data_9BWS
# 
_entry.id   9BWS 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BWS         pdb_00009bws 10.2210/pdb9bws/pdb 
WWPDB D_1000284173 ?            ?                   
EMDB  EMD-44978    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-26 ? 
2 'EM metadata'     1 0 2025-02-26 ? 
3 'Half map'        1 0 2025-02-26 1 
4 'Half map'        1 0 2025-02-26 2 
5 Image             1 0 2025-02-26 ? 
6 'Primary map'     1 0 2025-02-26 ? 
7 'Structure model' 1 1 2025-03-12 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 'Half map'        repository 'Initial release' ? ? 
4 4 'Half map'        repository 'Initial release' ? ? 
5 5 Image             repository 'Initial release' ? ? 
6 6 'Primary map'     repository 'Initial release' ? ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 7 'Structure model' 'Data collection'     
2 7 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 7 'Structure model' citation        
2 7 'Structure model' citation_author 
3 7 'Structure model' em_admin        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 7 'Structure model' '_citation.country'                 
2 7 'Structure model' '_citation.journal_abbrev'          
3 7 'Structure model' '_citation.journal_id_CSD'          
4 7 'Structure model' '_citation.journal_id_ISSN'         
5 7 'Structure model' '_citation.pdbx_database_id_DOI'    
6 7 'Structure model' '_citation.pdbx_database_id_PubMed' 
7 7 'Structure model' '_citation.title'                   
8 7 'Structure model' '_citation.year'                    
9 7 'Structure model' '_em_admin.last_update'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BWS 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-21 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB  'k2P13.1 (THIK-1) without activating mutations, nanodisc'           9BSN      unspecified            
EMDB 'Structure of human k2P13.1 (THIK-1) Y273A S136P in lipid nanodisc' EMD-44978 'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              daniel.minor@ucsf.edu 
_pdbx_contact_author.name_first         Daniel 
_pdbx_contact_author.name_last          Minor 
_pdbx_contact_author.name_mi            L. 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-5998-4214 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Roy-Chowdhury, S.' 1 0000-0001-7128-7668 
'Minor, D.L.'       2 0000-0002-5998-4214 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Nat.Struct.Mol.Biol. 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1545-9985 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Structure of the human K 2P 13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41594-024-01476-3 
_citation.pdbx_database_id_PubMed   40011746 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Roy-Chowdhury, S.'  1 ?                   
primary 'Jang, S.'           2 ?                   
primary 'Abderemane-Ali, F.' 3 0000-0002-7097-1684 
primary 'Naughton, F.'       4 0000-0003-0162-1346 
primary 'Grabe, M.'          5 0000-0003-3509-5997 
primary 'Minor Jr., D.L.'    6 0000-0002-5998-4214 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Potassium channel subfamily K member 13' 39291.520 2 ? 'N59Q N65Q S136P Y273A' ? ? 
2 non-polymer syn DODECANE                                  170.335   2 ? ?                       ? ? 
3 non-polymer syn DECANE                                    142.282   4 ? ?                       ? ? 
4 non-polymer syn N-OCTANE                                  114.229   8 ? ?                       ? ? 
5 non-polymer syn HEXANE                                    86.175    2 ? ?                       ? ? 
6 non-polymer syn 'LINOLEIC ACID'                           280.445   2 ? ?                       ? ? 
7 non-polymer syn 'POTASSIUM ION'                           39.098    4 ? ?                       ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Tandem pore domain halothane-inhibited potassium channel 1,THIK-1' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MAGRGFSWGPGHLNEDNARFLLLAALIVLYLLGGAAVFSALELAHERQAKQRWEERLAQFSRGHQLSRDELRGFLRHYEE
ATRAGIRVDNVRPRWDFTGAFYFVGTVVSTIGFGMTTPATVGGKIFLIFYGLVGCPSTILFFNLFLERLITIIAYIMKSC
HQRQLRRRGALPQESLKDAGQCEVDSLAGWKPSVYYVMLILCTASILISCCASAMYTPIEGWSYFDSLYFCFVAFSTIGF
GDLVSSQNAHYESQGLYRFANFVFILMGVCCIASLFNVISILIKQSLNWILRKMDSGCCPQCQRGLLRSRRNVVMPGSVR
NRCNISIETDGVAESDTDGRRLSGEMISMK
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MAGRGFSWGPGHLNEDNARFLLLAALIVLYLLGGAAVFSALELAHERQAKQRWEERLAQFSRGHQLSRDELRGFLRHYEE
ATRAGIRVDNVRPRWDFTGAFYFVGTVVSTIGFGMTTPATVGGKIFLIFYGLVGCPSTILFFNLFLERLITIIAYIMKSC
HQRQLRRRGALPQESLKDAGQCEVDSLAGWKPSVYYVMLILCTASILISCCASAMYTPIEGWSYFDSLYFCFVAFSTIGF
GDLVSSQNAHYESQGLYRFANFVFILMGVCCIASLFNVISILIKQSLNWILRKMDSGCCPQCQRGLLRSRRNVVMPGSVR
NRCNISIETDGVAESDTDGRRLSGEMISMK
;
_entity_poly.pdbx_strand_id                 U,A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 DODECANE        D12 
3 DECANE          D10 
4 N-OCTANE        OCT 
5 HEXANE          HEX 
6 'LINOLEIC ACID' EIC 
7 'POTASSIUM ION' K   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   GLY n 
1 4   ARG n 
1 5   GLY n 
1 6   PHE n 
1 7   SER n 
1 8   TRP n 
1 9   GLY n 
1 10  PRO n 
1 11  GLY n 
1 12  HIS n 
1 13  LEU n 
1 14  ASN n 
1 15  GLU n 
1 16  ASP n 
1 17  ASN n 
1 18  ALA n 
1 19  ARG n 
1 20  PHE n 
1 21  LEU n 
1 22  LEU n 
1 23  LEU n 
1 24  ALA n 
1 25  ALA n 
1 26  LEU n 
1 27  ILE n 
1 28  VAL n 
1 29  LEU n 
1 30  TYR n 
1 31  LEU n 
1 32  LEU n 
1 33  GLY n 
1 34  GLY n 
1 35  ALA n 
1 36  ALA n 
1 37  VAL n 
1 38  PHE n 
1 39  SER n 
1 40  ALA n 
1 41  LEU n 
1 42  GLU n 
1 43  LEU n 
1 44  ALA n 
1 45  HIS n 
1 46  GLU n 
1 47  ARG n 
1 48  GLN n 
1 49  ALA n 
1 50  LYS n 
1 51  GLN n 
1 52  ARG n 
1 53  TRP n 
1 54  GLU n 
1 55  GLU n 
1 56  ARG n 
1 57  LEU n 
1 58  ALA n 
1 59  GLN n 
1 60  PHE n 
1 61  SER n 
1 62  ARG n 
1 63  GLY n 
1 64  HIS n 
1 65  GLN n 
1 66  LEU n 
1 67  SER n 
1 68  ARG n 
1 69  ASP n 
1 70  GLU n 
1 71  LEU n 
1 72  ARG n 
1 73  GLY n 
1 74  PHE n 
1 75  LEU n 
1 76  ARG n 
1 77  HIS n 
1 78  TYR n 
1 79  GLU n 
1 80  GLU n 
1 81  ALA n 
1 82  THR n 
1 83  ARG n 
1 84  ALA n 
1 85  GLY n 
1 86  ILE n 
1 87  ARG n 
1 88  VAL n 
1 89  ASP n 
1 90  ASN n 
1 91  VAL n 
1 92  ARG n 
1 93  PRO n 
1 94  ARG n 
1 95  TRP n 
1 96  ASP n 
1 97  PHE n 
1 98  THR n 
1 99  GLY n 
1 100 ALA n 
1 101 PHE n 
1 102 TYR n 
1 103 PHE n 
1 104 VAL n 
1 105 GLY n 
1 106 THR n 
1 107 VAL n 
1 108 VAL n 
1 109 SER n 
1 110 THR n 
1 111 ILE n 
1 112 GLY n 
1 113 PHE n 
1 114 GLY n 
1 115 MET n 
1 116 THR n 
1 117 THR n 
1 118 PRO n 
1 119 ALA n 
1 120 THR n 
1 121 VAL n 
1 122 GLY n 
1 123 GLY n 
1 124 LYS n 
1 125 ILE n 
1 126 PHE n 
1 127 LEU n 
1 128 ILE n 
1 129 PHE n 
1 130 TYR n 
1 131 GLY n 
1 132 LEU n 
1 133 VAL n 
1 134 GLY n 
1 135 CYS n 
1 136 PRO n 
1 137 SER n 
1 138 THR n 
1 139 ILE n 
1 140 LEU n 
1 141 PHE n 
1 142 PHE n 
1 143 ASN n 
1 144 LEU n 
1 145 PHE n 
1 146 LEU n 
1 147 GLU n 
1 148 ARG n 
1 149 LEU n 
1 150 ILE n 
1 151 THR n 
1 152 ILE n 
1 153 ILE n 
1 154 ALA n 
1 155 TYR n 
1 156 ILE n 
1 157 MET n 
1 158 LYS n 
1 159 SER n 
1 160 CYS n 
1 161 HIS n 
1 162 GLN n 
1 163 ARG n 
1 164 GLN n 
1 165 LEU n 
1 166 ARG n 
1 167 ARG n 
1 168 ARG n 
1 169 GLY n 
1 170 ALA n 
1 171 LEU n 
1 172 PRO n 
1 173 GLN n 
1 174 GLU n 
1 175 SER n 
1 176 LEU n 
1 177 LYS n 
1 178 ASP n 
1 179 ALA n 
1 180 GLY n 
1 181 GLN n 
1 182 CYS n 
1 183 GLU n 
1 184 VAL n 
1 185 ASP n 
1 186 SER n 
1 187 LEU n 
1 188 ALA n 
1 189 GLY n 
1 190 TRP n 
1 191 LYS n 
1 192 PRO n 
1 193 SER n 
1 194 VAL n 
1 195 TYR n 
1 196 TYR n 
1 197 VAL n 
1 198 MET n 
1 199 LEU n 
1 200 ILE n 
1 201 LEU n 
1 202 CYS n 
1 203 THR n 
1 204 ALA n 
1 205 SER n 
1 206 ILE n 
1 207 LEU n 
1 208 ILE n 
1 209 SER n 
1 210 CYS n 
1 211 CYS n 
1 212 ALA n 
1 213 SER n 
1 214 ALA n 
1 215 MET n 
1 216 TYR n 
1 217 THR n 
1 218 PRO n 
1 219 ILE n 
1 220 GLU n 
1 221 GLY n 
1 222 TRP n 
1 223 SER n 
1 224 TYR n 
1 225 PHE n 
1 226 ASP n 
1 227 SER n 
1 228 LEU n 
1 229 TYR n 
1 230 PHE n 
1 231 CYS n 
1 232 PHE n 
1 233 VAL n 
1 234 ALA n 
1 235 PHE n 
1 236 SER n 
1 237 THR n 
1 238 ILE n 
1 239 GLY n 
1 240 PHE n 
1 241 GLY n 
1 242 ASP n 
1 243 LEU n 
1 244 VAL n 
1 245 SER n 
1 246 SER n 
1 247 GLN n 
1 248 ASN n 
1 249 ALA n 
1 250 HIS n 
1 251 TYR n 
1 252 GLU n 
1 253 SER n 
1 254 GLN n 
1 255 GLY n 
1 256 LEU n 
1 257 TYR n 
1 258 ARG n 
1 259 PHE n 
1 260 ALA n 
1 261 ASN n 
1 262 PHE n 
1 263 VAL n 
1 264 PHE n 
1 265 ILE n 
1 266 LEU n 
1 267 MET n 
1 268 GLY n 
1 269 VAL n 
1 270 CYS n 
1 271 CYS n 
1 272 ILE n 
1 273 ALA n 
1 274 SER n 
1 275 LEU n 
1 276 PHE n 
1 277 ASN n 
1 278 VAL n 
1 279 ILE n 
1 280 SER n 
1 281 ILE n 
1 282 LEU n 
1 283 ILE n 
1 284 LYS n 
1 285 GLN n 
1 286 SER n 
1 287 LEU n 
1 288 ASN n 
1 289 TRP n 
1 290 ILE n 
1 291 LEU n 
1 292 ARG n 
1 293 LYS n 
1 294 MET n 
1 295 ASP n 
1 296 SER n 
1 297 GLY n 
1 298 CYS n 
1 299 CYS n 
1 300 PRO n 
1 301 GLN n 
1 302 CYS n 
1 303 GLN n 
1 304 ARG n 
1 305 GLY n 
1 306 LEU n 
1 307 LEU n 
1 308 ARG n 
1 309 SER n 
1 310 ARG n 
1 311 ARG n 
1 312 ASN n 
1 313 VAL n 
1 314 VAL n 
1 315 MET n 
1 316 PRO n 
1 317 GLY n 
1 318 SER n 
1 319 VAL n 
1 320 ARG n 
1 321 ASN n 
1 322 ARG n 
1 323 CYS n 
1 324 ASN n 
1 325 ILE n 
1 326 SER n 
1 327 ILE n 
1 328 GLU n 
1 329 THR n 
1 330 ASP n 
1 331 GLY n 
1 332 VAL n 
1 333 ALA n 
1 334 GLU n 
1 335 SER n 
1 336 ASP n 
1 337 THR n 
1 338 ASP n 
1 339 GLY n 
1 340 ARG n 
1 341 ARG n 
1 342 LEU n 
1 343 SER n 
1 344 GLY n 
1 345 GLU n 
1 346 MET n 
1 347 ILE n 
1 348 SER n 
1 349 MET n 
1 350 LYS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   350 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 KCNK13 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               human 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ?                    'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ?                    'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ?                    'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                    'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ?                    'C3 H7 N O2 S'   121.158 
D10 non-polymer         . DECANE          ?                    'C10 H22'        142.282 
D12 non-polymer         . DODECANE        ?                    'C12 H26'        170.335 
EIC non-polymer         . 'LINOLEIC ACID' '9,12-LINOLEIC ACID' 'C18 H32 O2'     280.445 
GLN 'L-peptide linking' y GLUTAMINE       ?                    'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                    'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ?                    'C2 H5 N O2'     75.067  
HEX non-polymer         . HEXANE          ?                    'C6 H14'         86.175  
HIS 'L-peptide linking' y HISTIDINE       ?                    'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ?                    'C6 H13 N O2'    131.173 
K   non-polymer         . 'POTASSIUM ION' ?                    'K 1'            39.098  
LEU 'L-peptide linking' y LEUCINE         ?                    'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ?                    'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ?                    'C5 H11 N O2 S'  149.211 
OCT non-polymer         . N-OCTANE        ?                    'C8 H18'         114.229 
PHE 'L-peptide linking' y PHENYLALANINE   ?                    'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ?                    'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ?                    'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ?                    'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ?                    'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ?                    'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ?                    'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   U . n 
A 1 2   ALA 2   2   ?   ?   ?   U . n 
A 1 3   GLY 3   3   ?   ?   ?   U . n 
A 1 4   ARG 4   4   ?   ?   ?   U . n 
A 1 5   GLY 5   5   ?   ?   ?   U . n 
A 1 6   PHE 6   6   ?   ?   ?   U . n 
A 1 7   SER 7   7   ?   ?   ?   U . n 
A 1 8   TRP 8   8   ?   ?   ?   U . n 
A 1 9   GLY 9   9   ?   ?   ?   U . n 
A 1 10  PRO 10  10  ?   ?   ?   U . n 
A 1 11  GLY 11  11  ?   ?   ?   U . n 
A 1 12  HIS 12  12  ?   ?   ?   U . n 
A 1 13  LEU 13  13  ?   ?   ?   U . n 
A 1 14  ASN 14  14  14  ASN ASN U . n 
A 1 15  GLU 15  15  15  GLU GLU U . n 
A 1 16  ASP 16  16  16  ASP ASP U . n 
A 1 17  ASN 17  17  17  ASN ASN U . n 
A 1 18  ALA 18  18  18  ALA ALA U . n 
A 1 19  ARG 19  19  19  ARG ARG U . n 
A 1 20  PHE 20  20  20  PHE PHE U . n 
A 1 21  LEU 21  21  21  LEU LEU U . n 
A 1 22  LEU 22  22  22  LEU LEU U . n 
A 1 23  LEU 23  23  23  LEU LEU U . n 
A 1 24  ALA 24  24  24  ALA ALA U . n 
A 1 25  ALA 25  25  25  ALA ALA U . n 
A 1 26  LEU 26  26  26  LEU LEU U . n 
A 1 27  ILE 27  27  27  ILE ILE U . n 
A 1 28  VAL 28  28  28  VAL VAL U . n 
A 1 29  LEU 29  29  29  LEU LEU U . n 
A 1 30  TYR 30  30  30  TYR TYR U . n 
A 1 31  LEU 31  31  31  LEU LEU U . n 
A 1 32  LEU 32  32  32  LEU LEU U . n 
A 1 33  GLY 33  33  33  GLY GLY U . n 
A 1 34  GLY 34  34  34  GLY GLY U . n 
A 1 35  ALA 35  35  35  ALA ALA U . n 
A 1 36  ALA 36  36  36  ALA ALA U . n 
A 1 37  VAL 37  37  37  VAL VAL U . n 
A 1 38  PHE 38  38  38  PHE PHE U . n 
A 1 39  SER 39  39  39  SER SER U . n 
A 1 40  ALA 40  40  40  ALA ALA U . n 
A 1 41  LEU 41  41  41  LEU LEU U . n 
A 1 42  GLU 42  42  42  GLU GLU U . n 
A 1 43  LEU 43  43  43  LEU LEU U . n 
A 1 44  ALA 44  44  44  ALA ALA U . n 
A 1 45  HIS 45  45  45  HIS HIS U . n 
A 1 46  GLU 46  46  46  GLU GLU U . n 
A 1 47  ARG 47  47  47  ARG ARG U . n 
A 1 48  GLN 48  48  48  GLN GLN U . n 
A 1 49  ALA 49  49  49  ALA ALA U . n 
A 1 50  LYS 50  50  50  LYS LYS U . n 
A 1 51  GLN 51  51  51  GLN GLN U . n 
A 1 52  ARG 52  52  52  ARG ARG U . n 
A 1 53  TRP 53  53  53  TRP TRP U . n 
A 1 54  GLU 54  54  54  GLU GLU U . n 
A 1 55  GLU 55  55  55  GLU GLU U . n 
A 1 56  ARG 56  56  56  ARG ARG U . n 
A 1 57  LEU 57  57  57  LEU LEU U . n 
A 1 58  ALA 58  58  58  ALA ALA U . n 
A 1 59  GLN 59  59  59  GLN GLN U . n 
A 1 60  PHE 60  60  60  PHE PHE U . n 
A 1 61  SER 61  61  61  SER SER U . n 
A 1 62  ARG 62  62  62  ARG ARG U . n 
A 1 63  GLY 63  63  63  GLY GLY U . n 
A 1 64  HIS 64  64  64  HIS HIS U . n 
A 1 65  GLN 65  65  65  GLN GLN U . n 
A 1 66  LEU 66  66  66  LEU LEU U . n 
A 1 67  SER 67  67  67  SER SER U . n 
A 1 68  ARG 68  68  68  ARG ARG U . n 
A 1 69  ASP 69  69  69  ASP ASP U . n 
A 1 70  GLU 70  70  70  GLU GLU U . n 
A 1 71  LEU 71  71  71  LEU LEU U . n 
A 1 72  ARG 72  72  72  ARG ARG U . n 
A 1 73  GLY 73  73  73  GLY GLY U . n 
A 1 74  PHE 74  74  74  PHE PHE U . n 
A 1 75  LEU 75  75  75  LEU LEU U . n 
A 1 76  ARG 76  76  76  ARG ARG U . n 
A 1 77  HIS 77  77  77  HIS HIS U . n 
A 1 78  TYR 78  78  78  TYR TYR U . n 
A 1 79  GLU 79  79  79  GLU GLU U . n 
A 1 80  GLU 80  80  80  GLU GLU U . n 
A 1 81  ALA 81  81  81  ALA ALA U . n 
A 1 82  THR 82  82  82  THR THR U . n 
A 1 83  ARG 83  83  83  ARG ARG U . n 
A 1 84  ALA 84  84  84  ALA ALA U . n 
A 1 85  GLY 85  85  85  GLY GLY U . n 
A 1 86  ILE 86  86  86  ILE ILE U . n 
A 1 87  ARG 87  87  87  ARG ARG U . n 
A 1 88  VAL 88  88  88  VAL VAL U . n 
A 1 89  ASP 89  89  89  ASP ASP U . n 
A 1 90  ASN 90  90  90  ASN ASN U . n 
A 1 91  VAL 91  91  91  VAL VAL U . n 
A 1 92  ARG 92  92  92  ARG ARG U . n 
A 1 93  PRO 93  93  93  PRO PRO U . n 
A 1 94  ARG 94  94  94  ARG ARG U . n 
A 1 95  TRP 95  95  95  TRP TRP U . n 
A 1 96  ASP 96  96  96  ASP ASP U . n 
A 1 97  PHE 97  97  97  PHE PHE U . n 
A 1 98  THR 98  98  98  THR THR U . n 
A 1 99  GLY 99  99  99  GLY GLY U . n 
A 1 100 ALA 100 100 100 ALA ALA U . n 
A 1 101 PHE 101 101 101 PHE PHE U . n 
A 1 102 TYR 102 102 102 TYR TYR U . n 
A 1 103 PHE 103 103 103 PHE PHE U . n 
A 1 104 VAL 104 104 104 VAL VAL U . n 
A 1 105 GLY 105 105 105 GLY GLY U . n 
A 1 106 THR 106 106 106 THR THR U . n 
A 1 107 VAL 107 107 107 VAL VAL U . n 
A 1 108 VAL 108 108 108 VAL VAL U . n 
A 1 109 SER 109 109 109 SER SER U . n 
A 1 110 THR 110 110 110 THR THR U . n 
A 1 111 ILE 111 111 111 ILE ILE U . n 
A 1 112 GLY 112 112 112 GLY GLY U . n 
A 1 113 PHE 113 113 113 PHE PHE U . n 
A 1 114 GLY 114 114 114 GLY GLY U . n 
A 1 115 MET 115 115 115 MET MET U . n 
A 1 116 THR 116 116 116 THR THR U . n 
A 1 117 THR 117 117 117 THR THR U . n 
A 1 118 PRO 118 118 118 PRO PRO U . n 
A 1 119 ALA 119 119 119 ALA ALA U . n 
A 1 120 THR 120 120 120 THR THR U . n 
A 1 121 VAL 121 121 121 VAL VAL U . n 
A 1 122 GLY 122 122 122 GLY GLY U . n 
A 1 123 GLY 123 123 123 GLY GLY U . n 
A 1 124 LYS 124 124 124 LYS LYS U . n 
A 1 125 ILE 125 125 125 ILE ILE U . n 
A 1 126 PHE 126 126 126 PHE PHE U . n 
A 1 127 LEU 127 127 127 LEU LEU U . n 
A 1 128 ILE 128 128 128 ILE ILE U . n 
A 1 129 PHE 129 129 129 PHE PHE U . n 
A 1 130 TYR 130 130 130 TYR TYR U . n 
A 1 131 GLY 131 131 131 GLY GLY U . n 
A 1 132 LEU 132 132 132 LEU LEU U . n 
A 1 133 VAL 133 133 133 VAL VAL U . n 
A 1 134 GLY 134 134 134 GLY GLY U . n 
A 1 135 CYS 135 135 135 CYS CYS U . n 
A 1 136 PRO 136 136 136 PRO PRO U . n 
A 1 137 SER 137 137 137 SER SER U . n 
A 1 138 THR 138 138 138 THR THR U . n 
A 1 139 ILE 139 139 139 ILE ILE U . n 
A 1 140 LEU 140 140 140 LEU LEU U . n 
A 1 141 PHE 141 141 141 PHE PHE U . n 
A 1 142 PHE 142 142 142 PHE PHE U . n 
A 1 143 ASN 143 143 143 ASN ASN U . n 
A 1 144 LEU 144 144 144 LEU LEU U . n 
A 1 145 PHE 145 145 145 PHE PHE U . n 
A 1 146 LEU 146 146 146 LEU LEU U . n 
A 1 147 GLU 147 147 147 GLU GLU U . n 
A 1 148 ARG 148 148 148 ARG ARG U . n 
A 1 149 LEU 149 149 149 LEU LEU U . n 
A 1 150 ILE 150 150 150 ILE ILE U . n 
A 1 151 THR 151 151 151 THR THR U . n 
A 1 152 ILE 152 152 152 ILE ILE U . n 
A 1 153 ILE 153 153 153 ILE ILE U . n 
A 1 154 ALA 154 154 154 ALA ALA U . n 
A 1 155 TYR 155 155 155 TYR TYR U . n 
A 1 156 ILE 156 156 156 ILE ILE U . n 
A 1 157 MET 157 157 157 MET MET U . n 
A 1 158 LYS 158 158 158 LYS LYS U . n 
A 1 159 SER 159 159 159 SER SER U . n 
A 1 160 CYS 160 160 160 CYS CYS U . n 
A 1 161 HIS 161 161 161 HIS HIS U . n 
A 1 162 GLN 162 162 162 GLN GLN U . n 
A 1 163 ARG 163 163 ?   ?   ?   U . n 
A 1 164 GLN 164 164 ?   ?   ?   U . n 
A 1 165 LEU 165 165 ?   ?   ?   U . n 
A 1 166 ARG 166 166 ?   ?   ?   U . n 
A 1 167 ARG 167 167 ?   ?   ?   U . n 
A 1 168 ARG 168 168 ?   ?   ?   U . n 
A 1 169 GLY 169 169 ?   ?   ?   U . n 
A 1 170 ALA 170 170 ?   ?   ?   U . n 
A 1 171 LEU 171 171 ?   ?   ?   U . n 
A 1 172 PRO 172 172 ?   ?   ?   U . n 
A 1 173 GLN 173 173 ?   ?   ?   U . n 
A 1 174 GLU 174 174 ?   ?   ?   U . n 
A 1 175 SER 175 175 ?   ?   ?   U . n 
A 1 176 LEU 176 176 ?   ?   ?   U . n 
A 1 177 LYS 177 177 ?   ?   ?   U . n 
A 1 178 ASP 178 178 ?   ?   ?   U . n 
A 1 179 ALA 179 179 ?   ?   ?   U . n 
A 1 180 GLY 180 180 ?   ?   ?   U . n 
A 1 181 GLN 181 181 ?   ?   ?   U . n 
A 1 182 CYS 182 182 ?   ?   ?   U . n 
A 1 183 GLU 183 183 ?   ?   ?   U . n 
A 1 184 VAL 184 184 ?   ?   ?   U . n 
A 1 185 ASP 185 185 ?   ?   ?   U . n 
A 1 186 SER 186 186 ?   ?   ?   U . n 
A 1 187 LEU 187 187 ?   ?   ?   U . n 
A 1 188 ALA 188 188 188 ALA ALA U . n 
A 1 189 GLY 189 189 189 GLY GLY U . n 
A 1 190 TRP 190 190 190 TRP TRP U . n 
A 1 191 LYS 191 191 191 LYS LYS U . n 
A 1 192 PRO 192 192 192 PRO PRO U . n 
A 1 193 SER 193 193 193 SER SER U . n 
A 1 194 VAL 194 194 194 VAL VAL U . n 
A 1 195 TYR 195 195 195 TYR TYR U . n 
A 1 196 TYR 196 196 196 TYR TYR U . n 
A 1 197 VAL 197 197 197 VAL VAL U . n 
A 1 198 MET 198 198 198 MET MET U . n 
A 1 199 LEU 199 199 199 LEU LEU U . n 
A 1 200 ILE 200 200 200 ILE ILE U . n 
A 1 201 LEU 201 201 201 LEU LEU U . n 
A 1 202 CYS 202 202 202 CYS CYS U . n 
A 1 203 THR 203 203 203 THR THR U . n 
A 1 204 ALA 204 204 204 ALA ALA U . n 
A 1 205 SER 205 205 205 SER SER U . n 
A 1 206 ILE 206 206 206 ILE ILE U . n 
A 1 207 LEU 207 207 207 LEU LEU U . n 
A 1 208 ILE 208 208 208 ILE ILE U . n 
A 1 209 SER 209 209 209 SER SER U . n 
A 1 210 CYS 210 210 210 CYS CYS U . n 
A 1 211 CYS 211 211 211 CYS CYS U . n 
A 1 212 ALA 212 212 212 ALA ALA U . n 
A 1 213 SER 213 213 213 SER SER U . n 
A 1 214 ALA 214 214 214 ALA ALA U . n 
A 1 215 MET 215 215 215 MET MET U . n 
A 1 216 TYR 216 216 216 TYR TYR U . n 
A 1 217 THR 217 217 217 THR THR U . n 
A 1 218 PRO 218 218 218 PRO PRO U . n 
A 1 219 ILE 219 219 219 ILE ILE U . n 
A 1 220 GLU 220 220 220 GLU GLU U . n 
A 1 221 GLY 221 221 221 GLY GLY U . n 
A 1 222 TRP 222 222 222 TRP TRP U . n 
A 1 223 SER 223 223 223 SER SER U . n 
A 1 224 TYR 224 224 224 TYR TYR U . n 
A 1 225 PHE 225 225 225 PHE PHE U . n 
A 1 226 ASP 226 226 226 ASP ASP U . n 
A 1 227 SER 227 227 227 SER SER U . n 
A 1 228 LEU 228 228 228 LEU LEU U . n 
A 1 229 TYR 229 229 229 TYR TYR U . n 
A 1 230 PHE 230 230 230 PHE PHE U . n 
A 1 231 CYS 231 231 231 CYS CYS U . n 
A 1 232 PHE 232 232 232 PHE PHE U . n 
A 1 233 VAL 233 233 233 VAL VAL U . n 
A 1 234 ALA 234 234 234 ALA ALA U . n 
A 1 235 PHE 235 235 235 PHE PHE U . n 
A 1 236 SER 236 236 236 SER SER U . n 
A 1 237 THR 237 237 237 THR THR U . n 
A 1 238 ILE 238 238 238 ILE ILE U . n 
A 1 239 GLY 239 239 239 GLY GLY U . n 
A 1 240 PHE 240 240 240 PHE PHE U . n 
A 1 241 GLY 241 241 241 GLY GLY U . n 
A 1 242 ASP 242 242 242 ASP ASP U . n 
A 1 243 LEU 243 243 243 LEU LEU U . n 
A 1 244 VAL 244 244 244 VAL VAL U . n 
A 1 245 SER 245 245 245 SER SER U . n 
A 1 246 SER 246 246 246 SER SER U . n 
A 1 247 GLN 247 247 247 GLN GLN U . n 
A 1 248 ASN 248 248 248 ASN ASN U . n 
A 1 249 ALA 249 249 249 ALA ALA U . n 
A 1 250 HIS 250 250 250 HIS HIS U . n 
A 1 251 TYR 251 251 251 TYR TYR U . n 
A 1 252 GLU 252 252 252 GLU GLU U . n 
A 1 253 SER 253 253 253 SER SER U . n 
A 1 254 GLN 254 254 254 GLN GLN U . n 
A 1 255 GLY 255 255 255 GLY GLY U . n 
A 1 256 LEU 256 256 256 LEU LEU U . n 
A 1 257 TYR 257 257 257 TYR TYR U . n 
A 1 258 ARG 258 258 258 ARG ARG U . n 
A 1 259 PHE 259 259 259 PHE PHE U . n 
A 1 260 ALA 260 260 260 ALA ALA U . n 
A 1 261 ASN 261 261 261 ASN ASN U . n 
A 1 262 PHE 262 262 262 PHE PHE U . n 
A 1 263 VAL 263 263 263 VAL VAL U . n 
A 1 264 PHE 264 264 264 PHE PHE U . n 
A 1 265 ILE 265 265 265 ILE ILE U . n 
A 1 266 LEU 266 266 266 LEU LEU U . n 
A 1 267 MET 267 267 267 MET MET U . n 
A 1 268 GLY 268 268 268 GLY GLY U . n 
A 1 269 VAL 269 269 269 VAL VAL U . n 
A 1 270 CYS 270 270 270 CYS CYS U . n 
A 1 271 CYS 271 271 271 CYS CYS U . n 
A 1 272 ILE 272 272 272 ILE ILE U . n 
A 1 273 ALA 273 273 273 ALA ALA U . n 
A 1 274 SER 274 274 274 SER SER U . n 
A 1 275 LEU 275 275 275 LEU LEU U . n 
A 1 276 PHE 276 276 276 PHE PHE U . n 
A 1 277 ASN 277 277 277 ASN ASN U . n 
A 1 278 VAL 278 278 278 VAL VAL U . n 
A 1 279 ILE 279 279 279 ILE ILE U . n 
A 1 280 SER 280 280 280 SER SER U . n 
A 1 281 ILE 281 281 281 ILE ILE U . n 
A 1 282 LEU 282 282 282 LEU LEU U . n 
A 1 283 ILE 283 283 283 ILE ILE U . n 
A 1 284 LYS 284 284 284 LYS LYS U . n 
A 1 285 GLN 285 285 285 GLN GLN U . n 
A 1 286 SER 286 286 286 SER SER U . n 
A 1 287 LEU 287 287 287 LEU LEU U . n 
A 1 288 ASN 288 288 288 ASN ASN U . n 
A 1 289 TRP 289 289 289 TRP TRP U . n 
A 1 290 ILE 290 290 290 ILE ILE U . n 
A 1 291 LEU 291 291 291 LEU LEU U . n 
A 1 292 ARG 292 292 292 ARG ARG U . n 
A 1 293 LYS 293 293 293 LYS LYS U . n 
A 1 294 MET 294 294 294 MET MET U . n 
A 1 295 ASP 295 295 295 ASP ASP U . n 
A 1 296 SER 296 296 ?   ?   ?   U . n 
A 1 297 GLY 297 297 ?   ?   ?   U . n 
A 1 298 CYS 298 298 ?   ?   ?   U . n 
A 1 299 CYS 299 299 ?   ?   ?   U . n 
A 1 300 PRO 300 300 ?   ?   ?   U . n 
A 1 301 GLN 301 301 ?   ?   ?   U . n 
A 1 302 CYS 302 302 ?   ?   ?   U . n 
A 1 303 GLN 303 303 ?   ?   ?   U . n 
A 1 304 ARG 304 304 ?   ?   ?   U . n 
A 1 305 GLY 305 305 ?   ?   ?   U . n 
A 1 306 LEU 306 306 ?   ?   ?   U . n 
A 1 307 LEU 307 307 ?   ?   ?   U . n 
A 1 308 ARG 308 308 ?   ?   ?   U . n 
A 1 309 SER 309 309 ?   ?   ?   U . n 
A 1 310 ARG 310 310 ?   ?   ?   U . n 
A 1 311 ARG 311 311 ?   ?   ?   U . n 
A 1 312 ASN 312 312 ?   ?   ?   U . n 
A 1 313 VAL 313 313 ?   ?   ?   U . n 
A 1 314 VAL 314 314 ?   ?   ?   U . n 
A 1 315 MET 315 315 ?   ?   ?   U . n 
A 1 316 PRO 316 316 ?   ?   ?   U . n 
A 1 317 GLY 317 317 ?   ?   ?   U . n 
A 1 318 SER 318 318 ?   ?   ?   U . n 
A 1 319 VAL 319 319 ?   ?   ?   U . n 
A 1 320 ARG 320 320 ?   ?   ?   U . n 
A 1 321 ASN 321 321 ?   ?   ?   U . n 
A 1 322 ARG 322 322 ?   ?   ?   U . n 
A 1 323 CYS 323 323 ?   ?   ?   U . n 
A 1 324 ASN 324 324 ?   ?   ?   U . n 
A 1 325 ILE 325 325 ?   ?   ?   U . n 
A 1 326 SER 326 326 ?   ?   ?   U . n 
A 1 327 ILE 327 327 ?   ?   ?   U . n 
A 1 328 GLU 328 328 ?   ?   ?   U . n 
A 1 329 THR 329 329 ?   ?   ?   U . n 
A 1 330 ASP 330 330 ?   ?   ?   U . n 
A 1 331 GLY 331 331 ?   ?   ?   U . n 
A 1 332 VAL 332 332 ?   ?   ?   U . n 
A 1 333 ALA 333 333 ?   ?   ?   U . n 
A 1 334 GLU 334 334 ?   ?   ?   U . n 
A 1 335 SER 335 335 ?   ?   ?   U . n 
A 1 336 ASP 336 336 ?   ?   ?   U . n 
A 1 337 THR 337 337 ?   ?   ?   U . n 
A 1 338 ASP 338 338 ?   ?   ?   U . n 
A 1 339 GLY 339 339 ?   ?   ?   U . n 
A 1 340 ARG 340 340 ?   ?   ?   U . n 
A 1 341 ARG 341 341 ?   ?   ?   U . n 
A 1 342 LEU 342 342 ?   ?   ?   U . n 
A 1 343 SER 343 343 ?   ?   ?   U . n 
A 1 344 GLY 344 344 ?   ?   ?   U . n 
A 1 345 GLU 345 345 ?   ?   ?   U . n 
A 1 346 MET 346 346 ?   ?   ?   U . n 
A 1 347 ILE 347 347 ?   ?   ?   U . n 
A 1 348 SER 348 348 ?   ?   ?   U . n 
A 1 349 MET 349 349 ?   ?   ?   U . n 
A 1 350 LYS 350 350 ?   ?   ?   U . n 
B 1 1   MET 1   1   ?   ?   ?   A . n 
B 1 2   ALA 2   2   ?   ?   ?   A . n 
B 1 3   GLY 3   3   ?   ?   ?   A . n 
B 1 4   ARG 4   4   ?   ?   ?   A . n 
B 1 5   GLY 5   5   ?   ?   ?   A . n 
B 1 6   PHE 6   6   ?   ?   ?   A . n 
B 1 7   SER 7   7   ?   ?   ?   A . n 
B 1 8   TRP 8   8   ?   ?   ?   A . n 
B 1 9   GLY 9   9   ?   ?   ?   A . n 
B 1 10  PRO 10  10  ?   ?   ?   A . n 
B 1 11  GLY 11  11  ?   ?   ?   A . n 
B 1 12  HIS 12  12  ?   ?   ?   A . n 
B 1 13  LEU 13  13  ?   ?   ?   A . n 
B 1 14  ASN 14  14  14  ASN ASN A . n 
B 1 15  GLU 15  15  15  GLU GLU A . n 
B 1 16  ASP 16  16  16  ASP ASP A . n 
B 1 17  ASN 17  17  17  ASN ASN A . n 
B 1 18  ALA 18  18  18  ALA ALA A . n 
B 1 19  ARG 19  19  19  ARG ARG A . n 
B 1 20  PHE 20  20  20  PHE PHE A . n 
B 1 21  LEU 21  21  21  LEU LEU A . n 
B 1 22  LEU 22  22  22  LEU LEU A . n 
B 1 23  LEU 23  23  23  LEU LEU A . n 
B 1 24  ALA 24  24  24  ALA ALA A . n 
B 1 25  ALA 25  25  25  ALA ALA A . n 
B 1 26  LEU 26  26  26  LEU LEU A . n 
B 1 27  ILE 27  27  27  ILE ILE A . n 
B 1 28  VAL 28  28  28  VAL VAL A . n 
B 1 29  LEU 29  29  29  LEU LEU A . n 
B 1 30  TYR 30  30  30  TYR TYR A . n 
B 1 31  LEU 31  31  31  LEU LEU A . n 
B 1 32  LEU 32  32  32  LEU LEU A . n 
B 1 33  GLY 33  33  33  GLY GLY A . n 
B 1 34  GLY 34  34  34  GLY GLY A . n 
B 1 35  ALA 35  35  35  ALA ALA A . n 
B 1 36  ALA 36  36  36  ALA ALA A . n 
B 1 37  VAL 37  37  37  VAL VAL A . n 
B 1 38  PHE 38  38  38  PHE PHE A . n 
B 1 39  SER 39  39  39  SER SER A . n 
B 1 40  ALA 40  40  40  ALA ALA A . n 
B 1 41  LEU 41  41  41  LEU LEU A . n 
B 1 42  GLU 42  42  42  GLU GLU A . n 
B 1 43  LEU 43  43  43  LEU LEU A . n 
B 1 44  ALA 44  44  44  ALA ALA A . n 
B 1 45  HIS 45  45  45  HIS HIS A . n 
B 1 46  GLU 46  46  46  GLU GLU A . n 
B 1 47  ARG 47  47  47  ARG ARG A . n 
B 1 48  GLN 48  48  48  GLN GLN A . n 
B 1 49  ALA 49  49  49  ALA ALA A . n 
B 1 50  LYS 50  50  50  LYS LYS A . n 
B 1 51  GLN 51  51  51  GLN GLN A . n 
B 1 52  ARG 52  52  52  ARG ARG A . n 
B 1 53  TRP 53  53  53  TRP TRP A . n 
B 1 54  GLU 54  54  54  GLU GLU A . n 
B 1 55  GLU 55  55  55  GLU GLU A . n 
B 1 56  ARG 56  56  56  ARG ARG A . n 
B 1 57  LEU 57  57  57  LEU LEU A . n 
B 1 58  ALA 58  58  58  ALA ALA A . n 
B 1 59  GLN 59  59  59  GLN GLN A . n 
B 1 60  PHE 60  60  60  PHE PHE A . n 
B 1 61  SER 61  61  61  SER SER A . n 
B 1 62  ARG 62  62  62  ARG ARG A . n 
B 1 63  GLY 63  63  63  GLY GLY A . n 
B 1 64  HIS 64  64  64  HIS HIS A . n 
B 1 65  GLN 65  65  65  GLN GLN A . n 
B 1 66  LEU 66  66  66  LEU LEU A . n 
B 1 67  SER 67  67  67  SER SER A . n 
B 1 68  ARG 68  68  68  ARG ARG A . n 
B 1 69  ASP 69  69  69  ASP ASP A . n 
B 1 70  GLU 70  70  70  GLU GLU A . n 
B 1 71  LEU 71  71  71  LEU LEU A . n 
B 1 72  ARG 72  72  72  ARG ARG A . n 
B 1 73  GLY 73  73  73  GLY GLY A . n 
B 1 74  PHE 74  74  74  PHE PHE A . n 
B 1 75  LEU 75  75  75  LEU LEU A . n 
B 1 76  ARG 76  76  76  ARG ARG A . n 
B 1 77  HIS 77  77  77  HIS HIS A . n 
B 1 78  TYR 78  78  78  TYR TYR A . n 
B 1 79  GLU 79  79  79  GLU GLU A . n 
B 1 80  GLU 80  80  80  GLU GLU A . n 
B 1 81  ALA 81  81  81  ALA ALA A . n 
B 1 82  THR 82  82  82  THR THR A . n 
B 1 83  ARG 83  83  83  ARG ARG A . n 
B 1 84  ALA 84  84  84  ALA ALA A . n 
B 1 85  GLY 85  85  85  GLY GLY A . n 
B 1 86  ILE 86  86  86  ILE ILE A . n 
B 1 87  ARG 87  87  87  ARG ARG A . n 
B 1 88  VAL 88  88  88  VAL VAL A . n 
B 1 89  ASP 89  89  89  ASP ASP A . n 
B 1 90  ASN 90  90  90  ASN ASN A . n 
B 1 91  VAL 91  91  91  VAL VAL A . n 
B 1 92  ARG 92  92  92  ARG ARG A . n 
B 1 93  PRO 93  93  93  PRO PRO A . n 
B 1 94  ARG 94  94  94  ARG ARG A . n 
B 1 95  TRP 95  95  95  TRP TRP A . n 
B 1 96  ASP 96  96  96  ASP ASP A . n 
B 1 97  PHE 97  97  97  PHE PHE A . n 
B 1 98  THR 98  98  98  THR THR A . n 
B 1 99  GLY 99  99  99  GLY GLY A . n 
B 1 100 ALA 100 100 100 ALA ALA A . n 
B 1 101 PHE 101 101 101 PHE PHE A . n 
B 1 102 TYR 102 102 102 TYR TYR A . n 
B 1 103 PHE 103 103 103 PHE PHE A . n 
B 1 104 VAL 104 104 104 VAL VAL A . n 
B 1 105 GLY 105 105 105 GLY GLY A . n 
B 1 106 THR 106 106 106 THR THR A . n 
B 1 107 VAL 107 107 107 VAL VAL A . n 
B 1 108 VAL 108 108 108 VAL VAL A . n 
B 1 109 SER 109 109 109 SER SER A . n 
B 1 110 THR 110 110 110 THR THR A . n 
B 1 111 ILE 111 111 111 ILE ILE A . n 
B 1 112 GLY 112 112 112 GLY GLY A . n 
B 1 113 PHE 113 113 113 PHE PHE A . n 
B 1 114 GLY 114 114 114 GLY GLY A . n 
B 1 115 MET 115 115 115 MET MET A . n 
B 1 116 THR 116 116 116 THR THR A . n 
B 1 117 THR 117 117 117 THR THR A . n 
B 1 118 PRO 118 118 118 PRO PRO A . n 
B 1 119 ALA 119 119 119 ALA ALA A . n 
B 1 120 THR 120 120 120 THR THR A . n 
B 1 121 VAL 121 121 121 VAL VAL A . n 
B 1 122 GLY 122 122 122 GLY GLY A . n 
B 1 123 GLY 123 123 123 GLY GLY A . n 
B 1 124 LYS 124 124 124 LYS LYS A . n 
B 1 125 ILE 125 125 125 ILE ILE A . n 
B 1 126 PHE 126 126 126 PHE PHE A . n 
B 1 127 LEU 127 127 127 LEU LEU A . n 
B 1 128 ILE 128 128 128 ILE ILE A . n 
B 1 129 PHE 129 129 129 PHE PHE A . n 
B 1 130 TYR 130 130 130 TYR TYR A . n 
B 1 131 GLY 131 131 131 GLY GLY A . n 
B 1 132 LEU 132 132 132 LEU LEU A . n 
B 1 133 VAL 133 133 133 VAL VAL A . n 
B 1 134 GLY 134 134 134 GLY GLY A . n 
B 1 135 CYS 135 135 135 CYS CYS A . n 
B 1 136 PRO 136 136 136 PRO PRO A . n 
B 1 137 SER 137 137 137 SER SER A . n 
B 1 138 THR 138 138 138 THR THR A . n 
B 1 139 ILE 139 139 139 ILE ILE A . n 
B 1 140 LEU 140 140 140 LEU LEU A . n 
B 1 141 PHE 141 141 141 PHE PHE A . n 
B 1 142 PHE 142 142 142 PHE PHE A . n 
B 1 143 ASN 143 143 143 ASN ASN A . n 
B 1 144 LEU 144 144 144 LEU LEU A . n 
B 1 145 PHE 145 145 145 PHE PHE A . n 
B 1 146 LEU 146 146 146 LEU LEU A . n 
B 1 147 GLU 147 147 147 GLU GLU A . n 
B 1 148 ARG 148 148 148 ARG ARG A . n 
B 1 149 LEU 149 149 149 LEU LEU A . n 
B 1 150 ILE 150 150 150 ILE ILE A . n 
B 1 151 THR 151 151 151 THR THR A . n 
B 1 152 ILE 152 152 152 ILE ILE A . n 
B 1 153 ILE 153 153 153 ILE ILE A . n 
B 1 154 ALA 154 154 154 ALA ALA A . n 
B 1 155 TYR 155 155 155 TYR TYR A . n 
B 1 156 ILE 156 156 156 ILE ILE A . n 
B 1 157 MET 157 157 157 MET MET A . n 
B 1 158 LYS 158 158 158 LYS LYS A . n 
B 1 159 SER 159 159 159 SER SER A . n 
B 1 160 CYS 160 160 160 CYS CYS A . n 
B 1 161 HIS 161 161 161 HIS HIS A . n 
B 1 162 GLN 162 162 162 GLN GLN A . n 
B 1 163 ARG 163 163 ?   ?   ?   A . n 
B 1 164 GLN 164 164 ?   ?   ?   A . n 
B 1 165 LEU 165 165 ?   ?   ?   A . n 
B 1 166 ARG 166 166 ?   ?   ?   A . n 
B 1 167 ARG 167 167 ?   ?   ?   A . n 
B 1 168 ARG 168 168 ?   ?   ?   A . n 
B 1 169 GLY 169 169 ?   ?   ?   A . n 
B 1 170 ALA 170 170 ?   ?   ?   A . n 
B 1 171 LEU 171 171 ?   ?   ?   A . n 
B 1 172 PRO 172 172 ?   ?   ?   A . n 
B 1 173 GLN 173 173 ?   ?   ?   A . n 
B 1 174 GLU 174 174 ?   ?   ?   A . n 
B 1 175 SER 175 175 ?   ?   ?   A . n 
B 1 176 LEU 176 176 ?   ?   ?   A . n 
B 1 177 LYS 177 177 ?   ?   ?   A . n 
B 1 178 ASP 178 178 ?   ?   ?   A . n 
B 1 179 ALA 179 179 ?   ?   ?   A . n 
B 1 180 GLY 180 180 ?   ?   ?   A . n 
B 1 181 GLN 181 181 ?   ?   ?   A . n 
B 1 182 CYS 182 182 ?   ?   ?   A . n 
B 1 183 GLU 183 183 ?   ?   ?   A . n 
B 1 184 VAL 184 184 ?   ?   ?   A . n 
B 1 185 ASP 185 185 ?   ?   ?   A . n 
B 1 186 SER 186 186 ?   ?   ?   A . n 
B 1 187 LEU 187 187 ?   ?   ?   A . n 
B 1 188 ALA 188 188 188 ALA ALA A . n 
B 1 189 GLY 189 189 189 GLY GLY A . n 
B 1 190 TRP 190 190 190 TRP TRP A . n 
B 1 191 LYS 191 191 191 LYS LYS A . n 
B 1 192 PRO 192 192 192 PRO PRO A . n 
B 1 193 SER 193 193 193 SER SER A . n 
B 1 194 VAL 194 194 194 VAL VAL A . n 
B 1 195 TYR 195 195 195 TYR TYR A . n 
B 1 196 TYR 196 196 196 TYR TYR A . n 
B 1 197 VAL 197 197 197 VAL VAL A . n 
B 1 198 MET 198 198 198 MET MET A . n 
B 1 199 LEU 199 199 199 LEU LEU A . n 
B 1 200 ILE 200 200 200 ILE ILE A . n 
B 1 201 LEU 201 201 201 LEU LEU A . n 
B 1 202 CYS 202 202 202 CYS CYS A . n 
B 1 203 THR 203 203 203 THR THR A . n 
B 1 204 ALA 204 204 204 ALA ALA A . n 
B 1 205 SER 205 205 205 SER SER A . n 
B 1 206 ILE 206 206 206 ILE ILE A . n 
B 1 207 LEU 207 207 207 LEU LEU A . n 
B 1 208 ILE 208 208 208 ILE ILE A . n 
B 1 209 SER 209 209 209 SER SER A . n 
B 1 210 CYS 210 210 210 CYS CYS A . n 
B 1 211 CYS 211 211 211 CYS CYS A . n 
B 1 212 ALA 212 212 212 ALA ALA A . n 
B 1 213 SER 213 213 213 SER SER A . n 
B 1 214 ALA 214 214 214 ALA ALA A . n 
B 1 215 MET 215 215 215 MET MET A . n 
B 1 216 TYR 216 216 216 TYR TYR A . n 
B 1 217 THR 217 217 217 THR THR A . n 
B 1 218 PRO 218 218 218 PRO PRO A . n 
B 1 219 ILE 219 219 219 ILE ILE A . n 
B 1 220 GLU 220 220 220 GLU GLU A . n 
B 1 221 GLY 221 221 221 GLY GLY A . n 
B 1 222 TRP 222 222 222 TRP TRP A . n 
B 1 223 SER 223 223 223 SER SER A . n 
B 1 224 TYR 224 224 224 TYR TYR A . n 
B 1 225 PHE 225 225 225 PHE PHE A . n 
B 1 226 ASP 226 226 226 ASP ASP A . n 
B 1 227 SER 227 227 227 SER SER A . n 
B 1 228 LEU 228 228 228 LEU LEU A . n 
B 1 229 TYR 229 229 229 TYR TYR A . n 
B 1 230 PHE 230 230 230 PHE PHE A . n 
B 1 231 CYS 231 231 231 CYS CYS A . n 
B 1 232 PHE 232 232 232 PHE PHE A . n 
B 1 233 VAL 233 233 233 VAL VAL A . n 
B 1 234 ALA 234 234 234 ALA ALA A . n 
B 1 235 PHE 235 235 235 PHE PHE A . n 
B 1 236 SER 236 236 236 SER SER A . n 
B 1 237 THR 237 237 237 THR THR A . n 
B 1 238 ILE 238 238 238 ILE ILE A . n 
B 1 239 GLY 239 239 239 GLY GLY A . n 
B 1 240 PHE 240 240 240 PHE PHE A . n 
B 1 241 GLY 241 241 241 GLY GLY A . n 
B 1 242 ASP 242 242 242 ASP ASP A . n 
B 1 243 LEU 243 243 243 LEU LEU A . n 
B 1 244 VAL 244 244 244 VAL VAL A . n 
B 1 245 SER 245 245 245 SER SER A . n 
B 1 246 SER 246 246 246 SER SER A . n 
B 1 247 GLN 247 247 247 GLN GLN A . n 
B 1 248 ASN 248 248 248 ASN ASN A . n 
B 1 249 ALA 249 249 249 ALA ALA A . n 
B 1 250 HIS 250 250 250 HIS HIS A . n 
B 1 251 TYR 251 251 251 TYR TYR A . n 
B 1 252 GLU 252 252 252 GLU GLU A . n 
B 1 253 SER 253 253 253 SER SER A . n 
B 1 254 GLN 254 254 254 GLN GLN A . n 
B 1 255 GLY 255 255 255 GLY GLY A . n 
B 1 256 LEU 256 256 256 LEU LEU A . n 
B 1 257 TYR 257 257 257 TYR TYR A . n 
B 1 258 ARG 258 258 258 ARG ARG A . n 
B 1 259 PHE 259 259 259 PHE PHE A . n 
B 1 260 ALA 260 260 260 ALA ALA A . n 
B 1 261 ASN 261 261 261 ASN ASN A . n 
B 1 262 PHE 262 262 262 PHE PHE A . n 
B 1 263 VAL 263 263 263 VAL VAL A . n 
B 1 264 PHE 264 264 264 PHE PHE A . n 
B 1 265 ILE 265 265 265 ILE ILE A . n 
B 1 266 LEU 266 266 266 LEU LEU A . n 
B 1 267 MET 267 267 267 MET MET A . n 
B 1 268 GLY 268 268 268 GLY GLY A . n 
B 1 269 VAL 269 269 269 VAL VAL A . n 
B 1 270 CYS 270 270 270 CYS CYS A . n 
B 1 271 CYS 271 271 271 CYS CYS A . n 
B 1 272 ILE 272 272 272 ILE ILE A . n 
B 1 273 ALA 273 273 273 ALA ALA A . n 
B 1 274 SER 274 274 274 SER SER A . n 
B 1 275 LEU 275 275 275 LEU LEU A . n 
B 1 276 PHE 276 276 276 PHE PHE A . n 
B 1 277 ASN 277 277 277 ASN ASN A . n 
B 1 278 VAL 278 278 278 VAL VAL A . n 
B 1 279 ILE 279 279 279 ILE ILE A . n 
B 1 280 SER 280 280 280 SER SER A . n 
B 1 281 ILE 281 281 281 ILE ILE A . n 
B 1 282 LEU 282 282 282 LEU LEU A . n 
B 1 283 ILE 283 283 283 ILE ILE A . n 
B 1 284 LYS 284 284 284 LYS LYS A . n 
B 1 285 GLN 285 285 285 GLN GLN A . n 
B 1 286 SER 286 286 286 SER SER A . n 
B 1 287 LEU 287 287 287 LEU LEU A . n 
B 1 288 ASN 288 288 288 ASN ASN A . n 
B 1 289 TRP 289 289 289 TRP TRP A . n 
B 1 290 ILE 290 290 290 ILE ILE A . n 
B 1 291 LEU 291 291 291 LEU LEU A . n 
B 1 292 ARG 292 292 292 ARG ARG A . n 
B 1 293 LYS 293 293 293 LYS LYS A . n 
B 1 294 MET 294 294 294 MET MET A . n 
B 1 295 ASP 295 295 295 ASP ASP A . n 
B 1 296 SER 296 296 ?   ?   ?   A . n 
B 1 297 GLY 297 297 ?   ?   ?   A . n 
B 1 298 CYS 298 298 ?   ?   ?   A . n 
B 1 299 CYS 299 299 ?   ?   ?   A . n 
B 1 300 PRO 300 300 ?   ?   ?   A . n 
B 1 301 GLN 301 301 ?   ?   ?   A . n 
B 1 302 CYS 302 302 ?   ?   ?   A . n 
B 1 303 GLN 303 303 ?   ?   ?   A . n 
B 1 304 ARG 304 304 ?   ?   ?   A . n 
B 1 305 GLY 305 305 ?   ?   ?   A . n 
B 1 306 LEU 306 306 ?   ?   ?   A . n 
B 1 307 LEU 307 307 ?   ?   ?   A . n 
B 1 308 ARG 308 308 ?   ?   ?   A . n 
B 1 309 SER 309 309 ?   ?   ?   A . n 
B 1 310 ARG 310 310 ?   ?   ?   A . n 
B 1 311 ARG 311 311 ?   ?   ?   A . n 
B 1 312 ASN 312 312 ?   ?   ?   A . n 
B 1 313 VAL 313 313 ?   ?   ?   A . n 
B 1 314 VAL 314 314 ?   ?   ?   A . n 
B 1 315 MET 315 315 ?   ?   ?   A . n 
B 1 316 PRO 316 316 ?   ?   ?   A . n 
B 1 317 GLY 317 317 ?   ?   ?   A . n 
B 1 318 SER 318 318 ?   ?   ?   A . n 
B 1 319 VAL 319 319 ?   ?   ?   A . n 
B 1 320 ARG 320 320 ?   ?   ?   A . n 
B 1 321 ASN 321 321 ?   ?   ?   A . n 
B 1 322 ARG 322 322 ?   ?   ?   A . n 
B 1 323 CYS 323 323 ?   ?   ?   A . n 
B 1 324 ASN 324 324 ?   ?   ?   A . n 
B 1 325 ILE 325 325 ?   ?   ?   A . n 
B 1 326 SER 326 326 ?   ?   ?   A . n 
B 1 327 ILE 327 327 ?   ?   ?   A . n 
B 1 328 GLU 328 328 ?   ?   ?   A . n 
B 1 329 THR 329 329 ?   ?   ?   A . n 
B 1 330 ASP 330 330 ?   ?   ?   A . n 
B 1 331 GLY 331 331 ?   ?   ?   A . n 
B 1 332 VAL 332 332 ?   ?   ?   A . n 
B 1 333 ALA 333 333 ?   ?   ?   A . n 
B 1 334 GLU 334 334 ?   ?   ?   A . n 
B 1 335 SER 335 335 ?   ?   ?   A . n 
B 1 336 ASP 336 336 ?   ?   ?   A . n 
B 1 337 THR 337 337 ?   ?   ?   A . n 
B 1 338 ASP 338 338 ?   ?   ?   A . n 
B 1 339 GLY 339 339 ?   ?   ?   A . n 
B 1 340 ARG 340 340 ?   ?   ?   A . n 
B 1 341 ARG 341 341 ?   ?   ?   A . n 
B 1 342 LEU 342 342 ?   ?   ?   A . n 
B 1 343 SER 343 343 ?   ?   ?   A . n 
B 1 344 GLY 344 344 ?   ?   ?   A . n 
B 1 345 GLU 345 345 ?   ?   ?   A . n 
B 1 346 MET 346 346 ?   ?   ?   A . n 
B 1 347 ILE 347 347 ?   ?   ?   A . n 
B 1 348 SER 348 348 ?   ?   ?   A . n 
B 1 349 MET 349 349 ?   ?   ?   A . n 
B 1 350 LYS 350 350 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        EIC 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   EIC 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 D12 1 401 302 D12 D12 U . 
D 3 D10 1 402 303 D10 D10 U . 
E 4 OCT 1 403 304 OCT D08 U . 
F 4 OCT 1 404 306 OCT D08 U . 
G 3 D10 1 405 307 D10 D10 U . 
H 5 HEX 1 406 308 HEX D06 U . 
I 6 EIC 1 407 309 EIC EIC U . 
J 4 OCT 1 408 304 OCT D08 U . 
K 4 OCT 1 409 308 OCT D08 U . 
L 7 K   1 410 3   K   K   U . 
M 4 OCT 1 401 305 OCT D08 A . 
N 2 D12 1 402 302 D12 D12 A . 
O 3 D10 1 403 303 D10 D10 A . 
P 4 OCT 1 404 305 OCT D08 A . 
Q 4 OCT 1 405 306 OCT D08 A . 
R 3 D10 1 406 307 D10 D10 A . 
S 4 OCT 1 407 309 OCT D08 A . 
T 5 HEX 1 408 310 HEX D06 A . 
U 6 EIC 1 409 311 EIC EIC A . 
V 7 K   1 410 1   K   K   A . 
W 7 K   1 411 2   K   K   A . 
X 7 K   1 412 4   K   K   A . 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BWS 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BWS 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BWS 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     9BWS 
_struct.title                        'Structure of human k2P13.1 (THIK-1) S136P Y273A in lipid nanodisc' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BWS 
_struct_keywords.text            'ion channel, k2p channel, membrane protein, TRANSPORT PROTEIN' 
_struct_keywords.pdbx_keywords   'TRANSPORT PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
G N N 3 ? 
H N N 5 ? 
I N N 6 ? 
J N N 4 ? 
K N N 4 ? 
L N N 7 ? 
M N N 4 ? 
N N N 2 ? 
O N N 3 ? 
P N N 4 ? 
Q N N 4 ? 
R N N 3 ? 
S N N 4 ? 
T N N 5 ? 
U N N 6 ? 
V N N 7 ? 
W N N 7 ? 
X N N 7 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    KCNKD_HUMAN 
_struct_ref.pdbx_db_accession          Q9HB14 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MAGRGFSWGPGHLNEDNARFLLLAALIVLYLLGGAAVFSALELAHERQAKQRWEERLANFSRGHNLSRDELRGFLRHYEE
ATRAGIRVDNVRPRWDFTGAFYFVGTVVSTIGFGMTTPATVGGKIFLIFYGLVGCSSTILFFNLFLERLITIIAYIMKSC
HQRQLRRRGALPQESLKDAGQCEVDSLAGWKPSVYYVMLILCTASILISCCASAMYTPIEGWSYFDSLYFCFVAFSTIGF
GDLVSSQNAHYESQGLYRFANFVFILMGVCCIYSLFNVISILIKQSLNWILRKMDSGCCPQCQRGLLRSRRNVVMPGSVR
NRCNISIETDGVAESDTDGRRLSGEMISMK
;
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9BWS U 1 ? 350 ? Q9HB14 1 ? 350 ? 1 350 
2 1 9BWS A 1 ? 350 ? Q9HB14 1 ? 350 ? 1 350 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9BWS GLN U 59  ? UNP Q9HB14 ASN 59  'engineered mutation' 59  1 
1 9BWS GLN U 65  ? UNP Q9HB14 ASN 65  'engineered mutation' 65  2 
1 9BWS PRO U 136 ? UNP Q9HB14 SER 136 'engineered mutation' 136 3 
1 9BWS ALA U 273 ? UNP Q9HB14 TYR 273 'engineered mutation' 273 4 
2 9BWS GLN A 59  ? UNP Q9HB14 ASN 59  'engineered mutation' 59  5 
2 9BWS GLN A 65  ? UNP Q9HB14 ASN 65  'engineered mutation' 65  6 
2 9BWS PRO A 136 ? UNP Q9HB14 SER 136 'engineered mutation' 136 7 
2 9BWS ALA A 273 ? UNP Q9HB14 TYR 273 'engineered mutation' 273 8 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V,W,X 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 14  ? GLN A 65  ? ASN U 14  GLN U 65  1 ? 52 
HELX_P HELX_P2  AA2 SER A 67  ? ARG A 83  ? SER U 67  ARG U 83  1 ? 17 
HELX_P HELX_P3  AA3 PHE A 97  ? SER A 109 ? PHE U 97  SER U 109 1 ? 13 
HELX_P HELX_P4  AA4 LYS A 124 ? GLN A 162 ? LYS U 124 GLN U 162 1 ? 39 
HELX_P HELX_P5  AA5 SER A 193 ? MET A 215 ? SER U 193 MET U 215 1 ? 23 
HELX_P HELX_P6  AA6 SER A 223 ? SER A 236 ? SER U 223 SER U 236 1 ? 14 
HELX_P HELX_P7  AA7 GLY A 255 ? MET A 294 ? GLY U 255 MET U 294 1 ? 40 
HELX_P HELX_P8  AA8 GLU B 15  ? HIS B 64  ? GLU A 15  HIS A 64  1 ? 50 
HELX_P HELX_P9  AA9 SER B 67  ? GLY B 85  ? SER A 67  GLY A 85  1 ? 19 
HELX_P HELX_P10 AB1 ASP B 96  ? SER B 109 ? ASP A 96  SER A 109 1 ? 14 
HELX_P HELX_P11 AB2 GLY B 122 ? GLN B 162 ? GLY A 122 GLN A 162 1 ? 41 
HELX_P HELX_P12 AB3 SER B 193 ? GLU B 220 ? SER A 193 GLU A 220 1 ? 28 
HELX_P HELX_P13 AB4 SER B 223 ? SER B 236 ? SER A 223 SER A 236 1 ? 14 
HELX_P HELX_P14 AB5 GLY B 255 ? MET B 294 ? GLY A 255 MET A 294 1 ? 40 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A THR 110 O   ? ? ? 1_555 L K   .   K ? ? U THR 110 U K   410 1_555 ? ? ? ? ? ? ? 2.802 ? ? 
metalc2  metalc ? ? A THR 110 O   ? ? ? 1_555 W K   .   K ? ? U THR 110 A K   411 1_555 ? ? ? ? ? ? ? 3.406 ? ? 
metalc3  metalc ? ? A ILE 111 O   ? ? ? 1_555 W K   .   K ? ? U ILE 111 A K   411 1_555 ? ? ? ? ? ? ? 2.637 ? ? 
metalc4  metalc ? ? A ILE 111 O   ? ? ? 1_555 X K   .   K ? ? U ILE 111 A K   412 1_555 ? ? ? ? ? ? ? 2.928 ? ? 
metalc5  metalc ? ? A GLY 112 O   ? ? ? 1_555 V K   .   K ? ? U GLY 112 A K   410 1_555 ? ? ? ? ? ? ? 2.948 ? ? 
metalc6  metalc ? ? A GLY 112 O   ? ? ? 1_555 X K   .   K ? ? U GLY 112 A K   412 1_555 ? ? ? ? ? ? ? 2.894 ? ? 
metalc7  metalc ? ? A PHE 113 O   ? ? ? 1_555 V K   .   K ? ? U PHE 113 A K   410 1_555 ? ? ? ? ? ? ? 3.098 ? ? 
metalc8  metalc ? ? A THR 237 O   ? ? ? 1_555 L K   .   K ? ? U THR 237 U K   410 1_555 ? ? ? ? ? ? ? 2.819 ? ? 
metalc9  metalc ? ? A THR 237 OG1 ? ? ? 1_555 L K   .   K ? ? U THR 237 U K   410 1_555 ? ? ? ? ? ? ? 3.405 ? ? 
metalc10 metalc ? ? A THR 237 O   ? ? ? 1_555 W K   .   K ? ? U THR 237 A K   411 1_555 ? ? ? ? ? ? ? 3.157 ? ? 
metalc11 metalc ? ? A ILE 238 O   ? ? ? 1_555 W K   .   K ? ? U ILE 238 A K   411 1_555 ? ? ? ? ? ? ? 2.760 ? ? 
metalc12 metalc ? ? A ILE 238 O   ? ? ? 1_555 X K   .   K ? ? U ILE 238 A K   412 1_555 ? ? ? ? ? ? ? 2.928 ? ? 
metalc13 metalc ? ? A GLY 239 O   ? ? ? 1_555 V K   .   K ? ? U GLY 239 A K   410 1_555 ? ? ? ? ? ? ? 2.800 ? ? 
metalc14 metalc ? ? A GLY 239 O   ? ? ? 1_555 X K   .   K ? ? U GLY 239 A K   412 1_555 ? ? ? ? ? ? ? 2.876 ? ? 
metalc15 metalc ? ? A PHE 240 O   ? ? ? 1_555 V K   .   K ? ? U PHE 240 A K   410 1_555 ? ? ? ? ? ? ? 3.168 ? ? 
metalc16 metalc ? ? L K   .   K   ? ? ? 1_555 B THR 110 O ? ? U K   410 A THR 110 1_555 ? ? ? ? ? ? ? 2.872 ? ? 
metalc17 metalc ? ? L K   .   K   ? ? ? 1_555 B THR 237 O ? ? U K   410 A THR 237 1_555 ? ? ? ? ? ? ? 2.850 ? ? 
metalc18 metalc ? ? B THR 110 O   ? ? ? 1_555 W K   .   K ? ? A THR 110 A K   411 1_555 ? ? ? ? ? ? ? 3.457 ? ? 
metalc19 metalc ? ? B ILE 111 O   ? ? ? 1_555 W K   .   K ? ? A ILE 111 A K   411 1_555 ? ? ? ? ? ? ? 2.714 ? ? 
metalc20 metalc ? ? B ILE 111 O   ? ? ? 1_555 X K   .   K ? ? A ILE 111 A K   412 1_555 ? ? ? ? ? ? ? 2.979 ? ? 
metalc21 metalc ? ? B GLY 112 O   ? ? ? 1_555 V K   .   K ? ? A GLY 112 A K   410 1_555 ? ? ? ? ? ? ? 3.009 ? ? 
metalc22 metalc ? ? B GLY 112 O   ? ? ? 1_555 X K   .   K ? ? A GLY 112 A K   412 1_555 ? ? ? ? ? ? ? 3.046 ? ? 
metalc23 metalc ? ? B PHE 113 O   ? ? ? 1_555 V K   .   K ? ? A PHE 113 A K   410 1_555 ? ? ? ? ? ? ? 3.146 ? ? 
metalc24 metalc ? ? B THR 237 O   ? ? ? 1_555 W K   .   K ? ? A THR 237 A K   411 1_555 ? ? ? ? ? ? ? 3.192 ? ? 
metalc25 metalc ? ? B ILE 238 O   ? ? ? 1_555 W K   .   K ? ? A ILE 238 A K   411 1_555 ? ? ? ? ? ? ? 2.775 ? ? 
metalc26 metalc ? ? B ILE 238 O   ? ? ? 1_555 X K   .   K ? ? A ILE 238 A K   412 1_555 ? ? ? ? ? ? ? 2.965 ? ? 
metalc27 metalc ? ? B GLY 239 O   ? ? ? 1_555 V K   .   K ? ? A GLY 239 A K   410 1_555 ? ? ? ? ? ? ? 2.837 ? ? 
metalc28 metalc ? ? B GLY 239 O   ? ? ? 1_555 X K   .   K ? ? A GLY 239 A K   412 1_555 ? ? ? ? ? ? ? 2.832 ? ? 
metalc29 metalc ? ? B PHE 240 O   ? ? ? 1_555 V K   .   K ? ? A PHE 240 A K   410 1_555 ? ? ? ? ? ? ? 3.243 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  O   ? A THR 110 ? U THR 110 ? 1_555 K ? L K . ? U K 410 ? 1_555 O   ? A THR 237 ? U THR 237 ? 1_555 75.6  ? 
2  O   ? A THR 110 ? U THR 110 ? 1_555 K ? L K . ? U K 410 ? 1_555 OG1 ? A THR 237 ? U THR 237 ? 1_555 92.7  ? 
3  O   ? A THR 237 ? U THR 237 ? 1_555 K ? L K . ? U K 410 ? 1_555 OG1 ? A THR 237 ? U THR 237 ? 1_555 56.2  ? 
4  O   ? A THR 110 ? U THR 110 ? 1_555 K ? L K . ? U K 410 ? 1_555 O   ? B THR 110 ? A THR 110 ? 1_555 121.5 ? 
5  O   ? A THR 237 ? U THR 237 ? 1_555 K ? L K . ? U K 410 ? 1_555 O   ? B THR 110 ? A THR 110 ? 1_555 73.4  ? 
6  OG1 ? A THR 237 ? U THR 237 ? 1_555 K ? L K . ? U K 410 ? 1_555 O   ? B THR 110 ? A THR 110 ? 1_555 108.5 ? 
7  O   ? A THR 110 ? U THR 110 ? 1_555 K ? L K . ? U K 410 ? 1_555 O   ? B THR 237 ? A THR 237 ? 1_555 73.3  ? 
8  O   ? A THR 237 ? U THR 237 ? 1_555 K ? L K . ? U K 410 ? 1_555 O   ? B THR 237 ? A THR 237 ? 1_555 110.8 ? 
9  OG1 ? A THR 237 ? U THR 237 ? 1_555 K ? L K . ? U K 410 ? 1_555 O   ? B THR 237 ? A THR 237 ? 1_555 163.7 ? 
10 O   ? B THR 110 ? A THR 110 ? 1_555 K ? L K . ? U K 410 ? 1_555 O   ? B THR 237 ? A THR 237 ? 1_555 73.3  ? 
11 O   ? A THR 110 ? U THR 110 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? A ILE 111 ? U ILE 111 ? 1_555 72.3  ? 
12 O   ? A THR 110 ? U THR 110 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? A THR 237 ? U THR 237 ? 1_555 63.2  ? 
13 O   ? A ILE 111 ? U ILE 111 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? A THR 237 ? U THR 237 ? 1_555 94.3  ? 
14 O   ? A THR 110 ? U THR 110 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? A ILE 238 ? U ILE 238 ? 1_555 128.6 ? 
15 O   ? A ILE 111 ? U ILE 111 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? A ILE 238 ? U ILE 238 ? 1_555 85.2  ? 
16 O   ? A THR 237 ? U THR 237 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? A ILE 238 ? U ILE 238 ? 1_555 73.7  ? 
17 O   ? A THR 110 ? U THR 110 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? B THR 110 ? A THR 110 ? 1_555 92.3  ? 
18 O   ? A ILE 111 ? U ILE 111 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? B THR 110 ? A THR 110 ? 1_555 155.8 ? 
19 O   ? A THR 237 ? U THR 237 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? B THR 110 ? A THR 110 ? 1_555 61.7  ? 
20 O   ? A ILE 238 ? U ILE 238 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? B THR 110 ? A THR 110 ? 1_555 90.5  ? 
21 O   ? A THR 110 ? U THR 110 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? B ILE 111 ? A ILE 111 ? 1_555 153.5 ? 
22 O   ? A ILE 111 ? U ILE 111 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? B ILE 111 ? A ILE 111 ? 1_555 130.0 ? 
23 O   ? A THR 237 ? U THR 237 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? B ILE 111 ? A ILE 111 ? 1_555 120.5 ? 
24 O   ? A ILE 238 ? U ILE 238 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? B ILE 111 ? A ILE 111 ? 1_555 73.3  ? 
25 O   ? B THR 110 ? A THR 110 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? B ILE 111 ? A ILE 111 ? 1_555 70.6  ? 
26 O   ? A THR 110 ? U THR 110 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? B THR 237 ? A THR 237 ? 1_555 61.4  ? 
27 O   ? A ILE 111 ? U ILE 111 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? B THR 237 ? A THR 237 ? 1_555 121.6 ? 
28 O   ? A THR 237 ? U THR 237 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? B THR 237 ? A THR 237 ? 1_555 94.6  ? 
29 O   ? A ILE 238 ? U ILE 238 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? B THR 237 ? A THR 237 ? 1_555 151.9 ? 
30 O   ? B THR 110 ? A THR 110 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? B THR 237 ? A THR 237 ? 1_555 61.7  ? 
31 O   ? B ILE 111 ? A ILE 111 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? B THR 237 ? A THR 237 ? 1_555 92.2  ? 
32 O   ? A THR 110 ? U THR 110 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? B ILE 238 ? A ILE 238 ? 1_555 90.6  ? 
33 O   ? A ILE 111 ? U ILE 111 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? B ILE 238 ? A ILE 238 ? 1_555 74.3  ? 
34 O   ? A THR 237 ? U THR 237 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? B ILE 238 ? A ILE 238 ? 1_555 153.7 ? 
35 O   ? A ILE 238 ? U ILE 238 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? B ILE 238 ? A ILE 238 ? 1_555 127.3 ? 
36 O   ? B THR 110 ? A THR 110 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? B ILE 238 ? A ILE 238 ? 1_555 125.7 ? 
37 O   ? B ILE 111 ? A ILE 111 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? B ILE 238 ? A ILE 238 ? 1_555 83.7  ? 
38 O   ? B THR 237 ? A THR 237 ? 1_555 K ? W K . ? A K 411 ? 1_555 O   ? B ILE 238 ? A ILE 238 ? 1_555 72.8  ? 
39 O   ? A ILE 111 ? U ILE 111 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? A GLY 112 ? U GLY 112 ? 1_555 72.4  ? 
40 O   ? A ILE 111 ? U ILE 111 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? A ILE 238 ? U ILE 238 ? 1_555 77.2  ? 
41 O   ? A GLY 112 ? U GLY 112 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? A ILE 238 ? U ILE 238 ? 1_555 137.7 ? 
42 O   ? A ILE 111 ? U ILE 111 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? A GLY 239 ? U GLY 239 ? 1_555 91.3  ? 
43 O   ? A GLY 112 ? U GLY 112 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? A GLY 239 ? U GLY 239 ? 1_555 78.7  ? 
44 O   ? A ILE 238 ? U ILE 238 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? A GLY 239 ? U GLY 239 ? 1_555 73.2  ? 
45 O   ? A ILE 111 ? U ILE 111 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? B ILE 111 ? A ILE 111 ? 1_555 110.4 ? 
46 O   ? A GLY 112 ? U GLY 112 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? B ILE 111 ? A ILE 111 ? 1_555 151.9 ? 
47 O   ? A ILE 238 ? U ILE 238 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? B ILE 111 ? A ILE 111 ? 1_555 67.2  ? 
48 O   ? A GLY 239 ? U GLY 239 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? B ILE 111 ? A ILE 111 ? 1_555 128.2 ? 
49 O   ? A ILE 111 ? U ILE 111 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? B GLY 112 ? A GLY 112 ? 1_555 152.6 ? 
50 O   ? A GLY 112 ? U GLY 112 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? B GLY 112 ? A GLY 112 ? 1_555 119.1 ? 
51 O   ? A ILE 238 ? U ILE 238 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? B GLY 112 ? A GLY 112 ? 1_555 79.0  ? 
52 O   ? A GLY 239 ? U GLY 239 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? B GLY 112 ? A GLY 112 ? 1_555 68.8  ? 
53 O   ? B ILE 111 ? A ILE 111 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? B GLY 112 ? A GLY 112 ? 1_555 71.9  ? 
54 O   ? A ILE 111 ? U ILE 111 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? B ILE 238 ? A ILE 238 ? 1_555 67.4  ? 
55 O   ? A GLY 112 ? U GLY 112 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? B ILE 238 ? A ILE 238 ? 1_555 79.7  ? 
56 O   ? A ILE 238 ? U ILE 238 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? B ILE 238 ? A ILE 238 ? 1_555 114.6 ? 
57 O   ? A GLY 239 ? U GLY 239 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? B ILE 238 ? A ILE 238 ? 1_555 153.5 ? 
58 O   ? B ILE 111 ? A ILE 111 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? B ILE 238 ? A ILE 238 ? 1_555 76.1  ? 
59 O   ? B GLY 112 ? A GLY 112 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? B ILE 238 ? A ILE 238 ? 1_555 136.3 ? 
60 O   ? A ILE 111 ? U ILE 111 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? B GLY 239 ? A GLY 239 ? 1_555 125.8 ? 
61 O   ? A GLY 112 ? U GLY 112 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? B GLY 239 ? A GLY 239 ? 1_555 67.7  ? 
62 O   ? A ILE 238 ? U ILE 238 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? B GLY 239 ? A GLY 239 ? 1_555 153.7 ? 
63 O   ? A GLY 239 ? U GLY 239 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? B GLY 239 ? A GLY 239 ? 1_555 114.4 ? 
64 O   ? B ILE 111 ? A ILE 111 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? B GLY 239 ? A GLY 239 ? 1_555 90.6  ? 
65 O   ? B GLY 112 ? A GLY 112 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? B GLY 239 ? A GLY 239 ? 1_555 80.8  ? 
66 O   ? B ILE 238 ? A ILE 238 ? 1_555 K ? X K . ? A K 412 ? 1_555 O   ? B GLY 239 ? A GLY 239 ? 1_555 70.6  ? 
67 O   ? A GLY 112 ? U GLY 112 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? A PHE 113 ? U PHE 113 ? 1_555 67.2  ? 
68 O   ? A GLY 112 ? U GLY 112 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? A GLY 239 ? U GLY 239 ? 1_555 79.0  ? 
69 O   ? A PHE 113 ? U PHE 113 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? A GLY 239 ? U GLY 239 ? 1_555 85.0  ? 
70 O   ? A GLY 112 ? U GLY 112 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? A PHE 240 ? U PHE 240 ? 1_555 132.7 ? 
71 O   ? A PHE 113 ? U PHE 113 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? A PHE 240 ? U PHE 240 ? 1_555 78.6  ? 
72 O   ? A GLY 239 ? U GLY 239 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? A PHE 240 ? U PHE 240 ? 1_555 65.9  ? 
73 O   ? A GLY 112 ? U GLY 112 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? B GLY 112 ? A GLY 112 ? 1_555 118.6 ? 
74 O   ? A PHE 113 ? U PHE 113 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? B GLY 112 ? A GLY 112 ? 1_555 151.9 ? 
75 O   ? A GLY 239 ? U GLY 239 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? B GLY 112 ? A GLY 112 ? 1_555 70.3  ? 
76 O   ? A PHE 240 ? U PHE 240 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? B GLY 112 ? A GLY 112 ? 1_555 79.1  ? 
77 O   ? A GLY 112 ? U GLY 112 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? B PHE 113 ? A PHE 113 ? 1_555 150.3 ? 
78 O   ? A PHE 113 ? U PHE 113 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? B PHE 113 ? A PHE 113 ? 1_555 124.6 ? 
79 O   ? A GLY 239 ? U GLY 239 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? B PHE 113 ? A PHE 113 ? 1_555 126.0 ? 
80 O   ? A PHE 240 ? U PHE 240 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? B PHE 113 ? A PHE 113 ? 1_555 76.5  ? 
81 O   ? B GLY 112 ? A GLY 112 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? B PHE 113 ? A PHE 113 ? 1_555 65.5  ? 
82 O   ? A GLY 112 ? U GLY 112 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? B GLY 239 ? A GLY 239 ? 1_555 66.9  ? 
83 O   ? A PHE 113 ? U PHE 113 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? B GLY 239 ? A GLY 239 ? 1_555 123.1 ? 
84 O   ? A GLY 239 ? U GLY 239 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? B GLY 239 ? A GLY 239 ? 1_555 116.7 ? 
85 O   ? A PHE 240 ? U PHE 240 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? B GLY 239 ? A GLY 239 ? 1_555 157.8 ? 
86 O   ? B GLY 112 ? A GLY 112 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? B GLY 239 ? A GLY 239 ? 1_555 81.3  ? 
87 O   ? B PHE 113 ? A PHE 113 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? B GLY 239 ? A GLY 239 ? 1_555 85.9  ? 
88 O   ? A GLY 112 ? U GLY 112 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? B PHE 240 ? A PHE 240 ? 1_555 81.4  ? 
89 O   ? A PHE 113 ? U PHE 113 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? B PHE 240 ? A PHE 240 ? 1_555 76.0  ? 
90 O   ? A GLY 239 ? U GLY 239 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? B PHE 240 ? A PHE 240 ? 1_555 156.8 ? 
91 O   ? A PHE 240 ? U PHE 240 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? B PHE 240 ? A PHE 240 ? 1_555 121.6 ? 
92 O   ? B GLY 112 ? A GLY 112 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? B PHE 240 ? A PHE 240 ? 1_555 131.0 ? 
93 O   ? B PHE 113 ? A PHE 113 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? B PHE 240 ? A PHE 240 ? 1_555 76.5  ? 
94 O   ? B GLY 239 ? A GLY 239 ? 1_555 K ? V K . ? A K 410 ? 1_555 O   ? B PHE 240 ? A PHE 240 ? 1_555 65.6  ? 
# 
_pdbx_entry_details.entry_id                   9BWS 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 GLN U 65  ? ? 55.80   18.56   
2  1 ASP U 96  ? ? -82.69  -74.27  
3  1 PHE U 97  ? ? -144.19 -26.01  
4  1 TYR U 216 ? ? 76.37   -24.99  
5  1 ASN U 248 ? ? -143.26 31.09   
6  1 ALA U 249 ? ? 58.54   -114.40 
7  1 GLU U 252 ? ? 51.73   -115.04 
8  1 GLN U 254 ? ? 68.62   -6.65   
9  1 TRP A 95  ? ? 54.08   16.40   
10 1 ALA A 249 ? ? 57.01   -117.87 
11 1 GLU A 252 ? ? 45.84   -123.75 
12 1 GLN A 254 ? ? 68.84   -5.69   
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9BWS 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9BWS 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  2.39 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               493313 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.8 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Human K2P13.1 with S136P and Y273A muatations in lipid nanodisc' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        9BWS 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           'FEI TITAN KRIOS AUTOGRID HOLDER' 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    COPPER 
_em_sample_support.grid_mesh_size   300 
_em_sample_support.grid_type        'Quantifoil R1.2/1.3' 
_em_sample_support.details          ? 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_vitrification.entry_id              9BWS 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              100 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   277.15 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9BWS 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
_em_single_particle_entity.entry_id              9BWS 
_em_single_particle_entity.id                    1 
_em_single_particle_entity.image_processing_id   1 
_em_single_particle_entity.point_symmetry        C2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 U MET 1   ? A MET 1   
2   1 Y 1 U ALA 2   ? A ALA 2   
3   1 Y 1 U GLY 3   ? A GLY 3   
4   1 Y 1 U ARG 4   ? A ARG 4   
5   1 Y 1 U GLY 5   ? A GLY 5   
6   1 Y 1 U PHE 6   ? A PHE 6   
7   1 Y 1 U SER 7   ? A SER 7   
8   1 Y 1 U TRP 8   ? A TRP 8   
9   1 Y 1 U GLY 9   ? A GLY 9   
10  1 Y 1 U PRO 10  ? A PRO 10  
11  1 Y 1 U GLY 11  ? A GLY 11  
12  1 Y 1 U HIS 12  ? A HIS 12  
13  1 Y 1 U LEU 13  ? A LEU 13  
14  1 Y 1 U ARG 163 ? A ARG 163 
15  1 Y 1 U GLN 164 ? A GLN 164 
16  1 Y 1 U LEU 165 ? A LEU 165 
17  1 Y 1 U ARG 166 ? A ARG 166 
18  1 Y 1 U ARG 167 ? A ARG 167 
19  1 Y 1 U ARG 168 ? A ARG 168 
20  1 Y 1 U GLY 169 ? A GLY 169 
21  1 Y 1 U ALA 170 ? A ALA 170 
22  1 Y 1 U LEU 171 ? A LEU 171 
23  1 Y 1 U PRO 172 ? A PRO 172 
24  1 Y 1 U GLN 173 ? A GLN 173 
25  1 Y 1 U GLU 174 ? A GLU 174 
26  1 Y 1 U SER 175 ? A SER 175 
27  1 Y 1 U LEU 176 ? A LEU 176 
28  1 Y 1 U LYS 177 ? A LYS 177 
29  1 Y 1 U ASP 178 ? A ASP 178 
30  1 Y 1 U ALA 179 ? A ALA 179 
31  1 Y 1 U GLY 180 ? A GLY 180 
32  1 Y 1 U GLN 181 ? A GLN 181 
33  1 Y 1 U CYS 182 ? A CYS 182 
34  1 Y 1 U GLU 183 ? A GLU 183 
35  1 Y 1 U VAL 184 ? A VAL 184 
36  1 Y 1 U ASP 185 ? A ASP 185 
37  1 Y 1 U SER 186 ? A SER 186 
38  1 Y 1 U LEU 187 ? A LEU 187 
39  1 Y 1 U SER 296 ? A SER 296 
40  1 Y 1 U GLY 297 ? A GLY 297 
41  1 Y 1 U CYS 298 ? A CYS 298 
42  1 Y 1 U CYS 299 ? A CYS 299 
43  1 Y 1 U PRO 300 ? A PRO 300 
44  1 Y 1 U GLN 301 ? A GLN 301 
45  1 Y 1 U CYS 302 ? A CYS 302 
46  1 Y 1 U GLN 303 ? A GLN 303 
47  1 Y 1 U ARG 304 ? A ARG 304 
48  1 Y 1 U GLY 305 ? A GLY 305 
49  1 Y 1 U LEU 306 ? A LEU 306 
50  1 Y 1 U LEU 307 ? A LEU 307 
51  1 Y 1 U ARG 308 ? A ARG 308 
52  1 Y 1 U SER 309 ? A SER 309 
53  1 Y 1 U ARG 310 ? A ARG 310 
54  1 Y 1 U ARG 311 ? A ARG 311 
55  1 Y 1 U ASN 312 ? A ASN 312 
56  1 Y 1 U VAL 313 ? A VAL 313 
57  1 Y 1 U VAL 314 ? A VAL 314 
58  1 Y 1 U MET 315 ? A MET 315 
59  1 Y 1 U PRO 316 ? A PRO 316 
60  1 Y 1 U GLY 317 ? A GLY 317 
61  1 Y 1 U SER 318 ? A SER 318 
62  1 Y 1 U VAL 319 ? A VAL 319 
63  1 Y 1 U ARG 320 ? A ARG 320 
64  1 Y 1 U ASN 321 ? A ASN 321 
65  1 Y 1 U ARG 322 ? A ARG 322 
66  1 Y 1 U CYS 323 ? A CYS 323 
67  1 Y 1 U ASN 324 ? A ASN 324 
68  1 Y 1 U ILE 325 ? A ILE 325 
69  1 Y 1 U SER 326 ? A SER 326 
70  1 Y 1 U ILE 327 ? A ILE 327 
71  1 Y 1 U GLU 328 ? A GLU 328 
72  1 Y 1 U THR 329 ? A THR 329 
73  1 Y 1 U ASP 330 ? A ASP 330 
74  1 Y 1 U GLY 331 ? A GLY 331 
75  1 Y 1 U VAL 332 ? A VAL 332 
76  1 Y 1 U ALA 333 ? A ALA 333 
77  1 Y 1 U GLU 334 ? A GLU 334 
78  1 Y 1 U SER 335 ? A SER 335 
79  1 Y 1 U ASP 336 ? A ASP 336 
80  1 Y 1 U THR 337 ? A THR 337 
81  1 Y 1 U ASP 338 ? A ASP 338 
82  1 Y 1 U GLY 339 ? A GLY 339 
83  1 Y 1 U ARG 340 ? A ARG 340 
84  1 Y 1 U ARG 341 ? A ARG 341 
85  1 Y 1 U LEU 342 ? A LEU 342 
86  1 Y 1 U SER 343 ? A SER 343 
87  1 Y 1 U GLY 344 ? A GLY 344 
88  1 Y 1 U GLU 345 ? A GLU 345 
89  1 Y 1 U MET 346 ? A MET 346 
90  1 Y 1 U ILE 347 ? A ILE 347 
91  1 Y 1 U SER 348 ? A SER 348 
92  1 Y 1 U MET 349 ? A MET 349 
93  1 Y 1 U LYS 350 ? A LYS 350 
94  1 Y 1 A MET 1   ? B MET 1   
95  1 Y 1 A ALA 2   ? B ALA 2   
96  1 Y 1 A GLY 3   ? B GLY 3   
97  1 Y 1 A ARG 4   ? B ARG 4   
98  1 Y 1 A GLY 5   ? B GLY 5   
99  1 Y 1 A PHE 6   ? B PHE 6   
100 1 Y 1 A SER 7   ? B SER 7   
101 1 Y 1 A TRP 8   ? B TRP 8   
102 1 Y 1 A GLY 9   ? B GLY 9   
103 1 Y 1 A PRO 10  ? B PRO 10  
104 1 Y 1 A GLY 11  ? B GLY 11  
105 1 Y 1 A HIS 12  ? B HIS 12  
106 1 Y 1 A LEU 13  ? B LEU 13  
107 1 Y 1 A ARG 163 ? B ARG 163 
108 1 Y 1 A GLN 164 ? B GLN 164 
109 1 Y 1 A LEU 165 ? B LEU 165 
110 1 Y 1 A ARG 166 ? B ARG 166 
111 1 Y 1 A ARG 167 ? B ARG 167 
112 1 Y 1 A ARG 168 ? B ARG 168 
113 1 Y 1 A GLY 169 ? B GLY 169 
114 1 Y 1 A ALA 170 ? B ALA 170 
115 1 Y 1 A LEU 171 ? B LEU 171 
116 1 Y 1 A PRO 172 ? B PRO 172 
117 1 Y 1 A GLN 173 ? B GLN 173 
118 1 Y 1 A GLU 174 ? B GLU 174 
119 1 Y 1 A SER 175 ? B SER 175 
120 1 Y 1 A LEU 176 ? B LEU 176 
121 1 Y 1 A LYS 177 ? B LYS 177 
122 1 Y 1 A ASP 178 ? B ASP 178 
123 1 Y 1 A ALA 179 ? B ALA 179 
124 1 Y 1 A GLY 180 ? B GLY 180 
125 1 Y 1 A GLN 181 ? B GLN 181 
126 1 Y 1 A CYS 182 ? B CYS 182 
127 1 Y 1 A GLU 183 ? B GLU 183 
128 1 Y 1 A VAL 184 ? B VAL 184 
129 1 Y 1 A ASP 185 ? B ASP 185 
130 1 Y 1 A SER 186 ? B SER 186 
131 1 Y 1 A LEU 187 ? B LEU 187 
132 1 Y 1 A SER 296 ? B SER 296 
133 1 Y 1 A GLY 297 ? B GLY 297 
134 1 Y 1 A CYS 298 ? B CYS 298 
135 1 Y 1 A CYS 299 ? B CYS 299 
136 1 Y 1 A PRO 300 ? B PRO 300 
137 1 Y 1 A GLN 301 ? B GLN 301 
138 1 Y 1 A CYS 302 ? B CYS 302 
139 1 Y 1 A GLN 303 ? B GLN 303 
140 1 Y 1 A ARG 304 ? B ARG 304 
141 1 Y 1 A GLY 305 ? B GLY 305 
142 1 Y 1 A LEU 306 ? B LEU 306 
143 1 Y 1 A LEU 307 ? B LEU 307 
144 1 Y 1 A ARG 308 ? B ARG 308 
145 1 Y 1 A SER 309 ? B SER 309 
146 1 Y 1 A ARG 310 ? B ARG 310 
147 1 Y 1 A ARG 311 ? B ARG 311 
148 1 Y 1 A ASN 312 ? B ASN 312 
149 1 Y 1 A VAL 313 ? B VAL 313 
150 1 Y 1 A VAL 314 ? B VAL 314 
151 1 Y 1 A MET 315 ? B MET 315 
152 1 Y 1 A PRO 316 ? B PRO 316 
153 1 Y 1 A GLY 317 ? B GLY 317 
154 1 Y 1 A SER 318 ? B SER 318 
155 1 Y 1 A VAL 319 ? B VAL 319 
156 1 Y 1 A ARG 320 ? B ARG 320 
157 1 Y 1 A ASN 321 ? B ASN 321 
158 1 Y 1 A ARG 322 ? B ARG 322 
159 1 Y 1 A CYS 323 ? B CYS 323 
160 1 Y 1 A ASN 324 ? B ASN 324 
161 1 Y 1 A ILE 325 ? B ILE 325 
162 1 Y 1 A SER 326 ? B SER 326 
163 1 Y 1 A ILE 327 ? B ILE 327 
164 1 Y 1 A GLU 328 ? B GLU 328 
165 1 Y 1 A THR 329 ? B THR 329 
166 1 Y 1 A ASP 330 ? B ASP 330 
167 1 Y 1 A GLY 331 ? B GLY 331 
168 1 Y 1 A VAL 332 ? B VAL 332 
169 1 Y 1 A ALA 333 ? B ALA 333 
170 1 Y 1 A GLU 334 ? B GLU 334 
171 1 Y 1 A SER 335 ? B SER 335 
172 1 Y 1 A ASP 336 ? B ASP 336 
173 1 Y 1 A THR 337 ? B THR 337 
174 1 Y 1 A ASP 338 ? B ASP 338 
175 1 Y 1 A GLY 339 ? B GLY 339 
176 1 Y 1 A ARG 340 ? B ARG 340 
177 1 Y 1 A ARG 341 ? B ARG 341 
178 1 Y 1 A LEU 342 ? B LEU 342 
179 1 Y 1 A SER 343 ? B SER 343 
180 1 Y 1 A GLY 344 ? B GLY 344 
181 1 Y 1 A GLU 345 ? B GLU 345 
182 1 Y 1 A MET 346 ? B MET 346 
183 1 Y 1 A ILE 347 ? B ILE 347 
184 1 Y 1 A SER 348 ? B SER 348 
185 1 Y 1 A MET 349 ? B MET 349 
186 1 Y 1 A LYS 350 ? B LYS 350 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
D10 C1   C N N 88  
D10 C2   C N N 89  
D10 C3   C N N 90  
D10 C4   C N N 91  
D10 C5   C N N 92  
D10 C6   C N N 93  
D10 C7   C N N 94  
D10 C8   C N N 95  
D10 C9   C N N 96  
D10 C10  C N N 97  
D10 H11  H N N 98  
D10 H12  H N N 99  
D10 H13  H N N 100 
D10 H21  H N N 101 
D10 H22  H N N 102 
D10 H31  H N N 103 
D10 H32  H N N 104 
D10 H41  H N N 105 
D10 H42  H N N 106 
D10 H51  H N N 107 
D10 H52  H N N 108 
D10 H61  H N N 109 
D10 H62  H N N 110 
D10 H71  H N N 111 
D10 H72  H N N 112 
D10 H81  H N N 113 
D10 H82  H N N 114 
D10 H91  H N N 115 
D10 H92  H N N 116 
D10 H101 H N N 117 
D10 H102 H N N 118 
D10 H103 H N N 119 
D12 C1   C N N 120 
D12 C2   C N N 121 
D12 C3   C N N 122 
D12 C4   C N N 123 
D12 C5   C N N 124 
D12 C6   C N N 125 
D12 C7   C N N 126 
D12 C8   C N N 127 
D12 C9   C N N 128 
D12 C10  C N N 129 
D12 C11  C N N 130 
D12 C12  C N N 131 
D12 H11  H N N 132 
D12 H12  H N N 133 
D12 H13  H N N 134 
D12 H21  H N N 135 
D12 H22  H N N 136 
D12 H31  H N N 137 
D12 H32  H N N 138 
D12 H41  H N N 139 
D12 H42  H N N 140 
D12 H51  H N N 141 
D12 H52  H N N 142 
D12 H61  H N N 143 
D12 H62  H N N 144 
D12 H71  H N N 145 
D12 H72  H N N 146 
D12 H81  H N N 147 
D12 H82  H N N 148 
D12 H91  H N N 149 
D12 H92  H N N 150 
D12 H101 H N N 151 
D12 H102 H N N 152 
D12 H111 H N N 153 
D12 H112 H N N 154 
D12 H121 H N N 155 
D12 H122 H N N 156 
D12 H123 H N N 157 
EIC C1   C N N 158 
EIC C2   C N N 159 
EIC C3   C N N 160 
EIC C4   C N N 161 
EIC C5   C N N 162 
EIC C6   C N N 163 
EIC C7   C N N 164 
EIC C8   C N N 165 
EIC C9   C N N 166 
EIC C10  C N N 167 
EIC C11  C N N 168 
EIC C12  C N N 169 
EIC C13  C N N 170 
EIC C14  C N N 171 
EIC C15  C N N 172 
EIC C16  C N N 173 
EIC C17  C N N 174 
EIC C18  C N N 175 
EIC O1   O N N 176 
EIC O2   O N N 177 
EIC H21  H N N 178 
EIC H22  H N N 179 
EIC H31  H N N 180 
EIC H32  H N N 181 
EIC H41  H N N 182 
EIC H42  H N N 183 
EIC H51  H N N 184 
EIC H52  H N N 185 
EIC H61  H N N 186 
EIC H62  H N N 187 
EIC H71  H N N 188 
EIC H72  H N N 189 
EIC H81  H N N 190 
EIC H82  H N N 191 
EIC H91  H N N 192 
EIC H1O1 H N N 193 
EIC H111 H N N 194 
EIC H112 H N N 195 
EIC H121 H N N 196 
EIC H131 H N N 197 
EIC H141 H N N 198 
EIC H142 H N N 199 
EIC H151 H N N 200 
EIC H152 H N N 201 
EIC H161 H N N 202 
EIC H162 H N N 203 
EIC H171 H N N 204 
EIC H172 H N N 205 
EIC H181 H N N 206 
EIC H182 H N N 207 
EIC H183 H N N 208 
EIC HO2  H N N 209 
GLN N    N N N 210 
GLN CA   C N S 211 
GLN C    C N N 212 
GLN O    O N N 213 
GLN CB   C N N 214 
GLN CG   C N N 215 
GLN CD   C N N 216 
GLN OE1  O N N 217 
GLN NE2  N N N 218 
GLN OXT  O N N 219 
GLN H    H N N 220 
GLN H2   H N N 221 
GLN HA   H N N 222 
GLN HB2  H N N 223 
GLN HB3  H N N 224 
GLN HG2  H N N 225 
GLN HG3  H N N 226 
GLN HE21 H N N 227 
GLN HE22 H N N 228 
GLN HXT  H N N 229 
GLU N    N N N 230 
GLU CA   C N S 231 
GLU C    C N N 232 
GLU O    O N N 233 
GLU CB   C N N 234 
GLU CG   C N N 235 
GLU CD   C N N 236 
GLU OE1  O N N 237 
GLU OE2  O N N 238 
GLU OXT  O N N 239 
GLU H    H N N 240 
GLU H2   H N N 241 
GLU HA   H N N 242 
GLU HB2  H N N 243 
GLU HB3  H N N 244 
GLU HG2  H N N 245 
GLU HG3  H N N 246 
GLU HE2  H N N 247 
GLU HXT  H N N 248 
GLY N    N N N 249 
GLY CA   C N N 250 
GLY C    C N N 251 
GLY O    O N N 252 
GLY OXT  O N N 253 
GLY H    H N N 254 
GLY H2   H N N 255 
GLY HA2  H N N 256 
GLY HA3  H N N 257 
GLY HXT  H N N 258 
HEX C1   C N N 259 
HEX C2   C N N 260 
HEX C3   C N N 261 
HEX C4   C N N 262 
HEX C5   C N N 263 
HEX C6   C N N 264 
HEX H11  H N N 265 
HEX H12  H N N 266 
HEX H13  H N N 267 
HEX H21  H N N 268 
HEX H22  H N N 269 
HEX H31  H N N 270 
HEX H32  H N N 271 
HEX H41  H N N 272 
HEX H42  H N N 273 
HEX H51  H N N 274 
HEX H52  H N N 275 
HEX H61  H N N 276 
HEX H62  H N N 277 
HEX H63  H N N 278 
HIS N    N N N 279 
HIS CA   C N S 280 
HIS C    C N N 281 
HIS O    O N N 282 
HIS CB   C N N 283 
HIS CG   C Y N 284 
HIS ND1  N Y N 285 
HIS CD2  C Y N 286 
HIS CE1  C Y N 287 
HIS NE2  N Y N 288 
HIS OXT  O N N 289 
HIS H    H N N 290 
HIS H2   H N N 291 
HIS HA   H N N 292 
HIS HB2  H N N 293 
HIS HB3  H N N 294 
HIS HD1  H N N 295 
HIS HD2  H N N 296 
HIS HE1  H N N 297 
HIS HE2  H N N 298 
HIS HXT  H N N 299 
ILE N    N N N 300 
ILE CA   C N S 301 
ILE C    C N N 302 
ILE O    O N N 303 
ILE CB   C N S 304 
ILE CG1  C N N 305 
ILE CG2  C N N 306 
ILE CD1  C N N 307 
ILE OXT  O N N 308 
ILE H    H N N 309 
ILE H2   H N N 310 
ILE HA   H N N 311 
ILE HB   H N N 312 
ILE HG12 H N N 313 
ILE HG13 H N N 314 
ILE HG21 H N N 315 
ILE HG22 H N N 316 
ILE HG23 H N N 317 
ILE HD11 H N N 318 
ILE HD12 H N N 319 
ILE HD13 H N N 320 
ILE HXT  H N N 321 
K   K    K N N 322 
LEU N    N N N 323 
LEU CA   C N S 324 
LEU C    C N N 325 
LEU O    O N N 326 
LEU CB   C N N 327 
LEU CG   C N N 328 
LEU CD1  C N N 329 
LEU CD2  C N N 330 
LEU OXT  O N N 331 
LEU H    H N N 332 
LEU H2   H N N 333 
LEU HA   H N N 334 
LEU HB2  H N N 335 
LEU HB3  H N N 336 
LEU HG   H N N 337 
LEU HD11 H N N 338 
LEU HD12 H N N 339 
LEU HD13 H N N 340 
LEU HD21 H N N 341 
LEU HD22 H N N 342 
LEU HD23 H N N 343 
LEU HXT  H N N 344 
LYS N    N N N 345 
LYS CA   C N S 346 
LYS C    C N N 347 
LYS O    O N N 348 
LYS CB   C N N 349 
LYS CG   C N N 350 
LYS CD   C N N 351 
LYS CE   C N N 352 
LYS NZ   N N N 353 
LYS OXT  O N N 354 
LYS H    H N N 355 
LYS H2   H N N 356 
LYS HA   H N N 357 
LYS HB2  H N N 358 
LYS HB3  H N N 359 
LYS HG2  H N N 360 
LYS HG3  H N N 361 
LYS HD2  H N N 362 
LYS HD3  H N N 363 
LYS HE2  H N N 364 
LYS HE3  H N N 365 
LYS HZ1  H N N 366 
LYS HZ2  H N N 367 
LYS HZ3  H N N 368 
LYS HXT  H N N 369 
MET N    N N N 370 
MET CA   C N S 371 
MET C    C N N 372 
MET O    O N N 373 
MET CB   C N N 374 
MET CG   C N N 375 
MET SD   S N N 376 
MET CE   C N N 377 
MET OXT  O N N 378 
MET H    H N N 379 
MET H2   H N N 380 
MET HA   H N N 381 
MET HB2  H N N 382 
MET HB3  H N N 383 
MET HG2  H N N 384 
MET HG3  H N N 385 
MET HE1  H N N 386 
MET HE2  H N N 387 
MET HE3  H N N 388 
MET HXT  H N N 389 
OCT C1   C N N 390 
OCT C2   C N N 391 
OCT C3   C N N 392 
OCT C4   C N N 393 
OCT C5   C N N 394 
OCT C6   C N N 395 
OCT C7   C N N 396 
OCT C8   C N N 397 
OCT H11  H N N 398 
OCT H12  H N N 399 
OCT H13  H N N 400 
OCT H21  H N N 401 
OCT H22  H N N 402 
OCT H31  H N N 403 
OCT H32  H N N 404 
OCT H41  H N N 405 
OCT H42  H N N 406 
OCT H51  H N N 407 
OCT H52  H N N 408 
OCT H61  H N N 409 
OCT H62  H N N 410 
OCT H71  H N N 411 
OCT H72  H N N 412 
OCT H81  H N N 413 
OCT H82  H N N 414 
OCT H83  H N N 415 
PHE N    N N N 416 
PHE CA   C N S 417 
PHE C    C N N 418 
PHE O    O N N 419 
PHE CB   C N N 420 
PHE CG   C Y N 421 
PHE CD1  C Y N 422 
PHE CD2  C Y N 423 
PHE CE1  C Y N 424 
PHE CE2  C Y N 425 
PHE CZ   C Y N 426 
PHE OXT  O N N 427 
PHE H    H N N 428 
PHE H2   H N N 429 
PHE HA   H N N 430 
PHE HB2  H N N 431 
PHE HB3  H N N 432 
PHE HD1  H N N 433 
PHE HD2  H N N 434 
PHE HE1  H N N 435 
PHE HE2  H N N 436 
PHE HZ   H N N 437 
PHE HXT  H N N 438 
PRO N    N N N 439 
PRO CA   C N S 440 
PRO C    C N N 441 
PRO O    O N N 442 
PRO CB   C N N 443 
PRO CG   C N N 444 
PRO CD   C N N 445 
PRO OXT  O N N 446 
PRO H    H N N 447 
PRO HA   H N N 448 
PRO HB2  H N N 449 
PRO HB3  H N N 450 
PRO HG2  H N N 451 
PRO HG3  H N N 452 
PRO HD2  H N N 453 
PRO HD3  H N N 454 
PRO HXT  H N N 455 
SER N    N N N 456 
SER CA   C N S 457 
SER C    C N N 458 
SER O    O N N 459 
SER CB   C N N 460 
SER OG   O N N 461 
SER OXT  O N N 462 
SER H    H N N 463 
SER H2   H N N 464 
SER HA   H N N 465 
SER HB2  H N N 466 
SER HB3  H N N 467 
SER HG   H N N 468 
SER HXT  H N N 469 
THR N    N N N 470 
THR CA   C N S 471 
THR C    C N N 472 
THR O    O N N 473 
THR CB   C N R 474 
THR OG1  O N N 475 
THR CG2  C N N 476 
THR OXT  O N N 477 
THR H    H N N 478 
THR H2   H N N 479 
THR HA   H N N 480 
THR HB   H N N 481 
THR HG1  H N N 482 
THR HG21 H N N 483 
THR HG22 H N N 484 
THR HG23 H N N 485 
THR HXT  H N N 486 
TRP N    N N N 487 
TRP CA   C N S 488 
TRP C    C N N 489 
TRP O    O N N 490 
TRP CB   C N N 491 
TRP CG   C Y N 492 
TRP CD1  C Y N 493 
TRP CD2  C Y N 494 
TRP NE1  N Y N 495 
TRP CE2  C Y N 496 
TRP CE3  C Y N 497 
TRP CZ2  C Y N 498 
TRP CZ3  C Y N 499 
TRP CH2  C Y N 500 
TRP OXT  O N N 501 
TRP H    H N N 502 
TRP H2   H N N 503 
TRP HA   H N N 504 
TRP HB2  H N N 505 
TRP HB3  H N N 506 
TRP HD1  H N N 507 
TRP HE1  H N N 508 
TRP HE3  H N N 509 
TRP HZ2  H N N 510 
TRP HZ3  H N N 511 
TRP HH2  H N N 512 
TRP HXT  H N N 513 
TYR N    N N N 514 
TYR CA   C N S 515 
TYR C    C N N 516 
TYR O    O N N 517 
TYR CB   C N N 518 
TYR CG   C Y N 519 
TYR CD1  C Y N 520 
TYR CD2  C Y N 521 
TYR CE1  C Y N 522 
TYR CE2  C Y N 523 
TYR CZ   C Y N 524 
TYR OH   O N N 525 
TYR OXT  O N N 526 
TYR H    H N N 527 
TYR H2   H N N 528 
TYR HA   H N N 529 
TYR HB2  H N N 530 
TYR HB3  H N N 531 
TYR HD1  H N N 532 
TYR HD2  H N N 533 
TYR HE1  H N N 534 
TYR HE2  H N N 535 
TYR HH   H N N 536 
TYR HXT  H N N 537 
VAL N    N N N 538 
VAL CA   C N S 539 
VAL C    C N N 540 
VAL O    O N N 541 
VAL CB   C N N 542 
VAL CG1  C N N 543 
VAL CG2  C N N 544 
VAL OXT  O N N 545 
VAL H    H N N 546 
VAL H2   H N N 547 
VAL HA   H N N 548 
VAL HB   H N N 549 
VAL HG11 H N N 550 
VAL HG12 H N N 551 
VAL HG13 H N N 552 
VAL HG21 H N N 553 
VAL HG22 H N N 554 
VAL HG23 H N N 555 
VAL HXT  H N N 556 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
D10 C1  C2   sing N N 83  
D10 C1  H11  sing N N 84  
D10 C1  H12  sing N N 85  
D10 C1  H13  sing N N 86  
D10 C2  C3   sing N N 87  
D10 C2  H21  sing N N 88  
D10 C2  H22  sing N N 89  
D10 C3  C4   sing N N 90  
D10 C3  H31  sing N N 91  
D10 C3  H32  sing N N 92  
D10 C4  C5   sing N N 93  
D10 C4  H41  sing N N 94  
D10 C4  H42  sing N N 95  
D10 C5  C6   sing N N 96  
D10 C5  H51  sing N N 97  
D10 C5  H52  sing N N 98  
D10 C6  C7   sing N N 99  
D10 C6  H61  sing N N 100 
D10 C6  H62  sing N N 101 
D10 C7  C8   sing N N 102 
D10 C7  H71  sing N N 103 
D10 C7  H72  sing N N 104 
D10 C8  C9   sing N N 105 
D10 C8  H81  sing N N 106 
D10 C8  H82  sing N N 107 
D10 C9  C10  sing N N 108 
D10 C9  H91  sing N N 109 
D10 C9  H92  sing N N 110 
D10 C10 H101 sing N N 111 
D10 C10 H102 sing N N 112 
D10 C10 H103 sing N N 113 
D12 C1  C2   sing N N 114 
D12 C1  H11  sing N N 115 
D12 C1  H12  sing N N 116 
D12 C1  H13  sing N N 117 
D12 C2  C3   sing N N 118 
D12 C2  H21  sing N N 119 
D12 C2  H22  sing N N 120 
D12 C3  C4   sing N N 121 
D12 C3  H31  sing N N 122 
D12 C3  H32  sing N N 123 
D12 C4  C5   sing N N 124 
D12 C4  H41  sing N N 125 
D12 C4  H42  sing N N 126 
D12 C5  C6   sing N N 127 
D12 C5  H51  sing N N 128 
D12 C5  H52  sing N N 129 
D12 C6  C7   sing N N 130 
D12 C6  H61  sing N N 131 
D12 C6  H62  sing N N 132 
D12 C7  C8   sing N N 133 
D12 C7  H71  sing N N 134 
D12 C7  H72  sing N N 135 
D12 C8  C9   sing N N 136 
D12 C8  H81  sing N N 137 
D12 C8  H82  sing N N 138 
D12 C9  C10  sing N N 139 
D12 C9  H91  sing N N 140 
D12 C9  H92  sing N N 141 
D12 C10 C11  sing N N 142 
D12 C10 H101 sing N N 143 
D12 C10 H102 sing N N 144 
D12 C11 C12  sing N N 145 
D12 C11 H111 sing N N 146 
D12 C11 H112 sing N N 147 
D12 C12 H121 sing N N 148 
D12 C12 H122 sing N N 149 
D12 C12 H123 sing N N 150 
EIC C1  C2   sing N N 151 
EIC C1  O1   doub N N 152 
EIC C1  O2   sing N N 153 
EIC C2  C3   sing N N 154 
EIC C2  H21  sing N N 155 
EIC C2  H22  sing N N 156 
EIC C3  C4   sing N N 157 
EIC C3  H31  sing N N 158 
EIC C3  H32  sing N N 159 
EIC C4  C5   sing N N 160 
EIC C4  H41  sing N N 161 
EIC C4  H42  sing N N 162 
EIC C5  C6   sing N N 163 
EIC C5  H51  sing N N 164 
EIC C5  H52  sing N N 165 
EIC C6  C7   sing N N 166 
EIC C6  H61  sing N N 167 
EIC C6  H62  sing N N 168 
EIC C7  C8   sing N N 169 
EIC C7  H71  sing N N 170 
EIC C7  H72  sing N N 171 
EIC C8  C9   sing N N 172 
EIC C8  H81  sing N N 173 
EIC C8  H82  sing N N 174 
EIC C9  C10  doub N Z 175 
EIC C9  H91  sing N N 176 
EIC C10 C11  sing N N 177 
EIC C10 H1O1 sing N N 178 
EIC C11 C12  sing N N 179 
EIC C11 H111 sing N N 180 
EIC C11 H112 sing N N 181 
EIC C12 C13  doub N Z 182 
EIC C12 H121 sing N N 183 
EIC C13 C14  sing N N 184 
EIC C13 H131 sing N N 185 
EIC C14 C15  sing N N 186 
EIC C14 H141 sing N N 187 
EIC C14 H142 sing N N 188 
EIC C15 C16  sing N N 189 
EIC C15 H151 sing N N 190 
EIC C15 H152 sing N N 191 
EIC C16 C17  sing N N 192 
EIC C16 H161 sing N N 193 
EIC C16 H162 sing N N 194 
EIC C17 C18  sing N N 195 
EIC C17 H171 sing N N 196 
EIC C17 H172 sing N N 197 
EIC C18 H181 sing N N 198 
EIC C18 H182 sing N N 199 
EIC C18 H183 sing N N 200 
EIC O2  HO2  sing N N 201 
GLN N   CA   sing N N 202 
GLN N   H    sing N N 203 
GLN N   H2   sing N N 204 
GLN CA  C    sing N N 205 
GLN CA  CB   sing N N 206 
GLN CA  HA   sing N N 207 
GLN C   O    doub N N 208 
GLN C   OXT  sing N N 209 
GLN CB  CG   sing N N 210 
GLN CB  HB2  sing N N 211 
GLN CB  HB3  sing N N 212 
GLN CG  CD   sing N N 213 
GLN CG  HG2  sing N N 214 
GLN CG  HG3  sing N N 215 
GLN CD  OE1  doub N N 216 
GLN CD  NE2  sing N N 217 
GLN NE2 HE21 sing N N 218 
GLN NE2 HE22 sing N N 219 
GLN OXT HXT  sing N N 220 
GLU N   CA   sing N N 221 
GLU N   H    sing N N 222 
GLU N   H2   sing N N 223 
GLU CA  C    sing N N 224 
GLU CA  CB   sing N N 225 
GLU CA  HA   sing N N 226 
GLU C   O    doub N N 227 
GLU C   OXT  sing N N 228 
GLU CB  CG   sing N N 229 
GLU CB  HB2  sing N N 230 
GLU CB  HB3  sing N N 231 
GLU CG  CD   sing N N 232 
GLU CG  HG2  sing N N 233 
GLU CG  HG3  sing N N 234 
GLU CD  OE1  doub N N 235 
GLU CD  OE2  sing N N 236 
GLU OE2 HE2  sing N N 237 
GLU OXT HXT  sing N N 238 
GLY N   CA   sing N N 239 
GLY N   H    sing N N 240 
GLY N   H2   sing N N 241 
GLY CA  C    sing N N 242 
GLY CA  HA2  sing N N 243 
GLY CA  HA3  sing N N 244 
GLY C   O    doub N N 245 
GLY C   OXT  sing N N 246 
GLY OXT HXT  sing N N 247 
HEX C1  C2   sing N N 248 
HEX C1  H11  sing N N 249 
HEX C1  H12  sing N N 250 
HEX C1  H13  sing N N 251 
HEX C2  C3   sing N N 252 
HEX C2  H21  sing N N 253 
HEX C2  H22  sing N N 254 
HEX C3  C4   sing N N 255 
HEX C3  H31  sing N N 256 
HEX C3  H32  sing N N 257 
HEX C4  C5   sing N N 258 
HEX C4  H41  sing N N 259 
HEX C4  H42  sing N N 260 
HEX C5  C6   sing N N 261 
HEX C5  H51  sing N N 262 
HEX C5  H52  sing N N 263 
HEX C6  H61  sing N N 264 
HEX C6  H62  sing N N 265 
HEX C6  H63  sing N N 266 
HIS N   CA   sing N N 267 
HIS N   H    sing N N 268 
HIS N   H2   sing N N 269 
HIS CA  C    sing N N 270 
HIS CA  CB   sing N N 271 
HIS CA  HA   sing N N 272 
HIS C   O    doub N N 273 
HIS C   OXT  sing N N 274 
HIS CB  CG   sing N N 275 
HIS CB  HB2  sing N N 276 
HIS CB  HB3  sing N N 277 
HIS CG  ND1  sing Y N 278 
HIS CG  CD2  doub Y N 279 
HIS ND1 CE1  doub Y N 280 
HIS ND1 HD1  sing N N 281 
HIS CD2 NE2  sing Y N 282 
HIS CD2 HD2  sing N N 283 
HIS CE1 NE2  sing Y N 284 
HIS CE1 HE1  sing N N 285 
HIS NE2 HE2  sing N N 286 
HIS OXT HXT  sing N N 287 
ILE N   CA   sing N N 288 
ILE N   H    sing N N 289 
ILE N   H2   sing N N 290 
ILE CA  C    sing N N 291 
ILE CA  CB   sing N N 292 
ILE CA  HA   sing N N 293 
ILE C   O    doub N N 294 
ILE C   OXT  sing N N 295 
ILE CB  CG1  sing N N 296 
ILE CB  CG2  sing N N 297 
ILE CB  HB   sing N N 298 
ILE CG1 CD1  sing N N 299 
ILE CG1 HG12 sing N N 300 
ILE CG1 HG13 sing N N 301 
ILE CG2 HG21 sing N N 302 
ILE CG2 HG22 sing N N 303 
ILE CG2 HG23 sing N N 304 
ILE CD1 HD11 sing N N 305 
ILE CD1 HD12 sing N N 306 
ILE CD1 HD13 sing N N 307 
ILE OXT HXT  sing N N 308 
LEU N   CA   sing N N 309 
LEU N   H    sing N N 310 
LEU N   H2   sing N N 311 
LEU CA  C    sing N N 312 
LEU CA  CB   sing N N 313 
LEU CA  HA   sing N N 314 
LEU C   O    doub N N 315 
LEU C   OXT  sing N N 316 
LEU CB  CG   sing N N 317 
LEU CB  HB2  sing N N 318 
LEU CB  HB3  sing N N 319 
LEU CG  CD1  sing N N 320 
LEU CG  CD2  sing N N 321 
LEU CG  HG   sing N N 322 
LEU CD1 HD11 sing N N 323 
LEU CD1 HD12 sing N N 324 
LEU CD1 HD13 sing N N 325 
LEU CD2 HD21 sing N N 326 
LEU CD2 HD22 sing N N 327 
LEU CD2 HD23 sing N N 328 
LEU OXT HXT  sing N N 329 
LYS N   CA   sing N N 330 
LYS N   H    sing N N 331 
LYS N   H2   sing N N 332 
LYS CA  C    sing N N 333 
LYS CA  CB   sing N N 334 
LYS CA  HA   sing N N 335 
LYS C   O    doub N N 336 
LYS C   OXT  sing N N 337 
LYS CB  CG   sing N N 338 
LYS CB  HB2  sing N N 339 
LYS CB  HB3  sing N N 340 
LYS CG  CD   sing N N 341 
LYS CG  HG2  sing N N 342 
LYS CG  HG3  sing N N 343 
LYS CD  CE   sing N N 344 
LYS CD  HD2  sing N N 345 
LYS CD  HD3  sing N N 346 
LYS CE  NZ   sing N N 347 
LYS CE  HE2  sing N N 348 
LYS CE  HE3  sing N N 349 
LYS NZ  HZ1  sing N N 350 
LYS NZ  HZ2  sing N N 351 
LYS NZ  HZ3  sing N N 352 
LYS OXT HXT  sing N N 353 
MET N   CA   sing N N 354 
MET N   H    sing N N 355 
MET N   H2   sing N N 356 
MET CA  C    sing N N 357 
MET CA  CB   sing N N 358 
MET CA  HA   sing N N 359 
MET C   O    doub N N 360 
MET C   OXT  sing N N 361 
MET CB  CG   sing N N 362 
MET CB  HB2  sing N N 363 
MET CB  HB3  sing N N 364 
MET CG  SD   sing N N 365 
MET CG  HG2  sing N N 366 
MET CG  HG3  sing N N 367 
MET SD  CE   sing N N 368 
MET CE  HE1  sing N N 369 
MET CE  HE2  sing N N 370 
MET CE  HE3  sing N N 371 
MET OXT HXT  sing N N 372 
OCT C1  C2   sing N N 373 
OCT C1  H11  sing N N 374 
OCT C1  H12  sing N N 375 
OCT C1  H13  sing N N 376 
OCT C2  C3   sing N N 377 
OCT C2  H21  sing N N 378 
OCT C2  H22  sing N N 379 
OCT C3  C4   sing N N 380 
OCT C3  H31  sing N N 381 
OCT C3  H32  sing N N 382 
OCT C4  C5   sing N N 383 
OCT C4  H41  sing N N 384 
OCT C4  H42  sing N N 385 
OCT C5  C6   sing N N 386 
OCT C5  H51  sing N N 387 
OCT C5  H52  sing N N 388 
OCT C6  C7   sing N N 389 
OCT C6  H61  sing N N 390 
OCT C6  H62  sing N N 391 
OCT C7  C8   sing N N 392 
OCT C7  H71  sing N N 393 
OCT C7  H72  sing N N 394 
OCT C8  H81  sing N N 395 
OCT C8  H82  sing N N 396 
OCT C8  H83  sing N N 397 
PHE N   CA   sing N N 398 
PHE N   H    sing N N 399 
PHE N   H2   sing N N 400 
PHE CA  C    sing N N 401 
PHE CA  CB   sing N N 402 
PHE CA  HA   sing N N 403 
PHE C   O    doub N N 404 
PHE C   OXT  sing N N 405 
PHE CB  CG   sing N N 406 
PHE CB  HB2  sing N N 407 
PHE CB  HB3  sing N N 408 
PHE CG  CD1  doub Y N 409 
PHE CG  CD2  sing Y N 410 
PHE CD1 CE1  sing Y N 411 
PHE CD1 HD1  sing N N 412 
PHE CD2 CE2  doub Y N 413 
PHE CD2 HD2  sing N N 414 
PHE CE1 CZ   doub Y N 415 
PHE CE1 HE1  sing N N 416 
PHE CE2 CZ   sing Y N 417 
PHE CE2 HE2  sing N N 418 
PHE CZ  HZ   sing N N 419 
PHE OXT HXT  sing N N 420 
PRO N   CA   sing N N 421 
PRO N   CD   sing N N 422 
PRO N   H    sing N N 423 
PRO CA  C    sing N N 424 
PRO CA  CB   sing N N 425 
PRO CA  HA   sing N N 426 
PRO C   O    doub N N 427 
PRO C   OXT  sing N N 428 
PRO CB  CG   sing N N 429 
PRO CB  HB2  sing N N 430 
PRO CB  HB3  sing N N 431 
PRO CG  CD   sing N N 432 
PRO CG  HG2  sing N N 433 
PRO CG  HG3  sing N N 434 
PRO CD  HD2  sing N N 435 
PRO CD  HD3  sing N N 436 
PRO OXT HXT  sing N N 437 
SER N   CA   sing N N 438 
SER N   H    sing N N 439 
SER N   H2   sing N N 440 
SER CA  C    sing N N 441 
SER CA  CB   sing N N 442 
SER CA  HA   sing N N 443 
SER C   O    doub N N 444 
SER C   OXT  sing N N 445 
SER CB  OG   sing N N 446 
SER CB  HB2  sing N N 447 
SER CB  HB3  sing N N 448 
SER OG  HG   sing N N 449 
SER OXT HXT  sing N N 450 
THR N   CA   sing N N 451 
THR N   H    sing N N 452 
THR N   H2   sing N N 453 
THR CA  C    sing N N 454 
THR CA  CB   sing N N 455 
THR CA  HA   sing N N 456 
THR C   O    doub N N 457 
THR C   OXT  sing N N 458 
THR CB  OG1  sing N N 459 
THR CB  CG2  sing N N 460 
THR CB  HB   sing N N 461 
THR OG1 HG1  sing N N 462 
THR CG2 HG21 sing N N 463 
THR CG2 HG22 sing N N 464 
THR CG2 HG23 sing N N 465 
THR OXT HXT  sing N N 466 
TRP N   CA   sing N N 467 
TRP N   H    sing N N 468 
TRP N   H2   sing N N 469 
TRP CA  C    sing N N 470 
TRP CA  CB   sing N N 471 
TRP CA  HA   sing N N 472 
TRP C   O    doub N N 473 
TRP C   OXT  sing N N 474 
TRP CB  CG   sing N N 475 
TRP CB  HB2  sing N N 476 
TRP CB  HB3  sing N N 477 
TRP CG  CD1  doub Y N 478 
TRP CG  CD2  sing Y N 479 
TRP CD1 NE1  sing Y N 480 
TRP CD1 HD1  sing N N 481 
TRP CD2 CE2  doub Y N 482 
TRP CD2 CE3  sing Y N 483 
TRP NE1 CE2  sing Y N 484 
TRP NE1 HE1  sing N N 485 
TRP CE2 CZ2  sing Y N 486 
TRP CE3 CZ3  doub Y N 487 
TRP CE3 HE3  sing N N 488 
TRP CZ2 CH2  doub Y N 489 
TRP CZ2 HZ2  sing N N 490 
TRP CZ3 CH2  sing Y N 491 
TRP CZ3 HZ3  sing N N 492 
TRP CH2 HH2  sing N N 493 
TRP OXT HXT  sing N N 494 
TYR N   CA   sing N N 495 
TYR N   H    sing N N 496 
TYR N   H2   sing N N 497 
TYR CA  C    sing N N 498 
TYR CA  CB   sing N N 499 
TYR CA  HA   sing N N 500 
TYR C   O    doub N N 501 
TYR C   OXT  sing N N 502 
TYR CB  CG   sing N N 503 
TYR CB  HB2  sing N N 504 
TYR CB  HB3  sing N N 505 
TYR CG  CD1  doub Y N 506 
TYR CG  CD2  sing Y N 507 
TYR CD1 CE1  sing Y N 508 
TYR CD1 HD1  sing N N 509 
TYR CD2 CE2  doub Y N 510 
TYR CD2 HD2  sing N N 511 
TYR CE1 CZ   doub Y N 512 
TYR CE1 HE1  sing N N 513 
TYR CE2 CZ   sing Y N 514 
TYR CE2 HE2  sing N N 515 
TYR CZ  OH   sing N N 516 
TYR OH  HH   sing N N 517 
TYR OXT HXT  sing N N 518 
VAL N   CA   sing N N 519 
VAL N   H    sing N N 520 
VAL N   H2   sing N N 521 
VAL CA  C    sing N N 522 
VAL CA  CB   sing N N 523 
VAL CA  HA   sing N N 524 
VAL C   O    doub N N 525 
VAL C   OXT  sing N N 526 
VAL CB  CG1  sing N N 527 
VAL CB  CG2  sing N N 528 
VAL CB  HB   sing N N 529 
VAL CG1 HG11 sing N N 530 
VAL CG1 HG12 sing N N 531 
VAL CG1 HG13 sing N N 532 
VAL CG2 HG21 sing N N 533 
VAL CG2 HG22 sing N N 534 
VAL CG2 HG23 sing N N 535 
VAL OXT HXT  sing N N 536 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-05-21 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           9BWS 
_em_admin.last_update        2025-03-12 
_em_admin.map_release_date   2025-02-26 
_em_admin.title              'Structure of human k2P13.1 (THIK-1) S136P Y273A in lipid nanodisc' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     NONE 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                ? 
_em_entity_assembly_molwt.value                ? 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         46 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? ?         ?   
'IMAGE ACQUISITION'             ? 2  ? ? 1 ?         ?   
MASKING                         ? 3  ? ? ? ?         ?   
'CTF CORRECTION'                ? 4  1 ? ? ?         ?   
'LAYERLINE INDEXING'            ? 5  ? ? ? ?         ?   
'DIFFRACTION INDEXING'          ? 6  ? ? ? ?         ?   
'MODEL FITTING'                 ? 7  ? ? ? ?         ?   
'MODEL REFINEMENT'              ? 8  ? ? ? ?         ?   
OTHER                           ? 9  ? ? ? ?         ?   
'INITIAL EULER ASSIGNMENT'      ? 10 1 ? ? ?         ?   
'FINAL EULER ASSIGNMENT'        ? 11 1 ? ? ?         ?   
CLASSIFICATION                  ? 12 1 ? ? ?         ?   
RECONSTRUCTION                  ? 13 1 ? ? cryoSPARC 3.2 
'VOLUME SELECTION'              ? 14 1 1 1 ?         ?   
'SERIES ALIGNMENT'              ? 15 1 1 1 ?         ?   
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ?         ?   
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ?         ?   
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ?         ?   
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ?         ?   
# 
_em_specimen.concentration           1 
_em_specimen.details                 'mutant protein in lipid nanodisc' 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'National Institutes of Health/National Institute of Mental Health (NIH/NIMH)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           'R01 MH093603' 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    9BWS 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
H 
K 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . ASN A 1 14  ? 108.270 102.900 143.199 1.00 48.27  ? 14  ASN U N    1 
ATOM   2    C CA   . ASN A 1 14  ? 107.243 102.582 142.213 1.00 49.40  ? 14  ASN U CA   1 
ATOM   3    C C    . ASN A 1 14  ? 106.681 103.850 141.578 1.00 52.70  ? 14  ASN U C    1 
ATOM   4    O O    . ASN A 1 14  ? 106.147 103.814 140.467 1.00 55.80  ? 14  ASN U O    1 
ATOM   5    C CB   . ASN A 1 14  ? 106.116 101.775 142.860 1.00 48.97  ? 14  ASN U CB   1 
ATOM   6    C CG   . ASN A 1 14  ? 105.216 101.109 141.838 1.00 50.85  ? 14  ASN U CG   1 
ATOM   7    O OD1  . ASN A 1 14  ? 105.575 100.971 140.670 1.00 54.21  ? 14  ASN U OD1  1 
ATOM   8    N ND2  . ASN A 1 14  ? 104.036 100.688 142.277 1.00 48.60  ? 14  ASN U ND2  1 
ATOM   9    N N    . GLU A 1 15  ? 106.809 104.971 142.289 1.00 52.15  ? 15  GLU U N    1 
ATOM   10   C CA   . GLU A 1 15  ? 106.365 106.250 141.742 1.00 50.18  ? 15  GLU U CA   1 
ATOM   11   C C    . GLU A 1 15  ? 107.214 106.676 140.550 1.00 55.43  ? 15  GLU U C    1 
ATOM   12   O O    . GLU A 1 15  ? 106.682 107.173 139.549 1.00 58.18  ? 15  GLU U O    1 
ATOM   13   C CB   . GLU A 1 15  ? 106.396 107.320 142.834 1.00 50.79  ? 15  GLU U CB   1 
ATOM   14   C CG   . GLU A 1 15  ? 105.924 108.688 142.382 1.00 57.29  ? 15  GLU U CG   1 
ATOM   15   C CD   . GLU A 1 15  ? 105.788 109.666 143.534 1.00 64.07  ? 15  GLU U CD   1 
ATOM   16   O OE1  . GLU A 1 15  ? 105.883 109.228 144.701 1.00 61.66  ? 15  GLU U OE1  1 
ATOM   17   O OE2  . GLU A 1 15  ? 105.584 110.869 143.274 1.00 61.07  ? 15  GLU U OE2  1 
ATOM   18   N N    . ASP A 1 16  ? 108.534 106.490 140.636 1.00 48.98  ? 16  ASP U N    1 
ATOM   19   C CA   . ASP A 1 16  ? 109.407 106.872 139.533 1.00 45.37  ? 16  ASP U CA   1 
ATOM   20   C C    . ASP A 1 16  ? 109.135 106.037 138.287 1.00 49.30  ? 16  ASP U C    1 
ATOM   21   O O    . ASP A 1 16  ? 109.088 106.571 137.170 1.00 52.79  ? 16  ASP U O    1 
ATOM   22   C CB   . ASP A 1 16  ? 110.870 106.738 139.957 1.00 46.82  ? 16  ASP U CB   1 
ATOM   23   C CG   . ASP A 1 16  ? 111.210 107.597 141.160 1.00 54.45  ? 16  ASP U CG   1 
ATOM   24   O OD1  . ASP A 1 16  ? 110.586 108.669 141.319 1.00 60.31  ? 16  ASP U OD1  1 
ATOM   25   O OD2  . ASP A 1 16  ? 112.094 107.203 141.943 1.00 54.88  ? 16  ASP U OD2  1 
ATOM   26   N N    . ASN A 1 17  ? 108.950 104.726 138.456 1.00 42.19  ? 17  ASN U N    1 
ATOM   27   C CA   . ASN A 1 17  ? 108.633 103.867 137.317 1.00 43.07  ? 17  ASN U CA   1 
ATOM   28   C C    . ASN A 1 17  ? 107.293 104.245 136.697 1.00 44.88  ? 17  ASN U C    1 
ATOM   29   O O    . ASN A 1 17  ? 107.153 104.276 135.468 1.00 47.13  ? 17  ASN U O    1 
ATOM   30   C CB   . ASN A 1 17  ? 108.631 102.404 137.748 1.00 44.14  ? 17  ASN U CB   1 
ATOM   31   C CG   . ASN A 1 17  ? 109.958 101.966 138.337 1.00 48.51  ? 17  ASN U CG   1 
ATOM   32   O OD1  . ASN A 1 17  ? 110.996 102.575 138.078 1.00 49.95  ? 17  ASN U OD1  1 
ATOM   33   N ND2  . ASN A 1 17  ? 109.931 100.904 139.130 1.00 49.95  ? 17  ASN U ND2  1 
ATOM   34   N N    . ALA A 1 18  ? 106.294 104.530 137.535 1.00 38.76  ? 18  ALA U N    1 
ATOM   35   C CA   . ALA A 1 18  ? 104.988 104.933 137.026 1.00 38.06  ? 18  ALA U CA   1 
ATOM   36   C C    . ALA A 1 18  ? 105.079 106.238 136.247 1.00 39.81  ? 18  ALA U C    1 
ATOM   37   O O    . ALA A 1 18  ? 104.467 106.379 135.183 1.00 42.67  ? 18  ALA U O    1 
ATOM   38   C CB   . ALA A 1 18  ? 103.992 105.061 138.178 1.00 33.74  ? 18  ALA U CB   1 
ATOM   39   N N    . ARG A 1 19  ? 105.838 107.205 136.764 1.00 34.63  ? 19  ARG U N    1 
ATOM   40   C CA   . ARG A 1 19  ? 106.003 108.477 136.066 1.00 30.87  ? 19  ARG U CA   1 
ATOM   41   C C    . ARG A 1 19  ? 106.725 108.288 134.738 1.00 34.61  ? 19  ARG U C    1 
ATOM   42   O O    . ARG A 1 19  ? 106.343 108.889 133.724 1.00 42.85  ? 19  ARG U O    1 
ATOM   43   C CB   . ARG A 1 19  ? 106.752 109.460 136.966 1.00 31.42  ? 19  ARG U CB   1 
ATOM   44   C CG   . ARG A 1 19  ? 107.279 110.699 136.267 1.00 37.38  ? 19  ARG U CG   1 
ATOM   45   C CD   . ARG A 1 19  ? 107.501 111.826 137.263 1.00 36.51  ? 19  ARG U CD   1 
ATOM   46   N NE   . ARG A 1 19  ? 108.708 111.622 138.052 1.00 36.86  ? 19  ARG U NE   1 
ATOM   47   C CZ   . ARG A 1 19  ? 108.719 111.432 139.365 1.00 37.54  ? 19  ARG U CZ   1 
ATOM   48   N NH1  . ARG A 1 19  ? 107.601 111.430 140.071 1.00 34.74  ? 19  ARG U NH1  1 
ATOM   49   N NH2  . ARG A 1 19  ? 109.880 111.243 139.984 1.00 40.47  ? 19  ARG U NH2  1 
ATOM   50   N N    . PHE A 1 20  ? 107.756 107.444 134.721 1.00 29.70  ? 20  PHE U N    1 
ATOM   51   C CA   . PHE A 1 20  ? 108.478 107.153 133.484 1.00 26.81  ? 20  PHE U CA   1 
ATOM   52   C C    . PHE A 1 20  ? 107.551 106.533 132.441 1.00 32.87  ? 20  PHE U C    1 
ATOM   53   O O    . PHE A 1 20  ? 107.529 106.954 131.275 1.00 36.54  ? 20  PHE U O    1 
ATOM   54   C CB   . PHE A 1 20  ? 109.651 106.220 133.800 1.00 21.11  ? 20  PHE U CB   1 
ATOM   55   C CG   . PHE A 1 20  ? 110.743 106.230 132.770 1.00 27.72  ? 20  PHE U CG   1 
ATOM   56   C CD1  . PHE A 1 20  ? 111.245 107.424 132.282 1.00 32.30  ? 20  PHE U CD1  1 
ATOM   57   C CD2  . PHE A 1 20  ? 111.275 105.042 132.298 1.00 28.11  ? 20  PHE U CD2  1 
ATOM   58   C CE1  . PHE A 1 20  ? 112.252 107.432 131.340 1.00 32.73  ? 20  PHE U CE1  1 
ATOM   59   C CE2  . PHE A 1 20  ? 112.283 105.046 131.354 1.00 25.27  ? 20  PHE U CE2  1 
ATOM   60   C CZ   . PHE A 1 20  ? 112.769 106.243 130.875 1.00 24.88  ? 20  PHE U CZ   1 
ATOM   61   N N    . LEU A 1 21  ? 106.758 105.538 132.857 1.00 33.51  ? 21  LEU U N    1 
ATOM   62   C CA   . LEU A 1 21  ? 105.835 104.878 131.936 1.00 28.60  ? 21  LEU U CA   1 
ATOM   63   C C    . LEU A 1 21  ? 104.769 105.839 131.421 1.00 31.54  ? 21  LEU U C    1 
ATOM   64   O O    . LEU A 1 21  ? 104.445 105.838 130.226 1.00 39.00  ? 21  LEU U O    1 
ATOM   65   C CB   . LEU A 1 21  ? 105.192 103.678 132.630 1.00 29.28  ? 21  LEU U CB   1 
ATOM   66   C CG   . LEU A 1 21  ? 104.313 102.759 131.777 1.00 30.43  ? 21  LEU U CG   1 
ATOM   67   C CD1  . LEU A 1 21  ? 105.155 101.980 130.778 1.00 32.98  ? 21  LEU U CD1  1 
ATOM   68   C CD2  . LEU A 1 21  ? 103.520 101.816 132.664 1.00 27.51  ? 21  LEU U CD2  1 
ATOM   69   N N    . LEU A 1 22  ? 104.212 106.665 132.312 1.00 29.19  ? 22  LEU U N    1 
ATOM   70   C CA   . LEU A 1 22  ? 103.189 107.619 131.899 1.00 30.59  ? 22  LEU U CA   1 
ATOM   71   C C    . LEU A 1 22  ? 103.744 108.620 130.896 1.00 34.37  ? 22  LEU U C    1 
ATOM   72   O O    . LEU A 1 22  ? 103.088 108.932 129.893 1.00 39.94  ? 22  LEU U O    1 
ATOM   73   C CB   . LEU A 1 22  ? 102.623 108.346 133.117 1.00 29.61  ? 22  LEU U CB   1 
ATOM   74   C CG   . LEU A 1 22  ? 101.481 109.324 132.828 1.00 33.54  ? 22  LEU U CG   1 
ATOM   75   C CD1  . LEU A 1 22  ? 100.234 108.582 132.372 1.00 30.66  ? 22  LEU U CD1  1 
ATOM   76   C CD2  . LEU A 1 22  ? 101.187 110.192 134.037 1.00 32.29  ? 22  LEU U CD2  1 
ATOM   77   N N    . LEU A 1 23  ? 104.951 109.134 131.149 1.00 23.98  ? 23  LEU U N    1 
ATOM   78   C CA   . LEU A 1 23  ? 105.550 110.079 130.216 1.00 19.61  ? 23  LEU U CA   1 
ATOM   79   C C    . LEU A 1 23  ? 105.802 109.428 128.862 1.00 29.54  ? 23  LEU U C    1 
ATOM   80   O O    . LEU A 1 23  ? 105.559 110.043 127.818 1.00 34.17  ? 23  LEU U O    1 
ATOM   81   C CB   . LEU A 1 23  ? 106.846 110.641 130.800 1.00 20.47  ? 23  LEU U CB   1 
ATOM   82   C CG   . LEU A 1 23  ? 107.545 111.751 130.013 1.00 25.91  ? 23  LEU U CG   1 
ATOM   83   C CD1  . LEU A 1 23  ? 106.579 112.887 129.709 1.00 26.48  ? 23  LEU U CD1  1 
ATOM   84   C CD2  . LEU A 1 23  ? 108.756 112.269 130.766 1.00 23.99  ? 23  LEU U CD2  1 
ATOM   85   N N    . ALA A 1 24  ? 106.278 108.180 128.857 1.00 30.70  ? 24  ALA U N    1 
ATOM   86   C CA   . ALA A 1 24  ? 106.510 107.493 127.589 1.00 22.62  ? 24  ALA U CA   1 
ATOM   87   C C    . ALA A 1 24  ? 105.211 107.330 126.804 1.00 32.25  ? 24  ALA U C    1 
ATOM   88   O O    . ALA A 1 24  ? 105.165 107.591 125.593 1.00 37.20  ? 24  ALA U O    1 
ATOM   89   C CB   . ALA A 1 24  ? 107.164 106.135 127.844 1.00 21.25  ? 24  ALA U CB   1 
ATOM   90   N N    . ALA A 1 25  ? 104.140 106.906 127.481 1.00 26.31  ? 25  ALA U N    1 
ATOM   91   C CA   . ALA A 1 25  ? 102.856 106.729 126.801 1.00 23.99  ? 25  ALA U CA   1 
ATOM   92   C C    . ALA A 1 25  ? 102.324 108.053 126.260 1.00 28.09  ? 25  ALA U C    1 
ATOM   93   O O    . ALA A 1 25  ? 101.813 108.116 125.130 1.00 32.90  ? 25  ALA U O    1 
ATOM   94   C CB   . ALA A 1 25  ? 101.845 106.090 127.751 1.00 21.78  ? 25  ALA U CB   1 
ATOM   95   N N    . LEU A 1 26  ? 102.435 109.126 127.052 1.00 29.17  ? 26  LEU U N    1 
ATOM   96   C CA   . LEU A 1 26  ? 101.962 110.427 126.598 1.00 23.92  ? 26  LEU U CA   1 
ATOM   97   C C    . LEU A 1 26  ? 102.742 110.902 125.380 1.00 24.26  ? 26  LEU U C    1 
ATOM   98   O O    . LEU A 1 26  ? 102.160 111.450 124.438 1.00 30.98  ? 26  LEU U O    1 
ATOM   99   C CB   . LEU A 1 26  ? 102.051 111.454 127.725 1.00 27.11  ? 26  LEU U CB   1 
ATOM   100  C CG   . LEU A 1 26  ? 101.114 111.262 128.921 1.00 22.14  ? 26  LEU U CG   1 
ATOM   101  C CD1  . LEU A 1 26  ? 101.315 112.369 129.939 1.00 24.28  ? 26  LEU U CD1  1 
ATOM   102  C CD2  . LEU A 1 26  ? 99.669  111.209 128.463 1.00 22.97  ? 26  LEU U CD2  1 
ATOM   103  N N    . ILE A 1 27  ? 104.061 110.698 125.380 1.00 20.22  ? 27  ILE U N    1 
ATOM   104  C CA   . ILE A 1 27  ? 104.867 111.108 124.234 1.00 22.32  ? 27  ILE U CA   1 
ATOM   105  C C    . ILE A 1 27  ? 104.490 110.303 122.995 1.00 23.54  ? 27  ILE U C    1 
ATOM   106  O O    . ILE A 1 27  ? 104.450 110.837 121.882 1.00 26.84  ? 27  ILE U O    1 
ATOM   107  C CB   . ILE A 1 27  ? 106.367 110.996 124.559 1.00 25.96  ? 27  ILE U CB   1 
ATOM   108  C CG1  . ILE A 1 27  ? 106.742 111.992 125.658 1.00 20.46  ? 27  ILE U CG1  1 
ATOM   109  C CG2  . ILE A 1 27  ? 107.207 111.262 123.320 1.00 25.61  ? 27  ILE U CG2  1 
ATOM   110  C CD1  . ILE A 1 27  ? 108.192 111.922 126.082 1.00 15.42  ? 27  ILE U CD1  1 
ATOM   111  N N    . VAL A 1 28  ? 104.208 109.008 123.164 1.00 26.91  ? 28  VAL U N    1 
ATOM   112  C CA   . VAL A 1 28  ? 103.813 108.186 122.018 1.00 25.99  ? 28  VAL U CA   1 
ATOM   113  C C    . VAL A 1 28  ? 102.503 108.696 121.417 1.00 25.12  ? 28  VAL U C    1 
ATOM   114  O O    . VAL A 1 28  ? 102.372 108.843 120.192 1.00 29.86  ? 28  VAL U O    1 
ATOM   115  C CB   . VAL A 1 28  ? 103.705 106.707 122.430 1.00 25.85  ? 28  VAL U CB   1 
ATOM   116  C CG1  . VAL A 1 28  ? 103.015 105.894 121.348 1.00 23.70  ? 28  VAL U CG1  1 
ATOM   117  C CG2  . VAL A 1 28  ? 105.084 106.136 122.717 1.00 26.03  ? 28  VAL U CG2  1 
ATOM   118  N N    . LEU A 1 29  ? 101.514 108.975 122.272 1.00 21.20  ? 29  LEU U N    1 
ATOM   119  C CA   . LEU A 1 29  ? 100.244 109.503 121.771 1.00 24.21  ? 29  LEU U CA   1 
ATOM   120  C C    . LEU A 1 29  ? 100.435 110.863 121.102 1.00 29.63  ? 29  LEU U C    1 
ATOM   121  O O    . LEU A 1 29  ? 99.820  111.150 120.062 1.00 33.14  ? 29  LEU U O    1 
ATOM   122  C CB   . LEU A 1 29  ? 99.229  109.602 122.910 1.00 24.15  ? 29  LEU U CB   1 
ATOM   123  C CG   . LEU A 1 29  ? 98.723  108.281 123.492 1.00 26.48  ? 29  LEU U CG   1 
ATOM   124  C CD1  . LEU A 1 29  ? 97.661  108.535 124.544 1.00 22.50  ? 29  LEU U CD1  1 
ATOM   125  C CD2  . LEU A 1 29  ? 98.182  107.383 122.395 1.00 25.49  ? 29  LEU U CD2  1 
ATOM   126  N N    . TYR A 1 30  ? 101.285 111.709 121.689 1.00 23.79  ? 30  TYR U N    1 
ATOM   127  C CA   . TYR A 1 30  ? 101.596 113.011 121.108 1.00 18.29  ? 30  TYR U CA   1 
ATOM   128  C C    . TYR A 1 30  ? 102.175 112.860 119.710 1.00 22.71  ? 30  TYR U C    1 
ATOM   129  O O    . TYR A 1 30  ? 101.780 113.569 118.778 1.00 25.94  ? 30  TYR U O    1 
ATOM   130  C CB   . TYR A 1 30  ? 102.565 113.761 122.026 1.00 16.48  ? 30  TYR U CB   1 
ATOM   131  C CG   . TYR A 1 30  ? 102.701 115.241 121.749 1.00 24.49  ? 30  TYR U CG   1 
ATOM   132  C CD1  . TYR A 1 30  ? 101.646 116.113 121.986 1.00 18.12  ? 30  TYR U CD1  1 
ATOM   133  C CD2  . TYR A 1 30  ? 103.893 115.771 121.275 1.00 18.31  ? 30  TYR U CD2  1 
ATOM   134  C CE1  . TYR A 1 30  ? 101.774 117.468 121.745 1.00 14.14  ? 30  TYR U CE1  1 
ATOM   135  C CE2  . TYR A 1 30  ? 104.028 117.123 121.030 1.00 19.90  ? 30  TYR U CE2  1 
ATOM   136  C CZ   . TYR A 1 30  ? 102.966 117.967 121.266 1.00 17.66  ? 30  TYR U CZ   1 
ATOM   137  O OH   . TYR A 1 30  ? 103.099 119.314 121.022 1.00 26.50  ? 30  TYR U OH   1 
ATOM   138  N N    . LEU A 1 31  ? 103.115 111.926 119.548 1.00 16.39  ? 31  LEU U N    1 
ATOM   139  C CA   . LEU A 1 31  ? 103.735 111.706 118.247 1.00 17.55  ? 31  LEU U CA   1 
ATOM   140  C C    . LEU A 1 31  ? 102.713 111.233 117.221 1.00 19.44  ? 31  LEU U C    1 
ATOM   141  O O    . LEU A 1 31  ? 102.712 111.703 116.076 1.00 25.50  ? 31  LEU U O    1 
ATOM   142  C CB   . LEU A 1 31  ? 104.872 110.690 118.370 1.00 15.56  ? 31  LEU U CB   1 
ATOM   143  C CG   . LEU A 1 31  ? 106.138 111.139 119.097 1.00 18.48  ? 31  LEU U CG   1 
ATOM   144  C CD1  . LEU A 1 31  ? 107.167 110.020 119.118 1.00 19.73  ? 31  LEU U CD1  1 
ATOM   145  C CD2  . LEU A 1 31  ? 106.719 112.388 118.458 1.00 18.02  ? 31  LEU U CD2  1 
ATOM   146  N N    . LEU A 1 32  ? 101.840 110.299 117.610 1.00 15.48  ? 32  LEU U N    1 
ATOM   147  C CA   . LEU A 1 32  ? 100.835 109.806 116.666 1.00 18.65  ? 32  LEU U CA   1 
ATOM   148  C C    . LEU A 1 32  ? 99.904  110.928 116.207 1.00 23.67  ? 32  LEU U C    1 
ATOM   149  O O    . LEU A 1 32  ? 99.653  111.099 115.002 1.00 25.59  ? 32  LEU U O    1 
ATOM   150  C CB   . LEU A 1 32  ? 100.036 108.664 117.296 1.00 19.60  ? 32  LEU U CB   1 
ATOM   151  C CG   . LEU A 1 32  ? 100.769 107.346 117.553 1.00 18.68  ? 32  LEU U CG   1 
ATOM   152  C CD1  . LEU A 1 32  ? 99.847  106.343 118.223 1.00 21.50  ? 32  LEU U CD1  1 
ATOM   153  C CD2  . LEU A 1 32  ? 101.326 106.773 116.262 1.00 19.75  ? 32  LEU U CD2  1 
ATOM   154  N N    . GLY A 1 33  ? 99.393  111.715 117.159 1.00 23.93  ? 33  GLY U N    1 
ATOM   155  C CA   . GLY A 1 33  ? 98.503  112.808 116.787 1.00 19.21  ? 33  GLY U CA   1 
ATOM   156  C C    . GLY A 1 33  ? 99.187  113.854 115.929 1.00 25.72  ? 33  GLY U C    1 
ATOM   157  O O    . GLY A 1 33  ? 98.614  114.346 114.949 1.00 28.82  ? 33  GLY U O    1 
ATOM   158  N N    . GLY A 1 34  ? 100.432 114.198 116.272 1.00 21.95  ? 34  GLY U N    1 
ATOM   159  C CA   . GLY A 1 34  ? 101.163 115.171 115.486 1.00 19.04  ? 34  GLY U CA   1 
ATOM   160  C C    . GLY A 1 34  ? 101.418 114.699 114.072 1.00 22.99  ? 34  GLY U C    1 
ATOM   161  O O    . GLY A 1 34  ? 101.321 115.481 113.120 1.00 28.58  ? 34  GLY U O    1 
ATOM   162  N N    . ALA A 1 35  ? 101.762 113.419 113.908 1.00 18.55  ? 35  ALA U N    1 
ATOM   163  C CA   . ALA A 1 35  ? 101.938 112.879 112.565 1.00 17.78  ? 35  ALA U CA   1 
ATOM   164  C C    . ALA A 1 35  ? 100.650 112.966 111.755 1.00 20.26  ? 35  ALA U C    1 
ATOM   165  O O    . ALA A 1 35  ? 100.674 113.375 110.585 1.00 21.41  ? 35  ALA U O    1 
ATOM   166  C CB   . ALA A 1 35  ? 102.421 111.432 112.645 1.00 15.61  ? 35  ALA U CB   1 
ATOM   167  N N    . ALA A 1 36  ? 99.516  112.599 112.361 1.00 24.22  ? 36  ALA U N    1 
ATOM   168  C CA   . ALA A 1 36  ? 98.254  112.663 111.622 1.00 19.42  ? 36  ALA U CA   1 
ATOM   169  C C    . ALA A 1 36  ? 97.935  114.091 111.188 1.00 25.75  ? 36  ALA U C    1 
ATOM   170  O O    . ALA A 1 36  ? 97.566  114.332 110.023 1.00 28.08  ? 36  ALA U O    1 
ATOM   171  C CB   . ALA A 1 36  ? 97.118  112.092 112.472 1.00 22.29  ? 36  ALA U CB   1 
ATOM   172  N N    . VAL A 1 37  ? 98.198  115.064 112.065 1.00 29.56  ? 37  VAL U N    1 
ATOM   173  C CA   . VAL A 1 37  ? 97.889  116.448 111.727 1.00 25.58  ? 37  VAL U CA   1 
ATOM   174  C C    . VAL A 1 37  ? 98.826  116.955 110.640 1.00 24.97  ? 37  VAL U C    1 
ATOM   175  O O    . VAL A 1 37  ? 98.388  117.610 109.684 1.00 29.03  ? 37  VAL U O    1 
ATOM   176  C CB   . VAL A 1 37  ? 97.943  117.336 112.983 1.00 24.01  ? 37  VAL U CB   1 
ATOM   177  C CG1  . VAL A 1 37  ? 97.774  118.797 112.609 1.00 26.26  ? 37  VAL U CG1  1 
ATOM   178  C CG2  . VAL A 1 37  ? 96.872  116.911 113.973 1.00 23.89  ? 37  VAL U CG2  1 
ATOM   179  N N    . PHE A 1 38  ? 100.126 116.673 110.761 1.00 26.03  ? 38  PHE U N    1 
ATOM   180  C CA   . PHE A 1 38  ? 101.071 117.212 109.791 1.00 20.23  ? 38  PHE U CA   1 
ATOM   181  C C    . PHE A 1 38  ? 100.809 116.619 108.412 1.00 25.81  ? 38  PHE U C    1 
ATOM   182  O O    . PHE A 1 38  ? 100.882 117.328 107.398 1.00 27.73  ? 38  PHE U O    1 
ATOM   183  C CB   . PHE A 1 38  ? 102.506 116.932 110.238 1.00 13.33  ? 38  PHE U CB   1 
ATOM   184  C CG   . PHE A 1 38  ? 103.119 118.036 111.049 1.00 21.63  ? 38  PHE U CG   1 
ATOM   185  C CD1  . PHE A 1 38  ? 103.404 119.264 110.473 1.00 21.49  ? 38  PHE U CD1  1 
ATOM   186  C CD2  . PHE A 1 38  ? 103.421 117.844 112.386 1.00 24.34  ? 38  PHE U CD2  1 
ATOM   187  C CE1  . PHE A 1 38  ? 103.969 120.280 111.220 1.00 22.92  ? 38  PHE U CE1  1 
ATOM   188  C CE2  . PHE A 1 38  ? 103.987 118.856 113.138 1.00 17.80  ? 38  PHE U CE2  1 
ATOM   189  C CZ   . PHE A 1 38  ? 104.262 120.073 112.553 1.00 19.75  ? 38  PHE U CZ   1 
ATOM   190  N N    . SER A 1 39  ? 100.519 115.313 108.356 1.00 24.94  ? 39  SER U N    1 
ATOM   191  C CA   . SER A 1 39  ? 100.229 114.684 107.073 1.00 24.27  ? 39  SER U CA   1 
ATOM   192  C C    . SER A 1 39  ? 99.003  115.312 106.429 1.00 28.42  ? 39  SER U C    1 
ATOM   193  O O    . SER A 1 39  ? 99.014  115.636 105.231 1.00 35.29  ? 39  SER U O    1 
ATOM   194  C CB   . SER A 1 39  ? 100.038 113.179 107.250 1.00 25.94  ? 39  SER U CB   1 
ATOM   195  O OG   . SER A 1 39  ? 98.759  112.882 107.779 1.00 34.73  ? 39  SER U OG   1 
ATOM   196  N N    . ALA A 1 40  ? 97.944  115.528 107.220 1.00 29.29  ? 40  ALA U N    1 
ATOM   197  C CA   . ALA A 1 40  ? 96.746  116.157 106.672 1.00 26.51  ? 40  ALA U CA   1 
ATOM   198  C C    . ALA A 1 40  ? 97.017  117.585 106.213 1.00 26.22  ? 40  ALA U C    1 
ATOM   199  O O    . ALA A 1 40  ? 96.384  118.064 105.266 1.00 31.74  ? 40  ALA U O    1 
ATOM   200  C CB   . ALA A 1 40  ? 95.620  116.138 107.706 1.00 25.88  ? 40  ALA U CB   1 
ATOM   201  N N    . LEU A 1 41  ? 97.948  118.275 106.872 1.00 28.45  ? 41  LEU U N    1 
ATOM   202  C CA   . LEU A 1 41  ? 98.269  119.645 106.479 1.00 21.31  ? 41  LEU U CA   1 
ATOM   203  C C    . LEU A 1 41  ? 99.102  119.711 105.200 1.00 28.69  ? 41  LEU U C    1 
ATOM   204  O O    . LEU A 1 41  ? 98.980  120.677 104.441 1.00 31.40  ? 41  LEU U O    1 
ATOM   205  C CB   . LEU A 1 41  ? 99.004  120.356 107.615 1.00 22.20  ? 41  LEU U CB   1 
ATOM   206  C CG   . LEU A 1 41  ? 98.146  120.931 108.743 1.00 23.22  ? 41  LEU U CG   1 
ATOM   207  C CD1  . LEU A 1 41  ? 99.026  121.541 109.822 1.00 22.26  ? 41  LEU U CD1  1 
ATOM   208  C CD2  . LEU A 1 41  ? 97.159  121.958 108.211 1.00 21.74  ? 41  LEU U CD2  1 
ATOM   209  N N    . GLU A 1 42  ? 99.952  118.711 104.938 1.00 35.69  ? 42  GLU U N    1 
ATOM   210  C CA   . GLU A 1 42  ? 100.992 118.870 103.922 1.00 27.14  ? 42  GLU U CA   1 
ATOM   211  C C    . GLU A 1 42  ? 100.874 117.970 102.691 1.00 31.09  ? 42  GLU U C    1 
ATOM   212  O O    . GLU A 1 42  ? 101.575 118.234 101.697 1.00 38.35  ? 42  GLU U O    1 
ATOM   213  C CB   . GLU A 1 42  ? 102.372 118.655 104.559 1.00 30.11  ? 42  GLU U CB   1 
ATOM   214  C CG   . GLU A 1 42  ? 102.680 119.605 105.701 1.00 24.31  ? 42  GLU U CG   1 
ATOM   215  C CD   . GLU A 1 42  ? 103.260 120.923 105.223 1.00 34.71  ? 42  GLU U CD   1 
ATOM   216  O OE1  . GLU A 1 42  ? 103.812 120.960 104.102 1.00 44.20  ? 42  GLU U OE1  1 
ATOM   217  O OE2  . GLU A 1 42  ? 103.166 121.923 105.965 1.00 40.12  ? 42  GLU U OE2  1 
ATOM   218  N N    . LEU A 1 43  ? 100.041 116.924 102.716 1.00 30.46  ? 43  LEU U N    1 
ATOM   219  C CA   . LEU A 1 43  ? 100.079 115.944 101.632 1.00 31.98  ? 43  LEU U CA   1 
ATOM   220  C C    . LEU A 1 43  ? 99.692  116.550 100.282 1.00 37.33  ? 43  LEU U C    1 
ATOM   221  O O    . LEU A 1 43  ? 100.325 116.254 99.256  1.00 42.57  ? 43  LEU U O    1 
ATOM   222  C CB   . LEU A 1 43  ? 99.159  114.767 101.961 1.00 36.61  ? 43  LEU U CB   1 
ATOM   223  C CG   . LEU A 1 43  ? 99.381  113.469 101.184 1.00 35.57  ? 43  LEU U CG   1 
ATOM   224  C CD1  . LEU A 1 43  ? 100.860 113.171 101.008 1.00 35.64  ? 43  LEU U CD1  1 
ATOM   225  C CD2  . LEU A 1 43  ? 98.680  112.308 101.868 1.00 35.43  ? 43  LEU U CD2  1 
ATOM   226  N N    . ALA A 1 44  ? 98.644  117.379 100.254 1.00 37.81  ? 44  ALA U N    1 
ATOM   227  C CA   . ALA A 1 44  ? 98.184  117.943 98.985  1.00 35.37  ? 44  ALA U CA   1 
ATOM   228  C C    . ALA A 1 44  ? 99.236  118.848 98.359  1.00 44.06  ? 44  ALA U C    1 
ATOM   229  O O    . ALA A 1 44  ? 99.477  118.791 97.146  1.00 50.82  ? 44  ALA U O    1 
ATOM   230  C CB   . ALA A 1 44  ? 96.874  118.705 99.193  1.00 39.18  ? 44  ALA U CB   1 
ATOM   231  N N    . HIS A 1 45  ? 99.874  119.692 99.173  1.00 42.55  ? 45  HIS U N    1 
ATOM   232  C CA   . HIS A 1 45  ? 100.942 120.548 98.671  1.00 40.82  ? 45  HIS U CA   1 
ATOM   233  C C    . HIS A 1 45  ? 102.096 119.719 98.129  1.00 46.14  ? 45  HIS U C    1 
ATOM   234  O O    . HIS A 1 45  ? 102.665 120.040 97.077  1.00 50.96  ? 45  HIS U O    1 
ATOM   235  C CB   . HIS A 1 45  ? 101.426 121.493 99.774  1.00 44.64  ? 45  HIS U CB   1 
ATOM   236  C CG   . HIS A 1 45  ? 102.378 122.541 99.293  1.00 50.34  ? 45  HIS U CG   1 
ATOM   237  N ND1  . HIS A 1 45  ? 101.963 123.679 98.636  1.00 51.39  ? 45  HIS U ND1  1 
ATOM   238  C CD2  . HIS A 1 45  ? 103.730 122.627 99.369  1.00 48.11  ? 45  HIS U CD2  1 
ATOM   239  C CE1  . HIS A 1 45  ? 103.014 124.420 98.331  1.00 47.67  ? 45  HIS U CE1  1 
ATOM   240  N NE2  . HIS A 1 45  ? 104.097 123.803 98.766  1.00 45.42  ? 45  HIS U NE2  1 
ATOM   241  N N    . GLU A 1 46  ? 102.458 118.643 98.835  1.00 43.55  ? 46  GLU U N    1 
ATOM   242  C CA   . GLU A 1 46  ? 103.553 117.794 98.373  1.00 39.64  ? 46  GLU U CA   1 
ATOM   243  C C    . GLU A 1 46  ? 103.233 117.188 97.011  1.00 38.22  ? 46  GLU U C    1 
ATOM   244  O O    . GLU A 1 46  ? 104.071 117.197 96.095  1.00 44.54  ? 46  GLU U O    1 
ATOM   245  C CB   . GLU A 1 46  ? 103.824 116.704 99.408  1.00 44.03  ? 46  GLU U CB   1 
ATOM   246  C CG   . GLU A 1 46  ? 105.192 116.060 99.320  1.00 46.51  ? 46  GLU U CG   1 
ATOM   247  C CD   . GLU A 1 46  ? 105.123 114.556 99.473  1.00 49.76  ? 46  GLU U CD   1 
ATOM   248  O OE1  . GLU A 1 46  ? 104.193 114.073 100.147 1.00 50.04  ? 46  GLU U OE1  1 
ATOM   249  O OE2  . GLU A 1 46  ? 106.004 113.854 98.935  1.00 49.20  ? 46  GLU U OE2  1 
ATOM   250  N N    . ARG A 1 47  ? 102.015 116.662 96.855  1.00 39.62  ? 47  ARG U N    1 
ATOM   251  C CA   . ARG A 1 47  ? 101.629 116.054 95.584  1.00 42.86  ? 47  ARG U CA   1 
ATOM   252  C C    . ARG A 1 47  ? 101.622 117.083 94.458  1.00 47.07  ? 47  ARG U C    1 
ATOM   253  O O    . ARG A 1 47  ? 102.074 116.800 93.340  1.00 51.96  ? 47  ARG U O    1 
ATOM   254  C CB   . ARG A 1 47  ? 100.262 115.383 95.707  1.00 44.75  ? 47  ARG U CB   1 
ATOM   255  C CG   . ARG A 1 47  ? 100.215 114.230 96.699  1.00 47.74  ? 47  ARG U CG   1 
ATOM   256  C CD   . ARG A 1 47  ? 100.004 112.900 95.984  1.00 50.82  ? 47  ARG U CD   1 
ATOM   257  N NE   . ARG A 1 47  ? 99.518  111.840 96.861  1.00 54.20  ? 47  ARG U NE   1 
ATOM   258  C CZ   . ARG A 1 47  ? 98.329  111.826 97.451  1.00 54.74  ? 47  ARG U CZ   1 
ATOM   259  N NH1  . ARG A 1 47  ? 97.452  112.799 97.267  1.00 51.45  ? 47  ARG U NH1  1 
ATOM   260  N NH2  . ARG A 1 47  ? 98.010  110.804 98.239  1.00 51.68  ? 47  ARG U NH2  1 
ATOM   261  N N    . GLN A 1 48  ? 101.101 118.284 94.731  1.00 48.63  ? 48  GLN U N    1 
ATOM   262  C CA   . GLN A 1 48  ? 101.068 119.320 93.703  1.00 48.10  ? 48  GLN U CA   1 
ATOM   263  C C    . GLN A 1 48  ? 102.476 119.717 93.274  1.00 49.22  ? 48  GLN U C    1 
ATOM   264  O O    . GLN A 1 48  ? 102.741 119.901 92.077  1.00 52.11  ? 48  GLN U O    1 
ATOM   265  C CB   . GLN A 1 48  ? 100.300 120.538 94.211  1.00 49.84  ? 48  GLN U CB   1 
ATOM   266  C CG   . GLN A 1 48  ? 99.506  121.268 93.142  1.00 52.81  ? 48  GLN U CG   1 
ATOM   267  C CD   . GLN A 1 48  ? 98.295  121.986 93.705  1.00 58.95  ? 48  GLN U CD   1 
ATOM   268  O OE1  . GLN A 1 48  ? 98.137  122.104 94.920  1.00 58.27  ? 48  GLN U OE1  1 
ATOM   269  N NE2  . GLN A 1 48  ? 97.434  122.475 92.820  1.00 56.91  ? 48  GLN U NE2  1 
ATOM   270  N N    . ALA A 1 49  ? 103.396 119.846 94.234  1.00 47.55  ? 49  ALA U N    1 
ATOM   271  C CA   . ALA A 1 49  ? 104.776 120.187 93.889  1.00 44.25  ? 49  ALA U CA   1 
ATOM   272  C C    . ALA A 1 49  ? 105.422 119.095 93.046  1.00 47.20  ? 49  ALA U C    1 
ATOM   273  O O    . ALA A 1 49  ? 106.147 119.388 92.083  1.00 48.07  ? 49  ALA U O    1 
ATOM   274  C CB   . ALA A 1 49  ? 105.584 120.437 95.160  1.00 43.75  ? 49  ALA U CB   1 
ATOM   275  N N    . LYS A 1 50  ? 105.175 117.825 93.387  1.00 47.15  ? 50  LYS U N    1 
ATOM   276  C CA   . LYS A 1 50  ? 105.733 116.736 92.588  1.00 42.90  ? 50  LYS U CA   1 
ATOM   277  C C    . LYS A 1 50  ? 105.203 116.767 91.161  1.00 44.41  ? 50  LYS U C    1 
ATOM   278  O O    . LYS A 1 50  ? 105.966 116.581 90.201  1.00 51.01  ? 50  LYS U O    1 
ATOM   279  C CB   . LYS A 1 50  ? 105.445 115.388 93.242  1.00 43.51  ? 50  LYS U CB   1 
ATOM   280  C CG   . LYS A 1 50  ? 106.369 115.053 94.398  1.00 43.69  ? 50  LYS U CG   1 
ATOM   281  C CD   . LYS A 1 50  ? 106.168 113.624 94.858  1.00 46.84  ? 50  LYS U CD   1 
ATOM   282  C CE   . LYS A 1 50  ? 107.042 113.290 96.052  1.00 47.21  ? 50  LYS U CE   1 
ATOM   283  N NZ   . LYS A 1 50  ? 108.053 114.346 96.327  1.00 46.36  ? 50  LYS U NZ   1 
ATOM   284  N N    . GLN A 1 51  ? 103.894 116.987 90.998  1.00 46.70  ? 51  GLN U N    1 
ATOM   285  C CA   . GLN A 1 51  ? 103.327 117.056 89.654  1.00 46.26  ? 51  GLN U CA   1 
ATOM   286  C C    . GLN A 1 51  ? 103.915 118.221 88.866  1.00 48.57  ? 51  GLN U C    1 
ATOM   287  O O    . GLN A 1 51  ? 104.201 118.094 87.666  1.00 52.46  ? 51  GLN U O    1 
ATOM   288  C CB   . GLN A 1 51  ? 101.805 117.166 89.733  1.00 48.71  ? 51  GLN U CB   1 
ATOM   289  C CG   . GLN A 1 51  ? 101.135 117.384 88.389  1.00 52.52  ? 51  GLN U CG   1 
ATOM   290  C CD   . GLN A 1 51  ? 99.653  117.651 88.516  1.00 56.98  ? 51  GLN U CD   1 
ATOM   291  O OE1  . GLN A 1 51  ? 99.113  117.722 89.618  1.00 57.60  ? 51  GLN U OE1  1 
ATOM   292  N NE2  . GLN A 1 51  ? 98.981  117.797 87.379  1.00 51.71  ? 51  GLN U NE2  1 
ATOM   293  N N    . ARG A 1 52  ? 104.106 119.368 89.526  1.00 50.07  ? 52  ARG U N    1 
ATOM   294  C CA   . ARG A 1 52  ? 104.694 120.521 88.853  1.00 48.15  ? 52  ARG U CA   1 
ATOM   295  C C    . ARG A 1 52  ? 106.109 120.220 88.377  1.00 49.05  ? 52  ARG U C    1 
ATOM   296  O O    . ARG A 1 52  ? 106.478 120.556 87.242  1.00 51.30  ? 52  ARG U O    1 
ATOM   297  C CB   . ARG A 1 52  ? 104.689 121.720 89.798  1.00 46.10  ? 52  ARG U CB   1 
ATOM   298  C CG   . ARG A 1 52  ? 105.279 122.990 89.220  1.00 45.65  ? 52  ARG U CG   1 
ATOM   299  C CD   . ARG A 1 52  ? 104.538 124.194 89.764  1.00 48.88  ? 52  ARG U CD   1 
ATOM   300  N NE   . ARG A 1 52  ? 104.704 124.298 91.210  1.00 53.75  ? 52  ARG U NE   1 
ATOM   301  C CZ   . ARG A 1 52  ? 103.705 124.421 92.073  1.00 53.83  ? 52  ARG U CZ   1 
ATOM   302  N NH1  . ARG A 1 52  ? 102.446 124.468 91.672  1.00 49.69  ? 52  ARG U NH1  1 
ATOM   303  N NH2  . ARG A 1 52  ? 103.976 124.491 93.372  1.00 50.93  ? 52  ARG U NH2  1 
ATOM   304  N N    . TRP A 1 53  ? 106.917 119.578 89.227  1.00 49.22  ? 53  TRP U N    1 
ATOM   305  C CA   . TRP A 1 53  ? 108.273 119.220 88.815  1.00 44.77  ? 53  TRP U CA   1 
ATOM   306  C C    . TRP A 1 53  ? 108.260 118.247 87.646  1.00 44.16  ? 53  TRP U C    1 
ATOM   307  O O    . TRP A 1 53  ? 109.074 118.367 86.720  1.00 48.79  ? 53  TRP U O    1 
ATOM   308  C CB   . TRP A 1 53  ? 109.063 118.625 89.976  1.00 44.94  ? 53  TRP U CB   1 
ATOM   309  C CG   . TRP A 1 53  ? 110.199 117.762 89.490  1.00 43.67  ? 53  TRP U CG   1 
ATOM   310  C CD1  . TRP A 1 53  ? 110.305 116.405 89.604  1.00 45.69  ? 53  TRP U CD1  1 
ATOM   311  C CD2  . TRP A 1 53  ? 111.354 118.193 88.756  1.00 44.32  ? 53  TRP U CD2  1 
ATOM   312  N NE1  . TRP A 1 53  ? 111.468 115.969 89.017  1.00 44.13  ? 53  TRP U NE1  1 
ATOM   313  C CE2  . TRP A 1 53  ? 112.128 117.045 88.486  1.00 43.61  ? 53  TRP U CE2  1 
ATOM   314  C CE3  . TRP A 1 53  ? 111.816 119.435 88.311  1.00 44.81  ? 53  TRP U CE3  1 
ATOM   315  C CZ2  . TRP A 1 53  ? 113.337 117.107 87.796  1.00 43.67  ? 53  TRP U CZ2  1 
ATOM   316  C CZ3  . TRP A 1 53  ? 113.016 119.493 87.626  1.00 43.82  ? 53  TRP U CZ3  1 
ATOM   317  C CH2  . TRP A 1 53  ? 113.762 118.337 87.375  1.00 40.37  ? 53  TRP U CH2  1 
ATOM   318  N N    . GLU A 1 54  ? 107.371 117.250 87.685  1.00 53.10  ? 54  GLU U N    1 
ATOM   319  C CA   . GLU A 1 54  ? 107.312 116.289 86.590  1.00 51.76  ? 54  GLU U CA   1 
ATOM   320  C C    . GLU A 1 54  ? 106.962 116.981 85.278  1.00 54.00  ? 54  GLU U C    1 
ATOM   321  O O    . GLU A 1 54  ? 107.564 116.698 84.232  1.00 54.94  ? 54  GLU U O    1 
ATOM   322  C CB   . GLU A 1 54  ? 106.302 115.188 86.908  1.00 52.29  ? 54  GLU U CB   1 
ATOM   323  C CG   . GLU A 1 54  ? 106.086 114.196 85.780  1.00 56.95  ? 54  GLU U CG   1 
ATOM   324  C CD   . GLU A 1 54  ? 107.265 113.263 85.589  1.00 63.52  ? 54  GLU U CD   1 
ATOM   325  O OE1  . GLU A 1 54  ? 108.088 113.137 86.520  1.00 63.07  ? 54  GLU U OE1  1 
ATOM   326  O OE2  . GLU A 1 54  ? 107.367 112.652 84.504  1.00 62.64  ? 54  GLU U OE2  1 
ATOM   327  N N    . GLU A 1 55  ? 106.000 117.907 85.318  1.00 60.04  ? 55  GLU U N    1 
ATOM   328  C CA   . GLU A 1 55  ? 105.637 118.639 84.110  1.00 57.96  ? 55  GLU U CA   1 
ATOM   329  C C    . GLU A 1 55  ? 106.801 119.481 83.598  1.00 59.18  ? 55  GLU U C    1 
ATOM   330  O O    . GLU A 1 55  ? 107.055 119.531 82.389  1.00 57.73  ? 55  GLU U O    1 
ATOM   331  C CB   . GLU A 1 55  ? 104.412 119.514 84.375  1.00 57.41  ? 55  GLU U CB   1 
ATOM   332  C CG   . GLU A 1 55  ? 104.038 120.425 83.217  1.00 62.32  ? 55  GLU U CG   1 
ATOM   333  C CD   . GLU A 1 55  ? 103.452 119.669 82.041  1.00 66.59  ? 55  GLU U CD   1 
ATOM   334  O OE1  . GLU A 1 55  ? 103.040 118.503 82.223  1.00 67.94  ? 55  GLU U OE1  1 
ATOM   335  O OE2  . GLU A 1 55  ? 103.406 120.238 80.932  1.00 65.29  ? 55  GLU U OE2  1 
ATOM   336  N N    . ARG A 1 56  ? 107.522 120.150 84.504  1.00 59.13  ? 56  ARG U N    1 
ATOM   337  C CA   . ARG A 1 56  ? 108.665 120.960 84.082  1.00 52.83  ? 56  ARG U CA   1 
ATOM   338  C C    . ARG A 1 56  ? 109.758 120.107 83.442  1.00 55.87  ? 56  ARG U C    1 
ATOM   339  O O    . ARG A 1 56  ? 110.334 120.489 82.414  1.00 56.88  ? 56  ARG U O    1 
ATOM   340  C CB   . ARG A 1 56  ? 109.220 121.741 85.274  1.00 49.27  ? 56  ARG U CB   1 
ATOM   341  C CG   . ARG A 1 56  ? 108.426 122.989 85.610  1.00 51.89  ? 56  ARG U CG   1 
ATOM   342  C CD   . ARG A 1 56  ? 108.880 123.603 86.916  1.00 53.42  ? 56  ARG U CD   1 
ATOM   343  N NE   . ARG A 1 56  ? 108.137 124.815 87.236  1.00 54.51  ? 56  ARG U NE   1 
ATOM   344  C CZ   . ARG A 1 56  ? 108.160 125.420 88.414  1.00 55.84  ? 56  ARG U CZ   1 
ATOM   345  N NH1  . ARG A 1 56  ? 108.875 124.946 89.420  1.00 54.50  ? 56  ARG U NH1  1 
ATOM   346  N NH2  . ARG A 1 56  ? 107.451 126.532 88.585  1.00 56.37  ? 56  ARG U NH2  1 
ATOM   347  N N    . LEU A 1 57  ? 110.060 118.950 84.039  1.00 55.00  ? 57  LEU U N    1 
ATOM   348  C CA   . LEU A 1 57  ? 111.067 118.062 83.460  1.00 52.31  ? 57  LEU U CA   1 
ATOM   349  C C    . LEU A 1 57  ? 110.646 117.570 82.081  1.00 56.24  ? 57  LEU U C    1 
ATOM   350  O O    . LEU A 1 57  ? 111.460 117.537 81.148  1.00 56.70  ? 57  LEU U O    1 
ATOM   351  C CB   . LEU A 1 57  ? 111.330 116.881 84.390  1.00 49.18  ? 57  LEU U CB   1 
ATOM   352  C CG   . LEU A 1 57  ? 112.457 115.941 83.947  1.00 51.00  ? 57  LEU U CG   1 
ATOM   353  C CD1  . LEU A 1 57  ? 113.818 116.486 84.334  1.00 54.74  ? 57  LEU U CD1  1 
ATOM   354  C CD2  . LEU A 1 57  ? 112.254 114.557 84.541  1.00 54.86  ? 57  LEU U CD2  1 
ATOM   355  N N    . ALA A 1 58  ? 109.377 117.183 81.933  1.00 63.53  ? 58  ALA U N    1 
ATOM   356  C CA   . ALA A 1 58  ? 108.902 116.720 80.633  1.00 63.07  ? 58  ALA U CA   1 
ATOM   357  C C    . ALA A 1 58  ? 108.985 117.826 79.592  1.00 64.02  ? 58  ALA U C    1 
ATOM   358  O O    . ALA A 1 58  ? 109.378 117.587 78.442  1.00 61.78  ? 58  ALA U O    1 
ATOM   359  C CB   . ALA A 1 58  ? 107.471 116.195 80.752  1.00 64.16  ? 58  ALA U CB   1 
ATOM   360  N N    . GLN A 1 59  ? 108.621 119.055 79.980  1.00 69.35  ? 59  GLN U N    1 
ATOM   361  C CA   . GLN A 1 59  ? 108.687 120.161 79.033  1.00 68.14  ? 59  GLN U CA   1 
ATOM   362  C C    . GLN A 1 59  ? 110.120 120.467 78.623  1.00 69.13  ? 59  GLN U C    1 
ATOM   363  O O    . GLN A 1 59  ? 110.379 120.731 77.448  1.00 69.42  ? 59  GLN U O    1 
ATOM   364  C CB   . GLN A 1 59  ? 108.027 121.403 79.633  1.00 69.06  ? 59  GLN U CB   1 
ATOM   365  C CG   . GLN A 1 59  ? 108.058 122.619 78.721  1.00 71.78  ? 59  GLN U CG   1 
ATOM   366  C CD   . GLN A 1 59  ? 107.417 122.356 77.373  1.00 75.31  ? 59  GLN U CD   1 
ATOM   367  O OE1  . GLN A 1 59  ? 106.416 121.644 77.273  1.00 72.53  ? 59  GLN U OE1  1 
ATOM   368  N NE2  . GLN A 1 59  ? 107.993 122.930 76.323  1.00 72.16  ? 59  GLN U NE2  1 
ATOM   369  N N    . PHE A 1 60  ? 111.075 120.410 79.561  1.00 67.72  ? 60  PHE U N    1 
ATOM   370  C CA   . PHE A 1 60  ? 112.464 120.643 79.164  1.00 65.65  ? 60  PHE U CA   1 
ATOM   371  C C    . PHE A 1 60  ? 112.937 119.553 78.211  1.00 64.44  ? 60  PHE U C    1 
ATOM   372  O O    . PHE A 1 60  ? 113.565 119.837 77.175  1.00 61.26  ? 60  PHE U O    1 
ATOM   373  C CB   . PHE A 1 60  ? 113.366 120.701 80.397  1.00 63.95  ? 60  PHE U CB   1 
ATOM   374  C CG   . PHE A 1 60  ? 114.779 121.111 80.093  1.00 63.08  ? 60  PHE U CG   1 
ATOM   375  C CD1  . PHE A 1 60  ? 115.108 122.448 79.934  1.00 62.12  ? 60  PHE U CD1  1 
ATOM   376  C CD2  . PHE A 1 60  ? 115.776 120.160 79.946  1.00 64.40  ? 60  PHE U CD2  1 
ATOM   377  C CE1  . PHE A 1 60  ? 116.405 122.827 79.655  1.00 58.76  ? 60  PHE U CE1  1 
ATOM   378  C CE2  . PHE A 1 60  ? 117.073 120.537 79.662  1.00 60.21  ? 60  PHE U CE2  1 
ATOM   379  C CZ   . PHE A 1 60  ? 117.389 121.870 79.515  1.00 56.89  ? 60  PHE U CZ   1 
ATOM   380  N N    . SER A 1 61  ? 112.624 118.294 78.546  1.00 72.84  ? 61  SER U N    1 
ATOM   381  C CA   . SER A 1 61  ? 113.070 117.168 77.733  1.00 71.15  ? 61  SER U CA   1 
ATOM   382  C C    . SER A 1 61  ? 112.575 117.327 76.307  1.00 72.53  ? 61  SER U C    1 
ATOM   383  O O    . SER A 1 61  ? 113.349 117.208 75.350  1.00 69.70  ? 61  SER U O    1 
ATOM   384  C CB   . SER A 1 61  ? 112.581 115.853 78.339  1.00 70.39  ? 61  SER U CB   1 
ATOM   385  O OG   . SER A 1 61  ? 113.036 114.744 77.582  1.00 72.26  ? 61  SER U OG   1 
ATOM   386  N N    . ARG A 1 62  ? 111.272 117.579 76.144  1.00 79.61  ? 62  ARG U N    1 
ATOM   387  C CA   . ARG A 1 62  ? 110.738 117.778 74.802  1.00 80.28  ? 62  ARG U CA   1 
ATOM   388  C C    . ARG A 1 62  ? 111.375 119.000 74.149  1.00 80.28  ? 62  ARG U C    1 
ATOM   389  O O    . ARG A 1 62  ? 111.714 118.972 72.959  1.00 81.36  ? 62  ARG U O    1 
ATOM   390  C CB   . ARG A 1 62  ? 109.218 117.922 74.865  1.00 82.81  ? 62  ARG U CB   1 
ATOM   391  C CG   . ARG A 1 62  ? 108.536 118.159 73.529  1.00 81.18  ? 62  ARG U CG   1 
ATOM   392  C CD   . ARG A 1 62  ? 107.072 118.499 73.747  1.00 81.38  ? 62  ARG U CD   1 
ATOM   393  N NE   . ARG A 1 62  ? 106.419 117.511 74.597  1.00 82.56  ? 62  ARG U NE   1 
ATOM   394  C CZ   . ARG A 1 62  ? 105.882 117.778 75.781  1.00 83.31  ? 62  ARG U CZ   1 
ATOM   395  N NH1  . ARG A 1 62  ? 105.937 118.992 76.305  1.00 82.94  ? 62  ARG U NH1  1 
ATOM   396  N NH2  . ARG A 1 62  ? 105.295 116.799 76.463  1.00 81.04  ? 62  ARG U NH2  1 
ATOM   397  N N    . GLY A 1 63  ? 111.514 120.091 74.913  1.00 77.12  ? 63  GLY U N    1 
ATOM   398  C CA   . GLY A 1 63  ? 112.079 121.321 74.380  1.00 77.19  ? 63  GLY U CA   1 
ATOM   399  C C    . GLY A 1 63  ? 113.397 121.118 73.663  1.00 77.92  ? 63  GLY U C    1 
ATOM   400  O O    . GLY A 1 63  ? 113.627 121.689 72.595  1.00 78.82  ? 63  GLY U O    1 
ATOM   401  N N    . HIS A 1 64  ? 114.283 120.303 74.238  1.00 74.96  ? 64  HIS U N    1 
ATOM   402  C CA   . HIS A 1 64  ? 115.615 120.138 73.657  1.00 75.74  ? 64  HIS U CA   1 
ATOM   403  C C    . HIS A 1 64  ? 115.963 118.699 73.296  1.00 74.36  ? 64  HIS U C    1 
ATOM   404  O O    . HIS A 1 64  ? 117.132 118.412 73.014  1.00 72.96  ? 64  HIS U O    1 
ATOM   405  C CB   . HIS A 1 64  ? 116.679 120.731 74.586  1.00 76.54  ? 64  HIS U CB   1 
ATOM   406  C CG   . HIS A 1 64  ? 116.335 122.094 75.101  1.00 76.27  ? 64  HIS U CG   1 
ATOM   407  N ND1  . HIS A 1 64  ? 116.180 122.368 76.443  1.00 75.00  ? 64  HIS U ND1  1 
ATOM   408  C CD2  . HIS A 1 64  ? 116.131 123.261 74.452  1.00 75.30  ? 64  HIS U CD2  1 
ATOM   409  C CE1  . HIS A 1 64  ? 115.887 123.649 76.593  1.00 72.86  ? 64  HIS U CE1  1 
ATOM   410  N NE2  . HIS A 1 64  ? 115.851 124.212 75.400  1.00 74.56  ? 64  HIS U NE2  1 
ATOM   411  N N    . GLN A 1 65  ? 114.984 117.793 73.283  1.00 79.27  ? 65  GLN U N    1 
ATOM   412  C CA   . GLN A 1 65  ? 115.155 116.413 72.822  1.00 80.32  ? 65  GLN U CA   1 
ATOM   413  C C    . GLN A 1 65  ? 116.266 115.652 73.541  1.00 78.41  ? 65  GLN U C    1 
ATOM   414  O O    . GLN A 1 65  ? 116.742 114.633 73.031  1.00 75.01  ? 65  GLN U O    1 
ATOM   415  C CB   . GLN A 1 65  ? 115.403 116.370 71.308  1.00 78.30  ? 65  GLN U CB   1 
ATOM   416  C CG   . GLN A 1 65  ? 114.364 117.102 70.477  1.00 78.74  ? 65  GLN U CG   1 
ATOM   417  C CD   . GLN A 1 65  ? 114.789 117.270 69.031  1.00 82.08  ? 65  GLN U CD   1 
ATOM   418  O OE1  . GLN A 1 65  ? 115.877 116.849 68.639  1.00 82.86  ? 65  GLN U OE1  1 
ATOM   419  N NE2  . GLN A 1 65  ? 113.927 117.886 68.229  1.00 80.86  ? 65  GLN U NE2  1 
ATOM   420  N N    . LEU A 1 66  ? 116.713 116.102 74.710  1.00 77.08  ? 66  LEU U N    1 
ATOM   421  C CA   . LEU A 1 66  ? 117.682 115.311 75.452  1.00 75.41  ? 66  LEU U CA   1 
ATOM   422  C C    . LEU A 1 66  ? 117.025 114.054 76.016  1.00 74.96  ? 66  LEU U C    1 
ATOM   423  O O    . LEU A 1 66  ? 115.851 114.050 76.387  1.00 73.64  ? 66  LEU U O    1 
ATOM   424  C CB   . LEU A 1 66  ? 118.300 116.122 76.590  1.00 72.28  ? 66  LEU U CB   1 
ATOM   425  C CG   . LEU A 1 66  ? 118.995 117.438 76.237  1.00 73.74  ? 66  LEU U CG   1 
ATOM   426  C CD1  . LEU A 1 66  ? 118.265 118.598 76.881  1.00 74.31  ? 66  LEU U CD1  1 
ATOM   427  C CD2  . LEU A 1 66  ? 120.448 117.409 76.667  1.00 74.77  ? 66  LEU U CD2  1 
ATOM   428  N N    . SER A 1 67  ? 117.804 112.978 76.069  1.00 77.06  ? 67  SER U N    1 
ATOM   429  C CA   . SER A 1 67  ? 117.321 111.722 76.618  1.00 74.07  ? 67  SER U CA   1 
ATOM   430  C C    . SER A 1 67  ? 117.118 111.831 78.129  1.00 77.21  ? 67  SER U C    1 
ATOM   431  O O    . SER A 1 67  ? 117.656 112.717 78.796  1.00 79.26  ? 67  SER U O    1 
ATOM   432  C CB   . SER A 1 67  ? 118.295 110.587 76.299  1.00 74.55  ? 67  SER U CB   1 
ATOM   433  O OG   . SER A 1 67  ? 117.884 109.375 76.904  1.00 76.45  ? 67  SER U OG   1 
ATOM   434  N N    . ARG A 1 68  ? 116.319 110.913 78.677  1.00 75.90  ? 68  ARG U N    1 
ATOM   435  C CA   . ARG A 1 68  ? 116.046 110.943 80.138  1.00 75.24  ? 68  ARG U CA   1 
ATOM   436  C C    . ARG A 1 68  ? 117.321 110.561 80.896  1.00 75.70  ? 68  ARG U C    1 
ATOM   437  O O    . ARG A 1 68  ? 117.610 111.214 81.916  1.00 76.76  ? 68  ARG U O    1 
ATOM   438  C CB   . ARG A 1 68  ? 114.890 110.002 80.488  1.00 75.09  ? 68  ARG U CB   1 
ATOM   439  C CG   . ARG A 1 68  ? 113.936 110.558 81.535  1.00 75.32  ? 68  ARG U CG   1 
ATOM   440  C CD   . ARG A 1 68  ? 113.347 111.899 81.139  1.00 74.22  ? 68  ARG U CD   1 
ATOM   441  N NE   . ARG A 1 68  ? 112.187 112.248 81.947  1.00 74.73  ? 68  ARG U NE   1 
ATOM   442  C CZ   . ARG A 1 68  ? 111.169 112.990 81.526  1.00 75.12  ? 68  ARG U CZ   1 
ATOM   443  N NH1  . ARG A 1 68  ? 110.076 113.094 82.261  1.00 73.75  ? 68  ARG U NH1  1 
ATOM   444  N NH2  . ARG A 1 68  ? 111.247 113.628 80.371  1.00 73.28  ? 68  ARG U NH2  1 
ATOM   445  N N    . ASP A 1 69  ? 118.062 109.561 80.407  1.00 74.59  ? 69  ASP U N    1 
ATOM   446  C CA   . ASP A 1 69  ? 119.238 109.094 81.135  1.00 74.99  ? 69  ASP U CA   1 
ATOM   447  C C    . ASP A 1 69  ? 120.314 110.170 81.195  1.00 76.42  ? 69  ASP U C    1 
ATOM   448  O O    . ASP A 1 69  ? 121.023 110.298 82.201  1.00 77.50  ? 69  ASP U O    1 
ATOM   449  C CB   . ASP A 1 69  ? 119.782 107.821 80.494  1.00 76.49  ? 69  ASP U CB   1 
ATOM   450  C CG   . ASP A 1 69  ? 118.788 106.677 80.530  1.00 79.52  ? 69  ASP U CG   1 
ATOM   451  O OD1  . ASP A 1 69  ? 117.950 106.650 81.456  1.00 79.26  ? 69  ASP U OD1  1 
ATOM   452  O OD2  . ASP A 1 69  ? 118.848 105.808 79.635  1.00 79.07  ? 69  ASP U OD2  1 
ATOM   453  N N    . GLU A 1 70  ? 120.468 110.936 80.112  1.00 69.06  ? 70  GLU U N    1 
ATOM   454  C CA   . GLU A 1 70  ? 121.461 112.004 80.105  1.00 67.97  ? 70  GLU U CA   1 
ATOM   455  C C    . GLU A 1 70  ? 121.123 113.053 81.154  1.00 69.75  ? 70  GLU U C    1 
ATOM   456  O O    . GLU A 1 70  ? 122.007 113.541 81.872  1.00 70.77  ? 70  GLU U O    1 
ATOM   457  C CB   . GLU A 1 70  ? 121.541 112.636 78.718  1.00 67.71  ? 70  GLU U CB   1 
ATOM   458  C CG   . GLU A 1 70  ? 121.701 111.631 77.590  1.00 69.99  ? 70  GLU U CG   1 
ATOM   459  C CD   . GLU A 1 70  ? 121.748 112.288 76.227  1.00 72.77  ? 70  GLU U CD   1 
ATOM   460  O OE1  . GLU A 1 70  ? 121.817 113.534 76.170  1.00 75.93  ? 70  GLU U OE1  1 
ATOM   461  O OE2  . GLU A 1 70  ? 121.719 111.557 75.212  1.00 72.13  ? 70  GLU U OE2  1 
ATOM   462  N N    . LEU A 1 71  ? 119.841 113.404 81.261  1.00 62.11  ? 71  LEU U N    1 
ATOM   463  C CA   . LEU A 1 71  ? 119.416 114.353 82.281  1.00 60.15  ? 71  LEU U CA   1 
ATOM   464  C C    . LEU A 1 71  ? 119.624 113.782 83.677  1.00 58.14  ? 71  LEU U C    1 
ATOM   465  O O    . LEU A 1 71  ? 120.000 114.515 84.601  1.00 60.17  ? 71  LEU U O    1 
ATOM   466  C CB   . LEU A 1 71  ? 117.950 114.732 82.063  1.00 60.83  ? 71  LEU U CB   1 
ATOM   467  C CG   . LEU A 1 71  ? 117.681 115.778 80.980  1.00 61.86  ? 71  LEU U CG   1 
ATOM   468  C CD1  . LEU A 1 71  ? 116.275 116.336 81.110  1.00 62.08  ? 71  LEU U CD1  1 
ATOM   469  C CD2  . LEU A 1 71  ? 118.709 116.898 81.037  1.00 60.31  ? 71  LEU U CD2  1 
ATOM   470  N N    . ARG A 1 72  ? 119.393 112.478 83.854  1.00 57.74  ? 72  ARG U N    1 
ATOM   471  C CA   . ARG A 1 72  ? 119.647 111.869 85.159  1.00 59.25  ? 72  ARG U CA   1 
ATOM   472  C C    . ARG A 1 72  ? 121.125 111.943 85.531  1.00 61.35  ? 72  ARG U C    1 
ATOM   473  O O    . ARG A 1 72  ? 121.467 112.247 86.681  1.00 61.25  ? 72  ARG U O    1 
ATOM   474  C CB   . ARG A 1 72  ? 119.175 110.413 85.150  1.00 60.74  ? 72  ARG U CB   1 
ATOM   475  C CG   . ARG A 1 72  ? 117.684 110.240 84.934  1.00 65.34  ? 72  ARG U CG   1 
ATOM   476  C CD   . ARG A 1 72  ? 116.908 110.399 86.232  1.00 66.14  ? 72  ARG U CD   1 
ATOM   477  N NE   . ARG A 1 72  ? 117.327 109.424 87.230  1.00 67.11  ? 72  ARG U NE   1 
ATOM   478  C CZ   . ARG A 1 72  ? 116.956 108.151 87.232  1.00 66.25  ? 72  ARG U CZ   1 
ATOM   479  N NH1  . ARG A 1 72  ? 116.149 107.664 86.303  1.00 63.31  ? 72  ARG U NH1  1 
ATOM   480  N NH2  . ARG A 1 72  ? 117.408 107.345 88.187  1.00 65.91  ? 72  ARG U NH2  1 
ATOM   481  N N    . GLY A 1 73  ? 122.012 111.670 84.573  1.00 56.03  ? 73  GLY U N    1 
ATOM   482  C CA   . GLY A 1 73  ? 123.440 111.797 84.839  1.00 53.06  ? 73  GLY U CA   1 
ATOM   483  C C    . GLY A 1 73  ? 123.860 113.219 85.157  1.00 53.27  ? 73  GLY U C    1 
ATOM   484  O O    . GLY A 1 73  ? 124.646 113.459 86.083  1.00 53.76  ? 73  GLY U O    1 
ATOM   485  N N    . PHE A 1 74  ? 123.333 114.182 84.397  1.00 46.72  ? 74  PHE U N    1 
ATOM   486  C CA   . PHE A 1 74  ? 123.627 115.589 84.656  1.00 40.95  ? 74  PHE U CA   1 
ATOM   487  C C    . PHE A 1 74  ? 123.155 115.995 86.048  1.00 44.45  ? 74  PHE U C    1 
ATOM   488  O O    . PHE A 1 74  ? 123.865 116.702 86.770  1.00 41.61  ? 74  PHE U O    1 
ATOM   489  C CB   . PHE A 1 74  ? 122.982 116.458 83.576  1.00 38.51  ? 74  PHE U CB   1 
ATOM   490  C CG   . PHE A 1 74  ? 123.368 117.906 83.644  1.00 42.11  ? 74  PHE U CG   1 
ATOM   491  C CD1  . PHE A 1 74  ? 124.678 118.298 83.422  1.00 41.08  ? 74  PHE U CD1  1 
ATOM   492  C CD2  . PHE A 1 74  ? 122.420 118.882 83.909  1.00 42.01  ? 74  PHE U CD2  1 
ATOM   493  C CE1  . PHE A 1 74  ? 125.039 119.627 83.479  1.00 40.75  ? 74  PHE U CE1  1 
ATOM   494  C CE2  . PHE A 1 74  ? 122.776 120.215 83.966  1.00 41.55  ? 74  PHE U CE2  1 
ATOM   495  C CZ   . PHE A 1 74  ? 124.087 120.589 83.749  1.00 40.93  ? 74  PHE U CZ   1 
ATOM   496  N N    . LEU A 1 75  ? 121.963 115.549 86.446  1.00 46.15  ? 75  LEU U N    1 
ATOM   497  C CA   . LEU A 1 75  ? 121.445 115.900 87.762  1.00 42.07  ? 75  LEU U CA   1 
ATOM   498  C C    . LEU A 1 75  ? 122.228 115.218 88.876  1.00 45.29  ? 75  LEU U C    1 
ATOM   499  O O    . LEU A 1 75  ? 122.388 115.794 89.956  1.00 44.33  ? 75  LEU U O    1 
ATOM   500  C CB   . LEU A 1 75  ? 119.962 115.545 87.857  1.00 40.91  ? 75  LEU U CB   1 
ATOM   501  C CG   . LEU A 1 75  ? 119.021 116.396 87.001  1.00 38.22  ? 75  LEU U CG   1 
ATOM   502  C CD1  . LEU A 1 75  ? 117.582 115.931 87.145  1.00 39.45  ? 75  LEU U CD1  1 
ATOM   503  C CD2  . LEU A 1 75  ? 119.152 117.867 87.353  1.00 39.50  ? 75  LEU U CD2  1 
ATOM   504  N N    . ARG A 1 76  ? 122.726 114.001 88.642  1.00 46.27  ? 76  ARG U N    1 
ATOM   505  C CA   . ARG A 1 76  ? 123.586 113.359 89.631  1.00 41.79  ? 76  ARG U CA   1 
ATOM   506  C C    . ARG A 1 76  ? 124.887 114.135 89.815  1.00 44.65  ? 76  ARG U C    1 
ATOM   507  O O    . ARG A 1 76  ? 125.345 114.345 90.946  1.00 42.04  ? 76  ARG U O    1 
ATOM   508  C CB   . ARG A 1 76  ? 123.873 111.920 89.210  1.00 40.80  ? 76  ARG U CB   1 
ATOM   509  C CG   . ARG A 1 76  ? 124.280 110.995 90.342  1.00 47.87  ? 76  ARG U CG   1 
ATOM   510  C CD   . ARG A 1 76  ? 124.689 109.629 89.809  1.00 48.26  ? 76  ARG U CD   1 
ATOM   511  N NE   . ARG A 1 76  ? 123.699 109.075 88.894  1.00 46.65  ? 76  ARG U NE   1 
ATOM   512  C CZ   . ARG A 1 76  ? 122.668 108.331 89.268  1.00 48.18  ? 76  ARG U CZ   1 
ATOM   513  N NH1  . ARG A 1 76  ? 122.452 108.033 90.539  1.00 45.12  ? 76  ARG U NH1  1 
ATOM   514  N NH2  . ARG A 1 76  ? 121.827 107.877 88.342  1.00 47.53  ? 76  ARG U NH2  1 
ATOM   515  N N    . HIS A 1 77  ? 125.488 114.580 88.706  1.00 44.46  ? 77  HIS U N    1 
ATOM   516  C CA   . HIS A 1 77  ? 126.675 115.425 88.799  1.00 36.51  ? 77  HIS U CA   1 
ATOM   517  C C    . HIS A 1 77  ? 126.372 116.726 89.536  1.00 39.51  ? 77  HIS U C    1 
ATOM   518  O O    . HIS A 1 77  ? 127.183 117.192 90.348  1.00 40.49  ? 77  HIS U O    1 
ATOM   519  C CB   . HIS A 1 77  ? 127.234 115.715 87.406  1.00 37.39  ? 77  HIS U CB   1 
ATOM   520  C CG   . HIS A 1 77  ? 128.019 114.581 86.829  1.00 41.03  ? 77  HIS U CG   1 
ATOM   521  N ND1  . HIS A 1 77  ? 128.583 114.628 85.572  1.00 41.29  ? 77  HIS U ND1  1 
ATOM   522  C CD2  . HIS A 1 77  ? 128.354 113.375 87.346  1.00 41.83  ? 77  HIS U CD2  1 
ATOM   523  C CE1  . HIS A 1 77  ? 129.217 113.496 85.333  1.00 39.98  ? 77  HIS U CE1  1 
ATOM   524  N NE2  . HIS A 1 77  ? 129.095 112.720 86.393  1.00 43.22  ? 77  HIS U NE2  1 
ATOM   525  N N    . TYR A 1 78  ? 125.213 117.327 89.265  1.00 43.16  ? 78  TYR U N    1 
ATOM   526  C CA   . TYR A 1 78  ? 124.857 118.575 89.934  1.00 36.94  ? 78  TYR U CA   1 
ATOM   527  C C    . TYR A 1 78  ? 124.647 118.355 91.427  1.00 37.29  ? 78  TYR U C    1 
ATOM   528  O O    . TYR A 1 78  ? 124.988 119.218 92.238  1.00 49.40  ? 78  TYR U O    1 
ATOM   529  C CB   . TYR A 1 78  ? 123.606 119.183 89.307  1.00 42.04  ? 78  TYR U CB   1 
ATOM   530  C CG   . TYR A 1 78  ? 123.249 120.526 89.901  1.00 41.41  ? 78  TYR U CG   1 
ATOM   531  C CD1  . TYR A 1 78  ? 124.157 121.579 89.868  1.00 39.46  ? 78  TYR U CD1  1 
ATOM   532  C CD2  . TYR A 1 78  ? 122.022 120.740 90.514  1.00 38.27  ? 78  TYR U CD2  1 
ATOM   533  C CE1  . TYR A 1 78  ? 123.845 122.807 90.414  1.00 35.55  ? 78  TYR U CE1  1 
ATOM   534  C CE2  . TYR A 1 78  ? 121.702 121.965 91.062  1.00 42.09  ? 78  TYR U CE2  1 
ATOM   535  C CZ   . TYR A 1 78  ? 122.618 122.996 91.009  1.00 41.59  ? 78  TYR U CZ   1 
ATOM   536  O OH   . TYR A 1 78  ? 122.307 124.219 91.552  1.00 45.65  ? 78  TYR U OH   1 
ATOM   537  N N    . GLU A 1 79  ? 124.064 117.216 91.807  1.00 38.18  ? 79  GLU U N    1 
ATOM   538  C CA   . GLU A 1 79  ? 123.915 116.894 93.222  1.00 41.00  ? 79  GLU U CA   1 
ATOM   539  C C    . GLU A 1 79  ? 125.273 116.745 93.893  1.00 45.92  ? 79  GLU U C    1 
ATOM   540  O O    . GLU A 1 79  ? 125.483 117.234 95.013  1.00 48.47  ? 79  GLU U O    1 
ATOM   541  C CB   . GLU A 1 79  ? 123.089 115.619 93.394  1.00 43.38  ? 79  GLU U CB   1 
ATOM   542  C CG   . GLU A 1 79  ? 121.595 115.854 93.481  1.00 48.93  ? 79  GLU U CG   1 
ATOM   543  C CD   . GLU A 1 79  ? 120.826 114.597 93.830  1.00 50.98  ? 79  GLU U CD   1 
ATOM   544  O OE1  . GLU A 1 79  ? 121.433 113.673 94.414  1.00 49.83  ? 79  GLU U OE1  1 
ATOM   545  O OE2  . GLU A 1 79  ? 119.616 114.534 93.535  1.00 52.54  ? 79  GLU U OE2  1 
ATOM   546  N N    . GLU A 1 80  ? 126.207 116.065 93.222  1.00 47.52  ? 80  GLU U N    1 
ATOM   547  C CA   . GLU A 1 80  ? 127.555 115.946 93.765  1.00 42.25  ? 80  GLU U CA   1 
ATOM   548  C C    . GLU A 1 80  ? 128.203 117.316 93.936  1.00 41.48  ? 80  GLU U C    1 
ATOM   549  O O    . GLU A 1 80  ? 128.864 117.579 94.948  1.00 40.33  ? 80  GLU U O    1 
ATOM   550  C CB   . GLU A 1 80  ? 128.405 115.058 92.860  1.00 42.26  ? 80  GLU U CB   1 
ATOM   551  C CG   . GLU A 1 80  ? 129.867 114.973 93.261  1.00 43.76  ? 80  GLU U CG   1 
ATOM   552  C CD   . GLU A 1 80  ? 130.648 113.987 92.417  1.00 52.48  ? 80  GLU U CD   1 
ATOM   553  O OE1  . GLU A 1 80  ? 130.016 113.230 91.649  1.00 52.60  ? 80  GLU U OE1  1 
ATOM   554  O OE2  . GLU A 1 80  ? 131.891 113.967 92.519  1.00 54.36  ? 80  GLU U OE2  1 
ATOM   555  N N    . ALA A 1 81  ? 128.020 118.206 92.955  1.00 43.61  ? 81  ALA U N    1 
ATOM   556  C CA   . ALA A 1 81  ? 128.572 119.555 93.065  1.00 39.40  ? 81  ALA U CA   1 
ATOM   557  C C    . ALA A 1 81  ? 127.929 120.333 94.209  1.00 38.14  ? 81  ALA U C    1 
ATOM   558  O O    . ALA A 1 81  ? 128.617 121.041 94.955  1.00 43.32  ? 81  ALA U O    1 
ATOM   559  C CB   . ALA A 1 81  ? 128.386 120.307 91.749  1.00 35.17  ? 81  ALA U CB   1 
ATOM   560  N N    . THR A 1 82  ? 126.608 120.216 94.354  1.00 41.39  ? 82  THR U N    1 
ATOM   561  C CA   . THR A 1 82  ? 125.892 120.914 95.417  1.00 40.93  ? 82  THR U CA   1 
ATOM   562  C C    . THR A 1 82  ? 126.349 120.443 96.788  1.00 43.17  ? 82  THR U C    1 
ATOM   563  O O    . THR A 1 82  ? 126.425 121.240 97.729  1.00 41.05  ? 82  THR U O    1 
ATOM   564  C CB   . THR A 1 82  ? 124.383 120.711 95.242  1.00 40.54  ? 82  THR U CB   1 
ATOM   565  O OG1  . THR A 1 82  ? 123.927 121.455 94.103  1.00 40.35  ? 82  THR U OG1  1 
ATOM   566  C CG2  . THR A 1 82  ? 123.620 121.169 96.470  1.00 48.00  ? 82  THR U CG2  1 
ATOM   567  N N    . ARG A 1 83  ? 126.687 119.158 96.909  1.00 49.88  ? 83  ARG U N    1 
ATOM   568  C CA   . ARG A 1 83  ? 127.240 118.647 98.156  1.00 42.82  ? 83  ARG U CA   1 
ATOM   569  C C    . ARG A 1 83  ? 128.550 119.324 98.541  1.00 44.01  ? 83  ARG U C    1 
ATOM   570  O O    . ARG A 1 83  ? 128.946 119.262 99.710  1.00 52.86  ? 83  ARG U O    1 
ATOM   571  C CB   . ARG A 1 83  ? 127.452 117.135 98.052  1.00 46.15  ? 83  ARG U CB   1 
ATOM   572  C CG   . ARG A 1 83  ? 126.919 116.349 99.237  1.00 48.75  ? 83  ARG U CG   1 
ATOM   573  C CD   . ARG A 1 83  ? 126.352 115.005 98.801  1.00 52.47  ? 83  ARG U CD   1 
ATOM   574  N NE   . ARG A 1 83  ? 127.243 114.303 97.887  1.00 55.58  ? 83  ARG U NE   1 
ATOM   575  C CZ   . ARG A 1 83  ? 126.840 113.475 96.933  1.00 54.29  ? 83  ARG U CZ   1 
ATOM   576  N NH1  . ARG A 1 83  ? 125.556 113.222 96.736  1.00 50.19  ? 83  ARG U NH1  1 
ATOM   577  N NH2  . ARG A 1 83  ? 127.746 112.885 96.158  1.00 52.03  ? 83  ARG U NH2  1 
ATOM   578  N N    . ALA A 1 84  ? 129.231 119.978 97.598  1.00 41.89  ? 84  ALA U N    1 
ATOM   579  C CA   . ALA A 1 84  ? 130.485 120.659 97.881  1.00 37.35  ? 84  ALA U CA   1 
ATOM   580  C C    . ALA A 1 84  ? 130.342 122.168 98.067  1.00 40.13  ? 84  ALA U C    1 
ATOM   581  O O    . ALA A 1 84  ? 131.354 122.839 98.300  1.00 43.93  ? 84  ALA U O    1 
ATOM   582  C CB   . ALA A 1 84  ? 131.499 120.378 96.768  1.00 39.35  ? 84  ALA U CB   1 
ATOM   583  N N    . GLY A 1 85  ? 129.134 122.718 97.973  1.00 42.48  ? 85  GLY U N    1 
ATOM   584  C CA   . GLY A 1 85  ? 128.916 124.130 98.219  1.00 40.59  ? 85  GLY U CA   1 
ATOM   585  C C    . GLY A 1 85  ? 128.464 124.947 97.026  1.00 43.07  ? 85  GLY U C    1 
ATOM   586  O O    . GLY A 1 85  ? 128.153 126.130 97.201  1.00 51.03  ? 85  GLY U O    1 
ATOM   587  N N    . ILE A 1 86  ? 128.417 124.370 95.827  1.00 40.27  ? 86  ILE U N    1 
ATOM   588  C CA   . ILE A 1 86  ? 128.018 125.127 94.647  1.00 34.34  ? 86  ILE U CA   1 
ATOM   589  C C    . ILE A 1 86  ? 126.521 125.399 94.687  1.00 38.42  ? 86  ILE U C    1 
ATOM   590  O O    . ILE A 1 86  ? 125.714 124.509 94.992  1.00 43.56  ? 86  ILE U O    1 
ATOM   591  C CB   . ILE A 1 86  ? 128.418 124.371 93.369  1.00 38.97  ? 86  ILE U CB   1 
ATOM   592  C CG1  . ILE A 1 86  ? 129.945 124.309 93.250  1.00 38.82  ? 86  ILE U CG1  1 
ATOM   593  C CG2  . ILE A 1 86  ? 127.787 125.006 92.134  1.00 39.05  ? 86  ILE U CG2  1 
ATOM   594  C CD1  . ILE A 1 86  ? 130.557 125.462 92.480  1.00 39.65  ? 86  ILE U CD1  1 
ATOM   595  N N    . ARG A 1 87  ? 126.136 126.639 94.383  1.00 47.26  ? 87  ARG U N    1 
ATOM   596  C CA   . ARG A 1 87  ? 124.733 127.018 94.300  1.00 48.08  ? 87  ARG U CA   1 
ATOM   597  C C    . ARG A 1 87  ? 124.515 127.877 93.062  1.00 48.84  ? 87  ARG U C    1 
ATOM   598  O O    . ARG A 1 87  ? 125.458 128.435 92.494  1.00 52.63  ? 87  ARG U O    1 
ATOM   599  C CB   . ARG A 1 87  ? 124.276 127.777 95.553  1.00 46.28  ? 87  ARG U CB   1 
ATOM   600  C CG   . ARG A 1 87  ? 124.308 126.952 96.827  1.00 46.05  ? 87  ARG U CG   1 
ATOM   601  C CD   . ARG A 1 87  ? 122.964 126.293 97.103  1.00 47.86  ? 87  ARG U CD   1 
ATOM   602  N NE   . ARG A 1 87  ? 122.837 125.796 98.469  1.00 52.95  ? 87  ARG U NE   1 
ATOM   603  C CZ   . ARG A 1 87  ? 123.627 124.884 99.025  1.00 53.81  ? 87  ARG U CZ   1 
ATOM   604  N NH1  . ARG A 1 87  ? 124.598 124.295 98.347  1.00 47.38  ? 87  ARG U NH1  1 
ATOM   605  N NH2  . ARG A 1 87  ? 123.422 124.538 100.293 1.00 54.90  ? 87  ARG U NH2  1 
ATOM   606  N N    . VAL A 1 88  ? 123.252 127.965 92.643  1.00 55.37  ? 88  VAL U N    1 
ATOM   607  C CA   . VAL A 1 88  ? 122.918 128.735 91.448  1.00 56.18  ? 88  VAL U CA   1 
ATOM   608  C C    . VAL A 1 88  ? 123.110 130.233 91.676  1.00 57.51  ? 88  VAL U C    1 
ATOM   609  O O    . VAL A 1 88  ? 123.404 130.976 90.731  1.00 54.82  ? 88  VAL U O    1 
ATOM   610  C CB   . VAL A 1 88  ? 121.488 128.397 90.978  1.00 52.97  ? 88  VAL U CB   1 
ATOM   611  C CG1  . VAL A 1 88  ? 120.451 129.247 91.702  1.00 52.02  ? 88  VAL U CG1  1 
ATOM   612  C CG2  . VAL A 1 88  ? 121.368 128.568 89.475  1.00 51.54  ? 88  VAL U CG2  1 
ATOM   613  N N    . ASP A 1 89  ? 122.955 130.701 92.910  1.00 58.14  ? 89  ASP U N    1 
ATOM   614  C CA   . ASP A 1 89  ? 123.221 132.088 93.260  1.00 56.69  ? 89  ASP U CA   1 
ATOM   615  C C    . ASP A 1 89  ? 124.630 132.240 93.826  1.00 60.16  ? 89  ASP U C    1 
ATOM   616  O O    . ASP A 1 89  ? 125.296 131.264 94.181  1.00 64.96  ? 89  ASP U O    1 
ATOM   617  C CB   . ASP A 1 89  ? 122.182 132.598 94.263  1.00 57.13  ? 89  ASP U CB   1 
ATOM   618  C CG   . ASP A 1 89  ? 120.812 132.786 93.642  1.00 64.20  ? 89  ASP U CG   1 
ATOM   619  O OD1  . ASP A 1 89  ? 120.742 133.067 92.424  1.00 63.97  ? 89  ASP U OD1  1 
ATOM   620  O OD2  . ASP A 1 89  ? 119.805 132.657 94.368  1.00 66.61  ? 89  ASP U OD2  1 
ATOM   621  N N    . ASN A 1 90  ? 125.082 133.489 93.903  1.00 57.60  ? 90  ASN U N    1 
ATOM   622  C CA   . ASN A 1 90  ? 126.409 133.776 94.432  1.00 54.35  ? 90  ASN U CA   1 
ATOM   623  C C    . ASN A 1 90  ? 126.412 133.598 95.943  1.00 53.43  ? 90  ASN U C    1 
ATOM   624  O O    . ASN A 1 90  ? 125.629 134.239 96.652  1.00 57.20  ? 90  ASN U O    1 
ATOM   625  C CB   . ASN A 1 90  ? 126.832 135.196 94.059  1.00 58.23  ? 90  ASN U CB   1 
ATOM   626  C CG   . ASN A 1 90  ? 126.832 135.430 92.563  1.00 60.95  ? 90  ASN U CG   1 
ATOM   627  O OD1  . ASN A 1 90  ? 126.297 134.629 91.798  1.00 62.03  ? 90  ASN U OD1  1 
ATOM   628  N ND2  . ASN A 1 90  ? 127.426 136.539 92.140  1.00 58.04  ? 90  ASN U ND2  1 
ATOM   629  N N    . VAL A 1 91  ? 127.300 132.738 96.442  1.00 40.53  ? 91  VAL U N    1 
ATOM   630  C CA   . VAL A 1 91  ? 127.412 132.470 97.867  1.00 40.05  ? 91  VAL U CA   1 
ATOM   631  C C    . VAL A 1 91  ? 128.870 132.609 98.284  1.00 36.80  ? 91  VAL U C    1 
ATOM   632  O O    . VAL A 1 91  ? 129.791 132.500 97.471  1.00 37.95  ? 91  VAL U O    1 
ATOM   633  C CB   . VAL A 1 91  ? 126.873 131.076 98.254  1.00 38.35  ? 91  VAL U CB   1 
ATOM   634  C CG1  . VAL A 1 91  ? 125.378 130.988 97.982  1.00 40.14  ? 91  VAL U CG1  1 
ATOM   635  C CG2  . VAL A 1 91  ? 127.616 129.986 97.503  1.00 41.74  ? 91  VAL U CG2  1 
ATOM   636  N N    . ARG A 1 92  ? 129.065 132.863 99.575  1.00 35.00  ? 92  ARG U N    1 
ATOM   637  C CA   . ARG A 1 92  ? 130.399 133.046 100.114 1.00 30.75  ? 92  ARG U CA   1 
ATOM   638  C C    . ARG A 1 92  ? 131.187 131.735 100.057 1.00 38.89  ? 92  ARG U C    1 
ATOM   639  O O    . ARG A 1 92  ? 130.607 130.647 100.102 1.00 47.06  ? 92  ARG U O    1 
ATOM   640  C CB   . ARG A 1 92  ? 130.310 133.555 101.551 1.00 31.55  ? 92  ARG U CB   1 
ATOM   641  C CG   . ARG A 1 92  ? 129.688 132.569 102.525 1.00 34.04  ? 92  ARG U CG   1 
ATOM   642  C CD   . ARG A 1 92  ? 129.413 133.217 103.869 1.00 35.87  ? 92  ARG U CD   1 
ATOM   643  N NE   . ARG A 1 92  ? 130.640 133.591 104.561 1.00 40.18  ? 92  ARG U NE   1 
ATOM   644  C CZ   . ARG A 1 92  ? 130.692 134.019 105.815 1.00 36.22  ? 92  ARG U CZ   1 
ATOM   645  N NH1  . ARG A 1 92  ? 129.598 134.128 106.551 1.00 31.46  ? 92  ARG U NH1  1 
ATOM   646  N NH2  . ARG A 1 92  ? 131.868 134.336 106.343 1.00 36.48  ? 92  ARG U NH2  1 
ATOM   647  N N    . PRO A 1 93  ? 132.513 131.813 99.940  1.00 34.48  ? 93  PRO U N    1 
ATOM   648  C CA   . PRO A 1 93  ? 133.323 130.590 99.922  1.00 27.30  ? 93  PRO U CA   1 
ATOM   649  C C    . PRO A 1 93  ? 133.309 129.869 101.262 1.00 29.33  ? 93  PRO U C    1 
ATOM   650  O O    . PRO A 1 93  ? 133.095 130.469 102.318 1.00 40.19  ? 93  PRO U O    1 
ATOM   651  C CB   . PRO A 1 93  ? 134.728 131.100 99.585  1.00 26.21  ? 93  PRO U CB   1 
ATOM   652  C CG   . PRO A 1 93  ? 134.722 132.533 99.997  1.00 31.50  ? 93  PRO U CG   1 
ATOM   653  C CD   . PRO A 1 93  ? 133.329 133.022 99.741  1.00 34.44  ? 93  PRO U CD   1 
ATOM   654  N N    . ARG A 1 94  ? 133.531 128.560 101.203 1.00 31.27  ? 94  ARG U N    1 
ATOM   655  C CA   . ARG A 1 94  ? 133.705 127.743 102.394 1.00 32.39  ? 94  ARG U CA   1 
ATOM   656  C C    . ARG A 1 94  ? 135.178 127.660 102.791 1.00 41.18  ? 94  ARG U C    1 
ATOM   657  O O    . ARG A 1 94  ? 136.080 127.872 101.978 1.00 49.14  ? 94  ARG U O    1 
ATOM   658  C CB   . ARG A 1 94  ? 133.155 126.332 102.169 1.00 31.34  ? 94  ARG U CB   1 
ATOM   659  C CG   . ARG A 1 94  ? 131.685 126.170 102.498 1.00 32.07  ? 94  ARG U CG   1 
ATOM   660  C CD   . ARG A 1 94  ? 130.784 126.497 101.325 1.00 30.05  ? 94  ARG U CD   1 
ATOM   661  N NE   . ARG A 1 94  ? 129.389 126.529 101.744 1.00 32.44  ? 94  ARG U NE   1 
ATOM   662  C CZ   . ARG A 1 94  ? 128.717 127.638 102.027 1.00 35.53  ? 94  ARG U CZ   1 
ATOM   663  N NH1  . ARG A 1 94  ? 129.261 128.834 101.874 1.00 32.71  ? 94  ARG U NH1  1 
ATOM   664  N NH2  . ARG A 1 94  ? 127.468 127.544 102.469 1.00 35.89  ? 94  ARG U NH2  1 
ATOM   665  N N    . TRP A 1 95  ? 135.403 127.347 104.067 1.00 24.64  ? 95  TRP U N    1 
ATOM   666  C CA   . TRP A 1 95  ? 136.711 126.935 104.581 1.00 26.68  ? 95  TRP U CA   1 
ATOM   667  C C    . TRP A 1 95  ? 137.823 127.954 104.325 1.00 29.14  ? 95  TRP U C    1 
ATOM   668  O O    . TRP A 1 95  ? 138.994 127.577 104.245 1.00 40.02  ? 95  TRP U O    1 
ATOM   669  C CB   . TRP A 1 95  ? 137.140 125.578 104.001 1.00 17.07  ? 95  TRP U CB   1 
ATOM   670  C CG   . TRP A 1 95  ? 136.134 124.469 104.105 1.00 21.27  ? 95  TRP U CG   1 
ATOM   671  C CD1  . TRP A 1 95  ? 135.548 123.799 103.070 1.00 23.77  ? 95  TRP U CD1  1 
ATOM   672  C CD2  . TRP A 1 95  ? 135.641 123.857 105.305 1.00 27.78  ? 95  TRP U CD2  1 
ATOM   673  N NE1  . TRP A 1 95  ? 134.702 122.832 103.550 1.00 23.77  ? 95  TRP U NE1  1 
ATOM   674  C CE2  . TRP A 1 95  ? 134.742 122.844 104.920 1.00 27.66  ? 95  TRP U CE2  1 
ATOM   675  C CE3  . TRP A 1 95  ? 135.865 124.078 106.666 1.00 23.21  ? 95  TRP U CE3  1 
ATOM   676  C CZ2  . TRP A 1 95  ? 134.068 122.051 105.845 1.00 24.31  ? 95  TRP U CZ2  1 
ATOM   677  C CZ3  . TRP A 1 95  ? 135.192 123.291 107.586 1.00 20.77  ? 95  TRP U CZ3  1 
ATOM   678  C CH2  . TRP A 1 95  ? 134.305 122.292 107.171 1.00 21.30  ? 95  TRP U CH2  1 
ATOM   679  N N    . ASP A 1 96  ? 137.516 129.245 104.180 1.00 23.57  ? 96  ASP U N    1 
ATOM   680  C CA   . ASP A 1 96  ? 138.626 130.177 103.950 1.00 31.22  ? 96  ASP U CA   1 
ATOM   681  C C    . ASP A 1 96  ? 139.289 130.575 105.265 1.00 41.23  ? 96  ASP U C    1 
ATOM   682  O O    . ASP A 1 96  ? 140.399 130.128 105.574 1.00 51.45  ? 96  ASP U O    1 
ATOM   683  C CB   . ASP A 1 96  ? 138.133 131.415 103.194 1.00 35.77  ? 96  ASP U CB   1 
ATOM   684  C CG   . ASP A 1 96  ? 136.762 131.875 103.649 1.00 42.20  ? 96  ASP U CG   1 
ATOM   685  O OD1  . ASP A 1 96  ? 136.148 131.194 104.492 1.00 43.51  ? 96  ASP U OD1  1 
ATOM   686  O OD2  . ASP A 1 96  ? 136.306 132.932 103.166 1.00 42.58  ? 96  ASP U OD2  1 
ATOM   687  N N    . PHE A 1 97  ? 138.630 131.429 106.051 1.00 34.15  ? 97  PHE U N    1 
ATOM   688  C CA   . PHE A 1 97  ? 138.790 131.460 107.502 1.00 26.36  ? 97  PHE U CA   1 
ATOM   689  C C    . PHE A 1 97  ? 137.505 131.780 108.256 1.00 30.83  ? 97  PHE U C    1 
ATOM   690  O O    . PHE A 1 97  ? 137.367 131.362 109.410 1.00 34.71  ? 97  PHE U O    1 
ATOM   691  C CB   . PHE A 1 97  ? 139.871 132.467 107.920 1.00 26.31  ? 97  PHE U CB   1 
ATOM   692  C CG   . PHE A 1 97  ? 140.133 132.486 109.398 1.00 30.46  ? 97  PHE U CG   1 
ATOM   693  C CD1  . PHE A 1 97  ? 140.912 131.507 109.989 1.00 29.32  ? 97  PHE U CD1  1 
ATOM   694  C CD2  . PHE A 1 97  ? 139.587 133.474 110.200 1.00 30.26  ? 97  PHE U CD2  1 
ATOM   695  C CE1  . PHE A 1 97  ? 141.148 131.515 111.351 1.00 29.47  ? 97  PHE U CE1  1 
ATOM   696  C CE2  . PHE A 1 97  ? 139.820 133.489 111.562 1.00 25.88  ? 97  PHE U CE2  1 
ATOM   697  C CZ   . PHE A 1 97  ? 140.601 132.511 112.138 1.00 27.09  ? 97  PHE U CZ   1 
ATOM   698  N N    . THR A 1 98  ? 136.556 132.487 107.643 1.00 32.10  ? 98  THR U N    1 
ATOM   699  C CA   . THR A 1 98  ? 135.315 132.881 108.291 1.00 33.06  ? 98  THR U CA   1 
ATOM   700  C C    . THR A 1 98  ? 134.205 131.861 108.095 1.00 33.94  ? 98  THR U C    1 
ATOM   701  O O    . THR A 1 98  ? 133.351 131.705 108.978 1.00 39.59  ? 98  THR U O    1 
ATOM   702  C CB   . THR A 1 98  ? 134.862 134.246 107.766 1.00 31.65  ? 98  THR U CB   1 
ATOM   703  O OG1  . THR A 1 98  ? 134.368 134.107 106.429 1.00 38.44  ? 98  THR U OG1  1 
ATOM   704  C CG2  . THR A 1 98  ? 136.021 135.222 107.766 1.00 22.10  ? 98  THR U CG2  1 
ATOM   705  N N    . GLY A 1 99  ? 134.203 131.160 106.963 1.00 26.02  ? 99  GLY U N    1 
ATOM   706  C CA   . GLY A 1 99  ? 133.326 130.012 106.824 1.00 27.63  ? 99  GLY U CA   1 
ATOM   707  C C    . GLY A 1 99  ? 133.635 128.930 107.841 1.00 26.94  ? 99  GLY U C    1 
ATOM   708  O O    . GLY A 1 99  ? 132.728 128.297 108.380 1.00 30.46  ? 99  GLY U O    1 
ATOM   709  N N    . ALA A 1 100 ? 134.921 128.719 108.131 1.00 23.13  ? 100 ALA U N    1 
ATOM   710  C CA   . ALA A 1 100 ? 135.300 127.767 109.170 1.00 23.44  ? 100 ALA U CA   1 
ATOM   711  C C    . ALA A 1 100 ? 134.822 128.225 110.544 1.00 26.83  ? 100 ALA U C    1 
ATOM   712  O O    . ALA A 1 100 ? 134.394 127.402 111.363 1.00 29.76  ? 100 ALA U O    1 
ATOM   713  C CB   . ALA A 1 100 ? 136.815 127.565 109.162 1.00 23.62  ? 100 ALA U CB   1 
ATOM   714  N N    . PHE A 1 101 ? 134.901 129.528 110.819 1.00 18.71  ? 101 PHE U N    1 
ATOM   715  C CA   . PHE A 1 101 ? 134.393 130.060 112.081 1.00 20.81  ? 101 PHE U CA   1 
ATOM   716  C C    . PHE A 1 101 ? 132.887 129.853 112.199 1.00 26.53  ? 101 PHE U C    1 
ATOM   717  O O    . PHE A 1 101 ? 132.389 129.425 113.251 1.00 33.48  ? 101 PHE U O    1 
ATOM   718  C CB   . PHE A 1 101 ? 134.750 131.543 112.194 1.00 22.23  ? 101 PHE U CB   1 
ATOM   719  C CG   . PHE A 1 101 ? 134.578 132.108 113.574 1.00 31.49  ? 101 PHE U CG   1 
ATOM   720  C CD1  . PHE A 1 101 ? 135.549 131.915 114.541 1.00 23.16  ? 101 PHE U CD1  1 
ATOM   721  C CD2  . PHE A 1 101 ? 133.451 132.842 113.900 1.00 29.18  ? 101 PHE U CD2  1 
ATOM   722  C CE1  . PHE A 1 101 ? 135.393 132.432 115.811 1.00 23.67  ? 101 PHE U CE1  1 
ATOM   723  C CE2  . PHE A 1 101 ? 133.290 133.364 115.167 1.00 21.78  ? 101 PHE U CE2  1 
ATOM   724  C CZ   . PHE A 1 101 ? 134.263 133.160 116.123 1.00 25.59  ? 101 PHE U CZ   1 
ATOM   725  N N    . TYR A 1 102 ? 132.150 130.137 111.124 1.00 20.15  ? 102 TYR U N    1 
ATOM   726  C CA   . TYR A 1 102 ? 130.713 129.868 111.106 1.00 24.46  ? 102 TYR U CA   1 
ATOM   727  C C    . TYR A 1 102 ? 130.428 128.386 111.336 1.00 30.55  ? 102 TYR U C    1 
ATOM   728  O O    . TYR A 1 102 ? 129.515 128.029 112.093 1.00 29.35  ? 102 TYR U O    1 
ATOM   729  C CB   . TYR A 1 102 ? 130.127 130.337 109.773 1.00 21.52  ? 102 TYR U CB   1 
ATOM   730  C CG   . TYR A 1 102 ? 128.668 130.749 109.810 1.00 30.51  ? 102 TYR U CG   1 
ATOM   731  C CD1  . TYR A 1 102 ? 127.814 130.284 110.803 1.00 33.47  ? 102 TYR U CD1  1 
ATOM   732  C CD2  . TYR A 1 102 ? 128.149 131.597 108.846 1.00 24.89  ? 102 TYR U CD2  1 
ATOM   733  C CE1  . TYR A 1 102 ? 126.483 130.657 110.831 1.00 32.64  ? 102 TYR U CE1  1 
ATOM   734  C CE2  . TYR A 1 102 ? 126.821 131.977 108.865 1.00 26.44  ? 102 TYR U CE2  1 
ATOM   735  C CZ   . TYR A 1 102 ? 125.995 131.503 109.862 1.00 29.36  ? 102 TYR U CZ   1 
ATOM   736  O OH   . TYR A 1 102 ? 124.672 131.878 109.885 1.00 35.53  ? 102 TYR U OH   1 
ATOM   737  N N    . PHE A 1 103 ? 131.205 127.514 110.692 1.00 24.29  ? 103 PHE U N    1 
ATOM   738  C CA   . PHE A 1 103 ? 131.002 126.073 110.818 1.00 20.28  ? 103 PHE U CA   1 
ATOM   739  C C    . PHE A 1 103 ? 131.215 125.606 112.252 1.00 21.90  ? 103 PHE U C    1 
ATOM   740  O O    . PHE A 1 103 ? 130.389 124.874 112.809 1.00 28.27  ? 103 PHE U O    1 
ATOM   741  C CB   . PHE A 1 103 ? 131.942 125.340 109.859 1.00 20.48  ? 103 PHE U CB   1 
ATOM   742  C CG   . PHE A 1 103 ? 132.019 123.858 110.090 1.00 28.62  ? 103 PHE U CG   1 
ATOM   743  C CD1  . PHE A 1 103 ? 130.975 123.029 109.718 1.00 20.23  ? 103 PHE U CD1  1 
ATOM   744  C CD2  . PHE A 1 103 ? 133.139 123.293 110.677 1.00 26.97  ? 103 PHE U CD2  1 
ATOM   745  C CE1  . PHE A 1 103 ? 131.048 121.664 109.927 1.00 20.76  ? 103 PHE U CE1  1 
ATOM   746  C CE2  . PHE A 1 103 ? 133.218 121.935 110.893 1.00 24.37  ? 103 PHE U CE2  1 
ATOM   747  C CZ   . PHE A 1 103 ? 132.171 121.118 110.516 1.00 23.09  ? 103 PHE U CZ   1 
ATOM   748  N N    . VAL A 1 104 ? 132.322 126.021 112.871 1.00 23.41  ? 104 VAL U N    1 
ATOM   749  C CA   . VAL A 1 104 ? 132.589 125.577 114.237 1.00 24.13  ? 104 VAL U CA   1 
ATOM   750  C C    . VAL A 1 104 ? 131.561 126.161 115.198 1.00 21.55  ? 104 VAL U C    1 
ATOM   751  O O    . VAL A 1 104 ? 131.182 125.507 116.180 1.00 23.96  ? 104 VAL U O    1 
ATOM   752  C CB   . VAL A 1 104 ? 134.036 125.911 114.663 1.00 22.84  ? 104 VAL U CB   1 
ATOM   753  C CG1  . VAL A 1 104 ? 135.033 125.198 113.763 1.00 18.28  ? 104 VAL U CG1  1 
ATOM   754  C CG2  . VAL A 1 104 ? 134.285 127.405 114.672 1.00 18.37  ? 104 VAL U CG2  1 
ATOM   755  N N    . GLY A 1 105 ? 131.092 127.385 114.940 1.00 31.69  ? 105 GLY U N    1 
ATOM   756  C CA   . GLY A 1 105 ? 130.025 127.940 115.756 1.00 20.64  ? 105 GLY U CA   1 
ATOM   757  C C    . GLY A 1 105 ? 128.736 127.143 115.664 1.00 21.40  ? 105 GLY U C    1 
ATOM   758  O O    . GLY A 1 105 ? 128.058 126.924 116.669 1.00 25.60  ? 105 GLY U O    1 
ATOM   759  N N    . THR A 1 106 ? 128.377 126.703 114.452 1.00 29.37  ? 106 THR U N    1 
ATOM   760  C CA   . THR A 1 106 ? 127.191 125.862 114.306 1.00 23.58  ? 106 THR U CA   1 
ATOM   761  C C    . THR A 1 106 ? 127.400 124.482 114.914 1.00 27.21  ? 106 THR U C    1 
ATOM   762  O O    . THR A 1 106 ? 126.427 123.820 115.299 1.00 32.38  ? 106 THR U O    1 
ATOM   763  C CB   . THR A 1 106 ? 126.795 125.727 112.834 1.00 25.07  ? 106 THR U CB   1 
ATOM   764  O OG1  . THR A 1 106 ? 127.884 125.168 112.091 1.00 28.40  ? 106 THR U OG1  1 
ATOM   765  C CG2  . THR A 1 106 ? 126.424 127.079 112.250 1.00 26.50  ? 106 THR U CG2  1 
ATOM   766  N N    . VAL A 1 107 ? 128.650 124.030 115.006 1.00 25.97  ? 107 VAL U N    1 
ATOM   767  C CA   . VAL A 1 107 ? 128.924 122.698 115.536 1.00 15.18  ? 107 VAL U CA   1 
ATOM   768  C C    . VAL A 1 107 ? 128.834 122.693 117.057 1.00 17.40  ? 107 VAL U C    1 
ATOM   769  O O    . VAL A 1 107 ? 128.158 121.844 117.648 1.00 25.07  ? 107 VAL U O    1 
ATOM   770  C CB   . VAL A 1 107 ? 130.298 122.196 115.050 1.00 18.94  ? 107 VAL U CB   1 
ATOM   771  C CG1  . VAL A 1 107 ? 130.784 121.048 115.918 1.00 21.84  ? 107 VAL U CG1  1 
ATOM   772  C CG2  . VAL A 1 107 ? 130.217 121.760 113.598 1.00 18.54  ? 107 VAL U CG2  1 
ATOM   773  N N    . VAL A 1 108 ? 129.506 123.644 117.713 1.00 24.86  ? 108 VAL U N    1 
ATOM   774  C CA   . VAL A 1 108 ? 129.586 123.623 119.171 1.00 21.42  ? 108 VAL U CA   1 
ATOM   775  C C    . VAL A 1 108 ? 128.223 123.883 119.806 1.00 26.22  ? 108 VAL U C    1 
ATOM   776  O O    . VAL A 1 108 ? 127.953 123.424 120.920 1.00 30.03  ? 108 VAL U O    1 
ATOM   777  C CB   . VAL A 1 108 ? 130.639 124.630 119.677 1.00 17.79  ? 108 VAL U CB   1 
ATOM   778  C CG1  . VAL A 1 108 ? 132.022 124.247 119.173 1.00 18.85  ? 108 VAL U CG1  1 
ATOM   779  C CG2  . VAL A 1 108 ? 130.275 126.047 119.261 1.00 18.11  ? 108 VAL U CG2  1 
ATOM   780  N N    . SER A 1 109 ? 127.347 124.620 119.125 1.00 29.84  ? 109 SER U N    1 
ATOM   781  C CA   . SER A 1 109 ? 126.008 124.897 119.626 1.00 19.81  ? 109 SER U CA   1 
ATOM   782  C C    . SER A 1 109 ? 124.997 123.810 119.273 1.00 25.93  ? 109 SER U C    1 
ATOM   783  O O    . SER A 1 109 ? 123.828 123.932 119.649 1.00 26.90  ? 109 SER U O    1 
ATOM   784  C CB   . SER A 1 109 ? 125.517 126.242 119.085 1.00 23.94  ? 109 SER U CB   1 
ATOM   785  O OG   . SER A 1 109 ? 125.569 126.265 117.671 1.00 23.82  ? 109 SER U OG   1 
ATOM   786  N N    . THR A 1 110 ? 125.426 122.749 118.587 1.00 29.78  ? 110 THR U N    1 
ATOM   787  C CA   . THR A 1 110 ? 124.558 121.645 118.148 1.00 26.17  ? 110 THR U CA   1 
ATOM   788  C C    . THR A 1 110 ? 123.374 122.146 117.326 1.00 24.62  ? 110 THR U C    1 
ATOM   789  O O    . THR A 1 110 ? 122.264 121.612 117.404 1.00 33.57  ? 110 THR U O    1 
ATOM   790  C CB   . THR A 1 110 ? 124.073 120.789 119.327 1.00 29.82  ? 110 THR U CB   1 
ATOM   791  O OG1  . THR A 1 110 ? 123.676 121.620 120.424 1.00 35.96  ? 110 THR U OG1  1 
ATOM   792  C CG2  . THR A 1 110 ? 125.167 119.842 119.789 1.00 27.26  ? 110 THR U CG2  1 
ATOM   793  N N    . ILE A 1 111 ? 123.610 123.174 116.515 1.00 14.87  ? 111 ILE U N    1 
ATOM   794  C CA   . ILE A 1 111 ? 122.596 123.636 115.571 1.00 19.30  ? 111 ILE U CA   1 
ATOM   795  C C    . ILE A 1 111 ? 122.616 122.774 114.316 1.00 28.91  ? 111 ILE U C    1 
ATOM   796  O O    . ILE A 1 111 ? 121.593 122.215 113.902 1.00 35.69  ? 111 ILE U O    1 
ATOM   797  C CB   . ILE A 1 111 ? 122.796 125.128 115.246 1.00 27.41  ? 111 ILE U CB   1 
ATOM   798  C CG1  . ILE A 1 111 ? 122.518 125.979 116.487 1.00 28.99  ? 111 ILE U CG1  1 
ATOM   799  C CG2  . ILE A 1 111 ? 121.895 125.550 114.095 1.00 17.79  ? 111 ILE U CG2  1 
ATOM   800  C CD1  . ILE A 1 111 ? 122.672 127.464 116.260 1.00 25.36  ? 111 ILE U CD1  1 
ATOM   801  N N    . GLY A 1 112 ? 123.783 122.665 113.689 1.00 25.14  ? 112 GLY U N    1 
ATOM   802  C CA   . GLY A 1 112 ? 123.980 121.797 112.544 1.00 17.29  ? 112 GLY U CA   1 
ATOM   803  C C    . GLY A 1 112 ? 123.200 122.108 111.286 1.00 23.62  ? 112 GLY U C    1 
ATOM   804  O O    . GLY A 1 112 ? 122.529 121.224 110.746 1.00 30.88  ? 112 GLY U O    1 
ATOM   805  N N    . PHE A 1 113 ? 123.261 123.362 110.824 1.00 27.26  ? 113 PHE U N    1 
ATOM   806  C CA   . PHE A 1 113 ? 122.521 123.772 109.632 1.00 21.69  ? 113 PHE U CA   1 
ATOM   807  C C    . PHE A 1 113 ? 122.731 122.797 108.478 1.00 29.65  ? 113 PHE U C    1 
ATOM   808  O O    . PHE A 1 113 ? 121.791 122.490 107.734 1.00 35.52  ? 113 PHE U O    1 
ATOM   809  C CB   . PHE A 1 113 ? 122.924 125.187 109.215 1.00 20.93  ? 113 PHE U CB   1 
ATOM   810  C CG   . PHE A 1 113 ? 122.263 126.270 110.016 1.00 31.55  ? 113 PHE U CG   1 
ATOM   811  C CD1  . PHE A 1 113 ? 120.918 126.192 110.330 1.00 37.21  ? 113 PHE U CD1  1 
ATOM   812  C CD2  . PHE A 1 113 ? 122.983 127.373 110.445 1.00 30.69  ? 113 PHE U CD2  1 
ATOM   813  C CE1  . PHE A 1 113 ? 120.302 127.190 111.060 1.00 32.78  ? 113 PHE U CE1  1 
ATOM   814  C CE2  . PHE A 1 113 ? 122.372 128.375 111.177 1.00 27.63  ? 113 PHE U CE2  1 
ATOM   815  C CZ   . PHE A 1 113 ? 121.030 128.281 111.483 1.00 28.67  ? 113 PHE U CZ   1 
ATOM   816  N N    . GLY A 1 114 ? 123.959 122.311 108.303 1.00 28.40  ? 114 GLY U N    1 
ATOM   817  C CA   . GLY A 1 114 ? 124.290 121.423 107.212 1.00 30.73  ? 114 GLY U CA   1 
ATOM   818  C C    . GLY A 1 114 ? 124.750 122.088 105.935 1.00 31.47  ? 114 GLY U C    1 
ATOM   819  O O    . GLY A 1 114 ? 125.044 121.382 104.962 1.00 36.47  ? 114 GLY U O    1 
ATOM   820  N N    . MET A 1 115 ? 124.805 123.422 105.893 1.00 29.30  ? 115 MET U N    1 
ATOM   821  C CA   . MET A 1 115 ? 125.318 124.105 104.713 1.00 28.12  ? 115 MET U CA   1 
ATOM   822  C C    . MET A 1 115 ? 126.797 123.820 104.472 1.00 32.04  ? 115 MET U C    1 
ATOM   823  O O    . MET A 1 115 ? 127.273 123.995 103.345 1.00 35.49  ? 115 MET U O    1 
ATOM   824  C CB   . MET A 1 115 ? 125.085 125.614 104.834 1.00 27.42  ? 115 MET U CB   1 
ATOM   825  C CG   . MET A 1 115 ? 126.134 126.357 105.645 1.00 31.99  ? 115 MET U CG   1 
ATOM   826  S SD   . MET A 1 115 ? 125.816 126.320 107.416 1.00 47.55  ? 115 MET U SD   1 
ATOM   827  C CE   . MET A 1 115 ? 127.146 127.353 108.021 1.00 24.77  ? 115 MET U CE   1 
ATOM   828  N N    . THR A 1 116 ? 127.530 123.387 105.495 1.00 30.17  ? 116 THR U N    1 
ATOM   829  C CA   . THR A 1 116 ? 128.956 123.100 105.377 1.00 23.56  ? 116 THR U CA   1 
ATOM   830  C C    . THR A 1 116 ? 129.269 121.856 106.196 1.00 27.59  ? 116 THR U C    1 
ATOM   831  O O    . THR A 1 116 ? 129.046 121.846 107.413 1.00 35.87  ? 116 THR U O    1 
ATOM   832  C CB   . THR A 1 116 ? 129.801 124.288 105.852 1.00 21.09  ? 116 THR U CB   1 
ATOM   833  O OG1  . THR A 1 116 ? 129.390 125.474 105.160 1.00 33.26  ? 116 THR U OG1  1 
ATOM   834  C CG2  . THR A 1 116 ? 131.270 124.043 105.572 1.00 18.20  ? 116 THR U CG2  1 
ATOM   835  N N    . THR A 1 117 ? 129.765 120.812 105.540 1.00 31.30  ? 117 THR U N    1 
ATOM   836  C CA   . THR A 1 117 ? 130.064 119.547 106.195 1.00 27.19  ? 117 THR U CA   1 
ATOM   837  C C    . THR A 1 117 ? 131.441 119.041 105.789 1.00 30.12  ? 117 THR U C    1 
ATOM   838  O O    . THR A 1 117 ? 131.903 119.308 104.673 1.00 28.41  ? 117 THR U O    1 
ATOM   839  C CB   . THR A 1 117 ? 129.011 118.480 105.850 1.00 26.57  ? 117 THR U CB   1 
ATOM   840  O OG1  . THR A 1 117 ? 128.708 118.538 104.451 1.00 40.61  ? 117 THR U OG1  1 
ATOM   841  C CG2  . THR A 1 117 ? 127.742 118.709 106.648 1.00 21.60  ? 117 THR U CG2  1 
ATOM   842  N N    . PRO A 1 118 ? 132.122 118.312 106.674 1.00 30.04  ? 118 PRO U N    1 
ATOM   843  C CA   . PRO A 1 118 ? 133.405 117.701 106.303 1.00 27.21  ? 118 PRO U CA   1 
ATOM   844  C C    . PRO A 1 118 ? 133.239 116.665 105.204 1.00 28.87  ? 118 PRO U C    1 
ATOM   845  O O    . PRO A 1 118 ? 132.244 115.939 105.151 1.00 35.99  ? 118 PRO U O    1 
ATOM   846  C CB   . PRO A 1 118 ? 133.889 117.063 107.611 1.00 24.75  ? 118 PRO U CB   1 
ATOM   847  C CG   . PRO A 1 118 ? 133.122 117.753 108.690 1.00 28.98  ? 118 PRO U CG   1 
ATOM   848  C CD   . PRO A 1 118 ? 131.794 118.085 108.091 1.00 29.64  ? 118 PRO U CD   1 
ATOM   849  N N    . ALA A 1 119 ? 134.239 116.586 104.323 1.00 24.35  ? 119 ALA U N    1 
ATOM   850  C CA   . ALA A 1 119 ? 134.192 115.674 103.191 1.00 25.87  ? 119 ALA U CA   1 
ATOM   851  C C    . ALA A 1 119 ? 135.413 114.772 103.051 1.00 33.19  ? 119 ALA U C    1 
ATOM   852  O O    . ALA A 1 119 ? 135.466 113.985 102.099 1.00 41.40  ? 119 ALA U O    1 
ATOM   853  C CB   . ALA A 1 119 ? 134.002 116.457 101.884 1.00 30.10  ? 119 ALA U CB   1 
ATOM   854  N N    . THR A 1 120 ? 136.382 114.851 103.956 1.00 32.22  ? 120 THR U N    1 
ATOM   855  C CA   . THR A 1 120 ? 137.605 114.070 103.852 1.00 30.23  ? 120 THR U CA   1 
ATOM   856  C C    . THR A 1 120 ? 137.802 113.221 105.100 1.00 33.79  ? 120 THR U C    1 
ATOM   857  O O    . THR A 1 120 ? 137.317 113.555 106.183 1.00 40.07  ? 120 THR U O    1 
ATOM   858  C CB   . THR A 1 120 ? 138.838 114.969 103.651 1.00 30.58  ? 120 THR U CB   1 
ATOM   859  O OG1  . THR A 1 120 ? 139.026 115.791 104.808 1.00 26.06  ? 120 THR U OG1  1 
ATOM   860  C CG2  . THR A 1 120 ? 138.664 115.853 102.429 1.00 29.03  ? 120 THR U CG2  1 
ATOM   861  N N    . VAL A 1 121 ? 138.510 112.106 104.930 1.00 37.91  ? 121 VAL U N    1 
ATOM   862  C CA   . VAL A 1 121 ? 138.956 111.311 106.069 1.00 32.37  ? 121 VAL U CA   1 
ATOM   863  C C    . VAL A 1 121 ? 140.065 112.073 106.784 1.00 39.22  ? 121 VAL U C    1 
ATOM   864  O O    . VAL A 1 121 ? 141.079 112.438 106.179 1.00 42.33  ? 121 VAL U O    1 
ATOM   865  C CB   . VAL A 1 121 ? 139.432 109.923 105.622 1.00 33.60  ? 121 VAL U CB   1 
ATOM   866  C CG1  . VAL A 1 121 ? 140.114 109.199 106.775 1.00 32.03  ? 121 VAL U CG1  1 
ATOM   867  C CG2  . VAL A 1 121 ? 138.268 109.107 105.092 1.00 37.47  ? 121 VAL U CG2  1 
ATOM   868  N N    . GLY A 1 122 ? 139.872 112.318 108.074 1.00 30.56  ? 122 GLY U N    1 
ATOM   869  C CA   . GLY A 1 122 ? 140.768 113.167 108.829 1.00 25.90  ? 122 GLY U CA   1 
ATOM   870  C C    . GLY A 1 122 ? 140.022 114.378 109.347 1.00 31.90  ? 122 GLY U C    1 
ATOM   871  O O    . GLY A 1 122 ? 140.195 114.786 110.498 1.00 43.82  ? 122 GLY U O    1 
ATOM   872  N N    . GLY A 1 123 ? 139.172 114.948 108.494 1.00 23.97  ? 123 GLY U N    1 
ATOM   873  C CA   . GLY A 1 123 ? 138.234 115.972 108.911 1.00 22.86  ? 123 GLY U CA   1 
ATOM   874  C C    . GLY A 1 123 ? 136.995 115.452 109.599 1.00 28.22  ? 123 GLY U C    1 
ATOM   875  O O    . GLY A 1 123 ? 136.275 116.238 110.221 1.00 32.49  ? 123 GLY U O    1 
ATOM   876  N N    . LYS A 1 124 ? 136.736 114.146 109.517 1.00 32.30  ? 124 LYS U N    1 
ATOM   877  C CA   . LYS A 1 124 ? 135.606 113.530 110.204 1.00 27.53  ? 124 LYS U CA   1 
ATOM   878  C C    . LYS A 1 124 ? 136.003 112.969 111.565 1.00 31.78  ? 124 LYS U C    1 
ATOM   879  O O    . LYS A 1 124 ? 135.202 113.008 112.503 1.00 34.08  ? 124 LYS U O    1 
ATOM   880  C CB   . LYS A 1 124 ? 135.002 112.425 109.337 1.00 26.83  ? 124 LYS U CB   1 
ATOM   881  C CG   . LYS A 1 124 ? 134.411 112.928 108.035 1.00 24.30  ? 124 LYS U CG   1 
ATOM   882  C CD   . LYS A 1 124 ? 133.734 111.811 107.264 1.00 21.48  ? 124 LYS U CD   1 
ATOM   883  C CE   . LYS A 1 124 ? 133.060 112.352 106.017 1.00 25.22  ? 124 LYS U CE   1 
ATOM   884  N NZ   . LYS A 1 124 ? 132.426 111.275 105.216 1.00 30.22  ? 124 LYS U NZ   1 
ATOM   885  N N    . ILE A 1 125 ? 137.221 112.440 111.691 1.00 25.97  ? 125 ILE U N    1 
ATOM   886  C CA   . ILE A 1 125 ? 137.725 112.048 113.004 1.00 25.92  ? 125 ILE U CA   1 
ATOM   887  C C    . ILE A 1 125 ? 137.904 113.285 113.876 1.00 31.30  ? 125 ILE U C    1 
ATOM   888  O O    . ILE A 1 125 ? 137.484 113.320 115.044 1.00 33.77  ? 125 ILE U O    1 
ATOM   889  C CB   . ILE A 1 125 ? 139.043 111.264 112.860 1.00 23.43  ? 125 ILE U CB   1 
ATOM   890  C CG1  . ILE A 1 125 ? 138.936 110.242 111.727 1.00 19.28  ? 125 ILE U CG1  1 
ATOM   891  C CG2  . ILE A 1 125 ? 139.399 110.573 114.163 1.00 31.79  ? 125 ILE U CG2  1 
ATOM   892  C CD1  . ILE A 1 125 ? 140.237 109.544 111.426 1.00 22.18  ? 125 ILE U CD1  1 
ATOM   893  N N    . PHE A 1 126 ? 138.529 114.322 113.312 1.00 24.97  ? 126 PHE U N    1 
ATOM   894  C CA   . PHE A 1 126 ? 138.706 115.569 114.043 1.00 26.21  ? 126 PHE U CA   1 
ATOM   895  C C    . PHE A 1 126 ? 137.366 116.196 114.385 1.00 25.12  ? 126 PHE U C    1 
ATOM   896  O O    . PHE A 1 126 ? 137.224 116.807 115.446 1.00 31.02  ? 126 PHE U O    1 
ATOM   897  C CB   . PHE A 1 126 ? 139.559 116.541 113.227 1.00 23.24  ? 126 PHE U CB   1 
ATOM   898  C CG   . PHE A 1 126 ? 139.923 117.797 113.967 1.00 27.70  ? 126 PHE U CG   1 
ATOM   899  C CD1  . PHE A 1 126 ? 140.799 117.758 115.041 1.00 25.86  ? 126 PHE U CD1  1 
ATOM   900  C CD2  . PHE A 1 126 ? 139.391 119.017 113.586 1.00 27.93  ? 126 PHE U CD2  1 
ATOM   901  C CE1  . PHE A 1 126 ? 141.130 118.913 115.720 1.00 25.38  ? 126 PHE U CE1  1 
ATOM   902  C CE2  . PHE A 1 126 ? 139.720 120.172 114.261 1.00 23.71  ? 126 PHE U CE2  1 
ATOM   903  C CZ   . PHE A 1 126 ? 140.589 120.121 115.330 1.00 29.01  ? 126 PHE U CZ   1 
ATOM   904  N N    . LEU A 1 127 ? 136.367 116.044 113.512 1.00 17.26  ? 127 LEU U N    1 
ATOM   905  C CA   . LEU A 1 127 ? 135.026 116.522 113.829 1.00 22.32  ? 127 LEU U CA   1 
ATOM   906  C C    . LEU A 1 127 ? 134.479 115.820 115.066 1.00 27.70  ? 127 LEU U C    1 
ATOM   907  O O    . LEU A 1 127 ? 133.914 116.462 115.960 1.00 32.59  ? 127 LEU U O    1 
ATOM   908  C CB   . LEU A 1 127 ? 134.101 116.312 112.631 1.00 24.52  ? 127 LEU U CB   1 
ATOM   909  C CG   . LEU A 1 127 ? 132.692 116.923 112.639 1.00 23.12  ? 127 LEU U CG   1 
ATOM   910  C CD1  . LEU A 1 127 ? 131.663 115.963 113.223 1.00 22.65  ? 127 LEU U CD1  1 
ATOM   911  C CD2  . LEU A 1 127 ? 132.670 118.249 113.382 1.00 24.77  ? 127 LEU U CD2  1 
ATOM   912  N N    . ILE A 1 128 ? 134.669 114.501 115.144 1.00 28.12  ? 128 ILE U N    1 
ATOM   913  C CA   . ILE A 1 128 ? 134.157 113.727 116.272 1.00 27.24  ? 128 ILE U CA   1 
ATOM   914  C C    . ILE A 1 128 ? 134.817 114.184 117.566 1.00 28.67  ? 128 ILE U C    1 
ATOM   915  O O    . ILE A 1 128 ? 134.138 114.480 118.559 1.00 27.72  ? 128 ILE U O    1 
ATOM   916  C CB   . ILE A 1 128 ? 134.364 112.224 116.029 1.00 25.00  ? 128 ILE U CB   1 
ATOM   917  C CG1  . ILE A 1 128 ? 133.442 111.737 114.907 1.00 25.09  ? 128 ILE U CG1  1 
ATOM   918  C CG2  . ILE A 1 128 ? 134.122 111.432 117.302 1.00 23.74  ? 128 ILE U CG2  1 
ATOM   919  C CD1  . ILE A 1 128 ? 133.612 110.277 114.566 1.00 20.82  ? 128 ILE U CD1  1 
ATOM   920  N N    . PHE A 1 129 ? 136.150 114.261 117.569 1.00 29.90  ? 129 PHE U N    1 
ATOM   921  C CA   . PHE A 1 129 ? 136.850 114.658 118.791 1.00 25.51  ? 129 PHE U CA   1 
ATOM   922  C C    . PHE A 1 129 ? 136.532 116.104 119.174 1.00 27.53  ? 129 PHE U C    1 
ATOM   923  O O    . PHE A 1 129 ? 136.320 116.410 120.356 1.00 30.56  ? 129 PHE U O    1 
ATOM   924  C CB   . PHE A 1 129 ? 138.355 114.458 118.623 1.00 24.33  ? 129 PHE U CB   1 
ATOM   925  C CG   . PHE A 1 129 ? 138.793 113.027 118.741 1.00 28.40  ? 129 PHE U CG   1 
ATOM   926  C CD1  . PHE A 1 129 ? 138.782 112.191 117.639 1.00 31.13  ? 129 PHE U CD1  1 
ATOM   927  C CD2  . PHE A 1 129 ? 139.205 112.513 119.960 1.00 33.80  ? 129 PHE U CD2  1 
ATOM   928  C CE1  . PHE A 1 129 ? 139.181 110.872 117.746 1.00 34.27  ? 129 PHE U CE1  1 
ATOM   929  C CE2  . PHE A 1 129 ? 139.603 111.196 120.073 1.00 34.55  ? 129 PHE U CE2  1 
ATOM   930  C CZ   . PHE A 1 129 ? 139.591 110.374 118.964 1.00 34.70  ? 129 PHE U CZ   1 
ATOM   931  N N    . TYR A 1 130 ? 136.479 117.003 118.187 1.00 25.83  ? 130 TYR U N    1 
ATOM   932  C CA   . TYR A 1 130 ? 136.174 118.404 118.448 1.00 24.76  ? 130 TYR U CA   1 
ATOM   933  C C    . TYR A 1 130 ? 134.798 118.558 119.083 1.00 27.20  ? 130 TYR U C    1 
ATOM   934  O O    . TYR A 1 130 ? 134.640 119.269 120.080 1.00 28.21  ? 130 TYR U O    1 
ATOM   935  C CB   . TYR A 1 130 ? 136.262 119.194 117.141 1.00 16.82  ? 130 TYR U CB   1 
ATOM   936  C CG   . TYR A 1 130 ? 136.303 120.695 117.302 1.00 24.13  ? 130 TYR U CG   1 
ATOM   937  C CD1  . TYR A 1 130 ? 137.495 121.351 117.580 1.00 25.00  ? 130 TYR U CD1  1 
ATOM   938  C CD2  . TYR A 1 130 ? 135.151 121.458 117.167 1.00 23.41  ? 130 TYR U CD2  1 
ATOM   939  C CE1  . TYR A 1 130 ? 137.537 122.722 117.725 1.00 19.82  ? 130 TYR U CE1  1 
ATOM   940  C CE2  . TYR A 1 130 ? 135.185 122.832 117.311 1.00 24.53  ? 130 TYR U CE2  1 
ATOM   941  C CZ   . TYR A 1 130 ? 136.380 123.455 117.589 1.00 22.75  ? 130 TYR U CZ   1 
ATOM   942  O OH   . TYR A 1 130 ? 136.412 124.822 117.730 1.00 31.96  ? 130 TYR U OH   1 
ATOM   943  N N    . GLY A 1 131 ? 133.785 117.889 118.523 1.00 22.88  ? 131 GLY U N    1 
ATOM   944  C CA   . GLY A 1 131 ? 132.457 117.968 119.108 1.00 19.75  ? 131 GLY U CA   1 
ATOM   945  C C    . GLY A 1 131 ? 132.399 117.360 120.494 1.00 21.49  ? 131 GLY U C    1 
ATOM   946  O O    . GLY A 1 131 ? 131.792 117.931 121.410 1.00 26.60  ? 131 GLY U O    1 
ATOM   947  N N    . LEU A 1 132 ? 133.064 116.213 120.674 1.00 26.51  ? 132 LEU U N    1 
ATOM   948  C CA   . LEU A 1 132 ? 133.073 115.524 121.960 1.00 26.04  ? 132 LEU U CA   1 
ATOM   949  C C    . LEU A 1 132 ? 133.675 116.396 123.054 1.00 23.60  ? 132 LEU U C    1 
ATOM   950  O O    . LEU A 1 132 ? 133.256 116.327 124.215 1.00 29.30  ? 132 LEU U O    1 
ATOM   951  C CB   . LEU A 1 132 ? 133.839 114.210 121.837 1.00 25.86  ? 132 LEU U CB   1 
ATOM   952  C CG   . LEU A 1 132 ? 133.731 113.210 122.991 1.00 29.52  ? 132 LEU U CG   1 
ATOM   953  C CD1  . LEU A 1 132 ? 132.345 112.594 123.038 1.00 29.89  ? 132 LEU U CD1  1 
ATOM   954  C CD2  . LEU A 1 132 ? 134.794 112.133 122.857 1.00 30.54  ? 132 LEU U CD2  1 
ATOM   955  N N    . VAL A 1 133 ? 134.677 117.207 122.711 1.00 30.06  ? 133 VAL U N    1 
ATOM   956  C CA   . VAL A 1 133 ? 135.265 118.097 123.708 1.00 27.39  ? 133 VAL U CA   1 
ATOM   957  C C    . VAL A 1 133 ? 134.536 119.437 123.818 1.00 29.19  ? 133 VAL U C    1 
ATOM   958  O O    . VAL A 1 133 ? 134.593 120.079 124.877 1.00 25.34  ? 133 VAL U O    1 
ATOM   959  C CB   . VAL A 1 133 ? 136.760 118.331 123.417 1.00 27.89  ? 133 VAL U CB   1 
ATOM   960  C CG1  . VAL A 1 133 ? 137.426 119.088 124.558 1.00 21.06  ? 133 VAL U CG1  1 
ATOM   961  C CG2  . VAL A 1 133 ? 137.471 117.005 123.203 1.00 26.65  ? 133 VAL U CG2  1 
ATOM   962  N N    . GLY A 1 134 ? 133.803 119.849 122.784 1.00 28.23  ? 134 GLY U N    1 
ATOM   963  C CA   . GLY A 1 134 ? 133.258 121.195 122.758 1.00 16.94  ? 134 GLY U CA   1 
ATOM   964  C C    . GLY A 1 134 ? 131.799 121.393 123.120 1.00 21.53  ? 134 GLY U C    1 
ATOM   965  O O    . GLY A 1 134 ? 131.441 122.465 123.624 1.00 24.13  ? 134 GLY U O    1 
ATOM   966  N N    . CYS A 1 135 ? 130.940 120.405 122.870 1.00 25.79  ? 135 CYS U N    1 
ATOM   967  C CA   . CYS A 1 135 ? 129.529 120.563 123.226 1.00 22.99  ? 135 CYS U CA   1 
ATOM   968  C C    . CYS A 1 135 ? 129.279 120.695 124.729 1.00 30.57  ? 135 CYS U C    1 
ATOM   969  O O    . CYS A 1 135 ? 128.498 121.582 125.127 1.00 37.05  ? 135 CYS U O    1 
ATOM   970  C CB   . CYS A 1 135 ? 128.721 119.407 122.624 1.00 29.67  ? 135 CYS U CB   1 
ATOM   971  S SG   . CYS A 1 135 ? 128.754 119.340 120.817 1.00 33.91  ? 135 CYS U SG   1 
ATOM   972  N N    . PRO A 1 136 ? 129.882 119.880 125.607 1.00 26.56  ? 136 PRO U N    1 
ATOM   973  C CA   . PRO A 1 136 ? 129.673 120.096 127.051 1.00 17.63  ? 136 PRO U CA   1 
ATOM   974  C C    . PRO A 1 136 ? 130.090 121.472 127.545 1.00 23.78  ? 136 PRO U C    1 
ATOM   975  O O    . PRO A 1 136 ? 129.456 122.002 128.465 1.00 33.79  ? 136 PRO U O    1 
ATOM   976  C CB   . PRO A 1 136 ? 130.523 118.987 127.690 1.00 24.83  ? 136 PRO U CB   1 
ATOM   977  C CG   . PRO A 1 136 ? 130.582 117.928 126.653 1.00 20.88  ? 136 PRO U CG   1 
ATOM   978  C CD   . PRO A 1 136 ? 130.650 118.648 125.351 1.00 16.84  ? 136 PRO U CD   1 
ATOM   979  N N    . SER A 1 137 ? 131.132 122.072 126.965 1.00 19.65  ? 137 SER U N    1 
ATOM   980  C CA   . SER A 1 137 ? 131.528 123.415 127.378 1.00 17.45  ? 137 SER U CA   1 
ATOM   981  C C    . SER A 1 137 ? 130.428 124.430 127.087 1.00 24.73  ? 137 SER U C    1 
ATOM   982  O O    . SER A 1 137 ? 130.145 125.304 127.913 1.00 38.69  ? 137 SER U O    1 
ATOM   983  C CB   . SER A 1 137 ? 132.831 123.814 126.684 1.00 26.16  ? 137 SER U CB   1 
ATOM   984  O OG   . SER A 1 137 ? 133.815 122.807 126.836 1.00 33.18  ? 137 SER U OG   1 
ATOM   985  N N    . THR A 1 138 ? 129.791 124.323 125.921 1.00 19.29  ? 138 THR U N    1 
ATOM   986  C CA   . THR A 1 138 ? 128.707 125.241 125.585 1.00 24.56  ? 138 THR U CA   1 
ATOM   987  C C    . THR A 1 138 ? 127.485 125.003 126.464 1.00 23.27  ? 138 THR U C    1 
ATOM   988  O O    . THR A 1 138 ? 126.800 125.956 126.863 1.00 29.21  ? 138 THR U O    1 
ATOM   989  C CB   . THR A 1 138 ? 128.348 125.099 124.105 1.00 27.23  ? 138 THR U CB   1 
ATOM   990  O OG1  . THR A 1 138 ? 129.550 125.019 123.331 1.00 26.68  ? 138 THR U OG1  1 
ATOM   991  C CG2  . THR A 1 138 ? 127.528 126.289 123.634 1.00 25.72  ? 138 THR U CG2  1 
ATOM   992  N N    . ILE A 1 139 ? 127.199 123.739 126.792 1.00 19.80  ? 139 ILE U N    1 
ATOM   993  C CA   . ILE A 1 139 ? 126.100 123.454 127.717 1.00 24.65  ? 139 ILE U CA   1 
ATOM   994  C C    . ILE A 1 139 ? 126.368 124.096 129.077 1.00 30.49  ? 139 ILE U C    1 
ATOM   995  O O    . ILE A 1 139 ? 125.477 124.711 129.685 1.00 33.83  ? 139 ILE U O    1 
ATOM   996  C CB   . ILE A 1 139 ? 125.885 121.933 127.832 1.00 26.16  ? 139 ILE U CB   1 
ATOM   997  C CG1  . ILE A 1 139 ? 125.428 121.361 126.491 1.00 21.75  ? 139 ILE U CG1  1 
ATOM   998  C CG2  . ILE A 1 139 ? 124.868 121.616 128.913 1.00 27.04  ? 139 ILE U CG2  1 
ATOM   999  C CD1  . ILE A 1 139 ? 125.252 119.860 126.495 1.00 21.70  ? 139 ILE U CD1  1 
ATOM   1000 N N    . LEU A 1 140 ? 127.602 123.968 129.571 1.00 22.50  ? 140 LEU U N    1 
ATOM   1001 C CA   . LEU A 1 140 ? 127.966 124.580 130.844 1.00 21.97  ? 140 LEU U CA   1 
ATOM   1002 C C    . LEU A 1 140 ? 127.861 126.098 130.778 1.00 29.41  ? 140 LEU U C    1 
ATOM   1003 O O    . LEU A 1 140 ? 127.428 126.743 131.742 1.00 35.95  ? 140 LEU U O    1 
ATOM   1004 C CB   . LEU A 1 140 ? 129.380 124.158 131.239 1.00 19.85  ? 140 LEU U CB   1 
ATOM   1005 C CG   . LEU A 1 140 ? 129.916 124.685 132.572 1.00 20.20  ? 140 LEU U CG   1 
ATOM   1006 C CD1  . LEU A 1 140 ? 129.123 124.124 133.741 1.00 21.33  ? 140 LEU U CD1  1 
ATOM   1007 C CD2  . LEU A 1 140 ? 131.392 124.363 132.716 1.00 19.46  ? 140 LEU U CD2  1 
ATOM   1008 N N    . PHE A 1 141 ? 128.262 126.686 129.647 1.00 27.72  ? 141 PHE U N    1 
ATOM   1009 C CA   . PHE A 1 141 ? 128.141 128.132 129.476 1.00 24.47  ? 141 PHE U CA   1 
ATOM   1010 C C    . PHE A 1 141 ? 126.684 128.572 129.562 1.00 29.62  ? 141 PHE U C    1 
ATOM   1011 O O    . PHE A 1 141 ? 126.369 129.581 130.206 1.00 32.30  ? 141 PHE U O    1 
ATOM   1012 C CB   . PHE A 1 141 ? 128.751 128.556 128.140 1.00 23.04  ? 141 PHE U CB   1 
ATOM   1013 C CG   . PHE A 1 141 ? 128.770 130.044 127.923 1.00 33.06  ? 141 PHE U CG   1 
ATOM   1014 C CD1  . PHE A 1 141 ? 129.745 130.827 128.517 1.00 26.41  ? 141 PHE U CD1  1 
ATOM   1015 C CD2  . PHE A 1 141 ? 127.813 130.657 127.131 1.00 34.43  ? 141 PHE U CD2  1 
ATOM   1016 C CE1  . PHE A 1 141 ? 129.767 132.195 128.322 1.00 21.72  ? 141 PHE U CE1  1 
ATOM   1017 C CE2  . PHE A 1 141 ? 127.829 132.028 126.938 1.00 30.87  ? 141 PHE U CE2  1 
ATOM   1018 C CZ   . PHE A 1 141 ? 128.808 132.795 127.533 1.00 26.14  ? 141 PHE U CZ   1 
ATOM   1019 N N    . PHE A 1 142 ? 125.780 127.820 128.926 1.00 28.62  ? 142 PHE U N    1 
ATOM   1020 C CA   . PHE A 1 142 ? 124.361 128.161 128.994 1.00 22.89  ? 142 PHE U CA   1 
ATOM   1021 C C    . PHE A 1 142 ? 123.827 128.057 130.420 1.00 30.91  ? 142 PHE U C    1 
ATOM   1022 O O    . PHE A 1 142 ? 123.056 128.914 130.872 1.00 37.28  ? 142 PHE U O    1 
ATOM   1023 C CB   . PHE A 1 142 ? 123.557 127.261 128.058 1.00 26.56  ? 142 PHE U CB   1 
ATOM   1024 C CG   . PHE A 1 142 ? 123.844 127.487 126.599 1.00 28.90  ? 142 PHE U CG   1 
ATOM   1025 C CD1  . PHE A 1 142 ? 124.414 128.672 126.165 1.00 31.62  ? 142 PHE U CD1  1 
ATOM   1026 C CD2  . PHE A 1 142 ? 123.547 126.512 125.664 1.00 30.96  ? 142 PHE U CD2  1 
ATOM   1027 C CE1  . PHE A 1 142 ? 124.678 128.879 124.826 1.00 32.32  ? 142 PHE U CE1  1 
ATOM   1028 C CE2  . PHE A 1 142 ? 123.808 126.711 124.326 1.00 30.30  ? 142 PHE U CE2  1 
ATOM   1029 C CZ   . PHE A 1 142 ? 124.375 127.899 123.905 1.00 28.67  ? 142 PHE U CZ   1 
ATOM   1030 N N    . ASN A 1 143 ? 124.234 127.015 131.152 1.00 33.60  ? 143 ASN U N    1 
ATOM   1031 C CA   . ASN A 1 143 ? 123.785 126.882 132.538 1.00 30.25  ? 143 ASN U CA   1 
ATOM   1032 C C    . ASN A 1 143 ? 124.277 128.040 133.402 1.00 30.75  ? 143 ASN U C    1 
ATOM   1033 O O    . ASN A 1 143 ? 123.519 128.596 134.214 1.00 42.00  ? 143 ASN U O    1 
ATOM   1034 C CB   . ASN A 1 143 ? 124.255 125.546 133.116 1.00 29.51  ? 143 ASN U CB   1 
ATOM   1035 C CG   . ASN A 1 143 ? 123.593 124.358 132.449 1.00 36.49  ? 143 ASN U CG   1 
ATOM   1036 O OD1  . ASN A 1 143 ? 122.510 124.475 131.879 1.00 41.44  ? 143 ASN U OD1  1 
ATOM   1037 N ND2  . ASN A 1 143 ? 124.244 123.204 132.516 1.00 38.04  ? 143 ASN U ND2  1 
ATOM   1038 N N    . LEU A 1 144 ? 125.549 128.419 133.244 1.00 27.71  ? 144 LEU U N    1 
ATOM   1039 C CA   . LEU A 1 144 ? 126.087 129.542 134.005 1.00 29.74  ? 144 LEU U CA   1 
ATOM   1040 C C    . LEU A 1 144 ? 125.382 130.843 133.647 1.00 32.85  ? 144 LEU U C    1 
ATOM   1041 O O    . LEU A 1 144 ? 125.125 131.684 134.519 1.00 39.30  ? 144 LEU U O    1 
ATOM   1042 C CB   . LEU A 1 144 ? 127.594 129.665 133.775 1.00 30.92  ? 144 LEU U CB   1 
ATOM   1043 C CG   . LEU A 1 144 ? 128.457 128.477 134.203 1.00 23.72  ? 144 LEU U CG   1 
ATOM   1044 C CD1  . LEU A 1 144 ? 129.932 128.795 134.008 1.00 23.14  ? 144 LEU U CD1  1 
ATOM   1045 C CD2  . LEU A 1 144 ? 128.174 128.096 135.645 1.00 31.29  ? 144 LEU U CD2  1 
ATOM   1046 N N    . PHE A 1 145 ? 125.062 131.031 132.362 1.00 32.99  ? 145 PHE U N    1 
ATOM   1047 C CA   . PHE A 1 145 ? 124.310 132.211 131.956 1.00 34.43  ? 145 PHE U CA   1 
ATOM   1048 C C    . PHE A 1 145 ? 122.952 132.255 132.640 1.00 33.11  ? 145 PHE U C    1 
ATOM   1049 O O    . PHE A 1 145 ? 122.514 133.316 133.098 1.00 38.42  ? 145 PHE U O    1 
ATOM   1050 C CB   . PHE A 1 145 ? 124.132 132.245 130.438 1.00 35.88  ? 145 PHE U CB   1 
ATOM   1051 C CG   . PHE A 1 145 ? 122.989 133.107 129.984 1.00 41.11  ? 145 PHE U CG   1 
ATOM   1052 C CD1  . PHE A 1 145 ? 123.130 134.483 129.922 1.00 38.89  ? 145 PHE U CD1  1 
ATOM   1053 C CD2  . PHE A 1 145 ? 121.770 132.546 129.636 1.00 36.09  ? 145 PHE U CD2  1 
ATOM   1054 C CE1  . PHE A 1 145 ? 122.083 135.284 129.512 1.00 36.63  ? 145 PHE U CE1  1 
ATOM   1055 C CE2  . PHE A 1 145 ? 120.716 133.346 129.231 1.00 36.25  ? 145 PHE U CE2  1 
ATOM   1056 C CZ   . PHE A 1 145 ? 120.874 134.714 129.165 1.00 37.49  ? 145 PHE U CZ   1 
ATOM   1057 N N    . LEU A 1 146 ? 122.259 131.116 132.697 1.00 33.67  ? 146 LEU U N    1 
ATOM   1058 C CA   . LEU A 1 146 ? 120.951 131.089 133.345 1.00 35.02  ? 146 LEU U CA   1 
ATOM   1059 C C    . LEU A 1 146 ? 121.060 131.432 134.825 1.00 37.38  ? 146 LEU U C    1 
ATOM   1060 O O    . LEU A 1 146 ? 120.236 132.187 135.361 1.00 43.90  ? 146 LEU U O    1 
ATOM   1061 C CB   . LEU A 1 146 ? 120.296 129.720 133.162 1.00 36.60  ? 146 LEU U CB   1 
ATOM   1062 C CG   . LEU A 1 146 ? 118.935 129.542 133.838 1.00 38.39  ? 146 LEU U CG   1 
ATOM   1063 C CD1  . LEU A 1 146 ? 117.944 130.599 133.378 1.00 35.33  ? 146 LEU U CD1  1 
ATOM   1064 C CD2  . LEU A 1 146 ? 118.385 128.151 133.581 1.00 37.37  ? 146 LEU U CD2  1 
ATOM   1065 N N    . GLU A 1 147 ? 122.072 130.885 135.507 1.00 39.33  ? 147 GLU U N    1 
ATOM   1066 C CA   . GLU A 1 147 ? 122.253 131.214 136.920 1.00 36.79  ? 147 GLU U CA   1 
ATOM   1067 C C    . GLU A 1 147 ? 122.515 132.705 137.119 1.00 42.26  ? 147 GLU U C    1 
ATOM   1068 O O    . GLU A 1 147 ? 121.926 133.340 138.008 1.00 48.99  ? 147 GLU U O    1 
ATOM   1069 C CB   . GLU A 1 147 ? 123.389 130.380 137.513 1.00 41.01  ? 147 GLU U CB   1 
ATOM   1070 C CG   . GLU A 1 147 ? 123.921 130.911 138.829 1.00 47.34  ? 147 GLU U CG   1 
ATOM   1071 C CD   . GLU A 1 147 ? 125.160 130.174 139.299 1.00 58.02  ? 147 GLU U CD   1 
ATOM   1072 O OE1  . GLU A 1 147 ? 125.464 129.101 138.740 1.00 59.08  ? 147 GLU U OE1  1 
ATOM   1073 O OE2  . GLU A 1 147 ? 125.826 130.673 140.230 1.00 55.23  ? 147 GLU U OE2  1 
ATOM   1074 N N    . ARG A 1 148 ? 123.385 133.284 136.287 1.00 44.55  ? 148 ARG U N    1 
ATOM   1075 C CA   . ARG A 1 148 ? 123.676 134.713 136.401 1.00 41.65  ? 148 ARG U CA   1 
ATOM   1076 C C    . ARG A 1 148 ? 122.436 135.554 136.131 1.00 40.27  ? 148 ARG U C    1 
ATOM   1077 O O    . ARG A 1 148 ? 122.206 136.569 136.798 1.00 39.39  ? 148 ARG U O    1 
ATOM   1078 C CB   . ARG A 1 148 ? 124.808 135.099 135.446 1.00 36.82  ? 148 ARG U CB   1 
ATOM   1079 C CG   . ARG A 1 148 ? 126.175 134.552 135.839 1.00 32.22  ? 148 ARG U CG   1 
ATOM   1080 C CD   . ARG A 1 148 ? 126.792 135.357 136.970 1.00 34.80  ? 148 ARG U CD   1 
ATOM   1081 N NE   . ARG A 1 148 ? 126.347 134.888 138.276 1.00 42.71  ? 148 ARG U NE   1 
ATOM   1082 C CZ   . ARG A 1 148 ? 126.595 135.508 139.422 1.00 40.27  ? 148 ARG U CZ   1 
ATOM   1083 N NH1  . ARG A 1 148 ? 127.267 136.647 139.460 1.00 40.05  ? 148 ARG U NH1  1 
ATOM   1084 N NH2  . ARG A 1 148 ? 126.147 134.978 140.556 1.00 39.27  ? 148 ARG U NH2  1 
ATOM   1085 N N    . LEU A 1 149 ? 121.633 135.155 135.139 1.00 46.95  ? 149 LEU U N    1 
ATOM   1086 C CA   . LEU A 1 149 ? 120.411 135.888 134.834 1.00 45.22  ? 149 LEU U CA   1 
ATOM   1087 C C    . LEU A 1 149 ? 119.435 135.851 135.999 1.00 42.18  ? 149 LEU U C    1 
ATOM   1088 O O    . LEU A 1 149 ? 118.821 136.871 136.334 1.00 44.37  ? 149 LEU U O    1 
ATOM   1089 C CB   . LEU A 1 149 ? 119.761 135.315 133.571 1.00 42.33  ? 149 LEU U CB   1 
ATOM   1090 C CG   . LEU A 1 149 ? 118.416 135.926 133.178 1.00 40.07  ? 149 LEU U CG   1 
ATOM   1091 C CD1  . LEU A 1 149 ? 118.584 137.380 132.776 1.00 40.43  ? 149 LEU U CD1  1 
ATOM   1092 C CD2  . LEU A 1 149 ? 117.777 135.128 132.054 1.00 41.70  ? 149 LEU U CD2  1 
ATOM   1093 N N    . ILE A 1 150 ? 119.270 134.685 136.629 1.00 41.54  ? 150 ILE U N    1 
ATOM   1094 C CA   . ILE A 1 150 ? 118.376 134.603 137.782 1.00 40.09  ? 150 ILE U CA   1 
ATOM   1095 C C    . ILE A 1 150 ? 118.873 135.502 138.908 1.00 42.60  ? 150 ILE U C    1 
ATOM   1096 O O    . ILE A 1 150 ? 118.089 136.223 139.546 1.00 45.49  ? 150 ILE U O    1 
ATOM   1097 C CB   . ILE A 1 150 ? 118.225 133.142 138.246 1.00 39.46  ? 150 ILE U CB   1 
ATOM   1098 C CG1  . ILE A 1 150 ? 117.497 132.317 137.185 1.00 39.64  ? 150 ILE U CG1  1 
ATOM   1099 C CG2  . ILE A 1 150 ? 117.482 133.075 139.572 1.00 41.05  ? 150 ILE U CG2  1 
ATOM   1100 C CD1  . ILE A 1 150 ? 117.334 130.864 137.556 1.00 40.46  ? 150 ILE U CD1  1 
ATOM   1101 N N    . THR A 1 151 ? 120.187 135.487 139.164 1.00 49.26  ? 151 THR U N    1 
ATOM   1102 C CA   . THR A 1 151 ? 120.740 136.326 140.224 1.00 47.16  ? 151 THR U CA   1 
ATOM   1103 C C    . THR A 1 151 ? 120.506 137.808 139.940 1.00 49.95  ? 151 THR U C    1 
ATOM   1104 O O    . THR A 1 151 ? 120.086 138.565 140.826 1.00 53.23  ? 151 THR U O    1 
ATOM   1105 C CB   . THR A 1 151 ? 122.231 136.038 140.398 1.00 46.21  ? 151 THR U CB   1 
ATOM   1106 O OG1  . THR A 1 151 ? 122.413 134.676 140.802 1.00 53.24  ? 151 THR U OG1  1 
ATOM   1107 C CG2  . THR A 1 151 ? 122.834 136.958 141.445 1.00 44.08  ? 151 THR U CG2  1 
ATOM   1108 N N    . ILE A 1 152 ? 120.768 138.242 138.705 1.00 53.37  ? 152 ILE U N    1 
ATOM   1109 C CA   . ILE A 1 152 ? 120.589 139.654 138.385 1.00 47.55  ? 152 ILE U CA   1 
ATOM   1110 C C    . ILE A 1 152 ? 119.114 140.036 138.441 1.00 51.29  ? 152 ILE U C    1 
ATOM   1111 O O    . ILE A 1 152 ? 118.775 141.149 138.854 1.00 55.21  ? 152 ILE U O    1 
ATOM   1112 C CB   . ILE A 1 152 ? 121.232 140.000 137.026 1.00 48.94  ? 152 ILE U CB   1 
ATOM   1113 C CG1  . ILE A 1 152 ? 121.477 141.506 136.922 1.00 49.42  ? 152 ILE U CG1  1 
ATOM   1114 C CG2  . ILE A 1 152 ? 120.383 139.525 135.857 1.00 45.52  ? 152 ILE U CG2  1 
ATOM   1115 C CD1  . ILE A 1 152 ? 122.458 142.034 137.943 1.00 53.27  ? 152 ILE U CD1  1 
ATOM   1116 N N    . ILE A 1 153 ? 118.217 139.128 138.050 1.00 54.60  ? 153 ILE U N    1 
ATOM   1117 C CA   . ILE A 1 153 ? 116.787 139.424 138.114 1.00 51.32  ? 153 ILE U CA   1 
ATOM   1118 C C    . ILE A 1 153 ? 116.366 139.636 139.559 1.00 52.81  ? 153 ILE U C    1 
ATOM   1119 O O    . ILE A 1 153 ? 115.626 140.581 139.877 1.00 56.28  ? 153 ILE U O    1 
ATOM   1120 C CB   . ILE A 1 153 ? 115.977 138.302 137.439 1.00 49.38  ? 153 ILE U CB   1 
ATOM   1121 C CG1  . ILE A 1 153 ? 115.877 138.553 135.934 1.00 52.56  ? 153 ILE U CG1  1 
ATOM   1122 C CG2  . ILE A 1 153 ? 114.586 138.196 138.051 1.00 48.43  ? 153 ILE U CG2  1 
ATOM   1123 C CD1  . ILE A 1 153 ? 114.925 137.623 135.222 1.00 52.51  ? 153 ILE U CD1  1 
ATOM   1124 N N    . ALA A 1 154 ? 116.835 138.767 140.460 1.00 62.62  ? 154 ALA U N    1 
ATOM   1125 C CA   . ALA A 1 154 ? 116.528 138.941 141.875 1.00 61.53  ? 154 ALA U CA   1 
ATOM   1126 C C    . ALA A 1 154 ? 117.081 140.264 142.399 1.00 59.55  ? 154 ALA U C    1 
ATOM   1127 O O    . ALA A 1 154 ? 116.418 140.954 143.183 1.00 64.01  ? 154 ALA U O    1 
ATOM   1128 C CB   . ALA A 1 154 ? 117.084 137.769 142.683 1.00 60.59  ? 154 ALA U CB   1 
ATOM   1129 N N    . TYR A 1 155 ? 118.299 140.627 141.982 1.00 68.64  ? 155 TYR U N    1 
ATOM   1130 C CA   . TYR A 1 155 ? 118.882 141.886 142.442 1.00 71.01  ? 155 TYR U CA   1 
ATOM   1131 C C    . TYR A 1 155 ? 118.056 143.086 141.985 1.00 71.48  ? 155 TYR U C    1 
ATOM   1132 O O    . TYR A 1 155 ? 117.790 144.003 142.773 1.00 70.91  ? 155 TYR U O    1 
ATOM   1133 C CB   . TYR A 1 155 ? 120.324 142.011 141.953 1.00 70.67  ? 155 TYR U CB   1 
ATOM   1134 C CG   . TYR A 1 155 ? 121.085 143.155 142.580 1.00 72.93  ? 155 TYR U CG   1 
ATOM   1135 C CD1  . TYR A 1 155 ? 121.745 142.996 143.791 1.00 74.35  ? 155 TYR U CD1  1 
ATOM   1136 C CD2  . TYR A 1 155 ? 121.145 144.397 141.961 1.00 73.30  ? 155 TYR U CD2  1 
ATOM   1137 C CE1  . TYR A 1 155 ? 122.442 144.043 144.370 1.00 75.80  ? 155 TYR U CE1  1 
ATOM   1138 C CE2  . TYR A 1 155 ? 121.840 145.447 142.531 1.00 73.79  ? 155 TYR U CE2  1 
ATOM   1139 C CZ   . TYR A 1 155 ? 122.488 145.264 143.735 1.00 76.41  ? 155 TYR U CZ   1 
ATOM   1140 O OH   . TYR A 1 155 ? 123.179 146.307 144.306 1.00 75.59  ? 155 TYR U OH   1 
ATOM   1141 N N    . ILE A 1 156 ? 117.640 143.095 140.714 1.00 69.54  ? 156 ILE U N    1 
ATOM   1142 C CA   . ILE A 1 156 ? 116.818 144.195 140.211 1.00 68.33  ? 156 ILE U CA   1 
ATOM   1143 C C    . ILE A 1 156 ? 115.490 144.254 140.949 1.00 70.12  ? 156 ILE U C    1 
ATOM   1144 O O    . ILE A 1 156 ? 115.000 145.337 141.289 1.00 69.57  ? 156 ILE U O    1 
ATOM   1145 C CB   . ILE A 1 156 ? 116.615 144.096 138.686 1.00 68.06  ? 156 ILE U CB   1 
ATOM   1146 C CG1  . ILE A 1 156 ? 117.946 143.872 137.971 1.00 68.78  ? 156 ILE U CG1  1 
ATOM   1147 C CG2  . ILE A 1 156 ? 115.928 145.346 138.157 1.00 68.48  ? 156 ILE U CG2  1 
ATOM   1148 C CD1  . ILE A 1 156 ? 117.831 143.854 136.462 1.00 68.71  ? 156 ILE U CD1  1 
ATOM   1149 N N    . MET A 1 157 ? 114.867 143.097 141.186 1.00 81.92  ? 157 MET U N    1 
ATOM   1150 C CA   . MET A 1 157 ? 113.587 143.090 141.887 1.00 79.85  ? 157 MET U CA   1 
ATOM   1151 C C    . MET A 1 157 ? 113.731 143.650 143.296 1.00 80.93  ? 157 MET U C    1 
ATOM   1152 O O    . MET A 1 157 ? 112.904 144.461 143.739 1.00 81.75  ? 157 MET U O    1 
ATOM   1153 C CB   . MET A 1 157 ? 113.010 141.675 141.927 1.00 77.36  ? 157 MET U CB   1 
ATOM   1154 C CG   . MET A 1 157 ? 111.946 141.410 140.875 1.00 81.15  ? 157 MET U CG   1 
ATOM   1155 S SD   . MET A 1 157 ? 111.517 139.666 140.728 1.00 90.10  ? 157 MET U SD   1 
ATOM   1156 C CE   . MET A 1 157 ? 111.629 139.143 142.438 1.00 83.38  ? 157 MET U CE   1 
ATOM   1157 N N    . LYS A 1 158 ? 114.779 143.237 144.015 1.00 89.02  ? 158 LYS U N    1 
ATOM   1158 C CA   . LYS A 1 158 ? 114.998 143.753 145.363 1.00 88.73  ? 158 LYS U CA   1 
ATOM   1159 C C    . LYS A 1 158 ? 115.245 145.257 145.345 1.00 89.81  ? 158 LYS U C    1 
ATOM   1160 O O    . LYS A 1 158 ? 114.709 145.992 146.188 1.00 91.36  ? 158 LYS U O    1 
ATOM   1161 C CB   . LYS A 1 158 ? 116.165 143.024 146.025 1.00 88.21  ? 158 LYS U CB   1 
ATOM   1162 C CG   . LYS A 1 158 ? 116.521 143.555 147.406 1.00 89.50  ? 158 LYS U CG   1 
ATOM   1163 C CD   . LYS A 1 158 ? 117.759 142.876 147.963 1.00 90.39  ? 158 LYS U CD   1 
ATOM   1164 C CE   . LYS A 1 158 ? 118.143 143.453 149.316 1.00 87.83  ? 158 LYS U CE   1 
ATOM   1165 N NZ   . LYS A 1 158 ? 117.047 143.298 150.312 1.00 88.09  ? 158 LYS U NZ   1 
ATOM   1166 N N    . SER A 1 159 ? 116.053 145.734 144.397 1.00 91.92  ? 159 SER U N    1 
ATOM   1167 C CA   . SER A 1 159 ? 116.335 147.166 144.324 1.00 92.51  ? 159 SER U CA   1 
ATOM   1168 C C    . SER A 1 159 ? 115.074 147.959 144.013 1.00 93.13  ? 159 SER U C    1 
ATOM   1169 O O    . SER A 1 159 ? 114.839 149.026 144.593 1.00 93.30  ? 159 SER U O    1 
ATOM   1170 C CB   . SER A 1 159 ? 117.415 147.439 143.279 1.00 93.57  ? 159 SER U CB   1 
ATOM   1171 O OG   . SER A 1 159 ? 117.709 148.821 143.197 1.00 93.01  ? 159 SER U OG   1 
ATOM   1172 N N    . CYS A 1 160 ? 114.245 147.450 143.097 1.00 97.35  ? 160 CYS U N    1 
ATOM   1173 C CA   . CYS A 1 160 ? 113.004 148.131 142.751 1.00 98.59  ? 160 CYS U CA   1 
ATOM   1174 C C    . CYS A 1 160 ? 112.058 148.183 143.944 1.00 97.68  ? 160 CYS U C    1 
ATOM   1175 O O    . CYS A 1 160 ? 111.426 149.215 144.199 1.00 98.29  ? 160 CYS U O    1 
ATOM   1176 C CB   . CYS A 1 160 ? 112.335 147.436 141.564 1.00 98.37  ? 160 CYS U CB   1 
ATOM   1177 S SG   . CYS A 1 160 ? 110.812 148.229 140.997 1.00 97.38  ? 160 CYS U SG   1 
ATOM   1178 N N    . HIS A 1 161 ? 111.943 147.074 144.685 1.00 101.32 ? 161 HIS U N    1 
ATOM   1179 C CA   . HIS A 1 161 ? 111.091 147.076 145.871 1.00 103.29 ? 161 HIS U CA   1 
ATOM   1180 C C    . HIS A 1 161 ? 111.601 148.066 146.911 1.00 103.57 ? 161 HIS U C    1 
ATOM   1181 O O    . HIS A 1 161 ? 110.812 148.801 147.520 1.00 103.11 ? 161 HIS U O    1 
ATOM   1182 C CB   . HIS A 1 161 ? 111.009 145.670 146.464 1.00 103.01 ? 161 HIS U CB   1 
ATOM   1183 C CG   . HIS A 1 161 ? 110.181 145.588 147.709 1.00 103.32 ? 161 HIS U CG   1 
ATOM   1184 N ND1  . HIS A 1 161 ? 110.686 145.878 148.961 1.00 102.84 ? 161 HIS U ND1  1 
ATOM   1185 C CD2  . HIS A 1 161 ? 108.883 145.253 147.898 1.00 103.01 ? 161 HIS U CD2  1 
ATOM   1186 C CE1  . HIS A 1 161 ? 109.735 145.723 149.861 1.00 103.25 ? 161 HIS U CE1  1 
ATOM   1187 N NE2  . HIS A 1 161 ? 108.632 145.345 149.244 1.00 104.81 ? 161 HIS U NE2  1 
ATOM   1188 N N    . GLN A 1 162 ? 112.920 148.106 147.124 1.00 107.37 ? 162 GLN U N    1 
ATOM   1189 C CA   . GLN A 1 162 ? 113.479 149.030 148.106 1.00 107.30 ? 162 GLN U CA   1 
ATOM   1190 C C    . GLN A 1 162 ? 113.232 150.475 147.696 1.00 107.71 ? 162 GLN U C    1 
ATOM   1191 O O    . GLN A 1 162 ? 112.913 151.322 148.540 1.00 107.41 ? 162 GLN U O    1 
ATOM   1192 C CB   . GLN A 1 162 ? 114.973 148.768 148.288 1.00 107.01 ? 162 GLN U CB   1 
ATOM   1193 C CG   . GLN A 1 162 ? 115.538 149.305 149.595 1.00 106.96 ? 162 GLN U CG   1 
ATOM   1194 C CD   . GLN A 1 162 ? 115.966 150.757 149.498 1.00 108.30 ? 162 GLN U CD   1 
ATOM   1195 O OE1  . GLN A 1 162 ? 116.179 151.281 148.406 1.00 109.15 ? 162 GLN U OE1  1 
ATOM   1196 N NE2  . GLN A 1 162 ? 116.087 151.414 150.645 1.00 107.26 ? 162 GLN U NE2  1 
ATOM   1197 N N    . ALA A 1 188 ? 119.062 137.322 148.359 1.00 91.13  ? 188 ALA U N    1 
ATOM   1198 C CA   . ALA A 1 188 ? 118.755 136.572 149.573 1.00 94.01  ? 188 ALA U CA   1 
ATOM   1199 C C    . ALA A 1 188 ? 117.434 135.825 149.432 1.00 96.22  ? 188 ALA U C    1 
ATOM   1200 O O    . ALA A 1 188 ? 117.332 134.858 148.676 1.00 94.14  ? 188 ALA U O    1 
ATOM   1201 C CB   . ALA A 1 188 ? 118.713 137.504 150.776 1.00 91.82  ? 188 ALA U CB   1 
ATOM   1202 N N    . GLY A 1 189 ? 116.419 136.280 150.162 1.00 95.47  ? 189 GLY U N    1 
ATOM   1203 C CA   . GLY A 1 189 ? 115.119 135.638 150.134 1.00 93.28  ? 189 GLY U CA   1 
ATOM   1204 C C    . GLY A 1 189 ? 114.162 136.259 149.142 1.00 92.89  ? 189 GLY U C    1 
ATOM   1205 O O    . GLY A 1 189 ? 112.947 136.057 149.231 1.00 90.95  ? 189 GLY U O    1 
ATOM   1206 N N    . TRP A 1 190 ? 114.696 137.020 148.187 1.00 90.26  ? 190 TRP U N    1 
ATOM   1207 C CA   . TRP A 1 190 ? 113.890 137.712 147.189 1.00 88.11  ? 190 TRP U CA   1 
ATOM   1208 C C    . TRP A 1 190 ? 113.926 137.026 145.825 1.00 86.77  ? 190 TRP U C    1 
ATOM   1209 O O    . TRP A 1 190 ? 113.647 137.671 144.811 1.00 89.42  ? 190 TRP U O    1 
ATOM   1210 C CB   . TRP A 1 190 ? 114.343 139.167 147.060 1.00 88.65  ? 190 TRP U CB   1 
ATOM   1211 C CG   . TRP A 1 190 ? 114.239 139.947 148.334 1.00 90.14  ? 190 TRP U CG   1 
ATOM   1212 C CD1  . TRP A 1 190 ? 115.123 139.943 149.373 1.00 89.80  ? 190 TRP U CD1  1 
ATOM   1213 C CD2  . TRP A 1 190 ? 113.191 140.850 148.703 1.00 91.15  ? 190 TRP U CD2  1 
ATOM   1214 N NE1  . TRP A 1 190 ? 114.687 140.787 150.366 1.00 89.97  ? 190 TRP U NE1  1 
ATOM   1215 C CE2  . TRP A 1 190 ? 113.503 141.355 149.980 1.00 91.05  ? 190 TRP U CE2  1 
ATOM   1216 C CE3  . TRP A 1 190 ? 112.014 141.279 148.077 1.00 90.24  ? 190 TRP U CE3  1 
ATOM   1217 C CZ2  . TRP A 1 190 ? 112.687 142.268 150.642 1.00 90.40  ? 190 TRP U CZ2  1 
ATOM   1218 C CZ3  . TRP A 1 190 ? 111.205 142.184 148.738 1.00 89.66  ? 190 TRP U CZ3  1 
ATOM   1219 C CH2  . TRP A 1 190 ? 111.544 142.670 150.007 1.00 90.59  ? 190 TRP U CH2  1 
ATOM   1220 N N    . LYS A 1 191 ? 114.275 135.744 145.784 1.00 76.21  ? 191 LYS U N    1 
ATOM   1221 C CA   . LYS A 1 191 ? 114.338 135.039 144.513 1.00 78.68  ? 191 LYS U CA   1 
ATOM   1222 C C    . LYS A 1 191 ? 112.944 134.933 143.899 1.00 77.02  ? 191 LYS U C    1 
ATOM   1223 O O    . LYS A 1 191 ? 111.974 134.638 144.605 1.00 77.94  ? 191 LYS U O    1 
ATOM   1224 C CB   . LYS A 1 191 ? 114.935 133.645 144.700 1.00 79.37  ? 191 LYS U CB   1 
ATOM   1225 C CG   . LYS A 1 191 ? 116.428 133.644 144.975 1.00 81.48  ? 191 LYS U CG   1 
ATOM   1226 C CD   . LYS A 1 191 ? 116.977 132.231 145.065 1.00 81.02  ? 191 LYS U CD   1 
ATOM   1227 C CE   . LYS A 1 191 ? 118.480 132.236 145.306 1.00 79.36  ? 191 LYS U CE   1 
ATOM   1228 N NZ   . LYS A 1 191 ? 119.028 130.859 145.444 1.00 79.78  ? 191 LYS U NZ   1 
ATOM   1229 N N    . PRO A 1 192 ? 112.809 135.163 142.596 1.00 66.02  ? 192 PRO U N    1 
ATOM   1230 C CA   . PRO A 1 192 ? 111.486 135.095 141.970 1.00 66.83  ? 192 PRO U CA   1 
ATOM   1231 C C    . PRO A 1 192 ? 110.999 133.661 141.837 1.00 66.12  ? 192 PRO U C    1 
ATOM   1232 O O    . PRO A 1 192 ? 111.766 132.699 141.921 1.00 66.37  ? 192 PRO U O    1 
ATOM   1233 C CB   . PRO A 1 192 ? 111.716 135.734 140.598 1.00 66.48  ? 192 PRO U CB   1 
ATOM   1234 C CG   . PRO A 1 192 ? 113.149 135.446 140.302 1.00 63.51  ? 192 PRO U CG   1 
ATOM   1235 C CD   . PRO A 1 192 ? 113.863 135.508 141.628 1.00 63.09  ? 192 PRO U CD   1 
ATOM   1236 N N    . SER A 1 193 ? 109.690 133.529 141.633 1.00 56.10  ? 193 SER U N    1 
ATOM   1237 C CA   . SER A 1 193 ? 109.095 132.224 141.407 1.00 52.27  ? 193 SER U CA   1 
ATOM   1238 C C    . SER A 1 193 ? 109.374 131.747 139.984 1.00 54.32  ? 193 SER U C    1 
ATOM   1239 O O    . SER A 1 193 ? 109.865 132.490 139.131 1.00 58.82  ? 193 SER U O    1 
ATOM   1240 C CB   . SER A 1 193 ? 107.591 132.272 141.668 1.00 54.59  ? 193 SER U CB   1 
ATOM   1241 O OG   . SER A 1 193 ? 106.945 133.175 140.789 1.00 57.37  ? 193 SER U OG   1 
ATOM   1242 N N    . VAL A 1 194 ? 109.045 130.479 139.729 1.00 46.31  ? 194 VAL U N    1 
ATOM   1243 C CA   . VAL A 1 194 ? 109.275 129.903 138.409 1.00 47.30  ? 194 VAL U CA   1 
ATOM   1244 C C    . VAL A 1 194 ? 108.359 130.542 137.374 1.00 50.58  ? 194 VAL U C    1 
ATOM   1245 O O    . VAL A 1 194 ? 108.750 130.741 136.216 1.00 53.92  ? 194 VAL U O    1 
ATOM   1246 C CB   . VAL A 1 194 ? 109.091 128.373 138.467 1.00 48.24  ? 194 VAL U CB   1 
ATOM   1247 C CG1  . VAL A 1 194 ? 109.416 127.740 137.127 1.00 48.06  ? 194 VAL U CG1  1 
ATOM   1248 C CG2  . VAL A 1 194 ? 109.955 127.778 139.567 1.00 48.75  ? 194 VAL U CG2  1 
ATOM   1249 N N    . TYR A 1 195 ? 107.124 130.865 137.769 1.00 51.32  ? 195 TYR U N    1 
ATOM   1250 C CA   . TYR A 1 195 ? 106.161 131.453 136.841 1.00 51.84  ? 195 TYR U CA   1 
ATOM   1251 C C    . TYR A 1 195 ? 106.648 132.800 136.314 1.00 57.73  ? 195 TYR U C    1 
ATOM   1252 O O    . TYR A 1 195 ? 106.575 133.079 135.109 1.00 60.18  ? 195 TYR U O    1 
ATOM   1253 C CB   . TYR A 1 195 ? 104.807 131.591 137.537 1.00 51.81  ? 195 TYR U CB   1 
ATOM   1254 C CG   . TYR A 1 195 ? 103.669 132.033 136.644 1.00 59.12  ? 195 TYR U CG   1 
ATOM   1255 C CD1  . TYR A 1 195 ? 103.194 131.212 135.631 1.00 58.77  ? 195 TYR U CD1  1 
ATOM   1256 C CD2  . TYR A 1 195 ? 103.054 133.264 136.831 1.00 57.98  ? 195 TYR U CD2  1 
ATOM   1257 C CE1  . TYR A 1 195 ? 102.150 131.608 134.818 1.00 61.24  ? 195 TYR U CE1  1 
ATOM   1258 C CE2  . TYR A 1 195 ? 102.007 133.670 136.023 1.00 54.06  ? 195 TYR U CE2  1 
ATOM   1259 C CZ   . TYR A 1 195 ? 101.560 132.839 135.019 1.00 59.76  ? 195 TYR U CZ   1 
ATOM   1260 O OH   . TYR A 1 195 ? 100.521 133.238 134.212 1.00 62.48  ? 195 TYR U OH   1 
ATOM   1261 N N    . TYR A 1 196 ? 107.155 133.651 137.211 1.00 55.33  ? 196 TYR U N    1 
ATOM   1262 C CA   . TYR A 1 196 ? 107.628 134.969 136.799 1.00 53.68  ? 196 TYR U CA   1 
ATOM   1263 C C    . TYR A 1 196 ? 108.864 134.858 135.916 1.00 53.91  ? 196 TYR U C    1 
ATOM   1264 O O    . TYR A 1 196 ? 109.013 135.614 134.951 1.00 60.26  ? 196 TYR U O    1 
ATOM   1265 C CB   . TYR A 1 196 ? 107.917 135.829 138.028 1.00 54.27  ? 196 TYR U CB   1 
ATOM   1266 C CG   . TYR A 1 196 ? 106.676 136.243 138.787 1.00 61.24  ? 196 TYR U CG   1 
ATOM   1267 C CD1  . TYR A 1 196 ? 105.438 136.285 138.161 1.00 59.05  ? 196 TYR U CD1  1 
ATOM   1268 C CD2  . TYR A 1 196 ? 106.743 136.590 140.129 1.00 61.33  ? 196 TYR U CD2  1 
ATOM   1269 C CE1  . TYR A 1 196 ? 104.302 136.659 138.851 1.00 59.05  ? 196 TYR U CE1  1 
ATOM   1270 C CE2  . TYR A 1 196 ? 105.613 136.967 140.829 1.00 60.07  ? 196 TYR U CE2  1 
ATOM   1271 C CZ   . TYR A 1 196 ? 104.394 136.999 140.182 1.00 62.05  ? 196 TYR U CZ   1 
ATOM   1272 O OH   . TYR A 1 196 ? 103.265 137.374 140.871 1.00 61.90  ? 196 TYR U OH   1 
ATOM   1273 N N    . VAL A 1 197 ? 109.765 133.924 136.235 1.00 44.66  ? 197 VAL U N    1 
ATOM   1274 C CA   . VAL A 1 197 ? 110.937 133.704 135.394 1.00 42.90  ? 197 VAL U CA   1 
ATOM   1275 C C    . VAL A 1 197 ? 110.509 133.250 134.007 1.00 44.77  ? 197 VAL U C    1 
ATOM   1276 O O    . VAL A 1 197 ? 111.075 133.684 132.995 1.00 48.75  ? 197 VAL U O    1 
ATOM   1277 C CB   . VAL A 1 197 ? 111.896 132.697 136.056 1.00 44.00  ? 197 VAL U CB   1 
ATOM   1278 C CG1  . VAL A 1 197 ? 113.056 132.379 135.126 1.00 44.16  ? 197 VAL U CG1  1 
ATOM   1279 C CG2  . VAL A 1 197 ? 112.417 133.254 137.366 1.00 47.83  ? 197 VAL U CG2  1 
ATOM   1280 N N    . MET A 1 198 ? 109.506 132.371 133.933 1.00 49.12  ? 198 MET U N    1 
ATOM   1281 C CA   . MET A 1 198 ? 109.011 131.926 132.635 1.00 46.24  ? 198 MET U CA   1 
ATOM   1282 C C    . MET A 1 198 ? 108.423 133.086 131.844 1.00 48.90  ? 198 MET U C    1 
ATOM   1283 O O    . MET A 1 198 ? 108.670 133.213 130.639 1.00 55.04  ? 198 MET U O    1 
ATOM   1284 C CB   . MET A 1 198 ? 107.972 130.822 132.822 1.00 50.56  ? 198 MET U CB   1 
ATOM   1285 C CG   . MET A 1 198 ? 107.804 129.924 131.609 1.00 54.79  ? 198 MET U CG   1 
ATOM   1286 S SD   . MET A 1 198 ? 106.117 129.329 131.397 1.00 68.66  ? 198 MET U SD   1 
ATOM   1287 C CE   . MET A 1 198 ? 105.195 130.850 131.595 1.00 53.05  ? 198 MET U CE   1 
ATOM   1288 N N    . LEU A 1 199 ? 107.637 133.943 132.503 1.00 44.14  ? 199 LEU U N    1 
ATOM   1289 C CA   . LEU A 1 199 ? 107.061 135.094 131.811 1.00 45.41  ? 199 LEU U CA   1 
ATOM   1290 C C    . LEU A 1 199 ? 108.145 136.039 131.303 1.00 47.09  ? 199 LEU U C    1 
ATOM   1291 O O    . LEU A 1 199 ? 108.074 136.534 130.168 1.00 49.54  ? 199 LEU U O    1 
ATOM   1292 C CB   . LEU A 1 199 ? 106.091 135.835 132.732 1.00 41.74  ? 199 LEU U CB   1 
ATOM   1293 C CG   . LEU A 1 199 ? 104.843 135.068 133.180 1.00 46.96  ? 199 LEU U CG   1 
ATOM   1294 C CD1  . LEU A 1 199 ? 103.904 135.981 133.952 1.00 48.61  ? 199 LEU U CD1  1 
ATOM   1295 C CD2  . LEU A 1 199 ? 104.134 134.454 131.986 1.00 45.77  ? 199 LEU U CD2  1 
ATOM   1296 N N    . ILE A 1 200 ? 109.161 136.301 132.130 1.00 44.70  ? 200 ILE U N    1 
ATOM   1297 C CA   . ILE A 1 200 ? 110.239 137.200 131.732 1.00 43.51  ? 200 ILE U CA   1 
ATOM   1298 C C    . ILE A 1 200 ? 111.035 136.607 130.576 1.00 45.22  ? 200 ILE U C    1 
ATOM   1299 O O    . ILE A 1 200 ? 111.417 137.318 129.640 1.00 47.74  ? 200 ILE U O    1 
ATOM   1300 C CB   . ILE A 1 200 ? 111.139 137.518 132.941 1.00 39.17  ? 200 ILE U CB   1 
ATOM   1301 C CG1  . ILE A 1 200 ? 110.404 138.425 133.927 1.00 44.52  ? 200 ILE U CG1  1 
ATOM   1302 C CG2  . ILE A 1 200 ? 112.441 138.168 132.495 1.00 38.11  ? 200 ILE U CG2  1 
ATOM   1303 C CD1  . ILE A 1 200 ? 111.201 138.747 135.168 1.00 42.40  ? 200 ILE U CD1  1 
ATOM   1304 N N    . LEU A 1 201 ? 111.298 135.300 130.623 1.00 39.28  ? 201 LEU U N    1 
ATOM   1305 C CA   . LEU A 1 201 ? 112.008 134.649 129.525 1.00 34.64  ? 201 LEU U CA   1 
ATOM   1306 C C    . LEU A 1 201 ? 111.195 134.691 128.239 1.00 41.16  ? 201 LEU U C    1 
ATOM   1307 O O    . LEU A 1 201 ? 111.752 134.890 127.156 1.00 44.92  ? 201 LEU U O    1 
ATOM   1308 C CB   . LEU A 1 201 ? 112.348 133.207 129.903 1.00 36.31  ? 201 LEU U CB   1 
ATOM   1309 C CG   . LEU A 1 201 ? 113.542 133.030 130.844 1.00 36.79  ? 201 LEU U CG   1 
ATOM   1310 C CD1  . LEU A 1 201 ? 113.656 131.587 131.303 1.00 38.71  ? 201 LEU U CD1  1 
ATOM   1311 C CD2  . LEU A 1 201 ? 114.828 133.487 130.173 1.00 37.55  ? 201 LEU U CD2  1 
ATOM   1312 N N    . CYS A 1 202 ? 109.876 134.508 128.336 1.00 45.99  ? 202 CYS U N    1 
ATOM   1313 C CA   . CYS A 1 202 ? 109.029 134.602 127.152 1.00 41.79  ? 202 CYS U CA   1 
ATOM   1314 C C    . CYS A 1 202 ? 109.081 136.004 126.556 1.00 43.46  ? 202 CYS U C    1 
ATOM   1315 O O    . CYS A 1 202 ? 109.207 136.175 125.335 1.00 44.18  ? 202 CYS U O    1 
ATOM   1316 C CB   . CYS A 1 202 ? 107.589 134.221 127.501 1.00 37.76  ? 202 CYS U CB   1 
ATOM   1317 S SG   . CYS A 1 202 ? 107.315 132.460 127.782 1.00 58.80  ? 202 CYS U SG   1 
ATOM   1318 N N    . THR A 1 203 ? 108.982 137.027 127.413 1.00 39.83  ? 203 THR U N    1 
ATOM   1319 C CA   . THR A 1 203 ? 109.046 138.404 126.928 1.00 36.31  ? 203 THR U CA   1 
ATOM   1320 C C    . THR A 1 203 ? 110.393 138.703 126.282 1.00 43.48  ? 203 THR U C    1 
ATOM   1321 O O    . THR A 1 203 ? 110.454 139.331 125.218 1.00 42.26  ? 203 THR U O    1 
ATOM   1322 C CB   . THR A 1 203 ? 108.772 139.375 128.078 1.00 37.55  ? 203 THR U CB   1 
ATOM   1323 O OG1  . THR A 1 203 ? 107.500 139.081 128.664 1.00 48.26  ? 203 THR U OG1  1 
ATOM   1324 C CG2  . THR A 1 203 ? 108.766 140.810 127.573 1.00 39.94  ? 203 THR U CG2  1 
ATOM   1325 N N    . ALA A 1 204 ? 111.484 138.255 126.910 1.00 47.49  ? 204 ALA U N    1 
ATOM   1326 C CA   . ALA A 1 204 ? 112.812 138.476 126.344 1.00 36.69  ? 204 ALA U CA   1 
ATOM   1327 C C    . ALA A 1 204 ? 112.966 137.772 125.003 1.00 40.74  ? 204 ALA U C    1 
ATOM   1328 O O    . ALA A 1 204 ? 113.539 138.331 124.063 1.00 48.75  ? 204 ALA U O    1 
ATOM   1329 C CB   . ALA A 1 204 ? 113.886 138.003 127.325 1.00 38.87  ? 204 ALA U CB   1 
ATOM   1330 N N    . SER A 1 205 ? 112.466 136.538 124.901 1.00 42.19  ? 205 SER U N    1 
ATOM   1331 C CA   . SER A 1 205 ? 112.561 135.801 123.647 1.00 40.99  ? 205 SER U CA   1 
ATOM   1332 C C    . SER A 1 205 ? 111.783 136.507 122.545 1.00 40.14  ? 205 SER U C    1 
ATOM   1333 O O    . SER A 1 205 ? 112.271 136.633 121.415 1.00 39.58  ? 205 SER U O    1 
ATOM   1334 C CB   . SER A 1 205 ? 112.053 134.372 123.837 1.00 36.02  ? 205 SER U CB   1 
ATOM   1335 O OG   . SER A 1 205 ? 112.761 133.714 124.872 1.00 42.75  ? 205 SER U OG   1 
ATOM   1336 N N    . ILE A 1 206 ? 110.575 136.981 122.860 1.00 41.06  ? 206 ILE U N    1 
ATOM   1337 C CA   . ILE A 1 206 ? 109.770 137.687 121.867 1.00 38.26  ? 206 ILE U CA   1 
ATOM   1338 C C    . ILE A 1 206 ? 110.473 138.964 121.420 1.00 40.49  ? 206 ILE U C    1 
ATOM   1339 O O    . ILE A 1 206 ? 110.540 139.272 120.224 1.00 44.14  ? 206 ILE U O    1 
ATOM   1340 C CB   . ILE A 1 206 ? 108.366 137.981 122.429 1.00 42.71  ? 206 ILE U CB   1 
ATOM   1341 C CG1  . ILE A 1 206 ? 107.567 136.683 122.562 1.00 43.44  ? 206 ILE U CG1  1 
ATOM   1342 C CG2  . ILE A 1 206 ? 107.625 138.970 121.541 1.00 40.98  ? 206 ILE U CG2  1 
ATOM   1343 C CD1  . ILE A 1 206 ? 106.158 136.883 123.071 1.00 43.37  ? 206 ILE U CD1  1 
ATOM   1344 N N    . LEU A 1 207 ? 111.007 139.731 122.377 1.00 40.81  ? 207 LEU U N    1 
ATOM   1345 C CA   . LEU A 1 207 ? 111.682 140.978 122.030 1.00 39.45  ? 207 LEU U CA   1 
ATOM   1346 C C    . LEU A 1 207 ? 112.917 140.728 121.174 1.00 42.24  ? 207 LEU U C    1 
ATOM   1347 O O    . LEU A 1 207 ? 113.152 141.439 120.189 1.00 42.83  ? 207 LEU U O    1 
ATOM   1348 C CB   . LEU A 1 207 ? 112.054 141.749 123.297 1.00 43.80  ? 207 LEU U CB   1 
ATOM   1349 C CG   . LEU A 1 207 ? 110.907 142.449 124.030 1.00 48.71  ? 207 LEU U CG   1 
ATOM   1350 C CD1  . LEU A 1 207 ? 111.429 143.197 125.244 1.00 43.39  ? 207 LEU U CD1  1 
ATOM   1351 C CD2  . LEU A 1 207 ? 110.170 143.392 123.095 1.00 43.41  ? 207 LEU U CD2  1 
ATOM   1352 N N    . ILE A 1 208 ? 113.717 139.717 121.532 1.00 37.79  ? 208 ILE U N    1 
ATOM   1353 C CA   . ILE A 1 208 ? 114.920 139.414 120.762 1.00 37.41  ? 208 ILE U CA   1 
ATOM   1354 C C    . ILE A 1 208 ? 114.548 138.959 119.357 1.00 40.63  ? 208 ILE U C    1 
ATOM   1355 O O    . ILE A 1 208 ? 115.174 139.367 118.369 1.00 41.81  ? 208 ILE U O    1 
ATOM   1356 C CB   . ILE A 1 208 ? 115.782 138.368 121.494 1.00 37.44  ? 208 ILE U CB   1 
ATOM   1357 C CG1  . ILE A 1 208 ? 116.429 138.990 122.731 1.00 39.83  ? 208 ILE U CG1  1 
ATOM   1358 C CG2  . ILE A 1 208 ? 116.850 137.799 120.571 1.00 37.97  ? 208 ILE U CG2  1 
ATOM   1359 C CD1  . ILE A 1 208 ? 117.336 138.047 123.482 1.00 37.03  ? 208 ILE U CD1  1 
ATOM   1360 N N    . SER A 1 209 ? 113.520 138.114 119.244 1.00 45.15  ? 209 SER U N    1 
ATOM   1361 C CA   . SER A 1 209 ? 113.085 137.647 117.934 1.00 34.86  ? 209 SER U CA   1 
ATOM   1362 C C    . SER A 1 209 ? 112.608 138.805 117.069 1.00 33.42  ? 209 SER U C    1 
ATOM   1363 O O    . SER A 1 209 ? 112.958 138.888 115.887 1.00 40.45  ? 209 SER U O    1 
ATOM   1364 C CB   . SER A 1 209 ? 111.985 136.601 118.091 1.00 33.52  ? 209 SER U CB   1 
ATOM   1365 O OG   . SER A 1 209 ? 112.523 135.340 118.443 1.00 43.73  ? 209 SER U OG   1 
ATOM   1366 N N    . CYS A 1 210 ? 111.811 139.713 117.639 1.00 38.57  ? 210 CYS U N    1 
ATOM   1367 C CA   . CYS A 1 210 ? 111.307 140.840 116.858 1.00 36.12  ? 210 CYS U CA   1 
ATOM   1368 C C    . CYS A 1 210 ? 112.431 141.788 116.453 1.00 38.54  ? 210 CYS U C    1 
ATOM   1369 O O    . CYS A 1 210 ? 112.443 142.297 115.327 1.00 37.99  ? 210 CYS U O    1 
ATOM   1370 C CB   . CYS A 1 210 ? 110.232 141.583 117.649 1.00 36.32  ? 210 CYS U CB   1 
ATOM   1371 S SG   . CYS A 1 210 ? 108.672 140.686 117.810 1.00 48.25  ? 210 CYS U SG   1 
ATOM   1372 N N    . CYS A 1 211 ? 113.390 142.032 117.352 1.00 44.99  ? 211 CYS U N    1 
ATOM   1373 C CA   . CYS A 1 211 ? 114.509 142.903 117.010 1.00 42.89  ? 211 CYS U CA   1 
ATOM   1374 C C    . CYS A 1 211 ? 115.370 142.288 115.914 1.00 41.91  ? 211 CYS U C    1 
ATOM   1375 O O    . CYS A 1 211 ? 115.812 142.990 114.997 1.00 46.46  ? 211 CYS U O    1 
ATOM   1376 C CB   . CYS A 1 211 ? 115.346 143.201 118.252 1.00 46.03  ? 211 CYS U CB   1 
ATOM   1377 S SG   . CYS A 1 211 ? 114.740 144.587 119.239 1.00 61.23  ? 211 CYS U SG   1 
ATOM   1378 N N    . ALA A 1 212 ? 115.627 140.980 115.995 1.00 36.73  ? 212 ALA U N    1 
ATOM   1379 C CA   . ALA A 1 212 ? 116.389 140.312 114.947 1.00 33.46  ? 212 ALA U CA   1 
ATOM   1380 C C    . ALA A 1 212 ? 115.627 140.330 113.628 1.00 37.98  ? 212 ALA U C    1 
ATOM   1381 O O    . ALA A 1 212 ? 116.227 140.504 112.562 1.00 33.27  ? 212 ALA U O    1 
ATOM   1382 C CB   . ALA A 1 212 ? 116.716 138.879 115.363 1.00 28.61  ? 212 ALA U CB   1 
ATOM   1383 N N    . SER A 1 213 ? 114.306 140.140 113.682 1.00 38.11  ? 213 SER U N    1 
ATOM   1384 C CA   . SER A 1 213 ? 113.478 140.123 112.484 1.00 25.21  ? 213 SER U CA   1 
ATOM   1385 C C    . SER A 1 213 ? 113.303 141.509 111.875 1.00 33.01  ? 213 SER U C    1 
ATOM   1386 O O    . SER A 1 213 ? 112.911 141.606 110.708 1.00 33.80  ? 213 SER U O    1 
ATOM   1387 C CB   . SER A 1 213 ? 112.111 139.519 112.800 1.00 31.20  ? 213 SER U CB   1 
ATOM   1388 O OG   . SER A 1 213 ? 112.240 138.193 113.274 1.00 41.35  ? 213 SER U OG   1 
ATOM   1389 N N    . ALA A 1 214 ? 113.563 142.573 112.639 1.00 40.78  ? 214 ALA U N    1 
ATOM   1390 C CA   . ALA A 1 214 ? 113.534 143.907 112.048 1.00 33.07  ? 214 ALA U CA   1 
ATOM   1391 C C    . ALA A 1 214 ? 114.546 144.016 110.915 1.00 37.51  ? 214 ALA U C    1 
ATOM   1392 O O    . ALA A 1 214 ? 114.249 144.582 109.859 1.00 41.94  ? 214 ALA U O    1 
ATOM   1393 C CB   . ALA A 1 214 ? 113.802 144.966 113.116 1.00 34.86  ? 214 ALA U CB   1 
ATOM   1394 N N    . MET A 1 215 ? 115.748 143.480 111.116 1.00 41.91  ? 215 MET U N    1 
ATOM   1395 C CA   . MET A 1 215 ? 116.639 143.187 110.008 1.00 42.32  ? 215 MET U CA   1 
ATOM   1396 C C    . MET A 1 215 ? 116.410 141.740 109.569 1.00 48.69  ? 215 MET U C    1 
ATOM   1397 O O    . MET A 1 215 ? 115.502 141.062 110.056 1.00 57.69  ? 215 MET U O    1 
ATOM   1398 C CB   . MET A 1 215 ? 118.082 143.501 110.402 1.00 38.79  ? 215 MET U CB   1 
ATOM   1399 C CG   . MET A 1 215 ? 118.721 142.575 111.422 1.00 47.88  ? 215 MET U CG   1 
ATOM   1400 S SD   . MET A 1 215 ? 120.509 142.826 111.497 1.00 56.94  ? 215 MET U SD   1 
ATOM   1401 C CE   . MET A 1 215 ? 121.097 141.154 111.719 1.00 40.75  ? 215 MET U CE   1 
ATOM   1402 N N    . TYR A 1 216 ? 117.263 141.226 108.672 1.00 32.37  ? 216 TYR U N    1 
ATOM   1403 C CA   . TYR A 1 216 ? 117.045 139.873 108.080 1.00 37.48  ? 216 TYR U CA   1 
ATOM   1404 C C    . TYR A 1 216 ? 115.933 140.006 107.031 1.00 40.15  ? 216 TYR U C    1 
ATOM   1405 O O    . TYR A 1 216 ? 115.891 139.176 106.103 1.00 47.86  ? 216 TYR U O    1 
ATOM   1406 C CB   . TYR A 1 216 ? 116.605 138.795 109.082 1.00 27.88  ? 216 TYR U CB   1 
ATOM   1407 C CG   . TYR A 1 216 ? 117.620 138.170 110.010 1.00 31.56  ? 216 TYR U CG   1 
ATOM   1408 C CD1  . TYR A 1 216 ? 118.987 138.256 109.798 1.00 32.45  ? 216 TYR U CD1  1 
ATOM   1409 C CD2  . TYR A 1 216 ? 117.190 137.446 111.112 1.00 38.71  ? 216 TYR U CD2  1 
ATOM   1410 C CE1  . TYR A 1 216 ? 119.889 137.656 110.666 1.00 33.95  ? 216 TYR U CE1  1 
ATOM   1411 C CE2  . TYR A 1 216 ? 118.078 136.842 111.987 1.00 37.31  ? 216 TYR U CE2  1 
ATOM   1412 C CZ   . TYR A 1 216 ? 119.438 136.940 111.763 1.00 37.48  ? 216 TYR U CZ   1 
ATOM   1413 O OH   . TYR A 1 216 ? 120.324 136.348 112.629 1.00 38.93  ? 216 TYR U OH   1 
ATOM   1414 N N    . THR A 1 217 ? 115.060 141.014 107.177 1.00 36.00  ? 217 THR U N    1 
ATOM   1415 C CA   . THR A 1 217 ? 113.910 141.186 106.249 1.00 33.97  ? 217 THR U CA   1 
ATOM   1416 C C    . THR A 1 217 ? 114.349 142.009 105.027 1.00 40.30  ? 217 THR U C    1 
ATOM   1417 O O    . THR A 1 217 ? 114.270 141.457 103.911 1.00 44.95  ? 217 THR U O    1 
ATOM   1418 C CB   . THR A 1 217 ? 112.694 141.760 106.993 1.00 37.72  ? 217 THR U CB   1 
ATOM   1419 O OG1  . THR A 1 217 ? 112.075 140.690 107.708 1.00 37.82  ? 217 THR U OG1  1 
ATOM   1420 C CG2  . THR A 1 217 ? 111.685 142.415 106.077 1.00 38.27  ? 217 THR U CG2  1 
ATOM   1421 N N    . PRO A 1 218 ? 114.814 143.278 105.151 1.00 38.24  ? 218 PRO U N    1 
ATOM   1422 C CA   . PRO A 1 218 ? 115.136 144.078 103.968 1.00 38.84  ? 218 PRO U CA   1 
ATOM   1423 C C    . PRO A 1 218 ? 116.519 143.671 103.444 1.00 40.14  ? 218 PRO U C    1 
ATOM   1424 O O    . PRO A 1 218 ? 116.719 143.720 102.245 1.00 43.86  ? 218 PRO U O    1 
ATOM   1425 C CB   . PRO A 1 218 ? 115.191 145.511 104.513 1.00 38.62  ? 218 PRO U CB   1 
ATOM   1426 C CG   . PRO A 1 218 ? 115.653 145.335 105.943 1.00 37.61  ? 218 PRO U CG   1 
ATOM   1427 C CD   . PRO A 1 218 ? 115.029 144.031 106.399 1.00 31.84  ? 218 PRO U CD   1 
ATOM   1428 N N    . ILE A 1 219 ? 117.429 143.279 104.341 1.00 37.17  ? 219 ILE U N    1 
ATOM   1429 C CA   . ILE A 1 219 ? 118.784 142.928 103.932 1.00 37.78  ? 219 ILE U CA   1 
ATOM   1430 C C    . ILE A 1 219 ? 118.853 141.649 103.097 1.00 40.18  ? 219 ILE U C    1 
ATOM   1431 O O    . ILE A 1 219 ? 119.676 141.560 102.178 1.00 46.61  ? 219 ILE U O    1 
ATOM   1432 C CB   . ILE A 1 219 ? 119.681 142.822 105.181 1.00 36.12  ? 219 ILE U CB   1 
ATOM   1433 C CG1  . ILE A 1 219 ? 119.822 144.182 105.871 1.00 38.67  ? 219 ILE U CG1  1 
ATOM   1434 C CG2  . ILE A 1 219 ? 121.063 142.296 104.822 1.00 32.41  ? 219 ILE U CG2  1 
ATOM   1435 C CD1  . ILE A 1 219 ? 119.945 145.354 104.924 1.00 37.81  ? 219 ILE U CD1  1 
ATOM   1436 N N    . GLU A 1 220 ? 118.008 140.645 103.356 1.00 40.18  ? 220 GLU U N    1 
ATOM   1437 C CA   . GLU A 1 220 ? 118.005 139.468 102.488 1.00 40.33  ? 220 GLU U CA   1 
ATOM   1438 C C    . GLU A 1 220 ? 116.613 139.058 101.998 1.00 43.63  ? 220 GLU U C    1 
ATOM   1439 O O    . GLU A 1 220 ? 116.209 137.918 102.202 1.00 52.26  ? 220 GLU U O    1 
ATOM   1440 C CB   . GLU A 1 220 ? 118.652 138.288 103.209 1.00 34.74  ? 220 GLU U CB   1 
ATOM   1441 C CG   . GLU A 1 220 ? 118.833 138.490 104.701 1.00 40.54  ? 220 GLU U CG   1 
ATOM   1442 C CD   . GLU A 1 220 ? 119.711 137.426 105.320 1.00 45.11  ? 220 GLU U CD   1 
ATOM   1443 O OE1  . GLU A 1 220 ? 120.201 136.556 104.570 1.00 58.12  ? 220 GLU U OE1  1 
ATOM   1444 O OE2  . GLU A 1 220 ? 119.915 137.458 106.551 1.00 44.20  ? 220 GLU U OE2  1 
ATOM   1445 N N    . GLY A 1 221 ? 115.892 139.953 101.321 1.00 44.06  ? 221 GLY U N    1 
ATOM   1446 C CA   . GLY A 1 221 ? 114.659 139.558 100.654 1.00 43.22  ? 221 GLY U CA   1 
ATOM   1447 C C    . GLY A 1 221 ? 113.660 138.660 101.366 1.00 45.83  ? 221 GLY U C    1 
ATOM   1448 O O    . GLY A 1 221 ? 112.955 137.889 100.706 1.00 51.92  ? 221 GLY U O    1 
ATOM   1449 N N    . TRP A 1 222 ? 113.567 138.738 102.688 1.00 33.94  ? 222 TRP U N    1 
ATOM   1450 C CA   . TRP A 1 222 ? 112.730 137.846 103.481 1.00 33.95  ? 222 TRP U CA   1 
ATOM   1451 C C    . TRP A 1 222 ? 111.530 138.588 104.051 1.00 43.06  ? 222 TRP U C    1 
ATOM   1452 O O    . TRP A 1 222 ? 111.591 139.787 104.318 1.00 50.21  ? 222 TRP U O    1 
ATOM   1453 C CB   . TRP A 1 222 ? 113.521 137.225 104.639 1.00 25.85  ? 222 TRP U CB   1 
ATOM   1454 C CG   . TRP A 1 222 ? 114.452 136.108 104.269 1.00 34.61  ? 222 TRP U CG   1 
ATOM   1455 C CD1  . TRP A 1 222 ? 114.707 135.624 103.022 1.00 39.45  ? 222 TRP U CD1  1 
ATOM   1456 C CD2  . TRP A 1 222 ? 115.297 135.376 105.163 1.00 34.84  ? 222 TRP U CD2  1 
ATOM   1457 N NE1  . TRP A 1 222 ? 115.639 134.617 103.085 1.00 34.94  ? 222 TRP U NE1  1 
ATOM   1458 C CE2  . TRP A 1 222 ? 116.018 134.447 104.390 1.00 30.98  ? 222 TRP U CE2  1 
ATOM   1459 C CE3  . TRP A 1 222 ? 115.505 135.407 106.546 1.00 35.22  ? 222 TRP U CE3  1 
ATOM   1460 C CZ2  . TRP A 1 222 ? 116.932 133.557 104.953 1.00 32.11  ? 222 TRP U CZ2  1 
ATOM   1461 C CZ3  . TRP A 1 222 ? 116.411 134.523 107.102 1.00 29.64  ? 222 TRP U CZ3  1 
ATOM   1462 C CH2  . TRP A 1 222 ? 117.113 133.613 106.305 1.00 27.95  ? 222 TRP U CH2  1 
ATOM   1463 N N    . SER A 1 223 ? 110.423 137.866 104.193 1.00 36.14  ? 223 SER U N    1 
ATOM   1464 C CA   . SER A 1 223 ? 109.226 138.412 104.812 1.00 29.24  ? 223 SER U CA   1 
ATOM   1465 C C    . SER A 1 223 ? 109.324 138.268 106.330 1.00 38.17  ? 223 SER U C    1 
ATOM   1466 O O    . SER A 1 223 ? 110.048 137.421 106.853 1.00 46.77  ? 223 SER U O    1 
ATOM   1467 C CB   . SER A 1 223 ? 107.974 137.711 104.290 1.00 37.17  ? 223 SER U CB   1 
ATOM   1468 O OG   . SER A 1 223 ? 107.868 136.394 104.803 1.00 44.26  ? 223 SER U OG   1 
ATOM   1469 N N    . TYR A 1 224 ? 108.594 139.138 107.035 1.00 35.01  ? 224 TYR U N    1 
ATOM   1470 C CA   . TYR A 1 224 ? 108.667 139.165 108.494 1.00 34.28  ? 224 TYR U CA   1 
ATOM   1471 C C    . TYR A 1 224 ? 108.282 137.826 109.119 1.00 38.90  ? 224 TYR U C    1 
ATOM   1472 O O    . TYR A 1 224 ? 108.924 137.379 110.079 1.00 40.58  ? 224 TYR U O    1 
ATOM   1473 C CB   . TYR A 1 224 ? 107.769 140.283 109.028 1.00 35.09  ? 224 TYR U CB   1 
ATOM   1474 C CG   . TYR A 1 224 ? 108.082 140.709 110.443 1.00 42.56  ? 224 TYR U CG   1 
ATOM   1475 C CD1  . TYR A 1 224 ? 109.212 141.465 110.722 1.00 41.74  ? 224 TYR U CD1  1 
ATOM   1476 C CD2  . TYR A 1 224 ? 107.254 140.353 111.497 1.00 42.28  ? 224 TYR U CD2  1 
ATOM   1477 C CE1  . TYR A 1 224 ? 109.506 141.856 112.012 1.00 38.81  ? 224 TYR U CE1  1 
ATOM   1478 C CE2  . TYR A 1 224 ? 107.540 140.739 112.791 1.00 38.74  ? 224 TYR U CE2  1 
ATOM   1479 C CZ   . TYR A 1 224 ? 108.668 141.490 113.042 1.00 38.84  ? 224 TYR U CZ   1 
ATOM   1480 O OH   . TYR A 1 224 ? 108.956 141.880 114.327 1.00 42.92  ? 224 TYR U OH   1 
ATOM   1481 N N    . PHE A 1 225 ? 107.242 137.174 108.594 1.00 38.38  ? 225 PHE U N    1 
ATOM   1482 C CA   . PHE A 1 225 ? 106.870 135.859 109.110 1.00 38.43  ? 225 PHE U CA   1 
ATOM   1483 C C    . PHE A 1 225 ? 107.971 134.830 108.868 1.00 40.55  ? 225 PHE U C    1 
ATOM   1484 O O    . PHE A 1 225 ? 108.247 133.986 109.732 1.00 44.53  ? 225 PHE U O    1 
ATOM   1485 C CB   . PHE A 1 225 ? 105.554 135.397 108.483 1.00 39.92  ? 225 PHE U CB   1 
ATOM   1486 C CG   . PHE A 1 225 ? 105.088 134.060 108.979 1.00 45.35  ? 225 PHE U CG   1 
ATOM   1487 C CD1  . PHE A 1 225 ? 104.886 133.845 110.331 1.00 40.86  ? 225 PHE U CD1  1 
ATOM   1488 C CD2  . PHE A 1 225 ? 104.865 133.017 108.099 1.00 41.24  ? 225 PHE U CD2  1 
ATOM   1489 C CE1  . PHE A 1 225 ? 104.466 132.617 110.798 1.00 37.29  ? 225 PHE U CE1  1 
ATOM   1490 C CE2  . PHE A 1 225 ? 104.444 131.786 108.559 1.00 40.63  ? 225 PHE U CE2  1 
ATOM   1491 C CZ   . PHE A 1 225 ? 104.243 131.585 109.911 1.00 41.49  ? 225 PHE U CZ   1 
ATOM   1492 N N    . ASP A 1 226 ? 108.614 134.891 107.700 1.00 31.58  ? 226 ASP U N    1 
ATOM   1493 C CA   . ASP A 1 226 ? 109.734 133.999 107.415 1.00 33.29  ? 226 ASP U CA   1 
ATOM   1494 C C    . ASP A 1 226 ? 110.893 134.256 108.367 1.00 39.70  ? 226 ASP U C    1 
ATOM   1495 O O    . ASP A 1 226 ? 111.566 133.318 108.807 1.00 44.66  ? 226 ASP U O    1 
ATOM   1496 C CB   . ASP A 1 226 ? 110.178 134.157 105.963 1.00 36.27  ? 226 ASP U CB   1 
ATOM   1497 C CG   . ASP A 1 226 ? 109.311 133.378 104.998 1.00 42.99  ? 226 ASP U CG   1 
ATOM   1498 O OD1  . ASP A 1 226 ? 108.357 132.712 105.456 1.00 44.85  ? 226 ASP U OD1  1 
ATOM   1499 O OD2  . ASP A 1 226 ? 109.581 133.432 103.779 1.00 43.28  ? 226 ASP U OD2  1 
ATOM   1500 N N    . SER A 1 227 ? 111.148 135.527 108.689 1.00 34.31  ? 227 SER U N    1 
ATOM   1501 C CA   . SER A 1 227 ? 112.208 135.848 109.634 1.00 30.91  ? 227 SER U CA   1 
ATOM   1502 C C    . SER A 1 227 ? 111.899 135.304 111.023 1.00 34.03  ? 227 SER U C    1 
ATOM   1503 O O    . SER A 1 227 ? 112.787 134.770 111.696 1.00 35.43  ? 227 SER U O    1 
ATOM   1504 C CB   . SER A 1 227 ? 112.423 137.362 109.688 1.00 37.01  ? 227 SER U CB   1 
ATOM   1505 O OG   . SER A 1 227 ? 112.765 137.871 108.412 1.00 40.08  ? 227 SER U OG   1 
ATOM   1506 N N    . LEU A 1 228 ? 110.647 135.428 111.472 1.00 32.17  ? 228 LEU U N    1 
ATOM   1507 C CA   . LEU A 1 228 ? 110.279 134.864 112.766 1.00 29.52  ? 228 LEU U CA   1 
ATOM   1508 C C    . LEU A 1 228 ? 110.412 133.344 112.771 1.00 29.10  ? 228 LEU U C    1 
ATOM   1509 O O    . LEU A 1 228 ? 110.877 132.754 113.757 1.00 36.96  ? 228 LEU U O    1 
ATOM   1510 C CB   . LEU A 1 228 ? 108.851 135.278 113.129 1.00 32.44  ? 228 LEU U CB   1 
ATOM   1511 C CG   . LEU A 1 228 ? 108.619 136.754 113.454 1.00 35.71  ? 228 LEU U CG   1 
ATOM   1512 C CD1  . LEU A 1 228 ? 107.142 137.028 113.675 1.00 31.49  ? 228 LEU U CD1  1 
ATOM   1513 C CD2  . LEU A 1 228 ? 109.423 137.175 114.671 1.00 36.11  ? 228 LEU U CD2  1 
ATOM   1514 N N    . TYR A 1 229 ? 110.011 132.692 111.676 1.00 21.50  ? 229 TYR U N    1 
ATOM   1515 C CA   . TYR A 1 229 ? 110.154 131.241 111.572 1.00 23.19  ? 229 TYR U CA   1 
ATOM   1516 C C    . TYR A 1 229 ? 111.623 130.824 111.620 1.00 25.79  ? 229 TYR U C    1 
ATOM   1517 O O    . TYR A 1 229 ? 111.985 129.867 112.317 1.00 25.39  ? 229 TYR U O    1 
ATOM   1518 C CB   . TYR A 1 229 ? 109.473 130.752 110.291 1.00 21.53  ? 229 TYR U CB   1 
ATOM   1519 C CG   . TYR A 1 229 ? 109.686 129.291 109.963 1.00 27.48  ? 229 TYR U CG   1 
ATOM   1520 C CD1  . TYR A 1 229 ? 109.056 128.294 110.692 1.00 22.63  ? 229 TYR U CD1  1 
ATOM   1521 C CD2  . TYR A 1 229 ? 110.493 128.913 108.899 1.00 30.75  ? 229 TYR U CD2  1 
ATOM   1522 C CE1  . TYR A 1 229 ? 109.242 126.960 110.387 1.00 20.26  ? 229 TYR U CE1  1 
ATOM   1523 C CE2  . TYR A 1 229 ? 110.683 127.584 108.589 1.00 31.26  ? 229 TYR U CE2  1 
ATOM   1524 C CZ   . TYR A 1 229 ? 110.056 126.614 109.332 1.00 26.33  ? 229 TYR U CZ   1 
ATOM   1525 O OH   . TYR A 1 229 ? 110.249 125.288 109.018 1.00 28.18  ? 229 TYR U OH   1 
ATOM   1526 N N    . PHE A 1 230 ? 112.485 131.545 110.895 1.00 24.37  ? 230 PHE U N    1 
ATOM   1527 C CA   . PHE A 1 230 ? 113.916 131.263 110.931 1.00 22.57  ? 230 PHE U CA   1 
ATOM   1528 C C    . PHE A 1 230 ? 114.484 131.467 112.329 1.00 29.80  ? 230 PHE U C    1 
ATOM   1529 O O    . PHE A 1 230 ? 115.315 130.676 112.791 1.00 30.36  ? 230 PHE U O    1 
ATOM   1530 C CB   . PHE A 1 230 ? 114.654 132.150 109.925 1.00 26.26  ? 230 PHE U CB   1 
ATOM   1531 C CG   . PHE A 1 230 ? 116.136 132.230 110.158 1.00 33.76  ? 230 PHE U CG   1 
ATOM   1532 C CD1  . PHE A 1 230 ? 116.968 131.182 109.798 1.00 30.15  ? 230 PHE U CD1  1 
ATOM   1533 C CD2  . PHE A 1 230 ? 116.701 133.350 110.750 1.00 30.47  ? 230 PHE U CD2  1 
ATOM   1534 C CE1  . PHE A 1 230 ? 118.329 131.253 110.014 1.00 25.46  ? 230 PHE U CE1  1 
ATOM   1535 C CE2  . PHE A 1 230 ? 118.062 133.423 110.972 1.00 25.00  ? 230 PHE U CE2  1 
ATOM   1536 C CZ   . PHE A 1 230 ? 118.877 132.374 110.604 1.00 22.65  ? 230 PHE U CZ   1 
ATOM   1537 N N    . CYS A 1 231 ? 114.058 132.533 113.011 1.00 31.72  ? 231 CYS U N    1 
ATOM   1538 C CA   . CYS A 1 231 ? 114.534 132.789 114.364 1.00 19.34  ? 231 CYS U CA   1 
ATOM   1539 C C    . CYS A 1 231 ? 114.157 131.652 115.299 1.00 23.62  ? 231 CYS U C    1 
ATOM   1540 O O    . CYS A 1 231 ? 114.983 131.196 116.097 1.00 32.90  ? 231 CYS U O    1 
ATOM   1541 C CB   . CYS A 1 231 ? 113.980 134.119 114.879 1.00 16.35  ? 231 CYS U CB   1 
ATOM   1542 S SG   . CYS A 1 231 ? 114.755 135.583 114.158 1.00 38.24  ? 231 CYS U SG   1 
ATOM   1543 N N    . PHE A 1 232 ? 112.911 131.172 115.210 1.00 26.83  ? 232 PHE U N    1 
ATOM   1544 C CA   . PHE A 1 232 ? 112.502 130.062 116.065 1.00 21.99  ? 232 PHE U CA   1 
ATOM   1545 C C    . PHE A 1 232 ? 113.288 128.796 115.745 1.00 17.80  ? 232 PHE U C    1 
ATOM   1546 O O    . PHE A 1 232 ? 113.705 128.073 116.657 1.00 26.37  ? 232 PHE U O    1 
ATOM   1547 C CB   . PHE A 1 232 ? 111.003 129.794 115.936 1.00 20.80  ? 232 PHE U CB   1 
ATOM   1548 C CG   . PHE A 1 232 ? 110.538 128.621 116.753 1.00 29.29  ? 232 PHE U CG   1 
ATOM   1549 C CD1  . PHE A 1 232 ? 110.342 128.741 118.117 1.00 27.02  ? 232 PHE U CD1  1 
ATOM   1550 C CD2  . PHE A 1 232 ? 110.325 127.385 116.162 1.00 28.93  ? 232 PHE U CD2  1 
ATOM   1551 C CE1  . PHE A 1 232 ? 109.931 127.659 118.872 1.00 20.05  ? 232 PHE U CE1  1 
ATOM   1552 C CE2  . PHE A 1 232 ? 109.915 126.301 116.908 1.00 28.83  ? 232 PHE U CE2  1 
ATOM   1553 C CZ   . PHE A 1 232 ? 109.717 126.439 118.266 1.00 22.79  ? 232 PHE U CZ   1 
ATOM   1554 N N    . VAL A 1 233 ? 113.497 128.507 114.460 1.00 22.71  ? 233 VAL U N    1 
ATOM   1555 C CA   . VAL A 1 233 ? 114.185 127.270 114.094 1.00 22.73  ? 233 VAL U CA   1 
ATOM   1556 C C    . VAL A 1 233 ? 115.643 127.306 114.537 1.00 24.47  ? 233 VAL U C    1 
ATOM   1557 O O    . VAL A 1 233 ? 116.187 126.304 115.018 1.00 19.67  ? 233 VAL U O    1 
ATOM   1558 C CB   . VAL A 1 233 ? 114.056 127.006 112.580 1.00 22.34  ? 233 VAL U CB   1 
ATOM   1559 C CG1  . VAL A 1 233 ? 114.931 125.836 112.165 1.00 16.90  ? 233 VAL U CG1  1 
ATOM   1560 C CG2  . VAL A 1 233 ? 112.608 126.729 112.219 1.00 24.10  ? 233 VAL U CG2  1 
ATOM   1561 N N    . ALA A 1 234 ? 116.303 128.459 114.392 1.00 27.16  ? 234 ALA U N    1 
ATOM   1562 C CA   . ALA A 1 234 ? 117.710 128.554 114.772 1.00 19.20  ? 234 ALA U CA   1 
ATOM   1563 C C    . ALA A 1 234 ? 117.888 128.597 116.287 1.00 25.79  ? 234 ALA U C    1 
ATOM   1564 O O    . ALA A 1 234 ? 118.796 127.955 116.825 1.00 29.40  ? 234 ALA U O    1 
ATOM   1565 C CB   . ALA A 1 234 ? 118.344 129.787 114.128 1.00 17.75  ? 234 ALA U CB   1 
ATOM   1566 N N    . PHE A 1 235 ? 117.035 129.345 116.990 1.00 27.82  ? 235 PHE U N    1 
ATOM   1567 C CA   . PHE A 1 235 ? 117.219 129.534 118.429 1.00 17.33  ? 235 PHE U CA   1 
ATOM   1568 C C    . PHE A 1 235 ? 116.999 128.240 119.203 1.00 22.79  ? 235 PHE U C    1 
ATOM   1569 O O    . PHE A 1 235 ? 117.674 127.995 120.209 1.00 24.12  ? 235 PHE U O    1 
ATOM   1570 C CB   . PHE A 1 235 ? 116.286 130.632 118.944 1.00 15.17  ? 235 PHE U CB   1 
ATOM   1571 C CG   . PHE A 1 235 ? 116.643 132.014 118.467 1.00 24.61  ? 235 PHE U CG   1 
ATOM   1572 C CD1  . PHE A 1 235 ? 117.815 132.247 117.767 1.00 26.65  ? 235 PHE U CD1  1 
ATOM   1573 C CD2  . PHE A 1 235 ? 115.801 133.085 118.726 1.00 24.11  ? 235 PHE U CD2  1 
ATOM   1574 C CE1  . PHE A 1 235 ? 118.140 133.515 117.330 1.00 24.93  ? 235 PHE U CE1  1 
ATOM   1575 C CE2  . PHE A 1 235 ? 116.121 134.357 118.294 1.00 17.76  ? 235 PHE U CE2  1 
ATOM   1576 C CZ   . PHE A 1 235 ? 117.289 134.572 117.594 1.00 23.05  ? 235 PHE U CZ   1 
ATOM   1577 N N    . SER A 1 236 ? 116.056 127.408 118.764 1.00 24.23  ? 236 SER U N    1 
ATOM   1578 C CA   . SER A 1 236 ? 115.779 126.140 119.424 1.00 24.09  ? 236 SER U CA   1 
ATOM   1579 C C    . SER A 1 236 ? 116.802 125.056 119.102 1.00 30.44  ? 236 SER U C    1 
ATOM   1580 O O    . SER A 1 236 ? 116.662 123.936 119.605 1.00 28.25  ? 236 SER U O    1 
ATOM   1581 C CB   . SER A 1 236 ? 114.380 125.649 119.049 1.00 21.96  ? 236 SER U CB   1 
ATOM   1582 O OG   . SER A 1 236 ? 114.253 125.490 117.646 1.00 24.48  ? 236 SER U OG   1 
ATOM   1583 N N    . THR A 1 237 ? 117.814 125.361 118.286 1.00 31.51  ? 237 THR U N    1 
ATOM   1584 C CA   . THR A 1 237 ? 118.861 124.412 117.888 1.00 21.39  ? 237 THR U CA   1 
ATOM   1585 C C    . THR A 1 237 ? 118.294 123.207 117.137 1.00 25.58  ? 237 THR U C    1 
ATOM   1586 O O    . THR A 1 237 ? 118.865 122.116 117.177 1.00 34.37  ? 237 THR U O    1 
ATOM   1587 C CB   . THR A 1 237 ? 119.695 123.941 119.086 1.00 25.15  ? 237 THR U CB   1 
ATOM   1588 O OG1  . THR A 1 237 ? 118.885 123.151 119.966 1.00 31.81  ? 237 THR U OG1  1 
ATOM   1589 C CG2  . THR A 1 237 ? 120.249 125.132 119.851 1.00 24.84  ? 237 THR U CG2  1 
ATOM   1590 N N    . ILE A 1 238 ? 117.177 123.400 116.438 1.00 21.19  ? 238 ILE U N    1 
ATOM   1591 C CA   . ILE A 1 238 ? 116.690 122.378 115.515 1.00 20.74  ? 238 ILE U CA   1 
ATOM   1592 C C    . ILE A 1 238 ? 117.501 122.401 114.226 1.00 27.65  ? 238 ILE U C    1 
ATOM   1593 O O    . ILE A 1 238 ? 118.038 121.375 113.794 1.00 39.51  ? 238 ILE U O    1 
ATOM   1594 C CB   . ILE A 1 238 ? 115.186 122.565 115.250 1.00 24.31  ? 238 ILE U CB   1 
ATOM   1595 C CG1  . ILE A 1 238 ? 114.383 122.239 116.513 1.00 25.45  ? 238 ILE U CG1  1 
ATOM   1596 C CG2  . ILE A 1 238 ? 114.734 121.699 114.090 1.00 16.16  ? 238 ILE U CG2  1 
ATOM   1597 C CD1  . ILE A 1 238 ? 112.883 122.337 116.334 1.00 21.09  ? 238 ILE U CD1  1 
ATOM   1598 N N    . GLY A 1 239 ? 117.592 123.565 113.590 1.00 26.36  ? 239 GLY U N    1 
ATOM   1599 C CA   . GLY A 1 239 ? 118.461 123.761 112.446 1.00 14.73  ? 239 GLY U CA   1 
ATOM   1600 C C    . GLY A 1 239 ? 118.154 122.989 111.180 1.00 26.55  ? 239 GLY U C    1 
ATOM   1601 O O    . GLY A 1 239 ? 119.045 122.339 110.627 1.00 38.12  ? 239 GLY U O    1 
ATOM   1602 N N    . PHE A 1 240 ? 116.892 123.027 110.734 1.00 27.31  ? 240 PHE U N    1 
ATOM   1603 C CA   . PHE A 1 240 ? 116.501 122.366 109.489 1.00 20.68  ? 240 PHE U CA   1 
ATOM   1604 C C    . PHE A 1 240 ? 117.489 122.645 108.362 1.00 27.38  ? 240 PHE U C    1 
ATOM   1605 O O    . PHE A 1 240 ? 117.896 121.732 107.635 1.00 34.19  ? 240 PHE U O    1 
ATOM   1606 C CB   . PHE A 1 240 ? 115.092 122.798 109.079 1.00 21.52  ? 240 PHE U CB   1 
ATOM   1607 C CG   . PHE A 1 240 ? 114.001 122.213 109.927 1.00 24.56  ? 240 PHE U CG   1 
ATOM   1608 C CD1  . PHE A 1 240 ? 114.121 120.934 110.449 1.00 27.84  ? 240 PHE U CD1  1 
ATOM   1609 C CD2  . PHE A 1 240 ? 112.846 122.934 110.187 1.00 22.86  ? 240 PHE U CD2  1 
ATOM   1610 C CE1  . PHE A 1 240 ? 113.113 120.390 111.220 1.00 28.66  ? 240 PHE U CE1  1 
ATOM   1611 C CE2  . PHE A 1 240 ? 111.837 122.391 110.961 1.00 26.18  ? 240 PHE U CE2  1 
ATOM   1612 C CZ   . PHE A 1 240 ? 111.969 121.119 111.477 1.00 23.28  ? 240 PHE U CZ   1 
ATOM   1613 N N    . GLY A 1 241 ? 117.884 123.909 108.195 1.00 32.55  ? 241 GLY U N    1 
ATOM   1614 C CA   . GLY A 1 241 ? 118.797 124.286 107.137 1.00 31.26  ? 241 GLY U CA   1 
ATOM   1615 C C    . GLY A 1 241 ? 118.147 124.842 105.888 1.00 35.49  ? 241 GLY U C    1 
ATOM   1616 O O    . GLY A 1 241 ? 118.867 125.232 104.960 1.00 39.69  ? 241 GLY U O    1 
ATOM   1617 N N    . ASP A 1 242 ? 116.814 124.866 105.825 1.00 33.48  ? 242 ASP U N    1 
ATOM   1618 C CA   . ASP A 1 242 ? 116.129 125.453 104.674 1.00 31.17  ? 242 ASP U CA   1 
ATOM   1619 C C    . ASP A 1 242 ? 116.396 126.950 104.560 1.00 38.09  ? 242 ASP U C    1 
ATOM   1620 O O    . ASP A 1 242 ? 116.575 127.473 103.455 1.00 42.30  ? 242 ASP U O    1 
ATOM   1621 C CB   . ASP A 1 242 ? 114.629 125.175 104.759 1.00 31.07  ? 242 ASP U CB   1 
ATOM   1622 C CG   . ASP A 1 242 ? 114.060 125.443 106.138 1.00 44.04  ? 242 ASP U CG   1 
ATOM   1623 O OD1  . ASP A 1 242 ? 114.842 125.498 107.108 1.00 47.36  ? 242 ASP U OD1  1 
ATOM   1624 O OD2  . ASP A 1 242 ? 112.827 125.603 106.251 1.00 44.37  ? 242 ASP U OD2  1 
ATOM   1625 N N    . LEU A 1 243 ? 116.410 127.662 105.685 1.00 39.02  ? 243 LEU U N    1 
ATOM   1626 C CA   . LEU A 1 243 ? 116.758 129.079 105.726 1.00 33.22  ? 243 LEU U CA   1 
ATOM   1627 C C    . LEU A 1 243 ? 118.019 129.268 106.555 1.00 34.79  ? 243 LEU U C    1 
ATOM   1628 O O    . LEU A 1 243 ? 118.018 128.991 107.758 1.00 43.76  ? 243 LEU U O    1 
ATOM   1629 C CB   . LEU A 1 243 ? 115.615 129.920 106.297 1.00 34.78  ? 243 LEU U CB   1 
ATOM   1630 C CG   . LEU A 1 243 ? 114.343 130.050 105.459 1.00 35.11  ? 243 LEU U CG   1 
ATOM   1631 C CD1  . LEU A 1 243 ? 113.284 130.831 106.217 1.00 35.00  ? 243 LEU U CD1  1 
ATOM   1632 C CD2  . LEU A 1 243 ? 114.649 130.719 104.131 1.00 34.56  ? 243 LEU U CD2  1 
ATOM   1633 N N    . VAL A 1 244 ? 119.094 129.726 105.914 1.00 33.15  ? 244 VAL U N    1 
ATOM   1634 C CA   . VAL A 1 244 ? 120.343 130.047 106.597 1.00 31.50  ? 244 VAL U CA   1 
ATOM   1635 C C    . VAL A 1 244 ? 120.726 131.484 106.267 1.00 35.52  ? 244 VAL U C    1 
ATOM   1636 O O    . VAL A 1 244 ? 120.638 131.915 105.114 1.00 35.30  ? 244 VAL U O    1 
ATOM   1637 C CB   . VAL A 1 244 ? 121.480 129.077 106.204 1.00 28.64  ? 244 VAL U CB   1 
ATOM   1638 C CG1  . VAL A 1 244 ? 122.723 129.346 107.038 1.00 28.24  ? 244 VAL U CG1  1 
ATOM   1639 C CG2  . VAL A 1 244 ? 121.028 127.633 106.363 1.00 34.71  ? 244 VAL U CG2  1 
ATOM   1640 N N    . SER A 1 245 ? 121.144 132.223 107.290 1.00 38.72  ? 245 SER U N    1 
ATOM   1641 C CA   . SER A 1 245 ? 121.433 133.645 107.185 1.00 28.60  ? 245 SER U CA   1 
ATOM   1642 C C    . SER A 1 245 ? 122.904 133.910 106.876 1.00 36.01  ? 245 SER U C    1 
ATOM   1643 O O    . SER A 1 245 ? 123.781 133.093 107.175 1.00 41.40  ? 245 SER U O    1 
ATOM   1644 C CB   . SER A 1 245 ? 121.047 134.361 108.480 1.00 28.68  ? 245 SER U CB   1 
ATOM   1645 O OG   . SER A 1 245 ? 121.274 135.753 108.380 1.00 41.73  ? 245 SER U OG   1 
ATOM   1646 N N    . SER A 1 246 ? 123.157 135.067 106.254 1.00 32.79  ? 246 SER U N    1 
ATOM   1647 C CA   . SER A 1 246 ? 124.508 135.616 106.084 1.00 28.84  ? 246 SER U CA   1 
ATOM   1648 C C    . SER A 1 246 ? 125.377 134.776 105.146 1.00 30.01  ? 246 SER U C    1 
ATOM   1649 O O    . SER A 1 246 ? 126.483 134.357 105.502 1.00 38.68  ? 246 SER U O    1 
ATOM   1650 C CB   . SER A 1 246 ? 125.195 135.809 107.440 1.00 33.98  ? 246 SER U CB   1 
ATOM   1651 O OG   . SER A 1 246 ? 126.539 136.220 107.280 1.00 38.55  ? 246 SER U OG   1 
ATOM   1652 N N    . GLN A 1 247 ? 124.879 134.530 103.935 1.00 34.04  ? 247 GLN U N    1 
ATOM   1653 C CA   . GLN A 1 247 ? 125.730 133.998 102.866 1.00 37.06  ? 247 GLN U CA   1 
ATOM   1654 C C    . GLN A 1 247 ? 125.187 134.509 101.529 1.00 35.58  ? 247 GLN U C    1 
ATOM   1655 O O    . GLN A 1 247 ? 124.314 133.888 100.921 1.00 40.80  ? 247 GLN U O    1 
ATOM   1656 C CB   . GLN A 1 247 ? 125.796 132.482 102.903 1.00 36.23  ? 247 GLN U CB   1 
ATOM   1657 C CG   . GLN A 1 247 ? 124.509 131.808 103.329 1.00 31.37  ? 247 GLN U CG   1 
ATOM   1658 C CD   . GLN A 1 247 ? 124.775 130.559 104.135 1.00 36.02  ? 247 GLN U CD   1 
ATOM   1659 O OE1  . GLN A 1 247 ? 125.687 130.525 104.963 1.00 32.91  ? 247 GLN U OE1  1 
ATOM   1660 N NE2  . GLN A 1 247 ? 123.990 129.519 103.891 1.00 42.66  ? 247 GLN U NE2  1 
ATOM   1661 N N    . ASN A 1 248 ? 125.725 135.647 101.085 1.00 35.48  ? 248 ASN U N    1 
ATOM   1662 C CA   . ASN A 1 248 ? 125.342 136.245 99.812  1.00 36.05  ? 248 ASN U CA   1 
ATOM   1663 C C    . ASN A 1 248 ? 126.528 136.886 99.108  1.00 43.34  ? 248 ASN U C    1 
ATOM   1664 O O    . ASN A 1 248 ? 126.359 137.885 98.398  1.00 53.44  ? 248 ASN U O    1 
ATOM   1665 C CB   . ASN A 1 248 ? 124.232 137.281 100.000 1.00 39.45  ? 248 ASN U CB   1 
ATOM   1666 C CG   . ASN A 1 248 ? 122.850 136.701 99.787  1.00 41.36  ? 248 ASN U CG   1 
ATOM   1667 O OD1  . ASN A 1 248 ? 122.696 135.646 99.173  1.00 44.20  ? 248 ASN U OD1  1 
ATOM   1668 N ND2  . ASN A 1 248 ? 121.836 137.389 100.295 1.00 43.05  ? 248 ASN U ND2  1 
ATOM   1669 N N    . ALA A 1 249 ? 127.734 136.343 99.302  1.00 39.41  ? 249 ALA U N    1 
ATOM   1670 C CA   . ALA A 1 249 ? 128.957 136.934 98.761  1.00 41.37  ? 249 ALA U CA   1 
ATOM   1671 C C    . ALA A 1 249 ? 129.122 138.356 99.285  1.00 48.26  ? 249 ALA U C    1 
ATOM   1672 O O    . ALA A 1 249 ? 129.332 138.552 100.487 1.00 54.72  ? 249 ALA U O    1 
ATOM   1673 C CB   . ALA A 1 249 ? 128.957 136.908 97.228  1.00 38.97  ? 249 ALA U CB   1 
ATOM   1674 N N    . HIS A 1 250 ? 129.050 139.351 98.403  1.00 47.45  ? 250 HIS U N    1 
ATOM   1675 C CA   . HIS A 1 250 ? 129.080 140.737 98.854  1.00 46.90  ? 250 HIS U CA   1 
ATOM   1676 C C    . HIS A 1 250 ? 127.827 141.034 99.670  1.00 44.47  ? 250 HIS U C    1 
ATOM   1677 O O    . HIS A 1 250 ? 126.708 140.732 99.243  1.00 41.58  ? 250 HIS U O    1 
ATOM   1678 C CB   . HIS A 1 250 ? 129.186 141.683 97.661  1.00 47.00  ? 250 HIS U CB   1 
ATOM   1679 C CG   . HIS A 1 250 ? 129.255 143.130 98.041  1.00 50.87  ? 250 HIS U CG   1 
ATOM   1680 N ND1  . HIS A 1 250 ? 128.230 144.018 97.789  1.00 53.16  ? 250 HIS U ND1  1 
ATOM   1681 C CD2  . HIS A 1 250 ? 130.224 143.844 98.659  1.00 48.08  ? 250 HIS U CD2  1 
ATOM   1682 C CE1  . HIS A 1 250 ? 128.567 145.215 98.233  1.00 53.21  ? 250 HIS U CE1  1 
ATOM   1683 N NE2  . HIS A 1 250 ? 129.775 145.137 98.767  1.00 51.82  ? 250 HIS U NE2  1 
ATOM   1684 N N    . TYR A 1 251 ? 128.015 141.633 100.845 1.00 43.60  ? 251 TYR U N    1 
ATOM   1685 C CA   . TYR A 1 251 ? 126.919 141.932 101.765 1.00 43.61  ? 251 TYR U CA   1 
ATOM   1686 C C    . TYR A 1 251 ? 127.060 143.357 102.302 1.00 45.07  ? 251 TYR U C    1 
ATOM   1687 O O    . TYR A 1 251 ? 127.049 143.585 103.513 1.00 50.50  ? 251 TYR U O    1 
ATOM   1688 C CB   . TYR A 1 251 ? 126.898 140.915 102.905 1.00 47.43  ? 251 TYR U CB   1 
ATOM   1689 C CG   . TYR A 1 251 ? 125.619 140.119 103.016 1.00 44.10  ? 251 TYR U CG   1 
ATOM   1690 C CD1  . TYR A 1 251 ? 124.390 140.696 102.728 1.00 36.50  ? 251 TYR U CD1  1 
ATOM   1691 C CD2  . TYR A 1 251 ? 125.645 138.784 103.394 1.00 43.24  ? 251 TYR U CD2  1 
ATOM   1692 C CE1  . TYR A 1 251 ? 123.220 139.968 102.829 1.00 41.45  ? 251 TYR U CE1  1 
ATOM   1693 C CE2  . TYR A 1 251 ? 124.483 138.049 103.491 1.00 37.66  ? 251 TYR U CE2  1 
ATOM   1694 C CZ   . TYR A 1 251 ? 123.276 138.644 103.210 1.00 41.72  ? 251 TYR U CZ   1 
ATOM   1695 O OH   . TYR A 1 251 ? 122.119 137.907 103.306 1.00 42.61  ? 251 TYR U OH   1 
ATOM   1696 N N    . GLU A 1 252 ? 127.160 144.325 101.388 1.00 48.81  ? 252 GLU U N    1 
ATOM   1697 C CA   . GLU A 1 252 ? 127.279 145.740 101.733 1.00 50.74  ? 252 GLU U CA   1 
ATOM   1698 C C    . GLU A 1 252 ? 128.420 145.903 102.739 1.00 57.80  ? 252 GLU U C    1 
ATOM   1699 O O    . GLU A 1 252 ? 129.580 145.650 102.398 1.00 60.37  ? 252 GLU U O    1 
ATOM   1700 C CB   . GLU A 1 252 ? 125.941 146.271 102.267 1.00 47.84  ? 252 GLU U CB   1 
ATOM   1701 C CG   . GLU A 1 252 ? 125.874 147.767 102.590 1.00 52.63  ? 252 GLU U CG   1 
ATOM   1702 C CD   . GLU A 1 252 ? 126.030 148.650 101.366 1.00 58.56  ? 252 GLU U CD   1 
ATOM   1703 O OE1  . GLU A 1 252 ? 125.946 148.130 100.232 1.00 58.69  ? 252 GLU U OE1  1 
ATOM   1704 O OE2  . GLU A 1 252 ? 126.232 149.869 101.537 1.00 56.89  ? 252 GLU U OE2  1 
ATOM   1705 N N    . SER A 1 253 ? 128.114 146.324 103.970 1.00 52.14  ? 253 SER U N    1 
ATOM   1706 C CA   . SER A 1 253 ? 129.163 146.600 104.948 1.00 48.18  ? 253 SER U CA   1 
ATOM   1707 C C    . SER A 1 253 ? 129.920 145.327 105.306 1.00 51.74  ? 253 SER U C    1 
ATOM   1708 O O    . SER A 1 253 ? 131.156 145.298 105.281 1.00 56.47  ? 253 SER U O    1 
ATOM   1709 C CB   . SER A 1 253 ? 128.565 147.245 106.196 1.00 45.75  ? 253 SER U CB   1 
ATOM   1710 O OG   . SER A 1 253 ? 128.025 148.522 105.902 1.00 54.13  ? 253 SER U OG   1 
ATOM   1711 N N    . GLN A 1 254 ? 129.189 144.274 105.675 1.00 45.15  ? 254 GLN U N    1 
ATOM   1712 C CA   . GLN A 1 254 ? 129.706 142.915 105.818 1.00 43.00  ? 254 GLN U CA   1 
ATOM   1713 C C    . GLN A 1 254 ? 130.669 142.751 106.988 1.00 45.94  ? 254 GLN U C    1 
ATOM   1714 O O    . GLN A 1 254 ? 131.080 141.627 107.298 1.00 49.53  ? 254 GLN U O    1 
ATOM   1715 C CB   . GLN A 1 254 ? 130.388 142.470 104.516 1.00 36.85  ? 254 GLN U CB   1 
ATOM   1716 C CG   . GLN A 1 254 ? 130.300 140.979 104.243 1.00 41.91  ? 254 GLN U CG   1 
ATOM   1717 C CD   . GLN A 1 254 ? 131.127 140.557 103.046 1.00 45.37  ? 254 GLN U CD   1 
ATOM   1718 O OE1  . GLN A 1 254 ? 132.033 141.274 102.622 1.00 51.51  ? 254 GLN U OE1  1 
ATOM   1719 N NE2  . GLN A 1 254 ? 130.811 139.399 102.488 1.00 45.60  ? 254 GLN U NE2  1 
ATOM   1720 N N    . GLY A 1 255 ? 131.039 143.845 107.652 1.00 44.80  ? 255 GLY U N    1 
ATOM   1721 C CA   . GLY A 1 255 ? 131.857 143.719 108.842 1.00 39.18  ? 255 GLY U CA   1 
ATOM   1722 C C    . GLY A 1 255 ? 131.030 143.786 110.110 1.00 42.73  ? 255 GLY U C    1 
ATOM   1723 O O    . GLY A 1 255 ? 131.188 142.961 111.013 1.00 49.32  ? 255 GLY U O    1 
ATOM   1724 N N    . LEU A 1 256 ? 130.139 144.776 110.177 1.00 36.44  ? 256 LEU U N    1 
ATOM   1725 C CA   . LEU A 1 256 ? 129.216 144.902 111.301 1.00 33.26  ? 256 LEU U CA   1 
ATOM   1726 C C    . LEU A 1 256 ? 128.079 143.887 111.229 1.00 31.94  ? 256 LEU U C    1 
ATOM   1727 O O    . LEU A 1 256 ? 127.567 143.461 112.269 1.00 40.10  ? 256 LEU U O    1 
ATOM   1728 C CB   . LEU A 1 256 ? 128.640 146.321 111.362 1.00 32.90  ? 256 LEU U CB   1 
ATOM   1729 C CG   . LEU A 1 256 ? 129.495 147.487 111.882 1.00 34.26  ? 256 LEU U CG   1 
ATOM   1730 C CD1  . LEU A 1 256 ? 130.750 147.724 111.050 1.00 35.97  ? 256 LEU U CD1  1 
ATOM   1731 C CD2  . LEU A 1 256 ? 128.660 148.754 111.953 1.00 35.49  ? 256 LEU U CD2  1 
ATOM   1732 N N    . TYR A 1 257 ? 127.684 143.496 110.013 1.00 27.46  ? 257 TYR U N    1 
ATOM   1733 C CA   . TYR A 1 257 ? 126.553 142.591 109.833 1.00 27.66  ? 257 TYR U CA   1 
ATOM   1734 C C    . TYR A 1 257 ? 126.842 141.203 110.400 1.00 33.61  ? 257 TYR U C    1 
ATOM   1735 O O    . TYR A 1 257 ? 125.981 140.607 111.065 1.00 34.32  ? 257 TYR U O    1 
ATOM   1736 C CB   . TYR A 1 257 ? 126.210 142.519 108.343 1.00 29.20  ? 257 TYR U CB   1 
ATOM   1737 C CG   . TYR A 1 257 ? 124.999 141.683 107.997 1.00 34.25  ? 257 TYR U CG   1 
ATOM   1738 C CD1  . TYR A 1 257 ? 123.719 142.127 108.293 1.00 39.15  ? 257 TYR U CD1  1 
ATOM   1739 C CD2  . TYR A 1 257 ? 125.136 140.463 107.346 1.00 31.81  ? 257 TYR U CD2  1 
ATOM   1740 C CE1  . TYR A 1 257 ? 122.610 141.368 107.972 1.00 36.03  ? 257 TYR U CE1  1 
ATOM   1741 C CE2  . TYR A 1 257 ? 124.033 139.703 107.019 1.00 29.73  ? 257 TYR U CE2  1 
ATOM   1742 C CZ   . TYR A 1 257 ? 122.774 140.160 107.334 1.00 34.38  ? 257 TYR U CZ   1 
ATOM   1743 O OH   . TYR A 1 257 ? 121.672 139.403 107.009 1.00 36.82  ? 257 TYR U OH   1 
ATOM   1744 N N    . ARG A 1 258 ? 128.054 140.690 110.184 1.00 32.49  ? 258 ARG U N    1 
ATOM   1745 C CA   . ARG A 1 258 ? 128.412 139.382 110.725 1.00 26.54  ? 258 ARG U CA   1 
ATOM   1746 C C    . ARG A 1 258 ? 128.460 139.410 112.248 1.00 33.72  ? 258 ARG U C    1 
ATOM   1747 O O    . ARG A 1 258 ? 127.997 138.472 112.910 1.00 40.30  ? 258 ARG U O    1 
ATOM   1748 C CB   . ARG A 1 258 ? 129.757 138.933 110.151 1.00 29.14  ? 258 ARG U CB   1 
ATOM   1749 C CG   . ARG A 1 258 ? 129.807 138.923 108.628 1.00 33.79  ? 258 ARG U CG   1 
ATOM   1750 C CD   . ARG A 1 258 ? 131.057 138.236 108.106 1.00 33.93  ? 258 ARG U CD   1 
ATOM   1751 N NE   . ARG A 1 258 ? 130.935 137.860 106.703 1.00 35.85  ? 258 ARG U NE   1 
ATOM   1752 C CZ   . ARG A 1 258 ? 131.959 137.631 105.893 1.00 35.58  ? 258 ARG U CZ   1 
ATOM   1753 N NH1  . ARG A 1 258 ? 133.208 137.743 106.313 1.00 39.81  ? 258 ARG U NH1  1 
ATOM   1754 N NH2  . ARG A 1 258 ? 131.727 137.288 104.629 1.00 31.57  ? 258 ARG U NH2  1 
ATOM   1755 N N    . PHE A 1 259 ? 129.005 140.487 112.815 1.00 33.64  ? 259 PHE U N    1 
ATOM   1756 C CA   . PHE A 1 259 ? 129.058 140.636 114.265 1.00 31.59  ? 259 PHE U CA   1 
ATOM   1757 C C    . PHE A 1 259 ? 127.657 140.694 114.866 1.00 32.83  ? 259 PHE U C    1 
ATOM   1758 O O    . PHE A 1 259 ? 127.379 140.051 115.888 1.00 35.80  ? 259 PHE U O    1 
ATOM   1759 C CB   . PHE A 1 259 ? 129.865 141.894 114.604 1.00 27.52  ? 259 PHE U CB   1 
ATOM   1760 C CG   . PHE A 1 259 ? 129.814 142.290 116.047 1.00 35.62  ? 259 PHE U CG   1 
ATOM   1761 C CD1  . PHE A 1 259 ? 130.472 141.546 117.009 1.00 34.47  ? 259 PHE U CD1  1 
ATOM   1762 C CD2  . PHE A 1 259 ? 129.122 143.423 116.442 1.00 33.15  ? 259 PHE U CD2  1 
ATOM   1763 C CE1  . PHE A 1 259 ? 130.430 141.912 118.337 1.00 33.29  ? 259 PHE U CE1  1 
ATOM   1764 C CE2  . PHE A 1 259 ? 129.076 143.797 117.768 1.00 33.12  ? 259 PHE U CE2  1 
ATOM   1765 C CZ   . PHE A 1 259 ? 129.730 143.040 118.718 1.00 31.31  ? 259 PHE U CZ   1 
ATOM   1766 N N    . ALA A 1 260 ? 126.753 141.445 114.226 1.00 30.49  ? 260 ALA U N    1 
ATOM   1767 C CA   . ALA A 1 260 ? 125.377 141.516 114.706 1.00 28.52  ? 260 ALA U CA   1 
ATOM   1768 C C    . ALA A 1 260 ? 124.676 140.165 114.614 1.00 31.39  ? 260 ALA U C    1 
ATOM   1769 O O    . ALA A 1 260 ? 123.935 139.779 115.526 1.00 40.65  ? 260 ALA U O    1 
ATOM   1770 C CB   . ALA A 1 260 ? 124.604 142.575 113.918 1.00 30.55  ? 260 ALA U CB   1 
ATOM   1771 N N    . ASN A 1 261 ? 124.902 139.429 113.522 1.00 33.60  ? 261 ASN U N    1 
ATOM   1772 C CA   . ASN A 1 261 ? 124.323 138.094 113.383 1.00 36.03  ? 261 ASN U CA   1 
ATOM   1773 C C    . ASN A 1 261 ? 124.805 137.170 114.494 1.00 32.30  ? 261 ASN U C    1 
ATOM   1774 O O    . ASN A 1 261 ? 124.009 136.444 115.112 1.00 36.65  ? 261 ASN U O    1 
ATOM   1775 C CB   . ASN A 1 261 ? 124.674 137.521 112.008 1.00 34.87  ? 261 ASN U CB   1 
ATOM   1776 C CG   . ASN A 1 261 ? 123.868 136.286 111.664 1.00 37.97  ? 261 ASN U CG   1 
ATOM   1777 O OD1  . ASN A 1 261 ? 122.765 136.089 112.167 1.00 46.53  ? 261 ASN U OD1  1 
ATOM   1778 N ND2  . ASN A 1 261 ? 124.419 135.445 110.799 1.00 30.91  ? 261 ASN U ND2  1 
ATOM   1779 N N    . PHE A 1 262 ? 126.111 137.194 114.768 1.00 25.45  ? 262 PHE U N    1 
ATOM   1780 C CA   . PHE A 1 262 ? 126.681 136.376 115.834 1.00 34.45  ? 262 PHE U CA   1 
ATOM   1781 C C    . PHE A 1 262 ? 126.039 136.700 117.176 1.00 37.84  ? 262 PHE U C    1 
ATOM   1782 O O    . PHE A 1 262 ? 125.608 135.798 117.914 1.00 36.19  ? 262 PHE U O    1 
ATOM   1783 C CB   . PHE A 1 262 ? 128.196 136.604 115.879 1.00 30.88  ? 262 PHE U CB   1 
ATOM   1784 C CG   . PHE A 1 262 ? 128.896 135.875 116.985 1.00 35.40  ? 262 PHE U CG   1 
ATOM   1785 C CD1  . PHE A 1 262 ? 129.142 134.516 116.890 1.00 35.00  ? 262 PHE U CD1  1 
ATOM   1786 C CD2  . PHE A 1 262 ? 129.313 136.548 118.120 1.00 34.55  ? 262 PHE U CD2  1 
ATOM   1787 C CE1  . PHE A 1 262 ? 129.791 133.845 117.906 1.00 35.87  ? 262 PHE U CE1  1 
ATOM   1788 C CE2  . PHE A 1 262 ? 129.957 135.883 119.139 1.00 30.14  ? 262 PHE U CE2  1 
ATOM   1789 C CZ   . PHE A 1 262 ? 130.197 134.530 119.033 1.00 31.04  ? 262 PHE U CZ   1 
ATOM   1790 N N    . VAL A 1 263 ? 125.935 137.995 117.497 1.00 36.18  ? 263 VAL U N    1 
ATOM   1791 C CA   . VAL A 1 263 ? 125.386 138.409 118.787 1.00 28.90  ? 263 VAL U CA   1 
ATOM   1792 C C    . VAL A 1 263 ? 123.927 137.975 118.914 1.00 30.61  ? 263 VAL U C    1 
ATOM   1793 O O    . VAL A 1 263 ? 123.506 137.428 119.945 1.00 42.00  ? 263 VAL U O    1 
ATOM   1794 C CB   . VAL A 1 263 ? 125.543 139.929 118.966 1.00 30.61  ? 263 VAL U CB   1 
ATOM   1795 C CG1  . VAL A 1 263 ? 124.696 140.427 120.127 1.00 35.44  ? 263 VAL U CG1  1 
ATOM   1796 C CG2  . VAL A 1 263 ? 127.006 140.291 119.171 1.00 33.56  ? 263 VAL U CG2  1 
ATOM   1797 N N    . PHE A 1 264 ? 123.136 138.214 117.864 1.00 27.62  ? 264 PHE U N    1 
ATOM   1798 C CA   . PHE A 1 264 ? 121.717 137.883 117.914 1.00 25.82  ? 264 PHE U CA   1 
ATOM   1799 C C    . PHE A 1 264 ? 121.502 136.387 118.098 1.00 24.42  ? 264 PHE U C    1 
ATOM   1800 O O    . PHE A 1 264 ? 120.679 135.969 118.927 1.00 32.74  ? 264 PHE U O    1 
ATOM   1801 C CB   . PHE A 1 264 ? 121.015 138.360 116.642 1.00 26.97  ? 264 PHE U CB   1 
ATOM   1802 C CG   . PHE A 1 264 ? 120.614 139.807 116.669 1.00 32.70  ? 264 PHE U CG   1 
ATOM   1803 C CD1  . PHE A 1 264 ? 119.844 140.309 117.704 1.00 33.71  ? 264 PHE U CD1  1 
ATOM   1804 C CD2  . PHE A 1 264 ? 120.985 140.660 115.643 1.00 28.78  ? 264 PHE U CD2  1 
ATOM   1805 C CE1  . PHE A 1 264 ? 119.469 141.636 117.724 1.00 32.63  ? 264 PHE U CE1  1 
ATOM   1806 C CE2  . PHE A 1 264 ? 120.611 141.988 115.658 1.00 29.61  ? 264 PHE U CE2  1 
ATOM   1807 C CZ   . PHE A 1 264 ? 119.852 142.480 116.699 1.00 34.95  ? 264 PHE U CZ   1 
ATOM   1808 N N    . ILE A 1 265 ? 122.243 135.559 117.355 1.00 27.58  ? 265 ILE U N    1 
ATOM   1809 C CA   . ILE A 1 265 ? 122.066 134.117 117.482 1.00 28.73  ? 265 ILE U CA   1 
ATOM   1810 C C    . ILE A 1 265 ? 122.475 133.640 118.872 1.00 31.11  ? 265 ILE U C    1 
ATOM   1811 O O    . ILE A 1 265 ? 121.787 132.807 119.481 1.00 35.91  ? 265 ILE U O    1 
ATOM   1812 C CB   . ILE A 1 265 ? 122.842 133.379 116.375 1.00 30.59  ? 265 ILE U CB   1 
ATOM   1813 C CG1  . ILE A 1 265 ? 122.270 133.734 115.001 1.00 26.43  ? 265 ILE U CG1  1 
ATOM   1814 C CG2  . ILE A 1 265 ? 122.797 131.875 116.593 1.00 28.36  ? 265 ILE U CG2  1 
ATOM   1815 C CD1  . ILE A 1 265 ? 122.865 132.937 113.864 1.00 25.55  ? 265 ILE U CD1  1 
ATOM   1816 N N    . LEU A 1 266 ? 123.574 134.177 119.412 1.00 31.53  ? 266 LEU U N    1 
ATOM   1817 C CA   . LEU A 1 266 ? 124.009 133.776 120.749 1.00 27.00  ? 266 LEU U CA   1 
ATOM   1818 C C    . LEU A 1 266 ? 122.937 134.075 121.797 1.00 31.96  ? 266 LEU U C    1 
ATOM   1819 O O    . LEU A 1 266 ? 122.549 133.193 122.583 1.00 33.24  ? 266 LEU U O    1 
ATOM   1820 C CB   . LEU A 1 266 ? 125.322 134.479 121.092 1.00 28.68  ? 266 LEU U CB   1 
ATOM   1821 C CG   . LEU A 1 266 ? 125.922 134.265 122.484 1.00 33.01  ? 266 LEU U CG   1 
ATOM   1822 C CD1  . LEU A 1 266 ? 126.422 132.841 122.645 1.00 36.93  ? 266 LEU U CD1  1 
ATOM   1823 C CD2  . LEU A 1 266 ? 127.047 135.253 122.727 1.00 26.98  ? 266 LEU U CD2  1 
ATOM   1824 N N    . MET A 1 267 ? 122.429 135.314 121.805 1.00 30.13  ? 267 MET U N    1 
ATOM   1825 C CA   . MET A 1 267 ? 121.419 135.683 122.798 1.00 29.28  ? 267 MET U CA   1 
ATOM   1826 C C    . MET A 1 267 ? 120.137 134.870 122.636 1.00 34.34  ? 267 MET U C    1 
ATOM   1827 O O    . MET A 1 267 ? 119.550 134.420 123.633 1.00 44.49  ? 267 MET U O    1 
ATOM   1828 C CB   . MET A 1 267 ? 121.121 137.182 122.723 1.00 30.05  ? 267 MET U CB   1 
ATOM   1829 C CG   . MET A 1 267 ? 122.362 138.060 122.723 1.00 34.11  ? 267 MET U CG   1 
ATOM   1830 S SD   . MET A 1 267 ? 122.003 139.828 122.727 1.00 59.83  ? 267 MET U SD   1 
ATOM   1831 C CE   . MET A 1 267 ? 120.438 139.868 121.865 1.00 40.03  ? 267 MET U CE   1 
ATOM   1832 N N    . GLY A 1 268 ? 119.687 134.668 121.394 1.00 27.15  ? 268 GLY U N    1 
ATOM   1833 C CA   . GLY A 1 268 ? 118.475 133.898 121.182 1.00 23.27  ? 268 GLY U CA   1 
ATOM   1834 C C    . GLY A 1 268 ? 118.595 132.462 121.655 1.00 22.51  ? 268 GLY U C    1 
ATOM   1835 O O    . GLY A 1 268 ? 117.677 131.928 122.294 1.00 27.32  ? 268 GLY U O    1 
ATOM   1836 N N    . VAL A 1 269 ? 119.734 131.823 121.372 1.00 25.89  ? 269 VAL U N    1 
ATOM   1837 C CA   . VAL A 1 269 ? 119.928 130.442 121.805 1.00 27.69  ? 269 VAL U CA   1 
ATOM   1838 C C    . VAL A 1 269 ? 119.930 130.353 123.326 1.00 33.47  ? 269 VAL U C    1 
ATOM   1839 O O    . VAL A 1 269 ? 119.298 129.460 123.909 1.00 43.49  ? 269 VAL U O    1 
ATOM   1840 C CB   . VAL A 1 269 ? 121.219 129.862 121.195 1.00 32.53  ? 269 VAL U CB   1 
ATOM   1841 C CG1  . VAL A 1 269 ? 121.552 128.527 121.831 1.00 31.42  ? 269 VAL U CG1  1 
ATOM   1842 C CG2  . VAL A 1 269 ? 121.062 129.696 119.693 1.00 33.56  ? 269 VAL U CG2  1 
ATOM   1843 N N    . CYS A 1 270 ? 120.616 131.287 123.993 1.00 37.75  ? 270 CYS U N    1 
ATOM   1844 C CA   . CYS A 1 270 ? 120.619 131.285 125.456 1.00 33.16  ? 270 CYS U CA   1 
ATOM   1845 C C    . CYS A 1 270 ? 119.202 131.401 126.020 1.00 33.05  ? 270 CYS U C    1 
ATOM   1846 O O    . CYS A 1 270 ? 118.791 130.613 126.893 1.00 42.27  ? 270 CYS U O    1 
ATOM   1847 C CB   . CYS A 1 270 ? 121.501 132.422 125.975 1.00 30.30  ? 270 CYS U CB   1 
ATOM   1848 S SG   . CYS A 1 270 ? 123.263 132.220 125.628 1.00 52.44  ? 270 CYS U SG   1 
ATOM   1849 N N    . CYS A 1 271 ? 118.433 132.375 125.520 1.00 26.24  ? 271 CYS U N    1 
ATOM   1850 C CA   . CYS A 1 271 ? 117.097 132.614 126.060 1.00 27.48  ? 271 CYS U CA   1 
ATOM   1851 C C    . CYS A 1 271 ? 116.181 131.413 125.836 1.00 33.18  ? 271 CYS U C    1 
ATOM   1852 O O    . CYS A 1 271 ? 115.433 131.012 126.743 1.00 39.58  ? 271 CYS U O    1 
ATOM   1853 C CB   . CYS A 1 271 ? 116.498 133.875 125.439 1.00 30.99  ? 271 CYS U CB   1 
ATOM   1854 S SG   . CYS A 1 271 ? 117.331 135.399 125.933 1.00 57.96  ? 271 CYS U SG   1 
ATOM   1855 N N    . ILE A 1 272 ? 116.236 130.809 124.647 1.00 30.03  ? 272 ILE U N    1 
ATOM   1856 C CA   . ILE A 1 272 ? 115.338 129.695 124.354 1.00 30.38  ? 272 ILE U CA   1 
ATOM   1857 C C    . ILE A 1 272 ? 115.722 128.464 125.170 1.00 33.66  ? 272 ILE U C    1 
ATOM   1858 O O    . ILE A 1 272 ? 114.852 127.711 125.627 1.00 36.62  ? 272 ILE U O    1 
ATOM   1859 C CB   . ILE A 1 272 ? 115.323 129.406 122.844 1.00 32.79  ? 272 ILE U CB   1 
ATOM   1860 C CG1  . ILE A 1 272 ? 114.680 130.577 122.101 1.00 29.52  ? 272 ILE U CG1  1 
ATOM   1861 C CG2  . ILE A 1 272 ? 114.579 128.112 122.548 1.00 26.74  ? 272 ILE U CG2  1 
ATOM   1862 C CD1  . ILE A 1 272 ? 113.224 130.787 122.438 1.00 27.59  ? 272 ILE U CD1  1 
ATOM   1863 N N    . ALA A 1 273 ? 117.022 128.245 125.383 1.00 33.64  ? 273 ALA U N    1 
ATOM   1864 C CA   . ALA A 1 273 ? 117.463 127.145 126.236 1.00 31.65  ? 273 ALA U CA   1 
ATOM   1865 C C    . ALA A 1 273 ? 116.906 127.294 127.650 1.00 36.63  ? 273 ALA U C    1 
ATOM   1866 O O    . ALA A 1 273 ? 116.360 126.336 128.231 1.00 39.18  ? 273 ALA U O    1 
ATOM   1867 C CB   . ALA A 1 273 ? 118.982 127.071 126.266 1.00 30.00  ? 273 ALA U CB   1 
ATOM   1868 N N    . SER A 1 274 ? 117.016 128.498 128.218 1.00 33.18  ? 274 SER U N    1 
ATOM   1869 C CA   . SER A 1 274 ? 116.480 128.722 129.561 1.00 31.95  ? 274 SER U CA   1 
ATOM   1870 C C    . SER A 1 274 ? 114.966 128.512 129.608 1.00 33.97  ? 274 SER U C    1 
ATOM   1871 O O    . SER A 1 274 ? 114.438 127.901 130.556 1.00 42.97  ? 274 SER U O    1 
ATOM   1872 C CB   . SER A 1 274 ? 116.839 130.131 130.029 1.00 36.30  ? 274 SER U CB   1 
ATOM   1873 O OG   . SER A 1 274 ? 118.222 130.386 129.853 1.00 37.90  ? 274 SER U OG   1 
ATOM   1874 N N    . LEU A 1 275 ? 114.253 128.999 128.588 1.00 30.34  ? 275 LEU U N    1 
ATOM   1875 C CA   . LEU A 1 275 ? 112.803 128.836 128.557 1.00 33.18  ? 275 LEU U CA   1 
ATOM   1876 C C    . LEU A 1 275 ? 112.411 127.364 128.508 1.00 35.96  ? 275 LEU U C    1 
ATOM   1877 O O    . LEU A 1 275 ? 111.475 126.937 129.202 1.00 36.83  ? 275 LEU U O    1 
ATOM   1878 C CB   . LEU A 1 275 ? 112.218 129.590 127.363 1.00 29.46  ? 275 LEU U CB   1 
ATOM   1879 C CG   . LEU A 1 275 ? 110.693 129.592 127.253 1.00 32.53  ? 275 LEU U CG   1 
ATOM   1880 C CD1  . LEU A 1 275 ? 110.076 130.203 128.501 1.00 31.46  ? 275 LEU U CD1  1 
ATOM   1881 C CD2  . LEU A 1 275 ? 110.236 130.331 126.012 1.00 33.34  ? 275 LEU U CD2  1 
ATOM   1882 N N    . PHE A 1 276 ? 113.120 126.573 127.699 1.00 33.72  ? 276 PHE U N    1 
ATOM   1883 C CA   . PHE A 1 276 ? 112.827 125.147 127.608 1.00 23.36  ? 276 PHE U CA   1 
ATOM   1884 C C    . PHE A 1 276 ? 113.054 124.446 128.941 1.00 25.68  ? 276 PHE U C    1 
ATOM   1885 O O    . PHE A 1 276 ? 112.256 123.583 129.338 1.00 31.01  ? 276 PHE U O    1 
ATOM   1886 C CB   . PHE A 1 276 ? 113.669 124.498 126.509 1.00 23.56  ? 276 PHE U CB   1 
ATOM   1887 C CG   . PHE A 1 276 ? 113.126 124.709 125.124 1.00 31.77  ? 276 PHE U CG   1 
ATOM   1888 C CD1  . PHE A 1 276 ? 111.958 125.426 124.921 1.00 31.35  ? 276 PHE U CD1  1 
ATOM   1889 C CD2  . PHE A 1 276 ? 113.776 124.177 124.026 1.00 27.95  ? 276 PHE U CD2  1 
ATOM   1890 C CE1  . PHE A 1 276 ? 111.457 125.617 123.648 1.00 24.95  ? 276 PHE U CE1  1 
ATOM   1891 C CE2  . PHE A 1 276 ? 113.280 124.361 122.751 1.00 26.04  ? 276 PHE U CE2  1 
ATOM   1892 C CZ   . PHE A 1 276 ? 112.119 125.082 122.562 1.00 22.27  ? 276 PHE U CZ   1 
ATOM   1893 N N    . ASN A 1 277 ? 114.128 124.799 129.655 1.00 31.70  ? 277 ASN U N    1 
ATOM   1894 C CA   . ASN A 1 277 ? 114.359 124.173 130.958 1.00 26.26  ? 277 ASN U CA   1 
ATOM   1895 C C    . ASN A 1 277 ? 113.231 124.493 131.940 1.00 31.12  ? 277 ASN U C    1 
ATOM   1896 O O    . ASN A 1 277 ? 112.741 123.603 132.662 1.00 41.23  ? 277 ASN U O    1 
ATOM   1897 C CB   . ASN A 1 277 ? 115.705 124.621 131.525 1.00 27.73  ? 277 ASN U CB   1 
ATOM   1898 C CG   . ASN A 1 277 ? 116.883 123.936 130.853 1.00 36.76  ? 277 ASN U CG   1 
ATOM   1899 O OD1  . ASN A 1 277 ? 116.743 123.341 129.785 1.00 30.73  ? 277 ASN U OD1  1 
ATOM   1900 N ND2  . ASN A 1 277 ? 118.046 124.010 131.484 1.00 39.65  ? 277 ASN U ND2  1 
ATOM   1901 N N    . VAL A 1 278 ? 112.788 125.752 131.972 1.00 31.00  ? 278 VAL U N    1 
ATOM   1902 C CA   . VAL A 1 278 ? 111.704 126.124 132.886 1.00 29.92  ? 278 VAL U CA   1 
ATOM   1903 C C    . VAL A 1 278 ? 110.413 125.383 132.530 1.00 34.50  ? 278 VAL U C    1 
ATOM   1904 O O    . VAL A 1 278 ? 109.691 124.885 133.417 1.00 39.75  ? 278 VAL U O    1 
ATOM   1905 C CB   . VAL A 1 278 ? 111.508 127.651 132.880 1.00 35.59  ? 278 VAL U CB   1 
ATOM   1906 C CG1  . VAL A 1 278 ? 110.268 128.034 133.660 1.00 37.34  ? 278 VAL U CG1  1 
ATOM   1907 C CG2  . VAL A 1 278 ? 112.733 128.336 133.458 1.00 32.90  ? 278 VAL U CG2  1 
ATOM   1908 N N    . ILE A 1 279 ? 110.104 125.282 131.235 1.00 33.11  ? 279 ILE U N    1 
ATOM   1909 C CA   . ILE A 1 279 ? 108.887 124.587 130.823 1.00 30.18  ? 279 ILE U CA   1 
ATOM   1910 C C    . ILE A 1 279 ? 108.965 123.103 131.182 1.00 33.54  ? 279 ILE U C    1 
ATOM   1911 O O    . ILE A 1 279 ? 107.960 122.490 131.559 1.00 39.82  ? 279 ILE U O    1 
ATOM   1912 C CB   . ILE A 1 279 ? 108.630 124.795 129.320 1.00 30.85  ? 279 ILE U CB   1 
ATOM   1913 C CG1  . ILE A 1 279 ? 108.227 126.243 129.045 1.00 29.39  ? 279 ILE U CG1  1 
ATOM   1914 C CG2  . ILE A 1 279 ? 107.530 123.871 128.826 1.00 31.91  ? 279 ILE U CG2  1 
ATOM   1915 C CD1  . ILE A 1 279 ? 108.339 126.635 127.590 1.00 29.90  ? 279 ILE U CD1  1 
ATOM   1916 N N    . SER A 1 280 ? 110.160 122.510 131.095 1.00 31.90  ? 280 SER U N    1 
ATOM   1917 C CA   . SER A 1 280 ? 110.320 121.116 131.504 1.00 26.33  ? 280 SER U CA   1 
ATOM   1918 C C    . SER A 1 280 ? 110.032 120.936 132.991 1.00 28.85  ? 280 SER U C    1 
ATOM   1919 O O    . SER A 1 280 ? 109.397 119.950 133.396 1.00 35.94  ? 280 SER U O    1 
ATOM   1920 C CB   . SER A 1 280 ? 111.726 120.627 131.167 1.00 26.44  ? 280 SER U CB   1 
ATOM   1921 O OG   . SER A 1 280 ? 112.698 121.267 131.975 1.00 37.64  ? 280 SER U OG   1 
ATOM   1922 N N    . ILE A 1 281 ? 110.485 121.880 133.819 1.00 34.01  ? 281 ILE U N    1 
ATOM   1923 C CA   . ILE A 1 281 ? 110.177 121.806 135.250 1.00 36.49  ? 281 ILE U CA   1 
ATOM   1924 C C    . ILE A 1 281 ? 108.666 121.851 135.482 1.00 39.12  ? 281 ILE U C    1 
ATOM   1925 O O    . ILE A 1 281 ? 108.108 121.060 136.265 1.00 45.06  ? 281 ILE U O    1 
ATOM   1926 C CB   . ILE A 1 281 ? 110.898 122.937 136.010 1.00 34.52  ? 281 ILE U CB   1 
ATOM   1927 C CG1  . ILE A 1 281 ? 112.410 122.715 135.979 1.00 33.30  ? 281 ILE U CG1  1 
ATOM   1928 C CG2  . ILE A 1 281 ? 110.402 123.024 137.442 1.00 36.29  ? 281 ILE U CG2  1 
ATOM   1929 C CD1  . ILE A 1 281 ? 113.194 123.789 136.698 1.00 38.51  ? 281 ILE U CD1  1 
ATOM   1930 N N    . LEU A 1 282 ? 107.979 122.759 134.785 1.00 34.37  ? 282 LEU U N    1 
ATOM   1931 C CA   . LEU A 1 282 ? 106.527 122.857 134.940 1.00 34.27  ? 282 LEU U CA   1 
ATOM   1932 C C    . LEU A 1 282 ? 105.825 121.576 134.487 1.00 35.90  ? 282 LEU U C    1 
ATOM   1933 O O    . LEU A 1 282 ? 104.852 121.132 135.116 1.00 40.05  ? 282 LEU U O    1 
ATOM   1934 C CB   . LEU A 1 282 ? 106.001 124.065 134.168 1.00 37.89  ? 282 LEU U CB   1 
ATOM   1935 C CG   . LEU A 1 282 ? 106.229 125.428 134.825 1.00 38.13  ? 282 LEU U CG   1 
ATOM   1936 C CD1  . LEU A 1 282 ? 105.632 126.541 133.982 1.00 38.26  ? 282 LEU U CD1  1 
ATOM   1937 C CD2  . LEU A 1 282 ? 105.659 125.453 136.233 1.00 34.87  ? 282 LEU U CD2  1 
ATOM   1938 N N    . ILE A 1 283 ? 106.307 120.969 133.401 1.00 34.30  ? 283 ILE U N    1 
ATOM   1939 C CA   . ILE A 1 283 ? 105.709 119.728 132.912 1.00 31.79  ? 283 ILE U CA   1 
ATOM   1940 C C    . ILE A 1 283 ? 105.891 118.604 133.923 1.00 33.56  ? 283 ILE U C    1 
ATOM   1941 O O    . ILE A 1 283 ? 104.989 117.779 134.125 1.00 36.65  ? 283 ILE U O    1 
ATOM   1942 C CB   . ILE A 1 283 ? 106.299 119.356 131.537 1.00 30.50  ? 283 ILE U CB   1 
ATOM   1943 C CG1  . ILE A 1 283 ? 105.811 120.329 130.465 1.00 34.46  ? 283 ILE U CG1  1 
ATOM   1944 C CG2  . ILE A 1 283 ? 105.935 117.928 131.160 1.00 29.01  ? 283 ILE U CG2  1 
ATOM   1945 C CD1  . ILE A 1 283 ? 106.295 119.996 129.077 1.00 31.06  ? 283 ILE U CD1  1 
ATOM   1946 N N    . LYS A 1 284 ? 107.052 118.549 134.581 1.00 34.26  ? 284 LYS U N    1 
ATOM   1947 C CA   . LYS A 1 284 ? 107.248 117.536 135.617 1.00 32.78  ? 284 LYS U CA   1 
ATOM   1948 C C    . LYS A 1 284 ? 106.267 117.729 136.769 1.00 33.16  ? 284 LYS U C    1 
ATOM   1949 O O    . LYS A 1 284 ? 105.709 116.753 137.295 1.00 35.89  ? 284 LYS U O    1 
ATOM   1950 C CB   . LYS A 1 284 ? 108.688 117.572 136.131 1.00 31.24  ? 284 LYS U CB   1 
ATOM   1951 C CG   . LYS A 1 284 ? 109.004 116.461 137.120 1.00 30.46  ? 284 LYS U CG   1 
ATOM   1952 C CD   . LYS A 1 284 ? 110.145 116.848 138.045 1.00 35.64  ? 284 LYS U CD   1 
ATOM   1953 C CE   . LYS A 1 284 ? 110.613 115.660 138.873 1.00 37.02  ? 284 LYS U CE   1 
ATOM   1954 N NZ   . LYS A 1 284 ? 111.179 114.578 138.022 1.00 38.79  ? 284 LYS U NZ   1 
ATOM   1955 N N    . GLN A 1 285 ? 106.037 118.984 137.173 1.00 40.07  ? 285 GLN U N    1 
ATOM   1956 C CA   . GLN A 1 285 ? 105.042 119.235 138.220 1.00 38.02  ? 285 GLN U CA   1 
ATOM   1957 C C    . GLN A 1 285 ? 103.648 118.772 137.786 1.00 40.15  ? 285 GLN U C    1 
ATOM   1958 O O    . GLN A 1 285 ? 102.903 118.181 138.580 1.00 40.31  ? 285 GLN U O    1 
ATOM   1959 C CB   . GLN A 1 285 ? 105.024 120.712 138.602 1.00 39.53  ? 285 GLN U CB   1 
ATOM   1960 C CG   . GLN A 1 285 ? 106.301 121.189 139.272 1.00 45.74  ? 285 GLN U CG   1 
ATOM   1961 C CD   . GLN A 1 285 ? 106.112 122.495 140.016 1.00 53.13  ? 285 GLN U CD   1 
ATOM   1962 O OE1  . GLN A 1 285 ? 105.034 123.089 139.989 1.00 53.38  ? 285 GLN U OE1  1 
ATOM   1963 N NE2  . GLN A 1 285 ? 107.165 122.949 140.688 1.00 50.85  ? 285 GLN U NE2  1 
ATOM   1964 N N    . SER A 1 286 ? 103.283 119.032 136.528 1.00 42.63  ? 286 SER U N    1 
ATOM   1965 C CA   . SER A 1 286 ? 101.973 118.597 136.045 1.00 35.71  ? 286 SER U CA   1 
ATOM   1966 C C    . SER A 1 286 ? 101.861 117.076 136.037 1.00 40.11  ? 286 SER U C    1 
ATOM   1967 O O    . SER A 1 286 ? 100.799 116.521 136.353 1.00 45.87  ? 286 SER U O    1 
ATOM   1968 C CB   . SER A 1 286 ? 101.707 119.159 134.647 1.00 38.74  ? 286 SER U CB   1 
ATOM   1969 O OG   . SER A 1 286 ? 102.722 118.767 133.740 1.00 44.59  ? 286 SER U OG   1 
ATOM   1970 N N    . LEU A 1 287 ? 102.941 116.387 135.659 1.00 42.53  ? 287 LEU U N    1 
ATOM   1971 C CA   . LEU A 1 287 ? 102.942 114.926 135.703 1.00 34.65  ? 287 LEU U CA   1 
ATOM   1972 C C    . LEU A 1 287 ? 102.728 114.416 137.122 1.00 38.65  ? 287 LEU U C    1 
ATOM   1973 O O    . LEU A 1 287 ? 101.973 113.459 137.346 1.00 42.45  ? 287 LEU U O    1 
ATOM   1974 C CB   . LEU A 1 287 ? 104.252 114.376 135.138 1.00 38.47  ? 287 LEU U CB   1 
ATOM   1975 C CG   . LEU A 1 287 ? 104.400 114.363 133.618 1.00 39.03  ? 287 LEU U CG   1 
ATOM   1976 C CD1  . LEU A 1 287 ? 105.739 113.761 133.232 1.00 36.26  ? 287 LEU U CD1  1 
ATOM   1977 C CD2  . LEU A 1 287 ? 103.258 113.593 132.978 1.00 39.31  ? 287 LEU U CD2  1 
ATOM   1978 N N    . ASN A 1 288 ? 103.392 115.038 138.099 1.00 47.74  ? 288 ASN U N    1 
ATOM   1979 C CA   . ASN A 1 288 ? 103.158 114.658 139.490 1.00 42.28  ? 288 ASN U CA   1 
ATOM   1980 C C    . ASN A 1 288 ? 101.695 114.851 139.879 1.00 46.41  ? 288 ASN U C    1 
ATOM   1981 O O    . ASN A 1 288 ? 101.100 113.996 140.555 1.00 49.43  ? 288 ASN U O    1 
ATOM   1982 C CB   . ASN A 1 288 ? 104.074 115.454 140.417 1.00 43.58  ? 288 ASN U CB   1 
ATOM   1983 C CG   . ASN A 1 288 ? 105.427 114.802 140.604 1.00 48.58  ? 288 ASN U CG   1 
ATOM   1984 O OD1  . ASN A 1 288 ? 105.540 113.576 140.617 1.00 56.62  ? 288 ASN U OD1  1 
ATOM   1985 N ND2  . ASN A 1 288 ? 106.461 115.618 140.764 1.00 47.84  ? 288 ASN U ND2  1 
ATOM   1986 N N    . TRP A 1 289 ? 101.093 115.966 139.452 1.00 52.22  ? 289 TRP U N    1 
ATOM   1987 C CA   . TRP A 1 289 ? 99.693  116.224 139.790 1.00 50.77  ? 289 TRP U CA   1 
ATOM   1988 C C    . TRP A 1 289 ? 98.773  115.158 139.199 1.00 51.24  ? 289 TRP U C    1 
ATOM   1989 O O    . TRP A 1 289 ? 97.882  114.639 139.887 1.00 57.22  ? 289 TRP U O    1 
ATOM   1990 C CB   . TRP A 1 289 ? 99.276  117.611 139.302 1.00 54.38  ? 289 TRP U CB   1 
ATOM   1991 C CG   . TRP A 1 289 ? 97.836  117.920 139.588 1.00 56.97  ? 289 TRP U CG   1 
ATOM   1992 C CD1  . TRP A 1 289 ? 97.311  118.353 140.770 1.00 54.41  ? 289 TRP U CD1  1 
ATOM   1993 C CD2  . TRP A 1 289 ? 96.734  117.793 138.683 1.00 57.19  ? 289 TRP U CD2  1 
ATOM   1994 N NE1  . TRP A 1 289 ? 95.952  118.515 140.653 1.00 50.74  ? 289 TRP U NE1  1 
ATOM   1995 C CE2  . TRP A 1 289 ? 95.573  118.177 139.381 1.00 53.52  ? 289 TRP U CE2  1 
ATOM   1996 C CE3  . TRP A 1 289 ? 96.615  117.398 137.347 1.00 56.19  ? 289 TRP U CE3  1 
ATOM   1997 C CZ2  . TRP A 1 289 ? 94.311  118.179 138.792 1.00 53.77  ? 289 TRP U CZ2  1 
ATOM   1998 C CZ3  . TRP A 1 289 ? 95.361  117.401 136.762 1.00 55.36  ? 289 TRP U CZ3  1 
ATOM   1999 C CH2  . TRP A 1 289 ? 94.226  117.787 137.483 1.00 54.18  ? 289 TRP U CH2  1 
ATOM   2000 N N    . ILE A 1 290 ? 98.985  114.804 137.927 1.00 53.57  ? 290 ILE U N    1 
ATOM   2001 C CA   . ILE A 1 290 ? 98.087  113.830 137.308 1.00 54.34  ? 290 ILE U CA   1 
ATOM   2002 C C    . ILE A 1 290 ? 98.294  112.460 137.944 1.00 54.30  ? 290 ILE U C    1 
ATOM   2003 O O    . ILE A 1 290 ? 97.334  111.693 138.101 1.00 54.95  ? 290 ILE U O    1 
ATOM   2004 C CB   . ILE A 1 290 ? 98.245  113.787 135.771 1.00 51.85  ? 290 ILE U CB   1 
ATOM   2005 C CG1  . ILE A 1 290 ? 97.583  112.539 135.186 1.00 52.64  ? 290 ILE U CG1  1 
ATOM   2006 C CG2  . ILE A 1 290 ? 99.682  113.781 135.363 1.00 52.91  ? 290 ILE U CG2  1 
ATOM   2007 C CD1  . ILE A 1 290 ? 97.625  112.485 133.677 1.00 56.16  ? 290 ILE U CD1  1 
ATOM   2008 N N    . LEU A 1 291 ? 99.529  112.126 138.336 1.00 57.50  ? 291 LEU U N    1 
ATOM   2009 C CA   . LEU A 1 291 ? 99.737  110.868 139.047 1.00 53.44  ? 291 LEU U CA   1 
ATOM   2010 C C    . LEU A 1 291 ? 98.949  110.855 140.352 1.00 53.17  ? 291 LEU U C    1 
ATOM   2011 O O    . LEU A 1 291 ? 98.289  109.862 140.678 1.00 53.50  ? 291 LEU U O    1 
ATOM   2012 C CB   . LEU A 1 291 ? 101.223 110.639 139.316 1.00 50.12  ? 291 LEU U CB   1 
ATOM   2013 C CG   . LEU A 1 291 ? 102.076 110.132 138.156 1.00 49.00  ? 291 LEU U CG   1 
ATOM   2014 C CD1  . LEU A 1 291 ? 103.416 109.642 138.668 1.00 52.82  ? 291 LEU U CD1  1 
ATOM   2015 C CD2  . LEU A 1 291 ? 101.344 109.010 137.447 1.00 49.90  ? 291 LEU U CD2  1 
ATOM   2016 N N    . ARG A 1 292 ? 99.016  111.947 141.122 1.00 66.45  ? 292 ARG U N    1 
ATOM   2017 C CA   . ARG A 1 292 ? 98.259  112.007 142.370 1.00 66.97  ? 292 ARG U CA   1 
ATOM   2018 C C    . ARG A 1 292 ? 96.765  111.810 142.127 1.00 67.13  ? 292 ARG U C    1 
ATOM   2019 O O    . ARG A 1 292 ? 96.105  111.045 142.839 1.00 66.29  ? 292 ARG U O    1 
ATOM   2020 C CB   . ARG A 1 292 ? 98.496  113.315 143.128 1.00 67.43  ? 292 ARG U CB   1 
ATOM   2021 C CG   . ARG A 1 292 ? 99.886  113.525 143.696 1.00 68.69  ? 292 ARG U CG   1 
ATOM   2022 C CD   . ARG A 1 292 ? 99.961  114.883 144.386 1.00 69.98  ? 292 ARG U CD   1 
ATOM   2023 N NE   . ARG A 1 292 ? 101.263 115.151 144.988 1.00 72.56  ? 292 ARG U NE   1 
ATOM   2024 C CZ   . ARG A 1 292 ? 102.312 115.626 144.330 1.00 72.50  ? 292 ARG U CZ   1 
ATOM   2025 N NH1  . ARG A 1 292 ? 102.336 115.668 143.011 1.00 70.25  ? 292 ARG U NH1  1 
ATOM   2026 N NH2  . ARG A 1 292 ? 103.393 115.993 145.013 1.00 71.29  ? 292 ARG U NH2  1 
ATOM   2027 N N    . LYS A 1 293 ? 96.211  112.511 141.133 1.00 74.21  ? 293 LYS U N    1 
ATOM   2028 C CA   . LYS A 1 293 ? 94.770  112.421 140.885 1.00 76.45  ? 293 LYS U CA   1 
ATOM   2029 C C    . LYS A 1 293 ? 94.324  111.006 140.533 1.00 74.85  ? 293 LYS U C    1 
ATOM   2030 O O    . LYS A 1 293 ? 93.268  110.554 140.989 1.00 75.63  ? 293 LYS U O    1 
ATOM   2031 C CB   . LYS A 1 293 ? 94.364  113.394 139.777 1.00 75.65  ? 293 LYS U CB   1 
ATOM   2032 C CG   . LYS A 1 293 ? 92.879  113.352 139.443 1.00 74.29  ? 293 LYS U CG   1 
ATOM   2033 C CD   . LYS A 1 293 ? 92.022  113.731 140.642 1.00 75.20  ? 293 LYS U CD   1 
ATOM   2034 C CE   . LYS A 1 293 ? 92.238  115.176 141.049 1.00 74.80  ? 293 LYS U CE   1 
ATOM   2035 N NZ   . LYS A 1 293 ? 91.813  116.111 139.972 1.00 74.40  ? 293 LYS U NZ   1 
ATOM   2036 N N    . MET A 1 294 ? 95.106  110.285 139.726 1.00 79.04  ? 294 MET U N    1 
ATOM   2037 C CA   . MET A 1 294 ? 94.685  108.953 139.295 1.00 78.48  ? 294 MET U CA   1 
ATOM   2038 C C    . MET A 1 294 ? 94.646  107.931 140.424 1.00 81.12  ? 294 MET U C    1 
ATOM   2039 O O    . MET A 1 294 ? 94.151  106.820 140.201 1.00 81.15  ? 294 MET U O    1 
ATOM   2040 C CB   . MET A 1 294 ? 95.588  108.438 138.174 1.00 78.22  ? 294 MET U CB   1 
ATOM   2041 C CG   . MET A 1 294 ? 95.277  109.031 136.811 1.00 79.35  ? 294 MET U CG   1 
ATOM   2042 S SD   . MET A 1 294 ? 96.614  108.802 135.625 1.00 87.35  ? 294 MET U SD   1 
ATOM   2043 C CE   . MET A 1 294 ? 96.182  107.207 134.938 1.00 79.35  ? 294 MET U CE   1 
ATOM   2044 N N    . ASP A 1 295 ? 95.134  108.273 141.615 1.00 86.56  ? 295 ASP U N    1 
ATOM   2045 C CA   . ASP A 1 295 ? 95.240  107.329 142.732 1.00 84.90  ? 295 ASP U CA   1 
ATOM   2046 C C    . ASP A 1 295 ? 95.919  106.026 142.320 1.00 85.95  ? 295 ASP U C    1 
ATOM   2047 O O    . ASP A 1 295 ? 96.483  105.318 143.155 1.00 87.11  ? 295 ASP U O    1 
ATOM   2048 C CB   . ASP A 1 295 ? 93.855  107.027 143.316 1.00 84.81  ? 295 ASP U CB   1 
ATOM   2049 C CG   . ASP A 1 295 ? 93.209  108.244 143.951 1.00 87.99  ? 295 ASP U CG   1 
ATOM   2050 O OD1  . ASP A 1 295 ? 93.820  109.334 143.912 1.00 88.12  ? 295 ASP U OD1  1 
ATOM   2051 O OD2  . ASP A 1 295 ? 92.091  108.112 144.489 1.00 87.78  ? 295 ASP U OD2  1 
ATOM   2052 N N    . ASN B 1 14  ? 132.136 137.548 143.192 1.00 48.19  ? 14  ASN A N    1 
ATOM   2053 C CA   . ASN B 1 14  ? 133.168 137.862 142.211 1.00 50.98  ? 14  ASN A CA   1 
ATOM   2054 C C    . ASN B 1 14  ? 133.734 136.594 141.580 1.00 54.03  ? 14  ASN A C    1 
ATOM   2055 O O    . ASN B 1 14  ? 134.272 136.629 140.474 1.00 58.54  ? 14  ASN A O    1 
ATOM   2056 C CB   . ASN B 1 14  ? 134.292 138.673 142.861 1.00 50.72  ? 14  ASN A CB   1 
ATOM   2057 C CG   . ASN B 1 14  ? 135.197 139.334 141.841 1.00 51.34  ? 14  ASN A CG   1 
ATOM   2058 O OD1  . ASN B 1 14  ? 134.844 139.469 140.669 1.00 55.08  ? 14  ASN A OD1  1 
ATOM   2059 N ND2  . ASN B 1 14  ? 136.377 139.755 142.283 1.00 50.28  ? 14  ASN A ND2  1 
ATOM   2060 N N    . GLU B 1 15  ? 133.599 135.474 142.292 1.00 52.60  ? 15  GLU A N    1 
ATOM   2061 C CA   . GLU B 1 15  ? 134.044 134.196 141.748 1.00 51.84  ? 15  GLU A CA   1 
ATOM   2062 C C    . GLU B 1 15  ? 133.202 133.770 140.551 1.00 57.36  ? 15  GLU A C    1 
ATOM   2063 O O    . GLU B 1 15  ? 133.737 133.271 139.554 1.00 60.40  ? 15  GLU A O    1 
ATOM   2064 C CB   . GLU B 1 15  ? 134.008 133.127 142.838 1.00 51.79  ? 15  GLU A CB   1 
ATOM   2065 C CG   . GLU B 1 15  ? 134.483 131.756 142.390 1.00 58.41  ? 15  GLU A CG   1 
ATOM   2066 C CD   . GLU B 1 15  ? 134.606 130.777 143.541 1.00 66.22  ? 15  GLU A CD   1 
ATOM   2067 O OE1  . GLU B 1 15  ? 134.503 131.214 144.708 1.00 64.16  ? 15  GLU A OE1  1 
ATOM   2068 O OE2  . GLU B 1 15  ? 134.810 129.574 143.282 1.00 65.21  ? 15  GLU A OE2  1 
ATOM   2069 N N    . ASP B 1 16  ? 131.882 133.958 140.631 1.00 49.00  ? 16  ASP A N    1 
ATOM   2070 C CA   . ASP B 1 16  ? 131.012 133.575 139.523 1.00 45.43  ? 16  ASP A CA   1 
ATOM   2071 C C    . ASP B 1 16  ? 131.287 134.412 138.280 1.00 50.47  ? 16  ASP A C    1 
ATOM   2072 O O    . ASP B 1 16  ? 131.325 133.881 137.162 1.00 54.53  ? 16  ASP A O    1 
ATOM   2073 C CB   . ASP B 1 16  ? 129.547 133.703 139.942 1.00 48.88  ? 16  ASP A CB   1 
ATOM   2074 C CG   . ASP B 1 16  ? 129.213 132.848 141.149 1.00 55.57  ? 16  ASP A CG   1 
ATOM   2075 O OD1  . ASP B 1 16  ? 129.843 131.784 141.320 1.00 59.75  ? 16  ASP A OD1  1 
ATOM   2076 O OD2  . ASP B 1 16  ? 128.319 133.243 141.927 1.00 55.64  ? 16  ASP A OD2  1 
ATOM   2077 N N    . ASN B 1 17  ? 131.480 135.723 138.450 1.00 42.62  ? 17  ASN A N    1 
ATOM   2078 C CA   . ASN B 1 17  ? 131.798 136.579 137.312 1.00 44.43  ? 17  ASN A CA   1 
ATOM   2079 C C    . ASN B 1 17  ? 133.137 136.199 136.690 1.00 46.79  ? 17  ASN A C    1 
ATOM   2080 O O    . ASN B 1 17  ? 133.275 136.167 135.459 1.00 49.39  ? 17  ASN A O    1 
ATOM   2081 C CB   . ASN B 1 17  ? 131.805 138.044 137.745 1.00 47.08  ? 17  ASN A CB   1 
ATOM   2082 C CG   . ASN B 1 17  ? 130.483 138.484 138.340 1.00 50.07  ? 17  ASN A CG   1 
ATOM   2083 O OD1  . ASN B 1 17  ? 129.443 137.877 138.090 1.00 50.59  ? 17  ASN A OD1  1 
ATOM   2084 N ND2  . ASN B 1 17  ? 130.518 139.546 139.133 1.00 50.71  ? 17  ASN A ND2  1 
ATOM   2085 N N    . ALA B 1 18  ? 134.134 135.911 137.528 1.00 37.50  ? 18  ALA A N    1 
ATOM   2086 C CA   . ALA B 1 18  ? 135.439 135.498 137.015 1.00 37.22  ? 18  ALA A CA   1 
ATOM   2087 C C    . ALA B 1 18  ? 135.336 134.191 136.244 1.00 38.95  ? 18  ALA A C    1 
ATOM   2088 O O    . ALA B 1 18  ? 135.949 134.039 135.182 1.00 41.68  ? 18  ALA A O    1 
ATOM   2089 C CB   . ALA B 1 18  ? 136.437 135.371 138.164 1.00 35.46  ? 18  ALA A CB   1 
ATOM   2090 N N    . ARG B 1 19  ? 134.568 133.234 136.767 1.00 33.18  ? 19  ARG A N    1 
ATOM   2091 C CA   . ARG B 1 19  ? 134.385 131.962 136.072 1.00 30.81  ? 19  ARG A CA   1 
ATOM   2092 C C    . ARG B 1 19  ? 133.681 132.159 134.735 1.00 34.41  ? 19  ARG A C    1 
ATOM   2093 O O    . ARG B 1 19  ? 134.071 131.562 133.723 1.00 43.26  ? 19  ARG A O    1 
ATOM   2094 C CB   . ARG B 1 19  ? 133.600 131.002 136.966 1.00 30.47  ? 19  ARG A CB   1 
ATOM   2095 C CG   . ARG B 1 19  ? 133.287 129.657 136.341 1.00 35.64  ? 19  ARG A CG   1 
ATOM   2096 C CD   . ARG B 1 19  ? 133.025 128.619 137.417 1.00 35.11  ? 19  ARG A CD   1 
ATOM   2097 N NE   . ARG B 1 19  ? 131.744 128.832 138.079 1.00 36.95  ? 19  ARG A NE   1 
ATOM   2098 C CZ   . ARG B 1 19  ? 131.590 128.945 139.391 1.00 38.75  ? 19  ARG A CZ   1 
ATOM   2099 N NH1  . ARG B 1 19  ? 132.619 128.861 140.219 1.00 34.73  ? 19  ARG A NH1  1 
ATOM   2100 N NH2  . ARG B 1 19  ? 130.369 129.145 139.885 1.00 40.19  ? 19  ARG A NH2  1 
ATOM   2101 N N    . PHE B 1 20  ? 132.653 133.010 134.708 1.00 27.79  ? 20  PHE A N    1 
ATOM   2102 C CA   . PHE B 1 20  ? 131.940 133.298 133.469 1.00 24.91  ? 20  PHE A CA   1 
ATOM   2103 C C    . PHE B 1 20  ? 132.872 133.915 132.429 1.00 30.25  ? 20  PHE A C    1 
ATOM   2104 O O    . PHE B 1 20  ? 132.901 133.488 131.265 1.00 35.76  ? 20  PHE A O    1 
ATOM   2105 C CB   . PHE B 1 20  ? 130.767 134.235 133.774 1.00 21.20  ? 20  PHE A CB   1 
ATOM   2106 C CG   . PHE B 1 20  ? 129.674 134.213 132.745 1.00 28.02  ? 20  PHE A CG   1 
ATOM   2107 C CD1  . PHE B 1 20  ? 129.169 133.011 132.277 1.00 30.29  ? 20  PHE A CD1  1 
ATOM   2108 C CD2  . PHE B 1 20  ? 129.140 135.393 132.259 1.00 25.33  ? 20  PHE A CD2  1 
ATOM   2109 C CE1  . PHE B 1 20  ? 128.158 132.990 131.338 1.00 32.16  ? 20  PHE A CE1  1 
ATOM   2110 C CE2  . PHE B 1 20  ? 128.131 135.376 131.317 1.00 22.01  ? 20  PHE A CE2  1 
ATOM   2111 C CZ   . PHE B 1 20  ? 127.639 134.173 130.856 1.00 26.37  ? 20  PHE A CZ   1 
ATOM   2112 N N    . LEU B 1 21  ? 133.663 134.908 132.845 1.00 26.75  ? 21  LEU A N    1 
ATOM   2113 C CA   . LEU B 1 21  ? 134.590 135.568 131.929 1.00 24.16  ? 21  LEU A CA   1 
ATOM   2114 C C    . LEU B 1 21  ? 135.657 134.608 131.419 1.00 30.70  ? 21  LEU A C    1 
ATOM   2115 O O    . LEU B 1 21  ? 135.988 134.604 130.226 1.00 37.08  ? 21  LEU A O    1 
ATOM   2116 C CB   . LEU B 1 21  ? 135.232 136.770 132.622 1.00 24.50  ? 21  LEU A CB   1 
ATOM   2117 C CG   . LEU B 1 21  ? 136.116 137.680 131.770 1.00 27.40  ? 21  LEU A CG   1 
ATOM   2118 C CD1  . LEU B 1 21  ? 135.283 138.473 130.776 1.00 31.40  ? 21  LEU A CD1  1 
ATOM   2119 C CD2  . LEU B 1 21  ? 136.923 138.612 132.658 1.00 23.54  ? 21  LEU A CD2  1 
ATOM   2120 N N    . LEU B 1 22  ? 136.209 133.781 132.314 1.00 27.21  ? 22  LEU A N    1 
ATOM   2121 C CA   . LEU B 1 22  ? 137.233 132.825 131.911 1.00 28.63  ? 22  LEU A CA   1 
ATOM   2122 C C    . LEU B 1 22  ? 136.684 131.822 130.909 1.00 34.28  ? 22  LEU A C    1 
ATOM   2123 O O    . LEU B 1 22  ? 137.342 131.510 129.907 1.00 41.51  ? 22  LEU A O    1 
ATOM   2124 C CB   . LEU B 1 22  ? 137.782 132.107 133.144 1.00 28.61  ? 22  LEU A CB   1 
ATOM   2125 C CG   . LEU B 1 22  ? 138.916 131.103 132.927 1.00 32.80  ? 22  LEU A CG   1 
ATOM   2126 C CD1  . LEU B 1 22  ? 140.194 131.815 132.508 1.00 30.81  ? 22  LEU A CD1  1 
ATOM   2127 C CD2  . LEU B 1 22  ? 139.139 130.288 134.184 1.00 28.32  ? 22  LEU A CD2  1 
ATOM   2128 N N    . LEU B 1 23  ? 135.476 131.307 131.156 1.00 21.41  ? 23  LEU A N    1 
ATOM   2129 C CA   . LEU B 1 23  ? 134.881 130.360 130.225 1.00 18.49  ? 23  LEU A CA   1 
ATOM   2130 C C    . LEU B 1 23  ? 134.634 131.006 128.869 1.00 28.52  ? 23  LEU A C    1 
ATOM   2131 O O    . LEU B 1 23  ? 134.880 130.387 127.824 1.00 33.30  ? 23  LEU A O    1 
ATOM   2132 C CB   . LEU B 1 23  ? 133.583 129.798 130.803 1.00 20.62  ? 23  LEU A CB   1 
ATOM   2133 C CG   . LEU B 1 23  ? 132.900 128.678 130.018 1.00 26.15  ? 23  LEU A CG   1 
ATOM   2134 C CD1  . LEU B 1 23  ? 133.873 127.551 129.724 1.00 25.82  ? 23  LEU A CD1  1 
ATOM   2135 C CD2  . LEU B 1 23  ? 131.687 128.154 130.770 1.00 22.54  ? 23  LEU A CD2  1 
ATOM   2136 N N    . ALA B 1 24  ? 134.159 132.256 128.859 1.00 29.28  ? 24  ALA A N    1 
ATOM   2137 C CA   . ALA B 1 24  ? 133.933 132.944 127.590 1.00 21.50  ? 24  ALA A CA   1 
ATOM   2138 C C    . ALA B 1 24  ? 135.234 133.103 126.809 1.00 32.75  ? 24  ALA A C    1 
ATOM   2139 O O    . ALA B 1 24  ? 135.284 132.843 125.597 1.00 37.84  ? 24  ALA A O    1 
ATOM   2140 C CB   . ALA B 1 24  ? 133.283 134.304 127.840 1.00 17.15  ? 24  ALA A CB   1 
ATOM   2141 N N    . ALA B 1 25  ? 136.304 133.527 127.489 1.00 26.83  ? 25  ALA A N    1 
ATOM   2142 C CA   . ALA B 1 25  ? 137.588 133.699 126.810 1.00 23.00  ? 25  ALA A CA   1 
ATOM   2143 C C    . ALA B 1 25  ? 138.117 132.373 126.267 1.00 28.27  ? 25  ALA A C    1 
ATOM   2144 O O    . ALA B 1 25  ? 138.626 132.309 125.136 1.00 32.13  ? 25  ALA A O    1 
ATOM   2145 C CB   . ALA B 1 25  ? 138.603 134.334 127.761 1.00 19.06  ? 25  ALA A CB   1 
ATOM   2146 N N    . LEU B 1 26  ? 138.003 131.303 127.060 1.00 28.92  ? 26  LEU A N    1 
ATOM   2147 C CA   . LEU B 1 26  ? 138.472 130.000 126.603 1.00 23.88  ? 26  LEU A CA   1 
ATOM   2148 C C    . LEU B 1 26  ? 137.691 129.528 125.387 1.00 24.39  ? 26  LEU A C    1 
ATOM   2149 O O    . LEU B 1 26  ? 138.269 128.975 124.445 1.00 29.95  ? 26  LEU A O    1 
ATOM   2150 C CB   . LEU B 1 26  ? 138.383 128.971 127.732 1.00 27.38  ? 26  LEU A CB   1 
ATOM   2151 C CG   . LEU B 1 26  ? 139.318 129.174 128.924 1.00 23.13  ? 26  LEU A CG   1 
ATOM   2152 C CD1  . LEU B 1 26  ? 139.124 128.072 129.950 1.00 25.19  ? 26  LEU A CD1  1 
ATOM   2153 C CD2  . LEU B 1 26  ? 140.764 129.229 128.467 1.00 19.84  ? 26  LEU A CD2  1 
ATOM   2154 N N    . ILE B 1 27  ? 136.373 129.740 125.386 1.00 17.88  ? 27  ILE A N    1 
ATOM   2155 C CA   . ILE B 1 27  ? 135.563 129.332 124.242 1.00 20.60  ? 27  ILE A CA   1 
ATOM   2156 C C    . ILE B 1 27  ? 135.944 130.132 123.002 1.00 21.87  ? 27  ILE A C    1 
ATOM   2157 O O    . ILE B 1 27  ? 135.985 129.595 121.889 1.00 23.18  ? 27  ILE A O    1 
ATOM   2158 C CB   . ILE B 1 27  ? 134.063 129.456 124.568 1.00 24.97  ? 27  ILE A CB   1 
ATOM   2159 C CG1  . ILE B 1 27  ? 133.677 128.460 125.663 1.00 17.51  ? 27  ILE A CG1  1 
ATOM   2160 C CG2  . ILE B 1 27  ? 133.214 129.223 123.327 1.00 24.55  ? 27  ILE A CG2  1 
ATOM   2161 C CD1  . ILE B 1 27  ? 132.230 128.545 126.089 1.00 13.91  ? 27  ILE A CD1  1 
ATOM   2162 N N    . VAL B 1 28  ? 136.234 131.426 123.166 1.00 25.68  ? 28  VAL A N    1 
ATOM   2163 C CA   . VAL B 1 28  ? 136.633 132.243 122.020 1.00 26.08  ? 28  VAL A CA   1 
ATOM   2164 C C    . VAL B 1 28  ? 137.941 131.724 121.422 1.00 25.70  ? 28  VAL A C    1 
ATOM   2165 O O    . VAL B 1 28  ? 138.071 131.572 120.196 1.00 31.35  ? 28  VAL A O    1 
ATOM   2166 C CB   . VAL B 1 28  ? 136.748 133.722 122.432 1.00 23.31  ? 28  VAL A CB   1 
ATOM   2167 C CG1  . VAL B 1 28  ? 137.440 134.529 121.346 1.00 22.69  ? 28  VAL A CG1  1 
ATOM   2168 C CG2  . VAL B 1 28  ? 135.371 134.301 122.718 1.00 22.44  ? 28  VAL A CG2  1 
ATOM   2169 N N    . LEU B 1 29  ? 138.928 131.446 122.276 1.00 20.49  ? 29  LEU A N    1 
ATOM   2170 C CA   . LEU B 1 29  ? 140.196 130.912 121.778 1.00 22.78  ? 29  LEU A CA   1 
ATOM   2171 C C    . LEU B 1 29  ? 140.005 129.554 121.111 1.00 29.21  ? 29  LEU A C    1 
ATOM   2172 O O    . LEU B 1 29  ? 140.617 129.266 120.071 1.00 32.33  ? 29  LEU A O    1 
ATOM   2173 C CB   . LEU B 1 29  ? 141.211 130.811 122.916 1.00 22.68  ? 29  LEU A CB   1 
ATOM   2174 C CG   . LEU B 1 29  ? 141.700 132.130 123.515 1.00 23.45  ? 29  LEU A CG   1 
ATOM   2175 C CD1  . LEU B 1 29  ? 142.759 131.877 124.571 1.00 19.38  ? 29  LEU A CD1  1 
ATOM   2176 C CD2  . LEU B 1 29  ? 142.243 133.044 122.429 1.00 24.02  ? 29  LEU A CD2  1 
ATOM   2177 N N    . TYR B 1 30  ? 139.156 128.704 121.699 1.00 23.09  ? 30  TYR A N    1 
ATOM   2178 C CA   . TYR B 1 30  ? 138.843 127.405 121.116 1.00 16.95  ? 30  TYR A CA   1 
ATOM   2179 C C    . TYR B 1 30  ? 138.264 127.562 119.719 1.00 20.61  ? 30  TYR A C    1 
ATOM   2180 O O    . TYR B 1 30  ? 138.654 126.853 118.783 1.00 26.85  ? 30  TYR A O    1 
ATOM   2181 C CB   . TYR B 1 30  ? 137.871 126.655 122.031 1.00 15.76  ? 30  TYR A CB   1 
ATOM   2182 C CG   . TYR B 1 30  ? 137.735 125.176 121.755 1.00 24.67  ? 30  TYR A CG   1 
ATOM   2183 C CD1  . TYR B 1 30  ? 138.788 124.304 121.996 1.00 17.47  ? 30  TYR A CD1  1 
ATOM   2184 C CD2  . TYR B 1 30  ? 136.543 124.646 121.281 1.00 19.98  ? 30  TYR A CD2  1 
ATOM   2185 C CE1  . TYR B 1 30  ? 138.664 122.951 121.755 1.00 14.58  ? 30  TYR A CE1  1 
ATOM   2186 C CE2  . TYR B 1 30  ? 136.410 123.293 121.037 1.00 20.06  ? 30  TYR A CE2  1 
ATOM   2187 C CZ   . TYR B 1 30  ? 137.473 122.450 121.276 1.00 16.71  ? 30  TYR A CZ   1 
ATOM   2188 O OH   . TYR B 1 30  ? 137.339 121.103 121.035 1.00 21.97  ? 30  TYR A OH   1 
ATOM   2189 N N    . LEU B 1 31  ? 137.325 128.500 119.560 1.00 16.04  ? 31  LEU A N    1 
ATOM   2190 C CA   . LEU B 1 31  ? 136.702 128.722 118.261 1.00 15.90  ? 31  LEU A CA   1 
ATOM   2191 C C    . LEU B 1 31  ? 137.723 129.186 117.232 1.00 19.08  ? 31  LEU A C    1 
ATOM   2192 O O    . LEU B 1 31  ? 137.723 128.712 116.089 1.00 25.25  ? 31  LEU A O    1 
ATOM   2193 C CB   . LEU B 1 31  ? 135.572 129.744 118.387 1.00 13.65  ? 31  LEU A CB   1 
ATOM   2194 C CG   . LEU B 1 31  ? 134.298 129.295 119.102 1.00 14.13  ? 31  LEU A CG   1 
ATOM   2195 C CD1  . LEU B 1 31  ? 133.272 130.418 119.115 1.00 13.06  ? 31  LEU A CD1  1 
ATOM   2196 C CD2  . LEU B 1 31  ? 133.718 128.051 118.454 1.00 16.25  ? 31  LEU A CD2  1 
ATOM   2197 N N    . LEU B 1 32  ? 138.609 130.111 117.619 1.00 15.99  ? 32  LEU A N    1 
ATOM   2198 C CA   . LEU B 1 32  ? 139.612 130.600 116.674 1.00 17.34  ? 32  LEU A CA   1 
ATOM   2199 C C    . LEU B 1 32  ? 140.541 129.477 116.222 1.00 22.69  ? 32  LEU A C    1 
ATOM   2200 O O    . LEU B 1 32  ? 140.802 129.306 115.018 1.00 24.74  ? 32  LEU A O    1 
ATOM   2201 C CB   . LEU B 1 32  ? 140.412 131.743 117.300 1.00 18.89  ? 32  LEU A CB   1 
ATOM   2202 C CG   . LEU B 1 32  ? 139.674 133.053 117.579 1.00 16.04  ? 32  LEU A CG   1 
ATOM   2203 C CD1  . LEU B 1 32  ? 140.592 134.051 118.262 1.00 18.72  ? 32  LEU A CD1  1 
ATOM   2204 C CD2  . LEU B 1 32  ? 139.114 133.646 116.294 1.00 20.19  ? 32  LEU A CD2  1 
ATOM   2205 N N    . GLY B 1 33  ? 141.047 128.690 117.177 1.00 23.06  ? 33  GLY A N    1 
ATOM   2206 C CA   . GLY B 1 33  ? 141.935 127.595 116.818 1.00 16.97  ? 33  GLY A CA   1 
ATOM   2207 C C    . GLY B 1 33  ? 141.259 126.552 115.945 1.00 22.97  ? 33  GLY A C    1 
ATOM   2208 O O    . GLY B 1 33  ? 141.840 126.070 114.965 1.00 28.07  ? 33  GLY A O    1 
ATOM   2209 N N    . GLY B 1 34  ? 140.017 126.194 116.285 1.00 20.18  ? 34  GLY A N    1 
ATOM   2210 C CA   . GLY B 1 34  ? 139.293 125.231 115.477 1.00 14.81  ? 34  GLY A CA   1 
ATOM   2211 C C    . GLY B 1 34  ? 139.040 125.730 114.069 1.00 23.05  ? 34  GLY A C    1 
ATOM   2212 O O    . GLY B 1 34  ? 139.131 124.963 113.106 1.00 30.21  ? 34  GLY A O    1 
ATOM   2213 N N    . ALA B 1 35  ? 138.718 127.017 113.928 1.00 18.25  ? 35  ALA A N    1 
ATOM   2214 C CA   . ALA B 1 35  ? 138.525 127.588 112.601 1.00 15.49  ? 35  ALA A CA   1 
ATOM   2215 C C    . ALA B 1 35  ? 139.798 127.479 111.772 1.00 16.68  ? 35  ALA A C    1 
ATOM   2216 O O    . ALA B 1 35  ? 139.762 127.074 110.603 1.00 24.65  ? 35  ALA A O    1 
ATOM   2217 C CB   . ALA B 1 35  ? 138.078 129.047 112.715 1.00 15.13  ? 35  ALA A CB   1 
ATOM   2218 N N    . ALA B 1 36  ? 140.942 127.824 112.372 1.00 21.13  ? 36  ALA A N    1 
ATOM   2219 C CA   . ALA B 1 36  ? 142.205 127.734 111.644 1.00 18.72  ? 36  ALA A CA   1 
ATOM   2220 C C    . ALA B 1 36  ? 142.474 126.300 111.191 1.00 26.35  ? 36  ALA A C    1 
ATOM   2221 O O    . ALA B 1 36  ? 142.816 126.052 110.025 1.00 31.18  ? 36  ALA A O    1 
ATOM   2222 C CB   . ALA B 1 36  ? 143.353 128.254 112.507 1.00 16.79  ? 36  ALA A CB   1 
ATOM   2223 N N    . VAL B 1 37  ? 142.292 125.336 112.100 1.00 25.79  ? 37  VAL A N    1 
ATOM   2224 C CA   . VAL B 1 37  ? 142.602 123.947 111.771 1.00 22.04  ? 37  VAL A CA   1 
ATOM   2225 C C    . VAL B 1 37  ? 141.674 123.432 110.675 1.00 24.04  ? 37  VAL A C    1 
ATOM   2226 O O    . VAL B 1 37  ? 142.121 122.781 109.720 1.00 28.80  ? 37  VAL A O    1 
ATOM   2227 C CB   . VAL B 1 37  ? 142.538 123.067 113.034 1.00 21.80  ? 37  VAL A CB   1 
ATOM   2228 C CG1  . VAL B 1 37  ? 142.715 121.605 112.668 1.00 24.44  ? 37  VAL A CG1  1 
ATOM   2229 C CG2  . VAL B 1 37  ? 143.601 123.495 114.030 1.00 21.90  ? 37  VAL A CG2  1 
ATOM   2230 N N    . PHE B 1 38  ? 140.373 123.715 110.790 1.00 21.84  ? 38  PHE A N    1 
ATOM   2231 C CA   . PHE B 1 38  ? 139.419 123.217 109.801 1.00 17.75  ? 38  PHE A CA   1 
ATOM   2232 C C    . PHE B 1 38  ? 139.679 123.824 108.429 1.00 23.04  ? 38  PHE A C    1 
ATOM   2233 O O    . PHE B 1 38  ? 139.593 123.127 107.407 1.00 24.14  ? 38  PHE A O    1 
ATOM   2234 C CB   . PHE B 1 38  ? 137.989 123.511 110.255 1.00 10.59  ? 38  PHE A CB   1 
ATOM   2235 C CG   . PHE B 1 38  ? 137.370 122.411 111.074 1.00 21.85  ? 38  PHE A CG   1 
ATOM   2236 C CD1  . PHE B 1 38  ? 137.064 121.189 110.500 1.00 17.13  ? 38  PHE A CD1  1 
ATOM   2237 C CD2  . PHE B 1 38  ? 137.080 122.604 112.416 1.00 24.63  ? 38  PHE A CD2  1 
ATOM   2238 C CE1  . PHE B 1 38  ? 136.492 120.178 111.249 1.00 20.28  ? 38  PHE A CE1  1 
ATOM   2239 C CE2  . PHE B 1 38  ? 136.507 121.600 113.170 1.00 17.31  ? 38  PHE A CE2  1 
ATOM   2240 C CZ   . PHE B 1 38  ? 136.213 120.382 112.584 1.00 20.78  ? 38  PHE A CZ   1 
ATOM   2241 N N    . SER B 1 39  ? 139.985 125.125 108.377 1.00 27.25  ? 39  SER A N    1 
ATOM   2242 C CA   . SER B 1 39  ? 140.308 125.750 107.098 1.00 24.09  ? 39  SER A CA   1 
ATOM   2243 C C    . SER B 1 39  ? 141.528 125.091 106.468 1.00 27.58  ? 39  SER A C    1 
ATOM   2244 O O    . SER B 1 39  ? 141.520 124.736 105.279 1.00 32.19  ? 39  SER A O    1 
ATOM   2245 C CB   . SER B 1 39  ? 140.535 127.250 107.292 1.00 22.31  ? 39  SER A CB   1 
ATOM   2246 O OG   . SER B 1 39  ? 141.267 127.802 106.212 1.00 31.03  ? 39  SER A OG   1 
ATOM   2247 N N    . ALA B 1 40  ? 142.583 124.886 107.269 1.00 31.53  ? 40  ALA A N    1 
ATOM   2248 C CA   . ALA B 1 40  ? 143.788 124.240 106.753 1.00 25.87  ? 40  ALA A CA   1 
ATOM   2249 C C    . ALA B 1 40  ? 143.496 122.832 106.252 1.00 24.16  ? 40  ALA A C    1 
ATOM   2250 O O    . ALA B 1 40  ? 144.133 122.366 105.301 1.00 31.68  ? 40  ALA A O    1 
ATOM   2251 C CB   . ALA B 1 40  ? 144.870 124.203 107.832 1.00 26.14  ? 40  ALA A CB   1 
ATOM   2252 N N    . LEU B 1 41  ? 142.545 122.139 106.878 1.00 28.54  ? 41  LEU A N    1 
ATOM   2253 C CA   . LEU B 1 41  ? 142.220 120.782 106.452 1.00 20.92  ? 41  LEU A CA   1 
ATOM   2254 C C    . LEU B 1 41  ? 141.378 120.739 105.179 1.00 28.85  ? 41  LEU A C    1 
ATOM   2255 O O    . LEU B 1 41  ? 141.522 119.799 104.389 1.00 29.80  ? 41  LEU A O    1 
ATOM   2256 C CB   . LEU B 1 41  ? 141.491 120.038 107.572 1.00 18.23  ? 41  LEU A CB   1 
ATOM   2257 C CG   . LEU B 1 41  ? 142.344 119.519 108.733 1.00 21.82  ? 41  LEU A CG   1 
ATOM   2258 C CD1  . LEU B 1 41  ? 141.460 118.936 109.820 1.00 20.50  ? 41  LEU A CD1  1 
ATOM   2259 C CD2  . LEU B 1 41  ? 143.354 118.492 108.249 1.00 20.82  ? 41  LEU A CD2  1 
ATOM   2260 N N    . GLU B 1 42  ? 140.500 121.720 104.958 1.00 34.56  ? 42  GLU A N    1 
ATOM   2261 C CA   . GLU B 1 42  ? 139.459 121.571 103.945 1.00 24.31  ? 42  GLU A CA   1 
ATOM   2262 C C    . GLU B 1 42  ? 139.592 122.468 102.716 1.00 27.81  ? 42  GLU A C    1 
ATOM   2263 O O    . GLU B 1 42  ? 138.889 122.221 101.721 1.00 36.11  ? 42  GLU A O    1 
ATOM   2264 C CB   . GLU B 1 42  ? 138.079 121.798 104.580 1.00 29.43  ? 42  GLU A CB   1 
ATOM   2265 C CG   . GLU B 1 42  ? 137.771 120.861 105.735 1.00 22.50  ? 42  GLU A CG   1 
ATOM   2266 C CD   . GLU B 1 42  ? 137.212 119.526 105.271 1.00 33.36  ? 42  GLU A CD   1 
ATOM   2267 O OE1  . GLU B 1 42  ? 136.626 119.476 104.169 1.00 44.51  ? 42  GLU A OE1  1 
ATOM   2268 O OE2  . GLU B 1 42  ? 137.357 118.532 106.007 1.00 39.30  ? 42  GLU A OE2  1 
ATOM   2269 N N    . LEU B 1 43  ? 140.438 123.507 102.752 1.00 30.18  ? 43  LEU A N    1 
ATOM   2270 C CA   . LEU B 1 43  ? 140.427 124.491 101.665 1.00 30.93  ? 43  LEU A CA   1 
ATOM   2271 C C    . LEU B 1 43  ? 140.795 123.868 100.318 1.00 36.37  ? 43  LEU A C    1 
ATOM   2272 O O    . LEU B 1 43  ? 140.148 124.152 99.297  1.00 41.23  ? 43  LEU A O    1 
ATOM   2273 C CB   . LEU B 1 43  ? 141.379 125.640 101.995 1.00 35.12  ? 43  LEU A CB   1 
ATOM   2274 C CG   . LEU B 1 43  ? 141.193 126.940 101.207 1.00 33.81  ? 43  LEU A CG   1 
ATOM   2275 C CD1  . LEU B 1 43  ? 139.724 127.235 100.966 1.00 33.93  ? 43  LEU A CD1  1 
ATOM   2276 C CD2  . LEU B 1 43  ? 141.860 128.101 101.922 1.00 36.19  ? 43  LEU A CD2  1 
ATOM   2277 N N    . ALA B 1 44  ? 141.835 123.031 100.287 1.00 37.74  ? 44  ALA A N    1 
ATOM   2278 C CA   . ALA B 1 44  ? 142.293 122.468 99.019  1.00 35.21  ? 44  ALA A CA   1 
ATOM   2279 C C    . ALA B 1 44  ? 141.232 121.564 98.407  1.00 44.03  ? 44  ALA A C    1 
ATOM   2280 O O    . ALA B 1 44  ? 140.975 121.619 97.196  1.00 50.94  ? 44  ALA A O    1 
ATOM   2281 C CB   . ALA B 1 44  ? 143.603 121.707 99.219  1.00 37.95  ? 44  ALA A CB   1 
ATOM   2282 N N    . HIS B 1 45  ? 140.615 120.716 99.234  1.00 40.46  ? 45  HIS A N    1 
ATOM   2283 C CA   . HIS B 1 45  ? 139.558 119.835 98.754  1.00 37.20  ? 45  HIS A CA   1 
ATOM   2284 C C    . HIS B 1 45  ? 138.425 120.659 98.158  1.00 43.50  ? 45  HIS A C    1 
ATOM   2285 O O    . HIS B 1 45  ? 137.910 120.342 97.078  1.00 47.21  ? 45  HIS A O    1 
ATOM   2286 C CB   . HIS B 1 45  ? 139.051 118.941 99.887  1.00 39.19  ? 45  HIS A CB   1 
ATOM   2287 C CG   . HIS B 1 45  ? 137.937 118.029 99.479  1.00 46.84  ? 45  HIS A CG   1 
ATOM   2288 N ND1  . HIS B 1 45  ? 138.079 117.071 98.498  1.00 49.92  ? 45  HIS A ND1  1 
ATOM   2289 C CD2  . HIS B 1 45  ? 136.661 117.926 99.921  1.00 46.84  ? 45  HIS A CD2  1 
ATOM   2290 C CE1  . HIS B 1 45  ? 136.941 116.421 98.352  1.00 45.75  ? 45  HIS A CE1  1 
ATOM   2291 N NE2  . HIS B 1 45  ? 136.064 116.921 99.203  1.00 43.48  ? 45  HIS A NE2  1 
ATOM   2292 N N    . GLU B 1 46  ? 137.986 121.690 98.890  1.00 43.66  ? 46  GLU A N    1 
ATOM   2293 C CA   . GLU B 1 46  ? 136.905 122.542 98.398  1.00 37.87  ? 46  GLU A CA   1 
ATOM   2294 C C    . GLU B 1 46  ? 137.246 123.095 97.018  1.00 36.21  ? 46  GLU A C    1 
ATOM   2295 O O    . GLU B 1 46  ? 136.440 123.011 96.080  1.00 42.39  ? 46  GLU A O    1 
ATOM   2296 C CB   . GLU B 1 46  ? 136.635 123.675 99.386  1.00 40.29  ? 46  GLU A CB   1 
ATOM   2297 C CG   . GLU B 1 46  ? 135.449 124.549 99.010  1.00 43.59  ? 46  GLU A CG   1 
ATOM   2298 C CD   . GLU B 1 46  ? 135.602 125.978 99.485  1.00 47.72  ? 46  GLU A CD   1 
ATOM   2299 O OE1  . GLU B 1 46  ? 136.673 126.310 100.036 1.00 47.25  ? 46  GLU A OE1  1 
ATOM   2300 O OE2  . GLU B 1 46  ? 134.657 126.774 99.306  1.00 49.91  ? 46  GLU A OE2  1 
ATOM   2301 N N    . ARG B 1 47  ? 138.417 123.732 96.896  1.00 39.02  ? 47  ARG A N    1 
ATOM   2302 C CA   . ARG B 1 47  ? 138.800 124.345 95.626  1.00 41.15  ? 47  ARG A CA   1 
ATOM   2303 C C    . ARG B 1 47  ? 138.828 123.320 94.497  1.00 44.84  ? 47  ARG A C    1 
ATOM   2304 O O    . ARG B 1 47  ? 138.376 123.601 93.376  1.00 50.11  ? 47  ARG A O    1 
ATOM   2305 C CB   . ARG B 1 47  ? 140.159 125.036 95.751  1.00 44.16  ? 47  ARG A CB   1 
ATOM   2306 C CG   . ARG B 1 47  ? 140.077 126.510 96.112  1.00 47.09  ? 47  ARG A CG   1 
ATOM   2307 C CD   . ARG B 1 47  ? 141.366 127.007 96.744  1.00 48.60  ? 47  ARG A CD   1 
ATOM   2308 N NE   . ARG B 1 47  ? 141.275 128.414 97.117  1.00 52.63  ? 47  ARG A NE   1 
ATOM   2309 C CZ   . ARG B 1 47  ? 142.188 129.064 97.824  1.00 54.11  ? 47  ARG A CZ   1 
ATOM   2310 N NH1  . ARG B 1 47  ? 143.284 128.463 98.256  1.00 51.42  ? 47  ARG A NH1  1 
ATOM   2311 N NH2  . ARG B 1 47  ? 142.000 130.351 98.101  1.00 53.39  ? 47  ARG A NH2  1 
ATOM   2312 N N    . GLN B 1 48  ? 139.368 122.125 94.767  1.00 47.76  ? 48  GLN A N    1 
ATOM   2313 C CA   . GLN B 1 48  ? 139.429 121.094 93.734  1.00 48.19  ? 48  GLN A CA   1 
ATOM   2314 C C    . GLN B 1 48  ? 138.034 120.665 93.296  1.00 48.10  ? 48  GLN A C    1 
ATOM   2315 O O    . GLN B 1 48  ? 137.778 120.479 92.098  1.00 49.85  ? 48  GLN A O    1 
ATOM   2316 C CB   . GLN B 1 48  ? 140.223 119.893 94.246  1.00 48.45  ? 48  GLN A CB   1 
ATOM   2317 C CG   . GLN B 1 48  ? 141.135 119.263 93.210  1.00 51.87  ? 48  GLN A CG   1 
ATOM   2318 C CD   . GLN B 1 48  ? 142.427 118.745 93.813  1.00 57.21  ? 48  GLN A CD   1 
ATOM   2319 O OE1  . GLN B 1 48  ? 142.519 118.535 95.025  1.00 56.97  ? 48  GLN A OE1  1 
ATOM   2320 N NE2  . GLN B 1 48  ? 143.431 118.534 92.973  1.00 56.44  ? 48  GLN A NE2  1 
ATOM   2321 N N    . ALA B 1 49  ? 137.112 120.508 94.251  1.00 46.75  ? 49  ALA A N    1 
ATOM   2322 C CA   . ALA B 1 49  ? 135.744 120.134 93.902  1.00 43.58  ? 49  ALA A CA   1 
ATOM   2323 C C    . ALA B 1 49  ? 135.081 121.210 93.049  1.00 46.98  ? 49  ALA A C    1 
ATOM   2324 O O    . ALA B 1 49  ? 134.372 120.897 92.081  1.00 47.80  ? 49  ALA A O    1 
ATOM   2325 C CB   . ALA B 1 49  ? 134.933 119.875 95.170  1.00 41.97  ? 49  ALA A CB   1 
ATOM   2326 N N    . LYS B 1 50  ? 135.296 122.480 93.398  1.00 47.12  ? 50  LYS A N    1 
ATOM   2327 C CA   . LYS B 1 50  ? 134.708 123.562 92.615  1.00 43.25  ? 50  LYS A CA   1 
ATOM   2328 C C    . LYS B 1 50  ? 135.257 123.578 91.194  1.00 44.40  ? 50  LYS A C    1 
ATOM   2329 O O    . LYS B 1 50  ? 134.503 123.771 90.227  1.00 51.51  ? 50  LYS A O    1 
ATOM   2330 C CB   . LYS B 1 50  ? 134.945 124.902 93.309  1.00 42.91  ? 50  LYS A CB   1 
ATOM   2331 C CG   . LYS B 1 50  ? 134.110 125.086 94.565  1.00 44.61  ? 50  LYS A CG   1 
ATOM   2332 C CD   . LYS B 1 50  ? 134.240 126.485 95.135  1.00 44.77  ? 50  LYS A CD   1 
ATOM   2333 C CE   . LYS B 1 50  ? 132.937 126.929 95.783  1.00 47.08  ? 50  LYS A CE   1 
ATOM   2334 N NZ   . LYS B 1 50  ? 133.038 126.964 97.266  1.00 47.46  ? 50  LYS A NZ   1 
ATOM   2335 N N    . GLN B 1 51  ? 136.569 123.372 91.042  1.00 46.74  ? 51  GLN A N    1 
ATOM   2336 C CA   . GLN B 1 51  ? 137.152 123.328 89.702  1.00 45.60  ? 51  GLN A CA   1 
ATOM   2337 C C    . GLN B 1 51  ? 136.583 122.163 88.898  1.00 48.38  ? 51  GLN A C    1 
ATOM   2338 O O    . GLN B 1 51  ? 136.303 122.300 87.698  1.00 53.49  ? 51  GLN A O    1 
ATOM   2339 C CB   . GLN B 1 51  ? 138.675 123.235 89.794  1.00 47.31  ? 51  GLN A CB   1 
ATOM   2340 C CG   . GLN B 1 51  ? 139.356 122.951 88.468  1.00 50.83  ? 51  GLN A CG   1 
ATOM   2341 C CD   . GLN B 1 51  ? 140.839 122.683 88.623  1.00 57.63  ? 51  GLN A CD   1 
ATOM   2342 O OE1  . GLN B 1 51  ? 141.354 122.608 89.740  1.00 60.21  ? 51  GLN A OE1  1 
ATOM   2343 N NE2  . GLN B 1 51  ? 141.535 122.538 87.501  1.00 52.21  ? 51  GLN A NE2  1 
ATOM   2344 N N    . ARG B 1 52  ? 136.409 121.006 89.544  1.00 48.92  ? 52  ARG A N    1 
ATOM   2345 C CA   . ARG B 1 52  ? 135.844 119.852 88.847  1.00 47.21  ? 52  ARG A CA   1 
ATOM   2346 C C    . ARG B 1 52  ? 134.420 120.141 88.383  1.00 48.65  ? 52  ARG A C    1 
ATOM   2347 O O    . ARG B 1 52  ? 134.047 119.803 87.249  1.00 51.77  ? 52  ARG A O    1 
ATOM   2348 C CB   . ARG B 1 52  ? 135.873 118.632 89.768  1.00 44.30  ? 52  ARG A CB   1 
ATOM   2349 C CG   . ARG B 1 52  ? 135.175 117.406 89.220  1.00 45.55  ? 52  ARG A CG   1 
ATOM   2350 C CD   . ARG B 1 52  ? 135.806 116.147 89.778  1.00 46.70  ? 52  ARG A CD   1 
ATOM   2351 N NE   . ARG B 1 52  ? 135.651 116.081 91.227  1.00 50.98  ? 52  ARG A NE   1 
ATOM   2352 C CZ   . ARG B 1 52  ? 136.658 116.045 92.088  1.00 51.99  ? 52  ARG A CZ   1 
ATOM   2353 N NH1  . ARG B 1 52  ? 137.916 116.058 91.681  1.00 48.24  ? 52  ARG A NH1  1 
ATOM   2354 N NH2  . ARG B 1 52  ? 136.394 115.996 93.391  1.00 49.04  ? 52  ARG A NH2  1 
ATOM   2355 N N    . TRP B 1 53  ? 133.615 120.776 89.240  1.00 47.23  ? 53  TRP A N    1 
ATOM   2356 C CA   . TRP B 1 53  ? 132.257 121.138 88.840  1.00 42.94  ? 53  TRP A CA   1 
ATOM   2357 C C    . TRP B 1 53  ? 132.270 122.099 87.663  1.00 40.74  ? 53  TRP A C    1 
ATOM   2358 O O    . TRP B 1 53  ? 131.442 121.986 86.750  1.00 44.18  ? 53  TRP A O    1 
ATOM   2359 C CB   . TRP B 1 53  ? 131.482 121.752 90.001  1.00 41.92  ? 53  TRP A CB   1 
ATOM   2360 C CG   . TRP B 1 53  ? 130.342 122.613 89.519  1.00 40.36  ? 53  TRP A CG   1 
ATOM   2361 C CD1  . TRP B 1 53  ? 130.225 123.964 89.652  1.00 43.70  ? 53  TRP A CD1  1 
ATOM   2362 C CD2  . TRP B 1 53  ? 129.194 122.184 88.771  1.00 43.17  ? 53  TRP A CD2  1 
ATOM   2363 N NE1  . TRP B 1 53  ? 129.063 124.401 89.065  1.00 41.86  ? 53  TRP A NE1  1 
ATOM   2364 C CE2  . TRP B 1 53  ? 128.412 123.328 88.512  1.00 42.49  ? 53  TRP A CE2  1 
ATOM   2365 C CE3  . TRP B 1 53  ? 128.744 120.943 88.306  1.00 42.86  ? 53  TRP A CE3  1 
ATOM   2366 C CZ2  . TRP B 1 53  ? 127.209 123.270 87.815  1.00 40.67  ? 53  TRP A CZ2  1 
ATOM   2367 C CZ3  . TRP B 1 53  ? 127.548 120.887 87.612  1.00 41.71  ? 53  TRP A CZ3  1 
ATOM   2368 C CH2  . TRP B 1 53  ? 126.795 122.044 87.374  1.00 37.46  ? 53  TRP A CH2  1 
ATOM   2369 N N    . GLU B 1 54  ? 133.194 123.062 87.664  1.00 52.55  ? 54  GLU A N    1 
ATOM   2370 C CA   . GLU B 1 54  ? 133.188 124.050 86.591  1.00 50.00  ? 54  GLU A CA   1 
ATOM   2371 C C    . GLU B 1 54  ? 133.593 123.402 85.276  1.00 52.57  ? 54  GLU A C    1 
ATOM   2372 O O    . GLU B 1 54  ? 133.026 123.713 84.218  1.00 56.40  ? 54  GLU A O    1 
ATOM   2373 C CB   . GLU B 1 54  ? 134.118 125.213 86.941  1.00 50.99  ? 54  GLU A CB   1 
ATOM   2374 C CG   . GLU B 1 54  ? 133.602 126.582 86.524  1.00 55.90  ? 54  GLU A CG   1 
ATOM   2375 C CD   . GLU B 1 54  ? 133.889 126.901 85.068  1.00 62.55  ? 54  GLU A CD   1 
ATOM   2376 O OE1  . GLU B 1 54  ? 134.618 126.125 84.419  1.00 60.55  ? 54  GLU A OE1  1 
ATOM   2377 O OE2  . GLU B 1 54  ? 133.380 127.927 84.574  1.00 62.04  ? 54  GLU A OE2  1 
ATOM   2378 N N    . GLU B 1 55  ? 134.536 122.459 85.328  1.00 55.75  ? 55  GLU A N    1 
ATOM   2379 C CA   . GLU B 1 55  ? 134.913 121.738 84.118  1.00 53.92  ? 55  GLU A CA   1 
ATOM   2380 C C    . GLU B 1 55  ? 133.750 120.901 83.596  1.00 55.71  ? 55  GLU A C    1 
ATOM   2381 O O    . GLU B 1 55  ? 133.489 120.869 82.387  1.00 55.08  ? 55  GLU A O    1 
ATOM   2382 C CB   . GLU B 1 55  ? 136.136 120.859 84.388  1.00 52.34  ? 55  GLU A CB   1 
ATOM   2383 C CG   . GLU B 1 55  ? 136.516 119.949 83.233  1.00 58.03  ? 55  GLU A CG   1 
ATOM   2384 C CD   . GLU B 1 55  ? 137.079 120.711 82.051  1.00 62.19  ? 55  GLU A CD   1 
ATOM   2385 O OE1  . GLU B 1 55  ? 137.503 121.873 82.231  1.00 62.80  ? 55  GLU A OE1  1 
ATOM   2386 O OE2  . GLU B 1 55  ? 137.101 120.147 80.936  1.00 61.97  ? 55  GLU A OE2  1 
ATOM   2387 N N    . ARG B 1 56  ? 133.034 120.218 84.496  1.00 57.52  ? 56  ARG A N    1 
ATOM   2388 C CA   . ARG B 1 56  ? 131.891 119.410 84.071  1.00 49.35  ? 56  ARG A CA   1 
ATOM   2389 C C    . ARG B 1 56  ? 130.800 120.271 83.446  1.00 52.71  ? 56  ARG A C    1 
ATOM   2390 O O    . ARG B 1 56  ? 130.219 119.903 82.415  1.00 55.24  ? 56  ARG A O    1 
ATOM   2391 C CB   . ARG B 1 56  ? 131.338 118.620 85.257  1.00 46.44  ? 56  ARG A CB   1 
ATOM   2392 C CG   . ARG B 1 56  ? 132.138 117.378 85.605  1.00 49.61  ? 56  ARG A CG   1 
ATOM   2393 C CD   . ARG B 1 56  ? 131.662 116.769 86.907  1.00 50.63  ? 56  ARG A CD   1 
ATOM   2394 N NE   . ARG B 1 56  ? 132.389 115.551 87.237  1.00 51.72  ? 56  ARG A NE   1 
ATOM   2395 C CZ   . ARG B 1 56  ? 132.346 114.948 88.418  1.00 52.86  ? 56  ARG A CZ   1 
ATOM   2396 N NH1  . ARG B 1 56  ? 131.619 115.431 89.413  1.00 51.41  ? 56  ARG A NH1  1 
ATOM   2397 N NH2  . ARG B 1 56  ? 133.041 113.829 88.603  1.00 53.90  ? 56  ARG A NH2  1 
ATOM   2398 N N    . LEU B 1 57  ? 130.502 121.419 84.059  1.00 51.45  ? 57  LEU A N    1 
ATOM   2399 C CA   . LEU B 1 57  ? 129.484 122.310 83.512  1.00 48.76  ? 57  LEU A CA   1 
ATOM   2400 C C    . LEU B 1 57  ? 129.886 122.835 82.142  1.00 53.44  ? 57  LEU A C    1 
ATOM   2401 O O    . LEU B 1 57  ? 129.059 122.884 81.219  1.00 54.60  ? 57  LEU A O    1 
ATOM   2402 C CB   . LEU B 1 57  ? 129.225 123.471 84.474  1.00 46.39  ? 57  LEU A CB   1 
ATOM   2403 C CG   . LEU B 1 57  ? 128.169 124.479 84.014  1.00 48.60  ? 57  LEU A CG   1 
ATOM   2404 C CD1  . LEU B 1 57  ? 126.772 124.010 84.367  1.00 53.15  ? 57  LEU A CD1  1 
ATOM   2405 C CD2  . LEU B 1 57  ? 128.436 125.841 84.628  1.00 51.76  ? 57  LEU A CD2  1 
ATOM   2406 N N    . ALA B 1 58  ? 131.154 123.222 81.981  1.00 60.89  ? 58  ALA A N    1 
ATOM   2407 C CA   . ALA B 1 58  ? 131.609 123.704 80.681  1.00 60.99  ? 58  ALA A CA   1 
ATOM   2408 C C    . ALA B 1 58  ? 131.517 122.611 79.627  1.00 63.23  ? 58  ALA A C    1 
ATOM   2409 O O    . ALA B 1 58  ? 131.102 122.870 78.487  1.00 61.34  ? 58  ALA A O    1 
ATOM   2410 C CB   . ALA B 1 58  ? 133.039 124.232 80.786  1.00 62.41  ? 58  ALA A CB   1 
ATOM   2411 N N    . GLN B 1 59  ? 131.894 121.380 79.983  1.00 68.46  ? 59  GLN A N    1 
ATOM   2412 C CA   . GLN B 1 59  ? 131.817 120.286 79.018  1.00 65.56  ? 59  GLN A CA   1 
ATOM   2413 C C    . GLN B 1 59  ? 130.379 120.000 78.612  1.00 67.61  ? 59  GLN A C    1 
ATOM   2414 O O    . GLN B 1 59  ? 130.092 119.794 77.426  1.00 67.39  ? 59  GLN A O    1 
ATOM   2415 C CB   . GLN B 1 59  ? 132.473 119.031 79.596  1.00 66.39  ? 59  GLN A CB   1 
ATOM   2416 C CG   . GLN B 1 59  ? 133.314 118.251 78.598  1.00 69.92  ? 59  GLN A CG   1 
ATOM   2417 C CD   . GLN B 1 59  ? 132.492 117.672 77.465  1.00 73.19  ? 59  GLN A CD   1 
ATOM   2418 O OE1  . GLN B 1 59  ? 131.371 117.205 77.669  1.00 70.63  ? 59  GLN A OE1  1 
ATOM   2419 N NE2  . GLN B 1 59  ? 133.046 117.699 76.258  1.00 70.68  ? 59  GLN A NE2  1 
ATOM   2420 N N    . PHE B 1 60  ? 129.454 119.986 79.579  1.00 67.06  ? 60  PHE A N    1 
ATOM   2421 C CA   . PHE B 1 60  ? 128.055 119.747 79.234  1.00 66.30  ? 60  PHE A CA   1 
ATOM   2422 C C    . PHE B 1 60  ? 127.505 120.857 78.350  1.00 65.30  ? 60  PHE A C    1 
ATOM   2423 O O    . PHE B 1 60  ? 126.763 120.592 77.399  1.00 60.36  ? 60  PHE A O    1 
ATOM   2424 C CB   . PHE B 1 60  ? 127.194 119.598 80.486  1.00 62.35  ? 60  PHE A CB   1 
ATOM   2425 C CG   . PHE B 1 60  ? 125.757 119.264 80.178  1.00 62.86  ? 60  PHE A CG   1 
ATOM   2426 C CD1  . PHE B 1 60  ? 125.376 117.953 79.938  1.00 62.76  ? 60  PHE A CD1  1 
ATOM   2427 C CD2  . PHE B 1 60  ? 124.794 120.259 80.109  1.00 63.82  ? 60  PHE A CD2  1 
ATOM   2428 C CE1  . PHE B 1 60  ? 124.063 117.641 79.645  1.00 59.59  ? 60  PHE A CE1  1 
ATOM   2429 C CE2  . PHE B 1 60  ? 123.482 119.951 79.817  1.00 59.72  ? 60  PHE A CE2  1 
ATOM   2430 C CZ   . PHE B 1 60  ? 123.114 118.641 79.586  1.00 57.95  ? 60  PHE A CZ   1 
ATOM   2431 N N    . SER B 1 61  ? 127.847 122.113 78.657  1.00 72.32  ? 61  SER A N    1 
ATOM   2432 C CA   . SER B 1 61  ? 127.356 123.225 77.849  1.00 70.47  ? 61  SER A CA   1 
ATOM   2433 C C    . SER B 1 61  ? 127.903 123.164 76.429  1.00 70.19  ? 61  SER A C    1 
ATOM   2434 O O    . SER B 1 61  ? 127.176 123.434 75.468  1.00 69.46  ? 61  SER A O    1 
ATOM   2435 C CB   . SER B 1 61  ? 127.720 124.553 78.510  1.00 70.55  ? 61  SER A CB   1 
ATOM   2436 O OG   . SER B 1 61  ? 127.345 125.646 77.693  1.00 72.64  ? 61  SER A OG   1 
ATOM   2437 N N    . ARG B 1 62  ? 129.182 122.813 76.276  1.00 73.64  ? 62  ARG A N    1 
ATOM   2438 C CA   . ARG B 1 62  ? 129.776 122.781 74.943  1.00 75.37  ? 62  ARG A CA   1 
ATOM   2439 C C    . ARG B 1 62  ? 129.275 121.589 74.132  1.00 75.30  ? 62  ARG A C    1 
ATOM   2440 O O    . ARG B 1 62  ? 129.094 121.697 72.914  1.00 74.86  ? 62  ARG A O    1 
ATOM   2441 C CB   . ARG B 1 62  ? 131.300 122.754 75.046  1.00 75.97  ? 62  ARG A CB   1 
ATOM   2442 C CG   . ARG B 1 62  ? 132.019 122.862 73.709  1.00 75.52  ? 62  ARG A CG   1 
ATOM   2443 C CD   . ARG B 1 62  ? 133.508 122.543 73.809  1.00 75.91  ? 62  ARG A CD   1 
ATOM   2444 N NE   . ARG B 1 62  ? 133.829 121.619 74.894  1.00 78.11  ? 62  ARG A NE   1 
ATOM   2445 C CZ   . ARG B 1 62  ? 134.334 121.981 76.065  1.00 78.00  ? 62  ARG A CZ   1 
ATOM   2446 N NH1  . ARG B 1 62  ? 134.591 123.248 76.346  1.00 75.08  ? 62  ARG A NH1  1 
ATOM   2447 N NH2  . ARG B 1 62  ? 134.589 121.049 76.978  1.00 74.55  ? 62  ARG A NH2  1 
ATOM   2448 N N    . GLY B 1 63  ? 129.051 120.445 74.783  1.00 74.35  ? 63  GLY A N    1 
ATOM   2449 C CA   . GLY B 1 63  ? 128.656 119.256 74.048  1.00 74.98  ? 63  GLY A CA   1 
ATOM   2450 C C    . GLY B 1 63  ? 127.283 119.358 73.410  1.00 75.58  ? 63  GLY A C    1 
ATOM   2451 O O    . GLY B 1 63  ? 127.085 118.918 72.272  1.00 75.54  ? 63  GLY A O    1 
ATOM   2452 N N    . HIS B 1 64  ? 126.313 119.930 74.123  1.00 75.11  ? 64  HIS A N    1 
ATOM   2453 C CA   . HIS B 1 64  ? 124.935 119.993 73.651  1.00 73.32  ? 64  HIS A CA   1 
ATOM   2454 C C    . HIS B 1 64  ? 124.553 121.381 73.146  1.00 73.62  ? 64  HIS A C    1 
ATOM   2455 O O    . HIS B 1 64  ? 123.359 121.680 73.036  1.00 72.13  ? 64  HIS A O    1 
ATOM   2456 C CB   . HIS B 1 64  ? 123.974 119.551 74.756  1.00 74.91  ? 64  HIS A CB   1 
ATOM   2457 C CG   . HIS B 1 64  ? 124.114 118.112 75.140  1.00 73.39  ? 64  HIS A CG   1 
ATOM   2458 N ND1  . HIS B 1 64  ? 124.954 117.689 76.146  1.00 73.20  ? 64  HIS A ND1  1 
ATOM   2459 C CD2  . HIS B 1 64  ? 123.520 116.999 74.649  1.00 72.64  ? 64  HIS A CD2  1 
ATOM   2460 C CE1  . HIS B 1 64  ? 124.871 116.374 76.261  1.00 73.04  ? 64  HIS A CE1  1 
ATOM   2461 N NE2  . HIS B 1 64  ? 124.008 115.931 75.366  1.00 73.69  ? 64  HIS A NE2  1 
ATOM   2462 N N    . GLN B 1 65  ? 125.543 122.223 72.839  1.00 78.65  ? 65  GLN A N    1 
ATOM   2463 C CA   . GLN B 1 65  ? 125.380 123.573 72.298  1.00 78.96  ? 65  GLN A CA   1 
ATOM   2464 C C    . GLN B 1 65  ? 124.231 124.338 72.949  1.00 76.83  ? 65  GLN A C    1 
ATOM   2465 O O    . GLN B 1 65  ? 123.466 125.027 72.265  1.00 72.98  ? 65  GLN A O    1 
ATOM   2466 C CB   . GLN B 1 65  ? 125.207 123.531 70.770  1.00 76.91  ? 65  GLN A CB   1 
ATOM   2467 C CG   . GLN B 1 65  ? 123.998 122.770 70.239  1.00 78.55  ? 65  GLN A CG   1 
ATOM   2468 C CD   . GLN B 1 65  ? 123.979 122.682 68.725  1.00 81.63  ? 65  GLN A CD   1 
ATOM   2469 O OE1  . GLN B 1 65  ? 124.894 123.153 68.052  1.00 79.89  ? 65  GLN A OE1  1 
ATOM   2470 N NE2  . GLN B 1 65  ? 122.927 122.080 68.180  1.00 81.00  ? 65  GLN A NE2  1 
ATOM   2471 N N    . LEU B 1 66  ? 124.113 124.237 74.271  1.00 76.28  ? 66  LEU A N    1 
ATOM   2472 C CA   . LEU B 1 66  ? 123.120 125.000 75.011  1.00 74.08  ? 66  LEU A CA   1 
ATOM   2473 C C    . LEU B 1 66  ? 123.701 126.350 75.426  1.00 75.34  ? 66  LEU A C    1 
ATOM   2474 O O    . LEU B 1 66  ? 124.845 126.687 75.116  1.00 76.93  ? 66  LEU A O    1 
ATOM   2475 C CB   . LEU B 1 66  ? 122.638 124.208 76.226  1.00 70.91  ? 66  LEU A CB   1 
ATOM   2476 C CG   . LEU B 1 66  ? 121.781 122.973 75.941  1.00 72.81  ? 66  LEU A CG   1 
ATOM   2477 C CD1  . LEU B 1 66  ? 121.440 122.250 77.234  1.00 72.51  ? 66  LEU A CD1  1 
ATOM   2478 C CD2  . LEU B 1 66  ? 120.518 123.355 75.189  1.00 74.34  ? 66  LEU A CD2  1 
ATOM   2479 N N    . SER B 1 67  ? 122.886 127.128 76.146  1.00 75.40  ? 67  SER A N    1 
ATOM   2480 C CA   . SER B 1 67  ? 123.348 128.447 76.650  1.00 73.46  ? 67  SER A CA   1 
ATOM   2481 C C    . SER B 1 67  ? 123.428 128.396 78.179  1.00 76.01  ? 67  SER A C    1 
ATOM   2482 O O    . SER B 1 67  ? 122.757 127.531 78.776  1.00 78.30  ? 67  SER A O    1 
ATOM   2483 C CB   . SER B 1 67  ? 122.437 129.553 76.189  1.00 73.12  ? 67  SER A CB   1 
ATOM   2484 O OG   . SER B 1 67  ? 121.830 130.203 77.296  1.00 76.39  ? 67  SER A OG   1 
ATOM   2485 N N    . ARG B 1 68  ? 124.209 129.293 78.786  1.00 75.10  ? 68  ARG A N    1 
ATOM   2486 C CA   . ARG B 1 68  ? 124.389 129.262 80.263  1.00 73.92  ? 68  ARG A CA   1 
ATOM   2487 C C    . ARG B 1 68  ? 123.098 129.730 80.947  1.00 74.85  ? 68  ARG A C    1 
ATOM   2488 O O    . ARG B 1 68  ? 122.736 129.127 81.975  1.00 76.39  ? 68  ARG A O    1 
ATOM   2489 C CB   . ARG B 1 68  ? 125.599 130.108 80.675  1.00 74.52  ? 68  ARG A CB   1 
ATOM   2490 C CG   . ARG B 1 68  ? 126.941 129.468 80.347  1.00 73.87  ? 68  ARG A CG   1 
ATOM   2491 C CD   . ARG B 1 68  ? 127.549 128.701 81.508  1.00 72.07  ? 68  ARG A CD   1 
ATOM   2492 N NE   . ARG B 1 68  ? 128.617 127.799 81.095  1.00 74.86  ? 68  ARG A NE   1 
ATOM   2493 C CZ   . ARG B 1 68  ? 129.814 127.729 81.668  1.00 75.82  ? 68  ARG A CZ   1 
ATOM   2494 N NH1  . ARG B 1 68  ? 130.759 126.975 81.136  1.00 73.99  ? 68  ARG A NH1  1 
ATOM   2495 N NH2  . ARG B 1 68  ? 130.062 128.415 82.771  1.00 74.53  ? 68  ARG A NH2  1 
ATOM   2496 N N    . ASP B 1 69  ? 122.425 130.749 80.400  1.00 73.89  ? 69  ASP A N    1 
ATOM   2497 C CA   . ASP B 1 69  ? 121.235 131.274 81.067  1.00 74.82  ? 69  ASP A CA   1 
ATOM   2498 C C    . ASP B 1 69  ? 120.145 130.217 81.146  1.00 75.53  ? 69  ASP A C    1 
ATOM   2499 O O    . ASP B 1 69  ? 119.441 130.106 82.159  1.00 76.00  ? 69  ASP A O    1 
ATOM   2500 C CB   . ASP B 1 69  ? 120.735 132.520 80.341  1.00 76.85  ? 69  ASP A CB   1 
ATOM   2501 C CG   . ASP B 1 69  ? 121.727 133.665 80.401  1.00 79.11  ? 69  ASP A CG   1 
ATOM   2502 O OD1  . ASP B 1 69  ? 122.491 133.739 81.386  1.00 78.53  ? 69  ASP A OD1  1 
ATOM   2503 O OD2  . ASP B 1 69  ? 121.742 134.489 79.463  1.00 78.97  ? 69  ASP A OD2  1 
ATOM   2504 N N    . GLU B 1 70  ? 119.981 129.437 80.076  1.00 68.19  ? 70  GLU A N    1 
ATOM   2505 C CA   . GLU B 1 70  ? 118.988 128.370 80.080  1.00 67.06  ? 70  GLU A CA   1 
ATOM   2506 C C    . GLU B 1 70  ? 119.329 127.339 81.145  1.00 68.84  ? 70  GLU A C    1 
ATOM   2507 O O    . GLU B 1 70  ? 118.445 126.856 81.864  1.00 69.46  ? 70  GLU A O    1 
ATOM   2508 C CB   . GLU B 1 70  ? 118.907 127.722 78.701  1.00 66.46  ? 70  GLU A CB   1 
ATOM   2509 C CG   . GLU B 1 70  ? 118.749 128.716 77.564  1.00 68.71  ? 70  GLU A CG   1 
ATOM   2510 C CD   . GLU B 1 70  ? 118.736 128.047 76.207  1.00 72.43  ? 70  GLU A CD   1 
ATOM   2511 O OE1  . GLU B 1 70  ? 118.713 126.800 76.158  1.00 75.17  ? 70  GLU A OE1  1 
ATOM   2512 O OE2  . GLU B 1 70  ? 118.747 128.769 75.188  1.00 71.19  ? 70  GLU A OE2  1 
ATOM   2513 N N    . LEU B 1 71  ? 120.611 126.988 81.255  1.00 60.49  ? 71  LEU A N    1 
ATOM   2514 C CA   . LEU B 1 71  ? 121.036 126.051 82.288  1.00 58.94  ? 71  LEU A CA   1 
ATOM   2515 C C    . LEU B 1 71  ? 120.823 126.632 83.680  1.00 57.87  ? 71  LEU A C    1 
ATOM   2516 O O    . LEU B 1 71  ? 120.449 125.906 84.604  1.00 59.63  ? 71  LEU A O    1 
ATOM   2517 C CB   . LEU B 1 71  ? 122.502 125.676 82.077  1.00 58.06  ? 71  LEU A CB   1 
ATOM   2518 C CG   . LEU B 1 71  ? 122.778 124.595 81.028  1.00 57.77  ? 71  LEU A CG   1 
ATOM   2519 C CD1  . LEU B 1 71  ? 124.181 124.036 81.190  1.00 59.77  ? 71  LEU A CD1  1 
ATOM   2520 C CD2  . LEU B 1 71  ? 121.744 123.483 81.106  1.00 57.13  ? 71  LEU A CD2  1 
ATOM   2521 N N    . ARG B 1 72  ? 121.054 127.939 83.855  1.00 57.02  ? 72  ARG A N    1 
ATOM   2522 C CA   . ARG B 1 72  ? 120.792 128.550 85.154  1.00 56.74  ? 72  ARG A CA   1 
ATOM   2523 C C    . ARG B 1 72  ? 119.313 128.472 85.517  1.00 60.16  ? 72  ARG A C    1 
ATOM   2524 O O    . ARG B 1 72  ? 118.963 128.171 86.666  1.00 61.14  ? 72  ARG A O    1 
ATOM   2525 C CB   . ARG B 1 72  ? 121.262 130.005 85.163  1.00 58.81  ? 72  ARG A CB   1 
ATOM   2526 C CG   . ARG B 1 72  ? 122.765 130.186 85.067  1.00 63.65  ? 72  ARG A CG   1 
ATOM   2527 C CD   . ARG B 1 72  ? 123.433 130.048 86.425  1.00 65.67  ? 72  ARG A CD   1 
ATOM   2528 N NE   . ARG B 1 72  ? 122.974 131.071 87.358  1.00 66.24  ? 72  ARG A NE   1 
ATOM   2529 C CZ   . ARG B 1 72  ? 123.369 132.336 87.335  1.00 65.09  ? 72  ARG A CZ   1 
ATOM   2530 N NH1  . ARG B 1 72  ? 124.244 132.772 86.443  1.00 62.27  ? 72  ARG A NH1  1 
ATOM   2531 N NH2  . ARG B 1 72  ? 122.873 133.184 88.231  1.00 64.02  ? 72  ARG A NH2  1 
ATOM   2532 N N    . GLY B 1 73  ? 118.430 128.739 84.554  1.00 56.30  ? 73  GLY A N    1 
ATOM   2533 C CA   . GLY B 1 73  ? 117.002 128.616 84.818  1.00 53.48  ? 73  GLY A CA   1 
ATOM   2534 C C    . GLY B 1 73  ? 116.580 127.192 85.133  1.00 51.19  ? 73  GLY A C    1 
ATOM   2535 O O    . GLY B 1 73  ? 115.792 126.952 86.058  1.00 52.32  ? 73  GLY A O    1 
ATOM   2536 N N    . PHE B 1 74  ? 117.110 126.228 84.375  1.00 43.38  ? 74  PHE A N    1 
ATOM   2537 C CA   . PHE B 1 74  ? 116.823 124.820 84.634  1.00 38.65  ? 74  PHE A CA   1 
ATOM   2538 C C    . PHE B 1 74  ? 117.290 124.416 86.026  1.00 42.86  ? 74  PHE A C    1 
ATOM   2539 O O    . PHE B 1 74  ? 116.577 123.714 86.752  1.00 42.35  ? 74  PHE A O    1 
ATOM   2540 C CB   . PHE B 1 74  ? 117.483 123.957 83.555  1.00 35.63  ? 74  PHE A CB   1 
ATOM   2541 C CG   . PHE B 1 74  ? 117.102 122.504 83.613  1.00 40.32  ? 74  PHE A CG   1 
ATOM   2542 C CD1  . PHE B 1 74  ? 115.798 122.109 83.368  1.00 37.92  ? 74  PHE A CD1  1 
ATOM   2543 C CD2  . PHE B 1 74  ? 118.050 121.534 83.888  1.00 41.72  ? 74  PHE A CD2  1 
ATOM   2544 C CE1  . PHE B 1 74  ? 115.444 120.777 83.413  1.00 38.68  ? 74  PHE A CE1  1 
ATOM   2545 C CE2  . PHE B 1 74  ? 117.701 120.198 83.933  1.00 41.97  ? 74  PHE A CE2  1 
ATOM   2546 C CZ   . PHE B 1 74  ? 116.397 119.819 83.696  1.00 40.99  ? 74  PHE A CZ   1 
ATOM   2547 N N    . LEU B 1 75  ? 118.482 124.863 86.424  1.00 44.78  ? 75  LEU A N    1 
ATOM   2548 C CA   . LEU B 1 75  ? 119.004 124.520 87.742  1.00 40.17  ? 75  LEU A CA   1 
ATOM   2549 C C    . LEU B 1 75  ? 118.220 125.202 88.853  1.00 42.89  ? 75  LEU A C    1 
ATOM   2550 O O    . LEU B 1 75  ? 118.074 124.633 89.934  1.00 44.90  ? 75  LEU A O    1 
ATOM   2551 C CB   . LEU B 1 75  ? 120.487 124.879 87.832  1.00 38.43  ? 75  LEU A CB   1 
ATOM   2552 C CG   . LEU B 1 75  ? 121.430 124.040 86.969  1.00 35.73  ? 75  LEU A CG   1 
ATOM   2553 C CD1  . LEU B 1 75  ? 122.866 124.514 87.113  1.00 37.31  ? 75  LEU A CD1  1 
ATOM   2554 C CD2  . LEU B 1 75  ? 121.310 122.568 87.316  1.00 38.23  ? 75  LEU A CD2  1 
ATOM   2555 N N    . ARG B 1 76  ? 117.715 126.414 88.615  1.00 42.14  ? 76  ARG A N    1 
ATOM   2556 C CA   . ARG B 1 76  ? 116.853 127.054 89.606  1.00 40.58  ? 76  ARG A CA   1 
ATOM   2557 C C    . ARG B 1 76  ? 115.556 126.275 89.789  1.00 44.67  ? 76  ARG A C    1 
ATOM   2558 O O    . ARG B 1 76  ? 115.093 126.065 90.921  1.00 42.59  ? 76  ARG A O    1 
ATOM   2559 C CB   . ARG B 1 76  ? 116.565 128.496 89.186  1.00 39.27  ? 76  ARG A CB   1 
ATOM   2560 C CG   . ARG B 1 76  ? 116.160 129.416 90.321  1.00 47.55  ? 76  ARG A CG   1 
ATOM   2561 C CD   . ARG B 1 76  ? 115.754 130.781 89.794  1.00 48.02  ? 76  ARG A CD   1 
ATOM   2562 N NE   . ARG B 1 76  ? 116.749 131.329 88.880  1.00 46.03  ? 76  ARG A NE   1 
ATOM   2563 C CZ   . ARG B 1 76  ? 117.782 132.070 89.253  1.00 48.75  ? 76  ARG A CZ   1 
ATOM   2564 N NH1  . ARG B 1 76  ? 117.994 132.372 90.524  1.00 47.01  ? 76  ARG A NH1  1 
ATOM   2565 N NH2  . ARG B 1 76  ? 118.630 132.515 88.327  1.00 48.24  ? 76  ARG A NH2  1 
ATOM   2566 N N    . HIS B 1 77  ? 114.954 125.828 88.680  1.00 43.50  ? 77  HIS A N    1 
ATOM   2567 C CA   . HIS B 1 77  ? 113.761 124.988 88.779  1.00 32.82  ? 77  HIS A CA   1 
ATOM   2568 C C    . HIS B 1 77  ? 114.060 123.693 89.524  1.00 37.14  ? 77  HIS A C    1 
ATOM   2569 O O    . HIS B 1 77  ? 113.259 123.241 90.351  1.00 38.72  ? 77  HIS A O    1 
ATOM   2570 C CB   . HIS B 1 77  ? 113.204 124.694 87.387  1.00 33.77  ? 77  HIS A CB   1 
ATOM   2571 C CG   . HIS B 1 77  ? 112.427 125.832 86.801  1.00 39.14  ? 77  HIS A CG   1 
ATOM   2572 N ND1  . HIS B 1 77  ? 111.865 125.781 85.545  1.00 40.35  ? 77  HIS A ND1  1 
ATOM   2573 C CD2  . HIS B 1 77  ? 112.107 127.045 87.307  1.00 39.02  ? 77  HIS A CD2  1 
ATOM   2574 C CE1  . HIS B 1 77  ? 111.241 126.918 85.297  1.00 38.30  ? 77  HIS A CE1  1 
ATOM   2575 N NE2  . HIS B 1 77  ? 111.373 127.702 86.352  1.00 41.87  ? 77  HIS A NE2  1 
ATOM   2576 N N    . TYR B 1 78  ? 115.220 123.091 89.252  1.00 39.52  ? 78  TYR A N    1 
ATOM   2577 C CA   . TYR B 1 78  ? 115.539 121.774 89.869  1.00 34.61  ? 78  TYR A CA   1 
ATOM   2578 C C    . TYR B 1 78  ? 115.581 121.881 91.399  1.00 36.02  ? 78  TYR A C    1 
ATOM   2579 O O    . TYR B 1 78  ? 114.967 121.027 92.068  1.00 47.68  ? 78  TYR A O    1 
ATOM   2580 C CB   . TYR B 1 78  ? 116.865 121.233 89.330  1.00 38.65  ? 78  TYR A CB   1 
ATOM   2581 C CG   . TYR B 1 78  ? 117.340 119.975 90.012  1.00 37.98  ? 78  TYR A CG   1 
ATOM   2582 C CD1  . TYR B 1 78  ? 116.570 118.825 90.006  1.00 36.01  ? 78  TYR A CD1  1 
ATOM   2583 C CD2  . TYR B 1 78  ? 118.555 119.937 90.675  1.00 36.85  ? 78  TYR A CD2  1 
ATOM   2584 C CE1  . TYR B 1 78  ? 116.995 117.666 90.635  1.00 32.52  ? 78  TYR A CE1  1 
ATOM   2585 C CE2  . TYR B 1 78  ? 118.997 118.787 91.308  1.00 40.40  ? 78  TYR A CE2  1 
ATOM   2586 C CZ   . TYR B 1 78  ? 118.214 117.647 91.288  1.00 40.97  ? 78  TYR A CZ   1 
ATOM   2587 O OH   . TYR B 1 78  ? 118.644 116.504 91.914  1.00 44.71  ? 78  TYR A OH   1 
ATOM   2588 N N    . GLU B 1 79  ? 116.283 122.882 91.937  1.00 38.22  ? 79  GLU A N    1 
ATOM   2589 C CA   . GLU B 1 79  ? 116.454 122.991 93.413  1.00 39.32  ? 79  GLU A CA   1 
ATOM   2590 C C    . GLU B 1 79  ? 115.095 123.080 94.118  1.00 42.96  ? 79  GLU A C    1 
ATOM   2591 O O    . GLU B 1 79  ? 114.972 122.506 95.217  1.00 44.41  ? 79  GLU A O    1 
ATOM   2592 C CB   . GLU B 1 79  ? 117.309 124.213 93.753  1.00 40.55  ? 79  GLU A CB   1 
ATOM   2593 C CG   . GLU B 1 79  ? 118.691 124.175 93.126  1.00 47.50  ? 79  GLU A CG   1 
ATOM   2594 C CD   . GLU B 1 79  ? 119.267 125.538 92.787  1.00 50.63  ? 79  GLU A CD   1 
ATOM   2595 O OE1  . GLU B 1 79  ? 118.476 126.457 92.496  1.00 49.19  ? 79  GLU A OE1  1 
ATOM   2596 O OE2  . GLU B 1 79  ? 120.506 125.679 92.817  1.00 53.41  ? 79  GLU A OE2  1 
ATOM   2597 N N    . GLU B 1 80  ? 114.163 123.850 93.588  1.00 42.29  ? 80  GLU A N    1 
ATOM   2598 C CA   . GLU B 1 80  ? 112.816 124.013 94.168  1.00 39.14  ? 80  GLU A CA   1 
ATOM   2599 C C    . GLU B 1 80  ? 112.151 122.662 94.330  1.00 41.61  ? 80  GLU A C    1 
ATOM   2600 O O    . GLU B 1 80  ? 111.385 122.538 95.256  1.00 38.99  ? 80  GLU A O    1 
ATOM   2601 C CB   . GLU B 1 80  ? 112.088 124.922 93.203  1.00 37.81  ? 80  GLU A CB   1 
ATOM   2602 C CG   . GLU B 1 80  ? 110.694 125.322 93.599  1.00 42.14  ? 80  GLU A CG   1 
ATOM   2603 C CD   . GLU B 1 80  ? 110.057 126.118 92.477  1.00 50.31  ? 80  GLU A CD   1 
ATOM   2604 O OE1  . GLU B 1 80  ? 110.783 126.888 91.830  1.00 48.77  ? 80  GLU A OE1  1 
ATOM   2605 O OE2  . GLU B 1 80  ? 108.853 125.949 92.242  1.00 51.96  ? 80  GLU A OE2  1 
ATOM   2606 N N    . ALA B 1 81  ? 112.442 121.715 93.435  1.00 44.29  ? 81  ALA A N    1 
ATOM   2607 C CA   . ALA B 1 81  ? 111.860 120.357 93.526  1.00 36.85  ? 81  ALA A CA   1 
ATOM   2608 C C    . ALA B 1 81  ? 112.522 119.602 94.684  1.00 35.35  ? 81  ALA A C    1 
ATOM   2609 O O    . ALA B 1 81  ? 111.801 118.916 95.433  1.00 39.22  ? 81  ALA A O    1 
ATOM   2610 C CB   . ALA B 1 81  ? 112.041 119.637 92.214  1.00 36.09  ? 81  ALA A CB   1 
ATOM   2611 N N    . THR B 1 82  ? 113.843 119.736 94.824  1.00 40.28  ? 82  THR A N    1 
ATOM   2612 C CA   . THR B 1 82  ? 114.582 119.036 95.910  1.00 39.72  ? 82  THR A CA   1 
ATOM   2613 C C    . THR B 1 82  ? 113.978 119.414 97.267  1.00 43.47  ? 82  THR A C    1 
ATOM   2614 O O    . THR B 1 82  ? 114.009 118.564 98.178  1.00 42.16  ? 82  THR A O    1 
ATOM   2615 C CB   . THR B 1 82  ? 116.082 119.347 95.841  1.00 40.84  ? 82  THR A CB   1 
ATOM   2616 O OG1  . THR B 1 82  ? 116.249 120.760 95.961  1.00 41.33  ? 82  THR A OG1  1 
ATOM   2617 C CG2  . THR B 1 82  ? 116.726 118.868 94.559  1.00 48.02  ? 82  THR A CG2  1 
ATOM   2618 N N    . ARG B 1 83  ? 113.451 120.636 97.391  1.00 50.97  ? 83  ARG A N    1 
ATOM   2619 C CA   . ARG B 1 83  ? 112.855 121.093 98.658  1.00 44.69  ? 83  ARG A CA   1 
ATOM   2620 C C    . ARG B 1 83  ? 111.503 120.405 98.847  1.00 45.53  ? 83  ARG A C    1 
ATOM   2621 O O    . ARG B 1 83  ? 111.172 120.129 99.976  1.00 48.42  ? 83  ARG A O    1 
ATOM   2622 C CB   . ARG B 1 83  ? 112.710 122.606 98.634  1.00 45.53  ? 83  ARG A CB   1 
ATOM   2623 C CG   . ARG B 1 83  ? 113.975 123.402 98.374  1.00 48.85  ? 83  ARG A CG   1 
ATOM   2624 C CD   . ARG B 1 83  ? 113.654 124.867 98.606  1.00 53.91  ? 83  ARG A CD   1 
ATOM   2625 N NE   . ARG B 1 83  ? 114.435 125.802 97.807  1.00 54.81  ? 83  ARG A NE   1 
ATOM   2626 C CZ   . ARG B 1 83  ? 113.930 126.608 96.880  1.00 56.34  ? 83  ARG A CZ   1 
ATOM   2627 N NH1  . ARG B 1 83  ? 112.629 126.822 96.825  1.00 54.04  ? 83  ARG A NH1  1 
ATOM   2628 N NH2  . ARG B 1 83  ? 114.730 127.193 96.007  1.00 48.35  ? 83  ARG A NH2  1 
ATOM   2629 N N    . ALA B 1 84  ? 110.733 120.159 97.804  1.00 48.09  ? 84  ALA A N    1 
ATOM   2630 C CA   . ALA B 1 84  ? 109.496 119.375 97.902  1.00 42.62  ? 84  ALA A CA   1 
ATOM   2631 C C    . ALA B 1 84  ? 109.878 117.941 98.198  1.00 37.45  ? 84  ALA A C    1 
ATOM   2632 O O    . ALA B 1 84  ? 109.025 117.202 98.645  1.00 45.96  ? 84  ALA A O    1 
ATOM   2633 C CB   . ALA B 1 84  ? 108.795 119.431 96.597  1.00 45.03  ? 84  ALA A CB   1 
ATOM   2634 N N    . GLY B 1 85  ? 111.151 117.589 97.991  1.00 41.62  ? 85  GLY A N    1 
ATOM   2635 C CA   . GLY B 1 85  ? 111.629 116.229 98.308  1.00 39.16  ? 85  GLY A CA   1 
ATOM   2636 C C    . GLY B 1 85  ? 112.036 115.471 97.058  1.00 43.25  ? 85  GLY A C    1 
ATOM   2637 O O    . GLY B 1 85  ? 112.351 114.270 97.174  1.00 46.93  ? 85  GLY A O    1 
ATOM   2638 N N    . ILE B 1 86  ? 112.032 116.145 95.904  1.00 45.08  ? 86  ILE A N    1 
ATOM   2639 C CA   . ILE B 1 86  ? 112.360 115.462 94.617  1.00 34.73  ? 86  ILE A CA   1 
ATOM   2640 C C    . ILE B 1 86  ? 113.852 115.121 94.598  1.00 38.76  ? 86  ILE A C    1 
ATOM   2641 O O    . ILE B 1 86  ? 114.674 116.055 94.673  1.00 45.15  ? 86  ILE A O    1 
ATOM   2642 C CB   . ILE B 1 86  ? 111.952 116.326 93.408  1.00 38.81  ? 86  ILE A CB   1 
ATOM   2643 C CG1  . ILE B 1 86  ? 110.433 116.356 93.224  1.00 40.00  ? 86  ILE A CG1  1 
ATOM   2644 C CG2  . ILE B 1 86  ? 112.665 115.861 92.147  1.00 38.99  ? 86  ILE A CG2  1 
ATOM   2645 C CD1  . ILE B 1 86  ? 109.817 114.994 93.011  1.00 42.50  ? 86  ILE A CD1  1 
ATOM   2646 N N    . ARG B 1 87  ? 114.181 113.831 94.509  1.00 48.68  ? 87  ARG A N    1 
ATOM   2647 C CA   . ARG B 1 87  ? 115.574 113.398 94.443  1.00 50.31  ? 87  ARG A CA   1 
ATOM   2648 C C    . ARG B 1 87  ? 115.800 112.626 93.144  1.00 48.57  ? 87  ARG A C    1 
ATOM   2649 O O    . ARG B 1 87  ? 114.887 112.442 92.336  1.00 51.59  ? 87  ARG A O    1 
ATOM   2650 C CB   . ARG B 1 87  ? 115.921 112.542 95.668  1.00 48.31  ? 87  ARG A CB   1 
ATOM   2651 C CG   . ARG B 1 87  ? 117.374 112.588 96.094  1.00 49.33  ? 87  ARG A CG   1 
ATOM   2652 C CD   . ARG B 1 87  ? 117.717 113.921 96.735  1.00 50.48  ? 87  ARG A CD   1 
ATOM   2653 N NE   . ARG B 1 87  ? 116.620 114.446 97.541  1.00 47.17  ? 87  ARG A NE   1 
ATOM   2654 C CZ   . ARG B 1 87  ? 116.756 115.371 98.480  1.00 52.06  ? 87  ARG A CZ   1 
ATOM   2655 N NH1  . ARG B 1 87  ? 117.938 115.891 98.768  1.00 52.22  ? 87  ARG A NH1  1 
ATOM   2656 N NH2  . ARG B 1 87  ? 115.681 115.784 99.145  1.00 49.46  ? 87  ARG A NH2  1 
ATOM   2657 N N    . VAL B 1 88  ? 117.035 112.164 92.943  1.00 53.34  ? 88  VAL A N    1 
ATOM   2658 C CA   . VAL B 1 88  ? 117.390 111.449 91.721  1.00 57.56  ? 88  VAL A CA   1 
ATOM   2659 C C    . VAL B 1 88  ? 117.324 109.929 91.880  1.00 59.33  ? 88  VAL A C    1 
ATOM   2660 O O    . VAL B 1 88  ? 117.139 109.222 90.877  1.00 55.88  ? 88  VAL A O    1 
ATOM   2661 C CB   . VAL B 1 88  ? 118.791 111.889 91.235  1.00 53.69  ? 88  VAL A CB   1 
ATOM   2662 C CG1  . VAL B 1 88  ? 119.258 111.083 90.031  1.00 51.80  ? 88  VAL A CG1  1 
ATOM   2663 C CG2  . VAL B 1 88  ? 118.785 113.365 90.887  1.00 50.03  ? 88  VAL A CG2  1 
ATOM   2664 N N    . ASP B 1 89  ? 117.392 109.412 93.104  1.00 60.32  ? 89  ASP A N    1 
ATOM   2665 C CA   . ASP B 1 89  ? 117.367 107.969 93.352  1.00 58.11  ? 89  ASP A CA   1 
ATOM   2666 C C    . ASP B 1 89  ? 116.239 107.636 94.323  1.00 61.69  ? 89  ASP A C    1 
ATOM   2667 O O    . ASP B 1 89  ? 116.460 107.544 95.532  1.00 68.66  ? 89  ASP A O    1 
ATOM   2668 C CB   . ASP B 1 89  ? 118.733 107.497 93.888  1.00 58.71  ? 89  ASP A CB   1 
ATOM   2669 C CG   . ASP B 1 89  ? 119.842 107.623 92.863  1.00 65.25  ? 89  ASP A CG   1 
ATOM   2670 O OD1  . ASP B 1 89  ? 119.541 107.596 91.651  1.00 67.62  ? 89  ASP A OD1  1 
ATOM   2671 O OD2  . ASP B 1 89  ? 121.018 107.750 93.268  1.00 64.43  ? 89  ASP A OD2  1 
ATOM   2672 N N    . ASN B 1 90  ? 115.029 107.466 93.779  1.00 54.21  ? 90  ASN A N    1 
ATOM   2673 C CA   . ASN B 1 90  ? 113.961 106.663 94.379  1.00 52.66  ? 90  ASN A CA   1 
ATOM   2674 C C    . ASN B 1 90  ? 113.826 106.835 95.889  1.00 55.22  ? 90  ASN A C    1 
ATOM   2675 O O    . ASN B 1 90  ? 114.066 105.887 96.641  1.00 57.57  ? 90  ASN A O    1 
ATOM   2676 C CB   . ASN B 1 90  ? 114.177 105.181 94.063  1.00 57.27  ? 90  ASN A CB   1 
ATOM   2677 C CG   . ASN B 1 90  ? 114.047 104.873 92.585  1.00 61.52  ? 90  ASN A CG   1 
ATOM   2678 O OD1  . ASN B 1 90  ? 113.305 105.540 91.862  1.00 60.75  ? 90  ASN A OD1  1 
ATOM   2679 N ND2  . ASN B 1 90  ? 114.764 103.854 92.129  1.00 57.12  ? 90  ASN A ND2  1 
ATOM   2680 N N    . VAL B 1 91  ? 113.460 108.025 96.342  1.00 43.22  ? 91  VAL A N    1 
ATOM   2681 C CA   . VAL B 1 91  ? 113.236 108.253 97.761  1.00 36.73  ? 91  VAL A CA   1 
ATOM   2682 C C    . VAL B 1 91  ? 111.788 107.939 98.117  1.00 38.96  ? 91  VAL A C    1 
ATOM   2683 O O    . VAL B 1 91  ? 110.893 107.925 97.267  1.00 38.35  ? 91  VAL A O    1 
ATOM   2684 C CB   . VAL B 1 91  ? 113.603 109.694 98.170  1.00 39.64  ? 91  VAL A CB   1 
ATOM   2685 C CG1  . VAL B 1 91  ? 115.100 109.810 98.406  1.00 39.31  ? 91  VAL A CG1  1 
ATOM   2686 C CG2  . VAL B 1 91  ? 113.138 110.679 97.112  1.00 45.08  ? 91  VAL A CG2  1 
ATOM   2687 N N    . ARG B 1 92  ? 111.563 107.674 99.399  1.00 35.94  ? 92  ARG A N    1 
ATOM   2688 C CA   . ARG B 1 92  ? 110.227 107.437 99.913  1.00 30.33  ? 92  ARG A CA   1 
ATOM   2689 C C    . ARG B 1 92  ? 109.403 108.725 99.893  1.00 37.67  ? 92  ARG A C    1 
ATOM   2690 O O    . ARG B 1 92  ? 109.956 109.827 99.943  1.00 47.63  ? 92  ARG A O    1 
ATOM   2691 C CB   . ARG B 1 92  ? 110.307 106.881 101.331 1.00 30.47  ? 92  ARG A CB   1 
ATOM   2692 C CG   . ARG B 1 92  ? 110.871 107.852 102.348 1.00 34.56  ? 92  ARG A CG   1 
ATOM   2693 C CD   . ARG B 1 92  ? 111.118 107.169 103.679 1.00 37.08  ? 92  ARG A CD   1 
ATOM   2694 N NE   . ARG B 1 92  ? 109.877 106.852 104.372 1.00 41.72  ? 92  ARG A NE   1 
ATOM   2695 C CZ   . ARG B 1 92  ? 109.808 106.424 105.623 1.00 37.11  ? 92  ARG A CZ   1 
ATOM   2696 N NH1  . ARG B 1 92  ? 110.896 106.243 106.356 1.00 31.40  ? 92  ARG A NH1  1 
ATOM   2697 N NH2  . ARG B 1 92  ? 108.618 106.170 106.156 1.00 36.44  ? 92  ARG A NH2  1 
ATOM   2698 N N    . PRO B 1 93  ? 108.079 108.616 99.801  1.00 34.81  ? 93  PRO A N    1 
ATOM   2699 C CA   . PRO B 1 93  ? 107.238 109.818 99.796  1.00 26.54  ? 93  PRO A CA   1 
ATOM   2700 C C    . PRO B 1 93  ? 107.286 110.564 101.123 1.00 27.59  ? 93  PRO A C    1 
ATOM   2701 O O    . PRO B 1 93  ? 107.453 109.973 102.192 1.00 37.32  ? 93  PRO A O    1 
ATOM   2702 C CB   . PRO B 1 93  ? 105.834 109.270 99.518  1.00 22.21  ? 93  PRO A CB   1 
ATOM   2703 C CG   . PRO B 1 93  ? 105.892 107.842 99.931  1.00 30.05  ? 93  PRO A CG   1 
ATOM   2704 C CD   . PRO B 1 93  ? 107.284 107.389 99.618  1.00 35.64  ? 93  PRO A CD   1 
ATOM   2705 N N    . ARG B 1 94  ? 107.145 111.881 101.035 1.00 30.79  ? 94  ARG A N    1 
ATOM   2706 C CA   . ARG B 1 94  ? 106.973 112.739 102.197 1.00 30.60  ? 94  ARG A CA   1 
ATOM   2707 C C    . ARG B 1 94  ? 105.505 112.825 102.610 1.00 42.30  ? 94  ARG A C    1 
ATOM   2708 O O    . ARG B 1 94  ? 104.595 112.439 101.873 1.00 50.70  ? 94  ARG A O    1 
ATOM   2709 C CB   . ARG B 1 94  ? 107.520 114.138 101.915 1.00 29.89  ? 94  ARG A CB   1 
ATOM   2710 C CG   . ARG B 1 94  ? 108.975 114.321 102.293 1.00 28.48  ? 94  ARG A CG   1 
ATOM   2711 C CD   . ARG B 1 94  ? 109.919 113.893 101.186 1.00 29.51  ? 94  ARG A CD   1 
ATOM   2712 N NE   . ARG B 1 94  ? 111.287 113.811 101.680 1.00 32.21  ? 94  ARG A NE   1 
ATOM   2713 C CZ   . ARG B 1 94  ? 111.882 112.686 102.049 1.00 34.20  ? 94  ARG A CZ   1 
ATOM   2714 N NH1  . ARG B 1 94  ? 111.281 111.514 101.918 1.00 29.81  ? 94  ARG A NH1  1 
ATOM   2715 N NH2  . ARG B 1 94  ? 113.110 112.737 102.553 1.00 38.35  ? 94  ARG A NH2  1 
ATOM   2716 N N    . TRP B 1 95  ? 105.288 113.332 103.824 1.00 25.64  ? 95  TRP A N    1 
ATOM   2717 C CA   . TRP B 1 95  ? 103.972 113.741 104.321 1.00 19.71  ? 95  TRP A CA   1 
ATOM   2718 C C    . TRP B 1 95  ? 102.911 112.645 104.220 1.00 24.53  ? 95  TRP A C    1 
ATOM   2719 O O    . TRP B 1 95  ? 101.712 112.930 104.299 1.00 37.45  ? 95  TRP A O    1 
ATOM   2720 C CB   . TRP B 1 95  ? 103.490 115.018 103.624 1.00 12.21  ? 95  TRP A CB   1 
ATOM   2721 C CG   . TRP B 1 95  ? 104.448 116.168 103.771 1.00 18.32  ? 95  TRP A CG   1 
ATOM   2722 C CD1  . TRP B 1 95  ? 105.025 116.884 102.768 1.00 23.16  ? 95  TRP A CD1  1 
ATOM   2723 C CD2  . TRP B 1 95  ? 104.921 116.737 104.998 1.00 21.82  ? 95  TRP A CD2  1 
ATOM   2724 N NE1  . TRP B 1 95  ? 105.836 117.862 103.292 1.00 22.51  ? 95  TRP A NE1  1 
ATOM   2725 C CE2  . TRP B 1 95  ? 105.788 117.793 104.660 1.00 24.10  ? 95  TRP A CE2  1 
ATOM   2726 C CE3  . TRP B 1 95  ? 104.695 116.458 106.351 1.00 17.75  ? 95  TRP A CE3  1 
ATOM   2727 C CZ2  . TRP B 1 95  ? 106.433 118.568 105.624 1.00 22.93  ? 95  TRP A CZ2  1 
ATOM   2728 C CZ3  . TRP B 1 95  ? 105.333 117.227 107.303 1.00 15.79  ? 95  TRP A CZ3  1 
ATOM   2729 C CH2  . TRP B 1 95  ? 106.193 118.271 106.938 1.00 18.56  ? 95  TRP A CH2  1 
ATOM   2730 N N    . ASP B 1 96  ? 103.310 111.389 104.032 1.00 17.27  ? 96  ASP A N    1 
ATOM   2731 C CA   . ASP B 1 96  ? 102.426 110.301 104.417 1.00 16.53  ? 96  ASP A CA   1 
ATOM   2732 C C    . ASP B 1 96  ? 102.543 110.089 105.925 1.00 31.80  ? 96  ASP A C    1 
ATOM   2733 O O    . ASP B 1 96  ? 103.328 110.753 106.607 1.00 30.86  ? 96  ASP A O    1 
ATOM   2734 C CB   . ASP B 1 96  ? 102.763 109.030 103.637 1.00 22.24  ? 96  ASP A CB   1 
ATOM   2735 C CG   . ASP B 1 96  ? 104.079 108.414 104.066 1.00 39.99  ? 96  ASP A CG   1 
ATOM   2736 O OD1  . ASP B 1 96  ? 105.075 109.156 104.197 1.00 42.62  ? 96  ASP A OD1  1 
ATOM   2737 O OD2  . ASP B 1 96  ? 104.117 107.181 104.262 1.00 43.45  ? 96  ASP A OD2  1 
ATOM   2738 N N    . PHE B 1 97  ? 101.748 109.163 106.461 1.00 29.62  ? 97  PHE A N    1 
ATOM   2739 C CA   . PHE B 1 97  ? 101.693 109.002 107.912 1.00 22.96  ? 97  PHE A CA   1 
ATOM   2740 C C    . PHE B 1 97  ? 103.051 108.610 108.485 1.00 26.86  ? 97  PHE A C    1 
ATOM   2741 O O    . PHE B 1 97  ? 103.476 109.144 109.518 1.00 32.00  ? 97  PHE A O    1 
ATOM   2742 C CB   . PHE B 1 97  ? 100.632 107.974 108.299 1.00 22.43  ? 97  PHE A CB   1 
ATOM   2743 C CG   . PHE B 1 97  ? 100.370 107.921 109.774 1.00 27.10  ? 97  PHE A CG   1 
ATOM   2744 C CD1  . PHE B 1 97  ? 99.490  108.809 110.365 1.00 24.71  ? 97  PHE A CD1  1 
ATOM   2745 C CD2  . PHE B 1 97  ? 101.018 106.994 110.575 1.00 27.69  ? 97  PHE A CD2  1 
ATOM   2746 C CE1  . PHE B 1 97  ? 99.255  108.774 111.722 1.00 25.24  ? 97  PHE A CE1  1 
ATOM   2747 C CE2  . PHE B 1 97  ? 100.788 106.952 111.934 1.00 25.11  ? 97  PHE A CE2  1 
ATOM   2748 C CZ   . PHE B 1 97  ? 99.905  107.842 112.509 1.00 26.72  ? 97  PHE A CZ   1 
ATOM   2749 N N    . THR B 1 98  ? 103.748 107.682 107.825 1.00 23.56  ? 98  THR A N    1 
ATOM   2750 C CA   . THR B 1 98  ? 105.067 107.269 108.298 1.00 29.91  ? 98  THR A CA   1 
ATOM   2751 C C    . THR B 1 98  ? 106.098 108.382 108.129 1.00 30.62  ? 98  THR A C    1 
ATOM   2752 O O    . THR B 1 98  ? 106.935 108.597 109.013 1.00 36.71  ? 98  THR A O    1 
ATOM   2753 C CB   . THR B 1 98  ? 105.507 106.007 107.557 1.00 30.31  ? 98  THR A CB   1 
ATOM   2754 O OG1  . THR B 1 98  ? 104.364 105.188 107.296 1.00 24.80  ? 98  THR A OG1  1 
ATOM   2755 C CG2  . THR B 1 98  ? 106.484 105.214 108.412 1.00 36.01  ? 98  THR A CG2  1 
ATOM   2756 N N    . GLY B 1 99  ? 106.062 109.090 106.999 1.00 18.86  ? 99  GLY A N    1 
ATOM   2757 C CA   . GLY B 1 99  ? 106.950 110.229 106.829 1.00 22.28  ? 99  GLY A CA   1 
ATOM   2758 C C    . GLY B 1 99  ? 106.678 111.337 107.827 1.00 25.33  ? 99  GLY A C    1 
ATOM   2759 O O    . GLY B 1 99  ? 107.608 111.963 108.341 1.00 26.33  ? 99  GLY A O    1 
ATOM   2760 N N    . ALA B 1 100 ? 105.402 111.589 108.124 1.00 23.83  ? 100 ALA A N    1 
ATOM   2761 C CA   . ALA B 1 100 ? 105.062 112.576 109.142 1.00 21.71  ? 100 ALA A CA   1 
ATOM   2762 C C    . ALA B 1 100 ? 105.547 112.136 110.519 1.00 22.90  ? 100 ALA A C    1 
ATOM   2763 O O    . ALA B 1 100 ? 105.993 112.965 111.324 1.00 24.60  ? 100 ALA A O    1 
ATOM   2764 C CB   . ALA B 1 100 ? 103.553 112.822 109.150 1.00 22.97  ? 100 ALA A CB   1 
ATOM   2765 N N    . PHE B 1 101 ? 105.452 110.836 110.813 1.00 15.16  ? 101 PHE A N    1 
ATOM   2766 C CA   . PHE B 1 101 ? 105.976 110.317 112.074 1.00 19.69  ? 101 PHE A CA   1 
ATOM   2767 C C    . PHE B 1 101 ? 107.481 110.519 112.173 1.00 21.56  ? 101 PHE A C    1 
ATOM   2768 O O    . PHE B 1 101 ? 107.995 110.950 113.214 1.00 29.57  ? 101 PHE A O    1 
ATOM   2769 C CB   . PHE B 1 101 ? 105.617 108.834 112.204 1.00 18.31  ? 101 PHE A CB   1 
ATOM   2770 C CG   . PHE B 1 101 ? 105.831 108.277 113.580 1.00 25.93  ? 101 PHE A CG   1 
ATOM   2771 C CD1  . PHE B 1 101 ? 104.886 108.460 114.574 1.00 19.98  ? 101 PHE A CD1  1 
ATOM   2772 C CD2  . PHE B 1 101 ? 106.976 107.555 113.878 1.00 23.21  ? 101 PHE A CD2  1 
ATOM   2773 C CE1  . PHE B 1 101 ? 105.080 107.947 115.838 1.00 23.76  ? 101 PHE A CE1  1 
ATOM   2774 C CE2  . PHE B 1 101 ? 107.175 107.038 115.141 1.00 20.95  ? 101 PHE A CE2  1 
ATOM   2775 C CZ   . PHE B 1 101 ? 106.227 107.234 116.122 1.00 27.16  ? 101 PHE A CZ   1 
ATOM   2776 N N    . TYR B 1 102 ? 108.204 110.226 111.089 1.00 12.90  ? 102 TYR A N    1 
ATOM   2777 C CA   . TYR B 1 102 ? 109.642 110.479 111.056 1.00 16.08  ? 102 TYR A CA   1 
ATOM   2778 C C    . TYR B 1 102 ? 109.941 111.961 111.273 1.00 25.20  ? 102 TYR A C    1 
ATOM   2779 O O    . TYR B 1 102 ? 110.859 112.318 112.026 1.00 23.87  ? 102 TYR A O    1 
ATOM   2780 C CB   . TYR B 1 102 ? 110.216 109.996 109.722 1.00 19.98  ? 102 TYR A CB   1 
ATOM   2781 C CG   . TYR B 1 102 ? 111.685 109.624 109.744 1.00 25.77  ? 102 TYR A CG   1 
ATOM   2782 C CD1  . TYR B 1 102 ? 112.537 110.105 110.730 1.00 26.58  ? 102 TYR A CD1  1 
ATOM   2783 C CD2  . TYR B 1 102 ? 112.217 108.787 108.775 1.00 21.63  ? 102 TYR A CD2  1 
ATOM   2784 C CE1  . TYR B 1 102 ? 113.874 109.764 110.749 1.00 27.67  ? 102 TYR A CE1  1 
ATOM   2785 C CE2  . TYR B 1 102 ? 113.554 108.441 108.784 1.00 23.54  ? 102 TYR A CE2  1 
ATOM   2786 C CZ   . TYR B 1 102 ? 114.379 108.931 109.774 1.00 26.45  ? 102 TYR A CZ   1 
ATOM   2787 O OH   . TYR B 1 102 ? 115.710 108.590 109.788 1.00 32.33  ? 102 TYR A OH   1 
ATOM   2788 N N    . PHE B 1 103 ? 109.173 112.838 110.621 1.00 23.13  ? 103 PHE A N    1 
ATOM   2789 C CA   . PHE B 1 103 ? 109.393 114.276 110.746 1.00 17.33  ? 103 PHE A CA   1 
ATOM   2790 C C    . PHE B 1 103 ? 109.203 114.742 112.186 1.00 17.07  ? 103 PHE A C    1 
ATOM   2791 O O    . PHE B 1 103 ? 110.043 115.464 112.733 1.00 23.34  ? 103 PHE A O    1 
ATOM   2792 C CB   . PHE B 1 103 ? 108.449 115.024 109.800 1.00 16.69  ? 103 PHE A CB   1 
ATOM   2793 C CG   . PHE B 1 103 ? 108.404 116.508 110.030 1.00 25.34  ? 103 PHE A CG   1 
ATOM   2794 C CD1  . PHE B 1 103 ? 109.469 117.315 109.667 1.00 21.65  ? 103 PHE A CD1  1 
ATOM   2795 C CD2  . PHE B 1 103 ? 107.293 117.098 110.616 1.00 24.43  ? 103 PHE A CD2  1 
ATOM   2796 C CE1  . PHE B 1 103 ? 109.426 118.681 109.878 1.00 22.09  ? 103 PHE A CE1  1 
ATOM   2797 C CE2  . PHE B 1 103 ? 107.246 118.460 110.829 1.00 22.37  ? 103 PHE A CE2  1 
ATOM   2798 C CZ   . PHE B 1 103 ? 108.315 119.253 110.460 1.00 21.13  ? 103 PHE A CZ   1 
ATOM   2799 N N    . VAL B 1 104 ? 108.095 114.344 112.813 1.00 19.40  ? 104 VAL A N    1 
ATOM   2800 C CA   . VAL B 1 104 ? 107.843 114.800 114.177 1.00 21.17  ? 104 VAL A CA   1 
ATOM   2801 C C    . VAL B 1 104 ? 108.874 114.208 115.133 1.00 19.19  ? 104 VAL A C    1 
ATOM   2802 O O    . VAL B 1 104 ? 109.266 114.860 116.113 1.00 20.03  ? 104 VAL A O    1 
ATOM   2803 C CB   . VAL B 1 104 ? 106.398 114.487 114.619 1.00 17.52  ? 104 VAL A CB   1 
ATOM   2804 C CG1  . VAL B 1 104 ? 105.402 115.211 113.725 1.00 14.26  ? 104 VAL A CG1  1 
ATOM   2805 C CG2  . VAL B 1 104 ? 106.129 112.996 114.635 1.00 12.86  ? 104 VAL A CG2  1 
ATOM   2806 N N    . GLY B 1 105 ? 109.328 112.976 114.878 1.00 28.03  ? 105 GLY A N    1 
ATOM   2807 C CA   . GLY B 1 105 ? 110.396 112.413 115.688 1.00 15.22  ? 105 GLY A CA   1 
ATOM   2808 C C    . GLY B 1 105 ? 111.687 113.202 115.588 1.00 17.24  ? 105 GLY A C    1 
ATOM   2809 O O    . GLY B 1 105 ? 112.368 113.426 116.592 1.00 22.03  ? 105 GLY A O    1 
ATOM   2810 N N    . THR B 1 106 ? 112.050 113.632 114.376 1.00 28.16  ? 106 THR A N    1 
ATOM   2811 C CA   . THR B 1 106 ? 113.232 114.475 114.224 1.00 24.36  ? 106 THR A CA   1 
ATOM   2812 C C    . THR B 1 106 ? 113.031 115.863 114.819 1.00 22.42  ? 106 THR A C    1 
ATOM   2813 O O    . THR B 1 106 ? 114.012 116.524 115.174 1.00 27.82  ? 106 THR A O    1 
ATOM   2814 C CB   . THR B 1 106 ? 113.629 114.609 112.753 1.00 23.83  ? 106 THR A CB   1 
ATOM   2815 O OG1  . THR B 1 106 ? 112.568 115.238 112.021 1.00 25.67  ? 106 THR A OG1  1 
ATOM   2816 C CG2  . THR B 1 106 ? 113.929 113.248 112.149 1.00 20.89  ? 106 THR A CG2  1 
ATOM   2817 N N    . VAL B 1 107 ? 111.783 116.316 114.935 1.00 23.83  ? 107 VAL A N    1 
ATOM   2818 C CA   . VAL B 1 107 ? 111.519 117.655 115.458 1.00 17.34  ? 107 VAL A CA   1 
ATOM   2819 C C    . VAL B 1 107 ? 111.619 117.670 116.978 1.00 17.80  ? 107 VAL A C    1 
ATOM   2820 O O    . VAL B 1 107 ? 112.315 118.509 117.562 1.00 22.55  ? 107 VAL A O    1 
ATOM   2821 C CB   . VAL B 1 107 ? 110.146 118.164 114.978 1.00 17.32  ? 107 VAL A CB   1 
ATOM   2822 C CG1  . VAL B 1 107 ? 109.685 119.332 115.831 1.00 17.46  ? 107 VAL A CG1  1 
ATOM   2823 C CG2  . VAL B 1 107 ? 110.221 118.576 113.518 1.00 15.72  ? 107 VAL A CG2  1 
ATOM   2824 N N    . VAL B 1 108 ? 110.928 116.741 117.646 1.00 26.31  ? 108 VAL A N    1 
ATOM   2825 C CA   . VAL B 1 108 ? 110.851 116.774 119.106 1.00 20.23  ? 108 VAL A CA   1 
ATOM   2826 C C    . VAL B 1 108 ? 112.211 116.507 119.744 1.00 25.00  ? 108 VAL A C    1 
ATOM   2827 O O    . VAL B 1 108 ? 112.476 116.954 120.865 1.00 31.02  ? 108 VAL A O    1 
ATOM   2828 C CB   . VAL B 1 108 ? 109.792 115.780 119.618 1.00 14.78  ? 108 VAL A CB   1 
ATOM   2829 C CG1  . VAL B 1 108 ? 108.408 116.170 119.123 1.00 17.72  ? 108 VAL A CG1  1 
ATOM   2830 C CG2  . VAL B 1 108 ? 110.142 114.354 119.212 1.00 15.97  ? 108 VAL A CG2  1 
ATOM   2831 N N    . SER B 1 109 ? 113.089 115.779 119.060 1.00 28.81  ? 109 SER A N    1 
ATOM   2832 C CA   . SER B 1 109 ? 114.425 115.492 119.566 1.00 18.16  ? 109 SER A CA   1 
ATOM   2833 C C    . SER B 1 109 ? 115.444 116.578 119.237 1.00 25.70  ? 109 SER A C    1 
ATOM   2834 O O    . SER B 1 109 ? 116.611 116.444 119.617 1.00 27.97  ? 109 SER A O    1 
ATOM   2835 C CB   . SER B 1 109 ? 114.916 114.151 119.013 1.00 18.92  ? 109 SER A CB   1 
ATOM   2836 O OG   . SER B 1 109 ? 114.888 114.150 117.598 1.00 18.20  ? 109 SER A OG   1 
ATOM   2837 N N    . THR B 1 110 ? 115.025 117.653 118.565 1.00 26.54  ? 110 THR A N    1 
ATOM   2838 C CA   . THR B 1 110 ? 115.903 118.755 118.146 1.00 21.32  ? 110 THR A CA   1 
ATOM   2839 C C    . THR B 1 110 ? 117.088 118.258 117.321 1.00 19.70  ? 110 THR A C    1 
ATOM   2840 O O    . THR B 1 110 ? 118.197 118.789 117.403 1.00 33.56  ? 110 THR A O    1 
ATOM   2841 C CB   . THR B 1 110 ? 116.392 119.595 119.338 1.00 27.34  ? 110 THR A CB   1 
ATOM   2842 O OG1  . THR B 1 110 ? 116.638 118.764 120.480 1.00 35.57  ? 110 THR A OG1  1 
ATOM   2843 C CG2  . THR B 1 110 ? 115.363 120.653 119.704 1.00 24.15  ? 110 THR A CG2  1 
ATOM   2844 N N    . ILE B 1 111 ? 116.846 117.239 116.500 1.00 8.99   ? 111 ILE A N    1 
ATOM   2845 C CA   . ILE B 1 111 ? 117.861 116.780 115.551 1.00 17.84  ? 111 ILE A CA   1 
ATOM   2846 C C    . ILE B 1 111 ? 117.836 117.648 114.302 1.00 30.87  ? 111 ILE A C    1 
ATOM   2847 O O    . ILE B 1 111 ? 118.857 118.212 113.892 1.00 38.94  ? 111 ILE A O    1 
ATOM   2848 C CB   . ILE B 1 111 ? 117.658 115.291 115.221 1.00 23.80  ? 111 ILE A CB   1 
ATOM   2849 C CG1  . ILE B 1 111 ? 117.937 114.434 116.459 1.00 26.55  ? 111 ILE A CG1  1 
ATOM   2850 C CG2  . ILE B 1 111 ? 118.556 114.870 114.069 1.00 12.47  ? 111 ILE A CG2  1 
ATOM   2851 C CD1  . ILE B 1 111 ? 117.790 112.950 116.226 1.00 22.21  ? 111 ILE A CD1  1 
ATOM   2852 N N    . GLY B 1 112 ? 116.670 117.753 113.673 1.00 18.48  ? 112 GLY A N    1 
ATOM   2853 C CA   . GLY B 1 112 ? 116.467 118.625 112.535 1.00 12.18  ? 112 GLY A CA   1 
ATOM   2854 C C    . GLY B 1 112 ? 117.208 118.321 111.252 1.00 19.34  ? 112 GLY A C    1 
ATOM   2855 O O    . GLY B 1 112 ? 117.813 119.226 110.668 1.00 31.85  ? 112 GLY A O    1 
ATOM   2856 N N    . PHE B 1 113 ? 117.199 117.051 110.823 1.00 24.99  ? 113 PHE A N    1 
ATOM   2857 C CA   . PHE B 1 113 ? 117.946 116.636 109.635 1.00 17.66  ? 113 PHE A CA   1 
ATOM   2858 C C    . PHE B 1 113 ? 117.749 117.608 108.475 1.00 25.90  ? 113 PHE A C    1 
ATOM   2859 O O    . PHE B 1 113 ? 118.697 117.908 107.740 1.00 36.00  ? 113 PHE A O    1 
ATOM   2860 C CB   . PHE B 1 113 ? 117.540 115.220 109.219 1.00 14.56  ? 113 PHE A CB   1 
ATOM   2861 C CG   . PHE B 1 113 ? 118.192 114.136 110.031 1.00 27.90  ? 113 PHE A CG   1 
ATOM   2862 C CD1  . PHE B 1 113 ? 119.538 114.210 110.350 1.00 34.31  ? 113 PHE A CD1  1 
ATOM   2863 C CD2  . PHE B 1 113 ? 117.467 113.037 110.458 1.00 28.00  ? 113 PHE A CD2  1 
ATOM   2864 C CE1  . PHE B 1 113 ? 120.146 113.211 111.087 1.00 30.92  ? 113 PHE A CE1  1 
ATOM   2865 C CE2  . PHE B 1 113 ? 118.067 112.036 111.196 1.00 24.94  ? 113 PHE A CE2  1 
ATOM   2866 C CZ   . PHE B 1 113 ? 119.409 112.125 111.513 1.00 25.26  ? 113 PHE A CZ   1 
ATOM   2867 N N    . GLY B 1 114 ? 116.522 118.093 108.284 1.00 19.41  ? 114 GLY A N    1 
ATOM   2868 C CA   . GLY B 1 114 ? 116.201 118.978 107.187 1.00 21.41  ? 114 GLY A CA   1 
ATOM   2869 C C    . GLY B 1 114 ? 115.735 118.306 105.914 1.00 27.86  ? 114 GLY A C    1 
ATOM   2870 O O    . GLY B 1 114 ? 115.442 119.009 104.939 1.00 33.54  ? 114 GLY A O    1 
ATOM   2871 N N    . MET B 1 115 ? 115.674 116.974 105.880 1.00 29.07  ? 115 MET A N    1 
ATOM   2872 C CA   . MET B 1 115 ? 115.160 116.282 104.705 1.00 24.99  ? 115 MET A CA   1 
ATOM   2873 C C    . MET B 1 115 ? 113.682 116.571 104.458 1.00 30.32  ? 115 MET A C    1 
ATOM   2874 O O    . MET B 1 115 ? 113.209 116.388 103.334 1.00 34.70  ? 115 MET A O    1 
ATOM   2875 C CB   . MET B 1 115 ? 115.392 114.776 104.836 1.00 22.90  ? 115 MET A CB   1 
ATOM   2876 C CG   . MET B 1 115 ? 114.335 114.038 105.640 1.00 31.45  ? 115 MET A CG   1 
ATOM   2877 S SD   . MET B 1 115 ? 114.620 114.117 107.415 1.00 47.03  ? 115 MET A SD   1 
ATOM   2878 C CE   . MET B 1 115 ? 113.317 113.043 108.015 1.00 19.15  ? 115 MET A CE   1 
ATOM   2879 N N    . THR B 1 116 ? 112.948 117.017 105.478 1.00 28.47  ? 116 THR A N    1 
ATOM   2880 C CA   . THR B 1 116 ? 111.523 117.308 105.351 1.00 23.39  ? 116 THR A CA   1 
ATOM   2881 C C    . THR B 1 116 ? 111.208 118.548 106.172 1.00 29.97  ? 116 THR A C    1 
ATOM   2882 O O    . THR B 1 116 ? 111.422 118.561 107.386 1.00 33.59  ? 116 THR A O    1 
ATOM   2883 C CB   . THR B 1 116 ? 110.674 116.121 105.819 1.00 19.22  ? 116 THR A CB   1 
ATOM   2884 O OG1  . THR B 1 116 ? 110.983 114.966 105.029 1.00 33.41  ? 116 THR A OG1  1 
ATOM   2885 C CG2  . THR B 1 116 ? 109.194 116.433 105.676 1.00 14.93  ? 116 THR A CG2  1 
ATOM   2886 N N    . THR B 1 117 ? 110.718 119.596 105.509 1.00 31.45  ? 117 THR A N    1 
ATOM   2887 C CA   . THR B 1 117 ? 110.423 120.864 106.160 1.00 24.92  ? 117 THR A CA   1 
ATOM   2888 C C    . THR B 1 117 ? 109.049 121.371 105.744 1.00 29.47  ? 117 THR A C    1 
ATOM   2889 O O    . THR B 1 117 ? 108.592 121.102 104.629 1.00 30.23  ? 117 THR A O    1 
ATOM   2890 C CB   . THR B 1 117 ? 111.478 121.926 105.814 1.00 25.60  ? 117 THR A CB   1 
ATOM   2891 O OG1  . THR B 1 117 ? 111.800 121.852 104.419 1.00 41.90  ? 117 THR A OG1  1 
ATOM   2892 C CG2  . THR B 1 117 ? 112.740 121.705 106.629 1.00 23.03  ? 117 THR A CG2  1 
ATOM   2893 N N    . PRO B 1 118 ? 108.365 122.103 106.627 1.00 30.29  ? 118 PRO A N    1 
ATOM   2894 C CA   . PRO B 1 118 ? 107.078 122.705 106.249 1.00 24.57  ? 118 PRO A CA   1 
ATOM   2895 C C    . PRO B 1 118 ? 107.241 123.736 105.145 1.00 26.51  ? 118 PRO A C    1 
ATOM   2896 O O    . PRO B 1 118 ? 108.229 124.471 105.092 1.00 33.26  ? 118 PRO A O    1 
ATOM   2897 C CB   . PRO B 1 118 ? 106.590 123.348 107.554 1.00 22.64  ? 118 PRO A CB   1 
ATOM   2898 C CG   . PRO B 1 118 ? 107.364 122.671 108.637 1.00 28.16  ? 118 PRO A CG   1 
ATOM   2899 C CD   . PRO B 1 118 ? 108.693 122.345 108.042 1.00 29.90  ? 118 PRO A CD   1 
ATOM   2900 N N    . ALA B 1 119 ? 106.246 123.799 104.257 1.00 23.73  ? 119 ALA A N    1 
ATOM   2901 C CA   . ALA B 1 119 ? 106.283 124.707 103.122 1.00 26.59  ? 119 ALA A CA   1 
ATOM   2902 C C    . ALA B 1 119 ? 105.067 125.616 103.001 1.00 31.74  ? 119 ALA A C    1 
ATOM   2903 O O    . ALA B 1 119 ? 105.040 126.458 102.097 1.00 38.41  ? 119 ALA A O    1 
ATOM   2904 C CB   . ALA B 1 119 ? 106.441 123.919 101.813 1.00 29.52  ? 119 ALA A CB   1 
ATOM   2905 N N    . THR B 1 120 ? 104.073 125.489 103.873 1.00 29.26  ? 120 THR A N    1 
ATOM   2906 C CA   . THR B 1 120 ? 102.855 126.280 103.779 1.00 27.41  ? 120 THR A CA   1 
ATOM   2907 C C    . THR B 1 120 ? 102.674 127.128 105.033 1.00 34.18  ? 120 THR A C    1 
ATOM   2908 O O    . THR B 1 120 ? 103.143 126.772 106.118 1.00 37.33  ? 120 THR A O    1 
ATOM   2909 C CB   . THR B 1 120 ? 101.615 125.393 103.584 1.00 28.31  ? 120 THR A CB   1 
ATOM   2910 O OG1  . THR B 1 120 ? 101.295 124.733 104.816 1.00 24.42  ? 120 THR A OG1  1 
ATOM   2911 C CG2  . THR B 1 120 ? 101.863 124.350 102.508 1.00 27.24  ? 120 THR A CG2  1 
ATOM   2912 N N    . VAL B 1 121 ? 101.996 128.262 104.862 1.00 35.54  ? 121 VAL A N    1 
ATOM   2913 C CA   . VAL B 1 121 ? 101.559 129.058 106.001 1.00 28.23  ? 121 VAL A CA   1 
ATOM   2914 C C    . VAL B 1 121 ? 100.453 128.307 106.730 1.00 37.25  ? 121 VAL A C    1 
ATOM   2915 O O    . VAL B 1 121 ? 99.446  127.910 106.130 1.00 40.76  ? 121 VAL A O    1 
ATOM   2916 C CB   . VAL B 1 121 ? 101.089 130.447 105.546 1.00 30.47  ? 121 VAL A CB   1 
ATOM   2917 C CG1  . VAL B 1 121 ? 100.295 131.130 106.650 1.00 29.56  ? 121 VAL A CG1  1 
ATOM   2918 C CG2  . VAL B 1 121 ? 102.271 131.300 105.133 1.00 35.84  ? 121 VAL A CG2  1 
ATOM   2919 N N    . GLY B 1 122 ? 100.637 128.110 108.030 1.00 27.83  ? 122 GLY A N    1 
ATOM   2920 C CA   . GLY B 1 122 ? 99.748  127.268 108.806 1.00 23.02  ? 122 GLY A CA   1 
ATOM   2921 C C    . GLY B 1 122 ? 100.477 126.059 109.349 1.00 29.87  ? 122 GLY A C    1 
ATOM   2922 O O    . GLY B 1 122 ? 100.288 125.678 110.508 1.00 40.21  ? 122 GLY A O    1 
ATOM   2923 N N    . GLY B 1 123 ? 101.324 125.450 108.519 1.00 22.51  ? 123 GLY A N    1 
ATOM   2924 C CA   . GLY B 1 123 ? 102.238 124.435 109.000 1.00 21.40  ? 123 GLY A CA   1 
ATOM   2925 C C    . GLY B 1 123 ? 103.463 124.967 109.703 1.00 24.80  ? 123 GLY A C    1 
ATOM   2926 O O    . GLY B 1 123 ? 104.079 124.237 110.486 1.00 30.26  ? 123 GLY A O    1 
ATOM   2927 N N    . LYS B 1 124 ? 103.747 126.263 109.560 1.00 27.57  ? 124 LYS A N    1 
ATOM   2928 C CA   . LYS B 1 124 ? 104.864 126.870 110.275 1.00 23.86  ? 124 LYS A CA   1 
ATOM   2929 C C    . LYS B 1 124 ? 104.432 127.448 111.610 1.00 28.65  ? 124 LYS A C    1 
ATOM   2930 O O    . LYS B 1 124 ? 105.182 127.355 112.587 1.00 30.37  ? 124 LYS A O    1 
ATOM   2931 C CB   . LYS B 1 124 ? 105.501 127.968 109.414 1.00 24.25  ? 124 LYS A CB   1 
ATOM   2932 C CG   . LYS B 1 124 ? 106.097 127.458 108.116 1.00 20.79  ? 124 LYS A CG   1 
ATOM   2933 C CD   . LYS B 1 124 ? 106.783 128.567 107.345 1.00 19.98  ? 124 LYS A CD   1 
ATOM   2934 C CE   . LYS B 1 124 ? 107.457 128.023 106.099 1.00 21.95  ? 124 LYS A CE   1 
ATOM   2935 N NZ   . LYS B 1 124 ? 108.095 129.092 105.288 1.00 25.92  ? 124 LYS A NZ   1 
ATOM   2936 N N    . ILE B 1 125 ? 103.207 127.964 111.700 1.00 25.61  ? 125 ILE A N    1 
ATOM   2937 C CA   . ILE B 1 125 ? 102.689 128.361 113.002 1.00 25.74  ? 125 ILE A CA   1 
ATOM   2938 C C    . ILE B 1 125 ? 102.504 127.118 113.859 1.00 29.88  ? 125 ILE A C    1 
ATOM   2939 O O    . ILE B 1 125 ? 102.883 127.084 115.041 1.00 32.99  ? 125 ILE A O    1 
ATOM   2940 C CB   . ILE B 1 125 ? 101.372 129.144 112.843 1.00 20.37  ? 125 ILE A CB   1 
ATOM   2941 C CG1  . ILE B 1 125 ? 101.485 130.155 111.703 1.00 19.41  ? 125 ILE A CG1  1 
ATOM   2942 C CG2  . ILE B 1 125 ? 101.005 129.844 114.137 1.00 28.78  ? 125 ILE A CG2  1 
ATOM   2943 C CD1  . ILE B 1 125 ? 100.182 130.848 111.382 1.00 22.09  ? 125 ILE A CD1  1 
ATOM   2944 N N    . PHE B 1 126 ? 101.884 126.085 113.280 1.00 25.21  ? 126 PHE A N    1 
ATOM   2945 C CA   . PHE B 1 126 ? 101.729 124.826 113.992 1.00 21.09  ? 126 PHE A CA   1 
ATOM   2946 C C    . PHE B 1 126 ? 103.082 124.213 114.318 1.00 19.21  ? 126 PHE A C    1 
ATOM   2947 O O    . PHE B 1 126 ? 103.238 123.603 115.377 1.00 28.26  ? 126 PHE A O    1 
ATOM   2948 C CB   . PHE B 1 126 ? 100.883 123.855 113.164 1.00 21.01  ? 126 PHE A CB   1 
ATOM   2949 C CG   . PHE B 1 126 ? 100.535 122.588 113.893 1.00 27.82  ? 126 PHE A CG   1 
ATOM   2950 C CD1  . PHE B 1 126 ? 99.668  122.610 114.971 1.00 25.73  ? 126 PHE A CD1  1 
ATOM   2951 C CD2  . PHE B 1 126 ? 101.072 121.378 113.495 1.00 26.14  ? 126 PHE A CD2  1 
ATOM   2952 C CE1  . PHE B 1 126 ? 99.349  121.446 115.641 1.00 22.60  ? 126 PHE A CE1  1 
ATOM   2953 C CE2  . PHE B 1 126 ? 100.757 120.213 114.161 1.00 19.92  ? 126 PHE A CE2  1 
ATOM   2954 C CZ   . PHE B 1 126 ? 99.893  120.245 115.236 1.00 25.75  ? 126 PHE A CZ   1 
ATOM   2955 N N    . LEU B 1 127 ? 104.079 124.376 113.435 1.00 15.57  ? 127 LEU A N    1 
ATOM   2956 C CA   . LEU B 1 127 ? 105.424 123.904 113.750 1.00 22.29  ? 127 LEU A CA   1 
ATOM   2957 C C    . LEU B 1 127 ? 105.976 124.605 114.987 1.00 24.92  ? 127 LEU A C    1 
ATOM   2958 O O    . LEU B 1 127 ? 106.540 123.962 115.880 1.00 28.28  ? 127 LEU A O    1 
ATOM   2959 C CB   . LEU B 1 127 ? 106.342 124.117 112.547 1.00 23.88  ? 127 LEU A CB   1 
ATOM   2960 C CG   . LEU B 1 127 ? 107.752 123.510 112.554 1.00 22.78  ? 127 LEU A CG   1 
ATOM   2961 C CD1  . LEU B 1 127 ? 108.781 124.471 113.134 1.00 18.56  ? 127 LEU A CD1  1 
ATOM   2962 C CD2  . LEU B 1 127 ? 107.779 122.183 113.293 1.00 23.13  ? 127 LEU A CD2  1 
ATOM   2963 N N    . ILE B 1 128 ? 105.787 125.925 115.067 1.00 25.51  ? 128 ILE A N    1 
ATOM   2964 C CA   . ILE B 1 128 ? 106.308 126.693 116.194 1.00 25.41  ? 128 ILE A CA   1 
ATOM   2965 C C    . ILE B 1 128 ? 105.654 126.237 117.493 1.00 27.40  ? 128 ILE A C    1 
ATOM   2966 O O    . ILE B 1 128 ? 106.336 125.939 118.482 1.00 28.76  ? 128 ILE A O    1 
ATOM   2967 C CB   . ILE B 1 128 ? 106.106 128.201 115.956 1.00 25.20  ? 128 ILE A CB   1 
ATOM   2968 C CG1  . ILE B 1 128 ? 107.017 128.688 114.829 1.00 23.60  ? 128 ILE A CG1  1 
ATOM   2969 C CG2  . ILE B 1 128 ? 106.366 128.987 117.232 1.00 21.67  ? 128 ILE A CG2  1 
ATOM   2970 C CD1  . ILE B 1 128 ? 106.844 130.149 114.491 1.00 18.26  ? 128 ILE A CD1  1 
ATOM   2971 N N    . PHE B 1 129 ? 104.319 126.165 117.501 1.00 26.94  ? 129 PHE A N    1 
ATOM   2972 C CA   . PHE B 1 129 ? 103.619 125.769 118.722 1.00 22.80  ? 129 PHE A CA   1 
ATOM   2973 C C    . PHE B 1 129 ? 103.930 124.321 119.105 1.00 25.86  ? 129 PHE A C    1 
ATOM   2974 O O    . PHE B 1 129 ? 104.135 124.016 120.290 1.00 28.41  ? 129 PHE A O    1 
ATOM   2975 C CB   . PHE B 1 129 ? 102.114 125.976 118.561 1.00 18.88  ? 129 PHE A CB   1 
ATOM   2976 C CG   . PHE B 1 129 ? 101.682 127.412 118.685 1.00 25.01  ? 129 PHE A CG   1 
ATOM   2977 C CD1  . PHE B 1 129 ? 101.689 128.250 117.584 1.00 27.66  ? 129 PHE A CD1  1 
ATOM   2978 C CD2  . PHE B 1 129 ? 101.278 127.923 119.907 1.00 29.39  ? 129 PHE A CD2  1 
ATOM   2979 C CE1  . PHE B 1 129 ? 101.296 129.569 117.699 1.00 31.00  ? 129 PHE A CE1  1 
ATOM   2980 C CE2  . PHE B 1 129 ? 100.882 129.239 120.026 1.00 32.84  ? 129 PHE A CE2  1 
ATOM   2981 C CZ   . PHE B 1 129 ? 100.893 130.064 118.921 1.00 33.24  ? 129 PHE A CZ   1 
ATOM   2982 N N    . TYR B 1 130 ? 103.983 123.422 118.120 1.00 21.77  ? 130 TYR A N    1 
ATOM   2983 C CA   . TYR B 1 130 ? 104.285 122.021 118.382 1.00 19.43  ? 130 TYR A CA   1 
ATOM   2984 C C    . TYR B 1 130 ? 105.660 121.869 119.018 1.00 26.09  ? 130 TYR A C    1 
ATOM   2985 O O    . TYR B 1 130 ? 105.817 121.158 120.019 1.00 26.95  ? 130 TYR A O    1 
ATOM   2986 C CB   . TYR B 1 130 ? 104.196 121.226 117.077 1.00 9.99   ? 130 TYR A CB   1 
ATOM   2987 C CG   . TYR B 1 130 ? 104.150 119.725 117.248 1.00 21.26  ? 130 TYR A CG   1 
ATOM   2988 C CD1  . TYR B 1 130 ? 102.958 119.074 117.531 1.00 21.84  ? 130 TYR A CD1  1 
ATOM   2989 C CD2  . TYR B 1 130 ? 105.300 118.959 117.117 1.00 19.42  ? 130 TYR A CD2  1 
ATOM   2990 C CE1  . TYR B 1 130 ? 102.910 117.706 117.682 1.00 15.51  ? 130 TYR A CE1  1 
ATOM   2991 C CE2  . TYR B 1 130 ? 105.264 117.591 117.267 1.00 21.08  ? 130 TYR A CE2  1 
ATOM   2992 C CZ   . TYR B 1 130 ? 104.067 116.968 117.549 1.00 19.29  ? 130 TYR A CZ   1 
ATOM   2993 O OH   . TYR B 1 130 ? 104.029 115.603 117.699 1.00 29.98  ? 130 TYR A OH   1 
ATOM   2994 N N    . GLY B 1 131 ? 106.673 122.534 118.458 1.00 21.42  ? 131 GLY A N    1 
ATOM   2995 C CA   . GLY B 1 131 ? 108.001 122.454 119.047 1.00 18.87  ? 131 GLY A CA   1 
ATOM   2996 C C    . GLY B 1 131 ? 108.058 123.064 120.432 1.00 21.64  ? 131 GLY A C    1 
ATOM   2997 O O    . GLY B 1 131 ? 108.660 122.492 121.352 1.00 27.36  ? 131 GLY A O    1 
ATOM   2998 N N    . LEU B 1 132 ? 107.392 124.212 120.611 1.00 22.76  ? 132 LEU A N    1 
ATOM   2999 C CA   . LEU B 1 132 ? 107.383 124.901 121.896 1.00 23.20  ? 132 LEU A CA   1 
ATOM   3000 C C    . LEU B 1 132 ? 106.777 124.034 122.990 1.00 22.79  ? 132 LEU A C    1 
ATOM   3001 O O    . LEU B 1 132 ? 107.194 124.108 124.152 1.00 28.48  ? 132 LEU A O    1 
ATOM   3002 C CB   . LEU B 1 132 ? 106.615 126.217 121.768 1.00 26.60  ? 132 LEU A CB   1 
ATOM   3003 C CG   . LEU B 1 132 ? 106.725 127.221 122.914 1.00 28.79  ? 132 LEU A CG   1 
ATOM   3004 C CD1  . LEU B 1 132 ? 108.112 127.836 122.962 1.00 28.90  ? 132 LEU A CD1  1 
ATOM   3005 C CD2  . LEU B 1 132 ? 105.664 128.300 122.774 1.00 27.69  ? 132 LEU A CD2  1 
ATOM   3006 N N    . VAL B 1 133 ? 105.776 123.222 122.648 1.00 30.13  ? 133 VAL A N    1 
ATOM   3007 C CA   . VAL B 1 133 ? 105.185 122.336 123.646 1.00 28.01  ? 133 VAL A CA   1 
ATOM   3008 C C    . VAL B 1 133 ? 105.912 120.996 123.759 1.00 26.36  ? 133 VAL A C    1 
ATOM   3009 O O    . VAL B 1 133 ? 105.850 120.356 124.819 1.00 23.84  ? 133 VAL A O    1 
ATOM   3010 C CB   . VAL B 1 133 ? 103.690 122.105 123.354 1.00 27.28  ? 133 VAL A CB   1 
ATOM   3011 C CG1  . VAL B 1 133 ? 103.019 121.349 124.494 1.00 18.55  ? 133 VAL A CG1  1 
ATOM   3012 C CG2  . VAL B 1 133 ? 102.981 123.429 123.137 1.00 23.85  ? 133 VAL A CG2  1 
ATOM   3013 N N    . GLY B 1 134 ? 106.647 120.580 122.729 1.00 26.12  ? 134 GLY A N    1 
ATOM   3014 C CA   . GLY B 1 134 ? 107.188 119.234 122.705 1.00 16.71  ? 134 GLY A CA   1 
ATOM   3015 C C    . GLY B 1 134 ? 108.645 119.030 123.072 1.00 22.47  ? 134 GLY A C    1 
ATOM   3016 O O    . GLY B 1 134 ? 109.001 117.963 123.579 1.00 26.89  ? 134 GLY A O    1 
ATOM   3017 N N    . CYS B 1 135 ? 109.505 120.021 122.824 1.00 22.14  ? 135 CYS A N    1 
ATOM   3018 C CA   . CYS B 1 135 ? 110.916 119.862 123.186 1.00 17.69  ? 135 CYS A CA   1 
ATOM   3019 C C    . CYS B 1 135 ? 111.164 119.729 124.689 1.00 25.67  ? 135 CYS A C    1 
ATOM   3020 O O    . CYS B 1 135 ? 111.939 118.839 125.088 1.00 34.64  ? 135 CYS A O    1 
ATOM   3021 C CB   . CYS B 1 135 ? 111.726 121.018 122.585 1.00 27.87  ? 135 CYS A CB   1 
ATOM   3022 S SG   . CYS B 1 135 ? 111.698 121.087 120.778 1.00 32.82  ? 135 CYS A SG   1 
ATOM   3023 N N    . PRO B 1 136 ? 110.565 120.546 125.566 1.00 23.64  ? 136 PRO A N    1 
ATOM   3024 C CA   . PRO B 1 136 ? 110.771 120.333 127.011 1.00 15.58  ? 136 PRO A CA   1 
ATOM   3025 C C    . PRO B 1 136 ? 110.350 118.959 127.506 1.00 21.62  ? 136 PRO A C    1 
ATOM   3026 O O    . PRO B 1 136 ? 110.985 118.429 128.429 1.00 31.89  ? 136 PRO A O    1 
ATOM   3027 C CB   . PRO B 1 136 ? 109.926 121.446 127.647 1.00 22.63  ? 136 PRO A CB   1 
ATOM   3028 C CG   . PRO B 1 136 ? 109.862 122.502 126.610 1.00 20.36  ? 136 PRO A CG   1 
ATOM   3029 C CD   . PRO B 1 136 ? 109.795 121.778 125.307 1.00 17.05  ? 136 PRO A CD   1 
ATOM   3030 N N    . SER B 1 137 ? 109.308 118.360 126.928 1.00 13.63  ? 137 SER A N    1 
ATOM   3031 C CA   . SER B 1 137 ? 108.910 117.018 127.345 1.00 12.50  ? 137 SER A CA   1 
ATOM   3032 C C    . SER B 1 137 ? 110.010 116.000 127.057 1.00 20.16  ? 137 SER A C    1 
ATOM   3033 O O    . SER B 1 137 ? 110.292 115.129 127.885 1.00 37.09  ? 137 SER A O    1 
ATOM   3034 C CB   . SER B 1 137 ? 107.607 116.622 126.652 1.00 22.10  ? 137 SER A CB   1 
ATOM   3035 O OG   . SER B 1 137 ? 106.624 117.627 126.805 1.00 31.04  ? 137 SER A OG   1 
ATOM   3036 N N    . THR B 1 138 ? 110.647 116.105 125.890 1.00 17.93  ? 138 THR A N    1 
ATOM   3037 C CA   . THR B 1 138 ? 111.733 115.187 125.556 1.00 22.16  ? 138 THR A CA   1 
ATOM   3038 C C    . THR B 1 138 ? 112.953 115.426 126.437 1.00 22.66  ? 138 THR A C    1 
ATOM   3039 O O    . THR B 1 138 ? 113.637 114.472 126.837 1.00 30.08  ? 138 THR A O    1 
ATOM   3040 C CB   . THR B 1 138 ? 112.093 115.327 124.077 1.00 23.23  ? 138 THR A CB   1 
ATOM   3041 O OG1  . THR B 1 138 ? 110.890 115.409 123.302 1.00 24.43  ? 138 THR A OG1  1 
ATOM   3042 C CG2  . THR B 1 138 ? 112.911 114.136 123.610 1.00 22.69  ? 138 THR A CG2  1 
ATOM   3043 N N    . ILE B 1 139 ? 113.237 116.691 126.765 1.00 17.19  ? 139 ILE A N    1 
ATOM   3044 C CA   . ILE B 1 139 ? 114.335 116.976 127.691 1.00 23.47  ? 139 ILE A CA   1 
ATOM   3045 C C    . ILE B 1 139 ? 114.066 116.336 129.052 1.00 28.31  ? 139 ILE A C    1 
ATOM   3046 O O    . ILE B 1 139 ? 114.959 115.720 129.660 1.00 33.10  ? 139 ILE A O    1 
ATOM   3047 C CB   . ILE B 1 139 ? 114.551 118.496 127.804 1.00 24.78  ? 139 ILE A CB   1 
ATOM   3048 C CG1  . ILE B 1 139 ? 115.011 119.067 126.463 1.00 23.36  ? 139 ILE A CG1  1 
ATOM   3049 C CG2  . ILE B 1 139 ? 115.568 118.815 128.886 1.00 25.89  ? 139 ILE A CG2  1 
ATOM   3050 C CD1  . ILE B 1 139 ? 115.189 120.567 126.468 1.00 22.00  ? 139 ILE A CD1  1 
ATOM   3051 N N    . LEU B 1 140 ? 112.832 116.464 129.544 1.00 17.90  ? 140 LEU A N    1 
ATOM   3052 C CA   . LEU B 1 140 ? 112.467 115.853 130.818 1.00 18.66  ? 140 LEU A CA   1 
ATOM   3053 C C    . LEU B 1 140 ? 112.572 114.333 130.753 1.00 27.94  ? 140 LEU A C    1 
ATOM   3054 O O    . LEU B 1 140 ? 113.007 113.689 131.716 1.00 35.35  ? 140 LEU A O    1 
ATOM   3055 C CB   . LEU B 1 140 ? 111.052 116.276 131.211 1.00 14.80  ? 140 LEU A CB   1 
ATOM   3056 C CG   . LEU B 1 140 ? 110.518 115.750 132.543 1.00 17.74  ? 140 LEU A CG   1 
ATOM   3057 C CD1  . LEU B 1 140 ? 111.311 116.310 133.712 1.00 17.54  ? 140 LEU A CD1  1 
ATOM   3058 C CD2  . LEU B 1 140 ? 109.041 116.068 132.689 1.00 19.72  ? 140 LEU A CD2  1 
ATOM   3059 N N    . PHE B 1 141 ? 112.173 113.744 129.622 1.00 25.67  ? 141 PHE A N    1 
ATOM   3060 C CA   . PHE B 1 141 ? 112.295 112.301 129.452 1.00 21.35  ? 141 PHE A CA   1 
ATOM   3061 C C    . PHE B 1 141 ? 113.750 111.859 129.539 1.00 27.79  ? 141 PHE A C    1 
ATOM   3062 O O    . PHE B 1 141 ? 114.065 110.852 130.179 1.00 29.57  ? 141 PHE A O    1 
ATOM   3063 C CB   . PHE B 1 141 ? 111.678 111.879 128.115 1.00 20.19  ? 141 PHE A CB   1 
ATOM   3064 C CG   . PHE B 1 141 ? 111.658 110.392 127.890 1.00 30.63  ? 141 PHE A CG   1 
ATOM   3065 C CD1  . PHE B 1 141 ? 110.687 109.604 128.485 1.00 25.06  ? 141 PHE A CD1  1 
ATOM   3066 C CD2  . PHE B 1 141 ? 112.601 109.783 127.080 1.00 30.49  ? 141 PHE A CD2  1 
ATOM   3067 C CE1  . PHE B 1 141 ? 110.660 108.239 128.282 1.00 20.35  ? 141 PHE A CE1  1 
ATOM   3068 C CE2  . PHE B 1 141 ? 112.579 108.417 126.873 1.00 26.73  ? 141 PHE A CE2  1 
ATOM   3069 C CZ   . PHE B 1 141 ? 111.608 107.645 127.476 1.00 24.20  ? 141 PHE A CZ   1 
ATOM   3070 N N    . PHE B 1 142 ? 114.654 112.609 128.900 1.00 28.66  ? 142 PHE A N    1 
ATOM   3071 C CA   . PHE B 1 142 ? 116.073 112.268 128.970 1.00 24.18  ? 142 PHE A CA   1 
ATOM   3072 C C    . PHE B 1 142 ? 116.605 112.374 130.397 1.00 31.80  ? 142 PHE A C    1 
ATOM   3073 O O    . PHE B 1 142 ? 117.379 111.516 130.847 1.00 37.73  ? 142 PHE A O    1 
ATOM   3074 C CB   . PHE B 1 142 ? 116.879 113.167 128.030 1.00 27.05  ? 142 PHE A CB   1 
ATOM   3075 C CG   . PHE B 1 142 ? 116.592 112.939 126.575 1.00 26.49  ? 142 PHE A CG   1 
ATOM   3076 C CD1  . PHE B 1 142 ? 116.024 111.753 126.141 1.00 29.14  ? 142 PHE A CD1  1 
ATOM   3077 C CD2  . PHE B 1 142 ? 116.889 113.915 125.639 1.00 27.49  ? 142 PHE A CD2  1 
ATOM   3078 C CE1  . PHE B 1 142 ? 115.761 111.543 124.802 1.00 30.27  ? 142 PHE A CE1  1 
ATOM   3079 C CE2  . PHE B 1 142 ? 116.628 113.710 124.299 1.00 27.87  ? 142 PHE A CE2  1 
ATOM   3080 C CZ   . PHE B 1 142 ? 116.063 112.523 123.881 1.00 28.72  ? 142 PHE A CZ   1 
ATOM   3081 N N    . ASN B 1 143 ? 116.201 113.418 131.127 1.00 32.31  ? 143 ASN A N    1 
ATOM   3082 C CA   . ASN B 1 143 ? 116.650 113.552 132.513 1.00 24.82  ? 143 ASN A CA   1 
ATOM   3083 C C    . ASN B 1 143 ? 116.154 112.395 133.377 1.00 30.13  ? 143 ASN A C    1 
ATOM   3084 O O    . ASN B 1 143 ? 116.914 111.842 134.192 1.00 42.48  ? 143 ASN A O    1 
ATOM   3085 C CB   . ASN B 1 143 ? 116.180 114.888 133.089 1.00 25.33  ? 143 ASN A CB   1 
ATOM   3086 C CG   . ASN B 1 143 ? 116.841 116.076 132.421 1.00 37.52  ? 143 ASN A CG   1 
ATOM   3087 O OD1  . ASN B 1 143 ? 117.924 115.958 131.849 1.00 43.89  ? 143 ASN A OD1  1 
ATOM   3088 N ND2  . ASN B 1 143 ? 116.190 117.230 132.489 1.00 36.09  ? 143 ASN A ND2  1 
ATOM   3089 N N    . LEU B 1 144 ? 114.885 112.015 133.219 1.00 26.28  ? 144 LEU A N    1 
ATOM   3090 C CA   . LEU B 1 144 ? 114.345 110.892 133.980 1.00 26.41  ? 144 LEU A CA   1 
ATOM   3091 C C    . LEU B 1 144 ? 115.054 109.590 133.624 1.00 30.50  ? 144 LEU A C    1 
ATOM   3092 O O    . LEU B 1 144 ? 115.311 108.752 134.499 1.00 38.61  ? 144 LEU A O    1 
ATOM   3093 C CB   . LEU B 1 144 ? 112.840 110.767 133.750 1.00 29.73  ? 144 LEU A CB   1 
ATOM   3094 C CG   . LEU B 1 144 ? 111.975 111.955 134.177 1.00 21.73  ? 144 LEU A CG   1 
ATOM   3095 C CD1  . LEU B 1 144 ? 110.501 111.638 133.981 1.00 21.96  ? 144 LEU A CD1  1 
ATOM   3096 C CD2  . LEU B 1 144 ? 112.255 112.336 135.622 1.00 29.05  ? 144 LEU A CD2  1 
ATOM   3097 N N    . PHE B 1 145 ? 115.372 109.401 132.340 1.00 31.59  ? 145 PHE A N    1 
ATOM   3098 C CA   . PHE B 1 145 ? 116.126 108.218 131.937 1.00 32.20  ? 145 PHE A CA   1 
ATOM   3099 C C    . PHE B 1 145 ? 117.483 108.180 132.623 1.00 32.40  ? 145 PHE A C    1 
ATOM   3100 O O    . PHE B 1 145 ? 117.924 107.119 133.079 1.00 39.20  ? 145 PHE A O    1 
ATOM   3101 C CB   . PHE B 1 145 ? 116.304 108.183 130.419 1.00 32.45  ? 145 PHE A CB   1 
ATOM   3102 C CG   . PHE B 1 145 ? 117.448 107.319 129.969 1.00 38.08  ? 145 PHE A CG   1 
ATOM   3103 C CD1  . PHE B 1 145 ? 117.307 105.943 129.910 1.00 36.94  ? 145 PHE A CD1  1 
ATOM   3104 C CD2  . PHE B 1 145 ? 118.668 107.876 129.622 1.00 34.76  ? 145 PHE A CD2  1 
ATOM   3105 C CE1  . PHE B 1 145 ? 118.357 105.141 129.504 1.00 35.15  ? 145 PHE A CE1  1 
ATOM   3106 C CE2  . PHE B 1 145 ? 119.724 107.077 129.221 1.00 32.83  ? 145 PHE A CE2  1 
ATOM   3107 C CZ   . PHE B 1 145 ? 119.565 105.708 129.160 1.00 34.73  ? 145 PHE A CZ   1 
ATOM   3108 N N    . LEU B 1 146 ? 118.175 109.321 132.676 1.00 30.70  ? 146 LEU A N    1 
ATOM   3109 C CA   . LEU B 1 146 ? 119.483 109.348 133.327 1.00 32.47  ? 146 LEU A CA   1 
ATOM   3110 C C    . LEU B 1 146 ? 119.372 109.010 134.809 1.00 36.87  ? 146 LEU A C    1 
ATOM   3111 O O    . LEU B 1 146 ? 120.199 108.256 135.347 1.00 44.41  ? 146 LEU A O    1 
ATOM   3112 C CB   . LEU B 1 146 ? 120.137 110.716 133.142 1.00 34.39  ? 146 LEU A CB   1 
ATOM   3113 C CG   . LEU B 1 146 ? 121.497 110.897 133.822 1.00 38.26  ? 146 LEU A CG   1 
ATOM   3114 C CD1  . LEU B 1 146 ? 122.489 109.840 133.374 1.00 33.54  ? 146 LEU A CD1  1 
ATOM   3115 C CD2  . LEU B 1 146 ? 122.046 112.290 133.559 1.00 36.44  ? 146 LEU A CD2  1 
ATOM   3116 N N    . GLU B 1 147 ? 118.359 109.555 135.487 1.00 40.11  ? 147 GLU A N    1 
ATOM   3117 C CA   . GLU B 1 147 ? 118.177 109.229 136.901 1.00 36.39  ? 147 GLU A CA   1 
ATOM   3118 C C    . GLU B 1 147 ? 117.916 107.737 137.100 1.00 40.23  ? 147 GLU A C    1 
ATOM   3119 O O    . GLU B 1 147 ? 118.503 107.105 137.994 1.00 47.25  ? 147 GLU A O    1 
ATOM   3120 C CB   . GLU B 1 147 ? 117.037 110.061 137.488 1.00 41.15  ? 147 GLU A CB   1 
ATOM   3121 C CG   . GLU B 1 147 ? 116.507 109.534 138.809 1.00 48.75  ? 147 GLU A CG   1 
ATOM   3122 C CD   . GLU B 1 147 ? 115.272 110.273 139.280 1.00 59.35  ? 147 GLU A CD   1 
ATOM   3123 O OE1  . GLU B 1 147 ? 114.970 111.349 138.722 1.00 59.80  ? 147 GLU A OE1  1 
ATOM   3124 O OE2  . GLU B 1 147 ? 114.603 109.778 140.211 1.00 55.40  ? 147 GLU A OE2  1 
ATOM   3125 N N    . ARG B 1 148 ? 117.048 107.153 136.268 1.00 42.79  ? 148 ARG A N    1 
ATOM   3126 C CA   . ARG B 1 148 ? 116.758 105.726 136.384 1.00 40.88  ? 148 ARG A CA   1 
ATOM   3127 C C    . ARG B 1 148 ? 118.000 104.885 136.117 1.00 43.14  ? 148 ARG A C    1 
ATOM   3128 O O    . ARG B 1 148 ? 118.229 103.868 136.786 1.00 40.58  ? 148 ARG A O    1 
ATOM   3129 C CB   . ARG B 1 148 ? 115.627 105.336 135.430 1.00 34.14  ? 148 ARG A CB   1 
ATOM   3130 C CG   . ARG B 1 148 ? 114.263 105.885 135.820 1.00 29.23  ? 148 ARG A CG   1 
ATOM   3131 C CD   . ARG B 1 148 ? 113.645 105.082 136.956 1.00 33.03  ? 148 ARG A CD   1 
ATOM   3132 N NE   . ARG B 1 148 ? 114.088 105.561 138.260 1.00 41.95  ? 148 ARG A NE   1 
ATOM   3133 C CZ   . ARG B 1 148 ? 113.842 104.943 139.409 1.00 36.84  ? 148 ARG A CZ   1 
ATOM   3134 N NH1  . ARG B 1 148 ? 113.173 103.803 139.452 1.00 38.14  ? 148 ARG A NH1  1 
ATOM   3135 N NH2  . ARG B 1 148 ? 114.288 105.480 140.539 1.00 36.22  ? 148 ARG A NH2  1 
ATOM   3136 N N    . LEU B 1 149 ? 118.803 105.282 135.126 1.00 47.66  ? 149 LEU A N    1 
ATOM   3137 C CA   . LEU B 1 149 ? 120.027 104.547 134.823 1.00 41.96  ? 149 LEU A CA   1 
ATOM   3138 C C    . LEU B 1 149 ? 121.003 104.588 135.991 1.00 38.91  ? 149 LEU A C    1 
ATOM   3139 O O    . LEU B 1 149 ? 121.614 103.569 136.333 1.00 42.13  ? 149 LEU A O    1 
ATOM   3140 C CB   . LEU B 1 149 ? 120.677 105.114 133.561 1.00 38.73  ? 149 LEU A CB   1 
ATOM   3141 C CG   . LEU B 1 149 ? 122.017 104.493 133.165 1.00 37.58  ? 149 LEU A CG   1 
ATOM   3142 C CD1  . LEU B 1 149 ? 121.835 103.039 132.759 1.00 40.78  ? 149 LEU A CD1  1 
ATOM   3143 C CD2  . LEU B 1 149 ? 122.663 105.287 132.045 1.00 38.92  ? 149 LEU A CD2  1 
ATOM   3144 N N    . ILE B 1 150 ? 121.167 105.758 136.614 1.00 38.77  ? 150 ILE A N    1 
ATOM   3145 C CA   . ILE B 1 150 ? 122.057 105.843 137.771 1.00 38.87  ? 150 ILE A CA   1 
ATOM   3146 C C    . ILE B 1 150 ? 121.554 104.949 138.898 1.00 43.38  ? 150 ILE A C    1 
ATOM   3147 O O    . ILE B 1 150 ? 122.337 104.232 139.542 1.00 47.46  ? 150 ILE A O    1 
ATOM   3148 C CB   . ILE B 1 150 ? 122.208 107.306 138.228 1.00 39.71  ? 150 ILE A CB   1 
ATOM   3149 C CG1  . ILE B 1 150 ? 122.944 108.126 137.169 1.00 38.95  ? 150 ILE A CG1  1 
ATOM   3150 C CG2  . ILE B 1 150 ? 122.944 107.380 139.557 1.00 39.89  ? 150 ILE A CG2  1 
ATOM   3151 C CD1  . ILE B 1 150 ? 123.100 109.584 137.532 1.00 40.21  ? 150 ILE A CD1  1 
ATOM   3152 N N    . THR B 1 151 ? 120.241 104.964 139.144 1.00 50.03  ? 151 THR A N    1 
ATOM   3153 C CA   . THR B 1 151 ? 119.685 104.124 140.203 1.00 48.87  ? 151 THR A CA   1 
ATOM   3154 C C    . THR B 1 151 ? 119.919 102.642 139.926 1.00 50.14  ? 151 THR A C    1 
ATOM   3155 O O    . THR B 1 151 ? 120.321 101.889 140.823 1.00 53.34  ? 151 THR A O    1 
ATOM   3156 C CB   . THR B 1 151 ? 118.192 104.408 140.371 1.00 48.89  ? 151 THR A CB   1 
ATOM   3157 O OG1  . THR B 1 151 ? 118.007 105.763 140.795 1.00 54.33  ? 151 THR A OG1  1 
ATOM   3158 C CG2  . THR B 1 151 ? 117.582 103.476 141.401 1.00 45.80  ? 151 THR A CG2  1 
ATOM   3159 N N    . ILE B 1 152 ? 119.678 102.202 138.685 1.00 52.68  ? 152 ILE A N    1 
ATOM   3160 C CA   . ILE B 1 152 ? 119.851 100.787 138.376 1.00 47.24  ? 152 ILE A CA   1 
ATOM   3161 C C    . ILE B 1 152 ? 121.322 100.394 138.428 1.00 51.36  ? 152 ILE A C    1 
ATOM   3162 O O    . ILE B 1 152 ? 121.658 99.273  138.828 1.00 53.16  ? 152 ILE A O    1 
ATOM   3163 C CB   . ILE B 1 152 ? 119.203 100.438 137.020 1.00 49.04  ? 152 ILE A CB   1 
ATOM   3164 C CG1  . ILE B 1 152 ? 118.947 98.932  136.924 1.00 49.66  ? 152 ILE A CG1  1 
ATOM   3165 C CG2  . ILE B 1 152 ? 120.054 100.900 135.850 1.00 45.98  ? 152 ILE A CG2  1 
ATOM   3166 C CD1  . ILE B 1 152 ? 117.966 98.414  137.951 1.00 52.18  ? 152 ILE A CD1  1 
ATOM   3167 N N    . ILE B 1 153 ? 122.228 101.301 138.048 1.00 55.97  ? 153 ILE A N    1 
ATOM   3168 C CA   . ILE B 1 153 ? 123.656 101.008 138.139 1.00 51.77  ? 153 ILE A CA   1 
ATOM   3169 C C    . ILE B 1 153 ? 124.055 100.811 139.596 1.00 54.22  ? 153 ILE A C    1 
ATOM   3170 O O    . ILE B 1 153 ? 124.785 99.869  139.940 1.00 57.12  ? 153 ILE A O    1 
ATOM   3171 C CB   . ILE B 1 153 ? 124.480 102.121 137.468 1.00 48.51  ? 153 ILE A CB   1 
ATOM   3172 C CG1  . ILE B 1 153 ? 124.444 101.963 135.947 1.00 51.38  ? 153 ILE A CG1  1 
ATOM   3173 C CG2  . ILE B 1 153 ? 125.914 102.109 137.974 1.00 49.64  ? 153 ILE A CG2  1 
ATOM   3174 C CD1  . ILE B 1 153 ? 125.362 102.916 135.216 1.00 52.44  ? 153 ILE A CD1  1 
ATOM   3175 N N    . ALA B 1 154 ? 123.582 101.699 140.473 1.00 62.72  ? 154 ALA A N    1 
ATOM   3176 C CA   . ALA B 1 154 ? 123.886 101.557 141.892 1.00 60.33  ? 154 ALA A CA   1 
ATOM   3177 C C    . ALA B 1 154 ? 123.336 100.250 142.448 1.00 57.79  ? 154 ALA A C    1 
ATOM   3178 O O    . ALA B 1 154 ? 124.016 99.557  143.216 1.00 62.84  ? 154 ALA A O    1 
ATOM   3179 C CB   . ALA B 1 154 ? 123.329 102.748 142.671 1.00 61.24  ? 154 ALA A CB   1 
ATOM   3180 N N    . TYR B 1 155 ? 122.104 99.896  142.071 1.00 66.93  ? 155 TYR A N    1 
ATOM   3181 C CA   . TYR B 1 155 ? 121.514 98.649  142.557 1.00 70.42  ? 155 TYR A CA   1 
ATOM   3182 C C    . TYR B 1 155 ? 122.309 97.439  142.078 1.00 70.19  ? 155 TYR A C    1 
ATOM   3183 O O    . TYR B 1 155 ? 122.556 96.503  142.850 1.00 70.19  ? 155 TYR A O    1 
ATOM   3184 C CB   . TYR B 1 155 ? 120.054 98.551  142.110 1.00 69.38  ? 155 TYR A CB   1 
ATOM   3185 C CG   . TYR B 1 155 ? 119.212 97.592  142.928 1.00 72.14  ? 155 TYR A CG   1 
ATOM   3186 C CD1  . TYR B 1 155 ? 119.432 96.221  142.879 1.00 72.17  ? 155 TYR A CD1  1 
ATOM   3187 C CD2  . TYR B 1 155 ? 118.196 98.061  143.752 1.00 73.28  ? 155 TYR A CD2  1 
ATOM   3188 C CE1  . TYR B 1 155 ? 118.666 95.346  143.622 1.00 73.65  ? 155 TYR A CE1  1 
ATOM   3189 C CE2  . TYR B 1 155 ? 117.423 97.191  144.500 1.00 75.57  ? 155 TYR A CE2  1 
ATOM   3190 C CZ   . TYR B 1 155 ? 117.663 95.836  144.434 1.00 77.13  ? 155 TYR A CZ   1 
ATOM   3191 O OH   . TYR B 1 155 ? 116.897 94.969  145.175 1.00 74.02  ? 155 TYR A OH   1 
ATOM   3192 N N    . ILE B 1 156 ? 122.728 97.446  140.809 1.00 69.39  ? 156 ILE A N    1 
ATOM   3193 C CA   . ILE B 1 156 ? 123.499 96.331  140.267 1.00 68.05  ? 156 ILE A CA   1 
ATOM   3194 C C    . ILE B 1 156 ? 124.827 96.201  141.002 1.00 68.79  ? 156 ILE A C    1 
ATOM   3195 O O    . ILE B 1 156 ? 125.250 95.099  141.369 1.00 67.63  ? 156 ILE A O    1 
ATOM   3196 C CB   . ILE B 1 156 ? 123.703 96.505  138.749 1.00 66.18  ? 156 ILE A CB   1 
ATOM   3197 C CG1  . ILE B 1 156 ? 122.484 95.988  137.986 1.00 68.03  ? 156 ILE A CG1  1 
ATOM   3198 C CG2  . ILE B 1 156 ? 124.962 95.788  138.285 1.00 65.86  ? 156 ILE A CG2  1 
ATOM   3199 C CD1  . ILE B 1 156 ? 122.302 96.624  136.624 1.00 67.14  ? 156 ILE A CD1  1 
ATOM   3200 N N    . MET B 1 157 ? 125.508 97.328  141.222 1.00 81.50  ? 157 MET A N    1 
ATOM   3201 C CA   . MET B 1 157 ? 126.793 97.284  141.915 1.00 80.43  ? 157 MET A CA   1 
ATOM   3202 C C    . MET B 1 157 ? 126.631 96.771  143.341 1.00 80.59  ? 157 MET A C    1 
ATOM   3203 O O    . MET B 1 157 ? 127.438 95.958  143.811 1.00 80.71  ? 157 MET A O    1 
ATOM   3204 C CB   . MET B 1 157 ? 127.446 98.664  141.909 1.00 77.34  ? 157 MET A CB   1 
ATOM   3205 C CG   . MET B 1 157 ? 128.466 98.861  140.801 1.00 79.89  ? 157 MET A CG   1 
ATOM   3206 S SD   . MET B 1 157 ? 128.976 100.579 140.601 1.00 91.19  ? 157 MET A SD   1 
ATOM   3207 C CE   . MET B 1 157 ? 128.881 101.163 142.292 1.00 81.97  ? 157 MET A CE   1 
ATOM   3208 N N    . LYS B 1 158 ? 125.597 97.238  144.046 1.00 86.86  ? 158 LYS A N    1 
ATOM   3209 C CA   . LYS B 1 158 ? 125.370 96.776  145.413 1.00 87.21  ? 158 LYS A CA   1 
ATOM   3210 C C    . LYS B 1 158 ? 125.078 95.282  145.449 1.00 88.04  ? 158 LYS A C    1 
ATOM   3211 O O    . LYS B 1 158 ? 125.605 94.560  146.304 1.00 89.44  ? 158 LYS A O    1 
ATOM   3212 C CB   . LYS B 1 158 ? 124.224 97.563  146.049 1.00 86.22  ? 158 LYS A CB   1 
ATOM   3213 C CG   . LYS B 1 158 ? 124.048 97.312  147.540 1.00 87.29  ? 158 LYS A CG   1 
ATOM   3214 C CD   . LYS B 1 158 ? 122.887 96.370  147.814 1.00 86.55  ? 158 LYS A CD   1 
ATOM   3215 C CE   . LYS B 1 158 ? 122.709 96.134  149.306 1.00 86.00  ? 158 LYS A CE   1 
ATOM   3216 N NZ   . LYS B 1 158 ? 122.421 97.397  150.037 1.00 86.19  ? 158 LYS A NZ   1 
ATOM   3217 N N    . SER B 1 159 ? 124.247 94.795  144.524 1.00 89.60  ? 159 SER A N    1 
ATOM   3218 C CA   . SER B 1 159 ? 123.933 93.369  144.495 1.00 90.27  ? 159 SER A CA   1 
ATOM   3219 C C    . SER B 1 159 ? 125.175 92.543  144.182 1.00 90.29  ? 159 SER A C    1 
ATOM   3220 O O    . SER B 1 159 ? 125.396 91.487  144.790 1.00 90.35  ? 159 SER A O    1 
ATOM   3221 C CB   . SER B 1 159 ? 122.832 93.092  143.472 1.00 91.60  ? 159 SER A CB   1 
ATOM   3222 O OG   . SER B 1 159 ? 122.525 91.710  143.415 1.00 91.66  ? 159 SER A OG   1 
ATOM   3223 N N    . CYS B 1 160 ? 125.997 93.010  143.238 1.00 94.91  ? 160 CYS A N    1 
ATOM   3224 C CA   . CYS B 1 160 ? 127.216 92.286  142.896 1.00 96.42  ? 160 CYS A CA   1 
ATOM   3225 C C    . CYS B 1 160 ? 128.171 92.223  144.081 1.00 95.65  ? 160 CYS A C    1 
ATOM   3226 O O    . CYS B 1 160 ? 128.748 91.167  144.366 1.00 95.53  ? 160 CYS A O    1 
ATOM   3227 C CB   . CYS B 1 160 ? 127.894 92.941  141.694 1.00 96.14  ? 160 CYS A CB   1 
ATOM   3228 S SG   . CYS B 1 160 ? 129.387 92.094  141.125 1.00 95.47  ? 160 CYS A SG   1 
ATOM   3229 N N    . HIS B 1 161 ? 128.348 93.346  144.785 1.00 101.02 ? 161 HIS A N    1 
ATOM   3230 C CA   . HIS B 1 161 ? 129.222 93.348  145.955 1.00 102.90 ? 161 HIS A CA   1 
ATOM   3231 C C    . HIS B 1 161 ? 128.690 92.423  147.042 1.00 102.74 ? 161 HIS A C    1 
ATOM   3232 O O    . HIS B 1 161 ? 129.458 91.676  147.664 1.00 101.76 ? 161 HIS A O    1 
ATOM   3233 C CB   . HIS B 1 161 ? 129.382 94.771  146.492 1.00 101.93 ? 161 HIS A CB   1 
ATOM   3234 C CG   . HIS B 1 161 ? 130.223 94.859  147.727 1.00 101.52 ? 161 HIS A CG   1 
ATOM   3235 N ND1  . HIS B 1 161 ? 129.715 94.652  148.990 1.00 101.74 ? 161 HIS A ND1  1 
ATOM   3236 C CD2  . HIS B 1 161 ? 131.541 95.131  147.890 1.00 101.26 ? 161 HIS A CD2  1 
ATOM   3237 C CE1  . HIS B 1 161 ? 130.682 94.791  149.880 1.00 102.18 ? 161 HIS A CE1  1 
ATOM   3238 N NE2  . HIS B 1 161 ? 131.799 95.083  149.238 1.00 103.48 ? 161 HIS A NE2  1 
ATOM   3239 N N    . GLN B 1 162 ? 127.376 92.454  147.284 1.00 106.02 ? 162 GLN A N    1 
ATOM   3240 C CA   . GLN B 1 162 ? 126.800 91.598  148.315 1.00 106.42 ? 162 GLN A CA   1 
ATOM   3241 C C    . GLN B 1 162 ? 126.976 90.127  147.968 1.00 106.62 ? 162 GLN A C    1 
ATOM   3242 O O    . GLN B 1 162 ? 127.287 89.306  148.840 1.00 106.01 ? 162 GLN A O    1 
ATOM   3243 C CB   . GLN B 1 162 ? 125.321 91.931  148.517 1.00 105.98 ? 162 GLN A CB   1 
ATOM   3244 C CG   . GLN B 1 162 ? 124.765 91.486  149.861 1.00 105.93 ? 162 GLN A CG   1 
ATOM   3245 C CD   . GLN B 1 162 ? 124.297 90.043  149.855 1.00 107.41 ? 162 GLN A CD   1 
ATOM   3246 O OE1  . GLN B 1 162 ? 124.051 89.463  148.798 1.00 107.75 ? 162 GLN A OE1  1 
ATOM   3247 N NE2  . GLN B 1 162 ? 124.177 89.455  151.040 1.00 106.24 ? 162 GLN A NE2  1 
ATOM   3248 N N    . ALA B 1 188 ? 120.985 102.958 147.759 1.00 87.98  ? 188 ALA A N    1 
ATOM   3249 C CA   . ALA B 1 188 ? 121.183 103.662 149.019 1.00 91.47  ? 188 ALA A CA   1 
ATOM   3250 C C    . ALA B 1 188 ? 122.496 104.440 149.011 1.00 92.85  ? 188 ALA A C    1 
ATOM   3251 O O    . ALA B 1 188 ? 122.628 105.447 148.318 1.00 90.41  ? 188 ALA A O    1 
ATOM   3252 C CB   . ALA B 1 188 ? 121.150 102.683 150.183 1.00 88.08  ? 188 ALA A CB   1 
ATOM   3253 N N    . GLY B 1 189 ? 123.466 103.965 149.788 1.00 90.77  ? 189 GLY A N    1 
ATOM   3254 C CA   . GLY B 1 189 ? 124.750 104.630 149.889 1.00 88.41  ? 189 GLY A CA   1 
ATOM   3255 C C    . GLY B 1 189 ? 125.778 104.069 148.927 1.00 88.25  ? 189 GLY A C    1 
ATOM   3256 O O    . GLY B 1 189 ? 126.984 104.270 149.107 1.00 86.03  ? 189 GLY A O    1 
ATOM   3257 N N    . TRP B 1 190 ? 125.306 103.358 147.903 1.00 86.54  ? 190 TRP A N    1 
ATOM   3258 C CA   . TRP B 1 190 ? 126.167 102.729 146.908 1.00 83.35  ? 190 TRP A CA   1 
ATOM   3259 C C    . TRP B 1 190 ? 126.165 103.480 145.583 1.00 82.45  ? 190 TRP A C    1 
ATOM   3260 O O    . TRP B 1 190 ? 126.327 102.869 144.521 1.00 85.62  ? 190 TRP A O    1 
ATOM   3261 C CB   . TRP B 1 190 ? 125.747 101.275 146.691 1.00 83.53  ? 190 TRP A CB   1 
ATOM   3262 C CG   . TRP B 1 190 ? 125.764 100.448 147.939 1.00 87.07  ? 190 TRP A CG   1 
ATOM   3263 C CD1  . TRP B 1 190 ? 124.827 100.440 148.931 1.00 86.41  ? 190 TRP A CD1  1 
ATOM   3264 C CD2  . TRP B 1 190 ? 126.769 99.505  148.329 1.00 88.28  ? 190 TRP A CD2  1 
ATOM   3265 N NE1  . TRP B 1 190 ? 125.186 99.551  149.917 1.00 85.42  ? 190 TRP A NE1  1 
ATOM   3266 C CE2  . TRP B 1 190 ? 126.374 98.964  149.570 1.00 87.75  ? 190 TRP A CE2  1 
ATOM   3267 C CE3  . TRP B 1 190 ? 127.961 99.062  147.752 1.00 87.15  ? 190 TRP A CE3  1 
ATOM   3268 C CZ2  . TRP B 1 190 ? 127.131 98.005  150.241 1.00 87.21  ? 190 TRP A CZ2  1 
ATOM   3269 C CZ3  . TRP B 1 190 ? 128.713 98.113  148.418 1.00 86.59  ? 190 TRP A CZ3  1 
ATOM   3270 C CH2  . TRP B 1 190 ? 128.296 97.595  149.650 1.00 87.27  ? 190 TRP A CH2  1 
ATOM   3271 N N    . LYS B 1 191 ? 125.982 104.796 145.622 1.00 71.66  ? 191 LYS A N    1 
ATOM   3272 C CA   . LYS B 1 191 ? 125.964 105.580 144.391 1.00 72.55  ? 191 LYS A CA   1 
ATOM   3273 C C    . LYS B 1 191 ? 127.349 105.592 143.752 1.00 72.11  ? 191 LYS A C    1 
ATOM   3274 O O    . LYS B 1 191 ? 128.342 105.868 144.439 1.00 74.33  ? 191 LYS A O    1 
ATOM   3275 C CB   . LYS B 1 191 ? 125.506 107.007 144.678 1.00 73.44  ? 191 LYS A CB   1 
ATOM   3276 C CG   . LYS B 1 191 ? 124.048 107.125 145.095 1.00 76.81  ? 191 LYS A CG   1 
ATOM   3277 C CD   . LYS B 1 191 ? 123.114 106.747 143.957 1.00 74.58  ? 191 LYS A CD   1 
ATOM   3278 C CE   . LYS B 1 191 ? 121.657 106.927 144.358 1.00 73.14  ? 191 LYS A CE   1 
ATOM   3279 N NZ   . LYS B 1 191 ? 120.730 106.595 143.242 1.00 71.37  ? 191 LYS A NZ   1 
ATOM   3280 N N    . PRO B 1 192 ? 127.459 105.301 142.460 1.00 65.92  ? 192 PRO A N    1 
ATOM   3281 C CA   . PRO B 1 192 ? 128.765 105.345 141.797 1.00 66.91  ? 192 PRO A CA   1 
ATOM   3282 C C    . PRO B 1 192 ? 129.283 106.769 141.670 1.00 65.87  ? 192 PRO A C    1 
ATOM   3283 O O    . PRO B 1 192 ? 128.525 107.744 141.665 1.00 66.80  ? 192 PRO A O    1 
ATOM   3284 C CB   . PRO B 1 192 ? 128.484 104.730 140.422 1.00 64.17  ? 192 PRO A CB   1 
ATOM   3285 C CG   . PRO B 1 192 ? 127.042 105.020 140.183 1.00 62.31  ? 192 PRO A CG   1 
ATOM   3286 C CD   . PRO B 1 192 ? 126.376 104.937 141.530 1.00 63.37  ? 192 PRO A CD   1 
ATOM   3287 N N    . SER B 1 193 ? 130.606 106.880 141.569 1.00 57.63  ? 193 SER A N    1 
ATOM   3288 C CA   . SER B 1 193 ? 131.223 108.182 141.374 1.00 54.48  ? 193 SER A CA   1 
ATOM   3289 C C    . SER B 1 193 ? 131.003 108.660 139.936 1.00 56.37  ? 193 SER A C    1 
ATOM   3290 O O    . SER B 1 193 ? 130.545 107.917 139.064 1.00 61.26  ? 193 SER A O    1 
ATOM   3291 C CB   . SER B 1 193 ? 132.714 108.125 141.695 1.00 56.05  ? 193 SER A CB   1 
ATOM   3292 O OG   . SER B 1 193 ? 133.386 107.213 140.844 1.00 58.18  ? 193 SER A OG   1 
ATOM   3293 N N    . VAL B 1 194 ? 131.346 109.927 139.693 1.00 45.07  ? 194 VAL A N    1 
ATOM   3294 C CA   . VAL B 1 194 ? 131.150 110.512 138.369 1.00 47.15  ? 194 VAL A CA   1 
ATOM   3295 C C    . VAL B 1 194 ? 132.075 109.863 137.344 1.00 50.52  ? 194 VAL A C    1 
ATOM   3296 O O    . VAL B 1 194 ? 131.695 109.667 136.183 1.00 54.75  ? 194 VAL A O    1 
ATOM   3297 C CB   . VAL B 1 194 ? 131.356 112.035 138.441 1.00 47.87  ? 194 VAL A CB   1 
ATOM   3298 C CG1  . VAL B 1 194 ? 131.054 112.682 137.104 1.00 46.57  ? 194 VAL A CG1  1 
ATOM   3299 C CG2  . VAL B 1 194 ? 130.490 112.638 139.537 1.00 48.64  ? 194 VAL A CG2  1 
ATOM   3300 N N    . TYR B 1 195 ? 133.300 109.525 137.752 1.00 49.99  ? 195 TYR A N    1 
ATOM   3301 C CA   . TYR B 1 195 ? 134.268 108.934 136.831 1.00 49.97  ? 195 TYR A CA   1 
ATOM   3302 C C    . TYR B 1 195 ? 133.776 107.592 136.296 1.00 57.01  ? 195 TYR A C    1 
ATOM   3303 O O    . TYR B 1 195 ? 133.850 107.321 135.088 1.00 59.36  ? 195 TYR A O    1 
ATOM   3304 C CB   . TYR B 1 195 ? 135.616 108.785 137.537 1.00 50.71  ? 195 TYR A CB   1 
ATOM   3305 C CG   . TYR B 1 195 ? 136.762 108.352 136.656 1.00 57.20  ? 195 TYR A CG   1 
ATOM   3306 C CD1  . TYR B 1 195 ? 137.256 109.191 135.665 1.00 57.68  ? 195 TYR A CD1  1 
ATOM   3307 C CD2  . TYR B 1 195 ? 137.369 107.114 136.827 1.00 54.34  ? 195 TYR A CD2  1 
ATOM   3308 C CE1  . TYR B 1 195 ? 138.310 108.805 134.861 1.00 59.43  ? 195 TYR A CE1  1 
ATOM   3309 C CE2  . TYR B 1 195 ? 138.425 106.720 136.026 1.00 52.11  ? 195 TYR A CE2  1 
ATOM   3310 C CZ   . TYR B 1 195 ? 138.890 107.567 135.045 1.00 58.69  ? 195 TYR A CZ   1 
ATOM   3311 O OH   . TYR B 1 195 ? 139.939 107.179 134.246 1.00 61.04  ? 195 TYR A OH   1 
ATOM   3312 N N    . TYR B 1 196 ? 133.257 106.742 137.186 1.00 52.91  ? 196 TYR A N    1 
ATOM   3313 C CA   . TYR B 1 196 ? 132.777 105.428 136.767 1.00 51.44  ? 196 TYR A CA   1 
ATOM   3314 C C    . TYR B 1 196 ? 131.549 105.546 135.874 1.00 51.51  ? 196 TYR A C    1 
ATOM   3315 O O    . TYR B 1 196 ? 131.407 104.793 134.905 1.00 58.64  ? 196 TYR A O    1 
ATOM   3316 C CB   . TYR B 1 196 ? 132.474 104.570 137.994 1.00 51.18  ? 196 TYR A CB   1 
ATOM   3317 C CG   . TYR B 1 196 ? 133.707 104.168 138.775 1.00 59.22  ? 196 TYR A CG   1 
ATOM   3318 C CD1  . TYR B 1 196 ? 134.954 104.119 138.166 1.00 58.32  ? 196 TYR A CD1  1 
ATOM   3319 C CD2  . TYR B 1 196 ? 133.624 103.845 140.122 1.00 60.59  ? 196 TYR A CD2  1 
ATOM   3320 C CE1  . TYR B 1 196 ? 136.081 103.755 138.876 1.00 56.11  ? 196 TYR A CE1  1 
ATOM   3321 C CE2  . TYR B 1 196 ? 134.746 103.482 140.840 1.00 59.78  ? 196 TYR A CE2  1 
ATOM   3322 C CZ   . TYR B 1 196 ? 135.972 103.437 140.212 1.00 60.18  ? 196 TYR A CZ   1 
ATOM   3323 O OH   . TYR B 1 196 ? 137.095 103.074 140.922 1.00 60.10  ? 196 TYR A OH   1 
ATOM   3324 N N    . VAL B 1 197 ? 130.649 106.480 136.192 1.00 40.17  ? 197 VAL A N    1 
ATOM   3325 C CA   . VAL B 1 197 ? 129.483 106.705 135.342 1.00 40.33  ? 197 VAL A CA   1 
ATOM   3326 C C    . VAL B 1 197 ? 129.918 107.163 133.956 1.00 42.69  ? 197 VAL A C    1 
ATOM   3327 O O    . VAL B 1 197 ? 129.359 106.732 132.943 1.00 47.40  ? 197 VAL A O    1 
ATOM   3328 C CB   . VAL B 1 197 ? 128.523 107.716 135.999 1.00 42.74  ? 197 VAL A CB   1 
ATOM   3329 C CG1  . VAL B 1 197 ? 127.363 108.027 135.072 1.00 40.58  ? 197 VAL A CG1  1 
ATOM   3330 C CG2  . VAL B 1 197 ? 128.004 107.164 137.313 1.00 45.20  ? 197 VAL A CG2  1 
ATOM   3331 N N    . MET B 1 198 ? 130.923 108.039 133.891 1.00 46.64  ? 198 MET A N    1 
ATOM   3332 C CA   . MET B 1 198 ? 131.423 108.483 132.596 1.00 42.82  ? 198 MET A CA   1 
ATOM   3333 C C    . MET B 1 198 ? 132.010 107.323 131.801 1.00 46.07  ? 198 MET A C    1 
ATOM   3334 O O    . MET B 1 198 ? 131.762 107.194 130.594 1.00 55.52  ? 198 MET A O    1 
ATOM   3335 C CB   . MET B 1 198 ? 132.467 109.584 132.784 1.00 45.76  ? 198 MET A CB   1 
ATOM   3336 C CG   . MET B 1 198 ? 132.645 110.484 131.576 1.00 52.50  ? 198 MET A CG   1 
ATOM   3337 S SD   . MET B 1 198 ? 134.332 111.077 131.376 1.00 67.48  ? 198 MET A SD   1 
ATOM   3338 C CE   . MET B 1 198 ? 135.251 109.554 131.572 1.00 51.57  ? 198 MET A CE   1 
ATOM   3339 N N    . LEU B 1 199 ? 132.787 106.460 132.462 1.00 42.40  ? 199 LEU A N    1 
ATOM   3340 C CA   . LEU B 1 199 ? 133.363 105.309 131.766 1.00 42.85  ? 199 LEU A CA   1 
ATOM   3341 C C    . LEU B 1 199 ? 132.276 104.363 131.259 1.00 45.54  ? 199 LEU A C    1 
ATOM   3342 O O    . LEU B 1 199 ? 132.348 103.869 130.124 1.00 49.46  ? 199 LEU A O    1 
ATOM   3343 C CB   . LEU B 1 199 ? 134.334 104.567 132.687 1.00 39.34  ? 199 LEU A CB   1 
ATOM   3344 C CG   . LEU B 1 199 ? 135.575 105.334 133.142 1.00 44.89  ? 199 LEU A CG   1 
ATOM   3345 C CD1  . LEU B 1 199 ? 136.520 104.418 133.908 1.00 47.01  ? 199 LEU A CD1  1 
ATOM   3346 C CD2  . LEU B 1 199 ? 136.286 105.964 131.956 1.00 44.24  ? 199 LEU A CD2  1 
ATOM   3347 N N    . ILE B 1 200 ? 131.260 104.107 132.084 1.00 41.08  ? 200 ILE A N    1 
ATOM   3348 C CA   . ILE B 1 200 ? 130.177 103.212 131.688 1.00 36.62  ? 200 ILE A CA   1 
ATOM   3349 C C    . ILE B 1 200 ? 129.392 103.802 130.522 1.00 38.37  ? 200 ILE A C    1 
ATOM   3350 O O    . ILE B 1 200 ? 129.018 103.091 129.582 1.00 41.13  ? 200 ILE A O    1 
ATOM   3351 C CB   . ILE B 1 200 ? 129.267 102.914 132.893 1.00 35.94  ? 200 ILE A CB   1 
ATOM   3352 C CG1  . ILE B 1 200 ? 129.993 102.021 133.897 1.00 39.54  ? 200 ILE A CG1  1 
ATOM   3353 C CG2  . ILE B 1 200 ? 127.966 102.261 132.446 1.00 34.88  ? 200 ILE A CG2  1 
ATOM   3354 C CD1  . ILE B 1 200 ? 129.183 101.711 135.131 1.00 36.62  ? 200 ILE A CD1  1 
ATOM   3355 N N    . LEU B 1 201 ? 129.126 105.113 130.562 1.00 35.03  ? 201 LEU A N    1 
ATOM   3356 C CA   . LEU B 1 201 ? 128.420 105.757 129.463 1.00 32.38  ? 201 LEU A CA   1 
ATOM   3357 C C    . LEU B 1 201 ? 129.236 105.714 128.178 1.00 39.01  ? 201 LEU A C    1 
ATOM   3358 O O    . LEU B 1 201 ? 128.682 105.512 127.092 1.00 44.84  ? 201 LEU A O    1 
ATOM   3359 C CB   . LEU B 1 201 ? 128.079 107.200 129.838 1.00 33.01  ? 201 LEU A CB   1 
ATOM   3360 C CG   . LEU B 1 201 ? 126.893 107.379 130.789 1.00 34.11  ? 201 LEU A CG   1 
ATOM   3361 C CD1  . LEU B 1 201 ? 126.786 108.822 131.246 1.00 36.56  ? 201 LEU A CD1  1 
ATOM   3362 C CD2  . LEU B 1 201 ? 125.603 106.921 130.131 1.00 35.49  ? 201 LEU A CD2  1 
ATOM   3363 N N    . CYS B 1 202 ? 130.555 105.893 128.278 1.00 42.66  ? 202 CYS A N    1 
ATOM   3364 C CA   . CYS B 1 202 ? 131.405 105.797 127.095 1.00 37.35  ? 202 CYS A CA   1 
ATOM   3365 C C    . CYS B 1 202 ? 131.353 104.396 126.497 1.00 41.53  ? 202 CYS A C    1 
ATOM   3366 O O    . CYS B 1 202 ? 131.222 104.231 125.275 1.00 44.38  ? 202 CYS A O    1 
ATOM   3367 C CB   . CYS B 1 202 ? 132.843 106.173 127.454 1.00 35.77  ? 202 CYS A CB   1 
ATOM   3368 S SG   . CYS B 1 202 ? 133.122 107.935 127.731 1.00 58.46  ? 202 CYS A SG   1 
ATOM   3369 N N    . THR B 1 203 ? 131.452 103.370 127.347 1.00 39.67  ? 203 THR A N    1 
ATOM   3370 C CA   . THR B 1 203 ? 131.381 101.994 126.856 1.00 34.70  ? 203 THR A CA   1 
ATOM   3371 C C    . THR B 1 203 ? 130.033 101.701 126.211 1.00 41.71  ? 203 THR A C    1 
ATOM   3372 O O    . THR B 1 203 ? 129.965 101.072 125.146 1.00 43.11  ? 203 THR A O    1 
ATOM   3373 C CB   . THR B 1 203 ? 131.655 101.014 127.997 1.00 34.23  ? 203 THR A CB   1 
ATOM   3374 O OG1  . THR B 1 203 ? 132.620 101.576 128.894 1.00 47.44  ? 203 THR A OG1  1 
ATOM   3375 C CG2  . THR B 1 203 ? 132.183 99.697  127.453 1.00 36.62  ? 203 THR A CG2  1 
ATOM   3376 N N    . ALA B 1 204 ? 128.944 102.155 126.839 1.00 43.04  ? 204 ALA A N    1 
ATOM   3377 C CA   . ALA B 1 204 ? 127.616 101.935 126.276 1.00 34.82  ? 204 ALA A CA   1 
ATOM   3378 C C    . ALA B 1 204 ? 127.466 102.628 124.929 1.00 40.62  ? 204 ALA A C    1 
ATOM   3379 O O    . ALA B 1 204 ? 126.907 102.055 123.989 1.00 48.58  ? 204 ALA A O    1 
ATOM   3380 C CB   . ALA B 1 204 ? 126.545 102.423 127.253 1.00 35.87  ? 204 ALA A CB   1 
ATOM   3381 N N    . SER B 1 205 ? 127.957 103.865 124.822 1.00 41.16  ? 205 SER A N    1 
ATOM   3382 C CA   . SER B 1 205 ? 127.864 104.591 123.561 1.00 39.14  ? 205 SER A CA   1 
ATOM   3383 C C    . SER B 1 205 ? 128.647 103.887 122.465 1.00 39.06  ? 205 SER A C    1 
ATOM   3384 O O    . SER B 1 205 ? 128.164 103.758 121.333 1.00 40.59  ? 205 SER A O    1 
ATOM   3385 C CB   . SER B 1 205 ? 128.367 106.023 123.745 1.00 34.83  ? 205 SER A CB   1 
ATOM   3386 O OG   . SER B 1 205 ? 127.674 106.679 124.792 1.00 41.27  ? 205 SER A OG   1 
ATOM   3387 N N    . ILE B 1 206 ? 129.855 103.415 122.785 1.00 39.55  ? 206 ILE A N    1 
ATOM   3388 C CA   . ILE B 1 206 ? 130.666 102.715 121.792 1.00 36.43  ? 206 ILE A CA   1 
ATOM   3389 C C    . ILE B 1 206 ? 129.966 101.439 121.332 1.00 39.28  ? 206 ILE A C    1 
ATOM   3390 O O    . ILE B 1 206 ? 129.896 101.147 120.129 1.00 46.29  ? 206 ILE A O    1 
ATOM   3391 C CB   . ILE B 1 206 ? 132.066 102.417 122.363 1.00 40.56  ? 206 ILE A CB   1 
ATOM   3392 C CG1  . ILE B 1 206 ? 132.879 103.709 122.475 1.00 41.82  ? 206 ILE A CG1  1 
ATOM   3393 C CG2  . ILE B 1 206 ? 132.798 101.404 121.494 1.00 38.05  ? 206 ILE A CG2  1 
ATOM   3394 C CD1  . ILE B 1 206 ? 134.286 103.502 122.978 1.00 42.73  ? 206 ILE A CD1  1 
ATOM   3395 N N    . LEU B 1 207 ? 129.427 100.664 122.281 1.00 37.88  ? 207 LEU A N    1 
ATOM   3396 C CA   . LEU B 1 207 ? 128.756 99.420  121.915 1.00 36.26  ? 207 LEU A CA   1 
ATOM   3397 C C    . LEU B 1 207 ? 127.526 99.682  121.055 1.00 40.89  ? 207 LEU A C    1 
ATOM   3398 O O    . LEU B 1 207 ? 127.298 98.992  120.053 1.00 42.15  ? 207 LEU A O    1 
ATOM   3399 C CB   . LEU B 1 207 ? 128.374 98.636  123.168 1.00 41.20  ? 207 LEU A CB   1 
ATOM   3400 C CG   . LEU B 1 207 ? 129.513 97.946  123.922 1.00 47.55  ? 207 LEU A CG   1 
ATOM   3401 C CD1  . LEU B 1 207 ? 128.973 97.190  125.122 1.00 41.22  ? 207 LEU A CD1  1 
ATOM   3402 C CD2  . LEU B 1 207 ? 130.279 97.012  123.003 1.00 41.67  ? 207 LEU A CD2  1 
ATOM   3403 N N    . ILE B 1 208 ? 126.726 100.687 121.423 1.00 37.63  ? 208 ILE A N    1 
ATOM   3404 C CA   . ILE B 1 208 ? 125.513 100.993 120.668 1.00 36.81  ? 208 ILE A CA   1 
ATOM   3405 C C    . ILE B 1 208 ? 125.861 101.462 119.263 1.00 39.22  ? 208 ILE A C    1 
ATOM   3406 O O    . ILE B 1 208 ? 125.221 101.061 118.282 1.00 43.86  ? 208 ILE A O    1 
ATOM   3407 C CB   . ILE B 1 208 ? 124.657 102.031 121.422 1.00 36.10  ? 208 ILE A CB   1 
ATOM   3408 C CG1  . ILE B 1 208 ? 124.047 101.403 122.675 1.00 37.91  ? 208 ILE A CG1  1 
ATOM   3409 C CG2  . ILE B 1 208 ? 123.563 102.589 120.526 1.00 36.65  ? 208 ILE A CG2  1 
ATOM   3410 C CD1  . ILE B 1 208 ? 123.127 102.332 123.433 1.00 35.57  ? 208 ILE A CD1  1 
ATOM   3411 N N    . SER B 1 209 ? 126.878 102.317 119.140 1.00 42.10  ? 209 SER A N    1 
ATOM   3412 C CA   . SER B 1 209 ? 127.297 102.785 117.823 1.00 35.54  ? 209 SER A CA   1 
ATOM   3413 C C    . SER B 1 209 ? 127.797 101.638 116.952 1.00 34.74  ? 209 SER A C    1 
ATOM   3414 O O    . SER B 1 209 ? 127.442 101.550 115.770 1.00 43.22  ? 209 SER A O    1 
ATOM   3415 C CB   . SER B 1 209 ? 128.380 103.853 117.975 1.00 34.16  ? 209 SER A CB   1 
ATOM   3416 O OG   . SER B 1 209 ? 127.920 104.944 118.752 1.00 45.33  ? 209 SER A OG   1 
ATOM   3417 N N    . CYS B 1 210 ? 128.625 100.752 117.510 1.00 36.36  ? 210 CYS A N    1 
ATOM   3418 C CA   . CYS B 1 210 ? 129.135 99.635  116.717 1.00 35.95  ? 210 CYS A CA   1 
ATOM   3419 C C    . CYS B 1 210 ? 128.049 98.631  116.346 1.00 38.68  ? 210 CYS A C    1 
ATOM   3420 O O    . CYS B 1 210 ? 128.062 98.091  115.230 1.00 38.99  ? 210 CYS A O    1 
ATOM   3421 C CB   . CYS B 1 210 ? 130.261 98.927  117.472 1.00 35.13  ? 210 CYS A CB   1 
ATOM   3422 S SG   . CYS B 1 210 ? 131.827 99.829  117.516 1.00 50.02  ? 210 CYS A SG   1 
ATOM   3423 N N    . CYS B 1 211 ? 127.019 98.488  117.184 1.00 40.92  ? 211 CYS A N    1 
ATOM   3424 C CA   . CYS B 1 211 ? 125.911 97.609  116.828 1.00 40.58  ? 211 CYS A CA   1 
ATOM   3425 C C    . CYS B 1 211 ? 125.004 98.233  115.780 1.00 42.51  ? 211 CYS A C    1 
ATOM   3426 O O    . CYS B 1 211 ? 124.496 97.525  114.903 1.00 47.05  ? 211 CYS A O    1 
ATOM   3427 C CB   . CYS B 1 211 ? 125.106 97.244  118.076 1.00 44.46  ? 211 CYS A CB   1 
ATOM   3428 S SG   . CYS B 1 211 ? 125.877 95.986  119.117 1.00 58.51  ? 211 CYS A SG   1 
ATOM   3429 N N    . ALA B 1 212 ? 124.787 99.547  115.843 1.00 36.19  ? 212 ALA A N    1 
ATOM   3430 C CA   . ALA B 1 212 ? 123.975 100.177 114.810 1.00 32.31  ? 212 ALA A CA   1 
ATOM   3431 C C    . ALA B 1 212 ? 124.720 100.190 113.482 1.00 36.19  ? 212 ALA A C    1 
ATOM   3432 O O    . ALA B 1 212 ? 124.112 100.005 112.421 1.00 32.49  ? 212 ALA A O    1 
ATOM   3433 C CB   . ALA B 1 212 ? 123.587 101.592 115.234 1.00 25.89  ? 212 ALA A CB   1 
ATOM   3434 N N    . SER B 1 213 ? 126.033 100.434 113.522 1.00 32.63  ? 213 SER A N    1 
ATOM   3435 C CA   . SER B 1 213 ? 126.841 100.428 112.309 1.00 24.26  ? 213 SER A CA   1 
ATOM   3436 C C    . SER B 1 213 ? 126.879 99.048  111.664 1.00 32.18  ? 213 SER A C    1 
ATOM   3437 O O    . SER B 1 213 ? 126.868 98.934  110.433 1.00 38.03  ? 213 SER A O    1 
ATOM   3438 C CB   . SER B 1 213 ? 128.257 100.913 112.623 1.00 30.81  ? 213 SER A CB   1 
ATOM   3439 O OG   . SER B 1 213 ? 128.227 102.013 113.514 1.00 36.75  ? 213 SER A OG   1 
ATOM   3440 N N    . ALA B 1 214 ? 126.900 97.984  112.477 1.00 35.01  ? 214 ALA A N    1 
ATOM   3441 C CA   . ALA B 1 214 ? 126.913 96.637  111.914 1.00 31.41  ? 214 ALA A CA   1 
ATOM   3442 C C    . ALA B 1 214 ? 125.641 96.309  111.140 1.00 34.74  ? 214 ALA A C    1 
ATOM   3443 O O    . ALA B 1 214 ? 125.646 95.373  110.336 1.00 39.24  ? 214 ALA A O    1 
ATOM   3444 C CB   . ALA B 1 214 ? 127.122 95.606  113.025 1.00 27.37  ? 214 ALA A CB   1 
ATOM   3445 N N    . MET B 1 215 ? 124.562 97.057  111.352 1.00 34.38  ? 215 MET A N    1 
ATOM   3446 C CA   . MET B 1 215 ? 123.343 96.914  110.564 1.00 34.97  ? 215 MET A CA   1 
ATOM   3447 C C    . MET B 1 215 ? 123.258 97.931  109.434 1.00 36.87  ? 215 MET A C    1 
ATOM   3448 O O    . MET B 1 215 ? 122.808 97.595  108.334 1.00 37.00  ? 215 MET A O    1 
ATOM   3449 C CB   . MET B 1 215 ? 122.109 97.032  111.465 1.00 33.58  ? 215 MET A CB   1 
ATOM   3450 C CG   . MET B 1 215 ? 120.780 97.022  110.718 1.00 34.46  ? 215 MET A CG   1 
ATOM   3451 S SD   . MET B 1 215 ? 119.394 97.571  111.731 1.00 54.62  ? 215 MET A SD   1 
ATOM   3452 C CE   . MET B 1 215 ? 119.678 99.337  111.788 1.00 37.41  ? 215 MET A CE   1 
ATOM   3453 N N    . TYR B 1 216 ? 123.696 99.169  109.685 1.00 37.84  ? 216 TYR A N    1 
ATOM   3454 C CA   . TYR B 1 216 ? 123.668 100.202 108.654 1.00 26.58  ? 216 TYR A CA   1 
ATOM   3455 C C    . TYR B 1 216 ? 124.582 99.862  107.484 1.00 33.18  ? 216 TYR A C    1 
ATOM   3456 O O    . TYR B 1 216 ? 124.223 100.095 106.325 1.00 35.59  ? 216 TYR A O    1 
ATOM   3457 C CB   . TYR B 1 216 ? 124.060 101.555 109.252 1.00 24.63  ? 216 TYR A CB   1 
ATOM   3458 C CG   . TYR B 1 216 ? 123.014 102.171 110.152 1.00 27.89  ? 216 TYR A CG   1 
ATOM   3459 C CD1  . TYR B 1 216 ? 121.662 102.046 109.869 1.00 29.97  ? 216 TYR A CD1  1 
ATOM   3460 C CD2  . TYR B 1 216 ? 123.382 102.885 111.286 1.00 31.09  ? 216 TYR A CD2  1 
ATOM   3461 C CE1  . TYR B 1 216 ? 120.706 102.611 110.689 1.00 28.47  ? 216 TYR A CE1  1 
ATOM   3462 C CE2  . TYR B 1 216 ? 122.433 103.449 112.111 1.00 32.88  ? 216 TYR A CE2  1 
ATOM   3463 C CZ   . TYR B 1 216 ? 121.098 103.310 111.810 1.00 33.63  ? 216 TYR A CZ   1 
ATOM   3464 O OH   . TYR B 1 216 ? 120.149 103.872 112.629 1.00 37.45  ? 216 TYR A OH   1 
ATOM   3465 N N    . THR B 1 217 ? 125.770 99.319  107.760 1.00 34.79  ? 217 THR A N    1 
ATOM   3466 C CA   . THR B 1 217 ? 126.746 99.115  106.693 1.00 29.17  ? 217 THR A CA   1 
ATOM   3467 C C    . THR B 1 217 ? 126.265 98.152  105.612 1.00 30.65  ? 217 THR A C    1 
ATOM   3468 O O    . THR B 1 217 ? 126.375 98.495  104.423 1.00 35.48  ? 217 THR A O    1 
ATOM   3469 C CB   . THR B 1 217 ? 128.083 98.668  107.298 1.00 30.34  ? 217 THR A CB   1 
ATOM   3470 O OG1  . THR B 1 217 ? 128.778 99.807  107.824 1.00 37.14  ? 217 THR A OG1  1 
ATOM   3471 C CG2  . THR B 1 217 ? 128.953 98.006  106.244 1.00 31.26  ? 217 THR A CG2  1 
ATOM   3472 N N    . PRO B 1 218 ? 125.734 96.951  105.925 1.00 33.23  ? 218 PRO A N    1 
ATOM   3473 C CA   . PRO B 1 218 ? 125.287 96.062  104.843 1.00 27.36  ? 218 PRO A CA   1 
ATOM   3474 C C    . PRO B 1 218 ? 124.038 96.551  104.126 1.00 32.65  ? 218 PRO A C    1 
ATOM   3475 O O    . PRO B 1 218 ? 123.977 96.533  102.893 1.00 34.69  ? 218 PRO A O    1 
ATOM   3476 C CB   . PRO B 1 218 ? 125.018 94.740  105.574 1.00 29.16  ? 218 PRO A CB   1 
ATOM   3477 C CG   . PRO B 1 218 ? 125.855 94.828  106.801 1.00 34.54  ? 218 PRO A CG   1 
ATOM   3478 C CD   . PRO B 1 218 ? 125.673 96.250  107.216 1.00 33.75  ? 218 PRO A CD   1 
ATOM   3479 N N    . ILE B 1 219 ? 123.033 96.984  104.892 1.00 32.09  ? 219 ILE A N    1 
ATOM   3480 C CA   . ILE B 1 219 ? 121.759 97.378  104.295 1.00 29.74  ? 219 ILE A CA   1 
ATOM   3481 C C    . ILE B 1 219 ? 121.919 98.626  103.433 1.00 31.92  ? 219 ILE A C    1 
ATOM   3482 O O    . ILE B 1 219 ? 121.400 98.691  102.313 1.00 36.30  ? 219 ILE A O    1 
ATOM   3483 C CB   . ILE B 1 219 ? 120.701 97.578  105.395 1.00 30.55  ? 219 ILE A CB   1 
ATOM   3484 C CG1  . ILE B 1 219 ? 120.383 96.250  106.090 1.00 33.84  ? 219 ILE A CG1  1 
ATOM   3485 C CG2  . ILE B 1 219 ? 119.439 98.168  104.814 1.00 25.71  ? 219 ILE A CG2  1 
ATOM   3486 C CD1  . ILE B 1 219 ? 120.260 95.074  105.148 1.00 34.15  ? 219 ILE A CD1  1 
ATOM   3487 N N    . GLU B 1 220 ? 122.632 99.630  103.932 1.00 35.42  ? 220 GLU A N    1 
ATOM   3488 C CA   . GLU B 1 220 ? 122.940 100.803 103.132 1.00 30.16  ? 220 GLU A CA   1 
ATOM   3489 C C    . GLU B 1 220 ? 124.178 100.548 102.274 1.00 37.87  ? 220 GLU A C    1 
ATOM   3490 O O    . GLU B 1 220 ? 124.850 99.521  102.388 1.00 46.24  ? 220 GLU A O    1 
ATOM   3491 C CB   . GLU B 1 220 ? 123.156 102.024 104.020 1.00 29.46  ? 220 GLU A CB   1 
ATOM   3492 C CG   . GLU B 1 220 ? 122.040 102.269 105.020 1.00 31.28  ? 220 GLU A CG   1 
ATOM   3493 C CD   . GLU B 1 220 ? 121.046 103.305 104.546 1.00 40.74  ? 220 GLU A CD   1 
ATOM   3494 O OE1  . GLU B 1 220 ? 121.335 103.994 103.542 1.00 46.87  ? 220 GLU A OE1  1 
ATOM   3495 O OE2  . GLU B 1 220 ? 119.974 103.427 105.171 1.00 40.26  ? 220 GLU A OE2  1 
ATOM   3496 N N    . GLY B 1 221 ? 124.480 101.499 101.395 1.00 41.19  ? 221 GLY A N    1 
ATOM   3497 C CA   . GLY B 1 221 ? 125.729 101.444 100.662 1.00 41.29  ? 221 GLY A CA   1 
ATOM   3498 C C    . GLY B 1 221 ? 126.830 102.242 101.329 1.00 44.20  ? 221 GLY A C    1 
ATOM   3499 O O    . GLY B 1 221 ? 127.510 103.036 100.673 1.00 50.31  ? 221 GLY A O    1 
ATOM   3500 N N    . TRP B 1 222 ? 127.025 102.035 102.629 1.00 30.29  ? 222 TRP A N    1 
ATOM   3501 C CA   . TRP B 1 222 ? 127.925 102.855 103.425 1.00 31.53  ? 222 TRP A CA   1 
ATOM   3502 C C    . TRP B 1 222 ? 129.108 102.023 103.905 1.00 37.36  ? 222 TRP A C    1 
ATOM   3503 O O    . TRP B 1 222 ? 129.006 100.805 104.074 1.00 46.13  ? 222 TRP A O    1 
ATOM   3504 C CB   . TRP B 1 222 ? 127.208 103.462 104.637 1.00 27.86  ? 222 TRP A CB   1 
ATOM   3505 C CG   . TRP B 1 222 ? 126.126 104.447 104.298 1.00 31.70  ? 222 TRP A CG   1 
ATOM   3506 C CD1  . TRP B 1 222 ? 125.817 104.932 103.064 1.00 32.53  ? 222 TRP A CD1  1 
ATOM   3507 C CD2  . TRP B 1 222 ? 125.224 105.080 105.214 1.00 31.37  ? 222 TRP A CD2  1 
ATOM   3508 N NE1  . TRP B 1 222 ? 124.770 105.816 103.150 1.00 31.81  ? 222 TRP A NE1  1 
ATOM   3509 C CE2  . TRP B 1 222 ? 124.389 105.925 104.460 1.00 27.84  ? 222 TRP A CE2  1 
ATOM   3510 C CE3  . TRP B 1 222 ? 125.038 105.009 106.598 1.00 28.32  ? 222 TRP A CE3  1 
ATOM   3511 C CZ2  . TRP B 1 222 ? 123.385 106.697 105.042 1.00 30.01  ? 222 TRP A CZ2  1 
ATOM   3512 C CZ3  . TRP B 1 222 ? 124.037 105.774 107.174 1.00 24.37  ? 222 TRP A CZ3  1 
ATOM   3513 C CH2  . TRP B 1 222 ? 123.224 106.606 106.398 1.00 28.15  ? 222 TRP A CH2  1 
ATOM   3514 N N    . SER B 1 223 ? 130.238 102.694 104.112 1.00 29.91  ? 223 SER A N    1 
ATOM   3515 C CA   . SER B 1 223 ? 131.365 102.057 104.774 1.00 26.50  ? 223 SER A CA   1 
ATOM   3516 C C    . SER B 1 223 ? 131.179 102.106 106.290 1.00 33.07  ? 223 SER A C    1 
ATOM   3517 O O    . SER B 1 223 ? 130.326 102.827 106.816 1.00 41.45  ? 223 SER A O    1 
ATOM   3518 C CB   . SER B 1 223 ? 132.676 102.730 104.367 1.00 33.62  ? 223 SER A CB   1 
ATOM   3519 O OG   . SER B 1 223 ? 132.718 104.078 104.801 1.00 38.19  ? 223 SER A OG   1 
ATOM   3520 N N    . TYR B 1 224 ? 131.987 101.314 106.995 1.00 29.93  ? 224 TYR A N    1 
ATOM   3521 C CA   . TYR B 1 224 ? 131.868 101.248 108.449 1.00 30.76  ? 224 TYR A CA   1 
ATOM   3522 C C    . TYR B 1 224 ? 132.187 102.593 109.095 1.00 37.18  ? 224 TYR A C    1 
ATOM   3523 O O    . TYR B 1 224 ? 131.497 103.023 110.031 1.00 39.52  ? 224 TYR A O    1 
ATOM   3524 C CB   . TYR B 1 224 ? 132.786 100.156 109.001 1.00 31.04  ? 224 TYR A CB   1 
ATOM   3525 C CG   . TYR B 1 224 ? 132.386 99.663  110.370 1.00 39.71  ? 224 TYR A CG   1 
ATOM   3526 C CD1  . TYR B 1 224 ? 131.253 98.881  110.542 1.00 40.72  ? 224 TYR A CD1  1 
ATOM   3527 C CD2  . TYR B 1 224 ? 133.128 99.996  111.495 1.00 38.26  ? 224 TYR A CD2  1 
ATOM   3528 C CE1  . TYR B 1 224 ? 130.878 98.434  111.791 1.00 38.55  ? 224 TYR A CE1  1 
ATOM   3529 C CE2  . TYR B 1 224 ? 132.758 99.553  112.749 1.00 34.88  ? 224 TYR A CE2  1 
ATOM   3530 C CZ   . TYR B 1 224 ? 131.632 98.773  112.891 1.00 38.70  ? 224 TYR A CZ   1 
ATOM   3531 O OH   . TYR B 1 224 ? 131.261 98.329  114.137 1.00 41.09  ? 224 TYR A OH   1 
ATOM   3532 N N    . PHE B 1 225 ? 133.232 103.271 108.611 1.00 36.77  ? 225 PHE A N    1 
ATOM   3533 C CA   . PHE B 1 225 ? 133.598 104.571 109.166 1.00 34.30  ? 225 PHE A CA   1 
ATOM   3534 C C    . PHE B 1 225 ? 132.516 105.612 108.901 1.00 37.04  ? 225 PHE A C    1 
ATOM   3535 O O    . PHE B 1 225 ? 132.232 106.453 109.762 1.00 43.40  ? 225 PHE A O    1 
ATOM   3536 C CB   . PHE B 1 225 ? 134.943 105.025 108.599 1.00 35.99  ? 225 PHE A CB   1 
ATOM   3537 C CG   . PHE B 1 225 ? 135.370 106.384 109.073 1.00 42.68  ? 225 PHE A CG   1 
ATOM   3538 C CD1  . PHE B 1 225 ? 135.800 106.569 110.376 1.00 38.90  ? 225 PHE A CD1  1 
ATOM   3539 C CD2  . PHE B 1 225 ? 135.346 107.473 108.217 1.00 38.90  ? 225 PHE A CD2  1 
ATOM   3540 C CE1  . PHE B 1 225 ? 136.189 107.816 110.819 1.00 34.19  ? 225 PHE A CE1  1 
ATOM   3541 C CE2  . PHE B 1 225 ? 135.736 108.723 108.656 1.00 36.24  ? 225 PHE A CE2  1 
ATOM   3542 C CZ   . PHE B 1 225 ? 136.159 108.896 109.960 1.00 38.81  ? 225 PHE A CZ   1 
ATOM   3543 N N    . ASP B 1 226 ? 131.902 105.570 107.715 1.00 27.26  ? 226 ASP A N    1 
ATOM   3544 C CA   . ASP B 1 226 ? 130.785 106.466 107.426 1.00 29.15  ? 226 ASP A CA   1 
ATOM   3545 C C    . ASP B 1 226 ? 129.608 106.195 108.352 1.00 35.46  ? 226 ASP A C    1 
ATOM   3546 O O    . ASP B 1 226 ? 128.927 107.128 108.790 1.00 42.41  ? 226 ASP A O    1 
ATOM   3547 C CB   . ASP B 1 226 ? 130.366 106.325 105.962 1.00 33.43  ? 226 ASP A CB   1 
ATOM   3548 C CG   . ASP B 1 226 ? 131.249 107.119 105.021 1.00 41.02  ? 226 ASP A CG   1 
ATOM   3549 O OD1  . ASP B 1 226 ? 132.199 107.769 105.504 1.00 43.08  ? 226 ASP A OD1  1 
ATOM   3550 O OD2  . ASP B 1 226 ? 130.996 107.088 103.800 1.00 41.23  ? 226 ASP A OD2  1 
ATOM   3551 N N    . SER B 1 227 ? 129.349 104.921 108.653 1.00 30.07  ? 227 SER A N    1 
ATOM   3552 C CA   . SER B 1 227 ? 128.277 104.585 109.584 1.00 28.51  ? 227 SER A CA   1 
ATOM   3553 C C    . SER B 1 227 ? 128.568 105.121 110.981 1.00 30.15  ? 227 SER A C    1 
ATOM   3554 O O    . SER B 1 227 ? 127.670 105.651 111.647 1.00 31.72  ? 227 SER A O    1 
ATOM   3555 C CB   . SER B 1 227 ? 128.071 103.072 109.622 1.00 32.03  ? 227 SER A CB   1 
ATOM   3556 O OG   . SER B 1 227 ? 127.728 102.572 108.344 1.00 34.03  ? 227 SER A OG   1 
ATOM   3557 N N    . LEU B 1 228 ? 129.813 104.992 111.446 1.00 29.03  ? 228 LEU A N    1 
ATOM   3558 C CA   . LEU B 1 228 ? 130.164 105.548 112.752 1.00 24.26  ? 228 LEU A CA   1 
ATOM   3559 C C    . LEU B 1 228 ? 130.039 107.069 112.766 1.00 24.69  ? 228 LEU A C    1 
ATOM   3560 O O    . LEU B 1 228 ? 129.572 107.657 113.754 1.00 32.87  ? 228 LEU A O    1 
ATOM   3561 C CB   . LEU B 1 228 ? 131.580 105.121 113.135 1.00 26.40  ? 228 LEU A CB   1 
ATOM   3562 C CG   . LEU B 1 228 ? 131.782 103.647 113.490 1.00 33.95  ? 228 LEU A CG   1 
ATOM   3563 C CD1  . LEU B 1 228 ? 133.262 103.303 113.529 1.00 31.73  ? 228 LEU A CD1  1 
ATOM   3564 C CD2  . LEU B 1 228 ? 131.118 103.306 114.812 1.00 34.55  ? 228 LEU A CD2  1 
ATOM   3565 N N    . TYR B 1 229 ? 130.454 107.727 111.679 1.00 21.06  ? 229 TYR A N    1 
ATOM   3566 C CA   . TYR B 1 229 ? 130.306 109.176 111.575 1.00 22.75  ? 229 TYR A CA   1 
ATOM   3567 C C    . TYR B 1 229 ? 128.834 109.588 111.617 1.00 26.57  ? 229 TYR A C    1 
ATOM   3568 O O    . TYR B 1 229 ? 128.470 110.545 112.314 1.00 23.45  ? 229 TYR A O    1 
ATOM   3569 C CB   . TYR B 1 229 ? 130.984 109.665 110.294 1.00 21.59  ? 229 TYR A CB   1 
ATOM   3570 C CG   . TYR B 1 229 ? 130.772 111.125 109.963 1.00 28.51  ? 229 TYR A CG   1 
ATOM   3571 C CD1  . TYR B 1 229 ? 131.402 112.122 110.693 1.00 23.17  ? 229 TYR A CD1  1 
ATOM   3572 C CD2  . TYR B 1 229 ? 129.967 111.501 108.897 1.00 28.96  ? 229 TYR A CD2  1 
ATOM   3573 C CE1  . TYR B 1 229 ? 131.217 113.454 110.386 1.00 20.53  ? 229 TYR A CE1  1 
ATOM   3574 C CE2  . TYR B 1 229 ? 129.778 112.831 108.582 1.00 30.66  ? 229 TYR A CE2  1 
ATOM   3575 C CZ   . TYR B 1 229 ? 130.405 113.801 109.330 1.00 27.45  ? 229 TYR A CZ   1 
ATOM   3576 O OH   . TYR B 1 229 ? 130.214 115.126 109.013 1.00 28.61  ? 229 TYR A OH   1 
ATOM   3577 N N    . PHE B 1 230 ? 127.979 108.864 110.892 1.00 23.09  ? 230 PHE A N    1 
ATOM   3578 C CA   . PHE B 1 230 ? 126.546 109.148 110.924 1.00 17.82  ? 230 PHE A CA   1 
ATOM   3579 C C    . PHE B 1 230 ? 125.976 108.943 112.319 1.00 23.76  ? 230 PHE A C    1 
ATOM   3580 O O    . PHE B 1 230 ? 125.146 109.735 112.781 1.00 25.64  ? 230 PHE A O    1 
ATOM   3581 C CB   . PHE B 1 230 ? 125.810 108.264 109.915 1.00 23.75  ? 230 PHE A CB   1 
ATOM   3582 C CG   . PHE B 1 230 ? 124.327 108.187 110.144 1.00 32.73  ? 230 PHE A CG   1 
ATOM   3583 C CD1  . PHE B 1 230 ? 123.497 109.231 109.772 1.00 27.70  ? 230 PHE A CD1  1 
ATOM   3584 C CD2  . PHE B 1 230 ? 123.760 107.071 110.743 1.00 28.16  ? 230 PHE A CD2  1 
ATOM   3585 C CE1  . PHE B 1 230 ? 122.135 109.165 109.989 1.00 23.49  ? 230 PHE A CE1  1 
ATOM   3586 C CE2  . PHE B 1 230 ? 122.398 106.999 110.963 1.00 20.64  ? 230 PHE A CE2  1 
ATOM   3587 C CZ   . PHE B 1 230 ? 121.585 108.046 110.586 1.00 21.91  ? 230 PHE A CZ   1 
ATOM   3588 N N    . CYS B 1 231 ? 126.400 107.875 112.999 1.00 30.14  ? 231 CYS A N    1 
ATOM   3589 C CA   . CYS B 1 231 ? 125.920 107.617 114.352 1.00 18.17  ? 231 CYS A CA   1 
ATOM   3590 C C    . CYS B 1 231 ? 126.296 108.756 115.289 1.00 23.12  ? 231 CYS A C    1 
ATOM   3591 O O    . CYS B 1 231 ? 125.468 109.211 116.086 1.00 32.03  ? 231 CYS A O    1 
ATOM   3592 C CB   . CYS B 1 231 ? 126.471 106.287 114.867 1.00 14.22  ? 231 CYS A CB   1 
ATOM   3593 S SG   . CYS B 1 231 ? 125.709 104.827 114.122 1.00 39.87  ? 231 CYS A SG   1 
ATOM   3594 N N    . PHE B 1 232 ? 127.539 109.236 115.203 1.00 24.39  ? 232 PHE A N    1 
ATOM   3595 C CA   . PHE B 1 232 ? 127.945 110.346 116.062 1.00 20.31  ? 232 PHE A CA   1 
ATOM   3596 C C    . PHE B 1 232 ? 127.162 111.612 115.741 1.00 20.36  ? 232 PHE A C    1 
ATOM   3597 O O    . PHE B 1 232 ? 126.741 112.335 116.650 1.00 26.81  ? 232 PHE A O    1 
ATOM   3598 C CB   . PHE B 1 232 ? 129.445 110.613 115.941 1.00 20.42  ? 232 PHE A CB   1 
ATOM   3599 C CG   . PHE B 1 232 ? 129.909 111.787 116.757 1.00 26.85  ? 232 PHE A CG   1 
ATOM   3600 C CD1  . PHE B 1 232 ? 130.098 111.668 118.122 1.00 27.07  ? 232 PHE A CD1  1 
ATOM   3601 C CD2  . PHE B 1 232 ? 130.123 113.022 116.162 1.00 24.84  ? 232 PHE A CD2  1 
ATOM   3602 C CE1  . PHE B 1 232 ? 130.506 112.748 118.879 1.00 22.93  ? 232 PHE A CE1  1 
ATOM   3603 C CE2  . PHE B 1 232 ? 130.532 114.107 116.914 1.00 23.96  ? 232 PHE A CE2  1 
ATOM   3604 C CZ   . PHE B 1 232 ? 130.723 113.969 118.271 1.00 24.20  ? 232 PHE A CZ   1 
ATOM   3605 N N    . VAL B 1 233 ? 126.955 111.902 114.453 1.00 26.34  ? 233 VAL A N    1 
ATOM   3606 C CA   . VAL B 1 233 ? 126.275 113.140 114.083 1.00 21.94  ? 233 VAL A CA   1 
ATOM   3607 C C    . VAL B 1 233 ? 124.813 113.105 114.518 1.00 24.37  ? 233 VAL A C    1 
ATOM   3608 O O    . VAL B 1 233 ? 124.266 114.110 114.984 1.00 21.63  ? 233 VAL A O    1 
ATOM   3609 C CB   . VAL B 1 233 ? 126.415 113.404 112.572 1.00 22.41  ? 233 VAL A CB   1 
ATOM   3610 C CG1  . VAL B 1 233 ? 125.539 114.574 112.149 1.00 14.63  ? 233 VAL A CG1  1 
ATOM   3611 C CG2  . VAL B 1 233 ? 127.864 113.685 112.219 1.00 22.49  ? 233 VAL A CG2  1 
ATOM   3612 N N    . ALA B 1 234 ? 124.156 111.949 114.380 1.00 27.97  ? 234 ALA A N    1 
ATOM   3613 C CA   . ALA B 1 234 ? 122.747 111.851 114.761 1.00 17.68  ? 234 ALA A CA   1 
ATOM   3614 C C    . ALA B 1 234 ? 122.570 111.815 116.274 1.00 24.06  ? 234 ALA A C    1 
ATOM   3615 O O    . ALA B 1 234 ? 121.655 112.452 116.806 1.00 32.70  ? 234 ALA A O    1 
ATOM   3616 C CB   . ALA B 1 234 ? 122.118 110.617 114.118 1.00 17.69  ? 234 ALA A CB   1 
ATOM   3617 N N    . PHE B 1 235 ? 123.431 111.081 116.982 1.00 27.60  ? 235 PHE A N    1 
ATOM   3618 C CA   . PHE B 1 235 ? 123.244 110.896 118.419 1.00 16.60  ? 235 PHE A CA   1 
ATOM   3619 C C    . PHE B 1 235 ? 123.474 112.185 119.199 1.00 22.50  ? 235 PHE A C    1 
ATOM   3620 O O    . PHE B 1 235 ? 122.819 112.410 120.222 1.00 25.63  ? 235 PHE A O    1 
ATOM   3621 C CB   . PHE B 1 235 ? 124.162 109.792 118.943 1.00 13.60  ? 235 PHE A CB   1 
ATOM   3622 C CG   . PHE B 1 235 ? 123.800 108.413 118.464 1.00 23.94  ? 235 PHE A CG   1 
ATOM   3623 C CD1  . PHE B 1 235 ? 122.627 108.188 117.760 1.00 25.16  ? 235 PHE A CD1  1 
ATOM   3624 C CD2  . PHE B 1 235 ? 124.634 107.337 118.723 1.00 24.18  ? 235 PHE A CD2  1 
ATOM   3625 C CE1  . PHE B 1 235 ? 122.299 106.923 117.321 1.00 22.28  ? 235 PHE A CE1  1 
ATOM   3626 C CE2  . PHE B 1 235 ? 124.309 106.068 118.287 1.00 16.56  ? 235 PHE A CE2  1 
ATOM   3627 C CZ   . PHE B 1 235 ? 123.141 105.860 117.584 1.00 20.61  ? 235 PHE A CZ   1 
ATOM   3628 N N    . SER B 1 236 ? 124.397 113.030 118.746 1.00 22.75  ? 236 SER A N    1 
ATOM   3629 C CA   . SER B 1 236 ? 124.680 114.297 119.413 1.00 22.34  ? 236 SER A CA   1 
ATOM   3630 C C    . SER B 1 236 ? 123.658 115.383 119.102 1.00 29.26  ? 236 SER A C    1 
ATOM   3631 O O    . SER B 1 236 ? 123.808 116.502 119.603 1.00 28.26  ? 236 SER A O    1 
ATOM   3632 C CB   . SER B 1 236 ? 126.079 114.784 119.030 1.00 21.75  ? 236 SER A CB   1 
ATOM   3633 O OG   . SER B 1 236 ? 126.192 114.957 117.629 1.00 20.74  ? 236 SER A OG   1 
ATOM   3634 N N    . THR B 1 237 ? 122.633 115.078 118.305 1.00 28.41  ? 237 THR A N    1 
ATOM   3635 C CA   . THR B 1 237 ? 121.583 116.027 117.911 1.00 22.57  ? 237 THR A CA   1 
ATOM   3636 C C    . THR B 1 237 ? 122.146 117.227 117.154 1.00 27.41  ? 237 THR A C    1 
ATOM   3637 O O    . THR B 1 237 ? 121.574 118.316 117.184 1.00 40.49  ? 237 THR A O    1 
ATOM   3638 C CB   . THR B 1 237 ? 120.750 116.504 119.109 1.00 27.75  ? 237 THR A CB   1 
ATOM   3639 O OG1  . THR B 1 237 ? 121.598 117.116 120.089 1.00 34.78  ? 237 THR A OG1  1 
ATOM   3640 C CG2  . THR B 1 237 ? 120.016 115.335 119.748 1.00 23.57  ? 237 THR A CG2  1 
ATOM   3641 N N    . ILE B 1 238 ? 123.265 117.032 116.455 1.00 20.21  ? 238 ILE A N    1 
ATOM   3642 C CA   . ILE B 1 238 ? 123.760 118.055 115.540 1.00 17.78  ? 238 ILE A CA   1 
ATOM   3643 C C    . ILE B 1 238 ? 122.961 118.031 114.242 1.00 27.46  ? 238 ILE A C    1 
ATOM   3644 O O    . ILE B 1 238 ? 122.421 119.053 113.809 1.00 40.08  ? 238 ILE A O    1 
ATOM   3645 C CB   . ILE B 1 238 ? 125.268 117.866 115.288 1.00 20.38  ? 238 ILE A CB   1 
ATOM   3646 C CG1  . ILE B 1 238 ? 126.058 118.196 116.557 1.00 24.67  ? 238 ILE A CG1  1 
ATOM   3647 C CG2  . ILE B 1 238 ? 125.730 118.732 114.128 1.00 11.48  ? 238 ILE A CG2  1 
ATOM   3648 C CD1  . ILE B 1 238 ? 127.558 118.100 116.390 1.00 15.44  ? 238 ILE A CD1  1 
ATOM   3649 N N    . GLY B 1 239 ? 122.883 116.866 113.602 1.00 21.52  ? 239 GLY A N    1 
ATOM   3650 C CA   . GLY B 1 239 ? 122.024 116.672 112.448 1.00 8.65   ? 239 GLY A CA   1 
ATOM   3651 C C    . GLY B 1 239 ? 122.346 117.477 111.206 1.00 23.79  ? 239 GLY A C    1 
ATOM   3652 O O    . GLY B 1 239 ? 121.486 118.209 110.705 1.00 37.54  ? 239 GLY A O    1 
ATOM   3653 N N    . PHE B 1 240 ? 123.581 117.361 110.711 1.00 23.72  ? 240 PHE A N    1 
ATOM   3654 C CA   . PHE B 1 240 ? 123.968 118.038 109.475 1.00 15.94  ? 240 PHE A CA   1 
ATOM   3655 C C    . PHE B 1 240 ? 122.980 117.755 108.349 1.00 26.33  ? 240 PHE A C    1 
ATOM   3656 O O    . PHE B 1 240 ? 122.580 118.667 107.614 1.00 35.21  ? 240 PHE A O    1 
ATOM   3657 C CB   . PHE B 1 240 ? 125.381 117.620 109.062 1.00 20.43  ? 240 PHE A CB   1 
ATOM   3658 C CG   . PHE B 1 240 ? 126.468 118.217 109.909 1.00 20.94  ? 240 PHE A CG   1 
ATOM   3659 C CD1  . PHE B 1 240 ? 126.341 119.495 110.420 1.00 24.05  ? 240 PHE A CD1  1 
ATOM   3660 C CD2  . PHE B 1 240 ? 127.623 117.504 110.179 1.00 18.39  ? 240 PHE A CD2  1 
ATOM   3661 C CE1  . PHE B 1 240 ? 127.342 120.052 111.193 1.00 25.82  ? 240 PHE A CE1  1 
ATOM   3662 C CE2  . PHE B 1 240 ? 128.628 118.052 110.956 1.00 22.78  ? 240 PHE A CE2  1 
ATOM   3663 C CZ   . PHE B 1 240 ? 128.487 119.329 111.461 1.00 21.86  ? 240 PHE A CZ   1 
ATOM   3664 N N    . GLY B 1 241 ? 122.577 116.496 108.190 1.00 27.83  ? 241 GLY A N    1 
ATOM   3665 C CA   . GLY B 1 241 ? 121.663 116.116 107.133 1.00 23.83  ? 241 GLY A CA   1 
ATOM   3666 C C    . GLY B 1 241 ? 122.308 115.544 105.890 1.00 31.45  ? 241 GLY A C    1 
ATOM   3667 O O    . GLY B 1 241 ? 121.584 115.157 104.963 1.00 37.78  ? 241 GLY A O    1 
ATOM   3668 N N    . ASP B 1 242 ? 123.640 115.499 105.830 1.00 30.61  ? 242 ASP A N    1 
ATOM   3669 C CA   . ASP B 1 242 ? 124.316 114.905 104.680 1.00 26.36  ? 242 ASP A CA   1 
ATOM   3670 C C    . ASP B 1 242 ? 124.040 113.409 104.567 1.00 34.81  ? 242 ASP A C    1 
ATOM   3671 O O    . ASP B 1 242 ? 123.885 112.885 103.458 1.00 39.76  ? 242 ASP A O    1 
ATOM   3672 C CB   . ASP B 1 242 ? 125.818 115.179 104.758 1.00 26.00  ? 242 ASP A CB   1 
ATOM   3673 C CG   . ASP B 1 242 ? 126.390 114.927 106.141 1.00 42.09  ? 242 ASP A CG   1 
ATOM   3674 O OD1  . ASP B 1 242 ? 125.606 114.886 107.113 1.00 44.84  ? 242 ASP A OD1  1 
ATOM   3675 O OD2  . ASP B 1 242 ? 127.620 114.767 106.258 1.00 43.01  ? 242 ASP A OD2  1 
ATOM   3676 N N    . LEU B 1 243 ? 123.998 112.699 105.692 1.00 33.83  ? 243 LEU A N    1 
ATOM   3677 C CA   . LEU B 1 243 ? 123.657 111.279 105.723 1.00 28.87  ? 243 LEU A CA   1 
ATOM   3678 C C    . LEU B 1 243 ? 122.384 111.075 106.531 1.00 31.58  ? 243 LEU A C    1 
ATOM   3679 O O    . LEU B 1 243 ? 122.345 111.407 107.721 1.00 39.08  ? 243 LEU A O    1 
ATOM   3680 C CB   . LEU B 1 243 ? 124.796 110.443 106.311 1.00 30.39  ? 243 LEU A CB   1 
ATOM   3681 C CG   . LEU B 1 243 ? 126.084 110.332 105.490 1.00 32.80  ? 243 LEU A CG   1 
ATOM   3682 C CD1  . LEU B 1 243 ? 127.137 109.556 106.258 1.00 31.40  ? 243 LEU A CD1  1 
ATOM   3683 C CD2  . LEU B 1 243 ? 125.808 109.675 104.150 1.00 31.48  ? 243 LEU A CD2  1 
ATOM   3684 N N    . VAL B 1 244 ? 121.345 110.546 105.886 1.00 29.08  ? 244 VAL A N    1 
ATOM   3685 C CA   . VAL B 1 244 ? 120.092 110.198 106.551 1.00 27.96  ? 244 VAL A CA   1 
ATOM   3686 C C    . VAL B 1 244 ? 119.710 108.780 106.143 1.00 30.36  ? 244 VAL A C    1 
ATOM   3687 O O    . VAL B 1 244 ? 119.773 108.432 104.957 1.00 33.99  ? 244 VAL A O    1 
ATOM   3688 C CB   . VAL B 1 244 ? 118.961 111.186 106.201 1.00 27.18  ? 244 VAL A CB   1 
ATOM   3689 C CG1  . VAL B 1 244 ? 117.693 110.845 106.968 1.00 27.95  ? 244 VAL A CG1  1 
ATOM   3690 C CG2  . VAL B 1 244 ? 119.387 112.618 106.491 1.00 29.30  ? 244 VAL A CG2  1 
ATOM   3691 N N    . SER B 1 245 ? 119.326 107.969 107.119 1.00 26.08  ? 245 SER A N    1 
ATOM   3692 C CA   . SER B 1 245 ? 119.003 106.562 106.920 1.00 25.97  ? 245 SER A CA   1 
ATOM   3693 C C    . SER B 1 245 ? 117.510 106.346 106.668 1.00 33.89  ? 245 SER A C    1 
ATOM   3694 O O    . SER B 1 245 ? 116.666 107.186 106.992 1.00 35.57  ? 245 SER A O    1 
ATOM   3695 C CB   . SER B 1 245 ? 119.445 105.736 108.129 1.00 24.98  ? 245 SER A CB   1 
ATOM   3696 O OG   . SER B 1 245 ? 118.753 106.134 109.299 1.00 32.22  ? 245 SER A OG   1 
ATOM   3697 N N    . SER B 1 246 ? 117.200 105.192 106.064 1.00 33.00  ? 246 SER A N    1 
ATOM   3698 C CA   . SER B 1 246 ? 115.827 104.732 105.835 1.00 30.00  ? 246 SER A CA   1 
ATOM   3699 C C    . SER B 1 246 ? 115.048 105.645 104.887 1.00 31.96  ? 246 SER A C    1 
ATOM   3700 O O    . SER B 1 246 ? 113.945 106.097 105.194 1.00 36.70  ? 246 SER A O    1 
ATOM   3701 C CB   . SER B 1 246 ? 115.085 104.566 107.165 1.00 32.04  ? 246 SER A CB   1 
ATOM   3702 O OG   . SER B 1 246 ? 113.986 103.686 107.033 1.00 42.03  ? 246 SER A OG   1 
ATOM   3703 N N    . GLN B 1 247 ? 115.626 105.914 103.715 1.00 40.80  ? 247 GLN A N    1 
ATOM   3704 C CA   . GLN B 1 247 ? 114.993 106.790 102.730 1.00 33.07  ? 247 GLN A CA   1 
ATOM   3705 C C    . GLN B 1 247 ? 115.150 106.241 101.315 1.00 33.00  ? 247 GLN A C    1 
ATOM   3706 O O    . GLN B 1 247 ? 115.467 106.986 100.383 1.00 44.58  ? 247 GLN A O    1 
ATOM   3707 C CB   . GLN B 1 247 ? 115.547 108.212 102.804 1.00 29.81  ? 247 GLN A CB   1 
ATOM   3708 C CG   . GLN B 1 247 ? 115.692 108.782 104.207 1.00 28.46  ? 247 GLN A CG   1 
ATOM   3709 C CD   . GLN B 1 247 ? 114.804 109.983 104.430 1.00 38.62  ? 247 GLN A CD   1 
ATOM   3710 O OE1  . GLN B 1 247 ? 114.918 110.990 103.735 1.00 50.00  ? 247 GLN A OE1  1 
ATOM   3711 N NE2  . GLN B 1 247 ? 113.908 109.883 105.405 1.00 40.20  ? 247 GLN A NE2  1 
ATOM   3712 N N    . ASN B 1 248 ? 114.921 104.940 101.123 1.00 33.43  ? 248 ASN A N    1 
ATOM   3713 C CA   . ASN B 1 248 ? 115.207 104.308 99.837  1.00 34.19  ? 248 ASN A CA   1 
ATOM   3714 C C    . ASN B 1 248 ? 113.994 103.599 99.238  1.00 41.86  ? 248 ASN A C    1 
ATOM   3715 O O    . ASN B 1 248 ? 114.145 102.562 98.583  1.00 53.08  ? 248 ASN A O    1 
ATOM   3716 C CB   . ASN B 1 248 ? 116.372 103.326 99.966  1.00 38.10  ? 248 ASN A CB   1 
ATOM   3717 C CG   . ASN B 1 248 ? 117.705 103.959 99.635  1.00 42.87  ? 248 ASN A CG   1 
ATOM   3718 O OD1  . ASN B 1 248 ? 117.769 104.985 98.958  1.00 46.08  ? 248 ASN A OD1  1 
ATOM   3719 N ND2  . ASN B 1 248 ? 118.782 103.348 100.112 1.00 44.20  ? 248 ASN A ND2  1 
ATOM   3720 N N    . ALA B 1 249 ? 112.792 104.135 99.450  1.00 38.71  ? 249 ALA A N    1 
ATOM   3721 C CA   . ALA B 1 249 ? 111.543 103.596 98.894  1.00 40.62  ? 249 ALA A CA   1 
ATOM   3722 C C    . ALA B 1 249 ? 111.389 102.143 99.337  1.00 47.01  ? 249 ALA A C    1 
ATOM   3723 O O    . ALA B 1 249 ? 111.275 101.899 100.551 1.00 53.26  ? 249 ALA A O    1 
ATOM   3724 C CB   . ALA B 1 249 ? 111.536 103.833 97.384  1.00 35.81  ? 249 ALA A CB   1 
ATOM   3725 N N    . HIS B 1 250 ? 111.359 101.168 98.425  1.00 45.82  ? 250 HIS A N    1 
ATOM   3726 C CA   . HIS B 1 250 ? 111.322 99.766  98.817  1.00 47.17  ? 250 HIS A CA   1 
ATOM   3727 C C    . HIS B 1 250 ? 112.568 99.430  99.625  1.00 43.96  ? 250 HIS A C    1 
ATOM   3728 O O    . HIS B 1 250 ? 113.692 99.598  99.149  1.00 39.55  ? 250 HIS A O    1 
ATOM   3729 C CB   . HIS B 1 250 ? 111.219 98.874  97.578  1.00 46.47  ? 250 HIS A CB   1 
ATOM   3730 C CG   . HIS B 1 250 ? 111.442 97.420  97.858  1.00 49.67  ? 250 HIS A CG   1 
ATOM   3731 N ND1  . HIS B 1 250 ? 112.486 96.707  97.309  1.00 50.90  ? 250 HIS A ND1  1 
ATOM   3732 C CD2  . HIS B 1 250 ? 110.754 96.546  98.632  1.00 46.54  ? 250 HIS A CD2  1 
ATOM   3733 C CE1  . HIS B 1 250 ? 112.430 95.454  97.731  1.00 51.73  ? 250 HIS A CE1  1 
ATOM   3734 N NE2  . HIS B 1 250 ? 111.389 95.333  98.535  1.00 50.61  ? 250 HIS A NE2  1 
ATOM   3735 N N    . TYR B 1 251 ? 112.362 98.953  100.850 1.00 44.15  ? 251 TYR A N    1 
ATOM   3736 C CA   . TYR B 1 251 ? 113.453 98.658  101.769 1.00 40.74  ? 251 TYR A CA   1 
ATOM   3737 C C    . TYR B 1 251 ? 113.346 97.220  102.277 1.00 40.58  ? 251 TYR A C    1 
ATOM   3738 O O    . TYR B 1 251 ? 113.281 96.987  103.482 1.00 42.79  ? 251 TYR A O    1 
ATOM   3739 C CB   . TYR B 1 251 ? 113.445 99.649  102.931 1.00 45.51  ? 251 TYR A CB   1 
ATOM   3740 C CG   . TYR B 1 251 ? 114.748 100.374 103.129 1.00 40.79  ? 251 TYR A CG   1 
ATOM   3741 C CD1  . TYR B 1 251 ? 115.928 99.680  103.346 1.00 32.54  ? 251 TYR A CD1  1 
ATOM   3742 C CD2  . TYR B 1 251 ? 114.798 101.760 103.098 1.00 39.77  ? 251 TYR A CD2  1 
ATOM   3743 C CE1  . TYR B 1 251 ? 117.120 100.349 103.527 1.00 38.43  ? 251 TYR A CE1  1 
ATOM   3744 C CE2  . TYR B 1 251 ? 115.983 102.432 103.279 1.00 31.39  ? 251 TYR A CE2  1 
ATOM   3745 C CZ   . TYR B 1 251 ? 117.140 101.724 103.495 1.00 37.84  ? 251 TYR A CZ   1 
ATOM   3746 O OH   . TYR B 1 251 ? 118.323 102.398 103.673 1.00 44.38  ? 251 TYR A OH   1 
ATOM   3747 N N    . GLU B 1 252 ? 113.386 96.250  101.353 1.00 48.18  ? 252 GLU A N    1 
ATOM   3748 C CA   . GLU B 1 252 ? 113.298 94.835  101.717 1.00 48.25  ? 252 GLU A CA   1 
ATOM   3749 C C    . GLU B 1 252 ? 112.170 94.631  102.722 1.00 53.60  ? 252 GLU A C    1 
ATOM   3750 O O    . GLU B 1 252 ? 111.021 94.985  102.441 1.00 57.31  ? 252 GLU A O    1 
ATOM   3751 C CB   . GLU B 1 252 ? 114.631 94.341  102.287 1.00 46.97  ? 252 GLU A CB   1 
ATOM   3752 C CG   . GLU B 1 252 ? 114.922 92.853  102.097 1.00 50.57  ? 252 GLU A CG   1 
ATOM   3753 C CD   . GLU B 1 252 ? 114.433 92.310  100.765 1.00 55.80  ? 252 GLU A CD   1 
ATOM   3754 O OE1  . GLU B 1 252 ? 113.269 91.868  100.688 1.00 53.56  ? 252 GLU A OE1  1 
ATOM   3755 O OE2  . GLU B 1 252 ? 115.218 92.326  99.797  1.00 56.44  ? 252 GLU A OE2  1 
ATOM   3756 N N    . SER B 1 253 ? 112.479 94.055  103.887 1.00 49.52  ? 253 SER A N    1 
ATOM   3757 C CA   . SER B 1 253 ? 111.432 93.719  104.852 1.00 46.24  ? 253 SER A CA   1 
ATOM   3758 C C    . SER B 1 253 ? 110.671 94.973  105.271 1.00 50.72  ? 253 SER A C    1 
ATOM   3759 O O    . SER B 1 253 ? 109.436 94.997  105.255 1.00 52.29  ? 253 SER A O    1 
ATOM   3760 C CB   . SER B 1 253 ? 112.039 93.018  106.065 1.00 43.70  ? 253 SER A CB   1 
ATOM   3761 O OG   . SER B 1 253 ? 111.050 92.748  107.041 1.00 52.38  ? 253 SER A OG   1 
ATOM   3762 N N    . GLN B 1 254 ? 111.398 96.012  105.686 1.00 45.69  ? 254 GLN A N    1 
ATOM   3763 C CA   . GLN B 1 254 ? 110.860 97.360  105.852 1.00 43.15  ? 254 GLN A CA   1 
ATOM   3764 C C    . GLN B 1 254 ? 109.869 97.493  107.006 1.00 45.88  ? 254 GLN A C    1 
ATOM   3765 O O    . GLN B 1 254 ? 109.434 98.605  107.323 1.00 49.70  ? 254 GLN A O    1 
ATOM   3766 C CB   . GLN B 1 254 ? 110.207 97.822  104.543 1.00 37.82  ? 254 GLN A CB   1 
ATOM   3767 C CG   . GLN B 1 254 ? 110.163 99.326  104.352 1.00 43.08  ? 254 GLN A CG   1 
ATOM   3768 C CD   . GLN B 1 254 ? 109.322 99.733  103.162 1.00 46.60  ? 254 GLN A CD   1 
ATOM   3769 O OE1  . GLN B 1 254 ? 108.466 98.976  102.705 1.00 51.50  ? 254 GLN A OE1  1 
ATOM   3770 N NE2  . GLN B 1 254 ? 109.574 100.923 102.637 1.00 46.05  ? 254 GLN A NE2  1 
ATOM   3771 N N    . GLY B 1 255 ? 109.513 96.388  107.649 1.00 44.98  ? 255 GLY A N    1 
ATOM   3772 C CA   . GLY B 1 255 ? 108.658 96.473  108.815 1.00 38.65  ? 255 GLY A CA   1 
ATOM   3773 C C    . GLY B 1 255 ? 109.465 96.475  110.098 1.00 41.63  ? 255 GLY A C    1 
ATOM   3774 O O    . GLY B 1 255 ? 109.264 97.321  110.970 1.00 46.76  ? 255 GLY A O    1 
ATOM   3775 N N    . LEU B 1 256 ? 110.387 95.519  110.214 1.00 38.02  ? 256 LEU A N    1 
ATOM   3776 C CA   . LEU B 1 256 ? 111.298 95.468  111.353 1.00 34.69  ? 256 LEU A CA   1 
ATOM   3777 C C    . LEU B 1 256 ? 112.412 96.502  111.249 1.00 33.09  ? 256 LEU A C    1 
ATOM   3778 O O    . LEU B 1 256 ? 112.936 96.947  112.278 1.00 40.37  ? 256 LEU A O    1 
ATOM   3779 C CB   . LEU B 1 256 ? 111.901 94.067  111.492 1.00 32.75  ? 256 LEU A CB   1 
ATOM   3780 C CG   . LEU B 1 256 ? 111.066 92.881  111.990 1.00 37.17  ? 256 LEU A CG   1 
ATOM   3781 C CD1  . LEU B 1 256 ? 109.829 92.605  111.140 1.00 37.71  ? 256 LEU A CD1  1 
ATOM   3782 C CD2  . LEU B 1 256 ? 111.934 91.637  112.081 1.00 40.17  ? 256 LEU A CD2  1 
ATOM   3783 N N    . TYR B 1 257 ? 112.784 96.888  110.026 1.00 26.96  ? 257 TYR A N    1 
ATOM   3784 C CA   . TYR B 1 257 ? 113.904 97.806  109.827 1.00 26.36  ? 257 TYR A CA   1 
ATOM   3785 C C    . TYR B 1 257 ? 113.616 99.190  110.403 1.00 34.25  ? 257 TYR A C    1 
ATOM   3786 O O    . TYR B 1 257 ? 114.475 99.782  111.069 1.00 34.50  ? 257 TYR A O    1 
ATOM   3787 C CB   . TYR B 1 257 ? 114.221 97.890  108.332 1.00 26.42  ? 257 TYR A CB   1 
ATOM   3788 C CG   . TYR B 1 257 ? 115.453 98.693  107.979 1.00 33.49  ? 257 TYR A CG   1 
ATOM   3789 C CD1  . TYR B 1 257 ? 116.724 98.214  108.267 1.00 35.95  ? 257 TYR A CD1  1 
ATOM   3790 C CD2  . TYR B 1 257 ? 115.343 99.920  107.339 1.00 30.35  ? 257 TYR A CD2  1 
ATOM   3791 C CE1  . TYR B 1 257 ? 117.850 98.943  107.943 1.00 32.94  ? 257 TYR A CE1  1 
ATOM   3792 C CE2  . TYR B 1 257 ? 116.463 100.655 107.012 1.00 28.37  ? 257 TYR A CE2  1 
ATOM   3793 C CZ   . TYR B 1 257 ? 117.712 100.162 107.315 1.00 32.18  ? 257 TYR A CZ   1 
ATOM   3794 O OH   . TYR B 1 257 ? 118.830 100.890 106.987 1.00 36.77  ? 257 TYR A OH   1 
ATOM   3795 N N    . ARG B 1 258 ? 112.406 99.708  110.186 1.00 32.51  ? 258 ARG A N    1 
ATOM   3796 C CA   . ARG B 1 258 ? 112.053 101.021 110.725 1.00 25.79  ? 258 ARG A CA   1 
ATOM   3797 C C    . ARG B 1 258 ? 112.004 100.992 112.248 1.00 30.22  ? 258 ARG A C    1 
ATOM   3798 O O    . ARG B 1 258 ? 112.464 101.934 112.909 1.00 37.02  ? 258 ARG A O    1 
ATOM   3799 C CB   . ARG B 1 258 ? 110.714 101.482 110.151 1.00 29.07  ? 258 ARG A CB   1 
ATOM   3800 C CG   . ARG B 1 258 ? 110.614 101.372 108.635 1.00 31.09  ? 258 ARG A CG   1 
ATOM   3801 C CD   . ARG B 1 258 ? 109.379 102.081 108.101 1.00 31.56  ? 258 ARG A CD   1 
ATOM   3802 N NE   . ARG B 1 258 ? 109.540 102.504 106.714 1.00 34.08  ? 258 ARG A NE   1 
ATOM   3803 C CZ   . ARG B 1 258 ? 108.534 102.741 105.882 1.00 33.62  ? 258 ARG A CZ   1 
ATOM   3804 N NH1  . ARG B 1 258 ? 107.274 102.587 106.257 1.00 38.87  ? 258 ARG A NH1  1 
ATOM   3805 N NH2  . ARG B 1 258 ? 108.796 103.135 104.639 1.00 30.99  ? 258 ARG A NH2  1 
ATOM   3806 N N    . PHE B 1 259 ? 111.462 99.916  112.816 1.00 32.36  ? 259 PHE A N    1 
ATOM   3807 C CA   . PHE B 1 259 ? 111.411 99.767  114.267 1.00 30.18  ? 259 PHE A CA   1 
ATOM   3808 C C    . PHE B 1 259 ? 112.815 99.718  114.865 1.00 31.60  ? 259 PHE A C    1 
ATOM   3809 O O    . PHE B 1 259 ? 113.089 100.366 115.886 1.00 35.23  ? 259 PHE A O    1 
ATOM   3810 C CB   . PHE B 1 259 ? 110.612 98.507  114.605 1.00 24.55  ? 259 PHE A CB   1 
ATOM   3811 C CG   . PHE B 1 259 ? 110.654 98.119  116.051 1.00 33.96  ? 259 PHE A CG   1 
ATOM   3812 C CD1  . PHE B 1 259 ? 109.985 98.866  117.002 1.00 34.65  ? 259 PHE A CD1  1 
ATOM   3813 C CD2  . PHE B 1 259 ? 111.347 96.991  116.458 1.00 32.11  ? 259 PHE A CD2  1 
ATOM   3814 C CE1  . PHE B 1 259 ? 110.018 98.510  118.333 1.00 33.02  ? 259 PHE A CE1  1 
ATOM   3815 C CE2  . PHE B 1 259 ? 111.383 96.628  117.786 1.00 32.07  ? 259 PHE A CE2  1 
ATOM   3816 C CZ   . PHE B 1 259 ? 110.719 97.388  118.725 1.00 31.12  ? 259 PHE A CZ   1 
ATOM   3817 N N    . ALA B 1 260 ? 113.720 98.969  114.230 1.00 30.09  ? 260 ALA A N    1 
ATOM   3818 C CA   . ALA B 1 260 ? 115.097 98.899  114.709 1.00 28.16  ? 260 ALA A CA   1 
ATOM   3819 C C    . ALA B 1 260 ? 115.796 100.251 114.610 1.00 27.85  ? 260 ALA A C    1 
ATOM   3820 O O    . ALA B 1 260 ? 116.543 100.641 115.519 1.00 38.36  ? 260 ALA A O    1 
ATOM   3821 C CB   . ALA B 1 260 ? 115.869 97.837  113.929 1.00 28.89  ? 260 ALA A CB   1 
ATOM   3822 N N    . ASN B 1 261 ? 115.566 100.983 113.517 1.00 30.11  ? 261 ASN A N    1 
ATOM   3823 C CA   . ASN B 1 261 ? 116.140 102.320 113.374 1.00 33.95  ? 261 ASN A CA   1 
ATOM   3824 C C    . ASN B 1 261 ? 115.655 103.246 114.485 1.00 29.24  ? 261 ASN A C    1 
ATOM   3825 O O    . ASN B 1 261 ? 116.450 103.974 115.100 1.00 32.16  ? 261 ASN A O    1 
ATOM   3826 C CB   . ASN B 1 261 ? 115.784 102.888 111.999 1.00 29.50  ? 261 ASN A CB   1 
ATOM   3827 C CG   . ASN B 1 261 ? 116.601 104.115 111.644 1.00 32.98  ? 261 ASN A CG   1 
ATOM   3828 O OD1  . ASN B 1 261 ? 117.710 104.302 112.142 1.00 41.69  ? 261 ASN A OD1  1 
ATOM   3829 N ND2  . ASN B 1 261 ? 116.052 104.960 110.781 1.00 29.28  ? 261 ASN A ND2  1 
ATOM   3830 N N    . PHE B 1 262 ? 114.349 103.214 114.763 1.00 24.71  ? 262 PHE A N    1 
ATOM   3831 C CA   . PHE B 1 262 ? 113.775 104.036 115.825 1.00 30.73  ? 262 PHE A CA   1 
ATOM   3832 C C    . PHE B 1 262 ? 114.421 103.714 117.170 1.00 35.79  ? 262 PHE A C    1 
ATOM   3833 O O    . PHE B 1 262 ? 114.847 104.618 117.904 1.00 32.00  ? 262 PHE A O    1 
ATOM   3834 C CB   . PHE B 1 262 ? 112.264 103.799 115.872 1.00 27.77  ? 262 PHE A CB   1 
ATOM   3835 C CG   . PHE B 1 262 ? 111.558 104.530 116.976 1.00 34.98  ? 262 PHE A CG   1 
ATOM   3836 C CD1  . PHE B 1 262 ? 111.303 105.887 116.878 1.00 35.51  ? 262 PHE A CD1  1 
ATOM   3837 C CD2  . PHE B 1 262 ? 111.146 103.860 118.115 1.00 34.23  ? 262 PHE A CD2  1 
ATOM   3838 C CE1  . PHE B 1 262 ? 110.652 106.558 117.890 1.00 31.57  ? 262 PHE A CE1  1 
ATOM   3839 C CE2  . PHE B 1 262 ? 110.496 104.528 119.132 1.00 27.99  ? 262 PHE A CE2  1 
ATOM   3840 C CZ   . PHE B 1 262 ? 110.249 105.878 119.020 1.00 26.16  ? 262 PHE A CZ   1 
ATOM   3841 N N    . VAL B 1 263 ? 114.532 102.424 117.491 1.00 38.05  ? 263 VAL A N    1 
ATOM   3842 C CA   . VAL B 1 263 ? 115.083 102.009 118.781 1.00 27.87  ? 263 VAL A CA   1 
ATOM   3843 C C    . VAL B 1 263 ? 116.540 102.447 118.903 1.00 30.00  ? 263 VAL A C    1 
ATOM   3844 O O    . VAL B 1 263 ? 116.961 102.992 119.935 1.00 40.66  ? 263 VAL A O    1 
ATOM   3845 C CB   . VAL B 1 263 ? 114.929 100.488 118.961 1.00 26.28  ? 263 VAL A CB   1 
ATOM   3846 C CG1  . VAL B 1 263 ? 115.767 99.996  120.131 1.00 33.00  ? 263 VAL A CG1  1 
ATOM   3847 C CG2  . VAL B 1 263 ? 113.467 100.121 119.156 1.00 30.87  ? 263 VAL A CG2  1 
ATOM   3848 N N    . PHE B 1 264 ? 117.331 102.208 117.853 1.00 25.77  ? 264 PHE A N    1 
ATOM   3849 C CA   . PHE B 1 264 ? 118.748 102.546 117.897 1.00 22.93  ? 264 PHE A CA   1 
ATOM   3850 C C    . PHE B 1 264 ? 118.957 104.043 118.082 1.00 22.39  ? 264 PHE A C    1 
ATOM   3851 O O    . PHE B 1 264 ? 119.779 104.464 118.909 1.00 30.37  ? 264 PHE A O    1 
ATOM   3852 C CB   . PHE B 1 264 ? 119.442 102.074 116.617 1.00 26.91  ? 264 PHE A CB   1 
ATOM   3853 C CG   . PHE B 1 264 ? 119.828 100.624 116.627 1.00 35.31  ? 264 PHE A CG   1 
ATOM   3854 C CD1  . PHE B 1 264 ? 120.468 100.070 117.724 1.00 31.87  ? 264 PHE A CD1  1 
ATOM   3855 C CD2  . PHE B 1 264 ? 119.570 99.820  115.531 1.00 29.88  ? 264 PHE A CD2  1 
ATOM   3856 C CE1  . PHE B 1 264 ? 120.828 98.737  117.727 1.00 28.76  ? 264 PHE A CE1  1 
ATOM   3857 C CE2  . PHE B 1 264 ? 119.929 98.488  115.529 1.00 28.07  ? 264 PHE A CE2  1 
ATOM   3858 C CZ   . PHE B 1 264 ? 120.560 97.945  116.631 1.00 32.25  ? 264 PHE A CZ   1 
ATOM   3859 N N    . ILE B 1 265 ? 118.210 104.866 117.340 1.00 28.80  ? 265 ILE A N    1 
ATOM   3860 C CA   . ILE B 1 265 ? 118.378 106.312 117.465 1.00 28.64  ? 265 ILE A CA   1 
ATOM   3861 C C    . ILE B 1 265 ? 117.982 106.782 118.860 1.00 29.74  ? 265 ILE A C    1 
ATOM   3862 O O    . ILE B 1 265 ? 118.671 107.613 119.468 1.00 33.06  ? 265 ILE A O    1 
ATOM   3863 C CB   . ILE B 1 265 ? 117.584 107.045 116.365 1.00 30.82  ? 265 ILE A CB   1 
ATOM   3864 C CG1  . ILE B 1 265 ? 118.173 106.730 114.990 1.00 26.83  ? 265 ILE A CG1  1 
ATOM   3865 C CG2  . ILE B 1 265 ? 117.582 108.545 116.609 1.00 31.15  ? 265 ILE A CG2  1 
ATOM   3866 C CD1  . ILE B 1 265 ? 117.558 107.525 113.861 1.00 26.89  ? 265 ILE A CD1  1 
ATOM   3867 N N    . LEU B 1 266 ? 116.885 106.243 119.402 1.00 27.43  ? 266 LEU A N    1 
ATOM   3868 C CA   . LEU B 1 266 ? 116.456 106.642 120.740 1.00 25.15  ? 266 LEU A CA   1 
ATOM   3869 C C    . LEU B 1 266 ? 117.528 106.343 121.786 1.00 28.61  ? 266 LEU A C    1 
ATOM   3870 O O    . LEU B 1 266 ? 117.916 107.223 122.572 1.00 28.14  ? 266 LEU A O    1 
ATOM   3871 C CB   . LEU B 1 266 ? 115.143 105.939 121.089 1.00 26.80  ? 266 LEU A CB   1 
ATOM   3872 C CG   . LEU B 1 266 ? 114.580 106.158 122.493 1.00 26.39  ? 266 LEU A CG   1 
ATOM   3873 C CD1  . LEU B 1 266 ? 114.126 107.593 122.678 1.00 28.53  ? 266 LEU A CD1  1 
ATOM   3874 C CD2  . LEU B 1 266 ? 113.436 105.204 122.751 1.00 22.41  ? 266 LEU A CD2  1 
ATOM   3875 N N    . MET B 1 267 ? 118.034 105.104 121.797 1.00 27.57  ? 267 MET A N    1 
ATOM   3876 C CA   . MET B 1 267 ? 119.042 104.734 122.788 1.00 26.41  ? 267 MET A CA   1 
ATOM   3877 C C    . MET B 1 267 ? 120.323 105.547 122.626 1.00 33.27  ? 267 MET A C    1 
ATOM   3878 O O    . MET B 1 267 ? 120.910 105.995 123.623 1.00 43.69  ? 267 MET A O    1 
ATOM   3879 C CB   . MET B 1 267 ? 119.337 103.237 122.713 1.00 26.68  ? 267 MET A CB   1 
ATOM   3880 C CG   . MET B 1 267 ? 118.099 102.358 122.716 1.00 32.44  ? 267 MET A CG   1 
ATOM   3881 S SD   . MET B 1 267 ? 118.451 100.589 122.718 1.00 54.95  ? 267 MET A SD   1 
ATOM   3882 C CE   . MET B 1 267 ? 120.017 100.548 121.855 1.00 40.66  ? 267 MET A CE   1 
ATOM   3883 N N    . GLY B 1 268 ? 120.773 105.750 121.384 1.00 25.85  ? 268 GLY A N    1 
ATOM   3884 C CA   . GLY B 1 268 ? 121.986 106.522 121.175 1.00 20.44  ? 268 GLY A CA   1 
ATOM   3885 C C    . GLY B 1 268 ? 121.863 107.958 121.649 1.00 22.98  ? 268 GLY A C    1 
ATOM   3886 O O    . GLY B 1 268 ? 122.777 108.491 122.286 1.00 24.44  ? 268 GLY A O    1 
ATOM   3887 N N    . VAL B 1 269 ? 120.724 108.595 121.364 1.00 25.79  ? 269 VAL A N    1 
ATOM   3888 C CA   . VAL B 1 269 ? 120.525 109.975 121.796 1.00 25.70  ? 269 VAL A CA   1 
ATOM   3889 C C    . VAL B 1 269 ? 120.523 110.064 123.318 1.00 29.16  ? 269 VAL A C    1 
ATOM   3890 O O    . VAL B 1 269 ? 121.154 110.959 123.901 1.00 40.21  ? 269 VAL A O    1 
ATOM   3891 C CB   . VAL B 1 269 ? 119.234 110.552 121.187 1.00 32.18  ? 269 VAL A CB   1 
ATOM   3892 C CG1  . VAL B 1 269 ? 118.895 111.887 121.826 1.00 30.77  ? 269 VAL A CG1  1 
ATOM   3893 C CG2  . VAL B 1 269 ? 119.392 110.722 119.685 1.00 30.71  ? 269 VAL A CG2  1 
ATOM   3894 N N    . CYS B 1 270 ? 119.838 109.128 123.986 1.00 34.79  ? 270 CYS A N    1 
ATOM   3895 C CA   . CYS B 1 270 ? 119.834 109.129 125.450 1.00 31.29  ? 270 CYS A CA   1 
ATOM   3896 C C    . CYS B 1 270 ? 121.252 109.013 126.012 1.00 32.44  ? 270 CYS A C    1 
ATOM   3897 O O    . CYS B 1 270 ? 121.664 109.797 126.889 1.00 41.43  ? 270 CYS A O    1 
ATOM   3898 C CB   . CYS B 1 270 ? 118.953 107.994 125.966 1.00 30.34  ? 270 CYS A CB   1 
ATOM   3899 S SG   . CYS B 1 270 ? 117.190 108.193 125.615 1.00 57.72  ? 270 CYS A SG   1 
ATOM   3900 N N    . CYS B 1 271 ? 122.021 108.042 125.511 1.00 24.74  ? 271 CYS A N    1 
ATOM   3901 C CA   . CYS B 1 271 ? 123.359 107.807 126.049 1.00 25.77  ? 271 CYS A CA   1 
ATOM   3902 C C    . CYS B 1 271 ? 124.274 109.005 125.828 1.00 31.52  ? 271 CYS A C    1 
ATOM   3903 O O    . CYS B 1 271 ? 125.021 109.405 126.735 1.00 38.57  ? 271 CYS A O    1 
ATOM   3904 C CB   . CYS B 1 271 ? 123.958 106.545 125.425 1.00 31.86  ? 271 CYS A CB   1 
ATOM   3905 S SG   . CYS B 1 271 ? 123.137 105.014 125.916 1.00 56.02  ? 271 CYS A SG   1 
ATOM   3906 N N    . ILE B 1 272 ? 124.217 109.612 124.640 1.00 27.93  ? 272 ILE A N    1 
ATOM   3907 C CA   . ILE B 1 272 ? 125.110 110.732 124.350 1.00 29.30  ? 272 ILE A CA   1 
ATOM   3908 C C    . ILE B 1 272 ? 124.716 111.960 125.165 1.00 31.26  ? 272 ILE A C    1 
ATOM   3909 O O    . ILE B 1 272 ? 125.585 112.718 125.624 1.00 32.09  ? 272 ILE A O    1 
ATOM   3910 C CB   . ILE B 1 272 ? 125.125 111.020 122.841 1.00 29.57  ? 272 ILE A CB   1 
ATOM   3911 C CG1  . ILE B 1 272 ? 125.774 109.853 122.095 1.00 26.72  ? 272 ILE A CG1  1 
ATOM   3912 C CG2  . ILE B 1 272 ? 125.867 112.317 122.545 1.00 24.20  ? 272 ILE A CG2  1 
ATOM   3913 C CD1  . ILE B 1 272 ? 127.232 109.656 122.431 1.00 23.37  ? 272 ILE A CD1  1 
ATOM   3914 N N    . ALA B 1 273 ? 123.415 112.172 125.378 1.00 31.70  ? 273 ALA A N    1 
ATOM   3915 C CA   . ALA B 1 273 ? 122.970 113.259 126.244 1.00 29.13  ? 273 ALA A CA   1 
ATOM   3916 C C    . ALA B 1 273 ? 123.543 113.111 127.652 1.00 37.56  ? 273 ALA A C    1 
ATOM   3917 O O    . ALA B 1 273 ? 124.091 114.070 128.226 1.00 38.44  ? 273 ALA A O    1 
ATOM   3918 C CB   . ALA B 1 273 ? 121.450 113.312 126.291 1.00 30.00  ? 273 ALA A CB   1 
ATOM   3919 N N    . SER B 1 274 ? 123.438 111.907 128.222 1.00 37.45  ? 274 SER A N    1 
ATOM   3920 C CA   . SER B 1 274 ? 123.976 111.684 129.563 1.00 31.17  ? 274 SER A CA   1 
ATOM   3921 C C    . SER B 1 274 ? 125.489 111.896 129.606 1.00 32.16  ? 274 SER A C    1 
ATOM   3922 O O    . SER B 1 274 ? 126.018 112.505 130.553 1.00 43.56  ? 274 SER A O    1 
ATOM   3923 C CB   . SER B 1 274 ? 123.617 110.276 130.031 1.00 35.29  ? 274 SER A CB   1 
ATOM   3924 O OG   . SER B 1 274 ? 122.237 110.020 129.858 1.00 40.50  ? 274 SER A OG   1 
ATOM   3925 N N    . LEU B 1 275 ? 126.199 111.413 128.581 1.00 29.54  ? 275 LEU A N    1 
ATOM   3926 C CA   . LEU B 1 275 ? 127.651 111.577 128.546 1.00 32.71  ? 275 LEU A CA   1 
ATOM   3927 C C    . LEU B 1 275 ? 128.038 113.052 128.500 1.00 36.02  ? 275 LEU A C    1 
ATOM   3928 O O    . LEU B 1 275 ? 128.974 113.480 129.191 1.00 38.48  ? 275 LEU A O    1 
ATOM   3929 C CB   . LEU B 1 275 ? 128.233 110.827 127.348 1.00 27.04  ? 275 LEU A CB   1 
ATOM   3930 C CG   . LEU B 1 275 ? 129.759 110.826 127.238 1.00 30.45  ? 275 LEU A CG   1 
ATOM   3931 C CD1  . LEU B 1 275 ? 130.378 110.217 128.484 1.00 29.06  ? 275 LEU A CD1  1 
ATOM   3932 C CD2  . LEU B 1 275 ? 130.218 110.086 125.993 1.00 29.72  ? 275 LEU A CD2  1 
ATOM   3933 N N    . PHE B 1 276 ? 127.329 113.843 127.691 1.00 31.39  ? 276 PHE A N    1 
ATOM   3934 C CA   . PHE B 1 276 ? 127.618 115.270 127.602 1.00 20.42  ? 276 PHE A CA   1 
ATOM   3935 C C    . PHE B 1 276 ? 127.387 115.967 128.937 1.00 25.45  ? 276 PHE A C    1 
ATOM   3936 O O    . PHE B 1 276 ? 128.177 116.834 129.334 1.00 30.80  ? 276 PHE A O    1 
ATOM   3937 C CB   . PHE B 1 276 ? 126.774 115.916 126.504 1.00 24.14  ? 276 PHE A CB   1 
ATOM   3938 C CG   . PHE B 1 276 ? 127.320 115.713 125.121 1.00 29.74  ? 276 PHE A CG   1 
ATOM   3939 C CD1  . PHE B 1 276 ? 128.492 115.003 124.919 1.00 30.28  ? 276 PHE A CD1  1 
ATOM   3940 C CD2  . PHE B 1 276 ? 126.670 116.249 124.021 1.00 26.00  ? 276 PHE A CD2  1 
ATOM   3941 C CE1  . PHE B 1 276 ? 128.997 114.819 123.646 1.00 26.99  ? 276 PHE A CE1  1 
ATOM   3942 C CE2  . PHE B 1 276 ? 127.172 116.069 122.749 1.00 25.05  ? 276 PHE A CE2  1 
ATOM   3943 C CZ   . PHE B 1 276 ? 128.336 115.354 122.560 1.00 24.12  ? 276 PHE A CZ   1 
ATOM   3944 N N    . ASN B 1 277 ? 126.318 115.603 129.651 1.00 33.49  ? 277 ASN A N    1 
ATOM   3945 C CA   . ASN B 1 277 ? 126.080 116.228 130.953 1.00 25.92  ? 277 ASN A CA   1 
ATOM   3946 C C    . ASN B 1 277 ? 127.209 115.916 131.938 1.00 29.55  ? 277 ASN A C    1 
ATOM   3947 O O    . ASN B 1 277 ? 127.693 116.808 132.656 1.00 38.69  ? 277 ASN A O    1 
ATOM   3948 C CB   . ASN B 1 277 ? 124.735 115.763 131.515 1.00 27.59  ? 277 ASN A CB   1 
ATOM   3949 C CG   . ASN B 1 277 ? 123.584 116.648 131.078 1.00 38.44  ? 277 ASN A CG   1 
ATOM   3950 O OD1  . ASN B 1 277 ? 123.338 116.822 129.882 1.00 27.07  ? 277 ASN A OD1  1 
ATOM   3951 N ND2  . ASN B 1 277 ? 122.868 117.210 132.043 1.00 43.84  ? 277 ASN A ND2  1 
ATOM   3952 N N    . VAL B 1 278 ? 127.662 114.659 131.966 1.00 28.09  ? 278 VAL A N    1 
ATOM   3953 C CA   . VAL B 1 278 ? 128.745 114.295 132.881 1.00 27.94  ? 278 VAL A CA   1 
ATOM   3954 C C    . VAL B 1 278 ? 130.035 115.036 132.524 1.00 33.97  ? 278 VAL A C    1 
ATOM   3955 O O    . VAL B 1 278 ? 130.753 115.538 133.408 1.00 38.28  ? 278 VAL A O    1 
ATOM   3956 C CB   . VAL B 1 278 ? 128.943 112.767 132.881 1.00 31.98  ? 278 VAL A CB   1 
ATOM   3957 C CG1  . VAL B 1 278 ? 130.185 112.389 133.663 1.00 37.67  ? 278 VAL A CG1  1 
ATOM   3958 C CG2  . VAL B 1 278 ? 127.720 112.081 133.467 1.00 30.42  ? 278 VAL A CG2  1 
ATOM   3959 N N    . ILE B 1 279 ? 130.343 115.128 131.228 1.00 31.35  ? 279 ILE A N    1 
ATOM   3960 C CA   . ILE B 1 279 ? 131.557 115.831 130.818 1.00 26.80  ? 279 ILE A CA   1 
ATOM   3961 C C    . ILE B 1 279 ? 131.473 117.314 131.167 1.00 32.19  ? 279 ILE A C    1 
ATOM   3962 O O    . ILE B 1 279 ? 132.480 117.928 131.538 1.00 37.80  ? 279 ILE A O    1 
ATOM   3963 C CB   . ILE B 1 279 ? 131.821 115.618 129.314 1.00 28.44  ? 279 ILE A CB   1 
ATOM   3964 C CG1  . ILE B 1 279 ? 132.213 114.168 129.039 1.00 27.47  ? 279 ILE A CG1  1 
ATOM   3965 C CG2  . ILE B 1 279 ? 132.927 116.533 128.823 1.00 29.11  ? 279 ILE A CG2  1 
ATOM   3966 C CD1  . ILE B 1 279 ? 132.126 113.784 127.579 1.00 26.44  ? 279 ILE A CD1  1 
ATOM   3967 N N    . SER B 1 280 ? 130.277 117.907 131.078 1.00 33.94  ? 280 SER A N    1 
ATOM   3968 C CA   . SER B 1 280 ? 130.117 119.304 131.480 1.00 25.26  ? 280 SER A CA   1 
ATOM   3969 C C    . SER B 1 280 ? 130.403 119.493 132.967 1.00 29.07  ? 280 SER A C    1 
ATOM   3970 O O    . SER B 1 280 ? 131.037 120.482 133.366 1.00 34.12  ? 280 SER A O    1 
ATOM   3971 C CB   . SER B 1 280 ? 128.708 119.787 131.138 1.00 23.90  ? 280 SER A CB   1 
ATOM   3972 O OG   . SER B 1 280 ? 127.868 119.762 132.277 1.00 34.91  ? 280 SER A OG   1 
ATOM   3973 N N    . ILE B 1 281 ? 129.946 118.554 133.801 1.00 34.84  ? 281 ILE A N    1 
ATOM   3974 C CA   . ILE B 1 281 ? 130.255 118.638 135.232 1.00 34.39  ? 281 ILE A CA   1 
ATOM   3975 C C    . ILE B 1 281 ? 131.766 118.591 135.462 1.00 36.93  ? 281 ILE A C    1 
ATOM   3976 O O    . ILE B 1 281 ? 132.329 119.384 136.243 1.00 43.87  ? 281 ILE A O    1 
ATOM   3977 C CB   . ILE B 1 281 ? 129.531 117.516 135.998 1.00 35.35  ? 281 ILE A CB   1 
ATOM   3978 C CG1  . ILE B 1 281 ? 128.020 117.740 135.966 1.00 34.75  ? 281 ILE A CG1  1 
ATOM   3979 C CG2  . ILE B 1 281 ? 130.025 117.439 137.437 1.00 35.02  ? 281 ILE A CG2  1 
ATOM   3980 C CD1  . ILE B 1 281 ? 127.232 116.675 136.686 1.00 38.42  ? 281 ILE A CD1  1 
ATOM   3981 N N    . LEU B 1 282 ? 132.451 117.674 134.772 1.00 29.90  ? 282 LEU A N    1 
ATOM   3982 C CA   . LEU B 1 282 ? 133.899 117.574 134.925 1.00 32.98  ? 282 LEU A CA   1 
ATOM   3983 C C    . LEU B 1 282 ? 134.606 118.850 134.467 1.00 34.91  ? 282 LEU A C    1 
ATOM   3984 O O    . LEU B 1 282 ? 135.578 119.295 135.092 1.00 38.74  ? 282 LEU A O    1 
ATOM   3985 C CB   . LEU B 1 282 ? 134.424 116.362 134.156 1.00 37.48  ? 282 LEU A CB   1 
ATOM   3986 C CG   . LEU B 1 282 ? 134.186 115.001 134.819 1.00 37.31  ? 282 LEU A CG   1 
ATOM   3987 C CD1  . LEU B 1 282 ? 134.783 113.885 133.983 1.00 37.59  ? 282 LEU A CD1  1 
ATOM   3988 C CD2  . LEU B 1 282 ? 134.749 114.982 136.230 1.00 33.92  ? 282 LEU A CD2  1 
ATOM   3989 N N    . ILE B 1 283 ? 134.123 119.456 133.378 1.00 35.68  ? 283 ILE A N    1 
ATOM   3990 C CA   . ILE B 1 283 ? 134.723 120.696 132.882 1.00 31.03  ? 283 ILE A CA   1 
ATOM   3991 C C    . ILE B 1 283 ? 134.547 121.824 133.894 1.00 30.47  ? 283 ILE A C    1 
ATOM   3992 O O    . ILE B 1 283 ? 135.446 122.650 134.087 1.00 35.33  ? 283 ILE A O    1 
ATOM   3993 C CB   . ILE B 1 283 ? 134.128 121.063 131.510 1.00 27.14  ? 283 ILE A CB   1 
ATOM   3994 C CG1  . ILE B 1 283 ? 134.625 120.093 130.440 1.00 31.26  ? 283 ILE A CG1  1 
ATOM   3995 C CG2  . ILE B 1 283 ? 134.486 122.495 131.130 1.00 26.61  ? 283 ILE A CG2  1 
ATOM   3996 C CD1  . ILE B 1 283 ? 134.141 120.427 129.048 1.00 31.13  ? 283 ILE A CD1  1 
ATOM   3997 N N    . LYS B 1 284 ? 133.384 121.880 134.553 1.00 33.90  ? 284 LYS A N    1 
ATOM   3998 C CA   . LYS B 1 284 ? 133.191 122.896 135.587 1.00 32.18  ? 284 LYS A CA   1 
ATOM   3999 C C    . LYS B 1 284 ? 134.179 122.710 136.736 1.00 32.77  ? 284 LYS A C    1 
ATOM   4000 O O    . LYS B 1 284 ? 134.745 123.691 137.249 1.00 36.15  ? 284 LYS A O    1 
ATOM   4001 C CB   . LYS B 1 284 ? 131.754 122.862 136.107 1.00 27.16  ? 284 LYS A CB   1 
ATOM   4002 C CG   . LYS B 1 284 ? 131.438 123.979 137.088 1.00 27.97  ? 284 LYS A CG   1 
ATOM   4003 C CD   . LYS B 1 284 ? 130.305 123.595 138.025 1.00 35.57  ? 284 LYS A CD   1 
ATOM   4004 C CE   . LYS B 1 284 ? 129.837 124.786 138.844 1.00 35.57  ? 284 LYS A CE   1 
ATOM   4005 N NZ   . LYS B 1 284 ? 129.266 125.860 137.987 1.00 36.04  ? 284 LYS A NZ   1 
ATOM   4006 N N    . GLN B 1 285 ? 134.403 121.460 137.152 1.00 37.86  ? 285 GLN A N    1 
ATOM   4007 C CA   . GLN B 1 285 ? 135.402 121.216 138.194 1.00 35.80  ? 285 GLN A CA   1 
ATOM   4008 C C    . GLN B 1 285 ? 136.796 121.659 137.750 1.00 39.42  ? 285 GLN A C    1 
ATOM   4009 O O    . GLN B 1 285 ? 137.558 122.245 138.538 1.00 40.50  ? 285 GLN A O    1 
ATOM   4010 C CB   . GLN B 1 285 ? 135.410 119.742 138.600 1.00 36.93  ? 285 GLN A CB   1 
ATOM   4011 C CG   . GLN B 1 285 ? 134.134 119.286 139.287 1.00 43.67  ? 285 GLN A CG   1 
ATOM   4012 C CD   . GLN B 1 285 ? 134.294 117.949 139.984 1.00 52.89  ? 285 GLN A CD   1 
ATOM   4013 O OE1  . GLN B 1 285 ? 135.381 117.373 140.003 1.00 53.84  ? 285 GLN A OE1  1 
ATOM   4014 N NE2  . GLN B 1 285 ? 133.210 117.453 140.565 1.00 50.08  ? 285 GLN A NE2  1 
ATOM   4015 N N    . SER B 1 286 ? 137.149 121.390 136.493 1.00 40.05  ? 286 SER A N    1 
ATOM   4016 C CA   . SER B 1 286 ? 138.459 121.808 135.993 1.00 32.16  ? 286 SER A CA   1 
ATOM   4017 C C    . SER B 1 286 ? 138.589 123.326 135.980 1.00 38.22  ? 286 SER A C    1 
ATOM   4018 O O    . SER B 1 286 ? 139.657 123.868 136.290 1.00 42.35  ? 286 SER A O    1 
ATOM   4019 C CB   . SER B 1 286 ? 138.703 121.239 134.594 1.00 37.96  ? 286 SER A CB   1 
ATOM   4020 O OG   . SER B 1 286 ? 137.699 121.661 133.689 1.00 42.59  ? 286 SER A OG   1 
ATOM   4021 N N    . LEU B 1 287 ? 137.518 124.031 135.603 1.00 42.33  ? 287 LEU A N    1 
ATOM   4022 C CA   . LEU B 1 287 ? 137.545 125.491 135.645 1.00 34.08  ? 287 LEU A CA   1 
ATOM   4023 C C    . LEU B 1 287 ? 137.753 125.997 137.069 1.00 35.06  ? 287 LEU A C    1 
ATOM   4024 O O    . LEU B 1 287 ? 138.501 126.961 137.289 1.00 38.24  ? 287 LEU A O    1 
ATOM   4025 C CB   . LEU B 1 287 ? 136.251 126.062 135.071 1.00 34.83  ? 287 LEU A CB   1 
ATOM   4026 C CG   . LEU B 1 287 ? 136.094 126.071 133.554 1.00 33.06  ? 287 LEU A CG   1 
ATOM   4027 C CD1  . LEU B 1 287 ? 134.763 126.691 133.180 1.00 33.64  ? 287 LEU A CD1  1 
ATOM   4028 C CD2  . LEU B 1 287 ? 137.242 126.826 132.911 1.00 35.75  ? 287 LEU A CD2  1 
ATOM   4029 N N    . ASN B 1 288 ? 137.091 125.372 138.044 1.00 45.70  ? 288 ASN A N    1 
ATOM   4030 C CA   . ASN B 1 288 ? 137.305 125.768 139.435 1.00 41.38  ? 288 ASN A CA   1 
ATOM   4031 C C    . ASN B 1 288 ? 138.763 125.578 139.843 1.00 44.47  ? 288 ASN A C    1 
ATOM   4032 O O    . ASN B 1 288 ? 139.352 126.447 140.503 1.00 45.12  ? 288 ASN A O    1 
ATOM   4033 C CB   . ASN B 1 288 ? 136.386 124.974 140.365 1.00 42.00  ? 288 ASN A CB   1 
ATOM   4034 C CG   . ASN B 1 288 ? 135.062 125.665 140.602 1.00 47.01  ? 288 ASN A CG   1 
ATOM   4035 O OD1  . ASN B 1 288 ? 134.987 126.891 140.649 1.00 54.27  ? 288 ASN A OD1  1 
ATOM   4036 N ND2  . ASN B 1 288 ? 134.005 124.877 140.770 1.00 47.41  ? 288 ASN A ND2  1 
ATOM   4037 N N    . TRP B 1 289 ? 139.361 124.451 139.453 1.00 48.02  ? 289 TRP A N    1 
ATOM   4038 C CA   . TRP B 1 289 ? 140.773 124.223 139.766 1.00 46.93  ? 289 TRP A CA   1 
ATOM   4039 C C    . TRP B 1 289 ? 141.664 125.272 139.111 1.00 48.78  ? 289 TRP A C    1 
ATOM   4040 O O    . TRP B 1 289 ? 142.606 125.777 139.737 1.00 54.66  ? 289 TRP A O    1 
ATOM   4041 C CB   . TRP B 1 289 ? 141.193 122.824 139.325 1.00 51.79  ? 289 TRP A CB   1 
ATOM   4042 C CG   . TRP B 1 289 ? 142.629 122.526 139.624 1.00 54.73  ? 289 TRP A CG   1 
ATOM   4043 C CD1  . TRP B 1 289 ? 143.156 122.150 140.823 1.00 51.93  ? 289 TRP A CD1  1 
ATOM   4044 C CD2  . TRP B 1 289 ? 143.731 122.612 138.712 1.00 55.68  ? 289 TRP A CD2  1 
ATOM   4045 N NE1  . TRP B 1 289 ? 144.515 121.980 140.712 1.00 48.01  ? 289 TRP A NE1  1 
ATOM   4046 C CE2  . TRP B 1 289 ? 144.893 122.259 139.425 1.00 51.76  ? 289 TRP A CE2  1 
ATOM   4047 C CE3  . TRP B 1 289 ? 143.846 122.949 137.358 1.00 53.32  ? 289 TRP A CE3  1 
ATOM   4048 C CZ2  . TRP B 1 289 ? 146.154 122.233 138.834 1.00 52.64  ? 289 TRP A CZ2  1 
ATOM   4049 C CZ3  . TRP B 1 289 ? 145.098 122.920 136.773 1.00 52.73  ? 289 TRP A CZ3  1 
ATOM   4050 C CH2  . TRP B 1 289 ? 146.237 122.565 137.510 1.00 53.56  ? 289 TRP A CH2  1 
ATOM   4051 N N    . ILE B 1 290 ? 141.380 125.613 137.852 1.00 53.97  ? 290 ILE A N    1 
ATOM   4052 C CA   . ILE B 1 290 ? 142.185 126.612 137.147 1.00 52.94  ? 290 ILE A CA   1 
ATOM   4053 C C    . ILE B 1 290 ? 142.109 127.955 137.856 1.00 52.17  ? 290 ILE A C    1 
ATOM   4054 O O    . ILE B 1 290 ? 143.124 128.638 138.037 1.00 50.31  ? 290 ILE A O    1 
ATOM   4055 C CB   . ILE B 1 290 ? 141.742 126.719 135.674 1.00 51.99  ? 290 ILE A CB   1 
ATOM   4056 C CG1  . ILE B 1 290 ? 142.527 125.738 134.804 1.00 54.17  ? 290 ILE A CG1  1 
ATOM   4057 C CG2  . ILE B 1 290 ? 141.946 128.132 135.148 1.00 50.52  ? 290 ILE A CG2  1 
ATOM   4058 C CD1  . ILE B 1 290 ? 142.069 125.710 133.365 1.00 50.49  ? 290 ILE A CD1  1 
ATOM   4059 N N    . LEU B 1 291 ? 140.902 128.363 138.264 1.00 56.81  ? 291 LEU A N    1 
ATOM   4060 C CA   . LEU B 1 291 ? 140.764 129.630 138.973 1.00 51.50  ? 291 LEU A CA   1 
ATOM   4061 C C    . LEU B 1 291 ? 141.513 129.611 140.297 1.00 52.44  ? 291 LEU A C    1 
ATOM   4062 O O    . LEU B 1 291 ? 142.186 130.588 140.649 1.00 54.06  ? 291 LEU A O    1 
ATOM   4063 C CB   . LEU B 1 291 ? 139.289 129.953 139.207 1.00 48.53  ? 291 LEU A CB   1 
ATOM   4064 C CG   . LEU B 1 291 ? 138.523 130.577 138.041 1.00 47.83  ? 291 LEU A CG   1 
ATOM   4065 C CD1  . LEU B 1 291 ? 137.090 130.866 138.450 1.00 49.95  ? 291 LEU A CD1  1 
ATOM   4066 C CD2  . LEU B 1 291 ? 139.214 131.847 137.574 1.00 48.38  ? 291 LEU A CD2  1 
ATOM   4067 N N    . ARG B 1 292 ? 141.410 128.512 141.049 1.00 65.48  ? 292 ARG A N    1 
ATOM   4068 C CA   . ARG B 1 292 ? 142.096 128.443 142.338 1.00 64.60  ? 292 ARG A CA   1 
ATOM   4069 C C    . ARG B 1 292 ? 143.612 128.503 142.183 1.00 64.50  ? 292 ARG A C    1 
ATOM   4070 O O    . ARG B 1 292 ? 144.293 129.174 142.968 1.00 64.12  ? 292 ARG A O    1 
ATOM   4071 C CB   . ARG B 1 292 ? 141.682 127.184 143.102 1.00 65.40  ? 292 ARG A CB   1 
ATOM   4072 C CG   . ARG B 1 292 ? 141.674 127.382 144.613 1.00 66.93  ? 292 ARG A CG   1 
ATOM   4073 C CD   . ARG B 1 292 ? 140.694 126.468 145.323 1.00 68.09  ? 292 ARG A CD   1 
ATOM   4074 N NE   . ARG B 1 292 ? 139.325 126.653 144.854 1.00 71.65  ? 292 ARG A NE   1 
ATOM   4075 C CZ   . ARG B 1 292 ? 138.396 125.706 144.862 1.00 71.10  ? 292 ARG A CZ   1 
ATOM   4076 N NH1  . ARG B 1 292 ? 138.658 124.485 145.296 1.00 68.05  ? 292 ARG A NH1  1 
ATOM   4077 N NH2  . ARG B 1 292 ? 137.173 125.993 144.424 1.00 67.32  ? 292 ARG A NH2  1 
ATOM   4078 N N    . LYS B 1 293 ? 144.162 127.807 141.185 1.00 72.19  ? 293 LYS A N    1 
ATOM   4079 C CA   . LYS B 1 293 ? 145.612 127.811 141.004 1.00 75.15  ? 293 LYS A CA   1 
ATOM   4080 C C    . LYS B 1 293 ? 146.144 129.195 140.639 1.00 74.36  ? 293 LYS A C    1 
ATOM   4081 O O    . LYS B 1 293 ? 147.171 129.629 141.176 1.00 76.01  ? 293 LYS A O    1 
ATOM   4082 C CB   . LYS B 1 293 ? 146.018 126.789 139.944 1.00 74.22  ? 293 LYS A CB   1 
ATOM   4083 C CG   . LYS B 1 293 ? 147.505 126.800 139.618 1.00 73.94  ? 293 LYS A CG   1 
ATOM   4084 C CD   . LYS B 1 293 ? 148.353 126.494 140.846 1.00 73.71  ? 293 LYS A CD   1 
ATOM   4085 C CE   . LYS B 1 293 ? 148.087 125.099 141.378 1.00 73.42  ? 293 LYS A CE   1 
ATOM   4086 N NZ   . LYS B 1 293 ? 148.398 124.055 140.365 1.00 73.02  ? 293 LYS A NZ   1 
ATOM   4087 N N    . MET B 1 294 ? 145.468 129.903 139.738 1.00 79.24  ? 294 MET A N    1 
ATOM   4088 C CA   . MET B 1 294 ? 145.953 131.210 139.310 1.00 78.60  ? 294 MET A CA   1 
ATOM   4089 C C    . MET B 1 294 ? 145.748 132.252 140.402 1.00 80.59  ? 294 MET A C    1 
ATOM   4090 O O    . MET B 1 294 ? 144.667 132.352 140.990 1.00 80.80  ? 294 MET A O    1 
ATOM   4091 C CB   . MET B 1 294 ? 145.241 131.643 138.027 1.00 78.30  ? 294 MET A CB   1 
ATOM   4092 C CG   . MET B 1 294 ? 145.324 133.135 137.742 1.00 78.69  ? 294 MET A CG   1 
ATOM   4093 S SD   . MET B 1 294 ? 144.311 133.670 136.346 1.00 90.31  ? 294 MET A SD   1 
ATOM   4094 C CE   . MET B 1 294 ? 143.972 132.109 135.536 1.00 77.72  ? 294 MET A CE   1 
ATOM   4095 N N    . ASP B 1 295 ? 146.793 133.029 140.672 1.00 88.60  ? 295 ASP A N    1 
ATOM   4096 C CA   . ASP B 1 295 ? 146.742 134.092 141.671 1.00 89.77  ? 295 ASP A CA   1 
ATOM   4097 C C    . ASP B 1 295 ? 147.437 135.351 141.157 1.00 90.39  ? 295 ASP A C    1 
ATOM   4098 O O    . ASP B 1 295 ? 148.593 135.612 141.490 1.00 91.66  ? 295 ASP A O    1 
ATOM   4099 C CB   . ASP B 1 295 ? 147.385 133.640 142.982 1.00 87.29  ? 295 ASP A CB   1 
ATOM   4100 C CG   . ASP B 1 295 ? 146.400 132.960 143.911 1.00 88.11  ? 295 ASP A CG   1 
ATOM   4101 O OD1  . ASP B 1 295 ? 145.177 133.079 143.677 1.00 85.39  ? 295 ASP A OD1  1 
ATOM   4102 O OD2  . ASP B 1 295 ? 146.847 132.307 144.878 1.00 90.23  ? 295 ASP A OD2  1 
HETATM 4103 C C1   . D12 C 2 .   ? 133.692 139.438 111.123 1.00 20.00  ? 401 D12 U C1   1 
HETATM 4104 C C2   . D12 C 2 .   ? 133.390 138.714 112.429 1.00 20.00  ? 401 D12 U C2   1 
HETATM 4105 C C3   . D12 C 2 .   ? 133.590 137.211 112.301 1.00 20.00  ? 401 D12 U C3   1 
HETATM 4106 C C4   . D12 C 2 .   ? 135.059 136.807 112.392 1.00 20.00  ? 401 D12 U C4   1 
HETATM 4107 C C5   . D12 C 2 .   ? 135.475 136.247 113.741 1.00 20.00  ? 401 D12 U C5   1 
HETATM 4108 C C6   . D12 C 2 .   ? 135.136 137.165 114.901 1.00 20.00  ? 401 D12 U C6   1 
HETATM 4109 C C7   . D12 C 2 .   ? 135.318 136.475 116.235 1.00 20.00  ? 401 D12 U C7   1 
HETATM 4110 C C8   . D12 C 2 .   ? 135.315 137.456 117.386 1.00 20.00  ? 401 D12 U C8   1 
HETATM 4111 C C9   . D12 C 2 .   ? 133.917 137.987 117.648 1.00 20.00  ? 401 D12 U C9   1 
HETATM 4112 C C10  . D12 C 2 .   ? 133.563 137.816 119.114 1.00 20.00  ? 401 D12 U C10  1 
HETATM 4113 C C11  . D12 C 2 .   ? 134.242 138.856 119.991 1.00 20.00  ? 401 D12 U C11  1 
HETATM 4114 C C12  . D12 C 2 .   ? 135.258 138.249 120.944 1.00 20.00  ? 401 D12 U C12  1 
HETATM 4115 H H11  . D12 C 2 .   ? 134.762 139.423 110.941 1.00 20.00  ? 401 D12 U H11  1 
HETATM 4116 H H12  . D12 C 2 .   ? 133.347 140.465 111.192 1.00 20.00  ? 401 D12 U H12  1 
HETATM 4117 H H13  . D12 C 2 .   ? 133.177 138.937 110.308 1.00 20.00  ? 401 D12 U H13  1 
HETATM 4118 H H21  . D12 C 2 .   ? 132.360 138.910 112.706 1.00 20.00  ? 401 D12 U H21  1 
HETATM 4119 H H22  . D12 C 2 .   ? 134.046 139.098 113.203 1.00 20.00  ? 401 D12 U H22  1 
HETATM 4120 H H31  . D12 C 2 .   ? 133.202 136.893 111.339 1.00 20.00  ? 401 D12 U H31  1 
HETATM 4121 H H32  . D12 C 2 .   ? 133.033 136.709 113.085 1.00 20.00  ? 401 D12 U H32  1 
HETATM 4122 H H41  . D12 C 2 .   ? 135.671 137.677 112.183 1.00 20.00  ? 401 D12 U H41  1 
HETATM 4123 H H42  . D12 C 2 .   ? 135.255 136.054 111.636 1.00 20.00  ? 401 D12 U H42  1 
HETATM 4124 H H51  . D12 C 2 .   ? 134.978 135.297 113.894 1.00 20.00  ? 401 D12 U H51  1 
HETATM 4125 H H52  . D12 C 2 .   ? 136.547 136.084 113.733 1.00 20.00  ? 401 D12 U H52  1 
HETATM 4126 H H61  . D12 C 2 .   ? 135.779 138.037 114.862 1.00 20.00  ? 401 D12 U H61  1 
HETATM 4127 H H62  . D12 C 2 .   ? 134.103 137.483 114.836 1.00 20.00  ? 401 D12 U H62  1 
HETATM 4128 H H71  . D12 C 2 .   ? 134.495 135.787 116.380 1.00 20.00  ? 401 D12 U H71  1 
HETATM 4129 H H72  . D12 C 2 .   ? 136.252 135.923 116.230 1.00 20.00  ? 401 D12 U H72  1 
HETATM 4130 H H81  . D12 C 2 .   ? 135.972 138.285 117.147 1.00 20.00  ? 401 D12 U H81  1 
HETATM 4131 H H82  . D12 C 2 .   ? 135.681 136.955 118.275 1.00 20.00  ? 401 D12 U H82  1 
HETATM 4132 H H91  . D12 C 2 .   ? 133.205 137.436 117.044 1.00 20.00  ? 401 D12 U H91  1 
HETATM 4133 H H92  . D12 C 2 .   ? 133.875 139.038 117.385 1.00 20.00  ? 401 D12 U H92  1 
HETATM 4134 H H101 . D12 C 2 .   ? 132.487 137.904 119.228 1.00 20.00  ? 401 D12 U H101 1 
HETATM 4135 H H102 . D12 C 2 .   ? 133.873 136.828 119.438 1.00 20.00  ? 401 D12 U H102 1 
HETATM 4136 H H111 . D12 C 2 .   ? 133.485 139.371 120.572 1.00 20.00  ? 401 D12 U H111 1 
HETATM 4137 H H112 . D12 C 2 .   ? 134.747 139.575 119.355 1.00 20.00  ? 401 D12 U H112 1 
HETATM 4138 H H121 . D12 C 2 .   ? 135.942 137.617 120.386 1.00 20.00  ? 401 D12 U H121 1 
HETATM 4139 H H122 . D12 C 2 .   ? 135.813 139.042 121.435 1.00 20.00  ? 401 D12 U H122 1 
HETATM 4140 H H123 . D12 C 2 .   ? 134.739 137.652 121.688 1.00 20.00  ? 401 D12 U H123 1 
HETATM 4141 C C1   . D10 D 3 .   ? 123.087 148.091 108.492 1.00 20.00  ? 402 D10 U C1   1 
HETATM 4142 C C2   . D10 D 3 .   ? 122.879 147.333 109.792 1.00 20.00  ? 402 D10 U C2   1 
HETATM 4143 C C3   . D10 D 3 .   ? 124.200 147.041 110.485 1.00 20.00  ? 402 D10 U C3   1 
HETATM 4144 C C4   . D10 D 3 .   ? 123.976 146.497 111.880 1.00 20.00  ? 402 D10 U C4   1 
HETATM 4145 C C5   . D10 D 3 .   ? 123.839 147.598 112.904 1.00 20.00  ? 402 D10 U C5   1 
HETATM 4146 C C6   . D10 D 3 .   ? 123.675 146.999 114.287 1.00 20.00  ? 402 D10 U C6   1 
HETATM 4147 C C7   . D10 D 3 .   ? 124.957 147.126 115.098 1.00 20.00  ? 402 D10 U C7   1 
HETATM 4148 C C8   . D10 D 3 .   ? 124.686 147.273 116.579 1.00 20.00  ? 402 D10 U C8   1 
HETATM 4149 C C9   . D10 D 3 .   ? 124.052 146.019 117.141 1.00 20.00  ? 402 D10 U C9   1 
HETATM 4150 C C10  . D10 D 3 .   ? 124.312 145.867 118.628 1.00 20.00  ? 402 D10 U C10  1 
HETATM 4151 H H11  . D10 D 3 .   ? 123.552 149.044 108.711 1.00 20.00  ? 402 D10 U H11  1 
HETATM 4152 H H12  . D10 D 3 .   ? 123.734 147.515 107.845 1.00 20.00  ? 402 D10 U H12  1 
HETATM 4153 H H13  . D10 D 3 .   ? 122.132 148.250 108.009 1.00 20.00  ? 402 D10 U H13  1 
HETATM 4154 H H21  . D10 D 3 .   ? 122.380 146.398 109.581 1.00 20.00  ? 402 D10 U H21  1 
HETATM 4155 H H22  . D10 D 3 .   ? 122.261 147.929 110.450 1.00 20.00  ? 402 D10 U H22  1 
HETATM 4156 H H31  . D10 D 3 .   ? 124.769 147.958 110.556 1.00 20.00  ? 402 D10 U H31  1 
HETATM 4157 H H32  . D10 D 3 .   ? 124.751 146.316 109.904 1.00 20.00  ? 402 D10 U H32  1 
HETATM 4158 H H41  . D10 D 3 .   ? 124.812 145.869 112.156 1.00 20.00  ? 402 D10 U H41  1 
HETATM 4159 H H42  . D10 D 3 .   ? 123.069 145.908 111.882 1.00 20.00  ? 402 D10 U H42  1 
HETATM 4160 H H51  . D10 D 3 .   ? 124.718 148.224 112.867 1.00 20.00  ? 402 D10 U H51  1 
HETATM 4161 H H52  . D10 D 3 .   ? 122.967 148.192 112.667 1.00 20.00  ? 402 D10 U H52  1 
HETATM 4162 H H61  . D10 D 3 .   ? 122.877 147.512 114.806 1.00 20.00  ? 402 D10 U H61  1 
HETATM 4163 H H62  . D10 D 3 .   ? 123.424 145.953 114.187 1.00 20.00  ? 402 D10 U H62  1 
HETATM 4164 H H71  . D10 D 3 .   ? 125.556 146.241 114.938 1.00 20.00  ? 402 D10 U H71  1 
HETATM 4165 H H72  . D10 D 3 .   ? 125.509 147.994 114.766 1.00 20.00  ? 402 D10 U H72  1 
HETATM 4166 H H81  . D10 D 3 .   ? 124.019 148.109 116.737 1.00 20.00  ? 402 D10 U H81  1 
HETATM 4167 H H82  . D10 D 3 .   ? 125.620 147.455 117.096 1.00 20.00  ? 402 D10 U H82  1 
HETATM 4168 H H91  . D10 D 3 .   ? 124.456 145.162 116.623 1.00 20.00  ? 402 D10 U H91  1 
HETATM 4169 H H92  . D10 D 3 .   ? 122.983 146.064 116.978 1.00 20.00  ? 402 D10 U H92  1 
HETATM 4170 H H101 . D10 D 3 .   ? 123.924 146.734 119.148 1.00 20.00  ? 402 D10 U H101 1 
HETATM 4171 H H102 . D10 D 3 .   ? 125.378 145.794 118.796 1.00 20.00  ? 402 D10 U H102 1 
HETATM 4172 H H103 . D10 D 3 .   ? 123.821 144.971 118.993 1.00 20.00  ? 402 D10 U H103 1 
HETATM 4173 C C1   . OCT E 4 .   ? 139.707 139.040 109.294 1.00 20.00  ? 403 OCT U C1   1 
HETATM 4174 C C2   . OCT E 4 .   ? 139.859 139.260 110.783 1.00 20.00  ? 403 OCT U C2   1 
HETATM 4175 C C3   . OCT E 4 .   ? 140.436 138.022 111.430 1.00 20.00  ? 403 OCT U C3   1 
HETATM 4176 C C4   . OCT E 4 .   ? 139.912 137.826 112.836 1.00 20.00  ? 403 OCT U C4   1 
HETATM 4177 C C5   . OCT E 4 .   ? 140.410 138.896 113.785 1.00 20.00  ? 403 OCT U C5   1 
HETATM 4178 C C6   . OCT E 4 .   ? 140.536 138.342 115.187 1.00 20.00  ? 403 OCT U C6   1 
HETATM 4179 C C7   . OCT E 4 .   ? 140.842 139.454 116.173 1.00 20.00  ? 403 OCT U C7   1 
HETATM 4180 C C8   . OCT E 4 .   ? 140.651 138.999 117.608 1.00 20.00  ? 403 OCT U C8   1 
HETATM 4181 H H11  . OCT E 4 .   ? 139.491 139.982 108.808 1.00 20.00  ? 403 OCT U H11  1 
HETATM 4182 H H12  . OCT E 4 .   ? 140.628 138.628 108.903 1.00 20.00  ? 403 OCT U H12  1 
HETATM 4183 H H13  . OCT E 4 .   ? 138.897 138.343 109.120 1.00 20.00  ? 403 OCT U H13  1 
HETATM 4184 H H21  . OCT E 4 .   ? 138.891 139.468 111.217 1.00 20.00  ? 403 OCT U H21  1 
HETATM 4185 H H22  . OCT E 4 .   ? 140.520 140.099 110.959 1.00 20.00  ? 403 OCT U H22  1 
HETATM 4186 H H31  . OCT E 4 .   ? 140.171 137.164 110.830 1.00 20.00  ? 403 OCT U H31  1 
HETATM 4187 H H32  . OCT E 4 .   ? 141.514 138.115 111.467 1.00 20.00  ? 403 OCT U H32  1 
HETATM 4188 H H41  . OCT E 4 .   ? 138.830 137.856 112.814 1.00 20.00  ? 403 OCT U H41  1 
HETATM 4189 H H42  . OCT E 4 .   ? 140.236 136.863 113.204 1.00 20.00  ? 403 OCT U H42  1 
HETATM 4190 H H51  . OCT E 4 .   ? 139.713 139.724 113.791 1.00 20.00  ? 403 OCT U H51  1 
HETATM 4191 H H52  . OCT E 4 .   ? 141.379 139.247 113.453 1.00 20.00  ? 403 OCT U H52  1 
HETATM 4192 H H61  . OCT E 4 .   ? 139.606 137.868 115.465 1.00 20.00  ? 403 OCT U H61  1 
HETATM 4193 H H62  . OCT E 4 .   ? 141.336 137.614 115.211 1.00 20.00  ? 403 OCT U H62  1 
HETATM 4194 H H71  . OCT E 4 .   ? 141.868 139.773 116.034 1.00 20.00  ? 403 OCT U H71  1 
HETATM 4195 H H72  . OCT E 4 .   ? 140.180 140.286 115.975 1.00 20.00  ? 403 OCT U H72  1 
HETATM 4196 H H81  . OCT E 4 .   ? 141.022 139.761 118.282 1.00 20.00  ? 403 OCT U H81  1 
HETATM 4197 H H82  . OCT E 4 .   ? 139.598 138.829 117.789 1.00 20.00  ? 403 OCT U H82  1 
HETATM 4198 H H83  . OCT E 4 .   ? 141.198 138.077 117.761 1.00 20.00  ? 403 OCT U H83  1 
HETATM 4199 C C1   . OCT F 4 .   ? 135.433 145.226 110.735 1.00 20.00  ? 404 OCT U C1   1 
HETATM 4200 C C2   . OCT F 4 .   ? 134.823 145.777 112.010 1.00 20.00  ? 404 OCT U C2   1 
HETATM 4201 C C3   . OCT F 4 .   ? 134.952 144.793 113.150 1.00 20.00  ? 404 OCT U C3   1 
HETATM 4202 C C4   . OCT F 4 .   ? 133.761 144.940 114.066 1.00 20.00  ? 404 OCT U C4   1 
HETATM 4203 C C5   . OCT F 4 .   ? 134.017 144.216 115.367 1.00 20.00  ? 404 OCT U C5   1 
HETATM 4204 C C6   . OCT F 4 .   ? 133.968 145.143 116.562 1.00 20.00  ? 404 OCT U C6   1 
HETATM 4205 C C7   . OCT F 4 .   ? 134.876 144.633 117.662 1.00 20.00  ? 404 OCT U C7   1 
HETATM 4206 C C8   . OCT F 4 .   ? 134.144 144.569 118.987 1.00 20.00  ? 404 OCT U C8   1 
HETATM 4207 H H11  . OCT F 4 .   ? 134.732 144.545 110.270 1.00 20.00  ? 404 OCT U H11  1 
HETATM 4208 H H12  . OCT F 4 .   ? 135.657 146.042 110.059 1.00 20.00  ? 404 OCT U H12  1 
HETATM 4209 H H13  . OCT F 4 .   ? 136.344 144.695 110.982 1.00 20.00  ? 404 OCT U H13  1 
HETATM 4210 H H21  . OCT F 4 .   ? 133.772 145.977 111.844 1.00 20.00  ? 404 OCT U H21  1 
HETATM 4211 H H22  . OCT F 4 .   ? 135.326 146.696 112.277 1.00 20.00  ? 404 OCT U H22  1 
HETATM 4212 H H31  . OCT F 4 .   ? 134.983 143.786 112.757 1.00 20.00  ? 404 OCT U H31  1 
HETATM 4213 H H32  . OCT F 4 .   ? 135.859 145.000 113.703 1.00 20.00  ? 404 OCT U H32  1 
HETATM 4214 H H41  . OCT F 4 .   ? 133.592 145.993 114.258 1.00 20.00  ? 404 OCT U H41  1 
HETATM 4215 H H42  . OCT F 4 .   ? 132.890 144.519 113.583 1.00 20.00  ? 404 OCT U H42  1 
HETATM 4216 H H51  . OCT F 4 .   ? 134.994 143.757 115.314 1.00 20.00  ? 404 OCT U H51  1 
HETATM 4217 H H52  . OCT F 4 .   ? 133.272 143.443 115.496 1.00 20.00  ? 404 OCT U H52  1 
HETATM 4218 H H61  . OCT F 4 .   ? 134.295 146.130 116.264 1.00 20.00  ? 404 OCT U H61  1 
HETATM 4219 H H62  . OCT F 4 .   ? 132.955 145.195 116.935 1.00 20.00  ? 404 OCT U H62  1 
HETATM 4220 H H71  . OCT F 4 .   ? 135.224 143.639 117.411 1.00 20.00  ? 404 OCT U H71  1 
HETATM 4221 H H72  . OCT F 4 .   ? 135.727 145.296 117.759 1.00 20.00  ? 404 OCT U H72  1 
HETATM 4222 H H81  . OCT F 4 .   ? 133.727 145.543 119.208 1.00 20.00  ? 404 OCT U H81  1 
HETATM 4223 H H82  . OCT F 4 .   ? 133.346 143.842 118.915 1.00 20.00  ? 404 OCT U H82  1 
HETATM 4224 H H83  . OCT F 4 .   ? 134.834 144.279 119.768 1.00 20.00  ? 404 OCT U H83  1 
HETATM 4225 C C1   . D10 G 3 .   ? 117.824 149.297 108.997 1.00 20.00  ? 405 D10 U C1   1 
HETATM 4226 C C2   . D10 G 3 .   ? 117.758 147.845 109.439 1.00 20.00  ? 405 D10 U C2   1 
HETATM 4227 C C3   . D10 G 3 .   ? 118.191 147.669 110.879 1.00 20.00  ? 405 D10 U C3   1 
HETATM 4228 C C4   . D10 G 3 .   ? 117.145 148.101 111.881 1.00 20.00  ? 405 D10 U C4   1 
HETATM 4229 C C5   . D10 G 3 .   ? 117.779 148.117 113.246 1.00 20.00  ? 405 D10 U C5   1 
HETATM 4230 C C6   . D10 G 3 .   ? 116.944 147.371 114.260 1.00 20.00  ? 405 D10 U C6   1 
HETATM 4231 C C7   . D10 G 3 .   ? 117.755 147.027 115.492 1.00 20.00  ? 405 D10 U C7   1 
HETATM 4232 C C8   . D10 G 3 .   ? 117.950 148.253 116.353 1.00 20.00  ? 405 D10 U C8   1 
HETATM 4233 C C9   . D10 G 3 .   ? 117.358 148.083 117.731 1.00 20.00  ? 405 D10 U C9   1 
HETATM 4234 C C10  . D10 G 3 .   ? 118.395 147.537 118.698 1.00 20.00  ? 405 D10 U C10  1 
HETATM 4235 H H11  . D10 G 3 .   ? 116.929 149.808 109.324 1.00 20.00  ? 405 D10 U H11  1 
HETATM 4236 H H12  . D10 G 3 .   ? 118.693 149.764 109.443 1.00 20.00  ? 405 D10 U H12  1 
HETATM 4237 H H13  . D10 G 3 .   ? 117.899 149.340 107.918 1.00 20.00  ? 405 D10 U H13  1 
HETATM 4238 H H21  . D10 G 3 .   ? 118.400 147.250 108.803 1.00 20.00  ? 405 D10 U H21  1 
HETATM 4239 H H22  . D10 G 3 .   ? 116.738 147.496 109.342 1.00 20.00  ? 405 D10 U H22  1 
HETATM 4240 H H31  . D10 G 3 .   ? 119.084 148.257 111.045 1.00 20.00  ? 405 D10 U H31  1 
HETATM 4241 H H32  . D10 G 3 .   ? 118.418 146.628 111.052 1.00 20.00  ? 405 D10 U H32  1 
HETATM 4242 H H41  . D10 G 3 .   ? 116.320 147.402 111.867 1.00 20.00  ? 405 D10 U H41  1 
HETATM 4243 H H42  . D10 G 3 .   ? 116.789 149.093 111.636 1.00 20.00  ? 405 D10 U H42  1 
HETATM 4244 H H51  . D10 G 3 .   ? 118.754 147.650 113.185 1.00 20.00  ? 405 D10 U H51  1 
HETATM 4245 H H52  . D10 G 3 .   ? 117.896 149.144 113.570 1.00 20.00  ? 405 D10 U H52  1 
HETATM 4246 H H61  . D10 G 3 .   ? 116.103 147.987 114.547 1.00 20.00  ? 405 D10 U H61  1 
HETATM 4247 H H62  . D10 G 3 .   ? 116.584 146.455 113.812 1.00 20.00  ? 405 D10 U H62  1 
HETATM 4248 H H71  . D10 G 3 .   ? 117.242 146.262 116.057 1.00 20.00  ? 405 D10 U H71  1 
HETATM 4249 H H72  . D10 G 3 .   ? 118.723 146.656 115.183 1.00 20.00  ? 405 D10 U H72  1 
HETATM 4250 H H81  . D10 G 3 .   ? 117.480 149.103 115.878 1.00 20.00  ? 405 D10 U H81  1 
HETATM 4251 H H82  . D10 G 3 .   ? 119.009 148.444 116.452 1.00 20.00  ? 405 D10 U H82  1 
HETATM 4252 H H91  . D10 G 3 .   ? 116.519 147.403 117.682 1.00 20.00  ? 405 D10 U H91  1 
HETATM 4253 H H92  . D10 G 3 .   ? 117.019 149.044 118.087 1.00 20.00  ? 405 D10 U H92  1 
HETATM 4254 H H101 . D10 G 3 .   ? 119.178 148.270 118.829 1.00 20.00  ? 405 D10 U H101 1 
HETATM 4255 H H102 . D10 G 3 .   ? 118.813 146.626 118.291 1.00 20.00  ? 405 D10 U H102 1 
HETATM 4256 H H103 . D10 G 3 .   ? 117.923 147.329 119.652 1.00 20.00  ? 405 D10 U H103 1 
HETATM 4257 C C1   . HEX H 5 .   ? 96.181  106.985 113.097 1.00 20.00  ? 406 HEX U C1   1 
HETATM 4258 C C2   . HEX H 5 .   ? 94.951  107.797 113.479 1.00 20.00  ? 406 HEX U C2   1 
HETATM 4259 C C3   . HEX H 5 .   ? 95.191  108.628 114.731 1.00 20.00  ? 406 HEX U C3   1 
HETATM 4260 C C4   . HEX H 5 .   ? 95.465  107.748 115.942 1.00 20.00  ? 406 HEX U C4   1 
HETATM 4261 C C5   . HEX H 5 .   ? 94.837  108.324 117.201 1.00 20.00  ? 406 HEX U C5   1 
HETATM 4262 C C6   . HEX H 5 .   ? 95.447  109.669 117.568 1.00 20.00  ? 406 HEX U C6   1 
HETATM 4263 H H11  . HEX H 5 .   ? 96.145  106.025 113.595 1.00 20.00  ? 406 HEX U H11  1 
HETATM 4264 H H12  . HEX H 5 .   ? 97.068  107.522 113.406 1.00 20.00  ? 406 HEX U H12  1 
HETATM 4265 H H13  . HEX H 5 .   ? 96.197  106.840 112.025 1.00 20.00  ? 406 HEX U H13  1 
HETATM 4266 H H21  . HEX H 5 .   ? 94.127  107.123 113.663 1.00 20.00  ? 406 HEX U H21  1 
HETATM 4267 H H22  . HEX H 5 .   ? 94.697  108.460 112.662 1.00 20.00  ? 406 HEX U H22  1 
HETATM 4268 H H31  . HEX H 5 .   ? 94.314  109.231 114.924 1.00 20.00  ? 406 HEX U H31  1 
HETATM 4269 H H32  . HEX H 5 .   ? 96.041  109.275 114.566 1.00 20.00  ? 406 HEX U H32  1 
HETATM 4270 H H41  . HEX H 5 .   ? 95.053  106.762 115.765 1.00 20.00  ? 406 HEX U H41  1 
HETATM 4271 H H42  . HEX H 5 .   ? 96.534  107.669 116.085 1.00 20.00  ? 406 HEX U H42  1 
HETATM 4272 H H51  . HEX H 5 .   ? 93.777  108.453 117.032 1.00 20.00  ? 406 HEX U H51  1 
HETATM 4273 H H52  . HEX H 5 .   ? 94.989  107.631 118.017 1.00 20.00  ? 406 HEX U H52  1 
HETATM 4274 H H61  . HEX H 5 .   ? 95.403  109.806 118.641 1.00 20.00  ? 406 HEX U H61  1 
HETATM 4275 H H62  . HEX H 5 .   ? 94.893  110.458 117.076 1.00 20.00  ? 406 HEX U H62  1 
HETATM 4276 H H63  . HEX H 5 .   ? 96.480  109.692 117.238 1.00 20.00  ? 406 HEX U H63  1 
HETATM 4277 C C1   . EIC I 6 .   ? 129.014 134.897 110.482 1.00 20.00  ? 407 EIC U C1   1 
HETATM 4278 C C2   . EIC I 6 .   ? 129.225 134.468 111.929 1.00 20.00  ? 407 EIC U C2   1 
HETATM 4279 C C3   . EIC I 6 .   ? 127.960 133.878 112.574 1.00 20.00  ? 407 EIC U C3   1 
HETATM 4280 C C4   . EIC I 6 .   ? 128.306 132.805 113.608 1.00 20.00  ? 407 EIC U C4   1 
HETATM 4281 C C5   . EIC I 6 .   ? 127.047 132.402 114.377 1.00 20.00  ? 407 EIC U C5   1 
HETATM 4282 C C6   . EIC I 6 .   ? 127.072 130.912 114.718 1.00 20.00  ? 407 EIC U C6   1 
HETATM 4283 C C7   . EIC I 6 .   ? 126.253 130.627 115.979 1.00 20.00  ? 407 EIC U C7   1 
HETATM 4284 C C8   . EIC I 6 .   ? 127.049 130.942 117.248 1.00 20.00  ? 407 EIC U C8   1 
HETATM 4285 C C9   . EIC I 6 .   ? 126.280 130.460 118.450 1.00 20.00  ? 407 EIC U C9   1 
HETATM 4286 C C10  . EIC I 6 .   ? 126.778 130.043 119.611 1.00 20.00  ? 407 EIC U C10  1 
HETATM 4287 C C11  . EIC I 6 .   ? 128.230 129.951 120.009 1.00 20.00  ? 407 EIC U C11  1 
HETATM 4288 C C12  . EIC I 6 .   ? 128.318 129.404 121.415 1.00 20.00  ? 407 EIC U C12  1 
HETATM 4289 C C13  . EIC I 6 .   ? 128.969 129.918 122.460 1.00 20.00  ? 407 EIC U C13  1 
HETATM 4290 C C14  . EIC I 6 .   ? 129.796 131.183 122.491 1.00 20.00  ? 407 EIC U C14  1 
HETATM 4291 C C15  . EIC I 6 .   ? 130.276 131.487 123.917 1.00 20.00  ? 407 EIC U C15  1 
HETATM 4292 C C16  . EIC I 6 .   ? 130.247 132.988 124.230 1.00 20.00  ? 407 EIC U C16  1 
HETATM 4293 C C17  . EIC I 6 .   ? 131.252 133.769 123.376 1.00 20.00  ? 407 EIC U C17  1 
HETATM 4294 C C18  . EIC I 6 .   ? 131.314 135.237 123.811 1.00 20.00  ? 407 EIC U C18  1 
HETATM 4295 O O1   . EIC I 6 .   ? 127.962 135.404 110.173 1.00 20.00  ? 407 EIC U O1   1 
HETATM 4296 O O2   . EIC I 6 .   ? 129.921 134.693 109.712 1.00 20.00  ? 407 EIC U O2   1 
HETATM 4297 H H21  . EIC I 6 .   ? 129.560 135.343 112.499 1.00 20.00  ? 407 EIC U H21  1 
HETATM 4298 H H22  . EIC I 6 .   ? 130.032 133.725 111.954 1.00 20.00  ? 407 EIC U H22  1 
HETATM 4299 H H31  . EIC I 6 .   ? 127.319 133.444 111.796 1.00 20.00  ? 407 EIC U H31  1 
HETATM 4300 H H32  . EIC I 6 .   ? 127.388 134.683 113.055 1.00 20.00  ? 407 EIC U H32  1 
HETATM 4301 H H41  . EIC I 6 .   ? 129.068 133.191 114.298 1.00 20.00  ? 407 EIC U H41  1 
HETATM 4302 H H42  . EIC I 6 .   ? 128.733 131.930 113.102 1.00 20.00  ? 407 EIC U H42  1 
HETATM 4303 H H51  . EIC I 6 .   ? 126.164 132.635 113.770 1.00 20.00  ? 407 EIC U H51  1 
HETATM 4304 H H52  . EIC I 6 .   ? 126.972 132.994 115.297 1.00 20.00  ? 407 EIC U H52  1 
HETATM 4305 H H61  . EIC I 6 .   ? 128.112 130.591 114.869 1.00 20.00  ? 407 EIC U H61  1 
HETATM 4306 H H62  . EIC I 6 .   ? 126.665 130.336 113.875 1.00 20.00  ? 407 EIC U H62  1 
HETATM 4307 H H71  . EIC I 6 .   ? 125.949 129.572 115.985 1.00 20.00  ? 407 EIC U H71  1 
HETATM 4308 H H72  . EIC I 6 .   ? 125.346 131.240 115.964 1.00 20.00  ? 407 EIC U H72  1 
HETATM 4309 H H81  . EIC I 6 .   ? 127.204 132.024 117.322 1.00 20.00  ? 407 EIC U H81  1 
HETATM 4310 H H82  . EIC I 6 .   ? 128.041 130.487 117.174 1.00 20.00  ? 407 EIC U H82  1 
HETATM 4311 H H91  . EIC I 6 .   ? 125.199 130.468 118.312 1.00 20.00  ? 407 EIC U H91  1 
HETATM 4312 H H1O1 . EIC I 6 .   ? 126.090 129.721 120.394 1.00 20.00  ? 407 EIC U H1O1 1 
HETATM 4313 H H111 . EIC I 6 .   ? 128.721 130.929 119.970 1.00 20.00  ? 407 EIC U H111 1 
HETATM 4314 H H112 . EIC I 6 .   ? 128.745 129.308 119.288 1.00 20.00  ? 407 EIC U H112 1 
HETATM 4315 H H121 . EIC I 6 .   ? 127.763 128.477 121.551 1.00 20.00  ? 407 EIC U H121 1 
HETATM 4316 H H131 . EIC I 6 .   ? 128.927 129.388 123.410 1.00 20.00  ? 407 EIC U H131 1 
HETATM 4317 H H141 . EIC I 6 .   ? 129.236 132.044 122.111 1.00 20.00  ? 407 EIC U H141 1 
HETATM 4318 H H142 . EIC I 6 .   ? 130.667 131.064 121.835 1.00 20.00  ? 407 EIC U H142 1 
HETATM 4319 H H151 . EIC I 6 .   ? 131.295 131.107 124.044 1.00 20.00  ? 407 EIC U H151 1 
HETATM 4320 H H152 . EIC I 6 .   ? 129.637 130.963 124.640 1.00 20.00  ? 407 EIC U H152 1 
HETATM 4321 H H161 . EIC I 6 .   ? 130.489 133.141 125.290 1.00 20.00  ? 407 EIC U H161 1 
HETATM 4322 H H162 . EIC I 6 .   ? 129.235 133.381 124.062 1.00 20.00  ? 407 EIC U H162 1 
HETATM 4323 H H171 . EIC I 6 .   ? 130.964 133.716 122.319 1.00 20.00  ? 407 EIC U H171 1 
HETATM 4324 H H172 . EIC I 6 .   ? 132.248 133.320 123.467 1.00 20.00  ? 407 EIC U H172 1 
HETATM 4325 H H181 . EIC I 6 .   ? 130.935 135.344 124.833 1.00 20.00  ? 407 EIC U H181 1 
HETATM 4326 H H182 . EIC I 6 .   ? 132.345 135.610 123.785 1.00 20.00  ? 407 EIC U H182 1 
HETATM 4327 H H183 . EIC I 6 .   ? 130.701 135.867 123.152 1.00 20.00  ? 407 EIC U H183 1 
HETATM 4328 C C1   . OCT J 4 .   ? 100.407 102.201 109.123 1.00 20.00  ? 408 OCT U C1   1 
HETATM 4329 C C2   . OCT J 4 .   ? 100.476 101.232 110.293 1.00 20.00  ? 408 OCT U C2   1 
HETATM 4330 C C3   . OCT J 4 .   ? 100.962 101.929 111.542 1.00 20.00  ? 408 OCT U C3   1 
HETATM 4331 C C4   . OCT J 4 .   ? 99.820  102.380 112.421 1.00 20.00  ? 408 OCT U C4   1 
HETATM 4332 C C5   . OCT J 4 .   ? 100.284 102.659 113.839 1.00 20.00  ? 408 OCT U C5   1 
HETATM 4333 C C6   . OCT J 4 .   ? 99.841  101.589 114.815 1.00 20.00  ? 408 OCT U C6   1 
HETATM 4334 C C7   . OCT J 4 .   ? 100.053 102.066 116.238 1.00 20.00  ? 408 OCT U C7   1 
HETATM 4335 C C8   . OCT J 4 .   ? 99.546  101.066 117.264 1.00 20.00  ? 408 OCT U C8   1 
HETATM 4336 H H11  . OCT J 4 .   ? 99.873  101.742 108.305 1.00 20.00  ? 408 OCT U H11  1 
HETATM 4337 H H12  . OCT J 4 .   ? 99.890  103.098 109.440 1.00 20.00  ? 408 OCT U H12  1 
HETATM 4338 H H13  . OCT J 4 .   ? 101.412 102.455 108.810 1.00 20.00  ? 408 OCT U H13  1 
HETATM 4339 H H21  . OCT J 4 .   ? 101.160 100.430 110.047 1.00 20.00  ? 408 OCT U H21  1 
HETATM 4340 H H22  . OCT J 4 .   ? 99.492  100.824 110.472 1.00 20.00  ? 408 OCT U H22  1 
HETATM 4341 H H31  . OCT J 4 .   ? 101.587 101.250 112.109 1.00 20.00  ? 408 OCT U H31  1 
HETATM 4342 H H32  . OCT J 4 .   ? 101.544 102.795 111.255 1.00 20.00  ? 408 OCT U H32  1 
HETATM 4343 H H41  . OCT J 4 .   ? 99.389  103.280 112.001 1.00 20.00  ? 408 OCT U H41  1 
HETATM 4344 H H42  . OCT J 4 .   ? 99.068  101.603 112.450 1.00 20.00  ? 408 OCT U H42  1 
HETATM 4345 H H51  . OCT J 4 .   ? 99.880  103.609 114.163 1.00 20.00  ? 408 OCT U H51  1 
HETATM 4346 H H52  . OCT J 4 .   ? 101.364 102.713 113.847 1.00 20.00  ? 408 OCT U H52  1 
HETATM 4347 H H61  . OCT J 4 .   ? 98.791  101.374 114.664 1.00 20.00  ? 408 OCT U H61  1 
HETATM 4348 H H62  . OCT J 4 .   ? 100.423 100.690 114.646 1.00 20.00  ? 408 OCT U H62  1 
HETATM 4349 H H71  . OCT J 4 .   ? 101.110 102.226 116.394 1.00 20.00  ? 408 OCT U H71  1 
HETATM 4350 H H72  . OCT J 4 .   ? 99.529  103.002 116.369 1.00 20.00  ? 408 OCT U H72  1 
HETATM 4351 H H81  . OCT J 4 .   ? 98.694  101.485 117.788 1.00 20.00  ? 408 OCT U H81  1 
HETATM 4352 H H82  . OCT J 4 .   ? 99.246  100.161 116.752 1.00 20.00  ? 408 OCT U H82  1 
HETATM 4353 H H83  . OCT J 4 .   ? 100.333 100.840 117.971 1.00 20.00  ? 408 OCT U H83  1 
HETATM 4354 C C1   . OCT K 4 .   ? 110.217 101.816 128.039 1.00 20.00  ? 409 OCT U C1   1 
HETATM 4355 C C2   . OCT K 4 .   ? 109.631 101.280 129.338 1.00 20.00  ? 409 OCT U C2   1 
HETATM 4356 C C3   . OCT K 4 .   ? 109.878 99.788  129.441 1.00 20.00  ? 409 OCT U C3   1 
HETATM 4357 C C4   . OCT K 4 .   ? 108.945 99.082  130.408 1.00 20.00  ? 409 OCT U C4   1 
HETATM 4358 C C5   . OCT K 4 .   ? 109.511 98.990  131.813 1.00 20.00  ? 409 OCT U C5   1 
HETATM 4359 C C6   . OCT K 4 .   ? 108.442 99.260  132.854 1.00 20.00  ? 409 OCT U C6   1 
HETATM 4360 C C7   . OCT K 4 .   ? 108.849 98.766  134.228 1.00 20.00  ? 409 OCT U C7   1 
HETATM 4361 C C8   . OCT K 4 .   ? 108.303 97.386  134.534 1.00 20.00  ? 409 OCT U C8   1 
HETATM 4362 H H11  . OCT K 4 .   ? 110.289 102.896 128.093 1.00 20.00  ? 409 OCT U H11  1 
HETATM 4363 H H12  . OCT K 4 .   ? 111.199 101.387 127.894 1.00 20.00  ? 409 OCT U H12  1 
HETATM 4364 H H13  . OCT K 4 .   ? 109.572 101.531 127.218 1.00 20.00  ? 409 OCT U H13  1 
HETATM 4365 H H21  . OCT K 4 .   ? 108.567 101.469 129.357 1.00 20.00  ? 409 OCT U H21  1 
HETATM 4366 H H22  . OCT K 4 .   ? 110.102 101.775 130.178 1.00 20.00  ? 409 OCT U H22  1 
HETATM 4367 H H31  . OCT K 4 .   ? 109.755 99.356  128.459 1.00 20.00  ? 409 OCT U H31  1 
HETATM 4368 H H32  . OCT K 4 .   ? 110.899 99.629  129.768 1.00 20.00  ? 409 OCT U H32  1 
HETATM 4369 H H41  . OCT K 4 .   ? 108.012 99.629  130.451 1.00 20.00  ? 409 OCT U H41  1 
HETATM 4370 H H42  . OCT K 4 .   ? 108.754 98.082  130.043 1.00 20.00  ? 409 OCT U H42  1 
HETATM 4371 H H51  . OCT K 4 .   ? 110.300 99.720  131.925 1.00 20.00  ? 409 OCT U H51  1 
HETATM 4372 H H52  . OCT K 4 .   ? 109.910 98.000  131.972 1.00 20.00  ? 409 OCT U H52  1 
HETATM 4373 H H61  . OCT K 4 .   ? 108.259 100.326 132.897 1.00 20.00  ? 409 OCT U H61  1 
HETATM 4374 H H62  . OCT K 4 .   ? 107.531 98.753  132.560 1.00 20.00  ? 409 OCT U H62  1 
HETATM 4375 H H71  . OCT K 4 .   ? 109.926 98.729  134.271 1.00 20.00  ? 409 OCT U H71  1 
HETATM 4376 H H72  . OCT K 4 .   ? 108.483 99.457  134.975 1.00 20.00  ? 409 OCT U H72  1 
HETATM 4377 H H81  . OCT K 4 .   ? 108.508 96.734  133.693 1.00 20.00  ? 409 OCT U H81  1 
HETATM 4378 H H82  . OCT K 4 .   ? 108.781 96.997  135.424 1.00 20.00  ? 409 OCT U H82  1 
HETATM 4379 H H83  . OCT K 4 .   ? 107.235 97.452  134.690 1.00 20.00  ? 409 OCT U H83  1 
HETATM 4380 K K    . K   L 7 .   ? 120.240 120.257 118.789 1.00 52.23  ? 410 K   U K    1 
HETATM 4381 C C1   . OCT M 4 .   ? 123.918 140.224 129.017 1.00 20.00  ? 401 OCT A C1   1 
HETATM 4382 C C2   . OCT M 4 .   ? 123.709 139.844 130.470 1.00 20.00  ? 401 OCT A C2   1 
HETATM 4383 C C3   . OCT M 4 .   ? 124.920 140.237 131.280 1.00 20.00  ? 401 OCT A C3   1 
HETATM 4384 C C4   . OCT M 4 .   ? 124.768 139.842 132.734 1.00 20.00  ? 401 OCT A C4   1 
HETATM 4385 C C5   . OCT M 4 .   ? 126.034 140.253 133.455 1.00 20.00  ? 401 OCT A C5   1 
HETATM 4386 C C6   . OCT M 4 .   ? 125.939 140.078 134.949 1.00 20.00  ? 401 OCT A C6   1 
HETATM 4387 C C7   . OCT M 4 .   ? 126.988 140.947 135.622 1.00 20.00  ? 401 OCT A C7   1 
HETATM 4388 C C8   . OCT M 4 .   ? 126.702 141.111 137.105 1.00 20.00  ? 401 OCT A C8   1 
HETATM 4389 H H11  . OCT M 4 .   ? 122.957 140.326 128.528 1.00 20.00  ? 401 OCT A H11  1 
HETATM 4390 H H12  . OCT M 4 .   ? 124.453 141.164 128.974 1.00 20.00  ? 401 OCT A H12  1 
HETATM 4391 H H13  . OCT M 4 .   ? 124.498 139.454 128.527 1.00 20.00  ? 401 OCT A H13  1 
HETATM 4392 H H21  . OCT M 4 .   ? 123.560 138.775 130.546 1.00 20.00  ? 401 OCT A H21  1 
HETATM 4393 H H22  . OCT M 4 .   ? 122.840 140.361 130.857 1.00 20.00  ? 401 OCT A H22  1 
HETATM 4394 H H31  . OCT M 4 .   ? 125.791 139.744 130.872 1.00 20.00  ? 401 OCT A H31  1 
HETATM 4395 H H32  . OCT M 4 .   ? 125.056 141.308 131.216 1.00 20.00  ? 401 OCT A H32  1 
HETATM 4396 H H41  . OCT M 4 .   ? 123.921 140.359 133.166 1.00 20.00  ? 401 OCT A H41  1 
HETATM 4397 H H42  . OCT M 4 .   ? 124.633 138.773 132.812 1.00 20.00  ? 401 OCT A H42  1 
HETATM 4398 H H51  . OCT M 4 .   ? 126.230 141.293 133.234 1.00 20.00  ? 401 OCT A H51  1 
HETATM 4399 H H52  . OCT M 4 .   ? 126.853 139.653 133.084 1.00 20.00  ? 401 OCT A H52  1 
HETATM 4400 H H61  . OCT M 4 .   ? 124.955 140.380 135.283 1.00 20.00  ? 401 OCT A H61  1 
HETATM 4401 H H62  . OCT M 4 .   ? 126.109 139.041 135.204 1.00 20.00  ? 401 OCT A H62  1 
HETATM 4402 H H71  . OCT M 4 .   ? 127.957 140.484 135.496 1.00 20.00  ? 401 OCT A H71  1 
HETATM 4403 H H72  . OCT M 4 .   ? 126.993 141.921 135.158 1.00 20.00  ? 401 OCT A H72  1 
HETATM 4404 H H81  . OCT M 4 .   ? 125.773 141.654 137.227 1.00 20.00  ? 401 OCT A H81  1 
HETATM 4405 H H82  . OCT M 4 .   ? 126.613 140.133 137.559 1.00 20.00  ? 401 OCT A H82  1 
HETATM 4406 H H83  . OCT M 4 .   ? 127.512 141.660 137.568 1.00 20.00  ? 401 OCT A H83  1 
HETATM 4407 C C1   . D12 N 2 .   ? 106.623 101.217 111.966 1.00 20.00  ? 402 D12 A C1   1 
HETATM 4408 C C2   . D12 N 2 .   ? 106.099 101.898 113.204 1.00 20.00  ? 402 D12 A C2   1 
HETATM 4409 C C3   . D12 N 2 .   ? 105.611 103.302 112.905 1.00 20.00  ? 402 D12 A C3   1 
HETATM 4410 C C4   . D12 N 2 .   ? 104.557 103.729 113.894 1.00 20.00  ? 402 D12 A C4   1 
HETATM 4411 C C5   . D12 N 2 .   ? 105.131 104.044 115.253 1.00 20.00  ? 402 D12 A C5   1 
HETATM 4412 C C6   . D12 N 2 .   ? 104.536 103.267 116.401 1.00 20.00  ? 402 D12 A C6   1 
HETATM 4413 C C7   . D12 N 2 .   ? 105.132 101.887 116.566 1.00 20.00  ? 402 D12 A C7   1 
HETATM 4414 C C8   . D12 N 2 .   ? 106.539 101.862 117.121 1.00 20.00  ? 402 D12 A C8   1 
HETATM 4415 C C9   . D12 N 2 .   ? 106.655 102.467 118.501 1.00 20.00  ? 402 D12 A C9   1 
HETATM 4416 C C10  . D12 N 2 .   ? 105.557 102.033 119.450 1.00 20.00  ? 402 D12 A C10  1 
HETATM 4417 C C11  . D12 N 2 .   ? 106.085 101.974 120.857 1.00 20.00  ? 402 D12 A C11  1 
HETATM 4418 C C12  . D12 N 2 .   ? 104.951 101.802 121.837 1.00 20.00  ? 402 D12 A C12  1 
HETATM 4419 H H11  . D12 N 2 .   ? 105.788 100.972 111.315 1.00 20.00  ? 402 D12 A H11  1 
HETATM 4420 H H12  . D12 N 2 .   ? 107.147 100.310 112.248 1.00 20.00  ? 402 D12 A H12  1 
HETATM 4421 H H13  . D12 N 2 .   ? 107.300 101.889 111.450 1.00 20.00  ? 402 D12 A H13  1 
HETATM 4422 H H21  . D12 N 2 .   ? 106.874 101.940 113.961 1.00 20.00  ? 402 D12 A H21  1 
HETATM 4423 H H22  . D12 N 2 .   ? 105.264 101.318 113.570 1.00 20.00  ? 402 D12 A H22  1 
HETATM 4424 H H31  . D12 N 2 .   ? 105.196 103.319 111.905 1.00 20.00  ? 402 D12 A H31  1 
HETATM 4425 H H32  . D12 N 2 .   ? 106.449 103.986 112.962 1.00 20.00  ? 402 D12 A H32  1 
HETATM 4426 H H41  . D12 N 2 .   ? 103.835 102.925 114.001 1.00 20.00  ? 402 D12 A H41  1 
HETATM 4427 H H42  . D12 N 2 .   ? 104.051 104.609 113.510 1.00 20.00  ? 402 D12 A H42  1 
HETATM 4428 H H51  . D12 N 2 .   ? 106.199 103.872 115.220 1.00 20.00  ? 402 D12 A H51  1 
HETATM 4429 H H52  . D12 N 2 .   ? 104.969 105.099 115.448 1.00 20.00  ? 402 D12 A H52  1 
HETATM 4430 H H61  . D12 N 2 .   ? 104.658 103.843 117.311 1.00 20.00  ? 402 D12 A H61  1 
HETATM 4431 H H62  . D12 N 2 .   ? 103.477 103.151 116.211 1.00 20.00  ? 402 D12 A H62  1 
HETATM 4432 H H71  . D12 N 2 .   ? 104.468 101.302 117.189 1.00 20.00  ? 402 D12 A H71  1 
HETATM 4433 H H72  . D12 N 2 .   ? 105.149 101.399 115.608 1.00 20.00  ? 402 D12 A H72  1 
HETATM 4434 H H81  . D12 N 2 .   ? 107.195 102.397 116.446 1.00 20.00  ? 402 D12 A H81  1 
HETATM 4435 H H82  . D12 N 2 .   ? 106.861 100.829 117.177 1.00 20.00  ? 402 D12 A H82  1 
HETATM 4436 H H91  . D12 N 2 .   ? 106.631 103.545 118.411 1.00 20.00  ? 402 D12 A H91  1 
HETATM 4437 H H92  . D12 N 2 .   ? 107.606 102.174 118.927 1.00 20.00  ? 402 D12 A H92  1 
HETATM 4438 H H101 . D12 N 2 .   ? 104.731 102.737 119.404 1.00 20.00  ? 402 D12 A H101 1 
HETATM 4439 H H102 . D12 N 2 .   ? 105.211 101.042 119.185 1.00 20.00  ? 402 D12 A H102 1 
HETATM 4440 H H111 . D12 N 2 .   ? 106.615 102.894 121.073 1.00 20.00  ? 402 D12 A H111 1 
HETATM 4441 H H112 . D12 N 2 .   ? 106.765 101.134 120.943 1.00 20.00  ? 402 D12 A H112 1 
HETATM 4442 H H121 . D12 N 2 .   ? 105.290 101.219 122.685 1.00 20.00  ? 402 D12 A H121 1 
HETATM 4443 H H122 . D12 N 2 .   ? 104.618 102.780 122.172 1.00 20.00  ? 402 D12 A H122 1 
HETATM 4444 H H123 . D12 N 2 .   ? 104.132 101.291 121.341 1.00 20.00  ? 402 D12 A H123 1 
HETATM 4445 C C1   . D10 O 3 .   ? 117.725 92.542  107.681 1.00 20.00  ? 403 D10 A C1   1 
HETATM 4446 C C2   . D10 O 3 .   ? 117.419 93.800  108.479 1.00 20.00  ? 403 D10 A C2   1 
HETATM 4447 C C3   . D10 O 3 .   ? 117.570 93.591  109.979 1.00 20.00  ? 403 D10 A C3   1 
HETATM 4448 C C4   . D10 O 3 .   ? 116.632 94.488  110.766 1.00 20.00  ? 403 D10 A C4   1 
HETATM 4449 C C5   . D10 O 3 .   ? 116.357 93.907  112.135 1.00 20.00  ? 403 D10 A C5   1 
HETATM 4450 C C6   . D10 O 3 .   ? 117.516 94.168  113.081 1.00 20.00  ? 403 D10 A C6   1 
HETATM 4451 C C7   . D10 O 3 .   ? 117.297 93.583  114.467 1.00 20.00  ? 403 D10 A C7   1 
HETATM 4452 C C8   . D10 O 3 .   ? 116.002 94.040  115.114 1.00 20.00  ? 403 D10 A C8   1 
HETATM 4453 C C9   . D10 O 3 .   ? 116.141 94.148  116.622 1.00 20.00  ? 403 D10 A C9   1 
HETATM 4454 C C10  . D10 O 3 .   ? 116.527 95.560  117.033 1.00 20.00  ? 403 D10 A C10  1 
HETATM 4455 H H11  . D10 O 3 .   ? 118.727 92.612  107.275 1.00 20.00  ? 403 D10 A H11  1 
HETATM 4456 H H12  . D10 O 3 .   ? 117.657 91.676  108.326 1.00 20.00  ? 403 D10 A H12  1 
HETATM 4457 H H13  . D10 O 3 .   ? 117.013 92.449  106.871 1.00 20.00  ? 403 D10 A H13  1 
HETATM 4458 H H21  . D10 O 3 .   ? 116.404 94.110  108.267 1.00 20.00  ? 403 D10 A H21  1 
HETATM 4459 H H22  . D10 O 3 .   ? 118.097 94.584  108.168 1.00 20.00  ? 403 D10 A H22  1 
HETATM 4460 H H31  . D10 O 3 .   ? 118.591 93.813  110.264 1.00 20.00  ? 403 D10 A H31  1 
HETATM 4461 H H32  . D10 O 3 .   ? 117.352 92.559  110.221 1.00 20.00  ? 403 D10 A H32  1 
HETATM 4462 H H41  . D10 O 3 .   ? 115.696 94.593  110.232 1.00 20.00  ? 403 D10 A H41  1 
HETATM 4463 H H42  . D10 O 3 .   ? 117.089 95.463  110.882 1.00 20.00  ? 403 D10 A H42  1 
HETATM 4464 H H51  . D10 O 3 .   ? 115.459 94.371  112.524 1.00 20.00  ? 403 D10 A H51  1 
HETATM 4465 H H52  . D10 O 3 .   ? 116.200 92.840  112.049 1.00 20.00  ? 403 D10 A H52  1 
HETATM 4466 H H61  . D10 O 3 .   ? 118.416 93.737  112.661 1.00 20.00  ? 403 D10 A H61  1 
HETATM 4467 H H62  . D10 O 3 .   ? 117.651 95.238  113.174 1.00 20.00  ? 403 D10 A H62  1 
HETATM 4468 H H71  . D10 O 3 .   ? 117.282 92.504  114.387 1.00 20.00  ? 403 D10 A H71  1 
HETATM 4469 H H72  . D10 O 3 .   ? 118.125 93.876  115.100 1.00 20.00  ? 403 D10 A H72  1 
HETATM 4470 H H81  . D10 O 3 .   ? 115.219 93.331  114.880 1.00 20.00  ? 403 D10 A H81  1 
HETATM 4471 H H82  . D10 O 3 .   ? 115.733 95.011  114.719 1.00 20.00  ? 403 D10 A H82  1 
HETATM 4472 H H91  . D10 O 3 .   ? 116.906 93.459  116.957 1.00 20.00  ? 403 D10 A H91  1 
HETATM 4473 H H92  . D10 O 3 .   ? 115.197 93.890  117.084 1.00 20.00  ? 403 D10 A H92  1 
HETATM 4474 H H101 . D10 O 3 .   ? 115.721 96.238  116.778 1.00 20.00  ? 403 D10 A H101 1 
HETATM 4475 H H102 . D10 O 3 .   ? 117.425 95.853  116.504 1.00 20.00  ? 403 D10 A H102 1 
HETATM 4476 H H103 . D10 O 3 .   ? 116.705 95.592  118.101 1.00 20.00  ? 403 D10 A H103 1 
HETATM 4477 C C1   . OCT P 4 .   ? 117.020 100.482 129.192 1.00 20.00  ? 404 OCT A C1   1 
HETATM 4478 C C2   . OCT P 4 .   ? 115.868 100.277 130.156 1.00 20.00  ? 404 OCT A C2   1 
HETATM 4479 C C3   . OCT P 4 .   ? 116.227 100.782 131.535 1.00 20.00  ? 404 OCT A C3   1 
HETATM 4480 C C4   . OCT P 4 .   ? 115.321 100.105 132.535 1.00 20.00  ? 404 OCT A C4   1 
HETATM 4481 C C5   . OCT P 4 .   ? 115.412 100.726 133.911 1.00 20.00  ? 404 OCT A C5   1 
HETATM 4482 C C6   . OCT P 4 .   ? 114.138 100.403 134.655 1.00 20.00  ? 404 OCT A C6   1 
HETATM 4483 C C7   . OCT P 4 .   ? 114.380 100.132 136.128 1.00 20.00  ? 404 OCT A C7   1 
HETATM 4484 C C8   . OCT P 4 .   ? 113.365 99.140  136.665 1.00 20.00  ? 404 OCT A C8   1 
HETATM 4485 H H11  . OCT P 4 .   ? 116.697 100.233 128.191 1.00 20.00  ? 404 OCT A H11  1 
HETATM 4486 H H12  . OCT P 4 .   ? 117.332 101.518 129.232 1.00 20.00  ? 404 OCT A H12  1 
HETATM 4487 H H13  . OCT P 4 .   ? 117.842 99.843  129.481 1.00 20.00  ? 404 OCT A H13  1 
HETATM 4488 H H21  . OCT P 4 .   ? 115.640 99.222  130.221 1.00 20.00  ? 404 OCT A H21  1 
HETATM 4489 H H22  . OCT P 4 .   ? 115.000 100.812 129.797 1.00 20.00  ? 404 OCT A H22  1 
HETATM 4490 H H31  . OCT P 4 .   ? 117.260 100.542 131.751 1.00 20.00  ? 404 OCT A H31  1 
HETATM 4491 H H32  . OCT P 4 .   ? 116.083 101.854 131.579 1.00 20.00  ? 404 OCT A H32  1 
HETATM 4492 H H41  . OCT P 4 .   ? 114.302 100.184 132.184 1.00 20.00  ? 404 OCT A H41  1 
HETATM 4493 H H42  . OCT P 4 .   ? 115.592 99.060  132.605 1.00 20.00  ? 404 OCT A H42  1 
HETATM 4494 H H51  . OCT P 4 .   ? 115.519 101.798 133.815 1.00 20.00  ? 404 OCT A H51  1 
HETATM 4495 H H52  . OCT P 4 .   ? 116.268 100.318 134.434 1.00 20.00  ? 404 OCT A H52  1 
HETATM 4496 H H61  . OCT P 4 .   ? 113.452 101.234 134.558 1.00 20.00  ? 404 OCT A H61  1 
HETATM 4497 H H62  . OCT P 4 .   ? 113.692 99.523  134.215 1.00 20.00  ? 404 OCT A H62  1 
HETATM 4498 H H71  . OCT P 4 .   ? 115.372 99.722  136.261 1.00 20.00  ? 404 OCT A H71  1 
HETATM 4499 H H72  . OCT P 4 .   ? 114.296 101.060 136.678 1.00 20.00  ? 404 OCT A H72  1 
HETATM 4500 H H81  . OCT P 4 .   ? 112.376 99.430  136.323 1.00 20.00  ? 404 OCT A H81  1 
HETATM 4501 H H82  . OCT P 4 .   ? 113.601 98.153  136.291 1.00 20.00  ? 404 OCT A H82  1 
HETATM 4502 H H83  . OCT P 4 .   ? 113.394 99.142  137.745 1.00 20.00  ? 404 OCT A H83  1 
HETATM 4503 C C1   . OCT Q 4 .   ? 104.990 95.347  110.837 1.00 20.00  ? 405 OCT A C1   1 
HETATM 4504 C C2   . OCT Q 4 .   ? 105.576 94.746  112.099 1.00 20.00  ? 405 OCT A C2   1 
HETATM 4505 C C3   . OCT Q 4 .   ? 105.534 95.725  113.253 1.00 20.00  ? 405 OCT A C3   1 
HETATM 4506 C C4   . OCT Q 4 .   ? 106.646 95.383  114.217 1.00 20.00  ? 405 OCT A C4   1 
HETATM 4507 C C5   . OCT Q 4 .   ? 106.602 96.295  115.420 1.00 20.00  ? 405 OCT A C5   1 
HETATM 4508 C C6   . OCT Q 4 .   ? 105.733 95.758  116.540 1.00 20.00  ? 405 OCT A C6   1 
HETATM 4509 C C7   . OCT Q 4 .   ? 106.507 95.741  117.842 1.00 20.00  ? 405 OCT A C7   1 
HETATM 4510 C C8   . OCT Q 4 .   ? 105.576 95.853  119.034 1.00 20.00  ? 405 OCT A C8   1 
HETATM 4511 H H11  . OCT Q 4 .   ? 104.054 95.832  111.080 1.00 20.00  ? 405 OCT A H11  1 
HETATM 4512 H H12  . OCT Q 4 .   ? 105.683 96.076  110.435 1.00 20.00  ? 405 OCT A H12  1 
HETATM 4513 H H13  . OCT Q 4 .   ? 104.818 94.563  110.110 1.00 20.00  ? 405 OCT A H13  1 
HETATM 4514 H H21  . OCT Q 4 .   ? 106.606 94.472  111.914 1.00 20.00  ? 405 OCT A H21  1 
HETATM 4515 H H22  . OCT Q 4 .   ? 105.014 93.863  112.365 1.00 20.00  ? 405 OCT A H22  1 
HETATM 4516 H H31  . OCT Q 4 .   ? 105.672 96.728  112.878 1.00 20.00  ? 405 OCT A H31  1 
HETATM 4517 H H32  . OCT Q 4 .   ? 104.581 95.647  113.761 1.00 20.00  ? 405 OCT A H32  1 
HETATM 4518 H H41  . OCT Q 4 .   ? 106.539 94.355  114.532 1.00 20.00  ? 405 OCT A H41  1 
HETATM 4519 H H42  . OCT Q 4 .   ? 107.595 95.507  113.713 1.00 20.00  ? 405 OCT A H42  1 
HETATM 4520 H H51  . OCT Q 4 .   ? 106.210 97.255  115.106 1.00 20.00  ? 405 OCT A H51  1 
HETATM 4521 H H52  . OCT Q 4 .   ? 107.609 96.424  115.788 1.00 20.00  ? 405 OCT A H52  1 
HETATM 4522 H H61  . OCT Q 4 .   ? 104.866 96.394  116.655 1.00 20.00  ? 405 OCT A H61  1 
HETATM 4523 H H62  . OCT Q 4 .   ? 105.411 94.755  116.301 1.00 20.00  ? 405 OCT A H62  1 
HETATM 4524 H H71  . OCT Q 4 .   ? 107.065 94.815  117.909 1.00 20.00  ? 405 OCT A H71  1 
HETATM 4525 H H72  . OCT Q 4 .   ? 107.193 96.578  117.861 1.00 20.00  ? 405 OCT A H72  1 
HETATM 4526 H H81  . OCT Q 4 .   ? 104.635 95.375  118.792 1.00 20.00  ? 405 OCT A H81  1 
HETATM 4527 H H82  . OCT Q 4 .   ? 106.024 95.364  119.890 1.00 20.00  ? 405 OCT A H82  1 
HETATM 4528 H H83  . OCT Q 4 .   ? 105.404 96.898  119.256 1.00 20.00  ? 405 OCT A H83  1 
HETATM 4529 C C1   . D10 R 3 .   ? 122.590 92.512  107.429 1.00 20.00  ? 406 D10 A C1   1 
HETATM 4530 C C2   . D10 R 3 .   ? 122.601 93.410  108.659 1.00 20.00  ? 406 D10 A C2   1 
HETATM 4531 C C3   . D10 R 3 .   ? 123.179 92.701  109.872 1.00 20.00  ? 406 D10 A C3   1 
HETATM 4532 C C4   . D10 R 3 .   ? 122.396 93.057  111.117 1.00 20.00  ? 406 D10 A C4   1 
HETATM 4533 C C5   . D10 R 3 .   ? 123.206 92.835  112.375 1.00 20.00  ? 406 D10 A C5   1 
HETATM 4534 C C6   . D10 R 3 .   ? 122.524 93.489  113.557 1.00 20.00  ? 406 D10 A C6   1 
HETATM 4535 C C7   . D10 R 3 .   ? 123.425 93.475  114.772 1.00 20.00  ? 406 D10 A C7   1 
HETATM 4536 C C8   . D10 R 3 .   ? 122.784 94.243  115.913 1.00 20.00  ? 406 D10 A C8   1 
HETATM 4537 C C9   . D10 R 3 .   ? 122.021 93.324  116.852 1.00 20.00  ? 406 D10 A C9   1 
HETATM 4538 C C10  . D10 R 3 .   ? 122.914 92.781  117.959 1.00 20.00  ? 406 D10 A C10  1 
HETATM 4539 H H11  . D10 R 3 .   ? 122.152 93.049  106.597 1.00 20.00  ? 406 D10 A H11  1 
HETATM 4540 H H12  . D10 R 3 .   ? 123.607 92.231  107.183 1.00 20.00  ? 406 D10 A H12  1 
HETATM 4541 H H13  . D10 R 3 .   ? 122.007 91.624  107.637 1.00 20.00  ? 406 D10 A H13  1 
HETATM 4542 H H21  . D10 R 3 .   ? 121.586 93.716  108.881 1.00 20.00  ? 406 D10 A H21  1 
HETATM 4543 H H22  . D10 R 3 .   ? 123.197 94.290  108.448 1.00 20.00  ? 406 D10 A H22  1 
HETATM 4544 H H31  . D10 R 3 .   ? 124.210 93.004  110.003 1.00 20.00  ? 406 D10 A H31  1 
HETATM 4545 H H32  . D10 R 3 .   ? 123.135 91.632  109.714 1.00 20.00  ? 406 D10 A H32  1 
HETATM 4546 H H41  . D10 R 3 .   ? 121.503 92.446  111.160 1.00 20.00  ? 406 D10 A H41  1 
HETATM 4547 H H42  . D10 R 3 .   ? 122.110 94.099  111.064 1.00 20.00  ? 406 D10 A H42  1 
HETATM 4548 H H51  . D10 R 3 .   ? 123.303 91.773  112.558 1.00 20.00  ? 406 D10 A H51  1 
HETATM 4549 H H52  . D10 R 3 .   ? 124.189 93.271  112.247 1.00 20.00  ? 406 D10 A H52  1 
HETATM 4550 H H61  . D10 R 3 .   ? 122.285 94.514  113.305 1.00 20.00  ? 406 D10 A H61  1 
HETATM 4551 H H62  . D10 R 3 .   ? 121.610 92.954  113.783 1.00 20.00  ? 406 D10 A H62  1 
HETATM 4552 H H71  . D10 R 3 .   ? 123.594 92.452  115.079 1.00 20.00  ? 406 D10 A H71  1 
HETATM 4553 H H72  . D10 R 3 .   ? 124.371 93.937  114.518 1.00 20.00  ? 406 D10 A H72  1 
HETATM 4554 H H81  . D10 R 3 .   ? 122.099 94.975  115.503 1.00 20.00  ? 406 D10 A H81  1 
HETATM 4555 H H82  . D10 R 3 .   ? 123.556 94.755  116.474 1.00 20.00  ? 406 D10 A H82  1 
HETATM 4556 H H91  . D10 R 3 .   ? 121.622 92.495  116.282 1.00 20.00  ? 406 D10 A H91  1 
HETATM 4557 H H92  . D10 R 3 .   ? 121.203 93.876  117.297 1.00 20.00  ? 406 D10 A H92  1 
HETATM 4558 H H101 . D10 R 3 .   ? 123.317 93.607  118.532 1.00 20.00  ? 406 D10 A H101 1 
HETATM 4559 H H102 . D10 R 3 .   ? 123.726 92.217  117.518 1.00 20.00  ? 406 D10 A H102 1 
HETATM 4560 H H103 . D10 R 3 .   ? 122.334 92.137  118.607 1.00 20.00  ? 406 D10 A H103 1 
HETATM 4561 C C1   . OCT S 4 .   ? 129.939 138.285 127.474 1.00 20.00  ? 407 OCT A C1   1 
HETATM 4562 C C2   . OCT S 4 .   ? 130.451 139.590 128.039 1.00 20.00  ? 407 OCT A C2   1 
HETATM 4563 C C3   . OCT S 4 .   ? 130.938 139.417 129.464 1.00 20.00  ? 407 OCT A C3   1 
HETATM 4564 C C4   . OCT S 4 .   ? 131.032 140.752 130.182 1.00 20.00  ? 407 OCT A C4   1 
HETATM 4565 C C5   . OCT S 4 .   ? 131.426 140.539 131.634 1.00 20.00  ? 407 OCT A C5   1 
HETATM 4566 C C6   . OCT S 4 .   ? 131.441 141.831 132.424 1.00 20.00  ? 407 OCT A C6   1 
HETATM 4567 C C7   . OCT S 4 .   ? 132.174 141.654 133.740 1.00 20.00  ? 407 OCT A C7   1 
HETATM 4568 C C8   . OCT S 4 .   ? 132.042 142.882 134.629 1.00 20.00  ? 407 OCT A C8   1 
HETATM 4569 H H11  . OCT S 4 .   ? 129.832 138.375 126.400 1.00 20.00  ? 407 OCT A H11  1 
HETATM 4570 H H12  . OCT S 4 .   ? 130.647 137.498 127.707 1.00 20.00  ? 407 OCT A H12  1 
HETATM 4571 H H13  . OCT S 4 .   ? 128.982 138.055 127.921 1.00 20.00  ? 407 OCT A H13  1 
HETATM 4572 H H21  . OCT S 4 .   ? 129.652 140.321 128.031 1.00 20.00  ? 407 OCT A H21  1 
HETATM 4573 H H22  . OCT S 4 .   ? 131.269 139.946 127.430 1.00 20.00  ? 407 OCT A H22  1 
HETATM 4574 H H31  . OCT S 4 .   ? 130.248 138.779 129.996 1.00 20.00  ? 407 OCT A H31  1 
HETATM 4575 H H32  . OCT S 4 .   ? 131.916 138.954 129.452 1.00 20.00  ? 407 OCT A H32  1 
HETATM 4576 H H41  . OCT S 4 .   ? 131.778 141.367 129.699 1.00 20.00  ? 407 OCT A H41  1 
HETATM 4577 H H42  . OCT S 4 .   ? 130.072 141.247 130.143 1.00 20.00  ? 407 OCT A H42  1 
HETATM 4578 H H51  . OCT S 4 .   ? 132.412 140.098 131.669 1.00 20.00  ? 407 OCT A H51  1 
HETATM 4579 H H52  . OCT S 4 .   ? 130.719 139.858 132.089 1.00 20.00  ? 407 OCT A H52  1 
HETATM 4580 H H61  . OCT S 4 .   ? 131.936 142.594 131.839 1.00 20.00  ? 407 OCT A H61  1 
HETATM 4581 H H62  . OCT S 4 .   ? 130.421 142.135 132.621 1.00 20.00  ? 407 OCT A H62  1 
HETATM 4582 H H71  . OCT S 4 .   ? 131.762 140.798 134.254 1.00 20.00  ? 407 OCT A H71  1 
HETATM 4583 H H72  . OCT S 4 .   ? 133.222 141.478 133.533 1.00 20.00  ? 407 OCT A H72  1 
HETATM 4584 H H81  . OCT S 4 .   ? 131.857 142.570 135.649 1.00 20.00  ? 407 OCT A H81  1 
HETATM 4585 H H82  . OCT S 4 .   ? 132.954 143.459 134.584 1.00 20.00  ? 407 OCT A H82  1 
HETATM 4586 H H83  . OCT S 4 .   ? 131.215 143.486 134.276 1.00 20.00  ? 407 OCT A H83  1 
HETATM 4587 C C1   . HEX T 5 .   ? 144.484 133.660 112.938 1.00 20.00  ? 408 HEX A C1   1 
HETATM 4588 C C2   . HEX T 5 .   ? 145.102 132.321 113.321 1.00 20.00  ? 408 HEX A C2   1 
HETATM 4589 C C3   . HEX T 5 .   ? 145.799 132.395 114.668 1.00 20.00  ? 408 HEX A C3   1 
HETATM 4590 C C4   . HEX T 5 .   ? 144.806 132.615 115.798 1.00 20.00  ? 408 HEX A C4   1 
HETATM 4591 C C5   . HEX T 5 .   ? 145.389 132.176 117.131 1.00 20.00  ? 408 HEX A C5   1 
HETATM 4592 C C6   . HEX T 5 .   ? 145.149 130.694 117.385 1.00 20.00  ? 408 HEX A C6   1 
HETATM 4593 H H11  . HEX T 5 .   ? 143.465 133.698 113.301 1.00 20.00  ? 408 HEX A H11  1 
HETATM 4594 H H12  . HEX T 5 .   ? 144.498 133.770 111.863 1.00 20.00  ? 408 HEX A H12  1 
HETATM 4595 H H13  . HEX T 5 .   ? 145.060 134.458 113.394 1.00 20.00  ? 408 HEX A H13  1 
HETATM 4596 H H21  . HEX T 5 .   ? 145.821 132.033 112.566 1.00 20.00  ? 408 HEX A H21  1 
HETATM 4597 H H22  . HEX T 5 .   ? 144.320 131.575 113.376 1.00 20.00  ? 408 HEX A H22  1 
HETATM 4598 H H31  . HEX T 5 .   ? 146.505 133.215 114.658 1.00 20.00  ? 408 HEX A H31  1 
HETATM 4599 H H32  . HEX T 5 .   ? 146.333 131.468 114.840 1.00 20.00  ? 408 HEX A H32  1 
HETATM 4600 H H41  . HEX T 5 .   ? 144.554 133.664 115.850 1.00 20.00  ? 408 HEX A H41  1 
HETATM 4601 H H42  . HEX T 5 .   ? 143.913 132.038 115.596 1.00 20.00  ? 408 HEX A H42  1 
HETATM 4602 H H51  . HEX T 5 .   ? 146.456 132.363 117.120 1.00 20.00  ? 408 HEX A H51  1 
HETATM 4603 H H52  . HEX T 5 .   ? 144.930 132.750 117.925 1.00 20.00  ? 408 HEX A H52  1 
HETATM 4604 H H61  . HEX T 5 .   ? 145.467 130.447 118.388 1.00 20.00  ? 408 HEX A H61  1 
HETATM 4605 H H62  . HEX T 5 .   ? 145.717 130.116 116.668 1.00 20.00  ? 408 HEX A H62  1 
HETATM 4606 H H63  . HEX T 5 .   ? 144.095 130.483 117.269 1.00 20.00  ? 408 HEX A H63  1 
HETATM 4607 C C1   . EIC U 6 .   ? 111.565 105.562 110.500 1.00 20.00  ? 409 EIC A C1   1 
HETATM 4608 C C2   . EIC U 6 .   ? 111.300 106.056 111.917 1.00 20.00  ? 409 EIC A C2   1 
HETATM 4609 C C3   . EIC U 6 .   ? 112.553 106.615 112.613 1.00 20.00  ? 409 EIC A C3   1 
HETATM 4610 C C4   . EIC U 6 .   ? 112.188 107.689 113.639 1.00 20.00  ? 409 EIC A C4   1 
HETATM 4611 C C5   . EIC U 6 .   ? 113.432 108.096 114.434 1.00 20.00  ? 409 EIC A C5   1 
HETATM 4612 C C6   . EIC U 6 .   ? 113.399 109.590 114.760 1.00 20.00  ? 409 EIC A C6   1 
HETATM 4613 C C7   . EIC U 6 .   ? 114.207 109.904 116.022 1.00 20.00  ? 409 EIC A C7   1 
HETATM 4614 C C8   . EIC U 6 .   ? 113.414 109.579 117.289 1.00 20.00  ? 409 EIC A C8   1 
HETATM 4615 C C9   . EIC U 6 .   ? 114.176 110.074 118.491 1.00 20.00  ? 409 EIC A C9   1 
HETATM 4616 C C10  . EIC U 6 .   ? 113.671 110.471 119.656 1.00 20.00  ? 409 EIC A C10  1 
HETATM 4617 C C11  . EIC U 6 .   ? 112.219 110.523 120.066 1.00 20.00  ? 409 EIC A C11  1 
HETATM 4618 C C12  . EIC U 6 .   ? 112.151 111.025 121.490 1.00 20.00  ? 409 EIC A C12  1 
HETATM 4619 C C13  . EIC U 6 .   ? 111.474 110.519 122.525 1.00 20.00  ? 409 EIC A C13  1 
HETATM 4620 C C14  . EIC U 6 .   ? 110.576 109.303 122.540 1.00 20.00  ? 409 EIC A C14  1 
HETATM 4621 C C15  . EIC U 6 .   ? 110.546 108.675 123.940 1.00 20.00  ? 409 EIC A C15  1 
HETATM 4622 C C16  . EIC U 6 .   ? 109.327 107.762 124.127 1.00 20.00  ? 409 EIC A C16  1 
HETATM 4623 C C17  . EIC U 6 .   ? 109.422 106.511 123.245 1.00 20.00  ? 409 EIC A C17  1 
HETATM 4624 C C18  . EIC U 6 .   ? 109.278 105.228 124.069 1.00 20.00  ? 409 EIC A C18  1 
HETATM 4625 O O1   . EIC U 6 .   ? 112.635 105.060 110.245 1.00 20.00  ? 409 EIC A O1   1 
HETATM 4626 O O2   . EIC U 6 .   ? 110.678 105.711 109.695 1.00 20.00  ? 409 EIC A O2   1 
HETATM 4627 H H21  . EIC U 6 .   ? 110.893 105.222 112.501 1.00 20.00  ? 409 EIC A H21  1 
HETATM 4628 H H22  . EIC U 6 .   ? 110.530 106.836 111.868 1.00 20.00  ? 409 EIC A H22  1 
HETATM 4629 H H31  . EIC U 6 .   ? 113.231 107.041 111.862 1.00 20.00  ? 409 EIC A H31  1 
HETATM 4630 H H32  . EIC U 6 .   ? 113.091 105.796 113.109 1.00 20.00  ? 409 EIC A H32  1 
HETATM 4631 H H41  . EIC U 6 .   ? 111.415 107.301 114.314 1.00 20.00  ? 409 EIC A H41  1 
HETATM 4632 H H42  . EIC U 6 .   ? 111.769 108.563 113.124 1.00 20.00  ? 409 EIC A H42  1 
HETATM 4633 H H51  . EIC U 6 .   ? 113.488 107.501 115.354 1.00 20.00  ? 409 EIC A H51  1 
HETATM 4634 H H52  . EIC U 6 .   ? 114.329 107.869 113.846 1.00 20.00  ? 409 EIC A H52  1 
HETATM 4635 H H61  . EIC U 6 .   ? 112.357 109.908 114.902 1.00 20.00  ? 409 EIC A H61  1 
HETATM 4636 H H62  . EIC U 6 .   ? 113.805 110.159 113.912 1.00 20.00  ? 409 EIC A H62  1 
HETATM 4637 H H71  . EIC U 6 .   ? 115.125 109.309 116.003 1.00 20.00  ? 409 EIC A H71  1 
HETATM 4638 H H72  . EIC U 6 .   ? 114.491 110.964 116.032 1.00 20.00  ? 409 EIC A H72  1 
HETATM 4639 H H81  . EIC U 6 .   ? 113.269 108.495 117.364 1.00 20.00  ? 409 EIC A H81  1 
HETATM 4640 H H82  . EIC U 6 .   ? 112.419 110.026 117.213 1.00 20.00  ? 409 EIC A H82  1 
HETATM 4641 H H91  . EIC U 6 .   ? 115.255 110.097 118.349 1.00 20.00  ? 409 EIC A H91  1 
HETATM 4642 H H1O1 . EIC U 6 .   ? 114.354 110.806 120.437 1.00 20.00  ? 409 EIC A H1O1 1 
HETATM 4643 H H111 . EIC U 6 .   ? 111.747 109.538 120.004 1.00 20.00  ? 409 EIC A H111 1 
HETATM 4644 H H112 . EIC U 6 .   ? 111.685 111.180 119.371 1.00 20.00  ? 409 EIC A H112 1 
HETATM 4645 H H121 . EIC U 6 .   ? 112.757 111.915 121.654 1.00 20.00  ? 409 EIC A H121 1 
HETATM 4646 H H131 . EIC U 6 .   ? 111.549 111.023 123.487 1.00 20.00  ? 409 EIC A H131 1 
HETATM 4647 H H141 . EIC U 6 .   ? 110.901 108.548 121.817 1.00 20.00  ? 409 EIC A H141 1 
HETATM 4648 H H142 . EIC U 6 .   ? 109.558 109.596 122.252 1.00 20.00  ? 409 EIC A H142 1 
HETATM 4649 H H151 . EIC U 6 .   ? 110.536 109.469 124.696 1.00 20.00  ? 409 EIC A H151 1 
HETATM 4650 H H152 . EIC U 6 .   ? 111.459 108.085 124.090 1.00 20.00  ? 409 EIC A H152 1 
HETATM 4651 H H161 . EIC U 6 .   ? 108.415 108.319 123.871 1.00 20.00  ? 409 EIC A H161 1 
HETATM 4652 H H162 . EIC U 6 .   ? 109.245 107.463 125.182 1.00 20.00  ? 409 EIC A H162 1 
HETATM 4653 H H171 . EIC U 6 .   ? 110.388 106.499 122.727 1.00 20.00  ? 409 EIC A H171 1 
HETATM 4654 H H172 . EIC U 6 .   ? 108.640 106.536 122.478 1.00 20.00  ? 409 EIC A H172 1 
HETATM 4655 H H181 . EIC U 6 .   ? 108.364 105.267 124.673 1.00 20.00  ? 409 EIC A H181 1 
HETATM 4656 H H182 . EIC U 6 .   ? 109.229 104.346 123.418 1.00 20.00  ? 409 EIC A H182 1 
HETATM 4657 H H183 . EIC U 6 .   ? 110.131 105.108 124.751 1.00 20.00  ? 409 EIC A H183 1 
HETATM 4658 K K    . K   V 7 .   ? 120.225 120.247 109.187 1.00 44.37  ? 410 K   A K    1 
HETATM 4659 K K    . K   W 7 .   ? 120.237 120.254 115.028 1.00 33.61  ? 411 K   A K    1 
HETATM 4660 K K    . K   X 7 .   ? 120.230 120.252 112.211 1.00 60.30  ? 412 K   A K    1 
# 
