data_9BVZ
# 
_entry.id   9BVZ 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BVZ         pdb_00009bvz 10.2210/pdb9bvz/pdb 
WWPDB D_1000284235 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-05-21 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BVZ 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-20 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              laurenblankenship02@tamu.edu 
_pdbx_contact_author.name_first         Lauren 
_pdbx_contact_author.name_last          Blankenship 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-1714-4399 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Liu, W.R.'         1 0000-0002-7078-6534 
'Blankenship, L.R.' 2 0000-0002-1714-4399 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'SARS-CoV-2 main protease' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Liu, W.R.'         1 0000-0002-7078-6534 
primary 'Blankenship, L.R.' 2 0000-0002-1714-4399 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '3C-like proteinase nsp5'                   33825.547 1   3.4.22.69 ? ? ? 
2 non-polymer syn '[2-(iminomethyl)pyridin-3-yl]boronic acid' 149.943   1   ?         ? ? ? 
3 water       nat water                                       18.015    162 ?         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 '[2-(iminomethyl)pyridin-3-yl]boronic acid' A1AS4 
3 water                                       HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   GLY n 
1 3   PHE n 
1 4   ARG n 
1 5   LYS n 
1 6   MET n 
1 7   ALA n 
1 8   PHE n 
1 9   PRO n 
1 10  SER n 
1 11  GLY n 
1 12  LYS n 
1 13  VAL n 
1 14  GLU n 
1 15  GLY n 
1 16  CYS n 
1 17  MET n 
1 18  VAL n 
1 19  GLN n 
1 20  VAL n 
1 21  THR n 
1 22  CYS n 
1 23  GLY n 
1 24  THR n 
1 25  THR n 
1 26  THR n 
1 27  LEU n 
1 28  ASN n 
1 29  GLY n 
1 30  LEU n 
1 31  TRP n 
1 32  LEU n 
1 33  ASP n 
1 34  ASP n 
1 35  VAL n 
1 36  VAL n 
1 37  TYR n 
1 38  CYS n 
1 39  PRO n 
1 40  ARG n 
1 41  HIS n 
1 42  VAL n 
1 43  ILE n 
1 44  CYS n 
1 45  THR n 
1 46  SER n 
1 47  GLU n 
1 48  ASP n 
1 49  MET n 
1 50  LEU n 
1 51  ASN n 
1 52  PRO n 
1 53  ASN n 
1 54  TYR n 
1 55  GLU n 
1 56  ASP n 
1 57  LEU n 
1 58  LEU n 
1 59  ILE n 
1 60  ARG n 
1 61  LYS n 
1 62  SER n 
1 63  ASN n 
1 64  HIS n 
1 65  ASN n 
1 66  PHE n 
1 67  LEU n 
1 68  VAL n 
1 69  GLN n 
1 70  ALA n 
1 71  GLY n 
1 72  ASN n 
1 73  VAL n 
1 74  GLN n 
1 75  LEU n 
1 76  ARG n 
1 77  VAL n 
1 78  ILE n 
1 79  GLY n 
1 80  HIS n 
1 81  SER n 
1 82  MET n 
1 83  GLN n 
1 84  ASN n 
1 85  CYS n 
1 86  VAL n 
1 87  LEU n 
1 88  LYS n 
1 89  LEU n 
1 90  LYS n 
1 91  VAL n 
1 92  ASP n 
1 93  THR n 
1 94  ALA n 
1 95  ASN n 
1 96  PRO n 
1 97  LYS n 
1 98  THR n 
1 99  PRO n 
1 100 LYS n 
1 101 TYR n 
1 102 LYS n 
1 103 PHE n 
1 104 VAL n 
1 105 ARG n 
1 106 ILE n 
1 107 GLN n 
1 108 PRO n 
1 109 GLY n 
1 110 GLN n 
1 111 THR n 
1 112 PHE n 
1 113 SER n 
1 114 VAL n 
1 115 LEU n 
1 116 ALA n 
1 117 CYS n 
1 118 TYR n 
1 119 ASN n 
1 120 GLY n 
1 121 SER n 
1 122 PRO n 
1 123 SER n 
1 124 GLY n 
1 125 VAL n 
1 126 TYR n 
1 127 GLN n 
1 128 CYS n 
1 129 ALA n 
1 130 MET n 
1 131 ARG n 
1 132 PRO n 
1 133 ASN n 
1 134 PHE n 
1 135 THR n 
1 136 ILE n 
1 137 LYS n 
1 138 GLY n 
1 139 SER n 
1 140 PHE n 
1 141 LEU n 
1 142 ASN n 
1 143 GLY n 
1 144 SER n 
1 145 CYS n 
1 146 GLY n 
1 147 SER n 
1 148 VAL n 
1 149 GLY n 
1 150 PHE n 
1 151 ASN n 
1 152 ILE n 
1 153 ASP n 
1 154 TYR n 
1 155 ASP n 
1 156 CYS n 
1 157 VAL n 
1 158 SER n 
1 159 PHE n 
1 160 CYS n 
1 161 TYR n 
1 162 MET n 
1 163 HIS n 
1 164 HIS n 
1 165 MET n 
1 166 GLU n 
1 167 LEU n 
1 168 PRO n 
1 169 THR n 
1 170 GLY n 
1 171 VAL n 
1 172 HIS n 
1 173 ALA n 
1 174 GLY n 
1 175 THR n 
1 176 ASP n 
1 177 LEU n 
1 178 GLU n 
1 179 GLY n 
1 180 ASN n 
1 181 PHE n 
1 182 TYR n 
1 183 GLY n 
1 184 PRO n 
1 185 PHE n 
1 186 VAL n 
1 187 ASP n 
1 188 ARG n 
1 189 GLN n 
1 190 THR n 
1 191 ALA n 
1 192 GLN n 
1 193 ALA n 
1 194 ALA n 
1 195 GLY n 
1 196 THR n 
1 197 ASP n 
1 198 THR n 
1 199 THR n 
1 200 ILE n 
1 201 THR n 
1 202 VAL n 
1 203 ASN n 
1 204 VAL n 
1 205 LEU n 
1 206 ALA n 
1 207 TRP n 
1 208 LEU n 
1 209 TYR n 
1 210 ALA n 
1 211 ALA n 
1 212 VAL n 
1 213 ILE n 
1 214 ASN n 
1 215 GLY n 
1 216 ASP n 
1 217 ARG n 
1 218 TRP n 
1 219 PHE n 
1 220 LEU n 
1 221 ASN n 
1 222 ARG n 
1 223 PHE n 
1 224 THR n 
1 225 THR n 
1 226 THR n 
1 227 LEU n 
1 228 ASN n 
1 229 ASP n 
1 230 PHE n 
1 231 ASN n 
1 232 LEU n 
1 233 VAL n 
1 234 ALA n 
1 235 MET n 
1 236 LYS n 
1 237 TYR n 
1 238 ASN n 
1 239 TYR n 
1 240 GLU n 
1 241 PRO n 
1 242 LEU n 
1 243 THR n 
1 244 GLN n 
1 245 ASP n 
1 246 HIS n 
1 247 VAL n 
1 248 ASP n 
1 249 ILE n 
1 250 LEU n 
1 251 GLY n 
1 252 PRO n 
1 253 LEU n 
1 254 SER n 
1 255 ALA n 
1 256 GLN n 
1 257 THR n 
1 258 GLY n 
1 259 ILE n 
1 260 ALA n 
1 261 VAL n 
1 262 LEU n 
1 263 ASP n 
1 264 MET n 
1 265 CYS n 
1 266 ALA n 
1 267 SER n 
1 268 LEU n 
1 269 LYS n 
1 270 GLU n 
1 271 LEU n 
1 272 LEU n 
1 273 GLN n 
1 274 ASN n 
1 275 GLY n 
1 276 MET n 
1 277 ASN n 
1 278 GLY n 
1 279 ARG n 
1 280 THR n 
1 281 ILE n 
1 282 LEU n 
1 283 GLY n 
1 284 SER n 
1 285 ALA n 
1 286 LEU n 
1 287 LEU n 
1 288 GLU n 
1 289 ASP n 
1 290 GLU n 
1 291 PHE n 
1 292 THR n 
1 293 PRO n 
1 294 PHE n 
1 295 ASP n 
1 296 VAL n 
1 297 VAL n 
1 298 ARG n 
1 299 GLN n 
1 300 CYS n 
1 301 SER n 
1 302 GLY n 
1 303 VAL n 
1 304 THR n 
1 305 PHE n 
1 306 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   306 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'rep, 1a-1b' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1AS4 non-polymer         . '[2-(iminomethyl)pyridin-3-yl]boronic acid' ? 'C6 H7 B N2 O2'  149.943 
ALA   'L-peptide linking' y ALANINE                                     ? 'C3 H7 N O2'     89.093  
ARG   'L-peptide linking' y ARGININE                                    ? 'C6 H15 N4 O2 1' 175.209 
ASN   'L-peptide linking' y ASPARAGINE                                  ? 'C4 H8 N2 O3'    132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID'                             ? 'C4 H7 N O4'     133.103 
CYS   'L-peptide linking' y CYSTEINE                                    ? 'C3 H7 N O2 S'   121.158 
GLN   'L-peptide linking' y GLUTAMINE                                   ? 'C5 H10 N2 O3'   146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID'                             ? 'C5 H9 N O4'     147.129 
GLY   'peptide linking'   y GLYCINE                                     ? 'C2 H5 N O2'     75.067  
HIS   'L-peptide linking' y HISTIDINE                                   ? 'C6 H10 N3 O2 1' 156.162 
HOH   non-polymer         . WATER                                       ? 'H2 O'           18.015  
ILE   'L-peptide linking' y ISOLEUCINE                                  ? 'C6 H13 N O2'    131.173 
LEU   'L-peptide linking' y LEUCINE                                     ? 'C6 H13 N O2'    131.173 
LYS   'L-peptide linking' y LYSINE                                      ? 'C6 H15 N2 O2 1' 147.195 
MET   'L-peptide linking' y METHIONINE                                  ? 'C5 H11 N O2 S'  149.211 
PHE   'L-peptide linking' y PHENYLALANINE                               ? 'C9 H11 N O2'    165.189 
PRO   'L-peptide linking' y PROLINE                                     ? 'C5 H9 N O2'     115.130 
SER   'L-peptide linking' y SERINE                                      ? 'C3 H7 N O3'     105.093 
THR   'L-peptide linking' y THREONINE                                   ? 'C4 H9 N O3'     119.119 
TRP   'L-peptide linking' y TRYPTOPHAN                                  ? 'C11 H12 N2 O2'  204.225 
TYR   'L-peptide linking' y TYROSINE                                    ? 'C9 H11 N O3'    181.189 
VAL   'L-peptide linking' y VALINE                                      ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   1   1   SER SER A . n 
A 1 2   GLY 2   2   2   GLY GLY A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   ARG 4   4   4   ARG ARG A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   MET 6   6   6   MET MET A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   PRO 9   9   9   PRO PRO A . n 
A 1 10  SER 10  10  10  SER SER A . n 
A 1 11  GLY 11  11  11  GLY GLY A . n 
A 1 12  LYS 12  12  12  LYS LYS A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  GLY 15  15  15  GLY GLY A . n 
A 1 16  CYS 16  16  16  CYS CYS A . n 
A 1 17  MET 17  17  17  MET MET A . n 
A 1 18  VAL 18  18  18  VAL VAL A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  THR 21  21  21  THR THR A . n 
A 1 22  CYS 22  22  22  CYS CYS A . n 
A 1 23  GLY 23  23  23  GLY GLY A . n 
A 1 24  THR 24  24  24  THR THR A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  THR 26  26  26  THR THR A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  ASN 28  28  28  ASN ASN A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  TRP 31  31  31  TRP TRP A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  ASP 33  33  33  ASP ASP A . n 
A 1 34  ASP 34  34  34  ASP ASP A . n 
A 1 35  VAL 35  35  35  VAL VAL A . n 
A 1 36  VAL 36  36  36  VAL VAL A . n 
A 1 37  TYR 37  37  37  TYR TYR A . n 
A 1 38  CYS 38  38  38  CYS CYS A . n 
A 1 39  PRO 39  39  39  PRO PRO A . n 
A 1 40  ARG 40  40  40  ARG ARG A . n 
A 1 41  HIS 41  41  41  HIS HIS A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  ILE 43  43  43  ILE ILE A . n 
A 1 44  CYS 44  44  44  CYS CYS A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  SER 46  46  46  SER SER A . n 
A 1 47  GLU 47  47  47  GLU GLU A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  MET 49  49  49  MET MET A . n 
A 1 50  LEU 50  50  50  LEU LEU A . n 
A 1 51  ASN 51  51  51  ASN ASN A . n 
A 1 52  PRO 52  52  52  PRO PRO A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  TYR 54  54  54  TYR TYR A . n 
A 1 55  GLU 55  55  55  GLU GLU A . n 
A 1 56  ASP 56  56  56  ASP ASP A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  ILE 59  59  59  ILE ILE A . n 
A 1 60  ARG 60  60  60  ARG ARG A . n 
A 1 61  LYS 61  61  61  LYS LYS A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  ASN 63  63  63  ASN ASN A . n 
A 1 64  HIS 64  64  64  HIS HIS A . n 
A 1 65  ASN 65  65  65  ASN ASN A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  GLN 69  69  69  GLN GLN A . n 
A 1 70  ALA 70  70  70  ALA ALA A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  ASN 72  72  72  ASN ASN A . n 
A 1 73  VAL 73  73  73  VAL VAL A . n 
A 1 74  GLN 74  74  74  GLN GLN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  ARG 76  76  76  ARG ARG A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  GLY 79  79  79  GLY GLY A . n 
A 1 80  HIS 80  80  80  HIS HIS A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  MET 82  82  82  MET MET A . n 
A 1 83  GLN 83  83  83  GLN GLN A . n 
A 1 84  ASN 84  84  84  ASN ASN A . n 
A 1 85  CYS 85  85  85  CYS CYS A . n 
A 1 86  VAL 86  86  86  VAL VAL A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  LYS 88  88  88  LYS LYS A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  LYS 90  90  90  LYS LYS A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  ASP 92  92  92  ASP ASP A . n 
A 1 93  THR 93  93  93  THR THR A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  PRO 96  96  96  PRO PRO A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  PRO 99  99  99  PRO PRO A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 TYR 101 101 101 TYR TYR A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 PHE 103 103 103 PHE PHE A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 ARG 105 105 105 ARG ARG A . n 
A 1 106 ILE 106 106 106 ILE ILE A . n 
A 1 107 GLN 107 107 107 GLN GLN A . n 
A 1 108 PRO 108 108 108 PRO PRO A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 GLN 110 110 110 GLN GLN A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 PHE 112 112 112 PHE PHE A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 CYS 117 117 117 CYS CYS A . n 
A 1 118 TYR 118 118 118 TYR TYR A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 SER 123 123 123 SER SER A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 MET 130 130 130 MET MET A . n 
A 1 131 ARG 131 131 131 ARG ARG A . n 
A 1 132 PRO 132 132 132 PRO PRO A . n 
A 1 133 ASN 133 133 133 ASN ASN A . n 
A 1 134 PHE 134 134 134 PHE PHE A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 LYS 137 137 137 LYS LYS A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 PHE 140 140 140 PHE PHE A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 ASN 142 142 142 ASN ASN A . n 
A 1 143 GLY 143 143 143 GLY GLY A . n 
A 1 144 SER 144 144 144 SER SER A . n 
A 1 145 CYS 145 145 145 CYS CYS A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 GLY 149 149 149 GLY GLY A . n 
A 1 150 PHE 150 150 150 PHE PHE A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 ILE 152 152 152 ILE ILE A . n 
A 1 153 ASP 153 153 153 ASP ASP A . n 
A 1 154 TYR 154 154 154 TYR TYR A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 CYS 156 156 156 CYS CYS A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 SER 158 158 158 SER SER A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 CYS 160 160 160 CYS CYS A . n 
A 1 161 TYR 161 161 161 TYR TYR A . n 
A 1 162 MET 162 162 162 MET MET A . n 
A 1 163 HIS 163 163 163 HIS HIS A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 MET 165 165 165 MET MET A . n 
A 1 166 GLU 166 166 166 GLU GLU A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 PRO 168 168 168 PRO PRO A . n 
A 1 169 THR 169 169 169 THR THR A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 VAL 171 171 171 VAL VAL A . n 
A 1 172 HIS 172 172 172 HIS HIS A . n 
A 1 173 ALA 173 173 173 ALA ALA A . n 
A 1 174 GLY 174 174 174 GLY GLY A . n 
A 1 175 THR 175 175 175 THR THR A . n 
A 1 176 ASP 176 176 176 ASP ASP A . n 
A 1 177 LEU 177 177 177 LEU LEU A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 TYR 182 182 182 TYR TYR A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 VAL 186 186 186 VAL VAL A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 GLN 189 189 189 GLN GLN A . n 
A 1 190 THR 190 190 190 THR THR A . n 
A 1 191 ALA 191 191 191 ALA ALA A . n 
A 1 192 GLN 192 192 192 GLN GLN A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 THR 196 196 196 THR THR A . n 
A 1 197 ASP 197 197 197 ASP ASP A . n 
A 1 198 THR 198 198 198 THR THR A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 ILE 200 200 200 ILE ILE A . n 
A 1 201 THR 201 201 201 THR THR A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 ALA 206 206 206 ALA ALA A . n 
A 1 207 TRP 207 207 207 TRP TRP A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ALA 210 210 210 ALA ALA A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ASN 214 214 214 ASN ASN A . n 
A 1 215 GLY 215 215 215 GLY GLY A . n 
A 1 216 ASP 216 216 216 ASP ASP A . n 
A 1 217 ARG 217 217 217 ARG ARG A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 ASN 221 221 221 ASN ASN A . n 
A 1 222 ARG 222 222 222 ARG ARG A . n 
A 1 223 PHE 223 223 223 PHE PHE A . n 
A 1 224 THR 224 224 224 THR THR A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 THR 226 226 226 THR THR A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 ASN 228 228 228 ASN ASN A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 PHE 230 230 230 PHE PHE A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 VAL 233 233 233 VAL VAL A . n 
A 1 234 ALA 234 234 234 ALA ALA A . n 
A 1 235 MET 235 235 235 MET MET A . n 
A 1 236 LYS 236 236 236 LYS LYS A . n 
A 1 237 TYR 237 237 237 TYR TYR A . n 
A 1 238 ASN 238 238 238 ASN ASN A . n 
A 1 239 TYR 239 239 239 TYR TYR A . n 
A 1 240 GLU 240 240 240 GLU GLU A . n 
A 1 241 PRO 241 241 241 PRO PRO A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 THR 243 243 243 THR THR A . n 
A 1 244 GLN 244 244 244 GLN GLN A . n 
A 1 245 ASP 245 245 245 ASP ASP A . n 
A 1 246 HIS 246 246 246 HIS HIS A . n 
A 1 247 VAL 247 247 247 VAL VAL A . n 
A 1 248 ASP 248 248 248 ASP ASP A . n 
A 1 249 ILE 249 249 249 ILE ILE A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 PRO 252 252 252 PRO PRO A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 SER 254 254 254 SER SER A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 THR 257 257 257 THR THR A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 ILE 259 259 259 ILE ILE A . n 
A 1 260 ALA 260 260 260 ALA ALA A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 LEU 262 262 262 LEU LEU A . n 
A 1 263 ASP 263 263 263 ASP ASP A . n 
A 1 264 MET 264 264 264 MET MET A . n 
A 1 265 CYS 265 265 265 CYS CYS A . n 
A 1 266 ALA 266 266 266 ALA ALA A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 LYS 269 269 269 LYS LYS A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 LEU 271 271 271 LEU LEU A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 ASN 274 274 274 ASN ASN A . n 
A 1 275 GLY 275 275 275 GLY GLY A . n 
A 1 276 MET 276 276 276 MET MET A . n 
A 1 277 ASN 277 277 277 ASN ASN A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 ARG 279 279 279 ARG ARG A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 ILE 281 281 281 ILE ILE A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 GLY 283 283 283 GLY GLY A . n 
A 1 284 SER 284 284 284 SER SER A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 LEU 286 286 286 LEU LEU A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 ASP 289 289 289 ASP ASP A . n 
A 1 290 GLU 290 290 290 GLU GLU A . n 
A 1 291 PHE 291 291 291 PHE PHE A . n 
A 1 292 THR 292 292 292 THR THR A . n 
A 1 293 PRO 293 293 293 PRO PRO A . n 
A 1 294 PHE 294 294 294 PHE PHE A . n 
A 1 295 ASP 295 295 295 ASP ASP A . n 
A 1 296 VAL 296 296 296 VAL VAL A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 GLN 299 299 299 GLN GLN A . n 
A 1 300 CYS 300 300 300 CYS CYS A . n 
A 1 301 SER 301 301 301 SER SER A . n 
A 1 302 GLY 302 302 302 GLY GLY A . n 
A 1 303 VAL 303 303 303 VAL VAL A . n 
A 1 304 THR 304 304 304 THR THR A . n 
A 1 305 PHE 305 305 305 PHE PHE A . n 
A 1 306 GLN 306 306 306 GLN GLN A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1AS4 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1AS4 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 A1AS4 1   401 401 A1AS4 LIG A . 
C 3 HOH   1   501 11  HOH   HOH A . 
C 3 HOH   2   502 115 HOH   HOH A . 
C 3 HOH   3   503 160 HOH   HOH A . 
C 3 HOH   4   504 121 HOH   HOH A . 
C 3 HOH   5   505 72  HOH   HOH A . 
C 3 HOH   6   506 57  HOH   HOH A . 
C 3 HOH   7   507 81  HOH   HOH A . 
C 3 HOH   8   508 61  HOH   HOH A . 
C 3 HOH   9   509 117 HOH   HOH A . 
C 3 HOH   10  510 94  HOH   HOH A . 
C 3 HOH   11  511 68  HOH   HOH A . 
C 3 HOH   12  512 54  HOH   HOH A . 
C 3 HOH   13  513 124 HOH   HOH A . 
C 3 HOH   14  514 98  HOH   HOH A . 
C 3 HOH   15  515 86  HOH   HOH A . 
C 3 HOH   16  516 59  HOH   HOH A . 
C 3 HOH   17  517 133 HOH   HOH A . 
C 3 HOH   18  518 155 HOH   HOH A . 
C 3 HOH   19  519 93  HOH   HOH A . 
C 3 HOH   20  520 41  HOH   HOH A . 
C 3 HOH   21  521 143 HOH   HOH A . 
C 3 HOH   22  522 36  HOH   HOH A . 
C 3 HOH   23  523 34  HOH   HOH A . 
C 3 HOH   24  524 38  HOH   HOH A . 
C 3 HOH   25  525 97  HOH   HOH A . 
C 3 HOH   26  526 56  HOH   HOH A . 
C 3 HOH   27  527 84  HOH   HOH A . 
C 3 HOH   28  528 140 HOH   HOH A . 
C 3 HOH   29  529 142 HOH   HOH A . 
C 3 HOH   30  530 23  HOH   HOH A . 
C 3 HOH   31  531 120 HOH   HOH A . 
C 3 HOH   32  532 134 HOH   HOH A . 
C 3 HOH   33  533 8   HOH   HOH A . 
C 3 HOH   34  534 116 HOH   HOH A . 
C 3 HOH   35  535 62  HOH   HOH A . 
C 3 HOH   36  536 69  HOH   HOH A . 
C 3 HOH   37  537 12  HOH   HOH A . 
C 3 HOH   38  538 145 HOH   HOH A . 
C 3 HOH   39  539 89  HOH   HOH A . 
C 3 HOH   40  540 53  HOH   HOH A . 
C 3 HOH   41  541 35  HOH   HOH A . 
C 3 HOH   42  542 67  HOH   HOH A . 
C 3 HOH   43  543 10  HOH   HOH A . 
C 3 HOH   44  544 32  HOH   HOH A . 
C 3 HOH   45  545 102 HOH   HOH A . 
C 3 HOH   46  546 31  HOH   HOH A . 
C 3 HOH   47  547 82  HOH   HOH A . 
C 3 HOH   48  548 85  HOH   HOH A . 
C 3 HOH   49  549 18  HOH   HOH A . 
C 3 HOH   50  550 47  HOH   HOH A . 
C 3 HOH   51  551 144 HOH   HOH A . 
C 3 HOH   52  552 27  HOH   HOH A . 
C 3 HOH   53  553 24  HOH   HOH A . 
C 3 HOH   54  554 80  HOH   HOH A . 
C 3 HOH   55  555 108 HOH   HOH A . 
C 3 HOH   56  556 1   HOH   HOH A . 
C 3 HOH   57  557 114 HOH   HOH A . 
C 3 HOH   58  558 46  HOH   HOH A . 
C 3 HOH   59  559 20  HOH   HOH A . 
C 3 HOH   60  560 151 HOH   HOH A . 
C 3 HOH   61  561 125 HOH   HOH A . 
C 3 HOH   62  562 99  HOH   HOH A . 
C 3 HOH   63  563 109 HOH   HOH A . 
C 3 HOH   64  564 88  HOH   HOH A . 
C 3 HOH   65  565 83  HOH   HOH A . 
C 3 HOH   66  566 13  HOH   HOH A . 
C 3 HOH   67  567 28  HOH   HOH A . 
C 3 HOH   68  568 17  HOH   HOH A . 
C 3 HOH   69  569 6   HOH   HOH A . 
C 3 HOH   70  570 158 HOH   HOH A . 
C 3 HOH   71  571 25  HOH   HOH A . 
C 3 HOH   72  572 26  HOH   HOH A . 
C 3 HOH   73  573 126 HOH   HOH A . 
C 3 HOH   74  574 104 HOH   HOH A . 
C 3 HOH   75  575 21  HOH   HOH A . 
C 3 HOH   76  576 148 HOH   HOH A . 
C 3 HOH   77  577 4   HOH   HOH A . 
C 3 HOH   78  578 65  HOH   HOH A . 
C 3 HOH   79  579 74  HOH   HOH A . 
C 3 HOH   80  580 95  HOH   HOH A . 
C 3 HOH   81  581 3   HOH   HOH A . 
C 3 HOH   82  582 87  HOH   HOH A . 
C 3 HOH   83  583 156 HOH   HOH A . 
C 3 HOH   84  584 162 HOH   HOH A . 
C 3 HOH   85  585 147 HOH   HOH A . 
C 3 HOH   86  586 100 HOH   HOH A . 
C 3 HOH   87  587 66  HOH   HOH A . 
C 3 HOH   88  588 70  HOH   HOH A . 
C 3 HOH   89  589 40  HOH   HOH A . 
C 3 HOH   90  590 19  HOH   HOH A . 
C 3 HOH   91  591 42  HOH   HOH A . 
C 3 HOH   92  592 103 HOH   HOH A . 
C 3 HOH   93  593 132 HOH   HOH A . 
C 3 HOH   94  594 43  HOH   HOH A . 
C 3 HOH   95  595 92  HOH   HOH A . 
C 3 HOH   96  596 7   HOH   HOH A . 
C 3 HOH   97  597 45  HOH   HOH A . 
C 3 HOH   98  598 51  HOH   HOH A . 
C 3 HOH   99  599 105 HOH   HOH A . 
C 3 HOH   100 600 149 HOH   HOH A . 
C 3 HOH   101 601 49  HOH   HOH A . 
C 3 HOH   102 602 9   HOH   HOH A . 
C 3 HOH   103 603 14  HOH   HOH A . 
C 3 HOH   104 604 128 HOH   HOH A . 
C 3 HOH   105 605 137 HOH   HOH A . 
C 3 HOH   106 606 58  HOH   HOH A . 
C 3 HOH   107 607 73  HOH   HOH A . 
C 3 HOH   108 608 16  HOH   HOH A . 
C 3 HOH   109 609 123 HOH   HOH A . 
C 3 HOH   110 610 141 HOH   HOH A . 
C 3 HOH   111 611 2   HOH   HOH A . 
C 3 HOH   112 612 90  HOH   HOH A . 
C 3 HOH   113 613 52  HOH   HOH A . 
C 3 HOH   114 614 159 HOH   HOH A . 
C 3 HOH   115 615 22  HOH   HOH A . 
C 3 HOH   116 616 33  HOH   HOH A . 
C 3 HOH   117 617 146 HOH   HOH A . 
C 3 HOH   118 618 153 HOH   HOH A . 
C 3 HOH   119 619 152 HOH   HOH A . 
C 3 HOH   120 620 136 HOH   HOH A . 
C 3 HOH   121 621 150 HOH   HOH A . 
C 3 HOH   122 622 71  HOH   HOH A . 
C 3 HOH   123 623 48  HOH   HOH A . 
C 3 HOH   124 624 15  HOH   HOH A . 
C 3 HOH   125 625 39  HOH   HOH A . 
C 3 HOH   126 626 77  HOH   HOH A . 
C 3 HOH   127 627 78  HOH   HOH A . 
C 3 HOH   128 628 5   HOH   HOH A . 
C 3 HOH   129 629 50  HOH   HOH A . 
C 3 HOH   130 630 96  HOH   HOH A . 
C 3 HOH   131 631 29  HOH   HOH A . 
C 3 HOH   132 632 79  HOH   HOH A . 
C 3 HOH   133 633 135 HOH   HOH A . 
C 3 HOH   134 634 129 HOH   HOH A . 
C 3 HOH   135 635 127 HOH   HOH A . 
C 3 HOH   136 636 37  HOH   HOH A . 
C 3 HOH   137 637 44  HOH   HOH A . 
C 3 HOH   138 638 118 HOH   HOH A . 
C 3 HOH   139 639 91  HOH   HOH A . 
C 3 HOH   140 640 130 HOH   HOH A . 
C 3 HOH   141 641 111 HOH   HOH A . 
C 3 HOH   142 642 55  HOH   HOH A . 
C 3 HOH   143 643 110 HOH   HOH A . 
C 3 HOH   144 644 60  HOH   HOH A . 
C 3 HOH   145 645 64  HOH   HOH A . 
C 3 HOH   146 646 76  HOH   HOH A . 
C 3 HOH   147 647 106 HOH   HOH A . 
C 3 HOH   148 648 113 HOH   HOH A . 
C 3 HOH   149 649 122 HOH   HOH A . 
C 3 HOH   150 650 131 HOH   HOH A . 
C 3 HOH   151 651 63  HOH   HOH A . 
C 3 HOH   152 652 112 HOH   HOH A . 
C 3 HOH   153 653 119 HOH   HOH A . 
C 3 HOH   154 654 30  HOH   HOH A . 
C 3 HOH   155 655 157 HOH   HOH A . 
C 3 HOH   156 656 107 HOH   HOH A . 
C 3 HOH   157 657 154 HOH   HOH A . 
C 3 HOH   158 658 139 HOH   HOH A . 
C 3 HOH   159 659 75  HOH   HOH A . 
C 3 HOH   160 660 101 HOH   HOH A . 
C 3 HOH   161 661 138 HOH   HOH A . 
C 3 HOH   162 662 161 HOH   HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement        ? ? ? ? ? ? ? ? ? ? ? PHENIX         ? ? ? 1.18.2_3874 1 
? 'data extraction' ? ? ? ? ? ? ? ? ? ? ? PDB_EXTRACT    ? ? ? .           2 
? 'data reduction'  ? ? ? ? ? ? ? ? ? ? ? 'PROTEUM PLUS' ? ? ? .           3 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? Aimless        ? ? ? .           4 
? phasing           ? ? ? ? ? ? ? ? ? ? ? PHENIX         ? ? ? .           5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   96.279 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BVZ 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     51.962 
_cell.length_a_esd                 ? 
_cell.length_b                     81.678 
_cell.length_b_esd                 ? 
_cell.length_c                     91.322 
_cell.length_c_esd                 ? 
_cell.volume                       385258.862 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BVZ 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y (x,y,-x+z)' 
_symmetry.space_group_name_H-M             'I 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BVZ 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.77 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          55.54 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;0.2 M Ammonium phosphate dibasic, 17%
W/v PEG3350, pH8.0
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            289 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     120 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'Bruker PHOTON II' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-05-02 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.54301 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'ROTATING ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        'RIGAKU MICROMAX-002' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.54301 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          13.54 
_reflns.entry_id                                       9BVZ 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.0 
_reflns.d_resolution_low                               24.94 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     25502 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.30 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                2.0 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          6.27 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.1566 
_reflns.pdbx_Rpim_I_all                                0.1108 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.968 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.1108 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.0 
_reflns_shell.d_res_low                                     2.071 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.51 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2555 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               0.4331 
_reflns_shell.pdbx_Rpim_I_all                               0.3063 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.658 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.3063 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               19.92 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9BVZ 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.00 
_refine.ls_d_res_low                             24.94 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     25497 
_refine.ls_number_reflns_R_free                  1288 
_refine.ls_number_reflns_R_work                  24209 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.36 
_refine.ls_percent_reflns_R_free                 5.05 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2703 
_refine.ls_R_factor_R_free                       0.3209 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2676 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 34.8220 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.3841 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.00 
_refine_hist.d_res_low                        24.94 
_refine_hist.number_atoms_solvent             162 
_refine_hist.number_atoms_total               2540 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2367 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         11 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0093 ? 2431 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.1274 ? 3303 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0559 ? 371  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0071 ? 429  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 6.7561 ? 329  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.00 2.08  . . 171 2665 99.65 . . . . 0.3674 . . . . . . . . . . . 0.4281 
'X-RAY DIFFRACTION' 2.08 2.17  . . 141 2685 99.93 . . . . 0.3257 . . . . . . . . . . . 0.3917 
'X-RAY DIFFRACTION' 2.17 2.29  . . 136 2695 99.93 . . . . 0.3042 . . . . . . . . . . . 0.3742 
'X-RAY DIFFRACTION' 2.29 2.43  . . 127 2703 99.93 . . . . 0.2924 . . . . . . . . . . . 0.3154 
'X-RAY DIFFRACTION' 2.43 2.62  . . 138 2694 99.16 . . . . 0.2945 . . . . . . . . . . . 0.3227 
'X-RAY DIFFRACTION' 2.62 2.88  . . 141 2695 99.75 . . . . 0.2808 . . . . . . . . . . . 0.3513 
'X-RAY DIFFRACTION' 2.88 3.30  . . 140 2685 99.51 . . . . 0.2615 . . . . . . . . . . . 0.3055 
'X-RAY DIFFRACTION' 3.30 4.15  . . 154 2693 99.13 . . . . 0.2366 . . . . . . . . . . . 0.2992 
'X-RAY DIFFRACTION' 4.16 24.94 . . 140 2694 97.32 . . . . 0.2005 . . . . . . . . . . . 0.2426 
# 
_struct.entry_id                     9BVZ 
_struct.title                        'SARS-CoV-2 main protease bound to inhibitor AR-A-135' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BVZ 
_struct_keywords.text            'Covid-19, VIRAL PROTEIN, Hydrolase' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN, Hydrolase' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1AB_SARS2 
_struct_ref.pdbx_db_accession          P0DTD1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_struct_ref.pdbx_align_begin           3264 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9BVZ 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 306 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P0DTD1 
_struct_ref_seq.db_align_beg                  3264 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3569 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       306 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 4040  ? 
1 MORE         -5    ? 
1 'SSA (A^2)'  25290 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z     1.0000000000  0.0000000000 0.0000000000 0.0000000000   0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000 
2 'crystal symmetry operation' 2_455 -x-1,y,-z -1.0000000000 0.0000000000 0.0000000000 -51.9620000000 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 SER A 10  ? GLY A 15  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2 AA2 HIS A 41  ? CYS A 44  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3 AA3 ASN A 53  ? ARG A 60  ? ASN A 53  ARG A 60  1 ? 8  
HELX_P HELX_P4 AA4 ILE A 200 ? GLY A 215 ? ILE A 200 GLY A 215 1 ? 16 
HELX_P HELX_P5 AA5 THR A 226 ? TYR A 237 ? THR A 226 TYR A 237 1 ? 12 
HELX_P HELX_P6 AA6 THR A 243 ? GLY A 258 ? THR A 243 GLY A 258 1 ? 16 
HELX_P HELX_P7 AA7 ALA A 260 ? GLY A 275 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P8 AA8 THR A 292 ? CYS A 300 ? THR A 292 CYS A 300 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            covale1 
_struct_conn.conn_type_id                  covale 
_struct_conn.pdbx_leaving_atom_flag        none 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            145 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           B 
_struct_conn.ptnr2_label_comp_id           A1AS4 
_struct_conn.ptnr2_label_seq_id            . 
_struct_conn.ptnr2_label_atom_id           C6 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             145 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            A1AS4 
_struct_conn.ptnr2_auth_seq_id             401 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               1.826 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      A1AS4 
_pdbx_modification_feature.label_asym_id                      B 
_pdbx_modification_feature.label_seq_id                       . 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      145 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       A1AS4 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        401 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       145 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               C6 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                CYS 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        A1AS4 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Covalent chemical modification' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 73  ? LEU A 75  ? VAL A 73  LEU A 75  
AA1 2 PHE A 66  ? ALA A 70  ? PHE A 66  ALA A 70  
AA1 3 MET A 17  ? CYS A 22  ? MET A 17  CYS A 22  
AA1 4 THR A 25  ? LEU A 32  ? THR A 25  LEU A 32  
AA1 5 VAL A 35  ? PRO A 39  ? VAL A 35  PRO A 39  
AA1 6 VAL A 86  ? VAL A 91  ? VAL A 86  VAL A 91  
AA1 7 VAL A 77  ? GLN A 83  ? VAL A 77  GLN A 83  
AA2 1 LYS A 100 ? PHE A 103 ? LYS A 100 PHE A 103 
AA2 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA2 3 VAL A 148 ? ASP A 153 ? VAL A 148 ASP A 153 
AA2 4 THR A 111 ? TYR A 118 ? THR A 111 TYR A 118 
AA2 5 SER A 121 ? ALA A 129 ? SER A 121 ALA A 129 
AA3 1 LYS A 100 ? PHE A 103 ? LYS A 100 PHE A 103 
AA3 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA3 3 HIS A 172 ? THR A 175 ? HIS A 172 THR A 175 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL A 73  ? O VAL A 73  N ALA A 70  ? N ALA A 70  
AA1 2 3 O LEU A 67  ? O LEU A 67  N THR A 21  ? N THR A 21  
AA1 3 4 N VAL A 20  ? N VAL A 20  O LEU A 27  ? O LEU A 27  
AA1 4 5 N LEU A 30  ? N LEU A 30  O TYR A 37  ? O TYR A 37  
AA1 5 6 N CYS A 38  ? N CYS A 38  O LEU A 87  ? O LEU A 87  
AA1 6 7 O LYS A 90  ? O LYS A 90  N ILE A 78  ? N ILE A 78  
AA2 1 2 N LYS A 100 ? N LYS A 100 O VAL A 157 ? O VAL A 157 
AA2 2 3 O CYS A 156 ? O CYS A 156 N ASP A 153 ? N ASP A 153 
AA2 3 4 O PHE A 150 ? O PHE A 150 N SER A 113 ? N SER A 113 
AA2 4 5 N VAL A 114 ? N VAL A 114 O TYR A 126 ? O TYR A 126 
AA3 1 2 N LYS A 100 ? N LYS A 100 O VAL A 157 ? O VAL A 157 
AA3 2 3 N MET A 162 ? N MET A 162 O THR A 175 ? O THR A 175 
# 
_pdbx_entry_details.entry_id                   9BVZ 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 O   A HOH 502 ? ? O A HOH 528 ? ? 1.94 
2  1 O   A ALA 194 ? ? O A HOH 501 ? ? 1.96 
3  1 O   A HOH 562 ? ? O A HOH 637 ? ? 2.03 
4  1 O   A HOH 560 ? ? O A HOH 644 ? ? 2.04 
5  1 O   A HOH 558 ? ? O A HOH 645 ? ? 2.08 
6  1 NZ  A LYS 88  ? ? O A HOH 502 ? ? 2.10 
7  1 O   A HOH 610 ? ? O A HOH 640 ? ? 2.10 
8  1 ND2 A ASN 95  ? ? O A HOH 503 ? ? 2.11 
9  1 O   A SER 62  ? ? O A HOH 504 ? ? 2.11 
10 1 O   A ARG 279 ? ? O A HOH 505 ? ? 2.11 
11 1 N   A THR 169 ? ? O A HOH 506 ? ? 2.11 
12 1 OG  A SER 121 ? ? O A HOH 507 ? ? 2.11 
13 1 O   A SER 301 ? ? O A HOH 508 ? ? 2.11 
14 1 SD  A MET 49  ? ? O A HOH 566 ? ? 2.11 
15 1 O   A PHE 150 ? ? O A HOH 509 ? ? 2.12 
16 1 OD2 A ASP 153 ? ? O A HOH 510 ? ? 2.12 
17 1 O   A HOH 644 ? ? O A HOH 650 ? ? 2.13 
18 1 O   A HOH 582 ? ? O A HOH 587 ? ? 2.13 
19 1 O   A HOH 655 ? ? O A HOH 662 ? ? 2.16 
20 1 O   A HOH 529 ? ? O A HOH 624 ? ? 2.17 
21 1 OE2 A GLU 288 ? ? O A HOH 511 ? ? 2.17 
22 1 N   A GLY 195 ? ? O A HOH 512 ? ? 2.18 
23 1 ND2 A ASN 180 ? ? O A HOH 513 ? ? 2.19 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    O 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    HOH 
_pdbx_validate_symm_contact.auth_seq_id_1     629 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O 
_pdbx_validate_symm_contact.auth_asym_id_2    A 
_pdbx_validate_symm_contact.auth_comp_id_2    HOH 
_pdbx_validate_symm_contact.auth_seq_id_2     652 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   2_555 
_pdbx_validate_symm_contact.dist              2.07 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             CD 
_pdbx_validate_rmsd_angle.auth_asym_id_1             A 
_pdbx_validate_rmsd_angle.auth_comp_id_1             LYS 
_pdbx_validate_rmsd_angle.auth_seq_id_1              5 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CE 
_pdbx_validate_rmsd_angle.auth_asym_id_2             A 
_pdbx_validate_rmsd_angle.auth_comp_id_2             LYS 
_pdbx_validate_rmsd_angle.auth_seq_id_2              5 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             NZ 
_pdbx_validate_rmsd_angle.auth_asym_id_3             A 
_pdbx_validate_rmsd_angle.auth_comp_id_3             LYS 
_pdbx_validate_rmsd_angle.auth_seq_id_3              5 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                94.96 
_pdbx_validate_rmsd_angle.angle_target_value         111.70 
_pdbx_validate_rmsd_angle.angle_deviation            -16.74 
_pdbx_validate_rmsd_angle.angle_standard_deviation   2.30 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 33  ? ? 57.19   -129.56 
2 1 MET A 49  ? ? -54.27  7.34    
3 1 LEU A 50  ? ? -92.16  -81.34  
4 1 ASN A 84  ? ? 55.50   -123.70 
5 1 TYR A 154 ? ? 45.05   -95.71  
6 1 THR A 169 ? ? -68.22  9.65    
7 1 SER A 301 ? ? -142.28 -64.84  
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 556 ? C HOH . 
2 1 A HOH 571 ? C HOH . 
3 1 A HOH 606 ? C HOH . 
4 1 A HOH 656 ? C HOH . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z               
2 -x,y,-z             
3 x+1/2,y+1/2,z+1/2   
4 -x+1/2,y+1/2,-z+1/2 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1AS4 N1   N Y N 1   
A1AS4 C4   C Y N 2   
A1AS4 C5   C Y N 3   
A1AS4 C6   C N N 4   
A1AS4 B1   B N N 5   
A1AS4 C1   C Y N 6   
A1AS4 C2   C Y N 7   
A1AS4 C3   C Y N 8   
A1AS4 N2   N N N 9   
A1AS4 O1   O N N 10  
A1AS4 O2   O N N 11  
A1AS4 H4   H N N 12  
A1AS4 H1   H N N 13  
A1AS4 H2   H N N 14  
A1AS4 H3   H N N 15  
A1AS4 H5   H N N 16  
A1AS4 H6   H N N 17  
A1AS4 H7   H N N 18  
ALA   N    N N N 19  
ALA   CA   C N S 20  
ALA   C    C N N 21  
ALA   O    O N N 22  
ALA   CB   C N N 23  
ALA   OXT  O N N 24  
ALA   H    H N N 25  
ALA   H2   H N N 26  
ALA   HA   H N N 27  
ALA   HB1  H N N 28  
ALA   HB2  H N N 29  
ALA   HB3  H N N 30  
ALA   HXT  H N N 31  
ARG   N    N N N 32  
ARG   CA   C N S 33  
ARG   C    C N N 34  
ARG   O    O N N 35  
ARG   CB   C N N 36  
ARG   CG   C N N 37  
ARG   CD   C N N 38  
ARG   NE   N N N 39  
ARG   CZ   C N N 40  
ARG   NH1  N N N 41  
ARG   NH2  N N N 42  
ARG   OXT  O N N 43  
ARG   H    H N N 44  
ARG   H2   H N N 45  
ARG   HA   H N N 46  
ARG   HB2  H N N 47  
ARG   HB3  H N N 48  
ARG   HG2  H N N 49  
ARG   HG3  H N N 50  
ARG   HD2  H N N 51  
ARG   HD3  H N N 52  
ARG   HE   H N N 53  
ARG   HH11 H N N 54  
ARG   HH12 H N N 55  
ARG   HH21 H N N 56  
ARG   HH22 H N N 57  
ARG   HXT  H N N 58  
ASN   N    N N N 59  
ASN   CA   C N S 60  
ASN   C    C N N 61  
ASN   O    O N N 62  
ASN   CB   C N N 63  
ASN   CG   C N N 64  
ASN   OD1  O N N 65  
ASN   ND2  N N N 66  
ASN   OXT  O N N 67  
ASN   H    H N N 68  
ASN   H2   H N N 69  
ASN   HA   H N N 70  
ASN   HB2  H N N 71  
ASN   HB3  H N N 72  
ASN   HD21 H N N 73  
ASN   HD22 H N N 74  
ASN   HXT  H N N 75  
ASP   N    N N N 76  
ASP   CA   C N S 77  
ASP   C    C N N 78  
ASP   O    O N N 79  
ASP   CB   C N N 80  
ASP   CG   C N N 81  
ASP   OD1  O N N 82  
ASP   OD2  O N N 83  
ASP   OXT  O N N 84  
ASP   H    H N N 85  
ASP   H2   H N N 86  
ASP   HA   H N N 87  
ASP   HB2  H N N 88  
ASP   HB3  H N N 89  
ASP   HD2  H N N 90  
ASP   HXT  H N N 91  
CYS   N    N N N 92  
CYS   CA   C N R 93  
CYS   C    C N N 94  
CYS   O    O N N 95  
CYS   CB   C N N 96  
CYS   SG   S N N 97  
CYS   OXT  O N N 98  
CYS   H    H N N 99  
CYS   H2   H N N 100 
CYS   HA   H N N 101 
CYS   HB2  H N N 102 
CYS   HB3  H N N 103 
CYS   HG   H N N 104 
CYS   HXT  H N N 105 
GLN   N    N N N 106 
GLN   CA   C N S 107 
GLN   C    C N N 108 
GLN   O    O N N 109 
GLN   CB   C N N 110 
GLN   CG   C N N 111 
GLN   CD   C N N 112 
GLN   OE1  O N N 113 
GLN   NE2  N N N 114 
GLN   OXT  O N N 115 
GLN   H    H N N 116 
GLN   H2   H N N 117 
GLN   HA   H N N 118 
GLN   HB2  H N N 119 
GLN   HB3  H N N 120 
GLN   HG2  H N N 121 
GLN   HG3  H N N 122 
GLN   HE21 H N N 123 
GLN   HE22 H N N 124 
GLN   HXT  H N N 125 
GLU   N    N N N 126 
GLU   CA   C N S 127 
GLU   C    C N N 128 
GLU   O    O N N 129 
GLU   CB   C N N 130 
GLU   CG   C N N 131 
GLU   CD   C N N 132 
GLU   OE1  O N N 133 
GLU   OE2  O N N 134 
GLU   OXT  O N N 135 
GLU   H    H N N 136 
GLU   H2   H N N 137 
GLU   HA   H N N 138 
GLU   HB2  H N N 139 
GLU   HB3  H N N 140 
GLU   HG2  H N N 141 
GLU   HG3  H N N 142 
GLU   HE2  H N N 143 
GLU   HXT  H N N 144 
GLY   N    N N N 145 
GLY   CA   C N N 146 
GLY   C    C N N 147 
GLY   O    O N N 148 
GLY   OXT  O N N 149 
GLY   H    H N N 150 
GLY   H2   H N N 151 
GLY   HA2  H N N 152 
GLY   HA3  H N N 153 
GLY   HXT  H N N 154 
HIS   N    N N N 155 
HIS   CA   C N S 156 
HIS   C    C N N 157 
HIS   O    O N N 158 
HIS   CB   C N N 159 
HIS   CG   C Y N 160 
HIS   ND1  N Y N 161 
HIS   CD2  C Y N 162 
HIS   CE1  C Y N 163 
HIS   NE2  N Y N 164 
HIS   OXT  O N N 165 
HIS   H    H N N 166 
HIS   H2   H N N 167 
HIS   HA   H N N 168 
HIS   HB2  H N N 169 
HIS   HB3  H N N 170 
HIS   HD1  H N N 171 
HIS   HD2  H N N 172 
HIS   HE1  H N N 173 
HIS   HE2  H N N 174 
HIS   HXT  H N N 175 
HOH   O    O N N 176 
HOH   H1   H N N 177 
HOH   H2   H N N 178 
ILE   N    N N N 179 
ILE   CA   C N S 180 
ILE   C    C N N 181 
ILE   O    O N N 182 
ILE   CB   C N S 183 
ILE   CG1  C N N 184 
ILE   CG2  C N N 185 
ILE   CD1  C N N 186 
ILE   OXT  O N N 187 
ILE   H    H N N 188 
ILE   H2   H N N 189 
ILE   HA   H N N 190 
ILE   HB   H N N 191 
ILE   HG12 H N N 192 
ILE   HG13 H N N 193 
ILE   HG21 H N N 194 
ILE   HG22 H N N 195 
ILE   HG23 H N N 196 
ILE   HD11 H N N 197 
ILE   HD12 H N N 198 
ILE   HD13 H N N 199 
ILE   HXT  H N N 200 
LEU   N    N N N 201 
LEU   CA   C N S 202 
LEU   C    C N N 203 
LEU   O    O N N 204 
LEU   CB   C N N 205 
LEU   CG   C N N 206 
LEU   CD1  C N N 207 
LEU   CD2  C N N 208 
LEU   OXT  O N N 209 
LEU   H    H N N 210 
LEU   H2   H N N 211 
LEU   HA   H N N 212 
LEU   HB2  H N N 213 
LEU   HB3  H N N 214 
LEU   HG   H N N 215 
LEU   HD11 H N N 216 
LEU   HD12 H N N 217 
LEU   HD13 H N N 218 
LEU   HD21 H N N 219 
LEU   HD22 H N N 220 
LEU   HD23 H N N 221 
LEU   HXT  H N N 222 
LYS   N    N N N 223 
LYS   CA   C N S 224 
LYS   C    C N N 225 
LYS   O    O N N 226 
LYS   CB   C N N 227 
LYS   CG   C N N 228 
LYS   CD   C N N 229 
LYS   CE   C N N 230 
LYS   NZ   N N N 231 
LYS   OXT  O N N 232 
LYS   H    H N N 233 
LYS   H2   H N N 234 
LYS   HA   H N N 235 
LYS   HB2  H N N 236 
LYS   HB3  H N N 237 
LYS   HG2  H N N 238 
LYS   HG3  H N N 239 
LYS   HD2  H N N 240 
LYS   HD3  H N N 241 
LYS   HE2  H N N 242 
LYS   HE3  H N N 243 
LYS   HZ1  H N N 244 
LYS   HZ2  H N N 245 
LYS   HZ3  H N N 246 
LYS   HXT  H N N 247 
MET   N    N N N 248 
MET   CA   C N S 249 
MET   C    C N N 250 
MET   O    O N N 251 
MET   CB   C N N 252 
MET   CG   C N N 253 
MET   SD   S N N 254 
MET   CE   C N N 255 
MET   OXT  O N N 256 
MET   H    H N N 257 
MET   H2   H N N 258 
MET   HA   H N N 259 
MET   HB2  H N N 260 
MET   HB3  H N N 261 
MET   HG2  H N N 262 
MET   HG3  H N N 263 
MET   HE1  H N N 264 
MET   HE2  H N N 265 
MET   HE3  H N N 266 
MET   HXT  H N N 267 
PHE   N    N N N 268 
PHE   CA   C N S 269 
PHE   C    C N N 270 
PHE   O    O N N 271 
PHE   CB   C N N 272 
PHE   CG   C Y N 273 
PHE   CD1  C Y N 274 
PHE   CD2  C Y N 275 
PHE   CE1  C Y N 276 
PHE   CE2  C Y N 277 
PHE   CZ   C Y N 278 
PHE   OXT  O N N 279 
PHE   H    H N N 280 
PHE   H2   H N N 281 
PHE   HA   H N N 282 
PHE   HB2  H N N 283 
PHE   HB3  H N N 284 
PHE   HD1  H N N 285 
PHE   HD2  H N N 286 
PHE   HE1  H N N 287 
PHE   HE2  H N N 288 
PHE   HZ   H N N 289 
PHE   HXT  H N N 290 
PRO   N    N N N 291 
PRO   CA   C N S 292 
PRO   C    C N N 293 
PRO   O    O N N 294 
PRO   CB   C N N 295 
PRO   CG   C N N 296 
PRO   CD   C N N 297 
PRO   OXT  O N N 298 
PRO   H    H N N 299 
PRO   HA   H N N 300 
PRO   HB2  H N N 301 
PRO   HB3  H N N 302 
PRO   HG2  H N N 303 
PRO   HG3  H N N 304 
PRO   HD2  H N N 305 
PRO   HD3  H N N 306 
PRO   HXT  H N N 307 
SER   N    N N N 308 
SER   CA   C N S 309 
SER   C    C N N 310 
SER   O    O N N 311 
SER   CB   C N N 312 
SER   OG   O N N 313 
SER   OXT  O N N 314 
SER   H    H N N 315 
SER   H2   H N N 316 
SER   HA   H N N 317 
SER   HB2  H N N 318 
SER   HB3  H N N 319 
SER   HG   H N N 320 
SER   HXT  H N N 321 
THR   N    N N N 322 
THR   CA   C N S 323 
THR   C    C N N 324 
THR   O    O N N 325 
THR   CB   C N R 326 
THR   OG1  O N N 327 
THR   CG2  C N N 328 
THR   OXT  O N N 329 
THR   H    H N N 330 
THR   H2   H N N 331 
THR   HA   H N N 332 
THR   HB   H N N 333 
THR   HG1  H N N 334 
THR   HG21 H N N 335 
THR   HG22 H N N 336 
THR   HG23 H N N 337 
THR   HXT  H N N 338 
TRP   N    N N N 339 
TRP   CA   C N S 340 
TRP   C    C N N 341 
TRP   O    O N N 342 
TRP   CB   C N N 343 
TRP   CG   C Y N 344 
TRP   CD1  C Y N 345 
TRP   CD2  C Y N 346 
TRP   NE1  N Y N 347 
TRP   CE2  C Y N 348 
TRP   CE3  C Y N 349 
TRP   CZ2  C Y N 350 
TRP   CZ3  C Y N 351 
TRP   CH2  C Y N 352 
TRP   OXT  O N N 353 
TRP   H    H N N 354 
TRP   H2   H N N 355 
TRP   HA   H N N 356 
TRP   HB2  H N N 357 
TRP   HB3  H N N 358 
TRP   HD1  H N N 359 
TRP   HE1  H N N 360 
TRP   HE3  H N N 361 
TRP   HZ2  H N N 362 
TRP   HZ3  H N N 363 
TRP   HH2  H N N 364 
TRP   HXT  H N N 365 
TYR   N    N N N 366 
TYR   CA   C N S 367 
TYR   C    C N N 368 
TYR   O    O N N 369 
TYR   CB   C N N 370 
TYR   CG   C Y N 371 
TYR   CD1  C Y N 372 
TYR   CD2  C Y N 373 
TYR   CE1  C Y N 374 
TYR   CE2  C Y N 375 
TYR   CZ   C Y N 376 
TYR   OH   O N N 377 
TYR   OXT  O N N 378 
TYR   H    H N N 379 
TYR   H2   H N N 380 
TYR   HA   H N N 381 
TYR   HB2  H N N 382 
TYR   HB3  H N N 383 
TYR   HD1  H N N 384 
TYR   HD2  H N N 385 
TYR   HE1  H N N 386 
TYR   HE2  H N N 387 
TYR   HH   H N N 388 
TYR   HXT  H N N 389 
VAL   N    N N N 390 
VAL   CA   C N S 391 
VAL   C    C N N 392 
VAL   O    O N N 393 
VAL   CB   C N N 394 
VAL   CG1  C N N 395 
VAL   CG2  C N N 396 
VAL   OXT  O N N 397 
VAL   H    H N N 398 
VAL   H2   H N N 399 
VAL   HA   H N N 400 
VAL   HB   H N N 401 
VAL   HG11 H N N 402 
VAL   HG12 H N N 403 
VAL   HG13 H N N 404 
VAL   HG21 H N N 405 
VAL   HG22 H N N 406 
VAL   HG23 H N N 407 
VAL   HXT  H N N 408 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1AS4 C1  C2   doub Y N 1   
A1AS4 C1  N1   sing Y N 2   
A1AS4 C2  C3   sing Y N 3   
A1AS4 C3  C4   doub Y N 4   
A1AS4 C4  C5   sing Y N 5   
A1AS4 C4  B1   sing N N 6   
A1AS4 C5  N1   doub Y N 7   
A1AS4 C5  C6   sing N N 8   
A1AS4 C6  N2   doub N N 9   
A1AS4 B1  O1   sing N N 10  
A1AS4 B1  O2   sing N N 11  
A1AS4 C6  H4   sing N N 12  
A1AS4 C1  H1   sing N N 13  
A1AS4 C2  H2   sing N N 14  
A1AS4 C3  H3   sing N N 15  
A1AS4 N2  H5   sing N N 16  
A1AS4 O1  H6   sing N N 17  
A1AS4 O2  H7   sing N N 18  
ALA   N   CA   sing N N 19  
ALA   N   H    sing N N 20  
ALA   N   H2   sing N N 21  
ALA   CA  C    sing N N 22  
ALA   CA  CB   sing N N 23  
ALA   CA  HA   sing N N 24  
ALA   C   O    doub N N 25  
ALA   C   OXT  sing N N 26  
ALA   CB  HB1  sing N N 27  
ALA   CB  HB2  sing N N 28  
ALA   CB  HB3  sing N N 29  
ALA   OXT HXT  sing N N 30  
ARG   N   CA   sing N N 31  
ARG   N   H    sing N N 32  
ARG   N   H2   sing N N 33  
ARG   CA  C    sing N N 34  
ARG   CA  CB   sing N N 35  
ARG   CA  HA   sing N N 36  
ARG   C   O    doub N N 37  
ARG   C   OXT  sing N N 38  
ARG   CB  CG   sing N N 39  
ARG   CB  HB2  sing N N 40  
ARG   CB  HB3  sing N N 41  
ARG   CG  CD   sing N N 42  
ARG   CG  HG2  sing N N 43  
ARG   CG  HG3  sing N N 44  
ARG   CD  NE   sing N N 45  
ARG   CD  HD2  sing N N 46  
ARG   CD  HD3  sing N N 47  
ARG   NE  CZ   sing N N 48  
ARG   NE  HE   sing N N 49  
ARG   CZ  NH1  sing N N 50  
ARG   CZ  NH2  doub N N 51  
ARG   NH1 HH11 sing N N 52  
ARG   NH1 HH12 sing N N 53  
ARG   NH2 HH21 sing N N 54  
ARG   NH2 HH22 sing N N 55  
ARG   OXT HXT  sing N N 56  
ASN   N   CA   sing N N 57  
ASN   N   H    sing N N 58  
ASN   N   H2   sing N N 59  
ASN   CA  C    sing N N 60  
ASN   CA  CB   sing N N 61  
ASN   CA  HA   sing N N 62  
ASN   C   O    doub N N 63  
ASN   C   OXT  sing N N 64  
ASN   CB  CG   sing N N 65  
ASN   CB  HB2  sing N N 66  
ASN   CB  HB3  sing N N 67  
ASN   CG  OD1  doub N N 68  
ASN   CG  ND2  sing N N 69  
ASN   ND2 HD21 sing N N 70  
ASN   ND2 HD22 sing N N 71  
ASN   OXT HXT  sing N N 72  
ASP   N   CA   sing N N 73  
ASP   N   H    sing N N 74  
ASP   N   H2   sing N N 75  
ASP   CA  C    sing N N 76  
ASP   CA  CB   sing N N 77  
ASP   CA  HA   sing N N 78  
ASP   C   O    doub N N 79  
ASP   C   OXT  sing N N 80  
ASP   CB  CG   sing N N 81  
ASP   CB  HB2  sing N N 82  
ASP   CB  HB3  sing N N 83  
ASP   CG  OD1  doub N N 84  
ASP   CG  OD2  sing N N 85  
ASP   OD2 HD2  sing N N 86  
ASP   OXT HXT  sing N N 87  
CYS   N   CA   sing N N 88  
CYS   N   H    sing N N 89  
CYS   N   H2   sing N N 90  
CYS   CA  C    sing N N 91  
CYS   CA  CB   sing N N 92  
CYS   CA  HA   sing N N 93  
CYS   C   O    doub N N 94  
CYS   C   OXT  sing N N 95  
CYS   CB  SG   sing N N 96  
CYS   CB  HB2  sing N N 97  
CYS   CB  HB3  sing N N 98  
CYS   SG  HG   sing N N 99  
CYS   OXT HXT  sing N N 100 
GLN   N   CA   sing N N 101 
GLN   N   H    sing N N 102 
GLN   N   H2   sing N N 103 
GLN   CA  C    sing N N 104 
GLN   CA  CB   sing N N 105 
GLN   CA  HA   sing N N 106 
GLN   C   O    doub N N 107 
GLN   C   OXT  sing N N 108 
GLN   CB  CG   sing N N 109 
GLN   CB  HB2  sing N N 110 
GLN   CB  HB3  sing N N 111 
GLN   CG  CD   sing N N 112 
GLN   CG  HG2  sing N N 113 
GLN   CG  HG3  sing N N 114 
GLN   CD  OE1  doub N N 115 
GLN   CD  NE2  sing N N 116 
GLN   NE2 HE21 sing N N 117 
GLN   NE2 HE22 sing N N 118 
GLN   OXT HXT  sing N N 119 
GLU   N   CA   sing N N 120 
GLU   N   H    sing N N 121 
GLU   N   H2   sing N N 122 
GLU   CA  C    sing N N 123 
GLU   CA  CB   sing N N 124 
GLU   CA  HA   sing N N 125 
GLU   C   O    doub N N 126 
GLU   C   OXT  sing N N 127 
GLU   CB  CG   sing N N 128 
GLU   CB  HB2  sing N N 129 
GLU   CB  HB3  sing N N 130 
GLU   CG  CD   sing N N 131 
GLU   CG  HG2  sing N N 132 
GLU   CG  HG3  sing N N 133 
GLU   CD  OE1  doub N N 134 
GLU   CD  OE2  sing N N 135 
GLU   OE2 HE2  sing N N 136 
GLU   OXT HXT  sing N N 137 
GLY   N   CA   sing N N 138 
GLY   N   H    sing N N 139 
GLY   N   H2   sing N N 140 
GLY   CA  C    sing N N 141 
GLY   CA  HA2  sing N N 142 
GLY   CA  HA3  sing N N 143 
GLY   C   O    doub N N 144 
GLY   C   OXT  sing N N 145 
GLY   OXT HXT  sing N N 146 
HIS   N   CA   sing N N 147 
HIS   N   H    sing N N 148 
HIS   N   H2   sing N N 149 
HIS   CA  C    sing N N 150 
HIS   CA  CB   sing N N 151 
HIS   CA  HA   sing N N 152 
HIS   C   O    doub N N 153 
HIS   C   OXT  sing N N 154 
HIS   CB  CG   sing N N 155 
HIS   CB  HB2  sing N N 156 
HIS   CB  HB3  sing N N 157 
HIS   CG  ND1  sing Y N 158 
HIS   CG  CD2  doub Y N 159 
HIS   ND1 CE1  doub Y N 160 
HIS   ND1 HD1  sing N N 161 
HIS   CD2 NE2  sing Y N 162 
HIS   CD2 HD2  sing N N 163 
HIS   CE1 NE2  sing Y N 164 
HIS   CE1 HE1  sing N N 165 
HIS   NE2 HE2  sing N N 166 
HIS   OXT HXT  sing N N 167 
HOH   O   H1   sing N N 168 
HOH   O   H2   sing N N 169 
ILE   N   CA   sing N N 170 
ILE   N   H    sing N N 171 
ILE   N   H2   sing N N 172 
ILE   CA  C    sing N N 173 
ILE   CA  CB   sing N N 174 
ILE   CA  HA   sing N N 175 
ILE   C   O    doub N N 176 
ILE   C   OXT  sing N N 177 
ILE   CB  CG1  sing N N 178 
ILE   CB  CG2  sing N N 179 
ILE   CB  HB   sing N N 180 
ILE   CG1 CD1  sing N N 181 
ILE   CG1 HG12 sing N N 182 
ILE   CG1 HG13 sing N N 183 
ILE   CG2 HG21 sing N N 184 
ILE   CG2 HG22 sing N N 185 
ILE   CG2 HG23 sing N N 186 
ILE   CD1 HD11 sing N N 187 
ILE   CD1 HD12 sing N N 188 
ILE   CD1 HD13 sing N N 189 
ILE   OXT HXT  sing N N 190 
LEU   N   CA   sing N N 191 
LEU   N   H    sing N N 192 
LEU   N   H2   sing N N 193 
LEU   CA  C    sing N N 194 
LEU   CA  CB   sing N N 195 
LEU   CA  HA   sing N N 196 
LEU   C   O    doub N N 197 
LEU   C   OXT  sing N N 198 
LEU   CB  CG   sing N N 199 
LEU   CB  HB2  sing N N 200 
LEU   CB  HB3  sing N N 201 
LEU   CG  CD1  sing N N 202 
LEU   CG  CD2  sing N N 203 
LEU   CG  HG   sing N N 204 
LEU   CD1 HD11 sing N N 205 
LEU   CD1 HD12 sing N N 206 
LEU   CD1 HD13 sing N N 207 
LEU   CD2 HD21 sing N N 208 
LEU   CD2 HD22 sing N N 209 
LEU   CD2 HD23 sing N N 210 
LEU   OXT HXT  sing N N 211 
LYS   N   CA   sing N N 212 
LYS   N   H    sing N N 213 
LYS   N   H2   sing N N 214 
LYS   CA  C    sing N N 215 
LYS   CA  CB   sing N N 216 
LYS   CA  HA   sing N N 217 
LYS   C   O    doub N N 218 
LYS   C   OXT  sing N N 219 
LYS   CB  CG   sing N N 220 
LYS   CB  HB2  sing N N 221 
LYS   CB  HB3  sing N N 222 
LYS   CG  CD   sing N N 223 
LYS   CG  HG2  sing N N 224 
LYS   CG  HG3  sing N N 225 
LYS   CD  CE   sing N N 226 
LYS   CD  HD2  sing N N 227 
LYS   CD  HD3  sing N N 228 
LYS   CE  NZ   sing N N 229 
LYS   CE  HE2  sing N N 230 
LYS   CE  HE3  sing N N 231 
LYS   NZ  HZ1  sing N N 232 
LYS   NZ  HZ2  sing N N 233 
LYS   NZ  HZ3  sing N N 234 
LYS   OXT HXT  sing N N 235 
MET   N   CA   sing N N 236 
MET   N   H    sing N N 237 
MET   N   H2   sing N N 238 
MET   CA  C    sing N N 239 
MET   CA  CB   sing N N 240 
MET   CA  HA   sing N N 241 
MET   C   O    doub N N 242 
MET   C   OXT  sing N N 243 
MET   CB  CG   sing N N 244 
MET   CB  HB2  sing N N 245 
MET   CB  HB3  sing N N 246 
MET   CG  SD   sing N N 247 
MET   CG  HG2  sing N N 248 
MET   CG  HG3  sing N N 249 
MET   SD  CE   sing N N 250 
MET   CE  HE1  sing N N 251 
MET   CE  HE2  sing N N 252 
MET   CE  HE3  sing N N 253 
MET   OXT HXT  sing N N 254 
PHE   N   CA   sing N N 255 
PHE   N   H    sing N N 256 
PHE   N   H2   sing N N 257 
PHE   CA  C    sing N N 258 
PHE   CA  CB   sing N N 259 
PHE   CA  HA   sing N N 260 
PHE   C   O    doub N N 261 
PHE   C   OXT  sing N N 262 
PHE   CB  CG   sing N N 263 
PHE   CB  HB2  sing N N 264 
PHE   CB  HB3  sing N N 265 
PHE   CG  CD1  doub Y N 266 
PHE   CG  CD2  sing Y N 267 
PHE   CD1 CE1  sing Y N 268 
PHE   CD1 HD1  sing N N 269 
PHE   CD2 CE2  doub Y N 270 
PHE   CD2 HD2  sing N N 271 
PHE   CE1 CZ   doub Y N 272 
PHE   CE1 HE1  sing N N 273 
PHE   CE2 CZ   sing Y N 274 
PHE   CE2 HE2  sing N N 275 
PHE   CZ  HZ   sing N N 276 
PHE   OXT HXT  sing N N 277 
PRO   N   CA   sing N N 278 
PRO   N   CD   sing N N 279 
PRO   N   H    sing N N 280 
PRO   CA  C    sing N N 281 
PRO   CA  CB   sing N N 282 
PRO   CA  HA   sing N N 283 
PRO   C   O    doub N N 284 
PRO   C   OXT  sing N N 285 
PRO   CB  CG   sing N N 286 
PRO   CB  HB2  sing N N 287 
PRO   CB  HB3  sing N N 288 
PRO   CG  CD   sing N N 289 
PRO   CG  HG2  sing N N 290 
PRO   CG  HG3  sing N N 291 
PRO   CD  HD2  sing N N 292 
PRO   CD  HD3  sing N N 293 
PRO   OXT HXT  sing N N 294 
SER   N   CA   sing N N 295 
SER   N   H    sing N N 296 
SER   N   H2   sing N N 297 
SER   CA  C    sing N N 298 
SER   CA  CB   sing N N 299 
SER   CA  HA   sing N N 300 
SER   C   O    doub N N 301 
SER   C   OXT  sing N N 302 
SER   CB  OG   sing N N 303 
SER   CB  HB2  sing N N 304 
SER   CB  HB3  sing N N 305 
SER   OG  HG   sing N N 306 
SER   OXT HXT  sing N N 307 
THR   N   CA   sing N N 308 
THR   N   H    sing N N 309 
THR   N   H2   sing N N 310 
THR   CA  C    sing N N 311 
THR   CA  CB   sing N N 312 
THR   CA  HA   sing N N 313 
THR   C   O    doub N N 314 
THR   C   OXT  sing N N 315 
THR   CB  OG1  sing N N 316 
THR   CB  CG2  sing N N 317 
THR   CB  HB   sing N N 318 
THR   OG1 HG1  sing N N 319 
THR   CG2 HG21 sing N N 320 
THR   CG2 HG22 sing N N 321 
THR   CG2 HG23 sing N N 322 
THR   OXT HXT  sing N N 323 
TRP   N   CA   sing N N 324 
TRP   N   H    sing N N 325 
TRP   N   H2   sing N N 326 
TRP   CA  C    sing N N 327 
TRP   CA  CB   sing N N 328 
TRP   CA  HA   sing N N 329 
TRP   C   O    doub N N 330 
TRP   C   OXT  sing N N 331 
TRP   CB  CG   sing N N 332 
TRP   CB  HB2  sing N N 333 
TRP   CB  HB3  sing N N 334 
TRP   CG  CD1  doub Y N 335 
TRP   CG  CD2  sing Y N 336 
TRP   CD1 NE1  sing Y N 337 
TRP   CD1 HD1  sing N N 338 
TRP   CD2 CE2  doub Y N 339 
TRP   CD2 CE3  sing Y N 340 
TRP   NE1 CE2  sing Y N 341 
TRP   NE1 HE1  sing N N 342 
TRP   CE2 CZ2  sing Y N 343 
TRP   CE3 CZ3  doub Y N 344 
TRP   CE3 HE3  sing N N 345 
TRP   CZ2 CH2  doub Y N 346 
TRP   CZ2 HZ2  sing N N 347 
TRP   CZ3 CH2  sing Y N 348 
TRP   CZ3 HZ3  sing N N 349 
TRP   CH2 HH2  sing N N 350 
TRP   OXT HXT  sing N N 351 
TYR   N   CA   sing N N 352 
TYR   N   H    sing N N 353 
TYR   N   H2   sing N N 354 
TYR   CA  C    sing N N 355 
TYR   CA  CB   sing N N 356 
TYR   CA  HA   sing N N 357 
TYR   C   O    doub N N 358 
TYR   C   OXT  sing N N 359 
TYR   CB  CG   sing N N 360 
TYR   CB  HB2  sing N N 361 
TYR   CB  HB3  sing N N 362 
TYR   CG  CD1  doub Y N 363 
TYR   CG  CD2  sing Y N 364 
TYR   CD1 CE1  sing Y N 365 
TYR   CD1 HD1  sing N N 366 
TYR   CD2 CE2  doub Y N 367 
TYR   CD2 HD2  sing N N 368 
TYR   CE1 CZ   doub Y N 369 
TYR   CE1 HE1  sing N N 370 
TYR   CE2 CZ   sing Y N 371 
TYR   CE2 HE2  sing N N 372 
TYR   CZ  OH   sing N N 373 
TYR   OH  HH   sing N N 374 
TYR   OXT HXT  sing N N 375 
VAL   N   CA   sing N N 376 
VAL   N   H    sing N N 377 
VAL   N   H2   sing N N 378 
VAL   CA  C    sing N N 379 
VAL   CA  CB   sing N N 380 
VAL   CA  HA   sing N N 381 
VAL   C   O    doub N N 382 
VAL   C   OXT  sing N N 383 
VAL   CB  CG1  sing N N 384 
VAL   CB  CG2  sing N N 385 
VAL   CB  HB   sing N N 386 
VAL   CG1 HG11 sing N N 387 
VAL   CG1 HG12 sing N N 388 
VAL   CG1 HG13 sing N N 389 
VAL   CG2 HG21 sing N N 390 
VAL   CG2 HG22 sing N N 391 
VAL   CG2 HG23 sing N N 392 
VAL   OXT HXT  sing N N 393 
# 
_pdbx_audit_support.funding_organization   'Welch Foundation' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7JPY 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'I 1 2 1' 
_space_group.name_Hall        'C 2y (x,y,-x+z)' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9BVZ 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.019245 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.002118 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.012243 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.011016 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
B ? ? 2.74417 2.23879 ? ? 37.84921 1.85376  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . SER   A 1 1   ? -33.28526 -18.54644 15.41790  1.000 12.91171 ? 1   SER   A N   1 
ATOM   2    C CA  . SER   A 1 1   ? -32.45546 -19.62780 14.91258  1.000 18.42573 ? 1   SER   A CA  1 
ATOM   3    C C   . SER   A 1 1   ? -32.47970 -19.74326 13.38310  1.000 13.88265 ? 1   SER   A C   1 
ATOM   4    O O   . SER   A 1 1   ? -32.95333 -18.84658 12.67427  1.000 17.97103 ? 1   SER   A O   1 
ATOM   5    C CB  . SER   A 1 1   ? -32.87983 -20.95142 15.55044  1.000 14.08090 ? 1   SER   A CB  1 
ATOM   6    O OG  . SER   A 1 1   ? -34.10315 -21.40563 14.98974  1.000 19.26122 ? 1   SER   A OG  1 
ATOM   7    N N   . GLY   A 1 2   ? -31.95318 -20.85430 12.87967  1.000 24.17723 ? 2   GLY   A N   1 
ATOM   8    C CA  . GLY   A 1 2   ? -31.69408 -21.04454 11.47007  1.000 16.08925 ? 2   GLY   A CA  1 
ATOM   9    C C   . GLY   A 1 2   ? -30.22275 -20.83939 11.14261  1.000 18.59956 ? 2   GLY   A C   1 
ATOM   10   O O   . GLY   A 1 2   ? -29.45876 -20.26142 11.91665  1.000 18.78670 ? 2   GLY   A O   1 
ATOM   11   N N   . PHE   A 1 3   ? -29.81058 -21.34126 9.98615   1.000 20.82106 ? 3   PHE   A N   1 
ATOM   12   C CA  . PHE   A 1 3   ? -28.42037 -21.17858 9.57188   1.000 19.41975 ? 3   PHE   A CA  1 
ATOM   13   C C   . PHE   A 1 3   ? -28.37425 -21.09316 8.06234   1.000 20.45411 ? 3   PHE   A C   1 
ATOM   14   O O   . PHE   A 1 3   ? -28.84259 -22.00920 7.38053   1.000 16.90843 ? 3   PHE   A O   1 
ATOM   15   C CB  . PHE   A 1 3   ? -27.52232 -22.32914 10.04957  1.000 12.87365 ? 3   PHE   A CB  1 
ATOM   16   C CG  . PHE   A 1 3   ? -26.06898 -21.93560 10.18448  1.000 21.50024 ? 3   PHE   A CG  1 
ATOM   17   C CD1 . PHE   A 1 3   ? -25.62049 -21.26066 11.31797  1.000 18.23349 ? 3   PHE   A CD1 1 
ATOM   18   C CD2 . PHE   A 1 3   ? -25.15422 -22.21771 9.17189   1.000 15.32428 ? 3   PHE   A CD2 1 
ATOM   19   C CE1 . PHE   A 1 3   ? -24.27718 -20.87993 11.43981  1.000 18.40174 ? 3   PHE   A CE1 1 
ATOM   20   C CE2 . PHE   A 1 3   ? -23.82305 -21.84207 9.28795   1.000 20.49127 ? 3   PHE   A CE2 1 
ATOM   21   C CZ  . PHE   A 1 3   ? -23.38096 -21.17214 10.42991  1.000 19.40263 ? 3   PHE   A CZ  1 
ATOM   22   N N   . ARG   A 1 4   ? -27.79316 -20.01641 7.54022   1.000 17.36126 ? 4   ARG   A N   1 
ATOM   23   C CA  . ARG   A 1 4   ? -27.75701 -19.89115 6.09500   1.000 17.09054 ? 4   ARG   A CA  1 
ATOM   24   C C   . ARG   A 1 4   ? -26.46155 -19.18855 5.66531   1.000 21.23839 ? 4   ARG   A C   1 
ATOM   25   O O   . ARG   A 1 4   ? -25.79849 -18.53057 6.48237   1.000 11.19666 ? 4   ARG   A O   1 
ATOM   26   C CB  . ARG   A 1 4   ? -29.05286 -19.19713 5.63608   1.000 24.27429 ? 4   ARG   A CB  1 
ATOM   27   C CG  . ARG   A 1 4   ? -29.43087 -19.49184 4.20616   1.000 24.23303 ? 4   ARG   A CG  1 
ATOM   28   C CD  . ARG   A 1 4   ? -30.67339 -18.74989 3.80727   1.000 20.27788 ? 4   ARG   A CD  1 
ATOM   29   N NE  . ARG   A 1 4   ? -31.90347 -19.53879 3.74246   1.000 23.65279 ? 4   ARG   A NE  1 
ATOM   30   C CZ  . ARG   A 1 4   ? -32.15845 -20.44312 2.79463   1.000 24.84101 ? 4   ARG   A CZ  1 
ATOM   31   N NH1 . ARG   A 1 4   ? -31.25745 -20.68735 1.84800   1.000 20.53273 ? 4   ARG   A NH1 1 
ATOM   32   N NH2 . ARG   A 1 4   ? -33.31788 -21.09548 2.78267   1.000 27.01530 ? 4   ARG   A NH2 1 
ATOM   33   N N   . LYS   A 1 5   ? -26.05449 -19.42333 4.39451   1.000 10.29938 ? 5   LYS   A N   1 
ATOM   34   C CA  . LYS   A 1 5   ? -24.94004 -18.68149 3.77735   1.000 18.48395 ? 5   LYS   A CA  1 
ATOM   35   C C   . LYS   A 1 5   ? -25.27829 -17.20629 3.63144   1.000 12.42146 ? 5   LYS   A C   1 
ATOM   36   O O   . LYS   A 1 5   ? -26.15282 -16.82390 2.84519   1.000 28.65819 ? 5   LYS   A O   1 
ATOM   37   C CB  . LYS   A 1 5   ? -24.51946 -19.28816 2.42289   1.000 18.90988 ? 5   LYS   A CB  1 
ATOM   38   C CG  . LYS   A 1 5   ? -23.75623 -20.56954 2.65135   1.000 26.75435 ? 5   LYS   A CG  1 
ATOM   39   C CD  . LYS   A 1 5   ? -22.27138 -20.40662 3.13117   1.000 28.59074 ? 5   LYS   A CD  1 
ATOM   40   C CE  . LYS   A 1 5   ? -21.32178 -20.36658 1.98076   1.000 33.35773 ? 5   LYS   A CE  1 
ATOM   41   N NZ  . LYS   A 1 5   ? -21.57908 -21.81912 1.54523   1.000 15.74837 ? 5   LYS   A NZ  1 
ATOM   42   N N   . MET   A 1 6   ? -24.53626 -16.37310 4.35937   1.000 8.84186  ? 6   MET   A N   1 
ATOM   43   C CA  . MET   A 1 6   ? -24.92257 -14.99013 4.60121   1.000 10.24541 ? 6   MET   A CA  1 
ATOM   44   C C   . MET   A 1 6   ? -23.77352 -14.02276 4.34134   1.000 9.77474  ? 6   MET   A C   1 
ATOM   45   O O   . MET   A 1 6   ? -22.73540 -14.10347 5.00350   1.000 11.35138 ? 6   MET   A O   1 
ATOM   46   C CB  . MET   A 1 6   ? -25.40566 -14.84810 6.04366   1.000 10.83178 ? 6   MET   A CB  1 
ATOM   47   C CG  . MET   A 1 6   ? -25.77040 -13.43481 6.43265   1.000 13.03852 ? 6   MET   A CG  1 
ATOM   48   S SD  . MET   A 1 6   ? -26.40548 -13.32920 8.10536   1.000 32.32671 ? 6   MET   A SD  1 
ATOM   49   C CE  . MET   A 1 6   ? -27.76402 -14.50235 8.01123   1.000 21.08814 ? 6   MET   A CE  1 
ATOM   50   N N   . ALA   A 1 7   ? -23.99779 -13.04242 3.47150   1.000 6.40431  ? 7   ALA   A N   1 
ATOM   51   C CA  . ALA   A 1 7   ? -23.00565 -12.00911 3.22262   1.000 6.82582  ? 7   ALA   A CA  1 
ATOM   52   C C   . ALA   A 1 7   ? -23.22513 -10.76756 4.09186   1.000 9.95229  ? 7   ALA   A C   1 
ATOM   53   O O   . ALA   A 1 7   ? -24.28191 -10.56751 4.68859   1.000 9.07847  ? 7   ALA   A O   1 
ATOM   54   C CB  . ALA   A 1 7   ? -23.01149 -11.59328 1.75824   1.000 5.93499  ? 7   ALA   A CB  1 
ATOM   55   N N   . PHE   A 1 8   ? -22.18023 -9.93869  4.17007   1.000 4.98448  ? 8   PHE   A N   1 
ATOM   56   C CA  . PHE   A 1 8   ? -22.33259 -8.61442  4.72803   1.000 7.59091  ? 8   PHE   A CA  1 
ATOM   57   C C   . PHE   A 1 8   ? -23.19424 -7.76687  3.79442   1.000 6.42902  ? 8   PHE   A C   1 
ATOM   58   O O   . PHE   A 1 8   ? -23.22341 -7.99630  2.58198   1.000 5.78678  ? 8   PHE   A O   1 
ATOM   59   C CB  . PHE   A 1 8   ? -20.96737 -7.94552  4.94667   1.000 4.64728  ? 8   PHE   A CB  1 
ATOM   60   C CG  . PHE   A 1 8   ? -20.13750 -8.63080  5.98632   1.000 11.60592 ? 8   PHE   A CG  1 
ATOM   61   C CD1 . PHE   A 1 8   ? -20.39031 -8.43536  7.33284   1.000 12.01321 ? 8   PHE   A CD1 1 
ATOM   62   C CD2 . PHE   A 1 8   ? -19.12552 -9.48496  5.62644   1.000 10.38923 ? 8   PHE   A CD2 1 
ATOM   63   C CE1 . PHE   A 1 8   ? -19.64372 -9.07762  8.29072   1.000 17.44584 ? 8   PHE   A CE1 1 
ATOM   64   C CE2 . PHE   A 1 8   ? -18.36879 -10.12413 6.58688   1.000 9.89971  ? 8   PHE   A CE2 1 
ATOM   65   C CZ  . PHE   A 1 8   ? -18.62830 -9.92052  7.92525   1.000 18.58463 ? 8   PHE   A CZ  1 
ATOM   66   N N   . PRO   A 1 9   ? -23.93831 -6.81738  4.34820   1.000 7.52204  ? 9   PRO   A N   1 
ATOM   67   C CA  . PRO   A 1 9   ? -24.66727 -5.86748  3.50390   1.000 11.57691 ? 9   PRO   A CA  1 
ATOM   68   C C   . PRO   A 1 9   ? -23.67346 -5.13983  2.61529   1.000 4.94325  ? 9   PRO   A C   1 
ATOM   69   O O   . PRO   A 1 9   ? -22.56923 -4.82079  3.04647   1.000 5.32344  ? 9   PRO   A O   1 
ATOM   70   C CB  . PRO   A 1 9   ? -25.33436 -4.93047  4.51856   1.000 14.23187 ? 9   PRO   A CB  1 
ATOM   71   C CG  . PRO   A 1 9   ? -25.32914 -5.68157  5.82252   1.000 11.81879 ? 9   PRO   A CG  1 
ATOM   72   C CD  . PRO   A 1 9   ? -24.12212 -6.58006  5.78486   1.000 5.62523  ? 9   PRO   A CD  1 
ATOM   73   N N   . SER   A 1 10  ? -24.06106 -4.91064  1.35751   1.000 6.27821  ? 10  SER   A N   1 
ATOM   74   C CA  . SER   A 1 10  ? -23.13238 -4.51034  0.30230   1.000 4.69688  ? 10  SER   A CA  1 
ATOM   75   C C   . SER   A 1 10  ? -23.15891 -3.01987  -0.01094  1.000 5.93538  ? 10  SER   A C   1 
ATOM   76   O O   . SER   A 1 10  ? -22.39010 -2.56732  -0.86233  1.000 3.99799  ? 10  SER   A O   1 
ATOM   77   C CB  . SER   A 1 10  ? -23.41456 -5.30154  -0.98126  1.000 5.72585  ? 10  SER   A CB  1 
ATOM   78   O OG  . SER   A 1 10  ? -24.69245 -4.99673  -1.52973  1.000 5.79657  ? 10  SER   A OG  1 
ATOM   79   N N   . GLY   A 1 11  ? -23.99129 -2.24660  0.67872   1.000 7.67258  ? 11  GLY   A N   1 
ATOM   80   C CA  . GLY   A 1 11  ? -24.16974 -0.84986  0.31282   1.000 6.62649  ? 11  GLY   A CA  1 
ATOM   81   C C   . GLY   A 1 11  ? -22.89178 -0.03662  0.35086   1.000 6.03606  ? 11  GLY   A C   1 
ATOM   82   O O   . GLY   A 1 11  ? -22.66091 0.80828   -0.51851  1.000 8.56697  ? 11  GLY   A O   1 
ATOM   83   N N   . LYS   A 1 12  ? -22.05968 -0.24728  1.37150   1.000 7.91787  ? 12  LYS   A N   1 
ATOM   84   C CA  . LYS   A 1 12  ? -20.80412 0.49467   1.44487   1.000 10.17571 ? 12  LYS   A CA  1 
ATOM   85   C C   . LYS   A 1 12  ? -19.92077 0.22450   0.23634   1.000 8.49384  ? 12  LYS   A C   1 
ATOM   86   O O   . LYS   A 1 12  ? -19.16219 1.10293   -0.19007  1.000 10.79290 ? 12  LYS   A O   1 
ATOM   87   C CB  . LYS   A 1 12  ? -20.05402 0.13989   2.72847   1.000 11.00432 ? 12  LYS   A CB  1 
ATOM   88   C CG  . LYS   A 1 12  ? -20.78617 0.56982   4.00445   1.000 14.25677 ? 12  LYS   A CG  1 
ATOM   89   C CD  . LYS   A 1 12  ? -19.82569 0.73192   5.16658   1.000 10.54666 ? 12  LYS   A CD  1 
ATOM   90   C CE  . LYS   A 1 12  ? -20.47888 0.32961   6.46934   1.000 25.49686 ? 12  LYS   A CE  1 
ATOM   91   N NZ  . LYS   A 1 12  ? -21.46668 1.37164   6.87205   1.000 20.39486 ? 12  LYS   A NZ  1 
ATOM   92   N N   . VAL   A 1 13  ? -19.97751 -0.98350  -0.31515  1.000 10.22698 ? 13  VAL   A N   1 
ATOM   93   C CA  . VAL   A 1 13  ? -19.15106 -1.26954  -1.48859  1.000 9.27751  ? 13  VAL   A CA  1 
ATOM   94   C C   . VAL   A 1 13  ? -19.84630 -0.77697  -2.74974  1.000 5.95039  ? 13  VAL   A C   1 
ATOM   95   O O   . VAL   A 1 13  ? -19.18797 -0.34523  -3.70761  1.000 6.24666  ? 13  VAL   A O   1 
ATOM   96   C CB  . VAL   A 1 13  ? -18.84364 -2.77756  -1.58356  1.000 3.58015  ? 13  VAL   A CB  1 
ATOM   97   C CG1 . VAL   A 1 13  ? -17.86398 -3.03889  -2.71973  1.000 4.79175  ? 13  VAL   A CG1 1 
ATOM   98   C CG2 . VAL   A 1 13  ? -18.36752 -3.33891  -0.24855  1.000 8.49967  ? 13  VAL   A CG2 1 
ATOM   99   N N   . GLU   A 1 14  ? -21.19107 -0.85990  -2.78023  1.000 4.55020  ? 14  GLU   A N   1 
ATOM   100  C CA  . GLU   A 1 14  ? -21.92176 -0.47703  -3.98555  1.000 9.79256  ? 14  GLU   A CA  1 
ATOM   101  C C   . GLU   A 1 14  ? -21.58311 0.94862   -4.38429  1.000 10.14696 ? 14  GLU   A C   1 
ATOM   102  O O   . GLU   A 1 14  ? -21.52259 1.25892   -5.57556  1.000 8.92311  ? 14  GLU   A O   1 
ATOM   103  C CB  . GLU   A 1 14  ? -23.44736 -0.61494  -3.79213  1.000 6.48445  ? 14  GLU   A CB  1 
ATOM   104  C CG  . GLU   A 1 14  ? -23.99444 -2.06512  -3.71306  1.000 6.45615  ? 14  GLU   A CG  1 
ATOM   105  C CD  . GLU   A 1 14  ? -25.44660 -2.10756  -3.21172  1.000 7.41814  ? 14  GLU   A CD  1 
ATOM   106  O OE1 . GLU   A 1 14  ? -26.26869 -1.34961  -3.74842  1.000 10.68979 ? 14  GLU   A OE1 1 
ATOM   107  O OE2 . GLU   A 1 14  ? -25.77173 -2.86568  -2.27462  1.000 10.76761 ? 14  GLU   A OE2 1 
ATOM   108  N N   . GLY   A 1 15  ? -21.36722 1.82602   -3.39825  1.000 7.45847  ? 15  GLY   A N   1 
ATOM   109  C CA  . GLY   A 1 15  ? -20.97869 3.20105   -3.66578  1.000 15.81282 ? 15  GLY   A CA  1 
ATOM   110  C C   . GLY   A 1 15  ? -19.57985 3.38216   -4.24820  1.000 14.46461 ? 15  GLY   A C   1 
ATOM   111  O O   . GLY   A 1 15  ? -19.20553 4.52018   -4.54759  1.000 16.06192 ? 15  GLY   A O   1 
ATOM   112  N N   . CYS   A 1 16  ? -18.80204 2.31461   -4.40815  1.000 12.85073 ? 16  CYS   A N   1 
ATOM   113  C CA  . CYS   A 1 16  ? -17.43584 2.41438   -4.92216  1.000 12.63539 ? 16  CYS   A CA  1 
ATOM   114  C C   . CYS   A 1 16  ? -17.24937 1.76747   -6.28358  1.000 13.21330 ? 16  CYS   A C   1 
ATOM   115  O O   . CYS   A 1 16  ? -16.14096 1.83870   -6.83905  1.000 12.71298 ? 16  CYS   A O   1 
ATOM   116  C CB  . CYS   A 1 16  ? -16.41213 1.79592   -3.94853  1.000 6.40007  ? 16  CYS   A CB  1 
ATOM   117  S SG  . CYS   A 1 16  ? -16.53088 2.23194   -2.18014  1.000 14.59568 ? 16  CYS   A SG  1 
ATOM   118  N N   . MET   A 1 17  ? -18.26985 1.12645   -6.84290  1.000 8.71821  ? 17  MET   A N   1 
ATOM   119  C CA  . MET   A 1 17  ? -18.07082 0.47346   -8.12776  1.000 12.36583 ? 17  MET   A CA  1 
ATOM   120  C C   . MET   A 1 17  ? -18.24926 1.44372   -9.29027  1.000 13.48647 ? 17  MET   A C   1 
ATOM   121  O O   . MET   A 1 17  ? -19.17523 2.26585   -9.31791  1.000 14.98746 ? 17  MET   A O   1 
ATOM   122  C CB  . MET   A 1 17  ? -18.98590 -0.73817  -8.27610  1.000 9.06622  ? 17  MET   A CB  1 
ATOM   123  C CG  . MET   A 1 17  ? -18.91196 -1.61634  -7.04834  1.000 12.14507 ? 17  MET   A CG  1 
ATOM   124  S SD  . MET   A 1 17  ? -17.21678 -2.21331  -6.74467  1.000 14.80903 ? 17  MET   A SD  1 
ATOM   125  C CE  . MET   A 1 17  ? -16.65253 -2.69705  -8.38964  1.000 15.27713 ? 17  MET   A CE  1 
ATOM   126  N N   . VAL   A 1 18  ? -17.33263 1.33993   -10.24774 1.000 14.84575 ? 18  VAL   A N   1 
ATOM   127  C CA  . VAL   A 1 18  ? -17.35686 2.09090   -11.48809 1.000 16.90295 ? 18  VAL   A CA  1 
ATOM   128  C C   . VAL   A 1 18  ? -17.04570 1.12672   -12.63519 1.000 14.61389 ? 18  VAL   A C   1 
ATOM   129  O O   . VAL   A 1 18  ? -16.77726 -0.05312  -12.42028 1.000 18.54294 ? 18  VAL   A O   1 
ATOM   130  C CB  . VAL   A 1 18  ? -16.36107 3.26558   -11.47000 1.000 15.69782 ? 18  VAL   A CB  1 
ATOM   131  C CG1 . VAL   A 1 18  ? -16.62691 4.14787   -10.26997 1.000 13.12017 ? 18  VAL   A CG1 1 
ATOM   132  C CG2 . VAL   A 1 18  ? -14.90899 2.76353   -11.48862 1.000 9.15843  ? 18  VAL   A CG2 1 
ATOM   133  N N   . GLN   A 1 19  ? -17.13269 1.62495   -13.85911 1.000 19.24159 ? 19  GLN   A N   1 
ATOM   134  C CA  . GLN   A 1 19  ? -16.68488 0.85479   -15.00561 1.000 19.09641 ? 19  GLN   A CA  1 
ATOM   135  C C   . GLN   A 1 19  ? -15.54582 1.60517   -15.66800 1.000 19.39994 ? 19  GLN   A C   1 
ATOM   136  O O   . GLN   A 1 19  ? -15.54246 2.83967   -15.73298 1.000 20.65021 ? 19  GLN   A O   1 
ATOM   137  C CB  . GLN   A 1 19  ? -17.80871 0.55561   -16.02146 1.000 21.39566 ? 19  GLN   A CB  1 
ATOM   138  C CG  . GLN   A 1 19  ? -18.47244 1.75126   -16.67380 1.000 32.72100 ? 19  GLN   A CG  1 
ATOM   139  C CD  . GLN   A 1 19  ? -19.16105 1.38499   -17.98094 1.000 27.57972 ? 19  GLN   A CD  1 
ATOM   140  O OE1 . GLN   A 1 19  ? -18.61992 0.63260   -18.78846 1.000 32.63767 ? 19  GLN   A OE1 1 
ATOM   141  N NE2 . GLN   A 1 19  ? -20.36627 1.91652   -18.19081 1.000 39.26203 ? 19  GLN   A NE2 1 
ATOM   142  N N   . VAL   A 1 20  ? -14.56190 0.83680   -16.10865 1.000 17.57591 ? 20  VAL   A N   1 
ATOM   143  C CA  . VAL   A 1 20  ? -13.36238 1.34249   -16.74052 1.000 14.34057 ? 20  VAL   A CA  1 
ATOM   144  C C   . VAL   A 1 20  ? -13.37382 0.82535   -18.16798 1.000 20.03330 ? 20  VAL   A C   1 
ATOM   145  O O   . VAL   A 1 20  ? -13.59704 -0.36959  -18.39951 1.000 17.95591 ? 20  VAL   A O   1 
ATOM   146  C CB  . VAL   A 1 20  ? -12.10147 0.87829   -15.98816 1.000 11.52796 ? 20  VAL   A CB  1 
ATOM   147  C CG1 . VAL   A 1 20  ? -10.85041 1.29855   -16.73927 1.000 12.39980 ? 20  VAL   A CG1 1 
ATOM   148  C CG2 . VAL   A 1 20  ? -12.10201 1.41415   -14.59246 1.000 9.37641  ? 20  VAL   A CG2 1 
ATOM   149  N N   . THR   A 1 21  ? -13.16923 1.71523   -19.12613 1.000 15.97525 ? 21  THR   A N   1 
ATOM   150  C CA  . THR   A 1 21  ? -13.06668 1.30606   -20.51586 1.000 20.53941 ? 21  THR   A CA  1 
ATOM   151  C C   . THR   A 1 21  ? -11.69191 1.70310   -21.03618 1.000 23.62232 ? 21  THR   A C   1 
ATOM   152  O O   . THR   A 1 21  ? -11.24929 2.84212   -20.84116 1.000 19.48714 ? 21  THR   A O   1 
ATOM   153  C CB  . THR   A 1 21  ? -14.19633 1.91042   -21.37163 1.000 23.67178 ? 21  THR   A CB  1 
ATOM   154  O OG1 . THR   A 1 21  ? -15.46400 1.42792   -20.90908 1.000 20.24529 ? 21  THR   A OG1 1 
ATOM   155  C CG2 . THR   A 1 21  ? -14.03305 1.51962   -22.85963 1.000 24.31881 ? 21  THR   A CG2 1 
ATOM   156  N N   . CYS   A 1 22  ? -11.01199 0.74426   -21.66283 1.000 23.14646 ? 22  CYS   A N   1 
ATOM   157  C CA  . CYS   A 1 22  ? -9.78382  0.98188   -22.40542 1.000 16.83100 ? 22  CYS   A CA  1 
ATOM   158  C C   . CYS   A 1 22  ? -9.83399  0.17353   -23.69397 1.000 23.74545 ? 22  CYS   A C   1 
ATOM   159  O O   . CYS   A 1 22  ? -9.98729  -1.05003  -23.64829 1.000 18.69065 ? 22  CYS   A O   1 
ATOM   160  C CB  . CYS   A 1 22  ? -8.56144  0.59505   -21.58281 1.000 18.02971 ? 22  CYS   A CB  1 
ATOM   161  S SG  . CYS   A 1 22  ? -7.00121  1.12657   -22.31938 1.000 34.16947 ? 22  CYS   A SG  1 
ATOM   162  N N   . GLY   A 1 23  ? -9.70485  0.85079   -24.83668 1.000 26.33270 ? 23  GLY   A N   1 
ATOM   163  C CA  . GLY   A 1 23  ? -9.81447  0.16844   -26.12434 1.000 26.29477 ? 23  GLY   A CA  1 
ATOM   164  C C   . GLY   A 1 23  ? -11.20384 -0.41507  -26.34068 1.000 25.79376 ? 23  GLY   A C   1 
ATOM   165  O O   . GLY   A 1 23  ? -12.20681 0.29911   -26.31903 1.000 27.36765 ? 23  GLY   A O   1 
ATOM   166  N N   . THR   A 1 24  ? -11.27536 -1.72978  -26.56389 1.000 32.40262 ? 24  THR   A N   1 
ATOM   167  C CA  . THR   A 1 24  ? -12.53498 -2.45217  -26.71798 1.000 32.76474 ? 24  THR   A CA  1 
ATOM   168  C C   . THR   A 1 24  ? -12.93282 -3.25063  -25.48054 1.000 33.43345 ? 24  THR   A C   1 
ATOM   169  O O   . THR   A 1 24  ? -13.88718 -4.03678  -25.55407 1.000 38.77161 ? 24  THR   A O   1 
ATOM   170  C CB  . THR   A 1 24  ? -12.45713 -3.43552  -27.87678 1.000 37.84310 ? 24  THR   A CB  1 
ATOM   171  O OG1 . THR   A 1 24  ? -11.52945 -4.47615  -27.52478 1.000 25.04871 ? 24  THR   A OG1 1 
ATOM   172  C CG2 . THR   A 1 24  ? -12.02140 -2.74601  -29.15669 1.000 37.09725 ? 24  THR   A CG2 1 
ATOM   173  N N   . THR   A 1 25  ? -12.21513 -3.10922  -24.36814 1.000 25.21253 ? 25  THR   A N   1 
ATOM   174  C CA  . THR   A 1 25  ? -12.43206 -3.94672  -23.19362 1.000 26.72694 ? 25  THR   A CA  1 
ATOM   175  C C   . THR   A 1 25  ? -13.03106 -3.10905  -22.07070 1.000 33.22015 ? 25  THR   A C   1 
ATOM   176  O O   . THR   A 1 25  ? -12.50419 -2.03596  -21.73513 1.000 25.61013 ? 25  THR   A O   1 
ATOM   177  C CB  . THR   A 1 25  ? -11.12951 -4.60457  -22.73515 1.000 26.04663 ? 25  THR   A CB  1 
ATOM   178  O OG1 . THR   A 1 25  ? -10.69549 -5.53875  -23.72897 1.000 34.41133 ? 25  THR   A OG1 1 
ATOM   179  C CG2 . THR   A 1 25  ? -11.33809 -5.34011  -21.40867 1.000 24.49199 ? 25  THR   A CG2 1 
ATOM   180  N N   . THR   A 1 26  ? -14.13185 -3.60582  -21.49995 1.000 23.92865 ? 26  THR   A N   1 
ATOM   181  C CA  . THR   A 1 26  ? -14.88668 -2.92601  -20.45504 1.000 23.24574 ? 26  THR   A CA  1 
ATOM   182  C C   . THR   A 1 26  ? -14.90232 -3.82372  -19.22597 1.000 17.71662 ? 26  THR   A C   1 
ATOM   183  O O   . THR   A 1 26  ? -15.25226 -5.00143  -19.32372 1.000 23.36455 ? 26  THR   A O   1 
ATOM   184  C CB  . THR   A 1 26  ? -16.30745 -2.58136  -20.93944 1.000 19.83155 ? 26  THR   A CB  1 
ATOM   185  O OG1 . THR   A 1 26  ? -16.23929 -1.47358  -21.85617 1.000 15.86202 ? 26  THR   A OG1 1 
ATOM   186  C CG2 . THR   A 1 26  ? -17.21857 -2.22693  -19.77973 1.000 21.65483 ? 26  THR   A CG2 1 
ATOM   187  N N   . LEU   A 1 27  ? -14.44365 -3.29287  -18.09503 1.000 17.35626 ? 27  LEU   A N   1 
ATOM   188  C CA  . LEU   A 1 27  ? -14.46379 -4.01980  -16.82991 1.000 20.87301 ? 27  LEU   A CA  1 
ATOM   189  C C   . LEU   A 1 27  ? -14.81206 -3.06344  -15.69687 1.000 16.27841 ? 27  LEU   A C   1 
ATOM   190  O O   . LEU   A 1 27  ? -15.03957 -1.87088  -15.91597 1.000 19.68302 ? 27  LEU   A O   1 
ATOM   191  C CB  . LEU   A 1 27  ? -13.13526 -4.75108  -16.56171 1.000 25.89091 ? 27  LEU   A CB  1 
ATOM   192  C CG  . LEU   A 1 27  ? -11.77499 -4.03852  -16.54023 1.000 14.54807 ? 27  LEU   A CG  1 
ATOM   193  C CD1 . LEU   A 1 27  ? -11.48156 -3.27096  -15.26549 1.000 17.10811 ? 27  LEU   A CD1 1 
ATOM   194  C CD2 . LEU   A 1 27  ? -10.72399 -5.10899  -16.69947 1.000 16.70608 ? 27  LEU   A CD2 1 
ATOM   195  N N   . ASN   A 1 28  ? -14.84764 -3.60793  -14.47280 1.000 14.42492 ? 28  ASN   A N   1 
ATOM   196  C CA  . ASN   A 1 28  ? -15.21451 -2.89610  -13.25088 1.000 14.99493 ? 28  ASN   A CA  1 
ATOM   197  C C   . ASN   A 1 28  ? -13.99225 -2.36523  -12.49973 1.000 11.42372 ? 28  ASN   A C   1 
ATOM   198  O O   . ASN   A 1 28  ? -12.89740 -2.92468  -12.57115 1.000 12.38055 ? 28  ASN   A O   1 
ATOM   199  C CB  . ASN   A 1 28  ? -16.01979 -3.81842  -12.31637 1.000 17.35720 ? 28  ASN   A CB  1 
ATOM   200  C CG  . ASN   A 1 28  ? -17.27656 -4.37646  -12.98389 1.000 21.08455 ? 28  ASN   A CG  1 
ATOM   201  O OD1 . ASN   A 1 28  ? -18.28480 -3.67134  -13.09891 1.000 23.32421 ? 28  ASN   A OD1 1 
ATOM   202  N ND2 . ASN   A 1 28  ? -17.21542 -5.63674  -13.44798 1.000 12.78265 ? 28  ASN   A ND2 1 
ATOM   203  N N   . GLY   A 1 29  ? -14.19757 -1.28843  -11.74415 1.000 9.43171  ? 29  GLY   A N   1 
ATOM   204  C CA  . GLY   A 1 29  ? -13.12404 -0.70236  -10.96765 1.000 9.33909  ? 29  GLY   A CA  1 
ATOM   205  C C   . GLY   A 1 29  ? -13.61055 -0.27682  -9.59901  1.000 9.87028  ? 29  GLY   A C   1 
ATOM   206  O O   . GLY   A 1 29  ? -14.80951 -0.10389  -9.35781  1.000 9.10996  ? 29  GLY   A O   1 
ATOM   207  N N   . LEU   A 1 30  ? -12.66126 -0.09166  -8.68991  1.000 7.53125  ? 30  LEU   A N   1 
ATOM   208  C CA  . LEU   A 1 30  ? -12.98645 0.24620   -7.31085  1.000 14.14522 ? 30  LEU   A CA  1 
ATOM   209  C C   . LEU   A 1 30  ? -12.51542 1.66952   -7.01530  1.000 11.34902 ? 30  LEU   A C   1 
ATOM   210  O O   . LEU   A 1 30  ? -11.31402 1.95106   -7.07526  1.000 8.75991  ? 30  LEU   A O   1 
ATOM   211  C CB  . LEU   A 1 30  ? -12.35533 -0.75723  -6.35027  1.000 5.14282  ? 30  LEU   A CB  1 
ATOM   212  C CG  . LEU   A 1 30  ? -12.92413 -0.72743  -4.93464  1.000 16.65876 ? 30  LEU   A CG  1 
ATOM   213  C CD1 . LEU   A 1 30  ? -14.16820 -1.60385  -4.83128  1.000 10.34849 ? 30  LEU   A CD1 1 
ATOM   214  C CD2 . LEU   A 1 30  ? -11.86702 -1.12921  -3.89756  1.000 13.58418 ? 30  LEU   A CD2 1 
ATOM   215  N N   . TRP   A 1 31  ? -13.45731 2.55302   -6.67134  1.000 9.37244  ? 31  TRP   A N   1 
ATOM   216  C CA  . TRP   A 1 31  ? -13.18969 3.98603   -6.53869  1.000 9.96289  ? 31  TRP   A CA  1 
ATOM   217  C C   . TRP   A 1 31  ? -13.20440 4.37572   -5.05784  1.000 12.04862 ? 31  TRP   A C   1 
ATOM   218  O O   . TRP   A 1 31  ? -14.26204 4.46887   -4.42266  1.000 9.20662  ? 31  TRP   A O   1 
ATOM   219  C CB  . TRP   A 1 31  ? -14.18753 4.78857   -7.37511  1.000 10.58409 ? 31  TRP   A CB  1 
ATOM   220  C CG  . TRP   A 1 31  ? -13.98441 6.27123   -7.33332  1.000 17.94308 ? 31  TRP   A CG  1 
ATOM   221  C CD1 . TRP   A 1 31  ? -12.80855 6.94786   -7.06591  1.000 12.31032 ? 31  TRP   A CD1 1 
ATOM   222  C CD2 . TRP   A 1 31  ? -14.99177 7.28018   -7.53277  1.000 19.38741 ? 31  TRP   A CD2 1 
ATOM   223  N NE1 . TRP   A 1 31  ? -13.03453 8.30202   -7.11731  1.000 14.97550 ? 31  TRP   A NE1 1 
ATOM   224  C CE2 . TRP   A 1 31  ? -14.36009 8.53174   -7.40470  1.000 18.12402 ? 31  TRP   A CE2 1 
ATOM   225  C CE3 . TRP   A 1 31  ? -16.36083 7.24327   -7.83309  1.000 15.72698 ? 31  TRP   A CE3 1 
ATOM   226  C CZ2 . TRP   A 1 31  ? -15.05829 9.73396   -7.54283  1.000 18.16933 ? 31  TRP   A CZ2 1 
ATOM   227  C CZ3 . TRP   A 1 31  ? -17.04408 8.43263   -7.96502  1.000 20.62498 ? 31  TRP   A CZ3 1 
ATOM   228  C CH2 . TRP   A 1 31  ? -16.39311 9.66157   -7.82071  1.000 20.08552 ? 31  TRP   A CH2 1 
ATOM   229  N N   . LEU   A 1 32  ? -12.00562 4.57176   -4.50887  1.000 12.94761 ? 32  LEU   A N   1 
ATOM   230  C CA  . LEU   A 1 32  ? -11.80414 5.06595   -3.15441  1.000 12.78584 ? 32  LEU   A CA  1 
ATOM   231  C C   . LEU   A 1 32  ? -10.96596 6.33679   -3.22761  1.000 19.92666 ? 32  LEU   A C   1 
ATOM   232  O O   . LEU   A 1 32  ? -9.93394  6.37685   -3.92195  1.000 10.62586 ? 32  LEU   A O   1 
ATOM   233  C CB  . LEU   A 1 32  ? -11.11787 4.01782   -2.28096  1.000 13.71497 ? 32  LEU   A CB  1 
ATOM   234  C CG  . LEU   A 1 32  ? -11.78702 2.64411   -2.25063  1.000 12.09138 ? 32  LEU   A CG  1 
ATOM   235  C CD1 . LEU   A 1 32  ? -10.82394 1.58600   -1.73290  1.000 8.68954  ? 32  LEU   A CD1 1 
ATOM   236  C CD2 . LEU   A 1 32  ? -13.03903 2.71889   -1.37737  1.000 12.80408 ? 32  LEU   A CD2 1 
ATOM   237  N N   . ASP   A 1 33  ? -11.42758 7.37634   -2.53794  1.000 12.86507 ? 33  ASP   A N   1 
ATOM   238  C CA  . ASP   A 1 33  ? -10.73275 8.65547   -2.52708  1.000 17.11162 ? 33  ASP   A CA  1 
ATOM   239  C C   . ASP   A 1 33  ? -10.63069 9.07775   -3.98278  1.000 20.11478 ? 33  ASP   A C   1 
ATOM   240  O O   . ASP   A 1 33  ? -11.65884 9.01816   -4.69076  1.000 18.60374 ? 33  ASP   A O   1 
ATOM   241  C CB  . ASP   A 1 33  ? -9.41772  8.50150   -1.77115  1.000 14.81214 ? 33  ASP   A CB  1 
ATOM   242  C CG  . ASP   A 1 33  ? -9.61206  7.86634   -0.40499  1.000 27.76005 ? 33  ASP   A CG  1 
ATOM   243  O OD1 . ASP   A 1 33  ? -10.53985 8.31625   0.31177   1.000 21.02297 ? 33  ASP   A OD1 1 
ATOM   244  O OD2 . ASP   A 1 33  ? -8.84132  6.93337   -0.05124  1.000 21.15103 ? 33  ASP   A OD2 1 
ATOM   245  N N   . ASP   A 1 34  ? -9.45626  9.45567   -4.49556  1.000 16.96383 ? 34  ASP   A N   1 
ATOM   246  C CA  . ASP   A 1 34  ? -9.31976  9.90058   -5.87646  1.000 15.58848 ? 34  ASP   A CA  1 
ATOM   247  C C   . ASP   A 1 34  ? -8.66918  8.85374   -6.77540  1.000 16.40901 ? 34  ASP   A C   1 
ATOM   248  O O   . ASP   A 1 34  ? -8.08262  9.20164   -7.80515  1.000 16.69160 ? 34  ASP   A O   1 
ATOM   249  C CB  . ASP   A 1 34  ? -8.54506  11.22011  -5.95868  1.000 17.48262 ? 34  ASP   A CB  1 
ATOM   250  C CG  . ASP   A 1 34  ? -7.27876  11.23428  -5.09756  1.000 20.25326 ? 34  ASP   A CG  1 
ATOM   251  O OD1 . ASP   A 1 34  ? -7.09900  10.34674  -4.23595  1.000 26.18811 ? 34  ASP   A OD1 1 
ATOM   252  O OD2 . ASP   A 1 34  ? -6.45407  12.15089  -5.28921  1.000 22.57031 ? 34  ASP   A OD2 1 
ATOM   253  N N   . VAL   A 1 35  ? -8.80111  7.56960   -6.45010  1.000 20.10225 ? 35  VAL   A N   1 
ATOM   254  C CA  . VAL   A 1 35  ? -8.11140  6.51515   -7.19031  1.000 14.39328 ? 35  VAL   A CA  1 
ATOM   255  C C   . VAL   A 1 35  ? -9.10284  5.41927   -7.56869  1.000 12.84362 ? 35  VAL   A C   1 
ATOM   256  O O   . VAL   A 1 35  ? -9.97182  5.05504   -6.76894  1.000 7.87061  ? 35  VAL   A O   1 
ATOM   257  C CB  . VAL   A 1 35  ? -6.93673  5.93576   -6.36707  1.000 13.78895 ? 35  VAL   A CB  1 
ATOM   258  C CG1 . VAL   A 1 35  ? -6.36363  4.69718   -7.05549  1.000 16.06671 ? 35  VAL   A CG1 1 
ATOM   259  C CG2 . VAL   A 1 35  ? -5.86491  6.97085   -6.17540  1.000 12.03570 ? 35  VAL   A CG2 1 
ATOM   260  N N   . VAL   A 1 36  ? -8.97906  4.89907   -8.79219  1.000 7.80539  ? 36  VAL   A N   1 
ATOM   261  C CA  . VAL   A 1 36  ? -9.77422  3.76521   -9.25345  1.000 11.17253 ? 36  VAL   A CA  1 
ATOM   262  C C   . VAL   A 1 36  ? -8.82367  2.59309   -9.45655  1.000 14.65158 ? 36  VAL   A C   1 
ATOM   263  O O   . VAL   A 1 36  ? -7.84370  2.70435   -10.20792 1.000 14.11192 ? 36  VAL   A O   1 
ATOM   264  C CB  . VAL   A 1 36  ? -10.53893 4.05910   -10.56023 1.000 11.39618 ? 36  VAL   A CB  1 
ATOM   265  C CG1 . VAL   A 1 36  ? -11.09701 2.74902   -11.15742 1.000 13.70973 ? 36  VAL   A CG1 1 
ATOM   266  C CG2 . VAL   A 1 36  ? -11.65454 5.05817   -10.35972 1.000 13.96727 ? 36  VAL   A CG2 1 
ATOM   267  N N   . TYR   A 1 37  ? -9.11378  1.47477   -8.79843  1.000 9.47896  ? 37  TYR   A N   1 
ATOM   268  C CA  . TYR   A 1 37  ? -8.31587  0.26008   -8.92582  1.000 12.39066 ? 37  TYR   A CA  1 
ATOM   269  C C   . TYR   A 1 37  ? -9.02922  -0.72691  -9.83500  1.000 9.96750  ? 37  TYR   A C   1 
ATOM   270  O O   . TYR   A 1 37  ? -10.25694 -0.86612  -9.76728  1.000 9.80430  ? 37  TYR   A O   1 
ATOM   271  C CB  . TYR   A 1 37  ? -8.07451  -0.40238  -7.57255  1.000 10.23998 ? 37  TYR   A CB  1 
ATOM   272  C CG  . TYR   A 1 37  ? -7.49568  0.49129   -6.52276  1.000 7.15003  ? 37  TYR   A CG  1 
ATOM   273  C CD1 . TYR   A 1 37  ? -8.30628  1.34050   -5.78283  1.000 9.50058  ? 37  TYR   A CD1 1 
ATOM   274  C CD2 . TYR   A 1 37  ? -6.13703  0.49537   -6.27260  1.000 6.57897  ? 37  TYR   A CD2 1 
ATOM   275  C CE1 . TYR   A 1 37  ? -7.78138  2.14961   -4.84093  1.000 6.57718  ? 37  TYR   A CE1 1 
ATOM   276  C CE2 . TYR   A 1 37  ? -5.60530  1.30133   -5.31776  1.000 7.27827  ? 37  TYR   A CE2 1 
ATOM   277  C CZ  . TYR   A 1 37  ? -6.42711  2.12276   -4.60245  1.000 5.62895  ? 37  TYR   A CZ  1 
ATOM   278  O OH  . TYR   A 1 37  ? -5.89483  2.94347   -3.64020  1.000 8.07263  ? 37  TYR   A OH  1 
ATOM   279  N N   . CYS   A 1 38  ? -8.25967  -1.42270  -10.67072 1.000 7.92227  ? 38  CYS   A N   1 
ATOM   280  C CA  . CYS   A 1 38  ? -8.84385  -2.39127  -11.58502 1.000 8.32991  ? 38  CYS   A CA  1 
ATOM   281  C C   . CYS   A 1 38  ? -7.73763  -3.32746  -12.08028 1.000 10.60169 ? 38  CYS   A C   1 
ATOM   282  O O   . CYS   A 1 38  ? -6.55322  -3.00497  -11.97941 1.000 9.48761  ? 38  CYS   A O   1 
ATOM   283  C CB  . CYS   A 1 38  ? -9.54829  -1.68332  -12.75269 1.000 9.12052  ? 38  CYS   A CB  1 
ATOM   284  S SG  . CYS   A 1 38  ? -8.42839  -0.87946  -13.93024 1.000 21.89562 ? 38  CYS   A SG  1 
ATOM   285  N N   . PRO   A 1 39  ? -8.09348  -4.50550  -12.59101 1.000 12.85817 ? 39  PRO   A N   1 
ATOM   286  C CA  . PRO   A 1 39  ? -7.06138  -5.40411  -13.12254 1.000 10.94315 ? 39  PRO   A CA  1 
ATOM   287  C C   . PRO   A 1 39  ? -6.26337  -4.75064  -14.24146 1.000 10.78730 ? 39  PRO   A C   1 
ATOM   288  O O   . PRO   A 1 39  ? -6.80421  -4.04680  -15.10036 1.000 12.04324 ? 39  PRO   A O   1 
ATOM   289  C CB  . PRO   A 1 39  ? -7.86449  -6.61264  -13.61466 1.000 13.32909 ? 39  PRO   A CB  1 
ATOM   290  C CG  . PRO   A 1 39  ? -9.11445  -6.58615  -12.77022 1.000 12.48424 ? 39  PRO   A CG  1 
ATOM   291  C CD  . PRO   A 1 39  ? -9.42689  -5.13547  -12.59610 1.000 14.40744 ? 39  PRO   A CD  1 
ATOM   292  N N   . ARG   A 1 40  ? -4.94922  -4.97418  -14.20899 1.000 9.88552  ? 40  ARG   A N   1 
ATOM   293  C CA  . ARG   A 1 40  ? -4.09153  -4.34324  -15.19564 1.000 13.49446 ? 40  ARG   A CA  1 
ATOM   294  C C   . ARG   A 1 40  ? -4.30708  -4.92036  -16.58998 1.000 16.15201 ? 40  ARG   A C   1 
ATOM   295  O O   . ARG   A 1 40  ? -3.93529  -4.27407  -17.57060 1.000 18.72704 ? 40  ARG   A O   1 
ATOM   296  C CB  . ARG   A 1 40  ? -2.62127  -4.45908  -14.76349 1.000 12.59942 ? 40  ARG   A CB  1 
ATOM   297  C CG  . ARG   A 1 40  ? -2.02034  -5.85247  -14.84083 1.000 14.62967 ? 40  ARG   A CG  1 
ATOM   298  C CD  . ARG   A 1 40  ? -0.53097  -5.83987  -14.54496 1.000 9.98508  ? 40  ARG   A CD  1 
ATOM   299  N NE  . ARG   A 1 40  ? 0.07284   -7.17274  -14.63546 1.000 13.81445 ? 40  ARG   A NE  1 
ATOM   300  C CZ  . ARG   A 1 40  ? 1.37938   -7.42005  -14.49569 1.000 16.92648 ? 40  ARG   A CZ  1 
ATOM   301  N NH1 . ARG   A 1 40  ? 2.24153   -6.42817  -14.27133 1.000 9.92582  ? 40  ARG   A NH1 1 
ATOM   302  N NH2 . ARG   A 1 40  ? 1.83429   -8.65931  -14.61073 1.000 8.70282  ? 40  ARG   A NH2 1 
ATOM   303  N N   . HIS   A 1 41  ? -4.93295  -6.09710  -16.70670 1.000 15.69453 ? 41  HIS   A N   1 
ATOM   304  C CA  . HIS   A 1 41  ? -5.14747  -6.66208  -18.04181 1.000 22.18746 ? 41  HIS   A CA  1 
ATOM   305  C C   . HIS   A 1 41  ? -6.20166  -5.90120  -18.85924 1.000 14.61753 ? 41  HIS   A C   1 
ATOM   306  O O   . HIS   A 1 41  ? -6.42647  -6.25384  -20.01981 1.000 17.24169 ? 41  HIS   A O   1 
ATOM   307  C CB  . HIS   A 1 41  ? -5.49461  -8.16378  -17.95168 1.000 17.32016 ? 41  HIS   A CB  1 
ATOM   308  C CG  . HIS   A 1 41  ? -6.87337  -8.46319  -17.43774 1.000 15.35699 ? 41  HIS   A CG  1 
ATOM   309  N ND1 . HIS   A 1 41  ? -8.01992  -8.14536  -18.13519 1.000 26.10363 ? 41  HIS   A ND1 1 
ATOM   310  C CD2 . HIS   A 1 41  ? -7.28494  -9.09875  -16.31412 1.000 16.87161 ? 41  HIS   A CD2 1 
ATOM   311  C CE1 . HIS   A 1 41  ? -9.07771  -8.54350  -17.44961 1.000 26.84386 ? 41  HIS   A CE1 1 
ATOM   312  N NE2 . HIS   A 1 41  ? -8.65819  -9.13010  -16.34330 1.000 14.89999 ? 41  HIS   A NE2 1 
ATOM   313  N N   . VAL   A 1 42  ? -6.82016  -4.85766  -18.30550 1.000 14.05409 ? 42  VAL   A N   1 
ATOM   314  C CA  . VAL   A 1 42  ? -7.71150  -4.00240  -19.08932 1.000 17.47569 ? 42  VAL   A CA  1 
ATOM   315  C C   . VAL   A 1 42  ? -6.98976  -3.30019  -20.23717 1.000 17.04270 ? 42  VAL   A C   1 
ATOM   316  O O   . VAL   A 1 42  ? -7.62439  -2.94132  -21.24301 1.000 15.35188 ? 42  VAL   A O   1 
ATOM   317  C CB  . VAL   A 1 42  ? -8.39863  -2.96864  -18.16305 1.000 21.37701 ? 42  VAL   A CB  1 
ATOM   318  C CG1 . VAL   A 1 42  ? -7.40175  -1.93348  -17.64614 1.000 19.26799 ? 42  VAL   A CG1 1 
ATOM   319  C CG2 . VAL   A 1 42  ? -9.54912  -2.30603  -18.86590 1.000 22.48270 ? 42  VAL   A CG2 1 
ATOM   320  N N   . ILE   A 1 43  ? -5.67721  -3.07318  -20.11720 1.000 18.94801 ? 43  ILE   A N   1 
ATOM   321  C CA  . ILE   A 1 43  ? -4.95749  -2.39176  -21.19542 1.000 19.03491 ? 43  ILE   A CA  1 
ATOM   322  C C   . ILE   A 1 43  ? -4.60925  -3.33003  -22.33850 1.000 20.86524 ? 43  ILE   A C   1 
ATOM   323  O O   . ILE   A 1 43  ? -4.14310  -2.87419  -23.38827 1.000 23.66436 ? 43  ILE   A O   1 
ATOM   324  C CB  . ILE   A 1 43  ? -3.67721  -1.70794  -20.68102 1.000 19.40489 ? 43  ILE   A CB  1 
ATOM   325  C CG1 . ILE   A 1 43  ? -2.55699  -2.72102  -20.44218 1.000 18.55078 ? 43  ILE   A CG1 1 
ATOM   326  C CG2 . ILE   A 1 43  ? -3.95507  -0.91493  -19.40544 1.000 20.28451 ? 43  ILE   A CG2 1 
ATOM   327  C CD1 . ILE   A 1 43  ? -1.24336  -2.05525  -20.00698 1.000 16.71438 ? 43  ILE   A CD1 1 
ATOM   328  N N   . CYS   A 1 44  ? -4.87734  -4.61775  -22.18493 1.000 20.22787 ? 44  CYS   A N   1 
ATOM   329  C CA  . CYS   A 1 44  ? -4.46803  -5.62657  -23.14766 1.000 21.60211 ? 44  CYS   A CA  1 
ATOM   330  C C   . CYS   A 1 44  ? -5.51004  -5.87743  -24.22873 1.000 32.08794 ? 44  CYS   A C   1 
ATOM   331  O O   . CYS   A 1 44  ? -6.71654  -5.93790  -23.96100 1.000 32.49468 ? 44  CYS   A O   1 
ATOM   332  C CB  . CYS   A 1 44  ? -4.17086  -6.93172  -22.42493 1.000 24.80449 ? 44  CYS   A CB  1 
ATOM   333  S SG  . CYS   A 1 44  ? -2.78990  -6.77859  -21.26231 1.000 28.21134 ? 44  CYS   A SG  1 
ATOM   334  N N   . THR   A 1 45  ? -5.02277  -6.03467  -25.45684 1.000 36.44216 ? 45  THR   A N   1 
ATOM   335  C CA  . THR   A 1 45  ? -5.83227  -6.54129  -26.54847 1.000 40.09083 ? 45  THR   A CA  1 
ATOM   336  C C   . THR   A 1 45  ? -5.99874  -8.04914  -26.39227 1.000 45.37058 ? 45  THR   A C   1 
ATOM   337  O O   . THR   A 1 45  ? -5.52819  -8.66231  -25.42836 1.000 44.46231 ? 45  THR   A O   1 
ATOM   338  C CB  . THR   A 1 45  ? -5.19038  -6.21691  -27.89616 1.000 30.24816 ? 45  THR   A CB  1 
ATOM   339  O OG1 . THR   A 1 45  ? -4.11647  -7.12889  -28.13467 1.000 34.38257 ? 45  THR   A OG1 1 
ATOM   340  C CG2 . THR   A 1 45  ? -4.65614  -4.78849  -27.90966 1.000 30.15999 ? 45  THR   A CG2 1 
ATOM   341  N N   . SER   A 1 46  ? -6.66682  -8.66060  -27.36941 1.000 48.81922 ? 46  SER   A N   1 
ATOM   342  C CA  . SER   A 1 46  ? -6.81648  -10.11087 -27.36418 1.000 47.50203 ? 46  SER   A CA  1 
ATOM   343  C C   . SER   A 1 46  ? -5.47177  -10.81362 -27.55426 1.000 53.90032 ? 46  SER   A C   1 
ATOM   344  O O   . SER   A 1 46  ? -5.16518  -11.78844 -26.85093 1.000 46.50782 ? 46  SER   A O   1 
ATOM   345  C CB  . SER   A 1 46  ? -7.81569  -10.51685 -28.44486 1.000 50.07790 ? 46  SER   A CB  1 
ATOM   346  O OG  . SER   A 1 46  ? -7.59951  -9.74817  -29.61407 1.000 54.84313 ? 46  SER   A OG  1 
ATOM   347  N N   . GLU   A 1 47  ? -4.64892  -10.32681 -28.48857 1.000 49.04290 ? 47  GLU   A N   1 
ATOM   348  C CA  . GLU   A 1 47  ? -3.36479  -10.95383 -28.77446 1.000 49.48031 ? 47  GLU   A CA  1 
ATOM   349  C C   . GLU   A 1 47  ? -2.25959  -10.42157 -27.88101 1.000 42.54784 ? 47  GLU   A C   1 
ATOM   350  O O   . GLU   A 1 47  ? -1.15074  -10.97323 -27.88364 1.000 40.71873 ? 47  GLU   A O   1 
ATOM   351  C CB  . GLU   A 1 47  ? -3.00433  -10.75223 -30.24686 1.000 49.50557 ? 47  GLU   A CB  1 
ATOM   352  C CG  . GLU   A 1 47  ? -4.15806  -11.11239 -31.16748 1.000 48.91660 ? 47  GLU   A CG  1 
ATOM   353  C CD  . GLU   A 1 47  ? -4.94971  -9.88644  -31.60139 1.000 56.28704 ? 47  GLU   A CD  1 
ATOM   354  O OE1 . GLU   A 1 47  ? -4.37788  -8.77674  -31.57522 1.000 59.94970 ? 47  GLU   A OE1 1 
ATOM   355  O OE2 . GLU   A 1 47  ? -6.14407  -10.02713 -31.92291 1.000 58.72686 ? 47  GLU   A OE2 1 
ATOM   356  N N   . ASP   A 1 48  ? -2.54929  -9.36407  -27.12043 1.000 41.83530 ? 48  ASP   A N   1 
ATOM   357  C CA  . ASP   A 1 48  ? -1.68145  -8.98746  -26.01557 1.000 41.87328 ? 48  ASP   A CA  1 
ATOM   358  C C   . ASP   A 1 48  ? -1.75362  -10.01038 -24.87343 1.000 42.34071 ? 48  ASP   A C   1 
ATOM   359  O O   . ASP   A 1 48  ? -0.71290  -10.39157 -24.32572 1.000 38.18650 ? 48  ASP   A O   1 
ATOM   360  C CB  . ASP   A 1 48  ? -2.02901  -7.56641  -25.54008 1.000 37.10091 ? 48  ASP   A CB  1 
ATOM   361  C CG  . ASP   A 1 48  ? -1.37245  -6.46895  -26.41625 1.000 37.10505 ? 48  ASP   A CG  1 
ATOM   362  O OD1 . ASP   A 1 48  ? -0.35639  -6.74066  -27.12764 1.000 36.53695 ? 48  ASP   A OD1 1 
ATOM   363  O OD2 . ASP   A 1 48  ? -1.89708  -5.33804  -26.41686 1.000 29.38924 ? 48  ASP   A OD2 1 
ATOM   364  N N   . MET   A 1 49  ? -2.96819  -10.49261 -24.49966 1.000 48.77486 ? 49  MET   A N   1 
ATOM   365  C CA  . MET   A 1 49  ? -3.15816  -11.51976 -23.43766 1.000 43.57837 ? 49  MET   A CA  1 
ATOM   366  C C   . MET   A 1 49  ? -2.36643  -12.76346 -23.64700 1.000 50.13363 ? 49  MET   A C   1 
ATOM   367  O O   . MET   A 1 49  ? -2.60224  -13.71737 -22.89380 1.000 51.44507 ? 49  MET   A O   1 
ATOM   368  C CB  . MET   A 1 49  ? -4.63002  -11.90873 -23.28941 1.000 46.15730 ? 49  MET   A CB  1 
ATOM   369  C CG  . MET   A 1 49  ? -5.49727  -10.86184 -22.65405 1.000 55.53196 ? 49  MET   A CG  1 
ATOM   370  S SD  . MET   A 1 49  ? -4.95808  -10.46883 -20.98131 1.000 71.42651 ? 49  MET   A SD  1 
ATOM   371  C CE  . MET   A 1 49  ? -5.28284  -12.00476 -20.05767 1.000 46.05498 ? 49  MET   A CE  1 
ATOM   372  N N   . LEU   A 1 50  ? -1.46118  -12.87287 -24.61157 1.000 44.63381 ? 50  LEU   A N   1 
ATOM   373  C CA  . LEU   A 1 50  ? -0.67463  -14.08684 -24.72729 1.000 44.18044 ? 50  LEU   A CA  1 
ATOM   374  C C   . LEU   A 1 50  ? 0.61426   -13.91642 -23.93859 1.000 46.81897 ? 50  LEU   A C   1 
ATOM   375  O O   . LEU   A 1 50  ? 0.71456   -14.37904 -22.79670 1.000 52.01913 ? 50  LEU   A O   1 
ATOM   376  C CB  . LEU   A 1 50  ? -0.41907  -14.40165 -26.19794 1.000 49.10739 ? 50  LEU   A CB  1 
ATOM   377  C CG  . LEU   A 1 50  ? -1.71297  -14.81317 -26.91347 1.000 52.39187 ? 50  LEU   A CG  1 
ATOM   378  C CD1 . LEU   A 1 50  ? -1.64906  -14.54768 -28.42094 1.000 45.16390 ? 50  LEU   A CD1 1 
ATOM   379  C CD2 . LEU   A 1 50  ? -2.05904  -16.27715 -26.62251 1.000 37.70338 ? 50  LEU   A CD2 1 
ATOM   380  N N   . ASN   A 1 51  ? 1.59820   -13.25539 -24.52840 1.000 40.98279 ? 51  ASN   A N   1 
ATOM   381  C CA  . ASN   A 1 51  ? 2.81271   -12.93656 -23.79601 1.000 36.33154 ? 51  ASN   A CA  1 
ATOM   382  C C   . ASN   A 1 51  ? 2.96380   -11.42716 -23.65933 1.000 40.45750 ? 51  ASN   A C   1 
ATOM   383  O O   . ASN   A 1 51  ? 3.64456   -10.79716 -24.47856 1.000 47.54721 ? 51  ASN   A O   1 
ATOM   384  C CB  . ASN   A 1 51  ? 4.03940   -13.53261 -24.48664 1.000 42.72441 ? 51  ASN   A CB  1 
ATOM   385  C CG  . ASN   A 1 51  ? 5.08819   -14.00487 -23.49592 1.000 34.46267 ? 51  ASN   A CG  1 
ATOM   386  O OD1 . ASN   A 1 51  ? 4.98111   -13.74990 -22.29662 1.000 39.55993 ? 51  ASN   A OD1 1 
ATOM   387  N ND2 . ASN   A 1 51  ? 6.10394   -14.70112 -23.99061 1.000 36.26064 ? 51  ASN   A ND2 1 
ATOM   388  N N   . PRO   A 1 52  ? 2.35278   -10.81220 -22.64982 1.000 37.39558 ? 52  PRO   A N   1 
ATOM   389  C CA  . PRO   A 1 52  ? 2.44003   -9.35797  -22.50468 1.000 37.09499 ? 52  PRO   A CA  1 
ATOM   390  C C   . PRO   A 1 52  ? 3.59930   -8.88730  -21.63855 1.000 31.33612 ? 52  PRO   A C   1 
ATOM   391  O O   . PRO   A 1 52  ? 4.03170   -9.53048  -20.67924 1.000 22.44329 ? 52  PRO   A O   1 
ATOM   392  C CB  . PRO   A 1 52  ? 1.09591   -9.00136  -21.85503 1.000 32.80743 ? 52  PRO   A CB  1 
ATOM   393  C CG  . PRO   A 1 52  ? 0.74947   -10.20137 -21.05981 1.000 33.72394 ? 52  PRO   A CG  1 
ATOM   394  C CD  . PRO   A 1 52  ? 1.36077   -11.39752 -21.73373 1.000 36.81056 ? 52  PRO   A CD  1 
ATOM   395  N N   . ASN   A 1 53  ? 4.13277   -7.74989  -22.03406 1.000 25.34929 ? 53  ASN   A N   1 
ATOM   396  C CA  . ASN   A 1 53  ? 5.06155   -6.99124  -21.21566 1.000 25.40906 ? 53  ASN   A CA  1 
ATOM   397  C C   . ASN   A 1 53  ? 4.27685   -5.75273  -20.79279 1.000 29.27380 ? 53  ASN   A C   1 
ATOM   398  O O   . ASN   A 1 53  ? 4.07154   -4.83138  -21.59151 1.000 28.65512 ? 53  ASN   A O   1 
ATOM   399  C CB  . ASN   A 1 53  ? 6.33434   -6.67681  -21.99408 1.000 29.42603 ? 53  ASN   A CB  1 
ATOM   400  C CG  . ASN   A 1 53  ? 7.39948   -6.04575  -21.13402 1.000 29.01756 ? 53  ASN   A CG  1 
ATOM   401  O OD1 . ASN   A 1 53  ? 7.22058   -4.93348  -20.64941 1.000 27.02068 ? 53  ASN   A OD1 1 
ATOM   402  N ND2 . ASN   A 1 53  ? 8.51191   -6.75600  -20.92752 1.000 24.12078 ? 53  ASN   A ND2 1 
ATOM   403  N N   . TYR   A 1 54  ? 3.77081   -5.77193  -19.55468 1.000 27.78242 ? 54  TYR   A N   1 
ATOM   404  C CA  . TYR   A 1 54  ? 2.84636   -4.73118  -19.12610 1.000 25.67169 ? 54  TYR   A CA  1 
ATOM   405  C C   . TYR   A 1 54  ? 3.54964   -3.39530  -18.92390 1.000 26.19234 ? 54  TYR   A C   1 
ATOM   406  O O   . TYR   A 1 54  ? 2.93261   -2.34174  -19.11520 1.000 20.94761 ? 54  TYR   A O   1 
ATOM   407  C CB  . TYR   A 1 54  ? 2.13499   -5.13786  -17.83659 1.000 21.32534 ? 54  TYR   A CB  1 
ATOM   408  C CG  . TYR   A 1 54  ? 1.06662   -6.20448  -17.98135 1.000 16.52057 ? 54  TYR   A CG  1 
ATOM   409  C CD1 . TYR   A 1 54  ? 1.40247   -7.54638  -18.09076 1.000 18.31906 ? 54  TYR   A CD1 1 
ATOM   410  C CD2 . TYR   A 1 54  ? -0.27748  -5.86679  -17.95171 1.000 17.23009 ? 54  TYR   A CD2 1 
ATOM   411  C CE1 . TYR   A 1 54  ? 0.43147   -8.51295  -18.19432 1.000 19.24387 ? 54  TYR   A CE1 1 
ATOM   412  C CE2 . TYR   A 1 54  ? -1.25514  -6.82444  -18.05423 1.000 20.27764 ? 54  TYR   A CE2 1 
ATOM   413  C CZ  . TYR   A 1 54  ? -0.89464  -8.14418  -18.18193 1.000 17.59415 ? 54  TYR   A CZ  1 
ATOM   414  O OH  . TYR   A 1 54  ? -1.86853  -9.09537  -18.28210 1.000 19.33109 ? 54  TYR   A OH  1 
ATOM   415  N N   . GLU   A 1 55  ? 4.81358   -3.40815  -18.49666 1.000 24.31894 ? 55  GLU   A N   1 
ATOM   416  C CA  . GLU   A 1 55  ? 5.57139   -2.16428  -18.47426 1.000 26.70077 ? 55  GLU   A CA  1 
ATOM   417  C C   . GLU   A 1 55  ? 5.56059   -1.52016  -19.85328 1.000 26.34912 ? 55  GLU   A C   1 
ATOM   418  O O   . GLU   A 1 55  ? 5.30800   -0.31889  -19.98971 1.000 27.18493 ? 55  GLU   A O   1 
ATOM   419  C CB  . GLU   A 1 55  ? 7.00951   -2.41540  -18.00491 1.000 25.24656 ? 55  GLU   A CB  1 
ATOM   420  C CG  . GLU   A 1 55  ? 7.21084   -2.50394  -16.49559 1.000 25.47614 ? 55  GLU   A CG  1 
ATOM   421  C CD  . GLU   A 1 55  ? 6.73001   -3.81589  -15.90486 1.000 38.53007 ? 55  GLU   A CD  1 
ATOM   422  O OE1 . GLU   A 1 55  ? 6.69266   -4.84128  -16.62727 1.000 35.78145 ? 55  GLU   A OE1 1 
ATOM   423  O OE2 . GLU   A 1 55  ? 6.39465   -3.82770  -14.70148 1.000 48.01027 ? 55  GLU   A OE2 1 
ATOM   424  N N   . ASP   A 1 56  ? 5.78451   -2.33339  -20.88966 1.000 21.07086 ? 56  ASP   A N   1 
ATOM   425  C CA  . ASP   A 1 56  ? 5.81241   -1.85983  -22.27056 1.000 31.28993 ? 56  ASP   A CA  1 
ATOM   426  C C   . ASP   A 1 56  ? 4.44678   -1.37819  -22.74924 1.000 26.25285 ? 56  ASP   A C   1 
ATOM   427  O O   . ASP   A 1 56  ? 4.35777   -0.37367  -23.46879 1.000 21.02681 ? 56  ASP   A O   1 
ATOM   428  C CB  . ASP   A 1 56  ? 6.31111   -2.98224  -23.17585 1.000 33.45811 ? 56  ASP   A CB  1 
ATOM   429  C CG  . ASP   A 1 56  ? 7.80395   -2.97816  -23.33027 1.000 25.39388 ? 56  ASP   A CG  1 
ATOM   430  O OD1 . ASP   A 1 56  ? 8.37123   -1.88116  -23.48317 1.000 28.13603 ? 56  ASP   A OD1 1 
ATOM   431  O OD2 . ASP   A 1 56  ? 8.40296   -4.06755  -23.28597 1.000 31.57030 ? 56  ASP   A OD2 1 
ATOM   432  N N   . LEU   A 1 57  ? 3.37947   -2.10609  -22.40654 1.000 21.31816 ? 57  LEU   A N   1 
ATOM   433  C CA  . LEU   A 1 57  ? 2.05471   -1.76124  -22.90060 1.000 20.37954 ? 57  LEU   A CA  1 
ATOM   434  C C   . LEU   A 1 57  ? 1.46984   -0.54911  -22.18052 1.000 20.38624 ? 57  LEU   A C   1 
ATOM   435  O O   . LEU   A 1 57  ? 0.57988   0.10970   -22.73035 1.000 22.55072 ? 57  LEU   A O   1 
ATOM   436  C CB  . LEU   A 1 57  ? 1.11699   -2.97129  -22.77300 1.000 24.61663 ? 57  LEU   A CB  1 
ATOM   437  C CG  . LEU   A 1 57  ? 1.47073   -4.25802  -23.54242 1.000 27.58626 ? 57  LEU   A CG  1 
ATOM   438  C CD1 . LEU   A 1 57  ? 0.82596   -5.49305  -22.91597 1.000 23.04803 ? 57  LEU   A CD1 1 
ATOM   439  C CD2 . LEU   A 1 57  ? 1.10703   -4.16053  -25.03307 1.000 27.29324 ? 57  LEU   A CD2 1 
ATOM   440  N N   . LEU   A 1 58  ? 1.96120   -0.22928  -20.97818 1.000 19.36303 ? 58  LEU   A N   1 
ATOM   441  C CA  . LEU   A 1 58  ? 1.40661   0.88056   -20.20489 1.000 22.52801 ? 58  LEU   A CA  1 
ATOM   442  C C   . LEU   A 1 58  ? 2.03241   2.22217   -20.59256 1.000 21.80749 ? 58  LEU   A C   1 
ATOM   443  O O   . LEU   A 1 58  ? 1.32524   3.23482   -20.67057 1.000 21.24412 ? 58  LEU   A O   1 
ATOM   444  C CB  . LEU   A 1 58  ? 1.58834   0.62508   -18.70605 1.000 19.75617 ? 58  LEU   A CB  1 
ATOM   445  C CG  . LEU   A 1 58  ? 1.14776   1.75503   -17.76249 1.000 17.66849 ? 58  LEU   A CG  1 
ATOM   446  C CD1 . LEU   A 1 58  ? -0.33183  2.08700   -17.94944 1.000 18.94195 ? 58  LEU   A CD1 1 
ATOM   447  C CD2 . LEU   A 1 58  ? 1.42397   1.39302   -16.32053 1.000 23.18635 ? 58  LEU   A CD2 1 
ATOM   448  N N   . ILE   A 1 59  ? 3.35124   2.26157   -20.81352 1.000 24.22222 ? 59  ILE   A N   1 
ATOM   449  C CA  . ILE   A 1 59  ? 3.99203   3.48926   -21.29087 1.000 21.95792 ? 59  ILE   A CA  1 
ATOM   450  C C   . ILE   A 1 59  ? 3.45988   3.92754   -22.65540 1.000 23.24200 ? 59  ILE   A C   1 
ATOM   451  O O   . ILE   A 1 59  ? 3.55289   5.11182   -22.99466 1.000 22.98360 ? 59  ILE   A O   1 
ATOM   452  C CB  . ILE   A 1 59  ? 5.52757   3.33717   -21.33851 1.000 20.60616 ? 59  ILE   A CB  1 
ATOM   453  C CG1 . ILE   A 1 59  ? 6.16724   4.69424   -21.59219 1.000 27.65230 ? 59  ILE   A CG1 1 
ATOM   454  C CG2 . ILE   A 1 59  ? 5.94288   2.36037   -22.44415 1.000 20.60331 ? 59  ILE   A CG2 1 
ATOM   455  C CD1 . ILE   A 1 59  ? 5.91570   5.70651   -20.47742 1.000 27.10857 ? 59  ILE   A CD1 1 
ATOM   456  N N   . ARG   A 1 60  ? 2.89844   3.00404   -23.44586 1.000 21.37168 ? 60  ARG   A N   1 
ATOM   457  C CA  . ARG   A 1 60  ? 2.22339   3.32355   -24.69973 1.000 22.38081 ? 60  ARG   A CA  1 
ATOM   458  C C   . ARG   A 1 60  ? 0.83052   3.90899   -24.50451 1.000 26.24766 ? 60  ARG   A C   1 
ATOM   459  O O   . ARG   A 1 60  ? 0.17890   4.22860   -25.50282 1.000 23.53141 ? 60  ARG   A O   1 
ATOM   460  C CB  . ARG   A 1 60  ? 2.10372   2.07320   -25.57484 1.000 22.56711 ? 60  ARG   A CB  1 
ATOM   461  C CG  . ARG   A 1 60  ? 3.43579   1.53319   -26.06924 1.000 19.37983 ? 60  ARG   A CG  1 
ATOM   462  C CD  . ARG   A 1 60  ? 3.28276   0.31804   -26.97886 1.000 22.04234 ? 60  ARG   A CD  1 
ATOM   463  N NE  . ARG   A 1 60  ? 4.59962   -0.18836  -27.36591 1.000 17.32802 ? 60  ARG   A NE  1 
ATOM   464  C CZ  . ARG   A 1 60  ? 5.23139   -1.16394  -26.72159 1.000 27.05586 ? 60  ARG   A CZ  1 
ATOM   465  N NH1 . ARG   A 1 60  ? 4.64007   -1.75028  -25.69349 1.000 33.66935 ? 60  ARG   A NH1 1 
ATOM   466  N NH2 . ARG   A 1 60  ? 6.43740   -1.56957  -27.10482 1.000 26.01724 ? 60  ARG   A NH2 1 
ATOM   467  N N   . LYS   A 1 61  ? 0.35236   4.04964   -23.26941 1.000 22.52084 ? 61  LYS   A N   1 
ATOM   468  C CA  . LYS   A 1 61  ? -0.98631  4.55931   -22.98543 1.000 26.89949 ? 61  LYS   A CA  1 
ATOM   469  C C   . LYS   A 1 61  ? -0.92985  5.95638   -22.37652 1.000 25.16540 ? 61  LYS   A C   1 
ATOM   470  O O   . LYS   A 1 61  ? 0.10481   6.39618   -21.87684 1.000 25.77204 ? 61  LYS   A O   1 
ATOM   471  C CB  . LYS   A 1 61  ? -1.74648  3.63241   -22.02783 1.000 24.92083 ? 61  LYS   A CB  1 
ATOM   472  C CG  . LYS   A 1 61  ? -1.94547  2.21780   -22.52180 1.000 24.24487 ? 61  LYS   A CG  1 
ATOM   473  C CD  . LYS   A 1 61  ? -3.00087  2.15920   -23.63244 1.000 23.52130 ? 61  LYS   A CD  1 
ATOM   474  C CE  . LYS   A 1 61  ? -3.26722  0.71804   -24.04034 1.000 21.97490 ? 61  LYS   A CE  1 
ATOM   475  N NZ  . LYS   A 1 61  ? -4.19218  0.63814   -25.18305 1.000 14.80630 ? 61  LYS   A NZ  1 
ATOM   476  N N   . SER   A 1 62  ? -2.08254  6.62745   -22.37650 1.000 25.46982 ? 62  SER   A N   1 
ATOM   477  C CA  . SER   A 1 62  ? -2.22480  8.02134   -21.96975 1.000 28.34159 ? 62  SER   A CA  1 
ATOM   478  C C   . SER   A 1 62  ? -3.27477  8.14143   -20.86239 1.000 24.25731 ? 62  SER   A C   1 
ATOM   479  O O   . SER   A 1 62  ? -3.98429  7.18891   -20.54425 1.000 21.39730 ? 62  SER   A O   1 
ATOM   480  C CB  . SER   A 1 62  ? -2.63112  8.89047   -23.17274 1.000 34.00425 ? 62  SER   A CB  1 
ATOM   481  O OG  . SER   A 1 62  ? -1.74472  8.72688   -24.27950 1.000 35.92068 ? 62  SER   A OG  1 
ATOM   482  N N   . ASN   A 1 63  ? -3.39020  9.33781   -20.27744 1.000 23.08915 ? 63  ASN   A N   1 
ATOM   483  C CA  . ASN   A 1 63  ? -4.48121  9.58610   -19.33429 1.000 27.45744 ? 63  ASN   A CA  1 
ATOM   484  C C   . ASN   A 1 63  ? -5.84250  9.49528   -20.02585 1.000 25.20537 ? 63  ASN   A C   1 
ATOM   485  O O   . ASN   A 1 63  ? -6.79809  8.94574   -19.46500 1.000 26.65610 ? 63  ASN   A O   1 
ATOM   486  C CB  . ASN   A 1 63  ? -4.32904  10.95961  -18.67088 1.000 35.95948 ? 63  ASN   A CB  1 
ATOM   487  C CG  . ASN   A 1 63  ? -3.52350  10.92629  -17.36573 1.000 32.57925 ? 63  ASN   A CG  1 
ATOM   488  O OD1 . ASN   A 1 63  ? -3.30492  9.87415   -16.75467 1.000 24.16768 ? 63  ASN   A OD1 1 
ATOM   489  N ND2 . ASN   A 1 63  ? -3.11100  12.10831  -16.91944 1.000 25.68106 ? 63  ASN   A ND2 1 
ATOM   490  N N   . HIS   A 1 64  ? -5.94036  9.96513   -21.26804 1.000 29.01297 ? 64  HIS   A N   1 
ATOM   491  C CA  . HIS   A 1 64  ? -7.23348  9.96759   -21.95329 1.000 27.65818 ? 64  HIS   A CA  1 
ATOM   492  C C   . HIS   A 1 64  ? -7.61071  8.60926   -22.54503 1.000 25.29522 ? 64  HIS   A C   1 
ATOM   493  O O   . HIS   A 1 64  ? -8.79163  8.39559   -22.83920 1.000 24.87357 ? 64  HIS   A O   1 
ATOM   494  C CB  . HIS   A 1 64  ? -7.24282  11.02784  -23.04987 1.000 26.64582 ? 64  HIS   A CB  1 
ATOM   495  C CG  . HIS   A 1 64  ? -6.67718  10.55366  -24.34933 1.000 34.27674 ? 64  HIS   A CG  1 
ATOM   496  N ND1 . HIS   A 1 64  ? -7.44916  9.96635   -25.33043 1.000 36.46822 ? 64  HIS   A ND1 1 
ATOM   497  C CD2 . HIS   A 1 64  ? -5.41143  10.57648  -24.82980 1.000 39.52971 ? 64  HIS   A CD2 1 
ATOM   498  C CE1 . HIS   A 1 64  ? -6.68299  9.64938   -26.35879 1.000 38.56112 ? 64  HIS   A CE1 1 
ATOM   499  N NE2 . HIS   A 1 64  ? -5.44171  10.00868  -26.08106 1.000 34.31900 ? 64  HIS   A NE2 1 
ATOM   500  N N   . ASN   A 1 65  ? -6.64827  7.69373   -22.73333 1.000 21.23441 ? 65  ASN   A N   1 
ATOM   501  C CA  . ASN   A 1 65  ? -6.96932  6.33772   -23.18654 1.000 29.20370 ? 65  ASN   A CA  1 
ATOM   502  C C   . ASN   A 1 65  ? -7.93211  5.61275   -22.24321 1.000 22.89052 ? 65  ASN   A C   1 
ATOM   503  O O   . ASN   A 1 65  ? -8.53129  4.60346   -22.64059 1.000 21.91699 ? 65  ASN   A O   1 
ATOM   504  C CB  . ASN   A 1 65  ? -5.69545  5.48844   -23.32438 1.000 26.88882 ? 65  ASN   A CB  1 
ATOM   505  C CG  . ASN   A 1 65  ? -4.94563  5.73920   -24.61790 1.000 28.93948 ? 65  ASN   A CG  1 
ATOM   506  O OD1 . ASN   A 1 65  ? -3.71472  5.78297   -24.64299 1.000 27.26525 ? 65  ASN   A OD1 1 
ATOM   507  N ND2 . ASN   A 1 65  ? -5.68557  5.90241   -25.70026 1.000 33.88504 ? 65  ASN   A ND2 1 
ATOM   508  N N   . PHE   A 1 66  ? -8.08207  6.09465   -21.01021 1.000 22.38509 ? 66  PHE   A N   1 
ATOM   509  C CA  . PHE   A 1 66  ? -8.86440  5.42851   -19.97242 1.000 20.51419 ? 66  PHE   A CA  1 
ATOM   510  C C   . PHE   A 1 66  ? -10.14964 6.21649   -19.74789 1.000 24.62883 ? 66  PHE   A C   1 
ATOM   511  O O   . PHE   A 1 66  ? -10.10641 7.39909   -19.40122 1.000 29.81562 ? 66  PHE   A O   1 
ATOM   512  C CB  . PHE   A 1 66  ? -8.08417  5.33046   -18.65654 1.000 20.72607 ? 66  PHE   A CB  1 
ATOM   513  C CG  . PHE   A 1 66  ? -6.85262  4.44036   -18.70379 1.000 19.14187 ? 66  PHE   A CG  1 
ATOM   514  C CD1 . PHE   A 1 66  ? -6.97798  3.06340   -18.71857 1.000 20.17499 ? 66  PHE   A CD1 1 
ATOM   515  C CD2 . PHE   A 1 66  ? -5.57349  4.98660   -18.63374 1.000 22.51160 ? 66  PHE   A CD2 1 
ATOM   516  C CE1 . PHE   A 1 66  ? -5.85921  2.25800   -18.73886 1.000 19.80351 ? 66  PHE   A CE1 1 
ATOM   517  C CE2 . PHE   A 1 66  ? -4.44421  4.19349   -18.65432 1.000 18.62955 ? 66  PHE   A CE2 1 
ATOM   518  C CZ  . PHE   A 1 66  ? -4.58568  2.82453   -18.69959 1.000 26.66132 ? 66  PHE   A CZ  1 
ATOM   519  N N   . LEU   A 1 67  ? -11.28654 5.56908   -19.93554 1.000 21.54508 ? 67  LEU   A N   1 
ATOM   520  C CA  . LEU   A 1 67  ? -12.57842 6.18260   -19.67935 1.000 24.91249 ? 67  LEU   A CA  1 
ATOM   521  C C   . LEU   A 1 67  ? -13.15916 5.58608   -18.40940 1.000 24.90176 ? 67  LEU   A C   1 
ATOM   522  O O   . LEU   A 1 67  ? -13.25347 4.36223   -18.29170 1.000 26.73854 ? 67  LEU   A O   1 
ATOM   523  C CB  . LEU   A 1 67  ? -13.51468 5.95645   -20.86269 1.000 21.19375 ? 67  LEU   A CB  1 
ATOM   524  C CG  . LEU   A 1 67  ? -13.03712 6.85514   -22.00502 1.000 31.35789 ? 67  LEU   A CG  1 
ATOM   525  C CD1 . LEU   A 1 67  ? -13.32643 6.24745   -23.38540 1.000 25.08534 ? 67  LEU   A CD1 1 
ATOM   526  C CD2 . LEU   A 1 67  ? -13.63375 8.26105   -21.86302 1.000 35.87721 ? 67  LEU   A CD2 1 
ATOM   527  N N   . VAL   A 1 68  ? -13.53149 6.43700   -17.45767 1.000 27.91368 ? 68  VAL   A N   1 
ATOM   528  C CA  . VAL   A 1 68  ? -14.13189 5.97739   -16.21322 1.000 22.77096 ? 68  VAL   A CA  1 
ATOM   529  C C   . VAL   A 1 68  ? -15.52763 6.58481   -16.11816 1.000 26.87941 ? 68  VAL   A C   1 
ATOM   530  O O   . VAL   A 1 68  ? -15.73253 7.75266   -16.47639 1.000 23.73466 ? 68  VAL   A O   1 
ATOM   531  C CB  . VAL   A 1 68  ? -13.27007 6.35281   -14.98833 1.000 20.95727 ? 68  VAL   A CB  1 
ATOM   532  C CG1 . VAL   A 1 68  ? -13.86401 5.76491   -13.72098 1.000 18.79955 ? 68  VAL   A CG1 1 
ATOM   533  C CG2 . VAL   A 1 68  ? -11.83221 5.91094   -15.19243 1.000 21.44268 ? 68  VAL   A CG2 1 
ATOM   534  N N   . GLN   A 1 69  ? -16.50196 5.78385   -15.67967 1.000 20.78710 ? 69  GLN   A N   1 
ATOM   535  C CA  . GLN   A 1 69  ? -17.87914 6.25794   -15.56228 1.000 27.45595 ? 69  GLN   A CA  1 
ATOM   536  C C   . GLN   A 1 69  ? -18.50069 5.71593   -14.28422 1.000 22.58591 ? 69  GLN   A C   1 
ATOM   537  O O   . GLN   A 1 69  ? -18.57601 4.49853   -14.08760 1.000 18.92971 ? 69  GLN   A O   1 
ATOM   538  C CB  . GLN   A 1 69  ? -18.70396 5.87796   -16.80262 1.000 26.01425 ? 69  GLN   A CB  1 
ATOM   539  C CG  . GLN   A 1 69  ? -17.97075 6.20653   -18.10794 1.000 28.89467 ? 69  GLN   A CG  1 
ATOM   540  C CD  . GLN   A 1 69  ? -18.80814 6.04394   -19.34680 1.000 42.42748 ? 69  GLN   A CD  1 
ATOM   541  O OE1 . GLN   A 1 69  ? -19.99386 6.38290   -19.35320 1.000 49.97480 ? 69  GLN   A OE1 1 
ATOM   542  N NE2 . GLN   A 1 69  ? -18.18875 5.54075   -20.42517 1.000 31.77880 ? 69  GLN   A NE2 1 
ATOM   543  N N   . ALA   A 1 70  ? -18.91044 6.62482   -13.40311 1.000 18.64769 ? 70  ALA   A N   1 
ATOM   544  C CA  . ALA   A 1 70  ? -19.53905 6.26770   -12.13472 1.000 22.21336 ? 70  ALA   A CA  1 
ATOM   545  C C   . ALA   A 1 70  ? -21.03823 6.48501   -12.30449 1.000 22.83440 ? 70  ALA   A C   1 
ATOM   546  O O   . ALA   A 1 70  ? -21.55546 7.58304   -12.08882 1.000 24.01974 ? 70  ALA   A O   1 
ATOM   547  C CB  . ALA   A 1 70  ? -18.96015 7.09429   -10.99521 1.000 21.83963 ? 70  ALA   A CB  1 
ATOM   548  N N   . GLY   A 1 71  ? -21.73351 5.42636   -12.70296 1.000 18.13373 ? 71  GLY   A N   1 
ATOM   549  C CA  . GLY   A 1 71  ? -23.11732 5.57630   -13.10993 1.000 29.13771 ? 71  GLY   A CA  1 
ATOM   550  C C   . GLY   A 1 71  ? -23.18835 6.50363   -14.30799 1.000 32.73350 ? 71  GLY   A C   1 
ATOM   551  O O   . GLY   A 1 71  ? -22.52617 6.28822   -15.33193 1.000 33.95939 ? 71  GLY   A O   1 
ATOM   552  N N   . ASN   A 1 72  ? -23.96791 7.57774   -14.17297 1.000 37.43628 ? 72  ASN   A N   1 
ATOM   553  C CA  . ASN   A 1 72  ? -24.16523 8.55561   -15.23729 1.000 45.09374 ? 72  ASN   A CA  1 
ATOM   554  C C   . ASN   A 1 72  ? -23.26540 9.77653   -15.08003 1.000 37.12932 ? 72  ASN   A C   1 
ATOM   555  O O   . ASN   A 1 72  ? -23.61011 10.87228  -15.53391 1.000 49.24212 ? 72  ASN   A O   1 
ATOM   556  C CB  . ASN   A 1 72  ? -25.63546 8.97136   -15.29400 1.000 45.11875 ? 72  ASN   A CB  1 
ATOM   557  C CG  . ASN   A 1 72  ? -26.20115 9.30377   -13.92659 1.000 38.03266 ? 72  ASN   A CG  1 
ATOM   558  O OD1 . ASN   A 1 72  ? -25.72353 10.21095  -13.24290 1.000 49.34250 ? 72  ASN   A OD1 1 
ATOM   559  N ND2 . ASN   A 1 72  ? -27.20703 8.54519   -13.50747 1.000 27.71034 ? 72  ASN   A ND2 1 
ATOM   560  N N   . VAL   A 1 73  ? -22.11893 9.60779   -14.43620 1.000 43.31550 ? 73  VAL   A N   1 
ATOM   561  C CA  . VAL   A 1 73  ? -21.17014 10.68562  -14.19976 1.000 39.98233 ? 73  VAL   A CA  1 
ATOM   562  C C   . VAL   A 1 73  ? -19.81596 10.20976  -14.69782 1.000 31.10263 ? 73  VAL   A C   1 
ATOM   563  O O   . VAL   A 1 73  ? -19.39288 9.09688   -14.37689 1.000 25.46652 ? 73  VAL   A O   1 
ATOM   564  C CB  . VAL   A 1 73  ? -21.11060 11.06999  -12.70515 1.000 37.87642 ? 73  VAL   A CB  1 
ATOM   565  C CG1 . VAL   A 1 73  ? -19.91583 11.96994  -12.41256 1.000 37.19332 ? 73  VAL   A CG1 1 
ATOM   566  C CG2 . VAL   A 1 73  ? -22.40591 11.73865  -12.27689 1.000 41.95096 ? 73  VAL   A CG2 1 
ATOM   567  N N   . GLN   A 1 74  ? -19.14557 11.03849  -15.48339 1.000 33.69790 ? 74  GLN   A N   1 
ATOM   568  C CA  . GLN   A 1 74  ? -17.87013 10.67861  -16.08969 1.000 34.90318 ? 74  GLN   A CA  1 
ATOM   569  C C   . GLN   A 1 74  ? -16.71780 11.25348  -15.26933 1.000 33.61750 ? 74  GLN   A C   1 
ATOM   570  O O   . GLN   A 1 74  ? -16.77888 12.39686  -14.80670 1.000 34.69097 ? 74  GLN   A O   1 
ATOM   571  C CB  . GLN   A 1 74  ? -17.81803 11.18811  -17.53285 1.000 36.61521 ? 74  GLN   A CB  1 
ATOM   572  C CG  . GLN   A 1 74  ? -16.82175 10.49251  -18.44062 1.000 36.08501 ? 74  GLN   A CG  1 
ATOM   573  C CD  . GLN   A 1 74  ? -17.06366 10.83543  -19.90339 1.000 42.61250 ? 74  GLN   A CD  1 
ATOM   574  O OE1 . GLN   A 1 74  ? -18.20850 10.84851  -20.36207 1.000 38.48976 ? 74  GLN   A OE1 1 
ATOM   575  N NE2 . GLN   A 1 74  ? -15.99079 11.13908  -20.63646 1.000 44.66006 ? 74  GLN   A NE2 1 
ATOM   576  N N   . LEU   A 1 75  ? -15.67401 10.45698  -15.06908 1.000 29.63551 ? 75  LEU   A N   1 
ATOM   577  C CA  . LEU   A 1 75  ? -14.53833 10.90275  -14.27360 1.000 30.01115 ? 75  LEU   A CA  1 
ATOM   578  C C   . LEU   A 1 75  ? -13.36983 11.24132  -15.18272 1.000 34.94720 ? 75  LEU   A C   1 
ATOM   579  O O   . LEU   A 1 75  ? -13.10948 10.53663  -16.16355 1.000 31.41729 ? 75  LEU   A O   1 
ATOM   580  C CB  . LEU   A 1 75  ? -14.11206 9.84621   -13.25353 1.000 23.81113 ? 75  LEU   A CB  1 
ATOM   581  C CG  . LEU   A 1 75  ? -15.08574 9.61787   -12.09951 1.000 19.43721 ? 75  LEU   A CG  1 
ATOM   582  C CD1 . LEU   A 1 75  ? -14.50740 8.67901   -11.07715 1.000 22.49949 ? 75  LEU   A CD1 1 
ATOM   583  C CD2 . LEU   A 1 75  ? -15.44459 10.93608  -11.45640 1.000 32.44123 ? 75  LEU   A CD2 1 
ATOM   584  N N   . ARG   A 1 76  ? -12.68000 12.33545  -14.85474 1.000 39.59106 ? 76  ARG   A N   1 
ATOM   585  C CA  . ARG   A 1 76  ? -11.48207 12.73603  -15.58146 1.000 31.63565 ? 76  ARG   A CA  1 
ATOM   586  C C   . ARG   A 1 76  ? -10.27906 11.99638  -15.01930 1.000 23.07438 ? 76  ARG   A C   1 
ATOM   587  O O   . ARG   A 1 76  ? -9.97297  12.12116  -13.82860 1.000 25.41191 ? 76  ARG   A O   1 
ATOM   588  C CB  . ARG   A 1 76  ? -11.25693 14.24759  -15.49394 1.000 28.01474 ? 76  ARG   A CB  1 
ATOM   589  C CG  . ARG   A 1 76  ? -9.95432  14.63122  -16.19507 1.000 29.69007 ? 76  ARG   A CG  1 
ATOM   590  C CD  . ARG   A 1 76  ? -9.81139  16.08002  -16.58769 1.000 24.29384 ? 76  ARG   A CD  1 
ATOM   591  N NE  . ARG   A 1 76  ? -8.61955  16.22587  -17.43167 1.000 37.29142 ? 76  ARG   A NE  1 
ATOM   592  C CZ  . ARG   A 1 76  ? -8.58819  16.01952  -18.75067 1.000 28.72125 ? 76  ARG   A CZ  1 
ATOM   593  N NH1 . ARG   A 1 76  ? -9.69023  15.68321  -19.41028 1.000 32.78285 ? 76  ARG   A NH1 1 
ATOM   594  N NH2 . ARG   A 1 76  ? -7.45166  16.16164  -19.42100 1.000 29.39378 ? 76  ARG   A NH2 1 
ATOM   595  N N   . VAL   A 1 77  ? -9.59972  11.22434  -15.86025 1.000 18.63374 ? 77  VAL   A N   1 
ATOM   596  C CA  . VAL   A 1 77  ? -8.39322  10.52506  -15.42255 1.000 28.58712 ? 77  VAL   A CA  1 
ATOM   597  C C   . VAL   A 1 77  ? -7.20851  11.49170  -15.47665 1.000 26.74523 ? 77  VAL   A C   1 
ATOM   598  O O   . VAL   A 1 77  ? -6.84572  11.98694  -16.55058 1.000 27.40196 ? 77  VAL   A O   1 
ATOM   599  C CB  . VAL   A 1 77  ? -8.13334  9.27680   -16.27955 1.000 31.51291 ? 77  VAL   A CB  1 
ATOM   600  C CG1 . VAL   A 1 77  ? -6.71067  8.77649   -16.07195 1.000 25.80517 ? 77  VAL   A CG1 1 
ATOM   601  C CG2 . VAL   A 1 77  ? -9.15126  8.17243   -15.95955 1.000 30.43164 ? 77  VAL   A CG2 1 
ATOM   602  N N   . ILE   A 1 78  ? -6.59580  11.75437  -14.31886 1.000 20.31623 ? 78  ILE   A N   1 
ATOM   603  C CA  . ILE   A 1 78  ? -5.46780  12.67918  -14.22415 1.000 26.71809 ? 78  ILE   A CA  1 
ATOM   604  C C   . ILE   A 1 78  ? -4.14350  11.97941  -13.91767 1.000 29.14554 ? 78  ILE   A C   1 
ATOM   605  O O   . ILE   A 1 78  ? -3.10362  12.65381  -13.85977 1.000 31.69280 ? 78  ILE   A O   1 
ATOM   606  C CB  . ILE   A 1 78  ? -5.73511  13.80327  -13.19859 1.000 29.90995 ? 78  ILE   A CB  1 
ATOM   607  C CG1 . ILE   A 1 78  ? -5.49068  13.33590  -11.76519 1.000 32.34371 ? 78  ILE   A CG1 1 
ATOM   608  C CG2 . ILE   A 1 78  ? -7.17090  14.34623  -13.31496 1.000 26.92449 ? 78  ILE   A CG2 1 
ATOM   609  C CD1 . ILE   A 1 78  ? -5.62245  14.45785  -10.71366 1.000 21.75486 ? 78  ILE   A CD1 1 
ATOM   610  N N   . GLY   A 1 79  ? -4.13368  10.65891  -13.74556 1.000 27.75124 ? 79  GLY   A N   1 
ATOM   611  C CA  . GLY   A 1 79  ? -2.88480  9.93731   -13.54761 1.000 25.21244 ? 79  GLY   A CA  1 
ATOM   612  C C   . GLY   A 1 79  ? -3.11169  8.44307   -13.56564 1.000 24.23726 ? 79  GLY   A C   1 
ATOM   613  O O   . GLY   A 1 79  ? -4.21755  7.96502   -13.29608 1.000 28.51696 ? 79  GLY   A O   1 
ATOM   614  N N   . HIS   A 1 80  ? -2.04375  7.70413   -13.88503 1.000 23.57126 ? 80  HIS   A N   1 
ATOM   615  C CA  . HIS   A 1 80  ? -2.13743  6.25220   -13.98825 1.000 16.40659 ? 80  HIS   A CA  1 
ATOM   616  C C   . HIS   A 1 80  ? -0.79116  5.62227   -13.67950 1.000 21.58163 ? 80  HIS   A C   1 
ATOM   617  O O   . HIS   A 1 80  ? 0.25769   6.16523   -14.02953 1.000 22.92821 ? 80  HIS   A O   1 
ATOM   618  C CB  . HIS   A 1 80  ? -2.57381  5.81864   -15.38457 1.000 24.22808 ? 80  HIS   A CB  1 
ATOM   619  C CG  . HIS   A 1 80  ? -1.66885  6.31915   -16.46585 1.000 25.29479 ? 80  HIS   A CG  1 
ATOM   620  N ND1 . HIS   A 1 80  ? -1.50557  7.65973   -16.73383 1.000 23.56743 ? 80  HIS   A ND1 1 
ATOM   621  C CD2 . HIS   A 1 80  ? -0.85369  5.65903   -17.32346 1.000 24.65953 ? 80  HIS   A CD2 1 
ATOM   622  C CE1 . HIS   A 1 80  ? -0.63231  7.80643   -17.71651 1.000 27.86199 ? 80  HIS   A CE1 1 
ATOM   623  N NE2 . HIS   A 1 80  ? -0.22662  6.60687   -18.09585 1.000 31.29821 ? 80  HIS   A NE2 1 
ATOM   624  N N   . SER   A 1 81  ? -0.82882  4.45927   -13.03876 1.000 11.24173 ? 81  SER   A N   1 
ATOM   625  C CA  . SER   A 1 81  ? 0.38508   3.72158   -12.73644 1.000 10.60771 ? 81  SER   A CA  1 
ATOM   626  C C   . SER   A 1 81  ? 0.01583   2.30525   -12.32966 1.000 15.53915 ? 81  SER   A C   1 
ATOM   627  O O   . SER   A 1 81  ? -1.09857  2.03092   -11.86401 1.000 13.81264 ? 81  SER   A O   1 
ATOM   628  C CB  . SER   A 1 81  ? 1.19161   4.37707   -11.61283 1.000 21.71513 ? 81  SER   A CB  1 
ATOM   629  O OG  . SER   A 1 81  ? 0.43914   4.42020   -10.41561 1.000 18.96777 ? 81  SER   A OG  1 
ATOM   630  N N   . MET   A 1 82  ? 1.00240   1.43082   -12.42600 1.000 11.58536 ? 82  MET   A N   1 
ATOM   631  C CA  . MET   A 1 82  ? 0.83204   0.01890   -12.14953 1.000 14.19487 ? 82  MET   A CA  1 
ATOM   632  C C   . MET   A 1 82  ? 1.44904   -0.31239  -10.79412 1.000 15.16689 ? 82  MET   A C   1 
ATOM   633  O O   . MET   A 1 82  ? 2.59490   0.05571   -10.51992 1.000 15.84060 ? 82  MET   A O   1 
ATOM   634  C CB  . MET   A 1 82  ? 1.48543   -0.80426  -13.25688 1.000 12.18105 ? 82  MET   A CB  1 
ATOM   635  C CG  . MET   A 1 82  ? 1.37675   -2.28265  -13.08673 1.000 11.78978 ? 82  MET   A CG  1 
ATOM   636  S SD  . MET   A 1 82  ? 1.62634   -3.00766  -14.71769 1.000 17.78614 ? 82  MET   A SD  1 
ATOM   637  C CE  . MET   A 1 82  ? 3.26472   -2.35154  -15.07366 1.000 20.15524 ? 82  MET   A CE  1 
ATOM   638  N N   . GLN   A 1 83  ? 0.68352   -0.98731  -9.95053  1.000 8.44951  ? 83  GLN   A N   1 
ATOM   639  C CA  . GLN   A 1 83  ? 1.17246   -1.54379  -8.68604  1.000 11.88016 ? 83  GLN   A CA  1 
ATOM   640  C C   . GLN   A 1 83  ? 0.95036   -3.05033  -8.77940  1.000 15.35044 ? 83  GLN   A C   1 
ATOM   641  O O   . GLN   A 1 83  ? -0.18546  -3.52034  -8.65277  1.000 9.93028  ? 83  GLN   A O   1 
ATOM   642  C CB  . GLN   A 1 83  ? 0.44644   -0.93806  -7.49482  1.000 15.14597 ? 83  GLN   A CB  1 
ATOM   643  C CG  . GLN   A 1 83  ? 1.07690   -1.22520  -6.14614  1.000 16.93078 ? 83  GLN   A CG  1 
ATOM   644  C CD  . GLN   A 1 83  ? 0.08560   -0.98708  -5.03452  1.000 25.93465 ? 83  GLN   A CD  1 
ATOM   645  O OE1 . GLN   A 1 83  ? -0.71707  -0.05865  -5.11497  1.000 37.96624 ? 83  GLN   A OE1 1 
ATOM   646  N NE2 . GLN   A 1 83  ? 0.11460   -1.82643  -3.99778  1.000 20.74537 ? 83  GLN   A NE2 1 
ATOM   647  N N   . ASN   A 1 84  ? 2.02342   -3.79669  -9.04806  1.000 7.72183  ? 84  ASN   A N   1 
ATOM   648  C CA  . ASN   A 1 84  ? 1.89480   -5.23206  -9.21566  1.000 11.55834 ? 84  ASN   A CA  1 
ATOM   649  C C   . ASN   A 1 84  ? 0.86225   -5.48354  -10.30048 1.000 9.50472  ? 84  ASN   A C   1 
ATOM   650  O O   . ASN   A 1 84  ? 0.97769   -4.92761  -11.39318 1.000 9.41332  ? 84  ASN   A O   1 
ATOM   651  C CB  . ASN   A 1 84  ? 1.52560   -5.90094  -7.88728  1.000 7.93462  ? 84  ASN   A CB  1 
ATOM   652  C CG  . ASN   A 1 84  ? 2.49904   -5.53948  -6.76382  1.000 10.63340 ? 84  ASN   A CG  1 
ATOM   653  O OD1 . ASN   A 1 84  ? 3.72521   -5.60055  -6.94704  1.000 9.36013  ? 84  ASN   A OD1 1 
ATOM   654  N ND2 . ASN   A 1 84  ? 1.95888   -5.14780  -5.60751  1.000 7.05888  ? 84  ASN   A ND2 1 
ATOM   655  N N   . CYS   A 1 85  ? -0.18964  -6.24571  -10.00458 1.000 10.52138 ? 85  CYS   A N   1 
ATOM   656  C CA  . CYS   A 1 85  ? -1.10254  -6.66223  -11.05658 1.000 13.14862 ? 85  CYS   A CA  1 
ATOM   657  C C   . CYS   A 1 85  ? -2.34921  -5.78439  -11.19924 1.000 9.59421  ? 85  CYS   A C   1 
ATOM   658  O O   . CYS   A 1 85  ? -3.28264  -6.17113  -11.90464 1.000 15.12096 ? 85  CYS   A O   1 
ATOM   659  C CB  . CYS   A 1 85  ? -1.49810  -8.11310  -10.83961 1.000 7.48291  ? 85  CYS   A CB  1 
ATOM   660  S SG  . CYS   A 1 85  ? -0.13276  -9.23480  -11.13166 1.000 8.43769  ? 85  CYS   A SG  1 
ATOM   661  N N   . VAL   A 1 86  ? -2.38891  -4.60825  -10.59209 1.000 10.75758 ? 86  VAL   A N   1 
ATOM   662  C CA  . VAL   A 1 86  ? -3.53837  -3.74252  -10.79115 1.000 7.34480  ? 86  VAL   A CA  1 
ATOM   663  C C   . VAL   A 1 86  ? -3.10028  -2.39483  -11.32299 1.000 13.76428 ? 86  VAL   A C   1 
ATOM   664  O O   . VAL   A 1 86  ? -1.93228  -1.99533  -11.24136 1.000 12.16194 ? 86  VAL   A O   1 
ATOM   665  C CB  . VAL   A 1 86  ? -4.39521  -3.55207  -9.53272  1.000 8.66466  ? 86  VAL   A CB  1 
ATOM   666  C CG1 . VAL   A 1 86  ? -5.08496  -4.87516  -9.20985  1.000 6.60590  ? 86  VAL   A CG1 1 
ATOM   667  C CG2 . VAL   A 1 86  ? -3.54249  -3.07533  -8.37171  1.000 12.12088 ? 86  VAL   A CG2 1 
ATOM   668  N N   . LEU   A 1 87  ? -4.06898  -1.71536  -11.90988 1.000 10.43734 ? 87  LEU   A N   1 
ATOM   669  C CA  . LEU   A 1 87  ? -3.87738  -0.37739  -12.42466 1.000 16.79452 ? 87  LEU   A CA  1 
ATOM   670  C C   . LEU   A 1 87  ? -4.50164  0.57675   -11.43275 1.000 14.75146 ? 87  LEU   A C   1 
ATOM   671  O O   . LEU   A 1 87  ? -5.45224  0.23080   -10.73377 1.000 10.24706 ? 87  LEU   A O   1 
ATOM   672  C CB  . LEU   A 1 87  ? -4.51137  -0.19588  -13.80000 1.000 8.53076  ? 87  LEU   A CB  1 
ATOM   673  C CG  . LEU   A 1 87  ? -3.72103  -0.22321  -15.08853 1.000 18.17523 ? 87  LEU   A CG  1 
ATOM   674  C CD1 . LEU   A 1 87  ? -4.73451  0.11991   -16.17821 1.000 18.38675 ? 87  LEU   A CD1 1 
ATOM   675  C CD2 . LEU   A 1 87  ? -2.61121  0.80190   -15.07597 1.000 17.46765 ? 87  LEU   A CD2 1 
ATOM   676  N N   . LYS   A 1 88  ? -3.95583  1.76495   -11.34128 1.000 12.41190 ? 88  LYS   A N   1 
ATOM   677  C CA  . LYS   A 1 88  ? -4.31019  2.62911   -10.23916 1.000 17.50298 ? 88  LYS   A CA  1 
ATOM   678  C C   . LYS   A 1 88  ? -4.38470  4.00666   -10.87129 1.000 23.08466 ? 88  LYS   A C   1 
ATOM   679  O O   . LYS   A 1 88  ? -3.34357  4.64235   -11.09793 1.000 23.05818 ? 88  LYS   A O   1 
ATOM   680  C CB  . LYS   A 1 88  ? -3.26936  2.45980   -9.15526  1.000 20.20887 ? 88  LYS   A CB  1 
ATOM   681  C CG  . LYS   A 1 88  ? -3.65536  2.81976   -7.82285  1.000 28.26943 ? 88  LYS   A CG  1 
ATOM   682  C CD  . LYS   A 1 88  ? -2.52654  2.26217   -6.93601  1.000 19.15939 ? 88  LYS   A CD  1 
ATOM   683  C CE  . LYS   A 1 88  ? -1.30585  3.07218   -6.88351  1.000 32.46408 ? 88  LYS   A CE  1 
ATOM   684  N NZ  . LYS   A 1 88  ? -1.63076  4.27215   -6.06996  1.000 38.26390 ? 88  LYS   A NZ  1 
ATOM   685  N N   . LEU   A 1 89  ? -5.63902  4.39371   -11.16442 1.000 20.93292 ? 89  LEU   A N   1 
ATOM   686  C CA  . LEU   A 1 89  ? -5.98523  5.52750   -12.00694 1.000 20.72575 ? 89  LEU   A CA  1 
ATOM   687  C C   . LEU   A 1 89  ? -6.41984  6.67440   -11.11121 1.000 21.00699 ? 89  LEU   A C   1 
ATOM   688  O O   . LEU   A 1 89  ? -7.48495  6.61321   -10.48537 1.000 9.89565  ? 89  LEU   A O   1 
ATOM   689  C CB  . LEU   A 1 89  ? -7.10892  5.16534   -12.97376 1.000 19.71331 ? 89  LEU   A CB  1 
ATOM   690  C CG  . LEU   A 1 89  ? -6.95804  4.09266   -14.04262 1.000 17.96581 ? 89  LEU   A CG  1 
ATOM   691  C CD1 . LEU   A 1 89  ? -8.26587  3.89738   -14.79944 1.000 13.54459 ? 89  LEU   A CD1 1 
ATOM   692  C CD2 . LEU   A 1 89  ? -5.86636  4.52004   -14.97300 1.000 18.63443 ? 89  LEU   A CD2 1 
ATOM   693  N N   . LYS   A 1 90  ? -5.59185  7.71342   -11.05058 1.000 18.67649 ? 90  LYS   A N   1 
ATOM   694  C CA  . LYS   A 1 90  ? -5.92977  8.91085   -10.30433 1.000 20.25405 ? 90  LYS   A CA  1 
ATOM   695  C C   . LYS   A 1 90  ? -7.00337  9.67104   -11.07911 1.000 20.07964 ? 90  LYS   A C   1 
ATOM   696  O O   . LYS   A 1 90  ? -6.85043  9.92379   -12.27649 1.000 19.52492 ? 90  LYS   A O   1 
ATOM   697  C CB  . LYS   A 1 90  ? -4.66889  9.74755   -10.10732 1.000 23.87497 ? 90  LYS   A CB  1 
ATOM   698  C CG  . LYS   A 1 90  ? -4.81255  10.99446  -9.26989  1.000 24.48493 ? 90  LYS   A CG  1 
ATOM   699  C CD  . LYS   A 1 90  ? -5.08118  10.70991  -7.81630  1.000 22.84242 ? 90  LYS   A CD  1 
ATOM   700  C CE  . LYS   A 1 90  ? -3.83501  10.12148  -7.16457  1.000 31.43762 ? 90  LYS   A CE  1 
ATOM   701  N NZ  . LYS   A 1 90  ? -3.94376  9.93154   -5.68902  1.000 37.94887 ? 90  LYS   A NZ  1 
ATOM   702  N N   . VAL   A 1 91  ? -8.10787  9.97958   -10.41335 1.000 21.42468 ? 91  VAL   A N   1 
ATOM   703  C CA  . VAL   A 1 91  ? -9.19018  10.75616  -10.99310 1.000 21.43367 ? 91  VAL   A CA  1 
ATOM   704  C C   . VAL   A 1 91  ? -9.26686  12.08565  -10.25294 1.000 23.07248 ? 91  VAL   A C   1 
ATOM   705  O O   . VAL   A 1 91  ? -8.70633  12.25896  -9.16827  1.000 23.31090 ? 91  VAL   A O   1 
ATOM   706  C CB  . VAL   A 1 91  ? -10.53409 9.99233   -10.93308 1.000 25.98794 ? 91  VAL   A CB  1 
ATOM   707  C CG1 . VAL   A 1 91  ? -10.52195 8.82288   -11.89432 1.000 26.64214 ? 91  VAL   A CG1 1 
ATOM   708  C CG2 . VAL   A 1 91  ? -10.79117 9.47796   -9.52705  1.000 19.67287 ? 91  VAL   A CG2 1 
ATOM   709  N N   . ASP   A 1 92  ? -9.94987  13.04689  -10.86286 1.000 29.26349 ? 92  ASP   A N   1 
ATOM   710  C CA  . ASP   A 1 92  ? -10.05853 14.37695  -10.27777 1.000 29.66343 ? 92  ASP   A CA  1 
ATOM   711  C C   . ASP   A 1 92  ? -11.17264 14.49249  -9.23339  1.000 32.84469 ? 92  ASP   A C   1 
ATOM   712  O O   . ASP   A 1 92  ? -11.46999 15.61038  -8.79484  1.000 29.61378 ? 92  ASP   A O   1 
ATOM   713  C CB  . ASP   A 1 92  ? -10.28425 15.41297  -11.37844 1.000 35.22560 ? 92  ASP   A CB  1 
ATOM   714  C CG  . ASP   A 1 92  ? -11.64422 15.27828  -12.03146 1.000 33.01569 ? 92  ASP   A CG  1 
ATOM   715  O OD1 . ASP   A 1 92  ? -12.08003 14.13618  -12.30619 1.000 27.60462 ? 92  ASP   A OD1 1 
ATOM   716  O OD2 . ASP   A 1 92  ? -12.28144 16.32820  -12.24816 1.000 39.18290 ? 92  ASP   A OD2 1 
ATOM   717  N N   . THR   A 1 93  ? -11.79379 13.38357  -8.82665  1.000 27.27176 ? 93  THR   A N   1 
ATOM   718  C CA  . THR   A 1 93  ? -12.88304 13.41949  -7.86175  1.000 21.54700 ? 93  THR   A CA  1 
ATOM   719  C C   . THR   A 1 93  ? -12.66581 12.36350  -6.78657  1.000 20.74355 ? 93  THR   A C   1 
ATOM   720  O O   . THR   A 1 93  ? -12.50423 11.17728  -7.09260  1.000 15.10565 ? 93  THR   A O   1 
ATOM   721  C CB  . THR   A 1 93  ? -14.24773 13.20699  -8.53569  1.000 30.81793 ? 93  THR   A CB  1 
ATOM   722  O OG1 . THR   A 1 93  ? -14.43490 14.16920  -9.58124  1.000 31.19835 ? 93  THR   A OG1 1 
ATOM   723  C CG2 . THR   A 1 93  ? -15.37460 13.34006  -7.51771  1.000 23.49747 ? 93  THR   A CG2 1 
ATOM   724  N N   . ALA   A 1 94  ? -12.65290 12.81186  -5.52935  1.000 22.55909 ? 94  ALA   A N   1 
ATOM   725  C CA  . ALA   A 1 94  ? -12.64217 11.93230  -4.36954  1.000 20.23056 ? 94  ALA   A CA  1 
ATOM   726  C C   . ALA   A 1 94  ? -14.04672 11.37913  -4.16525  1.000 20.85182 ? 94  ALA   A C   1 
ATOM   727  O O   . ALA   A 1 94  ? -14.99212 12.15588  -4.00017  1.000 15.10515 ? 94  ALA   A O   1 
ATOM   728  C CB  . ALA   A 1 94  ? -12.17859 12.69374  -3.12978  1.000 17.10108 ? 94  ALA   A CB  1 
ATOM   729  N N   . ASN   A 1 95  ? -14.18753 10.03291  -4.18010  1.000 20.03014 ? 95  ASN   A N   1 
ATOM   730  C CA  . ASN   A 1 95  ? -15.50812 9.40528   -4.08776  1.000 16.69750 ? 95  ASN   A CA  1 
ATOM   731  C C   . ASN   A 1 95  ? -16.26423 9.98639   -2.90443  1.000 18.07179 ? 95  ASN   A C   1 
ATOM   732  O O   . ASN   A 1 95  ? -15.85400 9.77947   -1.75552  1.000 21.35189 ? 95  ASN   A O   1 
ATOM   733  C CB  . ASN   A 1 95  ? -15.40127 7.88948   -3.93629  1.000 17.69686 ? 95  ASN   A CB  1 
ATOM   734  C CG  . ASN   A 1 95  ? -16.74649 7.19499   -4.08568  1.000 13.88712 ? 95  ASN   A CG  1 
ATOM   735  O OD1 . ASN   A 1 95  ? -17.76321 7.83588   -4.28189  1.000 10.52921 ? 95  ASN   A OD1 1 
ATOM   736  N ND2 . ASN   A 1 95  ? -16.75034 5.87770   -3.96457  1.000 12.26532 ? 95  ASN   A ND2 1 
ATOM   737  N N   . PRO   A 1 96  ? -17.35588 10.72456  -3.13492  1.000 14.27494 ? 96  PRO   A N   1 
ATOM   738  C CA  . PRO   A 1 96  ? -18.08844 11.32334  -2.00366  1.000 16.97563 ? 96  PRO   A CA  1 
ATOM   739  C C   . PRO   A 1 96  ? -18.62211 10.29373  -1.02455  1.000 19.62087 ? 96  PRO   A C   1 
ATOM   740  O O   . PRO   A 1 96  ? -19.03332 10.65920  0.07630   1.000 21.86627 ? 96  PRO   A O   1 
ATOM   741  C CB  . PRO   A 1 96  ? -19.23015 12.09168  -2.68680  1.000 18.26900 ? 96  PRO   A CB  1 
ATOM   742  C CG  . PRO   A 1 96  ? -19.33537 11.48269  -4.09055  1.000 17.03230 ? 96  PRO   A CG  1 
ATOM   743  C CD  . PRO   A 1 96  ? -17.96010 11.04840  -4.44523  1.000 11.86677 ? 96  PRO   A CD  1 
ATOM   744  N N   . LYS   A 1 97  ? -18.61727 9.01884   -1.38205  1.000 16.05312 ? 97  LYS   A N   1 
ATOM   745  C CA  . LYS   A 1 97  ? -19.15001 7.96211   -0.53608  1.000 16.33133 ? 97  LYS   A CA  1 
ATOM   746  C C   . LYS   A 1 97  ? -18.06412 6.96265   -0.15357  1.000 18.09475 ? 97  LYS   A C   1 
ATOM   747  O O   . LYS   A 1 97  ? -18.33503 5.77459   0.00579   1.000 15.40211 ? 97  LYS   A O   1 
ATOM   748  C CB  . LYS   A 1 97  ? -20.30638 7.26059   -1.24596  1.000 24.85541 ? 97  LYS   A CB  1 
ATOM   749  C CG  . LYS   A 1 97  ? -21.47176 8.19108   -1.57646  1.000 14.91545 ? 97  LYS   A CG  1 
ATOM   750  C CD  . LYS   A 1 97  ? -22.35965 7.54944   -2.60582  1.000 15.57562 ? 97  LYS   A CD  1 
ATOM   751  C CE  . LYS   A 1 97  ? -21.61258 7.29335   -3.90485  1.000 22.29085 ? 97  LYS   A CE  1 
ATOM   752  N NZ  . LYS   A 1 97  ? -20.61985 8.36573   -4.26737  1.000 23.89161 ? 97  LYS   A NZ  1 
ATOM   753  N N   . THR   A 1 98  ? -16.82970 7.43227   -0.02552  1.000 21.58619 ? 98  THR   A N   1 
ATOM   754  C CA  . THR   A 1 98  ? -15.72762 6.58000   0.41376   1.000 17.26788 ? 98  THR   A CA  1 
ATOM   755  C C   . THR   A 1 98  ? -15.97110 6.13622   1.85106   1.000 19.80707 ? 98  THR   A C   1 
ATOM   756  O O   . THR   A 1 98  ? -16.11150 6.99065   2.73781   1.000 18.30769 ? 98  THR   A O   1 
ATOM   757  C CB  . THR   A 1 98  ? -14.39697 7.33695   0.29312   1.000 14.20391 ? 98  THR   A CB  1 
ATOM   758  O OG1 . THR   A 1 98  ? -14.07850 7.52233   -1.08817  1.000 18.14167 ? 98  THR   A OG1 1 
ATOM   759  C CG2 . THR   A 1 98  ? -13.25048 6.58786   0.95939   1.000 16.16133 ? 98  THR   A CG2 1 
ATOM   760  N N   . PRO   A 1 99  ? -16.06297 4.83918   2.12559   1.000 17.44501 ? 99  PRO   A N   1 
ATOM   761  C CA  . PRO   A 1 99  ? -16.19796 4.38092   3.50940   1.000 18.52812 ? 99  PRO   A CA  1 
ATOM   762  C C   . PRO   A 1 99  ? -14.84358 4.37411   4.20830   1.000 17.67557 ? 99  PRO   A C   1 
ATOM   763  O O   . PRO   A 1 99  ? -13.79185 4.57508   3.59276   1.000 12.41463 ? 99  PRO   A O   1 
ATOM   764  C CB  . PRO   A 1 99  ? -16.72916 2.95341   3.34105   1.000 18.94328 ? 99  PRO   A CB  1 
ATOM   765  C CG  . PRO   A 1 99  ? -16.03030 2.46986   2.10138   1.000 14.08223 ? 99  PRO   A CG  1 
ATOM   766  C CD  . PRO   A 1 99  ? -15.90494 3.70650   1.19048   1.000 17.55320 ? 99  PRO   A CD  1 
ATOM   767  N N   . LYS   A 1 100 ? -14.88428 4.12470   5.51651   1.000 10.57895 ? 100 LYS   A N   1 
ATOM   768  C CA  . LYS   A 1 100 ? -13.68133 3.67289   6.20036   1.000 15.46387 ? 100 LYS   A CA  1 
ATOM   769  C C   . LYS   A 1 100 ? -13.28354 2.33569   5.59673   1.000 13.05582 ? 100 LYS   A C   1 
ATOM   770  O O   . LYS   A 1 100 ? -14.13855 1.47590   5.37771   1.000 12.94114 ? 100 LYS   A O   1 
ATOM   771  C CB  . LYS   A 1 100 ? -13.92887 3.51993   7.70434   1.000 19.24707 ? 100 LYS   A CB  1 
ATOM   772  C CG  . LYS   A 1 100 ? -13.84554 4.80860   8.52573   1.000 17.15389 ? 100 LYS   A CG  1 
ATOM   773  C CD  . LYS   A 1 100 ? -12.45791 4.99498   9.18250   1.000 27.50394 ? 100 LYS   A CD  1 
ATOM   774  C CE  . LYS   A 1 100 ? -12.30174 6.39589   9.80651   1.000 25.23029 ? 100 LYS   A CE  1 
ATOM   775  N NZ  . LYS   A 1 100 ? -11.71661 7.39254   8.85095   1.000 29.88903 ? 100 LYS   A NZ  1 
ATOM   776  N N   . TYR   A 1 101 ? -11.99494 2.15461   5.30217   1.000 11.43846 ? 101 TYR   A N   1 
ATOM   777  C CA  . TYR   A 1 101 ? -11.57604 0.89626   4.69787   1.000 12.15350 ? 101 TYR   A CA  1 
ATOM   778  C C   . TYR   A 1 101 ? -10.14993 0.56110   5.12223   1.000 16.42402 ? 101 TYR   A C   1 
ATOM   779  O O   . TYR   A 1 101 ? -9.42963  1.37776   5.71369   1.000 12.74702 ? 101 TYR   A O   1 
ATOM   780  C CB  . TYR   A 1 101 ? -11.70695 0.92345   3.15559   1.000 10.53614 ? 101 TYR   A CB  1 
ATOM   781  C CG  . TYR   A 1 101 ? -10.78515 1.92433   2.48075   1.000 14.23588 ? 101 TYR   A CG  1 
ATOM   782  C CD1 . TYR   A 1 101 ? -11.15993 3.25313   2.34595   1.000 10.17790 ? 101 TYR   A CD1 1 
ATOM   783  C CD2 . TYR   A 1 101 ? -9.52049  1.54471   2.01916   1.000 15.96532 ? 101 TYR   A CD2 1 
ATOM   784  C CE1 . TYR   A 1 101 ? -10.32364 4.17448   1.74345   1.000 16.59519 ? 101 TYR   A CE1 1 
ATOM   785  C CE2 . TYR   A 1 101 ? -8.66467  2.47238   1.43206   1.000 17.78432 ? 101 TYR   A CE2 1 
ATOM   786  C CZ  . TYR   A 1 101 ? -9.08114  3.78364   1.29360   1.000 22.23173 ? 101 TYR   A CZ  1 
ATOM   787  O OH  . TYR   A 1 101 ? -8.26483  4.71952   0.70480   1.000 32.38345 ? 101 TYR   A OH  1 
ATOM   788  N N   . LYS   A 1 102 ? -9.78653  -0.69520  4.85881   1.000 13.98452 ? 102 LYS   A N   1 
ATOM   789  C CA  . LYS   A 1 102 ? -8.43004  -1.21068  4.96660   1.000 9.95636  ? 102 LYS   A CA  1 
ATOM   790  C C   . LYS   A 1 102 ? -8.23471  -2.13444  3.78001   1.000 9.89101  ? 102 LYS   A C   1 
ATOM   791  O O   . LYS   A 1 102 ? -9.20296  -2.63971  3.20617   1.000 9.81815  ? 102 LYS   A O   1 
ATOM   792  C CB  . LYS   A 1 102 ? -8.17183  -1.98352  6.28287   1.000 10.26740 ? 102 LYS   A CB  1 
ATOM   793  C CG  . LYS   A 1 102 ? -8.75380  -1.35039  7.57434   1.000 11.07371 ? 102 LYS   A CG  1 
ATOM   794  C CD  . LYS   A 1 102 ? -8.05231  -1.85429  8.87608   1.000 15.20522 ? 102 LYS   A CD  1 
ATOM   795  C CE  . LYS   A 1 102 ? -8.71225  -3.11059  9.38784   1.000 16.82119 ? 102 LYS   A CE  1 
ATOM   796  N NZ  . LYS   A 1 102 ? -8.62693  -3.29778  10.86372  1.000 19.35940 ? 102 LYS   A NZ  1 
ATOM   797  N N   . PHE   A 1 103 ? -6.97981  -2.32371  3.39278   1.000 9.24536  ? 103 PHE   A N   1 
ATOM   798  C CA  . PHE   A 1 103 ? -6.58195  -3.35115  2.43902   1.000 4.80290  ? 103 PHE   A CA  1 
ATOM   799  C C   . PHE   A 1 103 ? -5.91368  -4.45666  3.25176   1.000 5.99399  ? 103 PHE   A C   1 
ATOM   800  O O   . PHE   A 1 103 ? -4.77918  -4.28888  3.69794   1.000 6.29549  ? 103 PHE   A O   1 
ATOM   801  C CB  . PHE   A 1 103 ? -5.59477  -2.79255  1.40027   1.000 7.72208  ? 103 PHE   A CB  1 
ATOM   802  C CG  . PHE   A 1 103 ? -6.20254  -1.90582  0.35133   1.000 6.12361  ? 103 PHE   A CG  1 
ATOM   803  C CD1 . PHE   A 1 103 ? -7.57234  -1.79193  0.20271   1.000 8.86043  ? 103 PHE   A CD1 1 
ATOM   804  C CD2 . PHE   A 1 103 ? -5.38637  -1.20535  -0.51539  1.000 8.67305  ? 103 PHE   A CD2 1 
ATOM   805  C CE1 . PHE   A 1 103 ? -8.11980  -0.96250  -0.78757  1.000 8.43822  ? 103 PHE   A CE1 1 
ATOM   806  C CE2 . PHE   A 1 103 ? -5.91307  -0.38955  -1.49572  1.000 8.16930  ? 103 PHE   A CE2 1 
ATOM   807  C CZ  . PHE   A 1 103 ? -7.28650  -0.25867  -1.62444  1.000 10.10077 ? 103 PHE   A CZ  1 
ATOM   808  N N   . VAL   A 1 104 ? -6.59607  -5.58671  3.44818   1.000 8.08354  ? 104 VAL   A N   1 
ATOM   809  C CA  . VAL   A 1 104 ? -6.00093  -6.71375  4.15771   1.000 10.00428 ? 104 VAL   A CA  1 
ATOM   810  C C   . VAL   A 1 104 ? -5.89318  -7.87439  3.19268   1.000 12.89987 ? 104 VAL   A C   1 
ATOM   811  O O   . VAL   A 1 104 ? -6.66507  -7.99024  2.23551   1.000 13.96689 ? 104 VAL   A O   1 
ATOM   812  C CB  . VAL   A 1 104 ? -6.80700  -7.16805  5.39640   1.000 12.50145 ? 104 VAL   A CB  1 
ATOM   813  C CG1 . VAL   A 1 104 ? -6.87339  -6.06877  6.48128   1.000 15.24862 ? 104 VAL   A CG1 1 
ATOM   814  C CG2 . VAL   A 1 104 ? -8.20966  -7.60328  4.96791   1.000 10.27544 ? 104 VAL   A CG2 1 
ATOM   815  N N   . ARG   A 1 105 ? -4.94838  -8.76874  3.48279   1.000 6.16472  ? 105 ARG   A N   1 
ATOM   816  C CA  . ARG   A 1 105 ? -4.84064  -10.04485 2.79027   1.000 9.92945  ? 105 ARG   A CA  1 
ATOM   817  C C   . ARG   A 1 105 ? -5.31075  -11.15174 3.71949   1.000 9.88504  ? 105 ARG   A C   1 
ATOM   818  O O   . ARG   A 1 105 ? -4.89280  -11.20192 4.87426   1.000 5.63567  ? 105 ARG   A O   1 
ATOM   819  C CB  . ARG   A 1 105 ? -3.41070  -10.32590 2.34329   1.000 8.81605  ? 105 ARG   A CB  1 
ATOM   820  C CG  . ARG   A 1 105 ? -3.31024  -11.46984 1.35379   1.000 4.12901  ? 105 ARG   A CG  1 
ATOM   821  C CD  . ARG   A 1 105 ? -1.85079  -11.71520 0.99546   1.000 4.18962  ? 105 ARG   A CD  1 
ATOM   822  N NE  . ARG   A 1 105 ? -1.68082  -12.97015 0.28854   1.000 4.17359  ? 105 ARG   A NE  1 
ATOM   823  C CZ  . ARG   A 1 105 ? -1.52285  -13.09639 -1.02536  1.000 4.26538  ? 105 ARG   A CZ  1 
ATOM   824  N NH1 . ARG   A 1 105 ? -1.52114  -12.01286 -1.77882  1.000 4.06652  ? 105 ARG   A NH1 1 
ATOM   825  N NH2 . ARG   A 1 105 ? -1.37113  -14.30305 -1.58471  1.000 0.00008  ? 105 ARG   A NH2 1 
ATOM   826  N N   . ILE   A 1 106 ? -6.15762  -12.04450 3.20714   1.000 7.07932  ? 106 ILE   A N   1 
ATOM   827  C CA  . ILE   A 1 106 ? -6.76889  -13.09389 4.01220   1.000 12.54352 ? 106 ILE   A CA  1 
ATOM   828  C C   . ILE   A 1 106 ? -5.97737  -14.38992 3.84970   1.000 10.86396 ? 106 ILE   A C   1 
ATOM   829  O O   . ILE   A 1 106 ? -5.16321  -14.55324 2.93263   1.000 7.66226  ? 106 ILE   A O   1 
ATOM   830  C CB  . ILE   A 1 106 ? -8.26093  -13.31867 3.63937   1.000 10.13004 ? 106 ILE   A CB  1 
ATOM   831  C CG1 . ILE   A 1 106 ? -8.41294  -13.38474 2.11467   1.000 7.04811  ? 106 ILE   A CG1 1 
ATOM   832  C CG2 . ILE   A 1 106 ? -9.14726  -12.23974 4.26246   1.000 9.68360  ? 106 ILE   A CG2 1 
ATOM   833  C CD1 . ILE   A 1 106 ? -9.75220  -14.04602 1.62093   1.000 9.74675  ? 106 ILE   A CD1 1 
ATOM   834  N N   . GLN   A 1 107 ? -6.20727  -15.29316 4.73683   1.000 7.31017  ? 107 GLN   A N   1 
ATOM   835  C CA  . GLN   A 1 107 ? -5.68747  -16.65591 4.73536   1.000 15.33655 ? 107 GLN   A CA  1 
ATOM   836  C C   . GLN   A 1 107 ? -6.64018  -17.58737 3.99114   1.000 10.57289 ? 107 GLN   A C   1 
ATOM   837  O O   . GLN   A 1 107 ? -7.84741  -17.31811 3.90870   1.000 8.05717  ? 107 GLN   A O   1 
ATOM   838  C CB  . GLN   A 1 107 ? -5.49297  -17.17299 6.17016   1.000 10.01480 ? 107 GLN   A CB  1 
ATOM   839  C CG  . GLN   A 1 107 ? -4.27083  -16.59153 6.88305   1.000 8.82151  ? 107 GLN   A CG  1 
ATOM   840  C CD  . GLN   A 1 107 ? -2.96559  -16.94695 6.15797   1.000 10.47915 ? 107 GLN   A CD  1 
ATOM   841  O OE1 . GLN   A 1 107 ? -2.74109  -18.10570 5.78070   1.000 7.98645  ? 107 GLN   A OE1 1 
ATOM   842  N NE2 . GLN   A 1 107 ? -2.14848  -15.93449 5.88238   1.000 4.15273  ? 107 GLN   A NE2 1 
ATOM   843  N N   . PRO   A 1 108 ? -6.14078  -18.67836 3.40173   1.000 10.02219 ? 108 PRO   A N   1 
ATOM   844  C CA  . PRO   A 1 108 ? -7.06004  -19.74974 3.00010   1.000 9.66378  ? 108 PRO   A CA  1 
ATOM   845  C C   . PRO   A 1 108 ? -7.72975  -20.29393 4.25394   1.000 9.02957  ? 108 PRO   A C   1 
ATOM   846  O O   . PRO   A 1 108 ? -7.10788  -20.39019 5.31616   1.000 9.53053  ? 108 PRO   A O   1 
ATOM   847  C CB  . PRO   A 1 108 ? -6.14892  -20.78738 2.31295   1.000 13.37306 ? 108 PRO   A CB  1 
ATOM   848  C CG  . PRO   A 1 108 ? -4.71786  -20.34699 2.58118   1.000 11.81047 ? 108 PRO   A CG  1 
ATOM   849  C CD  . PRO   A 1 108 ? -4.77009  -18.87769 2.88931   1.000 10.78836 ? 108 PRO   A CD  1 
ATOM   850  N N   . GLY   A 1 109 ? -9.01915  -20.57965 4.15438   1.000 5.55568  ? 109 GLY   A N   1 
ATOM   851  C CA  . GLY   A 1 109 ? -9.81935  -20.94709 5.31321   1.000 5.94406  ? 109 GLY   A CA  1 
ATOM   852  C C   . GLY   A 1 109 ? -10.71745 -19.84445 5.84022   1.000 4.67876  ? 109 GLY   A C   1 
ATOM   853  O O   . GLY   A 1 109 ? -11.70881 -20.14358 6.51796   1.000 11.42692 ? 109 GLY   A O   1 
ATOM   854  N N   . GLN   A 1 110 ? -10.40614 -18.58991 5.53570   1.000 6.10924  ? 110 GLN   A N   1 
ATOM   855  C CA  . GLN   A 1 110 ? -11.24672 -17.43777 5.83742   1.000 5.41615  ? 110 GLN   A CA  1 
ATOM   856  C C   . GLN   A 1 110 ? -12.24344 -17.20662 4.70702   1.000 7.06879  ? 110 GLN   A C   1 
ATOM   857  O O   . GLN   A 1 110 ? -12.06344 -17.68350 3.57602   1.000 5.06548  ? 110 GLN   A O   1 
ATOM   858  C CB  . GLN   A 1 110 ? -10.39581 -16.19138 6.05420   1.000 7.73918  ? 110 GLN   A CB  1 
ATOM   859  C CG  . GLN   A 1 110 ? -9.15807  -16.45324 6.90517   1.000 15.29791 ? 110 GLN   A CG  1 
ATOM   860  C CD  . GLN   A 1 110 ? -8.54171  -15.19295 7.54267   1.000 21.16380 ? 110 GLN   A CD  1 
ATOM   861  O OE1 . GLN   A 1 110 ? -7.67919  -14.53029 6.96164   1.000 9.81210  ? 110 GLN   A OE1 1 
ATOM   862  N NE2 . GLN   A 1 110 ? -8.97523  -14.88337 8.76244   1.000 30.52184 ? 110 GLN   A NE2 1 
ATOM   863  N N   . THR   A 1 111 ? -13.30326 -16.46579 5.03632   1.000 8.28502  ? 111 THR   A N   1 
ATOM   864  C CA  . THR   A 1 111 ? -14.46242 -16.25039 4.18964   1.000 4.54173  ? 111 THR   A CA  1 
ATOM   865  C C   . THR   A 1 111 ? -14.60739 -14.76049 3.88898   1.000 6.79442  ? 111 THR   A C   1 
ATOM   866  O O   . THR   A 1 111 ? -14.00949 -13.90699 4.55291   1.000 6.07817  ? 111 THR   A O   1 
ATOM   867  C CB  . THR   A 1 111 ? -15.72725 -16.79477 4.86986   1.000 6.42916  ? 111 THR   A CB  1 
ATOM   868  O OG1 . THR   A 1 111 ? -15.93004 -16.10461 6.11182   1.000 8.66192  ? 111 THR   A OG1 1 
ATOM   869  C CG2 . THR   A 1 111 ? -15.54935 -18.28945 5.18910   1.000 5.33014  ? 111 THR   A CG2 1 
ATOM   870  N N   . PHE   A 1 112 ? -15.41088 -14.44828 2.87755   1.000 3.95520  ? 112 PHE   A N   1 
ATOM   871  C CA  . PHE   A 1 112 ? -15.66681 -13.05440 2.55581   1.000 7.84971  ? 112 PHE   A CA  1 
ATOM   872  C C   . PHE   A 1 112 ? -16.88766 -12.95401 1.65464   1.000 7.60161  ? 112 PHE   A C   1 
ATOM   873  O O   . PHE   A 1 112 ? -17.29159 -13.91339 0.99190   1.000 9.26426  ? 112 PHE   A O   1 
ATOM   874  C CB  . PHE   A 1 112 ? -14.44634 -12.36607 1.89539   1.000 5.30434  ? 112 PHE   A CB  1 
ATOM   875  C CG  . PHE   A 1 112 ? -13.92465 -13.06161 0.65487   1.000 7.49688  ? 112 PHE   A CG  1 
ATOM   876  C CD1 . PHE   A 1 112 ? -13.13234 -14.19790 0.75881   1.000 6.49194  ? 112 PHE   A CD1 1 
ATOM   877  C CD2 . PHE   A 1 112 ? -14.19215 -12.55521 -0.61009  1.000 6.37231  ? 112 PHE   A CD2 1 
ATOM   878  C CE1 . PHE   A 1 112 ? -12.63197 -14.84359 -0.38091  1.000 13.60971 ? 112 PHE   A CE1 1 
ATOM   879  C CE2 . PHE   A 1 112 ? -13.71109 -13.18702 -1.73718  1.000 14.16284 ? 112 PHE   A CE2 1 
ATOM   880  C CZ  . PHE   A 1 112 ? -12.91963 -14.33371 -1.62597  1.000 14.21034 ? 112 PHE   A CZ  1 
ATOM   881  N N   . SER   A 1 113 ? -17.47809 -11.77468 1.65476   1.000 8.64080  ? 113 SER   A N   1 
ATOM   882  C CA  . SER   A 1 113 ? -18.56464 -11.45986 0.74278   1.000 7.78005  ? 113 SER   A CA  1 
ATOM   883  C C   . SER   A 1 113 ? -18.01556 -10.90461 -0.56385  1.000 6.33727  ? 113 SER   A C   1 
ATOM   884  O O   . SER   A 1 113 ? -17.02340 -10.17682 -0.57303  1.000 6.80223  ? 113 SER   A O   1 
ATOM   885  C CB  . SER   A 1 113 ? -19.50814 -10.45531 1.39071   1.000 5.96988  ? 113 SER   A CB  1 
ATOM   886  O OG  . SER   A 1 113 ? -19.91942 -11.00155 2.62436   1.000 6.70835  ? 113 SER   A OG  1 
ATOM   887  N N   . VAL   A 1 114 ? -18.68146 -11.25891 -1.66096  1.000 9.38795  ? 114 VAL   A N   1 
ATOM   888  C CA  . VAL   A 1 114 ? -18.39544 -10.76824 -3.00235  1.000 6.45709  ? 114 VAL   A CA  1 
ATOM   889  C C   . VAL   A 1 114 ? -19.59002 -9.97138  -3.49004  1.000 8.61962  ? 114 VAL   A C   1 
ATOM   890  O O   . VAL   A 1 114 ? -20.74221 -10.36017 -3.25734  1.000 9.09080  ? 114 VAL   A O   1 
ATOM   891  C CB  . VAL   A 1 114 ? -18.10653 -11.94083 -3.97162  1.000 5.30128  ? 114 VAL   A CB  1 
ATOM   892  C CG1 . VAL   A 1 114 ? -17.90552 -11.45263 -5.40945  1.000 9.15932  ? 114 VAL   A CG1 1 
ATOM   893  C CG2 . VAL   A 1 114 ? -16.88734 -12.72852 -3.51016  1.000 13.32347 ? 114 VAL   A CG2 1 
ATOM   894  N N   . LEU   A 1 115 ? -19.31445 -8.87951  -4.19987  1.000 8.03324  ? 115 LEU   A N   1 
ATOM   895  C CA  . LEU   A 1 115 ? -20.32810 -8.12634  -4.92229  1.000 5.15775  ? 115 LEU   A CA  1 
ATOM   896  C C   . LEU   A 1 115 ? -20.01769 -8.26040  -6.41295  1.000 6.54157  ? 115 LEU   A C   1 
ATOM   897  O O   . LEU   A 1 115 ? -19.16802 -7.54634  -6.93742  1.000 5.95672  ? 115 LEU   A O   1 
ATOM   898  C CB  . LEU   A 1 115 ? -20.32768 -6.67392  -4.46249  1.000 5.01392  ? 115 LEU   A CB  1 
ATOM   899  C CG  . LEU   A 1 115 ? -21.35715 -5.74065  -5.09842  1.000 4.16242  ? 115 LEU   A CG  1 
ATOM   900  C CD1 . LEU   A 1 115 ? -22.79899 -6.08667  -4.61706  1.000 5.65240  ? 115 LEU   A CD1 1 
ATOM   901  C CD2 . LEU   A 1 115 ? -21.01307 -4.33478  -4.75755  1.000 3.27223  ? 115 LEU   A CD2 1 
ATOM   902  N N   . ALA   A 1 116 ? -20.67902 -9.19753  -7.08712  1.000 9.16548  ? 116 ALA   A N   1 
ATOM   903  C CA  . ALA   A 1 116 ? -20.43038 -9.41991  -8.50902  1.000 10.77336 ? 116 ALA   A CA  1 
ATOM   904  C C   . ALA   A 1 116 ? -20.99353 -8.26195  -9.32736  1.000 11.80968 ? 116 ALA   A C   1 
ATOM   905  O O   . ALA   A 1 116 ? -22.01903 -7.67326  -8.96158  1.000 11.39370 ? 116 ALA   A O   1 
ATOM   906  C CB  . ALA   A 1 116 ? -21.03427 -10.75382 -8.95369  1.000 6.15485  ? 116 ALA   A CB  1 
ATOM   907  N N   . CYS   A 1 117 ? -20.31045 -7.92423  -10.43338 1.000 12.72437 ? 117 CYS   A N   1 
ATOM   908  C CA  . CYS   A 1 117 ? -20.48124 -6.61213  -11.05654 1.000 14.20542 ? 117 CYS   A CA  1 
ATOM   909  C C   . CYS   A 1 117 ? -20.23645 -6.62496  -12.56484 1.000 18.79777 ? 117 CYS   A C   1 
ATOM   910  O O   . CYS   A 1 117 ? -19.32877 -7.29845  -13.05052 1.000 20.97670 ? 117 CYS   A O   1 
ATOM   911  C CB  . CYS   A 1 117 ? -19.52912 -5.59541  -10.43168 1.000 16.82186 ? 117 CYS   A CB  1 
ATOM   912  S SG  . CYS   A 1 117 ? -20.10591 -4.72759  -8.94857  1.000 21.53189 ? 117 CYS   A SG  1 
ATOM   913  N N   . TYR   A 1 118 ? -21.03144 -5.82464  -13.29589 1.000 25.02069 ? 118 TYR   A N   1 
ATOM   914  C CA  . TYR   A 1 118 ? -20.99758 -5.74339  -14.75935 1.000 22.45796 ? 118 TYR   A CA  1 
ATOM   915  C C   . TYR   A 1 118 ? -21.22255 -4.29993  -15.20024 1.000 21.82536 ? 118 TYR   A C   1 
ATOM   916  O O   . TYR   A 1 118 ? -22.20422 -3.67231  -14.79294 1.000 23.30486 ? 118 TYR   A O   1 
ATOM   917  C CB  . TYR   A 1 118 ? -22.05121 -6.68028  -15.39704 1.000 24.90750 ? 118 TYR   A CB  1 
ATOM   918  C CG  . TYR   A 1 118 ? -21.86205 -8.11016  -14.93152 1.000 27.65808 ? 118 TYR   A CG  1 
ATOM   919  C CD1 . TYR   A 1 118 ? -22.45637 -8.56374  -13.75176 1.000 21.26400 ? 118 TYR   A CD1 1 
ATOM   920  C CD2 . TYR   A 1 118 ? -21.02575 -8.97900  -15.62515 1.000 23.13872 ? 118 TYR   A CD2 1 
ATOM   921  C CE1 . TYR   A 1 118 ? -22.23745 -9.84240  -13.28939 1.000 21.59384 ? 118 TYR   A CE1 1 
ATOM   922  C CE2 . TYR   A 1 118 ? -20.80743 -10.26320 -15.18169 1.000 23.48776 ? 118 TYR   A CE2 1 
ATOM   923  C CZ  . TYR   A 1 118 ? -21.41221 -10.69577 -14.01590 1.000 24.40267 ? 118 TYR   A CZ  1 
ATOM   924  O OH  . TYR   A 1 118 ? -21.17242 -11.98233 -13.56889 1.000 20.37950 ? 118 TYR   A OH  1 
ATOM   925  N N   . ASN   A 1 119 ? -20.30409 -3.77631  -16.02223 1.000 24.98228 ? 119 ASN   A N   1 
ATOM   926  C CA  . ASN   A 1 119 ? -20.33112 -2.37776  -16.48668 1.000 22.91132 ? 119 ASN   A CA  1 
ATOM   927  C C   . ASN   A 1 119 ? -20.51480 -1.39165  -15.33277 1.000 27.49439 ? 119 ASN   A C   1 
ATOM   928  O O   . ASN   A 1 119 ? -21.29432 -0.43776  -15.42452 1.000 27.25419 ? 119 ASN   A O   1 
ATOM   929  C CB  . ASN   A 1 119 ? -21.42646 -2.15241  -17.53157 1.000 27.27324 ? 119 ASN   A CB  1 
ATOM   930  C CG  . ASN   A 1 119 ? -21.32277 -3.09532  -18.69440 1.000 31.10819 ? 119 ASN   A CG  1 
ATOM   931  O OD1 . ASN   A 1 119 ? -20.52390 -2.88845  -19.60883 1.000 41.08673 ? 119 ASN   A OD1 1 
ATOM   932  N ND2 . ASN   A 1 119 ? -22.13465 -4.14489  -18.67279 1.000 25.15312 ? 119 ASN   A ND2 1 
ATOM   933  N N   . GLY   A 1 120 ? -19.79993 -1.62189  -14.23193 1.000 24.86396 ? 120 GLY   A N   1 
ATOM   934  C CA  . GLY   A 1 120 ? -19.93501 -0.75587  -13.06972 1.000 26.92848 ? 120 GLY   A CA  1 
ATOM   935  C C   . GLY   A 1 120 ? -21.24768 -0.84397  -12.30799 1.000 25.34444 ? 120 GLY   A C   1 
ATOM   936  O O   . GLY   A 1 120 ? -21.44367 -0.07497  -11.35724 1.000 22.97512 ? 120 GLY   A O   1 
ATOM   937  N N   . SER   A 1 121 ? -22.13879 -1.77617  -12.66680 1.000 27.64834 ? 121 SER   A N   1 
ATOM   938  C CA  . SER   A 1 121 ? -23.41489 -1.96463  -11.97463 1.000 23.84748 ? 121 SER   A CA  1 
ATOM   939  C C   . SER   A 1 121 ? -23.41915 -3.26489  -11.18844 1.000 18.24235 ? 121 SER   A C   1 
ATOM   940  O O   . SER   A 1 121 ? -23.32563 -4.34794  -11.79421 1.000 13.02871 ? 121 SER   A O   1 
ATOM   941  C CB  . SER   A 1 121 ? -24.56443 -1.96926  -12.97206 1.000 28.33557 ? 121 SER   A CB  1 
ATOM   942  O OG  . SER   A 1 121 ? -24.70793 -0.70948  -13.59287 1.000 39.08751 ? 121 SER   A OG  1 
ATOM   943  N N   . PRO   A 1 122 ? -23.55279 -3.18744  -9.86136  1.000 19.35614 ? 122 PRO   A N   1 
ATOM   944  C CA  . PRO   A 1 122 ? -23.65971 -4.40067  -9.03392  1.000 22.79740 ? 122 PRO   A CA  1 
ATOM   945  C C   . PRO   A 1 122 ? -24.85867 -5.25815  -9.42339  1.000 17.42917 ? 122 PRO   A C   1 
ATOM   946  O O   . PRO   A 1 122 ? -25.98446 -4.77326  -9.54050  1.000 12.18959 ? 122 PRO   A O   1 
ATOM   947  C CB  . PRO   A 1 122 ? -23.81698 -3.84397  -7.60952  1.000 16.62303 ? 122 PRO   A CB  1 
ATOM   948  C CG  . PRO   A 1 122 ? -23.16901 -2.49229  -7.65436  1.000 17.74847 ? 122 PRO   A CG  1 
ATOM   949  C CD  . PRO   A 1 122 ? -23.44783 -1.96003  -9.04782  1.000 20.18364 ? 122 PRO   A CD  1 
ATOM   950  N N   . SER   A 1 123 ? -24.61768 -6.55837  -9.55574  1.000 15.90661 ? 123 SER   A N   1 
ATOM   951  C CA  . SER   A 1 123 ? -25.65591 -7.48802  -9.96216  1.000 10.80115 ? 123 SER   A CA  1 
ATOM   952  C C   . SER   A 1 123 ? -26.13041 -8.41729  -8.84779  1.000 8.58993  ? 123 SER   A C   1 
ATOM   953  O O   . SER   A 1 123 ? -27.32278 -8.75531  -8.81833  1.000 8.05981  ? 123 SER   A O   1 
ATOM   954  C CB  . SER   A 1 123 ? -25.15010 -8.33205  -11.14138 1.000 15.65196 ? 123 SER   A CB  1 
ATOM   955  O OG  . SER   A 1 123 ? -26.22600 -8.87626  -11.87831 1.000 31.76840 ? 123 SER   A OG  1 
ATOM   956  N N   . GLY   A 1 124 ? -25.23356 -8.84592  -7.93986  1.000 9.44168  ? 124 GLY   A N   1 
ATOM   957  C CA  . GLY   A 1 124 ? -25.56264 -9.79137  -6.87630  1.000 7.01164  ? 124 GLY   A CA  1 
ATOM   958  C C   . GLY   A 1 124 ? -24.50892 -9.81062  -5.78515  1.000 7.56118  ? 124 GLY   A C   1 
ATOM   959  O O   . GLY   A 1 124 ? -23.42337 -9.24836  -5.93590  1.000 9.27197  ? 124 GLY   A O   1 
ATOM   960  N N   . VAL   A 1 125 ? -24.85927 -10.43140 -4.65003  1.000 9.68915  ? 125 VAL   A N   1 
ATOM   961  C CA  . VAL   A 1 125 ? -23.96351 -10.51687 -3.49413  1.000 6.58843  ? 125 VAL   A CA  1 
ATOM   962  C C   . VAL   A 1 125 ? -24.03066 -11.93521 -2.93632  1.000 8.47541  ? 125 VAL   A C   1 
ATOM   963  O O   . VAL   A 1 125 ? -25.10450 -12.54266 -2.87756  1.000 10.32502 ? 125 VAL   A O   1 
ATOM   964  C CB  . VAL   A 1 125 ? -24.29823 -9.47806  -2.39875  1.000 8.64701  ? 125 VAL   A CB  1 
ATOM   965  C CG1 . VAL   A 1 125 ? -25.64781 -9.78055  -1.74924  1.000 6.84084  ? 125 VAL   A CG1 1 
ATOM   966  C CG2 . VAL   A 1 125 ? -23.21241 -9.47559  -1.31520  1.000 5.97096  ? 125 VAL   A CG2 1 
ATOM   967  N N   . TYR   A 1 126 ? -22.87895 -12.47449 -2.54804  1.000 9.33890  ? 126 TYR   A N   1 
ATOM   968  C CA  . TYR   A 1 126 ? -22.81755 -13.83873 -2.03434  1.000 9.96998  ? 126 TYR   A CA  1 
ATOM   969  C C   . TYR   A 1 126 ? -21.52619 -14.03447 -1.25785  1.000 10.71077 ? 126 TYR   A C   1 
ATOM   970  O O   . TYR   A 1 126 ? -20.53217 -13.32259 -1.46050  1.000 9.33641  ? 126 TYR   A O   1 
ATOM   971  C CB  . TYR   A 1 126 ? -22.94341 -14.88741 -3.15625  1.000 13.69034 ? 126 TYR   A CB  1 
ATOM   972  C CG  . TYR   A 1 126 ? -21.91933 -14.78313 -4.25288  1.000 10.11032 ? 126 TYR   A CG  1 
ATOM   973  C CD1 . TYR   A 1 126 ? -20.76968 -15.53890 -4.22286  1.000 17.40665 ? 126 TYR   A CD1 1 
ATOM   974  C CD2 . TYR   A 1 126 ? -22.10457 -13.91454 -5.32691  1.000 17.63646 ? 126 TYR   A CD2 1 
ATOM   975  C CE1 . TYR   A 1 126 ? -19.80969 -15.44865 -5.22910  1.000 16.41066 ? 126 TYR   A CE1 1 
ATOM   976  C CE2 . TYR   A 1 126 ? -21.16424 -13.81696 -6.33509  1.000 18.32954 ? 126 TYR   A CE2 1 
ATOM   977  C CZ  . TYR   A 1 126 ? -20.01284 -14.59396 -6.28162  1.000 19.74860 ? 126 TYR   A CZ  1 
ATOM   978  O OH  . TYR   A 1 126 ? -19.06297 -14.51142 -7.28469  1.000 17.16527 ? 126 TYR   A OH  1 
ATOM   979  N N   . GLN   A 1 127 ? -21.55914 -15.03703 -0.37834  1.000 12.11785 ? 127 GLN   A N   1 
ATOM   980  C CA  . GLN   A 1 127 ? -20.47209 -15.36685 0.53530   1.000 12.97611 ? 127 GLN   A CA  1 
ATOM   981  C C   . GLN   A 1 127 ? -19.55970 -16.39708 -0.12494  1.000 10.61967 ? 127 GLN   A C   1 
ATOM   982  O O   . GLN   A 1 127 ? -20.02038 -17.22549 -0.91714  1.000 16.51273 ? 127 GLN   A O   1 
ATOM   983  C CB  . GLN   A 1 127 ? -21.06504 -15.89583 1.85798   1.000 8.37579  ? 127 GLN   A CB  1 
ATOM   984  C CG  . GLN   A 1 127 ? -20.11605 -16.01584 3.03329   1.000 9.10522  ? 127 GLN   A CG  1 
ATOM   985  C CD  . GLN   A 1 127 ? -19.74987 -14.67434 3.64197   1.000 8.12604  ? 127 GLN   A CD  1 
ATOM   986  O OE1 . GLN   A 1 127 ? -20.04519 -13.62569 3.06980   1.000 9.87182  ? 127 GLN   A OE1 1 
ATOM   987  N NE2 . GLN   A 1 127 ? -19.11089 -14.70000 4.81680   1.000 7.42957  ? 127 GLN   A NE2 1 
ATOM   988  N N   . CYS   A 1 128 ? -18.25658 -16.31190 0.17075   1.000 8.47507  ? 128 CYS   A N   1 
ATOM   989  C CA  . CYS   A 1 128 ? -17.22536 -17.19669 -0.40049  1.000 11.01029 ? 128 CYS   A CA  1 
ATOM   990  C C   . CYS   A 1 128 ? -16.19157 -17.58164 0.64106   1.000 12.47930 ? 128 CYS   A C   1 
ATOM   991  O O   . CYS   A 1 128 ? -16.00885 -16.89847 1.65308   1.000 8.00837  ? 128 CYS   A O   1 
ATOM   992  C CB  . CYS   A 1 128 ? -16.40292 -16.56542 -1.55659  1.000 9.80169  ? 128 CYS   A CB  1 
ATOM   993  S SG  . CYS   A 1 128 ? -17.14029 -16.53766 -3.17206  1.000 25.73646 ? 128 CYS   A SG  1 
ATOM   994  N N   . ALA   A 1 129 ? -15.46058 -18.65354 0.33725   1.000 7.23239  ? 129 ALA   A N   1 
ATOM   995  C CA  . ALA   A 1 129 ? -14.27690 -19.02549 1.08299   1.000 5.88775  ? 129 ALA   A CA  1 
ATOM   996  C C   . ALA   A 1 129 ? -13.06122 -18.99232 0.17480   1.000 7.75302  ? 129 ALA   A C   1 
ATOM   997  O O   . ALA   A 1 129 ? -13.14173 -19.26364 -1.03325  1.000 10.68716 ? 129 ALA   A O   1 
ATOM   998  C CB  . ALA   A 1 129 ? -14.43178 -20.42583 1.72206   1.000 8.31284  ? 129 ALA   A CB  1 
ATOM   999  N N   . MET   A 1 130 ? -11.91856 -18.65798 0.76067   1.000 8.20091  ? 130 MET   A N   1 
ATOM   1000 C CA  . MET   A 1 130 ? -10.65255 -18.84712 0.06849   1.000 6.73507  ? 130 MET   A CA  1 
ATOM   1001 C C   . MET   A 1 130 ? -10.24283 -20.30018 0.25249   1.000 10.78630 ? 130 MET   A C   1 
ATOM   1002 O O   . MET   A 1 130 ? -10.02009 -20.74600 1.38123   1.000 8.12289  ? 130 MET   A O   1 
ATOM   1003 C CB  . MET   A 1 130 ? -9.58922  -17.89088 0.60118   1.000 6.45002  ? 130 MET   A CB  1 
ATOM   1004 C CG  . MET   A 1 130 ? -8.19290  -18.14330 0.07378   1.000 10.84161 ? 130 MET   A CG  1 
ATOM   1005 S SD  . MET   A 1 130 ? -7.87927  -17.33618 -1.48854  1.000 13.06230 ? 130 MET   A SD  1 
ATOM   1006 C CE  . MET   A 1 130 ? -8.17438  -15.65117 -1.04537  1.000 5.81141  ? 130 MET   A CE  1 
ATOM   1007 N N   . ARG   A 1 131 ? -10.19222 -21.03928 -0.85296  1.000 7.47125  ? 131 ARG   A N   1 
ATOM   1008 C CA  . ARG   A 1 131 ? -9.86182  -22.45106 -0.80756  1.000 12.31431 ? 131 ARG   A CA  1 
ATOM   1009 C C   . ARG   A 1 131 ? -8.39905  -22.63578 -0.41147  1.000 8.70411  ? 131 ARG   A C   1 
ATOM   1010 O O   . ARG   A 1 131 ? -7.56591  -21.75511 -0.65162  1.000 12.47376 ? 131 ARG   A O   1 
ATOM   1011 C CB  . ARG   A 1 131 ? -10.12133 -23.11365 -2.16287  1.000 6.06663  ? 131 ARG   A CB  1 
ATOM   1012 C CG  . ARG   A 1 131 ? -11.55462 -23.05498 -2.65307  1.000 7.72980  ? 131 ARG   A CG  1 
ATOM   1013 C CD  . ARG   A 1 131 ? -12.58608 -23.49096 -1.60448  1.000 8.06035  ? 131 ARG   A CD  1 
ATOM   1014 N NE  . ARG   A 1 131 ? -12.25475 -24.78667 -1.01591  1.000 12.71909 ? 131 ARG   A NE  1 
ATOM   1015 C CZ  . ARG   A 1 131 ? -12.92784 -25.34824 -0.00517  1.000 13.29501 ? 131 ARG   A CZ  1 
ATOM   1016 N NH1 . ARG   A 1 131 ? -13.99798 -24.73200 0.50029   1.000 10.64161 ? 131 ARG   A NH1 1 
ATOM   1017 N NH2 . ARG   A 1 131 ? -12.53594 -26.52479 0.49637   1.000 6.05667  ? 131 ARG   A NH2 1 
ATOM   1018 N N   . PRO   A 1 132 ? -8.06539  -23.76571 0.21457   1.000 11.50185 ? 132 PRO   A N   1 
ATOM   1019 C CA  . PRO   A 1 132 ? -6.65020  -24.03632 0.52368   1.000 11.46240 ? 132 PRO   A CA  1 
ATOM   1020 C C   . PRO   A 1 132 ? -5.69686  -23.87938 -0.66463  1.000 15.25519 ? 132 PRO   A C   1 
ATOM   1021 O O   . PRO   A 1 132 ? -4.53758  -23.51084 -0.44636  1.000 11.13950 ? 132 PRO   A O   1 
ATOM   1022 C CB  . PRO   A 1 132 ? -6.69373  -25.47538 1.04438   1.000 12.73953 ? 132 PRO   A CB  1 
ATOM   1023 C CG  . PRO   A 1 132 ? -8.05413  -25.54483 1.74458   1.000 9.18855  ? 132 PRO   A CG  1 
ATOM   1024 C CD  . PRO   A 1 132 ? -8.97989  -24.71715 0.89823   1.000 10.30272 ? 132 PRO   A CD  1 
ATOM   1025 N N   . ASN   A 1 133 ? -6.14076  -24.11865 -1.90766  1.000 10.99260 ? 133 ASN   A N   1 
ATOM   1026 C CA  . ASN   A 1 133 ? -5.28728  -23.93601 -3.07823  1.000 8.25561  ? 133 ASN   A CA  1 
ATOM   1027 C C   . ASN   A 1 133 ? -5.35118  -22.52540 -3.65422  1.000 7.42480  ? 133 ASN   A C   1 
ATOM   1028 O O   . ASN   A 1 133 ? -4.90063  -22.31734 -4.78618  1.000 8.24272  ? 133 ASN   A O   1 
ATOM   1029 C CB  . ASN   A 1 133 ? -5.63097  -24.95680 -4.17781  1.000 8.72274  ? 133 ASN   A CB  1 
ATOM   1030 C CG  . ASN   A 1 133 ? -7.05548  -24.79914 -4.73678  1.000 10.87806 ? 133 ASN   A CG  1 
ATOM   1031 O OD1 . ASN   A 1 133 ? -7.72294  -23.79264 -4.51869  1.000 10.76687 ? 133 ASN   A OD1 1 
ATOM   1032 N ND2 . ASN   A 1 133 ? -7.51848  -25.82013 -5.46180  1.000 11.15126 ? 133 ASN   A ND2 1 
ATOM   1033 N N   . PHE   A 1 134 ? -5.93662  -21.57420 -2.92216  1.000 8.13966  ? 134 PHE   A N   1 
ATOM   1034 C CA  . PHE   A 1 134 ? -5.96233  -20.14491 -3.24807  1.000 9.52006  ? 134 PHE   A CA  1 
ATOM   1035 C C   . PHE   A 1 134 ? -6.89790  -19.81255 -4.39201  1.000 9.08294  ? 134 PHE   A C   1 
ATOM   1036 O O   . PHE   A 1 134 ? -6.75178  -18.76015 -5.02930  1.000 10.71232 ? 134 PHE   A O   1 
ATOM   1037 C CB  . PHE   A 1 134 ? -4.57413  -19.58203 -3.58840  1.000 8.57064  ? 134 PHE   A CB  1 
ATOM   1038 C CG  . PHE   A 1 134 ? -3.64367  -19.50453 -2.42805  1.000 7.96325  ? 134 PHE   A CG  1 
ATOM   1039 C CD1 . PHE   A 1 134 ? -3.69807  -18.44313 -1.54417  1.000 6.73772  ? 134 PHE   A CD1 1 
ATOM   1040 C CD2 . PHE   A 1 134 ? -2.69240  -20.49074 -2.23105  1.000 14.18510 ? 134 PHE   A CD2 1 
ATOM   1041 C CE1 . PHE   A 1 134 ? -2.83106  -18.37224 -0.46630  1.000 13.19682 ? 134 PHE   A CE1 1 
ATOM   1042 C CE2 . PHE   A 1 134 ? -1.80869  -20.43233 -1.15234  1.000 12.52659 ? 134 PHE   A CE2 1 
ATOM   1043 C CZ  . PHE   A 1 134 ? -1.88188  -19.36807 -0.26134  1.000 11.84705 ? 134 PHE   A CZ  1 
ATOM   1044 N N   . THR   A 1 135 ? -7.83191  -20.69335 -4.69352  1.000 11.14238 ? 135 THR   A N   1 
ATOM   1045 C CA  . THR   A 1 135 ? -8.88788  -20.38117 -5.63725  1.000 12.80266 ? 135 THR   A CA  1 
ATOM   1046 C C   . THR   A 1 135 ? -10.14186 -20.06581 -4.84017  1.000 12.47340 ? 135 THR   A C   1 
ATOM   1047 O O   . THR   A 1 135 ? -10.20776 -20.26697 -3.61909  1.000 10.41948 ? 135 THR   A O   1 
ATOM   1048 C CB  . THR   A 1 135 ? -9.13283  -21.54229 -6.61837  1.000 13.72976 ? 135 THR   A CB  1 
ATOM   1049 O OG1 . THR   A 1 135 ? -9.63226  -22.68178 -5.90956  1.000 6.90267  ? 135 THR   A OG1 1 
ATOM   1050 C CG2 . THR   A 1 135 ? -7.81387  -21.94254 -7.38093  1.000 8.31767  ? 135 THR   A CG2 1 
ATOM   1051 N N   . ILE   A 1 136 ? -11.12416 -19.52314 -5.53595  1.000 9.18343  ? 136 ILE   A N   1 
ATOM   1052 C CA  . ILE   A 1 136 ? -12.44908 -19.31275 -4.98084  1.000 15.71138 ? 136 ILE   A CA  1 
ATOM   1053 C C   . ILE   A 1 136 ? -13.45300 -19.90397 -5.96473  1.000 13.81661 ? 136 ILE   A C   1 
ATOM   1054 O O   . ILE   A 1 136 ? -13.28515 -19.78952 -7.18296  1.000 9.33224  ? 136 ILE   A O   1 
ATOM   1055 C CB  . ILE   A 1 136 ? -12.73566 -17.82093 -4.69540  1.000 15.83498 ? 136 ILE   A CB  1 
ATOM   1056 C CG1 . ILE   A 1 136 ? -12.65723 -17.01510 -5.98662  1.000 15.05146 ? 136 ILE   A CG1 1 
ATOM   1057 C CG2 . ILE   A 1 136 ? -11.72786 -17.24162 -3.61522  1.000 9.80241  ? 136 ILE   A CG2 1 
ATOM   1058 C CD1 . ILE   A 1 136 ? -13.49630 -15.78850 -5.97314  1.000 13.11771 ? 136 ILE   A CD1 1 
ATOM   1059 N N   . LYS   A 1 137 ? -14.45852 -20.59771 -5.42845  1.000 9.08716  ? 137 LYS   A N   1 
ATOM   1060 C CA  . LYS   A 1 137 ? -15.55551 -21.16381 -6.21036  1.000 12.49265 ? 137 LYS   A CA  1 
ATOM   1061 C C   . LYS   A 1 137 ? -16.67153 -20.12527 -6.24816  1.000 10.32988 ? 137 LYS   A C   1 
ATOM   1062 O O   . LYS   A 1 137 ? -17.58412 -20.12627 -5.42152  1.000 9.68087  ? 137 LYS   A O   1 
ATOM   1063 C CB  . LYS   A 1 137 ? -16.02436 -22.47606 -5.59611  1.000 17.03831 ? 137 LYS   A CB  1 
ATOM   1064 C CG  . LYS   A 1 137 ? -14.91469 -23.45895 -5.30907  1.000 17.90278 ? 137 LYS   A CG  1 
ATOM   1065 C CD  . LYS   A 1 137 ? -15.46779 -24.79701 -4.88240  1.000 20.77497 ? 137 LYS   A CD  1 
ATOM   1066 C CE  . LYS   A 1 137 ? -14.39862 -25.87758 -4.91910  1.000 24.35349 ? 137 LYS   A CE  1 
ATOM   1067 N NZ  . LYS   A 1 137 ? -14.14921 -26.41846 -6.28018  1.000 27.45850 ? 137 LYS   A NZ  1 
ATOM   1068 N N   . GLY   A 1 138 ? -16.59735 -19.22515 -7.21967  1.000 8.27365  ? 138 GLY   A N   1 
ATOM   1069 C CA  . GLY   A 1 138 ? -17.49820 -18.10623 -7.30884  1.000 13.98830 ? 138 GLY   A CA  1 
ATOM   1070 C C   . GLY   A 1 138 ? -18.59805 -18.29196 -8.33597  1.000 20.86298 ? 138 GLY   A C   1 
ATOM   1071 O O   . GLY   A 1 138 ? -18.91511 -19.40735 -8.76908  1.000 24.74611 ? 138 GLY   A O   1 
ATOM   1072 N N   . SER   A 1 139 ? -19.22754 -17.17588 -8.68837  1.000 14.84996 ? 139 SER   A N   1 
ATOM   1073 C CA  . SER   A 1 139 ? -20.14147 -17.10122 -9.82638  1.000 20.55132 ? 139 SER   A CA  1 
ATOM   1074 C C   . SER   A 1 139 ? -19.83457 -15.79419 -10.54449 1.000 19.55097 ? 139 SER   A C   1 
ATOM   1075 O O   . SER   A 1 139 ? -20.23575 -14.71964 -10.07819 1.000 13.92356 ? 139 SER   A O   1 
ATOM   1076 C CB  . SER   A 1 139 ? -21.59656 -17.15666 -9.40223  1.000 17.73013 ? 139 SER   A CB  1 
ATOM   1077 O OG  . SER   A 1 139 ? -22.39906 -16.67095 -10.45493 1.000 17.90828 ? 139 SER   A OG  1 
ATOM   1078 N N   . PHE   A 1 140 ? -19.14452 -15.90503 -11.68236 1.000 21.11332 ? 140 PHE   A N   1 
ATOM   1079 C CA  . PHE   A 1 140 ? -18.63321 -14.77649 -12.45255 1.000 23.75450 ? 140 PHE   A CA  1 
ATOM   1080 C C   . PHE   A 1 140 ? -18.78968 -15.07661 -13.93710 1.000 29.16978 ? 140 PHE   A C   1 
ATOM   1081 O O   . PHE   A 1 140 ? -18.31343 -16.11488 -14.40581 1.000 31.39173 ? 140 PHE   A O   1 
ATOM   1082 C CB  . PHE   A 1 140 ? -17.14525 -14.52591 -12.15701 1.000 15.57427 ? 140 PHE   A CB  1 
ATOM   1083 C CG  . PHE   A 1 140 ? -16.86703 -13.92851 -10.78498 1.000 19.44367 ? 140 PHE   A CG  1 
ATOM   1084 C CD1 . PHE   A 1 140 ? -17.36733 -12.69491 -10.43128 1.000 17.35884 ? 140 PHE   A CD1 1 
ATOM   1085 C CD2 . PHE   A 1 140 ? -16.06354 -14.59694 -9.87278  1.000 19.10232 ? 140 PHE   A CD2 1 
ATOM   1086 C CE1 . PHE   A 1 140 ? -17.09262 -12.15576 -9.19135  1.000 18.85094 ? 140 PHE   A CE1 1 
ATOM   1087 C CE2 . PHE   A 1 140 ? -15.78282 -14.05625 -8.62863  1.000 16.10485 ? 140 PHE   A CE2 1 
ATOM   1088 C CZ  . PHE   A 1 140 ? -16.28951 -12.83427 -8.29462  1.000 15.47627 ? 140 PHE   A CZ  1 
ATOM   1089 N N   . LEU   A 1 141 ? -19.42443 -14.17156 -14.68151 1.000 23.73074 ? 141 LEU   A N   1 
ATOM   1090 C CA  . LEU   A 1 141 ? -19.45612 -14.27468 -16.13395 1.000 28.02850 ? 141 LEU   A CA  1 
ATOM   1091 C C   . LEU   A 1 141 ? -18.50544 -13.25333 -16.74908 1.000 31.54250 ? 141 LEU   A C   1 
ATOM   1092 O O   . LEU   A 1 141 ? -17.90271 -12.42886 -16.05758 1.000 27.55486 ? 141 LEU   A O   1 
ATOM   1093 C CB  . LEU   A 1 141 ? -20.87293 -14.07448 -16.67269 1.000 26.30699 ? 141 LEU   A CB  1 
ATOM   1094 C CG  . LEU   A 1 141 ? -21.97193 -14.90985 -16.03530 1.000 22.96902 ? 141 LEU   A CG  1 
ATOM   1095 C CD1 . LEU   A 1 141 ? -23.28898 -14.21570 -16.27253 1.000 24.58063 ? 141 LEU   A CD1 1 
ATOM   1096 C CD2 . LEU   A 1 141 ? -21.95739 -16.28921 -16.65055 1.000 27.55045 ? 141 LEU   A CD2 1 
ATOM   1097 N N   . ASN   A 1 142 ? -18.39067 -13.30301 -18.07492 1.000 32.19391 ? 142 ASN   A N   1 
ATOM   1098 C CA  . ASN   A 1 142 ? -17.57598 -12.32657 -18.78076 1.000 30.74165 ? 142 ASN   A CA  1 
ATOM   1099 C C   . ASN   A 1 142 ? -18.04468 -10.91060 -18.46496 1.000 33.28339 ? 142 ASN   A C   1 
ATOM   1100 O O   . ASN   A 1 142 ? -19.24915 -10.62243 -18.44527 1.000 32.16757 ? 142 ASN   A O   1 
ATOM   1101 C CB  . ASN   A 1 142 ? -17.61535 -12.59581 -20.28177 1.000 32.18644 ? 142 ASN   A CB  1 
ATOM   1102 C CG  . ASN   A 1 142 ? -16.61592 -13.65154 -20.69046 1.000 38.16881 ? 142 ASN   A CG  1 
ATOM   1103 O OD1 . ASN   A 1 142 ? -15.40985 -13.39467 -20.74797 1.000 44.97846 ? 142 ASN   A OD1 1 
ATOM   1104 N ND2 . ASN   A 1 142 ? -17.10471 -14.85346 -20.96007 1.000 39.22738 ? 142 ASN   A ND2 1 
ATOM   1105 N N   . GLY   A 1 143 ? -17.07917 -10.04160 -18.16815 1.000 25.46589 ? 143 GLY   A N   1 
ATOM   1106 C CA  . GLY   A 1 143 ? -17.34709 -8.68042  -17.77022 1.000 22.30451 ? 143 GLY   A CA  1 
ATOM   1107 C C   . GLY   A 1 143 ? -17.30831 -8.44059  -16.27957 1.000 22.52811 ? 143 GLY   A C   1 
ATOM   1108 O O   . GLY   A 1 143 ? -17.40922 -7.28782  -15.85430 1.000 20.73584 ? 143 GLY   A O   1 
ATOM   1109 N N   . SER   A 1 144 ? -17.17368 -9.48594  -15.47346 1.000 23.84955 ? 144 SER   A N   1 
ATOM   1110 C CA  . SER   A 1 144 ? -17.12330 -9.31926  -14.02243 1.000 25.02941 ? 144 SER   A CA  1 
ATOM   1111 C C   . SER   A 1 144 ? -15.73211 -8.97782  -13.49596 1.000 20.71234 ? 144 SER   A C   1 
ATOM   1112 O O   . SER   A 1 144 ? -15.55978 -8.88275  -12.27358 1.000 19.13643 ? 144 SER   A O   1 
ATOM   1113 C CB  . SER   A 1 144 ? -17.62009 -10.59128 -13.33809 1.000 19.66414 ? 144 SER   A CB  1 
ATOM   1114 O OG  . SER   A 1 144 ? -16.70753 -11.64615 -13.55240 1.000 20.35135 ? 144 SER   A OG  1 
ATOM   1115 N N   . CYS   A 1 145 ? -14.73738 -8.81758  -14.36984 1.000 22.97801 ? 145 CYS   A N   1 
ATOM   1116 C CA  . CYS   A 1 145 ? -13.38507 -8.51780  -13.90706 1.000 19.52917 ? 145 CYS   A CA  1 
ATOM   1117 C C   . CYS   A 1 145 ? -13.36891 -7.19888  -13.13728 1.000 15.64653 ? 145 CYS   A C   1 
ATOM   1118 O O   . CYS   A 1 145 ? -14.02927 -6.22943  -13.51554 1.000 16.02227 ? 145 CYS   A O   1 
ATOM   1119 C CB  . CYS   A 1 145 ? -12.41741 -8.46831  -15.09046 1.000 20.05584 ? 145 CYS   A CB  1 
ATOM   1120 S SG  . CYS   A 1 145 ? -11.95549 -10.09855 -15.71605 1.000 32.70925 ? 145 CYS   A SG  1 
ATOM   1121 N N   . GLY   A 1 146 ? -12.64684 -7.18419  -12.01532 1.000 13.50551 ? 146 GLY   A N   1 
ATOM   1122 C CA  . GLY   A 1 146 ? -12.60883 -6.03719  -11.14549 1.000 13.60116 ? 146 GLY   A CA  1 
ATOM   1123 C C   . GLY   A 1 146 ? -13.59465 -6.06056  -9.99458  1.000 15.82359 ? 146 GLY   A C   1 
ATOM   1124 O O   . GLY   A 1 146 ? -13.51439 -5.17245  -9.11764  1.000 7.51345  ? 146 GLY   A O   1 
ATOM   1125 N N   . SER   A 1 147 ? -14.54072 -7.01644  -9.98682  1.000 16.23984 ? 147 SER   A N   1 
ATOM   1126 C CA  . SER   A 1 147 ? -15.41698 -7.19630  -8.83353  1.000 9.30158  ? 147 SER   A CA  1 
ATOM   1127 C C   . SER   A 1 147 ? -14.57485 -7.55873  -7.62173  1.000 6.77820  ? 147 SER   A C   1 
ATOM   1128 O O   . SER   A 1 147 ? -13.59526 -8.28798  -7.75127  1.000 6.94027  ? 147 SER   A O   1 
ATOM   1129 C CB  . SER   A 1 147 ? -16.43907 -8.30054  -9.10236  1.000 11.89817 ? 147 SER   A CB  1 
ATOM   1130 O OG  . SER   A 1 147 ? -17.04568 -8.11018  -10.36639 1.000 20.23659 ? 147 SER   A OG  1 
ATOM   1131 N N   . VAL   A 1 148 ? -14.94984 -7.03563  -6.44430  1.000 7.54681  ? 148 VAL   A N   1 
ATOM   1132 C CA  . VAL   A 1 148 ? -14.14235 -7.15281  -5.22094  1.000 6.98242  ? 148 VAL   A CA  1 
ATOM   1133 C C   . VAL   A 1 148 ? -14.81778 -8.02506  -4.16401  1.000 5.04912  ? 148 VAL   A C   1 
ATOM   1134 O O   . VAL   A 1 148 ? -16.04188 -8.17677  -4.11818  1.000 6.04276  ? 148 VAL   A O   1 
ATOM   1135 C CB  . VAL   A 1 148 ? -13.79846 -5.78076  -4.59068  1.000 5.69781  ? 148 VAL   A CB  1 
ATOM   1136 C CG1 . VAL   A 1 148 ? -12.82774 -4.98824  -5.44206  1.000 7.82543  ? 148 VAL   A CG1 1 
ATOM   1137 C CG2 . VAL   A 1 148 ? -15.08088 -5.00511  -4.40061  1.000 10.13481 ? 148 VAL   A CG2 1 
ATOM   1138 N N   . GLY   A 1 149 ? -13.98172 -8.55893  -3.26885  1.000 2.47297  ? 149 GLY   A N   1 
ATOM   1139 C CA  . GLY   A 1 149 ? -14.42797 -9.26620  -2.07801  1.000 6.77478  ? 149 GLY   A CA  1 
ATOM   1140 C C   . GLY   A 1 149 ? -14.02668 -8.53197  -0.80731  1.000 6.12329  ? 149 GLY   A C   1 
ATOM   1141 O O   . GLY   A 1 149 ? -12.99095 -7.87103  -0.76120  1.000 5.42707  ? 149 GLY   A O   1 
ATOM   1142 N N   . PHE   A 1 150 ? -14.83558 -8.66473  0.24773   1.000 4.52567  ? 150 PHE   A N   1 
ATOM   1143 C CA  . PHE   A 1 150 ? -14.66469 -7.76554  1.37617   1.000 4.39799  ? 150 PHE   A CA  1 
ATOM   1144 C C   . PHE   A 1 150 ? -15.24995 -8.36379  2.65128   1.000 7.60389  ? 150 PHE   A C   1 
ATOM   1145 O O   . PHE   A 1 150 ? -16.17942 -9.17618  2.61356   1.000 6.41380  ? 150 PHE   A O   1 
ATOM   1146 C CB  . PHE   A 1 150 ? -15.32963 -6.40875  1.08890   1.000 5.50884  ? 150 PHE   A CB  1 
ATOM   1147 C CG  . PHE   A 1 150 ? -16.82135 -6.47788  1.05989   1.000 4.65387  ? 150 PHE   A CG  1 
ATOM   1148 C CD1 . PHE   A 1 150 ? -17.47509 -6.96607  -0.05823  1.000 7.56898  ? 150 PHE   A CD1 1 
ATOM   1149 C CD2 . PHE   A 1 150 ? -17.57560 -6.08067  2.14841   1.000 5.74092  ? 150 PHE   A CD2 1 
ATOM   1150 C CE1 . PHE   A 1 150 ? -18.86557 -7.05181  -0.09427  1.000 6.89608  ? 150 PHE   A CE1 1 
ATOM   1151 C CE2 . PHE   A 1 150 ? -18.95138 -6.16885  2.12552   1.000 5.27279  ? 150 PHE   A CE2 1 
ATOM   1152 C CZ  . PHE   A 1 150 ? -19.60259 -6.66225  0.98969   1.000 3.87392  ? 150 PHE   A CZ  1 
ATOM   1153 N N   . ASN   A 1 151 ? -14.72210 -7.90554  3.78968   1.000 13.08233 ? 151 ASN   A N   1 
ATOM   1154 C CA  . ASN   A 1 151 ? -15.32260 -8.12046  5.10508   1.000 11.54771 ? 151 ASN   A CA  1 
ATOM   1155 C C   . ASN   A 1 151 ? -15.59353 -6.77334  5.78187   1.000 9.05304  ? 151 ASN   A C   1 
ATOM   1156 O O   . ASN   A 1 151 ? -14.98142 -5.75249  5.46244   1.000 8.53104  ? 151 ASN   A O   1 
ATOM   1157 C CB  . ASN   A 1 151 ? -14.43587 -9.01081  5.99837   1.000 9.94770  ? 151 ASN   A CB  1 
ATOM   1158 C CG  . ASN   A 1 151 ? -14.54729 -10.51057 5.65533   1.000 7.12648  ? 151 ASN   A CG  1 
ATOM   1159 O OD1 . ASN   A 1 151 ? -15.54817 -11.17409 5.99720   1.000 8.94833  ? 151 ASN   A OD1 1 
ATOM   1160 N ND2 . ASN   A 1 151 ? -13.52569 -11.05190 5.01624   1.000 6.01170  ? 151 ASN   A ND2 1 
ATOM   1161 N N   . ILE   A 1 152 ? -16.54406 -6.77619  6.71899   1.000 10.75917 ? 152 ILE   A N   1 
ATOM   1162 C CA  . ILE   A 1 152 ? -17.06327 -5.56111  7.34343   1.000 10.24772 ? 152 ILE   A CA  1 
ATOM   1163 C C   . ILE   A 1 152 ? -16.92287 -5.69942  8.85114   1.000 16.25364 ? 152 ILE   A C   1 
ATOM   1164 O O   . ILE   A 1 152 ? -17.53601 -6.58482  9.45242   1.000 11.56235 ? 152 ILE   A O   1 
ATOM   1165 C CB  . ILE   A 1 152 ? -18.53131 -5.30147  6.97540   1.000 9.26949  ? 152 ILE   A CB  1 
ATOM   1166 C CG1 . ILE   A 1 152 ? -18.67314 -5.31402  5.47254   1.000 9.94120  ? 152 ILE   A CG1 1 
ATOM   1167 C CG2 . ILE   A 1 152 ? -19.00760 -3.94718  7.53020   1.000 12.01389 ? 152 ILE   A CG2 1 
ATOM   1168 C CD1 . ILE   A 1 152 ? -18.08392 -4.11354  4.85232   1.000 9.75523  ? 152 ILE   A CD1 1 
ATOM   1169 N N   . ASP   A 1 153 ? -16.11907 -4.83215  9.45451   1.000 22.88485 ? 153 ASP   A N   1 
ATOM   1170 C CA  . ASP   A 1 153 ? -15.88212 -4.81512  10.89894  1.000 35.81005 ? 153 ASP   A CA  1 
ATOM   1171 C C   . ASP   A 1 153 ? -16.50743 -3.52778  11.42042  1.000 38.59214 ? 153 ASP   A C   1 
ATOM   1172 O O   . ASP   A 1 153 ? -15.93482 -2.43603  11.28908  1.000 34.35083 ? 153 ASP   A O   1 
ATOM   1173 C CB  . ASP   A 1 153 ? -14.39522 -4.90837  11.22648  1.000 34.25240 ? 153 ASP   A CB  1 
ATOM   1174 C CG  . ASP   A 1 153 ? -14.12186 -5.33203  12.66181  1.000 44.27184 ? 153 ASP   A CG  1 
ATOM   1175 O OD1 . ASP   A 1 153 ? -14.97725 -5.09999  13.54239  1.000 36.63502 ? 153 ASP   A OD1 1 
ATOM   1176 O OD2 . ASP   A 1 153 ? -13.03222 -5.89851  12.90133  1.000 51.33496 ? 153 ASP   A OD2 1 
ATOM   1177 N N   . TYR   A 1 154 ? -17.69173 -3.69897  12.00695  1.000 42.73587 ? 154 TYR   A N   1 
ATOM   1178 C CA  . TYR   A 1 154 ? -18.62603 -2.67433  12.44894  1.000 42.49342 ? 154 TYR   A CA  1 
ATOM   1179 C C   . TYR   A 1 154 ? -18.74742 -1.61816  11.33901  1.000 33.60036 ? 154 TYR   A C   1 
ATOM   1180 O O   . TYR   A 1 154 ? -19.49491 -1.84482  10.38320  1.000 41.59267 ? 154 TYR   A O   1 
ATOM   1181 C CB  . TYR   A 1 154 ? -18.20633 -2.10273  13.80737  1.000 46.72380 ? 154 TYR   A CB  1 
ATOM   1182 C CG  . TYR   A 1 154 ? -19.36381 -1.38727  14.47243  1.000 59.16999 ? 154 TYR   A CG  1 
ATOM   1183 C CD1 . TYR   A 1 154 ? -20.45934 -2.12326  14.92147  1.000 57.42169 ? 154 TYR   A CD1 1 
ATOM   1184 C CD2 . TYR   A 1 154 ? -19.35313 -0.01765  14.71623  1.000 61.23977 ? 154 TYR   A CD2 1 
ATOM   1185 C CE1 . TYR   A 1 154 ? -21.53132 -1.51685  15.54210  1.000 58.21566 ? 154 TYR   A CE1 1 
ATOM   1186 C CE2 . TYR   A 1 154 ? -20.43286 0.60427   15.35293  1.000 66.86505 ? 154 TYR   A CE2 1 
ATOM   1187 C CZ  . TYR   A 1 154 ? -21.51986 -0.16361  15.76176  1.000 64.50105 ? 154 TYR   A CZ  1 
ATOM   1188 O OH  . TYR   A 1 154 ? -22.59578 0.42442   16.39241  1.000 53.27052 ? 154 TYR   A OH  1 
ATOM   1189 N N   . ASP   A 1 155 ? -18.01163 -0.49730  11.36966  1.000 34.24314 ? 155 ASP   A N   1 
ATOM   1190 C CA  . ASP   A 1 155 ? -18.13071 0.44925   10.25762  1.000 31.98377 ? 155 ASP   A CA  1 
ATOM   1191 C C   . ASP   A 1 155 ? -17.01603 0.35534   9.21695   1.000 25.86157 ? 155 ASP   A C   1 
ATOM   1192 O O   . ASP   A 1 155 ? -16.98239 1.21455   8.33635   1.000 19.53913 ? 155 ASP   A O   1 
ATOM   1193 C CB  . ASP   A 1 155 ? -18.13687 1.89953   10.73033  1.000 36.73861 ? 155 ASP   A CB  1 
ATOM   1194 C CG  . ASP   A 1 155 ? -16.83716 2.26419   11.40922  1.000 40.96128 ? 155 ASP   A CG  1 
ATOM   1195 O OD1 . ASP   A 1 155 ? -16.05562 1.33575   11.71732  1.000 42.98124 ? 155 ASP   A OD1 1 
ATOM   1196 O OD2 . ASP   A 1 155 ? -16.52402 3.48602   11.44097  1.000 44.88458 ? 155 ASP   A OD2 1 
ATOM   1197 N N   . CYS   A 1 156 ? -16.08515 -0.60146  9.30318   1.000 27.19001 ? 156 CYS   A N   1 
ATOM   1198 C CA  . CYS   A 1 156 ? -14.88450 -0.57797  8.47076   1.000 13.53499 ? 156 CYS   A CA  1 
ATOM   1199 C C   . CYS   A 1 156 ? -14.90443 -1.70945  7.45317   1.000 13.39968 ? 156 CYS   A C   1 
ATOM   1200 O O   . CYS   A 1 156 ? -15.09329 -2.87722  7.82058   1.000 10.22847 ? 156 CYS   A O   1 
ATOM   1201 C CB  . CYS   A 1 156 ? -13.62854 -0.66328  9.33608   1.000 17.85016 ? 156 CYS   A CB  1 
ATOM   1202 S SG  . CYS   A 1 156 ? -12.08312 -0.48233  8.36719   1.000 16.83456 ? 156 CYS   A SG  1 
ATOM   1203 N N   . VAL   A 1 157 ? -14.66418 -1.35694  6.18721   1.000 15.08991 ? 157 VAL   A N   1 
ATOM   1204 C CA  . VAL   A 1 157 ? -14.64391 -2.31145  5.07864   1.000 13.34930 ? 157 VAL   A CA  1 
ATOM   1205 C C   . VAL   A 1 157 ? -13.21305 -2.79371  4.84059   1.000 11.50927 ? 157 VAL   A C   1 
ATOM   1206 O O   . VAL   A 1 157 ? -12.37897 -2.04878  4.32573   1.000 10.05726 ? 157 VAL   A O   1 
ATOM   1207 C CB  . VAL   A 1 157 ? -15.19907 -1.69063  3.79317   1.000 10.87689 ? 157 VAL   A CB  1 
ATOM   1208 C CG1 . VAL   A 1 157 ? -15.25453 -2.75446  2.67697   1.000 8.93284  ? 157 VAL   A CG1 1 
ATOM   1209 C CG2 . VAL   A 1 157 ? -16.54554 -1.01549  4.04452   1.000 14.17017 ? 157 VAL   A CG2 1 
ATOM   1210 N N   . SER   A 1 158 ? -12.94897 -4.06019  5.13410   1.000 9.10075  ? 158 SER   A N   1 
ATOM   1211 C CA  . SER   A 1 158 ? -11.66863 -4.68981  4.80731   1.000 9.18588  ? 158 SER   A CA  1 
ATOM   1212 C C   . SER   A 1 158 ? -11.76374 -5.31071  3.41217   1.000 8.10258  ? 158 SER   A C   1 
ATOM   1213 O O   . SER   A 1 158 ? -12.29746 -6.41400  3.23595   1.000 6.44254  ? 158 SER   A O   1 
ATOM   1214 C CB  . SER   A 1 158 ? -11.32121 -5.74394  5.85051   1.000 9.82877  ? 158 SER   A CB  1 
ATOM   1215 O OG  . SER   A 1 158 ? -10.98526 -5.13480  7.07769   1.000 14.69357 ? 158 SER   A OG  1 
ATOM   1216 N N   . PHE   A 1 159 ? -11.27440 -4.60095  2.40467   1.000 6.79277  ? 159 PHE   A N   1 
ATOM   1217 C CA  . PHE   A 1 159 ? -11.23827 -5.18424  1.07303   1.000 5.03212  ? 159 PHE   A CA  1 
ATOM   1218 C C   . PHE   A 1 159 ? -10.14170 -6.24435  1.03179   1.000 5.18816  ? 159 PHE   A C   1 
ATOM   1219 O O   . PHE   A 1 159 ? -9.01157  -5.99990  1.46858   1.000 6.77179  ? 159 PHE   A O   1 
ATOM   1220 C CB  . PHE   A 1 159 ? -10.98678 -4.10908  0.01626   1.000 6.00114  ? 159 PHE   A CB  1 
ATOM   1221 C CG  . PHE   A 1 159 ? -12.06979 -3.09228  -0.10222  1.000 7.36618  ? 159 PHE   A CG  1 
ATOM   1222 C CD1 . PHE   A 1 159 ? -13.21003 -3.35376  -0.86330  1.000 7.55622  ? 159 PHE   A CD1 1 
ATOM   1223 C CD2 . PHE   A 1 159 ? -11.93828 -1.85182  0.49386   1.000 8.44212  ? 159 PHE   A CD2 1 
ATOM   1224 C CE1 . PHE   A 1 159 ? -14.19867 -2.41583  -1.00275  1.000 4.50523  ? 159 PHE   A CE1 1 
ATOM   1225 C CE2 . PHE   A 1 159 ? -12.93937 -0.89403  0.35299   1.000 8.70654  ? 159 PHE   A CE2 1 
ATOM   1226 C CZ  . PHE   A 1 159 ? -14.06486 -1.18124  -0.40194  1.000 11.52960 ? 159 PHE   A CZ  1 
ATOM   1227 N N   . CYS   A 1 160 ? -10.47607 -7.43518  0.53770   1.000 6.60094  ? 160 CYS   A N   1 
ATOM   1228 C CA  . CYS   A 1 160 ? -9.49353  -8.50131  0.48305   1.000 9.52483  ? 160 CYS   A CA  1 
ATOM   1229 C C   . CYS   A 1 160 ? -9.26548  -9.13639  -0.88692  1.000 5.16059  ? 160 CYS   A C   1 
ATOM   1230 O O   . CYS   A 1 160 ? -8.26464  -9.84115  -1.03107  1.000 6.21144  ? 160 CYS   A O   1 
ATOM   1231 C CB  . CYS   A 1 160 ? -9.85107  -9.61000  1.50114   1.000 5.73609  ? 160 CYS   A CB  1 
ATOM   1232 S SG  . CYS   A 1 160 ? -11.41814 -10.54419 1.18259   1.000 8.80324  ? 160 CYS   A SG  1 
ATOM   1233 N N   . TYR   A 1 161 ? -10.14599 -8.94892  -1.88070  1.000 5.87895  ? 161 TYR   A N   1 
ATOM   1234 C CA  . TYR   A 1 161 ? -10.05041 -9.73285  -3.11424  1.000 7.83778  ? 161 TYR   A CA  1 
ATOM   1235 C C   . TYR   A 1 161 ? -10.51403 -8.91363  -4.32154  1.000 7.46862  ? 161 TYR   A C   1 
ATOM   1236 O O   . TYR   A 1 161 ? -11.52908 -8.21546  -4.24062  1.000 7.45434  ? 161 TYR   A O   1 
ATOM   1237 C CB  . TYR   A 1 161 ? -10.89013 -11.02817 -3.00379  1.000 7.95820  ? 161 TYR   A CB  1 
ATOM   1238 C CG  . TYR   A 1 161 ? -10.89186 -11.89704 -4.25120  1.000 9.86129  ? 161 TYR   A CG  1 
ATOM   1239 C CD1 . TYR   A 1 161 ? -9.82613  -12.74946 -4.53117  1.000 8.83619  ? 161 TYR   A CD1 1 
ATOM   1240 C CD2 . TYR   A 1 161 ? -11.96003 -11.87447 -5.14615  1.000 11.35719 ? 161 TYR   A CD2 1 
ATOM   1241 C CE1 . TYR   A 1 161 ? -9.81370  -13.51570 -5.65013  1.000 6.75205  ? 161 TYR   A CE1 1 
ATOM   1242 C CE2 . TYR   A 1 161 ? -11.95474 -12.64250 -6.26912  1.000 9.54460  ? 161 TYR   A CE2 1 
ATOM   1243 C CZ  . TYR   A 1 161 ? -10.87192 -13.46925 -6.52267  1.000 10.54807 ? 161 TYR   A CZ  1 
ATOM   1244 O OH  . TYR   A 1 161 ? -10.84358 -14.26834 -7.64635  1.000 8.73720  ? 161 TYR   A OH  1 
ATOM   1245 N N   . MET   A 1 162 ? -9.76680  -8.99914  -5.43209  1.000 8.11205  ? 162 MET   A N   1 
ATOM   1246 C CA  . MET   A 1 162 ? -10.18064 -8.44438  -6.72535  1.000 9.39257  ? 162 MET   A CA  1 
ATOM   1247 C C   . MET   A 1 162 ? -10.15598 -9.55154  -7.77629  1.000 5.20866  ? 162 MET   A C   1 
ATOM   1248 O O   . MET   A 1 162 ? -9.11087  -10.16871 -7.98606  1.000 4.48556  ? 162 MET   A O   1 
ATOM   1249 C CB  . MET   A 1 162 ? -9.26819  -7.29376  -7.17163  1.000 8.49419  ? 162 MET   A CB  1 
ATOM   1250 C CG  . MET   A 1 162 ? -9.61570  -6.74767  -8.57195  1.000 8.53360  ? 162 MET   A CG  1 
ATOM   1251 S SD  . MET   A 1 162 ? -9.09257  -5.02171  -8.85497  1.000 11.37415 ? 162 MET   A SD  1 
ATOM   1252 C CE  . MET   A 1 162 ? -10.41079 -4.15597  -8.00388  1.000 15.62865 ? 162 MET   A CE  1 
ATOM   1253 N N   . HIS   A 1 163 ? -11.28657 -9.77500  -8.45643  1.000 3.75710  ? 163 HIS   A N   1 
ATOM   1254 C CA  . HIS   A 1 163 ? -11.36922 -10.85174 -9.44569  1.000 12.25311 ? 163 HIS   A CA  1 
ATOM   1255 C C   . HIS   A 1 163 ? -10.59701 -10.55499 -10.73106 1.000 8.45744  ? 163 HIS   A C   1 
ATOM   1256 O O   . HIS   A 1 163 ? -10.67221 -9.45169  -11.27320 1.000 7.04095  ? 163 HIS   A O   1 
ATOM   1257 C CB  . HIS   A 1 163 ? -12.81451 -11.13774 -9.82906  1.000 10.89902 ? 163 HIS   A CB  1 
ATOM   1258 C CG  . HIS   A 1 163 ? -12.95105 -12.37843 -10.64581 1.000 8.18253  ? 163 HIS   A CG  1 
ATOM   1259 N ND1 . HIS   A 1 163 ? -13.57299 -12.40300 -11.87393 1.000 12.96982 ? 163 HIS   A ND1 1 
ATOM   1260 C CD2 . HIS   A 1 163 ? -12.50437 -13.63512 -10.42150 1.000 7.06740  ? 163 HIS   A CD2 1 
ATOM   1261 C CE1 . HIS   A 1 163 ? -13.51803 -13.62616 -12.36376 1.000 9.55953  ? 163 HIS   A CE1 1 
ATOM   1262 N NE2 . HIS   A 1 163 ? -12.86802 -14.39091 -11.50476 1.000 10.90347 ? 163 HIS   A NE2 1 
ATOM   1263 N N   . HIS   A 1 164 ? -9.90823  -11.58104 -11.25660 1.000 7.88492  ? 164 HIS   A N   1 
ATOM   1264 C CA  . HIS   A 1 164 ? -9.07933  -11.41583 -12.45507 1.000 11.83986 ? 164 HIS   A CA  1 
ATOM   1265 C C   . HIS   A 1 164 ? -9.40796  -12.38603 -13.60044 1.000 12.29454 ? 164 HIS   A C   1 
ATOM   1266 O O   . HIS   A 1 164 ? -9.31947  -11.99382 -14.76203 1.000 11.75869 ? 164 HIS   A O   1 
ATOM   1267 C CB  . HIS   A 1 164 ? -7.56863  -11.52794 -12.07004 1.000 7.01992  ? 164 HIS   A CB  1 
ATOM   1268 C CG  . HIS   A 1 164 ? -6.94561  -10.23593 -11.63913 1.000 7.29514  ? 164 HIS   A CG  1 
ATOM   1269 N ND1 . HIS   A 1 164 ? -7.16760  -9.66909  -10.40060 1.000 12.18693 ? 164 HIS   A ND1 1 
ATOM   1270 C CD2 . HIS   A 1 164 ? -6.07416  -9.41537  -12.27290 1.000 6.66378  ? 164 HIS   A CD2 1 
ATOM   1271 C CE1 . HIS   A 1 164 ? -6.48994  -8.53703  -10.30400 1.000 4.98406  ? 164 HIS   A CE1 1 
ATOM   1272 N NE2 . HIS   A 1 164 ? -5.80704  -8.36944  -11.42213 1.000 8.54091  ? 164 HIS   A NE2 1 
ATOM   1273 N N   . MET   A 1 165 ? -9.80977  -13.62764 -13.32034 1.000 16.96453 ? 165 MET   A N   1 
ATOM   1274 C CA  . MET   A 1 165 ? -9.93769  -14.60189 -14.40878 1.000 11.79771 ? 165 MET   A CA  1 
ATOM   1275 C C   . MET   A 1 165 ? -10.67465 -15.84419 -13.93259 1.000 17.62247 ? 165 MET   A C   1 
ATOM   1276 O O   . MET   A 1 165 ? -10.83504 -16.07391 -12.73054 1.000 12.08274 ? 165 MET   A O   1 
ATOM   1277 C CB  . MET   A 1 165 ? -8.57504  -15.03551 -14.91088 1.000 17.20014 ? 165 MET   A CB  1 
ATOM   1278 C CG  . MET   A 1 165 ? -7.71620  -15.45502 -13.73650 1.000 19.43094 ? 165 MET   A CG  1 
ATOM   1279 S SD  . MET   A 1 165 ? -6.06812  -15.93232 -14.22348 1.000 31.84795 ? 165 MET   A SD  1 
ATOM   1280 C CE  . MET   A 1 165 ? -5.21993  -14.43543 -13.80146 1.000 26.14970 ? 165 MET   A CE  1 
ATOM   1281 N N   . GLU   A 1 166 ? -11.05216 -16.69302 -14.89767 1.000 18.94026 ? 166 GLU   A N   1 
ATOM   1282 C CA  . GLU   A 1 166 ? -11.61240 -18.00532 -14.59948 1.000 12.02319 ? 166 GLU   A CA  1 
ATOM   1283 C C   . GLU   A 1 166 ? -10.69968 -19.09157 -15.14975 1.000 14.98762 ? 166 GLU   A C   1 
ATOM   1284 O O   . GLU   A 1 166 ? -10.31181 -19.04890 -16.31684 1.000 18.66446 ? 166 GLU   A O   1 
ATOM   1285 C CB  . GLU   A 1 166 ? -13.02510 -18.16289 -15.16478 1.000 17.23742 ? 166 GLU   A CB  1 
ATOM   1286 C CG  . GLU   A 1 166 ? -13.63237 -19.54207 -14.88537 1.000 21.09933 ? 166 GLU   A CG  1 
ATOM   1287 C CD  . GLU   A 1 166 ? -15.11570 -19.63294 -15.22182 1.000 23.73262 ? 166 GLU   A CD  1 
ATOM   1288 O OE1 . GLU   A 1 166 ? -15.52808 -20.69794 -15.73183 1.000 28.21996 ? 166 GLU   A OE1 1 
ATOM   1289 O OE2 . GLU   A 1 166 ? -15.86752 -18.65460 -14.98642 1.000 17.65710 ? 166 GLU   A OE2 1 
ATOM   1290 N N   . LEU   A 1 167 ? -10.35790 -20.04871 -14.30711 1.000 15.79156 ? 167 LEU   A N   1 
ATOM   1291 C CA  . LEU   A 1 167 ? -9.48186  -21.16420 -14.64368 1.000 16.19716 ? 167 LEU   A CA  1 
ATOM   1292 C C   . LEU   A 1 167 ? -10.27284 -22.27746 -15.32046 1.000 21.95899 ? 167 LEU   A C   1 
ATOM   1293 O O   . LEU   A 1 167 ? -11.50562 -22.25904 -15.33119 1.000 19.73477 ? 167 LEU   A O   1 
ATOM   1294 C CB  . LEU   A 1 167 ? -8.81963  -21.67504 -13.37181 1.000 23.70799 ? 167 LEU   A CB  1 
ATOM   1295 C CG  . LEU   A 1 167 ? -7.85456  -20.67848 -12.76296 1.000 19.15471 ? 167 LEU   A CG  1 
ATOM   1296 C CD1 . LEU   A 1 167 ? -7.30731  -21.22763 -11.46615 1.000 17.80564 ? 167 LEU   A CD1 1 
ATOM   1297 C CD2 . LEU   A 1 167 ? -6.75774  -20.44026 -13.78303 1.000 22.60656 ? 167 LEU   A CD2 1 
ATOM   1298 N N   . PRO   A 1 168 ? -9.58694  -23.28338 -15.89308 1.000 23.62000 ? 168 PRO   A N   1 
ATOM   1299 C CA  . PRO   A 1 168 ? -10.31775 -24.35444 -16.60879 1.000 19.35847 ? 168 PRO   A CA  1 
ATOM   1300 C C   . PRO   A 1 168 ? -11.44962 -25.00939 -15.82707 1.000 15.89674 ? 168 PRO   A C   1 
ATOM   1301 O O   . PRO   A 1 168 ? -12.54940 -25.13974 -16.37023 1.000 17.57318 ? 168 PRO   A O   1 
ATOM   1302 C CB  . PRO   A 1 168 ? -9.19816  -25.35437 -16.94713 1.000 19.77737 ? 168 PRO   A CB  1 
ATOM   1303 C CG  . PRO   A 1 168 ? -7.98403  -24.48942 -17.14793 1.000 15.70563 ? 168 PRO   A CG  1 
ATOM   1304 C CD  . PRO   A 1 168 ? -8.12849  -23.36303 -16.13955 1.000 18.68873 ? 168 PRO   A CD  1 
ATOM   1305 N N   . THR   A 1 169 ? -11.22232 -25.43937 -14.56449 1.000 18.01867 ? 169 THR   A N   1 
ATOM   1306 C CA  . THR   A 1 169 ? -12.29346 -26.14560 -13.81200 1.000 17.33540 ? 169 THR   A CA  1 
ATOM   1307 C C   . THR   A 1 169 ? -13.51338 -25.21060 -13.43845 1.000 19.79407 ? 169 THR   A C   1 
ATOM   1308 O O   . THR   A 1 169 ? -14.40713 -25.55657 -12.64209 1.000 18.47836 ? 169 THR   A O   1 
ATOM   1309 C CB  . THR   A 1 169 ? -11.73470 -26.78175 -12.52999 1.000 12.55738 ? 169 THR   A CB  1 
ATOM   1310 O OG1 . THR   A 1 169 ? -11.22289 -25.74702 -11.67441 1.000 21.83553 ? 169 THR   A OG1 1 
ATOM   1311 C CG2 . THR   A 1 169 ? -10.62522 -27.75891 -12.81724 1.000 14.10588 ? 169 THR   A CG2 1 
ATOM   1312 N N   . GLY   A 1 170 ? -13.58525 -23.99434 -13.96415 1.000 19.95028 ? 170 GLY   A N   1 
ATOM   1313 C CA  . GLY   A 1 170 ? -14.68202 -23.12305 -13.60544 1.000 25.84970 ? 170 GLY   A CA  1 
ATOM   1314 C C   . GLY   A 1 170 ? -14.52725 -22.42980 -12.27120 1.000 15.45677 ? 170 GLY   A C   1 
ATOM   1315 O O   . GLY   A 1 170 ? -15.51303 -21.87427 -11.76045 1.000 22.13072 ? 170 GLY   A O   1 
ATOM   1316 N N   . VAL   A 1 171 ? -13.33655 -22.45276 -11.68020 1.000 13.45383 ? 171 VAL   A N   1 
ATOM   1317 C CA  . VAL   A 1 171 ? -13.06755 -21.71413 -10.45359 1.000 15.29924 ? 171 VAL   A CA  1 
ATOM   1318 C C   . VAL   A 1 171 ? -12.31769 -20.44000 -10.83623 1.000 15.13055 ? 171 VAL   A C   1 
ATOM   1319 O O   . VAL   A 1 171 ? -11.93348 -20.24028 -11.98425 1.000 12.45583 ? 171 VAL   A O   1 
ATOM   1320 C CB  . VAL   A 1 171 ? -12.28632 -22.54982 -9.41254  1.000 10.06415 ? 171 VAL   A CB  1 
ATOM   1321 C CG1 . VAL   A 1 171 ? -13.05296 -23.81748 -9.01466  1.000 12.95988 ? 171 VAL   A CG1 1 
ATOM   1322 C CG2 . VAL   A 1 171 ? -10.91992 -22.89869 -9.92804  1.000 9.08982  ? 171 VAL   A CG2 1 
ATOM   1323 N N   . HIS   A 1 172 ? -12.12244 -19.56750 -9.86127  1.000 9.22229  ? 172 HIS   A N   1 
ATOM   1324 C CA  . HIS   A 1 172 ? -11.62196 -18.23669 -10.15103 1.000 11.34814 ? 172 HIS   A CA  1 
ATOM   1325 C C   . HIS   A 1 172 ? -10.38247 -17.91760 -9.32257  1.000 8.21352  ? 172 HIS   A C   1 
ATOM   1326 O O   . HIS   A 1 172 ? -10.20016 -18.40386 -8.19469  1.000 7.23484  ? 172 HIS   A O   1 
ATOM   1327 C CB  . HIS   A 1 172 ? -12.74861 -17.21405 -9.94337  1.000 12.70785 ? 172 HIS   A CB  1 
ATOM   1328 C CG  . HIS   A 1 172 ? -14.02282 -17.56794 -10.66681 1.000 13.86302 ? 172 HIS   A CG  1 
ATOM   1329 N ND1 . HIS   A 1 172 ? -15.05971 -18.25913 -10.07080 1.000 11.23482 ? 172 HIS   A ND1 1 
ATOM   1330 C CD2 . HIS   A 1 172 ? -14.41051 -17.34402 -11.94779 1.000 16.23435 ? 172 HIS   A CD2 1 
ATOM   1331 C CE1 . HIS   A 1 172 ? -16.03819 -18.42419 -10.94557 1.000 16.71774 ? 172 HIS   A CE1 1 
ATOM   1332 N NE2 . HIS   A 1 172 ? -15.66388 -17.88531 -12.09555 1.000 14.75170 ? 172 HIS   A NE2 1 
ATOM   1333 N N   . ALA   A 1 173 ? -9.52236  -17.09598 -9.91584  1.000 8.18959  ? 173 ALA   A N   1 
ATOM   1334 C CA  . ALA   A 1 173 ? -8.30181  -16.60864 -9.29220  1.000 7.43611  ? 173 ALA   A CA  1 
ATOM   1335 C C   . ALA   A 1 173 ? -8.29715  -15.08506 -9.32172  1.000 5.35254  ? 173 ALA   A C   1 
ATOM   1336 O O   . ALA   A 1 173 ? -8.85004  -14.47024 -10.23235 1.000 8.72948  ? 173 ALA   A O   1 
ATOM   1337 C CB  . ALA   A 1 173 ? -7.05023  -17.15231 -10.01228 1.000 6.99727  ? 173 ALA   A CB  1 
ATOM   1338 N N   . GLY   A 1 174 ? -7.65311  -14.47913 -8.33422  1.000 7.58237  ? 174 GLY   A N   1 
ATOM   1339 C CA  . GLY   A 1 174 ? -7.53226  -13.03441 -8.28665  1.000 5.26358  ? 174 GLY   A CA  1 
ATOM   1340 C C   . GLY   A 1 174 ? -6.39685  -12.61349 -7.37712  1.000 6.41145  ? 174 GLY   A C   1 
ATOM   1341 O O   . GLY   A 1 174 ? -5.58492  -13.43857 -6.95103  1.000 0.00008  ? 174 GLY   A O   1 
ATOM   1342 N N   . THR   A 1 175 ? -6.37449  -11.31927 -7.05823  1.000 2.77089  ? 175 THR   A N   1 
ATOM   1343 C CA  . THR   A 1 175 ? -5.33582  -10.68801 -6.24722  1.000 4.59273  ? 175 THR   A CA  1 
ATOM   1344 C C   . THR   A 1 175 ? -5.93782  -10.07172 -4.99988  1.000 4.73273  ? 175 THR   A C   1 
ATOM   1345 O O   . THR   A 1 175 ? -7.14269  -9.85033  -4.92734  1.000 3.49335  ? 175 THR   A O   1 
ATOM   1346 C CB  . THR   A 1 175 ? -4.64254  -9.55288  -7.00553  1.000 4.31355  ? 175 THR   A CB  1 
ATOM   1347 O OG1 . THR   A 1 175 ? -5.52999  -8.41560  -7.03280  1.000 4.06215  ? 175 THR   A OG1 1 
ATOM   1348 C CG2 . THR   A 1 175 ? -4.31235  -9.99431  -8.43864  1.000 4.11575  ? 175 THR   A CG2 1 
ATOM   1349 N N   . ASP   A 1 176 ? -5.06593  -9.72832  -4.04609  1.000 6.55400  ? 176 ASP   A N   1 
ATOM   1350 C CA  . ASP   A 1 176 ? -5.44959  -8.77191  -3.01322  1.000 6.33372  ? 176 ASP   A CA  1 
ATOM   1351 C C   . ASP   A 1 176 ? -5.46694  -7.37779  -3.62467  1.000 7.37850  ? 176 ASP   A C   1 
ATOM   1352 O O   . ASP   A 1 176 ? -5.19852  -7.18746  -4.82236  1.000 0.00008  ? 176 ASP   A O   1 
ATOM   1353 C CB  . ASP   A 1 176 ? -4.53349  -8.85708  -1.77439  1.000 3.67485  ? 176 ASP   A CB  1 
ATOM   1354 C CG  . ASP   A 1 176 ? -3.07761  -8.58773  -2.06251  1.000 6.88689  ? 176 ASP   A CG  1 
ATOM   1355 O OD1 . ASP   A 1 176 ? -2.72577  -8.04172  -3.14252  1.000 9.38216  ? 176 ASP   A OD1 1 
ATOM   1356 O OD2 . ASP   A 1 176 ? -2.25968  -8.91405  -1.16867  1.000 7.63549  ? 176 ASP   A OD2 1 
ATOM   1357 N N   . LEU   A 1 177 ? -5.79163  -6.38044  -2.79867  1.000 6.68614  ? 177 LEU   A N   1 
ATOM   1358 C CA  . LEU   A 1 177 ? -5.97867  -5.06126  -3.37473  1.000 6.53277  ? 177 LEU   A CA  1 
ATOM   1359 C C   . LEU   A 1 177 ? -4.66102  -4.32910  -3.59145  1.000 7.20489  ? 177 LEU   A C   1 
ATOM   1360 O O   . LEU   A 1 177 ? -4.67259  -3.24315  -4.17929  1.000 8.51806  ? 177 LEU   A O   1 
ATOM   1361 C CB  . LEU   A 1 177 ? -6.92411  -4.21383  -2.51978  1.000 4.66821  ? 177 LEU   A CB  1 
ATOM   1362 C CG  . LEU   A 1 177 ? -8.40852  -4.25821  -2.91935  1.000 5.50867  ? 177 LEU   A CG  1 
ATOM   1363 C CD1 . LEU   A 1 177 ? -8.74797  -3.53261  -4.25908  1.000 4.14711  ? 177 LEU   A CD1 1 
ATOM   1364 C CD2 . LEU   A 1 177 ? -8.89725  -5.70793  -2.96645  1.000 5.45026  ? 177 LEU   A CD2 1 
ATOM   1365 N N   . GLU   A 1 178 ? -3.53853  -4.88498  -3.14011  1.000 5.25077  ? 178 GLU   A N   1 
ATOM   1366 C CA  . GLU   A 1 178 ? -2.23320  -4.38749  -3.56604  1.000 8.10327  ? 178 GLU   A CA  1 
ATOM   1367 C C   . GLU   A 1 178 ? -1.71563  -5.10292  -4.80512  1.000 7.42158  ? 178 GLU   A C   1 
ATOM   1368 O O   . GLU   A 1 178 ? -0.52818  -4.96060  -5.13310  1.000 11.11526 ? 178 GLU   A O   1 
ATOM   1369 C CB  . GLU   A 1 178 ? -1.19095  -4.50503  -2.44831  1.000 7.10856  ? 178 GLU   A CB  1 
ATOM   1370 C CG  . GLU   A 1 178 ? -1.63695  -4.06716  -1.06033  1.000 10.34542 ? 178 GLU   A CG  1 
ATOM   1371 C CD  . GLU   A 1 178 ? -1.59605  -2.55838  -0.83876  1.000 9.47460  ? 178 GLU   A CD  1 
ATOM   1372 O OE1 . GLU   A 1 178 ? -1.85602  -2.12218  0.30857   1.000 20.05675 ? 178 GLU   A OE1 1 
ATOM   1373 O OE2 . GLU   A 1 178 ? -1.31992  -1.80773  -1.78620  1.000 21.20942 ? 178 GLU   A OE2 1 
ATOM   1374 N N   . GLY   A 1 179 ? -2.56383  -5.88129  -5.49228  1.000 7.25621  ? 179 GLY   A N   1 
ATOM   1375 C CA  . GLY   A 1 179 ? -2.22581  -6.40967  -6.80139  1.000 3.45924  ? 179 GLY   A CA  1 
ATOM   1376 C C   . GLY   A 1 179 ? -1.41265  -7.68307  -6.79874  1.000 8.95891  ? 179 GLY   A C   1 
ATOM   1377 O O   . GLY   A 1 179 ? -0.93723  -8.10722  -7.86566  1.000 4.48423  ? 179 GLY   A O   1 
ATOM   1378 N N   . ASN   A 1 180 ? -1.25011  -8.32655  -5.64306  1.000 3.82437  ? 180 ASN   A N   1 
ATOM   1379 C CA  . ASN   A 1 180 ? -0.48889  -9.55289  -5.56403  1.000 6.90122  ? 180 ASN   A CA  1 
ATOM   1380 C C   . ASN   A 1 180 ? -1.46456  -10.71649 -5.55381  1.000 6.18874  ? 180 ASN   A C   1 
ATOM   1381 O O   . ASN   A 1 180 ? -2.37560  -10.77223 -4.71243  1.000 4.43226  ? 180 ASN   A O   1 
ATOM   1382 C CB  . ASN   A 1 180 ? 0.41479   -9.56045  -4.32511  1.000 9.55914  ? 180 ASN   A CB  1 
ATOM   1383 C CG  . ASN   A 1 180 ? 1.32452   -8.33684  -4.25888  1.000 8.94599  ? 180 ASN   A CG  1 
ATOM   1384 O OD1 . ASN   A 1 180 ? 2.32664   -8.24275  -4.97089  1.000 8.04132  ? 180 ASN   A OD1 1 
ATOM   1385 N ND2 . ASN   A 1 180 ? 0.92331   -7.34512  -3.43725  1.000 8.48516  ? 180 ASN   A ND2 1 
ATOM   1386 N N   . PHE   A 1 181 ? -1.26972  -11.63238 -6.49784  1.000 5.21095  ? 181 PHE   A N   1 
ATOM   1387 C CA  . PHE   A 1 181 ? -2.16424  -12.76225 -6.65144  1.000 7.36877  ? 181 PHE   A CA  1 
ATOM   1388 C C   . PHE   A 1 181 ? -2.29775  -13.60829 -5.38233  1.000 5.78991  ? 181 PHE   A C   1 
ATOM   1389 O O   . PHE   A 1 181 ? -1.36300  -13.76460 -4.58954  1.000 2.53553  ? 181 PHE   A O   1 
ATOM   1390 C CB  . PHE   A 1 181 ? -1.69542  -13.62819 -7.82153  1.000 2.99532  ? 181 PHE   A CB  1 
ATOM   1391 C CG  . PHE   A 1 181 ? -2.43856  -13.33437 -9.08883  1.000 4.18213  ? 181 PHE   A CG  1 
ATOM   1392 C CD1 . PHE   A 1 181 ? -3.68300  -13.87632 -9.29998  1.000 5.49071  ? 181 PHE   A CD1 1 
ATOM   1393 C CD2 . PHE   A 1 181 ? -1.92626  -12.46265 -10.04509 1.000 11.19960 ? 181 PHE   A CD2 1 
ATOM   1394 C CE1 . PHE   A 1 181 ? -4.38822  -13.59436 -10.46247 1.000 4.38670  ? 181 PHE   A CE1 1 
ATOM   1395 C CE2 . PHE   A 1 181 ? -2.64068  -12.18931 -11.20450 1.000 5.63165  ? 181 PHE   A CE2 1 
ATOM   1396 C CZ  . PHE   A 1 181 ? -3.87716  -12.75569 -11.38541 1.000 6.72539  ? 181 PHE   A CZ  1 
ATOM   1397 N N   . TYR   A 1 182 ? -3.48411  -14.14938 -5.20159  1.000 4.91113  ? 182 TYR   A N   1 
ATOM   1398 C CA  . TYR   A 1 182 ? -3.66600  -15.26465 -4.28143  1.000 8.03632  ? 182 TYR   A CA  1 
ATOM   1399 C C   . TYR   A 1 182 ? -3.30536  -16.54777 -5.03755  1.000 6.32228  ? 182 TYR   A C   1 
ATOM   1400 O O   . TYR   A 1 182 ? -4.00527  -16.93826 -5.97379  1.000 7.13226  ? 182 TYR   A O   1 
ATOM   1401 C CB  . TYR   A 1 182 ? -5.09537  -15.28017 -3.74905  1.000 4.28561  ? 182 TYR   A CB  1 
ATOM   1402 C CG  . TYR   A 1 182 ? -5.43744  -14.23259 -2.68519  1.000 9.40058  ? 182 TYR   A CG  1 
ATOM   1403 C CD1 . TYR   A 1 182 ? -5.04674  -14.39459 -1.33971  1.000 5.32508  ? 182 TYR   A CD1 1 
ATOM   1404 C CD2 . TYR   A 1 182 ? -6.19832  -13.11563 -3.00862  1.000 7.43594  ? 182 TYR   A CD2 1 
ATOM   1405 C CE1 . TYR   A 1 182 ? -5.41630  -13.46763 -0.36558  1.000 7.25208  ? 182 TYR   A CE1 1 
ATOM   1406 C CE2 . TYR   A 1 182 ? -6.54792  -12.16396 -2.04786  1.000 4.66957  ? 182 TYR   A CE2 1 
ATOM   1407 C CZ  . TYR   A 1 182 ? -6.15200  -12.34223 -0.73263  1.000 8.06842  ? 182 TYR   A CZ  1 
ATOM   1408 O OH  . TYR   A 1 182 ? -6.51933  -11.41539 0.20371   1.000 3.54608  ? 182 TYR   A OH  1 
ATOM   1409 N N   . GLY   A 1 183 ? -2.18102  -17.16788 -4.68021  1.000 5.21177  ? 183 GLY   A N   1 
ATOM   1410 C CA  . GLY   A 1 183 ? -1.74206  -18.41258 -5.28554  1.000 4.76049  ? 183 GLY   A CA  1 
ATOM   1411 C C   . GLY   A 1 183 ? -0.84561  -18.25843 -6.51479  1.000 5.14779  ? 183 GLY   A C   1 
ATOM   1412 O O   . GLY   A 1 183 ? -0.47081  -17.15270 -6.91694  1.000 5.77962  ? 183 GLY   A O   1 
ATOM   1413 N N   . PRO   A 1 184 ? -0.48948  -19.38938 -7.14233  1.000 3.08566  ? 184 PRO   A N   1 
ATOM   1414 C CA  . PRO   A 1 184 ? 0.47142   -19.37412 -8.27240  1.000 5.87683  ? 184 PRO   A CA  1 
ATOM   1415 C C   . PRO   A 1 184 ? -0.20189  -19.16245 -9.61931  1.000 7.49976  ? 184 PRO   A C   1 
ATOM   1416 O O   . PRO   A 1 184 ? -0.16830  -20.03287 -10.50337 1.000 9.35886  ? 184 PRO   A O   1 
ATOM   1417 C CB  . PRO   A 1 184 ? 1.09011   -20.77683 -8.18773  1.000 6.78667  ? 184 PRO   A CB  1 
ATOM   1418 C CG  . PRO   A 1 184 ? -0.12620  -21.66457 -7.73779  1.000 6.32938  ? 184 PRO   A CG  1 
ATOM   1419 C CD  . PRO   A 1 184 ? -1.02222  -20.73524 -6.87195  1.000 5.44649  ? 184 PRO   A CD  1 
ATOM   1420 N N   . PHE   A 1 185 ? -0.81399  -17.99555 -9.80623  1.000 6.52400  ? 185 PHE   A N   1 
ATOM   1421 C CA  . PHE   A 1 185 ? -1.54074  -17.67999 -11.03265 1.000 11.75945 ? 185 PHE   A CA  1 
ATOM   1422 C C   . PHE   A 1 185 ? -1.04929  -16.35780 -11.63544 1.000 11.53684 ? 185 PHE   A C   1 
ATOM   1423 O O   . PHE   A 1 185 ? -0.49530  -15.50639 -10.93536 1.000 12.92917 ? 185 PHE   A O   1 
ATOM   1424 C CB  . PHE   A 1 185 ? -3.05307  -17.69558 -10.74954 1.000 7.10244  ? 185 PHE   A CB  1 
ATOM   1425 C CG  . PHE   A 1 185 ? -3.54746  -19.02556 -10.21397 1.000 7.30091  ? 185 PHE   A CG  1 
ATOM   1426 C CD1 . PHE   A 1 185 ? -3.49584  -20.16948 -11.01261 1.000 8.88776  ? 185 PHE   A CD1 1 
ATOM   1427 C CD2 . PHE   A 1 185 ? -4.01206  -19.15006 -8.91172  1.000 7.40162  ? 185 PHE   A CD2 1 
ATOM   1428 C CE1 . PHE   A 1 185 ? -3.92612  -21.39589 -10.54396 1.000 11.41277 ? 185 PHE   A CE1 1 
ATOM   1429 C CE2 . PHE   A 1 185 ? -4.45071  -20.39976 -8.41207  1.000 10.16346 ? 185 PHE   A CE2 1 
ATOM   1430 C CZ  . PHE   A 1 185 ? -4.39742  -21.52682 -9.23745  1.000 13.06933 ? 185 PHE   A CZ  1 
ATOM   1431 N N   . VAL   A 1 186 ? -1.20757  -16.20474 -12.95725 1.000 14.59842 ? 186 VAL   A N   1 
ATOM   1432 C CA  . VAL   A 1 186 ? -0.70298  -15.03122 -13.66882 1.000 14.05632 ? 186 VAL   A CA  1 
ATOM   1433 C C   . VAL   A 1 186 ? -1.71893  -14.51120 -14.67913 1.000 17.43436 ? 186 VAL   A C   1 
ATOM   1434 O O   . VAL   A 1 186 ? -2.54537  -15.25915 -15.21307 1.000 14.92560 ? 186 VAL   A O   1 
ATOM   1435 C CB  . VAL   A 1 186 ? 0.63815   -15.30674 -14.39495 1.000 12.08331 ? 186 VAL   A CB  1 
ATOM   1436 C CG1 . VAL   A 1 186 ? 1.76791   -15.53825 -13.38458 1.000 18.33995 ? 186 VAL   A CG1 1 
ATOM   1437 C CG2 . VAL   A 1 186 ? 0.50091   -16.48596 -15.33067 1.000 12.80424 ? 186 VAL   A CG2 1 
ATOM   1438 N N   . ASP   A 1 187 ? -1.62174  -13.20979 -14.96580 1.000 11.42878 ? 187 ASP   A N   1 
ATOM   1439 C CA  . ASP   A 1 187 ? -2.53314  -12.54903 -15.90007 1.000 15.41300 ? 187 ASP   A CA  1 
ATOM   1440 C C   . ASP   A 1 187 ? -1.92785  -12.53819 -17.30096 1.000 16.54465 ? 187 ASP   A C   1 
ATOM   1441 O O   . ASP   A 1 187 ? -1.58711  -11.50089 -17.85145 1.000 16.76542 ? 187 ASP   A O   1 
ATOM   1442 C CB  . ASP   A 1 187 ? -2.87261  -11.13655 -15.42478 1.000 14.00538 ? 187 ASP   A CB  1 
ATOM   1443 C CG  . ASP   A 1 187 ? -1.65262  -10.35364 -14.92762 1.000 12.67340 ? 187 ASP   A CG  1 
ATOM   1444 O OD1 . ASP   A 1 187 ? -0.53200  -10.88709 -14.95507 1.000 11.56236 ? 187 ASP   A OD1 1 
ATOM   1445 O OD2 . ASP   A 1 187 ? -1.82626  -9.19424  -14.48029 1.000 15.98112 ? 187 ASP   A OD2 1 
ATOM   1446 N N   . ARG   A 1 188 ? -1.74700  -13.74607 -17.83489 1.000 21.83093 ? 188 ARG   A N   1 
ATOM   1447 C CA  . ARG   A 1 188 ? -1.40001  -13.95032 -19.23729 1.000 29.48012 ? 188 ARG   A CA  1 
ATOM   1448 C C   . ARG   A 1 188 ? -1.81591  -15.36772 -19.59608 1.000 35.18712 ? 188 ARG   A C   1 
ATOM   1449 O O   . ARG   A 1 188 ? -1.49857  -16.30877 -18.86074 1.000 30.16332 ? 188 ARG   A O   1 
ATOM   1450 C CB  . ARG   A 1 188 ? 0.09573   -13.73567 -19.50606 1.000 19.09693 ? 188 ARG   A CB  1 
ATOM   1451 C CG  . ARG   A 1 188 ? 1.02058   -14.52520 -18.61549 1.000 32.58434 ? 188 ARG   A CG  1 
ATOM   1452 C CD  . ARG   A 1 188 ? 2.48570   -14.24723 -18.92194 1.000 25.48988 ? 188 ARG   A CD  1 
ATOM   1453 N NE  . ARG   A 1 188 ? 3.29227   -14.54938 -17.74970 1.000 19.58733 ? 188 ARG   A NE  1 
ATOM   1454 C CZ  . ARG   A 1 188 ? 3.85949   -15.72428 -17.50439 1.000 16.57360 ? 188 ARG   A CZ  1 
ATOM   1455 N NH1 . ARG   A 1 188 ? 3.74280   -16.72676 -18.36798 1.000 24.11274 ? 188 ARG   A NH1 1 
ATOM   1456 N NH2 . ARG   A 1 188 ? 4.56328   -15.89156 -16.39457 1.000 23.30086 ? 188 ARG   A NH2 1 
ATOM   1457 N N   . GLN   A 1 189 ? -2.53639  -15.51178 -20.70846 1.000 36.43410 ? 189 GLN   A N   1 
ATOM   1458 C CA  . GLN   A 1 189 ? -3.19529  -16.76916 -21.03969 1.000 37.51791 ? 189 GLN   A CA  1 
ATOM   1459 C C   . GLN   A 1 189 ? -2.19719  -17.90777 -21.19184 1.000 31.76408 ? 189 GLN   A C   1 
ATOM   1460 O O   . GLN   A 1 189 ? -1.47344  -17.98033 -22.18960 1.000 41.84418 ? 189 GLN   A O   1 
ATOM   1461 C CB  . GLN   A 1 189 ? -4.02619  -16.61195 -22.31527 1.000 44.45520 ? 189 GLN   A CB  1 
ATOM   1462 C CG  . GLN   A 1 189 ? -5.03168  -17.73062 -22.55592 1.000 42.23011 ? 189 GLN   A CG  1 
ATOM   1463 C CD  . GLN   A 1 189 ? -6.17791  -17.29611 -23.46326 1.000 57.94467 ? 189 GLN   A CD  1 
ATOM   1464 O OE1 . GLN   A 1 189 ? -6.34694  -16.10462 -23.75281 1.000 53.43110 ? 189 GLN   A OE1 1 
ATOM   1465 N NE2 . GLN   A 1 189 ? -6.97498  -18.26300 -23.91219 1.000 64.68958 ? 189 GLN   A NE2 1 
ATOM   1466 N N   . THR   A 1 190 ? -2.15290  -18.79335 -20.20205 1.000 26.52608 ? 190 THR   A N   1 
ATOM   1467 C CA  . THR   A 1 190 ? -1.36401  -20.01996 -20.23973 1.000 29.00244 ? 190 THR   A CA  1 
ATOM   1468 C C   . THR   A 1 190 ? -2.27534  -21.20915 -19.92842 1.000 24.99057 ? 190 THR   A C   1 
ATOM   1469 O O   . THR   A 1 190 ? -3.50318  -21.08627 -19.85824 1.000 16.37878 ? 190 THR   A O   1 
ATOM   1470 C CB  . THR   A 1 190 ? -0.18586  -19.95086 -19.25980 1.000 22.30263 ? 190 THR   A CB  1 
ATOM   1471 O OG1 . THR   A 1 190 ? -0.67665  -19.97049 -17.91077 1.000 27.94028 ? 190 THR   A OG1 1 
ATOM   1472 C CG2 . THR   A 1 190 ? 0.62509   -18.68337 -19.47677 1.000 25.38808 ? 190 THR   A CG2 1 
ATOM   1473 N N   . ALA   A 1 191 ? -1.66385  -22.37665 -19.73753 1.000 33.85978 ? 191 ALA   A N   1 
ATOM   1474 C CA  . ALA   A 1 191 ? -2.39810  -23.56988 -19.33829 1.000 25.60674 ? 191 ALA   A CA  1 
ATOM   1475 C C   . ALA   A 1 191 ? -2.50126  -23.70637 -17.82101 1.000 27.35863 ? 191 ALA   A C   1 
ATOM   1476 O O   . ALA   A 1 191 ? -2.55776  -24.82952 -17.30259 1.000 32.51719 ? 191 ALA   A O   1 
ATOM   1477 C CB  . ALA   A 1 191 ? -1.74730  -24.81318 -19.94745 1.000 20.03984 ? 191 ALA   A CB  1 
ATOM   1478 N N   . GLN   A 1 192 ? -2.51712  -22.59582 -17.08964 1.000 23.03139 ? 192 GLN   A N   1 
ATOM   1479 C CA  . GLN   A 1 192 ? -2.54726  -22.67838 -15.63520 1.000 20.40286 ? 192 GLN   A CA  1 
ATOM   1480 C C   . GLN   A 1 192 ? -3.79486  -23.40717 -15.13533 1.000 22.23459 ? 192 GLN   A C   1 
ATOM   1481 O O   . GLN   A 1 192 ? -4.88493  -23.27477 -15.70390 1.000 21.43321 ? 192 GLN   A O   1 
ATOM   1482 C CB  . GLN   A 1 192 ? -2.47140  -21.27369 -15.04540 1.000 20.90284 ? 192 GLN   A CB  1 
ATOM   1483 C CG  . GLN   A 1 192 ? -3.29329  -20.24031 -15.78574 1.000 20.97704 ? 192 GLN   A CG  1 
ATOM   1484 C CD  . GLN   A 1 192 ? -2.96461  -18.84083 -15.30528 1.000 21.31509 ? 192 GLN   A CD  1 
ATOM   1485 O OE1 . GLN   A 1 192 ? -2.27032  -18.67201 -14.30490 1.000 19.13721 ? 192 GLN   A OE1 1 
ATOM   1486 N NE2 . GLN   A 1 192 ? -3.44373  -17.83638 -16.01817 1.000 15.28711 ? 192 GLN   A NE2 1 
ATOM   1487 N N   . ALA   A 1 193 ? -3.62650  -24.18211 -14.05888 1.000 19.02218 ? 193 ALA   A N   1 
ATOM   1488 C CA  . ALA   A 1 193 ? -4.70250  -24.97950 -13.47264 1.000 23.07172 ? 193 ALA   A CA  1 
ATOM   1489 C C   . ALA   A 1 193 ? -4.64197  -24.92140 -11.94587 1.000 20.93707 ? 193 ALA   A C   1 
ATOM   1490 O O   . ALA   A 1 193 ? -3.59974  -24.62788 -11.35343 1.000 20.94141 ? 193 ALA   A O   1 
ATOM   1491 C CB  . ALA   A 1 193 ? -4.63741  -26.44476 -13.93119 1.000 22.69520 ? 193 ALA   A CB  1 
ATOM   1492 N N   . ALA   A 1 194 ? -5.76678  -25.28428 -11.31421 1.000 21.59100 ? 194 ALA   A N   1 
ATOM   1493 C CA  . ALA   A 1 194 ? -6.00118  -24.94186 -9.90944  1.000 17.82992 ? 194 ALA   A CA  1 
ATOM   1494 C C   . ALA   A 1 194 ? -5.00330  -25.60317 -8.95511  1.000 20.22465 ? 194 ALA   A C   1 
ATOM   1495 O O   . ALA   A 1 194 ? -4.52816  -24.95896 -8.01473  1.000 24.25324 ? 194 ALA   A O   1 
ATOM   1496 C CB  . ALA   A 1 194 ? -7.42753  -25.31257 -9.51216  1.000 16.53797 ? 194 ALA   A CB  1 
ATOM   1497 N N   . GLY   A 1 195 ? -4.68984  -26.87830 -9.14591  1.000 25.35477 ? 195 GLY   A N   1 
ATOM   1498 C CA  . GLY   A 1 195 ? -3.94784  -27.60580 -8.13116  1.000 17.67363 ? 195 GLY   A CA  1 
ATOM   1499 C C   . GLY   A 1 195 ? -4.87285  -28.25129 -7.10845  1.000 19.22264 ? 195 GLY   A C   1 
ATOM   1500 O O   . GLY   A 1 195 ? -6.01637  -27.84517 -6.91858  1.000 15.03571 ? 195 GLY   A O   1 
ATOM   1501 N N   . THR   A 1 196 ? -4.35339  -29.28600 -6.44049  1.000 20.63125 ? 196 THR   A N   1 
ATOM   1502 C CA  . THR   A 1 196 ? -5.15607  -30.09106 -5.52490  1.000 16.74434 ? 196 THR   A CA  1 
ATOM   1503 C C   . THR   A 1 196 ? -5.62517  -29.26294 -4.32930  1.000 16.59017 ? 196 THR   A C   1 
ATOM   1504 O O   . THR   A 1 196 ? -4.87189  -28.44997 -3.78865  1.000 15.59101 ? 196 THR   A O   1 
ATOM   1505 C CB  . THR   A 1 196 ? -4.34288  -31.29272 -5.02791  1.000 26.92368 ? 196 THR   A CB  1 
ATOM   1506 O OG1 . THR   A 1 196 ? -3.14459  -30.82683 -4.38491  1.000 31.47984 ? 196 THR   A OG1 1 
ATOM   1507 C CG2 . THR   A 1 196 ? -3.95284  -32.23971 -6.19161  1.000 21.90211 ? 196 THR   A CG2 1 
ATOM   1508 N N   . ASP   A 1 197 ? -6.87252  -29.48103 -3.90877  1.000 17.75034 ? 197 ASP   A N   1 
ATOM   1509 C CA  . ASP   A 1 197 ? -7.49494  -28.77664 -2.78788  1.000 12.95628 ? 197 ASP   A CA  1 
ATOM   1510 C C   . ASP   A 1 197 ? -7.72857  -29.73745 -1.61774  1.000 16.36428 ? 197 ASP   A C   1 
ATOM   1511 O O   . ASP   A 1 197 ? -7.65032  -30.96136 -1.76694  1.000 17.55279 ? 197 ASP   A O   1 
ATOM   1512 C CB  . ASP   A 1 197 ? -8.81485  -28.14252 -3.23830  1.000 8.76978  ? 197 ASP   A CB  1 
ATOM   1513 C CG  . ASP   A 1 197 ? -9.26292  -26.98135 -2.35150  1.000 12.13558 ? 197 ASP   A CG  1 
ATOM   1514 O OD1 . ASP   A 1 197 ? -8.44491  -26.41452 -1.59316  1.000 14.85710 ? 197 ASP   A OD1 1 
ATOM   1515 O OD2 . ASP   A 1 197 ? -10.44255 -26.59744 -2.44638  1.000 12.45037 ? 197 ASP   A OD2 1 
ATOM   1516 N N   . THR   A 1 198 ? -7.98689  -29.16537 -0.43654  1.000 9.59408  ? 198 THR   A N   1 
ATOM   1517 C CA  . THR   A 1 198 ? -8.33192  -29.90932 0.77020   1.000 14.72279 ? 198 THR   A CA  1 
ATOM   1518 C C   . THR   A 1 198 ? -9.61464  -29.32601 1.35725   1.000 15.60207 ? 198 THR   A C   1 
ATOM   1519 O O   . THR   A 1 198 ? -10.01065 -28.20967 1.02374   1.000 11.70087 ? 198 THR   A O   1 
ATOM   1520 C CB  . THR   A 1 198 ? -7.20280  -29.86657 1.85689   1.000 14.67322 ? 198 THR   A CB  1 
ATOM   1521 O OG1 . THR   A 1 198 ? -6.81932  -28.50877 2.13388   1.000 15.06420 ? 198 THR   A OG1 1 
ATOM   1522 C CG2 . THR   A 1 198 ? -5.96693  -30.63329 1.43018   1.000 17.96853 ? 198 THR   A CG2 1 
ATOM   1523 N N   . THR   A 1 199 ? -10.25508 -30.08401 2.25656   1.000 14.03477 ? 199 THR   A N   1 
ATOM   1524 C CA  . THR   A 1 199 ? -11.40046 -29.58628 3.02028   1.000 11.50486 ? 199 THR   A CA  1 
ATOM   1525 C C   . THR   A 1 199 ? -10.91049 -28.88906 4.29172   1.000 9.44158  ? 199 THR   A C   1 
ATOM   1526 O O   . THR   A 1 199 ? -9.97687  -29.35912 4.94604   1.000 10.25191 ? 199 THR   A O   1 
ATOM   1527 C CB  . THR   A 1 199 ? -12.35939 -30.73448 3.37186   1.000 11.93334 ? 199 THR   A CB  1 
ATOM   1528 O OG1 . THR   A 1 199 ? -12.95205 -31.26067 2.17460   1.000 11.98509 ? 199 THR   A OG1 1 
ATOM   1529 C CG2 . THR   A 1 199 ? -13.47448 -30.23896 4.25452   1.000 10.23208 ? 199 THR   A CG2 1 
ATOM   1530 N N   . ILE   A 1 200 ? -11.53588 -27.75566 4.63443   1.000 9.44072  ? 200 ILE   A N   1 
ATOM   1531 C CA  . ILE   A 1 200 ? -11.08370 -26.93997 5.76298   1.000 8.87394  ? 200 ILE   A CA  1 
ATOM   1532 C C   . ILE   A 1 200 ? -11.63620 -27.47093 7.09094   1.000 10.66986 ? 200 ILE   A C   1 
ATOM   1533 O O   . ILE   A 1 200 ? -12.72235 -27.06857 7.53332   1.000 11.55308 ? 200 ILE   A O   1 
ATOM   1534 C CB  . ILE   A 1 200 ? -11.46671 -25.46352 5.56209   1.000 11.80933 ? 200 ILE   A CB  1 
ATOM   1535 C CG1 . ILE   A 1 200 ? -11.11286 -24.99258 4.13937   1.000 6.81648  ? 200 ILE   A CG1 1 
ATOM   1536 C CG2 . ILE   A 1 200 ? -10.78398 -24.57174 6.63331   1.000 10.07680 ? 200 ILE   A CG2 1 
ATOM   1537 C CD1 . ILE   A 1 200 ? -11.85781 -23.72618 3.72528   1.000 5.24303  ? 200 ILE   A CD1 1 
ATOM   1538 N N   . THR   A 1 201 ? -10.85418 -28.34203 7.74953   1.000 11.63487 ? 201 THR   A N   1 
ATOM   1539 C CA  . THR   A 1 201 ? -11.30003 -29.08206 8.93749   1.000 8.35885  ? 201 THR   A CA  1 
ATOM   1540 C C   . THR   A 1 201 ? -11.89939 -28.18318 10.01691  1.000 8.96213  ? 201 THR   A C   1 
ATOM   1541 O O   . THR   A 1 201 ? -12.98943 -28.46272 10.53340  1.000 11.95070 ? 201 THR   A O   1 
ATOM   1542 C CB  . THR   A 1 201 ? -10.12638 -29.86814 9.52665   1.000 11.15505 ? 201 THR   A CB  1 
ATOM   1543 O OG1 . THR   A 1 201 ? -9.57343  -30.73138 8.52232   1.000 17.84081 ? 201 THR   A OG1 1 
ATOM   1544 C CG2 . THR   A 1 201 ? -10.60044 -30.69818 10.69990  1.000 10.60203 ? 201 THR   A CG2 1 
ATOM   1545 N N   . VAL   A 1 202 ? -11.17993 -27.12603 10.40992  1.000 7.68022  ? 202 VAL   A N   1 
ATOM   1546 C CA  . VAL   A 1 202 ? -11.63621 -26.29393 11.52568  1.000 6.49364  ? 202 VAL   A CA  1 
ATOM   1547 C C   . VAL   A 1 202 ? -13.02546 -25.72839 11.26440  1.000 9.34181  ? 202 VAL   A C   1 
ATOM   1548 O O   . VAL   A 1 202 ? -13.83835 -25.61443 12.19329  1.000 8.85546  ? 202 VAL   A O   1 
ATOM   1549 C CB  . VAL   A 1 202 ? -10.62877 -25.16980 11.82083  1.000 12.10292 ? 202 VAL   A CB  1 
ATOM   1550 C CG1 . VAL   A 1 202 ? -10.52297 -24.22356 10.63562  1.000 14.22881 ? 202 VAL   A CG1 1 
ATOM   1551 C CG2 . VAL   A 1 202 ? -11.04799 -24.40878 13.09015  1.000 19.27078 ? 202 VAL   A CG2 1 
ATOM   1552 N N   . ASN   A 1 203 ? -13.32757 -25.39691 9.99531   1.000 9.40531  ? 203 ASN   A N   1 
ATOM   1553 C CA  . ASN   A 1 203 ? -14.62668 -24.85120 9.61615   1.000 9.29164  ? 203 ASN   A CA  1 
ATOM   1554 C C   . ASN   A 1 203 ? -15.73430 -25.90130 9.74119   1.000 6.89661  ? 203 ASN   A C   1 
ATOM   1555 O O   . ASN   A 1 203 ? -16.84863 -25.57760 10.15011  1.000 8.81026  ? 203 ASN   A O   1 
ATOM   1556 C CB  . ASN   A 1 203 ? -14.58691 -24.32446 8.16737   1.000 5.90720  ? 203 ASN   A CB  1 
ATOM   1557 C CG  . ASN   A 1 203 ? -13.80272 -22.99295 8.01172   1.000 9.03643  ? 203 ASN   A CG  1 
ATOM   1558 O OD1 . ASN   A 1 203 ? -13.28241 -22.40920 8.98492   1.000 8.13870  ? 203 ASN   A OD1 1 
ATOM   1559 N ND2 . ASN   A 1 203 ? -13.76656 -22.49338 6.78519   1.000 5.64671  ? 203 ASN   A ND2 1 
ATOM   1560 N N   . VAL   A 1 204 ? -15.47780 -27.12732 9.28419   1.000 5.49499  ? 204 VAL   A N   1 
ATOM   1561 C CA  . VAL   A 1 204 ? -16.45347 -28.20567 9.42978   1.000 10.83014 ? 204 VAL   A CA  1 
ATOM   1562 C C   . VAL   A 1 204 ? -16.85021 -28.35256 10.88497  1.000 7.81940  ? 204 VAL   A C   1 
ATOM   1563 O O   . VAL   A 1 204 ? -18.03318 -28.45804 11.20827  1.000 7.34720  ? 204 VAL   A O   1 
ATOM   1564 C CB  . VAL   A 1 204 ? -15.90102 -29.53312 8.87518   1.000 11.26950 ? 204 VAL   A CB  1 
ATOM   1565 C CG1 . VAL   A 1 204 ? -16.93605 -30.65418 9.03226   1.000 9.20669  ? 204 VAL   A CG1 1 
ATOM   1566 C CG2 . VAL   A 1 204 ? -15.51179 -29.36873 7.40973   1.000 7.55982  ? 204 VAL   A CG2 1 
ATOM   1567 N N   . LEU   A 1 205 ? -15.85974 -28.35266 11.78604  1.000 8.33382  ? 205 LEU   A N   1 
ATOM   1568 C CA  . LEU   A 1 205 ? -16.16687 -28.49010 13.20807  1.000 13.64528 ? 205 LEU   A CA  1 
ATOM   1569 C C   . LEU   A 1 205 ? -17.03407 -27.33617 13.67435  1.000 8.77720  ? 205 LEU   A C   1 
ATOM   1570 O O   . LEU   A 1 205 ? -17.95878 -27.53543 14.45817  1.000 9.09320  ? 205 LEU   A O   1 
ATOM   1571 C CB  . LEU   A 1 205 ? -14.88349 -28.57338 14.05440  1.000 11.95559 ? 205 LEU   A CB  1 
ATOM   1572 C CG  . LEU   A 1 205 ? -13.98927 -29.80923 13.93412  1.000 8.22114  ? 205 LEU   A CG  1 
ATOM   1573 C CD1 . LEU   A 1 205 ? -12.60058 -29.52161 14.46830  1.000 9.20873  ? 205 LEU   A CD1 1 
ATOM   1574 C CD2 . LEU   A 1 205 ? -14.62066 -31.02000 14.64400  1.000 14.49791 ? 205 LEU   A CD2 1 
ATOM   1575 N N   . ALA   A 1 206 ? -16.77770 -26.13282 13.16293  1.000 7.98886  ? 206 ALA   A N   1 
ATOM   1576 C CA  . ALA   A 1 206 ? -17.56652 -24.96804 13.55150  1.000 9.28964  ? 206 ALA   A CA  1 
ATOM   1577 C C   . ALA   A 1 206 ? -19.00369 -25.08437 13.06413  1.000 9.10656  ? 206 ALA   A C   1 
ATOM   1578 O O   . ALA   A 1 206 ? -19.92687 -24.63699 13.74621  1.000 12.92745 ? 206 ALA   A O   1 
ATOM   1579 C CB  . ALA   A 1 206 ? -16.93142 -23.69209 13.00771  1.000 8.69216  ? 206 ALA   A CB  1 
ATOM   1580 N N   . TRP   A 1 207 ? -19.20389 -25.71392 11.91122  1.000 9.97546  ? 207 TRP   A N   1 
ATOM   1581 C CA  . TRP   A 1 207 ? -20.52423 -25.89775 11.31944  1.000 11.87777 ? 207 TRP   A CA  1 
ATOM   1582 C C   . TRP   A 1 207 ? -21.30076 -26.99969 12.04086  1.000 12.61799 ? 207 TRP   A C   1 
ATOM   1583 O O   . TRP   A 1 207 ? -22.49785 -26.84696 12.31377  1.000 10.05331 ? 207 TRP   A O   1 
ATOM   1584 C CB  . TRP   A 1 207 ? -20.34388 -26.18782 9.82449   1.000 6.64909  ? 207 TRP   A CB  1 
ATOM   1585 C CG  . TRP   A 1 207 ? -21.55098 -26.68154 9.05035   1.000 7.63538  ? 207 TRP   A CG  1 
ATOM   1586 C CD1 . TRP   A 1 207 ? -22.56858 -25.93128 8.54146   1.000 7.19897  ? 207 TRP   A CD1 1 
ATOM   1587 C CD2 . TRP   A 1 207 ? -21.83593 -28.03388 8.69813   1.000 9.66897  ? 207 TRP   A CD2 1 
ATOM   1588 N NE1 . TRP   A 1 207 ? -23.47183 -26.73184 7.88007   1.000 10.49165 ? 207 TRP   A NE1 1 
ATOM   1589 C CE2 . TRP   A 1 207 ? -23.03934 -28.03019 7.95858   1.000 15.95715 ? 207 TRP   A CE2 1 
ATOM   1590 C CE3 . TRP   A 1 207 ? -21.18777 -29.25693 8.93171   1.000 8.04872  ? 207 TRP   A CE3 1 
ATOM   1591 C CZ2 . TRP   A 1 207 ? -23.59748 -29.19786 7.44716   1.000 10.82666 ? 207 TRP   A CZ2 1 
ATOM   1592 C CZ3 . TRP   A 1 207 ? -21.74764 -30.41308 8.42271   1.000 11.27715 ? 207 TRP   A CZ3 1 
ATOM   1593 C CH2 . TRP   A 1 207 ? -22.93857 -30.37611 7.69449   1.000 8.30514  ? 207 TRP   A CH2 1 
ATOM   1594 N N   . LEU   A 1 208 ? -20.62554 -28.09826 12.39776  1.000 13.01962 ? 208 LEU   A N   1 
ATOM   1595 C CA  . LEU   A 1 208 ? -21.24746 -29.08876 13.27599  1.000 12.41063 ? 208 LEU   A CA  1 
ATOM   1596 C C   . LEU   A 1 208 ? -21.73496 -28.45377 14.58278  1.000 13.01496 ? 208 LEU   A C   1 
ATOM   1597 O O   . LEU   A 1 208 ? -22.84842 -28.74265 15.05190  1.000 15.53363 ? 208 LEU   A O   1 
ATOM   1598 C CB  . LEU   A 1 208 ? -20.26110 -30.22824 13.54176  1.000 11.42089 ? 208 LEU   A CB  1 
ATOM   1599 C CG  . LEU   A 1 208 ? -19.98814 -31.13597 12.33367  1.000 10.78232 ? 208 LEU   A CG  1 
ATOM   1600 C CD1 . LEU   A 1 208 ? -18.96482 -32.22614 12.63139  1.000 11.31299 ? 208 LEU   A CD1 1 
ATOM   1601 C CD2 . LEU   A 1 208 ? -21.28155 -31.76731 11.87716  1.000 11.11242 ? 208 LEU   A CD2 1 
ATOM   1602 N N   . TYR   A 1 209 ? -20.92981 -27.56094 15.17216  1.000 11.50893 ? 209 TYR   A N   1 
ATOM   1603 C CA  . TYR   A 1 209 ? -21.37570 -26.83650 16.35877  1.000 10.96388 ? 209 TYR   A CA  1 
ATOM   1604 C C   . TYR   A 1 209 ? -22.57771 -25.93732 16.07407  1.000 13.29295 ? 209 TYR   A C   1 
ATOM   1605 O O   . TYR   A 1 209 ? -23.39063 -25.68855 16.97816  1.000 12.92910 ? 209 TYR   A O   1 
ATOM   1606 C CB  . TYR   A 1 209 ? -20.24015 -25.98884 16.91429  1.000 12.04001 ? 209 TYR   A CB  1 
ATOM   1607 C CG  . TYR   A 1 209 ? -19.27590 -26.73054 17.78866  1.000 18.08737 ? 209 TYR   A CG  1 
ATOM   1608 C CD1 . TYR   A 1 209 ? -19.66569 -27.26522 19.01308  1.000 14.86926 ? 209 TYR   A CD1 1 
ATOM   1609 C CD2 . TYR   A 1 209 ? -17.95844 -26.87154 17.40430  1.000 15.52055 ? 209 TYR   A CD2 1 
ATOM   1610 C CE1 . TYR   A 1 209 ? -18.76237 -27.92366 19.80515  1.000 15.90555 ? 209 TYR   A CE1 1 
ATOM   1611 C CE2 . TYR   A 1 209 ? -17.06072 -27.54545 18.18261  1.000 12.41723 ? 209 TYR   A CE2 1 
ATOM   1612 C CZ  . TYR   A 1 209 ? -17.45848 -28.06431 19.37221  1.000 15.10045 ? 209 TYR   A CZ  1 
ATOM   1613 O OH  . TYR   A 1 209 ? -16.51428 -28.70837 20.12815  1.000 18.98393 ? 209 TYR   A OH  1 
ATOM   1614 N N   . ALA   A 1 210 ? -22.68501 -25.40041 14.85192  1.000 10.89540 ? 210 ALA   A N   1 
ATOM   1615 C CA  . ALA   A 1 210 ? -23.86713 -24.61288 14.50001  1.000 13.52818 ? 210 ALA   A CA  1 
ATOM   1616 C C   . ALA   A 1 210 ? -25.10880 -25.48271 14.43098  1.000 11.70686 ? 210 ALA   A C   1 
ATOM   1617 O O   . ALA   A 1 210 ? -26.21072 -25.01751 14.74260  1.000 10.02600 ? 210 ALA   A O   1 
ATOM   1618 C CB  . ALA   A 1 210 ? -23.66844 -23.88780 13.16222  1.000 13.00714 ? 210 ALA   A CB  1 
ATOM   1619 N N   . ALA   A 1 211 ? -24.94382 -26.74236 14.02391  1.000 13.74266 ? 211 ALA   A N   1 
ATOM   1620 C CA  . ALA   A 1 211 ? -26.07978 -27.64344 13.88350  1.000 11.62102 ? 211 ALA   A CA  1 
ATOM   1621 C C   . ALA   A 1 211 ? -26.57895 -28.13918 15.23699  1.000 12.80504 ? 211 ALA   A C   1 
ATOM   1622 O O   . ALA   A 1 211 ? -27.77283 -28.40126 15.40010  1.000 10.58168 ? 211 ALA   A O   1 
ATOM   1623 C CB  . ALA   A 1 211 ? -25.69876 -28.82616 12.99304  1.000 18.52037 ? 211 ALA   A CB  1 
ATOM   1624 N N   . VAL   A 1 212 ? -25.67642 -28.32920 16.19865  1.000 9.27524  ? 212 VAL   A N   1 
ATOM   1625 C CA  . VAL   A 1 212 ? -26.10811 -28.61931 17.56382  1.000 17.61376 ? 212 VAL   A CA  1 
ATOM   1626 C C   . VAL   A 1 212 ? -26.89468 -27.44132 18.12650  1.000 15.97305 ? 212 VAL   A C   1 
ATOM   1627 O O   . VAL   A 1 212 ? -27.95518 -27.61392 18.73853  1.000 15.63285 ? 212 VAL   A O   1 
ATOM   1628 C CB  . VAL   A 1 212 ? -24.89929 -28.95552 18.45710  1.000 18.25676 ? 212 VAL   A CB  1 
ATOM   1629 C CG1 . VAL   A 1 212 ? -25.31349 -28.93315 19.94497  1.000 16.72378 ? 212 VAL   A CG1 1 
ATOM   1630 C CG2 . VAL   A 1 212 ? -24.29319 -30.27829 18.05504  1.000 14.11559 ? 212 VAL   A CG2 1 
ATOM   1631 N N   . ILE   A 1 213 ? -26.36893 -26.22376 17.94884  1.000 16.14549 ? 213 ILE   A N   1 
ATOM   1632 C CA  . ILE   A 1 213 ? -27.05223 -25.02929 18.44455  1.000 12.71546 ? 213 ILE   A CA  1 
ATOM   1633 C C   . ILE   A 1 213 ? -28.42747 -24.89986 17.80562  1.000 14.16894 ? 213 ILE   A C   1 
ATOM   1634 O O   . ILE   A 1 213 ? -29.36373 -24.40553 18.43197  1.000 19.54413 ? 213 ILE   A O   1 
ATOM   1635 C CB  . ILE   A 1 213 ? -26.18052 -23.77740 18.21322  1.000 17.34522 ? 213 ILE   A CB  1 
ATOM   1636 C CG1 . ILE   A 1 213 ? -24.89966 -23.85374 19.04820  1.000 16.06302 ? 213 ILE   A CG1 1 
ATOM   1637 C CG2 . ILE   A 1 213 ? -26.91892 -22.49977 18.58841  1.000 20.13024 ? 213 ILE   A CG2 1 
ATOM   1638 C CD1 . ILE   A 1 213 ? -23.86278 -22.82673 18.65320  1.000 16.78640 ? 213 ILE   A CD1 1 
ATOM   1639 N N   . ASN   A 1 214 ? -28.59882 -25.39440 16.58529  1.000 16.42174 ? 214 ASN   A N   1 
ATOM   1640 C CA  . ASN   A 1 214 ? -29.89247 -25.29342 15.93030  1.000 16.44756 ? 214 ASN   A CA  1 
ATOM   1641 C C   . ASN   A 1 214 ? -30.73886 -26.55766 16.02258  1.000 15.53311 ? 214 ASN   A C   1 
ATOM   1642 O O   . ASN   A 1 214 ? -31.85997 -26.57028 15.50495  1.000 16.19624 ? 214 ASN   A O   1 
ATOM   1643 C CB  . ASN   A 1 214 ? -29.70783 -24.89793 14.47259  1.000 19.50793 ? 214 ASN   A CB  1 
ATOM   1644 C CG  . ASN   A 1 214 ? -29.52581 -23.41050 14.31714  1.000 19.12540 ? 214 ASN   A CG  1 
ATOM   1645 O OD1 . ASN   A 1 214 ? -30.49323 -22.66681 14.19408  1.000 20.69325 ? 214 ASN   A OD1 1 
ATOM   1646 N ND2 . ASN   A 1 214 ? -28.28333 -22.96303 14.36297  1.000 18.90855 ? 214 ASN   A ND2 1 
ATOM   1647 N N   . GLY   A 1 215 ? -30.24569 -27.61716 16.65084  1.000 15.75123 ? 215 GLY   A N   1 
ATOM   1648 C CA  . GLY   A 1 215 ? -31.08568 -28.74954 16.99258  1.000 20.20804 ? 215 GLY   A CA  1 
ATOM   1649 C C   . GLY   A 1 215 ? -30.84017 -30.04709 16.25111  1.000 18.70772 ? 215 GLY   A C   1 
ATOM   1650 O O   . GLY   A 1 215 ? -31.62527 -30.98165 16.42392  1.000 19.51155 ? 215 GLY   A O   1 
ATOM   1651 N N   . ASP   A 1 216 ? -29.79033 -30.14994 15.43749  1.000 21.12880 ? 216 ASP   A N   1 
ATOM   1652 C CA  . ASP   A 1 216 ? -29.44570 -31.41657 14.78204  1.000 20.51610 ? 216 ASP   A CA  1 
ATOM   1653 C C   . ASP   A 1 216 ? -28.41789 -32.13995 15.64699  1.000 20.36436 ? 216 ASP   A C   1 
ATOM   1654 O O   . ASP   A 1 216 ? -27.22971 -31.80508 15.62108  1.000 14.51920 ? 216 ASP   A O   1 
ATOM   1655 C CB  . ASP   A 1 216 ? -28.87178 -31.18315 13.38722  1.000 23.65998 ? 216 ASP   A CB  1 
ATOM   1656 C CG  . ASP   A 1 216 ? -29.87037 -30.59929 12.42052  1.000 26.22801 ? 216 ASP   A CG  1 
ATOM   1657 O OD1 . ASP   A 1 216 ? -31.07128 -30.56903 12.75039  1.000 30.77711 ? 216 ASP   A OD1 1 
ATOM   1658 O OD2 . ASP   A 1 216 ? -29.44279 -30.18160 11.31300  1.000 29.72100 ? 216 ASP   A OD2 1 
ATOM   1659 N N   . ARG   A 1 217 ? -28.84835 -33.15247 16.40450  1.000 22.04280 ? 217 ARG   A N   1 
ATOM   1660 C CA  . ARG   A 1 217 ? -27.91955 -33.83504 17.30320  1.000 23.44310 ? 217 ARG   A CA  1 
ATOM   1661 C C   . ARG   A 1 217 ? -27.66859 -35.29450 16.95855  1.000 18.46627 ? 217 ARG   A C   1 
ATOM   1662 O O   . ARG   A 1 217 ? -26.93492 -35.95885 17.69658  1.000 15.82402 ? 217 ARG   A O   1 
ATOM   1663 C CB  . ARG   A 1 217 ? -28.40328 -33.74178 18.75502  1.000 18.42724 ? 217 ARG   A CB  1 
ATOM   1664 C CG  . ARG   A 1 217 ? -28.47462 -32.32392 19.27673  1.000 23.62449 ? 217 ARG   A CG  1 
ATOM   1665 C CD  . ARG   A 1 217 ? -29.14952 -32.27151 20.64718  1.000 27.75237 ? 217 ARG   A CD  1 
ATOM   1666 N NE  . ARG   A 1 217 ? -28.30730 -32.88176 21.66707  1.000 26.44403 ? 217 ARG   A NE  1 
ATOM   1667 C CZ  . ARG   A 1 217 ? -27.47768 -32.20311 22.45884  1.000 27.31091 ? 217 ARG   A CZ  1 
ATOM   1668 N NH1 . ARG   A 1 217 ? -27.39260 -30.87891 22.36844  1.000 20.64454 ? 217 ARG   A NH1 1 
ATOM   1669 N NH2 . ARG   A 1 217 ? -26.73673 -32.84890 23.34815  1.000 16.41083 ? 217 ARG   A NH2 1 
ATOM   1670 N N   . TRP   A 1 218 ? -28.21559 -35.79332 15.84133  1.000 21.25359 ? 218 TRP   A N   1 
ATOM   1671 C CA  . TRP   A 1 218 ? -28.19996 -37.22166 15.52523  1.000 15.84570 ? 218 TRP   A CA  1 
ATOM   1672 C C   . TRP   A 1 218 ? -26.79780 -37.79039 15.33513  1.000 20.04719 ? 218 TRP   A C   1 
ATOM   1673 O O   . TRP   A 1 218 ? -26.60585 -39.00554 15.48211  1.000 14.44532 ? 218 TRP   A O   1 
ATOM   1674 C CB  . TRP   A 1 218 ? -29.02277 -37.46449 14.26651  1.000 21.47434 ? 218 TRP   A CB  1 
ATOM   1675 C CG  . TRP   A 1 218 ? -28.45391 -36.83553 12.99388  1.000 22.42145 ? 218 TRP   A CG  1 
ATOM   1676 C CD1 . TRP   A 1 218 ? -28.85276 -35.66807 12.40631  1.000 21.05706 ? 218 TRP   A CD1 1 
ATOM   1677 C CD2 . TRP   A 1 218 ? -27.41682 -37.36835 12.15847  1.000 19.90161 ? 218 TRP   A CD2 1 
ATOM   1678 N NE1 . TRP   A 1 218 ? -28.12055 -35.43451 11.26198  1.000 23.78891 ? 218 TRP   A NE1 1 
ATOM   1679 C CE2 . TRP   A 1 218 ? -27.23749 -36.46707 11.08559  1.000 23.68656 ? 218 TRP   A CE2 1 
ATOM   1680 C CE3 . TRP   A 1 218 ? -26.61361 -38.51338 12.22043  1.000 21.02721 ? 218 TRP   A CE3 1 
ATOM   1681 C CZ2 . TRP   A 1 218 ? -26.29155 -36.67608 10.08347  1.000 25.06164 ? 218 TRP   A CZ2 1 
ATOM   1682 C CZ3 . TRP   A 1 218 ? -25.67419 -38.72160 11.22798  1.000 24.13719 ? 218 TRP   A CZ3 1 
ATOM   1683 C CH2 . TRP   A 1 218 ? -25.52055 -37.80383 10.16973  1.000 30.61002 ? 218 TRP   A CH2 1 
ATOM   1684 N N   . PHE   A 1 219 ? -25.83043 -36.94782 14.97104  1.000 21.34517 ? 219 PHE   A N   1 
ATOM   1685 C CA  . PHE   A 1 219 ? -24.44348 -37.34345 14.75236  1.000 20.99163 ? 219 PHE   A CA  1 
ATOM   1686 C C   . PHE   A 1 219 ? -23.58213 -37.22922 16.00827  1.000 17.88057 ? 219 PHE   A C   1 
ATOM   1687 O O   . PHE   A 1 219 ? -22.40383 -37.60711 15.97348  1.000 18.07440 ? 219 PHE   A O   1 
ATOM   1688 C CB  . PHE   A 1 219 ? -23.83376 -36.48552 13.63542  1.000 18.24704 ? 219 PHE   A CB  1 
ATOM   1689 C CG  . PHE   A 1 219 ? -23.94995 -35.01108 13.88335  1.000 18.27850 ? 219 PHE   A CG  1 
ATOM   1690 C CD1 . PHE   A 1 219 ? -25.08697 -34.31601 13.49791  1.000 15.81045 ? 219 PHE   A CD1 1 
ATOM   1691 C CD2 . PHE   A 1 219 ? -22.93423 -34.32024 14.53030  1.000 18.38188 ? 219 PHE   A CD2 1 
ATOM   1692 C CE1 . PHE   A 1 219 ? -25.19665 -32.96094 13.73591  1.000 18.25812 ? 219 PHE   A CE1 1 
ATOM   1693 C CE2 . PHE   A 1 219 ? -23.04015 -32.95039 14.77068  1.000 17.21116 ? 219 PHE   A CE2 1 
ATOM   1694 C CZ  . PHE   A 1 219 ? -24.17341 -32.27739 14.37620  1.000 15.60640 ? 219 PHE   A CZ  1 
ATOM   1695 N N   . LEU   A 1 220 ? -24.12567 -36.69976 17.10293  1.000 18.41075 ? 220 LEU   A N   1 
ATOM   1696 C CA  . LEU   A 1 220 ? -23.38024 -36.69351 18.34903  1.000 17.95651 ? 220 LEU   A CA  1 
ATOM   1697 C C   . LEU   A 1 220 ? -23.23678 -38.12217 18.87016  1.000 23.24927 ? 220 LEU   A C   1 
ATOM   1698 O O   . LEU   A 1 220 ? -23.94683 -39.04547 18.45032  1.000 20.63442 ? 220 LEU   A O   1 
ATOM   1699 C CB  . LEU   A 1 220 ? -24.06333 -35.79915 19.38116  1.000 17.34754 ? 220 LEU   A CB  1 
ATOM   1700 C CG  . LEU   A 1 220 ? -23.91253 -34.28423 19.24497  1.000 17.61235 ? 220 LEU   A CG  1 
ATOM   1701 C CD1 . LEU   A 1 220 ? -24.68021 -33.60226 20.35982  1.000 16.15585 ? 220 LEU   A CD1 1 
ATOM   1702 C CD2 . LEU   A 1 220 ? -22.41703 -33.85792 19.24275  1.000 14.34733 ? 220 LEU   A CD2 1 
ATOM   1703 N N   . ASN   A 1 221 ? -22.28836 -38.30654 19.78211  1.000 21.95478 ? 221 ASN   A N   1 
ATOM   1704 C CA  . ASN   A 1 221 ? -21.98039 -39.63668 20.29124  1.000 28.63754 ? 221 ASN   A CA  1 
ATOM   1705 C C   . ASN   A 1 221 ? -21.14419 -39.49029 21.54753  1.000 27.72559 ? 221 ASN   A C   1 
ATOM   1706 O O   . ASN   A 1 221 ? -20.63025 -38.41126 21.85864  1.000 26.07176 ? 221 ASN   A O   1 
ATOM   1707 C CB  . ASN   A 1 221 ? -21.25973 -40.47973 19.24262  1.000 31.90399 ? 221 ASN   A CB  1 
ATOM   1708 C CG  . ASN   A 1 221 ? -20.05946 -39.77527 18.68000  1.000 34.45871 ? 221 ASN   A CG  1 
ATOM   1709 O OD1 . ASN   A 1 221 ? -19.07566 -39.52354 19.38647  1.000 35.64887 ? 221 ASN   A OD1 1 
ATOM   1710 N ND2 . ASN   A 1 221 ? -20.15652 -39.38181 17.41382  1.000 31.51521 ? 221 ASN   A ND2 1 
ATOM   1711 N N   . ARG   A 1 222 ? -21.02273 -40.59872 22.27231  1.000 31.50488 ? 222 ARG   A N   1 
ATOM   1712 C CA  . ARG   A 1 222 ? -20.39080 -40.57198 23.58016  1.000 32.20829 ? 222 ARG   A CA  1 
ATOM   1713 C C   . ARG   A 1 222 ? -18.87468 -40.58655 23.51787  1.000 28.96158 ? 222 ARG   A C   1 
ATOM   1714 O O   . ARG   A 1 222 ? -18.24409 -40.41254 24.56172  1.000 32.72190 ? 222 ARG   A O   1 
ATOM   1715 C CB  . ARG   A 1 222 ? -20.83550 -41.77119 24.42241  1.000 33.99639 ? 222 ARG   A CB  1 
ATOM   1716 C CG  . ARG   A 1 222 ? -20.35548 -43.10960 23.87899  1.000 34.72992 ? 222 ARG   A CG  1 
ATOM   1717 C CD  . ARG   A 1 222 ? -20.89725 -44.30226 24.64204  1.000 32.82260 ? 222 ARG   A CD  1 
ATOM   1718 N NE  . ARG   A 1 222 ? -20.01072 -44.74280 25.70870  1.000 42.13389 ? 222 ARG   A NE  1 
ATOM   1719 C CZ  . ARG   A 1 222 ? -20.39313 -45.49759 26.73387  1.000 40.94843 ? 222 ARG   A CZ  1 
ATOM   1720 N NH1 . ARG   A 1 222 ? -21.65776 -45.88873 26.84546  1.000 37.23545 ? 222 ARG   A NH1 1 
ATOM   1721 N NH2 . ARG   A 1 222 ? -19.50872 -45.85886 27.65022  1.000 50.77695 ? 222 ARG   A NH2 1 
ATOM   1722 N N   . PHE   A 1 223 ? -18.26269 -40.77874 22.34730  1.000 36.96326 ? 223 PHE   A N   1 
ATOM   1723 C CA  . PHE   A 1 223 ? -16.91709 -41.31122 22.41721  1.000 33.81901 ? 223 PHE   A CA  1 
ATOM   1724 C C   . PHE   A 1 223 ? -16.00441 -40.09216 22.42428  1.000 28.85682 ? 223 PHE   A C   1 
ATOM   1725 O O   . PHE   A 1 223 ? -16.47137 -38.95384 22.31501  1.000 26.60078 ? 223 PHE   A O   1 
ATOM   1726 C CB  . PHE   A 1 223 ? -16.50328 -42.23658 21.25114  1.000 31.91915 ? 223 PHE   A CB  1 
ATOM   1727 C CG  . PHE   A 1 223 ? -17.58382 -43.18016 20.71829  1.000 36.01921 ? 223 PHE   A CG  1 
ATOM   1728 C CD1 . PHE   A 1 223 ? -18.93716 -42.93524 20.90190  1.000 38.56163 ? 223 PHE   A CD1 1 
ATOM   1729 C CD2 . PHE   A 1 223 ? -17.22551 -44.45038 20.29700  1.000 43.16839 ? 223 PHE   A CD2 1 
ATOM   1730 C CE1 . PHE   A 1 223 ? -19.91018 -43.78216 20.42740  1.000 37.29489 ? 223 PHE   A CE1 1 
ATOM   1731 C CE2 . PHE   A 1 223 ? -18.20072 -45.36566 19.88291  1.000 48.84383 ? 223 PHE   A CE2 1 
ATOM   1732 C CZ  . PHE   A 1 223 ? -19.55072 -45.01990 19.95219  1.000 46.98127 ? 223 PHE   A CZ  1 
ATOM   1733 N N   . THR   A 1 224 ? -14.69579 -40.31511 22.53881  1.000 21.85038 ? 224 THR   A N   1 
ATOM   1734 C CA  . THR   A 1 224 ? -13.72778 -39.24530 22.35075  1.000 26.64324 ? 224 THR   A CA  1 
ATOM   1735 C C   . THR   A 1 224 ? -12.54227 -39.78745 21.56038  1.000 27.14457 ? 224 THR   A C   1 
ATOM   1736 O O   . THR   A 1 224 ? -12.48834 -40.96866 21.20466  1.000 31.54631 ? 224 THR   A O   1 
ATOM   1737 C CB  . THR   A 1 224 ? -13.29098 -38.63663 23.69050  1.000 34.30798 ? 224 THR   A CB  1 
ATOM   1738 O OG1 . THR   A 1 224 ? -12.64418 -37.37776 23.45607  1.000 25.87140 ? 224 THR   A OG1 1 
ATOM   1739 C CG2 . THR   A 1 224 ? -12.34411 -39.57747 24.45270  1.000 23.12559 ? 224 THR   A CG2 1 
ATOM   1740 N N   . THR   A 1 225 ? -11.59995 -38.90442 21.25660  1.000 27.94044 ? 225 THR   A N   1 
ATOM   1741 C CA  . THR   A 1 225 ? -10.35826 -39.29922 20.60229  1.000 33.72351 ? 225 THR   A CA  1 
ATOM   1742 C C   . THR   A 1 225 ? -9.29117  -38.26423 20.92851  1.000 27.38649 ? 225 THR   A C   1 
ATOM   1743 O O   . THR   A 1 225 ? -9.56504  -37.22893 21.54460  1.000 21.42916 ? 225 THR   A O   1 
ATOM   1744 C CB  . THR   A 1 225 ? -10.52882 -39.45546 19.08766  1.000 30.11063 ? 225 THR   A CB  1 
ATOM   1745 O OG1 . THR   A 1 225 ? -9.29433  -39.89866 18.50933  1.000 27.35680 ? 225 THR   A OG1 1 
ATOM   1746 C CG2 . THR   A 1 225 ? -10.95612 -38.13789 18.44441  1.000 32.84499 ? 225 THR   A CG2 1 
ATOM   1747 N N   . THR   A 1 226 ? -8.06196  -38.57183 20.52275  1.000 26.82746 ? 226 THR   A N   1 
ATOM   1748 C CA  . THR   A 1 226 ? -6.95802  -37.64126 20.68573  1.000 24.64278 ? 226 THR   A CA  1 
ATOM   1749 C C   . THR   A 1 226 ? -6.79690  -36.78472 19.43823  1.000 28.24817 ? 226 THR   A C   1 
ATOM   1750 O O   . THR   A 1 226 ? -7.16683  -37.18377 18.32867  1.000 27.45223 ? 226 THR   A O   1 
ATOM   1751 C CB  . THR   A 1 226 ? -5.64000  -38.36922 20.97539  1.000 30.10801 ? 226 THR   A CB  1 
ATOM   1752 O OG1 . THR   A 1 226 ? -5.44328  -39.43054 20.02783  1.000 25.48659 ? 226 THR   A OG1 1 
ATOM   1753 C CG2 . THR   A 1 226 ? -5.62511  -38.91670 22.39715  1.000 27.86754 ? 226 THR   A CG2 1 
ATOM   1754 N N   . LEU   A 1 227 ? -6.23146  -35.59284 19.64164  1.000 21.59604 ? 227 LEU   A N   1 
ATOM   1755 C CA  . LEU   A 1 227 ? -5.85147  -34.72998 18.53516  1.000 24.63974 ? 227 LEU   A CA  1 
ATOM   1756 C C   . LEU   A 1 227 ? -4.98904  -35.46817 17.52334  1.000 26.14246 ? 227 LEU   A C   1 
ATOM   1757 O O   . LEU   A 1 227 ? -5.02372  -35.15822 16.32936  1.000 23.77322 ? 227 LEU   A O   1 
ATOM   1758 C CB  . LEU   A 1 227 ? -5.12057  -33.51065 19.09888  1.000 24.70461 ? 227 LEU   A CB  1 
ATOM   1759 C CG  . LEU   A 1 227 ? -4.62284  -32.37643 18.20265  1.000 26.74877 ? 227 LEU   A CG  1 
ATOM   1760 C CD1 . LEU   A 1 227 ? -5.69993  -31.94840 17.21324  1.000 26.75247 ? 227 LEU   A CD1 1 
ATOM   1761 C CD2 . LEU   A 1 227 ? -4.16442  -31.20053 19.07246  1.000 19.75249 ? 227 LEU   A CD2 1 
ATOM   1762 N N   . ASN   A 1 228 ? -4.21576  -36.45509 17.97713  1.000 26.97988 ? 228 ASN   A N   1 
ATOM   1763 C CA  . ASN   A 1 228 ? -3.27622  -37.12581 17.08697  1.000 30.00453 ? 228 ASN   A CA  1 
ATOM   1764 C C   . ASN   A 1 228 ? -3.96855  -38.20826 16.27334  1.000 27.03994 ? 228 ASN   A C   1 
ATOM   1765 O O   . ASN   A 1 228 ? -3.75386  -38.31672 15.06058  1.000 25.77086 ? 228 ASN   A O   1 
ATOM   1766 C CB  . ASN   A 1 228 ? -2.10945  -37.70826 17.89248  1.000 25.35633 ? 228 ASN   A CB  1 
ATOM   1767 C CG  . ASN   A 1 228 ? -1.18020  -36.63944 18.41076  1.000 22.54970 ? 228 ASN   A CG  1 
ATOM   1768 O OD1 . ASN   A 1 228 ? -1.19615  -35.50152 17.93318  1.000 29.32779 ? 228 ASN   A OD1 1 
ATOM   1769 N ND2 . ASN   A 1 228 ? -0.34321  -36.99841 19.37371  1.000 28.18379 ? 228 ASN   A ND2 1 
ATOM   1770 N N   . ASP   A 1 229 ? -4.81313  -39.01020 16.92929  1.000 27.54394 ? 229 ASP   A N   1 
ATOM   1771 C CA  . ASP   A 1 229 ? -5.54397  -40.06050 16.22880  1.000 32.39962 ? 229 ASP   A CA  1 
ATOM   1772 C C   . ASP   A 1 229 ? -6.59199  -39.48206 15.28393  1.000 30.58516 ? 229 ASP   A C   1 
ATOM   1773 O O   . ASP   A 1 229 ? -6.89386  -40.08994 14.25035  1.000 26.26038 ? 229 ASP   A O   1 
ATOM   1774 C CB  . ASP   A 1 229 ? -6.18531  -41.00784 17.24602  1.000 31.53717 ? 229 ASP   A CB  1 
ATOM   1775 C CG  . ASP   A 1 229 ? -5.15655  -41.87234 17.95030  1.000 42.40591 ? 229 ASP   A CG  1 
ATOM   1776 O OD1 . ASP   A 1 229 ? -4.38556  -42.54381 17.23225  1.000 38.37853 ? 229 ASP   A OD1 1 
ATOM   1777 O OD2 . ASP   A 1 229 ? -5.08117  -41.84639 19.20438  1.000 35.70500 ? 229 ASP   A OD2 1 
ATOM   1778 N N   . PHE   A 1 230 ? -7.15182  -38.31304 15.60621  1.000 22.63551 ? 230 PHE   A N   1 
ATOM   1779 C CA  . PHE   A 1 230 ? -8.08075  -37.70885 14.66614  1.000 24.72765 ? 230 PHE   A CA  1 
ATOM   1780 C C   . PHE   A 1 230 ? -7.35866  -37.20435 13.42439  1.000 23.58619 ? 230 PHE   A C   1 
ATOM   1781 O O   . PHE   A 1 230 ? -7.93389  -37.19881 12.33481  1.000 23.98411 ? 230 PHE   A O   1 
ATOM   1782 C CB  . PHE   A 1 230 ? -8.86114  -36.56957 15.30843  1.000 23.30791 ? 230 PHE   A CB  1 
ATOM   1783 C CG  . PHE   A 1 230 ? -9.69089  -35.80545 14.31782  1.000 31.32976 ? 230 PHE   A CG  1 
ATOM   1784 C CD1 . PHE   A 1 230 ? -10.91788 -36.29943 13.89606  1.000 24.23107 ? 230 PHE   A CD1 1 
ATOM   1785 C CD2 . PHE   A 1 230 ? -9.21840  -34.62311 13.75561  1.000 34.58734 ? 230 PHE   A CD2 1 
ATOM   1786 C CE1 . PHE   A 1 230 ? -11.66114 -35.61376 12.96695  1.000 17.48824 ? 230 PHE   A CE1 1 
ATOM   1787 C CE2 . PHE   A 1 230 ? -9.96304  -33.94176 12.82066  1.000 25.58420 ? 230 PHE   A CE2 1 
ATOM   1788 C CZ  . PHE   A 1 230 ? -11.18486 -34.43948 12.42987  1.000 15.17625 ? 230 PHE   A CZ  1 
ATOM   1789 N N   . ASN   A 1 231 ? -6.10628  -36.78221 13.55849  1.000 27.14672 ? 231 ASN   A N   1 
ATOM   1790 C CA  . ASN   A 1 231 ? -5.37781  -36.33203 12.37894  1.000 23.66218 ? 231 ASN   A CA  1 
ATOM   1791 C C   . ASN   A 1 231 ? -4.99552  -37.50468 11.47293  1.000 22.11224 ? 231 ASN   A C   1 
ATOM   1792 O O   . ASN   A 1 231 ? -4.82929  -37.31923 10.26137  1.000 28.00608 ? 231 ASN   A O   1 
ATOM   1793 C CB  . ASN   A 1 231 ? -4.15284  -35.52345 12.81583  1.000 23.59127 ? 231 ASN   A CB  1 
ATOM   1794 C CG  . ASN   A 1 231 ? -4.50085  -34.07893 13.17513  1.000 22.89939 ? 231 ASN   A CG  1 
ATOM   1795 O OD1 . ASN   A 1 231 ? -5.23519  -33.40498 12.44544  1.000 22.35410 ? 231 ASN   A OD1 1 
ATOM   1796 N ND2 . ASN   A 1 231 ? -3.99987  -33.60979 14.32411  1.000 17.23703 ? 231 ASN   A ND2 1 
ATOM   1797 N N   . LEU   A 1 232 ? -4.86314  -38.71472 12.02650  1.000 22.79301 ? 232 LEU   A N   1 
ATOM   1798 C CA  . LEU   A 1 232 ? -4.64500  -39.88103 11.17356  1.000 29.92916 ? 232 LEU   A CA  1 
ATOM   1799 C C   . LEU   A 1 232 ? -5.79971  -40.09964 10.21484  1.000 27.80598 ? 232 LEU   A C   1 
ATOM   1800 O O   . LEU   A 1 232 ? -5.58907  -40.55939 9.08648   1.000 24.95770 ? 232 LEU   A O   1 
ATOM   1801 C CB  . LEU   A 1 232 ? -4.43336  -41.14560 12.01245  1.000 31.31010 ? 232 LEU   A CB  1 
ATOM   1802 C CG  . LEU   A 1 232 ? -3.00512  -41.46041 12.45922  1.000 34.15316 ? 232 LEU   A CG  1 
ATOM   1803 C CD1 . LEU   A 1 232 ? -3.01146  -42.65263 13.38095  1.000 25.02174 ? 232 LEU   A CD1 1 
ATOM   1804 C CD2 . LEU   A 1 232 ? -2.11603  -41.74609 11.25531  1.000 29.19856 ? 232 LEU   A CD2 1 
ATOM   1805 N N   . VAL   A 1 233 ? -7.02308  -39.79000 10.64781  1.000 31.65844 ? 233 VAL   A N   1 
ATOM   1806 C CA  . VAL   A 1 233 ? -8.19789  -40.02086 9.81543   1.000 20.84902 ? 233 VAL   A CA  1 
ATOM   1807 C C   . VAL   A 1 233 ? -8.41728  -38.86244 8.84304   1.000 27.26558 ? 233 VAL   A C   1 
ATOM   1808 O O   . VAL   A 1 233 ? -8.77800  -39.07765 7.67898   1.000 28.23319 ? 233 VAL   A O   1 
ATOM   1809 C CB  . VAL   A 1 233 ? -9.41673  -40.27339 10.72001  1.000 26.62332 ? 233 VAL   A CB  1 
ATOM   1810 C CG1 . VAL   A 1 233 ? -10.68663 -40.47593 9.88950   1.000 28.52176 ? 233 VAL   A CG1 1 
ATOM   1811 C CG2 . VAL   A 1 233 ? -9.14745  -41.48831 11.59801  1.000 21.58471 ? 233 VAL   A CG2 1 
ATOM   1812 N N   . ALA   A 1 234 ? -8.19529  -37.61935 9.29010   1.000 27.63816 ? 234 ALA   A N   1 
ATOM   1813 C CA  . ALA   A 1 234 ? -8.33225  -36.47908 8.38556   1.000 23.61019 ? 234 ALA   A CA  1 
ATOM   1814 C C   . ALA   A 1 234 ? -7.29308  -36.52054 7.27607   1.000 20.16879 ? 234 ALA   A C   1 
ATOM   1815 O O   . ALA   A 1 234 ? -7.57782  -36.11405 6.14637   1.000 22.10056 ? 234 ALA   A O   1 
ATOM   1816 C CB  . ALA   A 1 234 ? -8.22434  -35.16773 9.15656   1.000 27.78948 ? 234 ALA   A CB  1 
ATOM   1817 N N   . MET   A 1 235 ? -6.09226  -37.01094 7.57607   1.000 23.87914 ? 235 MET   A N   1 
ATOM   1818 C CA  . MET   A 1 235 ? -5.09202  -37.21109 6.53406   1.000 25.78428 ? 235 MET   A CA  1 
ATOM   1819 C C   . MET   A 1 235 ? -5.62143  -38.11721 5.42404   1.000 20.86243 ? 235 MET   A C   1 
ATOM   1820 O O   . MET   A 1 235 ? -5.45113  -37.81932 4.23790   1.000 18.02675 ? 235 MET   A O   1 
ATOM   1821 C CB  . MET   A 1 235 ? -3.80936  -37.77975 7.15401   1.000 22.64431 ? 235 MET   A CB  1 
ATOM   1822 C CG  . MET   A 1 235 ? -2.69835  -38.03150 6.15403   1.000 29.59283 ? 235 MET   A CG  1 
ATOM   1823 S SD  . MET   A 1 235 ? -1.09918  -38.30173 6.93801   1.000 45.32099 ? 235 MET   A SD  1 
ATOM   1824 C CE  . MET   A 1 235 ? -0.40563  -36.65076 6.89237   1.000 25.08525 ? 235 MET   A CE  1 
ATOM   1825 N N   . LYS   A 1 236 ? -6.29863  -39.20826 5.78959   1.000 23.80325 ? 236 LYS   A N   1 
ATOM   1826 C CA  . LYS   A 1 236 ? -6.77783  -40.16713 4.80573   1.000 25.91127 ? 236 LYS   A CA  1 
ATOM   1827 C C   . LYS   A 1 236 ? -8.06744  -39.74327 4.12006   1.000 25.46963 ? 236 LYS   A C   1 
ATOM   1828 O O   . LYS   A 1 236 ? -8.45326  -40.38074 3.13857   1.000 27.42810 ? 236 LYS   A O   1 
ATOM   1829 C CB  . LYS   A 1 236 ? -6.97296  -41.53256 5.45306   1.000 26.05074 ? 236 LYS   A CB  1 
ATOM   1830 C CG  . LYS   A 1 236 ? -5.69940  -42.05358 6.10349   1.000 40.28839 ? 236 LYS   A CG  1 
ATOM   1831 C CD  . LYS   A 1 236 ? -4.49657  -41.92881 5.16100   1.000 35.54925 ? 236 LYS   A CD  1 
ATOM   1832 C CE  . LYS   A 1 236 ? -3.27390  -42.65254 5.71927   1.000 29.94653 ? 236 LYS   A CE  1 
ATOM   1833 N NZ  . LYS   A 1 236 ? -2.48519  -41.77219 6.62953   1.000 32.79267 ? 236 LYS   A NZ  1 
ATOM   1834 N N   . TYR   A 1 237 ? -8.74938  -38.69864 4.59003   1.000 29.06151 ? 237 TYR   A N   1 
ATOM   1835 C CA  . TYR   A 1 237 ? -9.89955  -38.16514 3.86310   1.000 33.99781 ? 237 TYR   A CA  1 
ATOM   1836 C C   . TYR   A 1 237 ? -9.63076  -36.77431 3.29854   1.000 22.44021 ? 237 TYR   A C   1 
ATOM   1837 O O   . TYR   A 1 237 ? -10.56688 -36.01795 3.04229   1.000 30.53673 ? 237 TYR   A O   1 
ATOM   1838 C CB  . TYR   A 1 237 ? -11.15587 -38.16196 4.73362   1.000 26.35141 ? 237 TYR   A CB  1 
ATOM   1839 C CG  . TYR   A 1 237 ? -11.73711 -39.54458 4.91760   1.000 33.29327 ? 237 TYR   A CG  1 
ATOM   1840 C CD1 . TYR   A 1 237 ? -11.30787 -40.36667 5.95613   1.000 27.47713 ? 237 TYR   A CD1 1 
ATOM   1841 C CD2 . TYR   A 1 237 ? -12.70916 -40.03842 4.03996   1.000 32.53620 ? 237 TYR   A CD2 1 
ATOM   1842 C CE1 . TYR   A 1 237 ? -11.83191 -41.63888 6.12111   1.000 29.31141 ? 237 TYR   A CE1 1 
ATOM   1843 C CE2 . TYR   A 1 237 ? -13.24035 -41.31541 4.20156   1.000 32.29420 ? 237 TYR   A CE2 1 
ATOM   1844 C CZ  . TYR   A 1 237 ? -12.79221 -42.10570 5.24312   1.000 28.03566 ? 237 TYR   A CZ  1 
ATOM   1845 O OH  . TYR   A 1 237 ? -13.30771 -43.36406 5.40667   1.000 38.79672 ? 237 TYR   A OH  1 
ATOM   1846 N N   . ASN   A 1 238 ? -8.35986  -36.44631 3.06904   1.000 18.62695 ? 238 ASN   A N   1 
ATOM   1847 C CA  . ASN   A 1 238 ? -7.96774  -35.19687 2.41650   1.000 16.05370 ? 238 ASN   A CA  1 
ATOM   1848 C C   . ASN   A 1 238 ? -8.55806  -33.98518 3.13047   1.000 21.00892 ? 238 ASN   A C   1 
ATOM   1849 O O   . ASN   A 1 238 ? -9.06406  -33.05330 2.50477   1.000 14.67004 ? 238 ASN   A O   1 
ATOM   1850 C CB  . ASN   A 1 238 ? -8.35217  -35.19357 0.94105   1.000 23.72135 ? 238 ASN   A CB  1 
ATOM   1851 C CG  . ASN   A 1 238 ? -7.57368  -34.16903 0.15910   1.000 27.83406 ? 238 ASN   A CG  1 
ATOM   1852 O OD1 . ASN   A 1 238 ? -6.74083  -33.47305 0.72411   1.000 23.10479 ? 238 ASN   A OD1 1 
ATOM   1853 N ND2 . ASN   A 1 238 ? -7.82218  -34.07869 -1.14438  1.000 30.73558 ? 238 ASN   A ND2 1 
ATOM   1854 N N   . TYR   A 1 239 ? -8.49498  -34.02278 4.46078   1.000 20.86455 ? 239 TYR   A N   1 
ATOM   1855 C CA  . TYR   A 1 239 ? -8.84879  -32.92692 5.34905   1.000 17.00783 ? 239 TYR   A CA  1 
ATOM   1856 C C   . TYR   A 1 239 ? -7.56609  -32.40641 5.98109   1.000 17.49872 ? 239 TYR   A C   1 
ATOM   1857 O O   . TYR   A 1 239 ? -6.72824  -33.19651 6.42555   1.000 14.12969 ? 239 TYR   A O   1 
ATOM   1858 C CB  . TYR   A 1 239 ? -9.77501  -33.41147 6.46761   1.000 18.08256 ? 239 TYR   A CB  1 
ATOM   1859 C CG  . TYR   A 1 239 ? -11.25916 -33.42151 6.20379   1.000 16.35493 ? 239 TYR   A CG  1 
ATOM   1860 C CD1 . TYR   A 1 239 ? -11.81404 -34.25383 5.24055   1.000 15.81159 ? 239 TYR   A CD1 1 
ATOM   1861 C CD2 . TYR   A 1 239 ? -12.11745 -32.63802 6.97272   1.000 18.43348 ? 239 TYR   A CD2 1 
ATOM   1862 C CE1 . TYR   A 1 239 ? -13.18945 -34.27365 5.02397   1.000 18.02838 ? 239 TYR   A CE1 1 
ATOM   1863 C CE2 . TYR   A 1 239 ? -13.48998 -32.65623 6.77252   1.000 17.31907 ? 239 TYR   A CE2 1 
ATOM   1864 C CZ  . TYR   A 1 239 ? -14.02011 -33.47800 5.80406   1.000 15.22938 ? 239 TYR   A CZ  1 
ATOM   1865 O OH  . TYR   A 1 239 ? -15.37273 -33.48348 5.58800   1.000 17.14407 ? 239 TYR   A OH  1 
ATOM   1866 N N   . GLU   A 1 240 ? -7.40981  -31.09069 6.06723   1.000 18.41776 ? 240 GLU   A N   1 
ATOM   1867 C CA  . GLU   A 1 240 ? -6.13937  -30.60323 6.57949   1.000 15.35055 ? 240 GLU   A CA  1 
ATOM   1868 C C   . GLU   A 1 240 ? -6.00206  -30.85437 8.08761   1.000 20.62402 ? 240 GLU   A C   1 
ATOM   1869 O O   . GLU   A 1 240 ? -6.98267  -31.15435 8.78090   1.000 13.90287 ? 240 GLU   A O   1 
ATOM   1870 C CB  . GLU   A 1 240 ? -5.94699  -29.13238 6.23702   1.000 17.03922 ? 240 GLU   A CB  1 
ATOM   1871 C CG  . GLU   A 1 240 ? -7.11978  -28.24081 6.38674   1.000 17.94973 ? 240 GLU   A CG  1 
ATOM   1872 C CD  . GLU   A 1 240 ? -6.87369  -26.94488 5.67047   1.000 22.31335 ? 240 GLU   A CD  1 
ATOM   1873 O OE1 . GLU   A 1 240 ? -5.91274  -26.90424 4.85556   1.000 23.81889 ? 240 GLU   A OE1 1 
ATOM   1874 O OE2 . GLU   A 1 240 ? -7.60256  -25.96818 5.93996   1.000 15.50737 ? 240 GLU   A OE2 1 
ATOM   1875 N N   . PRO   A 1 241 ? -4.77360  -30.79943 8.60737   1.000 18.05073 ? 241 PRO   A N   1 
ATOM   1876 C CA  . PRO   A 1 241 ? -4.57883  -31.01520 10.04504  1.000 26.23707 ? 241 PRO   A CA  1 
ATOM   1877 C C   . PRO   A 1 241 ? -5.32531  -29.99258 10.89128  1.000 23.35868 ? 241 PRO   A C   1 
ATOM   1878 O O   . PRO   A 1 241 ? -5.69893  -28.90009 10.44414  1.000 23.94070 ? 241 PRO   A O   1 
ATOM   1879 C CB  . PRO   A 1 241 ? -3.06365  -30.87511 10.22909  1.000 20.44435 ? 241 PRO   A CB  1 
ATOM   1880 C CG  . PRO   A 1 241 ? -2.48875  -31.16588 8.89384   1.000 24.15349 ? 241 PRO   A CG  1 
ATOM   1881 C CD  . PRO   A 1 241 ? -3.48899  -30.68472 7.88946   1.000 19.87687 ? 241 PRO   A CD  1 
ATOM   1882 N N   . LEU   A 1 242 ? -5.54948  -30.38495 12.13767  1.000 15.84986 ? 242 LEU   A N   1 
ATOM   1883 C CA  . LEU   A 1 242 ? -6.12985  -29.53891 13.16675  1.000 21.13928 ? 242 LEU   A CA  1 
ATOM   1884 C C   . LEU   A 1 242 ? -5.05221  -29.26646 14.21016  1.000 18.87313 ? 242 LEU   A C   1 
ATOM   1885 O O   . LEU   A 1 242 ? -4.34391  -30.19054 14.62151  1.000 14.99812 ? 242 LEU   A O   1 
ATOM   1886 C CB  . LEU   A 1 242 ? -7.34888  -30.23307 13.80528  1.000 20.80753 ? 242 LEU   A CB  1 
ATOM   1887 C CG  . LEU   A 1 242 ? -8.37307  -29.34590 14.51337  1.000 22.34409 ? 242 LEU   A CG  1 
ATOM   1888 C CD1 . LEU   A 1 242 ? -9.24860  -28.62360 13.47771  1.000 16.22135 ? 242 LEU   A CD1 1 
ATOM   1889 C CD2 . LEU   A 1 242 ? -9.20613  -30.15528 15.51792  1.000 24.84647 ? 242 LEU   A CD2 1 
ATOM   1890 N N   . THR   A 1 243 ? -4.92538  -28.01395 14.63726  1.000 15.17009 ? 243 THR   A N   1 
ATOM   1891 C CA  . THR   A 1 243 ? -3.91025  -27.64322 15.61497  1.000 22.71720 ? 243 THR   A CA  1 
ATOM   1892 C C   . THR   A 1 243 ? -4.55877  -27.33995 16.95136  1.000 26.96978 ? 243 THR   A C   1 
ATOM   1893 O O   . THR   A 1 243 ? -5.77514  -27.14352 17.04279  1.000 20.77218 ? 243 THR   A O   1 
ATOM   1894 C CB  . THR   A 1 243 ? -3.09134  -26.42072 15.17311  1.000 17.11988 ? 243 THR   A CB  1 
ATOM   1895 O OG1 . THR   A 1 243 ? -3.90703  -25.24012 15.23591  1.000 17.13020 ? 243 THR   A OG1 1 
ATOM   1896 C CG2 . THR   A 1 243 ? -2.55008  -26.60835 13.77673  1.000 23.36719 ? 243 THR   A CG2 1 
ATOM   1897 N N   . GLN   A 1 244 ? -3.70498  -27.29178 17.98546  1.000 20.31887 ? 244 GLN   A N   1 
ATOM   1898 C CA  . GLN   A 1 244 ? -4.10979  -26.76286 19.28342  1.000 21.26786 ? 244 GLN   A CA  1 
ATOM   1899 C C   . GLN   A 1 244 ? -4.66246  -25.34160 19.17500  1.000 19.79498 ? 244 GLN   A C   1 
ATOM   1900 O O   . GLN   A 1 244 ? -5.47243  -24.92300 20.01142  1.000 22.19068 ? 244 GLN   A O   1 
ATOM   1901 C CB  . GLN   A 1 244 ? -2.92327  -26.79953 20.25795  1.000 24.62301 ? 244 GLN   A CB  1 
ATOM   1902 C CG  . GLN   A 1 244 ? -3.28999  -26.49875 21.71907  1.000 22.57806 ? 244 GLN   A CG  1 
ATOM   1903 C CD  . GLN   A 1 244 ? -4.39030  -27.41893 22.24716  1.000 19.88775 ? 244 GLN   A CD  1 
ATOM   1904 O OE1 . GLN   A 1 244 ? -4.28812  -28.63647 22.14735  1.000 25.57323 ? 244 GLN   A OE1 1 
ATOM   1905 N NE2 . GLN   A 1 244 ? -5.45070  -26.83623 22.79336  1.000 26.38426 ? 244 GLN   A NE2 1 
ATOM   1906 N N   . ASP   A 1 245 ? -4.24055  -24.56973 18.17747  1.000 17.14848 ? 245 ASP   A N   1 
ATOM   1907 C CA  . ASP   A 1 245 ? -4.83568  -23.24132 18.04778  1.000 21.41209 ? 245 ASP   A CA  1 
ATOM   1908 C C   . ASP   A 1 245 ? -6.26484  -23.32846 17.51881  1.000 22.50812 ? 245 ASP   A C   1 
ATOM   1909 O O   . ASP   A 1 245 ? -7.14968  -22.61098 18.00538  1.000 20.82303 ? 245 ASP   A O   1 
ATOM   1910 C CB  . ASP   A 1 245 ? -3.98287  -22.33182 17.15972  1.000 20.29534 ? 245 ASP   A CB  1 
ATOM   1911 C CG  . ASP   A 1 245 ? -4.44089  -20.86331 17.22560  1.000 23.95092 ? 245 ASP   A CG  1 
ATOM   1912 O OD1 . ASP   A 1 245 ? -4.46092  -20.26740 18.33235  1.000 20.77611 ? 245 ASP   A OD1 1 
ATOM   1913 O OD2 . ASP   A 1 245 ? -4.81797  -20.31431 16.16638  1.000 28.94528 ? 245 ASP   A OD2 1 
ATOM   1914 N N   . HIS   A 1 246 ? -6.50710  -24.20015 16.52504  1.000 17.48022 ? 246 HIS   A N   1 
ATOM   1915 C CA  . HIS   A 1 246 ? -7.87771  -24.51560 16.11187  1.000 20.41433 ? 246 HIS   A CA  1 
ATOM   1916 C C   . HIS   A 1 246 ? -8.71670  -25.02148 17.28609  1.000 18.03853 ? 246 HIS   A C   1 
ATOM   1917 O O   . HIS   A 1 246 ? -9.91605  -24.73097 17.37887  1.000 17.86729 ? 246 HIS   A O   1 
ATOM   1918 C CB  . HIS   A 1 246 ? -7.87364  -25.57048 15.00375  1.000 16.09731 ? 246 HIS   A CB  1 
ATOM   1919 C CG  . HIS   A 1 246 ? -7.24468  -25.11736 13.72280  1.000 15.27121 ? 246 HIS   A CG  1 
ATOM   1920 N ND1 . HIS   A 1 246 ? -6.62975  -25.99418 12.84939  1.000 15.14774 ? 246 HIS   A ND1 1 
ATOM   1921 C CD2 . HIS   A 1 246 ? -7.13352  -23.88650 13.16436  1.000 12.39327 ? 246 HIS   A CD2 1 
ATOM   1922 C CE1 . HIS   A 1 246 ? -6.16579  -25.32261 11.80941  1.000 18.08433 ? 246 HIS   A CE1 1 
ATOM   1923 N NE2 . HIS   A 1 246 ? -6.46537  -24.04430 11.97044  1.000 18.82296 ? 246 HIS   A NE2 1 
ATOM   1924 N N   . VAL   A 1 247 ? -8.11742  -25.81310 18.17535  1.000 19.15630 ? 247 VAL   A N   1 
ATOM   1925 C CA  . VAL   A 1 247 ? -8.84023  -26.25909 19.36242  1.000 13.48763 ? 247 VAL   A CA  1 
ATOM   1926 C C   . VAL   A 1 247 ? -9.16286  -25.07206 20.26498  1.000 21.77627 ? 247 VAL   A C   1 
ATOM   1927 O O   . VAL   A 1 247 ? -10.31668 -24.87464 20.67005  1.000 26.11162 ? 247 VAL   A O   1 
ATOM   1928 C CB  . VAL   A 1 247 ? -8.03120  -27.33434 20.10497  1.000 18.95963 ? 247 VAL   A CB  1 
ATOM   1929 C CG1 . VAL   A 1 247 ? -8.52889  -27.46338 21.54357  1.000 17.08429 ? 247 VAL   A CG1 1 
ATOM   1930 C CG2 . VAL   A 1 247 ? -8.15131  -28.66010 19.37593  1.000 17.86370 ? 247 VAL   A CG2 1 
ATOM   1931 N N   . ASP   A 1 248 ? -8.14918  -24.25808 20.58733  1.000 19.48107 ? 248 ASP   A N   1 
ATOM   1932 C CA  . ASP   A 1 248 ? -8.37549  -23.08670 21.43535  1.000 26.34480 ? 248 ASP   A CA  1 
ATOM   1933 C C   . ASP   A 1 248 ? -9.39879  -22.13282 20.82565  1.000 25.05300 ? 248 ASP   A C   1 
ATOM   1934 O O   . ASP   A 1 248 ? -10.09598 -21.41988 21.56018  1.000 26.80128 ? 248 ASP   A O   1 
ATOM   1935 C CB  . ASP   A 1 248 ? -7.05637  -22.34086 21.68875  1.000 25.00123 ? 248 ASP   A CB  1 
ATOM   1936 C CG  . ASP   A 1 248 ? -6.00606  -23.20513 22.37564  1.000 23.88163 ? 248 ASP   A CG  1 
ATOM   1937 O OD1 . ASP   A 1 248 ? -6.38184  -24.19202 23.04881  1.000 18.27792 ? 248 ASP   A OD1 1 
ATOM   1938 O OD2 . ASP   A 1 248 ? -4.80200  -22.88602 22.25498  1.000 21.25926 ? 248 ASP   A OD2 1 
ATOM   1939 N N   . ILE   A 1 249 ? -9.50400  -22.10389 19.49356  1.000 19.12960 ? 249 ILE   A N   1 
ATOM   1940 C CA  . ILE   A 1 249 ? -10.41410 -21.16551 18.84789  1.000 19.55423 ? 249 ILE   A CA  1 
ATOM   1941 C C   . ILE   A 1 249 ? -11.84218 -21.67818 18.93796  1.000 24.51217 ? 249 ILE   A C   1 
ATOM   1942 O O   . ILE   A 1 249 ? -12.79506 -20.88747 19.00257  1.000 23.43500 ? 249 ILE   A O   1 
ATOM   1943 C CB  . ILE   A 1 249 ? -9.97958  -20.93122 17.38911  1.000 19.24718 ? 249 ILE   A CB  1 
ATOM   1944 C CG1 . ILE   A 1 249 ? -8.82472  -19.92645 17.33052  1.000 28.26436 ? 249 ILE   A CG1 1 
ATOM   1945 C CG2 . ILE   A 1 249 ? -11.12295 -20.40031 16.54632  1.000 16.21682 ? 249 ILE   A CG2 1 
ATOM   1946 C CD1 . ILE   A 1 249 ? -7.98188  -20.04053 16.07624  1.000 10.41588 ? 249 ILE   A CD1 1 
ATOM   1947 N N   . LEU   A 1 250 ? -12.01171 -22.99819 18.96103  1.000 19.63943 ? 250 LEU   A N   1 
ATOM   1948 C CA  . LEU   A 1 250 ? -13.33070 -23.59303 19.08499  1.000 22.47429 ? 250 LEU   A CA  1 
ATOM   1949 C C   . LEU   A 1 250 ? -13.85962 -23.55702 20.51643  1.000 23.88841 ? 250 LEU   A C   1 
ATOM   1950 O O   . LEU   A 1 250 ? -15.04611 -23.85950 20.73236  1.000 15.05005 ? 250 LEU   A O   1 
ATOM   1951 C CB  . LEU   A 1 250 ? -13.29118 -25.03106 18.55584  1.000 19.24738 ? 250 LEU   A CB  1 
ATOM   1952 C CG  . LEU   A 1 250 ? -13.04706 -25.22490 17.05713  1.000 20.63721 ? 250 LEU   A CG  1 
ATOM   1953 C CD1 . LEU   A 1 250 ? -12.78909 -26.70927 16.76661  1.000 11.98992 ? 250 LEU   A CD1 1 
ATOM   1954 C CD2 . LEU   A 1 250 ? -14.18239 -24.66985 16.18879  1.000 16.94307 ? 250 LEU   A CD2 1 
ATOM   1955 N N   . GLY   A 1 251 ? -13.00908 -23.16801 21.47489  1.000 19.45526 ? 251 GLY   A N   1 
ATOM   1956 C CA  . GLY   A 1 251 ? -13.33771 -23.10870 22.88157  1.000 18.70319 ? 251 GLY   A CA  1 
ATOM   1957 C C   . GLY   A 1 251 ? -14.69380 -22.51717 23.21270  1.000 17.19623 ? 251 GLY   A C   1 
ATOM   1958 O O   . GLY   A 1 251 ? -15.50345 -23.15630 23.88715  1.000 17.78497 ? 251 GLY   A O   1 
ATOM   1959 N N   . PRO   A 1 252 ? -14.96223 -21.27958 22.76213  1.000 21.32513 ? 252 PRO   A N   1 
ATOM   1960 C CA  . PRO   A 1 252 ? -16.28751 -20.67386 23.01521  1.000 15.35992 ? 252 PRO   A CA  1 
ATOM   1961 C C   . PRO   A 1 252 ? -17.44458 -21.48323 22.45925  1.000 21.43061 ? 252 PRO   A C   1 
ATOM   1962 O O   . PRO   A 1 252 ? -18.52530 -21.51163 23.06030  1.000 19.88881 ? 252 PRO   A O   1 
ATOM   1963 C CB  . PRO   A 1 252 ? -16.20027 -19.30611 22.31893  1.000 16.38576 ? 252 PRO   A CB  1 
ATOM   1964 C CG  . PRO   A 1 252 ? -14.75747 -19.04655 22.10839  1.000 17.31505 ? 252 PRO   A CG  1 
ATOM   1965 C CD  . PRO   A 1 252 ? -14.01099 -20.33488 22.14219  1.000 15.14218 ? 252 PRO   A CD  1 
ATOM   1966 N N   . LEU   A 1 253 ? -17.26948 -22.13804 21.31488  1.000 20.99958 ? 253 LEU   A N   1 
ATOM   1967 C CA  . LEU   A 1 253 ? -18.37236 -22.93921 20.80211  1.000 22.35702 ? 253 LEU   A CA  1 
ATOM   1968 C C   . LEU   A 1 253 ? -18.51145 -24.24125 21.57720  1.000 23.41741 ? 253 LEU   A C   1 
ATOM   1969 O O   . LEU   A 1 253 ? -19.60629 -24.81472 21.64185  1.000 21.12794 ? 253 LEU   A O   1 
ATOM   1970 C CB  . LEU   A 1 253 ? -18.18204 -23.20223 19.31905  1.000 19.14602 ? 253 LEU   A CB  1 
ATOM   1971 C CG  . LEU   A 1 253 ? -18.54332 -22.11986 18.30200  1.000 13.69174 ? 253 LEU   A CG  1 
ATOM   1972 C CD1 . LEU   A 1 253 ? -18.23201 -22.67318 16.88377  1.000 8.46758  ? 253 LEU   A CD1 1 
ATOM   1973 C CD2 . LEU   A 1 253 ? -20.00515 -21.74023 18.47341  1.000 10.83732 ? 253 LEU   A CD2 1 
ATOM   1974 N N   . SER   A 1 254 ? -17.42466 -24.70016 22.19593  1.000 17.31335 ? 254 SER   A N   1 
ATOM   1975 C CA  . SER   A 1 254 ? -17.50154 -25.87965 23.04288  1.000 21.49765 ? 254 SER   A CA  1 
ATOM   1976 C C   . SER   A 1 254 ? -18.26564 -25.57272 24.33044  1.000 19.37394 ? 254 SER   A C   1 
ATOM   1977 O O   . SER   A 1 254 ? -19.05527 -26.39629 24.80826  1.000 19.47202 ? 254 SER   A O   1 
ATOM   1978 C CB  . SER   A 1 254 ? -16.07553 -26.37598 23.33396  1.000 20.74159 ? 254 SER   A CB  1 
ATOM   1979 O OG  . SER   A 1 254 ? -16.04695 -27.64254 23.96083  1.000 20.64480 ? 254 SER   A OG  1 
ATOM   1980 N N   . ALA   A 1 255 ? -18.06295 -24.37848 24.89469  1.000 22.36679 ? 255 ALA   A N   1 
ATOM   1981 C CA  . ALA   A 1 255 ? -18.64503 -24.03500 26.18845  1.000 22.62920 ? 255 ALA   A CA  1 
ATOM   1982 C C   . ALA   A 1 255 ? -20.11877 -23.65741 26.09732  1.000 26.35212 ? 255 ALA   A C   1 
ATOM   1983 O O   . ALA   A 1 255 ? -20.81789 -23.69195 27.11494  1.000 22.32623 ? 255 ALA   A O   1 
ATOM   1984 C CB  . ALA   A 1 255 ? -17.84862 -22.89282 26.83573  1.000 24.61577 ? 255 ALA   A CB  1 
ATOM   1985 N N   . GLN   A 1 256 ? -20.60083 -23.28390 24.91065  1.000 29.72200 ? 256 GLN   A N   1 
ATOM   1986 C CA  . GLN   A 1 256 ? -22.02362 -23.03132 24.71512  1.000 21.28351 ? 256 GLN   A CA  1 
ATOM   1987 C C   . GLN   A 1 256 ? -22.79954 -24.32622 24.50573  1.000 25.36406 ? 256 GLN   A C   1 
ATOM   1988 O O   . GLN   A 1 256 ? -23.96750 -24.41737 24.89790  1.000 25.16837 ? 256 GLN   A O   1 
ATOM   1989 C CB  . GLN   A 1 256 ? -22.21775 -22.10162 23.51551  1.000 25.41237 ? 256 GLN   A CB  1 
ATOM   1990 C CG  . GLN   A 1 256 ? -23.64513 -21.61939 23.27533  1.000 24.48150 ? 256 GLN   A CG  1 
ATOM   1991 C CD  . GLN   A 1 256 ? -23.79358 -20.97349 21.91062  1.000 26.85052 ? 256 GLN   A CD  1 
ATOM   1992 O OE1 . GLN   A 1 256 ? -22.87213 -21.01798 21.09831  1.000 32.44900 ? 256 GLN   A OE1 1 
ATOM   1993 N NE2 . GLN   A 1 256 ? -24.95159 -20.37996 21.64685  1.000 23.61778 ? 256 GLN   A NE2 1 
ATOM   1994 N N   . THR   A 1 257 ? -22.17528 -25.33092 23.88443  1.000 20.97239 ? 257 THR   A N   1 
ATOM   1995 C CA  . THR   A 1 257 ? -22.82914 -26.61202 23.65099  1.000 26.32765 ? 257 THR   A CA  1 
ATOM   1996 C C   . THR   A 1 257 ? -22.55956 -27.62365 24.75544  1.000 25.13135 ? 257 THR   A C   1 
ATOM   1997 O O   . THR   A 1 257 ? -23.31697 -28.58996 24.89147  1.000 27.98761 ? 257 THR   A O   1 
ATOM   1998 C CB  . THR   A 1 257 ? -22.37731 -27.21638 22.30442  1.000 23.73046 ? 257 THR   A CB  1 
ATOM   1999 O OG1 . THR   A 1 257 ? -20.93923 -27.27908 22.25053  1.000 19.15400 ? 257 THR   A OG1 1 
ATOM   2000 C CG2 . THR   A 1 257 ? -22.89718 -26.39713 21.12798  1.000 19.67854 ? 257 THR   A CG2 1 
ATOM   2001 N N   . GLY   A 1 258 ? -21.51107 -27.42324 25.54692  1.000 24.31179 ? 258 GLY   A N   1 
ATOM   2002 C CA  . GLY   A 1 258 ? -21.06745 -28.47495 26.43412  1.000 23.15963 ? 258 GLY   A CA  1 
ATOM   2003 C C   . GLY   A 1 258 ? -20.51660 -29.69569 25.72959  1.000 20.48659 ? 258 GLY   A C   1 
ATOM   2004 O O   . GLY   A 1 258 ? -20.48892 -30.77688 26.32178  1.000 14.47592 ? 258 GLY   A O   1 
ATOM   2005 N N   . ILE   A 1 259 ? -20.08826 -29.56122 24.47252  1.000 23.83442 ? 259 ILE   A N   1 
ATOM   2006 C CA  . ILE   A 1 259 ? -19.47522 -30.65277 23.71736  1.000 21.35353 ? 259 ILE   A CA  1 
ATOM   2007 C C   . ILE   A 1 259 ? -17.99060 -30.32712 23.57591  1.000 20.00004 ? 259 ILE   A C   1 
ATOM   2008 O O   . ILE   A 1 259 ? -17.60338 -29.46199 22.78273  1.000 17.58676 ? 259 ILE   A O   1 
ATOM   2009 C CB  . ILE   A 1 259 ? -20.15153 -30.86166 22.35678  1.000 18.96367 ? 259 ILE   A CB  1 
ATOM   2010 C CG1 . ILE   A 1 259 ? -21.64169 -31.11485 22.56715  1.000 16.07236 ? 259 ILE   A CG1 1 
ATOM   2011 C CG2 . ILE   A 1 259 ? -19.55661 -32.07480 21.65360  1.000 16.84731 ? 259 ILE   A CG2 1 
ATOM   2012 C CD1 . ILE   A 1 259 ? -22.49483 -30.71679 21.42189  1.000 15.26823 ? 259 ILE   A CD1 1 
ATOM   2013 N N   . ALA   A 1 260 ? -17.16020 -30.99415 24.38050  1.000 16.70536 ? 260 ALA   A N   1 
ATOM   2014 C CA  . ALA   A 1 260 ? -15.71550 -30.82608 24.29731  1.000 17.60898 ? 260 ALA   A CA  1 
ATOM   2015 C C   . ALA   A 1 260 ? -15.24293 -30.96054 22.85676  1.000 23.62427 ? 260 ALA   A C   1 
ATOM   2016 O O   . ALA   A 1 260 ? -15.76750 -31.77291 22.08905  1.000 19.76398 ? 260 ALA   A O   1 
ATOM   2017 C CB  . ALA   A 1 260 ? -15.00374 -31.86056 25.17196  1.000 25.95154 ? 260 ALA   A CB  1 
ATOM   2018 N N   . VAL   A 1 261 ? -14.23237 -30.15732 22.50423  1.000 27.32626 ? 261 VAL   A N   1 
ATOM   2019 C CA  . VAL   A 1 261 ? -13.79016 -30.05867 21.11526  1.000 21.68070 ? 261 VAL   A CA  1 
ATOM   2020 C C   . VAL   A 1 261 ? -13.37897 -31.42627 20.58164  1.000 21.79294 ? 261 VAL   A C   1 
ATOM   2021 O O   . VAL   A 1 261 ? -13.75059 -31.80983 19.46589  1.000 21.79050 ? 261 VAL   A O   1 
ATOM   2022 C CB  . VAL   A 1 261 ? -12.65863 -29.01871 20.99223  1.000 20.94892 ? 261 VAL   A CB  1 
ATOM   2023 C CG1 . VAL   A 1 261 ? -12.12488 -28.96101 19.56620  1.000 16.90179 ? 261 VAL   A CG1 1 
ATOM   2024 C CG2 . VAL   A 1 261 ? -13.15695 -27.63073 21.42913  1.000 18.38625 ? 261 VAL   A CG2 1 
ATOM   2025 N N   . LEU   A 1 262 ? -12.62485 -32.19085 21.37203  1.000 19.54346 ? 262 LEU   A N   1 
ATOM   2026 C CA  . LEU   A 1 262 ? -12.21899 -33.52755 20.94850  1.000 21.09895 ? 262 LEU   A CA  1 
ATOM   2027 C C   . LEU   A 1 262 ? -13.39718 -34.48587 20.82262  1.000 19.64181 ? 262 LEU   A C   1 
ATOM   2028 O O   . LEU   A 1 262 ? -13.30009 -35.45946 20.07302  1.000 26.90309 ? 262 LEU   A O   1 
ATOM   2029 C CB  . LEU   A 1 262 ? -11.19659 -34.12920 21.92303  1.000 14.41203 ? 262 LEU   A CB  1 
ATOM   2030 C CG  . LEU   A 1 262 ? -9.71011  -33.76113 21.85693  1.000 23.13717 ? 262 LEU   A CG  1 
ATOM   2031 C CD1 . LEU   A 1 262 ? -9.10802  -34.10052 20.49582  1.000 23.26932 ? 262 LEU   A CD1 1 
ATOM   2032 C CD2 . LEU   A 1 262 ? -9.42661  -32.32108 22.26219  1.000 19.34185 ? 262 LEU   A CD2 1 
ATOM   2033 N N   . ASP   A 1 263 ? -14.48605 -34.26560 21.56279  1.000 18.14447 ? 263 ASP   A N   1 
ATOM   2034 C CA  . ASP   A 1 263 ? -15.67609 -35.09046 21.37147  1.000 23.20875 ? 263 ASP   A CA  1 
ATOM   2035 C C   . ASP   A 1 263 ? -16.28604 -34.85428 19.99294  1.000 22.74045 ? 263 ASP   A C   1 
ATOM   2036 O O   . ASP   A 1 263 ? -16.72641 -35.79957 19.32249  1.000 12.69562 ? 263 ASP   A O   1 
ATOM   2037 C CB  . ASP   A 1 263 ? -16.71187 -34.80723 22.46675  1.000 27.36299 ? 263 ASP   A CB  1 
ATOM   2038 C CG  . ASP   A 1 263 ? -16.28790 -35.31759 23.83740  1.000 32.22445 ? 263 ASP   A CG  1 
ATOM   2039 O OD1 . ASP   A 1 263 ? -15.40339 -36.20862 23.91239  1.000 27.85584 ? 263 ASP   A OD1 1 
ATOM   2040 O OD2 . ASP   A 1 263 ? -16.85870 -34.82474 24.84020  1.000 31.34739 ? 263 ASP   A OD2 1 
ATOM   2041 N N   . MET   A 1 264 ? -16.30725 -33.59860 19.54399  1.000 19.67799 ? 264 MET   A N   1 
ATOM   2042 C CA  . MET   A 1 264 ? -16.84619 -33.32138 18.22144  1.000 18.67968 ? 264 MET   A CA  1 
ATOM   2043 C C   . MET   A 1 264 ? -15.95237 -33.88179 17.11313  1.000 23.02493 ? 264 MET   A C   1 
ATOM   2044 O O   . MET   A 1 264 ? -16.45905 -34.22149 16.03411  1.000 15.35478 ? 264 MET   A O   1 
ATOM   2045 C CB  . MET   A 1 264 ? -17.05878 -31.82051 18.04901  1.000 20.15516 ? 264 MET   A CB  1 
ATOM   2046 C CG  . MET   A 1 264 ? -17.90636 -31.47735 16.85398  1.000 21.77084 ? 264 MET   A CG  1 
ATOM   2047 S SD  . MET   A 1 264 ? -19.63406 -31.98316 17.01354  1.000 12.44291 ? 264 MET   A SD  1 
ATOM   2048 C CE  . MET   A 1 264 ? -20.33037 -30.60529 17.96129  1.000 8.93092  ? 264 MET   A CE  1 
ATOM   2049 N N   . CYS   A 1 265 ? -14.63198 -33.99898 17.35854  1.000 21.48907 ? 265 CYS   A N   1 
ATOM   2050 C CA  . CYS   A 1 265 ? -13.75811 -34.65096 16.38340  1.000 16.82238 ? 265 CYS   A CA  1 
ATOM   2051 C C   . CYS   A 1 265 ? -14.09816 -36.12880 16.21927  1.000 18.91318 ? 265 CYS   A C   1 
ATOM   2052 O O   . CYS   A 1 265 ? -14.03222 -36.66046 15.10198  1.000 16.56565 ? 265 CYS   A O   1 
ATOM   2053 C CB  . CYS   A 1 265 ? -12.27746 -34.49255 16.77441  1.000 19.89050 ? 265 CYS   A CB  1 
ATOM   2054 S SG  . CYS   A 1 265 ? -11.67225 -32.79068 16.97119  1.000 17.41678 ? 265 CYS   A SG  1 
ATOM   2055 N N   . ALA   A 1 266 ? -14.45384 -36.81447 17.31169  1.000 24.11013 ? 266 ALA   A N   1 
ATOM   2056 C CA  . ALA   A 1 266 ? -14.90486 -38.19745 17.18648  1.000 18.96014 ? 266 ALA   A CA  1 
ATOM   2057 C C   . ALA   A 1 266 ? -16.18402 -38.28500 16.36353  1.000 23.88119 ? 266 ALA   A C   1 
ATOM   2058 O O   . ALA   A 1 266 ? -16.33718 -39.20779 15.55235  1.000 23.30498 ? 266 ALA   A O   1 
ATOM   2059 C CB  . ALA   A 1 266 ? -15.10769 -38.83567 18.55838  1.000 21.11833 ? 266 ALA   A CB  1 
ATOM   2060 N N   . SER   A 1 267 ? -17.11435 -37.33402 16.55166  1.000 19.77397 ? 267 SER   A N   1 
ATOM   2061 C CA  . SER   A 1 267 ? -18.27071 -37.24929 15.65632  1.000 22.94544 ? 267 SER   A CA  1 
ATOM   2062 C C   . SER   A 1 267 ? -17.81678 -37.15298 14.20943  1.000 25.52811 ? 267 SER   A C   1 
ATOM   2063 O O   . SER   A 1 267 ? -18.19735 -37.97368 13.36904  1.000 25.44706 ? 267 SER   A O   1 
ATOM   2064 C CB  . SER   A 1 267 ? -19.15399 -36.04482 15.99972  1.000 23.51570 ? 267 SER   A CB  1 
ATOM   2065 O OG  . SER   A 1 267 ? -19.88246 -36.23250 17.19431  1.000 24.94220 ? 267 SER   A OG  1 
ATOM   2066 N N   . LEU   A 1 268 ? -16.97578 -36.15569 13.91162  1.000 23.31912 ? 268 LEU   A N   1 
ATOM   2067 C CA  . LEU   A 1 268 ? -16.48253 -35.96283 12.55014  1.000 23.99312 ? 268 LEU   A CA  1 
ATOM   2068 C C   . LEU   A 1 268 ? -15.75335 -37.19417 12.02999  1.000 22.28347 ? 268 LEU   A C   1 
ATOM   2069 O O   . LEU   A 1 268 ? -15.83346 -37.50865 10.83614  1.000 18.89229 ? 268 LEU   A O   1 
ATOM   2070 C CB  . LEU   A 1 268 ? -15.56546 -34.74294 12.50427  1.000 17.68872 ? 268 LEU   A CB  1 
ATOM   2071 C CG  . LEU   A 1 268 ? -15.14318 -34.28496 11.12026  1.000 19.51538 ? 268 LEU   A CG  1 
ATOM   2072 C CD1 . LEU   A 1 268 ? -16.36119 -34.21583 10.18715  1.000 19.38852 ? 268 LEU   A CD1 1 
ATOM   2073 C CD2 . LEU   A 1 268 ? -14.45422 -32.93814 11.24969  1.000 23.13179 ? 268 LEU   A CD2 1 
ATOM   2074 N N   . LYS   A 1 269 ? -15.02715 -37.89791 12.90773  1.000 21.39872 ? 269 LYS   A N   1 
ATOM   2075 C CA  . LYS   A 1 269 ? -14.38640 -39.14561 12.50095  1.000 25.63253 ? 269 LYS   A CA  1 
ATOM   2076 C C   . LYS   A 1 269 ? -15.40957 -40.13854 11.95384  1.000 28.80582 ? 269 LYS   A C   1 
ATOM   2077 O O   . LYS   A 1 269 ? -15.18862 -40.75685 10.90568  1.000 25.48411 ? 269 LYS   A O   1 
ATOM   2078 C CB  . LYS   A 1 269 ? -13.60700 -39.75912 13.66753  1.000 26.05319 ? 269 LYS   A CB  1 
ATOM   2079 C CG  . LYS   A 1 269 ? -12.86627 -41.04126 13.27670  1.000 31.26333 ? 269 LYS   A CG  1 
ATOM   2080 C CD  . LYS   A 1 269 ? -11.58614 -41.25263 14.07888  1.000 35.31580 ? 269 LYS   A CD  1 
ATOM   2081 C CE  . LYS   A 1 269 ? -11.84303 -41.90707 15.42799  1.000 37.27989 ? 269 LYS   A CE  1 
ATOM   2082 N NZ  . LYS   A 1 269 ? -10.57412 -42.26259 16.12579  1.000 32.42133 ? 269 LYS   A NZ  1 
ATOM   2083 N N   . GLU   A 1 270 ? -16.55114 -40.28900 12.64126  1.000 27.38082 ? 270 GLU   A N   1 
ATOM   2084 C CA  . GLU   A 1 270 ? -17.55097 -41.26056 12.19872  1.000 33.81865 ? 270 GLU   A CA  1 
ATOM   2085 C C   . GLU   A 1 270 ? -18.29263 -40.78627 10.95127  1.000 28.27426 ? 270 GLU   A C   1 
ATOM   2086 O O   . GLU   A 1 270 ? -18.60159 -41.59422 10.06692  1.000 27.40554 ? 270 GLU   A O   1 
ATOM   2087 C CB  . GLU   A 1 270 ? -18.53493 -41.57304 13.32962  1.000 25.37245 ? 270 GLU   A CB  1 
ATOM   2088 C CG  . GLU   A 1 270 ? -17.86984 -41.95027 14.62472  1.000 30.71116 ? 270 GLU   A CG  1 
ATOM   2089 C CD  . GLU   A 1 270 ? -17.35076 -43.38247 14.63774  1.000 36.17236 ? 270 GLU   A CD  1 
ATOM   2090 O OE1 . GLU   A 1 270 ? -16.61026 -43.72843 15.58331  1.000 40.08366 ? 270 GLU   A OE1 1 
ATOM   2091 O OE2 . GLU   A 1 270 ? -17.69127 -44.16383 13.72224  1.000 28.19080 ? 270 GLU   A OE2 1 
ATOM   2092 N N   . LEU   A 1 271 ? -18.60776 -39.49105 10.86201  1.000 21.24838 ? 271 LEU   A N   1 
ATOM   2093 C CA  . LEU   A 1 271 ? -19.23189 -38.99638 9.63940   1.000 26.24131 ? 271 LEU   A CA  1 
ATOM   2094 C C   . LEU   A 1 271 ? -18.36362 -39.31230 8.42235   1.000 26.62728 ? 271 LEU   A C   1 
ATOM   2095 O O   . LEU   A 1 271 ? -18.86842 -39.77565 7.39277   1.000 23.08162 ? 271 LEU   A O   1 
ATOM   2096 C CB  . LEU   A 1 271 ? -19.49236 -37.49368 9.74926   1.000 25.23444 ? 271 LEU   A CB  1 
ATOM   2097 C CG  . LEU   A 1 271 ? -20.41420 -37.08831 10.90622  1.000 22.70420 ? 271 LEU   A CG  1 
ATOM   2098 C CD1 . LEU   A 1 271 ? -20.34700 -35.58319 11.13939  1.000 26.62969 ? 271 LEU   A CD1 1 
ATOM   2099 C CD2 . LEU   A 1 271 ? -21.84450 -37.53831 10.66761  1.000 25.17130 ? 271 LEU   A CD2 1 
ATOM   2100 N N   . LEU   A 1 272 ? -17.04415 -39.12990 8.55026   1.000 29.37115 ? 272 LEU   A N   1 
ATOM   2101 C CA  . LEU   A 1 272 ? -16.13565 -39.35625 7.42778   1.000 24.03840 ? 272 LEU   A CA  1 
ATOM   2102 C C   . LEU   A 1 272 ? -16.11423 -40.81500 6.99086   1.000 27.28736 ? 272 LEU   A C   1 
ATOM   2103 O O   . LEU   A 1 272 ? -15.98488 -41.09979 5.79661   1.000 25.76616 ? 272 LEU   A O   1 
ATOM   2104 C CB  . LEU   A 1 272 ? -14.72587 -38.91144 7.79947   1.000 26.30737 ? 272 LEU   A CB  1 
ATOM   2105 C CG  . LEU   A 1 272 ? -14.52348 -37.40807 7.81576   1.000 25.58945 ? 272 LEU   A CG  1 
ATOM   2106 C CD1 . LEU   A 1 272 ? -13.07048 -37.09661 8.11903   1.000 27.51683 ? 272 LEU   A CD1 1 
ATOM   2107 C CD2 . LEU   A 1 272 ? -14.95522 -36.83855 6.47872   1.000 14.68451 ? 272 LEU   A CD2 1 
ATOM   2108 N N   . GLN   A 1 273 ? -16.21999 -41.74711 7.94194   1.000 28.26481 ? 273 GLN   A N   1 
ATOM   2109 C CA  . GLN   A 1 273 ? -16.08464 -43.17787 7.68451   1.000 33.46624 ? 273 GLN   A CA  1 
ATOM   2110 C C   . GLN   A 1 273 ? -17.40746 -43.83863 7.33038   1.000 34.77992 ? 273 GLN   A C   1 
ATOM   2111 O O   . GLN   A 1 273 ? -17.46057 -44.64408 6.39429   1.000 31.71178 ? 273 GLN   A O   1 
ATOM   2112 C CB  . GLN   A 1 273 ? -15.47530 -43.88372 8.90545   1.000 30.62803 ? 273 GLN   A CB  1 
ATOM   2113 C CG  . GLN   A 1 273 ? -14.18770 -43.24866 9.40798   1.000 34.26503 ? 273 GLN   A CG  1 
ATOM   2114 C CD  . GLN   A 1 273 ? -13.39477 -44.15334 10.33087  1.000 45.01537 ? 273 GLN   A CD  1 
ATOM   2115 O OE1 . GLN   A 1 273 ? -13.83845 -44.47602 11.43505  1.000 45.34799 ? 273 GLN   A OE1 1 
ATOM   2116 N NE2 . GLN   A 1 273 ? -12.20494 -44.55419 9.89023   1.000 46.48195 ? 273 GLN   A NE2 1 
ATOM   2117 N N   . ASN   A 1 274 ? -18.47525 -43.51756 8.06479   1.000 30.56032 ? 274 ASN   A N   1 
ATOM   2118 C CA  . ASN   A 1 274 ? -19.76708 -44.16725 7.88503   1.000 35.89995 ? 274 ASN   A CA  1 
ATOM   2119 C C   . ASN   A 1 274 ? -20.69176 -43.40518 6.94398   1.000 37.43704 ? 274 ASN   A C   1 
ATOM   2120 O O   . ASN   A 1 274 ? -21.73732 -43.94114 6.55195   1.000 36.39870 ? 274 ASN   A O   1 
ATOM   2121 C CB  . ASN   A 1 274 ? -20.46020 -44.35689 9.24753   1.000 36.64023 ? 274 ASN   A CB  1 
ATOM   2122 C CG  . ASN   A 1 274 ? -19.56730 -45.06145 10.27186  1.000 43.28402 ? 274 ASN   A CG  1 
ATOM   2123 O OD1 . ASN   A 1 274 ? -19.04810 -44.43481 11.19920  1.000 43.04500 ? 274 ASN   A OD1 1 
ATOM   2124 N ND2 . ASN   A 1 274 ? -19.38522 -46.36793 10.10417  1.000 48.74870 ? 274 ASN   A ND2 1 
ATOM   2125 N N   . GLY   A 1 275 ? -20.32754 -42.18965 6.55017   1.000 37.99375 ? 275 GLY   A N   1 
ATOM   2126 C CA  . GLY   A 1 275 ? -21.22758 -41.38028 5.76440   1.000 26.67888 ? 275 GLY   A CA  1 
ATOM   2127 C C   . GLY   A 1 275 ? -22.30002 -40.78113 6.64880   1.000 27.10370 ? 275 GLY   A C   1 
ATOM   2128 O O   . GLY   A 1 275 ? -22.22130 -40.80490 7.87382   1.000 24.51472 ? 275 GLY   A O   1 
ATOM   2129 N N   . MET   A 1 276 ? -23.32836 -40.23318 6.00321   1.000 38.88371 ? 276 MET   A N   1 
ATOM   2130 C CA  . MET   A 1 276 ? -24.43354 -39.61908 6.72320   1.000 33.96305 ? 276 MET   A CA  1 
ATOM   2131 C C   . MET   A 1 276 ? -25.68632 -40.47908 6.74270   1.000 32.17628 ? 276 MET   A C   1 
ATOM   2132 O O   . MET   A 1 276 ? -26.60512 -40.17484 7.50532   1.000 32.52220 ? 276 MET   A O   1 
ATOM   2133 C CB  . MET   A 1 276 ? -24.77078 -38.24714 6.12762   1.000 37.65476 ? 276 MET   A CB  1 
ATOM   2134 C CG  . MET   A 1 276 ? -23.73844 -37.16258 6.40074   1.000 37.33920 ? 276 MET   A CG  1 
ATOM   2135 S SD  . MET   A 1 276 ? -24.26023 -35.64719 5.59190   1.000 38.73695 ? 276 MET   A SD  1 
ATOM   2136 C CE  . MET   A 1 276 ? -25.71314 -35.30565 6.54593   1.000 30.02834 ? 276 MET   A CE  1 
ATOM   2137 N N   . ASN   A 1 277 ? -25.74581 -41.53474 5.92608   1.000 32.84042 ? 277 ASN   A N   1 
ATOM   2138 C CA  . ASN   A 1 277 ? -26.73904 -42.59899 6.06501   1.000 30.62471 ? 277 ASN   A CA  1 
ATOM   2139 C C   . ASN   A 1 277 ? -28.14888 -42.10473 5.74078   1.000 36.52157 ? 277 ASN   A C   1 
ATOM   2140 O O   . ASN   A 1 277 ? -29.10781 -42.43325 6.44438   1.000 29.78361 ? 277 ASN   A O   1 
ATOM   2141 C CB  . ASN   A 1 277 ? -26.69586 -43.21276 7.47033   1.000 40.00084 ? 277 ASN   A CB  1 
ATOM   2142 C CG  . ASN   A 1 277 ? -25.27495 -43.49072 7.95488   1.000 33.91301 ? 277 ASN   A CG  1 
ATOM   2143 O OD1 . ASN   A 1 277 ? -24.68514 -44.51641 7.61983   1.000 33.60960 ? 277 ASN   A OD1 1 
ATOM   2144 N ND2 . ASN   A 1 277 ? -24.71320 -42.55637 8.72772   1.000 30.04721 ? 277 ASN   A ND2 1 
ATOM   2145 N N   . GLY   A 1 278 ? -28.27306 -41.30073 4.68051   1.000 35.02881 ? 278 GLY   A N   1 
ATOM   2146 C CA  . GLY   A 1 278 ? -29.55648 -40.79237 4.23490   1.000 26.99829 ? 278 GLY   A CA  1 
ATOM   2147 C C   . GLY   A 1 278 ? -30.12663 -39.62972 5.02459   1.000 32.85795 ? 278 GLY   A C   1 
ATOM   2148 O O   . GLY   A 1 278 ? -31.25050 -39.19803 4.72858   1.000 36.09798 ? 278 GLY   A O   1 
ATOM   2149 N N   . ARG   A 1 279 ? -29.40705 -39.11164 6.01880   1.000 32.07726 ? 279 ARG   A N   1 
ATOM   2150 C CA  . ARG   A 1 279 ? -29.85885 -37.97163 6.80789   1.000 31.47664 ? 279 ARG   A CA  1 
ATOM   2151 C C   . ARG   A 1 279 ? -29.23061 -36.69002 6.26159   1.000 25.75532 ? 279 ARG   A C   1 
ATOM   2152 O O   . ARG   A 1 279 ? -28.49513 -36.70897 5.27116   1.000 26.25528 ? 279 ARG   A O   1 
ATOM   2153 C CB  . ARG   A 1 279 ? -29.51803 -38.16712 8.29005   1.000 25.04105 ? 279 ARG   A CB  1 
ATOM   2154 C CG  . ARG   A 1 279 ? -30.12248 -39.42604 8.91619   1.000 27.57681 ? 279 ARG   A CG  1 
ATOM   2155 C CD  . ARG   A 1 279 ? -29.62182 -39.66363 10.35890  1.000 29.07302 ? 279 ARG   A CD  1 
ATOM   2156 N NE  . ARG   A 1 279 ? -28.35246 -40.39784 10.40966  1.000 27.86398 ? 279 ARG   A NE  1 
ATOM   2157 C CZ  . ARG   A 1 279 ? -28.05702 -41.34971 11.29805  1.000 25.59569 ? 279 ARG   A CZ  1 
ATOM   2158 N NH1 . ARG   A 1 279 ? -28.94557 -41.70039 12.22747  1.000 17.23990 ? 279 ARG   A NH1 1 
ATOM   2159 N NH2 . ARG   A 1 279 ? -26.87002 -41.95952 11.25509  1.000 18.23606 ? 279 ARG   A NH2 1 
ATOM   2160 N N   . THR   A 1 280 ? -29.53960 -35.55503 6.89545   1.000 17.88911 ? 280 THR   A N   1 
ATOM   2161 C CA  . THR   A 1 280 ? -28.90460 -34.29143 6.53436   1.000 21.22406 ? 280 THR   A CA  1 
ATOM   2162 C C   . THR   A 1 280 ? -28.52177 -33.51425 7.78359   1.000 19.49688 ? 280 THR   A C   1 
ATOM   2163 O O   . THR   A 1 280 ? -28.92391 -33.83774 8.89777   1.000 18.47404 ? 280 THR   A O   1 
ATOM   2164 C CB  . THR   A 1 280 ? -29.77804 -33.39986 5.64079   1.000 17.70274 ? 280 THR   A CB  1 
ATOM   2165 O OG1 . THR   A 1 280 ? -30.88653 -32.89323 6.39069   1.000 19.23616 ? 280 THR   A OG1 1 
ATOM   2166 C CG2 . THR   A 1 280 ? -30.26036 -34.16143 4.39435   1.000 19.24797 ? 280 THR   A CG2 1 
ATOM   2167 N N   . ILE   A 1 281 ? -27.72986 -32.46462 7.57294   1.000 22.45732 ? 281 ILE   A N   1 
ATOM   2168 C CA  . ILE   A 1 281 ? -27.28793 -31.56588 8.63343   1.000 18.61749 ? 281 ILE   A CA  1 
ATOM   2169 C C   . ILE   A 1 281 ? -27.43436 -30.13896 8.11528   1.000 17.73980 ? 281 ILE   A C   1 
ATOM   2170 O O   . ILE   A 1 281 ? -26.82776 -29.77525 7.09470   1.000 16.48439 ? 281 ILE   A O   1 
ATOM   2171 C CB  . ILE   A 1 281 ? -25.83783 -31.83542 9.08430   1.000 12.42165 ? 281 ILE   A CB  1 
ATOM   2172 C CG1 . ILE   A 1 281 ? -25.62509 -33.30052 9.45389   1.000 19.32736 ? 281 ILE   A CG1 1 
ATOM   2173 C CG2 . ILE   A 1 281 ? -25.47290 -30.97959 10.26546  1.000 15.61877 ? 281 ILE   A CG2 1 
ATOM   2174 C CD1 . ILE   A 1 281 ? -24.17473 -33.65523 9.69415   1.000 17.42523 ? 281 ILE   A CD1 1 
ATOM   2175 N N   . LEU   A 1 282 ? -28.23987 -29.34034 8.81406   1.000 17.18581 ? 282 LEU   A N   1 
ATOM   2176 C CA  . LEU   A 1 282 ? -28.55008 -27.96008 8.43330   1.000 13.67265 ? 282 LEU   A CA  1 
ATOM   2177 C C   . LEU   A 1 282 ? -28.94674 -27.87730 6.95795   1.000 15.25449 ? 282 LEU   A C   1 
ATOM   2178 O O   . LEU   A 1 282 ? -28.35706 -27.14194 6.16514   1.000 13.47030 ? 282 LEU   A O   1 
ATOM   2179 C CB  . LEU   A 1 282 ? -27.37278 -27.03040 8.75510   1.000 11.97766 ? 282 LEU   A CB  1 
ATOM   2180 C CG  . LEU   A 1 282 ? -27.00487 -26.81337 10.22978  1.000 12.22097 ? 282 LEU   A CG  1 
ATOM   2181 C CD1 . LEU   A 1 282 ? -25.74434 -25.97645 10.31840  1.000 15.27349 ? 282 LEU   A CD1 1 
ATOM   2182 C CD2 . LEU   A 1 282 ? -28.13792 -26.14503 11.02699  1.000 15.23197 ? 282 LEU   A CD2 1 
ATOM   2183 N N   . GLY   A 1 283 ? -29.97507 -28.65783 6.60761   1.000 12.24936 ? 283 GLY   A N   1 
ATOM   2184 C CA  . GLY   A 1 283 ? -30.46318 -28.77782 5.24659   1.000 12.80607 ? 283 GLY   A CA  1 
ATOM   2185 C C   . GLY   A 1 283 ? -29.40456 -29.11749 4.21215   1.000 19.86951 ? 283 GLY   A C   1 
ATOM   2186 O O   . GLY   A 1 283 ? -29.56859 -28.80378 3.02979   1.000 18.16259 ? 283 GLY   A O   1 
ATOM   2187 N N   . SER   A 1 284 ? -28.30407 -29.74852 4.62105   1.000 20.84773 ? 284 SER   A N   1 
ATOM   2188 C CA  . SER   A 1 284 ? -27.28206 -30.14861 3.65988   1.000 22.59212 ? 284 SER   A CA  1 
ATOM   2189 C C   . SER   A 1 284 ? -27.00681 -31.63887 3.78441   1.000 19.75387 ? 284 SER   A C   1 
ATOM   2190 O O   . SER   A 1 284 ? -26.99369 -32.19338 4.88513   1.000 19.88351 ? 284 SER   A O   1 
ATOM   2191 C CB  . SER   A 1 284 ? -25.97463 -29.33142 3.84737   1.000 19.42119 ? 284 SER   A CB  1 
ATOM   2192 O OG  . SER   A 1 284 ? -24.95971 -29.69018 2.90505   1.000 19.87833 ? 284 SER   A OG  1 
ATOM   2193 N N   . ALA   A 1 285 ? -26.78546 -32.28721 2.65283   1.000 19.31574 ? 285 ALA   A N   1 
ATOM   2194 C CA  . ALA   A 1 285 ? -26.31466 -33.65809 2.66876   1.000 17.46182 ? 285 ALA   A CA  1 
ATOM   2195 C C   . ALA   A 1 285 ? -24.79114 -33.75162 2.66357   1.000 18.68587 ? 285 ALA   A C   1 
ATOM   2196 O O   . ALA   A 1 285 ? -24.25690 -34.85691 2.50219   1.000 18.23619 ? 285 ALA   A O   1 
ATOM   2197 C CB  . ALA   A 1 285 ? -26.89837 -34.42494 1.48063   1.000 21.29391 ? 285 ALA   A CB  1 
ATOM   2198 N N   . LEU   A 1 286 ? -24.08410 -32.62677 2.86754   1.000 16.00911 ? 286 LEU   A N   1 
ATOM   2199 C CA  . LEU   A 1 286 ? -22.62886 -32.57963 2.77217   1.000 17.74252 ? 286 LEU   A CA  1 
ATOM   2200 C C   . LEU   A 1 286 ? -22.00885 -31.91406 4.00060   1.000 15.11668 ? 286 LEU   A C   1 
ATOM   2201 O O   . LEU   A 1 286 ? -22.60104 -31.04149 4.64193   1.000 13.20899 ? 286 LEU   A O   1 
ATOM   2202 C CB  . LEU   A 1 286 ? -22.16736 -31.84040 1.49115   1.000 20.40518 ? 286 LEU   A CB  1 
ATOM   2203 C CG  . LEU   A 1 286 ? -22.24732 -32.68639 0.21804   1.000 25.18000 ? 286 LEU   A CG  1 
ATOM   2204 C CD1 . LEU   A 1 286 ? -21.51450 -32.03404 -0.94737  1.000 20.81584 ? 286 LEU   A CD1 1 
ATOM   2205 C CD2 . LEU   A 1 286 ? -21.70675 -34.09191 0.47953   1.000 19.93441 ? 286 LEU   A CD2 1 
ATOM   2206 N N   . LEU   A 1 287 ? -20.80958 -32.35837 4.33964   1.000 10.39174 ? 287 LEU   A N   1 
ATOM   2207 C CA  . LEU   A 1 287 ? -20.04989 -31.70251 5.38915   1.000 17.30820 ? 287 LEU   A CA  1 
ATOM   2208 C C   . LEU   A 1 287 ? -19.56715 -30.35961 4.84833   1.000 14.05219 ? 287 LEU   A C   1 
ATOM   2209 O O   . LEU   A 1 287 ? -18.74798 -30.31469 3.92109   1.000 10.21778 ? 287 LEU   A O   1 
ATOM   2210 C CB  . LEU   A 1 287 ? -18.89987 -32.61244 5.83274   1.000 21.48753 ? 287 LEU   A CB  1 
ATOM   2211 C CG  . LEU   A 1 287 ? -19.33409 -34.02367 6.29657   1.000 19.50913 ? 287 LEU   A CG  1 
ATOM   2212 C CD1 . LEU   A 1 287 ? -18.19400 -34.87442 6.87564   1.000 11.76656 ? 287 LEU   A CD1 1 
ATOM   2213 C CD2 . LEU   A 1 287 ? -20.46870 -33.94765 7.32541   1.000 17.61559 ? 287 LEU   A CD2 1 
ATOM   2214 N N   . GLU   A 1 288 ? -20.08796 -29.26558 5.40977   1.000 9.47552  ? 288 GLU   A N   1 
ATOM   2215 C CA  . GLU   A 1 288 ? -19.88706 -27.92053 4.87235   1.000 12.03677 ? 288 GLU   A CA  1 
ATOM   2216 C C   . GLU   A 1 288 ? -18.66366 -27.25930 5.51649   1.000 13.41284 ? 288 GLU   A C   1 
ATOM   2217 O O   . GLU   A 1 288 ? -18.55516 -27.18665 6.74491   1.000 9.34810  ? 288 GLU   A O   1 
ATOM   2218 C CB  . GLU   A 1 288 ? -21.15863 -27.08891 5.07858   1.000 9.65060  ? 288 GLU   A CB  1 
ATOM   2219 C CG  . GLU   A 1 288 ? -21.10458 -25.61917 4.64238   1.000 13.28722 ? 288 GLU   A CG  1 
ATOM   2220 C CD  . GLU   A 1 288 ? -20.88509 -25.43025 3.13683   1.000 24.16465 ? 288 GLU   A CD  1 
ATOM   2221 O OE1 . GLU   A 1 288 ? -20.14358 -24.48674 2.76240   1.000 15.31401 ? 288 GLU   A OE1 1 
ATOM   2222 O OE2 . GLU   A 1 288 ? -21.41899 -26.24048 2.33401   1.000 22.44289 ? 288 GLU   A OE2 1 
ATOM   2223 N N   . ASP   A 1 289 ? -17.72989 -26.79042 4.68473   1.000 10.25176 ? 289 ASP   A N   1 
ATOM   2224 C CA  . ASP   A 1 289 ? -16.46872 -26.24924 5.17633   1.000 8.12508  ? 289 ASP   A CA  1 
ATOM   2225 C C   . ASP   A 1 289 ? -16.29414 -24.75745 4.87474   1.000 5.54424  ? 289 ASP   A C   1 
ATOM   2226 O O   . ASP   A 1 289 ? -15.17367 -24.24584 4.93036   1.000 6.34757  ? 289 ASP   A O   1 
ATOM   2227 C CB  . ASP   A 1 289 ? -15.30386 -27.06706 4.60554   1.000 7.67959  ? 289 ASP   A CB  1 
ATOM   2228 C CG  . ASP   A 1 289 ? -14.92405 -26.67403 3.16102   1.000 10.24117 ? 289 ASP   A CG  1 
ATOM   2229 O OD1 . ASP   A 1 289 ? -15.65672 -25.90603 2.50055   1.000 9.61212  ? 289 ASP   A OD1 1 
ATOM   2230 O OD2 . ASP   A 1 289 ? -13.88206 -27.16960 2.67544   1.000 10.39987 ? 289 ASP   A OD2 1 
ATOM   2231 N N   . GLU   A 1 290 ? -17.35725 -24.04589 4.52825   1.000 7.55613  ? 290 GLU   A N   1 
ATOM   2232 C CA  . GLU   A 1 290 ? -17.18620 -22.63714 4.20298   1.000 13.57276 ? 290 GLU   A CA  1 
ATOM   2233 C C   . GLU   A 1 290 ? -17.81105 -21.70822 5.23718   1.000 8.31754  ? 290 GLU   A C   1 
ATOM   2234 O O   . GLU   A 1 290 ? -18.17216 -20.58068 4.90142   1.000 7.02226  ? 290 GLU   A O   1 
ATOM   2235 C CB  . GLU   A 1 290 ? -17.67329 -22.32217 2.78193   1.000 12.14536 ? 290 GLU   A CB  1 
ATOM   2236 C CG  . GLU   A 1 290 ? -16.74871 -23.00399 1.72452   1.000 20.31168 ? 290 GLU   A CG  1 
ATOM   2237 C CD  . GLU   A 1 290 ? -16.72954 -22.36362 0.31661   1.000 25.34841 ? 290 GLU   A CD  1 
ATOM   2238 O OE1 . GLU   A 1 290 ? -17.48273 -21.38706 0.05576   1.000 12.04988 ? 290 GLU   A OE1 1 
ATOM   2239 O OE2 . GLU   A 1 290 ? -15.88613 -22.82087 -0.51523  1.000 18.46913 ? 290 GLU   A OE2 1 
ATOM   2240 N N   . PHE   A 1 291 ? -17.86551 -22.14172 6.51294   1.000 10.00423 ? 291 PHE   A N   1 
ATOM   2241 C CA  . PHE   A 1 291 ? -18.10939 -21.25444 7.65942   1.000 7.07734  ? 291 PHE   A CA  1 
ATOM   2242 C C   . PHE   A 1 291 ? -16.98718 -21.36323 8.70322   1.000 8.99428  ? 291 PHE   A C   1 
ATOM   2243 O O   . PHE   A 1 291 ? -16.67963 -22.46235 9.17438   1.000 9.08958  ? 291 PHE   A O   1 
ATOM   2244 C CB  . PHE   A 1 291 ? -19.43460 -21.56818 8.36429   1.000 13.24548 ? 291 PHE   A CB  1 
ATOM   2245 C CG  . PHE   A 1 291 ? -20.67390 -21.44511 7.49691   1.000 9.38339  ? 291 PHE   A CG  1 
ATOM   2246 C CD1 . PHE   A 1 291 ? -21.34440 -20.24369 7.39045   1.000 13.46280 ? 291 PHE   A CD1 1 
ATOM   2247 C CD2 . PHE   A 1 291 ? -21.19034 -22.54471 6.84190   1.000 7.43921  ? 291 PHE   A CD2 1 
ATOM   2248 C CE1 . PHE   A 1 291 ? -22.50956 -20.14756 6.60754   1.000 22.62812 ? 291 PHE   A CE1 1 
ATOM   2249 C CE2 . PHE   A 1 291 ? -22.34086 -22.45807 6.07102   1.000 9.08693  ? 291 PHE   A CE2 1 
ATOM   2250 C CZ  . PHE   A 1 291 ? -23.00930 -21.27798 5.98118   1.000 7.47613  ? 291 PHE   A CZ  1 
ATOM   2251 N N   . THR   A 1 292 ? -16.42648 -20.22460 9.12259   1.000 8.44792  ? 292 THR   A N   1 
ATOM   2252 C CA  . THR   A 1 292 ? -15.40312 -20.20248 10.16555  1.000 11.28594 ? 292 THR   A CA  1 
ATOM   2253 C C   . THR   A 1 292 ? -16.05615 -20.22573 11.54434  1.000 12.78648 ? 292 THR   A C   1 
ATOM   2254 O O   . THR   A 1 292 ? -17.28613 -20.13834 11.67618  1.000 10.86472 ? 292 THR   A O   1 
ATOM   2255 C CB  . THR   A 1 292 ? -14.52010 -18.96039 10.01203  1.000 9.57407  ? 292 THR   A CB  1 
ATOM   2256 O OG1 . THR   A 1 292 ? -15.29658 -17.78024 10.24227  1.000 11.51102 ? 292 THR   A OG1 1 
ATOM   2257 C CG2 . THR   A 1 292 ? -13.91968 -18.89902 8.61359   1.000 9.39115  ? 292 THR   A CG2 1 
ATOM   2258 N N   . PRO   A 1 293 ? -15.26309 -20.36951 12.61593  1.000 8.03312  ? 293 PRO   A N   1 
ATOM   2259 C CA  . PRO   A 1 293 ? -15.85654 -20.20736 13.94985  1.000 13.00326 ? 293 PRO   A CA  1 
ATOM   2260 C C   . PRO   A 1 293 ? -16.51752 -18.84593 14.11941  1.000 11.94736 ? 293 PRO   A C   1 
ATOM   2261 O O   . PRO   A 1 293 ? -17.62265 -18.76890 14.66144  1.000 11.90738 ? 293 PRO   A O   1 
ATOM   2262 C CB  . PRO   A 1 293 ? -14.65981 -20.41428 14.89133  1.000 15.93874 ? 293 PRO   A CB  1 
ATOM   2263 C CG  . PRO   A 1 293 ? -13.71610 -21.25983 14.12262  1.000 16.33436 ? 293 PRO   A CG  1 
ATOM   2264 C CD  . PRO   A 1 293 ? -13.85978 -20.82346 12.69217  1.000 14.28111 ? 293 PRO   A CD  1 
ATOM   2265 N N   . PHE   A 1 294 ? -15.89848 -17.77886 13.59552  1.000 15.12653 ? 294 PHE   A N   1 
ATOM   2266 C CA  . PHE   A 1 294 ? -16.44530 -16.42806 13.72840  1.000 18.19362 ? 294 PHE   A CA  1 
ATOM   2267 C C   . PHE   A 1 294 ? -17.80348 -16.29698 13.04584  1.000 18.72548 ? 294 PHE   A C   1 
ATOM   2268 O O   . PHE   A 1 294 ? -18.71749 -15.65819 13.58290  1.000 19.59416 ? 294 PHE   A O   1 
ATOM   2269 C CB  . PHE   A 1 294 ? -15.45775 -15.41629 13.14493  1.000 20.19938 ? 294 PHE   A CB  1 
ATOM   2270 C CG  . PHE   A 1 294 ? -15.99660 -14.00315 13.05998  1.000 29.97894 ? 294 PHE   A CG  1 
ATOM   2271 C CD1 . PHE   A 1 294 ? -16.86899 -13.61798 12.04007  1.000 25.09410 ? 294 PHE   A CD1 1 
ATOM   2272 C CD2 . PHE   A 1 294 ? -15.59791 -13.04994 13.97540  1.000 31.05335 ? 294 PHE   A CD2 1 
ATOM   2273 C CE1 . PHE   A 1 294 ? -17.34370 -12.32285 11.96212  1.000 27.74699 ? 294 PHE   A CE1 1 
ATOM   2274 C CE2 . PHE   A 1 294 ? -16.06804 -11.75549 13.89408  1.000 32.80866 ? 294 PHE   A CE2 1 
ATOM   2275 C CZ  . PHE   A 1 294 ? -16.94591 -11.39340 12.89075  1.000 33.69496 ? 294 PHE   A CZ  1 
ATOM   2276 N N   . ASP   A 1 295 ? -17.93601 -16.84433 11.83092  1.000 17.25249 ? 295 ASP   A N   1 
ATOM   2277 C CA  . ASP   A 1 295 ? -19.23240 -16.85748 11.14631  1.000 15.19220 ? 295 ASP   A CA  1 
ATOM   2278 C C   . ASP   A 1 295 ? -20.32104 -17.47474 12.01801  1.000 18.31966 ? 295 ASP   A C   1 
ATOM   2279 O O   . ASP   A 1 295 ? -21.42187 -16.92336 12.13413  1.000 17.74736 ? 295 ASP   A O   1 
ATOM   2280 C CB  . ASP   A 1 295 ? -19.13050 -17.62201 9.83353   1.000 9.16400  ? 295 ASP   A CB  1 
ATOM   2281 C CG  . ASP   A 1 295 ? -18.14675 -16.99827 8.88210   1.000 9.33394  ? 295 ASP   A CG  1 
ATOM   2282 O OD1 . ASP   A 1 295 ? -17.84283 -15.81269 9.10346   1.000 7.11218  ? 295 ASP   A OD1 1 
ATOM   2283 O OD2 . ASP   A 1 295 ? -17.69949 -17.68966 7.91818   1.000 7.86358  ? 295 ASP   A OD2 1 
ATOM   2284 N N   . VAL   A 1 296 ? -20.03680 -18.64088 12.61189  1.000 13.10419 ? 296 VAL   A N   1 
ATOM   2285 C CA  . VAL   A 1 296 ? -21.01351 -19.29771 13.47718  1.000 17.80180 ? 296 VAL   A CA  1 
ATOM   2286 C C   . VAL   A 1 296 ? -21.38244 -18.39132 14.64172  1.000 17.35098 ? 296 VAL   A C   1 
ATOM   2287 O O   . VAL   A 1 296 ? -22.56366 -18.15905 14.91868  1.000 20.34505 ? 296 VAL   A O   1 
ATOM   2288 C CB  . VAL   A 1 296 ? -20.47528 -20.64909 13.98093  1.000 11.73866 ? 296 VAL   A CB  1 
ATOM   2289 C CG1 . VAL   A 1 296 ? -21.48989 -21.31509 14.91385  1.000 13.16784 ? 296 VAL   A CG1 1 
ATOM   2290 C CG2 . VAL   A 1 296 ? -20.14283 -21.54367 12.82526  1.000 6.61118  ? 296 VAL   A CG2 1 
ATOM   2291 N N   . VAL   A 1 297 ? -20.37572 -17.88092 15.35394  1.000 17.59564 ? 297 VAL   A N   1 
ATOM   2292 C CA  . VAL   A 1 297 ? -20.65077 -17.00148 16.48820  1.000 16.66782 ? 297 VAL   A CA  1 
ATOM   2293 C C   . VAL   A 1 297 ? -21.39157 -15.74781 16.02421  1.000 28.67601 ? 297 VAL   A C   1 
ATOM   2294 O O   . VAL   A 1 297 ? -22.14184 -15.14194 16.80271  1.000 29.47181 ? 297 VAL   A O   1 
ATOM   2295 C CB  . VAL   A 1 297 ? -19.34230 -16.66561 17.24699  1.000 20.26619 ? 297 VAL   A CB  1 
ATOM   2296 C CG1 . VAL   A 1 297 ? -19.62851 -15.81604 18.45700  1.000 18.68078 ? 297 VAL   A CG1 1 
ATOM   2297 C CG2 . VAL   A 1 297 ? -18.59016 -17.95114 17.68383  1.000 20.07563 ? 297 VAL   A CG2 1 
ATOM   2298 N N   . ARG   A 1 298 ? -21.23672 -15.36507 14.74474  1.000 18.11180 ? 298 ARG   A N   1 
ATOM   2299 C CA  . ARG   A 1 298 ? -21.96319 -14.21204 14.20835  1.000 26.37478 ? 298 ARG   A CA  1 
ATOM   2300 C C   . ARG   A 1 298 ? -23.45743 -14.50217 14.07337  1.000 23.49328 ? 298 ARG   A C   1 
ATOM   2301 O O   . ARG   A 1 298 ? -24.28736 -13.78211 14.64074  1.000 26.04375 ? 298 ARG   A O   1 
ATOM   2302 C CB  . ARG   A 1 298 ? -21.36919 -13.77632 12.85654  1.000 23.43164 ? 298 ARG   A CB  1 
ATOM   2303 C CG  . ARG   A 1 298 ? -22.34012 -12.96065 11.96726  1.000 30.05117 ? 298 ARG   A CG  1 
ATOM   2304 C CD  . ARG   A 1 298 ? -21.62472 -12.03293 10.94739  1.000 24.73996 ? 298 ARG   A CD  1 
ATOM   2305 N NE  . ARG   A 1 298 ? -21.25479 -12.71243 9.69751   1.000 24.84869 ? 298 ARG   A NE  1 
ATOM   2306 C CZ  . ARG   A 1 298 ? -21.88497 -12.57631 8.53001   1.000 18.81691 ? 298 ARG   A CZ  1 
ATOM   2307 N NH1 . ARG   A 1 298 ? -22.93444 -11.76968 8.42101   1.000 19.81697 ? 298 ARG   A NH1 1 
ATOM   2308 N NH2 . ARG   A 1 298 ? -21.45644 -13.24229 7.46268   1.000 15.70776 ? 298 ARG   A NH2 1 
ATOM   2309 N N   . GLN   A 1 299 ? -23.82372 -15.54779 13.30946  1.000 22.02601 ? 299 GLN   A N   1 
ATOM   2310 C CA  . GLN   A 1 299 ? -25.24023 -15.86226 13.10293  1.000 22.18330 ? 299 GLN   A CA  1 
ATOM   2311 C C   . GLN   A 1 299 ? -25.86430 -16.49034 14.33942  1.000 28.70413 ? 299 GLN   A C   1 
ATOM   2312 O O   . GLN   A 1 299 ? -26.99445 -16.15205 14.70348  1.000 33.02366 ? 299 GLN   A O   1 
ATOM   2313 C CB  . GLN   A 1 299 ? -25.45170 -16.80854 11.91030  1.000 19.03768 ? 299 GLN   A CB  1 
ATOM   2314 C CG  . GLN   A 1 299 ? -25.01012 -16.28903 10.55229  1.000 20.83876 ? 299 GLN   A CG  1 
ATOM   2315 C CD  . GLN   A 1 299 ? -25.49191 -17.16027 9.39889   1.000 14.76151 ? 299 GLN   A CD  1 
ATOM   2316 O OE1 . GLN   A 1 299 ? -26.67439 -17.49730 9.30060   1.000 21.13526 ? 299 GLN   A OE1 1 
ATOM   2317 N NE2 . GLN   A 1 299 ? -24.55889 -17.58102 8.55578   1.000 14.36423 ? 299 GLN   A NE2 1 
ATOM   2318 N N   . CYS   A 1 300 ? -25.17089 -17.42899 14.97900  1.000 24.69387 ? 300 CYS   A N   1 
ATOM   2319 C CA  . CYS   A 1 300 ? -25.76013 -18.12526 16.11959  1.000 29.44253 ? 300 CYS   A CA  1 
ATOM   2320 C C   . CYS   A 1 300 ? -25.68405 -17.31547 17.42133  1.000 29.54230 ? 300 CYS   A C   1 
ATOM   2321 O O   . CYS   A 1 300 ? -25.96322 -17.86929 18.49266  1.000 40.91422 ? 300 CYS   A O   1 
ATOM   2322 C CB  . CYS   A 1 300 ? -25.10520 -19.50385 16.28770  1.000 18.74460 ? 300 CYS   A CB  1 
ATOM   2323 S SG  . CYS   A 1 300 ? -25.24078 -20.60116 14.80416  1.000 23.69500 ? 300 CYS   A SG  1 
ATOM   2324 N N   . SER   A 1 301 ? -25.33732 -16.02194 17.35933  1.000 33.07266 ? 301 SER   A N   1 
ATOM   2325 C CA  . SER   A 1 301 ? -25.42456 -15.15684 18.53662  1.000 37.82874 ? 301 SER   A CA  1 
ATOM   2326 C C   . SER   A 1 301 ? -25.89311 -13.74097 18.19365  1.000 45.06249 ? 301 SER   A C   1 
ATOM   2327 O O   . SER   A 1 301 ? -26.96296 -13.32043 18.65573  1.000 47.53138 ? 301 SER   A O   1 
ATOM   2328 C CB  . SER   A 1 301 ? -24.08469 -15.09649 19.27817  1.000 42.22261 ? 301 SER   A CB  1 
ATOM   2329 O OG  . SER   A 1 301 ? -24.23965 -14.47667 20.54840  1.000 36.87733 ? 301 SER   A OG  1 
ATOM   2330 N N   . GLY   A 1 302 ? -25.10391 -12.98149 17.42149  1.000 38.73279 ? 302 GLY   A N   1 
ATOM   2331 C CA  . GLY   A 1 302 ? -25.54556 -11.65757 17.00643  1.000 39.61476 ? 302 GLY   A CA  1 
ATOM   2332 C C   . GLY   A 1 302 ? -24.51139 -10.54421 16.99058  1.000 45.67865 ? 302 GLY   A C   1 
ATOM   2333 O O   . GLY   A 1 302 ? -24.02282 -10.12658 18.04725  1.000 47.19542 ? 302 GLY   A O   1 
ATOM   2334 N N   . VAL   A 1 303 ? -24.18216 -10.05505 15.78892  1.000 52.36063 ? 303 VAL   A N   1 
ATOM   2335 C CA  . VAL   A 1 303 ? -23.30761 -8.89822  15.57765  1.000 48.31758 ? 303 VAL   A CA  1 
ATOM   2336 C C   . VAL   A 1 303 ? -23.77415 -8.17397  14.31806  1.000 51.34720 ? 303 VAL   A C   1 
ATOM   2337 O O   . VAL   A 1 303 ? -24.01167 -8.81169  13.28448  1.000 45.30175 ? 303 VAL   A O   1 
ATOM   2338 C CB  . VAL   A 1 303 ? -21.82070 -9.29483  15.44022  1.000 42.02977 ? 303 VAL   A CB  1 
ATOM   2339 C CG1 . VAL   A 1 303 ? -21.02876 -8.17827  14.77387  1.000 36.12521 ? 303 VAL   A CG1 1 
ATOM   2340 C CG2 . VAL   A 1 303 ? -21.21390 -9.63301  16.80333  1.000 41.93266 ? 303 VAL   A CG2 1 
ATOM   2341 N N   . THR   A 1 304 ? -23.89825 -6.84524  14.39978  1.000 53.14207 ? 304 THR   A N   1 
ATOM   2342 C CA  . THR   A 1 304 ? -24.33174 -6.00266  13.28658  1.000 45.94582 ? 304 THR   A CA  1 
ATOM   2343 C C   . THR   A 1 304 ? -23.25270 -4.97049  12.96114  1.000 45.19198 ? 304 THR   A C   1 
ATOM   2344 O O   . THR   A 1 304 ? -22.22317 -4.87363  13.64161  1.000 43.18552 ? 304 THR   A O   1 
ATOM   2345 C CB  . THR   A 1 304 ? -25.67738 -5.30920  13.59259  1.000 44.12151 ? 304 THR   A CB  1 
ATOM   2346 O OG1 . THR   A 1 304 ? -25.49785 -4.29133  14.58731  1.000 58.78003 ? 304 THR   A OG1 1 
ATOM   2347 C CG2 . THR   A 1 304 ? -26.70063 -6.31313  14.10365  1.000 31.05812 ? 304 THR   A CG2 1 
ATOM   2348 N N   . PHE   A 1 305 ? -23.49818 -4.19192  11.90245  1.000 42.63106 ? 305 PHE   A N   1 
ATOM   2349 C CA  . PHE   A 1 305 ? -22.47472 -3.32201  11.32611  1.000 49.63900 ? 305 PHE   A CA  1 
ATOM   2350 C C   . PHE   A 1 305 ? -23.08215 -1.97234  10.94506  1.000 46.08912 ? 305 PHE   A C   1 
ATOM   2351 O O   . PHE   A 1 305 ? -24.30210 -1.82730  10.82520  1.000 43.83656 ? 305 PHE   A O   1 
ATOM   2352 C CB  . PHE   A 1 305 ? -21.79389 -4.01418  10.12214  1.000 37.67677 ? 305 PHE   A CB  1 
ATOM   2353 C CG  . PHE   A 1 305 ? -21.42555 -5.45950  10.39731  1.000 41.50481 ? 305 PHE   A CG  1 
ATOM   2354 C CD1 . PHE   A 1 305 ? -20.23205 -5.77675  11.04449  1.000 37.31952 ? 305 PHE   A CD1 1 
ATOM   2355 C CD2 . PHE   A 1 305 ? -22.30080 -6.49435  10.06326  1.000 37.07489 ? 305 PHE   A CD2 1 
ATOM   2356 C CE1 . PHE   A 1 305 ? -19.90331 -7.09268  11.32691  1.000 34.47316 ? 305 PHE   A CE1 1 
ATOM   2357 C CE2 . PHE   A 1 305 ? -21.98131 -7.81328  10.34250  1.000 28.48158 ? 305 PHE   A CE2 1 
ATOM   2358 C CZ  . PHE   A 1 305 ? -20.78094 -8.10761  10.99092  1.000 38.59858 ? 305 PHE   A CZ  1 
ATOM   2359 N N   . GLN   A 1 306 ? -22.20751 -0.97816  10.76338  1.000 46.64692 ? 306 GLN   A N   1 
ATOM   2360 C CA  . GLN   A 1 306 ? -22.62321 0.41395   10.56084  1.000 47.74668 ? 306 GLN   A CA  1 
ATOM   2361 C C   . GLN   A 1 306 ? -21.54173 1.21376   9.83810   1.000 45.85844 ? 306 GLN   A C   1 
ATOM   2362 O O   . GLN   A 1 306 ? -21.15177 2.30234   10.27789  1.000 39.12100 ? 306 GLN   A O   1 
ATOM   2363 C CB  . GLN   A 1 306 ? -22.94958 1.07560   11.91021  1.000 57.37001 ? 306 GLN   A CB  1 
ATOM   2364 C CG  . GLN   A 1 306 ? -23.89589 2.29263   11.85733  1.000 52.18752 ? 306 GLN   A CG  1 
ATOM   2365 C CD  . GLN   A 1 306 ? -24.37831 2.73676   13.25075  1.000 57.23280 ? 306 GLN   A CD  1 
ATOM   2366 O OE1 . GLN   A 1 306 ? -23.74444 2.44174   14.26806  1.000 58.19458 ? 306 GLN   A OE1 1 
ATOM   2367 N NE2 . GLN   A 1 306 ? -25.51560 3.43229   13.29290  1.000 45.74360 ? 306 GLN   A NE2 1 
HETATM 2368 N N1  . A1AS4 B 2 .   ? -14.45462 -12.87092 -15.83406 1.000 35.92180 ? 401 A1AS4 A N1  1 
HETATM 2369 C C4  . A1AS4 B 2 .   ? -12.81546 -13.19164 -17.58316 1.000 41.86185 ? 401 A1AS4 A C4  1 
HETATM 2370 C C5  . A1AS4 B 2 .   ? -13.54137 -12.33862 -16.67524 1.000 38.72736 ? 401 A1AS4 A C5  1 
HETATM 2371 C C6  . A1AS4 B 2 .   ? -13.35424 -10.87236 -16.59888 1.000 33.42713 ? 401 A1AS4 A C6  1 
HETATM 2372 B B1  . A1AS4 B 2 .   ? -11.74050 -12.59306 -18.56771 1.000 32.17852 ? 401 A1AS4 A B1  1 
HETATM 2373 C C1  . A1AS4 B 2 .   ? -14.67181 -14.19892 -15.83571 1.000 28.97515 ? 401 A1AS4 A C1  1 
HETATM 2374 C C2  . A1AS4 B 2 .   ? -14.01801 -15.08124 -16.67425 1.000 33.74362 ? 401 A1AS4 A C2  1 
HETATM 2375 C C3  . A1AS4 B 2 .   ? -13.07800 -14.56828 -17.56044 1.000 34.25078 ? 401 A1AS4 A C3  1 
HETATM 2376 N N2  . A1AS4 B 2 .   ? -13.67099 -10.11276 -17.62915 1.000 42.88465 ? 401 A1AS4 A N2  1 
HETATM 2377 O O1  . A1AS4 B 2 .   ? -10.52322 -12.27407 -18.04469 1.000 25.75439 ? 401 A1AS4 A O1  1 
HETATM 2378 O O2  . A1AS4 B 2 .   ? -12.14742 -11.89879 -19.66195 1.000 40.40386 ? 401 A1AS4 A O2  1 
HETATM 2379 O O   . HOH   C 3 .   ? -3.61337  -23.78618 -6.73397  1.000 12.03889 ? 501 HOH   A O   1 
HETATM 2380 O O   . HOH   C 3 .   ? -1.55405  6.32577   -6.48977  1.000 19.50402 ? 502 HOH   A O   1 
HETATM 2381 O O   . HOH   C 3 .   ? -16.62226 5.05065   -5.89651  1.000 40.74705 ? 503 HOH   A O   1 
HETATM 2382 O O   . HOH   C 3 .   ? -6.07013  6.91025   -20.46209 1.000 37.12901 ? 504 HOH   A O   1 
HETATM 2383 O O   . HOH   C 3 .   ? -27.17589 -37.97303 4.22288   1.000 43.54325 ? 505 HOH   A O   1 
HETATM 2384 O O   . HOH   C 3 .   ? -9.37705  -24.81901 -13.75151 1.000 24.11966 ? 506 HOH   A O   1 
HETATM 2385 O O   . HOH   C 3 .   ? -26.63441 -0.09365  -12.98002 1.000 39.56066 ? 507 HOH   A O   1 
HETATM 2386 O O   . HOH   C 3 .   ? -27.28793 -14.04899 20.61350  1.000 31.59814 ? 508 HOH   A O   1 
HETATM 2387 O O   . HOH   C 3 .   ? -16.83331 -10.61337 4.03299   1.000 33.65459 ? 509 HOH   A O   1 
HETATM 2388 O O   . HOH   C 3 .   ? -11.24862 -6.47216  13.90393  1.000 24.76685 ? 510 HOH   A O   1 
HETATM 2389 O O   . HOH   C 3 .   ? -22.67557 -27.97318 1.97289   1.000 17.02801 ? 511 HOH   A O   1 
HETATM 2390 O O   . HOH   C 3 .   ? -5.04432  -27.84025 -11.06658 1.000 33.07688 ? 512 HOH   A O   1 
HETATM 2391 O O   . HOH   C 3 .   ? 0.71735   -8.41509  -1.54253  1.000 20.96433 ? 513 HOH   A O   1 
HETATM 2392 O O   . HOH   C 3 .   ? 5.91296   -15.44435 -14.72095 1.000 25.12314 ? 514 HOH   A O   1 
HETATM 2393 O O   . HOH   C 3 .   ? -18.92156 -14.63755 -2.19477  1.000 38.74067 ? 515 HOH   A O   1 
HETATM 2394 O O   . HOH   C 3 .   ? -14.66571 -43.14374 16.49958  1.000 28.10002 ? 516 HOH   A O   1 
HETATM 2395 O O   . HOH   C 3 .   ? -16.15689 -23.95324 -11.22719 1.000 29.86788 ? 517 HOH   A O   1 
HETATM 2396 O O   . HOH   C 3 .   ? -16.26006 -24.89889 19.14793  1.000 32.42697 ? 518 HOH   A O   1 
HETATM 2397 O O   . HOH   C 3 .   ? -3.17747  -23.90199 23.43584  1.000 24.16734 ? 519 HOH   A O   1 
HETATM 2398 O O   . HOH   C 3 .   ? -4.41201  -19.47532 -18.55091 1.000 23.21000 ? 520 HOH   A O   1 
HETATM 2399 O O   . HOH   C 3 .   ? -29.23646 -29.38667 19.34891  1.000 25.82261 ? 521 HOH   A O   1 
HETATM 2400 O O   . HOH   C 3 .   ? 4.02622   -12.31310 -20.81313 1.000 24.91977 ? 522 HOH   A O   1 
HETATM 2401 O O   . HOH   C 3 .   ? -4.68461  -33.28405 7.42481   1.000 20.49756 ? 523 HOH   A O   1 
HETATM 2402 O O   . HOH   C 3 .   ? -25.64976 -10.57228 14.12171  1.000 31.70936 ? 524 HOH   A O   1 
HETATM 2403 O O   . HOH   C 3 .   ? -12.35043 -2.08360  -19.45092 1.000 26.32914 ? 525 HOH   A O   1 
HETATM 2404 O O   . HOH   C 3 .   ? 2.79022   -10.37254 -5.73252  1.000 23.64717 ? 526 HOH   A O   1 
HETATM 2405 O O   . HOH   C 3 .   ? -3.49125  -12.39342 -2.99813  1.000 23.55905 ? 527 HOH   A O   1 
HETATM 2406 O O   . HOH   C 3 .   ? 0.06781   5.48825   -7.15452  1.000 30.98314 ? 528 HOH   A O   1 
HETATM 2407 O O   . HOH   C 3 .   ? -4.49138  -14.00518 5.72023   1.000 33.68839 ? 529 HOH   A O   1 
HETATM 2408 O O   . HOH   C 3 .   ? -7.33275  -23.62738 5.56643   1.000 11.32494 ? 530 HOH   A O   1 
HETATM 2409 O O   . HOH   C 3 .   ? -3.42629  -21.21037 21.06353  1.000 19.31642 ? 531 HOH   A O   1 
HETATM 2410 O O   . HOH   C 3 .   ? -12.50037 -18.39435 19.42500  1.000 22.06456 ? 532 HOH   A O   1 
HETATM 2411 O O   . HOH   C 3 .   ? -10.64102 -26.57635 -9.30043  1.000 13.39706 ? 533 HOH   A O   1 
HETATM 2412 O O   . HOH   C 3 .   ? -16.26305 -26.87926 0.17980   1.000 28.32200 ? 534 HOH   A O   1 
HETATM 2413 O O   . HOH   C 3 .   ? -1.01673  -19.17325 4.15484   1.000 8.27854  ? 535 HOH   A O   1 
HETATM 2414 O O   . HOH   C 3 .   ? -4.81560  -21.05818 13.67405  1.000 17.64973 ? 536 HOH   A O   1 
HETATM 2415 O O   . HOH   C 3 .   ? -18.30782 -24.72185 7.54644   1.000 8.09973  ? 537 HOH   A O   1 
HETATM 2416 O O   . HOH   C 3 .   ? 0.11342   1.78487   -3.46755  1.000 33.04287 ? 538 HOH   A O   1 
HETATM 2417 O O   . HOH   C 3 .   ? -13.46484 -12.27672 -22.12432 1.000 29.32575 ? 539 HOH   A O   1 
HETATM 2418 O O   . HOH   C 3 .   ? -16.56240 -21.93898 -9.34268  1.000 18.44741 ? 540 HOH   A O   1 
HETATM 2419 O O   . HOH   C 3 .   ? -29.63120 -19.31398 14.37254  1.000 18.27772 ? 541 HOH   A O   1 
HETATM 2420 O O   . HOH   C 3 .   ? -15.43104 -20.89439 19.19875  1.000 19.20499 ? 542 HOH   A O   1 
HETATM 2421 O O   . HOH   C 3 .   ? -2.62916  -4.34321  2.14965   1.000 6.96826  ? 543 HOH   A O   1 
HETATM 2422 O O   . HOH   C 3 .   ? -20.88745 -39.09982 14.38359  1.000 16.52251 ? 544 HOH   A O   1 
HETATM 2423 O O   . HOH   C 3 .   ? -11.85265 -31.29567 23.75090  1.000 22.16361 ? 545 HOH   A O   1 
HETATM 2424 O O   . HOH   C 3 .   ? -20.28414 3.50970   -0.40997  1.000 13.40937 ? 546 HOH   A O   1 
HETATM 2425 O O   . HOH   C 3 .   ? -26.07101 -46.79357 7.51147   1.000 23.72385 ? 547 HOH   A O   1 
HETATM 2426 O O   . HOH   C 3 .   ? -1.47833  6.18364   -9.81900  1.000 27.17718 ? 548 HOH   A O   1 
HETATM 2427 O O   . HOH   C 3 .   ? -14.67316 -15.43813 9.10966   1.000 11.99781 ? 549 HOH   A O   1 
HETATM 2428 O O   . HOH   C 3 .   ? 2.05640   -7.88053  -27.34383 1.000 29.34753 ? 550 HOH   A O   1 
HETATM 2429 O O   . HOH   C 3 .   ? -17.39988 -31.44154 1.89847   1.000 25.71752 ? 551 HOH   A O   1 
HETATM 2430 O O   . HOH   C 3 .   ? -21.03059 2.94465   -11.97191 1.000 16.39187 ? 552 HOH   A O   1 
HETATM 2431 O O   . HOH   C 3 .   ? 0.92463   -12.04477 -12.99692 1.000 13.28728 ? 553 HOH   A O   1 
HETATM 2432 O O   . HOH   C 3 .   ? -18.58269 -26.14124 1.29499   1.000 28.76777 ? 554 HOH   A O   1 
HETATM 2433 O O   . HOH   C 3 .   ? -6.70059  -16.59619 -6.92356  1.000 11.69690 ? 555 HOH   A O   1 
HETATM 2434 O O   . HOH   C 3 .   ? -0.00000  -16.05772 0.00000   0.50  4.20133  ? 556 HOH   A O   1 
HETATM 2435 O O   . HOH   C 3 .   ? -12.78974 -15.12644 7.36958   1.000 24.14588 ? 557 HOH   A O   1 
HETATM 2436 O O   . HOH   C 3 .   ? -10.97569 -21.09003 9.68474   1.000 16.82505 ? 558 HOH   A O   1 
HETATM 2437 O O   . HOH   C 3 .   ? -17.08684 -13.64031 6.52540   1.000 8.67045  ? 559 HOH   A O   1 
HETATM 2438 O O   . HOH   C 3 .   ? -10.21419 -7.65844  7.87050   1.000 35.78692 ? 560 HOH   A O   1 
HETATM 2439 O O   . HOH   C 3 .   ? -8.61418  -6.88668  -21.57245 1.000 30.17945 ? 561 HOH   A O   1 
HETATM 2440 O O   . HOH   C 3 .   ? -15.82544 -25.21704 -1.87743  1.000 29.09582 ? 562 HOH   A O   1 
HETATM 2441 O O   . HOH   C 3 .   ? -19.32403 -17.65172 5.68551   1.000 11.77802 ? 563 HOH   A O   1 
HETATM 2442 O O   . HOH   C 3 .   ? -16.66790 -39.72656 3.48491   1.000 25.98907 ? 564 HOH   A O   1 
HETATM 2443 O O   . HOH   C 3 .   ? -6.41627  -35.60205 -2.98880  1.000 27.96811 ? 565 HOH   A O   1 
HETATM 2444 O O   . HOH   C 3 .   ? -2.89591  -10.13295 -20.65467 1.000 41.52524 ? 566 HOH   A O   1 
HETATM 2445 O O   . HOH   C 3 .   ? -3.58162  -23.30382 13.25714  1.000 13.82776 ? 567 HOH   A O   1 
HETATM 2446 O O   . HOH   C 3 .   ? -23.91005 -16.55716 -0.33110  1.000 15.18839 ? 568 HOH   A O   1 
HETATM 2447 O O   . HOH   C 3 .   ? -29.031   -1.820    -3.691    1.000 8.48065  ? 569 HOH   A O   1 
HETATM 2448 O O   . HOH   C 3 .   ? -7.36555  -15.52833 10.96743  1.000 16.26008 ? 570 HOH   A O   1 
HETATM 2449 O O   . HOH   C 3 .   ? -0.00000  -7.72612  0.00000   0.50  9.08490  ? 571 HOH   A O   1 
HETATM 2450 O O   . HOH   C 3 .   ? -11.67402 -26.84435 -5.02292  1.000 15.18455 ? 572 HOH   A O   1 
HETATM 2451 O O   . HOH   C 3 .   ? -5.29344  -24.27164 4.08909   1.000 23.63071 ? 573 HOH   A O   1 
HETATM 2452 O O   . HOH   C 3 .   ? -22.73962 -5.37380  -21.12967 1.000 21.52838 ? 574 HOH   A O   1 
HETATM 2453 O O   . HOH   C 3 .   ? -6.00358  -6.10794  0.24033   1.000 9.57775  ? 575 HOH   A O   1 
HETATM 2454 O O   . HOH   C 3 .   ? -13.87101 1.11410   -28.44865 1.000 26.01077 ? 576 HOH   A O   1 
HETATM 2455 O O   . HOH   C 3 .   ? -2.35855  -14.58456 2.59689   1.000 5.53246  ? 577 HOH   A O   1 
HETATM 2456 O O   . HOH   C 3 .   ? -13.18266 -28.98741 24.85191  1.000 26.88985 ? 578 HOH   A O   1 
HETATM 2457 O O   . HOH   C 3 .   ? -3.26233  -0.62411  -4.00420  1.000 19.76717 ? 579 HOH   A O   1 
HETATM 2458 O O   . HOH   C 3 .   ? -3.19112  -29.95361 -1.68680  1.000 20.16728 ? 580 HOH   A O   1 
HETATM 2459 O O   . HOH   C 3 .   ? -15.11358 -21.07356 -2.70926  1.000 4.84489  ? 581 HOH   A O   1 
HETATM 2460 O O   . HOH   C 3 .   ? -12.91270 -4.32997  9.01906   1.000 20.28791 ? 582 HOH   A O   1 
HETATM 2461 O O   . HOH   C 3 .   ? -7.97850  -19.39529 7.85404   1.000 29.38013 ? 583 HOH   A O   1 
HETATM 2462 O O   . HOH   C 3 .   ? -5.64226  -22.21320 -18.25553 1.000 32.19837 ? 584 HOH   A O   1 
HETATM 2463 O O   . HOH   C 3 .   ? -4.45383  -20.30528 6.45721   1.000 16.83095 ? 585 HOH   A O   1 
HETATM 2464 O O   . HOH   C 3 .   ? 9.279     -5.579    -15.592   1.000 29.73979 ? 586 HOH   A O   1 
HETATM 2465 O O   . HOH   C 3 .   ? -11.39204 -4.02227  10.47632  1.000 19.72506 ? 587 HOH   A O   1 
HETATM 2466 O O   . HOH   C 3 .   ? -16.83240 -38.26980 25.90811  1.000 22.03841 ? 588 HOH   A O   1 
HETATM 2467 O O   . HOH   C 3 .   ? -8.43959  -26.68732 9.54688   1.000 14.58195 ? 589 HOH   A O   1 
HETATM 2468 O O   . HOH   C 3 .   ? 1.41884   -12.90431 -4.56010  1.000 9.34915  ? 590 HOH   A O   1 
HETATM 2469 O O   . HOH   C 3 .   ? 4.91966   -16.63209 -21.82682 1.000 21.62728 ? 591 HOH   A O   1 
HETATM 2470 O O   . HOH   C 3 .   ? -7.36904  17.91812  -15.35985 1.000 25.77598 ? 592 HOH   A O   1 
HETATM 2471 O O   . HOH   C 3 .   ? -23.77738 -22.25153 -0.37993  1.000 32.58051 ? 593 HOH   A O   1 
HETATM 2472 O O   . HOH   C 3 .   ? 1.19059   -11.55257 -8.14635  1.000 5.78775  ? 594 HOH   A O   1 
HETATM 2473 O O   . HOH   C 3 .   ? -3.91713  -27.02295 8.97577   1.000 21.04018 ? 595 HOH   A O   1 
HETATM 2474 O O   . HOH   C 3 .   ? -22.20570 -15.95347 9.40175   1.000 13.80282 ? 596 HOH   A O   1 
HETATM 2475 O O   . HOH   C 3 .   ? -17.56087 -5.06520  -6.52331  1.000 10.83124 ? 597 HOH   A O   1 
HETATM 2476 O O   . HOH   C 3 .   ? 0.08590   -0.95171  -25.47808 1.000 27.47449 ? 598 HOH   A O   1 
HETATM 2477 O O   . HOH   C 3 .   ? 8.04150   -9.70903  -21.14311 1.000 23.22496 ? 599 HOH   A O   1 
HETATM 2478 O O   . HOH   C 3 .   ? 5.10232   -1.58941  -10.65049 1.000 30.84357 ? 600 HOH   A O   1 
HETATM 2479 O O   . HOH   C 3 .   ? -12.87821 -17.78351 13.48369  1.000 15.43946 ? 601 HOH   A O   1 
HETATM 2480 O O   . HOH   C 3 .   ? 1.16450   -12.97201 -10.90927 1.000 7.61365  ? 602 HOH   A O   1 
HETATM 2481 O O   . HOH   C 3 .   ? -5.03749  -0.75162  5.10604   1.000 12.53022 ? 603 HOH   A O   1 
HETATM 2482 O O   . HOH   C 3 .   ? 7.48910   -3.99348  -28.58928 1.000 18.37550 ? 604 HOH   A O   1 
HETATM 2483 O O   . HOH   C 3 .   ? -20.29091 -3.15903  -10.68329 1.000 32.25199 ? 605 HOH   A O   1 
HETATM 2484 O O   . HOH   C 3 .   ? -25.98080 -31.01193 0.00000   0.50  19.83093 ? 606 HOH   A O   1 
HETATM 2485 O O   . HOH   C 3 .   ? -1.17988  -37.51098 13.61535  1.000 27.04560 ? 607 HOH   A O   1 
HETATM 2486 O O   . HOH   C 3 .   ? -12.93051 -36.99397 1.35442   1.000 19.32862 ? 608 HOH   A O   1 
HETATM 2487 O O   . HOH   C 3 .   ? -10.47453 -25.44299 -6.95448  1.000 18.77866 ? 609 HOH   A O   1 
HETATM 2488 O O   . HOH   C 3 .   ? -19.59993 -22.11131 -7.47945  1.000 17.06742 ? 610 HOH   A O   1 
HETATM 2489 O O   . HOH   C 3 .   ? -21.98309 -16.68909 6.53556   1.000 6.69168  ? 611 HOH   A O   1 
HETATM 2490 O O   . HOH   C 3 .   ? -4.04040  12.26495  -22.11298 1.000 24.99651 ? 612 HOH   A O   1 
HETATM 2491 O O   . HOH   C 3 .   ? -32.10583 -36.65811 3.14488   1.000 16.35368 ? 613 HOH   A O   1 
HETATM 2492 O O   . HOH   C 3 .   ? 0.46144   -20.08660 -13.74072 1.000 24.97705 ? 614 HOH   A O   1 
HETATM 2493 O O   . HOH   C 3 .   ? 1.16965   -21.22217 -15.71645 1.000 14.89159 ? 615 HOH   A O   1 
HETATM 2494 O O   . HOH   C 3 .   ? -20.80439 6.98318   -7.07197  1.000 25.39473 ? 616 HOH   A O   1 
HETATM 2495 O O   . HOH   C 3 .   ? -22.05972 3.97629   -9.94421  1.000 27.33131 ? 617 HOH   A O   1 
HETATM 2496 O O   . HOH   C 3 .   ? -17.20906 -46.74295 16.21233  1.000 29.01526 ? 618 HOH   A O   1 
HETATM 2497 O O   . HOH   C 3 .   ? 2.40583   6.03363   -19.74752 1.000 21.32493 ? 619 HOH   A O   1 
HETATM 2498 O O   . HOH   C 3 .   ? -19.384   -48.911   26.925    1.000 17.59883 ? 620 HOH   A O   1 
HETATM 2499 O O   . HOH   C 3 .   ? 0.488     -16.535   -2.815    1.000 16.10309 ? 621 HOH   A O   1 
HETATM 2500 O O   . HOH   C 3 .   ? -27.87854 -28.65318 0.36999   1.000 18.48610 ? 622 HOH   A O   1 
HETATM 2501 O O   . HOH   C 3 .   ? 2.23588   -12.02519 -16.04395 1.000 23.05522 ? 623 HOH   A O   1 
HETATM 2502 O O   . HOH   C 3 .   ? -2.90708  -12.94263 6.74942   1.000 8.38584  ? 624 HOH   A O   1 
HETATM 2503 O O   . HOH   C 3 .   ? 2.588     -6.349    -0.823    1.000 20.20159 ? 625 HOH   A O   1 
HETATM 2504 O O   . HOH   C 3 .   ? -13.01542 -42.46059 18.29291  1.000 25.90443 ? 626 HOH   A O   1 
HETATM 2505 O O   . HOH   C 3 .   ? -19.87664 -34.68178 26.14639  1.000 27.84948 ? 627 HOH   A O   1 
HETATM 2506 O O   . HOH   C 3 .   ? -9.88204  4.63984   6.03830   1.000 11.95715 ? 628 HOH   A O   1 
HETATM 2507 O O   . HOH   C 3 .   ? 3.11292   -9.62793  -7.87947  1.000 11.17555 ? 629 HOH   A O   1 
HETATM 2508 O O   . HOH   C 3 .   ? -3.68983  -34.22908 9.61484   1.000 19.42652 ? 630 HOH   A O   1 
HETATM 2509 O O   . HOH   C 3 .   ? -24.77655 -26.32348 2.92415   1.000 13.94304 ? 631 HOH   A O   1 
HETATM 2510 O O   . HOH   C 3 .   ? -11.40046 6.78919   4.55390   1.000 23.42304 ? 632 HOH   A O   1 
HETATM 2511 O O   . HOH   C 3 .   ? -1.30602  -23.00684 22.55136  1.000 29.67115 ? 633 HOH   A O   1 
HETATM 2512 O O   . HOH   C 3 .   ? 2.83870   -3.28253  -28.29084 1.000 35.71922 ? 634 HOH   A O   1 
HETATM 2513 O O   . HOH   C 3 .   ? 4.12820   -9.28449  -11.86430 1.000 23.68599 ? 635 HOH   A O   1 
HETATM 2514 O O   . HOH   C 3 .   ? -21.82646 4.98404   -7.07622  1.000 24.68927 ? 636 HOH   A O   1 
HETATM 2515 O O   . HOH   C 3 .   ? -16.05085 -26.88032 -3.01116  1.000 20.03335 ? 637 HOH   A O   1 
HETATM 2516 O O   . HOH   C 3 .   ? -22.78883 4.34431   0.96056   1.000 14.56252 ? 638 HOH   A O   1 
HETATM 2517 O O   . HOH   C 3 .   ? -0.705    -23.143   14.556    1.000 14.85189 ? 639 HOH   A O   1 
HETATM 2518 O O   . HOH   C 3 .   ? -19.61238 -23.42587 -5.83967  1.000 17.20101 ? 640 HOH   A O   1 
HETATM 2519 O O   . HOH   C 3 .   ? -4.92289  2.75694   1.19471   1.000 20.92903 ? 641 HOH   A O   1 
HETATM 2520 O O   . HOH   C 3 .   ? 1.06948   -2.04514  -27.38147 1.000 21.27665 ? 642 HOH   A O   1 
HETATM 2521 O O   . HOH   C 3 .   ? -6.46223  -17.58124 10.22560  1.000 19.78182 ? 643 HOH   A O   1 
HETATM 2522 O O   . HOH   C 3 .   ? -10.52350 -9.55877  7.19657   1.000 14.25403 ? 644 HOH   A O   1 
HETATM 2523 O O   . HOH   C 3 .   ? -10.20062 -19.23044 10.20472  1.000 26.81788 ? 645 HOH   A O   1 
HETATM 2524 O O   . HOH   C 3 .   ? -20.57696 9.60019   -8.17086  1.000 22.04406 ? 646 HOH   A O   1 
HETATM 2525 O O   . HOH   C 3 .   ? -20.500   -49.436   29.477    1.000 21.42030 ? 647 HOH   A O   1 
HETATM 2526 O O   . HOH   C 3 .   ? -1.62869  -21.45343 3.55097   1.000 25.32818 ? 648 HOH   A O   1 
HETATM 2527 O O   . HOH   C 3 .   ? -20.66304 -37.61380 26.50490  1.000 22.12133 ? 649 HOH   A O   1 
HETATM 2528 O O   . HOH   C 3 .   ? -10.48014 -10.93099 8.81869   1.000 25.16429 ? 650 HOH   A O   1 
HETATM 2529 O O   . HOH   C 3 .   ? -17.14471 -24.16922 -8.37025  1.000 22.83623 ? 651 HOH   A O   1 
HETATM 2530 O O   . HOH   C 3 .   ? -4.396    -10.380   9.313     1.000 16.41715 ? 652 HOH   A O   1 
HETATM 2531 O O   . HOH   C 3 .   ? 2.55489   1.79272   -2.54613  1.000 29.98603 ? 653 HOH   A O   1 
HETATM 2532 O O   . HOH   C 3 .   ? -33.489   -26.745   4.429     1.000 19.64034 ? 654 HOH   A O   1 
HETATM 2533 O O   . HOH   C 3 .   ? -19.93647 14.94194  1.50536   1.000 24.37252 ? 655 HOH   A O   1 
HETATM 2534 O O   . HOH   C 3 .   ? -25.98080 -21.42877 0.00000   0.50  10.57708 ? 656 HOH   A O   1 
HETATM 2535 O O   . HOH   C 3 .   ? -27.07466 -23.95379 28.39109  1.000 25.87379 ? 657 HOH   A O   1 
HETATM 2536 O O   . HOH   C 3 .   ? -3.97984  4.91894   2.80408   1.000 28.64967 ? 658 HOH   A O   1 
HETATM 2537 O O   . HOH   C 3 .   ? -3.987    -13.713   10.040    1.000 12.73113 ? 659 HOH   A O   1 
HETATM 2538 O O   . HOH   C 3 .   ? -13.61747 -29.39421 27.85953  1.000 22.59658 ? 660 HOH   A O   1 
HETATM 2539 O O   . HOH   C 3 .   ? -27.94853 -21.72403 26.46553  1.000 26.05031 ? 661 HOH   A O   1 
HETATM 2540 O O   . HOH   C 3 .   ? -20.58028 14.14441  3.40331   1.000 23.63317 ? 662 HOH   A O   1 
# 
