data_9BVQ
# 
_entry.id   9BVQ 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BVQ         pdb_00009bvq 10.2210/pdb9bvq/pdb 
WWPDB D_1000284192 ?            ?                   
EMDB  EMD-44941    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-01-22 ? 
2 'Structure model' 1 1 2025-03-12 ? 
3 'Structure model' 1 2 2025-03-19 ? 
4 'Structure model' 1 3 2025-03-26 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Data collection'     
2 2 'Structure model' 'Database references' 
3 3 'Structure model' 'Data collection'     
4 4 'Structure model' 'Data collection'     
5 4 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
3 2 'Structure model' em_admin        
4 3 'Structure model' em_admin        
5 4 'Structure model' citation        
6 4 'Structure model' em_admin        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_ASTM'         
4  2 'Structure model' '_citation.journal_id_CSD'          
5  2 'Structure model' '_citation.journal_id_ISSN'         
6  2 'Structure model' '_citation.pdbx_database_id_DOI'    
7  2 'Structure model' '_citation.pdbx_database_id_PubMed' 
8  2 'Structure model' '_citation.title'                   
9  2 'Structure model' '_citation.year'                    
10 2 'Structure model' '_em_admin.last_update'             
11 3 'Structure model' '_em_admin.last_update'             
12 4 'Structure model' '_citation.journal_volume'          
13 4 'Structure model' '_citation.page_first'              
14 4 'Structure model' '_citation.page_last'               
15 4 'Structure model' '_citation.title'                   
16 4 'Structure model' '_em_admin.last_update'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BVQ 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-20 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Vitamin K-dependent gamma-carboxylase with TMG2 propeptide and glutamate-rich region' 
_pdbx_database_related.db_id          EMD-44941 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              weikai@wustl.edu 
_pdbx_contact_author.name_first         Weikai 
_pdbx_contact_author.name_last          Li 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-8711-1904 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Li, W.'  1 0000-0002-8711-1904 
'Liu, B.' 2 0000-0002-6581-780X 
'Cao, Q.' 3 0000-0003-2517-2231 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Nature 
_citation.journal_id_ASTM           NATUAS 
_citation.journal_id_CSD            0006 
_citation.journal_id_ISSN           1476-4687 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            639 
_citation.language                  ? 
_citation.page_first                816 
_citation.page_last                 824 
_citation.title                     'Molecular basis of vitamin-K-driven gamma-carboxylation at the membrane interface.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41586-025-08648-1 
_citation.pdbx_database_id_PubMed   39880037 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Cao, Q.'      1  0000-0003-2517-2231 
primary 'Ammerman, A.' 2  0000-0001-9245-4015 
primary 'Saimi, M.'    3  ?                   
primary 'Lin, Z.'      4  ?                   
primary 'Shen, G.'     5  0000-0002-5006-2790 
primary 'Chen, H.'     6  0000-0002-9835-5138 
primary 'Sun, J.'      7  0000-0001-8775-5032 
primary 'Chai, M.'     8  ?                   
primary 'Liu, S.'      9  ?                   
primary 'Hsu, F.F.'    10 ?                   
primary 'Krezel, A.M.' 11 ?                   
primary 'Gross, M.L.'  12 0000-0003-1159-4636 
primary 'Xu, J.'       13 0000-0002-2120-8287 
primary 'Garcia, B.A.' 14 0000-0003-3596-4750 
primary 'Liu, B.'      15 0000-0002-6581-780X 
primary 'Li, W.'       16 0000-0002-8711-1904 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Vitamin K-dependent gamma-carboxylase' 85005.680 1 4.1.1.90 ? ? ? 
2 polymer     man 'Transmembrane gamma-carboxyglutamic acid protein 2' 13399.892 1 ?        ? ? ? 
3 branched    man '2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose' 424.401   3 ?        ? 
? ? 
4 non-polymer syn 
'(4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE' 763.100   2 ? 
? ? ? 
5 non-polymer man 2-acetamido-2-deoxy-beta-D-glucopyranose 221.208   1 ?        ? ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 'Gamma-glutamyl carboxylase,Peptidyl-glutamate 4-carboxylase,Vitamin K gamma glutamyl carboxylase' 
2 'Proline-rich gamma-carboxyglutamic acid protein 2,Proline-rich Gla protein 2'                     
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;GPRQDSRIGKLLGFEWTDLSSWRRLVTLLNRPTDPASLAVFRFLFGFLMVLDIPQERGLSSLDRKYLDGLDVCRFPLLDA
LRPLPLDWMYLVYTIMFLGALGMMLGLCYRISCVLFLLPYWYVFLLDKTSWNNHSYLYGLLAFQLTFMDANHYWSVDGLL
NAHRRNAHVPLWNYAVLRGQIFIVYFIAGVKKLDADWVEGYSMEYLSRHWLFSPFKLLLSEELTSLLVVHWGGLLLDLSA
GFLLFFDVSRSIGLFFVSYFHCMNSQLFSIGMFSYVMLASSPLFCSPEWPRKLVSYCPRRLQQLLPLKAAPQPSVSCVYK
RSRGKSGQKPGLRHQLGAAFTLLYLLEQLFLPYSHFLTQGYNNWTNGLYGYSWDMMVHSRSHQHVKITYRDGRTGELGYL
NPGVFTQSRRWKDHADMLKQYATCLSRLLPKYNVTEPQIYFDIWVSINDRFQQRIFDPRVDIVQAAWSPFQRTSWVQPLL
MDLSPWRAKLQEIKSSLDNHTEVVFIADFPGLHLENFVSEDLGNTSIQLLQGEVTVELVAEQKNQTLREGEKMQLPAGEY
HKVYTTSPSPSCYMYVYVNTTELALEQDLAYLQELKEKVENGSETGPLPPELQPLLEGEVKGGPEPTPLVQTFLRRQQRL
QEIERRRNTPFHERFFRFLLRKLYVFRRSFLMTCISLRNLILGRPSLEQLAQEVTYANLRPFEAVGELNPSNTDSSHSNP
PESNPDPVHSEF
;
;GPRQDSRIGKLLGFEWTDLSSWRRLVTLLNRPTDPASLAVFRFLFGFLMVLDIPQERGLSSLDRKYLDGLDVCRFPLLDA
LRPLPLDWMYLVYTIMFLGALGMMLGLCYRISCVLFLLPYWYVFLLDKTSWNNHSYLYGLLAFQLTFMDANHYWSVDGLL
NAHRRNAHVPLWNYAVLRGQIFIVYFIAGVKKLDADWVEGYSMEYLSRHWLFSPFKLLLSEELTSLLVVHWGGLLLDLSA
GFLLFFDVSRSIGLFFVSYFHCMNSQLFSIGMFSYVMLASSPLFCSPEWPRKLVSYCPRRLQQLLPLKAAPQPSVSCVYK
RSRGKSGQKPGLRHQLGAAFTLLYLLEQLFLPYSHFLTQGYNNWTNGLYGYSWDMMVHSRSHQHVKITYRDGRTGELGYL
NPGVFTQSRRWKDHADMLKQYATCLSRLLPKYNVTEPQIYFDIWVSINDRFQQRIFDPRVDIVQAAWSPFQRTSWVQPLL
MDLSPWRAKLQEIKSSLDNHTEVVFIADFPGLHLENFVSEDLGNTSIQLLQGEVTVELVAEQKNQTLREGEKMQLPAGEY
HKVYTTSPSPSCYMYVYVNTTELALEQDLAYLQELKEKVENGSETGPLPPELQPLLEGEVKGGPEPTPLVQTFLRRQQRL
QEIERRRNTPFHERFFRFLLRKLYVFRRSFLMTCISLRNLILGRPSLEQLAQEVTYANLRPFEAVGELNPSNTDSSHSNP
PESNPDPVHSEF
;
A ? 
2 'polypeptide(L)' no no 
;EETDQEVFLGPPEAQSFLSSHTRIPRANHWDLELLTPGNLERECLEERCSWEEAREYFEDNTLTERFWESYIYNGKGGRG
RVDVASLAVGLTGGILLIVLAGLGAFWYLRWRQHRG
;
;EETDQEVFLGPPEAQSFLSSHTRIPRANHWDLELLTPGNLERECLEERCSWEEAREYFEDNTLTERFWESYIYNGKGGRG
RVDVASLAVGLTGGILLIVLAGLGAFWYLRWRQHRG
;
P ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
4 '(4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE' 6PL 
5 2-acetamido-2-deoxy-beta-D-glucopyranose                                                                             NAG 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PRO n 
1 3   ARG n 
1 4   GLN n 
1 5   ASP n 
1 6   SER n 
1 7   ARG n 
1 8   ILE n 
1 9   GLY n 
1 10  LYS n 
1 11  LEU n 
1 12  LEU n 
1 13  GLY n 
1 14  PHE n 
1 15  GLU n 
1 16  TRP n 
1 17  THR n 
1 18  ASP n 
1 19  LEU n 
1 20  SER n 
1 21  SER n 
1 22  TRP n 
1 23  ARG n 
1 24  ARG n 
1 25  LEU n 
1 26  VAL n 
1 27  THR n 
1 28  LEU n 
1 29  LEU n 
1 30  ASN n 
1 31  ARG n 
1 32  PRO n 
1 33  THR n 
1 34  ASP n 
1 35  PRO n 
1 36  ALA n 
1 37  SER n 
1 38  LEU n 
1 39  ALA n 
1 40  VAL n 
1 41  PHE n 
1 42  ARG n 
1 43  PHE n 
1 44  LEU n 
1 45  PHE n 
1 46  GLY n 
1 47  PHE n 
1 48  LEU n 
1 49  MET n 
1 50  VAL n 
1 51  LEU n 
1 52  ASP n 
1 53  ILE n 
1 54  PRO n 
1 55  GLN n 
1 56  GLU n 
1 57  ARG n 
1 58  GLY n 
1 59  LEU n 
1 60  SER n 
1 61  SER n 
1 62  LEU n 
1 63  ASP n 
1 64  ARG n 
1 65  LYS n 
1 66  TYR n 
1 67  LEU n 
1 68  ASP n 
1 69  GLY n 
1 70  LEU n 
1 71  ASP n 
1 72  VAL n 
1 73  CYS n 
1 74  ARG n 
1 75  PHE n 
1 76  PRO n 
1 77  LEU n 
1 78  LEU n 
1 79  ASP n 
1 80  ALA n 
1 81  LEU n 
1 82  ARG n 
1 83  PRO n 
1 84  LEU n 
1 85  PRO n 
1 86  LEU n 
1 87  ASP n 
1 88  TRP n 
1 89  MET n 
1 90  TYR n 
1 91  LEU n 
1 92  VAL n 
1 93  TYR n 
1 94  THR n 
1 95  ILE n 
1 96  MET n 
1 97  PHE n 
1 98  LEU n 
1 99  GLY n 
1 100 ALA n 
1 101 LEU n 
1 102 GLY n 
1 103 MET n 
1 104 MET n 
1 105 LEU n 
1 106 GLY n 
1 107 LEU n 
1 108 CYS n 
1 109 TYR n 
1 110 ARG n 
1 111 ILE n 
1 112 SER n 
1 113 CYS n 
1 114 VAL n 
1 115 LEU n 
1 116 PHE n 
1 117 LEU n 
1 118 LEU n 
1 119 PRO n 
1 120 TYR n 
1 121 TRP n 
1 122 TYR n 
1 123 VAL n 
1 124 PHE n 
1 125 LEU n 
1 126 LEU n 
1 127 ASP n 
1 128 LYS n 
1 129 THR n 
1 130 SER n 
1 131 TRP n 
1 132 ASN n 
1 133 ASN n 
1 134 HIS n 
1 135 SER n 
1 136 TYR n 
1 137 LEU n 
1 138 TYR n 
1 139 GLY n 
1 140 LEU n 
1 141 LEU n 
1 142 ALA n 
1 143 PHE n 
1 144 GLN n 
1 145 LEU n 
1 146 THR n 
1 147 PHE n 
1 148 MET n 
1 149 ASP n 
1 150 ALA n 
1 151 ASN n 
1 152 HIS n 
1 153 TYR n 
1 154 TRP n 
1 155 SER n 
1 156 VAL n 
1 157 ASP n 
1 158 GLY n 
1 159 LEU n 
1 160 LEU n 
1 161 ASN n 
1 162 ALA n 
1 163 HIS n 
1 164 ARG n 
1 165 ARG n 
1 166 ASN n 
1 167 ALA n 
1 168 HIS n 
1 169 VAL n 
1 170 PRO n 
1 171 LEU n 
1 172 TRP n 
1 173 ASN n 
1 174 TYR n 
1 175 ALA n 
1 176 VAL n 
1 177 LEU n 
1 178 ARG n 
1 179 GLY n 
1 180 GLN n 
1 181 ILE n 
1 182 PHE n 
1 183 ILE n 
1 184 VAL n 
1 185 TYR n 
1 186 PHE n 
1 187 ILE n 
1 188 ALA n 
1 189 GLY n 
1 190 VAL n 
1 191 LYS n 
1 192 LYS n 
1 193 LEU n 
1 194 ASP n 
1 195 ALA n 
1 196 ASP n 
1 197 TRP n 
1 198 VAL n 
1 199 GLU n 
1 200 GLY n 
1 201 TYR n 
1 202 SER n 
1 203 MET n 
1 204 GLU n 
1 205 TYR n 
1 206 LEU n 
1 207 SER n 
1 208 ARG n 
1 209 HIS n 
1 210 TRP n 
1 211 LEU n 
1 212 PHE n 
1 213 SER n 
1 214 PRO n 
1 215 PHE n 
1 216 LYS n 
1 217 LEU n 
1 218 LEU n 
1 219 LEU n 
1 220 SER n 
1 221 GLU n 
1 222 GLU n 
1 223 LEU n 
1 224 THR n 
1 225 SER n 
1 226 LEU n 
1 227 LEU n 
1 228 VAL n 
1 229 VAL n 
1 230 HIS n 
1 231 TRP n 
1 232 GLY n 
1 233 GLY n 
1 234 LEU n 
1 235 LEU n 
1 236 LEU n 
1 237 ASP n 
1 238 LEU n 
1 239 SER n 
1 240 ALA n 
1 241 GLY n 
1 242 PHE n 
1 243 LEU n 
1 244 LEU n 
1 245 PHE n 
1 246 PHE n 
1 247 ASP n 
1 248 VAL n 
1 249 SER n 
1 250 ARG n 
1 251 SER n 
1 252 ILE n 
1 253 GLY n 
1 254 LEU n 
1 255 PHE n 
1 256 PHE n 
1 257 VAL n 
1 258 SER n 
1 259 TYR n 
1 260 PHE n 
1 261 HIS n 
1 262 CYS n 
1 263 MET n 
1 264 ASN n 
1 265 SER n 
1 266 GLN n 
1 267 LEU n 
1 268 PHE n 
1 269 SER n 
1 270 ILE n 
1 271 GLY n 
1 272 MET n 
1 273 PHE n 
1 274 SER n 
1 275 TYR n 
1 276 VAL n 
1 277 MET n 
1 278 LEU n 
1 279 ALA n 
1 280 SER n 
1 281 SER n 
1 282 PRO n 
1 283 LEU n 
1 284 PHE n 
1 285 CYS n 
1 286 SER n 
1 287 PRO n 
1 288 GLU n 
1 289 TRP n 
1 290 PRO n 
1 291 ARG n 
1 292 LYS n 
1 293 LEU n 
1 294 VAL n 
1 295 SER n 
1 296 TYR n 
1 297 CYS n 
1 298 PRO n 
1 299 ARG n 
1 300 ARG n 
1 301 LEU n 
1 302 GLN n 
1 303 GLN n 
1 304 LEU n 
1 305 LEU n 
1 306 PRO n 
1 307 LEU n 
1 308 LYS n 
1 309 ALA n 
1 310 ALA n 
1 311 PRO n 
1 312 GLN n 
1 313 PRO n 
1 314 SER n 
1 315 VAL n 
1 316 SER n 
1 317 CYS n 
1 318 VAL n 
1 319 TYR n 
1 320 LYS n 
1 321 ARG n 
1 322 SER n 
1 323 ARG n 
1 324 GLY n 
1 325 LYS n 
1 326 SER n 
1 327 GLY n 
1 328 GLN n 
1 329 LYS n 
1 330 PRO n 
1 331 GLY n 
1 332 LEU n 
1 333 ARG n 
1 334 HIS n 
1 335 GLN n 
1 336 LEU n 
1 337 GLY n 
1 338 ALA n 
1 339 ALA n 
1 340 PHE n 
1 341 THR n 
1 342 LEU n 
1 343 LEU n 
1 344 TYR n 
1 345 LEU n 
1 346 LEU n 
1 347 GLU n 
1 348 GLN n 
1 349 LEU n 
1 350 PHE n 
1 351 LEU n 
1 352 PRO n 
1 353 TYR n 
1 354 SER n 
1 355 HIS n 
1 356 PHE n 
1 357 LEU n 
1 358 THR n 
1 359 GLN n 
1 360 GLY n 
1 361 TYR n 
1 362 ASN n 
1 363 ASN n 
1 364 TRP n 
1 365 THR n 
1 366 ASN n 
1 367 GLY n 
1 368 LEU n 
1 369 TYR n 
1 370 GLY n 
1 371 TYR n 
1 372 SER n 
1 373 TRP n 
1 374 ASP n 
1 375 MET n 
1 376 MET n 
1 377 VAL n 
1 378 HIS n 
1 379 SER n 
1 380 ARG n 
1 381 SER n 
1 382 HIS n 
1 383 GLN n 
1 384 HIS n 
1 385 VAL n 
1 386 LYS n 
1 387 ILE n 
1 388 THR n 
1 389 TYR n 
1 390 ARG n 
1 391 ASP n 
1 392 GLY n 
1 393 ARG n 
1 394 THR n 
1 395 GLY n 
1 396 GLU n 
1 397 LEU n 
1 398 GLY n 
1 399 TYR n 
1 400 LEU n 
1 401 ASN n 
1 402 PRO n 
1 403 GLY n 
1 404 VAL n 
1 405 PHE n 
1 406 THR n 
1 407 GLN n 
1 408 SER n 
1 409 ARG n 
1 410 ARG n 
1 411 TRP n 
1 412 LYS n 
1 413 ASP n 
1 414 HIS n 
1 415 ALA n 
1 416 ASP n 
1 417 MET n 
1 418 LEU n 
1 419 LYS n 
1 420 GLN n 
1 421 TYR n 
1 422 ALA n 
1 423 THR n 
1 424 CYS n 
1 425 LEU n 
1 426 SER n 
1 427 ARG n 
1 428 LEU n 
1 429 LEU n 
1 430 PRO n 
1 431 LYS n 
1 432 TYR n 
1 433 ASN n 
1 434 VAL n 
1 435 THR n 
1 436 GLU n 
1 437 PRO n 
1 438 GLN n 
1 439 ILE n 
1 440 TYR n 
1 441 PHE n 
1 442 ASP n 
1 443 ILE n 
1 444 TRP n 
1 445 VAL n 
1 446 SER n 
1 447 ILE n 
1 448 ASN n 
1 449 ASP n 
1 450 ARG n 
1 451 PHE n 
1 452 GLN n 
1 453 GLN n 
1 454 ARG n 
1 455 ILE n 
1 456 PHE n 
1 457 ASP n 
1 458 PRO n 
1 459 ARG n 
1 460 VAL n 
1 461 ASP n 
1 462 ILE n 
1 463 VAL n 
1 464 GLN n 
1 465 ALA n 
1 466 ALA n 
1 467 TRP n 
1 468 SER n 
1 469 PRO n 
1 470 PHE n 
1 471 GLN n 
1 472 ARG n 
1 473 THR n 
1 474 SER n 
1 475 TRP n 
1 476 VAL n 
1 477 GLN n 
1 478 PRO n 
1 479 LEU n 
1 480 LEU n 
1 481 MET n 
1 482 ASP n 
1 483 LEU n 
1 484 SER n 
1 485 PRO n 
1 486 TRP n 
1 487 ARG n 
1 488 ALA n 
1 489 LYS n 
1 490 LEU n 
1 491 GLN n 
1 492 GLU n 
1 493 ILE n 
1 494 LYS n 
1 495 SER n 
1 496 SER n 
1 497 LEU n 
1 498 ASP n 
1 499 ASN n 
1 500 HIS n 
1 501 THR n 
1 502 GLU n 
1 503 VAL n 
1 504 VAL n 
1 505 PHE n 
1 506 ILE n 
1 507 ALA n 
1 508 ASP n 
1 509 PHE n 
1 510 PRO n 
1 511 GLY n 
1 512 LEU n 
1 513 HIS n 
1 514 LEU n 
1 515 GLU n 
1 516 ASN n 
1 517 PHE n 
1 518 VAL n 
1 519 SER n 
1 520 GLU n 
1 521 ASP n 
1 522 LEU n 
1 523 GLY n 
1 524 ASN n 
1 525 THR n 
1 526 SER n 
1 527 ILE n 
1 528 GLN n 
1 529 LEU n 
1 530 LEU n 
1 531 GLN n 
1 532 GLY n 
1 533 GLU n 
1 534 VAL n 
1 535 THR n 
1 536 VAL n 
1 537 GLU n 
1 538 LEU n 
1 539 VAL n 
1 540 ALA n 
1 541 GLU n 
1 542 GLN n 
1 543 LYS n 
1 544 ASN n 
1 545 GLN n 
1 546 THR n 
1 547 LEU n 
1 548 ARG n 
1 549 GLU n 
1 550 GLY n 
1 551 GLU n 
1 552 LYS n 
1 553 MET n 
1 554 GLN n 
1 555 LEU n 
1 556 PRO n 
1 557 ALA n 
1 558 GLY n 
1 559 GLU n 
1 560 TYR n 
1 561 HIS n 
1 562 LYS n 
1 563 VAL n 
1 564 TYR n 
1 565 THR n 
1 566 THR n 
1 567 SER n 
1 568 PRO n 
1 569 SER n 
1 570 PRO n 
1 571 SER n 
1 572 CYS n 
1 573 TYR n 
1 574 MET n 
1 575 TYR n 
1 576 VAL n 
1 577 TYR n 
1 578 VAL n 
1 579 ASN n 
1 580 THR n 
1 581 THR n 
1 582 GLU n 
1 583 LEU n 
1 584 ALA n 
1 585 LEU n 
1 586 GLU n 
1 587 GLN n 
1 588 ASP n 
1 589 LEU n 
1 590 ALA n 
1 591 TYR n 
1 592 LEU n 
1 593 GLN n 
1 594 GLU n 
1 595 LEU n 
1 596 LYS n 
1 597 GLU n 
1 598 LYS n 
1 599 VAL n 
1 600 GLU n 
1 601 ASN n 
1 602 GLY n 
1 603 SER n 
1 604 GLU n 
1 605 THR n 
1 606 GLY n 
1 607 PRO n 
1 608 LEU n 
1 609 PRO n 
1 610 PRO n 
1 611 GLU n 
1 612 LEU n 
1 613 GLN n 
1 614 PRO n 
1 615 LEU n 
1 616 LEU n 
1 617 GLU n 
1 618 GLY n 
1 619 GLU n 
1 620 VAL n 
1 621 LYS n 
1 622 GLY n 
1 623 GLY n 
1 624 PRO n 
1 625 GLU n 
1 626 PRO n 
1 627 THR n 
1 628 PRO n 
1 629 LEU n 
1 630 VAL n 
1 631 GLN n 
1 632 THR n 
1 633 PHE n 
1 634 LEU n 
1 635 ARG n 
1 636 ARG n 
1 637 GLN n 
1 638 GLN n 
1 639 ARG n 
1 640 LEU n 
1 641 GLN n 
1 642 GLU n 
1 643 ILE n 
1 644 GLU n 
1 645 ARG n 
1 646 ARG n 
1 647 ARG n 
1 648 ASN n 
1 649 THR n 
1 650 PRO n 
1 651 PHE n 
1 652 HIS n 
1 653 GLU n 
1 654 ARG n 
1 655 PHE n 
1 656 PHE n 
1 657 ARG n 
1 658 PHE n 
1 659 LEU n 
1 660 LEU n 
1 661 ARG n 
1 662 LYS n 
1 663 LEU n 
1 664 TYR n 
1 665 VAL n 
1 666 PHE n 
1 667 ARG n 
1 668 ARG n 
1 669 SER n 
1 670 PHE n 
1 671 LEU n 
1 672 MET n 
1 673 THR n 
1 674 CYS n 
1 675 ILE n 
1 676 SER n 
1 677 LEU n 
1 678 ARG n 
1 679 ASN n 
1 680 LEU n 
1 681 ILE n 
1 682 LEU n 
1 683 GLY n 
1 684 ARG n 
1 685 PRO n 
1 686 SER n 
1 687 LEU n 
1 688 GLU n 
1 689 GLN n 
1 690 LEU n 
1 691 ALA n 
1 692 GLN n 
1 693 GLU n 
1 694 VAL n 
1 695 THR n 
1 696 TYR n 
1 697 ALA n 
1 698 ASN n 
1 699 LEU n 
1 700 ARG n 
1 701 PRO n 
1 702 PHE n 
1 703 GLU n 
1 704 ALA n 
1 705 VAL n 
1 706 GLY n 
1 707 GLU n 
1 708 LEU n 
1 709 ASN n 
1 710 PRO n 
1 711 SER n 
1 712 ASN n 
1 713 THR n 
1 714 ASP n 
1 715 SER n 
1 716 SER n 
1 717 HIS n 
1 718 SER n 
1 719 ASN n 
1 720 PRO n 
1 721 PRO n 
1 722 GLU n 
1 723 SER n 
1 724 ASN n 
1 725 PRO n 
1 726 ASP n 
1 727 PRO n 
1 728 VAL n 
1 729 HIS n 
1 730 SER n 
1 731 GLU n 
1 732 PHE n 
2 1   GLU n 
2 2   GLU n 
2 3   THR n 
2 4   ASP n 
2 5   GLN n 
2 6   GLU n 
2 7   VAL n 
2 8   PHE n 
2 9   LEU n 
2 10  GLY n 
2 11  PRO n 
2 12  PRO n 
2 13  GLU n 
2 14  ALA n 
2 15  GLN n 
2 16  SER n 
2 17  PHE n 
2 18  LEU n 
2 19  SER n 
2 20  SER n 
2 21  HIS n 
2 22  THR n 
2 23  ARG n 
2 24  ILE n 
2 25  PRO n 
2 26  ARG n 
2 27  ALA n 
2 28  ASN n 
2 29  HIS n 
2 30  TRP n 
2 31  ASP n 
2 32  LEU n 
2 33  GLU n 
2 34  LEU n 
2 35  LEU n 
2 36  THR n 
2 37  PRO n 
2 38  GLY n 
2 39  ASN n 
2 40  LEU n 
2 41  GLU n 
2 42  ARG n 
2 43  GLU n 
2 44  CYS n 
2 45  LEU n 
2 46  GLU n 
2 47  GLU n 
2 48  ARG n 
2 49  CYS n 
2 50  SER n 
2 51  TRP n 
2 52  GLU n 
2 53  GLU n 
2 54  ALA n 
2 55  ARG n 
2 56  GLU n 
2 57  TYR n 
2 58  PHE n 
2 59  GLU n 
2 60  ASP n 
2 61  ASN n 
2 62  THR n 
2 63  LEU n 
2 64  THR n 
2 65  GLU n 
2 66  ARG n 
2 67  PHE n 
2 68  TRP n 
2 69  GLU n 
2 70  SER n 
2 71  TYR n 
2 72  ILE n 
2 73  TYR n 
2 74  ASN n 
2 75  GLY n 
2 76  LYS n 
2 77  GLY n 
2 78  GLY n 
2 79  ARG n 
2 80  GLY n 
2 81  ARG n 
2 82  VAL n 
2 83  ASP n 
2 84  VAL n 
2 85  ALA n 
2 86  SER n 
2 87  LEU n 
2 88  ALA n 
2 89  VAL n 
2 90  GLY n 
2 91  LEU n 
2 92  THR n 
2 93  GLY n 
2 94  GLY n 
2 95  ILE n 
2 96  LEU n 
2 97  LEU n 
2 98  ILE n 
2 99  VAL n 
2 100 LEU n 
2 101 ALA n 
2 102 GLY n 
2 103 LEU n 
2 104 GLY n 
2 105 ALA n 
2 106 PHE n 
2 107 TRP n 
2 108 TYR n 
2 109 LEU n 
2 110 ARG n 
2 111 TRP n 
2 112 ARG n 
2 113 GLN n 
2 114 HIS n 
2 115 ARG n 
2 116 GLY n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 732 human ? 'GGCX, GC'           ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'Homo sapiens' 
9606 ? ? ? ? ? ? ? ? HEK293S ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 116 human ? 'PRRG2, PRGP2, TMG2' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'Homo sapiens' 
9606 ? ? ? ? ? ? ? ? HEK293S ? ? ? ? ? ? ? ? ? ? ? ? 
# 
_pdbx_entity_branch.entity_id   3 
_pdbx_entity_branch.type        oligosaccharide 
# 
loop_
_pdbx_entity_branch_descriptor.ordinal 
_pdbx_entity_branch_descriptor.entity_id 
_pdbx_entity_branch_descriptor.descriptor 
_pdbx_entity_branch_descriptor.type 
_pdbx_entity_branch_descriptor.program 
_pdbx_entity_branch_descriptor.program_version 
1 3 DGlcpNAcb1-4DGlcpNAcb1-ROH                            'Glycam Condensed Sequence' GMML       1.0   
2 3 'WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*NCC/3=O]/1-1/a4-b1' WURCS                       PDB2Glycan 1.1.0 
3 3 '[][D-1-deoxy-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{}}'       LINUCS                      PDB-CARE   ?     
# 
_pdbx_entity_branch_link.link_id                    1 
_pdbx_entity_branch_link.entity_id                  3 
_pdbx_entity_branch_link.entity_branch_list_num_1   2 
_pdbx_entity_branch_link.comp_id_1                  NAG 
_pdbx_entity_branch_link.atom_id_1                  C1 
_pdbx_entity_branch_link.leaving_atom_id_1          O1 
_pdbx_entity_branch_link.entity_branch_list_num_2   1 
_pdbx_entity_branch_link.comp_id_2                  NAG 
_pdbx_entity_branch_link.atom_id_2                  O4 
_pdbx_entity_branch_link.leaving_atom_id_2          HO4 
_pdbx_entity_branch_link.value_order                sing 
_pdbx_entity_branch_link.details                    ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
6PL non-polymer                  . 
'(4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE' 
1-PALMITOYL-2-STEAROYL-SN-GLYCERO-3-PHOSPHOCHOLINE 'C42 H85 N O8 P 1' 763.100 
ALA 'L-peptide linking'          y ALANINE ? 'C3 H7 N O2'       89.093  
ARG 'L-peptide linking'          y ARGININE ? 'C6 H15 N4 O2 1'   175.209 
ASN 'L-peptide linking'          y ASPARAGINE ? 'C4 H8 N2 O3'      132.118 
ASP 'L-peptide linking'          y 'ASPARTIC ACID' ? 'C4 H7 N O4'       133.103 
CYS 'L-peptide linking'          y CYSTEINE ? 'C3 H7 N O2 S'     121.158 
GLN 'L-peptide linking'          y GLUTAMINE ? 'C5 H10 N2 O3'     146.144 
GLU 'L-peptide linking'          y 'GLUTAMIC ACID' ? 'C5 H9 N O4'       147.129 
GLY 'peptide linking'            y GLYCINE ? 'C2 H5 N O2'       75.067  
HIS 'L-peptide linking'          y HISTIDINE ? 'C6 H10 N3 O2 1'   156.162 
ILE 'L-peptide linking'          y ISOLEUCINE ? 'C6 H13 N O2'      131.173 
LEU 'L-peptide linking'          y LEUCINE ? 'C6 H13 N O2'      131.173 
LYS 'L-peptide linking'          y LYSINE ? 'C6 H15 N2 O2 1'   147.195 
MET 'L-peptide linking'          y METHIONINE ? 'C5 H11 N O2 S'    149.211 
NAG 'D-saccharide, beta linking' . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'      221.208 
PHE 'L-peptide linking'          y PHENYLALANINE ? 'C9 H11 N O2'      165.189 
PRO 'L-peptide linking'          y PROLINE ? 'C5 H9 N O2'       115.130 
SER 'L-peptide linking'          y SERINE ? 'C3 H7 N O3'       105.093 
THR 'L-peptide linking'          y THREONINE ? 'C4 H9 N O3'       119.119 
TRP 'L-peptide linking'          y TRYPTOPHAN ? 'C11 H12 N2 O2'    204.225 
TYR 'L-peptide linking'          y TYROSINE ? 'C9 H11 N O3'      181.189 
VAL 'L-peptide linking'          y VALINE ? 'C5 H11 N O2'      117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   27  ?   ?   ?   A . n 
A 1 2   PRO 2   28  ?   ?   ?   A . n 
A 1 3   ARG 3   29  ?   ?   ?   A . n 
A 1 4   GLN 4   30  ?   ?   ?   A . n 
A 1 5   ASP 5   31  31  ASP ASP A . n 
A 1 6   SER 6   32  32  SER SER A . n 
A 1 7   ARG 7   33  33  ARG ARG A . n 
A 1 8   ILE 8   34  34  ILE ILE A . n 
A 1 9   GLY 9   35  35  GLY GLY A . n 
A 1 10  LYS 10  36  36  LYS LYS A . n 
A 1 11  LEU 11  37  37  LEU LEU A . n 
A 1 12  LEU 12  38  38  LEU LEU A . n 
A 1 13  GLY 13  39  39  GLY GLY A . n 
A 1 14  PHE 14  40  40  PHE PHE A . n 
A 1 15  GLU 15  41  41  GLU GLU A . n 
A 1 16  TRP 16  42  42  TRP TRP A . n 
A 1 17  THR 17  43  43  THR THR A . n 
A 1 18  ASP 18  44  44  ASP ASP A . n 
A 1 19  LEU 19  45  45  LEU LEU A . n 
A 1 20  SER 20  46  46  SER SER A . n 
A 1 21  SER 21  47  47  SER SER A . n 
A 1 22  TRP 22  48  48  TRP TRP A . n 
A 1 23  ARG 23  49  49  ARG ARG A . n 
A 1 24  ARG 24  50  50  ARG ARG A . n 
A 1 25  LEU 25  51  51  LEU LEU A . n 
A 1 26  VAL 26  52  52  VAL VAL A . n 
A 1 27  THR 27  53  53  THR THR A . n 
A 1 28  LEU 28  54  54  LEU LEU A . n 
A 1 29  LEU 29  55  55  LEU LEU A . n 
A 1 30  ASN 30  56  56  ASN ASN A . n 
A 1 31  ARG 31  57  57  ARG ARG A . n 
A 1 32  PRO 32  58  58  PRO PRO A . n 
A 1 33  THR 33  59  59  THR THR A . n 
A 1 34  ASP 34  60  60  ASP ASP A . n 
A 1 35  PRO 35  61  61  PRO PRO A . n 
A 1 36  ALA 36  62  62  ALA ALA A . n 
A 1 37  SER 37  63  63  SER SER A . n 
A 1 38  LEU 38  64  64  LEU LEU A . n 
A 1 39  ALA 39  65  65  ALA ALA A . n 
A 1 40  VAL 40  66  66  VAL VAL A . n 
A 1 41  PHE 41  67  67  PHE PHE A . n 
A 1 42  ARG 42  68  68  ARG ARG A . n 
A 1 43  PHE 43  69  69  PHE PHE A . n 
A 1 44  LEU 44  70  70  LEU LEU A . n 
A 1 45  PHE 45  71  71  PHE PHE A . n 
A 1 46  GLY 46  72  72  GLY GLY A . n 
A 1 47  PHE 47  73  73  PHE PHE A . n 
A 1 48  LEU 48  74  74  LEU LEU A . n 
A 1 49  MET 49  75  75  MET MET A . n 
A 1 50  VAL 50  76  76  VAL VAL A . n 
A 1 51  LEU 51  77  77  LEU LEU A . n 
A 1 52  ASP 52  78  78  ASP ASP A . n 
A 1 53  ILE 53  79  79  ILE ILE A . n 
A 1 54  PRO 54  80  80  PRO PRO A . n 
A 1 55  GLN 55  81  81  GLN GLN A . n 
A 1 56  GLU 56  82  82  GLU GLU A . n 
A 1 57  ARG 57  83  83  ARG ARG A . n 
A 1 58  GLY 58  84  84  GLY GLY A . n 
A 1 59  LEU 59  85  85  LEU LEU A . n 
A 1 60  SER 60  86  86  SER SER A . n 
A 1 61  SER 61  87  87  SER SER A . n 
A 1 62  LEU 62  88  88  LEU LEU A . n 
A 1 63  ASP 63  89  89  ASP ASP A . n 
A 1 64  ARG 64  90  90  ARG ARG A . n 
A 1 65  LYS 65  91  91  LYS LYS A . n 
A 1 66  TYR 66  92  92  TYR TYR A . n 
A 1 67  LEU 67  93  93  LEU LEU A . n 
A 1 68  ASP 68  94  94  ASP ASP A . n 
A 1 69  GLY 69  95  95  GLY GLY A . n 
A 1 70  LEU 70  96  96  LEU LEU A . n 
A 1 71  ASP 71  97  97  ASP ASP A . n 
A 1 72  VAL 72  98  98  VAL VAL A . n 
A 1 73  CYS 73  99  99  CYS CYS A . n 
A 1 74  ARG 74  100 100 ARG ARG A . n 
A 1 75  PHE 75  101 101 PHE PHE A . n 
A 1 76  PRO 76  102 102 PRO PRO A . n 
A 1 77  LEU 77  103 103 LEU LEU A . n 
A 1 78  LEU 78  104 104 LEU LEU A . n 
A 1 79  ASP 79  105 105 ASP ASP A . n 
A 1 80  ALA 80  106 106 ALA ALA A . n 
A 1 81  LEU 81  107 107 LEU LEU A . n 
A 1 82  ARG 82  108 108 ARG ARG A . n 
A 1 83  PRO 83  109 109 PRO PRO A . n 
A 1 84  LEU 84  110 110 LEU LEU A . n 
A 1 85  PRO 85  111 111 PRO PRO A . n 
A 1 86  LEU 86  112 112 LEU LEU A . n 
A 1 87  ASP 87  113 113 ASP ASP A . n 
A 1 88  TRP 88  114 114 TRP TRP A . n 
A 1 89  MET 89  115 115 MET MET A . n 
A 1 90  TYR 90  116 116 TYR TYR A . n 
A 1 91  LEU 91  117 117 LEU LEU A . n 
A 1 92  VAL 92  118 118 VAL VAL A . n 
A 1 93  TYR 93  119 119 TYR TYR A . n 
A 1 94  THR 94  120 120 THR THR A . n 
A 1 95  ILE 95  121 121 ILE ILE A . n 
A 1 96  MET 96  122 122 MET MET A . n 
A 1 97  PHE 97  123 123 PHE PHE A . n 
A 1 98  LEU 98  124 124 LEU LEU A . n 
A 1 99  GLY 99  125 125 GLY GLY A . n 
A 1 100 ALA 100 126 126 ALA ALA A . n 
A 1 101 LEU 101 127 127 LEU LEU A . n 
A 1 102 GLY 102 128 128 GLY GLY A . n 
A 1 103 MET 103 129 129 MET MET A . n 
A 1 104 MET 104 130 130 MET MET A . n 
A 1 105 LEU 105 131 131 LEU LEU A . n 
A 1 106 GLY 106 132 132 GLY GLY A . n 
A 1 107 LEU 107 133 133 LEU LEU A . n 
A 1 108 CYS 108 134 134 CYS CYS A . n 
A 1 109 TYR 109 135 135 TYR TYR A . n 
A 1 110 ARG 110 136 136 ARG ARG A . n 
A 1 111 ILE 111 137 137 ILE ILE A . n 
A 1 112 SER 112 138 138 SER SER A . n 
A 1 113 CYS 113 139 139 CYS CYS A . n 
A 1 114 VAL 114 140 140 VAL VAL A . n 
A 1 115 LEU 115 141 141 LEU LEU A . n 
A 1 116 PHE 116 142 142 PHE PHE A . n 
A 1 117 LEU 117 143 143 LEU LEU A . n 
A 1 118 LEU 118 144 144 LEU LEU A . n 
A 1 119 PRO 119 145 145 PRO PRO A . n 
A 1 120 TYR 120 146 146 TYR TYR A . n 
A 1 121 TRP 121 147 147 TRP TRP A . n 
A 1 122 TYR 122 148 148 TYR TYR A . n 
A 1 123 VAL 123 149 149 VAL VAL A . n 
A 1 124 PHE 124 150 150 PHE PHE A . n 
A 1 125 LEU 125 151 151 LEU LEU A . n 
A 1 126 LEU 126 152 152 LEU LEU A . n 
A 1 127 ASP 127 153 153 ASP ASP A . n 
A 1 128 LYS 128 154 154 LYS LYS A . n 
A 1 129 THR 129 155 155 THR THR A . n 
A 1 130 SER 130 156 156 SER SER A . n 
A 1 131 TRP 131 157 157 TRP TRP A . n 
A 1 132 ASN 132 158 158 ASN ASN A . n 
A 1 133 ASN 133 159 159 ASN ASN A . n 
A 1 134 HIS 134 160 160 HIS HIS A . n 
A 1 135 SER 135 161 161 SER SER A . n 
A 1 136 TYR 136 162 162 TYR TYR A . n 
A 1 137 LEU 137 163 163 LEU LEU A . n 
A 1 138 TYR 138 164 164 TYR TYR A . n 
A 1 139 GLY 139 165 165 GLY GLY A . n 
A 1 140 LEU 140 166 166 LEU LEU A . n 
A 1 141 LEU 141 167 167 LEU LEU A . n 
A 1 142 ALA 142 168 168 ALA ALA A . n 
A 1 143 PHE 143 169 169 PHE PHE A . n 
A 1 144 GLN 144 170 170 GLN GLN A . n 
A 1 145 LEU 145 171 171 LEU LEU A . n 
A 1 146 THR 146 172 172 THR THR A . n 
A 1 147 PHE 147 173 173 PHE PHE A . n 
A 1 148 MET 148 174 174 MET MET A . n 
A 1 149 ASP 149 175 175 ASP ASP A . n 
A 1 150 ALA 150 176 176 ALA ALA A . n 
A 1 151 ASN 151 177 177 ASN ASN A . n 
A 1 152 HIS 152 178 178 HIS HIS A . n 
A 1 153 TYR 153 179 179 TYR TYR A . n 
A 1 154 TRP 154 180 180 TRP TRP A . n 
A 1 155 SER 155 181 181 SER SER A . n 
A 1 156 VAL 156 182 182 VAL VAL A . n 
A 1 157 ASP 157 183 183 ASP ASP A . n 
A 1 158 GLY 158 184 184 GLY GLY A . n 
A 1 159 LEU 159 185 185 LEU LEU A . n 
A 1 160 LEU 160 186 186 LEU LEU A . n 
A 1 161 ASN 161 187 187 ASN ASN A . n 
A 1 162 ALA 162 188 188 ALA ALA A . n 
A 1 163 HIS 163 189 189 HIS HIS A . n 
A 1 164 ARG 164 190 190 ARG ARG A . n 
A 1 165 ARG 165 191 191 ARG ARG A . n 
A 1 166 ASN 166 192 192 ASN ASN A . n 
A 1 167 ALA 167 193 193 ALA ALA A . n 
A 1 168 HIS 168 194 194 HIS HIS A . n 
A 1 169 VAL 169 195 195 VAL VAL A . n 
A 1 170 PRO 170 196 196 PRO PRO A . n 
A 1 171 LEU 171 197 197 LEU LEU A . n 
A 1 172 TRP 172 198 198 TRP TRP A . n 
A 1 173 ASN 173 199 199 ASN ASN A . n 
A 1 174 TYR 174 200 200 TYR TYR A . n 
A 1 175 ALA 175 201 201 ALA ALA A . n 
A 1 176 VAL 176 202 202 VAL VAL A . n 
A 1 177 LEU 177 203 203 LEU LEU A . n 
A 1 178 ARG 178 204 204 ARG ARG A . n 
A 1 179 GLY 179 205 205 GLY GLY A . n 
A 1 180 GLN 180 206 206 GLN GLN A . n 
A 1 181 ILE 181 207 207 ILE ILE A . n 
A 1 182 PHE 182 208 208 PHE PHE A . n 
A 1 183 ILE 183 209 209 ILE ILE A . n 
A 1 184 VAL 184 210 210 VAL VAL A . n 
A 1 185 TYR 185 211 211 TYR TYR A . n 
A 1 186 PHE 186 212 212 PHE PHE A . n 
A 1 187 ILE 187 213 213 ILE ILE A . n 
A 1 188 ALA 188 214 214 ALA ALA A . n 
A 1 189 GLY 189 215 215 GLY GLY A . n 
A 1 190 VAL 190 216 216 VAL VAL A . n 
A 1 191 LYS 191 217 217 LYS LYS A . n 
A 1 192 LYS 192 218 218 LYS LYS A . n 
A 1 193 LEU 193 219 219 LEU LEU A . n 
A 1 194 ASP 194 220 220 ASP ASP A . n 
A 1 195 ALA 195 221 221 ALA ALA A . n 
A 1 196 ASP 196 222 222 ASP ASP A . n 
A 1 197 TRP 197 223 223 TRP TRP A . n 
A 1 198 VAL 198 224 224 VAL VAL A . n 
A 1 199 GLU 199 225 225 GLU GLU A . n 
A 1 200 GLY 200 226 226 GLY GLY A . n 
A 1 201 TYR 201 227 227 TYR TYR A . n 
A 1 202 SER 202 228 228 SER SER A . n 
A 1 203 MET 203 229 229 MET MET A . n 
A 1 204 GLU 204 230 230 GLU GLU A . n 
A 1 205 TYR 205 231 231 TYR TYR A . n 
A 1 206 LEU 206 232 232 LEU LEU A . n 
A 1 207 SER 207 233 233 SER SER A . n 
A 1 208 ARG 208 234 234 ARG ARG A . n 
A 1 209 HIS 209 235 235 HIS HIS A . n 
A 1 210 TRP 210 236 236 TRP TRP A . n 
A 1 211 LEU 211 237 237 LEU LEU A . n 
A 1 212 PHE 212 238 238 PHE PHE A . n 
A 1 213 SER 213 239 239 SER SER A . n 
A 1 214 PRO 214 240 240 PRO PRO A . n 
A 1 215 PHE 215 241 241 PHE PHE A . n 
A 1 216 LYS 216 242 242 LYS LYS A . n 
A 1 217 LEU 217 243 243 LEU LEU A . n 
A 1 218 LEU 218 244 244 LEU LEU A . n 
A 1 219 LEU 219 245 245 LEU LEU A . n 
A 1 220 SER 220 246 246 SER SER A . n 
A 1 221 GLU 221 247 247 GLU GLU A . n 
A 1 222 GLU 222 248 248 GLU GLU A . n 
A 1 223 LEU 223 249 249 LEU LEU A . n 
A 1 224 THR 224 250 250 THR THR A . n 
A 1 225 SER 225 251 251 SER SER A . n 
A 1 226 LEU 226 252 252 LEU LEU A . n 
A 1 227 LEU 227 253 253 LEU LEU A . n 
A 1 228 VAL 228 254 254 VAL VAL A . n 
A 1 229 VAL 229 255 255 VAL VAL A . n 
A 1 230 HIS 230 256 256 HIS HIS A . n 
A 1 231 TRP 231 257 257 TRP TRP A . n 
A 1 232 GLY 232 258 258 GLY GLY A . n 
A 1 233 GLY 233 259 259 GLY GLY A . n 
A 1 234 LEU 234 260 260 LEU LEU A . n 
A 1 235 LEU 235 261 261 LEU LEU A . n 
A 1 236 LEU 236 262 262 LEU LEU A . n 
A 1 237 ASP 237 263 263 ASP ASP A . n 
A 1 238 LEU 238 264 264 LEU LEU A . n 
A 1 239 SER 239 265 265 SER SER A . n 
A 1 240 ALA 240 266 266 ALA ALA A . n 
A 1 241 GLY 241 267 267 GLY GLY A . n 
A 1 242 PHE 242 268 268 PHE PHE A . n 
A 1 243 LEU 243 269 269 LEU LEU A . n 
A 1 244 LEU 244 270 270 LEU LEU A . n 
A 1 245 PHE 245 271 271 PHE PHE A . n 
A 1 246 PHE 246 272 272 PHE PHE A . n 
A 1 247 ASP 247 273 273 ASP ASP A . n 
A 1 248 VAL 248 274 274 VAL VAL A . n 
A 1 249 SER 249 275 275 SER SER A . n 
A 1 250 ARG 250 276 276 ARG ARG A . n 
A 1 251 SER 251 277 277 SER SER A . n 
A 1 252 ILE 252 278 278 ILE ILE A . n 
A 1 253 GLY 253 279 279 GLY GLY A . n 
A 1 254 LEU 254 280 280 LEU LEU A . n 
A 1 255 PHE 255 281 281 PHE PHE A . n 
A 1 256 PHE 256 282 282 PHE PHE A . n 
A 1 257 VAL 257 283 283 VAL VAL A . n 
A 1 258 SER 258 284 284 SER SER A . n 
A 1 259 TYR 259 285 285 TYR TYR A . n 
A 1 260 PHE 260 286 286 PHE PHE A . n 
A 1 261 HIS 261 287 287 HIS HIS A . n 
A 1 262 CYS 262 288 288 CYS CYS A . n 
A 1 263 MET 263 289 289 MET MET A . n 
A 1 264 ASN 264 290 290 ASN ASN A . n 
A 1 265 SER 265 291 291 SER SER A . n 
A 1 266 GLN 266 292 292 GLN GLN A . n 
A 1 267 LEU 267 293 293 LEU LEU A . n 
A 1 268 PHE 268 294 294 PHE PHE A . n 
A 1 269 SER 269 295 295 SER SER A . n 
A 1 270 ILE 270 296 296 ILE ILE A . n 
A 1 271 GLY 271 297 297 GLY GLY A . n 
A 1 272 MET 272 298 298 MET MET A . n 
A 1 273 PHE 273 299 299 PHE PHE A . n 
A 1 274 SER 274 300 300 SER SER A . n 
A 1 275 TYR 275 301 301 TYR TYR A . n 
A 1 276 VAL 276 302 302 VAL VAL A . n 
A 1 277 MET 277 303 303 MET MET A . n 
A 1 278 LEU 278 304 304 LEU LEU A . n 
A 1 279 ALA 279 305 305 ALA ALA A . n 
A 1 280 SER 280 306 306 SER SER A . n 
A 1 281 SER 281 307 307 SER SER A . n 
A 1 282 PRO 282 308 308 PRO PRO A . n 
A 1 283 LEU 283 309 309 LEU LEU A . n 
A 1 284 PHE 284 310 310 PHE PHE A . n 
A 1 285 CYS 285 311 311 CYS CYS A . n 
A 1 286 SER 286 312 312 SER SER A . n 
A 1 287 PRO 287 313 313 PRO PRO A . n 
A 1 288 GLU 288 314 314 GLU GLU A . n 
A 1 289 TRP 289 315 315 TRP TRP A . n 
A 1 290 PRO 290 316 316 PRO PRO A . n 
A 1 291 ARG 291 317 317 ARG ARG A . n 
A 1 292 LYS 292 318 318 LYS LYS A . n 
A 1 293 LEU 293 319 319 LEU LEU A . n 
A 1 294 VAL 294 320 320 VAL VAL A . n 
A 1 295 SER 295 321 321 SER SER A . n 
A 1 296 TYR 296 322 ?   ?   ?   A . n 
A 1 297 CYS 297 323 ?   ?   ?   A . n 
A 1 298 PRO 298 324 ?   ?   ?   A . n 
A 1 299 ARG 299 325 ?   ?   ?   A . n 
A 1 300 ARG 300 326 ?   ?   ?   A . n 
A 1 301 LEU 301 327 ?   ?   ?   A . n 
A 1 302 GLN 302 328 ?   ?   ?   A . n 
A 1 303 GLN 303 329 ?   ?   ?   A . n 
A 1 304 LEU 304 330 ?   ?   ?   A . n 
A 1 305 LEU 305 331 ?   ?   ?   A . n 
A 1 306 PRO 306 332 ?   ?   ?   A . n 
A 1 307 LEU 307 333 ?   ?   ?   A . n 
A 1 308 LYS 308 334 ?   ?   ?   A . n 
A 1 309 ALA 309 335 ?   ?   ?   A . n 
A 1 310 ALA 310 336 ?   ?   ?   A . n 
A 1 311 PRO 311 337 ?   ?   ?   A . n 
A 1 312 GLN 312 338 ?   ?   ?   A . n 
A 1 313 PRO 313 339 ?   ?   ?   A . n 
A 1 314 SER 314 340 ?   ?   ?   A . n 
A 1 315 VAL 315 341 ?   ?   ?   A . n 
A 1 316 SER 316 342 ?   ?   ?   A . n 
A 1 317 CYS 317 343 ?   ?   ?   A . n 
A 1 318 VAL 318 344 ?   ?   ?   A . n 
A 1 319 TYR 319 345 ?   ?   ?   A . n 
A 1 320 LYS 320 346 ?   ?   ?   A . n 
A 1 321 ARG 321 347 ?   ?   ?   A . n 
A 1 322 SER 322 348 ?   ?   ?   A . n 
A 1 323 ARG 323 349 ?   ?   ?   A . n 
A 1 324 GLY 324 350 ?   ?   ?   A . n 
A 1 325 LYS 325 351 ?   ?   ?   A . n 
A 1 326 SER 326 352 ?   ?   ?   A . n 
A 1 327 GLY 327 353 ?   ?   ?   A . n 
A 1 328 GLN 328 354 ?   ?   ?   A . n 
A 1 329 LYS 329 355 355 LYS LYS A . n 
A 1 330 PRO 330 356 356 PRO PRO A . n 
A 1 331 GLY 331 357 357 GLY GLY A . n 
A 1 332 LEU 332 358 358 LEU LEU A . n 
A 1 333 ARG 333 359 359 ARG ARG A . n 
A 1 334 HIS 334 360 360 HIS HIS A . n 
A 1 335 GLN 335 361 361 GLN GLN A . n 
A 1 336 LEU 336 362 362 LEU LEU A . n 
A 1 337 GLY 337 363 363 GLY GLY A . n 
A 1 338 ALA 338 364 364 ALA ALA A . n 
A 1 339 ALA 339 365 365 ALA ALA A . n 
A 1 340 PHE 340 366 366 PHE PHE A . n 
A 1 341 THR 341 367 367 THR THR A . n 
A 1 342 LEU 342 368 368 LEU LEU A . n 
A 1 343 LEU 343 369 369 LEU LEU A . n 
A 1 344 TYR 344 370 370 TYR TYR A . n 
A 1 345 LEU 345 371 371 LEU LEU A . n 
A 1 346 LEU 346 372 372 LEU LEU A . n 
A 1 347 GLU 347 373 373 GLU GLU A . n 
A 1 348 GLN 348 374 374 GLN GLN A . n 
A 1 349 LEU 349 375 375 LEU LEU A . n 
A 1 350 PHE 350 376 376 PHE PHE A . n 
A 1 351 LEU 351 377 377 LEU LEU A . n 
A 1 352 PRO 352 378 378 PRO PRO A . n 
A 1 353 TYR 353 379 379 TYR TYR A . n 
A 1 354 SER 354 380 380 SER SER A . n 
A 1 355 HIS 355 381 381 HIS HIS A . n 
A 1 356 PHE 356 382 382 PHE PHE A . n 
A 1 357 LEU 357 383 383 LEU LEU A . n 
A 1 358 THR 358 384 384 THR THR A . n 
A 1 359 GLN 359 385 385 GLN GLN A . n 
A 1 360 GLY 360 386 386 GLY GLY A . n 
A 1 361 TYR 361 387 387 TYR TYR A . n 
A 1 362 ASN 362 388 388 ASN ASN A . n 
A 1 363 ASN 363 389 389 ASN ASN A . n 
A 1 364 TRP 364 390 390 TRP TRP A . n 
A 1 365 THR 365 391 391 THR THR A . n 
A 1 366 ASN 366 392 392 ASN ASN A . n 
A 1 367 GLY 367 393 393 GLY GLY A . n 
A 1 368 LEU 368 394 394 LEU LEU A . n 
A 1 369 TYR 369 395 395 TYR TYR A . n 
A 1 370 GLY 370 396 396 GLY GLY A . n 
A 1 371 TYR 371 397 397 TYR TYR A . n 
A 1 372 SER 372 398 398 SER SER A . n 
A 1 373 TRP 373 399 399 TRP TRP A . n 
A 1 374 ASP 374 400 400 ASP ASP A . n 
A 1 375 MET 375 401 401 MET MET A . n 
A 1 376 MET 376 402 402 MET MET A . n 
A 1 377 VAL 377 403 403 VAL VAL A . n 
A 1 378 HIS 378 404 404 HIS HIS A . n 
A 1 379 SER 379 405 405 SER SER A . n 
A 1 380 ARG 380 406 406 ARG ARG A . n 
A 1 381 SER 381 407 407 SER SER A . n 
A 1 382 HIS 382 408 408 HIS HIS A . n 
A 1 383 GLN 383 409 409 GLN GLN A . n 
A 1 384 HIS 384 410 410 HIS HIS A . n 
A 1 385 VAL 385 411 411 VAL VAL A . n 
A 1 386 LYS 386 412 412 LYS LYS A . n 
A 1 387 ILE 387 413 413 ILE ILE A . n 
A 1 388 THR 388 414 414 THR THR A . n 
A 1 389 TYR 389 415 415 TYR TYR A . n 
A 1 390 ARG 390 416 416 ARG ARG A . n 
A 1 391 ASP 391 417 417 ASP ASP A . n 
A 1 392 GLY 392 418 418 GLY GLY A . n 
A 1 393 ARG 393 419 419 ARG ARG A . n 
A 1 394 THR 394 420 420 THR THR A . n 
A 1 395 GLY 395 421 421 GLY GLY A . n 
A 1 396 GLU 396 422 422 GLU GLU A . n 
A 1 397 LEU 397 423 423 LEU LEU A . n 
A 1 398 GLY 398 424 424 GLY GLY A . n 
A 1 399 TYR 399 425 425 TYR TYR A . n 
A 1 400 LEU 400 426 426 LEU LEU A . n 
A 1 401 ASN 401 427 427 ASN ASN A . n 
A 1 402 PRO 402 428 428 PRO PRO A . n 
A 1 403 GLY 403 429 429 GLY GLY A . n 
A 1 404 VAL 404 430 430 VAL VAL A . n 
A 1 405 PHE 405 431 431 PHE PHE A . n 
A 1 406 THR 406 432 432 THR THR A . n 
A 1 407 GLN 407 433 433 GLN GLN A . n 
A 1 408 SER 408 434 434 SER SER A . n 
A 1 409 ARG 409 435 435 ARG ARG A . n 
A 1 410 ARG 410 436 436 ARG ARG A . n 
A 1 411 TRP 411 437 437 TRP TRP A . n 
A 1 412 LYS 412 438 438 LYS LYS A . n 
A 1 413 ASP 413 439 439 ASP ASP A . n 
A 1 414 HIS 414 440 440 HIS HIS A . n 
A 1 415 ALA 415 441 441 ALA ALA A . n 
A 1 416 ASP 416 442 442 ASP ASP A . n 
A 1 417 MET 417 443 443 MET MET A . n 
A 1 418 LEU 418 444 444 LEU LEU A . n 
A 1 419 LYS 419 445 445 LYS LYS A . n 
A 1 420 GLN 420 446 446 GLN GLN A . n 
A 1 421 TYR 421 447 447 TYR TYR A . n 
A 1 422 ALA 422 448 448 ALA ALA A . n 
A 1 423 THR 423 449 449 THR THR A . n 
A 1 424 CYS 424 450 450 CYS CYS A . n 
A 1 425 LEU 425 451 451 LEU LEU A . n 
A 1 426 SER 426 452 452 SER SER A . n 
A 1 427 ARG 427 453 453 ARG ARG A . n 
A 1 428 LEU 428 454 454 LEU LEU A . n 
A 1 429 LEU 429 455 455 LEU LEU A . n 
A 1 430 PRO 430 456 456 PRO PRO A . n 
A 1 431 LYS 431 457 457 LYS LYS A . n 
A 1 432 TYR 432 458 458 TYR TYR A . n 
A 1 433 ASN 433 459 459 ASN ASN A . n 
A 1 434 VAL 434 460 460 VAL VAL A . n 
A 1 435 THR 435 461 461 THR THR A . n 
A 1 436 GLU 436 462 462 GLU GLU A . n 
A 1 437 PRO 437 463 463 PRO PRO A . n 
A 1 438 GLN 438 464 464 GLN GLN A . n 
A 1 439 ILE 439 465 465 ILE ILE A . n 
A 1 440 TYR 440 466 466 TYR TYR A . n 
A 1 441 PHE 441 467 467 PHE PHE A . n 
A 1 442 ASP 442 468 468 ASP ASP A . n 
A 1 443 ILE 443 469 469 ILE ILE A . n 
A 1 444 TRP 444 470 470 TRP TRP A . n 
A 1 445 VAL 445 471 471 VAL VAL A . n 
A 1 446 SER 446 472 472 SER SER A . n 
A 1 447 ILE 447 473 473 ILE ILE A . n 
A 1 448 ASN 448 474 474 ASN ASN A . n 
A 1 449 ASP 449 475 475 ASP ASP A . n 
A 1 450 ARG 450 476 476 ARG ARG A . n 
A 1 451 PHE 451 477 477 PHE PHE A . n 
A 1 452 GLN 452 478 478 GLN GLN A . n 
A 1 453 GLN 453 479 479 GLN GLN A . n 
A 1 454 ARG 454 480 480 ARG ARG A . n 
A 1 455 ILE 455 481 481 ILE ILE A . n 
A 1 456 PHE 456 482 482 PHE PHE A . n 
A 1 457 ASP 457 483 483 ASP ASP A . n 
A 1 458 PRO 458 484 484 PRO PRO A . n 
A 1 459 ARG 459 485 485 ARG ARG A . n 
A 1 460 VAL 460 486 486 VAL VAL A . n 
A 1 461 ASP 461 487 487 ASP ASP A . n 
A 1 462 ILE 462 488 488 ILE ILE A . n 
A 1 463 VAL 463 489 489 VAL VAL A . n 
A 1 464 GLN 464 490 490 GLN GLN A . n 
A 1 465 ALA 465 491 491 ALA ALA A . n 
A 1 466 ALA 466 492 492 ALA ALA A . n 
A 1 467 TRP 467 493 493 TRP TRP A . n 
A 1 468 SER 468 494 494 SER SER A . n 
A 1 469 PRO 469 495 495 PRO PRO A . n 
A 1 470 PHE 470 496 496 PHE PHE A . n 
A 1 471 GLN 471 497 497 GLN GLN A . n 
A 1 472 ARG 472 498 498 ARG ARG A . n 
A 1 473 THR 473 499 499 THR THR A . n 
A 1 474 SER 474 500 500 SER SER A . n 
A 1 475 TRP 475 501 501 TRP TRP A . n 
A 1 476 VAL 476 502 502 VAL VAL A . n 
A 1 477 GLN 477 503 503 GLN GLN A . n 
A 1 478 PRO 478 504 504 PRO PRO A . n 
A 1 479 LEU 479 505 505 LEU LEU A . n 
A 1 480 LEU 480 506 506 LEU LEU A . n 
A 1 481 MET 481 507 507 MET MET A . n 
A 1 482 ASP 482 508 508 ASP ASP A . n 
A 1 483 LEU 483 509 509 LEU LEU A . n 
A 1 484 SER 484 510 510 SER SER A . n 
A 1 485 PRO 485 511 511 PRO PRO A . n 
A 1 486 TRP 486 512 512 TRP TRP A . n 
A 1 487 ARG 487 513 513 ARG ARG A . n 
A 1 488 ALA 488 514 514 ALA ALA A . n 
A 1 489 LYS 489 515 515 LYS LYS A . n 
A 1 490 LEU 490 516 516 LEU LEU A . n 
A 1 491 GLN 491 517 517 GLN GLN A . n 
A 1 492 GLU 492 518 518 GLU GLU A . n 
A 1 493 ILE 493 519 519 ILE ILE A . n 
A 1 494 LYS 494 520 520 LYS LYS A . n 
A 1 495 SER 495 521 521 SER SER A . n 
A 1 496 SER 496 522 522 SER SER A . n 
A 1 497 LEU 497 523 523 LEU LEU A . n 
A 1 498 ASP 498 524 524 ASP ASP A . n 
A 1 499 ASN 499 525 525 ASN ASN A . n 
A 1 500 HIS 500 526 526 HIS HIS A . n 
A 1 501 THR 501 527 527 THR THR A . n 
A 1 502 GLU 502 528 528 GLU GLU A . n 
A 1 503 VAL 503 529 529 VAL VAL A . n 
A 1 504 VAL 504 530 530 VAL VAL A . n 
A 1 505 PHE 505 531 531 PHE PHE A . n 
A 1 506 ILE 506 532 532 ILE ILE A . n 
A 1 507 ALA 507 533 533 ALA ALA A . n 
A 1 508 ASP 508 534 534 ASP ASP A . n 
A 1 509 PHE 509 535 535 PHE PHE A . n 
A 1 510 PRO 510 536 536 PRO PRO A . n 
A 1 511 GLY 511 537 537 GLY GLY A . n 
A 1 512 LEU 512 538 538 LEU LEU A . n 
A 1 513 HIS 513 539 539 HIS HIS A . n 
A 1 514 LEU 514 540 540 LEU LEU A . n 
A 1 515 GLU 515 541 541 GLU GLU A . n 
A 1 516 ASN 516 542 542 ASN ASN A . n 
A 1 517 PHE 517 543 543 PHE PHE A . n 
A 1 518 VAL 518 544 544 VAL VAL A . n 
A 1 519 SER 519 545 545 SER SER A . n 
A 1 520 GLU 520 546 546 GLU GLU A . n 
A 1 521 ASP 521 547 547 ASP ASP A . n 
A 1 522 LEU 522 548 548 LEU LEU A . n 
A 1 523 GLY 523 549 549 GLY GLY A . n 
A 1 524 ASN 524 550 550 ASN ASN A . n 
A 1 525 THR 525 551 551 THR THR A . n 
A 1 526 SER 526 552 552 SER SER A . n 
A 1 527 ILE 527 553 553 ILE ILE A . n 
A 1 528 GLN 528 554 554 GLN GLN A . n 
A 1 529 LEU 529 555 555 LEU LEU A . n 
A 1 530 LEU 530 556 556 LEU LEU A . n 
A 1 531 GLN 531 557 557 GLN GLN A . n 
A 1 532 GLY 532 558 558 GLY GLY A . n 
A 1 533 GLU 533 559 559 GLU GLU A . n 
A 1 534 VAL 534 560 560 VAL VAL A . n 
A 1 535 THR 535 561 561 THR THR A . n 
A 1 536 VAL 536 562 562 VAL VAL A . n 
A 1 537 GLU 537 563 563 GLU GLU A . n 
A 1 538 LEU 538 564 564 LEU LEU A . n 
A 1 539 VAL 539 565 565 VAL VAL A . n 
A 1 540 ALA 540 566 566 ALA ALA A . n 
A 1 541 GLU 541 567 567 GLU GLU A . n 
A 1 542 GLN 542 568 568 GLN GLN A . n 
A 1 543 LYS 543 569 569 LYS LYS A . n 
A 1 544 ASN 544 570 570 ASN ASN A . n 
A 1 545 GLN 545 571 571 GLN GLN A . n 
A 1 546 THR 546 572 572 THR THR A . n 
A 1 547 LEU 547 573 573 LEU LEU A . n 
A 1 548 ARG 548 574 574 ARG ARG A . n 
A 1 549 GLU 549 575 575 GLU GLU A . n 
A 1 550 GLY 550 576 576 GLY GLY A . n 
A 1 551 GLU 551 577 577 GLU GLU A . n 
A 1 552 LYS 552 578 578 LYS LYS A . n 
A 1 553 MET 553 579 579 MET MET A . n 
A 1 554 GLN 554 580 580 GLN GLN A . n 
A 1 555 LEU 555 581 581 LEU LEU A . n 
A 1 556 PRO 556 582 582 PRO PRO A . n 
A 1 557 ALA 557 583 583 ALA ALA A . n 
A 1 558 GLY 558 584 584 GLY GLY A . n 
A 1 559 GLU 559 585 585 GLU GLU A . n 
A 1 560 TYR 560 586 586 TYR TYR A . n 
A 1 561 HIS 561 587 587 HIS HIS A . n 
A 1 562 LYS 562 588 588 LYS LYS A . n 
A 1 563 VAL 563 589 589 VAL VAL A . n 
A 1 564 TYR 564 590 590 TYR TYR A . n 
A 1 565 THR 565 591 591 THR THR A . n 
A 1 566 THR 566 592 592 THR THR A . n 
A 1 567 SER 567 593 593 SER SER A . n 
A 1 568 PRO 568 594 594 PRO PRO A . n 
A 1 569 SER 569 595 595 SER SER A . n 
A 1 570 PRO 570 596 596 PRO PRO A . n 
A 1 571 SER 571 597 597 SER SER A . n 
A 1 572 CYS 572 598 598 CYS CYS A . n 
A 1 573 TYR 573 599 599 TYR TYR A . n 
A 1 574 MET 574 600 600 MET MET A . n 
A 1 575 TYR 575 601 601 TYR TYR A . n 
A 1 576 VAL 576 602 602 VAL VAL A . n 
A 1 577 TYR 577 603 603 TYR TYR A . n 
A 1 578 VAL 578 604 604 VAL VAL A . n 
A 1 579 ASN 579 605 605 ASN ASN A . n 
A 1 580 THR 580 606 606 THR THR A . n 
A 1 581 THR 581 607 607 THR THR A . n 
A 1 582 GLU 582 608 608 GLU GLU A . n 
A 1 583 LEU 583 609 609 LEU LEU A . n 
A 1 584 ALA 584 610 610 ALA ALA A . n 
A 1 585 LEU 585 611 611 LEU LEU A . n 
A 1 586 GLU 586 612 612 GLU GLU A . n 
A 1 587 GLN 587 613 613 GLN GLN A . n 
A 1 588 ASP 588 614 614 ASP ASP A . n 
A 1 589 LEU 589 615 615 LEU LEU A . n 
A 1 590 ALA 590 616 616 ALA ALA A . n 
A 1 591 TYR 591 617 617 TYR TYR A . n 
A 1 592 LEU 592 618 618 LEU LEU A . n 
A 1 593 GLN 593 619 619 GLN GLN A . n 
A 1 594 GLU 594 620 620 GLU GLU A . n 
A 1 595 LEU 595 621 621 LEU LEU A . n 
A 1 596 LYS 596 622 622 LYS LYS A . n 
A 1 597 GLU 597 623 623 GLU GLU A . n 
A 1 598 LYS 598 624 624 LYS LYS A . n 
A 1 599 VAL 599 625 625 VAL VAL A . n 
A 1 600 GLU 600 626 626 GLU GLU A . n 
A 1 601 ASN 601 627 627 ASN ASN A . n 
A 1 602 GLY 602 628 628 GLY GLY A . n 
A 1 603 SER 603 629 629 SER SER A . n 
A 1 604 GLU 604 630 630 GLU GLU A . n 
A 1 605 THR 605 631 631 THR THR A . n 
A 1 606 GLY 606 632 632 GLY GLY A . n 
A 1 607 PRO 607 633 633 PRO PRO A . n 
A 1 608 LEU 608 634 634 LEU LEU A . n 
A 1 609 PRO 609 635 635 PRO PRO A . n 
A 1 610 PRO 610 636 636 PRO PRO A . n 
A 1 611 GLU 611 637 637 GLU GLU A . n 
A 1 612 LEU 612 638 638 LEU LEU A . n 
A 1 613 GLN 613 639 639 GLN GLN A . n 
A 1 614 PRO 614 640 640 PRO PRO A . n 
A 1 615 LEU 615 641 641 LEU LEU A . n 
A 1 616 LEU 616 642 642 LEU LEU A . n 
A 1 617 GLU 617 643 643 GLU GLU A . n 
A 1 618 GLY 618 644 644 GLY GLY A . n 
A 1 619 GLU 619 645 645 GLU GLU A . n 
A 1 620 VAL 620 646 646 VAL VAL A . n 
A 1 621 LYS 621 647 647 LYS LYS A . n 
A 1 622 GLY 622 648 648 GLY GLY A . n 
A 1 623 GLY 623 649 649 GLY GLY A . n 
A 1 624 PRO 624 650 650 PRO PRO A . n 
A 1 625 GLU 625 651 651 GLU GLU A . n 
A 1 626 PRO 626 652 652 PRO PRO A . n 
A 1 627 THR 627 653 653 THR THR A . n 
A 1 628 PRO 628 654 654 PRO PRO A . n 
A 1 629 LEU 629 655 655 LEU LEU A . n 
A 1 630 VAL 630 656 656 VAL VAL A . n 
A 1 631 GLN 631 657 657 GLN GLN A . n 
A 1 632 THR 632 658 658 THR THR A . n 
A 1 633 PHE 633 659 659 PHE PHE A . n 
A 1 634 LEU 634 660 660 LEU LEU A . n 
A 1 635 ARG 635 661 661 ARG ARG A . n 
A 1 636 ARG 636 662 662 ARG ARG A . n 
A 1 637 GLN 637 663 663 GLN GLN A . n 
A 1 638 GLN 638 664 664 GLN GLN A . n 
A 1 639 ARG 639 665 665 ARG ARG A . n 
A 1 640 LEU 640 666 666 LEU LEU A . n 
A 1 641 GLN 641 667 667 GLN GLN A . n 
A 1 642 GLU 642 668 668 GLU GLU A . n 
A 1 643 ILE 643 669 669 ILE ILE A . n 
A 1 644 GLU 644 670 670 GLU GLU A . n 
A 1 645 ARG 645 671 671 ARG ARG A . n 
A 1 646 ARG 646 672 672 ARG ARG A . n 
A 1 647 ARG 647 673 673 ARG ARG A . n 
A 1 648 ASN 648 674 674 ASN ASN A . n 
A 1 649 THR 649 675 675 THR THR A . n 
A 1 650 PRO 650 676 676 PRO PRO A . n 
A 1 651 PHE 651 677 677 PHE PHE A . n 
A 1 652 HIS 652 678 678 HIS HIS A . n 
A 1 653 GLU 653 679 679 GLU GLU A . n 
A 1 654 ARG 654 680 680 ARG ARG A . n 
A 1 655 PHE 655 681 681 PHE PHE A . n 
A 1 656 PHE 656 682 682 PHE PHE A . n 
A 1 657 ARG 657 683 683 ARG ARG A . n 
A 1 658 PHE 658 684 684 PHE PHE A . n 
A 1 659 LEU 659 685 685 LEU LEU A . n 
A 1 660 LEU 660 686 686 LEU LEU A . n 
A 1 661 ARG 661 687 687 ARG ARG A . n 
A 1 662 LYS 662 688 688 LYS LYS A . n 
A 1 663 LEU 663 689 689 LEU LEU A . n 
A 1 664 TYR 664 690 690 TYR TYR A . n 
A 1 665 VAL 665 691 691 VAL VAL A . n 
A 1 666 PHE 666 692 692 PHE PHE A . n 
A 1 667 ARG 667 693 693 ARG ARG A . n 
A 1 668 ARG 668 694 694 ARG ARG A . n 
A 1 669 SER 669 695 695 SER SER A . n 
A 1 670 PHE 670 696 696 PHE PHE A . n 
A 1 671 LEU 671 697 697 LEU LEU A . n 
A 1 672 MET 672 698 698 MET MET A . n 
A 1 673 THR 673 699 699 THR THR A . n 
A 1 674 CYS 674 700 700 CYS CYS A . n 
A 1 675 ILE 675 701 701 ILE ILE A . n 
A 1 676 SER 676 702 702 SER SER A . n 
A 1 677 LEU 677 703 703 LEU LEU A . n 
A 1 678 ARG 678 704 704 ARG ARG A . n 
A 1 679 ASN 679 705 705 ASN ASN A . n 
A 1 680 LEU 680 706 706 LEU LEU A . n 
A 1 681 ILE 681 707 707 ILE ILE A . n 
A 1 682 LEU 682 708 708 LEU LEU A . n 
A 1 683 GLY 683 709 709 GLY GLY A . n 
A 1 684 ARG 684 710 710 ARG ARG A . n 
A 1 685 PRO 685 711 711 PRO PRO A . n 
A 1 686 SER 686 712 712 SER SER A . n 
A 1 687 LEU 687 713 713 LEU LEU A . n 
A 1 688 GLU 688 714 714 GLU GLU A . n 
A 1 689 GLN 689 715 715 GLN GLN A . n 
A 1 690 LEU 690 716 716 LEU LEU A . n 
A 1 691 ALA 691 717 717 ALA ALA A . n 
A 1 692 GLN 692 718 718 GLN GLN A . n 
A 1 693 GLU 693 719 719 GLU GLU A . n 
A 1 694 VAL 694 720 720 VAL VAL A . n 
A 1 695 THR 695 721 721 THR THR A . n 
A 1 696 TYR 696 722 722 TYR TYR A . n 
A 1 697 ALA 697 723 723 ALA ALA A . n 
A 1 698 ASN 698 724 724 ASN ASN A . n 
A 1 699 LEU 699 725 725 LEU LEU A . n 
A 1 700 ARG 700 726 726 ARG ARG A . n 
A 1 701 PRO 701 727 727 PRO PRO A . n 
A 1 702 PHE 702 728 728 PHE PHE A . n 
A 1 703 GLU 703 729 ?   ?   ?   A . n 
A 1 704 ALA 704 730 ?   ?   ?   A . n 
A 1 705 VAL 705 731 ?   ?   ?   A . n 
A 1 706 GLY 706 732 ?   ?   ?   A . n 
A 1 707 GLU 707 733 ?   ?   ?   A . n 
A 1 708 LEU 708 734 ?   ?   ?   A . n 
A 1 709 ASN 709 735 ?   ?   ?   A . n 
A 1 710 PRO 710 736 ?   ?   ?   A . n 
A 1 711 SER 711 737 ?   ?   ?   A . n 
A 1 712 ASN 712 738 ?   ?   ?   A . n 
A 1 713 THR 713 739 ?   ?   ?   A . n 
A 1 714 ASP 714 740 ?   ?   ?   A . n 
A 1 715 SER 715 741 ?   ?   ?   A . n 
A 1 716 SER 716 742 ?   ?   ?   A . n 
A 1 717 HIS 717 743 ?   ?   ?   A . n 
A 1 718 SER 718 744 ?   ?   ?   A . n 
A 1 719 ASN 719 745 ?   ?   ?   A . n 
A 1 720 PRO 720 746 ?   ?   ?   A . n 
A 1 721 PRO 721 747 ?   ?   ?   A . n 
A 1 722 GLU 722 748 ?   ?   ?   A . n 
A 1 723 SER 723 749 ?   ?   ?   A . n 
A 1 724 ASN 724 750 ?   ?   ?   A . n 
A 1 725 PRO 725 751 ?   ?   ?   A . n 
A 1 726 ASP 726 752 ?   ?   ?   A . n 
A 1 727 PRO 727 753 ?   ?   ?   A . n 
A 1 728 VAL 728 754 ?   ?   ?   A . n 
A 1 729 HIS 729 755 ?   ?   ?   A . n 
A 1 730 SER 730 756 ?   ?   ?   A . n 
A 1 731 GLU 731 757 ?   ?   ?   A . n 
A 1 732 PHE 732 758 ?   ?   ?   A . n 
B 2 1   GLU 1   24  ?   ?   ?   P . n 
B 2 2   GLU 2   25  25  GLU GLU P . n 
B 2 3   THR 3   26  26  THR THR P . n 
B 2 4   ASP 4   27  27  ASP ASP P . n 
B 2 5   GLN 5   28  28  GLN GLN P . n 
B 2 6   GLU 6   29  29  GLU GLU P . n 
B 2 7   VAL 7   30  30  VAL VAL P . n 
B 2 8   PHE 8   31  31  PHE PHE P . n 
B 2 9   LEU 9   32  32  LEU LEU P . n 
B 2 10  GLY 10  33  33  GLY GLY P . n 
B 2 11  PRO 11  34  34  PRO PRO P . n 
B 2 12  PRO 12  35  35  PRO PRO P . n 
B 2 13  GLU 13  36  36  GLU GLU P . n 
B 2 14  ALA 14  37  37  ALA ALA P . n 
B 2 15  GLN 15  38  38  GLN GLN P . n 
B 2 16  SER 16  39  39  SER SER P . n 
B 2 17  PHE 17  40  40  PHE PHE P . n 
B 2 18  LEU 18  41  41  LEU LEU P . n 
B 2 19  SER 19  42  42  SER SER P . n 
B 2 20  SER 20  43  43  SER SER P . n 
B 2 21  HIS 21  44  44  HIS HIS P . n 
B 2 22  THR 22  45  45  THR THR P . n 
B 2 23  ARG 23  46  46  ARG ARG P . n 
B 2 24  ILE 24  47  ?   ?   ?   P . n 
B 2 25  PRO 25  48  ?   ?   ?   P . n 
B 2 26  ARG 26  49  ?   ?   ?   P . n 
B 2 27  ALA 27  50  ?   ?   ?   P . n 
B 2 28  ASN 28  51  ?   ?   ?   P . n 
B 2 29  HIS 29  52  ?   ?   ?   P . n 
B 2 30  TRP 30  53  ?   ?   ?   P . n 
B 2 31  ASP 31  54  ?   ?   ?   P . n 
B 2 32  LEU 32  55  ?   ?   ?   P . n 
B 2 33  GLU 33  56  ?   ?   ?   P . n 
B 2 34  LEU 34  57  ?   ?   ?   P . n 
B 2 35  LEU 35  58  ?   ?   ?   P . n 
B 2 36  THR 36  59  ?   ?   ?   P . n 
B 2 37  PRO 37  60  ?   ?   ?   P . n 
B 2 38  GLY 38  61  ?   ?   ?   P . n 
B 2 39  ASN 39  62  ?   ?   ?   P . n 
B 2 40  LEU 40  63  ?   ?   ?   P . n 
B 2 41  GLU 41  64  ?   ?   ?   P . n 
B 2 42  ARG 42  65  ?   ?   ?   P . n 
B 2 43  GLU 43  66  ?   ?   ?   P . n 
B 2 44  CYS 44  67  ?   ?   ?   P . n 
B 2 45  LEU 45  68  ?   ?   ?   P . n 
B 2 46  GLU 46  69  ?   ?   ?   P . n 
B 2 47  GLU 47  70  ?   ?   ?   P . n 
B 2 48  ARG 48  71  ?   ?   ?   P . n 
B 2 49  CYS 49  72  ?   ?   ?   P . n 
B 2 50  SER 50  73  ?   ?   ?   P . n 
B 2 51  TRP 51  74  ?   ?   ?   P . n 
B 2 52  GLU 52  75  ?   ?   ?   P . n 
B 2 53  GLU 53  76  ?   ?   ?   P . n 
B 2 54  ALA 54  77  ?   ?   ?   P . n 
B 2 55  ARG 55  78  ?   ?   ?   P . n 
B 2 56  GLU 56  79  ?   ?   ?   P . n 
B 2 57  TYR 57  80  ?   ?   ?   P . n 
B 2 58  PHE 58  81  ?   ?   ?   P . n 
B 2 59  GLU 59  82  ?   ?   ?   P . n 
B 2 60  ASP 60  83  ?   ?   ?   P . n 
B 2 61  ASN 61  84  ?   ?   ?   P . n 
B 2 62  THR 62  85  ?   ?   ?   P . n 
B 2 63  LEU 63  86  86  LEU LEU P . n 
B 2 64  THR 64  87  87  THR THR P . n 
B 2 65  GLU 65  88  88  GLU GLU P . n 
B 2 66  ARG 66  89  89  ARG ARG P . n 
B 2 67  PHE 67  90  90  PHE PHE P . n 
B 2 68  TRP 68  91  91  TRP TRP P . n 
B 2 69  GLU 69  92  92  GLU GLU P . n 
B 2 70  SER 70  93  93  SER SER P . n 
B 2 71  TYR 71  94  94  TYR TYR P . n 
B 2 72  ILE 72  95  95  ILE ILE P . n 
B 2 73  TYR 73  96  96  TYR TYR P . n 
B 2 74  ASN 74  97  97  ASN ASN P . n 
B 2 75  GLY 75  98  98  GLY GLY P . n 
B 2 76  LYS 76  99  ?   ?   ?   P . n 
B 2 77  GLY 77  100 ?   ?   ?   P . n 
B 2 78  GLY 78  101 ?   ?   ?   P . n 
B 2 79  ARG 79  102 ?   ?   ?   P . n 
B 2 80  GLY 80  103 ?   ?   ?   P . n 
B 2 81  ARG 81  104 ?   ?   ?   P . n 
B 2 82  VAL 82  105 ?   ?   ?   P . n 
B 2 83  ASP 83  106 ?   ?   ?   P . n 
B 2 84  VAL 84  107 ?   ?   ?   P . n 
B 2 85  ALA 85  108 ?   ?   ?   P . n 
B 2 86  SER 86  109 ?   ?   ?   P . n 
B 2 87  LEU 87  110 ?   ?   ?   P . n 
B 2 88  ALA 88  111 ?   ?   ?   P . n 
B 2 89  VAL 89  112 ?   ?   ?   P . n 
B 2 90  GLY 90  113 ?   ?   ?   P . n 
B 2 91  LEU 91  114 ?   ?   ?   P . n 
B 2 92  THR 92  115 ?   ?   ?   P . n 
B 2 93  GLY 93  116 ?   ?   ?   P . n 
B 2 94  GLY 94  117 ?   ?   ?   P . n 
B 2 95  ILE 95  118 ?   ?   ?   P . n 
B 2 96  LEU 96  119 ?   ?   ?   P . n 
B 2 97  LEU 97  120 ?   ?   ?   P . n 
B 2 98  ILE 98  121 ?   ?   ?   P . n 
B 2 99  VAL 99  122 ?   ?   ?   P . n 
B 2 100 LEU 100 123 ?   ?   ?   P . n 
B 2 101 ALA 101 124 ?   ?   ?   P . n 
B 2 102 GLY 102 125 ?   ?   ?   P . n 
B 2 103 LEU 103 126 ?   ?   ?   P . n 
B 2 104 GLY 104 127 ?   ?   ?   P . n 
B 2 105 ALA 105 128 ?   ?   ?   P . n 
B 2 106 PHE 106 129 ?   ?   ?   P . n 
B 2 107 TRP 107 130 ?   ?   ?   P . n 
B 2 108 TYR 108 131 ?   ?   ?   P . n 
B 2 109 LEU 109 132 ?   ?   ?   P . n 
B 2 110 ARG 110 133 ?   ?   ?   P . n 
B 2 111 TRP 111 134 ?   ?   ?   P . n 
B 2 112 ARG 112 135 ?   ?   ?   P . n 
B 2 113 GLN 113 136 ?   ?   ?   P . n 
B 2 114 HIS 114 137 ?   ?   ?   P . n 
B 2 115 ARG 115 138 ?   ?   ?   P . n 
B 2 116 GLY 116 139 ?   ?   ?   P . n 
# 
loop_
_pdbx_branch_scheme.asym_id 
_pdbx_branch_scheme.entity_id 
_pdbx_branch_scheme.mon_id 
_pdbx_branch_scheme.num 
_pdbx_branch_scheme.pdb_asym_id 
_pdbx_branch_scheme.pdb_mon_id 
_pdbx_branch_scheme.pdb_seq_num 
_pdbx_branch_scheme.auth_asym_id 
_pdbx_branch_scheme.auth_mon_id 
_pdbx_branch_scheme.auth_seq_num 
_pdbx_branch_scheme.hetero 
C 3 NAG 1 B NAG 1 B NAG 1 n 
C 3 NAG 2 B NAG 2 B NAG 2 n 
D 3 NAG 1 C NAG 1 C NAG 1 n 
D 3 NAG 2 C NAG 2 C NAG 2 n 
E 3 NAG 1 D NAG 1 D NAG 1 n 
E 3 NAG 2 D NAG 2 D NAG 2 n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        6PL 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   6PL 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
F 4 6PL 1 801 802 6PL 6PL A . 
G 4 6PL 1 802 803 6PL 6PL A . 
H 5 NAG 1 803 13  NAG NAG A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 N 1 A 6PL 801 ? C26 ? F 6PL 1 C26 
2 1 N 1 A 6PL 801 ? C25 ? F 6PL 1 C25 
3 1 N 1 A 6PL 801 ? C24 ? F 6PL 1 C24 
4 1 N 1 A 6PL 801 ? C23 ? F 6PL 1 C23 
5 1 N 1 A 6PL 801 ? C47 ? F 6PL 1 C47 
6 1 N 1 A 6PL 801 ? C48 ? F 6PL 1 C48 
7 1 N 1 A 6PL 802 ? C47 ? G 6PL 1 C47 
8 1 N 1 A 6PL 802 ? C48 ? G 6PL 1 C48 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BVQ 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BVQ 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BVQ 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 9BVQ 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.002  ? 6145 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.430  ? 8330 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 11.658 ? 2271 ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.037  ? 898  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.004  ? 1034 ? f_plane_restr      ? ? 
# 
_struct.entry_id                     9BVQ 
_struct.title                        'Vitamin K-dependent gamma-carboxylase with TMG2 propeptide and glutamate-rich region' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BVQ 
_struct_keywords.text            
;GGCX, VKGC, Vitamin K, VKCFD, Hemophilia B, Warfarin, Carboxylation, Blood Coagulaton, Calcium homeostasis, TMG, MEMBRANE PROTEIN, Gla, LYASE-SUBSTRATE complex
;
_struct_keywords.pdbx_keywords   'MEMBRANE PROTEIN,LYASE/SUBSTRATE' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
E N N 3 ? 
F N N 4 ? 
G N N 4 ? 
H N N 5 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP VKGC_HUMAN P38435 ? 1 
;GPRQDSRIGKLLGFEWTDLSSWRRLVTLLNRPTDPASLAVFRFLFGFLMVLDIPQERGLSSLDRKYLDGLDVCRFPLLDA
LRPLPLDWMYLVYTIMFLGALGMMLGLCYRISCVLFLLPYWYVFLLDKTSWNNHSYLYGLLAFQLTFMDANHYWSVDGLL
NAHRRNAHVPLWNYAVLRGQIFIVYFIAGVKKLDADWVEGYSMEYLSRHWLFSPFKLLLSEELTSLLVVHWGGLLLDLSA
GFLLFFDVSRSIGLFFVSYFHCMNSQLFSIGMFSYVMLASSPLFCSPEWPRKLVSYCPRRLQQLLPLKAAPQPSVSCVYK
RSRGKSGQKPGLRHQLGAAFTLLYLLEQLFLPYSHFLTQGYNNWTNGLYGYSWDMMVHSRSHQHVKITYRDGRTGELGYL
NPGVFTQSRRWKDHADMLKQYATCLSRLLPKYNVTEPQIYFDIWVSINDRFQQRIFDPRVDIVQAAWSPFQRTSWVQPLL
MDLSPWRAKLQEIKSSLDNHTEVVFIADFPGLHLENFVSEDLGNTSIQLLQGEVTVELVAEQKNQTLREGEKMQLPAGEY
HKVYTTSPSPSCYMYVYVNTTELALEQDLAYLQELKEKVENGSETGPLPPELQPLLEGEVKGGPEPTPLVQTFLRRQQRL
QEIERRRNTPFHERFFRFLLRKLYVFRRSFLMTCISLRNLILGRPSLEQLAQEVTYANLRPFEAVGELNPSNTDSSHSNP
PESNPDPVHSEF
;
27 
2 UNP TMG2_HUMAN O14669 ? 2 
;EETDQEVFLGPPEAQSFLSSHTRIPRANHWDLELLTPGNLERECLEERCSWEEAREYFEDNTLTERFWESYIYNGKGGRG
RVDVASLAVGLTGGILLIVLAGLGAFWYLRWRQHRG
;
24 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9BVQ A 1 ? 732 ? P38435 27 ? 758 ? 27 758 
2 2 9BVQ P 1 ? 116 ? O14669 24 ? 139 ? 24 139 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 6   ? GLY A 13  ? SER A 32  GLY A 39  1 ? 8  
HELX_P HELX_P2  AA2 GLU A 15  ? SER A 20  ? GLU A 41  SER A 46  5 ? 6  
HELX_P HELX_P3  AA3 SER A 21  ? LEU A 29  ? SER A 47  LEU A 55  1 ? 9  
HELX_P HELX_P4  AA4 PRO A 35  ? ILE A 53  ? PRO A 61  ILE A 79  1 ? 19 
HELX_P HELX_P5  AA5 SER A 61  ? LYS A 65  ? SER A 87  LYS A 91  5 ? 5  
HELX_P HELX_P6  AA6 PRO A 85  ? GLY A 106 ? PRO A 111 GLY A 132 1 ? 22 
HELX_P HELX_P7  AA7 CYS A 108 ? ASP A 127 ? CYS A 134 ASP A 153 1 ? 20 
HELX_P HELX_P8  AA8 LYS A 128 ? TRP A 131 ? LYS A 154 TRP A 157 5 ? 4  
HELX_P HELX_P9  AA9 ASN A 132 ? MET A 148 ? ASN A 158 MET A 174 1 ? 17 
HELX_P HELX_P10 AB1 SER A 155 ? ASN A 161 ? SER A 181 ASN A 187 1 ? 7  
HELX_P HELX_P11 AB2 LEU A 171 ? LYS A 192 ? LEU A 197 LYS A 218 1 ? 22 
HELX_P HELX_P12 AB3 MET A 203 ? LEU A 218 ? MET A 229 LEU A 244 5 ? 16 
HELX_P HELX_P13 AB4 SER A 220 ? VAL A 228 ? SER A 246 VAL A 254 1 ? 9  
HELX_P HELX_P14 AB5 HIS A 230 ? LEU A 244 ? HIS A 256 LEU A 270 1 ? 15 
HELX_P HELX_P15 AB6 SER A 249 ? PHE A 268 ? SER A 275 PHE A 294 1 ? 20 
HELX_P HELX_P16 AB7 MET A 272 ? SER A 281 ? MET A 298 SER A 307 1 ? 10 
HELX_P HELX_P17 AB8 PRO A 282 ? CYS A 285 ? PRO A 308 CYS A 311 5 ? 4  
HELX_P HELX_P18 AB9 GLU A 288 ? SER A 295 ? GLU A 314 SER A 321 1 ? 8  
HELX_P HELX_P19 AC1 LEU A 332 ? LEU A 351 ? LEU A 358 LEU A 377 1 ? 20 
HELX_P HELX_P20 AC2 PRO A 352 ? SER A 354 ? PRO A 378 SER A 380 5 ? 3  
HELX_P HELX_P21 AC3 THR A 358 ? ASN A 362 ? THR A 384 ASN A 388 5 ? 5  
HELX_P HELX_P22 AC4 HIS A 414 ? LEU A 429 ? HIS A 440 LEU A 455 1 ? 16 
HELX_P HELX_P23 AC5 PRO A 430 ? ASN A 433 ? PRO A 456 ASN A 459 5 ? 4  
HELX_P HELX_P24 AC6 PRO A 485 ? LEU A 497 ? PRO A 511 LEU A 523 1 ? 13 
HELX_P HELX_P25 AC7 ASN A 579 ? ASN A 601 ? ASN A 605 ASN A 627 1 ? 23 
HELX_P HELX_P26 AC8 LEU A 612 ? GLY A 618 ? LEU A 638 GLY A 644 1 ? 7  
HELX_P HELX_P27 AC9 THR A 627 ? ASN A 648 ? THR A 653 ASN A 674 1 ? 22 
HELX_P HELX_P28 AD1 PRO A 650 ? GLY A 683 ? PRO A 676 GLY A 709 1 ? 34 
HELX_P HELX_P29 AD2 SER A 686 ? ASN A 698 ? SER A 712 ASN A 724 1 ? 13 
HELX_P HELX_P30 AD3 GLY B 10  ? GLN B 15  ? GLY P 33  GLN P 38  1 ? 6  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ?    ? A CYS 73  SG  ? ? ? 1_555 A CYS 424 SG ? ? A CYS 99  A CYS 450 1_555 ? ? ? ? ? ? ? 2.031 ? ?               
covale1 covale one  ? A ASN 433 ND2 ? ? ? 1_555 H NAG .   C1 ? ? A ASN 459 A NAG 803 1_555 ? ? ? ? ? ? ? 1.440 ? N-Glycosylation 
covale2 covale one  ? A ASN 524 ND2 ? ? ? 1_555 D NAG .   C1 ? ? A ASN 550 C NAG 1   1_555 ? ? ? ? ? ? ? 1.239 ? N-Glycosylation 
covale3 covale one  ? A ASN 544 ND2 ? ? ? 1_555 C NAG .   C1 ? ? A ASN 570 B NAG 1   1_555 ? ? ? ? ? ? ? 1.542 ? N-Glycosylation 
covale4 covale one  ? A ASN 579 ND2 ? ? ? 1_555 E NAG .   C1 ? ? A ASN 605 D NAG 1   1_555 ? ? ? ? ? ? ? 1.442 ? N-Glycosylation 
covale5 covale both ? C NAG .   O4  ? ? ? 1_555 C NAG .   C1 ? ? B NAG 1   B NAG 2   1_555 ? ? ? ? ? ? ? 1.351 ? ?               
covale6 covale both ? D NAG .   O4  ? ? ? 1_555 D NAG .   C1 ? ? C NAG 1   C NAG 2   1_555 ? ? ? ? ? ? ? 1.360 ? ?               
covale7 covale both ? E NAG .   O4  ? ? ? 1_555 E NAG .   C1 ? ? D NAG 1   D NAG 2   1_555 ? ? ? ? ? ? ? 1.442 ? ?               
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 NAG C .  ? ASN A 544 ? NAG B 1   ? 1_555 ASN A 570 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
2 NAG D .  ? ASN A 524 ? NAG C 1   ? 1_555 ASN A 550 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
3 NAG E .  ? ASN A 579 ? NAG D 1   ? 1_555 ASN A 605 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
4 NAG H .  ? ASN A 433 ? NAG A 803 ? 1_555 ASN A 459 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
5 CYS A 73 ? CYS A 424 ? CYS A 99  ? 1_555 CYS A 450 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 4 ? 
AA3 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLN A 453 ? ARG A 454 ? GLN A 479 ARG A 480 
AA1 2 GLN A 438 ? ILE A 447 ? GLN A 464 ILE A 473 
AA1 3 ARG A 380 ? ARG A 390 ? ARG A 406 ARG A 416 
AA1 4 LEU A 397 ? LEU A 400 ? LEU A 423 LEU A 426 
AA1 5 PHE B 8   ? LEU B 9   ? PHE P 31  LEU P 32  
AA2 1 GLU A 502 ? ASP A 508 ? GLU A 528 ASP A 534 
AA2 2 SER A 571 ? TYR A 577 ? SER A 597 TYR A 603 
AA2 3 THR A 525 ? GLN A 531 ? THR A 551 GLN A 557 
AA2 4 LYS A 552 ? LEU A 555 ? LYS A 578 LEU A 581 
AA3 1 HIS A 513 ? PHE A 517 ? HIS A 539 PHE A 543 
AA3 2 TYR A 560 ? THR A 565 ? TYR A 586 THR A 591 
AA3 3 VAL A 534 ? LEU A 538 ? VAL A 560 LEU A 564 
AA3 4 LYS A 543 ? LEU A 547 ? LYS A 569 LEU A 573 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O GLN A 453 ? O GLN A 479 N VAL A 445 ? N VAL A 471 
AA1 2 3 O TYR A 440 ? O TYR A 466 N THR A 388 ? N THR A 414 
AA1 3 4 N TYR A 389 ? N TYR A 415 O GLY A 398 ? O GLY A 424 
AA1 4 5 N TYR A 399 ? N TYR A 425 O LEU B 9   ? O LEU P 32  
AA2 1 2 N ILE A 506 ? N ILE A 532 O TYR A 573 ? O TYR A 599 
AA2 2 3 O VAL A 576 ? O VAL A 602 N SER A 526 ? N SER A 552 
AA2 3 4 N ILE A 527 ? N ILE A 553 O MET A 553 ? O MET A 579 
AA3 1 2 N ASN A 516 ? N ASN A 542 O HIS A 561 ? O HIS A 587 
AA3 2 3 O TYR A 564 ? O TYR A 590 N THR A 535 ? N THR A 561 
AA3 3 4 N LEU A 538 ? N LEU A 564 O LYS A 543 ? O LYS A 569 
# 
_pdbx_entry_details.entry_id                   9BVQ 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O4  B NAG 1   ? ? O5 B NAG 2   ? ? 1.90 
2 1 ND2 A ASN 605 ? ? O5 D NAG 1   ? ? 1.95 
3 1 ND2 A ASN 459 ? ? O5 A NAG 803 ? ? 2.02 
4 1 O4  D NAG 1   ? ? O5 D NAG 2   ? ? 2.07 
5 1 ND2 A ASN 459 ? ? C2 A NAG 803 ? ? 2.08 
6 1 O4  C NAG 1   ? ? O5 C NAG 2   ? ? 2.14 
7 1 CG  A ASN 550 ? ? C1 C NAG 1   ? ? 2.14 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 PRO A 313 ? ? -69.69  2.43    
2 1 ASN A 389 ? ? -149.99 -159.32 
3 1 THR A 461 ? ? -79.24  -168.23 
4 1 GLU A 462 ? ? -55.59  109.00  
5 1 THR P 26  ? ? 58.64   -171.39 
6 1 TRP P 91  ? ? 61.51   -65.63  
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9BVQ 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         REAL 
_em_3d_fitting.ref_protocol      OTHER 
# 
_em_3d_reconstruction.entry_id                    9BVQ 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.3 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               203230 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.5 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Vitamin K-dependent gamma-carboxylase with TMG2 propeptide and glutamate-rich region' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       '1, 2' 
# 
_em_image_scans.entry_id                9BVQ 
_em_image_scans.id                      1 
_em_image_scans.number_digital_images   ? 
_em_image_scans.details                 ? 
_em_image_scans.scanner_model           ? 
_em_image_scans.sampling_size           ? 
_em_image_scans.od_range                ? 
_em_image_scans.quant_bit_size          ? 
_em_image_scans.citation_id             ? 
_em_image_scans.dimension_height        5760 
_em_image_scans.dimension_width         4092 
_em_image_scans.frames_per_image        ? 
_em_image_scans.image_recording_id      1 
_em_image_scans.used_frames_per_image   ? 
# 
_em_imaging.entry_id                        9BVQ 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           'FEI TITAN KRIOS AUTOGRID HOLDER' 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      2.7 
_em_imaging.nominal_defocus_min             1000 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           130000 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   63 
_em_imaging.recording_temperature_maximum   77 
_em_imaging.alignment_procedure             'COMA FREE' 
_em_imaging.c2_aperture_diameter            50.0 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    COPPER 
_em_sample_support.grid_mesh_size   300 
_em_sample_support.grid_type        'Quantifoil R1.2/1.3' 
_em_sample_support.details          ? 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_vitrification.entry_id              9BVQ 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              95 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   283.15 
_em_vitrification.instrument            'LEICA EM GP' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9BVQ 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A GLY 27  ? A GLY 1   
2   1 Y 1 A PRO 28  ? A PRO 2   
3   1 Y 1 A ARG 29  ? A ARG 3   
4   1 Y 1 A GLN 30  ? A GLN 4   
5   1 Y 1 A TYR 322 ? A TYR 296 
6   1 Y 1 A CYS 323 ? A CYS 297 
7   1 Y 1 A PRO 324 ? A PRO 298 
8   1 Y 1 A ARG 325 ? A ARG 299 
9   1 Y 1 A ARG 326 ? A ARG 300 
10  1 Y 1 A LEU 327 ? A LEU 301 
11  1 Y 1 A GLN 328 ? A GLN 302 
12  1 Y 1 A GLN 329 ? A GLN 303 
13  1 Y 1 A LEU 330 ? A LEU 304 
14  1 Y 1 A LEU 331 ? A LEU 305 
15  1 Y 1 A PRO 332 ? A PRO 306 
16  1 Y 1 A LEU 333 ? A LEU 307 
17  1 Y 1 A LYS 334 ? A LYS 308 
18  1 Y 1 A ALA 335 ? A ALA 309 
19  1 Y 1 A ALA 336 ? A ALA 310 
20  1 Y 1 A PRO 337 ? A PRO 311 
21  1 Y 1 A GLN 338 ? A GLN 312 
22  1 Y 1 A PRO 339 ? A PRO 313 
23  1 Y 1 A SER 340 ? A SER 314 
24  1 Y 1 A VAL 341 ? A VAL 315 
25  1 Y 1 A SER 342 ? A SER 316 
26  1 Y 1 A CYS 343 ? A CYS 317 
27  1 Y 1 A VAL 344 ? A VAL 318 
28  1 Y 1 A TYR 345 ? A TYR 319 
29  1 Y 1 A LYS 346 ? A LYS 320 
30  1 Y 1 A ARG 347 ? A ARG 321 
31  1 Y 1 A SER 348 ? A SER 322 
32  1 Y 1 A ARG 349 ? A ARG 323 
33  1 Y 1 A GLY 350 ? A GLY 324 
34  1 Y 1 A LYS 351 ? A LYS 325 
35  1 Y 1 A SER 352 ? A SER 326 
36  1 Y 1 A GLY 353 ? A GLY 327 
37  1 Y 1 A GLN 354 ? A GLN 328 
38  1 Y 1 A GLU 729 ? A GLU 703 
39  1 Y 1 A ALA 730 ? A ALA 704 
40  1 Y 1 A VAL 731 ? A VAL 705 
41  1 Y 1 A GLY 732 ? A GLY 706 
42  1 Y 1 A GLU 733 ? A GLU 707 
43  1 Y 1 A LEU 734 ? A LEU 708 
44  1 Y 1 A ASN 735 ? A ASN 709 
45  1 Y 1 A PRO 736 ? A PRO 710 
46  1 Y 1 A SER 737 ? A SER 711 
47  1 Y 1 A ASN 738 ? A ASN 712 
48  1 Y 1 A THR 739 ? A THR 713 
49  1 Y 1 A ASP 740 ? A ASP 714 
50  1 Y 1 A SER 741 ? A SER 715 
51  1 Y 1 A SER 742 ? A SER 716 
52  1 Y 1 A HIS 743 ? A HIS 717 
53  1 Y 1 A SER 744 ? A SER 718 
54  1 Y 1 A ASN 745 ? A ASN 719 
55  1 Y 1 A PRO 746 ? A PRO 720 
56  1 Y 1 A PRO 747 ? A PRO 721 
57  1 Y 1 A GLU 748 ? A GLU 722 
58  1 Y 1 A SER 749 ? A SER 723 
59  1 Y 1 A ASN 750 ? A ASN 724 
60  1 Y 1 A PRO 751 ? A PRO 725 
61  1 Y 1 A ASP 752 ? A ASP 726 
62  1 Y 1 A PRO 753 ? A PRO 727 
63  1 Y 1 A VAL 754 ? A VAL 728 
64  1 Y 1 A HIS 755 ? A HIS 729 
65  1 Y 1 A SER 756 ? A SER 730 
66  1 Y 1 A GLU 757 ? A GLU 731 
67  1 Y 1 A PHE 758 ? A PHE 732 
68  1 Y 1 P GLU 24  ? B GLU 1   
69  1 Y 1 P ILE 47  ? B ILE 24  
70  1 Y 1 P PRO 48  ? B PRO 25  
71  1 Y 1 P ARG 49  ? B ARG 26  
72  1 Y 1 P ALA 50  ? B ALA 27  
73  1 Y 1 P ASN 51  ? B ASN 28  
74  1 Y 1 P HIS 52  ? B HIS 29  
75  1 Y 1 P TRP 53  ? B TRP 30  
76  1 Y 1 P ASP 54  ? B ASP 31  
77  1 Y 1 P LEU 55  ? B LEU 32  
78  1 Y 1 P GLU 56  ? B GLU 33  
79  1 Y 1 P LEU 57  ? B LEU 34  
80  1 Y 1 P LEU 58  ? B LEU 35  
81  1 Y 1 P THR 59  ? B THR 36  
82  1 Y 1 P PRO 60  ? B PRO 37  
83  1 Y 1 P GLY 61  ? B GLY 38  
84  1 Y 1 P ASN 62  ? B ASN 39  
85  1 Y 1 P LEU 63  ? B LEU 40  
86  1 Y 1 P GLU 64  ? B GLU 41  
87  1 Y 1 P ARG 65  ? B ARG 42  
88  1 Y 1 P GLU 66  ? B GLU 43  
89  1 Y 1 P CYS 67  ? B CYS 44  
90  1 Y 1 P LEU 68  ? B LEU 45  
91  1 Y 1 P GLU 69  ? B GLU 46  
92  1 Y 1 P GLU 70  ? B GLU 47  
93  1 Y 1 P ARG 71  ? B ARG 48  
94  1 Y 1 P CYS 72  ? B CYS 49  
95  1 Y 1 P SER 73  ? B SER 50  
96  1 Y 1 P TRP 74  ? B TRP 51  
97  1 Y 1 P GLU 75  ? B GLU 52  
98  1 Y 1 P GLU 76  ? B GLU 53  
99  1 Y 1 P ALA 77  ? B ALA 54  
100 1 Y 1 P ARG 78  ? B ARG 55  
101 1 Y 1 P GLU 79  ? B GLU 56  
102 1 Y 1 P TYR 80  ? B TYR 57  
103 1 Y 1 P PHE 81  ? B PHE 58  
104 1 Y 1 P GLU 82  ? B GLU 59  
105 1 Y 1 P ASP 83  ? B ASP 60  
106 1 Y 1 P ASN 84  ? B ASN 61  
107 1 Y 1 P THR 85  ? B THR 62  
108 1 Y 1 P LYS 99  ? B LYS 76  
109 1 Y 1 P GLY 100 ? B GLY 77  
110 1 Y 1 P GLY 101 ? B GLY 78  
111 1 Y 1 P ARG 102 ? B ARG 79  
112 1 Y 1 P GLY 103 ? B GLY 80  
113 1 Y 1 P ARG 104 ? B ARG 81  
114 1 Y 1 P VAL 105 ? B VAL 82  
115 1 Y 1 P ASP 106 ? B ASP 83  
116 1 Y 1 P VAL 107 ? B VAL 84  
117 1 Y 1 P ALA 108 ? B ALA 85  
118 1 Y 1 P SER 109 ? B SER 86  
119 1 Y 1 P LEU 110 ? B LEU 87  
120 1 Y 1 P ALA 111 ? B ALA 88  
121 1 Y 1 P VAL 112 ? B VAL 89  
122 1 Y 1 P GLY 113 ? B GLY 90  
123 1 Y 1 P LEU 114 ? B LEU 91  
124 1 Y 1 P THR 115 ? B THR 92  
125 1 Y 1 P GLY 116 ? B GLY 93  
126 1 Y 1 P GLY 117 ? B GLY 94  
127 1 Y 1 P ILE 118 ? B ILE 95  
128 1 Y 1 P LEU 119 ? B LEU 96  
129 1 Y 1 P LEU 120 ? B LEU 97  
130 1 Y 1 P ILE 121 ? B ILE 98  
131 1 Y 1 P VAL 122 ? B VAL 99  
132 1 Y 1 P LEU 123 ? B LEU 100 
133 1 Y 1 P ALA 124 ? B ALA 101 
134 1 Y 1 P GLY 125 ? B GLY 102 
135 1 Y 1 P LEU 126 ? B LEU 103 
136 1 Y 1 P GLY 127 ? B GLY 104 
137 1 Y 1 P ALA 128 ? B ALA 105 
138 1 Y 1 P PHE 129 ? B PHE 106 
139 1 Y 1 P TRP 130 ? B TRP 107 
140 1 Y 1 P TYR 131 ? B TYR 108 
141 1 Y 1 P LEU 132 ? B LEU 109 
142 1 Y 1 P ARG 133 ? B ARG 110 
143 1 Y 1 P TRP 134 ? B TRP 111 
144 1 Y 1 P ARG 135 ? B ARG 112 
145 1 Y 1 P GLN 136 ? B GLN 113 
146 1 Y 1 P HIS 137 ? B HIS 114 
147 1 Y 1 P ARG 138 ? B ARG 115 
148 1 Y 1 P GLY 139 ? B GLY 116 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
6PL C26  C N N 1   
6PL C25  C N N 2   
6PL C24  C N N 3   
6PL C23  C N N 4   
6PL C22  C N N 5   
6PL C21  C N N 6   
6PL C20  C N N 7   
6PL C19  C N N 8   
6PL C18  C N N 9   
6PL C17  C N N 10  
6PL C16  C N N 11  
6PL C15  C N N 12  
6PL C14  C N N 13  
6PL C13  C N N 14  
6PL C12  C N N 15  
6PL C11  C N N 16  
6PL O11  O N N 17  
6PL O3   O N N 18  
6PL C3   C N N 19  
6PL C2   C N R 20  
6PL C1   C N N 21  
6PL O3P  O N N 22  
6PL P    P N S 23  
6PL O1P  O N N 24  
6PL O2P  O N N 25  
6PL O4P  O N N 26  
6PL C4   C N N 27  
6PL C5   C N N 28  
6PL N    N N N 29  
6PL C7   C N N 30  
6PL C8   C N N 31  
6PL C6   C N N 32  
6PL O2   O N N 33  
6PL C31  C N N 34  
6PL O31  O N N 35  
6PL C32  C N N 36  
6PL C33  C N N 37  
6PL C34  C N N 38  
6PL C35  C N N 39  
6PL C36  C N N 40  
6PL C37  C N N 41  
6PL C38  C N N 42  
6PL C39  C N N 43  
6PL C40  C N N 44  
6PL C41  C N N 45  
6PL C42  C N N 46  
6PL C43  C N N 47  
6PL C44  C N N 48  
6PL C45  C N N 49  
6PL C46  C N N 50  
6PL C47  C N N 51  
6PL C48  C N N 52  
6PL H261 H N N 53  
6PL H262 H N N 54  
6PL H263 H N N 55  
6PL H251 H N N 56  
6PL H252 H N N 57  
6PL H241 H N N 58  
6PL H242 H N N 59  
6PL H231 H N N 60  
6PL H232 H N N 61  
6PL H221 H N N 62  
6PL H222 H N N 63  
6PL H211 H N N 64  
6PL H212 H N N 65  
6PL H201 H N N 66  
6PL H202 H N N 67  
6PL H191 H N N 68  
6PL H192 H N N 69  
6PL H181 H N N 70  
6PL H182 H N N 71  
6PL H171 H N N 72  
6PL H172 H N N 73  
6PL H161 H N N 74  
6PL H162 H N N 75  
6PL H151 H N N 76  
6PL H152 H N N 77  
6PL H141 H N N 78  
6PL H142 H N N 79  
6PL H131 H N N 80  
6PL H132 H N N 81  
6PL H121 H N N 82  
6PL H122 H N N 83  
6PL H31  H N N 84  
6PL H32  H N N 85  
6PL H2   H N N 86  
6PL H11  H N N 87  
6PL H12  H N N 88  
6PL H2P  H N N 89  
6PL H41  H N N 90  
6PL H42  H N N 91  
6PL H51  H N N 92  
6PL H52  H N N 93  
6PL H71  H N N 94  
6PL H72  H N N 95  
6PL H73  H N N 96  
6PL H81  H N N 97  
6PL H82  H N N 98  
6PL H83  H N N 99  
6PL H61  H N N 100 
6PL H62  H N N 101 
6PL H63  H N N 102 
6PL H321 H N N 103 
6PL H322 H N N 104 
6PL H331 H N N 105 
6PL H332 H N N 106 
6PL H341 H N N 107 
6PL H342 H N N 108 
6PL H351 H N N 109 
6PL H352 H N N 110 
6PL H361 H N N 111 
6PL H362 H N N 112 
6PL H371 H N N 113 
6PL H372 H N N 114 
6PL H381 H N N 115 
6PL H382 H N N 116 
6PL H391 H N N 117 
6PL H392 H N N 118 
6PL H401 H N N 119 
6PL H402 H N N 120 
6PL H411 H N N 121 
6PL H412 H N N 122 
6PL H421 H N N 123 
6PL H422 H N N 124 
6PL H431 H N N 125 
6PL H432 H N N 126 
6PL H441 H N N 127 
6PL H442 H N N 128 
6PL H451 H N N 129 
6PL H452 H N N 130 
6PL H461 H N N 131 
6PL H462 H N N 132 
6PL H471 H N N 133 
6PL H472 H N N 134 
6PL H481 H N N 135 
6PL H482 H N N 136 
6PL H483 H N N 137 
ALA N    N N N 138 
ALA CA   C N S 139 
ALA C    C N N 140 
ALA O    O N N 141 
ALA CB   C N N 142 
ALA OXT  O N N 143 
ALA H    H N N 144 
ALA H2   H N N 145 
ALA HA   H N N 146 
ALA HB1  H N N 147 
ALA HB2  H N N 148 
ALA HB3  H N N 149 
ALA HXT  H N N 150 
ARG N    N N N 151 
ARG CA   C N S 152 
ARG C    C N N 153 
ARG O    O N N 154 
ARG CB   C N N 155 
ARG CG   C N N 156 
ARG CD   C N N 157 
ARG NE   N N N 158 
ARG CZ   C N N 159 
ARG NH1  N N N 160 
ARG NH2  N N N 161 
ARG OXT  O N N 162 
ARG H    H N N 163 
ARG H2   H N N 164 
ARG HA   H N N 165 
ARG HB2  H N N 166 
ARG HB3  H N N 167 
ARG HG2  H N N 168 
ARG HG3  H N N 169 
ARG HD2  H N N 170 
ARG HD3  H N N 171 
ARG HE   H N N 172 
ARG HH11 H N N 173 
ARG HH12 H N N 174 
ARG HH21 H N N 175 
ARG HH22 H N N 176 
ARG HXT  H N N 177 
ASN N    N N N 178 
ASN CA   C N S 179 
ASN C    C N N 180 
ASN O    O N N 181 
ASN CB   C N N 182 
ASN CG   C N N 183 
ASN OD1  O N N 184 
ASN ND2  N N N 185 
ASN OXT  O N N 186 
ASN H    H N N 187 
ASN H2   H N N 188 
ASN HA   H N N 189 
ASN HB2  H N N 190 
ASN HB3  H N N 191 
ASN HD21 H N N 192 
ASN HD22 H N N 193 
ASN HXT  H N N 194 
ASP N    N N N 195 
ASP CA   C N S 196 
ASP C    C N N 197 
ASP O    O N N 198 
ASP CB   C N N 199 
ASP CG   C N N 200 
ASP OD1  O N N 201 
ASP OD2  O N N 202 
ASP OXT  O N N 203 
ASP H    H N N 204 
ASP H2   H N N 205 
ASP HA   H N N 206 
ASP HB2  H N N 207 
ASP HB3  H N N 208 
ASP HD2  H N N 209 
ASP HXT  H N N 210 
CYS N    N N N 211 
CYS CA   C N R 212 
CYS C    C N N 213 
CYS O    O N N 214 
CYS CB   C N N 215 
CYS SG   S N N 216 
CYS OXT  O N N 217 
CYS H    H N N 218 
CYS H2   H N N 219 
CYS HA   H N N 220 
CYS HB2  H N N 221 
CYS HB3  H N N 222 
CYS HG   H N N 223 
CYS HXT  H N N 224 
GLN N    N N N 225 
GLN CA   C N S 226 
GLN C    C N N 227 
GLN O    O N N 228 
GLN CB   C N N 229 
GLN CG   C N N 230 
GLN CD   C N N 231 
GLN OE1  O N N 232 
GLN NE2  N N N 233 
GLN OXT  O N N 234 
GLN H    H N N 235 
GLN H2   H N N 236 
GLN HA   H N N 237 
GLN HB2  H N N 238 
GLN HB3  H N N 239 
GLN HG2  H N N 240 
GLN HG3  H N N 241 
GLN HE21 H N N 242 
GLN HE22 H N N 243 
GLN HXT  H N N 244 
GLU N    N N N 245 
GLU CA   C N S 246 
GLU C    C N N 247 
GLU O    O N N 248 
GLU CB   C N N 249 
GLU CG   C N N 250 
GLU CD   C N N 251 
GLU OE1  O N N 252 
GLU OE2  O N N 253 
GLU OXT  O N N 254 
GLU H    H N N 255 
GLU H2   H N N 256 
GLU HA   H N N 257 
GLU HB2  H N N 258 
GLU HB3  H N N 259 
GLU HG2  H N N 260 
GLU HG3  H N N 261 
GLU HE2  H N N 262 
GLU HXT  H N N 263 
GLY N    N N N 264 
GLY CA   C N N 265 
GLY C    C N N 266 
GLY O    O N N 267 
GLY OXT  O N N 268 
GLY H    H N N 269 
GLY H2   H N N 270 
GLY HA2  H N N 271 
GLY HA3  H N N 272 
GLY HXT  H N N 273 
HIS N    N N N 274 
HIS CA   C N S 275 
HIS C    C N N 276 
HIS O    O N N 277 
HIS CB   C N N 278 
HIS CG   C Y N 279 
HIS ND1  N Y N 280 
HIS CD2  C Y N 281 
HIS CE1  C Y N 282 
HIS NE2  N Y N 283 
HIS OXT  O N N 284 
HIS H    H N N 285 
HIS H2   H N N 286 
HIS HA   H N N 287 
HIS HB2  H N N 288 
HIS HB3  H N N 289 
HIS HD1  H N N 290 
HIS HD2  H N N 291 
HIS HE1  H N N 292 
HIS HE2  H N N 293 
HIS HXT  H N N 294 
ILE N    N N N 295 
ILE CA   C N S 296 
ILE C    C N N 297 
ILE O    O N N 298 
ILE CB   C N S 299 
ILE CG1  C N N 300 
ILE CG2  C N N 301 
ILE CD1  C N N 302 
ILE OXT  O N N 303 
ILE H    H N N 304 
ILE H2   H N N 305 
ILE HA   H N N 306 
ILE HB   H N N 307 
ILE HG12 H N N 308 
ILE HG13 H N N 309 
ILE HG21 H N N 310 
ILE HG22 H N N 311 
ILE HG23 H N N 312 
ILE HD11 H N N 313 
ILE HD12 H N N 314 
ILE HD13 H N N 315 
ILE HXT  H N N 316 
LEU N    N N N 317 
LEU CA   C N S 318 
LEU C    C N N 319 
LEU O    O N N 320 
LEU CB   C N N 321 
LEU CG   C N N 322 
LEU CD1  C N N 323 
LEU CD2  C N N 324 
LEU OXT  O N N 325 
LEU H    H N N 326 
LEU H2   H N N 327 
LEU HA   H N N 328 
LEU HB2  H N N 329 
LEU HB3  H N N 330 
LEU HG   H N N 331 
LEU HD11 H N N 332 
LEU HD12 H N N 333 
LEU HD13 H N N 334 
LEU HD21 H N N 335 
LEU HD22 H N N 336 
LEU HD23 H N N 337 
LEU HXT  H N N 338 
LYS N    N N N 339 
LYS CA   C N S 340 
LYS C    C N N 341 
LYS O    O N N 342 
LYS CB   C N N 343 
LYS CG   C N N 344 
LYS CD   C N N 345 
LYS CE   C N N 346 
LYS NZ   N N N 347 
LYS OXT  O N N 348 
LYS H    H N N 349 
LYS H2   H N N 350 
LYS HA   H N N 351 
LYS HB2  H N N 352 
LYS HB3  H N N 353 
LYS HG2  H N N 354 
LYS HG3  H N N 355 
LYS HD2  H N N 356 
LYS HD3  H N N 357 
LYS HE2  H N N 358 
LYS HE3  H N N 359 
LYS HZ1  H N N 360 
LYS HZ2  H N N 361 
LYS HZ3  H N N 362 
LYS HXT  H N N 363 
MET N    N N N 364 
MET CA   C N S 365 
MET C    C N N 366 
MET O    O N N 367 
MET CB   C N N 368 
MET CG   C N N 369 
MET SD   S N N 370 
MET CE   C N N 371 
MET OXT  O N N 372 
MET H    H N N 373 
MET H2   H N N 374 
MET HA   H N N 375 
MET HB2  H N N 376 
MET HB3  H N N 377 
MET HG2  H N N 378 
MET HG3  H N N 379 
MET HE1  H N N 380 
MET HE2  H N N 381 
MET HE3  H N N 382 
MET HXT  H N N 383 
NAG C1   C N R 384 
NAG C2   C N R 385 
NAG C3   C N R 386 
NAG C4   C N S 387 
NAG C5   C N R 388 
NAG C6   C N N 389 
NAG C7   C N N 390 
NAG C8   C N N 391 
NAG N2   N N N 392 
NAG O1   O N N 393 
NAG O3   O N N 394 
NAG O4   O N N 395 
NAG O5   O N N 396 
NAG O6   O N N 397 
NAG O7   O N N 398 
NAG H1   H N N 399 
NAG H2   H N N 400 
NAG H3   H N N 401 
NAG H4   H N N 402 
NAG H5   H N N 403 
NAG H61  H N N 404 
NAG H62  H N N 405 
NAG H81  H N N 406 
NAG H82  H N N 407 
NAG H83  H N N 408 
NAG HN2  H N N 409 
NAG HO1  H N N 410 
NAG HO3  H N N 411 
NAG HO4  H N N 412 
NAG HO6  H N N 413 
PHE N    N N N 414 
PHE CA   C N S 415 
PHE C    C N N 416 
PHE O    O N N 417 
PHE CB   C N N 418 
PHE CG   C Y N 419 
PHE CD1  C Y N 420 
PHE CD2  C Y N 421 
PHE CE1  C Y N 422 
PHE CE2  C Y N 423 
PHE CZ   C Y N 424 
PHE OXT  O N N 425 
PHE H    H N N 426 
PHE H2   H N N 427 
PHE HA   H N N 428 
PHE HB2  H N N 429 
PHE HB3  H N N 430 
PHE HD1  H N N 431 
PHE HD2  H N N 432 
PHE HE1  H N N 433 
PHE HE2  H N N 434 
PHE HZ   H N N 435 
PHE HXT  H N N 436 
PRO N    N N N 437 
PRO CA   C N S 438 
PRO C    C N N 439 
PRO O    O N N 440 
PRO CB   C N N 441 
PRO CG   C N N 442 
PRO CD   C N N 443 
PRO OXT  O N N 444 
PRO H    H N N 445 
PRO HA   H N N 446 
PRO HB2  H N N 447 
PRO HB3  H N N 448 
PRO HG2  H N N 449 
PRO HG3  H N N 450 
PRO HD2  H N N 451 
PRO HD3  H N N 452 
PRO HXT  H N N 453 
SER N    N N N 454 
SER CA   C N S 455 
SER C    C N N 456 
SER O    O N N 457 
SER CB   C N N 458 
SER OG   O N N 459 
SER OXT  O N N 460 
SER H    H N N 461 
SER H2   H N N 462 
SER HA   H N N 463 
SER HB2  H N N 464 
SER HB3  H N N 465 
SER HG   H N N 466 
SER HXT  H N N 467 
THR N    N N N 468 
THR CA   C N S 469 
THR C    C N N 470 
THR O    O N N 471 
THR CB   C N R 472 
THR OG1  O N N 473 
THR CG2  C N N 474 
THR OXT  O N N 475 
THR H    H N N 476 
THR H2   H N N 477 
THR HA   H N N 478 
THR HB   H N N 479 
THR HG1  H N N 480 
THR HG21 H N N 481 
THR HG22 H N N 482 
THR HG23 H N N 483 
THR HXT  H N N 484 
TRP N    N N N 485 
TRP CA   C N S 486 
TRP C    C N N 487 
TRP O    O N N 488 
TRP CB   C N N 489 
TRP CG   C Y N 490 
TRP CD1  C Y N 491 
TRP CD2  C Y N 492 
TRP NE1  N Y N 493 
TRP CE2  C Y N 494 
TRP CE3  C Y N 495 
TRP CZ2  C Y N 496 
TRP CZ3  C Y N 497 
TRP CH2  C Y N 498 
TRP OXT  O N N 499 
TRP H    H N N 500 
TRP H2   H N N 501 
TRP HA   H N N 502 
TRP HB2  H N N 503 
TRP HB3  H N N 504 
TRP HD1  H N N 505 
TRP HE1  H N N 506 
TRP HE3  H N N 507 
TRP HZ2  H N N 508 
TRP HZ3  H N N 509 
TRP HH2  H N N 510 
TRP HXT  H N N 511 
TYR N    N N N 512 
TYR CA   C N S 513 
TYR C    C N N 514 
TYR O    O N N 515 
TYR CB   C N N 516 
TYR CG   C Y N 517 
TYR CD1  C Y N 518 
TYR CD2  C Y N 519 
TYR CE1  C Y N 520 
TYR CE2  C Y N 521 
TYR CZ   C Y N 522 
TYR OH   O N N 523 
TYR OXT  O N N 524 
TYR H    H N N 525 
TYR H2   H N N 526 
TYR HA   H N N 527 
TYR HB2  H N N 528 
TYR HB3  H N N 529 
TYR HD1  H N N 530 
TYR HD2  H N N 531 
TYR HE1  H N N 532 
TYR HE2  H N N 533 
TYR HH   H N N 534 
TYR HXT  H N N 535 
VAL N    N N N 536 
VAL CA   C N S 537 
VAL C    C N N 538 
VAL O    O N N 539 
VAL CB   C N N 540 
VAL CG1  C N N 541 
VAL CG2  C N N 542 
VAL OXT  O N N 543 
VAL H    H N N 544 
VAL H2   H N N 545 
VAL HA   H N N 546 
VAL HB   H N N 547 
VAL HG11 H N N 548 
VAL HG12 H N N 549 
VAL HG13 H N N 550 
VAL HG21 H N N 551 
VAL HG22 H N N 552 
VAL HG23 H N N 553 
VAL HXT  H N N 554 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
6PL C26 C25  sing N N 1   
6PL C26 H261 sing N N 2   
6PL C26 H262 sing N N 3   
6PL C26 H263 sing N N 4   
6PL C25 C24  sing N N 5   
6PL C25 H251 sing N N 6   
6PL C25 H252 sing N N 7   
6PL C24 C23  sing N N 8   
6PL C24 H241 sing N N 9   
6PL C24 H242 sing N N 10  
6PL C23 C22  sing N N 11  
6PL C23 H231 sing N N 12  
6PL C23 H232 sing N N 13  
6PL C22 C21  sing N N 14  
6PL C22 H221 sing N N 15  
6PL C22 H222 sing N N 16  
6PL C21 C20  sing N N 17  
6PL C21 H211 sing N N 18  
6PL C21 H212 sing N N 19  
6PL C20 C19  sing N N 20  
6PL C20 H201 sing N N 21  
6PL C20 H202 sing N N 22  
6PL C19 C18  sing N N 23  
6PL C19 H191 sing N N 24  
6PL C19 H192 sing N N 25  
6PL C18 C17  sing N N 26  
6PL C18 H181 sing N N 27  
6PL C18 H182 sing N N 28  
6PL C17 C16  sing N N 29  
6PL C17 H171 sing N N 30  
6PL C17 H172 sing N N 31  
6PL C16 C15  sing N N 32  
6PL C16 H161 sing N N 33  
6PL C16 H162 sing N N 34  
6PL C15 C14  sing N N 35  
6PL C15 H151 sing N N 36  
6PL C15 H152 sing N N 37  
6PL C14 C13  sing N N 38  
6PL C14 H141 sing N N 39  
6PL C14 H142 sing N N 40  
6PL C13 C12  sing N N 41  
6PL C13 H131 sing N N 42  
6PL C13 H132 sing N N 43  
6PL C12 C11  sing N N 44  
6PL C12 H121 sing N N 45  
6PL C12 H122 sing N N 46  
6PL C11 O11  doub N N 47  
6PL C11 O3   sing N N 48  
6PL O3  C3   sing N N 49  
6PL C3  C2   sing N N 50  
6PL C3  H31  sing N N 51  
6PL C3  H32  sing N N 52  
6PL C2  C1   sing N N 53  
6PL C2  O2   sing N N 54  
6PL C2  H2   sing N N 55  
6PL C1  O3P  sing N N 56  
6PL C1  H11  sing N N 57  
6PL C1  H12  sing N N 58  
6PL O3P P    sing N N 59  
6PL P   O1P  doub N N 60  
6PL P   O2P  sing N N 61  
6PL P   O4P  sing N N 62  
6PL O2P H2P  sing N N 63  
6PL O4P C4   sing N N 64  
6PL C4  C5   sing N N 65  
6PL C4  H41  sing N N 66  
6PL C4  H42  sing N N 67  
6PL C5  N    sing N N 68  
6PL C5  H51  sing N N 69  
6PL C5  H52  sing N N 70  
6PL N   C7   sing N N 71  
6PL N   C8   sing N N 72  
6PL N   C6   sing N N 73  
6PL C7  H71  sing N N 74  
6PL C7  H72  sing N N 75  
6PL C7  H73  sing N N 76  
6PL C8  H81  sing N N 77  
6PL C8  H82  sing N N 78  
6PL C8  H83  sing N N 79  
6PL C6  H61  sing N N 80  
6PL C6  H62  sing N N 81  
6PL C6  H63  sing N N 82  
6PL O2  C31  sing N N 83  
6PL C31 O31  doub N N 84  
6PL C31 C32  sing N N 85  
6PL C32 C33  sing N N 86  
6PL C32 H321 sing N N 87  
6PL C32 H322 sing N N 88  
6PL C33 C34  sing N N 89  
6PL C33 H331 sing N N 90  
6PL C33 H332 sing N N 91  
6PL C34 C35  sing N N 92  
6PL C34 H341 sing N N 93  
6PL C34 H342 sing N N 94  
6PL C35 C36  sing N N 95  
6PL C35 H351 sing N N 96  
6PL C35 H352 sing N N 97  
6PL C36 C37  sing N N 98  
6PL C36 H361 sing N N 99  
6PL C36 H362 sing N N 100 
6PL C37 C38  sing N N 101 
6PL C37 H371 sing N N 102 
6PL C37 H372 sing N N 103 
6PL C38 C39  sing N N 104 
6PL C38 H381 sing N N 105 
6PL C38 H382 sing N N 106 
6PL C39 C40  sing N N 107 
6PL C39 H391 sing N N 108 
6PL C39 H392 sing N N 109 
6PL C40 C41  sing N N 110 
6PL C40 H401 sing N N 111 
6PL C40 H402 sing N N 112 
6PL C41 C42  sing N N 113 
6PL C41 H411 sing N N 114 
6PL C41 H412 sing N N 115 
6PL C42 C43  sing N N 116 
6PL C42 H421 sing N N 117 
6PL C42 H422 sing N N 118 
6PL C43 C44  sing N N 119 
6PL C43 H431 sing N N 120 
6PL C43 H432 sing N N 121 
6PL C44 C45  sing N N 122 
6PL C44 H441 sing N N 123 
6PL C44 H442 sing N N 124 
6PL C45 C46  sing N N 125 
6PL C45 H451 sing N N 126 
6PL C45 H452 sing N N 127 
6PL C46 C47  sing N N 128 
6PL C46 H461 sing N N 129 
6PL C46 H462 sing N N 130 
6PL C47 C48  sing N N 131 
6PL C47 H471 sing N N 132 
6PL C47 H472 sing N N 133 
6PL C48 H481 sing N N 134 
6PL C48 H482 sing N N 135 
6PL C48 H483 sing N N 136 
ALA N   CA   sing N N 137 
ALA N   H    sing N N 138 
ALA N   H2   sing N N 139 
ALA CA  C    sing N N 140 
ALA CA  CB   sing N N 141 
ALA CA  HA   sing N N 142 
ALA C   O    doub N N 143 
ALA C   OXT  sing N N 144 
ALA CB  HB1  sing N N 145 
ALA CB  HB2  sing N N 146 
ALA CB  HB3  sing N N 147 
ALA OXT HXT  sing N N 148 
ARG N   CA   sing N N 149 
ARG N   H    sing N N 150 
ARG N   H2   sing N N 151 
ARG CA  C    sing N N 152 
ARG CA  CB   sing N N 153 
ARG CA  HA   sing N N 154 
ARG C   O    doub N N 155 
ARG C   OXT  sing N N 156 
ARG CB  CG   sing N N 157 
ARG CB  HB2  sing N N 158 
ARG CB  HB3  sing N N 159 
ARG CG  CD   sing N N 160 
ARG CG  HG2  sing N N 161 
ARG CG  HG3  sing N N 162 
ARG CD  NE   sing N N 163 
ARG CD  HD2  sing N N 164 
ARG CD  HD3  sing N N 165 
ARG NE  CZ   sing N N 166 
ARG NE  HE   sing N N 167 
ARG CZ  NH1  sing N N 168 
ARG CZ  NH2  doub N N 169 
ARG NH1 HH11 sing N N 170 
ARG NH1 HH12 sing N N 171 
ARG NH2 HH21 sing N N 172 
ARG NH2 HH22 sing N N 173 
ARG OXT HXT  sing N N 174 
ASN N   CA   sing N N 175 
ASN N   H    sing N N 176 
ASN N   H2   sing N N 177 
ASN CA  C    sing N N 178 
ASN CA  CB   sing N N 179 
ASN CA  HA   sing N N 180 
ASN C   O    doub N N 181 
ASN C   OXT  sing N N 182 
ASN CB  CG   sing N N 183 
ASN CB  HB2  sing N N 184 
ASN CB  HB3  sing N N 185 
ASN CG  OD1  doub N N 186 
ASN CG  ND2  sing N N 187 
ASN ND2 HD21 sing N N 188 
ASN ND2 HD22 sing N N 189 
ASN OXT HXT  sing N N 190 
ASP N   CA   sing N N 191 
ASP N   H    sing N N 192 
ASP N   H2   sing N N 193 
ASP CA  C    sing N N 194 
ASP CA  CB   sing N N 195 
ASP CA  HA   sing N N 196 
ASP C   O    doub N N 197 
ASP C   OXT  sing N N 198 
ASP CB  CG   sing N N 199 
ASP CB  HB2  sing N N 200 
ASP CB  HB3  sing N N 201 
ASP CG  OD1  doub N N 202 
ASP CG  OD2  sing N N 203 
ASP OD2 HD2  sing N N 204 
ASP OXT HXT  sing N N 205 
CYS N   CA   sing N N 206 
CYS N   H    sing N N 207 
CYS N   H2   sing N N 208 
CYS CA  C    sing N N 209 
CYS CA  CB   sing N N 210 
CYS CA  HA   sing N N 211 
CYS C   O    doub N N 212 
CYS C   OXT  sing N N 213 
CYS CB  SG   sing N N 214 
CYS CB  HB2  sing N N 215 
CYS CB  HB3  sing N N 216 
CYS SG  HG   sing N N 217 
CYS OXT HXT  sing N N 218 
GLN N   CA   sing N N 219 
GLN N   H    sing N N 220 
GLN N   H2   sing N N 221 
GLN CA  C    sing N N 222 
GLN CA  CB   sing N N 223 
GLN CA  HA   sing N N 224 
GLN C   O    doub N N 225 
GLN C   OXT  sing N N 226 
GLN CB  CG   sing N N 227 
GLN CB  HB2  sing N N 228 
GLN CB  HB3  sing N N 229 
GLN CG  CD   sing N N 230 
GLN CG  HG2  sing N N 231 
GLN CG  HG3  sing N N 232 
GLN CD  OE1  doub N N 233 
GLN CD  NE2  sing N N 234 
GLN NE2 HE21 sing N N 235 
GLN NE2 HE22 sing N N 236 
GLN OXT HXT  sing N N 237 
GLU N   CA   sing N N 238 
GLU N   H    sing N N 239 
GLU N   H2   sing N N 240 
GLU CA  C    sing N N 241 
GLU CA  CB   sing N N 242 
GLU CA  HA   sing N N 243 
GLU C   O    doub N N 244 
GLU C   OXT  sing N N 245 
GLU CB  CG   sing N N 246 
GLU CB  HB2  sing N N 247 
GLU CB  HB3  sing N N 248 
GLU CG  CD   sing N N 249 
GLU CG  HG2  sing N N 250 
GLU CG  HG3  sing N N 251 
GLU CD  OE1  doub N N 252 
GLU CD  OE2  sing N N 253 
GLU OE2 HE2  sing N N 254 
GLU OXT HXT  sing N N 255 
GLY N   CA   sing N N 256 
GLY N   H    sing N N 257 
GLY N   H2   sing N N 258 
GLY CA  C    sing N N 259 
GLY CA  HA2  sing N N 260 
GLY CA  HA3  sing N N 261 
GLY C   O    doub N N 262 
GLY C   OXT  sing N N 263 
GLY OXT HXT  sing N N 264 
HIS N   CA   sing N N 265 
HIS N   H    sing N N 266 
HIS N   H2   sing N N 267 
HIS CA  C    sing N N 268 
HIS CA  CB   sing N N 269 
HIS CA  HA   sing N N 270 
HIS C   O    doub N N 271 
HIS C   OXT  sing N N 272 
HIS CB  CG   sing N N 273 
HIS CB  HB2  sing N N 274 
HIS CB  HB3  sing N N 275 
HIS CG  ND1  sing Y N 276 
HIS CG  CD2  doub Y N 277 
HIS ND1 CE1  doub Y N 278 
HIS ND1 HD1  sing N N 279 
HIS CD2 NE2  sing Y N 280 
HIS CD2 HD2  sing N N 281 
HIS CE1 NE2  sing Y N 282 
HIS CE1 HE1  sing N N 283 
HIS NE2 HE2  sing N N 284 
HIS OXT HXT  sing N N 285 
ILE N   CA   sing N N 286 
ILE N   H    sing N N 287 
ILE N   H2   sing N N 288 
ILE CA  C    sing N N 289 
ILE CA  CB   sing N N 290 
ILE CA  HA   sing N N 291 
ILE C   O    doub N N 292 
ILE C   OXT  sing N N 293 
ILE CB  CG1  sing N N 294 
ILE CB  CG2  sing N N 295 
ILE CB  HB   sing N N 296 
ILE CG1 CD1  sing N N 297 
ILE CG1 HG12 sing N N 298 
ILE CG1 HG13 sing N N 299 
ILE CG2 HG21 sing N N 300 
ILE CG2 HG22 sing N N 301 
ILE CG2 HG23 sing N N 302 
ILE CD1 HD11 sing N N 303 
ILE CD1 HD12 sing N N 304 
ILE CD1 HD13 sing N N 305 
ILE OXT HXT  sing N N 306 
LEU N   CA   sing N N 307 
LEU N   H    sing N N 308 
LEU N   H2   sing N N 309 
LEU CA  C    sing N N 310 
LEU CA  CB   sing N N 311 
LEU CA  HA   sing N N 312 
LEU C   O    doub N N 313 
LEU C   OXT  sing N N 314 
LEU CB  CG   sing N N 315 
LEU CB  HB2  sing N N 316 
LEU CB  HB3  sing N N 317 
LEU CG  CD1  sing N N 318 
LEU CG  CD2  sing N N 319 
LEU CG  HG   sing N N 320 
LEU CD1 HD11 sing N N 321 
LEU CD1 HD12 sing N N 322 
LEU CD1 HD13 sing N N 323 
LEU CD2 HD21 sing N N 324 
LEU CD2 HD22 sing N N 325 
LEU CD2 HD23 sing N N 326 
LEU OXT HXT  sing N N 327 
LYS N   CA   sing N N 328 
LYS N   H    sing N N 329 
LYS N   H2   sing N N 330 
LYS CA  C    sing N N 331 
LYS CA  CB   sing N N 332 
LYS CA  HA   sing N N 333 
LYS C   O    doub N N 334 
LYS C   OXT  sing N N 335 
LYS CB  CG   sing N N 336 
LYS CB  HB2  sing N N 337 
LYS CB  HB3  sing N N 338 
LYS CG  CD   sing N N 339 
LYS CG  HG2  sing N N 340 
LYS CG  HG3  sing N N 341 
LYS CD  CE   sing N N 342 
LYS CD  HD2  sing N N 343 
LYS CD  HD3  sing N N 344 
LYS CE  NZ   sing N N 345 
LYS CE  HE2  sing N N 346 
LYS CE  HE3  sing N N 347 
LYS NZ  HZ1  sing N N 348 
LYS NZ  HZ2  sing N N 349 
LYS NZ  HZ3  sing N N 350 
LYS OXT HXT  sing N N 351 
MET N   CA   sing N N 352 
MET N   H    sing N N 353 
MET N   H2   sing N N 354 
MET CA  C    sing N N 355 
MET CA  CB   sing N N 356 
MET CA  HA   sing N N 357 
MET C   O    doub N N 358 
MET C   OXT  sing N N 359 
MET CB  CG   sing N N 360 
MET CB  HB2  sing N N 361 
MET CB  HB3  sing N N 362 
MET CG  SD   sing N N 363 
MET CG  HG2  sing N N 364 
MET CG  HG3  sing N N 365 
MET SD  CE   sing N N 366 
MET CE  HE1  sing N N 367 
MET CE  HE2  sing N N 368 
MET CE  HE3  sing N N 369 
MET OXT HXT  sing N N 370 
NAG C1  C2   sing N N 371 
NAG C1  O1   sing N N 372 
NAG C1  O5   sing N N 373 
NAG C1  H1   sing N N 374 
NAG C2  C3   sing N N 375 
NAG C2  N2   sing N N 376 
NAG C2  H2   sing N N 377 
NAG C3  C4   sing N N 378 
NAG C3  O3   sing N N 379 
NAG C3  H3   sing N N 380 
NAG C4  C5   sing N N 381 
NAG C4  O4   sing N N 382 
NAG C4  H4   sing N N 383 
NAG C5  C6   sing N N 384 
NAG C5  O5   sing N N 385 
NAG C5  H5   sing N N 386 
NAG C6  O6   sing N N 387 
NAG C6  H61  sing N N 388 
NAG C6  H62  sing N N 389 
NAG C7  C8   sing N N 390 
NAG C7  N2   sing N N 391 
NAG C7  O7   doub N N 392 
NAG C8  H81  sing N N 393 
NAG C8  H82  sing N N 394 
NAG C8  H83  sing N N 395 
NAG N2  HN2  sing N N 396 
NAG O1  HO1  sing N N 397 
NAG O3  HO3  sing N N 398 
NAG O4  HO4  sing N N 399 
NAG O6  HO6  sing N N 400 
PHE N   CA   sing N N 401 
PHE N   H    sing N N 402 
PHE N   H2   sing N N 403 
PHE CA  C    sing N N 404 
PHE CA  CB   sing N N 405 
PHE CA  HA   sing N N 406 
PHE C   O    doub N N 407 
PHE C   OXT  sing N N 408 
PHE CB  CG   sing N N 409 
PHE CB  HB2  sing N N 410 
PHE CB  HB3  sing N N 411 
PHE CG  CD1  doub Y N 412 
PHE CG  CD2  sing Y N 413 
PHE CD1 CE1  sing Y N 414 
PHE CD1 HD1  sing N N 415 
PHE CD2 CE2  doub Y N 416 
PHE CD2 HD2  sing N N 417 
PHE CE1 CZ   doub Y N 418 
PHE CE1 HE1  sing N N 419 
PHE CE2 CZ   sing Y N 420 
PHE CE2 HE2  sing N N 421 
PHE CZ  HZ   sing N N 422 
PHE OXT HXT  sing N N 423 
PRO N   CA   sing N N 424 
PRO N   CD   sing N N 425 
PRO N   H    sing N N 426 
PRO CA  C    sing N N 427 
PRO CA  CB   sing N N 428 
PRO CA  HA   sing N N 429 
PRO C   O    doub N N 430 
PRO C   OXT  sing N N 431 
PRO CB  CG   sing N N 432 
PRO CB  HB2  sing N N 433 
PRO CB  HB3  sing N N 434 
PRO CG  CD   sing N N 435 
PRO CG  HG2  sing N N 436 
PRO CG  HG3  sing N N 437 
PRO CD  HD2  sing N N 438 
PRO CD  HD3  sing N N 439 
PRO OXT HXT  sing N N 440 
SER N   CA   sing N N 441 
SER N   H    sing N N 442 
SER N   H2   sing N N 443 
SER CA  C    sing N N 444 
SER CA  CB   sing N N 445 
SER CA  HA   sing N N 446 
SER C   O    doub N N 447 
SER C   OXT  sing N N 448 
SER CB  OG   sing N N 449 
SER CB  HB2  sing N N 450 
SER CB  HB3  sing N N 451 
SER OG  HG   sing N N 452 
SER OXT HXT  sing N N 453 
THR N   CA   sing N N 454 
THR N   H    sing N N 455 
THR N   H2   sing N N 456 
THR CA  C    sing N N 457 
THR CA  CB   sing N N 458 
THR CA  HA   sing N N 459 
THR C   O    doub N N 460 
THR C   OXT  sing N N 461 
THR CB  OG1  sing N N 462 
THR CB  CG2  sing N N 463 
THR CB  HB   sing N N 464 
THR OG1 HG1  sing N N 465 
THR CG2 HG21 sing N N 466 
THR CG2 HG22 sing N N 467 
THR CG2 HG23 sing N N 468 
THR OXT HXT  sing N N 469 
TRP N   CA   sing N N 470 
TRP N   H    sing N N 471 
TRP N   H2   sing N N 472 
TRP CA  C    sing N N 473 
TRP CA  CB   sing N N 474 
TRP CA  HA   sing N N 475 
TRP C   O    doub N N 476 
TRP C   OXT  sing N N 477 
TRP CB  CG   sing N N 478 
TRP CB  HB2  sing N N 479 
TRP CB  HB3  sing N N 480 
TRP CG  CD1  doub Y N 481 
TRP CG  CD2  sing Y N 482 
TRP CD1 NE1  sing Y N 483 
TRP CD1 HD1  sing N N 484 
TRP CD2 CE2  doub Y N 485 
TRP CD2 CE3  sing Y N 486 
TRP NE1 CE2  sing Y N 487 
TRP NE1 HE1  sing N N 488 
TRP CE2 CZ2  sing Y N 489 
TRP CE3 CZ3  doub Y N 490 
TRP CE3 HE3  sing N N 491 
TRP CZ2 CH2  doub Y N 492 
TRP CZ2 HZ2  sing N N 493 
TRP CZ3 CH2  sing Y N 494 
TRP CZ3 HZ3  sing N N 495 
TRP CH2 HH2  sing N N 496 
TRP OXT HXT  sing N N 497 
TYR N   CA   sing N N 498 
TYR N   H    sing N N 499 
TYR N   H2   sing N N 500 
TYR CA  C    sing N N 501 
TYR CA  CB   sing N N 502 
TYR CA  HA   sing N N 503 
TYR C   O    doub N N 504 
TYR C   OXT  sing N N 505 
TYR CB  CG   sing N N 506 
TYR CB  HB2  sing N N 507 
TYR CB  HB3  sing N N 508 
TYR CG  CD1  doub Y N 509 
TYR CG  CD2  sing Y N 510 
TYR CD1 CE1  sing Y N 511 
TYR CD1 HD1  sing N N 512 
TYR CD2 CE2  doub Y N 513 
TYR CD2 HD2  sing N N 514 
TYR CE1 CZ   doub Y N 515 
TYR CE1 HE1  sing N N 516 
TYR CE2 CZ   sing Y N 517 
TYR CE2 HE2  sing N N 518 
TYR CZ  OH   sing N N 519 
TYR OH  HH   sing N N 520 
TYR OXT HXT  sing N N 521 
VAL N   CA   sing N N 522 
VAL N   H    sing N N 523 
VAL N   H2   sing N N 524 
VAL CA  C    sing N N 525 
VAL CA  CB   sing N N 526 
VAL CA  HA   sing N N 527 
VAL C   O    doub N N 528 
VAL C   OXT  sing N N 529 
VAL CB  CG1  sing N N 530 
VAL CB  CG2  sing N N 531 
VAL CB  HB   sing N N 532 
VAL CG1 HG11 sing N N 533 
VAL CG1 HG12 sing N N 534 
VAL CG1 HG13 sing N N 535 
VAL CG2 HG21 sing N N 536 
VAL CG2 HG22 sing N N 537 
VAL CG2 HG23 sing N N 538 
VAL OXT HXT  sing N N 539 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-05-20 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           9BVQ 
_em_admin.last_update        2025-03-26 
_em_admin.map_release_date   2025-01-22 
_em_admin.title              'Vitamin K-dependent gamma-carboxylase with TMG2 propeptide and glutamate-rich region' 
# 
loop_
_em_buffer_component.buffer_id 
_em_buffer_component.concentration 
_em_buffer_component.concentration_units 
_em_buffer_component.formula 
_em_buffer_component.id 
_em_buffer_component.name 
1 150   mM NaCl       1 'Sodium chloride' 
1 20    mM C8H18N2O4S 2 HEPES             
1 0.005 %  C56H92O25  3 Glyco-diosgenin   
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                MEGADALTONS 
_em_entity_assembly_molwt.value                0.1125 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 HEK293S 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              'pEG BacMam' 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         50 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOQUANTUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    1 
_em_image_recording.num_real_images                     5935 
# 
_em_imaging_optics.chr_aberration_corrector   ? 
_em_imaging_optics.energyfilter_lower         ? 
_em_imaging_optics.energyfilter_slit_width    20 
_em_imaging_optics.energyfilter_name          'GIF Bioquantum' 
_em_imaging_optics.energyfilter_upper         ? 
_em_imaging_optics.id                         1 
_em_imaging_optics.imaging_id                 1 
_em_imaging_optics.phase_plate                ? 
_em_imaging_optics.sph_aberration_corrector   ? 
_em_imaging_optics.details                    ? 
# 
_em_particle_selection.details                  ? 
_em_particle_selection.id                       1 
_em_particle_selection.image_processing_id      1 
_em_particle_selection.method                   ? 
_em_particle_selection.num_particles_selected   608703 
_em_particle_selection.reference_model          ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'MODEL REFINEMENT'              ? 1  ? ? ? PHENIX 1.20.1_4487: 
'IMAGE ACQUISITION'             ? 2  1 1 1 ?      ?            
'PARTICLE SELECTION'            ? 3  1 1 1 ?      ?            
'VOLUME SELECTION'              ? 4  1 1 1 ?      ?            
CLASSIFICATION                  ? 5  1 1 1 ?      ?            
MASKING                         ? 6  1 1 1 ?      ?            
RECONSTRUCTION                  ? 7  1 1 1 ?      ?            
'INITIAL EULER ASSIGNMENT'      ? 8  1 1 1 ?      ?            
'FINAL EULER ASSIGNMENT'        ? 9  1 1 1 ?      ?            
'CTF CORRECTION'                ? 10 1 1 1 ?      ?            
'LAYERLINE INDEXING'            ? 11 1 1 1 ?      ?            
'DIFFRACTION INDEXING'          ? 12 1 1 1 ?      ?            
'MODEL FITTING'                 ? 13 1 1 1 ?      ?            
'SERIES ALIGNMENT'              ? 14 1 1 1 ?      ?            
'MOLECULAR REPLACEMENT'         ? 15 1 1 1 ?      ?            
'LATTICE DISTORTION CORRECTION' ? 16 1 1 1 ?      ?            
'SYMMETRY DETERMINATION'        ? 17 1 1 1 ?      ?            
'CRYSTALLOGRAPHY MERGING'       ? 18 1 1 1 ?      ?            
OTHER                           ? 19 1 1 1 ?      ?            
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI)'             'United States' HL121718 1 
'American Heart Association'                                                                      'United States' 
'Established Investigator Award' 2 
'American Heart Association'                                                                      'United States' 
'Collaborative Sciences Award'   3 
'W. M. Keck Foundation'                                                                           'United States' 
'Forefront of Science Award'     4 
'Childrens Discovery Institute of Washington University and St. Louis Childrens Hospital'         'United States' 'MCII 2020-854' 
5 
'National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)' 'United States' AI158500 6 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)'        'United States' GM131008 7 
# 
loop_
_pdbx_entity_branch_list.entity_id 
_pdbx_entity_branch_list.comp_id 
_pdbx_entity_branch_list.num 
_pdbx_entity_branch_list.hetero 
3 NAG 1 n 
3 NAG 2 n 
# 
_atom_sites.entry_id                    9BVQ 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
P 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ASP A 1 5   ? 163.040 164.233 120.956 1.00 103.14 ? 31  ASP A N   1 
ATOM   2    C CA  . ASP A 1 5   ? 164.222 164.404 121.793 1.00 103.98 ? 31  ASP A CA  1 
ATOM   3    C C   . ASP A 1 5   ? 163.889 165.184 123.060 1.00 100.89 ? 31  ASP A C   1 
ATOM   4    O O   . ASP A 1 5   ? 164.762 165.445 123.887 1.00 100.10 ? 31  ASP A O   1 
ATOM   5    C CB  . ASP A 1 5   ? 165.333 165.112 121.014 1.00 104.17 ? 31  ASP A CB  1 
ATOM   6    C CG  . ASP A 1 5   ? 165.822 164.301 119.830 1.00 104.80 ? 31  ASP A CG  1 
ATOM   7    O OD1 . ASP A 1 5   ? 165.821 163.055 119.920 1.00 103.86 ? 31  ASP A OD1 1 
ATOM   8    O OD2 . ASP A 1 5   ? 166.207 164.909 118.809 1.00 104.46 ? 31  ASP A OD2 1 
ATOM   9    N N   . SER A 1 6   ? 162.620 165.556 123.204 1.00 90.19  ? 32  SER A N   1 
ATOM   10   C CA  . SER A 1 6   ? 162.182 166.276 124.389 1.00 89.75  ? 32  SER A CA  1 
ATOM   11   C C   . SER A 1 6   ? 162.226 165.371 125.615 1.00 89.05  ? 32  SER A C   1 
ATOM   12   O O   . SER A 1 6   ? 162.080 164.150 125.521 1.00 92.63  ? 32  SER A O   1 
ATOM   13   C CB  . SER A 1 6   ? 160.768 166.821 124.192 1.00 91.74  ? 32  SER A CB  1 
ATOM   14   O OG  . SER A 1 6   ? 160.715 167.716 123.095 1.00 93.12  ? 32  SER A OG  1 
ATOM   15   N N   . ARG A 1 7   ? 162.438 165.989 126.778 1.00 86.75  ? 33  ARG A N   1 
ATOM   16   C CA  . ARG A 1 7   ? 162.486 165.225 128.021 1.00 91.69  ? 33  ARG A CA  1 
ATOM   17   C C   . ARG A 1 7   ? 161.128 164.618 128.350 1.00 91.62  ? 33  ARG A C   1 
ATOM   18   O O   . ARG A 1 7   ? 161.051 163.486 128.847 1.00 92.75  ? 33  ARG A O   1 
ATOM   19   C CB  . ARG A 1 7   ? 162.972 166.114 129.164 1.00 92.63  ? 33  ARG A CB  1 
ATOM   20   C CG  . ARG A 1 7   ? 164.381 166.647 128.970 1.00 91.70  ? 33  ARG A CG  1 
ATOM   21   C CD  . ARG A 1 7   ? 164.842 167.452 130.173 1.00 91.87  ? 33  ARG A CD  1 
ATOM   22   N NE  . ARG A 1 7   ? 166.211 167.928 130.013 1.00 93.04  ? 33  ARG A NE  1 
ATOM   23   C CZ  . ARG A 1 7   ? 166.876 168.622 130.927 1.00 92.98  ? 33  ARG A CZ  1 
ATOM   24   N NH1 . ARG A 1 7   ? 166.326 168.943 132.087 1.00 91.20  ? 33  ARG A NH1 1 
ATOM   25   N NH2 . ARG A 1 7   ? 168.124 169.003 130.671 1.00 92.34  ? 33  ARG A NH2 1 
ATOM   26   N N   . ILE A 1 8   ? 160.049 165.357 128.089 1.00 81.15  ? 34  ILE A N   1 
ATOM   27   C CA  . ILE A 1 8   ? 158.710 164.835 128.344 1.00 79.60  ? 34  ILE A CA  1 
ATOM   28   C C   . ILE A 1 8   ? 158.443 163.614 127.475 1.00 77.35  ? 34  ILE A C   1 
ATOM   29   O O   . ILE A 1 8   ? 157.875 162.617 127.937 1.00 80.37  ? 34  ILE A O   1 
ATOM   30   C CB  . ILE A 1 8   ? 157.652 165.932 128.123 1.00 80.59  ? 34  ILE A CB  1 
ATOM   31   C CG1 . ILE A 1 8   ? 157.634 166.917 129.297 1.00 83.02  ? 34  ILE A CG1 1 
ATOM   32   C CG2 . ILE A 1 8   ? 156.274 165.319 127.921 1.00 81.08  ? 34  ILE A CG2 1 
ATOM   33   C CD1 . ILE A 1 8   ? 158.685 168.009 129.220 1.00 81.42  ? 34  ILE A CD1 1 
ATOM   34   N N   . GLY A 1 9   ? 158.854 163.664 126.207 1.00 72.81  ? 35  GLY A N   1 
ATOM   35   C CA  . GLY A 1 9   ? 158.661 162.521 125.334 1.00 73.38  ? 35  GLY A CA  1 
ATOM   36   C C   . GLY A 1 9   ? 159.482 161.316 125.740 1.00 70.85  ? 35  GLY A C   1 
ATOM   37   O O   . GLY A 1 9   ? 159.082 160.176 125.486 1.00 73.71  ? 35  GLY A O   1 
ATOM   38   N N   . LYS A 1 10  ? 160.637 161.542 126.364 1.00 72.46  ? 36  LYS A N   1 
ATOM   39   C CA  . LYS A 1 10  ? 161.454 160.429 126.831 1.00 75.48  ? 36  LYS A CA  1 
ATOM   40   C C   . LYS A 1 10  ? 160.892 159.821 128.112 1.00 81.06  ? 36  LYS A C   1 
ATOM   41   O O   . LYS A 1 10  ? 160.941 158.600 128.295 1.00 79.14  ? 36  LYS A O   1 
ATOM   42   C CB  . LYS A 1 10  ? 162.895 160.890 127.044 1.00 76.94  ? 36  LYS A CB  1 
ATOM   43   C CG  . LYS A 1 10  ? 163.865 159.771 127.381 1.00 79.95  ? 36  LYS A CG  1 
ATOM   44   C CD  . LYS A 1 10  ? 165.284 160.297 127.524 1.00 81.30  ? 36  LYS A CD  1 
ATOM   45   C CE  . LYS A 1 10  ? 165.742 161.004 126.258 1.00 81.16  ? 36  LYS A CE  1 
ATOM   46   N NZ  . LYS A 1 10  ? 165.704 160.103 125.072 1.00 81.07  ? 36  LYS A NZ  1 
ATOM   47   N N   . LEU A 1 11  ? 160.358 160.654 129.007 1.00 82.31  ? 37  LEU A N   1 
ATOM   48   C CA  . LEU A 1 11  ? 159.809 160.149 130.262 1.00 75.98  ? 37  LEU A CA  1 
ATOM   49   C C   . LEU A 1 11  ? 158.452 159.486 130.053 1.00 75.99  ? 37  LEU A C   1 
ATOM   50   O O   . LEU A 1 11  ? 158.271 158.303 130.360 1.00 81.94  ? 37  LEU A O   1 
ATOM   51   C CB  . LEU A 1 11  ? 159.698 161.282 131.285 1.00 73.86  ? 37  LEU A CB  1 
ATOM   52   C CG  . LEU A 1 11  ? 161.008 161.845 131.834 1.00 77.66  ? 37  LEU A CG  1 
ATOM   53   C CD1 . LEU A 1 11  ? 160.731 162.928 132.864 1.00 78.45  ? 37  LEU A CD1 1 
ATOM   54   C CD2 . LEU A 1 11  ? 161.855 160.734 132.433 1.00 77.45  ? 37  LEU A CD2 1 
ATOM   55   N N   . LEU A 1 12  ? 157.483 160.237 129.529 1.00 67.84  ? 38  LEU A N   1 
ATOM   56   C CA  . LEU A 1 12  ? 156.118 159.747 129.402 1.00 67.70  ? 38  LEU A CA  1 
ATOM   57   C C   . LEU A 1 12  ? 155.902 158.885 128.165 1.00 71.97  ? 38  LEU A C   1 
ATOM   58   O O   . LEU A 1 12  ? 154.868 158.215 128.075 1.00 74.61  ? 38  LEU A O   1 
ATOM   59   C CB  . LEU A 1 12  ? 155.135 160.923 129.375 1.00 69.12  ? 38  LEU A CB  1 
ATOM   60   C CG  . LEU A 1 12  ? 154.952 161.772 130.637 1.00 73.14  ? 38  LEU A CG  1 
ATOM   61   C CD1 . LEU A 1 12  ? 156.071 162.792 130.806 1.00 74.18  ? 38  LEU A CD1 1 
ATOM   62   C CD2 . LEU A 1 12  ? 153.597 162.464 130.617 1.00 74.22  ? 38  LEU A CD2 1 
ATOM   63   N N   . GLY A 1 13  ? 156.839 158.883 127.220 1.00 71.86  ? 39  GLY A N   1 
ATOM   64   C CA  . GLY A 1 13  ? 156.708 158.089 126.017 1.00 70.49  ? 39  GLY A CA  1 
ATOM   65   C C   . GLY A 1 13  ? 155.884 158.708 124.911 1.00 71.54  ? 39  GLY A C   1 
ATOM   66   O O   . GLY A 1 13  ? 155.717 158.076 123.861 1.00 72.94  ? 39  GLY A O   1 
ATOM   67   N N   . PHE A 1 14  ? 155.362 159.917 125.104 1.00 71.01  ? 40  PHE A N   1 
ATOM   68   C CA  . PHE A 1 14  ? 154.575 160.582 124.078 1.00 67.57  ? 40  PHE A CA  1 
ATOM   69   C C   . PHE A 1 14  ? 154.795 162.084 124.176 1.00 72.37  ? 40  PHE A C   1 
ATOM   70   O O   . PHE A 1 14  ? 155.144 162.613 125.235 1.00 77.51  ? 40  PHE A O   1 
ATOM   71   C CB  . PHE A 1 14  ? 153.085 160.246 124.206 1.00 66.27  ? 40  PHE A CB  1 
ATOM   72   C CG  . PHE A 1 14  ? 152.429 160.839 125.418 1.00 69.39  ? 40  PHE A CG  1 
ATOM   73   C CD1 . PHE A 1 14  ? 152.571 160.246 126.659 1.00 71.67  ? 40  PHE A CD1 1 
ATOM   74   C CD2 . PHE A 1 14  ? 151.662 161.985 125.314 1.00 76.25  ? 40  PHE A CD2 1 
ATOM   75   C CE1 . PHE A 1 14  ? 151.965 160.789 127.774 1.00 74.88  ? 40  PHE A CE1 1 
ATOM   76   C CE2 . PHE A 1 14  ? 151.055 162.533 126.426 1.00 77.30  ? 40  PHE A CE2 1 
ATOM   77   C CZ  . PHE A 1 14  ? 151.207 161.933 127.657 1.00 75.15  ? 40  PHE A CZ  1 
ATOM   78   N N   . GLU A 1 15  ? 154.586 162.767 123.057 1.00 78.63  ? 41  GLU A N   1 
ATOM   79   C CA  . GLU A 1 15  ? 154.735 164.213 122.997 1.00 80.97  ? 41  GLU A CA  1 
ATOM   80   C C   . GLU A 1 15  ? 153.409 164.904 123.298 1.00 84.61  ? 41  GLU A C   1 
ATOM   81   O O   . GLU A 1 15  ? 152.335 164.300 123.241 1.00 86.06  ? 41  GLU A O   1 
ATOM   82   C CB  . GLU A 1 15  ? 155.251 164.645 121.624 1.00 81.59  ? 41  GLU A CB  1 
ATOM   83   C CG  . GLU A 1 15  ? 156.645 164.141 121.291 1.00 85.65  ? 41  GLU A CG  1 
ATOM   84   C CD  . GLU A 1 15  ? 157.729 164.839 122.091 1.00 88.81  ? 41  GLU A CD  1 
ATOM   85   O OE1 . GLU A 1 15  ? 157.456 165.923 122.648 1.00 90.01  ? 41  GLU A OE1 1 
ATOM   86   O OE2 . GLU A 1 15  ? 158.854 164.302 122.164 1.00 86.02  ? 41  GLU A OE2 1 
ATOM   87   N N   . TRP A 1 16  ? 153.499 166.196 123.623 1.00 85.48  ? 42  TRP A N   1 
ATOM   88   C CA  . TRP A 1 16  ? 152.297 166.967 123.925 1.00 84.29  ? 42  TRP A CA  1 
ATOM   89   C C   . TRP A 1 16  ? 151.434 167.176 122.689 1.00 83.93  ? 42  TRP A C   1 
ATOM   90   O O   . TRP A 1 16  ? 150.201 167.145 122.783 1.00 87.00  ? 42  TRP A O   1 
ATOM   91   C CB  . TRP A 1 16  ? 152.672 168.315 124.539 1.00 85.74  ? 42  TRP A CB  1 
ATOM   92   C CG  . TRP A 1 16  ? 153.340 168.205 125.873 1.00 87.77  ? 42  TRP A CG  1 
ATOM   93   C CD1 . TRP A 1 16  ? 154.638 168.504 126.166 1.00 88.73  ? 42  TRP A CD1 1 
ATOM   94   C CD2 . TRP A 1 16  ? 152.744 167.758 127.096 1.00 89.76  ? 42  TRP A CD2 1 
ATOM   95   N NE1 . TRP A 1 16  ? 154.886 168.277 127.498 1.00 91.02  ? 42  TRP A NE1 1 
ATOM   96   C CE2 . TRP A 1 16  ? 153.740 167.816 128.091 1.00 91.84  ? 42  TRP A CE2 1 
ATOM   97   C CE3 . TRP A 1 16  ? 151.465 167.316 127.448 1.00 88.66  ? 42  TRP A CE3 1 
ATOM   98   C CZ2 . TRP A 1 16  ? 153.497 167.449 129.413 1.00 90.16  ? 42  TRP A CZ2 1 
ATOM   99   C CZ3 . TRP A 1 16  ? 151.226 166.952 128.761 1.00 88.94  ? 42  TRP A CZ3 1 
ATOM   100  C CH2 . TRP A 1 16  ? 152.237 167.021 129.727 1.00 89.55  ? 42  TRP A CH2 1 
ATOM   101  N N   . THR A 1 17  ? 152.058 167.379 121.525 1.00 74.94  ? 43  THR A N   1 
ATOM   102  C CA  . THR A 1 17  ? 151.303 167.609 120.299 1.00 78.64  ? 43  THR A CA  1 
ATOM   103  C C   . THR A 1 17  ? 150.435 166.418 119.917 1.00 81.08  ? 43  THR A C   1 
ATOM   104  O O   . THR A 1 17  ? 149.495 166.579 119.132 1.00 79.86  ? 43  THR A O   1 
ATOM   105  C CB  . THR A 1 17  ? 152.255 167.946 119.150 1.00 80.07  ? 43  THR A CB  1 
ATOM   106  O OG1 . THR A 1 17  ? 151.507 168.104 117.938 1.00 81.58  ? 43  THR A OG1 1 
ATOM   107  C CG2 . THR A 1 17  ? 153.283 166.841 118.966 1.00 79.06  ? 43  THR A CG2 1 
ATOM   108  N N   . ASP A 1 18  ? 150.728 165.229 120.450 1.00 81.46  ? 44  ASP A N   1 
ATOM   109  C CA  . ASP A 1 18  ? 149.883 164.069 120.204 1.00 77.02  ? 44  ASP A CA  1 
ATOM   110  C C   . ASP A 1 18  ? 148.509 164.205 120.846 1.00 79.38  ? 44  ASP A C   1 
ATOM   111  O O   . ASP A 1 18  ? 147.581 163.493 120.450 1.00 83.49  ? 44  ASP A O   1 
ATOM   112  C CB  . ASP A 1 18  ? 150.571 162.802 120.712 1.00 80.71  ? 44  ASP A CB  1 
ATOM   113  C CG  . ASP A 1 18  ? 151.919 162.571 120.060 1.00 84.25  ? 44  ASP A CG  1 
ATOM   114  O OD1 . ASP A 1 18  ? 152.090 162.971 118.890 1.00 81.86  ? 44  ASP A OD1 1 
ATOM   115  O OD2 . ASP A 1 18  ? 152.808 161.989 120.716 1.00 85.37  ? 44  ASP A OD2 1 
ATOM   116  N N   . LEU A 1 19  ? 148.356 165.099 121.822 1.00 74.03  ? 45  LEU A N   1 
ATOM   117  C CA  . LEU A 1 19  ? 147.085 165.309 122.500 1.00 73.18  ? 45  LEU A CA  1 
ATOM   118  C C   . LEU A 1 19  ? 146.339 166.531 121.983 1.00 73.95  ? 45  LEU A C   1 
ATOM   119  O O   . LEU A 1 19  ? 145.334 166.929 122.581 1.00 75.82  ? 45  LEU A O   1 
ATOM   120  C CB  . LEU A 1 19  ? 147.305 165.435 124.008 1.00 71.82  ? 45  LEU A CB  1 
ATOM   121  C CG  . LEU A 1 19  ? 147.891 164.217 124.723 1.00 75.15  ? 45  LEU A CG  1 
ATOM   122  C CD1 . LEU A 1 19  ? 148.045 164.493 126.210 1.00 73.96  ? 45  LEU A CD1 1 
ATOM   123  C CD2 . LEU A 1 19  ? 147.022 162.994 124.491 1.00 75.98  ? 45  LEU A CD2 1 
ATOM   124  N N   . SER A 1 20  ? 146.806 167.136 120.890 1.00 74.68  ? 46  SER A N   1 
ATOM   125  C CA  . SER A 1 20  ? 146.191 168.367 120.405 1.00 74.90  ? 46  SER A CA  1 
ATOM   126  C C   . SER A 1 20  ? 144.808 168.113 119.816 1.00 77.13  ? 46  SER A C   1 
ATOM   127  O O   . SER A 1 20  ? 143.871 168.878 120.071 1.00 77.52  ? 46  SER A O   1 
ATOM   128  C CB  . SER A 1 20  ? 147.099 169.034 119.374 1.00 73.19  ? 46  SER A CB  1 
ATOM   129  O OG  . SER A 1 20  ? 147.311 168.187 118.259 1.00 76.84  ? 46  SER A OG  1 
ATOM   130  N N   . SER A 1 21  ? 144.658 167.051 119.030 1.00 72.82  ? 47  SER A N   1 
ATOM   131  C CA  . SER A 1 21  ? 143.408 166.767 118.340 1.00 70.82  ? 47  SER A CA  1 
ATOM   132  C C   . SER A 1 21  ? 143.034 165.302 118.521 1.00 72.03  ? 47  SER A C   1 
ATOM   133  O O   . SER A 1 21  ? 143.827 164.485 118.997 1.00 78.03  ? 47  SER A O   1 
ATOM   134  C CB  . SER A 1 21  ? 143.505 167.110 116.847 1.00 72.66  ? 47  SER A CB  1 
ATOM   135  O OG  . SER A 1 21  ? 142.279 166.851 116.186 1.00 74.75  ? 47  SER A OG  1 
ATOM   136  N N   . TRP A 1 22  ? 141.798 164.980 118.133 1.00 60.67  ? 48  TRP A N   1 
ATOM   137  C CA  . TRP A 1 22  ? 141.301 163.615 118.277 1.00 61.42  ? 48  TRP A CA  1 
ATOM   138  C C   . TRP A 1 22  ? 142.015 162.657 117.333 1.00 67.37  ? 48  TRP A C   1 
ATOM   139  O O   . TRP A 1 22  ? 142.319 161.518 117.709 1.00 73.22  ? 48  TRP A O   1 
ATOM   140  C CB  . TRP A 1 22  ? 139.792 163.583 118.038 1.00 62.78  ? 48  TRP A CB  1 
ATOM   141  C CG  . TRP A 1 22  ? 139.205 162.207 118.021 1.00 62.33  ? 48  TRP A CG  1 
ATOM   142  C CD1 . TRP A 1 22  ? 138.721 161.538 116.937 1.00 65.40  ? 48  TRP A CD1 1 
ATOM   143  C CD2 . TRP A 1 22  ? 139.040 161.329 119.141 1.00 63.48  ? 48  TRP A CD2 1 
ATOM   144  N NE1 . TRP A 1 22  ? 138.263 160.299 117.311 1.00 65.67  ? 48  TRP A NE1 1 
ATOM   145  C CE2 . TRP A 1 22  ? 138.448 160.146 118.660 1.00 62.65  ? 48  TRP A CE2 1 
ATOM   146  C CE3 . TRP A 1 22  ? 139.335 161.429 120.503 1.00 68.81  ? 48  TRP A CE3 1 
ATOM   147  C CZ2 . TRP A 1 22  ? 138.146 159.072 119.490 1.00 64.88  ? 48  TRP A CZ2 1 
ATOM   148  C CZ3 . TRP A 1 22  ? 139.034 160.361 121.326 1.00 68.74  ? 48  TRP A CZ3 1 
ATOM   149  C CH2 . TRP A 1 22  ? 138.446 159.198 120.817 1.00 66.97  ? 48  TRP A CH2 1 
ATOM   150  N N   . ARG A 1 23  ? 142.294 163.099 116.104 1.00 70.95  ? 49  ARG A N   1 
ATOM   151  C CA  . ARG A 1 23  ? 142.953 162.226 115.139 1.00 71.85  ? 49  ARG A CA  1 
ATOM   152  C C   . ARG A 1 23  ? 144.356 161.855 115.599 1.00 70.67  ? 49  ARG A C   1 
ATOM   153  O O   . ARG A 1 23  ? 144.772 160.697 115.469 1.00 76.26  ? 49  ARG A O   1 
ATOM   154  C CB  . ARG A 1 23  ? 142.996 162.899 113.768 1.00 74.74  ? 49  ARG A CB  1 
ATOM   155  C CG  . ARG A 1 23  ? 143.613 162.045 112.674 1.00 78.01  ? 49  ARG A CG  1 
ATOM   156  C CD  . ARG A 1 23  ? 143.589 162.764 111.336 1.00 77.22  ? 49  ARG A CD  1 
ATOM   157  N NE  . ARG A 1 23  ? 144.156 161.950 110.268 1.00 79.86  ? 49  ARG A NE  1 
ATOM   158  C CZ  . ARG A 1 23  ? 144.230 162.325 108.998 1.00 79.80  ? 49  ARG A CZ  1 
ATOM   159  N NH1 . ARG A 1 23  ? 143.780 163.503 108.598 1.00 77.42  ? 49  ARG A NH1 1 
ATOM   160  N NH2 . ARG A 1 23  ? 144.770 161.498 108.107 1.00 79.05  ? 49  ARG A NH2 1 
ATOM   161  N N   . ARG A 1 24  ? 145.095 162.816 116.155 1.00 59.70  ? 50  ARG A N   1 
ATOM   162  C CA  . ARG A 1 24  ? 146.435 162.513 116.642 1.00 63.76  ? 50  ARG A CA  1 
ATOM   163  C C   . ARG A 1 24  ? 146.397 161.598 117.858 1.00 66.66  ? 50  ARG A C   1 
ATOM   164  O O   . ARG A 1 24  ? 147.266 160.733 118.006 1.00 73.17  ? 50  ARG A O   1 
ATOM   165  C CB  . ARG A 1 24  ? 147.183 163.806 116.962 1.00 65.98  ? 50  ARG A CB  1 
ATOM   166  C CG  . ARG A 1 24  ? 147.472 164.660 115.739 1.00 67.77  ? 50  ARG A CG  1 
ATOM   167  C CD  . ARG A 1 24  ? 148.282 165.893 116.096 1.00 69.88  ? 50  ARG A CD  1 
ATOM   168  N NE  . ARG A 1 24  ? 148.597 166.694 114.919 1.00 72.91  ? 50  ARG A NE  1 
ATOM   169  C CZ  . ARG A 1 24  ? 149.284 167.827 114.946 1.00 70.95  ? 50  ARG A CZ  1 
ATOM   170  N NH1 . ARG A 1 24  ? 149.747 168.329 116.079 1.00 69.66  ? 50  ARG A NH1 1 
ATOM   171  N NH2 . ARG A 1 24  ? 149.513 168.474 113.806 1.00 69.08  ? 50  ARG A NH2 1 
ATOM   172  N N   . LEU A 1 25  ? 145.397 161.757 118.728 1.00 55.79  ? 51  LEU A N   1 
ATOM   173  C CA  . LEU A 1 25  ? 145.259 160.845 119.859 1.00 54.88  ? 51  LEU A CA  1 
ATOM   174  C C   . LEU A 1 25  ? 144.954 159.428 119.390 1.00 57.33  ? 51  LEU A C   1 
ATOM   175  O O   . LEU A 1 25  ? 145.503 158.457 119.926 1.00 63.44  ? 51  LEU A O   1 
ATOM   176  C CB  . LEU A 1 25  ? 144.172 161.345 120.808 1.00 56.50  ? 51  LEU A CB  1 
ATOM   177  C CG  . LEU A 1 25  ? 143.877 160.475 122.030 1.00 60.11  ? 51  LEU A CG  1 
ATOM   178  C CD1 . LEU A 1 25  ? 145.138 160.245 122.843 1.00 61.71  ? 51  LEU A CD1 1 
ATOM   179  C CD2 . LEU A 1 25  ? 142.799 161.117 122.886 1.00 61.70  ? 51  LEU A CD2 1 
ATOM   180  N N   . VAL A 1 26  ? 144.084 159.289 118.387 1.00 49.07  ? 52  VAL A N   1 
ATOM   181  C CA  . VAL A 1 26  ? 143.782 157.966 117.850 1.00 45.30  ? 52  VAL A CA  1 
ATOM   182  C C   . VAL A 1 26  ? 145.020 157.360 117.201 1.00 51.75  ? 52  VAL A C   1 
ATOM   183  O O   . VAL A 1 26  ? 145.282 156.159 117.336 1.00 61.62  ? 52  VAL A O   1 
ATOM   184  C CB  . VAL A 1 26  ? 142.602 158.044 116.865 1.00 49.08  ? 52  VAL A CB  1 
ATOM   185  C CG1 . VAL A 1 26  ? 142.388 156.707 116.186 1.00 52.67  ? 52  VAL A CG1 1 
ATOM   186  C CG2 . VAL A 1 26  ? 141.340 158.471 117.591 1.00 56.48  ? 52  VAL A CG2 1 
ATOM   187  N N   . THR A 1 27  ? 145.805 158.179 116.497 1.00 48.57  ? 53  THR A N   1 
ATOM   188  C CA  . THR A 1 27  ? 147.046 157.684 115.909 1.00 46.29  ? 53  THR A CA  1 
ATOM   189  C C   . THR A 1 27  ? 148.021 157.226 116.986 1.00 49.62  ? 53  THR A C   1 
ATOM   190  O O   . THR A 1 27  ? 148.699 156.204 116.829 1.00 57.61  ? 53  THR A O   1 
ATOM   191  C CB  . THR A 1 27  ? 147.680 158.766 115.036 1.00 46.67  ? 53  THR A CB  1 
ATOM   192  O OG1 . THR A 1 27  ? 146.762 159.148 114.005 1.00 53.21  ? 53  THR A OG1 1 
ATOM   193  C CG2 . THR A 1 27  ? 148.963 158.258 114.399 1.00 48.24  ? 53  THR A CG2 1 
ATOM   194  N N   . LEU A 1 28  ? 148.100 157.968 118.092 1.00 49.23  ? 54  LEU A N   1 
ATOM   195  C CA  . LEU A 1 28  ? 148.997 157.590 119.179 1.00 48.72  ? 54  LEU A CA  1 
ATOM   196  C C   . LEU A 1 28  ? 148.559 156.289 119.839 1.00 54.21  ? 54  LEU A C   1 
ATOM   197  O O   . LEU A 1 28  ? 149.393 155.424 120.131 1.00 60.61  ? 54  LEU A O   1 
ATOM   198  C CB  . LEU A 1 28  ? 149.067 158.714 120.212 1.00 50.14  ? 54  LEU A CB  1 
ATOM   199  C CG  . LEU A 1 28  ? 149.790 158.397 121.521 1.00 53.82  ? 54  LEU A CG  1 
ATOM   200  C CD1 . LEU A 1 28  ? 151.253 158.081 121.266 1.00 54.74  ? 54  LEU A CD1 1 
ATOM   201  C CD2 . LEU A 1 28  ? 149.650 159.547 122.504 1.00 57.26  ? 54  LEU A CD2 1 
ATOM   202  N N   . LEU A 1 29  ? 147.260 156.128 120.079 1.00 51.29  ? 55  LEU A N   1 
ATOM   203  C CA  . LEU A 1 29  ? 146.757 154.961 120.793 1.00 47.72  ? 55  LEU A CA  1 
ATOM   204  C C   . LEU A 1 29  ? 146.657 153.716 119.922 1.00 49.96  ? 55  LEU A C   1 
ATOM   205  O O   . LEU A 1 29  ? 146.177 152.685 120.405 1.00 58.15  ? 55  LEU A O   1 
ATOM   206  C CB  . LEU A 1 29  ? 145.390 155.266 121.409 1.00 45.37  ? 55  LEU A CB  1 
ATOM   207  C CG  . LEU A 1 29  ? 145.406 156.136 122.666 1.00 48.25  ? 55  LEU A CG  1 
ATOM   208  C CD1 . LEU A 1 29  ? 143.997 156.390 123.163 1.00 51.37  ? 55  LEU A CD1 1 
ATOM   209  C CD2 . LEU A 1 29  ? 146.244 155.485 123.751 1.00 51.85  ? 55  LEU A CD2 1 
ATOM   210  N N   . ASN A 1 30  ? 147.087 153.777 118.663 1.00 47.75  ? 56  ASN A N   1 
ATOM   211  C CA  . ASN A 1 30  ? 147.032 152.622 117.776 1.00 45.38  ? 56  ASN A CA  1 
ATOM   212  C C   . ASN A 1 30  ? 148.380 152.361 117.113 1.00 55.09  ? 56  ASN A C   1 
ATOM   213  O O   . ASN A 1 30  ? 148.440 151.789 116.022 1.00 59.45  ? 56  ASN A O   1 
ATOM   214  C CB  . ASN A 1 30  ? 145.942 152.799 116.722 1.00 44.40  ? 56  ASN A CB  1 
ATOM   215  C CG  . ASN A 1 30  ? 144.563 152.904 117.329 1.00 50.05  ? 56  ASN A CG  1 
ATOM   216  O OD1 . ASN A 1 30  ? 143.879 151.899 117.520 1.00 54.74  ? 56  ASN A OD1 1 
ATOM   217  N ND2 . ASN A 1 30  ? 144.143 154.124 117.638 1.00 56.64  ? 56  ASN A ND2 1 
ATOM   218  N N   . ARG A 1 31  ? 149.467 152.771 117.758 1.00 50.53  ? 57  ARG A N   1 
ATOM   219  C CA  . ARG A 1 31  ? 150.791 152.498 117.228 1.00 46.52  ? 57  ARG A CA  1 
ATOM   220  C C   . ARG A 1 31  ? 151.162 151.033 117.456 1.00 54.13  ? 57  ARG A C   1 
ATOM   221  O O   . ARG A 1 31  ? 150.730 150.419 118.436 1.00 59.53  ? 57  ARG A O   1 
ATOM   222  C CB  . ARG A 1 31  ? 151.826 153.408 117.882 1.00 49.62  ? 57  ARG A CB  1 
ATOM   223  C CG  . ARG A 1 31  ? 151.881 153.288 119.392 1.00 58.22  ? 57  ARG A CG  1 
ATOM   224  C CD  . ARG A 1 31  ? 152.650 154.438 120.018 1.00 57.24  ? 57  ARG A CD  1 
ATOM   225  N NE  . ARG A 1 31  ? 154.041 154.478 119.587 1.00 56.81  ? 57  ARG A NE  1 
ATOM   226  C CZ  . ARG A 1 31  ? 154.959 155.284 120.102 1.00 58.95  ? 57  ARG A CZ  1 
ATOM   227  N NH1 . ARG A 1 31  ? 154.667 156.127 121.078 1.00 54.87  ? 57  ARG A NH1 1 
ATOM   228  N NH2 . ARG A 1 31  ? 156.201 155.240 119.629 1.00 59.25  ? 57  ARG A NH2 1 
ATOM   229  N N   . PRO A 1 32  ? 151.951 150.447 116.560 1.00 54.18  ? 58  PRO A N   1 
ATOM   230  C CA  . PRO A 1 32  ? 152.333 149.041 116.722 1.00 54.70  ? 58  PRO A CA  1 
ATOM   231  C C   . PRO A 1 32  ? 153.231 148.824 117.931 1.00 53.13  ? 58  PRO A C   1 
ATOM   232  O O   . PRO A 1 32  ? 154.026 149.687 118.309 1.00 58.78  ? 58  PRO A O   1 
ATOM   233  C CB  . PRO A 1 32  ? 153.077 148.724 115.419 1.00 58.77  ? 58  PRO A CB  1 
ATOM   234  C CG  . PRO A 1 32  ? 152.607 149.757 114.450 1.00 58.23  ? 58  PRO A CG  1 
ATOM   235  C CD  . PRO A 1 32  ? 152.384 150.989 115.263 1.00 54.87  ? 58  PRO A CD  1 
ATOM   236  N N   . THR A 1 33  ? 153.101 147.639 118.527 1.00 52.91  ? 59  THR A N   1 
ATOM   237  C CA  . THR A 1 33  ? 153.906 147.240 119.673 1.00 53.97  ? 59  THR A CA  1 
ATOM   238  C C   . THR A 1 33  ? 154.149 145.738 119.606 1.00 56.21  ? 59  THR A C   1 
ATOM   239  O O   . THR A 1 33  ? 153.411 145.001 118.947 1.00 61.71  ? 59  THR A O   1 
ATOM   240  C CB  . THR A 1 33  ? 153.230 147.605 121.001 1.00 57.21  ? 59  THR A CB  1 
ATOM   241  O OG1 . THR A 1 33  ? 151.823 147.345 120.914 1.00 62.98  ? 59  THR A OG1 1 
ATOM   242  C CG2 . THR A 1 33  ? 153.457 149.069 121.349 1.00 57.47  ? 59  THR A CG2 1 
ATOM   243  N N   . ASP A 1 34  ? 155.199 145.293 120.292 1.00 48.54  ? 60  ASP A N   1 
ATOM   244  C CA  . ASP A 1 34  ? 155.507 143.869 120.332 1.00 47.05  ? 60  ASP A CA  1 
ATOM   245  C C   . ASP A 1 34  ? 154.509 143.136 121.226 1.00 54.90  ? 60  ASP A C   1 
ATOM   246  O O   . ASP A 1 34  ? 154.179 143.616 122.315 1.00 66.98  ? 60  ASP A O   1 
ATOM   247  C CB  . ASP A 1 34  ? 156.929 143.636 120.836 1.00 51.91  ? 60  ASP A CB  1 
ATOM   248  C CG  . ASP A 1 34  ? 157.981 144.042 119.823 1.00 63.74  ? 60  ASP A CG  1 
ATOM   249  O OD1 . ASP A 1 34  ? 158.132 145.257 119.575 1.00 65.57  ? 60  ASP A OD1 1 
ATOM   250  O OD2 . ASP A 1 34  ? 158.658 143.147 119.274 1.00 65.08  ? 60  ASP A OD2 1 
ATOM   251  N N   . PRO A 1 35  ? 154.013 141.976 120.799 1.00 47.35  ? 61  PRO A N   1 
ATOM   252  C CA  . PRO A 1 35  ? 152.987 141.254 121.565 1.00 54.23  ? 61  PRO A CA  1 
ATOM   253  C C   . PRO A 1 35  ? 153.508 140.251 122.588 1.00 55.15  ? 61  PRO A C   1 
ATOM   254  O O   . PRO A 1 35  ? 152.708 139.458 123.093 1.00 61.79  ? 61  PRO A O   1 
ATOM   255  C CB  . PRO A 1 35  ? 152.221 140.525 120.456 1.00 51.44  ? 61  PRO A CB  1 
ATOM   256  C CG  . PRO A 1 35  ? 153.272 140.210 119.457 1.00 54.79  ? 61  PRO A CG  1 
ATOM   257  C CD  . PRO A 1 35  ? 154.244 141.365 119.479 1.00 50.53  ? 61  PRO A CD  1 
ATOM   258  N N   . ALA A 1 36  ? 154.803 140.254 122.909 1.00 46.15  ? 62  ALA A N   1 
ATOM   259  C CA  . ALA A 1 36  ? 155.355 139.188 123.739 1.00 51.90  ? 62  ALA A CA  1 
ATOM   260  C C   . ALA A 1 36  ? 154.909 139.306 125.194 1.00 56.04  ? 62  ALA A C   1 
ATOM   261  O O   . ALA A 1 36  ? 154.526 138.304 125.814 1.00 66.64  ? 62  ALA A O   1 
ATOM   262  C CB  . ALA A 1 36  ? 156.879 139.190 123.641 1.00 54.77  ? 62  ALA A CB  1 
ATOM   263  N N   . SER A 1 37  ? 154.957 140.516 125.758 1.00 39.46  ? 63  SER A N   1 
ATOM   264  C CA  . SER A 1 37  ? 154.599 140.688 127.163 1.00 43.75  ? 63  SER A CA  1 
ATOM   265  C C   . SER A 1 37  ? 153.131 140.361 127.405 1.00 49.55  ? 63  SER A C   1 
ATOM   266  O O   . SER A 1 37  ? 152.785 139.721 128.408 1.00 52.51  ? 63  SER A O   1 
ATOM   267  C CB  . SER A 1 37  ? 154.913 142.114 127.610 1.00 45.02  ? 63  SER A CB  1 
ATOM   268  O OG  . SER A 1 37  ? 154.604 142.300 128.979 1.00 52.28  ? 63  SER A OG  1 
ATOM   269  N N   . LEU A 1 38  ? 152.256 140.790 126.493 1.00 46.80  ? 64  LEU A N   1 
ATOM   270  C CA  . LEU A 1 38  ? 150.842 140.460 126.614 1.00 42.18  ? 64  LEU A CA  1 
ATOM   271  C C   . LEU A 1 38  ? 150.623 138.957 126.523 1.00 46.17  ? 64  LEU A C   1 
ATOM   272  O O   . LEU A 1 38  ? 149.772 138.403 127.226 1.00 56.48  ? 64  LEU A O   1 
ATOM   273  C CB  . LEU A 1 38  ? 150.041 141.194 125.540 1.00 36.01  ? 64  LEU A CB  1 
ATOM   274  C CG  . LEU A 1 38  ? 148.523 141.039 125.595 1.00 46.19  ? 64  LEU A CG  1 
ATOM   275  C CD1 . LEU A 1 38  ? 148.002 141.373 126.980 1.00 52.17  ? 64  LEU A CD1 1 
ATOM   276  C CD2 . LEU A 1 38  ? 147.863 141.919 124.551 1.00 48.45  ? 64  LEU A CD2 1 
ATOM   277  N N   . ALA A 1 39  ? 151.392 138.277 125.670 1.00 40.69  ? 65  ALA A N   1 
ATOM   278  C CA  . ALA A 1 39  ? 151.281 136.826 125.565 1.00 41.21  ? 65  ALA A CA  1 
ATOM   279  C C   . ALA A 1 39  ? 151.698 136.137 126.859 1.00 45.46  ? 65  ALA A C   1 
ATOM   280  O O   . ALA A 1 39  ? 151.032 135.196 127.312 1.00 56.56  ? 65  ALA A O   1 
ATOM   281  C CB  . ALA A 1 39  ? 152.124 136.324 124.397 1.00 41.94  ? 65  ALA A CB  1 
ATOM   282  N N   . VAL A 1 40  ? 152.795 136.590 127.471 1.00 34.32  ? 66  VAL A N   1 
ATOM   283  C CA  . VAL A 1 40  ? 153.236 135.989 128.727 1.00 38.41  ? 66  VAL A CA  1 
ATOM   284  C C   . VAL A 1 40  ? 152.205 136.224 129.824 1.00 49.82  ? 66  VAL A C   1 
ATOM   285  O O   . VAL A 1 40  ? 151.895 135.318 130.614 1.00 55.60  ? 66  VAL A O   1 
ATOM   286  C CB  . VAL A 1 40  ? 154.619 136.534 129.123 1.00 37.63  ? 66  VAL A CB  1 
ATOM   287  C CG1 . VAL A 1 40  ? 155.046 135.974 130.466 1.00 43.68  ? 66  VAL A CG1 1 
ATOM   288  C CG2 . VAL A 1 40  ? 155.644 136.197 128.058 1.00 42.14  ? 66  VAL A CG2 1 
ATOM   289  N N   . PHE A 1 41  ? 151.647 137.437 129.887 1.00 44.28  ? 67  PHE A N   1 
ATOM   290  C CA  . PHE A 1 41  ? 150.624 137.715 130.888 1.00 36.30  ? 67  PHE A CA  1 
ATOM   291  C C   . PHE A 1 41  ? 149.380 136.871 130.653 1.00 43.98  ? 67  PHE A C   1 
ATOM   292  O O   . PHE A 1 41  ? 148.766 136.385 131.609 1.00 54.44  ? 67  PHE A O   1 
ATOM   293  C CB  . PHE A 1 41  ? 150.266 139.199 130.893 1.00 39.19  ? 67  PHE A CB  1 
ATOM   294  C CG  . PHE A 1 41  ? 149.107 139.536 131.785 1.00 40.50  ? 67  PHE A CG  1 
ATOM   295  C CD1 . PHE A 1 41  ? 149.252 139.533 133.159 1.00 42.03  ? 67  PHE A CD1 1 
ATOM   296  C CD2 . PHE A 1 41  ? 147.873 139.852 131.250 1.00 44.57  ? 67  PHE A CD2 1 
ATOM   297  C CE1 . PHE A 1 41  ? 148.189 139.838 133.981 1.00 41.78  ? 67  PHE A CE1 1 
ATOM   298  C CE2 . PHE A 1 41  ? 146.808 140.158 132.070 1.00 44.60  ? 67  PHE A CE2 1 
ATOM   299  C CZ  . PHE A 1 41  ? 146.968 140.151 133.436 1.00 40.01  ? 67  PHE A CZ  1 
ATOM   300  N N   . ARG A 1 42  ? 148.991 136.687 129.389 1.00 38.72  ? 68  ARG A N   1 
ATOM   301  C CA  . ARG A 1 42  ? 147.848 135.836 129.079 1.00 39.38  ? 68  ARG A CA  1 
ATOM   302  C C   . ARG A 1 42  ? 148.090 134.405 129.532 1.00 47.94  ? 68  ARG A C   1 
ATOM   303  O O   . ARG A 1 42  ? 147.205 133.774 130.121 1.00 57.38  ? 68  ARG A O   1 
ATOM   304  C CB  . ARG A 1 42  ? 147.560 135.878 127.580 1.00 39.60  ? 68  ARG A CB  1 
ATOM   305  C CG  . ARG A 1 42  ? 146.682 134.750 127.085 1.00 41.67  ? 68  ARG A CG  1 
ATOM   306  C CD  . ARG A 1 42  ? 146.769 134.600 125.578 1.00 50.07  ? 68  ARG A CD  1 
ATOM   307  N NE  . ARG A 1 42  ? 148.113 134.252 125.136 1.00 46.39  ? 68  ARG A NE  1 
ATOM   308  C CZ  . ARG A 1 42  ? 148.565 133.012 125.022 1.00 43.24  ? 68  ARG A CZ  1 
ATOM   309  N NH1 . ARG A 1 42  ? 147.807 131.971 125.320 1.00 47.48  ? 68  ARG A NH1 1 
ATOM   310  N NH2 . ARG A 1 42  ? 149.810 132.811 124.602 1.00 47.31  ? 68  ARG A NH2 1 
ATOM   311  N N   . PHE A 1 43  ? 149.291 133.880 129.275 1.00 46.12  ? 69  PHE A N   1 
ATOM   312  C CA  . PHE A 1 43  ? 149.594 132.512 129.681 1.00 41.96  ? 69  PHE A CA  1 
ATOM   313  C C   . PHE A 1 43  ? 149.536 132.363 131.195 1.00 45.36  ? 69  PHE A C   1 
ATOM   314  O O   . PHE A 1 43  ? 148.926 131.416 131.712 1.00 52.66  ? 69  PHE A O   1 
ATOM   315  C CB  . PHE A 1 43  ? 150.967 132.103 129.150 1.00 42.78  ? 69  PHE A CB  1 
ATOM   316  C CG  . PHE A 1 43  ? 151.359 130.697 129.495 1.00 48.33  ? 69  PHE A CG  1 
ATOM   317  C CD1 . PHE A 1 43  ? 150.855 129.628 128.777 1.00 54.11  ? 69  PHE A CD1 1 
ATOM   318  C CD2 . PHE A 1 43  ? 152.239 130.444 130.532 1.00 50.48  ? 69  PHE A CD2 1 
ATOM   319  C CE1 . PHE A 1 43  ? 151.217 128.334 129.091 1.00 55.83  ? 69  PHE A CE1 1 
ATOM   320  C CE2 . PHE A 1 43  ? 152.603 129.153 130.850 1.00 50.89  ? 69  PHE A CE2 1 
ATOM   321  C CZ  . PHE A 1 43  ? 152.093 128.096 130.129 1.00 53.02  ? 69  PHE A CZ  1 
ATOM   322  N N   . LEU A 1 44  ? 150.139 133.306 131.924 1.00 46.72  ? 70  LEU A N   1 
ATOM   323  C CA  . LEU A 1 44  ? 150.139 133.208 133.381 1.00 43.87  ? 70  LEU A CA  1 
ATOM   324  C C   . LEU A 1 44  ? 148.732 133.355 133.948 1.00 48.87  ? 70  LEU A C   1 
ATOM   325  O O   . LEU A 1 44  ? 148.346 132.616 134.863 1.00 58.04  ? 70  LEU A O   1 
ATOM   326  C CB  . LEU A 1 44  ? 151.077 134.256 133.977 1.00 47.93  ? 70  LEU A CB  1 
ATOM   327  C CG  . LEU A 1 44  ? 152.561 134.048 133.676 1.00 51.95  ? 70  LEU A CG  1 
ATOM   328  C CD1 . LEU A 1 44  ? 153.401 135.146 134.307 1.00 50.68  ? 70  LEU A CD1 1 
ATOM   329  C CD2 . LEU A 1 44  ? 153.014 132.679 134.155 1.00 50.84  ? 70  LEU A CD2 1 
ATOM   330  N N   . PHE A 1 45  ? 147.945 134.289 133.408 1.00 41.44  ? 71  PHE A N   1 
ATOM   331  C CA  . PHE A 1 45  ? 146.583 134.487 133.890 1.00 40.66  ? 71  PHE A CA  1 
ATOM   332  C C   . PHE A 1 45  ? 145.718 133.263 133.626 1.00 39.86  ? 71  PHE A C   1 
ATOM   333  O O   . PHE A 1 45  ? 144.940 132.848 134.494 1.00 50.35  ? 71  PHE A O   1 
ATOM   334  C CB  . PHE A 1 45  ? 145.980 135.728 133.236 1.00 45.64  ? 71  PHE A CB  1 
ATOM   335  C CG  . PHE A 1 45  ? 144.539 135.956 133.580 1.00 47.16  ? 71  PHE A CG  1 
ATOM   336  C CD1 . PHE A 1 45  ? 144.173 136.360 134.849 1.00 42.11  ? 71  PHE A CD1 1 
ATOM   337  C CD2 . PHE A 1 45  ? 143.552 135.779 132.629 1.00 46.22  ? 71  PHE A CD2 1 
ATOM   338  C CE1 . PHE A 1 45  ? 142.851 136.574 135.166 1.00 41.87  ? 71  PHE A CE1 1 
ATOM   339  C CE2 . PHE A 1 45  ? 142.227 135.994 132.940 1.00 42.22  ? 71  PHE A CE2 1 
ATOM   340  C CZ  . PHE A 1 45  ? 141.877 136.390 134.210 1.00 41.10  ? 71  PHE A CZ  1 
ATOM   341  N N   . GLY A 1 46  ? 145.841 132.668 132.438 1.00 39.09  ? 72  GLY A N   1 
ATOM   342  C CA  . GLY A 1 46  ? 145.078 131.469 132.148 1.00 43.61  ? 72  GLY A CA  1 
ATOM   343  C C   . GLY A 1 46  ? 145.467 130.304 133.036 1.00 44.13  ? 72  GLY A C   1 
ATOM   344  O O   . GLY A 1 46  ? 144.604 129.566 133.517 1.00 51.00  ? 72  GLY A O   1 
ATOM   345  N N   . PHE A 1 47  ? 146.769 130.131 133.280 1.00 43.42  ? 73  PHE A N   1 
ATOM   346  C CA  . PHE A 1 47  ? 147.211 129.060 134.168 1.00 44.29  ? 73  PHE A CA  1 
ATOM   347  C C   . PHE A 1 47  ? 146.673 129.262 135.579 1.00 48.59  ? 73  PHE A C   1 
ATOM   348  O O   . PHE A 1 47  ? 146.202 128.312 136.220 1.00 55.47  ? 73  PHE A O   1 
ATOM   349  C CB  . PHE A 1 47  ? 148.736 128.989 134.173 1.00 46.98  ? 73  PHE A CB  1 
ATOM   350  C CG  . PHE A 1 47  ? 149.291 127.850 134.974 1.00 50.61  ? 73  PHE A CG  1 
ATOM   351  C CD1 . PHE A 1 47  ? 149.201 126.551 134.508 1.00 50.63  ? 73  PHE A CD1 1 
ATOM   352  C CD2 . PHE A 1 47  ? 149.921 128.080 136.183 1.00 51.35  ? 73  PHE A CD2 1 
ATOM   353  C CE1 . PHE A 1 47  ? 149.716 125.501 135.240 1.00 53.32  ? 73  PHE A CE1 1 
ATOM   354  C CE2 . PHE A 1 47  ? 150.441 127.035 136.918 1.00 54.41  ? 73  PHE A CE2 1 
ATOM   355  C CZ  . PHE A 1 47  ? 150.337 125.744 136.447 1.00 56.14  ? 73  PHE A CZ  1 
ATOM   356  N N   . LEU A 1 48  ? 146.713 130.502 136.071 1.00 45.32  ? 74  LEU A N   1 
ATOM   357  C CA  . LEU A 1 48  ? 146.237 130.766 137.423 1.00 41.44  ? 74  LEU A CA  1 
ATOM   358  C C   . LEU A 1 48  ? 144.730 130.570 137.531 1.00 43.29  ? 74  LEU A C   1 
ATOM   359  O O   . LEU A 1 48  ? 144.243 130.046 138.537 1.00 47.81  ? 74  LEU A O   1 
ATOM   360  C CB  . LEU A 1 48  ? 146.640 132.174 137.854 1.00 43.15  ? 74  LEU A CB  1 
ATOM   361  C CG  . LEU A 1 48  ? 148.141 132.356 138.081 1.00 45.66  ? 74  LEU A CG  1 
ATOM   362  C CD1 . LEU A 1 48  ? 148.488 133.814 138.313 1.00 47.71  ? 74  LEU A CD1 1 
ATOM   363  C CD2 . LEU A 1 48  ? 148.611 131.502 139.245 1.00 46.76  ? 74  LEU A CD2 1 
ATOM   364  N N   . MET A 1 49  ? 143.973 130.959 136.502 1.00 44.50  ? 75  MET A N   1 
ATOM   365  C CA  . MET A 1 49  ? 142.531 130.728 136.548 1.00 40.23  ? 75  MET A CA  1 
ATOM   366  C C   . MET A 1 49  ? 142.193 129.244 136.450 1.00 47.84  ? 75  MET A C   1 
ATOM   367  O O   . MET A 1 49  ? 141.239 128.784 137.092 1.00 57.60  ? 75  MET A O   1 
ATOM   368  C CB  . MET A 1 49  ? 141.827 131.510 135.441 1.00 40.05  ? 75  MET A CB  1 
ATOM   369  C CG  . MET A 1 49  ? 141.928 133.019 135.587 1.00 48.74  ? 75  MET A CG  1 
ATOM   370  S SD  . MET A 1 49  ? 141.570 133.606 137.253 1.00 64.72  ? 75  MET A SD  1 
ATOM   371  C CE  . MET A 1 49  ? 139.877 133.064 137.460 1.00 50.76  ? 75  MET A CE  1 
ATOM   372  N N   . VAL A 1 50  ? 142.959 128.482 135.664 1.00 48.68  ? 76  VAL A N   1 
ATOM   373  C CA  . VAL A 1 50  ? 142.764 127.036 135.613 1.00 39.93  ? 76  VAL A CA  1 
ATOM   374  C C   . VAL A 1 50  ? 143.005 126.422 136.984 1.00 43.90  ? 76  VAL A C   1 
ATOM   375  O O   . VAL A 1 50  ? 142.249 125.552 137.433 1.00 47.65  ? 76  VAL A O   1 
ATOM   376  C CB  . VAL A 1 50  ? 143.675 126.406 134.542 1.00 40.28  ? 76  VAL A CB  1 
ATOM   377  C CG1 . VAL A 1 50  ? 143.744 124.902 134.717 1.00 38.06  ? 76  VAL A CG1 1 
ATOM   378  C CG2 . VAL A 1 50  ? 143.169 126.744 133.151 1.00 50.65  ? 76  VAL A CG2 1 
ATOM   379  N N   . LEU A 1 51  ? 144.057 126.865 137.675 1.00 48.67  ? 77  LEU A N   1 
ATOM   380  C CA  . LEU A 1 51  ? 144.317 126.340 139.013 1.00 42.92  ? 77  LEU A CA  1 
ATOM   381  C C   . LEU A 1 51  ? 143.286 126.824 140.028 1.00 45.07  ? 77  LEU A C   1 
ATOM   382  O O   . LEU A 1 51  ? 143.036 126.139 141.026 1.00 48.46  ? 77  LEU A O   1 
ATOM   383  C CB  . LEU A 1 51  ? 145.723 126.724 139.473 1.00 41.29  ? 77  LEU A CB  1 
ATOM   384  C CG  . LEU A 1 51  ? 146.883 125.933 138.873 1.00 44.80  ? 77  LEU A CG  1 
ATOM   385  C CD1 . LEU A 1 51  ? 148.191 126.336 139.532 1.00 48.78  ? 77  LEU A CD1 1 
ATOM   386  C CD2 . LEU A 1 51  ? 146.644 124.441 139.019 1.00 48.95  ? 77  LEU A CD2 1 
ATOM   387  N N   . ASP A 1 52  ? 142.682 127.988 139.797 1.00 47.91  ? 78  ASP A N   1 
ATOM   388  C CA  . ASP A 1 52  ? 141.774 128.589 140.766 1.00 48.82  ? 78  ASP A CA  1 
ATOM   389  C C   . ASP A 1 52  ? 140.339 128.098 140.645 1.00 44.36  ? 78  ASP A C   1 
ATOM   390  O O   . ASP A 1 52  ? 139.597 128.158 141.632 1.00 49.75  ? 78  ASP A O   1 
ATOM   391  C CB  . ASP A 1 52  ? 141.790 130.115 140.621 1.00 56.96  ? 78  ASP A CB  1 
ATOM   392  C CG  . ASP A 1 52  ? 141.082 130.819 141.760 1.00 60.22  ? 78  ASP A CG  1 
ATOM   393  O OD1 . ASP A 1 52  ? 140.984 130.229 142.855 1.00 55.42  ? 78  ASP A OD1 1 
ATOM   394  O OD2 . ASP A 1 52  ? 140.620 131.961 141.559 1.00 61.59  ? 78  ASP A OD2 1 
ATOM   395  N N   . ILE A 1 53  ? 139.923 127.629 139.466 1.00 45.11  ? 79  ILE A N   1 
ATOM   396  C CA  . ILE A 1 53  ? 138.539 127.173 139.300 1.00 39.78  ? 79  ILE A CA  1 
ATOM   397  C C   . ILE A 1 53  ? 138.172 126.048 140.265 1.00 44.80  ? 79  ILE A C   1 
ATOM   398  O O   . ILE A 1 53  ? 137.125 126.150 140.925 1.00 52.85  ? 79  ILE A O   1 
ATOM   399  C CB  . ILE A 1 53  ? 138.272 126.806 137.830 1.00 39.10  ? 79  ILE A CB  1 
ATOM   400  C CG1 . ILE A 1 53  ? 138.120 128.069 136.983 1.00 46.92  ? 79  ILE A CG1 1 
ATOM   401  C CG2 . ILE A 1 53  ? 137.031 125.942 137.710 1.00 42.67  ? 79  ILE A CG2 1 
ATOM   402  C CD1 . ILE A 1 53  ? 137.811 127.793 135.530 1.00 47.81  ? 79  ILE A CD1 1 
ATOM   403  N N   . PRO A 1 54  ? 138.960 124.976 140.411 1.00 43.08  ? 80  PRO A N   1 
ATOM   404  C CA  . PRO A 1 54  ? 138.552 123.891 141.312 1.00 39.49  ? 80  PRO A CA  1 
ATOM   405  C C   . PRO A 1 54  ? 138.808 124.153 142.788 1.00 47.12  ? 80  PRO A C   1 
ATOM   406  O O   . PRO A 1 54  ? 138.494 123.284 143.608 1.00 55.86  ? 80  PRO A O   1 
ATOM   407  C CB  . PRO A 1 54  ? 139.397 122.698 140.825 1.00 35.81  ? 80  PRO A CB  1 
ATOM   408  C CG  . PRO A 1 54  ? 139.999 123.122 139.531 1.00 40.45  ? 80  PRO A CG  1 
ATOM   409  C CD  . PRO A 1 54  ? 140.158 124.593 139.648 1.00 48.00  ? 80  PRO A CD  1 
ATOM   410  N N   . GLN A 1 55  ? 139.355 125.306 143.164 1.00 47.03  ? 81  GLN A N   1 
ATOM   411  C CA  . GLN A 1 55  ? 139.728 125.559 144.550 1.00 40.95  ? 81  GLN A CA  1 
ATOM   412  C C   . GLN A 1 55  ? 138.861 126.607 145.230 1.00 48.93  ? 81  GLN A C   1 
ATOM   413  O O   . GLN A 1 55  ? 138.287 126.337 146.289 1.00 55.23  ? 81  GLN A O   1 
ATOM   414  C CB  . GLN A 1 55  ? 141.202 125.980 144.629 1.00 49.95  ? 81  GLN A CB  1 
ATOM   415  C CG  . GLN A 1 55  ? 142.178 124.892 144.217 1.00 51.33  ? 81  GLN A CG  1 
ATOM   416  C CD  . GLN A 1 55  ? 143.621 125.323 144.357 1.00 55.46  ? 81  GLN A CD  1 
ATOM   417  O OE1 . GLN A 1 55  ? 143.908 126.440 144.785 1.00 57.61  ? 81  GLN A OE1 1 
ATOM   418  N NE2 . GLN A 1 55  ? 144.540 124.435 143.999 1.00 54.68  ? 81  GLN A NE2 1 
ATOM   419  N N   . GLU A 1 56  ? 138.743 127.801 144.653 1.00 58.31  ? 82  GLU A N   1 
ATOM   420  C CA  . GLU A 1 56  ? 137.990 128.878 145.283 1.00 57.24  ? 82  GLU A CA  1 
ATOM   421  C C   . GLU A 1 56  ? 136.601 129.070 144.696 1.00 56.23  ? 82  GLU A C   1 
ATOM   422  O O   . GLU A 1 56  ? 135.681 129.450 145.428 1.00 62.91  ? 82  GLU A O   1 
ATOM   423  C CB  . GLU A 1 56  ? 138.764 130.197 145.188 1.00 55.95  ? 82  GLU A CB  1 
ATOM   424  C CG  . GLU A 1 56  ? 138.161 131.333 145.997 1.00 59.04  ? 82  GLU A CG  1 
ATOM   425  C CD  . GLU A 1 56  ? 138.993 132.596 145.941 1.00 63.85  ? 82  GLU A CD  1 
ATOM   426  O OE1 . GLU A 1 56  ? 140.093 132.561 145.349 1.00 68.90  ? 82  GLU A OE1 1 
ATOM   427  O OE2 . GLU A 1 56  ? 138.548 133.627 146.487 1.00 60.84  ? 82  GLU A OE2 1 
ATOM   428  N N   . ARG A 1 57  ? 136.420 128.816 143.399 1.00 40.53  ? 83  ARG A N   1 
ATOM   429  C CA  . ARG A 1 57  ? 135.101 128.981 142.799 1.00 41.51  ? 83  ARG A CA  1 
ATOM   430  C C   . ARG A 1 57  ? 134.102 127.976 143.356 1.00 49.01  ? 83  ARG A C   1 
ATOM   431  O O   . ARG A 1 57  ? 132.902 128.265 143.414 1.00 50.87  ? 83  ARG A O   1 
ATOM   432  C CB  . ARG A 1 57  ? 135.192 128.856 141.280 1.00 45.25  ? 83  ARG A CB  1 
ATOM   433  C CG  . ARG A 1 57  ? 136.034 129.930 140.608 1.00 48.37  ? 83  ARG A CG  1 
ATOM   434  C CD  . ARG A 1 57  ? 135.266 131.231 140.422 1.00 43.19  ? 83  ARG A CD  1 
ATOM   435  N NE  . ARG A 1 57  ? 135.129 131.989 141.659 1.00 48.16  ? 83  ARG A NE  1 
ATOM   436  C CZ  . ARG A 1 57  ? 136.012 132.876 142.096 1.00 50.84  ? 83  ARG A CZ  1 
ATOM   437  N NH1 . ARG A 1 57  ? 137.120 133.138 141.422 1.00 49.28  ? 83  ARG A NH1 1 
ATOM   438  N NH2 . ARG A 1 57  ? 135.778 133.518 143.237 1.00 50.57  ? 83  ARG A NH2 1 
ATOM   439  N N   . GLY A 1 58  ? 134.569 126.801 143.764 1.00 52.67  ? 84  GLY A N   1 
ATOM   440  C CA  . GLY A 1 58  ? 133.710 125.844 144.431 1.00 52.44  ? 84  GLY A CA  1 
ATOM   441  C C   . GLY A 1 58  ? 133.287 124.680 143.562 1.00 51.93  ? 84  GLY A C   1 
ATOM   442  O O   . GLY A 1 58  ? 132.154 124.200 143.668 1.00 56.82  ? 84  GLY A O   1 
ATOM   443  N N   . LEU A 1 59  ? 134.186 124.215 142.694 1.00 39.92  ? 85  LEU A N   1 
ATOM   444  C CA  . LEU A 1 59  ? 133.866 123.058 141.867 1.00 43.27  ? 85  LEU A CA  1 
ATOM   445  C C   . LEU A 1 59  ? 133.842 121.775 142.688 1.00 43.90  ? 85  LEU A C   1 
ATOM   446  O O   . LEU A 1 59  ? 133.047 120.873 142.403 1.00 48.43  ? 85  LEU A O   1 
ATOM   447  C CB  . LEU A 1 59  ? 134.867 122.945 140.719 1.00 43.51  ? 85  LEU A CB  1 
ATOM   448  C CG  . LEU A 1 59  ? 134.574 121.886 139.657 1.00 43.67  ? 85  LEU A CG  1 
ATOM   449  C CD1 . LEU A 1 59  ? 133.191 122.085 139.070 1.00 40.93  ? 85  LEU A CD1 1 
ATOM   450  C CD2 . LEU A 1 59  ? 135.627 121.924 138.563 1.00 42.65  ? 85  LEU A CD2 1 
ATOM   451  N N   . SER A 1 60  ? 134.699 121.676 143.706 1.00 37.05  ? 86  SER A N   1 
ATOM   452  C CA  . SER A 1 60  ? 134.710 120.486 144.551 1.00 40.56  ? 86  SER A CA  1 
ATOM   453  C C   . SER A 1 60  ? 133.530 120.477 145.514 1.00 50.47  ? 86  SER A C   1 
ATOM   454  O O   . SER A 1 60  ? 132.980 119.413 145.821 1.00 55.08  ? 86  SER A O   1 
ATOM   455  C CB  . SER A 1 60  ? 136.027 120.406 145.319 1.00 42.23  ? 86  SER A CB  1 
ATOM   456  O OG  . SER A 1 60  ? 136.210 121.551 146.131 1.00 44.90  ? 86  SER A OG  1 
ATOM   457  N N   . SER A 1 61  ? 133.128 121.649 145.998 1.00 53.25  ? 87  SER A N   1 
ATOM   458  C CA  . SER A 1 61  ? 132.046 121.781 146.963 1.00 48.79  ? 87  SER A CA  1 
ATOM   459  C C   . SER A 1 61  ? 130.705 122.069 146.305 1.00 44.67  ? 87  SER A C   1 
ATOM   460  O O   . SER A 1 61  ? 129.759 122.459 146.994 1.00 56.64  ? 87  SER A O   1 
ATOM   461  C CB  . SER A 1 61  ? 132.376 122.879 147.975 1.00 51.92  ? 87  SER A CB  1 
ATOM   462  O OG  . SER A 1 61  ? 131.318 123.058 148.900 1.00 58.64  ? 87  SER A OG  1 
ATOM   463  N N   . LEU A 1 62  ? 130.602 121.888 144.988 1.00 38.26  ? 88  LEU A N   1 
ATOM   464  C CA  . LEU A 1 62  ? 129.377 122.237 144.282 1.00 42.62  ? 88  LEU A CA  1 
ATOM   465  C C   . LEU A 1 62  ? 128.238 121.269 144.571 1.00 42.03  ? 88  LEU A C   1 
ATOM   466  O O   . LEU A 1 62  ? 127.072 121.650 144.430 1.00 51.52  ? 88  LEU A O   1 
ATOM   467  C CB  . LEU A 1 62  ? 129.640 122.293 142.776 1.00 46.14  ? 88  LEU A CB  1 
ATOM   468  C CG  . LEU A 1 62  ? 128.639 123.078 141.930 1.00 44.07  ? 88  LEU A CG  1 
ATOM   469  C CD1 . LEU A 1 62  ? 128.695 124.551 142.288 1.00 44.45  ? 88  LEU A CD1 1 
ATOM   470  C CD2 . LEU A 1 62  ? 128.909 122.878 140.452 1.00 43.85  ? 88  LEU A CD2 1 
ATOM   471  N N   . ASP A 1 63  ? 128.540 120.038 144.981 1.00 51.49  ? 89  ASP A N   1 
ATOM   472  C CA  . ASP A 1 63  ? 127.496 119.054 145.235 1.00 55.41  ? 89  ASP A CA  1 
ATOM   473  C C   . ASP A 1 63  ? 126.844 119.218 146.599 1.00 56.64  ? 89  ASP A C   1 
ATOM   474  O O   . ASP A 1 63  ? 125.850 118.538 146.877 1.00 61.08  ? 89  ASP A O   1 
ATOM   475  C CB  . ASP A 1 63  ? 128.060 117.638 145.107 1.00 59.53  ? 89  ASP A CB  1 
ATOM   476  C CG  . ASP A 1 63  ? 129.134 117.345 146.132 1.00 60.80  ? 89  ASP A CG  1 
ATOM   477  O OD1 . ASP A 1 63  ? 129.851 118.286 146.530 1.00 60.81  ? 89  ASP A OD1 1 
ATOM   478  O OD2 . ASP A 1 63  ? 129.264 116.172 146.539 1.00 61.09  ? 89  ASP A OD2 1 
ATOM   479  N N   . ARG A 1 64  ? 127.373 120.094 147.452 1.00 55.59  ? 90  ARG A N   1 
ATOM   480  C CA  . ARG A 1 64  ? 126.775 120.383 148.749 1.00 52.39  ? 90  ARG A CA  1 
ATOM   481  C C   . ARG A 1 64  ? 126.364 121.842 148.872 1.00 54.04  ? 90  ARG A C   1 
ATOM   482  O O   . ARG A 1 64  ? 126.104 122.313 149.985 1.00 60.77  ? 90  ARG A O   1 
ATOM   483  C CB  . ARG A 1 64  ? 127.736 120.006 149.879 1.00 54.09  ? 90  ARG A CB  1 
ATOM   484  C CG  . ARG A 1 64  ? 129.092 120.681 149.796 1.00 59.43  ? 90  ARG A CG  1 
ATOM   485  C CD  . ARG A 1 64  ? 130.043 120.120 150.840 1.00 63.23  ? 90  ARG A CD  1 
ATOM   486  N NE  . ARG A 1 64  ? 130.210 118.678 150.699 1.00 67.01  ? 90  ARG A NE  1 
ATOM   487  C CZ  . ARG A 1 64  ? 130.968 117.930 151.489 1.00 66.02  ? 90  ARG A CZ  1 
ATOM   488  N NH1 . ARG A 1 64  ? 131.651 118.457 152.492 1.00 61.76  ? 90  ARG A NH1 1 
ATOM   489  N NH2 . ARG A 1 64  ? 131.044 116.621 151.266 1.00 60.59  ? 90  ARG A NH2 1 
ATOM   490  N N   . LYS A 1 65  ? 126.300 122.564 147.759 1.00 48.86  ? 91  LYS A N   1 
ATOM   491  C CA  . LYS A 1 65  ? 125.864 123.953 147.721 1.00 45.33  ? 91  LYS A CA  1 
ATOM   492  C C   . LYS A 1 65  ? 124.575 124.147 146.943 1.00 48.18  ? 91  LYS A C   1 
ATOM   493  O O   . LYS A 1 65  ? 123.718 124.927 147.362 1.00 56.66  ? 91  LYS A O   1 
ATOM   494  C CB  . LYS A 1 65  ? 126.961 124.832 147.111 1.00 46.80  ? 91  LYS A CB  1 
ATOM   495  C CG  . LYS A 1 65  ? 126.692 126.321 147.202 1.00 58.28  ? 91  LYS A CG  1 
ATOM   496  C CD  . LYS A 1 65  ? 127.878 127.123 146.695 1.00 59.19  ? 91  LYS A CD  1 
ATOM   497  C CE  . LYS A 1 65  ? 127.630 128.616 146.818 1.00 58.55  ? 91  LYS A CE  1 
ATOM   498  N NZ  . LYS A 1 65  ? 127.394 129.028 148.230 1.00 58.44  ? 91  LYS A NZ  1 
ATOM   499  N N   . TYR A 1 66  ? 124.416 123.453 145.818 1.00 41.41  ? 92  TYR A N   1 
ATOM   500  C CA  . TYR A 1 66  ? 123.211 123.514 145.000 1.00 41.82  ? 92  TYR A CA  1 
ATOM   501  C C   . TYR A 1 66  ? 122.487 122.172 144.988 1.00 48.42  ? 92  TYR A C   1 
ATOM   502  O O   . TYR A 1 66  ? 121.971 121.734 143.959 1.00 57.09  ? 92  TYR A O   1 
ATOM   503  C CB  . TYR A 1 66  ? 123.541 123.953 143.577 1.00 42.76  ? 92  TYR A CB  1 
ATOM   504  C CG  . TYR A 1 66  ? 124.141 125.334 143.490 1.00 46.08  ? 92  TYR A CG  1 
ATOM   505  C CD1 . TYR A 1 66  ? 123.334 126.459 143.431 1.00 50.99  ? 92  TYR A CD1 1 
ATOM   506  C CD2 . TYR A 1 66  ? 125.513 125.514 143.469 1.00 47.87  ? 92  TYR A CD2 1 
ATOM   507  C CE1 . TYR A 1 66  ? 123.879 127.724 143.355 1.00 50.03  ? 92  TYR A CE1 1 
ATOM   508  C CE2 . TYR A 1 66  ? 126.067 126.773 143.393 1.00 50.47  ? 92  TYR A CE2 1 
ATOM   509  C CZ  . TYR A 1 66  ? 125.247 127.875 143.336 1.00 50.87  ? 92  TYR A CZ  1 
ATOM   510  O OH  . TYR A 1 66  ? 125.797 129.133 143.259 1.00 53.65  ? 92  TYR A OH  1 
ATOM   511  N N   . LEU A 1 67  ? 122.447 121.506 146.138 1.00 52.67  ? 93  LEU A N   1 
ATOM   512  C CA  . LEU A 1 67  ? 121.819 120.197 146.227 1.00 54.05  ? 93  LEU A CA  1 
ATOM   513  C C   . LEU A 1 67  ? 120.318 120.304 145.990 1.00 55.95  ? 93  LEU A C   1 
ATOM   514  O O   . LEU A 1 67  ? 119.648 121.189 146.530 1.00 61.32  ? 93  LEU A O   1 
ATOM   515  C CB  . LEU A 1 67  ? 122.095 119.572 147.593 1.00 54.60  ? 93  LEU A CB  1 
ATOM   516  C CG  . LEU A 1 67  ? 121.528 118.176 147.845 1.00 58.03  ? 93  LEU A CG  1 
ATOM   517  C CD1 . LEU A 1 67  ? 122.025 117.198 146.793 1.00 58.61  ? 93  LEU A CD1 1 
ATOM   518  C CD2 . LEU A 1 67  ? 121.899 117.700 149.239 1.00 56.26  ? 93  LEU A CD2 1 
ATOM   519  N N   . ASP A 1 68  ? 119.793 119.394 145.176 1.00 59.53  ? 94  ASP A N   1 
ATOM   520  C CA  . ASP A 1 68  ? 118.379 119.421 144.833 1.00 61.26  ? 94  ASP A CA  1 
ATOM   521  C C   . ASP A 1 68  ? 117.529 118.976 146.014 1.00 64.14  ? 94  ASP A C   1 
ATOM   522  O O   . ASP A 1 68  ? 117.889 118.055 146.752 1.00 65.66  ? 94  ASP A O   1 
ATOM   523  C CB  . ASP A 1 68  ? 118.109 118.527 143.624 1.00 64.99  ? 94  ASP A CB  1 
ATOM   524  C CG  . ASP A 1 68  ? 118.750 119.054 142.357 1.00 71.25  ? 94  ASP A CG  1 
ATOM   525  O OD1 . ASP A 1 68  ? 118.863 120.289 142.218 1.00 72.85  ? 94  ASP A OD1 1 
ATOM   526  O OD2 . ASP A 1 68  ? 119.141 118.233 141.500 1.00 72.27  ? 94  ASP A OD2 1 
ATOM   527  N N   . GLY A 1 69  ? 116.389 119.641 146.190 1.00 64.14  ? 95  GLY A N   1 
ATOM   528  C CA  . GLY A 1 69  ? 115.488 119.364 147.282 1.00 66.31  ? 95  GLY A CA  1 
ATOM   529  C C   . GLY A 1 69  ? 115.768 120.143 148.548 1.00 62.32  ? 95  GLY A C   1 
ATOM   530  O O   . GLY A 1 69  ? 114.905 120.197 149.430 1.00 63.58  ? 95  GLY A O   1 
ATOM   531  N N   . LEU A 1 70  ? 116.946 120.748 148.662 1.00 55.37  ? 96  LEU A N   1 
ATOM   532  C CA  . LEU A 1 70  ? 117.290 121.538 149.833 1.00 56.32  ? 96  LEU A CA  1 
ATOM   533  C C   . LEU A 1 70  ? 116.730 122.946 149.683 1.00 60.55  ? 96  LEU A C   1 
ATOM   534  O O   . LEU A 1 70  ? 116.876 123.572 148.629 1.00 62.29  ? 96  LEU A O   1 
ATOM   535  C CB  . LEU A 1 70  ? 118.806 121.579 150.017 1.00 59.67  ? 96  LEU A CB  1 
ATOM   536  C CG  . LEU A 1 70  ? 119.342 122.127 151.339 1.00 63.98  ? 96  LEU A CG  1 
ATOM   537  C CD1 . LEU A 1 70  ? 118.849 121.289 152.508 1.00 59.42  ? 96  LEU A CD1 1 
ATOM   538  C CD2 . LEU A 1 70  ? 120.862 122.176 151.313 1.00 62.43  ? 96  LEU A CD2 1 
ATOM   539  N N   . ASP A 1 71  ? 116.087 123.441 150.737 1.00 60.20  ? 97  ASP A N   1 
ATOM   540  C CA  . ASP A 1 71  ? 115.485 124.772 150.740 1.00 56.40  ? 97  ASP A CA  1 
ATOM   541  C C   . ASP A 1 71  ? 116.473 125.738 151.386 1.00 56.25  ? 97  ASP A C   1 
ATOM   542  O O   . ASP A 1 71  ? 116.620 125.769 152.610 1.00 57.00  ? 97  ASP A O   1 
ATOM   543  C CB  . ASP A 1 71  ? 114.146 124.757 151.468 1.00 55.41  ? 97  ASP A CB  1 
ATOM   544  C CG  . ASP A 1 71  ? 114.178 123.921 152.731 1.00 61.37  ? 97  ASP A CG  1 
ATOM   545  O OD1 . ASP A 1 71  ? 115.241 123.342 153.035 1.00 62.60  ? 97  ASP A OD1 1 
ATOM   546  O OD2 . ASP A 1 71  ? 113.138 123.839 153.418 1.00 64.06  ? 97  ASP A OD2 1 
ATOM   547  N N   . VAL A 1 72  ? 117.153 126.525 150.555 1.00 49.14  ? 98  VAL A N   1 
ATOM   548  C CA  . VAL A 1 72  ? 118.145 127.484 151.014 1.00 48.29  ? 98  VAL A CA  1 
ATOM   549  C C   . VAL A 1 72  ? 117.728 128.872 150.549 1.00 52.90  ? 98  VAL A C   1 
ATOM   550  O O   . VAL A 1 72  ? 116.982 129.034 149.581 1.00 57.90  ? 98  VAL A O   1 
ATOM   551  C CB  . VAL A 1 72  ? 119.563 127.145 150.506 1.00 53.83  ? 98  VAL A CB  1 
ATOM   552  C CG1 . VAL A 1 72  ? 120.621 127.770 151.403 1.00 55.86  ? 98  VAL A CG1 1 
ATOM   553  C CG2 . VAL A 1 72  ? 119.754 125.644 150.418 1.00 55.72  ? 98  VAL A CG2 1 
ATOM   554  N N   . CYS A 1 73  ? 118.222 129.882 151.259 1.00 55.41  ? 99  CYS A N   1 
ATOM   555  C CA  . CYS A 1 73  ? 117.964 131.277 150.931 1.00 51.26  ? 99  CYS A CA  1 
ATOM   556  C C   . CYS A 1 73  ? 119.160 131.838 150.173 1.00 56.03  ? 99  CYS A C   1 
ATOM   557  O O   . CYS A 1 73  ? 120.263 131.922 150.723 1.00 62.26  ? 99  CYS A O   1 
ATOM   558  C CB  . CYS A 1 73  ? 117.696 132.094 152.194 1.00 45.28  ? 99  CYS A CB  1 
ATOM   559  S SG  . CYS A 1 73  ? 116.349 131.472 153.221 1.00 74.93  ? 99  CYS A SG  1 
ATOM   560  N N   . ARG A 1 74  ? 118.941 132.217 148.920 1.00 49.86  ? 100 ARG A N   1 
ATOM   561  C CA  . ARG A 1 74  ? 119.996 132.760 148.081 1.00 48.35  ? 100 ARG A CA  1 
ATOM   562  C C   . ARG A 1 74  ? 120.061 134.275 148.226 1.00 49.90  ? 100 ARG A C   1 
ATOM   563  O O   . ARG A 1 74  ? 119.099 134.928 148.638 1.00 52.41  ? 100 ARG A O   1 
ATOM   564  C CB  . ARG A 1 74  ? 119.765 132.392 146.615 1.00 54.64  ? 100 ARG A CB  1 
ATOM   565  C CG  . ARG A 1 74  ? 119.400 130.939 146.376 1.00 53.78  ? 100 ARG A CG  1 
ATOM   566  C CD  . ARG A 1 74  ? 120.559 130.007 146.668 1.00 50.66  ? 100 ARG A CD  1 
ATOM   567  N NE  . ARG A 1 74  ? 120.227 128.628 146.332 1.00 48.19  ? 100 ARG A NE  1 
ATOM   568  C CZ  . ARG A 1 74  ? 121.048 127.600 146.486 1.00 48.98  ? 100 ARG A CZ  1 
ATOM   569  N NH1 . ARG A 1 74  ? 122.269 127.758 146.969 1.00 51.62  ? 100 ARG A NH1 1 
ATOM   570  N NH2 . ARG A 1 74  ? 120.633 126.383 146.148 1.00 48.93  ? 100 ARG A NH2 1 
ATOM   571  N N   . PHE A 1 75  ? 121.218 134.835 147.877 1.00 43.72  ? 101 PHE A N   1 
ATOM   572  C CA  . PHE A 1 75  ? 121.446 136.279 147.921 1.00 42.60  ? 101 PHE A CA  1 
ATOM   573  C C   . PHE A 1 75  ? 122.014 136.737 146.586 1.00 43.20  ? 101 PHE A C   1 
ATOM   574  O O   . PHE A 1 75  ? 123.202 137.073 146.484 1.00 47.22  ? 101 PHE A O   1 
ATOM   575  C CB  . PHE A 1 75  ? 122.378 136.656 149.073 1.00 41.72  ? 101 PHE A CB  1 
ATOM   576  C CG  . PHE A 1 75  ? 121.883 136.223 150.420 1.00 40.05  ? 101 PHE A CG  1 
ATOM   577  C CD1 . PHE A 1 75  ? 120.858 136.905 151.048 1.00 40.25  ? 101 PHE A CD1 1 
ATOM   578  C CD2 . PHE A 1 75  ? 122.442 135.134 151.061 1.00 43.72  ? 101 PHE A CD2 1 
ATOM   579  C CE1 . PHE A 1 75  ? 120.400 136.507 152.286 1.00 38.39  ? 101 PHE A CE1 1 
ATOM   580  C CE2 . PHE A 1 75  ? 121.988 134.735 152.297 1.00 41.75  ? 101 PHE A CE2 1 
ATOM   581  C CZ  . PHE A 1 75  ? 120.966 135.422 152.910 1.00 40.15  ? 101 PHE A CZ  1 
ATOM   582  N N   . PRO A 1 76  ? 121.195 136.768 145.540 1.00 38.52  ? 102 PRO A N   1 
ATOM   583  C CA  . PRO A 1 76  ? 121.645 137.290 144.251 1.00 37.23  ? 102 PRO A CA  1 
ATOM   584  C C   . PRO A 1 76  ? 121.440 138.798 144.161 1.00 42.19  ? 102 PRO A C   1 
ATOM   585  O O   . PRO A 1 76  ? 120.697 139.402 144.936 1.00 47.07  ? 102 PRO A O   1 
ATOM   586  C CB  . PRO A 1 76  ? 120.751 136.550 143.247 1.00 36.42  ? 102 PRO A CB  1 
ATOM   587  C CG  . PRO A 1 76  ? 119.542 136.105 144.038 1.00 39.90  ? 102 PRO A CG  1 
ATOM   588  C CD  . PRO A 1 76  ? 119.776 136.385 145.498 1.00 40.40  ? 102 PRO A CD  1 
ATOM   589  N N   . LEU A 1 77  ? 122.132 139.402 143.193 1.00 40.02  ? 103 LEU A N   1 
ATOM   590  C CA  . LEU A 1 77  ? 121.979 140.836 142.971 1.00 37.07  ? 103 LEU A CA  1 
ATOM   591  C C   . LEU A 1 77  ? 120.561 141.166 142.527 1.00 43.48  ? 103 LEU A C   1 
ATOM   592  O O   . LEU A 1 77  ? 119.953 142.121 143.023 1.00 52.24  ? 103 LEU A O   1 
ATOM   593  C CB  . LEU A 1 77  ? 122.996 141.319 141.936 1.00 40.36  ? 103 LEU A CB  1 
ATOM   594  C CG  . LEU A 1 77  ? 123.589 142.724 142.080 1.00 44.89  ? 103 LEU A CG  1 
ATOM   595  C CD1 . LEU A 1 77  ? 124.690 142.932 141.057 1.00 43.06  ? 103 LEU A CD1 1 
ATOM   596  C CD2 . LEU A 1 77  ? 122.534 143.809 141.941 1.00 45.49  ? 103 LEU A CD2 1 
ATOM   597  N N   . LEU A 1 78  ? 120.018 140.385 141.601 1.00 53.02  ? 104 LEU A N   1 
ATOM   598  C CA  . LEU A 1 78  ? 118.645 140.526 141.148 1.00 51.26  ? 104 LEU A CA  1 
ATOM   599  C C   . LEU A 1 78  ? 117.853 139.301 141.579 1.00 55.40  ? 104 LEU A C   1 
ATOM   600  O O   . LEU A 1 78  ? 118.350 138.173 141.506 1.00 65.49  ? 104 LEU A O   1 
ATOM   601  C CB  . LEU A 1 78  ? 118.571 140.690 139.627 1.00 55.28  ? 104 LEU A CB  1 
ATOM   602  C CG  . LEU A 1 78  ? 119.338 141.852 138.992 1.00 60.70  ? 104 LEU A CG  1 
ATOM   603  C CD1 . LEU A 1 78  ? 120.767 141.453 138.647 1.00 59.91  ? 104 LEU A CD1 1 
ATOM   604  C CD2 . LEU A 1 78  ? 118.609 142.364 137.758 1.00 57.76  ? 104 LEU A CD2 1 
ATOM   605  N N   . ASP A 1 79  ? 116.621 139.527 142.035 1.00 57.23  ? 105 ASP A N   1 
ATOM   606  C CA  . ASP A 1 79  ? 115.790 138.423 142.495 1.00 63.59  ? 105 ASP A CA  1 
ATOM   607  C C   . ASP A 1 79  ? 115.394 137.483 141.364 1.00 62.04  ? 105 ASP A C   1 
ATOM   608  O O   . ASP A 1 79  ? 115.009 136.340 141.630 1.00 59.43  ? 105 ASP A O   1 
ATOM   609  C CB  . ASP A 1 79  ? 114.538 138.963 143.187 1.00 67.30  ? 105 ASP A CB  1 
ATOM   610  C CG  . ASP A 1 79  ? 114.866 139.934 144.304 1.00 69.47  ? 105 ASP A CG  1 
ATOM   611  O OD1 . ASP A 1 79  ? 115.993 139.867 144.837 1.00 67.70  ? 105 ASP A OD1 1 
ATOM   612  O OD2 . ASP A 1 79  ? 113.997 140.763 144.648 1.00 65.92  ? 105 ASP A OD2 1 
ATOM   613  N N   . ALA A 1 80  ? 115.481 137.936 140.112 1.00 57.36  ? 106 ALA A N   1 
ATOM   614  C CA  . ALA A 1 80  ? 115.096 137.087 138.991 1.00 54.29  ? 106 ALA A CA  1 
ATOM   615  C C   . ALA A 1 80  ? 116.092 135.958 138.764 1.00 57.99  ? 106 ALA A C   1 
ATOM   616  O O   . ALA A 1 80  ? 115.709 134.887 138.280 1.00 62.65  ? 106 ALA A O   1 
ATOM   617  C CB  . ALA A 1 80  ? 114.949 137.925 137.722 1.00 56.39  ? 106 ALA A CB  1 
ATOM   618  N N   . LEU A 1 81  ? 117.363 136.172 139.095 1.00 56.38  ? 107 LEU A N   1 
ATOM   619  C CA  . LEU A 1 81  ? 118.370 135.141 138.886 1.00 57.14  ? 107 LEU A CA  1 
ATOM   620  C C   . LEU A 1 81  ? 118.150 133.977 139.840 1.00 55.52  ? 107 LEU A C   1 
ATOM   621  O O   . LEU A 1 81  ? 118.056 134.164 141.057 1.00 60.08  ? 107 LEU A O   1 
ATOM   622  C CB  . LEU A 1 81  ? 119.772 135.716 139.074 1.00 51.58  ? 107 LEU A CB  1 
ATOM   623  C CG  . LEU A 1 81  ? 120.351 136.511 137.906 1.00 55.24  ? 107 LEU A CG  1 
ATOM   624  C CD1 . LEU A 1 81  ? 121.766 136.960 138.219 1.00 54.10  ? 107 LEU A CD1 1 
ATOM   625  C CD2 . LEU A 1 81  ? 120.320 135.683 136.633 1.00 54.64  ? 107 LEU A CD2 1 
ATOM   626  N N   . ARG A 1 82  ? 118.073 132.773 139.287 1.00 44.58  ? 108 ARG A N   1 
ATOM   627  C CA  . ARG A 1 82  ? 117.933 131.561 140.072 1.00 48.81  ? 108 ARG A CA  1 
ATOM   628  C C   . ARG A 1 82  ? 118.917 130.515 139.574 1.00 52.24  ? 108 ARG A C   1 
ATOM   629  O O   . ARG A 1 82  ? 119.195 130.440 138.374 1.00 58.20  ? 108 ARG A O   1 
ATOM   630  C CB  . ARG A 1 82  ? 116.506 131.002 139.991 1.00 54.68  ? 108 ARG A CB  1 
ATOM   631  C CG  . ARG A 1 82  ? 115.438 131.931 140.541 1.00 54.89  ? 108 ARG A CG  1 
ATOM   632  C CD  . ARG A 1 82  ? 114.068 131.274 140.513 1.00 54.05  ? 108 ARG A CD  1 
ATOM   633  N NE  . ARG A 1 82  ? 113.684 130.865 139.167 1.00 62.46  ? 108 ARG A NE  1 
ATOM   634  C CZ  . ARG A 1 82  ? 112.999 131.622 138.321 1.00 63.52  ? 108 ARG A CZ  1 
ATOM   635  N NH1 . ARG A 1 82  ? 112.598 132.839 138.650 1.00 57.63  ? 108 ARG A NH1 1 
ATOM   636  N NH2 . ARG A 1 82  ? 112.707 131.144 137.114 1.00 61.25  ? 108 ARG A NH2 1 
ATOM   637  N N   . PRO A 1 83  ? 119.462 129.700 140.472 1.00 41.75  ? 109 PRO A N   1 
ATOM   638  C CA  . PRO A 1 83  ? 120.397 128.659 140.040 1.00 36.15  ? 109 PRO A CA  1 
ATOM   639  C C   . PRO A 1 83  ? 119.695 127.553 139.268 1.00 45.58  ? 109 PRO A C   1 
ATOM   640  O O   . PRO A 1 83  ? 118.528 127.233 139.507 1.00 55.92  ? 109 PRO A O   1 
ATOM   641  C CB  . PRO A 1 83  ? 120.972 128.129 141.359 1.00 39.93  ? 109 PRO A CB  1 
ATOM   642  C CG  . PRO A 1 83  ? 120.673 129.186 142.370 1.00 47.47  ? 109 PRO A CG  1 
ATOM   643  C CD  . PRO A 1 83  ? 119.381 129.794 141.937 1.00 45.54  ? 109 PRO A CD  1 
ATOM   644  N N   . LEU A 1 84  ? 120.429 126.972 138.328 1.00 38.28  ? 110 LEU A N   1 
ATOM   645  C CA  . LEU A 1 84  ? 119.972 125.807 137.589 1.00 34.92  ? 110 LEU A CA  1 
ATOM   646  C C   . LEU A 1 84  ? 120.178 124.555 138.431 1.00 44.78  ? 110 LEU A C   1 
ATOM   647  O O   . LEU A 1 84  ? 120.809 124.599 139.488 1.00 58.90  ? 110 LEU A O   1 
ATOM   648  C CB  . LEU A 1 84  ? 120.725 125.719 136.264 1.00 34.36  ? 110 LEU A CB  1 
ATOM   649  C CG  . LEU A 1 84  ? 120.588 126.914 135.321 1.00 39.52  ? 110 LEU A CG  1 
ATOM   650  C CD1 . LEU A 1 84  ? 121.392 126.686 134.055 1.00 40.97  ? 110 LEU A CD1 1 
ATOM   651  C CD2 . LEU A 1 84  ? 119.126 127.174 134.993 1.00 45.88  ? 110 LEU A CD2 1 
ATOM   652  N N   . PRO A 1 85  ? 119.642 123.413 137.999 1.00 28.05  ? 111 PRO A N   1 
ATOM   653  C CA  . PRO A 1 85  ? 119.963 122.150 138.674 1.00 27.86  ? 111 PRO A CA  1 
ATOM   654  C C   . PRO A 1 85  ? 121.459 121.870 138.660 1.00 43.07  ? 111 PRO A C   1 
ATOM   655  O O   . PRO A 1 85  ? 122.248 122.520 137.970 1.00 58.95  ? 111 PRO A O   1 
ATOM   656  C CB  . PRO A 1 85  ? 119.186 121.112 137.863 1.00 33.22  ? 111 PRO A CB  1 
ATOM   657  C CG  . PRO A 1 85  ? 118.023 121.866 137.340 1.00 33.08  ? 111 PRO A CG  1 
ATOM   658  C CD  . PRO A 1 85  ? 118.521 123.253 137.056 1.00 29.27  ? 111 PRO A CD  1 
ATOM   659  N N   . LEU A 1 86  ? 121.846 120.866 139.450 1.00 35.53  ? 112 LEU A N   1 
ATOM   660  C CA  . LEU A 1 86  ? 123.262 120.611 139.701 1.00 40.85  ? 112 LEU A CA  1 
ATOM   661  C C   . LEU A 1 86  ? 124.005 120.227 138.426 1.00 51.12  ? 112 LEU A C   1 
ATOM   662  O O   . LEU A 1 86  ? 125.140 120.671 138.204 1.00 63.34  ? 112 LEU A O   1 
ATOM   663  C CB  . LEU A 1 86  ? 123.407 119.521 140.761 1.00 38.60  ? 112 LEU A CB  1 
ATOM   664  C CG  . LEU A 1 86  ? 124.771 119.417 141.437 1.00 43.76  ? 112 LEU A CG  1 
ATOM   665  C CD1 . LEU A 1 86  ? 125.155 120.754 142.035 1.00 48.13  ? 112 LEU A CD1 1 
ATOM   666  C CD2 . LEU A 1 86  ? 124.754 118.339 142.504 1.00 45.16  ? 112 LEU A CD2 1 
ATOM   667  N N   . ASP A 1 87  ? 123.388 119.398 137.581 1.00 42.61  ? 113 ASP A N   1 
ATOM   668  C CA  . ASP A 1 87  ? 124.066 118.926 136.378 1.00 42.20  ? 113 ASP A CA  1 
ATOM   669  C C   . ASP A 1 87  ? 124.389 120.076 135.432 1.00 49.03  ? 113 ASP A C   1 
ATOM   670  O O   . ASP A 1 87  ? 125.483 120.129 134.852 1.00 59.07  ? 113 ASP A O   1 
ATOM   671  C CB  . ASP A 1 87  ? 123.207 117.876 135.678 1.00 46.01  ? 113 ASP A CB  1 
ATOM   672  C CG  . ASP A 1 87  ? 122.769 116.770 136.611 1.00 52.77  ? 113 ASP A CG  1 
ATOM   673  O OD1 . ASP A 1 87  ? 123.468 116.532 137.617 1.00 54.66  ? 113 ASP A OD1 1 
ATOM   674  O OD2 . ASP A 1 87  ? 121.727 116.140 136.343 1.00 55.44  ? 113 ASP A OD2 1 
ATOM   675  N N   . TRP A 1 88  ? 123.457 121.014 135.268 1.00 30.41  ? 114 TRP A N   1 
ATOM   676  C CA  . TRP A 1 88  ? 123.716 122.144 134.388 1.00 34.49  ? 114 TRP A CA  1 
ATOM   677  C C   . TRP A 1 88  ? 124.743 123.095 134.989 1.00 40.64  ? 114 TRP A C   1 
ATOM   678  O O   . TRP A 1 88  ? 125.499 123.735 134.249 1.00 53.70  ? 114 TRP A O   1 
ATOM   679  C CB  . TRP A 1 88  ? 122.408 122.862 134.076 1.00 36.33  ? 114 TRP A CB  1 
ATOM   680  C CG  . TRP A 1 88  ? 121.384 121.939 133.498 1.00 37.29  ? 114 TRP A CG  1 
ATOM   681  C CD1 . TRP A 1 88  ? 120.401 121.282 134.175 1.00 43.25  ? 114 TRP A CD1 1 
ATOM   682  C CD2 . TRP A 1 88  ? 121.254 121.552 132.126 1.00 42.52  ? 114 TRP A CD2 1 
ATOM   683  N NE1 . TRP A 1 88  ? 119.660 120.516 133.309 1.00 43.42  ? 114 TRP A NE1 1 
ATOM   684  C CE2 . TRP A 1 88  ? 120.164 120.664 132.045 1.00 42.66  ? 114 TRP A CE2 1 
ATOM   685  C CE3 . TRP A 1 88  ? 121.949 121.874 130.957 1.00 46.02  ? 114 TRP A CE3 1 
ATOM   686  C CZ2 . TRP A 1 88  ? 119.753 120.095 130.843 1.00 45.42  ? 114 TRP A CZ2 1 
ATOM   687  C CZ3 . TRP A 1 88  ? 121.540 121.307 129.765 1.00 48.03  ? 114 TRP A CZ3 1 
ATOM   688  C CH2 . TRP A 1 88  ? 120.452 120.428 129.717 1.00 46.40  ? 114 TRP A CH2 1 
ATOM   689  N N   . MET A 1 89  ? 124.812 123.179 136.318 1.00 30.84  ? 115 MET A N   1 
ATOM   690  C CA  . MET A 1 89  ? 125.887 123.939 136.946 1.00 41.87  ? 115 MET A CA  1 
ATOM   691  C C   . MET A 1 89  ? 127.242 123.306 136.662 1.00 45.58  ? 115 MET A C   1 
ATOM   692  O O   . MET A 1 89  ? 128.226 124.012 136.401 1.00 57.98  ? 115 MET A O   1 
ATOM   693  C CB  . MET A 1 89  ? 125.647 124.050 138.448 1.00 35.94  ? 115 MET A CB  1 
ATOM   694  C CG  . MET A 1 89  ? 124.615 125.088 138.817 1.00 37.58  ? 115 MET A CG  1 
ATOM   695  S SD  . MET A 1 89  ? 125.075 126.712 138.197 1.00 57.19  ? 115 MET A SD  1 
ATOM   696  C CE  . MET A 1 89  ? 123.630 127.657 138.647 1.00 48.33  ? 115 MET A CE  1 
ATOM   697  N N   . TYR A 1 90  ? 127.312 121.975 136.710 1.00 32.06  ? 116 TYR A N   1 
ATOM   698  C CA  . TYR A 1 90  ? 128.556 121.300 136.361 1.00 33.41  ? 116 TYR A CA  1 
ATOM   699  C C   . TYR A 1 90  ? 128.919 121.522 134.899 1.00 37.21  ? 116 TYR A C   1 
ATOM   700  O O   . TYR A 1 90  ? 130.099 121.693 134.574 1.00 46.09  ? 116 TYR A O   1 
ATOM   701  C CB  . TYR A 1 90  ? 128.445 119.811 136.675 1.00 36.75  ? 116 TYR A CB  1 
ATOM   702  C CG  . TYR A 1 90  ? 128.859 119.460 138.086 1.00 34.67  ? 116 TYR A CG  1 
ATOM   703  C CD1 . TYR A 1 90  ? 130.036 119.957 138.626 1.00 45.31  ? 116 TYR A CD1 1 
ATOM   704  C CD2 . TYR A 1 90  ? 128.073 118.641 138.879 1.00 30.92  ? 116 TYR A CD2 1 
ATOM   705  C CE1 . TYR A 1 90  ? 130.420 119.639 139.912 1.00 47.13  ? 116 TYR A CE1 1 
ATOM   706  C CE2 . TYR A 1 90  ? 128.448 118.319 140.165 1.00 39.39  ? 116 TYR A CE2 1 
ATOM   707  C CZ  . TYR A 1 90  ? 129.622 118.821 140.677 1.00 45.33  ? 116 TYR A CZ  1 
ATOM   708  O OH  . TYR A 1 90  ? 130.000 118.504 141.960 1.00 45.93  ? 116 TYR A OH  1 
ATOM   709  N N   . LEU A 1 91  ? 127.924 121.541 134.011 1.00 36.12  ? 117 LEU A N   1 
ATOM   710  C CA  . LEU A 1 91  ? 128.190 121.860 132.610 1.00 34.66  ? 117 LEU A CA  1 
ATOM   711  C C   . LEU A 1 91  ? 128.725 123.281 132.453 1.00 43.86  ? 117 LEU A C   1 
ATOM   712  O O   . LEU A 1 91  ? 129.640 123.528 131.656 1.00 54.72  ? 117 LEU A O   1 
ATOM   713  C CB  . LEU A 1 91  ? 126.920 121.673 131.782 1.00 37.63  ? 117 LEU A CB  1 
ATOM   714  C CG  . LEU A 1 91  ? 127.016 122.019 130.297 1.00 38.77  ? 117 LEU A CG  1 
ATOM   715  C CD1 . LEU A 1 91  ? 128.011 121.107 129.603 1.00 39.47  ? 117 LEU A CD1 1 
ATOM   716  C CD2 . LEU A 1 91  ? 125.650 121.927 129.641 1.00 43.47  ? 117 LEU A CD2 1 
ATOM   717  N N   . VAL A 1 92  ? 128.158 124.231 133.201 1.00 37.73  ? 118 VAL A N   1 
ATOM   718  C CA  . VAL A 1 92  ? 128.621 125.616 133.141 1.00 29.07  ? 118 VAL A CA  1 
ATOM   719  C C   . VAL A 1 92  ? 130.068 125.719 133.609 1.00 35.28  ? 118 VAL A C   1 
ATOM   720  O O   . VAL A 1 92  ? 130.893 126.408 132.991 1.00 52.02  ? 118 VAL A O   1 
ATOM   721  C CB  . VAL A 1 92  ? 127.689 126.520 133.967 1.00 33.09  ? 118 VAL A CB  1 
ATOM   722  C CG1 . VAL A 1 92  ? 128.341 127.860 134.235 1.00 39.69  ? 118 VAL A CG1 1 
ATOM   723  C CG2 . VAL A 1 92  ? 126.365 126.710 133.247 1.00 37.38  ? 118 VAL A CG2 1 
ATOM   724  N N   . TYR A 1 93  ? 130.404 125.029 134.700 1.00 28.02  ? 119 TYR A N   1 
ATOM   725  C CA  . TYR A 1 93  ? 131.786 125.043 135.170 1.00 31.71  ? 119 TYR A CA  1 
ATOM   726  C C   . TYR A 1 93  ? 132.724 124.347 134.189 1.00 41.62  ? 119 TYR A C   1 
ATOM   727  O O   . TYR A 1 93  ? 133.880 124.760 134.041 1.00 47.43  ? 119 TYR A O   1 
ATOM   728  C CB  . TYR A 1 93  ? 131.878 124.408 136.556 1.00 33.21  ? 119 TYR A CB  1 
ATOM   729  C CG  . TYR A 1 93  ? 131.575 125.373 137.680 1.00 36.27  ? 119 TYR A CG  1 
ATOM   730  C CD1 . TYR A 1 93  ? 130.270 125.640 138.060 1.00 39.86  ? 119 TYR A CD1 1 
ATOM   731  C CD2 . TYR A 1 93  ? 132.597 126.019 138.356 1.00 39.82  ? 119 TYR A CD2 1 
ATOM   732  C CE1 . TYR A 1 93  ? 129.991 126.523 139.082 1.00 41.40  ? 119 TYR A CE1 1 
ATOM   733  C CE2 . TYR A 1 93  ? 132.327 126.902 139.379 1.00 39.93  ? 119 TYR A CE2 1 
ATOM   734  C CZ  . TYR A 1 93  ? 131.023 127.150 139.738 1.00 41.38  ? 119 TYR A CZ  1 
ATOM   735  O OH  . TYR A 1 93  ? 130.748 128.030 140.758 1.00 43.99  ? 119 TYR A OH  1 
ATOM   736  N N   . THR A 1 94  ? 132.248 123.306 133.500 1.00 34.47  ? 120 THR A N   1 
ATOM   737  C CA  . THR A 1 94  ? 133.053 122.680 132.455 1.00 24.31  ? 120 THR A CA  1 
ATOM   738  C C   . THR A 1 94  ? 133.339 123.656 131.321 1.00 35.13  ? 120 THR A C   1 
ATOM   739  O O   . THR A 1 94  ? 134.465 123.718 130.810 1.00 47.99  ? 120 THR A O   1 
ATOM   740  C CB  . THR A 1 94  ? 132.343 121.439 131.917 1.00 33.59  ? 120 THR A CB  1 
ATOM   741  O OG1 . THR A 1 94  ? 132.100 120.523 132.992 1.00 45.49  ? 120 THR A OG1 1 
ATOM   742  C CG2 . THR A 1 94  ? 133.190 120.755 130.860 1.00 36.33  ? 120 THR A CG2 1 
ATOM   743  N N   . ILE A 1 95  ? 132.328 124.425 130.913 1.00 32.43  ? 121 ILE A N   1 
ATOM   744  C CA  . ILE A 1 95  ? 132.528 125.424 129.866 1.00 31.14  ? 121 ILE A CA  1 
ATOM   745  C C   . ILE A 1 95  ? 133.531 126.478 130.320 1.00 37.87  ? 121 ILE A C   1 
ATOM   746  O O   . ILE A 1 95  ? 134.399 126.907 129.548 1.00 48.55  ? 121 ILE A O   1 
ATOM   747  C CB  . ILE A 1 95  ? 131.183 126.057 129.465 1.00 27.57  ? 121 ILE A CB  1 
ATOM   748  C CG1 . ILE A 1 95  ? 130.305 125.036 128.745 1.00 32.27  ? 121 ILE A CG1 1 
ATOM   749  C CG2 . ILE A 1 95  ? 131.400 127.275 128.588 1.00 35.32  ? 121 ILE A CG2 1 
ATOM   750  C CD1 . ILE A 1 95  ? 128.999 125.605 128.245 1.00 36.93  ? 121 ILE A CD1 1 
ATOM   751  N N   . MET A 1 96  ? 133.430 126.909 131.579 1.00 29.29  ? 122 MET A N   1 
ATOM   752  C CA  . MET A 1 96  ? 134.377 127.893 132.099 1.00 30.74  ? 122 MET A CA  1 
ATOM   753  C C   . MET A 1 96  ? 135.800 127.343 132.113 1.00 38.81  ? 122 MET A C   1 
ATOM   754  O O   . MET A 1 96  ? 136.753 128.056 131.772 1.00 48.04  ? 122 MET A O   1 
ATOM   755  C CB  . MET A 1 96  ? 133.953 128.336 133.498 1.00 36.32  ? 122 MET A CB  1 
ATOM   756  C CG  . MET A 1 96  ? 134.780 129.469 134.068 1.00 45.73  ? 122 MET A CG  1 
ATOM   757  S SD  . MET A 1 96  ? 134.041 130.202 135.538 1.00 50.08  ? 122 MET A SD  1 
ATOM   758  C CE  . MET A 1 96  ? 134.012 128.798 136.642 1.00 38.83  ? 122 MET A CE  1 
ATOM   759  N N   . PHE A 1 97  ? 135.964 126.077 132.503 1.00 35.80  ? 123 PHE A N   1 
ATOM   760  C CA  . PHE A 1 97  ? 137.288 125.462 132.504 1.00 34.54  ? 123 PHE A CA  1 
ATOM   761  C C   . PHE A 1 97  ? 137.849 125.357 131.090 1.00 38.91  ? 123 PHE A C   1 
ATOM   762  O O   . PHE A 1 97  ? 139.044 125.598 130.868 1.00 41.37  ? 123 PHE A O   1 
ATOM   763  C CB  . PHE A 1 97  ? 137.216 124.086 133.164 1.00 33.57  ? 123 PHE A CB  1 
ATOM   764  C CG  . PHE A 1 97  ? 138.555 123.460 133.421 1.00 35.84  ? 123 PHE A CG  1 
ATOM   765  C CD1 . PHE A 1 97  ? 139.257 123.747 134.578 1.00 37.66  ? 123 PHE A CD1 1 
ATOM   766  C CD2 . PHE A 1 97  ? 139.105 122.574 132.513 1.00 42.34  ? 123 PHE A CD2 1 
ATOM   767  C CE1 . PHE A 1 97  ? 140.486 123.169 134.820 1.00 44.11  ? 123 PHE A CE1 1 
ATOM   768  C CE2 . PHE A 1 97  ? 140.334 121.993 132.750 1.00 45.01  ? 123 PHE A CE2 1 
ATOM   769  C CZ  . PHE A 1 97  ? 141.025 122.290 133.904 1.00 45.36  ? 123 PHE A CZ  1 
ATOM   770  N N   . LEU A 1 98  ? 137.001 124.997 130.123 1.00 42.37  ? 124 LEU A N   1 
ATOM   771  C CA  . LEU A 1 98  ? 137.445 124.944 128.733 1.00 37.08  ? 124 LEU A CA  1 
ATOM   772  C C   . LEU A 1 98  ? 137.874 126.319 128.240 1.00 37.68  ? 124 LEU A C   1 
ATOM   773  O O   . LEU A 1 98  ? 138.879 126.445 127.530 1.00 45.54  ? 124 LEU A O   1 
ATOM   774  C CB  . LEU A 1 98  ? 136.336 124.380 127.847 1.00 32.21  ? 124 LEU A CB  1 
ATOM   775  C CG  . LEU A 1 98  ? 136.549 122.961 127.322 1.00 39.52  ? 124 LEU A CG  1 
ATOM   776  C CD1 . LEU A 1 98  ? 136.789 121.993 128.466 1.00 37.76  ? 124 LEU A CD1 1 
ATOM   777  C CD2 . LEU A 1 98  ? 135.359 122.522 126.486 1.00 40.96  ? 124 LEU A CD2 1 
ATOM   778  N N   . GLY A 1 99  ? 137.126 127.361 128.606 1.00 37.41  ? 125 GLY A N   1 
ATOM   779  C CA  . GLY A 1 99  ? 137.516 128.706 128.218 1.00 42.85  ? 125 GLY A CA  1 
ATOM   780  C C   . GLY A 1 99  ? 138.831 129.135 128.839 1.00 42.37  ? 125 GLY A C   1 
ATOM   781  O O   . GLY A 1 99  ? 139.649 129.794 128.190 1.00 45.03  ? 125 GLY A O   1 
ATOM   782  N N   . ALA A 1 100 ? 139.055 128.768 130.102 1.00 38.37  ? 126 ALA A N   1 
ATOM   783  C CA  . ALA A 1 100 ? 140.324 129.092 130.746 1.00 37.34  ? 126 ALA A CA  1 
ATOM   784  C C   . ALA A 1 100 ? 141.486 128.373 130.071 1.00 41.63  ? 126 ALA A C   1 
ATOM   785  O O   . ALA A 1 100 ? 142.554 128.965 129.863 1.00 43.90  ? 126 ALA A O   1 
ATOM   786  C CB  . ALA A 1 100 ? 140.262 128.743 132.232 1.00 38.77  ? 126 ALA A CB  1 
ATOM   787  N N   . LEU A 1 101 ? 141.297 127.101 129.710 1.00 47.06  ? 127 LEU A N   1 
ATOM   788  C CA  . LEU A 1 101 ? 142.340 126.384 128.979 1.00 35.75  ? 127 LEU A CA  1 
ATOM   789  C C   . LEU A 1 101 ? 142.605 127.022 127.622 1.00 38.22  ? 127 LEU A C   1 
ATOM   790  O O   . LEU A 1 101 ? 143.763 127.144 127.201 1.00 46.75  ? 127 LEU A O   1 
ATOM   791  C CB  . LEU A 1 101 ? 141.957 124.915 128.808 1.00 35.88  ? 127 LEU A CB  1 
ATOM   792  C CG  . LEU A 1 101 ? 142.349 123.958 129.932 1.00 41.14  ? 127 LEU A CG  1 
ATOM   793  C CD1 . LEU A 1 101 ? 141.916 122.542 129.596 1.00 45.47  ? 127 LEU A CD1 1 
ATOM   794  C CD2 . LEU A 1 101 ? 143.844 124.015 130.179 1.00 41.06  ? 127 LEU A CD2 1 
ATOM   795  N N   . GLY A 1 102 ? 141.547 127.432 126.920 1.00 43.33  ? 128 GLY A N   1 
ATOM   796  C CA  . GLY A 1 102 ? 141.728 128.084 125.635 1.00 41.82  ? 128 GLY A CA  1 
ATOM   797  C C   . GLY A 1 102 ? 142.444 129.413 125.741 1.00 45.55  ? 128 GLY A C   1 
ATOM   798  O O   . GLY A 1 102 ? 143.226 129.772 124.856 1.00 52.54  ? 128 GLY A O   1 
ATOM   799  N N   . MET A 1 103 ? 142.191 130.161 126.816 1.00 49.49  ? 129 MET A N   1 
ATOM   800  C CA  . MET A 1 103 ? 142.943 131.390 127.046 1.00 44.54  ? 129 MET A CA  1 
ATOM   801  C C   . MET A 1 103 ? 144.399 131.101 127.377 1.00 49.94  ? 129 MET A C   1 
ATOM   802  O O   . MET A 1 103 ? 145.288 131.847 126.953 1.00 57.43  ? 129 MET A O   1 
ATOM   803  C CB  . MET A 1 103 ? 142.309 132.205 128.173 1.00 47.84  ? 129 MET A CB  1 
ATOM   804  C CG  . MET A 1 103 ? 141.020 132.905 127.798 1.00 53.25  ? 129 MET A CG  1 
ATOM   805  S SD  . MET A 1 103 ? 140.454 134.002 129.109 1.00 63.40  ? 129 MET A SD  1 
ATOM   806  C CE  . MET A 1 103 ? 141.870 135.080 129.274 1.00 53.08  ? 129 MET A CE  1 
ATOM   807  N N   . MET A 1 104 ? 144.665 130.034 128.134 1.00 49.03  ? 130 MET A N   1 
ATOM   808  C CA  . MET A 1 104 ? 146.044 129.709 128.483 1.00 44.55  ? 130 MET A CA  1 
ATOM   809  C C   . MET A 1 104 ? 146.842 129.299 127.252 1.00 46.85  ? 130 MET A C   1 
ATOM   810  O O   . MET A 1 104 ? 147.961 129.779 127.037 1.00 49.55  ? 130 MET A O   1 
ATOM   811  C CB  . MET A 1 104 ? 146.077 128.600 129.534 1.00 50.58  ? 130 MET A CB  1 
ATOM   812  C CG  . MET A 1 104 ? 147.471 128.297 130.056 1.00 50.35  ? 130 MET A CG  1 
ATOM   813  S SD  . MET A 1 104 ? 147.547 126.835 131.106 1.00 69.38  ? 130 MET A SD  1 
ATOM   814  C CE  . MET A 1 104 ? 147.212 125.544 129.913 1.00 54.95  ? 130 MET A CE  1 
ATOM   815  N N   . LEU A 1 105 ? 146.283 128.415 126.426 1.00 48.47  ? 131 LEU A N   1 
ATOM   816  C CA  . LEU A 1 105 ? 147.001 127.925 125.257 1.00 42.43  ? 131 LEU A CA  1 
ATOM   817  C C   . LEU A 1 105 ? 146.863 128.831 124.041 1.00 40.14  ? 131 LEU A C   1 
ATOM   818  O O   . LEU A 1 105 ? 147.565 128.615 123.048 1.00 46.79  ? 131 LEU A O   1 
ATOM   819  C CB  . LEU A 1 105 ? 146.525 126.517 124.896 1.00 44.71  ? 131 LEU A CB  1 
ATOM   820  C CG  . LEU A 1 105 ? 146.802 125.426 125.928 1.00 44.13  ? 131 LEU A CG  1 
ATOM   821  C CD1 . LEU A 1 105 ? 146.317 124.080 125.422 1.00 44.35  ? 131 LEU A CD1 1 
ATOM   822  C CD2 . LEU A 1 105 ? 148.282 125.373 126.267 1.00 48.90  ? 131 LEU A CD2 1 
ATOM   823  N N   . GLY A 1 106 ? 145.991 129.830 124.090 1.00 48.53  ? 132 GLY A N   1 
ATOM   824  C CA  . GLY A 1 106 ? 145.779 130.696 122.943 1.00 52.13  ? 132 GLY A CA  1 
ATOM   825  C C   . GLY A 1 106 ? 145.152 130.000 121.756 1.00 56.81  ? 132 GLY A C   1 
ATOM   826  O O   . GLY A 1 106 ? 145.523 130.282 120.610 1.00 65.15  ? 132 GLY A O   1 
ATOM   827  N N   . LEU A 1 107 ? 144.207 129.097 122.001 1.00 52.73  ? 133 LEU A N   1 
ATOM   828  C CA  . LEU A 1 107 ? 143.520 128.349 120.953 1.00 52.25  ? 133 LEU A CA  1 
ATOM   829  C C   . LEU A 1 107 ? 142.097 128.881 120.844 1.00 49.55  ? 133 LEU A C   1 
ATOM   830  O O   . LEU A 1 107 ? 141.311 128.752 121.789 1.00 55.03  ? 133 LEU A O   1 
ATOM   831  C CB  . LEU A 1 107 ? 143.528 126.854 121.263 1.00 51.10  ? 133 LEU A CB  1 
ATOM   832  C CG  . LEU A 1 107 ? 142.883 125.927 120.234 1.00 54.69  ? 133 LEU A CG  1 
ATOM   833  C CD1 . LEU A 1 107 ? 143.573 126.058 118.885 1.00 56.81  ? 133 LEU A CD1 1 
ATOM   834  C CD2 . LEU A 1 107 ? 142.922 124.489 120.723 1.00 51.14  ? 133 LEU A CD2 1 
ATOM   835  N N   . CYS A 1 108 ? 141.767 129.470 119.695 1.00 54.60  ? 134 CYS A N   1 
ATOM   836  C CA  . CYS A 1 108 ? 140.472 130.113 119.475 1.00 56.26  ? 134 CYS A CA  1 
ATOM   837  C C   . CYS A 1 108 ? 140.198 131.138 120.578 1.00 56.42  ? 134 CYS A C   1 
ATOM   838  O O   . CYS A 1 108 ? 139.279 131.012 121.387 1.00 63.10  ? 134 CYS A O   1 
ATOM   839  C CB  . CYS A 1 108 ? 139.354 129.071 119.375 1.00 59.33  ? 134 CYS A CB  1 
ATOM   840  S SG  . CYS A 1 108 ? 139.460 128.018 117.910 1.00 67.03  ? 134 CYS A SG  1 
ATOM   841  N N   . TYR A 1 109 ? 141.055 132.161 120.580 1.00 51.38  ? 135 TYR A N   1 
ATOM   842  C CA  . TYR A 1 109 ? 141.177 133.051 121.730 1.00 51.20  ? 135 TYR A CA  1 
ATOM   843  C C   . TYR A 1 109 ? 139.871 133.771 122.043 1.00 59.21  ? 135 TYR A C   1 
ATOM   844  O O   . TYR A 1 109 ? 139.486 133.877 123.213 1.00 70.74  ? 135 TYR A O   1 
ATOM   845  C CB  . TYR A 1 109 ? 142.300 134.055 121.483 1.00 56.45  ? 135 TYR A CB  1 
ATOM   846  C CG  . TYR A 1 109 ? 142.576 134.970 122.647 1.00 54.02  ? 135 TYR A CG  1 
ATOM   847  C CD1 . TYR A 1 109 ? 143.174 134.492 123.801 1.00 54.35  ? 135 TYR A CD1 1 
ATOM   848  C CD2 . TYR A 1 109 ? 142.254 136.317 122.586 1.00 52.66  ? 135 TYR A CD2 1 
ATOM   849  C CE1 . TYR A 1 109 ? 143.432 135.326 124.866 1.00 58.72  ? 135 TYR A CE1 1 
ATOM   850  C CE2 . TYR A 1 109 ? 142.510 137.158 123.644 1.00 51.51  ? 135 TYR A CE2 1 
ATOM   851  C CZ  . TYR A 1 109 ? 143.100 136.659 124.782 1.00 57.95  ? 135 TYR A CZ  1 
ATOM   852  O OH  . TYR A 1 109 ? 143.357 137.496 125.842 1.00 63.03  ? 135 TYR A OH  1 
ATOM   853  N N   . ARG A 1 110 ? 139.172 134.272 121.023 1.00 46.66  ? 136 ARG A N   1 
ATOM   854  C CA  . ARG A 1 110 ? 137.959 135.044 121.284 1.00 51.88  ? 136 ARG A CA  1 
ATOM   855  C C   . ARG A 1 110 ? 136.845 134.164 121.843 1.00 59.61  ? 136 ARG A C   1 
ATOM   856  O O   . ARG A 1 110 ? 136.160 134.551 122.801 1.00 61.47  ? 136 ARG A O   1 
ATOM   857  C CB  . ARG A 1 110 ? 137.504 135.750 120.008 1.00 49.73  ? 136 ARG A CB  1 
ATOM   858  C CG  . ARG A 1 110 ? 137.928 137.211 119.915 1.00 54.38  ? 136 ARG A CG  1 
ATOM   859  C CD  . ARG A 1 110 ? 139.410 137.388 120.204 1.00 57.91  ? 136 ARG A CD  1 
ATOM   860  N NE  . ARG A 1 110 ? 139.827 138.782 120.126 1.00 56.25  ? 136 ARG A NE  1 
ATOM   861  C CZ  . ARG A 1 110 ? 140.391 139.336 119.062 1.00 57.19  ? 136 ARG A CZ  1 
ATOM   862  N NH1 . ARG A 1 110 ? 140.624 138.640 117.962 1.00 57.88  ? 136 ARG A NH1 1 
ATOM   863  N NH2 . ARG A 1 110 ? 140.731 140.621 119.103 1.00 53.26  ? 136 ARG A NH2 1 
ATOM   864  N N   . ILE A 1 111 ? 136.657 132.975 121.268 1.00 49.14  ? 137 ILE A N   1 
ATOM   865  C CA  . ILE A 1 111 ? 135.620 132.073 121.756 1.00 39.83  ? 137 ILE A CA  1 
ATOM   866  C C   . ILE A 1 111 ? 135.931 131.624 123.177 1.00 42.28  ? 137 ILE A C   1 
ATOM   867  O O   . ILE A 1 111 ? 135.038 131.563 124.030 1.00 57.08  ? 137 ILE A O   1 
ATOM   868  C CB  . ILE A 1 111 ? 135.458 130.876 120.803 1.00 45.66  ? 137 ILE A CB  1 
ATOM   869  C CG1 . ILE A 1 111 ? 135.030 131.354 119.416 1.00 44.99  ? 137 ILE A CG1 1 
ATOM   870  C CG2 . ILE A 1 111 ? 134.447 129.885 121.354 1.00 49.62  ? 137 ILE A CG2 1 
ATOM   871  C CD1 . ILE A 1 111 ? 134.835 130.233 118.420 1.00 47.55  ? 137 ILE A CD1 1 
ATOM   872  N N   . SER A 1 112 ? 137.198 131.314 123.458 1.00 29.95  ? 138 SER A N   1 
ATOM   873  C CA  . SER A 1 112 ? 137.577 130.911 124.808 1.00 40.42  ? 138 SER A CA  1 
ATOM   874  C C   . SER A 1 112 ? 137.373 132.049 125.799 1.00 43.55  ? 138 SER A C   1 
ATOM   875  O O   . SER A 1 112 ? 136.919 131.825 126.929 1.00 55.08  ? 138 SER A O   1 
ATOM   876  C CB  . SER A 1 112 ? 139.028 130.437 124.824 1.00 46.18  ? 138 SER A CB  1 
ATOM   877  O OG  . SER A 1 112 ? 139.230 129.387 123.895 1.00 49.54  ? 138 SER A OG  1 
ATOM   878  N N   . CYS A 1 113 ? 137.690 133.279 125.392 1.00 35.27  ? 139 CYS A N   1 
ATOM   879  C CA  . CYS A 1 113 ? 137.491 134.420 126.276 1.00 37.60  ? 139 CYS A CA  1 
ATOM   880  C C   . CYS A 1 113 ? 136.015 134.627 126.582 1.00 41.75  ? 139 CYS A C   1 
ATOM   881  O O   . CYS A 1 113 ? 135.653 134.908 127.728 1.00 54.50  ? 139 CYS A O   1 
ATOM   882  C CB  . CYS A 1 113 ? 138.094 135.679 125.657 1.00 41.76  ? 139 CYS A CB  1 
ATOM   883  S SG  . CYS A 1 113 ? 139.897 135.738 125.703 1.00 62.74  ? 139 CYS A SG  1 
ATOM   884  N N   . VAL A 1 114 ? 135.147 134.485 125.579 1.00 34.57  ? 140 VAL A N   1 
ATOM   885  C CA  . VAL A 1 114 ? 133.712 134.611 125.827 1.00 35.48  ? 140 VAL A CA  1 
ATOM   886  C C   . VAL A 1 114 ? 133.220 133.491 126.741 1.00 39.14  ? 140 VAL A C   1 
ATOM   887  O O   . VAL A 1 114 ? 132.433 133.725 127.673 1.00 50.22  ? 140 VAL A O   1 
ATOM   888  C CB  . VAL A 1 114 ? 132.940 134.635 124.497 1.00 35.39  ? 140 VAL A CB  1 
ATOM   889  C CG1 . VAL A 1 114 ? 131.445 134.597 124.750 1.00 33.53  ? 140 VAL A CG1 1 
ATOM   890  C CG2 . VAL A 1 114 ? 133.310 135.870 123.697 1.00 39.69  ? 140 VAL A CG2 1 
ATOM   891  N N   . LEU A 1 115 ? 133.674 132.258 126.489 1.00 33.33  ? 141 LEU A N   1 
ATOM   892  C CA  . LEU A 1 115 ? 133.232 131.110 127.271 1.00 30.69  ? 141 LEU A CA  1 
ATOM   893  C C   . LEU A 1 115 ? 133.743 131.151 128.701 1.00 36.66  ? 141 LEU A C   1 
ATOM   894  O O   . LEU A 1 115 ? 133.173 130.482 129.568 1.00 48.82  ? 141 LEU A O   1 
ATOM   895  C CB  . LEU A 1 115 ? 133.682 129.811 126.603 1.00 28.94  ? 141 LEU A CB  1 
ATOM   896  C CG  . LEU A 1 115 ? 133.015 129.444 125.279 1.00 34.96  ? 141 LEU A CG  1 
ATOM   897  C CD1 . LEU A 1 115 ? 133.594 128.149 124.741 1.00 34.96  ? 141 LEU A CD1 1 
ATOM   898  C CD2 . LEU A 1 115 ? 131.509 129.333 125.447 1.00 40.77  ? 141 LEU A CD2 1 
ATOM   899  N N   . PHE A 1 116 ? 134.814 131.893 128.964 1.00 34.80  ? 142 PHE A N   1 
ATOM   900  C CA  . PHE A 1 116 ? 135.217 132.132 130.343 1.00 32.81  ? 142 PHE A CA  1 
ATOM   901  C C   . PHE A 1 116 ? 134.524 133.342 130.951 1.00 37.31  ? 142 PHE A C   1 
ATOM   902  O O   . PHE A 1 116 ? 134.248 133.348 132.155 1.00 46.04  ? 142 PHE A O   1 
ATOM   903  C CB  . PHE A 1 116 ? 136.734 132.314 130.437 1.00 28.69  ? 142 PHE A CB  1 
ATOM   904  C CG  . PHE A 1 116 ? 137.226 132.558 131.834 1.00 34.20  ? 142 PHE A CG  1 
ATOM   905  C CD1 . PHE A 1 116 ? 137.443 131.502 132.696 1.00 37.79  ? 142 PHE A CD1 1 
ATOM   906  C CD2 . PHE A 1 116 ? 137.470 133.842 132.284 1.00 37.75  ? 142 PHE A CD2 1 
ATOM   907  C CE1 . PHE A 1 116 ? 137.893 131.722 133.980 1.00 36.83  ? 142 PHE A CE1 1 
ATOM   908  C CE2 . PHE A 1 116 ? 137.919 134.065 133.567 1.00 37.03  ? 142 PHE A CE2 1 
ATOM   909  C CZ  . PHE A 1 116 ? 138.130 133.004 134.414 1.00 36.04  ? 142 PHE A CZ  1 
ATOM   910  N N   . LEU A 1 117 ? 134.232 134.363 130.144 1.00 31.01  ? 143 LEU A N   1 
ATOM   911  C CA  . LEU A 1 117 ? 133.686 135.604 130.677 1.00 28.18  ? 143 LEU A CA  1 
ATOM   912  C C   . LEU A 1 117 ? 132.234 135.445 131.102 1.00 34.44  ? 143 LEU A C   1 
ATOM   913  O O   . LEU A 1 117 ? 131.846 135.912 132.179 1.00 46.69  ? 143 LEU A O   1 
ATOM   914  C CB  . LEU A 1 117 ? 133.819 136.717 129.639 1.00 29.07  ? 143 LEU A CB  1 
ATOM   915  C CG  . LEU A 1 117 ? 133.442 138.128 130.088 1.00 31.77  ? 143 LEU A CG  1 
ATOM   916  C CD1 . LEU A 1 117 ? 134.433 138.641 131.119 1.00 37.76  ? 143 LEU A CD1 1 
ATOM   917  C CD2 . LEU A 1 117 ? 133.371 139.064 128.898 1.00 27.87  ? 143 LEU A CD2 1 
ATOM   918  N N   . LEU A 1 118 ? 131.409 134.793 130.275 1.00 32.05  ? 144 LEU A N   1 
ATOM   919  C CA  . LEU A 1 118 ? 129.977 134.775 130.575 1.00 28.37  ? 144 LEU A CA  1 
ATOM   920  C C   . LEU A 1 118 ? 129.640 133.912 131.789 1.00 35.84  ? 144 LEU A C   1 
ATOM   921  O O   . LEU A 1 118 ? 128.980 134.420 132.717 1.00 45.48  ? 144 LEU A O   1 
ATOM   922  C CB  . LEU A 1 118 ? 129.185 134.362 129.329 1.00 25.21  ? 144 LEU A CB  1 
ATOM   923  C CG  . LEU A 1 118 ? 128.718 135.474 128.385 1.00 32.33  ? 144 LEU A CG  1 
ATOM   924  C CD1 . LEU A 1 118 ? 129.889 136.242 127.794 1.00 38.59  ? 144 LEU A CD1 1 
ATOM   925  C CD2 . LEU A 1 118 ? 127.846 134.898 127.282 1.00 35.95  ? 144 LEU A CD2 1 
ATOM   926  N N   . PRO A 1 119 ? 130.037 132.634 131.864 1.00 26.05  ? 145 PRO A N   1 
ATOM   927  C CA  . PRO A 1 119 ? 129.724 131.855 133.073 1.00 24.27  ? 145 PRO A CA  1 
ATOM   928  C C   . PRO A 1 119 ? 130.336 132.422 134.340 1.00 35.48  ? 145 PRO A C   1 
ATOM   929  O O   . PRO A 1 119 ? 129.721 132.318 135.409 1.00 44.86  ? 145 PRO A O   1 
ATOM   930  C CB  . PRO A 1 119 ? 130.291 130.467 132.749 1.00 25.77  ? 145 PRO A CB  1 
ATOM   931  C CG  . PRO A 1 119 ? 130.311 130.408 131.276 1.00 32.57  ? 145 PRO A CG  1 
ATOM   932  C CD  . PRO A 1 119 ? 130.671 131.788 130.839 1.00 34.54  ? 145 PRO A CD  1 
ATOM   933  N N   . TYR A 1 120 ? 131.527 133.020 134.255 1.00 33.59  ? 146 TYR A N   1 
ATOM   934  C CA  . TYR A 1 120 ? 132.148 133.592 135.444 1.00 29.62  ? 146 TYR A CA  1 
ATOM   935  C C   . TYR A 1 120 ? 131.298 134.714 136.015 1.00 37.51  ? 146 TYR A C   1 
ATOM   936  O O   . TYR A 1 120 ? 131.072 134.777 137.229 1.00 43.16  ? 146 TYR A O   1 
ATOM   937  C CB  . TYR A 1 120 ? 133.551 134.099 135.117 1.00 31.38  ? 146 TYR A CB  1 
ATOM   938  C CG  . TYR A 1 120 ? 134.336 134.575 136.316 1.00 31.50  ? 146 TYR A CG  1 
ATOM   939  C CD1 . TYR A 1 120 ? 134.245 135.886 136.755 1.00 34.60  ? 146 TYR A CD1 1 
ATOM   940  C CD2 . TYR A 1 120 ? 135.176 133.714 137.003 1.00 33.46  ? 146 TYR A CD2 1 
ATOM   941  C CE1 . TYR A 1 120 ? 134.961 136.323 137.847 1.00 36.82  ? 146 TYR A CE1 1 
ATOM   942  C CE2 . TYR A 1 120 ? 135.896 134.143 138.095 1.00 33.87  ? 146 TYR A CE2 1 
ATOM   943  C CZ  . TYR A 1 120 ? 135.785 135.448 138.512 1.00 35.89  ? 146 TYR A CZ  1 
ATOM   944  O OH  . TYR A 1 120 ? 136.504 135.876 139.602 1.00 46.71  ? 146 TYR A OH  1 
ATOM   945  N N   . TRP A 1 121 ? 130.799 135.602 135.155 1.00 34.83  ? 147 TRP A N   1 
ATOM   946  C CA  . TRP A 1 121 ? 129.973 136.695 135.648 1.00 35.27  ? 147 TRP A CA  1 
ATOM   947  C C   . TRP A 1 121 ? 128.600 136.208 136.084 1.00 33.37  ? 147 TRP A C   1 
ATOM   948  O O   . TRP A 1 121 ? 128.013 136.778 137.010 1.00 46.34  ? 147 TRP A O   1 
ATOM   949  C CB  . TRP A 1 121 ? 129.853 137.789 134.590 1.00 36.07  ? 147 TRP A CB  1 
ATOM   950  C CG  . TRP A 1 121 ? 131.040 138.691 134.567 1.00 30.56  ? 147 TRP A CG  1 
ATOM   951  C CD1 . TRP A 1 121 ? 132.067 138.669 133.676 1.00 33.94  ? 147 TRP A CD1 1 
ATOM   952  C CD2 . TRP A 1 121 ? 131.337 139.739 135.496 1.00 31.22  ? 147 TRP A CD2 1 
ATOM   953  N NE1 . TRP A 1 121 ? 132.982 139.644 133.982 1.00 41.37  ? 147 TRP A NE1 1 
ATOM   954  C CE2 . TRP A 1 121 ? 132.556 140.315 135.098 1.00 37.47  ? 147 TRP A CE2 1 
ATOM   955  C CE3 . TRP A 1 121 ? 130.687 140.250 136.622 1.00 35.73  ? 147 TRP A CE3 1 
ATOM   956  C CZ2 . TRP A 1 121 ? 133.139 141.375 135.784 1.00 40.52  ? 147 TRP A CZ2 1 
ATOM   957  C CZ3 . TRP A 1 121 ? 131.267 141.301 137.301 1.00 35.33  ? 147 TRP A CZ3 1 
ATOM   958  C CH2 . TRP A 1 121 ? 132.480 141.852 136.881 1.00 33.51  ? 147 TRP A CH2 1 
ATOM   959  N N   . TYR A 1 122 ? 128.085 135.143 135.464 1.00 24.94  ? 148 TYR A N   1 
ATOM   960  C CA  . TYR A 1 122 ? 126.840 134.561 135.958 1.00 26.60  ? 148 TYR A CA  1 
ATOM   961  C C   . TYR A 1 122 ? 127.009 134.035 137.378 1.00 29.17  ? 148 TYR A C   1 
ATOM   962  O O   . TYR A 1 122 ? 126.168 134.291 138.250 1.00 43.94  ? 148 TYR A O   1 
ATOM   963  C CB  . TYR A 1 122 ? 126.370 133.449 135.023 1.00 29.65  ? 148 TYR A CB  1 
ATOM   964  C CG  . TYR A 1 122 ? 125.154 132.704 135.518 1.00 29.66  ? 148 TYR A CG  1 
ATOM   965  C CD1 . TYR A 1 122 ? 123.952 133.361 135.728 1.00 32.84  ? 148 TYR A CD1 1 
ATOM   966  C CD2 . TYR A 1 122 ? 125.204 131.339 135.762 1.00 32.05  ? 148 TYR A CD2 1 
ATOM   967  C CE1 . TYR A 1 122 ? 122.838 132.683 136.178 1.00 32.39  ? 148 TYR A CE1 1 
ATOM   968  C CE2 . TYR A 1 122 ? 124.095 130.654 136.211 1.00 31.31  ? 148 TYR A CE2 1 
ATOM   969  C CZ  . TYR A 1 122 ? 122.916 131.330 136.415 1.00 32.67  ? 148 TYR A CZ  1 
ATOM   970  O OH  . TYR A 1 122 ? 121.808 130.650 136.863 1.00 44.04  ? 148 TYR A OH  1 
ATOM   971  N N   . VAL A 1 123 ? 128.106 133.321 137.637 1.00 31.73  ? 149 VAL A N   1 
ATOM   972  C CA  . VAL A 1 123 ? 128.371 132.825 138.984 1.00 34.56  ? 149 VAL A CA  1 
ATOM   973  C C   . VAL A 1 123 ? 128.591 133.985 139.949 1.00 37.63  ? 149 VAL A C   1 
ATOM   974  O O   . VAL A 1 123 ? 128.109 133.963 141.088 1.00 42.25  ? 149 VAL A O   1 
ATOM   975  C CB  . VAL A 1 123 ? 129.570 131.860 138.973 1.00 36.74  ? 149 VAL A CB  1 
ATOM   976  C CG1 . VAL A 1 123 ? 129.943 131.457 140.389 1.00 37.29  ? 149 VAL A CG1 1 
ATOM   977  C CG2 . VAL A 1 123 ? 129.255 130.633 138.139 1.00 36.31  ? 149 VAL A CG2 1 
ATOM   978  N N   . PHE A 1 124 ? 129.317 135.015 139.509 1.00 33.75  ? 150 PHE A N   1 
ATOM   979  C CA  . PHE A 1 124 ? 129.603 136.157 140.372 1.00 31.47  ? 150 PHE A CA  1 
ATOM   980  C C   . PHE A 1 124 ? 128.326 136.884 140.776 1.00 31.40  ? 150 PHE A C   1 
ATOM   981  O O   . PHE A 1 124 ? 128.166 137.263 141.942 1.00 36.87  ? 150 PHE A O   1 
ATOM   982  C CB  . PHE A 1 124 ? 130.567 137.107 139.662 1.00 31.82  ? 150 PHE A CB  1 
ATOM   983  C CG  . PHE A 1 124 ? 131.109 138.197 140.538 1.00 32.13  ? 150 PHE A CG  1 
ATOM   984  C CD1 . PHE A 1 124 ? 132.194 137.965 141.361 1.00 33.00  ? 150 PHE A CD1 1 
ATOM   985  C CD2 . PHE A 1 124 ? 130.547 139.460 140.521 1.00 38.62  ? 150 PHE A CD2 1 
ATOM   986  C CE1 . PHE A 1 124 ? 132.700 138.967 142.161 1.00 36.63  ? 150 PHE A CE1 1 
ATOM   987  C CE2 . PHE A 1 124 ? 131.049 140.466 141.319 1.00 38.11  ? 150 PHE A CE2 1 
ATOM   988  C CZ  . PHE A 1 124 ? 132.126 140.219 142.139 1.00 38.53  ? 150 PHE A CZ  1 
ATOM   989  N N   . LEU A 1 125 ? 127.407 137.089 139.833 1.00 32.05  ? 151 LEU A N   1 
ATOM   990  C CA  . LEU A 1 125 ? 126.146 137.750 140.140 1.00 30.25  ? 151 LEU A CA  1 
ATOM   991  C C   . LEU A 1 125 ? 125.134 136.827 140.804 1.00 37.13  ? 151 LEU A C   1 
ATOM   992  O O   . LEU A 1 125 ? 124.129 137.315 141.328 1.00 45.64  ? 151 LEU A O   1 
ATOM   993  C CB  . LEU A 1 125 ? 125.534 138.342 138.868 1.00 33.18  ? 151 LEU A CB  1 
ATOM   994  C CG  . LEU A 1 125 ? 126.362 139.401 138.140 1.00 36.28  ? 151 LEU A CG  1 
ATOM   995  C CD1 . LEU A 1 125 ? 125.597 139.947 136.949 1.00 38.28  ? 151 LEU A CD1 1 
ATOM   996  C CD2 . LEU A 1 125 ? 126.761 140.523 139.084 1.00 37.73  ? 151 LEU A CD2 1 
ATOM   997  N N   . LEU A 1 126 ? 125.369 135.513 140.795 1.00 39.91  ? 152 LEU A N   1 
ATOM   998  C CA  . LEU A 1 126 ? 124.432 134.589 141.424 1.00 32.26  ? 152 LEU A CA  1 
ATOM   999  C C   . LEU A 1 126 ? 124.487 134.631 142.946 1.00 39.91  ? 152 LEU A C   1 
ATOM   1000 O O   . LEU A 1 126 ? 123.550 134.155 143.595 1.00 48.84  ? 152 LEU A O   1 
ATOM   1001 C CB  . LEU A 1 126 ? 124.699 133.163 140.944 1.00 32.22  ? 152 LEU A CB  1 
ATOM   1002 C CG  . LEU A 1 126 ? 123.527 132.430 140.293 1.00 34.95  ? 152 LEU A CG  1 
ATOM   1003 C CD1 . LEU A 1 126 ? 123.957 131.044 139.863 1.00 39.46  ? 152 LEU A CD1 1 
ATOM   1004 C CD2 . LEU A 1 126 ? 122.343 132.352 141.237 1.00 41.34  ? 152 LEU A CD2 1 
ATOM   1005 N N   . ASP A 1 127 ? 125.545 135.186 143.532 1.00 43.26  ? 153 ASP A N   1 
ATOM   1006 C CA  . ASP A 1 127 ? 125.701 135.163 144.984 1.00 38.96  ? 153 ASP A CA  1 
ATOM   1007 C C   . ASP A 1 127 ? 126.527 136.361 145.421 1.00 42.68  ? 153 ASP A C   1 
ATOM   1008 O O   . ASP A 1 127 ? 127.673 136.515 144.990 1.00 46.89  ? 153 ASP A O   1 
ATOM   1009 C CB  . ASP A 1 127 ? 126.362 133.863 145.439 1.00 39.02  ? 153 ASP A CB  1 
ATOM   1010 C CG  . ASP A 1 127 ? 126.456 133.754 146.946 1.00 49.07  ? 153 ASP A CG  1 
ATOM   1011 O OD1 . ASP A 1 127 ? 125.411 133.538 147.594 1.00 50.40  ? 153 ASP A OD1 1 
ATOM   1012 O OD2 . ASP A 1 127 ? 127.576 133.886 147.484 1.00 55.02  ? 153 ASP A OD2 1 
ATOM   1013 N N   . LYS A 1 128 ? 125.946 137.200 146.278 1.00 36.76  ? 154 LYS A N   1 
ATOM   1014 C CA  . LYS A 1 128 ? 126.630 138.372 146.806 1.00 36.55  ? 154 LYS A CA  1 
ATOM   1015 C C   . LYS A 1 128 ? 127.486 138.066 148.025 1.00 41.47  ? 154 LYS A C   1 
ATOM   1016 O O   . LYS A 1 128 ? 128.239 138.939 148.469 1.00 48.86  ? 154 LYS A O   1 
ATOM   1017 C CB  . LYS A 1 128 ? 125.615 139.463 147.165 1.00 36.65  ? 154 LYS A CB  1 
ATOM   1018 C CG  . LYS A 1 128 ? 124.842 140.003 145.979 1.00 40.16  ? 154 LYS A CG  1 
ATOM   1019 C CD  . LYS A 1 128 ? 123.952 141.166 146.377 1.00 44.12  ? 154 LYS A CD  1 
ATOM   1020 C CE  . LYS A 1 128 ? 122.868 140.729 147.340 1.00 39.78  ? 154 LYS A CE  1 
ATOM   1021 N NZ  . LYS A 1 128 ? 121.967 141.854 147.701 1.00 36.42  ? 154 LYS A NZ  1 
ATOM   1022 N N   . THR A 1 129 ? 127.393 136.857 148.573 1.00 39.69  ? 155 THR A N   1 
ATOM   1023 C CA  . THR A 1 129 ? 128.165 136.491 149.751 1.00 39.96  ? 155 THR A CA  1 
ATOM   1024 C C   . THR A 1 129 ? 129.588 136.072 149.417 1.00 44.15  ? 155 THR A C   1 
ATOM   1025 O O   . THR A 1 129 ? 130.421 135.991 150.325 1.00 51.09  ? 155 THR A O   1 
ATOM   1026 C CB  . THR A 1 129 ? 127.469 135.358 150.504 1.00 43.90  ? 155 THR A CB  1 
ATOM   1027 O OG1 . THR A 1 129 ? 127.614 134.136 149.770 1.00 50.77  ? 155 THR A OG1 1 
ATOM   1028 C CG2 . THR A 1 129 ? 125.994 135.662 150.665 1.00 43.71  ? 155 THR A CG2 1 
ATOM   1029 N N   . SER A 1 130 ? 129.886 135.806 148.146 1.00 42.64  ? 156 SER A N   1 
ATOM   1030 C CA  . SER A 1 130 ? 131.212 135.384 147.719 1.00 40.84  ? 156 SER A CA  1 
ATOM   1031 C C   . SER A 1 130 ? 131.925 136.460 146.909 1.00 44.20  ? 156 SER A C   1 
ATOM   1032 O O   . SER A 1 130 ? 132.835 136.149 146.136 1.00 52.72  ? 156 SER A O   1 
ATOM   1033 C CB  . SER A 1 130 ? 131.121 134.088 146.913 1.00 43.74  ? 156 SER A CB  1 
ATOM   1034 O OG  . SER A 1 130 ? 130.309 134.259 145.765 1.00 46.96  ? 156 SER A OG  1 
ATOM   1035 N N   . TRP A 1 131 ? 131.528 137.719 147.070 1.00 39.28  ? 157 TRP A N   1 
ATOM   1036 C CA  . TRP A 1 131 ? 132.178 138.827 146.386 1.00 37.07  ? 157 TRP A CA  1 
ATOM   1037 C C   . TRP A 1 131 ? 133.421 139.250 147.155 1.00 42.27  ? 157 TRP A C   1 
ATOM   1038 O O   . TRP A 1 131 ? 133.376 139.424 148.377 1.00 48.32  ? 157 TRP A O   1 
ATOM   1039 C CB  . TRP A 1 131 ? 131.232 140.018 146.242 1.00 36.36  ? 157 TRP A CB  1 
ATOM   1040 C CG  . TRP A 1 131 ? 130.168 139.847 145.212 1.00 39.70  ? 157 TRP A CG  1 
ATOM   1041 C CD1 . TRP A 1 131 ? 129.789 138.688 144.611 1.00 42.61  ? 157 TRP A CD1 1 
ATOM   1042 C CD2 . TRP A 1 131 ? 129.347 140.877 144.654 1.00 39.22  ? 157 TRP A CD2 1 
ATOM   1043 N NE1 . TRP A 1 131 ? 128.776 138.929 143.716 1.00 43.51  ? 157 TRP A NE1 1 
ATOM   1044 C CE2 . TRP A 1 131 ? 128.488 140.267 143.724 1.00 40.11  ? 157 TRP A CE2 1 
ATOM   1045 C CE3 . TRP A 1 131 ? 129.254 142.257 144.854 1.00 39.16  ? 157 TRP A CE3 1 
ATOM   1046 C CZ2 . TRP A 1 131 ? 127.548 140.988 142.994 1.00 42.79  ? 157 TRP A CZ2 1 
ATOM   1047 C CZ3 . TRP A 1 131 ? 128.323 142.969 144.130 1.00 42.24  ? 157 TRP A CZ3 1 
ATOM   1048 C CH2 . TRP A 1 131 ? 127.482 142.335 143.212 1.00 44.61  ? 157 TRP A CH2 1 
ATOM   1049 N N   . ASN A 1 132 ? 134.525 139.414 146.436 1.00 43.38  ? 158 ASN A N   1 
ATOM   1050 C CA  . ASN A 1 132 ? 135.734 139.997 146.991 1.00 38.91  ? 158 ASN A CA  1 
ATOM   1051 C C   . ASN A 1 132 ? 136.441 140.760 145.879 1.00 46.75  ? 158 ASN A C   1 
ATOM   1052 O O   . ASN A 1 132 ? 136.051 140.696 144.710 1.00 56.56  ? 158 ASN A O   1 
ATOM   1053 C CB  . ASN A 1 132 ? 136.631 138.928 147.620 1.00 38.27  ? 158 ASN A CB  1 
ATOM   1054 C CG  . ASN A 1 132 ? 136.642 137.641 146.833 1.00 46.40  ? 158 ASN A CG  1 
ATOM   1055 O OD1 . ASN A 1 132 ? 137.195 137.575 145.737 1.00 59.33  ? 158 ASN A OD1 1 
ATOM   1056 N ND2 . ASN A 1 132 ? 136.035 136.602 147.392 1.00 46.41  ? 158 ASN A ND2 1 
ATOM   1057 N N   . ASN A 1 133 ? 137.488 141.493 146.254 1.00 43.97  ? 159 ASN A N   1 
ATOM   1058 C CA  . ASN A 1 133 ? 138.176 142.339 145.286 1.00 43.02  ? 159 ASN A CA  1 
ATOM   1059 C C   . ASN A 1 133 ? 138.890 141.511 144.225 1.00 47.48  ? 159 ASN A C   1 
ATOM   1060 O O   . ASN A 1 133 ? 138.916 141.890 143.047 1.00 53.17  ? 159 ASN A O   1 
ATOM   1061 C CB  . ASN A 1 133 ? 139.157 143.262 146.005 1.00 39.96  ? 159 ASN A CB  1 
ATOM   1062 C CG  . ASN A 1 133 ? 138.467 144.198 146.974 1.00 46.02  ? 159 ASN A CG  1 
ATOM   1063 O OD1 . ASN A 1 133 ? 137.973 145.255 146.587 1.00 49.89  ? 159 ASN A OD1 1 
ATOM   1064 N ND2 . ASN A 1 133 ? 138.430 143.814 148.243 1.00 50.18  ? 159 ASN A ND2 1 
ATOM   1065 N N   . HIS A 1 134 ? 139.464 140.373 144.614 1.00 38.25  ? 160 HIS A N   1 
ATOM   1066 C CA  . HIS A 1 134 ? 140.258 139.599 143.672 1.00 44.70  ? 160 HIS A CA  1 
ATOM   1067 C C   . HIS A 1 134 ? 139.416 138.810 142.679 1.00 51.24  ? 160 HIS A C   1 
ATOM   1068 O O   . HIS A 1 134 ? 139.968 138.309 141.696 1.00 58.66  ? 160 HIS A O   1 
ATOM   1069 C CB  . HIS A 1 134 ? 141.208 138.656 144.417 1.00 46.46  ? 160 HIS A CB  1 
ATOM   1070 C CG  . HIS A 1 134 ? 140.522 137.626 145.257 1.00 46.55  ? 160 HIS A CG  1 
ATOM   1071 N ND1 . HIS A 1 134 ? 140.466 137.704 146.631 1.00 48.47  ? 160 HIS A ND1 1 
ATOM   1072 C CD2 . HIS A 1 134 ? 139.888 136.478 144.919 1.00 47.27  ? 160 HIS A CD2 1 
ATOM   1073 C CE1 . HIS A 1 134 ? 139.814 136.657 147.104 1.00 42.59  ? 160 HIS A CE1 1 
ATOM   1074 N NE2 . HIS A 1 134 ? 139.452 135.898 146.085 1.00 48.81  ? 160 HIS A NE2 1 
ATOM   1075 N N   . SER A 1 135 ? 138.106 138.694 142.894 1.00 31.46  ? 161 SER A N   1 
ATOM   1076 C CA  . SER A 1 135 ? 137.232 138.103 141.888 1.00 31.55  ? 161 SER A CA  1 
ATOM   1077 C C   . SER A 1 135 ? 136.721 139.153 140.911 1.00 39.09  ? 161 SER A C   1 
ATOM   1078 O O   . SER A 1 135 ? 136.605 138.889 139.706 1.00 51.65  ? 161 SER A O   1 
ATOM   1079 C CB  . SER A 1 135 ? 136.054 137.397 142.560 1.00 34.94  ? 161 SER A CB  1 
ATOM   1080 O OG  . SER A 1 135 ? 136.504 136.455 143.516 1.00 48.82  ? 161 SER A OG  1 
ATOM   1081 N N   . TYR A 1 136 ? 136.426 140.348 141.423 1.00 34.49  ? 162 TYR A N   1 
ATOM   1082 C CA  . TYR A 1 136 ? 136.131 141.481 140.558 1.00 36.10  ? 162 TYR A CA  1 
ATOM   1083 C C   . TYR A 1 136 ? 137.307 141.768 139.634 1.00 50.16  ? 162 TYR A C   1 
ATOM   1084 O O   . TYR A 1 136 ? 137.119 142.082 138.451 1.00 58.14  ? 162 TYR A O   1 
ATOM   1085 C CB  . TYR A 1 136 ? 135.792 142.699 141.418 1.00 36.66  ? 162 TYR A CB  1 
ATOM   1086 C CG  . TYR A 1 136 ? 135.196 143.868 140.674 1.00 39.74  ? 162 TYR A CG  1 
ATOM   1087 C CD1 . TYR A 1 136 ? 133.978 143.755 140.023 1.00 41.74  ? 162 TYR A CD1 1 
ATOM   1088 C CD2 . TYR A 1 136 ? 135.837 145.097 140.651 1.00 42.69  ? 162 TYR A CD2 1 
ATOM   1089 C CE1 . TYR A 1 136 ? 133.427 144.826 139.351 1.00 43.02  ? 162 TYR A CE1 1 
ATOM   1090 C CE2 . TYR A 1 136 ? 135.294 146.173 139.984 1.00 40.91  ? 162 TYR A CE2 1 
ATOM   1091 C CZ  . TYR A 1 136 ? 134.091 146.033 139.335 1.00 45.90  ? 162 TYR A CZ  1 
ATOM   1092 O OH  . TYR A 1 136 ? 133.548 147.105 138.669 1.00 53.38  ? 162 TYR A OH  1 
ATOM   1093 N N   . LEU A 1 137 ? 138.531 141.642 140.154 1.00 42.63  ? 163 LEU A N   1 
ATOM   1094 C CA  . LEU A 1 137 ? 139.713 141.843 139.323 1.00 32.44  ? 163 LEU A CA  1 
ATOM   1095 C C   . LEU A 1 137 ? 139.806 140.793 138.223 1.00 38.69  ? 163 LEU A C   1 
ATOM   1096 O O   . LEU A 1 137 ? 140.155 141.118 137.084 1.00 50.02  ? 163 LEU A O   1 
ATOM   1097 C CB  . LEU A 1 137 ? 140.973 141.830 140.185 1.00 31.60  ? 163 LEU A CB  1 
ATOM   1098 C CG  . LEU A 1 137 ? 142.257 142.251 139.471 1.00 39.30  ? 163 LEU A CG  1 
ATOM   1099 C CD1 . LEU A 1 137 ? 142.136 143.672 138.955 1.00 44.56  ? 163 LEU A CD1 1 
ATOM   1100 C CD2 . LEU A 1 137 ? 143.454 142.115 140.392 1.00 41.82  ? 163 LEU A CD2 1 
ATOM   1101 N N   . TYR A 1 138 ? 139.498 139.531 138.538 1.00 36.86  ? 164 TYR A N   1 
ATOM   1102 C CA  . TYR A 1 138 ? 139.531 138.492 137.512 1.00 36.84  ? 164 TYR A CA  1 
ATOM   1103 C C   . TYR A 1 138 ? 138.493 138.759 136.431 1.00 34.45  ? 164 TYR A C   1 
ATOM   1104 O O   . TYR A 1 138 ? 138.776 138.610 135.234 1.00 45.23  ? 164 TYR A O   1 
ATOM   1105 C CB  . TYR A 1 138 ? 139.291 137.115 138.129 1.00 34.94  ? 164 TYR A CB  1 
ATOM   1106 C CG  . TYR A 1 138 ? 140.285 136.698 139.186 1.00 35.86  ? 164 TYR A CG  1 
ATOM   1107 C CD1 . TYR A 1 138 ? 141.542 137.277 139.261 1.00 42.93  ? 164 TYR A CD1 1 
ATOM   1108 C CD2 . TYR A 1 138 ? 139.962 135.715 140.110 1.00 37.88  ? 164 TYR A CD2 1 
ATOM   1109 C CE1 . TYR A 1 138 ? 142.446 136.893 140.232 1.00 44.28  ? 164 TYR A CE1 1 
ATOM   1110 C CE2 . TYR A 1 138 ? 140.857 135.326 141.082 1.00 39.91  ? 164 TYR A CE2 1 
ATOM   1111 C CZ  . TYR A 1 138 ? 142.096 135.917 141.139 1.00 45.84  ? 164 TYR A CZ  1 
ATOM   1112 O OH  . TYR A 1 138 ? 142.990 135.526 142.107 1.00 54.79  ? 164 TYR A OH  1 
ATOM   1113 N N   . GLY A 1 139 ? 137.284 139.152 136.836 1.00 25.04  ? 165 GLY A N   1 
ATOM   1114 C CA  . GLY A 1 139 ? 136.262 139.478 135.856 1.00 25.20  ? 165 GLY A CA  1 
ATOM   1115 C C   . GLY A 1 139 ? 136.665 140.631 134.957 1.00 36.51  ? 165 GLY A C   1 
ATOM   1116 O O   . GLY A 1 139 ? 136.498 140.568 133.735 1.00 48.43  ? 165 GLY A O   1 
ATOM   1117 N N   . LEU A 1 140 ? 137.218 141.693 135.548 1.00 32.64  ? 166 LEU A N   1 
ATOM   1118 C CA  . LEU A 1 140 ? 137.651 142.836 134.753 1.00 34.72  ? 166 LEU A CA  1 
ATOM   1119 C C   . LEU A 1 140 ? 138.793 142.464 133.816 1.00 36.71  ? 166 LEU A C   1 
ATOM   1120 O O   . LEU A 1 140 ? 138.832 142.920 132.669 1.00 44.16  ? 166 LEU A O   1 
ATOM   1121 C CB  . LEU A 1 140 ? 138.062 143.988 135.666 1.00 37.02  ? 166 LEU A CB  1 
ATOM   1122 C CG  . LEU A 1 140 ? 136.949 144.638 136.487 1.00 39.71  ? 166 LEU A CG  1 
ATOM   1123 C CD1 . LEU A 1 140 ? 137.504 145.794 137.294 1.00 40.35  ? 166 LEU A CD1 1 
ATOM   1124 C CD2 . LEU A 1 140 ? 135.815 145.104 135.592 1.00 39.26  ? 166 LEU A CD2 1 
ATOM   1125 N N   . LEU A 1 141 ? 139.732 141.638 134.283 1.00 32.75  ? 167 LEU A N   1 
ATOM   1126 C CA  . LEU A 1 141 ? 140.848 141.242 133.432 1.00 33.53  ? 167 LEU A CA  1 
ATOM   1127 C C   . LEU A 1 141 ? 140.377 140.388 132.263 1.00 38.82  ? 167 LEU A C   1 
ATOM   1128 O O   . LEU A 1 141 ? 140.869 140.543 131.140 1.00 52.24  ? 167 LEU A O   1 
ATOM   1129 C CB  . LEU A 1 141 ? 141.902 140.501 134.253 1.00 35.10  ? 167 LEU A CB  1 
ATOM   1130 C CG  . LEU A 1 141 ? 142.749 141.360 135.192 1.00 36.81  ? 167 LEU A CG  1 
ATOM   1131 C CD1 . LEU A 1 141 ? 143.763 140.505 135.930 1.00 41.24  ? 167 LEU A CD1 1 
ATOM   1132 C CD2 . LEU A 1 141 ? 143.442 142.470 134.424 1.00 39.54  ? 167 LEU A CD2 1 
ATOM   1133 N N   . ALA A 1 142 ? 139.423 139.485 132.501 1.00 31.50  ? 168 ALA A N   1 
ATOM   1134 C CA  . ALA A 1 142 ? 138.866 138.709 131.397 1.00 33.39  ? 168 ALA A CA  1 
ATOM   1135 C C   . ALA A 1 142 ? 138.129 139.608 130.411 1.00 33.49  ? 168 ALA A C   1 
ATOM   1136 O O   . ALA A 1 142 ? 138.259 139.443 129.189 1.00 45.74  ? 168 ALA A O   1 
ATOM   1137 C CB  . ALA A 1 142 ? 137.937 137.622 131.935 1.00 36.25  ? 168 ALA A CB  1 
ATOM   1138 N N   . PHE A 1 143 ? 137.366 140.576 130.923 1.00 30.54  ? 169 PHE A N   1 
ATOM   1139 C CA  . PHE A 1 143 ? 136.661 141.507 130.049 1.00 32.99  ? 169 PHE A CA  1 
ATOM   1140 C C   . PHE A 1 143 ? 137.635 142.306 129.192 1.00 38.07  ? 169 PHE A C   1 
ATOM   1141 O O   . PHE A 1 143 ? 137.387 142.532 128.002 1.00 40.90  ? 169 PHE A O   1 
ATOM   1142 C CB  . PHE A 1 143 ? 135.786 142.438 130.886 1.00 35.51  ? 169 PHE A CB  1 
ATOM   1143 C CG  . PHE A 1 143 ? 135.009 143.434 130.081 1.00 35.60  ? 169 PHE A CG  1 
ATOM   1144 C CD1 . PHE A 1 143 ? 133.922 143.037 129.325 1.00 39.60  ? 169 PHE A CD1 1 
ATOM   1145 C CD2 . PHE A 1 143 ? 135.355 144.772 130.094 1.00 37.83  ? 169 PHE A CD2 1 
ATOM   1146 C CE1 . PHE A 1 143 ? 133.202 143.953 128.589 1.00 37.60  ? 169 PHE A CE1 1 
ATOM   1147 C CE2 . PHE A 1 143 ? 134.638 145.692 129.359 1.00 40.27  ? 169 PHE A CE2 1 
ATOM   1148 C CZ  . PHE A 1 143 ? 133.561 145.282 128.607 1.00 39.52  ? 169 PHE A CZ  1 
ATOM   1149 N N   . GLN A 1 144 ? 138.749 142.745 129.780 1.00 42.93  ? 170 GLN A N   1 
ATOM   1150 C CA  . GLN A 1 144 ? 139.742 143.497 129.019 1.00 40.97  ? 170 GLN A CA  1 
ATOM   1151 C C   . GLN A 1 144 ? 140.438 142.616 127.990 1.00 45.05  ? 170 GLN A C   1 
ATOM   1152 O O   . GLN A 1 144 ? 140.629 143.029 126.841 1.00 51.57  ? 170 GLN A O   1 
ATOM   1153 C CB  . GLN A 1 144 ? 140.770 144.118 129.963 1.00 38.08  ? 170 GLN A CB  1 
ATOM   1154 C CG  . GLN A 1 144 ? 140.205 145.128 130.940 1.00 41.77  ? 170 GLN A CG  1 
ATOM   1155 C CD  . GLN A 1 144 ? 141.177 145.451 132.054 1.00 52.38  ? 170 GLN A CD  1 
ATOM   1156 O OE1 . GLN A 1 144 ? 142.379 145.230 131.924 1.00 52.97  ? 170 GLN A OE1 1 
ATOM   1157 N NE2 . GLN A 1 144 ? 140.660 145.966 133.163 1.00 54.33  ? 170 GLN A NE2 1 
ATOM   1158 N N   . LEU A 1 145 ? 140.822 141.398 128.379 1.00 39.66  ? 171 LEU A N   1 
ATOM   1159 C CA  . LEU A 1 145 ? 141.543 140.506 127.480 1.00 30.65  ? 171 LEU A CA  1 
ATOM   1160 C C   . LEU A 1 145 ? 140.656 139.914 126.395 1.00 37.48  ? 171 LEU A C   1 
ATOM   1161 O O   . LEU A 1 145 ? 141.183 139.315 125.453 1.00 43.72  ? 171 LEU A O   1 
ATOM   1162 C CB  . LEU A 1 145 ? 142.206 139.379 128.274 1.00 29.98  ? 171 LEU A CB  1 
ATOM   1163 C CG  . LEU A 1 145 ? 143.651 139.596 128.730 1.00 41.95  ? 171 LEU A CG  1 
ATOM   1164 C CD1 . LEU A 1 145 ? 143.777 140.821 129.618 1.00 45.62  ? 171 LEU A CD1 1 
ATOM   1165 C CD2 . LEU A 1 145 ? 144.170 138.364 129.447 1.00 42.38  ? 171 LEU A CD2 1 
ATOM   1166 N N   . THR A 1 146 ? 139.334 140.056 126.505 1.00 40.14  ? 172 THR A N   1 
ATOM   1167 C CA  . THR A 1 146 ? 138.460 139.587 125.433 1.00 34.92  ? 172 THR A CA  1 
ATOM   1168 C C   . THR A 1 146 ? 138.730 140.333 124.131 1.00 43.79  ? 172 THR A C   1 
ATOM   1169 O O   . THR A 1 146 ? 138.718 139.733 123.050 1.00 50.57  ? 172 THR A O   1 
ATOM   1170 C CB  . THR A 1 146 ? 136.996 139.738 125.843 1.00 39.87  ? 172 THR A CB  1 
ATOM   1171 O OG1 . THR A 1 146 ? 136.764 139.027 127.065 1.00 47.64  ? 172 THR A OG1 1 
ATOM   1172 C CG2 . THR A 1 146 ? 136.081 139.181 124.768 1.00 39.59  ? 172 THR A CG2 1 
ATOM   1173 N N   . PHE A 1 147 ? 138.984 141.640 124.211 1.00 52.73  ? 173 PHE A N   1 
ATOM   1174 C CA  . PHE A 1 147 ? 139.180 142.452 123.017 1.00 45.86  ? 173 PHE A CA  1 
ATOM   1175 C C   . PHE A 1 147 ? 140.632 142.533 122.565 1.00 47.99  ? 173 PHE A C   1 
ATOM   1176 O O   . PHE A 1 147 ? 140.881 142.807 121.386 1.00 52.22  ? 173 PHE A O   1 
ATOM   1177 C CB  . PHE A 1 147 ? 138.660 143.874 123.246 1.00 43.55  ? 173 PHE A CB  1 
ATOM   1178 C CG  . PHE A 1 147 ? 137.201 143.941 123.580 1.00 50.81  ? 173 PHE A CG  1 
ATOM   1179 C CD1 . PHE A 1 147 ? 136.244 143.713 122.607 1.00 52.99  ? 173 PHE A CD1 1 
ATOM   1180 C CD2 . PHE A 1 147 ? 136.785 144.245 124.863 1.00 53.55  ? 173 PHE A CD2 1 
ATOM   1181 C CE1 . PHE A 1 147 ? 134.900 143.777 122.911 1.00 55.43  ? 173 PHE A CE1 1 
ATOM   1182 C CE2 . PHE A 1 147 ? 135.443 144.310 125.172 1.00 53.52  ? 173 PHE A CE2 1 
ATOM   1183 C CZ  . PHE A 1 147 ? 134.500 144.077 124.195 1.00 54.75  ? 173 PHE A CZ  1 
ATOM   1184 N N   . MET A 1 148 ? 141.587 142.308 123.459 1.00 54.39  ? 174 MET A N   1 
ATOM   1185 C CA  . MET A 1 148 ? 142.993 142.460 123.119 1.00 52.74  ? 174 MET A CA  1 
ATOM   1186 C C   . MET A 1 148 ? 143.490 141.279 122.295 1.00 54.92  ? 174 MET A C   1 
ATOM   1187 O O   . MET A 1 148 ? 143.045 140.140 122.465 1.00 63.41  ? 174 MET A O   1 
ATOM   1188 C CB  . MET A 1 148 ? 143.834 142.602 124.387 1.00 53.39  ? 174 MET A CB  1 
ATOM   1189 C CG  . MET A 1 148 ? 143.398 143.748 125.280 1.00 51.98  ? 174 MET A CG  1 
ATOM   1190 S SD  . MET A 1 148 ? 144.335 143.854 126.814 1.00 69.24  ? 174 MET A SD  1 
ATOM   1191 C CE  . MET A 1 148 ? 143.504 145.222 127.616 1.00 57.03  ? 174 MET A CE  1 
ATOM   1192 N N   . ASP A 1 149 ? 144.429 141.564 121.391 1.00 57.45  ? 175 ASP A N   1 
ATOM   1193 C CA  . ASP A 1 149 ? 145.037 140.540 120.541 1.00 58.71  ? 175 ASP A CA  1 
ATOM   1194 C C   . ASP A 1 149 ? 146.257 139.970 121.261 1.00 63.44  ? 175 ASP A C   1 
ATOM   1195 O O   . ASP A 1 149 ? 147.401 140.366 121.035 1.00 67.27  ? 175 ASP A O   1 
ATOM   1196 C CB  . ASP A 1 149 ? 145.402 141.121 119.181 1.00 63.08  ? 175 ASP A CB  1 
ATOM   1197 C CG  . ASP A 1 149 ? 144.215 141.744 118.477 1.00 71.02  ? 175 ASP A CG  1 
ATOM   1198 O OD1 . ASP A 1 149 ? 143.740 142.804 118.936 1.00 70.46  ? 175 ASP A OD1 1 
ATOM   1199 O OD2 . ASP A 1 149 ? 143.755 141.174 117.465 1.00 73.88  ? 175 ASP A OD2 1 
ATOM   1200 N N   . ALA A 1 150 ? 145.995 139.016 122.150 1.00 57.83  ? 176 ALA A N   1 
ATOM   1201 C CA  . ALA A 1 150 ? 147.032 138.391 122.957 1.00 55.94  ? 176 ALA A CA  1 
ATOM   1202 C C   . ALA A 1 150 ? 147.554 137.087 122.369 1.00 59.00  ? 176 ALA A C   1 
ATOM   1203 O O   . ALA A 1 150 ? 148.417 136.453 122.983 1.00 61.75  ? 176 ALA A O   1 
ATOM   1204 C CB  . ALA A 1 150 ? 146.513 138.139 124.376 1.00 56.32  ? 176 ALA A CB  1 
ATOM   1205 N N   . ASN A 1 151 ? 147.061 136.669 121.204 1.00 67.01  ? 177 ASN A N   1 
ATOM   1206 C CA  . ASN A 1 151 ? 147.385 135.363 120.645 1.00 65.51  ? 177 ASN A CA  1 
ATOM   1207 C C   . ASN A 1 151 ? 148.383 135.431 119.496 1.00 70.10  ? 177 ASN A C   1 
ATOM   1208 O O   . ASN A 1 151 ? 148.577 134.430 118.800 1.00 73.10  ? 177 ASN A O   1 
ATOM   1209 C CB  . ASN A 1 151 ? 146.108 134.660 120.184 1.00 63.09  ? 177 ASN A CB  1 
ATOM   1210 C CG  . ASN A 1 151 ? 145.350 135.457 119.148 1.00 68.84  ? 177 ASN A CG  1 
ATOM   1211 O OD1 . ASN A 1 151 ? 145.446 136.682 119.099 1.00 71.85  ? 177 ASN A OD1 1 
ATOM   1212 N ND2 . ASN A 1 151 ? 144.587 134.766 118.311 1.00 71.96  ? 177 ASN A ND2 1 
ATOM   1213 N N   . HIS A 1 152 ? 149.022 136.580 119.279 1.00 82.19  ? 178 HIS A N   1 
ATOM   1214 C CA  . HIS A 1 152 ? 149.929 136.737 118.150 1.00 82.15  ? 178 HIS A CA  1 
ATOM   1215 C C   . HIS A 1 152 ? 151.327 136.197 118.415 1.00 83.64  ? 178 HIS A C   1 
ATOM   1216 O O   . HIS A 1 152 ? 152.109 136.070 117.466 1.00 88.04  ? 178 HIS A O   1 
ATOM   1217 C CB  . HIS A 1 152 ? 150.018 138.211 117.750 1.00 83.34  ? 178 HIS A CB  1 
ATOM   1218 C CG  . HIS A 1 152 ? 148.796 138.720 117.055 1.00 84.42  ? 178 HIS A CG  1 
ATOM   1219 N ND1 . HIS A 1 152 ? 148.495 140.062 116.963 1.00 86.35  ? 178 HIS A ND1 1 
ATOM   1220 C CD2 . HIS A 1 152 ? 147.799 138.066 116.413 1.00 85.04  ? 178 HIS A CD2 1 
ATOM   1221 C CE1 . HIS A 1 152 ? 147.364 140.213 116.297 1.00 84.96  ? 178 HIS A CE1 1 
ATOM   1222 N NE2 . HIS A 1 152 ? 146.921 139.017 115.952 1.00 86.00  ? 178 HIS A NE2 1 
ATOM   1223 N N   . TYR A 1 153 ? 151.667 135.877 119.661 1.00 68.96  ? 179 TYR A N   1 
ATOM   1224 C CA  . TYR A 1 153 ? 152.996 135.386 119.993 1.00 68.63  ? 179 TYR A CA  1 
ATOM   1225 C C   . TYR A 1 153 ? 152.883 134.241 120.986 1.00 72.22  ? 179 TYR A C   1 
ATOM   1226 O O   . TYR A 1 153 ? 152.129 134.328 121.959 1.00 76.52  ? 179 TYR A O   1 
ATOM   1227 C CB  . TYR A 1 153 ? 153.870 136.507 120.570 1.00 69.38  ? 179 TYR A CB  1 
ATOM   1228 C CG  . TYR A 1 153 ? 155.207 136.050 121.110 1.00 69.44  ? 179 TYR A CG  1 
ATOM   1229 C CD1 . TYR A 1 153 ? 156.285 135.840 120.263 1.00 72.14  ? 179 TYR A CD1 1 
ATOM   1230 C CD2 . TYR A 1 153 ? 155.396 135.847 122.470 1.00 69.41  ? 179 TYR A CD2 1 
ATOM   1231 C CE1 . TYR A 1 153 ? 157.508 135.430 120.755 1.00 71.98  ? 179 TYR A CE1 1 
ATOM   1232 C CE2 . TYR A 1 153 ? 156.615 135.438 122.969 1.00 67.77  ? 179 TYR A CE2 1 
ATOM   1233 C CZ  . TYR A 1 153 ? 157.667 135.231 122.109 1.00 69.24  ? 179 TYR A CZ  1 
ATOM   1234 O OH  . TYR A 1 153 ? 158.883 134.822 122.603 1.00 72.71  ? 179 TYR A OH  1 
ATOM   1235 N N   . TRP A 1 154 ? 153.635 133.169 120.729 1.00 76.59  ? 180 TRP A N   1 
ATOM   1236 C CA  . TRP A 1 154 ? 153.703 132.003 121.610 1.00 78.11  ? 180 TRP A CA  1 
ATOM   1237 C C   . TRP A 1 154 ? 152.308 131.436 121.887 1.00 77.07  ? 180 TRP A C   1 
ATOM   1238 O O   . TRP A 1 154 ? 151.834 131.401 123.024 1.00 78.47  ? 180 TRP A O   1 
ATOM   1239 C CB  . TRP A 1 154 ? 154.427 132.344 122.916 1.00 80.01  ? 180 TRP A CB  1 
ATOM   1240 C CG  . TRP A 1 154 ? 154.881 131.137 123.679 1.00 83.17  ? 180 TRP A CG  1 
ATOM   1241 C CD1 . TRP A 1 154 ? 155.187 129.911 123.164 1.00 81.51  ? 180 TRP A CD1 1 
ATOM   1242 C CD2 . TRP A 1 154 ? 155.071 131.036 125.096 1.00 87.11  ? 180 TRP A CD2 1 
ATOM   1243 N NE1 . TRP A 1 154 ? 155.562 129.054 124.171 1.00 84.10  ? 180 TRP A NE1 1 
ATOM   1244 C CE2 . TRP A 1 154 ? 155.498 129.720 125.367 1.00 86.25  ? 180 TRP A CE2 1 
ATOM   1245 C CE3 . TRP A 1 154 ? 154.924 131.930 126.161 1.00 84.81  ? 180 TRP A CE3 1 
ATOM   1246 C CZ2 . TRP A 1 154 ? 155.779 129.278 126.658 1.00 83.76  ? 180 TRP A CZ2 1 
ATOM   1247 C CZ3 . TRP A 1 154 ? 155.204 131.488 127.442 1.00 83.90  ? 180 TRP A CZ3 1 
ATOM   1248 C CH2 . TRP A 1 154 ? 155.626 130.174 127.679 1.00 82.58  ? 180 TRP A CH2 1 
ATOM   1249 N N   . SER A 1 155 ? 151.651 130.992 120.819 1.00 64.16  ? 181 SER A N   1 
ATOM   1250 C CA  . SER A 1 155 ? 150.311 130.442 120.940 1.00 64.77  ? 181 SER A CA  1 
ATOM   1251 C C   . SER A 1 155 ? 150.089 129.399 119.855 1.00 68.40  ? 181 SER A C   1 
ATOM   1252 O O   . SER A 1 155 ? 150.769 129.387 118.826 1.00 74.22  ? 181 SER A O   1 
ATOM   1253 C CB  . SER A 1 155 ? 149.245 131.538 120.851 1.00 69.88  ? 181 SER A CB  1 
ATOM   1254 O OG  . SER A 1 155 ? 149.324 132.223 119.614 1.00 77.23  ? 181 SER A OG  1 
ATOM   1255 N N   . VAL A 1 156 ? 149.121 128.516 120.108 1.00 64.05  ? 182 VAL A N   1 
ATOM   1256 C CA  . VAL A 1 156 ? 148.779 127.475 119.144 1.00 62.91  ? 182 VAL A CA  1 
ATOM   1257 C C   . VAL A 1 156 ? 148.158 128.079 117.891 1.00 71.03  ? 182 VAL A C   1 
ATOM   1258 O O   . VAL A 1 156 ? 148.374 127.580 116.778 1.00 80.85  ? 182 VAL A O   1 
ATOM   1259 C CB  . VAL A 1 156 ? 147.846 126.441 119.797 1.00 61.34  ? 182 VAL A CB  1 
ATOM   1260 C CG1 . VAL A 1 156 ? 147.549 125.305 118.836 1.00 66.75  ? 182 VAL A CG1 1 
ATOM   1261 C CG2 . VAL A 1 156 ? 148.466 125.909 121.075 1.00 67.59  ? 182 VAL A CG2 1 
ATOM   1262 N N   . ASP A 1 157 ? 147.374 129.149 118.046 1.00 72.51  ? 183 ASP A N   1 
ATOM   1263 C CA  . ASP A 1 157 ? 146.744 129.779 116.892 1.00 75.34  ? 183 ASP A CA  1 
ATOM   1264 C C   . ASP A 1 157 ? 147.781 130.342 115.929 1.00 77.08  ? 183 ASP A C   1 
ATOM   1265 O O   . ASP A 1 157 ? 147.531 130.405 114.720 1.00 80.21  ? 183 ASP A O   1 
ATOM   1266 C CB  . ASP A 1 157 ? 145.787 130.878 117.356 1.00 75.67  ? 183 ASP A CB  1 
ATOM   1267 C CG  . ASP A 1 157 ? 144.760 131.242 116.302 1.00 80.63  ? 183 ASP A CG  1 
ATOM   1268 O OD1 . ASP A 1 157 ? 144.743 130.596 115.234 1.00 80.26  ? 183 ASP A OD1 1 
ATOM   1269 O OD2 . ASP A 1 157 ? 143.965 132.174 116.545 1.00 81.45  ? 183 ASP A OD2 1 
ATOM   1270 N N   . GLY A 1 158 ? 148.941 130.755 116.439 1.00 76.38  ? 184 GLY A N   1 
ATOM   1271 C CA  . GLY A 1 158 ? 150.015 131.172 115.555 1.00 78.18  ? 184 GLY A CA  1 
ATOM   1272 C C   . GLY A 1 158 ? 150.574 130.021 114.741 1.00 80.12  ? 184 GLY A C   1 
ATOM   1273 O O   . GLY A 1 158 ? 150.892 130.182 113.559 1.00 83.78  ? 184 GLY A O   1 
ATOM   1274 N N   . LEU A 1 159 ? 150.706 128.846 115.360 1.00 71.80  ? 185 LEU A N   1 
ATOM   1275 C CA  . LEU A 1 159 ? 151.189 127.679 114.631 1.00 69.39  ? 185 LEU A CA  1 
ATOM   1276 C C   . LEU A 1 159 ? 150.171 127.194 113.609 1.00 70.76  ? 185 LEU A C   1 
ATOM   1277 O O   . LEU A 1 159 ? 150.554 126.697 112.543 1.00 75.72  ? 185 LEU A O   1 
ATOM   1278 C CB  . LEU A 1 159 ? 151.531 126.552 115.605 1.00 66.39  ? 185 LEU A CB  1 
ATOM   1279 C CG  . LEU A 1 159 ? 152.621 126.850 116.634 1.00 70.31  ? 185 LEU A CG  1 
ATOM   1280 C CD1 . LEU A 1 159 ? 152.876 125.634 117.507 1.00 70.11  ? 185 LEU A CD1 1 
ATOM   1281 C CD2 . LEU A 1 159 ? 153.900 127.296 115.946 1.00 72.55  ? 185 LEU A CD2 1 
ATOM   1282 N N   . LEU A 1 160 ? 148.883 127.327 113.908 1.00 79.00  ? 186 LEU A N   1 
ATOM   1283 C CA  . LEU A 1 160 ? 147.834 126.867 113.008 1.00 81.55  ? 186 LEU A CA  1 
ATOM   1284 C C   . LEU A 1 160 ? 147.328 127.954 112.065 1.00 85.90  ? 186 LEU A C   1 
ATOM   1285 O O   . LEU A 1 160 ? 146.447 127.677 111.245 1.00 85.89  ? 186 LEU A O   1 
ATOM   1286 C CB  . LEU A 1 160 ? 146.659 126.297 113.810 1.00 81.37  ? 186 LEU A CB  1 
ATOM   1287 C CG  . LEU A 1 160 ? 146.728 124.821 114.214 1.00 83.80  ? 186 LEU A CG  1 
ATOM   1288 C CD1 . LEU A 1 160 ? 147.848 124.559 115.209 1.00 82.74  ? 186 LEU A CD1 1 
ATOM   1289 C CD2 . LEU A 1 160 ? 145.391 124.358 114.775 1.00 83.39  ? 186 LEU A CD2 1 
ATOM   1290 N N   . ASN A 1 161 ? 147.853 129.174 112.156 1.00 102.56 ? 187 ASN A N   1 
ATOM   1291 C CA  . ASN A 1 161 ? 147.422 130.258 111.279 1.00 103.46 ? 187 ASN A CA  1 
ATOM   1292 C C   . ASN A 1 161 ? 148.581 131.224 111.089 1.00 106.69 ? 187 ASN A C   1 
ATOM   1293 O O   . ASN A 1 161 ? 149.108 131.760 112.068 1.00 106.74 ? 187 ASN A O   1 
ATOM   1294 C CB  . ASN A 1 161 ? 146.202 130.983 111.853 1.00 104.92 ? 187 ASN A CB  1 
ATOM   1295 C CG  . ASN A 1 161 ? 145.656 132.039 110.912 1.00 104.78 ? 187 ASN A CG  1 
ATOM   1296 O OD1 . ASN A 1 161 ? 145.897 131.998 109.706 1.00 104.39 ? 187 ASN A OD1 1 
ATOM   1297 N ND2 . ASN A 1 161 ? 144.913 132.994 111.462 1.00 104.08 ? 187 ASN A ND2 1 
ATOM   1298 N N   . ALA A 1 162 ? 148.967 131.448 109.831 1.00 114.91 ? 188 ALA A N   1 
ATOM   1299 C CA  . ALA A 1 162 ? 150.120 132.295 109.546 1.00 113.45 ? 188 ALA A CA  1 
ATOM   1300 C C   . ALA A 1 162 ? 149.808 133.775 109.737 1.00 114.68 ? 188 ALA A C   1 
ATOM   1301 O O   . ALA A 1 162 ? 150.704 134.553 110.084 1.00 113.82 ? 188 ALA A O   1 
ATOM   1302 C CB  . ALA A 1 162 ? 150.619 132.041 108.123 1.00 109.33 ? 188 ALA A CB  1 
ATOM   1303 N N   . HIS A 1 163 ? 148.556 134.183 109.514 1.00 123.70 ? 189 HIS A N   1 
ATOM   1304 C CA  . HIS A 1 163 ? 148.213 135.601 109.568 1.00 122.69 ? 189 HIS A CA  1 
ATOM   1305 C C   . HIS A 1 163 ? 148.305 136.180 110.974 1.00 122.53 ? 189 HIS A C   1 
ATOM   1306 O O   . HIS A 1 163 ? 148.465 137.397 111.116 1.00 120.80 ? 189 HIS A O   1 
ATOM   1307 C CB  . HIS A 1 163 ? 146.806 135.824 109.011 1.00 122.44 ? 189 HIS A CB  1 
ATOM   1308 C CG  . HIS A 1 163 ? 146.719 135.706 107.521 1.00 123.55 ? 189 HIS A CG  1 
ATOM   1309 N ND1 . HIS A 1 163 ? 146.948 136.770 106.676 1.00 124.14 ? 189 HIS A ND1 1 
ATOM   1310 C CD2 . HIS A 1 163 ? 146.429 134.650 106.725 1.00 123.26 ? 189 HIS A CD2 1 
ATOM   1311 C CE1 . HIS A 1 163 ? 146.802 136.376 105.424 1.00 123.26 ? 189 HIS A CE1 1 
ATOM   1312 N NE2 . HIS A 1 163 ? 146.487 135.093 105.426 1.00 123.98 ? 189 HIS A NE2 1 
ATOM   1313 N N   . ARG A 1 164 ? 148.211 135.350 112.009 1.00 114.03 ? 190 ARG A N   1 
ATOM   1314 C CA  . ARG A 1 164 ? 148.276 135.801 113.395 1.00 113.92 ? 190 ARG A CA  1 
ATOM   1315 C C   . ARG A 1 164 ? 149.535 135.292 114.091 1.00 113.65 ? 190 ARG A C   1 
ATOM   1316 O O   . ARG A 1 164 ? 149.512 134.933 115.269 1.00 110.92 ? 190 ARG A O   1 
ATOM   1317 C CB  . ARG A 1 164 ? 147.027 135.376 114.161 1.00 110.44 ? 190 ARG A CB  1 
ATOM   1318 C CG  . ARG A 1 164 ? 145.746 136.011 113.643 1.00 110.80 ? 190 ARG A CG  1 
ATOM   1319 C CD  . ARG A 1 164 ? 144.573 135.741 114.569 1.00 110.61 ? 190 ARG A CD  1 
ATOM   1320 N NE  . ARG A 1 164 ? 143.354 136.392 114.102 1.00 112.61 ? 190 ARG A NE  1 
ATOM   1321 C CZ  . ARG A 1 164 ? 143.022 137.646 114.377 1.00 111.67 ? 190 ARG A CZ  1 
ATOM   1322 N NH1 . ARG A 1 164 ? 143.799 138.420 115.118 1.00 110.45 ? 190 ARG A NH1 1 
ATOM   1323 N NH2 . ARG A 1 164 ? 141.883 138.136 113.897 1.00 110.90 ? 190 ARG A NH2 1 
ATOM   1324 N N   . ARG A 1 165 ? 150.648 135.256 113.362 1.00 121.88 ? 191 ARG A N   1 
ATOM   1325 C CA  . ARG A 1 165 ? 151.932 134.800 113.887 1.00 119.95 ? 191 ARG A CA  1 
ATOM   1326 C C   . ARG A 1 165 ? 152.895 135.980 113.901 1.00 119.17 ? 191 ARG A C   1 
ATOM   1327 O O   . ARG A 1 165 ? 153.332 136.440 112.840 1.00 118.20 ? 191 ARG A O   1 
ATOM   1328 C CB  . ARG A 1 165 ? 152.487 133.648 113.050 1.00 118.82 ? 191 ARG A CB  1 
ATOM   1329 C CG  . ARG A 1 165 ? 153.886 133.206 113.448 1.00 118.56 ? 191 ARG A CG  1 
ATOM   1330 C CD  . ARG A 1 165 ? 154.409 132.125 112.515 1.00 119.20 ? 191 ARG A CD  1 
ATOM   1331 N NE  . ARG A 1 165 ? 155.782 131.749 112.829 1.00 120.82 ? 191 ARG A NE  1 
ATOM   1332 C CZ  . ARG A 1 165 ? 156.121 130.773 113.660 1.00 121.11 ? 191 ARG A CZ  1 
ATOM   1333 N NH1 . ARG A 1 165 ? 155.207 130.047 114.284 1.00 120.88 ? 191 ARG A NH1 1 
ATOM   1334 N NH2 . ARG A 1 165 ? 157.409 130.518 113.871 1.00 119.10 ? 191 ARG A NH2 1 
ATOM   1335 N N   . ASN A 1 166 ? 153.218 136.465 115.101 1.00 114.15 ? 192 ASN A N   1 
ATOM   1336 C CA  . ASN A 1 166 ? 154.168 137.562 115.298 1.00 114.86 ? 192 ASN A CA  1 
ATOM   1337 C C   . ASN A 1 166 ? 153.714 138.828 114.566 1.00 115.22 ? 192 ASN A C   1 
ATOM   1338 O O   . ASN A 1 166 ? 154.398 139.355 113.687 1.00 113.28 ? 192 ASN A O   1 
ATOM   1339 C CB  . ASN A 1 166 ? 155.580 137.148 114.868 1.00 114.53 ? 192 ASN A CB  1 
ATOM   1340 C CG  . ASN A 1 166 ? 156.170 136.075 115.762 1.00 115.25 ? 192 ASN A CG  1 
ATOM   1341 O OD1 . ASN A 1 166 ? 155.873 136.013 116.956 1.00 116.00 ? 192 ASN A OD1 1 
ATOM   1342 N ND2 . ASN A 1 166 ? 157.012 135.224 115.189 1.00 112.97 ? 192 ASN A ND2 1 
ATOM   1343 N N   . ALA A 1 167 ? 152.535 139.308 114.948 1.00 105.28 ? 193 ALA A N   1 
ATOM   1344 C CA  . ALA A 1 167 ? 151.962 140.526 114.398 1.00 103.26 ? 193 ALA A CA  1 
ATOM   1345 C C   . ALA A 1 167 ? 151.955 141.626 115.453 1.00 102.78 ? 193 ALA A C   1 
ATOM   1346 O O   . ALA A 1 167 ? 152.152 141.382 116.646 1.00 101.84 ? 193 ALA A O   1 
ATOM   1347 C CB  . ALA A 1 167 ? 150.542 140.274 113.877 1.00 100.32 ? 193 ALA A CB  1 
ATOM   1348 N N   . HIS A 1 168 ? 151.721 142.851 114.996 1.00 88.58  ? 194 HIS A N   1 
ATOM   1349 C CA  . HIS A 1 168 ? 151.732 144.013 115.870 1.00 86.03  ? 194 HIS A CA  1 
ATOM   1350 C C   . HIS A 1 168 ? 150.373 144.209 116.537 1.00 83.93  ? 194 HIS A C   1 
ATOM   1351 O O   . HIS A 1 168 ? 149.336 143.766 116.038 1.00 82.93  ? 194 HIS A O   1 
ATOM   1352 C CB  . HIS A 1 168 ? 152.120 145.268 115.088 1.00 81.75  ? 194 HIS A CB  1 
ATOM   1353 C CG  . HIS A 1 168 ? 153.527 145.249 114.577 1.00 84.93  ? 194 HIS A CG  1 
ATOM   1354 N ND1 . HIS A 1 168 ? 153.966 146.084 113.572 1.00 85.33  ? 194 HIS A ND1 1 
ATOM   1355 C CD2 . HIS A 1 168 ? 154.595 144.497 114.934 1.00 85.82  ? 194 HIS A CD2 1 
ATOM   1356 C CE1 . HIS A 1 168 ? 155.243 145.846 113.331 1.00 85.92  ? 194 HIS A CE1 1 
ATOM   1357 N NE2 . HIS A 1 168 ? 155.649 144.887 114.144 1.00 87.62  ? 194 HIS A NE2 1 
ATOM   1358 N N   . VAL A 1 169 ? 150.396 144.888 117.679 1.00 60.91  ? 195 VAL A N   1 
ATOM   1359 C CA  . VAL A 1 169 ? 149.191 145.158 118.460 1.00 54.15  ? 195 VAL A CA  1 
ATOM   1360 C C   . VAL A 1 169 ? 149.160 146.638 118.823 1.00 57.10  ? 195 VAL A C   1 
ATOM   1361 O O   . VAL A 1 169 ? 150.221 147.268 118.941 1.00 67.68  ? 195 VAL A O   1 
ATOM   1362 C CB  . VAL A 1 169 ? 149.134 144.275 119.716 1.00 53.72  ? 195 VAL A CB  1 
ATOM   1363 C CG1 . VAL A 1 169 ? 148.875 142.827 119.335 1.00 60.79  ? 195 VAL A CG1 1 
ATOM   1364 C CG2 . VAL A 1 169 ? 150.426 144.391 120.503 1.00 51.51  ? 195 VAL A CG2 1 
ATOM   1365 N N   . PRO A 1 170 ? 147.985 147.236 119.003 1.00 41.98  ? 196 PRO A N   1 
ATOM   1366 C CA  . PRO A 1 170 ? 147.923 148.651 119.385 1.00 41.66  ? 196 PRO A CA  1 
ATOM   1367 C C   . PRO A 1 170 ? 148.393 148.866 120.817 1.00 49.96  ? 196 PRO A C   1 
ATOM   1368 O O   . PRO A 1 170 ? 148.443 147.951 121.640 1.00 57.19  ? 196 PRO A O   1 
ATOM   1369 C CB  . PRO A 1 170 ? 146.443 149.001 119.219 1.00 44.92  ? 196 PRO A CB  1 
ATOM   1370 C CG  . PRO A 1 170 ? 145.733 147.699 119.329 1.00 46.85  ? 196 PRO A CG  1 
ATOM   1371 C CD  . PRO A 1 170 ? 146.649 146.682 118.725 1.00 47.02  ? 196 PRO A CD  1 
ATOM   1372 N N   . LEU A 1 171 ? 148.746 150.121 121.104 1.00 42.15  ? 197 LEU A N   1 
ATOM   1373 C CA  . LEU A 1 171 ? 149.305 150.465 122.407 1.00 37.37  ? 197 LEU A CA  1 
ATOM   1374 C C   . LEU A 1 171 ? 148.241 150.492 123.499 1.00 45.21  ? 197 LEU A C   1 
ATOM   1375 O O   . LEU A 1 171 ? 148.561 150.304 124.681 1.00 55.02  ? 197 LEU A O   1 
ATOM   1376 C CB  . LEU A 1 171 ? 150.017 151.814 122.326 1.00 38.55  ? 197 LEU A CB  1 
ATOM   1377 C CG  . LEU A 1 171 ? 150.750 152.299 123.576 1.00 42.34  ? 197 LEU A CG  1 
ATOM   1378 C CD1 . LEU A 1 171 ? 151.824 151.306 123.984 1.00 47.92  ? 197 LEU A CD1 1 
ATOM   1379 C CD2 . LEU A 1 171 ? 151.350 153.672 123.346 1.00 41.52  ? 197 LEU A CD2 1 
ATOM   1380 N N   . TRP A 1 172 ? 146.977 150.719 123.137 1.00 40.06  ? 198 TRP A N   1 
ATOM   1381 C CA  . TRP A 1 172 ? 145.948 150.797 124.165 1.00 37.49  ? 198 TRP A CA  1 
ATOM   1382 C C   . TRP A 1 172 ? 145.708 149.452 124.837 1.00 44.64  ? 198 TRP A C   1 
ATOM   1383 O O   . TRP A 1 172 ? 145.193 149.422 125.959 1.00 54.93  ? 198 TRP A O   1 
ATOM   1384 C CB  . TRP A 1 172 ? 144.645 151.352 123.585 1.00 35.25  ? 198 TRP A CB  1 
ATOM   1385 C CG  . TRP A 1 172 ? 143.947 150.458 122.613 1.00 36.59  ? 198 TRP A CG  1 
ATOM   1386 C CD1 . TRP A 1 172 ? 144.063 150.476 121.256 1.00 40.10  ? 198 TRP A CD1 1 
ATOM   1387 C CD2 . TRP A 1 172 ? 143.003 149.426 122.921 1.00 41.48  ? 198 TRP A CD2 1 
ATOM   1388 N NE1 . TRP A 1 172 ? 143.258 149.513 120.699 1.00 37.13  ? 198 TRP A NE1 1 
ATOM   1389 C CE2 . TRP A 1 172 ? 142.596 148.855 121.701 1.00 33.80  ? 198 TRP A CE2 1 
ATOM   1390 C CE3 . TRP A 1 172 ? 142.466 148.927 124.111 1.00 47.52  ? 198 TRP A CE3 1 
ATOM   1391 C CZ2 . TRP A 1 172 ? 141.680 147.810 121.637 1.00 36.80  ? 198 TRP A CZ2 1 
ATOM   1392 C CZ3 . TRP A 1 172 ? 141.556 147.890 124.044 1.00 45.91  ? 198 TRP A CZ3 1 
ATOM   1393 C CH2 . TRP A 1 172 ? 141.173 147.343 122.816 1.00 42.07  ? 198 TRP A CH2 1 
ATOM   1394 N N   . ASN A 1 173 ? 146.106 148.349 124.198 1.00 38.89  ? 199 ASN A N   1 
ATOM   1395 C CA  . ASN A 1 173 ? 146.057 147.053 124.865 1.00 36.30  ? 199 ASN A CA  1 
ATOM   1396 C C   . ASN A 1 173 ? 146.925 147.049 126.115 1.00 44.53  ? 199 ASN A C   1 
ATOM   1397 O O   . ASN A 1 173 ? 146.529 146.508 127.155 1.00 54.27  ? 199 ASN A O   1 
ATOM   1398 C CB  . ASN A 1 173 ? 146.496 145.950 123.907 1.00 39.92  ? 199 ASN A CB  1 
ATOM   1399 C CG  . ASN A 1 173 ? 145.617 145.862 122.682 1.00 50.35  ? 199 ASN A CG  1 
ATOM   1400 O OD1 . ASN A 1 173 ? 144.502 146.381 122.665 1.00 52.87  ? 199 ASN A OD1 1 
ATOM   1401 N ND2 . ASN A 1 173 ? 146.110 145.194 121.648 1.00 48.72  ? 199 ASN A ND2 1 
ATOM   1402 N N   . TYR A 1 174 ? 148.113 147.646 126.034 1.00 33.94  ? 200 TYR A N   1 
ATOM   1403 C CA  . TYR A 1 174 ? 148.953 147.797 127.215 1.00 32.90  ? 200 TYR A CA  1 
ATOM   1404 C C   . TYR A 1 174 ? 148.455 148.909 128.124 1.00 37.17  ? 200 TYR A C   1 
ATOM   1405 O O   . TYR A 1 174 ? 148.553 148.792 129.353 1.00 48.62  ? 200 TYR A O   1 
ATOM   1406 C CB  . TYR A 1 174 ? 150.398 148.077 126.806 1.00 32.74  ? 200 TYR A CB  1 
ATOM   1407 C CG  . TYR A 1 174 ? 151.073 146.936 126.089 1.00 33.05  ? 200 TYR A CG  1 
ATOM   1408 C CD1 . TYR A 1 174 ? 151.631 145.885 126.795 1.00 27.18  ? 200 TYR A CD1 1 
ATOM   1409 C CD2 . TYR A 1 174 ? 151.162 146.916 124.706 1.00 39.47  ? 200 TYR A CD2 1 
ATOM   1410 C CE1 . TYR A 1 174 ? 152.252 144.844 126.146 1.00 29.19  ? 200 TYR A CE1 1 
ATOM   1411 C CE2 . TYR A 1 174 ? 151.781 145.878 124.050 1.00 37.56  ? 200 TYR A CE2 1 
ATOM   1412 C CZ  . TYR A 1 174 ? 152.323 144.845 124.775 1.00 34.52  ? 200 TYR A CZ  1 
ATOM   1413 O OH  . TYR A 1 174 ? 152.942 143.806 124.125 1.00 37.89  ? 200 TYR A OH  1 
ATOM   1414 N N   . ALA A 1 175 ? 147.932 149.990 127.539 1.00 35.12  ? 201 ALA A N   1 
ATOM   1415 C CA  . ALA A 1 175 ? 147.491 151.129 128.337 1.00 34.74  ? 201 ALA A CA  1 
ATOM   1416 C C   . ALA A 1 175 ? 146.354 150.749 129.277 1.00 38.18  ? 201 ALA A C   1 
ATOM   1417 O O   . ALA A 1 175 ? 146.342 151.168 130.439 1.00 47.64  ? 201 ALA A O   1 
ATOM   1418 C CB  . ALA A 1 175 ? 147.069 152.278 127.424 1.00 35.47  ? 201 ALA A CB  1 
ATOM   1419 N N   . VAL A 1 176 ? 145.397 149.950 128.800 1.00 31.87  ? 202 VAL A N   1 
ATOM   1420 C CA  . VAL A 1 176 ? 144.258 149.573 129.632 1.00 34.06  ? 202 VAL A CA  1 
ATOM   1421 C C   . VAL A 1 176 ? 144.714 148.741 130.824 1.00 41.97  ? 202 VAL A C   1 
ATOM   1422 O O   . VAL A 1 176 ? 144.283 148.971 131.961 1.00 50.65  ? 202 VAL A O   1 
ATOM   1423 C CB  . VAL A 1 176 ? 143.203 148.832 128.791 1.00 38.10  ? 202 VAL A CB  1 
ATOM   1424 C CG1 . VAL A 1 176 ? 142.140 148.227 129.686 1.00 42.52  ? 202 VAL A CG1 1 
ATOM   1425 C CG2 . VAL A 1 176 ? 142.568 149.780 127.794 1.00 38.81  ? 202 VAL A CG2 1 
ATOM   1426 N N   . LEU A 1 177 ? 145.595 147.767 130.590 1.00 37.52  ? 203 LEU A N   1 
ATOM   1427 C CA  . LEU A 1 177 ? 146.067 146.920 131.681 1.00 36.86  ? 203 LEU A CA  1 
ATOM   1428 C C   . LEU A 1 177 ? 146.897 147.712 132.685 1.00 40.25  ? 203 LEU A C   1 
ATOM   1429 O O   . LEU A 1 177 ? 146.734 147.549 133.904 1.00 50.94  ? 203 LEU A O   1 
ATOM   1430 C CB  . LEU A 1 177 ? 146.870 145.749 131.119 1.00 38.99  ? 203 LEU A CB  1 
ATOM   1431 C CG  . LEU A 1 177 ? 146.082 144.753 130.268 1.00 39.96  ? 203 LEU A CG  1 
ATOM   1432 C CD1 . LEU A 1 177 ? 147.016 143.901 129.438 1.00 37.75  ? 203 LEU A CD1 1 
ATOM   1433 C CD2 . LEU A 1 177 ? 145.213 143.878 131.150 1.00 40.94  ? 203 LEU A CD2 1 
ATOM   1434 N N   . ARG A 1 178 ? 147.791 148.576 132.194 1.00 35.07  ? 204 ARG A N   1 
ATOM   1435 C CA  . ARG A 1 178 ? 148.578 149.405 133.100 1.00 39.18  ? 204 ARG A CA  1 
ATOM   1436 C C   . ARG A 1 178 ? 147.681 150.320 133.921 1.00 47.09  ? 204 ARG A C   1 
ATOM   1437 O O   . ARG A 1 178 ? 147.890 150.486 135.129 1.00 55.75  ? 204 ARG A O   1 
ATOM   1438 C CB  . ARG A 1 178 ? 149.600 150.220 132.312 1.00 39.64  ? 204 ARG A CB  1 
ATOM   1439 C CG  . ARG A 1 178 ? 150.670 149.387 131.636 1.00 36.14  ? 204 ARG A CG  1 
ATOM   1440 C CD  . ARG A 1 178 ? 151.513 150.237 130.709 1.00 36.28  ? 204 ARG A CD  1 
ATOM   1441 N NE  . ARG A 1 178 ? 152.539 149.454 130.034 1.00 32.58  ? 204 ARG A NE  1 
ATOM   1442 C CZ  . ARG A 1 178 ? 153.302 149.910 129.051 1.00 38.29  ? 204 ARG A CZ  1 
ATOM   1443 N NH1 . ARG A 1 178 ? 153.177 151.144 128.596 1.00 43.32  ? 204 ARG A NH1 1 
ATOM   1444 N NH2 . ARG A 1 178 ? 154.211 149.106 128.509 1.00 39.77  ? 204 ARG A NH2 1 
ATOM   1445 N N   . GLY A 1 179 ? 146.667 150.910 133.285 1.00 40.93  ? 205 GLY A N   1 
ATOM   1446 C CA  . GLY A 1 179 ? 145.747 151.763 134.013 1.00 39.63  ? 205 GLY A CA  1 
ATOM   1447 C C   . GLY A 1 179 ? 144.942 151.001 135.044 1.00 41.83  ? 205 GLY A C   1 
ATOM   1448 O O   . GLY A 1 179 ? 144.680 151.511 136.132 1.00 50.77  ? 205 GLY A O   1 
ATOM   1449 N N   . GLN A 1 180 ? 144.550 149.767 134.725 1.00 35.90  ? 206 GLN A N   1 
ATOM   1450 C CA  . GLN A 1 180 ? 143.807 148.957 135.686 1.00 41.51  ? 206 GLN A CA  1 
ATOM   1451 C C   . GLN A 1 180 ? 144.657 148.644 136.912 1.00 44.13  ? 206 GLN A C   1 
ATOM   1452 O O   . GLN A 1 180 ? 144.197 148.786 138.053 1.00 48.42  ? 206 GLN A O   1 
ATOM   1453 C CB  . GLN A 1 180 ? 143.323 147.670 135.020 1.00 36.26  ? 206 GLN A CB  1 
ATOM   1454 C CG  . GLN A 1 180 ? 142.541 146.750 135.937 1.00 45.73  ? 206 GLN A CG  1 
ATOM   1455 C CD  . GLN A 1 180 ? 141.199 147.324 136.334 1.00 52.00  ? 206 GLN A CD  1 
ATOM   1456 O OE1 . GLN A 1 180 ? 140.637 148.163 135.632 1.00 46.84  ? 206 GLN A OE1 1 
ATOM   1457 N NE2 . GLN A 1 180 ? 140.676 146.876 137.469 1.00 52.79  ? 206 GLN A NE2 1 
ATOM   1458 N N   . ILE A 1 181 ? 145.907 148.225 136.696 1.00 42.44  ? 207 ILE A N   1 
ATOM   1459 C CA  . ILE A 1 181 ? 146.777 147.908 137.827 1.00 41.42  ? 207 ILE A CA  1 
ATOM   1460 C C   . ILE A 1 181 ? 147.064 149.159 138.654 1.00 41.10  ? 207 ILE A C   1 
ATOM   1461 O O   . ILE A 1 181 ? 147.053 149.122 139.896 1.00 44.94  ? 207 ILE A O   1 
ATOM   1462 C CB  . ILE A 1 181 ? 148.073 147.241 137.331 1.00 38.26  ? 207 ILE A CB  1 
ATOM   1463 C CG1 . ILE A 1 181 ? 147.752 146.001 136.496 1.00 33.25  ? 207 ILE A CG1 1 
ATOM   1464 C CG2 . ILE A 1 181 ? 148.957 146.865 138.501 1.00 42.73  ? 207 ILE A CG2 1 
ATOM   1465 C CD1 . ILE A 1 181 ? 146.965 144.950 137.236 1.00 35.30  ? 207 ILE A CD1 1 
ATOM   1466 N N   . PHE A 1 182 ? 147.313 150.288 137.983 1.00 41.85  ? 208 PHE A N   1 
ATOM   1467 C CA  . PHE A 1 182 ? 147.569 151.534 138.697 1.00 42.05  ? 208 PHE A CA  1 
ATOM   1468 C C   . PHE A 1 182 ? 146.348 151.979 139.487 1.00 46.13  ? 208 PHE A C   1 
ATOM   1469 O O   . PHE A 1 182 ? 146.480 152.483 140.607 1.00 52.12  ? 208 PHE A O   1 
ATOM   1470 C CB  . PHE A 1 182 ? 147.997 152.622 137.714 1.00 43.03  ? 208 PHE A CB  1 
ATOM   1471 C CG  . PHE A 1 182 ? 148.115 153.987 138.332 1.00 45.04  ? 208 PHE A CG  1 
ATOM   1472 C CD1 . PHE A 1 182 ? 149.264 154.358 139.004 1.00 43.36  ? 208 PHE A CD1 1 
ATOM   1473 C CD2 . PHE A 1 182 ? 147.079 154.900 138.233 1.00 47.31  ? 208 PHE A CD2 1 
ATOM   1474 C CE1 . PHE A 1 182 ? 149.377 155.610 139.570 1.00 46.09  ? 208 PHE A CE1 1 
ATOM   1475 C CE2 . PHE A 1 182 ? 147.186 156.153 138.800 1.00 46.93  ? 208 PHE A CE2 1 
ATOM   1476 C CZ  . PHE A 1 182 ? 148.337 156.508 139.468 1.00 48.92  ? 208 PHE A CZ  1 
ATOM   1477 N N   . ILE A 1 183 ? 145.152 151.817 138.917 1.00 44.17  ? 209 ILE A N   1 
ATOM   1478 C CA  . ILE A 1 183 ? 143.933 152.161 139.636 1.00 40.95  ? 209 ILE A CA  1 
ATOM   1479 C C   . ILE A 1 183 ? 143.780 151.282 140.865 1.00 39.45  ? 209 ILE A C   1 
ATOM   1480 O O   . ILE A 1 183 ? 143.430 151.767 141.943 1.00 47.64  ? 209 ILE A O   1 
ATOM   1481 C CB  . ILE A 1 183 ? 142.711 152.057 138.704 1.00 39.97  ? 209 ILE A CB  1 
ATOM   1482 C CG1 . ILE A 1 183 ? 142.632 153.281 137.792 1.00 40.43  ? 209 ILE A CG1 1 
ATOM   1483 C CG2 . ILE A 1 183 ? 141.430 151.913 139.503 1.00 40.28  ? 209 ILE A CG2 1 
ATOM   1484 C CD1 . ILE A 1 183 ? 141.476 153.245 136.825 1.00 42.66  ? 209 ILE A CD1 1 
ATOM   1485 N N   . VAL A 1 184 ? 144.070 149.986 140.736 1.00 41.55  ? 210 VAL A N   1 
ATOM   1486 C CA  . VAL A 1 184 ? 143.978 149.099 141.894 1.00 45.32  ? 210 VAL A CA  1 
ATOM   1487 C C   . VAL A 1 184 ? 144.894 149.590 143.007 1.00 45.18  ? 210 VAL A C   1 
ATOM   1488 O O   . VAL A 1 184 ? 144.455 149.812 144.145 1.00 48.62  ? 210 VAL A O   1 
ATOM   1489 C CB  . VAL A 1 184 ? 144.306 147.650 141.493 1.00 42.33  ? 210 VAL A CB  1 
ATOM   1490 C CG1 . VAL A 1 184 ? 144.488 146.792 142.728 1.00 43.17  ? 210 VAL A CG1 1 
ATOM   1491 C CG2 . VAL A 1 184 ? 143.207 147.081 140.612 1.00 43.36  ? 210 VAL A CG2 1 
ATOM   1492 N N   . TYR A 1 185 ? 146.165 149.837 142.677 1.00 42.26  ? 211 TYR A N   1 
ATOM   1493 C CA  . TYR A 1 185 ? 147.121 150.262 143.698 1.00 37.52  ? 211 TYR A CA  1 
ATOM   1494 C C   . TYR A 1 185 ? 146.714 151.594 144.323 1.00 44.27  ? 211 TYR A C   1 
ATOM   1495 O O   . TYR A 1 185 ? 146.661 151.729 145.554 1.00 52.71  ? 211 TYR A O   1 
ATOM   1496 C CB  . TYR A 1 185 ? 148.525 150.369 143.102 1.00 44.18  ? 211 TYR A CB  1 
ATOM   1497 C CG  . TYR A 1 185 ? 149.274 149.060 142.991 1.00 45.18  ? 211 TYR A CG  1 
ATOM   1498 C CD1 . TYR A 1 185 ? 149.598 148.326 144.121 1.00 42.85  ? 211 TYR A CD1 1 
ATOM   1499 C CD2 . TYR A 1 185 ? 149.683 148.576 141.758 1.00 42.78  ? 211 TYR A CD2 1 
ATOM   1500 C CE1 . TYR A 1 185 ? 150.289 147.138 144.024 1.00 41.09  ? 211 TYR A CE1 1 
ATOM   1501 C CE2 . TYR A 1 185 ? 150.377 147.389 141.654 1.00 39.23  ? 211 TYR A CE2 1 
ATOM   1502 C CZ  . TYR A 1 185 ? 150.675 146.675 142.789 1.00 40.73  ? 211 TYR A CZ  1 
ATOM   1503 O OH  . TYR A 1 185 ? 151.366 145.491 142.686 1.00 50.08  ? 211 TYR A OH  1 
ATOM   1504 N N   . PHE A 1 186 ? 146.397 152.585 143.487 1.00 41.35  ? 212 PHE A N   1 
ATOM   1505 C CA  . PHE A 1 186 ? 146.154 153.931 143.991 1.00 33.95  ? 212 PHE A CA  1 
ATOM   1506 C C   . PHE A 1 186 ? 144.850 154.013 144.772 1.00 38.82  ? 212 PHE A C   1 
ATOM   1507 O O   . PHE A 1 186 ? 144.781 154.703 145.795 1.00 46.31  ? 212 PHE A O   1 
ATOM   1508 C CB  . PHE A 1 186 ? 146.151 154.928 142.835 1.00 35.36  ? 212 PHE A CB  1 
ATOM   1509 C CG  . PHE A 1 186 ? 146.122 156.360 143.273 1.00 38.98  ? 212 PHE A CG  1 
ATOM   1510 C CD1 . PHE A 1 186 ? 147.254 156.959 143.792 1.00 37.81  ? 212 PHE A CD1 1 
ATOM   1511 C CD2 . PHE A 1 186 ? 144.966 157.109 143.159 1.00 46.36  ? 212 PHE A CD2 1 
ATOM   1512 C CE1 . PHE A 1 186 ? 147.233 158.275 144.196 1.00 41.78  ? 212 PHE A CE1 1 
ATOM   1513 C CE2 . PHE A 1 186 ? 144.940 158.429 143.561 1.00 48.44  ? 212 PHE A CE2 1 
ATOM   1514 C CZ  . PHE A 1 186 ? 146.076 159.011 144.080 1.00 48.20  ? 212 PHE A CZ  1 
ATOM   1515 N N   . ILE A 1 187 ? 143.802 153.327 144.312 1.00 38.72  ? 213 ILE A N   1 
ATOM   1516 C CA  . ILE A 1 187 ? 142.538 153.362 145.034 1.00 36.01  ? 213 ILE A CA  1 
ATOM   1517 C C   . ILE A 1 187 ? 142.650 152.594 146.342 1.00 38.12  ? 213 ILE A C   1 
ATOM   1518 O O   . ILE A 1 187 ? 142.075 153.001 147.356 1.00 46.77  ? 213 ILE A O   1 
ATOM   1519 C CB  . ILE A 1 187 ? 141.391 152.838 144.153 1.00 42.90  ? 213 ILE A CB  1 
ATOM   1520 C CG1 . ILE A 1 187 ? 141.212 153.738 142.931 1.00 43.14  ? 213 ILE A CG1 1 
ATOM   1521 C CG2 . ILE A 1 187 ? 140.095 152.799 144.938 1.00 42.64  ? 213 ILE A CG2 1 
ATOM   1522 C CD1 . ILE A 1 187 ? 140.848 155.162 143.273 1.00 42.09  ? 213 ILE A CD1 1 
ATOM   1523 N N   . ALA A 1 188 ? 143.408 151.491 146.363 1.00 37.99  ? 214 ALA A N   1 
ATOM   1524 C CA  . ALA A 1 188 ? 143.646 150.822 147.637 1.00 39.25  ? 214 ALA A CA  1 
ATOM   1525 C C   . ALA A 1 188 ? 144.366 151.748 148.607 1.00 37.53  ? 214 ALA A C   1 
ATOM   1526 O O   . ALA A 1 188 ? 143.990 151.848 149.784 1.00 46.12  ? 214 ALA A O   1 
ATOM   1527 C CB  . ALA A 1 188 ? 144.445 149.539 147.420 1.00 41.26  ? 214 ALA A CB  1 
ATOM   1528 N N   . GLY A 1 189 ? 145.380 152.465 148.120 1.00 39.27  ? 215 GLY A N   1 
ATOM   1529 C CA  . GLY A 1 189 ? 146.093 153.392 148.983 1.00 42.80  ? 215 GLY A CA  1 
ATOM   1530 C C   . GLY A 1 189 ? 145.214 154.512 149.508 1.00 43.07  ? 215 GLY A C   1 
ATOM   1531 O O   . GLY A 1 189 ? 145.250 154.833 150.698 1.00 53.81  ? 215 GLY A O   1 
ATOM   1532 N N   . VAL A 1 190 ? 144.406 155.115 148.634 1.00 32.29  ? 216 VAL A N   1 
ATOM   1533 C CA  . VAL A 1 190 ? 143.581 156.245 149.051 1.00 31.23  ? 216 VAL A CA  1 
ATOM   1534 C C   . VAL A 1 190 ? 142.389 155.804 149.896 1.00 42.24  ? 216 VAL A C   1 
ATOM   1535 O O   . VAL A 1 190 ? 141.875 156.600 150.691 1.00 49.91  ? 216 VAL A O   1 
ATOM   1536 C CB  . VAL A 1 190 ? 143.120 157.056 147.827 1.00 34.25  ? 216 VAL A CB  1 
ATOM   1537 C CG1 . VAL A 1 190 ? 142.087 156.288 147.029 1.00 42.44  ? 216 VAL A CG1 1 
ATOM   1538 C CG2 . VAL A 1 190 ? 142.580 158.412 148.246 1.00 35.08  ? 216 VAL A CG2 1 
ATOM   1539 N N   . LYS A 1 191 ? 141.942 154.552 149.763 1.00 46.10  ? 217 LYS A N   1 
ATOM   1540 C CA  . LYS A 1 191 ? 140.932 154.022 150.669 1.00 42.66  ? 217 LYS A CA  1 
ATOM   1541 C C   . LYS A 1 191 ? 141.530 153.662 152.020 1.00 43.73  ? 217 LYS A C   1 
ATOM   1542 O O   . LYS A 1 191 ? 140.821 153.680 153.031 1.00 53.17  ? 217 LYS A O   1 
ATOM   1543 C CB  . LYS A 1 191 ? 140.254 152.797 150.055 1.00 41.16  ? 217 LYS A CB  1 
ATOM   1544 C CG  . LYS A 1 191 ? 139.315 153.104 148.901 1.00 40.00  ? 217 LYS A CG  1 
ATOM   1545 C CD  . LYS A 1 191 ? 138.051 153.790 149.374 1.00 40.07  ? 217 LYS A CD  1 
ATOM   1546 C CE  . LYS A 1 191 ? 137.081 154.002 148.227 1.00 50.11  ? 217 LYS A CE  1 
ATOM   1547 N NZ  . LYS A 1 191 ? 135.808 154.617 148.689 1.00 52.12  ? 217 LYS A NZ  1 
ATOM   1548 N N   . LYS A 1 192 ? 142.821 153.338 152.059 1.00 39.21  ? 218 LYS A N   1 
ATOM   1549 C CA  . LYS A 1 192 ? 143.492 153.078 153.324 1.00 33.66  ? 218 LYS A CA  1 
ATOM   1550 C C   . LYS A 1 192 ? 143.899 154.355 154.050 1.00 40.81  ? 218 LYS A C   1 
ATOM   1551 O O   . LYS A 1 192 ? 144.526 154.272 155.110 1.00 53.05  ? 218 LYS A O   1 
ATOM   1552 C CB  . LYS A 1 192 ? 144.715 152.187 153.102 1.00 42.37  ? 218 LYS A CB  1 
ATOM   1553 C CG  . LYS A 1 192 ? 144.363 150.742 152.795 1.00 45.42  ? 218 LYS A CG  1 
ATOM   1554 C CD  . LYS A 1 192 ? 145.600 149.903 152.545 1.00 43.74  ? 218 LYS A CD  1 
ATOM   1555 C CE  . LYS A 1 192 ? 145.230 148.458 152.277 1.00 43.75  ? 218 LYS A CE  1 
ATOM   1556 N NZ  . LYS A 1 192 ? 144.313 148.328 151.113 1.00 47.09  ? 218 LYS A NZ  1 
ATOM   1557 N N   . LEU A 1 193 ? 143.560 155.524 153.510 1.00 45.16  ? 219 LEU A N   1 
ATOM   1558 C CA  . LEU A 1 193 ? 143.739 156.790 154.222 1.00 47.50  ? 219 LEU A CA  1 
ATOM   1559 C C   . LEU A 1 193 ? 142.540 157.050 155.135 1.00 48.29  ? 219 LEU A C   1 
ATOM   1560 O O   . LEU A 1 193 ? 141.841 158.057 155.039 1.00 50.25  ? 219 LEU A O   1 
ATOM   1561 C CB  . LEU A 1 193 ? 143.942 157.934 153.235 1.00 44.98  ? 219 LEU A CB  1 
ATOM   1562 C CG  . LEU A 1 193 ? 145.371 158.250 152.794 1.00 44.23  ? 219 LEU A CG  1 
ATOM   1563 C CD1 . LEU A 1 193 ? 145.369 159.354 151.752 1.00 47.14  ? 219 LEU A CD1 1 
ATOM   1564 C CD2 . LEU A 1 193 ? 146.217 158.649 153.988 1.00 47.62  ? 219 LEU A CD2 1 
ATOM   1565 N N   . ASP A 1 194 ? 142.318 156.105 156.040 1.00 57.89  ? 220 ASP A N   1 
ATOM   1566 C CA  . ASP A 1 194 ? 141.201 156.131 156.968 1.00 54.20  ? 220 ASP A CA  1 
ATOM   1567 C C   . ASP A 1 194 ? 141.718 156.317 158.388 1.00 61.02  ? 220 ASP A C   1 
ATOM   1568 O O   . ASP A 1 194 ? 142.887 156.058 158.687 1.00 67.39  ? 220 ASP A O   1 
ATOM   1569 C CB  . ASP A 1 194 ? 140.379 154.841 156.866 1.00 53.69  ? 220 ASP A CB  1 
ATOM   1570 C CG  . ASP A 1 194 ? 139.030 154.951 157.544 1.00 64.91  ? 220 ASP A CG  1 
ATOM   1571 O OD1 . ASP A 1 194 ? 138.690 156.050 158.031 1.00 67.14  ? 220 ASP A OD1 1 
ATOM   1572 O OD2 . ASP A 1 194 ? 138.306 153.935 157.590 1.00 67.13  ? 220 ASP A OD2 1 
ATOM   1573 N N   . ALA A 1 195 ? 140.828 156.777 159.268 1.00 54.24  ? 221 ALA A N   1 
ATOM   1574 C CA  . ALA A 1 195 ? 141.216 157.017 160.651 1.00 52.20  ? 221 ALA A CA  1 
ATOM   1575 C C   . ALA A 1 195 ? 141.525 155.728 161.399 1.00 54.63  ? 221 ALA A C   1 
ATOM   1576 O O   . ALA A 1 195 ? 142.230 155.770 162.412 1.00 60.20  ? 221 ALA A O   1 
ATOM   1577 C CB  . ALA A 1 195 ? 140.118 157.791 161.380 1.00 56.02  ? 221 ALA A CB  1 
ATOM   1578 N N   . ASP A 1 196 ? 141.019 154.590 160.930 1.00 54.20  ? 222 ASP A N   1 
ATOM   1579 C CA  . ASP A 1 196 ? 141.273 153.313 161.579 1.00 52.55  ? 222 ASP A CA  1 
ATOM   1580 C C   . ASP A 1 196 ? 142.502 152.599 161.036 1.00 56.39  ? 222 ASP A C   1 
ATOM   1581 O O   . ASP A 1 196 ? 142.899 151.573 161.598 1.00 64.68  ? 222 ASP A O   1 
ATOM   1582 C CB  . ASP A 1 196 ? 140.053 152.397 161.439 1.00 55.16  ? 222 ASP A CB  1 
ATOM   1583 C CG  . ASP A 1 196 ? 138.823 152.955 162.125 1.00 63.70  ? 222 ASP A CG  1 
ATOM   1584 O OD1 . ASP A 1 196 ? 138.910 154.062 162.697 1.00 67.19  ? 222 ASP A OD1 1 
ATOM   1585 O OD2 . ASP A 1 196 ? 137.769 152.286 162.093 1.00 63.77  ? 222 ASP A OD2 1 
ATOM   1586 N N   . TRP A 1 197 ? 143.110 153.106 159.967 1.00 54.29  ? 223 TRP A N   1 
ATOM   1587 C CA  . TRP A 1 197 ? 144.295 152.493 159.378 1.00 52.47  ? 223 TRP A CA  1 
ATOM   1588 C C   . TRP A 1 197 ? 145.569 153.278 159.636 1.00 55.10  ? 223 TRP A C   1 
ATOM   1589 O O   . TRP A 1 197 ? 146.622 152.676 159.852 1.00 63.93  ? 223 TRP A O   1 
ATOM   1590 C CB  . TRP A 1 197 ? 144.108 152.321 157.867 1.00 51.11  ? 223 TRP A CB  1 
ATOM   1591 C CG  . TRP A 1 197 ? 145.260 151.643 157.194 1.00 50.28  ? 223 TRP A CG  1 
ATOM   1592 C CD1 . TRP A 1 197 ? 146.334 152.244 156.610 1.00 52.27  ? 223 TRP A CD1 1 
ATOM   1593 C CD2 . TRP A 1 197 ? 145.453 150.234 157.033 1.00 48.78  ? 223 TRP A CD2 1 
ATOM   1594 N NE1 . TRP A 1 197 ? 147.184 151.298 156.095 1.00 52.93  ? 223 TRP A NE1 1 
ATOM   1595 C CE2 . TRP A 1 197 ? 146.665 150.055 156.342 1.00 51.85  ? 223 TRP A CE2 1 
ATOM   1596 C CE3 . TRP A 1 197 ? 144.718 149.106 157.406 1.00 54.01  ? 223 TRP A CE3 1 
ATOM   1597 C CZ2 . TRP A 1 197 ? 147.159 148.796 156.017 1.00 55.85  ? 223 TRP A CZ2 1 
ATOM   1598 C CZ3 . TRP A 1 197 ? 145.211 147.859 157.083 1.00 55.03  ? 223 TRP A CZ3 1 
ATOM   1599 C CH2 . TRP A 1 197 ? 146.418 147.713 156.396 1.00 54.62  ? 223 TRP A CH2 1 
ATOM   1600 N N   . VAL A 1 198 ? 145.502 154.612 159.622 1.00 50.98  ? 224 VAL A N   1 
ATOM   1601 C CA  . VAL A 1 198 ? 146.678 155.423 159.926 1.00 50.14  ? 224 VAL A CA  1 
ATOM   1602 C C   . VAL A 1 198 ? 147.002 155.449 161.409 1.00 55.66  ? 224 VAL A C   1 
ATOM   1603 O O   . VAL A 1 198 ? 148.068 155.947 161.791 1.00 58.27  ? 224 VAL A O   1 
ATOM   1604 C CB  . VAL A 1 198 ? 146.497 156.870 159.430 1.00 49.72  ? 224 VAL A CB  1 
ATOM   1605 C CG1 . VAL A 1 198 ? 146.141 156.883 157.956 1.00 53.39  ? 224 VAL A CG1 1 
ATOM   1606 C CG2 . VAL A 1 198 ? 145.433 157.582 160.247 1.00 53.57  ? 224 VAL A CG2 1 
ATOM   1607 N N   . GLU A 1 199 ? 146.114 154.930 162.257 1.00 60.72  ? 225 GLU A N   1 
ATOM   1608 C CA  . GLU A 1 199 ? 146.333 154.906 163.696 1.00 60.64  ? 225 GLU A CA  1 
ATOM   1609 C C   . GLU A 1 199 ? 146.691 153.524 164.227 1.00 61.86  ? 225 GLU A C   1 
ATOM   1610 O O   . GLU A 1 199 ? 147.030 153.404 165.409 1.00 66.71  ? 225 GLU A O   1 
ATOM   1611 C CB  . GLU A 1 199 ? 145.091 155.432 164.425 1.00 56.99  ? 225 GLU A CB  1 
ATOM   1612 C CG  . GLU A 1 199 ? 144.764 156.881 164.101 1.00 60.51  ? 225 GLU A CG  1 
ATOM   1613 C CD  . GLU A 1 199 ? 143.475 157.351 164.743 1.00 63.01  ? 225 GLU A CD  1 
ATOM   1614 O OE1 . GLU A 1 199 ? 142.747 156.508 165.306 1.00 60.94  ? 225 GLU A OE1 1 
ATOM   1615 O OE2 . GLU A 1 199 ? 143.190 158.565 164.685 1.00 64.10  ? 225 GLU A OE2 1 
ATOM   1616 N N   . GLY A 1 200 ? 146.626 152.488 163.397 1.00 58.24  ? 226 GLY A N   1 
ATOM   1617 C CA  . GLY A 1 200 ? 147.063 151.169 163.805 1.00 57.02  ? 226 GLY A CA  1 
ATOM   1618 C C   . GLY A 1 200 ? 145.998 150.268 164.383 1.00 63.68  ? 226 GLY A C   1 
ATOM   1619 O O   . GLY A 1 200 ? 146.340 149.255 165.003 1.00 64.72  ? 226 GLY A O   1 
ATOM   1620 N N   . TYR A 1 201 ? 144.718 150.596 164.207 1.00 66.60  ? 227 TYR A N   1 
ATOM   1621 C CA  . TYR A 1 201 ? 143.660 149.768 164.777 1.00 59.52  ? 227 TYR A CA  1 
ATOM   1622 C C   . TYR A 1 201 ? 143.379 148.545 163.912 1.00 60.50  ? 227 TYR A C   1 
ATOM   1623 O O   . TYR A 1 201 ? 143.352 147.416 164.413 1.00 65.61  ? 227 TYR A O   1 
ATOM   1624 C CB  . TYR A 1 201 ? 142.388 150.594 164.966 1.00 59.32  ? 227 TYR A CB  1 
ATOM   1625 C CG  . TYR A 1 201 ? 142.471 151.590 166.097 1.00 62.07  ? 227 TYR A CG  1 
ATOM   1626 C CD1 . TYR A 1 201 ? 142.113 151.232 167.388 1.00 61.24  ? 227 TYR A CD1 1 
ATOM   1627 C CD2 . TYR A 1 201 ? 142.904 152.889 165.875 1.00 66.39  ? 227 TYR A CD2 1 
ATOM   1628 C CE1 . TYR A 1 201 ? 142.185 152.137 168.426 1.00 65.15  ? 227 TYR A CE1 1 
ATOM   1629 C CE2 . TYR A 1 201 ? 142.980 153.803 166.908 1.00 66.69  ? 227 TYR A CE2 1 
ATOM   1630 C CZ  . TYR A 1 201 ? 142.619 153.421 168.182 1.00 68.18  ? 227 TYR A CZ  1 
ATOM   1631 O OH  . TYR A 1 201 ? 142.692 154.326 169.216 1.00 67.31  ? 227 TYR A OH  1 
ATOM   1632 N N   . SER A 1 202 ? 143.167 148.750 162.616 1.00 56.60  ? 228 SER A N   1 
ATOM   1633 C CA  . SER A 1 202 ? 142.865 147.640 161.723 1.00 54.91  ? 228 SER A CA  1 
ATOM   1634 C C   . SER A 1 202 ? 144.099 146.773 161.523 1.00 63.40  ? 228 SER A C   1 
ATOM   1635 O O   . SER A 1 202 ? 145.197 147.286 161.285 1.00 72.00  ? 228 SER A O   1 
ATOM   1636 C CB  . SER A 1 202 ? 142.363 148.163 160.380 1.00 58.02  ? 228 SER A CB  1 
ATOM   1637 O OG  . SER A 1 202 ? 141.195 148.947 160.545 1.00 66.76  ? 228 SER A OG  1 
ATOM   1638 N N   . MET A 1 203 ? 143.915 145.455 161.622 1.00 71.47  ? 229 MET A N   1 
ATOM   1639 C CA  . MET A 1 203 ? 145.001 144.487 161.459 1.00 71.19  ? 229 MET A CA  1 
ATOM   1640 C C   . MET A 1 203 ? 146.130 144.757 162.453 1.00 69.93  ? 229 MET A C   1 
ATOM   1641 O O   . MET A 1 203 ? 147.307 144.820 162.095 1.00 73.48  ? 229 MET A O   1 
ATOM   1642 C CB  . MET A 1 203 ? 145.517 144.484 160.019 1.00 73.72  ? 229 MET A CB  1 
ATOM   1643 C CG  . MET A 1 203 ? 145.522 143.119 159.359 1.00 75.36  ? 229 MET A CG  1 
ATOM   1644 S SD  . MET A 1 203 ? 145.689 143.222 157.567 1.00 87.68  ? 229 MET A SD  1 
ATOM   1645 C CE  . MET A 1 203 ? 147.157 144.236 157.419 1.00 75.45  ? 229 MET A CE  1 
ATOM   1646 N N   . GLU A 1 204 ? 145.753 144.924 163.722 1.00 71.72  ? 230 GLU A N   1 
ATOM   1647 C CA  . GLU A 1 204 ? 146.713 145.239 164.773 1.00 73.47  ? 230 GLU A CA  1 
ATOM   1648 C C   . GLU A 1 204 ? 147.488 144.020 165.259 1.00 75.33  ? 230 GLU A C   1 
ATOM   1649 O O   . GLU A 1 204 ? 148.595 144.176 165.784 1.00 77.68  ? 230 GLU A O   1 
ATOM   1650 C CB  . GLU A 1 204 ? 145.990 145.892 165.954 1.00 76.47  ? 230 GLU A CB  1 
ATOM   1651 C CG  . GLU A 1 204 ? 146.907 146.529 166.986 1.00 80.27  ? 230 GLU A CG  1 
ATOM   1652 C CD  . GLU A 1 204 ? 146.143 147.127 168.151 1.00 82.76  ? 230 GLU A CD  1 
ATOM   1653 O OE1 . GLU A 1 204 ? 144.904 146.974 168.192 1.00 83.60  ? 230 GLU A OE1 1 
ATOM   1654 O OE2 . GLU A 1 204 ? 146.781 147.751 169.025 1.00 80.72  ? 230 GLU A OE2 1 
ATOM   1655 N N   . TYR A 1 205 ? 146.946 142.816 165.086 1.00 81.68  ? 231 TYR A N   1 
ATOM   1656 C CA  . TYR A 1 205 ? 147.547 141.603 165.623 1.00 82.12  ? 231 TYR A CA  1 
ATOM   1657 C C   . TYR A 1 205 ? 148.398 140.866 164.597 1.00 81.90  ? 231 TYR A C   1 
ATOM   1658 O O   . TYR A 1 205 ? 148.743 139.699 164.811 1.00 87.70  ? 231 TYR A O   1 
ATOM   1659 C CB  . TYR A 1 205 ? 146.461 140.675 166.169 1.00 83.52  ? 231 TYR A CB  1 
ATOM   1660 C CG  . TYR A 1 205 ? 145.687 141.247 167.336 1.00 89.19  ? 231 TYR A CG  1 
ATOM   1661 C CD1 . TYR A 1 205 ? 146.272 142.164 168.200 1.00 89.89  ? 231 TYR A CD1 1 
ATOM   1662 C CD2 . TYR A 1 205 ? 144.371 140.870 167.573 1.00 87.85  ? 231 TYR A CD2 1 
ATOM   1663 C CE1 . TYR A 1 205 ? 145.568 142.688 169.268 1.00 88.81  ? 231 TYR A CE1 1 
ATOM   1664 C CE2 . TYR A 1 205 ? 143.660 141.390 168.638 1.00 88.22  ? 231 TYR A CE2 1 
ATOM   1665 C CZ  . TYR A 1 205 ? 144.263 142.299 169.482 1.00 89.41  ? 231 TYR A CZ  1 
ATOM   1666 O OH  . TYR A 1 205 ? 143.559 142.819 170.543 1.00 86.90  ? 231 TYR A OH  1 
ATOM   1667 N N   . LEU A 1 206 ? 148.746 141.518 163.492 1.00 63.67  ? 232 LEU A N   1 
ATOM   1668 C CA  . LEU A 1 206 ? 149.514 140.874 162.436 1.00 62.44  ? 232 LEU A CA  1 
ATOM   1669 C C   . LEU A 1 206 ? 151.018 140.943 162.665 1.00 63.16  ? 232 LEU A C   1 
ATOM   1670 O O   . LEU A 1 206 ? 151.772 140.312 161.917 1.00 66.04  ? 232 LEU A O   1 
ATOM   1671 C CB  . LEU A 1 206 ? 149.172 141.503 161.081 1.00 64.21  ? 232 LEU A CB  1 
ATOM   1672 C CG  . LEU A 1 206 ? 149.394 140.628 159.847 1.00 64.27  ? 232 LEU A CG  1 
ATOM   1673 C CD1 . LEU A 1 206 ? 148.439 139.449 159.860 1.00 63.31  ? 232 LEU A CD1 1 
ATOM   1674 C CD2 . LEU A 1 206 ? 149.236 141.439 158.576 1.00 64.71  ? 232 LEU A CD2 1 
ATOM   1675 N N   . SER A 1 207 ? 151.471 141.679 163.676 1.00 67.01  ? 233 SER A N   1 
ATOM   1676 C CA  . SER A 1 207 ? 152.895 141.799 163.956 1.00 66.75  ? 233 SER A CA  1 
ATOM   1677 C C   . SER A 1 207 ? 153.442 140.637 164.773 1.00 67.94  ? 233 SER A C   1 
ATOM   1678 O O   . SER A 1 207 ? 154.657 140.571 164.986 1.00 72.26  ? 233 SER A O   1 
ATOM   1679 C CB  . SER A 1 207 ? 153.176 143.114 164.686 1.00 67.78  ? 233 SER A CB  1 
ATOM   1680 O OG  . SER A 1 207 ? 154.551 143.236 165.003 1.00 71.27  ? 233 SER A OG  1 
ATOM   1681 N N   . ARG A 1 208 ? 152.588 139.726 165.231 1.00 69.74  ? 234 ARG A N   1 
ATOM   1682 C CA  . ARG A 1 208 ? 153.026 138.575 166.006 1.00 69.71  ? 234 ARG A CA  1 
ATOM   1683 C C   . ARG A 1 208 ? 153.420 137.391 165.134 1.00 74.54  ? 234 ARG A C   1 
ATOM   1684 O O   . ARG A 1 208 ? 153.903 136.385 165.663 1.00 79.60  ? 234 ARG A O   1 
ATOM   1685 C CB  . ARG A 1 208 ? 151.928 138.150 166.985 1.00 74.92  ? 234 ARG A CB  1 
ATOM   1686 C CG  . ARG A 1 208 ? 151.495 139.247 167.941 1.00 77.96  ? 234 ARG A CG  1 
ATOM   1687 C CD  . ARG A 1 208 ? 150.379 138.775 168.858 1.00 77.31  ? 234 ARG A CD  1 
ATOM   1688 N NE  . ARG A 1 208 ? 149.910 139.841 169.735 1.00 79.32  ? 234 ARG A NE  1 
ATOM   1689 C CZ  . ARG A 1 208 ? 148.922 139.712 170.610 1.00 80.66  ? 234 ARG A CZ  1 
ATOM   1690 N NH1 . ARG A 1 208 ? 148.272 138.569 170.755 1.00 79.90  ? 234 ARG A NH1 1 
ATOM   1691 N NH2 . ARG A 1 208 ? 148.577 140.756 171.358 1.00 79.27  ? 234 ARG A NH2 1 
ATOM   1692 N N   . HIS A 1 209 ? 153.225 137.484 163.822 1.00 69.83  ? 235 HIS A N   1 
ATOM   1693 C CA  . HIS A 1 209 ? 153.638 136.419 162.922 1.00 67.48  ? 235 HIS A CA  1 
ATOM   1694 C C   . HIS A 1 209 ? 155.159 136.349 162.849 1.00 67.97  ? 235 HIS A C   1 
ATOM   1695 O O   . HIS A 1 209 ? 155.860 137.342 163.061 1.00 70.32  ? 235 HIS A O   1 
ATOM   1696 C CB  . HIS A 1 209 ? 153.054 136.644 161.529 1.00 64.99  ? 235 HIS A CB  1 
ATOM   1697 C CG  . HIS A 1 209 ? 152.920 135.393 160.720 1.00 64.92  ? 235 HIS A CG  1 
ATOM   1698 N ND1 . HIS A 1 209 ? 153.945 134.892 159.948 1.00 70.08  ? 235 HIS A ND1 1 
ATOM   1699 C CD2 . HIS A 1 209 ? 151.878 134.545 160.558 1.00 67.76  ? 235 HIS A CD2 1 
ATOM   1700 C CE1 . HIS A 1 209 ? 153.541 133.787 159.347 1.00 70.52  ? 235 HIS A CE1 1 
ATOM   1701 N NE2 . HIS A 1 209 ? 152.291 133.554 159.701 1.00 69.45  ? 235 HIS A NE2 1 
ATOM   1702 N N   . TRP A 1 210 ? 155.671 135.155 162.546 1.00 67.50  ? 236 TRP A N   1 
ATOM   1703 C CA  . TRP A 1 210 ? 157.116 134.964 162.518 1.00 69.76  ? 236 TRP A CA  1 
ATOM   1704 C C   . TRP A 1 210 ? 157.771 135.629 161.315 1.00 70.49  ? 236 TRP A C   1 
ATOM   1705 O O   . TRP A 1 210 ? 158.982 135.876 161.346 1.00 75.48  ? 236 TRP A O   1 
ATOM   1706 C CB  . TRP A 1 210 ? 157.455 133.472 162.538 1.00 67.74  ? 236 TRP A CB  1 
ATOM   1707 C CG  . TRP A 1 210 ? 157.004 132.725 161.324 1.00 68.44  ? 236 TRP A CG  1 
ATOM   1708 C CD1 . TRP A 1 210 ? 155.790 132.137 161.129 1.00 70.16  ? 236 TRP A CD1 1 
ATOM   1709 C CD2 . TRP A 1 210 ? 157.768 132.472 160.139 1.00 72.68  ? 236 TRP A CD2 1 
ATOM   1710 N NE1 . TRP A 1 210 ? 155.747 131.539 159.893 1.00 71.93  ? 236 TRP A NE1 1 
ATOM   1711 C CE2 . TRP A 1 210 ? 156.950 131.730 159.266 1.00 72.93  ? 236 TRP A CE2 1 
ATOM   1712 C CE3 . TRP A 1 210 ? 159.063 132.803 159.732 1.00 74.29  ? 236 TRP A CE3 1 
ATOM   1713 C CZ2 . TRP A 1 210 ? 157.384 131.314 158.009 1.00 72.43  ? 236 TRP A CZ2 1 
ATOM   1714 C CZ3 . TRP A 1 210 ? 159.493 132.390 158.484 1.00 73.86  ? 236 TRP A CZ3 1 
ATOM   1715 C CH2 . TRP A 1 210 ? 158.655 131.653 157.638 1.00 72.91  ? 236 TRP A CH2 1 
ATOM   1716 N N   . LEU A 1 211 ? 157.005 135.936 160.265 1.00 65.05  ? 237 LEU A N   1 
ATOM   1717 C CA  . LEU A 1 211 ? 157.589 136.589 159.098 1.00 67.70  ? 237 LEU A CA  1 
ATOM   1718 C C   . LEU A 1 211 ? 158.108 137.980 159.433 1.00 68.49  ? 237 LEU A C   1 
ATOM   1719 O O   . LEU A 1 211 ? 159.038 138.466 158.780 1.00 71.01  ? 237 LEU A O   1 
ATOM   1720 C CB  . LEU A 1 211 ? 156.568 136.661 157.963 1.00 66.60  ? 237 LEU A CB  1 
ATOM   1721 C CG  . LEU A 1 211 ? 156.352 135.372 157.173 1.00 65.83  ? 237 LEU A CG  1 
ATOM   1722 C CD1 . LEU A 1 211 ? 155.283 135.565 156.115 1.00 64.74  ? 237 LEU A CD1 1 
ATOM   1723 C CD2 . LEU A 1 211 ? 157.654 134.918 156.537 1.00 66.41  ? 237 LEU A CD2 1 
ATOM   1724 N N   . PHE A 1 212 ? 157.528 138.634 160.438 1.00 63.08  ? 238 PHE A N   1 
ATOM   1725 C CA  . PHE A 1 212 ? 158.013 139.920 160.912 1.00 65.71  ? 238 PHE A CA  1 
ATOM   1726 C C   . PHE A 1 212 ? 159.069 139.777 161.999 1.00 68.34  ? 238 PHE A C   1 
ATOM   1727 O O   . PHE A 1 212 ? 159.326 140.738 162.733 1.00 72.61  ? 238 PHE A O   1 
ATOM   1728 C CB  . PHE A 1 212 ? 156.848 140.770 161.421 1.00 66.89  ? 238 PHE A CB  1 
ATOM   1729 C CG  . PHE A 1 212 ? 155.819 141.082 160.374 1.00 65.15  ? 238 PHE A CG  1 
ATOM   1730 C CD1 . PHE A 1 212 ? 155.965 142.182 159.547 1.00 64.04  ? 238 PHE A CD1 1 
ATOM   1731 C CD2 . PHE A 1 212 ? 154.704 140.281 160.221 1.00 65.22  ? 238 PHE A CD2 1 
ATOM   1732 C CE1 . PHE A 1 212 ? 155.020 142.471 158.586 1.00 64.31  ? 238 PHE A CE1 1 
ATOM   1733 C CE2 . PHE A 1 212 ? 153.756 140.566 159.261 1.00 64.56  ? 238 PHE A CE2 1 
ATOM   1734 C CZ  . PHE A 1 212 ? 153.915 141.663 158.442 1.00 65.53  ? 238 PHE A CZ  1 
ATOM   1735 N N   . SER A 1 213 ? 159.679 138.598 162.120 1.00 72.03  ? 239 SER A N   1 
ATOM   1736 C CA  . SER A 1 213 ? 160.703 138.397 163.142 1.00 71.38  ? 239 SER A CA  1 
ATOM   1737 C C   . SER A 1 213 ? 161.917 139.311 162.993 1.00 72.16  ? 239 SER A C   1 
ATOM   1738 O O   . SER A 1 213 ? 162.371 139.846 164.020 1.00 73.52  ? 239 SER A O   1 
ATOM   1739 C CB  . SER A 1 213 ? 161.124 136.922 163.167 1.00 71.68  ? 239 SER A CB  1 
ATOM   1740 O OG  . SER A 1 213 ? 161.227 136.384 161.860 1.00 77.00  ? 239 SER A OG  1 
ATOM   1741 N N   . PRO A 1 214 ? 162.497 139.527 161.804 1.00 72.00  ? 240 PRO A N   1 
ATOM   1742 C CA  . PRO A 1 214 ? 163.659 140.429 161.735 1.00 75.55  ? 240 PRO A CA  1 
ATOM   1743 C C   . PRO A 1 214 ? 163.344 141.857 162.144 1.00 78.49  ? 240 PRO A C   1 
ATOM   1744 O O   . PRO A 1 214 ? 164.196 142.511 162.758 1.00 81.85  ? 240 PRO A O   1 
ATOM   1745 C CB  . PRO A 1 214 ? 164.086 140.343 160.263 1.00 75.89  ? 240 PRO A CB  1 
ATOM   1746 C CG  . PRO A 1 214 ? 162.863 139.926 159.543 1.00 76.11  ? 240 PRO A CG  1 
ATOM   1747 C CD  . PRO A 1 214 ? 162.168 138.984 160.473 1.00 74.32  ? 240 PRO A CD  1 
ATOM   1748 N N   . PHE A 1 215 ? 162.143 142.354 161.838 1.00 79.26  ? 241 PHE A N   1 
ATOM   1749 C CA  . PHE A 1 215 ? 161.787 143.721 162.203 1.00 79.44  ? 241 PHE A CA  1 
ATOM   1750 C C   . PHE A 1 215 ? 161.822 143.929 163.710 1.00 78.96  ? 241 PHE A C   1 
ATOM   1751 O O   . PHE A 1 215 ? 162.044 145.053 164.174 1.00 82.49  ? 241 PHE A O   1 
ATOM   1752 C CB  . PHE A 1 215 ? 160.402 144.070 161.656 1.00 80.85  ? 241 PHE A CB  1 
ATOM   1753 C CG  . PHE A 1 215 ? 160.347 144.175 160.158 1.00 81.57  ? 241 PHE A CG  1 
ATOM   1754 C CD1 . PHE A 1 215 ? 160.201 143.042 159.374 1.00 80.86  ? 241 PHE A CD1 1 
ATOM   1755 C CD2 . PHE A 1 215 ? 160.438 145.407 159.534 1.00 80.84  ? 241 PHE A CD2 1 
ATOM   1756 C CE1 . PHE A 1 215 ? 160.150 143.137 157.997 1.00 81.91  ? 241 PHE A CE1 1 
ATOM   1757 C CE2 . PHE A 1 215 ? 160.387 145.508 158.158 1.00 81.47  ? 241 PHE A CE2 1 
ATOM   1758 C CZ  . PHE A 1 215 ? 160.243 144.372 157.389 1.00 82.02  ? 241 PHE A CZ  1 
ATOM   1759 N N   . LYS A 1 216 ? 161.608 142.867 164.487 1.00 74.95  ? 242 LYS A N   1 
ATOM   1760 C CA  . LYS A 1 216 ? 161.652 142.974 165.938 1.00 75.29  ? 242 LYS A CA  1 
ATOM   1761 C C   . LYS A 1 216 ? 163.066 143.147 166.473 1.00 78.46  ? 242 LYS A C   1 
ATOM   1762 O O   . LYS A 1 216 ? 163.224 143.485 167.651 1.00 80.00  ? 242 LYS A O   1 
ATOM   1763 C CB  . LYS A 1 216 ? 161.008 141.742 166.575 1.00 75.89  ? 242 LYS A CB  1 
ATOM   1764 C CG  . LYS A 1 216 ? 159.574 141.497 166.140 1.00 77.39  ? 242 LYS A CG  1 
ATOM   1765 C CD  . LYS A 1 216 ? 159.008 140.245 166.789 1.00 79.57  ? 242 LYS A CD  1 
ATOM   1766 C CE  . LYS A 1 216 ? 157.604 139.951 166.292 1.00 77.79  ? 242 LYS A CE  1 
ATOM   1767 N NZ  . LYS A 1 216 ? 156.674 141.082 166.561 1.00 81.36  ? 242 LYS A NZ  1 
ATOM   1768 N N   . LEU A 1 217 ? 164.092 142.923 165.648 1.00 83.28  ? 243 LEU A N   1 
ATOM   1769 C CA  . LEU A 1 217 ? 165.461 143.088 166.123 1.00 84.56  ? 243 LEU A CA  1 
ATOM   1770 C C   . LEU A 1 217 ? 165.791 144.549 166.392 1.00 81.46  ? 243 LEU A C   1 
ATOM   1771 O O   . LEU A 1 217 ? 166.623 144.845 167.257 1.00 83.04  ? 243 LEU A O   1 
ATOM   1772 C CB  . LEU A 1 217 ? 166.446 142.500 165.114 1.00 85.35  ? 243 LEU A CB  1 
ATOM   1773 C CG  . LEU A 1 217 ? 166.388 140.985 164.907 1.00 86.32  ? 243 LEU A CG  1 
ATOM   1774 C CD1 . LEU A 1 217 ? 167.443 140.539 163.909 1.00 83.81  ? 243 LEU A CD1 1 
ATOM   1775 C CD2 . LEU A 1 217 ? 166.555 140.256 166.230 1.00 83.37  ? 243 LEU A CD2 1 
ATOM   1776 N N   . LEU A 1 218 ? 165.157 145.472 165.671 1.00 79.37  ? 244 LEU A N   1 
ATOM   1777 C CA  . LEU A 1 218 ? 165.431 146.891 165.825 1.00 83.19  ? 244 LEU A CA  1 
ATOM   1778 C C   . LEU A 1 218 ? 164.253 147.696 166.354 1.00 83.78  ? 244 LEU A C   1 
ATOM   1779 O O   . LEU A 1 218 ? 164.457 148.835 166.789 1.00 86.79  ? 244 LEU A O   1 
ATOM   1780 C CB  . LEU A 1 218 ? 165.882 147.501 164.487 1.00 84.34  ? 244 LEU A CB  1 
ATOM   1781 C CG  . LEU A 1 218 ? 167.250 147.100 163.924 1.00 86.91  ? 244 LEU A CG  1 
ATOM   1782 C CD1 . LEU A 1 218 ? 168.311 147.110 165.017 1.00 84.99  ? 244 LEU A CD1 1 
ATOM   1783 C CD2 . LEU A 1 218 ? 167.206 145.751 163.213 1.00 85.10  ? 244 LEU A CD2 1 
ATOM   1784 N N   . LEU A 1 219 ? 163.039 147.151 166.335 1.00 80.25  ? 245 LEU A N   1 
ATOM   1785 C CA  . LEU A 1 219 ? 161.852 147.888 166.740 1.00 80.68  ? 245 LEU A CA  1 
ATOM   1786 C C   . LEU A 1 219 ? 161.022 147.059 167.711 1.00 82.96  ? 245 LEU A C   1 
ATOM   1787 O O   . LEU A 1 219 ? 161.107 145.829 167.746 1.00 83.98  ? 245 LEU A O   1 
ATOM   1788 C CB  . LEU A 1 219 ? 160.994 148.279 165.529 1.00 80.61  ? 245 LEU A CB  1 
ATOM   1789 C CG  . LEU A 1 219 ? 161.645 149.187 164.485 1.00 82.97  ? 245 LEU A CG  1 
ATOM   1790 C CD1 . LEU A 1 219 ? 160.682 149.457 163.340 1.00 82.89  ? 245 LEU A CD1 1 
ATOM   1791 C CD2 . LEU A 1 219 ? 162.107 150.489 165.119 1.00 82.72  ? 245 LEU A CD2 1 
ATOM   1792 N N   . SER A 1 220 ? 160.216 147.759 168.506 1.00 86.98  ? 246 SER A N   1 
ATOM   1793 C CA  . SER A 1 220 ? 159.268 147.107 169.393 1.00 85.40  ? 246 SER A CA  1 
ATOM   1794 C C   . SER A 1 220 ? 158.073 146.584 168.596 1.00 86.70  ? 246 SER A C   1 
ATOM   1795 O O   . SER A 1 220 ? 157.911 146.865 167.406 1.00 90.49  ? 246 SER A O   1 
ATOM   1796 C CB  . SER A 1 220 ? 158.805 148.071 170.484 1.00 85.53  ? 246 SER A CB  1 
ATOM   1797 O OG  . SER A 1 220 ? 158.205 149.225 169.923 1.00 87.08  ? 246 SER A OG  1 
ATOM   1798 N N   . GLU A 1 221 ? 157.224 145.809 169.275 1.00 83.18  ? 247 GLU A N   1 
ATOM   1799 C CA  . GLU A 1 221 ? 156.090 145.188 168.595 1.00 84.05  ? 247 GLU A CA  1 
ATOM   1800 C C   . GLU A 1 221 ? 155.059 146.223 168.159 1.00 88.08  ? 247 GLU A C   1 
ATOM   1801 O O   . GLU A 1 221 ? 154.525 146.141 167.046 1.00 91.75  ? 247 GLU A O   1 
ATOM   1802 C CB  . GLU A 1 221 ? 155.450 144.139 169.503 1.00 86.24  ? 247 GLU A CB  1 
ATOM   1803 C CG  . GLU A 1 221 ? 154.244 143.443 168.895 1.00 88.73  ? 247 GLU A CG  1 
ATOM   1804 C CD  . GLU A 1 221 ? 153.635 142.415 169.827 1.00 90.77  ? 247 GLU A CD  1 
ATOM   1805 O OE1 . GLU A 1 221 ? 154.257 142.107 170.865 1.00 89.87  ? 247 GLU A OE1 1 
ATOM   1806 O OE2 . GLU A 1 221 ? 152.531 141.917 169.524 1.00 88.58  ? 247 GLU A OE2 1 
ATOM   1807 N N   . GLU A 1 222 ? 154.765 147.205 169.015 1.00 80.14  ? 248 GLU A N   1 
ATOM   1808 C CA  . GLU A 1 222 ? 153.797 148.233 168.644 1.00 79.54  ? 248 GLU A CA  1 
ATOM   1809 C C   . GLU A 1 222 ? 154.322 149.104 167.510 1.00 78.47  ? 248 GLU A C   1 
ATOM   1810 O O   . GLU A 1 222 ? 153.579 149.439 166.577 1.00 81.61  ? 248 GLU A O   1 
ATOM   1811 C CB  . GLU A 1 222 ? 153.439 149.084 169.864 1.00 80.69  ? 248 GLU A CB  1 
ATOM   1812 C CG  . GLU A 1 222 ? 154.636 149.614 170.637 1.00 82.31  ? 248 GLU A CG  1 
ATOM   1813 C CD  . GLU A 1 222 ? 154.232 150.473 171.819 1.00 85.98  ? 248 GLU A CD  1 
ATOM   1814 O OE1 . GLU A 1 222 ? 153.019 150.709 171.999 1.00 84.63  ? 248 GLU A OE1 1 
ATOM   1815 O OE2 . GLU A 1 222 ? 155.129 150.912 172.570 1.00 87.74  ? 248 GLU A OE2 1 
ATOM   1816 N N   . LEU A 1 223 ? 155.604 149.468 167.560 1.00 72.00  ? 249 LEU A N   1 
ATOM   1817 C CA  . LEU A 1 223 ? 156.178 150.247 166.472 1.00 74.85  ? 249 LEU A CA  1 
ATOM   1818 C C   . LEU A 1 223 ? 156.279 149.422 165.198 1.00 78.62  ? 249 LEU A C   1 
ATOM   1819 O O   . LEU A 1 223 ? 156.187 149.973 164.097 1.00 82.99  ? 249 LEU A O   1 
ATOM   1820 C CB  . LEU A 1 223 ? 157.550 150.784 166.877 1.00 78.04  ? 249 LEU A CB  1 
ATOM   1821 C CG  . LEU A 1 223 ? 157.795 152.263 166.579 1.00 80.30  ? 249 LEU A CG  1 
ATOM   1822 C CD1 . LEU A 1 223 ? 156.782 153.126 167.312 1.00 80.22  ? 249 LEU A CD1 1 
ATOM   1823 C CD2 . LEU A 1 223 ? 159.215 152.659 166.952 1.00 78.94  ? 249 LEU A CD2 1 
ATOM   1824 N N   . THR A 1 224 ? 156.456 148.105 165.324 1.00 74.48  ? 250 THR A N   1 
ATOM   1825 C CA  . THR A 1 224 ? 156.421 147.240 164.149 1.00 70.74  ? 250 THR A CA  1 
ATOM   1826 C C   . THR A 1 224 ? 155.026 147.199 163.540 1.00 71.10  ? 250 THR A C   1 
ATOM   1827 O O   . THR A 1 224 ? 154.877 147.204 162.313 1.00 78.90  ? 250 THR A O   1 
ATOM   1828 C CB  . THR A 1 224 ? 156.885 145.831 164.517 1.00 72.04  ? 250 THR A CB  1 
ATOM   1829 O OG1 . THR A 1 224 ? 158.196 145.892 165.090 1.00 74.76  ? 250 THR A OG1 1 
ATOM   1830 C CG2 . THR A 1 224 ? 156.922 144.942 163.286 1.00 72.88  ? 250 THR A CG2 1 
ATOM   1831 N N   . SER A 1 225 ? 153.992 147.170 164.380 1.00 63.08  ? 251 SER A N   1 
ATOM   1832 C CA  . SER A 1 225 ? 152.625 147.104 163.880 1.00 63.39  ? 251 SER A CA  1 
ATOM   1833 C C   . SER A 1 225 ? 152.111 148.448 163.389 1.00 62.65  ? 251 SER A C   1 
ATOM   1834 O O   . SER A 1 225 ? 151.102 148.485 162.677 1.00 66.31  ? 251 SER A O   1 
ATOM   1835 C CB  . SER A 1 225 ? 151.693 146.568 164.968 1.00 64.56  ? 251 SER A CB  1 
ATOM   1836 O OG  . SER A 1 225 ? 150.345 146.573 164.532 1.00 65.70  ? 251 SER A OG  1 
ATOM   1837 N N   . LEU A 1 226 ? 152.772 149.547 163.748 1.00 65.01  ? 252 LEU A N   1 
ATOM   1838 C CA  . LEU A 1 226 ? 152.357 150.862 163.272 1.00 65.29  ? 252 LEU A CA  1 
ATOM   1839 C C   . LEU A 1 226 ? 153.174 151.349 162.079 1.00 67.64  ? 252 LEU A C   1 
ATOM   1840 O O   . LEU A 1 226 ? 152.601 151.776 161.072 1.00 71.83  ? 252 LEU A O   1 
ATOM   1841 C CB  . LEU A 1 226 ? 152.441 151.884 164.412 1.00 67.83  ? 252 LEU A CB  1 
ATOM   1842 C CG  . LEU A 1 226 ? 151.888 153.276 164.104 1.00 66.75  ? 252 LEU A CG  1 
ATOM   1843 C CD1 . LEU A 1 226 ? 150.406 153.204 163.781 1.00 64.15  ? 252 LEU A CD1 1 
ATOM   1844 C CD2 . LEU A 1 226 ? 152.139 154.224 165.263 1.00 67.97  ? 252 LEU A CD2 1 
ATOM   1845 N N   . LEU A 1 227 ? 154.505 151.297 162.169 1.00 68.23  ? 253 LEU A N   1 
ATOM   1846 C CA  . LEU A 1 227 ? 155.345 151.809 161.090 1.00 65.22  ? 253 LEU A CA  1 
ATOM   1847 C C   . LEU A 1 227 ? 155.328 150.890 159.875 1.00 64.59  ? 253 LEU A C   1 
ATOM   1848 O O   . LEU A 1 227 ? 155.205 151.360 158.738 1.00 71.53  ? 253 LEU A O   1 
ATOM   1849 C CB  . LEU A 1 227 ? 156.779 151.999 161.583 1.00 64.94  ? 253 LEU A CB  1 
ATOM   1850 C CG  . LEU A 1 227 ? 157.054 153.105 162.600 1.00 68.05  ? 253 LEU A CG  1 
ATOM   1851 C CD1 . LEU A 1 227 ? 158.507 153.058 163.041 1.00 67.05  ? 253 LEU A CD1 1 
ATOM   1852 C CD2 . LEU A 1 227 ? 156.720 154.463 162.014 1.00 67.41  ? 253 LEU A CD2 1 
ATOM   1853 N N   . VAL A 1 228 ? 155.450 149.585 160.089 1.00 54.23  ? 254 VAL A N   1 
ATOM   1854 C CA  . VAL A 1 228 ? 155.668 148.652 158.988 1.00 56.33  ? 254 VAL A CA  1 
ATOM   1855 C C   . VAL A 1 228 ? 154.355 148.167 158.392 1.00 61.66  ? 254 VAL A C   1 
ATOM   1856 O O   . VAL A 1 228 ? 154.156 148.225 157.176 1.00 65.67  ? 254 VAL A O   1 
ATOM   1857 C CB  . VAL A 1 228 ? 156.534 147.469 159.468 1.00 59.66  ? 254 VAL A CB  1 
ATOM   1858 C CG1 . VAL A 1 228 ? 156.743 146.473 158.342 1.00 61.68  ? 254 VAL A CG1 1 
ATOM   1859 C CG2 . VAL A 1 228 ? 157.867 147.970 160.001 1.00 64.58  ? 254 VAL A CG2 1 
ATOM   1860 N N   . VAL A 1 229 ? 153.441 147.677 159.230 1.00 55.65  ? 255 VAL A N   1 
ATOM   1861 C CA  . VAL A 1 229 ? 152.236 147.035 158.713 1.00 55.12  ? 255 VAL A CA  1 
ATOM   1862 C C   . VAL A 1 229 ? 151.275 148.061 158.123 1.00 61.35  ? 255 VAL A C   1 
ATOM   1863 O O   . VAL A 1 229 ? 150.704 147.845 157.048 1.00 67.21  ? 255 VAL A O   1 
ATOM   1864 C CB  . VAL A 1 229 ? 151.565 146.199 159.817 1.00 53.74  ? 255 VAL A CB  1 
ATOM   1865 C CG1 . VAL A 1 229 ? 150.396 145.413 159.251 1.00 56.09  ? 255 VAL A CG1 1 
ATOM   1866 C CG2 . VAL A 1 229 ? 152.575 145.265 160.462 1.00 57.84  ? 255 VAL A CG2 1 
ATOM   1867 N N   . HIS A 1 230 ? 151.079 149.191 158.805 1.00 57.71  ? 256 HIS A N   1 
ATOM   1868 C CA  . HIS A 1 230 ? 150.011 150.115 158.431 1.00 54.77  ? 256 HIS A CA  1 
ATOM   1869 C C   . HIS A 1 230 ? 150.483 151.217 157.484 1.00 57.27  ? 256 HIS A C   1 
ATOM   1870 O O   . HIS A 1 230 ? 149.965 151.348 156.370 1.00 64.13  ? 256 HIS A O   1 
ATOM   1871 C CB  . HIS A 1 230 ? 149.391 150.726 159.691 1.00 56.41  ? 256 HIS A CB  1 
ATOM   1872 C CG  . HIS A 1 230 ? 148.582 149.756 160.492 1.00 60.30  ? 256 HIS A CG  1 
ATOM   1873 N ND1 . HIS A 1 230 ? 149.143 148.681 161.146 1.00 64.53  ? 256 HIS A ND1 1 
ATOM   1874 C CD2 . HIS A 1 230 ? 147.253 149.693 160.738 1.00 57.59  ? 256 HIS A CD2 1 
ATOM   1875 C CE1 . HIS A 1 230 ? 148.194 148.001 161.764 1.00 61.64  ? 256 HIS A CE1 1 
ATOM   1876 N NE2 . HIS A 1 230 ? 147.038 148.595 161.533 1.00 61.13  ? 256 HIS A NE2 1 
ATOM   1877 N N   . TRP A 1 231 ? 151.461 152.019 157.912 1.00 59.26  ? 257 TRP A N   1 
ATOM   1878 C CA  . TRP A 1 231 ? 151.951 153.091 157.052 1.00 60.78  ? 257 TRP A CA  1 
ATOM   1879 C C   . TRP A 1 231 ? 152.735 152.541 155.869 1.00 64.16  ? 257 TRP A C   1 
ATOM   1880 O O   . TRP A 1 231 ? 152.665 153.095 154.761 1.00 71.90  ? 257 TRP A O   1 
ATOM   1881 C CB  . TRP A 1 231 ? 152.812 154.059 157.859 1.00 54.36  ? 257 TRP A CB  1 
ATOM   1882 C CG  . TRP A 1 231 ? 152.043 154.820 158.890 1.00 57.76  ? 257 TRP A CG  1 
ATOM   1883 C CD1 . TRP A 1 231 ? 150.688 154.903 159.001 1.00 63.21  ? 257 TRP A CD1 1 
ATOM   1884 C CD2 . TRP A 1 231 ? 152.582 155.602 159.961 1.00 63.55  ? 257 TRP A CD2 1 
ATOM   1885 N NE1 . TRP A 1 231 ? 150.347 155.691 160.073 1.00 64.81  ? 257 TRP A NE1 1 
ATOM   1886 C CE2 . TRP A 1 231 ? 151.493 156.132 160.679 1.00 66.84  ? 257 TRP A CE2 1 
ATOM   1887 C CE3 . TRP A 1 231 ? 153.879 155.907 160.382 1.00 65.74  ? 257 TRP A CE3 1 
ATOM   1888 C CZ2 . TRP A 1 231 ? 151.662 156.949 161.794 1.00 67.20  ? 257 TRP A CZ2 1 
ATOM   1889 C CZ3 . TRP A 1 231 ? 154.044 156.717 161.489 1.00 64.84  ? 257 TRP A CZ3 1 
ATOM   1890 C CH2 . TRP A 1 231 ? 152.943 157.229 162.182 1.00 65.89  ? 257 TRP A CH2 1 
ATOM   1891 N N   . GLY A 1 232 ? 153.469 151.449 156.083 1.00 47.49  ? 258 GLY A N   1 
ATOM   1892 C CA  . GLY A 1 232 ? 154.212 150.845 154.994 1.00 46.61  ? 258 GLY A CA  1 
ATOM   1893 C C   . GLY A 1 232 ? 153.311 150.354 153.880 1.00 54.01  ? 258 GLY A C   1 
ATOM   1894 O O   . GLY A 1 232 ? 153.652 150.474 152.705 1.00 60.64  ? 258 GLY A O   1 
ATOM   1895 N N   . GLY A 1 233 ? 152.142 149.814 154.229 1.00 45.31  ? 259 GLY A N   1 
ATOM   1896 C CA  . GLY A 1 233 ? 151.224 149.345 153.204 1.00 42.34  ? 259 GLY A CA  1 
ATOM   1897 C C   . GLY A 1 233 ? 150.694 150.464 152.327 1.00 45.15  ? 259 GLY A C   1 
ATOM   1898 O O   . GLY A 1 233 ? 150.644 150.333 151.102 1.00 54.65  ? 259 GLY A O   1 
ATOM   1899 N N   . LEU A 1 234 ? 150.308 151.585 152.938 1.00 47.25  ? 260 LEU A N   1 
ATOM   1900 C CA  . LEU A 1 234 ? 149.818 152.728 152.172 1.00 51.96  ? 260 LEU A CA  1 
ATOM   1901 C C   . LEU A 1 234 ? 150.918 153.318 151.294 1.00 55.49  ? 260 LEU A C   1 
ATOM   1902 O O   . LEU A 1 234 ? 150.707 153.588 150.097 1.00 59.18  ? 260 LEU A O   1 
ATOM   1903 C CB  . LEU A 1 234 ? 149.263 153.779 153.134 1.00 45.34  ? 260 LEU A CB  1 
ATOM   1904 C CG  . LEU A 1 234 ? 149.214 155.243 152.704 1.00 51.49  ? 260 LEU A CG  1 
ATOM   1905 C CD1 . LEU A 1 234 ? 148.249 155.452 151.549 1.00 54.74  ? 260 LEU A CD1 1 
ATOM   1906 C CD2 . LEU A 1 234 ? 148.834 156.110 153.889 1.00 49.44  ? 260 LEU A CD2 1 
ATOM   1907 N N   . LEU A 1 235 ? 152.104 153.524 151.876 1.00 44.06  ? 261 LEU A N   1 
ATOM   1908 C CA  . LEU A 1 235 ? 153.214 154.056 151.098 1.00 40.34  ? 261 LEU A CA  1 
ATOM   1909 C C   . LEU A 1 235 ? 153.576 153.120 149.956 1.00 44.24  ? 261 LEU A C   1 
ATOM   1910 O O   . LEU A 1 235 ? 153.867 153.573 148.845 1.00 55.16  ? 261 LEU A O   1 
ATOM   1911 C CB  . LEU A 1 235 ? 154.426 154.301 151.997 1.00 44.76  ? 261 LEU A CB  1 
ATOM   1912 C CG  . LEU A 1 235 ? 154.395 155.571 152.844 1.00 48.05  ? 261 LEU A CG  1 
ATOM   1913 C CD1 . LEU A 1 235 ? 155.667 155.695 153.666 1.00 49.09  ? 261 LEU A CD1 1 
ATOM   1914 C CD2 . LEU A 1 235 ? 154.203 156.795 151.964 1.00 48.82  ? 261 LEU A CD2 1 
ATOM   1915 N N   . LEU A 1 236 ? 153.547 151.810 150.205 1.00 45.65  ? 262 LEU A N   1 
ATOM   1916 C CA  . LEU A 1 236 ? 153.874 150.851 149.163 1.00 48.18  ? 262 LEU A CA  1 
ATOM   1917 C C   . LEU A 1 236 ? 152.812 150.825 148.080 1.00 51.64  ? 262 LEU A C   1 
ATOM   1918 O O   . LEU A 1 236 ? 153.147 150.675 146.907 1.00 54.37  ? 262 LEU A O   1 
ATOM   1919 C CB  . LEU A 1 236 ? 154.061 149.459 149.768 1.00 51.12  ? 262 LEU A CB  1 
ATOM   1920 C CG  . LEU A 1 236 ? 154.892 148.452 148.970 1.00 53.85  ? 262 LEU A CG  1 
ATOM   1921 C CD1 . LEU A 1 236 ? 155.537 147.454 149.914 1.00 55.95  ? 262 LEU A CD1 1 
ATOM   1922 C CD2 . LEU A 1 236 ? 154.049 147.727 147.933 1.00 50.52  ? 262 LEU A CD2 1 
ATOM   1923 N N   . ASP A 1 237 ? 151.539 150.993 148.438 1.00 53.04  ? 263 ASP A N   1 
ATOM   1924 C CA  . ASP A 1 237 ? 150.499 151.065 147.416 1.00 50.21  ? 263 ASP A CA  1 
ATOM   1925 C C   . ASP A 1 237 ? 150.737 152.243 146.481 1.00 57.25  ? 263 ASP A C   1 
ATOM   1926 O O   . ASP A 1 237 ? 150.793 152.077 145.253 1.00 66.57  ? 263 ASP A O   1 
ATOM   1927 C CB  . ASP A 1 237 ? 149.122 151.162 148.070 1.00 50.12  ? 263 ASP A CB  1 
ATOM   1928 C CG  . ASP A 1 237 ? 148.708 149.873 148.750 1.00 62.47  ? 263 ASP A CG  1 
ATOM   1929 O OD1 . ASP A 1 237 ? 149.496 148.906 148.723 1.00 59.51  ? 263 ASP A OD1 1 
ATOM   1930 O OD2 . ASP A 1 237 ? 147.594 149.826 149.312 1.00 63.72  ? 263 ASP A OD2 1 
ATOM   1931 N N   . LEU A 1 238 ? 150.916 153.441 147.045 1.00 46.83  ? 264 LEU A N   1 
ATOM   1932 C CA  . LEU A 1 238 ? 151.095 154.616 146.192 1.00 46.09  ? 264 LEU A CA  1 
ATOM   1933 C C   . LEU A 1 238 ? 152.400 154.541 145.396 1.00 46.29  ? 264 LEU A C   1 
ATOM   1934 O O   . LEU A 1 238 ? 152.426 154.830 144.188 1.00 42.45  ? 264 LEU A O   1 
ATOM   1935 C CB  . LEU A 1 238 ? 151.037 155.885 147.040 1.00 45.56  ? 264 LEU A CB  1 
ATOM   1936 C CG  . LEU A 1 238 ? 149.785 155.994 147.919 1.00 45.58  ? 264 LEU A CG  1 
ATOM   1937 C CD1 . LEU A 1 238 ? 149.759 157.302 148.692 1.00 42.56  ? 264 LEU A CD1 1 
ATOM   1938 C CD2 . LEU A 1 238 ? 148.522 155.840 147.088 1.00 46.70  ? 264 LEU A CD2 1 
ATOM   1939 N N   . SER A 1 239 ? 153.490 154.122 146.045 1.00 48.62  ? 265 SER A N   1 
ATOM   1940 C CA  . SER A 1 239 ? 154.773 154.046 145.362 1.00 47.61  ? 265 SER A CA  1 
ATOM   1941 C C   . SER A 1 239 ? 154.795 152.942 144.314 1.00 54.05  ? 265 SER A C   1 
ATOM   1942 O O   . SER A 1 239 ? 155.448 153.094 143.284 1.00 60.22  ? 265 SER A O   1 
ATOM   1943 C CB  . SER A 1 239 ? 155.896 153.839 146.378 1.00 55.13  ? 265 SER A CB  1 
ATOM   1944 O OG  . SER A 1 239 ? 155.687 152.664 147.140 1.00 57.71  ? 265 SER A OG  1 
ATOM   1945 N N   . ALA A 1 240 ? 154.105 151.825 144.547 1.00 51.91  ? 266 ALA A N   1 
ATOM   1946 C CA  . ALA A 1 240 ? 154.015 150.797 143.523 1.00 53.30  ? 266 ALA A CA  1 
ATOM   1947 C C   . ALA A 1 240 ? 153.166 151.266 142.358 1.00 54.18  ? 266 ALA A C   1 
ATOM   1948 O O   . ALA A 1 240 ? 153.408 150.867 141.213 1.00 56.01  ? 266 ALA A O   1 
ATOM   1949 C CB  . ALA A 1 240 ? 153.442 149.512 144.118 1.00 54.14  ? 266 ALA A CB  1 
ATOM   1950 N N   . GLY A 1 241 ? 152.166 152.105 142.629 1.00 48.07  ? 267 GLY A N   1 
ATOM   1951 C CA  . GLY A 1 241 ? 151.431 152.717 141.538 1.00 50.32  ? 267 GLY A CA  1 
ATOM   1952 C C   . GLY A 1 241 ? 152.318 153.577 140.661 1.00 50.74  ? 267 GLY A C   1 
ATOM   1953 O O   . GLY A 1 241 ? 152.253 153.508 139.431 1.00 45.11  ? 267 GLY A O   1 
ATOM   1954 N N   . PHE A 1 242 ? 153.174 154.390 141.281 1.00 55.07  ? 268 PHE A N   1 
ATOM   1955 C CA  . PHE A 1 242 ? 153.902 155.401 140.515 1.00 48.92  ? 268 PHE A CA  1 
ATOM   1956 C C   . PHE A 1 242 ? 155.273 154.964 140.003 1.00 42.50  ? 268 PHE A C   1 
ATOM   1957 O O   . PHE A 1 242 ? 155.673 155.401 138.920 1.00 46.13  ? 268 PHE A O   1 
ATOM   1958 C CB  . PHE A 1 242 ? 154.066 156.678 141.344 1.00 45.68  ? 268 PHE A CB  1 
ATOM   1959 C CG  . PHE A 1 242 ? 152.934 157.648 141.181 1.00 44.04  ? 268 PHE A CG  1 
ATOM   1960 C CD1 . PHE A 1 242 ? 152.958 158.591 140.170 1.00 47.57  ? 268 PHE A CD1 1 
ATOM   1961 C CD2 . PHE A 1 242 ? 151.842 157.609 142.028 1.00 49.02  ? 268 PHE A CD2 1 
ATOM   1962 C CE1 . PHE A 1 242 ? 151.916 159.483 140.010 1.00 52.55  ? 268 PHE A CE1 1 
ATOM   1963 C CE2 . PHE A 1 242 ? 150.797 158.499 141.874 1.00 50.20  ? 268 PHE A CE2 1 
ATOM   1964 C CZ  . PHE A 1 242 ? 150.834 159.437 140.864 1.00 50.42  ? 268 PHE A CZ  1 
ATOM   1965 N N   . LEU A 1 243 ? 156.007 154.119 140.730 1.00 42.57  ? 269 LEU A N   1 
ATOM   1966 C CA  . LEU A 1 243 ? 157.399 153.842 140.387 1.00 47.71  ? 269 LEU A CA  1 
ATOM   1967 C C   . LEU A 1 243 ? 157.542 152.895 139.203 1.00 58.18  ? 269 LEU A C   1 
ATOM   1968 O O   . LEU A 1 243 ? 158.495 153.029 138.427 1.00 62.08  ? 269 LEU A O   1 
ATOM   1969 C CB  . LEU A 1 243 ? 158.137 153.256 141.593 1.00 51.27  ? 269 LEU A CB  1 
ATOM   1970 C CG  . LEU A 1 243 ? 158.332 154.141 142.827 1.00 52.31  ? 269 LEU A CG  1 
ATOM   1971 C CD1 . LEU A 1 243 ? 159.118 153.395 143.893 1.00 49.72  ? 269 LEU A CD1 1 
ATOM   1972 C CD2 . LEU A 1 243 ? 159.012 155.452 142.469 1.00 53.66  ? 269 LEU A CD2 1 
ATOM   1973 N N   . LEU A 1 244 ? 156.627 151.935 139.048 1.00 52.56  ? 270 LEU A N   1 
ATOM   1974 C CA  . LEU A 1 244 ? 156.765 150.949 137.982 1.00 47.02  ? 270 LEU A CA  1 
ATOM   1975 C C   . LEU A 1 244 ? 156.683 151.574 136.598 1.00 52.55  ? 270 LEU A C   1 
ATOM   1976 O O   . LEU A 1 244 ? 157.193 150.989 135.636 1.00 54.94  ? 270 LEU A O   1 
ATOM   1977 C CB  . LEU A 1 244 ? 155.696 149.866 138.120 1.00 41.50  ? 270 LEU A CB  1 
ATOM   1978 C CG  . LEU A 1 244 ? 155.825 148.910 139.303 1.00 48.31  ? 270 LEU A CG  1 
ATOM   1979 C CD1 . LEU A 1 244 ? 154.694 147.897 139.292 1.00 50.25  ? 270 LEU A CD1 1 
ATOM   1980 C CD2 . LEU A 1 244 ? 157.172 148.209 139.278 1.00 54.15  ? 270 LEU A CD2 1 
ATOM   1981 N N   . PHE A 1 245 ? 156.058 152.745 136.475 1.00 50.90  ? 271 PHE A N   1 
ATOM   1982 C CA  . PHE A 1 245 ? 155.913 153.374 135.168 1.00 46.93  ? 271 PHE A CA  1 
ATOM   1983 C C   . PHE A 1 245 ? 157.236 153.941 134.670 1.00 50.00  ? 271 PHE A C   1 
ATOM   1984 O O   . PHE A 1 245 ? 157.590 153.763 133.499 1.00 58.62  ? 271 PHE A O   1 
ATOM   1985 C CB  . PHE A 1 245 ? 154.847 154.466 135.237 1.00 46.63  ? 271 PHE A CB  1 
ATOM   1986 C CG  . PHE A 1 245 ? 154.575 155.130 133.923 1.00 53.60  ? 271 PHE A CG  1 
ATOM   1987 C CD1 . PHE A 1 245 ? 153.898 154.458 132.922 1.00 56.76  ? 271 PHE A CD1 1 
ATOM   1988 C CD2 . PHE A 1 245 ? 154.985 156.430 133.693 1.00 58.55  ? 271 PHE A CD2 1 
ATOM   1989 C CE1 . PHE A 1 245 ? 153.643 155.070 131.711 1.00 57.33  ? 271 PHE A CE1 1 
ATOM   1990 C CE2 . PHE A 1 245 ? 154.731 157.046 132.485 1.00 56.66  ? 271 PHE A CE2 1 
ATOM   1991 C CZ  . PHE A 1 245 ? 154.060 156.365 131.494 1.00 53.56  ? 271 PHE A CZ  1 
ATOM   1992 N N   . PHE A 1 246 ? 157.979 154.620 135.536 1.00 46.56  ? 272 PHE A N   1 
ATOM   1993 C CA  . PHE A 1 246 ? 159.206 155.284 135.124 1.00 49.87  ? 272 PHE A CA  1 
ATOM   1994 C C   . PHE A 1 246 ? 160.369 154.300 135.052 1.00 55.23  ? 272 PHE A C   1 
ATOM   1995 O O   . PHE A 1 246 ? 160.433 153.321 135.801 1.00 60.23  ? 272 PHE A O   1 
ATOM   1996 C CB  . PHE A 1 246 ? 159.538 156.427 136.080 1.00 48.50  ? 272 PHE A CB  1 
ATOM   1997 C CG  . PHE A 1 246 ? 158.479 157.488 136.139 1.00 49.25  ? 272 PHE A CG  1 
ATOM   1998 C CD1 . PHE A 1 246 ? 158.453 158.508 135.208 1.00 49.63  ? 272 PHE A CD1 1 
ATOM   1999 C CD2 . PHE A 1 246 ? 157.507 157.462 137.121 1.00 52.17  ? 272 PHE A CD2 1 
ATOM   2000 C CE1 . PHE A 1 246 ? 157.481 159.482 135.256 1.00 50.06  ? 272 PHE A CE1 1 
ATOM   2001 C CE2 . PHE A 1 246 ? 156.532 158.436 137.173 1.00 50.69  ? 272 PHE A CE2 1 
ATOM   2002 C CZ  . PHE A 1 246 ? 156.521 159.447 136.239 1.00 49.74  ? 272 PHE A CZ  1 
ATOM   2003 N N   . ASP A 1 247 ? 161.298 154.576 134.133 1.00 57.05  ? 273 ASP A N   1 
ATOM   2004 C CA  . ASP A 1 247 ? 162.401 153.653 133.886 1.00 56.58  ? 273 ASP A CA  1 
ATOM   2005 C C   . ASP A 1 247 ? 163.428 153.672 135.010 1.00 59.16  ? 273 ASP A C   1 
ATOM   2006 O O   . ASP A 1 247 ? 164.087 152.656 135.258 1.00 65.15  ? 273 ASP A O   1 
ATOM   2007 C CB  . ASP A 1 247 ? 163.077 153.986 132.557 1.00 59.87  ? 273 ASP A CB  1 
ATOM   2008 C CG  . ASP A 1 247 ? 162.133 153.869 131.376 1.00 67.64  ? 273 ASP A CG  1 
ATOM   2009 O OD1 . ASP A 1 247 ? 161.236 153.001 131.415 1.00 69.36  ? 273 ASP A OD1 1 
ATOM   2010 O OD2 . ASP A 1 247 ? 162.287 154.645 130.409 1.00 68.57  ? 273 ASP A OD2 1 
ATOM   2011 N N   . VAL A 1 248 ? 163.584 154.807 135.692 1.00 59.09  ? 274 VAL A N   1 
ATOM   2012 C CA  . VAL A 1 248 ? 164.611 154.916 136.724 1.00 59.75  ? 274 VAL A CA  1 
ATOM   2013 C C   . VAL A 1 248 ? 164.268 154.044 137.925 1.00 58.38  ? 274 VAL A C   1 
ATOM   2014 O O   . VAL A 1 248 ? 165.135 153.357 138.478 1.00 59.64  ? 274 VAL A O   1 
ATOM   2015 C CB  . VAL A 1 248 ? 164.800 156.388 137.129 1.00 60.77  ? 274 VAL A CB  1 
ATOM   2016 C CG1 . VAL A 1 248 ? 165.866 156.509 138.206 1.00 61.49  ? 274 VAL A CG1 1 
ATOM   2017 C CG2 . VAL A 1 248 ? 165.164 157.229 135.916 1.00 58.33  ? 274 VAL A CG2 1 
ATOM   2018 N N   . SER A 1 249 ? 163.005 154.050 138.345 1.00 55.32  ? 275 SER A N   1 
ATOM   2019 C CA  . SER A 1 249 ? 162.588 153.419 139.589 1.00 56.72  ? 275 SER A CA  1 
ATOM   2020 C C   . SER A 1 249 ? 161.837 152.109 139.375 1.00 55.49  ? 275 SER A C   1 
ATOM   2021 O O   . SER A 1 249 ? 161.083 151.686 140.258 1.00 62.77  ? 275 SER A O   1 
ATOM   2022 C CB  . SER A 1 249 ? 161.728 154.388 140.402 1.00 60.44  ? 275 SER A CB  1 
ATOM   2023 O OG  . SER A 1 249 ? 162.428 155.590 140.670 1.00 65.23  ? 275 SER A OG  1 
ATOM   2024 N N   . ARG A 1 250 ? 162.019 151.458 138.226 1.00 48.63  ? 276 ARG A N   1 
ATOM   2025 C CA  . ARG A 1 250 ? 161.269 150.235 137.967 1.00 48.29  ? 276 ARG A CA  1 
ATOM   2026 C C   . ARG A 1 250 ? 161.827 149.047 138.743 1.00 55.31  ? 276 ARG A C   1 
ATOM   2027 O O   . ARG A 1 250 ? 161.061 148.195 139.204 1.00 60.05  ? 276 ARG A O   1 
ATOM   2028 C CB  . ARG A 1 250 ? 161.249 149.929 136.469 1.00 51.26  ? 276 ARG A CB  1 
ATOM   2029 C CG  . ARG A 1 250 ? 160.392 148.726 136.109 1.00 51.68  ? 276 ARG A CG  1 
ATOM   2030 C CD  . ARG A 1 250 ? 160.300 148.509 134.610 1.00 53.72  ? 276 ARG A CD  1 
ATOM   2031 N NE  . ARG A 1 250 ? 159.554 149.569 133.943 1.00 52.06  ? 276 ARG A NE  1 
ATOM   2032 C CZ  . ARG A 1 250 ? 160.105 150.520 133.203 1.00 54.01  ? 276 ARG A CZ  1 
ATOM   2033 N NH1 . ARG A 1 250 ? 161.411 150.566 132.999 1.00 57.67  ? 276 ARG A NH1 1 
ATOM   2034 N NH2 . ARG A 1 250 ? 159.326 151.445 132.652 1.00 52.01  ? 276 ARG A NH2 1 
ATOM   2035 N N   . SER A 1 251 ? 163.150 148.967 138.902 1.00 52.48  ? 277 SER A N   1 
ATOM   2036 C CA  . SER A 1 251 ? 163.744 147.818 139.582 1.00 53.74  ? 277 SER A CA  1 
ATOM   2037 C C   . SER A 1 251 ? 163.399 147.811 141.069 1.00 60.85  ? 277 SER A C   1 
ATOM   2038 O O   . SER A 1 251 ? 163.027 146.770 141.628 1.00 61.17  ? 277 SER A O   1 
ATOM   2039 C CB  . SER A 1 251 ? 165.258 147.817 139.378 1.00 50.94  ? 277 SER A CB  1 
ATOM   2040 O OG  . SER A 1 251 ? 165.837 149.016 139.861 1.00 57.53  ? 277 SER A OG  1 
ATOM   2041 N N   . ILE A 1 252 ? 163.518 148.967 141.725 1.00 58.84  ? 278 ILE A N   1 
ATOM   2042 C CA  . ILE A 1 252 ? 163.171 149.064 143.139 1.00 54.30  ? 278 ILE A CA  1 
ATOM   2043 C C   . ILE A 1 252 ? 161.690 148.774 143.343 1.00 56.38  ? 278 ILE A C   1 
ATOM   2044 O O   . ILE A 1 252 ? 161.300 148.082 144.294 1.00 62.78  ? 278 ILE A O   1 
ATOM   2045 C CB  . ILE A 1 252 ? 163.560 150.450 143.683 1.00 55.81  ? 278 ILE A CB  1 
ATOM   2046 C CG1 . ILE A 1 252 ? 165.064 150.676 143.534 1.00 59.28  ? 278 ILE A CG1 1 
ATOM   2047 C CG2 . ILE A 1 252 ? 163.140 150.594 145.134 1.00 61.27  ? 278 ILE A CG2 1 
ATOM   2048 C CD1 . ILE A 1 252 ? 165.908 149.678 144.294 1.00 59.77  ? 278 ILE A CD1 1 
ATOM   2049 N N   . GLY A 1 253 ? 160.845 149.298 142.455 1.00 54.64  ? 279 GLY A N   1 
ATOM   2050 C CA  . GLY A 1 253 ? 159.424 149.015 142.547 1.00 56.19  ? 279 GLY A CA  1 
ATOM   2051 C C   . GLY A 1 253 ? 159.116 147.542 142.375 1.00 57.57  ? 279 GLY A C   1 
ATOM   2052 O O   . GLY A 1 253 ? 158.282 146.988 143.093 1.00 64.75  ? 279 GLY A O   1 
ATOM   2053 N N   . LEU A 1 254 ? 159.793 146.884 141.430 1.00 50.96  ? 280 LEU A N   1 
ATOM   2054 C CA  . LEU A 1 254 ? 159.591 145.452 141.242 1.00 53.49  ? 280 LEU A CA  1 
ATOM   2055 C C   . LEU A 1 254 ? 160.005 144.672 142.481 1.00 56.91  ? 280 LEU A C   1 
ATOM   2056 O O   . LEU A 1 254 ? 159.297 143.753 142.908 1.00 60.99  ? 280 LEU A O   1 
ATOM   2057 C CB  . LEU A 1 254 ? 160.370 144.962 140.022 1.00 52.38  ? 280 LEU A CB  1 
ATOM   2058 C CG  . LEU A 1 254 ? 159.764 145.231 138.644 1.00 57.58  ? 280 LEU A CG  1 
ATOM   2059 C CD1 . LEU A 1 254 ? 160.678 144.699 137.554 1.00 56.05  ? 280 LEU A CD1 1 
ATOM   2060 C CD2 . LEU A 1 254 ? 158.381 144.611 138.535 1.00 56.72  ? 280 LEU A CD2 1 
ATOM   2061 N N   . PHE A 1 255 ? 161.142 145.032 143.078 1.00 55.82  ? 281 PHE A N   1 
ATOM   2062 C CA  . PHE A 1 255 ? 161.597 144.332 144.276 1.00 56.81  ? 281 PHE A CA  1 
ATOM   2063 C C   . PHE A 1 255 ? 160.606 144.499 145.422 1.00 60.99  ? 281 PHE A C   1 
ATOM   2064 O O   . PHE A 1 255 ? 160.227 143.520 146.081 1.00 64.19  ? 281 PHE A O   1 
ATOM   2065 C CB  . PHE A 1 255 ? 162.982 144.839 144.680 1.00 55.93  ? 281 PHE A CB  1 
ATOM   2066 C CG  . PHE A 1 255 ? 163.463 144.308 145.998 1.00 59.81  ? 281 PHE A CG  1 
ATOM   2067 C CD1 . PHE A 1 255 ? 163.989 143.032 146.095 1.00 61.18  ? 281 PHE A CD1 1 
ATOM   2068 C CD2 . PHE A 1 255 ? 163.400 145.089 147.139 1.00 60.50  ? 281 PHE A CD2 1 
ATOM   2069 C CE1 . PHE A 1 255 ? 164.436 142.541 147.306 1.00 64.01  ? 281 PHE A CE1 1 
ATOM   2070 C CE2 . PHE A 1 255 ? 163.844 144.604 148.353 1.00 62.89  ? 281 PHE A CE2 1 
ATOM   2071 C CZ  . PHE A 1 255 ? 164.363 143.329 148.436 1.00 65.11  ? 281 PHE A CZ  1 
ATOM   2072 N N   . PHE A 1 256 ? 160.162 145.736 145.665 1.00 56.37  ? 282 PHE A N   1 
ATOM   2073 C CA  . PHE A 1 256 ? 159.226 145.980 146.758 1.00 51.40  ? 282 PHE A CA  1 
ATOM   2074 C C   . PHE A 1 256 ? 157.891 145.290 146.512 1.00 54.97  ? 282 PHE A C   1 
ATOM   2075 O O   . PHE A 1 256 ? 157.307 144.711 147.436 1.00 61.32  ? 282 PHE A O   1 
ATOM   2076 C CB  . PHE A 1 256 ? 159.028 147.481 146.960 1.00 48.52  ? 282 PHE A CB  1 
ATOM   2077 C CG  . PHE A 1 256 ? 160.165 148.149 147.675 1.00 53.35  ? 282 PHE A CG  1 
ATOM   2078 C CD1 . PHE A 1 256 ? 161.023 147.416 148.476 1.00 55.95  ? 282 PHE A CD1 1 
ATOM   2079 C CD2 . PHE A 1 256 ? 160.375 149.511 147.550 1.00 55.86  ? 282 PHE A CD2 1 
ATOM   2080 C CE1 . PHE A 1 256 ? 162.070 148.028 149.137 1.00 58.16  ? 282 PHE A CE1 1 
ATOM   2081 C CE2 . PHE A 1 256 ? 161.420 150.129 148.209 1.00 57.25  ? 282 PHE A CE2 1 
ATOM   2082 C CZ  . PHE A 1 256 ? 162.268 149.386 149.002 1.00 58.88  ? 282 PHE A CZ  1 
ATOM   2083 N N   . VAL A 1 257 ? 157.396 145.330 145.273 1.00 45.63  ? 283 VAL A N   1 
ATOM   2084 C CA  . VAL A 1 257 ? 156.129 144.687 144.949 1.00 43.92  ? 283 VAL A CA  1 
ATOM   2085 C C   . VAL A 1 257 ? 156.232 143.180 145.133 1.00 55.80  ? 283 VAL A C   1 
ATOM   2086 O O   . VAL A 1 257 ? 155.322 142.547 145.683 1.00 63.72  ? 283 VAL A O   1 
ATOM   2087 C CB  . VAL A 1 257 ? 155.699 145.060 143.520 1.00 47.12  ? 283 VAL A CB  1 
ATOM   2088 C CG1 . VAL A 1 257 ? 154.641 144.103 143.008 1.00 53.33  ? 283 VAL A CG1 1 
ATOM   2089 C CG2 . VAL A 1 257 ? 155.177 146.478 143.486 1.00 46.50  ? 283 VAL A CG2 1 
ATOM   2090 N N   . SER A 1 258 ? 157.337 142.579 144.685 1.00 52.15  ? 284 SER A N   1 
ATOM   2091 C CA  . SER A 1 258 ? 157.499 141.139 144.834 1.00 51.55  ? 284 SER A CA  1 
ATOM   2092 C C   . SER A 1 258 ? 157.564 140.739 146.300 1.00 57.83  ? 284 SER A C   1 
ATOM   2093 O O   . SER A 1 258 ? 156.920 139.765 146.712 1.00 63.84  ? 284 SER A O   1 
ATOM   2094 C CB  . SER A 1 258 ? 158.750 140.675 144.091 1.00 51.74  ? 284 SER A CB  1 
ATOM   2095 O OG  . SER A 1 258 ? 158.673 141.001 142.715 1.00 54.89  ? 284 SER A OG  1 
ATOM   2096 N N   . TYR A 1 259 ? 158.317 141.489 147.110 1.00 55.43  ? 285 TYR A N   1 
ATOM   2097 C CA  . TYR A 1 259 ? 158.388 141.176 148.534 1.00 52.34  ? 285 TYR A CA  1 
ATOM   2098 C C   . TYR A 1 259 ? 157.025 141.318 149.199 1.00 53.33  ? 285 TYR A C   1 
ATOM   2099 O O   . TYR A 1 259 ? 156.604 140.440 149.966 1.00 62.93  ? 285 TYR A O   1 
ATOM   2100 C CB  . TYR A 1 259 ? 159.417 142.077 149.213 1.00 52.99  ? 285 TYR A CB  1 
ATOM   2101 C CG  . TYR A 1 259 ? 159.570 141.834 150.694 1.00 55.92  ? 285 TYR A CG  1 
ATOM   2102 C CD1 . TYR A 1 259 ? 160.272 140.736 151.167 1.00 57.64  ? 285 TYR A CD1 1 
ATOM   2103 C CD2 . TYR A 1 259 ? 159.024 142.711 151.620 1.00 58.72  ? 285 TYR A CD2 1 
ATOM   2104 C CE1 . TYR A 1 259 ? 160.418 140.512 152.521 1.00 62.53  ? 285 TYR A CE1 1 
ATOM   2105 C CE2 . TYR A 1 259 ? 159.164 142.497 152.975 1.00 60.65  ? 285 TYR A CE2 1 
ATOM   2106 C CZ  . TYR A 1 259 ? 159.862 141.396 153.421 1.00 64.37  ? 285 TYR A CZ  1 
ATOM   2107 O OH  . TYR A 1 259 ? 160.006 141.179 154.771 1.00 63.53  ? 285 TYR A OH  1 
ATOM   2108 N N   . PHE A 1 260 ? 156.313 142.407 148.899 1.00 43.80  ? 286 PHE A N   1 
ATOM   2109 C CA  . PHE A 1 260 ? 155.009 142.641 149.508 1.00 43.56  ? 286 PHE A CA  1 
ATOM   2110 C C   . PHE A 1 260 ? 154.015 141.557 149.119 1.00 46.03  ? 286 PHE A C   1 
ATOM   2111 O O   . PHE A 1 260 ? 153.255 141.073 149.965 1.00 56.74  ? 286 PHE A O   1 
ATOM   2112 C CB  . PHE A 1 260 ? 154.495 144.022 149.105 1.00 44.35  ? 286 PHE A CB  1 
ATOM   2113 C CG  . PHE A 1 260 ? 153.115 144.331 149.606 1.00 47.04  ? 286 PHE A CG  1 
ATOM   2114 C CD1 . PHE A 1 260 ? 152.808 144.220 150.949 1.00 50.79  ? 286 PHE A CD1 1 
ATOM   2115 C CD2 . PHE A 1 260 ? 152.130 144.759 148.733 1.00 48.49  ? 286 PHE A CD2 1 
ATOM   2116 C CE1 . PHE A 1 260 ? 151.539 144.512 151.409 1.00 54.22  ? 286 PHE A CE1 1 
ATOM   2117 C CE2 . PHE A 1 260 ? 150.863 145.054 149.186 1.00 46.96  ? 286 PHE A CE2 1 
ATOM   2118 C CZ  . PHE A 1 260 ? 150.566 144.932 150.525 1.00 50.58  ? 286 PHE A CZ  1 
ATOM   2119 N N   . HIS A 1 261 ? 154.024 141.138 147.853 1.00 43.31  ? 287 HIS A N   1 
ATOM   2120 C CA  . HIS A 1 261 ? 153.056 140.142 147.415 1.00 42.96  ? 287 HIS A CA  1 
ATOM   2121 C C   . HIS A 1 261 ? 153.399 138.753 147.932 1.00 47.83  ? 287 HIS A C   1 
ATOM   2122 O O   . HIS A 1 261 ? 152.491 137.979 148.250 1.00 58.10  ? 287 HIS A O   1 
ATOM   2123 C CB  . HIS A 1 261 ? 152.952 140.146 145.894 1.00 45.04  ? 287 HIS A CB  1 
ATOM   2124 C CG  . HIS A 1 261 ? 152.144 141.284 145.355 1.00 48.37  ? 287 HIS A CG  1 
ATOM   2125 N ND1 . HIS A 1 261 ? 151.046 141.792 146.014 1.00 49.21  ? 287 HIS A ND1 1 
ATOM   2126 C CD2 . HIS A 1 261 ? 152.276 142.017 144.225 1.00 47.50  ? 287 HIS A CD2 1 
ATOM   2127 C CE1 . HIS A 1 261 ? 150.535 142.786 145.312 1.00 48.50  ? 287 HIS A CE1 1 
ATOM   2128 N NE2 . HIS A 1 261 ? 151.264 142.945 144.223 1.00 47.77  ? 287 HIS A NE2 1 
ATOM   2129 N N   . CYS A 1 262 ? 154.687 138.420 148.055 1.00 50.62  ? 288 CYS A N   1 
ATOM   2130 C CA  . CYS A 1 262 ? 155.042 137.150 148.679 1.00 48.37  ? 288 CYS A CA  1 
ATOM   2131 C C   . CYS A 1 262 ? 154.622 137.123 150.143 1.00 51.95  ? 288 CYS A C   1 
ATOM   2132 O O   . CYS A 1 262 ? 154.074 136.119 150.623 1.00 54.95  ? 288 CYS A O   1 
ATOM   2133 C CB  . CYS A 1 262 ? 156.541 136.895 148.542 1.00 46.95  ? 288 CYS A CB  1 
ATOM   2134 S SG  . CYS A 1 262 ? 157.091 136.575 146.854 1.00 62.31  ? 288 CYS A SG  1 
ATOM   2135 N N   . MET A 1 263 ? 154.853 138.222 150.866 1.00 55.85  ? 289 MET A N   1 
ATOM   2136 C CA  . MET A 1 263 ? 154.440 138.267 152.263 1.00 53.72  ? 289 MET A CA  1 
ATOM   2137 C C   . MET A 1 263 ? 152.924 138.200 152.398 1.00 54.99  ? 289 MET A C   1 
ATOM   2138 O O   . MET A 1 263 ? 152.409 137.558 153.318 1.00 65.69  ? 289 MET A O   1 
ATOM   2139 C CB  . MET A 1 263 ? 154.992 139.521 152.938 1.00 55.84  ? 289 MET A CB  1 
ATOM   2140 C CG  . MET A 1 263 ? 155.996 139.222 154.037 1.00 59.94  ? 289 MET A CG  1 
ATOM   2141 S SD  . MET A 1 263 ? 156.535 140.690 154.929 1.00 77.30  ? 289 MET A SD  1 
ATOM   2142 C CE  . MET A 1 263 ? 157.445 139.946 156.280 1.00 65.71  ? 289 MET A CE  1 
ATOM   2143 N N   . ASN A 1 264 ? 152.188 138.849 151.491 1.00 49.05  ? 290 ASN A N   1 
ATOM   2144 C CA  . ASN A 1 264 ? 150.732 138.771 151.546 1.00 48.07  ? 290 ASN A CA  1 
ATOM   2145 C C   . ASN A 1 264 ? 150.230 137.376 151.205 1.00 46.01  ? 290 ASN A C   1 
ATOM   2146 O O   . ASN A 1 264 ? 149.235 136.920 151.779 1.00 52.47  ? 290 ASN A O   1 
ATOM   2147 C CB  . ASN A 1 264 ? 150.107 139.800 150.607 1.00 51.87  ? 290 ASN A CB  1 
ATOM   2148 C CG  . ASN A 1 264 ? 150.070 141.185 151.206 1.00 56.24  ? 290 ASN A CG  1 
ATOM   2149 O OD1 . ASN A 1 264 ? 150.814 141.490 152.138 1.00 56.56  ? 290 ASN A OD1 1 
ATOM   2150 N ND2 . ASN A 1 264 ? 149.198 142.034 150.678 1.00 55.04  ? 290 ASN A ND2 1 
ATOM   2151 N N   . SER A 1 265 ? 150.894 136.690 150.274 1.00 46.00  ? 291 SER A N   1 
ATOM   2152 C CA  . SER A 1 265 ? 150.514 135.320 149.956 1.00 48.57  ? 291 SER A CA  1 
ATOM   2153 C C   . SER A 1 265 ? 150.735 134.400 151.147 1.00 54.22  ? 291 SER A C   1 
ATOM   2154 O O   . SER A 1 265 ? 149.907 133.524 151.424 1.00 60.01  ? 291 SER A O   1 
ATOM   2155 C CB  . SER A 1 265 ? 151.303 134.825 148.745 1.00 52.72  ? 291 SER A CB  1 
ATOM   2156 O OG  . SER A 1 265 ? 151.021 133.463 148.476 1.00 57.44  ? 291 SER A OG  1 
ATOM   2157 N N   . GLN A 1 266 ? 151.844 134.582 151.865 1.00 57.66  ? 292 GLN A N   1 
ATOM   2158 C CA  . GLN A 1 266 ? 152.125 133.699 152.993 1.00 50.71  ? 292 GLN A CA  1 
ATOM   2159 C C   . GLN A 1 266 ? 151.271 134.030 154.213 1.00 47.53  ? 292 GLN A C   1 
ATOM   2160 O O   . GLN A 1 266 ? 150.849 133.123 154.939 1.00 50.34  ? 292 GLN A O   1 
ATOM   2161 C CB  . GLN A 1 266 ? 153.610 133.755 153.345 1.00 51.18  ? 292 GLN A CB  1 
ATOM   2162 C CG  . GLN A 1 266 ? 154.501 133.123 152.295 1.00 54.96  ? 292 GLN A CG  1 
ATOM   2163 C CD  . GLN A 1 266 ? 154.119 131.686 152.004 1.00 56.94  ? 292 GLN A CD  1 
ATOM   2164 O OE1 . GLN A 1 266 ? 153.783 130.925 152.910 1.00 56.87  ? 292 GLN A OE1 1 
ATOM   2165 N NE2 . GLN A 1 266 ? 154.166 131.308 150.732 1.00 55.81  ? 292 GLN A NE2 1 
ATOM   2166 N N   . LEU A 1 267 ? 151.004 135.315 154.460 1.00 50.13  ? 293 LEU A N   1 
ATOM   2167 C CA  . LEU A 1 267 ? 150.287 135.699 155.673 1.00 46.90  ? 293 LEU A CA  1 
ATOM   2168 C C   . LEU A 1 267 ? 148.802 135.369 155.584 1.00 50.24  ? 293 LEU A C   1 
ATOM   2169 O O   . LEU A 1 267 ? 148.218 134.858 156.546 1.00 55.84  ? 293 LEU A O   1 
ATOM   2170 C CB  . LEU A 1 267 ? 150.479 137.188 155.949 1.00 48.91  ? 293 LEU A CB  1 
ATOM   2171 C CG  . LEU A 1 267 ? 151.852 137.643 156.440 1.00 52.54  ? 293 LEU A CG  1 
ATOM   2172 C CD1 . LEU A 1 267 ? 151.873 139.149 156.613 1.00 54.20  ? 293 LEU A CD1 1 
ATOM   2173 C CD2 . LEU A 1 267 ? 152.213 136.950 157.738 1.00 55.44  ? 293 LEU A CD2 1 
ATOM   2174 N N   . PHE A 1 268 ? 148.174 135.652 154.450 1.00 56.73  ? 294 PHE A N   1 
ATOM   2175 C CA  . PHE A 1 268 ? 146.735 135.510 154.295 1.00 53.82  ? 294 PHE A CA  1 
ATOM   2176 C C   . PHE A 1 268 ? 146.407 134.308 153.415 1.00 60.35  ? 294 PHE A C   1 
ATOM   2177 O O   . PHE A 1 268 ? 147.287 133.654 152.849 1.00 65.59  ? 294 PHE A O   1 
ATOM   2178 C CB  . PHE A 1 268 ? 146.128 136.788 153.715 1.00 53.78  ? 294 PHE A CB  1 
ATOM   2179 C CG  . PHE A 1 268 ? 146.427 138.020 154.516 1.00 56.13  ? 294 PHE A CG  1 
ATOM   2180 C CD1 . PHE A 1 268 ? 145.717 138.302 155.668 1.00 59.10  ? 294 PHE A CD1 1 
ATOM   2181 C CD2 . PHE A 1 268 ? 147.411 138.902 154.110 1.00 59.15  ? 294 PHE A CD2 1 
ATOM   2182 C CE1 . PHE A 1 268 ? 145.988 139.437 156.404 1.00 59.59  ? 294 PHE A CE1 1 
ATOM   2183 C CE2 . PHE A 1 268 ? 147.686 140.039 154.842 1.00 59.99  ? 294 PHE A CE2 1 
ATOM   2184 C CZ  . PHE A 1 268 ? 146.974 140.306 155.990 1.00 60.02  ? 294 PHE A CZ  1 
ATOM   2185 N N   . SER A 1 269 ? 145.112 134.026 153.306 1.00 53.32  ? 295 SER A N   1 
ATOM   2186 C CA  . SER A 1 269 ? 144.580 132.944 152.488 1.00 55.27  ? 295 SER A CA  1 
ATOM   2187 C C   . SER A 1 269 ? 143.686 133.496 151.384 1.00 54.85  ? 295 SER A C   1 
ATOM   2188 O O   . SER A 1 269 ? 142.620 132.952 151.090 1.00 56.97  ? 295 SER A O   1 
ATOM   2189 C CB  . SER A 1 269 ? 143.817 131.938 153.344 1.00 58.46  ? 295 SER A CB  1 
ATOM   2190 O OG  . SER A 1 269 ? 142.722 132.554 153.998 1.00 63.58  ? 295 SER A OG  1 
ATOM   2191 N N   . ILE A 1 270 ? 144.115 134.597 150.765 1.00 51.73  ? 296 ILE A N   1 
ATOM   2192 C CA  . ILE A 1 270 ? 143.307 135.231 149.730 1.00 49.21  ? 296 ILE A CA  1 
ATOM   2193 C C   . ILE A 1 270 ? 143.192 134.340 148.500 1.00 54.08  ? 296 ILE A C   1 
ATOM   2194 O O   . ILE A 1 270 ? 142.156 134.337 147.825 1.00 54.89  ? 296 ILE A O   1 
ATOM   2195 C CB  . ILE A 1 270 ? 143.884 136.615 149.381 1.00 47.27  ? 296 ILE A CB  1 
ATOM   2196 C CG1 . ILE A 1 270 ? 145.384 136.521 149.110 1.00 51.07  ? 296 ILE A CG1 1 
ATOM   2197 C CG2 . ILE A 1 270 ? 143.614 137.599 150.503 1.00 50.47  ? 296 ILE A CG2 1 
ATOM   2198 C CD1 . ILE A 1 270 ? 146.036 137.860 148.847 1.00 51.88  ? 296 ILE A CD1 1 
ATOM   2199 N N   . GLY A 1 271 ? 144.234 133.578 148.184 1.00 57.95  ? 297 GLY A N   1 
ATOM   2200 C CA  . GLY A 1 271 ? 144.177 132.656 147.067 1.00 56.33  ? 297 GLY A CA  1 
ATOM   2201 C C   . GLY A 1 271 ? 145.225 132.920 146.007 1.00 62.76  ? 297 GLY A C   1 
ATOM   2202 O O   . GLY A 1 271 ? 146.426 132.869 146.286 1.00 67.10  ? 297 GLY A O   1 
ATOM   2203 N N   . MET A 1 272 ? 144.782 133.203 144.783 1.00 52.72  ? 298 MET A N   1 
ATOM   2204 C CA  . MET A 1 272 ? 145.677 133.469 143.666 1.00 51.00  ? 298 MET A CA  1 
ATOM   2205 C C   . MET A 1 272 ? 145.851 134.956 143.395 1.00 53.38  ? 298 MET A C   1 
ATOM   2206 O O   . MET A 1 272 ? 146.432 135.323 142.370 1.00 59.64  ? 298 MET A O   1 
ATOM   2207 C CB  . MET A 1 272 ? 145.167 132.770 142.405 1.00 51.84  ? 298 MET A CB  1 
ATOM   2208 C CG  . MET A 1 272 ? 145.031 131.264 142.532 1.00 50.32  ? 298 MET A CG  1 
ATOM   2209 S SD  . MET A 1 272 ? 146.612 130.425 142.702 1.00 66.39  ? 298 MET A SD  1 
ATOM   2210 C CE  . MET A 1 272 ? 146.079 128.719 142.754 1.00 57.21  ? 298 MET A CE  1 
ATOM   2211 N N   . PHE A 1 273 ? 145.364 135.818 144.290 1.00 44.02  ? 299 PHE A N   1 
ATOM   2212 C CA  . PHE A 1 273 ? 145.459 137.257 144.067 1.00 43.16  ? 299 PHE A CA  1 
ATOM   2213 C C   . PHE A 1 273 ? 146.911 137.715 144.011 1.00 52.09  ? 299 PHE A C   1 
ATOM   2214 O O   . PHE A 1 273 ? 147.293 138.483 143.117 1.00 58.77  ? 299 PHE A O   1 
ATOM   2215 C CB  . PHE A 1 273 ? 144.697 137.999 145.165 1.00 44.53  ? 299 PHE A CB  1 
ATOM   2216 C CG  . PHE A 1 273 ? 144.741 139.493 145.039 1.00 46.20  ? 299 PHE A CG  1 
ATOM   2217 C CD1 . PHE A 1 273 ? 144.301 140.117 143.887 1.00 47.13  ? 299 PHE A CD1 1 
ATOM   2218 C CD2 . PHE A 1 273 ? 145.203 140.274 146.081 1.00 48.06  ? 299 PHE A CD2 1 
ATOM   2219 C CE1 . PHE A 1 273 ? 144.333 141.491 143.774 1.00 50.40  ? 299 PHE A CE1 1 
ATOM   2220 C CE2 . PHE A 1 273 ? 145.239 141.647 145.972 1.00 49.06  ? 299 PHE A CE2 1 
ATOM   2221 C CZ  . PHE A 1 273 ? 144.803 142.256 144.817 1.00 53.76  ? 299 PHE A CZ  1 
ATOM   2222 N N   . SER A 1 274 ? 147.738 137.237 144.942 1.00 48.77  ? 300 SER A N   1 
ATOM   2223 C CA  . SER A 1 274 ? 149.135 137.652 144.975 1.00 47.64  ? 300 SER A CA  1 
ATOM   2224 C C   . SER A 1 274 ? 149.877 137.193 143.728 1.00 51.21  ? 300 SER A C   1 
ATOM   2225 O O   . SER A 1 274 ? 150.693 137.938 143.173 1.00 54.81  ? 300 SER A O   1 
ATOM   2226 C CB  . SER A 1 274 ? 149.809 137.111 146.233 1.00 47.27  ? 300 SER A CB  1 
ATOM   2227 O OG  . SER A 1 274 ? 151.192 137.412 146.239 1.00 55.11  ? 300 SER A OG  1 
ATOM   2228 N N   . TYR A 1 275 ? 149.593 135.977 143.260 1.00 50.45  ? 301 TYR A N   1 
ATOM   2229 C CA  . TYR A 1 275 ? 150.266 135.472 142.070 1.00 46.05  ? 301 TYR A CA  1 
ATOM   2230 C C   . TYR A 1 275 ? 149.815 136.207 140.815 1.00 49.00  ? 301 TYR A C   1 
ATOM   2231 O O   . TYR A 1 275 ? 150.633 136.465 139.925 1.00 57.95  ? 301 TYR A O   1 
ATOM   2232 C CB  . TYR A 1 275 ? 150.028 133.971 141.937 1.00 50.29  ? 301 TYR A CB  1 
ATOM   2233 C CG  . TYR A 1 275 ? 150.391 133.199 143.184 1.00 54.68  ? 301 TYR A CG  1 
ATOM   2234 C CD1 . TYR A 1 275 ? 151.706 132.847 143.446 1.00 54.80  ? 301 TYR A CD1 1 
ATOM   2235 C CD2 . TYR A 1 275 ? 149.419 132.830 144.102 1.00 55.41  ? 301 TYR A CD2 1 
ATOM   2236 C CE1 . TYR A 1 275 ? 152.042 132.146 144.585 1.00 52.24  ? 301 TYR A CE1 1 
ATOM   2237 C CE2 . TYR A 1 275 ? 149.746 132.129 145.243 1.00 52.67  ? 301 TYR A CE2 1 
ATOM   2238 C CZ  . TYR A 1 275 ? 151.058 131.790 145.480 1.00 52.31  ? 301 TYR A CZ  1 
ATOM   2239 O OH  . TYR A 1 275 ? 151.387 131.090 146.618 1.00 56.61  ? 301 TYR A OH  1 
ATOM   2240 N N   . VAL A 1 276 ? 148.533 136.567 140.727 1.00 43.83  ? 302 VAL A N   1 
ATOM   2241 C CA  . VAL A 1 276 ? 148.066 137.356 139.591 1.00 43.74  ? 302 VAL A CA  1 
ATOM   2242 C C   . VAL A 1 276 ? 148.724 138.730 139.590 1.00 51.34  ? 302 VAL A C   1 
ATOM   2243 O O   . VAL A 1 276 ? 149.131 139.237 138.537 1.00 55.22  ? 302 VAL A O   1 
ATOM   2244 C CB  . VAL A 1 276 ? 146.530 137.462 139.603 1.00 47.70  ? 302 VAL A CB  1 
ATOM   2245 C CG1 . VAL A 1 276 ? 146.060 138.470 138.571 1.00 54.17  ? 302 VAL A CG1 1 
ATOM   2246 C CG2 . VAL A 1 276 ? 145.901 136.109 139.335 1.00 45.98  ? 302 VAL A CG2 1 
ATOM   2247 N N   . MET A 1 277 ? 148.843 139.357 140.764 1.00 46.39  ? 303 MET A N   1 
ATOM   2248 C CA  . MET A 1 277 ? 149.507 140.655 140.826 1.00 45.30  ? 303 MET A CA  1 
ATOM   2249 C C   . MET A 1 277 ? 150.984 140.543 140.458 1.00 46.37  ? 303 MET A C   1 
ATOM   2250 O O   . MET A 1 277 ? 151.525 141.413 139.764 1.00 52.73  ? 303 MET A O   1 
ATOM   2251 C CB  . MET A 1 277 ? 149.338 141.267 142.215 1.00 45.11  ? 303 MET A CB  1 
ATOM   2252 C CG  . MET A 1 277 ? 147.893 141.540 142.603 1.00 46.75  ? 303 MET A CG  1 
ATOM   2253 S SD  . MET A 1 277 ? 147.042 142.672 141.488 1.00 55.81  ? 303 MET A SD  1 
ATOM   2254 C CE  . MET A 1 277 ? 147.943 144.187 141.789 1.00 49.58  ? 303 MET A CE  1 
ATOM   2255 N N   . LEU A 1 278 ? 151.652 139.477 140.907 1.00 43.29  ? 304 LEU A N   1 
ATOM   2256 C CA  . LEU A 1 278 ? 153.044 139.265 140.525 1.00 38.42  ? 304 LEU A CA  1 
ATOM   2257 C C   . LEU A 1 278 ? 153.181 139.050 139.024 1.00 41.89  ? 304 LEU A C   1 
ATOM   2258 O O   . LEU A 1 278 ? 154.151 139.509 138.413 1.00 46.36  ? 304 LEU A O   1 
ATOM   2259 C CB  . LEU A 1 278 ? 153.629 138.078 141.290 1.00 40.92  ? 304 LEU A CB  1 
ATOM   2260 C CG  . LEU A 1 278 ? 154.156 138.384 142.688 1.00 42.80  ? 304 LEU A CG  1 
ATOM   2261 C CD1 . LEU A 1 278 ? 154.778 137.148 143.310 1.00 43.88  ? 304 LEU A CD1 1 
ATOM   2262 C CD2 . LEU A 1 278 ? 155.164 139.513 142.621 1.00 47.00  ? 304 LEU A CD2 1 
ATOM   2263 N N   . ALA A 1 279 ? 152.227 138.343 138.416 1.00 39.46  ? 305 ALA A N   1 
ATOM   2264 C CA  . ALA A 1 279 ? 152.267 138.133 136.974 1.00 42.42  ? 305 ALA A CA  1 
ATOM   2265 C C   . ALA A 1 279 ? 152.007 139.423 136.210 1.00 39.18  ? 305 ALA A C   1 
ATOM   2266 O O   . ALA A 1 279 ? 152.555 139.617 135.119 1.00 41.86  ? 305 ALA A O   1 
ATOM   2267 C CB  . ALA A 1 279 ? 151.251 137.066 136.571 1.00 45.07  ? 305 ALA A CB  1 
ATOM   2268 N N   . SER A 1 280 ? 151.168 140.305 136.751 1.00 38.97  ? 306 SER A N   1 
ATOM   2269 C CA  . SER A 1 280 ? 150.887 141.577 136.098 1.00 41.52  ? 306 SER A CA  1 
ATOM   2270 C C   . SER A 1 280 ? 151.959 142.627 136.350 1.00 40.01  ? 306 SER A C   1 
ATOM   2271 O O   . SER A 1 280 ? 151.986 143.640 135.644 1.00 49.25  ? 306 SER A O   1 
ATOM   2272 C CB  . SER A 1 280 ? 149.532 142.117 136.558 1.00 47.92  ? 306 SER A CB  1 
ATOM   2273 O OG  . SER A 1 280 ? 149.542 142.399 137.946 1.00 51.49  ? 306 SER A OG  1 
ATOM   2274 N N   . SER A 1 281 ? 152.824 142.420 137.342 1.00 42.86  ? 307 SER A N   1 
ATOM   2275 C CA  . SER A 1 281 ? 153.892 143.385 137.599 1.00 46.87  ? 307 SER A CA  1 
ATOM   2276 C C   . SER A 1 281 ? 154.835 143.604 136.416 1.00 45.61  ? 307 SER A C   1 
ATOM   2277 O O   . SER A 1 281 ? 155.159 144.773 136.142 1.00 46.26  ? 307 SER A O   1 
ATOM   2278 C CB  . SER A 1 281 ? 154.679 142.964 138.847 1.00 50.06  ? 307 SER A CB  1 
ATOM   2279 O OG  . SER A 1 281 ? 153.841 142.925 139.989 1.00 57.08  ? 307 SER A OG  1 
ATOM   2280 N N   . PRO A 1 282 ? 155.308 142.586 135.692 1.00 38.13  ? 308 PRO A N   1 
ATOM   2281 C CA  . PRO A 1 282 ? 156.228 142.837 134.576 1.00 31.23  ? 308 PRO A CA  1 
ATOM   2282 C C   . PRO A 1 282 ? 155.588 143.467 133.350 1.00 39.22  ? 308 PRO A C   1 
ATOM   2283 O O   . PRO A 1 282 ? 156.273 143.630 132.337 1.00 49.74  ? 308 PRO A O   1 
ATOM   2284 C CB  . PRO A 1 282 ? 156.753 141.430 134.239 1.00 32.24  ? 308 PRO A CB  1 
ATOM   2285 C CG  . PRO A 1 282 ? 156.487 140.614 135.440 1.00 40.35  ? 308 PRO A CG  1 
ATOM   2286 C CD  . PRO A 1 282 ? 155.205 141.144 135.973 1.00 44.30  ? 308 PRO A CD  1 
ATOM   2287 N N   . LEU A 1 283 ? 154.304 143.824 133.407 1.00 41.64  ? 309 LEU A N   1 
ATOM   2288 C CA  . LEU A 1 283 ? 153.655 144.447 132.261 1.00 38.13  ? 309 LEU A CA  1 
ATOM   2289 C C   . LEU A 1 283 ? 154.137 145.871 132.027 1.00 39.68  ? 309 LEU A C   1 
ATOM   2290 O O   . LEU A 1 283 ? 153.930 146.409 130.934 1.00 45.87  ? 309 LEU A O   1 
ATOM   2291 C CB  . LEU A 1 283 ? 152.139 144.431 132.454 1.00 36.31  ? 309 LEU A CB  1 
ATOM   2292 C CG  . LEU A 1 283 ? 151.308 143.899 131.291 1.00 41.61  ? 309 LEU A CG  1 
ATOM   2293 C CD1 . LEU A 1 283 ? 151.855 142.571 130.810 1.00 40.62  ? 309 LEU A CD1 1 
ATOM   2294 C CD2 . LEU A 1 283 ? 149.866 143.748 131.723 1.00 45.42  ? 309 LEU A CD2 1 
ATOM   2295 N N   . PHE A 1 284 ? 154.775 146.489 133.019 1.00 33.22  ? 310 PHE A N   1 
ATOM   2296 C CA  . PHE A 1 284 ? 155.262 147.856 132.893 1.00 35.56  ? 310 PHE A CA  1 
ATOM   2297 C C   . PHE A 1 284 ? 156.617 147.949 132.207 1.00 40.13  ? 310 PHE A C   1 
ATOM   2298 O O   . PHE A 1 284 ? 157.085 149.062 131.950 1.00 44.81  ? 310 PHE A O   1 
ATOM   2299 C CB  . PHE A 1 284 ? 155.345 148.515 134.271 1.00 33.99  ? 310 PHE A CB  1 
ATOM   2300 C CG  . PHE A 1 284 ? 154.009 148.810 134.881 1.00 35.66  ? 310 PHE A CG  1 
ATOM   2301 C CD1 . PHE A 1 284 ? 153.323 147.839 135.586 1.00 40.16  ? 310 PHE A CD1 1 
ATOM   2302 C CD2 . PHE A 1 284 ? 153.440 150.064 134.754 1.00 32.88  ? 310 PHE A CD2 1 
ATOM   2303 C CE1 . PHE A 1 284 ? 152.096 148.111 136.149 1.00 38.28  ? 310 PHE A CE1 1 
ATOM   2304 C CE2 . PHE A 1 284 ? 152.213 150.340 135.316 1.00 35.61  ? 310 PHE A CE2 1 
ATOM   2305 C CZ  . PHE A 1 284 ? 151.541 149.363 136.014 1.00 35.28  ? 310 PHE A CZ  1 
ATOM   2306 N N   . CYS A 1 285 ? 157.256 146.822 131.907 1.00 42.12  ? 311 CYS A N   1 
ATOM   2307 C CA  . CYS A 1 285 ? 158.523 146.841 131.196 1.00 44.22  ? 311 CYS A CA  1 
ATOM   2308 C C   . CYS A 1 285 ? 158.282 147.113 129.714 1.00 43.77  ? 311 CYS A C   1 
ATOM   2309 O O   . CYS A 1 285 ? 157.155 147.349 129.270 1.00 45.59  ? 311 CYS A O   1 
ATOM   2310 C CB  . CYS A 1 285 ? 159.269 145.525 131.402 1.00 45.37  ? 311 CYS A CB  1 
ATOM   2311 S SG  . CYS A 1 285 ? 159.859 145.238 133.084 1.00 40.84  ? 311 CYS A SG  1 
ATOM   2312 N N   . SER A 1 286 ? 159.359 147.088 128.935 1.00 46.95  ? 312 SER A N   1 
ATOM   2313 C CA  . SER A 1 286 ? 159.232 147.252 127.500 1.00 40.37  ? 312 SER A CA  1 
ATOM   2314 C C   . SER A 1 286 ? 158.451 146.079 126.912 1.00 43.39  ? 312 SER A C   1 
ATOM   2315 O O   . SER A 1 286 ? 158.567 144.945 127.385 1.00 52.23  ? 312 SER A O   1 
ATOM   2316 C CB  . SER A 1 286 ? 160.608 147.346 126.847 1.00 40.61  ? 312 SER A CB  1 
ATOM   2317 O OG  . SER A 1 286 ? 161.393 146.206 127.146 1.00 50.31  ? 312 SER A OG  1 
ATOM   2318 N N   . PRO A 1 287 ? 157.641 146.324 125.878 1.00 33.40  ? 313 PRO A N   1 
ATOM   2319 C CA  . PRO A 1 287 ? 156.788 145.257 125.340 1.00 31.21  ? 313 PRO A CA  1 
ATOM   2320 C C   . PRO A 1 287 ? 157.548 144.160 124.619 1.00 42.63  ? 313 PRO A C   1 
ATOM   2321 O O   . PRO A 1 287 ? 156.915 143.239 124.092 1.00 55.10  ? 313 PRO A O   1 
ATOM   2322 C CB  . PRO A 1 287 ? 155.862 146.008 124.369 1.00 38.32  ? 313 PRO A CB  1 
ATOM   2323 C CG  . PRO A 1 287 ? 155.954 147.441 124.769 1.00 40.80  ? 313 PRO A CG  1 
ATOM   2324 C CD  . PRO A 1 287 ? 157.349 147.624 125.258 1.00 44.07  ? 313 PRO A CD  1 
ATOM   2325 N N   . GLU A 1 288 ? 158.878 144.221 124.576 1.00 49.15  ? 314 GLU A N   1 
ATOM   2326 C CA  . GLU A 1 288 ? 159.687 143.193 123.934 1.00 52.35  ? 314 GLU A CA  1 
ATOM   2327 C C   . GLU A 1 288 ? 160.640 142.520 124.914 1.00 52.44  ? 314 GLU A C   1 
ATOM   2328 O O   . GLU A 1 288 ? 161.655 141.956 124.496 1.00 59.99  ? 314 GLU A O   1 
ATOM   2329 C CB  . GLU A 1 288 ? 160.464 143.786 122.758 1.00 51.76  ? 314 GLU A CB  1 
ATOM   2330 C CG  . GLU A 1 288 ? 161.330 144.976 123.132 1.00 54.96  ? 314 GLU A CG  1 
ATOM   2331 C CD  . GLU A 1 288 ? 161.919 145.675 121.922 1.00 61.02  ? 314 GLU A CD  1 
ATOM   2332 O OE1 . GLU A 1 288 ? 161.617 145.256 120.785 1.00 61.35  ? 314 GLU A OE1 1 
ATOM   2333 O OE2 . GLU A 1 288 ? 162.683 146.645 122.109 1.00 62.19  ? 314 GLU A OE2 1 
ATOM   2334 N N   . TRP A 1 289 ? 160.339 142.576 126.210 1.00 41.44  ? 315 TRP A N   1 
ATOM   2335 C CA  . TRP A 1 289 ? 161.221 141.951 127.191 1.00 37.45  ? 315 TRP A CA  1 
ATOM   2336 C C   . TRP A 1 289 ? 161.309 140.431 127.070 1.00 42.39  ? 315 TRP A C   1 
ATOM   2337 O O   . TRP A 1 289 ? 162.425 139.902 127.219 1.00 53.29  ? 315 TRP A O   1 
ATOM   2338 C CB  . TRP A 1 289 ? 160.823 142.385 128.612 1.00 41.78  ? 315 TRP A CB  1 
ATOM   2339 C CG  . TRP A 1 289 ? 159.599 141.745 129.183 1.00 47.01  ? 315 TRP A CG  1 
ATOM   2340 C CD1 . TRP A 1 289 ? 158.327 142.234 129.152 1.00 48.75  ? 315 TRP A CD1 1 
ATOM   2341 C CD2 . TRP A 1 289 ? 159.533 140.501 129.889 1.00 46.05  ? 315 TRP A CD2 1 
ATOM   2342 N NE1 . TRP A 1 289 ? 157.472 141.369 129.787 1.00 44.68  ? 315 TRP A NE1 1 
ATOM   2343 C CE2 . TRP A 1 289 ? 158.188 140.296 130.247 1.00 39.53  ? 315 TRP A CE2 1 
ATOM   2344 C CE3 . TRP A 1 289 ? 160.480 139.538 130.247 1.00 47.61  ? 315 TRP A CE3 1 
ATOM   2345 C CZ2 . TRP A 1 289 ? 157.767 139.171 130.948 1.00 41.21  ? 315 TRP A CZ2 1 
ATOM   2346 C CZ3 . TRP A 1 289 ? 160.059 138.422 130.941 1.00 44.19  ? 315 TRP A CZ3 1 
ATOM   2347 C CH2 . TRP A 1 289 ? 158.716 138.247 131.284 1.00 41.86  ? 315 TRP A CH2 1 
ATOM   2348 N N   . PRO A 1 290 ? 160.229 139.671 126.829 1.00 47.47  ? 316 PRO A N   1 
ATOM   2349 C CA  . PRO A 1 290 ? 160.393 138.210 126.747 1.00 50.82  ? 316 PRO A CA  1 
ATOM   2350 C C   . PRO A 1 290 ? 161.250 137.762 125.579 1.00 53.96  ? 316 PRO A C   1 
ATOM   2351 O O   . PRO A 1 290 ? 161.783 136.646 125.619 1.00 59.92  ? 316 PRO A O   1 
ATOM   2352 C CB  . PRO A 1 290 ? 158.953 137.696 126.605 1.00 50.36  ? 316 PRO A CB  1 
ATOM   2353 C CG  . PRO A 1 290 ? 158.088 138.833 127.020 1.00 55.94  ? 316 PRO A CG  1 
ATOM   2354 C CD  . PRO A 1 290 ? 158.827 140.044 126.576 1.00 53.71  ? 316 PRO A CD  1 
ATOM   2355 N N   . ARG A 1 291 ? 161.398 138.589 124.544 1.00 55.87  ? 317 ARG A N   1 
ATOM   2356 C CA  . ARG A 1 291 ? 162.171 138.181 123.376 1.00 52.50  ? 317 ARG A CA  1 
ATOM   2357 C C   . ARG A 1 291 ? 163.661 138.125 123.684 1.00 52.92  ? 317 ARG A C   1 
ATOM   2358 O O   . ARG A 1 291 ? 164.363 137.224 123.209 1.00 57.82  ? 317 ARG A O   1 
ATOM   2359 C CB  . ARG A 1 291 ? 161.891 139.128 122.210 1.00 51.10  ? 317 ARG A CB  1 
ATOM   2360 C CG  . ARG A 1 291 ? 162.561 138.728 120.910 1.00 58.28  ? 317 ARG A CG  1 
ATOM   2361 C CD  . ARG A 1 291 ? 161.896 139.390 119.713 1.00 59.59  ? 317 ARG A CD  1 
ATOM   2362 N NE  . ARG A 1 291 ? 160.576 138.834 119.443 1.00 55.62  ? 317 ARG A NE  1 
ATOM   2363 C CZ  . ARG A 1 291 ? 159.433 139.389 119.822 1.00 56.34  ? 317 ARG A CZ  1 
ATOM   2364 N NH1 . ARG A 1 291 ? 159.407 140.530 120.490 1.00 59.66  ? 317 ARG A NH1 1 
ATOM   2365 N NH2 . ARG A 1 291 ? 158.287 138.785 119.521 1.00 54.24  ? 317 ARG A NH2 1 
ATOM   2366 N N   . LYS A 1 292 ? 164.166 139.073 124.476 1.00 53.40  ? 318 LYS A N   1 
ATOM   2367 C CA  . LYS A 1 292 ? 165.589 139.086 124.795 1.00 55.82  ? 318 LYS A CA  1 
ATOM   2368 C C   . LYS A 1 292 ? 165.973 138.004 125.793 1.00 56.76  ? 318 LYS A C   1 
ATOM   2369 O O   . LYS A 1 292 ? 167.147 137.624 125.853 1.00 61.05  ? 318 LYS A O   1 
ATOM   2370 C CB  . LYS A 1 292 ? 166.004 140.456 125.337 1.00 54.32  ? 318 LYS A CB  1 
ATOM   2371 C CG  . LYS A 1 292 ? 165.453 140.781 126.713 1.00 57.52  ? 318 LYS A CG  1 
ATOM   2372 C CD  . LYS A 1 292 ? 165.936 142.140 127.193 1.00 61.66  ? 318 LYS A CD  1 
ATOM   2373 C CE  . LYS A 1 292 ? 165.394 142.464 128.575 1.00 58.79  ? 318 LYS A CE  1 
ATOM   2374 N NZ  . LYS A 1 292 ? 165.871 143.789 129.060 1.00 60.57  ? 318 LYS A NZ  1 
ATOM   2375 N N   . LEU A 1 293 ? 165.016 137.501 126.576 1.00 65.99  ? 319 LEU A N   1 
ATOM   2376 C CA  . LEU A 1 293 ? 165.302 136.367 127.448 1.00 71.34  ? 319 LEU A CA  1 
ATOM   2377 C C   . LEU A 1 293 ? 165.536 135.099 126.639 1.00 72.18  ? 319 LEU A C   1 
ATOM   2378 O O   . LEU A 1 293 ? 166.410 134.291 126.976 1.00 72.38  ? 319 LEU A O   1 
ATOM   2379 C CB  . LEU A 1 293 ? 164.159 136.169 128.443 1.00 73.24  ? 319 LEU A CB  1 
ATOM   2380 C CG  . LEU A 1 293 ? 164.302 135.003 129.422 1.00 73.13  ? 319 LEU A CG  1 
ATOM   2381 C CD1 . LEU A 1 293 ? 165.535 135.183 130.295 1.00 70.04  ? 319 LEU A CD1 1 
ATOM   2382 C CD2 . LEU A 1 293 ? 163.052 134.861 130.275 1.00 70.18  ? 319 LEU A CD2 1 
ATOM   2383 N N   . VAL A 1 294 ? 164.759 134.905 125.571 1.00 80.63  ? 320 VAL A N   1 
ATOM   2384 C CA  . VAL A 1 294 ? 164.944 133.738 124.714 1.00 82.27  ? 320 VAL A CA  1 
ATOM   2385 C C   . VAL A 1 294 ? 166.282 133.818 123.988 1.00 85.17  ? 320 VAL A C   1 
ATOM   2386 O O   . VAL A 1 294 ? 167.028 132.834 123.915 1.00 82.65  ? 320 VAL A O   1 
ATOM   2387 C CB  . VAL A 1 294 ? 163.772 133.611 123.725 1.00 78.38  ? 320 VAL A CB  1 
ATOM   2388 C CG1 . VAL A 1 294 ? 163.959 132.394 122.833 1.00 79.67  ? 320 VAL A CG1 1 
ATOM   2389 C CG2 . VAL A 1 294 ? 162.453 133.529 124.476 1.00 77.15  ? 320 VAL A CG2 1 
ATOM   2390 N N   . SER A 1 295 ? 166.607 134.987 123.446 1.00 89.89  ? 321 SER A N   1 
ATOM   2391 C CA  . SER A 1 295 ? 167.859 135.177 122.725 1.00 88.68  ? 321 SER A CA  1 
ATOM   2392 C C   . SER A 1 295 ? 168.961 135.660 123.662 1.00 85.31  ? 321 SER A C   1 
ATOM   2393 O O   . SER A 1 295 ? 170.131 135.320 123.487 1.00 86.75  ? 321 SER A O   1 
ATOM   2394 C CB  . SER A 1 295 ? 167.673 136.169 121.575 1.00 87.81  ? 321 SER A CB  1 
ATOM   2395 O OG  . SER A 1 295 ? 166.683 135.718 120.667 1.00 84.96  ? 321 SER A OG  1 
ATOM   2396 N N   . LYS A 1 329 ? 143.802 158.639 107.212 1.00 86.57  ? 355 LYS A N   1 
ATOM   2397 C CA  . LYS A 1 329 ? 142.602 158.721 108.037 1.00 90.39  ? 355 LYS A CA  1 
ATOM   2398 C C   . LYS A 1 329 ? 142.363 157.424 108.800 1.00 93.06  ? 355 LYS A C   1 
ATOM   2399 O O   . LYS A 1 329 ? 142.264 156.355 108.198 1.00 94.48  ? 355 LYS A O   1 
ATOM   2400 C CB  . LYS A 1 329 ? 141.381 159.052 107.176 1.00 88.70  ? 355 LYS A CB  1 
ATOM   2401 C CG  . LYS A 1 329 ? 140.062 159.005 107.932 1.00 89.20  ? 355 LYS A CG  1 
ATOM   2402 C CD  . LYS A 1 329 ? 138.885 159.300 107.015 1.00 88.15  ? 355 LYS A CD  1 
ATOM   2403 C CE  . LYS A 1 329 ? 137.563 159.155 107.752 1.00 88.23  ? 355 LYS A CE  1 
ATOM   2404 N NZ  . LYS A 1 329 ? 137.480 160.062 108.930 1.00 90.81  ? 355 LYS A NZ  1 
ATOM   2405 N N   . PRO A 1 330 ? 142.277 157.517 110.125 1.00 80.42  ? 356 PRO A N   1 
ATOM   2406 C CA  . PRO A 1 330 ? 141.972 156.328 110.926 1.00 76.83  ? 356 PRO A CA  1 
ATOM   2407 C C   . PRO A 1 330 ? 140.583 155.796 110.618 1.00 77.79  ? 356 PRO A C   1 
ATOM   2408 O O   . PRO A 1 330 ? 139.658 156.546 110.300 1.00 79.44  ? 356 PRO A O   1 
ATOM   2409 C CB  . PRO A 1 330 ? 142.064 156.836 112.370 1.00 77.63  ? 356 PRO A CB  1 
ATOM   2410 C CG  . PRO A 1 330 ? 142.885 158.082 112.290 1.00 76.50  ? 356 PRO A CG  1 
ATOM   2411 C CD  . PRO A 1 330 ? 142.553 158.693 110.965 1.00 77.13  ? 356 PRO A CD  1 
ATOM   2412 N N   . GLY A 1 331 ? 140.447 154.477 110.715 1.00 76.90  ? 357 GLY A N   1 
ATOM   2413 C CA  . GLY A 1 331 ? 139.188 153.830 110.409 1.00 76.44  ? 357 GLY A CA  1 
ATOM   2414 C C   . GLY A 1 331 ? 138.205 153.864 111.559 1.00 77.61  ? 357 GLY A C   1 
ATOM   2415 O O   . GLY A 1 331 ? 138.102 154.868 112.269 1.00 79.99  ? 357 GLY A O   1 
ATOM   2416 N N   . LEU A 1 332 ? 137.475 152.768 111.753 1.00 70.09  ? 358 LEU A N   1 
ATOM   2417 C CA  . LEU A 1 332 ? 136.461 152.674 112.794 1.00 68.35  ? 358 LEU A CA  1 
ATOM   2418 C C   . LEU A 1 332 ? 136.984 152.003 114.057 1.00 73.33  ? 358 LEU A C   1 
ATOM   2419 O O   . LEU A 1 332 ? 136.753 152.499 115.165 1.00 79.83  ? 358 LEU A O   1 
ATOM   2420 C CB  . LEU A 1 332 ? 135.239 151.916 112.267 1.00 70.45  ? 358 LEU A CB  1 
ATOM   2421 C CG  . LEU A 1 332 ? 134.047 151.796 113.215 1.00 74.00  ? 358 LEU A CG  1 
ATOM   2422 C CD1 . LEU A 1 332 ? 133.513 153.173 113.576 1.00 74.59  ? 358 LEU A CD1 1 
ATOM   2423 C CD2 . LEU A 1 332 ? 132.955 150.939 112.594 1.00 73.93  ? 358 LEU A CD2 1 
ATOM   2424 N N   . ARG A 1 333 ? 137.688 150.877 113.912 1.00 74.70  ? 359 ARG A N   1 
ATOM   2425 C CA  . ARG A 1 333 ? 138.209 150.179 115.080 1.00 74.85  ? 359 ARG A CA  1 
ATOM   2426 C C   . ARG A 1 333 ? 139.273 151.001 115.794 1.00 74.56  ? 359 ARG A C   1 
ATOM   2427 O O   . ARG A 1 333 ? 139.402 150.911 117.021 1.00 80.57  ? 359 ARG A O   1 
ATOM   2428 C CB  . ARG A 1 333 ? 138.764 148.815 114.674 1.00 75.04  ? 359 ARG A CB  1 
ATOM   2429 C CG  . ARG A 1 333 ? 139.836 148.867 113.601 1.00 76.92  ? 359 ARG A CG  1 
ATOM   2430 C CD  . ARG A 1 333 ? 140.219 147.471 113.139 1.00 82.08  ? 359 ARG A CD  1 
ATOM   2431 N NE  . ARG A 1 333 ? 140.646 146.626 114.248 1.00 83.92  ? 359 ARG A NE  1 
ATOM   2432 C CZ  . ARG A 1 333 ? 140.988 145.350 114.128 1.00 83.36  ? 359 ARG A CZ  1 
ATOM   2433 N NH1 . ARG A 1 333 ? 140.966 144.735 112.957 1.00 80.19  ? 359 ARG A NH1 1 
ATOM   2434 N NH2 . ARG A 1 333 ? 141.360 144.674 115.212 1.00 79.38  ? 359 ARG A NH2 1 
ATOM   2435 N N   . HIS A 1 334 ? 140.024 151.819 115.054 1.00 58.91  ? 360 HIS A N   1 
ATOM   2436 C CA  . HIS A 1 334 ? 141.039 152.658 115.683 1.00 64.48  ? 360 HIS A CA  1 
ATOM   2437 C C   . HIS A 1 334 ? 140.409 153.674 116.627 1.00 67.89  ? 360 HIS A C   1 
ATOM   2438 O O   . HIS A 1 334 ? 140.947 153.943 117.707 1.00 72.62  ? 360 HIS A O   1 
ATOM   2439 C CB  . HIS A 1 334 ? 141.875 153.361 114.616 1.00 64.55  ? 360 HIS A CB  1 
ATOM   2440 C CG  . HIS A 1 334 ? 142.838 152.459 113.910 1.00 64.31  ? 360 HIS A CG  1 
ATOM   2441 N ND1 . HIS A 1 334 ? 143.815 152.933 113.062 1.00 63.35  ? 360 HIS A ND1 1 
ATOM   2442 C CD2 . HIS A 1 334 ? 142.979 151.113 113.931 1.00 66.01  ? 360 HIS A CD2 1 
ATOM   2443 C CE1 . HIS A 1 334 ? 144.514 151.918 112.588 1.00 64.05  ? 360 HIS A CE1 1 
ATOM   2444 N NE2 . HIS A 1 334 ? 144.027 150.802 113.100 1.00 66.35  ? 360 HIS A NE2 1 
ATOM   2445 N N   . GLN A 1 335 ? 139.270 154.250 116.238 1.00 65.65  ? 361 GLN A N   1 
ATOM   2446 C CA  . GLN A 1 335 ? 138.572 155.175 117.122 1.00 65.06  ? 361 GLN A CA  1 
ATOM   2447 C C   . GLN A 1 335 ? 137.824 154.446 118.229 1.00 65.27  ? 361 GLN A C   1 
ATOM   2448 O O   . GLN A 1 335 ? 137.747 154.949 119.360 1.00 71.49  ? 361 GLN A O   1 
ATOM   2449 C CB  . GLN A 1 335 ? 137.605 156.041 116.313 1.00 66.00  ? 361 GLN A CB  1 
ATOM   2450 C CG  . GLN A 1 335 ? 138.272 156.852 115.215 1.00 68.27  ? 361 GLN A CG  1 
ATOM   2451 C CD  . GLN A 1 335 ? 137.284 157.681 114.421 1.00 70.11  ? 361 GLN A CD  1 
ATOM   2452 O OE1 . GLN A 1 335 ? 136.073 157.482 114.511 1.00 71.44  ? 361 GLN A OE1 1 
ATOM   2453 N NE2 . GLN A 1 335 ? 137.798 158.622 113.637 1.00 69.40  ? 361 GLN A NE2 1 
ATOM   2454 N N   . LEU A 1 336 ? 137.275 153.266 117.925 1.00 57.02  ? 362 LEU A N   1 
ATOM   2455 C CA  . LEU A 1 336 ? 136.572 152.492 118.942 1.00 54.72  ? 362 LEU A CA  1 
ATOM   2456 C C   . LEU A 1 336 ? 137.511 152.077 120.066 1.00 59.89  ? 362 LEU A C   1 
ATOM   2457 O O   . LEU A 1 336 ? 137.117 152.072 121.236 1.00 64.98  ? 362 LEU A O   1 
ATOM   2458 C CB  . LEU A 1 336 ? 135.912 151.266 118.315 1.00 54.69  ? 362 LEU A CB  1 
ATOM   2459 C CG  . LEU A 1 336 ? 134.645 151.512 117.494 1.00 57.66  ? 362 LEU A CG  1 
ATOM   2460 C CD1 . LEU A 1 336 ? 134.125 150.209 116.911 1.00 59.93  ? 362 LEU A CD1 1 
ATOM   2461 C CD2 . LEU A 1 336 ? 133.579 152.182 118.344 1.00 59.51  ? 362 LEU A CD2 1 
ATOM   2462 N N   . GLY A 1 337 ? 138.757 151.735 119.735 1.00 51.12  ? 363 GLY A N   1 
ATOM   2463 C CA  . GLY A 1 337 ? 139.706 151.361 120.771 1.00 52.01  ? 363 GLY A CA  1 
ATOM   2464 C C   . GLY A 1 337 ? 140.024 152.503 121.717 1.00 54.75  ? 363 GLY A C   1 
ATOM   2465 O O   . GLY A 1 337 ? 140.048 152.321 122.939 1.00 64.02  ? 363 GLY A O   1 
ATOM   2466 N N   . ALA A 1 338 ? 140.264 153.696 121.171 1.00 42.03  ? 364 ALA A N   1 
ATOM   2467 C CA  . ALA A 1 338 ? 140.540 154.854 122.015 1.00 50.55  ? 364 ALA A CA  1 
ATOM   2468 C C   . ALA A 1 338 ? 139.334 155.212 122.873 1.00 57.81  ? 364 ALA A C   1 
ATOM   2469 O O   . ALA A 1 338 ? 139.478 155.517 124.067 1.00 61.17  ? 364 ALA A O   1 
ATOM   2470 C CB  . ALA A 1 338 ? 140.958 156.042 121.153 1.00 52.50  ? 364 ALA A CB  1 
ATOM   2471 N N   . ALA A 1 339 ? 138.134 155.180 122.284 1.00 52.73  ? 365 ALA A N   1 
ATOM   2472 C CA  . ALA A 1 339 ? 136.933 155.475 123.055 1.00 48.24  ? 365 ALA A CA  1 
ATOM   2473 C C   . ALA A 1 339 ? 136.736 154.458 124.171 1.00 50.93  ? 365 ALA A C   1 
ATOM   2474 O O   . ALA A 1 339 ? 136.384 154.825 125.301 1.00 58.18  ? 365 ALA A O   1 
ATOM   2475 C CB  . ALA A 1 339 ? 135.713 155.511 122.136 1.00 48.26  ? 365 ALA A CB  1 
ATOM   2476 N N   . PHE A 1 340 ? 136.973 153.177 123.879 1.00 47.99  ? 366 PHE A N   1 
ATOM   2477 C CA  . PHE A 1 340 ? 136.850 152.146 124.901 1.00 51.22  ? 366 PHE A CA  1 
ATOM   2478 C C   . PHE A 1 340 ? 137.849 152.366 126.023 1.00 50.73  ? 366 PHE A C   1 
ATOM   2479 O O   . PHE A 1 340 ? 137.497 152.259 127.202 1.00 56.40  ? 366 PHE A O   1 
ATOM   2480 C CB  . PHE A 1 340 ? 137.043 150.764 124.281 1.00 49.37  ? 366 PHE A CB  1 
ATOM   2481 C CG  . PHE A 1 340 ? 137.105 149.651 125.287 1.00 48.32  ? 366 PHE A CG  1 
ATOM   2482 C CD1 . PHE A 1 340 ? 135.946 149.124 125.827 1.00 54.34  ? 366 PHE A CD1 1 
ATOM   2483 C CD2 . PHE A 1 340 ? 138.321 149.126 125.687 1.00 45.56  ? 366 PHE A CD2 1 
ATOM   2484 C CE1 . PHE A 1 340 ? 136.000 148.101 126.750 1.00 54.01  ? 366 PHE A CE1 1 
ATOM   2485 C CE2 . PHE A 1 340 ? 138.379 148.104 126.609 1.00 51.57  ? 366 PHE A CE2 1 
ATOM   2486 C CZ  . PHE A 1 340 ? 137.219 147.591 127.140 1.00 51.66  ? 366 PHE A CZ  1 
ATOM   2487 N N   . THR A 1 341 ? 139.097 152.690 125.679 1.00 39.84  ? 367 THR A N   1 
ATOM   2488 C CA  . THR A 1 341 ? 140.105 152.917 126.709 1.00 41.52  ? 367 THR A CA  1 
ATOM   2489 C C   . THR A 1 341 ? 139.704 154.071 127.618 1.00 49.05  ? 367 THR A C   1 
ATOM   2490 O O   . THR A 1 341 ? 139.697 153.936 128.851 1.00 57.91  ? 367 THR A O   1 
ATOM   2491 C CB  . THR A 1 341 ? 141.463 153.190 126.062 1.00 43.11  ? 367 THR A CB  1 
ATOM   2492 O OG1 . THR A 1 341 ? 141.896 152.026 125.347 1.00 52.53  ? 367 THR A OG1 1 
ATOM   2493 C CG2 . THR A 1 341 ? 142.494 153.544 127.118 1.00 42.90  ? 367 THR A CG2 1 
ATOM   2494 N N   . LEU A 1 342 ? 139.325 155.205 127.023 1.00 38.57  ? 368 LEU A N   1 
ATOM   2495 C CA  . LEU A 1 342 ? 138.975 156.374 127.824 1.00 35.97  ? 368 LEU A CA  1 
ATOM   2496 C C   . LEU A 1 342 ? 137.763 156.098 128.707 1.00 41.25  ? 368 LEU A C   1 
ATOM   2497 O O   . LEU A 1 342 ? 137.786 156.372 129.915 1.00 51.89  ? 368 LEU A O   1 
ATOM   2498 C CB  . LEU A 1 342 ? 138.720 157.578 126.918 1.00 35.69  ? 368 LEU A CB  1 
ATOM   2499 C CG  . LEU A 1 342 ? 139.921 158.112 126.136 1.00 46.82  ? 368 LEU A CG  1 
ATOM   2500 C CD1 . LEU A 1 342 ? 139.520 159.314 125.301 1.00 46.63  ? 368 LEU A CD1 1 
ATOM   2501 C CD2 . LEU A 1 342 ? 141.060 158.468 127.074 1.00 45.99  ? 368 LEU A CD2 1 
ATOM   2502 N N   . LEU A 1 343 ? 136.697 155.542 128.124 1.00 31.19  ? 369 LEU A N   1 
ATOM   2503 C CA  . LEU A 1 343 ? 135.476 155.320 128.888 1.00 29.48  ? 369 LEU A CA  1 
ATOM   2504 C C   . LEU A 1 343 ? 135.682 154.282 129.983 1.00 36.39  ? 369 LEU A C   1 
ATOM   2505 O O   . LEU A 1 343 ? 135.182 154.451 131.101 1.00 45.49  ? 369 LEU A O   1 
ATOM   2506 C CB  . LEU A 1 343 ? 134.340 154.903 127.955 1.00 33.74  ? 369 LEU A CB  1 
ATOM   2507 C CG  . LEU A 1 343 ? 133.441 156.025 127.431 1.00 36.63  ? 369 LEU A CG  1 
ATOM   2508 C CD1 . LEU A 1 343 ? 134.242 157.077 126.683 1.00 35.73  ? 369 LEU A CD1 1 
ATOM   2509 C CD2 . LEU A 1 343 ? 132.345 155.458 126.544 1.00 40.35  ? 369 LEU A CD2 1 
ATOM   2510 N N   . TYR A 1 344 ? 136.413 153.204 129.690 1.00 29.86  ? 370 TYR A N   1 
ATOM   2511 C CA  . TYR A 1 344 ? 136.656 152.180 130.697 1.00 33.11  ? 370 TYR A CA  1 
ATOM   2512 C C   . TYR A 1 344 ? 137.487 152.723 131.850 1.00 42.84  ? 370 TYR A C   1 
ATOM   2513 O O   . TYR A 1 344 ? 137.201 152.427 133.016 1.00 50.94  ? 370 TYR A O   1 
ATOM   2514 C CB  . TYR A 1 344 ? 137.342 150.975 130.058 1.00 35.15  ? 370 TYR A CB  1 
ATOM   2515 C CG  . TYR A 1 344 ? 137.611 149.841 131.016 1.00 34.51  ? 370 TYR A CG  1 
ATOM   2516 C CD1 . TYR A 1 344 ? 136.636 148.896 131.293 1.00 35.74  ? 370 TYR A CD1 1 
ATOM   2517 C CD2 . TYR A 1 344 ? 138.843 149.709 131.636 1.00 39.28  ? 370 TYR A CD2 1 
ATOM   2518 C CE1 . TYR A 1 344 ? 136.878 147.857 132.165 1.00 40.60  ? 370 TYR A CE1 1 
ATOM   2519 C CE2 . TYR A 1 344 ? 139.093 148.675 132.510 1.00 41.93  ? 370 TYR A CE2 1 
ATOM   2520 C CZ  . TYR A 1 344 ? 138.108 147.752 132.771 1.00 42.96  ? 370 TYR A CZ  1 
ATOM   2521 O OH  . TYR A 1 344 ? 138.354 146.716 133.642 1.00 46.94  ? 370 TYR A OH  1 
ATOM   2522 N N   . LEU A 1 345 ? 138.515 153.527 131.556 1.00 38.98  ? 371 LEU A N   1 
ATOM   2523 C CA  . LEU A 1 345 ? 139.322 154.070 132.644 1.00 35.13  ? 371 LEU A CA  1 
ATOM   2524 C C   . LEU A 1 345 ? 138.523 155.060 133.483 1.00 42.32  ? 371 LEU A C   1 
ATOM   2525 O O   . LEU A 1 345 ? 138.632 155.067 134.717 1.00 54.02  ? 371 LEU A O   1 
ATOM   2526 C CB  . LEU A 1 345 ? 140.588 154.719 132.088 1.00 38.22  ? 371 LEU A CB  1 
ATOM   2527 C CG  . LEU A 1 345 ? 141.593 153.750 131.461 1.00 39.77  ? 371 LEU A CG  1 
ATOM   2528 C CD1 . LEU A 1 345 ? 142.862 154.473 131.047 1.00 42.00  ? 371 LEU A CD1 1 
ATOM   2529 C CD2 . LEU A 1 345 ? 141.909 152.612 132.415 1.00 37.50  ? 371 LEU A CD2 1 
ATOM   2530 N N   . LEU A 1 346 ? 137.695 155.889 132.839 1.00 34.76  ? 372 LEU A N   1 
ATOM   2531 C CA  . LEU A 1 346 ? 136.849 156.804 133.600 1.00 31.53  ? 372 LEU A CA  1 
ATOM   2532 C C   . LEU A 1 346 ? 135.858 156.045 134.476 1.00 37.49  ? 372 LEU A C   1 
ATOM   2533 O O   . LEU A 1 346 ? 135.627 156.423 135.630 1.00 43.49  ? 372 LEU A O   1 
ATOM   2534 C CB  . LEU A 1 346 ? 136.114 157.753 132.657 1.00 31.01  ? 372 LEU A CB  1 
ATOM   2535 C CG  . LEU A 1 346 ? 136.746 159.127 132.429 1.00 37.47  ? 372 LEU A CG  1 
ATOM   2536 C CD1 . LEU A 1 346 ? 138.147 159.002 131.853 1.00 39.71  ? 372 LEU A CD1 1 
ATOM   2537 C CD2 . LEU A 1 346 ? 135.865 159.965 131.520 1.00 39.72  ? 372 LEU A CD2 1 
ATOM   2538 N N   . GLU A 1 347 ? 135.262 154.975 133.945 1.00 35.88  ? 373 GLU A N   1 
ATOM   2539 C CA  . GLU A 1 347 ? 134.317 154.186 134.729 1.00 31.93  ? 373 GLU A CA  1 
ATOM   2540 C C   . GLU A 1 347 ? 135.006 153.505 135.903 1.00 34.96  ? 373 GLU A C   1 
ATOM   2541 O O   . GLU A 1 347 ? 134.443 153.429 137.002 1.00 46.43  ? 373 GLU A O   1 
ATOM   2542 C CB  . GLU A 1 347 ? 133.627 153.159 133.832 1.00 33.17  ? 373 GLU A CB  1 
ATOM   2543 C CG  . GLU A 1 347 ? 132.577 152.310 134.529 1.00 36.00  ? 373 GLU A CG  1 
ATOM   2544 C CD  . GLU A 1 347 ? 133.119 150.976 134.998 1.00 47.87  ? 373 GLU A CD  1 
ATOM   2545 O OE1 . GLU A 1 347 ? 134.336 150.741 134.853 1.00 49.33  ? 373 GLU A OE1 1 
ATOM   2546 O OE2 . GLU A 1 347 ? 132.326 150.157 135.508 1.00 51.25  ? 373 GLU A OE2 1 
ATOM   2547 N N   . GLN A 1 348 ? 136.224 153.000 135.692 1.00 30.92  ? 374 GLN A N   1 
ATOM   2548 C CA  . GLN A 1 348 ? 136.962 152.375 136.784 1.00 30.31  ? 374 GLN A CA  1 
ATOM   2549 C C   . GLN A 1 348 ? 137.354 153.388 137.850 1.00 37.91  ? 374 GLN A C   1 
ATOM   2550 O O   . GLN A 1 348 ? 137.414 153.043 139.035 1.00 42.25  ? 374 GLN A O   1 
ATOM   2551 C CB  . GLN A 1 348 ? 138.201 151.665 136.245 1.00 31.39  ? 374 GLN A CB  1 
ATOM   2552 C CG  . GLN A 1 348 ? 137.894 150.394 135.485 1.00 33.54  ? 374 GLN A CG  1 
ATOM   2553 C CD  . GLN A 1 348 ? 137.225 149.356 136.353 1.00 35.17  ? 374 GLN A CD  1 
ATOM   2554 O OE1 . GLN A 1 348 ? 137.605 149.159 137.506 1.00 34.80  ? 374 GLN A OE1 1 
ATOM   2555 N NE2 . GLN A 1 348 ? 136.217 148.686 135.808 1.00 40.79  ? 374 GLN A NE2 1 
ATOM   2556 N N   . LEU A 1 349 ? 137.640 154.629 137.454 1.00 36.44  ? 375 LEU A N   1 
ATOM   2557 C CA  . LEU A 1 349 ? 137.893 155.666 138.450 1.00 32.07  ? 375 LEU A CA  1 
ATOM   2558 C C   . LEU A 1 349 ? 136.622 156.029 139.210 1.00 42.04  ? 375 LEU A C   1 
ATOM   2559 O O   . LEU A 1 349 ? 136.661 156.252 140.425 1.00 45.98  ? 375 LEU A O   1 
ATOM   2560 C CB  . LEU A 1 349 ? 138.487 156.907 137.786 1.00 28.37  ? 375 LEU A CB  1 
ATOM   2561 C CG  . LEU A 1 349 ? 139.952 156.838 137.364 1.00 34.14  ? 375 LEU A CG  1 
ATOM   2562 C CD1 . LEU A 1 349 ? 140.382 158.157 136.752 1.00 37.11  ? 375 LEU A CD1 1 
ATOM   2563 C CD2 . LEU A 1 349 ? 140.830 156.487 138.552 1.00 41.05  ? 375 LEU A CD2 1 
ATOM   2564 N N   . PHE A 1 350 ? 135.487 156.095 138.512 1.00 41.92  ? 376 PHE A N   1 
ATOM   2565 C CA  . PHE A 1 350 ? 134.262 156.596 139.128 1.00 27.15  ? 376 PHE A CA  1 
ATOM   2566 C C   . PHE A 1 350 ? 133.599 155.569 140.038 1.00 34.92  ? 376 PHE A C   1 
ATOM   2567 O O   . PHE A 1 350 ? 133.037 155.939 141.075 1.00 47.18  ? 376 PHE A O   1 
ATOM   2568 C CB  . PHE A 1 350 ? 133.278 157.045 138.050 1.00 29.59  ? 376 PHE A CB  1 
ATOM   2569 C CG  . PHE A 1 350 ? 131.953 157.491 138.593 1.00 35.71  ? 376 PHE A CG  1 
ATOM   2570 C CD1 . PHE A 1 350 ? 131.826 158.720 139.214 1.00 39.56  ? 376 PHE A CD1 1 
ATOM   2571 C CD2 . PHE A 1 350 ? 130.835 156.684 138.482 1.00 41.51  ? 376 PHE A CD2 1 
ATOM   2572 C CE1 . PHE A 1 350 ? 130.611 159.134 139.716 1.00 40.93  ? 376 PHE A CE1 1 
ATOM   2573 C CE2 . PHE A 1 350 ? 129.617 157.095 138.983 1.00 42.74  ? 376 PHE A CE2 1 
ATOM   2574 C CZ  . PHE A 1 350 ? 129.506 158.322 139.600 1.00 41.00  ? 376 PHE A CZ  1 
ATOM   2575 N N   . LEU A 1 351 ? 133.637 154.288 139.669 1.00 41.50  ? 377 LEU A N   1 
ATOM   2576 C CA  . LEU A 1 351 ? 132.824 153.294 140.369 1.00 42.07  ? 377 LEU A CA  1 
ATOM   2577 C C   . LEU A 1 351 ? 133.106 153.182 141.865 1.00 41.56  ? 377 LEU A C   1 
ATOM   2578 O O   . LEU A 1 351 ? 132.134 153.085 142.634 1.00 49.56  ? 377 LEU A O   1 
ATOM   2579 C CB  . LEU A 1 351 ? 132.978 151.927 139.692 1.00 41.65  ? 377 LEU A CB  1 
ATOM   2580 C CG  . LEU A 1 351 ? 131.677 151.308 139.177 1.00 40.59  ? 377 LEU A CG  1 
ATOM   2581 C CD1 . LEU A 1 351 ? 131.910 149.883 138.718 1.00 41.07  ? 377 LEU A CD1 1 
ATOM   2582 C CD2 . LEU A 1 351 ? 130.597 151.355 140.242 1.00 39.15  ? 377 LEU A CD2 1 
ATOM   2583 N N   . PRO A 1 352 ? 134.354 153.175 142.348 1.00 33.26  ? 378 PRO A N   1 
ATOM   2584 C CA  . PRO A 1 352 ? 134.562 153.063 143.802 1.00 35.74  ? 378 PRO A CA  1 
ATOM   2585 C C   . PRO A 1 352 ? 133.958 154.202 144.601 1.00 44.28  ? 378 PRO A C   1 
ATOM   2586 O O   . PRO A 1 352 ? 133.710 154.030 145.800 1.00 48.36  ? 378 PRO A O   1 
ATOM   2587 C CB  . PRO A 1 352 ? 136.090 153.039 143.936 1.00 41.28  ? 378 PRO A CB  1 
ATOM   2588 C CG  . PRO A 1 352 ? 136.562 152.510 142.642 1.00 42.49  ? 378 PRO A CG  1 
ATOM   2589 C CD  . PRO A 1 352 ? 135.632 153.086 141.622 1.00 37.59  ? 378 PRO A CD  1 
ATOM   2590 N N   . TYR A 1 353 ? 133.711 155.358 143.985 1.00 41.43  ? 379 TYR A N   1 
ATOM   2591 C CA  . TYR A 1 353 ? 133.144 156.507 144.678 1.00 32.45  ? 379 TYR A CA  1 
ATOM   2592 C C   . TYR A 1 353 ? 131.706 156.789 144.259 1.00 35.03  ? 379 TYR A C   1 
ATOM   2593 O O   . TYR A 1 353 ? 131.231 157.919 144.406 1.00 43.12  ? 379 TYR A O   1 
ATOM   2594 C CB  . TYR A 1 353 ? 134.015 157.741 144.452 1.00 29.78  ? 379 TYR A CB  1 
ATOM   2595 C CG  . TYR A 1 353 ? 135.372 157.638 145.103 1.00 36.58  ? 379 TYR A CG  1 
ATOM   2596 C CD1 . TYR A 1 353 ? 135.513 157.763 146.477 1.00 42.36  ? 379 TYR A CD1 1 
ATOM   2597 C CD2 . TYR A 1 353 ? 136.511 157.419 144.345 1.00 35.02  ? 379 TYR A CD2 1 
ATOM   2598 C CE1 . TYR A 1 353 ? 136.750 157.670 147.079 1.00 39.48  ? 379 TYR A CE1 1 
ATOM   2599 C CE2 . TYR A 1 353 ? 137.752 157.325 144.938 1.00 37.35  ? 379 TYR A CE2 1 
ATOM   2600 C CZ  . TYR A 1 353 ? 137.865 157.451 146.304 1.00 39.38  ? 379 TYR A CZ  1 
ATOM   2601 O OH  . TYR A 1 353 ? 139.098 157.359 146.903 1.00 39.93  ? 379 TYR A OH  1 
ATOM   2602 N N   . SER A 1 354 ? 131.001 155.782 143.743 1.00 35.52  ? 380 SER A N   1 
ATOM   2603 C CA  . SER A 1 354 ? 129.618 155.933 143.308 1.00 41.83  ? 380 SER A CA  1 
ATOM   2604 C C   . SER A 1 354 ? 128.618 155.535 144.384 1.00 49.80  ? 380 SER A C   1 
ATOM   2605 O O   . SER A 1 354 ? 127.497 155.120 144.060 1.00 52.38  ? 380 SER A O   1 
ATOM   2606 C CB  . SER A 1 354 ? 129.378 155.118 142.038 1.00 41.95  ? 380 SER A CB  1 
ATOM   2607 O OG  . SER A 1 354 ? 129.542 153.734 142.288 1.00 46.80  ? 380 SER A OG  1 
ATOM   2608 N N   . HIS A 1 355 ? 128.989 155.653 145.659 1.00 47.81  ? 381 HIS A N   1 
ATOM   2609 C CA  . HIS A 1 355 ? 128.130 155.193 146.741 1.00 44.49  ? 381 HIS A CA  1 
ATOM   2610 C C   . HIS A 1 355 ? 127.056 156.200 147.126 1.00 41.35  ? 381 HIS A C   1 
ATOM   2611 O O   . HIS A 1 355 ? 126.182 155.864 147.933 1.00 44.67  ? 381 HIS A O   1 
ATOM   2612 C CB  . HIS A 1 355 ? 128.975 154.851 147.969 1.00 46.15  ? 381 HIS A CB  1 
ATOM   2613 C CG  . HIS A 1 355 ? 130.025 153.818 147.707 1.00 46.17  ? 381 HIS A CG  1 
ATOM   2614 N ND1 . HIS A 1 355 ? 129.758 152.636 147.051 1.00 45.31  ? 381 HIS A ND1 1 
ATOM   2615 C CD2 . HIS A 1 355 ? 131.343 153.787 148.016 1.00 44.94  ? 381 HIS A CD2 1 
ATOM   2616 C CE1 . HIS A 1 355 ? 130.866 151.923 146.965 1.00 46.26  ? 381 HIS A CE1 1 
ATOM   2617 N NE2 . HIS A 1 355 ? 131.842 152.598 147.543 1.00 47.83  ? 381 HIS A NE2 1 
ATOM   2618 N N   . PHE A 1 356 ? 127.090 157.414 146.581 1.00 37.91  ? 382 PHE A N   1 
ATOM   2619 C CA  . PHE A 1 356 ? 126.046 158.393 146.852 1.00 37.54  ? 382 PHE A CA  1 
ATOM   2620 C C   . PHE A 1 356 ? 124.843 158.240 145.935 1.00 42.52  ? 382 PHE A C   1 
ATOM   2621 O O   . PHE A 1 356 ? 123.834 158.922 146.143 1.00 50.10  ? 382 PHE A O   1 
ATOM   2622 C CB  . PHE A 1 356 ? 126.602 159.819 146.743 1.00 44.40  ? 382 PHE A CB  1 
ATOM   2623 C CG  . PHE A 1 356 ? 127.119 160.174 145.378 1.00 44.46  ? 382 PHE A CG  1 
ATOM   2624 C CD1 . PHE A 1 356 ? 128.439 159.931 145.040 1.00 45.08  ? 382 PHE A CD1 1 
ATOM   2625 C CD2 . PHE A 1 356 ? 126.292 160.767 144.440 1.00 42.52  ? 382 PHE A CD2 1 
ATOM   2626 C CE1 . PHE A 1 356 ? 128.918 160.262 143.790 1.00 45.19  ? 382 PHE A CE1 1 
ATOM   2627 C CE2 . PHE A 1 356 ? 126.768 161.098 143.189 1.00 43.94  ? 382 PHE A CE2 1 
ATOM   2628 C CZ  . PHE A 1 356 ? 128.082 160.845 142.865 1.00 43.74  ? 382 PHE A CZ  1 
ATOM   2629 N N   . LEU A 1 357 ? 124.924 157.369 144.932 1.00 41.60  ? 383 LEU A N   1 
ATOM   2630 C CA  . LEU A 1 357 ? 123.807 157.076 144.045 1.00 41.58  ? 383 LEU A CA  1 
ATOM   2631 C C   . LEU A 1 357 ? 123.042 155.828 144.459 1.00 42.70  ? 383 LEU A C   1 
ATOM   2632 O O   . LEU A 1 357 ? 121.808 155.827 144.436 1.00 46.66  ? 383 LEU A O   1 
ATOM   2633 C CB  . LEU A 1 357 ? 124.302 156.916 142.604 1.00 44.51  ? 383 LEU A CB  1 
ATOM   2634 C CG  . LEU A 1 357 ? 124.914 158.157 141.951 1.00 44.90  ? 383 LEU A CG  1 
ATOM   2635 C CD1 . LEU A 1 357 ? 125.434 157.828 140.563 1.00 43.38  ? 383 LEU A CD1 1 
ATOM   2636 C CD2 . LEU A 1 357 ? 123.899 159.285 141.890 1.00 42.13  ? 383 LEU A CD2 1 
ATOM   2637 N N   . THR A 1 358 ? 123.748 154.763 144.837 1.00 46.58  ? 384 THR A N   1 
ATOM   2638 C CA  . THR A 1 358 ? 123.123 153.540 145.334 1.00 50.37  ? 384 THR A CA  1 
ATOM   2639 C C   . THR A 1 358 ? 123.140 153.593 146.859 1.00 50.83  ? 384 THR A C   1 
ATOM   2640 O O   . THR A 1 358 ? 123.944 152.945 147.527 1.00 55.93  ? 384 THR A O   1 
ATOM   2641 C CB  . THR A 1 358 ? 123.846 152.306 144.802 1.00 49.69  ? 384 THR A CB  1 
ATOM   2642 O OG1 . THR A 1 358 ? 125.192 152.291 145.294 1.00 48.63  ? 384 THR A OG1 1 
ATOM   2643 C CG2 . THR A 1 358 ? 123.871 152.315 143.281 1.00 50.20  ? 384 THR A CG2 1 
ATOM   2644 N N   . GLN A 1 359 ? 122.226 154.391 147.413 1.00 40.58  ? 385 GLN A N   1 
ATOM   2645 C CA  . GLN A 1 359 ? 122.178 154.598 148.853 1.00 35.10  ? 385 GLN A CA  1 
ATOM   2646 C C   . GLN A 1 359 ? 121.471 153.476 149.599 1.00 43.81  ? 385 GLN A C   1 
ATOM   2647 O O   . GLN A 1 359 ? 121.543 153.436 150.831 1.00 52.79  ? 385 GLN A O   1 
ATOM   2648 C CB  . GLN A 1 359 ? 121.500 155.932 149.172 1.00 39.08  ? 385 GLN A CB  1 
ATOM   2649 C CG  . GLN A 1 359 ? 122.297 157.143 148.735 1.00 43.85  ? 385 GLN A CG  1 
ATOM   2650 C CD  . GLN A 1 359 ? 121.691 158.443 149.212 1.00 50.12  ? 385 GLN A CD  1 
ATOM   2651 O OE1 . GLN A 1 359 ? 120.663 158.886 148.702 1.00 48.94  ? 385 GLN A OE1 1 
ATOM   2652 N NE2 . GLN A 1 359 ? 122.324 159.063 150.200 1.00 51.85  ? 385 GLN A NE2 1 
ATOM   2653 N N   . GLY A 1 360 ? 120.794 152.570 148.893 1.00 42.23  ? 386 GLY A N   1 
ATOM   2654 C CA  . GLY A 1 360 ? 120.165 151.449 149.565 1.00 37.94  ? 386 GLY A CA  1 
ATOM   2655 C C   . GLY A 1 360 ? 121.163 150.491 150.180 1.00 41.08  ? 386 GLY A C   1 
ATOM   2656 O O   . GLY A 1 360 ? 120.904 149.919 151.243 1.00 52.81  ? 386 GLY A O   1 
ATOM   2657 N N   . TYR A 1 361 ? 122.306 150.300 149.530 1.00 39.89  ? 387 TYR A N   1 
ATOM   2658 C CA  . TYR A 1 361 ? 123.334 149.388 150.006 1.00 42.48  ? 387 TYR A CA  1 
ATOM   2659 C C   . TYR A 1 361 ? 124.270 150.025 151.023 1.00 47.06  ? 387 TYR A C   1 
ATOM   2660 O O   . TYR A 1 361 ? 125.154 149.338 151.544 1.00 51.33  ? 387 TYR A O   1 
ATOM   2661 C CB  . TYR A 1 361 ? 124.146 148.850 148.825 1.00 41.21  ? 387 TYR A CB  1 
ATOM   2662 C CG  . TYR A 1 361 ? 123.313 148.097 147.817 1.00 45.25  ? 387 TYR A CG  1 
ATOM   2663 C CD1 . TYR A 1 361 ? 122.972 146.769 148.024 1.00 45.82  ? 387 TYR A CD1 1 
ATOM   2664 C CD2 . TYR A 1 361 ? 122.863 148.714 146.661 1.00 40.51  ? 387 TYR A CD2 1 
ATOM   2665 C CE1 . TYR A 1 361 ? 122.209 146.077 147.109 1.00 40.47  ? 387 TYR A CE1 1 
ATOM   2666 C CE2 . TYR A 1 361 ? 122.099 148.030 145.741 1.00 40.19  ? 387 TYR A CE2 1 
ATOM   2667 C CZ  . TYR A 1 361 ? 121.775 146.713 145.970 1.00 42.19  ? 387 TYR A CZ  1 
ATOM   2668 O OH  . TYR A 1 361 ? 121.014 146.025 145.055 1.00 50.73  ? 387 TYR A OH  1 
ATOM   2669 N N   . ASN A 1 362 ? 124.100 151.311 151.317 1.00 43.35  ? 388 ASN A N   1 
ATOM   2670 C CA  . ASN A 1 362 ? 124.942 151.965 152.305 1.00 34.55  ? 388 ASN A CA  1 
ATOM   2671 C C   . ASN A 1 362 ? 124.614 151.467 153.708 1.00 42.28  ? 388 ASN A C   1 
ATOM   2672 O O   . ASN A 1 362 ? 123.475 151.113 154.022 1.00 46.59  ? 388 ASN A O   1 
ATOM   2673 C CB  . ASN A 1 362 ? 124.776 153.482 152.234 1.00 40.39  ? 388 ASN A CB  1 
ATOM   2674 C CG  . ASN A 1 362 ? 125.385 154.075 150.981 1.00 46.68  ? 388 ASN A CG  1 
ATOM   2675 O OD1 . ASN A 1 362 ? 126.235 153.458 150.341 1.00 48.22  ? 388 ASN A OD1 1 
ATOM   2676 N ND2 . ASN A 1 362 ? 124.960 155.282 150.630 1.00 48.83  ? 388 ASN A ND2 1 
ATOM   2677 N N   . ASN A 1 363 ? 125.637 151.444 154.550 1.00 49.69  ? 389 ASN A N   1 
ATOM   2678 C CA  . ASN A 1 363 ? 125.567 150.918 155.907 1.00 46.12  ? 389 ASN A CA  1 
ATOM   2679 C C   . ASN A 1 363 ? 126.574 151.696 156.745 1.00 51.45  ? 389 ASN A C   1 
ATOM   2680 O O   . ASN A 1 363 ? 126.944 152.823 156.399 1.00 59.33  ? 389 ASN A O   1 
ATOM   2681 C CB  . ASN A 1 363 ? 125.819 149.400 155.919 1.00 45.80  ? 389 ASN A CB  1 
ATOM   2682 C CG  . ASN A 1 363 ? 124.679 148.617 155.306 1.00 51.68  ? 389 ASN A CG  1 
ATOM   2683 O OD1 . ASN A 1 363 ? 124.868 147.875 154.342 1.00 54.60  ? 389 ASN A OD1 1 
ATOM   2684 N ND2 . ASN A 1 363 ? 123.485 148.777 155.862 1.00 54.05  ? 389 ASN A ND2 1 
ATOM   2685 N N   . TRP A 1 364 ? 126.981 151.119 157.877 1.00 38.09  ? 390 TRP A N   1 
ATOM   2686 C CA  . TRP A 1 364 ? 128.119 151.668 158.606 1.00 41.37  ? 390 TRP A CA  1 
ATOM   2687 C C   . TRP A 1 364 ? 129.312 151.864 157.680 1.00 50.66  ? 390 TRP A C   1 
ATOM   2688 O O   . TRP A 1 364 ? 130.001 152.888 157.750 1.00 53.99  ? 390 TRP A O   1 
ATOM   2689 C CB  . TRP A 1 364 ? 128.487 150.751 159.771 1.00 45.32  ? 390 TRP A CB  1 
ATOM   2690 C CG  . TRP A 1 364 ? 127.447 150.699 160.840 1.00 47.75  ? 390 TRP A CG  1 
ATOM   2691 C CD1 . TRP A 1 364 ? 126.268 151.381 160.869 1.00 45.22  ? 390 TRP A CD1 1 
ATOM   2692 C CD2 . TRP A 1 364 ? 127.493 149.926 162.043 1.00 45.29  ? 390 TRP A CD2 1 
ATOM   2693 N NE1 . TRP A 1 364 ? 125.575 151.080 162.014 1.00 42.94  ? 390 TRP A NE1 1 
ATOM   2694 C CE2 . TRP A 1 364 ? 126.307 150.188 162.753 1.00 42.87  ? 390 TRP A CE2 1 
ATOM   2695 C CE3 . TRP A 1 364 ? 128.422 149.037 162.589 1.00 46.54  ? 390 TRP A CE3 1 
ATOM   2696 C CZ2 . TRP A 1 364 ? 126.025 149.594 163.978 1.00 47.17  ? 390 TRP A CZ2 1 
ATOM   2697 C CZ3 . TRP A 1 364 ? 128.142 148.450 163.804 1.00 44.18  ? 390 TRP A CZ3 1 
ATOM   2698 C CH2 . TRP A 1 364 ? 126.953 148.729 164.485 1.00 46.95  ? 390 TRP A CH2 1 
ATOM   2699 N N   . THR A 1 365 ? 129.572 150.893 156.808 1.00 51.43  ? 391 THR A N   1 
ATOM   2700 C CA  . THR A 1 365 ? 130.503 151.071 155.708 1.00 45.75  ? 391 THR A CA  1 
ATOM   2701 C C   . THR A 1 365 ? 129.725 151.474 154.456 1.00 47.76  ? 391 THR A C   1 
ATOM   2702 O O   . THR A 1 365 ? 128.504 151.635 154.481 1.00 56.23  ? 391 THR A O   1 
ATOM   2703 C CB  . THR A 1 365 ? 131.314 149.798 155.475 1.00 51.12  ? 391 THR A CB  1 
ATOM   2704 O OG1 . THR A 1 365 ? 132.329 150.051 154.496 1.00 53.19  ? 391 THR A OG1 1 
ATOM   2705 C CG2 . THR A 1 365 ? 130.412 148.679 154.981 1.00 52.05  ? 391 THR A CG2 1 
ATOM   2706 N N   . ASN A 1 366 ? 130.426 151.631 153.340 1.00 50.48  ? 392 ASN A N   1 
ATOM   2707 C CA  . ASN A 1 366 ? 129.820 152.125 152.110 1.00 51.04  ? 392 ASN A CA  1 
ATOM   2708 C C   . ASN A 1 366 ? 129.720 151.001 151.088 1.00 55.38  ? 392 ASN A C   1 
ATOM   2709 O O   . ASN A 1 366 ? 130.732 150.391 150.729 1.00 60.42  ? 392 ASN A O   1 
ATOM   2710 C CB  . ASN A 1 366 ? 130.621 153.295 151.540 1.00 51.89  ? 392 ASN A CB  1 
ATOM   2711 C CG  . ASN A 1 366 ? 130.364 154.591 152.277 1.00 56.29  ? 392 ASN A CG  1 
ATOM   2712 O OD1 . ASN A 1 366 ? 129.245 154.861 152.709 1.00 54.58  ? 392 ASN A OD1 1 
ATOM   2713 N ND2 . ASN A 1 366 ? 131.404 155.402 152.426 1.00 59.27  ? 392 ASN A ND2 1 
ATOM   2714 N N   . GLY A 1 367 ? 128.501 150.731 150.631 1.00 52.87  ? 393 GLY A N   1 
ATOM   2715 C CA  . GLY A 1 367 ? 128.284 149.861 149.491 1.00 49.49  ? 393 GLY A CA  1 
ATOM   2716 C C   . GLY A 1 367 ? 128.536 148.395 149.794 1.00 49.27  ? 393 GLY A C   1 
ATOM   2717 O O   . GLY A 1 367 ? 129.015 148.009 150.858 1.00 49.77  ? 393 GLY A O   1 
ATOM   2718 N N   . LEU A 1 368 ? 128.197 147.565 148.813 1.00 46.99  ? 394 LEU A N   1 
ATOM   2719 C CA  . LEU A 1 368 ? 128.523 146.150 148.883 1.00 44.08  ? 394 LEU A CA  1 
ATOM   2720 C C   . LEU A 1 368 ? 130.026 145.950 148.748 1.00 47.30  ? 394 LEU A C   1 
ATOM   2721 O O   . LEU A 1 368 ? 130.720 146.709 148.067 1.00 56.47  ? 394 LEU A O   1 
ATOM   2722 C CB  . LEU A 1 368 ? 127.794 145.373 147.787 1.00 47.32  ? 394 LEU A CB  1 
ATOM   2723 C CG  . LEU A 1 368 ? 126.275 145.260 147.900 1.00 46.76  ? 394 LEU A CG  1 
ATOM   2724 C CD1 . LEU A 1 368 ? 125.707 144.534 146.694 1.00 46.34  ? 394 LEU A CD1 1 
ATOM   2725 C CD2 . LEU A 1 368 ? 125.885 144.551 149.187 1.00 49.26  ? 394 LEU A CD2 1 
ATOM   2726 N N   . TYR A 1 369 ? 130.529 144.912 149.406 1.00 34.48  ? 395 TYR A N   1 
ATOM   2727 C CA  . TYR A 1 369 ? 131.952 144.619 149.372 1.00 41.01  ? 395 TYR A CA  1 
ATOM   2728 C C   . TYR A 1 369 ? 132.329 143.968 148.048 1.00 55.42  ? 395 TYR A C   1 
ATOM   2729 O O   . TYR A 1 369 ? 131.587 143.139 147.513 1.00 56.45  ? 395 TYR A O   1 
ATOM   2730 C CB  . TYR A 1 369 ? 132.331 143.703 150.534 1.00 34.93  ? 395 TYR A CB  1 
ATOM   2731 C CG  . TYR A 1 369 ? 133.817 143.565 150.748 1.00 41.73  ? 395 TYR A CG  1 
ATOM   2732 C CD1 . TYR A 1 369 ? 134.523 144.521 151.461 1.00 47.24  ? 395 TYR A CD1 1 
ATOM   2733 C CD2 . TYR A 1 369 ? 134.513 142.479 150.245 1.00 43.89  ? 395 TYR A CD2 1 
ATOM   2734 C CE1 . TYR A 1 369 ? 135.881 144.401 151.661 1.00 48.53  ? 395 TYR A CE1 1 
ATOM   2735 C CE2 . TYR A 1 369 ? 135.870 142.350 150.440 1.00 45.46  ? 395 TYR A CE2 1 
ATOM   2736 C CZ  . TYR A 1 369 ? 136.549 143.313 151.149 1.00 49.18  ? 395 TYR A CZ  1 
ATOM   2737 O OH  . TYR A 1 369 ? 137.904 143.188 151.347 1.00 53.34  ? 395 TYR A OH  1 
ATOM   2738 N N   . GLY A 1 370 ? 133.490 144.347 147.518 1.00 51.48  ? 396 GLY A N   1 
ATOM   2739 C CA  . GLY A 1 370 ? 133.995 143.705 146.322 1.00 43.78  ? 396 GLY A CA  1 
ATOM   2740 C C   . GLY A 1 370 ? 134.576 144.609 145.253 1.00 51.17  ? 396 GLY A C   1 
ATOM   2741 O O   . GLY A 1 370 ? 135.494 144.196 144.538 1.00 60.54  ? 396 GLY A O   1 
ATOM   2742 N N   . TYR A 1 371 ? 134.067 145.837 145.119 1.00 44.19  ? 397 TYR A N   1 
ATOM   2743 C CA  . TYR A 1 371 ? 134.501 146.709 144.033 1.00 42.71  ? 397 TYR A CA  1 
ATOM   2744 C C   . TYR A 1 371 ? 134.961 148.080 144.518 1.00 46.37  ? 397 TYR A C   1 
ATOM   2745 O O   . TYR A 1 371 ? 134.992 149.029 143.728 1.00 54.16  ? 397 TYR A O   1 
ATOM   2746 C CB  . TYR A 1 371 ? 133.392 146.865 142.988 1.00 46.79  ? 397 TYR A CB  1 
ATOM   2747 C CG  . TYR A 1 371 ? 132.168 147.613 143.465 1.00 45.02  ? 397 TYR A CG  1 
ATOM   2748 C CD1 . TYR A 1 371 ? 131.191 146.980 144.217 1.00 41.20  ? 397 TYR A CD1 1 
ATOM   2749 C CD2 . TYR A 1 371 ? 131.979 148.950 143.143 1.00 48.40  ? 397 TYR A CD2 1 
ATOM   2750 C CE1 . TYR A 1 371 ? 130.072 147.657 144.646 1.00 44.70  ? 397 TYR A CE1 1 
ATOM   2751 C CE2 . TYR A 1 371 ? 130.863 149.635 143.569 1.00 49.61  ? 397 TYR A CE2 1 
ATOM   2752 C CZ  . TYR A 1 371 ? 129.912 148.984 144.319 1.00 49.95  ? 397 TYR A CZ  1 
ATOM   2753 O OH  . TYR A 1 371 ? 128.796 149.664 144.746 1.00 51.16  ? 397 TYR A OH  1 
ATOM   2754 N N   . SER A 1 372 ? 135.332 148.209 145.790 1.00 44.52  ? 398 SER A N   1 
ATOM   2755 C CA  . SER A 1 372 ? 135.814 149.474 146.322 1.00 43.63  ? 398 SER A CA  1 
ATOM   2756 C C   . SER A 1 372 ? 137.304 149.474 146.624 1.00 45.38  ? 398 SER A C   1 
ATOM   2757 O O   . SER A 1 372 ? 137.845 150.528 146.976 1.00 54.55  ? 398 SER A O   1 
ATOM   2758 C CB  . SER A 1 372 ? 135.041 149.846 147.596 1.00 48.92  ? 398 SER A CB  1 
ATOM   2759 O OG  . SER A 1 372 ? 133.660 150.006 147.326 1.00 53.72  ? 398 SER A OG  1 
ATOM   2760 N N   . TRP A 1 373 ? 137.972 148.326 146.511 1.00 46.20  ? 399 TRP A N   1 
ATOM   2761 C CA  . TRP A 1 373 ? 139.407 148.182 146.749 1.00 47.92  ? 399 TRP A CA  1 
ATOM   2762 C C   . TRP A 1 373 ? 139.796 148.518 148.185 1.00 49.53  ? 399 TRP A C   1 
ATOM   2763 O O   . TRP A 1 373 ? 140.950 148.865 148.454 1.00 53.68  ? 399 TRP A O   1 
ATOM   2764 C CB  . TRP A 1 373 ? 140.229 149.024 145.764 1.00 45.31  ? 399 TRP A CB  1 
ATOM   2765 C CG  . TRP A 1 373 ? 139.795 148.874 144.334 1.00 48.01  ? 399 TRP A CG  1 
ATOM   2766 C CD1 . TRP A 1 373 ? 139.217 149.828 143.551 1.00 53.33  ? 399 TRP A CD1 1 
ATOM   2767 C CD2 . TRP A 1 373 ? 139.893 147.698 143.524 1.00 45.40  ? 399 TRP A CD2 1 
ATOM   2768 N NE1 . TRP A 1 373 ? 138.955 149.324 142.303 1.00 49.83  ? 399 TRP A NE1 1 
ATOM   2769 C CE2 . TRP A 1 373 ? 139.359 148.016 142.261 1.00 43.95  ? 399 TRP A CE2 1 
ATOM   2770 C CE3 . TRP A 1 373 ? 140.381 146.408 143.742 1.00 47.86  ? 399 TRP A CE3 1 
ATOM   2771 C CZ2 . TRP A 1 373 ? 139.300 147.093 141.223 1.00 45.79  ? 399 TRP A CZ2 1 
ATOM   2772 C CZ3 . TRP A 1 373 ? 140.321 145.495 142.712 1.00 50.16  ? 399 TRP A CZ3 1 
ATOM   2773 C CH2 . TRP A 1 373 ? 139.785 145.841 141.468 1.00 48.50  ? 399 TRP A CH2 1 
ATOM   2774 N N   . ASP A 1 374 ? 138.850 148.421 149.122 1.00 50.43  ? 400 ASP A N   1 
ATOM   2775 C CA  . ASP A 1 374 ? 139.128 148.662 150.538 1.00 48.47  ? 400 ASP A CA  1 
ATOM   2776 C C   . ASP A 1 374 ? 139.416 147.320 151.204 1.00 51.42  ? 400 ASP A C   1 
ATOM   2777 O O   . ASP A 1 374 ? 138.580 146.728 151.889 1.00 55.41  ? 400 ASP A O   1 
ATOM   2778 C CB  . ASP A 1 374 ? 137.965 149.390 151.198 1.00 52.19  ? 400 ASP A CB  1 
ATOM   2779 C CG  . ASP A 1 374 ? 136.625 148.766 150.869 1.00 55.19  ? 400 ASP A CG  1 
ATOM   2780 O OD1 . ASP A 1 374 ? 136.592 147.821 150.053 1.00 51.06  ? 400 ASP A OD1 1 
ATOM   2781 O OD2 . ASP A 1 374 ? 135.604 149.221 151.425 1.00 56.50  ? 400 ASP A OD2 1 
ATOM   2782 N N   . MET A 1 375 ? 140.637 146.840 150.994 1.00 55.86  ? 401 MET A N   1 
ATOM   2783 C CA  . MET A 1 375 ? 141.046 145.523 151.460 1.00 54.47  ? 401 MET A CA  1 
ATOM   2784 C C   . MET A 1 375 ? 141.621 145.615 152.866 1.00 56.74  ? 401 MET A C   1 
ATOM   2785 O O   . MET A 1 375 ? 142.525 146.418 153.122 1.00 61.30  ? 401 MET A O   1 
ATOM   2786 C CB  . MET A 1 375 ? 142.081 144.924 150.507 1.00 57.61  ? 401 MET A CB  1 
ATOM   2787 C CG  . MET A 1 375 ? 141.746 145.111 149.038 1.00 61.13  ? 401 MET A CG  1 
ATOM   2788 S SD  . MET A 1 375 ? 143.103 144.634 147.952 1.00 76.32  ? 401 MET A SD  1 
ATOM   2789 C CE  . MET A 1 375 ? 142.426 145.076 146.355 1.00 59.71  ? 401 MET A CE  1 
ATOM   2790 N N   . MET A 1 376 ? 141.090 144.793 153.773 1.00 54.40  ? 402 MET A N   1 
ATOM   2791 C CA  . MET A 1 376 ? 141.625 144.643 155.127 1.00 53.91  ? 402 MET A CA  1 
ATOM   2792 C C   . MET A 1 376 ? 141.598 145.968 155.889 1.00 58.18  ? 402 MET A C   1 
ATOM   2793 O O   . MET A 1 376 ? 142.558 146.340 156.565 1.00 62.51  ? 402 MET A O   1 
ATOM   2794 C CB  . MET A 1 376 ? 143.041 144.065 155.094 1.00 57.34  ? 402 MET A CB  1 
ATOM   2795 C CG  . MET A 1 376 ? 143.194 142.801 154.266 1.00 59.57  ? 402 MET A CG  1 
ATOM   2796 S SD  . MET A 1 376 ? 142.376 141.375 154.997 1.00 74.75  ? 402 MET A SD  1 
ATOM   2797 C CE  . MET A 1 376 ? 142.894 140.081 153.875 1.00 60.68  ? 402 MET A CE  1 
ATOM   2798 N N   . VAL A 1 377 ? 140.478 146.681 155.784 1.00 50.24  ? 403 VAL A N   1 
ATOM   2799 C CA  . VAL A 1 377 ? 140.335 147.971 156.435 1.00 46.87  ? 403 VAL A CA  1 
ATOM   2800 C C   . VAL A 1 377 ? 139.369 147.930 157.615 1.00 49.38  ? 403 VAL A C   1 
ATOM   2801 O O   . VAL A 1 377 ? 139.536 148.708 158.562 1.00 53.57  ? 403 VAL A O   1 
ATOM   2802 C CB  . VAL A 1 377 ? 139.902 149.045 155.415 1.00 47.79  ? 403 VAL A CB  1 
ATOM   2803 C CG1 . VAL A 1 377 ? 139.988 150.435 156.022 1.00 50.37  ? 403 VAL A CG1 1 
ATOM   2804 C CG2 . VAL A 1 377 ? 140.752 148.959 154.161 1.00 52.17  ? 403 VAL A CG2 1 
ATOM   2805 N N   . HIS A 1 378 ? 138.382 147.037 157.603 1.00 47.27  ? 404 HIS A N   1 
ATOM   2806 C CA  . HIS A 1 378 ? 137.386 146.964 158.663 1.00 42.95  ? 404 HIS A CA  1 
ATOM   2807 C C   . HIS A 1 378 ? 137.275 145.531 159.161 1.00 51.94  ? 404 HIS A C   1 
ATOM   2808 O O   . HIS A 1 378 ? 137.224 144.593 158.359 1.00 57.95  ? 404 HIS A O   1 
ATOM   2809 C CB  . HIS A 1 378 ? 136.025 147.464 158.170 1.00 44.62  ? 404 HIS A CB  1 
ATOM   2810 C CG  . HIS A 1 378 ? 136.052 148.866 157.648 1.00 52.19  ? 404 HIS A CG  1 
ATOM   2811 N ND1 . HIS A 1 378 ? 135.760 149.959 158.434 1.00 54.37  ? 404 HIS A ND1 1 
ATOM   2812 C CD2 . HIS A 1 378 ? 136.339 149.353 156.418 1.00 52.82  ? 404 HIS A CD2 1 
ATOM   2813 C CE1 . HIS A 1 378 ? 135.864 151.059 157.710 1.00 49.25  ? 404 HIS A CE1 1 
ATOM   2814 N NE2 . HIS A 1 378 ? 136.214 150.719 156.483 1.00 52.72  ? 404 HIS A NE2 1 
ATOM   2815 N N   . SER A 1 379 ? 137.237 145.368 160.480 1.00 50.63  ? 405 SER A N   1 
ATOM   2816 C CA  . SER A 1 379 ? 137.092 144.070 161.121 1.00 44.25  ? 405 SER A CA  1 
ATOM   2817 C C   . SER A 1 379 ? 135.841 144.075 161.985 1.00 51.96  ? 405 SER A C   1 
ATOM   2818 O O   . SER A 1 379 ? 135.557 145.059 162.675 1.00 57.26  ? 405 SER A O   1 
ATOM   2819 C CB  . SER A 1 379 ? 138.315 143.733 161.977 1.00 48.76  ? 405 SER A CB  1 
ATOM   2820 O OG  . SER A 1 379 ? 139.505 143.784 161.212 1.00 49.40  ? 405 SER A OG  1 
ATOM   2821 N N   . ARG A 1 380 ? 135.095 142.975 161.947 1.00 44.49  ? 406 ARG A N   1 
ATOM   2822 C CA  . ARG A 1 380 ? 133.833 142.862 162.661 1.00 40.41  ? 406 ARG A CA  1 
ATOM   2823 C C   . ARG A 1 380 ? 133.863 141.665 163.600 1.00 45.46  ? 406 ARG A C   1 
ATOM   2824 O O   . ARG A 1 380 ? 134.402 140.608 163.260 1.00 51.25  ? 406 ARG A O   1 
ATOM   2825 C CB  . ARG A 1 380 ? 132.662 142.731 161.686 1.00 41.35  ? 406 ARG A CB  1 
ATOM   2826 C CG  . ARG A 1 380 ? 132.702 143.734 160.551 1.00 44.19  ? 406 ARG A CG  1 
ATOM   2827 C CD  . ARG A 1 380 ? 131.312 144.080 160.061 1.00 46.72  ? 406 ARG A CD  1 
ATOM   2828 N NE  . ARG A 1 380 ? 131.349 145.069 158.992 1.00 52.52  ? 406 ARG A NE  1 
ATOM   2829 C CZ  . ARG A 1 380 ? 130.306 145.787 158.600 1.00 55.65  ? 406 ARG A CZ  1 
ATOM   2830 N NH1 . ARG A 1 380 ? 129.125 145.664 159.182 1.00 56.23  ? 406 ARG A NH1 1 
ATOM   2831 N NH2 . ARG A 1 380 ? 130.453 146.654 157.603 1.00 51.75  ? 406 ARG A NH2 1 
ATOM   2832 N N   . SER A 1 381 ? 133.283 141.843 164.785 1.00 41.36  ? 407 SER A N   1 
ATOM   2833 C CA  . SER A 1 381 ? 133.131 140.776 165.769 1.00 41.96  ? 407 SER A CA  1 
ATOM   2834 C C   . SER A 1 381 ? 131.689 140.787 166.255 1.00 47.82  ? 407 SER A C   1 
ATOM   2835 O O   . SER A 1 381 ? 131.283 141.703 166.978 1.00 51.02  ? 407 SER A O   1 
ATOM   2836 C CB  . SER A 1 381 ? 134.103 140.956 166.934 1.00 45.56  ? 407 SER A CB  1 
ATOM   2837 O OG  . SER A 1 381 ? 133.927 139.944 167.909 1.00 52.86  ? 407 SER A OG  1 
ATOM   2838 N N   . HIS A 1 382 ? 130.917 139.780 165.860 1.00 42.07  ? 408 HIS A N   1 
ATOM   2839 C CA  . HIS A 1 382 ? 129.509 139.702 166.221 1.00 37.95  ? 408 HIS A CA  1 
ATOM   2840 C C   . HIS A 1 382 ? 129.343 139.016 167.570 1.00 39.72  ? 408 HIS A C   1 
ATOM   2841 O O   . HIS A 1 382 ? 129.987 138.002 167.850 1.00 45.31  ? 408 HIS A O   1 
ATOM   2842 C CB  . HIS A 1 382 ? 128.719 138.949 165.151 1.00 40.64  ? 408 HIS A CB  1 
ATOM   2843 C CG  . HIS A 1 382 ? 128.867 139.525 163.778 1.00 40.50  ? 408 HIS A CG  1 
ATOM   2844 N ND1 . HIS A 1 382 ? 129.831 139.096 162.892 1.00 42.10  ? 408 HIS A ND1 1 
ATOM   2845 C CD2 . HIS A 1 382 ? 128.178 140.500 163.141 1.00 46.69  ? 408 HIS A CD2 1 
ATOM   2846 C CE1 . HIS A 1 382 ? 129.727 139.779 161.767 1.00 45.86  ? 408 HIS A CE1 1 
ATOM   2847 N NE2 . HIS A 1 382 ? 128.732 140.638 161.891 1.00 49.32  ? 408 HIS A NE2 1 
ATOM   2848 N N   . GLN A 1 383 ? 128.468 139.576 168.404 1.00 32.45  ? 409 GLN A N   1 
ATOM   2849 C CA  . GLN A 1 383 ? 128.258 139.091 169.762 1.00 33.62  ? 409 GLN A CA  1 
ATOM   2850 C C   . GLN A 1 383 ? 127.008 138.232 169.900 1.00 45.87  ? 409 GLN A C   1 
ATOM   2851 O O   . GLN A 1 383 ? 127.072 137.135 170.463 1.00 54.01  ? 409 GLN A O   1 
ATOM   2852 C CB  . GLN A 1 383 ? 128.184 140.276 170.731 1.00 35.04  ? 409 GLN A CB  1 
ATOM   2853 C CG  . GLN A 1 383 ? 127.847 139.895 172.162 1.00 35.45  ? 409 GLN A CG  1 
ATOM   2854 C CD  . GLN A 1 383 ? 128.970 139.153 172.853 1.00 42.50  ? 409 GLN A CD  1 
ATOM   2855 O OE1 . GLN A 1 383 ? 130.114 139.173 172.401 1.00 45.84  ? 409 GLN A OE1 1 
ATOM   2856 N NE2 . GLN A 1 383 ? 128.649 138.490 173.957 1.00 43.19  ? 409 GLN A NE2 1 
ATOM   2857 N N   . HIS A 1 384 ? 125.868 138.705 169.401 1.00 37.61  ? 410 HIS A N   1 
ATOM   2858 C CA  . HIS A 1 384 ? 124.616 137.984 169.568 1.00 30.71  ? 410 HIS A CA  1 
ATOM   2859 C C   . HIS A 1 384 ? 123.667 138.339 168.434 1.00 35.31  ? 410 HIS A C   1 
ATOM   2860 O O   . HIS A 1 384 ? 123.601 139.497 168.012 1.00 48.15  ? 410 HIS A O   1 
ATOM   2861 C CB  . HIS A 1 384 ? 123.974 138.311 170.920 1.00 34.72  ? 410 HIS A CB  1 
ATOM   2862 C CG  . HIS A 1 384 ? 122.860 137.389 171.301 1.00 38.32  ? 410 HIS A CG  1 
ATOM   2863 N ND1 . HIS A 1 384 ? 123.033 136.029 171.433 1.00 43.04  ? 410 HIS A ND1 1 
ATOM   2864 C CD2 . HIS A 1 384 ? 121.560 137.633 171.589 1.00 37.31  ? 410 HIS A CD2 1 
ATOM   2865 C CE1 . HIS A 1 384 ? 121.886 135.473 171.780 1.00 43.42  ? 410 HIS A CE1 1 
ATOM   2866 N NE2 . HIS A 1 384 ? 120.976 136.425 171.881 1.00 44.82  ? 410 HIS A NE2 1 
ATOM   2867 N N   . VAL A 1 385 ? 122.936 137.338 167.945 1.00 30.87  ? 411 VAL A N   1 
ATOM   2868 C CA  . VAL A 1 385 ? 121.920 137.521 166.914 1.00 29.55  ? 411 VAL A CA  1 
ATOM   2869 C C   . VAL A 1 385 ? 120.648 136.826 167.377 1.00 31.43  ? 411 VAL A C   1 
ATOM   2870 O O   . VAL A 1 385 ? 120.650 135.609 167.595 1.00 40.52  ? 411 VAL A O   1 
ATOM   2871 C CB  . VAL A 1 385 ? 122.368 136.967 165.552 1.00 33.95  ? 411 VAL A CB  1 
ATOM   2872 C CG1 . VAL A 1 385 ? 121.282 137.183 164.513 1.00 40.35  ? 411 VAL A CG1 1 
ATOM   2873 C CG2 . VAL A 1 385 ? 123.669 137.615 165.111 1.00 37.45  ? 411 VAL A CG2 1 
ATOM   2874 N N   . LYS A 1 386 ? 119.569 137.589 167.529 1.00 27.39  ? 412 LYS A N   1 
ATOM   2875 C CA  . LYS A 1 386 ? 118.278 137.050 167.937 1.00 31.72  ? 412 LYS A CA  1 
ATOM   2876 C C   . LYS A 1 386 ? 117.243 137.324 166.856 1.00 41.89  ? 412 LYS A C   1 
ATOM   2877 O O   . LYS A 1 386 ? 117.076 138.470 166.423 1.00 48.57  ? 412 LYS A O   1 
ATOM   2878 C CB  . LYS A 1 386 ? 117.818 137.643 169.271 1.00 32.07  ? 412 LYS A CB  1 
ATOM   2879 C CG  . LYS A 1 386 ? 116.575 136.972 169.832 1.00 32.76  ? 412 LYS A CG  1 
ATOM   2880 C CD  . LYS A 1 386 ? 116.227 137.475 171.222 1.00 34.23  ? 412 LYS A CD  1 
ATOM   2881 C CE  . LYS A 1 386 ? 115.028 138.399 171.194 1.00 36.22  ? 412 LYS A CE  1 
ATOM   2882 N NZ  . LYS A 1 386 ? 114.612 138.801 172.565 1.00 41.91  ? 412 LYS A NZ  1 
ATOM   2883 N N   . ILE A 1 387 ? 116.550 136.272 166.426 1.00 39.90  ? 413 ILE A N   1 
ATOM   2884 C CA  . ILE A 1 387 ? 115.500 136.364 165.419 1.00 29.40  ? 413 ILE A CA  1 
ATOM   2885 C C   . ILE A 1 387 ? 114.195 135.937 166.071 1.00 36.76  ? 413 ILE A C   1 
ATOM   2886 O O   . ILE A 1 387 ? 114.048 134.776 166.474 1.00 47.60  ? 413 ILE A O   1 
ATOM   2887 C CB  . ILE A 1 387 ? 115.807 135.495 164.192 1.00 32.83  ? 413 ILE A CB  1 
ATOM   2888 C CG1 . ILE A 1 387 ? 117.166 135.865 163.604 1.00 33.65  ? 413 ILE A CG1 1 
ATOM   2889 C CG2 . ILE A 1 387 ? 114.717 135.647 163.147 1.00 36.95  ? 413 ILE A CG2 1 
ATOM   2890 C CD1 . ILE A 1 387 ? 117.561 135.020 162.422 1.00 37.97  ? 413 ILE A CD1 1 
ATOM   2891 N N   . THR A 1 388 ? 113.253 136.869 166.179 1.00 37.15  ? 414 THR A N   1 
ATOM   2892 C CA  . THR A 1 388 ? 111.965 136.612 166.804 1.00 30.43  ? 414 THR A CA  1 
ATOM   2893 C C   . THR A 1 388 ? 110.876 136.608 165.742 1.00 39.33  ? 414 THR A C   1 
ATOM   2894 O O   . THR A 1 388 ? 110.919 137.399 164.796 1.00 50.85  ? 414 THR A O   1 
ATOM   2895 C CB  . THR A 1 388 ? 111.654 137.668 167.868 1.00 33.13  ? 414 THR A CB  1 
ATOM   2896 O OG1 . THR A 1 388 ? 112.777 137.805 168.747 1.00 50.37  ? 414 THR A OG1 1 
ATOM   2897 C CG2 . THR A 1 388 ? 110.440 137.268 168.682 1.00 38.49  ? 414 THR A CG2 1 
ATOM   2898 N N   . TYR A 1 389 ? 109.903 135.713 165.891 1.00 40.47  ? 415 TYR A N   1 
ATOM   2899 C CA  . TYR A 1 389 ? 108.775 135.650 164.977 1.00 35.89  ? 415 TYR A CA  1 
ATOM   2900 C C   . TYR A 1 389 ? 107.475 135.654 165.766 1.00 39.89  ? 415 TYR A C   1 
ATOM   2901 O O   . TYR A 1 389 ? 107.372 135.027 166.826 1.00 53.98  ? 415 TYR A O   1 
ATOM   2902 C CB  . TYR A 1 389 ? 108.844 134.409 164.067 1.00 37.84  ? 415 TYR A CB  1 
ATOM   2903 C CG  . TYR A 1 389 ? 108.308 133.131 164.672 1.00 37.51  ? 415 TYR A CG  1 
ATOM   2904 C CD1 . TYR A 1 389 ? 109.132 132.285 165.396 1.00 39.25  ? 415 TYR A CD1 1 
ATOM   2905 C CD2 . TYR A 1 389 ? 106.982 132.760 164.499 1.00 46.92  ? 415 TYR A CD2 1 
ATOM   2906 C CE1 . TYR A 1 389 ? 108.648 131.115 165.942 1.00 43.35  ? 415 TYR A CE1 1 
ATOM   2907 C CE2 . TYR A 1 389 ? 106.490 131.595 165.045 1.00 42.97  ? 415 TYR A CE2 1 
ATOM   2908 C CZ  . TYR A 1 389 ? 107.327 130.777 165.766 1.00 42.82  ? 415 TYR A CZ  1 
ATOM   2909 O OH  . TYR A 1 389 ? 106.843 129.611 166.311 1.00 50.86  ? 415 TYR A OH  1 
ATOM   2910 N N   . ARG A 1 390 ? 106.492 136.380 165.246 1.00 40.21  ? 416 ARG A N   1 
ATOM   2911 C CA  . ARG A 1 390 ? 105.142 136.395 165.789 1.00 41.40  ? 416 ARG A CA  1 
ATOM   2912 C C   . ARG A 1 390 ? 104.184 135.849 164.744 1.00 52.59  ? 416 ARG A C   1 
ATOM   2913 O O   . ARG A 1 390 ? 104.151 136.338 163.608 1.00 59.33  ? 416 ARG A O   1 
ATOM   2914 C CB  . ARG A 1 390 ? 104.718 137.804 166.209 1.00 49.15  ? 416 ARG A CB  1 
ATOM   2915 C CG  . ARG A 1 390 ? 103.226 137.932 166.472 1.00 53.17  ? 416 ARG A CG  1 
ATOM   2916 C CD  . ARG A 1 390 ? 102.846 139.310 166.990 1.00 53.09  ? 416 ARG A CD  1 
ATOM   2917 N NE  . ARG A 1 390 ? 103.289 139.526 168.361 1.00 51.70  ? 416 ARG A NE  1 
ATOM   2918 C CZ  . ARG A 1 390 ? 104.355 140.236 168.701 1.00 55.33  ? 416 ARG A CZ  1 
ATOM   2919 N NH1 . ARG A 1 390 ? 105.109 140.828 167.790 1.00 55.96  ? 416 ARG A NH1 1 
ATOM   2920 N NH2 . ARG A 1 390 ? 104.671 140.359 169.987 1.00 54.63  ? 416 ARG A NH2 1 
ATOM   2921 N N   . ASP A 1 391 ? 103.421 134.829 165.126 1.00 62.62  ? 417 ASP A N   1 
ATOM   2922 C CA  . ASP A 1 391 ? 102.405 134.275 164.246 1.00 60.47  ? 417 ASP A CA  1 
ATOM   2923 C C   . ASP A 1 391 ? 101.283 135.285 164.040 1.00 62.93  ? 417 ASP A C   1 
ATOM   2924 O O   . ASP A 1 391 ? 100.908 136.016 164.960 1.00 68.74  ? 417 ASP A O   1 
ATOM   2925 C CB  . ASP A 1 391 ? 101.848 132.979 164.832 1.00 61.49  ? 417 ASP A CB  1 
ATOM   2926 C CG  . ASP A 1 391 ? 101.537 131.946 163.772 1.00 70.86  ? 417 ASP A CG  1 
ATOM   2927 O OD1 . ASP A 1 391 ? 101.806 132.217 162.583 1.00 74.58  ? 417 ASP A OD1 1 
ATOM   2928 O OD2 . ASP A 1 391 ? 101.028 130.861 164.125 1.00 69.40  ? 417 ASP A OD2 1 
ATOM   2929 N N   . GLY A 1 392 ? 100.746 135.323 162.826 1.00 58.23  ? 418 GLY A N   1 
ATOM   2930 C CA  . GLY A 1 392 ? 99.696  136.262 162.502 1.00 57.73  ? 418 GLY A CA  1 
ATOM   2931 C C   . GLY A 1 392 ? 98.287  135.760 162.697 1.00 60.64  ? 418 GLY A C   1 
ATOM   2932 O O   . GLY A 1 392 ? 97.335  136.498 162.428 1.00 67.90  ? 418 GLY A O   1 
ATOM   2933 N N   . ARG A 1 393 ? 98.118  134.524 163.158 1.00 64.97  ? 419 ARG A N   1 
ATOM   2934 C CA  . ARG A 1 393 ? 96.798  133.957 163.404 1.00 69.01  ? 419 ARG A CA  1 
ATOM   2935 C C   . ARG A 1 393 ? 96.543  133.704 164.880 1.00 73.04  ? 419 ARG A C   1 
ATOM   2936 O O   . ARG A 1 393 ? 95.464  134.037 165.385 1.00 72.94  ? 419 ARG A O   1 
ATOM   2937 C CB  . ARG A 1 393 ? 96.631  132.652 162.610 1.00 68.05  ? 419 ARG A CB  1 
ATOM   2938 C CG  . ARG A 1 393 ? 95.271  131.994 162.772 1.00 71.74  ? 419 ARG A CG  1 
ATOM   2939 C CD  . ARG A 1 393 ? 95.226  130.644 162.075 1.00 73.50  ? 419 ARG A CD  1 
ATOM   2940 N NE  . ARG A 1 393 ? 96.193  129.709 162.638 1.00 78.11  ? 419 ARG A NE  1 
ATOM   2941 C CZ  . ARG A 1 393 ? 96.362  128.462 162.218 1.00 77.11  ? 419 ARG A CZ  1 
ATOM   2942 N NH1 . ARG A 1 393 ? 95.642  127.963 161.227 1.00 73.69  ? 419 ARG A NH1 1 
ATOM   2943 N NH2 . ARG A 1 393 ? 97.276  127.697 162.808 1.00 74.88  ? 419 ARG A NH2 1 
ATOM   2944 N N   . THR A 1 394 ? 97.509  133.124 165.590 1.00 73.08  ? 420 THR A N   1 
ATOM   2945 C CA  . THR A 1 394 ? 97.360  132.858 167.015 1.00 69.34  ? 420 THR A CA  1 
ATOM   2946 C C   . THR A 1 394 ? 97.959  133.957 167.881 1.00 68.66  ? 420 THR A C   1 
ATOM   2947 O O   . THR A 1 394 ? 97.429  134.243 168.961 1.00 68.36  ? 420 THR A O   1 
ATOM   2948 C CB  . THR A 1 394 ? 98.012  131.518 167.369 1.00 71.73  ? 420 THR A CB  1 
ATOM   2949 O OG1 . THR A 1 394 ? 97.595  130.520 166.430 1.00 74.41  ? 420 THR A OG1 1 
ATOM   2950 C CG2 . THR A 1 394 ? 97.611  131.079 168.770 1.00 68.86  ? 420 THR A CG2 1 
ATOM   2951 N N   . GLY A 1 395 ? 99.036  134.589 167.427 1.00 68.45  ? 421 GLY A N   1 
ATOM   2952 C CA  . GLY A 1 395 ? 99.725  135.589 168.213 1.00 64.42  ? 421 GLY A CA  1 
ATOM   2953 C C   . GLY A 1 395 ? 100.876 135.072 169.043 1.00 64.13  ? 421 GLY A C   1 
ATOM   2954 O O   . GLY A 1 395 ? 101.454 135.845 169.817 1.00 65.78  ? 421 GLY A O   1 
ATOM   2955 N N   . GLU A 1 396 ? 101.227 133.796 168.914 1.00 63.68  ? 422 GLU A N   1 
ATOM   2956 C CA  . GLU A 1 396 ? 102.331 133.235 169.677 1.00 63.53  ? 422 GLU A CA  1 
ATOM   2957 C C   . GLU A 1 396 ? 103.658 133.843 169.239 1.00 68.13  ? 422 GLU A C   1 
ATOM   2958 O O   . GLU A 1 396 ? 103.842 134.229 168.082 1.00 73.56  ? 422 GLU A O   1 
ATOM   2959 C CB  . GLU A 1 396 ? 102.373 131.716 169.516 1.00 68.93  ? 422 GLU A CB  1 
ATOM   2960 C CG  . GLU A 1 396 ? 101.130 131.005 170.026 1.00 71.29  ? 422 GLU A CG  1 
ATOM   2961 C CD  . GLU A 1 396 ? 101.218 129.499 169.878 1.00 75.53  ? 422 GLU A CD  1 
ATOM   2962 O OE1 . GLU A 1 396 ? 102.252 129.009 169.376 1.00 72.47  ? 422 GLU A OE1 1 
ATOM   2963 O OE2 . GLU A 1 396 ? 100.254 128.805 170.263 1.00 75.66  ? 422 GLU A OE2 1 
ATOM   2964 N N   . LEU A 1 397 ? 104.590 133.924 170.185 1.00 52.75  ? 423 LEU A N   1 
ATOM   2965 C CA  . LEU A 1 397 ? 105.901 134.516 169.962 1.00 52.65  ? 423 LEU A CA  1 
ATOM   2966 C C   . LEU A 1 397 ? 106.964 133.442 170.134 1.00 48.78  ? 423 LEU A C   1 
ATOM   2967 O O   . LEU A 1 397 ? 107.013 132.775 171.173 1.00 51.74  ? 423 LEU A O   1 
ATOM   2968 C CB  . LEU A 1 397 ? 106.151 135.671 170.934 1.00 52.93  ? 423 LEU A CB  1 
ATOM   2969 C CG  . LEU A 1 397 ? 107.281 136.640 170.590 1.00 52.34  ? 423 LEU A CG  1 
ATOM   2970 C CD1 . LEU A 1 397 ? 106.882 137.525 169.422 1.00 51.26  ? 423 LEU A CD1 1 
ATOM   2971 C CD2 . LEU A 1 397 ? 107.657 137.480 171.800 1.00 52.19  ? 423 LEU A CD2 1 
ATOM   2972 N N   . GLY A 1 398 ? 107.814 133.275 169.117 1.00 42.89  ? 424 GLY A N   1 
ATOM   2973 C CA  . GLY A 1 398 ? 108.851 132.268 169.162 1.00 42.18  ? 424 GLY A CA  1 
ATOM   2974 C C   . GLY A 1 398 ? 110.165 132.819 168.647 1.00 43.81  ? 424 GLY A C   1 
ATOM   2975 O O   . GLY A 1 398 ? 110.236 133.940 168.142 1.00 55.55  ? 424 GLY A O   1 
ATOM   2976 N N   . TYR A 1 399 ? 111.208 132.007 168.783 1.00 28.78  ? 425 TYR A N   1 
ATOM   2977 C CA  . TYR A 1 399 ? 112.561 132.401 168.419 1.00 31.04  ? 425 TYR A CA  1 
ATOM   2978 C C   . TYR A 1 399 ? 113.137 131.391 167.439 1.00 33.35  ? 425 TYR A C   1 
ATOM   2979 O O   . TYR A 1 399 ? 113.071 130.182 167.679 1.00 46.90  ? 425 TYR A O   1 
ATOM   2980 C CB  . TYR A 1 399 ? 113.451 132.509 169.660 1.00 36.43  ? 425 TYR A CB  1 
ATOM   2981 C CG  . TYR A 1 399 ? 112.903 133.433 170.723 1.00 36.54  ? 425 TYR A CG  1 
ATOM   2982 C CD1 . TYR A 1 399 ? 112.013 132.971 171.680 1.00 37.68  ? 425 TYR A CD1 1 
ATOM   2983 C CD2 . TYR A 1 399 ? 113.273 134.768 170.766 1.00 36.17  ? 425 TYR A CD2 1 
ATOM   2984 C CE1 . TYR A 1 399 ? 111.507 133.809 172.648 1.00 35.88  ? 425 TYR A CE1 1 
ATOM   2985 C CE2 . TYR A 1 399 ? 112.773 135.614 171.732 1.00 35.22  ? 425 TYR A CE2 1 
ATOM   2986 C CZ  . TYR A 1 399 ? 111.891 135.129 172.670 1.00 36.46  ? 425 TYR A CZ  1 
ATOM   2987 O OH  . TYR A 1 399 ? 111.390 135.969 173.635 1.00 45.02  ? 425 TYR A OH  1 
ATOM   2988 N N   . LEU A 1 400 ? 113.698 131.887 166.341 1.00 31.27  ? 426 LEU A N   1 
ATOM   2989 C CA  . LEU A 1 400 ? 114.315 131.029 165.343 1.00 33.81  ? 426 LEU A CA  1 
ATOM   2990 C C   . LEU A 1 400 ? 115.819 130.921 165.577 1.00 43.78  ? 426 LEU A C   1 
ATOM   2991 O O   . LEU A 1 400 ? 116.426 131.718 166.295 1.00 46.40  ? 426 LEU A O   1 
ATOM   2992 C CB  . LEU A 1 400 ? 114.042 131.555 163.934 1.00 31.85  ? 426 LEU A CB  1 
ATOM   2993 C CG  . LEU A 1 400 ? 112.589 131.592 163.464 1.00 40.15  ? 426 LEU A CG  1 
ATOM   2994 C CD1 . LEU A 1 400 ? 112.517 132.041 162.019 1.00 37.12  ? 426 LEU A CD1 1 
ATOM   2995 C CD2 . LEU A 1 400 ? 111.933 130.235 163.636 1.00 43.65  ? 426 LEU A CD2 1 
ATOM   2996 N N   . ASN A 1 401 ? 116.420 129.909 164.959 1.00 42.30  ? 427 ASN A N   1 
ATOM   2997 C CA  . ASN A 1 401 ? 117.866 129.787 164.969 1.00 33.87  ? 427 ASN A CA  1 
ATOM   2998 C C   . ASN A 1 401 ? 118.477 130.943 164.176 1.00 42.52  ? 427 ASN A C   1 
ATOM   2999 O O   . ASN A 1 401 ? 117.884 131.418 163.203 1.00 49.34  ? 427 ASN A O   1 
ATOM   3000 C CB  . ASN A 1 401 ? 118.293 128.453 164.365 1.00 33.64  ? 427 ASN A CB  1 
ATOM   3001 C CG  . ASN A 1 401 ? 119.397 127.778 165.154 1.00 39.18  ? 427 ASN A CG  1 
ATOM   3002 O OD1 . ASN A 1 401 ? 119.516 127.965 166.363 1.00 41.36  ? 427 ASN A OD1 1 
ATOM   3003 N ND2 . ASN A 1 401 ? 120.211 126.985 164.470 1.00 43.43  ? 427 ASN A ND2 1 
ATOM   3004 N N   . PRO A 1 402 ? 119.655 131.422 164.578 1.00 37.06  ? 428 PRO A N   1 
ATOM   3005 C CA  . PRO A 1 402 ? 120.226 132.608 163.925 1.00 36.29  ? 428 PRO A CA  1 
ATOM   3006 C C   . PRO A 1 402 ? 120.526 132.413 162.447 1.00 43.10  ? 428 PRO A C   1 
ATOM   3007 O O   . PRO A 1 402 ? 120.124 133.236 161.620 1.00 49.62  ? 428 PRO A O   1 
ATOM   3008 C CB  . PRO A 1 402 ? 121.512 132.857 164.723 1.00 35.88  ? 428 PRO A CB  1 
ATOM   3009 C CG  . PRO A 1 402 ? 121.260 132.230 166.045 1.00 36.73  ? 428 PRO A CG  1 
ATOM   3010 C CD  . PRO A 1 402 ? 120.438 131.014 165.755 1.00 41.03  ? 428 PRO A CD  1 
ATOM   3011 N N   . GLY A 1 403 ? 121.212 131.330 162.096 1.00 35.66  ? 429 GLY A N   1 
ATOM   3012 C CA  . GLY A 1 403 ? 121.645 131.144 160.726 1.00 34.18  ? 429 GLY A CA  1 
ATOM   3013 C C   . GLY A 1 403 ? 120.976 129.997 160.000 1.00 38.98  ? 429 GLY A C   1 
ATOM   3014 O O   . GLY A 1 403 ? 121.626 129.279 159.234 1.00 44.81  ? 429 GLY A O   1 
ATOM   3015 N N   . VAL A 1 404 ? 119.681 129.816 160.221 1.00 34.96  ? 430 VAL A N   1 
ATOM   3016 C CA  . VAL A 1 404 ? 118.958 128.711 159.603 1.00 30.13  ? 430 VAL A CA  1 
ATOM   3017 C C   . VAL A 1 404 ? 118.645 129.057 158.153 1.00 39.94  ? 430 VAL A C   1 
ATOM   3018 O O   . VAL A 1 404 ? 118.438 130.223 157.797 1.00 49.48  ? 430 VAL A O   1 
ATOM   3019 C CB  . VAL A 1 404 ? 117.681 128.384 160.404 1.00 31.25  ? 430 VAL A CB  1 
ATOM   3020 C CG1 . VAL A 1 404 ? 116.656 129.496 160.266 1.00 37.30  ? 430 VAL A CG1 1 
ATOM   3021 C CG2 . VAL A 1 404 ? 117.099 127.050 159.972 1.00 38.55  ? 430 VAL A CG2 1 
ATOM   3022 N N   . PHE A 1 405 ? 118.643 128.028 157.301 1.00 43.57  ? 431 PHE A N   1 
ATOM   3023 C CA  . PHE A 1 405 ? 118.338 128.163 155.876 1.00 37.44  ? 431 PHE A CA  1 
ATOM   3024 C C   . PHE A 1 405 ? 119.313 129.102 155.174 1.00 39.46  ? 431 PHE A C   1 
ATOM   3025 O O   . PHE A 1 405 ? 118.948 129.797 154.223 1.00 48.83  ? 431 PHE A O   1 
ATOM   3026 C CB  . PHE A 1 405 ? 116.897 128.632 155.656 1.00 38.60  ? 431 PHE A CB  1 
ATOM   3027 C CG  . PHE A 1 405 ? 115.868 127.757 156.308 1.00 39.75  ? 431 PHE A CG  1 
ATOM   3028 C CD1 . PHE A 1 405 ? 116.044 126.388 156.376 1.00 40.96  ? 431 PHE A CD1 1 
ATOM   3029 C CD2 . PHE A 1 405 ? 114.725 128.307 156.857 1.00 41.70  ? 431 PHE A CD2 1 
ATOM   3030 C CE1 . PHE A 1 405 ? 115.098 125.585 156.976 1.00 39.39  ? 431 PHE A CE1 1 
ATOM   3031 C CE2 . PHE A 1 405 ? 113.777 127.510 157.459 1.00 41.49  ? 431 PHE A CE2 1 
ATOM   3032 C CZ  . PHE A 1 405 ? 113.964 126.148 157.519 1.00 42.43  ? 431 PHE A CZ  1 
ATOM   3033 N N   . THR A 1 406 ? 120.561 129.131 155.634 1.00 42.92  ? 432 THR A N   1 
ATOM   3034 C CA  . THR A 1 406 ? 121.580 129.989 155.051 1.00 44.61  ? 432 THR A CA  1 
ATOM   3035 C C   . THR A 1 406 ? 122.893 129.224 154.982 1.00 51.01  ? 432 THR A C   1 
ATOM   3036 O O   . THR A 1 406 ? 123.134 128.291 155.752 1.00 55.24  ? 432 THR A O   1 
ATOM   3037 C CB  . THR A 1 406 ? 121.762 131.282 155.857 1.00 47.45  ? 432 THR A CB  1 
ATOM   3038 O OG1 . THR A 1 406 ? 120.492 131.725 156.347 1.00 53.22  ? 432 THR A OG1 1 
ATOM   3039 C CG2 . THR A 1 406 ? 122.357 132.376 154.986 1.00 50.58  ? 432 THR A CG2 1 
ATOM   3040 N N   . GLN A 1 407 ? 123.744 129.632 154.043 1.00 58.29  ? 433 GLN A N   1 
ATOM   3041 C CA  . GLN A 1 407 ? 125.065 129.049 153.885 1.00 54.39  ? 433 GLN A CA  1 
ATOM   3042 C C   . GLN A 1 407 ? 126.195 130.037 154.125 1.00 57.17  ? 433 GLN A C   1 
ATOM   3043 O O   . GLN A 1 407 ? 127.356 129.618 154.182 1.00 64.50  ? 433 GLN A O   1 
ATOM   3044 C CB  . GLN A 1 407 ? 125.215 128.439 152.483 1.00 53.83  ? 433 GLN A CB  1 
ATOM   3045 C CG  . GLN A 1 407 ? 124.245 127.304 152.206 1.00 56.77  ? 433 GLN A CG  1 
ATOM   3046 C CD  . GLN A 1 407 ? 124.305 126.818 150.774 1.00 61.60  ? 433 GLN A CD  1 
ATOM   3047 O OE1 . GLN A 1 407 ? 124.850 127.491 149.900 1.00 61.80  ? 433 GLN A OE1 1 
ATOM   3048 N NE2 . GLN A 1 407 ? 123.743 125.642 150.525 1.00 58.53  ? 433 GLN A NE2 1 
ATOM   3049 N N   . SER A 1 408 ? 125.896 131.325 154.268 1.00 53.07  ? 434 SER A N   1 
ATOM   3050 C CA  . SER A 1 408 ? 126.886 132.343 154.580 1.00 55.72  ? 434 SER A CA  1 
ATOM   3051 C C   . SER A 1 408 ? 126.421 133.139 155.791 1.00 58.89  ? 434 SER A C   1 
ATOM   3052 O O   . SER A 1 408 ? 125.303 132.970 156.284 1.00 64.79  ? 434 SER A O   1 
ATOM   3053 C CB  . SER A 1 408 ? 127.127 133.276 153.388 1.00 61.19  ? 434 SER A CB  1 
ATOM   3054 O OG  . SER A 1 408 ? 128.089 134.267 153.703 1.00 70.29  ? 434 SER A OG  1 
ATOM   3055 N N   . ARG A 1 409 ? 127.298 134.019 156.275 1.00 58.13  ? 435 ARG A N   1 
ATOM   3056 C CA  . ARG A 1 409 ? 127.010 134.837 157.447 1.00 55.38  ? 435 ARG A CA  1 
ATOM   3057 C C   . ARG A 1 409 ? 127.238 136.318 157.165 1.00 63.12  ? 435 ARG A C   1 
ATOM   3058 O O   . ARG A 1 409 ? 127.581 137.081 158.071 1.00 69.87  ? 435 ARG A O   1 
ATOM   3059 C CB  . ARG A 1 409 ? 127.842 134.382 158.645 1.00 58.05  ? 435 ARG A CB  1 
ATOM   3060 C CG  . ARG A 1 409 ? 129.334 134.314 158.379 1.00 64.79  ? 435 ARG A CG  1 
ATOM   3061 C CD  . ARG A 1 409 ? 130.082 133.793 159.595 1.00 67.49  ? 435 ARG A CD  1 
ATOM   3062 N NE  . ARG A 1 409 ? 129.621 132.467 159.991 1.00 69.45  ? 435 ARG A NE  1 
ATOM   3063 C CZ  . ARG A 1 409 ? 130.095 131.787 161.026 1.00 68.78  ? 435 ARG A CZ  1 
ATOM   3064 N NH1 . ARG A 1 409 ? 131.049 132.280 161.798 1.00 68.13  ? 435 ARG A NH1 1 
ATOM   3065 N NH2 . ARG A 1 409 ? 129.597 130.583 161.294 1.00 62.02  ? 435 ARG A NH2 1 
ATOM   3066 N N   . ARG A 1 410 ? 127.054 136.742 155.917 1.00 56.14  ? 436 ARG A N   1 
ATOM   3067 C CA  . ARG A 1 410 ? 127.177 138.146 155.551 1.00 52.10  ? 436 ARG A CA  1 
ATOM   3068 C C   . ARG A 1 410 ? 125.853 138.895 155.607 1.00 54.71  ? 436 ARG A C   1 
ATOM   3069 O O   . ARG A 1 410 ? 125.831 140.102 155.345 1.00 57.56  ? 436 ARG A O   1 
ATOM   3070 C CB  . ARG A 1 410 ? 127.768 138.284 154.145 1.00 53.66  ? 436 ARG A CB  1 
ATOM   3071 C CG  . ARG A 1 410 ? 129.263 138.056 154.056 1.00 55.99  ? 436 ARG A CG  1 
ATOM   3072 C CD  . ARG A 1 410 ? 129.793 138.558 152.723 1.00 58.45  ? 436 ARG A CD  1 
ATOM   3073 N NE  . ARG A 1 410 ? 131.228 138.354 152.585 1.00 58.36  ? 436 ARG A NE  1 
ATOM   3074 C CZ  . ARG A 1 410 ? 131.946 138.778 151.554 1.00 59.17  ? 436 ARG A CZ  1 
ATOM   3075 N NH1 . ARG A 1 410 ? 131.392 139.444 150.555 1.00 57.78  ? 436 ARG A NH1 1 
ATOM   3076 N NH2 . ARG A 1 410 ? 133.252 138.528 151.526 1.00 60.88  ? 436 ARG A NH2 1 
ATOM   3077 N N   . TRP A 1 411 ? 124.756 138.219 155.939 1.00 42.13  ? 437 TRP A N   1 
ATOM   3078 C CA  . TRP A 1 411 ? 123.451 138.862 155.990 1.00 45.51  ? 437 TRP A CA  1 
ATOM   3079 C C   . TRP A 1 411 ? 123.246 139.700 157.244 1.00 52.40  ? 437 TRP A C   1 
ATOM   3080 O O   . TRP A 1 411 ? 122.220 140.379 157.353 1.00 55.96  ? 437 TRP A O   1 
ATOM   3081 C CB  . TRP A 1 411 ? 122.347 137.808 155.890 1.00 46.15  ? 437 TRP A CB  1 
ATOM   3082 C CG  . TRP A 1 411 ? 122.494 136.710 156.884 1.00 45.62  ? 437 TRP A CG  1 
ATOM   3083 C CD1 . TRP A 1 411 ? 123.150 135.530 156.709 1.00 50.29  ? 437 TRP A CD1 1 
ATOM   3084 C CD2 . TRP A 1 411 ? 121.980 136.690 158.218 1.00 42.63  ? 437 TRP A CD2 1 
ATOM   3085 N NE1 . TRP A 1 411 ? 123.075 134.773 157.851 1.00 52.23  ? 437 TRP A NE1 1 
ATOM   3086 C CE2 . TRP A 1 411 ? 122.361 135.464 158.793 1.00 44.53  ? 437 TRP A CE2 1 
ATOM   3087 C CE3 . TRP A 1 411 ? 121.233 137.589 158.982 1.00 49.01  ? 437 TRP A CE3 1 
ATOM   3088 C CZ2 . TRP A 1 411 ? 122.023 135.117 160.096 1.00 47.79  ? 437 TRP A CZ2 1 
ATOM   3089 C CZ3 . TRP A 1 411 ? 120.898 137.242 160.272 1.00 49.21  ? 437 TRP A CZ3 1 
ATOM   3090 C CH2 . TRP A 1 411 ? 121.292 136.017 160.817 1.00 45.55  ? 437 TRP A CH2 1 
ATOM   3091 N N   . LYS A 1 412 ? 124.187 139.672 158.185 1.00 52.04  ? 438 LYS A N   1 
ATOM   3092 C CA  . LYS A 1 412 ? 124.064 140.430 159.422 1.00 47.53  ? 438 LYS A CA  1 
ATOM   3093 C C   . LYS A 1 412 ? 124.526 141.872 159.283 1.00 53.71  ? 438 LYS A C   1 
ATOM   3094 O O   . LYS A 1 412 ? 124.409 142.637 160.247 1.00 57.61  ? 438 LYS A O   1 
ATOM   3095 C CB  . LYS A 1 412 ? 124.871 139.760 160.536 1.00 45.75  ? 438 LYS A CB  1 
ATOM   3096 C CG  . LYS A 1 412 ? 124.703 138.258 160.640 1.00 50.77  ? 438 LYS A CG  1 
ATOM   3097 C CD  . LYS A 1 412 ? 125.663 137.686 161.669 1.00 55.45  ? 438 LYS A CD  1 
ATOM   3098 C CE  . LYS A 1 412 ? 125.541 136.177 161.769 1.00 57.49  ? 438 LYS A CE  1 
ATOM   3099 N NZ  . LYS A 1 412 ? 126.491 135.615 162.767 1.00 56.61  ? 438 LYS A NZ  1 
ATOM   3100 N N   . ASP A 1 413 ? 125.045 142.265 158.121 1.00 50.92  ? 439 ASP A N   1 
ATOM   3101 C CA  . ASP A 1 413 ? 125.665 143.571 157.967 1.00 46.83  ? 439 ASP A CA  1 
ATOM   3102 C C   . ASP A 1 413 ? 125.110 144.390 156.811 1.00 50.07  ? 439 ASP A C   1 
ATOM   3103 O O   . ASP A 1 413 ? 125.557 145.525 156.613 1.00 52.61  ? 439 ASP A O   1 
ATOM   3104 C CB  . ASP A 1 413 ? 127.180 143.413 157.788 1.00 48.94  ? 439 ASP A CB  1 
ATOM   3105 C CG  . ASP A 1 413 ? 127.813 142.604 158.901 1.00 57.55  ? 439 ASP A CG  1 
ATOM   3106 O OD1 . ASP A 1 413 ? 127.411 142.783 160.069 1.00 55.96  ? 439 ASP A OD1 1 
ATOM   3107 O OD2 . ASP A 1 413 ? 128.707 141.783 158.609 1.00 61.76  ? 439 ASP A OD2 1 
ATOM   3108 N N   . HIS A 1 414 ? 124.160 143.861 156.046 1.00 52.30  ? 440 HIS A N   1 
ATOM   3109 C CA  . HIS A 1 414 ? 123.580 144.577 154.921 1.00 49.83  ? 440 HIS A CA  1 
ATOM   3110 C C   . HIS A 1 414 ? 122.064 144.504 154.993 1.00 53.13  ? 440 HIS A C   1 
ATOM   3111 O O   . HIS A 1 414 ? 121.497 143.447 155.286 1.00 59.15  ? 440 HIS A O   1 
ATOM   3112 C CB  . HIS A 1 414 ? 124.075 144.010 153.589 1.00 50.36  ? 440 HIS A CB  1 
ATOM   3113 C CG  . HIS A 1 414 ? 125.560 144.077 153.419 1.00 52.89  ? 440 HIS A CG  1 
ATOM   3114 N ND1 . HIS A 1 414 ? 126.411 143.114 153.916 1.00 51.09  ? 440 HIS A ND1 1 
ATOM   3115 C CD2 . HIS A 1 414 ? 126.347 144.997 152.812 1.00 53.93  ? 440 HIS A CD2 1 
ATOM   3116 C CE1 . HIS A 1 414 ? 127.657 143.435 153.619 1.00 50.19  ? 440 HIS A CE1 1 
ATOM   3117 N NE2 . HIS A 1 414 ? 127.647 144.573 152.950 1.00 51.16  ? 440 HIS A NE2 1 
ATOM   3118 N N   . ALA A 1 415 ? 121.410 145.636 154.724 1.00 45.99  ? 441 ALA A N   1 
ATOM   3119 C CA  . ALA A 1 415 ? 119.955 145.685 154.803 1.00 42.57  ? 441 ALA A CA  1 
ATOM   3120 C C   . ALA A 1 415 ? 119.297 144.901 153.675 1.00 53.01  ? 441 ALA A C   1 
ATOM   3121 O O   . ALA A 1 415 ? 118.243 144.289 153.883 1.00 58.90  ? 441 ALA A O   1 
ATOM   3122 C CB  . ALA A 1 415 ? 119.477 147.135 154.789 1.00 45.97  ? 441 ALA A CB  1 
ATOM   3123 N N   . ASP A 1 416 ? 119.892 144.910 152.481 1.00 52.19  ? 442 ASP A N   1 
ATOM   3124 C CA  . ASP A 1 416 ? 119.309 144.190 151.352 1.00 47.92  ? 442 ASP A CA  1 
ATOM   3125 C C   . ASP A 1 416 ? 119.302 142.687 151.596 1.00 48.06  ? 442 ASP A C   1 
ATOM   3126 O O   . ASP A 1 416 ? 118.295 142.008 151.351 1.00 53.87  ? 442 ASP A O   1 
ATOM   3127 C CB  . ASP A 1 416 ? 120.078 144.520 150.075 1.00 50.76  ? 442 ASP A CB  1 
ATOM   3128 C CG  . ASP A 1 416 ? 121.575 144.531 150.287 1.00 55.50  ? 442 ASP A CG  1 
ATOM   3129 O OD1 . ASP A 1 416 ? 122.026 145.111 151.296 1.00 54.60  ? 442 ASP A OD1 1 
ATOM   3130 O OD2 . ASP A 1 416 ? 122.302 143.956 149.450 1.00 63.33  ? 442 ASP A OD2 1 
ATOM   3131 N N   . MET A 1 417 ? 120.421 142.147 152.080 1.00 42.73  ? 443 MET A N   1 
ATOM   3132 C CA  . MET A 1 417 ? 120.478 140.720 152.363 1.00 44.07  ? 443 MET A CA  1 
ATOM   3133 C C   . MET A 1 417 ? 119.558 140.350 153.515 1.00 44.26  ? 443 MET A C   1 
ATOM   3134 O O   . MET A 1 417 ? 118.964 139.266 153.509 1.00 54.30  ? 443 MET A O   1 
ATOM   3135 C CB  . MET A 1 417 ? 121.918 140.302 152.658 1.00 45.62  ? 443 MET A CB  1 
ATOM   3136 C CG  . MET A 1 417 ? 122.862 140.493 151.480 1.00 46.74  ? 443 MET A CG  1 
ATOM   3137 S SD  . MET A 1 417 ? 124.551 139.975 151.827 1.00 53.65  ? 443 MET A SD  1 
ATOM   3138 C CE  . MET A 1 417 ? 124.270 138.312 152.425 1.00 51.23  ? 443 MET A CE  1 
ATOM   3139 N N   . LEU A 1 418 ? 119.405 141.243 154.494 1.00 39.95  ? 444 LEU A N   1 
ATOM   3140 C CA  . LEU A 1 418 ? 118.459 140.995 155.575 1.00 36.03  ? 444 LEU A CA  1 
ATOM   3141 C C   . LEU A 1 418 ? 117.027 140.957 155.055 1.00 42.73  ? 444 LEU A C   1 
ATOM   3142 O O   . LEU A 1 418 ? 116.230 140.117 155.484 1.00 54.99  ? 444 LEU A O   1 
ATOM   3143 C CB  . LEU A 1 418 ? 118.607 142.058 156.660 1.00 28.75  ? 444 LEU A CB  1 
ATOM   3144 C CG  . LEU A 1 418 ? 117.910 141.736 157.979 1.00 37.77  ? 444 LEU A CG  1 
ATOM   3145 C CD1 . LEU A 1 418 ? 118.606 140.577 158.666 1.00 40.65  ? 444 LEU A CD1 1 
ATOM   3146 C CD2 . LEU A 1 418 ? 117.872 142.954 158.883 1.00 46.64  ? 444 LEU A CD2 1 
ATOM   3147 N N   . LYS A 1 419 ? 116.681 141.861 154.135 1.00 37.15  ? 445 LYS A N   1 
ATOM   3148 C CA  . LYS A 1 419 ? 115.340 141.854 153.556 1.00 33.13  ? 445 LYS A CA  1 
ATOM   3149 C C   . LYS A 1 419 ? 115.094 140.583 152.752 1.00 43.27  ? 445 LYS A C   1 
ATOM   3150 O O   . LYS A 1 419 ? 114.010 139.988 152.829 1.00 53.10  ? 445 LYS A O   1 
ATOM   3151 C CB  . LYS A 1 419 ? 115.147 143.092 152.682 1.00 35.47  ? 445 LYS A CB  1 
ATOM   3152 C CG  . LYS A 1 419 ? 113.733 143.304 152.178 1.00 33.35  ? 445 LYS A CG  1 
ATOM   3153 C CD  . LYS A 1 419 ? 112.870 143.991 153.218 1.00 35.97  ? 445 LYS A CD  1 
ATOM   3154 C CE  . LYS A 1 419 ? 111.493 144.306 152.671 1.00 41.32  ? 445 LYS A CE  1 
ATOM   3155 N NZ  . LYS A 1 419 ? 110.768 143.077 152.260 1.00 40.23  ? 445 LYS A NZ  1 
ATOM   3156 N N   . GLN A 1 420 ? 116.092 140.150 151.978 1.00 45.68  ? 446 GLN A N   1 
ATOM   3157 C CA  . GLN A 1 420 ? 115.951 138.907 151.223 1.00 40.53  ? 446 GLN A CA  1 
ATOM   3158 C C   . GLN A 1 420 ? 115.788 137.710 152.152 1.00 44.58  ? 446 GLN A C   1 
ATOM   3159 O O   . GLN A 1 420 ? 114.964 136.825 151.894 1.00 53.15  ? 446 GLN A O   1 
ATOM   3160 C CB  . GLN A 1 420 ? 117.153 138.712 150.301 1.00 40.81  ? 446 GLN A CB  1 
ATOM   3161 C CG  . GLN A 1 420 ? 117.190 139.665 149.121 1.00 47.45  ? 446 GLN A CG  1 
ATOM   3162 C CD  . GLN A 1 420 ? 118.335 139.372 148.177 1.00 50.60  ? 446 GLN A CD  1 
ATOM   3163 O OE1 . GLN A 1 420 ? 119.350 138.804 148.574 1.00 46.88  ? 446 GLN A OE1 1 
ATOM   3164 N NE2 . GLN A 1 420 ? 118.176 139.755 146.916 1.00 51.52  ? 446 GLN A NE2 1 
ATOM   3165 N N   . TYR A 1 421 ? 116.560 137.670 153.240 1.00 39.76  ? 447 TYR A N   1 
ATOM   3166 C CA  . TYR A 1 421 ? 116.433 136.585 154.206 1.00 34.12  ? 447 TYR A CA  1 
ATOM   3167 C C   . TYR A 1 421 ? 115.072 136.611 154.888 1.00 36.81  ? 447 TYR A C   1 
ATOM   3168 O O   . TYR A 1 421 ? 114.479 135.557 155.146 1.00 51.63  ? 447 TYR A O   1 
ATOM   3169 C CB  . TYR A 1 421 ? 117.563 136.677 155.230 1.00 38.51  ? 447 TYR A CB  1 
ATOM   3170 C CG  . TYR A 1 421 ? 117.624 135.532 156.211 1.00 42.12  ? 447 TYR A CG  1 
ATOM   3171 C CD1 . TYR A 1 421 ? 117.671 134.218 155.773 1.00 42.45  ? 447 TYR A CD1 1 
ATOM   3172 C CD2 . TYR A 1 421 ? 117.662 135.767 157.576 1.00 45.19  ? 447 TYR A CD2 1 
ATOM   3173 C CE1 . TYR A 1 421 ? 117.734 133.172 156.669 1.00 42.98  ? 447 TYR A CE1 1 
ATOM   3174 C CE2 . TYR A 1 421 ? 117.729 134.728 158.478 1.00 37.41  ? 447 TYR A CE2 1 
ATOM   3175 C CZ  . TYR A 1 421 ? 117.763 133.433 158.020 1.00 39.42  ? 447 TYR A CZ  1 
ATOM   3176 O OH  . TYR A 1 421 ? 117.828 132.395 158.918 1.00 49.59  ? 447 TYR A OH  1 
ATOM   3177 N N   . ALA A 1 422 ? 114.555 137.807 155.177 1.00 31.61  ? 448 ALA A N   1 
ATOM   3178 C CA  . ALA A 1 422 ? 113.233 137.918 155.781 1.00 32.76  ? 448 ALA A CA  1 
ATOM   3179 C C   . ALA A 1 422 ? 112.151 137.408 154.840 1.00 38.80  ? 448 ALA A C   1 
ATOM   3180 O O   . ALA A 1 422 ? 111.231 136.706 155.269 1.00 53.40  ? 448 ALA A O   1 
ATOM   3181 C CB  . ALA A 1 422 ? 112.959 139.367 156.181 1.00 38.45  ? 448 ALA A CB  1 
ATOM   3182 N N   . THR A 1 423 ? 112.251 137.737 153.550 1.00 34.10  ? 449 THR A N   1 
ATOM   3183 C CA  . THR A 1 423 ? 111.274 137.232 152.586 1.00 34.24  ? 449 THR A CA  1 
ATOM   3184 C C   . THR A 1 423 ? 111.376 135.717 152.435 1.00 46.53  ? 449 THR A C   1 
ATOM   3185 O O   . THR A 1 423 ? 110.354 135.018 152.357 1.00 50.35  ? 449 THR A O   1 
ATOM   3186 C CB  . THR A 1 423 ? 111.468 137.920 151.236 1.00 35.96  ? 449 THR A CB  1 
ATOM   3187 O OG1 . THR A 1 423 ? 111.385 139.340 151.408 1.00 45.11  ? 449 THR A OG1 1 
ATOM   3188 C CG2 . THR A 1 423 ? 110.400 137.473 150.251 1.00 38.62  ? 449 THR A CG2 1 
ATOM   3189 N N   . CYS A 1 424 ? 112.603 135.192 152.402 1.00 50.22  ? 450 CYS A N   1 
ATOM   3190 C CA  . CYS A 1 424 ? 112.795 133.748 152.315 1.00 41.28  ? 450 CYS A CA  1 
ATOM   3191 C C   . CYS A 1 424 ? 112.183 133.040 153.516 1.00 45.93  ? 450 CYS A C   1 
ATOM   3192 O O   . CYS A 1 424 ? 111.512 132.012 153.367 1.00 51.18  ? 450 CYS A O   1 
ATOM   3193 C CB  . CYS A 1 424 ? 114.285 133.431 152.213 1.00 47.05  ? 450 CYS A CB  1 
ATOM   3194 S SG  . CYS A 1 424 ? 114.687 131.682 152.072 1.00 73.72  ? 450 CYS A SG  1 
ATOM   3195 N N   . LEU A 1 425 ? 112.393 133.582 154.717 1.00 45.27  ? 451 LEU A N   1 
ATOM   3196 C CA  . LEU A 1 425 ? 111.794 132.986 155.905 1.00 40.98  ? 451 LEU A CA  1 
ATOM   3197 C C   . LEU A 1 425 ? 110.277 133.112 155.878 1.00 43.33  ? 451 LEU A C   1 
ATOM   3198 O O   . LEU A 1 425 ? 109.567 132.189 156.290 1.00 56.42  ? 451 LEU A O   1 
ATOM   3199 C CB  . LEU A 1 425 ? 112.365 133.629 157.166 1.00 37.26  ? 451 LEU A CB  1 
ATOM   3200 C CG  . LEU A 1 425 ? 113.790 133.228 157.543 1.00 42.18  ? 451 LEU A CG  1 
ATOM   3201 C CD1 . LEU A 1 425 ? 114.217 133.927 158.818 1.00 42.24  ? 451 LEU A CD1 1 
ATOM   3202 C CD2 . LEU A 1 425 ? 113.890 131.721 157.700 1.00 48.21  ? 451 LEU A CD2 1 
ATOM   3203 N N   . SER A 1 426 ? 109.761 134.240 155.389 1.00 33.99  ? 452 SER A N   1 
ATOM   3204 C CA  . SER A 1 426 ? 108.319 134.428 155.328 1.00 34.67  ? 452 SER A CA  1 
ATOM   3205 C C   . SER A 1 426 ? 107.657 133.475 154.348 1.00 38.94  ? 452 SER A C   1 
ATOM   3206 O O   . SER A 1 426 ? 106.473 133.164 154.511 1.00 40.69  ? 452 SER A O   1 
ATOM   3207 C CB  . SER A 1 426 ? 107.989 135.870 154.947 1.00 41.62  ? 452 SER A CB  1 
ATOM   3208 O OG  . SER A 1 426 ? 106.591 136.055 154.829 1.00 48.34  ? 452 SER A OG  1 
ATOM   3209 N N   . ARG A 1 427 ? 108.385 133.007 153.337 1.00 49.37  ? 453 ARG A N   1 
ATOM   3210 C CA  . ARG A 1 427 ? 107.806 132.023 152.430 1.00 47.11  ? 453 ARG A CA  1 
ATOM   3211 C C   . ARG A 1 427 ? 108.125 130.585 152.819 1.00 49.01  ? 453 ARG A C   1 
ATOM   3212 O O   . ARG A 1 427 ? 107.448 129.669 152.342 1.00 52.32  ? 453 ARG A O   1 
ATOM   3213 C CB  . ARG A 1 427 ? 108.270 132.273 150.991 1.00 48.97  ? 453 ARG A CB  1 
ATOM   3214 C CG  . ARG A 1 427 ? 109.688 131.826 150.693 1.00 54.35  ? 453 ARG A CG  1 
ATOM   3215 C CD  . ARG A 1 427 ? 109.954 131.825 149.196 1.00 54.44  ? 453 ARG A CD  1 
ATOM   3216 N NE  . ARG A 1 427 ? 111.312 131.397 148.882 1.00 56.32  ? 453 ARG A NE  1 
ATOM   3217 C CZ  . ARG A 1 427 ? 111.685 130.133 148.741 1.00 56.49  ? 453 ARG A CZ  1 
ATOM   3218 N NH1 . ARG A 1 427 ? 110.824 129.138 148.878 1.00 53.65  ? 453 ARG A NH1 1 
ATOM   3219 N NH2 . ARG A 1 427 ? 112.955 129.859 148.455 1.00 53.74  ? 453 ARG A NH2 1 
ATOM   3220 N N   . LEU A 1 428 ? 109.131 130.362 153.667 1.00 47.01  ? 454 LEU A N   1 
ATOM   3221 C CA  . LEU A 1 428 ? 109.467 129.008 154.095 1.00 42.55  ? 454 LEU A CA  1 
ATOM   3222 C C   . LEU A 1 428 ? 108.769 128.583 155.381 1.00 52.40  ? 454 LEU A C   1 
ATOM   3223 O O   . LEU A 1 428 ? 108.516 127.387 155.567 1.00 58.79  ? 454 LEU A O   1 
ATOM   3224 C CB  . LEU A 1 428 ? 110.980 128.871 154.283 1.00 42.44  ? 454 LEU A CB  1 
ATOM   3225 C CG  . LEU A 1 428 ? 111.808 128.656 153.017 1.00 53.19  ? 454 LEU A CG  1 
ATOM   3226 C CD1 . LEU A 1 428 ? 113.284 128.581 153.355 1.00 52.91  ? 454 LEU A CD1 1 
ATOM   3227 C CD2 . LEU A 1 428 ? 111.360 127.394 152.299 1.00 51.68  ? 454 LEU A CD2 1 
ATOM   3228 N N   . LEU A 1 429 ? 108.454 129.522 156.272 1.00 54.36  ? 455 LEU A N   1 
ATOM   3229 C CA  . LEU A 1 429 ? 107.883 129.153 157.563 1.00 49.33  ? 455 LEU A CA  1 
ATOM   3230 C C   . LEU A 1 429 ? 106.502 128.499 157.498 1.00 50.30  ? 455 LEU A C   1 
ATOM   3231 O O   . LEU A 1 429 ? 106.203 127.703 158.405 1.00 55.72  ? 455 LEU A O   1 
ATOM   3232 C CB  . LEU A 1 429 ? 107.835 130.384 158.479 1.00 46.30  ? 455 LEU A CB  1 
ATOM   3233 C CG  . LEU A 1 429 ? 109.152 130.780 159.148 1.00 44.79  ? 455 LEU A CG  1 
ATOM   3234 C CD1 . LEU A 1 429 ? 108.927 131.898 160.150 1.00 50.24  ? 455 LEU A CD1 1 
ATOM   3235 C CD2 . LEU A 1 429 ? 109.799 129.582 159.816 1.00 49.01  ? 455 LEU A CD2 1 
ATOM   3236 N N   . PRO A 1 430 ? 105.630 128.772 156.519 1.00 41.99  ? 456 PRO A N   1 
ATOM   3237 C CA  . PRO A 1 430 ? 104.344 128.056 156.488 1.00 44.62  ? 456 PRO A CA  1 
ATOM   3238 C C   . PRO A 1 430 ? 104.481 126.550 156.364 1.00 51.41  ? 456 PRO A C   1 
ATOM   3239 O O   . PRO A 1 430 ? 103.518 125.832 156.657 1.00 55.25  ? 456 PRO A O   1 
ATOM   3240 C CB  . PRO A 1 430 ? 103.641 128.657 155.267 1.00 51.34  ? 456 PRO A CB  1 
ATOM   3241 C CG  . PRO A 1 430 ? 104.166 130.031 155.199 1.00 53.52  ? 456 PRO A CG  1 
ATOM   3242 C CD  . PRO A 1 430 ? 105.608 129.936 155.613 1.00 48.15  ? 456 PRO A CD  1 
ATOM   3243 N N   . LYS A 1 431 ? 105.642 126.048 155.945 1.00 51.69  ? 457 LYS A N   1 
ATOM   3244 C CA  . LYS A 1 431 ? 105.882 124.612 155.918 1.00 45.77  ? 457 LYS A CA  1 
ATOM   3245 C C   . LYS A 1 431 ? 106.027 124.019 157.314 1.00 49.07  ? 457 LYS A C   1 
ATOM   3246 O O   . LYS A 1 431 ? 105.945 122.795 157.461 1.00 49.95  ? 457 LYS A O   1 
ATOM   3247 C CB  . LYS A 1 431 ? 107.131 124.319 155.083 1.00 45.78  ? 457 LYS A CB  1 
ATOM   3248 C CG  . LYS A 1 431 ? 107.300 122.870 154.667 1.00 51.03  ? 457 LYS A CG  1 
ATOM   3249 C CD  . LYS A 1 431 ? 108.376 122.731 153.602 1.00 52.89  ? 457 LYS A CD  1 
ATOM   3250 C CE  . LYS A 1 431 ? 109.686 123.352 154.054 1.00 55.87  ? 457 LYS A CE  1 
ATOM   3251 N NZ  . LYS A 1 431 ? 110.732 123.280 152.996 1.00 55.50  ? 457 LYS A NZ  1 
ATOM   3252 N N   . TYR A 1 432 ? 106.221 124.850 158.337 1.00 55.58  ? 458 TYR A N   1 
ATOM   3253 C CA  . TYR A 1 432 ? 106.404 124.400 159.713 1.00 51.73  ? 458 TYR A CA  1 
ATOM   3254 C C   . TYR A 1 432 ? 105.255 124.852 160.612 1.00 52.73  ? 458 TYR A C   1 
ATOM   3255 O O   . TYR A 1 432 ? 105.460 125.212 161.772 1.00 51.11  ? 458 TYR A O   1 
ATOM   3256 C CB  . TYR A 1 432 ? 107.737 124.893 160.268 1.00 46.36  ? 458 TYR A CB  1 
ATOM   3257 C CG  . TYR A 1 432 ? 108.943 124.400 159.503 1.00 43.08  ? 458 TYR A CG  1 
ATOM   3258 C CD1 . TYR A 1 432 ? 109.448 125.116 158.429 1.00 47.05  ? 458 TYR A CD1 1 
ATOM   3259 C CD2 . TYR A 1 432 ? 109.578 123.221 159.858 1.00 45.25  ? 458 TYR A CD2 1 
ATOM   3260 C CE1 . TYR A 1 432 ? 110.550 124.671 157.729 1.00 48.57  ? 458 TYR A CE1 1 
ATOM   3261 C CE2 . TYR A 1 432 ? 110.681 122.767 159.164 1.00 48.61  ? 458 TYR A CE2 1 
ATOM   3262 C CZ  . TYR A 1 432 ? 111.163 123.496 158.101 1.00 50.43  ? 458 TYR A CZ  1 
ATOM   3263 O OH  . TYR A 1 432 ? 112.261 123.049 157.405 1.00 52.86  ? 458 TYR A OH  1 
ATOM   3264 N N   . ASN A 1 433 ? 104.033 124.841 160.075 1.00 68.81  ? 459 ASN A N   1 
ATOM   3265 C CA  . ASN A 1 433 ? 102.821 125.169 160.832 1.00 67.48  ? 459 ASN A CA  1 
ATOM   3266 C C   . ASN A 1 433 ? 102.884 126.574 161.428 1.00 70.86  ? 459 ASN A C   1 
ATOM   3267 O O   . ASN A 1 433 ? 102.477 126.802 162.569 1.00 75.72  ? 459 ASN A O   1 
ATOM   3268 C CB  . ASN A 1 433 ? 102.548 124.130 161.921 1.00 69.49  ? 459 ASN A CB  1 
ATOM   3269 C CG  . ASN A 1 433 ? 102.049 122.816 161.358 1.00 76.63  ? 459 ASN A CG  1 
ATOM   3270 O OD1 . ASN A 1 433 ? 101.369 122.786 160.334 1.00 78.10  ? 459 ASN A OD1 1 
ATOM   3271 N ND2 . ASN A 1 433 ? 102.386 121.720 162.027 1.00 82.05  ? 459 ASN A ND2 1 
ATOM   3272 N N   . VAL A 1 434 ? 103.400 127.523 160.653 1.00 61.88  ? 460 VAL A N   1 
ATOM   3273 C CA  . VAL A 1 434 ? 103.424 128.931 161.029 1.00 59.24  ? 460 VAL A CA  1 
ATOM   3274 C C   . VAL A 1 434 ? 102.638 129.713 159.985 1.00 62.33  ? 460 VAL A C   1 
ATOM   3275 O O   . VAL A 1 434 ? 102.884 129.569 158.783 1.00 67.06  ? 460 VAL A O   1 
ATOM   3276 C CB  . VAL A 1 434 ? 104.862 129.466 161.147 1.00 55.96  ? 460 VAL A CB  1 
ATOM   3277 C CG1 . VAL A 1 434 ? 104.852 130.931 161.536 1.00 56.49  ? 460 VAL A CG1 1 
ATOM   3278 C CG2 . VAL A 1 434 ? 105.646 128.652 162.160 1.00 59.24  ? 460 VAL A CG2 1 
ATOM   3279 N N   . THR A 1 435 ? 101.701 130.537 160.441 1.00 59.47  ? 461 THR A N   1 
ATOM   3280 C CA  . THR A 1 435 ? 100.922 131.375 159.539 1.00 59.24  ? 461 THR A CA  1 
ATOM   3281 C C   . THR A 1 435 ? 101.766 132.586 159.151 1.00 63.37  ? 461 THR A C   1 
ATOM   3282 O O   . THR A 1 435 ? 102.975 132.625 159.395 1.00 68.43  ? 461 THR A O   1 
ATOM   3283 C CB  . THR A 1 435 ? 99.597  131.770 160.181 1.00 64.28  ? 461 THR A CB  1 
ATOM   3284 O OG1 . THR A 1 435 ? 99.844  132.577 161.339 1.00 70.78  ? 461 THR A OG1 1 
ATOM   3285 C CG2 . THR A 1 435 ? 98.818  130.530 160.590 1.00 63.43  ? 461 THR A CG2 1 
ATOM   3286 N N   . GLU A 1 436 ? 101.139 133.587 158.525 1.00 55.36  ? 462 GLU A N   1 
ATOM   3287 C CA  . GLU A 1 436 ? 101.844 134.767 158.034 1.00 54.25  ? 462 GLU A CA  1 
ATOM   3288 C C   . GLU A 1 436 ? 102.619 135.429 159.167 1.00 54.82  ? 462 GLU A C   1 
ATOM   3289 O O   . GLU A 1 436 ? 102.018 136.031 160.065 1.00 60.35  ? 462 GLU A O   1 
ATOM   3290 C CB  . GLU A 1 436 ? 100.857 135.756 157.415 1.00 57.05  ? 462 GLU A CB  1 
ATOM   3291 C CG  . GLU A 1 436 ? 99.971  135.152 156.340 1.00 62.84  ? 462 GLU A CG  1 
ATOM   3292 C CD  . GLU A 1 436 ? 98.905  136.115 155.857 1.00 66.83  ? 462 GLU A CD  1 
ATOM   3293 O OE1 . GLU A 1 436 ? 98.860  137.255 156.363 1.00 65.40  ? 462 GLU A OE1 1 
ATOM   3294 O OE2 . GLU A 1 436 ? 98.112  135.731 154.971 1.00 64.76  ? 462 GLU A OE2 1 
ATOM   3295 N N   . PRO A 1 437 ? 103.946 135.344 159.156 1.00 45.60  ? 463 PRO A N   1 
ATOM   3296 C CA  . PRO A 1 437 ? 104.732 135.756 160.318 1.00 47.14  ? 463 PRO A CA  1 
ATOM   3297 C C   . PRO A 1 437 ? 105.186 137.207 160.253 1.00 49.95  ? 463 PRO A C   1 
ATOM   3298 O O   . PRO A 1 437 ? 105.218 137.839 159.195 1.00 53.94  ? 463 PRO A O   1 
ATOM   3299 C CB  . PRO A 1 437 ? 105.938 134.810 160.251 1.00 46.80  ? 463 PRO A CB  1 
ATOM   3300 C CG  . PRO A 1 437 ? 106.152 134.631 158.786 1.00 48.07  ? 463 PRO A CG  1 
ATOM   3301 C CD  . PRO A 1 437 ? 104.796 134.747 158.111 1.00 48.87  ? 463 PRO A CD  1 
ATOM   3302 N N   . GLN A 1 438 ? 105.541 137.724 161.426 1.00 42.84  ? 464 GLN A N   1 
ATOM   3303 C CA  . GLN A 1 438 ? 106.233 139.000 161.557 1.00 38.08  ? 464 GLN A CA  1 
ATOM   3304 C C   . GLN A 1 438 ? 107.590 138.722 162.183 1.00 45.68  ? 464 GLN A C   1 
ATOM   3305 O O   . GLN A 1 438 ? 107.662 138.148 163.275 1.00 58.86  ? 464 GLN A O   1 
ATOM   3306 C CB  . GLN A 1 438 ? 105.429 139.980 162.412 1.00 36.72  ? 464 GLN A CB  1 
ATOM   3307 C CG  . GLN A 1 438 ? 103.988 140.148 161.972 1.00 43.62  ? 464 GLN A CG  1 
ATOM   3308 C CD  . GLN A 1 438 ? 103.198 141.045 162.902 1.00 49.83  ? 464 GLN A CD  1 
ATOM   3309 O OE1 . GLN A 1 438 ? 103.734 141.579 163.872 1.00 52.16  ? 464 GLN A OE1 1 
ATOM   3310 N NE2 . GLN A 1 438 ? 101.913 141.213 162.612 1.00 48.14  ? 464 GLN A NE2 1 
ATOM   3311 N N   . ILE A 1 439 ? 108.658 139.124 161.500 1.00 35.13  ? 465 ILE A N   1 
ATOM   3312 C CA  . ILE A 1 439 ? 110.020 138.753 161.869 1.00 35.25  ? 465 ILE A CA  1 
ATOM   3313 C C   . ILE A 1 439 ? 110.776 139.996 162.314 1.00 43.84  ? 465 ILE A C   1 
ATOM   3314 O O   . ILE A 1 439 ? 110.811 141.003 161.596 1.00 51.11  ? 465 ILE A O   1 
ATOM   3315 C CB  . ILE A 1 439 ? 110.743 138.059 160.704 1.00 33.18  ? 465 ILE A CB  1 
ATOM   3316 C CG1 . ILE A 1 439 ? 109.920 136.872 160.209 1.00 35.78  ? 465 ILE A CG1 1 
ATOM   3317 C CG2 . ILE A 1 439 ? 112.120 137.596 161.137 1.00 42.20  ? 465 ILE A CG2 1 
ATOM   3318 C CD1 . ILE A 1 439 ? 110.554 136.137 159.064 1.00 40.95  ? 465 ILE A CD1 1 
ATOM   3319 N N   . TYR A 1 440 ? 111.380 139.922 163.498 1.00 39.48  ? 466 TYR A N   1 
ATOM   3320 C CA  . TYR A 1 440 ? 112.194 140.991 164.056 1.00 36.85  ? 466 TYR A CA  1 
ATOM   3321 C C   . TYR A 1 440 ? 113.612 140.487 164.284 1.00 40.44  ? 466 TYR A C   1 
ATOM   3322 O O   . TYR A 1 440 ? 113.815 139.343 164.708 1.00 52.45  ? 466 TYR A O   1 
ATOM   3323 C CB  . TYR A 1 440 ? 111.609 141.506 165.373 1.00 39.55  ? 466 TYR A CB  1 
ATOM   3324 C CG  . TYR A 1 440 ? 110.144 141.869 165.303 1.00 36.71  ? 466 TYR A CG  1 
ATOM   3325 C CD1 . TYR A 1 440 ? 109.726 143.033 164.676 1.00 42.72  ? 466 TYR A CD1 1 
ATOM   3326 C CD2 . TYR A 1 440 ? 109.182 141.055 165.878 1.00 35.68  ? 466 TYR A CD2 1 
ATOM   3327 C CE1 . TYR A 1 440 ? 108.389 143.368 164.617 1.00 42.10  ? 466 TYR A CE1 1 
ATOM   3328 C CE2 . TYR A 1 440 ? 107.845 141.383 165.824 1.00 33.81  ? 466 TYR A CE2 1 
ATOM   3329 C CZ  . TYR A 1 440 ? 107.455 142.539 165.193 1.00 33.55  ? 466 TYR A CZ  1 
ATOM   3330 O OH  . TYR A 1 440 ? 106.123 142.868 165.137 1.00 41.77  ? 466 TYR A OH  1 
ATOM   3331 N N   . PHE A 1 441 ? 114.588 141.347 164.007 1.00 35.54  ? 467 PHE A N   1 
ATOM   3332 C CA  . PHE A 1 441 ? 116.000 141.013 164.124 1.00 37.29  ? 467 PHE A CA  1 
ATOM   3333 C C   . PHE A 1 441 ? 116.657 141.883 165.185 1.00 44.18  ? 467 PHE A C   1 
ATOM   3334 O O   . PHE A 1 441 ? 116.325 143.063 165.328 1.00 48.69  ? 467 PHE A O   1 
ATOM   3335 C CB  . PHE A 1 441 ? 116.731 141.202 162.791 1.00 41.86  ? 467 PHE A CB  1 
ATOM   3336 C CG  . PHE A 1 441 ? 116.455 140.124 161.785 1.00 43.31  ? 467 PHE A CG  1 
ATOM   3337 C CD1 . PHE A 1 441 ? 115.340 140.185 160.971 1.00 41.39  ? 467 PHE A CD1 1 
ATOM   3338 C CD2 . PHE A 1 441 ? 117.319 139.055 161.646 1.00 45.31  ? 467 PHE A CD2 1 
ATOM   3339 C CE1 . PHE A 1 441 ? 115.089 139.196 160.044 1.00 40.97  ? 467 PHE A CE1 1 
ATOM   3340 C CE2 . PHE A 1 441 ? 117.071 138.065 160.719 1.00 43.81  ? 467 PHE A CE2 1 
ATOM   3341 C CZ  . PHE A 1 441 ? 115.954 138.137 159.919 1.00 41.62  ? 467 PHE A CZ  1 
ATOM   3342 N N   . ASP A 1 442 ? 117.592 141.291 165.928 1.00 43.71  ? 468 ASP A N   1 
ATOM   3343 C CA  . ASP A 1 442 ? 118.395 142.018 166.912 1.00 33.94  ? 468 ASP A CA  1 
ATOM   3344 C C   . ASP A 1 442 ? 119.831 141.528 166.757 1.00 34.80  ? 468 ASP A C   1 
ATOM   3345 O O   . ASP A 1 442 ? 120.156 140.410 167.167 1.00 48.65  ? 468 ASP A O   1 
ATOM   3346 C CB  . ASP A 1 442 ? 117.874 141.797 168.326 1.00 36.81  ? 468 ASP A CB  1 
ATOM   3347 C CG  . ASP A 1 442 ? 118.569 142.674 169.348 1.00 51.85  ? 468 ASP A CG  1 
ATOM   3348 O OD1 . ASP A 1 442 ? 119.360 143.552 168.945 1.00 57.18  ? 468 ASP A OD1 1 
ATOM   3349 O OD2 . ASP A 1 442 ? 118.323 142.487 170.558 1.00 54.90  ? 468 ASP A OD2 1 
ATOM   3350 N N   . ILE A 1 443 ? 120.679 142.358 166.156 1.00 30.24  ? 469 ILE A N   1 
ATOM   3351 C CA  . ILE A 1 443 ? 122.045 141.987 165.808 1.00 34.34  ? 469 ILE A CA  1 
ATOM   3352 C C   . ILE A 1 443 ? 123.004 142.970 166.463 1.00 47.78  ? 469 ILE A C   1 
ATOM   3353 O O   . ILE A 1 443 ? 122.831 144.188 166.342 1.00 53.12  ? 469 ILE A O   1 
ATOM   3354 C CB  . ILE A 1 443 ? 122.252 141.959 164.283 1.00 34.29  ? 469 ILE A CB  1 
ATOM   3355 C CG1 . ILE A 1 443 ? 121.292 140.963 163.634 1.00 39.32  ? 469 ILE A CG1 1 
ATOM   3356 C CG2 . ILE A 1 443 ? 123.690 141.610 163.946 1.00 43.84  ? 469 ILE A CG2 1 
ATOM   3357 C CD1 . ILE A 1 443 ? 121.393 140.913 162.130 1.00 48.10  ? 469 ILE A CD1 1 
ATOM   3358 N N   . TRP A 1 444 ? 124.011 142.440 167.154 1.00 38.00  ? 470 TRP A N   1 
ATOM   3359 C CA  . TRP A 1 444 ? 125.043 143.238 167.801 1.00 30.03  ? 470 TRP A CA  1 
ATOM   3360 C C   . TRP A 1 444 ? 126.364 143.037 167.073 1.00 40.54  ? 470 TRP A C   1 
ATOM   3361 O O   . TRP A 1 444 ? 126.768 141.898 166.818 1.00 52.68  ? 470 TRP A O   1 
ATOM   3362 C CB  . TRP A 1 444 ? 125.189 142.851 169.273 1.00 33.75  ? 470 TRP A CB  1 
ATOM   3363 C CG  . TRP A 1 444 ? 123.971 143.121 170.094 1.00 38.88  ? 470 TRP A CG  1 
ATOM   3364 C CD1 . TRP A 1 444 ? 122.849 142.354 170.170 1.00 38.80  ? 470 TRP A CD1 1 
ATOM   3365 C CD2 . TRP A 1 444 ? 123.757 144.232 170.969 1.00 40.18  ? 470 TRP A CD2 1 
ATOM   3366 N NE1 . TRP A 1 444 ? 121.946 142.921 171.032 1.00 39.50  ? 470 TRP A NE1 1 
ATOM   3367 C CE2 . TRP A 1 444 ? 122.481 144.076 171.537 1.00 36.04  ? 470 TRP A CE2 1 
ATOM   3368 C CE3 . TRP A 1 444 ? 124.521 145.346 171.324 1.00 43.99  ? 470 TRP A CE3 1 
ATOM   3369 C CZ2 . TRP A 1 444 ? 121.951 144.991 172.440 1.00 40.72  ? 470 TRP A CZ2 1 
ATOM   3370 C CZ3 . TRP A 1 444 ? 123.993 146.252 172.219 1.00 43.51  ? 470 TRP A CZ3 1 
ATOM   3371 C CH2 . TRP A 1 444 ? 122.721 146.069 172.768 1.00 41.22  ? 470 TRP A CH2 1 
ATOM   3372 N N   . VAL A 1 445 ? 127.035 144.138 166.742 1.00 40.08  ? 471 VAL A N   1 
ATOM   3373 C CA  . VAL A 1 445 ? 128.279 144.082 165.981 1.00 32.24  ? 471 VAL A CA  1 
ATOM   3374 C C   . VAL A 1 445 ? 129.117 145.307 166.321 1.00 39.85  ? 471 VAL A C   1 
ATOM   3375 O O   . VAL A 1 445 ? 128.587 146.404 166.517 1.00 49.81  ? 471 VAL A O   1 
ATOM   3376 C CB  . VAL A 1 445 ? 127.994 143.986 164.465 1.00 40.16  ? 471 VAL A CB  1 
ATOM   3377 C CG1 . VAL A 1 445 ? 127.054 145.097 164.025 1.00 43.67  ? 471 VAL A CG1 1 
ATOM   3378 C CG2 . VAL A 1 445 ? 129.285 144.016 163.660 1.00 46.81  ? 471 VAL A CG2 1 
ATOM   3379 N N   . SER A 1 446 ? 130.433 145.110 166.400 1.00 47.24  ? 472 SER A N   1 
ATOM   3380 C CA  . SER A 1 446 ? 131.384 146.185 166.638 1.00 50.01  ? 472 SER A CA  1 
ATOM   3381 C C   . SER A 1 446 ? 132.433 146.185 165.536 1.00 52.05  ? 472 SER A C   1 
ATOM   3382 O O   . SER A 1 446 ? 132.869 145.122 165.085 1.00 59.04  ? 472 SER A O   1 
ATOM   3383 C CB  . SER A 1 446 ? 132.065 146.042 168.001 1.00 51.64  ? 472 SER A CB  1 
ATOM   3384 O OG  . SER A 1 446 ? 132.929 144.921 168.023 1.00 50.85  ? 472 SER A OG  1 
ATOM   3385 N N   . ILE A 1 447 ? 132.836 147.378 165.109 1.00 52.76  ? 473 ILE A N   1 
ATOM   3386 C CA  . ILE A 1 447 ? 133.814 147.554 164.041 1.00 50.13  ? 473 ILE A CA  1 
ATOM   3387 C C   . ILE A 1 447 ? 135.092 148.112 164.650 1.00 55.45  ? 473 ILE A C   1 
ATOM   3388 O O   . ILE A 1 447 ? 135.073 149.178 165.277 1.00 63.04  ? 473 ILE A O   1 
ATOM   3389 C CB  . ILE A 1 447 ? 133.287 148.480 162.935 1.00 51.35  ? 473 ILE A CB  1 
ATOM   3390 C CG1 . ILE A 1 447 ? 132.125 147.826 162.191 1.00 55.54  ? 473 ILE A CG1 1 
ATOM   3391 C CG2 . ILE A 1 447 ? 134.400 148.841 161.968 1.00 51.58  ? 473 ILE A CG2 1 
ATOM   3392 C CD1 . ILE A 1 447 ? 131.614 148.647 161.030 1.00 55.49  ? 473 ILE A CD1 1 
ATOM   3393 N N   . ASN A 1 448 ? 136.201 147.398 164.453 1.00 53.33  ? 474 ASN A N   1 
ATOM   3394 C CA  . ASN A 1 448 ? 137.528 147.845 164.883 1.00 51.13  ? 474 ASN A CA  1 
ATOM   3395 C C   . ASN A 1 448 ? 137.571 148.136 166.383 1.00 55.87  ? 474 ASN A C   1 
ATOM   3396 O O   . ASN A 1 448 ? 138.020 149.198 166.821 1.00 60.84  ? 474 ASN A O   1 
ATOM   3397 C CB  . ASN A 1 448 ? 137.984 149.063 164.077 1.00 50.27  ? 474 ASN A CB  1 
ATOM   3398 C CG  . ASN A 1 448 ? 138.247 148.734 162.623 1.00 56.84  ? 474 ASN A CG  1 
ATOM   3399 O OD1 . ASN A 1 448 ? 138.644 147.618 162.289 1.00 56.74  ? 474 ASN A OD1 1 
ATOM   3400 N ND2 . ASN A 1 448 ? 138.030 149.707 161.747 1.00 60.22  ? 474 ASN A ND2 1 
ATOM   3401 N N   . ASP A 1 449 ? 137.093 147.174 167.173 1.00 57.53  ? 475 ASP A N   1 
ATOM   3402 C CA  . ASP A 1 449 ? 137.178 147.214 168.633 1.00 57.67  ? 475 ASP A CA  1 
ATOM   3403 C C   . ASP A 1 449 ? 136.479 148.453 169.201 1.00 55.93  ? 475 ASP A C   1 
ATOM   3404 O O   . ASP A 1 449 ? 137.078 149.287 169.881 1.00 55.85  ? 475 ASP A O   1 
ATOM   3405 C CB  . ASP A 1 449 ? 138.639 147.140 169.092 1.00 58.97  ? 475 ASP A CB  1 
ATOM   3406 C CG  . ASP A 1 449 ? 138.772 146.835 170.572 1.00 68.51  ? 475 ASP A CG  1 
ATOM   3407 O OD1 . ASP A 1 449 ? 137.742 146.566 171.225 1.00 67.33  ? 475 ASP A OD1 1 
ATOM   3408 O OD2 . ASP A 1 449 ? 139.912 146.864 171.081 1.00 70.62  ? 475 ASP A OD2 1 
ATOM   3409 N N   . ARG A 1 450 ? 135.189 148.556 168.906 1.00 48.90  ? 476 ARG A N   1 
ATOM   3410 C CA  . ARG A 1 450 ? 134.320 149.585 169.456 1.00 49.60  ? 476 ARG A CA  1 
ATOM   3411 C C   . ARG A 1 450 ? 133.286 148.944 170.376 1.00 51.73  ? 476 ARG A C   1 
ATOM   3412 O O   . ARG A 1 450 ? 133.304 147.737 170.631 1.00 53.54  ? 476 ARG A O   1 
ATOM   3413 C CB  . ARG A 1 450 ? 133.632 150.376 168.342 1.00 47.31  ? 476 ARG A CB  1 
ATOM   3414 C CG  . ARG A 1 450 ? 134.548 151.255 167.519 1.00 45.92  ? 476 ARG A CG  1 
ATOM   3415 C CD  . ARG A 1 450 ? 133.766 151.932 166.407 1.00 46.61  ? 476 ARG A CD  1 
ATOM   3416 N NE  . ARG A 1 450 ? 134.571 152.127 165.209 1.00 49.29  ? 476 ARG A NE  1 
ATOM   3417 C CZ  . ARG A 1 450 ? 135.142 153.272 164.866 1.00 52.58  ? 476 ARG A CZ  1 
ATOM   3418 N NH1 . ARG A 1 450 ? 135.007 154.360 165.606 1.00 57.12  ? 476 ARG A NH1 1 
ATOM   3419 N NH2 . ARG A 1 450 ? 135.865 153.328 163.751 1.00 50.68  ? 476 ARG A NH2 1 
ATOM   3420 N N   . PHE A 1 451 ? 132.377 149.773 170.878 1.00 48.43  ? 477 PHE A N   1 
ATOM   3421 C CA  . PHE A 1 451 ? 131.280 149.276 171.691 1.00 45.35  ? 477 PHE A CA  1 
ATOM   3422 C C   . PHE A 1 451 ? 130.338 148.418 170.855 1.00 50.20  ? 477 PHE A C   1 
ATOM   3423 O O   . PHE A 1 451 ? 130.110 148.677 169.670 1.00 52.18  ? 477 PHE A O   1 
ATOM   3424 C CB  . PHE A 1 451 ? 130.505 150.437 172.312 1.00 47.76  ? 477 PHE A CB  1 
ATOM   3425 C CG  . PHE A 1 451 ? 131.200 151.081 173.472 1.00 46.94  ? 477 PHE A CG  1 
ATOM   3426 C CD1 . PHE A 1 451 ? 132.098 152.110 173.272 1.00 50.01  ? 477 PHE A CD1 1 
ATOM   3427 C CD2 . PHE A 1 451 ? 130.950 150.659 174.765 1.00 50.97  ? 477 PHE A CD2 1 
ATOM   3428 C CE1 . PHE A 1 451 ? 132.735 152.705 174.340 1.00 50.24  ? 477 PHE A CE1 1 
ATOM   3429 C CE2 . PHE A 1 451 ? 131.586 151.252 175.835 1.00 50.20  ? 477 PHE A CE2 1 
ATOM   3430 C CZ  . PHE A 1 451 ? 132.478 152.276 175.622 1.00 46.26  ? 477 PHE A CZ  1 
ATOM   3431 N N   . GLN A 1 452 ? 129.791 147.384 171.485 1.00 48.63  ? 478 GLN A N   1 
ATOM   3432 C CA  . GLN A 1 452 ? 128.810 146.527 170.832 1.00 44.36  ? 478 GLN A CA  1 
ATOM   3433 C C   . GLN A 1 452 ? 127.467 147.245 170.802 1.00 45.78  ? 478 GLN A C   1 
ATOM   3434 O O   . GLN A 1 452 ? 126.889 147.535 171.854 1.00 49.24  ? 478 GLN A O   1 
ATOM   3435 C CB  . GLN A 1 452 ? 128.691 145.193 171.564 1.00 46.22  ? 478 GLN A CB  1 
ATOM   3436 C CG  . GLN A 1 452 ? 129.959 144.362 171.576 1.00 42.58  ? 478 GLN A CG  1 
ATOM   3437 C CD  . GLN A 1 452 ? 130.143 143.562 170.306 1.00 45.59  ? 478 GLN A CD  1 
ATOM   3438 O OE1 . GLN A 1 452 ? 129.224 143.443 169.497 1.00 49.00  ? 478 GLN A OE1 1 
ATOM   3439 N NE2 . GLN A 1 452 ? 131.335 143.009 170.121 1.00 46.72  ? 478 GLN A NE2 1 
ATOM   3440 N N   . GLN A 1 453 ? 126.972 147.534 169.602 1.00 43.91  ? 479 GLN A N   1 
ATOM   3441 C CA  . GLN A 1 453 ? 125.713 148.243 169.443 1.00 43.80  ? 479 GLN A CA  1 
ATOM   3442 C C   . GLN A 1 453 ? 124.879 147.565 168.368 1.00 42.54  ? 479 GLN A C   1 
ATOM   3443 O O   . GLN A 1 453 ? 125.390 146.815 167.534 1.00 47.61  ? 479 GLN A O   1 
ATOM   3444 C CB  . GLN A 1 453 ? 125.931 149.716 169.079 1.00 46.08  ? 479 GLN A CB  1 
ATOM   3445 C CG  . GLN A 1 453 ? 126.742 149.921 167.815 1.00 42.87  ? 479 GLN A CG  1 
ATOM   3446 C CD  . GLN A 1 453 ? 126.555 151.298 167.223 1.00 43.90  ? 479 GLN A CD  1 
ATOM   3447 O OE1 . GLN A 1 453 ? 127.470 151.858 166.622 1.00 49.76  ? 479 GLN A OE1 1 
ATOM   3448 N NE2 . GLN A 1 453 ? 125.359 151.850 167.380 1.00 46.77  ? 479 GLN A NE2 1 
ATOM   3449 N N   . ARG A 1 454 ? 123.580 147.840 168.403 1.00 35.96  ? 480 ARG A N   1 
ATOM   3450 C CA  . ARG A 1 454 ? 122.676 147.314 167.395 1.00 36.07  ? 480 ARG A CA  1 
ATOM   3451 C C   . ARG A 1 454 ? 122.941 147.967 166.044 1.00 47.72  ? 480 ARG A C   1 
ATOM   3452 O O   . ARG A 1 454 ? 123.351 149.127 165.956 1.00 50.20  ? 480 ARG A O   1 
ATOM   3453 C CB  . ARG A 1 454 ? 121.223 147.546 167.804 1.00 34.78  ? 480 ARG A CB  1 
ATOM   3454 C CG  . ARG A 1 454 ? 120.764 146.719 168.985 1.00 35.05  ? 480 ARG A CG  1 
ATOM   3455 C CD  . ARG A 1 454 ? 119.312 147.007 169.307 1.00 40.70  ? 480 ARG A CD  1 
ATOM   3456 N NE  . ARG A 1 454 ? 118.769 146.077 170.287 1.00 40.36  ? 480 ARG A NE  1 
ATOM   3457 C CZ  . ARG A 1 454 ? 118.785 146.275 171.597 1.00 44.64  ? 480 ARG A CZ  1 
ATOM   3458 N NH1 . ARG A 1 454 ? 119.320 147.363 172.125 1.00 45.97  ? 480 ARG A NH1 1 
ATOM   3459 N NH2 . ARG A 1 454 ? 118.252 145.357 172.398 1.00 43.16  ? 480 ARG A NH2 1 
ATOM   3460 N N   . ILE A 1 455 ? 122.699 147.204 164.983 1.00 44.57  ? 481 ILE A N   1 
ATOM   3461 C CA  . ILE A 1 455 ? 122.834 147.688 163.620 1.00 40.55  ? 481 ILE A CA  1 
ATOM   3462 C C   . ILE A 1 455 ? 121.475 147.947 162.979 1.00 44.17  ? 481 ILE A C   1 
ATOM   3463 O O   . ILE A 1 455 ? 121.318 148.905 162.219 1.00 51.58  ? 481 ILE A O   1 
ATOM   3464 C CB  . ILE A 1 455 ? 123.675 146.705 162.775 1.00 38.57  ? 481 ILE A CB  1 
ATOM   3465 C CG1 . ILE A 1 455 ? 123.755 147.162 161.319 1.00 41.39  ? 481 ILE A CG1 1 
ATOM   3466 C CG2 . ILE A 1 455 ? 123.126 145.294 162.882 1.00 44.27  ? 481 ILE A CG2 1 
ATOM   3467 C CD1 . ILE A 1 455 ? 124.641 146.293 160.463 1.00 49.00  ? 481 ILE A CD1 1 
ATOM   3468 N N   . PHE A 1 456 ? 120.480 147.121 163.287 1.00 37.02  ? 482 PHE A N   1 
ATOM   3469 C CA  . PHE A 1 456 ? 119.125 147.293 162.787 1.00 34.21  ? 482 PHE A CA  1 
ATOM   3470 C C   . PHE A 1 456 ? 118.164 147.545 163.941 1.00 43.27  ? 482 PHE A C   1 
ATOM   3471 O O   . PHE A 1 456 ? 118.385 147.092 165.067 1.00 54.36  ? 482 PHE A O   1 
ATOM   3472 C CB  . PHE A 1 456 ? 118.664 146.066 161.995 1.00 35.78  ? 482 PHE A CB  1 
ATOM   3473 C CG  . PHE A 1 456 ? 119.553 145.722 160.840 1.00 37.36  ? 482 PHE A CG  1 
ATOM   3474 C CD1 . PHE A 1 456 ? 119.588 146.526 159.716 1.00 40.07  ? 482 PHE A CD1 1 
ATOM   3475 C CD2 . PHE A 1 456 ? 120.348 144.593 160.873 1.00 44.44  ? 482 PHE A CD2 1 
ATOM   3476 C CE1 . PHE A 1 456 ? 120.406 146.212 158.653 1.00 42.50  ? 482 PHE A CE1 1 
ATOM   3477 C CE2 . PHE A 1 456 ? 121.166 144.275 159.814 1.00 45.29  ? 482 PHE A CE2 1 
ATOM   3478 C CZ  . PHE A 1 456 ? 121.195 145.085 158.703 1.00 41.50  ? 482 PHE A CZ  1 
ATOM   3479 N N   . ASP A 1 457 ? 117.097 148.275 163.648 1.00 38.46  ? 483 ASP A N   1 
ATOM   3480 C CA  . ASP A 1 457 ? 116.078 148.574 164.646 1.00 38.01  ? 483 ASP A CA  1 
ATOM   3481 C C   . ASP A 1 457 ? 115.358 147.291 165.040 1.00 43.24  ? 483 ASP A C   1 
ATOM   3482 O O   . ASP A 1 457 ? 114.834 146.592 164.162 1.00 50.07  ? 483 ASP A O   1 
ATOM   3483 C CB  . ASP A 1 457 ? 115.091 149.597 164.087 1.00 38.48  ? 483 ASP A CB  1 
ATOM   3484 C CG  . ASP A 1 457 ? 114.247 150.257 165.162 1.00 45.05  ? 483 ASP A CG  1 
ATOM   3485 O OD1 . ASP A 1 457 ? 113.895 149.591 166.156 1.00 51.16  ? 483 ASP A OD1 1 
ATOM   3486 O OD2 . ASP A 1 457 ? 113.928 151.454 165.008 1.00 47.24  ? 483 ASP A OD2 1 
ATOM   3487 N N   . PRO A 1 458 ? 115.305 146.939 166.324 1.00 37.79  ? 484 PRO A N   1 
ATOM   3488 C CA  . PRO A 1 458 ? 114.653 145.692 166.737 1.00 39.32  ? 484 PRO A CA  1 
ATOM   3489 C C   . PRO A 1 458 ? 113.147 145.788 166.919 1.00 44.56  ? 484 PRO A C   1 
ATOM   3490 O O   . PRO A 1 458 ? 112.551 144.852 167.458 1.00 46.45  ? 484 PRO A O   1 
ATOM   3491 C CB  . PRO A 1 458 ? 115.340 145.390 168.076 1.00 41.39  ? 484 PRO A CB  1 
ATOM   3492 C CG  . PRO A 1 458 ? 115.665 146.728 168.621 1.00 43.52  ? 484 PRO A CG  1 
ATOM   3493 C CD  . PRO A 1 458 ? 116.026 147.580 167.437 1.00 45.29  ? 484 PRO A CD  1 
ATOM   3494 N N   . ARG A 1 459 ? 112.515 146.880 166.491 1.00 47.77  ? 485 ARG A N   1 
ATOM   3495 C CA  . ARG A 1 459 ? 111.072 147.039 166.606 1.00 43.41  ? 485 ARG A CA  1 
ATOM   3496 C C   . ARG A 1 459 ? 110.384 147.114 165.250 1.00 48.67  ? 485 ARG A C   1 
ATOM   3497 O O   . ARG A 1 459 ? 109.205 147.480 165.186 1.00 52.56  ? 485 ARG A O   1 
ATOM   3498 C CB  . ARG A 1 459 ? 110.743 148.293 167.419 1.00 41.19  ? 485 ARG A CB  1 
ATOM   3499 C CG  . ARG A 1 459 ? 111.478 148.389 168.741 1.00 46.04  ? 485 ARG A CG  1 
ATOM   3500 C CD  . ARG A 1 459 ? 111.512 149.823 169.238 1.00 46.60  ? 485 ARG A CD  1 
ATOM   3501 N NE  . ARG A 1 459 ? 112.230 150.695 168.316 1.00 47.90  ? 485 ARG A NE  1 
ATOM   3502 C CZ  . ARG A 1 459 ? 112.430 151.991 168.511 1.00 49.30  ? 485 ARG A CZ  1 
ATOM   3503 N NH1 . ARG A 1 459 ? 111.974 152.606 169.588 1.00 47.59  ? 485 ARG A NH1 1 
ATOM   3504 N NH2 . ARG A 1 459 ? 113.105 152.686 167.601 1.00 49.51  ? 485 ARG A NH2 1 
ATOM   3505 N N   . VAL A 1 460 ? 111.080 146.775 164.168 1.00 43.26  ? 486 VAL A N   1 
ATOM   3506 C CA  . VAL A 1 460 ? 110.581 146.958 162.811 1.00 37.18  ? 486 VAL A CA  1 
ATOM   3507 C C   . VAL A 1 460 ? 110.437 145.593 162.156 1.00 43.18  ? 486 VAL A C   1 
ATOM   3508 O O   . VAL A 1 460 ? 111.384 144.799 162.147 1.00 49.73  ? 486 VAL A O   1 
ATOM   3509 C CB  . VAL A 1 460 ? 111.510 147.863 161.982 1.00 39.73  ? 486 VAL A CB  1 
ATOM   3510 C CG1 . VAL A 1 460 ? 110.983 148.009 160.566 1.00 44.65  ? 486 VAL A CG1 1 
ATOM   3511 C CG2 . VAL A 1 460 ? 111.651 149.223 162.641 1.00 40.75  ? 486 VAL A CG2 1 
ATOM   3512 N N   . ASP A 1 461 ? 109.251 145.322 161.616 1.00 43.49  ? 487 ASP A N   1 
ATOM   3513 C CA  . ASP A 1 461 ? 109.002 144.092 160.873 1.00 36.99  ? 487 ASP A CA  1 
ATOM   3514 C C   . ASP A 1 461 ? 109.691 144.176 159.517 1.00 43.88  ? 487 ASP A C   1 
ATOM   3515 O O   . ASP A 1 461 ? 109.275 144.950 158.649 1.00 52.65  ? 487 ASP A O   1 
ATOM   3516 C CB  . ASP A 1 461 ? 107.502 143.870 160.714 1.00 38.58  ? 487 ASP A CB  1 
ATOM   3517 C CG  . ASP A 1 461 ? 107.169 142.501 160.164 1.00 48.92  ? 487 ASP A CG  1 
ATOM   3518 O OD1 . ASP A 1 461 ? 108.094 141.677 160.009 1.00 53.12  ? 487 ASP A OD1 1 
ATOM   3519 O OD2 . ASP A 1 461 ? 105.979 142.246 159.886 1.00 52.55  ? 487 ASP A OD2 1 
ATOM   3520 N N   . ILE A 1 462 ? 110.749 143.384 159.331 1.00 36.45  ? 488 ILE A N   1 
ATOM   3521 C CA  . ILE A 1 462 ? 111.501 143.422 158.083 1.00 33.30  ? 488 ILE A CA  1 
ATOM   3522 C C   . ILE A 1 462 ? 110.703 142.835 156.925 1.00 44.02  ? 488 ILE A C   1 
ATOM   3523 O O   . ILE A 1 462 ? 110.962 143.173 155.764 1.00 49.11  ? 488 ILE A O   1 
ATOM   3524 C CB  . ILE A 1 462 ? 112.842 142.687 158.255 1.00 34.06  ? 488 ILE A CB  1 
ATOM   3525 C CG1 . ILE A 1 462 ? 113.525 143.128 159.549 1.00 37.76  ? 488 ILE A CG1 1 
ATOM   3526 C CG2 . ILE A 1 462 ? 113.761 142.954 157.076 1.00 41.40  ? 488 ILE A CG2 1 
ATOM   3527 C CD1 . ILE A 1 462 ? 113.875 144.597 159.587 1.00 43.55  ? 488 ILE A CD1 1 
ATOM   3528 N N   . VAL A 1 463 ? 109.727 141.971 157.209 1.00 41.29  ? 489 VAL A N   1 
ATOM   3529 C CA  . VAL A 1 463 ? 108.907 141.400 156.144 1.00 35.28  ? 489 VAL A CA  1 
ATOM   3530 C C   . VAL A 1 463 ? 108.088 142.486 155.459 1.00 43.52  ? 489 VAL A C   1 
ATOM   3531 O O   . VAL A 1 463 ? 107.930 142.483 154.233 1.00 49.31  ? 489 VAL A O   1 
ATOM   3532 C CB  . VAL A 1 463 ? 108.010 140.282 156.704 1.00 33.50  ? 489 VAL A CB  1 
ATOM   3533 C CG1 . VAL A 1 463 ? 107.232 139.614 155.587 1.00 36.88  ? 489 VAL A CG1 1 
ATOM   3534 C CG2 . VAL A 1 463 ? 108.845 139.263 157.458 1.00 41.29  ? 489 VAL A CG2 1 
ATOM   3535 N N   . GLN A 1 464 ? 107.558 143.431 156.232 1.00 47.80  ? 490 GLN A N   1 
ATOM   3536 C CA  . GLN A 1 464 ? 106.748 144.519 155.703 1.00 40.34  ? 490 GLN A CA  1 
ATOM   3537 C C   . GLN A 1 464 ? 107.505 145.838 155.625 1.00 45.16  ? 490 GLN A C   1 
ATOM   3538 O O   . GLN A 1 464 ? 106.886 146.881 155.393 1.00 53.47  ? 490 GLN A O   1 
ATOM   3539 C CB  . GLN A 1 464 ? 105.486 144.692 156.550 1.00 43.04  ? 490 GLN A CB  1 
ATOM   3540 C CG  . GLN A 1 464 ? 104.614 143.450 156.632 1.00 47.32  ? 490 GLN A CG  1 
ATOM   3541 C CD  . GLN A 1 464 ? 103.955 143.108 155.312 1.00 50.53  ? 490 GLN A CD  1 
ATOM   3542 O OE1 . GLN A 1 464 ? 103.852 143.950 154.420 1.00 51.90  ? 490 GLN A OE1 1 
ATOM   3543 N NE2 . GLN A 1 464 ? 103.503 141.867 155.181 1.00 49.01  ? 490 GLN A NE2 1 
ATOM   3544 N N   . ALA A 1 465 ? 108.822 145.820 155.809 1.00 42.34  ? 491 ALA A N   1 
ATOM   3545 C CA  . ALA A 1 465 ? 109.606 147.043 155.794 1.00 38.31  ? 491 ALA A CA  1 
ATOM   3546 C C   . ALA A 1 465 ? 109.769 147.563 154.368 1.00 44.49  ? 491 ALA A C   1 
ATOM   3547 O O   . ALA A 1 465 ? 109.495 146.869 153.385 1.00 51.00  ? 491 ALA A O   1 
ATOM   3548 C CB  . ALA A 1 465 ? 110.972 146.812 156.438 1.00 40.35  ? 491 ALA A CB  1 
ATOM   3549 N N   . ALA A 1 466 ? 110.221 148.809 154.263 1.00 37.94  ? 492 ALA A N   1 
ATOM   3550 C CA  . ALA A 1 466 ? 110.397 149.486 152.986 1.00 40.83  ? 492 ALA A CA  1 
ATOM   3551 C C   . ALA A 1 466 ? 111.877 149.564 152.645 1.00 41.68  ? 492 ALA A C   1 
ATOM   3552 O O   . ALA A 1 466 ? 112.680 150.034 153.457 1.00 43.45  ? 492 ALA A O   1 
ATOM   3553 C CB  . ALA A 1 466 ? 109.788 150.888 153.025 1.00 38.21  ? 492 ALA A CB  1 
ATOM   3554 N N   . TRP A 1 467 ? 112.234 149.105 151.447 1.00 37.49  ? 493 TRP A N   1 
ATOM   3555 C CA  . TRP A 1 467 ? 113.616 149.146 150.990 1.00 35.02  ? 493 TRP A CA  1 
ATOM   3556 C C   . TRP A 1 467 ? 113.644 149.361 149.485 1.00 43.02  ? 493 TRP A C   1 
ATOM   3557 O O   . TRP A 1 467 ? 112.975 148.638 148.741 1.00 49.70  ? 493 TRP A O   1 
ATOM   3558 C CB  . TRP A 1 467 ? 114.358 147.857 151.353 1.00 32.86  ? 493 TRP A CB  1 
ATOM   3559 C CG  . TRP A 1 467 ? 115.737 147.776 150.781 1.00 33.73  ? 493 TRP A CG  1 
ATOM   3560 C CD1 . TRP A 1 467 ? 116.878 148.277 151.326 1.00 40.74  ? 493 TRP A CD1 1 
ATOM   3561 C CD2 . TRP A 1 467 ? 116.121 147.149 149.552 1.00 36.65  ? 493 TRP A CD2 1 
ATOM   3562 N NE1 . TRP A 1 467 ? 117.950 148.007 150.513 1.00 40.63  ? 493 TRP A NE1 1 
ATOM   3563 C CE2 . TRP A 1 467 ? 117.512 147.315 149.417 1.00 33.28  ? 493 TRP A CE2 1 
ATOM   3564 C CE3 . TRP A 1 467 ? 115.424 146.467 148.551 1.00 43.40  ? 493 TRP A CE3 1 
ATOM   3565 C CZ2 . TRP A 1 467 ? 118.217 146.826 148.323 1.00 40.80  ? 493 TRP A CZ2 1 
ATOM   3566 C CZ3 . TRP A 1 467 ? 116.127 145.981 147.468 1.00 43.15  ? 493 TRP A CZ3 1 
ATOM   3567 C CH2 . TRP A 1 467 ? 117.509 146.162 147.362 1.00 45.24  ? 493 TRP A CH2 1 
ATOM   3568 N N   . SER A 1 468 ? 114.416 150.353 149.045 1.00 41.30  ? 494 SER A N   1 
ATOM   3569 C CA  . SER A 1 468 ? 114.632 150.624 147.635 1.00 32.92  ? 494 SER A CA  1 
ATOM   3570 C C   . SER A 1 468 ? 116.112 150.878 147.390 1.00 42.62  ? 494 SER A C   1 
ATOM   3571 O O   . SER A 1 468 ? 116.795 151.450 148.249 1.00 48.24  ? 494 SER A O   1 
ATOM   3572 C CB  . SER A 1 468 ? 113.809 151.832 147.168 1.00 41.96  ? 494 SER A CB  1 
ATOM   3573 O OG  . SER A 1 468 ? 114.103 152.976 147.947 1.00 51.34  ? 494 SER A OG  1 
ATOM   3574 N N   . PRO A 1 469 ? 116.639 150.460 146.236 1.00 43.15  ? 495 PRO A N   1 
ATOM   3575 C CA  . PRO A 1 469 ? 118.089 150.572 146.010 1.00 34.27  ? 495 PRO A CA  1 
ATOM   3576 C C   . PRO A 1 469 ? 118.606 151.998 145.961 1.00 40.03  ? 495 PRO A C   1 
ATOM   3577 O O   . PRO A 1 469 ? 119.799 152.209 146.208 1.00 44.53  ? 495 PRO A O   1 
ATOM   3578 C CB  . PRO A 1 469 ? 118.291 149.867 144.661 1.00 32.39  ? 495 PRO A CB  1 
ATOM   3579 C CG  . PRO A 1 469 ? 117.083 149.012 144.485 1.00 39.22  ? 495 PRO A CG  1 
ATOM   3580 C CD  . PRO A 1 469 ? 115.962 149.756 145.137 1.00 45.49  ? 495 PRO A CD  1 
ATOM   3581 N N   . PHE A 1 470 ? 117.763 152.982 145.649 1.00 49.93  ? 496 PHE A N   1 
ATOM   3582 C CA  . PHE A 1 470 ? 118.214 154.355 145.463 1.00 45.23  ? 496 PHE A CA  1 
ATOM   3583 C C   . PHE A 1 470 ? 117.760 155.292 146.575 1.00 50.73  ? 496 PHE A C   1 
ATOM   3584 O O   . PHE A 1 470 ? 117.868 156.513 146.422 1.00 57.95  ? 496 PHE A O   1 
ATOM   3585 C CB  . PHE A 1 470 ? 117.741 154.882 144.107 1.00 48.02  ? 496 PHE A CB  1 
ATOM   3586 C CG  . PHE A 1 470 ? 118.196 154.048 142.947 1.00 52.24  ? 496 PHE A CG  1 
ATOM   3587 C CD1 . PHE A 1 470 ? 119.540 153.946 142.636 1.00 52.53  ? 496 PHE A CD1 1 
ATOM   3588 C CD2 . PHE A 1 470 ? 117.280 153.368 142.165 1.00 52.05  ? 496 PHE A CD2 1 
ATOM   3589 C CE1 . PHE A 1 470 ? 119.964 153.178 141.572 1.00 53.46  ? 496 PHE A CE1 1 
ATOM   3590 C CE2 . PHE A 1 470 ? 117.698 152.600 141.097 1.00 54.18  ? 496 PHE A CE2 1 
ATOM   3591 C CZ  . PHE A 1 470 ? 119.042 152.505 140.801 1.00 52.83  ? 496 PHE A CZ  1 
ATOM   3592 N N   . GLN A 1 471 ? 117.257 154.761 147.685 1.00 46.84  ? 497 GLN A N   1 
ATOM   3593 C CA  . GLN A 1 471 ? 116.880 155.575 148.830 1.00 38.96  ? 497 GLN A CA  1 
ATOM   3594 C C   . GLN A 1 471 ? 117.470 154.978 150.098 1.00 43.32  ? 497 GLN A C   1 
ATOM   3595 O O   . GLN A 1 471 ? 117.667 153.765 150.202 1.00 53.87  ? 497 GLN A O   1 
ATOM   3596 C CB  . GLN A 1 471 ? 115.360 155.694 148.970 1.00 41.24  ? 497 GLN A CB  1 
ATOM   3597 C CG  . GLN A 1 471 ? 114.682 156.367 147.793 1.00 49.21  ? 497 GLN A CG  1 
ATOM   3598 C CD  . GLN A 1 471 ? 113.185 156.479 147.976 1.00 55.27  ? 497 GLN A CD  1 
ATOM   3599 O OE1 . GLN A 1 471 ? 112.642 156.077 149.004 1.00 58.06  ? 497 GLN A OE1 1 
ATOM   3600 N NE2 . GLN A 1 471 ? 112.506 157.030 146.976 1.00 55.83  ? 497 GLN A NE2 1 
ATOM   3601 N N   . ARG A 1 472 ? 117.751 155.849 151.060 1.00 44.79  ? 498 ARG A N   1 
ATOM   3602 C CA  . ARG A 1 472 ? 118.362 155.421 152.309 1.00 49.20  ? 498 ARG A CA  1 
ATOM   3603 C C   . ARG A 1 472 ? 117.364 154.642 153.156 1.00 55.74  ? 498 ARG A C   1 
ATOM   3604 O O   . ARG A 1 472 ? 116.186 154.999 153.246 1.00 60.21  ? 498 ARG A O   1 
ATOM   3605 C CB  . ARG A 1 472 ? 118.874 156.634 153.081 1.00 48.85  ? 498 ARG A CB  1 
ATOM   3606 C CG  . ARG A 1 472 ? 119.914 156.313 154.134 1.00 51.14  ? 498 ARG A CG  1 
ATOM   3607 C CD  . ARG A 1 472 ? 120.268 157.554 154.928 1.00 56.37  ? 498 ARG A CD  1 
ATOM   3608 N NE  . ARG A 1 472 ? 120.523 158.696 154.058 1.00 61.18  ? 498 ARG A NE  1 
ATOM   3609 C CZ  . ARG A 1 472 ? 120.799 159.919 154.488 1.00 62.30  ? 498 ARG A CZ  1 
ATOM   3610 N NH1 . ARG A 1 472 ? 120.869 160.198 155.779 1.00 58.94  ? 498 ARG A NH1 1 
ATOM   3611 N NH2 . ARG A 1 472 ? 121.011 160.886 153.600 1.00 59.66  ? 498 ARG A NH2 1 
ATOM   3612 N N   . THR A 1 473 ? 117.843 153.568 153.779 1.00 45.51  ? 499 THR A N   1 
ATOM   3613 C CA  . THR A 1 473 ? 116.996 152.767 154.650 1.00 36.91  ? 499 THR A CA  1 
ATOM   3614 C C   . THR A 1 473 ? 116.721 153.506 155.952 1.00 40.09  ? 499 THR A C   1 
ATOM   3615 O O   . THR A 1 473 ? 117.612 154.135 156.530 1.00 46.42  ? 499 THR A O   1 
ATOM   3616 C CB  . THR A 1 473 ? 117.658 151.423 154.940 1.00 40.28  ? 499 THR A CB  1 
ATOM   3617 O OG1 . THR A 1 473 ? 118.972 151.644 155.466 1.00 48.26  ? 499 THR A OG1 1 
ATOM   3618 C CG2 . THR A 1 473 ? 117.768 150.607 153.671 1.00 42.02  ? 499 THR A CG2 1 
ATOM   3619 N N   . SER A 1 474 ? 115.477 153.429 156.416 1.00 41.69  ? 500 SER A N   1 
ATOM   3620 C CA  . SER A 1 474 ? 115.052 154.142 157.612 1.00 39.15  ? 500 SER A CA  1 
ATOM   3621 C C   . SER A 1 474 ? 115.153 153.307 158.882 1.00 50.39  ? 500 SER A C   1 
ATOM   3622 O O   . SER A 1 474 ? 114.844 153.817 159.963 1.00 52.10  ? 500 SER A O   1 
ATOM   3623 C CB  . SER A 1 474 ? 113.612 154.636 157.445 1.00 42.16  ? 500 SER A CB  1 
ATOM   3624 O OG  . SER A 1 474 ? 112.720 153.551 157.264 1.00 44.25  ? 500 SER A OG  1 
ATOM   3625 N N   . TRP A 1 475 ? 115.574 152.048 158.786 1.00 47.34  ? 501 TRP A N   1 
ATOM   3626 C CA  . TRP A 1 475 ? 115.693 151.170 159.942 1.00 36.87  ? 501 TRP A CA  1 
ATOM   3627 C C   . TRP A 1 475 ? 117.118 150.659 160.110 1.00 38.14  ? 501 TRP A C   1 
ATOM   3628 O O   . TRP A 1 475 ? 117.346 149.493 160.434 1.00 51.00  ? 501 TRP A O   1 
ATOM   3629 C CB  . TRP A 1 475 ? 114.708 150.006 159.852 1.00 30.66  ? 501 TRP A CB  1 
ATOM   3630 C CG  . TRP A 1 475 ? 114.503 149.464 158.475 1.00 32.01  ? 501 TRP A CG  1 
ATOM   3631 C CD1 . TRP A 1 475 ? 113.613 149.911 157.547 1.00 34.84  ? 501 TRP A CD1 1 
ATOM   3632 C CD2 . TRP A 1 475 ? 115.184 148.356 157.876 1.00 38.14  ? 501 TRP A CD2 1 
ATOM   3633 N NE1 . TRP A 1 475 ? 113.705 149.159 156.403 1.00 43.10  ? 501 TRP A NE1 1 
ATOM   3634 C CE2 . TRP A 1 475 ? 114.662 148.197 156.580 1.00 38.55  ? 501 TRP A CE2 1 
ATOM   3635 C CE3 . TRP A 1 475 ? 116.190 147.488 158.309 1.00 40.59  ? 501 TRP A CE3 1 
ATOM   3636 C CZ2 . TRP A 1 475 ? 115.110 147.207 155.714 1.00 37.24  ? 501 TRP A CZ2 1 
ATOM   3637 C CZ3 . TRP A 1 475 ? 116.632 146.506 157.447 1.00 38.05  ? 501 TRP A CZ3 1 
ATOM   3638 C CH2 . TRP A 1 475 ? 116.093 146.374 156.165 1.00 37.43  ? 501 TRP A CH2 1 
ATOM   3639 N N   . VAL A 1 476 ? 118.096 151.533 159.892 1.00 35.01  ? 502 VAL A N   1 
ATOM   3640 C CA  . VAL A 1 476 ? 119.499 151.241 160.165 1.00 37.46  ? 502 VAL A CA  1 
ATOM   3641 C C   . VAL A 1 476 ? 119.981 152.237 161.207 1.00 42.36  ? 502 VAL A C   1 
ATOM   3642 O O   . VAL A 1 476 ? 119.936 153.453 160.980 1.00 46.83  ? 502 VAL A O   1 
ATOM   3643 C CB  . VAL A 1 476 ? 120.361 151.308 158.895 1.00 34.96  ? 502 VAL A CB  1 
ATOM   3644 C CG1 . VAL A 1 476 ? 121.832 151.388 159.259 1.00 41.06  ? 502 VAL A CG1 1 
ATOM   3645 C CG2 . VAL A 1 476 ? 120.105 150.096 158.025 1.00 35.21  ? 502 VAL A CG2 1 
ATOM   3646 N N   . GLN A 1 477 ? 120.436 151.726 162.345 1.00 42.44  ? 503 GLN A N   1 
ATOM   3647 C CA  . GLN A 1 477 ? 120.881 152.598 163.417 1.00 44.91  ? 503 GLN A CA  1 
ATOM   3648 C C   . GLN A 1 477 ? 122.202 153.265 163.041 1.00 44.67  ? 503 GLN A C   1 
ATOM   3649 O O   . GLN A 1 477 ? 123.087 152.618 162.473 1.00 47.31  ? 503 GLN A O   1 
ATOM   3650 C CB  . GLN A 1 477 ? 121.041 151.811 164.716 1.00 46.24  ? 503 GLN A CB  1 
ATOM   3651 C CG  . GLN A 1 477 ? 119.745 151.230 165.253 1.00 44.77  ? 503 GLN A CG  1 
ATOM   3652 C CD  . GLN A 1 477 ? 118.758 152.297 165.681 1.00 52.59  ? 503 GLN A CD  1 
ATOM   3653 O OE1 . GLN A 1 477 ? 119.141 153.422 166.001 1.00 54.42  ? 503 GLN A OE1 1 
ATOM   3654 N NE2 . GLN A 1 477 ? 117.478 151.949 165.688 1.00 52.22  ? 503 GLN A NE2 1 
ATOM   3655 N N   . PRO A 1 478 ? 122.364 154.551 163.338 1.00 45.06  ? 504 PRO A N   1 
ATOM   3656 C CA  . PRO A 1 478 ? 123.638 155.214 163.055 1.00 44.29  ? 504 PRO A CA  1 
ATOM   3657 C C   . PRO A 1 478 ? 124.747 154.696 163.953 1.00 44.81  ? 504 PRO A C   1 
ATOM   3658 O O   . PRO A 1 478 ? 124.515 154.265 165.085 1.00 45.77  ? 504 PRO A O   1 
ATOM   3659 C CB  . PRO A 1 478 ? 123.338 156.690 163.336 1.00 46.16  ? 504 PRO A CB  1 
ATOM   3660 C CG  . PRO A 1 478 ? 122.219 156.656 164.320 1.00 44.64  ? 504 PRO A CG  1 
ATOM   3661 C CD  . PRO A 1 478 ? 121.386 155.466 163.948 1.00 46.74  ? 504 PRO A CD  1 
ATOM   3662 N N   . LEU A 1 479 ? 125.969 154.743 163.432 1.00 49.19  ? 505 LEU A N   1 
ATOM   3663 C CA  . LEU A 1 479 ? 127.129 154.334 164.210 1.00 46.70  ? 505 LEU A CA  1 
ATOM   3664 C C   . LEU A 1 479 ? 127.455 155.406 165.239 1.00 53.16  ? 505 LEU A C   1 
ATOM   3665 O O   . LEU A 1 479 ? 127.520 156.595 164.913 1.00 59.14  ? 505 LEU A O   1 
ATOM   3666 C CB  . LEU A 1 479 ? 128.327 154.088 163.293 1.00 48.61  ? 505 LEU A CB  1 
ATOM   3667 C CG  . LEU A 1 479 ? 129.441 153.142 163.754 1.00 47.54  ? 505 LEU A CG  1 
ATOM   3668 C CD1 . LEU A 1 479 ? 130.324 152.766 162.579 1.00 49.59  ? 505 LEU A CD1 1 
ATOM   3669 C CD2 . LEU A 1 479 ? 130.289 153.736 164.869 1.00 49.11  ? 505 LEU A CD2 1 
ATOM   3670 N N   . LEU A 1 480 ? 127.661 154.986 166.487 1.00 52.95  ? 506 LEU A N   1 
ATOM   3671 C CA  . LEU A 1 480 ? 128.025 155.911 167.558 1.00 53.01  ? 506 LEU A CA  1 
ATOM   3672 C C   . LEU A 1 480 ? 129.495 156.278 167.379 1.00 62.97  ? 506 LEU A C   1 
ATOM   3673 O O   . LEU A 1 480 ? 130.389 155.798 168.081 1.00 67.78  ? 506 LEU A O   1 
ATOM   3674 C CB  . LEU A 1 480 ? 127.753 155.292 168.922 1.00 49.91  ? 506 LEU A CB  1 
ATOM   3675 C CG  . LEU A 1 480 ? 126.293 154.949 169.225 1.00 51.98  ? 506 LEU A CG  1 
ATOM   3676 C CD1 . LEU A 1 480 ? 126.160 154.362 170.617 1.00 56.00  ? 506 LEU A CD1 1 
ATOM   3677 C CD2 . LEU A 1 480 ? 125.410 156.174 169.078 1.00 54.20  ? 506 LEU A CD2 1 
ATOM   3678 N N   . MET A 1 481 ? 129.741 157.156 166.405 1.00 77.09  ? 507 MET A N   1 
ATOM   3679 C CA  . MET A 1 481 ? 131.102 157.569 166.086 1.00 76.60  ? 507 MET A CA  1 
ATOM   3680 C C   . MET A 1 481 ? 131.667 158.519 167.131 1.00 74.73  ? 507 MET A C   1 
ATOM   3681 O O   . MET A 1 481 ? 132.889 158.588 167.305 1.00 72.51  ? 507 MET A O   1 
ATOM   3682 C CB  . MET A 1 481 ? 131.140 158.222 164.703 1.00 75.13  ? 507 MET A CB  1 
ATOM   3683 C CG  . MET A 1 481 ? 132.539 158.440 164.153 1.00 75.91  ? 507 MET A CG  1 
ATOM   3684 S SD  . MET A 1 481 ? 133.440 156.897 163.921 1.00 82.28  ? 507 MET A SD  1 
ATOM   3685 C CE  . MET A 1 481 ? 132.383 156.066 162.739 1.00 74.01  ? 507 MET A CE  1 
ATOM   3686 N N   . ASP A 1 482 ? 130.799 159.257 167.828 1.00 72.26  ? 508 ASP A N   1 
ATOM   3687 C CA  . ASP A 1 482 ? 131.264 160.152 168.882 1.00 73.18  ? 508 ASP A CA  1 
ATOM   3688 C C   . ASP A 1 482 ? 132.006 159.397 169.977 1.00 76.55  ? 508 ASP A C   1 
ATOM   3689 O O   . ASP A 1 482 ? 132.865 159.975 170.653 1.00 78.67  ? 508 ASP A O   1 
ATOM   3690 C CB  . ASP A 1 482 ? 130.084 160.928 169.468 1.00 77.84  ? 508 ASP A CB  1 
ATOM   3691 C CG  . ASP A 1 482 ? 128.932 160.027 169.868 1.00 80.94  ? 508 ASP A CG  1 
ATOM   3692 O OD1 . ASP A 1 482 ? 129.035 159.355 170.915 1.00 81.59  ? 508 ASP A OD1 1 
ATOM   3693 O OD2 . ASP A 1 482 ? 127.921 159.992 169.134 1.00 79.33  ? 508 ASP A OD2 1 
ATOM   3694 N N   . LEU A 1 483 ? 131.697 158.117 170.168 1.00 68.72  ? 509 LEU A N   1 
ATOM   3695 C CA  . LEU A 1 483 ? 132.416 157.291 171.137 1.00 67.78  ? 509 LEU A CA  1 
ATOM   3696 C C   . LEU A 1 483 ? 133.657 156.656 170.514 1.00 68.69  ? 509 LEU A C   1 
ATOM   3697 O O   . LEU A 1 483 ? 133.878 155.450 170.603 1.00 70.88  ? 509 LEU A O   1 
ATOM   3698 C CB  . LEU A 1 483 ? 131.483 156.225 171.697 1.00 61.40  ? 509 LEU A CB  1 
ATOM   3699 C CG  . LEU A 1 483 ? 130.217 156.716 172.395 1.00 63.33  ? 509 LEU A CG  1 
ATOM   3700 C CD1 . LEU A 1 483 ? 129.241 155.571 172.577 1.00 64.56  ? 509 LEU A CD1 1 
ATOM   3701 C CD2 . LEU A 1 483 ? 130.555 157.349 173.734 1.00 67.24  ? 509 LEU A CD2 1 
ATOM   3702 N N   . SER A 1 484 ? 134.480 157.481 169.874 1.00 74.70  ? 510 SER A N   1 
ATOM   3703 C CA  . SER A 1 484 ? 135.738 157.037 169.286 1.00 74.57  ? 510 SER A CA  1 
ATOM   3704 C C   . SER A 1 484 ? 136.873 156.929 170.305 1.00 78.76  ? 510 SER A C   1 
ATOM   3705 O O   . SER A 1 484 ? 137.555 155.896 170.339 1.00 79.64  ? 510 SER A O   1 
ATOM   3706 C CB  . SER A 1 484 ? 136.143 157.969 168.140 1.00 77.53  ? 510 SER A CB  1 
ATOM   3707 O OG  . SER A 1 484 ? 135.167 157.969 167.113 1.00 79.51  ? 510 SER A OG  1 
ATOM   3708 N N   . PRO A 1 485 ? 137.128 157.947 171.140 1.00 74.20  ? 511 PRO A N   1 
ATOM   3709 C CA  . PRO A 1 485 ? 138.302 157.870 172.030 1.00 72.58  ? 511 PRO A CA  1 
ATOM   3710 C C   . PRO A 1 485 ? 138.221 156.766 173.069 1.00 69.72  ? 511 PRO A C   1 
ATOM   3711 O O   . PRO A 1 485 ? 139.269 156.325 173.563 1.00 71.23  ? 511 PRO A O   1 
ATOM   3712 C CB  . PRO A 1 485 ? 138.334 159.256 172.689 1.00 70.41  ? 511 PRO A CB  1 
ATOM   3713 C CG  . PRO A 1 485 ? 136.935 159.727 172.630 1.00 68.09  ? 511 PRO A CG  1 
ATOM   3714 C CD  . PRO A 1 485 ? 136.412 159.225 171.322 1.00 68.34  ? 511 PRO A CD  1 
ATOM   3715 N N   . TRP A 1 486 ? 137.019 156.282 173.392 1.00 58.70  ? 512 TRP A N   1 
ATOM   3716 C CA  . TRP A 1 486 ? 136.878 155.275 174.435 1.00 61.51  ? 512 TRP A CA  1 
ATOM   3717 C C   . TRP A 1 486 ? 137.670 154.013 174.131 1.00 67.03  ? 512 TRP A C   1 
ATOM   3718 O O   . TRP A 1 486 ? 138.019 153.276 175.060 1.00 72.66  ? 512 TRP A O   1 
ATOM   3719 C CB  . TRP A 1 486 ? 135.405 154.922 174.632 1.00 64.51  ? 512 TRP A CB  1 
ATOM   3720 C CG  . TRP A 1 486 ? 134.662 155.877 175.510 1.00 67.38  ? 512 TRP A CG  1 
ATOM   3721 C CD1 . TRP A 1 486 ? 134.022 157.017 175.124 1.00 69.55  ? 512 TRP A CD1 1 
ATOM   3722 C CD2 . TRP A 1 486 ? 134.473 155.769 176.925 1.00 65.84  ? 512 TRP A CD2 1 
ATOM   3723 N NE1 . TRP A 1 486 ? 133.449 157.629 176.213 1.00 69.57  ? 512 TRP A NE1 1 
ATOM   3724 C CE2 . TRP A 1 486 ? 133.711 156.881 177.330 1.00 66.15  ? 512 TRP A CE2 1 
ATOM   3725 C CE3 . TRP A 1 486 ? 134.875 154.840 177.888 1.00 62.97  ? 512 TRP A CE3 1 
ATOM   3726 C CZ2 . TRP A 1 486 ? 133.345 157.090 178.656 1.00 62.92  ? 512 TRP A CZ2 1 
ATOM   3727 C CZ3 . TRP A 1 486 ? 134.511 155.049 179.203 1.00 63.80  ? 512 TRP A CZ3 1 
ATOM   3728 C CH2 . TRP A 1 486 ? 133.753 156.164 179.576 1.00 64.04  ? 512 TRP A CH2 1 
ATOM   3729 N N   . ARG A 1 487 ? 138.004 153.775 172.859 1.00 67.50  ? 513 ARG A N   1 
ATOM   3730 C CA  . ARG A 1 487 ? 138.767 152.588 172.496 1.00 67.16  ? 513 ARG A CA  1 
ATOM   3731 C C   . ARG A 1 487 ? 140.125 152.556 173.178 1.00 63.54  ? 513 ARG A C   1 
ATOM   3732 O O   . ARG A 1 487 ? 140.749 151.492 173.239 1.00 64.48  ? 513 ARG A O   1 
ATOM   3733 C CB  . ARG A 1 487 ? 138.945 152.515 170.980 1.00 66.66  ? 513 ARG A CB  1 
ATOM   3734 C CG  . ARG A 1 487 ? 137.643 152.466 170.205 1.00 65.91  ? 513 ARG A CG  1 
ATOM   3735 C CD  . ARG A 1 487 ? 137.893 152.273 168.720 1.00 66.11  ? 513 ARG A CD  1 
ATOM   3736 N NE  . ARG A 1 487 ? 138.605 153.399 168.130 1.00 66.90  ? 513 ARG A NE  1 
ATOM   3737 C CZ  . ARG A 1 487 ? 138.853 153.529 166.834 1.00 70.09  ? 513 ARG A CZ  1 
ATOM   3738 N NH1 . ARG A 1 487 ? 138.462 152.616 165.961 1.00 66.91  ? 513 ARG A NH1 1 
ATOM   3739 N NH2 . ARG A 1 487 ? 139.508 154.604 166.404 1.00 68.99  ? 513 ARG A NH2 1 
ATOM   3740 N N   . ALA A 1 488 ? 140.599 153.693 173.688 1.00 62.95  ? 514 ALA A N   1 
ATOM   3741 C CA  . ALA A 1 488 ? 141.779 153.657 174.541 1.00 65.51  ? 514 ALA A CA  1 
ATOM   3742 C C   . ALA A 1 488 ? 141.425 153.155 175.936 1.00 69.93  ? 514 ALA A C   1 
ATOM   3743 O O   . ALA A 1 488 ? 141.976 152.149 176.401 1.00 72.40  ? 514 ALA A O   1 
ATOM   3744 C CB  . ALA A 1 488 ? 142.421 155.043 174.613 1.00 64.96  ? 514 ALA A CB  1 
ATOM   3745 N N   . LYS A 1 489 ? 140.461 153.812 176.590 1.00 71.06  ? 515 LYS A N   1 
ATOM   3746 C CA  . LYS A 1 489 ? 140.163 153.508 177.987 1.00 67.91  ? 515 LYS A CA  1 
ATOM   3747 C C   . LYS A 1 489 ? 139.724 152.061 178.156 1.00 64.76  ? 515 LYS A C   1 
ATOM   3748 O O   . LYS A 1 489 ? 140.146 151.386 179.104 1.00 66.26  ? 515 LYS A O   1 
ATOM   3749 C CB  . LYS A 1 489 ? 139.092 154.465 178.513 1.00 64.30  ? 515 LYS A CB  1 
ATOM   3750 C CG  . LYS A 1 489 ? 138.932 154.477 180.027 1.00 66.05  ? 515 LYS A CG  1 
ATOM   3751 C CD  . LYS A 1 489 ? 137.848 153.517 180.493 1.00 70.35  ? 515 LYS A CD  1 
ATOM   3752 C CE  . LYS A 1 489 ? 137.668 153.579 182.001 1.00 70.99  ? 515 LYS A CE  1 
ATOM   3753 N NZ  . LYS A 1 489 ? 137.261 154.937 182.456 1.00 68.65  ? 515 LYS A NZ  1 
ATOM   3754 N N   . LEU A 1 490 ? 138.896 151.563 177.234 1.00 62.52  ? 516 LEU A N   1 
ATOM   3755 C CA  . LEU A 1 490 ? 138.453 150.176 177.310 1.00 61.79  ? 516 LEU A CA  1 
ATOM   3756 C C   . LEU A 1 490 ? 139.639 149.227 177.383 1.00 63.78  ? 516 LEU A C   1 
ATOM   3757 O O   . LEU A 1 490 ? 139.637 148.280 178.181 1.00 70.70  ? 516 LEU A O   1 
ATOM   3758 C CB  . LEU A 1 490 ? 137.573 149.837 176.107 1.00 63.14  ? 516 LEU A CB  1 
ATOM   3759 C CG  . LEU A 1 490 ? 136.340 150.710 175.876 1.00 64.16  ? 516 LEU A CG  1 
ATOM   3760 C CD1 . LEU A 1 490 ? 135.538 150.193 174.694 1.00 60.94  ? 516 LEU A CD1 1 
ATOM   3761 C CD2 . LEU A 1 490 ? 135.480 150.783 177.126 1.00 66.34  ? 516 LEU A CD2 1 
ATOM   3762 N N   . GLN A 1 491 ? 140.684 149.492 176.592 1.00 70.57  ? 517 GLN A N   1 
ATOM   3763 C CA  . GLN A 1 491 ? 141.836 148.599 176.594 1.00 70.58  ? 517 GLN A CA  1 
ATOM   3764 C C   . GLN A 1 491 ? 142.468 148.519 177.973 1.00 72.15  ? 517 GLN A C   1 
ATOM   3765 O O   . GLN A 1 491 ? 142.902 147.439 178.394 1.00 72.19  ? 517 GLN A O   1 
ATOM   3766 C CB  . GLN A 1 491 ? 142.862 149.055 175.558 1.00 70.63  ? 517 GLN A CB  1 
ATOM   3767 C CG  . GLN A 1 491 ? 142.508 148.656 174.140 1.00 73.32  ? 517 GLN A CG  1 
ATOM   3768 C CD  . GLN A 1 491 ? 142.444 147.152 173.965 1.00 78.07  ? 517 GLN A CD  1 
ATOM   3769 O OE1 . GLN A 1 491 ? 141.494 146.622 173.391 1.00 78.41  ? 517 GLN A OE1 1 
ATOM   3770 N NE2 . GLN A 1 491 ? 143.460 146.456 174.460 1.00 77.45  ? 517 GLN A NE2 1 
ATOM   3771 N N   . GLU A 1 492 ? 142.477 149.633 178.711 1.00 74.25  ? 518 GLU A N   1 
ATOM   3772 C CA  . GLU A 1 492 ? 143.006 149.604 180.068 1.00 73.45  ? 518 GLU A CA  1 
ATOM   3773 C C   . GLU A 1 492 ? 142.253 148.591 180.917 1.00 76.83  ? 518 GLU A C   1 
ATOM   3774 O O   . GLU A 1 492 ? 142.867 147.775 181.616 1.00 81.47  ? 518 GLU A O   1 
ATOM   3775 C CB  . GLU A 1 492 ? 142.928 150.996 180.692 1.00 74.26  ? 518 GLU A CB  1 
ATOM   3776 C CG  . GLU A 1 492 ? 143.254 151.033 182.174 1.00 78.12  ? 518 GLU A CG  1 
ATOM   3777 C CD  . GLU A 1 492 ? 142.994 152.393 182.793 1.00 79.71  ? 518 GLU A CD  1 
ATOM   3778 O OE1 . GLU A 1 492 ? 142.676 153.339 182.042 1.00 77.91  ? 518 GLU A OE1 1 
ATOM   3779 O OE2 . GLU A 1 492 ? 143.106 152.515 184.031 1.00 79.63  ? 518 GLU A OE2 1 
ATOM   3780 N N   . ILE A 1 493 ? 140.920 148.589 180.823 1.00 65.80  ? 519 ILE A N   1 
ATOM   3781 C CA  . ILE A 1 493 ? 140.146 147.619 181.584 1.00 57.94  ? 519 ILE A CA  1 
ATOM   3782 C C   . ILE A 1 493 ? 140.470 146.212 181.113 1.00 62.49  ? 519 ILE A C   1 
ATOM   3783 O O   . ILE A 1 493 ? 140.543 145.279 181.924 1.00 69.85  ? 519 ILE A O   1 
ATOM   3784 C CB  . ILE A 1 493 ? 138.641 147.925 181.475 1.00 58.16  ? 519 ILE A CB  1 
ATOM   3785 C CG1 . ILE A 1 493 ? 138.354 149.346 181.959 1.00 60.84  ? 519 ILE A CG1 1 
ATOM   3786 C CG2 . ILE A 1 493 ? 137.832 146.926 182.283 1.00 63.87  ? 519 ILE A CG2 1 
ATOM   3787 C CD1 . ILE A 1 493 ? 136.894 149.723 181.908 1.00 62.10  ? 519 ILE A CD1 1 
ATOM   3788 N N   . LYS A 1 494 ? 140.719 146.038 179.813 1.00 65.59  ? 520 LYS A N   1 
ATOM   3789 C CA  . LYS A 1 494 ? 141.070 144.721 179.302 1.00 64.99  ? 520 LYS A CA  1 
ATOM   3790 C C   . LYS A 1 494 ? 142.393 144.229 179.870 1.00 69.56  ? 520 LYS A C   1 
ATOM   3791 O O   . LYS A 1 494 ? 142.641 143.019 179.875 1.00 67.88  ? 520 LYS A O   1 
ATOM   3792 C CB  . LYS A 1 494 ? 141.131 144.748 177.775 1.00 65.83  ? 520 LYS A CB  1 
ATOM   3793 C CG  . LYS A 1 494 ? 141.019 143.382 177.122 1.00 70.46  ? 520 LYS A CG  1 
ATOM   3794 C CD  . LYS A 1 494 ? 139.604 142.841 177.225 1.00 71.05  ? 520 LYS A CD  1 
ATOM   3795 C CE  . LYS A 1 494 ? 138.621 143.745 176.500 1.00 73.32  ? 520 LYS A CE  1 
ATOM   3796 N NZ  . LYS A 1 494 ? 138.949 143.875 175.054 1.00 73.11  ? 520 LYS A NZ  1 
ATOM   3797 N N   . SER A 1 495 ? 143.244 145.137 180.352 1.00 75.55  ? 521 SER A N   1 
ATOM   3798 C CA  . SER A 1 495 ? 144.478 144.741 181.013 1.00 71.42  ? 521 SER A CA  1 
ATOM   3799 C C   . SER A 1 495 ? 144.308 144.543 182.511 1.00 69.16  ? 521 SER A C   1 
ATOM   3800 O O   . SER A 1 495 ? 145.170 143.920 183.140 1.00 69.50  ? 521 SER A O   1 
ATOM   3801 C CB  . SER A 1 495 ? 145.572 145.784 180.760 1.00 74.57  ? 521 SER A CB  1 
ATOM   3802 O OG  . SER A 1 495 ? 145.181 147.060 181.238 1.00 78.34  ? 521 SER A OG  1 
ATOM   3803 N N   . SER A 1 496 ? 143.224 145.054 183.094 1.00 69.93  ? 522 SER A N   1 
ATOM   3804 C CA  . SER A 1 496 ? 143.029 144.976 184.535 1.00 72.36  ? 522 SER A CA  1 
ATOM   3805 C C   . SER A 1 496 ? 142.387 143.671 184.985 1.00 77.45  ? 522 SER A C   1 
ATOM   3806 O O   . SER A 1 496 ? 142.280 143.439 186.193 1.00 79.29  ? 522 SER A O   1 
ATOM   3807 C CB  . SER A 1 496 ? 142.176 146.154 185.013 1.00 75.78  ? 522 SER A CB  1 
ATOM   3808 O OG  . SER A 1 496 ? 141.966 146.096 186.413 1.00 79.11  ? 522 SER A OG  1 
ATOM   3809 N N   . LEU A 1 497 ? 141.963 142.821 184.056 1.00 73.99  ? 523 LEU A N   1 
ATOM   3810 C CA  . LEU A 1 497 ? 141.227 141.615 184.394 1.00 71.58  ? 523 LEU A CA  1 
ATOM   3811 C C   . LEU A 1 497 ? 142.168 140.489 184.808 1.00 72.94  ? 523 LEU A C   1 
ATOM   3812 O O   . LEU A 1 497 ? 143.374 140.524 184.555 1.00 74.57  ? 523 LEU A O   1 
ATOM   3813 C CB  . LEU A 1 497 ? 140.366 141.161 183.216 1.00 69.87  ? 523 LEU A CB  1 
ATOM   3814 C CG  . LEU A 1 497 ? 139.280 142.132 182.757 1.00 70.90  ? 523 LEU A CG  1 
ATOM   3815 C CD1 . LEU A 1 497 ? 138.458 141.507 181.645 1.00 73.47  ? 523 LEU A CD1 1 
ATOM   3816 C CD2 . LEU A 1 497 ? 138.395 142.538 183.922 1.00 72.15  ? 523 LEU A CD2 1 
ATOM   3817 N N   . ASP A 1 498 ? 141.590 139.480 185.451 1.00 81.67  ? 524 ASP A N   1 
ATOM   3818 C CA  . ASP A 1 498 ? 142.321 138.303 185.888 1.00 79.11  ? 524 ASP A CA  1 
ATOM   3819 C C   . ASP A 1 498 ? 142.419 137.310 184.730 1.00 80.38  ? 524 ASP A C   1 
ATOM   3820 O O   . ASP A 1 498 ? 142.096 137.625 183.582 1.00 82.98  ? 524 ASP A O   1 
ATOM   3821 C CB  . ASP A 1 498 ? 141.648 137.689 187.113 1.00 79.85  ? 524 ASP A CB  1 
ATOM   3822 C CG  . ASP A 1 498 ? 141.489 138.681 188.248 1.00 86.97  ? 524 ASP A CG  1 
ATOM   3823 O OD1 . ASP A 1 498 ? 141.871 139.857 188.069 1.00 86.79  ? 524 ASP A OD1 1 
ATOM   3824 O OD2 . ASP A 1 498 ? 140.982 138.286 189.320 1.00 86.34  ? 524 ASP A OD2 1 
ATOM   3825 N N   . ASN A 1 499 ? 142.870 136.092 185.023 1.00 79.09  ? 525 ASN A N   1 
ATOM   3826 C CA  . ASN A 1 499 ? 143.107 135.101 183.983 1.00 84.42  ? 525 ASN A CA  1 
ATOM   3827 C C   . ASN A 1 499 ? 141.837 134.394 183.524 1.00 81.95  ? 525 ASN A C   1 
ATOM   3828 O O   . ASN A 1 499 ? 141.875 133.692 182.508 1.00 83.29  ? 525 ASN A O   1 
ATOM   3829 C CB  . ASN A 1 499 ? 144.124 134.067 184.476 1.00 86.60  ? 525 ASN A CB  1 
ATOM   3830 C CG  . ASN A 1 499 ? 144.752 133.278 183.343 1.00 87.08  ? 525 ASN A CG  1 
ATOM   3831 O OD1 . ASN A 1 499 ? 144.717 133.697 182.186 1.00 87.67  ? 525 ASN A OD1 1 
ATOM   3832 N ND2 . ASN A 1 499 ? 145.336 132.132 183.673 1.00 85.64  ? 525 ASN A ND2 1 
ATOM   3833 N N   . HIS A 1 500 ? 140.718 134.561 184.230 1.00 67.59  ? 526 HIS A N   1 
ATOM   3834 C CA  . HIS A 1 500 ? 139.478 133.890 183.870 1.00 68.89  ? 526 HIS A CA  1 
ATOM   3835 C C   . HIS A 1 500 ? 138.298 134.827 183.659 1.00 71.52  ? 526 HIS A C   1 
ATOM   3836 O O   . HIS A 1 500 ? 137.278 134.389 183.116 1.00 72.53  ? 526 HIS A O   1 
ATOM   3837 C CB  . HIS A 1 500 ? 139.100 132.851 184.937 1.00 68.44  ? 526 HIS A CB  1 
ATOM   3838 C CG  . HIS A 1 500 ? 139.972 131.635 184.930 1.00 75.06  ? 526 HIS A CG  1 
ATOM   3839 N ND1 . HIS A 1 500 ? 139.911 130.683 183.936 1.00 72.29  ? 526 HIS A ND1 1 
ATOM   3840 C CD2 . HIS A 1 500 ? 140.925 131.215 185.795 1.00 75.62  ? 526 HIS A CD2 1 
ATOM   3841 C CE1 . HIS A 1 500 ? 140.789 129.729 184.189 1.00 72.34  ? 526 HIS A CE1 1 
ATOM   3842 N NE2 . HIS A 1 500 ? 141.418 130.028 185.311 1.00 75.61  ? 526 HIS A NE2 1 
ATOM   3843 N N   . THR A 1 501 ? 138.401 136.089 184.061 1.00 57.07  ? 527 THR A N   1 
ATOM   3844 C CA  . THR A 1 501 ? 137.306 137.028 183.888 1.00 47.00  ? 527 THR A CA  1 
ATOM   3845 C C   . THR A 1 501 ? 137.225 137.495 182.439 1.00 49.56  ? 527 THR A C   1 
ATOM   3846 O O   . THR A 1 501 ? 138.234 137.582 181.734 1.00 56.62  ? 527 THR A O   1 
ATOM   3847 C CB  . THR A 1 501 ? 137.485 138.229 184.817 1.00 51.07  ? 527 THR A CB  1 
ATOM   3848 O OG1 . THR A 1 501 ? 137.908 137.775 186.108 1.00 57.61  ? 527 THR A OG1 1 
ATOM   3849 C CG2 . THR A 1 501 ? 136.183 138.981 184.971 1.00 51.27  ? 527 THR A CG2 1 
ATOM   3850 N N   . GLU A 1 502 ? 136.005 137.794 181.996 1.00 47.75  ? 528 GLU A N   1 
ATOM   3851 C CA  . GLU A 1 502 ? 135.758 138.318 180.661 1.00 46.52  ? 528 GLU A CA  1 
ATOM   3852 C C   . GLU A 1 502 ? 134.825 139.517 180.750 1.00 53.35  ? 528 GLU A C   1 
ATOM   3853 O O   . GLU A 1 502 ? 134.046 139.651 181.700 1.00 60.38  ? 528 GLU A O   1 
ATOM   3854 C CB  . GLU A 1 502 ? 135.155 137.256 179.737 1.00 47.99  ? 528 GLU A CB  1 
ATOM   3855 C CG  . GLU A 1 502 ? 136.023 136.025 179.556 1.00 56.03  ? 528 GLU A CG  1 
ATOM   3856 C CD  . GLU A 1 502 ? 135.412 135.021 178.601 1.00 63.92  ? 528 GLU A CD  1 
ATOM   3857 O OE1 . GLU A 1 502 ? 134.517 135.410 177.820 1.00 62.38  ? 528 GLU A OE1 1 
ATOM   3858 O OE2 . GLU A 1 502 ? 135.823 133.843 178.631 1.00 63.90  ? 528 GLU A OE2 1 
ATOM   3859 N N   . VAL A 1 503 ? 134.914 140.392 179.749 1.00 37.48  ? 529 VAL A N   1 
ATOM   3860 C CA  . VAL A 1 503 ? 134.183 141.654 179.745 1.00 32.95  ? 529 VAL A CA  1 
ATOM   3861 C C   . VAL A 1 503 ? 133.591 141.891 178.361 1.00 40.91  ? 529 VAL A C   1 
ATOM   3862 O O   . VAL A 1 503 ? 134.201 141.553 177.342 1.00 48.80  ? 529 VAL A O   1 
ATOM   3863 C CB  . VAL A 1 503 ? 135.093 142.827 180.170 1.00 36.67  ? 529 VAL A CB  1 
ATOM   3864 C CG1 . VAL A 1 503 ? 136.238 143.004 179.189 1.00 42.91  ? 529 VAL A CG1 1 
ATOM   3865 C CG2 . VAL A 1 503 ? 134.292 144.110 180.304 1.00 44.90  ? 529 VAL A CG2 1 
ATOM   3866 N N   . VAL A 1 504 ? 132.383 142.452 178.332 1.00 44.22  ? 530 VAL A N   1 
ATOM   3867 C CA  . VAL A 1 504 ? 131.690 142.819 177.099 1.00 40.72  ? 530 VAL A CA  1 
ATOM   3868 C C   . VAL A 1 504 ? 131.145 144.233 177.265 1.00 46.68  ? 530 VAL A C   1 
ATOM   3869 O O   . VAL A 1 504 ? 130.443 144.517 178.241 1.00 55.84  ? 530 VAL A O   1 
ATOM   3870 C CB  . VAL A 1 504 ? 130.554 141.840 176.759 1.00 38.85  ? 530 VAL A CB  1 
ATOM   3871 C CG1 . VAL A 1 504 ? 129.755 142.348 175.574 1.00 43.37  ? 530 VAL A CG1 1 
ATOM   3872 C CG2 . VAL A 1 504 ? 131.111 140.459 176.468 1.00 37.61  ? 530 VAL A CG2 1 
ATOM   3873 N N   . PHE A 1 505 ? 131.452 145.111 176.315 1.00 44.26  ? 531 PHE A N   1 
ATOM   3874 C CA  . PHE A 1 505 ? 131.061 146.515 176.388 1.00 44.39  ? 531 PHE A CA  1 
ATOM   3875 C C   . PHE A 1 505 ? 129.860 146.765 175.485 1.00 46.31  ? 531 PHE A C   1 
ATOM   3876 O O   . PHE A 1 505 ? 129.845 146.326 174.331 1.00 51.51  ? 531 PHE A O   1 
ATOM   3877 C CB  . PHE A 1 505 ? 132.223 147.423 175.988 1.00 44.38  ? 531 PHE A CB  1 
ATOM   3878 C CG  . PHE A 1 505 ? 133.439 147.262 176.850 1.00 48.87  ? 531 PHE A CG  1 
ATOM   3879 C CD1 . PHE A 1 505 ? 133.533 147.916 178.066 1.00 48.78  ? 531 PHE A CD1 1 
ATOM   3880 C CD2 . PHE A 1 505 ? 134.489 146.458 176.446 1.00 51.02  ? 531 PHE A CD2 1 
ATOM   3881 C CE1 . PHE A 1 505 ? 134.650 147.769 178.861 1.00 48.39  ? 531 PHE A CE1 1 
ATOM   3882 C CE2 . PHE A 1 505 ? 135.606 146.309 177.237 1.00 48.41  ? 531 PHE A CE2 1 
ATOM   3883 C CZ  . PHE A 1 505 ? 135.687 146.965 178.445 1.00 48.58  ? 531 PHE A CZ  1 
ATOM   3884 N N   . ILE A 1 506 ? 128.859 147.474 176.009 1.00 44.84  ? 532 ILE A N   1 
ATOM   3885 C CA  . ILE A 1 506 ? 127.581 147.661 175.333 1.00 42.95  ? 532 ILE A CA  1 
ATOM   3886 C C   . ILE A 1 506 ? 127.259 149.147 175.290 1.00 46.76  ? 532 ILE A C   1 
ATOM   3887 O O   . ILE A 1 506 ? 127.439 149.856 176.287 1.00 56.11  ? 532 ILE A O   1 
ATOM   3888 C CB  . ILE A 1 506 ? 126.451 146.887 176.041 1.00 46.29  ? 532 ILE A CB  1 
ATOM   3889 C CG1 . ILE A 1 506 ? 126.737 145.386 176.031 1.00 51.57  ? 532 ILE A CG1 1 
ATOM   3890 C CG2 . ILE A 1 506 ? 125.110 147.176 175.396 1.00 49.31  ? 532 ILE A CG2 1 
ATOM   3891 C CD1 . ILE A 1 506 ? 126.804 144.789 174.648 1.00 48.53  ? 532 ILE A CD1 1 
ATOM   3892 N N   . ALA A 1 507 ? 126.792 149.617 174.135 1.00 44.63  ? 533 ALA A N   1 
ATOM   3893 C CA  . ALA A 1 507 ? 126.273 150.967 173.964 1.00 44.12  ? 533 ALA A CA  1 
ATOM   3894 C C   . ALA A 1 507 ? 124.870 150.876 173.382 1.00 46.79  ? 533 ALA A C   1 
ATOM   3895 O O   . ALA A 1 507 ? 124.671 150.251 172.335 1.00 51.59  ? 533 ALA A O   1 
ATOM   3896 C CB  . ALA A 1 507 ? 127.178 151.798 173.054 1.00 44.42  ? 533 ALA A CB  1 
ATOM   3897 N N   . ASP A 1 508 ? 123.904 151.498 174.052 1.00 43.61  ? 534 ASP A N   1 
ATOM   3898 C CA  . ASP A 1 508 ? 122.499 151.340 173.713 1.00 44.55  ? 534 ASP A CA  1 
ATOM   3899 C C   . ASP A 1 508 ? 121.834 152.694 173.507 1.00 47.90  ? 534 ASP A C   1 
ATOM   3900 O O   . ASP A 1 508 ? 122.212 153.696 174.126 1.00 55.60  ? 534 ASP A O   1 
ATOM   3901 C CB  . ASP A 1 508 ? 121.756 150.557 174.801 1.00 49.83  ? 534 ASP A CB  1 
ATOM   3902 C CG  . ASP A 1 508 ? 120.504 149.881 174.279 1.00 57.25  ? 534 ASP A CG  1 
ATOM   3903 O OD1 . ASP A 1 508 ? 120.276 149.918 173.051 1.00 58.61  ? 534 ASP A OD1 1 
ATOM   3904 O OD2 . ASP A 1 508 ? 119.749 149.311 175.094 1.00 58.08  ? 534 ASP A OD2 1 
ATOM   3905 N N   . PHE A 1 509 ? 120.836 152.703 172.626 1.00 45.53  ? 535 PHE A N   1 
ATOM   3906 C CA  . PHE A 1 509 ? 120.088 153.893 172.261 1.00 40.76  ? 535 PHE A CA  1 
ATOM   3907 C C   . PHE A 1 509 ? 118.950 154.147 173.245 1.00 40.79  ? 535 PHE A C   1 
ATOM   3908 O O   . PHE A 1 509 ? 118.495 153.231 173.933 1.00 51.93  ? 535 PHE A O   1 
ATOM   3909 C CB  . PHE A 1 509 ? 119.534 153.742 170.847 1.00 39.86  ? 535 PHE A CB  1 
ATOM   3910 C CG  . PHE A 1 509 ? 120.591 153.665 169.785 1.00 38.45  ? 535 PHE A CG  1 
ATOM   3911 C CD1 . PHE A 1 509 ? 121.161 152.454 169.442 1.00 44.46  ? 535 PHE A CD1 1 
ATOM   3912 C CD2 . PHE A 1 509 ? 121.015 154.805 169.129 1.00 42.61  ? 535 PHE A CD2 1 
ATOM   3913 C CE1 . PHE A 1 509 ? 122.134 152.382 168.466 1.00 46.20  ? 535 PHE A CE1 1 
ATOM   3914 C CE2 . PHE A 1 509 ? 121.987 154.737 168.153 1.00 47.94  ? 535 PHE A CE2 1 
ATOM   3915 C CZ  . PHE A 1 509 ? 122.547 153.524 167.823 1.00 45.97  ? 535 PHE A CZ  1 
ATOM   3916 N N   . PRO A 1 510 ? 118.475 155.389 173.336 1.00 37.27  ? 536 PRO A N   1 
ATOM   3917 C CA  . PRO A 1 510 ? 117.349 155.678 174.232 1.00 41.92  ? 536 PRO A CA  1 
ATOM   3918 C C   . PRO A 1 510 ? 116.059 155.034 173.750 1.00 48.57  ? 536 PRO A C   1 
ATOM   3919 O O   . PRO A 1 510 ? 115.796 154.944 172.548 1.00 51.31  ? 536 PRO A O   1 
ATOM   3920 C CB  . PRO A 1 510 ? 117.252 157.207 174.196 1.00 41.99  ? 536 PRO A CB  1 
ATOM   3921 C CG  . PRO A 1 510 ? 117.873 157.590 172.902 1.00 45.04  ? 536 PRO A CG  1 
ATOM   3922 C CD  . PRO A 1 510 ? 118.985 156.610 172.690 1.00 45.52  ? 536 PRO A CD  1 
ATOM   3923 N N   . GLY A 1 511 ? 115.254 154.581 174.707 1.00 47.66  ? 537 GLY A N   1 
ATOM   3924 C CA  . GLY A 1 511 ? 113.969 153.986 174.402 1.00 41.54  ? 537 GLY A CA  1 
ATOM   3925 C C   . GLY A 1 511 ? 114.017 152.475 174.333 1.00 44.94  ? 537 GLY A C   1 
ATOM   3926 O O   . GLY A 1 511 ? 113.097 151.792 174.791 1.00 49.21  ? 537 GLY A O   1 
ATOM   3927 N N   . LEU A 1 512 ? 115.094 151.945 173.763 1.00 44.55  ? 538 LEU A N   1 
ATOM   3928 C CA  . LEU A 1 512 ? 115.245 150.512 173.582 1.00 44.35  ? 538 LEU A CA  1 
ATOM   3929 C C   . LEU A 1 512 ? 115.627 149.844 174.901 1.00 51.45  ? 538 LEU A C   1 
ATOM   3930 O O   . LEU A 1 512 ? 116.004 150.497 175.877 1.00 51.67  ? 538 LEU A O   1 
ATOM   3931 C CB  . LEU A 1 512 ? 116.295 150.216 172.511 1.00 45.46  ? 538 LEU A CB  1 
ATOM   3932 C CG  . LEU A 1 512 ? 115.978 150.486 171.036 1.00 47.36  ? 538 LEU A CG  1 
ATOM   3933 C CD1 . LEU A 1 512 ? 115.885 151.971 170.721 1.00 50.31  ? 538 LEU A CD1 1 
ATOM   3934 C CD2 . LEU A 1 512 ? 117.023 149.832 170.154 1.00 45.78  ? 538 LEU A CD2 1 
ATOM   3935 N N   . HIS A 1 513 ? 115.525 148.517 174.922 1.00 57.97  ? 539 HIS A N   1 
ATOM   3936 C CA  . HIS A 1 513 ? 115.883 147.745 176.101 1.00 52.00  ? 539 HIS A CA  1 
ATOM   3937 C C   . HIS A 1 513 ? 116.455 146.405 175.668 1.00 54.53  ? 539 HIS A C   1 
ATOM   3938 O O   . HIS A 1 513 ? 116.212 145.932 174.555 1.00 56.20  ? 539 HIS A O   1 
ATOM   3939 C CB  . HIS A 1 513 ? 114.679 147.538 177.026 1.00 50.54  ? 539 HIS A CB  1 
ATOM   3940 C CG  . HIS A 1 513 ? 113.583 146.719 176.422 1.00 48.14  ? 539 HIS A CG  1 
ATOM   3941 N ND1 . HIS A 1 513 ? 113.597 145.341 176.420 1.00 51.93  ? 539 HIS A ND1 1 
ATOM   3942 C CD2 . HIS A 1 513 ? 112.434 147.083 175.807 1.00 51.52  ? 539 HIS A CD2 1 
ATOM   3943 C CE1 . HIS A 1 513 ? 112.506 144.892 175.827 1.00 56.86  ? 539 HIS A CE1 1 
ATOM   3944 N NE2 . HIS A 1 513 ? 111.783 145.929 175.445 1.00 59.73  ? 539 HIS A NE2 1 
ATOM   3945 N N   . LEU A 1 514 ? 117.222 145.796 176.568 1.00 54.28  ? 540 LEU A N   1 
ATOM   3946 C CA  . LEU A 1 514 ? 117.859 144.510 176.321 1.00 50.89  ? 540 LEU A CA  1 
ATOM   3947 C C   . LEU A 1 514 ? 117.401 143.502 177.364 1.00 48.41  ? 540 LEU A C   1 
ATOM   3948 O O   . LEU A 1 514 ? 117.490 143.766 178.567 1.00 56.95  ? 540 LEU A O   1 
ATOM   3949 C CB  . LEU A 1 514 ? 119.383 144.635 176.346 1.00 50.27  ? 540 LEU A CB  1 
ATOM   3950 C CG  . LEU A 1 514 ? 120.162 143.332 176.179 1.00 51.27  ? 540 LEU A CG  1 
ATOM   3951 C CD1 . LEU A 1 514 ? 119.822 142.671 174.854 1.00 54.61  ? 540 LEU A CD1 1 
ATOM   3952 C CD2 . LEU A 1 514 ? 121.651 143.586 176.281 1.00 50.68  ? 540 LEU A CD2 1 
ATOM   3953 N N   . GLU A 1 515 ? 116.918 142.352 176.903 1.00 54.19  ? 541 GLU A N   1 
ATOM   3954 C CA  . GLU A 1 515 ? 116.496 141.261 177.771 1.00 53.05  ? 541 GLU A CA  1 
ATOM   3955 C C   . GLU A 1 515 ? 117.527 140.145 177.695 1.00 56.26  ? 541 GLU A C   1 
ATOM   3956 O O   . GLU A 1 515 ? 117.866 139.685 176.600 1.00 63.35  ? 541 GLU A O   1 
ATOM   3957 C CB  . GLU A 1 515 ? 115.116 140.741 177.365 1.00 55.54  ? 541 GLU A CB  1 
ATOM   3958 C CG  . GLU A 1 515 ? 114.608 139.589 178.215 1.00 61.78  ? 541 GLU A CG  1 
ATOM   3959 C CD  . GLU A 1 515 ? 113.221 139.130 177.807 1.00 70.17  ? 541 GLU A CD  1 
ATOM   3960 O OE1 . GLU A 1 515 ? 112.392 139.990 177.439 1.00 67.23  ? 541 GLU A OE1 1 
ATOM   3961 O OE2 . GLU A 1 515 ? 112.959 137.910 177.853 1.00 70.85  ? 541 GLU A OE2 1 
ATOM   3962 N N   . ASN A 1 516 ? 118.018 139.709 178.851 1.00 44.27  ? 542 ASN A N   1 
ATOM   3963 C CA  . ASN A 1 516 ? 119.118 138.761 178.913 1.00 42.83  ? 542 ASN A CA  1 
ATOM   3964 C C   . ASN A 1 516 ? 118.806 137.671 179.928 1.00 44.96  ? 542 ASN A C   1 
ATOM   3965 O O   . ASN A 1 516 ? 118.064 137.888 180.891 1.00 55.98  ? 542 ASN A O   1 
ATOM   3966 C CB  . ASN A 1 516 ? 120.432 139.467 179.276 1.00 44.34  ? 542 ASN A CB  1 
ATOM   3967 C CG  . ASN A 1 516 ? 121.626 138.541 179.230 1.00 50.88  ? 542 ASN A CG  1 
ATOM   3968 O OD1 . ASN A 1 516 ? 121.575 137.470 178.625 1.00 60.87  ? 542 ASN A OD1 1 
ATOM   3969 N ND2 . ASN A 1 516 ? 122.714 138.948 179.872 1.00 47.07  ? 542 ASN A ND2 1 
ATOM   3970 N N   . PHE A 1 517 ? 119.371 136.489 179.690 1.00 39.41  ? 543 PHE A N   1 
ATOM   3971 C CA  . PHE A 1 517 ? 119.202 135.331 180.566 1.00 40.69  ? 543 PHE A CA  1 
ATOM   3972 C C   . PHE A 1 517 ? 120.587 134.804 180.926 1.00 47.68  ? 543 PHE A C   1 
ATOM   3973 O O   . PHE A 1 517 ? 121.231 134.132 180.116 1.00 53.33  ? 543 PHE A O   1 
ATOM   3974 C CB  . PHE A 1 517 ? 118.359 134.253 179.894 1.00 42.21  ? 543 PHE A CB  1 
ATOM   3975 C CG  . PHE A 1 517 ? 118.208 133.004 180.712 1.00 42.78  ? 543 PHE A CG  1 
ATOM   3976 C CD1 . PHE A 1 517 ? 117.261 132.930 181.717 1.00 47.37  ? 543 PHE A CD1 1 
ATOM   3977 C CD2 . PHE A 1 517 ? 119.006 131.900 180.471 1.00 42.77  ? 543 PHE A CD2 1 
ATOM   3978 C CE1 . PHE A 1 517 ? 117.117 131.783 182.469 1.00 45.37  ? 543 PHE A CE1 1 
ATOM   3979 C CE2 . PHE A 1 517 ? 118.865 130.752 181.221 1.00 43.74  ? 543 PHE A CE2 1 
ATOM   3980 C CZ  . PHE A 1 517 ? 117.920 130.694 182.220 1.00 42.51  ? 543 PHE A CZ  1 
ATOM   3981 N N   . VAL A 1 518 ? 121.042 135.106 182.141 1.00 47.93  ? 544 VAL A N   1 
ATOM   3982 C CA  . VAL A 1 518 ? 122.328 134.604 182.606 1.00 37.55  ? 544 VAL A CA  1 
ATOM   3983 C C   . VAL A 1 518 ? 122.215 133.111 182.872 1.00 42.77  ? 544 VAL A C   1 
ATOM   3984 O O   . VAL A 1 518 ? 121.317 132.659 183.593 1.00 49.47  ? 544 VAL A O   1 
ATOM   3985 C CB  . VAL A 1 518 ? 122.781 135.361 183.862 1.00 38.55  ? 544 VAL A CB  1 
ATOM   3986 C CG1 . VAL A 1 518 ? 124.186 134.940 184.257 1.00 45.47  ? 544 VAL A CG1 1 
ATOM   3987 C CG2 . VAL A 1 518 ? 122.712 136.857 183.631 1.00 41.90  ? 544 VAL A CG2 1 
ATOM   3988 N N   . SER A 1 519 ? 123.126 132.336 182.290 1.00 41.82  ? 545 SER A N   1 
ATOM   3989 C CA  . SER A 1 519 ? 123.079 130.891 182.440 1.00 41.02  ? 545 SER A CA  1 
ATOM   3990 C C   . SER A 1 519 ? 123.449 130.490 183.866 1.00 51.32  ? 545 SER A C   1 
ATOM   3991 O O   . SER A 1 519 ? 123.968 131.284 184.655 1.00 63.66  ? 545 SER A O   1 
ATOM   3992 C CB  . SER A 1 519 ? 124.016 130.219 181.440 1.00 45.91  ? 545 SER A CB  1 
ATOM   3993 O OG  . SER A 1 519 ? 125.348 130.673 181.604 1.00 52.32  ? 545 SER A OG  1 
ATOM   3994 N N   . GLU A 1 520 ? 123.167 129.227 184.194 1.00 55.66  ? 546 GLU A N   1 
ATOM   3995 C CA  . GLU A 1 520 ? 123.414 128.746 185.549 1.00 55.45  ? 546 GLU A CA  1 
ATOM   3996 C C   . GLU A 1 520 ? 124.902 128.650 185.852 1.00 54.48  ? 546 GLU A C   1 
ATOM   3997 O O   . GLU A 1 520 ? 125.309 128.803 187.008 1.00 55.33  ? 546 GLU A O   1 
ATOM   3998 C CB  . GLU A 1 520 ? 122.744 127.389 185.755 1.00 56.58  ? 546 GLU A CB  1 
ATOM   3999 C CG  . GLU A 1 520 ? 121.257 127.378 185.442 1.00 61.30  ? 546 GLU A CG  1 
ATOM   4000 C CD  . GLU A 1 520 ? 120.634 126.008 185.624 1.00 65.17  ? 546 GLU A CD  1 
ATOM   4001 O OE1 . GLU A 1 520 ? 121.346 125.083 186.070 1.00 65.57  ? 546 GLU A OE1 1 
ATOM   4002 O OE2 . GLU A 1 520 ? 119.433 125.855 185.319 1.00 65.54  ? 546 GLU A OE2 1 
ATOM   4003 N N   . ASP A 1 521 ? 125.725 128.394 184.834 1.00 53.63  ? 547 ASP A N   1 
ATOM   4004 C CA  . ASP A 1 521 ? 127.159 128.263 185.056 1.00 56.86  ? 547 ASP A CA  1 
ATOM   4005 C C   . ASP A 1 521 ? 127.820 129.609 185.321 1.00 55.31  ? 547 ASP A C   1 
ATOM   4006 O O   . ASP A 1 521 ? 128.774 129.683 186.103 1.00 58.90  ? 547 ASP A O   1 
ATOM   4007 C CB  . ASP A 1 521 ? 127.814 127.577 183.858 1.00 56.32  ? 547 ASP A CB  1 
ATOM   4008 C CG  . ASP A 1 521 ? 127.303 126.167 183.644 1.00 63.05  ? 547 ASP A CG  1 
ATOM   4009 O OD1 . ASP A 1 521 ? 126.941 125.507 184.640 1.00 64.16  ? 547 ASP A OD1 1 
ATOM   4010 O OD2 . ASP A 1 521 ? 127.262 125.719 182.479 1.00 63.42  ? 547 ASP A OD2 1 
ATOM   4011 N N   . LEU A 1 522 ? 127.332 130.678 184.692 1.00 47.09  ? 548 LEU A N   1 
ATOM   4012 C CA  . LEU A 1 522 ? 127.986 131.985 184.755 1.00 40.39  ? 548 LEU A CA  1 
ATOM   4013 C C   . LEU A 1 522 ? 127.636 132.684 186.069 1.00 45.99  ? 548 LEU A C   1 
ATOM   4014 O O   . LEU A 1 522 ? 126.948 133.706 186.116 1.00 52.28  ? 548 LEU A O   1 
ATOM   4015 C CB  . LEU A 1 522 ? 127.596 132.835 183.554 1.00 37.47  ? 548 LEU A CB  1 
ATOM   4016 C CG  . LEU A 1 522 ? 128.565 132.852 182.371 1.00 44.35  ? 548 LEU A CG  1 
ATOM   4017 C CD1 . LEU A 1 522 ? 128.842 131.447 181.868 1.00 49.61  ? 548 LEU A CD1 1 
ATOM   4018 C CD2 . LEU A 1 522 ? 128.020 133.725 181.254 1.00 48.55  ? 548 LEU A CD2 1 
ATOM   4019 N N   . GLY A 1 523 ? 128.132 132.104 187.158 1.00 48.37  ? 549 GLY A N   1 
ATOM   4020 C CA  . GLY A 1 523 ? 128.051 132.764 188.442 1.00 42.66  ? 549 GLY A CA  1 
ATOM   4021 C C   . GLY A 1 523 ? 129.020 133.925 188.543 1.00 46.16  ? 549 GLY A C   1 
ATOM   4022 O O   . GLY A 1 523 ? 129.979 134.043 187.779 1.00 53.56  ? 549 GLY A O   1 
ATOM   4023 N N   . ASN A 1 524 ? 128.758 134.807 189.508 1.00 40.58  ? 550 ASN A N   1 
ATOM   4024 C CA  . ASN A 1 524 ? 129.557 136.010 189.740 1.00 44.78  ? 550 ASN A CA  1 
ATOM   4025 C C   . ASN A 1 524 ? 129.581 136.899 188.494 1.00 49.46  ? 550 ASN A C   1 
ATOM   4026 O O   . ASN A 1 524 ? 130.630 137.185 187.915 1.00 54.19  ? 550 ASN A O   1 
ATOM   4027 C CB  . ASN A 1 524 ? 130.977 135.653 190.195 1.00 46.48  ? 550 ASN A CB  1 
ATOM   4028 C CG  . ASN A 1 524 ? 131.714 136.839 190.787 1.00 52.25  ? 550 ASN A CG  1 
ATOM   4029 O OD1 . ASN A 1 524 ? 131.228 137.483 191.717 1.00 59.31  ? 550 ASN A OD1 1 
ATOM   4030 N ND2 . ASN A 1 524 ? 132.893 137.130 190.253 1.00 48.80  ? 550 ASN A ND2 1 
ATOM   4031 N N   . THR A 1 525 ? 128.384 137.325 188.088 1.00 43.16  ? 551 THR A N   1 
ATOM   4032 C CA  . THR A 1 525 ? 128.210 138.232 186.962 1.00 37.64  ? 551 THR A CA  1 
ATOM   4033 C C   . THR A 1 525 ? 127.801 139.601 187.487 1.00 46.15  ? 551 THR A C   1 
ATOM   4034 O O   . THR A 1 525 ? 126.868 139.710 188.290 1.00 51.81  ? 551 THR A O   1 
ATOM   4035 C CB  . THR A 1 525 ? 127.162 137.703 185.983 1.00 42.78  ? 551 THR A CB  1 
ATOM   4036 O OG1 . THR A 1 525 ? 127.604 136.454 185.439 1.00 52.78  ? 551 THR A OG1 1 
ATOM   4037 C CG2 . THR A 1 525 ? 126.945 138.690 184.850 1.00 46.26  ? 551 THR A CG2 1 
ATOM   4038 N N   . SER A 1 526 ? 128.502 140.638 187.036 1.00 49.28  ? 552 SER A N   1 
ATOM   4039 C CA  . SER A 1 526 ? 128.293 141.991 187.523 1.00 42.79  ? 552 SER A CA  1 
ATOM   4040 C C   . SER A 1 526 ? 128.130 142.945 186.350 1.00 44.70  ? 552 SER A C   1 
ATOM   4041 O O   . SER A 1 526 ? 128.699 142.740 185.274 1.00 55.32  ? 552 SER A O   1 
ATOM   4042 C CB  . SER A 1 526 ? 129.456 142.454 188.406 1.00 48.92  ? 552 SER A CB  1 
ATOM   4043 O OG  . SER A 1 526 ? 130.677 142.444 187.687 1.00 51.70  ? 552 SER A OG  1 
ATOM   4044 N N   . ILE A 1 527 ? 127.341 143.990 186.574 1.00 43.91  ? 553 ILE A N   1 
ATOM   4045 C CA  . ILE A 1 527 ? 127.064 145.012 185.572 1.00 44.52  ? 553 ILE A CA  1 
ATOM   4046 C C   . ILE A 1 527 ? 127.467 146.365 186.141 1.00 51.55  ? 553 ILE A C   1 
ATOM   4047 O O   . ILE A 1 527 ? 127.077 146.718 187.261 1.00 60.50  ? 553 ILE A O   1 
ATOM   4048 C CB  . ILE A 1 527 ? 125.584 145.005 185.146 1.00 42.87  ? 553 ILE A CB  1 
ATOM   4049 C CG1 . ILE A 1 527 ? 125.274 146.208 184.257 1.00 38.68  ? 553 ILE A CG1 1 
ATOM   4050 C CG2 . ILE A 1 527 ? 124.666 144.971 186.359 1.00 49.74  ? 553 ILE A CG2 1 
ATOM   4051 C CD1 . ILE A 1 527 ? 123.849 146.250 183.777 1.00 47.84  ? 553 ILE A CD1 1 
ATOM   4052 N N   . GLN A 1 528 ? 128.261 147.109 185.376 1.00 52.99  ? 554 GLN A N   1 
ATOM   4053 C CA  . GLN A 1 528 ? 128.733 148.428 185.766 1.00 48.86  ? 554 GLN A CA  1 
ATOM   4054 C C   . GLN A 1 528 ? 128.382 149.432 184.679 1.00 51.76  ? 554 GLN A C   1 
ATOM   4055 O O   . GLN A 1 528 ? 128.512 149.139 183.486 1.00 58.73  ? 554 GLN A O   1 
ATOM   4056 C CB  . GLN A 1 528 ? 130.245 148.419 186.008 1.00 52.20  ? 554 GLN A CB  1 
ATOM   4057 C CG  . GLN A 1 528 ? 130.804 149.730 186.530 1.00 59.28  ? 554 GLN A CG  1 
ATOM   4058 C CD  . GLN A 1 528 ? 132.291 149.657 186.808 1.00 59.75  ? 554 GLN A CD  1 
ATOM   4059 O OE1 . GLN A 1 528 ? 132.928 148.631 186.572 1.00 59.55  ? 554 GLN A OE1 1 
ATOM   4060 N NE2 . GLN A 1 528 ? 132.852 150.748 187.315 1.00 56.96  ? 554 GLN A NE2 1 
ATOM   4061 N N   . LEU A 1 529 ? 127.941 150.615 185.092 1.00 52.12  ? 555 LEU A N   1 
ATOM   4062 C CA  . LEU A 1 529 ? 127.562 151.676 184.171 1.00 55.65  ? 555 LEU A CA  1 
ATOM   4063 C C   . LEU A 1 529 ? 128.727 152.640 183.997 1.00 61.60  ? 555 LEU A C   1 
ATOM   4064 O O   . LEU A 1 529 ? 129.299 153.115 184.984 1.00 65.66  ? 555 LEU A O   1 
ATOM   4065 C CB  . LEU A 1 529 ? 126.328 152.422 184.676 1.00 50.93  ? 555 LEU A CB  1 
ATOM   4066 C CG  . LEU A 1 529 ? 125.819 153.544 183.774 1.00 51.03  ? 555 LEU A CG  1 
ATOM   4067 C CD1 . LEU A 1 529 ? 125.499 153.006 182.392 1.00 57.51  ? 555 LEU A CD1 1 
ATOM   4068 C CD2 . LEU A 1 529 ? 124.601 154.204 184.382 1.00 55.14  ? 555 LEU A CD2 1 
ATOM   4069 N N   . LEU A 1 530 ? 129.073 152.927 182.744 1.00 56.05  ? 556 LEU A N   1 
ATOM   4070 C CA  . LEU A 1 530 ? 130.193 153.803 182.426 1.00 47.42  ? 556 LEU A CA  1 
ATOM   4071 C C   . LEU A 1 530 ? 129.759 155.205 182.023 1.00 54.49  ? 556 LEU A C   1 
ATOM   4072 O O   . LEU A 1 530 ? 130.415 156.179 182.401 1.00 59.10  ? 556 LEU A O   1 
ATOM   4073 C CB  . LEU A 1 530 ? 131.044 153.193 181.308 1.00 46.87  ? 556 LEU A CB  1 
ATOM   4074 C CG  . LEU A 1 530 ? 131.875 151.966 181.685 1.00 51.80  ? 556 LEU A CG  1 
ATOM   4075 C CD1 . LEU A 1 530 ? 132.653 151.445 180.488 1.00 54.37  ? 556 LEU A CD1 1 
ATOM   4076 C CD2 . LEU A 1 530 ? 132.816 152.291 182.832 1.00 53.22  ? 556 LEU A CD2 1 
ATOM   4077 N N   . GLN A 1 531 ? 128.673 155.337 181.265 1.00 65.03  ? 557 GLN A N   1 
ATOM   4078 C CA  . GLN A 1 531 ? 128.186 156.654 180.878 1.00 61.32  ? 557 GLN A CA  1 
ATOM   4079 C C   . GLN A 1 531 ? 126.689 156.584 180.626 1.00 65.08  ? 557 GLN A C   1 
ATOM   4080 O O   . GLN A 1 531 ? 126.204 155.631 180.014 1.00 71.96  ? 557 GLN A O   1 
ATOM   4081 C CB  . GLN A 1 531 ? 128.913 157.173 179.633 1.00 61.02  ? 557 GLN A CB  1 
ATOM   4082 C CG  . GLN A 1 531 ? 128.457 158.545 179.170 1.00 67.28  ? 557 GLN A CG  1 
ATOM   4083 C CD  . GLN A 1 531 ? 129.287 159.074 178.018 1.00 72.67  ? 557 GLN A CD  1 
ATOM   4084 O OE1 . GLN A 1 531 ? 130.388 158.589 177.755 1.00 72.77  ? 557 GLN A OE1 1 
ATOM   4085 N NE2 . GLN A 1 531 ? 128.762 160.075 177.321 1.00 69.23  ? 557 GLN A NE2 1 
ATOM   4086 N N   . GLY A 1 532 ? 125.964 157.587 181.100 1.00 56.53  ? 558 GLY A N   1 
ATOM   4087 C CA  . GLY A 1 532 ? 124.534 157.655 180.893 1.00 56.33  ? 558 GLY A CA  1 
ATOM   4088 C C   . GLY A 1 532 ? 123.735 157.221 182.105 1.00 57.81  ? 558 GLY A C   1 
ATOM   4089 O O   . GLY A 1 532 ? 124.195 157.260 183.248 1.00 64.10  ? 558 GLY A O   1 
ATOM   4090 N N   . GLU A 1 533 ? 122.500 156.800 181.836 1.00 58.70  ? 559 GLU A N   1 
ATOM   4091 C CA  . GLU A 1 533 ? 121.575 156.368 182.878 1.00 60.57  ? 559 GLU A CA  1 
ATOM   4092 C C   . GLU A 1 533 ? 120.803 155.158 182.382 1.00 64.99  ? 559 GLU A C   1 
ATOM   4093 O O   . GLU A 1 533 ? 120.179 155.212 181.318 1.00 65.16  ? 559 GLU A O   1 
ATOM   4094 C CB  . GLU A 1 533 ? 120.611 157.492 183.264 1.00 58.25  ? 559 GLU A CB  1 
ATOM   4095 C CG  . GLU A 1 533 ? 119.522 157.063 184.231 1.00 63.87  ? 559 GLU A CG  1 
ATOM   4096 C CD  . GLU A 1 533 ? 118.499 158.152 184.478 1.00 69.97  ? 559 GLU A CD  1 
ATOM   4097 O OE1 . GLU A 1 533 ? 118.653 159.253 183.911 1.00 72.13  ? 559 GLU A OE1 1 
ATOM   4098 O OE2 . GLU A 1 533 ? 117.539 157.906 185.238 1.00 67.98  ? 559 GLU A OE2 1 
ATOM   4099 N N   . VAL A 1 534 ? 120.843 154.070 183.152 1.00 57.36  ? 560 VAL A N   1 
ATOM   4100 C CA  . VAL A 1 534 ? 120.129 152.844 182.825 1.00 51.27  ? 560 VAL A CA  1 
ATOM   4101 C C   . VAL A 1 534 ? 119.326 152.401 184.040 1.00 55.81  ? 560 VAL A C   1 
ATOM   4102 O O   . VAL A 1 534 ? 119.573 152.827 185.170 1.00 65.45  ? 560 VAL A O   1 
ATOM   4103 C CB  . VAL A 1 534 ? 121.077 151.715 182.369 1.00 50.57  ? 560 VAL A CB  1 
ATOM   4104 C CG1 . VAL A 1 534 ? 121.791 152.104 181.088 1.00 55.50  ? 560 VAL A CG1 1 
ATOM   4105 C CG2 . VAL A 1 534 ? 122.078 151.392 183.462 1.00 53.25  ? 560 VAL A CG2 1 
ATOM   4106 N N   . THR A 1 535 ? 118.334 151.552 183.786 1.00 48.47  ? 561 THR A N   1 
ATOM   4107 C CA  . THR A 1 535 ? 117.547 150.920 184.837 1.00 46.22  ? 561 THR A CA  1 
ATOM   4108 C C   . THR A 1 535 ? 117.592 149.412 184.643 1.00 48.69  ? 561 THR A C   1 
ATOM   4109 O O   . THR A 1 535 ? 117.256 148.911 183.565 1.00 55.59  ? 561 THR A O   1 
ATOM   4110 C CB  . THR A 1 535 ? 116.097 151.410 184.834 1.00 47.01  ? 561 THR A CB  1 
ATOM   4111 O OG1 . THR A 1 535 ? 115.476 151.065 183.591 1.00 55.76  ? 561 THR A OG1 1 
ATOM   4112 C CG2 . THR A 1 535 ? 116.041 152.915 185.019 1.00 49.61  ? 561 THR A CG2 1 
ATOM   4113 N N   . VAL A 1 536 ? 118.004 148.695 185.683 1.00 43.61  ? 562 VAL A N   1 
ATOM   4114 C CA  . VAL A 1 536 ? 118.138 147.245 185.634 1.00 41.29  ? 562 VAL A CA  1 
ATOM   4115 C C   . VAL A 1 536 ? 116.980 146.630 186.402 1.00 48.85  ? 562 VAL A C   1 
ATOM   4116 O O   . VAL A 1 536 ? 116.762 146.954 187.577 1.00 57.72  ? 562 VAL A O   1 
ATOM   4117 C CB  . VAL A 1 536 ? 119.487 146.788 186.210 1.00 47.18  ? 562 VAL A CB  1 
ATOM   4118 C CG1 . VAL A 1 536 ? 119.603 145.277 186.148 1.00 50.04  ? 562 VAL A CG1 1 
ATOM   4119 C CG2 . VAL A 1 536 ? 120.630 147.444 185.458 1.00 53.25  ? 562 VAL A CG2 1 
ATOM   4120 N N   . GLU A 1 537 ? 116.239 145.744 185.742 1.00 54.12  ? 563 GLU A N   1 
ATOM   4121 C CA  . GLU A 1 537 ? 115.047 145.124 186.300 1.00 51.03  ? 563 GLU A CA  1 
ATOM   4122 C C   . GLU A 1 537 ? 115.252 143.623 186.422 1.00 55.07  ? 563 GLU A C   1 
ATOM   4123 O O   . GLU A 1 537 ? 115.615 142.960 185.443 1.00 65.08  ? 563 GLU A O   1 
ATOM   4124 C CB  . GLU A 1 537 ? 113.820 145.408 185.432 1.00 53.60  ? 563 GLU A CB  1 
ATOM   4125 C CG  . GLU A 1 537 ? 112.622 144.534 185.760 1.00 59.93  ? 563 GLU A CG  1 
ATOM   4126 C CD  . GLU A 1 537 ? 111.479 144.712 184.780 1.00 67.06  ? 563 GLU A CD  1 
ATOM   4127 O OE1 . GLU A 1 537 ? 111.491 145.705 184.024 1.00 67.74  ? 563 GLU A OE1 1 
ATOM   4128 O OE2 . GLU A 1 537 ? 110.570 143.856 184.765 1.00 65.24  ? 563 GLU A OE2 1 
ATOM   4129 N N   . LEU A 1 538 ? 115.015 143.097 187.620 1.00 46.25  ? 564 LEU A N   1 
ATOM   4130 C CA  . LEU A 1 538 ? 114.965 141.666 187.870 1.00 46.78  ? 564 LEU A CA  1 
ATOM   4131 C C   . LEU A 1 538 ? 113.504 141.235 187.841 1.00 56.95  ? 564 LEU A C   1 
ATOM   4132 O O   . LEU A 1 538 ? 112.677 141.777 188.589 1.00 63.86  ? 564 LEU A O   1 
ATOM   4133 C CB  . LEU A 1 538 ? 115.608 141.321 189.212 1.00 46.17  ? 564 LEU A CB  1 
ATOM   4134 C CG  . LEU A 1 538 ? 117.020 141.861 189.434 1.00 53.05  ? 564 LEU A CG  1 
ATOM   4135 C CD1 . LEU A 1 538 ? 117.574 141.400 190.771 1.00 51.28  ? 564 LEU A CD1 1 
ATOM   4136 C CD2 . LEU A 1 538 ? 117.937 141.443 188.297 1.00 54.91  ? 564 LEU A CD2 1 
ATOM   4137 N N   . VAL A 1 539 ? 113.192 140.272 186.966 1.00 49.35  ? 565 VAL A N   1 
ATOM   4138 C CA  . VAL A 1 539 ? 111.811 139.851 186.740 1.00 43.61  ? 565 VAL A CA  1 
ATOM   4139 C C   . VAL A 1 539 ? 111.333 138.801 187.726 1.00 44.46  ? 565 VAL A C   1 
ATOM   4140 O O   . VAL A 1 539 ? 110.131 138.513 187.770 1.00 50.17  ? 565 VAL A O   1 
ATOM   4141 C CB  . VAL A 1 539 ? 111.635 139.297 185.314 1.00 41.62  ? 565 VAL A CB  1 
ATOM   4142 C CG1 . VAL A 1 539 ? 112.213 140.261 184.294 1.00 42.28  ? 565 VAL A CG1 1 
ATOM   4143 C CG2 . VAL A 1 539 ? 112.286 137.929 185.193 1.00 44.54  ? 565 VAL A CG2 1 
ATOM   4144 N N   . ALA A 1 540 ? 112.235 138.210 188.511 1.00 50.52  ? 566 ALA A N   1 
ATOM   4145 C CA  . ALA A 1 540 ? 111.809 137.223 189.497 1.00 53.52  ? 566 ALA A CA  1 
ATOM   4146 C C   . ALA A 1 540 ? 110.960 137.865 190.586 1.00 55.05  ? 566 ALA A C   1 
ATOM   4147 O O   . ALA A 1 540 ? 109.931 137.310 190.988 1.00 59.50  ? 566 ALA A O   1 
ATOM   4148 C CB  . ALA A 1 540 ? 113.027 136.526 190.102 1.00 53.82  ? 566 ALA A CB  1 
ATOM   4149 N N   . GLU A 1 541 ? 111.369 139.038 191.071 1.00 55.21  ? 567 GLU A N   1 
ATOM   4150 C CA  . GLU A 1 541 ? 110.608 139.775 192.071 1.00 54.04  ? 567 GLU A CA  1 
ATOM   4151 C C   . GLU A 1 541 ? 110.082 141.101 191.541 1.00 60.28  ? 567 GLU A C   1 
ATOM   4152 O O   . GLU A 1 541 ? 109.508 141.878 192.313 1.00 64.12  ? 567 GLU A O   1 
ATOM   4153 C CB  . GLU A 1 541 ? 111.454 140.012 193.327 1.00 57.19  ? 567 GLU A CB  1 
ATOM   4154 C CG  . GLU A 1 541 ? 112.802 140.666 193.072 1.00 62.61  ? 567 GLU A CG  1 
ATOM   4155 C CD  . GLU A 1 541 ? 113.889 139.659 192.751 1.00 68.26  ? 567 GLU A CD  1 
ATOM   4156 O OE1 . GLU A 1 541 ? 113.587 138.448 192.715 1.00 67.77  ? 567 GLU A OE1 1 
ATOM   4157 O OE2 . GLU A 1 541 ? 115.046 140.078 192.539 1.00 70.95  ? 567 GLU A OE2 1 
ATOM   4158 N N   . GLN A 1 542 ? 110.266 141.380 190.248 1.00 57.51  ? 568 GLN A N   1 
ATOM   4159 C CA  . GLN A 1 542 ? 109.768 142.603 189.617 1.00 55.22  ? 568 GLN A CA  1 
ATOM   4160 C C   . GLN A 1 542 ? 110.334 143.845 190.304 1.00 57.16  ? 568 GLN A C   1 
ATOM   4161 O O   . GLN A 1 542 ? 109.598 144.740 190.725 1.00 57.03  ? 568 GLN A O   1 
ATOM   4162 C CB  . GLN A 1 542 ? 108.236 142.635 189.606 1.00 53.15  ? 568 GLN A CB  1 
ATOM   4163 C CG  . GLN A 1 542 ? 107.584 141.491 188.849 1.00 56.33  ? 568 GLN A CG  1 
ATOM   4164 C CD  . GLN A 1 542 ? 107.673 141.658 187.346 1.00 62.11  ? 568 GLN A CD  1 
ATOM   4165 O OE1 . GLN A 1 542 ? 108.039 142.722 186.849 1.00 60.45  ? 568 GLN A OE1 1 
ATOM   4166 N NE2 . GLN A 1 542 ? 107.336 140.603 186.613 1.00 61.49  ? 568 GLN A NE2 1 
ATOM   4167 N N   . LYS A 1 543 ? 111.658 143.895 190.420 1.00 60.58  ? 569 LYS A N   1 
ATOM   4168 C CA  . LYS A 1 543 ? 112.333 144.981 191.121 1.00 54.27  ? 569 LYS A CA  1 
ATOM   4169 C C   . LYS A 1 543 ? 113.361 145.623 190.204 1.00 58.89  ? 569 LYS A C   1 
ATOM   4170 O O   . LYS A 1 543 ? 114.237 144.934 189.675 1.00 68.90  ? 569 LYS A O   1 
ATOM   4171 C CB  . LYS A 1 543 ? 113.009 144.472 192.396 1.00 57.71  ? 569 LYS A CB  1 
ATOM   4172 C CG  . LYS A 1 543 ? 113.789 145.533 193.152 1.00 61.10  ? 569 LYS A CG  1 
ATOM   4173 C CD  . LYS A 1 543 ? 114.509 144.939 194.352 1.00 64.25  ? 569 LYS A CD  1 
ATOM   4174 C CE  . LYS A 1 543 ? 113.532 144.289 195.320 1.00 66.57  ? 569 LYS A CE  1 
ATOM   4175 N NZ  . LYS A 1 543 ? 114.225 143.702 196.500 1.00 62.78  ? 569 LYS A NZ  1 
ATOM   4176 N N   . ASN A 1 544 ? 113.269 146.942 190.011 1.00 53.74  ? 570 ASN A N   1 
ATOM   4177 C CA  . ASN A 1 544 ? 114.188 147.670 189.148 1.00 55.89  ? 570 ASN A CA  1 
ATOM   4178 C C   . ASN A 1 544 ? 114.911 148.758 189.929 1.00 55.61  ? 570 ASN A C   1 
ATOM   4179 O O   . ASN A 1 544 ? 114.313 149.445 190.762 1.00 59.22  ? 570 ASN A O   1 
ATOM   4180 C CB  . ASN A 1 544 ? 113.464 148.278 187.936 1.00 55.72  ? 570 ASN A CB  1 
ATOM   4181 C CG  . ASN A 1 544 ? 112.293 149.153 188.324 1.00 59.40  ? 570 ASN A CG  1 
ATOM   4182 O OD1 . ASN A 1 544 ? 112.110 149.489 189.494 1.00 63.31  ? 570 ASN A OD1 1 
ATOM   4183 N ND2 . ASN A 1 544 ? 111.486 149.530 187.336 1.00 59.46  ? 570 ASN A ND2 1 
ATOM   4184 N N   . GLN A 1 545 ? 116.197 148.893 189.660 1.00 64.91  ? 571 GLN A N   1 
ATOM   4185 C CA  . GLN A 1 545 ? 117.042 149.919 190.254 1.00 63.42  ? 571 GLN A CA  1 
ATOM   4186 C C   . GLN A 1 545 ? 117.636 150.794 189.161 1.00 65.90  ? 571 GLN A C   1 
ATOM   4187 O O   . GLN A 1 545 ? 118.072 150.293 188.118 1.00 74.17  ? 571 GLN A O   1 
ATOM   4188 C CB  . GLN A 1 545 ? 118.172 149.309 191.085 1.00 62.30  ? 571 GLN A CB  1 
ATOM   4189 C CG  . GLN A 1 545 ? 117.734 148.708 192.405 1.00 70.77  ? 571 GLN A CG  1 
ATOM   4190 C CD  . GLN A 1 545 ? 118.912 148.328 193.278 1.00 73.65  ? 571 GLN A CD  1 
ATOM   4191 O OE1 . GLN A 1 545 ? 120.067 148.517 192.896 1.00 71.43  ? 571 GLN A OE1 1 
ATOM   4192 N NE2 . GLN A 1 545 ? 118.627 147.790 194.458 1.00 71.60  ? 571 GLN A NE2 1 
ATOM   4193 N N   . THR A 1 546 ? 117.652 152.102 189.404 1.00 59.41  ? 572 THR A N   1 
ATOM   4194 C CA  . THR A 1 546 ? 118.225 153.061 188.470 1.00 60.26  ? 572 THR A CA  1 
ATOM   4195 C C   . THR A 1 546 ? 119.694 153.274 188.815 1.00 62.27  ? 572 THR A C   1 
ATOM   4196 O O   . THR A 1 546 ? 120.016 153.741 189.913 1.00 65.61  ? 572 THR A O   1 
ATOM   4197 C CB  . THR A 1 546 ? 117.467 154.386 188.521 1.00 61.20  ? 572 THR A CB  1 
ATOM   4198 O OG1 . THR A 1 546 ? 117.776 155.065 189.744 1.00 64.87  ? 572 THR A OG1 1 
ATOM   4199 C CG2 . THR A 1 546 ? 115.969 154.140 188.457 1.00 62.16  ? 572 THR A CG2 1 
ATOM   4200 N N   . LEU A 1 547 ? 120.579 152.939 187.882 1.00 60.61  ? 573 LEU A N   1 
ATOM   4201 C CA  . LEU A 1 547 ? 122.014 153.018 188.102 1.00 62.14  ? 573 LEU A CA  1 
ATOM   4202 C C   . LEU A 1 547 ? 122.568 154.315 187.529 1.00 66.61  ? 573 LEU A C   1 
ATOM   4203 O O   . LEU A 1 547 ? 122.170 154.748 186.444 1.00 66.36  ? 573 LEU A O   1 
ATOM   4204 C CB  . LEU A 1 547 ? 122.732 151.821 187.470 1.00 63.01  ? 573 LEU A CB  1 
ATOM   4205 C CG  . LEU A 1 547 ? 122.788 150.507 188.257 1.00 60.78  ? 573 LEU A CG  1 
ATOM   4206 C CD1 . LEU A 1 547 ? 121.415 149.879 188.412 1.00 60.84  ? 573 LEU A CD1 1 
ATOM   4207 C CD2 . LEU A 1 547 ? 123.742 149.531 187.593 1.00 60.69  ? 573 LEU A CD2 1 
ATOM   4208 N N   . ARG A 1 548 ? 123.481 154.934 188.271 1.00 83.10  ? 574 ARG A N   1 
ATOM   4209 C CA  . ARG A 1 548 ? 124.208 156.110 187.823 1.00 79.81  ? 574 ARG A CA  1 
ATOM   4210 C C   . ARG A 1 548 ? 125.621 155.710 187.404 1.00 81.69  ? 574 ARG A C   1 
ATOM   4211 O O   . ARG A 1 548 ? 125.980 154.530 187.381 1.00 86.63  ? 574 ARG A O   1 
ATOM   4212 C CB  . ARG A 1 548 ? 124.235 157.178 188.917 1.00 77.42  ? 574 ARG A CB  1 
ATOM   4213 C CG  . ARG A 1 548 ? 123.255 158.319 188.697 1.00 80.67  ? 574 ARG A CG  1 
ATOM   4214 C CD  . ARG A 1 548 ? 121.821 157.825 188.648 1.00 83.38  ? 574 ARG A CD  1 
ATOM   4215 N NE  . ARG A 1 548 ? 120.878 158.918 188.448 1.00 85.27  ? 574 ARG A NE  1 
ATOM   4216 C CZ  . ARG A 1 548 ? 120.337 159.630 189.427 1.00 86.64  ? 574 ARG A CZ  1 
ATOM   4217 N NH1 . ARG A 1 548 ? 120.623 159.389 190.696 1.00 85.53  ? 574 ARG A NH1 1 
ATOM   4218 N NH2 . ARG A 1 548 ? 119.487 160.608 189.125 1.00 84.43  ? 574 ARG A NH2 1 
ATOM   4219 N N   . GLU A 1 549 ? 126.431 156.708 187.063 1.00 72.13  ? 575 GLU A N   1 
ATOM   4220 C CA  . GLU A 1 549 ? 127.784 156.441 186.594 1.00 72.73  ? 575 GLU A CA  1 
ATOM   4221 C C   . GLU A 1 549 ? 128.639 155.886 187.726 1.00 71.84  ? 575 GLU A C   1 
ATOM   4222 O O   . GLU A 1 549 ? 128.692 156.458 188.818 1.00 72.90  ? 575 GLU A O   1 
ATOM   4223 C CB  . GLU A 1 549 ? 128.415 157.715 186.037 1.00 73.03  ? 575 GLU A CB  1 
ATOM   4224 C CG  . GLU A 1 549 ? 127.658 158.329 184.874 1.00 76.10  ? 575 GLU A CG  1 
ATOM   4225 C CD  . GLU A 1 549 ? 128.354 159.552 184.311 1.00 81.35  ? 575 GLU A CD  1 
ATOM   4226 O OE1 . GLU A 1 549 ? 129.500 159.827 184.725 1.00 79.82  ? 575 GLU A OE1 1 
ATOM   4227 O OE2 . GLU A 1 549 ? 127.756 160.239 183.456 1.00 81.97  ? 575 GLU A OE2 1 
ATOM   4228 N N   . GLY A 1 550 ? 129.307 154.764 187.461 1.00 70.39  ? 576 GLY A N   1 
ATOM   4229 C CA  . GLY A 1 550 ? 130.183 154.136 188.421 1.00 70.84  ? 576 GLY A CA  1 
ATOM   4230 C C   . GLY A 1 550 ? 129.536 153.072 189.281 1.00 74.24  ? 576 GLY A C   1 
ATOM   4231 O O   . GLY A 1 550 ? 130.253 152.278 189.900 1.00 77.68  ? 576 GLY A O   1 
ATOM   4232 N N   . GLU A 1 551 ? 128.209 153.030 189.340 1.00 69.56  ? 577 GLU A N   1 
ATOM   4233 C CA  . GLU A 1 551 ? 127.529 152.064 190.188 1.00 66.77  ? 577 GLU A CA  1 
ATOM   4234 C C   . GLU A 1 551 ? 127.671 150.654 189.626 1.00 71.93  ? 577 GLU A C   1 
ATOM   4235 O O   . GLU A 1 551 ? 127.722 150.445 188.411 1.00 77.25  ? 577 GLU A O   1 
ATOM   4236 C CB  . GLU A 1 551 ? 126.054 152.431 190.337 1.00 70.21  ? 577 GLU A CB  1 
ATOM   4237 C CG  . GLU A 1 551 ? 125.829 153.802 190.955 1.00 74.77  ? 577 GLU A CG  1 
ATOM   4238 C CD  . GLU A 1 551 ? 124.367 154.097 191.215 1.00 78.47  ? 577 GLU A CD  1 
ATOM   4239 O OE1 . GLU A 1 551 ? 123.535 153.180 191.050 1.00 81.38  ? 577 GLU A OE1 1 
ATOM   4240 O OE2 . GLU A 1 551 ? 124.048 155.247 191.583 1.00 75.48  ? 577 GLU A OE2 1 
ATOM   4241 N N   . LYS A 1 552 ? 127.733 149.682 190.531 1.00 55.37  ? 578 LYS A N   1 
ATOM   4242 C CA  . LYS A 1 552 ? 127.970 148.288 190.186 1.00 51.68  ? 578 LYS A CA  1 
ATOM   4243 C C   . LYS A 1 552 ? 126.904 147.418 190.833 1.00 53.16  ? 578 LYS A C   1 
ATOM   4244 O O   . LYS A 1 552 ? 126.529 147.641 191.988 1.00 62.00  ? 578 LYS A O   1 
ATOM   4245 C CB  . LYS A 1 552 ? 129.367 147.850 190.640 1.00 53.73  ? 578 LYS A CB  1 
ATOM   4246 C CG  . LYS A 1 552 ? 129.736 146.424 190.283 1.00 55.51  ? 578 LYS A CG  1 
ATOM   4247 C CD  . LYS A 1 552 ? 131.125 146.081 190.800 1.00 57.36  ? 578 LYS A CD  1 
ATOM   4248 C CE  . LYS A 1 552 ? 131.514 144.657 190.439 1.00 58.49  ? 578 LYS A CE  1 
ATOM   4249 N NZ  . LYS A 1 552 ? 132.878 144.311 190.923 1.00 58.28  ? 578 LYS A NZ  1 
ATOM   4250 N N   . MET A 1 553 ? 126.415 146.431 190.086 1.00 51.38  ? 579 MET A N   1 
ATOM   4251 C CA  . MET A 1 553 ? 125.377 145.530 190.566 1.00 47.68  ? 579 MET A CA  1 
ATOM   4252 C C   . MET A 1 553 ? 125.783 144.090 190.292 1.00 51.62  ? 579 MET A C   1 
ATOM   4253 O O   . MET A 1 553 ? 126.500 143.806 189.330 1.00 59.11  ? 579 MET A O   1 
ATOM   4254 C CB  . MET A 1 553 ? 124.026 145.833 189.903 1.00 53.45  ? 579 MET A CB  1 
ATOM   4255 C CG  . MET A 1 553 ? 122.841 145.122 190.533 1.00 56.31  ? 579 MET A CG  1 
ATOM   4256 S SD  . MET A 1 553 ? 121.291 145.439 189.675 1.00 66.74  ? 579 MET A SD  1 
ATOM   4257 C CE  . MET A 1 553 ? 120.147 144.520 190.700 1.00 54.05  ? 579 MET A CE  1 
ATOM   4258 N N   . GLN A 1 554 ? 125.313 143.181 191.142 1.00 41.50  ? 580 GLN A N   1 
ATOM   4259 C CA  . GLN A 1 554 ? 125.608 141.754 191.033 1.00 44.10  ? 580 GLN A CA  1 
ATOM   4260 C C   . GLN A 1 554 ? 124.334 141.051 190.575 1.00 50.83  ? 580 GLN A C   1 
ATOM   4261 O O   . GLN A 1 554 ? 123.398 140.873 191.360 1.00 51.03  ? 580 GLN A O   1 
ATOM   4262 C CB  . GLN A 1 554 ? 126.104 141.201 192.365 1.00 46.75  ? 580 GLN A CB  1 
ATOM   4263 C CG  . GLN A 1 554 ? 126.775 139.843 192.273 1.00 49.83  ? 580 GLN A CG  1 
ATOM   4264 C CD  . GLN A 1 554 ? 128.259 139.946 191.993 1.00 50.04  ? 580 GLN A CD  1 
ATOM   4265 O OE1 . GLN A 1 554 ? 128.849 141.021 192.098 1.00 47.47  ? 580 GLN A OE1 1 
ATOM   4266 N NE2 . GLN A 1 554 ? 128.873 138.825 191.637 1.00 49.42  ? 580 GLN A NE2 1 
ATOM   4267 N N   . LEU A 1 555 ? 124.299 140.647 189.302 1.00 54.06  ? 581 LEU A N   1 
ATOM   4268 C CA  . LEU A 1 555 ? 123.077 140.091 188.744 1.00 44.93  ? 581 LEU A CA  1 
ATOM   4269 C C   . LEU A 1 555 ? 122.910 138.624 189.138 1.00 47.60  ? 581 LEU A C   1 
ATOM   4270 O O   . LEU A 1 555 ? 123.895 137.911 189.343 1.00 55.50  ? 581 LEU A O   1 
ATOM   4271 C CB  . LEU A 1 555 ? 123.082 140.217 187.227 1.00 38.09  ? 581 LEU A CB  1 
ATOM   4272 C CG  . LEU A 1 555 ? 123.074 141.643 186.680 1.00 44.33  ? 581 LEU A CG  1 
ATOM   4273 C CD1 . LEU A 1 555 ? 123.127 141.632 185.164 1.00 52.33  ? 581 LEU A CD1 1 
ATOM   4274 C CD2 . LEU A 1 555 ? 121.846 142.389 187.168 1.00 47.38  ? 581 LEU A CD2 1 
ATOM   4275 N N   . PRO A 1 556 ? 121.669 138.155 189.249 1.00 41.73  ? 582 PRO A N   1 
ATOM   4276 C CA  . PRO A 1 556 ? 121.441 136.743 189.572 1.00 40.36  ? 582 PRO A CA  1 
ATOM   4277 C C   . PRO A 1 556 ? 121.852 135.832 188.428 1.00 46.65  ? 582 PRO A C   1 
ATOM   4278 O O   . PRO A 1 556 ? 121.856 136.222 187.259 1.00 58.58  ? 582 PRO A O   1 
ATOM   4279 C CB  . PRO A 1 556 ? 119.929 136.673 189.816 1.00 41.74  ? 582 PRO A CB  1 
ATOM   4280 C CG  . PRO A 1 556 ? 119.510 138.081 190.076 1.00 48.13  ? 582 PRO A CG  1 
ATOM   4281 C CD  . PRO A 1 556 ? 120.416 138.924 189.241 1.00 50.49  ? 582 PRO A CD  1 
ATOM   4282 N N   . ALA A 1 557 ? 122.202 134.599 188.783 1.00 37.52  ? 583 ALA A N   1 
ATOM   4283 C CA  . ALA A 1 557 ? 122.565 133.577 187.814 1.00 40.02  ? 583 ALA A CA  1 
ATOM   4284 C C   . ALA A 1 557 ? 121.420 132.584 187.671 1.00 46.35  ? 583 ALA A C   1 
ATOM   4285 O O   . ALA A 1 557 ? 120.947 132.028 188.667 1.00 50.42  ? 583 ALA A O   1 
ATOM   4286 C CB  . ALA A 1 557 ? 123.844 132.853 188.236 1.00 43.51  ? 583 ALA A CB  1 
ATOM   4287 N N   . GLY A 1 558 ? 120.981 132.367 186.436 1.00 46.04  ? 584 GLY A N   1 
ATOM   4288 C CA  . GLY A 1 558 ? 119.889 131.462 186.157 1.00 43.16  ? 584 GLY A CA  1 
ATOM   4289 C C   . GLY A 1 558 ? 118.527 132.100 186.004 1.00 49.83  ? 584 GLY A C   1 
ATOM   4290 O O   . GLY A 1 558 ? 117.531 131.372 185.926 1.00 54.32  ? 584 GLY A O   1 
ATOM   4291 N N   . GLU A 1 559 ? 118.446 133.428 185.956 1.00 54.84  ? 585 GLU A N   1 
ATOM   4292 C CA  . GLU A 1 559 ? 117.182 134.144 185.852 1.00 49.79  ? 585 GLU A CA  1 
ATOM   4293 C C   . GLU A 1 559 ? 117.261 135.155 184.712 1.00 50.52  ? 585 GLU A C   1 
ATOM   4294 O O   . GLU A 1 559 ? 118.308 135.346 184.088 1.00 52.52  ? 585 GLU A O   1 
ATOM   4295 C CB  . GLU A 1 559 ? 116.830 134.841 187.172 1.00 45.99  ? 585 GLU A CB  1 
ATOM   4296 C CG  . GLU A 1 559 ? 116.730 133.904 188.363 1.00 53.28  ? 585 GLU A CG  1 
ATOM   4297 C CD  . GLU A 1 559 ? 116.434 134.637 189.657 1.00 64.61  ? 585 GLU A CD  1 
ATOM   4298 O OE1 . GLU A 1 559 ? 116.293 135.877 189.619 1.00 63.10  ? 585 GLU A OE1 1 
ATOM   4299 O OE2 . GLU A 1 559 ? 116.345 133.974 190.712 1.00 65.97  ? 585 GLU A OE2 1 
ATOM   4300 N N   . TYR A 1 560 ? 116.134 135.807 184.442 1.00 44.20  ? 586 TYR A N   1 
ATOM   4301 C CA  . TYR A 1 560 ? 116.029 136.813 183.395 1.00 43.64  ? 586 TYR A CA  1 
ATOM   4302 C C   . TYR A 1 560 ? 116.187 138.203 183.996 1.00 48.80  ? 586 TYR A C   1 
ATOM   4303 O O   . TYR A 1 560 ? 115.691 138.475 185.093 1.00 57.89  ? 586 TYR A O   1 
ATOM   4304 C CB  . TYR A 1 560 ? 114.680 136.724 182.676 1.00 45.51  ? 586 TYR A CB  1 
ATOM   4305 C CG  . TYR A 1 560 ? 114.418 135.423 181.954 1.00 42.51  ? 586 TYR A CG  1 
ATOM   4306 C CD1 . TYR A 1 560 ? 114.024 134.287 182.647 1.00 49.98  ? 586 TYR A CD1 1 
ATOM   4307 C CD2 . TYR A 1 560 ? 114.538 135.337 180.575 1.00 39.21  ? 586 TYR A CD2 1 
ATOM   4308 C CE1 . TYR A 1 560 ? 113.776 133.100 181.989 1.00 49.45  ? 586 TYR A CE1 1 
ATOM   4309 C CE2 . TYR A 1 560 ? 114.292 134.155 179.910 1.00 44.96  ? 586 TYR A CE2 1 
ATOM   4310 C CZ  . TYR A 1 560 ? 113.912 133.040 180.621 1.00 49.85  ? 586 TYR A CZ  1 
ATOM   4311 O OH  . TYR A 1 560 ? 113.665 131.860 179.959 1.00 53.90  ? 586 TYR A OH  1 
ATOM   4312 N N   . HIS A 1 561 ? 116.880 139.081 183.275 1.00 39.33  ? 587 HIS A N   1 
ATOM   4313 C CA  . HIS A 1 561 ? 116.979 140.476 183.677 1.00 37.27  ? 587 HIS A CA  1 
ATOM   4314 C C   . HIS A 1 561 ? 116.860 141.363 182.447 1.00 43.25  ? 587 HIS A C   1 
ATOM   4315 O O   . HIS A 1 561 ? 117.021 140.913 181.308 1.00 54.81  ? 587 HIS A O   1 
ATOM   4316 C CB  . HIS A 1 561 ? 118.279 140.766 184.443 1.00 37.44  ? 587 HIS A CB  1 
ATOM   4317 C CG  . HIS A 1 561 ? 119.505 140.799 183.586 1.00 36.59  ? 587 HIS A CG  1 
ATOM   4318 N ND1 . HIS A 1 561 ? 120.285 139.686 183.359 1.00 40.56  ? 587 HIS A ND1 1 
ATOM   4319 C CD2 . HIS A 1 561 ? 120.104 141.817 182.925 1.00 40.66  ? 587 HIS A CD2 1 
ATOM   4320 C CE1 . HIS A 1 561 ? 121.302 140.014 182.584 1.00 42.55  ? 587 HIS A CE1 1 
ATOM   4321 N NE2 . HIS A 1 561 ? 121.215 141.301 182.305 1.00 43.34  ? 587 HIS A NE2 1 
ATOM   4322 N N   . LYS A 1 562 ? 116.533 142.630 182.688 1.00 43.02  ? 588 LYS A N   1 
ATOM   4323 C CA  . LYS A 1 562 ? 116.351 143.600 181.621 1.00 39.05  ? 588 LYS A CA  1 
ATOM   4324 C C   . LYS A 1 562 ? 117.130 144.869 181.930 1.00 43.28  ? 588 LYS A C   1 
ATOM   4325 O O   . LYS A 1 562 ? 117.249 145.279 183.087 1.00 55.14  ? 588 LYS A O   1 
ATOM   4326 C CB  . LYS A 1 562 ? 114.873 143.945 181.419 1.00 45.47  ? 588 LYS A CB  1 
ATOM   4327 C CG  . LYS A 1 562 ? 114.029 142.804 180.889 1.00 49.05  ? 588 LYS A CG  1 
ATOM   4328 C CD  . LYS A 1 562 ? 112.602 143.256 180.637 1.00 51.01  ? 588 LYS A CD  1 
ATOM   4329 C CE  . LYS A 1 562 ? 111.756 142.125 180.083 1.00 50.07  ? 588 LYS A CE  1 
ATOM   4330 N NZ  . LYS A 1 562 ? 110.356 142.557 179.825 1.00 50.32  ? 588 LYS A NZ  1 
ATOM   4331 N N   . VAL A 1 563 ? 117.661 145.485 180.880 1.00 41.53  ? 589 VAL A N   1 
ATOM   4332 C CA  . VAL A 1 563 ? 118.334 146.776 180.968 1.00 40.54  ? 589 VAL A CA  1 
ATOM   4333 C C   . VAL A 1 563 ? 117.587 147.753 180.073 1.00 49.47  ? 589 VAL A C   1 
ATOM   4334 O O   . VAL A 1 563 ? 117.565 147.584 178.847 1.00 56.15  ? 589 VAL A O   1 
ATOM   4335 C CB  . VAL A 1 563 ? 119.813 146.683 180.565 1.00 40.16  ? 589 VAL A CB  1 
ATOM   4336 C CG1 . VAL A 1 563 ? 120.700 146.837 181.782 1.00 45.24  ? 589 VAL A CG1 1 
ATOM   4337 C CG2 . VAL A 1 563 ? 120.093 145.362 179.875 1.00 50.23  ? 589 VAL A CG2 1 
ATOM   4338 N N   . TYR A 1 564 ? 116.964 148.757 180.684 1.00 45.47  ? 590 TYR A N   1 
ATOM   4339 C CA  . TYR A 1 564 ? 116.281 149.821 179.964 1.00 38.07  ? 590 TYR A CA  1 
ATOM   4340 C C   . TYR A 1 564 ? 117.163 151.061 179.937 1.00 50.72  ? 590 TYR A C   1 
ATOM   4341 O O   . TYR A 1 564 ? 117.830 151.381 180.926 1.00 59.77  ? 590 TYR A O   1 
ATOM   4342 C CB  . TYR A 1 564 ? 114.944 150.172 180.619 1.00 40.32  ? 590 TYR A CB  1 
ATOM   4343 C CG  . TYR A 1 564 ? 113.899 149.083 180.605 1.00 39.92  ? 590 TYR A CG  1 
ATOM   4344 C CD1 . TYR A 1 564 ? 113.864 148.115 181.595 1.00 43.51  ? 590 TYR A CD1 1 
ATOM   4345 C CD2 . TYR A 1 564 ? 112.925 149.046 179.620 1.00 48.58  ? 590 TYR A CD2 1 
ATOM   4346 C CE1 . TYR A 1 564 ? 112.902 147.128 181.592 1.00 46.99  ? 590 TYR A CE1 1 
ATOM   4347 C CE2 . TYR A 1 564 ? 111.960 148.063 179.609 1.00 49.50  ? 590 TYR A CE2 1 
ATOM   4348 C CZ  . TYR A 1 564 ? 111.953 147.107 180.597 1.00 47.88  ? 590 TYR A CZ  1 
ATOM   4349 O OH  . TYR A 1 564 ? 110.990 146.126 180.588 1.00 50.15  ? 590 TYR A OH  1 
ATOM   4350 N N   . THR A 1 565 ? 117.159 151.758 178.806 1.00 47.96  ? 591 THR A N   1 
ATOM   4351 C CA  . THR A 1 565 ? 117.852 153.032 178.671 1.00 45.59  ? 591 THR A CA  1 
ATOM   4352 C C   . THR A 1 565 ? 116.832 154.150 178.838 1.00 50.11  ? 591 THR A C   1 
ATOM   4353 O O   . THR A 1 565 ? 115.844 154.209 178.098 1.00 56.49  ? 591 THR A O   1 
ATOM   4354 C CB  . THR A 1 565 ? 118.554 153.138 177.318 1.00 44.11  ? 591 THR A CB  1 
ATOM   4355 O OG1 . THR A 1 565 ? 119.469 152.047 177.167 1.00 46.23  ? 591 THR A OG1 1 
ATOM   4356 C CG2 . THR A 1 565 ? 119.320 154.445 177.221 1.00 49.51  ? 591 THR A CG2 1 
ATOM   4357 N N   . THR A 1 566 ? 117.069 155.030 179.806 1.00 52.53  ? 592 THR A N   1 
ATOM   4358 C CA  . THR A 1 566 ? 116.135 156.096 180.153 1.00 54.44  ? 592 THR A CA  1 
ATOM   4359 C C   . THR A 1 566 ? 116.839 157.444 180.186 1.00 58.24  ? 592 THR A C   1 
ATOM   4360 O O   . THR A 1 566 ? 116.621 158.258 181.087 1.00 60.60  ? 592 THR A O   1 
ATOM   4361 C CB  . THR A 1 566 ? 115.459 155.817 181.492 1.00 55.84  ? 592 THR A CB  1 
ATOM   4362 O OG1 . THR A 1 566 ? 116.457 155.623 182.502 1.00 59.84  ? 592 THR A OG1 1 
ATOM   4363 C CG2 . THR A 1 566 ? 114.589 154.574 181.405 1.00 56.10  ? 592 THR A CG2 1 
ATOM   4364 N N   . SER A 1 567 ? 117.694 157.702 179.203 1.00 61.37  ? 593 SER A N   1 
ATOM   4365 C CA  . SER A 1 567 ? 118.405 158.965 179.105 1.00 58.52  ? 593 SER A CA  1 
ATOM   4366 C C   . SER A 1 567 ? 118.278 159.518 177.696 1.00 56.29  ? 593 SER A C   1 
ATOM   4367 O O   . SER A 1 567 ? 118.143 158.753 176.736 1.00 66.09  ? 593 SER A O   1 
ATOM   4368 C CB  . SER A 1 567 ? 119.890 158.795 179.458 1.00 63.06  ? 593 SER A CB  1 
ATOM   4369 O OG  . SER A 1 567 ? 120.520 157.883 178.577 1.00 66.60  ? 593 SER A OG  1 
ATOM   4370 N N   . PRO A 1 568 ? 118.314 160.844 177.539 1.00 53.09  ? 594 PRO A N   1 
ATOM   4371 C CA  . PRO A 1 568 ? 118.221 161.423 176.189 1.00 58.14  ? 594 PRO A CA  1 
ATOM   4372 C C   . PRO A 1 568 ? 119.388 161.060 175.288 1.00 58.58  ? 594 PRO A C   1 
ATOM   4373 O O   . PRO A 1 568 ? 119.259 161.174 174.063 1.00 61.07  ? 594 PRO A O   1 
ATOM   4374 C CB  . PRO A 1 568 ? 118.172 162.933 176.454 1.00 60.83  ? 594 PRO A CB  1 
ATOM   4375 C CG  . PRO A 1 568 ? 117.687 163.056 177.861 1.00 61.14  ? 594 PRO A CG  1 
ATOM   4376 C CD  . PRO A 1 568 ? 118.265 161.878 178.585 1.00 60.06  ? 594 PRO A CD  1 
ATOM   4377 N N   . SER A 1 569 ? 120.510 160.630 175.845 1.00 58.44  ? 595 SER A N   1 
ATOM   4378 C CA  . SER A 1 569 ? 121.694 160.264 175.089 1.00 59.76  ? 595 SER A CA  1 
ATOM   4379 C C   . SER A 1 569 ? 121.963 158.769 175.201 1.00 60.90  ? 595 SER A C   1 
ATOM   4380 O O   . SER A 1 569 ? 121.488 158.110 176.132 1.00 65.48  ? 595 SER A O   1 
ATOM   4381 C CB  . SER A 1 569 ? 122.914 161.048 175.596 1.00 64.82  ? 595 SER A CB  1 
ATOM   4382 O OG  . SER A 1 569 ? 123.150 160.791 176.969 1.00 67.26  ? 595 SER A OG  1 
ATOM   4383 N N   . PRO A 1 570 ? 122.709 158.193 174.257 1.00 46.25  ? 596 PRO A N   1 
ATOM   4384 C CA  . PRO A 1 570 ? 123.039 156.766 174.353 1.00 45.43  ? 596 PRO A CA  1 
ATOM   4385 C C   . PRO A 1 570 ? 123.830 156.462 175.616 1.00 48.89  ? 596 PRO A C   1 
ATOM   4386 O O   . PRO A 1 570 ? 124.626 157.277 176.086 1.00 48.85  ? 596 PRO A O   1 
ATOM   4387 C CB  . PRO A 1 570 ? 123.872 156.511 173.093 1.00 46.21  ? 596 PRO A CB  1 
ATOM   4388 C CG  . PRO A 1 570 ? 123.425 157.558 172.137 1.00 52.62  ? 596 PRO A CG  1 
ATOM   4389 C CD  . PRO A 1 570 ? 123.132 158.769 172.970 1.00 51.44  ? 596 PRO A CD  1 
ATOM   4390 N N   . SER A 1 571 ? 123.602 155.272 176.166 1.00 53.91  ? 597 SER A N   1 
ATOM   4391 C CA  . SER A 1 571 ? 124.215 154.858 177.420 1.00 45.61  ? 597 SER A CA  1 
ATOM   4392 C C   . SER A 1 571 ? 125.187 153.711 177.182 1.00 50.94  ? 597 SER A C   1 
ATOM   4393 O O   . SER A 1 571 ? 124.882 152.767 176.449 1.00 61.24  ? 597 SER A O   1 
ATOM   4394 C CB  . SER A 1 571 ? 123.151 154.435 178.435 1.00 49.76  ? 597 SER A CB  1 
ATOM   4395 O OG  . SER A 1 571 ? 122.389 153.345 177.948 1.00 58.12  ? 597 SER A OG  1 
ATOM   4396 N N   . CYS A 1 572 ? 126.351 153.793 177.819 1.00 46.83  ? 598 CYS A N   1 
ATOM   4397 C CA  . CYS A 1 572 ? 127.397 152.787 177.700 1.00 50.45  ? 598 CYS A CA  1 
ATOM   4398 C C   . CYS A 1 572 ? 127.608 152.108 179.046 1.00 57.85  ? 598 CYS A C   1 
ATOM   4399 O O   . CYS A 1 572 ? 127.823 152.786 180.059 1.00 65.08  ? 598 CYS A O   1 
ATOM   4400 C CB  . CYS A 1 572 ? 128.706 153.417 177.222 1.00 49.79  ? 598 CYS A CB  1 
ATOM   4401 S SG  . CYS A 1 572 ? 128.509 154.645 175.918 1.00 68.15  ? 598 CYS A SG  1 
ATOM   4402 N N   . TYR A 1 573 ? 127.566 150.776 179.045 1.00 48.39  ? 599 TYR A N   1 
ATOM   4403 C CA  . TYR A 1 573 ? 127.797 149.978 180.243 1.00 38.94  ? 599 TYR A CA  1 
ATOM   4404 C C   . TYR A 1 573 ? 128.604 148.741 179.855 1.00 46.89  ? 599 TYR A C   1 
ATOM   4405 O O   . TYR A 1 573 ? 129.018 148.578 178.702 1.00 54.86  ? 599 TYR A O   1 
ATOM   4406 C CB  . TYR A 1 573 ? 126.474 149.624 180.936 1.00 41.73  ? 599 TYR A CB  1 
ATOM   4407 C CG  . TYR A 1 573 ? 125.416 149.025 180.040 1.00 46.88  ? 599 TYR A CG  1 
ATOM   4408 C CD1 . TYR A 1 573 ? 125.392 147.664 179.775 1.00 49.27  ? 599 TYR A CD1 1 
ATOM   4409 C CD2 . TYR A 1 573 ? 124.426 149.817 179.478 1.00 49.06  ? 599 TYR A CD2 1 
ATOM   4410 C CE1 . TYR A 1 573 ? 124.420 147.113 178.964 1.00 46.21  ? 599 TYR A CE1 1 
ATOM   4411 C CE2 . TYR A 1 573 ? 123.451 149.274 178.667 1.00 45.23  ? 599 TYR A CE2 1 
ATOM   4412 C CZ  . TYR A 1 573 ? 123.454 147.922 178.414 1.00 46.70  ? 599 TYR A CZ  1 
ATOM   4413 O OH  . TYR A 1 573 ? 122.486 147.377 177.606 1.00 54.62  ? 599 TYR A OH  1 
ATOM   4414 N N   . MET A 1 574 ? 128.837 147.861 180.828 1.00 47.75  ? 600 MET A N   1 
ATOM   4415 C CA  . MET A 1 574 ? 129.720 146.723 180.627 1.00 46.22  ? 600 MET A CA  1 
ATOM   4416 C C   . MET A 1 574 ? 129.261 145.542 181.470 1.00 49.46  ? 600 MET A C   1 
ATOM   4417 O O   . MET A 1 574 ? 128.761 145.709 182.586 1.00 57.57  ? 600 MET A O   1 
ATOM   4418 C CB  . MET A 1 574 ? 131.169 147.084 180.975 1.00 47.05  ? 600 MET A CB  1 
ATOM   4419 C CG  . MET A 1 574 ? 131.329 147.702 182.354 1.00 52.85  ? 600 MET A CG  1 
ATOM   4420 S SD  . MET A 1 574 ? 132.968 148.391 182.648 1.00 66.70  ? 600 MET A SD  1 
ATOM   4421 C CE  . MET A 1 574 ? 133.972 146.915 182.595 1.00 50.42  ? 600 MET A CE  1 
ATOM   4422 N N   . TYR A 1 575 ? 129.438 144.346 180.916 1.00 40.56  ? 601 TYR A N   1 
ATOM   4423 C CA  . TYR A 1 575 ? 129.231 143.091 181.624 1.00 35.78  ? 601 TYR A CA  1 
ATOM   4424 C C   . TYR A 1 575 ? 130.584 142.483 181.961 1.00 43.36  ? 601 TYR A C   1 
ATOM   4425 O O   . TYR A 1 575 ? 131.427 142.310 181.075 1.00 54.19  ? 601 TYR A O   1 
ATOM   4426 C CB  . TYR A 1 575 ? 128.422 142.103 180.781 1.00 37.99  ? 601 TYR A CB  1 
ATOM   4427 C CG  . TYR A 1 575 ? 126.927 142.315 180.794 1.00 39.80  ? 601 TYR A CG  1 
ATOM   4428 C CD1 . TYR A 1 575 ? 126.203 142.211 181.970 1.00 44.58  ? 601 TYR A CD1 1 
ATOM   4429 C CD2 . TYR A 1 575 ? 126.236 142.585 179.623 1.00 36.96  ? 601 TYR A CD2 1 
ATOM   4430 C CE1 . TYR A 1 575 ? 124.837 142.394 181.984 1.00 42.75  ? 601 TYR A CE1 1 
ATOM   4431 C CE2 . TYR A 1 575 ? 124.870 142.768 179.628 1.00 37.27  ? 601 TYR A CE2 1 
ATOM   4432 C CZ  . TYR A 1 575 ? 124.176 142.670 180.810 1.00 41.79  ? 601 TYR A CZ  1 
ATOM   4433 O OH  . TYR A 1 575 ? 122.813 142.852 180.820 1.00 49.66  ? 601 TYR A OH  1 
ATOM   4434 N N   . VAL A 1 576 ? 130.786 142.163 183.236 1.00 36.28  ? 602 VAL A N   1 
ATOM   4435 C CA  . VAL A 1 576 ? 131.993 141.500 183.717 1.00 31.60  ? 602 VAL A CA  1 
ATOM   4436 C C   . VAL A 1 576 ? 131.569 140.177 184.336 1.00 38.37  ? 602 VAL A C   1 
ATOM   4437 O O   . VAL A 1 576 ? 130.791 140.161 185.298 1.00 49.75  ? 602 VAL A O   1 
ATOM   4438 C CB  . VAL A 1 576 ? 132.752 142.369 184.732 1.00 37.38  ? 602 VAL A CB  1 
ATOM   4439 C CG1 . VAL A 1 576 ? 133.820 141.561 185.426 1.00 42.26  ? 602 VAL A CG1 1 
ATOM   4440 C CG2 . VAL A 1 576 ? 133.365 143.572 184.041 1.00 43.65  ? 602 VAL A CG2 1 
ATOM   4441 N N   . TYR A 1 577 ? 132.074 139.068 183.793 1.00 38.27  ? 603 TYR A N   1 
ATOM   4442 C CA  . TYR A 1 577 ? 131.575 137.759 184.190 1.00 35.02  ? 603 TYR A CA  1 
ATOM   4443 C C   . TYR A 1 577 ? 132.695 136.729 184.209 1.00 37.95  ? 603 TYR A C   1 
ATOM   4444 O O   . TYR A 1 577 ? 133.720 136.873 183.538 1.00 52.88  ? 603 TYR A O   1 
ATOM   4445 C CB  . TYR A 1 577 ? 130.453 137.284 183.257 1.00 35.86  ? 603 TYR A CB  1 
ATOM   4446 C CG  . TYR A 1 577 ? 130.870 137.127 181.815 1.00 34.00  ? 603 TYR A CG  1 
ATOM   4447 C CD1 . TYR A 1 577 ? 130.866 138.211 180.950 1.00 43.34  ? 603 TYR A CD1 1 
ATOM   4448 C CD2 . TYR A 1 577 ? 131.255 135.894 181.315 1.00 37.43  ? 603 TYR A CD2 1 
ATOM   4449 C CE1 . TYR A 1 577 ? 131.242 138.071 179.632 1.00 44.95  ? 603 TYR A CE1 1 
ATOM   4450 C CE2 . TYR A 1 577 ? 131.633 135.746 179.998 1.00 42.36  ? 603 TYR A CE2 1 
ATOM   4451 C CZ  . TYR A 1 577 ? 131.625 136.837 179.161 1.00 45.39  ? 603 TYR A CZ  1 
ATOM   4452 O OH  . TYR A 1 577 ? 132.001 136.693 177.847 1.00 45.92  ? 603 TYR A OH  1 
ATOM   4453 N N   . VAL A 1 578 ? 132.472 135.678 185.000 1.00 37.42  ? 604 VAL A N   1 
ATOM   4454 C CA  . VAL A 1 578 ? 133.360 134.529 185.100 1.00 38.73  ? 604 VAL A CA  1 
ATOM   4455 C C   . VAL A 1 578 ? 132.507 133.267 185.035 1.00 43.62  ? 604 VAL A C   1 
ATOM   4456 O O   . VAL A 1 578 ? 131.314 133.280 185.342 1.00 54.40  ? 604 VAL A O   1 
ATOM   4457 C CB  . VAL A 1 578 ? 134.204 134.557 186.395 1.00 39.18  ? 604 VAL A CB  1 
ATOM   4458 C CG1 . VAL A 1 578 ? 133.351 134.217 187.602 1.00 43.04  ? 604 VAL A CG1 1 
ATOM   4459 C CG2 . VAL A 1 578 ? 135.401 133.622 186.291 1.00 45.63  ? 604 VAL A CG2 1 
ATOM   4460 N N   . ASN A 1 579 ? 133.131 132.167 184.614 1.00 47.16  ? 605 ASN A N   1 
ATOM   4461 C CA  . ASN A 1 579 ? 132.464 130.872 184.514 1.00 43.32  ? 605 ASN A CA  1 
ATOM   4462 C C   . ASN A 1 579 ? 132.843 130.044 185.737 1.00 49.95  ? 605 ASN A C   1 
ATOM   4463 O O   . ASN A 1 579 ? 133.987 129.595 185.861 1.00 60.72  ? 605 ASN A O   1 
ATOM   4464 C CB  . ASN A 1 579 ? 132.847 130.159 183.219 1.00 43.72  ? 605 ASN A CB  1 
ATOM   4465 C CG  . ASN A 1 579 ? 131.911 129.012 182.882 1.00 51.72  ? 605 ASN A CG  1 
ATOM   4466 O OD1 . ASN A 1 579 ? 131.306 128.410 183.767 1.00 55.84  ? 605 ASN A OD1 1 
ATOM   4467 N ND2 . ASN A 1 579 ? 131.788 128.704 181.593 1.00 56.35  ? 605 ASN A ND2 1 
ATOM   4468 N N   . THR A 1 580 ? 131.880 129.842 186.640 1.00 44.78  ? 606 THR A N   1 
ATOM   4469 C CA  . THR A 1 580 ? 132.167 129.156 187.896 1.00 43.94  ? 606 THR A CA  1 
ATOM   4470 C C   . THR A 1 580 ? 132.375 127.661 187.686 1.00 50.92  ? 606 THR A C   1 
ATOM   4471 O O   . THR A 1 580 ? 133.255 127.056 188.313 1.00 60.78  ? 606 THR A O   1 
ATOM   4472 C CB  . THR A 1 580 ? 131.039 129.403 188.896 1.00 46.21  ? 606 THR A CB  1 
ATOM   4473 O OG1 . THR A 1 580 ? 130.881 130.812 189.100 1.00 49.57  ? 606 THR A OG1 1 
ATOM   4474 C CG2 . THR A 1 580 ? 131.350 128.741 190.230 1.00 50.08  ? 606 THR A CG2 1 
ATOM   4475 N N   . THR A 1 581 ? 131.576 127.046 186.809 1.00 48.44  ? 607 THR A N   1 
ATOM   4476 C CA  . THR A 1 581 ? 131.708 125.613 186.567 1.00 50.81  ? 607 THR A CA  1 
ATOM   4477 C C   . THR A 1 581 ? 133.077 125.275 185.990 1.00 56.42  ? 607 THR A C   1 
ATOM   4478 O O   . THR A 1 581 ? 133.714 124.305 186.418 1.00 64.25  ? 607 THR A O   1 
ATOM   4479 C CB  . THR A 1 581 ? 130.600 125.134 185.630 1.00 48.13  ? 607 THR A CB  1 
ATOM   4480 O OG1 . THR A 1 581 ? 129.330 125.272 186.279 1.00 51.17  ? 607 THR A OG1 1 
ATOM   4481 C CG2 . THR A 1 581 ? 130.810 123.679 185.248 1.00 50.01  ? 607 THR A CG2 1 
ATOM   4482 N N   . GLU A 1 582 ? 133.552 126.075 185.034 1.00 58.34  ? 608 GLU A N   1 
ATOM   4483 C CA  . GLU A 1 582 ? 134.872 125.836 184.461 1.00 54.57  ? 608 GLU A CA  1 
ATOM   4484 C C   . GLU A 1 582 ? 135.964 126.012 185.506 1.00 55.02  ? 608 GLU A C   1 
ATOM   4485 O O   . GLU A 1 582 ? 136.930 125.243 185.535 1.00 66.97  ? 608 GLU A O   1 
ATOM   4486 C CB  . GLU A 1 582 ? 135.112 126.772 183.277 1.00 56.38  ? 608 GLU A CB  1 
ATOM   4487 C CG  . GLU A 1 582 ? 136.472 126.604 182.623 1.00 61.26  ? 608 GLU A CG  1 
ATOM   4488 C CD  . GLU A 1 582 ? 136.696 127.582 181.487 1.00 68.58  ? 608 GLU A CD  1 
ATOM   4489 O OE1 . GLU A 1 582 ? 135.769 128.358 181.175 1.00 69.72  ? 608 GLU A OE1 1 
ATOM   4490 O OE2 . GLU A 1 582 ? 137.802 127.576 180.906 1.00 68.87  ? 608 GLU A OE2 1 
ATOM   4491 N N   . LEU A 1 583 ? 135.825 127.013 186.377 1.00 44.01  ? 609 LEU A N   1 
ATOM   4492 C CA  . LEU A 1 583 ? 136.829 127.233 187.411 1.00 46.17  ? 609 LEU A CA  1 
ATOM   4493 C C   . LEU A 1 583 ? 136.889 126.058 188.378 1.00 50.70  ? 609 LEU A C   1 
ATOM   4494 O O   . LEU A 1 583 ? 137.979 125.573 188.712 1.00 60.68  ? 609 LEU A O   1 
ATOM   4495 C CB  . LEU A 1 583 ? 136.526 128.531 188.158 1.00 46.17  ? 609 LEU A CB  1 
ATOM   4496 C CG  . LEU A 1 583 ? 137.640 129.126 189.018 1.00 51.85  ? 609 LEU A CG  1 
ATOM   4497 C CD1 . LEU A 1 583 ? 138.790 129.593 188.145 1.00 53.36  ? 609 LEU A CD1 1 
ATOM   4498 C CD2 . LEU A 1 583 ? 137.109 130.269 189.865 1.00 52.71  ? 609 LEU A CD2 1 
ATOM   4499 N N   . ALA A 1 584 ? 135.728 125.572 188.822 1.00 51.26  ? 610 ALA A N   1 
ATOM   4500 C CA  . ALA A 1 584 ? 135.708 124.433 189.733 1.00 54.74  ? 610 ALA A CA  1 
ATOM   4501 C C   . ALA A 1 584 ? 136.257 123.180 189.064 1.00 58.27  ? 610 ALA A C   1 
ATOM   4502 O O   . ALA A 1 584 ? 137.015 122.420 189.681 1.00 66.38  ? 610 ALA A O   1 
ATOM   4503 C CB  . ALA A 1 584 ? 134.288 124.193 190.244 1.00 53.93  ? 610 ALA A CB  1 
ATOM   4504 N N   . LEU A 1 585 ? 135.893 122.951 187.799 1.00 56.55  ? 611 LEU A N   1 
ATOM   4505 C CA  . LEU A 1 585 ? 136.388 121.777 187.091 1.00 54.13  ? 611 LEU A CA  1 
ATOM   4506 C C   . LEU A 1 585 ? 137.898 121.841 186.909 1.00 62.06  ? 611 LEU A C   1 
ATOM   4507 O O   . LEU A 1 585 ? 138.589 120.829 187.060 1.00 71.39  ? 611 LEU A O   1 
ATOM   4508 C CB  . LEU A 1 585 ? 135.690 121.647 185.739 1.00 53.22  ? 611 LEU A CB  1 
ATOM   4509 C CG  . LEU A 1 585 ? 136.041 120.411 184.911 1.00 57.24  ? 611 LEU A CG  1 
ATOM   4510 C CD1 . LEU A 1 585 ? 135.606 119.146 185.631 1.00 62.19  ? 611 LEU A CD1 1 
ATOM   4511 C CD2 . LEU A 1 585 ? 135.406 120.494 183.534 1.00 59.69  ? 611 LEU A CD2 1 
ATOM   4512 N N   . GLU A 1 586 ? 138.428 123.022 186.585 1.00 69.50  ? 612 GLU A N   1 
ATOM   4513 C CA  . GLU A 1 586 ? 139.869 123.162 186.413 1.00 64.91  ? 612 GLU A CA  1 
ATOM   4514 C C   . GLU A 1 586 ? 140.603 122.967 187.732 1.00 64.28  ? 612 GLU A C   1 
ATOM   4515 O O   . GLU A 1 586 ? 141.672 122.350 187.762 1.00 73.31  ? 612 GLU A O   1 
ATOM   4516 C CB  . GLU A 1 586 ? 140.196 124.524 185.805 1.00 66.15  ? 612 GLU A CB  1 
ATOM   4517 C CG  . GLU A 1 586 ? 141.658 124.709 185.449 1.00 68.72  ? 612 GLU A CG  1 
ATOM   4518 C CD  . GLU A 1 586 ? 141.895 125.932 184.588 1.00 72.93  ? 612 GLU A CD  1 
ATOM   4519 O OE1 . GLU A 1 586 ? 140.905 126.516 184.100 1.00 73.80  ? 612 GLU A OE1 1 
ATOM   4520 O OE2 . GLU A 1 586 ? 143.070 126.311 184.399 1.00 72.90  ? 612 GLU A OE2 1 
ATOM   4521 N N   . GLN A 1 587 ? 140.047 123.475 188.834 1.00 66.26  ? 613 GLN A N   1 
ATOM   4522 C CA  . GLN A 1 587 ? 140.678 123.246 190.132 1.00 71.63  ? 613 GLN A CA  1 
ATOM   4523 C C   . GLN A 1 587 ? 140.674 121.766 190.498 1.00 73.10  ? 613 GLN A C   1 
ATOM   4524 O O   . GLN A 1 587 ? 141.679 121.240 190.994 1.00 79.90  ? 613 GLN A O   1 
ATOM   4525 C CB  . GLN A 1 587 ? 139.983 124.071 191.214 1.00 74.95  ? 613 GLN A CB  1 
ATOM   4526 C CG  . GLN A 1 587 ? 140.236 125.566 191.109 1.00 76.95  ? 613 GLN A CG  1 
ATOM   4527 C CD  . GLN A 1 587 ? 139.691 126.333 192.296 1.00 79.14  ? 613 GLN A CD  1 
ATOM   4528 O OE1 . GLN A 1 587 ? 139.112 125.751 193.213 1.00 76.68  ? 613 GLN A OE1 1 
ATOM   4529 N NE2 . GLN A 1 587 ? 139.876 127.648 192.286 1.00 77.78  ? 613 GLN A NE2 1 
ATOM   4530 N N   . ASP A 1 588 ? 139.558 121.074 190.254 1.00 73.39  ? 614 ASP A N   1 
ATOM   4531 C CA  . ASP A 1 588 ? 139.501 119.644 190.545 1.00 75.10  ? 614 ASP A CA  1 
ATOM   4532 C C   . ASP A 1 588 ? 140.475 118.860 189.671 1.00 78.86  ? 614 ASP A C   1 
ATOM   4533 O O   . ASP A 1 588 ? 141.136 117.931 190.148 1.00 84.81  ? 614 ASP A O   1 
ATOM   4534 C CB  . ASP A 1 588 ? 138.076 119.127 190.362 1.00 81.36  ? 614 ASP A CB  1 
ATOM   4535 C CG  . ASP A 1 588 ? 137.103 119.742 191.347 1.00 85.60  ? 614 ASP A CG  1 
ATOM   4536 O OD1 . ASP A 1 588 ? 137.543 120.551 192.191 1.00 85.53  ? 614 ASP A OD1 1 
ATOM   4537 O OD2 . ASP A 1 588 ? 135.899 119.418 191.278 1.00 85.01  ? 614 ASP A OD2 1 
ATOM   4538 N N   . LEU A 1 589 ? 140.578 119.220 188.390 1.00 81.64  ? 615 LEU A N   1 
ATOM   4539 C CA  . LEU A 1 589 ? 141.513 118.537 187.502 1.00 79.96  ? 615 LEU A CA  1 
ATOM   4540 C C   . LEU A 1 589 ? 142.955 118.805 187.912 1.00 82.36  ? 615 LEU A C   1 
ATOM   4541 O O   . LEU A 1 589 ? 143.807 117.915 187.818 1.00 87.91  ? 615 LEU A O   1 
ATOM   4542 C CB  . LEU A 1 589 ? 141.267 118.966 186.055 1.00 82.43  ? 615 LEU A CB  1 
ATOM   4543 C CG  . LEU A 1 589 ? 141.987 118.197 184.945 1.00 88.39  ? 615 LEU A CG  1 
ATOM   4544 C CD1 . LEU A 1 589 ? 141.082 118.056 183.731 1.00 87.44  ? 615 LEU A CD1 1 
ATOM   4545 C CD2 . LEU A 1 589 ? 143.288 118.882 184.555 1.00 86.20  ? 615 LEU A CD2 1 
ATOM   4546 N N   . ALA A 1 590 ? 143.249 120.024 188.369 1.00 86.49  ? 616 ALA A N   1 
ATOM   4547 C CA  . ALA A 1 590 ? 144.586 120.323 188.866 1.00 87.74  ? 616 ALA A CA  1 
ATOM   4548 C C   . ALA A 1 590 ? 144.903 119.509 190.112 1.00 88.54  ? 616 ALA A C   1 
ATOM   4549 O O   . ALA A 1 590 ? 146.022 119.005 190.262 1.00 95.17  ? 616 ALA A O   1 
ATOM   4550 C CB  . ALA A 1 590 ? 144.719 121.819 189.151 1.00 88.69  ? 616 ALA A CB  1 
ATOM   4551 N N   . TYR A 1 591 ? 143.931 119.366 191.016 1.00 90.61  ? 617 TYR A N   1 
ATOM   4552 C CA  . TYR A 1 591 ? 144.144 118.532 192.195 1.00 93.39  ? 617 TYR A CA  1 
ATOM   4553 C C   . TYR A 1 591 ? 144.383 117.079 191.805 1.00 94.68  ? 617 TYR A C   1 
ATOM   4554 O O   . TYR A 1 591 ? 145.253 116.407 192.374 1.00 99.19  ? 617 TYR A O   1 
ATOM   4555 C CB  . TYR A 1 591 ? 142.950 118.642 193.141 1.00 95.51  ? 617 TYR A CB  1 
ATOM   4556 C CG  . TYR A 1 591 ? 142.990 117.662 194.292 1.00 97.22  ? 617 TYR A CG  1 
ATOM   4557 C CD1 . TYR A 1 591 ? 143.773 117.909 195.411 1.00 97.09  ? 617 TYR A CD1 1 
ATOM   4558 C CD2 . TYR A 1 591 ? 142.242 116.493 194.260 1.00 96.98  ? 617 TYR A CD2 1 
ATOM   4559 C CE1 . TYR A 1 591 ? 143.813 117.016 196.466 1.00 98.23  ? 617 TYR A CE1 1 
ATOM   4560 C CE2 . TYR A 1 591 ? 142.275 115.595 195.310 1.00 97.94  ? 617 TYR A CE2 1 
ATOM   4561 C CZ  . TYR A 1 591 ? 143.062 115.861 196.410 1.00 100.15 ? 617 TYR A CZ  1 
ATOM   4562 O OH  . TYR A 1 591 ? 143.098 114.970 197.458 1.00 100.98 ? 617 TYR A OH  1 
ATOM   4563 N N   . LEU A 1 592 ? 143.621 116.576 190.831 1.00 92.68  ? 618 LEU A N   1 
ATOM   4564 C CA  . LEU A 1 592 ? 143.806 115.200 190.385 1.00 94.74  ? 618 LEU A CA  1 
ATOM   4565 C C   . LEU A 1 592 ? 145.175 115.005 189.746 1.00 95.98  ? 618 LEU A C   1 
ATOM   4566 O O   . LEU A 1 592 ? 145.835 113.984 189.974 1.00 101.84 ? 618 LEU A O   1 
ATOM   4567 C CB  . LEU A 1 592 ? 142.696 114.809 189.411 1.00 98.78  ? 618 LEU A CB  1 
ATOM   4568 C CG  . LEU A 1 592 ? 142.578 113.314 189.111 1.00 101.03 ? 618 LEU A CG  1 
ATOM   4569 C CD1 . LEU A 1 592 ? 142.268 112.543 190.384 1.00 98.73  ? 618 LEU A CD1 1 
ATOM   4570 C CD2 . LEU A 1 592 ? 141.518 113.057 188.053 1.00 99.25  ? 618 LEU A CD2 1 
ATOM   4571 N N   . GLN A 1 593 ? 145.621 115.974 188.944 1.00 97.48  ? 619 GLN A N   1 
ATOM   4572 C CA  . GLN A 1 593 ? 146.940 115.873 188.328 1.00 98.43  ? 619 GLN A CA  1 
ATOM   4573 C C   . GLN A 1 593 ? 148.042 115.945 189.376 1.00 99.66  ? 619 GLN A C   1 
ATOM   4574 O O   . GLN A 1 593 ? 149.058 115.250 189.264 1.00 105.15 ? 619 GLN A O   1 
ATOM   4575 C CB  . GLN A 1 593 ? 147.118 116.971 187.281 1.00 102.69 ? 619 GLN A CB  1 
ATOM   4576 C CG  . GLN A 1 593 ? 148.433 116.897 186.523 1.00 104.12 ? 619 GLN A CG  1 
ATOM   4577 C CD  . GLN A 1 593 ? 148.542 117.954 185.442 1.00 107.20 ? 619 GLN A CD  1 
ATOM   4578 O OE1 . GLN A 1 593 ? 147.645 118.780 185.272 1.00 107.28 ? 619 GLN A OE1 1 
ATOM   4579 N NE2 . GLN A 1 593 ? 149.645 117.932 184.702 1.00 105.21 ? 619 GLN A NE2 1 
ATOM   4580 N N   . GLU A 1 594 ? 147.856 116.773 190.406 1.00 105.45 ? 620 GLU A N   1 
ATOM   4581 C CA  . GLU A 1 594 ? 148.830 116.828 191.491 1.00 107.41 ? 620 GLU A CA  1 
ATOM   4582 C C   . GLU A 1 594 ? 148.897 115.501 192.235 1.00 107.47 ? 620 GLU A C   1 
ATOM   4583 O O   . GLU A 1 594 ? 149.986 115.035 192.588 1.00 110.26 ? 620 GLU A O   1 
ATOM   4584 C CB  . GLU A 1 594 ? 148.483 117.966 192.450 1.00 109.32 ? 620 GLU A CB  1 
ATOM   4585 C CG  . GLU A 1 594 ? 149.446 118.112 193.617 1.00 111.22 ? 620 GLU A CG  1 
ATOM   4586 C CD  . GLU A 1 594 ? 149.072 119.253 194.542 1.00 111.65 ? 620 GLU A CD  1 
ATOM   4587 O OE1 . GLU A 1 594 ? 148.053 119.925 194.277 1.00 110.55 ? 620 GLU A OE1 1 
ATOM   4588 O OE2 . GLU A 1 594 ? 149.797 119.479 195.533 1.00 110.17 ? 620 GLU A OE2 1 
ATOM   4589 N N   . LEU A 1 595 ? 147.743 114.874 192.474 1.00 112.01 ? 621 LEU A N   1 
ATOM   4590 C CA  . LEU A 1 595 ? 147.737 113.566 193.122 1.00 114.62 ? 621 LEU A CA  1 
ATOM   4591 C C   . LEU A 1 595 ? 148.419 112.515 192.252 1.00 114.52 ? 621 LEU A C   1 
ATOM   4592 O O   . LEU A 1 595 ? 149.167 111.669 192.759 1.00 114.32 ? 621 LEU A O   1 
ATOM   4593 C CB  . LEU A 1 595 ? 146.303 113.150 193.448 1.00 117.40 ? 621 LEU A CB  1 
ATOM   4594 C CG  . LEU A 1 595 ? 146.123 111.846 194.229 1.00 117.76 ? 621 LEU A CG  1 
ATOM   4595 C CD1 . LEU A 1 595 ? 146.895 111.893 195.538 1.00 116.73 ? 621 LEU A CD1 1 
ATOM   4596 C CD2 . LEU A 1 595 ? 144.648 111.578 194.485 1.00 115.00 ? 621 LEU A CD2 1 
ATOM   4597 N N   . LYS A 1 596 ? 148.173 112.552 190.940 1.00 116.71 ? 622 LYS A N   1 
ATOM   4598 C CA  . LYS A 1 596 ? 148.832 111.612 190.039 1.00 115.64 ? 622 LYS A CA  1 
ATOM   4599 C C   . LYS A 1 596 ? 150.343 111.812 190.043 1.00 115.34 ? 622 LYS A C   1 
ATOM   4600 O O   . LYS A 1 596 ? 151.105 110.840 190.043 1.00 114.54 ? 622 LYS A O   1 
ATOM   4601 C CB  . LYS A 1 596 ? 148.277 111.759 188.623 1.00 116.83 ? 622 LYS A CB  1 
ATOM   4602 C CG  . LYS A 1 596 ? 148.781 110.702 187.651 1.00 116.30 ? 622 LYS A CG  1 
ATOM   4603 C CD  . LYS A 1 596 ? 148.303 110.963 186.229 1.00 117.07 ? 622 LYS A CD  1 
ATOM   4604 C CE  . LYS A 1 596 ? 149.316 111.774 185.430 1.00 117.22 ? 622 LYS A CE  1 
ATOM   4605 N NZ  . LYS A 1 596 ? 149.535 113.141 185.978 1.00 116.68 ? 622 LYS A NZ  1 
ATOM   4606 N N   . GLU A 1 597 ? 150.795 113.069 190.054 1.00 126.71 ? 623 GLU A N   1 
ATOM   4607 C CA  . GLU A 1 597 ? 152.230 113.336 190.103 1.00 126.81 ? 623 GLU A CA  1 
ATOM   4608 C C   . GLU A 1 597 ? 152.833 112.883 191.428 1.00 127.95 ? 623 GLU A C   1 
ATOM   4609 O O   . GLU A 1 597 ? 153.964 112.384 191.461 1.00 129.46 ? 623 GLU A O   1 
ATOM   4610 C CB  . GLU A 1 597 ? 152.497 114.823 189.871 1.00 126.52 ? 623 GLU A CB  1 
ATOM   4611 C CG  . GLU A 1 597 ? 152.175 115.298 188.463 1.00 128.17 ? 623 GLU A CG  1 
ATOM   4612 C CD  . GLU A 1 597 ? 152.451 116.775 188.269 1.00 128.77 ? 623 GLU A CD  1 
ATOM   4613 O OE1 . GLU A 1 597 ? 152.893 117.432 189.235 1.00 129.45 ? 623 GLU A OE1 1 
ATOM   4614 O OE2 . GLU A 1 597 ? 152.226 117.281 187.149 1.00 128.19 ? 623 GLU A OE2 1 
ATOM   4615 N N   . LYS A 1 598 ? 152.098 113.054 192.530 1.00 133.33 ? 624 LYS A N   1 
ATOM   4616 C CA  . LYS A 1 598 ? 152.575 112.564 193.818 1.00 134.01 ? 624 LYS A CA  1 
ATOM   4617 C C   . LYS A 1 598 ? 152.683 111.045 193.833 1.00 133.13 ? 624 LYS A C   1 
ATOM   4618 O O   . LYS A 1 598 ? 153.609 110.495 194.439 1.00 131.52 ? 624 LYS A O   1 
ATOM   4619 C CB  . LYS A 1 598 ? 151.656 113.041 194.943 1.00 133.13 ? 624 LYS A CB  1 
ATOM   4620 C CG  . LYS A 1 598 ? 151.764 114.526 195.248 1.00 132.83 ? 624 LYS A CG  1 
ATOM   4621 C CD  . LYS A 1 598 ? 150.897 114.906 196.437 1.00 132.09 ? 624 LYS A CD  1 
ATOM   4622 C CE  . LYS A 1 598 ? 151.048 116.378 196.783 1.00 131.96 ? 624 LYS A CE  1 
ATOM   4623 N NZ  . LYS A 1 598 ? 150.228 116.757 197.967 1.00 131.72 ? 624 LYS A NZ  1 
ATOM   4624 N N   . VAL A 1 599 ? 151.743 110.354 193.188 1.00 134.31 ? 625 VAL A N   1 
ATOM   4625 C CA  . VAL A 1 599 ? 151.858 108.905 193.053 1.00 134.48 ? 625 VAL A CA  1 
ATOM   4626 C C   . VAL A 1 599 ? 153.068 108.544 192.198 1.00 132.65 ? 625 VAL A C   1 
ATOM   4627 O O   . VAL A 1 599 ? 153.809 107.603 192.509 1.00 132.32 ? 625 VAL A O   1 
ATOM   4628 C CB  . VAL A 1 599 ? 150.557 108.316 192.476 1.00 134.97 ? 625 VAL A CB  1 
ATOM   4629 C CG1 . VAL A 1 599 ? 150.730 106.836 192.172 1.00 133.74 ? 625 VAL A CG1 1 
ATOM   4630 C CG2 . VAL A 1 599 ? 149.405 108.528 193.445 1.00 133.70 ? 625 VAL A CG2 1 
ATOM   4631 N N   . GLU A 1 600 ? 153.293 109.292 191.116 1.00 131.26 ? 626 GLU A N   1 
ATOM   4632 C CA  . GLU A 1 600 ? 154.371 108.961 190.188 1.00 132.05 ? 626 GLU A CA  1 
ATOM   4633 C C   . GLU A 1 600 ? 155.745 109.174 190.813 1.00 130.71 ? 626 GLU A C   1 
ATOM   4634 O O   . GLU A 1 600 ? 156.664 108.381 190.580 1.00 131.78 ? 626 GLU A O   1 
ATOM   4635 C CB  . GLU A 1 600 ? 154.233 109.787 188.909 1.00 132.80 ? 626 GLU A CB  1 
ATOM   4636 C CG  . GLU A 1 600 ? 153.081 109.360 188.013 1.00 133.24 ? 626 GLU A CG  1 
ATOM   4637 C CD  . GLU A 1 600 ? 152.968 110.212 186.764 1.00 133.09 ? 626 GLU A CD  1 
ATOM   4638 O OE1 . GLU A 1 600 ? 153.723 111.200 186.647 1.00 132.91 ? 626 GLU A OE1 1 
ATOM   4639 O OE2 . GLU A 1 600 ? 152.125 109.893 185.899 1.00 133.23 ? 626 GLU A OE2 1 
ATOM   4640 N N   . ASN A 1 601 ? 155.911 110.232 191.605 1.00 129.93 ? 627 ASN A N   1 
ATOM   4641 C CA  . ASN A 1 601 ? 157.232 110.556 192.132 1.00 131.53 ? 627 ASN A CA  1 
ATOM   4642 C C   . ASN A 1 601 ? 157.637 109.685 193.314 1.00 132.37 ? 627 ASN A C   1 
ATOM   4643 O O   . ASN A 1 601 ? 158.760 109.828 193.809 1.00 133.71 ? 627 ASN A O   1 
ATOM   4644 C CB  . ASN A 1 601 ? 157.308 112.039 192.521 1.00 131.79 ? 627 ASN A CB  1 
ATOM   4645 C CG  . ASN A 1 601 ? 156.285 112.434 193.574 1.00 132.49 ? 627 ASN A CG  1 
ATOM   4646 O OD1 . ASN A 1 601 ? 156.048 111.711 194.541 1.00 131.01 ? 627 ASN A OD1 1 
ATOM   4647 N ND2 . ASN A 1 601 ? 155.680 113.601 193.391 1.00 133.62 ? 627 ASN A ND2 1 
ATOM   4648 N N   . GLY A 1 602 ? 156.762 108.796 193.777 1.00 135.94 ? 628 GLY A N   1 
ATOM   4649 C CA  . GLY A 1 602 ? 157.073 107.891 194.866 1.00 137.08 ? 628 GLY A CA  1 
ATOM   4650 C C   . GLY A 1 602 ? 156.360 108.191 196.164 1.00 138.45 ? 628 GLY A C   1 
ATOM   4651 O O   . GLY A 1 602 ? 156.373 107.342 197.066 1.00 138.82 ? 628 GLY A O   1 
ATOM   4652 N N   . SER A 1 603 ? 155.738 109.359 196.296 1.00 150.39 ? 629 SER A N   1 
ATOM   4653 C CA  . SER A 1 603 ? 155.000 109.690 197.503 1.00 151.84 ? 629 SER A CA  1 
ATOM   4654 C C   . SER A 1 603 ? 153.633 109.007 197.485 1.00 152.69 ? 629 SER A C   1 
ATOM   4655 O O   . SER A 1 603 ? 153.300 108.245 196.572 1.00 152.93 ? 629 SER A O   1 
ATOM   4656 C CB  . SER A 1 603 ? 154.864 111.204 197.644 1.00 151.21 ? 629 SER A CB  1 
ATOM   4657 O OG  . SER A 1 603 ? 154.242 111.767 196.504 1.00 149.77 ? 629 SER A OG  1 
ATOM   4658 N N   . GLU A 1 604 ? 152.830 109.287 198.515 1.00 171.90 ? 630 GLU A N   1 
ATOM   4659 C CA  . GLU A 1 604 ? 151.500 108.698 198.678 1.00 172.80 ? 630 GLU A CA  1 
ATOM   4660 C C   . GLU A 1 604 ? 151.585 107.170 198.707 1.00 173.66 ? 630 GLU A C   1 
ATOM   4661 O O   . GLU A 1 604 ? 151.055 106.466 197.844 1.00 173.56 ? 630 GLU A O   1 
ATOM   4662 C CB  . GLU A 1 604 ? 150.542 109.188 197.585 1.00 171.94 ? 630 GLU A CB  1 
ATOM   4663 C CG  . GLU A 1 604 ? 149.069 108.934 197.879 1.00 172.34 ? 630 GLU A CG  1 
ATOM   4664 C CD  . GLU A 1 604 ? 148.549 109.765 199.037 1.00 172.61 ? 630 GLU A CD  1 
ATOM   4665 O OE1 . GLU A 1 604 ? 149.157 110.813 199.343 1.00 173.01 ? 630 GLU A OE1 1 
ATOM   4666 O OE2 . GLU A 1 604 ? 147.531 109.370 199.642 1.00 171.82 ? 630 GLU A OE2 1 
ATOM   4667 N N   . THR A 1 605 ? 152.286 106.666 199.726 1.00 186.09 ? 631 THR A N   1 
ATOM   4668 C CA  . THR A 1 605 ? 152.511 105.231 199.860 1.00 186.60 ? 631 THR A CA  1 
ATOM   4669 C C   . THR A 1 605 ? 151.223 104.450 200.093 1.00 186.63 ? 631 THR A C   1 
ATOM   4670 O O   . THR A 1 605 ? 151.210 103.231 199.891 1.00 186.02 ? 631 THR A O   1 
ATOM   4671 C CB  . THR A 1 605 ? 153.491 104.954 201.001 1.00 186.02 ? 631 THR A CB  1 
ATOM   4672 O OG1 . THR A 1 605 ? 152.947 105.448 202.231 1.00 185.75 ? 631 THR A OG1 1 
ATOM   4673 C CG2 . THR A 1 605 ? 154.826 105.634 200.734 1.00 184.84 ? 631 THR A CG2 1 
ATOM   4674 N N   . GLY A 1 606 ? 150.150 105.114 200.515 1.00 190.42 ? 632 GLY A N   1 
ATOM   4675 C CA  . GLY A 1 606 ? 148.891 104.451 200.756 1.00 189.66 ? 632 GLY A CA  1 
ATOM   4676 C C   . GLY A 1 606 ? 148.268 103.924 199.479 1.00 190.45 ? 632 GLY A C   1 
ATOM   4677 O O   . GLY A 1 606 ? 148.641 104.320 198.370 1.00 190.45 ? 632 GLY A O   1 
ATOM   4678 N N   . PRO A 1 607 ? 147.308 103.010 199.613 1.00 191.38 ? 633 PRO A N   1 
ATOM   4679 C CA  . PRO A 1 607 ? 146.681 102.423 198.422 1.00 190.79 ? 633 PRO A CA  1 
ATOM   4680 C C   . PRO A 1 607 ? 145.922 103.466 197.617 1.00 190.62 ? 633 PRO A C   1 
ATOM   4681 O O   . PRO A 1 607 ? 145.327 104.395 198.169 1.00 191.16 ? 633 PRO A O   1 
ATOM   4682 C CB  . PRO A 1 607 ? 145.735 101.365 199.003 1.00 189.98 ? 633 PRO A CB  1 
ATOM   4683 C CG  . PRO A 1 607 ? 145.455 101.835 200.394 1.00 189.98 ? 633 PRO A CG  1 
ATOM   4684 C CD  . PRO A 1 607 ? 146.723 102.491 200.862 1.00 190.27 ? 633 PRO A CD  1 
ATOM   4685 N N   . LEU A 1 608 ? 145.951 103.303 196.298 1.00 176.28 ? 634 LEU A N   1 
ATOM   4686 C CA  . LEU A 1 608 ? 145.293 104.251 195.417 1.00 175.72 ? 634 LEU A CA  1 
ATOM   4687 C C   . LEU A 1 608 ? 143.778 104.048 195.447 1.00 174.99 ? 634 LEU A C   1 
ATOM   4688 O O   . LEU A 1 608 ? 143.295 102.930 195.644 1.00 174.82 ? 634 LEU A O   1 
ATOM   4689 C CB  . LEU A 1 608 ? 145.808 104.107 193.986 1.00 175.11 ? 634 LEU A CB  1 
ATOM   4690 C CG  . LEU A 1 608 ? 145.259 102.989 193.091 1.00 175.11 ? 634 LEU A CG  1 
ATOM   4691 C CD1 . LEU A 1 608 ? 145.758 103.165 191.666 1.00 174.60 ? 634 LEU A CD1 1 
ATOM   4692 C CD2 . LEU A 1 608 ? 145.626 101.606 193.612 1.00 175.14 ? 634 LEU A CD2 1 
ATOM   4693 N N   . PRO A 1 609 ? 143.006 105.122 195.265 1.00 167.35 ? 635 PRO A N   1 
ATOM   4694 C CA  . PRO A 1 609 ? 141.560 104.964 195.151 1.00 167.09 ? 635 PRO A CA  1 
ATOM   4695 C C   . PRO A 1 609 ? 141.202 104.222 193.878 1.00 166.62 ? 635 PRO A C   1 
ATOM   4696 O O   . PRO A 1 609 ? 141.957 104.256 192.890 1.00 165.06 ? 635 PRO A O   1 
ATOM   4697 C CB  . PRO A 1 609 ? 141.046 106.416 195.118 1.00 167.27 ? 635 PRO A CB  1 
ATOM   4698 C CG  . PRO A 1 609 ? 142.150 107.229 195.707 1.00 166.78 ? 635 PRO A CG  1 
ATOM   4699 C CD  . PRO A 1 609 ? 143.409 106.537 195.295 1.00 166.95 ? 635 PRO A CD  1 
ATOM   4700 N N   . PRO A 1 610 ? 140.064 103.524 193.854 1.00 163.46 ? 636 PRO A N   1 
ATOM   4701 C CA  . PRO A 1 610 ? 139.672 102.816 192.624 1.00 163.50 ? 636 PRO A CA  1 
ATOM   4702 C C   . PRO A 1 610 ? 139.475 103.740 191.436 1.00 162.73 ? 636 PRO A C   1 
ATOM   4703 O O   . PRO A 1 610 ? 139.654 103.307 190.291 1.00 162.34 ? 636 PRO A O   1 
ATOM   4704 C CB  . PRO A 1 610 ? 138.365 102.118 193.025 1.00 162.70 ? 636 PRO A CB  1 
ATOM   4705 C CG  . PRO A 1 610 ? 137.842 102.922 194.172 1.00 162.14 ? 636 PRO A CG  1 
ATOM   4706 C CD  . PRO A 1 610 ? 139.055 103.390 194.918 1.00 162.72 ? 636 PRO A CD  1 
ATOM   4707 N N   . GLU A 1 611 ? 139.111 105.002 191.673 1.00 154.04 ? 637 GLU A N   1 
ATOM   4708 C CA  . GLU A 1 611 ? 138.982 105.957 190.580 1.00 152.86 ? 637 GLU A CA  1 
ATOM   4709 C C   . GLU A 1 611 ? 140.332 106.350 189.997 1.00 153.04 ? 637 GLU A C   1 
ATOM   4710 O O   . GLU A 1 611 ? 140.393 106.770 188.836 1.00 153.10 ? 637 GLU A O   1 
ATOM   4711 C CB  . GLU A 1 611 ? 138.236 107.205 191.053 1.00 151.94 ? 637 GLU A CB  1 
ATOM   4712 C CG  . GLU A 1 611 ? 136.830 106.930 191.563 1.00 152.84 ? 637 GLU A CG  1 
ATOM   4713 C CD  . GLU A 1 611 ? 135.908 106.389 190.485 1.00 153.54 ? 637 GLU A CD  1 
ATOM   4714 O OE1 . GLU A 1 611 ? 136.146 106.677 189.293 1.00 153.20 ? 637 GLU A OE1 1 
ATOM   4715 O OE2 . GLU A 1 611 ? 134.945 105.673 190.831 1.00 153.70 ? 637 GLU A OE2 1 
ATOM   4716 N N   . LEU A 1 612 ? 141.409 106.235 190.774 1.00 160.64 ? 638 LEU A N   1 
ATOM   4717 C CA  . LEU A 1 612 ? 142.738 106.552 190.268 1.00 163.15 ? 638 LEU A CA  1 
ATOM   4718 C C   . LEU A 1 612 ? 143.317 105.433 189.413 1.00 162.34 ? 638 LEU A C   1 
ATOM   4719 O O   . LEU A 1 612 ? 144.265 105.674 188.658 1.00 161.99 ? 638 LEU A O   1 
ATOM   4720 C CB  . LEU A 1 612 ? 143.679 106.864 191.436 1.00 163.52 ? 638 LEU A CB  1 
ATOM   4721 C CG  . LEU A 1 612 ? 144.950 107.670 191.153 1.00 163.47 ? 638 LEU A CG  1 
ATOM   4722 C CD1 . LEU A 1 612 ? 145.213 108.647 192.286 1.00 161.73 ? 638 LEU A CD1 1 
ATOM   4723 C CD2 . LEU A 1 612 ? 146.151 106.758 190.957 1.00 161.87 ? 638 LEU A CD2 1 
ATOM   4724 N N   . GLN A 1 613 ? 142.765 104.223 189.507 1.00 161.66 ? 639 GLN A N   1 
ATOM   4725 C CA  . GLN A 1 613 ? 143.276 103.115 188.705 1.00 162.24 ? 639 GLN A CA  1 
ATOM   4726 C C   . GLN A 1 613 ? 143.175 103.358 187.202 1.00 162.53 ? 639 GLN A C   1 
ATOM   4727 O O   . GLN A 1 613 ? 144.161 103.074 186.497 1.00 162.65 ? 639 GLN A O   1 
ATOM   4728 C CB  . GLN A 1 613 ? 142.560 101.816 189.101 1.00 162.87 ? 639 GLN A CB  1 
ATOM   4729 C CG  . GLN A 1 613 ? 142.669 101.469 190.576 1.00 162.77 ? 639 GLN A CG  1 
ATOM   4730 C CD  . GLN A 1 613 ? 141.963 100.173 190.922 1.00 163.12 ? 639 GLN A CD  1 
ATOM   4731 O OE1 . GLN A 1 613 ? 141.411 99.502  190.051 1.00 162.71 ? 639 GLN A OE1 1 
ATOM   4732 N NE2 . GLN A 1 613 ? 141.978 99.815  192.201 1.00 163.14 ? 639 GLN A NE2 1 
ATOM   4733 N N   . PRO A 1 614 ? 142.058 103.849 186.644 1.00 161.01 ? 640 PRO A N   1 
ATOM   4734 C CA  . PRO A 1 614 ? 142.045 104.146 185.202 1.00 161.59 ? 640 PRO A CA  1 
ATOM   4735 C C   . PRO A 1 614 ? 143.037 105.219 184.793 1.00 161.51 ? 640 PRO A C   1 
ATOM   4736 O O   . PRO A 1 614 ? 143.432 105.254 183.621 1.00 161.72 ? 640 PRO A O   1 
ATOM   4737 C CB  . PRO A 1 614 ? 140.601 104.599 184.946 1.00 160.29 ? 640 PRO A CB  1 
ATOM   4738 C CG  . PRO A 1 614 ? 139.815 103.986 186.044 1.00 159.74 ? 640 PRO A CG  1 
ATOM   4739 C CD  . PRO A 1 614 ? 140.718 104.018 187.236 1.00 160.38 ? 640 PRO A CD  1 
ATOM   4740 N N   . LEU A 1 615 ? 143.447 106.098 185.711 1.00 152.63 ? 641 LEU A N   1 
ATOM   4741 C CA  . LEU A 1 615 ? 144.464 107.088 185.377 1.00 152.01 ? 641 LEU A CA  1 
ATOM   4742 C C   . LEU A 1 615 ? 145.795 106.420 185.059 1.00 152.59 ? 641 LEU A C   1 
ATOM   4743 O O   . LEU A 1 615 ? 146.471 106.794 184.093 1.00 152.15 ? 641 LEU A O   1 
ATOM   4744 C CB  . LEU A 1 615 ? 144.626 108.084 186.524 1.00 151.70 ? 641 LEU A CB  1 
ATOM   4745 C CG  . LEU A 1 615 ? 143.355 108.784 187.007 1.00 152.69 ? 641 LEU A CG  1 
ATOM   4746 C CD1 . LEU A 1 615 ? 143.668 109.738 188.149 1.00 152.45 ? 641 LEU A CD1 1 
ATOM   4747 C CD2 . LEU A 1 615 ? 142.678 109.518 185.862 1.00 151.41 ? 641 LEU A CD2 1 
ATOM   4748 N N   . LEU A 1 616 ? 146.188 105.429 185.862 1.00 160.61 ? 642 LEU A N   1 
ATOM   4749 C CA  . LEU A 1 616 ? 147.426 104.706 185.598 1.00 160.76 ? 642 LEU A CA  1 
ATOM   4750 C C   . LEU A 1 616 ? 147.274 103.736 184.433 1.00 160.81 ? 642 LEU A C   1 
ATOM   4751 O O   . LEU A 1 616 ? 148.177 103.623 183.596 1.00 161.25 ? 642 LEU A O   1 
ATOM   4752 C CB  . LEU A 1 616 ? 147.875 103.960 186.855 1.00 160.36 ? 642 LEU A CB  1 
ATOM   4753 C CG  . LEU A 1 616 ? 148.156 104.820 188.089 1.00 160.83 ? 642 LEU A CG  1 
ATOM   4754 C CD1 . LEU A 1 616 ? 148.594 103.954 189.260 1.00 160.36 ? 642 LEU A CD1 1 
ATOM   4755 C CD2 . LEU A 1 616 ? 149.203 105.878 187.778 1.00 160.15 ? 642 LEU A CD2 1 
ATOM   4756 N N   . GLU A 1 617 ? 146.143 103.029 184.361 1.00 169.37 ? 643 GLU A N   1 
ATOM   4757 C CA  . GLU A 1 617 ? 145.959 102.048 183.296 1.00 170.35 ? 643 GLU A CA  1 
ATOM   4758 C C   . GLU A 1 617 ? 145.757 102.723 181.945 1.00 171.17 ? 643 GLU A C   1 
ATOM   4759 O O   . GLU A 1 617 ? 146.362 102.319 180.946 1.00 171.55 ? 643 GLU A O   1 
ATOM   4760 C CB  . GLU A 1 617 ? 144.779 101.133 183.621 1.00 170.53 ? 643 GLU A CB  1 
ATOM   4761 C CG  . GLU A 1 617 ? 144.978 100.279 184.863 1.00 170.75 ? 643 GLU A CG  1 
ATOM   4762 C CD  . GLU A 1 617 ? 143.825 99.324  185.103 1.00 171.17 ? 643 GLU A CD  1 
ATOM   4763 O OE1 . GLU A 1 617 ? 142.861 99.341  184.308 1.00 171.02 ? 643 GLU A OE1 1 
ATOM   4764 O OE2 . GLU A 1 617 ? 143.882 98.555  186.085 1.00 170.97 ? 643 GLU A OE2 1 
ATOM   4765 N N   . GLY A 1 618 ? 144.911 103.749 181.893 1.00 173.03 ? 644 GLY A N   1 
ATOM   4766 C CA  . GLY A 1 618 ? 144.636 104.457 180.662 1.00 172.57 ? 644 GLY A CA  1 
ATOM   4767 C C   . GLY A 1 618 ? 143.602 103.814 179.765 1.00 173.02 ? 644 GLY A C   1 
ATOM   4768 O O   . GLY A 1 618 ? 143.265 104.394 178.725 1.00 172.54 ? 644 GLY A O   1 
ATOM   4769 N N   . GLU A 1 619 ? 143.086 102.641 180.127 1.00 182.31 ? 645 GLU A N   1 
ATOM   4770 C CA  . GLU A 1 619 ? 142.058 101.963 179.347 1.00 182.56 ? 645 GLU A CA  1 
ATOM   4771 C C   . GLU A 1 619 ? 141.007 101.407 180.293 1.00 182.52 ? 645 GLU A C   1 
ATOM   4772 O O   . GLU A 1 619 ? 141.347 100.771 181.295 1.00 181.68 ? 645 GLU A O   1 
ATOM   4773 C CB  . GLU A 1 619 ? 142.655 100.836 178.495 1.00 182.41 ? 645 GLU A CB  1 
ATOM   4774 C CG  . GLU A 1 619 ? 143.618 101.306 177.417 1.00 182.17 ? 645 GLU A CG  1 
ATOM   4775 C CD  . GLU A 1 619 ? 144.190 100.161 176.605 1.00 181.84 ? 645 GLU A CD  1 
ATOM   4776 O OE1 . GLU A 1 619 ? 143.908 98.992  176.944 1.00 182.39 ? 645 GLU A OE1 1 
ATOM   4777 O OE2 . GLU A 1 619 ? 144.921 100.428 175.629 1.00 181.41 ? 645 GLU A OE2 1 
ATOM   4778 N N   . VAL A 1 620 ? 139.737 101.645 179.973 1.00 183.01 ? 646 VAL A N   1 
ATOM   4779 C CA  . VAL A 1 620 ? 138.623 101.158 180.790 1.00 182.85 ? 646 VAL A CA  1 
ATOM   4780 C C   . VAL A 1 620 ? 138.227 99.799  180.218 1.00 182.95 ? 646 VAL A C   1 
ATOM   4781 O O   . VAL A 1 620 ? 137.363 99.691  179.347 1.00 182.56 ? 646 VAL A O   1 
ATOM   4782 C CB  . VAL A 1 620 ? 137.458 102.143 180.817 1.00 182.39 ? 646 VAL A CB  1 
ATOM   4783 C CG1 . VAL A 1 620 ? 136.370 101.651 181.761 1.00 182.28 ? 646 VAL A CG1 1 
ATOM   4784 C CG2 . VAL A 1 620 ? 137.944 103.525 181.227 1.00 181.51 ? 646 VAL A CG2 1 
ATOM   4785 N N   . LYS A 1 621 ? 138.872 98.747  180.716 1.00 188.65 ? 647 LYS A N   1 
ATOM   4786 C CA  . LYS A 1 621 ? 138.577 97.380  180.311 1.00 188.41 ? 647 LYS A CA  1 
ATOM   4787 C C   . LYS A 1 621 ? 138.411 96.518  181.552 1.00 188.71 ? 647 LYS A C   1 
ATOM   4788 O O   . LYS A 1 621 ? 139.260 96.546  182.449 1.00 188.26 ? 647 LYS A O   1 
ATOM   4789 C CB  . LYS A 1 621 ? 139.682 96.814  179.412 1.00 187.49 ? 647 LYS A CB  1 
ATOM   4790 C CG  . LYS A 1 621 ? 139.837 97.541  178.086 1.00 187.35 ? 647 LYS A CG  1 
ATOM   4791 C CD  . LYS A 1 621 ? 140.923 96.908  177.231 1.00 187.18 ? 647 LYS A CD  1 
ATOM   4792 C CE  . LYS A 1 621 ? 141.055 97.619  175.894 1.00 186.96 ? 647 LYS A CE  1 
ATOM   4793 N NZ  . LYS A 1 621 ? 142.113 97.009  175.042 1.00 186.84 ? 647 LYS A NZ  1 
ATOM   4794 N N   . GLY A 1 622 ? 137.325 95.753  181.598 1.00 189.58 ? 648 GLY A N   1 
ATOM   4795 C CA  . GLY A 1 622 ? 137.073 94.881  182.735 1.00 189.31 ? 648 GLY A CA  1 
ATOM   4796 C C   . GLY A 1 622 ? 136.850 95.619  184.037 1.00 188.85 ? 648 GLY A C   1 
ATOM   4797 O O   . GLY A 1 622 ? 137.375 95.208  185.079 1.00 188.92 ? 648 GLY A O   1 
ATOM   4798 N N   . GLY A 1 623 ? 136.079 96.703  184.003 1.00 185.15 ? 649 GLY A N   1 
ATOM   4799 C CA  . GLY A 1 623 ? 135.818 97.486  185.186 1.00 185.11 ? 649 GLY A CA  1 
ATOM   4800 C C   . GLY A 1 623 ? 134.627 98.408  185.024 1.00 185.71 ? 649 GLY A C   1 
ATOM   4801 O O   . GLY A 1 623 ? 134.011 98.486  183.957 1.00 185.18 ? 649 GLY A O   1 
ATOM   4802 N N   . PRO A 1 624 ? 134.278 99.124  186.090 1.00 180.36 ? 650 PRO A N   1 
ATOM   4803 C CA  . PRO A 1 624 ? 133.142 100.047 186.021 1.00 179.71 ? 650 PRO A CA  1 
ATOM   4804 C C   . PRO A 1 624 ? 133.456 101.259 185.158 1.00 179.44 ? 650 PRO A C   1 
ATOM   4805 O O   . PRO A 1 624 ? 134.613 101.606 184.912 1.00 179.13 ? 650 PRO A O   1 
ATOM   4806 C CB  . PRO A 1 624 ? 132.922 100.448 187.483 1.00 178.14 ? 650 PRO A CB  1 
ATOM   4807 C CG  . PRO A 1 624 ? 134.266 100.290 188.111 1.00 177.83 ? 650 PRO A CG  1 
ATOM   4808 C CD  . PRO A 1 624 ? 134.907 99.115  187.422 1.00 178.43 ? 650 PRO A CD  1 
ATOM   4809 N N   . GLU A 1 625 ? 132.392 101.901 184.690 1.00 164.71 ? 651 GLU A N   1 
ATOM   4810 C CA  . GLU A 1 625 ? 132.543 103.086 183.855 1.00 163.50 ? 651 GLU A CA  1 
ATOM   4811 C C   . GLU A 1 625 ? 133.151 104.222 184.670 1.00 162.91 ? 651 GLU A C   1 
ATOM   4812 O O   . GLU A 1 625 ? 132.728 104.458 185.808 1.00 162.94 ? 651 GLU A O   1 
ATOM   4813 C CB  . GLU A 1 625 ? 131.194 103.510 183.279 1.00 163.31 ? 651 GLU A CB  1 
ATOM   4814 C CG  . GLU A 1 625 ? 130.533 102.456 182.406 1.00 162.72 ? 651 GLU A CG  1 
ATOM   4815 C CD  . GLU A 1 625 ? 129.202 102.915 181.846 1.00 162.30 ? 651 GLU A CD  1 
ATOM   4816 O OE1 . GLU A 1 625 ? 128.793 104.057 182.141 1.00 161.70 ? 651 GLU A OE1 1 
ATOM   4817 O OE2 . GLU A 1 625 ? 128.563 102.133 181.110 1.00 162.47 ? 651 GLU A OE2 1 
ATOM   4818 N N   . PRO A 1 626 ? 134.135 104.940 184.136 1.00 147.43 ? 652 PRO A N   1 
ATOM   4819 C CA  . PRO A 1 626 ? 134.777 106.005 184.911 1.00 146.76 ? 652 PRO A CA  1 
ATOM   4820 C C   . PRO A 1 626 ? 133.875 107.221 185.060 1.00 145.49 ? 652 PRO A C   1 
ATOM   4821 O O   . PRO A 1 626 ? 132.919 107.425 184.309 1.00 144.05 ? 652 PRO A O   1 
ATOM   4822 C CB  . PRO A 1 626 ? 136.022 106.339 184.085 1.00 145.69 ? 652 PRO A CB  1 
ATOM   4823 C CG  . PRO A 1 626 ? 135.631 105.998 182.687 1.00 145.59 ? 652 PRO A CG  1 
ATOM   4824 C CD  . PRO A 1 626 ? 134.723 104.799 182.792 1.00 146.15 ? 652 PRO A CD  1 
ATOM   4825 N N   . THR A 1 627 ? 134.203 108.037 186.059 1.00 125.30 ? 653 THR A N   1 
ATOM   4826 C CA  . THR A 1 627 ? 133.482 109.273 186.291 1.00 122.93 ? 653 THR A CA  1 
ATOM   4827 C C   . THR A 1 627 ? 133.766 110.264 185.165 1.00 123.78 ? 653 THR A C   1 
ATOM   4828 O O   . THR A 1 627 ? 134.786 110.161 184.479 1.00 125.60 ? 653 THR A O   1 
ATOM   4829 C CB  . THR A 1 627 ? 133.883 109.878 187.634 1.00 121.38 ? 653 THR A CB  1 
ATOM   4830 O OG1 . THR A 1 627 ? 135.256 110.283 187.587 1.00 121.91 ? 653 THR A OG1 1 
ATOM   4831 C CG2 . THR A 1 627 ? 133.701 108.862 188.749 1.00 121.80 ? 653 THR A CG2 1 
ATOM   4832 N N   . PRO A 1 628 ? 132.869 111.229 184.944 1.00 115.07 ? 654 PRO A N   1 
ATOM   4833 C CA  . PRO A 1 628 ? 133.127 112.236 183.903 1.00 114.26 ? 654 PRO A CA  1 
ATOM   4834 C C   . PRO A 1 628 ? 134.390 113.044 184.140 1.00 113.65 ? 654 PRO A C   1 
ATOM   4835 O O   . PRO A 1 628 ? 134.993 113.515 183.169 1.00 113.77 ? 654 PRO A O   1 
ATOM   4836 C CB  . PRO A 1 628 ? 131.876 113.123 183.955 1.00 114.39 ? 654 PRO A CB  1 
ATOM   4837 C CG  . PRO A 1 628 ? 130.816 112.240 184.517 1.00 114.03 ? 654 PRO A CG  1 
ATOM   4838 C CD  . PRO A 1 628 ? 131.513 111.354 185.507 1.00 114.48 ? 654 PRO A CD  1 
ATOM   4839 N N   . LEU A 1 629 ? 134.812 113.217 185.395 1.00 106.42 ? 655 LEU A N   1 
ATOM   4840 C CA  . LEU A 1 629 ? 136.065 113.914 185.663 1.00 106.23 ? 655 LEU A CA  1 
ATOM   4841 C C   . LEU A 1 629 ? 137.254 113.137 185.108 1.00 110.41 ? 655 LEU A C   1 
ATOM   4842 O O   . LEU A 1 629 ? 138.161 113.723 184.503 1.00 112.02 ? 655 LEU A O   1 
ATOM   4843 C CB  . LEU A 1 629 ? 136.218 114.142 187.168 1.00 105.22 ? 655 LEU A CB  1 
ATOM   4844 C CG  . LEU A 1 629 ? 137.020 115.348 187.666 1.00 107.68 ? 655 LEU A CG  1 
ATOM   4845 C CD1 . LEU A 1 629 ? 136.726 115.603 189.136 1.00 107.37 ? 655 LEU A CD1 1 
ATOM   4846 C CD2 . LEU A 1 629 ? 138.514 115.161 187.455 1.00 108.87 ? 655 LEU A CD2 1 
ATOM   4847 N N   . VAL A 1 630 ? 137.261 111.816 185.299 1.00 111.73 ? 656 VAL A N   1 
ATOM   4848 C CA  . VAL A 1 630 ? 138.346 110.993 184.776 1.00 109.30 ? 656 VAL A CA  1 
ATOM   4849 C C   . VAL A 1 630 ? 138.355 111.025 183.254 1.00 108.45 ? 656 VAL A C   1 
ATOM   4850 O O   . VAL A 1 630 ? 139.417 111.119 182.627 1.00 109.38 ? 656 VAL A O   1 
ATOM   4851 C CB  . VAL A 1 630 ? 138.228 109.555 185.312 1.00 110.31 ? 656 VAL A CB  1 
ATOM   4852 C CG1 . VAL A 1 630 ? 139.293 108.664 184.695 1.00 112.04 ? 656 VAL A CG1 1 
ATOM   4853 C CG2 . VAL A 1 630 ? 138.334 109.547 186.828 1.00 110.84 ? 656 VAL A CG2 1 
ATOM   4854 N N   . GLN A 1 631 ? 137.173 110.951 182.636 1.00 113.04 ? 657 GLN A N   1 
ATOM   4855 C CA  . GLN A 1 631 ? 137.094 111.021 181.181 1.00 115.16 ? 657 GLN A CA  1 
ATOM   4856 C C   . GLN A 1 631 ? 137.594 112.364 180.668 1.00 115.58 ? 657 GLN A C   1 
ATOM   4857 O O   . GLN A 1 631 ? 138.302 112.422 179.656 1.00 116.38 ? 657 GLN A O   1 
ATOM   4858 C CB  . GLN A 1 631 ? 135.659 110.769 180.719 1.00 115.07 ? 657 GLN A CB  1 
ATOM   4859 C CG  . GLN A 1 631 ? 135.106 109.413 181.120 1.00 116.80 ? 657 GLN A CG  1 
ATOM   4860 C CD  . GLN A 1 631 ? 133.687 109.196 180.630 1.00 117.41 ? 657 GLN A CD  1 
ATOM   4861 O OE1 . GLN A 1 631 ? 133.108 110.060 179.972 1.00 116.62 ? 657 GLN A OE1 1 
ATOM   4862 N NE2 . GLN A 1 631 ? 133.121 108.039 180.949 1.00 117.36 ? 657 GLN A NE2 1 
ATOM   4863 N N   . THR A 1 632 ? 137.242 113.453 181.355 1.00 110.47 ? 658 THR A N   1 
ATOM   4864 C CA  . THR A 1 632 ? 137.713 114.772 180.948 1.00 109.97 ? 658 THR A CA  1 
ATOM   4865 C C   . THR A 1 632 ? 139.227 114.878 181.070 1.00 111.25 ? 658 THR A C   1 
ATOM   4866 O O   . THR A 1 632 ? 139.889 115.429 180.182 1.00 113.86 ? 658 THR A O   1 
ATOM   4867 C CB  . THR A 1 632 ? 137.031 115.854 181.783 1.00 109.18 ? 658 THR A CB  1 
ATOM   4868 O OG1 . THR A 1 632 ? 135.609 115.715 181.679 1.00 109.03 ? 658 THR A OG1 1 
ATOM   4869 C CG2 . THR A 1 632 ? 137.434 117.237 181.295 1.00 109.42 ? 658 THR A CG2 1 
ATOM   4870 N N   . PHE A 1 633 ? 139.792 114.356 182.160 1.00 103.80 ? 659 PHE A N   1 
ATOM   4871 C CA  . PHE A 1 633 ? 141.241 114.403 182.329 1.00 104.26 ? 659 PHE A CA  1 
ATOM   4872 C C   . PHE A 1 633 ? 141.951 113.586 181.257 1.00 104.02 ? 659 PHE A C   1 
ATOM   4873 O O   . PHE A 1 633 ? 142.963 114.027 180.696 1.00 104.67 ? 659 PHE A O   1 
ATOM   4874 C CB  . PHE A 1 633 ? 141.624 113.908 183.722 1.00 101.61 ? 659 PHE A CB  1 
ATOM   4875 C CG  . PHE A 1 633 ? 143.099 113.734 183.915 1.00 99.31  ? 659 PHE A CG  1 
ATOM   4876 C CD1 . PHE A 1 633 ? 143.945 114.828 183.912 1.00 100.15 ? 659 PHE A CD1 1 
ATOM   4877 C CD2 . PHE A 1 633 ? 143.640 112.476 184.108 1.00 101.33 ? 659 PHE A CD2 1 
ATOM   4878 C CE1 . PHE A 1 633 ? 145.303 114.672 184.092 1.00 101.30 ? 659 PHE A CE1 1 
ATOM   4879 C CE2 . PHE A 1 633 ? 144.997 112.313 184.289 1.00 103.72 ? 659 PHE A CE2 1 
ATOM   4880 C CZ  . PHE A 1 633 ? 145.830 113.412 184.281 1.00 103.45 ? 659 PHE A CZ  1 
ATOM   4881 N N   . LEU A 1 634 ? 141.434 112.393 180.954 1.00 105.19 ? 660 LEU A N   1 
ATOM   4882 C CA  . LEU A 1 634 ? 142.042 111.573 179.911 1.00 104.65 ? 660 LEU A CA  1 
ATOM   4883 C C   . LEU A 1 634 ? 141.934 112.246 178.548 1.00 106.56 ? 660 LEU A C   1 
ATOM   4884 O O   . LEU A 1 634 ? 142.881 112.206 177.753 1.00 109.72 ? 660 LEU A O   1 
ATOM   4885 C CB  . LEU A 1 634 ? 141.395 110.190 179.883 1.00 106.38 ? 660 LEU A CB  1 
ATOM   4886 C CG  . LEU A 1 634 ? 141.638 109.301 181.104 1.00 108.04 ? 660 LEU A CG  1 
ATOM   4887 C CD1 . LEU A 1 634 ? 140.930 107.963 180.948 1.00 108.15 ? 660 LEU A CD1 1 
ATOM   4888 C CD2 . LEU A 1 634 ? 143.128 109.099 181.336 1.00 108.38 ? 660 LEU A CD2 1 
ATOM   4889 N N   . ARG A 1 635 ? 140.792 112.877 178.265 1.00 104.76 ? 661 ARG A N   1 
ATOM   4890 C CA  . ARG A 1 635 ? 140.630 113.576 176.995 1.00 105.48 ? 661 ARG A CA  1 
ATOM   4891 C C   . ARG A 1 635 ? 141.597 114.746 176.884 1.00 106.92 ? 661 ARG A C   1 
ATOM   4892 O O   . ARG A 1 635 ? 142.189 114.969 175.823 1.00 111.43 ? 661 ARG A O   1 
ATOM   4893 C CB  . ARG A 1 635 ? 139.187 114.056 176.844 1.00 106.50 ? 661 ARG A CB  1 
ATOM   4894 C CG  . ARG A 1 635 ? 138.912 114.806 175.551 1.00 108.12 ? 661 ARG A CG  1 
ATOM   4895 C CD  . ARG A 1 635 ? 137.520 115.425 175.538 1.00 109.51 ? 661 ARG A CD  1 
ATOM   4896 N NE  . ARG A 1 635 ? 136.460 114.428 175.635 1.00 111.59 ? 661 ARG A NE  1 
ATOM   4897 C CZ  . ARG A 1 635 ? 135.789 114.150 176.745 1.00 110.12 ? 661 ARG A CZ  1 
ATOM   4898 N NH1 . ARG A 1 635 ? 136.040 114.780 177.881 1.00 109.67 ? 661 ARG A NH1 1 
ATOM   4899 N NH2 . ARG A 1 635 ? 134.841 113.217 176.714 1.00 108.25 ? 661 ARG A NH2 1 
ATOM   4900 N N   . ARG A 1 636 ? 141.773 115.501 177.971 1.00 105.00 ? 662 ARG A N   1 
ATOM   4901 C CA  . ARG A 1 636 ? 142.708 116.619 177.946 1.00 107.63 ? 662 ARG A CA  1 
ATOM   4902 C C   . ARG A 1 636 ? 144.140 116.135 177.755 1.00 107.75 ? 662 ARG A C   1 
ATOM   4903 O O   . ARG A 1 636 ? 144.911 116.742 177.002 1.00 110.65 ? 662 ARG A O   1 
ATOM   4904 C CB  . ARG A 1 636 ? 142.581 117.440 179.228 1.00 109.10 ? 662 ARG A CB  1 
ATOM   4905 C CG  . ARG A 1 636 ? 143.416 118.709 179.233 1.00 110.44 ? 662 ARG A CG  1 
ATOM   4906 C CD  . ARG A 1 636 ? 143.142 119.545 180.471 1.00 110.83 ? 662 ARG A CD  1 
ATOM   4907 N NE  . ARG A 1 636 ? 143.886 120.799 180.457 1.00 111.14 ? 662 ARG A NE  1 
ATOM   4908 C CZ  . ARG A 1 636 ? 143.795 121.735 181.391 1.00 111.81 ? 662 ARG A CZ  1 
ATOM   4909 N NH1 . ARG A 1 636 ? 142.995 121.594 182.435 1.00 109.60 ? 662 ARG A NH1 1 
ATOM   4910 N NH2 . ARG A 1 636 ? 144.523 122.842 181.274 1.00 111.66 ? 662 ARG A NH2 1 
ATOM   4911 N N   . GLN A 1 637 ? 144.511 115.041 178.425 1.00 104.05 ? 663 GLN A N   1 
ATOM   4912 C CA  . GLN A 1 637 ? 145.852 114.492 178.249 1.00 104.43 ? 663 GLN A CA  1 
ATOM   4913 C C   . GLN A 1 637 ? 146.075 114.032 176.814 1.00 106.48 ? 663 GLN A C   1 
ATOM   4914 O O   . GLN A 1 637 ? 147.134 114.291 176.227 1.00 109.39 ? 663 GLN A O   1 
ATOM   4915 C CB  . GLN A 1 637 ? 146.078 113.337 179.223 1.00 105.07 ? 663 GLN A CB  1 
ATOM   4916 C CG  . GLN A 1 637 ? 147.453 112.702 179.123 1.00 107.08 ? 663 GLN A CG  1 
ATOM   4917 C CD  . GLN A 1 637 ? 147.625 111.531 180.069 1.00 108.79 ? 663 GLN A CD  1 
ATOM   4918 O OE1 . GLN A 1 637 ? 146.681 111.123 180.747 1.00 108.29 ? 663 GLN A OE1 1 
ATOM   4919 N NE2 . GLN A 1 637 ? 148.834 110.984 180.122 1.00 108.81 ? 663 GLN A NE2 1 
ATOM   4920 N N   . GLN A 1 638 ? 145.084 113.355 176.228 1.00 108.44 ? 664 GLN A N   1 
ATOM   4921 C CA  . GLN A 1 638 ? 145.217 112.898 174.849 1.00 109.11 ? 664 GLN A CA  1 
ATOM   4922 C C   . GLN A 1 638 ? 145.311 114.073 173.885 1.00 108.83 ? 664 GLN A C   1 
ATOM   4923 O O   . GLN A 1 638 ? 146.095 114.039 172.930 1.00 111.13 ? 664 GLN A O   1 
ATOM   4924 C CB  . GLN A 1 638 ? 144.043 111.991 174.481 1.00 110.02 ? 664 GLN A CB  1 
ATOM   4925 C CG  . GLN A 1 638 ? 144.105 111.433 173.068 1.00 111.06 ? 664 GLN A CG  1 
ATOM   4926 C CD  . GLN A 1 638 ? 142.927 110.536 172.743 1.00 110.88 ? 664 GLN A CD  1 
ATOM   4927 O OE1 . GLN A 1 638 ? 142.051 110.314 173.579 1.00 110.48 ? 664 GLN A OE1 1 
ATOM   4928 N NE2 . GLN A 1 638 ? 142.899 110.015 171.522 1.00 109.35 ? 664 GLN A NE2 1 
ATOM   4929 N N   . ARG A 1 639 ? 144.526 115.126 174.123 1.00 104.24 ? 665 ARG A N   1 
ATOM   4930 C CA  . ARG A 1 639 ? 144.592 116.305 173.267 1.00 104.35 ? 665 ARG A CA  1 
ATOM   4931 C C   . ARG A 1 639 ? 145.950 116.986 173.370 1.00 105.61 ? 665 ARG A C   1 
ATOM   4932 O O   . ARG A 1 639 ? 146.506 117.428 172.358 1.00 108.74 ? 665 ARG A O   1 
ATOM   4933 C CB  . ARG A 1 639 ? 143.470 117.279 173.627 1.00 106.75 ? 665 ARG A CB  1 
ATOM   4934 C CG  . ARG A 1 639 ? 143.305 118.428 172.647 1.00 108.72 ? 665 ARG A CG  1 
ATOM   4935 C CD  . ARG A 1 639 ? 142.139 119.321 173.039 1.00 109.71 ? 665 ARG A CD  1 
ATOM   4936 N NE  . ARG A 1 639 ? 141.885 120.359 172.046 1.00 110.57 ? 665 ARG A NE  1 
ATOM   4937 C CZ  . ARG A 1 639 ? 141.049 120.229 171.026 1.00 110.24 ? 665 ARG A CZ  1 
ATOM   4938 N NH1 . ARG A 1 639 ? 140.362 119.115 170.832 1.00 109.69 ? 665 ARG A NH1 1 
ATOM   4939 N NH2 . ARG A 1 639 ? 140.897 121.243 170.178 1.00 109.39 ? 665 ARG A NH2 1 
ATOM   4940 N N   . LEU A 1 640 ? 146.501 117.079 174.582 1.00 104.42 ? 666 LEU A N   1 
ATOM   4941 C CA  . LEU A 1 640 ? 147.822 117.678 174.745 1.00 106.35 ? 666 LEU A CA  1 
ATOM   4942 C C   . LEU A 1 640 ? 148.894 116.847 174.048 1.00 107.73 ? 666 LEU A C   1 
ATOM   4943 O O   . LEU A 1 640 ? 149.803 117.400 173.414 1.00 109.18 ? 666 LEU A O   1 
ATOM   4944 C CB  . LEU A 1 640 ? 148.146 117.841 176.229 1.00 105.89 ? 666 LEU A CB  1 
ATOM   4945 C CG  . LEU A 1 640 ? 149.436 118.594 176.557 1.00 105.78 ? 666 LEU A CG  1 
ATOM   4946 C CD1 . LEU A 1 640 ? 149.390 120.003 175.989 1.00 105.37 ? 666 LEU A CD1 1 
ATOM   4947 C CD2 . LEU A 1 640 ? 149.675 118.624 178.059 1.00 106.11 ? 666 LEU A CD2 1 
ATOM   4948 N N   . GLN A 1 641 ? 148.805 115.519 174.155 1.00 105.43 ? 667 GLN A N   1 
ATOM   4949 C CA  . GLN A 1 641 ? 149.757 114.661 173.455 1.00 102.06 ? 667 GLN A CA  1 
ATOM   4950 C C   . GLN A 1 641 ? 149.644 114.833 171.946 1.00 104.57 ? 667 GLN A C   1 
ATOM   4951 O O   . GLN A 1 641 ? 150.659 114.873 171.240 1.00 107.38 ? 667 GLN A O   1 
ATOM   4952 C CB  . GLN A 1 641 ? 149.539 113.200 173.847 1.00 103.67 ? 667 GLN A CB  1 
ATOM   4953 C CG  . GLN A 1 641 ? 149.860 112.890 175.298 1.00 106.79 ? 667 GLN A CG  1 
ATOM   4954 C CD  . GLN A 1 641 ? 149.633 111.432 175.643 1.00 107.20 ? 667 GLN A CD  1 
ATOM   4955 O OE1 . GLN A 1 641 ? 149.287 110.625 174.781 1.00 106.60 ? 667 GLN A OE1 1 
ATOM   4956 N NE2 . GLN A 1 641 ? 149.828 111.086 176.910 1.00 106.40 ? 667 GLN A NE2 1 
ATOM   4957 N N   . GLU A 1 642 ? 148.416 114.933 171.433 1.00 110.79 ? 668 GLU A N   1 
ATOM   4958 C CA  . GLU A 1 642 ? 148.225 115.155 170.003 1.00 112.42 ? 668 GLU A CA  1 
ATOM   4959 C C   . GLU A 1 642 ? 148.809 116.493 169.569 1.00 110.58 ? 668 GLU A C   1 
ATOM   4960 O O   . GLU A 1 642 ? 149.427 116.590 168.502 1.00 111.06 ? 668 GLU A O   1 
ATOM   4961 C CB  . GLU A 1 642 ? 146.739 115.079 169.653 1.00 111.89 ? 668 GLU A CB  1 
ATOM   4962 C CG  . GLU A 1 642 ? 146.437 115.288 168.178 1.00 112.14 ? 668 GLU A CG  1 
ATOM   4963 C CD  . GLU A 1 642 ? 144.955 115.212 167.869 1.00 112.63 ? 668 GLU A CD  1 
ATOM   4964 O OE1 . GLU A 1 642 ? 144.159 115.022 168.812 1.00 113.42 ? 668 GLU A OE1 1 
ATOM   4965 O OE2 . GLU A 1 642 ? 144.587 115.343 166.682 1.00 111.68 ? 668 GLU A OE2 1 
ATOM   4966 N N   . ILE A 1 643 ? 148.623 117.535 170.382 1.00 105.70 ? 669 ILE A N   1 
ATOM   4967 C CA  . ILE A 1 643 ? 149.182 118.844 170.057 1.00 104.53 ? 669 ILE A CA  1 
ATOM   4968 C C   . ILE A 1 643 ? 150.703 118.781 170.021 1.00 105.05 ? 669 ILE A C   1 
ATOM   4969 O O   . ILE A 1 643 ? 151.342 119.336 169.118 1.00 108.61 ? 669 ILE A O   1 
ATOM   4970 C CB  . ILE A 1 643 ? 148.681 119.904 171.056 1.00 107.36 ? 669 ILE A CB  1 
ATOM   4971 C CG1 . ILE A 1 643 ? 147.186 120.163 170.855 1.00 109.46 ? 669 ILE A CG1 1 
ATOM   4972 C CG2 . ILE A 1 643 ? 149.467 121.196 170.908 1.00 107.09 ? 669 ILE A CG2 1 
ATOM   4973 C CD1 . ILE A 1 643 ? 146.611 121.192 171.805 1.00 108.54 ? 669 ILE A CD1 1 
ATOM   4974 N N   . GLU A 1 644 ? 151.307 118.101 170.999 1.00 107.62 ? 670 GLU A N   1 
ATOM   4975 C CA  . GLU A 1 644 ? 152.762 117.982 171.020 1.00 109.36 ? 670 GLU A CA  1 
ATOM   4976 C C   . GLU A 1 644 ? 153.271 117.201 169.813 1.00 110.10 ? 670 GLU A C   1 
ATOM   4977 O O   . GLU A 1 644 ? 154.283 117.574 169.203 1.00 110.62 ? 670 GLU A O   1 
ATOM   4978 C CB  . GLU A 1 644 ? 153.215 117.320 172.320 1.00 110.55 ? 670 GLU A CB  1 
ATOM   4979 C CG  . GLU A 1 644 ? 154.723 117.189 172.460 1.00 112.02 ? 670 GLU A CG  1 
ATOM   4980 C CD  . GLU A 1 644 ? 155.134 116.549 173.771 1.00 113.06 ? 670 GLU A CD  1 
ATOM   4981 O OE1 . GLU A 1 644 ? 154.239 116.187 174.564 1.00 113.55 ? 670 GLU A OE1 1 
ATOM   4982 O OE2 . GLU A 1 644 ? 156.352 116.407 174.009 1.00 111.93 ? 670 GLU A OE2 1 
ATOM   4983 N N   . ARG A 1 645 ? 152.577 116.120 169.448 1.00 108.99 ? 671 ARG A N   1 
ATOM   4984 C CA  . ARG A 1 645 ? 152.966 115.348 168.273 1.00 108.49 ? 671 ARG A CA  1 
ATOM   4985 C C   . ARG A 1 645 ? 152.859 116.184 167.005 1.00 106.62 ? 671 ARG A C   1 
ATOM   4986 O O   . ARG A 1 645 ? 153.733 116.115 166.133 1.00 106.24 ? 671 ARG A O   1 
ATOM   4987 C CB  . ARG A 1 645 ? 152.103 114.092 168.164 1.00 109.26 ? 671 ARG A CB  1 
ATOM   4988 C CG  . ARG A 1 645 ? 152.375 113.253 166.928 1.00 109.51 ? 671 ARG A CG  1 
ATOM   4989 C CD  . ARG A 1 645 ? 151.448 112.050 166.865 1.00 110.66 ? 671 ARG A CD  1 
ATOM   4990 N NE  . ARG A 1 645 ? 151.678 111.244 165.672 1.00 112.41 ? 671 ARG A NE  1 
ATOM   4991 C CZ  . ARG A 1 645 ? 151.003 110.143 165.370 1.00 111.19 ? 671 ARG A CZ  1 
ATOM   4992 N NH1 . ARG A 1 645 ? 150.042 109.684 166.154 1.00 110.54 ? 671 ARG A NH1 1 
ATOM   4993 N NH2 . ARG A 1 645 ? 151.300 109.487 164.251 1.00 108.98 ? 671 ARG A NH2 1 
ATOM   4994 N N   . ARG A 1 646 ? 151.794 116.980 166.885 1.00 111.29 ? 672 ARG A N   1 
ATOM   4995 C CA  . ARG A 1 646 ? 151.645 117.858 165.729 1.00 112.18 ? 672 ARG A CA  1 
ATOM   4996 C C   . ARG A 1 646 ? 152.763 118.889 165.676 1.00 110.97 ? 672 ARG A C   1 
ATOM   4997 O O   . ARG A 1 646 ? 153.287 119.190 164.597 1.00 111.88 ? 672 ARG A O   1 
ATOM   4998 C CB  . ARG A 1 646 ? 150.280 118.545 165.768 1.00 113.81 ? 672 ARG A CB  1 
ATOM   4999 C CG  . ARG A 1 646 ? 150.073 119.589 164.682 1.00 114.24 ? 672 ARG A CG  1 
ATOM   5000 C CD  . ARG A 1 646 ? 148.759 120.330 164.874 1.00 113.57 ? 672 ARG A CD  1 
ATOM   5001 N NE  . ARG A 1 646 ? 148.586 121.397 163.895 1.00 115.91 ? 672 ARG A NE  1 
ATOM   5002 C CZ  . ARG A 1 646 ? 147.551 122.225 163.864 1.00 116.02 ? 672 ARG A CZ  1 
ATOM   5003 N NH1 . ARG A 1 646 ? 146.569 122.140 164.747 1.00 114.94 ? 672 ARG A NH1 1 
ATOM   5004 N NH2 . ARG A 1 646 ? 147.499 123.164 162.923 1.00 114.44 ? 672 ARG A NH2 1 
ATOM   5005 N N   . ARG A 1 647 ? 153.135 119.445 166.830 1.00 109.10 ? 673 ARG A N   1 
ATOM   5006 C CA  . ARG A 1 647 ? 154.233 120.406 166.867 1.00 108.99 ? 673 ARG A CA  1 
ATOM   5007 C C   . ARG A 1 647 ? 155.546 119.763 166.437 1.00 107.85 ? 673 ARG A C   1 
ATOM   5008 O O   . ARG A 1 647 ? 156.335 120.379 165.712 1.00 107.33 ? 673 ARG A O   1 
ATOM   5009 C CB  . ARG A 1 647 ? 154.359 121.008 168.266 1.00 110.73 ? 673 ARG A CB  1 
ATOM   5010 C CG  . ARG A 1 647 ? 153.198 121.907 168.657 1.00 111.79 ? 673 ARG A CG  1 
ATOM   5011 C CD  . ARG A 1 647 ? 153.359 122.439 170.071 1.00 111.79 ? 673 ARG A CD  1 
ATOM   5012 N NE  . ARG A 1 647 ? 152.239 123.284 170.467 1.00 111.97 ? 673 ARG A NE  1 
ATOM   5013 C CZ  . ARG A 1 647 ? 152.117 123.859 171.656 1.00 110.90 ? 673 ARG A CZ  1 
ATOM   5014 N NH1 . ARG A 1 647 ? 153.034 123.700 172.597 1.00 110.42 ? 673 ARG A NH1 1 
ATOM   5015 N NH2 . ARG A 1 647 ? 151.050 124.611 171.907 1.00 110.66 ? 673 ARG A NH2 1 
ATOM   5016 N N   . ASN A 1 648 ? 155.798 118.530 166.872 1.00 109.37 ? 674 ASN A N   1 
ATOM   5017 C CA  . ASN A 1 648 ? 157.018 117.815 166.489 1.00 109.08 ? 674 ASN A CA  1 
ATOM   5018 C C   . ASN A 1 648 ? 156.792 117.074 165.169 1.00 109.16 ? 674 ASN A C   1 
ATOM   5019 O O   . ASN A 1 648 ? 156.741 115.845 165.100 1.00 110.70 ? 674 ASN A O   1 
ATOM   5020 C CB  . ASN A 1 648 ? 157.450 116.867 167.600 1.00 111.25 ? 674 ASN A CB  1 
ATOM   5021 C CG  . ASN A 1 648 ? 157.804 117.595 168.882 1.00 111.83 ? 674 ASN A CG  1 
ATOM   5022 O OD1 . ASN A 1 648 ? 158.270 118.734 168.854 1.00 112.05 ? 674 ASN A OD1 1 
ATOM   5023 N ND2 . ASN A 1 648 ? 157.583 116.939 170.016 1.00 110.21 ? 674 ASN A ND2 1 
ATOM   5024 N N   . THR A 1 649 ? 156.658 117.860 164.100 1.00 107.79 ? 675 THR A N   1 
ATOM   5025 C CA  . THR A 1 649 ? 156.428 117.330 162.761 1.00 106.82 ? 675 THR A CA  1 
ATOM   5026 C C   . THR A 1 649 ? 157.387 117.991 161.778 1.00 104.85 ? 675 THR A C   1 
ATOM   5027 O O   . THR A 1 649 ? 157.470 119.231 161.732 1.00 106.86 ? 675 THR A O   1 
ATOM   5028 C CB  . THR A 1 649 ? 154.976 117.553 162.317 1.00 107.97 ? 675 THR A CB  1 
ATOM   5029 O OG1 . THR A 1 649 ? 154.088 116.915 163.243 1.00 110.00 ? 675 THR A OG1 1 
ATOM   5030 C CG2 . THR A 1 649 ? 154.750 116.980 160.927 1.00 105.21 ? 675 THR A CG2 1 
ATOM   5031 N N   . PRO A 1 650 ? 158.122 117.217 160.983 1.00 94.27  ? 676 PRO A N   1 
ATOM   5032 C CA  . PRO A 1 650 ? 159.050 117.814 160.015 1.00 98.14  ? 676 PRO A CA  1 
ATOM   5033 C C   . PRO A 1 650 ? 158.311 118.486 158.865 1.00 101.62 ? 676 PRO A C   1 
ATOM   5034 O O   . PRO A 1 650 ? 157.116 118.284 158.639 1.00 103.89 ? 676 PRO A O   1 
ATOM   5035 C CB  . PRO A 1 650 ? 159.876 116.620 159.531 1.00 97.41  ? 676 PRO A CB  1 
ATOM   5036 C CG  . PRO A 1 650 ? 158.996 115.440 159.761 1.00 97.81  ? 676 PRO A CG  1 
ATOM   5037 C CD  . PRO A 1 650 ? 158.205 115.747 160.997 1.00 94.25  ? 676 PRO A CD  1 
ATOM   5038 N N   . PHE A 1 651 ? 159.062 119.310 158.128 1.00 104.27 ? 677 PHE A N   1 
ATOM   5039 C CA  . PHE A 1 651 ? 158.474 120.127 157.070 1.00 104.32 ? 677 PHE A CA  1 
ATOM   5040 C C   . PHE A 1 651 ? 158.056 119.288 155.865 1.00 107.29 ? 677 PHE A C   1 
ATOM   5041 O O   . PHE A 1 651 ? 157.011 119.550 155.251 1.00 112.17 ? 677 PHE A O   1 
ATOM   5042 C CB  . PHE A 1 651 ? 159.465 121.213 156.652 1.00 103.30 ? 677 PHE A CB  1 
ATOM   5043 C CG  . PHE A 1 651 ? 159.043 121.990 155.438 1.00 107.21 ? 677 PHE A CG  1 
ATOM   5044 C CD1 . PHE A 1 651 ? 158.083 122.983 155.533 1.00 108.19 ? 677 PHE A CD1 1 
ATOM   5045 C CD2 . PHE A 1 651 ? 159.617 121.735 154.202 1.00 106.82 ? 677 PHE A CD2 1 
ATOM   5046 C CE1 . PHE A 1 651 ? 157.696 123.702 154.417 1.00 108.48 ? 677 PHE A CE1 1 
ATOM   5047 C CE2 . PHE A 1 651 ? 159.234 122.450 153.084 1.00 107.48 ? 677 PHE A CE2 1 
ATOM   5048 C CZ  . PHE A 1 651 ? 158.273 123.435 153.191 1.00 107.70 ? 677 PHE A CZ  1 
ATOM   5049 N N   . HIS A 1 652 ? 158.861 118.286 155.503 1.00 94.24  ? 678 HIS A N   1 
ATOM   5050 C CA  . HIS A 1 652 ? 158.576 117.517 154.296 1.00 94.44  ? 678 HIS A CA  1 
ATOM   5051 C C   . HIS A 1 652 ? 157.273 116.738 154.417 1.00 95.45  ? 678 HIS A C   1 
ATOM   5052 O O   . HIS A 1 652 ? 156.545 116.596 153.427 1.00 100.16 ? 678 HIS A O   1 
ATOM   5053 C CB  . HIS A 1 652 ? 159.738 116.576 153.981 1.00 93.89  ? 678 HIS A CB  1 
ATOM   5054 C CG  . HIS A 1 652 ? 160.020 115.577 155.058 1.00 95.55  ? 678 HIS A CG  1 
ATOM   5055 N ND1 . HIS A 1 652 ? 159.388 114.354 155.122 1.00 97.49  ? 678 HIS A ND1 1 
ATOM   5056 C CD2 . HIS A 1 652 ? 160.869 115.618 156.111 1.00 96.29  ? 678 HIS A CD2 1 
ATOM   5057 C CE1 . HIS A 1 652 ? 159.835 113.685 156.169 1.00 97.39  ? 678 HIS A CE1 1 
ATOM   5058 N NE2 . HIS A 1 652 ? 160.734 114.429 156.787 1.00 97.89  ? 678 HIS A NE2 1 
ATOM   5059 N N   . GLU A 1 653 ? 156.956 116.236 155.613 1.00 89.33  ? 679 GLU A N   1 
ATOM   5060 C CA  . GLU A 1 653 ? 155.674 115.568 155.807 1.00 91.82  ? 679 GLU A CA  1 
ATOM   5061 C C   . GLU A 1 653 ? 154.515 116.533 155.591 1.00 92.78  ? 679 GLU A C   1 
ATOM   5062 O O   . GLU A 1 653 ? 153.498 116.166 154.991 1.00 98.58  ? 679 GLU A O   1 
ATOM   5063 C CB  . GLU A 1 653 ? 155.608 114.948 157.202 1.00 95.75  ? 679 GLU A CB  1 
ATOM   5064 C CG  . GLU A 1 653 ? 156.606 113.824 157.430 1.00 98.64  ? 679 GLU A CG  1 
ATOM   5065 C CD  . GLU A 1 653 ? 156.478 113.201 158.806 1.00 99.73  ? 679 GLU A CD  1 
ATOM   5066 O OE1 . GLU A 1 653 ? 155.637 113.674 159.599 1.00 99.43  ? 679 GLU A OE1 1 
ATOM   5067 O OE2 . GLU A 1 653 ? 157.220 112.238 159.096 1.00 98.00  ? 679 GLU A OE2 1 
ATOM   5068 N N   . ARG A 1 654 ? 154.655 117.773 156.065 1.00 85.78  ? 680 ARG A N   1 
ATOM   5069 C CA  . ARG A 1 654 ? 153.605 118.764 155.855 1.00 89.21  ? 680 ARG A CA  1 
ATOM   5070 C C   . ARG A 1 654 ? 153.439 119.083 154.374 1.00 91.33  ? 680 ARG A C   1 
ATOM   5071 O O   . ARG A 1 654 ? 152.309 119.204 153.881 1.00 94.53  ? 680 ARG A O   1 
ATOM   5072 C CB  . ARG A 1 654 ? 153.915 120.033 156.647 1.00 89.98  ? 680 ARG A CB  1 
ATOM   5073 C CG  . ARG A 1 654 ? 154.183 119.792 158.122 1.00 92.46  ? 680 ARG A CG  1 
ATOM   5074 C CD  . ARG A 1 654 ? 154.388 121.096 158.880 1.00 92.31  ? 680 ARG A CD  1 
ATOM   5075 N NE  . ARG A 1 654 ? 153.154 121.862 159.010 1.00 95.71  ? 680 ARG A NE  1 
ATOM   5076 C CZ  . ARG A 1 654 ? 152.818 122.884 158.235 1.00 96.46  ? 680 ARG A CZ  1 
ATOM   5077 N NH1 . ARG A 1 654 ? 153.608 123.302 157.260 1.00 94.57  ? 680 ARG A NH1 1 
ATOM   5078 N NH2 . ARG A 1 654 ? 151.660 123.504 158.445 1.00 95.58  ? 680 ARG A NH2 1 
ATOM   5079 N N   . PHE A 1 655 ? 154.552 119.212 153.649 1.00 81.80  ? 681 PHE A N   1 
ATOM   5080 C CA  . PHE A 1 655 ? 154.469 119.470 152.214 1.00 81.99  ? 681 PHE A CA  1 
ATOM   5081 C C   . PHE A 1 655 ? 153.792 118.313 151.487 1.00 85.26  ? 681 PHE A C   1 
ATOM   5082 O O   . PHE A 1 655 ? 152.955 118.526 150.597 1.00 89.22  ? 681 PHE A O   1 
ATOM   5083 C CB  . PHE A 1 655 ? 155.870 119.718 151.654 1.00 82.99  ? 681 PHE A CB  1 
ATOM   5084 C CG  . PHE A 1 655 ? 155.882 120.254 150.251 1.00 86.17  ? 681 PHE A CG  1 
ATOM   5085 C CD1 . PHE A 1 655 ? 155.648 121.596 150.007 1.00 86.51  ? 681 PHE A CD1 1 
ATOM   5086 C CD2 . PHE A 1 655 ? 156.146 119.419 149.179 1.00 85.36  ? 681 PHE A CD2 1 
ATOM   5087 C CE1 . PHE A 1 655 ? 155.664 122.095 148.719 1.00 85.94  ? 681 PHE A CE1 1 
ATOM   5088 C CE2 . PHE A 1 655 ? 156.165 119.912 147.888 1.00 85.59  ? 681 PHE A CE2 1 
ATOM   5089 C CZ  . PHE A 1 655 ? 155.923 121.252 147.658 1.00 85.82  ? 681 PHE A CZ  1 
ATOM   5090 N N   . PHE A 1 656 ? 154.129 117.079 151.869 1.00 75.67  ? 682 PHE A N   1 
ATOM   5091 C CA  . PHE A 1 656 ? 153.521 115.912 151.239 1.00 72.75  ? 682 PHE A CA  1 
ATOM   5092 C C   . PHE A 1 656 ? 152.025 115.849 151.522 1.00 75.55  ? 682 PHE A C   1 
ATOM   5093 O O   . PHE A 1 656 ? 151.230 115.533 150.627 1.00 84.37  ? 682 PHE A O   1 
ATOM   5094 C CB  . PHE A 1 656 ? 154.220 114.642 151.720 1.00 74.37  ? 682 PHE A CB  1 
ATOM   5095 C CG  . PHE A 1 656 ? 153.941 113.436 150.874 1.00 78.62  ? 682 PHE A CG  1 
ATOM   5096 C CD1 . PHE A 1 656 ? 154.597 113.253 149.670 1.00 78.50  ? 682 PHE A CD1 1 
ATOM   5097 C CD2 . PHE A 1 656 ? 153.031 112.479 151.288 1.00 80.54  ? 682 PHE A CD2 1 
ATOM   5098 C CE1 . PHE A 1 656 ? 154.345 112.142 148.889 1.00 79.36  ? 682 PHE A CE1 1 
ATOM   5099 C CE2 . PHE A 1 656 ? 152.775 111.364 150.513 1.00 80.41  ? 682 PHE A CE2 1 
ATOM   5100 C CZ  . PHE A 1 656 ? 153.433 111.196 149.312 1.00 80.44  ? 682 PHE A CZ  1 
ATOM   5101 N N   . ARG A 1 657 ? 151.620 116.152 152.758 1.00 75.11  ? 683 ARG A N   1 
ATOM   5102 C CA  . ARG A 1 657 ? 150.198 116.156 153.086 1.00 78.38  ? 683 ARG A CA  1 
ATOM   5103 C C   . ARG A 1 657 ? 149.455 117.240 152.314 1.00 82.61  ? 683 ARG A C   1 
ATOM   5104 O O   . ARG A 1 657 ? 148.328 117.020 151.853 1.00 87.98  ? 683 ARG A O   1 
ATOM   5105 C CB  . ARG A 1 657 ? 150.004 116.337 154.590 1.00 81.09  ? 683 ARG A CB  1 
ATOM   5106 C CG  . ARG A 1 657 ? 150.470 115.151 155.419 1.00 85.30  ? 683 ARG A CG  1 
ATOM   5107 C CD  . ARG A 1 657 ? 150.218 115.376 156.900 1.00 85.19  ? 683 ARG A CD  1 
ATOM   5108 N NE  . ARG A 1 657 ? 150.646 114.237 157.703 1.00 85.86  ? 683 ARG A NE  1 
ATOM   5109 C CZ  . ARG A 1 657 ? 150.498 114.148 159.017 1.00 85.77  ? 683 ARG A CZ  1 
ATOM   5110 N NH1 . ARG A 1 657 ? 149.932 115.119 159.716 1.00 84.92  ? 683 ARG A NH1 1 
ATOM   5111 N NH2 . ARG A 1 657 ? 150.926 113.058 159.647 1.00 85.90  ? 683 ARG A NH2 1 
ATOM   5112 N N   . PHE A 1 658 ? 150.070 118.416 152.163 1.00 71.96  ? 684 PHE A N   1 
ATOM   5113 C CA  . PHE A 1 658 ? 149.452 119.481 151.379 1.00 70.91  ? 684 PHE A CA  1 
ATOM   5114 C C   . PHE A 1 658 ? 149.244 119.049 149.932 1.00 73.50  ? 684 PHE A C   1 
ATOM   5115 O O   . PHE A 1 658 ? 148.162 119.255 149.356 1.00 76.92  ? 684 PHE A O   1 
ATOM   5116 C CB  . PHE A 1 658 ? 150.322 120.737 151.455 1.00 69.88  ? 684 PHE A CB  1 
ATOM   5117 C CG  . PHE A 1 658 ? 149.831 121.877 150.611 1.00 72.95  ? 684 PHE A CG  1 
ATOM   5118 C CD1 . PHE A 1 658 ? 148.846 122.727 151.079 1.00 73.34  ? 684 PHE A CD1 1 
ATOM   5119 C CD2 . PHE A 1 658 ? 150.374 122.114 149.360 1.00 72.96  ? 684 PHE A CD2 1 
ATOM   5120 C CE1 . PHE A 1 658 ? 148.399 123.781 150.310 1.00 74.30  ? 684 PHE A CE1 1 
ATOM   5121 C CE2 . PHE A 1 658 ? 149.932 123.166 148.586 1.00 72.33  ? 684 PHE A CE2 1 
ATOM   5122 C CZ  . PHE A 1 658 ? 148.943 124.001 149.062 1.00 74.18  ? 684 PHE A CZ  1 
ATOM   5123 N N   . LEU A 1 659 ? 150.264 118.429 149.335 1.00 69.26  ? 685 LEU A N   1 
ATOM   5124 C CA  . LEU A 1 659 ? 150.138 117.978 147.953 1.00 70.29  ? 685 LEU A CA  1 
ATOM   5125 C C   . LEU A 1 659 ? 149.072 116.897 147.818 1.00 70.39  ? 685 LEU A C   1 
ATOM   5126 O O   . LEU A 1 659 ? 148.299 116.896 146.850 1.00 77.27  ? 685 LEU A O   1 
ATOM   5127 C CB  . LEU A 1 659 ? 151.486 117.478 147.437 1.00 70.40  ? 685 LEU A CB  1 
ATOM   5128 C CG  . LEU A 1 659 ? 152.342 118.498 146.682 1.00 73.46  ? 685 LEU A CG  1 
ATOM   5129 C CD1 . LEU A 1 659 ? 151.649 118.924 145.399 1.00 72.47  ? 685 LEU A CD1 1 
ATOM   5130 C CD2 . LEU A 1 659 ? 152.654 119.710 147.544 1.00 73.53  ? 685 LEU A CD2 1 
ATOM   5131 N N   . LEU A 1 660 ? 149.004 115.978 148.784 1.00 62.36  ? 686 LEU A N   1 
ATOM   5132 C CA  . LEU A 1 660 ? 147.988 114.932 148.733 1.00 62.98  ? 686 LEU A CA  1 
ATOM   5133 C C   . LEU A 1 660 ? 146.585 115.516 148.844 1.00 66.62  ? 686 LEU A C   1 
ATOM   5134 O O   . LEU A 1 660 ? 145.667 115.077 148.139 1.00 74.92  ? 686 LEU A O   1 
ATOM   5135 C CB  . LEU A 1 660 ? 148.232 113.908 149.838 1.00 63.01  ? 686 LEU A CB  1 
ATOM   5136 C CG  . LEU A 1 660 ? 148.803 112.564 149.386 1.00 66.96  ? 686 LEU A CG  1 
ATOM   5137 C CD1 . LEU A 1 660 ? 150.093 112.765 148.610 1.00 66.99  ? 686 LEU A CD1 1 
ATOM   5138 C CD2 . LEU A 1 660 ? 149.026 111.646 150.577 1.00 67.17  ? 686 LEU A CD2 1 
ATOM   5139 N N   . ARG A 1 661 ? 146.399 116.502 149.723 1.00 62.66  ? 687 ARG A N   1 
ATOM   5140 C CA  . ARG A 1 661 ? 145.089 117.130 149.860 1.00 64.85  ? 687 ARG A CA  1 
ATOM   5141 C C   . ARG A 1 661 ? 144.673 117.830 148.571 1.00 70.29  ? 687 ARG A C   1 
ATOM   5142 O O   . ARG A 1 661 ? 143.517 117.713 148.134 1.00 73.65  ? 687 ARG A O   1 
ATOM   5143 C CB  . ARG A 1 661 ? 145.105 118.108 151.033 1.00 65.34  ? 687 ARG A CB  1 
ATOM   5144 C CG  . ARG A 1 661 ? 143.780 118.794 151.298 1.00 70.48  ? 687 ARG A CG  1 
ATOM   5145 C CD  . ARG A 1 661 ? 143.772 119.498 152.650 1.00 71.41  ? 687 ARG A CD  1 
ATOM   5146 N NE  . ARG A 1 661 ? 144.813 120.514 152.762 1.00 76.83  ? 687 ARG A NE  1 
ATOM   5147 C CZ  . ARG A 1 661 ? 145.946 120.358 153.434 1.00 77.96  ? 687 ARG A CZ  1 
ATOM   5148 N NH1 . ARG A 1 661 ? 146.221 119.233 154.075 1.00 74.95  ? 687 ARG A NH1 1 
ATOM   5149 N NH2 . ARG A 1 661 ? 146.824 121.356 153.466 1.00 75.03  ? 687 ARG A NH2 1 
ATOM   5150 N N   . LYS A 1 662 ? 145.603 118.549 147.938 1.00 60.26  ? 688 LYS A N   1 
ATOM   5151 C CA  . LYS A 1 662 ? 145.265 119.206 146.678 1.00 56.14  ? 688 LYS A CA  1 
ATOM   5152 C C   . LYS A 1 662 ? 144.935 118.188 145.591 1.00 57.59  ? 688 LYS A C   1 
ATOM   5153 O O   . LYS A 1 662 ? 143.999 118.391 144.802 1.00 67.10  ? 688 LYS A O   1 
ATOM   5154 C CB  . LYS A 1 662 ? 146.406 120.118 146.237 1.00 55.95  ? 688 LYS A CB  1 
ATOM   5155 C CG  . LYS A 1 662 ? 146.547 121.360 147.091 1.00 56.55  ? 688 LYS A CG  1 
ATOM   5156 C CD  . LYS A 1 662 ? 145.247 122.140 147.129 1.00 55.56  ? 688 LYS A CD  1 
ATOM   5157 C CE  . LYS A 1 662 ? 145.350 123.343 148.044 1.00 60.22  ? 688 LYS A CE  1 
ATOM   5158 N NZ  . LYS A 1 662 ? 144.070 124.094 148.113 1.00 62.72  ? 688 LYS A NZ  1 
ATOM   5159 N N   . LEU A 1 663 ? 145.682 117.082 145.539 1.00 58.90  ? 689 LEU A N   1 
ATOM   5160 C CA  . LEU A 1 663 ? 145.389 116.045 144.556 1.00 59.85  ? 689 LEU A CA  1 
ATOM   5161 C C   . LEU A 1 663 ? 144.007 115.449 144.786 1.00 59.89  ? 689 LEU A C   1 
ATOM   5162 O O   . LEU A 1 663 ? 143.275 115.171 143.828 1.00 63.36  ? 689 LEU A O   1 
ATOM   5163 C CB  . LEU A 1 663 ? 146.458 114.955 144.606 1.00 61.80  ? 689 LEU A CB  1 
ATOM   5164 C CG  . LEU A 1 663 ? 146.238 113.758 143.681 1.00 62.84  ? 689 LEU A CG  1 
ATOM   5165 C CD1 . LEU A 1 663 ? 146.161 114.208 142.232 1.00 61.73  ? 689 LEU A CD1 1 
ATOM   5166 C CD2 . LEU A 1 663 ? 147.340 112.728 143.869 1.00 61.89  ? 689 LEU A CD2 1 
ATOM   5167 N N   . TYR A 1 664 ? 143.633 115.250 146.052 1.00 65.82  ? 690 TYR A N   1 
ATOM   5168 C CA  . TYR A 1 664 ? 142.300 114.742 146.354 1.00 65.03  ? 690 TYR A CA  1 
ATOM   5169 C C   . TYR A 1 664 ? 141.223 115.711 145.889 1.00 66.05  ? 690 TYR A C   1 
ATOM   5170 O O   . TYR A 1 664 ? 140.201 115.292 145.329 1.00 72.44  ? 690 TYR A O   1 
ATOM   5171 C CB  . TYR A 1 664 ? 142.164 114.474 147.851 1.00 68.42  ? 690 TYR A CB  1 
ATOM   5172 C CG  . TYR A 1 664 ? 140.735 114.308 148.314 1.00 70.90  ? 690 TYR A CG  1 
ATOM   5173 C CD1 . TYR A 1 664 ? 140.029 113.144 148.045 1.00 72.03  ? 690 TYR A CD1 1 
ATOM   5174 C CD2 . TYR A 1 664 ? 140.095 115.312 149.027 1.00 71.30  ? 690 TYR A CD2 1 
ATOM   5175 C CE1 . TYR A 1 664 ? 138.723 112.989 148.468 1.00 71.99  ? 690 TYR A CE1 1 
ATOM   5176 C CE2 . TYR A 1 664 ? 138.791 115.165 149.454 1.00 71.69  ? 690 TYR A CE2 1 
ATOM   5177 C CZ  . TYR A 1 664 ? 138.110 114.002 149.173 1.00 73.18  ? 690 TYR A CZ  1 
ATOM   5178 O OH  . TYR A 1 664 ? 136.810 113.852 149.597 1.00 73.86  ? 690 TYR A OH  1 
ATOM   5179 N N   . VAL A 1 665 ? 141.435 117.011 146.107 1.00 58.26  ? 691 VAL A N   1 
ATOM   5180 C CA  . VAL A 1 665 ? 140.450 118.001 145.669 1.00 56.23  ? 691 VAL A CA  1 
ATOM   5181 C C   . VAL A 1 665 ? 140.276 117.942 144.156 1.00 57.97  ? 691 VAL A C   1 
ATOM   5182 O O   . VAL A 1 665 ? 139.148 117.902 143.638 1.00 62.82  ? 691 VAL A O   1 
ATOM   5183 C CB  . VAL A 1 665 ? 140.859 119.411 146.133 1.00 51.33  ? 691 VAL A CB  1 
ATOM   5184 C CG1 . VAL A 1 665 ? 139.930 120.451 145.536 1.00 48.78  ? 691 VAL A CG1 1 
ATOM   5185 C CG2 . VAL A 1 665 ? 140.845 119.495 147.648 1.00 56.72  ? 691 VAL A CG2 1 
ATOM   5186 N N   . PHE A 1 666 ? 141.393 117.911 143.424 1.00 50.75  ? 692 PHE A N   1 
ATOM   5187 C CA  . PHE A 1 666 ? 141.311 117.889 141.965 1.00 47.58  ? 692 PHE A CA  1 
ATOM   5188 C C   . PHE A 1 666 ? 140.640 116.613 141.463 1.00 52.95  ? 692 PHE A C   1 
ATOM   5189 O O   . PHE A 1 666 ? 139.810 116.659 140.542 1.00 60.64  ? 692 PHE A O   1 
ATOM   5190 C CB  . PHE A 1 666 ? 142.706 118.039 141.357 1.00 45.06  ? 692 PHE A CB  1 
ATOM   5191 C CG  . PHE A 1 666 ? 143.171 119.464 141.248 1.00 46.16  ? 692 PHE A CG  1 
ATOM   5192 C CD1 . PHE A 1 666 ? 143.821 120.080 142.300 1.00 47.64  ? 692 PHE A CD1 1 
ATOM   5193 C CD2 . PHE A 1 666 ? 142.959 120.186 140.089 1.00 52.13  ? 692 PHE A CD2 1 
ATOM   5194 C CE1 . PHE A 1 666 ? 144.249 121.387 142.201 1.00 46.58  ? 692 PHE A CE1 1 
ATOM   5195 C CE2 . PHE A 1 666 ? 143.386 121.494 139.984 1.00 52.61  ? 692 PHE A CE2 1 
ATOM   5196 C CZ  . PHE A 1 666 ? 144.031 122.094 141.042 1.00 50.65  ? 692 PHE A CZ  1 
ATOM   5197 N N   . ARG A 1 667 ? 140.978 115.468 142.060 1.00 47.07  ? 693 ARG A N   1 
ATOM   5198 C CA  . ARG A 1 667 ? 140.388 114.208 141.624 1.00 46.08  ? 693 ARG A CA  1 
ATOM   5199 C C   . ARG A 1 667 ? 138.890 114.177 141.890 1.00 46.47  ? 693 ARG A C   1 
ATOM   5200 O O   . ARG A 1 667 ? 138.115 113.704 141.048 1.00 55.24  ? 693 ARG A O   1 
ATOM   5201 C CB  . ARG A 1 667 ? 141.079 113.037 142.317 1.00 51.04  ? 693 ARG A CB  1 
ATOM   5202 C CG  . ARG A 1 667 ? 140.923 111.716 141.591 1.00 52.53  ? 693 ARG A CG  1 
ATOM   5203 C CD  . ARG A 1 667 ? 141.538 110.581 142.382 1.00 47.80  ? 693 ARG A CD  1 
ATOM   5204 N NE  . ARG A 1 667 ? 140.757 110.276 143.573 1.00 43.40  ? 693 ARG A NE  1 
ATOM   5205 C CZ  . ARG A 1 667 ? 139.778 109.384 143.612 1.00 47.72  ? 693 ARG A CZ  1 
ATOM   5206 N NH1 . ARG A 1 667 ? 139.438 108.684 142.543 1.00 46.63  ? 693 ARG A NH1 1 
ATOM   5207 N NH2 . ARG A 1 667 ? 139.125 109.188 144.754 1.00 54.32  ? 693 ARG A NH2 1 
ATOM   5208 N N   . ARG A 1 668 ? 138.461 114.672 143.054 1.00 47.40  ? 694 ARG A N   1 
ATOM   5209 C CA  . ARG A 1 668 ? 137.033 114.711 143.347 1.00 49.48  ? 694 ARG A CA  1 
ATOM   5210 C C   . ARG A 1 668 ? 136.300 115.616 142.368 1.00 51.15  ? 694 ARG A C   1 
ATOM   5211 O O   . ARG A 1 668 ? 135.210 115.270 141.892 1.00 60.69  ? 694 ARG A O   1 
ATOM   5212 C CB  . ARG A 1 668 ? 136.797 115.173 144.783 1.00 51.61  ? 694 ARG A CB  1 
ATOM   5213 C CG  . ARG A 1 668 ? 135.350 115.064 145.228 1.00 55.39  ? 694 ARG A CG  1 
ATOM   5214 C CD  . ARG A 1 668 ? 135.149 115.612 146.627 1.00 55.46  ? 694 ARG A CD  1 
ATOM   5215 N NE  . ARG A 1 668 ? 133.821 115.302 147.142 1.00 53.80  ? 694 ARG A NE  1 
ATOM   5216 C CZ  . ARG A 1 668 ? 132.732 116.013 146.883 1.00 55.31  ? 694 ARG A CZ  1 
ATOM   5217 N NH1 . ARG A 1 668 ? 132.774 117.085 146.111 1.00 54.57  ? 694 ARG A NH1 1 
ATOM   5218 N NH2 . ARG A 1 668 ? 131.572 115.637 147.412 1.00 58.13  ? 694 ARG A NH2 1 
ATOM   5219 N N   . SER A 1 669 ? 136.889 116.772 142.045 1.00 41.80  ? 695 SER A N   1 
ATOM   5220 C CA  . SER A 1 669 ? 136.269 117.661 141.067 1.00 43.03  ? 695 SER A CA  1 
ATOM   5221 C C   . SER A 1 669 ? 136.089 116.956 139.728 1.00 48.73  ? 695 SER A C   1 
ATOM   5222 O O   . SER A 1 669 ? 134.997 116.973 139.141 1.00 56.02  ? 695 SER A O   1 
ATOM   5223 C CB  . SER A 1 669 ? 137.111 118.924 140.901 1.00 43.97  ? 695 SER A CB  1 
ATOM   5224 O OG  . SER A 1 669 ? 137.249 119.610 142.133 1.00 56.63  ? 695 SER A OG  1 
ATOM   5225 N N   . PHE A 1 670 ? 137.152 116.308 139.241 1.00 49.27  ? 696 PHE A N   1 
ATOM   5226 C CA  . PHE A 1 670 ? 137.078 115.644 137.943 1.00 45.89  ? 696 PHE A CA  1 
ATOM   5227 C C   . PHE A 1 670 ? 136.038 114.530 137.943 1.00 49.42  ? 696 PHE A C   1 
ATOM   5228 O O   . PHE A 1 670 ? 135.244 114.414 137.000 1.00 52.38  ? 696 PHE A O   1 
ATOM   5229 C CB  . PHE A 1 670 ? 138.450 115.093 137.560 1.00 45.34  ? 696 PHE A CB  1 
ATOM   5230 C CG  . PHE A 1 670 ? 138.451 114.297 136.287 1.00 47.33  ? 696 PHE A CG  1 
ATOM   5231 C CD1 . PHE A 1 670 ? 138.485 114.932 135.060 1.00 51.92  ? 696 PHE A CD1 1 
ATOM   5232 C CD2 . PHE A 1 670 ? 138.434 112.913 136.318 1.00 49.95  ? 696 PHE A CD2 1 
ATOM   5233 C CE1 . PHE A 1 670 ? 138.493 114.204 133.888 1.00 51.91  ? 696 PHE A CE1 1 
ATOM   5234 C CE2 . PHE A 1 670 ? 138.442 112.180 135.148 1.00 52.73  ? 696 PHE A CE2 1 
ATOM   5235 C CZ  . PHE A 1 670 ? 138.473 112.827 133.933 1.00 51.23  ? 696 PHE A CZ  1 
ATOM   5236 N N   . LEU A 1 671 ? 136.021 113.706 138.993 1.00 47.65  ? 697 LEU A N   1 
ATOM   5237 C CA  . LEU A 1 671 ? 135.095 112.579 139.023 1.00 40.43  ? 697 LEU A CA  1 
ATOM   5238 C C   . LEU A 1 671 ? 133.647 113.048 139.098 1.00 50.45  ? 697 LEU A C   1 
ATOM   5239 O O   . LEU A 1 671 ? 132.777 112.504 138.403 1.00 62.72  ? 697 LEU A O   1 
ATOM   5240 C CB  . LEU A 1 671 ? 135.427 111.655 140.192 1.00 45.36  ? 697 LEU A CB  1 
ATOM   5241 C CG  . LEU A 1 671 ? 136.342 110.471 139.877 1.00 48.86  ? 697 LEU A CG  1 
ATOM   5242 C CD1 . LEU A 1 671 ? 135.710 109.587 138.818 1.00 50.81  ? 697 LEU A CD1 1 
ATOM   5243 C CD2 . LEU A 1 671 ? 137.718 110.932 139.433 1.00 49.59  ? 697 LEU A CD2 1 
ATOM   5244 N N   . MET A 1 672 ? 133.362 114.054 139.932 1.00 52.26  ? 698 MET A N   1 
ATOM   5245 C CA  . MET A 1 672 ? 131.992 114.550 140.017 1.00 51.28  ? 698 MET A CA  1 
ATOM   5246 C C   . MET A 1 672 ? 131.549 115.170 138.698 1.00 52.52  ? 698 MET A C   1 
ATOM   5247 O O   . MET A 1 672 ? 130.403 114.978 138.269 1.00 57.89  ? 698 MET A O   1 
ATOM   5248 C CB  . MET A 1 672 ? 131.861 115.557 141.158 1.00 49.18  ? 698 MET A CB  1 
ATOM   5249 C CG  . MET A 1 672 ? 132.114 114.971 142.538 1.00 54.68  ? 698 MET A CG  1 
ATOM   5250 S SD  . MET A 1 672 ? 131.030 113.588 142.936 1.00 65.37  ? 698 MET A SD  1 
ATOM   5251 C CE  . MET A 1 672 ? 129.430 114.389 142.900 1.00 52.87  ? 698 MET A CE  1 
ATOM   5252 N N   . THR A 1 673 ? 132.445 115.905 138.031 1.00 48.27  ? 699 THR A N   1 
ATOM   5253 C CA  . THR A 1 673 ? 132.091 116.478 136.737 1.00 44.11  ? 699 THR A CA  1 
ATOM   5254 C C   . THR A 1 673 ? 131.798 115.389 135.712 1.00 44.17  ? 699 THR A C   1 
ATOM   5255 O O   . THR A 1 673 ? 130.845 115.506 134.929 1.00 54.60  ? 699 THR A O   1 
ATOM   5256 C CB  . THR A 1 673 ? 133.210 117.394 136.245 1.00 50.07  ? 699 THR A CB  1 
ATOM   5257 O OG1 . THR A 1 673 ? 133.445 118.423 137.215 1.00 54.37  ? 699 THR A OG1 1 
ATOM   5258 C CG2 . THR A 1 673 ? 132.829 118.035 134.924 1.00 50.30  ? 699 THR A CG2 1 
ATOM   5259 N N   . CYS A 1 674 ? 132.598 114.319 135.704 1.00 45.97  ? 700 CYS A N   1 
ATOM   5260 C CA  . CYS A 1 674 ? 132.351 113.230 134.763 1.00 49.35  ? 700 CYS A CA  1 
ATOM   5261 C C   . CYS A 1 674 ? 131.019 112.545 135.040 1.00 55.49  ? 700 CYS A C   1 
ATOM   5262 O O   . CYS A 1 674 ? 130.275 112.221 134.104 1.00 62.62  ? 700 CYS A O   1 
ATOM   5263 C CB  . CYS A 1 674 ? 133.494 112.219 134.812 1.00 50.58  ? 700 CYS A CB  1 
ATOM   5264 S SG  . CYS A 1 674 ? 135.054 112.845 134.158 1.00 76.53  ? 700 CYS A SG  1 
ATOM   5265 N N   . ILE A 1 675 ? 130.694 112.324 136.317 1.00 51.22  ? 701 ILE A N   1 
ATOM   5266 C CA  . ILE A 1 675 ? 129.416 111.697 136.653 1.00 43.72  ? 701 ILE A CA  1 
ATOM   5267 C C   . ILE A 1 675 ? 128.257 112.575 136.198 1.00 50.60  ? 701 ILE A C   1 
ATOM   5268 O O   . ILE A 1 675 ? 127.273 112.086 135.624 1.00 55.62  ? 701 ILE A O   1 
ATOM   5269 C CB  . ILE A 1 675 ? 129.341 111.402 138.161 1.00 39.03  ? 701 ILE A CB  1 
ATOM   5270 C CG1 . ILE A 1 675 ? 130.417 110.393 138.560 1.00 50.29  ? 701 ILE A CG1 1 
ATOM   5271 C CG2 . ILE A 1 675 ? 127.969 110.872 138.528 1.00 43.88  ? 701 ILE A CG2 1 
ATOM   5272 C CD1 . ILE A 1 675 ? 130.479 110.124 140.045 1.00 53.15  ? 701 ILE A CD1 1 
ATOM   5273 N N   . SER A 1 676 ? 128.358 113.885 136.433 1.00 53.49  ? 702 SER A N   1 
ATOM   5274 C CA  . SER A 1 676 ? 127.285 114.787 136.027 1.00 45.20  ? 702 SER A CA  1 
ATOM   5275 C C   . SER A 1 676 ? 127.125 114.820 134.512 1.00 42.69  ? 702 SER A C   1 
ATOM   5276 O O   . SER A 1 676 ? 125.997 114.818 133.999 1.00 51.88  ? 702 SER A O   1 
ATOM   5277 C CB  . SER A 1 676 ? 127.552 116.189 136.564 1.00 53.21  ? 702 SER A CB  1 
ATOM   5278 O OG  . SER A 1 676 ? 126.639 117.122 136.017 1.00 57.64  ? 702 SER A OG  1 
ATOM   5279 N N   . LEU A 1 677 ? 128.237 114.848 133.777 1.00 40.72  ? 703 LEU A N   1 
ATOM   5280 C CA  . LEU A 1 677 ? 128.139 114.879 132.322 1.00 46.69  ? 703 LEU A CA  1 
ATOM   5281 C C   . LEU A 1 677 ? 127.555 113.579 131.781 1.00 49.92  ? 703 LEU A C   1 
ATOM   5282 O O   . LEU A 1 677 ? 126.768 113.598 130.826 1.00 60.37  ? 703 LEU A O   1 
ATOM   5283 C CB  . LEU A 1 677 ? 129.508 115.161 131.705 1.00 49.94  ? 703 LEU A CB  1 
ATOM   5284 C CG  . LEU A 1 677 ? 130.011 116.599 131.846 1.00 47.85  ? 703 LEU A CG  1 
ATOM   5285 C CD1 . LEU A 1 677 ? 131.380 116.753 131.204 1.00 50.24  ? 703 LEU A CD1 1 
ATOM   5286 C CD2 . LEU A 1 677 ? 129.019 117.570 131.235 1.00 45.32  ? 703 LEU A CD2 1 
ATOM   5287 N N   . ARG A 1 678 ? 127.920 112.441 132.379 1.00 46.89  ? 704 ARG A N   1 
ATOM   5288 C CA  . ARG A 1 678 ? 127.309 111.184 131.962 1.00 47.31  ? 704 ARG A CA  1 
ATOM   5289 C C   . ARG A 1 678 ? 125.814 111.172 132.242 1.00 50.29  ? 704 ARG A C   1 
ATOM   5290 O O   . ARG A 1 678 ? 125.037 110.668 131.423 1.00 57.17  ? 704 ARG A O   1 
ATOM   5291 C CB  . ARG A 1 678 ? 127.971 110.000 132.660 1.00 51.41  ? 704 ARG A CB  1 
ATOM   5292 C CG  . ARG A 1 678 ? 127.432 108.662 132.187 1.00 52.75  ? 704 ARG A CG  1 
ATOM   5293 C CD  . ARG A 1 678 ? 127.560 107.595 133.252 1.00 54.05  ? 704 ARG A CD  1 
ATOM   5294 N NE  . ARG A 1 678 ? 126.922 108.001 134.497 1.00 50.14  ? 704 ARG A NE  1 
ATOM   5295 C CZ  . ARG A 1 678 ? 126.772 107.212 135.551 1.00 57.77  ? 704 ARG A CZ  1 
ATOM   5296 N NH1 . ARG A 1 678 ? 127.177 105.953 135.535 1.00 60.73  ? 704 ARG A NH1 1 
ATOM   5297 N NH2 . ARG A 1 678 ? 126.198 107.697 136.648 1.00 58.93  ? 704 ARG A NH2 1 
ATOM   5298 N N   . ASN A 1 679 ? 125.393 111.714 133.388 1.00 55.14  ? 705 ASN A N   1 
ATOM   5299 C CA  . ASN A 1 679 ? 123.964 111.807 133.668 1.00 52.08  ? 705 ASN A CA  1 
ATOM   5300 C C   . ASN A 1 679 ? 123.259 112.675 132.635 1.00 49.85  ? 705 ASN A C   1 
ATOM   5301 O O   . ASN A 1 679 ? 122.142 112.363 132.207 1.00 53.01  ? 705 ASN A O   1 
ATOM   5302 C CB  . ASN A 1 679 ? 123.734 112.359 135.075 1.00 50.44  ? 705 ASN A CB  1 
ATOM   5303 C CG  . ASN A 1 679 ? 124.097 111.366 136.158 1.00 58.86  ? 705 ASN A CG  1 
ATOM   5304 O OD1 . ASN A 1 679 ? 124.845 110.417 135.922 1.00 65.85  ? 705 ASN A OD1 1 
ATOM   5305 N ND2 . ASN A 1 679 ? 123.568 111.580 137.356 1.00 57.48  ? 705 ASN A ND2 1 
ATOM   5306 N N   . LEU A 1 680 ? 123.898 113.771 132.222 1.00 46.82  ? 706 LEU A N   1 
ATOM   5307 C CA  . LEU A 1 680 ? 123.268 114.664 131.252 1.00 41.11  ? 706 LEU A CA  1 
ATOM   5308 C C   . LEU A 1 680 ? 123.153 114.016 129.878 1.00 43.07  ? 706 LEU A C   1 
ATOM   5309 O O   . LEU A 1 680 ? 122.116 114.138 129.216 1.00 47.10  ? 706 LEU A O   1 
ATOM   5310 C CB  . LEU A 1 680 ? 124.045 115.975 131.154 1.00 42.46  ? 706 LEU A CB  1 
ATOM   5311 C CG  . LEU A 1 680 ? 123.618 117.081 132.117 1.00 42.24  ? 706 LEU A CG  1 
ATOM   5312 C CD1 . LEU A 1 680 ? 124.419 118.345 131.870 1.00 44.90  ? 706 LEU A CD1 1 
ATOM   5313 C CD2 . LEU A 1 680 ? 122.130 117.354 131.985 1.00 41.98  ? 706 LEU A CD2 1 
ATOM   5314 N N   . ILE A 1 681 ? 124.200 113.325 129.428 1.00 48.51  ? 707 ILE A N   1 
ATOM   5315 C CA  . ILE A 1 681 ? 124.247 112.856 128.046 1.00 45.86  ? 707 ILE A CA  1 
ATOM   5316 C C   . ILE A 1 681 ? 123.517 111.528 127.887 1.00 49.17  ? 707 ILE A C   1 
ATOM   5317 O O   . ILE A 1 681 ? 122.557 111.427 127.115 1.00 49.05  ? 707 ILE A O   1 
ATOM   5318 C CB  . ILE A 1 681 ? 125.700 112.739 127.552 1.00 42.83  ? 707 ILE A CB  1 
ATOM   5319 C CG1 . ILE A 1 681 ? 126.397 114.098 127.625 1.00 45.31  ? 707 ILE A CG1 1 
ATOM   5320 C CG2 . ILE A 1 681 ? 125.734 112.211 126.130 1.00 43.11  ? 707 ILE A CG2 1 
ATOM   5321 C CD1 . ILE A 1 681 ? 127.825 114.080 127.135 1.00 47.72  ? 707 ILE A CD1 1 
ATOM   5322 N N   . LEU A 1 682 ? 123.956 110.503 128.613 1.00 48.56  ? 708 LEU A N   1 
ATOM   5323 C CA  . LEU A 1 682 ? 123.458 109.147 128.423 1.00 44.62  ? 708 LEU A CA  1 
ATOM   5324 C C   . LEU A 1 682 ? 122.350 108.766 129.399 1.00 46.13  ? 708 LEU A C   1 
ATOM   5325 O O   . LEU A 1 682 ? 121.950 107.599 129.431 1.00 54.33  ? 708 LEU A O   1 
ATOM   5326 C CB  . LEU A 1 682 ? 124.603 108.137 128.537 1.00 48.55  ? 708 LEU A CB  1 
ATOM   5327 C CG  . LEU A 1 682 ? 125.683 108.136 127.453 1.00 52.61  ? 708 LEU A CG  1 
ATOM   5328 C CD1 . LEU A 1 682 ? 126.796 109.121 127.779 1.00 52.75  ? 708 LEU A CD1 1 
ATOM   5329 C CD2 . LEU A 1 682 ? 126.244 106.737 127.259 1.00 50.84  ? 708 LEU A CD2 1 
ATOM   5330 N N   . GLY A 1 683 ? 121.849 109.707 130.191 1.00 45.38  ? 709 GLY A N   1 
ATOM   5331 C CA  . GLY A 1 683 ? 120.811 109.413 131.154 1.00 49.59  ? 709 GLY A CA  1 
ATOM   5332 C C   . GLY A 1 683 ? 121.360 108.951 132.492 1.00 54.84  ? 709 GLY A C   1 
ATOM   5333 O O   . GLY A 1 683 ? 122.558 108.729 132.676 1.00 60.95  ? 709 GLY A O   1 
ATOM   5334 N N   . ARG A 1 684 ? 120.444 108.802 133.451 1.00 53.98  ? 710 ARG A N   1 
ATOM   5335 C CA  . ARG A 1 684 ? 120.819 108.520 134.829 1.00 55.24  ? 710 ARG A CA  1 
ATOM   5336 C C   . ARG A 1 684 ? 120.636 107.043 135.135 1.00 58.04  ? 710 ARG A C   1 
ATOM   5337 O O   . ARG A 1 684 ? 119.553 106.495 134.878 1.00 63.43  ? 710 ARG A O   1 
ATOM   5338 C CB  . ARG A 1 684 ? 119.987 109.364 135.787 1.00 54.61  ? 710 ARG A CB  1 
ATOM   5339 C CG  . ARG A 1 684 ? 120.310 109.135 137.247 1.00 57.42  ? 710 ARG A CG  1 
ATOM   5340 C CD  . ARG A 1 684 ? 119.544 110.093 138.139 1.00 59.56  ? 710 ARG A CD  1 
ATOM   5341 N NE  . ARG A 1 684 ? 119.980 111.472 137.960 1.00 58.82  ? 710 ARG A NE  1 
ATOM   5342 C CZ  . ARG A 1 684 ? 119.523 112.498 138.664 1.00 59.78  ? 710 ARG A CZ  1 
ATOM   5343 N NH1 . ARG A 1 684 ? 118.608 112.337 139.605 1.00 60.56  ? 710 ARG A NH1 1 
ATOM   5344 N NH2 . ARG A 1 684 ? 119.997 113.716 138.419 1.00 59.67  ? 710 ARG A NH2 1 
ATOM   5345 N N   . PRO A 1 685 ? 121.651 106.363 135.673 1.00 56.33  ? 711 PRO A N   1 
ATOM   5346 C CA  . PRO A 1 685 ? 121.509 104.939 136.006 1.00 57.49  ? 711 PRO A CA  1 
ATOM   5347 C C   . PRO A 1 685 ? 120.694 104.692 137.265 1.00 62.62  ? 711 PRO A C   1 
ATOM   5348 O O   . PRO A 1 685 ? 120.138 105.623 137.856 1.00 65.29  ? 711 PRO A O   1 
ATOM   5349 C CB  . PRO A 1 685 ? 122.961 104.474 136.194 1.00 58.45  ? 711 PRO A CB  1 
ATOM   5350 C CG  . PRO A 1 685 ? 123.807 105.559 135.609 1.00 59.14  ? 711 PRO A CG  1 
ATOM   5351 C CD  . PRO A 1 685 ? 123.040 106.818 135.818 1.00 58.82  ? 711 PRO A CD  1 
ATOM   5352 N N   . SER A 1 686 ? 120.620 103.428 137.676 1.00 72.74  ? 712 SER A N   1 
ATOM   5353 C CA  . SER A 1 686 ? 119.919 103.055 138.894 1.00 73.34  ? 712 SER A CA  1 
ATOM   5354 C C   . SER A 1 686 ? 120.635 103.612 140.122 1.00 69.82  ? 712 SER A C   1 
ATOM   5355 O O   . SER A 1 686 ? 121.795 104.029 140.066 1.00 74.32  ? 712 SER A O   1 
ATOM   5356 C CB  . SER A 1 686 ? 119.799 101.535 139.002 1.00 73.56  ? 712 SER A CB  1 
ATOM   5357 O OG  . SER A 1 686 ? 119.079 101.000 137.905 1.00 73.81  ? 712 SER A OG  1 
ATOM   5358 N N   . LEU A 1 687 ? 119.918 103.614 141.249 1.00 71.37  ? 713 LEU A N   1 
ATOM   5359 C CA  . LEU A 1 687 ? 120.432 104.250 142.458 1.00 71.81  ? 713 LEU A CA  1 
ATOM   5360 C C   . LEU A 1 687 ? 121.659 103.534 143.007 1.00 75.13  ? 713 LEU A C   1 
ATOM   5361 O O   . LEU A 1 687 ? 122.523 104.176 143.614 1.00 81.22  ? 713 LEU A O   1 
ATOM   5362 C CB  . LEU A 1 687 ? 119.342 104.317 143.528 1.00 72.36  ? 713 LEU A CB  1 
ATOM   5363 C CG  . LEU A 1 687 ? 118.294 105.428 143.410 1.00 77.67  ? 713 LEU A CG  1 
ATOM   5364 C CD1 . LEU A 1 687 ? 118.966 106.775 143.198 1.00 77.43  ? 713 LEU A CD1 1 
ATOM   5365 C CD2 . LEU A 1 687 ? 117.281 105.144 142.308 1.00 77.83  ? 713 LEU A CD2 1 
ATOM   5366 N N   . GLU A 1 688 ? 121.753 102.216 142.818 1.00 78.27  ? 714 GLU A N   1 
ATOM   5367 C CA  . GLU A 1 688 ? 122.910 101.484 143.324 1.00 82.88  ? 714 GLU A CA  1 
ATOM   5368 C C   . GLU A 1 688 ? 124.193 101.930 142.631 1.00 85.57  ? 714 GLU A C   1 
ATOM   5369 O O   . GLU A 1 688 ? 125.214 102.166 143.289 1.00 84.26  ? 714 GLU A O   1 
ATOM   5370 C CB  . GLU A 1 688 ? 122.690 99.980  143.151 1.00 82.18  ? 714 GLU A CB  1 
ATOM   5371 C CG  . GLU A 1 688 ? 123.798 99.104  143.723 1.00 84.56  ? 714 GLU A CG  1 
ATOM   5372 C CD  . GLU A 1 688 ? 124.879 98.783  142.709 1.00 87.58  ? 714 GLU A CD  1 
ATOM   5373 O OE1 . GLU A 1 688 ? 124.685 99.090  141.513 1.00 86.97  ? 714 GLU A OE1 1 
ATOM   5374 O OE2 . GLU A 1 688 ? 125.922 98.222  143.106 1.00 88.00  ? 714 GLU A OE2 1 
ATOM   5375 N N   . GLN A 1 689 ? 124.154 102.068 141.304 1.00 79.26  ? 715 GLN A N   1 
ATOM   5376 C CA  . GLN A 1 689 ? 125.334 102.514 140.573 1.00 77.05  ? 715 GLN A CA  1 
ATOM   5377 C C   . GLN A 1 689 ? 125.688 103.953 140.925 1.00 77.49  ? 715 GLN A C   1 
ATOM   5378 O O   . GLN A 1 689 ? 126.871 104.297 141.034 1.00 80.31  ? 715 GLN A O   1 
ATOM   5379 C CB  . GLN A 1 689 ? 125.108 102.363 139.069 1.00 77.06  ? 715 GLN A CB  1 
ATOM   5380 C CG  . GLN A 1 689 ? 126.335 102.664 138.222 1.00 78.89  ? 715 GLN A CG  1 
ATOM   5381 C CD  . GLN A 1 689 ? 126.117 102.366 136.752 1.00 79.75  ? 715 GLN A CD  1 
ATOM   5382 O OE1 . GLN A 1 689 ? 125.048 101.904 136.352 1.00 80.75  ? 715 GLN A OE1 1 
ATOM   5383 N NE2 . GLN A 1 689 ? 127.132 102.628 135.937 1.00 75.80  ? 715 GLN A NE2 1 
ATOM   5384 N N   . LEU A 1 690 ? 124.679 104.810 141.101 1.00 66.51  ? 716 LEU A N   1 
ATOM   5385 C CA  . LEU A 1 690 ? 124.946 106.187 141.503 1.00 61.40  ? 716 LEU A CA  1 
ATOM   5386 C C   . LEU A 1 690 ? 125.610 106.242 142.871 1.00 67.94  ? 716 LEU A C   1 
ATOM   5387 O O   . LEU A 1 690 ? 126.566 107.001 143.074 1.00 77.41  ? 716 LEU A O   1 
ATOM   5388 C CB  . LEU A 1 690 ? 123.652 106.997 141.512 1.00 62.17  ? 716 LEU A CB  1 
ATOM   5389 C CG  . LEU A 1 690 ? 123.220 107.633 140.193 1.00 69.07  ? 716 LEU A CG  1 
ATOM   5390 C CD1 . LEU A 1 690 ? 121.924 108.398 140.389 1.00 71.03  ? 716 LEU A CD1 1 
ATOM   5391 C CD2 . LEU A 1 690 ? 124.309 108.549 139.666 1.00 65.70  ? 716 LEU A CD2 1 
ATOM   5392 N N   . ALA A 1 691 ? 125.118 105.447 143.823 1.00 62.45  ? 717 ALA A N   1 
ATOM   5393 C CA  . ALA A 1 691 ? 125.736 105.412 145.143 1.00 61.73  ? 717 ALA A CA  1 
ATOM   5394 C C   . ALA A 1 691 ? 127.164 104.891 145.065 1.00 65.97  ? 717 ALA A C   1 
ATOM   5395 O O   . ALA A 1 691 ? 128.059 105.414 145.740 1.00 70.85  ? 717 ALA A O   1 
ATOM   5396 C CB  . ALA A 1 691 ? 124.900 104.557 146.094 1.00 63.40  ? 717 ALA A CB  1 
ATOM   5397 N N   . GLN A 1 692 ? 127.399 103.871 144.235 1.00 64.65  ? 718 GLN A N   1 
ATOM   5398 C CA  . GLN A 1 692 ? 128.751 103.344 144.080 1.00 68.49  ? 718 GLN A CA  1 
ATOM   5399 C C   . GLN A 1 692 ? 129.692 104.396 143.504 1.00 71.35  ? 718 GLN A C   1 
ATOM   5400 O O   . GLN A 1 692 ? 130.826 104.551 143.973 1.00 76.12  ? 718 GLN A O   1 
ATOM   5401 C CB  . GLN A 1 692 ? 128.729 102.100 143.193 1.00 70.14  ? 718 GLN A CB  1 
ATOM   5402 C CG  . GLN A 1 692 ? 130.101 101.506 142.916 1.00 73.32  ? 718 GLN A CG  1 
ATOM   5403 C CD  . GLN A 1 692 ? 130.760 100.942 144.161 1.00 75.50  ? 718 GLN A CD  1 
ATOM   5404 O OE1 . GLN A 1 692 ? 130.087 100.590 145.130 1.00 77.79  ? 718 GLN A OE1 1 
ATOM   5405 N NE2 . GLN A 1 692 ? 132.085 100.854 144.139 1.00 71.05  ? 718 GLN A NE2 1 
ATOM   5406 N N   . GLU A 1 693 ? 129.233 105.139 142.496 1.00 62.48  ? 719 GLU A N   1 
ATOM   5407 C CA  . GLU A 1 693 ? 130.082 106.154 141.882 1.00 55.75  ? 719 GLU A CA  1 
ATOM   5408 C C   . GLU A 1 693 ? 130.341 107.315 142.834 1.00 62.58  ? 719 GLU A C   1 
ATOM   5409 O O   . GLU A 1 693 ? 131.448 107.865 142.860 1.00 71.72  ? 719 GLU A O   1 
ATOM   5410 C CB  . GLU A 1 693 ? 129.451 106.652 140.585 1.00 62.86  ? 719 GLU A CB  1 
ATOM   5411 C CG  . GLU A 1 693 ? 129.380 105.602 139.494 1.00 67.83  ? 719 GLU A CG  1 
ATOM   5412 C CD  . GLU A 1 693 ? 128.734 106.123 138.229 1.00 72.39  ? 719 GLU A CD  1 
ATOM   5413 O OE1 . GLU A 1 693 ? 128.356 107.313 138.200 1.00 72.30  ? 719 GLU A OE1 1 
ATOM   5414 O OE2 . GLU A 1 693 ? 128.605 105.342 137.263 1.00 73.12  ? 719 GLU A OE2 1 
ATOM   5415 N N   . VAL A 1 694 ? 129.337 107.703 143.623 1.00 56.54  ? 720 VAL A N   1 
ATOM   5416 C CA  . VAL A 1 694 ? 129.542 108.774 144.593 1.00 53.58  ? 720 VAL A CA  1 
ATOM   5417 C C   . VAL A 1 694 ? 130.511 108.328 145.681 1.00 55.28  ? 720 VAL A C   1 
ATOM   5418 O O   . VAL A 1 694 ? 131.349 109.112 146.144 1.00 62.59  ? 720 VAL A O   1 
ATOM   5419 C CB  . VAL A 1 694 ? 128.195 109.234 145.178 1.00 58.23  ? 720 VAL A CB  1 
ATOM   5420 C CG1 . VAL A 1 694 ? 128.414 110.189 146.340 1.00 59.77  ? 720 VAL A CG1 1 
ATOM   5421 C CG2 . VAL A 1 694 ? 127.357 109.903 144.102 1.00 61.45  ? 720 VAL A CG2 1 
ATOM   5422 N N   . THR A 1 695 ? 130.426 107.063 146.098 1.00 57.74  ? 721 THR A N   1 
ATOM   5423 C CA  . THR A 1 695 ? 131.381 106.542 147.071 1.00 60.78  ? 721 THR A CA  1 
ATOM   5424 C C   . THR A 1 695 ? 132.791 106.513 146.495 1.00 61.10  ? 721 THR A C   1 
ATOM   5425 O O   . THR A 1 695 ? 133.760 106.836 147.192 1.00 69.18  ? 721 THR A O   1 
ATOM   5426 C CB  . THR A 1 695 ? 130.958 105.146 147.527 1.00 63.18  ? 721 THR A CB  1 
ATOM   5427 O OG1 . THR A 1 695 ? 129.664 105.214 148.140 1.00 65.37  ? 721 THR A OG1 1 
ATOM   5428 C CG2 . THR A 1 695 ? 131.955 104.580 148.525 1.00 62.24  ? 721 THR A CG2 1 
ATOM   5429 N N   . TYR A 1 696 ? 132.925 106.139 145.221 1.00 57.74  ? 722 TYR A N   1 
ATOM   5430 C CA  . TYR A 1 696 ? 134.244 106.099 144.599 1.00 57.49  ? 722 TYR A CA  1 
ATOM   5431 C C   . TYR A 1 696 ? 134.829 107.494 144.422 1.00 61.85  ? 722 TYR A C   1 
ATOM   5432 O O   . TYR A 1 696 ? 136.046 107.673 144.547 1.00 65.31  ? 722 TYR A O   1 
ATOM   5433 C CB  . TYR A 1 696 ? 134.170 105.382 143.252 1.00 59.98  ? 722 TYR A CB  1 
ATOM   5434 C CG  . TYR A 1 696 ? 135.478 105.359 142.495 1.00 58.79  ? 722 TYR A CG  1 
ATOM   5435 C CD1 . TYR A 1 696 ? 136.446 104.407 142.774 1.00 57.38  ? 722 TYR A CD1 1 
ATOM   5436 C CD2 . TYR A 1 696 ? 135.742 106.287 141.496 1.00 62.48  ? 722 TYR A CD2 1 
ATOM   5437 C CE1 . TYR A 1 696 ? 137.642 104.380 142.085 1.00 59.98  ? 722 TYR A CE1 1 
ATOM   5438 C CE2 . TYR A 1 696 ? 136.935 106.269 140.802 1.00 62.95  ? 722 TYR A CE2 1 
ATOM   5439 C CZ  . TYR A 1 696 ? 137.881 105.314 141.100 1.00 62.33  ? 722 TYR A CZ  1 
ATOM   5440 O OH  . TYR A 1 696 ? 139.071 105.291 140.411 1.00 64.45  ? 722 TYR A OH  1 
ATOM   5441 N N   . ALA A 1 697 ? 133.988 108.488 144.129 1.00 59.78  ? 723 ALA A N   1 
ATOM   5442 C CA  . ALA A 1 697 ? 134.495 109.839 143.918 1.00 53.91  ? 723 ALA A CA  1 
ATOM   5443 C C   . ALA A 1 697 ? 134.976 110.475 145.215 1.00 56.44  ? 723 ALA A C   1 
ATOM   5444 O O   . ALA A 1 697 ? 135.827 111.371 145.184 1.00 62.49  ? 723 ALA A O   1 
ATOM   5445 C CB  . ALA A 1 697 ? 133.418 110.708 143.272 1.00 55.05  ? 723 ALA A CB  1 
ATOM   5446 N N   . ASN A 1 698 ? 134.453 110.033 146.355 1.00 57.01  ? 724 ASN A N   1 
ATOM   5447 C CA  . ASN A 1 698 ? 134.820 110.588 147.649 1.00 58.18  ? 724 ASN A CA  1 
ATOM   5448 C C   . ASN A 1 698 ? 135.979 109.853 148.310 1.00 61.78  ? 724 ASN A C   1 
ATOM   5449 O O   . ASN A 1 698 ? 136.346 110.196 149.438 1.00 64.42  ? 724 ASN A O   1 
ATOM   5450 C CB  . ASN A 1 698 ? 133.608 110.583 148.585 1.00 62.43  ? 724 ASN A CB  1 
ATOM   5451 C CG  . ASN A 1 698 ? 132.445 111.386 148.036 1.00 70.76  ? 724 ASN A CG  1 
ATOM   5452 O OD1 . ASN A 1 698 ? 132.415 111.726 146.854 1.00 71.85  ? 724 ASN A OD1 1 
ATOM   5453 N ND2 . ASN A 1 698 ? 131.479 111.692 148.894 1.00 66.35  ? 724 ASN A ND2 1 
ATOM   5454 N N   . LEU A 1 699 ? 136.559 108.858 147.645 1.00 69.49  ? 725 LEU A N   1 
ATOM   5455 C CA  . LEU A 1 699 ? 137.624 108.071 148.250 1.00 69.52  ? 725 LEU A CA  1 
ATOM   5456 C C   . LEU A 1 699 ? 138.919 108.872 148.329 1.00 73.65  ? 725 LEU A C   1 
ATOM   5457 O O   . LEU A 1 699 ? 139.263 109.620 147.411 1.00 74.87  ? 725 LEU A O   1 
ATOM   5458 C CB  . LEU A 1 699 ? 137.850 106.788 147.451 1.00 68.39  ? 725 LEU A CB  1 
ATOM   5459 C CG  . LEU A 1 699 ? 138.843 105.779 148.029 1.00 72.56  ? 725 LEU A CG  1 
ATOM   5460 C CD1 . LEU A 1 699 ? 138.380 105.291 149.392 1.00 71.87  ? 725 LEU A CD1 1 
ATOM   5461 C CD2 . LEU A 1 699 ? 139.037 104.612 147.074 1.00 72.85  ? 725 LEU A CD2 1 
ATOM   5462 N N   . ARG A 1 700 ? 139.636 108.710 149.440 1.00 87.46  ? 726 ARG A N   1 
ATOM   5463 C CA  . ARG A 1 700 ? 140.934 109.346 149.592 1.00 87.95  ? 726 ARG A CA  1 
ATOM   5464 C C   . ARG A 1 700 ? 141.942 108.734 148.618 1.00 89.46  ? 726 ARG A C   1 
ATOM   5465 O O   . ARG A 1 700 ? 141.846 107.553 148.274 1.00 91.26  ? 726 ARG A O   1 
ATOM   5466 C CB  . ARG A 1 700 ? 141.439 109.196 151.023 1.00 87.15  ? 726 ARG A CB  1 
ATOM   5467 C CG  . ARG A 1 700 ? 140.664 110.009 152.047 1.00 88.07  ? 726 ARG A CG  1 
ATOM   5468 C CD  . ARG A 1 700 ? 140.804 111.499 151.785 1.00 89.38  ? 726 ARG A CD  1 
ATOM   5469 N NE  . ARG A 1 700 ? 140.258 112.299 152.875 1.00 92.70  ? 726 ARG A NE  1 
ATOM   5470 C CZ  . ARG A 1 700 ? 139.003 112.720 152.941 1.00 91.85  ? 726 ARG A CZ  1 
ATOM   5471 N NH1 . ARG A 1 700 ? 138.126 112.433 151.992 1.00 89.71  ? 726 ARG A NH1 1 
ATOM   5472 N NH2 . ARG A 1 700 ? 138.617 113.448 153.985 1.00 89.64  ? 726 ARG A NH2 1 
ATOM   5473 N N   . PRO A 1 701 ? 142.913 109.524 148.149 1.00 85.62  ? 727 PRO A N   1 
ATOM   5474 C CA  . PRO A 1 701 ? 143.873 108.982 147.169 1.00 85.85  ? 727 PRO A CA  1 
ATOM   5475 C C   . PRO A 1 701 ? 144.711 107.835 147.707 1.00 88.87  ? 727 PRO A C   1 
ATOM   5476 O O   . PRO A 1 701 ? 144.713 106.745 147.120 1.00 86.93  ? 727 PRO A O   1 
ATOM   5477 C CB  . PRO A 1 701 ? 144.734 110.205 146.819 1.00 83.12  ? 727 PRO A CB  1 
ATOM   5478 C CG  . PRO A 1 701 ? 143.911 111.386 147.202 1.00 82.80  ? 727 PRO A CG  1 
ATOM   5479 C CD  . PRO A 1 701 ? 143.131 110.957 148.402 1.00 83.44  ? 727 PRO A CD  1 
ATOM   5480 N N   . PHE A 1 702 ? 145.407 108.047 148.823 1.00 104.16 ? 728 PHE A N   1 
ATOM   5481 C CA  . PHE A 1 702 ? 146.333 107.064 149.388 1.00 104.86 ? 728 PHE A CA  1 
ATOM   5482 C C   . PHE A 1 702 ? 147.283 106.487 148.340 1.00 103.04 ? 728 PHE A C   1 
ATOM   5483 O O   . PHE A 1 702 ? 147.829 107.217 147.513 1.00 100.87 ? 728 PHE A O   1 
ATOM   5484 C CB  . PHE A 1 702 ? 145.563 105.933 150.074 1.00 102.51 ? 728 PHE A CB  1 
ATOM   5485 C CG  . PHE A 1 702 ? 145.157 106.248 151.485 1.00 101.91 ? 728 PHE A CG  1 
ATOM   5486 C CD1 . PHE A 1 702 ? 146.057 106.098 152.526 1.00 100.77 ? 728 PHE A CD1 1 
ATOM   5487 C CD2 . PHE A 1 702 ? 143.878 106.693 151.771 1.00 102.44 ? 728 PHE A CD2 1 
ATOM   5488 C CE1 . PHE A 1 702 ? 145.690 106.387 153.827 1.00 101.72 ? 728 PHE A CE1 1 
ATOM   5489 C CE2 . PHE A 1 702 ? 143.504 106.983 153.070 1.00 103.53 ? 728 PHE A CE2 1 
ATOM   5490 C CZ  . PHE A 1 702 ? 144.411 106.830 154.099 1.00 102.69 ? 728 PHE A CZ  1 
ATOM   5491 N N   . GLU B 2 2   ? 113.990 121.066 158.021 1.00 93.73  ? 25  GLU P N   1 
ATOM   5492 C CA  . GLU B 2 2   ? 115.096 120.599 158.847 1.00 93.57  ? 25  GLU P CA  1 
ATOM   5493 C C   . GLU B 2 2   ? 114.645 120.370 160.286 1.00 94.10  ? 25  GLU P C   1 
ATOM   5494 O O   . GLU B 2 2   ? 115.242 120.905 161.222 1.00 94.55  ? 25  GLU P O   1 
ATOM   5495 C CB  . GLU B 2 2   ? 116.253 121.599 158.809 1.00 93.41  ? 25  GLU P CB  1 
ATOM   5496 C CG  . GLU B 2 2   ? 116.808 121.853 157.418 1.00 94.19  ? 25  GLU P CG  1 
ATOM   5497 C CD  . GLU B 2 2   ? 117.952 122.847 157.421 1.00 94.46  ? 25  GLU P CD  1 
ATOM   5498 O OE1 . GLU B 2 2   ? 118.340 123.305 158.516 1.00 93.88  ? 25  GLU P OE1 1 
ATOM   5499 O OE2 . GLU B 2 2   ? 118.462 123.172 156.328 1.00 93.76  ? 25  GLU P OE2 1 
ATOM   5500 N N   . THR B 2 3   ? 113.581 119.578 160.444 1.00 99.31  ? 26  THR P N   1 
ATOM   5501 C CA  . THR B 2 3   ? 113.013 119.228 161.744 1.00 98.84  ? 26  THR P CA  1 
ATOM   5502 C C   . THR B 2 3   ? 112.581 120.465 162.524 1.00 98.63  ? 26  THR P C   1 
ATOM   5503 O O   . THR B 2 3   ? 112.566 121.577 161.985 1.00 97.99  ? 26  THR P O   1 
ATOM   5504 C CB  . THR B 2 3   ? 114.003 118.401 162.574 1.00 97.68  ? 26  THR P CB  1 
ATOM   5505 O OG1 . THR B 2 3   ? 115.111 119.221 162.969 1.00 98.47  ? 26  THR P OG1 1 
ATOM   5506 C CG2 . THR B 2 3   ? 114.516 117.214 161.770 1.00 96.97  ? 26  THR P CG2 1 
ATOM   5507 N N   . ASP B 2 4   ? 112.213 120.279 163.792 1.00 92.87  ? 27  ASP P N   1 
ATOM   5508 C CA  . ASP B 2 4   ? 111.809 121.376 164.661 1.00 91.48  ? 27  ASP P CA  1 
ATOM   5509 C C   . ASP B 2 4   ? 112.824 121.639 165.768 1.00 91.16  ? 27  ASP P C   1 
ATOM   5510 O O   . ASP B 2 4   ? 112.515 122.342 166.736 1.00 90.92  ? 27  ASP P O   1 
ATOM   5511 C CB  . ASP B 2 4   ? 110.430 121.100 165.260 1.00 91.91  ? 27  ASP P CB  1 
ATOM   5512 C CG  . ASP B 2 4   ? 109.330 121.097 164.216 1.00 92.88  ? 27  ASP P CG  1 
ATOM   5513 O OD1 . ASP B 2 4   ? 109.637 121.319 163.026 1.00 91.84  ? 27  ASP P OD1 1 
ATOM   5514 O OD2 . ASP B 2 4   ? 108.158 120.876 164.586 1.00 93.20  ? 27  ASP P OD2 1 
ATOM   5515 N N   . GLN B 2 5   ? 114.033 121.087 165.645 1.00 88.89  ? 28  GLN P N   1 
ATOM   5516 C CA  . GLN B 2 5   ? 115.090 121.315 166.618 1.00 88.49  ? 28  GLN P CA  1 
ATOM   5517 C C   . GLN B 2 5   ? 116.238 122.154 166.080 1.00 87.75  ? 28  GLN P C   1 
ATOM   5518 O O   . GLN B 2 5   ? 117.021 122.681 166.876 1.00 88.84  ? 28  GLN P O   1 
ATOM   5519 C CB  . GLN B 2 5   ? 115.648 119.977 167.126 1.00 88.25  ? 28  GLN P CB  1 
ATOM   5520 C CG  . GLN B 2 5   ? 114.617 119.104 167.825 1.00 89.41  ? 28  GLN P CG  1 
ATOM   5521 C CD  . GLN B 2 5   ? 115.206 117.806 168.341 1.00 89.50  ? 28  GLN P CD  1 
ATOM   5522 O OE1 . GLN B 2 5   ? 116.400 117.548 168.191 1.00 89.30  ? 28  GLN P OE1 1 
ATOM   5523 N NE2 . GLN B 2 5   ? 114.367 116.979 168.954 1.00 88.27  ? 28  GLN P NE2 1 
ATOM   5524 N N   . GLU B 2 6   ? 116.358 122.287 164.760 1.00 71.72  ? 29  GLU P N   1 
ATOM   5525 C CA  . GLU B 2 6   ? 117.353 123.152 164.148 1.00 68.88  ? 29  GLU P CA  1 
ATOM   5526 C C   . GLU B 2 6   ? 116.774 124.479 163.680 1.00 68.76  ? 29  GLU P C   1 
ATOM   5527 O O   . GLU B 2 6   ? 117.540 125.369 163.297 1.00 71.83  ? 29  GLU P O   1 
ATOM   5528 C CB  . GLU B 2 6   ? 118.011 122.442 162.958 1.00 71.01  ? 29  GLU P CB  1 
ATOM   5529 C CG  . GLU B 2 6   ? 118.543 121.056 163.276 1.00 74.19  ? 29  GLU P CG  1 
ATOM   5530 C CD  . GLU B 2 6   ? 119.030 120.323 162.040 1.00 75.81  ? 29  GLU P CD  1 
ATOM   5531 O OE1 . GLU B 2 6   ? 119.068 120.943 160.956 1.00 74.40  ? 29  GLU P OE1 1 
ATOM   5532 O OE2 . GLU B 2 6   ? 119.371 119.127 162.153 1.00 74.85  ? 29  GLU P OE2 1 
ATOM   5533 N N   . VAL B 2 7   ? 115.452 124.632 163.704 1.00 48.76  ? 30  VAL P N   1 
ATOM   5534 C CA  . VAL B 2 7   ? 114.798 125.828 163.190 1.00 43.52  ? 30  VAL P CA  1 
ATOM   5535 C C   . VAL B 2 7   ? 114.313 126.697 164.343 1.00 53.04  ? 30  VAL P C   1 
ATOM   5536 O O   . VAL B 2 7   ? 114.311 127.929 164.248 1.00 58.53  ? 30  VAL P O   1 
ATOM   5537 C CB  . VAL B 2 7   ? 113.634 125.456 162.254 1.00 45.00  ? 30  VAL P CB  1 
ATOM   5538 C CG1 . VAL B 2 7   ? 113.088 126.694 161.563 1.00 50.22  ? 30  VAL P CG1 1 
ATOM   5539 C CG2 . VAL B 2 7   ? 114.087 124.427 161.235 1.00 52.28  ? 30  VAL P CG2 1 
ATOM   5540 N N   . PHE B 2 8   ? 113.910 126.067 165.443 1.00 42.90  ? 31  PHE P N   1 
ATOM   5541 C CA  . PHE B 2 8   ? 113.330 126.770 166.576 1.00 32.16  ? 31  PHE P CA  1 
ATOM   5542 C C   . PHE B 2 8   ? 114.210 126.617 167.809 1.00 35.86  ? 31  PHE P C   1 
ATOM   5543 O O   . PHE B 2 8   ? 114.853 125.584 168.012 1.00 41.02  ? 31  PHE P O   1 
ATOM   5544 C CB  . PHE B 2 8   ? 111.922 126.256 166.889 1.00 32.64  ? 31  PHE P CB  1 
ATOM   5545 C CG  . PHE B 2 8   ? 110.937 126.466 165.778 1.00 32.79  ? 31  PHE P CG  1 
ATOM   5546 C CD1 . PHE B 2 8   ? 110.303 127.683 165.619 1.00 33.02  ? 31  PHE P CD1 1 
ATOM   5547 C CD2 . PHE B 2 8   ? 110.632 125.440 164.902 1.00 39.83  ? 31  PHE P CD2 1 
ATOM   5548 C CE1 . PHE B 2 8   ? 109.393 127.877 164.603 1.00 35.91  ? 31  PHE P CE1 1 
ATOM   5549 C CE2 . PHE B 2 8   ? 109.720 125.630 163.883 1.00 37.57  ? 31  PHE P CE2 1 
ATOM   5550 C CZ  . PHE B 2 8   ? 109.101 126.851 163.735 1.00 35.00  ? 31  PHE P CZ  1 
ATOM   5551 N N   . LEU B 2 9   ? 114.225 127.662 168.635 1.00 34.31  ? 32  LEU P N   1 
ATOM   5552 C CA  . LEU B 2 9   ? 114.960 127.673 169.890 1.00 30.96  ? 32  LEU P CA  1 
ATOM   5553 C C   . LEU B 2 9   ? 114.024 128.061 171.024 1.00 31.85  ? 32  LEU P C   1 
ATOM   5554 O O   . LEU B 2 9   ? 113.055 128.799 170.827 1.00 37.95  ? 32  LEU P O   1 
ATOM   5555 C CB  . LEU B 2 9   ? 116.143 128.646 169.852 1.00 26.92  ? 32  LEU P CB  1 
ATOM   5556 C CG  . LEU B 2 9   ? 117.337 128.280 168.975 1.00 34.13  ? 32  LEU P CG  1 
ATOM   5557 C CD1 . LEU B 2 9   ? 118.417 129.337 169.102 1.00 32.87  ? 32  LEU P CD1 1 
ATOM   5558 C CD2 . LEU B 2 9   ? 117.878 126.912 169.353 1.00 35.79  ? 32  LEU P CD2 1 
ATOM   5559 N N   . GLY B 2 10  ? 114.324 127.556 172.217 1.00 28.98  ? 33  GLY P N   1 
ATOM   5560 C CA  . GLY B 2 10  ? 113.548 127.872 173.390 1.00 30.41  ? 33  GLY P CA  1 
ATOM   5561 C C   . GLY B 2 10  ? 113.803 129.283 173.874 1.00 36.78  ? 33  GLY P C   1 
ATOM   5562 O O   . GLY B 2 10  ? 114.823 129.901 173.552 1.00 42.25  ? 33  GLY P O   1 
ATOM   5563 N N   . PRO B 2 11  ? 112.867 129.826 174.646 1.00 30.23  ? 34  PRO P N   1 
ATOM   5564 C CA  . PRO B 2 11  ? 113.036 131.176 175.199 1.00 23.93  ? 34  PRO P CA  1 
ATOM   5565 C C   . PRO B 2 11  ? 114.298 131.324 176.036 1.00 23.19  ? 34  PRO P C   1 
ATOM   5566 O O   . PRO B 2 11  ? 114.959 132.370 175.955 1.00 30.54  ? 34  PRO P O   1 
ATOM   5567 C CB  . PRO B 2 11  ? 111.770 131.364 176.047 1.00 26.78  ? 34  PRO P CB  1 
ATOM   5568 C CG  . PRO B 2 11  ? 110.757 130.519 175.364 1.00 33.86  ? 34  PRO P CG  1 
ATOM   5569 C CD  . PRO B 2 11  ? 111.498 129.317 174.844 1.00 33.91  ? 34  PRO P CD  1 
ATOM   5570 N N   . PRO B 2 12  ? 114.683 130.334 176.858 1.00 26.89  ? 35  PRO P N   1 
ATOM   5571 C CA  . PRO B 2 12  ? 115.911 130.529 177.647 1.00 27.16  ? 35  PRO P CA  1 
ATOM   5572 C C   . PRO B 2 12  ? 117.186 130.487 176.825 1.00 25.23  ? 35  PRO P C   1 
ATOM   5573 O O   . PRO B 2 12  ? 118.138 131.205 177.153 1.00 34.11  ? 35  PRO P O   1 
ATOM   5574 C CB  . PRO B 2 12  ? 115.863 129.384 178.667 1.00 33.69  ? 35  PRO P CB  1 
ATOM   5575 C CG  . PRO B 2 12  ? 115.046 128.350 178.021 1.00 38.06  ? 35  PRO P CG  1 
ATOM   5576 C CD  . PRO B 2 12  ? 113.988 129.104 177.286 1.00 36.55  ? 35  PRO P CD  1 
ATOM   5577 N N   . GLU B 2 13  ? 117.242 129.677 175.768 1.00 28.59  ? 36  GLU P N   1 
ATOM   5578 C CA  . GLU B 2 13  ? 118.481 129.526 175.014 1.00 33.49  ? 36  GLU P CA  1 
ATOM   5579 C C   . GLU B 2 13  ? 118.684 130.624 173.978 1.00 33.99  ? 36  GLU P C   1 
ATOM   5580 O O   . GLU B 2 13  ? 119.812 130.814 173.511 1.00 36.64  ? 36  GLU P O   1 
ATOM   5581 C CB  . GLU B 2 13  ? 118.511 128.157 174.330 1.00 37.78  ? 36  GLU P CB  1 
ATOM   5582 C CG  . GLU B 2 13  ? 119.888 127.719 173.855 1.00 39.93  ? 36  GLU P CG  1 
ATOM   5583 C CD  . GLU B 2 13  ? 119.880 126.332 173.242 1.00 46.78  ? 36  GLU P CD  1 
ATOM   5584 O OE1 . GLU B 2 13  ? 118.794 125.721 173.160 1.00 45.53  ? 36  GLU P OE1 1 
ATOM   5585 O OE2 . GLU B 2 13  ? 120.961 125.851 172.842 1.00 46.58  ? 36  GLU P OE2 1 
ATOM   5586 N N   . ALA B 2 14  ? 117.634 131.358 173.621 1.00 28.26  ? 37  ALA P N   1 
ATOM   5587 C CA  . ALA B 2 14  ? 117.746 132.387 172.598 1.00 21.13  ? 37  ALA P CA  1 
ATOM   5588 C C   . ALA B 2 14  ? 118.108 133.752 173.159 1.00 28.88  ? 37  ALA P C   1 
ATOM   5589 O O   . ALA B 2 14  ? 118.499 134.637 172.390 1.00 35.72  ? 37  ALA P O   1 
ATOM   5590 C CB  . ALA B 2 14  ? 116.436 132.498 171.814 1.00 29.27  ? 37  ALA P CB  1 
ATOM   5591 N N   . GLN B 2 15  ? 117.991 133.946 174.471 1.00 29.62  ? 38  GLN P N   1 
ATOM   5592 C CA  . GLN B 2 15  ? 118.277 135.226 175.103 1.00 24.78  ? 38  GLN P CA  1 
ATOM   5593 C C   . GLN B 2 15  ? 119.560 135.203 175.923 1.00 32.09  ? 38  GLN P C   1 
ATOM   5594 O O   . GLN B 2 15  ? 119.818 136.146 176.677 1.00 40.47  ? 38  GLN P O   1 
ATOM   5595 C CB  . GLN B 2 15  ? 117.099 135.653 175.978 1.00 25.05  ? 38  GLN P CB  1 
ATOM   5596 C CG  . GLN B 2 15  ? 115.832 135.945 175.198 1.00 26.55  ? 38  GLN P CG  1 
ATOM   5597 C CD  . GLN B 2 15  ? 114.604 136.002 176.079 1.00 34.05  ? 38  GLN P CD  1 
ATOM   5598 O OE1 . GLN B 2 15  ? 113.555 136.499 175.670 1.00 40.59  ? 38  GLN P OE1 1 
ATOM   5599 N NE2 . GLN B 2 15  ? 114.726 135.490 177.296 1.00 33.55  ? 38  GLN P NE2 1 
ATOM   5600 N N   . SER B 2 16  ? 120.367 134.153 175.799 1.00 28.40  ? 39  SER P N   1 
ATOM   5601 C CA  . SER B 2 16  ? 121.649 134.078 176.496 1.00 21.87  ? 39  SER P CA  1 
ATOM   5602 C C   . SER B 2 16  ? 122.631 134.997 175.782 1.00 29.80  ? 39  SER P C   1 
ATOM   5603 O O   . SER B 2 16  ? 123.281 134.600 174.813 1.00 34.26  ? 39  SER P O   1 
ATOM   5604 C CB  . SER B 2 16  ? 122.159 132.643 176.536 1.00 25.52  ? 39  SER P CB  1 
ATOM   5605 O OG  . SER B 2 16  ? 122.365 132.139 175.228 1.00 35.29  ? 39  SER P OG  1 
ATOM   5606 N N   . PHE B 2 17  ? 122.740 136.236 176.264 1.00 32.49  ? 40  PHE P N   1 
ATOM   5607 C CA  . PHE B 2 17  ? 123.600 137.212 175.603 1.00 26.24  ? 40  PHE P CA  1 
ATOM   5608 C C   . PHE B 2 17  ? 125.073 136.905 175.839 1.00 28.67  ? 40  PHE P C   1 
ATOM   5609 O O   . PHE B 2 17  ? 125.881 136.958 174.905 1.00 37.91  ? 40  PHE P O   1 
ATOM   5610 C CB  . PHE B 2 17  ? 123.255 138.620 176.087 1.00 27.36  ? 40  PHE P CB  1 
ATOM   5611 C CG  . PHE B 2 17  ? 123.913 139.714 175.297 1.00 24.06  ? 40  PHE P CG  1 
ATOM   5612 C CD1 . PHE B 2 17  ? 123.407 140.094 174.068 1.00 30.06  ? 40  PHE P CD1 1 
ATOM   5613 C CD2 . PHE B 2 17  ? 125.026 140.370 175.786 1.00 26.10  ? 40  PHE P CD2 1 
ATOM   5614 C CE1 . PHE B 2 17  ? 124.006 141.101 173.340 1.00 31.53  ? 40  PHE P CE1 1 
ATOM   5615 C CE2 . PHE B 2 17  ? 125.628 141.377 175.062 1.00 25.80  ? 40  PHE P CE2 1 
ATOM   5616 C CZ  . PHE B 2 17  ? 125.117 141.742 173.839 1.00 28.12  ? 40  PHE P CZ  1 
ATOM   5617 N N   . LEU B 2 18  ? 125.440 136.578 177.075 1.00 32.47  ? 41  LEU P N   1 
ATOM   5618 C CA  . LEU B 2 18  ? 126.834 136.364 177.446 1.00 31.59  ? 41  LEU P CA  1 
ATOM   5619 C C   . LEU B 2 18  ? 127.181 134.891 177.267 1.00 36.79  ? 41  LEU P C   1 
ATOM   5620 O O   . LEU B 2 18  ? 126.714 134.038 178.030 1.00 40.81  ? 41  LEU P O   1 
ATOM   5621 C CB  . LEU B 2 18  ? 127.080 136.808 178.885 1.00 31.66  ? 41  LEU P CB  1 
ATOM   5622 C CG  . LEU B 2 18  ? 126.728 138.251 179.234 1.00 33.46  ? 41  LEU P CG  1 
ATOM   5623 C CD1 . LEU B 2 18  ? 126.911 138.494 180.721 1.00 34.04  ? 41  LEU P CD1 1 
ATOM   5624 C CD2 . LEU B 2 18  ? 127.572 139.220 178.424 1.00 35.77  ? 41  LEU P CD2 1 
ATOM   5625 N N   . SER B 2 19  ? 127.999 134.590 176.262 1.00 60.26  ? 42  SER P N   1 
ATOM   5626 C CA  . SER B 2 19  ? 128.543 133.254 176.057 1.00 65.82  ? 42  SER P CA  1 
ATOM   5627 C C   . SER B 2 19  ? 130.051 133.321 176.244 1.00 69.92  ? 42  SER P C   1 
ATOM   5628 O O   . SER B 2 19  ? 130.741 134.023 175.496 1.00 69.42  ? 42  SER P O   1 
ATOM   5629 C CB  . SER B 2 19  ? 128.189 132.718 174.669 1.00 67.34  ? 42  SER P CB  1 
ATOM   5630 O OG  . SER B 2 19  ? 128.723 133.546 173.650 1.00 68.19  ? 42  SER P OG  1 
ATOM   5631 N N   . SER B 2 20  ? 130.558 132.595 177.236 1.00 93.81  ? 43  SER P N   1 
ATOM   5632 C CA  . SER B 2 20  ? 131.975 132.626 177.569 1.00 95.45  ? 43  SER P CA  1 
ATOM   5633 C C   . SER B 2 20  ? 132.742 131.657 176.669 1.00 95.82  ? 43  SER P C   1 
ATOM   5634 O O   . SER B 2 20  ? 132.188 131.049 175.749 1.00 94.32  ? 43  SER P O   1 
ATOM   5635 C CB  . SER B 2 20  ? 132.176 132.310 179.048 1.00 94.47  ? 43  SER P CB  1 
ATOM   5636 O OG  . SER B 2 20  ? 133.550 132.344 179.395 1.00 96.27  ? 43  SER P OG  1 
ATOM   5637 N N   . HIS B 2 21  ? 134.037 131.504 176.933 1.00 110.15 ? 44  HIS P N   1 
ATOM   5638 C CA  . HIS B 2 21  ? 134.863 130.558 176.201 1.00 110.97 ? 44  HIS P CA  1 
ATOM   5639 C C   . HIS B 2 21  ? 134.631 129.143 176.728 1.00 111.48 ? 44  HIS P C   1 
ATOM   5640 O O   . HIS B 2 21  ? 133.796 128.907 177.606 1.00 110.99 ? 44  HIS P O   1 
ATOM   5641 C CB  . HIS B 2 21  ? 136.337 130.956 176.285 1.00 111.37 ? 44  HIS P CB  1 
ATOM   5642 C CG  . HIS B 2 21  ? 136.850 131.122 177.683 1.00 111.88 ? 44  HIS P CG  1 
ATOM   5643 N ND1 . HIS B 2 21  ? 136.122 130.767 178.798 1.00 111.35 ? 44  HIS P ND1 1 
ATOM   5644 C CD2 . HIS B 2 21  ? 138.027 131.610 178.144 1.00 111.51 ? 44  HIS P CD2 1 
ATOM   5645 C CE1 . HIS B 2 21  ? 136.826 131.027 179.885 1.00 110.75 ? 44  HIS P CE1 1 
ATOM   5646 N NE2 . HIS B 2 21  ? 137.986 131.539 179.516 1.00 111.46 ? 44  HIS P NE2 1 
ATOM   5647 N N   . THR B 2 22  ? 135.390 128.190 176.184 1.00 116.09 ? 45  THR P N   1 
ATOM   5648 C CA  . THR B 2 22  ? 135.221 126.768 176.491 1.00 115.90 ? 45  THR P CA  1 
ATOM   5649 C C   . THR B 2 22  ? 133.774 126.336 176.260 1.00 116.20 ? 45  THR P C   1 
ATOM   5650 O O   . THR B 2 22  ? 133.178 125.609 177.058 1.00 116.24 ? 45  THR P O   1 
ATOM   5651 C CB  . THR B 2 22  ? 135.671 126.451 177.920 1.00 115.46 ? 45  THR P CB  1 
ATOM   5652 O OG1 . THR B 2 22  ? 136.783 127.286 178.266 1.00 115.05 ? 45  THR P OG1 1 
ATOM   5653 C CG2 . THR B 2 22  ? 136.099 124.993 178.036 1.00 114.69 ? 45  THR P CG2 1 
ATOM   5654 N N   . ARG B 2 23  ? 133.203 126.801 175.154 1.00 114.26 ? 46  ARG P N   1 
ATOM   5655 C CA  . ARG B 2 23  ? 131.810 126.525 174.824 1.00 114.74 ? 46  ARG P CA  1 
ATOM   5656 C C   . ARG B 2 23  ? 131.702 125.507 173.695 1.00 114.09 ? 46  ARG P C   1 
ATOM   5657 O O   . ARG B 2 23  ? 132.046 125.797 172.549 1.00 113.36 ? 46  ARG P O   1 
ATOM   5658 C CB  . ARG B 2 23  ? 131.093 127.821 174.438 1.00 113.68 ? 46  ARG P CB  1 
ATOM   5659 C CG  . ARG B 2 23  ? 129.657 127.634 173.981 1.00 113.32 ? 46  ARG P CG  1 
ATOM   5660 C CD  . ARG B 2 23  ? 129.034 128.954 173.542 1.00 112.89 ? 46  ARG P CD  1 
ATOM   5661 N NE  . ARG B 2 23  ? 129.697 129.521 172.372 1.00 113.54 ? 46  ARG P NE  1 
ATOM   5662 C CZ  . ARG B 2 23  ? 130.592 130.498 172.416 1.00 113.70 ? 46  ARG P CZ  1 
ATOM   5663 N NH1 . ARG B 2 23  ? 130.958 131.051 173.560 1.00 112.74 ? 46  ARG P NH1 1 
ATOM   5664 N NH2 . ARG B 2 23  ? 131.135 130.931 171.281 1.00 113.92 ? 46  ARG P NH2 1 
ATOM   5665 N N   . LEU B 2 63  ? 139.776 134.490 167.529 1.00 131.71 ? 86  LEU P N   1 
ATOM   5666 C CA  . LEU B 2 63  ? 140.184 135.504 166.564 1.00 132.74 ? 86  LEU P CA  1 
ATOM   5667 C C   . LEU B 2 63  ? 139.171 136.642 166.506 1.00 133.11 ? 86  LEU P C   1 
ATOM   5668 O O   . LEU B 2 63  ? 139.475 137.773 166.890 1.00 133.40 ? 86  LEU P O   1 
ATOM   5669 C CB  . LEU B 2 63  ? 140.361 134.884 165.177 1.00 132.56 ? 86  LEU P CB  1 
ATOM   5670 C CG  . LEU B 2 63  ? 140.805 135.831 164.061 1.00 132.04 ? 86  LEU P CG  1 
ATOM   5671 C CD1 . LEU B 2 63  ? 142.156 136.451 164.386 1.00 131.38 ? 86  LEU P CD1 1 
ATOM   5672 C CD2 . LEU B 2 63  ? 140.852 135.105 162.725 1.00 131.93 ? 86  LEU P CD2 1 
ATOM   5673 N N   . THR B 2 64  ? 137.966 136.327 166.028 1.00 133.92 ? 87  THR P N   1 
ATOM   5674 C CA  . THR B 2 64  ? 136.878 137.296 165.881 1.00 134.06 ? 87  THR P CA  1 
ATOM   5675 C C   . THR B 2 64  ? 137.334 138.516 165.081 1.00 133.81 ? 87  THR P C   1 
ATOM   5676 O O   . THR B 2 64  ? 137.086 139.666 165.449 1.00 133.71 ? 87  THR P O   1 
ATOM   5677 C CB  . THR B 2 64  ? 136.317 137.712 167.244 1.00 134.07 ? 87  THR P CB  1 
ATOM   5678 O OG1 . THR B 2 64  ? 137.297 138.475 167.958 1.00 134.12 ? 87  THR P OG1 1 
ATOM   5679 C CG2 . THR B 2 64  ? 135.943 136.484 168.061 1.00 133.25 ? 87  THR P CG2 1 
ATOM   5680 N N   . GLU B 2 65  ? 138.012 138.249 163.969 1.00 120.95 ? 88  GLU P N   1 
ATOM   5681 C CA  . GLU B 2 65  ? 138.564 139.278 163.094 1.00 119.87 ? 88  GLU P CA  1 
ATOM   5682 C C   . GLU B 2 65  ? 138.233 138.967 161.640 1.00 119.02 ? 88  GLU P C   1 
ATOM   5683 O O   . GLU B 2 65  ? 139.094 139.002 160.758 1.00 118.92 ? 88  GLU P O   1 
ATOM   5684 C CB  . GLU B 2 65  ? 140.072 139.410 163.294 1.00 119.29 ? 88  GLU P CB  1 
ATOM   5685 C CG  . GLU B 2 65  ? 140.543 140.833 163.551 1.00 119.26 ? 88  GLU P CG  1 
ATOM   5686 C CD  . GLU B 2 65  ? 140.110 141.358 164.907 1.00 120.03 ? 88  GLU P CD  1 
ATOM   5687 O OE1 . GLU B 2 65  ? 139.838 140.536 165.808 1.00 120.84 ? 88  GLU P OE1 1 
ATOM   5688 O OE2 . GLU B 2 65  ? 140.039 142.594 165.072 1.00 118.89 ? 88  GLU P OE2 1 
ATOM   5689 N N   . ARG B 2 66  ? 136.968 138.631 161.385 1.00 102.88 ? 89  ARG P N   1 
ATOM   5690 C CA  . ARG B 2 66  ? 136.519 138.298 160.038 1.00 102.20 ? 89  ARG P CA  1 
ATOM   5691 C C   . ARG B 2 66  ? 136.843 139.432 159.072 1.00 102.59 ? 89  ARG P C   1 
ATOM   5692 O O   . ARG B 2 66  ? 136.372 140.560 159.241 1.00 101.40 ? 89  ARG P O   1 
ATOM   5693 C CB  . ARG B 2 66  ? 135.017 138.009 160.047 1.00 101.08 ? 89  ARG P CB  1 
ATOM   5694 C CG  . ARG B 2 66  ? 134.500 137.297 158.803 1.00 100.80 ? 89  ARG P CG  1 
ATOM   5695 C CD  . ARG B 2 66  ? 133.959 138.275 157.771 1.00 100.45 ? 89  ARG P CD  1 
ATOM   5696 N NE  . ARG B 2 66  ? 132.817 139.026 158.278 1.00 100.88 ? 89  ARG P NE  1 
ATOM   5697 C CZ  . ARG B 2 66  ? 131.557 138.622 158.189 1.00 101.84 ? 89  ARG P CZ  1 
ATOM   5698 N NH1 . ARG B 2 66  ? 131.238 137.473 157.617 1.00 102.43 ? 89  ARG P NH1 1 
ATOM   5699 N NH2 . ARG B 2 66  ? 130.593 139.391 158.688 1.00 100.65 ? 89  ARG P NH2 1 
ATOM   5700 N N   . PHE B 2 67  ? 137.652 139.124 158.058 1.00 99.96  ? 90  PHE P N   1 
ATOM   5701 C CA  . PHE B 2 67  ? 138.179 140.122 157.136 1.00 98.14  ? 90  PHE P CA  1 
ATOM   5702 C C   . PHE B 2 67  ? 137.524 140.074 155.763 1.00 96.04  ? 90  PHE P C   1 
ATOM   5703 O O   . PHE B 2 67  ? 138.046 140.680 154.821 1.00 97.79  ? 90  PHE P O   1 
ATOM   5704 C CB  . PHE B 2 67  ? 139.694 139.953 156.997 1.00 98.01  ? 90  PHE P CB  1 
ATOM   5705 C CG  . PHE B 2 67  ? 140.489 140.938 157.802 1.00 98.83  ? 90  PHE P CG  1 
ATOM   5706 C CD1 . PHE B 2 67  ? 140.159 142.281 157.796 1.00 97.95  ? 90  PHE P CD1 1 
ATOM   5707 C CD2 . PHE B 2 67  ? 141.566 140.521 158.565 1.00 99.39  ? 90  PHE P CD2 1 
ATOM   5708 C CE1 . PHE B 2 67  ? 140.889 143.192 158.532 1.00 98.47  ? 90  PHE P CE1 1 
ATOM   5709 C CE2 . PHE B 2 67  ? 142.300 141.427 159.306 1.00 99.68  ? 90  PHE P CE2 1 
ATOM   5710 C CZ  . PHE B 2 67  ? 141.960 142.765 159.290 1.00 99.71  ? 90  PHE P CZ  1 
ATOM   5711 N N   . TRP B 2 68  ? 136.406 139.358 155.621 1.00 85.54  ? 91  TRP P N   1 
ATOM   5712 C CA  . TRP B 2 68  ? 135.645 139.301 154.376 1.00 83.58  ? 91  TRP P CA  1 
ATOM   5713 C C   . TRP B 2 68  ? 136.471 138.715 153.237 1.00 85.35  ? 91  TRP P C   1 
ATOM   5714 O O   . TRP B 2 68  ? 136.156 137.635 152.726 1.00 88.21  ? 91  TRP P O   1 
ATOM   5715 C CB  . TRP B 2 68  ? 135.135 140.692 153.987 1.00 84.13  ? 91  TRP P CB  1 
ATOM   5716 C CG  . TRP B 2 68  ? 134.376 141.391 155.067 1.00 86.73  ? 91  TRP P CG  1 
ATOM   5717 C CD1 . TRP B 2 68  ? 134.900 142.058 156.137 1.00 88.47  ? 91  TRP P CD1 1 
ATOM   5718 C CD2 . TRP B 2 68  ? 132.954 141.511 155.178 1.00 87.76  ? 91  TRP P CD2 1 
ATOM   5719 N NE1 . TRP B 2 68  ? 133.892 142.578 156.911 1.00 89.09  ? 91  TRP P NE1 1 
ATOM   5720 C CE2 . TRP B 2 68  ? 132.687 142.256 156.344 1.00 89.11  ? 91  TRP P CE2 1 
ATOM   5721 C CE3 . TRP B 2 68  ? 131.880 141.057 154.408 1.00 87.76  ? 91  TRP P CE3 1 
ATOM   5722 C CZ2 . TRP B 2 68  ? 131.392 142.558 156.757 1.00 88.49  ? 91  TRP P CZ2 1 
ATOM   5723 C CZ3 . TRP B 2 68  ? 130.594 141.358 154.820 1.00 88.59  ? 91  TRP P CZ3 1 
ATOM   5724 C CH2 . TRP B 2 68  ? 130.362 142.101 155.983 1.00 88.46  ? 91  TRP P CH2 1 
ATOM   5725 N N   . GLU B 2 69  ? 137.527 139.421 152.832 1.00 70.67  ? 92  GLU P N   1 
ATOM   5726 C CA  . GLU B 2 69  ? 138.371 139.001 151.713 1.00 66.74  ? 92  GLU P CA  1 
ATOM   5727 C C   . GLU B 2 69  ? 139.306 137.879 152.167 1.00 68.15  ? 92  GLU P C   1 
ATOM   5728 O O   . GLU B 2 69  ? 140.517 138.045 152.328 1.00 70.45  ? 92  GLU P O   1 
ATOM   5729 C CB  . GLU B 2 69  ? 139.145 140.186 151.157 1.00 65.57  ? 92  GLU P CB  1 
ATOM   5730 C CG  . GLU B 2 69  ? 140.076 139.835 150.011 1.00 67.68  ? 92  GLU P CG  1 
ATOM   5731 C CD  . GLU B 2 69  ? 140.441 141.038 149.170 1.00 71.28  ? 92  GLU P CD  1 
ATOM   5732 O OE1 . GLU B 2 69  ? 139.805 142.099 149.342 1.00 71.80  ? 92  GLU P OE1 1 
ATOM   5733 O OE2 . GLU B 2 69  ? 141.365 140.925 148.339 1.00 71.69  ? 92  GLU P OE2 1 
ATOM   5734 N N   . SER B 2 70  ? 138.708 136.710 152.385 1.00 68.08  ? 93  SER P N   1 
ATOM   5735 C CA  . SER B 2 70  ? 139.472 135.510 152.716 1.00 66.14  ? 93  SER P CA  1 
ATOM   5736 C C   . SER B 2 70  ? 138.614 134.309 152.347 1.00 69.31  ? 93  SER P C   1 
ATOM   5737 O O   . SER B 2 70  ? 137.571 134.082 152.968 1.00 72.03  ? 93  SER P O   1 
ATOM   5738 C CB  . SER B 2 70  ? 139.852 135.490 154.191 1.00 68.97  ? 93  SER P CB  1 
ATOM   5739 O OG  . SER B 2 70  ? 140.760 136.534 154.498 1.00 68.99  ? 93  SER P OG  1 
ATOM   5740 N N   . TYR B 2 71  ? 139.046 133.556 151.339 1.00 98.65  ? 94  TYR P N   1 
ATOM   5741 C CA  . TYR B 2 71  ? 138.294 132.388 150.904 1.00 100.56 ? 94  TYR P CA  1 
ATOM   5742 C C   . TYR B 2 71  ? 138.198 131.369 152.033 1.00 103.16 ? 94  TYR P C   1 
ATOM   5743 O O   . TYR B 2 71  ? 139.159 131.140 152.772 1.00 104.53 ? 94  TYR P O   1 
ATOM   5744 C CB  . TYR B 2 71  ? 138.951 131.777 149.663 1.00 102.24 ? 94  TYR P CB  1 
ATOM   5745 C CG  . TYR B 2 71  ? 139.454 130.359 149.824 1.00 104.34 ? 94  TYR P CG  1 
ATOM   5746 C CD1 . TYR B 2 71  ? 140.741 130.105 150.282 1.00 103.78 ? 94  TYR P CD1 1 
ATOM   5747 C CD2 . TYR B 2 71  ? 138.651 129.275 149.493 1.00 104.34 ? 94  TYR P CD2 1 
ATOM   5748 C CE1 . TYR B 2 71  ? 141.207 128.811 150.423 1.00 103.71 ? 94  TYR P CE1 1 
ATOM   5749 C CE2 . TYR B 2 71  ? 139.109 127.978 149.630 1.00 104.01 ? 94  TYR P CE2 1 
ATOM   5750 C CZ  . TYR B 2 71  ? 140.387 127.752 150.095 1.00 104.27 ? 94  TYR P CZ  1 
ATOM   5751 O OH  . TYR B 2 71  ? 140.846 126.461 150.232 1.00 103.28 ? 94  TYR P OH  1 
ATOM   5752 N N   . ILE B 2 72  ? 137.021 130.766 152.172 1.00 107.96 ? 95  ILE P N   1 
ATOM   5753 C CA  . ILE B 2 72  ? 136.761 129.836 153.266 1.00 108.57 ? 95  ILE P CA  1 
ATOM   5754 C C   . ILE B 2 72  ? 137.307 128.466 152.883 1.00 108.27 ? 95  ILE P C   1 
ATOM   5755 O O   . ILE B 2 72  ? 136.921 127.896 151.857 1.00 107.82 ? 95  ILE P O   1 
ATOM   5756 C CB  . ILE B 2 72  ? 135.262 129.763 153.592 1.00 107.74 ? 95  ILE P CB  1 
ATOM   5757 C CG1 . ILE B 2 72  ? 134.794 131.039 154.301 1.00 106.63 ? 95  ILE P CG1 1 
ATOM   5758 C CG2 . ILE B 2 72  ? 134.960 128.541 154.448 1.00 106.96 ? 95  ILE P CG2 1 
ATOM   5759 C CD1 . ILE B 2 72  ? 134.429 132.179 153.370 1.00 105.53 ? 95  ILE P CD1 1 
ATOM   5760 N N   . TYR B 2 73  ? 138.203 127.935 153.712 1.00 115.54 ? 96  TYR P N   1 
ATOM   5761 C CA  . TYR B 2 73  ? 138.814 126.641 153.437 1.00 116.26 ? 96  TYR P CA  1 
ATOM   5762 C C   . TYR B 2 73  ? 137.789 125.531 153.643 1.00 117.07 ? 96  TYR P C   1 
ATOM   5763 O O   . TYR B 2 73  ? 137.294 125.332 154.757 1.00 116.08 ? 96  TYR P O   1 
ATOM   5764 C CB  . TYR B 2 73  ? 140.026 126.429 154.340 1.00 115.92 ? 96  TYR P CB  1 
ATOM   5765 C CG  . TYR B 2 73  ? 141.033 125.441 153.797 1.00 116.79 ? 96  TYR P CG  1 
ATOM   5766 C CD1 . TYR B 2 73  ? 140.882 124.076 154.008 1.00 115.47 ? 96  TYR P CD1 1 
ATOM   5767 C CD2 . TYR B 2 73  ? 142.137 125.874 153.074 1.00 116.52 ? 96  TYR P CD2 1 
ATOM   5768 C CE1 . TYR B 2 73  ? 141.801 123.171 153.512 1.00 115.36 ? 96  TYR P CE1 1 
ATOM   5769 C CE2 . TYR B 2 73  ? 143.061 124.977 152.574 1.00 115.71 ? 96  TYR P CE2 1 
ATOM   5770 C CZ  . TYR B 2 73  ? 142.888 123.627 152.796 1.00 115.61 ? 96  TYR P CZ  1 
ATOM   5771 O OH  . TYR B 2 73  ? 143.808 122.733 152.300 1.00 115.25 ? 96  TYR P OH  1 
ATOM   5772 N N   . ASN B 2 74  ? 137.472 124.810 152.570 1.00 121.46 ? 97  ASN P N   1 
ATOM   5773 C CA  . ASN B 2 74  ? 136.486 123.734 152.637 1.00 121.37 ? 97  ASN P CA  1 
ATOM   5774 C C   . ASN B 2 74  ? 136.750 122.768 151.494 1.00 121.61 ? 97  ASN P C   1 
ATOM   5775 O O   . ASN B 2 74  ? 136.720 123.170 150.326 1.00 120.24 ? 97  ASN P O   1 
ATOM   5776 C CB  . ASN B 2 74  ? 135.063 124.291 152.561 1.00 120.41 ? 97  ASN P CB  1 
ATOM   5777 C CG  . ASN B 2 74  ? 134.007 123.207 152.653 1.00 120.65 ? 97  ASN P CG  1 
ATOM   5778 O OD1 . ASN B 2 74  ? 133.597 122.814 153.745 1.00 120.62 ? 97  ASN P OD1 1 
ATOM   5779 N ND2 . ASN B 2 74  ? 133.559 122.718 151.502 1.00 120.52 ? 97  ASN P ND2 1 
ATOM   5780 N N   . GLY B 2 75  ? 137.005 121.507 151.825 1.00 124.23 ? 98  GLY P N   1 
ATOM   5781 C CA  . GLY B 2 75  ? 137.269 120.494 150.820 1.00 123.93 ? 98  GLY P CA  1 
ATOM   5782 C C   . GLY B 2 75  ? 136.086 119.581 150.564 1.00 123.54 ? 98  GLY P C   1 
ATOM   5783 O O   . GLY B 2 75  ? 136.225 118.527 149.944 1.00 122.83 ? 98  GLY P O   1 
HETATM 5784 C C1  . NAG C 3 .   ? 111.118 149.214 185.872 1.00 59.36  ? 1   NAG B C1  1 
HETATM 5785 C C2  . NAG C 3 .   ? 109.630 148.910 185.723 1.00 53.67  ? 1   NAG B C2  1 
HETATM 5786 C C3  . NAG C 3 .   ? 109.228 148.942 184.252 1.00 55.76  ? 1   NAG B C3  1 
HETATM 5787 C C4  . NAG C 3 .   ? 109.639 150.265 183.620 1.00 58.26  ? 1   NAG B C4  1 
HETATM 5788 C C5  . NAG C 3 .   ? 111.127 150.510 183.847 1.00 62.37  ? 1   NAG B C5  1 
HETATM 5789 C C6  . NAG C 3 .   ? 111.589 151.857 183.344 1.00 62.34  ? 1   NAG B C6  1 
HETATM 5790 C C7  . NAG C 3 .   ? 108.421 147.486 187.315 1.00 64.34  ? 1   NAG B C7  1 
HETATM 5791 C C8  . NAG C 3 .   ? 108.199 146.087 187.805 1.00 64.60  ? 1   NAG B C8  1 
HETATM 5792 N N2  . NAG C 3 .   ? 109.298 147.625 186.316 1.00 57.98  ? 1   NAG B N2  1 
HETATM 5793 O O3  . NAG C 3 .   ? 107.821 148.764 184.141 1.00 64.66  ? 1   NAG B O3  1 
HETATM 5794 O O4  . NAG C 3 .   ? 109.366 150.249 182.224 1.00 61.34  ? 1   NAG B O4  1 
HETATM 5795 O O5  . NAG C 3 .   ? 111.417 150.469 185.252 1.00 66.23  ? 1   NAG B O5  1 
HETATM 5796 O O6  . NAG C 3 .   ? 110.692 152.389 182.379 1.00 61.36  ? 1   NAG B O6  1 
HETATM 5797 O O7  . NAG C 3 .   ? 107.832 148.447 187.800 1.00 64.97  ? 1   NAG B O7  1 
HETATM 5798 C C1  . NAG C 3 .   ? 108.549 150.838 181.323 1.00 68.64  ? 2   NAG B C1  1 
HETATM 5799 C C2  . NAG C 3 .   ? 108.262 151.562 180.011 1.00 67.00  ? 2   NAG B C2  1 
HETATM 5800 C C3  . NAG C 3 .   ? 106.773 151.866 179.891 1.00 72.19  ? 2   NAG B C3  1 
HETATM 5801 C C4  . NAG C 3 .   ? 105.953 150.596 180.079 1.00 78.09  ? 2   NAG B C4  1 
HETATM 5802 C C5  . NAG C 3 .   ? 106.341 149.905 181.384 1.00 79.06  ? 2   NAG B C5  1 
HETATM 5803 C C6  . NAG C 3 .   ? 105.659 148.570 181.572 1.00 75.95  ? 2   NAG B C6  1 
HETATM 5804 C C7  . NAG C 3 .   ? 109.590 153.208 178.763 1.00 74.52  ? 2   NAG B C7  1 
HETATM 5805 C C8  . NAG C 3 .   ? 110.363 154.490 178.840 1.00 73.07  ? 2   NAG B C8  1 
HETATM 5806 N N2  . NAG C 3 .   ? 109.043 152.785 179.907 1.00 69.59  ? 2   NAG B N2  1 
HETATM 5807 O O3  . NAG C 3 .   ? 106.506 152.431 178.613 1.00 73.74  ? 2   NAG B O3  1 
HETATM 5808 O O4  . NAG C 3 .   ? 104.566 150.911 180.110 1.00 76.31  ? 2   NAG B O4  1 
HETATM 5809 O O5  . NAG C 3 .   ? 107.754 149.655 181.402 1.00 77.65  ? 2   NAG B O5  1 
HETATM 5810 O O6  . NAG C 3 .   ? 105.064 148.468 182.858 1.00 70.19  ? 2   NAG B O6  1 
HETATM 5811 O O7  . NAG C 3 .   ? 109.468 152.584 177.715 1.00 77.96  ? 2   NAG B O7  1 
HETATM 5812 C C1  . NAG D 3 .   ? 133.532 137.971 190.900 1.00 65.70  ? 1   NAG C C1  1 
HETATM 5813 C C2  . NAG D 3 .   ? 134.604 137.454 191.843 1.00 62.88  ? 1   NAG C C2  1 
HETATM 5814 C C3  . NAG D 3 .   ? 135.991 137.646 191.235 1.00 67.40  ? 1   NAG C C3  1 
HETATM 5815 C C4  . NAG D 3 .   ? 136.202 139.075 190.746 1.00 67.58  ? 1   NAG C C4  1 
HETATM 5816 C C5  . NAG D 3 .   ? 135.009 139.615 189.952 1.00 71.98  ? 1   NAG C C5  1 
HETATM 5817 C C6  . NAG D 3 .   ? 134.906 139.044 188.557 1.00 73.00  ? 1   NAG C C6  1 
HETATM 5818 C C7  . NAG D 3 .   ? 133.698 137.700 194.110 1.00 69.24  ? 1   NAG C C7  1 
HETATM 5819 C C8  . NAG D 3 .   ? 133.741 138.493 195.382 1.00 67.70  ? 1   NAG C C8  1 
HETATM 5820 N N2  . NAG D 3 .   ? 134.519 138.109 193.138 1.00 63.24  ? 1   NAG C N2  1 
HETATM 5821 O O3  . NAG D 3 .   ? 136.179 136.721 190.169 1.00 73.05  ? 1   NAG C O3  1 
HETATM 5822 O O4  . NAG D 3 .   ? 136.444 139.931 191.856 1.00 70.08  ? 1   NAG C O4  1 
HETATM 5823 O O5  . NAG D 3 .   ? 133.765 139.335 190.614 1.00 73.32  ? 1   NAG C O5  1 
HETATM 5824 O O6  . NAG D 3 .   ? 133.649 139.344 187.965 1.00 73.36  ? 1   NAG C O6  1 
HETATM 5825 O O7  . NAG D 3 .   ? 132.957 136.734 193.971 1.00 68.41  ? 1   NAG C O7  1 
HETATM 5826 C C1  . NAG D 3 .   ? 137.701 140.431 192.000 1.00 90.69  ? 2   NAG C C1  1 
HETATM 5827 C C2  . NAG D 3 .   ? 138.392 141.770 191.755 1.00 87.35  ? 2   NAG C C2  1 
HETATM 5828 C C3  . NAG D 3 .   ? 139.895 141.636 191.979 1.00 88.04  ? 2   NAG C C3  1 
HETATM 5829 C C4  . NAG D 3 .   ? 140.179 141.046 193.354 1.00 89.67  ? 2   NAG C C4  1 
HETATM 5830 C C5  . NAG D 3 .   ? 139.406 139.743 193.541 1.00 91.45  ? 2   NAG C C5  1 
HETATM 5831 C C6  . NAG D 3 .   ? 139.538 139.173 194.934 1.00 89.65  ? 2   NAG C C6  1 
HETATM 5832 C C7  . NAG D 3 .   ? 137.483 143.413 190.172 1.00 89.39  ? 2   NAG C C7  1 
HETATM 5833 C C8  . NAG D 3 .   ? 137.055 144.197 191.377 1.00 86.67  ? 2   NAG C C8  1 
HETATM 5834 N N2  . NAG D 3 .   ? 138.117 142.261 190.415 1.00 87.53  ? 2   NAG C N2  1 
HETATM 5835 O O3  . NAG D 3 .   ? 140.506 142.916 191.864 1.00 89.57  ? 2   NAG C O3  1 
HETATM 5836 O O4  . NAG D 3 .   ? 141.571 140.787 193.494 1.00 89.12  ? 2   NAG C O4  1 
HETATM 5837 O O5  . NAG D 3 .   ? 138.006 139.967 193.317 1.00 95.67  ? 2   NAG C O5  1 
HETATM 5838 O O6  . NAG D 3 .   ? 140.681 139.690 195.602 1.00 90.19  ? 2   NAG C O6  1 
HETATM 5839 O O7  . NAG D 3 .   ? 137.263 143.805 189.030 1.00 92.26  ? 2   NAG C O7  1 
HETATM 5840 C C1  . NAG E 3 .   ? 131.033 127.783 180.780 1.00 57.67  ? 1   NAG D C1  1 
HETATM 5841 C C2  . NAG E 3 .   ? 130.492 127.527 179.374 1.00 56.11  ? 1   NAG D C2  1 
HETATM 5842 C C3  . NAG E 3 .   ? 130.027 126.081 179.238 1.00 54.28  ? 1   NAG D C3  1 
HETATM 5843 C C4  . NAG E 3 .   ? 131.148 125.129 179.631 1.00 51.83  ? 1   NAG D C4  1 
HETATM 5844 C C5  . NAG E 3 .   ? 131.668 125.473 181.023 1.00 52.77  ? 1   NAG D C5  1 
HETATM 5845 C C6  . NAG E 3 .   ? 132.867 124.647 181.422 1.00 57.89  ? 1   NAG D C6  1 
HETATM 5846 C C7  . NAG E 3 .   ? 128.253 128.542 179.671 1.00 60.84  ? 1   NAG D C7  1 
HETATM 5847 C C8  . NAG E 3 .   ? 127.292 129.563 179.142 1.00 59.22  ? 1   NAG D C8  1 
HETATM 5848 N N2  . NAG E 3 .   ? 129.423 128.454 179.025 1.00 58.51  ? 1   NAG D N2  1 
HETATM 5849 O O3  . NAG E 3 .   ? 129.627 125.835 177.895 1.00 64.43  ? 1   NAG D O3  1 
HETATM 5850 O O4  . NAG E 3 .   ? 130.676 123.786 179.620 1.00 62.95  ? 1   NAG D O4  1 
HETATM 5851 O O5  . NAG E 3 .   ? 132.079 126.848 181.070 1.00 58.68  ? 1   NAG D O5  1 
HETATM 5852 O O6  . NAG E 3 .   ? 132.548 123.264 181.492 1.00 61.71  ? 1   NAG D O6  1 
HETATM 5853 O O7  . NAG E 3 .   ? 127.980 127.834 180.636 1.00 64.68  ? 1   NAG D O7  1 
HETATM 5854 C C1  . NAG E 3 .   ? 130.660 122.522 178.926 1.00 66.43  ? 2   NAG D C1  1 
HETATM 5855 C C2  . NAG E 3 .   ? 130.524 121.034 179.240 1.00 60.82  ? 2   NAG D C2  1 
HETATM 5856 C C3  . NAG E 3 .   ? 130.459 120.224 177.949 1.00 63.11  ? 2   NAG D C3  1 
HETATM 5857 C C4  . NAG E 3 .   ? 129.361 120.761 177.040 1.00 64.43  ? 2   NAG D C4  1 
HETATM 5858 C C5  . NAG E 3 .   ? 129.552 122.257 176.816 1.00 64.35  ? 2   NAG D C5  1 
HETATM 5859 C C6  . NAG E 3 .   ? 128.434 122.882 176.015 1.00 67.04  ? 2   NAG D C6  1 
HETATM 5860 C C7  . NAG E 3 .   ? 131.452 119.847 181.184 1.00 64.18  ? 2   NAG D C7  1 
HETATM 5861 C C8  . NAG E 3 .   ? 130.034 119.517 181.544 1.00 63.35  ? 2   NAG D C8  1 
HETATM 5862 N N2  . NAG E 3 .   ? 131.623 120.574 180.074 1.00 59.50  ? 2   NAG D N2  1 
HETATM 5863 O O3  . NAG E 3 .   ? 130.209 118.858 178.258 1.00 68.80  ? 2   NAG D O3  1 
HETATM 5864 O O4  . NAG E 3 .   ? 129.397 120.091 175.785 1.00 66.88  ? 2   NAG D O4  1 
HETATM 5865 O O5  . NAG E 3 .   ? 129.585 122.936 178.080 1.00 68.54  ? 2   NAG D O5  1 
HETATM 5866 O O6  . NAG E 3 .   ? 128.913 123.427 174.793 1.00 66.36  ? 2   NAG D O6  1 
HETATM 5867 O O7  . NAG E 3 .   ? 132.399 119.473 181.867 1.00 63.99  ? 2   NAG D O7  1 
HETATM 5868 C C22 . 6PL F 4 .   ? 153.106 161.503 134.666 0.60 52.52  ? 801 6PL A C22 1 
HETATM 5869 C C21 . 6PL F 4 .   ? 152.167 161.452 135.866 0.60 55.10  ? 801 6PL A C21 1 
HETATM 5870 C C20 . 6PL F 4 .   ? 151.961 160.043 136.410 0.60 54.90  ? 801 6PL A C20 1 
HETATM 5871 C C19 . 6PL F 4 .   ? 151.363 159.082 135.389 0.60 53.20  ? 801 6PL A C19 1 
HETATM 5872 C C18 . 6PL F 4 .   ? 151.010 157.721 135.977 0.60 54.94  ? 801 6PL A C18 1 
HETATM 5873 C C17 . 6PL F 4 .   ? 150.484 156.737 134.939 0.60 55.79  ? 801 6PL A C17 1 
HETATM 5874 C C16 . 6PL F 4 .   ? 150.075 155.393 135.529 0.60 55.46  ? 801 6PL A C16 1 
HETATM 5875 C C15 . 6PL F 4 .   ? 149.765 154.347 134.468 0.60 55.86  ? 801 6PL A C15 1 
HETATM 5876 C C14 . 6PL F 4 .   ? 148.616 154.742 133.549 0.60 54.71  ? 801 6PL A C14 1 
HETATM 5877 C C13 . 6PL F 4 .   ? 148.737 154.139 132.154 0.60 54.13  ? 801 6PL A C13 1 
HETATM 5878 C C12 . 6PL F 4 .   ? 150.071 154.488 131.517 0.60 54.23  ? 801 6PL A C12 1 
HETATM 5879 C C11 . 6PL F 4 .   ? 150.153 154.184 130.050 0.60 53.26  ? 801 6PL A C11 1 
HETATM 5880 O O11 . 6PL F 4 .   ? 149.258 153.734 129.379 0.60 53.32  ? 801 6PL A O11 1 
HETATM 5881 O O3  . 6PL F 4 .   ? 151.352 154.473 129.564 0.60 52.67  ? 801 6PL A O3  1 
HETATM 5882 C C3  . 6PL F 4 .   ? 151.454 155.531 128.620 0.60 50.78  ? 801 6PL A C3  1 
HETATM 5883 C C2  . 6PL F 4 .   ? 151.656 154.959 127.237 0.60 50.32  ? 801 6PL A C2  1 
HETATM 5884 C C1  . 6PL F 4 .   ? 153.027 155.214 126.627 0.60 50.33  ? 801 6PL A C1  1 
HETATM 5885 O O3P . 6PL F 4 .   ? 154.001 154.392 127.229 0.60 50.43  ? 801 6PL A O3P 1 
HETATM 5886 P P   . 6PL F 4 .   ? 154.932 153.433 126.298 0.60 45.08  ? 801 6PL A P   1 
HETATM 5887 O O1P . 6PL F 4 .   ? 154.428 152.019 126.296 0.60 55.12  ? 801 6PL A O1P 1 
HETATM 5888 O O2P . 6PL F 4 .   ? 155.238 154.114 125.003 0.60 50.50  ? 801 6PL A O2P 1 
HETATM 5889 O O4P . 6PL F 4 .   ? 156.227 153.526 127.312 0.60 50.13  ? 801 6PL A O4P 1 
HETATM 5890 C C4  . 6PL F 4 .   ? 156.858 154.767 127.503 0.60 53.44  ? 801 6PL A C4  1 
HETATM 5891 C C5  . 6PL F 4 .   ? 157.160 155.044 128.957 0.60 50.99  ? 801 6PL A C5  1 
HETATM 5892 N N   . 6PL F 4 .   ? 158.328 154.315 129.568 0.60 49.54  ? 801 6PL A N   1 
HETATM 5893 C C7  . 6PL F 4 .   ? 159.477 154.245 128.626 0.60 51.84  ? 801 6PL A C7  1 
HETATM 5894 C C8  . 6PL F 4 .   ? 158.744 155.092 130.768 0.60 52.13  ? 801 6PL A C8  1 
HETATM 5895 C C6  . 6PL F 4 .   ? 157.960 152.937 130.006 0.60 52.13  ? 801 6PL A C6  1 
HETATM 5896 O O2  . 6PL F 4 .   ? 150.585 155.419 126.400 0.60 55.29  ? 801 6PL A O2  1 
HETATM 5897 C C31 . 6PL F 4 .   ? 150.234 156.703 126.382 0.60 55.59  ? 801 6PL A C31 1 
HETATM 5898 O O31 . 6PL F 4 .   ? 151.008 157.609 126.203 0.60 57.69  ? 801 6PL A O31 1 
HETATM 5899 C C32 . 6PL F 4 .   ? 148.755 156.874 126.600 0.60 53.56  ? 801 6PL A C32 1 
HETATM 5900 C C33 . 6PL F 4 .   ? 148.309 158.327 126.610 0.60 53.69  ? 801 6PL A C33 1 
HETATM 5901 C C34 . 6PL F 4 .   ? 146.837 158.480 126.974 0.60 54.38  ? 801 6PL A C34 1 
HETATM 5902 C C35 . 6PL F 4 .   ? 146.481 159.905 127.377 0.60 55.52  ? 801 6PL A C35 1 
HETATM 5903 C C36 . 6PL F 4 .   ? 145.089 160.043 127.982 0.60 55.36  ? 801 6PL A C36 1 
HETATM 5904 C C37 . 6PL F 4 .   ? 144.908 161.346 128.753 0.60 53.68  ? 801 6PL A C37 1 
HETATM 5905 C C38 . 6PL F 4 .   ? 144.544 162.544 127.884 0.60 56.65  ? 801 6PL A C38 1 
HETATM 5906 C C39 . 6PL F 4 .   ? 143.086 162.527 127.440 0.60 55.87  ? 801 6PL A C39 1 
HETATM 5907 C C40 . 6PL F 4 .   ? 142.649 163.797 126.718 0.60 55.37  ? 801 6PL A C40 1 
HETATM 5908 C C41 . 6PL F 4 .   ? 141.194 163.756 126.267 0.60 53.84  ? 801 6PL A C41 1 
HETATM 5909 C C42 . 6PL F 4 .   ? 140.795 164.945 125.400 0.60 53.57  ? 801 6PL A C42 1 
HETATM 5910 C C43 . 6PL F 4 .   ? 141.680 165.099 124.170 0.60 53.77  ? 801 6PL A C43 1 
HETATM 5911 C C44 . 6PL F 4 .   ? 141.400 166.362 123.363 0.60 55.08  ? 801 6PL A C44 1 
HETATM 5912 C C45 . 6PL F 4 .   ? 140.018 166.369 122.720 0.60 54.28  ? 801 6PL A C45 1 
HETATM 5913 C C46 . 6PL F 4 .   ? 139.746 167.614 121.886 0.60 52.05  ? 801 6PL A C46 1 
HETATM 5914 C C26 . 6PL G 4 .   ? 154.559 109.244 145.510 0.60 66.82  ? 802 6PL A C26 1 
HETATM 5915 C C25 . 6PL G 4 .   ? 153.143 109.539 145.987 0.60 67.22  ? 802 6PL A C25 1 
HETATM 5916 C C24 . 6PL G 4 .   ? 152.723 110.983 145.738 0.60 67.46  ? 802 6PL A C24 1 
HETATM 5917 C C23 . 6PL G 4 .   ? 152.697 111.359 144.262 0.60 66.96  ? 802 6PL A C23 1 
HETATM 5918 C C22 . 6PL G 4 .   ? 152.406 112.836 144.021 0.60 66.65  ? 802 6PL A C22 1 
HETATM 5919 C C21 . 6PL G 4 .   ? 152.461 113.228 142.549 0.60 66.45  ? 802 6PL A C21 1 
HETATM 5920 C C20 . 6PL G 4 .   ? 152.438 114.735 142.321 0.60 67.72  ? 802 6PL A C20 1 
HETATM 5921 C C19 . 6PL G 4 .   ? 151.083 115.374 142.603 0.60 68.63  ? 802 6PL A C19 1 
HETATM 5922 C C18 . 6PL G 4 .   ? 151.064 116.877 142.346 0.60 68.08  ? 802 6PL A C18 1 
HETATM 5923 C C17 . 6PL G 4 .   ? 149.674 117.492 142.462 0.60 67.62  ? 802 6PL A C17 1 
HETATM 5924 C C16 . 6PL G 4 .   ? 149.660 119.002 142.257 0.60 67.97  ? 802 6PL A C16 1 
HETATM 5925 C C15 . 6PL G 4 .   ? 148.252 119.579 142.177 0.60 66.67  ? 802 6PL A C15 1 
HETATM 5926 C C14 . 6PL G 4 .   ? 148.223 121.095 142.023 0.60 67.23  ? 802 6PL A C14 1 
HETATM 5927 C C13 . 6PL G 4 .   ? 148.460 121.837 143.334 0.60 67.41  ? 802 6PL A C13 1 
HETATM 5928 C C12 . 6PL G 4 .   ? 148.293 123.338 143.168 0.60 67.59  ? 802 6PL A C12 1 
HETATM 5929 C C11 . 6PL G 4 .   ? 148.304 124.105 144.459 0.60 68.18  ? 802 6PL A C11 1 
HETATM 5930 O O11 . 6PL G 4 .   ? 148.307 123.617 145.562 0.60 67.45  ? 802 6PL A O11 1 
HETATM 5931 O O3  . 6PL G 4 .   ? 148.313 125.414 144.237 0.60 68.40  ? 802 6PL A O3  1 
HETATM 5932 C C3  . 6PL G 4 .   ? 147.593 126.270 145.116 0.60 67.58  ? 802 6PL A C3  1 
HETATM 5933 C C2  . 6PL G 4 .   ? 148.497 126.800 146.210 0.60 68.13  ? 802 6PL A C2  1 
HETATM 5934 C C1  . 6PL G 4 .   ? 147.849 127.810 147.147 0.60 66.72  ? 802 6PL A C1  1 
HETATM 5935 O O3P . 6PL G 4 .   ? 147.019 127.161 148.083 0.60 66.72  ? 802 6PL A O3P 1 
HETATM 5936 P P   . 6PL G 4 .   ? 146.167 128.041 149.160 0.60 66.87  ? 802 6PL A P   1 
HETATM 5937 O O1P . 6PL G 4 .   ? 146.029 129.465 148.706 0.60 68.43  ? 802 6PL A O1P 1 
HETATM 5938 O O2P . 6PL G 4 .   ? 144.957 127.284 149.608 0.60 64.35  ? 802 6PL A O2P 1 
HETATM 5939 O O4P . 6PL G 4 .   ? 147.351 127.960 150.305 0.60 65.84  ? 802 6PL A O4P 1 
HETATM 5940 C C4  . 6PL G 4 .   ? 147.001 127.855 151.663 0.60 65.35  ? 802 6PL A C4  1 
HETATM 5941 C C5  . 6PL G 4 .   ? 148.154 128.202 152.578 0.60 66.73  ? 802 6PL A C5  1 
HETATM 5942 N N   . 6PL G 4 .   ? 148.334 129.648 152.963 0.60 64.05  ? 802 6PL A N   1 
HETATM 5943 C C7  . 6PL G 4 .   ? 147.086 130.208 153.548 0.60 64.13  ? 802 6PL A C7  1 
HETATM 5944 C C8  . 6PL G 4 .   ? 149.410 129.694 153.992 0.60 64.35  ? 802 6PL A C8  1 
HETATM 5945 C C6  . 6PL G 4 .   ? 148.760 130.492 151.809 0.60 64.80  ? 802 6PL A C6  1 
HETATM 5946 O O2  . 6PL G 4 .   ? 149.703 127.301 145.614 0.60 67.79  ? 802 6PL A O2  1 
HETATM 5947 C C31 . 6PL G 4 .   ? 149.669 128.101 144.548 0.60 68.67  ? 802 6PL A C31 1 
HETATM 5948 O O31 . 6PL G 4 .   ? 148.998 129.101 144.474 0.60 68.49  ? 802 6PL A O31 1 
HETATM 5949 C C32 . 6PL G 4 .   ? 150.580 127.591 143.462 0.60 67.22  ? 802 6PL A C32 1 
HETATM 5950 C C33 . 6PL G 4 .   ? 150.856 128.601 142.360 0.60 66.21  ? 802 6PL A C33 1 
HETATM 5951 C C34 . 6PL G 4 .   ? 151.863 128.074 141.345 0.60 66.21  ? 802 6PL A C34 1 
HETATM 5952 C C35 . 6PL G 4 .   ? 152.589 129.190 140.605 0.60 67.41  ? 802 6PL A C35 1 
HETATM 5953 C C36 . 6PL G 4 .   ? 151.885 129.667 139.340 0.60 67.54  ? 802 6PL A C36 1 
HETATM 5954 C C37 . 6PL G 4 .   ? 152.705 130.699 138.576 0.60 67.59  ? 802 6PL A C37 1 
HETATM 5955 C C38 . 6PL G 4 .   ? 152.845 132.033 139.299 0.60 67.30  ? 802 6PL A C38 1 
HETATM 5956 C C39 . 6PL G 4 .   ? 153.996 132.879 138.768 0.60 68.41  ? 802 6PL A C39 1 
HETATM 5957 C C40 . 6PL G 4 .   ? 154.048 134.282 139.361 0.60 66.36  ? 802 6PL A C40 1 
HETATM 5958 C C41 . 6PL G 4 .   ? 155.387 134.977 139.143 0.60 66.41  ? 802 6PL A C41 1 
HETATM 5959 C C42 . 6PL G 4 .   ? 155.745 135.192 137.677 0.60 65.22  ? 802 6PL A C42 1 
HETATM 5960 C C43 . 6PL G 4 .   ? 156.992 136.049 137.494 0.60 65.48  ? 802 6PL A C43 1 
HETATM 5961 C C44 . 6PL G 4 .   ? 157.391 136.252 136.038 0.60 68.05  ? 802 6PL A C44 1 
HETATM 5962 C C45 . 6PL G 4 .   ? 157.811 134.961 135.346 0.60 68.90  ? 802 6PL A C45 1 
HETATM 5963 C C46 . 6PL G 4 .   ? 158.266 135.163 133.907 0.60 65.13  ? 802 6PL A C46 1 
HETATM 5964 C C1  . NAG H 5 .   ? 102.670 120.530 162.787 1.00 101.76 ? 803 NAG A C1  1 
HETATM 5965 C C2  . NAG H 5 .   ? 101.934 119.714 161.727 1.00 102.68 ? 803 NAG A C2  1 
HETATM 5966 C C3  . NAG H 5 .   ? 102.926 118.966 160.830 1.00 101.08 ? 803 NAG A C3  1 
HETATM 5967 C C4  . NAG H 5 .   ? 104.062 118.348 161.639 1.00 102.50 ? 803 NAG A C4  1 
HETATM 5968 C C5  . NAG H 5 .   ? 104.710 119.375 162.563 1.00 101.14 ? 803 NAG A C5  1 
HETATM 5969 C C6  . NAG H 5 .   ? 106.162 119.633 162.235 1.00 98.63  ? 803 NAG A C6  1 
HETATM 5970 C C7  . NAG H 5 .   ? 99.754  119.125 162.691 1.00 100.92 ? 803 NAG A C7  1 
HETATM 5971 C C8  . NAG H 5 .   ? 98.927  118.041 163.312 1.00 98.45  ? 803 NAG A C8  1 
HETATM 5972 N N2  . NAG H 5 .   ? 100.999 118.785 162.341 1.00 102.26 ? 803 NAG A N2  1 
HETATM 5973 O O3  . NAG H 5 .   ? 103.454 119.863 159.859 1.00 97.47  ? 803 NAG A O3  1 
HETATM 5974 O O4  . NAG H 5 .   ? 103.568 117.264 162.418 1.00 101.06 ? 803 NAG A O4  1 
HETATM 5975 O O5  . NAG H 5 .   ? 104.031 120.631 162.444 1.00 102.36 ? 803 NAG A O5  1 
HETATM 5976 O O6  . NAG H 5 .   ? 106.396 121.008 161.963 1.00 97.93  ? 803 NAG A O6  1 
HETATM 5977 O O7  . NAG H 5 .   ? 99.315  120.257 162.513 1.00 99.59  ? 803 NAG A O7  1 
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