683 ? 202 PRO A CG  1 
ATOM   1574 C  CD  . PRO A 1 202 ? -20.26417 6.40374  -16.36292 1.000 17.98171 ? 202 PRO A CD  1 
ATOM   1575 N  N   . VAL A 1 203 ? -22.43701 9.31436  -17.41809 1.000 15.55165 ? 203 VAL A N   1 
ATOM   1576 C  CA  . VAL A 1 203 ? -23.28384 10.29797 -18.08209 1.000 14.13326 ? 203 VAL A CA  1 
ATOM   1577 C  C   . VAL A 1 203 ? -24.30984 10.83138 -17.10743 1.000 17.89358 ? 203 VAL A C   1 
ATOM   1578 O  O   . VAL A 1 203 ? -24.71425 12.00115 -17.17887 1.000 12.87635 ? 203 VAL A O   1 
ATOM   1579 C  CB  . VAL A 1 203 ? -23.96427 9.68355  -19.31301 1.000 14.69808 ? 203 VAL A CB  1 
ATOM   1580 C  CG1 . VAL A 1 203 ? -24.77116 8.43494  -18.91389 1.000 18.40163 ? 203 VAL A CG1 1 
ATOM   1581 C  CG2 . VAL A 1 203 ? -24.88037 10.71459 -19.95437 1.000 19.46575 ? 203 VAL A CG2 1 
ATOM   1582 N  N   . ASN A 1 204 ? -24.73498 9.99173  -16.16473 1.000 11.60964 ? 204 ASN A N   1 
ATOM   1583 C  CA  . ASN A 1 204 ? -25.74500 10.42983 -15.21198 1.000 11.16246 ? 204 ASN A CA  1 
ATOM   1584 C  C   . ASN A 1 204 ? -25.19399 11.50130 -14.27903 1.000 11.21529 ? 204 ASN A C   1 
ATOM   1585 O  O   . ASN A 1 204 ? -25.90649 12.44334 -13.91978 1.000 11.12850 ? 204 ASN A O   1 
ATOM   1586 C  CB  . ASN A 1 204 ? -26.25310 9.20850  -14.45231 1.000 10.43262 ? 204 ASN A CB  1 
ATOM   1587 C  CG  . ASN A 1 204 ? -27.18752 8.36605  -15.30842 1.000 13.77130 ? 204 ASN A CG  1 
ATOM   1588 O  OD1 . ASN A 1 204 ? -28.30270 8.79510  -15.60629 1.000 14.50879 ? 204 ASN A OD1 1 
ATOM   1589 N  ND2 . ASN A 1 204 ? -26.72365 7.19036  -15.74406 1.000 10.51380 ? 204 ASN A ND2 1 
ATOM   1590 N  N   . GLY A 1 205 ? -23.93134 11.36554 -13.86459 1.000 9.73848  ? 205 GLY A N   1 
ATOM   1591 C  CA  . GLY A 1 205 ? -23.32079 12.40249 -13.04102 1.000 13.33333 ? 205 GLY A CA  1 
ATOM   1592 C  C   . GLY A 1 205 ? -23.27980 13.73748 -13.75575 1.000 11.73087 ? 205 GLY A C   1 
ATOM   1593 O  O   . GLY A 1 205 ? -23.63431 14.77638 -13.18925 1.000 9.10894  ? 205 GLY A O   1 
ATOM   1594 N  N   . HIS A 1 206 ? -22.90088 13.72215 -15.02992 1.000 11.43813 ? 206 HIS A N   1 
ATOM   1595 C  CA  . HIS A 1 206 ? -22.92200 14.95531 -15.80433 1.000 13.76887 ? 206 HIS A CA  1 
ATOM   1596 C  C   . HIS A 1 206 ? -24.33677 15.51842 -15.91213 1.000 17.59583 ? 206 HIS A C   1 
ATOM   1597 O  O   . HIS A 1 206 ? -24.53930 16.73578 -15.79602 1.000 11.25521 ? 206 HIS A O   1 
ATOM   1598 C  CB  . HIS A 1 206 ? -22.31124 14.69451 -17.17904 1.000 14.37326 ? 206 HIS A CB  1 
ATOM   1599 C  CG  . HIS A 1 206 ? -20.94382 14.08763 -17.11496 1.000 13.01741 ? 206 HIS A CG  1 
ATOM   1600 N  ND1 . HIS A 1 206 ? -19.90680 14.67799 -16.43276 1.000 15.61302 ? 206 HIS A ND1 1 
ATOM   1601 C  CD2 . HIS A 1 206 ? -20.45534 12.92746 -17.61269 1.000 17.20466 ? 206 HIS A CD2 1 
ATOM   1602 C  CE1 . HIS A 1 206 ? -18.82643 13.92327 -16.53290 1.000 18.61992 ? 206 HIS A CE1 1 
ATOM   1603 N  NE2 . HIS A 1 206 ? -19.13285 12.85076 -17.23966 1.000 16.35211 ? 206 HIS A NE2 1 
ATOM   1604 N  N   . GLN A 1 207 ? -25.33362 14.64704 -16.11337 1.000 14.53883 ? 207 GLN A N   1 
ATOM   1605 C  CA  . GLN A 1 207 ? -26.70720 15.11731 -16.26218 1.000 12.48231 ? 207 GLN A CA  1 
ATOM   1606 C  C   . GLN A 1 207 ? -27.22667 15.75103 -14.97734 1.000 10.86188 ? 207 GLN A C   1 
ATOM   1607 O  O   . GLN A 1 207 ? -27.94328 16.75808 -15.02529 1.000 11.13579 ? 207 GLN A O   1 
ATOM   1608 C  CB  . GLN A 1 207 ? -27.61762 13.96154 -16.67692 1.000 10.84410 ? 207 GLN A CB  1 
ATOM   1609 C  CG  . GLN A 1 207 ? -27.48063 13.55041 -18.13591 1.000 14.42472 ? 207 GLN A CG  1 
ATOM   1610 C  CD  . GLN A 1 207 ? -28.64075 12.68278 -18.59137 1.000 11.53228 ? 207 GLN A CD  1 
ATOM   1611 O  OE1 . GLN A 1 207 ? -29.21219 11.94158 -17.79912 1.000 16.52913 ? 207 GLN A OE1 1 
ATOM   1612 N  NE2 . GLN A 1 207 ? -29.02326 12.80932 -19.86430 1.000 17.04054 ? 207 GLN A NE2 1 
ATOM   1613 N  N   . VAL A 1 208 ? -26.88704 15.17562 -13.81602 1.000 11.31783 ? 208 VAL A N   1 
ATOM   1614 C  CA  . VAL A 1 208 ? -27.33683 15.76760 -12.55802 1.000 11.86128 ? 208 VAL A CA  1 
ATOM   1615 C  C   . VAL A 1 208 ? -26.93131 17.23633 -12.50121 1.000 12.00249 ? 208 VAL A C   1 
ATOM   1616 O  O   . VAL A 1 208 ? -27.72503 18.11064 -12.13444 1.000 10.80126 ? 208 VAL A O   1 
ATOM   1617 C  CB  . VAL A 1 208 ? -26.77750 14.98323 -11.35825 1.000 11.34545 ? 208 VAL A CB  1 
ATOM   1618 C  CG1 . VAL A 1 208 ? -27.02956 15.76010 -10.02908 1.000 12.01287 ? 208 VAL A CG1 1 
ATOM   1619 C  CG2 . VAL A 1 208 ? -27.41543 13.59768 -11.26640 1.000 10.32583 ? 208 VAL A CG2 1 
ATOM   1620 N  N   . ILE A 1 209 ? -25.67493 17.52142 -12.84734 1.000 12.95668 ? 209 ILE A N   1 
ATOM   1621 C  CA  . ILE A 1 209 ? -25.20412 18.90397 -12.84419 1.000 11.13777 ? 209 ILE A CA  1 
ATOM   1622 C  C   . ILE A 1 209 ? -25.97739 19.72844 -13.86092 1.000 9.95833  ? 209 ILE A C   1 
ATOM   1623 O  O   . ILE A 1 209 ? -26.41692 20.84254 -13.57212 1.000 10.66501 ? 209 ILE A O   1 
ATOM   1624 C  CB  . ILE A 1 209 ? -23.69108 18.96483 -13.10614 1.000 11.62767 ? 209 ILE A CB  1 
ATOM   1625 C  CG1 . ILE A 1 209 ? -22.91495 18.43613 -11.89432 1.000 12.77630 ? 209 ILE A CG1 1 
ATOM   1626 C  CG2 . ILE A 1 209 ? -23.28951 20.40191 -13.40513 1.000 11.02769 ? 209 ILE A CG2 1 
ATOM   1627 C  CD1 . ILE A 1 209 ? -23.01600 19.30951 -10.63853 1.000 11.41372 ? 209 ILE A CD1 1 
ATOM   1628 N  N   . SER A 1 210 ? -26.16687 19.19458 -15.06587 1.000 10.27371 ? 210 SER A N   1 
ATOM   1629 C  CA  . SER A 1 210 ? -26.84611 19.99397 -16.08239 1.000 11.13121 ? 210 SER A CA  1 
ATOM   1630 C  C   . SER A 1 210 ? -28.30548 20.22536 -15.71535 1.000 15.14657 ? 210 SER A C   1 
ATOM   1631 O  O   . SER A 1 210 ? -28.83689 21.31547 -15.93564 1.000 13.48645 ? 210 SER A O   1 
ATOM   1632 C  CB  . SER A 1 210 ? -26.72799 19.32028 -17.45035 1.000 12.95996 ? 210 SER A CB  1 
ATOM   1633 O  OG  . SER A 1 210 ? -25.36503 19.33891 -17.84403 1.000 16.01353 ? 210 SER A OG  1 
ATOM   1634 N  N   . GLN A 1 211 ? -28.95496 19.21864 -15.13470 1.000 10.25209 ? 211 GLN A N   1 
ATOM   1635 C  CA  . GLN A 1 211 ? -30.33569 19.36682 -14.68759 1.000 8.35250  ? 211 GLN A CA  1 
ATOM   1636 C  C   . GLN A 1 211 ? -30.44247 20.40259 -13.57205 1.000 8.09601  ? 211 GLN A C   1 
ATOM   1637 O  O   . GLN A 1 211 ? -31.35155 21.23736 -13.57622 1.000 11.52182 ? 211 GLN A O   1 
ATOM   1638 C  CB  . GLN A 1 211 ? -30.86596 18.00149 -14.22079 1.000 11.25502 ? 211 GLN A CB  1 
ATOM   1639 C  CG  . GLN A 1 211 ? -32.30363 18.00251 -13.63756 1.000 10.84886 ? 211 GLN A CG  1 
ATOM   1640 C  CD  . GLN A 1 211 ? -32.30488 17.91124 -12.12605 1.000 11.07605 ? 211 GLN A CD  1 
ATOM   1641 O  OE1 . GLN A 1 211 ? -32.00231 16.85868 -11.55637 1.000 12.32273 ? 211 GLN A OE1 1 
ATOM   1642 N  NE2 . GLN A 1 211 ? -32.58771 19.02449 -11.46835 1.000 8.29302  ? 211 GLN A NE2 1 
ATOM   1643 N  N   . TRP A 1 212 ? -29.51778 20.37847 -12.61408 1.000 9.49812  ? 212 TRP A N   1 
ATOM   1644 C  CA  . TRP A 1 212 ? -29.63082 21.31799 -11.50518 1.000 9.37753  ? 212 TRP A CA  1 
ATOM   1645 C  C   . TRP A 1 212 ? -29.19977 22.72404 -11.90617 1.000 11.20340 ? 212 TRP A C   1 
ATOM   1646 O  O   . TRP A 1 212 ? -29.68076 23.69799 -11.32298 1.000 9.35316  ? 212 TRP A O   1 
ATOM   1647 C  CB  . TRP A 1 212 ? -28.83053 20.80509 -10.30614 1.000 8.97257  ? 212 TRP A CB  1 
ATOM   1648 C  CG  . TRP A 1 212 ? -29.68962 19.86721 -9.54319  1.000 10.98112 ? 212 TRP A CG  1 
ATOM   1649 C  CD1 . TRP A 1 212 ? -29.67690 18.50547 -9.59853  1.000 10.72187 ? 212 TRP A CD1 1 
ATOM   1650 C  CD2 . TRP A 1 212 ? -30.77841 20.23313 -8.68112  1.000 10.43300 ? 212 TRP A CD2 1 
ATOM   1651 N  NE1 . TRP A 1 212 ? -30.67062 17.99759 -8.77961  1.000 11.45078 ? 212 TRP A NE1 1 
ATOM   1652 C  CE2 . TRP A 1 212 ? -31.36324 19.04241 -8.21783  1.000 12.56582 ? 212 TRP A CE2 1 
ATOM   1653 C  CE3 . TRP A 1 212 ? -31.30282 21.46263 -8.24825  1.000 10.88005 ? 212 TRP A CE3 1 
ATOM   1654 C  CZ2 . TRP A 1 212 ? -32.45168 19.03494 -7.33293  1.000 11.10169 ? 212 TRP A CZ2 1 
ATOM   1655 C  CZ3 . TRP A 1 212 ? -32.38958 21.45580 -7.35086  1.000 11.01419 ? 212 TRP A CZ3 1 
ATOM   1656 C  CH2 . TRP A 1 212 ? -32.95242 20.25125 -6.92263  1.000 9.91699  ? 212 TRP A CH2 1 
ATOM   1657 N  N   . ALA A 1 213 ? -28.31562 22.85360 -12.90096 1.000 9.19029  ? 213 ALA A N   1 
ATOM   1658 C  CA  . ALA A 1 213 ? -28.06067 24.17787 -13.46699 1.000 11.36435 ? 213 ALA A CA  1 
ATOM   1659 C  C   . ALA A 1 213 ? -29.36650 24.84488 -13.89228 1.000 11.09790 ? 213 ALA A C   1 
ATOM   1660 O  O   . ALA A 1 213 ? -29.63443 25.99280 -13.53568 1.000 12.43964 ? 213 ALA A O   1 
ATOM   1661 C  CB  . ALA A 1 213 ? -27.09550 24.08024 -14.65739 1.000 10.43608 ? 213 ALA A CB  1 
ATOM   1662 N  N   . GLN A 1 214 ? -30.19465 24.13033 -14.65642 1.000 12.18843 ? 214 GLN A N   1 
ATOM   1663 C  CA  . GLN A 1 214 ? -31.46267 24.69202 -15.10957 1.000 12.28112 ? 214 GLN A CA  1 
ATOM   1664 C  C   . GLN A 1 214 ? -32.41063 24.94895 -13.94049 1.000 10.90506 ? 214 GLN A C   1 
ATOM   1665 O  O   . GLN A 1 214 ? -32.99928 26.03047 -13.82755 1.000 14.42693 ? 214 GLN A O   1 
ATOM   1666 C  CB  . GLN A 1 214 ? -32.11877 23.74150 -16.10106 1.000 14.70774 ? 214 GLN A CB  1 
ATOM   1667 C  CG  . GLN A 1 214 ? -33.47996 24.21884 -16.63129 1.000 16.73860 ? 214 GLN A CG  1 
ATOM   1668 C  CD  . GLN A 1 214 ? -33.36961 25.49714 -17.44584 1.000 19.68784 ? 214 GLN A CD  1 
ATOM   1669 O  OE1 . GLN A 1 214 ? -32.27262 25.90153 -17.83180 1.000 17.72699 ? 214 GLN A OE1 1 
ATOM   1670 N  NE2 . GLN A 1 214 ? -34.51516 26.07461 -17.80320 1.000 17.47937 ? 214 GLN A NE2 1 
ATOM   1671 N  N   . THR A 1 215 ? -32.60557 23.94233 -13.08218 1.000 14.37402 ? 215 THR A N   1 
ATOM   1672 C  CA  . THR A 1 215 ? -33.50241 24.11295 -11.94337 1.000 11.21174 ? 215 THR A CA  1 
ATOM   1673 C  C   . THR A 1 215 ? -33.07634 25.30281 -11.08662 1.000 15.19362 ? 215 THR A C   1 
ATOM   1674 O  O   . THR A 1 215 ? -33.89844 26.15690 -10.72847 1.000 16.25826 ? 215 THR A O   1 
ATOM   1675 C  CB  . THR A 1 215 ? -33.53413 22.83407 -11.10706 1.000 12.52775 ? 215 THR A CB  1 
ATOM   1676 O  OG1 . THR A 1 215 ? -33.84425 21.71939 -11.95244 1.000 10.72282 ? 215 THR A OG1 1 
ATOM   1677 C  CG2 . THR A 1 215 ? -34.58067 22.95840 -9.98773  1.000 14.25355 ? 215 THR A CG2 1 
ATOM   1678 N  N   . ASN A 1 216 ? -31.78593 25.39061 -10.76750 1.000 12.85962 ? 216 ASN A N   1 
ATOM   1679 C  CA  . ASN A 1 216 ? -31.32438 26.48302 -9.91847  1.000 10.63328 ? 216 ASN A CA  1 
ATOM   1680 C  C   . ASN A 1 216 ? -31.35613 27.81616 -10.65411 1.000 15.96542 ? 216 ASN A C   1 
ATOM   1681 O  O   . ASN A 1 216 ? -31.62558 28.85963 -10.04549 1.000 14.93660 ? 216 ASN A O   1 
ATOM   1682 C  CB  . ASN A 1 216 ? -29.92482 26.18324 -9.39534  1.000 13.74756 ? 216 ASN A CB  1 
ATOM   1683 C  CG  . ASN A 1 216 ? -29.94592 25.12745 -8.30045  1.000 13.19845 ? 216 ASN A CG  1 
ATOM   1684 O  OD1 . ASN A 1 216 ? -30.96530 24.94037 -7.65347  1.000 15.05049 ? 216 ASN A OD1 1 
ATOM   1685 N  ND2 . ASN A 1 216 ? -28.83798 24.42334 -8.10918  1.000 10.13296 ? 216 ASN A ND2 1 
ATOM   1686 N  N   . ASP A 1 217 ? -31.08889 27.81262 -11.95526 1.000 14.19123 ? 217 ASP A N   1 
ATOM   1687 C  CA  . ASP A 1 217 ? -31.28310 29.04276 -12.71200 1.000 16.14457 ? 217 ASP A CA  1 
ATOM   1688 C  C   . ASP A 1 217 ? -32.74128 29.48599 -12.65334 1.000 21.56354 ? 217 ASP A C   1 
ATOM   1689 O  O   . ASP A 1 217 ? -33.03052 30.66938 -12.43842 1.000 14.12611 ? 217 ASP A O   1 
ATOM   1690 C  CB  . ASP A 1 217 ? -30.83502 28.85406 -14.16020 1.000 11.36007 ? 217 ASP A CB  1 
ATOM   1691 C  CG  . ASP A 1 217 ? -30.69549 30.17507 -14.88782 1.000 19.19828 ? 217 ASP A CG  1 
ATOM   1692 O  OD1 . ASP A 1 217 ? -29.92225 31.03221 -14.41526 1.000 19.12756 ? 217 ASP A OD1 1 
ATOM   1693 O  OD2 . ASP A 1 217 ? -31.39432 30.36745 -15.90235 1.000 22.43985 ? 217 ASP A OD2 1 
ATOM   1694 N  N   . ARG A 1 218 ? -33.67973 28.54380 -12.81152 1.000 14.98726 ? 218 ARG A N   1 
ATOM   1695 C  CA  . ARG A 1 218 ? -35.09502 28.91267 -12.74110 1.000 18.97723 ? 218 ARG A CA  1 
ATOM   1696 C  C   . ARG A 1 218 ? -35.51189 29.34590 -11.34404 1.000 19.58314 ? 218 ARG A C   1 
ATOM   1697 O  O   . ARG A 1 218 ? -36.38379 30.21560 -11.20828 1.000 19.42109 ? 218 ARG A O   1 
ATOM   1698 C  CB  . ARG A 1 218 ? -35.98391 27.75416 -13.19082 1.000 13.76478 ? 218 ARG A CB  1 
ATOM   1699 C  CG  . ARG A 1 218 ? -35.66049 27.27120 -14.58620 1.000 14.57899 ? 218 ARG A CG  1 
ATOM   1700 C  CD  . ARG A 1 218 ? -36.41060 28.03270 -15.68914 1.000 20.25934 ? 218 ARG A CD  1 
ATOM   1701 N  NE  . ARG A 1 218 ? -37.73975 28.51592 -15.32273 1.000 20.13866 ? 218 ARG A NE  1 
ATOM   1702 C  CZ  . ARG A 1 218 ? -38.86573 27.91809 -15.69664 1.000 21.41100 ? 218 ARG A CZ  1 
ATOM   1703 N  NH1 . ARG A 1 218 ? -38.85071 26.77939 -16.37008 1.000 21.24764 ? 218 ARG A NH1 1 
ATOM   1704 N  NH2 . ARG A 1 218 ? -40.03575 28.45351 -15.35125 1.000 23.36873 ? 218 ARG A NH2 1 
ATOM   1705 N  N   . ALA A 1 219 ? -34.94176 28.73504 -10.29477 1.000 11.86966 ? 219 ALA A N   1 
ATOM   1706 C  CA  . ALA A 1 219 ? -35.33768 29.11203 -8.94195  1.000 16.85732 ? 219 ALA A CA  1 
ATOM   1707 C  C   . ALA A 1 219 ? -34.90046 30.53216 -8.59708  1.000 22.48751 ? 219 ALA A C   1 
ATOM   1708 O  O   . ALA A 1 219 ? -35.45751 31.13144 -7.67459  1.000 24.51566 ? 219 ALA A O   1 
ATOM   1709 C  CB  . ALA A 1 219 ? -34.76854 28.12529 -7.90799  1.000 18.72028 ? 219 ALA A CB  1 
ATOM   1710 N  N   . GLY A 1 220 ? -33.91175 31.07503 -9.30086  1.000 25.71427 ? 220 GLY A N   1 
ATOM   1711 C  CA  . GLY A 1 220 ? -33.53756 32.46150 -9.11240  1.000 36.87157 ? 220 GLY A CA  1 
ATOM   1712 C  C   . GLY A 1 220 ? -34.42471 33.48853 -9.78895  1.000 42.40559 ? 220 GLY A C   1 
ATOM   1713 O  O   . GLY A 1 220 ? -34.20889 34.68666 -9.59527  1.000 60.52273 ? 220 GLY A O   1 
ATOM   1714 N  N   . ASP A 1 221 ? -35.42430 33.07704 -10.56845 1.000 42.03287 ? 221 ASP A N   1 
ATOM   1715 C  CA  . ASP A 1 221 ? -36.23005 34.02459 -11.33149 1.000 45.59062 ? 221 ASP A CA  1 
ATOM   1716 C  C   . ASP A 1 221 ? -37.47952 34.42836 -10.55335 1.000 53.20662 ? 221 ASP A C   1 
ATOM   1717 O  O   . ASP A 1 221 ? -38.20830 33.57169 -10.03752 1.000 48.39151 ? 221 ASP A O   1 
ATOM   1718 C  CB  . ASP A 1 221 ? -36.64731 33.44142 -12.68140 1.000 42.12577 ? 221 ASP A CB  1 
ATOM   1719 C  CG  . ASP A 1 221 ? -35.46574 33.01417 -13.54142 1.000 42.31338 ? 221 ASP A CG  1 
ATOM   1720 O  OD1 . ASP A 1 221 ? -34.57404 33.84119 -13.85567 1.000 42.25830 ? 221 ASP A OD1 1 
ATOM   1721 O  OD2 . ASP A 1 221 ? -35.48024 31.84054 -13.95833 1.000 35.81120 ? 221 ASP A OD2 1 
ATOM   1722 N  N   . GLY A 1 222 ? -37.74010 35.73184 -10.50269 1.000 46.72328 ? 222 GLY A N   1 
ATOM   1723 C  CA  . GLY A 1 222 ? -38.90544 36.24603 -9.80226  1.000 46.11082 ? 222 GLY A CA  1 
ATOM   1724 C  C   . GLY A 1 222 ? -38.55700 36.83347 -8.44651  1.000 46.79511 ? 222 GLY A C   1 
ATOM   1725 O  O   . GLY A 1 222 ? -39.16027 37.81468 -8.00555  1.000 49.75895 ? 222 GLY A O   1 
ATOM   1726 N  N   . ASN A 1 225 ? -32.60864 36.70759 -10.82424 1.000 62.54214 ? 225 ASN A N   1 
ATOM   1727 C  CA  . ASN A 1 225 ? -31.58739 37.69874 -10.50707 1.000 61.28488 ? 225 ASN A CA  1 
ATOM   1728 C  C   . ASN A 1 225 ? -30.16354 37.15193 -10.67019 1.000 64.01483 ? 225 ASN A C   1 
ATOM   1729 O  O   . ASN A 1 225 ? -29.21750 37.91861 -10.88772 1.000 60.60763 ? 225 ASN A O   1 
ATOM   1730 C  CB  . ASN A 1 225 ? -31.77092 38.21802 -9.07510  1.000 55.93374 ? 225 ASN A CB  1 
ATOM   1731 C  CG  . ASN A 1 225 ? -32.27911 37.14744 -8.11822  1.000 63.59378 ? 225 ASN A CG  1 
ATOM   1732 O  OD1 . ASN A 1 225 ? -33.36078 36.59669 -8.30732  1.000 67.08859 ? 225 ASN A OD1 1 
ATOM   1733 N  ND2 . ASN A 1 225 ? -31.49176 36.84397 -7.08906  1.000 58.08378 ? 225 ASN A ND2 1 
ATOM   1734 N  N   . ASN A 1 226 ? -30.01372 35.82845 -10.57417 1.000 52.47527 ? 226 ASN A N   1 
ATOM   1735 C  CA  . ASN A 1 226 ? -28.70628 35.19874 -10.38655 1.000 40.80607 ? 226 ASN A CA  1 
ATOM   1736 C  C   . ASN A 1 226 ? -28.56444 34.04039 -11.37544 1.000 35.52800 ? 226 ASN A C   1 
ATOM   1737 O  O   . ASN A 1 226 ? -29.04543 32.93546 -11.10998 1.000 39.70194 ? 226 ASN A O   1 
ATOM   1738 C  CB  . ASN A 1 226 ? -28.55990 34.70250 -8.95234  1.000 40.06621 ? 226 ASN A CB  1 
ATOM   1739 C  CG  . ASN A 1 226 ? -27.11690 34.50305 -8.55350  1.000 31.34033 ? 226 ASN A CG  1 
ATOM   1740 O  OD1 . ASN A 1 226 ? -26.77819 34.54898 -7.37216  1.000 47.57897 ? 226 ASN A OD1 1 
ATOM   1741 N  ND2 . ASN A 1 226 ? -26.24514 34.35251 -9.54189  1.000 29.67733 ? 226 ASN A ND2 1 
ATOM   1742 N  N   . HIS A 1 227 ? -27.89094 34.28049 -12.49813 1.000 30.60757 ? 227 HIS A N   1 
ATOM   1743 C  CA  . HIS A 1 227 ? -27.81010 33.28421 -13.56140 1.000 28.68876 ? 227 HIS A CA  1 
ATOM   1744 C  C   . HIS A 1 227 ? -26.82061 32.16812 -13.21315 1.000 26.35670 ? 227 HIS A C   1 
ATOM   1745 O  O   . HIS A 1 227 ? -25.71490 32.41643 -12.71891 1.000 19.23729 ? 227 HIS A O   1 
ATOM   1746 C  CB  . HIS A 1 227 ? -27.41649 33.94997 -14.88313 1.000 23.45509 ? 227 HIS A CB  1 
ATOM   1747 C  CG  . HIS A 1 227 ? -27.21434 32.98192 -16.01324 1.000 25.83916 ? 227 HIS A CG  1 
ATOM   1748 N  ND1 . HIS A 1 227 ? -28.21748 32.14520 -16.46411 1.000 32.62736 ? 227 HIS A ND1 1 
ATOM   1749 C  CD2 . HIS A 1 227 ? -26.14226 32.73995 -16.80453 1.000 25.96117 ? 227 HIS A CD2 1 
ATOM   1750 C  CE1 . HIS A 1 227 ? -27.76401 31.41609 -17.46997 1.000 29.73498 ? 227 HIS A CE1 1 
ATOM   1751 N  NE2 . HIS A 1 227 ? -26.50783 31.75810 -17.69674 1.000 32.04335 ? 227 HIS A NE2 1 
ATOM   1752 N  N   . ILE A 1 228 ? -27.23086 30.93198 -13.47705 1.000 15.04363 ? 228 ILE A N   1 
ATOM   1753 C  CA  . ILE A 1 228 ? -26.41878 29.74290 -13.24187 1.000 17.82014 ? 228 ILE A CA  1 
ATOM   1754 C  C   . ILE A 1 228 ? -26.48035 28.89464 -14.50587 1.000 14.45559 ? 228 ILE A C   1 
ATOM   1755 O  O   . ILE A 1 228 ? -27.57104 28.64844 -15.03666 1.000 19.19960 ? 228 ILE A O   1 
ATOM   1756 C  CB  . ILE A 1 228 ? -26.92689 28.93032 -12.02933 1.000 13.21864 ? 228 ILE A CB  1 
ATOM   1757 C  CG1 . ILE A 1 228 ? -26.61709 29.65821 -10.71896 1.000 22.90676 ? 228 ILE A CG1 1 
ATOM   1758 C  CG2 . ILE A 1 228 ? -26.29651 27.53587 -12.02024 1.000 20.38370 ? 228 ILE A CG2 1 
ATOM   1759 C  CD1 . ILE A 1 228 ? -27.69681 29.49187 -9.64692  1.000 24.06501 ? 228 ILE A CD1 1 
ATOM   1760 N  N   . ASP A 1 229 ? -25.32183 28.45308 -14.99302 1.000 18.64247 ? 229 ASP A N   1 
ATOM   1761 C  CA  . ASP A 1 229 ? -25.27077 27.55577 -16.14507 1.000 20.95713 ? 229 ASP A CA  1 
ATOM   1762 C  C   . ASP A 1 229 ? -24.45894 26.32238 -15.76805 1.000 16.19953 ? 229 ASP A C   1 
ATOM   1763 O  O   . ASP A 1 229 ? -23.89484 26.24308 -14.67219 1.000 17.31654 ? 229 ASP A O   1 
ATOM   1764 C  CB  . ASP A 1 229 ? -24.69277 28.26373 -17.38433 1.000 22.55090 ? 229 ASP A CB  1 
ATOM   1765 C  CG  . ASP A 1 229 ? -23.28759 28.80194 -17.14844 1.000 28.84844 ? 229 ASP A CG  1 
ATOM   1766 O  OD1 . ASP A 1 229 ? -22.46241 28.08019 -16.54724 1.000 22.23571 ? 229 ASP A OD1 1 
ATOM   1767 O  OD2 . ASP A 1 229 ? -23.00479 29.94636 -17.55536 1.000 33.20641 ? 229 ASP A OD2 1 
ATOM   1768 N  N   . ASP A 1 230 ? -24.38775 25.34824 -16.68397 1.000 18.14547 ? 230 ASP A N   1 
ATOM   1769 C  CA  . ASP A 1 230 ? -23.63827 24.11976 -16.43521 1.000 13.96210 ? 230 ASP A CA  1 
ATOM   1770 C  C   . ASP A 1 230 ? -22.23693 24.16250 -17.03120 1.000 17.73818 ? 230 ASP A C   1 
ATOM   1771 O  O   . ASP A 1 230 ? -21.65532 23.10341 -17.32130 1.000 17.79202 ? 230 ASP A O   1 
ATOM   1772 C  CB  . ASP A 1 230 ? -24.39371 22.90141 -16.96531 1.000 18.11877 ? 230 ASP A CB  1 
ATOM   1773 C  CG  . ASP A 1 230 ? -24.43284 22.85041 -18.47711 1.000 18.22004 ? 230 ASP A CG  1 
ATOM   1774 O  OD1 . ASP A 1 230 ? -24.18048 23.89764 -19.12000 1.000 22.33462 ? 230 ASP A OD1 1 
ATOM   1775 O  OD2 . ASP A 1 230 ? -24.71070 21.75464 -19.01535 1.000 21.72910 ? 230 ASP A OD2 1 
ATOM   1776 N  N   . GLN A 1 231 ? -21.68290 25.35993 -17.21899 1.000 16.38555 ? 231 GLN A N   1 
ATOM   1777 C  CA  . GLN A 1 231 ? -20.30056 25.51057 -17.65995 1.000 18.59107 ? 231 GLN A CA  1 
ATOM   1778 C  C   . GLN A 1 231 ? -19.40913 25.64039 -16.43207 1.000 12.83773 ? 231 GLN A C   1 
ATOM   1779 O  O   . GLN A 1 231 ? -19.61197 26.52965 -15.60939 1.000 12.67306 ? 231 GLN A O   1 
ATOM   1780 C  CB  . GLN A 1 231 ? -20.15432 26.73453 -18.57088 1.000 19.25195 ? 231 GLN A CB  1 
ATOM   1781 C  CG  . GLN A 1 231 ? -21.05545 26.67631 -19.77768 1.000 19.99655 ? 231 GLN A CG  1 
ATOM   1782 C  CD  . GLN A 1 231 ? -20.75939 25.46720 -20.63022 1.000 33.62420 ? 231 GLN A CD  1 
ATOM   1783 O  OE1 . GLN A 1 231 ? -21.57915 24.55207 -20.73660 1.000 33.49816 ? 231 GLN A OE1 1 
ATOM   1784 N  NE2 . GLN A 1 231 ? -19.58697 25.45323 -21.24599 1.000 21.22005 ? 231 GLN A NE2 1 
ATOM   1785 N  N   . ALA A 1 232 ? -18.42519 24.75582 -16.30738 1.000 12.42191 ? 232 ALA A N   1 
ATOM   1786 C  CA  . ALA A 1 232 ? -17.56574 24.76244 -15.13196 1.000 13.06552 ? 232 ALA A CA  1 
ATOM   1787 C  C   . ALA A 1 232 ? -16.71414 26.02540 -15.10946 1.000 17.02428 ? 232 ALA A C   1 
ATOM   1788 O  O   . ALA A 1 232 ? -16.04695 26.35827 -16.09373 1.000 15.46556 ? 232 ALA A O   1 
ATOM   1789 C  CB  . ALA A 1 232 ? -16.67676 23.51620 -15.13236 1.000 14.17440 ? 232 ALA A CB  1 
ATOM   1790 N  N   . ASP A 1 233 ? -16.74802 26.74497 -13.99439 1.000 11.84126 ? 233 ASP A N   1 
ATOM   1791 C  CA  . ASP A 1 233 ? -15.99487 27.98916 -13.91540 1.000 14.12223 ? 233 ASP A CA  1 
ATOM   1792 C  C   . ASP A 1 233 ? -14.58038 27.77143 -13.41394 1.000 11.15790 ? 233 ASP A C   1 
ATOM   1793 O  O   . ASP A 1 233 ? -13.69380 28.56966 -13.73543 1.000 16.11885 ? 233 ASP A O   1 
ATOM   1794 C  CB  . ASP A 1 233 ? -16.75021 28.99481 -13.03775 1.000 14.55583 ? 233 ASP A CB  1 
ATOM   1795 C  CG  . ASP A 1 233 ? -18.13140 29.29862 -13.59560 1.000 23.48492 ? 233 ASP A CG  1 
ATOM   1796 O  OD1 . ASP A 1 233 ? -18.21074 30.03937 -14.60149 1.000 26.24488 ? 233 ASP A OD1 1 
ATOM   1797 O  OD2 . ASP A 1 233 ? -19.12778 28.78585 -13.04719 1.000 19.40848 ? 233 ASP A OD2 1 
ATOM   1798 N  N   . VAL A 1 234 ? -14.33848 26.67380 -12.69519 1.000 11.87520 ? 234 VAL A N   1 
ATOM   1799 C  CA  . VAL A 1 234 ? -13.00987 26.29616 -12.24033 1.000 13.79452 ? 234 VAL A CA  1 
ATOM   1800 C  C   . VAL A 1 234 ? -12.93791 24.78186 -12.33460 1.000 18.31319 ? 234 VAL A C   1 
ATOM   1801 O  O   . VAL A 1 234 ? -13.78387 24.08317 -11.77107 1.000 15.54682 ? 234 VAL A O   1 
ATOM   1802 C  CB  . VAL A 1 234 ? -12.71175 26.76530 -10.80133 1.000 11.16382 ? 234 VAL A CB  1 
ATOM   1803 C  CG1 . VAL A 1 234 ? -11.32605 26.29356 -10.38034 1.000 18.76093 ? 234 VAL A CG1 1 
ATOM   1804 C  CG2 . VAL A 1 234 ? -12.77631 28.29805 -10.72179 1.000 12.16118 ? 234 VAL A CG2 1 
ATOM   1805 N  N   . THR A 1 235 ? -11.95738 24.27671 -13.06942 1.000 13.00096 ? 235 THR A N   1 
ATOM   1806 C  CA  . THR A 1 235 ? -11.69947 22.84794 -13.18020 1.000 11.81629 ? 235 THR A CA  1 
ATOM   1807 C  C   . THR A 1 235 ? -10.27564 22.58309 -12.72279 1.000 17.96509 ? 235 THR A C   1 
ATOM   1808 O  O   . THR A 1 235 ? -9.35344  23.30767 -13.11314 1.000 14.77410 ? 235 THR A O   1 
ATOM   1809 C  CB  . THR A 1 235 ? -11.88632 22.36883 -14.61573 1.000 12.53269 ? 235 THR A CB  1 
ATOM   1810 O  OG1 . THR A 1 235 ? -13.22297 22.66693 -15.03132 1.000 13.43633 ? 235 THR A OG1 1 
ATOM   1811 C  CG2 . THR A 1 235 ? -11.62494 20.84256 -14.71503 1.000 14.04031 ? 235 THR A CG2 1 
ATOM   1812 N  N   . MET A 1 236 ? -10.09418 21.55512 -11.89762 1.000 15.92833 ? 236 MET A N   1 
ATOM   1813 C  CA  A MET A 1 236 ? -8.77540  21.20899 -11.39719 0.619 16.01168 ? 236 MET A CA  1 
ATOM   1814 C  CA  B MET A 1 236 ? -8.77207  21.20705 -11.40135 0.381 16.07879 ? 236 MET A CA  1 
ATOM   1815 C  C   . MET A 1 236 ? -8.64301  19.69948 -11.26688 1.000 17.40771 ? 236 MET A C   1 
ATOM   1816 O  O   . MET A 1 236 ? -9.59236  19.01609 -10.86781 1.000 16.96099 ? 236 MET A O   1 
ATOM   1817 C  CB  A MET A 1 236 ? -8.51132  21.91047 -10.05609 0.619 19.78641 ? 236 MET A CB  1 
ATOM   1818 C  CB  B MET A 1 236 ? -8.47849  21.85202 -10.04367 0.381 19.77392 ? 236 MET A CB  1 
ATOM   1819 C  CG  A MET A 1 236 ? -9.71426  21.95037 -9.11318  0.619 25.69827 ? 236 MET A CG  1 
ATOM   1820 C  CG  B MET A 1 236 ? -9.32104  21.30532 -8.90716  0.381 22.73394 ? 236 MET A CG  1 
ATOM   1821 S  SD  A MET A 1 236 ? -9.75199  23.41025 -8.04010  0.619 33.97937 ? 236 MET A SD  1 
ATOM   1822 S  SD  B MET A 1 236 ? -9.16242  22.27065 -7.39826  0.381 31.97579 ? 236 MET A SD  1 
ATOM   1823 C  CE  A MET A 1 236 ? -8.80838  22.84523 -6.61937  0.619 29.50074 ? 236 MET A CE  1 
ATOM   1824 C  CE  B MET A 1 236 ? -10.40249 23.53834 -7.66759  0.381 22.84781 ? 236 MET A CE  1 
ATOM   1825 N  N   . ASN A 1 237 ? -7.46399  19.19351 -11.62035 1.000 18.64799 ? 237 ASN A N   1 
ATOM   1826 C  CA  . ASN A 1 237 ? -7.08927  17.81047 -11.35478 1.000 23.21001 ? 237 ASN A CA  1 
ATOM   1827 C  C   . ASN A 1 237 ? -6.58165  17.67511 -9.91826  1.000 21.45650 ? 237 ASN A C   1 
ATOM   1828 O  O   . ASN A 1 237 ? -5.80117  18.50531 -9.44860  1.000 23.41576 ? 237 ASN A O   1 
ATOM   1829 C  CB  . ASN A 1 237 ? -5.99683  17.35692 -12.32772 1.000 23.20590 ? 237 ASN A CB  1 
ATOM   1830 C  CG  . ASN A 1 237 ? -6.46815  17.31179 -13.77104 1.000 37.09517 ? 237 ASN A CG  1 
ATOM   1831 O  OD1 . ASN A 1 237 ? -7.66019  17.19632 -14.04090 1.000 28.29015 ? 237 ASN A OD1 1 
ATOM   1832 N  ND2 . ASN A 1 237 ? -5.52779  17.39752 -14.70566 1.000 36.26536 ? 237 ASN A ND2 1 
ATOM   1833 N  N   . GLY A 1 238 ? -7.01183  16.61285 -9.22915  1.000 20.89540 ? 238 GLY A N   1 
ATOM   1834 C  CA  . GLY A 1 238 ? -6.53417  16.29441 -7.89952  1.000 17.03631 ? 238 GLY A CA  1 
ATOM   1835 C  C   . GLY A 1 238 ? -5.95364  14.89148 -7.89588  1.000 22.21254 ? 238 GLY A C   1 
ATOM   1836 O  O   . GLY A 1 238 ? -6.16335  14.09628 -8.82323  1.000 17.37413 ? 238 GLY A O   1 
ATOM   1837 N  N   . SER A 1 239 ? -5.21340  14.58184 -6.82918  1.000 19.09240 ? 239 SER A N   1 
ATOM   1838 C  CA  A SER A 1 239 ? -4.58397  13.27462 -6.70576  0.534 31.92846 ? 239 SER A CA  1 
ATOM   1839 C  CA  B SER A 1 239 ? -4.56882  13.28215 -6.70313  0.466 31.89667 ? 239 SER A CA  1 
ATOM   1840 C  C   . SER A 1 239 ? -4.63623  12.81283 -5.25921  1.000 30.75467 ? 239 SER A C   1 
ATOM   1841 O  O   . SER A 1 239 ? -4.26936  13.56126 -4.35069  1.000 26.43117 ? 239 SER A O   1 
ATOM   1842 C  CB  A SER A 1 239 ? -3.12635  13.29442 -7.19031  0.534 31.99901 ? 239 SER A CB  1 
ATOM   1843 C  CB  B SER A 1 239 ? -3.10499  13.34102 -7.16389  0.466 31.95305 ? 239 SER A CB  1 
ATOM   1844 O  OG  A SER A 1 239 ? -2.43174  12.14100 -6.73840  0.534 32.84016 ? 239 SER A OG  1 
ATOM   1845 O  OG  B SER A 1 239 ? -3.01860  13.64432 -8.54425  0.466 26.62798 ? 239 SER A OG  1 
ATOM   1846 N  N   . VAL A 1 240 ? -5.09376  11.58239 -5.05383  1.000 28.72001 ? 240 VAL A N   1 
ATOM   1847 C  CA  . VAL A 1 240 ? -5.09296  10.95350 -3.73654  1.000 30.64174 ? 240 VAL A CA  1 
ATOM   1848 C  C   . VAL A 1 240 ? -3.75976  10.22665 -3.56805  1.000 26.88998 ? 240 VAL A C   1 
ATOM   1849 O  O   . VAL A 1 240 ? -3.44479  9.34623  -4.38104  1.000 26.71939 ? 240 VAL A O   1 
ATOM   1850 C  CB  . VAL A 1 240 ? -6.27145  9.98478  -3.56569  1.000 32.42085 ? 240 VAL A CB  1 
ATOM   1851 C  CG1 . VAL A 1 240 ? -6.14031  9.22682  -2.25545  1.000 28.19668 ? 240 VAL A CG1 1 
ATOM   1852 C  CG2 . VAL A 1 240 ? -7.60743  10.73264 -3.61173  1.000 23.20897 ? 240 VAL A CG2 1 
ATOM   1853 N  N   . PRO A 1 241 ? -2.95980  10.55422 -2.54775  1.000 38.16156 ? 241 PRO A N   1 
ATOM   1854 C  CA  . PRO A 1 241 ? -1.69662  9.82866  -2.33157  1.000 32.88491 ? 241 PRO A CA  1 
ATOM   1855 C  C   . PRO A 1 241 ? -1.88927  8.32139  -2.25574  1.000 41.29007 ? 241 PRO A C   1 
ATOM   1856 O  O   . PRO A 1 241 ? -2.63124  7.82541  -1.40341  1.000 45.80183 ? 241 PRO A O   1 
ATOM   1857 C  CB  . PRO A 1 241 ? -1.19626  10.40289 -1.00110  1.000 45.02528 ? 241 PRO A CB  1 
ATOM   1858 C  CG  . PRO A 1 241 ? -1.77416  11.78520 -0.96447  1.000 35.44405 ? 241 PRO A CG  1 
ATOM   1859 C  CD  . PRO A 1 241 ? -3.15642  11.62494 -1.55603  1.000 38.30759 ? 241 PRO A CD  1 
ATOM   1860 N  N   A ASN A 1 242 ? -1.21937  7.58601  -3.14332  0.502 35.50596 ? 242 ASN A N   1 
ATOM   1861 N  N   B ASN A 1 242 ? -1.22380  7.58667  -3.14618  0.498 35.50255 ? 242 ASN A N   1 
ATOM   1862 C  CA  A ASN A 1 242 ? -1.35307  6.13680  -3.24769  0.502 36.00009 ? 242 ASN A CA  1 
ATOM   1863 C  CA  B ASN A 1 242 ? -1.34385  6.13791  -3.27345  0.498 35.98186 ? 242 ASN A CA  1 
ATOM   1864 C  C   A ASN A 1 242 ? -2.78744  5.70902  -3.54052  0.502 38.11476 ? 242 ASN A C   1 
ATOM   1865 C  C   B ASN A 1 242 ? -2.75845  5.69800  -3.62487  0.498 38.12519 ? 242 ASN A C   1 
ATOM   1866 O  O   A ASN A 1 242 ? -3.15127  4.54936  -3.31930  0.502 37.91852 ? 242 ASN A O   1 
ATOM   1867 O  O   B ASN A 1 242 ? -3.07913  4.50759  -3.51991  0.498 37.71043 ? 242 ASN A O   1 
ATOM   1868 C  CB  A ASN A 1 242 ? -0.83192  5.43382  -1.98657  0.502 40.90373 ? 242 ASN A CB  1 
ATOM   1869 C  CB  B ASN A 1 242 ? -0.87443  5.41924  -2.00117  0.498 40.91276 ? 242 ASN A CB  1 
ATOM   1870 C  CG  A ASN A 1 242 ? 0.39129   6.11593  -1.39832  0.502 34.58543 ? 242 ASN A CG  1 
ATOM   1871 C  CG  B ASN A 1 242 ? 0.01932   4.23023  -2.29913  0.498 36.74905 ? 242 ASN A CG  1 
ATOM   1872 O  OD1 A ASN A 1 242 ? 1.44502   6.16697  -2.03116  0.502 40.16363 ? 242 ASN A OD1 1 
ATOM   1873 O  OD1 B ASN A 1 242 ? 1.20372   4.38763  -2.59176  0.498 35.99834 ? 242 ASN A OD1 1 
ATOM   1874 N  ND2 A ASN A 1 242 ? 0.26267   6.62869  -0.17895  0.502 35.15121 ? 242 ASN A ND2 1 
ATOM   1875 N  ND2 B ASN A 1 242 ? -0.54628  3.03064  -2.22254  0.498 36.47371 ? 242 ASN A ND2 1 
ATOM   1876 N  N   . GLY A 1 243 ? -3.61143  6.62673  -4.04444  1.000 43.33704 ? 243 GLY A N   1 
ATOM   1877 C  CA  . GLY A 1 243 ? -4.97507  6.33842  -4.42315  1.000 27.38997 ? 243 GLY A CA  1 
ATOM   1878 C  C   . GLY A 1 243 ? -5.26862  6.84659  -5.82320  1.000 31.81330 ? 243 GLY A C   1 
ATOM   1879 O  O   . GLY A 1 243 ? -4.37835  6.95763  -6.67391  1.000 28.64195 ? 243 GLY A O   1 
ATOM   1880 N  N   . ARG A 1 244 ? -6.54132  7.16713  -6.04809  1.000 24.04338 ? 244 ARG A N   1 
ATOM   1881 C  CA  . ARG A 1 244 ? -7.02329  7.53260  -7.37072  1.000 18.08430 ? 244 ARG A CA  1 
ATOM   1882 C  C   . ARG A 1 244 ? -6.79487  9.01503  -7.66115  1.000 15.96781 ? 244 ARG A C   1 
ATOM   1883 O  O   . ARG A 1 244 ? -6.62814  9.84182  -6.76177  1.000 19.39557 ? 244 ARG A O   1 
ATOM   1884 C  CB  . ARG A 1 244 ? -8.51869  7.20013  -7.50531  1.000 16.57485 ? 244 ARG A CB  1 
ATOM   1885 C  CG  . ARG A 1 244 ? -8.79026  5.71570  -7.38349  1.000 17.43232 ? 244 ARG A CG  1 
ATOM   1886 C  CD  . ARG A 1 244 ? -10.22535 5.35668  -7.68557  1.000 16.92951 ? 244 ARG A CD  1 
ATOM   1887 N  NE  . ARG A 1 244 ? -10.39228 3.90696  -7.67580  1.000 22.61865 ? 244 ARG A NE  1 
ATOM   1888 C  CZ  . ARG A 1 244 ? -10.01507 3.09956  -8.66094  1.000 30.95885 ? 244 ARG A CZ  1 
ATOM   1889 N  NH1 . ARG A 1 244 ? -9.47166  3.56982  -9.77195  1.000 26.59784 ? 244 ARG A NH1 1 
ATOM   1890 N  NH2 . ARG A 1 244 ? -10.19076 1.78645  -8.52941  1.000 21.42396 ? 244 ARG A NH2 1 
ATOM   1891 N  N   . THR A 1 245 ? -6.78630  9.34265  -8.94735  1.000 17.44732 ? 245 THR A N   1 
ATOM   1892 C  CA  . THR A 1 245 ? -6.86565  10.72493 -9.38815  1.000 18.83803 ? 245 THR A CA  1 
ATOM   1893 C  C   . THR A 1 245 ? -8.32626  11.09616 -9.60657  1.000 15.64969 ? 245 THR A C   1 
ATOM   1894 O  O   . THR A 1 245 ? -9.20536  10.23178 -9.67029  1.000 17.33962 ? 245 THR A O   1 
ATOM   1895 C  CB  . THR A 1 245 ? -6.07061  10.93965 -10.67971 1.000 20.19001 ? 245 THR A CB  1 
ATOM   1896 O  OG1 . THR A 1 245 ? -6.60126  10.10385 -11.71576 1.000 20.39272 ? 245 THR A OG1 1 
ATOM   1897 C  CG2 . THR A 1 245 ? -4.60872  10.57484 -10.45636 1.000 23.74239 ? 245 THR A CG2 1 
ATOM   1898 N  N   . TYR A 1 246 ? -8.58253  12.39814 -9.70174  1.000 13.85006 ? 246 TYR A N   1 
ATOM   1899 C  CA  . TYR A 1 246 ? -9.94515  12.86410 -9.90026  1.000 16.29140 ? 246 TYR A CA  1 
ATOM   1900 C  C   . TYR A 1 246 ? -9.89589  14.26933 -10.48112 1.000 15.93895 ? 246 TYR A C   1 
ATOM   1901 O  O   . TYR A 1 246 ? -8.87242  14.95683 -10.41123 1.000 17.68570 ? 246 TYR A O   1 
ATOM   1902 C  CB  . TYR A 1 246 ? -10.74423 12.84362 -8.59037  1.000 15.26721 ? 246 TYR A CB  1 
ATOM   1903 C  CG  . TYR A 1 246 ? -10.16733 13.71064 -7.48278  1.000 13.06784 ? 246 TYR A CG  1 
ATOM   1904 C  CD1 . TYR A 1 246 ? -9.23110  13.19478 -6.58485  1.000 20.80093 ? 246 TYR A CD1 1 
ATOM   1905 C  CD2 . TYR A 1 246 ? -10.54165 15.03906 -7.34516  1.000 12.47051 ? 246 TYR A CD2 1 
ATOM   1906 C  CE1 . TYR A 1 246 ? -8.69259  13.98265 -5.57720  1.000 20.23237 ? 246 TYR A CE1 1 
ATOM   1907 C  CE2 . TYR A 1 246 ? -10.02146 15.83384 -6.32779  1.000 17.83529 ? 246 TYR A CE2 1 
ATOM   1908 C  CZ  . TYR A 1 246 ? -9.09312  15.29816 -5.45289  1.000 23.01485 ? 246 TYR A CZ  1 
ATOM   1909 O  OH  . TYR A 1 246 ? -8.56680  16.08170 -4.44643  1.000 25.49474 ? 246 TYR A OH  1 
ATOM   1910 N  N   . THR A 1 247 ? -11.00796 14.67703 -11.07642 1.000 12.96748 ? 247 THR A N   1 
ATOM   1911 C  CA  . THR A 1 247 ? -11.16671 16.01790 -11.60344 1.000 12.57508 ? 247 THR A CA  1 
ATOM   1912 C  C   . THR A 1 247 ? -12.30706 16.68523 -10.86243 1.000 15.12893 ? 247 THR A C   1 
ATOM   1913 O  O   . THR A 1 247 ? -13.36825 16.08018 -10.68292 1.000 13.89882 ? 247 THR A O   1 
ATOM   1914 C  CB  . THR A 1 247 ? -11.45879 16.00549 -13.10643 1.000 15.66327 ? 247 THR A CB  1 
ATOM   1915 O  OG1 . THR A 1 247 ? -10.48756 15.17513 -13.76277 1.000 16.51878 ? 247 THR A OG1 1 
ATOM   1916 C  CG2 . THR A 1 247 ? -11.38152 17.43903 -13.66188 1.000 14.05926 ? 247 THR A CG2 1 
ATOM   1917 N  N   . ARG A 1 248 ? -12.08339 17.91425 -10.41233 1.000 13.69683 ? 248 ARG A N   1 
ATOM   1918 C  CA  . ARG A 1 248 ? -13.11312 18.67034 -9.71844  1.000 11.48616 ? 248 ARG A CA  1 
ATOM   1919 C  C   . ARG A 1 248 ? -13.59784 19.77187 -10.64372 1.000 14.09423 ? 248 ARG A C   1 
ATOM   1920 O  O   . ARG A 1 248 ? -12.78467 20.47567 -11.25428 1.000 14.25078 ? 248 ARG A O   1 
ATOM   1921 C  CB  . ARG A 1 248 ? -12.60622 19.28549 -8.40636  1.000 14.64399 ? 248 ARG A CB  1 
ATOM   1922 C  CG  . ARG A 1 248 ? -13.40598 20.58032 -8.07073  1.000 17.58660 ? 248 ARG A CG  1 
ATOM   1923 C  CD  . ARG A 1 248 ? -13.04155 21.24193 -6.73827  1.000 26.37784 ? 248 ARG A CD  1 
ATOM   1924 N  NE  . ARG A 1 248 ? -13.11040 20.34379 -5.59100  1.000 20.41159 ? 248 ARG A NE  1 
ATOM   1925 C  CZ  . ARG A 1 248 ? -12.05598 19.76998 -5.02709  1.000 33.58598 ? 248 ARG A CZ  1 
ATOM   1926 N  NH1 . ARG A 1 248 ? -10.83135 19.96072 -5.49562  1.000 29.30045 ? 248 ARG A NH1 1 
ATOM   1927 N  NH2 . ARG A 1 248 ? -12.23338 18.98454 -3.96802  1.000 27.69074 ? 248 ARG A NH2 1 
ATOM   1928 N  N   . TYR A 1 249 ? -14.91657 19.89949 -10.76724 1.000 13.14405 ? 249 TYR A N   1 
ATOM   1929 C  CA  . TYR A 1 249 ? -15.54298 20.97044 -11.52722 1.000 12.02631 ? 249 TYR A CA  1 
ATOM   1930 C  C   . TYR A 1 249 ? -16.33912 21.83993 -10.57096 1.000 13.36334 ? 249 TYR A C   1 
ATOM   1931 O  O   . TYR A 1 249 ? -17.10843 21.31879 -9.76598  1.000 12.66789 ? 249 TYR A O   1 
ATOM   1932 C  CB  . TYR A 1 249 ? -16.47172 20.42565 -12.61735 1.000 12.30824 ? 249 TYR A CB  1 
ATOM   1933 C  CG  . TYR A 1 249 ? -15.78448 19.46886 -13.55175 1.000 13.73975 ? 249 TYR A CG  1 
ATOM   1934 C  CD1 . TYR A 1 249 ? -15.57630 18.14557 -13.18854 1.000 12.13103 ? 249 TYR A CD1 1 
ATOM   1935 C  CD2 . TYR A 1 249 ? -15.35204 19.88739 -14.80462 1.000 12.37705 ? 249 TYR A CD2 1 
ATOM   1936 C  CE1 . TYR A 1 249 ? -14.95787 17.25175 -14.06500 1.000 15.36107 ? 249 TYR A CE1 1 
ATOM   1937 C  CE2 . TYR A 1 249 ? -14.73634 19.00961 -15.67686 1.000 17.33083 ? 249 TYR A CE2 1 
ATOM   1938 C  CZ  . TYR A 1 249 ? -14.53107 17.69934 -15.29594 1.000 18.60817 ? 249 TYR A CZ  1 
ATOM   1939 O  OH  . TYR A 1 249 ? -13.90468 16.83500 -16.16317 1.000 19.11537 ? 249 TYR A OH  1 
ATOM   1940 N  N   . LEU A 1 250 ? -16.14486 23.15290 -10.65062 1.000 10.04635 ? 250 LEU A N   1 
ATOM   1941 C  CA  . LEU A 1 250 ? -16.85100 24.10328 -9.79855  1.000 14.22146 ? 250 LEU A CA  1 
ATOM   1942 C  C   . LEU A 1 250 ? -17.72087 24.99406 -10.67084 1.000 16.46297 ? 250 LEU A C   1 
ATOM   1943 O  O   . LEU A 1 250 ? -17.24407 25.54764 -11.66934 1.000 16.93881 ? 250 LEU A O   1 
ATOM   1944 C  CB  . LEU A 1 250 ? -15.86384 24.95472 -8.97711  1.000 15.78404 ? 250 LEU A CB  1 
ATOM   1945 C  CG  . LEU A 1 250 ? -15.16130 24.14073 -7.88796  1.000 15.95598 ? 250 LEU A CG  1 
ATOM   1946 C  CD1 . LEU A 1 250 ? -13.91087 24.86533 -7.36862  1.000 16.07979 ? 250 LEU A CD1 1 
ATOM   1947 C  CD2 . LEU A 1 250 ? -16.14287 23.83126 -6.77147  1.000 18.93582 ? 250 LEU A CD2 1 
ATOM   1948 N  N   . TYR A 1 251 ? -18.99333 25.12576 -10.28780 1.000 10.80209 ? 251 TYR A N   1 
ATOM   1949 C  CA  . TYR A 1 251 ? -19.99291 25.88932 -11.02445 1.000 14.49564 ? 251 TYR A CA  1 
ATOM   1950 C  C   . TYR A 1 251 ? -20.43126 27.04416 -10.13308 1.000 18.52800 ? 251 TYR A C   1 
ATOM   1951 O  O   . TYR A 1 251 ? -21.02415 26.82531 -9.06646  1.000 14.11344 ? 251 TYR A O   1 
ATOM   1952 C  CB  . TYR A 1 251 ? -21.17490 24.99228 -11.41136 1.000 13.32487 ? 251 TYR A CB  1 
ATOM   1953 C  CG  . TYR A 1 251 ? -20.72469 23.76205 -12.18007 1.000 13.95130 ? 251 TYR A CG  1 
ATOM   1954 C  CD1 . TYR A 1 251 ? -20.23835 22.63660 -11.51208 1.000 14.39502 ? 251 TYR A CD1 1 
ATOM   1955 C  CD2 . TYR A 1 251 ? -20.77053 23.73061 -13.56541 1.000 16.35792 ? 251 TYR A CD2 1 
ATOM   1956 C  CE1 . TYR A 1 251 ? -19.81895 21.51394 -12.20484 1.000 15.38456 ? 251 TYR A CE1 1 
ATOM   1957 C  CE2 . TYR A 1 251 ? -20.34035 22.62519 -14.27019 1.000 9.81839  ? 251 TYR A CE2 1 
ATOM   1958 C  CZ  . TYR A 1 251 ? -19.86736 21.51724 -13.58875 1.000 15.06815 ? 251 TYR A CZ  1 
ATOM   1959 O  OH  . TYR A 1 251 ? -19.43722 20.40528 -14.28150 1.000 12.79040 ? 251 TYR A OH  1 
ATOM   1960 N  N   . LYS A 1 252 ? -20.13351 28.26760 -10.56070 1.000 16.69870 ? 252 LYS A N   1 
ATOM   1961 C  CA  . LYS A 1 252 ? -20.50810 29.47339 -9.83651  1.000 15.37072 ? 252 LYS A CA  1 
ATOM   1962 C  C   . LYS A 1 252 ? -21.77143 30.07322 -10.43690 1.000 18.41617 ? 252 LYS A C   1 
ATOM   1963 O  O   . LYS A 1 252 ? -22.08656 29.89131 -11.61447 1.000 23.72792 ? 252 LYS A O   1 
ATOM   1964 C  CB  . LYS A 1 252 ? -19.39540 30.51823 -9.91087  1.000 12.38726 ? 252 LYS A CB  1 
ATOM   1965 C  CG  . LYS A 1 252 ? -18.03799 30.03141 -9.51913  1.000 17.63239 ? 252 LYS A CG  1 
ATOM   1966 C  CD  . LYS A 1 252 ? -17.34284 31.09207 -8.70363  1.000 31.84004 ? 252 LYS A CD  1 
ATOM   1967 C  CE  . LYS A 1 252 ? -15.90889 31.24989 -9.15702  1.000 40.85073 ? 252 LYS A CE  1 
ATOM   1968 N  NZ  . LYS A 1 252 ? -15.49968 32.69488 -9.19037  1.000 33.28555 ? 252 LYS A NZ  1 
ATOM   1969 N  N   . ASP A 1 253 ? -22.47891 30.82959 -9.61424  1.000 16.58133 ? 253 ASP A N   1 
ATOM   1970 C  CA  . ASP A 1 253 ? -23.53576 31.67742 -10.13223 1.000 21.45560 ? 253 ASP A CA  1 
ATOM   1971 C  C   . ASP A 1 253 ? -22.93440 33.04325 -10.46232 1.000 35.16852 ? 253 ASP A C   1 
ATOM   1972 O  O   . ASP A 1 253 ? -21.73596 33.27885 -10.26209 1.000 22.13324 ? 253 ASP A O   1 
ATOM   1973 C  CB  . ASP A 1 253 ? -24.69240 31.73937 -9.13507  1.000 14.75883 ? 253 ASP A CB  1 
ATOM   1974 C  CG  . ASP A 1 253 ? -24.34601 32.48801 -7.86048  1.000 28.49358 ? 253 ASP A CG  1 
ATOM   1975 O  OD1 . ASP A 1 253 ? -23.23708 33.06144 -7.75776  1.000 25.87404 ? 253 ASP A OD1 1 
ATOM   1976 O  OD2 . ASP A 1 253 ? -25.19847 32.48224 -6.94773  1.000 25.83487 ? 253 ASP A OD2 1 
ATOM   1977 N  N   . GLN A 1 254 ? -23.75651 33.95216 -11.00293 1.000 23.93175 ? 254 GLN A N   1 
ATOM   1978 C  CA  . GLN A 1 254 ? -23.21881 35.25776 -11.37544 1.000 34.17361 ? 254 GLN A CA  1 
ATOM   1979 C  C   . GLN A 1 254 ? -22.78601 36.06101 -10.14906 1.000 20.60445 ? 254 GLN A C   1 
ATOM   1980 O  O   . GLN A 1 254 ? -21.86296 36.87631 -10.24618 1.000 34.43434 ? 254 GLN A O   1 
ATOM   1981 C  CB  . GLN A 1 254 ? -24.23670 36.04535 -12.21204 1.000 33.99230 ? 254 GLN A CB  1 
ATOM   1982 C  CG  . GLN A 1 254 ? -25.43626 36.56607 -11.43325 1.000 42.77265 ? 254 GLN A CG  1 
ATOM   1983 C  CD  . GLN A 1 254 ? -26.45262 37.28669 -12.31628 1.000 46.68144 ? 254 GLN A CD  1 
ATOM   1984 O  OE1 . GLN A 1 254 ? -27.30702 36.66045 -12.93853 1.000 43.04517 ? 254 GLN A OE1 1 
ATOM   1985 N  NE2 . GLN A 1 254 ? -26.37452 38.61259 -12.34824 1.000 40.46914 ? 254 GLN A NE2 1 
ATOM   1986 N  N   . ASN A 1 255 ? -23.41664 35.84055 -8.99165  1.000 26.77258 ? 255 ASN A N   1 
ATOM   1987 C  CA  . ASN A 1 255 ? -22.99281 36.52934 -7.77162  1.000 36.63610 ? 255 ASN A CA  1 
ATOM   1988 C  C   . ASN A 1 255 ? -21.62618 36.08895 -7.26373  1.000 34.63537 ? 255 ASN A C   1 
ATOM   1989 O  O   . ASN A 1 255 ? -21.11587 36.70476 -6.32221  1.000 33.43226 ? 255 ASN A O   1 
ATOM   1990 C  CB  . ASN A 1 255 ? -24.01344 36.33947 -6.64321  1.000 31.54538 ? 255 ASN A CB  1 
ATOM   1991 C  CG  . ASN A 1 255 ? -25.33723 37.03094 -6.91763  1.000 42.71782 ? 255 ASN A CG  1 
ATOM   1992 O  OD1 . ASN A 1 255 ? -25.46376 37.80222 -7.87334  1.000 39.31415 ? 255 ASN A OD1 1 
ATOM   1993 N  ND2 . ASN A 1 255 ? -26.33471 36.75654 -6.07471  1.000 40.99065 ? 255 ASN A ND2 1 
ATOM   1994 N  N   . GLY A 1 256 ? -21.02931 35.04815 -7.84198  1.000 30.42298 ? 256 GLY A N   1 
ATOM   1995 C  CA  . GLY A 1 256 ? -19.74760 34.55330 -7.38145  1.000 26.72357 ? 256 GLY A CA  1 
ATOM   1996 C  C   . GLY A 1 256 ? -19.80232 33.41307 -6.37927  1.000 32.63173 ? 256 GLY A C   1 
ATOM   1997 O  O   . GLY A 1 256 ? -18.74561 33.00621 -5.87773  1.000 26.91571 ? 256 GLY A O   1 
ATOM   1998 N  N   . ASN A 1 257 ? -20.99095 32.89486 -6.06215  1.000 18.80532 ? 257 ASN A N   1 
ATOM   1999 C  CA  . ASN A 1 257 ? -21.12714 31.75690 -5.15810  1.000 25.36815 ? 257 ASN A CA  1 
ATOM   2000 C  C   . ASN A 1 257 ? -20.87731 30.45246 -5.90515  1.000 16.21438 ? 257 ASN A C   1 
ATOM   2001 O  O   . ASN A 1 257 ? -21.27627 30.30243 -7.06370  1.000 16.96836 ? 257 ASN A O   1 
ATOM   2002 C  CB  . ASN A 1 257 ? -22.53031 31.70484 -4.54937  1.000 25.47544 ? 257 ASN A CB  1 
ATOM   2003 C  CG  . ASN A 1 257 ? -22.97391 33.02905 -3.96488  1.000 44.38683 ? 257 ASN A CG  1 
ATOM   2004 O  OD1 . ASN A 1 257 ? -22.49088 33.44985 -2.91000  1.000 48.89821 ? 257 ASN A OD1 1 
ATOM   2005 N  ND2 . ASN A 1 257 ? -23.92646 33.68355 -4.63553  1.000 39.60942 ? 257 ASN A ND2 1 
ATOM   2006 N  N   . VAL A 1 258 ? -20.21952 29.50635 -5.23869  1.000 14.24663 ? 258 VAL A N   1 
ATOM   2007 C  CA  . VAL A 1 258 ? -20.22237 28.13928 -5.74100  1.000 8.25329  ? 258 VAL A CA  1 
ATOM   2008 C  C   . VAL A 1 258 ? -21.60000 27.55155 -5.49438  1.000 16.00102 ? 258 VAL A C   1 
ATOM   2009 O  O   . VAL A 1 258 ? -22.05052 27.46802 -4.34754  1.000 15.27672 ? 258 VAL A O   1 
ATOM   2010 C  CB  . VAL A 1 258 ? -19.13634 27.29466 -5.07108  1.000 18.14566 ? 258 VAL A CB  1 
ATOM   2011 C  CG1 . VAL A 1 258 ? -19.18360 25.83405 -5.58829  1.000 18.54074 ? 258 VAL A CG1 1 
ATOM   2012 C  CG2 . VAL A 1 258 ? -17.78413 27.90735 -5.33472  1.000 15.10157 ? 258 VAL A CG2 1 
ATOM   2013 N  N   . VAL A 1 259 ? -22.28942 27.17629 -6.57024  1.000 12.45499 ? 259 VAL A N   1 
ATOM   2014 C  CA  . VAL A 1 259 ? -23.63110 26.60669 -6.43791  1.000 13.26455 ? 259 VAL A CA  1 
ATOM   2015 C  C   . VAL A 1 259 ? -23.59348 25.10155 -6.66566  1.000 13.48090 ? 259 VAL A C   1 
ATOM   2016 O  O   . VAL A 1 259 ? -24.43007 24.36179 -6.12916  1.000 12.49228 ? 259 VAL A O   1 
ATOM   2017 C  CB  . VAL A 1 259 ? -24.64210 27.26885 -7.39208  1.000 17.95575 ? 259 VAL A CB  1 
ATOM   2018 C  CG1 . VAL A 1 259 ? -24.85781 28.72370 -7.00735  1.000 22.19759 ? 259 VAL A CG1 1 
ATOM   2019 C  CG2 . VAL A 1 259 ? -24.15339 27.15857 -8.82152  1.000 23.65960 ? 259 VAL A CG2 1 
ATOM   2020 N  N   . MET A 1 260 ? -22.64164 24.62682 -7.46924  1.000 13.03819 ? 260 MET A N   1 
ATOM   2021 C  CA  . MET A 1 260 ? -22.56478 23.19073 -7.72370  1.000 16.99159 ? 260 MET A CA  1 
ATOM   2022 C  C   . MET A 1 260 ? -21.11024 22.76129 -7.85060  1.000 9.99826  ? 260 MET A C   1 
ATOM   2023 O  O   . MET A 1 260 ? -20.22507 23.56291 -8.16101  1.000 12.11951 ? 260 MET A O   1 
ATOM   2024 C  CB  . MET A 1 260 ? -23.32882 22.81109 -8.98721  1.000 10.94264 ? 260 MET A CB  1 
ATOM   2025 C  CG  . MET A 1 260 ? -24.81643 23.09650 -8.87591  1.000 19.40851 ? 260 MET A CG  1 
ATOM   2026 S  SD  . MET A 1 260 ? -25.65997 22.71858 -10.39559 1.000 26.01495 ? 260 MET A SD  1 
ATOM   2027 C  CE  . MET A 1 260 ? -24.77107 23.75865 -11.58631 1.000 16.06965 ? 260 MET A CE  1 
ATOM   2028 N  N   . GLU A 1 261 ? -20.87020 21.47631 -7.59983  1.000 10.52404 ? 261 GLU A N   1 
ATOM   2029 C  CA  . GLU A 1 261 ? -19.52882 20.91713 -7.64653  1.000 11.98401 ? 261 GLU A CA  1 
ATOM   2030 C  C   . GLU A 1 261 ? -19.63760 19.49248 -8.16080  1.000 10.19237 ? 261 GLU A C   1 
ATOM   2031 O  O   . GLU A 1 261 ? -20.57952 18.78745 -7.81213  1.000 13.34185 ? 261 GLU A O   1 
ATOM   2032 C  CB  . GLU A 1 261 ? -18.88467 20.93380 -6.26240  1.000 10.75617 ? 261 GLU A CB  1 
ATOM   2033 C  CG  . GLU A 1 261 ? -17.47249 20.38005 -6.20321  1.000 11.32054 ? 261 GLU A CG  1 
ATOM   2034 C  CD  . GLU A 1 261 ? -16.80652 20.72658 -4.88953  1.000 17.14058 ? 261 GLU A CD  1 
ATOM   2035 O  OE1 . GLU A 1 261 ? -17.43439 21.45944 -4.09806  1.000 14.86040 ? 261 GLU A OE1 1 
ATOM   2036 O  OE2 . GLU A 1 261 ? -15.66471 20.27999 -4.64841  1.000 16.94676 ? 261 GLU A OE2 1 
ATOM   2037 N  N   . LYS A 1 262 ? -18.68831 19.07512 -8.99614  1.000 8.14764  ? 262 LYS A N   1 
ATOM   2038 C  CA  . LYS A 1 262 ? -18.71569 17.73280 -9.55643  1.000 10.69423 ? 262 LYS A CA  1 
ATOM   2039 C  C   . LYS A 1 262 ? -17.34212 17.10652 -9.39327  1.000 11.80716 ? 262 LYS A C   1 
ATOM   2040 O  O   . LYS A 1 262 ? -16.34064 17.68114 -9.82798  1.000 13.80995 ? 262 LYS A O   1 
ATOM   2041 C  CB  . LYS A 1 262 ? -19.13928 17.73966 -11.02981 1.000 13.16022 ? 262 LYS A CB  1 
ATOM   2042 C  CG  . LYS A 1 262 ? -19.08884 16.35305 -11.68388 1.000 10.59905 ? 262 LYS A CG  1 
ATOM   2043 C  CD  . LYS A 1 262 ? -19.80253 16.34501 -13.05118 1.000 16.41228 ? 262 LYS A CD  1 
ATOM   2044 C  CE  . LYS A 1 262 ? -19.03373 17.13357 -14.07593 1.000 22.51825 ? 262 LYS A CE  1 
ATOM   2045 N  NZ  . LYS A 1 262 ? -19.79488 17.30886 -15.34308 1.000 17.40123 ? 262 LYS A NZ  1 
ATOM   2046 N  N   . ILE A 1 263 ? -17.29299 15.95092 -8.73616  1.000 10.66881 ? 263 ILE A N   1 
ATOM   2047 C  CA  . ILE A 1 263 ? -16.05704 15.21509 -8.52021  1.000 11.04352 ? 263 ILE A CA  1 
ATOM   2048 C  C   . ILE A 1 263 ? -16.15239 13.91654 -9.31504  1.000 10.18479 ? 263 ILE A C   1 
ATOM   2049 O  O   . ILE A 1 263 ? -16.89789 13.00020 -8.95036  1.000 13.33642 ? 263 ILE A O   1 
ATOM   2050 C  CB  . ILE A 1 263 ? -15.80840 14.94754 -7.02983  1.000 9.02236  ? 263 ILE A CB  1 
ATOM   2051 C  CG1 . ILE A 1 263 ? -15.88851 16.24171 -6.21437  1.000 13.48783 ? 263 ILE A CG1 1 
ATOM   2052 C  CG2 . ILE A 1 263 ? -14.46837 14.24504 -6.83340  1.000 14.07181 ? 263 ILE A CG2 1 
ATOM   2053 C  CD1 . ILE A 1 263 ? -14.81845 17.28598 -6.54461  1.000 17.07151 ? 263 ILE A CD1 1 
ATOM   2054 N  N   . MET A 1 264 ? -15.39196 13.82792 -10.39841 1.000 12.56136 ? 264 MET A N   1 
ATOM   2055 C  CA  . MET A 1 264 ? -15.25518 12.60832 -11.19315 1.000 13.49941 ? 264 MET A CA  1 
ATOM   2056 C  C   . MET A 1 264 ? -13.97838 11.88813 -10.79471 1.000 11.94594 ? 264 MET A C   1 
ATOM   2057 O  O   . MET A 1 264 ? -12.87515 12.40665 -11.00290 1.000 16.31642 ? 264 MET A O   1 
ATOM   2058 C  CB  . MET A 1 264 ? -15.26428 12.91779 -12.68885 1.000 14.02875 ? 264 MET A CB  1 
ATOM   2059 C  CG  . MET A 1 264 ? -16.37084 13.83746 -13.19953 1.000 15.50326 ? 264 MET A CG  1 
ATOM   2060 S  SD  . MET A 1 264 ? -17.97902 13.02176 -12.94343 1.000 15.53511 ? 264 MET A SD  1 
ATOM   2061 C  CE  . MET A 1 264 ? -17.75818 11.48911 -13.75541 1.000 12.36567 ? 264 MET A CE  1 
ATOM   2062 N  N   . VAL A 1 265 ? -14.12376 10.70079 -10.21846 1.000 11.84363 ? 265 VAL A N   1 
ATOM   2063 C  CA  . VAL A 1 265 ? -12.98515 9.92812  -9.72960  1.000 11.12084 ? 265 VAL A CA  1 
ATOM   2064 C  C   . VAL A 1 265 ? -12.57981 8.94816  -10.82427 1.000 14.58836 ? 265 VAL A C   1 
ATOM   2065 O  O   . VAL A 1 265 ? -13.37844 8.10634  -11.25379 1.000 12.02516 ? 265 VAL A O   1 
ATOM   2066 C  CB  . VAL A 1 265 ? -13.31991 9.19576  -8.41994  1.000 13.69497 ? 265 VAL A CB  1 
ATOM   2067 C  CG1 . VAL A 1 265 ? -12.07519 8.56119  -7.83859  1.000 13.63533 ? 265 VAL A CG1 1 
ATOM   2068 C  CG2 . VAL A 1 265 ? -13.95235 10.15041 -7.41036  1.000 9.50639  ? 265 VAL A CG2 1 
ATOM   2069 N  N   . ASN A 1 266 ? -11.32741 9.01950  -11.23897 1.000 13.35765 ? 266 ASN A N   1 
ATOM   2070 C  CA  . ASN A 1 266 ? -10.87664 8.25942  -12.39658 1.000 15.97415 ? 266 ASN A CA  1 
ATOM   2071 C  C   . ASN A 1 266 ? -10.74371 6.77874  -12.04948 1.000 15.81742 ? 266 ASN A C   1 
ATOM   2072 O  O   . ASN A 1 266 ? -10.05050 6.40771  -11.09330 1.000 15.70030 ? 266 ASN A O   1 
ATOM   2073 C  CB  . ASN A 1 266 ? -9.56122  8.83837  -12.88220 1.000 13.26187 ? 266 ASN A CB  1 
ATOM   2074 C  CG  . ASN A 1 266 ? -9.72544  10.24344 -13.43732 1.000 16.80192 ? 266 ASN A CG  1 
ATOM   2075 O  OD1 . ASN A 1 266 ? -10.66425 10.51512 -14.18256 1.000 17.83353 ? 266 ASN A OD1 1 
ATOM   2076 N  ND2 . ASN A 1 266 ? -8.84349  11.15665 -13.02900 1.000 18.40550 ? 266 ASN A ND2 1 
ATOM   2077 N  N   . GLY A 1 267 ? -11.43255 5.93440  -12.80904 1.000 18.09579 ? 267 GLY A N   1 
ATOM   2078 C  CA  . GLY A 1 267 ? -11.35293 4.50201  -12.60840 1.000 15.29660 ? 267 GLY A CA  1 
ATOM   2079 C  C   . GLY A 1 267 ? -12.12194 3.96524  -11.41924 1.000 19.49851 ? 267 GLY A C   1 
ATOM   2080 O  O   . GLY A 1 267 ? -12.09524 2.74440  -11.18938 1.000 21.80876 ? 267 GLY A O   1 
ATOM   2081 N  N   . MET A 1 268 ? -12.78512 4.82757  -10.64190 1.000 17.23801 ? 268 MET A N   1 
ATOM   2082 C  CA  . MET A 1 268 ? -13.74029 4.35497  -9.64916  1.000 18.17041 ? 268 MET A CA  1 
ATOM   2083 C  C   . MET A 1 268 ? -14.92941 3.66912  -10.30867 1.000 14.81978 ? 268 MET A C   1 
ATOM   2084 O  O   . MET A 1 268 ? -15.43264 4.11685  -11.33901 1.000 14.98265 ? 268 MET A O   1 
ATOM   2085 C  CB  . MET A 1 268 ? -14.27872 5.50244  -8.79197  1.000 15.33569 ? 268 MET A CB  1 
ATOM   2086 C  CG  . MET A 1 268 ? -14.79578 5.02093  -7.44374  1.000 11.61399 ? 268 MET A CG  1 
ATOM   2087 S  SD  . MET A 1 268 ? -15.18452 6.33602  -6.28346  1.000 14.60882 ? 268 MET A SD  1 
ATOM   2088 C  CE  . MET A 1 268 ? -16.63337 7.04853  -7.06219  1.000 13.49806 ? 268 MET A CE  1 
ATOM   2089 N  N   . GLY A 1 269 ? -15.41135 2.61066  -9.68059  1.000 15.66133 ? 269 GLY A N   1 
ATOM   2090 C  CA  . GLY A 1 269 ? -16.66578 1.99567  -10.05726 1.000 15.99529 ? 269 GLY A CA  1 
ATOM   2091 C  C   . GLY A 1 269 ? -17.85180 2.60856  -9.34188  1.000 18.70722 ? 269 GLY A C   1 
ATOM   2092 O  O   . GLY A 1 269 ? -17.85051 3.78485  -8.95038  1.000 18.85722 ? 269 GLY A O   1 
ATOM   2093 N  N   . HIS A 1 270 ? -18.89005 1.80297  -9.18140  1.000 13.28083 ? 270 HIS A N   1 
ATOM   2094 C  CA  . HIS A 1 270 ? -20.09851 2.21979  -8.47896  1.000 16.29780 ? 270 HIS A CA  1 
ATOM   2095 C  C   . HIS A 1 270 ? -19.83953 2.08585  -6.98157  1.000 14.24244 ? 270 HIS A C   1 
ATOM   2096 O  O   . HIS A 1 270 ? -19.90510 0.99482  -6.41791  1.000 17.00179 ? 270 HIS A O   1 
ATOM   2097 C  CB  . HIS A 1 270 ? -21.27342 1.37414  -8.94612  1.000 16.82069 ? 270 HIS A CB  1 
ATOM   2098 C  CG  . HIS A 1 270 ? -22.61768 1.96084  -8.64053  1.000 14.93941 ? 270 HIS A CG  1 
ATOM   2099 N  ND1 . HIS A 1 270 ? -23.00150 3.21041  -9.07541  1.000 15.20284 ? 270 HIS A ND1 1 
ATOM   2100 C  CD2 . HIS A 1 270 ? -23.69026 1.43985  -7.99664  1.000 19.39143 ? 270 HIS A CD2 1 
ATOM   2101 C  CE1 . HIS A 1 270 ? -24.23743 3.45321  -8.67368  1.000 12.89424 ? 270 HIS A CE1 1 
ATOM   2102 N  NE2 . HIS A 1 270 ? -24.67813 2.39454  -8.01842  1.000 16.97759 ? 270 HIS A NE2 1 
ATOM   2103 N  N   . ALA A 1 271 ? -19.55062 3.20084  -6.32778  1.000 13.26034 ? 271 ALA A N   1 
ATOM   2104 C  CA  . ALA A 1 271 ? -19.03761 3.14584  -4.97438  1.000 12.41217 ? 271 ALA A CA  1 
ATOM   2105 C  C   . ALA A 1 271 ? -19.05329 4.53958  -4.36685  1.000 18.64669 ? 271 ALA A C   1 
ATOM   2106 O  O   . ALA A 1 271 ? -18.96738 5.54693  -5.07539  1.000 13.31424 ? 271 ALA A O   1 
ATOM   2107 C  CB  . ALA A 1 271 ? -17.60625 2.58436  -4.95767  1.000 12.18033 ? 271 ALA A CB  1 
ATOM   2108 N  N   . TRP A 1 272 ? -19.16005 4.57740  -3.04484  1.000 14.21075 ? 272 TRP A N   1 
ATOM   2109 C  CA  . TRP A 1 272 ? -18.90271 5.80074  -2.30894  1.000 12.66328 ? 272 TRP A CA  1 
ATOM   2110 C  C   . TRP A 1 272 ? -17.40257 6.06734  -2.31238  1.000 12.41713 ? 272 TRP A C   1 
ATOM   2111 O  O   . TRP A 1 272 ? -16.60888 5.18471  -1.97977  1.000 16.43337 ? 272 TRP A O   1 
ATOM   2112 C  CB  . TRP A 1 272 ? -19.41936 5.65969  -0.87650  1.000 13.52346 ? 272 TRP A CB  1 
ATOM   2113 C  CG  . TRP A 1 272 ? -19.44798 6.93204  -0.12169  1.000 13.19771 ? 272 TRP A CG  1 
ATOM   2114 C  CD1 . TRP A 1 272 ? -18.53070 7.36806  0.78322   1.000 12.31179 ? 272 TRP A CD1 1 
ATOM   2115 C  CD2 . TRP A 1 272 ? -20.44764 7.94461  -0.21002  1.000 10.63271 ? 272 TRP A CD2 1 
ATOM   2116 N  NE1 . TRP A 1 272 ? -18.90123 8.60868  1.27366   1.000 13.35196 ? 272 TRP A NE1 1 
ATOM   2117 C  CE2 . TRP A 1 272 ? -20.07842 8.97771  0.67894   1.000 13.32420 ? 272 TRP A CE2 1 
ATOM   2118 C  CE3 . TRP A 1 272 ? -21.62786 8.07762  -0.95180  1.000 13.67294 ? 272 TRP A CE3 1 
ATOM   2119 C  CZ2 . TRP A 1 272 ? -20.85259 10.12800 0.85113   1.000 13.26893 ? 272 TRP A CZ2 1 
ATOM   2120 C  CZ3 . TRP A 1 272 ? -22.38358 9.21844  -0.78626  1.000 15.35148 ? 272 TRP A CZ3 1 
ATOM   2121 C  CH2 . TRP A 1 272 ? -21.99377 10.23009 0.10265   1.000 16.03199 ? 272 TRP A CH2 1 
ATOM   2122 N  N   . SER A 1 273 ? -17.00994 7.27150  -2.69962  1.000 12.84779 ? 273 SER A N   1 
ATOM   2123 C  CA  . SER A 1 273 ? -15.58885 7.56786  -2.82921  1.000 12.11492 ? 273 SER A CA  1 
ATOM   2124 C  C   . SER A 1 273 ? -14.95370 7.72242  -1.45650  1.000 18.19404 ? 273 SER A C   1 
ATOM   2125 O  O   . SER A 1 273 ? -15.46258 8.46074  -0.60703  1.000 12.75482 ? 273 SER A O   1 
ATOM   2126 C  CB  . SER A 1 273 ? -15.38724 8.83535  -3.65045  1.000 13.89868 ? 273 SER A CB  1 
ATOM   2127 O  OG  . SER A 1 273 ? -14.00925 9.04667  -3.92385  1.000 16.51891 ? 273 SER A OG  1 
ATOM   2128 N  N   . GLY A 1 274 ? -13.82673 7.03708  -1.24927  1.000 12.48929 ? 274 GLY A N   1 
ATOM   2129 C  CA  . GLY A 1 274 ? -13.20106 7.01318  0.05553   1.000 12.05871 ? 274 GLY A CA  1 
ATOM   2130 C  C   . GLY A 1 274 ? -13.95436 6.05922  0.96814   1.000 21.80032 ? 274 GLY A C   1 
ATOM   2131 O  O   . GLY A 1 274 ? -14.53825 5.06863  0.52871   1.000 24.78593 ? 274 GLY A O   1 
ATOM   2132 N  N   . GLY A 1 275 ? -13.95458 6.36958  2.24727   1.000 23.93747 ? 275 GLY A N   1 
ATOM   2133 C  CA  . GLY A 1 275 ? -14.72184 5.54246  3.14899   1.000 17.96688 ? 275 GLY A CA  1 
ATOM   2134 C  C   . GLY A 1 275 ? -13.94487 4.31021  3.57823   1.000 22.35533 ? 275 GLY A C   1 
ATOM   2135 O  O   . GLY A 1 275 ? -12.71739 4.21912  3.44967   1.000 24.44927 ? 275 GLY A O   1 
ATOM   2136 N  N   . SER A 1 276 ? -14.68271 3.34464  4.09742   1.000 16.14173 ? 276 SER A N   1 
ATOM   2137 C  CA  . SER A 1 276 ? -14.07056 2.20266  4.75223   1.000 16.55053 ? 276 SER A CA  1 
ATOM   2138 C  C   . SER A 1 276 ? -14.61712 0.91369  4.15595   1.000 16.57541 ? 276 SER A C   1 
ATOM   2139 O  O   . SER A 1 276 ? -15.77591 0.84382  3.74075   1.000 16.50043 ? 276 SER A O   1 
ATOM   2140 C  CB  . SER A 1 276 ? -14.32386 2.23619  6.25697   1.000 14.82333 ? 276 SER A CB  1 
ATOM   2141 O  OG  . SER A 1 276 ? -14.05214 0.97032  6.84847   1.000 18.30777 ? 276 SER A OG  1 
ATOM   2142 N  N   . THR A 1 277 ? -13.77210 -0.11271 4.13051   1.000 21.97441 ? 277 THR A N   1 
ATOM   2143 C  CA  . THR A 1 277 ? -14.22417 -1.43890 3.72756   1.000 17.17149 ? 277 THR A CA  1 
ATOM   2144 C  C   . THR A 1 277 ? -15.14065 -2.07230 4.76271   1.000 16.43664 ? 277 THR A C   1 
ATOM   2145 O  O   . THR A 1 277 ? -15.70322 -3.13985 4.49404   1.000 16.10520 ? 277 THR A O   1 
ATOM   2146 C  CB  . THR A 1 277 ? -13.02078 -2.34668 3.46599   1.000 18.53608 ? 277 THR A CB  1 
ATOM   2147 O  OG1 . THR A 1 277 ? -12.22535 -2.41479 4.64957   1.000 24.71922 ? 277 THR A OG1 1 
ATOM   2148 C  CG2 . THR A 1 277 ? -12.17939 -1.78768 2.32270   1.000 28.36654 ? 277 THR A CG2 1 
ATOM   2149 N  N   . ALA A 1 278 ? -15.29607 -1.44229 5.93371   1.000 15.16615 ? 278 ALA A N   1 
ATOM   2150 C  CA  . ALA A 1 278 ? -16.28205 -1.89425 6.90457   1.000 13.78785 ? 278 ALA A CA  1 
ATOM   2151 C  C   . ALA A 1 278 ? -17.69313 -1.88356 6.32787   1.000 21.32473 ? 278 ALA A C   1 
ATOM   2152 O  O   . ALA A 1 278 ? -18.55727 -2.59755 6.84301   1.000 16.16745 ? 278 ALA A O   1 
ATOM   2153 C  CB  . ALA A 1 278 ? -16.23826 -1.02224 8.16744   1.000 15.59247 ? 278 ALA A CB  1 
ATOM   2154 N  N   . GLY A 1 279 ? -17.94857 -1.08382 5.28434   1.000 13.02026 ? 279 GLY A N   1 
ATOM   2155 C  CA  . GLY A 1 279 ? -19.23324 -1.10459 4.60377   1.000 13.60303 ? 279 GLY A CA  1 
ATOM   2156 C  C   . GLY A 1 279 ? -19.13534 -1.50608 3.14353   1.000 15.81108 ? 279 GLY A C   1 
ATOM   2157 O  O   . GLY A 1 279 ? -18.06560 -1.39690 2.53151   1.000 18.42675 ? 279 GLY A O   1 
ATOM   2158 N  N   . THR A 1 280 ? -20.24135 -1.97448 2.56803   1.000 14.73462 ? 280 THR A N   1 
ATOM   2159 C  CA  . THR A 1 280 ? -20.24726 -2.28487 1.14385   1.000 18.35374 ? 280 THR A CA  1 
ATOM   2160 C  C   . THR A 1 280 ? -20.19297 -1.00208 0.31624   1.000 17.54056 ? 280 THR A C   1 
ATOM   2161 O  O   . THR A 1 280 ? -20.47349 0.09628  0.80622   1.000 19.98011 ? 280 THR A O   1 
ATOM   2162 C  CB  . THR A 1 280 ? -21.49850 -3.08096 0.76686   1.000 13.61547 ? 280 THR A CB  1 
ATOM   2163 O  OG1 . THR A 1 280 ? -22.65645 -2.27155 1.01100   1.000 14.76972 ? 280 THR A OG1 1 
ATOM   2164 C  CG2 . THR A 1 280 ? -21.59714 -4.37081 1.60050   1.000 14.66721 ? 280 THR A CG2 1 
ATOM   2165 N  N   . TYR A 1 281 ? -19.83025 -1.15325 -0.96050  1.000 12.41925 ? 281 TYR A N   1 
ATOM   2166 C  CA  . TYR A 1 281 ? -19.98593 -0.07469 -1.93674  1.000 14.43411 ? 281 TYR A CA  1 
ATOM   2167 C  C   . TYR A 1 281 ? -19.14779 1.15153  -1.57902  1.000 12.70006 ? 281 TYR A C   1 
ATOM   2168 O  O   . TYR A 1 281 ? -19.61616 2.29257  -1.65230  1.000 14.41115 ? 281 TYR A O   1 
ATOM   2169 C  CB  . TYR A 1 281 ? -21.46228 0.30227  -2.10026  1.000 14.70283 ? 281 TYR A CB  1 
ATOM   2170 C  CG  . TYR A 1 281 ? -22.13338 -0.53597 -3.17258  1.000 19.59659 ? 281 TYR A CG  1 
ATOM   2171 C  CD1 . TYR A 1 281 ? -21.91853 -0.25982 -4.51444  1.000 24.65468 ? 281 TYR A CD1 1 
ATOM   2172 C  CD2 . TYR A 1 281 ? -22.97621 -1.59751 -2.85012  1.000 19.43738 ? 281 TYR A CD2 1 
ATOM   2173 C  CE1 . TYR A 1 281 ? -22.49893 -1.01427 -5.50653  1.000 21.01003 ? 281 TYR A CE1 1 
ATOM   2174 C  CE2 . TYR A 1 281 ? -23.58613 -2.35320 -3.85453  1.000 16.14905 ? 281 TYR A CE2 1 
ATOM   2175 C  CZ  . TYR A 1 281 ? -23.33153 -2.05058 -5.18295  1.000 24.05103 ? 281 TYR A CZ  1 
ATOM   2176 O  OH  . TYR A 1 281 ? -23.90093 -2.77594 -6.21446  1.000 19.99385 ? 281 TYR A OH  1 
ATOM   2177 N  N   . THR A 1 282 ? -17.89942 0.91606  -1.19072  1.000 11.18878 ? 282 THR A N   1 
ATOM   2178 C  CA  . THR A 1 282 ? -16.94159 1.98546  -0.95487  1.000 14.97922 ? 282 THR A CA  1 
ATOM   2179 C  C   . THR A 1 282 ? -15.69437 1.71784  -1.77696  1.000 19.38963 ? 282 THR A C   1 
ATOM   2180 O  O   . THR A 1 282 ? -15.35858 0.56978  -2.06914  1.000 14.67761 ? 282 THR A O   1 
ATOM   2181 C  CB  . THR A 1 282 ? -16.53821 2.09383  0.53240   1.000 17.94563 ? 282 THR A CB  1 
ATOM   2182 O  OG1 . THR A 1 282 ? -15.91036 0.87225  0.94513   1.000 18.62192 ? 282 THR A OG1 1 
ATOM   2183 C  CG2 . THR A 1 282 ? -17.72502 2.35821  1.40915   1.000 11.70496 ? 282 THR A CG2 1 
ATOM   2184 N  N   . ASP A 1 283 ? -14.99066 2.78936  -2.11919  1.000 13.99534 ? 283 ASP A N   1 
ATOM   2185 C  CA  . ASP A 1 283 ? -13.67718 2.69851  -2.74487  1.000 16.23223 ? 283 ASP A CA  1 
ATOM   2186 C  C   . ASP A 1 283 ? -12.71251 3.52129  -1.90867  1.000 17.13440 ? 283 ASP A C   1 
ATOM   2187 O  O   . ASP A 1 283 ? -12.58676 4.74172  -2.10365  1.000 14.86503 ? 283 ASP A O   1 
ATOM   2188 C  CB  . ASP A 1 283 ? -13.71680 3.18070  -4.18239  1.000 14.20461 ? 283 ASP A CB  1 
ATOM   2189 C  CG  . ASP A 1 283 ? -12.40533 2.97000  -4.88295  1.000 20.68413 ? 283 ASP A CG  1 
ATOM   2190 O  OD1 . ASP A 1 283 ? -11.40659 2.65099  -4.19144  1.000 19.20856 ? 283 ASP A OD1 1 
ATOM   2191 O  OD2 . ASP A 1 283 ? -12.38101 3.12644  -6.11863  1.000 21.17778 ? 283 ASP A OD2 1 
ATOM   2192 N  N   . PRO A 1 284 ? -12.02060 2.88499  -0.95863  1.000 18.07670 ? 284 PRO A N   1 
ATOM   2193 C  CA  . PRO A 1 284 ? -11.12348 3.63223  -0.06395  1.000 19.61227 ? 284 PRO A CA  1 
ATOM   2194 C  C   . PRO A 1 284 ? -10.03471 4.39845  -0.77959  1.000 19.33852 ? 284 PRO A C   1 
ATOM   2195 O  O   . PRO A 1 284 ? -9.42303  5.28599  -0.17259  1.000 22.92726 ? 284 PRO A O   1 
ATOM   2196 C  CB  . PRO A 1 284 ? -10.53012 2.53326  0.83532   1.000 20.38921 ? 284 PRO A CB  1 
ATOM   2197 C  CG  . PRO A 1 284 ? -11.57052 1.44132  0.83487   1.000 21.66744 ? 284 PRO A CG  1 
ATOM   2198 C  CD  . PRO A 1 284 ? -12.19723 1.47892  -0.53342  1.000 20.16661 ? 284 PRO A CD  1 
ATOM   2199 N  N   . ALA A 1 285 ? -9.75223  4.08326  -2.03355  1.000 15.14824 ? 285 ALA A N   1 
ATOM   2200 C  CA  . ALA A 1 285 ? -8.71166  4.79406  -2.76060  1.000 13.48364 ? 285 ALA A CA  1 
ATOM   2201 C  C   . ALA A 1 285 ? -9.21057  6.07751  -3.41410  1.000 17.43921 ? 285 ALA A C   1 
ATOM   2202 O  O   . ALA A 1 285 ? -8.39454  6.84473  -3.93678  1.000 16.77197 ? 285 ALA A O   1 
ATOM   2203 C  CB  . ALA A 1 285 ? -8.08431  3.87988  -3.81801  1.000 13.67877 ? 285 ALA A CB  1 
ATOM   2204 N  N   . GLY A 1 286 ? -10.51596 6.34513  -3.39085  1.000 19.39944 ? 286 GLY A N   1 
ATOM   2205 C  CA  . GLY A 1 286 ? -11.00470 7.61803  -3.88059  1.000 13.31716 ? 286 GLY A CA  1 
ATOM   2206 C  C   . GLY A 1 286 ? -10.80050 8.71514  -2.86478  1.000 13.93713 ? 286 GLY A C   1 
ATOM   2207 O  O   . GLY A 1 286 ? -10.50131 8.47615  -1.68010  1.000 12.74213 ? 286 GLY A O   1 
ATOM   2208 N  N   . PRO A 1 287 ? -10.98359 9.96082  -3.30427  1.000 13.94280 ? 287 PRO A N   1 
ATOM   2209 C  CA  . PRO A 1 287 ? -11.04438 11.05939 -2.33551  1.000 13.97337 ? 287 PRO A CA  1 
ATOM   2210 C  C   . PRO A 1 287 ? -12.21684 10.86217 -1.38773  1.000 14.78852 ? 287 PRO A C   1 
ATOM   2211 O  O   . PRO A 1 287 ? -13.16826 10.13136 -1.67872  1.000 15.10242 ? 287 PRO A O   1 
ATOM   2212 C  CB  . PRO A 1 287 ? -11.22337 12.30596 -3.20595  1.000 19.61718 ? 287 PRO A CB  1 
ATOM   2213 C  CG  . PRO A 1 287 ? -11.85067 11.79602 -4.44754  1.000 16.41884 ? 287 PRO A CG  1 
ATOM   2214 C  CD  . PRO A 1 287 ? -11.25643 10.42000 -4.67299  1.000 12.93206 ? 287 PRO A CD  1 
ATOM   2215 N  N   . GLU A 1 288 ? -12.13649 11.51454 -0.22819  1.000 13.86968 ? 288 GLU A N   1 
ATOM   2216 C  CA  . GLU A 1 288 ? -13.08560 11.26288 0.85642   1.000 13.93633 ? 288 GLU A CA  1 
ATOM   2217 C  C   . GLU A 1 288 ? -14.37319 12.04646 0.60641   1.000 12.16160 ? 288 GLU A C   1 
ATOM   2218 O  O   . GLU A 1 288 ? -14.51974 13.19759 1.01477   1.000 15.91230 ? 288 GLU A O   1 
ATOM   2219 C  CB  . GLU A 1 288 ? -12.46519 11.61307 2.20054   1.000 13.19376 ? 288 GLU A CB  1 
ATOM   2220 C  CG  . GLU A 1 288 ? -11.18030 10.82203 2.49048   1.000 18.18847 ? 288 GLU A CG  1 
ATOM   2221 C  CD  . GLU A 1 288 ? -11.43201 9.32631  2.75033   1.000 27.92713 ? 288 GLU A CD  1 
ATOM   2222 O  OE1 . GLU A 1 288 ? -12.58046 8.94734  3.06434   1.000 23.03237 ? 288 GLU A OE1 1 
ATOM   2223 O  OE2 . GLU A 1 288 ? -10.47389 8.52115  2.64571   1.000 34.46743 ? 288 GLU A OE2 1 
ATOM   2224 N  N   . ALA A 1 289 ? -15.33166 11.38522 -0.05266  1.000 14.00402 ? 289 ALA A N   1 
ATOM   2225 C  CA  . ALA A 1 289 ? -16.60934 12.02724 -0.36087  1.000 14.00311 ? 289 ALA A CA  1 
ATOM   2226 C  C   . ALA A 1 289 ? -17.31071 12.52450 0.89666   1.000 14.45350 ? 289 ALA A C   1 
ATOM   2227 O  O   . ALA A 1 289 ? -17.93618 13.58790 0.88373   1.000 12.19513 ? 289 ALA A O   1 
ATOM   2228 C  CB  . ALA A 1 289 ? -17.52095 11.06007 -1.12797  1.000 11.45178 ? 289 ALA A CB  1 
ATOM   2229 N  N   . SER A 1 290 ? -17.24098 11.76577 1.99251   1.000 13.06244 ? 290 SER A N   1 
ATOM   2230 C  CA  . SER A 1 290 ? -17.95871 12.18507 3.19815   1.000 13.42749 ? 290 SER A CA  1 
ATOM   2231 C  C   . SER A 1 290 ? -17.43600 13.52742 3.72268   1.000 12.69534 ? 290 SER A C   1 
ATOM   2232 O  O   . SER A 1 290 ? -18.22054 14.40182 4.12163   1.000 12.64810 ? 290 SER A O   1 
ATOM   2233 C  CB  . SER A 1 290 ? -17.86035 11.09402 4.27414   1.000 14.78240 ? 290 SER A CB  1 
ATOM   2234 O  OG  . SER A 1 290 ? -18.63723 9.95265  3.93549   1.000 12.84586 ? 290 SER A OG  1 
ATOM   2235 N  N   . SER A 1 291 ? -16.11206 13.70770 3.73950   1.000 12.86910 ? 291 SER A N   1 
ATOM   2236 C  CA  A SER A 1 291 ? -15.53955 14.97088 4.19209   0.780 18.72011 ? 291 SER A CA  1 
ATOM   2237 C  CA  B SER A 1 291 ? -15.55564 14.97427 4.20283   0.220 18.53398 ? 291 SER A CA  1 
ATOM   2238 C  C   . SER A 1 291 ? -15.83135 16.08847 3.19927   1.000 14.52339 ? 291 SER A C   1 
ATOM   2239 O  O   . SER A 1 291 ? -16.24064 17.19081 3.58310   1.000 12.99460 ? 291 SER A O   1 
ATOM   2240 C  CB  A SER A 1 291 ? -14.03485 14.82148 4.38812   0.780 14.90507 ? 291 SER A CB  1 
ATOM   2241 C  CB  B SER A 1 291 ? -14.05460 14.83260 4.46135   0.220 15.09117 ? 291 SER A CB  1 
ATOM   2242 O  OG  A SER A 1 291 ? -13.47958 16.07065 4.73060   0.780 19.06723 ? 291 SER A OG  1 
ATOM   2243 O  OG  B SER A 1 291 ? -13.34749 14.57046 3.26680   0.220 15.67114 ? 291 SER A OG  1 
ATOM   2244 N  N   . MET A 1 292 ? -15.60635 15.81518 1.91304   1.000 14.82575 ? 292 MET A N   1 
ATOM   2245 C  CA  . MET A 1 292 ? -15.85678 16.78589 0.84500   1.000 12.60073 ? 292 MET A CA  1 
ATOM   2246 C  C   . MET A 1 292 ? -17.30990 17.22571 0.81956   1.000 14.55079 ? 292 MET A C   1 
ATOM   2247 O  O   . MET A 1 292 ? -17.61592 18.41821 0.67536   1.000 13.95354 ? 292 MET A O   1 
ATOM   2248 C  CB  . MET A 1 292 ? -15.48344 16.12811 -0.47201  1.000 11.79076 ? 292 MET A CB  1 
ATOM   2249 C  CG  . MET A 1 292 ? -13.98821 15.98861 -0.66454  1.000 13.69763 ? 292 MET A CG  1 
ATOM   2250 S  SD  . MET A 1 292 ? -13.67072 14.88260 -2.05145  1.000 21.21881 ? 292 MET A SD  1 
ATOM   2251 C  CE  . MET A 1 292 ? -12.69964 15.97067 -3.10321  1.000 22.00018 ? 292 MET A CE  1 
ATOM   2252 N  N   . MET A 1 293 ? -18.21873 16.27332 0.96251   1.000 11.69556 ? 293 MET A N   1 
ATOM   2253 C  CA  A MET A 1 293 ? -19.63706 16.59743 0.95283   0.648 10.39493 ? 293 MET A CA  1 
ATOM   2254 C  CA  B MET A 1 293 ? -19.63041 16.61239 0.94719   0.352 10.43347 ? 293 MET A CA  1 
ATOM   2255 C  C   . MET A 1 293 ? -20.02426 17.39550 2.19251   1.000 12.93600 ? 293 MET A C   1 
ATOM   2256 O  O   . MET A 1 293 ? -20.79327 18.35857 2.10483   1.000 10.81930 ? 293 MET A O   1 
ATOM   2257 C  CB  A MET A 1 293 ? -20.44507 15.29999 0.85556   0.648 9.98858  ? 293 MET A CB  1 
ATOM   2258 C  CB  B MET A 1 293 ? -20.46084 15.34317 0.82557   0.352 10.03105 ? 293 MET A CB  1 
ATOM   2259 C  CG  A MET A 1 293 ? -20.82614 14.93322 -0.55810  0.648 14.16933 ? 293 MET A CG  1 
ATOM   2260 C  CG  B MET A 1 293 ? -21.92190 15.60530 0.81620   0.352 11.02351 ? 293 MET A CG  1 
ATOM   2261 S  SD  A MET A 1 293 ? -22.08187 13.63186 -0.60211  0.648 15.54036 ? 293 MET A SD  1 
ATOM   2262 S  SD  B MET A 1 293 ? -22.78359 14.04574 0.65989   0.352 13.29898 ? 293 MET A SD  1 
ATOM   2263 C  CE  A MET A 1 293 ? -21.58209 12.70261 -2.03308  0.648 15.91551 ? 293 MET A CE  1 
ATOM   2264 C  CE  B MET A 1 293 ? -22.60322 13.40888 2.32314   0.352 7.94803  ? 293 MET A CE  1 
ATOM   2265 N  N   . TRP A 1 294 ? -19.50834 16.99930 3.36152   1.000 10.70361 ? 294 TRP A N   1 
ATOM   2266 C  CA  . TRP A 1 294 ? -19.80928 17.74877 4.57518   1.000 8.90420  ? 294 TRP A CA  1 
ATOM   2267 C  C   . TRP A 1 294 ? -19.31856 19.18763 4.46823   1.000 13.77089 ? 294 TRP A C   1 
ATOM   2268 O  O   . TRP A 1 294 ? -20.00484 20.11979 4.89964   1.000 14.50254 ? 294 TRP A O   1 
ATOM   2269 C  CB  . TRP A 1 294 ? -19.18438 17.10089 5.81195   1.000 13.19366 ? 294 TRP A CB  1 
ATOM   2270 C  CG  . TRP A 1 294 ? -19.41366 18.01069 6.98451   1.000 15.35893 ? 294 TRP A CG  1 
ATOM   2271 C  CD1 . TRP A 1 294 ? -18.47251 18.66287 7.72872   1.000 18.91861 ? 294 TRP A CD1 1 
ATOM   2272 C  CD2 . TRP A 1 294 ? -20.68684 18.43303 7.48054   1.000 13.39716 ? 294 TRP A CD2 1 
ATOM   2273 N  NE1 . TRP A 1 294 ? -19.08933 19.45336 8.68036   1.000 16.78795 ? 294 TRP A NE1 1 
ATOM   2274 C  CE2 . TRP A 1 294 ? -20.44661 19.33453 8.54075   1.000 15.30094 ? 294 TRP A CE2 1 
ATOM   2275 C  CE3 . TRP A 1 294 ? -22.00912 18.13385 7.12839   1.000 11.30974 ? 294 TRP A CE3 1 
ATOM   2276 C  CZ2 . TRP A 1 294 ? -21.47742 19.93131 9.26185   1.000 15.81799 ? 294 TRP A CZ2 1 
ATOM   2277 C  CZ3 . TRP A 1 294 ? -23.03729 18.72776 7.84875   1.000 19.88962 ? 294 TRP A CZ3 1 
ATOM   2278 C  CH2 . TRP A 1 294 ? -22.76366 19.61448 8.90385   1.000 13.26967 ? 294 TRP A CH2 1 
ATOM   2279 N  N   . SER A 1 295 ? -18.10772 19.38637 3.94521   1.000 14.58881 ? 295 SER A N   1 
ATOM   2280 C  CA  . SER A 1 295 ? -17.61907 20.74980 3.77669   1.000 18.06322 ? 295 SER A CA  1 
ATOM   2281 C  C   . SER A 1 295 ? -18.49095 21.53272 2.80779   1.000 13.51081 ? 295 SER A C   1 
ATOM   2282 O  O   . SER A 1 295 ? -18.80341 22.70537 3.04882   1.000 15.31973 ? 295 SER A O   1 
ATOM   2283 C  CB  . SER A 1 295 ? -16.17826 20.75592 3.28681   1.000 13.11868 ? 295 SER A CB  1 
ATOM   2284 O  OG  . SER A 1 295 ? -15.74465 22.10191 3.29664   1.000 25.21928 ? 295 SER A OG  1 
ATOM   2285 N  N   . PHE A 1 296 ? -18.87702 20.91589 1.69383   1.000 10.42394 ? 296 PHE A N   1 
ATOM   2286 C  CA  . PHE A 1 296 ? -19.81240 21.58658 0.79959   1.000 13.43756 ? 296 PHE A CA  1 
ATOM   2287 C  C   . PHE A 1 296 ? -21.10633 21.95055 1.53691   1.000 13.39147 ? 296 PHE A C   1 
ATOM   2288 O  O   . PHE A 1 296 ? -21.60685 23.07132 1.41801   1.000 10.48863 ? 296 PHE A O   1 
ATOM   2289 C  CB  . PHE A 1 296 ? -20.07949 20.69810 -0.42237  1.000 10.67396 ? 296 PHE A CB  1 
ATOM   2290 C  CG  . PHE A 1 296 ? -20.97583 21.33474 -1.45807  1.000 10.71907 ? 296 PHE A CG  1 
ATOM   2291 C  CD1 . PHE A 1 296 ? -20.43856 22.13558 -2.46481  1.000 12.53954 ? 296 PHE A CD1 1 
ATOM   2292 C  CD2 . PHE A 1 296 ? -22.34266 21.09916 -1.45151  1.000 11.37218 ? 296 PHE A CD2 1 
ATOM   2293 C  CE1 . PHE A 1 296 ? -21.25399 22.70585 -3.43146  1.000 13.54731 ? 296 PHE A CE1 1 
ATOM   2294 C  CE2 . PHE A 1 296 ? -23.17000 21.66079 -2.40100  1.000 13.47797 ? 296 PHE A CE2 1 
ATOM   2295 C  CZ  . PHE A 1 296 ? -22.63189 22.48252 -3.39589  1.000 12.33589 ? 296 PHE A CZ  1 
ATOM   2296 N  N   . PHE A 1 297 ? -21.65110 21.01817 2.32537   1.000 17.08035 ? 297 PHE A N   1 
ATOM   2297 C  CA  . PHE A 1 297 ? -22.92385 21.26487 3.00941   1.000 13.58883 ? 297 PHE A CA  1 
ATOM   2298 C  C   . PHE A 1 297 ? -22.80671 22.42769 3.99245   1.000 14.37769 ? 297 PHE A C   1 
ATOM   2299 O  O   . PHE A 1 297 ? -23.63890 23.34851 4.00047   1.000 13.07073 ? 297 PHE A O   1 
ATOM   2300 C  CB  . PHE A 1 297 ? -23.37245 20.00313 3.75626   1.000 11.86977 ? 297 PHE A CB  1 
ATOM   2301 C  CG  . PHE A 1 297 ? -23.89269 18.89928 2.86914   1.000 14.22344 ? 297 PHE A CG  1 
ATOM   2302 C  CD1 . PHE A 1 297 ? -24.21895 19.12556 1.54883   1.000 14.52202 ? 297 PHE A CD1 1 
ATOM   2303 C  CD2 . PHE A 1 297 ? -24.05416 17.62011 3.37511   1.000 9.54412  ? 297 PHE A CD2 1 
ATOM   2304 C  CE1 . PHE A 1 297 ? -24.69980 18.09374 0.75100   1.000 12.08794 ? 297 PHE A CE1 1 
ATOM   2305 C  CE2 . PHE A 1 297 ? -24.52926 16.59119 2.58872   1.000 13.21635 ? 297 PHE A CE2 1 
ATOM   2306 C  CZ  . PHE A 1 297 ? -24.85520 16.82198 1.27348   1.000 16.24244 ? 297 PHE A CZ  1 
ATOM   2307 N  N   . VAL A 1 298 ? -21.79139 22.38720 4.85700   1.000 13.50751 ? 298 VAL A N   1 
ATOM   2308 C  CA  . VAL A 1 298 ? -21.72257 23.35429 5.93670   1.000 18.46760 ? 298 VAL A CA  1 
ATOM   2309 C  C   . VAL A 1 298 ? -21.50361 24.75707 5.38183   1.000 15.98026 ? 298 VAL A C   1 
ATOM   2310 O  O   . VAL A 1 298 ? -21.90675 25.75807 5.99606   1.000 15.29449 ? 298 VAL A O   1 
ATOM   2311 C  CB  . VAL A 1 298 ? -20.64782 22.87703 6.94001   1.000 18.59100 ? 298 VAL A CB  1 
ATOM   2312 C  CG1 . VAL A 1 298 ? -19.25890 23.34374 6.54788   1.000 25.37024 ? 298 VAL A CG1 1 
ATOM   2313 C  CG2 . VAL A 1 298 ? -21.01868 23.27100 8.35549   1.000 26.66708 ? 298 VAL A CG2 1 
ATOM   2314 N  N   . ASN A 1 299 ? -20.92561 24.85602 4.19950   1.000 13.96586 ? 299 ASN A N   1 
ATOM   2315 C  CA  . ASN A 1 299 ? -20.73312 26.13976 3.55245   1.000 13.10100 ? 299 ASN A CA  1 
ATOM   2316 C  C   . ASN A 1 299 ? -21.87770 26.51329 2.63066   1.000 19.68491 ? 299 ASN A C   1 
ATOM   2317 O  O   . ASN A 1 299 ? -21.77860 27.51524 1.91860   1.000 14.40491 ? 299 ASN A O   1 
ATOM   2318 C  CB  . ASN A 1 299 ? -19.40452 26.12754 2.80247   1.000 11.24591 ? 299 ASN A CB  1 
ATOM   2319 C  CG  . ASN A 1 299 ? -18.22882 26.16345 3.75080   1.000 20.09317 ? 299 ASN A CG  1 
ATOM   2320 O  OD1 . ASN A 1 299 ? -17.95644 27.19931 4.36431   1.000 22.23526 ? 299 ASN A OD1 1 
ATOM   2321 N  ND2 . ASN A 1 299 ? -17.56401 25.02423 3.93263   1.000 17.83638 ? 299 ASN A ND2 1 
ATOM   2322 N  N   . HIS A 1 300 ? -22.96021 25.73829 2.62563   1.000 10.73380 ? 300 HIS A N   1 
ATOM   2323 C  CA  . HIS A 1 300 ? -24.15177 26.04904 1.83622   1.000 12.36972 ? 300 HIS A CA  1 
ATOM   2324 C  C   . HIS A 1 300 ? -25.40364 25.87050 2.68579   1.000 11.34965 ? 300 HIS A C   1 
ATOM   2325 O  O   . HIS A 1 300 ? -26.29426 25.07944 2.35385   1.000 16.11353 ? 300 HIS A O   1 
ATOM   2326 C  CB  . HIS A 1 300 ? -24.18894 25.17739 0.58256   1.000 11.66352 ? 300 HIS A CB  1 
ATOM   2327 C  CG  . HIS A 1 300 ? -23.10919 25.52590 -0.39872  1.000 10.20969 ? 300 HIS A CG  1 
ATOM   2328 N  ND1 . HIS A 1 300 ? -21.84796 24.97274 -0.34288  1.000 16.41522 ? 300 HIS A ND1 1 
ATOM   2329 C  CD2 . HIS A 1 300 ? -23.07699 26.43552 -1.40441  1.000 12.99251 ? 300 HIS A CD2 1 
ATOM   2330 C  CE1 . HIS A 1 300 ? -21.09823 25.49596 -1.29734  1.000 16.61749 ? 300 HIS A CE1 1 
ATOM   2331 N  NE2 . HIS A 1 300 ? -21.81955 26.38826 -1.95172  1.000 15.79046 ? 300 HIS A NE2 1 
ATOM   2332 N  N   . PRO A 1 301 ? -25.50838 26.61007 3.78864   1.000 14.93927 ? 301 PRO A N   1 
ATOM   2333 C  CA  . PRO A 1 301 ? -26.74334 26.58750 4.57181   1.000 13.79133 ? 301 PRO A CA  1 
ATOM   2334 C  C   . PRO A 1 301 ? -27.88810 27.18914 3.76706   1.000 18.68950 ? 301 PRO A C   1 
ATOM   2335 O  O   . PRO A 1 301 ? -27.69179 27.84449 2.74013   1.000 17.89426 ? 301 PRO A O   1 
ATOM   2336 C  CB  . PRO A 1 301 ? -26.39724 27.43508 5.80159   1.000 13.38552 ? 301 PRO A CB  1 
ATOM   2337 C  CG  . PRO A 1 301 ? -25.35543 28.39374 5.29962   1.000 18.36040 ? 301 PRO A CG  1 
ATOM   2338 C  CD  . PRO A 1 301 ? -24.54902 27.60865 4.29748   1.000 13.09960 ? 301 PRO A CD  1 
ATOM   2339 N  N   . LYS A 1 302 ? -29.10175 26.93385 4.23412   1.000 17.20096 ? 302 LYS A N   1 
ATOM   2340 C  CA  . LYS A 1 302 ? -30.29778 27.35533 3.50006   1.000 19.81359 ? 302 LYS A CA  1 
ATOM   2341 C  C   . LYS A 1 302 ? -30.32317 28.86732 3.30495   1.000 26.40845 ? 302 LYS A C   1 
ATOM   2342 O  O   . LYS A 1 302 ? -30.30238 29.63634 4.26111   1.000 31.55838 ? 302 LYS A O   1 
ATOM   2343 C  CB  . LYS A 1 302 ? -31.57496 26.89538 4.21492   1.000 13.70967 ? 302 LYS A CB  1 
ATOM   2344 C  CG  . LYS A 1 302 ? -32.70485 26.52143 3.28476   1.000 21.68429 ? 302 LYS A CG  1 
ATOM   2345 C  CD  . LYS A 1 302 ? -33.95529 26.07239 4.04933   1.000 18.42623 ? 302 LYS A CD  1 
ATOM   2346 C  CE  . LYS A 1 302 ? -35.19058 26.78608 3.49731   1.000 25.32531 ? 302 LYS A CE  1 
ATOM   2347 N  NZ  . LYS A 1 302 ? -36.31280 26.87660 4.47498   1.000 18.71240 ? 302 LYS A NZ  1 
ATOM   2348 O  OXT . LYS A 1 302 ? -30.35823 29.35848 2.17760   1.000 33.87303 ? 302 LYS A OXT 1 
HETATM 2349 C  C   . TRS B 2 .   ? -31.32919 36.32750 -15.15831 1.000 40.00360 ? 401 TRS A C   1 
HETATM 2350 C  C1  . TRS B 2 .   ? -32.29519 36.53057 -13.95470 1.000 54.79092 ? 401 TRS A C1  1 
HETATM 2351 C  C2  . TRS B 2 .   ? -31.36140 34.82498 -15.54799 1.000 50.95304 ? 401 TRS A C2  1 
HETATM 2352 C  C3  . TRS B 2 .   ? -29.90710 36.62397 -14.64309 1.000 57.46060 ? 401 TRS A C3  1 
HETATM 2353 N  N   . TRS B 2 .   ? -31.80295 37.27284 -16.39774 1.000 39.12538 ? 401 TRS A N   1 
HETATM 2354 O  O1  . TRS B 2 .   ? -32.28649 37.89836 -13.58376 1.000 48.00839 ? 401 TRS A O1  1 
HETATM 2355 O  O2  . TRS B 2 .   ? -30.51862 34.65736 -16.67328 1.000 38.01639 ? 401 TRS A O2  1 
HETATM 2356 O  O3  . TRS B 2 .   ? -29.67400 37.99513 -14.87154 1.000 49.14469 ? 401 TRS A O3  1 
HETATM 2357 H  H11 . TRS B 2 .   ? -33.30450 36.22570 -14.23118 1.000 65.75463 ? 401 TRS A H11 1 
HETATM 2358 H  H12 . TRS B 2 .   ? -31.97759 35.91420 -13.11367 1.000 65.75463 ? 401 TRS A H12 1 
HETATM 2359 H  H21 . TRS B 2 .   ? -31.01225 34.21061 -14.71809 1.000 61.14918 ? 401 TRS A H21 1 
HETATM 2360 H  H22 . TRS B 2 .   ? -32.37925 34.51729 -15.78758 1.000 61.14918 ? 401 TRS A H22 1 
HETATM 2361 H  H31 . TRS B 2 .   ? -29.82844 36.39351 -13.58064 1.000 68.95824 ? 401 TRS A H31 1 
HETATM 2362 H  H32 . TRS B 2 .   ? -29.17306 36.01682 -15.17285 1.000 68.95824 ? 401 TRS A H32 1 
HETATM 2363 H  HN1 . TRS B 2 .   ? -32.49695 37.99791 -16.24654 1.000 46.95599 ? 401 TRS A HN1 1 
HETATM 2364 H  HN2 . TRS B 2 .   ? -32.23100 36.85671 -17.21862 1.000 46.95599 ? 401 TRS A HN2 1 
HETATM 2365 H  HN3 . TRS B 2 .   ? -31.12364 37.84734 -16.88633 1.000 46.95599 ? 401 TRS A HN3 1 
HETATM 2366 H  HO1 . TRS B 2 .   ? -31.38789 38.14989 -13.28435 1.000 57.61560 ? 401 TRS A HO1 1 
HETATM 2367 H  HO2 . TRS B 2 .   ? -29.67287 34.25110 -16.39033 1.000 45.62520 ? 401 TRS A HO2 1 
HETATM 2368 H  HO3 . TRS B 2 .   ? -29.29812 38.40172 -14.06296 1.000 58.97916 ? 401 TRS A HO3 1 
HETATM 2369 MG MG  . MG  C 3 .   ? -20.68456 28.96856 -14.88444 1.000 37.77429 ? 402 MG  A MG  1 
HETATM 2370 O  O   . HOH D 4 .   ? -34.467   -6.539   -8.463    1.000 27.67249 ? 501 HOH A O   1 
HETATM 2371 O  O   . HOH D 4 .   ? -12.98620 -1.03364 -15.71156 1.000 30.11075 ? 502 HOH A O   1 
HETATM 2372 O  O   . HOH D 4 .   ? -14.48607 17.04711 8.68618   1.000 35.21032 ? 503 HOH A O   1 
HETATM 2373 O  O   . HOH D 4 .   ? -6.68351  15.67687 -3.11657  1.000 31.81548 ? 504 HOH A O   1 
HETATM 2374 O  O   . HOH D 4 .   ? -41.10537 4.58500  -18.14515 1.000 33.65333 ? 505 HOH A O   1 
HETATM 2375 O  O   . HOH D 4 .   ? -9.94642  1.08742  -5.27198  1.000 26.82579 ? 506 HOH A O   1 
HETATM 2376 O  O   . HOH D 4 .   ? -48.070   8.411    0.760     1.000 13.89138 ? 507 HOH A O   1 
HETATM 2377 O  O   . HOH D 4 .   ? -41.39661 -4.08339 5.63860   1.000 28.91997 ? 508 HOH A O   1 
HETATM 2378 O  O   . HOH D 4 .   ? -28.364   35.432   -17.580   1.000 34.55745 ? 509 HOH A O   1 
HETATM 2379 O  O   . HOH D 4 .   ? -43.19574 15.58648 7.82970   1.000 28.00395 ? 510 HOH A O   1 
HETATM 2380 O  O   . HOH D 4 .   ? -14.03934 22.53731 1.57141   1.000 26.28375 ? 511 HOH A O   1 
HETATM 2381 O  O   . HOH D 4 .   ? -17.24386 31.86838 -15.97464 1.000 28.60796 ? 512 HOH A O   1 
HETATM 2382 O  O   . HOH D 4 .   ? -19.19675 20.26825 -16.74953 1.000 21.56466 ? 513 HOH A O   1 
HETATM 2383 O  O   . HOH D 4 .   ? -39.16671 14.65712 -19.66448 1.000 34.50587 ? 514 HOH A O   1 
HETATM 2384 O  O   . HOH D 4 .   ? -37.82536 31.02683 -13.76002 1.000 20.74321 ? 515 HOH A O   1 
HETATM 2385 O  O   . HOH D 4 .   ? -28.52127 27.76921 -17.17675 1.000 22.44985 ? 516 HOH A O   1 
HETATM 2386 O  O   . HOH D 4 .   ? -34.48283 -2.70522 10.49611  1.000 34.89777 ? 517 HOH A O   1 
HETATM 2387 O  O   . HOH D 4 .   ? -24.74170 23.96549 15.30438  1.000 32.12731 ? 518 HOH A O   1 
HETATM 2388 O  O   . HOH D 4 .   ? -37.87641 -0.95615 7.26430   1.000 28.57208 ? 519 HOH A O   1 
HETATM 2389 O  O   . HOH D 4 .   ? -31.10113 24.38077 20.75043  1.000 37.04462 ? 520 HOH A O   1 
HETATM 2390 O  O   . HOH D 4 .   ? -29.94530 28.64775 -2.03234  1.000 32.18157 ? 521 HOH A O   1 
HETATM 2391 O  O   . HOH D 4 .   ? -20.81624 5.63663  19.90222  1.000 25.25833 ? 522 HOH A O   1 
HETATM 2392 O  O   . HOH D 4 .   ? -44.08674 12.04368 -9.79544  1.000 20.85879 ? 523 HOH A O   1 
HETATM 2393 O  O   . HOH D 4 .   ? -16.721   31.577   -5.343    1.000 29.80063 ? 524 HOH A O   1 
HETATM 2394 O  O   . HOH D 4 .   ? -40.39183 -5.91598 -2.72876  1.000 37.58854 ? 525 HOH A O   1 
HETATM 2395 O  O   . HOH D 4 .   ? -18.52568 -1.12167 -6.02685  1.000 30.94954 ? 526 HOH A O   1 
HETATM 2396 O  O   . HOH D 4 .   ? -31.32759 6.17731  -23.90180 1.000 32.95326 ? 527 HOH A O   1 
HETATM 2397 O  O   . HOH D 4 .   ? -27.338   38.126   -15.928   1.000 41.89082 ? 528 HOH A O   1 
HETATM 2398 O  O   . HOH D 4 .   ? -32.47178 17.91546 23.49274  1.000 34.52660 ? 529 HOH A O   1 
HETATM 2399 O  O   . HOH D 4 .   ? -11.56060 12.93551 -14.41446 1.000 27.80122 ? 530 HOH A O   1 
HETATM 2400 O  O   . HOH D 4 .   ? -37.17673 31.11103 -2.62357  1.000 36.14558 ? 531 HOH A O   1 
HETATM 2401 O  O   . HOH D 4 .   ? -18.52065 -3.75853 9.16402   1.000 30.82618 ? 532 HOH A O   1 
HETATM 2402 O  O   . HOH D 4 .   ? -32.141   28.487   -18.045   1.000 28.60778 ? 533 HOH A O   1 
HETATM 2403 O  O   . HOH D 4 .   ? -13.56857 22.08155 -17.53971 1.000 18.48351 ? 534 HOH A O   1 
HETATM 2404 O  O   . HOH D 4 .   ? -30.03547 5.34066  4.58400   1.000 12.35539 ? 535 HOH A O   1 
HETATM 2405 O  O   . HOH D 4 .   ? -11.17182 8.23403  -15.91739 1.000 28.14400 ? 536 HOH A O   1 
HETATM 2406 O  O   . HOH D 4 .   ? -16.69296 -1.96745 0.39722   1.000 29.33411 ? 537 HOH A O   1 
HETATM 2407 O  O   . HOH D 4 .   ? -21.40418 -3.27728 6.65006   1.000 23.10282 ? 538 HOH A O   1 
HETATM 2408 O  O   . HOH D 4 .   ? -34.08918 21.87836 -23.80058 1.000 33.69835 ? 539 HOH A O   1 
HETATM 2409 O  O   . HOH D 4 .   ? -8.89795  8.56265  0.37740   1.000 23.66230 ? 540 HOH A O   1 
HETATM 2410 O  O   . HOH D 4 .   ? -29.71279 25.49428 -18.18874 1.000 19.47344 ? 541 HOH A O   1 
HETATM 2411 O  O   . HOH D 4 .   ? -21.31644 1.46791  2.87296   1.000 15.06733 ? 542 HOH A O   1 
HETATM 2412 O  O   . HOH D 4 .   ? -24.34343 20.89211 21.24046  1.000 38.07467 ? 543 HOH A O   1 
HETATM 2413 O  O   . HOH D 4 .   ? -14.05072 1.59795  -7.44492  1.000 17.27192 ? 544 HOH A O   1 
HETATM 2414 O  O   . HOH D 4 .   ? -23.55828 32.11577 -14.18255 1.000 35.09532 ? 545 HOH A O   1 
HETATM 2415 O  O   . HOH D 4 .   ? -21.71729 20.53507 -17.86096 1.000 23.68491 ? 546 HOH A O   1 
HETATM 2416 O  O   . HOH D 4 .   ? -16.14790 6.78154  -18.45719 1.000 31.70838 ? 547 HOH A O   1 
HETATM 2417 O  O   . HOH D 4 .   ? -45.09967 16.47211 3.17462   1.000 24.88128 ? 548 HOH A O   1 
HETATM 2418 O  O   . HOH D 4 .   ? -42.41331 -0.21965 9.77270   1.000 25.92459 ? 549 HOH A O   1 
HETATM 2419 O  O   . HOH D 4 .   ? -20.15684 7.93459  -5.48544  1.000 11.60048 ? 550 HOH A O   1 
HETATM 2420 O  O   . HOH D 4 .   ? -10.47821 5.87437  2.51602   1.000 28.32398 ? 551 HOH A O   1 
HETATM 2421 O  O   . HOH D 4 .   ? -7.13687  6.47958  0.43922   1.000 26.47294 ? 552 HOH A O   1 
HETATM 2422 O  O   . HOH D 4 .   ? -22.14617 38.35830 -4.52083  0.50  41.57173 ? 553 HOH A O   1 
HETATM 2423 O  O   . HOH D 4 .   ? -35.56085 10.95283 16.27730  1.000 37.16192 ? 554 HOH A O   1 
HETATM 2424 O  O   . HOH D 4 .   ? -20.41221 6.02952  10.32051  1.000 18.43705 ? 555 HOH A O   1 
HETATM 2425 O  O   . HOH D 4 .   ? -41.62338 21.49135 5.08506   1.000 16.75512 ? 556 HOH A O   1 
HETATM 2426 O  O   . HOH D 4 .   ? -22.54822 30.16180 -14.22215 1.000 30.22202 ? 557 HOH A O   1 
HETATM 2427 O  O   . HOH D 4 .   ? -2.54733  5.21939  -7.52056  1.000 40.96570 ? 558 HOH A O   1 
HETATM 2428 O  O   . HOH D 4 .   ? -44.81833 19.81331 -13.06921 1.000 24.66353 ? 559 HOH A O   1 
HETATM 2429 O  O   . HOH D 4 .   ? -42.48484 21.17800 -3.34794  1.000 23.04670 ? 560 HOH A O   1 
HETATM 2430 O  O   . HOH D 4 .   ? -29.41227 11.17992 -15.17424 1.000 9.94380  ? 561 HOH A O   1 
HETATM 2431 O  O   . HOH D 4 .   ? -36.12573 7.43366  -19.03458 1.000 24.33672 ? 562 HOH A O   1 
HETATM 2432 O  O   . HOH D 4 .   ? -40.68001 2.62290  0.92157   1.000 18.99337 ? 563 HOH A O   1 
HETATM 2433 O  O   . HOH D 4 .   ? -15.76428 19.96932 -0.46329  1.000 24.35652 ? 564 HOH A O   1 
HETATM 2434 O  O   . HOH D 4 .   ? -44.40434 11.20947 -4.71147  1.000 13.99310 ? 565 HOH A O   1 
HETATM 2435 O  O   . HOH D 4 .   ? -23.99414 20.60469 -21.32906 1.000 43.01297 ? 566 HOH A O   1 
HETATM 2436 O  O   . HOH D 4 .   ? -22.98441 25.86341 20.93643  1.000 44.09763 ? 567 HOH A O   1 
HETATM 2437 O  O   . HOH D 4 .   ? -30.74313 31.74177 -9.41082  1.000 28.83364 ? 568 HOH A O   1 
HETATM 2438 O  O   . HOH D 4 .   ? -41.50215 9.37801  7.91638   1.000 15.97111 ? 569 HOH A O   1 
HETATM 2439 O  O   . HOH D 4 .   ? -28.60273 -4.72893 3.58609   1.000 26.21104 ? 570 HOH A O   1 
HETATM 2440 O  O   . HOH D 4 .   ? -19.52753 5.94268  -9.49962  1.000 13.52000 ? 571 HOH A O   1 
HETATM 2441 O  O   . HOH D 4 .   ? -31.96427 23.26092 5.63852   1.000 11.82601 ? 572 HOH A O   1 
HETATM 2442 O  O   . HOH D 4 .   ? -26.77479 20.87850 20.98618  1.000 31.04898 ? 573 HOH A O   1 
HETATM 2443 O  O   . HOH D 4 .   ? -42.83922 16.54009 -10.70918 1.000 32.23315 ? 574 HOH A O   1 
HETATM 2444 O  O   . HOH D 4 .   ? -20.23479 31.63700 -13.80824 1.000 31.17746 ? 575 HOH A O   1 
HETATM 2445 O  O   . HOH D 4 .   ? -45.25774 8.42089  2.34374   1.000 26.46777 ? 576 HOH A O   1 
HETATM 2446 O  O   . HOH D 4 .   ? -14.82266 8.72458  4.55103   1.000 26.23737 ? 577 HOH A O   1 
HETATM 2447 O  O   . HOH D 4 .   ? -23.25599 5.62782  -20.98074 1.000 23.04202 ? 578 HOH A O   1 
HETATM 2448 O  O   . HOH D 4 .   ? -22.78707 21.77610 14.93201  1.000 22.55807 ? 579 HOH A O   1 
HETATM 2449 O  O   . HOH D 4 .   ? -12.06259 17.54014 -18.01155 1.000 32.50240 ? 580 HOH A O   1 
HETATM 2450 O  O   . HOH D 4 .   ? -28.49334 1.02271  17.15577  1.000 13.10649 ? 581 HOH A O   1 
HETATM 2451 O  O   . HOH D 4 .   ? -35.55297 22.43788 13.22489  1.000 28.05414 ? 582 HOH A O   1 
HETATM 2452 O  O   . HOH D 4 .   ? -16.76706 2.27454  9.73744   1.000 22.44916 ? 583 HOH A O   1 
HETATM 2453 O  O   . HOH D 4 .   ? -39.02249 19.83777 8.25565   1.000 14.24988 ? 584 HOH A O   1 
HETATM 2454 O  O   . HOH D 4 .   ? -35.46250 -1.23786 -15.81512 1.000 20.49054 ? 585 HOH A O   1 
HETATM 2455 O  O   . HOH D 4 .   ? -26.69168 25.30090 -18.11017 1.000 24.08790 ? 586 HOH A O   1 
HETATM 2456 O  O   . HOH D 4 .   ? -14.75713 10.55133 16.26972  1.000 27.22960 ? 587 HOH A O   1 
HETATM 2457 O  O   . HOH D 4 .   ? -14.00683 1.30200  9.54250   1.000 34.04290 ? 588 HOH A O   1 
HETATM 2458 O  O   . HOH D 4 .   ? -21.65559 27.40168 -13.66503 1.000 18.76176 ? 589 HOH A O   1 
HETATM 2459 O  O   . HOH D 4 .   ? -32.00576 0.00928  10.30557  1.000 20.59917 ? 590 HOH A O   1 
HETATM 2460 O  O   . HOH D 4 .   ? -49.78977 3.34561  -7.20641  1.000 34.34531 ? 591 HOH A O   1 
HETATM 2461 O  O   . HOH D 4 .   ? -17.77635 18.01200 -17.04416 1.000 23.09710 ? 592 HOH A O   1 
HETATM 2462 O  O   . HOH D 4 .   ? -20.77077 22.36096 17.58866  1.000 28.63108 ? 593 HOH A O   1 
HETATM 2463 O  O   . HOH D 4 .   ? -17.09001 19.29896 16.93261  1.000 23.19478 ? 594 HOH A O   1 
HETATM 2464 O  O   . HOH D 4 .   ? -22.18664 18.31803 -16.21347 1.000 15.02575 ? 595 HOH A O   1 
HETATM 2465 O  O   . HOH D 4 .   ? -11.30026 1.07419  -15.39188 1.000 22.31169 ? 596 HOH A O   1 
HETATM 2466 O  O   . HOH D 4 .   ? -44.65595 -5.05356 0.22287   1.000 17.52936 ? 597 HOH A O   1 
HETATM 2467 O  O   . HOH D 4 .   ? -34.99068 0.16191  -19.30556 1.000 22.22028 ? 598 HOH A O   1 
HETATM 2468 O  O   . HOH D 4 .   ? -32.39613 -1.50594 3.76099   1.000 14.94373 ? 599 HOH A O   1 
HETATM 2469 O  O   . HOH D 4 .   ? -35.19622 22.30089 7.30657   1.000 16.22059 ? 600 HOH A O   1 
HETATM 2470 O  O   . HOH D 4 .   ? -42.35641 3.02559  -0.85192  1.000 21.07219 ? 601 HOH A O   1 
HETATM 2471 O  O   . HOH D 4 .   ? -32.34347 29.76429 0.22805   1.000 24.72588 ? 602 HOH A O   1 
HETATM 2472 O  O   . HOH D 4 .   ? -45.33489 28.51529 0.13143   1.000 13.64159 ? 603 HOH A O   1 
HETATM 2473 O  O   . HOH D 4 .   ? -46.026   23.710   -12.002   1.000 23.67989 ? 604 HOH A O   1 
HETATM 2474 O  O   . HOH D 4 .   ? -43.63083 12.02838 -14.58698 1.000 27.21782 ? 605 HOH A O   1 
HETATM 2475 O  O   . HOH D 4 .   ? -47.842   18.730   12.399    1.000 33.44880 ? 606 HOH A O   1 
HETATM 2476 O  O   . HOH D 4 .   ? -16.165   25.574   -18.738   1.000 18.65143 ? 607 HOH A O   1 
HETATM 2477 O  O   . HOH D 4 .   ? -31.51785 2.39585  -1.95275  1.000 12.14427 ? 608 HOH A O   1 
HETATM 2478 O  O   . HOH D 4 .   ? -35.02347 5.40880  -19.91166 1.000 24.16145 ? 609 HOH A O   1 
HETATM 2479 O  O   . HOH D 4 .   ? -10.82065 0.62369  -12.41896 1.000 36.21048 ? 610 HOH A O   1 
HETATM 2480 O  O   . HOH D 4 .   ? -37.97816 23.86752 6.67073   1.000 24.31525 ? 611 HOH A O   1 
HETATM 2481 O  O   . HOH D 4 .   ? -13.67939 31.16827 -12.77838 1.000 34.32704 ? 612 HOH A O   1 
HETATM 2482 O  O   . HOH D 4 .   ? -42.93975 12.56264 10.79539  1.000 23.00049 ? 613 HOH A O   1 
HETATM 2483 O  O   . HOH D 4 .   ? -35.66845 21.03045 16.12299  1.000 17.38476 ? 614 HOH A O   1 
HETATM 2484 O  O   . HOH D 4 .   ? -24.83971 16.90192 -19.05744 1.000 23.92625 ? 615 HOH A O   1 
HETATM 2485 O  O   . HOH D 4 .   ? -2.98624  16.33210 -9.22531  1.000 38.14035 ? 616 HOH A O   1 
HETATM 2486 O  O   . HOH D 4 .   ? -31.67044 1.77604  -8.98301  1.000 24.56736 ? 617 HOH A O   1 
HETATM 2487 O  O   . HOH D 4 .   ? -17.34561 27.06501 -20.92995 1.000 31.34519 ? 618 HOH A O   1 
HETATM 2488 O  O   . HOH D 4 .   ? -21.53274 21.35199 12.41464  1.000 22.71141 ? 619 HOH A O   1 
HETATM 2489 O  O   . HOH D 4 .   ? -42.79316 -1.33665 2.58592   1.000 20.90889 ? 620 HOH A O   1 
HETATM 2490 O  O   . HOH D 4 .   ? -36.806   27.739   11.306    1.000 31.53369 ? 621 HOH A O   1 
HETATM 2491 O  O   . HOH D 4 .   ? -33.96286 -7.13023 -0.88007  1.000 26.00130 ? 622 HOH A O   1 
HETATM 2492 O  O   . HOH D 4 .   ? -41.82210 26.21375 -8.84363  1.000 14.15235 ? 623 HOH A O   1 
HETATM 2493 O  O   . HOH D 4 .   ? -23.80577 11.24214 -9.44711  1.000 12.81357 ? 624 HOH A O   1 
HETATM 2494 O  O   . HOH D 4 .   ? -42.69593 18.42758 -12.17740 1.000 20.92002 ? 625 HOH A O   1 
HETATM 2495 O  O   . HOH D 4 .   ? -17.61108 21.57477 10.00011  1.000 17.85116 ? 626 HOH A O   1 
HETATM 2496 O  O   . HOH D 4 .   ? -19.61958 15.80914 18.92687  1.000 27.91445 ? 627 HOH A O   1 
HETATM 2497 O  O   . HOH D 4 .   ? -15.39821 -0.52320 -12.09400 1.000 24.35978 ? 628 HOH A O   1 
HETATM 2498 O  O   . HOH D 4 .   ? -38.35174 10.63073 -17.79031 1.000 22.14950 ? 629 HOH A O   1 
HETATM 2499 O  O   . HOH D 4 .   ? -43.99252 14.13391 5.61847   1.000 20.70609 ? 630 HOH A O   1 
HETATM 2500 O  O   . HOH D 4 .   ? -33.04939 6.95656  -21.30886 1.000 25.58255 ? 631 HOH A O   1 
HETATM 2501 O  O   . HOH D 4 .   ? -23.02517 0.63286  11.43709  1.000 24.22774 ? 632 HOH A O   1 
HETATM 2502 O  O   . HOH D 4 .   ? -27.39296 -4.31174 10.93974  1.000 30.72060 ? 633 HOH A O   1 
HETATM 2503 O  O   . HOH D 4 .   ? -13.73949 14.09605 -15.49918 1.000 22.91184 ? 634 HOH A O   1 
HETATM 2504 O  O   . HOH D 4 .   ? -33.33475 11.57226 -9.43060  1.000 8.89909  ? 635 HOH A O   1 
HETATM 2505 O  O   . HOH D 4 .   ? -28.20943 23.10051 -18.03637 1.000 16.76537 ? 636 HOH A O   1 
HETATM 2506 O  O   . HOH D 4 .   ? -38.18765 23.52603 10.55805  1.000 20.04377 ? 637 HOH A O   1 
HETATM 2507 O  O   . HOH D 4 .   ? -40.33521 -1.03042 -6.90505  1.000 25.11098 ? 638 HOH A O   1 
HETATM 2508 O  O   . HOH D 4 .   ? -2.00308  15.18744 -3.83404  1.000 36.44557 ? 639 HOH A O   1 
HETATM 2509 O  O   . HOH D 4 .   ? -35.52948 10.50913 -10.57458 1.000 16.68460 ? 640 HOH A O   1 
HETATM 2510 O  O   . HOH D 4 .   ? -23.581   -3.785   -10.409   1.000 27.97741 ? 641 HOH A O   1 
HETATM 2511 O  O   . HOH D 4 .   ? -47.40106 8.49090  -4.09311  1.000 30.34123 ? 642 HOH A O   1 
HETATM 2512 O  O   . HOH D 4 .   ? -43.54126 17.96937 -6.13477  1.000 18.38891 ? 643 HOH A O   1 
HETATM 2513 O  O   . HOH D 4 .   ? -29.76745 10.05736 -22.44464 1.000 28.57522 ? 644 HOH A O   1 
HETATM 2514 O  O   . HOH D 4 .   ? -7.91437  13.98341 -13.56783 1.000 29.63171 ? 645 HOH A O   1 
HETATM 2515 O  O   . HOH D 4 .   ? -40.48403 -0.59336 13.33706  1.000 33.16566 ? 646 HOH A O   1 
HETATM 2516 O  O   . HOH D 4 .   ? -31.96814 33.31305 -12.51853 1.000 39.97660 ? 647 HOH A O   1 
HETATM 2517 O  O   . HOH D 4 .   ? -15.98203 9.21365  2.17285   1.000 13.64882 ? 648 HOH A O   1 
HETATM 2518 O  O   . HOH D 4 .   ? -7.28663  6.96382  -10.66474 1.000 21.78818 ? 649 HOH A O   1 
HETATM 2519 O  O   . HOH D 4 .   ? -38.38157 1.68546  6.80632   1.000 16.01635 ? 650 HOH A O   1 
HETATM 2520 O  O   . HOH D 4 .   ? -46.27141 24.69356 -3.95035  1.000 24.14690 ? 651 HOH A O   1 
HETATM 2521 O  O   . HOH D 4 .   ? -40.23015 30.92381 -13.91947 1.000 28.47361 ? 652 HOH A O   1 
HETATM 2522 O  O   . HOH D 4 .   ? -48.06264 5.91984  -10.88914 1.000 32.11298 ? 653 HOH A O   1 
HETATM 2523 O  O   . HOH D 4 .   ? -45.63786 19.34772 -16.26978 1.000 21.11310 ? 654 HOH A O   1 
HETATM 2524 O  O   . HOH D 4 .   ? -16.662   34.938   -5.440    1.000 28.05168 ? 655 HOH A O   1 
HETATM 2525 O  O   . HOH D 4 .   ? -28.99850 1.80743  -8.83556  1.000 25.56638 ? 656 HOH A O   1 
HETATM 2526 O  O   . HOH D 4 .   ? -18.34508 3.58784  -17.23044 1.000 24.94747 ? 657 HOH A O   1 
HETATM 2527 O  O   . HOH D 4 .   ? -36.04767 27.17260 7.32770   1.000 31.64139 ? 658 HOH A O   1 
HETATM 2528 O  O   . HOH D 4 .   ? -39.45308 17.77342 6.69813   1.000 17.56862 ? 659 HOH A O   1 
HETATM 2529 O  O   . HOH D 4 .   ? -42.59083 1.94826  -11.88520 1.000 33.05297 ? 660 HOH A O   1 
HETATM 2530 O  O   . HOH D 4 .   ? -17.998   22.502   -18.078   1.000 25.35890 ? 661 HOH A O   1 
HETATM 2531 O  O   . HOH D 4 .   ? -43.34982 5.39941  2.75052   1.000 16.55164 ? 662 HOH A O   1 
HETATM 2532 O  O   . HOH D 4 .   ? -46.70139 19.47919 1.53222   1.000 36.08080 ? 663 HOH A O   1 
HETATM 2533 O  O   . HOH D 4 .   ? -12.76989 0.06654  -10.26388 1.000 29.00194 ? 664 HOH A O   1 
HETATM 2534 O  O   . HOH D 4 .   ? -44.00072 1.87753  -5.24163  1.000 33.00422 ? 665 HOH A O   1 
HETATM 2535 O  O   . HOH D 4 .   ? -26.57142 -2.66657 14.40444  1.000 23.16865 ? 666 HOH A O   1 
HETATM 2536 O  O   . HOH D 4 .   ? -25.71162 29.46021 1.29626   1.000 26.21394 ? 667 HOH A O   1 
HETATM 2537 O  O   . HOH D 4 .   ? -17.02815 27.78160 7.09318   1.000 26.62195 ? 668 HOH A O   1 
HETATM 2538 O  O   . HOH D 4 .   ? -43.21457 12.98775 13.93127  1.000 26.99192 ? 669 HOH A O   1 
HETATM 2539 O  O   . HOH D 4 .   ? -45.53870 21.85017 -7.28878  1.000 28.24278 ? 670 HOH A O   1 
HETATM 2540 O  O   . HOH D 4 .   ? -43.72317 2.38941  6.28586   1.000 37.31889 ? 671 HOH A O   1 
HETATM 2541 O  O   . HOH D 4 .   ? -44.516   17.139   -8.550    1.000 23.35588 ? 672 HOH A O   1 
HETATM 2542 O  O   . HOH D 4 .   ? -18.458   24.477   -23.805   1.000 35.01939 ? 673 HOH A O   1 
HETATM 2543 O  O   . HOH D 4 .   ? -21.88021 4.65599  15.02062  1.000 24.03807 ? 674 HOH A O   1 
HETATM 2544 O  O   . HOH D 4 .   ? -39.60904 13.11702 -17.74664 1.000 22.92624 ? 675 HOH A O   1 
HETATM 2545 O  O   . HOH D 4 .   ? -27.94618 26.44485 0.14022   1.000 21.75991 ? 676 HOH A O   1 
HETATM 2546 O  O   . HOH D 4 .   ? -19.03501 9.33345  -3.36411  1.000 13.67532 ? 677 HOH A O   1 
HETATM 2547 O  O   . HOH D 4 .   ? -21.59040 3.06208  0.42672   1.000 14.42777 ? 678 HOH A O   1 
HETATM 2548 O  O   . HOH D 4 .   ? -5.735    17.024   -17.644   1.000 36.26517 ? 679 HOH A O   1 
HETATM 2549 O  O   . HOH D 4 .   ? -42.08387 -3.95021 -3.35567  1.000 33.26218 ? 680 HOH A O   1 
HETATM 2550 O  O   . HOH D 4 .   ? -27.40456 21.81277 -20.26654 1.000 21.53923 ? 681 HOH A O   1 
HETATM 2551 O  O   . HOH D 4 .   ? -33.366   26.219   13.534    1.000 25.53453 ? 682 HOH A O   1 
HETATM 2552 O  O   . HOH D 4 .   ? -35.40418 12.87089 22.49465  1.000 39.54488 ? 683 HOH A O   1 
HETATM 2553 O  O   . HOH D 4 .   ? -27.33680 14.58928 -21.59366 1.000 32.41462 ? 684 HOH A O   1 
HETATM 2554 O  O   . HOH D 4 .   ? -32.52639 30.82419 -3.67867  1.000 19.58012 ? 685 HOH A O   1 
HETATM 2555 O  O   . HOH D 4 .   ? -25.14696 11.41332 22.25054  1.000 22.21829 ? 686 HOH A O   1 
HETATM 2556 O  O   . HOH D 4 .   ? -47.641   16.008   12.630    1.000 32.15338 ? 687 HOH A O   1 
HETATM 2557 O  O   . HOH D 4 .   ? -6.11932  14.03808 -11.83060 1.000 29.02157 ? 688 HOH A O   1 
HETATM 2558 O  O   . HOH D 4 .   ? -35.72330 -4.98930 4.71220   1.000 23.60914 ? 689 HOH A O   1 
HETATM 2559 O  O   . HOH D 4 .   ? -10.57556 16.65776 5.26815   1.000 17.96602 ? 690 HOH A O   1 
HETATM 2560 O  O   . HOH D 4 .   ? -10.91077 0.68003  4.63367   1.000 25.43829 ? 691 HOH A O   1 
HETATM 2561 O  O   . HOH D 4 .   ? -33.14869 -3.67301 5.30809   1.000 34.63115 ? 692 HOH A O   1 
HETATM 2562 O  O   . HOH D 4 .   ? -37.00420 20.01508 19.37232  1.000 29.40134 ? 693 HOH A O   1 
HETATM 2563 O  O   . HOH D 4 .   ? -43.15889 0.89650  -2.66092  1.000 36.25866 ? 694 HOH A O   1 
HETATM 2564 O  O   . HOH D 4 .   ? -20.02680 29.39007 -2.20782  1.000 17.66900 ? 695 HOH A O   1 
HETATM 2565 O  O   . HOH D 4 .   ? -19.21381 7.22754  18.92697  1.000 27.24638 ? 696 HOH A O   1 
HETATM 2566 O  O   . HOH D 4 .   ? -29.58127 -1.22501 9.60099   1.000 15.02202 ? 697 HOH A O   1 
HETATM 2567 O  O   . HOH D 4 .   ? -25.57339 -4.32087 7.86338   1.000 30.46405 ? 698 HOH A O   1 
HETATM 2568 O  O   . HOH D 4 .   ? -24.09165 7.44992  -22.58495 1.000 34.77650 ? 699 HOH A O   1 
HETATM 2569 O  O   . HOH D 4 .   ? -12.92186 -3.58644 7.41325   1.000 38.40562 ? 700 HOH A O   1 
HETATM 2570 O  O   . HOH D 4 .   ? -18.82667 8.00354  15.80002  1.000 17.45787 ? 701 HOH A O   1 
HETATM 2571 O  O   . HOH D 4 .   ? -7.43875  21.73710 -14.96862 1.000 20.20236 ? 702 HOH A O   1 
HETATM 2572 O  O   . HOH D 4 .   ? -34.265   25.363   15.695    1.000 29.01575 ? 703 HOH A O   1 
HETATM 2573 O  O   . HOH D 4 .   ? -21.27588 7.32216  -19.51476 1.000 15.86113 ? 704 HOH A O   1 
HETATM 2574 O  O   . HOH D 4 .   ? -35.126   -1.587   -8.456    1.000 19.88897 ? 705 HOH A O   1 
HETATM 2575 O  O   . HOH D 4 .   ? -34.35945 9.57584  -22.07316 1.000 31.63910 ? 706 HOH A O   1 
HETATM 2576 O  O   . HOH D 4 .   ? -28.307   19.665   28.810    1.000 25.65041 ? 707 HOH A O   1 
HETATM 2577 O  O   . HOH D 4 .   ? -32.01344 -3.90314 7.27942   1.000 41.25535 ? 708 HOH A O   1 
HETATM 2578 O  O   . HOH D 4 .   ? -16.89681 10.46998 -17.46059 1.000 21.48541 ? 709 HOH A O   1 
HETATM 2579 O  O   . HOH D 4 .   ? -28.31603 12.83214 24.02461  1.000 40.46509 ? 710 HOH A O   1 
HETATM 2580 O  O   . HOH D 4 .   ? -39.08416 -5.61141 4.66897   1.000 29.27869 ? 711 HOH A O   1 
HETATM 2581 O  O   . HOH D 4 .   ? -26.75446 -1.33071 -6.99920  1.000 31.42762 ? 712 HOH A O   1 
HETATM 2582 O  O   . HOH D 4 .   ? -44.96247 21.55223 -4.59591  1.000 26.59323 ? 713 HOH A O   1 
HETATM 2583 O  O   . HOH D 4 .   ? -5.85982  7.12238  -13.01673 1.000 34.70347 ? 714 HOH A O   1 
HETATM 2584 O  O   . HOH D 4 .   ? -39.976   20.878   17.252    1.000 37.28493 ? 715 HOH A O   1 
HETATM 2585 O  O   . HOH D 4 .   ? -43.73206 10.24714 9.42244   1.000 21.34767 ? 716 HOH A O   1 
HETATM 2586 O  O   . HOH D 4 .   ? -44.68851 -2.47720 3.53331   1.000 29.75882 ? 717 HOH A O   1 
HETATM 2587 O  O   . HOH D 4 .   ? -12.47134 9.71028  15.44583  1.000 32.85281 ? 718 HOH A O   1 
HETATM 2588 O  O   . HOH D 4 .   ? -31.26603 -6.51931 -1.46701  1.000 24.39974 ? 719 HOH A O   1 
HETATM 2589 O  O   . HOH D 4 .   ? -14.594   33.171   -5.754    1.000 25.58872 ? 720 HOH A O   1 
HETATM 2590 O  O   . HOH D 4 .   ? -40.91419 1.73806  5.62198   1.000 23.92779 ? 721 HOH A O   1 
HETATM 2591 O  O   . HOH D 4 .   ? -10.530   13.447   5.587     1.000 35.97096 ? 722 HOH A O   1 
HETATM 2592 O  O   . HOH D 4 .   ? -44.43232 21.80359 5.44903   1.000 34.93274 ? 723 HOH A O   1 
HETATM 2593 O  O   . HOH D 4 .   ? -16.140   15.764   21.564    1.000 31.57404 ? 724 HOH A O   1 
HETATM 2594 O  O   . HOH D 4 .   ? -9.28204  -0.54483 3.41159   1.000 39.12233 ? 725 HOH A O   1 
HETATM 2595 O  O   . HOH D 4 .   ? -15.42780 12.96181 -16.95955 1.000 30.70132 ? 726 HOH A O   1 
HETATM 2596 O  O   . HOH D 4 .   ? -16.34335 14.48752 -19.10098 1.000 34.85861 ? 727 HOH A O   1 
HETATM 2597 O  O   . HOH D 4 .   ? -22.95760 -3.34180 8.73164   1.000 23.10043 ? 728 HOH A O   1 
HETATM 2598 O  O   . HOH D 4 .   ? -47.98561 18.64128 -1.68422  1.000 32.30629 ? 729 HOH A O   1 
HETATM 2599 O  O   . HOH D 4 .   ? -48.408   2.317    7.646     1.000 37.44832 ? 730 HOH A O   1 
HETATM 2600 O  O   . HOH D 4 .   ? -28.044   23.358   27.540    1.000 36.69819 ? 731 HOH A O   1 
HETATM 2601 O  O   . HOH D 4 .   ? -41.67577 1.26734  3.18024   1.000 20.99418 ? 732 HOH A O   1 
HETATM 2602 O  O   . HOH D 4 .   ? -23.373   0.277    14.664    1.000 24.37733 ? 733 HOH A O   1 
HETATM 2603 O  O   . HOH D 4 .   ? -26.503   -3.126   -9.012    1.000 33.83475 ? 734 HOH A O   1 
HETATM 2604 O  O   . HOH D 4 .   ? -5.76087  4.53376  -9.56514  1.000 30.09999 ? 735 HOH A O   1 
HETATM 2605 O  O   . HOH D 4 .   ? -6.84917  1.43483  -6.66408  1.000 41.07645 ? 736 HOH A O   1 
HETATM 2606 O  O   . HOH D 4 .   ? -44.29235 0.00000  7.37498   0.50  41.42505 ? 737 HOH A O   1 
HETATM 2607 O  O   . HOH D 4 .   ? -35.84473 19.08128 21.46278  1.000 41.43711 ? 738 HOH A O   1 
HETATM 2608 O  O   . HOH D 4 .   ? -22.21024 -1.99169 11.27653  1.000 29.12418 ? 739 HOH A O   1 
HETATM 2609 O  O   . HOH D 4 .   ? -40.27212 22.15286 7.22503   1.000 18.61369 ? 740 HOH A O   1 
HETATM 2610 O  O   . HOH D 4 .   ? -36.650   40.909   -7.690    1.000 39.33585 ? 741 HOH A O   1 
HETATM 2611 O  O   . HOH D 4 .   ? -47.30400 12.17208 13.05351  1.000 36.86425 ? 742 HOH A O   1 
HETATM 2612 O  O   . HOH D 4 .   ? -28.966   15.381   26.028    1.000 31.46986 ? 743 HOH A O   1 
HETATM 2613 O  O   . HOH D 4 .   ? -37.55046 22.60558 14.54340  1.000 31.56402 ? 744 HOH A O   1 
HETATM 2614 O  O   . HOH D 4 .   ? -20.62083 2.07632  12.19664  1.000 25.59879 ? 745 HOH A O   1 
HETATM 2615 O  O   . HOH D 4 .   ? -28.13600 28.61955 -19.85300 1.000 36.69308 ? 746 HOH A O   1 
HETATM 2616 O  O   . HOH D 4 .   ? -44.29235 0.00000  0.30508   0.50  36.98402 ? 747 HOH A O   1 
HETATM 2617 O  O   . HOH D 4 .   ? -24.44274 -3.87159 13.49174  1.000 32.22605 ? 748 HOH A O   1 
HETATM 2618 O  O   . HOH D 4 .   ? -4.711    19.509   -18.221   1.000 25.06131 ? 749 HOH A O   1 
HETATM 2619 O  O   . HOH D 4 .   ? -26.539   17.512   28.338    1.000 32.70298 ? 750 HOH A O   1 
HETATM 2620 O  O   . HOH D 4 .   ? -18.602   18.297   23.447    1.000 50.12766 ? 751 HOH A O   1 
HETATM 2621 O  O   . HOH D 4 .   ? -16.95821 3.94250  11.25579  1.000 39.70131 ? 752 HOH A O   1 
HETATM 2622 O  O   . HOH D 4 .   ? -45.98936 11.00842 8.17297   1.000 38.35879 ? 753 HOH A O   1 
HETATM 2623 O  O   . HOH D 4 .   ? -19.06025 4.70176  12.25380  1.000 27.47587 ? 754 HOH A O   1 
HETATM 2624 O  O   . HOH D 4 .   ? -47.25579 23.97958 -7.91806  1.000 36.65200 ? 755 HOH A O   1 
HETATM 2625 O  O   . HOH D 4 .   ? -42.10079 12.77580 -16.90116 1.000 30.62146 ? 756 HOH A O   1 
HETATM 2626 O  O   . HOH D 4 .   ? -19.53769 -2.15794 11.16394  1.000 30.31146 ? 757 HOH A O   1 
HETATM 2627 O  O   . HOH D 4 .   ? -29.12478 25.82619 -21.04017 1.000 33.48836 ? 758 HOH A O   1 
HETATM 2628 O  O   . HOH D 4 .   ? -18.32339 0.54162  11.50929  1.000 44.16025 ? 759 HOH A O   1 
HETATM 2629 O  O   . HOH D 4 .   ? -16.44106 8.26877  16.34842  1.000 25.71833 ? 760 HOH A O   1 
HETATM 2630 O  O   . HOH D 4 .   ? -41.77219 18.74771 5.72239   1.000 23.42179 ? 761 HOH A O   1 
# 
