data_9BYI
# 
_entry.id   9BYI 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BYI         pdb_00009byi 10.2210/pdb9byi/pdb 
WWPDB D_1000284297 ?            ?                   
EMDB  EMD-45034    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-26 ? 
2 'EM metadata'     1 0 2025-02-26 ? 
3 'Half map'        1 0 2025-02-26 1 
4 'Half map'        1 0 2025-02-26 2 
5 Image             1 0 2025-02-26 ? 
6 'Primary map'     1 0 2025-02-26 ? 
7 'Structure model' 1 1 2025-03-12 ? 
8 'Structure model' 1 2 2025-05-21 ? 
9 'EM metadata'     1 1 2025-05-21 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 'Half map'        repository 'Initial release' ? ? 
4 4 'Half map'        repository 'Initial release' ? ? 
5 5 Image             repository 'Initial release' ? ? 
6 6 'Primary map'     repository 'Initial release' ? ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 7 'Structure model' 'Data collection'      
2 7 'Structure model' 'Database references'  
3 8 'Structure model' 'Data collection'      
4 9 'EM metadata'     'Data processing'      
5 9 'EM metadata'     'Experimental summary' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 7 'Structure model' citation        
2 7 'Structure model' citation_author 
3 7 'Structure model' em_admin        
4 8 'Structure model' em_admin        
5 8 'Structure model' em_software     
6 9 'EM metadata'     em_admin        
7 9 'EM metadata'     em_software     
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  7 'Structure model' '_citation.country'                 
2  7 'Structure model' '_citation.journal_abbrev'          
3  7 'Structure model' '_citation.journal_id_CSD'          
4  7 'Structure model' '_citation.journal_id_ISSN'         
5  7 'Structure model' '_citation.pdbx_database_id_DOI'    
6  7 'Structure model' '_citation.pdbx_database_id_PubMed' 
7  7 'Structure model' '_citation.title'                   
8  7 'Structure model' '_citation.year'                    
9  7 'Structure model' '_em_admin.last_update'             
10 8 'Structure model' '_em_admin.last_update'             
11 8 'Structure model' '_em_software.name'                 
12 9 'EM metadata'     '_em_admin.last_update'             
13 9 'EM metadata'     '_em_software.name'                 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BYI 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-23 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB  .                                                 9BSN      unspecified            
EMDB .                                                 EMD-44870 'other EM volume'      
EMDB 'Structure of human K2P13.1 (THIK1) in detergent' EMD-45034 'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              daniel.minor@ucsf.edu 
_pdbx_contact_author.name_first         Daniel 
_pdbx_contact_author.name_last          Minor 
_pdbx_contact_author.name_mi            L. 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-5998-4214 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Roy-Chowdhury, S.' 1 0000-0001-7128-7668 
'Minor, D.L.'       2 0000-0002-5998-4214 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Nat.Struct.Mol.Biol. 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1545-9985 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Structure of the human K 2P 13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41594-024-01476-3 
_citation.pdbx_database_id_PubMed   40011746 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Roy-Chowdhury, S.'  1 ?                   
primary 'Jang, S.'           2 ?                   
primary 'Abderemane-Ali, F.' 3 0000-0002-7097-1684 
primary 'Naughton, F.'       4 0000-0003-0162-1346 
primary 'Grabe, M.'          5 0000-0003-3509-5997 
primary 'Minor Jr., D.L.'    6 0000-0002-5998-4214 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Potassium channel subfamily K member 13' 39373.574 2  ? 'N59Q, N65Q' 
'K2P13.1 residues 1-350 with SNS linker followed by 3C protease site' ? 
2 non-polymer syn HEXANE                                    86.175    4  ? ?            ? ? 
3 non-polymer syn DODECANE                                  170.335   8  ? ?            ? ? 
4 non-polymer syn N-OCTANE                                  114.229   12 ? ?            ? ? 
5 non-polymer syn HEXADECANE                                226.441   2  ? ?            ? ? 
6 non-polymer syn 'LINOLEIC ACID'                           280.445   2  ? ?            ? ? 
7 non-polymer syn 'POTASSIUM ION'                           39.098    3  ? ?            ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Tandem pore domain halothane-inhibited potassium channel 1,THIK-1' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MAGRGFSWGPGHLNEDNARFLLLAALIVLYLLGGAAVFSALELAHERQAKQRWEERLAQFSRGHQLSRDELRGFLRHYEE
ATRAGIRVDNVRPRWDFTGAFYFVGTVVSTIGFGMTTPATVGGKIFLIFYGLVGCSSTILFFNLFLERLITIIAYIMKSC
HQRQLRRRGALPQESLKDAGQCEVDSLAGWKPSVYYVMLILCTASILISCCASAMYTPIEGWSYFDSLYFCFVAFSTIGF
GDLVSSQNAHYESQGLYRFANFVFILMGVCCIYSLFNVISILIKQSLNWILRKMDSGCCPQCQRGLLRSRRNVVMPGSVR
NRCNISIETDGVAESDTDGRRLSGEMISMK
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MAGRGFSWGPGHLNEDNARFLLLAALIVLYLLGGAAVFSALELAHERQAKQRWEERLAQFSRGHQLSRDELRGFLRHYEE
ATRAGIRVDNVRPRWDFTGAFYFVGTVVSTIGFGMTTPATVGGKIFLIFYGLVGCSSTILFFNLFLERLITIIAYIMKSC
HQRQLRRRGALPQESLKDAGQCEVDSLAGWKPSVYYVMLILCTASILISCCASAMYTPIEGWSYFDSLYFCFVAFSTIGF
GDLVSSQNAHYESQGLYRFANFVFILMGVCCIYSLFNVISILIKQSLNWILRKMDSGCCPQCQRGLLRSRRNVVMPGSVR
NRCNISIETDGVAESDTDGRRLSGEMISMK
;
_entity_poly.pdbx_strand_id                 U,A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 HEXANE          HEX 
3 DODECANE        D12 
4 N-OCTANE        OCT 
5 HEXADECANE      R16 
6 'LINOLEIC ACID' EIC 
7 'POTASSIUM ION' K   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   GLY n 
1 4   ARG n 
1 5   GLY n 
1 6   PHE n 
1 7   SER n 
1 8   TRP n 
1 9   GLY n 
1 10  PRO n 
1 11  GLY n 
1 12  HIS n 
1 13  LEU n 
1 14  ASN n 
1 15  GLU n 
1 16  ASP n 
1 17  ASN n 
1 18  ALA n 
1 19  ARG n 
1 20  PHE n 
1 21  LEU n 
1 22  LEU n 
1 23  LEU n 
1 24  ALA n 
1 25  ALA n 
1 26  LEU n 
1 27  ILE n 
1 28  VAL n 
1 29  LEU n 
1 30  TYR n 
1 31  LEU n 
1 32  LEU n 
1 33  GLY n 
1 34  GLY n 
1 35  ALA n 
1 36  ALA n 
1 37  VAL n 
1 38  PHE n 
1 39  SER n 
1 40  ALA n 
1 41  LEU n 
1 42  GLU n 
1 43  LEU n 
1 44  ALA n 
1 45  HIS n 
1 46  GLU n 
1 47  ARG n 
1 48  GLN n 
1 49  ALA n 
1 50  LYS n 
1 51  GLN n 
1 52  ARG n 
1 53  TRP n 
1 54  GLU n 
1 55  GLU n 
1 56  ARG n 
1 57  LEU n 
1 58  ALA n 
1 59  GLN n 
1 60  PHE n 
1 61  SER n 
1 62  ARG n 
1 63  GLY n 
1 64  HIS n 
1 65  GLN n 
1 66  LEU n 
1 67  SER n 
1 68  ARG n 
1 69  ASP n 
1 70  GLU n 
1 71  LEU n 
1 72  ARG n 
1 73  GLY n 
1 74  PHE n 
1 75  LEU n 
1 76  ARG n 
1 77  HIS n 
1 78  TYR n 
1 79  GLU n 
1 80  GLU n 
1 81  ALA n 
1 82  THR n 
1 83  ARG n 
1 84  ALA n 
1 85  GLY n 
1 86  ILE n 
1 87  ARG n 
1 88  VAL n 
1 89  ASP n 
1 90  ASN n 
1 91  VAL n 
1 92  ARG n 
1 93  PRO n 
1 94  ARG n 
1 95  TRP n 
1 96  ASP n 
1 97  PHE n 
1 98  THR n 
1 99  GLY n 
1 100 ALA n 
1 101 PHE n 
1 102 TYR n 
1 103 PHE n 
1 104 VAL n 
1 105 GLY n 
1 106 THR n 
1 107 VAL n 
1 108 VAL n 
1 109 SER n 
1 110 THR n 
1 111 ILE n 
1 112 GLY n 
1 113 PHE n 
1 114 GLY n 
1 115 MET n 
1 116 THR n 
1 117 THR n 
1 118 PRO n 
1 119 ALA n 
1 120 THR n 
1 121 VAL n 
1 122 GLY n 
1 123 GLY n 
1 124 LYS n 
1 125 ILE n 
1 126 PHE n 
1 127 LEU n 
1 128 ILE n 
1 129 PHE n 
1 130 TYR n 
1 131 GLY n 
1 132 LEU n 
1 133 VAL n 
1 134 GLY n 
1 135 CYS n 
1 136 SER n 
1 137 SER n 
1 138 THR n 
1 139 ILE n 
1 140 LEU n 
1 141 PHE n 
1 142 PHE n 
1 143 ASN n 
1 144 LEU n 
1 145 PHE n 
1 146 LEU n 
1 147 GLU n 
1 148 ARG n 
1 149 LEU n 
1 150 ILE n 
1 151 THR n 
1 152 ILE n 
1 153 ILE n 
1 154 ALA n 
1 155 TYR n 
1 156 ILE n 
1 157 MET n 
1 158 LYS n 
1 159 SER n 
1 160 CYS n 
1 161 HIS n 
1 162 GLN n 
1 163 ARG n 
1 164 GLN n 
1 165 LEU n 
1 166 ARG n 
1 167 ARG n 
1 168 ARG n 
1 169 GLY n 
1 170 ALA n 
1 171 LEU n 
1 172 PRO n 
1 173 GLN n 
1 174 GLU n 
1 175 SER n 
1 176 LEU n 
1 177 LYS n 
1 178 ASP n 
1 179 ALA n 
1 180 GLY n 
1 181 GLN n 
1 182 CYS n 
1 183 GLU n 
1 184 VAL n 
1 185 ASP n 
1 186 SER n 
1 187 LEU n 
1 188 ALA n 
1 189 GLY n 
1 190 TRP n 
1 191 LYS n 
1 192 PRO n 
1 193 SER n 
1 194 VAL n 
1 195 TYR n 
1 196 TYR n 
1 197 VAL n 
1 198 MET n 
1 199 LEU n 
1 200 ILE n 
1 201 LEU n 
1 202 CYS n 
1 203 THR n 
1 204 ALA n 
1 205 SER n 
1 206 ILE n 
1 207 LEU n 
1 208 ILE n 
1 209 SER n 
1 210 CYS n 
1 211 CYS n 
1 212 ALA n 
1 213 SER n 
1 214 ALA n 
1 215 MET n 
1 216 TYR n 
1 217 THR n 
1 218 PRO n 
1 219 ILE n 
1 220 GLU n 
1 221 GLY n 
1 222 TRP n 
1 223 SER n 
1 224 TYR n 
1 225 PHE n 
1 226 ASP n 
1 227 SER n 
1 228 LEU n 
1 229 TYR n 
1 230 PHE n 
1 231 CYS n 
1 232 PHE n 
1 233 VAL n 
1 234 ALA n 
1 235 PHE n 
1 236 SER n 
1 237 THR n 
1 238 ILE n 
1 239 GLY n 
1 240 PHE n 
1 241 GLY n 
1 242 ASP n 
1 243 LEU n 
1 244 VAL n 
1 245 SER n 
1 246 SER n 
1 247 GLN n 
1 248 ASN n 
1 249 ALA n 
1 250 HIS n 
1 251 TYR n 
1 252 GLU n 
1 253 SER n 
1 254 GLN n 
1 255 GLY n 
1 256 LEU n 
1 257 TYR n 
1 258 ARG n 
1 259 PHE n 
1 260 ALA n 
1 261 ASN n 
1 262 PHE n 
1 263 VAL n 
1 264 PHE n 
1 265 ILE n 
1 266 LEU n 
1 267 MET n 
1 268 GLY n 
1 269 VAL n 
1 270 CYS n 
1 271 CYS n 
1 272 ILE n 
1 273 TYR n 
1 274 SER n 
1 275 LEU n 
1 276 PHE n 
1 277 ASN n 
1 278 VAL n 
1 279 ILE n 
1 280 SER n 
1 281 ILE n 
1 282 LEU n 
1 283 ILE n 
1 284 LYS n 
1 285 GLN n 
1 286 SER n 
1 287 LEU n 
1 288 ASN n 
1 289 TRP n 
1 290 ILE n 
1 291 LEU n 
1 292 ARG n 
1 293 LYS n 
1 294 MET n 
1 295 ASP n 
1 296 SER n 
1 297 GLY n 
1 298 CYS n 
1 299 CYS n 
1 300 PRO n 
1 301 GLN n 
1 302 CYS n 
1 303 GLN n 
1 304 ARG n 
1 305 GLY n 
1 306 LEU n 
1 307 LEU n 
1 308 ARG n 
1 309 SER n 
1 310 ARG n 
1 311 ARG n 
1 312 ASN n 
1 313 VAL n 
1 314 VAL n 
1 315 MET n 
1 316 PRO n 
1 317 GLY n 
1 318 SER n 
1 319 VAL n 
1 320 ARG n 
1 321 ASN n 
1 322 ARG n 
1 323 CYS n 
1 324 ASN n 
1 325 ILE n 
1 326 SER n 
1 327 ILE n 
1 328 GLU n 
1 329 THR n 
1 330 ASP n 
1 331 GLY n 
1 332 VAL n 
1 333 ALA n 
1 334 GLU n 
1 335 SER n 
1 336 ASP n 
1 337 THR n 
1 338 ASP n 
1 339 GLY n 
1 340 ARG n 
1 341 ARG n 
1 342 LEU n 
1 343 SER n 
1 344 GLY n 
1 345 GLU n 
1 346 MET n 
1 347 ILE n 
1 348 SER n 
1 349 MET n 
1 350 LYS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   350 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 KCNK13 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               human 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ?                    'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ?                    'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ?                    'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                    'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ?                    'C3 H7 N O2 S'   121.158 
D12 non-polymer         . DODECANE        ?                    'C12 H26'        170.335 
EIC non-polymer         . 'LINOLEIC ACID' '9,12-LINOLEIC ACID' 'C18 H32 O2'     280.445 
GLN 'L-peptide linking' y GLUTAMINE       ?                    'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                    'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ?                    'C2 H5 N O2'     75.067  
HEX non-polymer         . HEXANE          ?                    'C6 H14'         86.175  
HIS 'L-peptide linking' y HISTIDINE       ?                    'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ?                    'C6 H13 N O2'    131.173 
K   non-polymer         . 'POTASSIUM ION' ?                    'K 1'            39.098  
LEU 'L-peptide linking' y LEUCINE         ?                    'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ?                    'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ?                    'C5 H11 N O2 S'  149.211 
OCT non-polymer         . N-OCTANE        ?                    'C8 H18'         114.229 
PHE 'L-peptide linking' y PHENYLALANINE   ?                    'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ?                    'C5 H9 N O2'     115.130 
R16 non-polymer         . HEXADECANE      ?                    'C16 H34'        226.441 
SER 'L-peptide linking' y SERINE          ?                    'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ?                    'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ?                    'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ?                    'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ?                    'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   U . n 
A 1 2   ALA 2   2   ?   ?   ?   U . n 
A 1 3   GLY 3   3   ?   ?   ?   U . n 
A 1 4   ARG 4   4   ?   ?   ?   U . n 
A 1 5   GLY 5   5   ?   ?   ?   U . n 
A 1 6   PHE 6   6   ?   ?   ?   U . n 
A 1 7   SER 7   7   ?   ?   ?   U . n 
A 1 8   TRP 8   8   ?   ?   ?   U . n 
A 1 9   GLY 9   9   ?   ?   ?   U . n 
A 1 10  PRO 10  10  ?   ?   ?   U . n 
A 1 11  GLY 11  11  ?   ?   ?   U . n 
A 1 12  HIS 12  12  ?   ?   ?   U . n 
A 1 13  LEU 13  13  ?   ?   ?   U . n 
A 1 14  ASN 14  14  14  ASN ASN U . n 
A 1 15  GLU 15  15  15  GLU GLU U . n 
A 1 16  ASP 16  16  16  ASP ASP U . n 
A 1 17  ASN 17  17  17  ASN ASN U . n 
A 1 18  ALA 18  18  18  ALA ALA U . n 
A 1 19  ARG 19  19  19  ARG ARG U . n 
A 1 20  PHE 20  20  20  PHE PHE U . n 
A 1 21  LEU 21  21  21  LEU LEU U . n 
A 1 22  LEU 22  22  22  LEU LEU U . n 
A 1 23  LEU 23  23  23  LEU LEU U . n 
A 1 24  ALA 24  24  24  ALA ALA U . n 
A 1 25  ALA 25  25  25  ALA ALA U . n 
A 1 26  LEU 26  26  26  LEU LEU U . n 
A 1 27  ILE 27  27  27  ILE ILE U . n 
A 1 28  VAL 28  28  28  VAL VAL U . n 
A 1 29  LEU 29  29  29  LEU LEU U . n 
A 1 30  TYR 30  30  30  TYR TYR U . n 
A 1 31  LEU 31  31  31  LEU LEU U . n 
A 1 32  LEU 32  32  32  LEU LEU U . n 
A 1 33  GLY 33  33  33  GLY GLY U . n 
A 1 34  GLY 34  34  34  GLY GLY U . n 
A 1 35  ALA 35  35  35  ALA ALA U . n 
A 1 36  ALA 36  36  36  ALA ALA U . n 
A 1 37  VAL 37  37  37  VAL VAL U . n 
A 1 38  PHE 38  38  38  PHE PHE U . n 
A 1 39  SER 39  39  39  SER SER U . n 
A 1 40  ALA 40  40  40  ALA ALA U . n 
A 1 41  LEU 41  41  41  LEU LEU U . n 
A 1 42  GLU 42  42  42  GLU GLU U . n 
A 1 43  LEU 43  43  43  LEU LEU U . n 
A 1 44  ALA 44  44  44  ALA ALA U . n 
A 1 45  HIS 45  45  45  HIS HIS U . n 
A 1 46  GLU 46  46  46  GLU GLU U . n 
A 1 47  ARG 47  47  47  ARG ARG U . n 
A 1 48  GLN 48  48  48  GLN GLN U . n 
A 1 49  ALA 49  49  49  ALA ALA U . n 
A 1 50  LYS 50  50  50  LYS LYS U . n 
A 1 51  GLN 51  51  51  GLN GLN U . n 
A 1 52  ARG 52  52  52  ARG ARG U . n 
A 1 53  TRP 53  53  53  TRP TRP U . n 
A 1 54  GLU 54  54  54  GLU GLU U . n 
A 1 55  GLU 55  55  55  GLU GLU U . n 
A 1 56  ARG 56  56  56  ARG ARG U . n 
A 1 57  LEU 57  57  57  LEU LEU U . n 
A 1 58  ALA 58  58  58  ALA ALA U . n 
A 1 59  GLN 59  59  59  GLN GLN U . n 
A 1 60  PHE 60  60  60  PHE PHE U . n 
A 1 61  SER 61  61  61  SER SER U . n 
A 1 62  ARG 62  62  62  ARG ARG U . n 
A 1 63  GLY 63  63  63  GLY GLY U . n 
A 1 64  HIS 64  64  64  HIS HIS U . n 
A 1 65  GLN 65  65  65  GLN GLN U . n 
A 1 66  LEU 66  66  66  LEU LEU U . n 
A 1 67  SER 67  67  67  SER SER U . n 
A 1 68  ARG 68  68  68  ARG ARG U . n 
A 1 69  ASP 69  69  69  ASP ASP U . n 
A 1 70  GLU 70  70  70  GLU GLU U . n 
A 1 71  LEU 71  71  71  LEU LEU U . n 
A 1 72  ARG 72  72  72  ARG ARG U . n 
A 1 73  GLY 73  73  73  GLY GLY U . n 
A 1 74  PHE 74  74  74  PHE PHE U . n 
A 1 75  LEU 75  75  75  LEU LEU U . n 
A 1 76  ARG 76  76  76  ARG ARG U . n 
A 1 77  HIS 77  77  77  HIS HIS U . n 
A 1 78  TYR 78  78  78  TYR TYR U . n 
A 1 79  GLU 79  79  79  GLU GLU U . n 
A 1 80  GLU 80  80  80  GLU GLU U . n 
A 1 81  ALA 81  81  81  ALA ALA U . n 
A 1 82  THR 82  82  82  THR THR U . n 
A 1 83  ARG 83  83  83  ARG ARG U . n 
A 1 84  ALA 84  84  84  ALA ALA U . n 
A 1 85  GLY 85  85  85  GLY GLY U . n 
A 1 86  ILE 86  86  86  ILE ILE U . n 
A 1 87  ARG 87  87  87  ARG ARG U . n 
A 1 88  VAL 88  88  88  VAL VAL U . n 
A 1 89  ASP 89  89  89  ASP ASP U . n 
A 1 90  ASN 90  90  90  ASN ASN U . n 
A 1 91  VAL 91  91  91  VAL VAL U . n 
A 1 92  ARG 92  92  92  ARG ARG U . n 
A 1 93  PRO 93  93  93  PRO PRO U . n 
A 1 94  ARG 94  94  94  ARG ARG U . n 
A 1 95  TRP 95  95  95  TRP TRP U . n 
A 1 96  ASP 96  96  96  ASP ASP U . n 
A 1 97  PHE 97  97  97  PHE PHE U . n 
A 1 98  THR 98  98  98  THR THR U . n 
A 1 99  GLY 99  99  99  GLY GLY U . n 
A 1 100 ALA 100 100 100 ALA ALA U . n 
A 1 101 PHE 101 101 101 PHE PHE U . n 
A 1 102 TYR 102 102 102 TYR TYR U . n 
A 1 103 PHE 103 103 103 PHE PHE U . n 
A 1 104 VAL 104 104 104 VAL VAL U . n 
A 1 105 GLY 105 105 105 GLY GLY U . n 
A 1 106 THR 106 106 106 THR THR U . n 
A 1 107 VAL 107 107 107 VAL VAL U . n 
A 1 108 VAL 108 108 108 VAL VAL U . n 
A 1 109 SER 109 109 109 SER SER U . n 
A 1 110 THR 110 110 110 THR THR U . n 
A 1 111 ILE 111 111 111 ILE ILE U . n 
A 1 112 GLY 112 112 112 GLY GLY U . n 
A 1 113 PHE 113 113 113 PHE PHE U . n 
A 1 114 GLY 114 114 114 GLY GLY U . n 
A 1 115 MET 115 115 115 MET MET U . n 
A 1 116 THR 116 116 116 THR THR U . n 
A 1 117 THR 117 117 117 THR THR U . n 
A 1 118 PRO 118 118 118 PRO PRO U . n 
A 1 119 ALA 119 119 119 ALA ALA U . n 
A 1 120 THR 120 120 120 THR THR U . n 
A 1 121 VAL 121 121 121 VAL VAL U . n 
A 1 122 GLY 122 122 122 GLY GLY U . n 
A 1 123 GLY 123 123 123 GLY GLY U . n 
A 1 124 LYS 124 124 124 LYS LYS U . n 
A 1 125 ILE 125 125 125 ILE ILE U . n 
A 1 126 PHE 126 126 126 PHE PHE U . n 
A 1 127 LEU 127 127 127 LEU LEU U . n 
A 1 128 ILE 128 128 128 ILE ILE U . n 
A 1 129 PHE 129 129 129 PHE PHE U . n 
A 1 130 TYR 130 130 130 TYR TYR U . n 
A 1 131 GLY 131 131 131 GLY GLY U . n 
A 1 132 LEU 132 132 132 LEU LEU U . n 
A 1 133 VAL 133 133 133 VAL VAL U . n 
A 1 134 GLY 134 134 134 GLY GLY U . n 
A 1 135 CYS 135 135 135 CYS CYS U . n 
A 1 136 SER 136 136 136 SER SER U . n 
A 1 137 SER 137 137 137 SER SER U . n 
A 1 138 THR 138 138 138 THR THR U . n 
A 1 139 ILE 139 139 139 ILE ILE U . n 
A 1 140 LEU 140 140 140 LEU LEU U . n 
A 1 141 PHE 141 141 141 PHE PHE U . n 
A 1 142 PHE 142 142 142 PHE PHE U . n 
A 1 143 ASN 143 143 143 ASN ASN U . n 
A 1 144 LEU 144 144 144 LEU LEU U . n 
A 1 145 PHE 145 145 145 PHE PHE U . n 
A 1 146 LEU 146 146 146 LEU LEU U . n 
A 1 147 GLU 147 147 147 GLU GLU U . n 
A 1 148 ARG 148 148 148 ARG ARG U . n 
A 1 149 LEU 149 149 149 LEU LEU U . n 
A 1 150 ILE 150 150 150 ILE ILE U . n 
A 1 151 THR 151 151 151 THR THR U . n 
A 1 152 ILE 152 152 152 ILE ILE U . n 
A 1 153 ILE 153 153 153 ILE ILE U . n 
A 1 154 ALA 154 154 154 ALA ALA U . n 
A 1 155 TYR 155 155 155 TYR TYR U . n 
A 1 156 ILE 156 156 156 ILE ILE U . n 
A 1 157 MET 157 157 157 MET MET U . n 
A 1 158 LYS 158 158 158 LYS LYS U . n 
A 1 159 SER 159 159 159 SER SER U . n 
A 1 160 CYS 160 160 160 CYS CYS U . n 
A 1 161 HIS 161 161 161 HIS HIS U . n 
A 1 162 GLN 162 162 162 GLN GLN U . n 
A 1 163 ARG 163 163 163 ARG ARG U . n 
A 1 164 GLN 164 164 164 GLN GLN U . n 
A 1 165 LEU 165 165 165 LEU LEU U . n 
A 1 166 ARG 166 166 166 ARG ARG U . n 
A 1 167 ARG 167 167 167 ARG ARG U . n 
A 1 168 ARG 168 168 ?   ?   ?   U . n 
A 1 169 GLY 169 169 ?   ?   ?   U . n 
A 1 170 ALA 170 170 ?   ?   ?   U . n 
A 1 171 LEU 171 171 ?   ?   ?   U . n 
A 1 172 PRO 172 172 ?   ?   ?   U . n 
A 1 173 GLN 173 173 ?   ?   ?   U . n 
A 1 174 GLU 174 174 ?   ?   ?   U . n 
A 1 175 SER 175 175 ?   ?   ?   U . n 
A 1 176 LEU 176 176 ?   ?   ?   U . n 
A 1 177 LYS 177 177 ?   ?   ?   U . n 
A 1 178 ASP 178 178 ?   ?   ?   U . n 
A 1 179 ALA 179 179 ?   ?   ?   U . n 
A 1 180 GLY 180 180 ?   ?   ?   U . n 
A 1 181 GLN 181 181 ?   ?   ?   U . n 
A 1 182 CYS 182 182 ?   ?   ?   U . n 
A 1 183 GLU 183 183 ?   ?   ?   U . n 
A 1 184 VAL 184 184 ?   ?   ?   U . n 
A 1 185 ASP 185 185 ?   ?   ?   U . n 
A 1 186 SER 186 186 ?   ?   ?   U . n 
A 1 187 LEU 187 187 ?   ?   ?   U . n 
A 1 188 ALA 188 188 188 ALA ALA U . n 
A 1 189 GLY 189 189 189 GLY GLY U . n 
A 1 190 TRP 190 190 190 TRP TRP U . n 
A 1 191 LYS 191 191 191 LYS LYS U . n 
A 1 192 PRO 192 192 192 PRO PRO U . n 
A 1 193 SER 193 193 193 SER SER U . n 
A 1 194 VAL 194 194 194 VAL VAL U . n 
A 1 195 TYR 195 195 195 TYR TYR U . n 
A 1 196 TYR 196 196 196 TYR TYR U . n 
A 1 197 VAL 197 197 197 VAL VAL U . n 
A 1 198 MET 198 198 198 MET MET U . n 
A 1 199 LEU 199 199 199 LEU LEU U . n 
A 1 200 ILE 200 200 200 ILE ILE U . n 
A 1 201 LEU 201 201 201 LEU LEU U . n 
A 1 202 CYS 202 202 202 CYS CYS U . n 
A 1 203 THR 203 203 203 THR THR U . n 
A 1 204 ALA 204 204 204 ALA ALA U . n 
A 1 205 SER 205 205 205 SER SER U . n 
A 1 206 ILE 206 206 206 ILE ILE U . n 
A 1 207 LEU 207 207 207 LEU LEU U . n 
A 1 208 ILE 208 208 208 ILE ILE U . n 
A 1 209 SER 209 209 209 SER SER U . n 
A 1 210 CYS 210 210 210 CYS CYS U . n 
A 1 211 CYS 211 211 211 CYS CYS U . n 
A 1 212 ALA 212 212 212 ALA ALA U . n 
A 1 213 SER 213 213 213 SER SER U . n 
A 1 214 ALA 214 214 214 ALA ALA U . n 
A 1 215 MET 215 215 215 MET MET U . n 
A 1 216 TYR 216 216 216 TYR TYR U . n 
A 1 217 THR 217 217 217 THR THR U . n 
A 1 218 PRO 218 218 218 PRO PRO U . n 
A 1 219 ILE 219 219 219 ILE ILE U . n 
A 1 220 GLU 220 220 220 GLU GLU U . n 
A 1 221 GLY 221 221 221 GLY GLY U . n 
A 1 222 TRP 222 222 222 TRP TRP U . n 
A 1 223 SER 223 223 223 SER SER U . n 
A 1 224 TYR 224 224 224 TYR TYR U . n 
A 1 225 PHE 225 225 225 PHE PHE U . n 
A 1 226 ASP 226 226 226 ASP ASP U . n 
A 1 227 SER 227 227 227 SER SER U . n 
A 1 228 LEU 228 228 228 LEU LEU U . n 
A 1 229 TYR 229 229 229 TYR TYR U . n 
A 1 230 PHE 230 230 230 PHE PHE U . n 
A 1 231 CYS 231 231 231 CYS CYS U . n 
A 1 232 PHE 232 232 232 PHE PHE U . n 
A 1 233 VAL 233 233 233 VAL VAL U . n 
A 1 234 ALA 234 234 234 ALA ALA U . n 
A 1 235 PHE 235 235 235 PHE PHE U . n 
A 1 236 SER 236 236 236 SER SER U . n 
A 1 237 THR 237 237 237 THR THR U . n 
A 1 238 ILE 238 238 238 ILE ILE U . n 
A 1 239 GLY 239 239 239 GLY GLY U . n 
A 1 240 PHE 240 240 240 PHE PHE U . n 
A 1 241 GLY 241 241 241 GLY GLY U . n 
A 1 242 ASP 242 242 242 ASP ASP U . n 
A 1 243 LEU 243 243 243 LEU LEU U . n 
A 1 244 VAL 244 244 244 VAL VAL U . n 
A 1 245 SER 245 245 245 SER SER U . n 
A 1 246 SER 246 246 246 SER SER U . n 
A 1 247 GLN 247 247 247 GLN GLN U . n 
A 1 248 ASN 248 248 248 ASN ASN U . n 
A 1 249 ALA 249 249 249 ALA ALA U . n 
A 1 250 HIS 250 250 250 HIS HIS U . n 
A 1 251 TYR 251 251 251 TYR TYR U . n 
A 1 252 GLU 252 252 252 GLU GLU U . n 
A 1 253 SER 253 253 253 SER SER U . n 
A 1 254 GLN 254 254 254 GLN GLN U . n 
A 1 255 GLY 255 255 255 GLY GLY U . n 
A 1 256 LEU 256 256 256 LEU LEU U . n 
A 1 257 TYR 257 257 257 TYR TYR U . n 
A 1 258 ARG 258 258 258 ARG ARG U . n 
A 1 259 PHE 259 259 259 PHE PHE U . n 
A 1 260 ALA 260 260 260 ALA ALA U . n 
A 1 261 ASN 261 261 261 ASN ASN U . n 
A 1 262 PHE 262 262 262 PHE PHE U . n 
A 1 263 VAL 263 263 263 VAL VAL U . n 
A 1 264 PHE 264 264 264 PHE PHE U . n 
A 1 265 ILE 265 265 265 ILE ILE U . n 
A 1 266 LEU 266 266 266 LEU LEU U . n 
A 1 267 MET 267 267 267 MET MET U . n 
A 1 268 GLY 268 268 268 GLY GLY U . n 
A 1 269 VAL 269 269 269 VAL VAL U . n 
A 1 270 CYS 270 270 270 CYS CYS U . n 
A 1 271 CYS 271 271 271 CYS CYS U . n 
A 1 272 ILE 272 272 272 ILE ILE U . n 
A 1 273 TYR 273 273 273 TYR TYR U . n 
A 1 274 SER 274 274 274 SER SER U . n 
A 1 275 LEU 275 275 275 LEU LEU U . n 
A 1 276 PHE 276 276 276 PHE PHE U . n 
A 1 277 ASN 277 277 277 ASN ASN U . n 
A 1 278 VAL 278 278 278 VAL VAL U . n 
A 1 279 ILE 279 279 279 ILE ILE U . n 
A 1 280 SER 280 280 280 SER SER U . n 
A 1 281 ILE 281 281 281 ILE ILE U . n 
A 1 282 LEU 282 282 282 LEU LEU U . n 
A 1 283 ILE 283 283 283 ILE ILE U . n 
A 1 284 LYS 284 284 284 LYS LYS U . n 
A 1 285 GLN 285 285 285 GLN GLN U . n 
A 1 286 SER 286 286 286 SER SER U . n 
A 1 287 LEU 287 287 287 LEU LEU U . n 
A 1 288 ASN 288 288 288 ASN ASN U . n 
A 1 289 TRP 289 289 289 TRP TRP U . n 
A 1 290 ILE 290 290 290 ILE ILE U . n 
A 1 291 LEU 291 291 291 LEU LEU U . n 
A 1 292 ARG 292 292 292 ARG ARG U . n 
A 1 293 LYS 293 293 293 LYS LYS U . n 
A 1 294 MET 294 294 294 MET MET U . n 
A 1 295 ASP 295 295 295 ASP ASP U . n 
A 1 296 SER 296 296 ?   ?   ?   U . n 
A 1 297 GLY 297 297 ?   ?   ?   U . n 
A 1 298 CYS 298 298 ?   ?   ?   U . n 
A 1 299 CYS 299 299 ?   ?   ?   U . n 
A 1 300 PRO 300 300 ?   ?   ?   U . n 
A 1 301 GLN 301 301 ?   ?   ?   U . n 
A 1 302 CYS 302 302 ?   ?   ?   U . n 
A 1 303 GLN 303 303 ?   ?   ?   U . n 
A 1 304 ARG 304 304 ?   ?   ?   U . n 
A 1 305 GLY 305 305 ?   ?   ?   U . n 
A 1 306 LEU 306 306 ?   ?   ?   U . n 
A 1 307 LEU 307 307 ?   ?   ?   U . n 
A 1 308 ARG 308 308 ?   ?   ?   U . n 
A 1 309 SER 309 309 ?   ?   ?   U . n 
A 1 310 ARG 310 310 ?   ?   ?   U . n 
A 1 311 ARG 311 311 ?   ?   ?   U . n 
A 1 312 ASN 312 312 ?   ?   ?   U . n 
A 1 313 VAL 313 313 ?   ?   ?   U . n 
A 1 314 VAL 314 314 ?   ?   ?   U . n 
A 1 315 MET 315 315 ?   ?   ?   U . n 
A 1 316 PRO 316 316 ?   ?   ?   U . n 
A 1 317 GLY 317 317 ?   ?   ?   U . n 
A 1 318 SER 318 318 ?   ?   ?   U . n 
A 1 319 VAL 319 319 ?   ?   ?   U . n 
A 1 320 ARG 320 320 ?   ?   ?   U . n 
A 1 321 ASN 321 321 ?   ?   ?   U . n 
A 1 322 ARG 322 322 ?   ?   ?   U . n 
A 1 323 CYS 323 323 ?   ?   ?   U . n 
A 1 324 ASN 324 324 ?   ?   ?   U . n 
A 1 325 ILE 325 325 ?   ?   ?   U . n 
A 1 326 SER 326 326 ?   ?   ?   U . n 
A 1 327 ILE 327 327 ?   ?   ?   U . n 
A 1 328 GLU 328 328 ?   ?   ?   U . n 
A 1 329 THR 329 329 ?   ?   ?   U . n 
A 1 330 ASP 330 330 ?   ?   ?   U . n 
A 1 331 GLY 331 331 ?   ?   ?   U . n 
A 1 332 VAL 332 332 ?   ?   ?   U . n 
A 1 333 ALA 333 333 ?   ?   ?   U . n 
A 1 334 GLU 334 334 ?   ?   ?   U . n 
A 1 335 SER 335 335 ?   ?   ?   U . n 
A 1 336 ASP 336 336 ?   ?   ?   U . n 
A 1 337 THR 337 337 ?   ?   ?   U . n 
A 1 338 ASP 338 338 ?   ?   ?   U . n 
A 1 339 GLY 339 339 ?   ?   ?   U . n 
A 1 340 ARG 340 340 ?   ?   ?   U . n 
A 1 341 ARG 341 341 ?   ?   ?   U . n 
A 1 342 LEU 342 342 ?   ?   ?   U . n 
A 1 343 SER 343 343 ?   ?   ?   U . n 
A 1 344 GLY 344 344 ?   ?   ?   U . n 
A 1 345 GLU 345 345 ?   ?   ?   U . n 
A 1 346 MET 346 346 ?   ?   ?   U . n 
A 1 347 ILE 347 347 ?   ?   ?   U . n 
A 1 348 SER 348 348 ?   ?   ?   U . n 
A 1 349 MET 349 349 ?   ?   ?   U . n 
A 1 350 LYS 350 350 ?   ?   ?   U . n 
B 1 1   MET 1   1   ?   ?   ?   A . n 
B 1 2   ALA 2   2   ?   ?   ?   A . n 
B 1 3   GLY 3   3   ?   ?   ?   A . n 
B 1 4   ARG 4   4   ?   ?   ?   A . n 
B 1 5   GLY 5   5   ?   ?   ?   A . n 
B 1 6   PHE 6   6   ?   ?   ?   A . n 
B 1 7   SER 7   7   ?   ?   ?   A . n 
B 1 8   TRP 8   8   ?   ?   ?   A . n 
B 1 9   GLY 9   9   ?   ?   ?   A . n 
B 1 10  PRO 10  10  ?   ?   ?   A . n 
B 1 11  GLY 11  11  ?   ?   ?   A . n 
B 1 12  HIS 12  12  ?   ?   ?   A . n 
B 1 13  LEU 13  13  ?   ?   ?   A . n 
B 1 14  ASN 14  14  14  ASN ASN A . n 
B 1 15  GLU 15  15  15  GLU GLU A . n 
B 1 16  ASP 16  16  16  ASP ASP A . n 
B 1 17  ASN 17  17  17  ASN ASN A . n 
B 1 18  ALA 18  18  18  ALA ALA A . n 
B 1 19  ARG 19  19  19  ARG ARG A . n 
B 1 20  PHE 20  20  20  PHE PHE A . n 
B 1 21  LEU 21  21  21  LEU LEU A . n 
B 1 22  LEU 22  22  22  LEU LEU A . n 
B 1 23  LEU 23  23  23  LEU LEU A . n 
B 1 24  ALA 24  24  24  ALA ALA A . n 
B 1 25  ALA 25  25  25  ALA ALA A . n 
B 1 26  LEU 26  26  26  LEU LEU A . n 
B 1 27  ILE 27  27  27  ILE ILE A . n 
B 1 28  VAL 28  28  28  VAL VAL A . n 
B 1 29  LEU 29  29  29  LEU LEU A . n 
B 1 30  TYR 30  30  30  TYR TYR A . n 
B 1 31  LEU 31  31  31  LEU LEU A . n 
B 1 32  LEU 32  32  32  LEU LEU A . n 
B 1 33  GLY 33  33  33  GLY GLY A . n 
B 1 34  GLY 34  34  34  GLY GLY A . n 
B 1 35  ALA 35  35  35  ALA ALA A . n 
B 1 36  ALA 36  36  36  ALA ALA A . n 
B 1 37  VAL 37  37  37  VAL VAL A . n 
B 1 38  PHE 38  38  38  PHE PHE A . n 
B 1 39  SER 39  39  39  SER SER A . n 
B 1 40  ALA 40  40  40  ALA ALA A . n 
B 1 41  LEU 41  41  41  LEU LEU A . n 
B 1 42  GLU 42  42  42  GLU GLU A . n 
B 1 43  LEU 43  43  43  LEU LEU A . n 
B 1 44  ALA 44  44  44  ALA ALA A . n 
B 1 45  HIS 45  45  45  HIS HIS A . n 
B 1 46  GLU 46  46  46  GLU GLU A . n 
B 1 47  ARG 47  47  47  ARG ARG A . n 
B 1 48  GLN 48  48  48  GLN GLN A . n 
B 1 49  ALA 49  49  49  ALA ALA A . n 
B 1 50  LYS 50  50  50  LYS LYS A . n 
B 1 51  GLN 51  51  51  GLN GLN A . n 
B 1 52  ARG 52  52  52  ARG ARG A . n 
B 1 53  TRP 53  53  53  TRP TRP A . n 
B 1 54  GLU 54  54  54  GLU GLU A . n 
B 1 55  GLU 55  55  55  GLU GLU A . n 
B 1 56  ARG 56  56  56  ARG ARG A . n 
B 1 57  LEU 57  57  57  LEU LEU A . n 
B 1 58  ALA 58  58  58  ALA ALA A . n 
B 1 59  GLN 59  59  59  GLN GLN A . n 
B 1 60  PHE 60  60  60  PHE PHE A . n 
B 1 61  SER 61  61  61  SER SER A . n 
B 1 62  ARG 62  62  62  ARG ARG A . n 
B 1 63  GLY 63  63  63  GLY GLY A . n 
B 1 64  HIS 64  64  64  HIS HIS A . n 
B 1 65  GLN 65  65  65  GLN GLN A . n 
B 1 66  LEU 66  66  66  LEU LEU A . n 
B 1 67  SER 67  67  67  SER SER A . n 
B 1 68  ARG 68  68  68  ARG ARG A . n 
B 1 69  ASP 69  69  69  ASP ASP A . n 
B 1 70  GLU 70  70  70  GLU GLU A . n 
B 1 71  LEU 71  71  71  LEU LEU A . n 
B 1 72  ARG 72  72  72  ARG ARG A . n 
B 1 73  GLY 73  73  73  GLY GLY A . n 
B 1 74  PHE 74  74  74  PHE PHE A . n 
B 1 75  LEU 75  75  75  LEU LEU A . n 
B 1 76  ARG 76  76  76  ARG ARG A . n 
B 1 77  HIS 77  77  77  HIS HIS A . n 
B 1 78  TYR 78  78  78  TYR TYR A . n 
B 1 79  GLU 79  79  79  GLU GLU A . n 
B 1 80  GLU 80  80  80  GLU GLU A . n 
B 1 81  ALA 81  81  81  ALA ALA A . n 
B 1 82  THR 82  82  82  THR THR A . n 
B 1 83  ARG 83  83  83  ARG ARG A . n 
B 1 84  ALA 84  84  84  ALA ALA A . n 
B 1 85  GLY 85  85  85  GLY GLY A . n 
B 1 86  ILE 86  86  86  ILE ILE A . n 
B 1 87  ARG 87  87  87  ARG ARG A . n 
B 1 88  VAL 88  88  88  VAL VAL A . n 
B 1 89  ASP 89  89  89  ASP ASP A . n 
B 1 90  ASN 90  90  90  ASN ASN A . n 
B 1 91  VAL 91  91  91  VAL VAL A . n 
B 1 92  ARG 92  92  92  ARG ARG A . n 
B 1 93  PRO 93  93  93  PRO PRO A . n 
B 1 94  ARG 94  94  94  ARG ARG A . n 
B 1 95  TRP 95  95  95  TRP TRP A . n 
B 1 96  ASP 96  96  96  ASP ASP A . n 
B 1 97  PHE 97  97  97  PHE PHE A . n 
B 1 98  THR 98  98  98  THR THR A . n 
B 1 99  GLY 99  99  99  GLY GLY A . n 
B 1 100 ALA 100 100 100 ALA ALA A . n 
B 1 101 PHE 101 101 101 PHE PHE A . n 
B 1 102 TYR 102 102 102 TYR TYR A . n 
B 1 103 PHE 103 103 103 PHE PHE A . n 
B 1 104 VAL 104 104 104 VAL VAL A . n 
B 1 105 GLY 105 105 105 GLY GLY A . n 
B 1 106 THR 106 106 106 THR THR A . n 
B 1 107 VAL 107 107 107 VAL VAL A . n 
B 1 108 VAL 108 108 108 VAL VAL A . n 
B 1 109 SER 109 109 109 SER SER A . n 
B 1 110 THR 110 110 110 THR THR A . n 
B 1 111 ILE 111 111 111 ILE ILE A . n 
B 1 112 GLY 112 112 112 GLY GLY A . n 
B 1 113 PHE 113 113 113 PHE PHE A . n 
B 1 114 GLY 114 114 114 GLY GLY A . n 
B 1 115 MET 115 115 115 MET MET A . n 
B 1 116 THR 116 116 116 THR THR A . n 
B 1 117 THR 117 117 117 THR THR A . n 
B 1 118 PRO 118 118 118 PRO PRO A . n 
B 1 119 ALA 119 119 119 ALA ALA A . n 
B 1 120 THR 120 120 120 THR THR A . n 
B 1 121 VAL 121 121 121 VAL VAL A . n 
B 1 122 GLY 122 122 122 GLY GLY A . n 
B 1 123 GLY 123 123 123 GLY GLY A . n 
B 1 124 LYS 124 124 124 LYS LYS A . n 
B 1 125 ILE 125 125 125 ILE ILE A . n 
B 1 126 PHE 126 126 126 PHE PHE A . n 
B 1 127 LEU 127 127 127 LEU LEU A . n 
B 1 128 ILE 128 128 128 ILE ILE A . n 
B 1 129 PHE 129 129 129 PHE PHE A . n 
B 1 130 TYR 130 130 130 TYR TYR A . n 
B 1 131 GLY 131 131 131 GLY GLY A . n 
B 1 132 LEU 132 132 132 LEU LEU A . n 
B 1 133 VAL 133 133 133 VAL VAL A . n 
B 1 134 GLY 134 134 134 GLY GLY A . n 
B 1 135 CYS 135 135 135 CYS CYS A . n 
B 1 136 SER 136 136 136 SER SER A . n 
B 1 137 SER 137 137 137 SER SER A . n 
B 1 138 THR 138 138 138 THR THR A . n 
B 1 139 ILE 139 139 139 ILE ILE A . n 
B 1 140 LEU 140 140 140 LEU LEU A . n 
B 1 141 PHE 141 141 141 PHE PHE A . n 
B 1 142 PHE 142 142 142 PHE PHE A . n 
B 1 143 ASN 143 143 143 ASN ASN A . n 
B 1 144 LEU 144 144 144 LEU LEU A . n 
B 1 145 PHE 145 145 145 PHE PHE A . n 
B 1 146 LEU 146 146 146 LEU LEU A . n 
B 1 147 GLU 147 147 147 GLU GLU A . n 
B 1 148 ARG 148 148 148 ARG ARG A . n 
B 1 149 LEU 149 149 149 LEU LEU A . n 
B 1 150 ILE 150 150 150 ILE ILE A . n 
B 1 151 THR 151 151 151 THR THR A . n 
B 1 152 ILE 152 152 152 ILE ILE A . n 
B 1 153 ILE 153 153 153 ILE ILE A . n 
B 1 154 ALA 154 154 154 ALA ALA A . n 
B 1 155 TYR 155 155 155 TYR TYR A . n 
B 1 156 ILE 156 156 156 ILE ILE A . n 
B 1 157 MET 157 157 157 MET MET A . n 
B 1 158 LYS 158 158 158 LYS LYS A . n 
B 1 159 SER 159 159 159 SER SER A . n 
B 1 160 CYS 160 160 160 CYS CYS A . n 
B 1 161 HIS 161 161 161 HIS HIS A . n 
B 1 162 GLN 162 162 162 GLN GLN A . n 
B 1 163 ARG 163 163 163 ARG ARG A . n 
B 1 164 GLN 164 164 164 GLN GLN A . n 
B 1 165 LEU 165 165 165 LEU LEU A . n 
B 1 166 ARG 166 166 166 ARG ARG A . n 
B 1 167 ARG 167 167 167 ARG ARG A . n 
B 1 168 ARG 168 168 ?   ?   ?   A . n 
B 1 169 GLY 169 169 ?   ?   ?   A . n 
B 1 170 ALA 170 170 ?   ?   ?   A . n 
B 1 171 LEU 171 171 ?   ?   ?   A . n 
B 1 172 PRO 172 172 ?   ?   ?   A . n 
B 1 173 GLN 173 173 ?   ?   ?   A . n 
B 1 174 GLU 174 174 ?   ?   ?   A . n 
B 1 175 SER 175 175 ?   ?   ?   A . n 
B 1 176 LEU 176 176 ?   ?   ?   A . n 
B 1 177 LYS 177 177 ?   ?   ?   A . n 
B 1 178 ASP 178 178 ?   ?   ?   A . n 
B 1 179 ALA 179 179 ?   ?   ?   A . n 
B 1 180 GLY 180 180 ?   ?   ?   A . n 
B 1 181 GLN 181 181 ?   ?   ?   A . n 
B 1 182 CYS 182 182 ?   ?   ?   A . n 
B 1 183 GLU 183 183 ?   ?   ?   A . n 
B 1 184 VAL 184 184 ?   ?   ?   A . n 
B 1 185 ASP 185 185 ?   ?   ?   A . n 
B 1 186 SER 186 186 ?   ?   ?   A . n 
B 1 187 LEU 187 187 ?   ?   ?   A . n 
B 1 188 ALA 188 188 188 ALA ALA A . n 
B 1 189 GLY 189 189 189 GLY GLY A . n 
B 1 190 TRP 190 190 190 TRP TRP A . n 
B 1 191 LYS 191 191 191 LYS LYS A . n 
B 1 192 PRO 192 192 192 PRO PRO A . n 
B 1 193 SER 193 193 193 SER SER A . n 
B 1 194 VAL 194 194 194 VAL VAL A . n 
B 1 195 TYR 195 195 195 TYR TYR A . n 
B 1 196 TYR 196 196 196 TYR TYR A . n 
B 1 197 VAL 197 197 197 VAL VAL A . n 
B 1 198 MET 198 198 198 MET MET A . n 
B 1 199 LEU 199 199 199 LEU LEU A . n 
B 1 200 ILE 200 200 200 ILE ILE A . n 
B 1 201 LEU 201 201 201 LEU LEU A . n 
B 1 202 CYS 202 202 202 CYS CYS A . n 
B 1 203 THR 203 203 203 THR THR A . n 
B 1 204 ALA 204 204 204 ALA ALA A . n 
B 1 205 SER 205 205 205 SER SER A . n 
B 1 206 ILE 206 206 206 ILE ILE A . n 
B 1 207 LEU 207 207 207 LEU LEU A . n 
B 1 208 ILE 208 208 208 ILE ILE A . n 
B 1 209 SER 209 209 209 SER SER A . n 
B 1 210 CYS 210 210 210 CYS CYS A . n 
B 1 211 CYS 211 211 211 CYS CYS A . n 
B 1 212 ALA 212 212 212 ALA ALA A . n 
B 1 213 SER 213 213 213 SER SER A . n 
B 1 214 ALA 214 214 214 ALA ALA A . n 
B 1 215 MET 215 215 215 MET MET A . n 
B 1 216 TYR 216 216 216 TYR TYR A . n 
B 1 217 THR 217 217 217 THR THR A . n 
B 1 218 PRO 218 218 218 PRO PRO A . n 
B 1 219 ILE 219 219 219 ILE ILE A . n 
B 1 220 GLU 220 220 220 GLU GLU A . n 
B 1 221 GLY 221 221 221 GLY GLY A . n 
B 1 222 TRP 222 222 222 TRP TRP A . n 
B 1 223 SER 223 223 223 SER SER A . n 
B 1 224 TYR 224 224 224 TYR TYR A . n 
B 1 225 PHE 225 225 225 PHE PHE A . n 
B 1 226 ASP 226 226 226 ASP ASP A . n 
B 1 227 SER 227 227 227 SER SER A . n 
B 1 228 LEU 228 228 228 LEU LEU A . n 
B 1 229 TYR 229 229 229 TYR TYR A . n 
B 1 230 PHE 230 230 230 PHE PHE A . n 
B 1 231 CYS 231 231 231 CYS CYS A . n 
B 1 232 PHE 232 232 232 PHE PHE A . n 
B 1 233 VAL 233 233 233 VAL VAL A . n 
B 1 234 ALA 234 234 234 ALA ALA A . n 
B 1 235 PHE 235 235 235 PHE PHE A . n 
B 1 236 SER 236 236 236 SER SER A . n 
B 1 237 THR 237 237 237 THR THR A . n 
B 1 238 ILE 238 238 238 ILE ILE A . n 
B 1 239 GLY 239 239 239 GLY GLY A . n 
B 1 240 PHE 240 240 240 PHE PHE A . n 
B 1 241 GLY 241 241 241 GLY GLY A . n 
B 1 242 ASP 242 242 242 ASP ASP A . n 
B 1 243 LEU 243 243 243 LEU LEU A . n 
B 1 244 VAL 244 244 244 VAL VAL A . n 
B 1 245 SER 245 245 245 SER SER A . n 
B 1 246 SER 246 246 246 SER SER A . n 
B 1 247 GLN 247 247 247 GLN GLN A . n 
B 1 248 ASN 248 248 248 ASN ASN A . n 
B 1 249 ALA 249 249 249 ALA ALA A . n 
B 1 250 HIS 250 250 250 HIS HIS A . n 
B 1 251 TYR 251 251 251 TYR TYR A . n 
B 1 252 GLU 252 252 252 GLU GLU A . n 
B 1 253 SER 253 253 253 SER SER A . n 
B 1 254 GLN 254 254 254 GLN GLN A . n 
B 1 255 GLY 255 255 255 GLY GLY A . n 
B 1 256 LEU 256 256 256 LEU LEU A . n 
B 1 257 TYR 257 257 257 TYR TYR A . n 
B 1 258 ARG 258 258 258 ARG ARG A . n 
B 1 259 PHE 259 259 259 PHE PHE A . n 
B 1 260 ALA 260 260 260 ALA ALA A . n 
B 1 261 ASN 261 261 261 ASN ASN A . n 
B 1 262 PHE 262 262 262 PHE PHE A . n 
B 1 263 VAL 263 263 263 VAL VAL A . n 
B 1 264 PHE 264 264 264 PHE PHE A . n 
B 1 265 ILE 265 265 265 ILE ILE A . n 
B 1 266 LEU 266 266 266 LEU LEU A . n 
B 1 267 MET 267 267 267 MET MET A . n 
B 1 268 GLY 268 268 268 GLY GLY A . n 
B 1 269 VAL 269 269 269 VAL VAL A . n 
B 1 270 CYS 270 270 270 CYS CYS A . n 
B 1 271 CYS 271 271 271 CYS CYS A . n 
B 1 272 ILE 272 272 272 ILE ILE A . n 
B 1 273 TYR 273 273 273 TYR TYR A . n 
B 1 274 SER 274 274 274 SER SER A . n 
B 1 275 LEU 275 275 275 LEU LEU A . n 
B 1 276 PHE 276 276 276 PHE PHE A . n 
B 1 277 ASN 277 277 277 ASN ASN A . n 
B 1 278 VAL 278 278 278 VAL VAL A . n 
B 1 279 ILE 279 279 279 ILE ILE A . n 
B 1 280 SER 280 280 280 SER SER A . n 
B 1 281 ILE 281 281 281 ILE ILE A . n 
B 1 282 LEU 282 282 282 LEU LEU A . n 
B 1 283 ILE 283 283 283 ILE ILE A . n 
B 1 284 LYS 284 284 284 LYS LYS A . n 
B 1 285 GLN 285 285 285 GLN GLN A . n 
B 1 286 SER 286 286 286 SER SER A . n 
B 1 287 LEU 287 287 287 LEU LEU A . n 
B 1 288 ASN 288 288 288 ASN ASN A . n 
B 1 289 TRP 289 289 289 TRP TRP A . n 
B 1 290 ILE 290 290 290 ILE ILE A . n 
B 1 291 LEU 291 291 291 LEU LEU A . n 
B 1 292 ARG 292 292 292 ARG ARG A . n 
B 1 293 LYS 293 293 293 LYS LYS A . n 
B 1 294 MET 294 294 294 MET MET A . n 
B 1 295 ASP 295 295 295 ASP ASP A . n 
B 1 296 SER 296 296 ?   ?   ?   A . n 
B 1 297 GLY 297 297 ?   ?   ?   A . n 
B 1 298 CYS 298 298 ?   ?   ?   A . n 
B 1 299 CYS 299 299 ?   ?   ?   A . n 
B 1 300 PRO 300 300 ?   ?   ?   A . n 
B 1 301 GLN 301 301 ?   ?   ?   A . n 
B 1 302 CYS 302 302 ?   ?   ?   A . n 
B 1 303 GLN 303 303 ?   ?   ?   A . n 
B 1 304 ARG 304 304 ?   ?   ?   A . n 
B 1 305 GLY 305 305 ?   ?   ?   A . n 
B 1 306 LEU 306 306 ?   ?   ?   A . n 
B 1 307 LEU 307 307 ?   ?   ?   A . n 
B 1 308 ARG 308 308 ?   ?   ?   A . n 
B 1 309 SER 309 309 ?   ?   ?   A . n 
B 1 310 ARG 310 310 ?   ?   ?   A . n 
B 1 311 ARG 311 311 ?   ?   ?   A . n 
B 1 312 ASN 312 312 ?   ?   ?   A . n 
B 1 313 VAL 313 313 ?   ?   ?   A . n 
B 1 314 VAL 314 314 ?   ?   ?   A . n 
B 1 315 MET 315 315 ?   ?   ?   A . n 
B 1 316 PRO 316 316 ?   ?   ?   A . n 
B 1 317 GLY 317 317 ?   ?   ?   A . n 
B 1 318 SER 318 318 ?   ?   ?   A . n 
B 1 319 VAL 319 319 ?   ?   ?   A . n 
B 1 320 ARG 320 320 ?   ?   ?   A . n 
B 1 321 ASN 321 321 ?   ?   ?   A . n 
B 1 322 ARG 322 322 ?   ?   ?   A . n 
B 1 323 CYS 323 323 ?   ?   ?   A . n 
B 1 324 ASN 324 324 ?   ?   ?   A . n 
B 1 325 ILE 325 325 ?   ?   ?   A . n 
B 1 326 SER 326 326 ?   ?   ?   A . n 
B 1 327 ILE 327 327 ?   ?   ?   A . n 
B 1 328 GLU 328 328 ?   ?   ?   A . n 
B 1 329 THR 329 329 ?   ?   ?   A . n 
B 1 330 ASP 330 330 ?   ?   ?   A . n 
B 1 331 GLY 331 331 ?   ?   ?   A . n 
B 1 332 VAL 332 332 ?   ?   ?   A . n 
B 1 333 ALA 333 333 ?   ?   ?   A . n 
B 1 334 GLU 334 334 ?   ?   ?   A . n 
B 1 335 SER 335 335 ?   ?   ?   A . n 
B 1 336 ASP 336 336 ?   ?   ?   A . n 
B 1 337 THR 337 337 ?   ?   ?   A . n 
B 1 338 ASP 338 338 ?   ?   ?   A . n 
B 1 339 GLY 339 339 ?   ?   ?   A . n 
B 1 340 ARG 340 340 ?   ?   ?   A . n 
B 1 341 ARG 341 341 ?   ?   ?   A . n 
B 1 342 LEU 342 342 ?   ?   ?   A . n 
B 1 343 SER 343 343 ?   ?   ?   A . n 
B 1 344 GLY 344 344 ?   ?   ?   A . n 
B 1 345 GLU 345 345 ?   ?   ?   A . n 
B 1 346 MET 346 346 ?   ?   ?   A . n 
B 1 347 ILE 347 347 ?   ?   ?   A . n 
B 1 348 SER 348 348 ?   ?   ?   A . n 
B 1 349 MET 349 349 ?   ?   ?   A . n 
B 1 350 LYS 350 350 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        EIC 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   EIC 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C  2 HEX 1 401 309 HEX D06 U . 
D  3 D12 1 402 310 D12 D12 U . 
E  2 HEX 1 403 311 HEX D06 U . 
F  4 OCT 1 404 313 OCT D08 U . 
G  5 R16 1 405 314 R16 D16 U . 
H  4 OCT 1 406 315 OCT D08 U . 
I  4 OCT 1 407 316 OCT D08 U . 
J  4 OCT 1 408 317 OCT D08 U . 
K  4 OCT 1 409 318 OCT D08 U . 
L  3 D12 1 410 319 D12 D12 U . 
M  3 D12 1 411 320 D12 D12 U . 
N  4 OCT 1 412 321 OCT D08 U . 
O  6 EIC 1 413 322 EIC EIC U . 
P  3 D12 1 414 323 D12 D12 U . 
Q  3 D12 1 401 307 D12 D12 A . 
R  2 HEX 1 402 309 HEX D06 A . 
S  4 OCT 1 403 311 OCT D08 A . 
T  5 R16 1 404 312 R16 D16 A . 
U  4 OCT 1 405 313 OCT D08 A . 
V  4 OCT 1 406 314 OCT D08 A . 
W  4 OCT 1 407 315 OCT D08 A . 
X  4 OCT 1 408 316 OCT D08 A . 
Y  3 D12 1 409 317 D12 D12 A . 
Z  3 D12 1 410 318 D12 D12 A . 
AA 2 HEX 1 411 319 HEX D06 A . 
BA 4 OCT 1 412 320 OCT D08 A . 
CA 6 EIC 1 413 321 EIC EIC A . 
DA 3 D12 1 414 322 D12 D12 A . 
EA 7 K   1 415 2   K   K   A . 
FA 7 K   1 416 3   K   K   A . 
GA 7 K   1 417 4   K   K   A . 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BYI 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BYI 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BYI 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     9BYI 
_struct.title                        'Structure of human K2P13.1 (THIK1) in detergent' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BYI 
_struct_keywords.text            'ion channel, k2p channel, membrane protein, TRANSPORT PROTEIN' 
_struct_keywords.pdbx_keywords   'TRANSPORT PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A  N N 1 ? 
B  N N 1 ? 
C  N N 2 ? 
D  N N 3 ? 
E  N N 2 ? 
F  N N 4 ? 
G  N N 5 ? 
H  N N 4 ? 
I  N N 4 ? 
J  N N 4 ? 
K  N N 4 ? 
L  N N 3 ? 
M  N N 3 ? 
N  N N 4 ? 
O  N N 6 ? 
P  N N 3 ? 
Q  N N 3 ? 
R  N N 2 ? 
S  N N 4 ? 
T  N N 5 ? 
U  N N 4 ? 
V  N N 4 ? 
W  N N 4 ? 
X  N N 4 ? 
Y  N N 3 ? 
Z  N N 3 ? 
AA N N 2 ? 
BA N N 4 ? 
CA N N 6 ? 
DA N N 3 ? 
EA N N 7 ? 
FA N N 7 ? 
GA N N 7 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    KCNKD_HUMAN 
_struct_ref.pdbx_db_accession          Q9HB14 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MAGRGFSWGPGHLNEDNARFLLLAALIVLYLLGGAAVFSALELAHERQAKQRWEERLANFSRGHNLSRDELRGFLRHYEE
ATRAGIRVDNVRPRWDFTGAFYFVGTVVSTIGFGMTTPATVGGKIFLIFYGLVGCSSTILFFNLFLERLITIIAYIMKSC
HQRQLRRRGALPQESLKDAGQCEVDSLAGWKPSVYYVMLILCTASILISCCASAMYTPIEGWSYFDSLYFCFVAFSTIGF
GDLVSSQNAHYESQGLYRFANFVFILMGVCCIYSLFNVISILIKQSLNWILRKMDSGCCPQCQRGLLRSRRNVVMPGSVR
NRCNISIETDGVAESDTDGRRLSGEMISMK
;
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9BYI U 1 ? 350 ? Q9HB14 1 ? 350 ? 1 350 
2 1 9BYI A 1 ? 350 ? Q9HB14 1 ? 350 ? 1 350 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9BYI GLN U 59 ? UNP Q9HB14 ASN 59 'engineered mutation' 59 1 
1 9BYI GLN U 65 ? UNP Q9HB14 ASN 65 'engineered mutation' 65 2 
2 9BYI GLN A 59 ? UNP Q9HB14 ASN 59 'engineered mutation' 59 3 
2 9BYI GLN A 65 ? UNP Q9HB14 ASN 65 'engineered mutation' 65 4 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V,W,X,Y,Z,AA,BA,CA,DA,EA,FA,GA 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 14  ? HIS A 64  ? ASN U 14  HIS U 64  1 ? 51 
HELX_P HELX_P2  AA2 ARG A 68  ? GLY A 85  ? ARG U 68  GLY U 85  1 ? 18 
HELX_P HELX_P3  AA3 ASP A 96  ? SER A 109 ? ASP U 96  SER U 109 1 ? 14 
HELX_P HELX_P4  AA4 LYS A 124 ? ARG A 166 ? LYS U 124 ARG U 166 1 ? 43 
HELX_P HELX_P5  AA5 SER A 193 ? MET A 215 ? SER U 193 MET U 215 1 ? 23 
HELX_P HELX_P6  AA6 SER A 223 ? SER A 236 ? SER U 223 SER U 236 1 ? 14 
HELX_P HELX_P7  AA7 GLY A 255 ? ASP A 295 ? GLY U 255 ASP U 295 1 ? 41 
HELX_P HELX_P8  AA8 GLU B 15  ? HIS B 64  ? GLU A 15  HIS A 64  1 ? 50 
HELX_P HELX_P9  AA9 ARG B 68  ? ALA B 84  ? ARG A 68  ALA A 84  1 ? 17 
HELX_P HELX_P10 AB1 PHE B 97  ? SER B 109 ? PHE A 97  SER A 109 1 ? 13 
HELX_P HELX_P11 AB2 LYS B 124 ? ARG B 166 ? LYS A 124 ARG A 166 1 ? 43 
HELX_P HELX_P12 AB3 SER B 193 ? MET B 215 ? SER A 193 MET A 215 1 ? 23 
HELX_P HELX_P13 AB4 SER B 223 ? SER B 236 ? SER A 223 SER A 236 1 ? 14 
HELX_P HELX_P14 AB5 GLY B 255 ? MET B 294 ? GLY A 255 MET A 294 1 ? 40 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A THR 110 O ? ? ? 1_555 EA K . K ? ? U THR 110 A K 415 1_555 ? ? ? ? ? ? ? 3.152 ? ? 
metalc2  metalc ? ? A THR 110 O ? ? ? 1_555 FA K . K ? ? U THR 110 A K 416 1_555 ? ? ? ? ? ? ? 2.841 ? ? 
metalc3  metalc ? ? A ILE 111 O ? ? ? 1_555 EA K . K ? ? U ILE 111 A K 415 1_555 ? ? ? ? ? ? ? 2.955 ? ? 
metalc4  metalc ? ? A GLY 112 O ? ? ? 1_555 GA K . K ? ? U GLY 112 A K 417 1_555 ? ? ? ? ? ? ? 2.793 ? ? 
metalc5  metalc ? ? A PHE 113 O ? ? ? 1_555 GA K . K ? ? U PHE 113 A K 417 1_555 ? ? ? ? ? ? ? 3.264 ? ? 
metalc6  metalc ? ? A THR 237 O ? ? ? 1_555 EA K . K ? ? U THR 237 A K 415 1_555 ? ? ? ? ? ? ? 3.030 ? ? 
metalc7  metalc ? ? A THR 237 O ? ? ? 1_555 FA K . K ? ? U THR 237 A K 416 1_555 ? ? ? ? ? ? ? 3.005 ? ? 
metalc8  metalc ? ? A ILE 238 O ? ? ? 1_555 EA K . K ? ? U ILE 238 A K 415 1_555 ? ? ? ? ? ? ? 3.083 ? ? 
metalc9  metalc ? ? A GLY 239 O ? ? ? 1_555 GA K . K ? ? U GLY 239 A K 417 1_555 ? ? ? ? ? ? ? 2.783 ? ? 
metalc10 metalc ? ? A PHE 240 O ? ? ? 1_555 GA K . K ? ? U PHE 240 A K 417 1_555 ? ? ? ? ? ? ? 3.463 ? ? 
metalc11 metalc ? ? B THR 110 O ? ? ? 1_555 EA K . K ? ? A THR 110 A K 415 1_555 ? ? ? ? ? ? ? 3.087 ? ? 
metalc12 metalc ? ? B THR 110 O ? ? ? 1_555 FA K . K ? ? A THR 110 A K 416 1_555 ? ? ? ? ? ? ? 2.873 ? ? 
metalc13 metalc ? ? B ILE 111 O ? ? ? 1_555 EA K . K ? ? A ILE 111 A K 415 1_555 ? ? ? ? ? ? ? 3.014 ? ? 
metalc14 metalc ? ? B GLY 112 O ? ? ? 1_555 GA K . K ? ? A GLY 112 A K 417 1_555 ? ? ? ? ? ? ? 3.036 ? ? 
metalc15 metalc ? ? B PHE 113 O ? ? ? 1_555 GA K . K ? ? A PHE 113 A K 417 1_555 ? ? ? ? ? ? ? 3.342 ? ? 
metalc16 metalc ? ? B THR 237 O ? ? ? 1_555 EA K . K ? ? A THR 237 A K 415 1_555 ? ? ? ? ? ? ? 3.036 ? ? 
metalc17 metalc ? ? B THR 237 O ? ? ? 1_555 FA K . K ? ? A THR 237 A K 416 1_555 ? ? ? ? ? ? ? 3.006 ? ? 
metalc18 metalc ? ? B ILE 238 O ? ? ? 1_555 EA K . K ? ? A ILE 238 A K 415 1_555 ? ? ? ? ? ? ? 3.092 ? ? 
metalc19 metalc ? ? B GLY 239 O ? ? ? 1_555 GA K . K ? ? A GLY 239 A K 417 1_555 ? ? ? ? ? ? ? 2.802 ? ? 
metalc20 metalc ? ? B PHE 240 O ? ? ? 1_555 GA K . K ? ? A PHE 240 A K 417 1_555 ? ? ? ? ? ? ? 3.428 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  O ? A THR 110 ? U THR 110 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? A ILE 111 ? U ILE 111 ? 1_555 74.0  ? 
2  O ? A THR 110 ? U THR 110 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? A THR 237 ? U THR 237 ? 1_555 68.1  ? 
3  O ? A ILE 111 ? U ILE 111 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? A THR 237 ? U THR 237 ? 1_555 97.5  ? 
4  O ? A THR 110 ? U THR 110 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? A ILE 238 ? U ILE 238 ? 1_555 122.9 ? 
5  O ? A ILE 111 ? U ILE 111 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? A ILE 238 ? U ILE 238 ? 1_555 72.7  ? 
6  O ? A THR 237 ? U THR 237 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? A ILE 238 ? U ILE 238 ? 1_555 71.9  ? 
7  O ? A THR 110 ? U THR 110 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? B THR 110 ? A THR 110 ? 1_555 104.8 ? 
8  O ? A ILE 111 ? U ILE 111 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? B THR 110 ? A THR 110 ? 1_555 171.4 ? 
9  O ? A THR 237 ? U THR 237 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? B THR 110 ? A THR 110 ? 1_555 74.4  ? 
10 O ? A ILE 238 ? U ILE 238 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? B THR 110 ? A THR 110 ? 1_555 101.5 ? 
11 O ? A THR 110 ? U THR 110 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? B ILE 111 ? A ILE 111 ? 1_555 166.8 ? 
12 O ? A ILE 111 ? U ILE 111 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? B ILE 111 ? A ILE 111 ? 1_555 109.4 ? 
13 O ? A THR 237 ? U THR 237 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? B ILE 111 ? A ILE 111 ? 1_555 122.8 ? 
14 O ? A ILE 238 ? U ILE 238 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? B ILE 111 ? A ILE 111 ? 1_555 69.8  ? 
15 O ? B THR 110 ? A THR 110 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? B ILE 111 ? A ILE 111 ? 1_555 73.7  ? 
16 O ? A THR 110 ? U THR 110 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? B THR 237 ? A THR 237 ? 1_555 71.7  ? 
17 O ? A ILE 111 ? U ILE 111 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? B THR 237 ? A THR 237 ? 1_555 120.6 ? 
18 O ? A THR 237 ? U THR 237 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? B THR 237 ? A THR 237 ? 1_555 112.2 ? 
19 O ? A ILE 238 ? U ILE 238 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? B THR 237 ? A THR 237 ? 1_555 164.0 ? 
20 O ? B THR 110 ? A THR 110 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? B THR 237 ? A THR 237 ? 1_555 66.2  ? 
21 O ? B ILE 111 ? A ILE 111 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? B THR 237 ? A THR 237 ? 1_555 96.1  ? 
22 O ? A THR 110 ? U THR 110 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 99.6  ? 
23 O ? A ILE 111 ? U ILE 111 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 68.6  ? 
24 O ? A THR 237 ? U THR 237 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 164.1 ? 
25 O ? A ILE 238 ? U ILE 238 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 109.4 ? 
26 O ? B THR 110 ? A THR 110 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 119.9 ? 
27 O ? B ILE 111 ? A ILE 111 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 70.9  ? 
28 O ? B THR 237 ? A THR 237 ? 1_555 K ? EA K . ? A K 415 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 71.2  ? 
29 O ? A THR 110 ? U THR 110 ? 1_555 K ? FA K . ? A K 416 ? 1_555 O ? A THR 237 ? U THR 237 ? 1_555 72.6  ? 
30 O ? A THR 110 ? U THR 110 ? 1_555 K ? FA K . ? A K 416 ? 1_555 O ? B THR 110 ? A THR 110 ? 1_555 119.8 ? 
31 O ? A THR 237 ? U THR 237 ? 1_555 K ? FA K . ? A K 416 ? 1_555 O ? B THR 110 ? A THR 110 ? 1_555 77.9  ? 
32 O ? A THR 110 ? U THR 110 ? 1_555 K ? FA K . ? A K 416 ? 1_555 O ? B THR 237 ? A THR 237 ? 1_555 76.5  ? 
33 O ? A THR 237 ? U THR 237 ? 1_555 K ? FA K . ? A K 416 ? 1_555 O ? B THR 237 ? A THR 237 ? 1_555 113.8 ? 
34 O ? B THR 110 ? A THR 110 ? 1_555 K ? FA K . ? A K 416 ? 1_555 O ? B THR 237 ? A THR 237 ? 1_555 69.3  ? 
35 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? A PHE 113 ? U PHE 113 ? 1_555 67.3  ? 
36 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? A GLY 239 ? U GLY 239 ? 1_555 78.9  ? 
37 O ? A PHE 113 ? U PHE 113 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? A GLY 239 ? U GLY 239 ? 1_555 88.9  ? 
38 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? A PHE 240 ? U PHE 240 ? 1_555 123.0 ? 
39 O ? A PHE 113 ? U PHE 113 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? A PHE 240 ? U PHE 240 ? 1_555 70.1  ? 
40 O ? A GLY 239 ? U GLY 239 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? A PHE 240 ? U PHE 240 ? 1_555 64.2  ? 
41 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? B GLY 112 ? A GLY 112 ? 1_555 128.9 ? 
42 O ? A PHE 113 ? U PHE 113 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? B GLY 112 ? A GLY 112 ? 1_555 147.6 ? 
43 O ? A GLY 239 ? U GLY 239 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? B GLY 112 ? A GLY 112 ? 1_555 70.5  ? 
44 O ? A PHE 240 ? U PHE 240 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? B GLY 112 ? A GLY 112 ? 1_555 78.3  ? 
45 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? B PHE 113 ? A PHE 113 ? 1_555 159.0 ? 
46 O ? A PHE 113 ? U PHE 113 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? B PHE 113 ? A PHE 113 ? 1_555 116.5 ? 
47 O ? A GLY 239 ? U GLY 239 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? B PHE 113 ? A PHE 113 ? 1_555 120.9 ? 
48 O ? A PHE 240 ? U PHE 240 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? B PHE 113 ? A PHE 113 ? 1_555 75.6  ? 
49 O ? B GLY 112 ? A GLY 112 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? B PHE 113 ? A PHE 113 ? 1_555 60.0  ? 
50 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 76.3  ? 
51 O ? A PHE 113 ? U PHE 113 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 123.6 ? 
52 O ? A GLY 239 ? U GLY 239 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 125.0 ? 
53 O ? A PHE 240 ? U PHE 240 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 160.6 ? 
54 O ? B GLY 112 ? A GLY 112 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 88.8  ? 
55 O ? B PHE 113 ? A PHE 113 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 85.5  ? 
56 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? B PHE 240 ? A PHE 240 ? 1_555 93.1  ? 
57 O ? A PHE 113 ? U PHE 113 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? B PHE 240 ? A PHE 240 ? 1_555 75.8  ? 
58 O ? A GLY 239 ? U GLY 239 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? B PHE 240 ? A PHE 240 ? 1_555 164.5 ? 
59 O ? A PHE 240 ? U PHE 240 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? B PHE 240 ? A PHE 240 ? 1_555 111.1 ? 
60 O ? B GLY 112 ? A GLY 112 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? B PHE 240 ? A PHE 240 ? 1_555 124.1 ? 
61 O ? B PHE 113 ? A PHE 113 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? B PHE 240 ? A PHE 240 ? 1_555 69.2  ? 
62 O ? B GLY 239 ? A GLY 239 ? 1_555 K ? GA K . ? A K 417 ? 1_555 O ? B PHE 240 ? A PHE 240 ? 1_555 64.6  ? 
# 
_pdbx_entry_details.entry_id                   9BYI 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ILE U 111 ? ? -90.85  -61.06  
2  1 TYR U 216 ? ? 72.05   -13.46  
3  1 ALA U 249 ? ? 69.21   -6.22   
4  1 GLU U 252 ? ? 46.95   -114.45 
5  1 GLN U 254 ? ? 55.05   17.61   
6  1 ALA A 84  ? ? -79.08  -169.42 
7  1 ARG A 87  ? ? -127.41 -169.49 
8  1 ASP A 89  ? ? -107.26 55.67   
9  1 ASP A 96  ? ? -95.01  -73.11  
10 1 PHE A 97  ? ? -139.77 -38.73  
11 1 TYR A 216 ? ? 72.24   -12.67  
12 1 ALA A 249 ? ? 69.36   -5.91   
13 1 GLU A 252 ? ? 47.56   -117.71 
14 1 GLN A 254 ? ? 67.92   -5.63   
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9BYI 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9BYI 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  2.95 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               375069 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.8 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Human K2P13.1 in detergent' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        9BYI 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           'FEI TITAN KRIOS AUTOGRID HOLDER' 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_vitrification.entry_id              9BYI 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              100 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   277.15 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9BYI 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 U MET 1   ? A MET 1   
2   1 Y 1 U ALA 2   ? A ALA 2   
3   1 Y 1 U GLY 3   ? A GLY 3   
4   1 Y 1 U ARG 4   ? A ARG 4   
5   1 Y 1 U GLY 5   ? A GLY 5   
6   1 Y 1 U PHE 6   ? A PHE 6   
7   1 Y 1 U SER 7   ? A SER 7   
8   1 Y 1 U TRP 8   ? A TRP 8   
9   1 Y 1 U GLY 9   ? A GLY 9   
10  1 Y 1 U PRO 10  ? A PRO 10  
11  1 Y 1 U GLY 11  ? A GLY 11  
12  1 Y 1 U HIS 12  ? A HIS 12  
13  1 Y 1 U LEU 13  ? A LEU 13  
14  1 Y 1 U ARG 168 ? A ARG 168 
15  1 Y 1 U GLY 169 ? A GLY 169 
16  1 Y 1 U ALA 170 ? A ALA 170 
17  1 Y 1 U LEU 171 ? A LEU 171 
18  1 Y 1 U PRO 172 ? A PRO 172 
19  1 Y 1 U GLN 173 ? A GLN 173 
20  1 Y 1 U GLU 174 ? A GLU 174 
21  1 Y 1 U SER 175 ? A SER 175 
22  1 Y 1 U LEU 176 ? A LEU 176 
23  1 Y 1 U LYS 177 ? A LYS 177 
24  1 Y 1 U ASP 178 ? A ASP 178 
25  1 Y 1 U ALA 179 ? A ALA 179 
26  1 Y 1 U GLY 180 ? A GLY 180 
27  1 Y 1 U GLN 181 ? A GLN 181 
28  1 Y 1 U CYS 182 ? A CYS 182 
29  1 Y 1 U GLU 183 ? A GLU 183 
30  1 Y 1 U VAL 184 ? A VAL 184 
31  1 Y 1 U ASP 185 ? A ASP 185 
32  1 Y 1 U SER 186 ? A SER 186 
33  1 Y 1 U LEU 187 ? A LEU 187 
34  1 Y 1 U SER 296 ? A SER 296 
35  1 Y 1 U GLY 297 ? A GLY 297 
36  1 Y 1 U CYS 298 ? A CYS 298 
37  1 Y 1 U CYS 299 ? A CYS 299 
38  1 Y 1 U PRO 300 ? A PRO 300 
39  1 Y 1 U GLN 301 ? A GLN 301 
40  1 Y 1 U CYS 302 ? A CYS 302 
41  1 Y 1 U GLN 303 ? A GLN 303 
42  1 Y 1 U ARG 304 ? A ARG 304 
43  1 Y 1 U GLY 305 ? A GLY 305 
44  1 Y 1 U LEU 306 ? A LEU 306 
45  1 Y 1 U LEU 307 ? A LEU 307 
46  1 Y 1 U ARG 308 ? A ARG 308 
47  1 Y 1 U SER 309 ? A SER 309 
48  1 Y 1 U ARG 310 ? A ARG 310 
49  1 Y 1 U ARG 311 ? A ARG 311 
50  1 Y 1 U ASN 312 ? A ASN 312 
51  1 Y 1 U VAL 313 ? A VAL 313 
52  1 Y 1 U VAL 314 ? A VAL 314 
53  1 Y 1 U MET 315 ? A MET 315 
54  1 Y 1 U PRO 316 ? A PRO 316 
55  1 Y 1 U GLY 317 ? A GLY 317 
56  1 Y 1 U SER 318 ? A SER 318 
57  1 Y 1 U VAL 319 ? A VAL 319 
58  1 Y 1 U ARG 320 ? A ARG 320 
59  1 Y 1 U ASN 321 ? A ASN 321 
60  1 Y 1 U ARG 322 ? A ARG 322 
61  1 Y 1 U CYS 323 ? A CYS 323 
62  1 Y 1 U ASN 324 ? A ASN 324 
63  1 Y 1 U ILE 325 ? A ILE 325 
64  1 Y 1 U SER 326 ? A SER 326 
65  1 Y 1 U ILE 327 ? A ILE 327 
66  1 Y 1 U GLU 328 ? A GLU 328 
67  1 Y 1 U THR 329 ? A THR 329 
68  1 Y 1 U ASP 330 ? A ASP 330 
69  1 Y 1 U GLY 331 ? A GLY 331 
70  1 Y 1 U VAL 332 ? A VAL 332 
71  1 Y 1 U ALA 333 ? A ALA 333 
72  1 Y 1 U GLU 334 ? A GLU 334 
73  1 Y 1 U SER 335 ? A SER 335 
74  1 Y 1 U ASP 336 ? A ASP 336 
75  1 Y 1 U THR 337 ? A THR 337 
76  1 Y 1 U ASP 338 ? A ASP 338 
77  1 Y 1 U GLY 339 ? A GLY 339 
78  1 Y 1 U ARG 340 ? A ARG 340 
79  1 Y 1 U ARG 341 ? A ARG 341 
80  1 Y 1 U LEU 342 ? A LEU 342 
81  1 Y 1 U SER 343 ? A SER 343 
82  1 Y 1 U GLY 344 ? A GLY 344 
83  1 Y 1 U GLU 345 ? A GLU 345 
84  1 Y 1 U MET 346 ? A MET 346 
85  1 Y 1 U ILE 347 ? A ILE 347 
86  1 Y 1 U SER 348 ? A SER 348 
87  1 Y 1 U MET 349 ? A MET 349 
88  1 Y 1 U LYS 350 ? A LYS 350 
89  1 Y 1 A MET 1   ? B MET 1   
90  1 Y 1 A ALA 2   ? B ALA 2   
91  1 Y 1 A GLY 3   ? B GLY 3   
92  1 Y 1 A ARG 4   ? B ARG 4   
93  1 Y 1 A GLY 5   ? B GLY 5   
94  1 Y 1 A PHE 6   ? B PHE 6   
95  1 Y 1 A SER 7   ? B SER 7   
96  1 Y 1 A TRP 8   ? B TRP 8   
97  1 Y 1 A GLY 9   ? B GLY 9   
98  1 Y 1 A PRO 10  ? B PRO 10  
99  1 Y 1 A GLY 11  ? B GLY 11  
100 1 Y 1 A HIS 12  ? B HIS 12  
101 1 Y 1 A LEU 13  ? B LEU 13  
102 1 Y 1 A ARG 168 ? B ARG 168 
103 1 Y 1 A GLY 169 ? B GLY 169 
104 1 Y 1 A ALA 170 ? B ALA 170 
105 1 Y 1 A LEU 171 ? B LEU 171 
106 1 Y 1 A PRO 172 ? B PRO 172 
107 1 Y 1 A GLN 173 ? B GLN 173 
108 1 Y 1 A GLU 174 ? B GLU 174 
109 1 Y 1 A SER 175 ? B SER 175 
110 1 Y 1 A LEU 176 ? B LEU 176 
111 1 Y 1 A LYS 177 ? B LYS 177 
112 1 Y 1 A ASP 178 ? B ASP 178 
113 1 Y 1 A ALA 179 ? B ALA 179 
114 1 Y 1 A GLY 180 ? B GLY 180 
115 1 Y 1 A GLN 181 ? B GLN 181 
116 1 Y 1 A CYS 182 ? B CYS 182 
117 1 Y 1 A GLU 183 ? B GLU 183 
118 1 Y 1 A VAL 184 ? B VAL 184 
119 1 Y 1 A ASP 185 ? B ASP 185 
120 1 Y 1 A SER 186 ? B SER 186 
121 1 Y 1 A LEU 187 ? B LEU 187 
122 1 Y 1 A SER 296 ? B SER 296 
123 1 Y 1 A GLY 297 ? B GLY 297 
124 1 Y 1 A CYS 298 ? B CYS 298 
125 1 Y 1 A CYS 299 ? B CYS 299 
126 1 Y 1 A PRO 300 ? B PRO 300 
127 1 Y 1 A GLN 301 ? B GLN 301 
128 1 Y 1 A CYS 302 ? B CYS 302 
129 1 Y 1 A GLN 303 ? B GLN 303 
130 1 Y 1 A ARG 304 ? B ARG 304 
131 1 Y 1 A GLY 305 ? B GLY 305 
132 1 Y 1 A LEU 306 ? B LEU 306 
133 1 Y 1 A LEU 307 ? B LEU 307 
134 1 Y 1 A ARG 308 ? B ARG 308 
135 1 Y 1 A SER 309 ? B SER 309 
136 1 Y 1 A ARG 310 ? B ARG 310 
137 1 Y 1 A ARG 311 ? B ARG 311 
138 1 Y 1 A ASN 312 ? B ASN 312 
139 1 Y 1 A VAL 313 ? B VAL 313 
140 1 Y 1 A VAL 314 ? B VAL 314 
141 1 Y 1 A MET 315 ? B MET 315 
142 1 Y 1 A PRO 316 ? B PRO 316 
143 1 Y 1 A GLY 317 ? B GLY 317 
144 1 Y 1 A SER 318 ? B SER 318 
145 1 Y 1 A VAL 319 ? B VAL 319 
146 1 Y 1 A ARG 320 ? B ARG 320 
147 1 Y 1 A ASN 321 ? B ASN 321 
148 1 Y 1 A ARG 322 ? B ARG 322 
149 1 Y 1 A CYS 323 ? B CYS 323 
150 1 Y 1 A ASN 324 ? B ASN 324 
151 1 Y 1 A ILE 325 ? B ILE 325 
152 1 Y 1 A SER 326 ? B SER 326 
153 1 Y 1 A ILE 327 ? B ILE 327 
154 1 Y 1 A GLU 328 ? B GLU 328 
155 1 Y 1 A THR 329 ? B THR 329 
156 1 Y 1 A ASP 330 ? B ASP 330 
157 1 Y 1 A GLY 331 ? B GLY 331 
158 1 Y 1 A VAL 332 ? B VAL 332 
159 1 Y 1 A ALA 333 ? B ALA 333 
160 1 Y 1 A GLU 334 ? B GLU 334 
161 1 Y 1 A SER 335 ? B SER 335 
162 1 Y 1 A ASP 336 ? B ASP 336 
163 1 Y 1 A THR 337 ? B THR 337 
164 1 Y 1 A ASP 338 ? B ASP 338 
165 1 Y 1 A GLY 339 ? B GLY 339 
166 1 Y 1 A ARG 340 ? B ARG 340 
167 1 Y 1 A ARG 341 ? B ARG 341 
168 1 Y 1 A LEU 342 ? B LEU 342 
169 1 Y 1 A SER 343 ? B SER 343 
170 1 Y 1 A GLY 344 ? B GLY 344 
171 1 Y 1 A GLU 345 ? B GLU 345 
172 1 Y 1 A MET 346 ? B MET 346 
173 1 Y 1 A ILE 347 ? B ILE 347 
174 1 Y 1 A SER 348 ? B SER 348 
175 1 Y 1 A MET 349 ? B MET 349 
176 1 Y 1 A LYS 350 ? B LYS 350 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
D12 C1   C N N 88  
D12 C2   C N N 89  
D12 C3   C N N 90  
D12 C4   C N N 91  
D12 C5   C N N 92  
D12 C6   C N N 93  
D12 C7   C N N 94  
D12 C8   C N N 95  
D12 C9   C N N 96  
D12 C10  C N N 97  
D12 C11  C N N 98  
D12 C12  C N N 99  
D12 H11  H N N 100 
D12 H12  H N N 101 
D12 H13  H N N 102 
D12 H21  H N N 103 
D12 H22  H N N 104 
D12 H31  H N N 105 
D12 H32  H N N 106 
D12 H41  H N N 107 
D12 H42  H N N 108 
D12 H51  H N N 109 
D12 H52  H N N 110 
D12 H61  H N N 111 
D12 H62  H N N 112 
D12 H71  H N N 113 
D12 H72  H N N 114 
D12 H81  H N N 115 
D12 H82  H N N 116 
D12 H91  H N N 117 
D12 H92  H N N 118 
D12 H101 H N N 119 
D12 H102 H N N 120 
D12 H111 H N N 121 
D12 H112 H N N 122 
D12 H121 H N N 123 
D12 H122 H N N 124 
D12 H123 H N N 125 
EIC C1   C N N 126 
EIC C2   C N N 127 
EIC C3   C N N 128 
EIC C4   C N N 129 
EIC C5   C N N 130 
EIC C6   C N N 131 
EIC C7   C N N 132 
EIC C8   C N N 133 
EIC C9   C N N 134 
EIC C10  C N N 135 
EIC C11  C N N 136 
EIC C12  C N N 137 
EIC C13  C N N 138 
EIC C14  C N N 139 
EIC C15  C N N 140 
EIC C16  C N N 141 
EIC C17  C N N 142 
EIC C18  C N N 143 
EIC O1   O N N 144 
EIC O2   O N N 145 
EIC H21  H N N 146 
EIC H22  H N N 147 
EIC H31  H N N 148 
EIC H32  H N N 149 
EIC H41  H N N 150 
EIC H42  H N N 151 
EIC H51  H N N 152 
EIC H52  H N N 153 
EIC H61  H N N 154 
EIC H62  H N N 155 
EIC H71  H N N 156 
EIC H72  H N N 157 
EIC H81  H N N 158 
EIC H82  H N N 159 
EIC H91  H N N 160 
EIC H1O1 H N N 161 
EIC H111 H N N 162 
EIC H112 H N N 163 
EIC H121 H N N 164 
EIC H131 H N N 165 
EIC H141 H N N 166 
EIC H142 H N N 167 
EIC H151 H N N 168 
EIC H152 H N N 169 
EIC H161 H N N 170 
EIC H162 H N N 171 
EIC H171 H N N 172 
EIC H172 H N N 173 
EIC H181 H N N 174 
EIC H182 H N N 175 
EIC H183 H N N 176 
EIC HO2  H N N 177 
GLN N    N N N 178 
GLN CA   C N S 179 
GLN C    C N N 180 
GLN O    O N N 181 
GLN CB   C N N 182 
GLN CG   C N N 183 
GLN CD   C N N 184 
GLN OE1  O N N 185 
GLN NE2  N N N 186 
GLN OXT  O N N 187 
GLN H    H N N 188 
GLN H2   H N N 189 
GLN HA   H N N 190 
GLN HB2  H N N 191 
GLN HB3  H N N 192 
GLN HG2  H N N 193 
GLN HG3  H N N 194 
GLN HE21 H N N 195 
GLN HE22 H N N 196 
GLN HXT  H N N 197 
GLU N    N N N 198 
GLU CA   C N S 199 
GLU C    C N N 200 
GLU O    O N N 201 
GLU CB   C N N 202 
GLU CG   C N N 203 
GLU CD   C N N 204 
GLU OE1  O N N 205 
GLU OE2  O N N 206 
GLU OXT  O N N 207 
GLU H    H N N 208 
GLU H2   H N N 209 
GLU HA   H N N 210 
GLU HB2  H N N 211 
GLU HB3  H N N 212 
GLU HG2  H N N 213 
GLU HG3  H N N 214 
GLU HE2  H N N 215 
GLU HXT  H N N 216 
GLY N    N N N 217 
GLY CA   C N N 218 
GLY C    C N N 219 
GLY O    O N N 220 
GLY OXT  O N N 221 
GLY H    H N N 222 
GLY H2   H N N 223 
GLY HA2  H N N 224 
GLY HA3  H N N 225 
GLY HXT  H N N 226 
HEX C1   C N N 227 
HEX C2   C N N 228 
HEX C3   C N N 229 
HEX C4   C N N 230 
HEX C5   C N N 231 
HEX C6   C N N 232 
HEX H11  H N N 233 
HEX H12  H N N 234 
HEX H13  H N N 235 
HEX H21  H N N 236 
HEX H22  H N N 237 
HEX H31  H N N 238 
HEX H32  H N N 239 
HEX H41  H N N 240 
HEX H42  H N N 241 
HEX H51  H N N 242 
HEX H52  H N N 243 
HEX H61  H N N 244 
HEX H62  H N N 245 
HEX H63  H N N 246 
HIS N    N N N 247 
HIS CA   C N S 248 
HIS C    C N N 249 
HIS O    O N N 250 
HIS CB   C N N 251 
HIS CG   C Y N 252 
HIS ND1  N Y N 253 
HIS CD2  C Y N 254 
HIS CE1  C Y N 255 
HIS NE2  N Y N 256 
HIS OXT  O N N 257 
HIS H    H N N 258 
HIS H2   H N N 259 
HIS HA   H N N 260 
HIS HB2  H N N 261 
HIS HB3  H N N 262 
HIS HD1  H N N 263 
HIS HD2  H N N 264 
HIS HE1  H N N 265 
HIS HE2  H N N 266 
HIS HXT  H N N 267 
ILE N    N N N 268 
ILE CA   C N S 269 
ILE C    C N N 270 
ILE O    O N N 271 
ILE CB   C N S 272 
ILE CG1  C N N 273 
ILE CG2  C N N 274 
ILE CD1  C N N 275 
ILE OXT  O N N 276 
ILE H    H N N 277 
ILE H2   H N N 278 
ILE HA   H N N 279 
ILE HB   H N N 280 
ILE HG12 H N N 281 
ILE HG13 H N N 282 
ILE HG21 H N N 283 
ILE HG22 H N N 284 
ILE HG23 H N N 285 
ILE HD11 H N N 286 
ILE HD12 H N N 287 
ILE HD13 H N N 288 
ILE HXT  H N N 289 
K   K    K N N 290 
LEU N    N N N 291 
LEU CA   C N S 292 
LEU C    C N N 293 
LEU O    O N N 294 
LEU CB   C N N 295 
LEU CG   C N N 296 
LEU CD1  C N N 297 
LEU CD2  C N N 298 
LEU OXT  O N N 299 
LEU H    H N N 300 
LEU H2   H N N 301 
LEU HA   H N N 302 
LEU HB2  H N N 303 
LEU HB3  H N N 304 
LEU HG   H N N 305 
LEU HD11 H N N 306 
LEU HD12 H N N 307 
LEU HD13 H N N 308 
LEU HD21 H N N 309 
LEU HD22 H N N 310 
LEU HD23 H N N 311 
LEU HXT  H N N 312 
LYS N    N N N 313 
LYS CA   C N S 314 
LYS C    C N N 315 
LYS O    O N N 316 
LYS CB   C N N 317 
LYS CG   C N N 318 
LYS CD   C N N 319 
LYS CE   C N N 320 
LYS NZ   N N N 321 
LYS OXT  O N N 322 
LYS H    H N N 323 
LYS H2   H N N 324 
LYS HA   H N N 325 
LYS HB2  H N N 326 
LYS HB3  H N N 327 
LYS HG2  H N N 328 
LYS HG3  H N N 329 
LYS HD2  H N N 330 
LYS HD3  H N N 331 
LYS HE2  H N N 332 
LYS HE3  H N N 333 
LYS HZ1  H N N 334 
LYS HZ2  H N N 335 
LYS HZ3  H N N 336 
LYS HXT  H N N 337 
MET N    N N N 338 
MET CA   C N S 339 
MET C    C N N 340 
MET O    O N N 341 
MET CB   C N N 342 
MET CG   C N N 343 
MET SD   S N N 344 
MET CE   C N N 345 
MET OXT  O N N 346 
MET H    H N N 347 
MET H2   H N N 348 
MET HA   H N N 349 
MET HB2  H N N 350 
MET HB3  H N N 351 
MET HG2  H N N 352 
MET HG3  H N N 353 
MET HE1  H N N 354 
MET HE2  H N N 355 
MET HE3  H N N 356 
MET HXT  H N N 357 
OCT C1   C N N 358 
OCT C2   C N N 359 
OCT C3   C N N 360 
OCT C4   C N N 361 
OCT C5   C N N 362 
OCT C6   C N N 363 
OCT C7   C N N 364 
OCT C8   C N N 365 
OCT H11  H N N 366 
OCT H12  H N N 367 
OCT H13  H N N 368 
OCT H21  H N N 369 
OCT H22  H N N 370 
OCT H31  H N N 371 
OCT H32  H N N 372 
OCT H41  H N N 373 
OCT H42  H N N 374 
OCT H51  H N N 375 
OCT H52  H N N 376 
OCT H61  H N N 377 
OCT H62  H N N 378 
OCT H71  H N N 379 
OCT H72  H N N 380 
OCT H81  H N N 381 
OCT H82  H N N 382 
OCT H83  H N N 383 
PHE N    N N N 384 
PHE CA   C N S 385 
PHE C    C N N 386 
PHE O    O N N 387 
PHE CB   C N N 388 
PHE CG   C Y N 389 
PHE CD1  C Y N 390 
PHE CD2  C Y N 391 
PHE CE1  C Y N 392 
PHE CE2  C Y N 393 
PHE CZ   C Y N 394 
PHE OXT  O N N 395 
PHE H    H N N 396 
PHE H2   H N N 397 
PHE HA   H N N 398 
PHE HB2  H N N 399 
PHE HB3  H N N 400 
PHE HD1  H N N 401 
PHE HD2  H N N 402 
PHE HE1  H N N 403 
PHE HE2  H N N 404 
PHE HZ   H N N 405 
PHE HXT  H N N 406 
PRO N    N N N 407 
PRO CA   C N S 408 
PRO C    C N N 409 
PRO O    O N N 410 
PRO CB   C N N 411 
PRO CG   C N N 412 
PRO CD   C N N 413 
PRO OXT  O N N 414 
PRO H    H N N 415 
PRO HA   H N N 416 
PRO HB2  H N N 417 
PRO HB3  H N N 418 
PRO HG2  H N N 419 
PRO HG3  H N N 420 
PRO HD2  H N N 421 
PRO HD3  H N N 422 
PRO HXT  H N N 423 
R16 C27  C N N 424 
R16 C28  C N N 425 
R16 C29  C N N 426 
R16 C30  C N N 427 
R16 C31  C N N 428 
R16 C32  C N N 429 
R16 C33  C N N 430 
R16 C34  C N N 431 
R16 C35  C N N 432 
R16 C36  C N N 433 
R16 C37  C N N 434 
R16 C38  C N N 435 
R16 C39  C N N 436 
R16 C40  C N N 437 
R16 C41  C N N 438 
R16 C42  C N N 439 
R16 H271 H N N 440 
R16 H272 H N N 441 
R16 H273 H N N 442 
R16 H281 H N N 443 
R16 H282 H N N 444 
R16 H291 H N N 445 
R16 H292 H N N 446 
R16 H301 H N N 447 
R16 H302 H N N 448 
R16 H311 H N N 449 
R16 H312 H N N 450 
R16 H321 H N N 451 
R16 H322 H N N 452 
R16 H331 H N N 453 
R16 H332 H N N 454 
R16 H341 H N N 455 
R16 H342 H N N 456 
R16 H351 H N N 457 
R16 H352 H N N 458 
R16 H361 H N N 459 
R16 H362 H N N 460 
R16 H371 H N N 461 
R16 H372 H N N 462 
R16 H381 H N N 463 
R16 H382 H N N 464 
R16 H391 H N N 465 
R16 H392 H N N 466 
R16 H401 H N N 467 
R16 H402 H N N 468 
R16 H411 H N N 469 
R16 H412 H N N 470 
R16 H421 H N N 471 
R16 H422 H N N 472 
R16 H423 H N N 473 
SER N    N N N 474 
SER CA   C N S 475 
SER C    C N N 476 
SER O    O N N 477 
SER CB   C N N 478 
SER OG   O N N 479 
SER OXT  O N N 480 
SER H    H N N 481 
SER H2   H N N 482 
SER HA   H N N 483 
SER HB2  H N N 484 
SER HB3  H N N 485 
SER HG   H N N 486 
SER HXT  H N N 487 
THR N    N N N 488 
THR CA   C N S 489 
THR C    C N N 490 
THR O    O N N 491 
THR CB   C N R 492 
THR OG1  O N N 493 
THR CG2  C N N 494 
THR OXT  O N N 495 
THR H    H N N 496 
THR H2   H N N 497 
THR HA   H N N 498 
THR HB   H N N 499 
THR HG1  H N N 500 
THR HG21 H N N 501 
THR HG22 H N N 502 
THR HG23 H N N 503 
THR HXT  H N N 504 
TRP N    N N N 505 
TRP CA   C N S 506 
TRP C    C N N 507 
TRP O    O N N 508 
TRP CB   C N N 509 
TRP CG   C Y N 510 
TRP CD1  C Y N 511 
TRP CD2  C Y N 512 
TRP NE1  N Y N 513 
TRP CE2  C Y N 514 
TRP CE3  C Y N 515 
TRP CZ2  C Y N 516 
TRP CZ3  C Y N 517 
TRP CH2  C Y N 518 
TRP OXT  O N N 519 
TRP H    H N N 520 
TRP H2   H N N 521 
TRP HA   H N N 522 
TRP HB2  H N N 523 
TRP HB3  H N N 524 
TRP HD1  H N N 525 
TRP HE1  H N N 526 
TRP HE3  H N N 527 
TRP HZ2  H N N 528 
TRP HZ3  H N N 529 
TRP HH2  H N N 530 
TRP HXT  H N N 531 
TYR N    N N N 532 
TYR CA   C N S 533 
TYR C    C N N 534 
TYR O    O N N 535 
TYR CB   C N N 536 
TYR CG   C Y N 537 
TYR CD1  C Y N 538 
TYR CD2  C Y N 539 
TYR CE1  C Y N 540 
TYR CE2  C Y N 541 
TYR CZ   C Y N 542 
TYR OH   O N N 543 
TYR OXT  O N N 544 
TYR H    H N N 545 
TYR H2   H N N 546 
TYR HA   H N N 547 
TYR HB2  H N N 548 
TYR HB3  H N N 549 
TYR HD1  H N N 550 
TYR HD2  H N N 551 
TYR HE1  H N N 552 
TYR HE2  H N N 553 
TYR HH   H N N 554 
TYR HXT  H N N 555 
VAL N    N N N 556 
VAL CA   C N S 557 
VAL C    C N N 558 
VAL O    O N N 559 
VAL CB   C N N 560 
VAL CG1  C N N 561 
VAL CG2  C N N 562 
VAL OXT  O N N 563 
VAL H    H N N 564 
VAL H2   H N N 565 
VAL HA   H N N 566 
VAL HB   H N N 567 
VAL HG11 H N N 568 
VAL HG12 H N N 569 
VAL HG13 H N N 570 
VAL HG21 H N N 571 
VAL HG22 H N N 572 
VAL HG23 H N N 573 
VAL HXT  H N N 574 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
D12 C1  C2   sing N N 83  
D12 C1  H11  sing N N 84  
D12 C1  H12  sing N N 85  
D12 C1  H13  sing N N 86  
D12 C2  C3   sing N N 87  
D12 C2  H21  sing N N 88  
D12 C2  H22  sing N N 89  
D12 C3  C4   sing N N 90  
D12 C3  H31  sing N N 91  
D12 C3  H32  sing N N 92  
D12 C4  C5   sing N N 93  
D12 C4  H41  sing N N 94  
D12 C4  H42  sing N N 95  
D12 C5  C6   sing N N 96  
D12 C5  H51  sing N N 97  
D12 C5  H52  sing N N 98  
D12 C6  C7   sing N N 99  
D12 C6  H61  sing N N 100 
D12 C6  H62  sing N N 101 
D12 C7  C8   sing N N 102 
D12 C7  H71  sing N N 103 
D12 C7  H72  sing N N 104 
D12 C8  C9   sing N N 105 
D12 C8  H81  sing N N 106 
D12 C8  H82  sing N N 107 
D12 C9  C10  sing N N 108 
D12 C9  H91  sing N N 109 
D12 C9  H92  sing N N 110 
D12 C10 C11  sing N N 111 
D12 C10 H101 sing N N 112 
D12 C10 H102 sing N N 113 
D12 C11 C12  sing N N 114 
D12 C11 H111 sing N N 115 
D12 C11 H112 sing N N 116 
D12 C12 H121 sing N N 117 
D12 C12 H122 sing N N 118 
D12 C12 H123 sing N N 119 
EIC C1  C2   sing N N 120 
EIC C1  O1   doub N N 121 
EIC C1  O2   sing N N 122 
EIC C2  C3   sing N N 123 
EIC C2  H21  sing N N 124 
EIC C2  H22  sing N N 125 
EIC C3  C4   sing N N 126 
EIC C3  H31  sing N N 127 
EIC C3  H32  sing N N 128 
EIC C4  C5   sing N N 129 
EIC C4  H41  sing N N 130 
EIC C4  H42  sing N N 131 
EIC C5  C6   sing N N 132 
EIC C5  H51  sing N N 133 
EIC C5  H52  sing N N 134 
EIC C6  C7   sing N N 135 
EIC C6  H61  sing N N 136 
EIC C6  H62  sing N N 137 
EIC C7  C8   sing N N 138 
EIC C7  H71  sing N N 139 
EIC C7  H72  sing N N 140 
EIC C8  C9   sing N N 141 
EIC C8  H81  sing N N 142 
EIC C8  H82  sing N N 143 
EIC C9  C10  doub N Z 144 
EIC C9  H91  sing N N 145 
EIC C10 C11  sing N N 146 
EIC C10 H1O1 sing N N 147 
EIC C11 C12  sing N N 148 
EIC C11 H111 sing N N 149 
EIC C11 H112 sing N N 150 
EIC C12 C13  doub N Z 151 
EIC C12 H121 sing N N 152 
EIC C13 C14  sing N N 153 
EIC C13 H131 sing N N 154 
EIC C14 C15  sing N N 155 
EIC C14 H141 sing N N 156 
EIC C14 H142 sing N N 157 
EIC C15 C16  sing N N 158 
EIC C15 H151 sing N N 159 
EIC C15 H152 sing N N 160 
EIC C16 C17  sing N N 161 
EIC C16 H161 sing N N 162 
EIC C16 H162 sing N N 163 
EIC C17 C18  sing N N 164 
EIC C17 H171 sing N N 165 
EIC C17 H172 sing N N 166 
EIC C18 H181 sing N N 167 
EIC C18 H182 sing N N 168 
EIC C18 H183 sing N N 169 
EIC O2  HO2  sing N N 170 
GLN N   CA   sing N N 171 
GLN N   H    sing N N 172 
GLN N   H2   sing N N 173 
GLN CA  C    sing N N 174 
GLN CA  CB   sing N N 175 
GLN CA  HA   sing N N 176 
GLN C   O    doub N N 177 
GLN C   OXT  sing N N 178 
GLN CB  CG   sing N N 179 
GLN CB  HB2  sing N N 180 
GLN CB  HB3  sing N N 181 
GLN CG  CD   sing N N 182 
GLN CG  HG2  sing N N 183 
GLN CG  HG3  sing N N 184 
GLN CD  OE1  doub N N 185 
GLN CD  NE2  sing N N 186 
GLN NE2 HE21 sing N N 187 
GLN NE2 HE22 sing N N 188 
GLN OXT HXT  sing N N 189 
GLU N   CA   sing N N 190 
GLU N   H    sing N N 191 
GLU N   H2   sing N N 192 
GLU CA  C    sing N N 193 
GLU CA  CB   sing N N 194 
GLU CA  HA   sing N N 195 
GLU C   O    doub N N 196 
GLU C   OXT  sing N N 197 
GLU CB  CG   sing N N 198 
GLU CB  HB2  sing N N 199 
GLU CB  HB3  sing N N 200 
GLU CG  CD   sing N N 201 
GLU CG  HG2  sing N N 202 
GLU CG  HG3  sing N N 203 
GLU CD  OE1  doub N N 204 
GLU CD  OE2  sing N N 205 
GLU OE2 HE2  sing N N 206 
GLU OXT HXT  sing N N 207 
GLY N   CA   sing N N 208 
GLY N   H    sing N N 209 
GLY N   H2   sing N N 210 
GLY CA  C    sing N N 211 
GLY CA  HA2  sing N N 212 
GLY CA  HA3  sing N N 213 
GLY C   O    doub N N 214 
GLY C   OXT  sing N N 215 
GLY OXT HXT  sing N N 216 
HEX C1  C2   sing N N 217 
HEX C1  H11  sing N N 218 
HEX C1  H12  sing N N 219 
HEX C1  H13  sing N N 220 
HEX C2  C3   sing N N 221 
HEX C2  H21  sing N N 222 
HEX C2  H22  sing N N 223 
HEX C3  C4   sing N N 224 
HEX C3  H31  sing N N 225 
HEX C3  H32  sing N N 226 
HEX C4  C5   sing N N 227 
HEX C4  H41  sing N N 228 
HEX C4  H42  sing N N 229 
HEX C5  C6   sing N N 230 
HEX C5  H51  sing N N 231 
HEX C5  H52  sing N N 232 
HEX C6  H61  sing N N 233 
HEX C6  H62  sing N N 234 
HEX C6  H63  sing N N 235 
HIS N   CA   sing N N 236 
HIS N   H    sing N N 237 
HIS N   H2   sing N N 238 
HIS CA  C    sing N N 239 
HIS CA  CB   sing N N 240 
HIS CA  HA   sing N N 241 
HIS C   O    doub N N 242 
HIS C   OXT  sing N N 243 
HIS CB  CG   sing N N 244 
HIS CB  HB2  sing N N 245 
HIS CB  HB3  sing N N 246 
HIS CG  ND1  sing Y N 247 
HIS CG  CD2  doub Y N 248 
HIS ND1 CE1  doub Y N 249 
HIS ND1 HD1  sing N N 250 
HIS CD2 NE2  sing Y N 251 
HIS CD2 HD2  sing N N 252 
HIS CE1 NE2  sing Y N 253 
HIS CE1 HE1  sing N N 254 
HIS NE2 HE2  sing N N 255 
HIS OXT HXT  sing N N 256 
ILE N   CA   sing N N 257 
ILE N   H    sing N N 258 
ILE N   H2   sing N N 259 
ILE CA  C    sing N N 260 
ILE CA  CB   sing N N 261 
ILE CA  HA   sing N N 262 
ILE C   O    doub N N 263 
ILE C   OXT  sing N N 264 
ILE CB  CG1  sing N N 265 
ILE CB  CG2  sing N N 266 
ILE CB  HB   sing N N 267 
ILE CG1 CD1  sing N N 268 
ILE CG1 HG12 sing N N 269 
ILE CG1 HG13 sing N N 270 
ILE CG2 HG21 sing N N 271 
ILE CG2 HG22 sing N N 272 
ILE CG2 HG23 sing N N 273 
ILE CD1 HD11 sing N N 274 
ILE CD1 HD12 sing N N 275 
ILE CD1 HD13 sing N N 276 
ILE OXT HXT  sing N N 277 
LEU N   CA   sing N N 278 
LEU N   H    sing N N 279 
LEU N   H2   sing N N 280 
LEU CA  C    sing N N 281 
LEU CA  CB   sing N N 282 
LEU CA  HA   sing N N 283 
LEU C   O    doub N N 284 
LEU C   OXT  sing N N 285 
LEU CB  CG   sing N N 286 
LEU CB  HB2  sing N N 287 
LEU CB  HB3  sing N N 288 
LEU CG  CD1  sing N N 289 
LEU CG  CD2  sing N N 290 
LEU CG  HG   sing N N 291 
LEU CD1 HD11 sing N N 292 
LEU CD1 HD12 sing N N 293 
LEU CD1 HD13 sing N N 294 
LEU CD2 HD21 sing N N 295 
LEU CD2 HD22 sing N N 296 
LEU CD2 HD23 sing N N 297 
LEU OXT HXT  sing N N 298 
LYS N   CA   sing N N 299 
LYS N   H    sing N N 300 
LYS N   H2   sing N N 301 
LYS CA  C    sing N N 302 
LYS CA  CB   sing N N 303 
LYS CA  HA   sing N N 304 
LYS C   O    doub N N 305 
LYS C   OXT  sing N N 306 
LYS CB  CG   sing N N 307 
LYS CB  HB2  sing N N 308 
LYS CB  HB3  sing N N 309 
LYS CG  CD   sing N N 310 
LYS CG  HG2  sing N N 311 
LYS CG  HG3  sing N N 312 
LYS CD  CE   sing N N 313 
LYS CD  HD2  sing N N 314 
LYS CD  HD3  sing N N 315 
LYS CE  NZ   sing N N 316 
LYS CE  HE2  sing N N 317 
LYS CE  HE3  sing N N 318 
LYS NZ  HZ1  sing N N 319 
LYS NZ  HZ2  sing N N 320 
LYS NZ  HZ3  sing N N 321 
LYS OXT HXT  sing N N 322 
MET N   CA   sing N N 323 
MET N   H    sing N N 324 
MET N   H2   sing N N 325 
MET CA  C    sing N N 326 
MET CA  CB   sing N N 327 
MET CA  HA   sing N N 328 
MET C   O    doub N N 329 
MET C   OXT  sing N N 330 
MET CB  CG   sing N N 331 
MET CB  HB2  sing N N 332 
MET CB  HB3  sing N N 333 
MET CG  SD   sing N N 334 
MET CG  HG2  sing N N 335 
MET CG  HG3  sing N N 336 
MET SD  CE   sing N N 337 
MET CE  HE1  sing N N 338 
MET CE  HE2  sing N N 339 
MET CE  HE3  sing N N 340 
MET OXT HXT  sing N N 341 
OCT C1  C2   sing N N 342 
OCT C1  H11  sing N N 343 
OCT C1  H12  sing N N 344 
OCT C1  H13  sing N N 345 
OCT C2  C3   sing N N 346 
OCT C2  H21  sing N N 347 
OCT C2  H22  sing N N 348 
OCT C3  C4   sing N N 349 
OCT C3  H31  sing N N 350 
OCT C3  H32  sing N N 351 
OCT C4  C5   sing N N 352 
OCT C4  H41  sing N N 353 
OCT C4  H42  sing N N 354 
OCT C5  C6   sing N N 355 
OCT C5  H51  sing N N 356 
OCT C5  H52  sing N N 357 
OCT C6  C7   sing N N 358 
OCT C6  H61  sing N N 359 
OCT C6  H62  sing N N 360 
OCT C7  C8   sing N N 361 
OCT C7  H71  sing N N 362 
OCT C7  H72  sing N N 363 
OCT C8  H81  sing N N 364 
OCT C8  H82  sing N N 365 
OCT C8  H83  sing N N 366 
PHE N   CA   sing N N 367 
PHE N   H    sing N N 368 
PHE N   H2   sing N N 369 
PHE CA  C    sing N N 370 
PHE CA  CB   sing N N 371 
PHE CA  HA   sing N N 372 
PHE C   O    doub N N 373 
PHE C   OXT  sing N N 374 
PHE CB  CG   sing N N 375 
PHE CB  HB2  sing N N 376 
PHE CB  HB3  sing N N 377 
PHE CG  CD1  doub Y N 378 
PHE CG  CD2  sing Y N 379 
PHE CD1 CE1  sing Y N 380 
PHE CD1 HD1  sing N N 381 
PHE CD2 CE2  doub Y N 382 
PHE CD2 HD2  sing N N 383 
PHE CE1 CZ   doub Y N 384 
PHE CE1 HE1  sing N N 385 
PHE CE2 CZ   sing Y N 386 
PHE CE2 HE2  sing N N 387 
PHE CZ  HZ   sing N N 388 
PHE OXT HXT  sing N N 389 
PRO N   CA   sing N N 390 
PRO N   CD   sing N N 391 
PRO N   H    sing N N 392 
PRO CA  C    sing N N 393 
PRO CA  CB   sing N N 394 
PRO CA  HA   sing N N 395 
PRO C   O    doub N N 396 
PRO C   OXT  sing N N 397 
PRO CB  CG   sing N N 398 
PRO CB  HB2  sing N N 399 
PRO CB  HB3  sing N N 400 
PRO CG  CD   sing N N 401 
PRO CG  HG2  sing N N 402 
PRO CG  HG3  sing N N 403 
PRO CD  HD2  sing N N 404 
PRO CD  HD3  sing N N 405 
PRO OXT HXT  sing N N 406 
R16 C27 C28  sing N N 407 
R16 C27 H271 sing N N 408 
R16 C27 H272 sing N N 409 
R16 C27 H273 sing N N 410 
R16 C28 C29  sing N N 411 
R16 C28 H281 sing N N 412 
R16 C28 H282 sing N N 413 
R16 C29 C30  sing N N 414 
R16 C29 H291 sing N N 415 
R16 C29 H292 sing N N 416 
R16 C30 C31  sing N N 417 
R16 C30 H301 sing N N 418 
R16 C30 H302 sing N N 419 
R16 C31 C32  sing N N 420 
R16 C31 H311 sing N N 421 
R16 C31 H312 sing N N 422 
R16 C32 C33  sing N N 423 
R16 C32 H321 sing N N 424 
R16 C32 H322 sing N N 425 
R16 C33 C34  sing N N 426 
R16 C33 H331 sing N N 427 
R16 C33 H332 sing N N 428 
R16 C34 C35  sing N N 429 
R16 C34 H341 sing N N 430 
R16 C34 H342 sing N N 431 
R16 C35 C36  sing N N 432 
R16 C35 H351 sing N N 433 
R16 C35 H352 sing N N 434 
R16 C36 C37  sing N N 435 
R16 C36 H361 sing N N 436 
R16 C36 H362 sing N N 437 
R16 C37 C38  sing N N 438 
R16 C37 H371 sing N N 439 
R16 C37 H372 sing N N 440 
R16 C38 C39  sing N N 441 
R16 C38 H381 sing N N 442 
R16 C38 H382 sing N N 443 
R16 C39 C40  sing N N 444 
R16 C39 H391 sing N N 445 
R16 C39 H392 sing N N 446 
R16 C40 C41  sing N N 447 
R16 C40 H401 sing N N 448 
R16 C40 H402 sing N N 449 
R16 C41 C42  sing N N 450 
R16 C41 H411 sing N N 451 
R16 C41 H412 sing N N 452 
R16 C42 H421 sing N N 453 
R16 C42 H422 sing N N 454 
R16 C42 H423 sing N N 455 
SER N   CA   sing N N 456 
SER N   H    sing N N 457 
SER N   H2   sing N N 458 
SER CA  C    sing N N 459 
SER CA  CB   sing N N 460 
SER CA  HA   sing N N 461 
SER C   O    doub N N 462 
SER C   OXT  sing N N 463 
SER CB  OG   sing N N 464 
SER CB  HB2  sing N N 465 
SER CB  HB3  sing N N 466 
SER OG  HG   sing N N 467 
SER OXT HXT  sing N N 468 
THR N   CA   sing N N 469 
THR N   H    sing N N 470 
THR N   H2   sing N N 471 
THR CA  C    sing N N 472 
THR CA  CB   sing N N 473 
THR CA  HA   sing N N 474 
THR C   O    doub N N 475 
THR C   OXT  sing N N 476 
THR CB  OG1  sing N N 477 
THR CB  CG2  sing N N 478 
THR CB  HB   sing N N 479 
THR OG1 HG1  sing N N 480 
THR CG2 HG21 sing N N 481 
THR CG2 HG22 sing N N 482 
THR CG2 HG23 sing N N 483 
THR OXT HXT  sing N N 484 
TRP N   CA   sing N N 485 
TRP N   H    sing N N 486 
TRP N   H2   sing N N 487 
TRP CA  C    sing N N 488 
TRP CA  CB   sing N N 489 
TRP CA  HA   sing N N 490 
TRP C   O    doub N N 491 
TRP C   OXT  sing N N 492 
TRP CB  CG   sing N N 493 
TRP CB  HB2  sing N N 494 
TRP CB  HB3  sing N N 495 
TRP CG  CD1  doub Y N 496 
TRP CG  CD2  sing Y N 497 
TRP CD1 NE1  sing Y N 498 
TRP CD1 HD1  sing N N 499 
TRP CD2 CE2  doub Y N 500 
TRP CD2 CE3  sing Y N 501 
TRP NE1 CE2  sing Y N 502 
TRP NE1 HE1  sing N N 503 
TRP CE2 CZ2  sing Y N 504 
TRP CE3 CZ3  doub Y N 505 
TRP CE3 HE3  sing N N 506 
TRP CZ2 CH2  doub Y N 507 
TRP CZ2 HZ2  sing N N 508 
TRP CZ3 CH2  sing Y N 509 
TRP CZ3 HZ3  sing N N 510 
TRP CH2 HH2  sing N N 511 
TRP OXT HXT  sing N N 512 
TYR N   CA   sing N N 513 
TYR N   H    sing N N 514 
TYR N   H2   sing N N 515 
TYR CA  C    sing N N 516 
TYR CA  CB   sing N N 517 
TYR CA  HA   sing N N 518 
TYR C   O    doub N N 519 
TYR C   OXT  sing N N 520 
TYR CB  CG   sing N N 521 
TYR CB  HB2  sing N N 522 
TYR CB  HB3  sing N N 523 
TYR CG  CD1  doub Y N 524 
TYR CG  CD2  sing Y N 525 
TYR CD1 CE1  sing Y N 526 
TYR CD1 HD1  sing N N 527 
TYR CD2 CE2  doub Y N 528 
TYR CD2 HD2  sing N N 529 
TYR CE1 CZ   doub Y N 530 
TYR CE1 HE1  sing N N 531 
TYR CE2 CZ   sing Y N 532 
TYR CE2 HE2  sing N N 533 
TYR CZ  OH   sing N N 534 
TYR OH  HH   sing N N 535 
TYR OXT HXT  sing N N 536 
VAL N   CA   sing N N 537 
VAL N   H    sing N N 538 
VAL N   H2   sing N N 539 
VAL CA  C    sing N N 540 
VAL CA  CB   sing N N 541 
VAL CA  HA   sing N N 542 
VAL C   O    doub N N 543 
VAL C   OXT  sing N N 544 
VAL CB  CG1  sing N N 545 
VAL CB  CG2  sing N N 546 
VAL CB  HB   sing N N 547 
VAL CG1 HG11 sing N N 548 
VAL CG1 HG12 sing N N 549 
VAL CG1 HG13 sing N N 550 
VAL CG2 HG21 sing N N 551 
VAL CG2 HG22 sing N N 552 
VAL CG2 HG23 sing N N 553 
VAL OXT HXT  sing N N 554 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-05-23 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           9BYI 
_em_admin.last_update        2025-05-21 
_em_admin.map_release_date   2025-02-26 
_em_admin.title              'Structure of human K2P13.1 (THIK1) in detergent' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     NONE 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                ? 
_em_entity_assembly_molwt.value                ? 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         50 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? ?         ?   
'IMAGE ACQUISITION'             ? 2  ? ? 1 ?         ?   
MASKING                         ? 3  ? ? ? ?         ?   
'CTF CORRECTION'                ? 4  1 ? ? ?         ?   
'LAYERLINE INDEXING'            ? 5  ? ? ? ?         ?   
'DIFFRACTION INDEXING'          ? 6  ? ? ? ?         ?   
'MODEL FITTING'                 ? 7  ? ? ? ?         ?   
'MODEL REFINEMENT'              ? 8  ? ? ? PHENIX    ?   
OTHER                           ? 9  ? ? ? ?         ?   
'INITIAL EULER ASSIGNMENT'      ? 10 1 ? ? ?         ?   
'FINAL EULER ASSIGNMENT'        ? 11 1 ? ? ?         ?   
CLASSIFICATION                  ? 12 1 ? ? ?         ?   
RECONSTRUCTION                  ? 13 1 ? ? cryoSPARC 3.2 
'VOLUME SELECTION'              ? 14 1 1 1 ?         ?   
'SERIES ALIGNMENT'              ? 15 1 1 1 ?         ?   
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ?         ?   
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ?         ?   
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ?         ?   
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ?         ?   
# 
_em_specimen.concentration           1 
_em_specimen.details                 'mutant protein in detergent' 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'National Institutes of Health/National Institute of Mental Health (NIH/NIMH)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           'R01 MH093603' 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    9BYI 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
H 
K 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . ASN A  1 14  ? 119.171 103.849 146.008 1.00 94.22  ? 14  ASN U N    1 
ATOM   2    C CA   . ASN A  1 14  ? 118.309 103.097 145.106 1.00 98.21  ? 14  ASN U CA   1 
ATOM   3    C C    . ASN A  1 14  ? 117.270 104.018 144.476 1.00 99.29  ? 14  ASN U C    1 
ATOM   4    O O    . ASN A  1 14  ? 116.694 103.699 143.437 1.00 105.47 ? 14  ASN U O    1 
ATOM   5    C CB   . ASN A  1 14  ? 117.623 101.949 145.846 1.00 100.73 ? 14  ASN U CB   1 
ATOM   6    C CG   . ASN A  1 14  ? 116.939 100.972 144.907 1.00 99.75  ? 14  ASN U CG   1 
ATOM   7    O OD1  . ASN A  1 14  ? 117.274 100.889 143.726 1.00 98.97  ? 14  ASN U OD1  1 
ATOM   8    N ND2  . ASN A  1 14  ? 115.979 100.222 145.432 1.00 97.31  ? 14  ASN U ND2  1 
ATOM   9    N N    . GLU A  1 15  ? 117.031 105.161 145.116 1.00 96.48  ? 15  GLU U N    1 
ATOM   10   C CA   . GLU A  1 15  ? 116.085 106.131 144.573 1.00 98.86  ? 15  GLU U CA   1 
ATOM   11   C C    . GLU A  1 15  ? 116.644 106.813 143.329 1.00 102.30 ? 15  GLU U C    1 
ATOM   12   O O    . GLU A  1 15  ? 115.928 106.992 142.335 1.00 105.94 ? 15  GLU U O    1 
ATOM   13   C CB   . GLU A  1 15  ? 115.734 107.164 145.641 1.00 97.57  ? 15  GLU U CB   1 
ATOM   14   C CG   . GLU A  1 15  ? 114.771 108.240 145.182 1.00 101.34 ? 15  GLU U CG   1 
ATOM   15   C CD   . GLU A  1 15  ? 114.485 109.255 146.269 1.00 105.71 ? 15  GLU U CD   1 
ATOM   16   O OE1  . GLU A  1 15  ? 115.161 109.210 147.317 1.00 106.39 ? 15  GLU U OE1  1 
ATOM   17   O OE2  . GLU A  1 15  ? 113.582 110.096 146.078 1.00 106.39 ? 15  GLU U OE2  1 
ATOM   18   N N    . ASP A  1 16  ? 117.924 107.187 143.363 1.00 95.15  ? 16  ASP U N    1 
ATOM   19   C CA   . ASP A  1 16  ? 118.519 107.889 142.233 1.00 96.15  ? 16  ASP U CA   1 
ATOM   20   C C    . ASP A  1 16  ? 118.538 107.019 140.985 1.00 97.77  ? 16  ASP U C    1 
ATOM   21   O O    . ASP A  1 16  ? 118.278 107.503 139.877 1.00 101.72 ? 16  ASP U O    1 
ATOM   22   C CB   . ASP A  1 16  ? 119.928 108.350 142.596 1.00 97.26  ? 16  ASP U CB   1 
ATOM   23   C CG   . ASP A  1 16  ? 119.957 109.192 143.853 1.00 98.96  ? 16  ASP U CG   1 
ATOM   24   O OD1  . ASP A  1 16  ? 118.924 109.816 144.171 1.00 96.94  ? 16  ASP U OD1  1 
ATOM   25   O OD2  . ASP A  1 16  ? 121.010 109.238 144.522 1.00 100.67 ? 16  ASP U OD2  1 
ATOM   26   N N    . ASN A  1 17  ? 118.845 105.732 141.140 1.00 84.82  ? 17  ASN U N    1 
ATOM   27   C CA   . ASN A  1 17  ? 118.843 104.834 139.993 1.00 89.89  ? 17  ASN U CA   1 
ATOM   28   C C    . ASN A  1 17  ? 117.448 104.721 139.392 1.00 93.22  ? 17  ASN U C    1 
ATOM   29   O O    . ASN A  1 17  ? 117.287 104.711 138.165 1.00 96.01  ? 17  ASN U O    1 
ATOM   30   C CB   . ASN A  1 17  ? 119.373 103.463 140.403 1.00 90.17  ? 17  ASN U CB   1 
ATOM   31   C CG   . ASN A  1 17  ? 120.726 103.539 141.077 1.00 92.70  ? 17  ASN U CG   1 
ATOM   32   O OD1  . ASN A  1 17  ? 121.442 104.531 140.949 1.00 92.29  ? 17  ASN U OD1  1 
ATOM   33   N ND2  . ASN A  1 17  ? 121.089 102.489 141.799 1.00 95.63  ? 17  ASN U ND2  1 
ATOM   34   N N    . ALA A  1 18  ? 116.424 104.633 140.241 1.00 77.37  ? 18  ALA U N    1 
ATOM   35   C CA   . ALA A  1 18  ? 115.058 104.570 139.740 1.00 79.33  ? 18  ALA U CA   1 
ATOM   36   C C    . ALA A  1 18  ? 114.695 105.837 138.982 1.00 84.56  ? 18  ALA U C    1 
ATOM   37   O O    . ALA A  1 18  ? 114.070 105.777 137.915 1.00 91.70  ? 18  ALA U O    1 
ATOM   38   C CB   . ALA A  1 18  ? 114.085 104.336 140.894 1.00 76.77  ? 18  ALA U CB   1 
ATOM   39   N N    . ARG A  1 19  ? 115.085 106.998 139.511 1.00 71.33  ? 19  ARG U N    1 
ATOM   40   C CA   . ARG A  1 19  ? 114.811 108.250 138.816 1.00 70.19  ? 19  ARG U CA   1 
ATOM   41   C C    . ARG A  1 19  ? 115.500 108.286 137.456 1.00 76.76  ? 19  ARG U C    1 
ATOM   42   O O    . ARG A  1 19  ? 114.893 108.687 136.451 1.00 82.44  ? 19  ARG U O    1 
ATOM   43   C CB   . ARG A  1 19  ? 115.262 109.424 139.682 1.00 64.76  ? 19  ARG U CB   1 
ATOM   44   C CG   . ARG A  1 19  ? 114.900 110.789 139.146 1.00 69.65  ? 19  ARG U CG   1 
ATOM   45   C CD   . ARG A  1 19  ? 115.509 111.863 140.022 1.00 69.91  ? 19  ARG U CD   1 
ATOM   46   N NE   . ARG A  1 19  ? 115.177 111.655 141.425 1.00 69.08  ? 19  ARG U NE   1 
ATOM   47   C CZ   . ARG A  1 19  ? 115.810 112.229 142.437 1.00 73.34  ? 19  ARG U CZ   1 
ATOM   48   N NH1  . ARG A  1 19  ? 116.831 113.045 142.239 1.00 75.93  ? 19  ARG U NH1  1 
ATOM   49   N NH2  . ARG A  1 19  ? 115.412 111.975 143.680 1.00 72.35  ? 19  ARG U NH2  1 
ATOM   50   N N    . PHE A  1 20  ? 116.758 107.852 137.405 1.00 63.66  ? 20  PHE U N    1 
ATOM   51   C CA   . PHE A  1 20  ? 117.502 107.837 136.147 1.00 61.21  ? 20  PHE U CA   1 
ATOM   52   C C    . PHE A  1 20  ? 116.823 106.935 135.121 1.00 68.92  ? 20  PHE U C    1 
ATOM   53   O O    . PHE A  1 20  ? 116.625 107.323 133.960 1.00 73.73  ? 20  PHE U O    1 
ATOM   54   C CB   . PHE A  1 20  ? 118.932 107.373 136.424 1.00 57.10  ? 20  PHE U CB   1 
ATOM   55   C CG   . PHE A  1 20  ? 119.946 107.894 135.453 1.00 64.03  ? 20  PHE U CG   1 
ATOM   56   C CD1  . PHE A  1 20  ? 119.920 109.212 135.040 1.00 66.54  ? 20  PHE U CD1  1 
ATOM   57   C CD2  . PHE A  1 20  ? 120.950 107.069 134.978 1.00 63.44  ? 20  PHE U CD2  1 
ATOM   58   C CE1  . PHE A  1 20  ? 120.861 109.689 134.153 1.00 67.35  ? 20  PHE U CE1  1 
ATOM   59   C CE2  . PHE A  1 20  ? 121.894 107.542 134.095 1.00 64.18  ? 20  PHE U CE2  1 
ATOM   60   C CZ   . PHE A  1 20  ? 121.850 108.852 133.680 1.00 65.11  ? 20  PHE U CZ   1 
ATOM   61   N N    . LEU A  1 21  ? 116.439 105.728 135.543 1.00 66.04  ? 21  LEU U N    1 
ATOM   62   C CA   . LEU A  1 21  ? 115.797 104.790 134.625 1.00 68.21  ? 21  LEU U CA   1 
ATOM   63   C C    . LEU A  1 21  ? 114.464 105.328 134.123 1.00 74.45  ? 21  LEU U C    1 
ATOM   64   O O    . LEU A  1 21  ? 114.148 105.224 132.926 1.00 81.27  ? 21  LEU U O    1 
ATOM   65   C CB   . LEU A  1 21  ? 115.609 103.442 135.320 1.00 64.40  ? 21  LEU U CB   1 
ATOM   66   C CG   . LEU A  1 21  ? 114.961 102.318 134.514 1.00 72.26  ? 21  LEU U CG   1 
ATOM   67   C CD1  . LEU A  1 21  ? 115.810 101.975 133.300 1.00 74.18  ? 21  LEU U CD1  1 
ATOM   68   C CD2  . LEU A  1 21  ? 114.756 101.092 135.389 1.00 72.61  ? 21  LEU U CD2  1 
ATOM   69   N N    . LEU A  1 22  ? 113.663 105.909 135.019 1.00 60.25  ? 22  LEU U N    1 
ATOM   70   C CA   . LEU A  1 22  ? 112.371 106.448 134.611 1.00 61.79  ? 22  LEU U CA   1 
ATOM   71   C C    . LEU A  1 22  ? 112.543 107.572 133.599 1.00 65.91  ? 22  LEU U C    1 
ATOM   72   O O    . LEU A  1 22  ? 111.821 107.631 132.594 1.00 74.19  ? 22  LEU U O    1 
ATOM   73   C CB   . LEU A  1 22  ? 111.604 106.933 135.840 1.00 53.69  ? 22  LEU U CB   1 
ATOM   74   C CG   . LEU A  1 22  ? 110.131 107.293 135.649 1.00 60.23  ? 22  LEU U CG   1 
ATOM   75   C CD1  . LEU A  1 22  ? 109.362 106.112 135.091 1.00 64.14  ? 22  LEU U CD1  1 
ATOM   76   C CD2  . LEU A  1 22  ? 109.529 107.754 136.962 1.00 61.03  ? 22  LEU U CD2  1 
ATOM   77   N N    . LEU A  1 23  ? 113.501 108.469 133.841 1.00 53.97  ? 23  LEU U N    1 
ATOM   78   C CA   . LEU A  1 23  ? 113.729 109.556 132.897 1.00 57.41  ? 23  LEU U CA   1 
ATOM   79   C C    . LEU A  1 23  ? 114.159 109.024 131.536 1.00 68.00  ? 23  LEU U C    1 
ATOM   80   O O    . LEU A  1 23  ? 113.694 109.505 130.495 1.00 72.92  ? 23  LEU U O    1 
ATOM   81   C CB   . LEU A  1 23  ? 114.768 110.526 133.455 1.00 55.67  ? 23  LEU U CB   1 
ATOM   82   C CG   . LEU A  1 23  ? 115.027 111.781 132.623 1.00 54.08  ? 23  LEU U CG   1 
ATOM   83   C CD1  . LEU A  1 23  ? 113.744 112.560 132.427 1.00 57.35  ? 23  LEU U CD1  1 
ATOM   84   C CD2  . LEU A  1 23  ? 116.083 112.643 133.287 1.00 61.51  ? 23  LEU U CD2  1 
ATOM   85   N N    . ALA A  1 24  ? 115.042 108.021 131.522 1.00 58.20  ? 24  ALA U N    1 
ATOM   86   C CA   . ALA A  1 24  ? 115.481 107.461 130.245 1.00 55.49  ? 24  ALA U CA   1 
ATOM   87   C C    . ALA A  1 24  ? 114.312 106.867 129.466 1.00 60.67  ? 24  ALA U C    1 
ATOM   88   O O    . ALA A  1 24  ? 114.162 107.107 128.258 1.00 69.26  ? 24  ALA U O    1 
ATOM   89   C CB   . ALA A  1 24  ? 116.566 106.412 130.482 1.00 56.40  ? 24  ALA U CB   1 
ATOM   90   N N    . ALA A  1 25  ? 113.461 106.095 130.143 1.00 58.00  ? 25  ALA U N    1 
ATOM   91   C CA   . ALA A  1 25  ? 112.327 105.484 129.457 1.00 62.26  ? 25  ALA U CA   1 
ATOM   92   C C    . ALA A  1 25  ? 111.378 106.542 128.908 1.00 65.83  ? 25  ALA U C    1 
ATOM   93   O O    . ALA A  1 25  ? 110.903 106.438 127.764 1.00 72.07  ? 25  ALA U O    1 
ATOM   94   C CB   . ALA A  1 25  ? 111.589 104.538 130.400 1.00 59.85  ? 25  ALA U CB   1 
ATOM   95   N N    . LEU A  1 26  ? 111.092 107.576 129.704 1.00 56.54  ? 26  LEU U N    1 
ATOM   96   C CA   . LEU A  1 26  ? 110.198 108.626 129.233 1.00 54.24  ? 26  LEU U CA   1 
ATOM   97   C C    . LEU A  1 26  ? 110.776 109.332 128.014 1.00 58.03  ? 26  LEU U C    1 
ATOM   98   O O    . LEU A  1 26  ? 110.046 109.632 127.057 1.00 62.01  ? 26  LEU U O    1 
ATOM   99   C CB   . LEU A  1 26  ? 109.925 109.621 130.360 1.00 60.35  ? 26  LEU U CB   1 
ATOM   100  C CG   . LEU A  1 26  ? 109.167 109.073 131.569 1.00 57.00  ? 26  LEU U CG   1 
ATOM   101  C CD1  . LEU A  1 26  ? 108.841 110.186 132.549 1.00 57.44  ? 26  LEU U CD1  1 
ATOM   102  C CD2  . LEU A  1 26  ? 107.904 108.352 131.137 1.00 58.03  ? 26  LEU U CD2  1 
ATOM   103  N N    . ILE A  1 27  ? 112.084 109.598 128.017 1.00 52.55  ? 27  ILE U N    1 
ATOM   104  C CA   . ILE A  1 27  ? 112.702 110.261 126.873 1.00 55.05  ? 27  ILE U CA   1 
ATOM   105  C C    . ILE A  1 27  ? 112.594 109.400 125.620 1.00 58.86  ? 27  ILE U C    1 
ATOM   106  O O    . ILE A  1 27  ? 112.327 109.905 124.519 1.00 63.60  ? 27  ILE U O    1 
ATOM   107  C CB   . ILE A  1 27  ? 114.165 110.618 127.185 1.00 50.20  ? 27  ILE U CB   1 
ATOM   108  C CG1  . ILE A  1 27  ? 114.229 111.701 128.260 1.00 50.23  ? 27  ILE U CG1  1 
ATOM   109  C CG2  . ILE A  1 27  ? 114.875 111.081 125.930 1.00 56.51  ? 27  ILE U CG2  1 
ATOM   110  C CD1  . ILE A  1 27  ? 115.631 112.094 128.642 1.00 54.39  ? 27  ILE U CD1  1 
ATOM   111  N N    . VAL A  1 28  ? 112.809 108.089 125.759 1.00 58.36  ? 28  VAL U N    1 
ATOM   112  C CA   . VAL A  1 28  ? 112.722 107.210 124.592 1.00 56.57  ? 28  VAL U CA   1 
ATOM   113  C C    . VAL A  1 28  ? 111.312 107.231 124.006 1.00 62.15  ? 28  VAL U C    1 
ATOM   114  O O    . VAL A  1 28  ? 111.124 107.330 122.781 1.00 67.77  ? 28  VAL U O    1 
ATOM   115  C CB   . VAL A  1 28  ? 113.159 105.784 124.963 1.00 52.38  ? 28  VAL U CB   1 
ATOM   116  C CG1  . VAL A  1 28  ? 112.867 104.831 123.821 1.00 56.00  ? 28  VAL U CG1  1 
ATOM   117  C CG2  . VAL A  1 28  ? 114.634 105.762 125.308 1.00 53.76  ? 28  VAL U CG2  1 
ATOM   118  N N    . LEU A  1 29  ? 110.297 107.140 124.869 1.00 53.29  ? 29  LEU U N    1 
ATOM   119  C CA   . LEU A  1 29  ? 108.924 107.192 124.371 1.00 51.44  ? 29  LEU U CA   1 
ATOM   120  C C    . LEU A  1 29  ? 108.640 108.518 123.675 1.00 59.41  ? 29  LEU U C    1 
ATOM   121  O O    . LEU A  1 29  ? 107.979 108.557 122.624 1.00 67.27  ? 29  LEU U O    1 
ATOM   122  C CB   . LEU A  1 29  ? 107.942 106.960 125.515 1.00 52.72  ? 29  LEU U CB   1 
ATOM   123  C CG   . LEU A  1 29  ? 107.992 105.583 126.177 1.00 56.06  ? 29  LEU U CG   1 
ATOM   124  C CD1  . LEU A  1 29  ? 106.939 105.476 127.268 1.00 54.90  ? 29  LEU U CD1  1 
ATOM   125  C CD2  . LEU A  1 29  ? 107.803 104.490 125.143 1.00 58.87  ? 29  LEU U CD2  1 
ATOM   126  N N    . TYR A  1 30  ? 109.137 109.617 124.247 1.00 52.48  ? 30  TYR U N    1 
ATOM   127  C CA   . TYR A  1 30  ? 108.950 110.929 123.640 1.00 54.23  ? 30  TYR U CA   1 
ATOM   128  C C    . TYR A  1 30  ? 109.540 110.970 122.233 1.00 61.04  ? 30  TYR U C    1 
ATOM   129  O O    . TYR A  1 30  ? 108.906 111.475 121.296 1.00 62.88  ? 30  TYR U O    1 
ATOM   130  C CB   . TYR A  1 30  ? 109.595 111.989 124.532 1.00 51.89  ? 30  TYR U CB   1 
ATOM   131  C CG   . TYR A  1 30  ? 109.130 113.405 124.302 1.00 55.21  ? 30  TYR U CG   1 
ATOM   132  C CD1  . TYR A  1 30  ? 107.835 113.789 124.624 1.00 51.99  ? 30  TYR U CD1  1 
ATOM   133  C CD2  . TYR A  1 30  ? 109.991 114.362 123.797 1.00 58.60  ? 30  TYR U CD2  1 
ATOM   134  C CE1  . TYR A  1 30  ? 107.411 115.083 124.424 1.00 51.72  ? 30  TYR U CE1  1 
ATOM   135  C CE2  . TYR A  1 30  ? 109.573 115.660 123.595 1.00 57.62  ? 30  TYR U CE2  1 
ATOM   136  C CZ   . TYR A  1 30  ? 108.282 116.013 123.910 1.00 56.15  ? 30  TYR U CZ   1 
ATOM   137  O OH   . TYR A  1 30  ? 107.859 117.303 123.712 1.00 64.79  ? 30  TYR U OH   1 
ATOM   138  N N    . LEU A  1 31  ? 110.750 110.433 122.068 1.00 54.18  ? 31  LEU U N    1 
ATOM   139  C CA   . LEU A  1 31  ? 111.385 110.438 120.753 1.00 46.50  ? 31  LEU U CA   1 
ATOM   140  C C    . LEU A  1 31  ? 110.574 109.638 119.742 1.00 47.99  ? 31  LEU U C    1 
ATOM   141  O O    . LEU A  1 31  ? 110.371 110.082 118.601 1.00 57.43  ? 31  LEU U O    1 
ATOM   142  C CB   . LEU A  1 31  ? 112.807 109.890 120.844 1.00 44.63  ? 31  LEU U CB   1 
ATOM   143  C CG   . LEU A  1 31  ? 113.832 110.718 121.615 1.00 46.36  ? 31  LEU U CG   1 
ATOM   144  C CD1  . LEU A  1 31  ? 115.213 110.102 121.490 1.00 46.01  ? 31  LEU U CD1  1 
ATOM   145  C CD2  . LEU A  1 31  ? 113.837 112.153 121.125 1.00 53.44  ? 31  LEU U CD2  1 
ATOM   146  N N    . LEU A  1 32  ? 110.102 108.454 120.138 1.00 46.85  ? 32  LEU U N    1 
ATOM   147  C CA   . LEU A  1 32  ? 109.335 107.639 119.198 1.00 45.17  ? 32  LEU U CA   1 
ATOM   148  C C    . LEU A  1 32  ? 108.067 108.360 118.751 1.00 50.24  ? 32  LEU U C    1 
ATOM   149  O O    . LEU A  1 32  ? 107.748 108.403 117.554 1.00 56.50  ? 32  LEU U O    1 
ATOM   150  C CB   . LEU A  1 32  ? 109.002 106.285 119.825 1.00 48.33  ? 32  LEU U CB   1 
ATOM   151  C CG   . LEU A  1 32  ? 110.189 105.339 120.009 1.00 46.43  ? 32  LEU U CG   1 
ATOM   152  C CD1  . LEU A  1 32  ? 109.733 104.011 120.580 1.00 49.87  ? 32  LEU U CD1  1 
ATOM   153  C CD2  . LEU A  1 32  ? 110.906 105.132 118.692 1.00 47.27  ? 32  LEU U CD2  1 
ATOM   154  N N    . GLY A  1 33  ? 107.339 108.951 119.702 1.00 55.68  ? 33  GLY U N    1 
ATOM   155  C CA   . GLY A  1 33  ? 106.129 109.674 119.334 1.00 54.10  ? 33  GLY U CA   1 
ATOM   156  C C    . GLY A  1 33  ? 106.402 110.845 118.407 1.00 59.14  ? 33  GLY U C    1 
ATOM   157  O O    . GLY A  1 33  ? 105.679 111.059 117.421 1.00 62.89  ? 33  GLY U O    1 
ATOM   158  N N    . GLY A  1 34  ? 107.450 111.618 118.701 1.00 60.89  ? 34  GLY U N    1 
ATOM   159  C CA   . GLY A  1 34  ? 107.769 112.749 117.851 1.00 55.57  ? 34  GLY U CA   1 
ATOM   160  C C    . GLY A  1 34  ? 108.101 112.340 116.429 1.00 53.12  ? 34  GLY U C    1 
ATOM   161  O O    . GLY A  1 34  ? 107.648 112.971 115.469 1.00 56.64  ? 34  GLY U O    1 
ATOM   162  N N    . ALA A  1 35  ? 108.892 111.278 116.274 1.00 45.64  ? 35  ALA U N    1 
ATOM   163  C CA   . ALA A  1 35  ? 109.201 110.803 114.928 1.00 48.90  ? 35  ALA U CA   1 
ATOM   164  C C    . ALA A  1 35  ? 107.937 110.380 114.193 1.00 45.62  ? 35  ALA U C    1 
ATOM   165  O O    . ALA A  1 35  ? 107.748 110.709 113.009 1.00 54.40  ? 35  ALA U O    1 
ATOM   166  C CB   . ALA A  1 35  ? 110.193 109.646 114.996 1.00 51.49  ? 35  ALA U CB   1 
ATOM   167  N N    . ALA A  1 36  ? 107.048 109.664 114.891 1.00 53.45  ? 36  ALA U N    1 
ATOM   168  C CA   . ALA A  1 36  ? 105.818 109.214 114.253 1.00 52.56  ? 36  ALA U CA   1 
ATOM   169  C C    . ALA A  1 36  ? 104.998 110.389 113.741 1.00 56.21  ? 36  ALA U C    1 
ATOM   170  O O    . ALA A  1 36  ? 104.422 110.325 112.648 1.00 61.35  ? 36  ALA U O    1 
ATOM   171  C CB   . ALA A  1 36  ? 104.994 108.371 115.226 1.00 56.84  ? 36  ALA U CB   1 
ATOM   172  N N    . VAL A  1 37  ? 104.928 111.472 114.515 1.00 55.56  ? 37  VAL U N    1 
ATOM   173  C CA   . VAL A  1 37  ? 104.138 112.625 114.074 1.00 51.10  ? 37  VAL U CA   1 
ATOM   174  C C    . VAL A  1 37  ? 104.813 113.327 112.894 1.00 60.67  ? 37  VAL U C    1 
ATOM   175  O O    . VAL A  1 37  ? 104.162 113.674 111.895 1.00 67.97  ? 37  VAL U O    1 
ATOM   176  C CB   . VAL A  1 37  ? 103.901 113.592 115.246 1.00 52.91  ? 37  VAL U CB   1 
ATOM   177  C CG1  . VAL A  1 37  ? 103.160 114.823 114.768 1.00 53.58  ? 37  VAL U CG1  1 
ATOM   178  C CG2  . VAL A  1 37  ? 103.123 112.902 116.348 1.00 58.75  ? 37  VAL U CG2  1 
ATOM   179  N N    . PHE A  1 38  ? 106.127 113.550 112.988 1.00 58.79  ? 38  PHE U N    1 
ATOM   180  C CA   . PHE A  1 38  ? 106.807 114.352 111.977 1.00 50.06  ? 38  PHE U CA   1 
ATOM   181  C C    . PHE A  1 38  ? 106.777 113.687 110.606 1.00 57.56  ? 38  PHE U C    1 
ATOM   182  O O    . PHE A  1 38  ? 106.615 114.368 109.579 1.00 56.22  ? 38  PHE U O    1 
ATOM   183  C CB   . PHE A  1 38  ? 108.246 114.631 112.404 1.00 49.51  ? 38  PHE U CB   1 
ATOM   184  C CG   . PHE A  1 38  ? 108.409 115.887 113.207 1.00 49.81  ? 38  PHE U CG   1 
ATOM   185  C CD1  . PHE A  1 38  ? 108.274 117.124 112.609 1.00 50.97  ? 38  PHE U CD1  1 
ATOM   186  C CD2  . PHE A  1 38  ? 108.711 115.830 114.553 1.00 50.78  ? 38  PHE U CD2  1 
ATOM   187  C CE1  . PHE A  1 38  ? 108.428 118.280 113.342 1.00 55.10  ? 38  PHE U CE1  1 
ATOM   188  C CE2  . PHE A  1 38  ? 108.868 116.982 115.291 1.00 47.96  ? 38  PHE U CE2  1 
ATOM   189  C CZ   . PHE A  1 38  ? 108.728 118.208 114.684 1.00 51.42  ? 38  PHE U CZ   1 
ATOM   190  N N    . SER A  1 39  ? 106.961 112.364 110.556 1.00 58.58  ? 39  SER U N    1 
ATOM   191  C CA   . SER A  1 39  ? 106.940 111.690 109.260 1.00 51.51  ? 39  SER U CA   1 
ATOM   192  C C    . SER A  1 39  ? 105.616 111.930 108.540 1.00 56.62  ? 39  SER U C    1 
ATOM   193  O O    . SER A  1 39  ? 105.584 112.310 107.357 1.00 68.79  ? 39  SER U O    1 
ATOM   194  C CB   . SER A  1 39  ? 107.184 110.193 109.442 1.00 55.90  ? 39  SER U CB   1 
ATOM   195  O OG   . SER A  1 39  ? 106.840 109.482 108.269 1.00 67.29  ? 39  SER U OG   1 
ATOM   196  N N    . ALA A  1 40  ? 104.508 111.723 109.251 1.00 53.41  ? 40  ALA U N    1 
ATOM   197  C CA   . ALA A  1 40  ? 103.190 111.926 108.664 1.00 58.27  ? 40  ALA U CA   1 
ATOM   198  C C    . ALA A  1 40  ? 102.965 113.382 108.294 1.00 60.27  ? 40  ALA U C    1 
ATOM   199  O O    . ALA A  1 40  ? 102.183 113.673 107.383 1.00 64.97  ? 40  ALA U O    1 
ATOM   200  C CB   . ALA A  1 40  ? 102.105 111.455 109.633 1.00 56.78  ? 40  ALA U CB   1 
ATOM   201  N N    . LEU A  1 41  ? 103.626 114.308 108.986 1.00 64.78  ? 41  LEU U N    1 
ATOM   202  C CA   . LEU A  1 41  ? 103.450 115.708 108.615 1.00 59.48  ? 41  LEU U CA   1 
ATOM   203  C C    . LEU A  1 41  ? 104.213 116.093 107.345 1.00 59.82  ? 41  LEU U C    1 
ATOM   204  O O    . LEU A  1 41  ? 103.747 116.966 106.604 1.00 60.65  ? 41  LEU U O    1 
ATOM   205  C CB   . LEU A  1 41  ? 103.865 116.620 109.769 1.00 60.86  ? 41  LEU U CB   1 
ATOM   206  C CG   . LEU A  1 41  ? 102.808 116.825 110.856 1.00 57.91  ? 41  LEU U CG   1 
ATOM   207  C CD1  . LEU A  1 41  ? 103.315 117.772 111.928 1.00 59.73  ? 41  LEU U CD1  1 
ATOM   208  C CD2  . LEU A  1 41  ? 101.517 117.344 110.254 1.00 55.65  ? 41  LEU U CD2  1 
ATOM   209  N N    . GLU A  1 42  ? 105.371 115.478 107.070 1.00 68.28  ? 42  GLU U N    1 
ATOM   210  C CA   . GLU A  1 42  ? 106.263 116.023 106.044 1.00 61.04  ? 42  GLU U CA   1 
ATOM   211  C C    . GLU A  1 42  ? 106.454 115.175 104.783 1.00 65.14  ? 42  GLU U C    1 
ATOM   212  O O    . GLU A  1 42  ? 106.952 115.706 103.769 1.00 70.85  ? 42  GLU U O    1 
ATOM   213  C CB   . GLU A  1 42  ? 107.644 116.296 106.653 1.00 64.76  ? 42  GLU U CB   1 
ATOM   214  C CG   . GLU A  1 42  ? 107.605 117.213 107.863 1.00 68.31  ? 42  GLU U CG   1 
ATOM   215  C CD   . GLU A  1 42  ? 107.479 118.672 107.481 1.00 74.34  ? 42  GLU U CD   1 
ATOM   216  O OE1  . GLU A  1 42  ? 107.450 118.970 106.270 1.00 80.89  ? 42  GLU U OE1  1 
ATOM   217  O OE2  . GLU A  1 42  ? 107.410 119.524 108.391 1.00 77.00  ? 42  GLU U OE2  1 
ATOM   218  N N    . LEU A  1 43  ? 106.085 113.891 104.802 1.00 69.41  ? 43  LEU U N    1 
ATOM   219  C CA   . LEU A  1 43  ? 106.485 113.003 103.709 1.00 71.35  ? 43  LEU U CA   1 
ATOM   220  C C    . LEU A  1 43  ? 105.923 113.448 102.356 1.00 75.53  ? 43  LEU U C    1 
ATOM   221  O O    . LEU A  1 43  ? 106.639 113.440 101.343 1.00 76.25  ? 43  LEU U O    1 
ATOM   222  C CB   . LEU A  1 43  ? 106.054 111.574 104.023 1.00 66.04  ? 43  LEU U CB   1 
ATOM   223  C CG   . LEU A  1 43  ? 106.513 110.494 103.043 1.00 67.47  ? 43  LEU U CG   1 
ATOM   224  C CD1  . LEU A  1 43  ? 108.018 110.540 102.869 1.00 65.34  ? 43  LEU U CD1  1 
ATOM   225  C CD2  . LEU A  1 43  ? 106.073 109.128 103.525 1.00 70.59  ? 43  LEU U CD2  1 
ATOM   226  N N    . ALA A  1 44  ? 104.641 113.821 102.310 1.00 71.96  ? 44  ALA U N    1 
ATOM   227  C CA   . ALA A  1 44  ? 104.010 114.138 101.031 1.00 70.27  ? 44  ALA U CA   1 
ATOM   228  C C    . ALA A  1 44  ? 104.635 115.367 100.384 1.00 79.30  ? 44  ALA U C    1 
ATOM   229  O O    . ALA A  1 44  ? 104.875 115.390 99.168  1.00 88.01  ? 44  ALA U O    1 
ATOM   230  C CB   . ALA A  1 44  ? 102.507 114.345 101.229 1.00 71.11  ? 44  ALA U CB   1 
ATOM   231  N N    . HIS A  1 45  ? 104.900 116.403 101.181 1.00 78.99  ? 45  HIS U N    1 
ATOM   232  C CA   . HIS A  1 45  ? 105.557 117.590 100.650 1.00 77.07  ? 45  HIS U CA   1 
ATOM   233  C C    . HIS A  1 45  ? 106.938 117.249 100.111 1.00 80.95  ? 45  HIS U C    1 
ATOM   234  O O    . HIS A  1 45  ? 107.335 117.733 99.040  1.00 80.45  ? 45  HIS U O    1 
ATOM   235  C CB   . HIS A  1 45  ? 105.648 118.666 101.734 1.00 76.30  ? 45  HIS U CB   1 
ATOM   236  C CG   . HIS A  1 45  ? 106.126 119.991 101.234 1.00 82.08  ? 45  HIS U CG   1 
ATOM   237  N ND1  . HIS A  1 45  ? 105.297 120.896 100.610 1.00 83.83  ? 45  HIS U ND1  1 
ATOM   238  C CD2  . HIS A  1 45  ? 107.350 120.569 101.269 1.00 84.28  ? 45  HIS U CD2  1 
ATOM   239  C CE1  . HIS A  1 45  ? 105.986 121.975 100.282 1.00 84.73  ? 45  HIS U CE1  1 
ATOM   240  N NE2  . HIS A  1 45  ? 107.237 121.801 100.670 1.00 83.29  ? 45  HIS U NE2  1 
ATOM   241  N N    . GLU A  1 46  ? 107.684 116.398 100.827 1.00 83.73  ? 46  GLU U N    1 
ATOM   242  C CA   . GLU A  1 46  ? 108.998 116.014 100.320 1.00 78.31  ? 46  GLU U CA   1 
ATOM   243  C C    . GLU A  1 46  ? 108.886 115.341 98.954  1.00 80.29  ? 46  GLU U C    1 
ATOM   244  O O    . GLU A  1 46  ? 109.636 115.662 98.019  1.00 88.30  ? 46  GLU U O    1 
ATOM   245  C CB   . GLU A  1 46  ? 109.703 115.093 101.315 1.00 82.21  ? 46  GLU U CB   1 
ATOM   246  C CG   . GLU A  1 46  ? 111.120 114.730 100.911 1.00 84.28  ? 46  GLU U CG   1 
ATOM   247  C CD   . GLU A  1 46  ? 111.537 113.359 101.393 1.00 91.50  ? 46  GLU U CD   1 
ATOM   248  O OE1  . GLU A  1 46  ? 110.647 112.537 101.695 1.00 97.69  ? 46  GLU U OE1  1 
ATOM   249  O OE2  . GLU A  1 46  ? 112.754 113.096 101.471 1.00 91.39  ? 46  GLU U OE2  1 
ATOM   250  N N    . ARG A  1 47  ? 107.942 114.407 98.818  1.00 79.36  ? 47  ARG U N    1 
ATOM   251  C CA   . ARG A  1 47  ? 107.801 113.693 97.551  1.00 80.14  ? 47  ARG U CA   1 
ATOM   252  C C    . ARG A  1 47  ? 107.419 114.637 96.412  1.00 84.21  ? 47  ARG U C    1 
ATOM   253  O O    . ARG A  1 47  ? 107.952 114.531 95.293  1.00 88.13  ? 47  ARG U O    1 
ATOM   254  C CB   . ARG A  1 47  ? 106.768 112.577 97.688  1.00 81.74  ? 47  ARG U CB   1 
ATOM   255  C CG   . ARG A  1 47  ? 107.270 111.368 98.453  1.00 85.91  ? 47  ARG U CG   1 
ATOM   256  C CD   . ARG A  1 47  ? 106.166 110.342 98.644  1.00 86.14  ? 47  ARG U CD   1 
ATOM   257  N NE   . ARG A  1 47  ? 106.641 109.162 99.358  1.00 88.84  ? 47  ARG U NE   1 
ATOM   258  C CZ   . ARG A  1 47  ? 105.855 108.203 99.817  1.00 90.64  ? 47  ARG U CZ   1 
ATOM   259  N NH1  . ARG A  1 47  ? 104.541 108.248 99.665  1.00 90.92  ? 47  ARG U NH1  1 
ATOM   260  N NH2  . ARG A  1 47  ? 106.399 107.164 100.450 1.00 89.65  ? 47  ARG U NH2  1 
ATOM   261  N N    . GLN A  1 48  ? 106.499 115.568 96.676  1.00 81.66  ? 48  GLN U N    1 
ATOM   262  C CA   . GLN A  1 48  ? 106.101 116.507 95.631  1.00 76.51  ? 48  GLN U CA   1 
ATOM   263  C C    . GLN A  1 48  ? 107.277 117.372 95.190  1.00 81.67  ? 48  GLN U C    1 
ATOM   264  O O    . GLN A  1 48  ? 107.462 117.614 93.987  1.00 86.29  ? 48  GLN U O    1 
ATOM   265  C CB   . GLN A  1 48  ? 104.945 117.376 96.112  1.00 78.85  ? 48  GLN U CB   1 
ATOM   266  C CG   . GLN A  1 48  ? 103.635 116.630 96.255  1.00 81.52  ? 48  GLN U CG   1 
ATOM   267  C CD   . GLN A  1 48  ? 102.470 117.552 96.537  1.00 89.12  ? 48  GLN U CD   1 
ATOM   268  O OE1  . GLN A  1 48  ? 102.649 118.743 96.783  1.00 90.77  ? 48  GLN U OE1  1 
ATOM   269  N NE2  . GLN A  1 48  ? 101.260 117.003 96.502  1.00 90.20  ? 48  GLN U NE2  1 
ATOM   270  N N    . ALA A  1 49  ? 108.088 117.837 96.142  1.00 81.59  ? 49  ALA U N    1 
ATOM   271  C CA   . ALA A  1 49  ? 109.248 118.645 95.771  1.00 77.45  ? 49  ALA U CA   1 
ATOM   272  C C    . ALA A  1 49  ? 110.223 117.850 94.910  1.00 75.89  ? 49  ALA U C    1 
ATOM   273  O O    . ALA A  1 49  ? 110.768 118.368 93.924  1.00 72.80  ? 49  ALA U O    1 
ATOM   274  C CB   . ALA A  1 49  ? 109.944 119.172 97.024  1.00 79.42  ? 49  ALA U CB   1 
ATOM   275  N N    . LYS A  1 50  ? 110.459 116.586 95.268  1.00 80.33  ? 50  LYS U N    1 
ATOM   276  C CA   . LYS A  1 50  ? 111.366 115.760 94.477  1.00 77.30  ? 50  LYS U CA   1 
ATOM   277  C C    . LYS A  1 50  ? 110.874 115.606 93.040  1.00 79.25  ? 50  LYS U C    1 
ATOM   278  O O    . LYS A  1 50  ? 111.646 115.762 92.085  1.00 80.80  ? 50  LYS U O    1 
ATOM   279  C CB   . LYS A  1 50  ? 111.543 114.391 95.131  1.00 76.22  ? 50  LYS U CB   1 
ATOM   280  C CG   . LYS A  1 50  ? 112.358 114.403 96.408  1.00 75.16  ? 50  LYS U CG   1 
ATOM   281  C CD   . LYS A  1 50  ? 112.572 112.987 96.923  1.00 79.07  ? 50  LYS U CD   1 
ATOM   282  C CE   . LYS A  1 50  ? 113.269 112.983 98.273  1.00 76.15  ? 50  LYS U CE   1 
ATOM   283  N NZ   . LYS A  1 50  ? 114.629 113.575 98.203  1.00 77.01  ? 50  LYS U NZ   1 
ATOM   284  N N    . GLN A  1 51  ? 109.589 115.296 92.866  1.00 85.27  ? 51  GLN U N    1 
ATOM   285  C CA   . GLN A  1 51  ? 109.062 115.154 91.508  1.00 84.16  ? 51  GLN U CA   1 
ATOM   286  C C    . GLN A  1 51  ? 109.116 116.466 90.730  1.00 86.97  ? 51  GLN U C    1 
ATOM   287  O O    . GLN A  1 51  ? 109.386 116.471 89.519  1.00 88.26  ? 51  GLN U O    1 
ATOM   288  C CB   . GLN A  1 51  ? 107.630 114.622 91.553  1.00 83.31  ? 51  GLN U CB   1 
ATOM   289  C CG   . GLN A  1 51  ? 106.872 114.800 90.253  1.00 86.55  ? 51  GLN U CG   1 
ATOM   290  C CD   . GLN A  1 51  ? 105.690 113.860 90.139  1.00 92.97  ? 51  GLN U CD   1 
ATOM   291  O OE1  . GLN A  1 51  ? 105.530 113.165 89.137  1.00 91.55  ? 51  GLN U OE1  1 
ATOM   292  N NE2  . GLN A  1 51  ? 104.852 113.839 91.165  1.00 94.15  ? 51  GLN U NE2  1 
ATOM   293  N N    . ARG A  1 52  ? 108.896 117.595 91.408  1.00 89.37  ? 52  ARG U N    1 
ATOM   294  C CA   . ARG A  1 52  ? 109.013 118.881 90.726  1.00 84.57  ? 52  ARG U CA   1 
ATOM   295  C C    . ARG A  1 52  ? 110.431 119.102 90.208  1.00 88.76  ? 52  ARG U C    1 
ATOM   296  O O    . ARG A  1 52  ? 110.627 119.521 89.057  1.00 92.47  ? 52  ARG U O    1 
ATOM   297  C CB   . ARG A  1 52  ? 108.607 120.013 91.669  1.00 85.68  ? 52  ARG U CB   1 
ATOM   298  C CG   . ARG A  1 52  ? 108.296 121.323 90.968  1.00 83.70  ? 52  ARG U CG   1 
ATOM   299  C CD   . ARG A  1 52  ? 108.375 122.496 91.932  1.00 88.59  ? 52  ARG U CD   1 
ATOM   300  N NE   . ARG A  1 52  ? 107.703 122.221 93.196  1.00 91.48  ? 52  ARG U NE   1 
ATOM   301  C CZ   . ARG A  1 52  ? 106.425 122.478 93.438  1.00 91.34  ? 52  ARG U CZ   1 
ATOM   302  N NH1  . ARG A  1 52  ? 105.642 123.010 92.518  1.00 93.36  ? 52  ARG U NH1  1 
ATOM   303  N NH2  . ARG A  1 52  ? 105.924 122.191 94.635  1.00 87.57  ? 52  ARG U NH2  1 
ATOM   304  N N    . TRP A  1 53  ? 111.434 118.811 91.040  1.00 84.82  ? 53  TRP U N    1 
ATOM   305  C CA   . TRP A  1 53  ? 112.811 118.976 90.591  1.00 80.40  ? 53  TRP U CA   1 
ATOM   306  C C    . TRP A  1 53  ? 113.126 118.056 89.422  1.00 79.78  ? 53  TRP U C    1 
ATOM   307  O O    . TRP A  1 53  ? 113.816 118.455 88.476  1.00 78.49  ? 53  TRP U O    1 
ATOM   308  C CB   . TRP A  1 53  ? 113.793 118.723 91.732  1.00 81.19  ? 53  TRP U CB   1 
ATOM   309  C CG   . TRP A  1 53  ? 115.157 118.344 91.231  1.00 80.50  ? 53  TRP U CG   1 
ATOM   310  C CD1  . TRP A  1 53  ? 115.772 117.137 91.367  1.00 80.42  ? 53  TRP U CD1  1 
ATOM   311  C CD2  . TRP A  1 53  ? 116.058 119.170 90.486  1.00 79.11  ? 53  TRP U CD2  1 
ATOM   312  N NE1  . TRP A  1 53  ? 117.007 117.164 90.768  1.00 77.93  ? 53  TRP U NE1  1 
ATOM   313  C CE2  . TRP A  1 53  ? 117.206 118.401 90.219  1.00 75.02  ? 53  TRP U CE2  1 
ATOM   314  C CE3  . TRP A  1 53  ? 116.010 120.489 90.027  1.00 81.35  ? 53  TRP U CE3  1 
ATOM   315  C CZ2  . TRP A  1 53  ? 118.292 118.905 89.511  1.00 72.58  ? 53  TRP U CZ2  1 
ATOM   316  C CZ3  . TRP A  1 53  ? 117.091 120.987 89.324  1.00 76.16  ? 53  TRP U CZ3  1 
ATOM   317  C CH2  . TRP A  1 53  ? 118.216 120.197 89.076  1.00 71.41  ? 53  TRP U CH2  1 
ATOM   318  N N    . GLU A  1 54  ? 112.649 116.812 89.478  1.00 91.93  ? 54  GLU U N    1 
ATOM   319  C CA   . GLU A  1 54  ? 112.911 115.892 88.375  1.00 90.74  ? 54  GLU U CA   1 
ATOM   320  C C    . GLU A  1 54  ? 112.331 116.419 87.066  1.00 89.65  ? 54  GLU U C    1 
ATOM   321  O O    . GLU A  1 54  ? 113.000 116.388 86.021  1.00 89.59  ? 54  GLU U O    1 
ATOM   322  C CB   . GLU A  1 54  ? 112.338 114.510 88.692  1.00 92.57  ? 54  GLU U CB   1 
ATOM   323  C CG   . GLU A  1 54  ? 112.463 113.511 87.558  1.00 95.52  ? 54  GLU U CG   1 
ATOM   324  C CD   . GLU A  1 54  ? 113.827 112.857 87.503  1.00 100.20 ? 54  GLU U CD   1 
ATOM   325  O OE1  . GLU A  1 54  ? 114.449 112.684 88.575  1.00 101.15 ? 54  GLU U OE1  1 
ATOM   326  O OE2  . GLU A  1 54  ? 114.279 112.516 86.390  1.00 97.33  ? 54  GLU U OE2  1 
ATOM   327  N N    . GLU A  1 55  ? 111.098 116.924 87.101  1.00 97.67  ? 55  GLU U N    1 
ATOM   328  C CA   . GLU A  1 55  ? 110.495 117.442 85.879  1.00 96.26  ? 55  GLU U CA   1 
ATOM   329  C C    . GLU A  1 55  ? 111.256 118.656 85.350  1.00 97.90  ? 55  GLU U C    1 
ATOM   330  O O    . GLU A  1 55  ? 111.485 118.779 84.137  1.00 97.40  ? 55  GLU U O    1 
ATOM   331  C CB   . GLU A  1 55  ? 109.029 117.795 86.119  1.00 98.23  ? 55  GLU U CB   1 
ATOM   332  C CG   . GLU A  1 55  ? 108.285 118.201 84.862  1.00 99.48  ? 55  GLU U CG   1 
ATOM   333  C CD   . GLU A  1 55  ? 108.171 117.062 83.867  1.00 105.55 ? 55  GLU U CD   1 
ATOM   334  O OE1  . GLU A  1 55  ? 108.200 115.892 84.299  1.00 107.21 ? 55  GLU U OE1  1 
ATOM   335  O OE2  . GLU A  1 55  ? 108.053 117.337 82.654  1.00 107.10 ? 55  GLU U OE2  1 
ATOM   336  N N    . ARG A  1 56  ? 111.671 119.557 86.244  1.00 97.53  ? 56  ARG U N    1 
ATOM   337  C CA   . ARG A  1 56  ? 112.420 120.730 85.796  1.00 91.85  ? 56  ARG U CA   1 
ATOM   338  C C    . ARG A  1 56  ? 113.748 120.331 85.164  1.00 91.71  ? 56  ARG U C    1 
ATOM   339  O O    . ARG A  1 56  ? 114.142 120.879 84.125  1.00 91.41  ? 56  ARG U O    1 
ATOM   340  C CB   . ARG A  1 56  ? 112.651 121.685 86.965  1.00 89.70  ? 56  ARG U CB   1 
ATOM   341  C CG   . ARG A  1 56  ? 111.445 122.534 87.319  1.00 91.86  ? 56  ARG U CG   1 
ATOM   342  C CD   . ARG A  1 56  ? 111.730 123.409 88.526  1.00 91.41  ? 56  ARG U CD   1 
ATOM   343  N NE   . ARG A  1 56  ? 110.599 124.262 88.859  1.00 92.20  ? 56  ARG U NE   1 
ATOM   344  C CZ   . ARG A  1 56  ? 110.529 125.012 89.947  1.00 94.97  ? 56  ARG U CZ   1 
ATOM   345  N NH1  . ARG A  1 56  ? 111.501 125.032 90.840  1.00 96.93  ? 56  ARG U NH1  1 
ATOM   346  N NH2  . ARG A  1 56  ? 109.448 125.764 90.146  1.00 96.82  ? 56  ARG U NH2  1 
ATOM   347  N N    . LEU A  1 57  ? 114.453 119.380 85.779  1.00 91.52  ? 57  LEU U N    1 
ATOM   348  C CA   . LEU A  1 57  ? 115.722 118.927 85.217  1.00 88.26  ? 57  LEU U CA   1 
ATOM   349  C C    . LEU A  1 57  ? 115.529 118.303 83.844  1.00 91.16  ? 57  LEU U C    1 
ATOM   350  O O    . LEU A  1 57  ? 116.318 118.553 82.927  1.00 89.64  ? 57  LEU U O    1 
ATOM   351  C CB   . LEU A  1 57  ? 116.394 117.934 86.163  1.00 86.70  ? 57  LEU U CB   1 
ATOM   352  C CG   . LEU A  1 57  ? 117.657 117.267 85.615  1.00 84.00  ? 57  LEU U CG   1 
ATOM   353  C CD1  . LEU A  1 57  ? 118.715 118.300 85.293  1.00 85.09  ? 57  LEU U CD1  1 
ATOM   354  C CD2  . LEU A  1 57  ? 118.191 116.239 86.595  1.00 88.12  ? 57  LEU U CD2  1 
ATOM   355  N N    . ALA A  1 58  ? 114.494 117.475 83.685  1.00 102.32 ? 58  ALA U N    1 
ATOM   356  C CA   . ALA A  1 58  ? 114.250 116.881 82.374  1.00 98.06  ? 58  ALA U CA   1 
ATOM   357  C C    . ALA A  1 58  ? 113.957 117.948 81.328  1.00 97.84  ? 58  ALA U C    1 
ATOM   358  O O    . ALA A  1 58  ? 114.486 117.896 80.210  1.00 95.43  ? 58  ALA U O    1 
ATOM   359  C CB   . ALA A  1 58  ? 113.101 115.880 82.455  1.00 100.97 ? 58  ALA U CB   1 
ATOM   360  N N    . GLN A  1 59  ? 113.166 118.960 81.688  1.00 107.30 ? 59  GLN U N    1 
ATOM   361  C CA   . GLN A  1 59  ? 112.860 120.013 80.724  1.00 106.75 ? 59  GLN U CA   1 
ATOM   362  C C    . GLN A  1 59  ? 114.119 120.768 80.318  1.00 105.78 ? 59  GLN U C    1 
ATOM   363  O O    . GLN A  1 59  ? 114.335 121.040 79.127  1.00 103.90 ? 59  GLN U O    1 
ATOM   364  C CB   . GLN A  1 59  ? 111.821 120.972 81.301  1.00 107.72 ? 59  GLN U CB   1 
ATOM   365  C CG   . GLN A  1 59  ? 111.510 122.153 80.402  1.00 108.00 ? 59  GLN U CG   1 
ATOM   366  C CD   . GLN A  1 59  ? 110.759 121.750 79.152  1.00 112.43 ? 59  GLN U CD   1 
ATOM   367  O OE1  . GLN A  1 59  ? 110.250 120.632 79.050  1.00 112.31 ? 59  GLN U OE1  1 
ATOM   368  N NE2  . GLN A  1 59  ? 110.681 122.660 78.188  1.00 111.31 ? 59  GLN U NE2  1 
ATOM   369  N N    . PHE A  1 60  ? 114.979 121.092 81.288  1.00 103.72 ? 60  PHE U N    1 
ATOM   370  C CA   . PHE A  1 60  ? 116.189 121.829 80.943  1.00 101.39 ? 60  PHE U CA   1 
ATOM   371  C C    . PHE A  1 60  ? 117.114 120.978 80.085  1.00 99.70  ? 60  PHE U C    1 
ATOM   372  O O    . PHE A  1 60  ? 117.686 121.468 79.102  1.00 97.54  ? 60  PHE U O    1 
ATOM   373  C CB   . PHE A  1 60  ? 116.910 122.305 82.201  1.00 100.57 ? 60  PHE U CB   1 
ATOM   374  C CG   . PHE A  1 60  ? 118.142 123.127 81.916  1.00 98.61  ? 60  PHE U CG   1 
ATOM   375  C CD1  . PHE A  1 60  ? 118.043 124.489 81.706  1.00 98.23  ? 60  PHE U CD1  1 
ATOM   376  C CD2  . PHE A  1 60  ? 119.387 122.533 81.863  1.00 98.41  ? 60  PHE U CD2  1 
ATOM   377  C CE1  . PHE A  1 60  ? 119.171 125.243 81.450  1.00 95.18  ? 60  PHE U CE1  1 
ATOM   378  C CE2  . PHE A  1 60  ? 120.517 123.284 81.604  1.00 94.30  ? 60  PHE U CE2  1 
ATOM   379  C CZ   . PHE A  1 60  ? 120.406 124.641 81.396  1.00 93.11  ? 60  PHE U CZ   1 
ATOM   380  N N    . SER A  1 61  ? 117.273 119.698 80.432  1.00 111.42 ? 61  SER U N    1 
ATOM   381  C CA   . SER A  1 61  ? 118.175 118.858 79.661  1.00 110.56 ? 61  SER U CA   1 
ATOM   382  C C    . SER A  1 61  ? 117.614 118.551 78.286  1.00 109.58 ? 61  SER U C    1 
ATOM   383  O O    . SER A  1 61  ? 118.354 118.083 77.416  1.00 107.51 ? 61  SER U O    1 
ATOM   384  C CB   . SER A  1 61  ? 118.458 117.552 80.405  1.00 111.50 ? 61  SER U CB   1 
ATOM   385  O OG   . SER A  1 61  ? 119.228 116.672 79.607  1.00 113.23 ? 61  SER U OG   1 
ATOM   386  N N    . ARG A  1 62  ? 116.325 118.811 78.074  1.00 118.18 ? 62  ARG U N    1 
ATOM   387  C CA   . ARG A  1 62  ? 115.680 118.519 76.803  1.00 118.68 ? 62  ARG U CA   1 
ATOM   388  C C    . ARG A  1 62  ? 115.729 119.718 75.867  1.00 117.64 ? 62  ARG U C    1 
ATOM   389  O O    . ARG A  1 62  ? 115.906 119.554 74.655  1.00 118.04 ? 62  ARG U O    1 
ATOM   390  C CB   . ARG A  1 62  ? 114.229 118.095 77.031  1.00 119.84 ? 62  ARG U CB   1 
ATOM   391  C CG   . ARG A  1 62  ? 113.511 117.614 75.783  1.00 119.04 ? 62  ARG U CG   1 
ATOM   392  C CD   . ARG A  1 62  ? 112.072 117.251 76.102  1.00 120.26 ? 62  ARG U CD   1 
ATOM   393  N NE   . ARG A  1 62  ? 111.979 116.364 77.257  1.00 120.88 ? 62  ARG U NE   1 
ATOM   394  C CZ   . ARG A  1 62  ? 110.853 116.075 77.890  1.00 121.29 ? 62  ARG U CZ   1 
ATOM   395  N NH1  . ARG A  1 62  ? 109.694 116.590 77.512  1.00 122.62 ? 62  ARG U NH1  1 
ATOM   396  N NH2  . ARG A  1 62  ? 110.890 115.247 78.932  1.00 120.30 ? 62  ARG U NH2  1 
ATOM   397  N N    . GLY A  1 63  ? 115.576 120.928 76.411  1.00 115.68 ? 63  GLY U N    1 
ATOM   398  C CA   . GLY A  1 63  ? 115.528 122.104 75.555  1.00 117.34 ? 63  GLY U CA   1 
ATOM   399  C C    . GLY A  1 63  ? 116.849 122.411 74.871  1.00 117.68 ? 63  GLY U C    1 
ATOM   400  O O    . GLY A  1 63  ? 116.874 122.789 73.697  1.00 119.37 ? 63  GLY U O    1 
ATOM   401  N N    . HIS A  1 64  ? 117.962 122.262 75.587  1.00 116.55 ? 64  HIS U N    1 
ATOM   402  C CA   . HIS A  1 64  ? 119.278 122.628 75.080  1.00 116.97 ? 64  HIS U CA   1 
ATOM   403  C C    . HIS A  1 64  ? 120.076 121.436 74.569  1.00 116.15 ? 64  HIS U C    1 
ATOM   404  O O    . HIS A  1 64  ? 121.287 121.561 74.358  1.00 113.42 ? 64  HIS U O    1 
ATOM   405  C CB   . HIS A  1 64  ? 120.075 123.375 76.154  1.00 114.89 ? 64  HIS U CB   1 
ATOM   406  C CG   . HIS A  1 64  ? 119.372 124.581 76.693  1.00 114.51 ? 64  HIS U CG   1 
ATOM   407  N ND1  . HIS A  1 64  ? 118.439 124.512 77.703  1.00 115.15 ? 64  HIS U ND1  1 
ATOM   408  C CD2  . HIS A  1 64  ? 119.464 125.888 76.358  1.00 114.35 ? 64  HIS U CD2  1 
ATOM   409  C CE1  . HIS A  1 64  ? 117.990 125.723 77.969  1.00 114.61 ? 64  HIS U CE1  1 
ATOM   410  N NE2  . HIS A  1 64  ? 118.597 126.578 77.166  1.00 116.31 ? 64  HIS U NE2  1 
ATOM   411  N N    . GLN A  1 65  ? 119.427 120.293 74.357  1.00 124.97 ? 65  GLN U N    1 
ATOM   412  C CA   . GLN A  1 65  ? 120.062 119.088 73.823  1.00 123.36 ? 65  GLN U CA   1 
ATOM   413  C C    . GLN A  1 65  ? 121.437 118.845 74.437  1.00 121.35 ? 65  GLN U C    1 
ATOM   414  O O    . GLN A  1 65  ? 122.429 118.604 73.746  1.00 118.91 ? 65  GLN U O    1 
ATOM   415  C CB   . GLN A  1 65  ? 120.157 119.155 72.299  1.00 122.32 ? 65  GLN U CB   1 
ATOM   416  C CG   . GLN A  1 65  ? 120.951 120.338 71.771  1.00 123.03 ? 65  GLN U CG   1 
ATOM   417  C CD   . GLN A  1 65  ? 120.858 120.480 70.266  1.00 125.34 ? 65  GLN U CD   1 
ATOM   418  O OE1  . GLN A  1 65  ? 120.118 119.751 69.607  1.00 125.31 ? 65  GLN U OE1  1 
ATOM   419  N NE2  . GLN A  1 65  ? 121.615 121.420 69.713  1.00 124.53 ? 65  GLN U NE2  1 
ATOM   420  N N    . LEU A  1 66  ? 121.494 118.918 75.766  1.00 117.56 ? 66  LEU U N    1 
ATOM   421  C CA   . LEU A  1 66  ? 122.687 118.566 76.512  1.00 116.30 ? 66  LEU U CA   1 
ATOM   422  C C    . LEU A  1 66  ? 122.681 117.069 76.814  1.00 116.29 ? 66  LEU U C    1 
ATOM   423  O O    . LEU A  1 66  ? 121.784 116.331 76.408  1.00 119.84 ? 66  LEU U O    1 
ATOM   424  C CB   . LEU A  1 66  ? 122.783 119.385 77.798  1.00 113.65 ? 66  LEU U CB   1 
ATOM   425  C CG   . LEU A  1 66  ? 123.163 120.859 77.659  1.00 114.55 ? 66  LEU U CG   1 
ATOM   426  C CD1  . LEU A  1 66  ? 122.755 121.629 78.902  1.00 115.48 ? 66  LEU U CD1  1 
ATOM   427  C CD2  . LEU A  1 66  ? 124.652 121.003 77.408  1.00 115.79 ? 66  LEU U CD2  1 
ATOM   428  N N    . SER A  1 67  ? 123.694 116.615 77.539  1.00 118.50 ? 67  SER U N    1 
ATOM   429  C CA   . SER A  1 67  ? 123.754 115.243 78.008  1.00 119.25 ? 67  SER U CA   1 
ATOM   430  C C    . SER A  1 67  ? 123.333 115.199 79.475  1.00 120.95 ? 67  SER U C    1 
ATOM   431  O O    . SER A  1 67  ? 122.891 116.200 80.045  1.00 122.88 ? 67  SER U O    1 
ATOM   432  C CB   . SER A  1 67  ? 125.157 114.668 77.796  1.00 119.97 ? 67  SER U CB   1 
ATOM   433  O OG   . SER A  1 67  ? 125.246 113.347 78.294  1.00 120.25 ? 67  SER U OG   1 
ATOM   434  N N    . ARG A  1 68  ? 123.464 114.031 80.100  1.00 120.96 ? 68  ARG U N    1 
ATOM   435  C CA   . ARG A  1 68  ? 123.127 113.894 81.511  1.00 120.28 ? 68  ARG U CA   1 
ATOM   436  C C    . ARG A  1 68  ? 124.339 113.898 82.431  1.00 119.29 ? 68  ARG U C    1 
ATOM   437  O O    . ARG A  1 68  ? 124.230 114.359 83.572  1.00 119.18 ? 68  ARG U O    1 
ATOM   438  C CB   . ARG A  1 68  ? 122.327 112.604 81.742  1.00 120.43 ? 68  ARG U CB   1 
ATOM   439  C CG   . ARG A  1 68  ? 121.723 112.500 83.131  1.00 121.79 ? 68  ARG U CG   1 
ATOM   440  C CD   . ARG A  1 68  ? 120.771 113.654 83.402  1.00 120.71 ? 68  ARG U CD   1 
ATOM   441  N NE   . ARG A  1 68  ? 119.557 113.571 82.600  1.00 120.19 ? 68  ARG U NE   1 
ATOM   442  C CZ   . ARG A  1 68  ? 118.428 113.007 83.009  1.00 120.57 ? 68  ARG U CZ   1 
ATOM   443  N NH1  . ARG A  1 68  ? 118.321 112.467 84.211  1.00 121.24 ? 68  ARG U NH1  1 
ATOM   444  N NH2  . ARG A  1 68  ? 117.381 112.986 82.191  1.00 118.01 ? 68  ARG U NH2  1 
ATOM   445  N N    . ASP A  1 69  ? 125.490 113.402 81.973  1.00 120.35 ? 69  ASP U N    1 
ATOM   446  C CA   . ASP A  1 69  ? 126.673 113.370 82.824  1.00 120.57 ? 69  ASP U CA   1 
ATOM   447  C C    . ASP A  1 69  ? 127.316 114.744 82.947  1.00 122.35 ? 69  ASP U C    1 
ATOM   448  O O    . ASP A  1 69  ? 127.839 115.104 84.010  1.00 123.85 ? 69  ASP U O    1 
ATOM   449  C CB   . ASP A  1 69  ? 127.688 112.359 82.284  1.00 122.89 ? 69  ASP U CB   1 
ATOM   450  C CG   . ASP A  1 69  ? 127.163 110.940 82.317  1.00 126.75 ? 69  ASP U CG   1 
ATOM   451  O OD1  . ASP A  1 69  ? 126.259 110.656 83.130  1.00 126.01 ? 69  ASP U OD1  1 
ATOM   452  O OD2  . ASP A  1 69  ? 127.658 110.102 81.531  1.00 127.92 ? 69  ASP U OD2  1 
ATOM   453  N N    . GLU A  1 70  ? 127.286 115.532 81.870  1.00 113.14 ? 70  GLU U N    1 
ATOM   454  C CA   . GLU A  1 70  ? 127.913 116.849 81.907  1.00 112.51 ? 70  GLU U CA   1 
ATOM   455  C C    . GLU A  1 70  ? 127.216 117.748 82.915  1.00 114.06 ? 70  GLU U C    1 
ATOM   456  O O    . GLU A  1 70  ? 127.874 118.493 83.655  1.00 113.12 ? 70  GLU U O    1 
ATOM   457  C CB   . GLU A  1 70  ? 127.898 117.470 80.513  1.00 111.09 ? 70  GLU U CB   1 
ATOM   458  C CG   . GLU A  1 70  ? 128.509 116.583 79.448  1.00 112.86 ? 70  GLU U CG   1 
ATOM   459  C CD   . GLU A  1 70  ? 128.519 117.233 78.083  1.00 115.61 ? 70  GLU U CD   1 
ATOM   460  O OE1  . GLU A  1 70  ? 128.126 118.410 77.981  1.00 119.79 ? 70  GLU U OE1  1 
ATOM   461  O OE2  . GLU A  1 70  ? 128.920 116.563 77.106  1.00 114.48 ? 70  GLU U OE2  1 
ATOM   462  N N    . LEU A  1 71  ? 125.883 117.705 82.954  1.00 101.54 ? 71  LEU U N    1 
ATOM   463  C CA   . LEU A  1 71  ? 125.161 118.467 83.963  1.00 98.17  ? 71  LEU U CA   1 
ATOM   464  C C    . LEU A  1 71  ? 125.494 117.982 85.365  1.00 98.27  ? 71  LEU U C    1 
ATOM   465  O O    . LEU A  1 71  ? 125.543 118.786 86.302  1.00 100.43 ? 71  LEU U O    1 
ATOM   466  C CB   . LEU A  1 71  ? 123.658 118.386 83.707  1.00 94.60  ? 71  LEU U CB   1 
ATOM   467  C CG   . LEU A  1 71  ? 123.163 119.096 82.446  1.00 95.09  ? 71  LEU U CG   1 
ATOM   468  C CD1  . LEU A  1 71  ? 121.687 118.832 82.229  1.00 96.45  ? 71  LEU U CD1  1 
ATOM   469  C CD2  . LEU A  1 71  ? 123.428 120.587 82.545  1.00 98.18  ? 71  LEU U CD2  1 
ATOM   470  N N    . ARG A  1 72  ? 125.741 116.681 85.533  1.00 100.87 ? 72  ARG U N    1 
ATOM   471  C CA   . ARG A  1 72  ? 126.148 116.178 86.840  1.00 100.65 ? 72  ARG U CA   1 
ATOM   472  C C    . ARG A  1 72  ? 127.496 116.753 87.259  1.00 104.81 ? 72  ARG U C    1 
ATOM   473  O O    . ARG A  1 72  ? 127.676 117.158 88.412  1.00 110.39 ? 72  ARG U O    1 
ATOM   474  C CB   . ARG A  1 72  ? 126.199 114.651 86.832  1.00 104.10 ? 72  ARG U CB   1 
ATOM   475  C CG   . ARG A  1 72  ? 124.849 113.982 86.642  1.00 108.43 ? 72  ARG U CG   1 
ATOM   476  C CD   . ARG A  1 72  ? 124.679 112.803 87.591  1.00 108.31 ? 72  ARG U CD   1 
ATOM   477  N NE   . ARG A  1 72  ? 125.819 111.895 87.542  1.00 110.31 ? 72  ARG U NE   1 
ATOM   478  C CZ   . ARG A  1 72  ? 125.911 110.849 86.734  1.00 110.74 ? 72  ARG U CZ   1 
ATOM   479  N NH1  . ARG A  1 72  ? 124.945 110.541 85.886  1.00 109.41 ? 72  ARG U NH1  1 
ATOM   480  N NH2  . ARG A  1 72  ? 127.002 110.090 86.778  1.00 109.27 ? 72  ARG U NH2  1 
ATOM   481  N N    . GLY A  1 73  ? 128.454 116.808 86.335  1.00 93.85  ? 73  GLY U N    1 
ATOM   482  C CA   . GLY A  1 73  ? 129.739 117.410 86.661  1.00 94.87  ? 73  GLY U CA   1 
ATOM   483  C C    . GLY A  1 73  ? 129.624 118.892 86.964  1.00 96.88  ? 73  GLY U C    1 
ATOM   484  O O    . GLY A  1 73  ? 130.262 119.404 87.891  1.00 99.56  ? 73  GLY U O    1 
ATOM   485  N N    . PHE A  1 74  ? 128.793 119.600 86.197  1.00 77.33  ? 74  PHE U N    1 
ATOM   486  C CA   . PHE A  1 74  ? 128.559 121.013 86.460  1.00 72.04  ? 74  PHE U CA   1 
ATOM   487  C C    . PHE A  1 74  ? 127.963 121.222 87.846  1.00 73.76  ? 74  PHE U C    1 
ATOM   488  O O    . PHE A  1 74  ? 128.394 122.109 88.592  1.00 77.10  ? 74  PHE U O    1 
ATOM   489  C CB   . PHE A  1 74  ? 127.647 121.590 85.377  1.00 68.77  ? 74  PHE U CB   1 
ATOM   490  C CG   . PHE A  1 74  ? 127.488 123.078 85.438  1.00 71.60  ? 74  PHE U CG   1 
ATOM   491  C CD1  . PHE A  1 74  ? 128.549 123.914 85.154  1.00 72.35  ? 74  PHE U CD1  1 
ATOM   492  C CD2  . PHE A  1 74  ? 126.265 123.643 85.755  1.00 74.26  ? 74  PHE U CD2  1 
ATOM   493  C CE1  . PHE A  1 74  ? 128.402 125.284 85.204  1.00 74.01  ? 74  PHE U CE1  1 
ATOM   494  C CE2  . PHE A  1 74  ? 126.112 125.010 85.803  1.00 72.55  ? 74  PHE U CE2  1 
ATOM   495  C CZ   . PHE A  1 74  ? 127.181 125.831 85.528  1.00 72.85  ? 74  PHE U CZ   1 
ATOM   496  N N    . LEU A  1 75  ? 126.987 120.391 88.220  1.00 69.59  ? 75  LEU U N    1 
ATOM   497  C CA   . LEU A  1 75  ? 126.372 120.521 89.534  1.00 68.58  ? 75  LEU U CA   1 
ATOM   498  C C    . LEU A  1 75  ? 127.339 120.150 90.652  1.00 74.97  ? 75  LEU U C    1 
ATOM   499  O O    . LEU A  1 75  ? 127.272 120.734 91.737  1.00 80.38  ? 75  LEU U O    1 
ATOM   500  C CB   . LEU A  1 75  ? 125.113 119.657 89.605  1.00 68.97  ? 75  LEU U CB   1 
ATOM   501  C CG   . LEU A  1 75  ? 123.965 120.086 88.691  1.00 69.37  ? 75  LEU U CG   1 
ATOM   502  C CD1  . LEU A  1 75  ? 122.768 119.171 88.862  1.00 69.86  ? 75  LEU U CD1  1 
ATOM   503  C CD2  . LEU A  1 75  ? 123.580 121.529 88.952  1.00 71.62  ? 75  LEU U CD2  1 
ATOM   504  N N    . ARG A  1 76  ? 128.235 119.191 90.417  1.00 80.92  ? 76  ARG U N    1 
ATOM   505  C CA   . ARG A  1 76  ? 129.244 118.873 91.424  1.00 78.45  ? 76  ARG U CA   1 
ATOM   506  C C    . ARG A  1 76  ? 130.198 120.043 91.639  1.00 81.04  ? 76  ARG U C    1 
ATOM   507  O O    . ARG A  1 76  ? 130.528 120.395 92.783  1.00 80.85  ? 76  ARG U O    1 
ATOM   508  C CB   . ARG A  1 76  ? 130.015 117.622 91.008  1.00 75.64  ? 76  ARG U CB   1 
ATOM   509  C CG   . ARG A  1 76  ? 130.897 117.042 92.091  1.00 83.60  ? 76  ARG U CG   1 
ATOM   510  C CD   . ARG A  1 76  ? 131.761 115.916 91.550  1.00 87.26  ? 76  ARG U CD   1 
ATOM   511  N NE   . ARG A  1 76  ? 130.971 114.889 90.883  1.00 83.34  ? 76  ARG U NE   1 
ATOM   512  C CZ   . ARG A  1 76  ? 130.454 113.829 91.489  1.00 86.05  ? 76  ARG U CZ   1 
ATOM   513  N NH1  . ARG A  1 76  ? 130.620 113.627 92.786  1.00 86.14  ? 76  ARG U NH1  1 
ATOM   514  N NH2  . ARG A  1 76  ? 129.754 112.951 90.778  1.00 84.83  ? 76  ARG U NH2  1 
ATOM   515  N N    . HIS A  1 77  ? 130.630 120.676 90.546  1.00 77.40  ? 77  HIS U N    1 
ATOM   516  C CA   . HIS A  1 77  ? 131.455 121.872 90.676  1.00 71.77  ? 77  HIS U CA   1 
ATOM   517  C C    . HIS A  1 77  ? 130.715 122.967 91.428  1.00 75.16  ? 77  HIS U C    1 
ATOM   518  O O    . HIS A  1 77  ? 131.298 123.661 92.267  1.00 77.84  ? 77  HIS U O    1 
ATOM   519  C CB   . HIS A  1 77  ? 131.881 122.372 89.296  1.00 73.37  ? 77  HIS U CB   1 
ATOM   520  C CG   . HIS A  1 77  ? 132.919 121.522 88.633  1.00 77.42  ? 77  HIS U CG   1 
ATOM   521  N ND1  . HIS A  1 77  ? 133.294 121.695 87.319  1.00 78.03  ? 77  HIS U ND1  1 
ATOM   522  C CD2  . HIS A  1 77  ? 133.661 120.494 89.104  1.00 78.57  ? 77  HIS U CD2  1 
ATOM   523  C CE1  . HIS A  1 77  ? 134.222 120.810 87.009  1.00 77.65  ? 77  HIS U CE1  1 
ATOM   524  N NE2  . HIS A  1 77  ? 134.465 120.067 88.073  1.00 80.20  ? 77  HIS U NE2  1 
ATOM   525  N N    . TYR A  1 78  ? 129.424 123.135 91.144  1.00 78.44  ? 78  TYR U N    1 
ATOM   526  C CA   . TYR A  1 78  ? 128.654 124.160 91.842  1.00 73.22  ? 78  TYR U CA   1 
ATOM   527  C C    . TYR A  1 78  ? 128.503 123.834 93.323  1.00 73.18  ? 78  TYR U C    1 
ATOM   528  O O    . TYR A  1 78  ? 128.488 124.741 94.158  1.00 81.91  ? 78  TYR U O    1 
ATOM   529  C CB   . TYR A  1 78  ? 127.281 124.340 91.200  1.00 74.56  ? 78  TYR U CB   1 
ATOM   530  C CG   . TYR A  1 78  ? 126.467 125.418 91.873  1.00 71.22  ? 78  TYR U CG   1 
ATOM   531  C CD1  . TYR A  1 78  ? 126.845 126.751 91.787  1.00 72.97  ? 78  TYR U CD1  1 
ATOM   532  C CD2  . TYR A  1 78  ? 125.335 125.104 92.608  1.00 70.56  ? 78  TYR U CD2  1 
ATOM   533  C CE1  . TYR A  1 78  ? 126.113 127.737 92.405  1.00 72.61  ? 78  TYR U CE1  1 
ATOM   534  C CE2  . TYR A  1 78  ? 124.597 126.088 93.227  1.00 77.19  ? 78  TYR U CE2  1 
ATOM   535  C CZ   . TYR A  1 78  ? 124.991 127.403 93.122  1.00 78.62  ? 78  TYR U CZ   1 
ATOM   536  O OH   . TYR A  1 78  ? 124.257 128.390 93.737  1.00 84.13  ? 78  TYR U OH   1 
ATOM   537  N N    . GLU A  1 79  ? 128.365 122.556 93.669  1.00 78.87  ? 79  GLU U N    1 
ATOM   538  C CA   . GLU A  1 79  ? 128.311 122.185 95.080  1.00 79.21  ? 79  GLU U CA   1 
ATOM   539  C C    . GLU A  1 79  ? 129.612 122.539 95.786  1.00 82.67  ? 79  GLU U C    1 
ATOM   540  O O    . GLU A  1 79  ? 129.597 123.098 96.891  1.00 83.67  ? 79  GLU U O    1 
ATOM   541  C CB   . GLU A  1 79  ? 128.016 120.694 95.227  1.00 83.11  ? 79  GLU U CB   1 
ATOM   542  C CG   . GLU A  1 79  ? 126.586 120.303 94.906  1.00 88.13  ? 79  GLU U CG   1 
ATOM   543  C CD   . GLU A  1 79  ? 126.300 118.851 95.221  1.00 91.36  ? 79  GLU U CD   1 
ATOM   544  O OE1  . GLU A  1 79  ? 127.226 118.146 95.674  1.00 90.26  ? 79  GLU U OE1  1 
ATOM   545  O OE2  . GLU A  1 79  ? 125.150 118.410 95.015  1.00 94.98  ? 79  GLU U OE2  1 
ATOM   546  N N    . GLU A  1 80  ? 130.746 122.248 95.151  1.00 88.92  ? 80  GLU U N    1 
ATOM   547  C CA   . GLU A  1 80  ? 132.024 122.641 95.747  1.00 82.50  ? 80  GLU U CA   1 
ATOM   548  C C    . GLU A  1 80  ? 132.112 124.154 95.910  1.00 81.12  ? 80  GLU U C    1 
ATOM   549  O O    . GLU A  1 80  ? 132.553 124.656 96.954  1.00 77.94  ? 80  GLU U O    1 
ATOM   550  C CB   . GLU A  1 80  ? 133.181 122.114 94.899  1.00 82.40  ? 80  GLU U CB   1 
ATOM   551  C CG   . GLU A  1 80  ? 134.548 122.442 95.456  1.00 85.18  ? 80  GLU U CG   1 
ATOM   552  C CD   . GLU A  1 80  ? 135.671 121.879 94.608  1.00 91.22  ? 80  GLU U CD   1 
ATOM   553  O OE1  . GLU A  1 80  ? 135.471 120.813 93.991  1.00 91.77  ? 80  GLU U OE1  1 
ATOM   554  O OE2  . GLU A  1 80  ? 136.753 122.503 94.560  1.00 92.95  ? 80  GLU U OE2  1 
ATOM   555  N N    . ALA A  1 81  ? 131.669 124.898 94.893  1.00 80.99  ? 81  ALA U N    1 
ATOM   556  C CA   . ALA A  1 81  ? 131.719 126.354 94.969  1.00 73.52  ? 81  ALA U CA   1 
ATOM   557  C C    . ALA A  1 81  ? 130.834 126.879 96.092  1.00 72.35  ? 81  ALA U C    1 
ATOM   558  O O    . ALA A  1 81  ? 131.236 127.772 96.842  1.00 77.39  ? 81  ALA U O    1 
ATOM   559  C CB   . ALA A  1 81  ? 131.308 126.963 93.632  1.00 77.02  ? 81  ALA U CB   1 
ATOM   560  N N    . THR A  1 82  ? 129.623 126.333 96.227  1.00 83.61  ? 82  THR U N    1 
ATOM   561  C CA   . THR A  1 82  ? 128.726 126.804 97.274  1.00 83.98  ? 82  THR U CA   1 
ATOM   562  C C    . THR A  1 82  ? 129.210 126.375 98.646  1.00 84.94  ? 82  THR U C    1 
ATOM   563  O O    . THR A  1 82  ? 128.807 126.972 99.649  1.00 85.50  ? 82  THR U O    1 
ATOM   564  C CB   . THR A  1 82  ? 127.308 126.284 97.042  1.00 82.59  ? 82  THR U CB   1 
ATOM   565  O OG1  . THR A  1 82  ? 126.367 127.181 97.641  1.00 90.36  ? 82  THR U OG1  1 
ATOM   566  C CG2  . THR A  1 82  ? 127.143 124.909 97.663  1.00 81.06  ? 82  THR U CG2  1 
ATOM   567  N N    . ARG A  1 83  ? 130.075 125.361 98.709  1.00 86.87  ? 83  ARG U N    1 
ATOM   568  C CA   . ARG A  1 83  ? 130.671 125.013 99.989  1.00 82.88  ? 83  ARG U CA   1 
ATOM   569  C C    . ARG A  1 83  ? 131.759 126.020 100.331 1.00 80.66  ? 83  ARG U C    1 
ATOM   570  O O    . ARG A  1 83  ? 131.934 126.381 101.499 1.00 80.61  ? 83  ARG U O    1 
ATOM   571  C CB   . ARG A  1 83  ? 131.229 123.592 99.957  1.00 85.94  ? 83  ARG U CB   1 
ATOM   572  C CG   . ARG A  1 83  ? 131.752 123.121 101.307 1.00 83.74  ? 83  ARG U CG   1 
ATOM   573  C CD   . ARG A  1 83  ? 132.457 121.777 101.217 1.00 85.30  ? 83  ARG U CD   1 
ATOM   574  N NE   . ARG A  1 83  ? 131.662 120.768 100.528 1.00 92.71  ? 83  ARG U NE   1 
ATOM   575  C CZ   . ARG A  1 83  ? 132.030 120.157 99.412  1.00 93.32  ? 83  ARG U CZ   1 
ATOM   576  N NH1  . ARG A  1 83  ? 133.200 120.400 98.844  1.00 89.46  ? 83  ARG U NH1  1 
ATOM   577  N NH2  . ARG A  1 83  ? 131.213 119.265 98.858  1.00 85.50  ? 83  ARG U NH2  1 
ATOM   578  N N    . ALA A  1 84  ? 132.495 126.482 99.316  1.00 83.75  ? 84  ALA U N    1 
ATOM   579  C CA   . ALA A  1 84  ? 133.527 127.487 99.547  1.00 76.38  ? 84  ALA U CA   1 
ATOM   580  C C    . ALA A  1 84  ? 132.929 128.807 100.015 1.00 73.53  ? 84  ALA U C    1 
ATOM   581  O O    . ALA A  1 84  ? 133.555 129.522 100.803 1.00 74.88  ? 84  ALA U O    1 
ATOM   582  C CB   . ALA A  1 84  ? 134.355 127.697 98.281  1.00 77.81  ? 84  ALA U CB   1 
ATOM   583  N N    . GLY A  1 85  ? 131.736 129.158 99.534  1.00 78.21  ? 85  GLY U N    1 
ATOM   584  C CA   . GLY A  1 85  ? 131.081 130.384 99.954  1.00 70.97  ? 85  GLY U CA   1 
ATOM   585  C C    . GLY A  1 85  ? 130.378 131.152 98.854  1.00 75.01  ? 85  GLY U C    1 
ATOM   586  O O    . GLY A  1 85  ? 129.792 132.206 99.108  1.00 75.21  ? 85  GLY U O    1 
ATOM   587  N N    . ILE A  1 86  ? 130.430 130.639 97.630  1.00 79.90  ? 86  ILE U N    1 
ATOM   588  C CA   . ILE A  1 86  ? 129.786 131.292 96.494  1.00 73.74  ? 86  ILE U CA   1 
ATOM   589  C C    . ILE A  1 86  ? 128.288 131.023 96.539  1.00 79.36  ? 86  ILE U C    1 
ATOM   590  O O    . ILE A  1 86  ? 127.850 129.914 96.856  1.00 85.24  ? 86  ILE U O    1 
ATOM   591  C CB   . ILE A  1 86  ? 130.401 130.800 95.172  1.00 68.68  ? 86  ILE U CB   1 
ATOM   592  C CG1  . ILE A  1 86  ? 131.696 131.556 94.870  1.00 75.92  ? 86  ILE U CG1  1 
ATOM   593  C CG2  . ILE A  1 86  ? 129.416 130.971 94.033  1.00 74.65  ? 86  ILE U CG2  1 
ATOM   594  C CD1  . ILE A  1 86  ? 131.489 133.020 94.582  1.00 79.53  ? 86  ILE U CD1  1 
ATOM   595  N N    . ARG A  1 87  ? 127.496 132.046 96.224  1.00 84.09  ? 87  ARG U N    1 
ATOM   596  C CA   . ARG A  1 87  ? 126.047 131.910 96.178  1.00 81.19  ? 87  ARG U CA   1 
ATOM   597  C C    . ARG A  1 87  ? 125.501 132.675 94.983  1.00 85.19  ? 87  ARG U C    1 
ATOM   598  O O    . ARG A  1 87  ? 126.144 133.585 94.453  1.00 91.14  ? 87  ARG U O    1 
ATOM   599  C CB   . ARG A  1 87  ? 125.392 132.395 97.474  1.00 80.38  ? 87  ARG U CB   1 
ATOM   600  C CG   . ARG A  1 87  ? 124.098 131.684 97.808  1.00 85.55  ? 87  ARG U CG   1 
ATOM   601  C CD   . ARG A  1 87  ? 123.808 131.743 99.298  1.00 89.95  ? 87  ARG U CD   1 
ATOM   602  N NE   . ARG A  1 87  ? 124.934 131.263 100.087 1.00 88.50  ? 87  ARG U NE   1 
ATOM   603  C CZ   . ARG A  1 87  ? 125.157 129.991 100.377 1.00 86.29  ? 87  ARG U CZ   1 
ATOM   604  N NH1  . ARG A  1 87  ? 124.348 129.033 99.952  1.00 86.74  ? 87  ARG U NH1  1 
ATOM   605  N NH2  . ARG A  1 87  ? 126.217 129.669 101.111 1.00 82.63  ? 87  ARG U NH2  1 
ATOM   606  N N    . VAL A  1 88  ? 124.293 132.296 94.561  1.00 97.78  ? 88  VAL U N    1 
ATOM   607  C CA   . VAL A  1 88  ? 123.694 132.908 93.379  1.00 100.24 ? 88  VAL U CA   1 
ATOM   608  C C    . VAL A  1 88  ? 123.411 134.386 93.614  1.00 101.56 ? 88  VAL U C    1 
ATOM   609  O O    . VAL A  1 88  ? 123.668 135.228 92.745  1.00 101.22 ? 88  VAL U O    1 
ATOM   610  C CB   . VAL A  1 88  ? 122.418 132.149 92.970  1.00 99.15  ? 88  VAL U CB   1 
ATOM   611  C CG1  . VAL A  1 88  ? 121.457 133.085 92.259  1.00 96.64  ? 88  VAL U CG1  1 
ATOM   612  C CG2  . VAL A  1 88  ? 122.769 130.974 92.079  1.00 99.42  ? 88  VAL U CG2  1 
ATOM   613  N N    . ASP A  1 89  ? 122.875 134.727 94.782  1.00 109.50 ? 89  ASP U N    1 
ATOM   614  C CA   . ASP A  1 89  ? 122.652 136.117 95.144  1.00 107.84 ? 89  ASP U CA   1 
ATOM   615  C C    . ASP A  1 89  ? 123.900 136.699 95.794  1.00 111.15 ? 89  ASP U C    1 
ATOM   616  O O    . ASP A  1 89  ? 124.691 135.984 96.416  1.00 114.29 ? 89  ASP U O    1 
ATOM   617  C CB   . ASP A  1 89  ? 121.461 136.248 96.092  1.00 107.29 ? 89  ASP U CB   1 
ATOM   618  C CG   . ASP A  1 89  ? 120.163 135.804 95.460  1.00 112.39 ? 89  ASP U CG   1 
ATOM   619  O OD1  . ASP A  1 89  ? 120.011 135.975 94.233  1.00 114.22 ? 89  ASP U OD1  1 
ATOM   620  O OD2  . ASP A  1 89  ? 119.290 135.285 96.191  1.00 116.35 ? 89  ASP U OD2  1 
ATOM   621  N N    . ASN A  1 90  ? 124.074 138.008 95.644  1.00 104.08 ? 90  ASN U N    1 
ATOM   622  C CA   . ASN A  1 90  ? 125.228 138.668 96.232  1.00 103.47 ? 90  ASN U CA   1 
ATOM   623  C C    . ASN A  1 90  ? 125.182 138.547 97.750  1.00 103.58 ? 90  ASN U C    1 
ATOM   624  O O    . ASN A  1 90  ? 124.156 138.822 98.376  1.00 107.59 ? 90  ASN U O    1 
ATOM   625  C CB   . ASN A  1 90  ? 125.258 140.138 95.819  1.00 104.91 ? 90  ASN U CB   1 
ATOM   626  C CG   . ASN A  1 90  ? 125.198 140.324 94.317  1.00 105.86 ? 90  ASN U CG   1 
ATOM   627  O OD1  . ASN A  1 90  ? 124.743 139.441 93.591  1.00 107.46 ? 90  ASN U OD1  1 
ATOM   628  N ND2  . ASN A  1 90  ? 125.651 141.476 93.844  1.00 103.55 ? 90  ASN U ND2  1 
ATOM   629  N N    . VAL A  1 91  ? 126.302 138.132 98.337  1.00 84.62  ? 91  VAL U N    1 
ATOM   630  C CA   . VAL A  1 91  ? 126.418 137.979 99.778  1.00 84.34  ? 91  VAL U CA   1 
ATOM   631  C C    . VAL A  1 91  ? 127.718 138.618 100.241 1.00 84.76  ? 91  VAL U C    1 
ATOM   632  O O    . VAL A  1 91  ? 128.640 138.848 99.458  1.00 88.18  ? 91  VAL U O    1 
ATOM   633  C CB   . VAL A  1 91  ? 126.358 136.499 100.216 1.00 79.49  ? 91  VAL U CB   1 
ATOM   634  C CG1  . VAL A  1 91  ? 124.990 135.916 99.932  1.00 80.56  ? 91  VAL U CG1  1 
ATOM   635  C CG2  . VAL A  1 91  ? 127.436 135.698 99.515  1.00 82.57  ? 91  VAL U CG2  1 
ATOM   636  N N    . ARG A  1 92  ? 127.777 138.909 101.537 1.00 73.45  ? 92  ARG U N    1 
ATOM   637  C CA   . ARG A  1 92  ? 128.974 139.490 102.117 1.00 71.23  ? 92  ARG U CA   1 
ATOM   638  C C    . ARG A  1 92  ? 130.122 138.482 102.071 1.00 77.73  ? 92  ARG U C    1 
ATOM   639  O O    . ARG A  1 92  ? 129.901 137.276 102.190 1.00 81.26  ? 92  ARG U O    1 
ATOM   640  C CB   . ARG A  1 92  ? 128.715 139.917 103.558 1.00 70.94  ? 92  ARG U CB   1 
ATOM   641  C CG   . ARG A  1 92  ? 128.389 138.763 104.488 1.00 73.09  ? 92  ARG U CG   1 
ATOM   642  C CD   . ARG A  1 92  ? 127.937 139.248 105.855 1.00 73.43  ? 92  ARG U CD   1 
ATOM   643  N NE   . ARG A  1 92  ? 128.961 140.030 106.537 1.00 75.30  ? 92  ARG U NE   1 
ATOM   644  C CZ   . ARG A  1 92  ? 128.853 140.477 107.780 1.00 75.58  ? 92  ARG U CZ   1 
ATOM   645  N NH1  . ARG A  1 92  ? 127.782 140.226 108.513 1.00 69.70  ? 92  ARG U NH1  1 
ATOM   646  N NH2  . ARG A  1 92  ? 129.843 141.194 108.300 1.00 76.17  ? 92  ARG U NH2  1 
ATOM   647  N N    . PRO A  1 93  ? 131.352 138.953 101.905 1.00 73.71  ? 93  PRO U N    1 
ATOM   648  C CA   . PRO A  1 93  ? 132.487 138.031 101.872 1.00 69.22  ? 93  PRO U CA   1 
ATOM   649  C C    . PRO A  1 93  ? 132.696 137.348 103.214 1.00 69.16  ? 93  PRO U C    1 
ATOM   650  O O    . PRO A  1 93  ? 132.413 137.908 104.274 1.00 71.87  ? 93  PRO U O    1 
ATOM   651  C CB   . PRO A  1 93  ? 133.673 138.935 101.521 1.00 63.75  ? 93  PRO U CB   1 
ATOM   652  C CG   . PRO A  1 93  ? 133.249 140.292 101.960 1.00 66.64  ? 93  PRO U CG   1 
ATOM   653  C CD   . PRO A  1 93  ? 131.771 140.352 101.720 1.00 71.97  ? 93  PRO U CD   1 
ATOM   654  N N    . ARG A  1 94  ? 133.192 136.117 103.151 1.00 72.00  ? 94  ARG U N    1 
ATOM   655  C CA   . ARG A  1 94  ? 133.571 135.379 104.342 1.00 68.83  ? 94  ARG U CA   1 
ATOM   656  C C    . ARG A  1 94  ? 135.008 135.700 104.740 1.00 77.75  ? 94  ARG U C    1 
ATOM   657  O O    . ARG A  1 94  ? 135.814 136.177 103.937 1.00 88.16  ? 94  ARG U O    1 
ATOM   658  C CB   . ARG A  1 94  ? 133.427 133.873 104.116 1.00 67.97  ? 94  ARG U CB   1 
ATOM   659  C CG   . ARG A  1 94  ? 132.040 133.322 104.360 1.00 65.93  ? 94  ARG U CG   1 
ATOM   660  C CD   . ARG A  1 94  ? 131.110 133.600 103.204 1.00 64.69  ? 94  ARG U CD   1 
ATOM   661  N NE   . ARG A  1 94  ? 129.750 133.172 103.506 1.00 66.87  ? 94  ARG U NE   1 
ATOM   662  C CZ   . ARG A  1 94  ? 128.825 133.952 104.045 1.00 71.44  ? 94  ARG U CZ   1 
ATOM   663  N NH1  . ARG A  1 94  ? 129.070 135.217 104.335 1.00 72.81  ? 94  ARG U NH1  1 
ATOM   664  N NH2  . ARG A  1 94  ? 127.620 133.448 104.299 1.00 76.07  ? 94  ARG U NH2  1 
ATOM   665  N N    . TRP A  1 95  ? 135.371 135.263 105.952 1.00 56.73  ? 95  TRP U N    1 
ATOM   666  C CA   . TRP A  1 95  ? 136.786 135.350 106.416 1.00 56.33  ? 95  TRP U CA   1 
ATOM   667  C C    . TRP A  1 95  ? 137.343 136.774 106.430 1.00 56.09  ? 95  TRP U C    1 
ATOM   668  O O    . TRP A  1 95  ? 138.575 136.919 106.311 1.00 69.73  ? 95  TRP U O    1 
ATOM   669  C CB   . TRP A  1 95  ? 137.661 134.377 105.612 1.00 50.80  ? 95  TRP U CB   1 
ATOM   670  C CG   . TRP A  1 95  ? 137.243 132.953 105.816 1.00 54.62  ? 95  TRP U CG   1 
ATOM   671  C CD1  . TRP A  1 95  ? 137.016 132.014 104.852 1.00 62.89  ? 95  TRP U CD1  1 
ATOM   672  C CD2  . TRP A  1 95  ? 136.975 132.307 107.074 1.00 56.75  ? 95  TRP U CD2  1 
ATOM   673  N NE1  . TRP A  1 95  ? 136.641 130.828 105.422 1.00 66.19  ? 95  TRP U NE1  1 
ATOM   674  C CE2  . TRP A  1 95  ? 136.608 130.976 106.784 1.00 58.35  ? 95  TRP U CE2  1 
ATOM   675  C CE3  . TRP A  1 95  ? 137.025 132.713 108.414 1.00 59.53  ? 95  TRP U CE3  1 
ATOM   676  C CZ2  . TRP A  1 95  ? 136.289 130.059 107.784 1.00 54.05  ? 95  TRP U CZ2  1 
ATOM   677  C CZ3  . TRP A  1 95  ? 136.707 131.806 109.400 1.00 58.60  ? 95  TRP U CZ3  1 
ATOM   678  C CH2  . TRP A  1 95  ? 136.343 130.497 109.087 1.00 58.42  ? 95  TRP U CH2  1 
ATOM   679  N N    . ASP A  1 96  ? 136.482 137.777 106.582 1.00 63.29  ? 96  ASP U N    1 
ATOM   680  C CA   . ASP A  1 96  ? 137.008 139.156 106.760 1.00 66.81  ? 96  ASP U CA   1 
ATOM   681  C C    . ASP A  1 96  ? 136.850 139.463 108.251 1.00 77.30  ? 96  ASP U C    1 
ATOM   682  O O    . ASP A  1 96  ? 136.305 138.597 108.961 1.00 79.27  ? 96  ASP U O    1 
ATOM   683  C CB   . ASP A  1 96  ? 136.360 140.139 105.785 1.00 69.33  ? 96  ASP U CB   1 
ATOM   684  C CG   . ASP A  1 96  ? 134.888 140.369 106.053 1.00 80.75  ? 96  ASP U CG   1 
ATOM   685  O OD1  . ASP A  1 96  ? 134.179 139.389 106.356 1.00 85.74  ? 96  ASP U OD1  1 
ATOM   686  O OD2  . ASP A  1 96  ? 134.473 141.527 105.952 1.00 80.02  ? 96  ASP U OD2  1 
ATOM   687  N N    . PHE A  1 97  ? 137.289 140.632 108.721 1.00 70.42  ? 97  PHE U N    1 
ATOM   688  C CA   . PHE A  1 97  ? 137.259 140.855 110.161 1.00 66.32  ? 97  PHE U CA   1 
ATOM   689  C C    . PHE A  1 97  ? 135.845 140.722 110.712 1.00 72.63  ? 97  PHE U C    1 
ATOM   690  O O    . PHE A  1 97  ? 135.631 140.085 111.748 1.00 79.74  ? 97  PHE U O    1 
ATOM   691  C CB   . PHE A  1 97  ? 137.842 142.225 110.505 1.00 67.24  ? 97  PHE U CB   1 
ATOM   692  C CG   . PHE A  1 97  ? 138.117 142.407 111.969 1.00 70.90  ? 97  PHE U CG   1 
ATOM   693  C CD1  . PHE A  1 97  ? 139.335 142.035 112.506 1.00 70.40  ? 97  PHE U CD1  1 
ATOM   694  C CD2  . PHE A  1 97  ? 137.152 142.927 112.809 1.00 73.98  ? 97  PHE U CD2  1 
ATOM   695  C CE1  . PHE A  1 97  ? 139.586 142.193 113.850 1.00 71.73  ? 97  PHE U CE1  1 
ATOM   696  C CE2  . PHE A  1 97  ? 137.402 143.085 114.156 1.00 69.03  ? 97  PHE U CE2  1 
ATOM   697  C CZ   . PHE A  1 97  ? 138.620 142.719 114.675 1.00 70.55  ? 97  PHE U CZ   1 
ATOM   698  N N    . THR A  1 98  ? 134.860 141.286 110.012 1.00 66.45  ? 98  THR U N    1 
ATOM   699  C CA   . THR A  1 98  ? 133.486 141.208 110.492 1.00 72.02  ? 98  THR U CA   1 
ATOM   700  C C    . THR A  1 98  ? 132.928 139.797 110.347 1.00 75.76  ? 98  THR U C    1 
ATOM   701  O O    . THR A  1 98  ? 132.233 139.301 111.242 1.00 77.57  ? 98  THR U O    1 
ATOM   702  C CB   . THR A  1 98  ? 132.615 142.215 109.741 1.00 67.62  ? 98  THR U CB   1 
ATOM   703  O OG1  . THR A  1 98  ? 132.483 141.807 108.375 1.00 74.12  ? 98  THR U OG1  1 
ATOM   704  C CG2  . THR A  1 98  ? 133.252 143.590 109.784 1.00 62.55  ? 98  THR U CG2  1 
ATOM   705  N N    . GLY A  1 99  ? 133.219 139.133 109.228 1.00 67.81  ? 99  GLY U N    1 
ATOM   706  C CA   . GLY A  1 99  ? 132.771 137.764 109.065 1.00 66.98  ? 99  GLY U CA   1 
ATOM   707  C C    . GLY A  1 99  ? 133.392 136.833 110.088 1.00 71.89  ? 99  GLY U C    1 
ATOM   708  O O    . GLY A  1 99  ? 132.723 135.945 110.622 1.00 81.28  ? 99  GLY U O    1 
ATOM   709  N N    . ALA A  1 100 ? 134.677 137.027 110.383 1.00 54.85  ? 100 ALA U N    1 
ATOM   710  C CA   . ALA A  1 100 ? 135.324 136.231 111.419 1.00 55.72  ? 100 ALA U CA   1 
ATOM   711  C C    . ALA A  1 100 ? 134.734 136.518 112.793 1.00 64.41  ? 100 ALA U C    1 
ATOM   712  O O    . ALA A  1 100 ? 134.592 135.606 113.617 1.00 72.24  ? 100 ALA U O    1 
ATOM   713  C CB   . ALA A  1 100 ? 136.830 136.488 111.412 1.00 63.66  ? 100 ALA U CB   1 
ATOM   714  N N    . PHE A  1 101 ? 134.387 137.779 113.064 1.00 52.88  ? 101 PHE U N    1 
ATOM   715  C CA   . PHE A  1 101 ? 133.735 138.103 114.327 1.00 55.19  ? 101 PHE U CA   1 
ATOM   716  C C    . PHE A  1 101 ? 132.400 137.385 114.450 1.00 55.42  ? 101 PHE U C    1 
ATOM   717  O O    . PHE A  1 101 ? 132.089 136.802 115.497 1.00 61.62  ? 101 PHE U O    1 
ATOM   718  C CB   . PHE A  1 101 ? 133.549 139.616 114.436 1.00 53.96  ? 101 PHE U CB   1 
ATOM   719  C CG   . PHE A  1 101 ? 133.101 140.083 115.790 1.00 62.88  ? 101 PHE U CG   1 
ATOM   720  C CD1  . PHE A  1 101 ? 134.020 140.323 116.793 1.00 63.26  ? 101 PHE U CD1  1 
ATOM   721  C CD2  . PHE A  1 101 ? 131.759 140.282 116.057 1.00 61.82  ? 101 PHE U CD2  1 
ATOM   722  C CE1  . PHE A  1 101 ? 133.612 140.753 118.036 1.00 56.99  ? 101 PHE U CE1  1 
ATOM   723  C CE2  . PHE A  1 101 ? 131.347 140.712 117.299 1.00 56.38  ? 101 PHE U CE2  1 
ATOM   724  C CZ   . PHE A  1 101 ? 132.274 140.946 118.289 1.00 55.84  ? 101 PHE U CZ   1 
ATOM   725  N N    . TYR A  1 102 ? 131.595 137.375 113.425 1.00 47.64  ? 102 TYR U N    1 
ATOM   726  C CA   . TYR A  1 102 ? 130.308 136.657 113.453 1.00 50.92  ? 102 TYR U CA   1 
ATOM   727  C C    . TYR A  1 102 ? 130.538 135.153 113.529 1.00 56.05  ? 102 TYR U C    1 
ATOM   728  O O    . TYR A  1 102 ? 129.726 134.521 114.132 1.00 63.42  ? 102 TYR U O    1 
ATOM   729  C CB   . TYR A  1 102 ? 129.533 137.083 112.215 1.00 54.95  ? 102 TYR U CB   1 
ATOM   730  C CG   . TYR A  1 102 ? 128.057 136.806 112.113 1.00 62.70  ? 102 TYR U CG   1 
ATOM   731  C CD1  . TYR A  1 102 ? 127.396 135.991 113.008 1.00 65.50  ? 102 TYR U CD1  1 
ATOM   732  C CD2  . TYR A  1 102 ? 127.322 137.359 111.084 1.00 57.74  ? 102 TYR U CD2  1 
ATOM   733  C CE1  . TYR A  1 102 ? 126.040 135.746 112.892 1.00 64.03  ? 102 TYR U CE1  1 
ATOM   734  C CE2  . TYR A  1 102 ? 125.968 137.124 110.950 1.00 54.98  ? 102 TYR U CE2  1 
ATOM   735  C CZ   . TYR A  1 102 ? 125.326 136.319 111.863 1.00 62.24  ? 102 TYR U CZ   1 
ATOM   736  O OH   . TYR A  1 102 ? 123.992 136.079 111.749 1.00 66.44  ? 102 TYR U OH   1 
ATOM   737  N N    . PHE A  1 103 ? 131.586 134.596 112.934 1.00 52.29  ? 103 PHE U N    1 
ATOM   738  C CA   . PHE A  1 103 ? 131.856 133.169 113.061 1.00 47.54  ? 103 PHE U CA   1 
ATOM   739  C C    . PHE A  1 103 ? 132.214 132.798 114.495 1.00 51.95  ? 103 PHE U C    1 
ATOM   740  O O    . PHE A  1 103 ? 131.683 131.829 115.049 1.00 62.81  ? 103 PHE U O    1 
ATOM   741  C CB   . PHE A  1 103 ? 132.977 132.764 112.105 1.00 52.22  ? 103 PHE U CB   1 
ATOM   742  C CG   . PHE A  1 103 ? 133.481 131.369 112.315 1.00 55.39  ? 103 PHE U CG   1 
ATOM   743  C CD1  . PHE A  1 103 ? 132.713 130.279 111.952 1.00 55.85  ? 103 PHE U CD1  1 
ATOM   744  C CD2  . PHE A  1 103 ? 134.727 131.148 112.868 1.00 58.04  ? 103 PHE U CD2  1 
ATOM   745  C CE1  . PHE A  1 103 ? 133.177 128.995 112.145 1.00 53.79  ? 103 PHE U CE1  1 
ATOM   746  C CE2  . PHE A  1 103 ? 135.195 129.867 113.061 1.00 58.69  ? 103 PHE U CE2  1 
ATOM   747  C CZ   . PHE A  1 103 ? 134.418 128.791 112.699 1.00 54.48  ? 103 PHE U CZ   1 
ATOM   748  N N    . VAL A  1 104 ? 133.120 133.557 115.118 1.00 49.51  ? 104 VAL U N    1 
ATOM   749  C CA   . VAL A  1 104 ? 133.510 133.227 116.485 1.00 42.93  ? 104 VAL U CA   1 
ATOM   750  C C    . VAL A  1 104 ? 132.349 133.452 117.444 1.00 49.73  ? 104 VAL U C    1 
ATOM   751  O O    . VAL A  1 104 ? 132.185 132.702 118.417 1.00 50.34  ? 104 VAL U O    1 
ATOM   752  C CB   . VAL A  1 104 ? 134.751 134.033 116.908 1.00 38.30  ? 104 VAL U CB   1 
ATOM   753  C CG1  . VAL A  1 104 ? 135.924 133.698 116.010 1.00 44.17  ? 104 VAL U CG1  1 
ATOM   754  C CG2  . VAL A  1 104 ? 134.455 135.518 116.873 1.00 47.13  ? 104 VAL U CG2  1 
ATOM   755  N N    . GLY A  1 105 ? 131.518 134.464 117.192 1.00 53.69  ? 105 GLY U N    1 
ATOM   756  C CA   . GLY A  1 105 ? 130.337 134.648 118.015 1.00 47.95  ? 105 GLY U CA   1 
ATOM   757  C C    . GLY A  1 105 ? 129.388 133.468 117.944 1.00 47.63  ? 105 GLY U C    1 
ATOM   758  O O    . GLY A  1 105 ? 128.805 133.066 118.953 1.00 48.06  ? 105 GLY U O    1 
ATOM   759  N N    . THR A  1 106 ? 129.222 132.891 116.753 1.00 58.12  ? 106 THR U N    1 
ATOM   760  C CA   . THR A  1 106 ? 128.388 131.695 116.644 1.00 50.46  ? 106 THR U CA   1 
ATOM   761  C C    . THR A  1 106 ? 129.057 130.486 117.282 1.00 51.91  ? 106 THR U C    1 
ATOM   762  O O    . THR A  1 106 ? 128.367 129.596 117.794 1.00 52.18  ? 106 THR U O    1 
ATOM   763  C CB   . THR A  1 106 ? 128.057 131.395 115.181 1.00 50.77  ? 106 THR U CB   1 
ATOM   764  O OG1  . THR A  1 106 ? 129.267 131.200 114.443 1.00 58.51  ? 106 THR U OG1  1 
ATOM   765  C CG2  . THR A  1 106 ? 127.271 132.537 114.565 1.00 52.70  ? 106 THR U CG2  1 
ATOM   766  N N    . VAL A  1 107 ? 130.388 130.422 117.255 1.00 50.99  ? 107 VAL U N    1 
ATOM   767  C CA   . VAL A  1 107 ? 131.086 129.262 117.800 1.00 42.88  ? 107 VAL U CA   1 
ATOM   768  C C    . VAL A  1 107 ? 130.993 129.234 119.322 1.00 50.00  ? 107 VAL U C    1 
ATOM   769  O O    . VAL A  1 107 ? 130.668 128.201 119.920 1.00 55.67  ? 107 VAL U O    1 
ATOM   770  C CB   . VAL A  1 107 ? 132.548 129.240 117.327 1.00 38.50  ? 107 VAL U CB   1 
ATOM   771  C CG1  . VAL A  1 107 ? 133.353 128.260 118.160 1.00 43.50  ? 107 VAL U CG1  1 
ATOM   772  C CG2  . VAL A  1 107 ? 132.620 128.872 115.860 1.00 48.76  ? 107 VAL U CG2  1 
ATOM   773  N N    . VAL A  1 108 ? 131.274 130.365 119.976 1.00 63.32  ? 108 VAL U N    1 
ATOM   774  C CA   . VAL A  1 108 ? 131.381 130.341 121.434 1.00 51.39  ? 108 VAL U CA   1 
ATOM   775  C C    . VAL A  1 108 ? 130.032 130.151 122.120 1.00 46.86  ? 108 VAL U C    1 
ATOM   776  O O    . VAL A  1 108 ? 129.996 129.746 123.286 1.00 50.03  ? 108 VAL U O    1 
ATOM   777  C CB   . VAL A  1 108 ? 132.058 131.620 121.957 1.00 43.86  ? 108 VAL U CB   1 
ATOM   778  C CG1  . VAL A  1 108 ? 133.482 131.711 121.440 1.00 49.22  ? 108 VAL U CG1  1 
ATOM   779  C CG2  . VAL A  1 108 ? 131.260 132.845 121.558 1.00 49.92  ? 108 VAL U CG2  1 
ATOM   780  N N    . SER A  1 109 ? 128.927 130.430 121.440 1.00 60.27  ? 109 SER U N    1 
ATOM   781  C CA   . SER A  1 109 ? 127.603 130.228 122.012 1.00 52.66  ? 109 SER U CA   1 
ATOM   782  C C    . SER A  1 109 ? 127.000 128.880 121.648 1.00 57.17  ? 109 SER U C    1 
ATOM   783  O O    . SER A  1 109 ? 125.858 128.604 122.029 1.00 61.93  ? 109 SER U O    1 
ATOM   784  C CB   . SER A  1 109 ? 126.661 131.352 121.576 1.00 48.84  ? 109 SER U CB   1 
ATOM   785  O OG   . SER A  1 109 ? 126.611 131.454 120.166 1.00 53.72  ? 109 SER U OG   1 
ATOM   786  N N    . THR A  1 110 ? 127.741 128.034 120.934 1.00 61.22  ? 110 THR U N    1 
ATOM   787  C CA   . THR A  1 110 ? 127.265 126.713 120.516 1.00 58.91  ? 110 THR U CA   1 
ATOM   788  C C    . THR A  1 110 ? 125.975 126.807 119.707 1.00 54.17  ? 110 THR U C    1 
ATOM   789  O O    . THR A  1 110 ? 125.065 125.994 119.863 1.00 64.76  ? 110 THR U O    1 
ATOM   790  C CB   . THR A  1 110 ? 127.072 125.785 121.717 1.00 60.42  ? 110 THR U CB   1 
ATOM   791  O OG1  . THR A  1 110 ? 126.075 126.329 122.590 1.00 64.46  ? 110 THR U OG1  1 
ATOM   792  C CG2  . THR A  1 110 ? 128.374 125.621 122.478 1.00 61.60  ? 110 THR U CG2  1 
ATOM   793  N N    . ILE A  1 111 ? 125.895 127.801 118.823 1.00 43.27  ? 111 ILE U N    1 
ATOM   794  C CA   . ILE A  1 111 ? 124.783 127.895 117.886 1.00 54.28  ? 111 ILE U CA   1 
ATOM   795  C C    . ILE A  1 111 ? 125.163 127.154 116.614 1.00 59.39  ? 111 ILE U C    1 
ATOM   796  O O    . ILE A  1 111 ? 124.509 126.178 116.230 1.00 63.88  ? 111 ILE U O    1 
ATOM   797  C CB   . ILE A  1 111 ? 124.405 129.355 117.586 1.00 57.99  ? 111 ILE U CB   1 
ATOM   798  C CG1  . ILE A  1 111 ? 123.840 130.031 118.836 1.00 55.67  ? 111 ILE U CG1  1 
ATOM   799  C CG2  . ILE A  1 111 ? 123.391 129.416 116.458 1.00 49.59  ? 111 ILE U CG2  1 
ATOM   800  C CD1  . ILE A  1 111 ? 123.385 131.451 118.607 1.00 48.42  ? 111 ILE U CD1  1 
ATOM   801  N N    . GLY A  1 112 ? 126.226 127.608 115.955 1.00 54.38  ? 112 GLY U N    1 
ATOM   802  C CA   . GLY A  1 112 ? 126.730 126.926 114.781 1.00 47.58  ? 112 GLY U CA   1 
ATOM   803  C C    . GLY A  1 112 ? 125.769 126.915 113.613 1.00 48.93  ? 112 GLY U C    1 
ATOM   804  O O    . GLY A  1 112 ? 125.247 125.864 113.244 1.00 62.78  ? 112 GLY U O    1 
ATOM   805  N N    . PHE A  1 113 ? 125.530 128.086 113.016 1.00 58.25  ? 113 PHE U N    1 
ATOM   806  C CA   . PHE A  1 113 ? 124.634 128.150 111.866 1.00 55.82  ? 113 PHE U CA   1 
ATOM   807  C C    . PHE A  1 113 ? 125.158 127.311 110.710 1.00 62.97  ? 113 PHE U C    1 
ATOM   808  O O    . PHE A  1 113 ? 124.394 126.590 110.058 1.00 73.67  ? 113 PHE U O    1 
ATOM   809  C CB   . PHE A  1 113 ? 124.441 129.601 111.430 1.00 56.62  ? 113 PHE U CB   1 
ATOM   810  C CG   . PHE A  1 113 ? 123.471 130.364 112.275 1.00 59.25  ? 113 PHE U CG   1 
ATOM   811  C CD1  . PHE A  1 113 ? 122.276 129.792 112.669 1.00 61.09  ? 113 PHE U CD1  1 
ATOM   812  C CD2  . PHE A  1 113 ? 123.750 131.655 112.682 1.00 63.81  ? 113 PHE U CD2  1 
ATOM   813  C CE1  . PHE A  1 113 ? 121.381 130.492 113.444 1.00 63.15  ? 113 PHE U CE1  1 
ATOM   814  C CE2  . PHE A  1 113 ? 122.859 132.359 113.458 1.00 61.01  ? 113 PHE U CE2  1 
ATOM   815  C CZ   . PHE A  1 113 ? 121.674 131.777 113.839 1.00 61.55  ? 113 PHE U CZ   1 
ATOM   816  N N    . GLY A  1 114 ? 126.458 127.385 110.439 1.00 64.84  ? 114 GLY U N    1 
ATOM   817  C CA   . GLY A  1 114 ? 127.073 126.599 109.394 1.00 68.99  ? 114 GLY U CA   1 
ATOM   818  C C    . GLY A  1 114 ? 127.296 127.324 108.086 1.00 67.95  ? 114 GLY U C    1 
ATOM   819  O O    . GLY A  1 114 ? 127.766 126.701 107.127 1.00 69.49  ? 114 GLY U O    1 
ATOM   820  N N    . MET A  1 115 ? 126.975 128.617 108.011 1.00 69.01  ? 115 MET U N    1 
ATOM   821  C CA   . MET A  1 115 ? 127.233 129.376 106.794 1.00 67.68  ? 115 MET U CA   1 
ATOM   822  C C    . MET A  1 115 ? 128.718 129.635 106.578 1.00 74.08  ? 115 MET U C    1 
ATOM   823  O O    . MET A  1 115 ? 129.130 129.885 105.442 1.00 79.44  ? 115 MET U O    1 
ATOM   824  C CB   . MET A  1 115 ? 126.470 130.701 106.833 1.00 66.69  ? 115 MET U CB   1 
ATOM   825  C CG   . MET A  1 115 ? 127.170 131.795 107.618 1.00 74.23  ? 115 MET U CG   1 
ATOM   826  S SD   . MET A  1 115 ? 127.215 131.451 109.388 1.00 89.34  ? 115 MET U SD   1 
ATOM   827  C CE   . MET A  1 115 ? 128.007 132.930 110.006 1.00 71.68  ? 115 MET U CE   1 
ATOM   828  N N    . THR A  1 116 ? 129.524 129.578 107.637 1.00 66.70  ? 116 THR U N    1 
ATOM   829  C CA   . THR A  1 116 ? 130.966 129.768 107.549 1.00 61.28  ? 116 THR U CA   1 
ATOM   830  C C    . THR A  1 116 ? 131.642 128.662 108.340 1.00 61.81  ? 116 THR U C    1 
ATOM   831  O O    . THR A  1 116 ? 131.346 128.473 109.522 1.00 67.65  ? 116 THR U O    1 
ATOM   832  C CB   . THR A  1 116 ? 131.382 131.139 108.086 1.00 60.55  ? 116 THR U CB   1 
ATOM   833  O OG1  . THR A  1 116 ? 130.643 132.166 107.412 1.00 67.03  ? 116 THR U OG1  1 
ATOM   834  C CG2  . THR A  1 116 ? 132.861 131.369 107.867 1.00 61.65  ? 116 THR U CG2  1 
ATOM   835  N N    . THR A  1 117 ? 132.543 127.930 107.690 1.00 61.76  ? 117 THR U N    1 
ATOM   836  C CA   . THR A  1 117 ? 133.256 126.832 108.324 1.00 56.76  ? 117 THR U CA   1 
ATOM   837  C C    . THR A  1 117 ? 134.729 126.907 107.954 1.00 60.61  ? 117 THR U C    1 
ATOM   838  O O    . THR A  1 117 ? 135.076 127.398 106.874 1.00 67.80  ? 117 THR U O    1 
ATOM   839  C CB   . THR A  1 117 ? 132.695 125.468 107.898 1.00 58.96  ? 117 THR U CB   1 
ATOM   840  O OG1  . THR A  1 117 ? 132.721 125.365 106.471 1.00 73.70  ? 117 THR U OG1  1 
ATOM   841  C CG2  . THR A  1 117 ? 131.267 125.309 108.379 1.00 59.67  ? 117 THR U CG2  1 
ATOM   842  N N    . PRO A  1 118 ? 135.614 126.434 108.827 1.00 59.62  ? 118 PRO U N    1 
ATOM   843  C CA   . PRO A  1 118 ? 137.035 126.375 108.473 1.00 64.57  ? 118 PRO U CA   1 
ATOM   844  C C    . PRO A  1 118 ? 137.279 125.380 107.354 1.00 64.45  ? 118 PRO U C    1 
ATOM   845  O O    . PRO A  1 118 ? 136.555 124.395 107.195 1.00 66.89  ? 118 PRO U O    1 
ATOM   846  C CB   . PRO A  1 118 ? 137.708 125.920 109.777 1.00 63.26  ? 118 PRO U CB   1 
ATOM   847  C CG   . PRO A  1 118 ? 136.716 126.221 110.849 1.00 62.81  ? 118 PRO U CG   1 
ATOM   848  C CD   . PRO A  1 118 ? 135.375 126.030 110.220 1.00 61.25  ? 118 PRO U CD   1 
ATOM   849  N N    . ALA A  1 119 ? 138.323 125.647 106.565 1.00 68.87  ? 119 ALA U N    1 
ATOM   850  C CA   . ALA A  1 119 ? 138.609 124.836 105.394 1.00 73.18  ? 119 ALA U CA   1 
ATOM   851  C C    . ALA A  1 119 ? 140.063 124.409 105.251 1.00 76.69  ? 119 ALA U C    1 
ATOM   852  O O    . ALA A  1 119 ? 140.361 123.611 104.357 1.00 79.59  ? 119 ALA U O    1 
ATOM   853  C CB   . ALA A  1 119 ? 138.190 125.577 104.115 1.00 73.64  ? 119 ALA U CB   1 
ATOM   854  N N    . THR A  1 120 ? 140.973 124.906 106.084 1.00 73.90  ? 120 THR U N    1 
ATOM   855  C CA   . THR A  1 120 ? 142.384 124.565 105.987 1.00 71.39  ? 120 THR U CA   1 
ATOM   856  C C    . THR A  1 120 ? 142.854 123.885 107.263 1.00 76.89  ? 120 THR U C    1 
ATOM   857  O O    . THR A  1 120 ? 142.364 124.173 108.357 1.00 82.99  ? 120 THR U O    1 
ATOM   858  C CB   . THR A  1 120 ? 143.244 125.808 105.734 1.00 69.31  ? 120 THR U CB   1 
ATOM   859  O OG1  . THR A  1 120 ? 143.135 126.699 106.849 1.00 72.52  ? 120 THR U OG1  1 
ATOM   860  C CG2  . THR A  1 120 ? 142.789 126.525 104.477 1.00 74.83  ? 120 THR U CG2  1 
ATOM   861  N N    . VAL A  1 121 ? 143.819 122.977 107.111 1.00 86.57  ? 121 VAL U N    1 
ATOM   862  C CA   . VAL A  1 121 ? 144.447 122.361 108.271 1.00 85.37  ? 121 VAL U CA   1 
ATOM   863  C C    . VAL A  1 121 ? 145.225 123.422 109.033 1.00 87.85  ? 121 VAL U C    1 
ATOM   864  O O    . VAL A  1 121 ? 146.033 124.158 108.456 1.00 92.31  ? 121 VAL U O    1 
ATOM   865  C CB   . VAL A  1 121 ? 145.357 121.202 107.844 1.00 82.52  ? 121 VAL U CB   1 
ATOM   866  C CG1  . VAL A  1 121 ? 146.079 120.626 109.049 1.00 79.95  ? 121 VAL U CG1  1 
ATOM   867  C CG2  . VAL A  1 121 ? 144.549 120.126 107.141 1.00 86.67  ? 121 VAL U CG2  1 
ATOM   868  N N    . GLY A  1 122 ? 144.986 123.503 110.336 1.00 79.45  ? 122 GLY U N    1 
ATOM   869  C CA   . GLY A  1 122 ? 145.531 124.588 111.123 1.00 82.26  ? 122 GLY U CA   1 
ATOM   870  C C    . GLY A  1 122 ? 144.434 125.539 111.542 1.00 81.64  ? 122 GLY U C    1 
ATOM   871  O O    . GLY A  1 122 ? 144.457 126.088 112.647 1.00 92.92  ? 122 GLY U O    1 
ATOM   872  N N    . GLY A  1 123 ? 143.462 125.738 110.657 1.00 64.73  ? 123 GLY U N    1 
ATOM   873  C CA   . GLY A  1 123 ? 142.256 126.449 111.017 1.00 67.15  ? 123 GLY U CA   1 
ATOM   874  C C    . GLY A  1 123 ? 141.236 125.618 111.749 1.00 75.84  ? 123 GLY U C    1 
ATOM   875  O O    . GLY A  1 123 ? 140.228 126.159 112.215 1.00 78.14  ? 123 GLY U O    1 
ATOM   876  N N    . LYS A  1 124 ? 141.470 124.310 111.862 1.00 70.07  ? 124 LYS U N    1 
ATOM   877  C CA   . LYS A  1 124 ? 140.593 123.407 112.596 1.00 67.30  ? 124 LYS U CA   1 
ATOM   878  C C    . LYS A  1 124 ? 141.094 123.104 114.002 1.00 72.81  ? 124 LYS U C    1 
ATOM   879  O O    . LYS A  1 124 ? 140.289 122.987 114.926 1.00 78.35  ? 124 LYS U O    1 
ATOM   880  C CB   . LYS A  1 124 ? 140.423 122.095 111.828 1.00 65.98  ? 124 LYS U CB   1 
ATOM   881  C CG   . LYS A  1 124 ? 139.794 122.257 110.454 1.00 66.40  ? 124 LYS U CG   1 
ATOM   882  C CD   . LYS A  1 124 ? 139.582 120.908 109.785 1.00 68.86  ? 124 LYS U CD   1 
ATOM   883  C CE   . LYS A  1 124 ? 138.925 121.061 108.426 1.00 65.79  ? 124 LYS U CE   1 
ATOM   884  N NZ   . LYS A  1 124 ? 138.750 119.752 107.743 1.00 66.78  ? 124 LYS U NZ   1 
ATOM   885  N N    . ILE A  1 125 ? 142.409 122.973 114.184 1.00 63.57  ? 125 ILE U N    1 
ATOM   886  C CA   . ILE A  1 125 ? 142.959 122.746 115.516 1.00 65.20  ? 125 ILE U CA   1 
ATOM   887  C C    . ILE A  1 125 ? 142.718 123.964 116.403 1.00 69.24  ? 125 ILE U C    1 
ATOM   888  O O    . ILE A  1 125 ? 142.271 123.849 117.557 1.00 77.13  ? 125 ILE U O    1 
ATOM   889  C CB   . ILE A  1 125 ? 144.458 122.414 115.418 1.00 63.27  ? 125 ILE U CB   1 
ATOM   890  C CG1  . ILE A  1 125 ? 144.720 121.521 114.205 1.00 62.85  ? 125 ILE U CG1  1 
ATOM   891  C CG2  . ILE A  1 125 ? 144.940 121.739 116.687 1.00 73.20  ? 125 ILE U CG2  1 
ATOM   892  C CD1  . ILE A  1 125 ? 146.176 121.209 113.985 1.00 59.49  ? 125 ILE U CD1  1 
ATOM   893  N N    . PHE A  1 126 ? 142.997 125.150 115.866 1.00 54.42  ? 126 PHE U N    1 
ATOM   894  C CA   . PHE A  1 126 ? 142.712 126.373 116.598 1.00 58.39  ? 126 PHE U CA   1 
ATOM   895  C C    . PHE A  1 126 ? 141.237 126.469 116.939 1.00 63.99  ? 126 PHE U C    1 
ATOM   896  O O    . PHE A  1 126 ? 140.880 126.963 118.010 1.00 72.50  ? 126 PHE U O    1 
ATOM   897  C CB   . PHE A  1 126 ? 143.163 127.584 115.788 1.00 58.33  ? 126 PHE U CB   1 
ATOM   898  C CG   . PHE A  1 126 ? 143.021 128.888 116.517 1.00 65.60  ? 126 PHE U CG   1 
ATOM   899  C CD1  . PHE A  1 126 ? 143.842 129.188 117.588 1.00 61.34  ? 126 PHE U CD1  1 
ATOM   900  C CD2  . PHE A  1 126 ? 142.075 129.816 116.124 1.00 65.22  ? 126 PHE U CD2  1 
ATOM   901  C CE1  . PHE A  1 126 ? 143.714 130.383 118.258 1.00 59.46  ? 126 PHE U CE1  1 
ATOM   902  C CE2  . PHE A  1 126 ? 141.945 131.012 116.791 1.00 61.58  ? 126 PHE U CE2  1 
ATOM   903  C CZ   . PHE A  1 126 ? 142.765 131.297 117.857 1.00 60.31  ? 126 PHE U CZ   1 
ATOM   904  N N    . LEU A  1 127 ? 140.364 125.976 116.057 1.00 56.21  ? 127 LEU U N    1 
ATOM   905  C CA   . LEU A  1 127 ? 138.943 125.935 116.378 1.00 59.42  ? 127 LEU U CA   1 
ATOM   906  C C    . LEU A  1 127 ? 138.687 125.060 117.597 1.00 60.39  ? 127 LEU U C    1 
ATOM   907  O O    . LEU A  1 127 ? 137.916 125.438 118.489 1.00 69.98  ? 127 LEU U O    1 
ATOM   908  C CB   . LEU A  1 127 ? 138.148 125.426 115.177 1.00 60.54  ? 127 LEU U CB   1 
ATOM   909  C CG   . LEU A  1 127 ? 136.622 125.437 115.295 1.00 63.58  ? 127 LEU U CG   1 
ATOM   910  C CD1  . LEU A  1 127 ? 136.120 124.132 115.877 1.00 62.05  ? 127 LEU U CD1  1 
ATOM   911  C CD2  . LEU A  1 127 ? 136.156 126.608 116.137 1.00 64.18  ? 127 LEU U CD2  1 
ATOM   912  N N    . ILE A  1 128 ? 139.342 123.902 117.667 1.00 58.86  ? 128 ILE U N    1 
ATOM   913  C CA   . ILE A  1 128 ? 139.135 123.002 118.798 1.00 66.31  ? 128 ILE U CA   1 
ATOM   914  C C    . ILE A  1 128 ? 139.525 123.688 120.099 1.00 67.34  ? 128 ILE U C    1 
ATOM   915  O O    . ILE A  1 128 ? 138.741 123.735 121.058 1.00 72.67  ? 128 ILE U O    1 
ATOM   916  C CB   . ILE A  1 128 ? 139.920 121.696 118.592 1.00 64.24  ? 128 ILE U CB   1 
ATOM   917  C CG1  . ILE A  1 128 ? 139.373 120.920 117.395 1.00 60.66  ? 128 ILE U CG1  1 
ATOM   918  C CG2  . ILE A  1 128 ? 139.875 120.846 119.847 1.00 63.83  ? 128 ILE U CG2  1 
ATOM   919  C CD1  . ILE A  1 128 ? 140.110 119.637 117.114 1.00 57.47  ? 128 ILE U CD1  1 
ATOM   920  N N    . PHE A  1 129 ? 140.735 124.256 120.143 1.00 63.27  ? 129 PHE U N    1 
ATOM   921  C CA   . PHE A  1 129 ? 141.184 124.873 121.390 1.00 60.95  ? 129 PHE U CA   1 
ATOM   922  C C    . PHE A  1 129 ? 140.343 126.097 121.749 1.00 64.54  ? 129 PHE U C    1 
ATOM   923  O O    . PHE A  1 129 ? 139.963 126.282 122.915 1.00 67.77  ? 129 PHE U O    1 
ATOM   924  C CB   . PHE A  1 129 ? 142.661 125.242 121.286 1.00 65.38  ? 129 PHE U CB   1 
ATOM   925  C CG   . PHE A  1 129 ? 143.575 124.054 121.210 1.00 70.08  ? 129 PHE U CG   1 
ATOM   926  C CD1  . PHE A  1 129 ? 143.750 123.230 122.306 1.00 71.33  ? 129 PHE U CD1  1 
ATOM   927  C CD2  . PHE A  1 129 ? 144.253 123.758 120.044 1.00 66.76  ? 129 PHE U CD2  1 
ATOM   928  C CE1  . PHE A  1 129 ? 144.588 122.135 122.240 1.00 69.05  ? 129 PHE U CE1  1 
ATOM   929  C CE2  . PHE A  1 129 ? 145.090 122.664 119.974 1.00 66.64  ? 129 PHE U CE2  1 
ATOM   930  C CZ   . PHE A  1 129 ? 145.258 121.851 121.073 1.00 68.87  ? 129 PHE U CZ   1 
ATOM   931  N N    . TYR A  1 130 ? 140.030 126.933 120.757 1.00 61.48  ? 130 TYR U N    1 
ATOM   932  C CA   . TYR A  1 130 ? 139.246 128.136 121.001 1.00 59.24  ? 130 TYR U CA   1 
ATOM   933  C C    . TYR A  1 130 ? 137.875 127.786 121.565 1.00 64.88  ? 130 TYR U C    1 
ATOM   934  O O    . TYR A  1 130 ? 137.435 128.372 122.561 1.00 72.85  ? 130 TYR U O    1 
ATOM   935  C CB   . TYR A  1 130 ? 139.121 128.922 119.696 1.00 54.50  ? 130 TYR U CB   1 
ATOM   936  C CG   . TYR A  1 130 ? 138.628 130.342 119.840 1.00 58.94  ? 130 TYR U CG   1 
ATOM   937  C CD1  . TYR A  1 130 ? 139.490 131.362 120.204 1.00 62.28  ? 130 TYR U CD1  1 
ATOM   938  C CD2  . TYR A  1 130 ? 137.305 130.660 119.584 1.00 59.11  ? 130 TYR U CD2  1 
ATOM   939  C CE1  . TYR A  1 130 ? 139.047 132.655 120.327 1.00 65.39  ? 130 TYR U CE1  1 
ATOM   940  C CE2  . TYR A  1 130 ? 136.854 131.955 119.705 1.00 59.06  ? 130 TYR U CE2  1 
ATOM   941  C CZ   . TYR A  1 130 ? 137.725 132.948 120.077 1.00 63.44  ? 130 TYR U CZ   1 
ATOM   942  O OH   . TYR A  1 130 ? 137.281 134.240 120.200 1.00 75.01  ? 130 TYR U OH   1 
ATOM   943  N N    . GLY A  1 131 ? 137.186 126.824 120.947 1.00 60.10  ? 131 GLY U N    1 
ATOM   944  C CA   . GLY A  1 131 ? 135.882 126.433 121.453 1.00 57.14  ? 131 GLY U CA   1 
ATOM   945  C C    . GLY A  1 131 ? 135.958 125.815 122.833 1.00 61.42  ? 131 GLY U C    1 
ATOM   946  O O    . GLY A  1 131 ? 135.130 126.108 123.704 1.00 72.38  ? 131 GLY U O    1 
ATOM   947  N N    . LEU A  1 132 ? 136.969 124.972 123.065 1.00 56.12  ? 132 LEU U N    1 
ATOM   948  C CA   . LEU A  1 132 ? 137.104 124.332 124.368 1.00 59.71  ? 132 LEU U CA   1 
ATOM   949  C C    . LEU A  1 132 ? 137.271 125.362 125.474 1.00 62.38  ? 132 LEU U C    1 
ATOM   950  O O    . LEU A  1 132 ? 136.727 125.198 126.571 1.00 63.61  ? 132 LEU U O    1 
ATOM   951  C CB   . LEU A  1 132 ? 138.286 123.364 124.353 1.00 55.90  ? 132 LEU U CB   1 
ATOM   952  C CG   . LEU A  1 132 ? 138.633 122.689 125.678 1.00 56.64  ? 132 LEU U CG   1 
ATOM   953  C CD1  . LEU A  1 132 ? 137.472 121.841 126.165 1.00 60.46  ? 132 LEU U CD1  1 
ATOM   954  C CD2  . LEU A  1 132 ? 139.883 121.844 125.531 1.00 60.85  ? 132 LEU U CD2  1 
ATOM   955  N N    . VAL A  1 133 ? 138.019 126.433 125.209 1.00 71.33  ? 133 VAL U N    1 
ATOM   956  C CA   . VAL A  1 133 ? 138.192 127.436 126.258 1.00 63.79  ? 133 VAL U CA   1 
ATOM   957  C C    . VAL A  1 133 ? 137.001 128.392 126.340 1.00 66.45  ? 133 VAL U C    1 
ATOM   958  O O    . VAL A  1 133 ? 136.718 128.929 127.415 1.00 73.44  ? 133 VAL U O    1 
ATOM   959  C CB   . VAL A  1 133 ? 139.508 128.204 126.066 1.00 68.01  ? 133 VAL U CB   1 
ATOM   960  C CG1  . VAL A  1 133 ? 139.711 129.176 127.211 1.00 63.17  ? 133 VAL U CG1  1 
ATOM   961  C CG2  . VAL A  1 133 ? 140.672 127.236 125.989 1.00 68.38  ? 133 VAL U CG2  1 
ATOM   962  N N    . GLY A  1 134 ? 136.294 128.635 125.237 1.00 60.82  ? 134 GLY U N    1 
ATOM   963  C CA   . GLY A  1 134 ? 135.239 129.637 125.240 1.00 53.75  ? 134 GLY U CA   1 
ATOM   964  C C    . GLY A  1 134 ? 133.856 129.185 125.682 1.00 61.44  ? 134 GLY U C    1 
ATOM   965  O O    . GLY A  1 134 ? 133.102 129.966 126.279 1.00 73.07  ? 134 GLY U O    1 
ATOM   966  N N    . CYS A  1 135 ? 133.499 127.933 125.386 1.00 50.88  ? 135 CYS U N    1 
ATOM   967  C CA   . CYS A  1 135 ? 132.160 127.461 125.720 1.00 53.81  ? 135 CYS U CA   1 
ATOM   968  C C    . CYS A  1 135 ? 131.941 127.438 127.228 1.00 67.56  ? 135 CYS U C    1 
ATOM   969  O O    . CYS A  1 135 ? 130.853 127.781 127.715 1.00 73.86  ? 135 CYS U O    1 
ATOM   970  C CB   . CYS A  1 135 ? 131.932 126.078 125.117 1.00 63.25  ? 135 CYS U CB   1 
ATOM   971  S SG   . CYS A  1 135 ? 132.016 126.030 123.312 1.00 73.31  ? 135 CYS U SG   1 
ATOM   972  N N    . SER A  1 136 ? 132.966 127.045 127.990 1.00 57.01  ? 136 SER U N    1 
ATOM   973  C CA   . SER A  1 136 ? 132.850 127.036 129.442 1.00 53.83  ? 136 SER U CA   1 
ATOM   974  C C    . SER A  1 136 ? 132.619 128.439 129.985 1.00 59.66  ? 136 SER U C    1 
ATOM   975  O O    . SER A  1 136 ? 131.785 128.642 130.880 1.00 70.77  ? 136 SER U O    1 
ATOM   976  C CB   . SER A  1 136 ? 134.109 126.428 130.052 1.00 61.46  ? 136 SER U CB   1 
ATOM   977  O OG   . SER A  1 136 ? 134.510 125.275 129.335 1.00 65.42  ? 136 SER U OG   1 
ATOM   978  N N    . SER A  1 137 ? 133.348 129.423 129.458 1.00 48.68  ? 137 SER U N    1 
ATOM   979  C CA   . SER A  1 137 ? 133.163 130.798 129.900 1.00 46.91  ? 137 SER U CA   1 
ATOM   980  C C    . SER A  1 137 ? 131.755 131.288 129.591 1.00 56.79  ? 137 SER U C    1 
ATOM   981  O O    . SER A  1 137 ? 131.132 131.972 130.413 1.00 69.05  ? 137 SER U O    1 
ATOM   982  C CB   . SER A  1 137 ? 134.202 131.703 129.243 1.00 54.69  ? 137 SER U CB   1 
ATOM   983  O OG   . SER A  1 137 ? 135.509 131.199 129.440 1.00 62.60  ? 137 SER U OG   1 
ATOM   984  N N    . THR A  1 138 ? 131.234 130.949 128.412 1.00 56.76  ? 138 THR U N    1 
ATOM   985  C CA   . THR A  1 138 ? 129.875 131.368 128.080 1.00 55.64  ? 138 THR U CA   1 
ATOM   986  C C    . THR A  1 138 ? 128.851 130.736 129.019 1.00 55.79  ? 138 THR U C    1 
ATOM   987  O O    . THR A  1 138 ? 127.896 131.399 129.449 1.00 64.66  ? 138 THR U O    1 
ATOM   988  C CB   . THR A  1 138 ? 129.563 131.028 126.625 1.00 56.33  ? 138 THR U CB   1 
ATOM   989  O OG1  . THR A  1 138 ? 130.568 131.595 125.778 1.00 62.48  ? 138 THR U OG1  1 
ATOM   990  C CG2  . THR A  1 138 ? 128.213 131.588 126.232 1.00 58.03  ? 138 THR U CG2  1 
ATOM   991  N N    . ILE A  1 139 ? 129.030 129.457 129.349 1.00 51.90  ? 139 ILE U N    1 
ATOM   992  C CA   . ILE A  1 139 ? 128.109 128.803 130.281 1.00 55.52  ? 139 ILE U CA   1 
ATOM   993  C C    . ILE A  1 139 ? 128.158 129.474 131.650 1.00 59.90  ? 139 ILE U C    1 
ATOM   994  O O    . ILE A  1 139 ? 127.118 129.710 132.287 1.00 69.53  ? 139 ILE U O    1 
ATOM   995  C CB   . ILE A  1 139 ? 128.427 127.299 130.376 1.00 55.32  ? 139 ILE U CB   1 
ATOM   996  C CG1  . ILE A  1 139 ? 128.111 126.604 129.052 1.00 53.86  ? 139 ILE U CG1  1 
ATOM   997  C CG2  . ILE A  1 139 ? 127.650 126.667 131.515 1.00 58.65  ? 139 ILE U CG2  1 
ATOM   998  C CD1  . ILE A  1 139 ? 128.369 125.118 129.070 1.00 56.87  ? 139 ILE U CD1  1 
ATOM   999  N N    . LEU A  1 140 ? 129.365 129.792 132.123 1.00 57.07  ? 140 LEU U N    1 
ATOM   1000 C CA   . LEU A  1 140 ? 129.494 130.490 133.397 1.00 54.16  ? 140 LEU U CA   1 
ATOM   1001 C C    . LEU A  1 140 ? 128.789 131.839 133.356 1.00 58.01  ? 140 LEU U C    1 
ATOM   1002 O O    . LEU A  1 140 ? 128.125 132.239 134.323 1.00 66.34  ? 140 LEU U O    1 
ATOM   1003 C CB   . LEU A  1 140 ? 130.973 130.663 133.746 1.00 45.70  ? 140 LEU U CB   1 
ATOM   1004 C CG   . LEU A  1 140 ? 131.297 131.435 135.021 1.00 46.62  ? 140 LEU U CG   1 
ATOM   1005 C CD1  . LEU A  1 140 ? 130.701 130.736 136.227 1.00 50.89  ? 140 LEU U CD1  1 
ATOM   1006 C CD2  . LEU A  1 140 ? 132.799 131.588 135.177 1.00 50.14  ? 140 LEU U CD2  1 
ATOM   1007 N N    . PHE A  1 141 ? 128.925 132.557 132.240 1.00 54.57  ? 141 PHE U N    1 
ATOM   1008 C CA   . PHE A  1 141 ? 128.254 133.845 132.100 1.00 51.96  ? 141 PHE U CA   1 
ATOM   1009 C C    . PHE A  1 141 ? 126.741 133.692 132.192 1.00 54.97  ? 141 PHE U C    1 
ATOM   1010 O O    . PHE A  1 141 ? 126.068 134.483 132.862 1.00 70.79  ? 141 PHE U O    1 
ATOM   1011 C CB   . PHE A  1 141 ? 128.652 134.493 130.774 1.00 52.17  ? 141 PHE U CB   1 
ATOM   1012 C CG   . PHE A  1 141 ? 128.079 135.862 130.566 1.00 58.52  ? 141 PHE U CG   1 
ATOM   1013 C CD1  . PHE A  1 141 ? 128.704 136.976 131.095 1.00 58.42  ? 141 PHE U CD1  1 
ATOM   1014 C CD2  . PHE A  1 141 ? 126.920 136.037 129.832 1.00 59.61  ? 141 PHE U CD2  1 
ATOM   1015 C CE1  . PHE A  1 141 ? 128.181 138.235 130.903 1.00 58.57  ? 141 PHE U CE1  1 
ATOM   1016 C CE2  . PHE A  1 141 ? 126.393 137.295 129.637 1.00 57.80  ? 141 PHE U CE2  1 
ATOM   1017 C CZ   . PHE A  1 141 ? 127.024 138.395 130.172 1.00 59.23  ? 141 PHE U CZ   1 
ATOM   1018 N N    . PHE A  1 142 ? 126.189 132.673 131.531 1.00 55.26  ? 142 PHE U N    1 
ATOM   1019 C CA   . PHE A  1 142 ? 124.745 132.463 131.597 1.00 57.19  ? 142 PHE U CA   1 
ATOM   1020 C C    . PHE A  1 142 ? 124.289 132.171 133.024 1.00 59.36  ? 142 PHE U C    1 
ATOM   1021 O O    . PHE A  1 142 ? 123.264 132.701 133.483 1.00 66.88  ? 142 PHE U O    1 
ATOM   1022 C CB   . PHE A  1 142 ? 124.333 131.328 130.658 1.00 56.65  ? 142 PHE U CB   1 
ATOM   1023 C CG   . PHE A  1 142 ? 124.483 131.658 129.202 1.00 61.64  ? 142 PHE U CG   1 
ATOM   1024 C CD1  . PHE A  1 142 ? 124.538 132.972 128.776 1.00 61.51  ? 142 PHE U CD1  1 
ATOM   1025 C CD2  . PHE A  1 142 ? 124.569 130.652 128.257 1.00 61.96  ? 142 PHE U CD2  1 
ATOM   1026 C CE1  . PHE A  1 142 ? 124.676 133.277 127.437 1.00 60.45  ? 142 PHE U CE1  1 
ATOM   1027 C CE2  . PHE A  1 142 ? 124.711 130.951 126.917 1.00 61.02  ? 142 PHE U CE2  1 
ATOM   1028 C CZ   . PHE A  1 142 ? 124.765 132.265 126.507 1.00 57.14  ? 142 PHE U CZ   1 
ATOM   1029 N N    . ASN A  1 143 ? 125.039 131.332 133.744 1.00 59.80  ? 143 ASN U N    1 
ATOM   1030 C CA   . ASN A  1 143 ? 124.662 131.025 135.122 1.00 59.11  ? 143 ASN U CA   1 
ATOM   1031 C C    . ASN A  1 143 ? 124.698 132.269 136.005 1.00 63.69  ? 143 ASN U C    1 
ATOM   1032 O O    . ASN A  1 143 ? 123.789 132.499 136.819 1.00 71.67  ? 143 ASN U O    1 
ATOM   1033 C CB   . ASN A  1 143 ? 125.576 129.937 135.687 1.00 60.66  ? 143 ASN U CB   1 
ATOM   1034 C CG   . ASN A  1 143 ? 125.376 128.600 135.008 1.00 71.29  ? 143 ASN U CG   1 
ATOM   1035 O OD1  . ASN A  1 143 ? 124.690 128.504 133.990 1.00 74.31  ? 143 ASN U OD1  1 
ATOM   1036 N ND2  . ASN A  1 143 ? 125.973 127.556 135.568 1.00 73.45  ? 143 ASN U ND2  1 
ATOM   1037 N N    . LEU A  1 144 ? 125.739 133.090 135.856 1.00 62.19  ? 144 LEU U N    1 
ATOM   1038 C CA   . LEU A  1 144 ? 125.822 134.316 136.646 1.00 60.07  ? 144 LEU U CA   1 
ATOM   1039 C C    . LEU A  1 144 ? 124.669 135.258 136.321 1.00 62.38  ? 144 LEU U C    1 
ATOM   1040 O O    . LEU A  1 144 ? 124.113 135.910 137.214 1.00 65.20  ? 144 LEU U O    1 
ATOM   1041 C CB   . LEU A  1 144 ? 127.163 135.004 136.409 1.00 56.21  ? 144 LEU U CB   1 
ATOM   1042 C CG   . LEU A  1 144 ? 128.403 134.225 136.847 1.00 58.79  ? 144 LEU U CG   1 
ATOM   1043 C CD1  . LEU A  1 144 ? 129.651 135.069 136.682 1.00 61.79  ? 144 LEU U CD1  1 
ATOM   1044 C CD2  . LEU A  1 144 ? 128.263 133.755 138.281 1.00 60.90  ? 144 LEU U CD2  1 
ATOM   1045 N N    . PHE A  1 145 ? 124.290 135.340 135.042 1.00 61.29  ? 145 PHE U N    1 
ATOM   1046 C CA   . PHE A  1 145 ? 123.147 136.170 134.674 1.00 59.39  ? 145 PHE U CA   1 
ATOM   1047 C C    . PHE A  1 145 ? 121.874 135.687 135.353 1.00 62.90  ? 145 PHE U C    1 
ATOM   1048 O O    . PHE A  1 145 ? 121.084 136.494 135.855 1.00 67.53  ? 145 PHE U O    1 
ATOM   1049 C CB   . PHE A  1 145 ? 122.957 136.175 133.158 1.00 56.82  ? 145 PHE U CB   1 
ATOM   1050 C CG   . PHE A  1 145 ? 121.631 136.727 132.723 1.00 61.81  ? 145 PHE U CG   1 
ATOM   1051 C CD1  . PHE A  1 145 ? 121.433 138.090 132.627 1.00 62.81  ? 145 PHE U CD1  1 
ATOM   1052 C CD2  . PHE A  1 145 ? 120.576 135.882 132.434 1.00 65.44  ? 145 PHE U CD2  1 
ATOM   1053 C CE1  . PHE A  1 145 ? 120.211 138.601 132.239 1.00 61.96  ? 145 PHE U CE1  1 
ATOM   1054 C CE2  . PHE A  1 145 ? 119.352 136.386 132.046 1.00 63.96  ? 145 PHE U CE2  1 
ATOM   1055 C CZ   . PHE A  1 145 ? 119.171 137.744 131.947 1.00 61.74  ? 145 PHE U CZ   1 
ATOM   1056 N N    . LEU A  1 146 ? 121.651 134.370 135.373 1.00 66.91  ? 146 LEU U N    1 
ATOM   1057 C CA   . LEU A  1 146 ? 120.449 133.857 136.025 1.00 63.49  ? 146 LEU U CA   1 
ATOM   1058 C C    . LEU A  1 146 ? 120.439 134.201 137.510 1.00 62.38  ? 146 LEU U C    1 
ATOM   1059 O O    . LEU A  1 146 ? 119.402 134.606 138.061 1.00 66.53  ? 146 LEU U O    1 
ATOM   1060 C CB   . LEU A  1 146 ? 120.343 132.347 135.825 1.00 67.39  ? 146 LEU U CB   1 
ATOM   1061 C CG   . LEU A  1 146 ? 119.174 131.665 136.539 1.00 65.23  ? 146 LEU U CG   1 
ATOM   1062 C CD1  . LEU A  1 146 ? 117.863 132.317 136.150 1.00 64.47  ? 146 LEU U CD1  1 
ATOM   1063 C CD2  . LEU A  1 146 ? 119.148 130.183 136.221 1.00 62.60  ? 146 LEU U CD2  1 
ATOM   1064 N N    . GLU A  1 147 ? 121.586 134.051 138.178 1.00 75.11  ? 147 GLU U N    1 
ATOM   1065 C CA   . GLU A  1 147 ? 121.647 134.395 139.597 1.00 71.26  ? 147 GLU U CA   1 
ATOM   1066 C C    . GLU A  1 147 ? 121.329 135.871 139.826 1.00 77.21  ? 147 GLU U C    1 
ATOM   1067 O O    . GLU A  1 147 ? 120.559 136.216 140.737 1.00 81.48  ? 147 GLU U O    1 
ATOM   1068 C CB   . GLU A  1 147 ? 123.022 134.056 140.164 1.00 75.33  ? 147 GLU U CB   1 
ATOM   1069 C CG   . GLU A  1 147 ? 123.237 134.569 141.575 1.00 83.62  ? 147 GLU U CG   1 
ATOM   1070 C CD   . GLU A  1 147 ? 124.648 134.333 142.074 1.00 93.79  ? 147 GLU U CD   1 
ATOM   1071 O OE1  . GLU A  1 147 ? 125.455 133.751 141.319 1.00 93.91  ? 147 GLU U OE1  1 
ATOM   1072 O OE2  . GLU A  1 147 ? 124.951 134.734 143.217 1.00 91.76  ? 147 GLU U OE2  1 
ATOM   1073 N N    . ARG A  1 148 ? 121.904 136.751 139.008 1.00 72.44  ? 148 ARG U N    1 
ATOM   1074 C CA   . ARG A  1 148 ? 121.635 138.179 139.165 1.00 69.79  ? 148 ARG U CA   1 
ATOM   1075 C C    . ARG A  1 148 ? 120.165 138.492 138.940 1.00 71.52  ? 148 ARG U C    1 
ATOM   1076 O O    . ARG A  1 148 ? 119.576 139.313 139.657 1.00 75.15  ? 148 ARG U O    1 
ATOM   1077 C CB   . ARG A  1 148 ? 122.507 138.989 138.202 1.00 68.32  ? 148 ARG U CB   1 
ATOM   1078 C CG   . ARG A  1 148 ? 123.986 138.979 138.532 1.00 68.67  ? 148 ARG U CG   1 
ATOM   1079 C CD   . ARG A  1 148 ? 124.296 139.906 139.688 1.00 69.88  ? 148 ARG U CD   1 
ATOM   1080 N NE   . ARG A  1 148 ? 123.970 139.300 140.973 1.00 72.38  ? 148 ARG U NE   1 
ATOM   1081 C CZ   . ARG A  1 148 ? 124.039 139.930 142.134 1.00 73.15  ? 148 ARG U CZ   1 
ATOM   1082 N NH1  . ARG A  1 148 ? 124.411 141.195 142.215 1.00 76.10  ? 148 ARG U NH1  1 
ATOM   1083 N NH2  . ARG A  1 148 ? 123.727 139.275 143.248 1.00 72.55  ? 148 ARG U NH2  1 
ATOM   1084 N N    . LEU A  1 149 ? 119.550 137.851 137.944 1.00 71.63  ? 149 LEU U N    1 
ATOM   1085 C CA   . LEU A  1 149 ? 118.136 138.092 137.679 1.00 70.49  ? 149 LEU U CA   1 
ATOM   1086 C C    . LEU A  1 149 ? 117.276 137.680 138.865 1.00 68.88  ? 149 LEU U C    1 
ATOM   1087 O O    . LEU A  1 149 ? 116.362 138.413 139.265 1.00 69.42  ? 149 LEU U O    1 
ATOM   1088 C CB   . LEU A  1 149 ? 117.703 137.344 136.420 1.00 69.41  ? 149 LEU U CB   1 
ATOM   1089 C CG   . LEU A  1 149 ? 116.212 137.394 136.085 1.00 65.86  ? 149 LEU U CG   1 
ATOM   1090 C CD1  . LEU A  1 149 ? 115.770 138.817 135.820 1.00 69.42  ? 149 LEU U CD1  1 
ATOM   1091 C CD2  . LEU A  1 149 ? 115.906 136.505 134.895 1.00 69.37  ? 149 LEU U CD2  1 
ATOM   1092 N N    . ILE A  1 150 ? 117.560 136.516 139.453 1.00 73.18  ? 150 ILE U N    1 
ATOM   1093 C CA   . ILE A  1 150 ? 116.778 136.078 140.608 1.00 68.10  ? 150 ILE U CA   1 
ATOM   1094 C C    . ILE A  1 150 ? 116.944 137.059 141.763 1.00 68.70  ? 150 ILE U C    1 
ATOM   1095 O O    . ILE A  1 150 ? 115.963 137.428 142.430 1.00 73.20  ? 150 ILE U O    1 
ATOM   1096 C CB   . ILE A  1 150 ? 117.172 134.649 141.018 1.00 65.28  ? 150 ILE U CB   1 
ATOM   1097 C CG1  . ILE A  1 150 ? 116.857 133.667 139.891 1.00 66.06  ? 150 ILE U CG1  1 
ATOM   1098 C CG2  . ILE A  1 150 ? 116.442 134.245 142.285 1.00 63.38  ? 150 ILE U CG2  1 
ATOM   1099 C CD1  . ILE A  1 150 ? 117.167 132.234 140.237 1.00 70.01  ? 150 ILE U CD1  1 
ATOM   1100 N N    . THR A  1 151 ? 118.174 137.507 142.012 1.00 78.41  ? 151 THR U N    1 
ATOM   1101 C CA   . THR A  1 151 ? 118.400 138.435 143.114 1.00 78.17  ? 151 THR U CA   1 
ATOM   1102 C C    . THR A  1 151 ? 117.641 139.744 142.902 1.00 81.52  ? 151 THR U C    1 
ATOM   1103 O O    . THR A  1 151 ? 117.016 140.267 143.835 1.00 84.28  ? 151 THR U O    1 
ATOM   1104 C CB   . THR A  1 151 ? 119.890 138.708 143.287 1.00 81.33  ? 151 THR U CB   1 
ATOM   1105 O OG1  . THR A  1 151 ? 120.564 137.491 143.612 1.00 84.45  ? 151 THR U OG1  1 
ATOM   1106 C CG2  . THR A  1 151 ? 120.116 139.718 144.397 1.00 80.81  ? 151 THR U CG2  1 
ATOM   1107 N N    . ILE A  1 152 ? 117.683 140.286 141.683 1.00 88.10  ? 152 ILE U N    1 
ATOM   1108 C CA   . ILE A  1 152 ? 117.012 141.559 141.436 1.00 86.56  ? 152 ILE U CA   1 
ATOM   1109 C C    . ILE A  1 152 ? 115.501 141.398 141.520 1.00 85.78  ? 152 ILE U C    1 
ATOM   1110 O O    . ILE A  1 152 ? 114.793 142.300 141.990 1.00 82.69  ? 152 ILE U O    1 
ATOM   1111 C CB   . ILE A  1 152 ? 117.442 142.137 140.074 1.00 84.27  ? 152 ILE U CB   1 
ATOM   1112 C CG1  . ILE A  1 152 ? 116.913 143.560 139.914 1.00 81.53  ? 152 ILE U CG1  1 
ATOM   1113 C CG2  . ILE A  1 152 ? 116.941 141.260 138.943 1.00 84.59  ? 152 ILE U CG2  1 
ATOM   1114 C CD1  . ILE A  1 152 ? 117.796 144.613 140.542 1.00 86.19  ? 152 ILE U CD1  1 
ATOM   1115 N N    . ILE A  1 153 ? 114.973 140.251 141.085 1.00 90.47  ? 153 ILE U N    1 
ATOM   1116 C CA   . ILE A  1 153 ? 113.542 140.002 141.228 1.00 86.09  ? 153 ILE U CA   1 
ATOM   1117 C C    . ILE A  1 153 ? 113.152 140.005 142.700 1.00 86.22  ? 153 ILE U C    1 
ATOM   1118 O O    . ILE A  1 153 ? 112.147 140.612 143.097 1.00 87.48  ? 153 ILE U O    1 
ATOM   1119 C CB   . ILE A  1 153 ? 113.151 138.677 140.551 1.00 81.83  ? 153 ILE U CB   1 
ATOM   1120 C CG1  . ILE A  1 153 ? 113.226 138.806 139.031 1.00 85.07  ? 153 ILE U CG1  1 
ATOM   1121 C CG2  . ILE A  1 153 ? 111.760 138.256 140.980 1.00 78.83  ? 153 ILE U CG2  1 
ATOM   1122 C CD1  . ILE A  1 153 ? 112.884 137.527 138.299 1.00 84.71  ? 153 ILE U CD1  1 
ATOM   1123 N N    . ALA A  1 154 ? 113.947 139.325 143.530 1.00 103.03 ? 154 ALA U N    1 
ATOM   1124 C CA   . ALA A  1 154 ? 113.647 139.293 144.958 1.00 101.17 ? 154 ALA U CA   1 
ATOM   1125 C C    . ALA A  1 154 ? 113.688 140.690 145.564 1.00 102.01 ? 154 ALA U C    1 
ATOM   1126 O O    . ALA A  1 154 ? 112.817 141.057 146.362 1.00 104.27 ? 154 ALA U O    1 
ATOM   1127 C CB   . ALA A  1 154 ? 114.627 138.370 145.681 1.00 100.66 ? 154 ALA U CB   1 
ATOM   1128 N N    . TYR A  1 155 ? 114.694 141.487 145.194 1.00 111.14 ? 155 TYR U N    1 
ATOM   1129 C CA   . TYR A  1 155 ? 114.789 142.839 145.738 1.00 110.99 ? 155 TYR U CA   1 
ATOM   1130 C C    . TYR A  1 155 ? 113.592 143.686 145.323 1.00 112.71 ? 155 TYR U C    1 
ATOM   1131 O O    . TYR A  1 155 ? 113.035 144.431 146.139 1.00 113.35 ? 155 TYR U O    1 
ATOM   1132 C CB   . TYR A  1 155 ? 116.090 143.502 145.292 1.00 111.14 ? 155 TYR U CB   1 
ATOM   1133 C CG   . TYR A  1 155 ? 116.215 144.941 145.740 1.00 114.38 ? 155 TYR U CG   1 
ATOM   1134 C CD1  . TYR A  1 155 ? 116.554 145.254 147.048 1.00 113.51 ? 155 TYR U CD1  1 
ATOM   1135 C CD2  . TYR A  1 155 ? 115.978 145.985 144.855 1.00 116.04 ? 155 TYR U CD2  1 
ATOM   1136 C CE1  . TYR A  1 155 ? 116.668 146.567 147.461 1.00 115.18 ? 155 TYR U CE1  1 
ATOM   1137 C CE2  . TYR A  1 155 ? 116.086 147.301 145.261 1.00 114.99 ? 155 TYR U CE2  1 
ATOM   1138 C CZ   . TYR A  1 155 ? 116.432 147.585 146.564 1.00 115.80 ? 155 TYR U CZ   1 
ATOM   1139 O OH   . TYR A  1 155 ? 116.542 148.894 146.970 1.00 115.06 ? 155 TYR U OH   1 
ATOM   1140 N N    . ILE A  1 156 ? 113.186 143.592 144.055 1.00 112.53 ? 156 ILE U N    1 
ATOM   1141 C CA   . ILE A  1 156 ? 112.042 144.370 143.590 1.00 111.61 ? 156 ILE U CA   1 
ATOM   1142 C C    . ILE A  1 156 ? 110.785 143.961 144.342 1.00 112.75 ? 156 ILE U C    1 
ATOM   1143 O O    . ILE A  1 156 ? 109.985 144.815 144.749 1.00 110.69 ? 156 ILE U O    1 
ATOM   1144 C CB   . ILE A  1 156 ? 111.861 144.213 142.069 1.00 112.85 ? 156 ILE U CB   1 
ATOM   1145 C CG1  . ILE A  1 156 ? 112.870 145.074 141.316 1.00 114.10 ? 156 ILE U CG1  1 
ATOM   1146 C CG2  . ILE A  1 156 ? 110.443 144.577 141.667 1.00 111.54 ? 156 ILE U CG2  1 
ATOM   1147 C CD1  . ILE A  1 156 ? 112.677 145.062 139.818 1.00 112.95 ? 156 ILE U CD1  1 
ATOM   1148 N N    . MET A  1 157 ? 110.577 142.657 144.527 1.00 127.71 ? 157 MET U N    1 
ATOM   1149 C CA   . MET A  1 157 ? 109.384 142.203 145.233 1.00 126.23 ? 157 MET U CA   1 
ATOM   1150 C C    . MET A  1 157 ? 109.380 142.697 146.675 1.00 126.78 ? 157 MET U C    1 
ATOM   1151 O O    . MET A  1 157 ? 108.344 143.156 147.179 1.00 127.92 ? 157 MET U O    1 
ATOM   1152 C CB   . MET A  1 157 ? 109.292 140.680 145.185 1.00 125.38 ? 157 MET U CB   1 
ATOM   1153 C CG   . MET A  1 157 ? 107.873 140.141 145.237 1.00 128.20 ? 157 MET U CG   1 
ATOM   1154 S SD   . MET A  1 157 ? 107.679 138.615 144.299 1.00 136.29 ? 157 MET U SD   1 
ATOM   1155 C CE   . MET A  1 157 ? 106.650 139.172 142.943 1.00 128.22 ? 157 MET U CE   1 
ATOM   1156 N N    . LYS A  1 158 ? 110.526 142.622 147.354 1.00 133.09 ? 158 LYS U N    1 
ATOM   1157 C CA   . LYS A  1 158 ? 110.591 143.102 148.731 1.00 132.28 ? 158 LYS U CA   1 
ATOM   1158 C C    . LYS A  1 158 ? 110.311 144.596 148.812 1.00 134.11 ? 158 LYS U C    1 
ATOM   1159 O O    . LYS A  1 158 ? 109.566 145.050 149.688 1.00 134.89 ? 158 LYS U O    1 
ATOM   1160 C CB   . LYS A  1 158 ? 111.957 142.781 149.338 1.00 132.95 ? 158 LYS U CB   1 
ATOM   1161 C CG   . LYS A  1 158 ? 112.184 143.407 150.704 1.00 134.43 ? 158 LYS U CG   1 
ATOM   1162 C CD   . LYS A  1 158 ? 113.573 143.084 151.232 1.00 135.39 ? 158 LYS U CD   1 
ATOM   1163 C CE   . LYS A  1 158 ? 113.827 143.770 152.562 1.00 133.86 ? 158 LYS U CE   1 
ATOM   1164 N NZ   . LYS A  1 158 ? 112.807 143.393 153.581 1.00 133.56 ? 158 LYS U NZ   1 
ATOM   1165 N N    . SER A  1 159 ? 110.896 145.379 147.902 1.00 141.56 ? 159 SER U N    1 
ATOM   1166 C CA   . SER A  1 159 ? 110.670 146.821 147.924 1.00 142.38 ? 159 SER U CA   1 
ATOM   1167 C C    . SER A  1 159 ? 109.211 147.154 147.642 1.00 142.42 ? 159 SER U C    1 
ATOM   1168 O O    . SER A  1 159 ? 108.632 148.042 148.281 1.00 141.63 ? 159 SER U O    1 
ATOM   1169 C CB   . SER A  1 159 ? 111.583 147.513 146.914 1.00 142.19 ? 159 SER U CB   1 
ATOM   1170 O OG   . SER A  1 159 ? 111.396 148.917 146.939 1.00 143.08 ? 159 SER U OG   1 
ATOM   1171 N N    . CYS A  1 160 ? 108.593 146.450 146.688 1.00 151.47 ? 160 CYS U N    1 
ATOM   1172 C CA   . CYS A  1 160 ? 107.188 146.694 146.388 1.00 152.28 ? 160 CYS U CA   1 
ATOM   1173 C C    . CYS A  1 160 ? 106.304 146.360 147.583 1.00 153.52 ? 160 CYS U C    1 
ATOM   1174 O O    . CYS A  1 160 ? 105.374 147.108 147.902 1.00 153.35 ? 160 CYS U O    1 
ATOM   1175 C CB   . CYS A  1 160 ? 106.765 145.888 145.162 1.00 153.51 ? 160 CYS U CB   1 
ATOM   1176 S SG   . CYS A  1 160 ? 105.037 146.118 144.677 1.00 154.73 ? 160 CYS U SG   1 
ATOM   1177 N N    . HIS A  1 161 ? 106.579 145.239 148.255 1.00 158.96 ? 161 HIS U N    1 
ATOM   1178 C CA   . HIS A  1 161 ? 105.799 144.896 149.439 1.00 158.94 ? 161 HIS U CA   1 
ATOM   1179 C C    . HIS A  1 161 ? 105.968 145.940 150.535 1.00 158.66 ? 161 HIS U C    1 
ATOM   1180 O O    . HIS A  1 161 ? 104.992 146.330 151.188 1.00 157.25 ? 161 HIS U O    1 
ATOM   1181 C CB   . HIS A  1 161 ? 106.194 143.514 149.957 1.00 159.65 ? 161 HIS U CB   1 
ATOM   1182 C CG   . HIS A  1 161 ? 105.440 143.089 151.178 1.00 161.15 ? 161 HIS U CG   1 
ATOM   1183 N ND1  . HIS A  1 161 ? 105.813 143.459 152.451 1.00 160.08 ? 161 HIS U ND1  1 
ATOM   1184 C CD2  . HIS A  1 161 ? 104.331 142.325 151.317 1.00 160.14 ? 161 HIS U CD2  1 
ATOM   1185 C CE1  . HIS A  1 161 ? 104.968 142.942 153.323 1.00 159.08 ? 161 HIS U CE1  1 
ATOM   1186 N NE2  . HIS A  1 161 ? 104.058 142.250 152.661 1.00 159.76 ? 161 HIS U NE2  1 
ATOM   1187 N N    . GLN A  1 162 ? 107.199 146.411 150.743 1.00 162.23 ? 162 GLN U N    1 
ATOM   1188 C CA   . GLN A  1 162 ? 107.429 147.423 151.769 1.00 162.45 ? 162 GLN U CA   1 
ATOM   1189 C C    . GLN A  1 162 ? 106.686 148.712 151.448 1.00 163.70 ? 162 GLN U C    1 
ATOM   1190 O O    . GLN A  1 162 ? 106.075 149.328 152.332 1.00 163.25 ? 162 GLN U O    1 
ATOM   1191 C CB   . GLN A  1 162 ? 108.925 147.686 151.922 1.00 161.77 ? 162 GLN U CB   1 
ATOM   1192 C CG   . GLN A  1 162 ? 109.291 148.512 153.150 1.00 162.01 ? 162 GLN U CG   1 
ATOM   1193 C CD   . GLN A  1 162 ? 109.169 150.005 152.914 1.00 162.97 ? 162 GLN U CD   1 
ATOM   1194 O OE1  . GLN A  1 162 ? 109.129 150.461 151.772 1.00 162.90 ? 162 GLN U OE1  1 
ATOM   1195 N NE2  . GLN A  1 162 ? 109.108 150.773 153.995 1.00 163.41 ? 162 GLN U NE2  1 
ATOM   1196 N N    . ARG A  1 163 ? 106.721 149.141 150.184 1.00 167.06 ? 163 ARG U N    1 
ATOM   1197 C CA   . ARG A  1 163 ? 106.013 150.361 149.805 1.00 166.86 ? 163 ARG U CA   1 
ATOM   1198 C C    . ARG A  1 163 ? 104.506 150.195 149.942 1.00 166.80 ? 163 ARG U C    1 
ATOM   1199 O O    . ARG A  1 163 ? 103.813 151.113 150.391 1.00 165.32 ? 163 ARG U O    1 
ATOM   1200 C CB   . ARG A  1 163 ? 106.382 150.768 148.380 1.00 166.31 ? 163 ARG U CB   1 
ATOM   1201 C CG   . ARG A  1 163 ? 105.678 152.033 147.903 1.00 166.14 ? 163 ARG U CG   1 
ATOM   1202 C CD   . ARG A  1 163 ? 106.204 152.495 146.553 1.00 167.11 ? 163 ARG U CD   1 
ATOM   1203 N NE   . ARG A  1 163 ? 107.524 153.105 146.655 1.00 167.73 ? 163 ARG U NE   1 
ATOM   1204 C CZ   . ARG A  1 163 ? 108.665 152.477 146.406 1.00 167.39 ? 163 ARG U CZ   1 
ATOM   1205 N NH1  . ARG A  1 163 ? 108.684 151.208 146.036 1.00 167.38 ? 163 ARG U NH1  1 
ATOM   1206 N NH2  . ARG A  1 163 ? 109.812 153.138 146.535 1.00 165.94 ? 163 ARG U NH2  1 
ATOM   1207 N N    . GLN A  1 164 ? 103.977 149.026 149.563 1.00 168.40 ? 164 GLN U N    1 
ATOM   1208 C CA   . GLN A  1 164 ? 102.545 148.791 149.707 1.00 168.38 ? 164 GLN U CA   1 
ATOM   1209 C C    . GLN A  1 164 ? 102.128 148.732 151.171 1.00 168.78 ? 164 GLN U C    1 
ATOM   1210 O O    . GLN A  1 164 ? 100.992 149.081 151.503 1.00 167.95 ? 164 GLN U O    1 
ATOM   1211 C CB   . GLN A  1 164 ? 102.150 147.499 148.991 1.00 167.72 ? 164 GLN U CB   1 
ATOM   1212 C CG   . GLN A  1 164 ? 100.663 147.183 149.066 1.00 167.72 ? 164 GLN U CG   1 
ATOM   1213 C CD   . GLN A  1 164 ? 99.813  148.213 148.349 1.00 167.22 ? 164 GLN U CD   1 
ATOM   1214 O OE1  . GLN A  1 164 ? 100.279 148.899 147.441 1.00 167.44 ? 164 GLN U OE1  1 
ATOM   1215 N NE2  . GLN A  1 164 ? 98.555  148.326 148.757 1.00 166.28 ? 164 GLN U NE2  1 
ATOM   1216 N N    . LEU A  1 165 ? 103.029 148.295 152.054 1.00 168.85 ? 165 LEU U N    1 
ATOM   1217 C CA   . LEU A  1 165 ? 102.693 148.242 153.474 1.00 168.08 ? 165 LEU U CA   1 
ATOM   1218 C C    . LEU A  1 165 ? 102.399 149.630 154.025 1.00 167.76 ? 165 LEU U C    1 
ATOM   1219 O O    . LEU A  1 165 ? 101.443 149.817 154.788 1.00 166.88 ? 165 LEU U O    1 
ATOM   1220 C CB   . LEU A  1 165 ? 103.826 147.582 154.257 1.00 166.92 ? 165 LEU U CB   1 
ATOM   1221 C CG   . LEU A  1 165 ? 103.531 147.242 155.719 1.00 166.50 ? 165 LEU U CG   1 
ATOM   1222 C CD1  . LEU A  1 165 ? 103.849 148.425 156.619 1.00 165.66 ? 165 LEU U CD1  1 
ATOM   1223 C CD2  . LEU A  1 165 ? 102.083 146.811 155.887 1.00 166.47 ? 165 LEU U CD2  1 
ATOM   1224 N N    . ARG A  1 166 ? 103.206 150.620 153.647 1.00 169.74 ? 166 ARG U N    1 
ATOM   1225 C CA   . ARG A  1 166 ? 103.022 151.995 154.117 1.00 169.51 ? 166 ARG U CA   1 
ATOM   1226 C C    . ARG A  1 166 ? 102.074 152.733 153.172 1.00 169.86 ? 166 ARG U C    1 
ATOM   1227 O O    . ARG A  1 166 ? 102.461 153.596 152.382 1.00 169.25 ? 166 ARG U O    1 
ATOM   1228 C CB   . ARG A  1 166 ? 104.369 152.699 154.236 1.00 168.94 ? 166 ARG U CB   1 
ATOM   1229 C CG   . ARG A  1 166 ? 104.302 154.063 154.900 1.00 167.85 ? 166 ARG U CG   1 
ATOM   1230 C CD   . ARG A  1 166 ? 105.690 154.649 155.096 1.00 167.97 ? 166 ARG U CD   1 
ATOM   1231 N NE   . ARG A  1 166 ? 106.431 154.723 153.843 1.00 168.60 ? 166 ARG U NE   1 
ATOM   1232 C CZ   . ARG A  1 166 ? 106.393 155.753 153.011 1.00 168.69 ? 166 ARG U CZ   1 
ATOM   1233 N NH1  . ARG A  1 166 ? 105.654 156.819 153.262 1.00 167.88 ? 166 ARG U NH1  1 
ATOM   1234 N NH2  . ARG A  1 166 ? 107.118 155.715 151.894 1.00 168.58 ? 166 ARG U NH2  1 
ATOM   1235 N N    . ARG A  1 167 ? 100.797 152.375 153.279 1.00 172.69 ? 167 ARG U N    1 
ATOM   1236 C CA   . ARG A  1 167 ? 99.762  152.965 152.438 1.00 172.08 ? 167 ARG U CA   1 
ATOM   1237 C C    . ARG A  1 167 ? 98.665  153.601 153.287 1.00 171.20 ? 167 ARG U C    1 
ATOM   1238 O O    . ARG A  1 167 ? 97.914  152.904 153.971 1.00 171.37 ? 167 ARG U O    1 
ATOM   1239 C CB   . ARG A  1 167 ? 99.159  151.904 151.511 1.00 171.27 ? 167 ARG U CB   1 
ATOM   1240 C CG   . ARG A  1 167 ? 97.937  152.370 150.736 1.00 170.76 ? 167 ARG U CG   1 
ATOM   1241 C CD   . ARG A  1 167 ? 98.278  153.479 149.755 1.00 170.24 ? 167 ARG U CD   1 
ATOM   1242 N NE   . ARG A  1 167 ? 99.181  153.022 148.705 1.00 170.87 ? 167 ARG U NE   1 
ATOM   1243 C CZ   . ARG A  1 167 ? 99.557  153.760 147.670 1.00 171.44 ? 167 ARG U CZ   1 
ATOM   1244 N NH1  . ARG A  1 167 ? 99.127  154.999 147.509 1.00 170.58 ? 167 ARG U NH1  1 
ATOM   1245 N NH2  . ARG A  1 167 ? 100.385 153.238 146.769 1.00 171.97 ? 167 ARG U NH2  1 
ATOM   1246 N N    . ALA A  1 188 ? 116.786 139.047 150.819 1.00 134.57 ? 188 ALA U N    1 
ATOM   1247 C CA   . ALA A  1 188 ? 117.133 138.121 151.890 1.00 136.57 ? 188 ALA U CA   1 
ATOM   1248 C C    . ALA A  1 188 ? 116.214 136.902 151.880 1.00 137.44 ? 188 ALA U C    1 
ATOM   1249 O O    . ALA A  1 188 ? 116.456 135.935 151.158 1.00 135.92 ? 188 ALA U O    1 
ATOM   1250 C CB   . ALA A  1 188 ? 117.069 138.822 153.237 1.00 134.43 ? 188 ALA U CB   1 
ATOM   1251 N N    . GLY A  1 189 ? 115.158 136.957 152.688 1.00 136.59 ? 189 GLY U N    1 
ATOM   1252 C CA   . GLY A  1 189 ? 114.216 135.859 152.779 1.00 134.68 ? 189 GLY U CA   1 
ATOM   1253 C C    . GLY A  1 189 ? 112.989 136.050 151.910 1.00 133.41 ? 189 GLY U C    1 
ATOM   1254 O O    . GLY A  1 189 ? 111.953 135.418 152.135 1.00 133.83 ? 189 GLY U O    1 
ATOM   1255 N N    . TRP A  1 190 ? 113.093 136.929 150.912 1.00 133.05 ? 190 TRP U N    1 
ATOM   1256 C CA   . TRP A  1 190 ? 111.984 137.257 150.028 1.00 134.78 ? 190 TRP U CA   1 
ATOM   1257 C C    . TRP A  1 190 ? 112.132 136.622 148.648 1.00 134.58 ? 190 TRP U C    1 
ATOM   1258 O O    . TRP A  1 190 ? 111.521 137.094 147.687 1.00 136.14 ? 190 TRP U O    1 
ATOM   1259 C CB   . TRP A  1 190 ? 111.843 138.774 149.894 1.00 135.10 ? 190 TRP U CB   1 
ATOM   1260 C CG   . TRP A  1 190 ? 111.597 139.480 151.191 1.00 136.28 ? 190 TRP U CG   1 
ATOM   1261 C CD1  . TRP A  1 190 ? 112.509 139.740 152.170 1.00 137.03 ? 190 TRP U CD1  1 
ATOM   1262 C CD2  . TRP A  1 190 ? 110.354 140.036 151.644 1.00 137.08 ? 190 TRP U CD2  1 
ATOM   1263 N NE1  . TRP A  1 190 ? 111.912 140.414 153.208 1.00 137.04 ? 190 TRP U NE1  1 
ATOM   1264 C CE2  . TRP A  1 190 ? 110.590 140.608 152.909 1.00 137.45 ? 190 TRP U CE2  1 
ATOM   1265 C CE3  . TRP A  1 190 ? 109.069 140.098 151.104 1.00 135.85 ? 190 TRP U CE3  1 
ATOM   1266 C CZ2  . TRP A  1 190 ? 109.587 141.235 153.641 1.00 136.44 ? 190 TRP U CZ2  1 
ATOM   1267 C CZ3  . TRP A  1 190 ? 108.074 140.722 151.833 1.00 136.11 ? 190 TRP U CZ3  1 
ATOM   1268 C CH2  . TRP A  1 190 ? 108.339 141.283 153.089 1.00 136.36 ? 190 TRP U CH2  1 
ATOM   1269 N N    . LYS A  1 191 ? 112.924 135.565 148.533 1.00 119.46 ? 191 LYS U N    1 
ATOM   1270 C CA   . LYS A  1 191 ? 113.163 134.961 147.227 1.00 119.99 ? 191 LYS U CA   1 
ATOM   1271 C C    . LYS A  1 191 ? 111.874 134.362 146.679 1.00 121.09 ? 191 LYS U C    1 
ATOM   1272 O O    . LYS A  1 191 ? 111.176 133.642 147.400 1.00 122.38 ? 191 LYS U O    1 
ATOM   1273 C CB   . LYS A  1 191 ? 114.244 133.890 147.327 1.00 121.14 ? 191 LYS U CB   1 
ATOM   1274 C CG   . LYS A  1 191 ? 115.623 134.438 147.649 1.00 122.78 ? 191 LYS U CG   1 
ATOM   1275 C CD   . LYS A  1 191 ? 116.676 133.341 147.633 1.00 122.52 ? 191 LYS U CD   1 
ATOM   1276 C CE   . LYS A  1 191 ? 118.056 133.898 147.940 1.00 122.69 ? 191 LYS U CE   1 
ATOM   1277 N NZ   . LYS A  1 191 ? 119.092 132.829 147.951 1.00 122.44 ? 191 LYS U NZ   1 
ATOM   1278 N N    . PRO A  1 192 ? 111.527 134.627 145.422 1.00 110.52 ? 192 PRO U N    1 
ATOM   1279 C CA   . PRO A  1 192 ? 110.282 134.092 144.868 1.00 110.10 ? 192 PRO U CA   1 
ATOM   1280 C C    . PRO A  1 192 ? 110.393 132.607 144.561 1.00 110.24 ? 192 PRO U C    1 
ATOM   1281 O O    . PRO A  1 192 ? 111.480 132.035 144.483 1.00 110.65 ? 192 PRO U O    1 
ATOM   1282 C CB   . PRO A  1 192 ? 110.092 134.908 143.588 1.00 107.87 ? 192 PRO U CB   1 
ATOM   1283 C CG   . PRO A  1 192 ? 111.479 135.251 143.172 1.00 107.52 ? 192 PRO U CG   1 
ATOM   1284 C CD   . PRO A  1 192 ? 112.256 135.455 144.446 1.00 108.34 ? 192 PRO U CD   1 
ATOM   1285 N N    . SER A  1 193 ? 109.230 131.982 144.386 1.00 105.82 ? 193 SER U N    1 
ATOM   1286 C CA   . SER A  1 193 ? 109.171 130.565 144.066 1.00 102.51 ? 193 SER U CA   1 
ATOM   1287 C C    . SER A  1 193 ? 109.479 130.339 142.585 1.00 105.12 ? 193 SER U C    1 
ATOM   1288 O O    . SER A  1 193 ? 109.652 131.280 141.805 1.00 109.98 ? 193 SER U O    1 
ATOM   1289 C CB   . SER A  1 193 ? 107.805 129.996 144.435 1.00 101.56 ? 193 SER U CB   1 
ATOM   1290 O OG   . SER A  1 193 ? 106.771 130.626 143.697 1.00 104.19 ? 193 SER U OG   1 
ATOM   1291 N N    . VAL A  1 194 ? 109.545 129.066 142.194 1.00 88.57  ? 194 VAL U N    1 
ATOM   1292 C CA   . VAL A  1 194 ? 109.925 128.719 140.828 1.00 89.03  ? 194 VAL U CA   1 
ATOM   1293 C C    . VAL A  1 194 ? 108.847 129.145 139.837 1.00 95.63  ? 194 VAL U C    1 
ATOM   1294 O O    . VAL A  1 194 ? 109.148 129.558 138.710 1.00 101.41 ? 194 VAL U O    1 
ATOM   1295 C CB   . VAL A  1 194 ? 110.224 127.213 140.728 1.00 89.75  ? 194 VAL U CB   1 
ATOM   1296 C CG1  . VAL A  1 194 ? 110.643 126.856 139.317 1.00 92.40  ? 194 VAL U CG1  1 
ATOM   1297 C CG2  . VAL A  1 194 ? 111.303 126.828 141.722 1.00 92.32  ? 194 VAL U CG2  1 
ATOM   1298 N N    . TYR A  1 195 ? 107.577 129.037 140.232 1.00 100.28 ? 195 TYR U N    1 
ATOM   1299 C CA   . TYR A  1 195 ? 106.483 129.314 139.306 1.00 103.86 ? 195 TYR U CA   1 
ATOM   1300 C C    . TYR A  1 195 ? 106.522 130.756 138.809 1.00 106.81 ? 195 TYR U C    1 
ATOM   1301 O O    . TYR A  1 195 ? 106.364 131.017 137.608 1.00 109.28 ? 195 TYR U O    1 
ATOM   1302 C CB   . TYR A  1 195 ? 105.153 129.007 139.995 1.00 102.50 ? 195 TYR U CB   1 
ATOM   1303 C CG   . TYR A  1 195 ? 103.995 128.758 139.057 1.00 107.63 ? 195 TYR U CG   1 
ATOM   1304 C CD1  . TYR A  1 195 ? 103.981 127.655 138.218 1.00 107.97 ? 195 TYR U CD1  1 
ATOM   1305 C CD2  . TYR A  1 195 ? 102.904 129.618 139.032 1.00 106.89 ? 195 TYR U CD2  1 
ATOM   1306 C CE1  . TYR A  1 195 ? 102.919 127.421 137.366 1.00 110.04 ? 195 TYR U CE1  1 
ATOM   1307 C CE2  . TYR A  1 195 ? 101.838 129.391 138.183 1.00 104.31 ? 195 TYR U CE2  1 
ATOM   1308 C CZ   . TYR A  1 195 ? 101.852 128.291 137.353 1.00 109.58 ? 195 TYR U CZ   1 
ATOM   1309 O OH   . TYR A  1 195 ? 100.795 128.059 136.506 1.00 110.96 ? 195 TYR U OH   1 
ATOM   1310 N N    . TYR A  1 196 ? 106.742 131.710 139.715 1.00 94.80  ? 196 TYR U N    1 
ATOM   1311 C CA   . TYR A  1 196 ? 106.776 133.108 139.304 1.00 94.32  ? 196 TYR U CA   1 
ATOM   1312 C C    . TYR A  1 196 ? 107.978 133.398 138.418 1.00 98.16  ? 196 TYR U C    1 
ATOM   1313 O O    . TYR A  1 196 ? 107.878 134.176 137.461 1.00 103.62 ? 196 TYR U O    1 
ATOM   1314 C CB   . TYR A  1 196 ? 106.780 134.018 140.532 1.00 98.37  ? 196 TYR U CB   1 
ATOM   1315 C CG   . TYR A  1 196 ? 105.449 134.076 141.245 1.00 103.60 ? 196 TYR U CG   1 
ATOM   1316 C CD1  . TYR A  1 196 ? 104.328 133.452 140.714 1.00 99.75  ? 196 TYR U CD1  1 
ATOM   1317 C CD2  . TYR A  1 196 ? 105.311 134.760 142.444 1.00 103.45 ? 196 TYR U CD2  1 
ATOM   1318 C CE1  . TYR A  1 196 ? 103.110 133.503 141.359 1.00 99.23  ? 196 TYR U CE1  1 
ATOM   1319 C CE2  . TYR A  1 196 ? 104.095 134.812 143.099 1.00 101.26 ? 196 TYR U CE2  1 
ATOM   1320 C CZ   . TYR A  1 196 ? 102.999 134.185 142.551 1.00 101.95 ? 196 TYR U CZ   1 
ATOM   1321 O OH   . TYR A  1 196 ? 101.787 134.236 143.196 1.00 105.49 ? 196 TYR U OH   1 
ATOM   1322 N N    . VAL A  1 197 ? 109.122 132.782 138.714 1.00 82.06  ? 197 VAL U N    1 
ATOM   1323 C CA   . VAL A  1 197 ? 110.292 132.955 137.857 1.00 79.91  ? 197 VAL U CA   1 
ATOM   1324 C C    . VAL A  1 197 ? 110.006 132.429 136.458 1.00 83.41  ? 197 VAL U C    1 
ATOM   1325 O O    . VAL A  1 197 ? 110.373 133.058 135.454 1.00 88.66  ? 197 VAL U O    1 
ATOM   1326 C CB   . VAL A  1 197 ? 111.520 132.266 138.480 1.00 77.18  ? 197 VAL U CB   1 
ATOM   1327 C CG1  . VAL A  1 197 ? 112.724 132.415 137.570 1.00 81.02  ? 197 VAL U CG1  1 
ATOM   1328 C CG2  . VAL A  1 197 ? 111.814 132.849 139.848 1.00 82.74  ? 197 VAL U CG2  1 
ATOM   1329 N N    . MET A  1 198 ? 109.351 131.275 136.366 1.00 81.13  ? 198 MET U N    1 
ATOM   1330 C CA   . MET A  1 198 ? 109.007 130.724 135.059 1.00 82.15  ? 198 MET U CA   1 
ATOM   1331 C C    . MET A  1 198 ? 108.070 131.653 134.297 1.00 85.32  ? 198 MET U C    1 
ATOM   1332 O O    . MET A  1 198 ? 108.258 131.888 133.097 1.00 91.09  ? 198 MET U O    1 
ATOM   1333 C CB   . MET A  1 198 ? 108.379 129.341 135.223 1.00 84.01  ? 198 MET U CB   1 
ATOM   1334 C CG   . MET A  1 198 ? 108.163 128.600 133.918 1.00 85.78  ? 198 MET U CG   1 
ATOM   1335 S SD   . MET A  1 198 ? 107.490 126.947 134.167 1.00 97.56  ? 198 MET U SD   1 
ATOM   1336 C CE   . MET A  1 198 ? 105.736 127.304 134.224 1.00 88.07  ? 198 MET U CE   1 
ATOM   1337 N N    . LEU A  1 199 ? 107.055 132.194 134.975 1.00 82.93  ? 199 LEU U N    1 
ATOM   1338 C CA   . LEU A  1 199 ? 106.133 133.101 134.295 1.00 82.75  ? 199 LEU U CA   1 
ATOM   1339 C C    . LEU A  1 199 ? 106.845 134.360 133.811 1.00 86.73  ? 199 LEU U C    1 
ATOM   1340 O O    . LEU A  1 199 ? 106.618 134.818 132.683 1.00 90.08  ? 199 LEU U O    1 
ATOM   1341 C CB   . LEU A  1 199 ? 104.972 133.464 135.217 1.00 79.36  ? 199 LEU U CB   1 
ATOM   1342 C CG   . LEU A  1 199 ? 104.035 132.318 135.603 1.00 86.97  ? 199 LEU U CG   1 
ATOM   1343 C CD1  . LEU A  1 199 ? 102.820 132.851 136.338 1.00 86.81  ? 199 LEU U CD1  1 
ATOM   1344 C CD2  . LEU A  1 199 ? 103.619 131.535 134.371 1.00 86.55  ? 199 LEU U CD2  1 
ATOM   1345 N N    . ILE A  1 200 ? 107.716 134.928 134.646 1.00 79.30  ? 200 ILE U N    1 
ATOM   1346 C CA   . ILE A  1 200 ? 108.446 136.129 134.253 1.00 73.92  ? 200 ILE U CA   1 
ATOM   1347 C C    . ILE A  1 200 ? 109.337 135.845 133.053 1.00 74.89  ? 200 ILE U C    1 
ATOM   1348 O O    . ILE A  1 200 ? 109.403 136.642 132.108 1.00 80.52  ? 200 ILE U O    1 
ATOM   1349 C CB   . ILE A  1 200 ? 109.251 136.677 135.443 1.00 71.53  ? 200 ILE U CB   1 
ATOM   1350 C CG1  . ILE A  1 200 ? 108.314 137.281 136.488 1.00 75.99  ? 200 ILE U CG1  1 
ATOM   1351 C CG2  . ILE A  1 200 ? 110.268 137.697 134.970 1.00 71.59  ? 200 ILE U CG2  1 
ATOM   1352 C CD1  . ILE A  1 200 ? 109.021 137.827 137.700 1.00 74.59  ? 200 ILE U CD1  1 
ATOM   1353 N N    . LEU A  1 201 ? 110.041 134.710 133.071 1.00 68.01  ? 201 LEU U N    1 
ATOM   1354 C CA   . LEU A  1 201 ? 110.908 134.369 131.950 1.00 69.62  ? 201 LEU U CA   1 
ATOM   1355 C C    . LEU A  1 201 ? 110.106 134.171 130.671 1.00 76.02  ? 201 LEU U C    1 
ATOM   1356 O O    . LEU A  1 201 ? 110.530 134.608 129.593 1.00 78.55  ? 201 LEU U O    1 
ATOM   1357 C CB   . LEU A  1 201 ? 111.727 133.125 132.276 1.00 69.31  ? 201 LEU U CB   1 
ATOM   1358 C CG   . LEU A  1 201 ? 112.946 133.350 133.167 1.00 66.43  ? 201 LEU U CG   1 
ATOM   1359 C CD1  . LEU A  1 201 ? 113.611 132.032 133.503 1.00 68.63  ? 201 LEU U CD1  1 
ATOM   1360 C CD2  . LEU A  1 201 ? 113.928 134.280 132.485 1.00 64.92  ? 201 LEU U CD2  1 
ATOM   1361 N N    . CYS A  1 202 ? 108.952 133.511 130.761 1.00 84.64  ? 202 CYS U N    1 
ATOM   1362 C CA   . CYS A  1 202 ? 108.131 133.320 129.571 1.00 80.07  ? 202 CYS U CA   1 
ATOM   1363 C C    . CYS A  1 202 ? 107.665 134.657 129.003 1.00 81.77  ? 202 CYS U C    1 
ATOM   1364 O O    . CYS A  1 202 ? 107.730 134.882 127.787 1.00 85.44  ? 202 CYS U O    1 
ATOM   1365 C CB   . CYS A  1 202 ? 106.931 132.429 129.889 1.00 77.82  ? 202 CYS U CB   1 
ATOM   1366 S SG   . CYS A  1 202 ? 107.351 130.704 130.225 1.00 95.53  ? 202 CYS U SG   1 
ATOM   1367 N N    . THR A  1 203 ? 107.202 135.559 129.870 1.00 71.56  ? 203 THR U N    1 
ATOM   1368 C CA   . THR A  1 203 ? 106.760 136.867 129.391 1.00 71.38  ? 203 THR U CA   1 
ATOM   1369 C C    . THR A  1 203 ? 107.906 137.625 128.732 1.00 74.30  ? 203 THR U C    1 
ATOM   1370 O O    . THR A  1 203 ? 107.736 138.212 127.654 1.00 79.46  ? 203 THR U O    1 
ATOM   1371 C CB   . THR A  1 203 ? 106.177 137.679 130.544 1.00 75.71  ? 203 THR U CB   1 
ATOM   1372 O OG1  . THR A  1 203 ? 105.005 137.021 131.047 1.00 80.82  ? 203 THR U OG1  1 
ATOM   1373 C CG2  . THR A  1 203 ? 105.800 139.071 130.075 1.00 79.18  ? 203 THR U CG2  1 
ATOM   1374 N N    . ALA A  1 204 ? 109.084 137.620 129.361 1.00 73.85  ? 204 ALA U N    1 
ATOM   1375 C CA   . ALA A  1 204 ? 110.221 138.335 128.793 1.00 74.14  ? 204 ALA U CA   1 
ATOM   1376 C C    . ALA A  1 204 ? 110.625 137.750 127.447 1.00 77.40  ? 204 ALA U C    1 
ATOM   1377 O O    . ALA A  1 204 ? 110.931 138.493 126.507 1.00 79.88  ? 204 ALA U O    1 
ATOM   1378 C CB   . ALA A  1 204 ? 111.398 138.311 129.764 1.00 74.01  ? 204 ALA U CB   1 
ATOM   1379 N N    . SER A  1 205 ? 110.632 136.421 127.334 1.00 78.39  ? 205 SER U N    1 
ATOM   1380 C CA   . SER A  1 205 ? 111.017 135.796 126.073 1.00 75.58  ? 205 SER U CA   1 
ATOM   1381 C C    . SER A  1 205 ? 110.025 136.121 124.968 1.00 72.59  ? 205 SER U C    1 
ATOM   1382 O O    . SER A  1 205 ? 110.423 136.408 123.834 1.00 69.85  ? 205 SER U O    1 
ATOM   1383 C CB   . SER A  1 205 ? 111.145 134.285 126.257 1.00 71.83  ? 205 SER U CB   1 
ATOM   1384 O OG   . SER A  1 205 ? 111.646 133.674 125.082 1.00 80.85  ? 205 SER U OG   1 
ATOM   1385 N N    . ILE A  1 206 ? 108.725 136.095 125.277 1.00 75.35  ? 206 ILE U N    1 
ATOM   1386 C CA   . ILE A  1 206 ? 107.729 136.436 124.266 1.00 75.76  ? 206 ILE U CA   1 
ATOM   1387 C C    . ILE A  1 206 ? 107.897 137.884 123.820 1.00 75.70  ? 206 ILE U C    1 
ATOM   1388 O O    . ILE A  1 206 ? 107.847 138.190 122.621 1.00 79.92  ? 206 ILE U O    1 
ATOM   1389 C CB   . ILE A  1 206 ? 106.310 136.171 124.797 1.00 77.01  ? 206 ILE U CB   1 
ATOM   1390 C CG1  . ILE A  1 206 ? 106.065 134.670 124.942 1.00 76.71  ? 206 ILE U CG1  1 
ATOM   1391 C CG2  . ILE A  1 206 ? 105.273 136.792 123.880 1.00 75.96  ? 206 ILE U CG2  1 
ATOM   1392 C CD1  . ILE A  1 206 ? 104.692 134.326 125.469 1.00 77.79  ? 206 ILE U CD1  1 
ATOM   1393 N N    . LEU A  1 207 ? 108.098 138.798 124.773 1.00 72.29  ? 207 LEU U N    1 
ATOM   1394 C CA   . LEU A  1 207 ? 108.262 140.201 124.408 1.00 69.26  ? 207 LEU U CA   1 
ATOM   1395 C C    . LEU A  1 207 ? 109.505 140.410 123.548 1.00 70.83  ? 207 LEU U C    1 
ATOM   1396 O O    . LEU A  1 207 ? 109.466 141.152 122.558 1.00 76.27  ? 207 LEU U O    1 
ATOM   1397 C CB   . LEU A  1 207 ? 108.330 141.066 125.665 1.00 74.49  ? 207 LEU U CB   1 
ATOM   1398 C CG   . LEU A  1 207 ? 107.092 141.912 125.965 1.00 77.75  ? 207 LEU U CG   1 
ATOM   1399 C CD1  . LEU A  1 207 ? 105.951 141.041 126.460 1.00 77.74  ? 207 LEU U CD1  1 
ATOM   1400 C CD2  . LEU A  1 207 ? 107.421 142.992 126.981 1.00 76.48  ? 207 LEU U CD2  1 
ATOM   1401 N N    . ILE A  1 208 ? 110.613 139.760 123.907 1.00 67.55  ? 208 ILE U N    1 
ATOM   1402 C CA   . ILE A  1 208 ? 111.841 139.914 123.132 1.00 69.28  ? 208 ILE U CA   1 
ATOM   1403 C C    . ILE A  1 208 ? 111.661 139.364 121.725 1.00 74.83  ? 208 ILE U C    1 
ATOM   1404 O O    . ILE A  1 208 ? 112.099 139.970 120.743 1.00 72.01  ? 208 ILE U O    1 
ATOM   1405 C CB   . ILE A  1 208 ? 113.021 139.242 123.855 1.00 68.76  ? 208 ILE U CB   1 
ATOM   1406 C CG1  . ILE A  1 208 ? 113.593 140.178 124.919 1.00 73.36  ? 208 ILE U CG1  1 
ATOM   1407 C CG2  . ILE A  1 208 ? 114.098 138.860 122.861 1.00 66.33  ? 208 ILE U CG2  1 
ATOM   1408 C CD1  . ILE A  1 208 ? 114.359 139.465 126.007 1.00 72.63  ? 208 ILE U CD1  1 
ATOM   1409 N N    . SER A  1 209 ? 111.016 138.198 121.601 1.00 81.75  ? 209 SER U N    1 
ATOM   1410 C CA   . SER A  1 209 ? 110.801 137.625 120.277 1.00 69.83  ? 209 SER U CA   1 
ATOM   1411 C C    . SER A  1 209 ? 109.929 138.527 119.417 1.00 69.94  ? 209 SER U C    1 
ATOM   1412 O O    . SER A  1 209 ? 110.217 138.734 118.234 1.00 78.39  ? 209 SER U O    1 
ATOM   1413 C CB   . SER A  1 209 ? 110.177 136.236 120.399 1.00 72.92  ? 209 SER U CB   1 
ATOM   1414 O OG   . SER A  1 209 ? 111.077 135.322 120.995 1.00 81.80  ? 209 SER U OG   1 
ATOM   1415 N N    . CYS A  1 210 ? 108.857 139.082 119.990 1.00 76.40  ? 210 CYS U N    1 
ATOM   1416 C CA   . CYS A  1 210 ? 107.996 139.966 119.213 1.00 73.92  ? 210 CYS U CA   1 
ATOM   1417 C C    . CYS A  1 210 ? 108.733 141.231 118.792 1.00 75.48  ? 210 CYS U C    1 
ATOM   1418 O O    . CYS A  1 210 ? 108.614 141.677 117.643 1.00 74.88  ? 210 CYS U O    1 
ATOM   1419 C CB   . CYS A  1 210 ? 106.738 140.312 120.008 1.00 80.86  ? 210 CYS U CB   1 
ATOM   1420 S SG   . CYS A  1 210 ? 105.617 138.925 120.264 1.00 95.76  ? 210 CYS U SG   1 
ATOM   1421 N N    . CYS A  1 211 ? 109.512 141.820 119.700 1.00 84.14  ? 211 CYS U N    1 
ATOM   1422 C CA   . CYS A  1 211 ? 110.253 143.027 119.352 1.00 81.21  ? 211 CYS U CA   1 
ATOM   1423 C C    . CYS A  1 211 ? 111.289 142.750 118.269 1.00 80.46  ? 211 CYS U C    1 
ATOM   1424 O O    . CYS A  1 211 ? 111.470 143.562 117.355 1.00 82.54  ? 211 CYS U O    1 
ATOM   1425 C CB   . CYS A  1 211 ? 110.918 143.617 120.594 1.00 82.95  ? 211 CYS U CB   1 
ATOM   1426 S SG   . CYS A  1 211 ? 109.760 144.300 121.799 1.00 101.55 ? 211 CYS U SG   1 
ATOM   1427 N N    . ALA A  1 212 ? 111.977 141.609 118.355 1.00 72.40  ? 212 ALA U N    1 
ATOM   1428 C CA   . ALA A  1 212 ? 112.947 141.260 117.320 1.00 69.40  ? 212 ALA U CA   1 
ATOM   1429 C C    . ALA A  1 212 ? 112.268 141.022 115.976 1.00 70.63  ? 212 ALA U C    1 
ATOM   1430 O O    . ALA A  1 212 ? 112.758 141.479 114.940 1.00 71.04  ? 212 ALA U O    1 
ATOM   1431 C CB   . ALA A  1 212 ? 113.746 140.029 117.741 1.00 73.79  ? 212 ALA U CB   1 
ATOM   1432 N N    . SER A  1 213 ? 111.133 140.320 115.978 1.00 77.49  ? 213 SER U N    1 
ATOM   1433 C CA   . SER A  1 213 ? 110.415 140.077 114.735 1.00 68.07  ? 213 SER U CA   1 
ATOM   1434 C C    . SER A  1 213 ? 109.763 141.332 114.184 1.00 69.79  ? 213 SER U C    1 
ATOM   1435 O O    . SER A  1 213 ? 109.361 141.340 113.014 1.00 67.95  ? 213 SER U O    1 
ATOM   1436 C CB   . SER A  1 213 ? 109.356 138.997 114.944 1.00 74.87  ? 213 SER U CB   1 
ATOM   1437 O OG   . SER A  1 213 ? 109.807 138.014 115.859 1.00 83.07  ? 213 SER U OG   1 
ATOM   1438 N N    . ALA A  1 214 ? 109.650 142.393 114.986 1.00 75.54  ? 214 ALA U N    1 
ATOM   1439 C CA   . ALA A  1 214 ? 109.202 143.669 114.437 1.00 72.04  ? 214 ALA U CA   1 
ATOM   1440 C C    . ALA A  1 214 ? 110.143 144.135 113.337 1.00 74.36  ? 214 ALA U C    1 
ATOM   1441 O O    . ALA A  1 214 ? 109.697 144.625 112.294 1.00 77.77  ? 214 ALA U O    1 
ATOM   1442 C CB   . ALA A  1 214 ? 109.104 144.717 115.543 1.00 79.23  ? 214 ALA U CB   1 
ATOM   1443 N N    . MET A  1 215 ? 111.447 143.991 113.552 1.00 82.48  ? 215 MET U N    1 
ATOM   1444 C CA   . MET A  1 215 ? 112.413 144.102 112.475 1.00 83.16  ? 215 MET U CA   1 
ATOM   1445 C C    . MET A  1 215 ? 112.640 142.720 111.863 1.00 89.73  ? 215 MET U C    1 
ATOM   1446 O O    . MET A  1 215 ? 111.995 141.737 112.232 1.00 97.61  ? 215 MET U O    1 
ATOM   1447 C CB   . MET A  1 215 ? 113.718 144.717 112.973 1.00 77.74  ? 215 MET U CB   1 
ATOM   1448 C CG   . MET A  1 215 ? 114.687 143.720 113.578 1.00 82.53  ? 215 MET U CG   1 
ATOM   1449 S SD   . MET A  1 215 ? 116.385 144.317 113.613 1.00 88.79  ? 215 MET U SD   1 
ATOM   1450 C CE   . MET A  1 215 ? 116.123 146.067 113.856 1.00 82.94  ? 215 MET U CE   1 
ATOM   1451 N N    . TYR A  1 216 ? 113.567 142.648 110.912 1.00 69.88  ? 216 TYR U N    1 
ATOM   1452 C CA   . TYR A  1 216 ? 113.803 141.458 110.102 1.00 69.44  ? 216 TYR U CA   1 
ATOM   1453 C C    . TYR A  1 216 ? 112.679 141.234 109.100 1.00 74.01  ? 216 TYR U C    1 
ATOM   1454 O O    . TYR A  1 216 ? 112.824 140.432 108.174 1.00 82.92  ? 216 TYR U O    1 
ATOM   1455 C CB   . TYR A  1 216 ? 113.909 140.194 110.963 1.00 66.56  ? 216 TYR U CB   1 
ATOM   1456 C CG   . TYR A  1 216 ? 115.079 140.103 111.911 1.00 62.70  ? 216 TYR U CG   1 
ATOM   1457 C CD1  . TYR A  1 216 ? 116.206 140.887 111.749 1.00 74.74  ? 216 TYR U CD1  1 
ATOM   1458 C CD2  . TYR A  1 216 ? 115.057 139.198 112.961 1.00 61.70  ? 216 TYR U CD2  1 
ATOM   1459 C CE1  . TYR A  1 216 ? 117.274 140.782 112.619 1.00 76.54  ? 216 TYR U CE1  1 
ATOM   1460 C CE2  . TYR A  1 216 ? 116.111 139.086 113.830 1.00 63.35  ? 216 TYR U CE2  1 
ATOM   1461 C CZ   . TYR A  1 216 ? 117.219 139.878 113.657 1.00 71.44  ? 216 TYR U CZ   1 
ATOM   1462 O OH   . TYR A  1 216 ? 118.273 139.762 114.529 1.00 75.80  ? 216 TYR U OH   1 
ATOM   1463 N N    . THR A  1 217 ? 111.557 141.932 109.269 1.00 75.50  ? 217 THR U N    1 
ATOM   1464 C CA   . THR A  1 217 ? 110.468 141.793 108.310 1.00 75.96  ? 217 THR U CA   1 
ATOM   1465 C C    . THR A  1 217 ? 110.649 142.728 107.122 1.00 83.72  ? 217 THR U C    1 
ATOM   1466 O O    . THR A  1 217 ? 110.572 142.286 105.969 1.00 89.55  ? 217 THR U O    1 
ATOM   1467 C CB   . THR A  1 217 ? 109.123 142.049 108.984 1.00 75.20  ? 217 THR U CB   1 
ATOM   1468 O OG1  . THR A  1 217 ? 108.922 141.088 110.026 1.00 76.67  ? 217 THR U OG1  1 
ATOM   1469 C CG2  . THR A  1 217 ? 107.998 141.930 107.977 1.00 78.16  ? 217 THR U CG2  1 
ATOM   1470 N N    . PRO A  1 218 ? 110.890 144.018 107.356 1.00 79.84  ? 218 PRO U N    1 
ATOM   1471 C CA   . PRO A  1 218 ? 111.089 144.938 106.232 1.00 82.36  ? 218 PRO U CA   1 
ATOM   1472 C C    . PRO A  1 218 ? 112.528 144.993 105.749 1.00 87.49  ? 218 PRO U C    1 
ATOM   1473 O O    . PRO A  1 218 ? 112.778 145.296 104.578 1.00 89.49  ? 218 PRO U O    1 
ATOM   1474 C CB   . PRO A  1 218 ? 110.633 146.278 106.809 1.00 82.76  ? 218 PRO U CB   1 
ATOM   1475 C CG   . PRO A  1 218 ? 110.993 146.181 108.247 1.00 82.65  ? 218 PRO U CG   1 
ATOM   1476 C CD   . PRO A  1 218 ? 110.814 144.733 108.640 1.00 77.14  ? 218 PRO U CD   1 
ATOM   1477 N N    . ILE A  1 219 ? 113.484 144.708 106.633 1.00 84.26  ? 219 ILE U N    1 
ATOM   1478 C CA   . ILE A  1 219 ? 114.890 144.758 106.238 1.00 82.28  ? 219 ILE U CA   1 
ATOM   1479 C C    . ILE A  1 219 ? 115.201 143.627 105.270 1.00 85.92  ? 219 ILE U C    1 
ATOM   1480 O O    . ILE A  1 219 ? 115.853 143.826 104.241 1.00 94.00  ? 219 ILE U O    1 
ATOM   1481 C CB   . ILE A  1 219 ? 115.799 144.711 107.476 1.00 80.27  ? 219 ILE U CB   1 
ATOM   1482 C CG1  . ILE A  1 219 ? 115.603 145.967 108.324 1.00 82.73  ? 219 ILE U CG1  1 
ATOM   1483 C CG2  . ILE A  1 219 ? 117.248 144.579 107.059 1.00 83.53  ? 219 ILE U CG2  1 
ATOM   1484 C CD1  . ILE A  1 219 ? 115.201 147.179 107.524 1.00 82.15  ? 219 ILE U CD1  1 
ATOM   1485 N N    . GLU A  1 220 ? 114.741 142.422 105.593 1.00 76.79  ? 220 GLU U N    1 
ATOM   1486 C CA   . GLU A  1 220 ? 114.858 141.260 104.728 1.00 75.59  ? 220 GLU U CA   1 
ATOM   1487 C C    . GLU A  1 220 ? 113.460 140.719 104.481 1.00 83.62  ? 220 GLU U C    1 
ATOM   1488 O O    . GLU A  1 220 ? 112.707 140.495 105.436 1.00 90.46  ? 220 GLU U O    1 
ATOM   1489 C CB   . GLU A  1 220 ? 115.734 140.183 105.367 1.00 74.03  ? 220 GLU U CB   1 
ATOM   1490 C CG   . GLU A  1 220 ? 117.138 140.645 105.681 1.00 82.44  ? 220 GLU U CG   1 
ATOM   1491 C CD   . GLU A  1 220 ? 117.790 139.812 106.758 1.00 83.01  ? 220 GLU U CD   1 
ATOM   1492 O OE1  . GLU A  1 220 ? 117.061 139.322 107.644 1.00 86.55  ? 220 GLU U OE1  1 
ATOM   1493 O OE2  . GLU A  1 220 ? 119.023 139.644 106.721 1.00 83.08  ? 220 GLU U OE2  1 
ATOM   1494 N N    . GLY A  1 221 ? 113.104 140.510 103.219 1.00 85.99  ? 221 GLY U N    1 
ATOM   1495 C CA   . GLY A  1 221 ? 111.738 140.113 102.960 1.00 82.14  ? 221 GLY U CA   1 
ATOM   1496 C C    . GLY A  1 221 ? 111.503 138.759 103.590 1.00 84.34  ? 221 GLY U C    1 
ATOM   1497 O O    . GLY A  1 221 ? 112.100 137.764 103.172 1.00 90.58  ? 221 GLY U O    1 
ATOM   1498 N N    . TRP A  1 222 ? 110.587 138.708 104.553 1.00 74.29  ? 222 TRP U N    1 
ATOM   1499 C CA   . TRP A  1 222 ? 110.201 137.491 105.253 1.00 75.15  ? 222 TRP U CA   1 
ATOM   1500 C C    . TRP A  1 222 ? 108.788 137.682 105.774 1.00 79.85  ? 222 TRP U C    1 
ATOM   1501 O O    . TRP A  1 222 ? 108.313 138.809 105.929 1.00 87.95  ? 222 TRP U O    1 
ATOM   1502 C CB   . TRP A  1 222 ? 111.139 137.186 106.432 1.00 67.82  ? 222 TRP U CB   1 
ATOM   1503 C CG   . TRP A  1 222 ? 112.453 136.512 106.126 1.00 68.23  ? 222 TRP U CG   1 
ATOM   1504 C CD1  . TRP A  1 222 ? 112.846 135.960 104.947 1.00 75.76  ? 222 TRP U CD1  1 
ATOM   1505 C CD2  . TRP A  1 222 ? 113.551 136.341 107.032 1.00 70.97  ? 222 TRP U CD2  1 
ATOM   1506 N NE1  . TRP A  1 222 ? 114.118 135.454 105.061 1.00 72.30  ? 222 TRP U NE1  1 
ATOM   1507 C CE2  . TRP A  1 222 ? 114.571 135.677 106.332 1.00 70.51  ? 222 TRP U CE2  1 
ATOM   1508 C CE3  . TRP A  1 222 ? 113.768 136.689 108.368 1.00 73.39  ? 222 TRP U CE3  1 
ATOM   1509 C CZ2  . TRP A  1 222 ? 115.787 135.347 106.920 1.00 72.77  ? 222 TRP U CZ2  1 
ATOM   1510 C CZ3  . TRP A  1 222 ? 114.976 136.363 108.951 1.00 67.42  ? 222 TRP U CZ3  1 
ATOM   1511 C CH2  . TRP A  1 222 ? 115.970 135.699 108.228 1.00 71.01  ? 222 TRP U CH2  1 
ATOM   1512 N N    . SER A  1 223 ? 108.120 136.568 106.044 1.00 74.70  ? 223 SER U N    1 
ATOM   1513 C CA   . SER A  1 223 ? 106.855 136.642 106.752 1.00 68.58  ? 223 SER U CA   1 
ATOM   1514 C C    . SER A  1 223 ? 107.107 136.831 108.243 1.00 75.82  ? 223 SER U C    1 
ATOM   1515 O O    . SER A  1 223 ? 108.191 136.543 108.757 1.00 85.26  ? 223 SER U O    1 
ATOM   1516 C CB   . SER A  1 223 ? 106.025 135.385 106.516 1.00 76.68  ? 223 SER U CB   1 
ATOM   1517 O OG   . SER A  1 223 ? 106.193 134.902 105.196 1.00 89.75  ? 223 SER U OG   1 
ATOM   1518 N N    . TYR A  1 224 ? 106.088 137.329 108.941 1.00 68.98  ? 224 TYR U N    1 
ATOM   1519 C CA   . TYR A  1 224 ? 106.206 137.495 110.385 1.00 71.58  ? 224 TYR U CA   1 
ATOM   1520 C C    . TYR A  1 224 ? 106.402 136.149 111.073 1.00 78.02  ? 224 TYR U C    1 
ATOM   1521 O O    . TYR A  1 224 ? 107.222 136.019 111.996 1.00 81.27  ? 224 TYR U O    1 
ATOM   1522 C CB   . TYR A  1 224 ? 104.971 138.211 110.924 1.00 70.49  ? 224 TYR U CB   1 
ATOM   1523 C CG   . TYR A  1 224 ? 105.171 138.883 112.259 1.00 73.99  ? 224 TYR U CG   1 
ATOM   1524 C CD1  . TYR A  1 224 ? 105.636 140.186 112.336 1.00 75.45  ? 224 TYR U CD1  1 
ATOM   1525 C CD2  . TYR A  1 224 ? 104.887 138.220 113.441 1.00 81.04  ? 224 TYR U CD2  1 
ATOM   1526 C CE1  . TYR A  1 224 ? 105.820 140.806 113.555 1.00 80.99  ? 224 TYR U CE1  1 
ATOM   1527 C CE2  . TYR A  1 224 ? 105.068 138.830 114.664 1.00 75.00  ? 224 TYR U CE2  1 
ATOM   1528 C CZ   . TYR A  1 224 ? 105.535 140.123 114.714 1.00 77.76  ? 224 TYR U CZ   1 
ATOM   1529 O OH   . TYR A  1 224 ? 105.714 140.735 115.932 1.00 79.61  ? 224 TYR U OH   1 
ATOM   1530 N N    . PHE A  1 225 ? 105.675 135.127 110.621 1.00 75.89  ? 225 PHE U N    1 
ATOM   1531 C CA   . PHE A  1 225 ? 105.829 133.798 111.201 1.00 74.24  ? 225 PHE U CA   1 
ATOM   1532 C C    . PHE A  1 225 ? 107.219 133.235 110.934 1.00 76.45  ? 225 PHE U C    1 
ATOM   1533 O O    . PHE A  1 225 ? 107.790 132.548 111.791 1.00 81.66  ? 225 PHE U O    1 
ATOM   1534 C CB   . PHE A  1 225 ? 104.752 132.860 110.656 1.00 75.71  ? 225 PHE U CB   1 
ATOM   1535 C CG   . PHE A  1 225 ? 104.813 131.472 111.224 1.00 79.70  ? 225 PHE U CG   1 
ATOM   1536 C CD1  . PHE A  1 225 ? 104.628 131.256 112.577 1.00 76.39  ? 225 PHE U CD1  1 
ATOM   1537 C CD2  . PHE A  1 225 ? 105.053 130.385 110.405 1.00 77.98  ? 225 PHE U CD2  1 
ATOM   1538 C CE1  . PHE A  1 225 ? 104.687 129.982 113.101 1.00 71.90  ? 225 PHE U CE1  1 
ATOM   1539 C CE2  . PHE A  1 225 ? 105.110 129.110 110.926 1.00 75.06  ? 225 PHE U CE2  1 
ATOM   1540 C CZ   . PHE A  1 225 ? 104.927 128.909 112.274 1.00 74.22  ? 225 PHE U CZ   1 
ATOM   1541 N N    . ASP A  1 226 ? 107.781 133.510 109.757 1.00 72.09  ? 226 ASP U N    1 
ATOM   1542 C CA   . ASP A  1 226 ? 109.153 133.093 109.495 1.00 70.13  ? 226 ASP U CA   1 
ATOM   1543 C C    . ASP A  1 226 ? 110.129 133.774 110.443 1.00 71.21  ? 226 ASP U C    1 
ATOM   1544 O O    . ASP A  1 226 ? 111.094 133.157 110.907 1.00 77.82  ? 226 ASP U O    1 
ATOM   1545 C CB   . ASP A  1 226 ? 109.529 133.386 108.043 1.00 74.84  ? 226 ASP U CB   1 
ATOM   1546 C CG   . ASP A  1 226 ? 108.962 132.364 107.081 1.00 78.50  ? 226 ASP U CG   1 
ATOM   1547 O OD1  . ASP A  1 226 ? 108.160 131.514 107.518 1.00 82.42  ? 226 ASP U OD1  1 
ATOM   1548 O OD2  . ASP A  1 226 ? 109.324 132.406 105.884 1.00 77.02  ? 226 ASP U OD2  1 
ATOM   1549 N N    . SER A  1 227 ? 109.897 135.054 110.744 1.00 63.67  ? 227 SER U N    1 
ATOM   1550 C CA   . SER A  1 227 ? 110.749 135.745 111.702 1.00 65.04  ? 227 SER U CA   1 
ATOM   1551 C C    . SER A  1 227 ? 110.655 135.108 113.081 1.00 72.36  ? 227 SER U C    1 
ATOM   1552 O O    . SER A  1 227 ? 111.670 134.921 113.757 1.00 74.68  ? 227 SER U O    1 
ATOM   1553 C CB   . SER A  1 227 ? 110.370 137.224 111.768 1.00 70.20  ? 227 SER U CB   1 
ATOM   1554 O OG   . SER A  1 227 ? 110.461 137.825 110.489 1.00 78.62  ? 227 SER U OG   1 
ATOM   1555 N N    . LEU A  1 228 ? 109.438 134.767 113.519 1.00 70.62  ? 228 LEU U N    1 
ATOM   1556 C CA   . LEU A  1 228 ? 109.287 134.113 114.817 1.00 60.35  ? 228 LEU U CA   1 
ATOM   1557 C C    . LEU A  1 228 ? 109.977 132.753 114.836 1.00 63.01  ? 228 LEU U C    1 
ATOM   1558 O O    . LEU A  1 228 ? 110.623 132.383 115.826 1.00 70.50  ? 228 LEU U O    1 
ATOM   1559 C CB   . LEU A  1 228 ? 107.808 133.971 115.166 1.00 58.56  ? 228 LEU U CB   1 
ATOM   1560 C CG   . LEU A  1 228 ? 107.048 135.269 115.427 1.00 64.95  ? 228 LEU U CG   1 
ATOM   1561 C CD1  . LEU A  1 228 ? 105.568 134.997 115.630 1.00 64.34  ? 228 LEU U CD1  1 
ATOM   1562 C CD2  . LEU A  1 228 ? 107.624 135.987 116.630 1.00 67.88  ? 228 LEU U CD2  1 
ATOM   1563 N N    . TYR A  1 229 ? 109.846 131.991 113.749 1.00 58.76  ? 229 TYR U N    1 
ATOM   1564 C CA   . TYR A  1 229 ? 110.499 130.689 113.664 1.00 58.62  ? 229 TYR U CA   1 
ATOM   1565 C C    . TYR A  1 229 ? 112.014 130.827 113.733 1.00 65.41  ? 229 TYR U C    1 
ATOM   1566 O O    . TYR A  1 229 ? 112.683 130.066 114.446 1.00 72.74  ? 229 TYR U O    1 
ATOM   1567 C CB   . TYR A  1 229 ? 110.067 129.992 112.375 1.00 59.78  ? 229 TYR U CB   1 
ATOM   1568 C CG   . TYR A  1 229 ? 110.756 128.676 112.089 1.00 61.69  ? 229 TYR U CG   1 
ATOM   1569 C CD1  . TYR A  1 229 ? 110.476 127.549 112.842 1.00 54.61  ? 229 TYR U CD1  1 
ATOM   1570 C CD2  . TYR A  1 229 ? 111.663 128.561 111.048 1.00 68.70  ? 229 TYR U CD2  1 
ATOM   1571 C CE1  . TYR A  1 229 ? 111.095 126.347 112.578 1.00 60.12  ? 229 TYR U CE1  1 
ATOM   1572 C CE2  . TYR A  1 229 ? 112.287 127.366 110.776 1.00 64.34  ? 229 TYR U CE2  1 
ATOM   1573 C CZ   . TYR A  1 229 ? 111.998 126.261 111.544 1.00 66.60  ? 229 TYR U CZ   1 
ATOM   1574 O OH   . TYR A  1 229 ? 112.621 125.063 111.275 1.00 70.10  ? 229 TYR U OH   1 
ATOM   1575 N N    . PHE A  1 230 ? 112.571 131.799 113.011 1.00 62.31  ? 230 PHE U N    1 
ATOM   1576 C CA   . PHE A  1 230 ? 114.011 132.029 113.077 1.00 57.88  ? 230 PHE U CA   1 
ATOM   1577 C C    . PHE A  1 230 ? 114.438 132.435 114.481 1.00 62.58  ? 230 PHE U C    1 
ATOM   1578 O O    . PHE A  1 230 ? 115.476 131.978 114.975 1.00 67.59  ? 230 PHE U O    1 
ATOM   1579 C CB   . PHE A  1 230 ? 114.427 133.099 112.072 1.00 59.81  ? 230 PHE U CB   1 
ATOM   1580 C CG   . PHE A  1 230 ? 115.797 133.657 112.318 1.00 62.89  ? 230 PHE U CG   1 
ATOM   1581 C CD1  . PHE A  1 230 ? 116.926 132.917 112.019 1.00 68.31  ? 230 PHE U CD1  1 
ATOM   1582 C CD2  . PHE A  1 230 ? 115.956 134.917 112.859 1.00 61.70  ? 230 PHE U CD2  1 
ATOM   1583 C CE1  . PHE A  1 230 ? 118.185 133.428 112.251 1.00 62.17  ? 230 PHE U CE1  1 
ATOM   1584 C CE2  . PHE A  1 230 ? 117.214 135.430 113.094 1.00 65.45  ? 230 PHE U CE2  1 
ATOM   1585 C CZ   . PHE A  1 230 ? 118.329 134.683 112.788 1.00 62.74  ? 230 PHE U CZ   1 
ATOM   1586 N N    . CYS A  1 231 ? 113.658 133.300 115.130 1.00 63.32  ? 231 CYS U N    1 
ATOM   1587 C CA   . CYS A  1 231 ? 114.011 133.724 116.480 1.00 53.69  ? 231 CYS U CA   1 
ATOM   1588 C C    . CYS A  1 231 ? 114.037 132.543 117.439 1.00 57.74  ? 231 CYS U C    1 
ATOM   1589 O O    . CYS A  1 231 ? 114.960 132.416 118.250 1.00 68.74  ? 231 CYS U O    1 
ATOM   1590 C CB   . CYS A  1 231 ? 113.036 134.794 116.969 1.00 56.37  ? 231 CYS U CB   1 
ATOM   1591 S SG   . CYS A  1 231 ? 113.243 136.405 116.189 1.00 80.55  ? 231 CYS U SG   1 
ATOM   1592 N N    . PHE A  1 232 ? 113.043 131.658 117.356 1.00 56.14  ? 232 PHE U N    1 
ATOM   1593 C CA   . PHE A  1 232 ? 113.046 130.500 118.245 1.00 51.57  ? 232 PHE U CA   1 
ATOM   1594 C C    . PHE A  1 232 ? 114.202 129.563 117.936 1.00 54.31  ? 232 PHE U C    1 
ATOM   1595 O O    . PHE A  1 232 ? 114.839 129.036 118.856 1.00 58.29  ? 232 PHE U O    1 
ATOM   1596 C CB   . PHE A  1 232 ? 111.727 129.740 118.166 1.00 51.71  ? 232 PHE U CB   1 
ATOM   1597 C CG   . PHE A  1 232 ? 111.728 128.471 118.971 1.00 60.17  ? 232 PHE U CG   1 
ATOM   1598 C CD1  . PHE A  1 232 ? 111.667 128.514 120.352 1.00 59.99  ? 232 PHE U CD1  1 
ATOM   1599 C CD2  . PHE A  1 232 ? 111.815 127.239 118.349 1.00 60.00  ? 232 PHE U CD2  1 
ATOM   1600 C CE1  . PHE A  1 232 ? 111.684 127.354 121.098 1.00 55.28  ? 232 PHE U CE1  1 
ATOM   1601 C CE2  . PHE A  1 232 ? 111.833 126.073 119.091 1.00 56.71  ? 232 PHE U CE2  1 
ATOM   1602 C CZ   . PHE A  1 232 ? 111.763 126.132 120.466 1.00 51.52  ? 232 PHE U CZ   1 
ATOM   1603 N N    . VAL A  1 233 ? 114.489 129.329 116.654 1.00 57.76  ? 233 VAL U N    1 
ATOM   1604 C CA   . VAL A  1 233 ? 115.566 128.403 116.310 1.00 51.27  ? 233 VAL U CA   1 
ATOM   1605 C C    . VAL A  1 233 ? 116.912 128.947 116.769 1.00 58.34  ? 233 VAL U C    1 
ATOM   1606 O O    . VAL A  1 233 ? 117.766 128.194 117.252 1.00 58.62  ? 233 VAL U O    1 
ATOM   1607 C CB   . VAL A  1 233 ? 115.557 128.111 114.799 1.00 53.26  ? 233 VAL U CB   1 
ATOM   1608 C CG1  . VAL A  1 233 ? 116.788 127.314 114.414 1.00 54.92  ? 233 VAL U CG1  1 
ATOM   1609 C CG2  . VAL A  1 233 ? 114.301 127.359 114.418 1.00 55.85  ? 233 VAL U CG2  1 
ATOM   1610 N N    . ALA A  1 234 ? 117.134 130.255 116.620 1.00 58.61  ? 234 ALA U N    1 
ATOM   1611 C CA   . ALA A  1 234 ? 118.415 130.837 117.010 1.00 51.24  ? 234 ALA U CA   1 
ATOM   1612 C C    . ALA A  1 234 ? 118.551 130.942 118.525 1.00 52.29  ? 234 ALA U C    1 
ATOM   1613 O O    . ALA A  1 234 ? 119.618 130.646 119.077 1.00 58.36  ? 234 ALA U O    1 
ATOM   1614 C CB   . ALA A  1 234 ? 118.587 132.207 116.363 1.00 48.64  ? 234 ALA U CB   1 
ATOM   1615 N N    . PHE A  1 235 ? 117.489 131.361 119.219 1.00 55.61  ? 235 PHE U N    1 
ATOM   1616 C CA   . PHE A  1 235 ? 117.594 131.599 120.656 1.00 48.82  ? 235 PHE U CA   1 
ATOM   1617 C C    . PHE A  1 235 ? 117.841 130.306 121.423 1.00 52.74  ? 235 PHE U C    1 
ATOM   1618 O O    . PHE A  1 235 ? 118.575 130.298 122.415 1.00 52.02  ? 235 PHE U O    1 
ATOM   1619 C CB   . PHE A  1 235 ? 116.335 132.292 121.169 1.00 48.84  ? 235 PHE U CB   1 
ATOM   1620 C CG   . PHE A  1 235 ? 116.195 133.717 120.716 1.00 58.06  ? 235 PHE U CG   1 
ATOM   1621 C CD1  . PHE A  1 235 ? 117.269 134.391 120.165 1.00 58.74  ? 235 PHE U CD1  1 
ATOM   1622 C CD2  . PHE A  1 235 ? 114.991 134.384 120.846 1.00 58.21  ? 235 PHE U CD2  1 
ATOM   1623 C CE1  . PHE A  1 235 ? 117.142 135.697 119.747 1.00 59.05  ? 235 PHE U CE1  1 
ATOM   1624 C CE2  . PHE A  1 235 ? 114.862 135.693 120.430 1.00 54.94  ? 235 PHE U CE2  1 
ATOM   1625 C CZ   . PHE A  1 235 ? 115.939 136.349 119.882 1.00 58.45  ? 235 PHE U CZ   1 
ATOM   1626 N N    . SER A  1 236 ? 117.235 129.204 120.986 1.00 56.65  ? 236 SER U N    1 
ATOM   1627 C CA   . SER A  1 236 ? 117.395 127.929 121.672 1.00 52.12  ? 236 SER U CA   1 
ATOM   1628 C C    . SER A  1 236 ? 118.735 127.266 121.387 1.00 60.74  ? 236 SER U C    1 
ATOM   1629 O O    . SER A  1 236 ? 118.961 126.145 121.850 1.00 64.96  ? 236 SER U O    1 
ATOM   1630 C CB   . SER A  1 236 ? 116.260 126.979 121.281 1.00 50.46  ? 236 SER U CB   1 
ATOM   1631 O OG   . SER A  1 236 ? 116.306 126.678 119.900 1.00 54.97  ? 236 SER U OG   1 
ATOM   1632 N N    . THR A  1 237 ? 119.624 127.932 120.655 1.00 64.96  ? 237 THR U N    1 
ATOM   1633 C CA   . THR A  1 237 ? 120.937 127.395 120.303 1.00 55.53  ? 237 THR U CA   1 
ATOM   1634 C C    . THR A  1 237 ? 120.830 126.092 119.516 1.00 58.85  ? 237 THR U C    1 
ATOM   1635 O O    . THR A  1 237 ? 121.699 125.225 119.611 1.00 71.30  ? 237 THR U O    1 
ATOM   1636 C CB   . THR A  1 237 ? 121.806 127.181 121.541 1.00 55.06  ? 237 THR U CB   1 
ATOM   1637 O OG1  . THR A  1 237 ? 121.224 126.167 122.368 1.00 62.45  ? 237 THR U OG1  1 
ATOM   1638 C CG2  . THR A  1 237 ? 121.929 128.468 122.334 1.00 54.44  ? 237 THR U CG2  1 
ATOM   1639 N N    . ILE A  1 238 ? 119.767 125.940 118.728 1.00 45.89  ? 238 ILE U N    1 
ATOM   1640 C CA   . ILE A  1 238 ? 119.686 124.815 117.801 1.00 51.79  ? 238 ILE U CA   1 
ATOM   1641 C C    . ILE A  1 238 ? 120.420 125.140 116.508 1.00 58.68  ? 238 ILE U C    1 
ATOM   1642 O O    . ILE A  1 238 ? 121.372 124.452 116.123 1.00 64.79  ? 238 ILE U O    1 
ATOM   1643 C CB   . ILE A  1 238 ? 118.215 124.431 117.536 1.00 48.78  ? 238 ILE U CB   1 
ATOM   1644 C CG1  . ILE A  1 238 ? 117.584 123.849 118.799 1.00 50.04  ? 238 ILE U CG1  1 
ATOM   1645 C CG2  . ILE A  1 238 ? 118.121 123.434 116.399 1.00 44.72  ? 238 ILE U CG2  1 
ATOM   1646 C CD1  . ILE A  1 238 ? 116.159 123.394 118.609 1.00 53.94  ? 238 ILE U CD1  1 
ATOM   1647 N N    . GLY A  1 239 ? 119.993 126.199 115.827 1.00 55.43  ? 239 GLY U N    1 
ATOM   1648 C CA   . GLY A  1 239 ? 120.709 126.700 114.671 1.00 48.05  ? 239 GLY U CA   1 
ATOM   1649 C C    . GLY A  1 239 ? 120.714 125.770 113.477 1.00 55.22  ? 239 GLY U C    1 
ATOM   1650 O O    . GLY A  1 239 ? 121.764 125.237 113.107 1.00 66.97  ? 239 GLY U O    1 
ATOM   1651 N N    . PHE A  1 240 ? 119.551 125.569 112.860 1.00 58.74  ? 240 PHE U N    1 
ATOM   1652 C CA   . PHE A  1 240 ? 119.491 124.732 111.666 1.00 55.60  ? 240 PHE U CA   1 
ATOM   1653 C C    . PHE A  1 240 ? 120.330 125.323 110.539 1.00 57.92  ? 240 PHE U C    1 
ATOM   1654 O O    . PHE A  1 240 ? 121.079 124.604 109.870 1.00 63.31  ? 240 PHE U O    1 
ATOM   1655 C CB   . PHE A  1 240 ? 118.043 124.552 111.217 1.00 53.88  ? 240 PHE U CB   1 
ATOM   1656 C CG   . PHE A  1 240 ? 117.247 123.632 112.090 1.00 54.97  ? 240 PHE U CG   1 
ATOM   1657 C CD1  . PHE A  1 240 ? 117.834 122.515 112.653 1.00 57.06  ? 240 PHE U CD1  1 
ATOM   1658 C CD2  . PHE A  1 240 ? 115.914 123.883 112.349 1.00 56.92  ? 240 PHE U CD2  1 
ATOM   1659 C CE1  . PHE A  1 240 ? 117.099 121.667 113.456 1.00 59.09  ? 240 PHE U CE1  1 
ATOM   1660 C CE2  . PHE A  1 240 ? 115.178 123.036 113.149 1.00 56.69  ? 240 PHE U CE2  1 
ATOM   1661 C CZ   . PHE A  1 240 ? 115.773 121.928 113.704 1.00 55.06  ? 240 PHE U CZ   1 
ATOM   1662 N N    . GLY A  1 241 ? 120.223 126.629 110.321 1.00 63.69  ? 241 GLY U N    1 
ATOM   1663 C CA   . GLY A  1 241 ? 120.966 127.296 109.275 1.00 61.94  ? 241 GLY U CA   1 
ATOM   1664 C C    . GLY A  1 241 ? 120.193 127.573 108.007 1.00 64.93  ? 241 GLY U C    1 
ATOM   1665 O O    . GLY A  1 241 ? 120.760 128.155 107.076 1.00 67.45  ? 241 GLY U O    1 
ATOM   1666 N N    . ASP A  1 242 ? 118.923 127.173 107.934 1.00 75.53  ? 242 ASP U N    1 
ATOM   1667 C CA   . ASP A  1 242 ? 118.127 127.463 106.747 1.00 72.10  ? 242 ASP U CA   1 
ATOM   1668 C C    . ASP A  1 242 ? 117.840 128.952 106.613 1.00 75.64  ? 242 ASP U C    1 
ATOM   1669 O O    . ASP A  1 242 ? 117.773 129.470 105.495 1.00 80.74  ? 242 ASP U O    1 
ATOM   1670 C CB   . ASP A  1 242 ? 116.822 126.668 106.779 1.00 72.77  ? 242 ASP U CB   1 
ATOM   1671 C CG   . ASP A  1 242 ? 116.065 126.843 108.077 1.00 83.57  ? 242 ASP U CG   1 
ATOM   1672 O OD1  . ASP A  1 242 ? 116.645 127.400 109.031 1.00 88.01  ? 242 ASP U OD1  1 
ATOM   1673 O OD2  . ASP A  1 242 ? 114.892 126.425 108.147 1.00 83.90  ? 242 ASP U OD2  1 
ATOM   1674 N N    . LEU A  1 243 ? 117.665 129.652 107.733 1.00 72.46  ? 243 LEU U N    1 
ATOM   1675 C CA   . LEU A  1 243 ? 117.486 131.097 107.746 1.00 68.52  ? 243 LEU U CA   1 
ATOM   1676 C C    . LEU A  1 243 ? 118.588 131.718 108.590 1.00 69.90  ? 243 LEU U C    1 
ATOM   1677 O O    . LEU A  1 243 ? 118.685 131.443 109.790 1.00 78.71  ? 243 LEU U O    1 
ATOM   1678 C CB   . LEU A  1 243 ? 116.114 131.479 108.300 1.00 67.09  ? 243 LEU U CB   1 
ATOM   1679 C CG   . LEU A  1 243 ? 114.884 131.013 107.522 1.00 65.94  ? 243 LEU U CG   1 
ATOM   1680 C CD1  . LEU A  1 243 ? 113.614 131.398 108.256 1.00 62.27  ? 243 LEU U CD1  1 
ATOM   1681 C CD2  . LEU A  1 243 ? 114.892 131.595 106.124 1.00 67.98  ? 243 LEU U CD2  1 
ATOM   1682 N N    . VAL A  1 244 ? 119.416 132.550 107.966 1.00 63.76  ? 244 VAL U N    1 
ATOM   1683 C CA   . VAL A  1 244 ? 120.472 133.282 108.652 1.00 65.34  ? 244 VAL U CA   1 
ATOM   1684 C C    . VAL A  1 244 ? 120.326 134.757 108.319 1.00 70.35  ? 244 VAL U C    1 
ATOM   1685 O O    . VAL A  1 244 ? 120.079 135.123 107.164 1.00 72.05  ? 244 VAL U O    1 
ATOM   1686 C CB   . VAL A  1 244 ? 121.876 132.772 108.267 1.00 64.60  ? 244 VAL U CB   1 
ATOM   1687 C CG1  . VAL A  1 244 ? 122.931 133.478 109.092 1.00 62.36  ? 244 VAL U CG1  1 
ATOM   1688 C CG2  . VAL A  1 244 ? 121.966 131.272 108.461 1.00 67.59  ? 244 VAL U CG2  1 
ATOM   1689 N N    . SER A  1 245 ? 120.473 135.605 109.329 1.00 71.80  ? 245 SER U N    1 
ATOM   1690 C CA   . SER A  1 245 ? 120.221 137.030 109.198 1.00 68.27  ? 245 SER U CA   1 
ATOM   1691 C C    . SER A  1 245 ? 121.499 137.802 108.900 1.00 75.32  ? 245 SER U C    1 
ATOM   1692 O O    . SER A  1 245 ? 122.610 137.371 109.218 1.00 77.64  ? 245 SER U O    1 
ATOM   1693 C CB   . SER A  1 245 ? 119.575 137.576 110.476 1.00 67.15  ? 245 SER U CB   1 
ATOM   1694 O OG   . SER A  1 245 ? 119.322 138.962 110.363 1.00 71.84  ? 245 SER U OG   1 
ATOM   1695 N N    . SER A  1 246 ? 121.319 138.968 108.281 1.00 72.19  ? 246 SER U N    1 
ATOM   1696 C CA   . SER A  1 246 ? 122.384 139.949 108.089 1.00 63.20  ? 246 SER U CA   1 
ATOM   1697 C C    . SER A  1 246 ? 123.508 139.416 107.199 1.00 65.48  ? 246 SER U C    1 
ATOM   1698 O O    . SER A  1 246 ? 124.675 139.373 107.586 1.00 74.17  ? 246 SER U O    1 
ATOM   1699 C CB   . SER A  1 246 ? 122.938 140.411 109.439 1.00 69.94  ? 246 SER U CB   1 
ATOM   1700 O OG   . SER A  1 246 ? 124.059 141.255 109.265 1.00 71.49  ? 246 SER U OG   1 
ATOM   1701 N N    . GLN A  1 247 ? 123.134 139.006 105.983 1.00 68.41  ? 247 GLN U N    1 
ATOM   1702 C CA   . GLN A  1 247 ? 124.138 138.761 104.943 1.00 72.84  ? 247 GLN U CA   1 
ATOM   1703 C C    . GLN A  1 247 ? 123.492 139.019 103.581 1.00 72.22  ? 247 GLN U C    1 
ATOM   1704 O O    . GLN A  1 247 ? 122.874 138.126 102.994 1.00 80.40  ? 247 GLN U O    1 
ATOM   1705 C CB   . GLN A  1 247 ? 124.718 137.360 105.040 1.00 67.99  ? 247 GLN U CB   1 
ATOM   1706 C CG   . GLN A  1 247 ? 123.794 136.340 105.658 1.00 66.75  ? 247 GLN U CG   1 
ATOM   1707 C CD   . GLN A  1 247 ? 124.519 135.058 105.992 1.00 76.81  ? 247 GLN U CD   1 
ATOM   1708 O OE1  . GLN A  1 247 ? 125.435 135.048 106.811 1.00 76.79  ? 247 GLN U OE1  1 
ATOM   1709 N NE2  . GLN A  1 247 ? 124.120 133.967 105.350 1.00 78.00  ? 247 GLN U NE2  1 
ATOM   1710 N N    . ASN A  1 248 ? 123.650 140.249 103.087 1.00 71.45  ? 248 ASN U N    1 
ATOM   1711 C CA   . ASN A  1 248 ? 123.147 140.608 101.765 1.00 74.58  ? 248 ASN U CA   1 
ATOM   1712 C C    . ASN A  1 248 ? 124.107 141.519 101.010 1.00 82.49  ? 248 ASN U C    1 
ATOM   1713 O O    . ASN A  1 248 ? 123.743 142.018 99.936  1.00 86.91  ? 248 ASN U O    1 
ATOM   1714 C CB   . ASN A  1 248 ? 121.775 141.281 101.875 1.00 75.93  ? 248 ASN U CB   1 
ATOM   1715 C CG   . ASN A  1 248 ? 120.634 140.329 101.590 1.00 76.32  ? 248 ASN U CG   1 
ATOM   1716 O OD1  . ASN A  1 248 ? 120.836 139.121 101.474 1.00 78.51  ? 248 ASN U OD1  1 
ATOM   1717 N ND2  . ASN A  1 248 ? 119.428 140.867 101.474 1.00 78.33  ? 248 ASN U ND2  1 
ATOM   1718 N N    . ALA A  1 249 ? 125.307 141.754 101.531 1.00 87.58  ? 249 ALA U N    1 
ATOM   1719 C CA   . ALA A  1 249 ? 126.325 142.564 100.872 1.00 88.97  ? 249 ALA U CA   1 
ATOM   1720 C C    . ALA A  1 249 ? 125.947 144.039 100.824 1.00 89.52  ? 249 ALA U C    1 
ATOM   1721 O O    . ALA A  1 249 ? 126.754 144.873 100.405 1.00 94.16  ? 249 ALA U O    1 
ATOM   1722 C CB   . ALA A  1 249 ? 126.578 142.046 99.456  1.00 85.63  ? 249 ALA U CB   1 
ATOM   1723 N N    . HIS A  1 250 ? 124.731 144.373 101.251 1.00 91.51  ? 250 HIS U N    1 
ATOM   1724 C CA   . HIS A  1 250 ? 124.332 145.770 101.380 1.00 90.21  ? 250 HIS U CA   1 
ATOM   1725 C C    . HIS A  1 250 ? 123.040 145.881 102.174 1.00 93.55  ? 250 HIS U C    1 
ATOM   1726 O O    . HIS A  1 250 ? 122.031 145.274 101.806 1.00 95.54  ? 250 HIS U O    1 
ATOM   1727 C CB   . HIS A  1 250 ? 124.180 146.417 100.003 1.00 92.19  ? 250 HIS U CB   1 
ATOM   1728 C CG   . HIS A  1 250 ? 124.166 147.913 100.038 1.00 96.52  ? 250 HIS U CG   1 
ATOM   1729 N ND1  . HIS A  1 250 ? 125.260 148.655 100.419 1.00 96.05  ? 250 HIS U ND1  1 
ATOM   1730 C CD2  . HIS A  1 250 ? 123.191 148.804 99.742  1.00 97.45  ? 250 HIS U CD2  1 
ATOM   1731 C CE1  . HIS A  1 250 ? 124.962 149.939 100.353 1.00 96.76  ? 250 HIS U CE1  1 
ATOM   1732 N NE2  . HIS A  1 250 ? 123.712 150.058 99.947  1.00 98.67  ? 250 HIS U NE2  1 
ATOM   1733 N N    . TYR A  1 251 ? 123.049 146.658 103.253 1.00 81.22  ? 251 TYR U N    1 
ATOM   1734 C CA   . TYR A  1 251 ? 121.896 146.764 104.143 1.00 78.87  ? 251 TYR U CA   1 
ATOM   1735 C C    . TYR A  1 251 ? 121.635 148.219 104.506 1.00 81.36  ? 251 TYR U C    1 
ATOM   1736 O O    . TYR A  1 251 ? 121.485 148.572 105.676 1.00 90.04  ? 251 TYR U O    1 
ATOM   1737 C CB   . TYR A  1 251 ? 122.097 145.928 105.404 1.00 80.16  ? 251 TYR U CB   1 
ATOM   1738 C CG   . TYR A  1 251 ? 121.591 144.512 105.295 1.00 78.70  ? 251 TYR U CG   1 
ATOM   1739 C CD1  . TYR A  1 251 ? 120.235 144.250 105.184 1.00 76.88  ? 251 TYR U CD1  1 
ATOM   1740 C CD2  . TYR A  1 251 ? 122.466 143.438 105.315 1.00 79.62  ? 251 TYR U CD2  1 
ATOM   1741 C CE1  . TYR A  1 251 ? 119.767 142.960 105.087 1.00 77.73  ? 251 TYR U CE1  1 
ATOM   1742 C CE2  . TYR A  1 251 ? 122.005 142.146 105.220 1.00 78.78  ? 251 TYR U CE2  1 
ATOM   1743 C CZ   . TYR A  1 251 ? 120.655 141.912 105.107 1.00 78.51  ? 251 TYR U CZ   1 
ATOM   1744 O OH   . TYR A  1 251 ? 120.191 140.623 105.012 1.00 84.98  ? 251 TYR U OH   1 
ATOM   1745 N N    . GLU A  1 252 ? 121.544 149.083 103.496 1.00 93.29  ? 252 GLU U N    1 
ATOM   1746 C CA   . GLU A  1 252 ? 121.380 150.507 103.753 1.00 95.71  ? 252 GLU U CA   1 
ATOM   1747 C C    . GLU A  1 252 ? 122.375 150.956 104.814 1.00 100.20 ? 252 GLU U C    1 
ATOM   1748 O O    . GLU A  1 252 ? 123.587 150.944 104.575 1.00 104.58 ? 252 GLU U O    1 
ATOM   1749 C CB   . GLU A  1 252 ? 119.949 150.819 104.197 1.00 92.78  ? 252 GLU U CB   1 
ATOM   1750 C CG   . GLU A  1 252 ? 119.454 152.175 103.747 1.00 96.09  ? 252 GLU U CG   1 
ATOM   1751 C CD   . GLU A  1 252 ? 119.333 152.279 102.241 1.00 102.63 ? 252 GLU U CD   1 
ATOM   1752 O OE1  . GLU A  1 252 ? 120.363 152.519 101.576 1.00 102.79 ? 252 GLU U OE1  1 
ATOM   1753 O OE2  . GLU A  1 252 ? 118.209 152.121 101.720 1.00 104.28 ? 252 GLU U OE2  1 
ATOM   1754 N N    . SER A  1 253 ? 121.876 151.372 105.981 1.00 90.61  ? 253 SER U N    1 
ATOM   1755 C CA   . SER A  1 253 ? 122.755 151.900 107.020 1.00 88.56  ? 253 SER U CA   1 
ATOM   1756 C C    . SER A  1 253 ? 123.928 150.962 107.277 1.00 91.78  ? 253 SER U C    1 
ATOM   1757 O O    . SER A  1 253 ? 125.081 151.397 107.357 1.00 93.89  ? 253 SER U O    1 
ATOM   1758 C CB   . SER A  1 253 ? 121.963 152.140 108.306 1.00 86.80  ? 253 SER U CB   1 
ATOM   1759 O OG   . SER A  1 253 ? 121.003 153.165 108.130 1.00 90.09  ? 253 SER U OG   1 
ATOM   1760 N N    . GLN A  1 254 ? 123.647 149.667 107.413 1.00 87.83  ? 254 GLN U N    1 
ATOM   1761 C CA   . GLN A  1 254 ? 124.671 148.649 107.653 1.00 81.16  ? 254 GLN U CA   1 
ATOM   1762 C C    . GLN A  1 254 ? 125.518 148.972 108.875 1.00 80.83  ? 254 GLN U C    1 
ATOM   1763 O O    . GLN A  1 254 ? 126.624 148.452 109.034 1.00 86.87  ? 254 GLN U O    1 
ATOM   1764 C CB   . GLN A  1 254 ? 125.566 148.460 106.426 1.00 81.80  ? 254 GLN U CB   1 
ATOM   1765 C CG   . GLN A  1 254 ? 126.292 147.128 106.394 1.00 79.21  ? 254 GLN U CG   1 
ATOM   1766 C CD   . GLN A  1 254 ? 127.371 147.082 105.337 1.00 86.58  ? 254 GLN U CD   1 
ATOM   1767 O OE1  . GLN A  1 254 ? 127.085 147.076 104.140 1.00 90.22  ? 254 GLN U OE1  1 
ATOM   1768 N NE2  . GLN A  1 254 ? 128.623 147.054 105.772 1.00 87.18  ? 254 GLN U NE2  1 
ATOM   1769 N N    . GLY A  1 255 ? 125.005 149.868 109.723 1.00 72.97  ? 255 GLY U N    1 
ATOM   1770 C CA   . GLY A  1 255 ? 125.743 150.272 110.933 1.00 72.48  ? 255 GLY U CA   1 
ATOM   1771 C C    . GLY A  1 255 ? 125.084 149.721 112.184 1.00 71.96  ? 255 GLY U C    1 
ATOM   1772 O O    . GLY A  1 255 ? 125.410 148.581 112.575 1.00 76.31  ? 255 GLY U O    1 
ATOM   1773 N N    . LEU A  1 256 ? 124.182 150.503 112.778 1.00 71.48  ? 256 LEU U N    1 
ATOM   1774 C CA   . LEU A  1 256 ? 123.446 150.070 113.957 1.00 77.00  ? 256 LEU U CA   1 
ATOM   1775 C C    . LEU A  1 256 ? 122.720 148.747 113.749 1.00 83.49  ? 256 LEU U C    1 
ATOM   1776 O O    . LEU A  1 256 ? 122.312 148.118 114.729 1.00 87.67  ? 256 LEU U O    1 
ATOM   1777 C CB   . LEU A  1 256 ? 122.438 151.153 114.347 1.00 78.98  ? 256 LEU U CB   1 
ATOM   1778 C CG   . LEU A  1 256 ? 122.882 152.591 114.077 1.00 74.87  ? 256 LEU U CG   1 
ATOM   1779 C CD1  . LEU A  1 256 ? 121.721 153.553 114.254 1.00 76.77  ? 256 LEU U CD1  1 
ATOM   1780 C CD2  . LEU A  1 256 ? 124.042 152.978 114.977 1.00 84.26  ? 256 LEU U CD2  1 
ATOM   1781 N N    . TYR A  1 257 ? 122.542 148.312 112.502 1.00 71.24  ? 257 TYR U N    1 
ATOM   1782 C CA   . TYR A  1 257 ? 121.826 147.063 112.248 1.00 66.50  ? 257 TYR U CA   1 
ATOM   1783 C C    . TYR A  1 257 ? 122.565 145.872 112.851 1.00 74.24  ? 257 TYR U C    1 
ATOM   1784 O O    . TYR A  1 257 ? 121.957 145.014 113.508 1.00 79.26  ? 257 TYR U O    1 
ATOM   1785 C CB   . TYR A  1 257 ? 121.625 146.882 110.743 1.00 62.26  ? 257 TYR U CB   1 
ATOM   1786 C CG   . TYR A  1 257 ? 120.834 145.653 110.363 1.00 67.73  ? 257 TYR U CG   1 
ATOM   1787 C CD1  . TYR A  1 257 ? 119.475 145.573 110.617 1.00 72.13  ? 257 TYR U CD1  1 
ATOM   1788 C CD2  . TYR A  1 257 ? 121.443 144.578 109.734 1.00 72.29  ? 257 TYR U CD2  1 
ATOM   1789 C CE1  . TYR A  1 257 ? 118.749 144.451 110.269 1.00 68.05  ? 257 TYR U CE1  1 
ATOM   1790 C CE2  . TYR A  1 257 ? 120.727 143.458 109.380 1.00 69.01  ? 257 TYR U CE2  1 
ATOM   1791 C CZ   . TYR A  1 257 ? 119.380 143.399 109.651 1.00 67.80  ? 257 TYR U CZ   1 
ATOM   1792 O OH   . TYR A  1 257 ? 118.659 142.283 109.301 1.00 72.03  ? 257 TYR U OH   1 
ATOM   1793 N N    . ARG A  1 258 ? 123.883 145.807 112.655 1.00 67.22  ? 258 ARG U N    1 
ATOM   1794 C CA   . ARG A  1 258 ? 124.656 144.701 113.208 1.00 67.27  ? 258 ARG U CA   1 
ATOM   1795 C C    . ARG A  1 258 ? 124.681 144.750 114.732 1.00 77.23  ? 258 ARG U C    1 
ATOM   1796 O O    . ARG A  1 258 ? 124.591 143.709 115.399 1.00 85.17  ? 258 ARG U O    1 
ATOM   1797 C CB   . ARG A  1 258 ? 126.073 144.726 112.640 1.00 66.27  ? 258 ARG U CB   1 
ATOM   1798 C CG   . ARG A  1 258 ? 126.126 144.503 111.139 1.00 70.44  ? 258 ARG U CG   1 
ATOM   1799 C CD   . ARG A  1 258 ? 127.537 144.629 110.596 1.00 76.83  ? 258 ARG U CD   1 
ATOM   1800 N NE   . ARG A  1 258 ? 127.614 144.243 109.192 1.00 77.09  ? 258 ARG U NE   1 
ATOM   1801 C CZ   . ARG A  1 258 ? 128.698 144.362 108.441 1.00 73.81  ? 258 ARG U CZ   1 
ATOM   1802 N NH1  . ARG A  1 258 ? 129.818 144.875 108.922 1.00 74.24  ? 258 ARG U NH1  1 
ATOM   1803 N NH2  . ARG A  1 258 ? 128.656 143.964 107.174 1.00 70.54  ? 258 ARG U NH2  1 
ATOM   1804 N N    . PHE A  1 259 ? 124.796 145.950 115.301 1.00 65.72  ? 259 PHE U N    1 
ATOM   1805 C CA   . PHE A  1 259 ? 124.748 146.097 116.753 1.00 65.65  ? 259 PHE U CA   1 
ATOM   1806 C C    . PHE A  1 259 ? 123.416 145.607 117.313 1.00 69.33  ? 259 PHE U C    1 
ATOM   1807 O O    . PHE A  1 259 ? 123.377 144.897 118.325 1.00 74.20  ? 259 PHE U O    1 
ATOM   1808 C CB   . PHE A  1 259 ? 124.999 147.560 117.118 1.00 61.95  ? 259 PHE U CB   1 
ATOM   1809 C CG   . PHE A  1 259 ? 124.846 147.864 118.577 1.00 62.42  ? 259 PHE U CG   1 
ATOM   1810 C CD1  . PHE A  1 259 ? 125.763 147.390 119.497 1.00 66.95  ? 259 PHE U CD1  1 
ATOM   1811 C CD2  . PHE A  1 259 ? 123.801 148.649 119.028 1.00 63.43  ? 259 PHE U CD2  1 
ATOM   1812 C CE1  . PHE A  1 259 ? 125.627 147.675 120.838 1.00 66.79  ? 259 PHE U CE1  1 
ATOM   1813 C CE2  . PHE A  1 259 ? 123.661 148.938 120.367 1.00 65.21  ? 259 PHE U CE2  1 
ATOM   1814 C CZ   . PHE A  1 259 ? 124.576 148.451 121.272 1.00 64.89  ? 259 PHE U CZ   1 
ATOM   1815 N N    . ALA A  1 260 ? 122.315 145.969 116.653 1.00 63.09  ? 260 ALA U N    1 
ATOM   1816 C CA   . ALA A  1 260 ? 121.003 145.515 117.091 1.00 66.01  ? 260 ALA U CA   1 
ATOM   1817 C C    . ALA A  1 260 ? 120.886 144.001 116.990 1.00 69.56  ? 260 ALA U C    1 
ATOM   1818 O O    . ALA A  1 260 ? 120.324 143.353 117.882 1.00 79.86  ? 260 ALA U O    1 
ATOM   1819 C CB   . ALA A  1 260 ? 119.914 146.197 116.265 1.00 68.17  ? 260 ALA U CB   1 
ATOM   1820 N N    . ASN A  1 261 ? 121.404 143.418 115.909 1.00 64.17  ? 261 ASN U N    1 
ATOM   1821 C CA   . ASN A  1 261 ? 121.364 141.967 115.764 1.00 69.18  ? 261 ASN U CA   1 
ATOM   1822 C C    . ASN A  1 261 ? 122.110 141.292 116.908 1.00 70.31  ? 261 ASN U C    1 
ATOM   1823 O O    . ASN A  1 261 ? 121.614 140.330 117.518 1.00 72.82  ? 261 ASN U O    1 
ATOM   1824 C CB   . ASN A  1 261 ? 121.958 141.573 114.410 1.00 64.40  ? 261 ASN U CB   1 
ATOM   1825 C CG   . ASN A  1 261 ? 121.740 140.114 114.078 1.00 71.70  ? 261 ASN U CG   1 
ATOM   1826 O OD1  . ASN A  1 261 ? 120.783 139.498 114.541 1.00 79.49  ? 261 ASN U OD1  1 
ATOM   1827 N ND2  . ASN A  1 261 ? 122.625 139.555 113.262 1.00 67.88  ? 261 ASN U ND2  1 
ATOM   1828 N N    . PHE A  1 262 ? 123.301 141.801 117.229 1.00 65.81  ? 262 PHE U N    1 
ATOM   1829 C CA   . PHE A  1 262 ? 124.093 141.240 118.322 1.00 67.69  ? 262 PHE U CA   1 
ATOM   1830 C C    . PHE A  1 262 ? 123.343 141.319 119.644 1.00 73.16  ? 262 PHE U C    1 
ATOM   1831 O O    . PHE A  1 262 ? 123.241 140.326 120.381 1.00 75.96  ? 262 PHE U O    1 
ATOM   1832 C CB   . PHE A  1 262 ? 125.424 141.995 118.405 1.00 64.87  ? 262 PHE U CB   1 
ATOM   1833 C CG   . PHE A  1 262 ? 126.309 141.572 119.546 1.00 68.23  ? 262 PHE U CG   1 
ATOM   1834 C CD1  . PHE A  1 262 ? 127.142 140.476 119.428 1.00 72.79  ? 262 PHE U CD1  1 
ATOM   1835 C CD2  . PHE A  1 262 ? 126.319 142.288 120.729 1.00 71.43  ? 262 PHE U CD2  1 
ATOM   1836 C CE1  . PHE A  1 262 ? 127.958 140.096 120.472 1.00 73.19  ? 262 PHE U CE1  1 
ATOM   1837 C CE2  . PHE A  1 262 ? 127.135 141.909 121.776 1.00 70.67  ? 262 PHE U CE2  1 
ATOM   1838 C CZ   . PHE A  1 262 ? 127.956 140.813 121.646 1.00 68.35  ? 262 PHE U CZ   1 
ATOM   1839 N N    . VAL A  1 263 ? 122.773 142.485 119.945 1.00 67.69  ? 263 VAL U N    1 
ATOM   1840 C CA   . VAL A  1 263 ? 122.082 142.674 121.219 1.00 62.18  ? 263 VAL U CA   1 
ATOM   1841 C C    . VAL A  1 263 ? 120.888 141.733 121.325 1.00 62.70  ? 263 VAL U C    1 
ATOM   1842 O O    . VAL A  1 263 ? 120.680 141.066 122.351 1.00 72.76  ? 263 VAL U O    1 
ATOM   1843 C CB   . VAL A  1 263 ? 121.653 144.143 121.378 1.00 54.85  ? 263 VAL U CB   1 
ATOM   1844 C CG1  . VAL A  1 263 ? 120.735 144.301 122.572 1.00 64.32  ? 263 VAL U CG1  1 
ATOM   1845 C CG2  . VAL A  1 263 ? 122.872 145.036 121.514 1.00 57.85  ? 263 VAL U CG2  1 
ATOM   1846 N N    . PHE A  1 264 ? 120.081 141.666 120.261 1.00 59.23  ? 264 PHE U N    1 
ATOM   1847 C CA   . PHE A  1 264 ? 118.889 140.828 120.294 1.00 57.96  ? 264 PHE U CA   1 
ATOM   1848 C C    . PHE A  1 264 ? 119.247 139.364 120.481 1.00 59.14  ? 264 PHE U C    1 
ATOM   1849 O O    . PHE A  1 264 ? 118.634 138.665 121.299 1.00 70.50  ? 264 PHE U O    1 
ATOM   1850 C CB   . PHE A  1 264 ? 118.082 141.023 119.014 1.00 57.50  ? 264 PHE U CB   1 
ATOM   1851 C CG   . PHE A  1 264 ? 117.293 142.301 118.982 1.00 62.54  ? 264 PHE U CG   1 
ATOM   1852 C CD1  . PHE A  1 264 ? 116.723 142.805 120.133 1.00 65.31  ? 264 PHE U CD1  1 
ATOM   1853 C CD2  . PHE A  1 264 ? 117.130 142.997 117.801 1.00 61.21  ? 264 PHE U CD2  1 
ATOM   1854 C CE1  . PHE A  1 264 ? 116.000 143.981 120.106 1.00 64.58  ? 264 PHE U CE1  1 
ATOM   1855 C CE2  . PHE A  1 264 ? 116.408 144.172 117.768 1.00 61.61  ? 264 PHE U CE2  1 
ATOM   1856 C CZ   . PHE A  1 264 ? 115.844 144.663 118.920 1.00 60.55  ? 264 PHE U CZ   1 
ATOM   1857 N N    . ILE A  1 265 ? 120.248 138.877 119.742 1.00 60.26  ? 265 ILE U N    1 
ATOM   1858 C CA   . ILE A  1 265 ? 120.607 137.466 119.856 1.00 64.27  ? 265 ILE U CA   1 
ATOM   1859 C C    . ILE A  1 265 ? 121.103 137.154 121.262 1.00 66.48  ? 265 ILE U C    1 
ATOM   1860 O O    . ILE A  1 265 ? 120.729 136.136 121.859 1.00 69.90  ? 265 ILE U O    1 
ATOM   1861 C CB   . ILE A  1 265 ? 121.639 137.081 118.781 1.00 60.76  ? 265 ILE U CB   1 
ATOM   1862 C CG1  . ILE A  1 265 ? 121.014 137.197 117.393 1.00 60.47  ? 265 ILE U CG1  1 
ATOM   1863 C CG2  . ILE A  1 265 ? 122.141 135.670 119.013 1.00 60.16  ? 265 ILE U CG2  1 
ATOM   1864 C CD1  . ILE A  1 265 ? 121.924 136.762 116.271 1.00 63.35  ? 265 ILE U CD1  1 
ATOM   1865 N N    . LEU A  1 266 ? 121.941 138.030 121.823 1.00 61.69  ? 266 LEU U N    1 
ATOM   1866 C CA   . LEU A  1 266 ? 122.457 137.785 123.167 1.00 61.42  ? 266 LEU U CA   1 
ATOM   1867 C C    . LEU A  1 266 ? 121.329 137.704 124.190 1.00 67.01  ? 266 LEU U C    1 
ATOM   1868 O O    . LEU A  1 266 ? 121.253 136.751 124.985 1.00 72.89  ? 266 LEU U O    1 
ATOM   1869 C CB   . LEU A  1 266 ? 123.451 138.886 123.547 1.00 62.58  ? 266 LEU U CB   1 
ATOM   1870 C CG   . LEU A  1 266 ? 123.994 138.879 124.976 1.00 63.43  ? 266 LEU U CG   1 
ATOM   1871 C CD1  . LEU A  1 266 ? 124.722 137.584 125.267 1.00 61.59  ? 266 LEU U CD1  1 
ATOM   1872 C CD2  . LEU A  1 266 ? 124.913 140.068 125.191 1.00 63.55  ? 266 LEU U CD2  1 
ATOM   1873 N N    . MET A  1 267 ? 120.428 138.693 124.179 1.00 67.06  ? 267 MET U N    1 
ATOM   1874 C CA   . MET A  1 267 ? 119.350 138.704 125.166 1.00 64.00  ? 267 MET U CA   1 
ATOM   1875 C C    . MET A  1 267 ? 118.449 137.486 125.016 1.00 69.99  ? 267 MET U C    1 
ATOM   1876 O O    . MET A  1 267 ? 118.066 136.856 126.016 1.00 83.12  ? 267 MET U O    1 
ATOM   1877 C CB   . MET A  1 267 ? 118.544 139.995 125.041 1.00 67.29  ? 267 MET U CB   1 
ATOM   1878 C CG   . MET A  1 267 ? 119.394 141.254 125.082 1.00 75.87  ? 267 MET U CG   1 
ATOM   1879 S SD   . MET A  1 267 ? 118.460 142.729 125.531 1.00 102.51 ? 267 MET U SD   1 
ATOM   1880 C CE   . MET A  1 267 ? 116.968 142.497 124.571 1.00 74.31  ? 267 MET U CE   1 
ATOM   1881 N N    . GLY A  1 268 ? 118.100 137.131 123.778 1.00 61.15  ? 268 GLY U N    1 
ATOM   1882 C CA   . GLY A  1 268 ? 117.244 135.975 123.572 1.00 60.47  ? 268 GLY U CA   1 
ATOM   1883 C C    . GLY A  1 268 ? 117.874 134.689 124.062 1.00 59.80  ? 268 GLY U C    1 
ATOM   1884 O O    . GLY A  1 268 ? 117.208 133.862 124.699 1.00 61.20  ? 268 GLY U O    1 
ATOM   1885 N N    . VAL A  1 269 ? 119.164 134.496 123.783 1.00 61.42  ? 269 VAL U N    1 
ATOM   1886 C CA   . VAL A  1 269 ? 119.832 133.278 124.225 1.00 61.15  ? 269 VAL U CA   1 
ATOM   1887 C C    . VAL A  1 269 ? 119.836 133.191 125.744 1.00 65.73  ? 269 VAL U C    1 
ATOM   1888 O O    . VAL A  1 269 ? 119.544 132.134 126.323 1.00 75.72  ? 269 VAL U O    1 
ATOM   1889 C CB   . VAL A  1 269 ? 121.259 133.206 123.654 1.00 60.75  ? 269 VAL U CB   1 
ATOM   1890 C CG1  . VAL A  1 269 ? 122.027 132.074 124.308 1.00 63.94  ? 269 VAL U CG1  1 
ATOM   1891 C CG2  . VAL A  1 269 ? 121.218 133.021 122.150 1.00 63.11  ? 269 VAL U CG2  1 
ATOM   1892 N N    . CYS A  1 270 ? 120.149 134.303 126.418 1.00 66.21  ? 270 CYS U N    1 
ATOM   1893 C CA   . CYS A  1 270 ? 120.151 134.280 127.879 1.00 64.59  ? 270 CYS U CA   1 
ATOM   1894 C C    . CYS A  1 270 ? 118.780 133.891 128.425 1.00 69.89  ? 270 CYS U C    1 
ATOM   1895 O O    . CYS A  1 270 ? 118.662 132.996 129.282 1.00 76.32  ? 270 CYS U O    1 
ATOM   1896 C CB   . CYS A  1 270 ? 120.583 135.639 128.423 1.00 63.46  ? 270 CYS U CB   1 
ATOM   1897 S SG   . CYS A  1 270 ? 122.312 136.053 128.118 1.00 86.84  ? 270 CYS U SG   1 
ATOM   1898 N N    . CYS A  1 271 ? 117.724 134.542 127.924 1.00 68.92  ? 271 CYS U N    1 
ATOM   1899 C CA   . CYS A  1 271 ? 116.389 134.267 128.453 1.00 62.71  ? 271 CYS U CA   1 
ATOM   1900 C C    . CYS A  1 271 ? 115.971 132.822 128.209 1.00 70.23  ? 271 CYS U C    1 
ATOM   1901 O O    . CYS A  1 271 ? 115.420 132.165 129.106 1.00 78.45  ? 271 CYS U O    1 
ATOM   1902 C CB   . CYS A  1 271 ? 115.376 135.230 127.839 1.00 65.14  ? 271 CYS U CB   1 
ATOM   1903 S SG   . CYS A  1 271 ? 115.569 136.945 128.368 1.00 91.63  ? 271 CYS U SG   1 
ATOM   1904 N N    . ILE A  1 272 ? 116.235 132.298 127.010 1.00 64.59  ? 272 ILE U N    1 
ATOM   1905 C CA   . ILE A  1 272 ? 115.799 130.938 126.703 1.00 61.01  ? 272 ILE U CA   1 
ATOM   1906 C C    . ILE A  1 272 ? 116.555 129.916 127.544 1.00 65.26  ? 272 ILE U C    1 
ATOM   1907 O O    . ILE A  1 272 ? 115.977 128.930 128.014 1.00 68.34  ? 272 ILE U O    1 
ATOM   1908 C CB   . ILE A  1 272 ? 115.937 130.653 125.198 1.00 61.44  ? 272 ILE U CB   1 
ATOM   1909 C CG1  . ILE A  1 272 ? 114.876 131.432 124.421 1.00 63.85  ? 272 ILE U CG1  1 
ATOM   1910 C CG2  . ILE A  1 272 ? 115.790 129.172 124.931 1.00 65.13  ? 272 ILE U CG2  1 
ATOM   1911 C CD1  . ILE A  1 272 ? 113.471 130.971 124.698 1.00 55.16  ? 272 ILE U CD1  1 
ATOM   1912 N N    . TYR A  1 273 ? 117.860 130.123 127.742 1.00 70.90  ? 273 TYR U N    1 
ATOM   1913 C CA   . TYR A  1 273 ? 118.613 129.182 128.574 1.00 70.51  ? 273 TYR U CA   1 
ATOM   1914 C C    . TYR A  1 273 ? 118.092 129.183 130.008 1.00 73.92  ? 273 TYR U C    1 
ATOM   1915 O O    . TYR A  1 273 ? 117.942 128.118 130.629 1.00 79.91  ? 273 TYR U O    1 
ATOM   1916 C CB   . TYR A  1 273 ? 120.100 129.524 128.531 1.00 70.71  ? 273 TYR U CB   1 
ATOM   1917 C CG   . TYR A  1 273 ? 121.002 128.316 128.596 1.00 79.94  ? 273 TYR U CG   1 
ATOM   1918 C CD1  . TYR A  1 273 ? 121.102 127.445 127.519 1.00 75.62  ? 273 TYR U CD1  1 
ATOM   1919 C CD2  . TYR A  1 273 ? 121.763 128.050 129.723 1.00 79.43  ? 273 TYR U CD2  1 
ATOM   1920 C CE1  . TYR A  1 273 ? 121.925 126.340 127.571 1.00 77.09  ? 273 TYR U CE1  1 
ATOM   1921 C CE2  . TYR A  1 273 ? 122.591 126.949 129.784 1.00 79.94  ? 273 TYR U CE2  1 
ATOM   1922 C CZ   . TYR A  1 273 ? 122.669 126.096 128.704 1.00 81.26  ? 273 TYR U CZ   1 
ATOM   1923 O OH   . TYR A  1 273 ? 123.490 124.996 128.758 1.00 81.39  ? 273 TYR U OH   1 
ATOM   1924 N N    . SER A  1 274 ? 117.795 130.368 130.551 1.00 67.77  ? 274 SER U N    1 
ATOM   1925 C CA   . SER A  1 274 ? 117.228 130.421 131.895 1.00 66.63  ? 274 SER U CA   1 
ATOM   1926 C C    . SER A  1 274 ? 115.894 129.681 131.965 1.00 68.72  ? 274 SER U C    1 
ATOM   1927 O O    . SER A  1 274 ? 115.630 128.939 132.927 1.00 76.95  ? 274 SER U O    1 
ATOM   1928 C CB   . SER A  1 274 ? 117.066 131.872 132.338 1.00 72.95  ? 274 SER U CB   1 
ATOM   1929 O OG   . SER A  1 274 ? 118.312 132.543 132.324 1.00 73.03  ? 274 SER U OG   1 
ATOM   1930 N N    . LEU A  1 275 ? 115.047 129.867 130.951 1.00 60.45  ? 275 LEU U N    1 
ATOM   1931 C CA   . LEU A  1 275 ? 113.762 129.170 130.939 1.00 63.01  ? 275 LEU U CA   1 
ATOM   1932 C C    . LEU A  1 275 ? 113.956 127.659 130.914 1.00 68.84  ? 275 LEU U C    1 
ATOM   1933 O O    . LEU A  1 275 ? 113.238 126.922 131.607 1.00 74.29  ? 275 LEU U O    1 
ATOM   1934 C CB   . LEU A  1 275 ? 112.929 129.623 129.743 1.00 57.31  ? 275 LEU U CB   1 
ATOM   1935 C CG   . LEU A  1 275 ? 111.553 128.972 129.625 1.00 57.03  ? 275 LEU U CG   1 
ATOM   1936 C CD1  . LEU A  1 275 ? 110.735 129.233 130.875 1.00 58.04  ? 275 LEU U CD1  1 
ATOM   1937 C CD2  . LEU A  1 275 ? 110.828 129.475 128.392 1.00 61.42  ? 275 LEU U CD2  1 
ATOM   1938 N N    . PHE A  1 276 ? 114.914 127.177 130.119 1.00 61.47  ? 276 PHE U N    1 
ATOM   1939 C CA   . PHE A  1 276 ? 115.161 125.740 130.072 1.00 51.39  ? 276 PHE U CA   1 
ATOM   1940 C C    . PHE A  1 276 ? 115.586 125.206 131.435 1.00 54.91  ? 276 PHE U C    1 
ATOM   1941 O O    . PHE A  1 276 ? 115.116 124.149 131.870 1.00 65.90  ? 276 PHE U O    1 
ATOM   1942 C CB   . PHE A  1 276 ? 116.217 125.414 129.018 1.00 52.74  ? 276 PHE U CB   1 
ATOM   1943 C CG   . PHE A  1 276 ? 115.696 125.420 127.608 1.00 62.92  ? 276 PHE U CG   1 
ATOM   1944 C CD1  . PHE A  1 276 ? 114.345 125.555 127.354 1.00 62.57  ? 276 PHE U CD1  1 
ATOM   1945 C CD2  . PHE A  1 276 ? 116.561 125.282 126.537 1.00 59.89  ? 276 PHE U CD2  1 
ATOM   1946 C CE1  . PHE A  1 276 ? 113.867 125.557 126.058 1.00 60.86  ? 276 PHE U CE1  1 
ATOM   1947 C CE2  . PHE A  1 276 ? 116.087 125.284 125.243 1.00 55.77  ? 276 PHE U CE2  1 
ATOM   1948 C CZ   . PHE A  1 276 ? 114.739 125.420 125.005 1.00 55.26  ? 276 PHE U CZ   1 
ATOM   1949 N N    . ASN A  1 277 ? 116.468 125.930 132.130 1.00 61.23  ? 277 ASN U N    1 
ATOM   1950 C CA   . ASN A  1 277 ? 116.894 125.464 133.447 1.00 62.08  ? 277 ASN U CA   1 
ATOM   1951 C C    . ASN A  1 277 ? 115.725 125.400 134.430 1.00 64.28  ? 277 ASN U C    1 
ATOM   1952 O O    . ASN A  1 277 ? 115.583 124.425 135.189 1.00 70.35  ? 277 ASN U O    1 
ATOM   1953 C CB   . ASN A  1 277 ? 118.005 126.361 133.988 1.00 62.99  ? 277 ASN U CB   1 
ATOM   1954 C CG   . ASN A  1 277 ? 119.335 126.114 133.308 1.00 70.76  ? 277 ASN U CG   1 
ATOM   1955 O OD1  . ASN A  1 277 ? 120.087 125.223 133.697 1.00 74.67  ? 277 ASN U OD1  1 
ATOM   1956 N ND2  . ASN A  1 277 ? 119.631 126.901 132.283 1.00 69.03  ? 277 ASN U ND2  1 
ATOM   1957 N N    . VAL A  1 278 ? 114.863 126.423 134.425 1.00 62.81  ? 278 VAL U N    1 
ATOM   1958 C CA   . VAL A  1 278 ? 113.724 126.415 135.339 1.00 61.34  ? 278 VAL U CA   1 
ATOM   1959 C C    . VAL A  1 278 ? 112.787 125.249 135.029 1.00 68.04  ? 278 VAL U C    1 
ATOM   1960 O O    . VAL A  1 278 ? 112.296 124.555 135.938 1.00 71.05  ? 278 VAL U O    1 
ATOM   1961 C CB   . VAL A  1 278 ? 112.992 127.767 135.294 1.00 64.47  ? 278 VAL U CB   1 
ATOM   1962 C CG1  . VAL A  1 278 ? 111.708 127.696 136.093 1.00 66.86  ? 278 VAL U CG1  1 
ATOM   1963 C CG2  . VAL A  1 278 ? 113.890 128.866 135.828 1.00 61.56  ? 278 VAL U CG2  1 
ATOM   1964 N N    . ILE A  1 279 ? 112.516 125.016 133.743 1.00 64.53  ? 279 ILE U N    1 
ATOM   1965 C CA   . ILE A  1 279 ? 111.653 123.903 133.365 1.00 59.33  ? 279 ILE U CA   1 
ATOM   1966 C C    . ILE A  1 279 ? 112.259 122.581 133.817 1.00 63.39  ? 279 ILE U C    1 
ATOM   1967 O O    . ILE A  1 279 ? 111.542 121.665 134.241 1.00 65.79  ? 279 ILE U O    1 
ATOM   1968 C CB   . ILE A  1 279 ? 111.393 123.912 131.848 1.00 58.73  ? 279 ILE U CB   1 
ATOM   1969 C CG1  . ILE A  1 279 ? 110.663 125.187 131.434 1.00 56.18  ? 279 ILE U CG1  1 
ATOM   1970 C CG2  . ILE A  1 279 ? 110.590 122.694 131.444 1.00 62.62  ? 279 ILE U CG2  1 
ATOM   1971 C CD1  . ILE A  1 279 ? 109.219 125.218 131.858 1.00 62.61  ? 279 ILE U CD1  1 
ATOM   1972 N N    . SER A  1 280 ? 113.584 122.457 133.725 1.00 61.70  ? 280 SER U N    1 
ATOM   1973 C CA   . SER A  1 280 ? 114.235 121.230 134.173 1.00 55.07  ? 280 SER U CA   1 
ATOM   1974 C C    . SER A  1 280 ? 114.032 121.014 135.666 1.00 59.20  ? 280 SER U C    1 
ATOM   1975 O O    . SER A  1 280 ? 113.775 119.888 136.113 1.00 65.53  ? 280 SER U O    1 
ATOM   1976 C CB   . SER A  1 280 ? 115.721 121.272 133.837 1.00 60.01  ? 280 SER U CB   1 
ATOM   1977 O OG   . SER A  1 280 ? 116.477 120.588 134.815 1.00 72.94  ? 280 SER U OG   1 
ATOM   1978 N N    . ILE A  1 281 ? 114.141 122.081 136.456 1.00 67.63  ? 281 ILE U N    1 
ATOM   1979 C CA   . ILE A  1 281 ? 113.906 121.951 137.898 1.00 63.93  ? 281 ILE U CA   1 
ATOM   1980 C C    . ILE A  1 281 ? 112.487 121.459 138.162 1.00 66.98  ? 281 ILE U C    1 
ATOM   1981 O O    . ILE A  1 281 ? 112.255 120.557 138.984 1.00 71.62  ? 281 ILE U O    1 
ATOM   1982 C CB   . ILE A  1 281 ? 114.180 123.287 138.611 1.00 62.22  ? 281 ILE U CB   1 
ATOM   1983 C CG1  . ILE A  1 281 ? 115.672 123.622 138.560 1.00 65.85  ? 281 ILE U CG1  1 
ATOM   1984 C CG2  . ILE A  1 281 ? 113.695 123.225 140.045 1.00 61.80  ? 281 ILE U CG2  1 
ATOM   1985 C CD1  . ILE A  1 281 ? 116.025 124.902 139.276 1.00 70.54  ? 281 ILE U CD1  1 
ATOM   1986 N N    . LEU A  1 282 ? 111.509 122.045 137.466 1.00 71.46  ? 282 LEU U N    1 
ATOM   1987 C CA   . LEU A  1 282 ? 110.126 121.618 137.671 1.00 65.10  ? 282 LEU U CA   1 
ATOM   1988 C C    . LEU A  1 282 ? 109.929 120.152 137.289 1.00 67.14  ? 282 LEU U C    1 
ATOM   1989 O O    . LEU A  1 282 ? 109.231 119.409 137.990 1.00 69.43  ? 282 LEU U O    1 
ATOM   1990 C CB   . LEU A  1 282 ? 109.178 122.510 136.871 1.00 67.95  ? 282 LEU U CB   1 
ATOM   1991 C CG   . LEU A  1 282 ? 108.864 123.874 137.486 1.00 70.88  ? 282 LEU U CG   1 
ATOM   1992 C CD1  . LEU A  1 282 ? 107.842 124.614 136.643 1.00 72.95  ? 282 LEU U CD1  1 
ATOM   1993 C CD2  . LEU A  1 282 ? 108.363 123.707 138.908 1.00 65.88  ? 282 LEU U CD2  1 
ATOM   1994 N N    . ILE A  1 283 ? 110.537 119.722 136.182 1.00 66.57  ? 283 ILE U N    1 
ATOM   1995 C CA   . ILE A  1 283 ? 110.396 118.329 135.760 1.00 63.22  ? 283 ILE U CA   1 
ATOM   1996 C C    . ILE A  1 283 ? 111.001 117.391 136.793 1.00 64.80  ? 283 ILE U C    1 
ATOM   1997 O O    . ILE A  1 283 ? 110.465 116.311 137.064 1.00 63.46  ? 283 ILE U O    1 
ATOM   1998 C CB   . ILE A  1 283 ? 111.028 118.120 134.371 1.00 56.86  ? 283 ILE U CB   1 
ATOM   1999 C CG1  . ILE A  1 283 ? 110.233 118.874 133.305 1.00 59.29  ? 283 ILE U CG1  1 
ATOM   2000 C CG2  . ILE A  1 283 ? 111.087 116.643 134.036 1.00 52.66  ? 283 ILE U CG2  1 
ATOM   2001 C CD1  . ILE A  1 283 ? 110.774 118.693 131.909 1.00 59.40  ? 283 ILE U CD1  1 
ATOM   2002 N N    . LYS A  1 284 ? 112.136 117.780 137.381 1.00 70.86  ? 284 LYS U N    1 
ATOM   2003 C CA   . LYS A  1 284 ? 112.738 116.943 138.416 1.00 65.41  ? 284 LYS U CA   1 
ATOM   2004 C C    . LYS A  1 284 ? 111.822 116.812 139.622 1.00 64.43  ? 284 LYS U C    1 
ATOM   2005 O O    . LYS A  1 284 ? 111.667 115.715 140.184 1.00 64.48  ? 284 LYS U O    1 
ATOM   2006 C CB   . LYS A  1 284 ? 114.088 117.519 138.839 1.00 67.33  ? 284 LYS U CB   1 
ATOM   2007 C CG   . LYS A  1 284 ? 114.614 116.947 140.141 1.00 62.46  ? 284 LYS U CG   1 
ATOM   2008 C CD   . LYS A  1 284 ? 116.126 117.019 140.203 1.00 65.37  ? 284 LYS U CD   1 
ATOM   2009 C CE   . LYS A  1 284 ? 116.667 116.177 141.345 1.00 66.15  ? 284 LYS U CE   1 
ATOM   2010 N NZ   . LYS A  1 284 ? 118.152 116.214 141.404 1.00 73.58  ? 284 LYS U NZ   1 
ATOM   2011 N N    . GLN A  1 285 ? 111.195 117.913 140.039 1.00 79.13  ? 285 GLN U N    1 
ATOM   2012 C CA   . GLN A  1 285 ? 110.261 117.826 141.159 1.00 73.71  ? 285 GLN U CA   1 
ATOM   2013 C C    . GLN A  1 285 ? 109.089 116.911 140.826 1.00 73.45  ? 285 GLN U C    1 
ATOM   2014 O O    . GLN A  1 285 ? 108.646 116.118 141.672 1.00 76.65  ? 285 GLN U O    1 
ATOM   2015 C CB   . GLN A  1 285 ? 109.762 119.219 141.541 1.00 75.66  ? 285 GLN U CB   1 
ATOM   2016 C CG   . GLN A  1 285 ? 110.581 119.887 142.629 1.00 78.61  ? 285 GLN U CG   1 
ATOM   2017 C CD   . GLN A  1 285 ? 110.105 121.292 142.929 1.00 86.38  ? 285 GLN U CD   1 
ATOM   2018 O OE1  . GLN A  1 285 ? 108.953 121.636 142.673 1.00 89.29  ? 285 GLN U OE1  1 
ATOM   2019 N NE2  . GLN A  1 285 ? 110.998 122.113 143.469 1.00 87.02  ? 285 GLN U NE2  1 
ATOM   2020 N N    . SER A  1 286 ? 108.574 116.999 139.599 1.00 74.63  ? 286 SER U N    1 
ATOM   2021 C CA   . SER A  1 286 ? 107.470 116.127 139.202 1.00 72.74  ? 286 SER U CA   1 
ATOM   2022 C C    . SER A  1 286 ? 107.881 114.658 139.219 1.00 77.86  ? 286 SER U C    1 
ATOM   2023 O O    . SER A  1 286 ? 107.104 113.791 139.643 1.00 77.11  ? 286 SER U O    1 
ATOM   2024 C CB   . SER A  1 286 ? 106.962 116.522 137.817 1.00 77.01  ? 286 SER U CB   1 
ATOM   2025 O OG   . SER A  1 286 ? 106.489 115.393 137.114 1.00 86.21  ? 286 SER U OG   1 
ATOM   2026 N N    . LEU A  1 287 ? 109.093 114.355 138.745 1.00 80.55  ? 287 LEU U N    1 
ATOM   2027 C CA   . LEU A  1 287 ? 109.570 112.973 138.793 1.00 67.23  ? 287 LEU U CA   1 
ATOM   2028 C C    . LEU A  1 287 ? 109.675 112.480 140.227 1.00 69.04  ? 287 LEU U C    1 
ATOM   2029 O O    . LEU A  1 287 ? 109.303 111.340 140.532 1.00 68.69  ? 287 LEU U O    1 
ATOM   2030 C CB   . LEU A  1 287 ? 110.923 112.849 138.096 1.00 65.75  ? 287 LEU U CB   1 
ATOM   2031 C CG   . LEU A  1 287 ? 110.942 112.772 136.572 1.00 70.27  ? 287 LEU U CG   1 
ATOM   2032 C CD1  . LEU A  1 287 ? 112.351 112.502 136.086 1.00 70.84  ? 287 LEU U CD1  1 
ATOM   2033 C CD2  . LEU A  1 287 ? 109.990 111.698 136.084 1.00 72.30  ? 287 LEU U CD2  1 
ATOM   2034 N N    . ASN A  1 288 ? 110.178 113.330 141.128 1.00 85.52  ? 288 ASN U N    1 
ATOM   2035 C CA   . ASN A  1 288 ? 110.236 112.950 142.536 1.00 82.14  ? 288 ASN U CA   1 
ATOM   2036 C C    . ASN A  1 288 ? 108.850 112.621 143.067 1.00 80.51  ? 288 ASN U C    1 
ATOM   2037 O O    . ASN A  1 288 ? 108.666 111.620 143.769 1.00 81.01  ? 288 ASN U O    1 
ATOM   2038 C CB   . ASN A  1 288 ? 110.876 114.063 143.364 1.00 83.20  ? 288 ASN U CB   1 
ATOM   2039 C CG   . ASN A  1 288 ? 112.360 113.859 143.566 1.00 83.65  ? 288 ASN U CG   1 
ATOM   2040 O OD1  . ASN A  1 288 ? 112.848 112.729 143.582 1.00 83.95  ? 288 ASN U OD1  1 
ATOM   2041 N ND2  . ASN A  1 288 ? 113.091 114.955 143.730 1.00 84.00  ? 288 ASN U ND2  1 
ATOM   2042 N N    . TRP A  1 289 ? 107.860 113.448 142.737 1.00 94.40  ? 289 TRP U N    1 
ATOM   2043 C CA   . TRP A  1 289 ? 106.508 113.188 143.220 1.00 95.08  ? 289 TRP U CA   1 
ATOM   2044 C C    . TRP A  1 289 ? 105.982 111.861 142.692 1.00 93.93  ? 289 TRP U C    1 
ATOM   2045 O O    . TRP A  1 289 ? 105.425 111.055 143.446 1.00 94.01  ? 289 TRP U O    1 
ATOM   2046 C CB   . TRP A  1 289 ? 105.557 114.319 142.824 1.00 99.65  ? 289 TRP U CB   1 
ATOM   2047 C CG   . TRP A  1 289 ? 104.137 114.017 143.204 1.00 101.01 ? 289 TRP U CG   1 
ATOM   2048 C CD1  . TRP A  1 289 ? 103.565 114.184 144.432 1.00 97.93  ? 289 TRP U CD1  1 
ATOM   2049 C CD2  . TRP A  1 289 ? 103.116 113.474 142.358 1.00 100.16 ? 289 TRP U CD2  1 
ATOM   2050 N NE1  . TRP A  1 289 ? 102.251 113.787 144.402 1.00 96.39  ? 289 TRP U NE1  1 
ATOM   2051 C CE2  . TRP A  1 289 ? 101.949 113.347 143.140 1.00 97.36  ? 289 TRP U CE2  1 
ATOM   2052 C CE3  . TRP A  1 289 ? 103.070 113.088 141.016 1.00 96.99  ? 289 TRP U CE3  1 
ATOM   2053 C CZ2  . TRP A  1 289 ? 100.755 112.853 142.623 1.00 94.31  ? 289 TRP U CZ2  1 
ATOM   2054 C CZ3  . TRP A  1 289 ? 101.884 112.596 140.507 1.00 95.54  ? 289 TRP U CZ3  1 
ATOM   2055 C CH2  . TRP A  1 289 ? 100.745 112.482 141.307 1.00 93.42  ? 289 TRP U CH2  1 
ATOM   2056 N N    . ILE A  1 290 ? 106.134 111.620 141.389 1.00 93.23  ? 290 ILE U N    1 
ATOM   2057 C CA   . ILE A  1 290 ? 105.558 110.409 140.812 1.00 89.45  ? 290 ILE U CA   1 
ATOM   2058 C C    . ILE A  1 290 ? 106.263 109.167 141.339 1.00 87.87  ? 290 ILE U C    1 
ATOM   2059 O O    . ILE A  1 290 ? 105.632 108.114 141.522 1.00 84.84  ? 290 ILE U O    1 
ATOM   2060 C CB   . ILE A  1 290 ? 105.606 110.468 139.275 1.00 88.19  ? 290 ILE U CB   1 
ATOM   2061 C CG1  . ILE A  1 290 ? 105.248 109.106 138.678 1.00 86.69  ? 290 ILE U CG1  1 
ATOM   2062 C CG2  . ILE A  1 290 ? 106.974 110.915 138.801 1.00 88.62  ? 290 ILE U CG2  1 
ATOM   2063 C CD1  . ILE A  1 290 ? 105.324 109.069 137.172 1.00 88.57  ? 290 ILE U CD1  1 
ATOM   2064 N N    . LEU A  1 291 ? 107.551 109.272 141.662 1.00 100.12 ? 291 LEU U N    1 
ATOM   2065 C CA   . LEU A  1 291 ? 108.242 108.098 142.177 1.00 97.10  ? 291 LEU U CA   1 
ATOM   2066 C C    . LEU A  1 291 ? 107.909 107.867 143.642 1.00 100.33 ? 291 LEU U C    1 
ATOM   2067 O O    . LEU A  1 291 ? 107.867 106.715 144.089 1.00 98.91  ? 291 LEU U O    1 
ATOM   2068 C CB   . LEU A  1 291 ? 109.751 108.248 141.989 1.00 93.93  ? 291 LEU U CB   1 
ATOM   2069 C CG   . LEU A  1 291 ? 110.579 106.977 142.135 1.00 94.44  ? 291 LEU U CG   1 
ATOM   2070 C CD1  . LEU A  1 291 ? 110.230 105.990 141.040 1.00 98.19  ? 291 LEU U CD1  1 
ATOM   2071 C CD2  . LEU A  1 291 ? 112.054 107.320 142.092 1.00 95.85  ? 291 LEU U CD2  1 
ATOM   2072 N N    . ARG A  1 292 ? 107.679 108.939 144.406 1.00 123.18 ? 292 ARG U N    1 
ATOM   2073 C CA   . ARG A  1 292 ? 107.177 108.763 145.763 1.00 121.98 ? 292 ARG U CA   1 
ATOM   2074 C C    . ARG A  1 292 ? 105.805 108.107 145.733 1.00 121.26 ? 292 ARG U C    1 
ATOM   2075 O O    . ARG A  1 292 ? 105.496 107.246 146.566 1.00 118.85 ? 292 ARG U O    1 
ATOM   2076 C CB   . ARG A  1 292 ? 107.115 110.115 146.473 1.00 120.52 ? 292 ARG U CB   1 
ATOM   2077 C CG   . ARG A  1 292 ? 106.671 110.055 147.920 1.00 119.59 ? 292 ARG U CG   1 
ATOM   2078 C CD   . ARG A  1 292 ? 106.449 111.457 148.457 1.00 120.67 ? 292 ARG U CD   1 
ATOM   2079 N NE   . ARG A  1 292 ? 107.570 112.335 148.142 1.00 123.10 ? 292 ARG U NE   1 
ATOM   2080 C CZ   . ARG A  1 292 ? 107.570 113.647 148.328 1.00 123.91 ? 292 ARG U CZ   1 
ATOM   2081 N NH1  . ARG A  1 292 ? 106.520 114.274 148.827 1.00 123.50 ? 292 ARG U NH1  1 
ATOM   2082 N NH2  . ARG A  1 292 ? 108.652 114.349 148.001 1.00 123.09 ? 292 ARG U NH2  1 
ATOM   2083 N N    . LYS A  1 293 ? 104.968 108.504 144.768 1.00 128.58 ? 293 LYS U N    1 
ATOM   2084 C CA   . LYS A  1 293 ? 103.629 107.932 144.652 1.00 126.60 ? 293 LYS U CA   1 
ATOM   2085 C C    . LYS A  1 293 ? 103.689 106.456 144.291 1.00 125.88 ? 293 LYS U C    1 
ATOM   2086 O O    . LYS A  1 293 ? 102.875 105.662 144.775 1.00 126.36 ? 293 LYS U O    1 
ATOM   2087 C CB   . LYS A  1 293 ? 102.820 108.705 143.610 1.00 127.89 ? 293 LYS U CB   1 
ATOM   2088 C CG   . LYS A  1 293 ? 101.431 108.140 143.377 1.00 126.93 ? 293 LYS U CG   1 
ATOM   2089 C CD   . LYS A  1 293 ? 100.613 108.157 144.653 1.00 126.97 ? 293 LYS U CD   1 
ATOM   2090 C CE   . LYS A  1 293 ? 100.350 109.579 145.113 1.00 127.83 ? 293 LYS U CE   1 
ATOM   2091 N NZ   . LYS A  1 293 ? 99.548  110.341 144.121 1.00 128.17 ? 293 LYS U NZ   1 
ATOM   2092 N N    . MET A  1 294 ? 104.642 106.067 143.441 1.00 131.53 ? 294 MET U N    1 
ATOM   2093 C CA   . MET A  1 294 ? 104.712 104.671 143.023 1.00 131.90 ? 294 MET U CA   1 
ATOM   2094 C C    . MET A  1 294 ? 105.009 103.733 144.188 1.00 133.27 ? 294 MET U C    1 
ATOM   2095 O O    . MET A  1 294 ? 104.765 102.527 144.074 1.00 131.73 ? 294 MET U O    1 
ATOM   2096 C CB   . MET A  1 294 ? 105.771 104.496 141.934 1.00 131.54 ? 294 MET U CB   1 
ATOM   2097 C CG   . MET A  1 294 ? 105.710 103.154 141.224 1.00 131.92 ? 294 MET U CG   1 
ATOM   2098 S SD   . MET A  1 294 ? 106.983 102.970 139.961 1.00 138.97 ? 294 MET U SD   1 
ATOM   2099 C CE   . MET A  1 294 ? 106.619 104.374 138.915 1.00 131.39 ? 294 MET U CE   1 
ATOM   2100 N N    . ASP A  1 295 ? 105.524 104.256 145.296 1.00 139.85 ? 295 ASP U N    1 
ATOM   2101 C CA   . ASP A  1 295 ? 105.838 103.434 146.460 1.00 138.81 ? 295 ASP U CA   1 
ATOM   2102 C C    . ASP A  1 295 ? 106.837 102.335 146.112 1.00 140.45 ? 295 ASP U C    1 
ATOM   2103 O O    . ASP A  1 295 ? 107.669 101.959 146.939 1.00 140.92 ? 295 ASP U O    1 
ATOM   2104 C CB   . ASP A  1 295 ? 104.566 102.817 147.043 1.00 138.68 ? 295 ASP U CB   1 
ATOM   2105 C CG   . ASP A  1 295 ? 103.574 103.863 147.513 1.00 141.07 ? 295 ASP U CG   1 
ATOM   2106 O OD1  . ASP A  1 295 ? 103.904 105.066 147.452 1.00 141.58 ? 295 ASP U OD1  1 
ATOM   2107 O OD2  . ASP A  1 295 ? 102.467 103.482 147.947 1.00 141.52 ? 295 ASP U OD2  1 
ATOM   2108 N N    . ASN B  1 14  ? 128.415 143.728 146.042 1.00 91.96  ? 14  ASN A N    1 
ATOM   2109 C CA   . ASN B  1 14  ? 129.278 144.500 145.159 1.00 95.40  ? 14  ASN A CA   1 
ATOM   2110 C C    . ASN B  1 14  ? 130.316 143.598 144.501 1.00 97.32  ? 14  ASN A C    1 
ATOM   2111 O O    . ASN B  1 14  ? 130.830 143.908 143.428 1.00 103.77 ? 14  ASN A O    1 
ATOM   2112 C CB   . ASN B  1 14  ? 129.967 145.627 145.929 1.00 98.28  ? 14  ASN A CB   1 
ATOM   2113 C CG   . ASN B  1 14  ? 130.673 146.612 145.017 1.00 98.63  ? 14  ASN A CG   1 
ATOM   2114 O OD1  . ASN B  1 14  ? 130.338 146.734 143.839 1.00 98.21  ? 14  ASN A OD1  1 
ATOM   2115 N ND2  . ASN B  1 14  ? 131.649 147.327 145.564 1.00 96.77  ? 14  ASN A ND2  1 
ATOM   2116 N N    . GLU B  1 15  ? 130.626 142.481 145.159 1.00 96.89  ? 15  GLU A N    1 
ATOM   2117 C CA   . GLU B  1 15  ? 131.572 141.527 144.591 1.00 99.50  ? 15  GLU A CA   1 
ATOM   2118 C C    . GLU B  1 15  ? 131.004 140.864 143.341 1.00 103.10 ? 15  GLU A C    1 
ATOM   2119 O O    . GLU B  1 15  ? 131.717 140.682 142.345 1.00 107.07 ? 15  GLU A O    1 
ATOM   2120 C CB   . GLU B  1 15  ? 131.938 140.476 145.636 1.00 97.72  ? 15  GLU A CB   1 
ATOM   2121 C CG   . GLU B  1 15  ? 132.942 139.444 145.169 1.00 100.88 ? 15  GLU A CG   1 
ATOM   2122 C CD   . GLU B  1 15  ? 133.258 138.418 146.241 1.00 105.40 ? 15  GLU A CD   1 
ATOM   2123 O OE1  . GLU B  1 15  ? 132.520 138.368 147.245 1.00 105.55 ? 15  GLU A OE1  1 
ATOM   2124 O OE2  . GLU B  1 15  ? 134.246 137.672 146.082 1.00 108.01 ? 15  GLU A OE2  1 
ATOM   2125 N N    . ASP B  1 16  ? 129.720 140.506 143.372 1.00 95.98  ? 16  ASP A N    1 
ATOM   2126 C CA   . ASP B  1 16  ? 129.119 139.808 142.241 1.00 96.75  ? 16  ASP A CA   1 
ATOM   2127 C C    . ASP B  1 16  ? 129.105 140.680 140.993 1.00 97.62  ? 16  ASP A C    1 
ATOM   2128 O O    . ASP B  1 16  ? 129.363 140.197 139.883 1.00 101.47 ? 16  ASP A O    1 
ATOM   2129 C CB   . ASP B  1 16  ? 127.708 139.355 142.602 1.00 97.31  ? 16  ASP A CB   1 
ATOM   2130 C CG   . ASP B  1 16  ? 127.674 138.512 143.860 1.00 99.52  ? 16  ASP A CG   1 
ATOM   2131 O OD1  . ASP B  1 16  ? 128.707 137.895 144.185 1.00 97.35  ? 16  ASP A OD1  1 
ATOM   2132 O OD2  . ASP B  1 16  ? 126.618 138.471 144.523 1.00 101.06 ? 16  ASP A OD2  1 
ATOM   2133 N N    . ASN B  1 17  ? 128.801 141.968 141.151 1.00 83.33  ? 17  ASN A N    1 
ATOM   2134 C CA   . ASN B  1 17  ? 128.807 142.867 140.004 1.00 88.13  ? 17  ASN A CA   1 
ATOM   2135 C C    . ASN B  1 17  ? 130.202 142.979 139.403 1.00 92.16  ? 17  ASN A C    1 
ATOM   2136 O O    . ASN B  1 17  ? 130.364 142.990 138.176 1.00 95.78  ? 17  ASN A O    1 
ATOM   2137 C CB   . ASN B  1 17  ? 128.282 144.241 140.416 1.00 89.17  ? 17  ASN A CB   1 
ATOM   2138 C CG   . ASN B  1 17  ? 126.928 144.168 141.093 1.00 92.32  ? 17  ASN A CG   1 
ATOM   2139 O OD1  . ASN B  1 17  ? 126.212 143.177 140.962 1.00 92.05  ? 17  ASN A OD1  1 
ATOM   2140 N ND2  . ASN B  1 17  ? 126.571 145.220 141.816 1.00 96.25  ? 17  ASN A ND2  1 
ATOM   2141 N N    . ALA B  1 18  ? 131.227 143.061 140.253 1.00 78.14  ? 18  ALA A N    1 
ATOM   2142 C CA   . ALA B  1 18  ? 132.594 143.118 139.751 1.00 81.65  ? 18  ALA A CA   1 
ATOM   2143 C C    . ALA B  1 18  ? 132.953 141.847 138.993 1.00 85.30  ? 18  ALA A C    1 
ATOM   2144 O O    . ALA B  1 18  ? 133.579 141.908 137.928 1.00 91.54  ? 18  ALA A O    1 
ATOM   2145 C CB   . ALA B  1 18  ? 133.567 143.344 140.909 1.00 78.75  ? 18  ALA A CB   1 
ATOM   2146 N N    . ARG B  1 19  ? 132.554 140.691 139.519 1.00 71.30  ? 19  ARG A N    1 
ATOM   2147 C CA   . ARG B  1 19  ? 132.825 139.436 138.822 1.00 69.19  ? 19  ARG A CA   1 
ATOM   2148 C C    . ARG B  1 19  ? 132.138 139.407 137.460 1.00 76.27  ? 19  ARG A C    1 
ATOM   2149 O O    . ARG B  1 19  ? 132.742 139.008 136.456 1.00 82.30  ? 19  ARG A O    1 
ATOM   2150 C CB   . ARG B  1 19  ? 132.365 138.266 139.685 1.00 64.47  ? 19  ARG A CB   1 
ATOM   2151 C CG   . ARG B  1 19  ? 132.745 136.900 139.160 1.00 70.40  ? 19  ARG A CG   1 
ATOM   2152 C CD   . ARG B  1 19  ? 132.132 135.824 140.029 1.00 70.96  ? 19  ARG A CD   1 
ATOM   2153 N NE   . ARG B  1 19  ? 132.435 136.045 141.437 1.00 70.99  ? 19  ARG A NE   1 
ATOM   2154 C CZ   . ARG B  1 19  ? 131.782 135.478 142.441 1.00 73.34  ? 19  ARG A CZ   1 
ATOM   2155 N NH1  . ARG B  1 19  ? 130.766 134.660 142.230 1.00 75.23  ? 19  ARG A NH1  1 
ATOM   2156 N NH2  . ARG B  1 19  ? 132.156 135.744 143.689 1.00 72.22  ? 19  ARG A NH2  1 
ATOM   2157 N N    . PHE B  1 20  ? 130.881 139.846 137.409 1.00 64.58  ? 20  PHE A N    1 
ATOM   2158 C CA   . PHE B  1 20  ? 130.138 139.868 136.152 1.00 62.39  ? 20  PHE A CA   1 
ATOM   2159 C C    . PHE B  1 20  ? 130.825 140.768 135.126 1.00 70.53  ? 20  PHE A C    1 
ATOM   2160 O O    . PHE B  1 20  ? 131.023 140.378 133.967 1.00 74.89  ? 20  PHE A O    1 
ATOM   2161 C CB   . PHE B  1 20  ? 128.711 140.342 136.429 1.00 56.86  ? 20  PHE A CB   1 
ATOM   2162 C CG   . PHE B  1 20  ? 127.689 139.812 135.466 1.00 65.19  ? 20  PHE A CG   1 
ATOM   2163 C CD1  . PHE B  1 20  ? 127.718 138.492 135.060 1.00 67.25  ? 20  PHE A CD1  1 
ATOM   2164 C CD2  . PHE B  1 20  ? 126.679 140.631 134.997 1.00 65.24  ? 20  PHE A CD2  1 
ATOM   2165 C CE1  . PHE B  1 20  ? 126.771 138.008 134.182 1.00 68.94  ? 20  PHE A CE1  1 
ATOM   2166 C CE2  . PHE B  1 20  ? 125.730 140.148 134.124 1.00 65.38  ? 20  PHE A CE2  1 
ATOM   2167 C CZ   . PHE B  1 20  ? 125.775 138.835 133.717 1.00 66.88  ? 20  PHE A CZ   1 
ATOM   2168 N N    . LEU B  1 21  ? 131.213 141.974 135.549 1.00 65.33  ? 21  LEU A N    1 
ATOM   2169 C CA   . LEU B  1 21  ? 131.858 142.909 134.635 1.00 65.95  ? 21  LEU A CA   1 
ATOM   2170 C C    . LEU B  1 21  ? 133.191 142.366 134.133 1.00 72.05  ? 21  LEU A C    1 
ATOM   2171 O O    . LEU B  1 21  ? 133.508 142.470 132.938 1.00 78.16  ? 21  LEU A O    1 
ATOM   2172 C CB   . LEU B  1 21  ? 132.052 144.255 135.332 1.00 61.93  ? 21  LEU A CB   1 
ATOM   2173 C CG   . LEU B  1 21  ? 132.696 145.383 134.527 1.00 70.70  ? 21  LEU A CG   1 
ATOM   2174 C CD1  . LEU B  1 21  ? 131.834 145.732 133.326 1.00 72.90  ? 21  LEU A CD1  1 
ATOM   2175 C CD2  . LEU B  1 21  ? 132.915 146.601 135.408 1.00 70.66  ? 21  LEU A CD2  1 
ATOM   2176 N N    . LEU B  1 22  ? 133.990 141.782 135.032 1.00 61.20  ? 22  LEU A N    1 
ATOM   2177 C CA   . LEU B  1 22  ? 135.278 141.241 134.624 1.00 62.63  ? 22  LEU A CA   1 
ATOM   2178 C C    . LEU B  1 22  ? 135.106 140.116 133.612 1.00 66.00  ? 22  LEU A C    1 
ATOM   2179 O O    . LEU B  1 22  ? 135.829 140.055 132.604 1.00 74.77  ? 22  LEU A O    1 
ATOM   2180 C CB   . LEU B  1 22  ? 136.044 140.752 135.852 1.00 55.65  ? 22  LEU A CB   1 
ATOM   2181 C CG   . LEU B  1 22  ? 137.519 140.402 135.670 1.00 61.76  ? 22  LEU A CG   1 
ATOM   2182 C CD1  . LEU B  1 22  ? 138.285 141.593 135.120 1.00 64.80  ? 22  LEU A CD1  1 
ATOM   2183 C CD2  . LEU B  1 22  ? 138.120 139.943 136.983 1.00 61.70  ? 22  LEU A CD2  1 
ATOM   2184 N N    . LEU B  1 23  ? 134.145 139.222 133.852 1.00 52.22  ? 23  LEU A N    1 
ATOM   2185 C CA   . LEU B  1 23  ? 133.913 138.138 132.906 1.00 55.84  ? 23  LEU A CA   1 
ATOM   2186 C C    . LEU B  1 23  ? 133.489 138.676 131.544 1.00 67.31  ? 23  LEU A C    1 
ATOM   2187 O O    . LEU B  1 23  ? 133.957 138.195 130.503 1.00 71.63  ? 23  LEU A O    1 
ATOM   2188 C CB   . LEU B  1 23  ? 132.863 137.175 133.458 1.00 53.86  ? 23  LEU A CB   1 
ATOM   2189 C CG   . LEU B  1 23  ? 132.609 135.916 132.636 1.00 51.52  ? 23  LEU A CG   1 
ATOM   2190 C CD1  . LEU B  1 23  ? 133.896 135.135 132.454 1.00 57.19  ? 23  LEU A CD1  1 
ATOM   2191 C CD2  . LEU B  1 23  ? 131.555 135.055 133.303 1.00 56.85  ? 23  LEU A CD2  1 
ATOM   2192 N N    . ALA B  1 24  ? 132.608 139.682 131.527 1.00 57.36  ? 24  ALA A N    1 
ATOM   2193 C CA   . ALA B  1 24  ? 132.175 140.240 130.249 1.00 54.36  ? 24  ALA A CA   1 
ATOM   2194 C C    . ALA B  1 24  ? 133.347 140.830 129.474 1.00 59.61  ? 24  ALA A C    1 
ATOM   2195 O O    . ALA B  1 24  ? 133.501 140.589 128.265 1.00 68.18  ? 24  ALA A O    1 
ATOM   2196 C CB   . ALA B  1 24  ? 131.094 141.295 130.483 1.00 54.78  ? 24  ALA A CB   1 
ATOM   2197 N N    . ALA B  1 25  ? 134.199 141.602 130.154 1.00 57.49  ? 25  ALA A N    1 
ATOM   2198 C CA   . ALA B  1 25  ? 135.336 142.210 129.467 1.00 60.95  ? 25  ALA A CA   1 
ATOM   2199 C C    . ALA B  1 25  ? 136.286 141.149 128.918 1.00 65.60  ? 25  ALA A C    1 
ATOM   2200 O O    . ALA B  1 25  ? 136.761 141.253 127.774 1.00 72.58  ? 25  ALA A O    1 
ATOM   2201 C CB   . ALA B  1 25  ? 136.075 143.153 130.412 1.00 60.24  ? 25  ALA A CB   1 
ATOM   2202 N N    . LEU B  1 26  ? 136.567 140.115 129.714 1.00 56.54  ? 26  LEU A N    1 
ATOM   2203 C CA   . LEU B  1 26  ? 137.462 139.067 129.244 1.00 55.06  ? 26  LEU A CA   1 
ATOM   2204 C C    . LEU B  1 26  ? 136.886 138.361 128.022 1.00 57.68  ? 26  LEU A C    1 
ATOM   2205 O O    . LEU B  1 26  ? 137.613 138.063 127.065 1.00 61.82  ? 26  LEU A O    1 
ATOM   2206 C CB   . LEU B  1 26  ? 137.732 138.069 130.369 1.00 60.49  ? 26  LEU A CB   1 
ATOM   2207 C CG   . LEU B  1 26  ? 138.476 138.619 131.587 1.00 55.07  ? 26  LEU A CG   1 
ATOM   2208 C CD1  . LEU B  1 26  ? 138.795 137.507 132.570 1.00 56.51  ? 26  LEU A CD1  1 
ATOM   2209 C CD2  . LEU B  1 26  ? 139.740 139.342 131.170 1.00 55.53  ? 26  LEU A CD2  1 
ATOM   2210 N N    . ILE B  1 27  ? 135.575 138.101 128.025 1.00 49.90  ? 27  ILE A N    1 
ATOM   2211 C CA   . ILE B  1 27  ? 134.957 137.438 126.880 1.00 55.31  ? 27  ILE A CA   1 
ATOM   2212 C C    . ILE B  1 27  ? 135.069 138.300 125.628 1.00 58.65  ? 27  ILE A C    1 
ATOM   2213 O O    . ILE B  1 27  ? 135.337 137.793 124.529 1.00 63.05  ? 27  ILE A O    1 
ATOM   2214 C CB   . ILE B  1 27  ? 133.490 137.088 127.193 1.00 50.38  ? 27  ILE A CB   1 
ATOM   2215 C CG1  . ILE B  1 27  ? 133.419 136.007 128.270 1.00 48.92  ? 27  ILE A CG1  1 
ATOM   2216 C CG2  . ILE B  1 27  ? 132.780 136.630 125.937 1.00 55.97  ? 27  ILE A CG2  1 
ATOM   2217 C CD1  . ILE B  1 27  ? 132.014 135.626 128.650 1.00 53.82  ? 27  ILE A CD1  1 
ATOM   2218 N N    . VAL B  1 28  ? 134.864 139.611 125.768 1.00 58.81  ? 28  VAL A N    1 
ATOM   2219 C CA   . VAL B  1 28  ? 134.950 140.489 124.600 1.00 58.33  ? 28  VAL A CA   1 
ATOM   2220 C C    . VAL B  1 28  ? 136.360 140.464 124.009 1.00 62.74  ? 28  VAL A C    1 
ATOM   2221 O O    . VAL B  1 28  ? 136.546 140.364 122.784 1.00 69.45  ? 28  VAL A O    1 
ATOM   2222 C CB   . VAL B  1 28  ? 134.516 141.916 124.969 1.00 53.60  ? 28  VAL A CB   1 
ATOM   2223 C CG1  . VAL B  1 28  ? 134.807 142.868 123.825 1.00 56.09  ? 28  VAL A CG1  1 
ATOM   2224 C CG2  . VAL B  1 28  ? 133.043 141.940 125.317 1.00 55.09  ? 28  VAL A CG2  1 
ATOM   2225 N N    . LEU B  1 29  ? 137.375 140.555 124.872 1.00 53.72  ? 29  LEU A N    1 
ATOM   2226 C CA   . LEU B  1 29  ? 138.748 140.506 124.371 1.00 52.98  ? 29  LEU A CA   1 
ATOM   2227 C C    . LEU B  1 29  ? 139.032 139.177 123.674 1.00 59.82  ? 29  LEU A C    1 
ATOM   2228 O O    . LEU B  1 29  ? 139.683 139.139 122.616 1.00 67.07  ? 29  LEU A O    1 
ATOM   2229 C CB   . LEU B  1 29  ? 139.735 140.738 125.511 1.00 52.88  ? 29  LEU A CB   1 
ATOM   2230 C CG   . LEU B  1 29  ? 139.665 142.104 126.195 1.00 54.35  ? 29  LEU A CG   1 
ATOM   2231 C CD1  . LEU B  1 29  ? 140.715 142.214 127.281 1.00 56.03  ? 29  LEU A CD1  1 
ATOM   2232 C CD2  . LEU B  1 29  ? 139.828 143.215 125.177 1.00 58.00  ? 29  LEU A CD2  1 
ATOM   2233 N N    . TYR B  1 30  ? 138.544 138.082 124.254 1.00 52.24  ? 30  TYR A N    1 
ATOM   2234 C CA   . TYR B  1 30  ? 138.722 136.767 123.644 1.00 53.70  ? 30  TYR A CA   1 
ATOM   2235 C C    . TYR B  1 30  ? 138.125 136.730 122.242 1.00 60.61  ? 30  TYR A C    1 
ATOM   2236 O O    . TYR B  1 30  ? 138.754 136.225 121.298 1.00 64.26  ? 30  TYR A O    1 
ATOM   2237 C CB   . TYR B  1 30  ? 138.077 135.709 124.541 1.00 52.11  ? 30  TYR A CB   1 
ATOM   2238 C CG   . TYR B  1 30  ? 138.536 134.293 124.315 1.00 54.93  ? 30  TYR A CG   1 
ATOM   2239 C CD1  . TYR B  1 30  ? 139.827 133.901 124.633 1.00 53.15  ? 30  TYR A CD1  1 
ATOM   2240 C CD2  . TYR B  1 30  ? 137.667 133.332 123.817 1.00 56.47  ? 30  TYR A CD2  1 
ATOM   2241 C CE1  . TYR B  1 30  ? 140.245 132.604 124.437 1.00 52.67  ? 30  TYR A CE1  1 
ATOM   2242 C CE2  . TYR B  1 30  ? 138.078 132.036 123.622 1.00 55.80  ? 30  TYR A CE2  1 
ATOM   2243 C CZ   . TYR B  1 30  ? 139.368 131.675 123.933 1.00 54.14  ? 30  TYR A CZ   1 
ATOM   2244 O OH   . TYR B  1 30  ? 139.782 130.383 123.737 1.00 63.14  ? 30  TYR A OH   1 
ATOM   2245 N N    . LEU B  1 31  ? 136.916 137.275 122.086 1.00 52.16  ? 31  LEU A N    1 
ATOM   2246 C CA   . LEU B  1 31  ? 136.267 137.266 120.779 1.00 46.94  ? 31  LEU A CA   1 
ATOM   2247 C C    . LEU B  1 31  ? 137.072 138.056 119.753 1.00 49.91  ? 31  LEU A C    1 
ATOM   2248 O O    . LEU B  1 31  ? 137.259 137.601 118.616 1.00 59.47  ? 31  LEU A O    1 
ATOM   2249 C CB   . LEU B  1 31  ? 134.852 137.827 120.885 1.00 43.74  ? 31  LEU A CB   1 
ATOM   2250 C CG   . LEU B  1 31  ? 133.823 136.992 121.647 1.00 45.83  ? 31  LEU A CG   1 
ATOM   2251 C CD1  . LEU B  1 31  ? 132.443 137.606 121.525 1.00 45.12  ? 31  LEU A CD1  1 
ATOM   2252 C CD2  . LEU B  1 31  ? 133.817 135.561 121.144 1.00 53.50  ? 31  LEU A CD2  1 
ATOM   2253 N N    . LEU B  1 32  ? 137.559 139.236 120.136 1.00 47.93  ? 32  LEU A N    1 
ATOM   2254 C CA   . LEU B  1 32  ? 138.312 140.040 119.173 1.00 47.40  ? 32  LEU A CA   1 
ATOM   2255 C C    . LEU B  1 32  ? 139.578 139.321 118.719 1.00 53.49  ? 32  LEU A C    1 
ATOM   2256 O O    . LEU B  1 32  ? 139.886 139.256 117.515 1.00 60.52  ? 32  LEU A O    1 
ATOM   2257 C CB   . LEU B  1 32  ? 138.649 141.405 119.775 1.00 47.55  ? 32  LEU A CB   1 
ATOM   2258 C CG   . LEU B  1 32  ? 137.461 142.337 120.000 1.00 45.36  ? 32  LEU A CG   1 
ATOM   2259 C CD1  . LEU B  1 32  ? 137.918 143.668 120.561 1.00 49.16  ? 32  LEU A CD1  1 
ATOM   2260 C CD2  . LEU B  1 32  ? 136.697 142.538 118.705 1.00 48.45  ? 32  LEU A CD2  1 
ATOM   2261 N N    . GLY B  1 33  ? 140.320 138.748 119.669 1.00 53.84  ? 33  GLY A N    1 
ATOM   2262 C CA   . GLY B  1 33  ? 141.534 138.033 119.295 1.00 52.34  ? 33  GLY A CA   1 
ATOM   2263 C C    . GLY B  1 33  ? 141.260 136.859 118.373 1.00 58.59  ? 33  GLY A C    1 
ATOM   2264 O O    . GLY B  1 33  ? 141.947 136.663 117.359 1.00 63.22  ? 33  GLY A O    1 
ATOM   2265 N N    . GLY B  1 34  ? 140.240 136.064 118.708 1.00 59.64  ? 34  GLY A N    1 
ATOM   2266 C CA   . GLY B  1 34  ? 139.912 134.926 117.866 1.00 53.54  ? 34  GLY A CA   1 
ATOM   2267 C C    . GLY B  1 34  ? 139.522 135.336 116.457 1.00 53.93  ? 34  GLY A C    1 
ATOM   2268 O O    . GLY B  1 34  ? 139.920 134.694 115.481 1.00 57.50  ? 34  GLY A O    1 
ATOM   2269 N N    . ALA B  1 35  ? 138.743 136.410 116.333 1.00 47.47  ? 35  ALA A N    1 
ATOM   2270 C CA   . ALA B  1 35  ? 138.354 136.875 115.007 1.00 50.36  ? 35  ALA A CA   1 
ATOM   2271 C C    . ALA B  1 35  ? 139.573 137.247 114.180 1.00 46.27  ? 35  ALA A C    1 
ATOM   2272 O O    . ALA B  1 35  ? 139.691 136.859 113.006 1.00 55.52  ? 35  ALA A O    1 
ATOM   2273 C CB   . ALA B  1 35  ? 137.400 138.062 115.126 1.00 50.29  ? 35  ALA A CB   1 
ATOM   2274 N N    . ALA B  1 36  ? 140.506 137.989 114.781 1.00 50.54  ? 36  ALA A N    1 
ATOM   2275 C CA   . ALA B  1 36  ? 141.704 138.371 114.041 1.00 51.51  ? 36  ALA A CA   1 
ATOM   2276 C C    . ALA B  1 36  ? 142.460 137.145 113.547 1.00 58.03  ? 36  ALA A C    1 
ATOM   2277 O O    . ALA B  1 36  ? 142.831 137.054 112.365 1.00 66.55  ? 36  ALA A O    1 
ATOM   2278 C CB   . ALA B  1 36  ? 142.605 139.245 114.913 1.00 52.82  ? 36  ALA A CB   1 
ATOM   2279 N N    . VAL B  1 37  ? 142.671 136.169 114.435 1.00 54.36  ? 37  VAL A N    1 
ATOM   2280 C CA   . VAL B  1 37  ? 143.465 134.999 114.059 1.00 52.68  ? 37  VAL A CA   1 
ATOM   2281 C C    . VAL B  1 37  ? 142.784 134.225 112.934 1.00 60.65  ? 37  VAL A C    1 
ATOM   2282 O O    . VAL B  1 37  ? 143.425 133.821 111.953 1.00 64.91  ? 37  VAL A O    1 
ATOM   2283 C CB   . VAL B  1 37  ? 143.721 134.108 115.285 1.00 54.28  ? 37  VAL A CB   1 
ATOM   2284 C CG1  . VAL B  1 37  ? 144.473 132.859 114.875 1.00 54.22  ? 37  VAL A CG1  1 
ATOM   2285 C CG2  . VAL B  1 37  ? 144.502 134.871 116.338 1.00 58.53  ? 37  VAL A CG2  1 
ATOM   2286 N N    . PHE B  1 38  ? 141.471 134.012 113.049 1.00 56.58  ? 38  PHE A N    1 
ATOM   2287 C CA   . PHE B  1 38  ? 140.776 133.213 112.042 1.00 47.94  ? 38  PHE A CA   1 
ATOM   2288 C C    . PHE B  1 38  ? 140.801 133.887 110.677 1.00 55.86  ? 38  PHE A C    1 
ATOM   2289 O O    . PHE B  1 38  ? 141.012 133.224 109.649 1.00 56.37  ? 38  PHE A O    1 
ATOM   2290 C CB   . PHE B  1 38  ? 139.339 132.945 112.483 1.00 46.89  ? 38  PHE A CB   1 
ATOM   2291 C CG   . PHE B  1 38  ? 139.177 131.702 113.304 1.00 47.32  ? 38  PHE A CG   1 
ATOM   2292 C CD1  . PHE B  1 38  ? 139.320 130.456 112.726 1.00 51.46  ? 38  PHE A CD1  1 
ATOM   2293 C CD2  . PHE B  1 38  ? 138.870 131.779 114.647 1.00 49.16  ? 38  PHE A CD2  1 
ATOM   2294 C CE1  . PHE B  1 38  ? 139.167 129.313 113.476 1.00 55.24  ? 38  PHE A CE1  1 
ATOM   2295 C CE2  . PHE B  1 38  ? 138.715 130.639 115.402 1.00 48.18  ? 38  PHE A CE2  1 
ATOM   2296 C CZ   . PHE B  1 38  ? 138.862 129.404 114.816 1.00 51.77  ? 38  PHE A CZ   1 
ATOM   2297 N N    . SER B  1 39  ? 140.569 135.203 110.635 1.00 55.87  ? 39  SER A N    1 
ATOM   2298 C CA   . SER B  1 39  ? 140.647 135.900 109.355 1.00 48.92  ? 39  SER A CA   1 
ATOM   2299 C C    . SER B  1 39  ? 142.023 135.732 108.732 1.00 52.33  ? 39  SER A C    1 
ATOM   2300 O O    . SER B  1 39  ? 142.154 135.359 107.550 1.00 63.71  ? 39  SER A O    1 
ATOM   2301 C CB   . SER B  1 39  ? 140.321 137.378 109.539 1.00 52.90  ? 39  SER A CB   1 
ATOM   2302 O OG   . SER B  1 39  ? 140.721 138.126 108.407 1.00 65.63  ? 39  SER A OG   1 
ATOM   2303 N N    . ALA B  1 40  ? 143.070 135.967 109.533 1.00 53.51  ? 40  ALA A N    1 
ATOM   2304 C CA   . ALA B  1 40  ? 144.428 135.845 109.023 1.00 55.07  ? 40  ALA A CA   1 
ATOM   2305 C C    . ALA B  1 40  ? 144.719 134.437 108.521 1.00 57.47  ? 40  ALA A C    1 
ATOM   2306 O O    . ALA B  1 40  ? 145.571 134.257 107.645 1.00 60.67  ? 40  ALA A O    1 
ATOM   2307 C CB   . ALA B  1 40  ? 145.435 136.236 110.104 1.00 57.06  ? 40  ALA A CB   1 
ATOM   2308 N N    . LEU B  1 41  ? 144.033 133.432 109.064 1.00 66.24  ? 41  LEU A N    1 
ATOM   2309 C CA   . LEU B  1 41  ? 144.285 132.068 108.615 1.00 59.86  ? 41  LEU A CA   1 
ATOM   2310 C C    . LEU B  1 41  ? 143.495 131.668 107.372 1.00 59.24  ? 41  LEU A C    1 
ATOM   2311 O O    . LEU B  1 41  ? 143.952 130.799 106.623 1.00 59.31  ? 41  LEU A O    1 
ATOM   2312 C CB   . LEU B  1 41  ? 143.984 131.072 109.741 1.00 58.04  ? 41  LEU A CB   1 
ATOM   2313 C CG   . LEU B  1 41  ? 145.056 130.914 110.817 1.00 57.26  ? 41  LEU A CG   1 
ATOM   2314 C CD1  . LEU B  1 41  ? 144.599 129.944 111.891 1.00 56.29  ? 41  LEU A CD1  1 
ATOM   2315 C CD2  . LEU B  1 41  ? 146.360 130.447 110.202 1.00 58.59  ? 41  LEU A CD2  1 
ATOM   2316 N N    . GLU B  1 42  ? 142.321 132.264 107.121 1.00 66.69  ? 42  GLU A N    1 
ATOM   2317 C CA   . GLU B  1 42  ? 141.428 131.721 106.097 1.00 58.94  ? 42  GLU A CA   1 
ATOM   2318 C C    . GLU B  1 42  ? 141.224 132.586 104.852 1.00 64.34  ? 42  GLU A C    1 
ATOM   2319 O O    . GLU B  1 42  ? 140.713 132.069 103.840 1.00 69.62  ? 42  GLU A O    1 
ATOM   2320 C CB   . GLU B  1 42  ? 140.056 131.420 106.713 1.00 62.64  ? 42  GLU A CB   1 
ATOM   2321 C CG   . GLU B  1 42  ? 140.115 130.495 107.913 1.00 66.30  ? 42  GLU A CG   1 
ATOM   2322 C CD   . GLU B  1 42  ? 140.183 129.036 107.518 1.00 73.52  ? 42  GLU A CD   1 
ATOM   2323 O OE1  . GLU B  1 42  ? 140.164 128.745 106.305 1.00 79.66  ? 42  GLU A OE1  1 
ATOM   2324 O OE2  . GLU B  1 42  ? 140.259 128.175 108.418 1.00 75.46  ? 42  GLU A OE2  1 
ATOM   2325 N N    . LEU B  1 43  ? 141.592 133.873 104.889 1.00 70.35  ? 43  LEU A N    1 
ATOM   2326 C CA   . LEU B  1 43  ? 141.193 134.768 103.801 1.00 70.91  ? 43  LEU A CA   1 
ATOM   2327 C C    . LEU B  1 43  ? 141.736 134.308 102.443 1.00 75.80  ? 43  LEU A C    1 
ATOM   2328 O O    . LEU B  1 43  ? 141.011 134.310 101.437 1.00 79.12  ? 43  LEU A O    1 
ATOM   2329 C CB   . LEU B  1 43  ? 141.652 136.192 104.110 1.00 67.78  ? 43  LEU A CB   1 
ATOM   2330 C CG   . LEU B  1 43  ? 141.157 137.278 103.160 1.00 67.28  ? 43  LEU A CG   1 
ATOM   2331 C CD1  . LEU B  1 43  ? 139.643 137.267 103.088 1.00 64.03  ? 43  LEU A CD1  1 
ATOM   2332 C CD2  . LEU B  1 43  ? 141.662 138.636 103.602 1.00 70.85  ? 43  LEU A CD2  1 
ATOM   2333 N N    . ALA B  1 44  ? 143.017 133.931 102.393 1.00 72.75  ? 44  ALA A N    1 
ATOM   2334 C CA   . ALA B  1 44  ? 143.643 133.618 101.110 1.00 72.23  ? 44  ALA A CA   1 
ATOM   2335 C C    . ALA B  1 44  ? 143.020 132.386 100.462 1.00 79.96  ? 44  ALA A C    1 
ATOM   2336 O O    . ALA B  1 44  ? 142.779 132.366 99.245  1.00 86.73  ? 44  ALA A O    1 
ATOM   2337 C CB   . ALA B  1 44  ? 145.146 133.417 101.298 1.00 71.56  ? 44  ALA A CB   1 
ATOM   2338 N N    . HIS B  1 45  ? 142.760 131.347 101.254 1.00 77.47  ? 45  HIS A N    1 
ATOM   2339 C CA   . HIS B  1 45  ? 142.107 130.159 100.719 1.00 74.64  ? 45  HIS A CA   1 
ATOM   2340 C C    . HIS B  1 45  ? 140.724 130.499 100.183 1.00 78.65  ? 45  HIS A C    1 
ATOM   2341 O O    . HIS B  1 45  ? 140.327 130.013 99.111  1.00 78.59  ? 45  HIS A O    1 
ATOM   2342 C CB   . HIS B  1 45  ? 142.023 129.078 101.796 1.00 73.79  ? 45  HIS A CB   1 
ATOM   2343 C CG   . HIS B  1 45  ? 141.541 127.754 101.291 1.00 80.62  ? 45  HIS A CG   1 
ATOM   2344 N ND1  . HIS B  1 45  ? 142.370 126.852 100.665 1.00 82.01  ? 45  HIS A ND1  1 
ATOM   2345 C CD2  . HIS B  1 45  ? 140.315 127.177 101.328 1.00 83.43  ? 45  HIS A CD2  1 
ATOM   2346 C CE1  . HIS B  1 45  ? 141.676 125.777 100.335 1.00 82.91  ? 45  HIS A CE1  1 
ATOM   2347 N NE2  . HIS B  1 45  ? 140.428 125.949 100.724 1.00 82.30  ? 45  HIS A NE2  1 
ATOM   2348 N N    . GLU B  1 46  ? 139.974 131.341 100.903 1.00 81.79  ? 46  GLU A N    1 
ATOM   2349 C CA   . GLU B  1 46  ? 138.660 131.727 100.393 1.00 77.56  ? 46  GLU A CA   1 
ATOM   2350 C C    . GLU B  1 46  ? 138.778 132.398 99.027  1.00 79.56  ? 46  GLU A C    1 
ATOM   2351 O O    . GLU B  1 46  ? 138.032 132.079 98.090  1.00 87.18  ? 46  GLU A O    1 
ATOM   2352 C CB   . GLU B  1 46  ? 137.956 132.651 101.387 1.00 80.96  ? 46  GLU A CB   1 
ATOM   2353 C CG   . GLU B  1 46  ? 136.542 133.019 100.970 1.00 82.90  ? 46  GLU A CG   1 
ATOM   2354 C CD   . GLU B  1 46  ? 136.133 134.399 101.440 1.00 89.83  ? 46  GLU A CD   1 
ATOM   2355 O OE1  . GLU B  1 46  ? 137.026 135.209 101.762 1.00 96.28  ? 46  GLU A OE1  1 
ATOM   2356 O OE2  . GLU B  1 46  ? 134.918 134.674 101.491 1.00 88.94  ? 46  GLU A OE2  1 
ATOM   2357 N N    . ARG B  1 47  ? 139.721 133.337 98.898  1.00 78.37  ? 47  ARG A N    1 
ATOM   2358 C CA   . ARG B  1 47  ? 139.863 134.052 97.631  1.00 79.03  ? 47  ARG A CA   1 
ATOM   2359 C C    . ARG B  1 47  ? 140.239 133.104 96.494  1.00 83.61  ? 47  ARG A C    1 
ATOM   2360 O O    . ARG B  1 47  ? 139.701 133.211 95.379  1.00 87.87  ? 47  ARG A O    1 
ATOM   2361 C CB   . ARG B  1 47  ? 140.903 135.162 97.765  1.00 80.05  ? 47  ARG A CB   1 
ATOM   2362 C CG   . ARG B  1 47  ? 140.411 136.373 98.535  1.00 84.66  ? 47  ARG A CG   1 
ATOM   2363 C CD   . ARG B  1 47  ? 141.517 137.393 98.726  1.00 86.39  ? 47  ARG A CD   1 
ATOM   2364 N NE   . ARG B  1 47  ? 141.049 138.573 99.443  1.00 88.84  ? 47  ARG A NE   1 
ATOM   2365 C CZ   . ARG B  1 47  ? 141.837 139.530 99.904  1.00 89.68  ? 47  ARG A CZ   1 
ATOM   2366 N NH1  . ARG B  1 47  ? 143.152 139.478 99.749  1.00 88.77  ? 47  ARG A NH1  1 
ATOM   2367 N NH2  . ARG B  1 47  ? 141.300 140.568 100.538 1.00 88.53  ? 47  ARG A NH2  1 
ATOM   2368 N N    . GLN B  1 48  ? 141.160 132.174 96.751  1.00 79.71  ? 48  GLN A N    1 
ATOM   2369 C CA   . GLN B  1 48  ? 141.555 131.240 95.703  1.00 74.06  ? 48  GLN A CA   1 
ATOM   2370 C C    . GLN B  1 48  ? 140.381 130.371 95.260  1.00 78.16  ? 48  GLN A C    1 
ATOM   2371 O O    . GLN B  1 48  ? 140.199 130.128 94.059  1.00 83.11  ? 48  GLN A O    1 
ATOM   2372 C CB   . GLN B  1 48  ? 142.714 130.367 96.180  1.00 74.80  ? 48  GLN A CB   1 
ATOM   2373 C CG   . GLN B  1 48  ? 144.021 131.118 96.328  1.00 78.69  ? 48  GLN A CG   1 
ATOM   2374 C CD   . GLN B  1 48  ? 145.192 130.195 96.597  1.00 86.06  ? 48  GLN A CD   1 
ATOM   2375 O OE1  . GLN B  1 48  ? 145.017 128.998 96.820  1.00 87.90  ? 48  GLN A OE1  1 
ATOM   2376 N NE2  . GLN B  1 48  ? 146.396 130.751 96.574  1.00 87.39  ? 48  GLN A NE2  1 
ATOM   2377 N N    . ALA B  1 49  ? 139.570 129.904 96.212  1.00 77.67  ? 49  ALA A N    1 
ATOM   2378 C CA   . ALA B  1 49  ? 138.414 129.096 95.839  1.00 74.23  ? 49  ALA A CA   1 
ATOM   2379 C C    . ALA B  1 49  ? 137.438 129.889 94.976  1.00 73.70  ? 49  ALA A C    1 
ATOM   2380 O O    . ALA B  1 49  ? 136.903 129.371 93.980  1.00 71.33  ? 49  ALA A O    1 
ATOM   2381 C CB   . ALA B  1 49  ? 137.714 128.567 97.088  1.00 75.83  ? 49  ALA A CB   1 
ATOM   2382 N N    . LYS B  1 50  ? 137.193 131.149 95.336  1.00 78.25  ? 50  LYS A N    1 
ATOM   2383 C CA   . LYS B  1 50  ? 136.289 131.966 94.529  1.00 75.24  ? 50  LYS A CA   1 
ATOM   2384 C C    . LYS B  1 50  ? 136.809 132.122 93.103  1.00 77.81  ? 50  LYS A C    1 
ATOM   2385 O O    . LYS B  1 50  ? 136.046 131.987 92.134  1.00 79.55  ? 50  LYS A O    1 
ATOM   2386 C CB   . LYS B  1 50  ? 136.091 133.336 95.174  1.00 73.22  ? 50  LYS A CB   1 
ATOM   2387 C CG   . LYS B  1 50  ? 135.275 133.321 96.453  1.00 72.79  ? 50  LYS A CG   1 
ATOM   2388 C CD   . LYS B  1 50  ? 135.026 134.734 96.952  1.00 78.26  ? 50  LYS A CD   1 
ATOM   2389 C CE   . LYS B  1 50  ? 134.305 134.737 98.288  1.00 74.99  ? 50  LYS A CE   1 
ATOM   2390 N NZ   . LYS B  1 50  ? 132.961 134.112 98.199  1.00 75.97  ? 50  LYS A NZ   1 
ATOM   2391 N N    . GLN B  1 51  ? 138.105 132.400 92.955  1.00 83.83  ? 51  GLN A N    1 
ATOM   2392 C CA   . GLN B  1 51  ? 138.661 132.557 91.612  1.00 82.58  ? 51  GLN A CA   1 
ATOM   2393 C C    . GLN B  1 51  ? 138.545 131.267 90.808  1.00 85.79  ? 51  GLN A C    1 
ATOM   2394 O O    . GLN B  1 51  ? 138.232 131.293 89.607  1.00 86.92  ? 51  GLN A O    1 
ATOM   2395 C CB   . GLN B  1 51  ? 140.116 133.006 91.693  1.00 79.91  ? 51  GLN A CB   1 
ATOM   2396 C CG   . GLN B  1 51  ? 140.912 132.730 90.432  1.00 84.10  ? 51  GLN A CG   1 
ATOM   2397 C CD   . GLN B  1 51  ? 141.923 133.816 90.130  1.00 90.94  ? 51  GLN A CD   1 
ATOM   2398 O OE1  . GLN B  1 51  ? 142.635 134.281 91.021  1.00 95.30  ? 51  GLN A OE1  1 
ATOM   2399 N NE2  . GLN B  1 51  ? 141.992 134.230 88.871  1.00 88.71  ? 51  GLN A NE2  1 
ATOM   2400 N N    . ARG B  1 52  ? 138.796 130.123 91.452  1.00 87.34  ? 52  ARG A N    1 
ATOM   2401 C CA   . ARG B  1 52  ? 138.681 128.848 90.750  1.00 81.96  ? 52  ARG A CA   1 
ATOM   2402 C C    . ARG B  1 52  ? 137.261 128.626 90.239  1.00 85.67  ? 52  ARG A C    1 
ATOM   2403 O O    . ARG B  1 52  ? 137.056 128.218 89.086  1.00 89.27  ? 52  ARG A O    1 
ATOM   2404 C CB   . ARG B  1 52  ? 139.103 127.704 91.669  1.00 83.25  ? 52  ARG A CB   1 
ATOM   2405 C CG   . ARG B  1 52  ? 139.407 126.405 90.950  1.00 82.36  ? 52  ARG A CG   1 
ATOM   2406 C CD   . ARG B  1 52  ? 139.326 125.218 91.896  1.00 86.18  ? 52  ARG A CD   1 
ATOM   2407 N NE   . ARG B  1 52  ? 139.999 125.475 93.163  1.00 87.99  ? 52  ARG A NE   1 
ATOM   2408 C CZ   . ARG B  1 52  ? 141.277 125.208 93.402  1.00 88.74  ? 52  ARG A CZ   1 
ATOM   2409 N NH1  . ARG B  1 52  ? 142.057 124.676 92.475  1.00 90.61  ? 52  ARG A NH1  1 
ATOM   2410 N NH2  . ARG B  1 52  ? 141.786 125.479 94.601  1.00 86.06  ? 52  ARG A NH2  1 
ATOM   2411 N N    . TRP B  1 53  ? 136.261 128.897 91.084  1.00 82.57  ? 53  TRP A N    1 
ATOM   2412 C CA   . TRP B  1 53  ? 134.882 128.723 90.637  1.00 78.77  ? 53  TRP A CA   1 
ATOM   2413 C C    . TRP B  1 53  ? 134.551 129.653 89.479  1.00 77.04  ? 53  TRP A C    1 
ATOM   2414 O O    . TRP B  1 53  ? 133.873 129.253 88.524  1.00 76.10  ? 53  TRP A O    1 
ATOM   2415 C CB   . TRP B  1 53  ? 133.901 128.959 91.782  1.00 78.80  ? 53  TRP A CB   1 
ATOM   2416 C CG   . TRP B  1 53  ? 132.536 129.340 91.281  1.00 77.85  ? 53  TRP A CG   1 
ATOM   2417 C CD1  . TRP B  1 53  ? 131.917 130.546 91.428  1.00 77.06  ? 53  TRP A CD1  1 
ATOM   2418 C CD2  . TRP B  1 53  ? 131.635 128.518 90.530  1.00 78.29  ? 53  TRP A CD2  1 
ATOM   2419 N NE1  . TRP B  1 53  ? 130.683 130.522 90.829  1.00 76.63  ? 53  TRP A NE1  1 
ATOM   2420 C CE2  . TRP B  1 53  ? 130.485 129.288 90.269  1.00 74.84  ? 53  TRP A CE2  1 
ATOM   2421 C CE3  . TRP B  1 53  ? 131.687 127.204 90.057  1.00 80.21  ? 53  TRP A CE3  1 
ATOM   2422 C CZ2  . TRP B  1 53  ? 129.400 128.791 89.557  1.00 72.04  ? 53  TRP A CZ2  1 
ATOM   2423 C CZ3  . TRP B  1 53  ? 130.605 126.712 89.351  1.00 74.46  ? 53  TRP A CZ3  1 
ATOM   2424 C CH2  . TRP B  1 53  ? 129.481 127.503 89.109  1.00 69.78  ? 53  TRP A CH2  1 
ATOM   2425 N N    . GLU B  1 54  ? 135.010 130.905 89.547  1.00 87.62  ? 54  GLU A N    1 
ATOM   2426 C CA   . GLU B  1 54  ? 134.733 131.833 88.453  1.00 86.81  ? 54  GLU A CA   1 
ATOM   2427 C C    . GLU B  1 54  ? 135.316 131.323 87.142  1.00 86.13  ? 54  GLU A C    1 
ATOM   2428 O O    . GLU B  1 54  ? 134.653 131.358 86.096  1.00 86.88  ? 54  GLU A O    1 
ATOM   2429 C CB   . GLU B  1 54  ? 135.282 133.218 88.783  1.00 88.29  ? 54  GLU A CB   1 
ATOM   2430 C CG   . GLU B  1 54  ? 135.201 134.204 87.633  1.00 91.39  ? 54  GLU A CG   1 
ATOM   2431 C CD   . GLU B  1 54  ? 133.859 134.902 87.553  1.00 96.04  ? 54  GLU A CD   1 
ATOM   2432 O OE1  . GLU B  1 54  ? 133.180 135.008 88.596  1.00 97.27  ? 54  GLU A OE1  1 
ATOM   2433 O OE2  . GLU B  1 54  ? 133.482 135.344 86.447  1.00 93.74  ? 54  GLU A OE2  1 
ATOM   2434 N N    . GLU B  1 55  ? 136.560 130.835 87.178  1.00 95.36  ? 55  GLU A N    1 
ATOM   2435 C CA   . GLU B  1 55  ? 137.178 130.332 85.955  1.00 94.09  ? 55  GLU A CA   1 
ATOM   2436 C C    . GLU B  1 55  ? 136.425 129.128 85.405  1.00 95.92  ? 55  GLU A C    1 
ATOM   2437 O O    . GLU B  1 55  ? 136.202 129.025 84.192  1.00 95.17  ? 55  GLU A O    1 
ATOM   2438 C CB   . GLU B  1 55  ? 138.643 129.980 86.212  1.00 95.64  ? 55  GLU A CB   1 
ATOM   2439 C CG   . GLU B  1 55  ? 139.395 129.574 84.960  1.00 96.68  ? 55  GLU A CG   1 
ATOM   2440 C CD   . GLU B  1 55  ? 139.529 130.713 83.971  1.00 103.02 ? 55  GLU A CD   1 
ATOM   2441 O OE1  . GLU B  1 55  ? 139.493 131.884 84.404  1.00 104.83 ? 55  GLU A OE1  1 
ATOM   2442 O OE2  . GLU B  1 55  ? 139.664 130.440 82.758  1.00 104.21 ? 55  GLU A OE2  1 
ATOM   2443 N N    . ARG B  1 56  ? 136.019 128.204 86.283  1.00 95.96  ? 56  ARG A N    1 
ATOM   2444 C CA   . ARG B  1 56  ? 135.283 127.034 85.811  1.00 90.82  ? 56  ARG A CA   1 
ATOM   2445 C C    . ARG B  1 56  ? 133.958 127.429 85.170  1.00 90.38  ? 56  ARG A C    1 
ATOM   2446 O O    . ARG B  1 56  ? 133.585 126.900 84.113  1.00 90.40  ? 56  ARG A O    1 
ATOM   2447 C CB   . ARG B  1 56  ? 135.047 126.056 86.960  1.00 87.91  ? 56  ARG A CB   1 
ATOM   2448 C CG   . ARG B  1 56  ? 136.258 125.228 87.339  1.00 89.87  ? 56  ARG A CG   1 
ATOM   2449 C CD   . ARG B  1 56  ? 135.958 124.340 88.529  1.00 88.84  ? 56  ARG A CD   1 
ATOM   2450 N NE   . ARG B  1 56  ? 137.095 123.504 88.884  1.00 90.15  ? 56  ARG A NE   1 
ATOM   2451 C CZ   . ARG B  1 56  ? 137.151 122.739 89.968  1.00 92.18  ? 56  ARG A CZ   1 
ATOM   2452 N NH1  . ARG B  1 56  ? 136.148 122.692 90.829  1.00 94.05  ? 56  ARG A NH1  1 
ATOM   2453 N NH2  . ARG B  1 56  ? 138.239 122.011 90.191  1.00 94.53  ? 56  ARG A NH2  1 
ATOM   2454 N N    . LEU B  1 57  ? 133.231 128.354 85.798  1.00 86.92  ? 57  LEU A N    1 
ATOM   2455 C CA   . LEU B  1 57  ? 131.957 128.787 85.229  1.00 83.34  ? 57  LEU A CA   1 
ATOM   2456 C C    . LEU B  1 57  ? 132.150 129.440 83.869  1.00 87.01  ? 57  LEU A C    1 
ATOM   2457 O O    . LEU B  1 57  ? 131.391 129.173 82.929  1.00 85.40  ? 57  LEU A O    1 
ATOM   2458 C CB   . LEU B  1 57  ? 131.253 129.751 86.185  1.00 81.76  ? 57  LEU A CB   1 
ATOM   2459 C CG   . LEU B  1 57  ? 130.006 130.437 85.621  1.00 79.57  ? 57  LEU A CG   1 
ATOM   2460 C CD1  . LEU B  1 57  ? 128.949 129.413 85.262  1.00 81.49  ? 57  LEU A CD1  1 
ATOM   2461 C CD2  . LEU B  1 57  ? 129.459 131.454 86.603  1.00 83.76  ? 57  LEU A CD2  1 
ATOM   2462 N N    . ALA B  1 58  ? 133.164 130.300 83.742  1.00 97.09  ? 58  ALA A N    1 
ATOM   2463 C CA   . ALA B  1 58  ? 133.416 130.934 82.452  1.00 92.48  ? 58  ALA A CA   1 
ATOM   2464 C C    . ALA B  1 58  ? 133.742 129.899 81.386  1.00 92.21  ? 58  ALA A C    1 
ATOM   2465 O O    . ALA B  1 58  ? 133.246 129.981 80.255  1.00 90.35  ? 58  ALA A O    1 
ATOM   2466 C CB   . ALA B  1 58  ? 134.547 131.952 82.577  1.00 94.77  ? 58  ALA A CB   1 
ATOM   2467 N N    . GLN B  1 59  ? 134.568 128.908 81.727  1.00 102.42 ? 59  GLN A N    1 
ATOM   2468 C CA   . GLN B  1 59  ? 134.926 127.884 80.751  1.00 102.80 ? 59  GLN A CA   1 
ATOM   2469 C C    . GLN B  1 59  ? 133.698 127.101 80.304  1.00 102.56 ? 59  GLN A C    1 
ATOM   2470 O O    . GLN B  1 59  ? 133.499 126.865 79.106  1.00 101.09 ? 59  GLN A O    1 
ATOM   2471 C CB   . GLN B  1 59  ? 135.980 126.945 81.338  1.00 103.93 ? 59  GLN A CB   1 
ATOM   2472 C CG   . GLN B  1 59  ? 136.856 126.270 80.297  1.00 105.28 ? 59  GLN A CG   1 
ATOM   2473 C CD   . GLN B  1 59  ? 136.138 125.154 79.567  1.00 107.80 ? 59  GLN A CD   1 
ATOM   2474 O OE1  . GLN B  1 59  ? 135.193 124.564 80.087  1.00 107.23 ? 59  GLN A OE1  1 
ATOM   2475 N NE2  . GLN B  1 59  ? 136.585 124.863 78.350  1.00 106.79 ? 59  GLN A NE2  1 
ATOM   2476 N N    . PHE B  1 60  ? 132.852 126.702 81.257  1.00 99.43  ? 60  PHE A N    1 
ATOM   2477 C CA   . PHE B  1 60  ? 131.654 125.943 80.899  1.00 96.79  ? 60  PHE A CA   1 
ATOM   2478 C C    . PHE B  1 60  ? 130.731 126.768 80.012  1.00 95.66  ? 60  PHE A C    1 
ATOM   2479 O O    . PHE B  1 60  ? 130.213 126.270 79.007  1.00 92.07  ? 60  PHE A O    1 
ATOM   2480 C CB   . PHE B  1 60  ? 130.921 125.489 82.163  1.00 96.69  ? 60  PHE A CB   1 
ATOM   2481 C CG   . PHE B  1 60  ? 129.711 124.638 81.887  1.00 94.77  ? 60  PHE A CG   1 
ATOM   2482 C CD1  . PHE B  1 60  ? 129.832 123.271 81.715  1.00 94.01  ? 60  PHE A CD1  1 
ATOM   2483 C CD2  . PHE B  1 60  ? 128.452 125.206 81.802  1.00 95.09  ? 60  PHE A CD2  1 
ATOM   2484 C CE1  . PHE B  1 60  ? 128.722 122.491 81.467  1.00 90.93  ? 60  PHE A CE1  1 
ATOM   2485 C CE2  . PHE B  1 60  ? 127.339 124.429 81.553  1.00 90.23  ? 60  PHE A CE2  1 
ATOM   2486 C CZ   . PHE B  1 60  ? 127.476 123.068 81.385  1.00 87.98  ? 60  PHE A CZ   1 
ATOM   2487 N N    . SER B  1 61  ? 130.513 128.036 80.369  1.00 107.26 ? 61  SER A N    1 
ATOM   2488 C CA   . SER B  1 61  ? 129.616 128.873 79.580  1.00 105.13 ? 61  SER A CA   1 
ATOM   2489 C C    . SER B  1 61  ? 130.143 129.073 78.166  1.00 103.81 ? 61  SER A C    1 
ATOM   2490 O O    . SER B  1 61  ? 129.379 129.022 77.196  1.00 101.08 ? 61  SER A O    1 
ATOM   2491 C CB   . SER B  1 61  ? 129.412 130.221 80.266  1.00 106.42 ? 61  SER A CB   1 
ATOM   2492 O OG   . SER B  1 61  ? 128.627 131.082 79.464  1.00 106.72 ? 61  SER A OG   1 
ATOM   2493 N N    . ARG B  1 62  ? 131.451 129.308 78.023  1.00 113.18 ? 62  ARG A N    1 
ATOM   2494 C CA   . ARG B  1 62  ? 132.027 129.475 76.691  1.00 113.54 ? 62  ARG A CA   1 
ATOM   2495 C C    . ARG B  1 62  ? 131.939 128.191 75.873  1.00 111.44 ? 62  ARG A C    1 
ATOM   2496 O O    . ARG B  1 62  ? 131.691 128.241 74.664  1.00 109.21 ? 62  ARG A O    1 
ATOM   2497 C CB   . ARG B  1 62  ? 133.477 129.942 76.795  1.00 113.86 ? 62  ARG A CB   1 
ATOM   2498 C CG   . ARG B  1 62  ? 134.160 130.083 75.445  1.00 112.69 ? 62  ARG A CG   1 
ATOM   2499 C CD   . ARG B  1 62  ? 135.515 130.764 75.558  1.00 113.74 ? 62  ARG A CD   1 
ATOM   2500 N NE   . ARG B  1 62  ? 136.427 130.044 76.438  1.00 114.63 ? 62  ARG A NE   1 
ATOM   2501 C CZ   . ARG B  1 62  ? 136.732 130.426 77.670  1.00 114.32 ? 62  ARG A CZ   1 
ATOM   2502 N NH1  . ARG B  1 62  ? 136.218 131.523 78.200  1.00 112.72 ? 62  ARG A NH1  1 
ATOM   2503 N NH2  . ARG B  1 62  ? 137.576 129.692 78.388  1.00 112.26 ? 62  ARG A NH2  1 
ATOM   2504 N N    . GLY B  1 63  ? 132.136 127.036 76.507  1.00 112.43 ? 63  GLY A N    1 
ATOM   2505 C CA   . GLY B  1 63  ? 132.168 125.795 75.749  1.00 113.71 ? 63  GLY A CA   1 
ATOM   2506 C C    . GLY B  1 63  ? 130.844 125.439 75.098  1.00 112.96 ? 63  GLY A C    1 
ATOM   2507 O O    . GLY B  1 63  ? 130.814 125.019 73.938  1.00 111.29 ? 63  GLY A O    1 
ATOM   2508 N N    . HIS B  1 64  ? 129.736 125.595 75.821  1.00 118.14 ? 64  HIS A N    1 
ATOM   2509 C CA   . HIS B  1 64  ? 128.430 125.168 75.336  1.00 117.95 ? 64  HIS A CA   1 
ATOM   2510 C C    . HIS B  1 64  ? 127.588 126.325 74.806  1.00 118.04 ? 64  HIS A C    1 
ATOM   2511 O O    . HIS B  1 64  ? 126.363 126.199 74.710  1.00 114.75 ? 64  HIS A O    1 
ATOM   2512 C CB   . HIS B  1 64  ? 127.676 124.419 76.433  1.00 115.26 ? 64  HIS A CB   1 
ATOM   2513 C CG   . HIS B  1 64  ? 128.241 123.066 76.732  1.00 114.65 ? 64  HIS A CG   1 
ATOM   2514 N ND1  . HIS B  1 64  ? 129.333 122.882 77.551  1.00 117.66 ? 64  HIS A ND1  1 
ATOM   2515 C CD2  . HIS B  1 64  ? 127.871 121.834 76.312  1.00 114.68 ? 64  HIS A CD2  1 
ATOM   2516 C CE1  . HIS B  1 64  ? 129.607 121.592 77.628  1.00 117.03 ? 64  HIS A CE1  1 
ATOM   2517 N NE2  . HIS B  1 64  ? 128.737 120.934 76.886  1.00 118.65 ? 64  HIS A NE2  1 
ATOM   2518 N N    . GLN B  1 65  ? 128.223 127.445 74.456  1.00 123.64 ? 65  GLN A N    1 
ATOM   2519 C CA   . GLN B  1 65  ? 127.560 128.576 73.811  1.00 121.97 ? 65  GLN A CA   1 
ATOM   2520 C C    . GLN B  1 65  ? 126.218 128.924 74.446  1.00 119.04 ? 65  GLN A C    1 
ATOM   2521 O O    . GLN B  1 65  ? 125.283 129.319 73.747  1.00 115.85 ? 65  GLN A O    1 
ATOM   2522 C CB   . GLN B  1 65  ? 127.376 128.298 72.317  1.00 120.15 ? 65  GLN A CB   1 
ATOM   2523 C CG   . GLN B  1 65  ? 126.434 127.151 72.000  1.00 119.52 ? 65  GLN A CG   1 
ATOM   2524 C CD   . GLN B  1 65  ? 126.383 126.837 70.520  1.00 122.45 ? 65  GLN A CD   1 
ATOM   2525 O OE1  . GLN B  1 65  ? 127.043 127.493 69.712  1.00 122.50 ? 65  GLN A OE1  1 
ATOM   2526 N NE2  . GLN B  1 65  ? 125.598 125.830 70.157  1.00 121.83 ? 65  GLN A NE2  1 
ATOM   2527 N N    . LEU B  1 66  ? 126.111 128.775 75.762  1.00 115.72 ? 66  LEU A N    1 
ATOM   2528 C CA   . LEU B  1 66  ? 124.916 129.190 76.481  1.00 113.74 ? 66  LEU A CA   1 
ATOM   2529 C C    . LEU B  1 66  ? 125.002 130.668 76.845  1.00 114.54 ? 66  LEU A C    1 
ATOM   2530 O O    . LEU B  1 66  ? 126.030 131.323 76.665  1.00 116.56 ? 66  LEU A O    1 
ATOM   2531 C CB   . LEU B  1 66  ? 124.721 128.346 77.741  1.00 110.62 ? 66  LEU A CB   1 
ATOM   2532 C CG   . LEU B  1 66  ? 124.384 126.867 77.560  1.00 111.51 ? 66  LEU A CG   1 
ATOM   2533 C CD1  . LEU B  1 66  ? 124.788 126.081 78.794  1.00 113.08 ? 66  LEU A CD1  1 
ATOM   2534 C CD2  . LEU B  1 66  ? 122.905 126.690 77.279  1.00 113.31 ? 66  LEU A CD2  1 
ATOM   2535 N N    . SER B  1 67  ? 123.899 131.195 77.366  1.00 117.42 ? 67  SER A N    1 
ATOM   2536 C CA   . SER B  1 67  ? 123.864 132.555 77.878  1.00 117.24 ? 67  SER A CA   1 
ATOM   2537 C C    . SER B  1 67  ? 124.353 132.560 79.325  1.00 118.82 ? 67  SER A C    1 
ATOM   2538 O O    . SER B  1 67  ? 124.892 131.571 79.824  1.00 120.19 ? 67  SER A O    1 
ATOM   2539 C CB   . SER B  1 67  ? 122.457 133.135 77.743  1.00 117.71 ? 67  SER A CB   1 
ATOM   2540 O OG   . SER B  1 67  ? 122.395 134.443 78.283  1.00 117.55 ? 67  SER A OG   1 
ATOM   2541 N N    . ARG B  1 68  ? 124.171 133.685 80.018  1.00 119.84 ? 68  ARG A N    1 
ATOM   2542 C CA   . ARG B  1 68  ? 124.543 133.788 81.422  1.00 119.65 ? 68  ARG A CA   1 
ATOM   2543 C C    . ARG B  1 68  ? 123.354 133.800 82.368  1.00 119.09 ? 68  ARG A C    1 
ATOM   2544 O O    . ARG B  1 68  ? 123.482 133.319 83.497  1.00 118.66 ? 68  ARG A O    1 
ATOM   2545 C CB   . ARG B  1 68  ? 125.377 135.053 81.659  1.00 120.20 ? 68  ARG A CB   1 
ATOM   2546 C CG   . ARG B  1 68  ? 125.994 135.133 83.043  1.00 121.07 ? 68  ARG A CG   1 
ATOM   2547 C CD   . ARG B  1 68  ? 126.928 133.962 83.299  1.00 120.78 ? 68  ARG A CD   1 
ATOM   2548 N NE   . ARG B  1 68  ? 128.146 134.046 82.505  1.00 120.22 ? 68  ARG A NE   1 
ATOM   2549 C CZ   . ARG B  1 68  ? 129.275 134.598 82.926  1.00 119.75 ? 68  ARG A CZ   1 
ATOM   2550 N NH1  . ARG B  1 68  ? 129.381 135.122 84.137  1.00 120.25 ? 68  ARG A NH1  1 
ATOM   2551 N NH2  . ARG B  1 68  ? 130.330 134.620 82.115  1.00 116.98 ? 68  ARG A NH2  1 
ATOM   2552 N N    . ASP B  1 69  ? 122.207 134.330 81.945  1.00 119.96 ? 69  ASP A N    1 
ATOM   2553 C CA   . ASP B  1 69  ? 121.039 134.368 82.822  1.00 119.86 ? 69  ASP A CA   1 
ATOM   2554 C C    . ASP B  1 69  ? 120.397 132.990 82.943  1.00 121.61 ? 69  ASP A C    1 
ATOM   2555 O O    . ASP B  1 69  ? 119.885 132.629 84.012  1.00 122.75 ? 69  ASP A O    1 
ATOM   2556 C CB   . ASP B  1 69  ? 120.026 135.387 82.311  1.00 121.57 ? 69  ASP A CB   1 
ATOM   2557 C CG   . ASP B  1 69  ? 120.562 136.804 82.334  1.00 125.39 ? 69  ASP A CG   1 
ATOM   2558 O OD1  . ASP B  1 69  ? 121.490 137.073 83.125  1.00 125.14 ? 69  ASP A OD1  1 
ATOM   2559 O OD2  . ASP B  1 69  ? 120.055 137.648 81.567  1.00 126.26 ? 69  ASP A OD2  1 
ATOM   2560 N N    . GLU B  1 70  ? 120.408 132.213 81.861  1.00 112.37 ? 70  GLU A N    1 
ATOM   2561 C CA   . GLU B  1 70  ? 119.775 130.900 81.895  1.00 111.19 ? 70  GLU A CA   1 
ATOM   2562 C C    . GLU B  1 70  ? 120.465 129.991 82.901  1.00 112.68 ? 70  GLU A C    1 
ATOM   2563 O O    . GLU B  1 70  ? 119.805 129.251 83.639  1.00 111.40 ? 70  GLU A O    1 
ATOM   2564 C CB   . GLU B  1 70  ? 119.788 130.280 80.501  1.00 109.86 ? 70  GLU A CB   1 
ATOM   2565 C CG   . GLU B  1 70  ? 119.185 131.175 79.436  1.00 111.79 ? 70  GLU A CG   1 
ATOM   2566 C CD   . GLU B  1 70  ? 119.176 130.530 78.067  1.00 113.21 ? 70  GLU A CD   1 
ATOM   2567 O OE1  . GLU B  1 70  ? 119.567 129.348 77.963  1.00 116.63 ? 70  GLU A OE1  1 
ATOM   2568 O OE2  . GLU B  1 70  ? 118.778 131.201 77.092  1.00 112.24 ? 70  GLU A OE2  1 
ATOM   2569 N N    . LEU B  1 71  ? 121.799 130.023 82.937  1.00 100.24 ? 71  LEU A N    1 
ATOM   2570 C CA   . LEU B  1 71  ? 122.516 129.252 83.944  1.00 96.53  ? 71  LEU A CA   1 
ATOM   2571 C C    . LEU B  1 71  ? 122.185 129.737 85.349  1.00 96.68  ? 71  LEU A C    1 
ATOM   2572 O O    . LEU B  1 71  ? 122.129 128.933 86.282  1.00 98.80  ? 71  LEU A O    1 
ATOM   2573 C CB   . LEU B  1 71  ? 124.020 129.325 83.690  1.00 92.83  ? 71  LEU A CB   1 
ATOM   2574 C CG   . LEU B  1 71  ? 124.512 128.594 82.443  1.00 92.90  ? 71  LEU A CG   1 
ATOM   2575 C CD1  . LEU B  1 71  ? 125.990 128.849 82.222  1.00 94.83  ? 71  LEU A CD1  1 
ATOM   2576 C CD2  . LEU B  1 71  ? 124.243 127.107 82.563  1.00 94.96  ? 71  LEU A CD2  1 
ATOM   2577 N N    . ARG B  1 72  ? 121.951 131.039 85.518  1.00 99.80  ? 72  ARG A N    1 
ATOM   2578 C CA   . ARG B  1 72  ? 121.544 131.540 86.827  1.00 99.17  ? 72  ARG A CA   1 
ATOM   2579 C C    . ARG B  1 72  ? 120.193 130.974 87.240  1.00 102.75 ? 72  ARG A C    1 
ATOM   2580 O O    . ARG B  1 72  ? 120.008 130.574 88.394  1.00 108.61 ? 72  ARG A O    1 
ATOM   2581 C CB   . ARG B  1 72  ? 121.502 133.068 86.825  1.00 102.27 ? 72  ARG A CB   1 
ATOM   2582 C CG   . ARG B  1 72  ? 122.856 133.732 86.630  1.00 106.38 ? 72  ARG A CG   1 
ATOM   2583 C CD   . ARG B  1 72  ? 123.035 134.903 87.584  1.00 105.62 ? 72  ARG A CD   1 
ATOM   2584 N NE   . ARG B  1 72  ? 121.900 135.821 87.541  1.00 108.11 ? 72  ARG A NE   1 
ATOM   2585 C CZ   . ARG B  1 72  ? 121.813 136.871 86.738  1.00 109.32 ? 72  ARG A CZ   1 
ATOM   2586 N NH1  . ARG B  1 72  ? 122.784 137.178 85.894  1.00 108.31 ? 72  ARG A NH1  1 
ATOM   2587 N NH2  . ARG B  1 72  ? 120.726 137.637 86.788  1.00 106.99 ? 72  ARG A NH2  1 
ATOM   2588 N N    . GLY B  1 73  ? 119.238 130.922 86.311  1.00 92.44  ? 73  GLY A N    1 
ATOM   2589 C CA   . GLY B  1 73  ? 117.951 130.328 86.633  1.00 93.21  ? 73  GLY A CA   1 
ATOM   2590 C C    . GLY B  1 73  ? 118.057 128.847 86.940  1.00 94.72  ? 73  GLY A C    1 
ATOM   2591 O O    . GLY B  1 73  ? 117.409 128.344 87.866  1.00 97.52  ? 73  GLY A O    1 
ATOM   2592 N N    . PHE B  1 74  ? 118.882 128.132 86.174  1.00 75.35  ? 74  PHE A N    1 
ATOM   2593 C CA   . PHE B  1 74  ? 119.102 126.717 86.443  1.00 70.15  ? 74  PHE A CA   1 
ATOM   2594 C C    . PHE B  1 74  ? 119.692 126.509 87.835  1.00 72.10  ? 74  PHE A C    1 
ATOM   2595 O O    . PHE B  1 74  ? 119.249 125.629 88.585  1.00 76.12  ? 74  PHE A O    1 
ATOM   2596 C CB   . PHE B  1 74  ? 120.016 126.130 85.368  1.00 67.24  ? 74  PHE A CB   1 
ATOM   2597 C CG   . PHE B  1 74  ? 120.169 124.639 85.439  1.00 69.16  ? 74  PHE A CG   1 
ATOM   2598 C CD1  . PHE B  1 74  ? 119.098 123.807 85.180  1.00 69.66  ? 74  PHE A CD1  1 
ATOM   2599 C CD2  . PHE B  1 74  ? 121.393 124.071 85.744  1.00 71.81  ? 74  PHE A CD2  1 
ATOM   2600 C CE1  . PHE B  1 74  ? 119.243 122.438 85.238  1.00 71.63  ? 74  PHE A CE1  1 
ATOM   2601 C CE2  . PHE B  1 74  ? 121.540 122.703 85.800  1.00 70.28  ? 74  PHE A CE2  1 
ATOM   2602 C CZ   . PHE B  1 74  ? 120.463 121.885 85.547  1.00 70.78  ? 74  PHE A CZ   1 
ATOM   2603 N N    . LEU B  1 75  ? 120.680 127.325 88.207  1.00 68.52  ? 75  LEU A N    1 
ATOM   2604 C CA   . LEU B  1 75  ? 121.288 127.195 89.522  1.00 68.00  ? 75  LEU A CA   1 
ATOM   2605 C C    . LEU B  1 75  ? 120.319 127.580 90.635  1.00 73.88  ? 75  LEU A C    1 
ATOM   2606 O O    . LEU B  1 75  ? 120.369 127.000 91.722  1.00 78.14  ? 75  LEU A O    1 
ATOM   2607 C CB   . LEU B  1 75  ? 122.553 128.048 89.597  1.00 69.05  ? 75  LEU A CB   1 
ATOM   2608 C CG   . LEU B  1 75  ? 123.706 127.602 88.693  1.00 69.92  ? 75  LEU A CG   1 
ATOM   2609 C CD1  . LEU B  1 75  ? 124.910 128.507 88.872  1.00 70.19  ? 75  LEU A CD1  1 
ATOM   2610 C CD2  . LEU B  1 75  ? 124.075 126.157 88.964  1.00 71.43  ? 75  LEU A CD2  1 
ATOM   2611 N N    . ARG B  1 76  ? 119.433 128.546 90.387  1.00 78.52  ? 76  ARG A N    1 
ATOM   2612 C CA   . ARG B  1 76  ? 118.423 128.886 91.385  1.00 75.96  ? 76  ARG A CA   1 
ATOM   2613 C C    . ARG B  1 76  ? 117.455 127.728 91.602  1.00 78.88  ? 76  ARG A C    1 
ATOM   2614 O O    . ARG B  1 76  ? 117.101 127.403 92.746  1.00 79.61  ? 76  ARG A O    1 
ATOM   2615 C CB   . ARG B  1 76  ? 117.669 130.144 90.958  1.00 73.41  ? 76  ARG A CB   1 
ATOM   2616 C CG   . ARG B  1 76  ? 116.791 130.741 92.038  1.00 80.85  ? 76  ARG A CG   1 
ATOM   2617 C CD   . ARG B  1 76  ? 115.945 131.878 91.490  1.00 84.45  ? 76  ARG A CD   1 
ATOM   2618 N NE   . ARG B  1 76  ? 116.752 132.898 90.830  1.00 79.88  ? 76  ARG A NE   1 
ATOM   2619 C CZ   . ARG B  1 76  ? 117.278 133.949 91.445  1.00 82.78  ? 76  ARG A CZ   1 
ATOM   2620 N NH1  . ARG B  1 76  ? 117.107 134.150 92.740  1.00 82.68  ? 76  ARG A NH1  1 
ATOM   2621 N NH2  . ARG B  1 76  ? 117.992 134.821 90.739  1.00 81.76  ? 76  ARG A NH2  1 
ATOM   2622 N N    . HIS B  1 77  ? 117.024 127.086 90.514  1.00 76.08  ? 77  HIS A N    1 
ATOM   2623 C CA   . HIS B  1 77  ? 116.183 125.900 90.647  1.00 71.35  ? 77  HIS A CA   1 
ATOM   2624 C C    . HIS B  1 77  ? 116.904 124.803 91.416  1.00 75.35  ? 77  HIS A C    1 
ATOM   2625 O O    . HIS B  1 77  ? 116.303 124.126 92.259  1.00 77.01  ? 77  HIS A O    1 
ATOM   2626 C CB   . HIS B  1 77  ? 115.760 125.393 89.270  1.00 73.13  ? 77  HIS A CB   1 
ATOM   2627 C CG   . HIS B  1 77  ? 114.739 126.255 88.594  1.00 77.68  ? 77  HIS A CG   1 
ATOM   2628 N ND1  . HIS B  1 77  ? 114.376 126.079 87.277  1.00 78.57  ? 77  HIS A ND1  1 
ATOM   2629 C CD2  . HIS B  1 77  ? 114.000 127.288 89.052  1.00 79.19  ? 77  HIS A CD2  1 
ATOM   2630 C CE1  . HIS B  1 77  ? 113.457 126.969 86.952  1.00 78.13  ? 77  HIS A CE1  1 
ATOM   2631 N NE2  . HIS B  1 77  ? 113.212 127.719 88.012  1.00 81.23  ? 77  HIS A NE2  1 
ATOM   2632 N N    . TYR B  1 78  ? 118.195 124.604 91.137  1.00 77.01  ? 78  TYR A N    1 
ATOM   2633 C CA   . TYR B  1 78  ? 118.937 123.575 91.859  1.00 72.05  ? 78  TYR A CA   1 
ATOM   2634 C C    . TYR B  1 78  ? 119.086 123.917 93.335  1.00 71.67  ? 78  TYR A C    1 
ATOM   2635 O O    . TYR B  1 78  ? 119.062 123.025 94.188  1.00 78.93  ? 78  TYR A O    1 
ATOM   2636 C CB   . TYR B  1 78  ? 120.307 123.362 91.221  1.00 72.36  ? 78  TYR A CB   1 
ATOM   2637 C CG   . TYR B  1 78  ? 121.107 122.272 91.894  1.00 69.64  ? 78  TYR A CG   1 
ATOM   2638 C CD1  . TYR B  1 78  ? 120.721 120.946 91.801  1.00 70.18  ? 78  TYR A CD1  1 
ATOM   2639 C CD2  . TYR B  1 78  ? 122.248 122.573 92.622  1.00 69.78  ? 78  TYR A CD2  1 
ATOM   2640 C CE1  . TYR B  1 78  ? 121.447 119.950 92.413  1.00 69.60  ? 78  TYR A CE1  1 
ATOM   2641 C CE2  . TYR B  1 78  ? 122.979 121.581 93.238  1.00 73.10  ? 78  TYR A CE2  1 
ATOM   2642 C CZ   . TYR B  1 78  ? 122.574 120.272 93.129  1.00 74.54  ? 78  TYR A CZ   1 
ATOM   2643 O OH   . TYR B  1 78  ? 123.299 119.279 93.742  1.00 81.03  ? 78  TYR A OH   1 
ATOM   2644 N N    . GLU B  1 79  ? 119.243 125.200 93.663  1.00 77.78  ? 79  GLU A N    1 
ATOM   2645 C CA   . GLU B  1 79  ? 119.307 125.591 95.068  1.00 78.68  ? 79  GLU A CA   1 
ATOM   2646 C C    . GLU B  1 79  ? 117.989 125.309 95.773  1.00 82.32  ? 79  GLU A C    1 
ATOM   2647 O O    . GLU B  1 79  ? 117.977 124.803 96.903  1.00 83.46  ? 79  GLU A O    1 
ATOM   2648 C CB   . GLU B  1 79  ? 119.665 127.072 95.187  1.00 82.13  ? 79  GLU A CB   1 
ATOM   2649 C CG   . GLU B  1 79  ? 121.123 127.391 94.920  1.00 86.05  ? 79  GLU A CG   1 
ATOM   2650 C CD   . GLU B  1 79  ? 121.498 128.792 95.354  1.00 89.61  ? 79  GLU A CD   1 
ATOM   2651 O OE1  . GLU B  1 79  ? 120.618 129.503 95.885  1.00 90.25  ? 79  GLU A OE1  1 
ATOM   2652 O OE2  . GLU B  1 79  ? 122.666 129.182 95.163  1.00 93.17  ? 79  GLU A OE2  1 
ATOM   2653 N N    . GLU B  1 80  ? 116.870 125.604 95.111  1.00 86.37  ? 80  GLU A N    1 
ATOM   2654 C CA   . GLU B  1 80  ? 115.574 125.267 95.695  1.00 80.68  ? 80  GLU A CA   1 
ATOM   2655 C C    . GLU B  1 80  ? 115.435 123.764 95.894  1.00 79.63  ? 80  GLU A C    1 
ATOM   2656 O O    . GLU B  1 80  ? 114.945 123.311 96.934  1.00 75.50  ? 80  GLU A O    1 
ATOM   2657 C CB   . GLU B  1 80  ? 114.445 125.802 94.816  1.00 79.43  ? 80  GLU A CB   1 
ATOM   2658 C CG   . GLU B  1 80  ? 113.060 125.465 95.327  1.00 82.02  ? 80  GLU A CG   1 
ATOM   2659 C CD   . GLU B  1 80  ? 111.965 126.099 94.495  1.00 87.89  ? 80  GLU A CD   1 
ATOM   2660 O OE1  . GLU B  1 80  ? 112.195 127.196 93.945  1.00 89.30  ? 80  GLU A OE1  1 
ATOM   2661 O OE2  . GLU B  1 80  ? 110.877 125.496 94.390  1.00 89.23  ? 80  GLU A OE2  1 
ATOM   2662 N N    . ALA B  1 81  ? 115.859 122.975 94.905  1.00 79.89  ? 81  ALA A N    1 
ATOM   2663 C CA   . ALA B  1 81  ? 115.762 121.523 95.021  1.00 72.00  ? 81  ALA A CA   1 
ATOM   2664 C C    . ALA B  1 81  ? 116.624 120.995 96.161  1.00 71.88  ? 81  ALA A C    1 
ATOM   2665 O O    . ALA B  1 81  ? 116.203 120.104 96.905  1.00 77.29  ? 81  ALA A O    1 
ATOM   2666 C CB   . ALA B  1 81  ? 116.161 120.865 93.701  1.00 75.07  ? 81  ALA A CB   1 
ATOM   2667 N N    . THR B  1 82  ? 117.834 121.535 96.316  1.00 82.96  ? 82  THR A N    1 
ATOM   2668 C CA   . THR B  1 82  ? 118.731 121.087 97.376  1.00 83.10  ? 82  THR A CA   1 
ATOM   2669 C C    . THR B  1 82  ? 118.302 121.580 98.749  1.00 85.17  ? 82  THR A C    1 
ATOM   2670 O O    . THR B  1 82  ? 118.718 120.996 99.755  1.00 85.37  ? 82  THR A O    1 
ATOM   2671 C CB   . THR B  1 82  ? 120.159 121.551 97.095  1.00 82.81  ? 82  THR A CB   1 
ATOM   2672 O OG1  . THR B  1 82  ? 121.083 120.661 97.726  1.00 88.88  ? 82  THR A OG1  1 
ATOM   2673 C CG2  . THR B  1 82  ? 120.376 122.950 97.640  1.00 83.20  ? 82  THR A CG2  1 
ATOM   2674 N N    . ARG B  1 83  ? 117.476 122.625 98.821  1.00 89.43  ? 83  ARG A N    1 
ATOM   2675 C CA   . ARG B  1 83  ? 116.860 122.956 100.099 1.00 84.89  ? 83  ARG A CA   1 
ATOM   2676 C C    . ARG B  1 83  ? 115.899 121.864 100.550 1.00 82.35  ? 83  ARG A C    1 
ATOM   2677 O O    . ARG B  1 83  ? 115.722 121.654 101.755 1.00 83.53  ? 83  ARG A O    1 
ATOM   2678 C CB   . ARG B  1 83  ? 116.136 124.299 100.008 1.00 88.53  ? 83  ARG A CB   1 
ATOM   2679 C CG   . ARG B  1 83  ? 115.878 124.954 101.353 1.00 84.53  ? 83  ARG A CG   1 
ATOM   2680 C CD   . ARG B  1 83  ? 115.222 126.315 101.189 1.00 87.36  ? 83  ARG A CD   1 
ATOM   2681 N NE   . ARG B  1 83  ? 116.057 127.242 100.436 1.00 93.18  ? 83  ARG A NE   1 
ATOM   2682 C CZ   . ARG B  1 83  ? 115.636 127.959 99.405  1.00 92.43  ? 83  ARG A CZ   1 
ATOM   2683 N NH1  . ARG B  1 83  ? 114.384 127.893 98.981  1.00 89.02  ? 83  ARG A NH1  1 
ATOM   2684 N NH2  . ARG B  1 83  ? 116.491 128.766 98.782  1.00 89.08  ? 83  ARG A NH2  1 
ATOM   2685 N N    . ALA B  1 84  ? 115.277 121.163 99.609  1.00 85.80  ? 84  ALA A N    1 
ATOM   2686 C CA   . ALA B  1 84  ? 114.601 119.919 99.906  1.00 79.15  ? 84  ALA A CA   1 
ATOM   2687 C C    . ALA B  1 84  ? 115.639 118.805 100.010 1.00 81.63  ? 84  ALA A C    1 
ATOM   2688 O O    . ALA B  1 84  ? 116.847 119.059 100.049 1.00 83.97  ? 84  ALA A O    1 
ATOM   2689 C CB   . ALA B  1 84  ? 113.558 119.604 98.826  1.00 79.62  ? 84  ALA A CB   1 
ATOM   2690 N N    . GLY B  1 85  ? 115.197 117.564 100.064 1.00 75.12  ? 85  GLY A N    1 
ATOM   2691 C CA   . GLY B  1 85  ? 116.095 116.454 100.305 1.00 78.39  ? 85  GLY A CA   1 
ATOM   2692 C C    . GLY B  1 85  ? 116.731 115.854 99.065  1.00 82.22  ? 85  GLY A C    1 
ATOM   2693 O O    . GLY B  1 85  ? 116.810 114.629 98.936  1.00 86.55  ? 85  GLY A O    1 
ATOM   2694 N N    . ILE B  1 86  ? 117.204 116.699 98.152  1.00 77.15  ? 86  ILE A N    1 
ATOM   2695 C CA   . ILE B  1 86  ? 117.784 116.257 96.890  1.00 74.20  ? 86  ILE A CA   1 
ATOM   2696 C C    . ILE B  1 86  ? 119.274 116.558 96.915  1.00 77.15  ? 86  ILE A C    1 
ATOM   2697 O O    . ILE B  1 86  ? 119.682 117.688 97.196  1.00 83.45  ? 86  ILE A O    1 
ATOM   2698 C CB   . ILE B  1 86  ? 117.111 116.933 95.684  1.00 69.90  ? 86  ILE A CB   1 
ATOM   2699 C CG1  . ILE B  1 86  ? 115.732 116.326 95.429  1.00 75.41  ? 86  ILE A CG1  1 
ATOM   2700 C CG2  . ILE B  1 86  ? 117.976 116.795 94.448  1.00 69.20  ? 86  ILE A CG2  1 
ATOM   2701 C CD1  . ILE B  1 86  ? 115.782 114.905 94.926  1.00 78.33  ? 86  ILE A CD1  1 
ATOM   2702 N N    . ARG B  1 87  ? 120.081 115.541 96.612  1.00 81.17  ? 87  ARG A N    1 
ATOM   2703 C CA   . ARG B  1 87  ? 121.528 115.696 96.548  1.00 77.42  ? 87  ARG A CA   1 
ATOM   2704 C C    . ARG B  1 87  ? 122.053 115.180 95.216  1.00 79.26  ? 87  ARG A C    1 
ATOM   2705 O O    . ARG B  1 87  ? 121.274 114.896 94.303  1.00 82.79  ? 87  ARG A O    1 
ATOM   2706 C CB   . ARG B  1 87  ? 122.199 114.959 97.705  1.00 79.23  ? 87  ARG A CB   1 
ATOM   2707 C CG   . ARG B  1 87  ? 123.518 115.566 98.143  1.00 80.64  ? 87  ARG A CG   1 
ATOM   2708 C CD   . ARG B  1 87  ? 123.311 116.941 98.751  1.00 79.85  ? 87  ARG A CD   1 
ATOM   2709 N NE   . ARG B  1 87  ? 122.434 116.890 99.914  1.00 78.82  ? 87  ARG A NE   1 
ATOM   2710 C CZ   . ARG B  1 87  ? 122.152 117.931 100.687 1.00 82.21  ? 87  ARG A CZ   1 
ATOM   2711 N NH1  . ARG B  1 87  ? 122.671 119.125 100.451 1.00 82.11  ? 87  ARG A NH1  1 
ATOM   2712 N NH2  . ARG B  1 87  ? 121.334 117.770 101.720 1.00 82.09  ? 87  ARG A NH2  1 
ATOM   2713 N N    . VAL B  1 88  ? 123.373 115.057 95.097  1.00 93.64  ? 88  VAL A N    1 
ATOM   2714 C CA   . VAL B  1 88  ? 123.981 114.609 93.854  1.00 96.26  ? 88  VAL A CA   1 
ATOM   2715 C C    . VAL B  1 88  ? 124.380 113.134 93.881  1.00 98.43  ? 88  VAL A C    1 
ATOM   2716 O O    . VAL B  1 88  ? 124.511 112.524 92.809  1.00 97.21  ? 88  VAL A O    1 
ATOM   2717 C CB   . VAL B  1 88  ? 125.205 115.476 93.493  1.00 96.32  ? 88  VAL A CB   1 
ATOM   2718 C CG1  . VAL B  1 88  ? 126.343 115.211 94.459  1.00 95.36  ? 88  VAL A CG1  1 
ATOM   2719 C CG2  . VAL B  1 88  ? 125.636 115.213 92.061  1.00 93.34  ? 88  VAL A CG2  1 
ATOM   2720 N N    . ASP B  1 89  ? 124.883 112.696 95.027  1.00 107.71 ? 89  ASP A N    1 
ATOM   2721 C CA   . ASP B  1 89  ? 125.449 111.339 95.105  1.00 104.85 ? 89  ASP A CA   1 
ATOM   2722 C C    . ASP B  1 89  ? 124.553 110.387 95.884  1.00 106.47 ? 89  ASP A C    1 
ATOM   2723 O O    . ASP B  1 89  ? 125.059 109.796 96.822  1.00 109.57 ? 89  ASP A O    1 
ATOM   2724 C CB   . ASP B  1 89  ? 126.804 111.429 95.780  1.00 103.72 ? 89  ASP A CB   1 
ATOM   2725 C CG   . ASP B  1 89  ? 127.951 111.442 94.791  1.00 109.84 ? 89  ASP A CG   1 
ATOM   2726 O OD1  . ASP B  1 89  ? 127.764 110.910 93.682  1.00 114.39 ? 89  ASP A OD1  1 
ATOM   2727 O OD2  . ASP B  1 89  ? 129.018 111.983 95.139  1.00 110.33 ? 89  ASP A OD2  1 
ATOM   2728 N N    . ASN B  1 90  ? 123.281 110.242 95.486  1.00 99.56  ? 90  ASN A N    1 
ATOM   2729 C CA   . ASN B  1 90  ? 122.347 109.249 96.098  1.00 100.57 ? 90  ASN A CA   1 
ATOM   2730 C C    . ASN B  1 90  ? 122.096 109.139 97.607  1.00 100.09 ? 90  ASN A C    1 
ATOM   2731 O O    . ASN B  1 90  ? 122.434 108.089 98.191  1.00 101.31 ? 90  ASN A O    1 
ATOM   2732 C CB   . ASN B  1 90  ? 122.647 107.826 95.615  1.00 102.00 ? 90  ASN A CB   1 
ATOM   2733 C CG   . ASN B  1 90  ? 122.267 107.602 94.167  1.00 101.90 ? 90  ASN A CG   1 
ATOM   2734 O OD1  . ASN B  1 90  ? 121.422 108.310 93.625  1.00 103.48 ? 90  ASN A OD1  1 
ATOM   2735 N ND2  . ASN B  1 90  ? 122.882 106.615 93.535  1.00 100.20 ? 90  ASN A ND2  1 
ATOM   2736 N N    . VAL B  1 91  ? 121.515 110.178 98.221  1.00 83.16  ? 91  VAL A N    1 
ATOM   2737 C CA   . VAL B  1 91  ? 121.345 110.178 99.707  1.00 82.56  ? 91  VAL A CA   1 
ATOM   2738 C C    . VAL B  1 91  ? 120.049 109.485 100.143 1.00 84.33  ? 91  VAL A C    1 
ATOM   2739 O O    . VAL B  1 91  ? 119.136 109.360 99.304  1.00 84.64  ? 91  VAL A O    1 
ATOM   2740 C CB   . VAL B  1 91  ? 121.413 111.617 100.253 1.00 79.43  ? 91  VAL A CB   1 
ATOM   2741 C CG1  . VAL B  1 91  ? 122.794 112.226 100.067 1.00 81.18  ? 91  VAL A CG1  1 
ATOM   2742 C CG2  . VAL B  1 91  ? 120.341 112.507 99.645  1.00 83.57  ? 91  VAL A CG2  1 
ATOM   2743 N N    . ARG B  1 92  ? 119.979 109.053 101.407 1.00 79.37  ? 92  ARG A N    1 
ATOM   2744 C CA   . ARG B  1 92  ? 118.783 108.425 101.946 1.00 74.46  ? 92  ARG A CA   1 
ATOM   2745 C C    . ARG B  1 92  ? 117.581 109.370 101.942 1.00 81.14  ? 92  ARG A C    1 
ATOM   2746 O O    . ARG B  1 92  ? 117.739 110.588 102.055 1.00 83.54  ? 92  ARG A O    1 
ATOM   2747 C CB   . ARG B  1 92  ? 119.044 107.934 103.365 1.00 73.09  ? 92  ARG A CB   1 
ATOM   2748 C CG   . ARG B  1 92  ? 119.296 109.051 104.362 1.00 75.66  ? 92  ARG A CG   1 
ATOM   2749 C CD   . ARG B  1 92  ? 119.716 108.522 105.724 1.00 74.86  ? 92  ARG A CD   1 
ATOM   2750 N NE   . ARG B  1 92  ? 118.684 107.714 106.355 1.00 76.71  ? 92  ARG A NE   1 
ATOM   2751 C CZ   . ARG B  1 92  ? 118.756 107.245 107.592 1.00 78.83  ? 92  ARG A CZ   1 
ATOM   2752 N NH1  . ARG B  1 92  ? 119.795 107.499 108.368 1.00 72.75  ? 92  ARG A NH1  1 
ATOM   2753 N NH2  . ARG B  1 92  ? 117.756 106.509 108.067 1.00 78.61  ? 92  ARG A NH2  1 
ATOM   2754 N N    . PRO B  1 93  ? 116.371 108.832 101.816 1.00 77.47  ? 93  PRO A N    1 
ATOM   2755 C CA   . PRO B  1 93  ? 115.182 109.689 101.842 1.00 72.25  ? 93  PRO A CA   1 
ATOM   2756 C C    . PRO B  1 93  ? 114.972 110.315 103.209 1.00 71.81  ? 93  PRO A C    1 
ATOM   2757 O O    . PRO B  1 93  ? 115.350 109.762 104.242 1.00 74.95  ? 93  PRO A O    1 
ATOM   2758 C CB   . PRO B  1 93  ? 114.043 108.724 101.491 1.00 65.31  ? 93  PRO A CB   1 
ATOM   2759 C CG   . PRO B  1 93  ? 114.554 107.387 101.889 1.00 69.18  ? 93  PRO A CG   1 
ATOM   2760 C CD   . PRO B  1 93  ? 116.027 107.417 101.609 1.00 74.95  ? 93  PRO A CD   1 
ATOM   2761 N N    . ARG B  1 94  ? 114.354 111.493 103.201 1.00 72.87  ? 94  ARG A N    1 
ATOM   2762 C CA   . ARG B  1 94  ? 113.972 112.172 104.428 1.00 69.84  ? 94  ARG A CA   1 
ATOM   2763 C C    . ARG B  1 94  ? 112.535 111.832 104.812 1.00 76.69  ? 94  ARG A C    1 
ATOM   2764 O O    . ARG B  1 94  ? 111.704 111.507 103.960 1.00 87.35  ? 94  ARG A O    1 
ATOM   2765 C CB   . ARG B  1 94  ? 114.109 113.688 104.278 1.00 68.86  ? 94  ARG A CB   1 
ATOM   2766 C CG   . ARG B  1 94  ? 115.501 114.231 104.517 1.00 67.73  ? 94  ARG A CG   1 
ATOM   2767 C CD   . ARG B  1 94  ? 116.388 114.078 103.305 1.00 65.69  ? 94  ARG A CD   1 
ATOM   2768 N NE   . ARG B  1 94  ? 117.736 114.561 103.573 1.00 68.23  ? 94  ARG A NE   1 
ATOM   2769 C CZ   . ARG B  1 94  ? 118.719 113.806 104.040 1.00 71.15  ? 94  ARG A CZ   1 
ATOM   2770 N NH1  . ARG B  1 94  ? 118.547 112.518 104.282 1.00 71.96  ? 94  ARG A NH1  1 
ATOM   2771 N NH2  . ARG B  1 94  ? 119.908 114.356 104.268 1.00 74.17  ? 94  ARG A NH2  1 
ATOM   2772 N N    . TRP B  1 95  ? 112.256 111.918 106.107 1.00 56.46  ? 95  TRP A N    1 
ATOM   2773 C CA   . TRP B  1 95  ? 110.887 111.870 106.621 1.00 58.42  ? 95  TRP A CA   1 
ATOM   2774 C C    . TRP B  1 95  ? 110.156 110.576 106.260 1.00 56.64  ? 95  TRP A C    1 
ATOM   2775 O O    . TRP B  1 95  ? 108.982 110.608 105.889 1.00 70.49  ? 95  TRP A O    1 
ATOM   2776 C CB   . TRP B  1 95  ? 110.066 113.063 106.121 1.00 52.07  ? 95  TRP A CB   1 
ATOM   2777 C CG   . TRP B  1 95  ? 110.634 114.420 106.389 1.00 53.75  ? 95  TRP A CG   1 
ATOM   2778 C CD1  . TRP B  1 95  ? 111.035 115.331 105.460 1.00 60.38  ? 95  TRP A CD1  1 
ATOM   2779 C CD2  . TRP B  1 95  ? 110.845 115.033 107.667 1.00 58.79  ? 95  TRP A CD2  1 
ATOM   2780 N NE1  . TRP B  1 95  ? 111.490 116.470 106.076 1.00 62.89  ? 95  TRP A NE1  1 
ATOM   2781 C CE2  . TRP B  1 95  ? 111.383 116.309 107.432 1.00 56.85  ? 95  TRP A CE2  1 
ATOM   2782 C CE3  . TRP B  1 95  ? 110.635 114.621 108.984 1.00 62.08  ? 95  TRP A CE3  1 
ATOM   2783 C CZ2  . TRP B  1 95  ? 111.713 117.180 108.463 1.00 51.22  ? 95  TRP A CZ2  1 
ATOM   2784 C CZ3  . TRP B  1 95  ? 110.964 115.486 110.006 1.00 60.15  ? 95  TRP A CZ3  1 
ATOM   2785 C CH2  . TRP B  1 95  ? 111.498 116.750 109.741 1.00 58.44  ? 95  TRP A CH2  1 
ATOM   2786 N N    . ASP B  1 96  ? 110.823 109.425 106.347 1.00 65.78  ? 96  ASP A N    1 
ATOM   2787 C CA   . ASP B  1 96  ? 110.091 108.173 106.106 1.00 75.71  ? 96  ASP A CA   1 
ATOM   2788 C C    . ASP B  1 96  ? 109.608 107.568 107.421 1.00 82.83  ? 96  ASP A C    1 
ATOM   2789 O O    . ASP B  1 96  ? 108.411 107.600 107.722 1.00 90.78  ? 96  ASP A O    1 
ATOM   2790 C CB   . ASP B  1 96  ? 110.964 107.187 105.327 1.00 76.41  ? 96  ASP A CB   1 
ATOM   2791 C CG   . ASP B  1 96  ? 112.357 107.068 105.896 1.00 82.58  ? 96  ASP A CG   1 
ATOM   2792 O OD1  . ASP B  1 96  ? 112.698 107.864 106.793 1.00 85.50  ? 96  ASP A OD1  1 
ATOM   2793 O OD2  . ASP B  1 96  ? 113.110 106.175 105.454 1.00 84.63  ? 96  ASP A OD2  1 
ATOM   2794 N N    . PHE B  1 97  ? 110.521 107.004 108.210 1.00 77.29  ? 97  PHE A N    1 
ATOM   2795 C CA   . PHE B  1 97  ? 110.330 106.864 109.649 1.00 68.83  ? 97  PHE A CA   1 
ATOM   2796 C C    . PHE B  1 97  ? 111.636 107.159 110.367 1.00 71.68  ? 97  PHE A C    1 
ATOM   2797 O O    . PHE B  1 97  ? 111.650 107.779 111.435 1.00 78.83  ? 97  PHE A O    1 
ATOM   2798 C CB   . PHE B  1 97  ? 109.828 105.469 110.022 1.00 69.64  ? 97  PHE A CB   1 
ATOM   2799 C CG   . PHE B  1 97  ? 109.536 105.311 111.486 1.00 73.41  ? 97  PHE A CG   1 
ATOM   2800 C CD1  . PHE B  1 97  ? 108.314 105.688 112.008 1.00 73.19  ? 97  PHE A CD1  1 
ATOM   2801 C CD2  . PHE B  1 97  ? 110.495 104.806 112.346 1.00 77.16  ? 97  PHE A CD2  1 
ATOM   2802 C CE1  . PHE B  1 97  ? 108.049 105.551 113.356 1.00 72.69  ? 97  PHE A CE1  1 
ATOM   2803 C CE2  . PHE B  1 97  ? 110.234 104.668 113.695 1.00 68.64  ? 97  PHE A CE2  1 
ATOM   2804 C CZ   . PHE B  1 97  ? 109.012 105.043 114.199 1.00 67.13  ? 97  PHE A CZ   1 
ATOM   2805 N N    . THR B  1 98  ? 112.741 106.706 109.772 1.00 73.34  ? 98  THR A N    1 
ATOM   2806 C CA   . THR B  1 98  ? 114.044 106.785 110.413 1.00 77.38  ? 98  THR A CA   1 
ATOM   2807 C C    . THR B  1 98  ? 114.662 108.169 110.274 1.00 79.59  ? 98  THR A C    1 
ATOM   2808 O O    . THR B  1 98  ? 115.368 108.624 111.181 1.00 80.38  ? 98  THR A O    1 
ATOM   2809 C CB   . THR B  1 98  ? 114.983 105.732 109.828 1.00 71.51  ? 98  THR A CB   1 
ATOM   2810 O OG1  . THR B  1 98  ? 114.269 104.499 109.662 1.00 63.54  ? 98  THR A OG1  1 
ATOM   2811 C CG2  . THR B  1 98  ? 116.162 105.505 110.751 1.00 78.09  ? 98  THR A CG2  1 
ATOM   2812 N N    . GLY B  1 99  ? 114.411 108.847 109.156 1.00 74.60  ? 99  GLY A N    1 
ATOM   2813 C CA   . GLY B  1 99  ? 114.840 110.228 109.043 1.00 75.54  ? 99  GLY A CA   1 
ATOM   2814 C C    . GLY B  1 99  ? 114.208 111.106 110.099 1.00 78.67  ? 99  GLY A C    1 
ATOM   2815 O O    . GLY B  1 99  ? 114.859 111.993 110.652 1.00 86.90  ? 99  GLY A O    1 
ATOM   2816 N N    . ALA B  1 100 ? 112.933 110.864 110.405 1.00 61.26  ? 100 ALA A N    1 
ATOM   2817 C CA   . ALA B  1 100 ? 112.277 111.609 111.476 1.00 63.09  ? 100 ALA A CA   1 
ATOM   2818 C C    . ALA B  1 100 ? 112.906 111.307 112.829 1.00 68.47  ? 100 ALA A C    1 
ATOM   2819 O O    . ALA B  1 100 ? 113.071 112.212 113.660 1.00 75.88  ? 100 ALA A O    1 
ATOM   2820 C CB   . ALA B  1 100 ? 110.783 111.293 111.493 1.00 71.08  ? 100 ALA A CB   1 
ATOM   2821 N N    . PHE B  1 101 ? 113.266 110.047 113.075 1.00 56.61  ? 101 PHE A N    1 
ATOM   2822 C CA   . PHE B  1 101 ? 113.922 109.698 114.330 1.00 59.32  ? 101 PHE A CA   1 
ATOM   2823 C C    . PHE B  1 101 ? 115.264 110.408 114.459 1.00 59.63  ? 101 PHE A C    1 
ATOM   2824 O O    . PHE B  1 101 ? 115.584 110.969 115.512 1.00 63.81  ? 101 PHE A O    1 
ATOM   2825 C CB   . PHE B  1 101 ? 114.100 108.181 114.411 1.00 56.49  ? 101 PHE A CB   1 
ATOM   2826 C CG   . PHE B  1 101 ? 114.522 107.689 115.767 1.00 64.19  ? 101 PHE A CG   1 
ATOM   2827 C CD1  . PHE B  1 101 ? 113.582 107.419 116.741 1.00 64.59  ? 101 PHE A CD1  1 
ATOM   2828 C CD2  . PHE B  1 101 ? 115.857 107.482 116.059 1.00 64.96  ? 101 PHE A CD2  1 
ATOM   2829 C CE1  . PHE B  1 101 ? 113.966 106.963 117.985 1.00 59.28  ? 101 PHE A CE1  1 
ATOM   2830 C CE2  . PHE B  1 101 ? 116.245 107.026 117.299 1.00 58.55  ? 101 PHE A CE2  1 
ATOM   2831 C CZ   . PHE B  1 101 ? 115.298 106.766 118.264 1.00 58.02  ? 101 PHE A CZ   1 
ATOM   2832 N N    . TYR B  1 102 ? 116.020 110.418 113.367 1.00 51.15  ? 102 TYR A N    1 
ATOM   2833 C CA   . TYR B  1 102 ? 117.321 111.124 113.374 1.00 52.02  ? 102 TYR A CA   1 
ATOM   2834 C C    . TYR B  1 102 ? 117.096 112.612 113.637 1.00 56.59  ? 102 TYR A C    1 
ATOM   2835 O O    . TYR B  1 102 ? 117.819 113.194 114.467 1.00 64.47  ? 102 TYR A O    1 
ATOM   2836 C CB   . TYR B  1 102 ? 118.004 110.908 112.022 1.00 55.23  ? 102 TYR A CB   1 
ATOM   2837 C CG   . TYR B  1 102 ? 119.489 111.162 111.981 1.00 62.65  ? 102 TYR A CG   1 
ATOM   2838 C CD1  . TYR B  1 102 ? 120.142 111.814 113.014 1.00 66.41  ? 102 TYR A CD1  1 
ATOM   2839 C CD2  . TYR B  1 102 ? 120.244 110.752 110.895 1.00 58.24  ? 102 TYR A CD2  1 
ATOM   2840 C CE1  . TYR B  1 102 ? 121.505 112.051 112.969 1.00 65.30  ? 102 TYR A CE1  1 
ATOM   2841 C CE2  . TYR B  1 102 ? 121.607 110.979 110.834 1.00 57.57  ? 102 TYR A CE2  1 
ATOM   2842 C CZ   . TYR B  1 102 ? 122.240 111.631 111.875 1.00 64.00  ? 102 TYR A CZ   1 
ATOM   2843 O OH   . TYR B  1 102 ? 123.591 111.856 111.813 1.00 68.90  ? 102 TYR A OH   1 
ATOM   2844 N N    . PHE B  1 103 ? 116.116 113.201 112.953 1.00 52.54  ? 103 PHE A N    1 
ATOM   2845 C CA   . PHE B  1 103 ? 115.851 114.628 113.087 1.00 48.80  ? 103 PHE A CA   1 
ATOM   2846 C C    . PHE B  1 103 ? 115.496 114.989 114.524 1.00 54.39  ? 103 PHE A C    1 
ATOM   2847 O O    . PHE B  1 103 ? 116.029 115.954 115.082 1.00 65.39  ? 103 PHE A O    1 
ATOM   2848 C CB   . PHE B  1 103 ? 114.727 115.033 112.133 1.00 52.42  ? 103 PHE A CB   1 
ATOM   2849 C CG   . PHE B  1 103 ? 114.221 116.426 112.342 1.00 57.49  ? 103 PHE A CG   1 
ATOM   2850 C CD1  . PHE B  1 103 ? 114.979 117.518 111.962 1.00 59.92  ? 103 PHE A CD1  1 
ATOM   2851 C CD2  . PHE B  1 103 ? 112.980 116.644 112.907 1.00 59.07  ? 103 PHE A CD2  1 
ATOM   2852 C CE1  . PHE B  1 103 ? 114.511 118.797 112.154 1.00 55.98  ? 103 PHE A CE1  1 
ATOM   2853 C CE2  . PHE B  1 103 ? 112.508 117.923 113.099 1.00 58.87  ? 103 PHE A CE2  1 
ATOM   2854 C CZ   . PHE B  1 103 ? 113.276 119.001 112.720 1.00 54.86  ? 103 PHE A CZ   1 
ATOM   2855 N N    . VAL B  1 104 ? 114.592 114.227 115.144 1.00 49.52  ? 104 VAL A N    1 
ATOM   2856 C CA   . VAL B  1 104 ? 114.200 114.542 116.515 1.00 44.54  ? 104 VAL A CA   1 
ATOM   2857 C C    . VAL B  1 104 ? 115.356 114.299 117.478 1.00 50.95  ? 104 VAL A C    1 
ATOM   2858 O O    . VAL B  1 104 ? 115.520 115.039 118.459 1.00 50.81  ? 104 VAL A O    1 
ATOM   2859 C CB   . VAL B  1 104 ? 112.953 113.739 116.924 1.00 39.12  ? 104 VAL A CB   1 
ATOM   2860 C CG1  . VAL B  1 104 ? 111.787 114.082 116.020 1.00 43.14  ? 104 VAL A CG1  1 
ATOM   2861 C CG2  . VAL B  1 104 ? 113.239 112.253 116.888 1.00 46.48  ? 104 VAL A CG2  1 
ATOM   2862 N N    . GLY B  1 105 ? 116.182 113.284 117.221 1.00 53.40  ? 105 GLY A N    1 
ATOM   2863 C CA   . GLY B  1 105 ? 117.360 113.094 118.044 1.00 45.48  ? 105 GLY A CA   1 
ATOM   2864 C C    . GLY B  1 105 ? 118.311 114.272 117.979 1.00 45.95  ? 105 GLY A C    1 
ATOM   2865 O O    . GLY B  1 105 ? 118.900 114.663 118.990 1.00 48.29  ? 105 GLY A O    1 
ATOM   2866 N N    . THR B  1 106 ? 118.475 114.852 116.790 1.00 56.48  ? 106 THR A N    1 
ATOM   2867 C CA   . THR B  1 106 ? 119.311 116.047 116.682 1.00 48.42  ? 106 THR A CA   1 
ATOM   2868 C C    . THR B  1 106 ? 118.645 117.260 117.317 1.00 51.78  ? 106 THR A C    1 
ATOM   2869 O O    . THR B  1 106 ? 119.336 118.155 117.816 1.00 55.32  ? 106 THR A O    1 
ATOM   2870 C CB   . THR B  1 106 ? 119.638 116.344 115.217 1.00 48.16  ? 106 THR A CB   1 
ATOM   2871 O OG1  . THR B  1 106 ? 118.425 116.522 114.478 1.00 55.76  ? 106 THR A OG1  1 
ATOM   2872 C CG2  . THR B  1 106 ? 120.437 115.208 114.610 1.00 48.68  ? 106 THR A CG2  1 
ATOM   2873 N N    . VAL B  1 107 ? 117.314 117.322 117.298 1.00 47.14  ? 107 VAL A N    1 
ATOM   2874 C CA   . VAL B  1 107 ? 116.615 118.479 117.849 1.00 39.52  ? 107 VAL A CA   1 
ATOM   2875 C C    . VAL B  1 107 ? 116.714 118.499 119.371 1.00 48.76  ? 107 VAL A C    1 
ATOM   2876 O O    . VAL B  1 107 ? 117.040 119.531 119.968 1.00 55.60  ? 107 VAL A O    1 
ATOM   2877 C CB   . VAL B  1 107 ? 115.149 118.496 117.384 1.00 37.55  ? 107 VAL A CB   1 
ATOM   2878 C CG1  . VAL B  1 107 ? 114.343 119.462 118.226 1.00 43.61  ? 107 VAL A CG1  1 
ATOM   2879 C CG2  . VAL B  1 107 ? 115.069 118.876 115.919 1.00 47.32  ? 107 VAL A CG2  1 
ATOM   2880 N N    . VAL B  1 108 ? 116.428 117.371 120.023 1.00 62.98  ? 108 VAL A N    1 
ATOM   2881 C CA   . VAL B  1 108 ? 116.343 117.387 121.481 1.00 52.07  ? 108 VAL A CA   1 
ATOM   2882 C C    . VAL B  1 108 ? 117.703 117.559 122.143 1.00 49.53  ? 108 VAL A C    1 
ATOM   2883 O O    . VAL B  1 108 ? 117.770 117.963 123.308 1.00 52.97  ? 108 VAL A O    1 
ATOM   2884 C CB   . VAL B  1 108 ? 115.657 116.113 122.008 1.00 44.72  ? 108 VAL A CB   1 
ATOM   2885 C CG1  . VAL B  1 108 ? 114.230 116.038 121.500 1.00 51.37  ? 108 VAL A CG1  1 
ATOM   2886 C CG2  . VAL B  1 108 ? 116.440 114.883 121.601 1.00 50.52  ? 108 VAL A CG2  1 
ATOM   2887 N N    . SER B  1 109 ? 118.792 117.262 121.442 1.00 59.92  ? 109 SER A N    1 
ATOM   2888 C CA   . SER B  1 109 ? 120.133 117.444 121.986 1.00 54.19  ? 109 SER A CA   1 
ATOM   2889 C C    . SER B  1 109 ? 120.748 118.785 121.606 1.00 56.65  ? 109 SER A C    1 
ATOM   2890 O O    . SER B  1 109 ? 121.900 119.042 121.966 1.00 61.55  ? 109 SER A O    1 
ATOM   2891 C CB   . SER B  1 109 ? 121.047 116.306 121.528 1.00 49.66  ? 109 SER A CB   1 
ATOM   2892 O OG   . SER B  1 109 ? 121.057 116.200 120.118 1.00 54.61  ? 109 SER A OG   1 
ATOM   2893 N N    . THR B  1 110 ? 120.005 119.643 120.907 1.00 56.34  ? 110 THR A N    1 
ATOM   2894 C CA   . THR B  1 110 ? 120.492 120.955 120.485 1.00 55.07  ? 110 THR A CA   1 
ATOM   2895 C C    . THR B  1 110 ? 121.764 120.853 119.643 1.00 55.21  ? 110 THR A C    1 
ATOM   2896 O O    . THR B  1 110 ? 122.682 121.664 119.777 1.00 65.76  ? 110 THR A O    1 
ATOM   2897 C CB   . THR B  1 110 ? 120.718 121.876 121.685 1.00 60.98  ? 110 THR A CB   1 
ATOM   2898 O OG1  . THR B  1 110 ? 121.722 121.313 122.539 1.00 65.30  ? 110 THR A OG1  1 
ATOM   2899 C CG2  . THR B  1 110 ? 119.433 122.058 122.467 1.00 61.55  ? 110 THR A CG2  1 
ATOM   2900 N N    . ILE B  1 111 ? 121.821 119.857 118.763 1.00 44.05  ? 111 ILE A N    1 
ATOM   2901 C CA   . ILE B  1 111 ? 122.913 119.755 117.799 1.00 55.71  ? 111 ILE A CA   1 
ATOM   2902 C C    . ILE B  1 111 ? 122.511 120.547 116.563 1.00 62.44  ? 111 ILE A C    1 
ATOM   2903 O O    . ILE B  1 111 ? 123.205 121.484 116.160 1.00 66.59  ? 111 ILE A O    1 
ATOM   2904 C CB   . ILE B  1 111 ? 123.245 118.293 117.456 1.00 56.06  ? 111 ILE A CB   1 
ATOM   2905 C CG1  . ILE B  1 111 ? 123.809 117.578 118.683 1.00 55.01  ? 111 ILE A CG1  1 
ATOM   2906 C CG2  . ILE B  1 111 ? 124.245 118.236 116.316 1.00 48.08  ? 111 ILE A CG2  1 
ATOM   2907 C CD1  . ILE B  1 111 ? 124.227 116.155 118.421 1.00 50.17  ? 111 ILE A CD1  1 
ATOM   2908 N N    . GLY B  1 112 ? 121.387 120.179 115.959 1.00 54.43  ? 112 GLY A N    1 
ATOM   2909 C CA   . GLY B  1 112 ? 120.881 120.917 114.814 1.00 47.25  ? 112 GLY A CA   1 
ATOM   2910 C C    . GLY B  1 112 ? 121.642 120.843 113.509 1.00 50.98  ? 112 GLY A C    1 
ATOM   2911 O O    . GLY B  1 112 ? 121.832 121.880 112.861 1.00 70.18  ? 112 GLY A O    1 
ATOM   2912 N N    . PHE B  1 113 ? 122.112 119.655 113.113 1.00 56.33  ? 113 PHE A N    1 
ATOM   2913 C CA   . PHE B  1 113 ? 123.017 119.561 111.968 1.00 57.28  ? 113 PHE A CA   1 
ATOM   2914 C C    . PHE B  1 113 ? 122.514 120.387 110.788 1.00 65.73  ? 113 PHE A C    1 
ATOM   2915 O O    . PHE B  1 113 ? 123.294 121.080 110.130 1.00 74.55  ? 113 PHE A O    1 
ATOM   2916 C CB   . PHE B  1 113 ? 123.194 118.103 111.545 1.00 56.33  ? 113 PHE A CB   1 
ATOM   2917 C CG   . PHE B  1 113 ? 124.161 117.334 112.390 1.00 61.29  ? 113 PHE A CG   1 
ATOM   2918 C CD1  . PHE B  1 113 ? 125.367 117.891 112.763 1.00 63.55  ? 113 PHE A CD1  1 
ATOM   2919 C CD2  . PHE B  1 113 ? 123.871 116.046 112.795 1.00 65.73  ? 113 PHE A CD2  1 
ATOM   2920 C CE1  . PHE B  1 113 ? 126.260 117.182 113.532 1.00 64.43  ? 113 PHE A CE1  1 
ATOM   2921 C CE2  . PHE B  1 113 ? 124.759 115.331 113.565 1.00 61.40  ? 113 PHE A CE2  1 
ATOM   2922 C CZ   . PHE B  1 113 ? 125.956 115.900 113.933 1.00 62.44  ? 113 PHE A CZ   1 
ATOM   2923 N N    . GLY B  1 114 ? 121.216 120.322 110.508 1.00 62.57  ? 114 GLY A N    1 
ATOM   2924 C CA   . GLY B  1 114 ? 120.617 121.099 109.447 1.00 65.43  ? 114 GLY A CA   1 
ATOM   2925 C C    . GLY B  1 114 ? 120.398 120.367 108.142 1.00 63.87  ? 114 GLY A C    1 
ATOM   2926 O O    . GLY B  1 114 ? 119.941 120.989 107.175 1.00 65.57  ? 114 GLY A O    1 
ATOM   2927 N N    . MET B  1 115 ? 120.707 119.071 108.077 1.00 66.66  ? 115 MET A N    1 
ATOM   2928 C CA   . MET B  1 115 ? 120.453 118.309 106.860 1.00 67.77  ? 115 MET A CA   1 
ATOM   2929 C C    . MET B  1 115 ? 118.970 118.059 106.629 1.00 74.01  ? 115 MET A C    1 
ATOM   2930 O O    . MET B  1 115 ? 118.570 117.795 105.490 1.00 77.94  ? 115 MET A O    1 
ATOM   2931 C CB   . MET B  1 115 ? 121.202 116.980 106.910 1.00 66.96  ? 115 MET A CB   1 
ATOM   2932 C CG   . MET B  1 115 ? 120.487 115.892 107.688 1.00 72.93  ? 115 MET A CG   1 
ATOM   2933 S SD   . MET B  1 115 ? 120.425 116.236 109.457 1.00 88.07  ? 115 MET A SD   1 
ATOM   2934 C CE   . MET B  1 115 ? 119.617 114.763 110.066 1.00 69.81  ? 115 MET A CE   1 
ATOM   2935 N N    . THR B  1 116 ? 118.146 118.143 107.672 1.00 67.57  ? 116 THR A N    1 
ATOM   2936 C CA   . THR B  1 116 ? 116.707 117.941 107.562 1.00 61.26  ? 116 THR A CA   1 
ATOM   2937 C C    . THR B  1 116 ? 116.006 119.035 108.349 1.00 61.49  ? 116 THR A C    1 
ATOM   2938 O O    . THR B  1 116 ? 116.258 119.194 109.546 1.00 65.81  ? 116 THR A O    1 
ATOM   2939 C CB   . THR B  1 116 ? 116.292 116.562 108.081 1.00 60.17  ? 116 THR A CB   1 
ATOM   2940 O OG1  . THR B  1 116 ? 117.102 115.554 107.468 1.00 67.28  ? 116 THR A OG1  1 
ATOM   2941 C CG2  . THR B  1 116 ? 114.838 116.292 107.762 1.00 61.14  ? 116 THR A CG2  1 
ATOM   2942 N N    . THR B  1 117 ? 115.137 119.790 107.686 1.00 61.27  ? 117 THR A N    1 
ATOM   2943 C CA   . THR B  1 117 ? 114.413 120.874 108.322 1.00 54.92  ? 117 THR A CA   1 
ATOM   2944 C C    . THR B  1 117 ? 112.937 120.808 107.948 1.00 59.80  ? 117 THR A C    1 
ATOM   2945 O O    . THR B  1 117 ? 112.584 120.332 106.866 1.00 67.28  ? 117 THR A O    1 
ATOM   2946 C CB   . THR B  1 117 ? 114.977 122.240 107.913 1.00 56.92  ? 117 THR A CB   1 
ATOM   2947 O OG1  . THR B  1 117 ? 114.949 122.362 106.486 1.00 71.72  ? 117 THR A OG1  1 
ATOM   2948 C CG2  . THR B  1 117 ? 116.407 122.387 108.391 1.00 57.78  ? 117 THR A CG2  1 
ATOM   2949 N N    . PRO B  1 118 ? 112.056 121.280 108.826 1.00 60.24  ? 118 PRO A N    1 
ATOM   2950 C CA   . PRO B  1 118 ? 110.632 121.342 108.480 1.00 64.68  ? 118 PRO A CA   1 
ATOM   2951 C C    . PRO B  1 118 ? 110.387 122.326 107.350 1.00 63.21  ? 118 PRO A C    1 
ATOM   2952 O O    . PRO B  1 118 ? 111.096 123.322 107.193 1.00 64.99  ? 118 PRO A O    1 
ATOM   2953 C CB   . PRO B  1 118 ? 109.970 121.815 109.779 1.00 62.82  ? 118 PRO A CB   1 
ATOM   2954 C CG   . PRO B  1 118 ? 110.954 121.498 110.851 1.00 63.07  ? 118 PRO A CG   1 
ATOM   2955 C CD   . PRO B  1 118 ? 112.300 121.676 110.221 1.00 62.31  ? 118 PRO A CD   1 
ATOM   2956 N N    . ALA B  1 119 ? 109.358 122.036 106.551 1.00 68.59  ? 119 ALA A N    1 
ATOM   2957 C CA   . ALA B  1 119 ? 109.070 122.830 105.365 1.00 72.59  ? 119 ALA A CA   1 
ATOM   2958 C C    . ALA B  1 119 ? 107.628 123.302 105.247 1.00 75.30  ? 119 ALA A C    1 
ATOM   2959 O O    . ALA B  1 119 ? 107.359 124.171 104.410 1.00 76.47  ? 119 ALA A O    1 
ATOM   2960 C CB   . ALA B  1 119 ? 109.431 122.046 104.096 1.00 72.07  ? 119 ALA A CB   1 
ATOM   2961 N N    . THR B  1 120 ? 106.701 122.775 106.040 1.00 72.21  ? 120 THR A N    1 
ATOM   2962 C CA   . THR B  1 120 ? 105.299 123.148 105.955 1.00 71.15  ? 120 THR A CA   1 
ATOM   2963 C C    . THR B  1 120 ? 104.846 123.810 107.245 1.00 74.28  ? 120 THR A C    1 
ATOM   2964 O O    . THR B  1 120 ? 105.310 123.463 108.337 1.00 81.99  ? 120 THR A O    1 
ATOM   2965 C CB   . THR B  1 120 ? 104.408 121.932 105.672 1.00 70.13  ? 120 THR A CB   1 
ATOM   2966 O OG1  . THR B  1 120 ? 104.467 121.034 106.784 1.00 70.80  ? 120 THR A OG1  1 
ATOM   2967 C CG2  . THR B  1 120 ? 104.872 121.212 104.421 1.00 74.68  ? 120 THR A CG2  1 
ATOM   2968 N N    . VAL B  1 121 ? 103.927 124.765 107.116 1.00 82.36  ? 121 VAL A N    1 
ATOM   2969 C CA   . VAL B  1 121 ? 103.329 125.387 108.291 1.00 82.00  ? 121 VAL A CA   1 
ATOM   2970 C C    . VAL B  1 121 ? 102.498 124.347 109.027 1.00 84.83  ? 121 VAL A C    1 
ATOM   2971 O O    . VAL B  1 121 ? 101.683 123.639 108.425 1.00 88.25  ? 121 VAL A O    1 
ATOM   2972 C CB   . VAL B  1 121 ? 102.477 126.598 107.891 1.00 79.02  ? 121 VAL A CB   1 
ATOM   2973 C CG1  . VAL B  1 121 ? 101.524 126.226 106.771 1.00 82.36  ? 121 VAL A CG1  1 
ATOM   2974 C CG2  . VAL B  1 121 ? 101.711 127.123 109.092 1.00 77.03  ? 121 VAL A CG2  1 
ATOM   2975 N N    . GLY B  1 122 ? 102.702 124.250 110.335 1.00 80.67  ? 122 GLY A N    1 
ATOM   2976 C CA   . GLY B  1 122 ? 102.119 123.167 111.099 1.00 82.20  ? 122 GLY A CA   1 
ATOM   2977 C C    . GLY B  1 122 ? 103.198 122.196 111.520 1.00 81.59  ? 122 GLY A C    1 
ATOM   2978 O O    . GLY B  1 122 ? 103.150 121.631 112.616 1.00 92.07  ? 122 GLY A O    1 
ATOM   2979 N N    . GLY B  1 123 ? 104.178 121.993 110.644 1.00 65.69  ? 123 GLY A N    1 
ATOM   2980 C CA   . GLY B  1 123 ? 105.375 121.270 111.015 1.00 67.11  ? 123 GLY A CA   1 
ATOM   2981 C C    . GLY B  1 123 ? 106.399 122.097 111.751 1.00 75.76  ? 123 GLY A C    1 
ATOM   2982 O O    . GLY B  1 123 ? 107.400 121.547 112.221 1.00 77.02  ? 123 GLY A O    1 
ATOM   2983 N N    . LYS B  1 124 ? 106.175 123.403 111.861 1.00 68.35  ? 124 LYS A N    1 
ATOM   2984 C CA   . LYS B  1 124 ? 107.050 124.303 112.598 1.00 64.65  ? 124 LYS A CA   1 
ATOM   2985 C C    . LYS B  1 124 ? 106.548 124.607 114.003 1.00 70.85  ? 124 LYS A C    1 
ATOM   2986 O O    . LYS B  1 124 ? 107.353 124.722 114.929 1.00 76.13  ? 124 LYS A O    1 
ATOM   2987 C CB   . LYS B  1 124 ? 107.228 125.615 111.830 1.00 62.81  ? 124 LYS A CB   1 
ATOM   2988 C CG   . LYS B  1 124 ? 107.857 125.454 110.457 1.00 64.98  ? 124 LYS A CG   1 
ATOM   2989 C CD   . LYS B  1 124 ? 108.072 126.802 109.792 1.00 67.32  ? 124 LYS A CD   1 
ATOM   2990 C CE   . LYS B  1 124 ? 108.726 126.647 108.430 1.00 64.88  ? 124 LYS A CE   1 
ATOM   2991 N NZ   . LYS B  1 124 ? 108.907 127.956 107.750 1.00 65.58  ? 124 LYS A NZ   1 
ATOM   2992 N N    . ILE B  1 125 ? 105.233 124.740 114.183 1.00 64.55  ? 125 ILE A N    1 
ATOM   2993 C CA   . ILE B  1 125 ? 104.681 124.967 115.515 1.00 67.04  ? 125 ILE A CA   1 
ATOM   2994 C C    . ILE B  1 125 ? 104.924 123.748 116.399 1.00 70.00  ? 125 ILE A C    1 
ATOM   2995 O O    . ILE B  1 125 ? 105.371 123.862 117.556 1.00 77.19  ? 125 ILE A O    1 
ATOM   2996 C CB   . ILE B  1 125 ? 103.183 125.300 115.416 1.00 63.13  ? 125 ILE A CB   1 
ATOM   2997 C CG1  . ILE B  1 125 ? 102.923 126.188 114.201 1.00 62.13  ? 125 ILE A CG1  1 
ATOM   2998 C CG2  . ILE B  1 125 ? 102.702 125.976 116.682 1.00 72.64  ? 125 ILE A CG2  1 
ATOM   2999 C CD1  . ILE B  1 125 ? 101.465 126.500 113.981 1.00 60.05  ? 125 ILE A CD1  1 
ATOM   3000 N N    . PHE B  1 126 ? 104.639 122.564 115.865 1.00 55.70  ? 126 PHE A N    1 
ATOM   3001 C CA   . PHE B  1 126 ? 104.923 121.339 116.596 1.00 59.63  ? 126 PHE A CA   1 
ATOM   3002 C C    . PHE B  1 126 ? 106.398 121.244 116.939 1.00 64.53  ? 126 PHE A C    1 
ATOM   3003 O O    . PHE B  1 126 ? 106.752 120.751 118.012 1.00 71.19  ? 126 PHE A O    1 
ATOM   3004 C CB   . PHE B  1 126 ? 104.476 120.128 115.784 1.00 59.28  ? 126 PHE A CB   1 
ATOM   3005 C CG   . PHE B  1 126 ? 104.616 118.825 116.513 1.00 64.92  ? 126 PHE A CG   1 
ATOM   3006 C CD1  . PHE B  1 126 ? 103.795 118.525 117.586 1.00 61.66  ? 126 PHE A CD1  1 
ATOM   3007 C CD2  . PHE B  1 126 ? 105.559 117.894 116.122 1.00 63.48  ? 126 PHE A CD2  1 
ATOM   3008 C CE1  . PHE B  1 126 ? 103.919 117.330 118.255 1.00 60.56  ? 126 PHE A CE1  1 
ATOM   3009 C CE2  . PHE B  1 126 ? 105.684 116.696 116.788 1.00 61.55  ? 126 PHE A CE2  1 
ATOM   3010 C CZ   . PHE B  1 126 ? 104.865 116.414 117.855 1.00 60.64  ? 126 PHE A CZ   1 
ATOM   3011 N N    . LEU B  1 127 ? 107.273 121.735 116.058 1.00 55.77  ? 127 LEU A N    1 
ATOM   3012 C CA   . LEU B  1 127 ? 108.693 121.777 116.380 1.00 58.93  ? 127 LEU A CA   1 
ATOM   3013 C C    . LEU B  1 127 ? 108.949 122.649 117.598 1.00 60.92  ? 127 LEU A C    1 
ATOM   3014 O O    . LEU B  1 127 ? 109.720 122.274 118.492 1.00 68.69  ? 127 LEU A O    1 
ATOM   3015 C CB   . LEU B  1 127 ? 109.489 122.285 115.181 1.00 61.69  ? 127 LEU A CB   1 
ATOM   3016 C CG   . LEU B  1 127 ? 111.015 122.272 115.300 1.00 64.21  ? 127 LEU A CG   1 
ATOM   3017 C CD1  . LEU B  1 127 ? 111.516 123.579 115.885 1.00 61.05  ? 127 LEU A CD1  1 
ATOM   3018 C CD2  . LEU B  1 127 ? 111.480 121.102 116.138 1.00 65.07  ? 127 LEU A CD2  1 
ATOM   3019 N N    . ILE B  1 128 ? 108.294 123.809 117.670 1.00 59.91  ? 128 ILE A N    1 
ATOM   3020 C CA   . ILE B  1 128 ? 108.502 124.708 118.800 1.00 66.55  ? 128 ILE A CA   1 
ATOM   3021 C C    . ILE B  1 128 ? 108.109 124.025 120.101 1.00 68.05  ? 128 ILE A C    1 
ATOM   3022 O O    . ILE B  1 128 ? 108.891 123.974 121.060 1.00 74.14  ? 128 ILE A O    1 
ATOM   3023 C CB   . ILE B  1 128 ? 107.719 126.013 118.595 1.00 64.22  ? 128 ILE A CB   1 
ATOM   3024 C CG1  . ILE B  1 128 ? 108.268 126.791 117.397 1.00 60.14  ? 128 ILE A CG1  1 
ATOM   3025 C CG2  . ILE B  1 128 ? 107.764 126.865 119.850 1.00 63.73  ? 128 ILE A CG2  1 
ATOM   3026 C CD1  . ILE B  1 128 ? 107.530 128.074 117.115 1.00 56.08  ? 128 ILE A CD1  1 
ATOM   3027 N N    . PHE B  1 129 ? 106.901 123.456 120.146 1.00 63.83  ? 129 PHE A N    1 
ATOM   3028 C CA   . PHE B  1 129 ? 106.449 122.839 121.392 1.00 61.55  ? 129 PHE A CA   1 
ATOM   3029 C C    . PHE B  1 129 ? 107.290 121.613 121.751 1.00 64.24  ? 129 PHE A C    1 
ATOM   3030 O O    . PHE B  1 129 ? 107.667 121.429 122.917 1.00 65.50  ? 129 PHE A O    1 
ATOM   3031 C CB   . PHE B  1 129 ? 104.971 122.470 121.287 1.00 65.28  ? 129 PHE A CB   1 
ATOM   3032 C CG   . PHE B  1 129 ? 104.058 123.659 121.206 1.00 67.82  ? 129 PHE A CG   1 
ATOM   3033 C CD1  . PHE B  1 129 ? 103.885 124.487 122.298 1.00 69.71  ? 129 PHE A CD1  1 
ATOM   3034 C CD2  . PHE B  1 129 ? 103.381 123.952 120.038 1.00 64.80  ? 129 PHE A CD2  1 
ATOM   3035 C CE1  . PHE B  1 129 ? 103.047 125.585 122.230 1.00 67.76  ? 129 PHE A CE1  1 
ATOM   3036 C CE2  . PHE B  1 129 ? 102.545 125.047 119.963 1.00 66.13  ? 129 PHE A CE2  1 
ATOM   3037 C CZ   . PHE B  1 129 ? 102.376 125.861 121.061 1.00 67.51  ? 129 PHE A CZ   1 
ATOM   3038 N N    . TYR B  1 130 ? 107.603 120.781 120.758 1.00 58.90  ? 130 TYR A N    1 
ATOM   3039 C CA   . TYR B  1 130 ? 108.388 119.579 121.003 1.00 56.08  ? 130 TYR A CA   1 
ATOM   3040 C C    . TYR B  1 130 ? 109.760 119.925 121.570 1.00 62.67  ? 130 TYR A C    1 
ATOM   3041 O O    . TYR B  1 130 ? 110.196 119.341 122.569 1.00 71.96  ? 130 TYR A O    1 
ATOM   3042 C CB   . TYR B  1 130 ? 108.515 118.793 119.696 1.00 51.37  ? 130 TYR A CB   1 
ATOM   3043 C CG   . TYR B  1 130 ? 109.006 117.374 119.840 1.00 57.72  ? 130 TYR A CG   1 
ATOM   3044 C CD1  . TYR B  1 130 ? 108.142 116.356 120.205 1.00 59.96  ? 130 TYR A CD1  1 
ATOM   3045 C CD2  . TYR B  1 130 ? 110.330 117.049 119.584 1.00 57.15  ? 130 TYR A CD2  1 
ATOM   3046 C CE1  . TYR B  1 130 ? 108.584 115.059 120.330 1.00 62.84  ? 130 TYR A CE1  1 
ATOM   3047 C CE2  . TYR B  1 130 ? 110.779 115.754 119.703 1.00 56.68  ? 130 TYR A CE2  1 
ATOM   3048 C CZ   . TYR B  1 130 ? 109.904 114.764 120.078 1.00 61.93  ? 130 TYR A CZ   1 
ATOM   3049 O OH   . TYR B  1 130 ? 110.346 113.470 120.200 1.00 73.06  ? 130 TYR A OH   1 
ATOM   3050 N N    . GLY B  1 131 ? 110.448 120.888 120.953 1.00 57.81  ? 131 GLY A N    1 
ATOM   3051 C CA   . GLY B  1 131 ? 111.749 121.281 121.459 1.00 57.39  ? 131 GLY A CA   1 
ATOM   3052 C C    . GLY B  1 131 ? 111.674 121.897 122.840 1.00 60.48  ? 131 GLY A C    1 
ATOM   3053 O O    . GLY B  1 131 ? 112.503 121.605 123.710 1.00 70.83  ? 131 GLY A O    1 
ATOM   3054 N N    . LEU B  1 132 ? 110.662 122.740 123.073 1.00 55.12  ? 132 LEU A N    1 
ATOM   3055 C CA   . LEU B  1 132 ? 110.524 123.378 124.377 1.00 58.44  ? 132 LEU A CA   1 
ATOM   3056 C C    . LEU B  1 132 ? 110.357 122.345 125.481 1.00 61.30  ? 132 LEU A C    1 
ATOM   3057 O O    . LEU B  1 132 ? 110.902 122.506 126.577 1.00 62.47  ? 132 LEU A O    1 
ATOM   3058 C CB   . LEU B  1 132 ? 109.341 124.343 124.360 1.00 56.36  ? 132 LEU A CB   1 
ATOM   3059 C CG   . LEU B  1 132 ? 108.994 125.024 125.683 1.00 56.02  ? 132 LEU A CG   1 
ATOM   3060 C CD1  . LEU B  1 132 ? 110.152 125.872 126.171 1.00 59.40  ? 132 LEU A CD1  1 
ATOM   3061 C CD2  . LEU B  1 132 ? 107.739 125.864 125.533 1.00 60.11  ? 132 LEU A CD2  1 
ATOM   3062 N N    . VAL B  1 133 ? 109.610 121.276 125.214 1.00 70.17  ? 133 VAL A N    1 
ATOM   3063 C CA   . VAL B  1 133 ? 109.431 120.273 126.261 1.00 63.08  ? 133 VAL A CA   1 
ATOM   3064 C C    . VAL B  1 133 ? 110.616 119.307 126.342 1.00 63.40  ? 133 VAL A C    1 
ATOM   3065 O O    . VAL B  1 133 ? 110.879 118.745 127.410 1.00 68.50  ? 133 VAL A O    1 
ATOM   3066 C CB   . VAL B  1 133 ? 108.109 119.512 126.069 1.00 65.46  ? 133 VAL A CB   1 
ATOM   3067 C CG1  . VAL B  1 133 ? 107.895 118.551 127.222 1.00 61.41  ? 133 VAL A CG1  1 
ATOM   3068 C CG2  . VAL B  1 133 ? 106.952 120.488 125.981 1.00 66.05  ? 133 VAL A CG2  1 
ATOM   3069 N N    . GLY B  1 134 ? 111.339 119.084 125.245 1.00 60.66  ? 134 GLY A N    1 
ATOM   3070 C CA   . GLY B  1 134 ? 112.389 118.080 125.245 1.00 53.37  ? 134 GLY A CA   1 
ATOM   3071 C C    . GLY B  1 134 ? 113.771 118.526 125.684 1.00 62.69  ? 134 GLY A C    1 
ATOM   3072 O O    . GLY B  1 134 ? 114.523 117.743 126.286 1.00 72.86  ? 134 GLY A O    1 
ATOM   3073 N N    . CYS B  1 135 ? 114.132 119.778 125.384 1.00 52.27  ? 135 CYS A N    1 
ATOM   3074 C CA   . CYS B  1 135 ? 115.473 120.245 125.719 1.00 53.12  ? 135 CYS A CA   1 
ATOM   3075 C C    . CYS B  1 135 ? 115.692 120.268 127.229 1.00 64.97  ? 135 CYS A C    1 
ATOM   3076 O O    . CYS B  1 135 ? 116.780 119.925 127.714 1.00 71.34  ? 135 CYS A O    1 
ATOM   3077 C CB   . CYS B  1 135 ? 115.707 121.627 125.116 1.00 62.32  ? 135 CYS A CB   1 
ATOM   3078 S SG   . CYS B  1 135 ? 115.618 121.675 123.312 1.00 70.65  ? 135 CYS A SG   1 
ATOM   3079 N N    . SER B  1 136 ? 114.668 120.666 127.987 1.00 52.97  ? 136 SER A N    1 
ATOM   3080 C CA   . SER B  1 136 ? 114.784 120.676 129.440 1.00 52.03  ? 136 SER A CA   1 
ATOM   3081 C C    . SER B  1 136 ? 115.010 119.274 129.987 1.00 59.56  ? 136 SER A C    1 
ATOM   3082 O O    . SER B  1 136 ? 115.840 119.069 130.883 1.00 70.08  ? 136 SER A O    1 
ATOM   3083 C CB   . SER B  1 136 ? 113.529 121.292 130.051 1.00 59.97  ? 136 SER A CB   1 
ATOM   3084 O OG   . SER B  1 136 ? 113.125 122.438 129.325 1.00 65.45  ? 136 SER A OG   1 
ATOM   3085 N N    . SER B  1 137 ? 114.276 118.289 129.461 1.00 49.84  ? 137 SER A N    1 
ATOM   3086 C CA   . SER B  1 137 ? 114.457 116.914 129.904 1.00 47.16  ? 137 SER A CA   1 
ATOM   3087 C C    . SER B  1 137 ? 115.865 116.420 129.597 1.00 58.10  ? 137 SER A C    1 
ATOM   3088 O O    . SER B  1 137 ? 116.484 115.736 130.420 1.00 69.78  ? 137 SER A O    1 
ATOM   3089 C CB   . SER B  1 137 ? 113.417 116.014 129.244 1.00 54.11  ? 137 SER A CB   1 
ATOM   3090 O OG   . SER B  1 137 ? 112.109 116.517 129.443 1.00 62.80  ? 137 SER A OG   1 
ATOM   3091 N N    . THR B  1 138 ? 116.387 116.757 128.419 1.00 57.01  ? 138 THR A N    1 
ATOM   3092 C CA   . THR B  1 138 ? 117.747 116.342 128.087 1.00 53.54  ? 138 THR A CA   1 
ATOM   3093 C C    . THR B  1 138 ? 118.773 116.970 129.028 1.00 53.58  ? 138 THR A C    1 
ATOM   3094 O O    . THR B  1 138 ? 119.726 116.308 129.461 1.00 60.57  ? 138 THR A O    1 
ATOM   3095 C CB   . THR B  1 138 ? 118.062 116.682 126.633 1.00 53.65  ? 138 THR A CB   1 
ATOM   3096 O OG1  . THR B  1 138 ? 117.061 116.111 125.785 1.00 56.65  ? 138 THR A OG1  1 
ATOM   3097 C CG2  . THR B  1 138 ? 119.417 116.121 126.244 1.00 56.05  ? 138 THR A CG2  1 
ATOM   3098 N N    . ILE B  1 139 ? 118.594 118.250 129.359 1.00 50.34  ? 139 ILE A N    1 
ATOM   3099 C CA   . ILE B  1 139 ? 119.511 118.905 130.291 1.00 54.20  ? 139 ILE A CA   1 
ATOM   3100 C C    . ILE B  1 139 ? 119.462 118.232 131.659 1.00 59.87  ? 139 ILE A C    1 
ATOM   3101 O O    . ILE B  1 139 ? 120.499 117.996 132.298 1.00 68.96  ? 139 ILE A O    1 
ATOM   3102 C CB   . ILE B  1 139 ? 119.193 120.407 130.388 1.00 52.90  ? 139 ILE A CB   1 
ATOM   3103 C CG1  . ILE B  1 139 ? 119.511 121.104 129.065 1.00 51.22  ? 139 ILE A CG1  1 
ATOM   3104 C CG2  . ILE B  1 139 ? 119.968 121.039 131.526 1.00 56.13  ? 139 ILE A CG2  1 
ATOM   3105 C CD1  . ILE B  1 139 ? 119.249 122.591 129.080 1.00 54.39  ? 139 ILE A CD1  1 
ATOM   3106 N N    . LEU B  1 140 ? 118.253 117.915 132.131 1.00 56.78  ? 140 LEU A N    1 
ATOM   3107 C CA   . LEU B  1 140 ? 118.123 117.217 133.405 1.00 52.80  ? 140 LEU A CA   1 
ATOM   3108 C C    . LEU B  1 140 ? 118.825 115.867 133.364 1.00 57.54  ? 140 LEU A C    1 
ATOM   3109 O O    . LEU B  1 140 ? 119.490 115.469 134.332 1.00 63.81  ? 140 LEU A O    1 
ATOM   3110 C CB   . LEU B  1 140 ? 116.644 117.044 133.754 1.00 44.43  ? 140 LEU A CB   1 
ATOM   3111 C CG   . LEU B  1 140 ? 116.319 116.273 135.029 1.00 45.29  ? 140 LEU A CG   1 
ATOM   3112 C CD1  . LEU B  1 140 ? 116.913 116.968 136.237 1.00 50.89  ? 140 LEU A CD1  1 
ATOM   3113 C CD2  . LEU B  1 140 ? 114.818 116.118 135.181 1.00 48.99  ? 140 LEU A CD2  1 
ATOM   3114 N N    . PHE B  1 141 ? 118.690 115.148 132.249 1.00 55.13  ? 141 PHE A N    1 
ATOM   3115 C CA   . PHE B  1 141 ? 119.364 113.862 132.109 1.00 50.47  ? 141 PHE A CA   1 
ATOM   3116 C C    . PHE B  1 141 ? 120.875 114.016 132.203 1.00 55.40  ? 141 PHE A C    1 
ATOM   3117 O O    . PHE B  1 141 ? 121.546 113.220 132.873 1.00 69.39  ? 141 PHE A O    1 
ATOM   3118 C CB   . PHE B  1 141 ? 118.967 113.216 130.782 1.00 50.14  ? 141 PHE A CB   1 
ATOM   3119 C CG   . PHE B  1 141 ? 119.538 111.847 130.575 1.00 58.62  ? 141 PHE A CG   1 
ATOM   3120 C CD1  . PHE B  1 141 ? 118.912 110.733 131.099 1.00 57.57  ? 141 PHE A CD1  1 
ATOM   3121 C CD2  . PHE B  1 141 ? 120.698 111.672 129.844 1.00 60.38  ? 141 PHE A CD2  1 
ATOM   3122 C CE1  . PHE B  1 141 ? 119.432 109.472 130.907 1.00 57.35  ? 141 PHE A CE1  1 
ATOM   3123 C CE2  . PHE B  1 141 ? 121.224 110.409 129.649 1.00 59.57  ? 141 PHE A CE2  1 
ATOM   3124 C CZ   . PHE B  1 141 ? 120.591 109.313 130.182 1.00 59.49  ? 141 PHE A CZ   1 
ATOM   3125 N N    . PHE B  1 142 ? 121.427 115.032 131.546 1.00 57.94  ? 142 PHE A N    1 
ATOM   3126 C CA   . PHE B  1 142 ? 122.871 115.245 131.612 1.00 57.73  ? 142 PHE A CA   1 
ATOM   3127 C C    . PHE B  1 142 ? 123.325 115.540 133.039 1.00 60.64  ? 142 PHE A C    1 
ATOM   3128 O O    . PHE B  1 142 ? 124.351 115.009 133.502 1.00 68.62  ? 142 PHE A O    1 
ATOM   3129 C CB   . PHE B  1 142 ? 123.286 116.378 130.674 1.00 56.71  ? 142 PHE A CB   1 
ATOM   3130 C CG   . PHE B  1 142 ? 123.136 116.048 129.216 1.00 61.85  ? 142 PHE A CG   1 
ATOM   3131 C CD1  . PHE B  1 142 ? 123.083 114.734 128.792 1.00 62.00  ? 142 PHE A CD1  1 
ATOM   3132 C CD2  . PHE B  1 142 ? 123.053 117.054 128.270 1.00 62.36  ? 142 PHE A CD2  1 
ATOM   3133 C CE1  . PHE B  1 142 ? 122.944 114.429 127.453 1.00 61.95  ? 142 PHE A CE1  1 
ATOM   3134 C CE2  . PHE B  1 142 ? 122.917 116.754 126.931 1.00 60.76  ? 142 PHE A CE2  1 
ATOM   3135 C CZ   . PHE B  1 142 ? 122.861 115.439 126.522 1.00 58.58  ? 142 PHE A CZ   1 
ATOM   3136 N N    . ASN B  1 143 ? 122.572 116.374 133.758 1.00 59.67  ? 143 ASN A N    1 
ATOM   3137 C CA   . ASN B  1 143 ? 122.950 116.683 135.138 1.00 59.97  ? 143 ASN A CA   1 
ATOM   3138 C C    . ASN B  1 143 ? 122.914 115.437 136.018 1.00 63.58  ? 143 ASN A C    1 
ATOM   3139 O O    . ASN B  1 143 ? 123.824 115.206 136.833 1.00 70.84  ? 143 ASN A O    1 
ATOM   3140 C CB   . ASN B  1 143 ? 122.035 117.768 135.706 1.00 62.24  ? 143 ASN A CB   1 
ATOM   3141 C CG   . ASN B  1 143 ? 122.214 119.102 135.007 1.00 72.03  ? 143 ASN A CG   1 
ATOM   3142 O OD1  . ASN B  1 143 ? 123.257 119.369 134.413 1.00 74.33  ? 143 ASN A OD1  1 
ATOM   3143 N ND2  . ASN B  1 143 ? 121.194 119.946 135.080 1.00 72.15  ? 143 ASN A ND2  1 
ATOM   3144 N N    . LEU B  1 144 ? 121.873 114.615 135.869 1.00 60.90  ? 144 LEU A N    1 
ATOM   3145 C CA   . LEU B  1 144 ? 121.792 113.388 136.657 1.00 60.97  ? 144 LEU A CA   1 
ATOM   3146 C C    . LEU B  1 144 ? 122.944 112.447 136.329 1.00 63.17  ? 144 LEU A C    1 
ATOM   3147 O O    . LEU B  1 144 ? 123.499 111.794 137.225 1.00 66.29  ? 144 LEU A O    1 
ATOM   3148 C CB   . LEU B  1 144 ? 120.450 112.700 136.419 1.00 56.22  ? 144 LEU A CB   1 
ATOM   3149 C CG   . LEU B  1 144 ? 119.207 113.479 136.856 1.00 56.84  ? 144 LEU A CG   1 
ATOM   3150 C CD1  . LEU B  1 144 ? 117.961 112.637 136.688 1.00 59.70  ? 144 LEU A CD1  1 
ATOM   3151 C CD2  . LEU B  1 144 ? 119.348 113.945 138.292 1.00 60.12  ? 144 LEU A CD2  1 
ATOM   3152 N N    . PHE B  1 145 ? 123.321 112.363 135.051 1.00 61.51  ? 145 PHE A N    1 
ATOM   3153 C CA   . PHE B  1 145 ? 124.466 111.536 134.685 1.00 60.06  ? 145 PHE A CA   1 
ATOM   3154 C C    . PHE B  1 145 ? 125.738 112.017 135.367 1.00 63.05  ? 145 PHE A C    1 
ATOM   3155 O O    . PHE B  1 145 ? 126.529 111.211 135.868 1.00 65.01  ? 145 PHE A O    1 
ATOM   3156 C CB   . PHE B  1 145 ? 124.657 111.529 133.170 1.00 56.95  ? 145 PHE A CB   1 
ATOM   3157 C CG   . PHE B  1 145 ? 125.984 110.977 132.737 1.00 61.56  ? 145 PHE A CG   1 
ATOM   3158 C CD1  . PHE B  1 145 ? 126.180 109.614 132.639 1.00 62.11  ? 145 PHE A CD1  1 
ATOM   3159 C CD2  . PHE B  1 145 ? 127.039 111.822 132.449 1.00 64.36  ? 145 PHE A CD2  1 
ATOM   3160 C CE1  . PHE B  1 145 ? 127.403 109.105 132.250 1.00 61.76  ? 145 PHE A CE1  1 
ATOM   3161 C CE2  . PHE B  1 145 ? 128.263 111.319 132.061 1.00 62.69  ? 145 PHE A CE2  1 
ATOM   3162 C CZ   . PHE B  1 145 ? 128.443 109.960 131.959 1.00 61.34  ? 145 PHE A CZ   1 
ATOM   3163 N N    . LEU B  1 146 ? 125.960 113.333 135.387 1.00 64.67  ? 146 LEU A N    1 
ATOM   3164 C CA   . LEU B  1 146 ? 127.163 113.846 136.041 1.00 61.96  ? 146 LEU A CA   1 
ATOM   3165 C C    . LEU B  1 146 ? 127.172 113.504 137.525 1.00 63.99  ? 146 LEU A C    1 
ATOM   3166 O O    . LEU B  1 146 ? 128.208 113.100 138.076 1.00 69.07  ? 146 LEU A O    1 
ATOM   3167 C CB   . LEU B  1 146 ? 127.270 115.356 135.840 1.00 65.01  ? 146 LEU A CB   1 
ATOM   3168 C CG   . LEU B  1 146 ? 128.437 116.037 136.554 1.00 63.61  ? 146 LEU A CG   1 
ATOM   3169 C CD1  . LEU B  1 146 ? 129.750 115.386 136.169 1.00 61.29  ? 146 LEU A CD1  1 
ATOM   3170 C CD2  . LEU B  1 146 ? 128.465 117.519 136.236 1.00 62.70  ? 146 LEU A CD2  1 
ATOM   3171 N N    . GLU B  1 147 ? 126.025 113.653 138.192 1.00 76.68  ? 147 GLU A N    1 
ATOM   3172 C CA   . GLU B  1 147 ? 125.962 113.310 139.611 1.00 72.10  ? 147 GLU A CA   1 
ATOM   3173 C C    . GLU B  1 147 ? 126.278 111.836 139.841 1.00 76.72  ? 147 GLU A C    1 
ATOM   3174 O O    . GLU B  1 147 ? 127.048 111.486 140.751 1.00 81.52  ? 147 GLU A O    1 
ATOM   3175 C CB   . GLU B  1 147 ? 124.586 113.649 140.177 1.00 76.52  ? 147 GLU A CB   1 
ATOM   3176 C CG   . GLU B  1 147 ? 124.366 113.133 141.587 1.00 83.99  ? 147 GLU A CG   1 
ATOM   3177 C CD   . GLU B  1 147 ? 122.955 113.370 142.082 1.00 93.22  ? 147 GLU A CD   1 
ATOM   3178 O OE1  . GLU B  1 147 ? 122.149 113.954 141.329 1.00 92.84  ? 147 GLU A OE1  1 
ATOM   3179 O OE2  . GLU B  1 147 ? 122.651 112.967 143.226 1.00 91.28  ? 147 GLU A OE2  1 
ATOM   3180 N N    . ARG B  1 148 ? 125.701 110.951 139.023 1.00 71.75  ? 148 ARG A N    1 
ATOM   3181 C CA   . ARG B  1 148 ? 125.971 109.526 139.180 1.00 70.19  ? 148 ARG A CA   1 
ATOM   3182 C C    . ARG B  1 148 ? 127.445 109.212 138.955 1.00 72.08  ? 148 ARG A C    1 
ATOM   3183 O O    . ARG B  1 148 ? 128.033 108.393 139.673 1.00 74.54  ? 148 ARG A O    1 
ATOM   3184 C CB   . ARG B  1 148 ? 125.104 108.715 138.218 1.00 68.75  ? 148 ARG A CB   1 
ATOM   3185 C CG   . ARG B  1 148 ? 123.624 108.723 138.545 1.00 68.10  ? 148 ARG A CG   1 
ATOM   3186 C CD   . ARG B  1 148 ? 123.314 107.798 139.703 1.00 69.97  ? 148 ARG A CD   1 
ATOM   3187 N NE   . ARG B  1 148 ? 123.639 108.406 140.986 1.00 72.39  ? 148 ARG A NE   1 
ATOM   3188 C CZ   . ARG B  1 148 ? 123.573 107.776 142.149 1.00 73.05  ? 148 ARG A CZ   1 
ATOM   3189 N NH1  . ARG B  1 148 ? 123.202 106.509 142.231 1.00 76.51  ? 148 ARG A NH1  1 
ATOM   3190 N NH2  . ARG B  1 148 ? 123.889 108.434 143.262 1.00 71.26  ? 148 ARG A NH2  1 
ATOM   3191 N N    . LEU B  1 149 ? 128.060 109.853 137.960 1.00 72.48  ? 149 LEU A N    1 
ATOM   3192 C CA   . LEU B  1 149 ? 129.472 109.614 137.698 1.00 70.75  ? 149 LEU A CA   1 
ATOM   3193 C C    . LEU B  1 149 ? 130.332 110.025 138.885 1.00 70.66  ? 149 LEU A C    1 
ATOM   3194 O O    . LEU B  1 149 ? 131.243 109.294 139.288 1.00 71.10  ? 149 LEU A O    1 
ATOM   3195 C CB   . LEU B  1 149 ? 129.910 110.362 136.440 1.00 68.82  ? 149 LEU A CB   1 
ATOM   3196 C CG   . LEU B  1 149 ? 131.401 110.312 136.106 1.00 66.69  ? 149 LEU A CG   1 
ATOM   3197 C CD1  . LEU B  1 149 ? 131.839 108.885 135.843 1.00 69.43  ? 149 LEU A CD1  1 
ATOM   3198 C CD2  . LEU B  1 149 ? 131.710 111.197 134.915 1.00 70.28  ? 149 LEU A CD2  1 
ATOM   3199 N N    . ILE B  1 150 ? 130.048 111.193 139.469 1.00 76.98  ? 150 ILE A N    1 
ATOM   3200 C CA   . ILE B  1 150 ? 130.831 111.633 140.620 1.00 71.88  ? 150 ILE A CA   1 
ATOM   3201 C C    . ILE B  1 150 ? 130.669 110.653 141.777 1.00 72.36  ? 150 ILE A C    1 
ATOM   3202 O O    . ILE B  1 150 ? 131.645 110.286 142.447 1.00 76.29  ? 150 ILE A O    1 
ATOM   3203 C CB   . ILE B  1 150 ? 130.435 113.060 141.031 1.00 68.96  ? 150 ILE A CB   1 
ATOM   3204 C CG1  . ILE B  1 150 ? 130.755 114.041 139.906 1.00 67.57  ? 150 ILE A CG1  1 
ATOM   3205 C CG2  . ILE B  1 150 ? 131.162 113.464 142.298 1.00 65.81  ? 150 ILE A CG2  1 
ATOM   3206 C CD1  . ILE B  1 150 ? 130.444 115.476 140.248 1.00 72.13  ? 150 ILE A CD1  1 
ATOM   3207 N N    . THR B  1 151 ? 129.435 110.201 142.023 1.00 81.43  ? 151 THR A N    1 
ATOM   3208 C CA   . THR B  1 151 ? 129.212 109.273 143.128 1.00 80.30  ? 151 THR A CA   1 
ATOM   3209 C C    . THR B  1 151 ? 129.970 107.965 142.916 1.00 82.67  ? 151 THR A C    1 
ATOM   3210 O O    . THR B  1 151 ? 130.586 107.437 143.853 1.00 84.74  ? 151 THR A O    1 
ATOM   3211 C CB   . THR B  1 151 ? 127.720 108.998 143.302 1.00 83.05  ? 151 THR A CB   1 
ATOM   3212 O OG1  . THR B  1 151 ? 127.045 110.220 143.628 1.00 85.18  ? 151 THR A OG1  1 
ATOM   3213 C CG2  . THR B  1 151 ? 127.495 107.989 144.412 1.00 81.54  ? 151 THR A CG2  1 
ATOM   3214 N N    . ILE B  1 152 ? 129.941 107.431 141.695 1.00 88.95  ? 152 ILE A N    1 
ATOM   3215 C CA   . ILE B  1 152 ? 130.608 106.157 141.445 1.00 87.24  ? 152 ILE A CA   1 
ATOM   3216 C C    . ILE B  1 152 ? 132.119 106.313 141.539 1.00 86.65  ? 152 ILE A C    1 
ATOM   3217 O O    . ILE B  1 152 ? 132.820 105.412 142.015 1.00 83.80  ? 152 ILE A O    1 
ATOM   3218 C CB   . ILE B  1 152 ? 130.181 105.583 140.083 1.00 85.21  ? 152 ILE A CB   1 
ATOM   3219 C CG1  . ILE B  1 152 ? 130.709 104.158 139.918 1.00 82.72  ? 152 ILE A CG1  1 
ATOM   3220 C CG2  . ILE B  1 152 ? 130.687 106.460 138.954 1.00 85.23  ? 152 ILE A CG2  1 
ATOM   3221 C CD1  . ILE B  1 152 ? 129.823 103.108 140.539 1.00 86.99  ? 152 ILE A CD1  1 
ATOM   3222 N N    . ILE B  1 153 ? 132.651 107.458 141.103 1.00 92.25  ? 153 ILE A N    1 
ATOM   3223 C CA   . ILE B  1 153 ? 134.083 107.706 141.259 1.00 87.43  ? 153 ILE A CA   1 
ATOM   3224 C C    . ILE B  1 153 ? 134.458 107.708 142.733 1.00 87.56  ? 153 ILE A C    1 
ATOM   3225 O O    . ILE B  1 153 ? 135.460 107.110 143.142 1.00 88.62  ? 153 ILE A O    1 
ATOM   3226 C CB   . ILE B  1 153 ? 134.481 109.025 140.578 1.00 82.45  ? 153 ILE A CB   1 
ATOM   3227 C CG1  . ILE B  1 153 ? 134.159 108.983 139.084 1.00 85.87  ? 153 ILE A CG1  1 
ATOM   3228 C CG2  . ILE B  1 153 ? 135.954 109.312 140.800 1.00 82.21  ? 153 ILE A CG2  1 
ATOM   3229 C CD1  . ILE B  1 153 ? 134.737 110.143 138.309 1.00 84.59  ? 153 ILE A CD1  1 
ATOM   3230 N N    . ALA B  1 154 ? 133.656 108.390 143.555 1.00 103.71 ? 154 ALA A N    1 
ATOM   3231 C CA   . ALA B  1 154 ? 133.942 108.431 144.983 1.00 101.19 ? 154 ALA A CA   1 
ATOM   3232 C C    . ALA B  1 154 ? 133.904 107.035 145.594 1.00 101.25 ? 154 ALA A C    1 
ATOM   3233 O O    . ALA B  1 154 ? 134.777 106.671 146.393 1.00 103.12 ? 154 ALA A O    1 
ATOM   3234 C CB   . ALA B  1 154 ? 132.953 109.350 145.697 1.00 100.62 ? 154 ALA A CB   1 
ATOM   3235 N N    . TYR B  1 155 ? 132.906 106.235 145.222 1.00 108.87 ? 155 TYR A N    1 
ATOM   3236 C CA   . TYR B  1 155 ? 132.810 104.884 145.768 1.00 109.38 ? 155 TYR A CA   1 
ATOM   3237 C C    . TYR B  1 155 ? 134.008 104.038 145.361 1.00 112.59 ? 155 TYR A C    1 
ATOM   3238 O O    . TYR B  1 155 ? 134.568 103.301 146.184 1.00 113.20 ? 155 TYR A O    1 
ATOM   3239 C CB   . TYR B  1 155 ? 131.513 104.216 145.317 1.00 110.09 ? 155 TYR A CB   1 
ATOM   3240 C CG   . TYR B  1 155 ? 131.387 102.780 145.768 1.00 113.04 ? 155 TYR A CG   1 
ATOM   3241 C CD1  . TYR B  1 155 ? 131.041 102.469 147.076 1.00 112.29 ? 155 TYR A CD1  1 
ATOM   3242 C CD2  . TYR B  1 155 ? 131.630 101.733 144.887 1.00 113.78 ? 155 TYR A CD2  1 
ATOM   3243 C CE1  . TYR B  1 155 ? 130.928 101.157 147.491 1.00 113.21 ? 155 TYR A CE1  1 
ATOM   3244 C CE2  . TYR B  1 155 ? 131.520 100.417 145.295 1.00 112.85 ? 155 TYR A CE2  1 
ATOM   3245 C CZ   . TYR B  1 155 ? 131.169 100.136 146.597 1.00 113.53 ? 155 TYR A CZ   1 
ATOM   3246 O OH   . TYR B  1 155 ? 131.057 98.828  147.007 1.00 113.55 ? 155 TYR A OH   1 
ATOM   3247 N N    . ILE B  1 156 ? 134.419 104.125 144.094 1.00 112.12 ? 156 ILE A N    1 
ATOM   3248 C CA   . ILE B  1 156 ? 135.566 103.348 143.637 1.00 109.49 ? 156 ILE A CA   1 
ATOM   3249 C C    . ILE B  1 156 ? 136.821 103.753 144.393 1.00 109.65 ? 156 ILE A C    1 
ATOM   3250 O O    . ILE B  1 156 ? 137.609 102.902 144.819 1.00 107.42 ? 156 ILE A O    1 
ATOM   3251 C CB   . ILE B  1 156 ? 135.753 103.498 142.117 1.00 110.79 ? 156 ILE A CB   1 
ATOM   3252 C CG1  . ILE B  1 156 ? 134.748 102.627 141.362 1.00 112.72 ? 156 ILE A CG1  1 
ATOM   3253 C CG2  . ILE B  1 156 ? 137.175 103.138 141.720 1.00 109.70 ? 156 ILE A CG2  1 
ATOM   3254 C CD1  . ILE B  1 156 ? 134.950 102.629 139.865 1.00 110.87 ? 156 ILE A CD1  1 
ATOM   3255 N N    . MET B  1 157 ? 137.035 105.060 144.562 1.00 125.24 ? 157 MET A N    1 
ATOM   3256 C CA   . MET B  1 157 ? 138.229 105.516 145.266 1.00 124.03 ? 157 MET A CA   1 
ATOM   3257 C C    . MET B  1 157 ? 138.228 105.043 146.715 1.00 124.86 ? 157 MET A C    1 
ATOM   3258 O O    . MET B  1 157 ? 139.257 104.585 147.228 1.00 126.79 ? 157 MET A O    1 
ATOM   3259 C CB   . MET B  1 157 ? 138.330 107.038 145.197 1.00 123.61 ? 157 MET A CB   1 
ATOM   3260 C CG   . MET B  1 157 ? 139.755 107.566 145.246 1.00 125.60 ? 157 MET A CG   1 
ATOM   3261 S SD   . MET B  1 157 ? 139.986 109.032 144.222 1.00 134.06 ? 157 MET A SD   1 
ATOM   3262 C CE   . MET B  1 157 ? 140.963 108.363 142.879 1.00 126.54 ? 157 MET A CE   1 
ATOM   3263 N N    . LYS B  1 158 ? 137.079 105.134 147.389 1.00 130.85 ? 158 LYS A N    1 
ATOM   3264 C CA   . LYS B  1 158 ? 137.010 104.683 148.775 1.00 130.65 ? 158 LYS A CA   1 
ATOM   3265 C C    . LYS B  1 158 ? 137.278 103.188 148.882 1.00 132.69 ? 158 LYS A C    1 
ATOM   3266 O O    . LYS B  1 158 ? 138.022 102.745 149.768 1.00 133.15 ? 158 LYS A O    1 
ATOM   3267 C CB   . LYS B  1 158 ? 135.646 105.028 149.370 1.00 131.31 ? 158 LYS A CB   1 
ATOM   3268 C CG   . LYS B  1 158 ? 135.494 104.651 150.835 1.00 132.72 ? 158 LYS A CG   1 
ATOM   3269 C CD   . LYS B  1 158 ? 134.763 103.328 150.990 1.00 132.98 ? 158 LYS A CD   1 
ATOM   3270 C CE   . LYS B  1 158 ? 134.446 103.040 152.447 1.00 131.17 ? 158 LYS A CE   1 
ATOM   3271 N NZ   . LYS B  1 158 ? 133.516 104.052 153.020 1.00 131.77 ? 158 LYS A NZ   1 
ATOM   3272 N N    . SER B  1 159 ? 136.691 102.394 147.986 1.00 140.22 ? 159 SER A N    1 
ATOM   3273 C CA   . SER B  1 159 ? 136.906 100.951 148.034 1.00 141.40 ? 159 SER A CA   1 
ATOM   3274 C C    . SER B  1 159 ? 138.363 100.603 147.760 1.00 141.97 ? 159 SER A C    1 
ATOM   3275 O O    . SER B  1 159 ? 138.934 99.722  148.414 1.00 141.41 ? 159 SER A O    1 
ATOM   3276 C CB   . SER B  1 159 ? 135.988 100.247 147.038 1.00 140.96 ? 159 SER A CB   1 
ATOM   3277 O OG   . SER B  1 159 ? 136.172 98.844  147.078 1.00 141.84 ? 159 SER A OG   1 
ATOM   3278 N N    . CYS B  1 160 ? 138.984 101.283 146.794 1.00 152.02 ? 160 CYS A N    1 
ATOM   3279 C CA   . CYS B  1 160 ? 140.387 101.021 146.494 1.00 152.74 ? 160 CYS A CA   1 
ATOM   3280 C C    . CYS B  1 160 ? 141.276 101.373 147.677 1.00 153.76 ? 160 CYS A C    1 
ATOM   3281 O O    . CYS B  1 160 ? 142.201 100.623 148.009 1.00 154.15 ? 160 CYS A O    1 
ATOM   3282 C CB   . CYS B  1 160 ? 140.814 101.801 145.250 1.00 153.59 ? 160 CYS A CB   1 
ATOM   3283 S SG   . CYS B  1 160 ? 142.539 101.546 144.766 1.00 153.41 ? 160 CYS A SG   1 
ATOM   3284 N N    . HIS B  1 161 ? 141.013 102.507 148.330 1.00 156.62 ? 161 HIS A N    1 
ATOM   3285 C CA   . HIS B  1 161 ? 141.800 102.867 149.505 1.00 156.27 ? 161 HIS A CA   1 
ATOM   3286 C C    . HIS B  1 161 ? 141.621 101.844 150.620 1.00 156.35 ? 161 HIS A C    1 
ATOM   3287 O O    . HIS B  1 161 ? 142.593 101.455 151.279 1.00 155.09 ? 161 HIS A O    1 
ATOM   3288 C CB   . HIS B  1 161 ? 141.419 104.263 149.997 1.00 157.06 ? 161 HIS A CB   1 
ATOM   3289 C CG   . HIS B  1 161 ? 142.162 104.690 151.225 1.00 158.86 ? 161 HIS A CG   1 
ATOM   3290 N ND1  . HIS B  1 161 ? 141.756 104.355 152.496 1.00 158.07 ? 161 HIS A ND1  1 
ATOM   3291 C CD2  . HIS B  1 161 ? 143.291 105.428 151.370 1.00 157.91 ? 161 HIS A CD2  1 
ATOM   3292 C CE1  . HIS B  1 161 ? 142.600 104.867 153.375 1.00 156.67 ? 161 HIS A CE1  1 
ATOM   3293 N NE2  . HIS B  1 161 ? 143.539 105.522 152.717 1.00 157.57 ? 161 HIS A NE2  1 
ATOM   3294 N N    . GLN B  1 162 ? 140.384 101.393 150.844 1.00 159.46 ? 162 GLN A N    1 
ATOM   3295 C CA   . GLN B  1 162 ? 140.146 100.408 151.890 1.00 159.41 ? 162 GLN A CA   1 
ATOM   3296 C C    . GLN B  1 162 ? 140.876 99.102  151.592 1.00 160.84 ? 162 GLN A C    1 
ATOM   3297 O O    . GLN B  1 162 ? 141.472 98.499  152.489 1.00 161.02 ? 162 GLN A O    1 
ATOM   3298 C CB   . GLN B  1 162 ? 138.646 100.158 152.053 1.00 158.75 ? 162 GLN A CB   1 
ATOM   3299 C CG   . GLN B  1 162 ? 138.278 99.361  153.294 1.00 158.58 ? 162 GLN A CG   1 
ATOM   3300 C CD   . GLN B  1 162 ? 138.380 97.864  153.079 1.00 159.90 ? 162 GLN A CD   1 
ATOM   3301 O OE1  . GLN B  1 162 ? 138.416 97.388  151.945 1.00 160.01 ? 162 GLN A OE1  1 
ATOM   3302 N NE2  . GLN B  1 162 ? 138.421 97.110  154.172 1.00 160.39 ? 162 GLN A NE2  1 
ATOM   3303 N N    . ARG B  1 163 ? 140.842 98.653  150.335 1.00 166.39 ? 163 ARG A N    1 
ATOM   3304 C CA   . ARG B  1 163 ? 141.533 97.417  149.981 1.00 166.48 ? 163 ARG A CA   1 
ATOM   3305 C C    . ARG B  1 163 ? 143.042 97.568  150.119 1.00 166.43 ? 163 ARG A C    1 
ATOM   3306 O O    . ARG B  1 163 ? 143.723 96.653  150.595 1.00 164.59 ? 163 ARG A O    1 
ATOM   3307 C CB   . ARG B  1 163 ? 141.163 96.992  148.560 1.00 166.04 ? 163 ARG A CB   1 
ATOM   3308 C CG   . ARG B  1 163 ? 141.699 95.624  148.175 1.00 165.75 ? 163 ARG A CG   1 
ATOM   3309 C CD   . ARG B  1 163 ? 141.353 95.272  146.738 1.00 166.59 ? 163 ARG A CD   1 
ATOM   3310 N NE   . ARG B  1 163 ? 142.016 96.152  145.784 1.00 167.71 ? 163 ARG A NE   1 
ATOM   3311 C CZ   . ARG B  1 163 ? 143.225 95.935  145.282 1.00 167.30 ? 163 ARG A CZ   1 
ATOM   3312 N NH1  . ARG B  1 163 ? 143.933 94.870  145.621 1.00 166.84 ? 163 ARG A NH1  1 
ATOM   3313 N NH2  . ARG B  1 163 ? 143.733 96.808  144.418 1.00 165.92 ? 163 ARG A NH2  1 
ATOM   3314 N N    . GLN B  1 164 ? 143.570 98.735  149.775 1.00 168.39 ? 164 GLN A N    1 
ATOM   3315 C CA   . GLN B  1 164 ? 145.043 98.903  149.842 1.00 167.50 ? 164 GLN A CA   1 
ATOM   3316 C C    . GLN B  1 164 ? 145.429 98.917  151.318 1.00 168.51 ? 164 GLN A C    1 
ATOM   3317 O O    . GLN B  1 164 ? 146.502 98.393  151.654 1.00 167.93 ? 164 GLN A O    1 
ATOM   3318 C CB   . GLN B  1 164 ? 145.486 100.205 149.177 1.00 167.26 ? 164 GLN A CB   1 
ATOM   3319 C CG   . GLN B  1 164 ? 146.661 100.043 148.226 1.00 167.67 ? 164 GLN A CG   1 
ATOM   3320 C CD   . GLN B  1 164 ? 146.680 101.145 147.196 1.00 168.91 ? 164 GLN A CD   1 
ATOM   3321 O OE1  . GLN B  1 164 ? 146.292 102.279 147.469 1.00 168.91 ? 164 GLN A OE1  1 
ATOM   3322 N NE2  . GLN B  1 164 ? 147.127 100.816 145.996 1.00 168.79 ? 164 GLN A NE2  1 
ATOM   3323 N N    . LEU B  1 165 ? 144.579 99.515  152.155 1.00 167.03 ? 165 LEU A N    1 
ATOM   3324 C CA   . LEU B  1 165 ? 144.926 99.607  153.570 1.00 165.77 ? 165 LEU A CA   1 
ATOM   3325 C C    . LEU B  1 165 ? 145.187 98.229  154.165 1.00 165.43 ? 165 LEU A C    1 
ATOM   3326 O O    . LEU B  1 165 ? 146.143 98.044  154.924 1.00 164.28 ? 165 LEU A O    1 
ATOM   3327 C CB   . LEU B  1 165 ? 143.818 100.326 154.337 1.00 164.73 ? 165 LEU A CB   1 
ATOM   3328 C CG   . LEU B  1 165 ? 144.104 100.623 155.810 1.00 164.68 ? 165 LEU A CG   1 
ATOM   3329 C CD1  . LEU B  1 165 ? 143.503 101.961 156.212 1.00 164.93 ? 165 LEU A CD1  1 
ATOM   3330 C CD2  . LEU B  1 165 ? 143.573 99.503  156.696 1.00 163.98 ? 165 LEU A CD2  1 
ATOM   3331 N N    . ARG B  1 166 ? 144.342 97.251  153.835 1.00 167.44 ? 166 ARG A N    1 
ATOM   3332 C CA   . ARG B  1 166 ? 144.485 95.890  154.351 1.00 167.02 ? 166 ARG A CA   1 
ATOM   3333 C C    . ARG B  1 166 ? 145.459 95.129  153.455 1.00 167.14 ? 166 ARG A C    1 
ATOM   3334 O O    . ARG B  1 166 ? 145.082 94.304  152.620 1.00 166.58 ? 166 ARG A O    1 
ATOM   3335 C CB   . ARG B  1 166 ? 143.127 95.201  154.433 1.00 166.32 ? 166 ARG A CB   1 
ATOM   3336 C CG   . ARG B  1 166 ? 143.162 93.836  155.099 1.00 165.44 ? 166 ARG A CG   1 
ATOM   3337 C CD   . ARG B  1 166 ? 141.759 93.280  155.278 1.00 165.49 ? 166 ARG A CD   1 
ATOM   3338 N NE   . ARG B  1 166 ? 141.029 93.207  154.017 1.00 165.80 ? 166 ARG A NE   1 
ATOM   3339 C CZ   . ARG B  1 166 ? 141.052 92.163  153.198 1.00 165.58 ? 166 ARG A CZ   1 
ATOM   3340 N NH1  . ARG B  1 166 ? 141.758 91.080  153.475 1.00 165.02 ? 166 ARG A NH1  1 
ATOM   3341 N NH2  . ARG B  1 166 ? 140.344 92.209  152.074 1.00 165.31 ? 166 ARG A NH2  1 
ATOM   3342 N N    . ARG B  1 167 ? 146.742 95.418  153.646 1.00 170.11 ? 167 ARG A N    1 
ATOM   3343 C CA   . ARG B  1 167 ? 147.800 94.790  152.862 1.00 169.69 ? 167 ARG A CA   1 
ATOM   3344 C C    . ARG B  1 167 ? 148.784 94.053  153.763 1.00 168.52 ? 167 ARG A C    1 
ATOM   3345 O O    . ARG B  1 167 ? 149.500 94.668  154.548 1.00 168.49 ? 167 ARG A O    1 
ATOM   3346 C CB   . ARG B  1 167 ? 148.535 95.838  152.024 1.00 169.12 ? 167 ARG A CB   1 
ATOM   3347 C CG   . ARG B  1 167 ? 149.777 95.313  151.317 1.00 168.26 ? 167 ARG A CG   1 
ATOM   3348 C CD   . ARG B  1 167 ? 149.424 94.272  150.268 1.00 167.68 ? 167 ARG A CD   1 
ATOM   3349 N NE   . ARG B  1 167 ? 148.627 94.835  149.186 1.00 168.28 ? 167 ARG A NE   1 
ATOM   3350 C CZ   . ARG B  1 167 ? 148.261 94.170  148.100 1.00 169.01 ? 167 ARG A CZ   1 
ATOM   3351 N NH1  . ARG B  1 167 ? 148.606 92.906  147.913 1.00 168.50 ? 167 ARG A NH1  1 
ATOM   3352 N NH2  . ARG B  1 167 ? 147.529 94.788  147.175 1.00 169.63 ? 167 ARG A NH2  1 
ATOM   3353 N N    . ALA B  1 188 ? 130.787 108.552 150.804 1.00 132.96 ? 188 ALA A N    1 
ATOM   3354 C CA   . ALA B  1 188 ? 130.392 109.450 151.883 1.00 135.13 ? 188 ALA A CA   1 
ATOM   3355 C C    . ALA B  1 188 ? 131.275 110.693 151.915 1.00 136.23 ? 188 ALA A C    1 
ATOM   3356 O O    . ALA B  1 188 ? 131.013 111.675 151.222 1.00 134.64 ? 188 ALA A O    1 
ATOM   3357 C CB   . ALA B  1 188 ? 130.441 108.726 153.220 1.00 132.11 ? 188 ALA A CB   1 
ATOM   3358 N N    . GLY B  1 189 ? 132.329 110.644 152.728 1.00 135.64 ? 189 GLY A N    1 
ATOM   3359 C CA   . GLY B  1 189 ? 133.241 111.761 152.862 1.00 133.61 ? 189 GLY A CA   1 
ATOM   3360 C C    . GLY B  1 189 ? 134.475 111.633 151.994 1.00 132.07 ? 189 GLY A C    1 
ATOM   3361 O O    . GLY B  1 189 ? 135.488 112.296 152.242 1.00 131.98 ? 189 GLY A O    1 
ATOM   3362 N N    . TRP B  1 190 ? 134.404 110.781 150.975 1.00 129.62 ? 190 TRP A N    1 
ATOM   3363 C CA   . TRP B  1 190 ? 135.520 110.521 150.074 1.00 130.82 ? 190 TRP A CA   1 
ATOM   3364 C C    . TRP B  1 190 ? 135.316 111.195 148.719 1.00 130.63 ? 190 TRP A C    1 
ATOM   3365 O O    . TRP B  1 190 ? 135.690 110.653 147.677 1.00 131.84 ? 190 TRP A O    1 
ATOM   3366 C CB   . TRP B  1 190 ? 135.721 109.019 149.890 1.00 131.74 ? 190 TRP A CB   1 
ATOM   3367 C CG   . TRP B  1 190 ? 135.950 108.270 151.166 1.00 133.08 ? 190 TRP A CG   1 
ATOM   3368 C CD1  . TRP B  1 190 ? 135.007 107.903 152.078 1.00 134.01 ? 190 TRP A CD1  1 
ATOM   3369 C CD2  . TRP B  1 190 ? 137.201 107.782 151.665 1.00 134.15 ? 190 TRP A CD2  1 
ATOM   3370 N NE1  . TRP B  1 190 ? 135.594 107.226 153.121 1.00 133.67 ? 190 TRP A NE1  1 
ATOM   3371 C CE2  . TRP B  1 190 ? 136.942 107.137 152.889 1.00 134.47 ? 190 TRP A CE2  1 
ATOM   3372 C CE3  . TRP B  1 190 ? 138.518 107.834 151.197 1.00 133.15 ? 190 TRP A CE3  1 
ATOM   3373 C CZ2  . TRP B  1 190 ? 137.944 106.546 153.651 1.00 133.46 ? 190 TRP A CZ2  1 
ATOM   3374 C CZ3  . TRP B  1 190 ? 139.515 107.244 151.953 1.00 133.25 ? 190 TRP A CZ3  1 
ATOM   3375 C CH2  . TRP B  1 190 ? 139.223 106.611 153.167 1.00 133.35 ? 190 TRP A CH2  1 
ATOM   3376 N N    . LYS B  1 191 ? 134.730 112.382 148.718 1.00 114.44 ? 191 LYS A N    1 
ATOM   3377 C CA   . LYS B  1 191 ? 134.455 113.068 147.463 1.00 114.76 ? 191 LYS A CA   1 
ATOM   3378 C C    . LYS B  1 191 ? 135.757 113.518 146.814 1.00 116.32 ? 191 LYS A C    1 
ATOM   3379 O O    . LYS B  1 191 ? 136.551 114.221 147.448 1.00 118.40 ? 191 LYS A O    1 
ATOM   3380 C CB   . LYS B  1 191 ? 133.543 114.268 147.699 1.00 116.27 ? 191 LYS A CB   1 
ATOM   3381 C CG   . LYS B  1 191 ? 132.144 113.913 148.172 1.00 118.21 ? 191 LYS A CG   1 
ATOM   3382 C CD   . LYS B  1 191 ? 131.344 113.227 147.080 1.00 116.35 ? 191 LYS A CD   1 
ATOM   3383 C CE   . LYS B  1 191 ? 129.913 112.973 147.527 1.00 116.47 ? 191 LYS A CE   1 
ATOM   3384 N NZ   . LYS B  1 191 ? 129.102 112.323 146.464 1.00 113.36 ? 191 LYS A NZ   1 
ATOM   3385 N N    . PRO B  1 192 ? 136.014 113.145 145.562 1.00 108.16 ? 192 PRO A N    1 
ATOM   3386 C CA   . PRO B  1 192 ? 137.239 113.595 144.893 1.00 107.19 ? 192 PRO A CA   1 
ATOM   3387 C C    . PRO B  1 192 ? 137.184 115.080 144.569 1.00 107.77 ? 192 PRO A C    1 
ATOM   3388 O O    . PRO B  1 192 ? 136.119 115.687 144.460 1.00 109.25 ? 192 PRO A O    1 
ATOM   3389 C CB   . PRO B  1 192 ? 137.270 112.751 143.615 1.00 104.99 ? 192 PRO A CB   1 
ATOM   3390 C CG   . PRO B  1 192 ? 135.836 112.456 143.343 1.00 105.03 ? 192 PRO A CG   1 
ATOM   3391 C CD   . PRO B  1 192 ? 135.185 112.296 144.689 1.00 105.91 ? 192 PRO A CD   1 
ATOM   3392 N N    . SER B  1 193 ? 138.370 115.665 144.415 1.00 103.49 ? 193 SER A N    1 
ATOM   3393 C CA   . SER B  1 193 ? 138.474 117.078 144.088 1.00 101.24 ? 193 SER A CA   1 
ATOM   3394 C C    . SER B  1 193 ? 138.160 117.311 142.613 1.00 103.88 ? 193 SER A C    1 
ATOM   3395 O O    . SER B  1 193 ? 137.995 116.378 141.823 1.00 109.32 ? 193 SER A O    1 
ATOM   3396 C CB   . SER B  1 193 ? 139.868 117.603 144.430 1.00 100.83 ? 193 SER A CB   1 
ATOM   3397 O OG   . SER B  1 193 ? 140.861 116.947 143.669 1.00 103.52 ? 193 SER A OG   1 
ATOM   3398 N N    . VAL B  1 194 ? 138.085 118.590 142.241 1.00 87.70  ? 194 VAL A N    1 
ATOM   3399 C CA   . VAL B  1 194 ? 137.695 118.953 140.881 1.00 89.53  ? 194 VAL A CA   1 
ATOM   3400 C C    . VAL B  1 194 ? 138.770 118.548 139.881 1.00 96.83  ? 194 VAL A C    1 
ATOM   3401 O O    . VAL B  1 194 ? 138.469 118.146 138.752 1.00 102.32 ? 194 VAL A O    1 
ATOM   3402 C CB   . VAL B  1 194 ? 137.385 120.457 140.803 1.00 89.73  ? 194 VAL A CB   1 
ATOM   3403 C CG1  . VAL B  1 194 ? 136.974 120.835 139.391 1.00 93.08  ? 194 VAL A CG1  1 
ATOM   3404 C CG2  . VAL B  1 194 ? 136.296 120.820 141.794 1.00 92.04  ? 194 VAL A CG2  1 
ATOM   3405 N N    . TYR B  1 195 ? 140.041 118.665 140.271 1.00 100.84 ? 195 TYR A N    1 
ATOM   3406 C CA   . TYR B  1 195 ? 141.134 118.394 139.344 1.00 103.76 ? 195 TYR A CA   1 
ATOM   3407 C C    . TYR B  1 195 ? 141.102 116.951 138.846 1.00 106.64 ? 195 TYR A C    1 
ATOM   3408 O O    . TYR B  1 195 ? 141.257 116.694 137.642 1.00 109.82 ? 195 TYR A O    1 
ATOM   3409 C CB   . TYR B  1 195 ? 142.464 118.709 140.028 1.00 102.54 ? 195 TYR A CB   1 
ATOM   3410 C CG   . TYR B  1 195 ? 143.624 118.939 139.087 1.00 107.41 ? 195 TYR A CG   1 
ATOM   3411 C CD1  . TYR B  1 195 ? 143.642 120.032 138.234 1.00 108.41 ? 195 TYR A CD1  1 
ATOM   3412 C CD2  . TYR B  1 195 ? 144.712 118.077 139.074 1.00 105.49 ? 195 TYR A CD2  1 
ATOM   3413 C CE1  . TYR B  1 195 ? 144.705 120.251 137.380 1.00 109.90 ? 195 TYR A CE1  1 
ATOM   3414 C CE2  . TYR B  1 195 ? 145.778 118.287 138.221 1.00 102.83 ? 195 TYR A CE2  1 
ATOM   3415 C CZ   . TYR B  1 195 ? 145.769 119.376 137.378 1.00 108.33 ? 195 TYR A CZ   1 
ATOM   3416 O OH   . TYR B  1 195 ? 146.832 119.591 136.529 1.00 110.20 ? 195 TYR A OH   1 
ATOM   3417 N N    . TYR B  1 196 ? 140.892 115.997 139.751 1.00 93.71  ? 196 TYR A N    1 
ATOM   3418 C CA   . TYR B  1 196 ? 140.860 114.598 139.342 1.00 94.15  ? 196 TYR A CA   1 
ATOM   3419 C C    . TYR B  1 196 ? 139.656 114.308 138.458 1.00 97.67  ? 196 TYR A C    1 
ATOM   3420 O O    . TYR B  1 196 ? 139.755 113.528 137.503 1.00 103.16 ? 196 TYR A O    1 
ATOM   3421 C CB   . TYR B  1 196 ? 140.861 113.688 140.569 1.00 97.44  ? 196 TYR A CB   1 
ATOM   3422 C CG   . TYR B  1 196 ? 142.194 113.632 141.279 1.00 102.81 ? 196 TYR A CG   1 
ATOM   3423 C CD1  . TYR B  1 196 ? 143.313 114.247 140.742 1.00 99.70  ? 196 TYR A CD1  1 
ATOM   3424 C CD2  . TYR B  1 196 ? 142.333 112.952 142.483 1.00 102.88 ? 196 TYR A CD2  1 
ATOM   3425 C CE1  . TYR B  1 196 ? 144.533 114.198 141.383 1.00 98.55  ? 196 TYR A CE1  1 
ATOM   3426 C CE2  . TYR B  1 196 ? 143.551 112.895 143.132 1.00 100.70 ? 196 TYR A CE2  1 
ATOM   3427 C CZ   . TYR B  1 196 ? 144.648 113.519 142.578 1.00 100.96 ? 196 TYR A CZ   1 
ATOM   3428 O OH   . TYR B  1 196 ? 145.862 113.468 143.219 1.00 104.65 ? 196 TYR A OH   1 
ATOM   3429 N N    . VAL B  1 197 ? 138.512 114.925 138.758 1.00 81.18  ? 197 VAL A N    1 
ATOM   3430 C CA   . VAL B  1 197 ? 137.337 114.741 137.910 1.00 79.33  ? 197 VAL A CA   1 
ATOM   3431 C C    . VAL B  1 197 ? 137.611 115.261 136.507 1.00 82.85  ? 197 VAL A C    1 
ATOM   3432 O O    . VAL B  1 197 ? 137.248 114.629 135.508 1.00 87.41  ? 197 VAL A O    1 
ATOM   3433 C CB   . VAL B  1 197 ? 136.109 115.424 138.538 1.00 76.29  ? 197 VAL A CB   1 
ATOM   3434 C CG1  . VAL B  1 197 ? 134.909 115.292 137.625 1.00 80.47  ? 197 VAL A CG1  1 
ATOM   3435 C CG2  . VAL B  1 197 ? 135.810 114.827 139.899 1.00 83.01  ? 197 VAL A CG2  1 
ATOM   3436 N N    . MET B  1 198 ? 138.258 116.426 136.406 1.00 83.55  ? 198 MET A N    1 
ATOM   3437 C CA   . MET B  1 198 ? 138.584 116.973 135.095 1.00 84.49  ? 198 MET A CA   1 
ATOM   3438 C C    . MET B  1 198 ? 139.532 116.055 134.333 1.00 86.67  ? 198 MET A C    1 
ATOM   3439 O O    . MET B  1 198 ? 139.347 115.819 133.133 1.00 92.85  ? 198 MET A O    1 
ATOM   3440 C CB   . MET B  1 198 ? 139.188 118.367 135.248 1.00 85.15  ? 198 MET A CB   1 
ATOM   3441 C CG   . MET B  1 198 ? 139.317 119.134 133.946 1.00 86.98  ? 198 MET A CG   1 
ATOM   3442 S SD   . MET B  1 198 ? 140.114 120.736 134.164 1.00 99.09  ? 198 MET A SD   1 
ATOM   3443 C CE   . MET B  1 198 ? 141.827 120.243 134.305 1.00 90.27  ? 198 MET A CE   1 
ATOM   3444 N N    . LEU B  1 199 ? 140.553 115.524 135.011 1.00 81.94  ? 199 LEU A N    1 
ATOM   3445 C CA   . LEU B  1 199 ? 141.481 114.624 134.332 1.00 82.81  ? 199 LEU A CA   1 
ATOM   3446 C C    . LEU B  1 199 ? 140.778 113.361 133.849 1.00 87.68  ? 199 LEU A C    1 
ATOM   3447 O O    . LEU B  1 199 ? 141.008 112.902 132.720 1.00 90.98  ? 199 LEU A O    1 
ATOM   3448 C CB   . LEU B  1 199 ? 142.643 114.267 135.257 1.00 79.45  ? 199 LEU A CB   1 
ATOM   3449 C CG   . LEU B  1 199 ? 143.581 115.416 135.628 1.00 84.48  ? 199 LEU A CG   1 
ATOM   3450 C CD1  . LEU B  1 199 ? 144.798 114.888 136.371 1.00 85.06  ? 199 LEU A CD1  1 
ATOM   3451 C CD2  . LEU B  1 199 ? 143.996 116.189 134.391 1.00 84.51  ? 199 LEU A CD2  1 
ATOM   3452 N N    . ILE B  1 200 ? 139.911 112.786 134.684 1.00 78.17  ? 200 ILE A N    1 
ATOM   3453 C CA   . ILE B  1 200 ? 139.189 111.580 134.293 1.00 71.55  ? 200 ILE A CA   1 
ATOM   3454 C C    . ILE B  1 200 ? 138.292 111.859 133.096 1.00 73.53  ? 200 ILE A C    1 
ATOM   3455 O O    . ILE B  1 200 ? 138.224 111.062 132.152 1.00 78.87  ? 200 ILE A O    1 
ATOM   3456 C CB   . ILE B  1 200 ? 138.388 111.029 135.485 1.00 69.09  ? 200 ILE A CB   1 
ATOM   3457 C CG1  . ILE B  1 200 ? 139.334 110.424 136.523 1.00 73.24  ? 200 ILE A CG1  1 
ATOM   3458 C CG2  . ILE B  1 200 ? 137.376 110.002 135.011 1.00 68.64  ? 200 ILE A CG2  1 
ATOM   3459 C CD1  . ILE B  1 200 ? 138.629 109.867 137.738 1.00 72.16  ? 200 ILE A CD1  1 
ATOM   3460 N N    . LEU B  1 201 ? 137.583 112.990 133.116 1.00 68.77  ? 201 LEU A N    1 
ATOM   3461 C CA   . LEU B  1 201 ? 136.712 113.323 131.994 1.00 69.53  ? 201 LEU A CA   1 
ATOM   3462 C C    . LEU B  1 201 ? 137.507 113.527 130.714 1.00 74.28  ? 201 LEU A C    1 
ATOM   3463 O O    . LEU B  1 201 ? 137.086 113.082 129.639 1.00 77.14  ? 201 LEU A O    1 
ATOM   3464 C CB   . LEU B  1 201 ? 135.889 114.569 132.320 1.00 68.40  ? 201 LEU A CB   1 
ATOM   3465 C CG   . LEU B  1 201 ? 134.668 114.344 133.207 1.00 65.70  ? 201 LEU A CG   1 
ATOM   3466 C CD1  . LEU B  1 201 ? 134.003 115.661 133.546 1.00 68.76  ? 201 LEU A CD1  1 
ATOM   3467 C CD2  . LEU B  1 201 ? 133.685 113.417 132.515 1.00 65.03  ? 201 LEU A CD2  1 
ATOM   3468 N N    . CYS B  1 202 ? 138.661 114.190 130.800 1.00 84.60  ? 202 CYS A N    1 
ATOM   3469 C CA   . CYS B  1 202 ? 139.480 114.383 129.606 1.00 80.25  ? 202 CYS A CA   1 
ATOM   3470 C C    . CYS B  1 202 ? 139.951 113.049 129.041 1.00 81.30  ? 202 CYS A C    1 
ATOM   3471 O O    . CYS B  1 202 ? 139.889 112.820 127.826 1.00 85.62  ? 202 CYS A O    1 
ATOM   3472 C CB   . CYS B  1 202 ? 140.674 115.282 129.920 1.00 77.61  ? 202 CYS A CB   1 
ATOM   3473 S SG   . CYS B  1 202 ? 140.245 117.003 130.253 1.00 97.82  ? 202 CYS A SG   1 
ATOM   3474 N N    . THR B  1 203 ? 140.420 112.149 129.911 1.00 70.25  ? 203 THR A N    1 
ATOM   3475 C CA   . THR B  1 203 ? 140.869 110.846 129.433 1.00 68.80  ? 203 THR A CA   1 
ATOM   3476 C C    . THR B  1 203 ? 139.731 110.073 128.781 1.00 72.12  ? 203 THR A C    1 
ATOM   3477 O O    . THR B  1 203 ? 139.904 109.485 127.704 1.00 78.75  ? 203 THR A O    1 
ATOM   3478 C CB   . THR B  1 203 ? 141.472 110.042 130.586 1.00 73.99  ? 203 THR A CB   1 
ATOM   3479 O OG1  . THR B  1 203 ? 142.825 110.458 130.806 1.00 79.12  ? 203 THR A OG1  1 
ATOM   3480 C CG2  . THR B  1 203 ? 141.453 108.559 130.262 1.00 78.09  ? 203 THR A CG2  1 
ATOM   3481 N N    . ALA B  1 204 ? 138.556 110.070 129.415 1.00 71.02  ? 204 ALA A N    1 
ATOM   3482 C CA   . ALA B  1 204 ? 137.422 109.343 128.848 1.00 72.53  ? 204 ALA A CA   1 
ATOM   3483 C C    . ALA B  1 204 ? 137.006 109.926 127.507 1.00 75.64  ? 204 ALA A C    1 
ATOM   3484 O O    . ALA B  1 204 ? 136.699 109.181 126.567 1.00 78.10  ? 204 ALA A O    1 
ATOM   3485 C CB   . ALA B  1 204 ? 136.247 109.358 129.824 1.00 71.31  ? 204 ALA A CB   1 
ATOM   3486 N N    . SER B  1 205 ? 136.987 111.255 127.392 1.00 75.80  ? 205 SER A N    1 
ATOM   3487 C CA   . SER B  1 205 ? 136.593 111.877 126.134 1.00 73.45  ? 205 SER A CA   1 
ATOM   3488 C C    . SER B  1 205 ? 137.586 111.553 125.027 1.00 72.20  ? 205 SER A C    1 
ATOM   3489 O O    . SER B  1 205 ? 137.185 111.257 123.894 1.00 71.04  ? 205 SER A O    1 
ATOM   3490 C CB   . SER B  1 205 ? 136.461 113.387 126.316 1.00 69.80  ? 205 SER A CB   1 
ATOM   3491 O OG   . SER B  1 205 ? 135.956 113.993 125.142 1.00 80.03  ? 205 SER A OG   1 
ATOM   3492 N N    . ILE B  1 206 ? 138.885 111.594 125.330 1.00 74.36  ? 206 ILE A N    1 
ATOM   3493 C CA   . ILE B  1 206 ? 139.880 111.256 124.315 1.00 75.33  ? 206 ILE A CA   1 
ATOM   3494 C C    . ILE B  1 206 ? 139.721 109.809 123.872 1.00 74.07  ? 206 ILE A C    1 
ATOM   3495 O O    . ILE B  1 206 ? 139.772 109.500 122.674 1.00 77.52  ? 206 ILE A O    1 
ATOM   3496 C CB   . ILE B  1 206 ? 141.299 111.535 124.838 1.00 77.69  ? 206 ILE A CB   1 
ATOM   3497 C CG1  . ILE B  1 206 ? 141.533 113.040 124.973 1.00 77.52  ? 206 ILE A CG1  1 
ATOM   3498 C CG2  . ILE B  1 206 ? 142.333 110.912 123.924 1.00 75.21  ? 206 ILE A CG2  1 
ATOM   3499 C CD1  . ILE B  1 206 ? 142.905 113.396 125.495 1.00 78.63  ? 206 ILE A CD1  1 
ATOM   3500 N N    . LEU B  1 207 ? 139.527 108.896 124.828 1.00 71.72  ? 207 LEU A N    1 
ATOM   3501 C CA   . LEU B  1 207 ? 139.374 107.488 124.465 1.00 67.71  ? 207 LEU A CA   1 
ATOM   3502 C C    . LEU B  1 207 ? 138.135 107.267 123.609 1.00 68.51  ? 207 LEU A C    1 
ATOM   3503 O O    . LEU B  1 207 ? 138.186 106.542 122.607 1.00 74.33  ? 207 LEU A O    1 
ATOM   3504 C CB   . LEU B  1 207 ? 139.318 106.624 125.724 1.00 72.97  ? 207 LEU A CB   1 
ATOM   3505 C CG   . LEU B  1 207 ? 140.560 105.788 126.029 1.00 75.47  ? 207 LEU A CG   1 
ATOM   3506 C CD1  . LEU B  1 207 ? 141.716 106.677 126.451 1.00 76.16  ? 207 LEU A CD1  1 
ATOM   3507 C CD2  . LEU B  1 207 ? 140.257 104.757 127.102 1.00 74.51  ? 207 LEU A CD2  1 
ATOM   3508 N N    . ILE B  1 208 ? 137.016 107.890 123.975 1.00 66.87  ? 208 ILE A N    1 
ATOM   3509 C CA   . ILE B  1 208 ? 135.788 107.717 123.204 1.00 69.62  ? 208 ILE A CA   1 
ATOM   3510 C C    . ILE B  1 208 ? 135.958 108.278 121.799 1.00 76.26  ? 208 ILE A C    1 
ATOM   3511 O O    . ILE B  1 208 ? 135.531 107.662 120.814 1.00 73.34  ? 208 ILE A O    1 
ATOM   3512 C CB   . ILE B  1 208 ? 134.600 108.371 123.932 1.00 68.05  ? 208 ILE A CB   1 
ATOM   3513 C CG1  . ILE B  1 208 ? 134.139 107.495 125.094 1.00 73.90  ? 208 ILE A CG1  1 
ATOM   3514 C CG2  . ILE B  1 208 ? 133.458 108.611 122.964 1.00 63.91  ? 208 ILE A CG2  1 
ATOM   3515 C CD1  . ILE B  1 208 ? 133.261 108.214 126.087 1.00 71.53  ? 208 ILE A CD1  1 
ATOM   3516 N N    . SER B  1 209 ? 136.572 109.454 121.682 1.00 81.75  ? 209 SER A N    1 
ATOM   3517 C CA   . SER B  1 209 ? 136.759 110.053 120.366 1.00 70.29  ? 209 SER A CA   1 
ATOM   3518 C C    . SER B  1 209 ? 137.655 109.193 119.488 1.00 69.90  ? 209 SER A C    1 
ATOM   3519 O O    . SER B  1 209 ? 137.369 109.003 118.300 1.00 77.37  ? 209 SER A O    1 
ATOM   3520 C CB   . SER B  1 209 ? 137.337 111.460 120.508 1.00 72.53  ? 209 SER A CB   1 
ATOM   3521 O OG   . SER B  1 209 ? 137.465 112.081 119.247 1.00 80.72  ? 209 SER A OG   1 
ATOM   3522 N N    . CYS B  1 210 ? 138.740 108.659 120.047 1.00 76.43  ? 210 CYS A N    1 
ATOM   3523 C CA   . CYS B  1 210 ? 139.620 107.806 119.254 1.00 74.51  ? 210 CYS A CA   1 
ATOM   3524 C C    . CYS B  1 210 ? 138.913 106.523 118.829 1.00 74.36  ? 210 CYS A C    1 
ATOM   3525 O O    . CYS B  1 210 ? 139.042 106.091 117.676 1.00 74.62  ? 210 CYS A O    1 
ATOM   3526 C CB   . CYS B  1 210 ? 140.893 107.484 120.036 1.00 81.79  ? 210 CYS A CB   1 
ATOM   3527 S SG   . CYS B  1 210 ? 141.989 108.896 120.281 1.00 96.93  ? 210 CYS A SG   1 
ATOM   3528 N N    . CYS B  1 211 ? 138.153 105.905 119.735 1.00 82.77  ? 211 CYS A N    1 
ATOM   3529 C CA   . CYS B  1 211 ? 137.436 104.687 119.374 1.00 79.65  ? 211 CYS A CA   1 
ATOM   3530 C C    . CYS B  1 211 ? 136.404 104.953 118.287 1.00 78.99  ? 211 CYS A C    1 
ATOM   3531 O O    . CYS B  1 211 ? 136.247 104.149 117.362 1.00 80.61  ? 211 CYS A O    1 
ATOM   3532 C CB   . CYS B  1 211 ? 136.772 104.077 120.610 1.00 81.48  ? 211 CYS A CB   1 
ATOM   3533 S SG   . CYS B  1 211 ? 137.930 103.392 121.813 1.00 98.75  ? 211 CYS A SG   1 
ATOM   3534 N N    . ALA B  1 212 ? 135.689 106.079 118.380 1.00 72.03  ? 212 ALA A N    1 
ATOM   3535 C CA   . ALA B  1 212 ? 134.720 106.416 117.340 1.00 68.73  ? 212 ALA A CA   1 
ATOM   3536 C C    . ALA B  1 212 ? 135.402 106.688 116.007 1.00 68.76  ? 212 ALA A C    1 
ATOM   3537 O O    . ALA B  1 212 ? 134.935 106.228 114.960 1.00 67.78  ? 212 ALA A O    1 
ATOM   3538 C CB   . ALA B  1 212 ? 133.887 107.619 117.773 1.00 71.87  ? 212 ALA A CB   1 
ATOM   3539 N N    . SER B  1 213 ? 136.517 107.423 116.024 1.00 76.32  ? 213 SER A N    1 
ATOM   3540 C CA   . SER B  1 213 ? 137.221 107.718 114.786 1.00 66.08  ? 213 SER A CA   1 
ATOM   3541 C C    . SER B  1 213 ? 137.878 106.487 114.188 1.00 68.80  ? 213 SER A C    1 
ATOM   3542 O O    . SER B  1 213 ? 138.199 106.490 112.995 1.00 67.35  ? 213 SER A O    1 
ATOM   3543 C CB   . SER B  1 213 ? 138.276 108.798 115.028 1.00 73.14  ? 213 SER A CB   1 
ATOM   3544 O OG   . SER B  1 213 ? 137.821 109.748 115.975 1.00 81.16  ? 213 SER A OG   1 
ATOM   3545 N N    . ALA B  1 214 ? 138.074 105.430 114.978 1.00 74.78  ? 214 ALA A N    1 
ATOM   3546 C CA   . ALA B  1 214 ? 138.482 104.159 114.392 1.00 71.57  ? 214 ALA A CA   1 
ATOM   3547 C C    . ALA B  1 214 ? 137.445 103.679 113.388 1.00 72.76  ? 214 ALA A C    1 
ATOM   3548 O O    . ALA B  1 214 ? 137.789 103.136 112.335 1.00 72.93  ? 214 ALA A O    1 
ATOM   3549 C CB   . ALA B  1 214 ? 138.699 103.114 115.486 1.00 78.04  ? 214 ALA A CB   1 
ATOM   3550 N N    . MET B  1 215 ? 136.166 103.871 113.704 1.00 82.69  ? 215 MET A N    1 
ATOM   3551 C CA   . MET B  1 215 ? 135.105 103.735 112.726 1.00 81.94  ? 215 MET A CA   1 
ATOM   3552 C C    . MET B  1 215 ? 134.948 105.051 111.962 1.00 90.87  ? 215 MET A C    1 
ATOM   3553 O O    . MET B  1 215 ? 135.625 106.046 112.236 1.00 98.67  ? 215 MET A O    1 
ATOM   3554 C CB   . MET B  1 215 ? 133.804 103.322 113.410 1.00 77.95  ? 215 MET A CB   1 
ATOM   3555 C CG   . MET B  1 215 ? 132.883 102.486 112.548 1.00 81.58  ? 215 MET A CG   1 
ATOM   3556 S SD   . MET B  1 215 ? 131.294 102.179 113.342 1.00 93.25  ? 215 MET A SD   1 
ATOM   3557 C CE   . MET B  1 215 ? 131.052 103.722 114.217 1.00 78.67  ? 215 MET A CE   1 
ATOM   3558 N N    . TYR B  1 216 ? 134.041 105.054 110.988 1.00 71.33  ? 216 TYR A N    1 
ATOM   3559 C CA   . TYR B  1 216 ? 133.817 106.191 110.101 1.00 68.46  ? 216 TYR A CA   1 
ATOM   3560 C C    . TYR B  1 216 ? 134.955 106.371 109.102 1.00 71.85  ? 216 TYR A C    1 
ATOM   3561 O O    . TYR B  1 216 ? 134.818 107.128 108.138 1.00 81.16  ? 216 TYR A O    1 
ATOM   3562 C CB   . TYR B  1 216 ? 133.682 107.502 110.882 1.00 65.75  ? 216 TYR A CB   1 
ATOM   3563 C CG   . TYR B  1 216 ? 132.553 107.600 111.876 1.00 62.30  ? 216 TYR A CG   1 
ATOM   3564 C CD1  . TYR B  1 216 ? 131.412 106.827 111.755 1.00 72.97  ? 216 TYR A CD1  1 
ATOM   3565 C CD2  . TYR B  1 216 ? 132.624 108.505 112.924 1.00 61.20  ? 216 TYR A CD2  1 
ATOM   3566 C CE1  . TYR B  1 216 ? 130.382 106.939 112.667 1.00 74.88  ? 216 TYR A CE1  1 
ATOM   3567 C CE2  . TYR B  1 216 ? 131.602 108.622 113.834 1.00 62.19  ? 216 TYR A CE2  1 
ATOM   3568 C CZ   . TYR B  1 216 ? 130.484 107.837 113.703 1.00 69.58  ? 216 TYR A CZ   1 
ATOM   3569 O OH   . TYR B  1 216 ? 129.463 107.960 114.616 1.00 73.52  ? 216 TYR A OH   1 
ATOM   3570 N N    . THR B  1 217 ? 136.075 105.687 109.314 1.00 75.33  ? 217 THR A N    1 
ATOM   3571 C CA   . THR B  1 217 ? 137.185 105.813 108.379 1.00 75.98  ? 217 THR A CA   1 
ATOM   3572 C C    . THR B  1 217 ? 137.038 104.855 107.206 1.00 82.99  ? 217 THR A C    1 
ATOM   3573 O O    . THR B  1 217 ? 137.169 105.267 106.047 1.00 88.07  ? 217 THR A O    1 
ATOM   3574 C CB   . THR B  1 217 ? 138.516 105.582 109.091 1.00 75.53  ? 217 THR A CB   1 
ATOM   3575 O OG1  . THR B  1 217 ? 138.667 106.543 110.140 1.00 77.14  ? 217 THR A OG1  1 
ATOM   3576 C CG2  . THR B  1 217 ? 139.664 105.731 108.113 1.00 76.46  ? 217 THR A CG2  1 
ATOM   3577 N N    . PRO B  1 218 ? 136.772 103.573 107.457 1.00 77.65  ? 218 PRO A N    1 
ATOM   3578 C CA   . PRO B  1 218 ? 136.576 102.635 106.344 1.00 79.11  ? 218 PRO A CA   1 
ATOM   3579 C C    . PRO B  1 218 ? 135.175 102.695 105.760 1.00 84.40  ? 218 PRO A C    1 
ATOM   3580 O O    . PRO B  1 218 ? 134.994 102.525 104.550 1.00 86.61  ? 218 PRO A O    1 
ATOM   3581 C CB   . PRO B  1 218 ? 136.857 101.268 106.985 1.00 81.10  ? 218 PRO A CB   1 
ATOM   3582 C CG   . PRO B  1 218 ? 137.458 101.577 108.344 1.00 79.61  ? 218 PRO A CG   1 
ATOM   3583 C CD   . PRO B  1 218 ? 136.843 102.870 108.742 1.00 76.73  ? 218 PRO A CD   1 
ATOM   3584 N N    . ILE B  1 219 ? 134.173 102.934 106.608 1.00 82.58  ? 219 ILE A N    1 
ATOM   3585 C CA   . ILE B  1 219 ? 132.792 102.888 106.142 1.00 81.96  ? 219 ILE A CA   1 
ATOM   3586 C C    . ILE B  1 219 ? 132.495 104.077 105.237 1.00 84.36  ? 219 ILE A C    1 
ATOM   3587 O O    . ILE B  1 219 ? 131.865 103.931 104.185 1.00 91.05  ? 219 ILE A O    1 
ATOM   3588 C CB   . ILE B  1 219 ? 131.828 102.827 107.337 1.00 78.44  ? 219 ILE A CB   1 
ATOM   3589 C CG1  . ILE B  1 219 ? 132.044 101.531 108.117 1.00 81.59  ? 219 ILE A CG1  1 
ATOM   3590 C CG2  . ILE B  1 219 ? 130.394 102.930 106.866 1.00 81.39  ? 219 ILE A CG2  1 
ATOM   3591 C CD1  . ILE B  1 219 ? 131.062 101.323 109.241 1.00 82.25  ? 219 ILE A CD1  1 
ATOM   3592 N N    . GLU B  1 220 ? 132.936 105.258 105.636 1.00 76.12  ? 220 GLU A N    1 
ATOM   3593 C CA   . GLU B  1 220 ? 132.859 106.459 104.820 1.00 74.89  ? 220 GLU A CA   1 
ATOM   3594 C C    . GLU B  1 220 ? 134.269 106.931 104.512 1.00 82.53  ? 220 GLU A C    1 
ATOM   3595 O O    . GLU B  1 220 ? 135.178 106.780 105.330 1.00 90.73  ? 220 GLU A O    1 
ATOM   3596 C CB   . GLU B  1 220 ? 132.071 107.558 105.534 1.00 72.36  ? 220 GLU A CB   1 
ATOM   3597 C CG   . GLU B  1 220 ? 130.624 107.189 105.784 1.00 79.79  ? 220 GLU A CG   1 
ATOM   3598 C CD   . GLU B  1 220 ? 129.989 108.030 106.863 1.00 79.99  ? 220 GLU A CD   1 
ATOM   3599 O OE1  . GLU B  1 220 ? 130.722 108.491 107.758 1.00 84.89  ? 220 GLU A OE1  1 
ATOM   3600 O OE2  . GLU B  1 220 ? 128.758 108.230 106.816 1.00 79.69  ? 220 GLU A OE2  1 
ATOM   3601 N N    . GLY B  1 221 ? 134.455 107.505 103.329 1.00 83.37  ? 221 GLY A N    1 
ATOM   3602 C CA   . GLY B  1 221 ? 135.806 107.841 102.929 1.00 80.83  ? 221 GLY A CA   1 
ATOM   3603 C C    . GLY B  1 221 ? 136.235 109.179 103.482 1.00 82.76  ? 221 GLY A C    1 
ATOM   3604 O O    . GLY B  1 221 ? 135.994 110.229 102.879 1.00 86.90  ? 221 GLY A O    1 
ATOM   3605 N N    . TRP B  1 222 ? 136.905 109.137 104.633 1.00 72.35  ? 222 TRP A N    1 
ATOM   3606 C CA   . TRP B  1 222 ? 137.367 110.323 105.336 1.00 73.82  ? 222 TRP A CA   1 
ATOM   3607 C C    . TRP B  1 222 ? 138.777 110.066 105.834 1.00 78.77  ? 222 TRP A C    1 
ATOM   3608 O O    . TRP B  1 222 ? 139.207 108.918 105.980 1.00 85.43  ? 222 TRP A O    1 
ATOM   3609 C CB   . TRP B  1 222 ? 136.465 110.680 106.529 1.00 66.14  ? 222 TRP A CB   1 
ATOM   3610 C CG   . TRP B  1 222 ? 135.107 111.209 106.182 1.00 66.35  ? 222 TRP A CG   1 
ATOM   3611 C CD1  . TRP B  1 222 ? 134.673 111.627 104.961 1.00 74.43  ? 222 TRP A CD1  1 
ATOM   3612 C CD2  . TRP B  1 222 ? 134.004 111.386 107.081 1.00 69.26  ? 222 TRP A CD2  1 
ATOM   3613 N NE1  . TRP B  1 222 ? 133.370 112.047 105.042 1.00 72.51  ? 222 TRP A NE1  1 
ATOM   3614 C CE2  . TRP B  1 222 ? 132.938 111.909 106.335 1.00 70.48  ? 222 TRP A CE2  1 
ATOM   3615 C CE3  . TRP B  1 222 ? 133.821 111.148 108.446 1.00 70.51  ? 222 TRP A CE3  1 
ATOM   3616 C CZ2  . TRP B  1 222 ? 131.702 112.202 106.903 1.00 72.46  ? 222 TRP A CZ2  1 
ATOM   3617 C CZ3  . TRP B  1 222 ? 132.596 111.440 109.008 1.00 64.44  ? 222 TRP A CZ3  1 
ATOM   3618 C CH2  . TRP B  1 222 ? 131.553 111.958 108.240 1.00 69.96  ? 222 TRP A CH2  1 
ATOM   3619 N N    . SER B  1 223 ? 139.503 111.147 106.093 1.00 75.50  ? 223 SER A N    1 
ATOM   3620 C CA   . SER B  1 223 ? 140.769 111.014 106.787 1.00 67.98  ? 223 SER A CA   1 
ATOM   3621 C C    . SER B  1 223 ? 140.523 110.833 108.280 1.00 73.52  ? 223 SER A C    1 
ATOM   3622 O O    . SER B  1 223 ? 139.441 111.116 108.796 1.00 84.04  ? 223 SER A O    1 
ATOM   3623 C CB   . SER B  1 223 ? 141.653 112.237 106.544 1.00 75.82  ? 223 SER A CB   1 
ATOM   3624 O OG   . SER B  1 223 ? 141.487 112.732 105.229 1.00 89.25  ? 223 SER A OG   1 
ATOM   3625 N N    . TYR B  1 224 ? 141.548 110.351 108.981 1.00 67.96  ? 224 TYR A N    1 
ATOM   3626 C CA   . TYR B  1 224 ? 141.433 110.193 110.426 1.00 71.77  ? 224 TYR A CA   1 
ATOM   3627 C C    . TYR B  1 224 ? 141.232 111.542 111.104 1.00 77.59  ? 224 TYR A C    1 
ATOM   3628 O O    . TYR B  1 224 ? 140.413 111.673 112.026 1.00 81.12  ? 224 TYR A O    1 
ATOM   3629 C CB   . TYR B  1 224 ? 142.672 109.484 110.967 1.00 71.85  ? 224 TYR A CB   1 
ATOM   3630 C CG   . TYR B  1 224 ? 142.470 108.812 112.303 1.00 75.74  ? 224 TYR A CG   1 
ATOM   3631 C CD1  . TYR B  1 224 ? 142.003 107.508 112.378 1.00 76.93  ? 224 TYR A CD1  1 
ATOM   3632 C CD2  . TYR B  1 224 ? 142.750 109.475 113.485 1.00 80.22  ? 224 TYR A CD2  1 
ATOM   3633 C CE1  . TYR B  1 224 ? 141.816 106.889 113.596 1.00 81.87  ? 224 TYR A CE1  1 
ATOM   3634 C CE2  . TYR B  1 224 ? 142.567 108.865 114.708 1.00 74.99  ? 224 TYR A CE2  1 
ATOM   3635 C CZ   . TYR B  1 224 ? 142.099 107.574 114.758 1.00 79.55  ? 224 TYR A CZ   1 
ATOM   3636 O OH   . TYR B  1 224 ? 141.920 106.963 115.974 1.00 80.43  ? 224 TYR A OH   1 
ATOM   3637 N N    . PHE B  1 225 ? 141.960 112.562 110.650 1.00 74.60  ? 225 PHE A N    1 
ATOM   3638 C CA   . PHE B  1 225 ? 141.805 113.891 111.228 1.00 74.42  ? 225 PHE A CA   1 
ATOM   3639 C C    . PHE B  1 225 ? 140.416 114.456 110.958 1.00 77.48  ? 225 PHE A C    1 
ATOM   3640 O O    . PHE B  1 225 ? 139.846 115.142 111.815 1.00 80.80  ? 225 PHE A O    1 
ATOM   3641 C CB   . PHE B  1 225 ? 142.885 114.829 110.685 1.00 76.55  ? 225 PHE A CB   1 
ATOM   3642 C CG   . PHE B  1 225 ? 142.825 116.216 111.254 1.00 80.43  ? 225 PHE A CG   1 
ATOM   3643 C CD1  . PHE B  1 225 ? 143.011 116.430 112.607 1.00 76.26  ? 225 PHE A CD1  1 
ATOM   3644 C CD2  . PHE B  1 225 ? 142.589 117.305 110.435 1.00 79.03  ? 225 PHE A CD2  1 
ATOM   3645 C CE1  . PHE B  1 225 ? 142.953 117.703 113.132 1.00 71.89  ? 225 PHE A CE1  1 
ATOM   3646 C CE2  . PHE B  1 225 ? 142.533 118.580 110.956 1.00 76.54  ? 225 PHE A CE2  1 
ATOM   3647 C CZ   . PHE B  1 225 ? 142.716 118.778 112.306 1.00 74.42  ? 225 PHE A CZ   1 
ATOM   3648 N N    . ASP B  1 226 ? 139.854 114.182 109.783 1.00 73.79  ? 226 ASP A N    1 
ATOM   3649 C CA   . ASP B  1 226 ? 138.482 114.602 109.517 1.00 71.55  ? 226 ASP A CA   1 
ATOM   3650 C C    . ASP B  1 226 ? 137.505 113.921 110.464 1.00 71.37  ? 226 ASP A C    1 
ATOM   3651 O O    . ASP B  1 226 ? 136.542 114.541 110.927 1.00 75.56  ? 226 ASP A O    1 
ATOM   3652 C CB   . ASP B  1 226 ? 138.108 114.311 108.065 1.00 74.57  ? 226 ASP A CB   1 
ATOM   3653 C CG   . ASP B  1 226 ? 138.678 115.329 107.103 1.00 76.93  ? 226 ASP A CG   1 
ATOM   3654 O OD1  . ASP B  1 226 ? 139.482 116.177 107.541 1.00 80.97  ? 226 ASP A OD1  1 
ATOM   3655 O OD2  . ASP B  1 226 ? 138.320 115.289 105.907 1.00 74.63  ? 226 ASP A OD2  1 
ATOM   3656 N N    . SER B  1 227 ? 137.734 112.641 110.765 1.00 65.73  ? 227 SER A N    1 
ATOM   3657 C CA   . SER B  1 227 ? 136.884 111.949 111.724 1.00 65.56  ? 227 SER A CA   1 
ATOM   3658 C C    . SER B  1 227 ? 136.978 112.586 113.103 1.00 72.37  ? 227 SER A C    1 
ATOM   3659 O O    . SER B  1 227 ? 135.959 112.776 113.779 1.00 76.14  ? 227 SER A O    1 
ATOM   3660 C CB   . SER B  1 227 ? 137.260 110.471 111.789 1.00 68.75  ? 227 SER A CB   1 
ATOM   3661 O OG   . SER B  1 227 ? 137.169 109.871 110.511 1.00 77.61  ? 227 SER A OG   1 
ATOM   3662 N N    . LEU B  1 228 ? 138.195 112.927 113.542 1.00 70.95  ? 228 LEU A N    1 
ATOM   3663 C CA   . LEU B  1 228 ? 138.346 113.581 114.840 1.00 61.49  ? 228 LEU A CA   1 
ATOM   3664 C C    . LEU B  1 228 ? 137.655 114.942 114.858 1.00 61.69  ? 228 LEU A C    1 
ATOM   3665 O O    . LEU B  1 228 ? 137.008 115.309 115.848 1.00 66.28  ? 228 LEU A O    1 
ATOM   3666 C CB   . LEU B  1 228 ? 139.825 113.723 115.187 1.00 59.57  ? 228 LEU A CB   1 
ATOM   3667 C CG   . LEU B  1 228 ? 140.582 112.425 115.465 1.00 64.16  ? 228 LEU A CG   1 
ATOM   3668 C CD1  . LEU B  1 228 ? 142.067 112.690 115.621 1.00 65.16  ? 228 LEU A CD1  1 
ATOM   3669 C CD2  . LEU B  1 228 ? 140.031 111.750 116.702 1.00 65.83  ? 228 LEU A CD2  1 
ATOM   3670 N N    . TYR B  1 229 ? 137.788 115.704 113.773 1.00 57.88  ? 229 TYR A N    1 
ATOM   3671 C CA   . TYR B  1 229 ? 137.137 117.006 113.688 1.00 59.68  ? 229 TYR A CA   1 
ATOM   3672 C C    . TYR B  1 229 ? 135.620 116.872 113.756 1.00 64.39  ? 229 TYR A C    1 
ATOM   3673 O O    . TYR B  1 229 ? 134.951 117.629 114.467 1.00 70.61  ? 229 TYR A O    1 
ATOM   3674 C CB   . TYR B  1 229 ? 137.571 117.705 112.400 1.00 60.04  ? 229 TYR A CB   1 
ATOM   3675 C CG   . TYR B  1 229 ? 136.885 119.021 112.116 1.00 61.69  ? 229 TYR A CG   1 
ATOM   3676 C CD1  . TYR B  1 229 ? 137.162 120.148 112.872 1.00 55.21  ? 229 TYR A CD1  1 
ATOM   3677 C CD2  . TYR B  1 229 ? 135.975 119.138 111.075 1.00 65.44  ? 229 TYR A CD2  1 
ATOM   3678 C CE1  . TYR B  1 229 ? 136.544 121.352 112.609 1.00 59.37  ? 229 TYR A CE1  1 
ATOM   3679 C CE2  . TYR B  1 229 ? 135.353 120.339 110.803 1.00 62.11  ? 229 TYR A CE2  1 
ATOM   3680 C CZ   . TYR B  1 229 ? 135.640 121.440 111.572 1.00 65.15  ? 229 TYR A CZ   1 
ATOM   3681 O OH   . TYR B  1 229 ? 135.021 122.637 111.305 1.00 69.23  ? 229 TYR A OH   1 
ATOM   3682 N N    . PHE B  1 230 ? 135.063 115.897 113.032 1.00 60.78  ? 230 PHE A N    1 
ATOM   3683 C CA   . PHE B  1 230 ? 133.624 115.669 113.096 1.00 56.63  ? 230 PHE A CA   1 
ATOM   3684 C C    . PHE B  1 230 ? 133.196 115.263 114.498 1.00 61.20  ? 230 PHE A C    1 
ATOM   3685 O O    . PHE B  1 230 ? 132.159 115.718 114.992 1.00 67.35  ? 230 PHE A O    1 
ATOM   3686 C CB   . PHE B  1 230 ? 133.210 114.601 112.088 1.00 58.63  ? 230 PHE A CB   1 
ATOM   3687 C CG   . PHE B  1 230 ? 131.839 114.040 112.337 1.00 60.88  ? 230 PHE A CG   1 
ATOM   3688 C CD1  . PHE B  1 230 ? 130.710 114.779 112.043 1.00 67.80  ? 230 PHE A CD1  1 
ATOM   3689 C CD2  . PHE B  1 230 ? 131.683 112.776 112.873 1.00 59.78  ? 230 PHE A CD2  1 
ATOM   3690 C CE1  . PHE B  1 230 ? 129.452 114.268 112.280 1.00 61.00  ? 230 PHE A CE1  1 
ATOM   3691 C CE2  . PHE B  1 230 ? 130.426 112.260 113.109 1.00 64.59  ? 230 PHE A CE2  1 
ATOM   3692 C CZ   . PHE B  1 230 ? 129.312 113.007 112.809 1.00 61.34  ? 230 PHE A CZ   1 
ATOM   3693 N N    . CYS B  1 231 ? 133.975 114.399 115.150 1.00 64.57  ? 231 CYS A N    1 
ATOM   3694 C CA   . CYS B  1 231 ? 133.619 113.970 116.498 1.00 54.03  ? 231 CYS A CA   1 
ATOM   3695 C C    . CYS B  1 231 ? 133.594 115.151 117.458 1.00 55.36  ? 231 CYS A C    1 
ATOM   3696 O O    . CYS B  1 231 ? 132.670 115.282 118.268 1.00 67.26  ? 231 CYS A O    1 
ATOM   3697 C CB   . CYS B  1 231 ? 134.596 112.899 116.986 1.00 55.56  ? 231 CYS A CB   1 
ATOM   3698 S SG   . CYS B  1 231 ? 134.383 111.289 116.205 1.00 80.68  ? 231 CYS A SG   1 
ATOM   3699 N N    . PHE B  1 232 ? 134.592 116.034 117.376 1.00 52.43  ? 232 PHE A N    1 
ATOM   3700 C CA   . PHE B  1 232 ? 134.588 117.193 118.266 1.00 47.47  ? 232 PHE A CA   1 
ATOM   3701 C C    . PHE B  1 232 ? 133.430 118.131 117.957 1.00 53.20  ? 232 PHE A C    1 
ATOM   3702 O O    . PHE B  1 232 ? 132.797 118.661 118.877 1.00 56.66  ? 232 PHE A O    1 
ATOM   3703 C CB   . PHE B  1 232 ? 135.906 117.955 118.186 1.00 48.46  ? 232 PHE A CB   1 
ATOM   3704 C CG   . PHE B  1 232 ? 135.905 119.220 118.993 1.00 57.34  ? 232 PHE A CG   1 
ATOM   3705 C CD1  . PHE B  1 232 ? 135.964 119.177 120.374 1.00 58.17  ? 232 PHE A CD1  1 
ATOM   3706 C CD2  . PHE B  1 232 ? 135.819 120.455 118.372 1.00 56.82  ? 232 PHE A CD2  1 
ATOM   3707 C CE1  . PHE B  1 232 ? 135.952 120.337 121.122 1.00 53.76  ? 232 PHE A CE1  1 
ATOM   3708 C CE2  . PHE B  1 232 ? 135.807 121.619 119.115 1.00 53.98  ? 232 PHE A CE2  1 
ATOM   3709 C CZ   . PHE B  1 232 ? 135.872 121.559 120.490 1.00 48.80  ? 232 PHE A CZ   1 
ATOM   3710 N N    . VAL B  1 233 ? 133.140 118.360 116.676 1.00 58.44  ? 233 VAL A N    1 
ATOM   3711 C CA   . VAL B  1 233 ? 132.067 119.290 116.331 1.00 49.08  ? 233 VAL A CA   1 
ATOM   3712 C C    . VAL B  1 233 ? 130.719 118.745 116.784 1.00 56.22  ? 233 VAL A C    1 
ATOM   3713 O O    . VAL B  1 233 ? 129.859 119.500 117.254 1.00 59.03  ? 233 VAL A O    1 
ATOM   3714 C CB   . VAL B  1 233 ? 132.082 119.593 114.823 1.00 49.51  ? 233 VAL A CB   1 
ATOM   3715 C CG1  . VAL B  1 233 ? 130.854 120.391 114.438 1.00 51.03  ? 233 VAL A CG1  1 
ATOM   3716 C CG2  . VAL B  1 233 ? 133.341 120.349 114.451 1.00 54.25  ? 233 VAL A CG2  1 
ATOM   3717 N N    . ALA B  1 234 ? 130.501 117.437 116.639 1.00 57.73  ? 234 ALA A N    1 
ATOM   3718 C CA   . ALA B  1 234 ? 129.218 116.855 117.026 1.00 51.17  ? 234 ALA A CA   1 
ATOM   3719 C C    . ALA B  1 234 ? 129.079 116.749 118.540 1.00 51.21  ? 234 ALA A C    1 
ATOM   3720 O O    . ALA B  1 234 ? 128.011 117.037 119.088 1.00 57.81  ? 234 ALA A O    1 
ATOM   3721 C CB   . ALA B  1 234 ? 129.049 115.484 116.377 1.00 49.51  ? 234 ALA A CB   1 
ATOM   3722 N N    . PHE B  1 235 ? 130.145 116.342 119.238 1.00 56.61  ? 235 PHE A N    1 
ATOM   3723 C CA   . PHE B  1 235 ? 130.037 116.106 120.675 1.00 49.87  ? 235 PHE A CA   1 
ATOM   3724 C C    . PHE B  1 235 ? 129.803 117.395 121.449 1.00 51.89  ? 235 PHE A C    1 
ATOM   3725 O O    . PHE B  1 235 ? 129.096 117.385 122.462 1.00 51.50  ? 235 PHE A O    1 
ATOM   3726 C CB   . PHE B  1 235 ? 131.291 115.404 121.190 1.00 48.68  ? 235 PHE A CB   1 
ATOM   3727 C CG   . PHE B  1 235 ? 131.425 113.981 120.729 1.00 56.69  ? 235 PHE A CG   1 
ATOM   3728 C CD1  . PHE B  1 235 ? 130.350 113.313 120.176 1.00 57.68  ? 235 PHE A CD1  1 
ATOM   3729 C CD2  . PHE B  1 235 ? 132.628 113.311 120.857 1.00 59.44  ? 235 PHE A CD2  1 
ATOM   3730 C CE1  . PHE B  1 235 ? 130.472 112.006 119.754 1.00 56.79  ? 235 PHE A CE1  1 
ATOM   3731 C CE2  . PHE B  1 235 ? 132.757 112.004 120.437 1.00 55.87  ? 235 PHE A CE2  1 
ATOM   3732 C CZ   . PHE B  1 235 ? 131.678 111.350 119.885 1.00 57.01  ? 235 PHE A CZ   1 
ATOM   3733 N N    . SER B  1 236 ? 130.380 118.506 121.003 1.00 53.99  ? 236 SER A N    1 
ATOM   3734 C CA   . SER B  1 236 ? 130.220 119.777 121.695 1.00 51.05  ? 236 SER A CA   1 
ATOM   3735 C C    . SER B  1 236 ? 128.879 120.442 121.410 1.00 60.46  ? 236 SER A C    1 
ATOM   3736 O O    . SER B  1 236 ? 128.650 121.560 121.880 1.00 62.88  ? 236 SER A O    1 
ATOM   3737 C CB   . SER B  1 236 ? 131.355 120.730 121.316 1.00 52.43  ? 236 SER A CB   1 
ATOM   3738 O OG   . SER B  1 236 ? 131.318 121.032 119.935 1.00 54.17  ? 236 SER A OG   1 
ATOM   3739 N N    . THR B  1 237 ? 127.994 119.777 120.669 1.00 65.09  ? 237 THR A N    1 
ATOM   3740 C CA   . THR B  1 237 ? 126.685 120.320 120.313 1.00 56.76  ? 237 THR A CA   1 
ATOM   3741 C C    . THR B  1 237 ? 126.799 121.621 119.524 1.00 60.24  ? 237 THR A C    1 
ATOM   3742 O O    . THR B  1 237 ? 125.920 122.481 119.609 1.00 71.25  ? 237 THR A O    1 
ATOM   3743 C CB   . THR B  1 237 ? 125.810 120.529 121.550 1.00 56.96  ? 237 THR A CB   1 
ATOM   3744 O OG1  . THR B  1 237 ? 126.384 121.548 122.374 1.00 63.59  ? 237 THR A OG1  1 
ATOM   3745 C CG2  . THR B  1 237 ? 125.691 119.244 122.345 1.00 53.92  ? 237 THR A CG2  1 
ATOM   3746 N N    . ILE B  1 238 ? 127.869 121.775 118.750 1.00 42.57  ? 238 ILE A N    1 
ATOM   3747 C CA   . ILE B  1 238 ? 127.955 122.898 117.821 1.00 48.30  ? 238 ILE A CA   1 
ATOM   3748 C C    . ILE B  1 238 ? 127.218 122.569 116.529 1.00 57.44  ? 238 ILE A C    1 
ATOM   3749 O O    . ILE B  1 238 ? 126.268 123.259 116.145 1.00 65.80  ? 238 ILE A O    1 
ATOM   3750 C CB   . ILE B  1 238 ? 129.425 123.274 117.556 1.00 43.64  ? 238 ILE A CB   1 
ATOM   3751 C CG1  . ILE B  1 238 ? 130.062 123.851 118.817 1.00 46.79  ? 238 ILE A CG1  1 
ATOM   3752 C CG2  . ILE B  1 238 ? 129.522 124.269 116.419 1.00 41.25  ? 238 ILE A CG2  1 
ATOM   3753 C CD1  . ILE B  1 238 ? 131.490 124.298 118.623 1.00 50.50  ? 238 ILE A CD1  1 
ATOM   3754 N N    . GLY B  1 239 ? 127.640 121.508 115.851 1.00 51.41  ? 239 GLY A N    1 
ATOM   3755 C CA   . GLY B  1 239 ? 126.923 121.007 114.697 1.00 44.49  ? 239 GLY A CA   1 
ATOM   3756 C C    . GLY B  1 239 ? 126.919 121.932 113.500 1.00 52.87  ? 239 GLY A C    1 
ATOM   3757 O O    . GLY B  1 239 ? 125.870 122.465 113.130 1.00 65.15  ? 239 GLY A O    1 
ATOM   3758 N N    . PHE B  1 240 ? 128.084 122.130 112.882 1.00 56.03  ? 240 PHE A N    1 
ATOM   3759 C CA   . PHE B  1 240 ? 128.141 122.967 111.689 1.00 54.78  ? 240 PHE A CA   1 
ATOM   3760 C C    . PHE B  1 240 ? 127.306 122.377 110.561 1.00 57.16  ? 240 PHE A C    1 
ATOM   3761 O O    . PHE B  1 240 ? 126.558 123.098 109.893 1.00 62.97  ? 240 PHE A O    1 
ATOM   3762 C CB   . PHE B  1 240 ? 129.590 123.143 111.241 1.00 51.52  ? 240 PHE A CB   1 
ATOM   3763 C CG   . PHE B  1 240 ? 130.390 124.065 112.114 1.00 53.93  ? 240 PHE A CG   1 
ATOM   3764 C CD1  . PHE B  1 240 ? 129.805 125.182 112.676 1.00 54.97  ? 240 PHE A CD1  1 
ATOM   3765 C CD2  . PHE B  1 240 ? 131.724 123.814 112.369 1.00 54.89  ? 240 PHE A CD2  1 
ATOM   3766 C CE1  . PHE B  1 240 ? 130.538 126.032 113.476 1.00 57.36  ? 240 PHE A CE1  1 
ATOM   3767 C CE2  . PHE B  1 240 ? 132.460 124.660 113.170 1.00 53.32  ? 240 PHE A CE2  1 
ATOM   3768 C CZ   . PHE B  1 240 ? 131.866 125.771 113.722 1.00 52.78  ? 240 PHE A CZ   1 
ATOM   3769 N N    . GLY B  1 241 ? 127.408 121.071 110.344 1.00 62.60  ? 241 GLY A N    1 
ATOM   3770 C CA   . GLY B  1 241 ? 126.663 120.404 109.299 1.00 60.96  ? 241 GLY A CA   1 
ATOM   3771 C C    . GLY B  1 241 ? 127.436 120.131 108.029 1.00 63.62  ? 241 GLY A C    1 
ATOM   3772 O O    . GLY B  1 241 ? 126.871 119.551 107.098 1.00 66.97  ? 241 GLY A O    1 
ATOM   3773 N N    . ASP B  1 242 ? 128.707 120.530 107.958 1.00 76.13  ? 242 ASP A N    1 
ATOM   3774 C CA   . ASP B  1 242 ? 129.499 120.254 106.768 1.00 74.53  ? 242 ASP A CA   1 
ATOM   3775 C C    . ASP B  1 242 ? 129.835 118.772 106.646 1.00 77.43  ? 242 ASP A C    1 
ATOM   3776 O O    . ASP B  1 242 ? 130.016 118.270 105.530 1.00 80.16  ? 242 ASP A O    1 
ATOM   3777 C CB   . ASP B  1 242 ? 130.779 121.093 106.779 1.00 75.31  ? 242 ASP A CB   1 
ATOM   3778 C CG   . ASP B  1 242 ? 131.584 120.905 108.047 1.00 84.43  ? 242 ASP A CG   1 
ATOM   3779 O OD1  . ASP B  1 242 ? 131.022 120.407 109.044 1.00 88.14  ? 242 ASP A OD1  1 
ATOM   3780 O OD2  . ASP B  1 242 ? 132.779 121.265 108.051 1.00 85.73  ? 242 ASP A OD2  1 
ATOM   3781 N N    . LEU B  1 243 ? 129.927 118.064 107.768 1.00 73.97  ? 243 LEU A N    1 
ATOM   3782 C CA   . LEU B  1 243 ? 130.133 116.620 107.781 1.00 69.66  ? 243 LEU A CA   1 
ATOM   3783 C C    . LEU B  1 243 ? 129.042 115.976 108.621 1.00 70.71  ? 243 LEU A C    1 
ATOM   3784 O O    . LEU B  1 243 ? 128.968 116.219 109.830 1.00 79.93  ? 243 LEU A O    1 
ATOM   3785 C CB   . LEU B  1 243 ? 131.515 116.260 108.334 1.00 69.58  ? 243 LEU A CB   1 
ATOM   3786 C CG   . LEU B  1 243 ? 132.735 116.713 107.536 1.00 69.47  ? 243 LEU A CG   1 
ATOM   3787 C CD1  . LEU B  1 243 ? 134.014 116.335 108.263 1.00 64.49  ? 243 LEU A CD1  1 
ATOM   3788 C CD2  . LEU B  1 243 ? 132.712 116.108 106.148 1.00 69.87  ? 243 LEU A CD2  1 
ATOM   3789 N N    . VAL B  1 244 ? 128.202 115.165 107.986 1.00 62.19  ? 244 VAL A N    1 
ATOM   3790 C CA   . VAL B  1 244 ? 127.154 114.422 108.672 1.00 63.70  ? 244 VAL A CA   1 
ATOM   3791 C C    . VAL B  1 244 ? 127.309 112.950 108.326 1.00 68.71  ? 244 VAL A C    1 
ATOM   3792 O O    . VAL B  1 244 ? 127.551 112.597 107.167 1.00 69.30  ? 244 VAL A O    1 
ATOM   3793 C CB   . VAL B  1 244 ? 125.744 114.924 108.295 1.00 62.01  ? 244 VAL A CB   1 
ATOM   3794 C CG1  . VAL B  1 244 ? 124.697 114.216 109.126 1.00 60.51  ? 244 VAL A CG1  1 
ATOM   3795 C CG2  . VAL B  1 244 ? 125.651 116.423 108.490 1.00 66.58  ? 244 VAL A CG2  1 
ATOM   3796 N N    . SER B  1 245 ? 127.174 112.094 109.331 1.00 71.17  ? 245 SER A N    1 
ATOM   3797 C CA   . SER B  1 245 ? 127.430 110.670 109.189 1.00 67.08  ? 245 SER A CA   1 
ATOM   3798 C C    . SER B  1 245 ? 126.148 109.898 108.901 1.00 74.92  ? 245 SER A C    1 
ATOM   3799 O O    . SER B  1 245 ? 125.039 110.333 109.216 1.00 78.08  ? 245 SER A O    1 
ATOM   3800 C CB   . SER B  1 245 ? 128.090 110.120 110.456 1.00 66.23  ? 245 SER A CB   1 
ATOM   3801 O OG   . SER B  1 245 ? 128.330 108.731 110.338 1.00 69.72  ? 245 SER A OG   1 
ATOM   3802 N N    . SER B  1 246 ? 126.327 108.724 108.298 1.00 74.06  ? 246 SER A N    1 
ATOM   3803 C CA   . SER B  1 246 ? 125.257 107.744 108.115 1.00 64.36  ? 246 SER A CA   1 
ATOM   3804 C C    . SER B  1 246 ? 124.139 108.268 107.211 1.00 66.83  ? 246 SER A C    1 
ATOM   3805 O O    . SER B  1 246 ? 122.973 108.332 107.597 1.00 76.59  ? 246 SER A O    1 
ATOM   3806 C CB   . SER B  1 246 ? 124.695 107.303 109.469 1.00 70.36  ? 246 SER A CB   1 
ATOM   3807 O OG   . SER B  1 246 ? 123.575 106.458 109.297 1.00 71.75  ? 246 SER A OG   1 
ATOM   3808 N N    . GLN B  1 247 ? 124.515 108.647 105.987 1.00 70.90  ? 247 GLN A N    1 
ATOM   3809 C CA   . GLN B  1 247 ? 123.520 108.885 104.941 1.00 73.93  ? 247 GLN A CA   1 
ATOM   3810 C C    . GLN B  1 247 ? 124.167 108.629 103.585 1.00 72.49  ? 247 GLN A C    1 
ATOM   3811 O O    . GLN B  1 247 ? 124.801 109.523 103.018 1.00 80.71  ? 247 GLN A O    1 
ATOM   3812 C CB   . GLN B  1 247 ? 122.943 110.288 105.038 1.00 67.71  ? 247 GLN A CB   1 
ATOM   3813 C CG   . GLN B  1 247 ? 123.864 111.306 105.661 1.00 67.64  ? 247 GLN A CG   1 
ATOM   3814 C CD   . GLN B  1 247 ? 123.156 112.613 105.927 1.00 79.42  ? 247 GLN A CD   1 
ATOM   3815 O OE1  . GLN B  1 247 ? 122.212 112.670 106.714 1.00 80.39  ? 247 GLN A OE1  1 
ATOM   3816 N NE2  . GLN B  1 247 ? 123.604 113.678 105.272 1.00 80.59  ? 247 GLN A NE2  1 
ATOM   3817 N N    . ASN B  1 248 ? 123.994 107.409 103.068 1.00 71.93  ? 248 ASN A N    1 
ATOM   3818 C CA   . ASN B  1 248 ? 124.454 107.073 101.726 1.00 76.21  ? 248 ASN A CA   1 
ATOM   3819 C C    . ASN B  1 248 ? 123.474 106.169 100.993 1.00 82.66  ? 248 ASN A C    1 
ATOM   3820 O O    . ASN B  1 248 ? 123.796 105.689 99.898  1.00 86.63  ? 248 ASN A O    1 
ATOM   3821 C CB   . ASN B  1 248 ? 125.835 106.411 101.769 1.00 76.40  ? 248 ASN A CB   1 
ATOM   3822 C CG   . ASN B  1 248 ? 126.965 107.411 101.657 1.00 76.25  ? 248 ASN A CG   1 
ATOM   3823 O OD1  . ASN B  1 248 ? 126.764 108.546 101.227 1.00 77.92  ? 248 ASN A OD1  1 
ATOM   3824 N ND2  . ASN B  1 248 ? 128.164 106.993 102.037 1.00 78.07  ? 248 ASN A ND2  1 
ATOM   3825 N N    . ALA B  1 249 ? 122.297 105.912 101.560 1.00 86.39  ? 249 ALA A N    1 
ATOM   3826 C CA   . ALA B  1 249 ? 121.274 105.073 100.945 1.00 88.22  ? 249 ALA A CA   1 
ATOM   3827 C C    . ALA B  1 249 ? 121.673 103.603 100.895 1.00 87.55  ? 249 ALA A C    1 
ATOM   3828 O O    . ALA B  1 249 ? 120.864 102.758 100.506 1.00 92.01  ? 249 ALA A O    1 
ATOM   3829 C CB   . ALA B  1 249 ? 120.963 105.574 99.533  1.00 83.62  ? 249 ALA A CB   1 
ATOM   3830 N N    . HIS B  1 250 ? 122.906 103.283 101.286 1.00 87.91  ? 250 HIS A N    1 
ATOM   3831 C CA   . HIS B  1 250 ? 123.317 101.885 101.387 1.00 87.96  ? 250 HIS A CA   1 
ATOM   3832 C C    . HIS B  1 250 ? 124.605 101.814 102.189 1.00 90.45  ? 250 HIS A C    1 
ATOM   3833 O O    . HIS B  1 250 ? 125.608 102.419 101.798 1.00 91.60  ? 250 HIS A O    1 
ATOM   3834 C CB   . HIS B  1 250 ? 123.506 101.265 100.008 1.00 89.95  ? 250 HIS A CB   1 
ATOM   3835 C CG   . HIS B  1 250 ? 123.342 99.778  99.989  1.00 93.86  ? 250 HIS A CG   1 
ATOM   3836 N ND1  . HIS B  1 250 ? 122.277 99.140  100.589 1.00 93.94  ? 250 HIS A ND1  1 
ATOM   3837 C CD2  . HIS B  1 250 ? 124.112 98.802  99.453  1.00 93.60  ? 250 HIS A CD2  1 
ATOM   3838 C CE1  . HIS B  1 250 ? 122.396 97.835  100.417 1.00 94.64  ? 250 HIS A CE1  1 
ATOM   3839 N NE2  . HIS B  1 250 ? 123.498 97.604  99.730  1.00 95.04  ? 250 HIS A NE2  1 
ATOM   3840 N N    . TYR B  1 251 ? 124.585 101.077 103.296 1.00 80.36  ? 251 TYR A N    1 
ATOM   3841 C CA   . TYR B  1 251 ? 125.727 100.971 104.201 1.00 77.98  ? 251 TYR A CA   1 
ATOM   3842 C C    . TYR B  1 251 ? 125.964 99.524  104.594 1.00 81.59  ? 251 TYR A C    1 
ATOM   3843 O O    . TYR B  1 251 ? 126.114 99.192  105.771 1.00 90.81  ? 251 TYR A O    1 
ATOM   3844 C CB   . TYR B  1 251 ? 125.524 101.827 105.446 1.00 79.22  ? 251 TYR A CB   1 
ATOM   3845 C CG   . TYR B  1 251 ? 126.051 103.233 105.323 1.00 77.28  ? 251 TYR A CG   1 
ATOM   3846 C CD1  . TYR B  1 251 ? 127.412 103.477 105.248 1.00 76.08  ? 251 TYR A CD1  1 
ATOM   3847 C CD2  . TYR B  1 251 ? 125.188 104.318 105.294 1.00 78.10  ? 251 TYR A CD2  1 
ATOM   3848 C CE1  . TYR B  1 251 ? 127.899 104.760 105.139 1.00 76.83  ? 251 TYR A CE1  1 
ATOM   3849 C CE2  . TYR B  1 251 ? 125.668 105.602 105.185 1.00 78.14  ? 251 TYR A CE2  1 
ATOM   3850 C CZ   . TYR B  1 251 ? 127.023 105.819 105.111 1.00 77.64  ? 251 TYR A CZ   1 
ATOM   3851 O OH   . TYR B  1 251 ? 127.507 107.099 105.002 1.00 85.27  ? 251 TYR A OH   1 
ATOM   3852 N N    . GLU B  1 252 ? 126.031 98.636  103.602 1.00 92.49  ? 252 GLU A N    1 
ATOM   3853 C CA   . GLU B  1 252 ? 126.193 97.214  103.880 1.00 95.03  ? 252 GLU A CA   1 
ATOM   3854 C C    . GLU B  1 252 ? 125.212 96.775  104.956 1.00 98.89  ? 252 GLU A C    1 
ATOM   3855 O O    . GLU B  1 252 ? 123.995 96.843  104.755 1.00 102.88 ? 252 GLU A O    1 
ATOM   3856 C CB   . GLU B  1 252 ? 127.628 96.907  104.308 1.00 91.27  ? 252 GLU A CB   1 
ATOM   3857 C CG   . GLU B  1 252 ? 128.127 95.551  103.854 1.00 93.90  ? 252 GLU A CG   1 
ATOM   3858 C CD   . GLU B  1 252 ? 128.264 95.461  102.349 1.00 101.11 ? 252 GLU A CD   1 
ATOM   3859 O OE1  . GLU B  1 252 ? 127.238 95.263  101.666 1.00 102.85 ? 252 GLU A OE1  1 
ATOM   3860 O OE2  . GLU B  1 252 ? 129.402 95.585  101.849 1.00 103.17 ? 252 GLU A OE2  1 
ATOM   3861 N N    . SER B  1 253 ? 125.726 96.309  106.098 1.00 86.87  ? 253 SER A N    1 
ATOM   3862 C CA   . SER B  1 253 ? 124.857 95.750  107.130 1.00 85.30  ? 253 SER A CA   1 
ATOM   3863 C C    . SER B  1 253 ? 123.723 96.709  107.475 1.00 87.63  ? 253 SER A C    1 
ATOM   3864 O O    . SER B  1 253 ? 122.548 96.332  107.472 1.00 90.67  ? 253 SER A O    1 
ATOM   3865 C CB   . SER B  1 253 ? 125.677 95.413  108.375 1.00 84.22  ? 253 SER A CB   1 
ATOM   3866 O OG   . SER B  1 253 ? 124.846 94.906  109.404 1.00 85.62  ? 253 SER A OG   1 
ATOM   3867 N N    . GLN B  1 254 ? 124.068 97.959  107.776 1.00 79.04  ? 254 GLN A N    1 
ATOM   3868 C CA   . GLN B  1 254 ? 123.101 99.039  107.943 1.00 75.92  ? 254 GLN A CA   1 
ATOM   3869 C C    . GLN B  1 254 ? 122.221 98.865  109.173 1.00 77.11  ? 254 GLN A C    1 
ATOM   3870 O O    . GLN B  1 254 ? 121.430 99.753  109.496 1.00 80.61  ? 254 GLN A O    1 
ATOM   3871 C CB   . GLN B  1 254 ? 122.214 99.161  106.702 1.00 76.75  ? 254 GLN A CB   1 
ATOM   3872 C CG   . GLN B  1 254 ? 121.608 100.540 106.525 1.00 76.36  ? 254 GLN A CG   1 
ATOM   3873 C CD   . GLN B  1 254 ? 120.642 100.610 105.362 1.00 82.57  ? 254 GLN A CD   1 
ATOM   3874 O OE1  . GLN B  1 254 ? 120.358 99.603  104.716 1.00 86.38  ? 254 GLN A OE1  1 
ATOM   3875 N NE2  . GLN B  1 254 ? 120.132 101.803 105.089 1.00 82.59  ? 254 GLN A NE2  1 
ATOM   3876 N N    . GLY B  1 255 ? 122.342 97.740  109.864 1.00 72.48  ? 255 GLY A N    1 
ATOM   3877 C CA   . GLY B  1 255 ? 121.541 97.533  111.051 1.00 72.11  ? 255 GLY A CA   1 
ATOM   3878 C C    . GLY B  1 255 ? 122.265 97.947  112.310 1.00 71.16  ? 255 GLY A C    1 
ATOM   3879 O O    . GLY B  1 255 ? 121.762 98.755  113.095 1.00 77.11  ? 255 GLY A O    1 
ATOM   3880 N N    . LEU B  1 256 ? 123.461 97.399  112.508 1.00 69.83  ? 256 LEU A N    1 
ATOM   3881 C CA   . LEU B  1 256 ? 124.263 97.734  113.676 1.00 74.08  ? 256 LEU A CA   1 
ATOM   3882 C C    . LEU B  1 256 ? 124.950 99.087  113.545 1.00 79.89  ? 256 LEU A C    1 
ATOM   3883 O O    . LEU B  1 256 ? 125.318 99.683  114.562 1.00 84.26  ? 256 LEU A O    1 
ATOM   3884 C CB   . LEU B  1 256 ? 125.310 96.648  113.911 1.00 73.79  ? 256 LEU A CB   1 
ATOM   3885 C CG   . LEU B  1 256 ? 124.781 95.217  114.015 1.00 71.41  ? 256 LEU A CG   1 
ATOM   3886 C CD1  . LEU B  1 256 ? 124.701 94.582  112.638 1.00 71.95  ? 256 LEU A CD1  1 
ATOM   3887 C CD2  . LEU B  1 256 ? 125.653 94.387  114.935 1.00 76.81  ? 256 LEU A CD2  1 
ATOM   3888 N N    . TYR B  1 257 ? 125.125 99.582  112.320 1.00 70.69  ? 257 TYR A N    1 
ATOM   3889 C CA   . TYR B  1 257 ? 125.821 100.849 112.122 1.00 69.21  ? 257 TYR A CA   1 
ATOM   3890 C C    . TYR B  1 257 ? 125.060 102.002 112.768 1.00 75.47  ? 257 TYR A C    1 
ATOM   3891 O O    . TYR B  1 257 ? 125.659 102.851 113.443 1.00 80.31  ? 257 TYR A O    1 
ATOM   3892 C CB   . TYR B  1 257 ? 126.030 101.093 110.627 1.00 65.33  ? 257 TYR A CB   1 
ATOM   3893 C CG   . TYR B  1 257 ? 126.830 102.324 110.288 1.00 67.81  ? 257 TYR A CG   1 
ATOM   3894 C CD1  . TYR B  1 257 ? 128.151 102.449 110.689 1.00 72.20  ? 257 TYR A CD1  1 
ATOM   3895 C CD2  . TYR B  1 257 ? 126.273 103.355 109.551 1.00 71.65  ? 257 TYR A CD2  1 
ATOM   3896 C CE1  . TYR B  1 257 ? 128.888 103.571 110.380 1.00 69.35  ? 257 TYR A CE1  1 
ATOM   3897 C CE2  . TYR B  1 257 ? 127.006 104.480 109.234 1.00 71.91  ? 257 TYR A CE2  1 
ATOM   3898 C CZ   . TYR B  1 257 ? 128.309 104.581 109.653 1.00 69.57  ? 257 TYR A CZ   1 
ATOM   3899 O OH   . TYR B  1 257 ? 129.039 105.701 109.336 1.00 74.22  ? 257 TYR A OH   1 
ATOM   3900 N N    . ARG B  1 258 ? 123.739 102.040 112.594 1.00 64.52  ? 258 ARG A N    1 
ATOM   3901 C CA   . ARG B  1 258 ? 122.944 103.110 113.184 1.00 65.84  ? 258 ARG A CA   1 
ATOM   3902 C C    . ARG B  1 258 ? 122.942 103.027 114.707 1.00 76.11  ? 258 ARG A C    1 
ATOM   3903 O O    . ARG B  1 258 ? 123.033 104.053 115.395 1.00 84.49  ? 258 ARG A O    1 
ATOM   3904 C CB   . ARG B  1 258 ? 121.523 103.059 112.630 1.00 66.24  ? 258 ARG A CB   1 
ATOM   3905 C CG   . ARG B  1 258 ? 121.457 103.271 111.127 1.00 70.74  ? 258 ARG A CG   1 
ATOM   3906 C CD   . ARG B  1 258 ? 120.049 103.105 110.590 1.00 76.20  ? 258 ARG A CD   1 
ATOM   3907 N NE   . ARG B  1 258 ? 119.962 103.470 109.182 1.00 75.10  ? 258 ARG A NE   1 
ATOM   3908 C CZ   . ARG B  1 258 ? 118.878 103.319 108.434 1.00 71.57  ? 258 ARG A CZ   1 
ATOM   3909 N NH1  . ARG B  1 258 ? 117.767 102.797 108.924 1.00 72.29  ? 258 ARG A NH1  1 
ATOM   3910 N NH2  . ARG B  1 258 ? 118.911 103.698 107.161 1.00 69.26  ? 258 ARG A NH2  1 
ATOM   3911 N N    . PHE B  1 259 ? 122.839 101.814 115.251 1.00 65.54  ? 259 PHE A N    1 
ATOM   3912 C CA   . PHE B  1 259 ? 122.893 101.640 116.699 1.00 65.06  ? 259 PHE A CA   1 
ATOM   3913 C C    . PHE B  1 259 ? 124.225 102.122 117.260 1.00 67.61  ? 259 PHE A C    1 
ATOM   3914 O O    . PHE B  1 259 ? 124.271 102.823 118.281 1.00 71.11  ? 259 PHE A O    1 
ATOM   3915 C CB   . PHE B  1 259 ? 122.644 100.169 117.043 1.00 60.35  ? 259 PHE A CB   1 
ATOM   3916 C CG   . PHE B  1 259 ? 122.787 99.846  118.499 1.00 61.89  ? 259 PHE A CG   1 
ATOM   3917 C CD1  . PHE B  1 259 ? 121.865 100.311 119.417 1.00 66.27  ? 259 PHE A CD1  1 
ATOM   3918 C CD2  . PHE B  1 259 ? 123.824 99.055  118.945 1.00 62.85  ? 259 PHE A CD2  1 
ATOM   3919 C CE1  . PHE B  1 259 ? 121.989 100.005 120.754 1.00 65.64  ? 259 PHE A CE1  1 
ATOM   3920 C CE2  . PHE B  1 259 ? 123.955 98.747  120.281 1.00 63.20  ? 259 PHE A CE2  1 
ATOM   3921 C CZ   . PHE B  1 259 ? 123.037 99.223  121.187 1.00 62.77  ? 259 PHE A CZ   1 
ATOM   3922 N N    . ALA B  1 260 ? 125.325 101.764 116.595 1.00 61.96  ? 260 ALA A N    1 
ATOM   3923 C CA   . ALA B  1 260 ? 126.639 102.212 117.039 1.00 64.92  ? 260 ALA A CA   1 
ATOM   3924 C C    . ALA B  1 260 ? 126.756 103.728 116.967 1.00 69.19  ? 260 ALA A C    1 
ATOM   3925 O O    . ALA B  1 260 ? 127.311 104.357 117.876 1.00 78.36  ? 260 ALA A O    1 
ATOM   3926 C CB   . ALA B  1 260 ? 127.728 101.544 116.200 1.00 65.92  ? 260 ALA A CB   1 
ATOM   3927 N N    . ASN B  1 261 ? 126.240 104.331 115.898 1.00 65.34  ? 261 ASN A N    1 
ATOM   3928 C CA   . ASN B  1 261 ? 126.283 105.783 115.775 1.00 69.27  ? 261 ASN A CA   1 
ATOM   3929 C C    . ASN B  1 261 ? 125.532 106.445 116.925 1.00 71.23  ? 261 ASN A C    1 
ATOM   3930 O O    . ASN B  1 261 ? 126.027 107.396 117.545 1.00 74.23  ? 261 ASN A O    1 
ATOM   3931 C CB   . ASN B  1 261 ? 125.698 106.197 114.424 1.00 64.31  ? 261 ASN A CB   1 
ATOM   3932 C CG   . ASN B  1 261 ? 125.939 107.657 114.104 1.00 73.42  ? 261 ASN A CG   1 
ATOM   3933 O OD1  . ASN B  1 261 ? 126.902 108.257 114.577 1.00 80.44  ? 261 ASN A OD1  1 
ATOM   3934 N ND2  . ASN B  1 261 ? 125.068 108.235 113.291 1.00 69.11  ? 261 ASN A ND2  1 
ATOM   3935 N N    . PHE B  1 262 ? 124.339 105.933 117.236 1.00 63.61  ? 262 PHE A N    1 
ATOM   3936 C CA   . PHE B  1 262 ? 123.547 106.479 118.334 1.00 65.92  ? 262 PHE A CA   1 
ATOM   3937 C C    . PHE B  1 262 ? 124.304 106.389 119.656 1.00 72.45  ? 262 PHE A C    1 
ATOM   3938 O O    . PHE B  1 262 ? 124.413 107.378 120.395 1.00 74.52  ? 262 PHE A O    1 
ATOM   3939 C CB   . PHE B  1 262 ? 122.221 105.715 118.416 1.00 63.24  ? 262 PHE A CB   1 
ATOM   3940 C CG   . PHE B  1 262 ? 121.332 106.131 119.553 1.00 68.41  ? 262 PHE A CG   1 
ATOM   3941 C CD1  . PHE B  1 262 ? 120.492 107.224 119.433 1.00 73.14  ? 262 PHE A CD1  1 
ATOM   3942 C CD2  . PHE B  1 262 ? 121.318 105.415 120.735 1.00 70.68  ? 262 PHE A CD2  1 
ATOM   3943 C CE1  . PHE B  1 262 ? 119.668 107.599 120.474 1.00 71.83  ? 262 PHE A CE1  1 
ATOM   3944 C CE2  . PHE B  1 262 ? 120.496 105.789 121.779 1.00 69.33  ? 262 PHE A CE2  1 
ATOM   3945 C CZ   . PHE B  1 262 ? 119.673 106.881 121.647 1.00 66.22  ? 262 PHE A CZ   1 
ATOM   3946 N N    . VAL B  1 263 ? 124.864 105.216 119.951 1.00 68.39  ? 263 VAL A N    1 
ATOM   3947 C CA   . VAL B  1 263 ? 125.557 105.022 121.221 1.00 62.53  ? 263 VAL A CA   1 
ATOM   3948 C C    . VAL B  1 263 ? 126.750 105.965 121.333 1.00 63.21  ? 263 VAL A C    1 
ATOM   3949 O O    . VAL B  1 263 ? 126.955 106.631 122.360 1.00 73.76  ? 263 VAL A O    1 
ATOM   3950 C CB   . VAL B  1 263 ? 125.987 103.552 121.371 1.00 55.17  ? 263 VAL A CB   1 
ATOM   3951 C CG1  . VAL B  1 263 ? 126.891 103.384 122.575 1.00 64.20  ? 263 VAL A CG1  1 
ATOM   3952 C CG2  . VAL B  1 263 ? 124.771 102.656 121.483 1.00 59.42  ? 263 VAL A CG2  1 
ATOM   3953 N N    . PHE B  1 264 ? 127.561 106.031 120.270 1.00 58.06  ? 264 PHE A N    1 
ATOM   3954 C CA   . PHE B  1 264 ? 128.760 106.862 120.313 1.00 58.30  ? 264 PHE A CA   1 
ATOM   3955 C C    . PHE B  1 264 ? 128.409 108.328 120.506 1.00 60.76  ? 264 PHE A C    1 
ATOM   3956 O O    . PHE B  1 264 ? 129.021 109.022 121.331 1.00 71.53  ? 264 PHE A O    1 
ATOM   3957 C CB   . PHE B  1 264 ? 129.571 106.666 119.033 1.00 58.59  ? 264 PHE A CB   1 
ATOM   3958 C CG   . PHE B  1 264 ? 130.341 105.378 118.992 1.00 63.76  ? 264 PHE A CG   1 
ATOM   3959 C CD1  . PHE B  1 264 ? 130.873 104.837 120.147 1.00 66.76  ? 264 PHE A CD1  1 
ATOM   3960 C CD2  . PHE B  1 264 ? 130.527 104.705 117.799 1.00 62.23  ? 264 PHE A CD2  1 
ATOM   3961 C CE1  . PHE B  1 264 ? 131.581 103.653 120.111 1.00 66.33  ? 264 PHE A CE1  1 
ATOM   3962 C CE2  . PHE B  1 264 ? 131.231 103.522 117.759 1.00 61.90  ? 264 PHE A CE2  1 
ATOM   3963 C CZ   . PHE B  1 264 ? 131.760 102.996 118.913 1.00 60.96  ? 264 PHE A CZ   1 
ATOM   3964 N N    . ILE B  1 265 ? 127.418 108.822 119.763 1.00 59.66  ? 265 ILE A N    1 
ATOM   3965 C CA   . ILE B  1 265 ? 127.069 110.234 119.880 1.00 61.74  ? 265 ILE A CA   1 
ATOM   3966 C C    . ILE B  1 265 ? 126.560 110.548 121.281 1.00 64.86  ? 265 ILE A C    1 
ATOM   3967 O O    . ILE B  1 265 ? 126.933 111.566 121.881 1.00 69.92  ? 265 ILE A O    1 
ATOM   3968 C CB   . ILE B  1 265 ? 126.050 110.634 118.799 1.00 58.30  ? 265 ILE A CB   1 
ATOM   3969 C CG1  . ILE B  1 265 ? 126.689 110.524 117.415 1.00 58.91  ? 265 ILE A CG1  1 
ATOM   3970 C CG2  . ILE B  1 265 ? 125.582 112.054 119.029 1.00 60.63  ? 265 ILE A CG2  1 
ATOM   3971 C CD1  . ILE B  1 265 ? 125.784 110.951 116.287 1.00 61.41  ? 265 ILE A CD1  1 
ATOM   3972 N N    . LEU B  1 266 ? 125.709 109.676 121.832 1.00 58.60  ? 266 LEU A N    1 
ATOM   3973 C CA   . LEU B  1 266 ? 125.188 109.920 123.174 1.00 59.23  ? 266 LEU A CA   1 
ATOM   3974 C C    . LEU B  1 266 ? 126.314 110.000 124.200 1.00 65.50  ? 266 LEU A C    1 
ATOM   3975 O O    . LEU B  1 266 ? 126.388 110.954 124.995 1.00 72.53  ? 266 LEU A O    1 
ATOM   3976 C CB   . LEU B  1 266 ? 124.192 108.822 123.547 1.00 58.97  ? 266 LEU A CB   1 
ATOM   3977 C CG   . LEU B  1 266 ? 123.625 108.838 124.967 1.00 59.69  ? 266 LEU A CG   1 
ATOM   3978 C CD1  . LEU B  1 266 ? 122.899 110.138 125.240 1.00 61.04  ? 266 LEU A CD1  1 
ATOM   3979 C CD2  . LEU B  1 266 ? 122.703 107.652 125.180 1.00 59.93  ? 266 LEU A CD2  1 
ATOM   3980 N N    . MET B  1 267 ? 127.215 109.011 124.190 1.00 64.54  ? 267 MET A N    1 
ATOM   3981 C CA   . MET B  1 267 ? 128.285 108.999 125.183 1.00 61.64  ? 267 MET A CA   1 
ATOM   3982 C C    . MET B  1 267 ? 129.190 110.219 125.038 1.00 67.88  ? 267 MET A C    1 
ATOM   3983 O O    . MET B  1 267 ? 129.566 110.851 126.039 1.00 80.26  ? 267 MET A O    1 
ATOM   3984 C CB   . MET B  1 267 ? 129.096 107.712 125.060 1.00 64.67  ? 267 MET A CB   1 
ATOM   3985 C CG   . MET B  1 267 ? 128.260 106.446 125.088 1.00 71.33  ? 267 MET A CG   1 
ATOM   3986 S SD   . MET B  1 267 ? 129.191 105.000 125.622 1.00 99.47  ? 267 MET A SD   1 
ATOM   3987 C CE   . MET B  1 267 ? 130.463 104.927 124.367 1.00 71.91  ? 267 MET A CE   1 
ATOM   3988 N N    . GLY B  1 268 ? 129.542 110.574 123.801 1.00 60.01  ? 268 GLY A N    1 
ATOM   3989 C CA   . GLY B  1 268 ? 130.398 111.728 123.599 1.00 58.56  ? 268 GLY A CA   1 
ATOM   3990 C C    . GLY B  1 268 ? 129.768 113.017 124.088 1.00 57.98  ? 268 GLY A C    1 
ATOM   3991 O O    . GLY B  1 268 ? 130.432 113.841 124.725 1.00 61.24  ? 268 GLY A O    1 
ATOM   3992 N N    . VAL B  1 269 ? 128.478 113.208 123.803 1.00 57.49  ? 269 VAL A N    1 
ATOM   3993 C CA   . VAL B  1 269 ? 127.809 114.427 124.246 1.00 57.96  ? 269 VAL A CA   1 
ATOM   3994 C C    . VAL B  1 269 ? 127.803 114.513 125.765 1.00 63.74  ? 269 VAL A C    1 
ATOM   3995 O O    . VAL B  1 269 ? 128.093 115.569 126.344 1.00 73.57  ? 269 VAL A O    1 
ATOM   3996 C CB   . VAL B  1 269 ? 126.382 114.496 123.673 1.00 58.48  ? 269 VAL A CB   1 
ATOM   3997 C CG1  . VAL B  1 269 ? 125.614 115.629 124.322 1.00 62.40  ? 269 VAL A CG1  1 
ATOM   3998 C CG2  . VAL B  1 269 ? 126.423 114.675 122.168 1.00 61.98  ? 269 VAL A CG2  1 
ATOM   3999 N N    . CYS B  1 270 ? 127.485 113.403 126.437 1.00 65.50  ? 270 CYS A N    1 
ATOM   4000 C CA   . CYS B  1 270 ? 127.481 113.424 127.897 1.00 62.97  ? 270 CYS A CA   1 
ATOM   4001 C C    . CYS B  1 270 ? 128.851 113.813 128.447 1.00 69.91  ? 270 CYS A C    1 
ATOM   4002 O O    . CYS B  1 270 ? 128.968 114.709 129.301 1.00 75.47  ? 270 CYS A O    1 
ATOM   4003 C CB   . CYS B  1 270 ? 127.050 112.062 128.441 1.00 62.04  ? 270 CYS A CB   1 
ATOM   4004 S SG   . CYS B  1 270 ? 125.321 111.649 128.135 1.00 86.56  ? 270 CYS A SG   1 
ATOM   4005 N N    . CYS B  1 271 ? 129.908 113.166 127.946 1.00 69.40  ? 271 CYS A N    1 
ATOM   4006 C CA   . CYS B  1 271 ? 131.241 113.436 128.478 1.00 61.70  ? 271 CYS A CA   1 
ATOM   4007 C C    . CYS B  1 271 ? 131.661 114.883 128.236 1.00 68.74  ? 271 CYS A C    1 
ATOM   4008 O O    . CYS B  1 271 ? 132.212 115.538 129.135 1.00 77.20  ? 271 CYS A O    1 
ATOM   4009 C CB   . CYS B  1 271 ? 132.258 112.473 127.867 1.00 64.03  ? 271 CYS A CB   1 
ATOM   4010 S SG   . CYS B  1 271 ? 132.058 110.757 128.392 1.00 89.64  ? 271 CYS A SG   1 
ATOM   4011 N N    . ILE B  1 272 ? 131.402 115.406 127.037 1.00 61.51  ? 272 ILE A N    1 
ATOM   4012 C CA   . ILE B  1 272 ? 131.838 116.767 126.730 1.00 59.00  ? 272 ILE A CA   1 
ATOM   4013 C C    . ILE B  1 272 ? 131.079 117.785 127.569 1.00 64.05  ? 272 ILE A C    1 
ATOM   4014 O O    . ILE B  1 272 ? 131.662 118.772 128.046 1.00 65.86  ? 272 ILE A O    1 
ATOM   4015 C CB   . ILE B  1 272 ? 131.698 117.050 125.227 1.00 61.13  ? 272 ILE A CB   1 
ATOM   4016 C CG1  . ILE B  1 272 ? 132.751 116.267 124.446 1.00 62.30  ? 272 ILE A CG1  1 
ATOM   4017 C CG2  . ILE B  1 272 ? 131.850 118.531 124.956 1.00 64.65  ? 272 ILE A CG2  1 
ATOM   4018 C CD1  . ILE B  1 272 ? 134.161 116.718 124.722 1.00 53.50  ? 272 ILE A CD1  1 
ATOM   4019 N N    . TYR B  1 273 ? 129.773 117.587 127.764 1.00 72.01  ? 273 TYR A N    1 
ATOM   4020 C CA   . TYR B  1 273 ? 129.024 118.522 128.595 1.00 69.51  ? 273 TYR A CA   1 
ATOM   4021 C C    . TYR B  1 273 ? 129.538 118.521 130.031 1.00 74.04  ? 273 TYR A C    1 
ATOM   4022 O O    . TYR B  1 273 ? 129.686 119.587 130.656 1.00 80.68  ? 273 TYR A O    1 
ATOM   4023 C CB   . TYR B  1 273 ? 127.535 118.184 128.549 1.00 70.31  ? 273 TYR A CB   1 
ATOM   4024 C CG   . TYR B  1 273 ? 126.631 119.391 128.606 1.00 79.88  ? 273 TYR A CG   1 
ATOM   4025 C CD1  . TYR B  1 273 ? 126.536 120.258 127.525 1.00 76.52  ? 273 TYR A CD1  1 
ATOM   4026 C CD2  . TYR B  1 273 ? 125.869 119.663 129.730 1.00 81.15  ? 273 TYR A CD2  1 
ATOM   4027 C CE1  . TYR B  1 273 ? 125.714 121.362 127.569 1.00 77.75  ? 273 TYR A CE1  1 
ATOM   4028 C CE2  . TYR B  1 273 ? 125.042 120.767 129.782 1.00 81.59  ? 273 TYR A CE2  1 
ATOM   4029 C CZ   . TYR B  1 273 ? 124.968 121.614 128.698 1.00 82.30  ? 273 TYR A CZ   1 
ATOM   4030 O OH   . TYR B  1 273 ? 124.145 122.713 128.744 1.00 81.14  ? 273 TYR A OH   1 
ATOM   4031 N N    . SER B  1 274 ? 129.838 117.336 130.572 1.00 66.43  ? 274 SER A N    1 
ATOM   4032 C CA   . SER B  1 274 ? 130.398 117.280 131.921 1.00 64.23  ? 274 SER A CA   1 
ATOM   4033 C C    . SER B  1 274 ? 131.730 118.019 131.996 1.00 67.17  ? 274 SER A C    1 
ATOM   4034 O O    . SER B  1 274 ? 131.992 118.761 132.958 1.00 77.27  ? 274 SER A O    1 
ATOM   4035 C CB   . SER B  1 274 ? 130.556 115.828 132.358 1.00 72.20  ? 274 SER A CB   1 
ATOM   4036 O OG   . SER B  1 274 ? 129.314 115.156 132.342 1.00 75.30  ? 274 SER A OG   1 
ATOM   4037 N N    . LEU B  1 275 ? 132.583 117.835 130.988 1.00 59.67  ? 275 LEU A N    1 
ATOM   4038 C CA   . LEU B  1 275 ? 133.868 118.531 130.981 1.00 63.32  ? 275 LEU A CA   1 
ATOM   4039 C C    . LEU B  1 275 ? 133.676 120.041 130.957 1.00 69.94  ? 275 LEU A C    1 
ATOM   4040 O O    . LEU B  1 275 ? 134.385 120.780 131.654 1.00 74.71  ? 275 LEU A O    1 
ATOM   4041 C CB   . LEU B  1 275 ? 134.710 118.078 129.791 1.00 56.46  ? 275 LEU A CB   1 
ATOM   4042 C CG   . LEU B  1 275 ? 136.087 118.726 129.678 1.00 55.26  ? 275 LEU A CG   1 
ATOM   4043 C CD1  . LEU B  1 275 ? 136.899 118.460 130.926 1.00 57.03  ? 275 LEU A CD1  1 
ATOM   4044 C CD2  . LEU B  1 275 ? 136.813 118.227 128.443 1.00 59.63  ? 275 LEU A CD2  1 
ATOM   4045 N N    . PHE B  1 276 ? 132.723 120.526 130.154 1.00 62.01  ? 276 PHE A N    1 
ATOM   4046 C CA   . PHE B  1 276 ? 132.475 121.962 130.104 1.00 53.16  ? 276 PHE A CA   1 
ATOM   4047 C C    . PHE B  1 276 ? 132.048 122.493 131.465 1.00 56.00  ? 276 PHE A C    1 
ATOM   4048 O O    . PHE B  1 276 ? 132.521 123.549 131.904 1.00 64.89  ? 276 PHE A O    1 
ATOM   4049 C CB   . PHE B  1 276 ? 131.418 122.283 129.050 1.00 52.92  ? 276 PHE A CB   1 
ATOM   4050 C CG   . PHE B  1 276 ? 131.940 122.275 127.641 1.00 62.93  ? 276 PHE A CG   1 
ATOM   4051 C CD1  . PHE B  1 276 ? 133.292 122.137 127.387 1.00 63.19  ? 276 PHE A CD1  1 
ATOM   4052 C CD2  . PHE B  1 276 ? 131.078 122.415 126.568 1.00 59.02  ? 276 PHE A CD2  1 
ATOM   4053 C CE1  . PHE B  1 276 ? 133.772 122.134 126.093 1.00 61.29  ? 276 PHE A CE1  1 
ATOM   4054 C CE2  . PHE B  1 276 ? 131.552 122.411 125.276 1.00 56.04  ? 276 PHE A CE2  1 
ATOM   4055 C CZ   . PHE B  1 276 ? 132.899 122.270 125.038 1.00 55.72  ? 276 PHE A CZ   1 
ATOM   4056 N N    . ASN B  1 277 ? 131.158 121.774 132.156 1.00 62.66  ? 277 ASN A N    1 
ATOM   4057 C CA   . ASN B  1 277 ? 130.725 122.242 133.472 1.00 61.54  ? 277 ASN A CA   1 
ATOM   4058 C C    . ASN B  1 277 ? 131.890 122.301 134.463 1.00 64.42  ? 277 ASN A C    1 
ATOM   4059 O O    . ASN B  1 277 ? 132.033 123.280 135.216 1.00 71.90  ? 277 ASN A O    1 
ATOM   4060 C CB   . ASN B  1 277 ? 129.609 121.350 134.008 1.00 63.48  ? 277 ASN A CB   1 
ATOM   4061 C CG   . ASN B  1 277 ? 128.282 121.607 133.320 1.00 72.49  ? 277 ASN A CG   1 
ATOM   4062 O OD1  . ASN B  1 277 ? 127.531 122.497 133.709 1.00 76.01  ? 277 ASN A OD1  1 
ATOM   4063 N ND2  . ASN B  1 277 ? 127.987 120.823 132.290 1.00 71.50  ? 277 ASN A ND2  1 
ATOM   4064 N N    . VAL B  1 278 ? 132.742 121.274 134.466 1.00 63.10  ? 278 VAL A N    1 
ATOM   4065 C CA   . VAL B  1 278 ? 133.868 121.271 135.399 1.00 60.48  ? 278 VAL A CA   1 
ATOM   4066 C C    . VAL B  1 278 ? 134.818 122.431 135.105 1.00 65.50  ? 278 VAL A C    1 
ATOM   4067 O O    . VAL B  1 278 ? 135.290 123.125 136.022 1.00 69.06  ? 278 VAL A O    1 
ATOM   4068 C CB   . VAL B  1 278 ? 134.593 119.915 135.357 1.00 62.45  ? 278 VAL A CB   1 
ATOM   4069 C CG1  . VAL B  1 278 ? 135.868 119.976 136.173 1.00 67.52  ? 278 VAL A CG1  1 
ATOM   4070 C CG2  . VAL B  1 278 ? 133.683 118.819 135.874 1.00 60.02  ? 278 VAL A CG2  1 
ATOM   4071 N N    . ILE B  1 279 ? 135.111 122.666 133.825 1.00 60.30  ? 279 ILE A N    1 
ATOM   4072 C CA   . ILE B  1 279 ? 136.007 123.764 133.476 1.00 57.73  ? 279 ILE A CA   1 
ATOM   4073 C C    . ILE B  1 279 ? 135.394 125.101 133.873 1.00 64.29  ? 279 ILE A C    1 
ATOM   4074 O O    . ILE B  1 279 ? 136.105 126.029 134.279 1.00 67.00  ? 279 ILE A O    1 
ATOM   4075 C CB   . ILE B  1 279 ? 136.357 123.722 131.979 1.00 54.50  ? 279 ILE A CB   1 
ATOM   4076 C CG1  . ILE B  1 279 ? 137.176 122.475 131.659 1.00 53.81  ? 279 ILE A CG1  1 
ATOM   4077 C CG2  . ILE B  1 279 ? 137.121 124.968 131.581 1.00 61.14  ? 279 ILE A CG2  1 
ATOM   4078 C CD1  . ILE B  1 279 ? 137.676 122.429 130.238 1.00 59.15  ? 279 ILE A CD1  1 
ATOM   4079 N N    . SER B  1 280 ? 134.070 125.225 133.758 1.00 62.32  ? 280 SER A N    1 
ATOM   4080 C CA   . SER B  1 280 ? 133.419 126.458 134.188 1.00 54.10  ? 280 SER A CA   1 
ATOM   4081 C C    . SER B  1 280 ? 133.602 126.684 135.682 1.00 56.99  ? 280 SER A C    1 
ATOM   4082 O O    . SER B  1 280 ? 133.855 127.815 136.124 1.00 62.80  ? 280 SER A O    1 
ATOM   4083 C CB   . SER B  1 280 ? 131.935 126.417 133.834 1.00 58.34  ? 280 SER A CB   1 
ATOM   4084 O OG   . SER B  1 280 ? 131.172 127.114 134.801 1.00 71.56  ? 280 SER A OG   1 
ATOM   4085 N N    . ILE B  1 281 ? 133.484 125.621 136.480 1.00 67.26  ? 281 ILE A N    1 
ATOM   4086 C CA   . ILE B  1 281 ? 133.713 125.759 137.920 1.00 64.31  ? 281 ILE A CA   1 
ATOM   4087 C C    . ILE B  1 281 ? 135.132 126.252 138.188 1.00 66.11  ? 281 ILE A C    1 
ATOM   4088 O O    . ILE B  1 281 ? 135.361 127.161 139.006 1.00 71.64  ? 281 ILE A O    1 
ATOM   4089 C CB   . ILE B  1 281 ? 133.437 124.429 138.640 1.00 63.76  ? 281 ILE A CB   1 
ATOM   4090 C CG1  . ILE B  1 281 ? 131.950 124.090 138.583 1.00 65.89  ? 281 ILE A CG1  1 
ATOM   4091 C CG2  . ILE B  1 281 ? 133.915 124.496 140.076 1.00 63.60  ? 281 ILE A CG2  1 
ATOM   4092 C CD1  . ILE B  1 281 ? 131.591 122.809 139.296 1.00 69.96  ? 281 ILE A CD1  1 
ATOM   4093 N N    . LEU B  1 282 ? 136.111 125.659 137.499 1.00 69.03  ? 282 LEU A N    1 
ATOM   4094 C CA   . LEU B  1 282 ? 137.495 126.088 137.702 1.00 64.11  ? 282 LEU A CA   1 
ATOM   4095 C C    . LEU B  1 282 ? 137.688 127.554 137.320 1.00 65.45  ? 282 LEU A C    1 
ATOM   4096 O O    . LEU B  1 282 ? 138.387 128.304 138.020 1.00 66.84  ? 282 LEU A O    1 
ATOM   4097 C CB   . LEU B  1 282 ? 138.444 125.198 136.901 1.00 67.54  ? 282 LEU A CB   1 
ATOM   4098 C CG   . LEU B  1 282 ? 138.760 123.836 137.518 1.00 71.56  ? 282 LEU A CG   1 
ATOM   4099 C CD1  . LEU B  1 282 ? 139.793 123.101 136.685 1.00 72.72  ? 282 LEU A CD1  1 
ATOM   4100 C CD2  . LEU B  1 282 ? 139.242 123.999 138.946 1.00 67.27  ? 282 LEU A CD2  1 
ATOM   4101 N N    . ILE B  1 283 ? 137.083 127.985 136.210 1.00 64.30  ? 283 ILE A N    1 
ATOM   4102 C CA   . ILE B  1 283 ? 137.218 129.376 135.782 1.00 61.86  ? 283 ILE A CA   1 
ATOM   4103 C C    . ILE B  1 283 ? 136.612 130.315 136.813 1.00 62.22  ? 283 ILE A C    1 
ATOM   4104 O O    . ILE B  1 283 ? 137.148 131.401 137.077 1.00 61.44  ? 283 ILE A O    1 
ATOM   4105 C CB   . ILE B  1 283 ? 136.589 129.577 134.392 1.00 55.25  ? 283 ILE A CB   1 
ATOM   4106 C CG1  . ILE B  1 283 ? 137.383 128.823 133.327 1.00 55.63  ? 283 ILE A CG1  1 
ATOM   4107 C CG2  . ILE B  1 283 ? 136.520 131.051 134.055 1.00 49.85  ? 283 ILE A CG2  1 
ATOM   4108 C CD1  . ILE B  1 283 ? 136.843 129.000 131.931 1.00 56.69  ? 283 ILE A CD1  1 
ATOM   4109 N N    . LYS B  1 284 ? 135.479 129.927 137.403 1.00 68.88  ? 284 LYS A N    1 
ATOM   4110 C CA   . LYS B  1 284 ? 134.874 130.763 138.437 1.00 63.66  ? 284 LYS A CA   1 
ATOM   4111 C C    . LYS B  1 284 ? 135.798 130.903 139.640 1.00 63.38  ? 284 LYS A C    1 
ATOM   4112 O O    . LYS B  1 284 ? 135.950 131.998 140.199 1.00 62.40  ? 284 LYS A O    1 
ATOM   4113 C CB   . LYS B  1 284 ? 133.530 130.186 138.866 1.00 64.10  ? 284 LYS A CB   1 
ATOM   4114 C CG   . LYS B  1 284 ? 133.016 130.740 140.179 1.00 59.53  ? 284 LYS A CG   1 
ATOM   4115 C CD   . LYS B  1 284 ? 131.503 130.672 140.252 1.00 62.69  ? 284 LYS A CD   1 
ATOM   4116 C CE   . LYS B  1 284 ? 130.973 131.499 141.405 1.00 62.77  ? 284 LYS A CE   1 
ATOM   4117 N NZ   . LYS B  1 284 ? 129.489 131.462 141.476 1.00 71.43  ? 284 LYS A NZ   1 
ATOM   4118 N N    . GLN B  1 285 ? 136.425 129.792 140.037 1.00 78.01  ? 285 GLN A N    1 
ATOM   4119 C CA   . GLN B  1 285 ? 137.386 129.834 141.171 1.00 71.33  ? 285 GLN A CA   1 
ATOM   4120 C C    . GLN B  1 285 ? 138.510 130.815 140.827 1.00 70.79  ? 285 GLN A C    1 
ATOM   4121 O O    . GLN B  1 285 ? 138.861 131.638 141.695 1.00 72.56  ? 285 GLN A O    1 
ATOM   4122 C CB   . GLN B  1 285 ? 137.967 128.446 141.443 1.00 71.68  ? 285 GLN A CB   1 
ATOM   4123 C CG   . GLN B  1 285 ? 136.921 127.344 141.518 1.00 74.48  ? 285 GLN A CG   1 
ATOM   4124 C CD   . GLN B  1 285 ? 137.520 125.989 141.231 1.00 82.91  ? 285 GLN A CD   1 
ATOM   4125 O OE1  . GLN B  1 285 ? 136.840 125.069 140.784 1.00 87.61  ? 285 GLN A OE1  1 
ATOM   4126 N NE2  . GLN B  1 285 ? 138.811 125.858 141.489 1.00 83.58  ? 285 GLN A NE2  1 
ATOM   4127 N N    . SER B  1 286 ? 139.049 130.724 139.608 1.00 72.45  ? 286 SER A N    1 
ATOM   4128 C CA   . SER B  1 286 ? 140.147 131.601 139.205 1.00 68.65  ? 286 SER A CA   1 
ATOM   4129 C C    . SER B  1 286 ? 139.730 133.068 139.218 1.00 73.99  ? 286 SER A C    1 
ATOM   4130 O O    . SER B  1 286 ? 140.500 133.938 139.641 1.00 75.47  ? 286 SER A O    1 
ATOM   4131 C CB   . SER B  1 286 ? 140.656 131.198 137.823 1.00 74.95  ? 286 SER A CB   1 
ATOM   4132 O OG   . SER B  1 286 ? 139.593 130.733 137.011 1.00 81.06  ? 286 SER A OG   1 
ATOM   4133 N N    . LEU B  1 287 ? 138.516 133.366 138.745 1.00 78.39  ? 287 LEU A N    1 
ATOM   4134 C CA   . LEU B  1 287 ? 138.032 134.743 138.786 1.00 66.06  ? 287 LEU A CA   1 
ATOM   4135 C C    . LEU B  1 287 ? 137.921 135.242 140.219 1.00 67.70  ? 287 LEU A C    1 
ATOM   4136 O O    . LEU B  1 287 ? 138.254 136.400 140.511 1.00 66.66  ? 287 LEU A O    1 
ATOM   4137 C CB   . LEU B  1 287 ? 136.680 134.860 138.084 1.00 63.66  ? 287 LEU A CB   1 
ATOM   4138 C CG   . LEU B  1 287 ? 136.657 134.880 136.559 1.00 68.59  ? 287 LEU A CG   1 
ATOM   4139 C CD1  . LEU B  1 287 ? 135.244 135.123 136.070 1.00 68.14  ? 287 LEU A CD1  1 
ATOM   4140 C CD2  . LEU B  1 287 ? 137.598 135.940 136.031 1.00 71.85  ? 287 LEU A CD2  1 
ATOM   4141 N N    . ASN B  1 288 ? 137.437 134.390 141.126 1.00 84.58  ? 288 ASN A N    1 
ATOM   4142 C CA   . ASN B  1 288 ? 137.374 134.782 142.530 1.00 81.03  ? 288 ASN A CA   1 
ATOM   4143 C C    . ASN B  1 288 ? 138.757 135.122 143.066 1.00 78.86  ? 288 ASN A C    1 
ATOM   4144 O O    . ASN B  1 288 ? 138.930 136.125 143.767 1.00 78.00  ? 288 ASN A O    1 
ATOM   4145 C CB   . ASN B  1 288 ? 136.739 133.670 143.362 1.00 82.05  ? 288 ASN A CB   1 
ATOM   4146 C CG   . ASN B  1 288 ? 135.268 133.904 143.623 1.00 81.53  ? 288 ASN A CG   1 
ATOM   4147 O OD1  . ASN B  1 288 ? 134.795 135.037 143.609 1.00 82.10  ? 288 ASN A OD1  1 
ATOM   4148 N ND2  . ASN B  1 288 ? 134.534 132.825 143.871 1.00 82.72  ? 288 ASN A ND2  1 
ATOM   4149 N N    . TRP B  1 289 ? 139.758 134.305 142.737 1.00 92.81  ? 289 TRP A N    1 
ATOM   4150 C CA   . TRP B  1 289 ? 141.112 134.612 143.187 1.00 92.92  ? 289 TRP A CA   1 
ATOM   4151 C C    . TRP B  1 289 ? 141.604 135.932 142.611 1.00 92.44  ? 289 TRP A C    1 
ATOM   4152 O O    . TRP B  1 289 ? 142.227 136.735 143.320 1.00 92.21  ? 289 TRP A O    1 
ATOM   4153 C CB   . TRP B  1 289 ? 142.079 133.488 142.816 1.00 98.05  ? 289 TRP A CB   1 
ATOM   4154 C CG   . TRP B  1 289 ? 143.495 133.806 143.200 1.00 99.20  ? 289 TRP A CG   1 
ATOM   4155 C CD1  . TRP B  1 289 ? 144.054 133.684 144.437 1.00 96.09  ? 289 TRP A CD1  1 
ATOM   4156 C CD2  . TRP B  1 289 ? 144.524 134.314 142.344 1.00 99.05  ? 289 TRP A CD2  1 
ATOM   4157 N NE1  . TRP B  1 289 ? 145.371 134.076 144.406 1.00 94.66  ? 289 TRP A NE1  1 
ATOM   4158 C CE2  . TRP B  1 289 ? 145.683 134.470 143.131 1.00 96.21  ? 289 TRP A CE2  1 
ATOM   4159 C CE3  . TRP B  1 289 ? 144.582 134.653 140.988 1.00 95.64  ? 289 TRP A CE3  1 
ATOM   4160 C CZ2  . TRP B  1 289 ? 146.882 134.945 142.608 1.00 93.50  ? 289 TRP A CZ2  1 
ATOM   4161 C CZ3  . TRP B  1 289 ? 145.774 135.123 140.473 1.00 93.83  ? 289 TRP A CZ3  1 
ATOM   4162 C CH2  . TRP B  1 289 ? 146.908 135.265 141.279 1.00 93.06  ? 289 TRP A CH2  1 
ATOM   4163 N N    . ILE B  1 290 ? 141.341 136.178 141.326 1.00 94.21  ? 290 ILE A N    1 
ATOM   4164 C CA   . ILE B  1 290 ? 141.808 137.411 140.698 1.00 92.04  ? 290 ILE A CA   1 
ATOM   4165 C C    . ILE B  1 290 ? 141.187 138.621 141.389 1.00 91.47  ? 290 ILE A C    1 
ATOM   4166 O O    . ILE B  1 290 ? 141.870 139.603 141.690 1.00 87.02  ? 290 ILE A O    1 
ATOM   4167 C CB   . ILE B  1 290 ? 141.488 137.407 139.193 1.00 89.75  ? 290 ILE A CB   1 
ATOM   4168 C CG1  . ILE B  1 290 ? 142.626 136.763 138.406 1.00 91.09  ? 290 ILE A CG1  1 
ATOM   4169 C CG2  . ILE B  1 290 ? 141.257 138.820 138.699 1.00 88.11  ? 290 ILE A CG2  1 
ATOM   4170 C CD1  . ILE B  1 290 ? 142.342 136.641 136.925 1.00 90.58  ? 290 ILE A CD1  1 
ATOM   4171 N N    . LEU B  1 291 ? 139.881 138.561 141.651 1.00 100.32 ? 291 LEU A N    1 
ATOM   4172 C CA   . LEU B  1 291 ? 139.219 139.669 142.333 1.00 95.22  ? 291 LEU A CA   1 
ATOM   4173 C C    . LEU B  1 291 ? 139.765 139.854 143.742 1.00 96.97  ? 291 LEU A C    1 
ATOM   4174 O O    . LEU B  1 291 ? 139.939 140.987 144.205 1.00 94.96  ? 291 LEU A O    1 
ATOM   4175 C CB   . LEU B  1 291 ? 137.709 139.449 142.372 1.00 95.35  ? 291 LEU A CB   1 
ATOM   4176 C CG   . LEU B  1 291 ? 136.909 140.100 141.247 1.00 90.85  ? 291 LEU A CG   1 
ATOM   4177 C CD1  . LEU B  1 291 ? 135.430 139.824 141.423 1.00 92.01  ? 291 LEU A CD1  1 
ATOM   4178 C CD2  . LEU B  1 291 ? 137.177 141.591 141.216 1.00 90.18  ? 291 LEU A CD2  1 
ATOM   4179 N N    . ARG B  1 292 ? 140.040 138.752 144.444 1.00 120.18 ? 292 ARG A N    1 
ATOM   4180 C CA   . ARG B  1 292 ? 140.583 138.855 145.791 1.00 118.78 ? 292 ARG A CA   1 
ATOM   4181 C C    . ARG B  1 292 ? 141.950 139.527 145.789 1.00 118.72 ? 292 ARG A C    1 
ATOM   4182 O O    . ARG B  1 292 ? 142.236 140.372 146.646 1.00 116.58 ? 292 ARG A O    1 
ATOM   4183 C CB   . ARG B  1 292 ? 140.669 137.466 146.424 1.00 117.86 ? 292 ARG A CB   1 
ATOM   4184 C CG   . ARG B  1 292 ? 141.132 137.456 147.868 1.00 117.05 ? 292 ARG A CG   1 
ATOM   4185 C CD   . ARG B  1 292 ? 141.306 136.031 148.355 1.00 119.31 ? 292 ARG A CD   1 
ATOM   4186 N NE   . ARG B  1 292 ? 140.136 135.215 148.059 1.00 121.55 ? 292 ARG A NE   1 
ATOM   4187 C CZ   . ARG B  1 292 ? 140.082 133.899 148.210 1.00 122.10 ? 292 ARG A CZ   1 
ATOM   4188 N NH1  . ARG B  1 292 ? 141.120 133.210 148.652 1.00 121.94 ? 292 ARG A NH1  1 
ATOM   4189 N NH2  . ARG B  1 292 ? 138.958 133.256 147.905 1.00 121.19 ? 292 ARG A NH2  1 
ATOM   4190 N N    . LYS B  1 293 ? 142.808 139.165 144.832 1.00 125.28 ? 293 LYS A N    1 
ATOM   4191 C CA   . LYS B  1 293 ? 144.139 139.765 144.776 1.00 123.75 ? 293 LYS A CA   1 
ATOM   4192 C C    . LYS B  1 293 ? 144.065 141.260 144.494 1.00 122.30 ? 293 LYS A C    1 
ATOM   4193 O O    . LYS B  1 293 ? 144.759 142.054 145.137 1.00 123.43 ? 293 LYS A O    1 
ATOM   4194 C CB   . LYS B  1 293 ? 144.984 139.063 143.715 1.00 124.17 ? 293 LYS A CB   1 
ATOM   4195 C CG   . LYS B  1 293 ? 146.351 139.686 143.505 1.00 122.91 ? 293 LYS A CG   1 
ATOM   4196 C CD   . LYS B  1 293 ? 147.188 139.592 144.768 1.00 123.23 ? 293 LYS A CD   1 
ATOM   4197 C CE   . LYS B  1 293 ? 147.465 138.142 145.129 1.00 124.24 ? 293 LYS A CE   1 
ATOM   4198 N NZ   . LYS B  1 293 ? 148.227 137.443 144.060 1.00 123.61 ? 293 LYS A NZ   1 
ATOM   4199 N N    . MET B  1 294 ? 143.234 141.660 143.536 1.00 131.67 ? 294 MET A N    1 
ATOM   4200 C CA   . MET B  1 294 ? 143.108 143.070 143.200 1.00 133.67 ? 294 MET A CA   1 
ATOM   4201 C C    . MET B  1 294 ? 142.429 143.834 144.328 1.00 134.99 ? 294 MET A C    1 
ATOM   4202 O O    . MET B  1 294 ? 141.473 143.353 144.940 1.00 135.04 ? 294 MET A O    1 
ATOM   4203 C CB   . MET B  1 294 ? 142.317 143.235 141.903 1.00 134.02 ? 294 MET A CB   1 
ATOM   4204 C CG   . MET B  1 294 ? 141.812 144.647 141.657 1.00 132.84 ? 294 MET A CG   1 
ATOM   4205 S SD   . MET B  1 294 ? 140.876 144.783 140.123 1.00 138.46 ? 294 MET A SD   1 
ATOM   4206 C CE   . MET B  1 294 ? 141.790 143.661 139.070 1.00 132.63 ? 294 MET A CE   1 
ATOM   4207 N N    . ASP B  1 295 ? 142.931 145.032 144.604 1.00 141.51 ? 295 ASP A N    1 
ATOM   4208 C CA   . ASP B  1 295 ? 142.335 145.899 145.611 1.00 141.52 ? 295 ASP A CA   1 
ATOM   4209 C C    . ASP B  1 295 ? 141.854 147.202 144.984 1.00 143.09 ? 295 ASP A C    1 
ATOM   4210 O O    . ASP B  1 295 ? 141.881 147.360 143.763 1.00 142.62 ? 295 ASP A O    1 
ATOM   4211 C CB   . ASP B  1 295 ? 143.330 146.186 146.737 1.00 139.38 ? 295 ASP A CB   1 
ATOM   4212 C CG   . ASP B  1 295 ? 143.603 144.968 147.594 1.00 139.96 ? 295 ASP A CG   1 
ATOM   4213 O OD1  . ASP B  1 295 ? 142.936 143.934 147.392 1.00 138.65 ? 295 ASP A OD1  1 
ATOM   4214 O OD2  . ASP B  1 295 ? 144.491 145.044 148.469 1.00 142.15 ? 295 ASP A OD2  1 
HETATM 4215 C C1   . HEX C  2 .   ? 122.176 144.315 138.470 1.00 20.00  ? 401 HEX U C1   1 
HETATM 4216 C C2   . HEX C  2 .   ? 122.405 144.262 137.016 1.00 20.00  ? 401 HEX U C2   1 
HETATM 4217 C C3   . HEX C  2 .   ? 121.264 143.670 136.323 1.00 20.00  ? 401 HEX U C3   1 
HETATM 4218 C C4   . HEX C  2 .   ? 121.687 143.485 134.919 1.00 20.00  ? 401 HEX U C4   1 
HETATM 4219 C C5   . HEX C  2 .   ? 120.776 143.708 133.737 1.00 20.00  ? 401 HEX U C5   1 
HETATM 4220 C C6   . HEX C  2 .   ? 119.693 142.685 133.547 1.00 20.00  ? 401 HEX U C6   1 
HETATM 4221 H H11  . HEX C  2 .   ? 121.163 144.653 138.653 1.00 20.00  ? 401 HEX U H11  1 
HETATM 4222 H H12  . HEX C  2 .   ? 122.880 144.999 138.923 1.00 20.00  ? 401 HEX U H12  1 
HETATM 4223 H H13  . HEX C  2 .   ? 122.306 143.324 138.887 1.00 20.00  ? 401 HEX U H13  1 
HETATM 4224 H H21  . HEX C  2 .   ? 123.285 143.664 136.817 1.00 20.00  ? 401 HEX U H21  1 
HETATM 4225 H H22  . HEX C  2 .   ? 122.560 145.266 136.647 1.00 20.00  ? 401 HEX U H22  1 
HETATM 4226 H H31  . HEX C  2 .   ? 120.416 144.340 136.365 1.00 20.00  ? 401 HEX U H31  1 
HETATM 4227 H H32  . HEX C  2 .   ? 121.013 142.718 136.770 1.00 20.00  ? 401 HEX U H32  1 
HETATM 4228 H H41  . HEX C  2 .   ? 122.540 144.131 134.768 1.00 20.00  ? 401 HEX U H41  1 
HETATM 4229 H H42  . HEX C  2 .   ? 122.041 142.466 134.840 1.00 20.00  ? 401 HEX U H42  1 
HETATM 4230 H H51  . HEX C  2 .   ? 120.308 144.674 133.858 1.00 20.00  ? 401 HEX U H51  1 
HETATM 4231 H H52  . HEX C  2 .   ? 121.383 143.726 132.843 1.00 20.00  ? 401 HEX U H52  1 
HETATM 4232 H H61  . HEX C  2 .   ? 119.312 142.749 132.535 1.00 20.00  ? 401 HEX U H61  1 
HETATM 4233 H H62  . HEX C  2 .   ? 118.895 142.878 134.252 1.00 20.00  ? 401 HEX U H62  1 
HETATM 4234 H H63  . HEX C  2 .   ? 120.104 141.699 133.724 1.00 20.00  ? 401 HEX U H63  1 
HETATM 4235 C C1   . D12 D  3 .   ? 118.797 148.282 120.342 1.00 20.00  ? 402 D12 U C1   1 
HETATM 4236 C C2   . D12 D  3 .   ? 119.459 149.095 119.242 1.00 20.00  ? 402 D12 U C2   1 
HETATM 4237 C C3   . D12 D  3 .   ? 118.447 149.912 118.455 1.00 20.00  ? 402 D12 U C3   1 
HETATM 4238 C C4   . D12 D  3 .   ? 118.997 150.394 117.120 1.00 20.00  ? 402 D12 U C4   1 
HETATM 4239 C C5   . D12 D  3 .   ? 118.220 149.816 115.946 1.00 20.00  ? 402 D12 U C5   1 
HETATM 4240 C C6   . D12 D  3 .   ? 118.425 150.634 114.683 1.00 20.00  ? 402 D12 U C6   1 
HETATM 4241 C C7   . D12 D  3 .   ? 118.038 149.860 113.433 1.00 20.00  ? 402 D12 U C7   1 
HETATM 4242 C C8   . D12 D  3 .   ? 117.352 150.762 112.425 1.00 20.00  ? 402 D12 U C8   1 
HETATM 4243 C C9   . D12 D  3 .   ? 117.792 150.507 110.995 1.00 20.00  ? 402 D12 U C9   1 
HETATM 4244 C C10  . D12 D  3 .   ? 117.130 151.502 110.050 1.00 20.00  ? 402 D12 U C10  1 
HETATM 4245 C C11  . D12 D  3 .   ? 117.067 151.012 108.610 1.00 20.00  ? 402 D12 U C11  1 
HETATM 4246 C C12  . D12 D  3 .   ? 116.204 151.906 107.725 1.00 20.00  ? 402 D12 U C12  1 
HETATM 4247 H H11  . D12 D  3 .   ? 118.468 147.330 119.936 1.00 20.00  ? 402 D12 U H11  1 
HETATM 4248 H H12  . D12 D  3 .   ? 117.940 148.828 120.724 1.00 20.00  ? 402 D12 U H12  1 
HETATM 4249 H H13  . D12 D  3 .   ? 119.509 148.110 121.142 1.00 20.00  ? 402 D12 U H13  1 
HETATM 4250 H H21  . D12 D  3 .   ? 119.967 148.419 118.562 1.00 20.00  ? 402 D12 U H21  1 
HETATM 4251 H H22  . D12 D  3 .   ? 120.187 149.765 119.685 1.00 20.00  ? 402 D12 U H22  1 
HETATM 4252 H H31  . D12 D  3 .   ? 118.154 150.772 119.048 1.00 20.00  ? 402 D12 U H31  1 
HETATM 4253 H H32  . D12 D  3 .   ? 117.572 149.297 118.273 1.00 20.00  ? 402 D12 U H32  1 
HETATM 4254 H H41  . D12 D  3 .   ? 120.033 150.086 117.036 1.00 20.00  ? 402 D12 U H41  1 
HETATM 4255 H H42  . D12 D  3 .   ? 118.943 151.476 117.079 1.00 20.00  ? 402 D12 U H42  1 
HETATM 4256 H H51  . D12 D  3 .   ? 118.554 148.800 115.767 1.00 20.00  ? 402 D12 U H51  1 
HETATM 4257 H H52  . D12 D  3 .   ? 117.163 149.807 116.190 1.00 20.00  ? 402 D12 U H52  1 
HETATM 4258 H H61  . D12 D  3 .   ? 117.819 151.531 114.747 1.00 20.00  ? 402 D12 U H61  1 
HETATM 4259 H H62  . D12 D  3 .   ? 119.469 150.917 114.614 1.00 20.00  ? 402 D12 U H62  1 
HETATM 4260 H H71  . D12 D  3 .   ? 118.933 149.443 112.983 1.00 20.00  ? 402 D12 U H71  1 
HETATM 4261 H H72  . D12 D  3 .   ? 117.368 149.053 113.710 1.00 20.00  ? 402 D12 U H72  1 
HETATM 4262 H H81  . D12 D  3 .   ? 117.572 151.794 112.671 1.00 20.00  ? 402 D12 U H81  1 
HETATM 4263 H H82  . D12 D  3 .   ? 116.280 150.606 112.491 1.00 20.00  ? 402 D12 U H82  1 
HETATM 4264 H H91  . D12 D  3 .   ? 117.508 149.501 110.708 1.00 20.00  ? 402 D12 U H91  1 
HETATM 4265 H H92  . D12 D  3 .   ? 118.870 150.610 110.928 1.00 20.00  ? 402 D12 U H92  1 
HETATM 4266 H H101 . D12 D  3 .   ? 116.119 151.689 110.397 1.00 20.00  ? 402 D12 U H101 1 
HETATM 4267 H H102 . D12 D  3 .   ? 117.687 152.432 110.078 1.00 20.00  ? 402 D12 U H102 1 
HETATM 4268 H H111 . D12 D  3 .   ? 116.657 150.008 108.601 1.00 20.00  ? 402 D12 U H111 1 
HETATM 4269 H H112 . D12 D  3 .   ? 118.073 150.986 108.207 1.00 20.00  ? 402 D12 U H112 1 
HETATM 4270 H H121 . D12 D  3 .   ? 116.153 152.899 108.163 1.00 20.00  ? 402 D12 U H121 1 
HETATM 4271 H H122 . D12 D  3 .   ? 116.642 151.965 106.734 1.00 20.00  ? 402 D12 U H122 1 
HETATM 4272 H H123 . D12 D  3 .   ? 115.204 151.487 107.656 1.00 20.00  ? 402 D12 U H123 1 
HETATM 4273 C C1   . HEX E  2 .   ? 136.104 148.544 117.778 1.00 20.00  ? 403 HEX U C1   1 
HETATM 4274 C C2   . HEX E  2 .   ? 136.764 148.841 116.435 1.00 20.00  ? 403 HEX U C2   1 
HETATM 4275 C C3   . HEX E  2 .   ? 136.142 148.014 115.322 1.00 20.00  ? 403 HEX U C3   1 
HETATM 4276 C C4   . HEX E  2 .   ? 136.490 148.512 113.933 1.00 20.00  ? 403 HEX U C4   1 
HETATM 4277 C C5   . HEX E  2 .   ? 135.439 148.023 112.947 1.00 20.00  ? 403 HEX U C5   1 
HETATM 4278 C C6   . HEX E  2 .   ? 135.945 148.020 111.512 1.00 20.00  ? 403 HEX U C6   1 
HETATM 4279 H H11  . HEX E  2 .   ? 135.409 147.722 117.659 1.00 20.00  ? 403 HEX U H11  1 
HETATM 4280 H H12  . HEX E  2 .   ? 135.570 149.423 118.112 1.00 20.00  ? 403 HEX U H12  1 
HETATM 4281 H H13  . HEX E  2 .   ? 136.855 148.283 118.509 1.00 20.00  ? 403 HEX U H13  1 
HETATM 4282 H H21  . HEX E  2 .   ? 137.820 148.616 116.495 1.00 20.00  ? 403 HEX U H21  1 
HETATM 4283 H H22  . HEX E  2 .   ? 136.632 149.889 116.203 1.00 20.00  ? 403 HEX U H22  1 
HETATM 4284 H H31  . HEX E  2 .   ? 135.074 148.078 115.416 1.00 20.00  ? 403 HEX U H31  1 
HETATM 4285 H H32  . HEX E  2 .   ? 136.446 146.982 115.416 1.00 20.00  ? 403 HEX U H32  1 
HETATM 4286 H H41  . HEX E  2 .   ? 136.503 149.593 113.935 1.00 20.00  ? 403 HEX U H41  1 
HETATM 4287 H H42  . HEX E  2 .   ? 137.462 148.133 113.650 1.00 20.00  ? 403 HEX U H42  1 
HETATM 4288 H H51  . HEX E  2 .   ? 135.147 147.018 113.226 1.00 20.00  ? 403 HEX U H51  1 
HETATM 4289 H H52  . HEX E  2 .   ? 134.575 148.670 113.016 1.00 20.00  ? 403 HEX U H52  1 
HETATM 4290 H H61  . HEX E  2 .   ? 137.023 147.919 111.511 1.00 20.00  ? 403 HEX U H61  1 
HETATM 4291 H H62  . HEX E  2 .   ? 135.669 148.950 111.033 1.00 20.00  ? 403 HEX U H62  1 
HETATM 4292 H H63  . HEX E  2 .   ? 135.501 147.191 110.978 1.00 20.00  ? 403 HEX U H63  1 
HETATM 4293 C C1   . OCT F  4 .   ? 112.299 148.507 117.390 1.00 20.00  ? 404 OCT U C1   1 
HETATM 4294 C C2   . OCT F  4 .   ? 112.955 148.217 116.049 1.00 20.00  ? 404 OCT U C2   1 
HETATM 4295 C C3   . OCT F  4 .   ? 112.683 149.314 115.035 1.00 20.00  ? 404 OCT U C3   1 
HETATM 4296 C C4   . OCT F  4 .   ? 111.371 149.090 114.299 1.00 20.00  ? 404 OCT U C4   1 
HETATM 4297 C C5   . OCT F  4 .   ? 111.590 148.671 112.856 1.00 20.00  ? 404 OCT U C5   1 
HETATM 4298 C C6   . OCT F  4 .   ? 111.693 149.858 111.922 1.00 20.00  ? 404 OCT U C6   1 
HETATM 4299 C C7   . OCT F  4 .   ? 112.019 149.403 110.512 1.00 20.00  ? 404 OCT U C7   1 
HETATM 4300 C C8   . OCT F  4 .   ? 111.473 150.357 109.461 1.00 20.00  ? 404 OCT U C8   1 
HETATM 4301 H H11  . OCT F  4 .   ? 111.248 148.715 117.236 1.00 20.00  ? 404 OCT U H11  1 
HETATM 4302 H H12  . OCT F  4 .   ? 112.407 147.647 118.038 1.00 20.00  ? 404 OCT U H12  1 
HETATM 4303 H H13  . OCT F  4 .   ? 112.776 149.367 117.843 1.00 20.00  ? 404 OCT U H13  1 
HETATM 4304 H H21  . OCT F  4 .   ? 112.570 147.281 115.663 1.00 20.00  ? 404 OCT U H21  1 
HETATM 4305 H H22  . OCT F  4 .   ? 114.025 148.128 116.192 1.00 20.00  ? 404 OCT U H22  1 
HETATM 4306 H H31  . OCT F  4 .   ? 112.638 150.264 115.553 1.00 20.00  ? 404 OCT U H31  1 
HETATM 4307 H H32  . OCT F  4 .   ? 113.492 149.341 114.316 1.00 20.00  ? 404 OCT U H32  1 
HETATM 4308 H H41  . OCT F  4 .   ? 110.811 148.317 114.809 1.00 20.00  ? 404 OCT U H41  1 
HETATM 4309 H H42  . OCT F  4 .   ? 110.801 150.010 114.312 1.00 20.00  ? 404 OCT U H42  1 
HETATM 4310 H H51  . OCT F  4 .   ? 110.762 148.049 112.541 1.00 20.00  ? 404 OCT U H51  1 
HETATM 4311 H H52  . OCT F  4 .   ? 112.505 148.095 112.792 1.00 20.00  ? 404 OCT U H52  1 
HETATM 4312 H H61  . OCT F  4 .   ? 110.749 150.388 111.915 1.00 20.00  ? 404 OCT U H61  1 
HETATM 4313 H H62  . OCT F  4 .   ? 112.474 150.519 112.273 1.00 20.00  ? 404 OCT U H62  1 
HETATM 4314 H H71  . OCT F  4 .   ? 113.094 149.338 110.405 1.00 20.00  ? 404 OCT U H71  1 
HETATM 4315 H H72  . OCT F  4 .   ? 111.589 148.421 110.354 1.00 20.00  ? 404 OCT U H72  1 
HETATM 4316 H H81  . OCT F  4 .   ? 111.514 149.881 108.489 1.00 20.00  ? 404 OCT U H81  1 
HETATM 4317 H H82  . OCT F  4 .   ? 110.448 150.606 109.700 1.00 20.00  ? 404 OCT U H82  1 
HETATM 4318 H H83  . OCT F  4 .   ? 112.073 151.258 109.449 1.00 20.00  ? 404 OCT U H83  1 
HETATM 4319 C C27  . R16 G  5 .   ? 129.490 151.219 108.369 1.00 20.00  ? 405 R16 U C27  1 
HETATM 4320 C C28  . R16 G  5 .   ? 130.229 149.897 108.361 1.00 20.00  ? 405 R16 U C28  1 
HETATM 4321 C C29  . R16 G  5 .   ? 130.746 149.575 109.750 1.00 20.00  ? 405 R16 U C29  1 
HETATM 4322 C C30  . R16 G  5 .   ? 131.276 148.159 109.827 1.00 20.00  ? 405 R16 U C30  1 
HETATM 4323 C C31  . R16 G  5 .   ? 130.419 147.278 110.735 1.00 20.00  ? 405 R16 U C31  1 
HETATM 4324 C C32  . R16 G  5 .   ? 130.869 147.353 112.194 1.00 20.00  ? 405 R16 U C32  1 
HETATM 4325 C C33  . R16 G  5 .   ? 129.775 146.891 113.154 1.00 20.00  ? 405 R16 U C33  1 
HETATM 4326 C C34  . R16 G  5 .   ? 130.304 146.799 114.583 1.00 20.00  ? 405 R16 U C34  1 
HETATM 4327 C C35  . R16 G  5 .   ? 130.884 145.417 114.870 1.00 20.00  ? 405 R16 U C35  1 
HETATM 4328 C C36  . R16 G  5 .   ? 130.402 144.919 116.221 1.00 20.00  ? 405 R16 U C36  1 
HETATM 4329 C C37  . R16 G  5 .   ? 131.205 145.564 117.334 1.00 20.00  ? 405 R16 U C37  1 
HETATM 4330 C C38  . R16 G  5 .   ? 130.501 145.437 118.662 1.00 20.00  ? 405 R16 U C38  1 
HETATM 4331 C C39  . R16 G  5 .   ? 131.509 145.223 119.741 1.00 20.00  ? 405 R16 U C39  1 
HETATM 4332 C C40  . R16 G  5 .   ? 130.860 145.196 121.067 1.00 20.00  ? 405 R16 U C40  1 
HETATM 4333 C C41  . R16 G  5 .   ? 131.377 146.314 121.895 1.00 20.00  ? 405 R16 U C41  1 
HETATM 4334 C C42  . R16 G  5 .   ? 130.715 146.319 123.233 1.00 20.00  ? 405 R16 U C42  1 
HETATM 4335 H H271 . R16 G  5 .   ? 128.424 151.104 108.601 1.00 20.00  ? 405 R16 U H271 1 
HETATM 4336 H H272 . R16 G  5 .   ? 129.903 151.918 109.106 1.00 20.00  ? 405 R16 U H272 1 
HETATM 4337 H H273 . R16 G  5 .   ? 129.538 151.729 107.398 1.00 20.00  ? 405 R16 U H273 1 
HETATM 4338 H H281 . R16 G  5 .   ? 131.064 149.936 107.637 1.00 20.00  ? 405 R16 U H281 1 
HETATM 4339 H H282 . R16 G  5 .   ? 129.573 149.088 107.988 1.00 20.00  ? 405 R16 U H282 1 
HETATM 4340 H H291 . R16 G  5 .   ? 131.539 150.299 110.030 1.00 20.00  ? 405 R16 U H291 1 
HETATM 4341 H H292 . R16 G  5 .   ? 129.949 149.738 110.498 1.00 20.00  ? 405 R16 U H292 1 
HETATM 4342 H H301 . R16 G  5 .   ? 131.331 147.726 108.809 1.00 20.00  ? 405 R16 U H301 1 
HETATM 4343 H H302 . R16 G  5 .   ? 132.323 148.164 110.188 1.00 20.00  ? 405 R16 U H302 1 
HETATM 4344 H H311 . R16 G  5 .   ? 129.355 147.569 110.654 1.00 20.00  ? 405 R16 U H311 1 
HETATM 4345 H H312 . R16 G  5 .   ? 130.445 146.227 110.379 1.00 20.00  ? 405 R16 U H312 1 
HETATM 4346 H H321 . R16 G  5 .   ? 131.787 146.747 112.337 1.00 20.00  ? 405 R16 U H321 1 
HETATM 4347 H H322 . R16 G  5 .   ? 131.183 148.385 112.447 1.00 20.00  ? 405 R16 U H322 1 
HETATM 4348 H H331 . R16 G  5 .   ? 128.912 147.584 113.103 1.00 20.00  ? 405 R16 U H331 1 
HETATM 4349 H H332 . R16 G  5 .   ? 129.366 145.914 112.830 1.00 20.00  ? 405 R16 U H332 1 
HETATM 4350 H H341 . R16 G  5 .   ? 129.499 147.038 115.304 1.00 20.00  ? 405 R16 U H341 1 
HETATM 4351 H H342 . R16 G  5 .   ? 131.074 147.577 114.757 1.00 20.00  ? 405 R16 U H342 1 
HETATM 4352 H H351 . R16 G  5 .   ? 131.990 145.451 114.847 1.00 20.00  ? 405 R16 U H351 1 
HETATM 4353 H H352 . R16 G  5 .   ? 130.608 144.704 114.068 1.00 20.00  ? 405 R16 U H352 1 
HETATM 4354 H H361 . R16 G  5 .   ? 130.486 143.817 116.278 1.00 20.00  ? 405 R16 U H361 1 
HETATM 4355 H H362 . R16 G  5 .   ? 129.324 145.129 116.354 1.00 20.00  ? 405 R16 U H362 1 
HETATM 4356 H H371 . R16 G  5 .   ? 131.398 146.629 117.111 1.00 20.00  ? 405 R16 U H371 1 
HETATM 4357 H H372 . R16 G  5 .   ? 132.211 145.109 117.392 1.00 20.00  ? 405 R16 U H372 1 
HETATM 4358 H H381 . R16 G  5 .   ? 129.772 144.605 118.640 1.00 20.00  ? 405 R16 U H381 1 
HETATM 4359 H H382 . R16 G  5 .   ? 129.895 146.339 118.869 1.00 20.00  ? 405 R16 U H382 1 
HETATM 4360 H H391 . R16 G  5 .   ? 132.062 144.282 119.566 1.00 20.00  ? 405 R16 U H391 1 
HETATM 4361 H H392 . R16 G  5 .   ? 132.278 146.017 119.709 1.00 20.00  ? 405 R16 U H392 1 
HETATM 4362 H H401 . R16 G  5 .   ? 131.033 144.228 121.574 1.00 20.00  ? 405 R16 U H401 1 
HETATM 4363 H H402 . R16 G  5 .   ? 129.760 145.274 120.967 1.00 20.00  ? 405 R16 U H402 1 
HETATM 4364 H H411 . R16 G  5 .   ? 131.222 147.283 121.381 1.00 20.00  ? 405 R16 U H411 1 
HETATM 4365 H H412 . R16 G  5 .   ? 132.473 146.216 122.008 1.00 20.00  ? 405 R16 U H412 1 
HETATM 4366 H H421 . R16 G  5 .   ? 131.401 146.011 124.031 1.00 20.00  ? 405 R16 U H421 1 
HETATM 4367 H H422 . R16 G  5 .   ? 130.344 147.310 123.521 1.00 20.00  ? 405 R16 U H422 1 
HETATM 4368 H H423 . R16 G  5 .   ? 129.862 145.629 123.280 1.00 20.00  ? 405 R16 U H423 1 
HETATM 4369 C C1   . OCT H  4 .   ? 128.435 150.895 122.395 1.00 20.00  ? 406 OCT U C1   1 
HETATM 4370 C C2   . OCT H  4 .   ? 128.214 151.907 121.279 1.00 20.00  ? 406 OCT U C2   1 
HETATM 4371 C C3   . OCT H  4 .   ? 128.646 151.373 119.923 1.00 20.00  ? 406 OCT U C3   1 
HETATM 4372 C C4   . OCT H  4 .   ? 127.720 151.848 118.814 1.00 20.00  ? 406 OCT U C4   1 
HETATM 4373 C C5   . OCT H  4 .   ? 128.210 151.406 117.445 1.00 20.00  ? 406 OCT U C5   1 
HETATM 4374 C C6   . OCT H  4 .   ? 127.736 152.346 116.352 1.00 20.00  ? 406 OCT U C6   1 
HETATM 4375 C C7   . OCT H  4 .   ? 128.649 152.305 115.139 1.00 20.00  ? 406 OCT U C7   1 
HETATM 4376 C C8   . OCT H  4 .   ? 128.198 153.303 114.084 1.00 20.00  ? 406 OCT U C8   1 
HETATM 4377 H H11  . OCT H  4 .   ? 127.663 150.137 122.349 1.00 20.00  ? 406 OCT U H11  1 
HETATM 4378 H H12  . OCT H  4 .   ? 129.405 150.432 122.267 1.00 20.00  ? 406 OCT U H12  1 
HETATM 4379 H H13  . OCT H  4 .   ? 128.395 151.399 123.352 1.00 20.00  ? 406 OCT U H13  1 
HETATM 4380 H H21  . OCT H  4 .   ? 128.777 152.804 121.500 1.00 20.00  ? 406 OCT U H21  1 
HETATM 4381 H H22  . OCT H  4 .   ? 127.160 152.154 121.234 1.00 20.00  ? 406 OCT U H22  1 
HETATM 4382 H H31  . OCT H  4 .   ? 129.652 151.713 119.712 1.00 20.00  ? 406 OCT U H31  1 
HETATM 4383 H H32  . OCT H  4 .   ? 128.636 150.291 119.951 1.00 20.00  ? 406 OCT U H32  1 
HETATM 4384 H H41  . OCT H  4 .   ? 126.732 151.442 118.982 1.00 20.00  ? 406 OCT U H41  1 
HETATM 4385 H H42  . OCT H  4 .   ? 127.669 152.929 118.841 1.00 20.00  ? 406 OCT U H42  1 
HETATM 4386 H H51  . OCT H  4 .   ? 127.838 150.411 117.241 1.00 20.00  ? 406 OCT U H51  1 
HETATM 4387 H H52  . OCT H  4 .   ? 129.292 151.388 117.448 1.00 20.00  ? 406 OCT U H52  1 
HETATM 4388 H H61  . OCT H  4 .   ? 126.736 152.060 116.050 1.00 20.00  ? 406 OCT U H61  1 
HETATM 4389 H H62  . OCT H  4 .   ? 127.714 153.357 116.738 1.00 20.00  ? 406 OCT U H62  1 
HETATM 4390 H H71  . OCT H  4 .   ? 129.657 152.544 115.449 1.00 20.00  ? 406 OCT U H71  1 
HETATM 4391 H H72  . OCT H  4 .   ? 128.631 151.308 114.719 1.00 20.00  ? 406 OCT U H72  1 
HETATM 4392 H H81  . OCT H  4 .   ? 128.401 152.903 113.098 1.00 20.00  ? 406 OCT U H81  1 
HETATM 4393 H H82  . OCT H  4 .   ? 127.135 153.481 114.192 1.00 20.00  ? 406 OCT U H82  1 
HETATM 4394 H H83  . OCT H  4 .   ? 128.736 154.233 114.216 1.00 20.00  ? 406 OCT U H83  1 
HETATM 4395 C C1   . OCT I  4 .   ? 99.341  115.934 118.723 1.00 20.00  ? 407 OCT U C1   1 
HETATM 4396 C C2   . OCT I  4 .   ? 98.797  114.899 117.744 1.00 20.00  ? 407 OCT U C2   1 
HETATM 4397 C C3   . OCT I  4 .   ? 98.627  115.461 116.339 1.00 20.00  ? 407 OCT U C3   1 
HETATM 4398 C C4   . OCT I  4 .   ? 98.666  114.370 115.278 1.00 20.00  ? 407 OCT U C4   1 
HETATM 4399 C C5   . OCT I  4 .   ? 97.906  114.769 114.024 1.00 20.00  ? 407 OCT U C5   1 
HETATM 4400 C C6   . OCT I  4 .   ? 98.594  114.301 112.751 1.00 20.00  ? 407 OCT U C6   1 
HETATM 4401 C C7   . OCT I  4 .   ? 98.193  115.154 111.558 1.00 20.00  ? 407 OCT U C7   1 
HETATM 4402 C C8   . OCT I  4 .   ? 97.840  114.314 110.340 1.00 20.00  ? 407 OCT U C8   1 
HETATM 4403 H H11  . OCT I  4 .   ? 98.860  116.886 118.538 1.00 20.00  ? 407 OCT U H11  1 
HETATM 4404 H H12  . OCT I  4 .   ? 99.140  115.614 119.737 1.00 20.00  ? 407 OCT U H12  1 
HETATM 4405 H H13  . OCT I  4 .   ? 100.410 116.036 118.578 1.00 20.00  ? 407 OCT U H13  1 
HETATM 4406 H H21  . OCT I  4 .   ? 97.836  114.551 118.101 1.00 20.00  ? 407 OCT U H21  1 
HETATM 4407 H H22  . OCT I  4 .   ? 99.482  114.061 117.702 1.00 20.00  ? 407 OCT U H22  1 
HETATM 4408 H H31  . OCT I  4 .   ? 97.676  115.975 116.278 1.00 20.00  ? 407 OCT U H31  1 
HETATM 4409 H H32  . OCT I  4 .   ? 99.423  116.168 116.146 1.00 20.00  ? 407 OCT U H32  1 
HETATM 4410 H H41  . OCT I  4 .   ? 99.697  114.170 115.020 1.00 20.00  ? 407 OCT U H41  1 
HETATM 4411 H H42  . OCT I  4 .   ? 98.223  113.471 115.687 1.00 20.00  ? 407 OCT U H42  1 
HETATM 4412 H H51  . OCT I  4 .   ? 97.823  115.848 113.998 1.00 20.00  ? 407 OCT U H51  1 
HETATM 4413 H H52  . OCT I  4 .   ? 96.914  114.341 114.062 1.00 20.00  ? 407 OCT U H52  1 
HETATM 4414 H H61  . OCT I  4 .   ? 99.666  114.362 112.883 1.00 20.00  ? 407 OCT U H61  1 
HETATM 4415 H H62  . OCT I  4 .   ? 98.317  113.273 112.556 1.00 20.00  ? 407 OCT U H62  1 
HETATM 4416 H H71  . OCT I  4 .   ? 97.332  115.751 111.830 1.00 20.00  ? 407 OCT U H71  1 
HETATM 4417 H H72  . OCT I  4 .   ? 99.013  115.812 111.304 1.00 20.00  ? 407 OCT U H72  1 
HETATM 4418 H H81  . OCT I  4 .   ? 96.958  113.724 110.555 1.00 20.00  ? 407 OCT U H81  1 
HETATM 4419 H H82  . OCT I  4 .   ? 97.646  114.964 109.497 1.00 20.00  ? 407 OCT U H82  1 
HETATM 4420 H H83  . OCT I  4 .   ? 98.668  113.655 110.109 1.00 20.00  ? 407 OCT U H83  1 
HETATM 4421 C C1   . OCT J  4 .   ? 101.745 130.451 117.141 1.00 20.00  ? 408 OCT U C1   1 
HETATM 4422 C C2   . OCT J  4 .   ? 101.417 131.034 115.770 1.00 20.00  ? 408 OCT U C2   1 
HETATM 4423 C C3   . OCT J  4 .   ? 100.593 130.080 114.918 1.00 20.00  ? 408 OCT U C3   1 
HETATM 4424 C C4   . OCT J  4 .   ? 99.832  130.783 113.804 1.00 20.00  ? 408 OCT U C4   1 
HETATM 4425 C C5   . OCT J  4 .   ? 100.510 130.609 112.457 1.00 20.00  ? 408 OCT U C5   1 
HETATM 4426 C C6   . OCT J  4 .   ? 99.655  131.148 111.325 1.00 20.00  ? 408 OCT U C6   1 
HETATM 4427 C C7   . OCT J  4 .   ? 100.363 131.045 109.988 1.00 20.00  ? 408 OCT U C7   1 
HETATM 4428 C C8   . OCT J  4 .   ? 99.382  131.014 108.826 1.00 20.00  ? 408 OCT U C8   1 
HETATM 4429 H H11  . OCT J  4 .   ? 100.836 130.377 117.724 1.00 20.00  ? 408 OCT U H11  1 
HETATM 4430 H H12  . OCT J  4 .   ? 102.176 129.467 117.015 1.00 20.00  ? 408 OCT U H12  1 
HETATM 4431 H H13  . OCT J  4 .   ? 102.451 131.096 117.648 1.00 20.00  ? 408 OCT U H13  1 
HETATM 4432 H H21  . OCT J  4 .   ? 102.342 131.254 115.252 1.00 20.00  ? 408 OCT U H21  1 
HETATM 4433 H H22  . OCT J  4 .   ? 100.861 131.952 115.907 1.00 20.00  ? 408 OCT U H22  1 
HETATM 4434 H H31  . OCT J  4 .   ? 101.256 129.348 114.476 1.00 20.00  ? 408 OCT U H31  1 
HETATM 4435 H H32  . OCT J  4 .   ? 99.884  129.571 115.558 1.00 20.00  ? 408 OCT U H32  1 
HETATM 4436 H H41  . OCT J  4 .   ? 98.833  130.374 113.746 1.00 20.00  ? 408 OCT U H41  1 
HETATM 4437 H H42  . OCT J  4 .   ? 99.771  131.840 114.030 1.00 20.00  ? 408 OCT U H42  1 
HETATM 4438 H H51  . OCT J  4 .   ? 100.694 129.556 112.287 1.00 20.00  ? 408 OCT U H51  1 
HETATM 4439 H H52  . OCT J  4 .   ? 101.455 131.138 112.467 1.00 20.00  ? 408 OCT U H52  1 
HETATM 4440 H H61  . OCT J  4 .   ? 98.733  130.581 111.280 1.00 20.00  ? 408 OCT U H61  1 
HETATM 4441 H H62  . OCT J  4 .   ? 99.424  132.187 111.524 1.00 20.00  ? 408 OCT U H62  1 
HETATM 4442 H H71  . OCT J  4 .   ? 101.021 131.896 109.873 1.00 20.00  ? 408 OCT U H71  1 
HETATM 4443 H H72  . OCT J  4 .   ? 100.954 130.137 109.976 1.00 20.00  ? 408 OCT U H72  1 
HETATM 4444 H H81  . OCT J  4 .   ? 99.926  131.070 107.892 1.00 20.00  ? 408 OCT U H81  1 
HETATM 4445 H H82  . OCT J  4 .   ? 98.814  130.093 108.862 1.00 20.00  ? 408 OCT U H82  1 
HETATM 4446 H H83  . OCT J  4 .   ? 98.709  131.859 108.906 1.00 20.00  ? 408 OCT U H83  1 
HETATM 4447 C C1   . OCT K  4 .   ? 103.696 106.423 121.895 1.00 20.00  ? 409 OCT U C1   1 
HETATM 4448 C C2   . OCT K  4 .   ? 104.732 105.636 121.106 1.00 20.00  ? 409 OCT U C2   1 
HETATM 4449 C C3   . OCT K  4 .   ? 104.227 105.213 119.733 1.00 20.00  ? 409 OCT U C3   1 
HETATM 4450 C C4   . OCT K  4 .   ? 104.965 103.981 119.233 1.00 20.00  ? 409 OCT U C4   1 
HETATM 4451 C C5   . OCT K  4 .   ? 105.733 104.232 117.946 1.00 20.00  ? 409 OCT U C5   1 
HETATM 4452 C C6   . OCT K  4 .   ? 104.879 104.029 116.705 1.00 20.00  ? 409 OCT U C6   1 
HETATM 4453 C C7   . OCT K  4 .   ? 105.612 103.190 115.666 1.00 20.00  ? 409 OCT U C7   1 
HETATM 4454 C C8   . OCT K  4 .   ? 104.852 103.117 114.345 1.00 20.00  ? 409 OCT U C8   1 
HETATM 4455 H H11  . OCT K  4 .   ? 104.169 106.881 122.755 1.00 20.00  ? 409 OCT U H11  1 
HETATM 4456 H H12  . OCT K  4 .   ? 103.273 107.192 121.260 1.00 20.00  ? 409 OCT U H12  1 
HETATM 4457 H H13  . OCT K  4 .   ? 102.912 105.753 122.224 1.00 20.00  ? 409 OCT U H13  1 
HETATM 4458 H H21  . OCT K  4 .   ? 104.997 104.751 121.671 1.00 20.00  ? 409 OCT U H21  1 
HETATM 4459 H H22  . OCT K  4 .   ? 105.616 106.249 120.978 1.00 20.00  ? 409 OCT U H22  1 
HETATM 4460 H H31  . OCT K  4 .   ? 103.170 104.991 119.800 1.00 20.00  ? 409 OCT U H31  1 
HETATM 4461 H H32  . OCT K  4 .   ? 104.377 106.026 119.034 1.00 20.00  ? 409 OCT U H32  1 
HETATM 4462 H H41  . OCT K  4 .   ? 105.667 103.663 119.993 1.00 20.00  ? 409 OCT U H41  1 
HETATM 4463 H H42  . OCT K  4 .   ? 104.249 103.187 119.065 1.00 20.00  ? 409 OCT U H42  1 
HETATM 4464 H H51  . OCT K  4 .   ? 106.574 103.552 117.902 1.00 20.00  ? 409 OCT U H51  1 
HETATM 4465 H H52  . OCT K  4 .   ? 106.104 105.250 117.953 1.00 20.00  ? 409 OCT U H52  1 
HETATM 4466 H H61  . OCT K  4 .   ? 103.962 103.527 116.981 1.00 20.00  ? 409 OCT U H61  1 
HETATM 4467 H H62  . OCT K  4 .   ? 104.643 104.994 116.276 1.00 20.00  ? 409 OCT U H62  1 
HETATM 4468 H H71  . OCT K  4 .   ? 106.586 103.627 115.488 1.00 20.00  ? 409 OCT U H71  1 
HETATM 4469 H H72  . OCT K  4 .   ? 105.740 102.188 116.053 1.00 20.00  ? 409 OCT U H72  1 
HETATM 4470 H H81  . OCT K  4 .   ? 105.416 102.523 113.637 1.00 20.00  ? 409 OCT U H81  1 
HETATM 4471 H H82  . OCT K  4 .   ? 103.885 102.661 114.514 1.00 20.00  ? 409 OCT U H82  1 
HETATM 4472 H H83  . OCT K  4 .   ? 104.717 104.117 113.955 1.00 20.00  ? 409 OCT U H83  1 
HETATM 4473 C C1   . D12 L  3 .   ? 126.342 148.149 138.210 1.00 20.00  ? 410 D12 U C1   1 
HETATM 4474 C C2   . D12 L  3 .   ? 125.968 147.835 136.760 1.00 20.00  ? 410 D12 U C2   1 
HETATM 4475 C C3   . D12 L  3 .   ? 126.176 146.368 136.388 1.00 20.00  ? 410 D12 U C3   1 
HETATM 4476 C C4   . D12 L  3 .   ? 125.787 146.077 134.938 1.00 20.00  ? 410 D12 U C4   1 
HETATM 4477 C C5   . D12 L  3 .   ? 126.844 145.249 134.208 1.00 20.00  ? 410 D12 U C5   1 
HETATM 4478 C C6   . D12 L  3 .   ? 126.678 145.258 132.687 1.00 20.00  ? 410 D12 U C6   1 
HETATM 4479 C C7   . D12 L  3 .   ? 127.008 143.903 132.085 1.00 20.00  ? 410 D12 U C7   1 
HETATM 4480 C C8   . D12 L  3 .   ? 126.754 143.878 130.587 1.00 20.00  ? 410 D12 U C8   1 
HETATM 4481 C C9   . D12 L  3 .   ? 125.270 143.847 130.256 1.00 20.00  ? 410 D12 U C9   1 
HETATM 4482 C C10  . D12 L  3 .   ? 124.943 142.878 129.127 1.00 20.00  ? 410 D12 U C10  1 
HETATM 4483 C C11  . D12 L  3 .   ? 124.666 141.462 129.613 1.00 20.00  ? 410 D12 U C11  1 
HETATM 4484 C C12  . D12 L  3 .   ? 123.374 140.890 129.038 1.00 20.00  ? 410 D12 U C12  1 
HETATM 4485 H H11  . D12 L  3 .   ? 127.229 147.584 138.481 1.00 20.00  ? 410 D12 U H11  1 
HETATM 4486 H H12  . D12 L  3 .   ? 125.520 147.867 138.862 1.00 20.00  ? 410 D12 U H12  1 
HETATM 4487 H H13  . D12 L  3 .   ? 126.540 149.212 138.311 1.00 20.00  ? 410 D12 U H13  1 
HETATM 4488 H H21  . D12 L  3 .   ? 126.577 148.448 136.104 1.00 20.00  ? 410 D12 U H21  1 
HETATM 4489 H H22  . D12 L  3 .   ? 124.925 148.087 136.606 1.00 20.00  ? 410 D12 U H22  1 
HETATM 4490 H H31  . D12 L  3 .   ? 125.573 145.751 137.045 1.00 20.00  ? 410 D12 U H31  1 
HETATM 4491 H H32  . D12 L  3 .   ? 127.222 146.116 136.528 1.00 20.00  ? 410 D12 U H32  1 
HETATM 4492 H H41  . D12 L  3 .   ? 125.656 147.018 134.416 1.00 20.00  ? 410 D12 U H41  1 
HETATM 4493 H H42  . D12 L  3 .   ? 124.847 145.534 134.930 1.00 20.00  ? 410 D12 U H42  1 
HETATM 4494 H H51  . D12 L  3 .   ? 127.824 145.642 134.453 1.00 20.00  ? 410 D12 U H51  1 
HETATM 4495 H H52  . D12 L  3 .   ? 126.782 144.224 134.557 1.00 20.00  ? 410 D12 U H52  1 
HETATM 4496 H H61  . D12 L  3 .   ? 125.651 145.512 132.446 1.00 20.00  ? 410 D12 U H61  1 
HETATM 4497 H H62  . D12 L  3 .   ? 127.340 146.004 132.262 1.00 20.00  ? 410 D12 U H62  1 
HETATM 4498 H H71  . D12 L  3 .   ? 128.054 143.682 132.270 1.00 20.00  ? 410 D12 U H71  1 
HETATM 4499 H H72  . D12 L  3 .   ? 126.396 143.145 132.563 1.00 20.00  ? 410 D12 U H72  1 
HETATM 4500 H H81  . D12 L  3 .   ? 127.227 142.997 130.166 1.00 20.00  ? 410 D12 U H81  1 
HETATM 4501 H H82  . D12 L  3 .   ? 127.195 144.764 130.143 1.00 20.00  ? 410 D12 U H82  1 
HETATM 4502 H H91  . D12 L  3 .   ? 124.958 144.843 129.962 1.00 20.00  ? 410 D12 U H91  1 
HETATM 4503 H H92  . D12 L  3 .   ? 124.719 143.557 131.144 1.00 20.00  ? 410 D12 U H92  1 
HETATM 4504 H H101 . D12 L  3 .   ? 124.068 143.240 128.599 1.00 20.00  ? 410 D12 U H101 1 
HETATM 4505 H H102 . D12 L  3 .   ? 125.781 142.850 128.438 1.00 20.00  ? 410 D12 U H102 1 
HETATM 4506 H H111 . D12 L  3 .   ? 124.597 141.464 130.695 1.00 20.00  ? 410 D12 U H111 1 
HETATM 4507 H H112 . D12 L  3 .   ? 125.491 140.824 129.316 1.00 20.00  ? 410 D12 U H112 1 
HETATM 4508 H H121 . D12 L  3 .   ? 123.225 139.884 129.419 1.00 20.00  ? 410 D12 U H121 1 
HETATM 4509 H H122 . D12 L  3 .   ? 122.539 141.518 129.333 1.00 20.00  ? 410 D12 U H122 1 
HETATM 4510 H H123 . D12 L  3 .   ? 123.444 140.862 127.955 1.00 20.00  ? 410 D12 U H123 1 
HETATM 4511 C C1   . D12 M  3 .   ? 99.139  109.009 112.518 1.00 20.00  ? 411 D12 U C1   1 
HETATM 4512 C C2   . D12 M  3 .   ? 99.781  109.612 113.757 1.00 20.00  ? 411 D12 U C2   1 
HETATM 4513 C C3   . D12 M  3 .   ? 100.226 108.529 114.722 1.00 20.00  ? 411 D12 U C3   1 
HETATM 4514 C C4   . D12 M  3 .   ? 100.989 109.096 115.908 1.00 20.00  ? 411 D12 U C4   1 
HETATM 4515 C C5   . D12 M  3 .   ? 100.068 109.571 117.019 1.00 20.00  ? 411 D12 U C5   1 
HETATM 4516 C C6   . D12 M  3 .   ? 100.592 109.182 118.391 1.00 20.00  ? 411 D12 U C6   1 
HETATM 4517 C C7   . D12 M  3 .   ? 101.704 110.108 118.865 1.00 20.00  ? 411 D12 U C7   1 
HETATM 4518 C C8   . D12 M  3 .   ? 101.284 110.990 120.036 1.00 20.00  ? 411 D12 U C8   1 
HETATM 4519 C C9   . D12 M  3 .   ? 102.423 111.270 121.009 1.00 20.00  ? 411 D12 U C9   1 
HETATM 4520 C C10  . D12 M  3 .   ? 102.776 112.746 121.106 1.00 20.00  ? 411 D12 U C10  1 
HETATM 4521 C C11  . D12 M  3 .   ? 104.030 112.957 121.936 1.00 20.00  ? 411 D12 U C11  1 
HETATM 4522 C C12  . D12 M  3 .   ? 105.035 113.825 121.204 1.00 20.00  ? 411 D12 U C12  1 
HETATM 4523 H H11  . D12 M  3 .   ? 99.610  108.055 112.300 1.00 20.00  ? 411 D12 U H11  1 
HETATM 4524 H H12  . D12 M  3 .   ? 99.271  109.684 111.678 1.00 20.00  ? 411 D12 U H12  1 
HETATM 4525 H H13  . D12 M  3 .   ? 98.079  108.858 112.700 1.00 20.00  ? 411 D12 U H13  1 
HETATM 4526 H H21  . D12 M  3 .   ? 99.066  110.260 114.253 1.00 20.00  ? 411 D12 U H21  1 
HETATM 4527 H H22  . D12 M  3 .   ? 100.645 110.195 113.460 1.00 20.00  ? 411 D12 U H22  1 
HETATM 4528 H H31  . D12 M  3 .   ? 100.868 107.835 114.193 1.00 20.00  ? 411 D12 U H31  1 
HETATM 4529 H H32  . D12 M  3 .   ? 99.352  108.000 115.081 1.00 20.00  ? 411 D12 U H32  1 
HETATM 4530 H H41  . D12 M  3 .   ? 101.588 109.935 115.570 1.00 20.00  ? 411 D12 U H41  1 
HETATM 4531 H H42  . D12 M  3 .   ? 101.650 108.330 116.299 1.00 20.00  ? 411 D12 U H42  1 
HETATM 4532 H H51  . D12 M  3 .   ? 99.986  110.651 116.968 1.00 20.00  ? 411 D12 U H51  1 
HETATM 4533 H H52  . D12 M  3 .   ? 99.085  109.135 116.879 1.00 20.00  ? 411 D12 U H52  1 
HETATM 4534 H H61  . D12 M  3 .   ? 99.773  109.218 119.099 1.00 20.00  ? 411 D12 U H61  1 
HETATM 4535 H H62  . D12 M  3 .   ? 100.975 108.169 118.347 1.00 20.00  ? 411 D12 U H62  1 
HETATM 4536 H H71  . D12 M  3 .   ? 102.552 109.501 119.166 1.00 20.00  ? 411 D12 U H71  1 
HETATM 4537 H H72  . D12 M  3 .   ? 102.007 110.744 118.041 1.00 20.00  ? 411 D12 U H72  1 
HETATM 4538 H H81  . D12 M  3 .   ? 100.479 110.506 120.576 1.00 20.00  ? 411 D12 U H81  1 
HETATM 4539 H H82  . D12 M  3 .   ? 100.926 111.936 119.645 1.00 20.00  ? 411 D12 U H82  1 
HETATM 4540 H H91  . D12 M  3 .   ? 103.306 110.728 120.683 1.00 20.00  ? 411 D12 U H91  1 
HETATM 4541 H H92  . D12 M  3 .   ? 102.139 110.917 121.993 1.00 20.00  ? 411 D12 U H92  1 
HETATM 4542 H H101 . D12 M  3 .   ? 102.943 113.135 120.107 1.00 20.00  ? 411 D12 U H101 1 
HETATM 4543 H H102 . D12 M  3 .   ? 101.949 113.278 121.563 1.00 20.00  ? 411 D12 U H102 1 
HETATM 4544 H H111 . D12 M  3 .   ? 104.481 111.993 122.143 1.00 20.00  ? 411 D12 U H111 1 
HETATM 4545 H H112 . D12 M  3 .   ? 103.763 113.436 122.872 1.00 20.00  ? 411 D12 U H112 1 
HETATM 4546 H H121 . D12 M  3 .   ? 105.430 113.277 120.354 1.00 20.00  ? 411 D12 U H121 1 
HETATM 4547 H H122 . D12 M  3 .   ? 104.544 114.729 120.857 1.00 20.00  ? 411 D12 U H122 1 
HETATM 4548 H H123 . D12 M  3 .   ? 105.847 114.085 121.877 1.00 20.00  ? 411 D12 U H123 1 
HETATM 4549 C C1   . OCT N  4 .   ? 147.676 126.301 118.878 1.00 20.00  ? 412 OCT U C1   1 
HETATM 4550 C C2   . OCT N  4 .   ? 147.598 125.674 117.493 1.00 20.00  ? 412 OCT U C2   1 
HETATM 4551 C C3   . OCT N  4 .   ? 148.656 126.249 116.568 1.00 20.00  ? 412 OCT U C3   1 
HETATM 4552 C C4   . OCT N  4 .   ? 148.095 127.314 115.643 1.00 20.00  ? 412 OCT U C4   1 
HETATM 4553 C C5   . OCT N  4 .   ? 148.040 126.813 114.215 1.00 20.00  ? 412 OCT U C5   1 
HETATM 4554 C C6   . OCT N  4 .   ? 149.289 127.188 113.440 1.00 20.00  ? 412 OCT U C6   1 
HETATM 4555 C C7   . OCT N  4 .   ? 149.581 126.162 112.362 1.00 20.00  ? 412 OCT U C7   1 
HETATM 4556 C C8   . OCT N  4 .   ? 149.919 126.818 111.035 1.00 20.00  ? 412 OCT U C8   1 
HETATM 4557 H H11  . OCT N  4 .   ? 146.870 125.920 119.493 1.00 20.00  ? 412 OCT U H11  1 
HETATM 4558 H H12  . OCT N  4 .   ? 148.627 126.055 119.331 1.00 20.00  ? 412 OCT U H12  1 
HETATM 4559 H H13  . OCT N  4 .   ? 147.586 127.377 118.788 1.00 20.00  ? 412 OCT U H13  1 
HETATM 4560 H H21  . OCT N  4 .   ? 146.618 125.858 117.075 1.00 20.00  ? 412 OCT U H21  1 
HETATM 4561 H H22  . OCT N  4 .   ? 147.751 124.606 117.583 1.00 20.00  ? 412 OCT U H22  1 
HETATM 4562 H H31  . OCT N  4 .   ? 149.441 126.689 117.170 1.00 20.00  ? 412 OCT U H31  1 
HETATM 4563 H H32  . OCT N  4 .   ? 149.079 125.449 115.973 1.00 20.00  ? 412 OCT U H32  1 
HETATM 4564 H H41  . OCT N  4 .   ? 147.099 127.584 115.967 1.00 20.00  ? 412 OCT U H41  1 
HETATM 4565 H H42  . OCT N  4 .   ? 148.732 128.187 115.684 1.00 20.00  ? 412 OCT U H42  1 
HETATM 4566 H H51  . OCT N  4 .   ? 147.179 127.247 113.724 1.00 20.00  ? 412 OCT U H51  1 
HETATM 4567 H H52  . OCT N  4 .   ? 147.937 125.735 114.223 1.00 20.00  ? 412 OCT U H52  1 
HETATM 4568 H H61  . OCT N  4 .   ? 149.144 128.156 112.979 1.00 20.00  ? 412 OCT U H61  1 
HETATM 4569 H H62  . OCT N  4 .   ? 150.128 127.237 114.123 1.00 20.00  ? 412 OCT U H62  1 
HETATM 4570 H H71  . OCT N  4 .   ? 150.415 125.547 112.675 1.00 20.00  ? 412 OCT U H71  1 
HETATM 4571 H H72  . OCT N  4 .   ? 148.708 125.534 112.228 1.00 20.00  ? 412 OCT U H72  1 
HETATM 4572 H H81  . OCT N  4 .   ? 150.239 126.062 110.329 1.00 20.00  ? 412 OCT U H81  1 
HETATM 4573 H H82  . OCT N  4 .   ? 149.043 127.325 110.652 1.00 20.00  ? 412 OCT U H82  1 
HETATM 4574 H H83  . OCT N  4 .   ? 150.715 127.536 111.185 1.00 20.00  ? 412 OCT U H83  1 
HETATM 4575 C C1   . EIC O  6 .   ? 127.410 140.944 113.148 1.00 20.00  ? 413 EIC U C1   1 
HETATM 4576 C C2   . EIC O  6 .   ? 127.571 140.406 114.565 1.00 20.00  ? 413 EIC U C2   1 
HETATM 4577 C C3   . EIC O  6 .   ? 126.591 139.279 114.926 1.00 20.00  ? 413 EIC U C3   1 
HETATM 4578 C C4   . EIC O  6 .   ? 127.135 138.422 116.066 1.00 20.00  ? 413 EIC U C4   1 
HETATM 4579 C C5   . EIC O  6 .   ? 126.033 137.521 116.612 1.00 20.00  ? 413 EIC U C5   1 
HETATM 4580 C C6   . EIC O  6 .   ? 126.619 136.561 117.650 1.00 20.00  ? 413 EIC U C6   1 
HETATM 4581 C C7   . EIC O  6 .   ? 125.799 136.469 118.947 1.00 20.00  ? 413 EIC U C7   1 
HETATM 4582 C C8   . EIC O  6 .   ? 126.659 136.718 120.192 1.00 20.00  ? 413 EIC U C8   1 
HETATM 4583 C C9   . EIC O  6 .   ? 126.321 135.715 121.263 1.00 20.00  ? 413 EIC U C9   1 
HETATM 4584 C C10  . EIC O  6 .   ? 127.002 135.440 122.375 1.00 20.00  ? 413 EIC U C10  1 
HETATM 4585 C C11  . EIC O  6 .   ? 128.290 136.044 122.879 1.00 20.00  ? 413 EIC U C11  1 
HETATM 4586 C C12  . EIC O  6 .   ? 128.428 135.734 124.360 1.00 20.00  ? 413 EIC U C12  1 
HETATM 4587 C C13  . EIC O  6 .   ? 128.791 136.538 125.370 1.00 20.00  ? 413 EIC U C13  1 
HETATM 4588 C C14  . EIC O  6 .   ? 129.174 137.996 125.302 1.00 20.00  ? 413 EIC U C14  1 
HETATM 4589 C C15  . EIC O  6 .   ? 128.971 138.691 126.652 1.00 20.00  ? 413 EIC U C15  1 
HETATM 4590 C C16  . EIC O  6 .   ? 129.568 140.104 126.652 1.00 20.00  ? 413 EIC U C16  1 
HETATM 4591 C C17  . EIC O  6 .   ? 128.480 141.178 126.676 1.00 20.00  ? 413 EIC U C17  1 
HETATM 4592 C C18  . EIC O  6 .   ? 129.033 142.567 126.345 1.00 20.00  ? 413 EIC U C18  1 
HETATM 4593 O O1   . EIC O  6 .   ? 128.403 141.291 112.546 1.00 20.00  ? 413 EIC U O1   1 
HETATM 4594 O O2   . EIC O  6 .   ? 126.290 140.991 112.698 1.00 20.00  ? 413 EIC U O2   1 
HETATM 4595 H H21  . EIC O  6 .   ? 127.441 141.243 115.261 1.00 20.00  ? 413 EIC U H21  1 
HETATM 4596 H H22  . EIC O  6 .   ? 128.602 140.045 114.676 1.00 20.00  ? 413 EIC U H22  1 
HETATM 4597 H H31  . EIC O  6 .   ? 126.408 138.654 114.042 1.00 20.00  ? 413 EIC U H31  1 
HETATM 4598 H H32  . EIC O  6 .   ? 125.627 139.715 115.220 1.00 20.00  ? 413 EIC U H32  1 
HETATM 4599 H H41  . EIC O  6 .   ? 127.518 139.073 116.862 1.00 20.00  ? 413 EIC U H41  1 
HETATM 4600 H H42  . EIC O  6 .   ? 127.973 137.812 115.702 1.00 20.00  ? 413 EIC U H42  1 
HETATM 4601 H H51  . EIC O  6 .   ? 125.578 136.961 115.786 1.00 20.00  ? 413 EIC U H51  1 
HETATM 4602 H H52  . EIC O  6 .   ? 125.246 138.135 117.066 1.00 20.00  ? 413 EIC U H52  1 
HETATM 4603 H H61  . EIC O  6 .   ? 127.642 136.888 117.881 1.00 20.00  ? 413 EIC U H61  1 
HETATM 4604 H H62  . EIC O  6 .   ? 126.697 135.560 117.204 1.00 20.00  ? 413 EIC U H62  1 
HETATM 4605 H H71  . EIC O  6 .   ? 125.346 135.470 119.005 1.00 20.00  ? 413 EIC U H71  1 
HETATM 4606 H H72  . EIC O  6 .   ? 124.980 137.200 118.926 1.00 20.00  ? 413 EIC U H72  1 
HETATM 4607 H H81  . EIC O  6 .   ? 126.456 137.725 120.570 1.00 20.00  ? 413 EIC U H81  1 
HETATM 4608 H H82  . EIC O  6 .   ? 127.719 136.692 119.924 1.00 20.00  ? 413 EIC U H82  1 
HETATM 4609 H H91  . EIC O  6 .   ? 125.401 135.167 121.074 1.00 20.00  ? 413 EIC U H91  1 
HETATM 4610 H H1O1 . EIC O  6 .   ? 126.602 134.676 123.043 1.00 20.00  ? 413 EIC U H1O1 1 
HETATM 4611 H H111 . EIC O  6 .   ? 128.311 137.130 122.736 1.00 20.00  ? 413 EIC U H111 1 
HETATM 4612 H H112 . EIC O  6 .   ? 129.118 135.630 122.294 1.00 20.00  ? 413 EIC U H112 1 
HETATM 4613 H H121 . EIC O  6 .   ? 128.184 134.699 124.597 1.00 20.00  ? 413 EIC U H121 1 
HETATM 4614 H H131 . EIC O  6 .   ? 128.829 136.123 126.376 1.00 20.00  ? 413 EIC U H131 1 
HETATM 4615 H H141 . EIC O  6 .   ? 128.598 138.534 124.541 1.00 20.00  ? 413 EIC U H141 1 
HETATM 4616 H H142 . EIC O  6 .   ? 130.228 138.082 125.010 1.00 20.00  ? 413 EIC U H142 1 
HETATM 4617 H H151 . EIC O  6 .   ? 129.433 138.087 127.442 1.00 20.00  ? 413 EIC U H151 1 
HETATM 4618 H H152 . EIC O  6 .   ? 127.896 138.756 126.869 1.00 20.00  ? 413 EIC U H152 1 
HETATM 4619 H H161 . EIC O  6 .   ? 130.184 140.235 125.751 1.00 20.00  ? 413 EIC U H161 1 
HETATM 4620 H H162 . EIC O  6 .   ? 130.229 140.230 127.521 1.00 20.00  ? 413 EIC U H162 1 
HETATM 4621 H H171 . EIC O  6 .   ? 128.011 141.199 127.667 1.00 20.00  ? 413 EIC U H171 1 
HETATM 4622 H H172 . EIC O  6 .   ? 127.697 140.924 125.953 1.00 20.00  ? 413 EIC U H172 1 
HETATM 4623 H H181 . EIC O  6 .   ? 130.125 142.569 126.438 1.00 20.00  ? 413 EIC U H181 1 
HETATM 4624 H H182 . EIC O  6 .   ? 128.774 142.858 125.320 1.00 20.00  ? 413 EIC U H182 1 
HETATM 4625 H H183 . EIC O  6 .   ? 128.630 143.322 127.034 1.00 20.00  ? 413 EIC U H183 1 
HETATM 4626 C C1   . D12 P  3 .   ? 102.031 115.780 138.528 1.00 20.00  ? 414 D12 U C1   1 
HETATM 4627 C C2   . D12 P  3 .   ? 102.357 114.651 137.560 1.00 20.00  ? 414 D12 U C2   1 
HETATM 4628 C C3   . D12 P  3 .   ? 102.956 115.165 136.259 1.00 20.00  ? 414 D12 U C3   1 
HETATM 4629 C C4   . D12 P  3 .   ? 103.541 114.045 135.409 1.00 20.00  ? 414 D12 U C4   1 
HETATM 4630 C C5   . D12 P  3 .   ? 104.122 114.571 134.102 1.00 20.00  ? 414 D12 U C5   1 
HETATM 4631 C C6   . D12 P  3 .   ? 105.564 114.138 133.872 1.00 20.00  ? 414 D12 U C6   1 
HETATM 4632 C C7   . D12 P  3 .   ? 106.377 115.195 133.135 1.00 20.00  ? 414 D12 U C7   1 
HETATM 4633 C C8   . D12 P  3 .   ? 107.490 114.588 132.286 1.00 20.00  ? 414 D12 U C8   1 
HETATM 4634 C C9   . D12 P  3 .   ? 107.240 114.747 130.793 1.00 20.00  ? 414 D12 U C9   1 
HETATM 4635 C C10  . D12 P  3 .   ? 108.068 113.782 129.961 1.00 20.00  ? 414 D12 U C10  1 
HETATM 4636 C C11  . D12 P  3 .   ? 109.224 114.480 129.276 1.00 20.00  ? 414 D12 U C11  1 
HETATM 4637 C C12  . D12 P  3 .   ? 110.188 113.483 128.664 1.00 20.00  ? 414 D12 U C12  1 
HETATM 4638 H H11  . D12 P  3 .   ? 100.955 115.843 138.659 1.00 20.00  ? 414 D12 U H11  1 
HETATM 4639 H H12  . D12 P  3 .   ? 102.406 116.717 138.128 1.00 20.00  ? 414 D12 U H12  1 
HETATM 4640 H H13  . D12 P  3 .   ? 102.501 115.579 139.486 1.00 20.00  ? 414 D12 U H13  1 
HETATM 4641 H H21  . D12 P  3 .   ? 101.449 114.102 137.336 1.00 20.00  ? 414 D12 U H21  1 
HETATM 4642 H H22  . D12 P  3 .   ? 103.070 113.980 138.028 1.00 20.00  ? 414 D12 U H22  1 
HETATM 4643 H H31  . D12 P  3 .   ? 103.746 115.872 136.491 1.00 20.00  ? 414 D12 U H31  1 
HETATM 4644 H H32  . D12 P  3 .   ? 102.185 115.672 135.691 1.00 20.00  ? 414 D12 U H32  1 
HETATM 4645 H H41  . D12 P  3 .   ? 102.757 113.330 135.186 1.00 20.00  ? 414 D12 U H41  1 
HETATM 4646 H H42  . D12 P  3 .   ? 104.322 113.550 135.975 1.00 20.00  ? 414 D12 U H42  1 
HETATM 4647 H H51  . D12 P  3 .   ? 103.514 114.214 133.278 1.00 20.00  ? 414 D12 U H51  1 
HETATM 4648 H H52  . D12 P  3 .   ? 104.087 115.655 134.121 1.00 20.00  ? 414 D12 U H52  1 
HETATM 4649 H H61  . D12 P  3 .   ? 106.034 113.943 134.829 1.00 20.00  ? 414 D12 U H61  1 
HETATM 4650 H H62  . D12 P  3 .   ? 105.565 113.225 133.287 1.00 20.00  ? 414 D12 U H62  1 
HETATM 4651 H H71  . D12 P  3 .   ? 105.713 115.759 132.490 1.00 20.00  ? 414 D12 U H71  1 
HETATM 4652 H H72  . D12 P  3 .   ? 106.818 115.866 133.863 1.00 20.00  ? 414 D12 U H72  1 
HETATM 4653 H H81  . D12 P  3 .   ? 107.571 113.531 132.518 1.00 20.00  ? 414 D12 U H81  1 
HETATM 4654 H H82  . D12 P  3 .   ? 108.427 115.075 132.534 1.00 20.00  ? 414 D12 U H82  1 
HETATM 4655 H H91  . D12 P  3 .   ? 107.489 115.761 130.502 1.00 20.00  ? 414 D12 U H91  1 
HETATM 4656 H H92  . D12 P  3 .   ? 106.188 114.571 130.596 1.00 20.00  ? 414 D12 U H92  1 
HETATM 4657 H H101 . D12 P  3 .   ? 108.459 113.004 130.608 1.00 20.00  ? 414 D12 U H101 1 
HETATM 4658 H H102 . D12 P  3 .   ? 107.433 113.330 129.207 1.00 20.00  ? 414 D12 U H102 1 
HETATM 4659 H H111 . D12 P  3 .   ? 109.754 115.081 130.008 1.00 20.00  ? 414 D12 U H111 1 
HETATM 4660 H H112 . D12 P  3 .   ? 108.837 115.128 128.497 1.00 20.00  ? 414 D12 U H112 1 
HETATM 4661 H H121 . D12 P  3 .   ? 110.003 113.408 127.597 1.00 20.00  ? 414 D12 U H121 1 
HETATM 4662 H H122 . D12 P  3 .   ? 111.209 113.814 128.833 1.00 20.00  ? 414 D12 U H122 1 
HETATM 4663 H H123 . D12 P  3 .   ? 110.043 112.510 129.125 1.00 20.00  ? 414 D12 U H123 1 
HETATM 4664 C C1   . D12 Q  3 .   ? 128.737 99.197  120.126 1.00 20.00  ? 401 D12 A C1   1 
HETATM 4665 C C2   . D12 Q  3 .   ? 128.378 98.093  119.143 1.00 20.00  ? 401 D12 A C2   1 
HETATM 4666 C C3   . D12 Q  3 .   ? 129.408 97.990  118.029 1.00 20.00  ? 401 D12 A C3   1 
HETATM 4667 C C4   . D12 Q  3 .   ? 128.901 97.248  116.800 1.00 20.00  ? 401 D12 A C4   1 
HETATM 4668 C C5   . D12 Q  3 .   ? 129.382 97.924  115.524 1.00 20.00  ? 401 D12 A C5   1 
HETATM 4669 C C6   . D12 Q  3 .   ? 129.517 96.944  114.372 1.00 20.00  ? 401 D12 A C6   1 
HETATM 4670 C C7   . D12 Q  3 .   ? 129.521 97.657  113.031 1.00 20.00  ? 401 D12 A C7   1 
HETATM 4671 C C8   . D12 Q  3 .   ? 130.445 96.981  112.033 1.00 20.00  ? 401 D12 A C8   1 
HETATM 4672 C C9   . D12 Q  3 .   ? 129.794 96.760  110.676 1.00 20.00  ? 401 D12 A C9   1 
HETATM 4673 C C10  . D12 Q  3 .   ? 130.811 96.833  109.544 1.00 20.00  ? 401 D12 A C10  1 
HETATM 4674 C C11  . D12 Q  3 .   ? 130.668 95.685  108.557 1.00 20.00  ? 401 D12 A C11  1 
HETATM 4675 C C12  . D12 Q  3 .   ? 131.588 95.831  107.351 1.00 20.00  ? 401 D12 A C12  1 
HETATM 4676 H H11  . D12 Q  3 .   ? 128.097 99.128  121.001 1.00 20.00  ? 401 D12 A H11  1 
HETATM 4677 H H12  . D12 Q  3 .   ? 128.597 100.162 119.648 1.00 20.00  ? 401 D12 A H12  1 
HETATM 4678 H H13  . D12 Q  3 .   ? 129.775 99.087  120.423 1.00 20.00  ? 401 D12 A H13  1 
HETATM 4679 H H21  . D12 Q  3 .   ? 127.407 98.308  118.710 1.00 20.00  ? 401 D12 A H21  1 
HETATM 4680 H H22  . D12 Q  3 .   ? 128.333 97.147  119.673 1.00 20.00  ? 401 D12 A H22  1 
HETATM 4681 H H31  . D12 Q  3 .   ? 130.284 97.478  118.409 1.00 20.00  ? 401 D12 A H31  1 
HETATM 4682 H H32  . D12 Q  3 .   ? 129.691 98.994  117.732 1.00 20.00  ? 401 D12 A H32  1 
HETATM 4683 H H41  . D12 Q  3 .   ? 127.817 97.239  116.809 1.00 20.00  ? 401 D12 A H41  1 
HETATM 4684 H H42  . D12 Q  3 .   ? 129.269 96.228  116.820 1.00 20.00  ? 401 D12 A H42  1 
HETATM 4685 H H51  . D12 Q  3 .   ? 128.671 98.694  115.244 1.00 20.00  ? 401 D12 A H51  1 
HETATM 4686 H H52  . D12 Q  3 .   ? 130.347 98.383  115.710 1.00 20.00  ? 401 D12 A H52  1 
HETATM 4687 H H61  . D12 Q  3 .   ? 130.444 96.395  114.488 1.00 20.00  ? 401 D12 A H61  1 
HETATM 4688 H H62  . D12 Q  3 .   ? 128.684 96.249  114.402 1.00 20.00  ? 401 D12 A H62  1 
HETATM 4689 H H71  . D12 Q  3 .   ? 128.511 97.662  112.636 1.00 20.00  ? 401 D12 A H71  1 
HETATM 4690 H H72  . D12 Q  3 .   ? 129.849 98.680  113.180 1.00 20.00  ? 401 D12 A H72  1 
HETATM 4691 H H81  . D12 Q  3 .   ? 130.748 96.020  112.430 1.00 20.00  ? 401 D12 A H81  1 
HETATM 4692 H H82  . D12 Q  3 .   ? 131.326 97.600  111.902 1.00 20.00  ? 401 D12 A H82  1 
HETATM 4693 H H91  . D12 Q  3 .   ? 129.035 97.519  110.519 1.00 20.00  ? 401 D12 A H91  1 
HETATM 4694 H H92  . D12 Q  3 .   ? 129.326 95.781  110.665 1.00 20.00  ? 401 D12 A H92  1 
HETATM 4695 H H101 . D12 Q  3 .   ? 130.682 97.770  109.015 1.00 20.00  ? 401 D12 A H101 1 
HETATM 4696 H H102 . D12 Q  3 .   ? 131.808 96.802  109.969 1.00 20.00  ? 401 D12 A H102 1 
HETATM 4697 H H111 . D12 Q  3 .   ? 129.641 95.649  108.212 1.00 20.00  ? 401 D12 A H111 1 
HETATM 4698 H H112 . D12 Q  3 .   ? 130.902 94.756  109.066 1.00 20.00  ? 401 D12 A H112 1 
HETATM 4699 H H121 . D12 Q  3 .   ? 131.103 96.452  106.604 1.00 20.00  ? 401 D12 A H121 1 
HETATM 4700 H H122 . D12 Q  3 .   ? 132.517 96.297  107.665 1.00 20.00  ? 401 D12 A H122 1 
HETATM 4701 H H123 . D12 Q  3 .   ? 131.794 94.851  106.933 1.00 20.00  ? 401 D12 A H123 1 
HETATM 4702 C C1   . HEX R  2 .   ? 135.902 98.337  116.802 1.00 20.00  ? 402 HEX A C1   1 
HETATM 4703 C C2   . HEX R  2 .   ? 135.926 98.887  115.383 1.00 20.00  ? 402 HEX A C2   1 
HETATM 4704 C C3   . HEX R  2 .   ? 136.299 97.823  114.368 1.00 20.00  ? 402 HEX A C3   1 
HETATM 4705 C C4   . HEX R  2 .   ? 136.436 98.439  112.983 1.00 20.00  ? 402 HEX A C4   1 
HETATM 4706 C C5   . HEX R  2 .   ? 135.393 97.944  112.003 1.00 20.00  ? 402 HEX A C5   1 
HETATM 4707 C C6   . HEX R  2 .   ? 136.107 97.639  110.705 1.00 20.00  ? 402 HEX A C6   1 
HETATM 4708 H H11  . HEX R  2 .   ? 134.990 97.773  116.950 1.00 20.00  ? 402 HEX A H11  1 
HETATM 4709 H H12  . HEX R  2 .   ? 135.941 99.160  117.504 1.00 20.00  ? 402 HEX A H12  1 
HETATM 4710 H H13  . HEX R  2 .   ? 136.758 97.691  116.946 1.00 20.00  ? 402 HEX A H13  1 
HETATM 4711 H H21  . HEX R  2 .   ? 136.650 99.690  115.330 1.00 20.00  ? 402 HEX A H21  1 
HETATM 4712 H H22  . HEX R  2 .   ? 134.947 99.276  115.137 1.00 20.00  ? 402 HEX A H22  1 
HETATM 4713 H H31  . HEX R  2 .   ? 135.530 97.062  114.363 1.00 20.00  ? 402 HEX A H31  1 
HETATM 4714 H H32  . HEX R  2 .   ? 137.241 97.378  114.656 1.00 20.00  ? 402 HEX A H32  1 
HETATM 4715 H H41  . HEX R  2 .   ? 136.342 99.514  113.074 1.00 20.00  ? 402 HEX A H41  1 
HETATM 4716 H H42  . HEX R  2 .   ? 137.417 98.205  112.592 1.00 20.00  ? 402 HEX A H42  1 
HETATM 4717 H H51  . HEX R  2 .   ? 134.920 97.044  112.372 1.00 20.00  ? 402 HEX A H51  1 
HETATM 4718 H H52  . HEX R  2 .   ? 134.649 98.712  111.840 1.00 20.00  ? 402 HEX A H52  1 
HETATM 4719 H H61  . HEX R  2 .   ? 136.649 98.519  110.382 1.00 20.00  ? 402 HEX A H61  1 
HETATM 4720 H H62  . HEX R  2 .   ? 135.379 97.362  109.953 1.00 20.00  ? 402 HEX A H62  1 
HETATM 4721 H H63  . HEX R  2 .   ? 136.799 96.822  110.861 1.00 20.00  ? 402 HEX A H63  1 
HETATM 4722 C C1   . OCT S  4 .   ? 111.443 99.227  119.140 1.00 20.00  ? 403 OCT A C1   1 
HETATM 4723 C C2   . OCT S  4 .   ? 110.629 99.613  117.914 1.00 20.00  ? 403 OCT A C2   1 
HETATM 4724 C C3   . OCT S  4 .   ? 111.525 100.083 116.781 1.00 20.00  ? 403 OCT A C3   1 
HETATM 4725 C C4   . OCT S  4 .   ? 110.941 99.767  115.411 1.00 20.00  ? 403 OCT A C4   1 
HETATM 4726 C C5   . OCT S  4 .   ? 111.956 99.120  114.481 1.00 20.00  ? 403 OCT A C5   1 
HETATM 4727 C C6   . OCT S  4 .   ? 112.199 99.960  113.242 1.00 20.00  ? 403 OCT A C6   1 
HETATM 4728 C C7   . OCT S  4 .   ? 111.133 99.743  112.186 1.00 20.00  ? 403 OCT A C7   1 
HETATM 4729 C C8   . OCT S  4 .   ? 111.742 99.673  110.793 1.00 20.00  ? 403 OCT A C8   1 
HETATM 4730 H H11  . OCT S  4 .   ? 111.766 98.198  119.048 1.00 20.00  ? 403 OCT A H11  1 
HETATM 4731 H H12  . OCT S  4 .   ? 112.309 99.873  119.211 1.00 20.00  ? 403 OCT A H12  1 
HETATM 4732 H H13  . OCT S  4 .   ? 110.834 99.337  120.029 1.00 20.00  ? 403 OCT A H13  1 
HETATM 4733 H H21  . OCT S  4 .   ? 109.946 100.411 118.178 1.00 20.00  ? 403 OCT A H21  1 
HETATM 4734 H H22  . OCT S  4 .   ? 110.060 98.752  117.587 1.00 20.00  ? 403 OCT A H22  1 
HETATM 4735 H H31  . OCT S  4 .   ? 111.662 101.154 116.864 1.00 20.00  ? 403 OCT A H31  1 
HETATM 4736 H H32  . OCT S  4 .   ? 112.487 99.598  116.885 1.00 20.00  ? 403 OCT A H32  1 
HETATM 4737 H H41  . OCT S  4 .   ? 110.100 99.096  115.529 1.00 20.00  ? 403 OCT A H41  1 
HETATM 4738 H H42  . OCT S  4 .   ? 110.592 100.688 114.960 1.00 20.00  ? 403 OCT A H42  1 
HETATM 4739 H H51  . OCT S  4 .   ? 111.587 98.148  114.180 1.00 20.00  ? 403 OCT A H51  1 
HETATM 4740 H H52  . OCT S  4 .   ? 112.895 98.991  115.001 1.00 20.00  ? 403 OCT A H52  1 
HETATM 4741 H H61  . OCT S  4 .   ? 112.208 101.005 113.524 1.00 20.00  ? 403 OCT A H61  1 
HETATM 4742 H H62  . OCT S  4 .   ? 113.162 99.699  112.824 1.00 20.00  ? 403 OCT A H62  1 
HETATM 4743 H H71  . OCT S  4 .   ? 110.613 98.816  112.391 1.00 20.00  ? 403 OCT A H71  1 
HETATM 4744 H H72  . OCT S  4 .   ? 110.426 100.562 112.224 1.00 20.00  ? 403 OCT A H72  1 
HETATM 4745 H H81  . OCT S  4 .   ? 110.954 99.539  110.062 1.00 20.00  ? 403 OCT A H81  1 
HETATM 4746 H H82  . OCT S  4 .   ? 112.274 100.593 110.590 1.00 20.00  ? 403 OCT A H82  1 
HETATM 4747 H H83  . OCT S  4 .   ? 112.429 98.838  110.745 1.00 20.00  ? 403 OCT A H83  1 
HETATM 4748 C C27  . R16 T  5 .   ? 117.857 97.310  108.384 1.00 20.00  ? 404 R16 A C27  1 
HETATM 4749 C C28  . R16 T  5 .   ? 117.050 98.576  108.583 1.00 20.00  ? 404 R16 A C28  1 
HETATM 4750 C C29  . R16 T  5 .   ? 116.593 98.704  110.024 1.00 20.00  ? 404 R16 A C29  1 
HETATM 4751 C C30  . R16 T  5 .   ? 117.004 100.031 110.632 1.00 20.00  ? 404 R16 A C30  1 
HETATM 4752 C C31  . R16 T  5 .   ? 116.877 100.011 112.154 1.00 20.00  ? 404 R16 A C31  1 
HETATM 4753 C C32  . R16 T  5 .   ? 117.929 100.884 112.832 1.00 20.00  ? 404 R16 A C32  1 
HETATM 4754 C C33  . R16 T  5 .   ? 117.725 100.914 114.344 1.00 20.00  ? 404 R16 A C33  1 
HETATM 4755 C C34  . R16 T  5 .   ? 116.621 101.905 114.704 1.00 20.00  ? 404 R16 A C34  1 
HETATM 4756 C C35  . R16 T  5 .   ? 117.145 103.022 115.602 1.00 20.00  ? 404 R16 A C35  1 
HETATM 4757 C C36  . R16 T  5 .   ? 117.481 102.553 117.013 1.00 20.00  ? 404 R16 A C36  1 
HETATM 4758 C C37  . R16 T  5 .   ? 116.283 101.932 117.719 1.00 20.00  ? 404 R16 A C37  1 
HETATM 4759 C C38  . R16 T  5 .   ? 116.076 102.494 119.107 1.00 20.00  ? 404 R16 A C38  1 
HETATM 4760 C C39  . R16 T  5 .   ? 117.262 102.282 119.971 1.00 20.00  ? 404 R16 A C39  1 
HETATM 4761 C C40  . R16 T  5 .   ? 116.905 102.548 121.383 1.00 20.00  ? 404 R16 A C40  1 
HETATM 4762 C C41  . R16 T  5 .   ? 116.366 101.319 122.037 1.00 20.00  ? 404 R16 A C41  1 
HETATM 4763 C C42  . R16 T  5 .   ? 116.784 101.268 123.476 1.00 20.00  ? 404 R16 A C42  1 
HETATM 4764 H H271 . R16 T  5 .   ? 117.963 97.035  107.327 1.00 20.00  ? 404 R16 A H271 1 
HETATM 4765 H H272 . R16 T  5 .   ? 117.413 96.448  108.897 1.00 20.00  ? 404 R16 A H272 1 
HETATM 4766 H H273 . R16 T  5 .   ? 118.880 97.409  108.776 1.00 20.00  ? 404 R16 A H273 1 
HETATM 4767 H H281 . R16 T  5 .   ? 116.179 98.578  107.900 1.00 20.00  ? 404 R16 A H281 1 
HETATM 4768 H H282 . R16 T  5 .   ? 117.642 99.461  108.279 1.00 20.00  ? 404 R16 A H282 1 
HETATM 4769 H H291 . R16 T  5 .   ? 115.492 98.581  110.081 1.00 20.00  ? 404 R16 A H291 1 
HETATM 4770 H H292 . R16 T  5 .   ? 116.994 97.862  110.620 1.00 20.00  ? 404 R16 A H292 1 
HETATM 4771 H H301 . R16 T  5 .   ? 118.042 100.282 110.335 1.00 20.00  ? 404 R16 A H301 1 
HETATM 4772 H H302 . R16 T  5 .   ? 116.383 100.848 110.213 1.00 20.00  ? 404 R16 A H302 1 
HETATM 4773 H H311 . R16 T  5 .   ? 115.861 100.334 112.455 1.00 20.00  ? 404 R16 A H311 1 
HETATM 4774 H H312 . R16 T  5 .   ? 116.951 98.968  112.526 1.00 20.00  ? 404 R16 A H312 1 
HETATM 4775 H H321 . R16 T  5 .   ? 118.947 100.518 112.580 1.00 20.00  ? 404 R16 A H321 1 
HETATM 4776 H H322 . R16 T  5 .   ? 117.901 101.912 112.420 1.00 20.00  ? 404 R16 A H322 1 
HETATM 4777 H H331 . R16 T  5 .   ? 117.481 99.900  114.719 1.00 20.00  ? 404 R16 A H331 1 
HETATM 4778 H H332 . R16 T  5 .   ? 118.671 101.186 114.853 1.00 20.00  ? 404 R16 A H332 1 
HETATM 4779 H H341 . R16 T  5 .   ? 115.769 101.372 115.167 1.00 20.00  ? 404 R16 A H341 1 
HETATM 4780 H H342 . R16 T  5 .   ? 116.191 102.343 113.780 1.00 20.00  ? 404 R16 A H342 1 
HETATM 4781 H H351 . R16 T  5 .   ? 116.406 103.847 115.650 1.00 20.00  ? 404 R16 A H351 1 
HETATM 4782 H H352 . R16 T  5 .   ? 118.038 103.483 115.136 1.00 20.00  ? 404 R16 A H352 1 
HETATM 4783 H H361 . R16 T  5 .   ? 117.863 103.416 117.591 1.00 20.00  ? 404 R16 A H361 1 
HETATM 4784 H H362 . R16 T  5 .   ? 118.325 101.837 116.995 1.00 20.00  ? 404 R16 A H362 1 
HETATM 4785 H H371 . R16 T  5 .   ? 116.398 100.832 117.771 1.00 20.00  ? 404 R16 A H371 1 
HETATM 4786 H H372 . R16 T  5 .   ? 115.364 102.086 117.125 1.00 20.00  ? 404 R16 A H372 1 
HETATM 4787 H H381 . R16 T  5 .   ? 115.176 102.048 119.572 1.00 20.00  ? 404 R16 A H381 1 
HETATM 4788 H H382 . R16 T  5 .   ? 115.845 103.576 119.043 1.00 20.00  ? 404 R16 A H382 1 
HETATM 4789 H H391 . R16 T  5 .   ? 117.655 101.255 119.847 1.00 20.00  ? 404 R16 A H391 1 
HETATM 4790 H H392 . R16 T  5 .   ? 118.096 102.943 119.669 1.00 20.00  ? 404 R16 A H392 1 
HETATM 4791 H H401 . R16 T  5 .   ? 116.165 103.368 121.443 1.00 20.00  ? 404 R16 A H401 1 
HETATM 4792 H H402 . R16 T  5 .   ? 117.785 102.924 121.939 1.00 20.00  ? 404 R16 A H402 1 
HETATM 4793 H H411 . R16 T  5 .   ? 116.701 100.408 121.506 1.00 20.00  ? 404 R16 A H411 1 
HETATM 4794 H H412 . R16 T  5 .   ? 115.261 101.314 121.959 1.00 20.00  ? 404 R16 A H412 1 
HETATM 4795 H H421 . R16 T  5 .   ? 117.788 101.679 123.632 1.00 20.00  ? 404 R16 A H421 1 
HETATM 4796 H H422 . R16 T  5 .   ? 116.120 101.848 124.129 1.00 20.00  ? 404 R16 A H422 1 
HETATM 4797 H H423 . R16 T  5 .   ? 116.809 100.244 123.871 1.00 20.00  ? 404 R16 A H423 1 
HETATM 4798 C C1   . OCT U  4 .   ? 119.467 96.544  122.309 1.00 20.00  ? 405 OCT A C1   1 
HETATM 4799 C C2   . OCT U  4 .   ? 118.733 96.089  121.055 1.00 20.00  ? 405 OCT A C2   1 
HETATM 4800 C C3   . OCT U  4 .   ? 119.684 95.845  119.892 1.00 20.00  ? 405 OCT A C3   1 
HETATM 4801 C C4   . OCT U  4 .   ? 119.085 96.292  118.568 1.00 20.00  ? 405 OCT A C4   1 
HETATM 4802 C C5   . OCT U  4 .   ? 120.124 96.322  117.461 1.00 20.00  ? 405 OCT A C5   1 
HETATM 4803 C C6   . OCT U  4 .   ? 119.987 95.133  116.529 1.00 20.00  ? 405 OCT A C6   1 
HETATM 4804 C C7   . OCT U  4 .   ? 119.071 95.427  115.353 1.00 20.00  ? 405 OCT A C7   1 
HETATM 4805 C C8   . OCT U  4 .   ? 119.390 94.518  114.175 1.00 20.00  ? 405 OCT A C8   1 
HETATM 4806 H H11  . OCT U  4 .   ? 119.971 97.480  122.108 1.00 20.00  ? 405 OCT A H11  1 
HETATM 4807 H H12  . OCT U  4 .   ? 118.756 96.680  123.114 1.00 20.00  ? 405 OCT A H12  1 
HETATM 4808 H H13  . OCT U  4 .   ? 120.195 95.793  122.589 1.00 20.00  ? 405 OCT A H13  1 
HETATM 4809 H H21  . OCT U  4 .   ? 118.019 96.851  120.771 1.00 20.00  ? 405 OCT A H21  1 
HETATM 4810 H H22  . OCT U  4 .   ? 118.201 95.171  121.273 1.00 20.00  ? 405 OCT A H22  1 
HETATM 4811 H H31  . OCT U  4 .   ? 120.599 96.395  120.069 1.00 20.00  ? 405 OCT A H31  1 
HETATM 4812 H H32  . OCT U  4 .   ? 119.911 94.788  119.836 1.00 20.00  ? 405 OCT A H32  1 
HETATM 4813 H H41  . OCT U  4 .   ? 118.293 95.607  118.290 1.00 20.00  ? 405 OCT A H41  1 
HETATM 4814 H H42  . OCT U  4 .   ? 118.670 97.284  118.687 1.00 20.00  ? 405 OCT A H42  1 
HETATM 4815 H H51  . OCT U  4 .   ? 121.110 96.306  117.908 1.00 20.00  ? 405 OCT A H51  1 
HETATM 4816 H H52  . OCT U  4 .   ? 120.008 97.236  116.892 1.00 20.00  ? 405 OCT A H52  1 
HETATM 4817 H H61  . OCT U  4 .   ? 120.965 94.868  116.150 1.00 20.00  ? 405 OCT A H61  1 
HETATM 4818 H H62  . OCT U  4 .   ? 119.585 94.296  117.085 1.00 20.00  ? 405 OCT A H62  1 
HETATM 4819 H H71  . OCT U  4 .   ? 118.044 95.271  115.656 1.00 20.00  ? 405 OCT A H71  1 
HETATM 4820 H H72  . OCT U  4 .   ? 119.202 96.458  115.049 1.00 20.00  ? 405 OCT A H72  1 
HETATM 4821 H H81  . OCT U  4 .   ? 119.212 93.489  114.459 1.00 20.00  ? 405 OCT A H81  1 
HETATM 4822 H H82  . OCT U  4 .   ? 118.757 94.780  113.337 1.00 20.00  ? 405 OCT A H82  1 
HETATM 4823 H H83  . OCT U  4 .   ? 120.429 94.643  113.898 1.00 20.00  ? 405 OCT A H83  1 
HETATM 4824 C C1   . OCT V  4 .   ? 148.634 131.829 118.169 1.00 20.00  ? 406 OCT A C1   1 
HETATM 4825 C C2   . OCT V  4 .   ? 148.969 132.956 117.198 1.00 20.00  ? 406 OCT A C2   1 
HETATM 4826 C C3   . OCT V  4 .   ? 149.333 132.442 115.808 1.00 20.00  ? 406 OCT A C3   1 
HETATM 4827 C C4   . OCT V  4 .   ? 148.761 133.322 114.705 1.00 20.00  ? 406 OCT A C4   1 
HETATM 4828 C C5   . OCT V  4 .   ? 149.752 133.569 113.580 1.00 20.00  ? 406 OCT A C5   1 
HETATM 4829 C C6   . OCT V  4 .   ? 149.754 132.437 112.571 1.00 20.00  ? 406 OCT A C6   1 
HETATM 4830 C C7   . OCT V  4 .   ? 149.061 132.821 111.276 1.00 20.00  ? 406 OCT A C7   1 
HETATM 4831 C C8   . OCT V  4 .   ? 150.044 133.320 110.229 1.00 20.00  ? 406 OCT A C8   1 
HETATM 4832 H H11  . OCT V  4 .   ? 147.651 131.438 117.938 1.00 20.00  ? 406 OCT A H11  1 
HETATM 4833 H H12  . OCT V  4 .   ? 149.370 131.042 118.069 1.00 20.00  ? 406 OCT A H12  1 
HETATM 4834 H H13  . OCT V  4 .   ? 148.646 132.211 119.182 1.00 20.00  ? 406 OCT A H13  1 
HETATM 4835 H H21  . OCT V  4 .   ? 149.803 133.522 117.591 1.00 20.00  ? 406 OCT A H21  1 
HETATM 4836 H H22  . OCT V  4 .   ? 148.108 133.607 117.115 1.00 20.00  ? 406 OCT A H22  1 
HETATM 4837 H H31  . OCT V  4 .   ? 150.411 132.414 115.716 1.00 20.00  ? 406 OCT A H31  1 
HETATM 4838 H H32  . OCT V  4 .   ? 148.944 131.439 115.694 1.00 20.00  ? 406 OCT A H32  1 
HETATM 4839 H H41  . OCT V  4 .   ? 147.881 132.843 114.295 1.00 20.00  ? 406 OCT A H41  1 
HETATM 4840 H H42  . OCT V  4 .   ? 148.477 134.276 115.129 1.00 20.00  ? 406 OCT A H42  1 
HETATM 4841 H H51  . OCT V  4 .   ? 150.744 133.669 114.000 1.00 20.00  ? 406 OCT A H51  1 
HETATM 4842 H H52  . OCT V  4 .   ? 149.489 134.490 113.076 1.00 20.00  ? 406 OCT A H52  1 
HETATM 4843 H H61  . OCT V  4 .   ? 150.779 132.167 112.348 1.00 20.00  ? 406 OCT A H61  1 
HETATM 4844 H H62  . OCT V  4 .   ? 149.248 131.581 113.000 1.00 20.00  ? 406 OCT A H62  1 
HETATM 4845 H H71  . OCT V  4 .   ? 148.543 131.953 110.886 1.00 20.00  ? 406 OCT A H71  1 
HETATM 4846 H H72  . OCT V  4 .   ? 148.338 133.599 111.481 1.00 20.00  ? 406 OCT A H72  1 
HETATM 4847 H H81  . OCT V  4 .   ? 150.760 133.982 110.699 1.00 20.00  ? 406 OCT A H81  1 
HETATM 4848 H H82  . OCT V  4 .   ? 150.564 132.476 109.793 1.00 20.00  ? 406 OCT A H82  1 
HETATM 4849 H H83  . OCT V  4 .   ? 149.507 133.855 109.456 1.00 20.00  ? 406 OCT A H83  1 
HETATM 4850 C C1   . OCT W  4 .   ? 146.123 117.260 117.615 1.00 20.00  ? 407 OCT A C1   1 
HETATM 4851 C C2   . OCT W  4 .   ? 145.909 116.908 116.150 1.00 20.00  ? 407 OCT A C2   1 
HETATM 4852 C C3   . OCT W  4 .   ? 147.203 116.921 115.348 1.00 20.00  ? 407 OCT A C3   1 
HETATM 4853 C C4   . OCT W  4 .   ? 146.993 117.490 113.954 1.00 20.00  ? 407 OCT A C4   1 
HETATM 4854 C C5   . OCT W  4 .   ? 147.901 116.870 112.904 1.00 20.00  ? 407 OCT A C5   1 
HETATM 4855 C C6   . OCT W  4 .   ? 147.258 116.923 111.529 1.00 20.00  ? 407 OCT A C6   1 
HETATM 4856 C C7   . OCT W  4 .   ? 148.048 116.132 110.506 1.00 20.00  ? 407 OCT A C7   1 
HETATM 4857 C C8   . OCT W  4 .   ? 147.965 116.751 109.118 1.00 20.00  ? 407 OCT A C8   1 
HETATM 4858 H H11  . OCT W  4 .   ? 145.262 116.949 118.191 1.00 20.00  ? 407 OCT A H11  1 
HETATM 4859 H H12  . OCT W  4 .   ? 147.007 116.751 117.978 1.00 20.00  ? 407 OCT A H12  1 
HETATM 4860 H H13  . OCT W  4 .   ? 146.257 118.331 117.710 1.00 20.00  ? 407 OCT A H13  1 
HETATM 4861 H H21  . OCT W  4 .   ? 145.224 117.625 115.716 1.00 20.00  ? 407 OCT A H21  1 
HETATM 4862 H H22  . OCT W  4 .   ? 145.470 115.920 116.088 1.00 20.00  ? 407 OCT A H22  1 
HETATM 4863 H H31  . OCT W  4 .   ? 147.931 117.528 115.870 1.00 20.00  ? 407 OCT A H31  1 
HETATM 4864 H H32  . OCT W  4 .   ? 147.577 115.909 115.265 1.00 20.00  ? 407 OCT A H32  1 
HETATM 4865 H H41  . OCT W  4 .   ? 145.965 117.318 113.662 1.00 20.00  ? 407 OCT A H41  1 
HETATM 4866 H H42  . OCT W  4 .   ? 147.174 118.558 113.982 1.00 20.00  ? 407 OCT A H42  1 
HETATM 4867 H H51  . OCT W  4 .   ? 148.093 115.837 113.163 1.00 20.00  ? 407 OCT A H51  1 
HETATM 4868 H H52  . OCT W  4 .   ? 148.838 117.412 112.878 1.00 20.00  ? 407 OCT A H52  1 
HETATM 4869 H H61  . OCT W  4 .   ? 146.257 116.516 111.593 1.00 20.00  ? 407 OCT A H61  1 
HETATM 4870 H H62  . OCT W  4 .   ? 147.200 117.955 111.207 1.00 20.00  ? 407 OCT A H62  1 
HETATM 4871 H H71  . OCT W  4 .   ? 149.084 116.099 110.815 1.00 20.00  ? 407 OCT A H71  1 
HETATM 4872 H H72  . OCT W  4 .   ? 147.659 115.122 110.465 1.00 20.00  ? 407 OCT A H72  1 
HETATM 4873 H H81  . OCT W  4 .   ? 148.411 116.081 108.396 1.00 20.00  ? 407 OCT A H81  1 
HETATM 4874 H H82  . OCT W  4 .   ? 146.926 116.920 108.865 1.00 20.00  ? 407 OCT A H82  1 
HETATM 4875 H H83  . OCT W  4 .   ? 148.496 117.695 109.116 1.00 20.00  ? 407 OCT A H83  1 
HETATM 4876 C C1   . OCT X  4 .   ? 143.742 141.457 121.717 1.00 20.00  ? 408 OCT A C1   1 
HETATM 4877 C C2   . OCT X  4 .   ? 142.835 142.344 120.874 1.00 20.00  ? 408 OCT A C2   1 
HETATM 4878 C C3   . OCT X  4 .   ? 143.454 142.690 119.528 1.00 20.00  ? 408 OCT A C3   1 
HETATM 4879 C C4   . OCT X  4 .   ? 142.508 143.519 118.672 1.00 20.00  ? 408 OCT A C4   1 
HETATM 4880 C C5   . OCT X  4 .   ? 142.699 143.201 117.198 1.00 20.00  ? 408 OCT A C5   1 
HETATM 4881 C C6   . OCT X  4 .   ? 142.019 144.206 116.278 1.00 20.00  ? 408 OCT A C6   1 
HETATM 4882 C C7   . OCT X  4 .   ? 142.842 144.438 115.014 1.00 20.00  ? 408 OCT A C7   1 
HETATM 4883 C C8   . OCT X  4 .   ? 142.097 145.265 113.973 1.00 20.00  ? 408 OCT A C8   1 
HETATM 4884 H H11  . OCT X  4 .   ? 143.204 140.564 122.009 1.00 20.00  ? 408 OCT A H11  1 
HETATM 4885 H H12  . OCT X  4 .   ? 144.612 141.183 121.134 1.00 20.00  ? 408 OCT A H12  1 
HETATM 4886 H H13  . OCT X  4 .   ? 144.054 141.998 122.601 1.00 20.00  ? 408 OCT A H13  1 
HETATM 4887 H H21  . OCT X  4 .   ? 142.639 143.262 121.413 1.00 20.00  ? 408 OCT A H21  1 
HETATM 4888 H H22  . OCT X  4 .   ? 141.898 141.829 120.704 1.00 20.00  ? 408 OCT A H22  1 
HETATM 4889 H H31  . OCT X  4 .   ? 144.365 143.250 119.692 1.00 20.00  ? 408 OCT A H31  1 
HETATM 4890 H H32  . OCT X  4 .   ? 143.690 141.774 119.002 1.00 20.00  ? 408 OCT A H32  1 
HETATM 4891 H H41  . OCT X  4 .   ? 141.487 143.297 118.954 1.00 20.00  ? 408 OCT A H41  1 
HETATM 4892 H H42  . OCT X  4 .   ? 142.706 144.569 118.837 1.00 20.00  ? 408 OCT A H42  1 
HETATM 4893 H H51  . OCT X  4 .   ? 142.294 142.217 117.001 1.00 20.00  ? 408 OCT A H51  1 
HETATM 4894 H H52  . OCT X  4 .   ? 143.758 143.194 116.980 1.00 20.00  ? 408 OCT A H52  1 
HETATM 4895 H H61  . OCT X  4 .   ? 141.042 143.830 116.000 1.00 20.00  ? 408 OCT A H61  1 
HETATM 4896 H H62  . OCT X  4 .   ? 141.904 145.145 116.803 1.00 20.00  ? 408 OCT A H62  1 
HETATM 4897 H H71  . OCT X  4 .   ? 143.755 144.954 115.284 1.00 20.00  ? 408 OCT A H71  1 
HETATM 4898 H H72  . OCT X  4 .   ? 143.096 143.477 114.584 1.00 20.00  ? 408 OCT A H72  1 
HETATM 4899 H H81  . OCT X  4 .   ? 141.685 144.606 113.219 1.00 20.00  ? 408 OCT A H81  1 
HETATM 4900 H H82  . OCT X  4 .   ? 141.296 145.808 114.458 1.00 20.00  ? 408 OCT A H82  1 
HETATM 4901 H H83  . OCT X  4 .   ? 142.782 145.963 113.509 1.00 20.00  ? 408 OCT A H83  1 
HETATM 4902 C C1   . D12 Y  3 .   ? 124.384 106.634 128.997 1.00 20.00  ? 409 D12 A C1   1 
HETATM 4903 C C2   . D12 Y  3 .   ? 123.165 106.162 129.783 1.00 20.00  ? 409 D12 A C2   1 
HETATM 4904 C C3   . D12 Y  3 .   ? 122.504 104.939 129.160 1.00 20.00  ? 409 D12 A C3   1 
HETATM 4905 C C4   . D12 Y  3 .   ? 122.400 103.763 130.121 1.00 20.00  ? 409 D12 A C4   1 
HETATM 4906 C C5   . D12 Y  3 .   ? 121.144 103.802 130.978 1.00 20.00  ? 409 D12 A C5   1 
HETATM 4907 C C6   . D12 Y  3 .   ? 120.988 102.524 131.787 1.00 20.00  ? 409 D12 A C6   1 
HETATM 4908 C C7   . D12 Y  3 .   ? 120.689 102.799 133.252 1.00 20.00  ? 409 D12 A C7   1 
HETATM 4909 C C8   . D12 Y  3 .   ? 121.047 101.606 134.128 1.00 20.00  ? 409 D12 A C8   1 
HETATM 4910 C C9   . D12 Y  3 .   ? 120.749 101.882 135.595 1.00 20.00  ? 409 D12 A C9   1 
HETATM 4911 C C10  . D12 Y  3 .   ? 120.270 100.642 136.329 1.00 20.00  ? 409 D12 A C10  1 
HETATM 4912 C C11  . D12 Y  3 .   ? 121.405 99.687  136.646 1.00 20.00  ? 409 D12 A C11  1 
HETATM 4913 C C12  . D12 Y  3 .   ? 121.372 99.258  138.106 1.00 20.00  ? 409 D12 A C12  1 
HETATM 4914 H H11  . D12 Y  3 .   ? 124.823 107.493 129.494 1.00 20.00  ? 409 D12 A H11  1 
HETATM 4915 H H12  . D12 Y  3 .   ? 124.078 106.911 127.992 1.00 20.00  ? 409 D12 A H12  1 
HETATM 4916 H H13  . D12 Y  3 .   ? 125.110 105.830 128.947 1.00 20.00  ? 409 D12 A H13  1 
HETATM 4917 H H21  . D12 Y  3 .   ? 122.441 106.967 129.823 1.00 20.00  ? 409 D12 A H21  1 
HETATM 4918 H H22  . D12 Y  3 .   ? 123.474 105.917 130.793 1.00 20.00  ? 409 D12 A H22  1 
HETATM 4919 H H31  . D12 Y  3 .   ? 123.086 104.635 128.297 1.00 20.00  ? 409 D12 A H31  1 
HETATM 4920 H H32  . D12 Y  3 .   ? 121.506 105.209 128.833 1.00 20.00  ? 409 D12 A H32  1 
HETATM 4921 H H41  . D12 Y  3 .   ? 123.267 103.764 130.773 1.00 20.00  ? 409 D12 A H41  1 
HETATM 4922 H H42  . D12 Y  3 .   ? 122.398 102.842 129.547 1.00 20.00  ? 409 D12 A H42  1 
HETATM 4923 H H51  . D12 Y  3 .   ? 121.206 104.647 131.655 1.00 20.00  ? 409 D12 A H51  1 
HETATM 4924 H H52  . D12 Y  3 .   ? 120.280 103.925 130.334 1.00 20.00  ? 409 D12 A H52  1 
HETATM 4925 H H61  . D12 Y  3 .   ? 120.179 101.936 131.367 1.00 20.00  ? 409 D12 A H61  1 
HETATM 4926 H H62  . D12 Y  3 .   ? 121.910 101.955 131.721 1.00 20.00  ? 409 D12 A H62  1 
HETATM 4927 H H71  . D12 Y  3 .   ? 121.266 103.657 133.577 1.00 20.00  ? 409 D12 A H71  1 
HETATM 4928 H H72  . D12 Y  3 .   ? 119.633 103.016 133.364 1.00 20.00  ? 409 D12 A H72  1 
HETATM 4929 H H81  . D12 Y  3 .   ? 122.104 101.391 134.017 1.00 20.00  ? 409 D12 A H81  1 
HETATM 4930 H H82  . D12 Y  3 .   ? 120.472 100.745 133.805 1.00 20.00  ? 409 D12 A H82  1 
HETATM 4931 H H91  . D12 Y  3 .   ? 119.981 102.645 135.655 1.00 20.00  ? 409 D12 A H91  1 
HETATM 4932 H H92  . D12 Y  3 .   ? 121.649 102.249 136.074 1.00 20.00  ? 409 D12 A H92  1 
HETATM 4933 H H101 . D12 Y  3 .   ? 119.801 100.945 137.258 1.00 20.00  ? 409 D12 A H101 1 
HETATM 4934 H H102 . D12 Y  3 .   ? 119.539 100.130 135.713 1.00 20.00  ? 409 D12 A H102 1 
HETATM 4935 H H111 . D12 Y  3 .   ? 122.350 100.179 136.443 1.00 20.00  ? 409 D12 A H111 1 
HETATM 4936 H H112 . D12 Y  3 .   ? 121.317 98.810  136.015 1.00 20.00  ? 409 D12 A H112 1 
HETATM 4937 H H121 . D12 Y  3 .   ? 120.378 98.898  138.351 1.00 20.00  ? 409 D12 A H121 1 
HETATM 4938 H H122 . D12 Y  3 .   ? 122.096 98.467  138.267 1.00 20.00  ? 409 D12 A H122 1 
HETATM 4939 H H123 . D12 Y  3 .   ? 121.614 100.110 138.735 1.00 20.00  ? 409 D12 A H123 1 
HETATM 4940 C C1   . D12 Z  3 .   ? 142.813 133.891 121.590 1.00 20.00  ? 410 D12 A C1   1 
HETATM 4941 C C2   . D12 Z  3 .   ? 143.687 135.119 121.756 1.00 20.00  ? 410 D12 A C2   1 
HETATM 4942 C C3   . D12 Z  3 .   ? 145.083 134.865 121.219 1.00 20.00  ? 410 D12 A C3   1 
HETATM 4943 C C4   . D12 Z  3 .   ? 145.892 136.149 121.105 1.00 20.00  ? 410 D12 A C4   1 
HETATM 4944 C C5   . D12 Z  3 .   ? 145.607 136.888 119.807 1.00 20.00  ? 410 D12 A C5   1 
HETATM 4945 C C6   . D12 Z  3 .   ? 146.817 137.628 119.263 1.00 20.00  ? 410 D12 A C6   1 
HETATM 4946 C C7   . D12 Z  3 .   ? 146.448 138.409 118.012 1.00 20.00  ? 410 D12 A C7   1 
HETATM 4947 C C8   . D12 Z  3 .   ? 147.569 138.414 116.989 1.00 20.00  ? 410 D12 A C8   1 
HETATM 4948 C C9   . D12 Z  3 .   ? 147.078 138.864 115.624 1.00 20.00  ? 410 D12 A C9   1 
HETATM 4949 C C10  . D12 Z  3 .   ? 147.865 138.201 114.508 1.00 20.00  ? 410 D12 A C10  1 
HETATM 4950 C C11  . D12 Z  3 .   ? 147.818 139.008 113.224 1.00 20.00  ? 410 D12 A C11  1 
HETATM 4951 C C12  . D12 Z  3 .   ? 148.916 138.575 112.266 1.00 20.00  ? 410 D12 A C12  1 
HETATM 4952 H H11  . D12 Z  3 .   ? 141.963 134.135 120.962 1.00 20.00  ? 410 D12 A H11  1 
HETATM 4953 H H12  . D12 Z  3 .   ? 142.465 133.561 122.564 1.00 20.00  ? 410 D12 A H12  1 
HETATM 4954 H H13  . D12 Z  3 .   ? 143.393 133.100 121.124 1.00 20.00  ? 410 D12 A H13  1 
HETATM 4955 H H21  . D12 Z  3 .   ? 143.754 135.371 122.808 1.00 20.00  ? 410 D12 A H21  1 
HETATM 4956 H H22  . D12 Z  3 .   ? 143.244 135.948 121.216 1.00 20.00  ? 410 D12 A H22  1 
HETATM 4957 H H31  . D12 Z  3 .   ? 145.004 134.408 120.239 1.00 20.00  ? 410 D12 A H31  1 
HETATM 4958 H H32  . D12 Z  3 .   ? 145.597 134.183 121.887 1.00 20.00  ? 410 D12 A H32  1 
HETATM 4959 H H41  . D12 Z  3 .   ? 146.948 135.907 121.146 1.00 20.00  ? 410 D12 A H41  1 
HETATM 4960 H H42  . D12 Z  3 .   ? 145.642 136.794 121.940 1.00 20.00  ? 410 D12 A H42  1 
HETATM 4961 H H51  . D12 Z  3 .   ? 145.275 136.174 119.062 1.00 20.00  ? 410 D12 A H51  1 
HETATM 4962 H H52  . D12 Z  3 .   ? 144.811 137.604 119.983 1.00 20.00  ? 410 D12 A H52  1 
HETATM 4963 H H61  . D12 Z  3 .   ? 147.183 138.315 120.019 1.00 20.00  ? 410 D12 A H61  1 
HETATM 4964 H H62  . D12 Z  3 .   ? 147.593 136.912 119.022 1.00 20.00  ? 410 D12 A H62  1 
HETATM 4965 H H71  . D12 Z  3 .   ? 145.568 137.956 117.568 1.00 20.00  ? 410 D12 A H71  1 
HETATM 4966 H H72  . D12 Z  3 .   ? 146.218 139.432 118.288 1.00 20.00  ? 410 D12 A H72  1 
HETATM 4967 H H81  . D12 Z  3 .   ? 147.972 137.411 116.901 1.00 20.00  ? 410 D12 A H81  1 
HETATM 4968 H H82  . D12 Z  3 .   ? 148.351 139.084 117.324 1.00 20.00  ? 410 D12 A H82  1 
HETATM 4969 H H91  . D12 Z  3 .   ? 147.189 139.940 115.546 1.00 20.00  ? 410 D12 A H91  1 
HETATM 4970 H H92  . D12 Z  3 .   ? 146.030 138.606 115.520 1.00 20.00  ? 410 D12 A H92  1 
HETATM 4971 H H101 . D12 Z  3 .   ? 148.897 138.097 114.821 1.00 20.00  ? 410 D12 A H101 1 
HETATM 4972 H H102 . D12 Z  3 .   ? 147.450 137.217 114.321 1.00 20.00  ? 410 D12 A H102 1 
HETATM 4973 H H111 . D12 Z  3 .   ? 147.948 140.058 113.461 1.00 20.00  ? 410 D12 A H111 1 
HETATM 4974 H H112 . D12 Z  3 .   ? 146.854 138.864 112.750 1.00 20.00  ? 410 D12 A H112 1 
HETATM 4975 H H121 . D12 Z  3 .   ? 149.035 137.497 112.323 1.00 20.00  ? 410 D12 A H121 1 
HETATM 4976 H H122 . D12 Z  3 .   ? 148.646 138.860 111.253 1.00 20.00  ? 410 D12 A H122 1 
HETATM 4977 H H123 . D12 Z  3 .   ? 149.848 139.058 112.545 1.00 20.00  ? 410 D12 A H123 1 
HETATM 4978 C C1   . HEX AA 2 .   ? 125.474 103.376 138.483 1.00 20.00  ? 411 HEX A C1   1 
HETATM 4979 C C2   . HEX AA 2 .   ? 125.245 103.433 137.029 1.00 20.00  ? 411 HEX A C2   1 
HETATM 4980 C C3   . HEX AA 2 .   ? 126.390 104.020 136.335 1.00 20.00  ? 411 HEX A C3   1 
HETATM 4981 C C4   . HEX AA 2 .   ? 125.969 104.206 134.931 1.00 20.00  ? 411 HEX A C4   1 
HETATM 4982 C C5   . HEX AA 2 .   ? 126.881 103.982 133.751 1.00 20.00  ? 411 HEX A C5   1 
HETATM 4983 C C6   . HEX AA 2 .   ? 127.964 105.003 133.561 1.00 20.00  ? 411 HEX A C6   1 
HETATM 4984 H H11  . HEX AA 2 .   ? 125.620 104.380 138.858 1.00 20.00  ? 411 HEX A H11  1 
HETATM 4985 H H12  . HEX AA 2 .   ? 126.359 102.784 138.677 1.00 20.00  ? 411 HEX A H12  1 
HETATM 4986 H H13  . HEX AA 2 .   ? 124.616 102.924 138.965 1.00 20.00  ? 411 HEX A H13  1 
HETATM 4987 H H21  . HEX AA 2 .   ? 124.370 104.036 136.831 1.00 20.00  ? 411 HEX A H21  1 
HETATM 4988 H H22  . HEX AA 2 .   ? 125.084 102.429 136.658 1.00 20.00  ? 411 HEX A H22  1 
HETATM 4989 H H31  . HEX AA 2 .   ? 127.235 103.345 136.378 1.00 20.00  ? 411 HEX A H31  1 
HETATM 4990 H H32  . HEX AA 2 .   ? 126.645 104.971 136.781 1.00 20.00  ? 411 HEX A H32  1 
HETATM 4991 H H41  . HEX AA 2 .   ? 125.114 103.563 134.778 1.00 20.00  ? 411 HEX A H41  1 
HETATM 4992 H H42  . HEX AA 2 .   ? 125.618 105.227 134.851 1.00 20.00  ? 411 HEX A H42  1 
HETATM 4993 H H51  . HEX AA 2 .   ? 127.350 103.014 133.874 1.00 20.00  ? 411 HEX A H51  1 
HETATM 4994 H H52  . HEX AA 2 .   ? 126.276 103.960 132.855 1.00 20.00  ? 411 HEX A H52  1 
HETATM 4995 H H61  . HEX AA 2 .   ? 128.657 104.944 134.390 1.00 20.00  ? 411 HEX A H61  1 
HETATM 4996 H H62  . HEX AA 2 .   ? 127.518 105.989 133.530 1.00 20.00  ? 411 HEX A H62  1 
HETATM 4997 H H63  . HEX AA 2 .   ? 128.485 104.808 132.633 1.00 20.00  ? 411 HEX A H63  1 
HETATM 4998 C C1   . OCT BA 4 .   ? 99.688  121.293 118.817 1.00 20.00  ? 412 OCT A C1   1 
HETATM 4999 C C2   . OCT BA 4 .   ? 100.260 122.016 117.606 1.00 20.00  ? 412 OCT A C2   1 
HETATM 5000 C C3   . OCT BA 4 .   ? 99.409  121.816 116.365 1.00 20.00  ? 412 OCT A C3   1 
HETATM 5001 C C4   . OCT BA 4 .   ? 99.917  120.666 115.516 1.00 20.00  ? 412 OCT A C4   1 
HETATM 5002 C C5   . OCT BA 4 .   ? 98.877  120.208 114.514 1.00 20.00  ? 412 OCT A C5   1 
HETATM 5003 C C6   . OCT BA 4 .   ? 98.725  121.200 113.379 1.00 20.00  ? 412 OCT A C6   1 
HETATM 5004 C C7   . OCT BA 4 .   ? 97.989  120.568 112.214 1.00 20.00  ? 412 OCT A C7   1 
HETATM 5005 C C8   . OCT BA 4 .   ? 97.950  121.497 111.013 1.00 20.00  ? 412 OCT A C8   1 
HETATM 5006 H H11  . OCT BA 4 .   ? 98.720  121.711 119.058 1.00 20.00  ? 412 OCT A H11  1 
HETATM 5007 H H12  . OCT BA 4 .   ? 99.582  120.241 118.586 1.00 20.00  ? 412 OCT A H12  1 
HETATM 5008 H H13  . OCT BA 4 .   ? 100.358 121.414 119.659 1.00 20.00  ? 412 OCT A H13  1 
HETATM 5009 H H21  . OCT BA 4 .   ? 101.255 121.637 117.410 1.00 20.00  ? 412 OCT A H21  1 
HETATM 5010 H H22  . OCT BA 4 .   ? 100.320 123.074 117.826 1.00 20.00  ? 412 OCT A H22  1 
HETATM 5011 H H31  . OCT BA 4 .   ? 98.392  121.605 116.668 1.00 20.00  ? 412 OCT A H31  1 
HETATM 5012 H H32  . OCT BA 4 .   ? 99.424  122.724 115.775 1.00 20.00  ? 412 OCT A H32  1 
HETATM 5013 H H41  . OCT BA 4 .   ? 100.803 120.987 114.984 1.00 20.00  ? 412 OCT A H41  1 
HETATM 5014 H H42  . OCT BA 4 .   ? 100.173 119.838 116.165 1.00 20.00  ? 412 OCT A H42  1 
HETATM 5015 H H51  . OCT BA 4 .   ? 97.924  120.101 115.018 1.00 20.00  ? 412 OCT A H51  1 
HETATM 5016 H H52  . OCT BA 4 .   ? 99.173  119.250 114.108 1.00 20.00  ? 412 OCT A H52  1 
HETATM 5017 H H61  . OCT BA 4 .   ? 98.167  122.059 113.727 1.00 20.00  ? 412 OCT A H61  1 
HETATM 5018 H H62  . OCT BA 4 .   ? 99.706  121.518 113.051 1.00 20.00  ? 412 OCT A H62  1 
HETATM 5019 H H71  . OCT BA 4 .   ? 98.492  119.651 111.936 1.00 20.00  ? 412 OCT A H71  1 
HETATM 5020 H H72  . OCT BA 4 .   ? 96.976  120.341 112.519 1.00 20.00  ? 412 OCT A H72  1 
HETATM 5021 H H81  . OCT BA 4 .   ? 97.167  121.182 110.337 1.00 20.00  ? 412 OCT A H81  1 
HETATM 5022 H H82  . OCT BA 4 .   ? 97.754  122.507 111.351 1.00 20.00  ? 412 OCT A H82  1 
HETATM 5023 H H83  . OCT BA 4 .   ? 98.905  121.466 110.504 1.00 20.00  ? 412 OCT A H83  1 
HETATM 5024 C C1   . EIC CA 6 .   ? 120.501 106.781 113.267 1.00 20.00  ? 413 EIC A C1   1 
HETATM 5025 C C2   . EIC CA 6 .   ? 120.872 107.209 114.680 1.00 20.00  ? 413 EIC A C2   1 
HETATM 5026 C C3   . EIC CA 6 .   ? 120.275 108.546 115.156 1.00 20.00  ? 413 EIC A C3   1 
HETATM 5027 C C4   . EIC CA 6 .   ? 121.337 109.432 115.820 1.00 20.00  ? 413 EIC A C4   1 
HETATM 5028 C C5   . EIC CA 6 .   ? 120.915 109.869 117.219 1.00 20.00  ? 413 EIC A C5   1 
HETATM 5029 C C6   . EIC CA 6 .   ? 121.410 111.277 117.547 1.00 20.00  ? 413 EIC A C6   1 
HETATM 5030 C C7   . EIC CA 6 .   ? 122.042 111.331 118.947 1.00 20.00  ? 413 EIC A C7   1 
HETATM 5031 C C8   . EIC CA 6 .   ? 121.016 111.107 120.065 1.00 20.00  ? 413 EIC A C8   1 
HETATM 5032 C C9   . EIC CA 6 .   ? 121.385 111.957 121.253 1.00 20.00  ? 413 EIC A C9   1 
HETATM 5033 C C10  . EIC CA 6 .   ? 120.708 112.164 122.382 1.00 20.00  ? 413 EIC A C10  1 
HETATM 5034 C C11  . EIC CA 6 .   ? 119.375 111.615 122.826 1.00 20.00  ? 413 EIC A C11  1 
HETATM 5035 C C12  . EIC CA 6 .   ? 119.195 111.950 124.296 1.00 20.00  ? 413 EIC A C12  1 
HETATM 5036 C C13  . EIC CA 6 .   ? 118.856 111.154 125.322 1.00 20.00  ? 413 EIC A C13  1 
HETATM 5037 C C14  . EIC CA 6 .   ? 118.550 109.676 125.291 1.00 20.00  ? 413 EIC A C14  1 
HETATM 5038 C C15  . EIC CA 6 .   ? 118.720 109.058 126.682 1.00 20.00  ? 413 EIC A C15  1 
HETATM 5039 C C16  . EIC CA 6 .   ? 118.143 107.639 126.763 1.00 20.00  ? 413 EIC A C16  1 
HETATM 5040 C C17  . EIC CA 6 .   ? 119.203 106.580 126.455 1.00 20.00  ? 413 EIC A C17  1 
HETATM 5041 C C18  . EIC CA 6 .   ? 118.616 105.166 126.429 1.00 20.00  ? 413 EIC A C18  1 
HETATM 5042 O O1   . EIC CA 6 .   ? 121.376 106.683 112.435 1.00 20.00  ? 413 EIC A O1   1 
HETATM 5043 O O2   . EIC CA 6 .   ? 119.335 106.553 113.062 1.00 20.00  ? 413 EIC A O2   1 
HETATM 5044 H H21  . EIC CA 6 .   ? 121.967 107.255 114.724 1.00 20.00  ? 413 EIC A H21  1 
HETATM 5045 H H22  . EIC CA 6 .   ? 120.561 106.410 115.363 1.00 20.00  ? 413 EIC A H22  1 
HETATM 5046 H H31  . EIC CA 6 .   ? 119.457 108.344 115.859 1.00 20.00  ? 413 EIC A H31  1 
HETATM 5047 H H32  . EIC CA 6 .   ? 119.838 109.070 114.297 1.00 20.00  ? 413 EIC A H32  1 
HETATM 5048 H H41  . EIC CA 6 .   ? 121.515 110.315 115.201 1.00 20.00  ? 413 EIC A H41  1 
HETATM 5049 H H42  . EIC CA 6 .   ? 122.288 108.889 115.884 1.00 20.00  ? 413 EIC A H42  1 
HETATM 5050 H H51  . EIC CA 6 .   ? 121.340 109.166 117.941 1.00 20.00  ? 413 EIC A H51  1 
HETATM 5051 H H52  . EIC CA 6 .   ? 119.825 109.826 117.318 1.00 20.00  ? 413 EIC A H52  1 
HETATM 5052 H H61  . EIC CA 6 .   ? 120.567 111.980 117.494 1.00 20.00  ? 413 EIC A H61  1 
HETATM 5053 H H62  . EIC CA 6 .   ? 122.151 111.589 116.800 1.00 20.00  ? 413 EIC A H62  1 
HETATM 5054 H H71  . EIC CA 6 .   ? 122.520 112.310 119.075 1.00 20.00  ? 413 EIC A H71  1 
HETATM 5055 H H72  . EIC CA 6 .   ? 122.826 110.566 119.024 1.00 20.00  ? 413 EIC A H72  1 
HETATM 5056 H H81  . EIC CA 6 .   ? 121.022 110.052 120.357 1.00 20.00  ? 413 EIC A H81  1 
HETATM 5057 H H82  . EIC CA 6 .   ? 120.012 111.328 119.691 1.00 20.00  ? 413 EIC A H82  1 
HETATM 5058 H H91  . EIC CA 6 .   ? 122.344 112.460 121.141 1.00 20.00  ? 413 EIC A H91  1 
HETATM 5059 H H1O1 . EIC CA 6 .   ? 121.155 112.823 123.128 1.00 20.00  ? 413 EIC A H1O1 1 
HETATM 5060 H H111 . EIC CA 6 .   ? 119.319 110.530 122.695 1.00 20.00  ? 413 EIC A H111 1 
HETATM 5061 H H112 . EIC CA 6 .   ? 118.590 112.056 122.203 1.00 20.00  ? 413 EIC A H112 1 
HETATM 5062 H H121 . EIC CA 6 .   ? 119.381 113.002 124.512 1.00 20.00  ? 413 EIC A H121 1 
HETATM 5063 H H131 . EIC CA 6 .   ? 118.780 111.593 126.315 1.00 20.00  ? 413 EIC A H131 1 
HETATM 5064 H H141 . EIC CA 6 .   ? 119.193 109.141 124.584 1.00 20.00  ? 413 EIC A H141 1 
HETATM 5065 H H142 . EIC CA 6 .   ? 117.518 109.525 124.951 1.00 20.00  ? 413 EIC A H142 1 
HETATM 5066 H H151 . EIC CA 6 .   ? 118.231 109.703 127.422 1.00 20.00  ? 413 EIC A H151 1 
HETATM 5067 H H152 . EIC CA 6 .   ? 119.789 109.023 126.931 1.00 20.00  ? 413 EIC A H152 1 
HETATM 5068 H H161 . EIC CA 6 .   ? 117.316 107.541 126.047 1.00 20.00  ? 413 EIC A H161 1 
HETATM 5069 H H162 . EIC CA 6 .   ? 117.730 107.464 127.766 1.00 20.00  ? 413 EIC A H162 1 
HETATM 5070 H H171 . EIC CA 6 .   ? 119.997 106.630 127.210 1.00 20.00  ? 413 EIC A H171 1 
HETATM 5071 H H172 . EIC CA 6 .   ? 119.664 106.793 125.484 1.00 20.00  ? 413 EIC A H172 1 
HETATM 5072 H H181 . EIC CA 6 .   ? 118.672 104.747 125.418 1.00 20.00  ? 413 EIC A H181 1 
HETATM 5073 H H182 . EIC CA 6 .   ? 119.162 104.502 127.111 1.00 20.00  ? 413 EIC A H182 1 
HETATM 5074 H H183 . EIC CA 6 .   ? 117.560 105.181 126.733 1.00 20.00  ? 413 EIC A H183 1 
HETATM 5075 C C1   . D12 DA 3 .   ? 145.799 131.794 138.565 1.00 20.00  ? 414 D12 A C1   1 
HETATM 5076 C C2   . D12 DA 3 .   ? 145.580 132.109 137.083 1.00 20.00  ? 414 D12 A C2   1 
HETATM 5077 C C3   . D12 DA 3 .   ? 144.179 132.639 136.770 1.00 20.00  ? 414 D12 A C3   1 
HETATM 5078 C C4   . D12 DA 3 .   ? 144.151 133.529 135.524 1.00 20.00  ? 414 D12 A C4   1 
HETATM 5079 C C5   . D12 DA 3 .   ? 143.414 132.911 134.336 1.00 20.00  ? 414 D12 A C5   1 
HETATM 5080 C C6   . D12 DA 3 .   ? 141.952 133.349 134.271 1.00 20.00  ? 414 D12 A C6   1 
HETATM 5081 C C7   . D12 DA 3 .   ? 141.134 132.547 133.256 1.00 20.00  ? 414 D12 A C7   1 
HETATM 5082 C C8   . D12 DA 3 .   ? 141.120 133.166 131.858 1.00 20.00  ? 414 D12 A C8   1 
HETATM 5083 C C9   . D12 DA 3 .   ? 139.742 133.117 131.213 1.00 20.00  ? 414 D12 A C9   1 
HETATM 5084 C C10  . D12 DA 3 .   ? 139.791 133.495 129.736 1.00 20.00  ? 414 D12 A C10  1 
HETATM 5085 C C11  . D12 DA 3 .   ? 138.506 133.131 128.997 1.00 20.00  ? 414 D12 A C11  1 
HETATM 5086 C C12  . D12 DA 3 .   ? 137.494 134.272 129.021 1.00 20.00  ? 414 D12 A C12  1 
HETATM 5087 H H11  . D12 DA 3 .   ? 146.452 132.544 139.002 1.00 20.00  ? 414 D12 A H11  1 
HETATM 5088 H H12  . D12 DA 3 .   ? 146.253 130.813 138.665 1.00 20.00  ? 414 D12 A H12  1 
HETATM 5089 H H13  . D12 DA 3 .   ? 144.842 131.807 139.079 1.00 20.00  ? 414 D12 A H13  1 
HETATM 5090 H H21  . D12 DA 3 .   ? 145.742 131.204 136.508 1.00 20.00  ? 414 D12 A H21  1 
HETATM 5091 H H22  . D12 DA 3 .   ? 146.310 132.851 136.779 1.00 20.00  ? 414 D12 A H22  1 
HETATM 5092 H H31  . D12 DA 3 .   ? 143.827 133.218 137.617 1.00 20.00  ? 414 D12 A H31  1 
HETATM 5093 H H32  . D12 DA 3 .   ? 143.509 131.799 136.617 1.00 20.00  ? 414 D12 A H32  1 
HETATM 5094 H H41  . D12 DA 3 .   ? 145.171 133.740 135.224 1.00 20.00  ? 414 D12 A H41  1 
HETATM 5095 H H42  . D12 DA 3 .   ? 143.663 134.462 135.778 1.00 20.00  ? 414 D12 A H42  1 
HETATM 5096 H H51  . D12 DA 3 .   ? 143.455 131.831 134.420 1.00 20.00  ? 414 D12 A H51  1 
HETATM 5097 H H52  . D12 DA 3 .   ? 143.908 133.214 133.419 1.00 20.00  ? 414 D12 A H52  1 
HETATM 5098 H H61  . D12 DA 3 .   ? 141.510 133.219 135.254 1.00 20.00  ? 414 D12 A H61  1 
HETATM 5099 H H62  . D12 DA 3 .   ? 141.914 134.400 134.010 1.00 20.00  ? 414 D12 A H62  1 
HETATM 5100 H H71  . D12 DA 3 .   ? 141.551 131.548 133.189 1.00 20.00  ? 414 D12 A H71  1 
HETATM 5101 H H72  . D12 DA 3 .   ? 140.112 132.476 133.613 1.00 20.00  ? 414 D12 A H72  1 
HETATM 5102 H H81  . D12 DA 3 .   ? 141.818 132.626 131.228 1.00 20.00  ? 414 D12 A H81  1 
HETATM 5103 H H82  . D12 DA 3 .   ? 141.434 134.201 131.925 1.00 20.00  ? 414 D12 A H82  1 
HETATM 5104 H H91  . D12 DA 3 .   ? 139.087 133.808 131.732 1.00 20.00  ? 414 D12 A H91  1 
HETATM 5105 H H92  . D12 DA 3 .   ? 139.345 132.113 131.309 1.00 20.00  ? 414 D12 A H92  1 
HETATM 5106 H H101 . D12 DA 3 .   ? 139.948 134.565 129.654 1.00 20.00  ? 414 D12 A H101 1 
HETATM 5107 H H102 . D12 DA 3 .   ? 140.622 132.979 129.269 1.00 20.00  ? 414 D12 A H102 1 
HETATM 5108 H H111 . D12 DA 3 .   ? 138.066 132.259 129.466 1.00 20.00  ? 414 D12 A H111 1 
HETATM 5109 H H112 . D12 DA 3 .   ? 138.746 132.896 127.965 1.00 20.00  ? 414 D12 A H112 1 
HETATM 5110 H H121 . D12 DA 3 .   ? 137.583 134.812 129.959 1.00 20.00  ? 414 D12 A H121 1 
HETATM 5111 H H122 . D12 DA 3 .   ? 137.691 134.949 128.194 1.00 20.00  ? 414 D12 A H122 1 
HETATM 5112 H H123 . D12 DA 3 .   ? 136.490 133.869 128.928 1.00 20.00  ? 414 D12 A H123 1 
HETATM 5113 K K    . K   EA 7 .   ? 123.807 123.857 117.918 1.00 79.16  ? 415 K   A K    1 
HETATM 5114 K K    . K   FA 7 .   ? 123.811 123.856 121.252 1.00 88.29  ? 416 K   A K    1 
HETATM 5115 K K    . K   GA 7 .   ? 123.847 123.904 111.830 1.00 30.00  ? 417 K   A K    1 
# 
