data_9BV6
# 
_entry.id   9BV6 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BV6         pdb_00009bv6 10.2210/pdb9bv6/pdb 
WWPDB D_1000284179 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-04-16 ? 
2 'Structure model' 1 1 2025-04-23 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
5 2 'Structure model' '_citation.title'                   
6 2 'Structure model' '_citation_author.name'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BV6 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-20 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              taosheng.chen@stjude.org 
_pdbx_contact_author.name_first         Taosheng 
_pdbx_contact_author.name_last          Chen 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-6420-3809 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Jingheng, W.'      1 0000-0001-5747-6673 
'Nithianantham, S.' 2 0000-0001-6238-647X 
'Miller, D.J.'      3 0000-0003-1202-511X 
'Chen, T.'          4 0000-0001-6420-3809 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            16 
_citation.language                  ? 
_citation.page_first                3423 
_citation.page_last                 3423 
_citation.title                     'Decoding the selective chemical modulation of CYP3A4.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-025-58749-8 
_citation.pdbx_database_id_PubMed   40210880 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Wang, J.'          1  ? 
primary 'Nithianantham, S.' 2  ? 
primary 'Chai, S.C.'        3  ? 
primary 'Jung, Y.H.'        4  ? 
primary 'Yang, L.'          5  ? 
primary 'Ong, H.W.'         6  ? 
primary 'Li, Y.'            7  ? 
primary 'Zhang, Y.'         8  ? 
primary 'Miller, D.J.'      9  ? 
primary 'Chen, T.'          10 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Cytochrome P450 3A4'                                                           55594.637 1 
1.14.14.1,1.14.14.56,1.14.14.73,1.14.14.55 ? ? ? 
2 non-polymer syn 'PROTOPORPHYRIN IX CONTAINING FE'                                               616.487   1 ? ? ? ? 
3 non-polymer syn '5-(4-methoxyphenyl)-1-[4-(2-methyl-1,3-thiazol-4-yl)phenyl]-1H-1,2,3-triazole' 348.422   1 ? ? ? ? 
4 non-polymer nat '2-(2-METHOXYETHOXY)ETHANOL'                                                    120.147   1 ? ? ? ? 
5 water       nat water                                                                           18.015    1 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
;1,4-cineole 2-exo-monooxygenase,8-cineole 2-exo-monooxygenase,Albendazole monooxygenase (sulfoxide-forming),Albendazole sulfoxidase,CYPIIIA3,CYPIIIA4,Cholesterol 25-hydroxylase,Cytochrome P450 3A3,Cytochrome P450 HLp,Cytochrome P450 NF-25,Cytochrome P450-PCN1,Nifedipine oxidase,Quinine 3-monooxygenase
;
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MALYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSV
FTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSM
DVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRL
EDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN
KAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK
KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTVS
GAHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MALYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSV
FTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSM
DVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRL
EDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN
KAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK
KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTVS
GAHHHH
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'PROTOPORPHYRIN IX CONTAINING FE'                                               HEM   
3 '5-(4-methoxyphenyl)-1-[4-(2-methyl-1,3-thiazol-4-yl)phenyl]-1H-1,2,3-triazole' A1ASU 
4 '2-(2-METHOXYETHOXY)ETHANOL'                                                    PG0   
5 water                                                                           HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   LEU n 
1 4   TYR n 
1 5   GLY n 
1 6   THR n 
1 7   HIS n 
1 8   SER n 
1 9   HIS n 
1 10  GLY n 
1 11  LEU n 
1 12  PHE n 
1 13  LYS n 
1 14  LYS n 
1 15  LEU n 
1 16  GLY n 
1 17  ILE n 
1 18  PRO n 
1 19  GLY n 
1 20  PRO n 
1 21  THR n 
1 22  PRO n 
1 23  LEU n 
1 24  PRO n 
1 25  PHE n 
1 26  LEU n 
1 27  GLY n 
1 28  ASN n 
1 29  ILE n 
1 30  LEU n 
1 31  SER n 
1 32  TYR n 
1 33  HIS n 
1 34  LYS n 
1 35  GLY n 
1 36  PHE n 
1 37  CYS n 
1 38  MET n 
1 39  PHE n 
1 40  ASP n 
1 41  MET n 
1 42  GLU n 
1 43  CYS n 
1 44  HIS n 
1 45  LYS n 
1 46  LYS n 
1 47  TYR n 
1 48  GLY n 
1 49  LYS n 
1 50  VAL n 
1 51  TRP n 
1 52  GLY n 
1 53  PHE n 
1 54  TYR n 
1 55  ASP n 
1 56  GLY n 
1 57  GLN n 
1 58  GLN n 
1 59  PRO n 
1 60  VAL n 
1 61  LEU n 
1 62  ALA n 
1 63  ILE n 
1 64  THR n 
1 65  ASP n 
1 66  PRO n 
1 67  ASP n 
1 68  MET n 
1 69  ILE n 
1 70  LYS n 
1 71  THR n 
1 72  VAL n 
1 73  LEU n 
1 74  VAL n 
1 75  LYS n 
1 76  GLU n 
1 77  CYS n 
1 78  TYR n 
1 79  SER n 
1 80  VAL n 
1 81  PHE n 
1 82  THR n 
1 83  ASN n 
1 84  ARG n 
1 85  ARG n 
1 86  PRO n 
1 87  PHE n 
1 88  GLY n 
1 89  PRO n 
1 90  VAL n 
1 91  GLY n 
1 92  PHE n 
1 93  MET n 
1 94  LYS n 
1 95  SER n 
1 96  ALA n 
1 97  ILE n 
1 98  SER n 
1 99  ILE n 
1 100 ALA n 
1 101 GLU n 
1 102 ASP n 
1 103 GLU n 
1 104 GLU n 
1 105 TRP n 
1 106 LYS n 
1 107 ARG n 
1 108 LEU n 
1 109 ARG n 
1 110 SER n 
1 111 LEU n 
1 112 LEU n 
1 113 SER n 
1 114 PRO n 
1 115 THR n 
1 116 PHE n 
1 117 THR n 
1 118 SER n 
1 119 GLY n 
1 120 LYS n 
1 121 LEU n 
1 122 LYS n 
1 123 GLU n 
1 124 MET n 
1 125 VAL n 
1 126 PRO n 
1 127 ILE n 
1 128 ILE n 
1 129 ALA n 
1 130 GLN n 
1 131 TYR n 
1 132 GLY n 
1 133 ASP n 
1 134 VAL n 
1 135 LEU n 
1 136 VAL n 
1 137 ARG n 
1 138 ASN n 
1 139 LEU n 
1 140 ARG n 
1 141 ARG n 
1 142 GLU n 
1 143 ALA n 
1 144 GLU n 
1 145 THR n 
1 146 GLY n 
1 147 LYS n 
1 148 PRO n 
1 149 VAL n 
1 150 THR n 
1 151 LEU n 
1 152 LYS n 
1 153 ASP n 
1 154 VAL n 
1 155 PHE n 
1 156 GLY n 
1 157 ALA n 
1 158 TYR n 
1 159 SER n 
1 160 MET n 
1 161 ASP n 
1 162 VAL n 
1 163 ILE n 
1 164 THR n 
1 165 SER n 
1 166 THR n 
1 167 SER n 
1 168 PHE n 
1 169 GLY n 
1 170 VAL n 
1 171 ASN n 
1 172 ILE n 
1 173 ASP n 
1 174 SER n 
1 175 LEU n 
1 176 ASN n 
1 177 ASN n 
1 178 PRO n 
1 179 GLN n 
1 180 ASP n 
1 181 PRO n 
1 182 PHE n 
1 183 VAL n 
1 184 GLU n 
1 185 ASN n 
1 186 THR n 
1 187 LYS n 
1 188 LYS n 
1 189 LEU n 
1 190 LEU n 
1 191 ARG n 
1 192 PHE n 
1 193 ASP n 
1 194 PHE n 
1 195 LEU n 
1 196 ASP n 
1 197 PRO n 
1 198 PHE n 
1 199 PHE n 
1 200 LEU n 
1 201 SER n 
1 202 ILE n 
1 203 THR n 
1 204 VAL n 
1 205 PHE n 
1 206 PRO n 
1 207 PHE n 
1 208 LEU n 
1 209 ILE n 
1 210 PRO n 
1 211 ILE n 
1 212 LEU n 
1 213 GLU n 
1 214 VAL n 
1 215 LEU n 
1 216 ASN n 
1 217 ILE n 
1 218 CYS n 
1 219 VAL n 
1 220 PHE n 
1 221 PRO n 
1 222 ARG n 
1 223 GLU n 
1 224 VAL n 
1 225 THR n 
1 226 ASN n 
1 227 PHE n 
1 228 LEU n 
1 229 ARG n 
1 230 LYS n 
1 231 SER n 
1 232 VAL n 
1 233 LYS n 
1 234 ARG n 
1 235 MET n 
1 236 LYS n 
1 237 GLU n 
1 238 SER n 
1 239 ARG n 
1 240 LEU n 
1 241 GLU n 
1 242 ASP n 
1 243 THR n 
1 244 GLN n 
1 245 LYS n 
1 246 HIS n 
1 247 ARG n 
1 248 VAL n 
1 249 ASP n 
1 250 PHE n 
1 251 LEU n 
1 252 GLN n 
1 253 LEU n 
1 254 MET n 
1 255 ILE n 
1 256 ASP n 
1 257 SER n 
1 258 GLN n 
1 259 ASN n 
1 260 SER n 
1 261 LYS n 
1 262 GLU n 
1 263 THR n 
1 264 GLU n 
1 265 SER n 
1 266 HIS n 
1 267 LYS n 
1 268 ALA n 
1 269 LEU n 
1 270 SER n 
1 271 ASP n 
1 272 LEU n 
1 273 GLU n 
1 274 LEU n 
1 275 VAL n 
1 276 ALA n 
1 277 GLN n 
1 278 SER n 
1 279 ILE n 
1 280 ILE n 
1 281 PHE n 
1 282 ILE n 
1 283 PHE n 
1 284 ALA n 
1 285 GLY n 
1 286 TYR n 
1 287 GLU n 
1 288 THR n 
1 289 THR n 
1 290 SER n 
1 291 SER n 
1 292 VAL n 
1 293 LEU n 
1 294 SER n 
1 295 PHE n 
1 296 ILE n 
1 297 MET n 
1 298 TYR n 
1 299 GLU n 
1 300 LEU n 
1 301 ALA n 
1 302 THR n 
1 303 HIS n 
1 304 PRO n 
1 305 ASP n 
1 306 VAL n 
1 307 GLN n 
1 308 GLN n 
1 309 LYS n 
1 310 LEU n 
1 311 GLN n 
1 312 GLU n 
1 313 GLU n 
1 314 ILE n 
1 315 ASP n 
1 316 ALA n 
1 317 VAL n 
1 318 LEU n 
1 319 PRO n 
1 320 ASN n 
1 321 LYS n 
1 322 ALA n 
1 323 PRO n 
1 324 PRO n 
1 325 THR n 
1 326 TYR n 
1 327 ASP n 
1 328 THR n 
1 329 VAL n 
1 330 LEU n 
1 331 GLN n 
1 332 MET n 
1 333 GLU n 
1 334 TYR n 
1 335 LEU n 
1 336 ASP n 
1 337 MET n 
1 338 VAL n 
1 339 VAL n 
1 340 ASN n 
1 341 GLU n 
1 342 THR n 
1 343 LEU n 
1 344 ARG n 
1 345 LEU n 
1 346 PHE n 
1 347 PRO n 
1 348 ILE n 
1 349 ALA n 
1 350 MET n 
1 351 ARG n 
1 352 LEU n 
1 353 GLU n 
1 354 ARG n 
1 355 VAL n 
1 356 CYS n 
1 357 LYS n 
1 358 LYS n 
1 359 ASP n 
1 360 VAL n 
1 361 GLU n 
1 362 ILE n 
1 363 ASN n 
1 364 GLY n 
1 365 MET n 
1 366 PHE n 
1 367 ILE n 
1 368 PRO n 
1 369 LYS n 
1 370 GLY n 
1 371 VAL n 
1 372 VAL n 
1 373 VAL n 
1 374 MET n 
1 375 ILE n 
1 376 PRO n 
1 377 SER n 
1 378 TYR n 
1 379 ALA n 
1 380 LEU n 
1 381 HIS n 
1 382 ARG n 
1 383 ASP n 
1 384 PRO n 
1 385 LYS n 
1 386 TYR n 
1 387 TRP n 
1 388 THR n 
1 389 GLU n 
1 390 PRO n 
1 391 GLU n 
1 392 LYS n 
1 393 PHE n 
1 394 LEU n 
1 395 PRO n 
1 396 GLU n 
1 397 ARG n 
1 398 PHE n 
1 399 SER n 
1 400 LYS n 
1 401 LYS n 
1 402 ASN n 
1 403 LYS n 
1 404 ASP n 
1 405 ASN n 
1 406 ILE n 
1 407 ASP n 
1 408 PRO n 
1 409 TYR n 
1 410 ILE n 
1 411 TYR n 
1 412 THR n 
1 413 PRO n 
1 414 PHE n 
1 415 GLY n 
1 416 SER n 
1 417 GLY n 
1 418 PRO n 
1 419 ARG n 
1 420 ASN n 
1 421 CYS n 
1 422 ILE n 
1 423 GLY n 
1 424 MET n 
1 425 ARG n 
1 426 PHE n 
1 427 ALA n 
1 428 LEU n 
1 429 MET n 
1 430 ASN n 
1 431 MET n 
1 432 LYS n 
1 433 LEU n 
1 434 ALA n 
1 435 LEU n 
1 436 ILE n 
1 437 ARG n 
1 438 VAL n 
1 439 LEU n 
1 440 GLN n 
1 441 ASN n 
1 442 PHE n 
1 443 SER n 
1 444 PHE n 
1 445 LYS n 
1 446 PRO n 
1 447 CYS n 
1 448 LYS n 
1 449 GLU n 
1 450 THR n 
1 451 GLN n 
1 452 ILE n 
1 453 PRO n 
1 454 LEU n 
1 455 LYS n 
1 456 LEU n 
1 457 SER n 
1 458 LEU n 
1 459 GLY n 
1 460 GLY n 
1 461 LEU n 
1 462 LEU n 
1 463 GLN n 
1 464 PRO n 
1 465 GLU n 
1 466 LYS n 
1 467 PRO n 
1 468 VAL n 
1 469 VAL n 
1 470 LEU n 
1 471 LYS n 
1 472 VAL n 
1 473 GLU n 
1 474 SER n 
1 475 ARG n 
1 476 ASP n 
1 477 GLY n 
1 478 THR n 
1 479 VAL n 
1 480 SER n 
1 481 GLY n 
1 482 ALA n 
1 483 HIS n 
1 484 HIS n 
1 485 HIS n 
1 486 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   486 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'CYP3A4, CYP3A3' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               DH5alpha 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          PLASMID 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       pCWori 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1ASU non-polymer         . '5-(4-methoxyphenyl)-1-[4-(2-methyl-1,3-thiazol-4-yl)phenyl]-1H-1,2,3-triazole' ?          
'C19 H16 N4 O S'   348.422 
ALA   'L-peptide linking' y ALANINE                                                                         ?          
'C3 H7 N O2'       89.093  
ARG   'L-peptide linking' y ARGININE                                                                        ?          
'C6 H15 N4 O2 1'   175.209 
ASN   'L-peptide linking' y ASPARAGINE                                                                      ?          
'C4 H8 N2 O3'      132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID'                                                                 ?          
'C4 H7 N O4'       133.103 
CYS   'L-peptide linking' y CYSTEINE                                                                        ?          
'C3 H7 N O2 S'     121.158 
GLN   'L-peptide linking' y GLUTAMINE                                                                       ?          
'C5 H10 N2 O3'     146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID'                                                                 ?          
'C5 H9 N O4'       147.129 
GLY   'peptide linking'   y GLYCINE                                                                         ?          
'C2 H5 N O2'       75.067  
HEM   non-polymer         . 'PROTOPORPHYRIN IX CONTAINING FE'                                               HEME       
'C34 H32 Fe N4 O4' 616.487 
HIS   'L-peptide linking' y HISTIDINE                                                                       ?          
'C6 H10 N3 O2 1'   156.162 
HOH   non-polymer         . WATER                                                                           ?          'H2 O' 
18.015  
ILE   'L-peptide linking' y ISOLEUCINE                                                                      ?          
'C6 H13 N O2'      131.173 
LEU   'L-peptide linking' y LEUCINE                                                                         ?          
'C6 H13 N O2'      131.173 
LYS   'L-peptide linking' y LYSINE                                                                          ?          
'C6 H15 N2 O2 1'   147.195 
MET   'L-peptide linking' y METHIONINE                                                                      ?          
'C5 H11 N O2 S'    149.211 
PG0   non-polymer         . '2-(2-METHOXYETHOXY)ETHANOL'                                                    'PEG 6000' 'C5 H12 O3' 
120.147 
PHE   'L-peptide linking' y PHENYLALANINE                                                                   ?          
'C9 H11 N O2'      165.189 
PRO   'L-peptide linking' y PROLINE                                                                         ?          
'C5 H9 N O2'       115.130 
SER   'L-peptide linking' y SERINE                                                                          ?          
'C3 H7 N O3'       105.093 
THR   'L-peptide linking' y THREONINE                                                                       ?          
'C4 H9 N O3'       119.119 
TRP   'L-peptide linking' y TRYPTOPHAN                                                                      ?          
'C11 H12 N2 O2'    204.225 
TYR   'L-peptide linking' y TYROSINE                                                                        ?          
'C9 H11 N O3'      181.189 
VAL   'L-peptide linking' y VALINE                                                                          ?          
'C5 H11 N O2'      117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   22  ?   ?   ?   A . n 
A 1 2   ALA 2   23  ?   ?   ?   A . n 
A 1 3   LEU 3   24  ?   ?   ?   A . n 
A 1 4   TYR 4   25  ?   ?   ?   A . n 
A 1 5   GLY 5   26  ?   ?   ?   A . n 
A 1 6   THR 6   27  ?   ?   ?   A . n 
A 1 7   HIS 7   28  ?   ?   ?   A . n 
A 1 8   SER 8   29  29  SER SER A . n 
A 1 9   HIS 9   30  30  HIS HIS A . n 
A 1 10  GLY 10  31  31  GLY GLY A . n 
A 1 11  LEU 11  32  32  LEU LEU A . n 
A 1 12  PHE 12  33  33  PHE PHE A . n 
A 1 13  LYS 13  34  34  LYS LYS A . n 
A 1 14  LYS 14  35  35  LYS LYS A . n 
A 1 15  LEU 15  36  36  LEU LEU A . n 
A 1 16  GLY 16  37  37  GLY GLY A . n 
A 1 17  ILE 17  38  38  ILE ILE A . n 
A 1 18  PRO 18  39  39  PRO PRO A . n 
A 1 19  GLY 19  40  40  GLY GLY A . n 
A 1 20  PRO 20  41  41  PRO PRO A . n 
A 1 21  THR 21  42  42  THR THR A . n 
A 1 22  PRO 22  43  43  PRO PRO A . n 
A 1 23  LEU 23  44  44  LEU LEU A . n 
A 1 24  PRO 24  45  45  PRO PRO A . n 
A 1 25  PHE 25  46  46  PHE PHE A . n 
A 1 26  LEU 26  47  47  LEU LEU A . n 
A 1 27  GLY 27  48  48  GLY GLY A . n 
A 1 28  ASN 28  49  49  ASN ASN A . n 
A 1 29  ILE 29  50  50  ILE ILE A . n 
A 1 30  LEU 30  51  51  LEU LEU A . n 
A 1 31  SER 31  52  52  SER SER A . n 
A 1 32  TYR 32  53  53  TYR TYR A . n 
A 1 33  HIS 33  54  54  HIS HIS A . n 
A 1 34  LYS 34  55  55  LYS LYS A . n 
A 1 35  GLY 35  56  56  GLY GLY A . n 
A 1 36  PHE 36  57  57  PHE PHE A . n 
A 1 37  CYS 37  58  58  CYS CYS A . n 
A 1 38  MET 38  59  59  MET MET A . n 
A 1 39  PHE 39  60  60  PHE PHE A . n 
A 1 40  ASP 40  61  61  ASP ASP A . n 
A 1 41  MET 41  62  62  MET MET A . n 
A 1 42  GLU 42  63  63  GLU GLU A . n 
A 1 43  CYS 43  64  64  CYS CYS A . n 
A 1 44  HIS 44  65  65  HIS HIS A . n 
A 1 45  LYS 45  66  66  LYS LYS A . n 
A 1 46  LYS 46  67  67  LYS LYS A . n 
A 1 47  TYR 47  68  68  TYR TYR A . n 
A 1 48  GLY 48  69  69  GLY GLY A . n 
A 1 49  LYS 49  70  70  LYS LYS A . n 
A 1 50  VAL 50  71  71  VAL VAL A . n 
A 1 51  TRP 51  72  72  TRP TRP A . n 
A 1 52  GLY 52  73  73  GLY GLY A . n 
A 1 53  PHE 53  74  74  PHE PHE A . n 
A 1 54  TYR 54  75  75  TYR TYR A . n 
A 1 55  ASP 55  76  76  ASP ASP A . n 
A 1 56  GLY 56  77  77  GLY GLY A . n 
A 1 57  GLN 57  78  78  GLN GLN A . n 
A 1 58  GLN 58  79  79  GLN GLN A . n 
A 1 59  PRO 59  80  80  PRO PRO A . n 
A 1 60  VAL 60  81  81  VAL VAL A . n 
A 1 61  LEU 61  82  82  LEU LEU A . n 
A 1 62  ALA 62  83  83  ALA ALA A . n 
A 1 63  ILE 63  84  84  ILE ILE A . n 
A 1 64  THR 64  85  85  THR THR A . n 
A 1 65  ASP 65  86  86  ASP ASP A . n 
A 1 66  PRO 66  87  87  PRO PRO A . n 
A 1 67  ASP 67  88  88  ASP ASP A . n 
A 1 68  MET 68  89  89  MET MET A . n 
A 1 69  ILE 69  90  90  ILE ILE A . n 
A 1 70  LYS 70  91  91  LYS LYS A . n 
A 1 71  THR 71  92  92  THR THR A . n 
A 1 72  VAL 72  93  93  VAL VAL A . n 
A 1 73  LEU 73  94  94  LEU LEU A . n 
A 1 74  VAL 74  95  95  VAL VAL A . n 
A 1 75  LYS 75  96  96  LYS LYS A . n 
A 1 76  GLU 76  97  97  GLU GLU A . n 
A 1 77  CYS 77  98  98  CYS CYS A . n 
A 1 78  TYR 78  99  99  TYR TYR A . n 
A 1 79  SER 79  100 100 SER SER A . n 
A 1 80  VAL 80  101 101 VAL VAL A . n 
A 1 81  PHE 81  102 102 PHE PHE A . n 
A 1 82  THR 82  103 103 THR THR A . n 
A 1 83  ASN 83  104 104 ASN ASN A . n 
A 1 84  ARG 84  105 105 ARG ARG A . n 
A 1 85  ARG 85  106 106 ARG ARG A . n 
A 1 86  PRO 86  107 107 PRO PRO A . n 
A 1 87  PHE 87  108 108 PHE PHE A . n 
A 1 88  GLY 88  109 109 GLY GLY A . n 
A 1 89  PRO 89  110 110 PRO PRO A . n 
A 1 90  VAL 90  111 111 VAL VAL A . n 
A 1 91  GLY 91  112 112 GLY GLY A . n 
A 1 92  PHE 92  113 113 PHE PHE A . n 
A 1 93  MET 93  114 114 MET MET A . n 
A 1 94  LYS 94  115 115 LYS LYS A . n 
A 1 95  SER 95  116 116 SER SER A . n 
A 1 96  ALA 96  117 117 ALA ALA A . n 
A 1 97  ILE 97  118 118 ILE ILE A . n 
A 1 98  SER 98  119 119 SER SER A . n 
A 1 99  ILE 99  120 120 ILE ILE A . n 
A 1 100 ALA 100 121 121 ALA ALA A . n 
A 1 101 GLU 101 122 122 GLU GLU A . n 
A 1 102 ASP 102 123 123 ASP ASP A . n 
A 1 103 GLU 103 124 124 GLU GLU A . n 
A 1 104 GLU 104 125 125 GLU GLU A . n 
A 1 105 TRP 105 126 126 TRP TRP A . n 
A 1 106 LYS 106 127 127 LYS LYS A . n 
A 1 107 ARG 107 128 128 ARG ARG A . n 
A 1 108 LEU 108 129 129 LEU LEU A . n 
A 1 109 ARG 109 130 130 ARG ARG A . n 
A 1 110 SER 110 131 131 SER SER A . n 
A 1 111 LEU 111 132 132 LEU LEU A . n 
A 1 112 LEU 112 133 133 LEU LEU A . n 
A 1 113 SER 113 134 134 SER SER A . n 
A 1 114 PRO 114 135 135 PRO PRO A . n 
A 1 115 THR 115 136 136 THR THR A . n 
A 1 116 PHE 116 137 137 PHE PHE A . n 
A 1 117 THR 117 138 138 THR THR A . n 
A 1 118 SER 118 139 139 SER SER A . n 
A 1 119 GLY 119 140 140 GLY GLY A . n 
A 1 120 LYS 120 141 141 LYS LYS A . n 
A 1 121 LEU 121 142 142 LEU LEU A . n 
A 1 122 LYS 122 143 143 LYS LYS A . n 
A 1 123 GLU 123 144 144 GLU GLU A . n 
A 1 124 MET 124 145 145 MET MET A . n 
A 1 125 VAL 125 146 146 VAL VAL A . n 
A 1 126 PRO 126 147 147 PRO PRO A . n 
A 1 127 ILE 127 148 148 ILE ILE A . n 
A 1 128 ILE 128 149 149 ILE ILE A . n 
A 1 129 ALA 129 150 150 ALA ALA A . n 
A 1 130 GLN 130 151 151 GLN GLN A . n 
A 1 131 TYR 131 152 152 TYR TYR A . n 
A 1 132 GLY 132 153 153 GLY GLY A . n 
A 1 133 ASP 133 154 154 ASP ASP A . n 
A 1 134 VAL 134 155 155 VAL VAL A . n 
A 1 135 LEU 135 156 156 LEU LEU A . n 
A 1 136 VAL 136 157 157 VAL VAL A . n 
A 1 137 ARG 137 158 158 ARG ARG A . n 
A 1 138 ASN 138 159 159 ASN ASN A . n 
A 1 139 LEU 139 160 160 LEU LEU A . n 
A 1 140 ARG 140 161 161 ARG ARG A . n 
A 1 141 ARG 141 162 162 ARG ARG A . n 
A 1 142 GLU 142 163 163 GLU GLU A . n 
A 1 143 ALA 143 164 164 ALA ALA A . n 
A 1 144 GLU 144 165 165 GLU GLU A . n 
A 1 145 THR 145 166 166 THR THR A . n 
A 1 146 GLY 146 167 167 GLY GLY A . n 
A 1 147 LYS 147 168 168 LYS LYS A . n 
A 1 148 PRO 148 169 169 PRO PRO A . n 
A 1 149 VAL 149 170 170 VAL VAL A . n 
A 1 150 THR 150 171 171 THR THR A . n 
A 1 151 LEU 151 172 172 LEU LEU A . n 
A 1 152 LYS 152 173 173 LYS LYS A . n 
A 1 153 ASP 153 174 174 ASP ASP A . n 
A 1 154 VAL 154 175 175 VAL VAL A . n 
A 1 155 PHE 155 176 176 PHE PHE A . n 
A 1 156 GLY 156 177 177 GLY GLY A . n 
A 1 157 ALA 157 178 178 ALA ALA A . n 
A 1 158 TYR 158 179 179 TYR TYR A . n 
A 1 159 SER 159 180 180 SER SER A . n 
A 1 160 MET 160 181 181 MET MET A . n 
A 1 161 ASP 161 182 182 ASP ASP A . n 
A 1 162 VAL 162 183 183 VAL VAL A . n 
A 1 163 ILE 163 184 184 ILE ILE A . n 
A 1 164 THR 164 185 185 THR THR A . n 
A 1 165 SER 165 186 186 SER SER A . n 
A 1 166 THR 166 187 187 THR THR A . n 
A 1 167 SER 167 188 188 SER SER A . n 
A 1 168 PHE 168 189 189 PHE PHE A . n 
A 1 169 GLY 169 190 190 GLY GLY A . n 
A 1 170 VAL 170 191 191 VAL VAL A . n 
A 1 171 ASN 171 192 192 ASN ASN A . n 
A 1 172 ILE 172 193 193 ILE ILE A . n 
A 1 173 ASP 173 194 194 ASP ASP A . n 
A 1 174 SER 174 195 195 SER SER A . n 
A 1 175 LEU 175 196 196 LEU LEU A . n 
A 1 176 ASN 176 197 197 ASN ASN A . n 
A 1 177 ASN 177 198 198 ASN ASN A . n 
A 1 178 PRO 178 199 199 PRO PRO A . n 
A 1 179 GLN 179 200 200 GLN GLN A . n 
A 1 180 ASP 180 201 201 ASP ASP A . n 
A 1 181 PRO 181 202 202 PRO PRO A . n 
A 1 182 PHE 182 203 203 PHE PHE A . n 
A 1 183 VAL 183 204 204 VAL VAL A . n 
A 1 184 GLU 184 205 205 GLU GLU A . n 
A 1 185 ASN 185 206 206 ASN ASN A . n 
A 1 186 THR 186 207 207 THR THR A . n 
A 1 187 LYS 187 208 208 LYS LYS A . n 
A 1 188 LYS 188 209 209 LYS LYS A . n 
A 1 189 LEU 189 210 210 LEU LEU A . n 
A 1 190 LEU 190 211 211 LEU LEU A . n 
A 1 191 ARG 191 212 212 ARG ARG A . n 
A 1 192 PHE 192 213 213 PHE PHE A . n 
A 1 193 ASP 193 214 ?   ?   ?   A . n 
A 1 194 PHE 194 215 215 PHE PHE A . n 
A 1 195 LEU 195 216 216 LEU LEU A . n 
A 1 196 ASP 196 217 217 ASP ASP A . n 
A 1 197 PRO 197 218 218 PRO PRO A . n 
A 1 198 PHE 198 219 219 PHE PHE A . n 
A 1 199 PHE 199 220 220 PHE PHE A . n 
A 1 200 LEU 200 221 221 LEU LEU A . n 
A 1 201 SER 201 222 222 SER SER A . n 
A 1 202 ILE 202 223 223 ILE ILE A . n 
A 1 203 THR 203 224 224 THR THR A . n 
A 1 204 VAL 204 225 225 VAL VAL A . n 
A 1 205 PHE 205 226 226 PHE PHE A . n 
A 1 206 PRO 206 227 227 PRO PRO A . n 
A 1 207 PHE 207 228 228 PHE PHE A . n 
A 1 208 LEU 208 229 229 LEU LEU A . n 
A 1 209 ILE 209 230 230 ILE ILE A . n 
A 1 210 PRO 210 231 231 PRO PRO A . n 
A 1 211 ILE 211 232 232 ILE ILE A . n 
A 1 212 LEU 212 233 233 LEU LEU A . n 
A 1 213 GLU 213 234 234 GLU GLU A . n 
A 1 214 VAL 214 235 235 VAL VAL A . n 
A 1 215 LEU 215 236 236 LEU LEU A . n 
A 1 216 ASN 216 237 237 ASN ASN A . n 
A 1 217 ILE 217 238 238 ILE ILE A . n 
A 1 218 CYS 218 239 239 CYS CYS A . n 
A 1 219 VAL 219 240 240 VAL VAL A . n 
A 1 220 PHE 220 241 241 PHE PHE A . n 
A 1 221 PRO 221 242 242 PRO PRO A . n 
A 1 222 ARG 222 243 243 ARG ARG A . n 
A 1 223 GLU 223 244 244 GLU GLU A . n 
A 1 224 VAL 224 245 245 VAL VAL A . n 
A 1 225 THR 225 246 246 THR THR A . n 
A 1 226 ASN 226 247 247 ASN ASN A . n 
A 1 227 PHE 227 248 248 PHE PHE A . n 
A 1 228 LEU 228 249 249 LEU LEU A . n 
A 1 229 ARG 229 250 250 ARG ARG A . n 
A 1 230 LYS 230 251 251 LYS LYS A . n 
A 1 231 SER 231 252 252 SER SER A . n 
A 1 232 VAL 232 253 253 VAL VAL A . n 
A 1 233 LYS 233 254 254 LYS LYS A . n 
A 1 234 ARG 234 255 255 ARG ARG A . n 
A 1 235 MET 235 256 256 MET MET A . n 
A 1 236 LYS 236 257 257 LYS LYS A . n 
A 1 237 GLU 237 258 258 GLU GLU A . n 
A 1 238 SER 238 259 259 SER SER A . n 
A 1 239 ARG 239 260 260 ARG ARG A . n 
A 1 240 LEU 240 261 ?   ?   ?   A . n 
A 1 241 GLU 241 262 ?   ?   ?   A . n 
A 1 242 ASP 242 263 ?   ?   ?   A . n 
A 1 243 THR 243 264 ?   ?   ?   A . n 
A 1 244 GLN 244 265 ?   ?   ?   A . n 
A 1 245 LYS 245 266 ?   ?   ?   A . n 
A 1 246 HIS 246 267 267 HIS HIS A . n 
A 1 247 ARG 247 268 268 ARG ARG A . n 
A 1 248 VAL 248 269 269 VAL VAL A . n 
A 1 249 ASP 249 270 270 ASP ASP A . n 
A 1 250 PHE 250 271 271 PHE PHE A . n 
A 1 251 LEU 251 272 272 LEU LEU A . n 
A 1 252 GLN 252 273 273 GLN GLN A . n 
A 1 253 LEU 253 274 274 LEU LEU A . n 
A 1 254 MET 254 275 275 MET MET A . n 
A 1 255 ILE 255 276 276 ILE ILE A . n 
A 1 256 ASP 256 277 277 ASP ASP A . n 
A 1 257 SER 257 278 278 SER SER A . n 
A 1 258 GLN 258 279 279 GLN GLN A . n 
A 1 259 ASN 259 280 280 ASN ASN A . n 
A 1 260 SER 260 281 281 SER SER A . n 
A 1 261 LYS 261 282 ?   ?   ?   A . n 
A 1 262 GLU 262 283 ?   ?   ?   A . n 
A 1 263 THR 263 284 ?   ?   ?   A . n 
A 1 264 GLU 264 285 ?   ?   ?   A . n 
A 1 265 SER 265 286 ?   ?   ?   A . n 
A 1 266 HIS 266 287 287 HIS HIS A . n 
A 1 267 LYS 267 288 288 LYS LYS A . n 
A 1 268 ALA 268 289 289 ALA ALA A . n 
A 1 269 LEU 269 290 290 LEU LEU A . n 
A 1 270 SER 270 291 291 SER SER A . n 
A 1 271 ASP 271 292 292 ASP ASP A . n 
A 1 272 LEU 272 293 293 LEU LEU A . n 
A 1 273 GLU 273 294 294 GLU GLU A . n 
A 1 274 LEU 274 295 295 LEU LEU A . n 
A 1 275 VAL 275 296 296 VAL VAL A . n 
A 1 276 ALA 276 297 297 ALA ALA A . n 
A 1 277 GLN 277 298 298 GLN GLN A . n 
A 1 278 SER 278 299 299 SER SER A . n 
A 1 279 ILE 279 300 300 ILE ILE A . n 
A 1 280 ILE 280 301 301 ILE ILE A . n 
A 1 281 PHE 281 302 302 PHE PHE A . n 
A 1 282 ILE 282 303 303 ILE ILE A . n 
A 1 283 PHE 283 304 304 PHE PHE A . n 
A 1 284 ALA 284 305 305 ALA ALA A . n 
A 1 285 GLY 285 306 306 GLY GLY A . n 
A 1 286 TYR 286 307 307 TYR TYR A . n 
A 1 287 GLU 287 308 308 GLU GLU A . n 
A 1 288 THR 288 309 309 THR THR A . n 
A 1 289 THR 289 310 310 THR THR A . n 
A 1 290 SER 290 311 311 SER SER A . n 
A 1 291 SER 291 312 312 SER SER A . n 
A 1 292 VAL 292 313 313 VAL VAL A . n 
A 1 293 LEU 293 314 314 LEU LEU A . n 
A 1 294 SER 294 315 315 SER SER A . n 
A 1 295 PHE 295 316 316 PHE PHE A . n 
A 1 296 ILE 296 317 317 ILE ILE A . n 
A 1 297 MET 297 318 318 MET MET A . n 
A 1 298 TYR 298 319 319 TYR TYR A . n 
A 1 299 GLU 299 320 320 GLU GLU A . n 
A 1 300 LEU 300 321 321 LEU LEU A . n 
A 1 301 ALA 301 322 322 ALA ALA A . n 
A 1 302 THR 302 323 323 THR THR A . n 
A 1 303 HIS 303 324 324 HIS HIS A . n 
A 1 304 PRO 304 325 325 PRO PRO A . n 
A 1 305 ASP 305 326 326 ASP ASP A . n 
A 1 306 VAL 306 327 327 VAL VAL A . n 
A 1 307 GLN 307 328 328 GLN GLN A . n 
A 1 308 GLN 308 329 329 GLN GLN A . n 
A 1 309 LYS 309 330 330 LYS LYS A . n 
A 1 310 LEU 310 331 331 LEU LEU A . n 
A 1 311 GLN 311 332 332 GLN GLN A . n 
A 1 312 GLU 312 333 333 GLU GLU A . n 
A 1 313 GLU 313 334 334 GLU GLU A . n 
A 1 314 ILE 314 335 335 ILE ILE A . n 
A 1 315 ASP 315 336 336 ASP ASP A . n 
A 1 316 ALA 316 337 337 ALA ALA A . n 
A 1 317 VAL 317 338 338 VAL VAL A . n 
A 1 318 LEU 318 339 339 LEU LEU A . n 
A 1 319 PRO 319 340 340 PRO PRO A . n 
A 1 320 ASN 320 341 341 ASN ASN A . n 
A 1 321 LYS 321 342 342 LYS LYS A . n 
A 1 322 ALA 322 343 343 ALA ALA A . n 
A 1 323 PRO 323 344 344 PRO PRO A . n 
A 1 324 PRO 324 345 345 PRO PRO A . n 
A 1 325 THR 325 346 346 THR THR A . n 
A 1 326 TYR 326 347 347 TYR TYR A . n 
A 1 327 ASP 327 348 348 ASP ASP A . n 
A 1 328 THR 328 349 349 THR THR A . n 
A 1 329 VAL 329 350 350 VAL VAL A . n 
A 1 330 LEU 330 351 351 LEU LEU A . n 
A 1 331 GLN 331 352 352 GLN GLN A . n 
A 1 332 MET 332 353 353 MET MET A . n 
A 1 333 GLU 333 354 354 GLU GLU A . n 
A 1 334 TYR 334 355 355 TYR TYR A . n 
A 1 335 LEU 335 356 356 LEU LEU A . n 
A 1 336 ASP 336 357 357 ASP ASP A . n 
A 1 337 MET 337 358 358 MET MET A . n 
A 1 338 VAL 338 359 359 VAL VAL A . n 
A 1 339 VAL 339 360 360 VAL VAL A . n 
A 1 340 ASN 340 361 361 ASN ASN A . n 
A 1 341 GLU 341 362 362 GLU GLU A . n 
A 1 342 THR 342 363 363 THR THR A . n 
A 1 343 LEU 343 364 364 LEU LEU A . n 
A 1 344 ARG 344 365 365 ARG ARG A . n 
A 1 345 LEU 345 366 366 LEU LEU A . n 
A 1 346 PHE 346 367 367 PHE PHE A . n 
A 1 347 PRO 347 368 368 PRO PRO A . n 
A 1 348 ILE 348 369 369 ILE ILE A . n 
A 1 349 ALA 349 370 370 ALA ALA A . n 
A 1 350 MET 350 371 371 MET MET A . n 
A 1 351 ARG 351 372 372 ARG ARG A . n 
A 1 352 LEU 352 373 373 LEU LEU A . n 
A 1 353 GLU 353 374 374 GLU GLU A . n 
A 1 354 ARG 354 375 375 ARG ARG A . n 
A 1 355 VAL 355 376 376 VAL VAL A . n 
A 1 356 CYS 356 377 377 CYS CYS A . n 
A 1 357 LYS 357 378 378 LYS LYS A . n 
A 1 358 LYS 358 379 379 LYS LYS A . n 
A 1 359 ASP 359 380 380 ASP ASP A . n 
A 1 360 VAL 360 381 381 VAL VAL A . n 
A 1 361 GLU 361 382 382 GLU GLU A . n 
A 1 362 ILE 362 383 383 ILE ILE A . n 
A 1 363 ASN 363 384 384 ASN ASN A . n 
A 1 364 GLY 364 385 385 GLY GLY A . n 
A 1 365 MET 365 386 386 MET MET A . n 
A 1 366 PHE 366 387 387 PHE PHE A . n 
A 1 367 ILE 367 388 388 ILE ILE A . n 
A 1 368 PRO 368 389 389 PRO PRO A . n 
A 1 369 LYS 369 390 390 LYS LYS A . n 
A 1 370 GLY 370 391 391 GLY GLY A . n 
A 1 371 VAL 371 392 392 VAL VAL A . n 
A 1 372 VAL 372 393 393 VAL VAL A . n 
A 1 373 VAL 373 394 394 VAL VAL A . n 
A 1 374 MET 374 395 395 MET MET A . n 
A 1 375 ILE 375 396 396 ILE ILE A . n 
A 1 376 PRO 376 397 397 PRO PRO A . n 
A 1 377 SER 377 398 398 SER SER A . n 
A 1 378 TYR 378 399 399 TYR TYR A . n 
A 1 379 ALA 379 400 400 ALA ALA A . n 
A 1 380 LEU 380 401 401 LEU LEU A . n 
A 1 381 HIS 381 402 402 HIS HIS A . n 
A 1 382 ARG 382 403 403 ARG ARG A . n 
A 1 383 ASP 383 404 404 ASP ASP A . n 
A 1 384 PRO 384 405 405 PRO PRO A . n 
A 1 385 LYS 385 406 406 LYS LYS A . n 
A 1 386 TYR 386 407 407 TYR TYR A . n 
A 1 387 TRP 387 408 408 TRP TRP A . n 
A 1 388 THR 388 409 409 THR THR A . n 
A 1 389 GLU 389 410 410 GLU GLU A . n 
A 1 390 PRO 390 411 411 PRO PRO A . n 
A 1 391 GLU 391 412 412 GLU GLU A . n 
A 1 392 LYS 392 413 413 LYS LYS A . n 
A 1 393 PHE 393 414 414 PHE PHE A . n 
A 1 394 LEU 394 415 415 LEU LEU A . n 
A 1 395 PRO 395 416 416 PRO PRO A . n 
A 1 396 GLU 396 417 417 GLU GLU A . n 
A 1 397 ARG 397 418 418 ARG ARG A . n 
A 1 398 PHE 398 419 419 PHE PHE A . n 
A 1 399 SER 399 420 420 SER SER A . n 
A 1 400 LYS 400 421 421 LYS LYS A . n 
A 1 401 LYS 401 422 422 LYS LYS A . n 
A 1 402 ASN 402 423 423 ASN ASN A . n 
A 1 403 LYS 403 424 424 LYS LYS A . n 
A 1 404 ASP 404 425 425 ASP ASP A . n 
A 1 405 ASN 405 426 426 ASN ASN A . n 
A 1 406 ILE 406 427 427 ILE ILE A . n 
A 1 407 ASP 407 428 428 ASP ASP A . n 
A 1 408 PRO 408 429 429 PRO PRO A . n 
A 1 409 TYR 409 430 430 TYR TYR A . n 
A 1 410 ILE 410 431 431 ILE ILE A . n 
A 1 411 TYR 411 432 432 TYR TYR A . n 
A 1 412 THR 412 433 433 THR THR A . n 
A 1 413 PRO 413 434 434 PRO PRO A . n 
A 1 414 PHE 414 435 435 PHE PHE A . n 
A 1 415 GLY 415 436 436 GLY GLY A . n 
A 1 416 SER 416 437 437 SER SER A . n 
A 1 417 GLY 417 438 438 GLY GLY A . n 
A 1 418 PRO 418 439 439 PRO PRO A . n 
A 1 419 ARG 419 440 440 ARG ARG A . n 
A 1 420 ASN 420 441 441 ASN ASN A . n 
A 1 421 CYS 421 442 442 CYS CYS A . n 
A 1 422 ILE 422 443 443 ILE ILE A . n 
A 1 423 GLY 423 444 444 GLY GLY A . n 
A 1 424 MET 424 445 445 MET MET A . n 
A 1 425 ARG 425 446 446 ARG ARG A . n 
A 1 426 PHE 426 447 447 PHE PHE A . n 
A 1 427 ALA 427 448 448 ALA ALA A . n 
A 1 428 LEU 428 449 449 LEU LEU A . n 
A 1 429 MET 429 450 450 MET MET A . n 
A 1 430 ASN 430 451 451 ASN ASN A . n 
A 1 431 MET 431 452 452 MET MET A . n 
A 1 432 LYS 432 453 453 LYS LYS A . n 
A 1 433 LEU 433 454 454 LEU LEU A . n 
A 1 434 ALA 434 455 455 ALA ALA A . n 
A 1 435 LEU 435 456 456 LEU LEU A . n 
A 1 436 ILE 436 457 457 ILE ILE A . n 
A 1 437 ARG 437 458 458 ARG ARG A . n 
A 1 438 VAL 438 459 459 VAL VAL A . n 
A 1 439 LEU 439 460 460 LEU LEU A . n 
A 1 440 GLN 440 461 461 GLN GLN A . n 
A 1 441 ASN 441 462 462 ASN ASN A . n 
A 1 442 PHE 442 463 463 PHE PHE A . n 
A 1 443 SER 443 464 464 SER SER A . n 
A 1 444 PHE 444 465 465 PHE PHE A . n 
A 1 445 LYS 445 466 466 LYS LYS A . n 
A 1 446 PRO 446 467 467 PRO PRO A . n 
A 1 447 CYS 447 468 468 CYS CYS A . n 
A 1 448 LYS 448 469 469 LYS LYS A . n 
A 1 449 GLU 449 470 470 GLU GLU A . n 
A 1 450 THR 450 471 471 THR THR A . n 
A 1 451 GLN 451 472 472 GLN GLN A . n 
A 1 452 ILE 452 473 473 ILE ILE A . n 
A 1 453 PRO 453 474 474 PRO PRO A . n 
A 1 454 LEU 454 475 475 LEU LEU A . n 
A 1 455 LYS 455 476 476 LYS LYS A . n 
A 1 456 LEU 456 477 477 LEU LEU A . n 
A 1 457 SER 457 478 478 SER SER A . n 
A 1 458 LEU 458 479 479 LEU LEU A . n 
A 1 459 GLY 459 480 480 GLY GLY A . n 
A 1 460 GLY 460 481 481 GLY GLY A . n 
A 1 461 LEU 461 482 482 LEU LEU A . n 
A 1 462 LEU 462 483 483 LEU LEU A . n 
A 1 463 GLN 463 484 484 GLN GLN A . n 
A 1 464 PRO 464 485 485 PRO PRO A . n 
A 1 465 GLU 465 486 486 GLU GLU A . n 
A 1 466 LYS 466 487 487 LYS LYS A . n 
A 1 467 PRO 467 488 488 PRO PRO A . n 
A 1 468 VAL 468 489 489 VAL VAL A . n 
A 1 469 VAL 469 490 490 VAL VAL A . n 
A 1 470 LEU 470 491 491 LEU LEU A . n 
A 1 471 LYS 471 492 492 LYS LYS A . n 
A 1 472 VAL 472 493 493 VAL VAL A . n 
A 1 473 GLU 473 494 494 GLU GLU A . n 
A 1 474 SER 474 495 495 SER SER A . n 
A 1 475 ARG 475 496 496 ARG ARG A . n 
A 1 476 ASP 476 497 ?   ?   ?   A . n 
A 1 477 GLY 477 498 ?   ?   ?   A . n 
A 1 478 THR 478 499 ?   ?   ?   A . n 
A 1 479 VAL 479 500 ?   ?   ?   A . n 
A 1 480 SER 480 501 ?   ?   ?   A . n 
A 1 481 GLY 481 502 ?   ?   ?   A . n 
A 1 482 ALA 482 503 ?   ?   ?   A . n 
A 1 483 HIS 483 504 ?   ?   ?   A . n 
A 1 484 HIS 484 505 ?   ?   ?   A . n 
A 1 485 HIS 485 506 ?   ?   ?   A . n 
A 1 486 HIS 486 507 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        HEM 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   HEM 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 HEM   1 601 601 HEM   HEM A . 
C 3 A1ASU 1 602 602 A1ASU C82 A . 
D 4 PG0   1 603 603 PG0   PG0 A . 
E 5 HOH   1 701 1   HOH   HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1   1 Y 1 A LYS 34  ? CG  ? A LYS 13  CG  
2   1 Y 1 A LYS 34  ? CD  ? A LYS 13  CD  
3   1 Y 1 A LYS 34  ? CE  ? A LYS 13  CE  
4   1 Y 1 A LYS 34  ? NZ  ? A LYS 13  NZ  
5   1 Y 1 A LYS 35  ? CG  ? A LYS 14  CG  
6   1 Y 1 A LYS 35  ? CD  ? A LYS 14  CD  
7   1 Y 1 A LYS 35  ? CE  ? A LYS 14  CE  
8   1 Y 1 A LYS 35  ? NZ  ? A LYS 14  NZ  
9   1 Y 1 A LYS 55  ? CG  ? A LYS 34  CG  
10  1 Y 1 A LYS 55  ? CD  ? A LYS 34  CD  
11  1 Y 1 A LYS 55  ? CE  ? A LYS 34  CE  
12  1 Y 1 A LYS 55  ? NZ  ? A LYS 34  NZ  
13  1 Y 1 A MET 59  ? CG  ? A MET 38  CG  
14  1 Y 1 A MET 59  ? SD  ? A MET 38  SD  
15  1 Y 1 A MET 59  ? CE  ? A MET 38  CE  
16  1 Y 1 A LYS 66  ? CG  ? A LYS 45  CG  
17  1 Y 1 A LYS 66  ? CD  ? A LYS 45  CD  
18  1 Y 1 A LYS 66  ? CE  ? A LYS 45  CE  
19  1 Y 1 A LYS 66  ? NZ  ? A LYS 45  NZ  
20  1 Y 1 A LYS 67  ? CG  ? A LYS 46  CG  
21  1 Y 1 A LYS 67  ? CD  ? A LYS 46  CD  
22  1 Y 1 A LYS 67  ? CE  ? A LYS 46  CE  
23  1 Y 1 A LYS 67  ? NZ  ? A LYS 46  NZ  
24  1 Y 1 A LYS 70  ? CG  ? A LYS 49  CG  
25  1 Y 1 A LYS 70  ? CD  ? A LYS 49  CD  
26  1 Y 1 A LYS 70  ? CE  ? A LYS 49  CE  
27  1 Y 1 A LYS 70  ? NZ  ? A LYS 49  NZ  
28  1 Y 1 A LYS 115 ? CG  ? A LYS 94  CG  
29  1 Y 1 A LYS 115 ? CD  ? A LYS 94  CD  
30  1 Y 1 A LYS 115 ? CE  ? A LYS 94  CE  
31  1 Y 1 A LYS 115 ? NZ  ? A LYS 94  NZ  
32  1 Y 1 A LYS 127 ? CG  ? A LYS 106 CG  
33  1 Y 1 A LYS 127 ? CD  ? A LYS 106 CD  
34  1 Y 1 A LYS 127 ? CE  ? A LYS 106 CE  
35  1 Y 1 A LYS 127 ? NZ  ? A LYS 106 NZ  
36  1 Y 1 A LYS 141 ? CG  ? A LYS 120 CG  
37  1 Y 1 A LYS 141 ? CD  ? A LYS 120 CD  
38  1 Y 1 A LYS 141 ? CE  ? A LYS 120 CE  
39  1 Y 1 A LYS 141 ? NZ  ? A LYS 120 NZ  
40  1 Y 1 A ARG 158 ? CG  ? A ARG 137 CG  
41  1 Y 1 A ARG 158 ? CD  ? A ARG 137 CD  
42  1 Y 1 A ARG 158 ? NE  ? A ARG 137 NE  
43  1 Y 1 A ARG 158 ? CZ  ? A ARG 137 CZ  
44  1 Y 1 A ARG 158 ? NH1 ? A ARG 137 NH1 
45  1 Y 1 A ARG 158 ? NH2 ? A ARG 137 NH2 
46  1 Y 1 A LEU 160 ? CG  ? A LEU 139 CG  
47  1 Y 1 A LEU 160 ? CD1 ? A LEU 139 CD1 
48  1 Y 1 A LEU 160 ? CD2 ? A LEU 139 CD2 
49  1 Y 1 A ARG 162 ? CG  ? A ARG 141 CG  
50  1 Y 1 A ARG 162 ? CD  ? A ARG 141 CD  
51  1 Y 1 A ARG 162 ? NE  ? A ARG 141 NE  
52  1 Y 1 A ARG 162 ? CZ  ? A ARG 141 CZ  
53  1 Y 1 A ARG 162 ? NH1 ? A ARG 141 NH1 
54  1 Y 1 A ARG 162 ? NH2 ? A ARG 141 NH2 
55  1 Y 1 A GLU 163 ? CG  ? A GLU 142 CG  
56  1 Y 1 A GLU 163 ? CD  ? A GLU 142 CD  
57  1 Y 1 A GLU 163 ? OE1 ? A GLU 142 OE1 
58  1 Y 1 A GLU 163 ? OE2 ? A GLU 142 OE2 
59  1 Y 1 A LYS 168 ? CG  ? A LYS 147 CG  
60  1 Y 1 A LYS 168 ? CD  ? A LYS 147 CD  
61  1 Y 1 A LYS 168 ? CE  ? A LYS 147 CE  
62  1 Y 1 A LYS 168 ? NZ  ? A LYS 147 NZ  
63  1 Y 1 A ASP 174 ? CG  ? A ASP 153 CG  
64  1 Y 1 A ASP 174 ? OD1 ? A ASP 153 OD1 
65  1 Y 1 A ASP 174 ? OD2 ? A ASP 153 OD2 
66  1 Y 1 A SER 188 ? OG  ? A SER 167 OG  
67  1 Y 1 A ILE 193 ? CG1 ? A ILE 172 CG1 
68  1 Y 1 A ILE 193 ? CG2 ? A ILE 172 CG2 
69  1 Y 1 A ILE 193 ? CD1 ? A ILE 172 CD1 
70  1 Y 1 A GLN 200 ? CG  ? A GLN 179 CG  
71  1 Y 1 A GLN 200 ? CD  ? A GLN 179 CD  
72  1 Y 1 A GLN 200 ? OE1 ? A GLN 179 OE1 
73  1 Y 1 A GLN 200 ? NE2 ? A GLN 179 NE2 
74  1 Y 1 A GLU 205 ? CG  ? A GLU 184 CG  
75  1 Y 1 A GLU 205 ? CD  ? A GLU 184 CD  
76  1 Y 1 A GLU 205 ? OE1 ? A GLU 184 OE1 
77  1 Y 1 A GLU 205 ? OE2 ? A GLU 184 OE2 
78  1 Y 1 A LYS 208 ? CG  ? A LYS 187 CG  
79  1 Y 1 A LYS 208 ? CD  ? A LYS 187 CD  
80  1 Y 1 A LYS 208 ? CE  ? A LYS 187 CE  
81  1 Y 1 A LYS 208 ? NZ  ? A LYS 187 NZ  
82  1 Y 1 A LYS 209 ? CG  ? A LYS 188 CG  
83  1 Y 1 A LYS 209 ? CD  ? A LYS 188 CD  
84  1 Y 1 A LYS 209 ? CE  ? A LYS 188 CE  
85  1 Y 1 A LYS 209 ? NZ  ? A LYS 188 NZ  
86  1 Y 1 A PHE 213 ? CG  ? A PHE 192 CG  
87  1 Y 1 A PHE 213 ? CD1 ? A PHE 192 CD1 
88  1 Y 1 A PHE 213 ? CD2 ? A PHE 192 CD2 
89  1 Y 1 A PHE 213 ? CE1 ? A PHE 192 CE1 
90  1 Y 1 A PHE 213 ? CE2 ? A PHE 192 CE2 
91  1 Y 1 A PHE 213 ? CZ  ? A PHE 192 CZ  
92  1 Y 1 A PHE 215 ? CG  ? A PHE 194 CG  
93  1 Y 1 A PHE 215 ? CD1 ? A PHE 194 CD1 
94  1 Y 1 A PHE 215 ? CD2 ? A PHE 194 CD2 
95  1 Y 1 A PHE 215 ? CE1 ? A PHE 194 CE1 
96  1 Y 1 A PHE 215 ? CE2 ? A PHE 194 CE2 
97  1 Y 1 A PHE 215 ? CZ  ? A PHE 194 CZ  
98  1 Y 1 A LEU 221 ? CG  ? A LEU 200 CG  
99  1 Y 1 A LEU 221 ? CD1 ? A LEU 200 CD1 
100 1 Y 1 A LEU 221 ? CD2 ? A LEU 200 CD2 
101 1 Y 1 A ASN 237 ? CG  ? A ASN 216 CG  
102 1 Y 1 A ASN 237 ? OD1 ? A ASN 216 OD1 
103 1 Y 1 A ASN 237 ? ND2 ? A ASN 216 ND2 
104 1 Y 1 A ARG 243 ? CG  ? A ARG 222 CG  
105 1 Y 1 A ARG 243 ? CD  ? A ARG 222 CD  
106 1 Y 1 A ARG 243 ? NE  ? A ARG 222 NE  
107 1 Y 1 A ARG 243 ? CZ  ? A ARG 222 CZ  
108 1 Y 1 A ARG 243 ? NH1 ? A ARG 222 NH1 
109 1 Y 1 A ARG 243 ? NH2 ? A ARG 222 NH2 
110 1 Y 1 A GLU 244 ? CG  ? A GLU 223 CG  
111 1 Y 1 A GLU 244 ? CD  ? A GLU 223 CD  
112 1 Y 1 A GLU 244 ? OE1 ? A GLU 223 OE1 
113 1 Y 1 A GLU 244 ? OE2 ? A GLU 223 OE2 
114 1 Y 1 A ARG 250 ? CG  ? A ARG 229 CG  
115 1 Y 1 A ARG 250 ? CD  ? A ARG 229 CD  
116 1 Y 1 A ARG 250 ? NE  ? A ARG 229 NE  
117 1 Y 1 A ARG 250 ? CZ  ? A ARG 229 CZ  
118 1 Y 1 A ARG 250 ? NH1 ? A ARG 229 NH1 
119 1 Y 1 A ARG 250 ? NH2 ? A ARG 229 NH2 
120 1 Y 1 A LYS 251 ? CG  ? A LYS 230 CG  
121 1 Y 1 A LYS 251 ? CD  ? A LYS 230 CD  
122 1 Y 1 A LYS 251 ? CE  ? A LYS 230 CE  
123 1 Y 1 A LYS 251 ? NZ  ? A LYS 230 NZ  
124 1 Y 1 A LYS 254 ? CG  ? A LYS 233 CG  
125 1 Y 1 A LYS 254 ? CD  ? A LYS 233 CD  
126 1 Y 1 A LYS 254 ? CE  ? A LYS 233 CE  
127 1 Y 1 A LYS 254 ? NZ  ? A LYS 233 NZ  
128 1 Y 1 A ARG 255 ? CG  ? A ARG 234 CG  
129 1 Y 1 A ARG 255 ? CD  ? A ARG 234 CD  
130 1 Y 1 A ARG 255 ? NE  ? A ARG 234 NE  
131 1 Y 1 A ARG 255 ? CZ  ? A ARG 234 CZ  
132 1 Y 1 A ARG 255 ? NH1 ? A ARG 234 NH1 
133 1 Y 1 A ARG 255 ? NH2 ? A ARG 234 NH2 
134 1 Y 1 A LYS 257 ? CG  ? A LYS 236 CG  
135 1 Y 1 A LYS 257 ? CD  ? A LYS 236 CD  
136 1 Y 1 A LYS 257 ? CE  ? A LYS 236 CE  
137 1 Y 1 A LYS 257 ? NZ  ? A LYS 236 NZ  
138 1 Y 1 A GLU 258 ? CG  ? A GLU 237 CG  
139 1 Y 1 A GLU 258 ? CD  ? A GLU 237 CD  
140 1 Y 1 A GLU 258 ? OE1 ? A GLU 237 OE1 
141 1 Y 1 A GLU 258 ? OE2 ? A GLU 237 OE2 
142 1 Y 1 A SER 259 ? OG  ? A SER 238 OG  
143 1 Y 1 A ARG 260 ? CG  ? A ARG 239 CG  
144 1 Y 1 A ARG 260 ? CD  ? A ARG 239 CD  
145 1 Y 1 A ARG 260 ? NE  ? A ARG 239 NE  
146 1 Y 1 A ARG 260 ? CZ  ? A ARG 239 CZ  
147 1 Y 1 A ARG 260 ? NH1 ? A ARG 239 NH1 
148 1 Y 1 A ARG 260 ? NH2 ? A ARG 239 NH2 
149 1 Y 1 A HIS 267 ? CG  ? A HIS 246 CG  
150 1 Y 1 A HIS 267 ? ND1 ? A HIS 246 ND1 
151 1 Y 1 A HIS 267 ? CD2 ? A HIS 246 CD2 
152 1 Y 1 A HIS 267 ? CE1 ? A HIS 246 CE1 
153 1 Y 1 A HIS 267 ? NE2 ? A HIS 246 NE2 
154 1 Y 1 A ARG 268 ? CG  ? A ARG 247 CG  
155 1 Y 1 A ARG 268 ? CD  ? A ARG 247 CD  
156 1 Y 1 A ARG 268 ? NE  ? A ARG 247 NE  
157 1 Y 1 A ARG 268 ? CZ  ? A ARG 247 CZ  
158 1 Y 1 A ARG 268 ? NH1 ? A ARG 247 NH1 
159 1 Y 1 A ARG 268 ? NH2 ? A ARG 247 NH2 
160 1 Y 1 A GLN 273 ? CG  ? A GLN 252 CG  
161 1 Y 1 A GLN 273 ? CD  ? A GLN 252 CD  
162 1 Y 1 A GLN 273 ? OE1 ? A GLN 252 OE1 
163 1 Y 1 A GLN 273 ? NE2 ? A GLN 252 NE2 
164 1 Y 1 A SER 281 ? OG  ? A SER 260 OG  
165 1 Y 1 A HIS 287 ? CG  ? A HIS 266 CG  
166 1 Y 1 A HIS 287 ? ND1 ? A HIS 266 ND1 
167 1 Y 1 A HIS 287 ? CD2 ? A HIS 266 CD2 
168 1 Y 1 A HIS 287 ? CE1 ? A HIS 266 CE1 
169 1 Y 1 A HIS 287 ? NE2 ? A HIS 266 NE2 
170 1 Y 1 A LYS 288 ? CG  ? A LYS 267 CG  
171 1 Y 1 A LYS 288 ? CD  ? A LYS 267 CD  
172 1 Y 1 A LYS 288 ? CE  ? A LYS 267 CE  
173 1 Y 1 A LYS 288 ? NZ  ? A LYS 267 NZ  
174 1 Y 1 A LEU 293 ? CG  ? A LEU 272 CG  
175 1 Y 1 A LEU 293 ? CD1 ? A LEU 272 CD1 
176 1 Y 1 A LEU 293 ? CD2 ? A LEU 272 CD2 
177 1 Y 1 A ILE 303 ? CG1 ? A ILE 282 CG1 
178 1 Y 1 A ILE 303 ? CG2 ? A ILE 282 CG2 
179 1 Y 1 A ILE 303 ? CD1 ? A ILE 282 CD1 
180 1 Y 1 A ILE 335 ? CG1 ? A ILE 314 CG1 
181 1 Y 1 A ILE 335 ? CG2 ? A ILE 314 CG2 
182 1 Y 1 A ILE 335 ? CD1 ? A ILE 314 CD1 
183 1 Y 1 A ASN 341 ? CG  ? A ASN 320 CG  
184 1 Y 1 A ASN 341 ? OD1 ? A ASN 320 OD1 
185 1 Y 1 A ASN 341 ? ND2 ? A ASN 320 ND2 
186 1 Y 1 A LYS 342 ? CG  ? A LYS 321 CG  
187 1 Y 1 A LYS 342 ? CD  ? A LYS 321 CD  
188 1 Y 1 A LYS 342 ? CE  ? A LYS 321 CE  
189 1 Y 1 A LYS 342 ? NZ  ? A LYS 321 NZ  
190 1 Y 1 A GLN 352 ? CG  ? A GLN 331 CG  
191 1 Y 1 A GLN 352 ? CD  ? A GLN 331 CD  
192 1 Y 1 A GLN 352 ? OE1 ? A GLN 331 OE1 
193 1 Y 1 A GLN 352 ? NE2 ? A GLN 331 NE2 
194 1 Y 1 A LYS 379 ? CG  ? A LYS 358 CG  
195 1 Y 1 A LYS 379 ? CD  ? A LYS 358 CD  
196 1 Y 1 A LYS 379 ? CE  ? A LYS 358 CE  
197 1 Y 1 A LYS 379 ? NZ  ? A LYS 358 NZ  
198 1 Y 1 A GLU 417 ? CG  ? A GLU 396 CG  
199 1 Y 1 A GLU 417 ? CD  ? A GLU 396 CD  
200 1 Y 1 A GLU 417 ? OE1 ? A GLU 396 OE1 
201 1 Y 1 A GLU 417 ? OE2 ? A GLU 396 OE2 
202 1 Y 1 A LYS 421 ? CG  ? A LYS 400 CG  
203 1 Y 1 A LYS 421 ? CD  ? A LYS 400 CD  
204 1 Y 1 A LYS 421 ? CE  ? A LYS 400 CE  
205 1 Y 1 A LYS 421 ? NZ  ? A LYS 400 NZ  
206 1 Y 1 A LYS 422 ? CG  ? A LYS 401 CG  
207 1 Y 1 A LYS 422 ? CD  ? A LYS 401 CD  
208 1 Y 1 A LYS 422 ? CE  ? A LYS 401 CE  
209 1 Y 1 A LYS 422 ? NZ  ? A LYS 401 NZ  
210 1 Y 1 A ILE 427 ? CG1 ? A ILE 406 CG1 
211 1 Y 1 A ILE 427 ? CG2 ? A ILE 406 CG2 
212 1 Y 1 A ILE 427 ? CD1 ? A ILE 406 CD1 
213 1 Y 1 A LYS 466 ? CG  ? A LYS 445 CG  
214 1 Y 1 A LYS 466 ? CD  ? A LYS 445 CD  
215 1 Y 1 A LYS 466 ? CE  ? A LYS 445 CE  
216 1 Y 1 A LYS 466 ? NZ  ? A LYS 445 NZ  
217 1 Y 1 A LYS 487 ? CG  ? A LYS 466 CG  
218 1 Y 1 A LYS 487 ? CD  ? A LYS 466 CD  
219 1 Y 1 A LYS 487 ? CE  ? A LYS 466 CE  
220 1 Y 1 A LYS 487 ? NZ  ? A LYS 466 NZ  
221 1 Y 1 A LYS 492 ? CG  ? A LYS 471 CG  
222 1 Y 1 A LYS 492 ? CD  ? A LYS 471 CD  
223 1 Y 1 A LYS 492 ? CE  ? A LYS 471 CE  
224 1 Y 1 A LYS 492 ? NZ  ? A LYS 471 NZ  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? '(1.20.1_4487)' 1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XSCALE ? ? ? .               2 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .               3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? .               4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BV6 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     75.878 
_cell.length_a_esd                 ? 
_cell.length_b                     100.692 
_cell.length_b_esd                 ? 
_cell.length_c                     123.090 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BV6 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                23 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'I 2 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BV6 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.11 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          41.83 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.0 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M sodium malonate, pH 7.0, 22% PEG 2000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2020-03-18 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    'SI(111)' 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.9794 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSLS-II BEAMLINE 17-ID-2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.9794 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   17-ID-2 
_diffrn_source.pdbx_synchrotron_site       NSLS-II 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9BV6 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              3.10 
_reflns.d_resolution_low                               43.18 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     8850 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.9 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                10.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          15.2 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               0.95 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.104 
_reflns.pdbx_Rpim_I_all                                0.032 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.995 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.098 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    3.10 
_reflns_shell.d_res_low                                     3.32 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.6 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1575 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               11.2 
_reflns_shell.pdbx_chi_squared                              0.74 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               0.387 
_reflns_shell.pdbx_Rpim_I_all                               0.281 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.837 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.4 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.916 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9BV6 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            3.10 
_refine.ls_d_res_low                             43.18 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     8844 
_refine.ls_number_reflns_R_free                  442 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.81 
_refine.ls_percent_reflns_R_free                 5.00 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2466 
_refine.ls_R_factor_R_free                       0.2682 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2455 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 35.02 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.35 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       3.10 
_refine_hist.d_res_low                        43.18 
_refine_hist.number_atoms_solvent             1 
_refine_hist.number_atoms_total               3526 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        3449 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         76 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.002  ? 3623 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.507  ? 4958 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 11.923 ? 1265 ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.039  ? 563  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.004  ? 632  ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 3.10 3.55  . . 146 2743 100.00 . . . . 0.3191 . . . . . . . . . . . 0.3882 
'X-RAY DIFFRACTION' 3.55 4.47  . . 145 2772 100.00 . . . . 0.2735 . . . . . . . . . . . 0.2895 
'X-RAY DIFFRACTION' 4.47 43.18 . . 151 2887 100.00 . . . . 0.2133 . . . . . . . . . . . 0.2413 
# 
_struct.entry_id                     9BV6 
_struct.title                        'Crystal structure of human CYP3A4 in complex with SJ000388260' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BV6 
_struct_keywords.text            
;Cytochrome P450 3A4, CYP3A4, CYP3A4-selective inhibitor, drug metabolizing enzyme, OXIDOREDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
;
_struct_keywords.pdbx_keywords   'OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    CP3A4_HUMAN 
_struct_ref.pdbx_db_accession          P08684 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;LYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFT
NRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV
ITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLED
TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKA
PPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKN
KDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTVSGA

;
_struct_ref.pdbx_align_begin           24 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9BV6 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 3 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 482 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P08684 
_struct_ref_seq.db_align_beg                  24 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  503 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       24 
_struct_ref_seq.pdbx_auth_seq_align_end       503 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9BV6 MET A 1   ? UNP P08684 ? ? 'initiating methionine' 22  1 
1 9BV6 ALA A 2   ? UNP P08684 ? ? 'expression tag'        23  2 
1 9BV6 HIS A 483 ? UNP P08684 ? ? 'expression tag'        504 3 
1 9BV6 HIS A 484 ? UNP P08684 ? ? 'expression tag'        505 4 
1 9BV6 HIS A 485 ? UNP P08684 ? ? 'expression tag'        506 5 
1 9BV6 HIS A 486 ? UNP P08684 ? ? 'expression tag'        507 6 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLY A 10  ? LEU A 15  ? GLY A 31  LEU A 36  1 ? 6  
HELX_P HELX_P2  AA2 ASN A 28  ? HIS A 33  ? ASN A 49  HIS A 54  5 ? 6  
HELX_P HELX_P3  AA3 LYS A 34  ? GLY A 48  ? LYS A 55  GLY A 69  1 ? 15 
HELX_P HELX_P4  AA4 ASP A 65  ? VAL A 74  ? ASP A 86  VAL A 95  1 ? 10 
HELX_P HELX_P5  AA5 VAL A 90  ? ALA A 96  ? VAL A 111 ALA A 117 5 ? 7  
HELX_P HELX_P6  AA6 GLU A 101 ? SER A 113 ? GLU A 122 SER A 134 1 ? 13 
HELX_P HELX_P7  AA7 PRO A 114 ? PHE A 116 ? PRO A 135 PHE A 137 5 ? 3  
HELX_P HELX_P8  AA8 THR A 117 ? GLU A 123 ? THR A 138 GLU A 144 1 ? 7  
HELX_P HELX_P9  AA9 MET A 124 ? GLU A 144 ? MET A 145 GLU A 165 1 ? 21 
HELX_P HELX_P10 AB1 LEU A 151 ? PHE A 168 ? LEU A 172 PHE A 189 1 ? 18 
HELX_P HELX_P11 AB2 ASP A 180 ? LYS A 188 ? ASP A 201 LYS A 209 1 ? 9  
HELX_P HELX_P12 AB3 ASP A 196 ? PHE A 205 ? ASP A 217 PHE A 226 1 ? 10 
HELX_P HELX_P13 AB4 LEU A 208 ? LEU A 215 ? LEU A 229 LEU A 236 1 ? 8  
HELX_P HELX_P14 AB5 PRO A 221 ? ARG A 239 ? PRO A 242 ARG A 260 1 ? 19 
HELX_P HELX_P15 AB6 ASP A 249 ? SER A 260 ? ASP A 270 SER A 281 1 ? 12 
HELX_P HELX_P16 AB7 SER A 270 ? HIS A 303 ? SER A 291 HIS A 324 1 ? 34 
HELX_P HELX_P17 AB8 HIS A 303 ? LEU A 318 ? HIS A 324 LEU A 339 1 ? 16 
HELX_P HELX_P18 AB9 THR A 325 ? MET A 332 ? THR A 346 MET A 353 1 ? 8  
HELX_P HELX_P19 AC1 MET A 332 ? PHE A 346 ? MET A 353 PHE A 367 1 ? 15 
HELX_P HELX_P20 AC2 PRO A 376 ? ARG A 382 ? PRO A 397 ARG A 403 1 ? 7  
HELX_P HELX_P21 AC3 LEU A 394 ? PHE A 398 ? LEU A 415 PHE A 419 5 ? 5  
HELX_P HELX_P22 AC4 SER A 399 ? ASP A 404 ? SER A 420 ASP A 425 1 ? 6  
HELX_P HELX_P23 AC5 SER A 416 ? ASN A 420 ? SER A 437 ASN A 441 5 ? 5  
HELX_P HELX_P24 AC6 GLY A 423 ? ASN A 441 ? GLY A 444 ASN A 462 1 ? 19 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A CYS 421 SG ? ? ? 1_555 B HEM   . FE  ? ? A CYS 442 A HEM   601 1_555 ? ? ? ? ? ? ? 2.259 ? ? 
metalc2 metalc ? ? B HEM .   FE ? ? ? 1_555 C A1ASU . N11 ? ? A HEM 601 A A1ASU 602 1_555 ? ? ? ? ? ? ? 2.207 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  SG ? A CYS 421 ? A CYS 442 ? 1_555 FE ? B HEM . ? A HEM 601 ? 1_555 NA  ? B HEM   . ? A HEM   601 ? 1_555 96.8  ? 
2  SG ? A CYS 421 ? A CYS 442 ? 1_555 FE ? B HEM . ? A HEM 601 ? 1_555 NB  ? B HEM   . ? A HEM   601 ? 1_555 85.6  ? 
3  NA ? B HEM .   ? A HEM 601 ? 1_555 FE ? B HEM . ? A HEM 601 ? 1_555 NB  ? B HEM   . ? A HEM   601 ? 1_555 87.7  ? 
4  SG ? A CYS 421 ? A CYS 442 ? 1_555 FE ? B HEM . ? A HEM 601 ? 1_555 NC  ? B HEM   . ? A HEM   601 ? 1_555 86.3  ? 
5  NA ? B HEM .   ? A HEM 601 ? 1_555 FE ? B HEM . ? A HEM 601 ? 1_555 NC  ? B HEM   . ? A HEM   601 ? 1_555 176.7 ? 
6  NB ? B HEM .   ? A HEM 601 ? 1_555 FE ? B HEM . ? A HEM 601 ? 1_555 NC  ? B HEM   . ? A HEM   601 ? 1_555 93.7  ? 
7  SG ? A CYS 421 ? A CYS 442 ? 1_555 FE ? B HEM . ? A HEM 601 ? 1_555 ND  ? B HEM   . ? A HEM   601 ? 1_555 97.1  ? 
8  NA ? B HEM .   ? A HEM 601 ? 1_555 FE ? B HEM . ? A HEM 601 ? 1_555 ND  ? B HEM   . ? A HEM   601 ? 1_555 90.3  ? 
9  NB ? B HEM .   ? A HEM 601 ? 1_555 FE ? B HEM . ? A HEM 601 ? 1_555 ND  ? B HEM   . ? A HEM   601 ? 1_555 176.8 ? 
10 NC ? B HEM .   ? A HEM 601 ? 1_555 FE ? B HEM . ? A HEM 601 ? 1_555 ND  ? B HEM   . ? A HEM   601 ? 1_555 88.1  ? 
11 SG ? A CYS 421 ? A CYS 442 ? 1_555 FE ? B HEM . ? A HEM 601 ? 1_555 N11 ? C A1ASU . ? A A1ASU 602 ? 1_555 177.8 ? 
12 NA ? B HEM .   ? A HEM 601 ? 1_555 FE ? B HEM . ? A HEM 601 ? 1_555 N11 ? C A1ASU . ? A A1ASU 602 ? 1_555 81.2  ? 
13 NB ? B HEM .   ? A HEM 601 ? 1_555 FE ? B HEM . ? A HEM 601 ? 1_555 N11 ? C A1ASU . ? A A1ASU 602 ? 1_555 95.1  ? 
14 NC ? B HEM .   ? A HEM 601 ? 1_555 FE ? B HEM . ? A HEM 601 ? 1_555 N11 ? C A1ASU . ? A A1ASU 602 ? 1_555 95.7  ? 
15 ND ? B HEM .   ? A HEM 601 ? 1_555 FE ? B HEM . ? A HEM 601 ? 1_555 N11 ? C A1ASU . ? A A1ASU 602 ? 1_555 82.0  ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 3 ? 
AA3 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? parallel      
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA3 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 TRP A 51  ? ASP A 55  ? TRP A 72  ASP A 76  
AA1 2 GLN A 58  ? ALA A 62  ? GLN A 79  ALA A 83  
AA1 3 VAL A 372 ? ILE A 375 ? VAL A 393 ILE A 396 
AA1 4 LEU A 352 ? CYS A 356 ? LEU A 373 CYS A 377 
AA1 5 PHE A 81  ? ASN A 83  ? PHE A 102 ASN A 104 
AA2 1 VAL A 149 ? THR A 150 ? VAL A 170 THR A 171 
AA2 2 VAL A 469 ? SER A 474 ? VAL A 490 SER A 495 
AA2 3 PHE A 442 ? PRO A 446 ? PHE A 463 PRO A 467 
AA3 1 VAL A 360 ? GLU A 361 ? VAL A 381 GLU A 382 
AA3 2 PHE A 366 ? ILE A 367 ? PHE A 387 ILE A 388 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N PHE A 53  ? N PHE A 74  O VAL A 60  ? O VAL A 81  
AA1 2 3 N LEU A 61  ? N LEU A 82  O MET A 374 ? O MET A 395 
AA1 3 4 O ILE A 375 ? O ILE A 396 N LEU A 352 ? N LEU A 373 
AA1 4 5 O VAL A 355 ? O VAL A 376 N ASN A 83  ? N ASN A 104 
AA2 1 2 N VAL A 149 ? N VAL A 170 O LEU A 470 ? O LEU A 491 
AA2 2 3 O LYS A 471 ? O LYS A 492 N LYS A 445 ? N LYS A 466 
AA3 1 2 N VAL A 360 ? N VAL A 381 O ILE A 367 ? O ILE A 388 
# 
_pdbx_entry_details.entry_id                   9BV6 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 PHE A 46  ? ? 70.20   -8.36   
2 1 VAL A 95  ? ? -122.72 -60.68  
3 1 VAL A 101 ? ? -123.74 -62.14  
4 1 ASP A 123 ? ? 59.37   -130.43 
5 1 LEU A 210 ? ? -170.73 143.09  
6 1 PHE A 226 ? ? -118.86 63.94   
7 1 MET A 371 ? ? 71.31   -9.97   
8 1 CYS A 468 ? ? -123.12 -169.11 
9 1 GLU A 470 ? ? -94.19  50.76   
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 22  ? A MET 1   
2  1 Y 1 A ALA 23  ? A ALA 2   
3  1 Y 1 A LEU 24  ? A LEU 3   
4  1 Y 1 A TYR 25  ? A TYR 4   
5  1 Y 1 A GLY 26  ? A GLY 5   
6  1 Y 1 A THR 27  ? A THR 6   
7  1 Y 1 A HIS 28  ? A HIS 7   
8  1 Y 1 A ASP 214 ? A ASP 193 
9  1 Y 1 A LEU 261 ? A LEU 240 
10 1 Y 1 A GLU 262 ? A GLU 241 
11 1 Y 1 A ASP 263 ? A ASP 242 
12 1 Y 1 A THR 264 ? A THR 243 
13 1 Y 1 A GLN 265 ? A GLN 244 
14 1 Y 1 A LYS 266 ? A LYS 245 
15 1 Y 1 A LYS 282 ? A LYS 261 
16 1 Y 1 A GLU 283 ? A GLU 262 
17 1 Y 1 A THR 284 ? A THR 263 
18 1 Y 1 A GLU 285 ? A GLU 264 
19 1 Y 1 A SER 286 ? A SER 265 
20 1 Y 1 A ASP 497 ? A ASP 476 
21 1 Y 1 A GLY 498 ? A GLY 477 
22 1 Y 1 A THR 499 ? A THR 478 
23 1 Y 1 A VAL 500 ? A VAL 479 
24 1 Y 1 A SER 501 ? A SER 480 
25 1 Y 1 A GLY 502 ? A GLY 481 
26 1 Y 1 A ALA 503 ? A ALA 482 
27 1 Y 1 A HIS 504 ? A HIS 483 
28 1 Y 1 A HIS 505 ? A HIS 484 
29 1 Y 1 A HIS 506 ? A HIS 485 
30 1 Y 1 A HIS 507 ? A HIS 486 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1ASU C01  C  N N 1   
A1ASU C03  C  Y N 2   
A1ASU C04  C  Y N 3   
A1ASU C05  C  Y N 4   
A1ASU C06  C  Y N 5   
A1ASU C07  C  Y N 6   
A1ASU C08  C  Y N 7   
A1ASU C09  C  Y N 8   
A1ASU C10  C  Y N 9   
A1ASU C14  C  Y N 10  
A1ASU C15  C  Y N 11  
A1ASU C16  C  Y N 12  
A1ASU C17  C  Y N 13  
A1ASU C18  C  Y N 14  
A1ASU C19  C  Y N 15  
A1ASU C20  C  Y N 16  
A1ASU C21  C  Y N 17  
A1ASU C23  C  Y N 18  
A1ASU C24  C  N N 19  
A1ASU N11  N  Y N 20  
A1ASU N12  N  Y N 21  
A1ASU N13  N  Y N 22  
A1ASU N25  N  Y N 23  
A1ASU O02  O  N N 24  
A1ASU S22  S  Y N 25  
A1ASU H1   H  N N 26  
A1ASU H2   H  N N 27  
A1ASU H3   H  N N 28  
A1ASU H4   H  N N 29  
A1ASU H5   H  N N 30  
A1ASU H6   H  N N 31  
A1ASU H7   H  N N 32  
A1ASU H8   H  N N 33  
A1ASU H9   H  N N 34  
A1ASU H10  H  N N 35  
A1ASU H11  H  N N 36  
A1ASU H12  H  N N 37  
A1ASU H13  H  N N 38  
A1ASU H14  H  N N 39  
A1ASU H15  H  N N 40  
A1ASU H16  H  N N 41  
ALA   N    N  N N 42  
ALA   CA   C  N S 43  
ALA   C    C  N N 44  
ALA   O    O  N N 45  
ALA   CB   C  N N 46  
ALA   OXT  O  N N 47  
ALA   H    H  N N 48  
ALA   H2   H  N N 49  
ALA   HA   H  N N 50  
ALA   HB1  H  N N 51  
ALA   HB2  H  N N 52  
ALA   HB3  H  N N 53  
ALA   HXT  H  N N 54  
ARG   N    N  N N 55  
ARG   CA   C  N S 56  
ARG   C    C  N N 57  
ARG   O    O  N N 58  
ARG   CB   C  N N 59  
ARG   CG   C  N N 60  
ARG   CD   C  N N 61  
ARG   NE   N  N N 62  
ARG   CZ   C  N N 63  
ARG   NH1  N  N N 64  
ARG   NH2  N  N N 65  
ARG   OXT  O  N N 66  
ARG   H    H  N N 67  
ARG   H2   H  N N 68  
ARG   HA   H  N N 69  
ARG   HB2  H  N N 70  
ARG   HB3  H  N N 71  
ARG   HG2  H  N N 72  
ARG   HG3  H  N N 73  
ARG   HD2  H  N N 74  
ARG   HD3  H  N N 75  
ARG   HE   H  N N 76  
ARG   HH11 H  N N 77  
ARG   HH12 H  N N 78  
ARG   HH21 H  N N 79  
ARG   HH22 H  N N 80  
ARG   HXT  H  N N 81  
ASN   N    N  N N 82  
ASN   CA   C  N S 83  
ASN   C    C  N N 84  
ASN   O    O  N N 85  
ASN   CB   C  N N 86  
ASN   CG   C  N N 87  
ASN   OD1  O  N N 88  
ASN   ND2  N  N N 89  
ASN   OXT  O  N N 90  
ASN   H    H  N N 91  
ASN   H2   H  N N 92  
ASN   HA   H  N N 93  
ASN   HB2  H  N N 94  
ASN   HB3  H  N N 95  
ASN   HD21 H  N N 96  
ASN   HD22 H  N N 97  
ASN   HXT  H  N N 98  
ASP   N    N  N N 99  
ASP   CA   C  N S 100 
ASP   C    C  N N 101 
ASP   O    O  N N 102 
ASP   CB   C  N N 103 
ASP   CG   C  N N 104 
ASP   OD1  O  N N 105 
ASP   OD2  O  N N 106 
ASP   OXT  O  N N 107 
ASP   H    H  N N 108 
ASP   H2   H  N N 109 
ASP   HA   H  N N 110 
ASP   HB2  H  N N 111 
ASP   HB3  H  N N 112 
ASP   HD2  H  N N 113 
ASP   HXT  H  N N 114 
CYS   N    N  N N 115 
CYS   CA   C  N R 116 
CYS   C    C  N N 117 
CYS   O    O  N N 118 
CYS   CB   C  N N 119 
CYS   SG   S  N N 120 
CYS   OXT  O  N N 121 
CYS   H    H  N N 122 
CYS   H2   H  N N 123 
CYS   HA   H  N N 124 
CYS   HB2  H  N N 125 
CYS   HB3  H  N N 126 
CYS   HG   H  N N 127 
CYS   HXT  H  N N 128 
GLN   N    N  N N 129 
GLN   CA   C  N S 130 
GLN   C    C  N N 131 
GLN   O    O  N N 132 
GLN   CB   C  N N 133 
GLN   CG   C  N N 134 
GLN   CD   C  N N 135 
GLN   OE1  O  N N 136 
GLN   NE2  N  N N 137 
GLN   OXT  O  N N 138 
GLN   H    H  N N 139 
GLN   H2   H  N N 140 
GLN   HA   H  N N 141 
GLN   HB2  H  N N 142 
GLN   HB3  H  N N 143 
GLN   HG2  H  N N 144 
GLN   HG3  H  N N 145 
GLN   HE21 H  N N 146 
GLN   HE22 H  N N 147 
GLN   HXT  H  N N 148 
GLU   N    N  N N 149 
GLU   CA   C  N S 150 
GLU   C    C  N N 151 
GLU   O    O  N N 152 
GLU   CB   C  N N 153 
GLU   CG   C  N N 154 
GLU   CD   C  N N 155 
GLU   OE1  O  N N 156 
GLU   OE2  O  N N 157 
GLU   OXT  O  N N 158 
GLU   H    H  N N 159 
GLU   H2   H  N N 160 
GLU   HA   H  N N 161 
GLU   HB2  H  N N 162 
GLU   HB3  H  N N 163 
GLU   HG2  H  N N 164 
GLU   HG3  H  N N 165 
GLU   HE2  H  N N 166 
GLU   HXT  H  N N 167 
GLY   N    N  N N 168 
GLY   CA   C  N N 169 
GLY   C    C  N N 170 
GLY   O    O  N N 171 
GLY   OXT  O  N N 172 
GLY   H    H  N N 173 
GLY   H2   H  N N 174 
GLY   HA2  H  N N 175 
GLY   HA3  H  N N 176 
GLY   HXT  H  N N 177 
HEM   CHA  C  N N 178 
HEM   CHB  C  N N 179 
HEM   CHC  C  N N 180 
HEM   CHD  C  N N 181 
HEM   C1A  C  Y N 182 
HEM   C2A  C  Y N 183 
HEM   C3A  C  Y N 184 
HEM   C4A  C  Y N 185 
HEM   CMA  C  N N 186 
HEM   CAA  C  N N 187 
HEM   CBA  C  N N 188 
HEM   CGA  C  N N 189 
HEM   O1A  O  N N 190 
HEM   O2A  O  N N 191 
HEM   C1B  C  N N 192 
HEM   C2B  C  N N 193 
HEM   C3B  C  N N 194 
HEM   C4B  C  N N 195 
HEM   CMB  C  N N 196 
HEM   CAB  C  N N 197 
HEM   CBB  C  N N 198 
HEM   C1C  C  Y N 199 
HEM   C2C  C  Y N 200 
HEM   C3C  C  Y N 201 
HEM   C4C  C  Y N 202 
HEM   CMC  C  N N 203 
HEM   CAC  C  N N 204 
HEM   CBC  C  N N 205 
HEM   C1D  C  N N 206 
HEM   C2D  C  N N 207 
HEM   C3D  C  N N 208 
HEM   C4D  C  N N 209 
HEM   CMD  C  N N 210 
HEM   CAD  C  N N 211 
HEM   CBD  C  N N 212 
HEM   CGD  C  N N 213 
HEM   O1D  O  N N 214 
HEM   O2D  O  N N 215 
HEM   NA   N  Y N 216 
HEM   NB   N  N N 217 
HEM   NC   N  Y N 218 
HEM   ND   N  N N 219 
HEM   FE   FE N N 220 
HEM   HHB  H  N N 221 
HEM   HHC  H  N N 222 
HEM   HHD  H  N N 223 
HEM   HMA  H  N N 224 
HEM   HMAA H  N N 225 
HEM   HMAB H  N N 226 
HEM   HAA  H  N N 227 
HEM   HAAA H  N N 228 
HEM   HBA  H  N N 229 
HEM   HBAA H  N N 230 
HEM   HMB  H  N N 231 
HEM   HMBA H  N N 232 
HEM   HMBB H  N N 233 
HEM   HAB  H  N N 234 
HEM   HBB  H  N N 235 
HEM   HBBA H  N N 236 
HEM   HMC  H  N N 237 
HEM   HMCA H  N N 238 
HEM   HMCB H  N N 239 
HEM   HAC  H  N N 240 
HEM   HBC  H  N N 241 
HEM   HBCA H  N N 242 
HEM   HMD  H  N N 243 
HEM   HMDA H  N N 244 
HEM   HMDB H  N N 245 
HEM   HAD  H  N N 246 
HEM   HADA H  N N 247 
HEM   HBD  H  N N 248 
HEM   HBDA H  N N 249 
HEM   H2A  H  N N 250 
HEM   H2D  H  N N 251 
HEM   HHA  H  N N 252 
HIS   N    N  N N 253 
HIS   CA   C  N S 254 
HIS   C    C  N N 255 
HIS   O    O  N N 256 
HIS   CB   C  N N 257 
HIS   CG   C  Y N 258 
HIS   ND1  N  Y N 259 
HIS   CD2  C  Y N 260 
HIS   CE1  C  Y N 261 
HIS   NE2  N  Y N 262 
HIS   OXT  O  N N 263 
HIS   H    H  N N 264 
HIS   H2   H  N N 265 
HIS   HA   H  N N 266 
HIS   HB2  H  N N 267 
HIS   HB3  H  N N 268 
HIS   HD1  H  N N 269 
HIS   HD2  H  N N 270 
HIS   HE1  H  N N 271 
HIS   HE2  H  N N 272 
HIS   HXT  H  N N 273 
HOH   O    O  N N 274 
HOH   H1   H  N N 275 
HOH   H2   H  N N 276 
ILE   N    N  N N 277 
ILE   CA   C  N S 278 
ILE   C    C  N N 279 
ILE   O    O  N N 280 
ILE   CB   C  N S 281 
ILE   CG1  C  N N 282 
ILE   CG2  C  N N 283 
ILE   CD1  C  N N 284 
ILE   OXT  O  N N 285 
ILE   H    H  N N 286 
ILE   H2   H  N N 287 
ILE   HA   H  N N 288 
ILE   HB   H  N N 289 
ILE   HG12 H  N N 290 
ILE   HG13 H  N N 291 
ILE   HG21 H  N N 292 
ILE   HG22 H  N N 293 
ILE   HG23 H  N N 294 
ILE   HD11 H  N N 295 
ILE   HD12 H  N N 296 
ILE   HD13 H  N N 297 
ILE   HXT  H  N N 298 
LEU   N    N  N N 299 
LEU   CA   C  N S 300 
LEU   C    C  N N 301 
LEU   O    O  N N 302 
LEU   CB   C  N N 303 
LEU   CG   C  N N 304 
LEU   CD1  C  N N 305 
LEU   CD2  C  N N 306 
LEU   OXT  O  N N 307 
LEU   H    H  N N 308 
LEU   H2   H  N N 309 
LEU   HA   H  N N 310 
LEU   HB2  H  N N 311 
LEU   HB3  H  N N 312 
LEU   HG   H  N N 313 
LEU   HD11 H  N N 314 
LEU   HD12 H  N N 315 
LEU   HD13 H  N N 316 
LEU   HD21 H  N N 317 
LEU   HD22 H  N N 318 
LEU   HD23 H  N N 319 
LEU   HXT  H  N N 320 
LYS   N    N  N N 321 
LYS   CA   C  N S 322 
LYS   C    C  N N 323 
LYS   O    O  N N 324 
LYS   CB   C  N N 325 
LYS   CG   C  N N 326 
LYS   CD   C  N N 327 
LYS   CE   C  N N 328 
LYS   NZ   N  N N 329 
LYS   OXT  O  N N 330 
LYS   H    H  N N 331 
LYS   H2   H  N N 332 
LYS   HA   H  N N 333 
LYS   HB2  H  N N 334 
LYS   HB3  H  N N 335 
LYS   HG2  H  N N 336 
LYS   HG3  H  N N 337 
LYS   HD2  H  N N 338 
LYS   HD3  H  N N 339 
LYS   HE2  H  N N 340 
LYS   HE3  H  N N 341 
LYS   HZ1  H  N N 342 
LYS   HZ2  H  N N 343 
LYS   HZ3  H  N N 344 
LYS   HXT  H  N N 345 
MET   N    N  N N 346 
MET   CA   C  N S 347 
MET   C    C  N N 348 
MET   O    O  N N 349 
MET   CB   C  N N 350 
MET   CG   C  N N 351 
MET   SD   S  N N 352 
MET   CE   C  N N 353 
MET   OXT  O  N N 354 
MET   H    H  N N 355 
MET   H2   H  N N 356 
MET   HA   H  N N 357 
MET   HB2  H  N N 358 
MET   HB3  H  N N 359 
MET   HG2  H  N N 360 
MET   HG3  H  N N 361 
MET   HE1  H  N N 362 
MET   HE2  H  N N 363 
MET   HE3  H  N N 364 
MET   HXT  H  N N 365 
PG0   C5   C  N N 366 
PG0   O2   O  N N 367 
PG0   C4   C  N N 368 
PG0   C3   C  N N 369 
PG0   O1   O  N N 370 
PG0   C2   C  N N 371 
PG0   C1   C  N N 372 
PG0   OTT  O  N N 373 
PG0   H51  H  N N 374 
PG0   H52  H  N N 375 
PG0   H53  H  N N 376 
PG0   H41  H  N N 377 
PG0   H42  H  N N 378 
PG0   H31  H  N N 379 
PG0   H32  H  N N 380 
PG0   H21  H  N N 381 
PG0   H22  H  N N 382 
PG0   H11  H  N N 383 
PG0   H12  H  N N 384 
PG0   HTT  H  N N 385 
PHE   N    N  N N 386 
PHE   CA   C  N S 387 
PHE   C    C  N N 388 
PHE   O    O  N N 389 
PHE   CB   C  N N 390 
PHE   CG   C  Y N 391 
PHE   CD1  C  Y N 392 
PHE   CD2  C  Y N 393 
PHE   CE1  C  Y N 394 
PHE   CE2  C  Y N 395 
PHE   CZ   C  Y N 396 
PHE   OXT  O  N N 397 
PHE   H    H  N N 398 
PHE   H2   H  N N 399 
PHE   HA   H  N N 400 
PHE   HB2  H  N N 401 
PHE   HB3  H  N N 402 
PHE   HD1  H  N N 403 
PHE   HD2  H  N N 404 
PHE   HE1  H  N N 405 
PHE   HE2  H  N N 406 
PHE   HZ   H  N N 407 
PHE   HXT  H  N N 408 
PRO   N    N  N N 409 
PRO   CA   C  N S 410 
PRO   C    C  N N 411 
PRO   O    O  N N 412 
PRO   CB   C  N N 413 
PRO   CG   C  N N 414 
PRO   CD   C  N N 415 
PRO   OXT  O  N N 416 
PRO   H    H  N N 417 
PRO   HA   H  N N 418 
PRO   HB2  H  N N 419 
PRO   HB3  H  N N 420 
PRO   HG2  H  N N 421 
PRO   HG3  H  N N 422 
PRO   HD2  H  N N 423 
PRO   HD3  H  N N 424 
PRO   HXT  H  N N 425 
SER   N    N  N N 426 
SER   CA   C  N S 427 
SER   C    C  N N 428 
SER   O    O  N N 429 
SER   CB   C  N N 430 
SER   OG   O  N N 431 
SER   OXT  O  N N 432 
SER   H    H  N N 433 
SER   H2   H  N N 434 
SER   HA   H  N N 435 
SER   HB2  H  N N 436 
SER   HB3  H  N N 437 
SER   HG   H  N N 438 
SER   HXT  H  N N 439 
THR   N    N  N N 440 
THR   CA   C  N S 441 
THR   C    C  N N 442 
THR   O    O  N N 443 
THR   CB   C  N R 444 
THR   OG1  O  N N 445 
THR   CG2  C  N N 446 
THR   OXT  O  N N 447 
THR   H    H  N N 448 
THR   H2   H  N N 449 
THR   HA   H  N N 450 
THR   HB   H  N N 451 
THR   HG1  H  N N 452 
THR   HG21 H  N N 453 
THR   HG22 H  N N 454 
THR   HG23 H  N N 455 
THR   HXT  H  N N 456 
TRP   N    N  N N 457 
TRP   CA   C  N S 458 
TRP   C    C  N N 459 
TRP   O    O  N N 460 
TRP   CB   C  N N 461 
TRP   CG   C  Y N 462 
TRP   CD1  C  Y N 463 
TRP   CD2  C  Y N 464 
TRP   NE1  N  Y N 465 
TRP   CE2  C  Y N 466 
TRP   CE3  C  Y N 467 
TRP   CZ2  C  Y N 468 
TRP   CZ3  C  Y N 469 
TRP   CH2  C  Y N 470 
TRP   OXT  O  N N 471 
TRP   H    H  N N 472 
TRP   H2   H  N N 473 
TRP   HA   H  N N 474 
TRP   HB2  H  N N 475 
TRP   HB3  H  N N 476 
TRP   HD1  H  N N 477 
TRP   HE1  H  N N 478 
TRP   HE3  H  N N 479 
TRP   HZ2  H  N N 480 
TRP   HZ3  H  N N 481 
TRP   HH2  H  N N 482 
TRP   HXT  H  N N 483 
TYR   N    N  N N 484 
TYR   CA   C  N S 485 
TYR   C    C  N N 486 
TYR   O    O  N N 487 
TYR   CB   C  N N 488 
TYR   CG   C  Y N 489 
TYR   CD1  C  Y N 490 
TYR   CD2  C  Y N 491 
TYR   CE1  C  Y N 492 
TYR   CE2  C  Y N 493 
TYR   CZ   C  Y N 494 
TYR   OH   O  N N 495 
TYR   OXT  O  N N 496 
TYR   H    H  N N 497 
TYR   H2   H  N N 498 
TYR   HA   H  N N 499 
TYR   HB2  H  N N 500 
TYR   HB3  H  N N 501 
TYR   HD1  H  N N 502 
TYR   HD2  H  N N 503 
TYR   HE1  H  N N 504 
TYR   HE2  H  N N 505 
TYR   HH   H  N N 506 
TYR   HXT  H  N N 507 
VAL   N    N  N N 508 
VAL   CA   C  N S 509 
VAL   C    C  N N 510 
VAL   O    O  N N 511 
VAL   CB   C  N N 512 
VAL   CG1  C  N N 513 
VAL   CG2  C  N N 514 
VAL   OXT  O  N N 515 
VAL   H    H  N N 516 
VAL   H2   H  N N 517 
VAL   HA   H  N N 518 
VAL   HB   H  N N 519 
VAL   HG11 H  N N 520 
VAL   HG12 H  N N 521 
VAL   HG13 H  N N 522 
VAL   HG21 H  N N 523 
VAL   HG22 H  N N 524 
VAL   HG23 H  N N 525 
VAL   HXT  H  N N 526 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1ASU C04 C05  doub Y N 1   
A1ASU C04 C03  sing Y N 2   
A1ASU C05 C06  sing Y N 3   
A1ASU O02 C03  sing N N 4   
A1ASU O02 C01  sing N N 5   
A1ASU C03 C08  doub Y N 6   
A1ASU C10 C09  doub Y N 7   
A1ASU C10 N11  sing Y N 8   
A1ASU C06 C09  sing N N 9   
A1ASU C06 C07  doub Y N 10  
A1ASU C09 N13  sing Y N 11  
A1ASU N11 N12  doub Y N 12  
A1ASU C08 C07  sing Y N 13  
A1ASU N12 N13  sing Y N 14  
A1ASU N13 C14  sing N N 15  
A1ASU C19 C14  doub Y N 16  
A1ASU C19 C18  sing Y N 17  
A1ASU C14 C15  sing Y N 18  
A1ASU C18 C17  doub Y N 19  
A1ASU C15 C16  doub Y N 20  
A1ASU C17 C16  sing Y N 21  
A1ASU C17 C20  sing N N 22  
A1ASU C21 C20  doub Y N 23  
A1ASU C21 S22  sing Y N 24  
A1ASU C20 N25  sing Y N 25  
A1ASU S22 C23  sing Y N 26  
A1ASU N25 C23  doub Y N 27  
A1ASU C23 C24  sing N N 28  
A1ASU C01 H1   sing N N 29  
A1ASU C01 H2   sing N N 30  
A1ASU C01 H3   sing N N 31  
A1ASU C04 H4   sing N N 32  
A1ASU C05 H5   sing N N 33  
A1ASU C07 H6   sing N N 34  
A1ASU C08 H7   sing N N 35  
A1ASU C10 H8   sing N N 36  
A1ASU C15 H9   sing N N 37  
A1ASU C16 H10  sing N N 38  
A1ASU C18 H11  sing N N 39  
A1ASU C19 H12  sing N N 40  
A1ASU C21 H13  sing N N 41  
A1ASU C24 H14  sing N N 42  
A1ASU C24 H15  sing N N 43  
A1ASU C24 H16  sing N N 44  
ALA   N   CA   sing N N 45  
ALA   N   H    sing N N 46  
ALA   N   H2   sing N N 47  
ALA   CA  C    sing N N 48  
ALA   CA  CB   sing N N 49  
ALA   CA  HA   sing N N 50  
ALA   C   O    doub N N 51  
ALA   C   OXT  sing N N 52  
ALA   CB  HB1  sing N N 53  
ALA   CB  HB2  sing N N 54  
ALA   CB  HB3  sing N N 55  
ALA   OXT HXT  sing N N 56  
ARG   N   CA   sing N N 57  
ARG   N   H    sing N N 58  
ARG   N   H2   sing N N 59  
ARG   CA  C    sing N N 60  
ARG   CA  CB   sing N N 61  
ARG   CA  HA   sing N N 62  
ARG   C   O    doub N N 63  
ARG   C   OXT  sing N N 64  
ARG   CB  CG   sing N N 65  
ARG   CB  HB2  sing N N 66  
ARG   CB  HB3  sing N N 67  
ARG   CG  CD   sing N N 68  
ARG   CG  HG2  sing N N 69  
ARG   CG  HG3  sing N N 70  
ARG   CD  NE   sing N N 71  
ARG   CD  HD2  sing N N 72  
ARG   CD  HD3  sing N N 73  
ARG   NE  CZ   sing N N 74  
ARG   NE  HE   sing N N 75  
ARG   CZ  NH1  sing N N 76  
ARG   CZ  NH2  doub N N 77  
ARG   NH1 HH11 sing N N 78  
ARG   NH1 HH12 sing N N 79  
ARG   NH2 HH21 sing N N 80  
ARG   NH2 HH22 sing N N 81  
ARG   OXT HXT  sing N N 82  
ASN   N   CA   sing N N 83  
ASN   N   H    sing N N 84  
ASN   N   H2   sing N N 85  
ASN   CA  C    sing N N 86  
ASN   CA  CB   sing N N 87  
ASN   CA  HA   sing N N 88  
ASN   C   O    doub N N 89  
ASN   C   OXT  sing N N 90  
ASN   CB  CG   sing N N 91  
ASN   CB  HB2  sing N N 92  
ASN   CB  HB3  sing N N 93  
ASN   CG  OD1  doub N N 94  
ASN   CG  ND2  sing N N 95  
ASN   ND2 HD21 sing N N 96  
ASN   ND2 HD22 sing N N 97  
ASN   OXT HXT  sing N N 98  
ASP   N   CA   sing N N 99  
ASP   N   H    sing N N 100 
ASP   N   H2   sing N N 101 
ASP   CA  C    sing N N 102 
ASP   CA  CB   sing N N 103 
ASP   CA  HA   sing N N 104 
ASP   C   O    doub N N 105 
ASP   C   OXT  sing N N 106 
ASP   CB  CG   sing N N 107 
ASP   CB  HB2  sing N N 108 
ASP   CB  HB3  sing N N 109 
ASP   CG  OD1  doub N N 110 
ASP   CG  OD2  sing N N 111 
ASP   OD2 HD2  sing N N 112 
ASP   OXT HXT  sing N N 113 
CYS   N   CA   sing N N 114 
CYS   N   H    sing N N 115 
CYS   N   H2   sing N N 116 
CYS   CA  C    sing N N 117 
CYS   CA  CB   sing N N 118 
CYS   CA  HA   sing N N 119 
CYS   C   O    doub N N 120 
CYS   C   OXT  sing N N 121 
CYS   CB  SG   sing N N 122 
CYS   CB  HB2  sing N N 123 
CYS   CB  HB3  sing N N 124 
CYS   SG  HG   sing N N 125 
CYS   OXT HXT  sing N N 126 
GLN   N   CA   sing N N 127 
GLN   N   H    sing N N 128 
GLN   N   H2   sing N N 129 
GLN   CA  C    sing N N 130 
GLN   CA  CB   sing N N 131 
GLN   CA  HA   sing N N 132 
GLN   C   O    doub N N 133 
GLN   C   OXT  sing N N 134 
GLN   CB  CG   sing N N 135 
GLN   CB  HB2  sing N N 136 
GLN   CB  HB3  sing N N 137 
GLN   CG  CD   sing N N 138 
GLN   CG  HG2  sing N N 139 
GLN   CG  HG3  sing N N 140 
GLN   CD  OE1  doub N N 141 
GLN   CD  NE2  sing N N 142 
GLN   NE2 HE21 sing N N 143 
GLN   NE2 HE22 sing N N 144 
GLN   OXT HXT  sing N N 145 
GLU   N   CA   sing N N 146 
GLU   N   H    sing N N 147 
GLU   N   H2   sing N N 148 
GLU   CA  C    sing N N 149 
GLU   CA  CB   sing N N 150 
GLU   CA  HA   sing N N 151 
GLU   C   O    doub N N 152 
GLU   C   OXT  sing N N 153 
GLU   CB  CG   sing N N 154 
GLU   CB  HB2  sing N N 155 
GLU   CB  HB3  sing N N 156 
GLU   CG  CD   sing N N 157 
GLU   CG  HG2  sing N N 158 
GLU   CG  HG3  sing N N 159 
GLU   CD  OE1  doub N N 160 
GLU   CD  OE2  sing N N 161 
GLU   OE2 HE2  sing N N 162 
GLU   OXT HXT  sing N N 163 
GLY   N   CA   sing N N 164 
GLY   N   H    sing N N 165 
GLY   N   H2   sing N N 166 
GLY   CA  C    sing N N 167 
GLY   CA  HA2  sing N N 168 
GLY   CA  HA3  sing N N 169 
GLY   C   O    doub N N 170 
GLY   C   OXT  sing N N 171 
GLY   OXT HXT  sing N N 172 
HEM   CHA C1A  sing N N 173 
HEM   CHA C4D  doub N N 174 
HEM   CHA HHA  sing N N 175 
HEM   CHB C4A  sing N N 176 
HEM   CHB C1B  doub N N 177 
HEM   CHB HHB  sing N N 178 
HEM   CHC C4B  sing N N 179 
HEM   CHC C1C  doub N N 180 
HEM   CHC HHC  sing N N 181 
HEM   CHD C4C  doub N N 182 
HEM   CHD C1D  sing N N 183 
HEM   CHD HHD  sing N N 184 
HEM   C1A C2A  doub Y N 185 
HEM   C1A NA   sing Y N 186 
HEM   C2A C3A  sing Y N 187 
HEM   C2A CAA  sing N N 188 
HEM   C3A C4A  doub Y N 189 
HEM   C3A CMA  sing N N 190 
HEM   C4A NA   sing Y N 191 
HEM   CMA HMA  sing N N 192 
HEM   CMA HMAA sing N N 193 
HEM   CMA HMAB sing N N 194 
HEM   CAA CBA  sing N N 195 
HEM   CAA HAA  sing N N 196 
HEM   CAA HAAA sing N N 197 
HEM   CBA CGA  sing N N 198 
HEM   CBA HBA  sing N N 199 
HEM   CBA HBAA sing N N 200 
HEM   CGA O1A  doub N N 201 
HEM   CGA O2A  sing N N 202 
HEM   C1B C2B  sing N N 203 
HEM   C1B NB   sing N N 204 
HEM   C2B C3B  doub N N 205 
HEM   C2B CMB  sing N N 206 
HEM   C3B C4B  sing N N 207 
HEM   C3B CAB  sing N N 208 
HEM   C4B NB   doub N N 209 
HEM   CMB HMB  sing N N 210 
HEM   CMB HMBA sing N N 211 
HEM   CMB HMBB sing N N 212 
HEM   CAB CBB  doub N N 213 
HEM   CAB HAB  sing N N 214 
HEM   CBB HBB  sing N N 215 
HEM   CBB HBBA sing N N 216 
HEM   C1C C2C  sing Y N 217 
HEM   C1C NC   sing Y N 218 
HEM   C2C C3C  doub Y N 219 
HEM   C2C CMC  sing N N 220 
HEM   C3C C4C  sing Y N 221 
HEM   C3C CAC  sing N N 222 
HEM   C4C NC   sing Y N 223 
HEM   CMC HMC  sing N N 224 
HEM   CMC HMCA sing N N 225 
HEM   CMC HMCB sing N N 226 
HEM   CAC CBC  doub N N 227 
HEM   CAC HAC  sing N N 228 
HEM   CBC HBC  sing N N 229 
HEM   CBC HBCA sing N N 230 
HEM   C1D C2D  sing N N 231 
HEM   C1D ND   doub N N 232 
HEM   C2D C3D  doub N N 233 
HEM   C2D CMD  sing N N 234 
HEM   C3D C4D  sing N N 235 
HEM   C3D CAD  sing N N 236 
HEM   C4D ND   sing N N 237 
HEM   CMD HMD  sing N N 238 
HEM   CMD HMDA sing N N 239 
HEM   CMD HMDB sing N N 240 
HEM   CAD CBD  sing N N 241 
HEM   CAD HAD  sing N N 242 
HEM   CAD HADA sing N N 243 
HEM   CBD CGD  sing N N 244 
HEM   CBD HBD  sing N N 245 
HEM   CBD HBDA sing N N 246 
HEM   CGD O1D  doub N N 247 
HEM   CGD O2D  sing N N 248 
HEM   O2A H2A  sing N N 249 
HEM   O2D H2D  sing N N 250 
HEM   FE  NA   sing N N 251 
HEM   FE  NB   sing N N 252 
HEM   FE  NC   sing N N 253 
HEM   FE  ND   sing N N 254 
HIS   N   CA   sing N N 255 
HIS   N   H    sing N N 256 
HIS   N   H2   sing N N 257 
HIS   CA  C    sing N N 258 
HIS   CA  CB   sing N N 259 
HIS   CA  HA   sing N N 260 
HIS   C   O    doub N N 261 
HIS   C   OXT  sing N N 262 
HIS   CB  CG   sing N N 263 
HIS   CB  HB2  sing N N 264 
HIS   CB  HB3  sing N N 265 
HIS   CG  ND1  sing Y N 266 
HIS   CG  CD2  doub Y N 267 
HIS   ND1 CE1  doub Y N 268 
HIS   ND1 HD1  sing N N 269 
HIS   CD2 NE2  sing Y N 270 
HIS   CD2 HD2  sing N N 271 
HIS   CE1 NE2  sing Y N 272 
HIS   CE1 HE1  sing N N 273 
HIS   NE2 HE2  sing N N 274 
HIS   OXT HXT  sing N N 275 
HOH   O   H1   sing N N 276 
HOH   O   H2   sing N N 277 
ILE   N   CA   sing N N 278 
ILE   N   H    sing N N 279 
ILE   N   H2   sing N N 280 
ILE   CA  C    sing N N 281 
ILE   CA  CB   sing N N 282 
ILE   CA  HA   sing N N 283 
ILE   C   O    doub N N 284 
ILE   C   OXT  sing N N 285 
ILE   CB  CG1  sing N N 286 
ILE   CB  CG2  sing N N 287 
ILE   CB  HB   sing N N 288 
ILE   CG1 CD1  sing N N 289 
ILE   CG1 HG12 sing N N 290 
ILE   CG1 HG13 sing N N 291 
ILE   CG2 HG21 sing N N 292 
ILE   CG2 HG22 sing N N 293 
ILE   CG2 HG23 sing N N 294 
ILE   CD1 HD11 sing N N 295 
ILE   CD1 HD12 sing N N 296 
ILE   CD1 HD13 sing N N 297 
ILE   OXT HXT  sing N N 298 
LEU   N   CA   sing N N 299 
LEU   N   H    sing N N 300 
LEU   N   H2   sing N N 301 
LEU   CA  C    sing N N 302 
LEU   CA  CB   sing N N 303 
LEU   CA  HA   sing N N 304 
LEU   C   O    doub N N 305 
LEU   C   OXT  sing N N 306 
LEU   CB  CG   sing N N 307 
LEU   CB  HB2  sing N N 308 
LEU   CB  HB3  sing N N 309 
LEU   CG  CD1  sing N N 310 
LEU   CG  CD2  sing N N 311 
LEU   CG  HG   sing N N 312 
LEU   CD1 HD11 sing N N 313 
LEU   CD1 HD12 sing N N 314 
LEU   CD1 HD13 sing N N 315 
LEU   CD2 HD21 sing N N 316 
LEU   CD2 HD22 sing N N 317 
LEU   CD2 HD23 sing N N 318 
LEU   OXT HXT  sing N N 319 
LYS   N   CA   sing N N 320 
LYS   N   H    sing N N 321 
LYS   N   H2   sing N N 322 
LYS   CA  C    sing N N 323 
LYS   CA  CB   sing N N 324 
LYS   CA  HA   sing N N 325 
LYS   C   O    doub N N 326 
LYS   C   OXT  sing N N 327 
LYS   CB  CG   sing N N 328 
LYS   CB  HB2  sing N N 329 
LYS   CB  HB3  sing N N 330 
LYS   CG  CD   sing N N 331 
LYS   CG  HG2  sing N N 332 
LYS   CG  HG3  sing N N 333 
LYS   CD  CE   sing N N 334 
LYS   CD  HD2  sing N N 335 
LYS   CD  HD3  sing N N 336 
LYS   CE  NZ   sing N N 337 
LYS   CE  HE2  sing N N 338 
LYS   CE  HE3  sing N N 339 
LYS   NZ  HZ1  sing N N 340 
LYS   NZ  HZ2  sing N N 341 
LYS   NZ  HZ3  sing N N 342 
LYS   OXT HXT  sing N N 343 
MET   N   CA   sing N N 344 
MET   N   H    sing N N 345 
MET   N   H2   sing N N 346 
MET   CA  C    sing N N 347 
MET   CA  CB   sing N N 348 
MET   CA  HA   sing N N 349 
MET   C   O    doub N N 350 
MET   C   OXT  sing N N 351 
MET   CB  CG   sing N N 352 
MET   CB  HB2  sing N N 353 
MET   CB  HB3  sing N N 354 
MET   CG  SD   sing N N 355 
MET   CG  HG2  sing N N 356 
MET   CG  HG3  sing N N 357 
MET   SD  CE   sing N N 358 
MET   CE  HE1  sing N N 359 
MET   CE  HE2  sing N N 360 
MET   CE  HE3  sing N N 361 
MET   OXT HXT  sing N N 362 
PG0   C5  O2   sing N N 363 
PG0   C5  H51  sing N N 364 
PG0   C5  H52  sing N N 365 
PG0   C5  H53  sing N N 366 
PG0   O2  C4   sing N N 367 
PG0   C4  C3   sing N N 368 
PG0   C4  H41  sing N N 369 
PG0   C4  H42  sing N N 370 
PG0   C3  O1   sing N N 371 
PG0   C3  H31  sing N N 372 
PG0   C3  H32  sing N N 373 
PG0   O1  C2   sing N N 374 
PG0   C2  C1   sing N N 375 
PG0   C2  H21  sing N N 376 
PG0   C2  H22  sing N N 377 
PG0   C1  OTT  sing N N 378 
PG0   C1  H11  sing N N 379 
PG0   C1  H12  sing N N 380 
PG0   OTT HTT  sing N N 381 
PHE   N   CA   sing N N 382 
PHE   N   H    sing N N 383 
PHE   N   H2   sing N N 384 
PHE   CA  C    sing N N 385 
PHE   CA  CB   sing N N 386 
PHE   CA  HA   sing N N 387 
PHE   C   O    doub N N 388 
PHE   C   OXT  sing N N 389 
PHE   CB  CG   sing N N 390 
PHE   CB  HB2  sing N N 391 
PHE   CB  HB3  sing N N 392 
PHE   CG  CD1  doub Y N 393 
PHE   CG  CD2  sing Y N 394 
PHE   CD1 CE1  sing Y N 395 
PHE   CD1 HD1  sing N N 396 
PHE   CD2 CE2  doub Y N 397 
PHE   CD2 HD2  sing N N 398 
PHE   CE1 CZ   doub Y N 399 
PHE   CE1 HE1  sing N N 400 
PHE   CE2 CZ   sing Y N 401 
PHE   CE2 HE2  sing N N 402 
PHE   CZ  HZ   sing N N 403 
PHE   OXT HXT  sing N N 404 
PRO   N   CA   sing N N 405 
PRO   N   CD   sing N N 406 
PRO   N   H    sing N N 407 
PRO   CA  C    sing N N 408 
PRO   CA  CB   sing N N 409 
PRO   CA  HA   sing N N 410 
PRO   C   O    doub N N 411 
PRO   C   OXT  sing N N 412 
PRO   CB  CG   sing N N 413 
PRO   CB  HB2  sing N N 414 
PRO   CB  HB3  sing N N 415 
PRO   CG  CD   sing N N 416 
PRO   CG  HG2  sing N N 417 
PRO   CG  HG3  sing N N 418 
PRO   CD  HD2  sing N N 419 
PRO   CD  HD3  sing N N 420 
PRO   OXT HXT  sing N N 421 
SER   N   CA   sing N N 422 
SER   N   H    sing N N 423 
SER   N   H2   sing N N 424 
SER   CA  C    sing N N 425 
SER   CA  CB   sing N N 426 
SER   CA  HA   sing N N 427 
SER   C   O    doub N N 428 
SER   C   OXT  sing N N 429 
SER   CB  OG   sing N N 430 
SER   CB  HB2  sing N N 431 
SER   CB  HB3  sing N N 432 
SER   OG  HG   sing N N 433 
SER   OXT HXT  sing N N 434 
THR   N   CA   sing N N 435 
THR   N   H    sing N N 436 
THR   N   H2   sing N N 437 
THR   CA  C    sing N N 438 
THR   CA  CB   sing N N 439 
THR   CA  HA   sing N N 440 
THR   C   O    doub N N 441 
THR   C   OXT  sing N N 442 
THR   CB  OG1  sing N N 443 
THR   CB  CG2  sing N N 444 
THR   CB  HB   sing N N 445 
THR   OG1 HG1  sing N N 446 
THR   CG2 HG21 sing N N 447 
THR   CG2 HG22 sing N N 448 
THR   CG2 HG23 sing N N 449 
THR   OXT HXT  sing N N 450 
TRP   N   CA   sing N N 451 
TRP   N   H    sing N N 452 
TRP   N   H2   sing N N 453 
TRP   CA  C    sing N N 454 
TRP   CA  CB   sing N N 455 
TRP   CA  HA   sing N N 456 
TRP   C   O    doub N N 457 
TRP   C   OXT  sing N N 458 
TRP   CB  CG   sing N N 459 
TRP   CB  HB2  sing N N 460 
TRP   CB  HB3  sing N N 461 
TRP   CG  CD1  doub Y N 462 
TRP   CG  CD2  sing Y N 463 
TRP   CD1 NE1  sing Y N 464 
TRP   CD1 HD1  sing N N 465 
TRP   CD2 CE2  doub Y N 466 
TRP   CD2 CE3  sing Y N 467 
TRP   NE1 CE2  sing Y N 468 
TRP   NE1 HE1  sing N N 469 
TRP   CE2 CZ2  sing Y N 470 
TRP   CE3 CZ3  doub Y N 471 
TRP   CE3 HE3  sing N N 472 
TRP   CZ2 CH2  doub Y N 473 
TRP   CZ2 HZ2  sing N N 474 
TRP   CZ3 CH2  sing Y N 475 
TRP   CZ3 HZ3  sing N N 476 
TRP   CH2 HH2  sing N N 477 
TRP   OXT HXT  sing N N 478 
TYR   N   CA   sing N N 479 
TYR   N   H    sing N N 480 
TYR   N   H2   sing N N 481 
TYR   CA  C    sing N N 482 
TYR   CA  CB   sing N N 483 
TYR   CA  HA   sing N N 484 
TYR   C   O    doub N N 485 
TYR   C   OXT  sing N N 486 
TYR   CB  CG   sing N N 487 
TYR   CB  HB2  sing N N 488 
TYR   CB  HB3  sing N N 489 
TYR   CG  CD1  doub Y N 490 
TYR   CG  CD2  sing Y N 491 
TYR   CD1 CE1  sing Y N 492 
TYR   CD1 HD1  sing N N 493 
TYR   CD2 CE2  doub Y N 494 
TYR   CD2 HD2  sing N N 495 
TYR   CE1 CZ   doub Y N 496 
TYR   CE1 HE1  sing N N 497 
TYR   CE2 CZ   sing Y N 498 
TYR   CE2 HE2  sing N N 499 
TYR   CZ  OH   sing N N 500 
TYR   OH  HH   sing N N 501 
TYR   OXT HXT  sing N N 502 
VAL   N   CA   sing N N 503 
VAL   N   H    sing N N 504 
VAL   N   H2   sing N N 505 
VAL   CA  C    sing N N 506 
VAL   CA  CB   sing N N 507 
VAL   CA  HA   sing N N 508 
VAL   C   O    doub N N 509 
VAL   C   OXT  sing N N 510 
VAL   CB  CG1  sing N N 511 
VAL   CB  CG2  sing N N 512 
VAL   CB  HB   sing N N 513 
VAL   CG1 HG11 sing N N 514 
VAL   CG1 HG12 sing N N 515 
VAL   CG1 HG13 sing N N 516 
VAL   CG2 HG21 sing N N 517 
VAL   CG2 HG22 sing N N 518 
VAL   CG2 HG23 sing N N 519 
VAL   OXT HXT  sing N N 520 
# 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           R35GM118041 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   1TQN 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9BV6 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.013179 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.009931 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.008124 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
FE 
N  
O  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . SER   A 1 8   ? -26.762 7.717   -14.284 1.00 96.68  ? 29  SER   A N   1 
ATOM   2    C  CA  . SER   A 1 8   ? -25.412 7.363   -14.708 1.00 95.22  ? 29  SER   A CA  1 
ATOM   3    C  C   . SER   A 1 8   ? -25.432 6.617   -16.038 1.00 93.60  ? 29  SER   A C   1 
ATOM   4    O  O   . SER   A 1 8   ? -24.566 5.786   -16.307 1.00 90.25  ? 29  SER   A O   1 
ATOM   5    C  CB  . SER   A 1 8   ? -24.720 6.513   -13.640 1.00 93.38  ? 29  SER   A CB  1 
ATOM   6    O  OG  . SER   A 1 8   ? -25.440 5.317   -13.396 1.00 91.90  ? 29  SER   A OG  1 
ATOM   7    N  N   . HIS   A 1 9   ? -26.429 6.919   -16.869 1.00 93.37  ? 30  HIS   A N   1 
ATOM   8    C  CA  . HIS   A 1 9   ? -26.578 6.257   -18.159 1.00 88.96  ? 30  HIS   A CA  1 
ATOM   9    C  C   . HIS   A 1 9   ? -25.734 6.888   -19.258 1.00 88.49  ? 30  HIS   A C   1 
ATOM   10   O  O   . HIS   A 1 9   ? -25.732 6.375   -20.383 1.00 89.74  ? 30  HIS   A O   1 
ATOM   11   C  CB  . HIS   A 1 9   ? -28.050 6.248   -18.579 1.00 87.71  ? 30  HIS   A CB  1 
ATOM   12   C  CG  . HIS   A 1 9   ? -28.878 5.233   -17.854 1.00 93.21  ? 30  HIS   A CG  1 
ATOM   13   N  ND1 . HIS   A 1 9   ? -30.240 5.118   -18.032 1.00 97.31  ? 30  HIS   A ND1 1 
ATOM   14   C  CD2 . HIS   A 1 9   ? -28.535 4.283   -16.952 1.00 90.97  ? 30  HIS   A CD2 1 
ATOM   15   C  CE1 . HIS   A 1 9   ? -30.701 4.142   -17.270 1.00 94.94  ? 30  HIS   A CE1 1 
ATOM   16   N  NE2 . HIS   A 1 9   ? -29.686 3.619   -16.605 1.00 88.89  ? 30  HIS   A NE2 1 
ATOM   17   N  N   . GLY   A 1 10  ? -25.026 7.976   -18.970 1.00 89.00  ? 31  GLY   A N   1 
ATOM   18   C  CA  . GLY   A 1 10  ? -24.137 8.608   -19.921 1.00 85.60  ? 31  GLY   A CA  1 
ATOM   19   C  C   . GLY   A 1 10  ? -22.668 8.307   -19.725 1.00 89.76  ? 31  GLY   A C   1 
ATOM   20   O  O   . GLY   A 1 10  ? -21.828 9.006   -20.305 1.00 90.96  ? 31  GLY   A O   1 
ATOM   21   N  N   . LEU   A 1 11  ? -22.326 7.289   -18.932 1.00 88.90  ? 32  LEU   A N   1 
ATOM   22   C  CA  . LEU   A 1 11  ? -20.924 7.005   -18.638 1.00 86.14  ? 32  LEU   A CA  1 
ATOM   23   C  C   . LEU   A 1 11  ? -20.180 6.550   -19.888 1.00 90.55  ? 32  LEU   A C   1 
ATOM   24   O  O   . LEU   A 1 11  ? -19.210 7.187   -20.315 1.00 93.54  ? 32  LEU   A O   1 
ATOM   25   C  CB  . LEU   A 1 11  ? -20.830 5.952   -17.530 1.00 85.90  ? 32  LEU   A CB  1 
ATOM   26   C  CG  . LEU   A 1 11  ? -19.448 5.579   -16.986 1.00 84.64  ? 32  LEU   A CG  1 
ATOM   27   C  CD1 . LEU   A 1 11  ? -19.539 5.268   -15.503 1.00 83.67  ? 32  LEU   A CD1 1 
ATOM   28   C  CD2 . LEU   A 1 11  ? -18.860 4.389   -17.731 1.00 84.19  ? 32  LEU   A CD2 1 
ATOM   29   N  N   . PHE   A 1 12  ? -20.624 5.446   -20.493 1.00 88.60  ? 33  PHE   A N   1 
ATOM   30   C  CA  . PHE   A 1 12  ? -19.952 4.931   -21.680 1.00 88.31  ? 33  PHE   A CA  1 
ATOM   31   C  C   . PHE   A 1 12  ? -20.085 5.870   -22.872 1.00 89.99  ? 33  PHE   A C   1 
ATOM   32   O  O   . PHE   A 1 12  ? -19.282 5.781   -23.808 1.00 91.36  ? 33  PHE   A O   1 
ATOM   33   C  CB  . PHE   A 1 12  ? -20.492 3.544   -22.030 1.00 86.23  ? 33  PHE   A CB  1 
ATOM   34   C  CG  . PHE   A 1 12  ? -20.272 2.523   -20.949 1.00 84.32  ? 33  PHE   A CG  1 
ATOM   35   C  CD1 . PHE   A 1 12  ? -18.990 2.129   -20.604 1.00 83.59  ? 33  PHE   A CD1 1 
ATOM   36   C  CD2 . PHE   A 1 12  ? -21.345 1.957   -20.279 1.00 82.79  ? 33  PHE   A CD2 1 
ATOM   37   C  CE1 . PHE   A 1 12  ? -18.780 1.192   -19.609 1.00 81.48  ? 33  PHE   A CE1 1 
ATOM   38   C  CE2 . PHE   A 1 12  ? -21.141 1.017   -19.284 1.00 80.36  ? 33  PHE   A CE2 1 
ATOM   39   C  CZ  . PHE   A 1 12  ? -19.857 0.634   -18.948 1.00 79.59  ? 33  PHE   A CZ  1 
ATOM   40   N  N   . LYS   A 1 13  ? -21.078 6.761   -22.863 1.00 91.68  ? 34  LYS   A N   1 
ATOM   41   C  CA  . LYS   A 1 13  ? -21.161 7.781   -23.902 1.00 91.14  ? 34  LYS   A CA  1 
ATOM   42   C  C   . LYS   A 1 13  ? -20.048 8.811   -23.749 1.00 90.95  ? 34  LYS   A C   1 
ATOM   43   O  O   . LYS   A 1 13  ? -19.460 9.250   -24.744 1.00 93.13  ? 34  LYS   A O   1 
ATOM   44   C  CB  . LYS   A 1 13  ? -22.530 8.460   -23.867 1.00 89.61  ? 34  LYS   A CB  1 
ATOM   45   N  N   . LYS   A 1 14  ? -19.748 9.210   -22.510 1.00 91.83  ? 35  LYS   A N   1 
ATOM   46   C  CA  . LYS   A 1 14  ? -18.687 10.184  -22.281 1.00 92.45  ? 35  LYS   A CA  1 
ATOM   47   C  C   . LYS   A 1 14  ? -17.305 9.574   -22.478 1.00 94.35  ? 35  LYS   A C   1 
ATOM   48   O  O   . LYS   A 1 14  ? -16.367 10.280  -22.866 1.00 98.41  ? 35  LYS   A O   1 
ATOM   49   C  CB  . LYS   A 1 14  ? -18.807 10.772  -20.875 1.00 87.58  ? 35  LYS   A CB  1 
ATOM   50   N  N   . LEU   A 1 15  ? -17.157 8.276   -22.217 1.00 93.09  ? 36  LEU   A N   1 
ATOM   51   C  CA  . LEU   A 1 15  ? -15.872 7.606   -22.371 1.00 90.78  ? 36  LEU   A CA  1 
ATOM   52   C  C   . LEU   A 1 15  ? -15.567 7.218   -23.811 1.00 92.57  ? 36  LEU   A C   1 
ATOM   53   O  O   . LEU   A 1 15  ? -14.464 6.731   -24.081 1.00 96.99  ? 36  LEU   A O   1 
ATOM   54   C  CB  . LEU   A 1 15  ? -15.819 6.353   -21.491 1.00 93.64  ? 36  LEU   A CB  1 
ATOM   55   C  CG  . LEU   A 1 15  ? -15.522 6.544   -20.004 1.00 93.75  ? 36  LEU   A CG  1 
ATOM   56   C  CD1 . LEU   A 1 15  ? -15.577 5.208   -19.279 1.00 91.67  ? 36  LEU   A CD1 1 
ATOM   57   C  CD2 . LEU   A 1 15  ? -14.163 7.198   -19.817 1.00 94.48  ? 36  LEU   A CD2 1 
ATOM   58   N  N   . GLY   A 1 16  ? -16.502 7.418   -24.732 1.00 90.06  ? 37  GLY   A N   1 
ATOM   59   C  CA  . GLY   A 1 16  ? -16.307 6.960   -26.096 1.00 88.65  ? 37  GLY   A CA  1 
ATOM   60   C  C   . GLY   A 1 16  ? -16.264 5.453   -26.222 1.00 89.21  ? 37  GLY   A C   1 
ATOM   61   O  O   . GLY   A 1 16  ? -15.460 4.921   -26.997 1.00 91.44  ? 37  GLY   A O   1 
ATOM   62   N  N   . ILE   A 1 17  ? -17.106 4.755   -25.476 1.00 88.32  ? 38  ILE   A N   1 
ATOM   63   C  CA  . ILE   A 1 17  ? -17.164 3.294   -25.470 1.00 88.58  ? 38  ILE   A CA  1 
ATOM   64   C  C   . ILE   A 1 17  ? -18.498 2.871   -26.070 1.00 85.22  ? 38  ILE   A C   1 
ATOM   65   O  O   . ILE   A 1 17  ? -19.546 3.338   -25.609 1.00 87.79  ? 38  ILE   A O   1 
ATOM   66   C  CB  . ILE   A 1 17  ? -16.999 2.721   -24.050 1.00 89.63  ? 38  ILE   A CB  1 
ATOM   67   C  CG1 . ILE   A 1 17  ? -15.557 2.905   -23.569 1.00 88.19  ? 38  ILE   A CG1 1 
ATOM   68   C  CG2 . ILE   A 1 17  ? -17.412 1.255   -24.005 1.00 85.60  ? 38  ILE   A CG2 1 
ATOM   69   C  CD1 . ILE   A 1 17  ? -15.322 2.442   -22.151 1.00 86.76  ? 38  ILE   A CD1 1 
ATOM   70   N  N   . PRO   A 1 18  ? -18.509 2.007   -27.081 1.00 82.62  ? 39  PRO   A N   1 
ATOM   71   C  CA  . PRO   A 1 18  ? -19.773 1.630   -27.723 1.00 86.07  ? 39  PRO   A CA  1 
ATOM   72   C  C   . PRO   A 1 18  ? -20.603 0.717   -26.833 1.00 84.08  ? 39  PRO   A C   1 
ATOM   73   O  O   . PRO   A 1 18  ? -20.158 0.226   -25.794 1.00 86.21  ? 39  PRO   A O   1 
ATOM   74   C  CB  . PRO   A 1 18  ? -19.321 0.910   -28.996 1.00 83.81  ? 39  PRO   A CB  1 
ATOM   75   C  CG  . PRO   A 1 18  ? -17.984 0.350   -28.643 1.00 80.69  ? 39  PRO   A CG  1 
ATOM   76   C  CD  . PRO   A 1 18  ? -17.350 1.347   -27.707 1.00 85.75  ? 39  PRO   A CD  1 
ATOM   77   N  N   . GLY   A 1 19  ? -21.843 0.498   -27.261 1.00 84.25  ? 40  GLY   A N   1 
ATOM   78   C  CA  . GLY   A 1 19  ? -22.750 -0.379  -26.562 1.00 84.99  ? 40  GLY   A CA  1 
ATOM   79   C  C   . GLY   A 1 19  ? -24.197 -0.099  -26.907 1.00 86.20  ? 40  GLY   A C   1 
ATOM   80   O  O   . GLY   A 1 19  ? -24.531 0.933   -27.498 1.00 85.68  ? 40  GLY   A O   1 
ATOM   81   N  N   . PRO   A 1 20  ? -25.089 -1.024  -26.552 1.00 85.20  ? 41  PRO   A N   1 
ATOM   82   C  CA  . PRO   A 1 20  ? -26.515 -0.805  -26.814 1.00 86.06  ? 41  PRO   A CA  1 
ATOM   83   C  C   . PRO   A 1 20  ? -27.049 0.366   -26.005 1.00 87.75  ? 41  PRO   A C   1 
ATOM   84   O  O   . PRO   A 1 20  ? -26.627 0.614   -24.873 1.00 86.17  ? 41  PRO   A O   1 
ATOM   85   C  CB  . PRO   A 1 20  ? -27.162 -2.127  -26.388 1.00 82.59  ? 41  PRO   A CB  1 
ATOM   86   C  CG  . PRO   A 1 20  ? -26.211 -2.706  -25.397 1.00 81.98  ? 41  PRO   A CG  1 
ATOM   87   C  CD  . PRO   A 1 20  ? -24.840 -2.299  -25.859 1.00 82.45  ? 41  PRO   A CD  1 
ATOM   88   N  N   . THR   A 1 21  ? -27.990 1.086   -26.599 1.00 89.68  ? 42  THR   A N   1 
ATOM   89   C  CA  . THR   A 1 21  ? -28.567 2.250   -25.940 1.00 87.95  ? 42  THR   A CA  1 
ATOM   90   C  C   . THR   A 1 21  ? -29.466 1.801   -24.796 1.00 86.18  ? 42  THR   A C   1 
ATOM   91   O  O   . THR   A 1 21  ? -30.431 1.061   -25.032 1.00 86.82  ? 42  THR   A O   1 
ATOM   92   C  CB  . THR   A 1 21  ? -29.356 3.095   -26.935 1.00 87.11  ? 42  THR   A CB  1 
ATOM   93   O  OG1 . THR   A 1 21  ? -28.476 3.569   -27.962 1.00 92.08  ? 42  THR   A OG1 1 
ATOM   94   C  CG2 . THR   A 1 21  ? -29.989 4.284   -26.230 1.00 85.19  ? 42  THR   A CG2 1 
ATOM   95   N  N   . PRO   A 1 22  ? -29.201 2.217   -23.563 1.00 83.49  ? 43  PRO   A N   1 
ATOM   96   C  CA  . PRO   A 1 22  ? -29.987 1.728   -22.430 1.00 85.54  ? 43  PRO   A CA  1 
ATOM   97   C  C   . PRO   A 1 22  ? -31.267 2.521   -22.226 1.00 84.43  ? 43  PRO   A C   1 
ATOM   98   O  O   . PRO   A 1 22  ? -31.355 3.710   -22.543 1.00 82.53  ? 43  PRO   A O   1 
ATOM   99   C  CB  . PRO   A 1 22  ? -29.033 1.917   -21.246 1.00 86.36  ? 43  PRO   A CB  1 
ATOM   100  C  CG  . PRO   A 1 22  ? -28.244 3.128   -21.625 1.00 84.01  ? 43  PRO   A CG  1 
ATOM   101  C  CD  . PRO   A 1 22  ? -28.088 3.081   -23.131 1.00 83.08  ? 43  PRO   A CD  1 
ATOM   102  N  N   . LEU   A 1 23  ? -32.272 1.832   -21.681 1.00 82.05  ? 44  LEU   A N   1 
ATOM   103  C  CA  . LEU   A 1 23  ? -33.533 2.442   -21.293 1.00 83.36  ? 44  LEU   A CA  1 
ATOM   104  C  C   . LEU   A 1 23  ? -33.473 2.901   -19.839 1.00 86.12  ? 44  LEU   A C   1 
ATOM   105  O  O   . LEU   A 1 23  ? -32.717 2.342   -19.037 1.00 87.92  ? 44  LEU   A O   1 
ATOM   106  C  CB  . LEU   A 1 23  ? -34.679 1.452   -21.476 1.00 83.37  ? 44  LEU   A CB  1 
ATOM   107  C  CG  . LEU   A 1 23  ? -34.908 0.978   -22.912 1.00 83.56  ? 44  LEU   A CG  1 
ATOM   108  C  CD1 . LEU   A 1 23  ? -36.102 0.045   -22.982 1.00 81.37  ? 44  LEU   A CD1 1 
ATOM   109  C  CD2 . LEU   A 1 23  ? -35.094 2.164   -23.846 1.00 87.88  ? 44  LEU   A CD2 1 
ATOM   110  N  N   . PRO   A 1 24  ? -34.244 3.926   -19.474 1.00 86.43  ? 45  PRO   A N   1 
ATOM   111  C  CA  . PRO   A 1 24  ? -34.202 4.421   -18.092 1.00 89.19  ? 45  PRO   A CA  1 
ATOM   112  C  C   . PRO   A 1 24  ? -34.618 3.352   -17.091 1.00 88.03  ? 45  PRO   A C   1 
ATOM   113  O  O   . PRO   A 1 24  ? -35.558 2.588   -17.322 1.00 89.25  ? 45  PRO   A O   1 
ATOM   114  C  CB  . PRO   A 1 24  ? -35.191 5.593   -18.106 1.00 90.85  ? 45  PRO   A CB  1 
ATOM   115  C  CG  . PRO   A 1 24  ? -35.246 6.022   -19.535 1.00 85.87  ? 45  PRO   A CG  1 
ATOM   116  C  CD  . PRO   A 1 24  ? -35.091 4.767   -20.338 1.00 83.73  ? 45  PRO   A CD  1 
ATOM   117  N  N   . PHE   A 1 25  ? -33.871 3.287   -15.985 1.00 88.69  ? 46  PHE   A N   1 
ATOM   118  C  CA  . PHE   A 1 25  ? -34.154 2.436   -14.829 1.00 90.06  ? 46  PHE   A CA  1 
ATOM   119  C  C   . PHE   A 1 25  ? -33.940 0.957   -15.129 1.00 90.14  ? 46  PHE   A C   1 
ATOM   120  O  O   . PHE   A 1 25  ? -33.962 0.128   -14.215 1.00 96.26  ? 46  PHE   A O   1 
ATOM   121  C  CB  . PHE   A 1 25  ? -35.583 2.649   -14.319 1.00 88.76  ? 46  PHE   A CB  1 
ATOM   122  C  CG  . PHE   A 1 25  ? -35.923 4.082   -14.037 1.00 96.80  ? 46  PHE   A CG  1 
ATOM   123  C  CD1 . PHE   A 1 25  ? -35.421 4.721   -12.916 1.00 99.06  ? 46  PHE   A CD1 1 
ATOM   124  C  CD2 . PHE   A 1 25  ? -36.758 4.787   -14.887 1.00 101.64 ? 46  PHE   A CD2 1 
ATOM   125  C  CE1 . PHE   A 1 25  ? -35.738 6.042   -12.654 1.00 101.95 ? 46  PHE   A CE1 1 
ATOM   126  C  CE2 . PHE   A 1 25  ? -37.080 6.106   -14.632 1.00 101.84 ? 46  PHE   A CE2 1 
ATOM   127  C  CZ  . PHE   A 1 25  ? -36.569 6.735   -13.513 1.00 104.30 ? 46  PHE   A CZ  1 
ATOM   128  N  N   . LEU   A 1 26  ? -33.705 0.616   -16.396 1.00 87.85  ? 47  LEU   A N   1 
ATOM   129  C  CA  . LEU   A 1 26  ? -33.540 -0.769  -16.805 1.00 85.25  ? 47  LEU   A CA  1 
ATOM   130  C  C   . LEU   A 1 26  ? -32.187 -1.071  -17.422 1.00 82.16  ? 47  LEU   A C   1 
ATOM   131  O  O   . LEU   A 1 26  ? -31.784 -2.239  -17.431 1.00 83.38  ? 47  LEU   A O   1 
ATOM   132  C  CB  . LEU   A 1 26  ? -34.628 -1.171  -17.816 1.00 87.43  ? 47  LEU   A CB  1 
ATOM   133  C  CG  . LEU   A 1 26  ? -36.092 -1.176  -17.373 1.00 87.60  ? 47  LEU   A CG  1 
ATOM   134  C  CD1 . LEU   A 1 26  ? -36.988 -1.586  -18.531 1.00 86.12  ? 47  LEU   A CD1 1 
ATOM   135  C  CD2 . LEU   A 1 26  ? -36.304 -2.101  -16.186 1.00 89.31  ? 47  LEU   A CD2 1 
ATOM   136  N  N   . GLY   A 1 27  ? -31.477 -0.069  -17.925 1.00 83.46  ? 48  GLY   A N   1 
ATOM   137  C  CA  . GLY   A 1 27  ? -30.243 -0.345  -18.637 1.00 84.41  ? 48  GLY   A CA  1 
ATOM   138  C  C   . GLY   A 1 27  ? -30.530 -1.119  -19.907 1.00 85.19  ? 48  GLY   A C   1 
ATOM   139  O  O   . GLY   A 1 27  ? -31.362 -0.719  -20.730 1.00 87.35  ? 48  GLY   A O   1 
ATOM   140  N  N   . ASN   A 1 28  ? -29.841 -2.249  -20.074 1.00 83.22  ? 49  ASN   A N   1 
ATOM   141  C  CA  . ASN   A 1 28  ? -30.000 -3.097  -21.250 1.00 81.47  ? 49  ASN   A CA  1 
ATOM   142  C  C   . ASN   A 1 28  ? -30.497 -4.493  -20.888 1.00 85.71  ? 49  ASN   A C   1 
ATOM   143  O  O   . ASN   A 1 28  ? -30.281 -5.441  -21.651 1.00 85.96  ? 49  ASN   A O   1 
ATOM   144  C  CB  . ASN   A 1 28  ? -28.682 -3.188  -22.023 1.00 82.16  ? 49  ASN   A CB  1 
ATOM   145  C  CG  . ASN   A 1 28  ? -28.110 -1.825  -22.363 1.00 81.70  ? 49  ASN   A CG  1 
ATOM   146  O  OD1 . ASN   A 1 28  ? -27.296 -1.277  -21.619 1.00 78.87  ? 49  ASN   A OD1 1 
ATOM   147  N  ND2 . ASN   A 1 28  ? -28.537 -1.268  -23.489 1.00 86.33  ? 49  ASN   A ND2 1 
ATOM   148  N  N   . ILE   A 1 29  ? -31.164 -4.639  -19.739 1.00 85.78  ? 50  ILE   A N   1 
ATOM   149  C  CA  . ILE   A 1 29  ? -31.594 -5.958  -19.288 1.00 84.91  ? 50  ILE   A CA  1 
ATOM   150  C  C   . ILE   A 1 29  ? -32.675 -6.549  -20.182 1.00 83.95  ? 50  ILE   A C   1 
ATOM   151  O  O   . ILE   A 1 29  ? -32.859 -7.771  -20.191 1.00 86.43  ? 50  ILE   A O   1 
ATOM   152  C  CB  . ILE   A 1 29  ? -32.085 -5.906  -17.830 1.00 83.28  ? 50  ILE   A CB  1 
ATOM   153  C  CG1 . ILE   A 1 29  ? -33.386 -5.108  -17.735 1.00 83.20  ? 50  ILE   A CG1 1 
ATOM   154  C  CG2 . ILE   A 1 29  ? -31.008 -5.316  -16.930 1.00 84.89  ? 50  ILE   A CG2 1 
ATOM   155  C  CD1 . ILE   A 1 29  ? -34.284 -5.540  -16.603 1.00 87.73  ? 50  ILE   A CD1 1 
ATOM   156  N  N   . LEU   A 1 30  ? -33.404 -5.720  -20.935 1.00 84.04  ? 51  LEU   A N   1 
ATOM   157  C  CA  . LEU   A 1 30  ? -34.368 -6.257  -21.888 1.00 84.67  ? 51  LEU   A CA  1 
ATOM   158  C  C   . LEU   A 1 30  ? -33.693 -7.090  -22.966 1.00 88.27  ? 51  LEU   A C   1 
ATOM   159  O  O   . LEU   A 1 30  ? -34.337 -7.966  -23.553 1.00 90.60  ? 51  LEU   A O   1 
ATOM   160  C  CB  . LEU   A 1 30  ? -35.172 -5.127  -22.534 1.00 83.77  ? 51  LEU   A CB  1 
ATOM   161  C  CG  . LEU   A 1 30  ? -36.154 -4.375  -21.634 1.00 86.94  ? 51  LEU   A CG  1 
ATOM   162  C  CD1 . LEU   A 1 30  ? -37.057 -3.478  -22.467 1.00 86.06  ? 51  LEU   A CD1 1 
ATOM   163  C  CD2 . LEU   A 1 30  ? -36.976 -5.346  -20.799 1.00 81.75  ? 51  LEU   A CD2 1 
ATOM   164  N  N   . SER   A 1 31  ? -32.412 -6.841  -23.234 1.00 88.16  ? 52  SER   A N   1 
ATOM   165  C  CA  . SER   A 1 31  ? -31.658 -7.632  -24.195 1.00 87.21  ? 52  SER   A CA  1 
ATOM   166  C  C   . SER   A 1 31  ? -31.259 -8.997  -23.650 1.00 87.55  ? 52  SER   A C   1 
ATOM   167  O  O   . SER   A 1 31  ? -30.704 -9.806  -24.401 1.00 91.22  ? 52  SER   A O   1 
ATOM   168  C  CB  . SER   A 1 31  ? -30.411 -6.867  -24.642 1.00 85.37  ? 52  SER   A CB  1 
ATOM   169  O  OG  . SER   A 1 31  ? -30.754 -5.608  -25.192 1.00 83.66  ? 52  SER   A OG  1 
ATOM   170  N  N   . TYR   A 1 32  ? -31.513 -9.265  -22.370 1.00 87.27  ? 53  TYR   A N   1 
ATOM   171  C  CA  . TYR   A 1 32  ? -31.275 -10.578 -21.783 1.00 89.57  ? 53  TYR   A CA  1 
ATOM   172  C  C   . TYR   A 1 32  ? -32.344 -11.598 -22.156 1.00 92.45  ? 53  TYR   A C   1 
ATOM   173  O  O   . TYR   A 1 32  ? -32.302 -12.724 -21.649 1.00 90.82  ? 53  TYR   A O   1 
ATOM   174  C  CB  . TYR   A 1 32  ? -31.193 -10.470 -20.257 1.00 88.56  ? 53  TYR   A CB  1 
ATOM   175  C  CG  . TYR   A 1 32  ? -29.916 -9.848  -19.743 1.00 87.61  ? 53  TYR   A CG  1 
ATOM   176  C  CD1 . TYR   A 1 32  ? -28.709 -10.054 -20.397 1.00 89.71  ? 53  TYR   A CD1 1 
ATOM   177  C  CD2 . TYR   A 1 32  ? -29.917 -9.058  -18.601 1.00 87.99  ? 53  TYR   A CD2 1 
ATOM   178  C  CE1 . TYR   A 1 32  ? -27.539 -9.490  -19.928 1.00 87.15  ? 53  TYR   A CE1 1 
ATOM   179  C  CE2 . TYR   A 1 32  ? -28.752 -8.488  -18.125 1.00 88.80  ? 53  TYR   A CE2 1 
ATOM   180  C  CZ  . TYR   A 1 32  ? -27.565 -8.708  -18.793 1.00 89.12  ? 53  TYR   A CZ  1 
ATOM   181  O  OH  . TYR   A 1 32  ? -26.401 -8.144  -18.324 1.00 85.57  ? 53  TYR   A OH  1 
ATOM   182  N  N   . HIS   A 1 33  ? -33.294 -11.238 -23.022 1.00 92.82  ? 54  HIS   A N   1 
ATOM   183  C  CA  . HIS   A 1 33  ? -34.388 -12.139 -23.362 1.00 96.17  ? 54  HIS   A CA  1 
ATOM   184  C  C   . HIS   A 1 33  ? -33.932 -13.349 -24.166 1.00 97.25  ? 54  HIS   A C   1 
ATOM   185  O  O   . HIS   A 1 33  ? -34.715 -14.291 -24.330 1.00 100.74 ? 54  HIS   A O   1 
ATOM   186  C  CB  . HIS   A 1 33  ? -35.471 -11.382 -24.133 1.00 97.82  ? 54  HIS   A CB  1 
ATOM   187  C  CG  . HIS   A 1 33  ? -35.084 -11.036 -25.537 1.00 102.45 ? 54  HIS   A CG  1 
ATOM   188  N  ND1 . HIS   A 1 33  ? -35.290 -11.893 -26.597 1.00 105.56 ? 54  HIS   A ND1 1 
ATOM   189  C  CD2 . HIS   A 1 33  ? -34.500 -9.930  -26.054 1.00 99.28  ? 54  HIS   A CD2 1 
ATOM   190  C  CE1 . HIS   A 1 33  ? -34.852 -11.328 -27.708 1.00 106.43 ? 54  HIS   A CE1 1 
ATOM   191  N  NE2 . HIS   A 1 33  ? -34.367 -10.137 -27.406 1.00 102.03 ? 54  HIS   A NE2 1 
ATOM   192  N  N   . LYS   A 1 34  ? -32.699 -13.347 -24.674 1.00 94.90  ? 55  LYS   A N   1 
ATOM   193  C  CA  . LYS   A 1 34  ? -32.119 -14.505 -25.341 1.00 95.62  ? 55  LYS   A CA  1 
ATOM   194  C  C   . LYS   A 1 34  ? -31.043 -15.170 -24.491 1.00 96.65  ? 55  LYS   A C   1 
ATOM   195  O  O   . LYS   A 1 34  ? -30.238 -15.951 -25.009 1.00 100.12 ? 55  LYS   A O   1 
ATOM   196  C  CB  . LYS   A 1 34  ? -31.551 -14.105 -26.703 1.00 98.23  ? 55  LYS   A CB  1 
ATOM   197  N  N   . GLY   A 1 35  ? -31.012 -14.872 -23.197 1.00 98.40  ? 56  GLY   A N   1 
ATOM   198  C  CA  . GLY   A 1 35  ? -30.008 -15.409 -22.304 1.00 97.38  ? 56  GLY   A CA  1 
ATOM   199  C  C   . GLY   A 1 35  ? -28.740 -14.573 -22.286 1.00 93.29  ? 56  GLY   A C   1 
ATOM   200  O  O   . GLY   A 1 35  ? -28.488 -13.742 -23.158 1.00 89.20  ? 56  GLY   A O   1 
ATOM   201  N  N   . PHE   A 1 36  ? -27.929 -14.804 -21.250 1.00 91.02  ? 57  PHE   A N   1 
ATOM   202  C  CA  . PHE   A 1 36  ? -26.638 -14.131 -21.165 1.00 89.19  ? 57  PHE   A CA  1 
ATOM   203  C  C   . PHE   A 1 36  ? -25.759 -14.485 -22.355 1.00 90.50  ? 57  PHE   A C   1 
ATOM   204  O  O   . PHE   A 1 36  ? -25.011 -13.639 -22.860 1.00 88.93  ? 57  PHE   A O   1 
ATOM   205  C  CB  . PHE   A 1 36  ? -25.933 -14.500 -19.859 1.00 90.59  ? 57  PHE   A CB  1 
ATOM   206  C  CG  . PHE   A 1 36  ? -26.570 -13.911 -18.634 1.00 92.75  ? 57  PHE   A CG  1 
ATOM   207  C  CD1 . PHE   A 1 36  ? -26.601 -12.540 -18.449 1.00 94.46  ? 57  PHE   A CD1 1 
ATOM   208  C  CD2 . PHE   A 1 36  ? -27.119 -14.727 -17.660 1.00 100.37 ? 57  PHE   A CD2 1 
ATOM   209  C  CE1 . PHE   A 1 36  ? -27.181 -11.990 -17.321 1.00 97.90  ? 57  PHE   A CE1 1 
ATOM   210  C  CE2 . PHE   A 1 36  ? -27.699 -14.183 -16.528 1.00 105.78 ? 57  PHE   A CE2 1 
ATOM   211  C  CZ  . PHE   A 1 36  ? -27.730 -12.814 -16.359 1.00 104.79 ? 57  PHE   A CZ  1 
ATOM   212  N  N   . CYS   A 1 37  ? -25.842 -15.734 -22.817 1.00 92.54  ? 58  CYS   A N   1 
ATOM   213  C  CA  . CYS   A 1 37  ? -24.958 -16.209 -23.876 1.00 88.65  ? 58  CYS   A CA  1 
ATOM   214  C  C   . CYS   A 1 37  ? -25.177 -15.440 -25.174 1.00 86.21  ? 58  CYS   A C   1 
ATOM   215  O  O   . CYS   A 1 37  ? -24.227 -14.908 -25.760 1.00 81.94  ? 58  CYS   A O   1 
ATOM   216  C  CB  . CYS   A 1 37  ? -25.173 -17.708 -24.088 1.00 91.41  ? 58  CYS   A CB  1 
ATOM   217  S  SG  . CYS   A 1 37  ? -25.200 -18.685 -22.560 1.00 97.64  ? 58  CYS   A SG  1 
ATOM   218  N  N   . MET   A 1 38  ? -26.429 -15.355 -25.632 1.00 86.78  ? 59  MET   A N   1 
ATOM   219  C  CA  . MET   A 1 38  ? -26.709 -14.698 -26.907 1.00 86.19  ? 59  MET   A CA  1 
ATOM   220  C  C   . MET   A 1 38  ? -26.425 -13.202 -26.853 1.00 83.00  ? 59  MET   A C   1 
ATOM   221  O  O   . MET   A 1 38  ? -25.968 -12.624 -27.846 1.00 81.52  ? 59  MET   A O   1 
ATOM   222  C  CB  . MET   A 1 38  ? -28.157 -14.944 -27.320 1.00 88.47  ? 59  MET   A CB  1 
ATOM   223  N  N   . PHE   A 1 39  ? -26.691 -12.560 -25.713 1.00 85.42  ? 60  PHE   A N   1 
ATOM   224  C  CA  . PHE   A 1 39  ? -26.454 -11.124 -25.599 1.00 83.69  ? 60  PHE   A CA  1 
ATOM   225  C  C   . PHE   A 1 39  ? -24.974 -10.792 -25.735 1.00 82.48  ? 60  PHE   A C   1 
ATOM   226  O  O   . PHE   A 1 39  ? -24.610 -9.802  -26.381 1.00 81.56  ? 60  PHE   A O   1 
ATOM   227  C  CB  . PHE   A 1 39  ? -27.000 -10.607 -24.269 1.00 85.28  ? 60  PHE   A CB  1 
ATOM   228  C  CG  . PHE   A 1 39  ? -26.724 -9.151  -24.026 1.00 82.93  ? 60  PHE   A CG  1 
ATOM   229  C  CD1 . PHE   A 1 39  ? -27.244 -8.184  -24.869 1.00 84.58  ? 60  PHE   A CD1 1 
ATOM   230  C  CD2 . PHE   A 1 39  ? -25.949 -8.749  -22.951 1.00 82.88  ? 60  PHE   A CD2 1 
ATOM   231  C  CE1 . PHE   A 1 39  ? -26.994 -6.842  -24.647 1.00 81.56  ? 60  PHE   A CE1 1 
ATOM   232  C  CE2 . PHE   A 1 39  ? -25.697 -7.407  -22.725 1.00 81.12  ? 60  PHE   A CE2 1 
ATOM   233  C  CZ  . PHE   A 1 39  ? -26.221 -6.454  -23.575 1.00 75.04  ? 60  PHE   A CZ  1 
ATOM   234  N  N   . ASP   A 1 40  ? -24.104 -11.602 -25.126 1.00 83.34  ? 61  ASP   A N   1 
ATOM   235  C  CA  . ASP   A 1 40  ? -22.671 -11.342 -25.217 1.00 82.97  ? 61  ASP   A CA  1 
ATOM   236  C  C   . ASP   A 1 40  ? -22.142 -11.580 -26.626 1.00 82.59  ? 61  ASP   A C   1 
ATOM   237  O  O   . ASP   A 1 40  ? -21.222 -10.880 -27.066 1.00 82.73  ? 61  ASP   A O   1 
ATOM   238  C  CB  . ASP   A 1 40  ? -21.916 -12.205 -24.206 1.00 84.03  ? 61  ASP   A CB  1 
ATOM   239  C  CG  . ASP   A 1 40  ? -22.174 -11.783 -22.772 1.00 83.66  ? 61  ASP   A CG  1 
ATOM   240  O  OD1 . ASP   A 1 40  ? -22.809 -10.726 -22.565 1.00 82.46  ? 61  ASP   A OD1 1 
ATOM   241  O  OD2 . ASP   A 1 40  ? -21.742 -12.507 -21.852 1.00 81.54  ? 61  ASP   A OD2 1 
ATOM   242  N  N   . MET   A 1 41  ? -22.697 -12.562 -27.339 1.00 85.44  ? 62  MET   A N   1 
ATOM   243  C  CA  . MET   A 1 41  ? -22.257 -12.832 -28.705 1.00 82.67  ? 62  MET   A CA  1 
ATOM   244  C  C   . MET   A 1 41  ? -22.556 -11.653 -29.623 1.00 78.68  ? 62  MET   A C   1 
ATOM   245  O  O   . MET   A 1 41  ? -21.684 -11.194 -30.370 1.00 76.90  ? 62  MET   A O   1 
ATOM   246  C  CB  . MET   A 1 41  ? -22.929 -14.104 -29.225 1.00 83.05  ? 62  MET   A CB  1 
ATOM   247  C  CG  . MET   A 1 41  ? -22.590 -15.356 -28.433 1.00 81.92  ? 62  MET   A CG  1 
ATOM   248  S  SD  . MET   A 1 41  ? -21.043 -16.127 -28.946 1.00 86.23  ? 62  MET   A SD  1 
ATOM   249  C  CE  . MET   A 1 41  ? -21.629 -17.255 -30.206 1.00 89.81  ? 62  MET   A CE  1 
ATOM   250  N  N   . GLU   A 1 42  ? -23.791 -11.145 -29.577 1.00 81.89  ? 63  GLU   A N   1 
ATOM   251  C  CA  . GLU   A 1 42  ? -24.190 -10.070 -30.481 1.00 81.00  ? 63  GLU   A CA  1 
ATOM   252  C  C   . GLU   A 1 42  ? -23.411 -8.788  -30.208 1.00 78.95  ? 63  GLU   A C   1 
ATOM   253  O  O   . GLU   A 1 42  ? -22.979 -8.105  -31.144 1.00 77.51  ? 63  GLU   A O   1 
ATOM   254  C  CB  . GLU   A 1 42  ? -25.693 -9.820  -30.365 1.00 80.67  ? 63  GLU   A CB  1 
ATOM   255  C  CG  . GLU   A 1 42  ? -26.553 -10.998 -30.792 1.00 85.10  ? 63  GLU   A CG  1 
ATOM   256  C  CD  . GLU   A 1 42  ? -28.026 -10.647 -30.847 1.00 100.08 ? 63  GLU   A CD  1 
ATOM   257  O  OE1 . GLU   A 1 42  ? -28.383 -9.529  -30.420 1.00 100.78 ? 63  GLU   A OE1 1 
ATOM   258  O  OE2 . GLU   A 1 42  ? -28.825 -11.483 -31.321 1.00 104.94 ? 63  GLU   A OE2 1 
ATOM   259  N  N   . CYS   A 1 43  ? -23.227 -8.442  -28.931 1.00 80.28  ? 64  CYS   A N   1 
ATOM   260  C  CA  . CYS   A 1 43  ? -22.484 -7.232  -28.592 1.00 80.57  ? 64  CYS   A CA  1 
ATOM   261  C  C   . CYS   A 1 43  ? -21.040 -7.321  -29.064 1.00 77.98  ? 64  CYS   A C   1 
ATOM   262  O  O   . CYS   A 1 43  ? -20.472 -6.334  -29.546 1.00 77.87  ? 64  CYS   A O   1 
ATOM   263  C  CB  . CYS   A 1 43  ? -22.541 -6.987  -27.085 1.00 82.70  ? 64  CYS   A CB  1 
ATOM   264  S  SG  . CYS   A 1 43  ? -24.144 -6.417  -26.489 1.00 80.72  ? 64  CYS   A SG  1 
ATOM   265  N  N   . HIS   A 1 44  ? -20.430 -8.499  -28.927 1.00 76.95  ? 65  HIS   A N   1 
ATOM   266  C  CA  . HIS   A 1 44  ? -19.059 -8.686  -29.386 1.00 80.17  ? 65  HIS   A CA  1 
ATOM   267  C  C   . HIS   A 1 44  ? -18.952 -8.484  -30.893 1.00 80.06  ? 65  HIS   A C   1 
ATOM   268  O  O   . HIS   A 1 44  ? -18.009 -7.848  -31.377 1.00 80.79  ? 65  HIS   A O   1 
ATOM   269  C  CB  . HIS   A 1 44  ? -18.571 -10.079 -28.984 1.00 79.76  ? 65  HIS   A CB  1 
ATOM   270  C  CG  . HIS   A 1 44  ? -17.144 -10.348 -29.341 1.00 79.47  ? 65  HIS   A CG  1 
ATOM   271  N  ND1 . HIS   A 1 44  ? -16.161 -9.386  -29.256 1.00 81.36  ? 65  HIS   A ND1 1 
ATOM   272  C  CD2 . HIS   A 1 44  ? -16.532 -11.475 -29.775 1.00 83.29  ? 65  HIS   A CD2 1 
ATOM   273  C  CE1 . HIS   A 1 44  ? -15.006 -9.907  -29.629 1.00 81.61  ? 65  HIS   A CE1 1 
ATOM   274  N  NE2 . HIS   A 1 44  ? -15.203 -11.174 -29.949 1.00 81.48  ? 65  HIS   A NE2 1 
ATOM   275  N  N   . LYS   A 1 45  ? -19.921 -9.006  -31.650 1.00 77.72  ? 66  LYS   A N   1 
ATOM   276  C  CA  . LYS   A 1 45  ? -19.878 -8.874  -33.102 1.00 79.35  ? 66  LYS   A CA  1 
ATOM   277  C  C   . LYS   A 1 45  ? -20.145 -7.443  -33.553 1.00 79.41  ? 66  LYS   A C   1 
ATOM   278  O  O   . LYS   A 1 45  ? -19.591 -7.002  -34.566 1.00 78.10  ? 66  LYS   A O   1 
ATOM   279  C  CB  . LYS   A 1 45  ? -20.886 -9.826  -33.748 1.00 75.90  ? 66  LYS   A CB  1 
ATOM   280  N  N   . LYS   A 1 46  ? -20.981 -6.705  -32.824 1.00 81.13  ? 67  LYS   A N   1 
ATOM   281  C  CA  . LYS   A 1 46  ? -21.385 -5.372  -33.257 1.00 80.01  ? 67  LYS   A CA  1 
ATOM   282  C  C   . LYS   A 1 46  ? -20.411 -4.283  -32.822 1.00 84.22  ? 67  LYS   A C   1 
ATOM   283  O  O   . LYS   A 1 46  ? -20.084 -3.397  -33.619 1.00 88.39  ? 67  LYS   A O   1 
ATOM   284  C  CB  . LYS   A 1 46  ? -22.786 -5.050  -32.728 1.00 73.99  ? 67  LYS   A CB  1 
ATOM   285  N  N   . TYR   A 1 47  ? -19.936 -4.326  -31.577 1.00 83.40  ? 68  TYR   A N   1 
ATOM   286  C  CA  . TYR   A 1 47  ? -19.152 -3.232  -31.020 1.00 81.33  ? 68  TYR   A CA  1 
ATOM   287  C  C   . TYR   A 1 47  ? -17.656 -3.513  -30.968 1.00 84.06  ? 68  TYR   A C   1 
ATOM   288  O  O   . TYR   A 1 47  ? -16.879 -2.585  -30.717 1.00 84.94  ? 68  TYR   A O   1 
ATOM   289  C  CB  . TYR   A 1 47  ? -19.662 -2.889  -29.617 1.00 81.33  ? 68  TYR   A CB  1 
ATOM   290  C  CG  . TYR   A 1 47  ? -21.151 -2.643  -29.582 1.00 82.68  ? 68  TYR   A CG  1 
ATOM   291  C  CD1 . TYR   A 1 47  ? -21.695 -1.497  -30.146 1.00 81.73  ? 68  TYR   A CD1 1 
ATOM   292  C  CD2 . TYR   A 1 47  ? -22.014 -3.562  -29.000 1.00 81.63  ? 68  TYR   A CD2 1 
ATOM   293  C  CE1 . TYR   A 1 47  ? -23.057 -1.269  -30.126 1.00 81.73  ? 68  TYR   A CE1 1 
ATOM   294  C  CE2 . TYR   A 1 47  ? -23.377 -3.342  -28.975 1.00 81.93  ? 68  TYR   A CE2 1 
ATOM   295  C  CZ  . TYR   A 1 47  ? -23.893 -2.194  -29.539 1.00 83.49  ? 68  TYR   A CZ  1 
ATOM   296  O  OH  . TYR   A 1 47  ? -25.249 -1.970  -29.518 1.00 89.29  ? 68  TYR   A OH  1 
ATOM   297  N  N   . GLY   A 1 48  ? -17.231 -4.753  -31.194 1.00 81.89  ? 69  GLY   A N   1 
ATOM   298  C  CA  . GLY   A 1 48  ? -15.814 -5.043  -31.288 1.00 81.42  ? 69  GLY   A CA  1 
ATOM   299  C  C   . GLY   A 1 48  ? -15.160 -5.507  -30.003 1.00 80.62  ? 69  GLY   A C   1 
ATOM   300  O  O   . GLY   A 1 48  ? -15.724 -6.318  -29.262 1.00 81.65  ? 69  GLY   A O   1 
ATOM   301  N  N   . LYS   A 1 49  ? -13.960 -4.988  -29.732 1.00 78.56  ? 70  LYS   A N   1 
ATOM   302  C  CA  . LYS   A 1 49  ? -13.144 -5.495  -28.632 1.00 78.33  ? 70  LYS   A CA  1 
ATOM   303  C  C   . LYS   A 1 49  ? -13.665 -5.052  -27.269 1.00 80.05  ? 70  LYS   A C   1 
ATOM   304  O  O   . LYS   A 1 49  ? -13.618 -5.826  -26.306 1.00 80.63  ? 70  LYS   A O   1 
ATOM   305  C  CB  . LYS   A 1 49  ? -11.692 -5.050  -28.813 1.00 79.00  ? 70  LYS   A CB  1 
ATOM   306  N  N   . VAL   A 1 50  ? -14.154 -3.818  -27.160 1.00 79.06  ? 71  VAL   A N   1 
ATOM   307  C  CA  . VAL   A 1 50  ? -14.582 -3.249  -25.886 1.00 77.92  ? 71  VAL   A CA  1 
ATOM   308  C  C   . VAL   A 1 50  ? -15.944 -2.595  -26.069 1.00 81.31  ? 71  VAL   A C   1 
ATOM   309  O  O   . VAL   A 1 50  ? -16.150 -1.837  -27.023 1.00 82.94  ? 71  VAL   A O   1 
ATOM   310  C  CB  . VAL   A 1 50  ? -13.559 -2.229  -25.348 1.00 78.59  ? 71  VAL   A CB  1 
ATOM   311  C  CG1 . VAL   A 1 50  ? -14.163 -1.399  -24.227 1.00 81.10  ? 71  VAL   A CG1 1 
ATOM   312  C  CG2 . VAL   A 1 50  ? -12.314 -2.945  -24.859 1.00 85.64  ? 71  VAL   A CG2 1 
ATOM   313  N  N   . TRP   A 1 51  ? -16.867 -2.887  -25.154 1.00 79.84  ? 72  TRP   A N   1 
ATOM   314  C  CA  . TRP   A 1 51  ? -18.181 -2.262  -25.153 1.00 79.55  ? 72  TRP   A CA  1 
ATOM   315  C  C   . TRP   A 1 51  ? -18.712 -2.239  -23.728 1.00 78.87  ? 72  TRP   A C   1 
ATOM   316  O  O   . TRP   A 1 51  ? -18.213 -2.943  -22.846 1.00 77.83  ? 72  TRP   A O   1 
ATOM   317  C  CB  . TRP   A 1 51  ? -19.164 -2.990  -26.078 1.00 78.43  ? 72  TRP   A CB  1 
ATOM   318  C  CG  . TRP   A 1 51  ? -19.648 -4.301  -25.538 1.00 79.12  ? 72  TRP   A CG  1 
ATOM   319  C  CD1 . TRP   A 1 51  ? -20.761 -4.512  -24.775 1.00 78.27  ? 72  TRP   A CD1 1 
ATOM   320  C  CD2 . TRP   A 1 51  ? -19.039 -5.585  -25.722 1.00 78.19  ? 72  TRP   A CD2 1 
ATOM   321  N  NE1 . TRP   A 1 51  ? -20.880 -5.846  -24.471 1.00 76.31  ? 72  TRP   A NE1 1 
ATOM   322  C  CE2 . TRP   A 1 51  ? -19.836 -6.527  -25.041 1.00 73.76  ? 72  TRP   A CE2 1 
ATOM   323  C  CE3 . TRP   A 1 51  ? -17.897 -6.029  -26.396 1.00 78.87  ? 72  TRP   A CE3 1 
ATOM   324  C  CZ2 . TRP   A 1 51  ? -19.529 -7.886  -25.016 1.00 74.89  ? 72  TRP   A CZ2 1 
ATOM   325  C  CZ3 . TRP   A 1 51  ? -17.593 -7.379  -26.368 1.00 78.84  ? 72  TRP   A CZ3 1 
ATOM   326  C  CH2 . TRP   A 1 51  ? -18.406 -8.291  -25.683 1.00 78.32  ? 72  TRP   A CH2 1 
ATOM   327  N  N   . GLY   A 1 52  ? -19.734 -1.421  -23.515 1.00 79.72  ? 73  GLY   A N   1 
ATOM   328  C  CA  . GLY   A 1 52  ? -20.335 -1.288  -22.201 1.00 77.69  ? 73  GLY   A CA  1 
ATOM   329  C  C   . GLY   A 1 52  ? -21.844 -1.252  -22.290 1.00 76.35  ? 73  GLY   A C   1 
ATOM   330  O  O   . GLY   A 1 52  ? -22.422 -0.761  -23.262 1.00 77.57  ? 73  GLY   A O   1 
ATOM   331  N  N   . PHE   A 1 53  ? -22.482 -1.785  -21.250 1.00 75.65  ? 74  PHE   A N   1 
ATOM   332  C  CA  . PHE   A 1 53  ? -23.932 -1.801  -21.131 1.00 76.95  ? 74  PHE   A CA  1 
ATOM   333  C  C   . PHE   A 1 53  ? -24.290 -1.554  -19.672 1.00 74.53  ? 74  PHE   A C   1 
ATOM   334  O  O   . PHE   A 1 53  ? -23.417 -1.320  -18.830 1.00 75.36  ? 74  PHE   A O   1 
ATOM   335  C  CB  . PHE   A 1 53  ? -24.521 -3.120  -21.650 1.00 75.13  ? 74  PHE   A CB  1 
ATOM   336  C  CG  . PHE   A 1 53  ? -23.981 -4.342  -20.961 1.00 75.61  ? 74  PHE   A CG  1 
ATOM   337  C  CD1 . PHE   A 1 53  ? -22.782 -4.908  -21.362 1.00 73.18  ? 74  PHE   A CD1 1 
ATOM   338  C  CD2 . PHE   A 1 53  ? -24.679 -4.931  -19.921 1.00 76.23  ? 74  PHE   A CD2 1 
ATOM   339  C  CE1 . PHE   A 1 53  ? -22.285 -6.033  -20.732 1.00 70.60  ? 74  PHE   A CE1 1 
ATOM   340  C  CE2 . PHE   A 1 53  ? -24.187 -6.057  -19.288 1.00 74.74  ? 74  PHE   A CE2 1 
ATOM   341  C  CZ  . PHE   A 1 53  ? -22.990 -6.608  -19.694 1.00 72.91  ? 74  PHE   A CZ  1 
ATOM   342  N  N   . TYR   A 1 54  ? -25.584 -1.603  -19.367 1.00 75.43  ? 75  TYR   A N   1 
ATOM   343  C  CA  . TYR   A 1 54  ? -26.076 -1.275  -18.036 1.00 77.83  ? 75  TYR   A CA  1 
ATOM   344  C  C   . TYR   A 1 54  ? -27.020 -2.360  -17.542 1.00 79.97  ? 75  TYR   A C   1 
ATOM   345  O  O   . TYR   A 1 54  ? -27.951 -2.753  -18.253 1.00 81.50  ? 75  TYR   A O   1 
ATOM   346  C  CB  . TYR   A 1 54  ? -26.786 0.082   -18.033 1.00 79.19  ? 75  TYR   A CB  1 
ATOM   347  C  CG  . TYR   A 1 54  ? -25.898 1.238   -18.431 1.00 78.62  ? 75  TYR   A CG  1 
ATOM   348  C  CD1 . TYR   A 1 54  ? -25.676 1.540   -19.768 1.00 80.65  ? 75  TYR   A CD1 1 
ATOM   349  C  CD2 . TYR   A 1 54  ? -25.285 2.029   -17.471 1.00 77.24  ? 75  TYR   A CD2 1 
ATOM   350  C  CE1 . TYR   A 1 54  ? -24.864 2.595   -20.136 1.00 79.93  ? 75  TYR   A CE1 1 
ATOM   351  C  CE2 . TYR   A 1 54  ? -24.473 3.085   -17.829 1.00 79.44  ? 75  TYR   A CE2 1 
ATOM   352  C  CZ  . TYR   A 1 54  ? -24.266 3.365   -19.162 1.00 79.91  ? 75  TYR   A CZ  1 
ATOM   353  O  OH  . TYR   A 1 54  ? -23.457 4.418   -19.520 1.00 83.95  ? 75  TYR   A OH  1 
ATOM   354  N  N   . ASP   A 1 55  ? -26.774 -2.838  -16.323 1.00 82.08  ? 76  ASP   A N   1 
ATOM   355  C  CA  . ASP   A 1 55  ? -27.690 -3.727  -15.612 1.00 80.14  ? 76  ASP   A CA  1 
ATOM   356  C  C   . ASP   A 1 55  ? -28.460 -2.854  -14.627 1.00 83.26  ? 76  ASP   A C   1 
ATOM   357  O  O   . ASP   A 1 55  ? -28.057 -2.673  -13.478 1.00 85.19  ? 76  ASP   A O   1 
ATOM   358  C  CB  . ASP   A 1 55  ? -26.934 -4.853  -14.914 1.00 79.70  ? 76  ASP   A CB  1 
ATOM   359  C  CG  . ASP   A 1 55  ? -26.436 -5.908  -15.881 1.00 78.99  ? 76  ASP   A CG  1 
ATOM   360  O  OD1 . ASP   A 1 55  ? -26.993 -6.003  -16.994 1.00 83.87  ? 76  ASP   A OD1 1 
ATOM   361  O  OD2 . ASP   A 1 55  ? -25.496 -6.649  -15.525 1.00 76.99  ? 76  ASP   A OD2 1 
ATOM   362  N  N   . GLY   A 1 56  ? -29.582 -2.307  -15.088 1.00 83.50  ? 77  GLY   A N   1 
ATOM   363  C  CA  . GLY   A 1 56  ? -30.284 -1.291  -14.330 1.00 85.92  ? 77  GLY   A CA  1 
ATOM   364  C  C   . GLY   A 1 56  ? -29.538 0.024   -14.396 1.00 83.40  ? 77  GLY   A C   1 
ATOM   365  O  O   . GLY   A 1 56  ? -29.398 0.610   -15.474 1.00 86.31  ? 77  GLY   A O   1 
ATOM   366  N  N   . GLN   A 1 57  ? -29.049 0.499   -13.252 1.00 84.17  ? 78  GLN   A N   1 
ATOM   367  C  CA  . GLN   A 1 57  ? -28.161 1.652   -13.208 1.00 82.39  ? 78  GLN   A CA  1 
ATOM   368  C  C   . GLN   A 1 57  ? -26.687 1.265   -13.199 1.00 78.31  ? 78  GLN   A C   1 
ATOM   369  O  O   . GLN   A 1 57  ? -25.833 2.147   -13.341 1.00 78.78  ? 78  GLN   A O   1 
ATOM   370  C  CB  . GLN   A 1 57  ? -28.464 2.510   -11.972 1.00 87.89  ? 78  GLN   A CB  1 
ATOM   371  C  CG  . GLN   A 1 57  ? -29.872 3.084   -11.929 1.00 92.29  ? 78  GLN   A CG  1 
ATOM   372  C  CD  . GLN   A 1 57  ? -30.008 4.359   -12.736 1.00 93.52  ? 78  GLN   A CD  1 
ATOM   373  O  OE1 . GLN   A 1 57  ? -30.448 4.337   -13.886 1.00 94.93  ? 78  GLN   A OE1 1 
ATOM   374  N  NE2 . GLN   A 1 57  ? -29.630 5.482   -12.135 1.00 94.31  ? 78  GLN   A NE2 1 
ATOM   375  N  N   . GLN   A 1 58  ? -26.372 -0.019  -13.053 1.00 76.77  ? 79  GLN   A N   1 
ATOM   376  C  CA  . GLN   A 1 58  ? -24.987 -0.451  -12.895 1.00 76.17  ? 79  GLN   A CA  1 
ATOM   377  C  C   . GLN   A 1 58  ? -24.293 -0.531  -14.250 1.00 75.96  ? 79  GLN   A C   1 
ATOM   378  O  O   . GLN   A 1 58  ? -24.703 -1.332  -15.097 1.00 73.76  ? 79  GLN   A O   1 
ATOM   379  C  CB  . GLN   A 1 58  ? -24.930 -1.809  -12.207 1.00 75.91  ? 79  GLN   A CB  1 
ATOM   380  C  CG  . GLN   A 1 58  ? -23.537 -2.417  -12.142 1.00 72.49  ? 79  GLN   A CG  1 
ATOM   381  C  CD  . GLN   A 1 58  ? -22.577 -1.582  -11.319 1.00 70.67  ? 79  GLN   A CD  1 
ATOM   382  O  OE1 . GLN   A 1 58  ? -22.846 -1.270  -10.159 1.00 74.36  ? 79  GLN   A OE1 1 
ATOM   383  N  NE2 . GLN   A 1 58  ? -21.453 -1.210  -11.919 1.00 70.40  ? 79  GLN   A NE2 1 
ATOM   384  N  N   . PRO   A 1 59  ? -23.246 0.256   -14.491 1.00 76.19  ? 80  PRO   A N   1 
ATOM   385  C  CA  . PRO   A 1 59  ? -22.498 0.123   -15.745 1.00 72.39  ? 80  PRO   A CA  1 
ATOM   386  C  C   . PRO   A 1 59  ? -21.567 -1.079  -15.708 1.00 70.26  ? 80  PRO   A C   1 
ATOM   387  O  O   . PRO   A 1 59  ? -20.884 -1.335  -14.713 1.00 69.83  ? 80  PRO   A O   1 
ATOM   388  C  CB  . PRO   A 1 59  ? -21.711 1.437   -15.824 1.00 73.65  ? 80  PRO   A CB  1 
ATOM   389  C  CG  . PRO   A 1 59  ? -21.511 1.825   -14.400 1.00 73.39  ? 80  PRO   A CG  1 
ATOM   390  C  CD  . PRO   A 1 59  ? -22.738 1.359   -13.655 1.00 73.13  ? 80  PRO   A CD  1 
ATOM   391  N  N   . VAL   A 1 60  ? -21.549 -1.828  -16.808 1.00 73.19  ? 81  VAL   A N   1 
ATOM   392  C  CA  . VAL   A 1 60  ? -20.707 -3.012  -16.940 1.00 72.92  ? 81  VAL   A CA  1 
ATOM   393  C  C   . VAL   A 1 60  ? -19.858 -2.849  -18.191 1.00 74.48  ? 81  VAL   A C   1 
ATOM   394  O  O   . VAL   A 1 60  ? -20.393 -2.632  -19.285 1.00 77.19  ? 81  VAL   A O   1 
ATOM   395  C  CB  . VAL   A 1 60  ? -21.535 -4.306  -17.015 1.00 68.88  ? 81  VAL   A CB  1 
ATOM   396  C  CG1 . VAL   A 1 60  ? -20.619 -5.511  -17.142 1.00 69.14  ? 81  VAL   A CG1 1 
ATOM   397  C  CG2 . VAL   A 1 60  ? -22.430 -4.438  -15.791 1.00 70.71  ? 81  VAL   A CG2 1 
ATOM   398  N  N   . LEU   A 1 61  ? -18.542 -2.960  -18.035 1.00 73.93  ? 82  LEU   A N   1 
ATOM   399  C  CA  . LEU   A 1 61  ? -17.608 -2.827  -19.145 1.00 72.24  ? 82  LEU   A CA  1 
ATOM   400  C  C   . LEU   A 1 61  ? -17.084 -4.206  -19.521 1.00 71.00  ? 82  LEU   A C   1 
ATOM   401  O  O   . LEU   A 1 61  ? -16.457 -4.882  -18.698 1.00 69.26  ? 82  LEU   A O   1 
ATOM   402  C  CB  . LEU   A 1 61  ? -16.454 -1.896  -18.778 1.00 73.22  ? 82  LEU   A CB  1 
ATOM   403  C  CG  . LEU   A 1 61  ? -15.352 -1.791  -19.833 1.00 71.36  ? 82  LEU   A CG  1 
ATOM   404  C  CD1 . LEU   A 1 61  ? -15.863 -1.064  -21.065 1.00 74.78  ? 82  LEU   A CD1 1 
ATOM   405  C  CD2 . LEU   A 1 61  ? -14.118 -1.107  -19.269 1.00 72.39  ? 82  LEU   A CD2 1 
ATOM   406  N  N   . ALA   A 1 62  ? -17.336 -4.617  -20.760 1.00 70.50  ? 83  ALA   A N   1 
ATOM   407  C  CA  . ALA   A 1 62  ? -16.870 -5.904  -21.253 1.00 70.02  ? 83  ALA   A CA  1 
ATOM   408  C  C   . ALA   A 1 62  ? -15.543 -5.724  -21.976 1.00 74.85  ? 83  ALA   A C   1 
ATOM   409  O  O   . ALA   A 1 62  ? -15.429 -4.892  -22.882 1.00 79.33  ? 83  ALA   A O   1 
ATOM   410  C  CB  . ALA   A 1 62  ? -17.902 -6.535  -22.187 1.00 70.57  ? 83  ALA   A CB  1 
ATOM   411  N  N   . ILE   A 1 63  ? -14.544 -6.501  -21.570 1.00 70.42  ? 84  ILE   A N   1 
ATOM   412  C  CA  . ILE   A 1 63  ? -13.218 -6.454  -22.170 1.00 70.94  ? 84  ILE   A CA  1 
ATOM   413  C  C   . ILE   A 1 63  ? -12.918 -7.811  -22.788 1.00 74.59  ? 84  ILE   A C   1 
ATOM   414  O  O   . ILE   A 1 63  ? -13.361 -8.853  -22.295 1.00 75.48  ? 84  ILE   A O   1 
ATOM   415  C  CB  . ILE   A 1 63  ? -12.130 -6.061  -21.146 1.00 74.19  ? 84  ILE   A CB  1 
ATOM   416  C  CG1 . ILE   A 1 63  ? -12.004 -7.125  -20.053 1.00 74.40  ? 84  ILE   A CG1 1 
ATOM   417  C  CG2 . ILE   A 1 63  ? -12.443 -4.704  -20.536 1.00 73.44  ? 84  ILE   A CG2 1 
ATOM   418  C  CD1 . ILE   A 1 63  ? -10.869 -6.878  -19.085 1.00 72.57  ? 84  ILE   A CD1 1 
ATOM   419  N  N   . THR   A 1 64  ? -12.169 -7.791  -23.892 1.00 79.21  ? 85  THR   A N   1 
ATOM   420  C  CA  . THR   A 1 64  ? -11.816 -9.012  -24.604 1.00 77.63  ? 85  THR   A CA  1 
ATOM   421  C  C   . THR   A 1 64  ? -10.342 -9.114  -24.970 1.00 82.61  ? 85  THR   A C   1 
ATOM   422  O  O   . THR   A 1 64  ? -9.923  -10.174 -25.449 1.00 85.90  ? 85  THR   A O   1 
ATOM   423  C  CB  . THR   A 1 64  ? -12.646 -9.150  -25.890 1.00 78.15  ? 85  THR   A CB  1 
ATOM   424  O  OG1 . THR   A 1 64  ? -12.480 -7.977  -26.695 1.00 77.69  ? 85  THR   A OG1 1 
ATOM   425  C  CG2 . THR   A 1 64  ? -14.125 -9.334  -25.563 1.00 77.28  ? 85  THR   A CG2 1 
ATOM   426  N  N   . ASP   A 1 65  ? -9.553  -8.068  -24.771 1.00 83.92  ? 86  ASP   A N   1 
ATOM   427  C  CA  . ASP   A 1 65  ? -8.128  -8.124  -25.084 1.00 83.23  ? 86  ASP   A CA  1 
ATOM   428  C  C   . ASP   A 1 65  ? -7.412  -9.017  -24.079 1.00 84.28  ? 86  ASP   A C   1 
ATOM   429  O  O   . ASP   A 1 65  ? -7.520  -8.778  -22.869 1.00 83.72  ? 86  ASP   A O   1 
ATOM   430  C  CB  . ASP   A 1 65  ? -7.534  -6.721  -25.075 1.00 82.94  ? 86  ASP   A CB  1 
ATOM   431  C  CG  . ASP   A 1 65  ? -6.037  -6.720  -25.303 1.00 83.74  ? 86  ASP   A CG  1 
ATOM   432  O  OD1 . ASP   A 1 65  ? -5.611  -6.948  -26.455 1.00 83.65  ? 86  ASP   A OD1 1 
ATOM   433  O  OD2 . ASP   A 1 65  ? -5.288  -6.490  -24.331 1.00 87.64  ? 86  ASP   A OD2 1 
ATOM   434  N  N   . PRO   A 1 66  ? -6.682  -10.047 -24.522 1.00 81.90  ? 87  PRO   A N   1 
ATOM   435  C  CA  . PRO   A 1 66  ? -6.036  -10.952 -23.554 1.00 82.20  ? 87  PRO   A CA  1 
ATOM   436  C  C   . PRO   A 1 66  ? -5.059  -10.257 -22.619 1.00 83.24  ? 87  PRO   A C   1 
ATOM   437  O  O   . PRO   A 1 66  ? -4.960  -10.639 -21.446 1.00 83.37  ? 87  PRO   A O   1 
ATOM   438  C  CB  . PRO   A 1 66  ? -5.336  -11.982 -24.453 1.00 82.13  ? 87  PRO   A CB  1 
ATOM   439  C  CG  . PRO   A 1 66  ? -5.212  -11.318 -25.786 1.00 84.46  ? 87  PRO   A CG  1 
ATOM   440  C  CD  . PRO   A 1 66  ? -6.419  -10.444 -25.914 1.00 81.05  ? 87  PRO   A CD  1 
ATOM   441  N  N   . ASP   A 1 67  ? -4.323  -9.253  -23.104 1.00 83.27  ? 88  ASP   A N   1 
ATOM   442  C  CA  . ASP   A 1 67  ? -3.456  -8.485  -22.215 1.00 85.22  ? 88  ASP   A CA  1 
ATOM   443  C  C   . ASP   A 1 67  ? -4.275  -7.713  -21.189 1.00 84.56  ? 88  ASP   A C   1 
ATOM   444  O  O   . ASP   A 1 67  ? -3.901  -7.638  -20.012 1.00 84.66  ? 88  ASP   A O   1 
ATOM   445  C  CB  . ASP   A 1 67  ? -2.576  -7.532  -23.023 1.00 88.38  ? 88  ASP   A CB  1 
ATOM   446  C  CG  . ASP   A 1 67  ? -1.876  -8.221  -24.175 1.00 92.40  ? 88  ASP   A CG  1 
ATOM   447  O  OD1 . ASP   A 1 67  ? -2.536  -8.475  -25.206 1.00 94.04  ? 88  ASP   A OD1 1 
ATOM   448  O  OD2 . ASP   A 1 67  ? -0.667  -8.509  -24.051 1.00 90.98  ? 88  ASP   A OD2 1 
ATOM   449  N  N   . MET   A 1 68  ? -5.395  -7.131  -21.622 1.00 84.28  ? 89  MET   A N   1 
ATOM   450  C  CA  . MET   A 1 68  ? -6.268  -6.406  -20.706 1.00 84.63  ? 89  MET   A CA  1 
ATOM   451  C  C   . MET   A 1 68  ? -6.958  -7.347  -19.726 1.00 80.87  ? 89  MET   A C   1 
ATOM   452  O  O   . MET   A 1 68  ? -7.185  -6.978  -18.568 1.00 81.59  ? 89  MET   A O   1 
ATOM   453  C  CB  . MET   A 1 68  ? -7.291  -5.603  -21.503 1.00 84.52  ? 89  MET   A CB  1 
ATOM   454  C  CG  . MET   A 1 68  ? -8.288  -4.839  -20.664 1.00 83.63  ? 89  MET   A CG  1 
ATOM   455  S  SD  . MET   A 1 68  ? -8.991  -3.461  -21.582 1.00 87.48  ? 89  MET   A SD  1 
ATOM   456  C  CE  . MET   A 1 68  ? -9.424  -4.269  -23.118 1.00 83.36  ? 89  MET   A CE  1 
ATOM   457  N  N   . ILE   A 1 69  ? -7.297  -8.561  -20.167 1.00 77.47  ? 90  ILE   A N   1 
ATOM   458  C  CA  . ILE   A 1 69  ? -7.865  -9.551  -19.258 1.00 77.94  ? 90  ILE   A CA  1 
ATOM   459  C  C   . ILE   A 1 69  ? -6.849  -9.943  -18.194 1.00 78.94  ? 90  ILE   A C   1 
ATOM   460  O  O   . ILE   A 1 69  ? -7.189  -10.088 -17.013 1.00 78.85  ? 90  ILE   A O   1 
ATOM   461  C  CB  . ILE   A 1 69  ? -8.365  -10.774 -20.049 1.00 77.04  ? 90  ILE   A CB  1 
ATOM   462  C  CG1 . ILE   A 1 69  ? -9.533  -10.380 -20.957 1.00 77.31  ? 90  ILE   A CG1 1 
ATOM   463  C  CG2 . ILE   A 1 69  ? -8.774  -11.894 -19.106 1.00 74.22  ? 90  ILE   A CG2 1 
ATOM   464  C  CD1 . ILE   A 1 69  ? -10.053 -11.514 -21.810 1.00 76.06  ? 90  ILE   A CD1 1 
ATOM   465  N  N   . LYS   A 1 70  ? -5.586  -10.120 -18.593 1.00 80.77  ? 91  LYS   A N   1 
ATOM   466  C  CA  . LYS   A 1 70  ? -4.549  -10.498 -17.636 1.00 80.23  ? 91  LYS   A CA  1 
ATOM   467  C  C   . LYS   A 1 70  ? -4.323  -9.404  -16.599 1.00 79.50  ? 91  LYS   A C   1 
ATOM   468  O  O   . LYS   A 1 70  ? -4.105  -9.693  -15.417 1.00 76.61  ? 91  LYS   A O   1 
ATOM   469  C  CB  . LYS   A 1 70  ? -3.247  -10.816 -18.371 1.00 82.33  ? 91  LYS   A CB  1 
ATOM   470  C  CG  . LYS   A 1 70  ? -2.083  -11.162 -17.453 1.00 84.59  ? 91  LYS   A CG  1 
ATOM   471  C  CD  . LYS   A 1 70  ? -0.858  -11.598 -18.243 1.00 82.21  ? 91  LYS   A CD  1 
ATOM   472  C  CE  . LYS   A 1 70  ? 0.254   -12.065 -17.317 1.00 80.82  ? 91  LYS   A CE  1 
ATOM   473  N  NZ  . LYS   A 1 70  ? 1.391   -12.668 -18.065 1.00 80.93  ? 91  LYS   A NZ  1 
ATOM   474  N  N   . THR   A 1 71  ? -4.361  -8.139  -17.026 1.00 78.87  ? 92  THR   A N   1 
ATOM   475  C  CA  . THR   A 1 71  ? -4.166  -7.039  -16.087 1.00 78.64  ? 92  THR   A CA  1 
ATOM   476  C  C   . THR   A 1 71  ? -5.271  -7.005  -15.038 1.00 80.79  ? 92  THR   A C   1 
ATOM   477  O  O   . THR   A 1 71  ? -5.006  -6.775  -13.852 1.00 81.70  ? 92  THR   A O   1 
ATOM   478  C  CB  . THR   A 1 71  ? -4.107  -5.710  -16.840 1.00 80.09  ? 92  THR   A CB  1 
ATOM   479  O  OG1 . THR   A 1 71  ? -3.110  -5.787  -17.866 1.00 89.17  ? 92  THR   A OG1 1 
ATOM   480  C  CG2 . THR   A 1 71  ? -3.755  -4.580  -15.889 1.00 79.88  ? 92  THR   A CG2 1 
ATOM   481  N  N   . VAL   A 1 72  ? -6.517  -7.229  -15.458 1.00 81.83  ? 93  VAL   A N   1 
ATOM   482  C  CA  . VAL   A 1 72  ? -7.638  -7.182  -14.524 1.00 79.38  ? 93  VAL   A CA  1 
ATOM   483  C  C   . VAL   A 1 72  ? -7.610  -8.378  -13.579 1.00 79.29  ? 93  VAL   A C   1 
ATOM   484  O  O   . VAL   A 1 72  ? -7.799  -8.231  -12.365 1.00 73.69  ? 93  VAL   A O   1 
ATOM   485  C  CB  . VAL   A 1 72  ? -8.964  -7.099  -15.301 1.00 73.29  ? 93  VAL   A CB  1 
ATOM   486  C  CG1 . VAL   A 1 72  ? -10.146 -7.256  -14.358 1.00 70.38  ? 93  VAL   A CG1 1 
ATOM   487  C  CG2 . VAL   A 1 72  ? -9.047  -5.780  -16.051 1.00 72.87  ? 93  VAL   A CG2 1 
ATOM   488  N  N   . LEU   A 1 73  ? -7.366  -9.574  -14.112 1.00 77.81  ? 94  LEU   A N   1 
ATOM   489  C  CA  . LEU   A 1 73  ? -7.494  -10.791 -13.323 1.00 74.52  ? 94  LEU   A CA  1 
ATOM   490  C  C   . LEU   A 1 73  ? -6.231  -11.157 -12.556 1.00 78.54  ? 94  LEU   A C   1 
ATOM   491  O  O   . LEU   A 1 73  ? -6.327  -11.846 -11.534 1.00 77.42  ? 94  LEU   A O   1 
ATOM   492  C  CB  . LEU   A 1 73  ? -7.897  -11.962 -14.226 1.00 73.55  ? 94  LEU   A CB  1 
ATOM   493  C  CG  . LEU   A 1 73  ? -9.250  -11.821 -14.932 1.00 75.46  ? 94  LEU   A CG  1 
ATOM   494  C  CD1 . LEU   A 1 73  ? -9.599  -13.077 -15.720 1.00 70.18  ? 94  LEU   A CD1 1 
ATOM   495  C  CD2 . LEU   A 1 73  ? -10.350 -11.488 -13.932 1.00 77.12  ? 94  LEU   A CD2 1 
ATOM   496  N  N   . VAL   A 1 74  ? -5.055  -10.725 -13.011 1.00 81.36  ? 95  VAL   A N   1 
ATOM   497  C  CA  . VAL   A 1 74  ? -3.811  -11.160 -12.384 1.00 79.70  ? 95  VAL   A CA  1 
ATOM   498  C  C   . VAL   A 1 74  ? -2.995  -9.967  -11.899 1.00 78.99  ? 95  VAL   A C   1 
ATOM   499  O  O   . VAL   A 1 74  ? -2.714  -9.844  -10.701 1.00 80.68  ? 95  VAL   A O   1 
ATOM   500  C  CB  . VAL   A 1 74  ? -2.978  -12.024 -13.349 1.00 76.75  ? 95  VAL   A CB  1 
ATOM   501  C  CG1 . VAL   A 1 74  ? -1.818  -12.672 -12.609 1.00 77.98  ? 95  VAL   A CG1 1 
ATOM   502  C  CG2 . VAL   A 1 74  ? -3.849  -13.079 -14.015 1.00 79.99  ? 95  VAL   A CG2 1 
ATOM   503  N  N   . LYS   A 1 75  ? -2.606  -9.088  -12.827 1.00 78.81  ? 96  LYS   A N   1 
ATOM   504  C  CA  . LYS   A 1 75  ? -1.640  -8.040  -12.502 1.00 77.61  ? 96  LYS   A CA  1 
ATOM   505  C  C   . LYS   A 1 75  ? -2.176  -7.079  -11.448 1.00 80.12  ? 96  LYS   A C   1 
ATOM   506  O  O   . LYS   A 1 75  ? -1.465  -6.730  -10.498 1.00 84.86  ? 96  LYS   A O   1 
ATOM   507  C  CB  . LYS   A 1 75  ? -1.252  -7.274  -13.767 1.00 78.71  ? 96  LYS   A CB  1 
ATOM   508  C  CG  . LYS   A 1 75  ? -0.625  -8.125  -14.858 1.00 81.58  ? 96  LYS   A CG  1 
ATOM   509  C  CD  . LYS   A 1 75  ? -0.219  -7.262  -16.043 1.00 84.52  ? 96  LYS   A CD  1 
ATOM   510  C  CE  . LYS   A 1 75  ? 0.262   -8.100  -17.216 1.00 86.86  ? 96  LYS   A CE  1 
ATOM   511  N  NZ  . LYS   A 1 75  ? 0.637   -7.244  -18.377 1.00 92.33  ? 96  LYS   A NZ  1 
ATOM   512  N  N   . GLU   A 1 76  ? -3.421  -6.639  -11.596 1.00 78.56  ? 97  GLU   A N   1 
ATOM   513  C  CA  . GLU   A 1 76  ? -4.019  -5.648  -10.711 1.00 78.50  ? 97  GLU   A CA  1 
ATOM   514  C  C   . GLU   A 1 76  ? -5.191  -6.241  -9.939  1.00 75.64  ? 97  GLU   A C   1 
ATOM   515  O  O   . GLU   A 1 76  ? -6.194  -5.571  -9.681  1.00 74.01  ? 97  GLU   A O   1 
ATOM   516  C  CB  . GLU   A 1 76  ? -4.456  -4.415  -11.499 1.00 80.12  ? 97  GLU   A CB  1 
ATOM   517  C  CG  . GLU   A 1 76  ? -3.320  -3.734  -12.249 1.00 82.32  ? 97  GLU   A CG  1 
ATOM   518  C  CD  . GLU   A 1 76  ? -2.204  -3.277  -11.327 1.00 86.00  ? 97  GLU   A CD  1 
ATOM   519  O  OE1 . GLU   A 1 76  ? -2.505  -2.608  -10.315 1.00 86.67  ? 97  GLU   A OE1 1 
ATOM   520  O  OE2 . GLU   A 1 76  ? -1.029  -3.595  -11.609 1.00 87.12  ? 97  GLU   A OE2 1 
ATOM   521  N  N   . CYS   A 1 77  ? -5.073  -7.515  -9.559  1.00 73.36  ? 98  CYS   A N   1 
ATOM   522  C  CA  . CYS   A 1 77  ? -6.153  -8.171  -8.831  1.00 73.02  ? 98  CYS   A CA  1 
ATOM   523  C  C   . CYS   A 1 77  ? -6.274  -7.626  -7.414  1.00 74.87  ? 98  CYS   A C   1 
ATOM   524  O  O   . CYS   A 1 77  ? -7.353  -7.190  -6.996  1.00 75.53  ? 98  CYS   A O   1 
ATOM   525  C  CB  . CYS   A 1 77  ? -5.927  -9.683  -8.809  1.00 74.55  ? 98  CYS   A CB  1 
ATOM   526  S  SG  . CYS   A 1 77  ? -7.081  -10.589 -7.752  1.00 74.16  ? 98  CYS   A SG  1 
ATOM   527  N  N   . TYR   A 1 78  ? -5.173  -7.632  -6.660  1.00 78.45  ? 99  TYR   A N   1 
ATOM   528  C  CA  . TYR   A 1 78  ? -5.232  -7.188  -5.272  1.00 75.67  ? 99  TYR   A CA  1 
ATOM   529  C  C   . TYR   A 1 78  ? -5.433  -5.683  -5.163  1.00 75.31  ? 99  TYR   A C   1 
ATOM   530  O  O   . TYR   A 1 78  ? -6.114  -5.215  -4.243  1.00 79.41  ? 99  TYR   A O   1 
ATOM   531  C  CB  . TYR   A 1 78  ? -3.960  -7.603  -4.532  1.00 77.36  ? 99  TYR   A CB  1 
ATOM   532  C  CG  . TYR   A 1 78  ? -3.780  -9.097  -4.416  1.00 76.09  ? 99  TYR   A CG  1 
ATOM   533  C  CD1 . TYR   A 1 78  ? -4.375  -9.808  -3.382  1.00 75.73  ? 99  TYR   A CD1 1 
ATOM   534  C  CD2 . TYR   A 1 78  ? -3.013  -9.797  -5.338  1.00 70.30  ? 99  TYR   A CD2 1 
ATOM   535  C  CE1 . TYR   A 1 78  ? -4.214  -11.173 -3.269  1.00 77.99  ? 99  TYR   A CE1 1 
ATOM   536  C  CE2 . TYR   A 1 78  ? -2.845  -11.164 -5.233  1.00 76.32  ? 99  TYR   A CE2 1 
ATOM   537  C  CZ  . TYR   A 1 78  ? -3.448  -11.847 -4.196  1.00 80.00  ? 99  TYR   A CZ  1 
ATOM   538  O  OH  . TYR   A 1 78  ? -3.288  -13.209 -4.082  1.00 77.93  ? 99  TYR   A OH  1 
ATOM   539  N  N   . SER   A 1 79  ? -4.852  -4.913  -6.084  1.00 73.34  ? 100 SER   A N   1 
ATOM   540  C  CA  . SER   A 1 79  ? -4.881  -3.460  -5.961  1.00 77.28  ? 100 SER   A CA  1 
ATOM   541  C  C   . SER   A 1 79  ? -6.201  -2.865  -6.440  1.00 79.59  ? 100 SER   A C   1 
ATOM   542  O  O   . SER   A 1 79  ? -6.705  -1.911  -5.837  1.00 78.80  ? 100 SER   A O   1 
ATOM   543  C  CB  . SER   A 1 79  ? -3.712  -2.851  -6.736  1.00 79.83  ? 100 SER   A CB  1 
ATOM   544  O  OG  . SER   A 1 79  ? -3.683  -3.326  -8.071  1.00 81.47  ? 100 SER   A OG  1 
ATOM   545  N  N   . VAL   A 1 80  ? -6.772  -3.399  -7.521  1.00 77.35  ? 101 VAL   A N   1 
ATOM   546  C  CA  . VAL   A 1 80  ? -7.934  -2.773  -8.146  1.00 78.13  ? 101 VAL   A CA  1 
ATOM   547  C  C   . VAL   A 1 80  ? -9.112  -3.735  -8.239  1.00 76.43  ? 101 VAL   A C   1 
ATOM   548  O  O   . VAL   A 1 80  ? -10.178 -3.488  -7.668  1.00 77.37  ? 101 VAL   A O   1 
ATOM   549  C  CB  . VAL   A 1 80  ? -7.581  -2.238  -9.545  1.00 80.63  ? 101 VAL   A CB  1 
ATOM   550  C  CG1 . VAL   A 1 80  ? -8.776  -1.512  -10.147 1.00 77.70  ? 101 VAL   A CG1 1 
ATOM   551  C  CG2 . VAL   A 1 80  ? -6.359  -1.335  -9.479  1.00 80.02  ? 101 VAL   A CG2 1 
ATOM   552  N  N   . PHE   A 1 81  ? -8.934  -4.829  -8.977  1.00 76.07  ? 102 PHE   A N   1 
ATOM   553  C  CA  . PHE   A 1 81  ? -10.036 -5.729  -9.316  1.00 71.78  ? 102 PHE   A CA  1 
ATOM   554  C  C   . PHE   A 1 81  ? -10.008 -6.920  -8.362  1.00 70.78  ? 102 PHE   A C   1 
ATOM   555  O  O   . PHE   A 1 81  ? -9.598  -8.028  -8.707  1.00 71.49  ? 102 PHE   A O   1 
ATOM   556  C  CB  . PHE   A 1 81  ? -9.932  -6.153  -10.776 1.00 73.66  ? 102 PHE   A CB  1 
ATOM   557  C  CG  . PHE   A 1 81  ? -9.717  -5.005  -11.721 1.00 74.41  ? 102 PHE   A CG  1 
ATOM   558  C  CD1 . PHE   A 1 81  ? -10.785 -4.236  -12.151 1.00 75.65  ? 102 PHE   A CD1 1 
ATOM   559  C  CD2 . PHE   A 1 81  ? -8.444  -4.688  -12.171 1.00 75.72  ? 102 PHE   A CD2 1 
ATOM   560  C  CE1 . PHE   A 1 81  ? -10.590 -3.175  -13.017 1.00 76.38  ? 102 PHE   A CE1 1 
ATOM   561  C  CE2 . PHE   A 1 81  ? -8.243  -3.629  -13.038 1.00 75.64  ? 102 PHE   A CE2 1 
ATOM   562  C  CZ  . PHE   A 1 81  ? -9.317  -2.872  -13.462 1.00 76.48  ? 102 PHE   A CZ  1 
ATOM   563  N  N   . THR   A 1 82  ? -10.471 -6.673  -7.137  1.00 72.47  ? 103 THR   A N   1 
ATOM   564  C  CA  . THR   A 1 82  ? -10.386 -7.647  -6.056  1.00 72.00  ? 103 THR   A CA  1 
ATOM   565  C  C   . THR   A 1 82  ? -11.704 -8.353  -5.767  1.00 69.42  ? 103 THR   A C   1 
ATOM   566  O  O   . THR   A 1 82  ? -11.689 -9.490  -5.284  1.00 67.73  ? 103 THR   A O   1 
ATOM   567  C  CB  . THR   A 1 82  ? -9.894  -6.962  -4.774  1.00 72.54  ? 103 THR   A CB  1 
ATOM   568  O  OG1 . THR   A 1 82  ? -8.795  -6.097  -5.087  1.00 78.38  ? 103 THR   A OG1 1 
ATOM   569  C  CG2 . THR   A 1 82  ? -9.435  -7.990  -3.747  1.00 73.85  ? 103 THR   A CG2 1 
ATOM   570  N  N   . ASN   A 1 83  ? -12.840 -7.724  -6.058  1.00 72.41  ? 104 ASN   A N   1 
ATOM   571  C  CA  . ASN   A 1 83  ? -14.134 -8.240  -5.638  1.00 71.45  ? 104 ASN   A CA  1 
ATOM   572  C  C   . ASN   A 1 83  ? -15.073 -8.360  -6.830  1.00 69.91  ? 104 ASN   A C   1 
ATOM   573  O  O   . ASN   A 1 83  ? -14.937 -7.644  -7.827  1.00 69.82  ? 104 ASN   A O   1 
ATOM   574  C  CB  . ASN   A 1 83  ? -14.763 -7.338  -4.564  1.00 71.06  ? 104 ASN   A CB  1 
ATOM   575  C  CG  . ASN   A 1 83  ? -13.784 -6.977  -3.460  1.00 72.99  ? 104 ASN   A CG  1 
ATOM   576  O  OD1 . ASN   A 1 83  ? -12.989 -7.809  -3.022  1.00 76.44  ? 104 ASN   A OD1 1 
ATOM   577  N  ND2 . ASN   A 1 83  ? -13.832 -5.727  -3.012  1.00 73.21  ? 104 ASN   A ND2 1 
ATOM   578  N  N   . ARG   A 1 84  ? -16.027 -9.281  -6.717  1.00 69.17  ? 105 ARG   A N   1 
ATOM   579  C  CA  . ARG   A 1 84  ? -17.061 -9.452  -7.722  1.00 69.39  ? 105 ARG   A CA  1 
ATOM   580  C  C   . ARG   A 1 84  ? -18.228 -8.513  -7.421  1.00 72.31  ? 105 ARG   A C   1 
ATOM   581  O  O   . ARG   A 1 84  ? -18.250 -7.816  -6.404  1.00 76.33  ? 105 ARG   A O   1 
ATOM   582  C  CB  . ARG   A 1 84  ? -17.511 -10.911 -7.779  1.00 72.20  ? 105 ARG   A CB  1 
ATOM   583  C  CG  . ARG   A 1 84  ? -16.377 -11.887 -8.044  1.00 73.56  ? 105 ARG   A CG  1 
ATOM   584  C  CD  . ARG   A 1 84  ? -16.895 -13.278 -8.368  1.00 71.13  ? 105 ARG   A CD  1 
ATOM   585  N  NE  . ARG   A 1 84  ? -15.808 -14.202 -8.669  1.00 66.42  ? 105 ARG   A NE  1 
ATOM   586  C  CZ  . ARG   A 1 84  ? -15.334 -15.102 -7.820  1.00 68.09  ? 105 ARG   A CZ  1 
ATOM   587  N  NH1 . ARG   A 1 84  ? -15.842 -15.241 -6.606  1.00 75.57  ? 105 ARG   A NH1 1 
ATOM   588  N  NH2 . ARG   A 1 84  ? -14.329 -15.887 -8.199  1.00 68.19  ? 105 ARG   A NH2 1 
ATOM   589  N  N   . ARG   A 1 85  ? -19.206 -8.486  -8.319  1.00 74.80  ? 106 ARG   A N   1 
ATOM   590  C  CA  . ARG   A 1 85  ? -20.348 -7.602  -8.143  1.00 74.67  ? 106 ARG   A CA  1 
ATOM   591  C  C   . ARG   A 1 85  ? -21.123 -7.993  -6.886  1.00 77.54  ? 106 ARG   A C   1 
ATOM   592  O  O   . ARG   A 1 85  ? -21.301 -9.187  -6.614  1.00 77.65  ? 106 ARG   A O   1 
ATOM   593  C  CB  . ARG   A 1 85  ? -21.255 -7.657  -9.375  1.00 72.42  ? 106 ARG   A CB  1 
ATOM   594  C  CG  . ARG   A 1 85  ? -22.635 -7.059  -9.179  1.00 74.95  ? 106 ARG   A CG  1 
ATOM   595  C  CD  . ARG   A 1 85  ? -23.166 -6.468  -10.472 1.00 76.71  ? 106 ARG   A CD  1 
ATOM   596  N  NE  . ARG   A 1 85  ? -22.972 -7.361  -11.608 1.00 70.17  ? 106 ARG   A NE  1 
ATOM   597  C  CZ  . ARG   A 1 85  ? -23.495 -7.164  -12.810 1.00 69.23  ? 106 ARG   A CZ  1 
ATOM   598  N  NH1 . ARG   A 1 85  ? -24.277 -6.127  -13.062 1.00 71.97  ? 106 ARG   A NH1 1 
ATOM   599  N  NH2 . ARG   A 1 85  ? -23.229 -8.031  -13.783 1.00 72.07  ? 106 ARG   A NH2 1 
ATOM   600  N  N   . PRO   A 1 86  ? -21.569 -7.023  -6.085  1.00 83.93  ? 107 PRO   A N   1 
ATOM   601  C  CA  . PRO   A 1 86  ? -22.321 -7.360  -4.869  1.00 84.79  ? 107 PRO   A CA  1 
ATOM   602  C  C   . PRO   A 1 86  ? -23.568 -8.168  -5.195  1.00 87.05  ? 107 PRO   A C   1 
ATOM   603  O  O   . PRO   A 1 86  ? -24.329 -7.835  -6.107  1.00 86.29  ? 107 PRO   A O   1 
ATOM   604  C  CB  . PRO   A 1 86  ? -22.670 -5.990  -4.273  1.00 82.72  ? 107 PRO   A CB  1 
ATOM   605  C  CG  . PRO   A 1 86  ? -22.516 -5.020  -5.407  1.00 82.61  ? 107 PRO   A CG  1 
ATOM   606  C  CD  . PRO   A 1 86  ? -21.402 -5.569  -6.242  1.00 82.85  ? 107 PRO   A CD  1 
ATOM   607  N  N   . PHE   A 1 87  ? -23.769 -9.237  -4.435  1.00 90.24  ? 108 PHE   A N   1 
ATOM   608  C  CA  . PHE   A 1 87  ? -24.875 -10.156 -4.640  1.00 95.89  ? 108 PHE   A CA  1 
ATOM   609  C  C   . PHE   A 1 87  ? -26.096 -9.692  -3.850  1.00 103.72 ? 108 PHE   A C   1 
ATOM   610  O  O   . PHE   A 1 87  ? -26.049 -8.723  -3.089  1.00 108.77 ? 108 PHE   A O   1 
ATOM   611  C  CB  . PHE   A 1 87  ? -24.455 -11.573 -4.237  1.00 98.22  ? 108 PHE   A CB  1 
ATOM   612  C  CG  . PHE   A 1 87  ? -25.410 -12.646 -4.679  1.00 101.78 ? 108 PHE   A CG  1 
ATOM   613  C  CD1 . PHE   A 1 87  ? -25.729 -12.803 -6.018  1.00 102.67 ? 108 PHE   A CD1 1 
ATOM   614  C  CD2 . PHE   A 1 87  ? -25.980 -13.503 -3.755  1.00 102.96 ? 108 PHE   A CD2 1 
ATOM   615  C  CE1 . PHE   A 1 87  ? -26.606 -13.792 -6.425  1.00 106.20 ? 108 PHE   A CE1 1 
ATOM   616  C  CE2 . PHE   A 1 87  ? -26.856 -14.493 -4.155  1.00 103.17 ? 108 PHE   A CE2 1 
ATOM   617  C  CZ  . PHE   A 1 87  ? -27.170 -14.638 -5.491  1.00 105.41 ? 108 PHE   A CZ  1 
ATOM   618  N  N   . GLY   A 1 88  ? -27.207 -10.396 -4.046  1.00 104.72 ? 109 GLY   A N   1 
ATOM   619  C  CA  . GLY   A 1 88  ? -28.438 -10.085 -3.364  1.00 104.14 ? 109 GLY   A CA  1 
ATOM   620  C  C   . GLY   A 1 88  ? -28.375 -10.398 -1.884  1.00 104.97 ? 109 GLY   A C   1 
ATOM   621  O  O   . GLY   A 1 88  ? -27.298 -10.497 -1.286  1.00 106.55 ? 109 GLY   A O   1 
ATOM   622  N  N   . PRO   A 1 89  ? -29.541 -10.559 -1.263  1.00 106.36 ? 110 PRO   A N   1 
ATOM   623  C  CA  . PRO   A 1 89  ? -29.587 -10.817 0.185   1.00 104.25 ? 110 PRO   A CA  1 
ATOM   624  C  C   . PRO   A 1 89  ? -28.907 -12.132 0.532   1.00 104.38 ? 110 PRO   A C   1 
ATOM   625  O  O   . PRO   A 1 89  ? -29.287 -13.197 0.042   1.00 105.43 ? 110 PRO   A O   1 
ATOM   626  C  CB  . PRO   A 1 89  ? -31.089 -10.855 0.486   1.00 106.40 ? 110 PRO   A CB  1 
ATOM   627  C  CG  . PRO   A 1 89  ? -31.733 -10.161 -0.676  1.00 109.23 ? 110 PRO   A CG  1 
ATOM   628  C  CD  . PRO   A 1 89  ? -30.883 -10.458 -1.855  1.00 109.42 ? 110 PRO   A CD  1 
ATOM   629  N  N   . VAL   A 1 90  ? -27.895 -12.051 1.396   1.00 104.76 ? 111 VAL   A N   1 
ATOM   630  C  CA  . VAL   A 1 90  ? -27.080 -13.213 1.732   1.00 103.52 ? 111 VAL   A CA  1 
ATOM   631  C  C   . VAL   A 1 90  ? -27.154 -13.511 3.224   1.00 102.83 ? 111 VAL   A C   1 
ATOM   632  O  O   . VAL   A 1 90  ? -26.982 -14.661 3.645   1.00 101.38 ? 111 VAL   A O   1 
ATOM   633  C  CB  . VAL   A 1 90  ? -25.621 -13.004 1.288   1.00 100.72 ? 111 VAL   A CB  1 
ATOM   634  C  CG1 . VAL   A 1 90  ? -25.506 -13.130 -0.219  1.00 99.06  ? 111 VAL   A CG1 1 
ATOM   635  C  CG2 . VAL   A 1 90  ? -25.120 -11.644 1.747   1.00 101.57 ? 111 VAL   A CG2 1 
ATOM   636  N  N   . GLY   A 1 91  ? -27.414 -12.487 4.031   1.00 105.46 ? 112 GLY   A N   1 
ATOM   637  C  CA  . GLY   A 1 91  ? -27.463 -12.691 5.471   1.00 104.44 ? 112 GLY   A CA  1 
ATOM   638  C  C   . GLY   A 1 91  ? -26.105 -13.085 6.021   1.00 99.28  ? 112 GLY   A C   1 
ATOM   639  O  O   . GLY   A 1 91  ? -25.079 -12.473 5.704   1.00 96.96  ? 112 GLY   A O   1 
ATOM   640  N  N   . PHE   A 1 92  ? -26.090 -14.126 6.858   1.00 100.84 ? 113 PHE   A N   1 
ATOM   641  C  CA  . PHE   A 1 92  ? -24.847 -14.588 7.468   1.00 100.67 ? 113 PHE   A CA  1 
ATOM   642  C  C   . PHE   A 1 92  ? -23.896 -15.219 6.460   1.00 99.27  ? 113 PHE   A C   1 
ATOM   643  O  O   . PHE   A 1 92  ? -22.716 -15.400 6.780   1.00 96.92  ? 113 PHE   A O   1 
ATOM   644  C  CB  . PHE   A 1 92  ? -25.144 -15.584 8.594   1.00 102.33 ? 113 PHE   A CB  1 
ATOM   645  C  CG  . PHE   A 1 92  ? -25.099 -17.026 8.164   1.00 102.10 ? 113 PHE   A CG  1 
ATOM   646  C  CD1 . PHE   A 1 92  ? -26.164 -17.595 7.486   1.00 105.81 ? 113 PHE   A CD1 1 
ATOM   647  C  CD2 . PHE   A 1 92  ? -23.996 -17.816 8.453   1.00 103.69 ? 113 PHE   A CD2 1 
ATOM   648  C  CE1 . PHE   A 1 92  ? -26.127 -18.920 7.092   1.00 104.57 ? 113 PHE   A CE1 1 
ATOM   649  C  CE2 . PHE   A 1 92  ? -23.952 -19.142 8.061   1.00 104.59 ? 113 PHE   A CE2 1 
ATOM   650  C  CZ  . PHE   A 1 92  ? -25.020 -19.695 7.381   1.00 104.15 ? 113 PHE   A CZ  1 
ATOM   651  N  N   . MET   A 1 93  ? -24.373 -15.555 5.261   1.00 101.86 ? 114 MET   A N   1 
ATOM   652  C  CA  . MET   A 1 93  ? -23.517 -16.104 4.216   1.00 97.23  ? 114 MET   A CA  1 
ATOM   653  C  C   . MET   A 1 93  ? -22.564 -15.074 3.624   1.00 91.59  ? 114 MET   A C   1 
ATOM   654  O  O   . MET   A 1 93  ? -21.833 -15.409 2.686   1.00 86.53  ? 114 MET   A O   1 
ATOM   655  C  CB  . MET   A 1 93  ? -24.374 -16.717 3.106   1.00 97.21  ? 114 MET   A CB  1 
ATOM   656  C  CG  . MET   A 1 93  ? -25.122 -17.973 3.526   1.00 102.30 ? 114 MET   A CG  1 
ATOM   657  S  SD  . MET   A 1 93  ? -24.015 -19.347 3.901   1.00 102.96 ? 114 MET   A SD  1 
ATOM   658  C  CE  . MET   A 1 93  ? -23.329 -19.682 2.281   1.00 98.40  ? 114 MET   A CE  1 
ATOM   659  N  N   . LYS   A 1 94  ? -22.551 -13.842 4.140   1.00 93.28  ? 115 LYS   A N   1 
ATOM   660  C  CA  . LYS   A 1 94  ? -21.598 -12.842 3.673   1.00 93.16  ? 115 LYS   A CA  1 
ATOM   661  C  C   . LYS   A 1 94  ? -20.160 -13.232 3.986   1.00 92.91  ? 115 LYS   A C   1 
ATOM   662  O  O   . LYS   A 1 94  ? -19.232 -12.664 3.399   1.00 88.97  ? 115 LYS   A O   1 
ATOM   663  C  CB  . LYS   A 1 94  ? -21.916 -11.480 4.291   1.00 94.63  ? 115 LYS   A CB  1 
ATOM   664  N  N   . SER   A 1 95  ? -19.955 -14.186 4.894   1.00 89.58  ? 116 SER   A N   1 
ATOM   665  C  CA  . SER   A 1 95  ? -18.624 -14.676 5.225   1.00 90.59  ? 116 SER   A CA  1 
ATOM   666  C  C   . SER   A 1 95  ? -18.127 -15.743 4.258   1.00 91.15  ? 116 SER   A C   1 
ATOM   667  O  O   . SER   A 1 95  ? -17.011 -16.241 4.435   1.00 88.52  ? 116 SER   A O   1 
ATOM   668  C  CB  . SER   A 1 95  ? -18.607 -15.229 6.654   1.00 95.83  ? 116 SER   A CB  1 
ATOM   669  O  OG  . SER   A 1 95  ? -18.855 -14.206 7.602   1.00 100.20 ? 116 SER   A OG  1 
ATOM   670  N  N   . ALA   A 1 96  ? -18.924 -16.113 3.258   1.00 89.60  ? 117 ALA   A N   1 
ATOM   671  C  CA  . ALA   A 1 96  ? -18.474 -17.062 2.251   1.00 83.72  ? 117 ALA   A CA  1 
ATOM   672  C  C   . ALA   A 1 96  ? -17.329 -16.472 1.435   1.00 85.92  ? 117 ALA   A C   1 
ATOM   673  O  O   . ALA   A 1 96  ? -17.274 -15.265 1.183   1.00 86.86  ? 117 ALA   A O   1 
ATOM   674  C  CB  . ALA   A 1 96  ? -19.631 -17.451 1.331   1.00 85.70  ? 117 ALA   A CB  1 
ATOM   675  N  N   . ILE   A 1 97  ? -16.402 -17.342 1.023   1.00 85.55  ? 118 ILE   A N   1 
ATOM   676  C  CA  . ILE   A 1 97  ? -15.218 -16.878 0.302   1.00 82.97  ? 118 ILE   A CA  1 
ATOM   677  C  C   . ILE   A 1 97  ? -15.589 -16.369 -1.086  1.00 81.24  ? 118 ILE   A C   1 
ATOM   678  O  O   . ILE   A 1 97  ? -14.931 -15.467 -1.619  1.00 80.22  ? 118 ILE   A O   1 
ATOM   679  C  CB  . ILE   A 1 97  ? -14.153 -17.993 0.236   1.00 84.73  ? 118 ILE   A CB  1 
ATOM   680  C  CG1 . ILE   A 1 97  ? -12.867 -17.481 -0.417  1.00 82.17  ? 118 ILE   A CG1 1 
ATOM   681  C  CG2 . ILE   A 1 97  ? -14.672 -19.208 -0.515  1.00 83.15  ? 118 ILE   A CG2 1 
ATOM   682  C  CD1 . ILE   A 1 97  ? -11.785 -18.533 -0.536  1.00 83.21  ? 118 ILE   A CD1 1 
ATOM   683  N  N   . SER   A 1 98  ? -16.646 -16.918 -1.689  1.00 81.50  ? 119 SER   A N   1 
ATOM   684  C  CA  . SER   A 1 98  ? -17.032 -16.520 -3.037  1.00 81.54  ? 119 SER   A CA  1 
ATOM   685  C  C   . SER   A 1 98  ? -17.604 -15.109 -3.102  1.00 82.59  ? 119 SER   A C   1 
ATOM   686  O  O   . SER   A 1 98  ? -17.697 -14.552 -4.202  1.00 81.71  ? 119 SER   A O   1 
ATOM   687  C  CB  . SER   A 1 98  ? -18.040 -17.521 -3.611  1.00 81.54  ? 119 SER   A CB  1 
ATOM   688  O  OG  . SER   A 1 98  ? -19.133 -17.718 -2.732  1.00 83.86  ? 119 SER   A OG  1 
ATOM   689  N  N   . ILE   A 1 99  ? -17.987 -14.515 -1.969  1.00 81.64  ? 120 ILE   A N   1 
ATOM   690  C  CA  . ILE   A 1 99  ? -18.491 -13.148 -1.945  1.00 85.66  ? 120 ILE   A CA  1 
ATOM   691  C  C   . ILE   A 1 99  ? -17.785 -12.272 -0.921  1.00 83.00  ? 120 ILE   A C   1 
ATOM   692  O  O   . ILE   A 1 99  ? -18.145 -11.103 -0.773  1.00 80.32  ? 120 ILE   A O   1 
ATOM   693  C  CB  . ILE   A 1 99  ? -20.017 -13.106 -1.712  1.00 84.54  ? 120 ILE   A CB  1 
ATOM   694  C  CG1 . ILE   A 1 99  ? -20.366 -13.637 -0.323  1.00 85.59  ? 120 ILE   A CG1 1 
ATOM   695  C  CG2 . ILE   A 1 99  ? -20.749 -13.890 -2.795  1.00 88.41  ? 120 ILE   A CG2 1 
ATOM   696  C  CD1 . ILE   A 1 99  ? -21.789 -13.345 0.087   1.00 89.95  ? 120 ILE   A CD1 1 
ATOM   697  N  N   . ALA   A 1 100 ? -16.794 -12.795 -0.201  1.00 80.34  ? 121 ALA   A N   1 
ATOM   698  C  CA  . ALA   A 1 100 ? -16.006 -11.962 0.693   1.00 80.73  ? 121 ALA   A CA  1 
ATOM   699  C  C   . ALA   A 1 100 ? -15.179 -10.965 -0.114  1.00 80.77  ? 121 ALA   A C   1 
ATOM   700  O  O   . ALA   A 1 100 ? -14.868 -11.183 -1.289  1.00 76.82  ? 121 ALA   A O   1 
ATOM   701  C  CB  . ALA   A 1 100 ? -15.096 -12.819 1.573   1.00 82.17  ? 121 ALA   A CB  1 
ATOM   702  N  N   . GLU   A 1 101 ? -14.823 -9.855  0.529   1.00 79.64  ? 122 GLU   A N   1 
ATOM   703  C  CA  . GLU   A 1 101 ? -14.220 -8.730  -0.170  1.00 75.14  ? 122 GLU   A CA  1 
ATOM   704  C  C   . GLU   A 1 101 ? -12.935 -8.276  0.507   1.00 79.36  ? 122 GLU   A C   1 
ATOM   705  O  O   . GLU   A 1 101 ? -12.832 -8.278  1.738   1.00 82.40  ? 122 GLU   A O   1 
ATOM   706  C  CB  . GLU   A 1 101 ? -15.201 -7.556  -0.255  1.00 72.77  ? 122 GLU   A CB  1 
ATOM   707  C  CG  . GLU   A 1 101 ? -16.482 -7.883  -1.003  1.00 75.59  ? 122 GLU   A CG  1 
ATOM   708  C  CD  . GLU   A 1 101 ? -17.504 -6.769  -0.929  1.00 77.99  ? 122 GLU   A CD  1 
ATOM   709  O  OE1 . GLU   A 1 101 ? -17.152 -5.668  -0.458  1.00 86.63  ? 122 GLU   A OE1 1 
ATOM   710  O  OE2 . GLU   A 1 101 ? -18.663 -6.997  -1.337  1.00 84.22  ? 122 GLU   A OE2 1 
ATOM   711  N  N   . ASP   A 1 102 ? -11.961 -7.894  -0.318  1.00 78.75  ? 123 ASP   A N   1 
ATOM   712  C  CA  . ASP   A 1 102 ? -10.741 -7.180  0.090   1.00 77.76  ? 123 ASP   A CA  1 
ATOM   713  C  C   . ASP   A 1 102 ? -9.971  -8.023  1.106   1.00 82.78  ? 123 ASP   A C   1 
ATOM   714  O  O   . ASP   A 1 102 ? -9.736  -9.214  0.846   1.00 83.61  ? 123 ASP   A O   1 
ATOM   715  C  CB  . ASP   A 1 102 ? -11.147 -5.787  0.556   1.00 79.68  ? 123 ASP   A CB  1 
ATOM   716  C  CG  . ASP   A 1 102 ? -11.784 -4.968  -0.551  1.00 77.70  ? 123 ASP   A CG  1 
ATOM   717  O  OD1 . ASP   A 1 102 ? -11.216 -4.919  -1.663  1.00 75.71  ? 123 ASP   A OD1 1 
ATOM   718  O  OD2 . ASP   A 1 102 ? -12.859 -4.378  -0.311  1.00 79.31  ? 123 ASP   A OD2 1 
ATOM   719  N  N   . GLU   A 1 103 ? -9.557  -7.463  2.248   1.00 87.66  ? 124 GLU   A N   1 
ATOM   720  C  CA  . GLU   A 1 103 ? -8.685  -8.191  3.168   1.00 87.40  ? 124 GLU   A CA  1 
ATOM   721  C  C   . GLU   A 1 103 ? -9.371  -9.431  3.721   1.00 88.78  ? 124 GLU   A C   1 
ATOM   722  O  O   . GLU   A 1 103 ? -8.721  -10.460 3.944   1.00 88.89  ? 124 GLU   A O   1 
ATOM   723  C  CB  . GLU   A 1 103 ? -8.240  -7.280  4.314   1.00 87.80  ? 124 GLU   A CB  1 
ATOM   724  C  CG  . GLU   A 1 103 ? -7.445  -6.056  3.886   1.00 89.61  ? 124 GLU   A CG  1 
ATOM   725  C  CD  . GLU   A 1 103 ? -8.331  -4.891  3.497   1.00 92.80  ? 124 GLU   A CD  1 
ATOM   726  O  OE1 . GLU   A 1 103 ? -9.568  -5.025  3.605   1.00 92.89  ? 124 GLU   A OE1 1 
ATOM   727  O  OE2 . GLU   A 1 103 ? -7.792  -3.841  3.086   1.00 95.41  ? 124 GLU   A OE2 1 
ATOM   728  N  N   . GLU   A 1 104 ? -10.681 -9.351  3.958   1.00 88.46  ? 125 GLU   A N   1 
ATOM   729  C  CA  . GLU   A 1 104 ? -11.394 -10.484 4.537   1.00 87.66  ? 125 GLU   A CA  1 
ATOM   730  C  C   . GLU   A 1 104 ? -11.366 -11.689 3.603   1.00 88.64  ? 125 GLU   A C   1 
ATOM   731  O  O   . GLU   A 1 104 ? -11.272 -12.833 4.060   1.00 89.67  ? 125 GLU   A O   1 
ATOM   732  C  CB  . GLU   A 1 104 ? -12.831 -10.080 4.875   1.00 89.23  ? 125 GLU   A CB  1 
ATOM   733  C  CG  . GLU   A 1 104 ? -12.973 -8.646  5.397   1.00 94.37  ? 125 GLU   A CG  1 
ATOM   734  C  CD  . GLU   A 1 104 ? -12.040 -8.326  6.558   1.00 99.08  ? 125 GLU   A CD  1 
ATOM   735  O  OE1 . GLU   A 1 104 ? -11.820 -9.206  7.417   1.00 100.29 ? 125 GLU   A OE1 1 
ATOM   736  O  OE2 . GLU   A 1 104 ? -11.521 -7.188  6.607   1.00 95.94  ? 125 GLU   A OE2 1 
ATOM   737  N  N   . TRP   A 1 105 ? -11.446 -11.453 2.289   1.00 86.52  ? 126 TRP   A N   1 
ATOM   738  C  CA  . TRP   A 1 105 ? -11.308 -12.551 1.336   1.00 83.91  ? 126 TRP   A CA  1 
ATOM   739  C  C   . TRP   A 1 105 ? -9.896  -13.122 1.344   1.00 85.40  ? 126 TRP   A C   1 
ATOM   740  O  O   . TRP   A 1 105 ? -9.717  -14.346 1.306   1.00 87.53  ? 126 TRP   A O   1 
ATOM   741  C  CB  . TRP   A 1 105 ? -11.677 -12.089 -0.074  1.00 80.80  ? 126 TRP   A CB  1 
ATOM   742  C  CG  . TRP   A 1 105 ? -11.185 -13.028 -1.142  1.00 80.77  ? 126 TRP   A CG  1 
ATOM   743  C  CD1 . TRP   A 1 105 ? -11.752 -14.212 -1.517  1.00 81.64  ? 126 TRP   A CD1 1 
ATOM   744  C  CD2 . TRP   A 1 105 ? -10.021 -12.864 -1.965  1.00 82.04  ? 126 TRP   A CD2 1 
ATOM   745  N  NE1 . TRP   A 1 105 ? -11.017 -14.793 -2.523  1.00 79.92  ? 126 TRP   A NE1 1 
ATOM   746  C  CE2 . TRP   A 1 105 ? -9.949  -13.986 -2.816  1.00 80.72  ? 126 TRP   A CE2 1 
ATOM   747  C  CE3 . TRP   A 1 105 ? -9.035  -11.877 -2.066  1.00 81.08  ? 126 TRP   A CE3 1 
ATOM   748  C  CZ2 . TRP   A 1 105 ? -8.930  -14.148 -3.754  1.00 79.38  ? 126 TRP   A CZ2 1 
ATOM   749  C  CZ3 . TRP   A 1 105 ? -8.024  -12.040 -2.999  1.00 78.11  ? 126 TRP   A CZ3 1 
ATOM   750  C  CH2 . TRP   A 1 105 ? -7.980  -13.166 -3.830  1.00 79.46  ? 126 TRP   A CH2 1 
ATOM   751  N  N   . LYS   A 1 106 ? -8.882  -12.253 1.387   1.00 84.04  ? 127 LYS   A N   1 
ATOM   752  C  CA  . LYS   A 1 106 ? -7.500  -12.722 1.348   1.00 83.87  ? 127 LYS   A CA  1 
ATOM   753  C  C   . LYS   A 1 106 ? -7.195  -13.626 2.535   1.00 88.30  ? 127 LYS   A C   1 
ATOM   754  O  O   . LYS   A 1 106 ? -6.461  -14.613 2.402   1.00 86.84  ? 127 LYS   A O   1 
ATOM   755  C  CB  . LYS   A 1 106 ? -6.540  -11.533 1.318   1.00 80.65  ? 127 LYS   A CB  1 
ATOM   756  N  N   . ARG   A 1 107 ? -7.745  -13.300 3.706   1.00 86.52  ? 128 ARG   A N   1 
ATOM   757  C  CA  . ARG   A 1 107 ? -7.596  -14.178 4.860   1.00 88.90  ? 128 ARG   A CA  1 
ATOM   758  C  C   . ARG   A 1 107 ? -8.291  -15.515 4.629   1.00 90.81  ? 128 ARG   A C   1 
ATOM   759  O  O   . ARG   A 1 107 ? -7.730  -16.573 4.937   1.00 93.70  ? 128 ARG   A O   1 
ATOM   760  C  CB  . ARG   A 1 107 ? -8.146  -13.495 6.110   1.00 89.46  ? 128 ARG   A CB  1 
ATOM   761  C  CG  . ARG   A 1 107 ? -7.931  -14.289 7.384   1.00 93.65  ? 128 ARG   A CG  1 
ATOM   762  C  CD  . ARG   A 1 107 ? -8.548  -13.591 8.579   1.00 94.85  ? 128 ARG   A CD  1 
ATOM   763  N  NE  . ARG   A 1 107 ? -9.999  -13.503 8.470   1.00 99.13  ? 128 ARG   A NE  1 
ATOM   764  C  CZ  . ARG   A 1 107 ? -10.838 -14.447 8.873   1.00 100.39 ? 128 ARG   A CZ  1 
ATOM   765  N  NH1 . ARG   A 1 107 ? -10.403 -15.574 9.413   1.00 98.95  ? 128 ARG   A NH1 1 
ATOM   766  N  NH2 . ARG   A 1 107 ? -12.146 -14.257 8.730   1.00 99.96  ? 128 ARG   A NH2 1 
ATOM   767  N  N   . LEU   A 1 108 ? -9.508  -15.489 4.081   1.00 89.35  ? 129 LEU   A N   1 
ATOM   768  C  CA  . LEU   A 1 108 ? -10.247 -16.728 3.860   1.00 87.19  ? 129 LEU   A CA  1 
ATOM   769  C  C   . LEU   A 1 108 ? -9.598  -17.579 2.775   1.00 86.71  ? 129 LEU   A C   1 
ATOM   770  O  O   . LEU   A 1 108 ? -9.551  -18.809 2.891   1.00 89.21  ? 129 LEU   A O   1 
ATOM   771  C  CB  . LEU   A 1 108 ? -11.699 -16.415 3.503   1.00 85.84  ? 129 LEU   A CB  1 
ATOM   772  C  CG  . LEU   A 1 108 ? -12.505 -15.737 4.612   1.00 87.61  ? 129 LEU   A CG  1 
ATOM   773  C  CD1 . LEU   A 1 108 ? -13.917 -15.429 4.145   1.00 87.60  ? 129 LEU   A CD1 1 
ATOM   774  C  CD2 . LEU   A 1 108 ? -12.522 -16.597 5.867   1.00 91.44  ? 129 LEU   A CD2 1 
ATOM   775  N  N   . ARG   A 1 109 ? -9.101  -16.946 1.710   1.00 85.70  ? 130 ARG   A N   1 
ATOM   776  C  CA  . ARG   A 1 109 ? -8.436  -17.700 0.652   1.00 87.67  ? 130 ARG   A CA  1 
ATOM   777  C  C   . ARG   A 1 109 ? -7.192  -18.404 1.180   1.00 91.16  ? 130 ARG   A C   1 
ATOM   778  O  O   . ARG   A 1 109 ? -6.951  -19.575 0.864   1.00 93.30  ? 130 ARG   A O   1 
ATOM   779  C  CB  . ARG   A 1 109 ? -8.073  -16.773 -0.508  1.00 84.05  ? 130 ARG   A CB  1 
ATOM   780  C  CG  . ARG   A 1 109 ? -7.479  -17.487 -1.714  1.00 79.86  ? 130 ARG   A CG  1 
ATOM   781  C  CD  . ARG   A 1 109 ? -8.557  -17.919 -2.698  1.00 81.00  ? 130 ARG   A CD  1 
ATOM   782  N  NE  . ARG   A 1 109 ? -8.006  -18.683 -3.812  1.00 79.38  ? 130 ARG   A NE  1 
ATOM   783  C  CZ  . ARG   A 1 109 ? -8.650  -18.930 -4.945  1.00 73.02  ? 130 ARG   A CZ  1 
ATOM   784  N  NH1 . ARG   A 1 109 ? -9.871  -18.469 -5.161  1.00 74.14  ? 130 ARG   A NH1 1 
ATOM   785  N  NH2 . ARG   A 1 109 ? -8.051  -19.652 -5.887  1.00 68.74  ? 130 ARG   A NH2 1 
ATOM   786  N  N   . SER   A 1 110 ? -6.392  -17.706 1.988   1.00 92.82  ? 131 SER   A N   1 
ATOM   787  C  CA  . SER   A 1 110 ? -5.185  -18.314 2.538   1.00 91.04  ? 131 SER   A CA  1 
ATOM   788  C  C   . SER   A 1 110 ? -5.526  -19.405 3.546   1.00 91.79  ? 131 SER   A C   1 
ATOM   789  O  O   . SER   A 1 110 ? -4.854  -20.441 3.598   1.00 96.59  ? 131 SER   A O   1 
ATOM   790  C  CB  . SER   A 1 110 ? -4.305  -17.243 3.181   1.00 90.61  ? 131 SER   A CB  1 
ATOM   791  O  OG  . SER   A 1 110 ? -2.989  -17.725 3.391   1.00 90.69  ? 131 SER   A OG  1 
ATOM   792  N  N   . LEU   A 1 111 ? -6.562  -19.187 4.359   1.00 91.87  ? 132 LEU   A N   1 
ATOM   793  C  CA  . LEU   A 1 111 ? -6.963  -20.189 5.340   1.00 93.27  ? 132 LEU   A CA  1 
ATOM   794  C  C   . LEU   A 1 111 ? -7.523  -21.449 4.693   1.00 92.24  ? 132 LEU   A C   1 
ATOM   795  O  O   . LEU   A 1 111 ? -7.483  -22.517 5.313   1.00 93.97  ? 132 LEU   A O   1 
ATOM   796  C  CB  . LEU   A 1 111 ? -7.994  -19.603 6.309   1.00 94.13  ? 132 LEU   A CB  1 
ATOM   797  C  CG  . LEU   A 1 111 ? -7.474  -18.651 7.389   1.00 96.26  ? 132 LEU   A CG  1 
ATOM   798  C  CD1 . LEU   A 1 111 ? -8.587  -18.283 8.359   1.00 100.37 ? 132 LEU   A CD1 1 
ATOM   799  C  CD2 . LEU   A 1 111 ? -6.296  -19.264 8.129   1.00 98.81  ? 132 LEU   A CD2 1 
ATOM   800  N  N   . LEU   A 1 112 ? -8.043  -21.355 3.470   1.00 94.25  ? 133 LEU   A N   1 
ATOM   801  C  CA  . LEU   A 1 112 ? -8.640  -22.498 2.793   1.00 95.55  ? 133 LEU   A CA  1 
ATOM   802  C  C   . LEU   A 1 112 ? -7.812  -23.012 1.624   1.00 96.16  ? 133 LEU   A C   1 
ATOM   803  O  O   . LEU   A 1 112 ? -8.188  -24.019 1.014   1.00 95.21  ? 133 LEU   A O   1 
ATOM   804  C  CB  . LEU   A 1 112 ? -10.053 -22.149 2.312   1.00 86.49  ? 133 LEU   A CB  1 
ATOM   805  C  CG  . LEU   A 1 112 ? -11.110 -22.166 3.415   1.00 91.70  ? 133 LEU   A CG  1 
ATOM   806  C  CD1 . LEU   A 1 112 ? -12.501 -21.958 2.841   1.00 95.23  ? 133 LEU   A CD1 1 
ATOM   807  C  CD2 . LEU   A 1 112 ? -11.031 -23.474 4.187   1.00 95.63  ? 133 LEU   A CD2 1 
ATOM   808  N  N   . SER   A 1 113 ? -6.703  -22.352 1.292   1.00 94.59  ? 134 SER   A N   1 
ATOM   809  C  CA  . SER   A 1 113 ? -5.844  -22.841 0.215   1.00 94.00  ? 134 SER   A CA  1 
ATOM   810  C  C   . SER   A 1 113 ? -5.259  -24.222 0.494   1.00 98.66  ? 134 SER   A C   1 
ATOM   811  O  O   . SER   A 1 113 ? -5.301  -25.075 -0.410  1.00 99.24  ? 134 SER   A O   1 
ATOM   812  C  CB  . SER   A 1 113 ? -4.745  -21.813 -0.073  1.00 94.75  ? 134 SER   A CB  1 
ATOM   813  O  OG  . SER   A 1 113 ? -5.291  -20.625 -0.622  1.00 94.35  ? 134 SER   A OG  1 
ATOM   814  N  N   . PRO   A 1 114 ? -4.706  -24.520 1.679   1.00 98.35  ? 135 PRO   A N   1 
ATOM   815  C  CA  . PRO   A 1 114 ? -4.143  -25.866 1.896   1.00 98.46  ? 135 PRO   A CA  1 
ATOM   816  C  C   . PRO   A 1 114 ? -5.161  -26.987 1.781   1.00 96.99  ? 135 PRO   A C   1 
ATOM   817  O  O   . PRO   A 1 114 ? -4.768  -28.135 1.537   1.00 100.61 ? 135 PRO   A O   1 
ATOM   818  C  CB  . PRO   A 1 114 ? -3.567  -25.783 3.316   1.00 102.46 ? 135 PRO   A CB  1 
ATOM   819  C  CG  . PRO   A 1 114 ? -3.311  -24.341 3.533   1.00 99.06  ? 135 PRO   A CG  1 
ATOM   820  C  CD  . PRO   A 1 114 ? -4.427  -23.637 2.827   1.00 98.36  ? 135 PRO   A CD  1 
ATOM   821  N  N   . THR   A 1 115 ? -6.451  -26.696 1.951   1.00 95.57  ? 136 THR   A N   1 
ATOM   822  C  CA  . THR   A 1 115 ? -7.474  -27.728 1.836   1.00 99.64  ? 136 THR   A CA  1 
ATOM   823  C  C   . THR   A 1 115 ? -7.588  -28.276 0.418   1.00 96.97  ? 136 THR   A C   1 
ATOM   824  O  O   . THR   A 1 115 ? -8.077  -29.396 0.235   1.00 96.37  ? 136 THR   A O   1 
ATOM   825  C  CB  . THR   A 1 115 ? -8.824  -27.172 2.295   1.00 97.91  ? 136 THR   A CB  1 
ATOM   826  O  OG1 . THR   A 1 115 ? -8.641  -26.395 3.485   1.00 98.13  ? 136 THR   A OG1 1 
ATOM   827  C  CG2 . THR   A 1 115 ? -9.798  -28.299 2.594   1.00 98.34  ? 136 THR   A CG2 1 
ATOM   828  N  N   . PHE   A 1 116 ? -7.132  -27.525 -0.586  1.00 95.58  ? 137 PHE   A N   1 
ATOM   829  C  CA  . PHE   A 1 116 ? -7.269  -27.918 -1.982  1.00 98.90  ? 137 PHE   A CA  1 
ATOM   830  C  C   . PHE   A 1 116 ? -5.929  -28.233 -2.640  1.00 100.61 ? 137 PHE   A C   1 
ATOM   831  O  O   . PHE   A 1 116 ? -5.807  -28.131 -3.865  1.00 98.25  ? 137 PHE   A O   1 
ATOM   832  C  CB  . PHE   A 1 116 ? -7.997  -26.827 -2.769  1.00 97.67  ? 137 PHE   A CB  1 
ATOM   833  C  CG  . PHE   A 1 116 ? -9.414  -26.597 -2.323  1.00 92.26  ? 137 PHE   A CG  1 
ATOM   834  C  CD1 . PHE   A 1 116 ? -9.700  -25.681 -1.324  1.00 91.40  ? 137 PHE   A CD1 1 
ATOM   835  C  CD2 . PHE   A 1 116 ? -10.461 -27.293 -2.907  1.00 91.68  ? 137 PHE   A CD2 1 
ATOM   836  C  CE1 . PHE   A 1 116 ? -11.003 -25.465 -0.912  1.00 89.24  ? 137 PHE   A CE1 1 
ATOM   837  C  CE2 . PHE   A 1 116 ? -11.765 -27.082 -2.499  1.00 93.48  ? 137 PHE   A CE2 1 
ATOM   838  C  CZ  . PHE   A 1 116 ? -12.037 -26.166 -1.501  1.00 89.78  ? 137 PHE   A CZ  1 
ATOM   839  N  N   . THR   A 1 117 ? -4.923  -28.614 -1.857  1.00 101.10 ? 138 THR   A N   1 
ATOM   840  C  CA  . THR   A 1 117 ? -3.633  -28.959 -2.433  1.00 99.99  ? 138 THR   A CA  1 
ATOM   841  C  C   . THR   A 1 117 ? -3.717  -30.281 -3.191  1.00 101.40 ? 138 THR   A C   1 
ATOM   842  O  O   . THR   A 1 117 ? -4.615  -31.101 -2.972  1.00 102.84 ? 138 THR   A O   1 
ATOM   843  C  CB  . THR   A 1 117 ? -2.561  -29.055 -1.348  1.00 99.05  ? 138 THR   A CB  1 
ATOM   844  O  OG1 . THR   A 1 117 ? -2.974  -29.994 -0.348  1.00 98.31  ? 138 THR   A OG1 1 
ATOM   845  C  CG2 . THR   A 1 117 ? -2.333  -27.700 -0.704  1.00 97.13  ? 138 THR   A CG2 1 
ATOM   846  N  N   . SER   A 1 118 ? -2.761  -30.478 -4.101  1.00 102.39 ? 139 SER   A N   1 
ATOM   847  C  CA  . SER   A 1 118 ? -2.699  -31.728 -4.850  1.00 102.64 ? 139 SER   A CA  1 
ATOM   848  C  C   . SER   A 1 118 ? -2.451  -32.909 -3.921  1.00 104.31 ? 139 SER   A C   1 
ATOM   849  O  O   . SER   A 1 118 ? -3.012  -33.993 -4.119  1.00 105.94 ? 139 SER   A O   1 
ATOM   850  C  CB  . SER   A 1 118 ? -1.613  -31.646 -5.923  1.00 105.19 ? 139 SER   A CB  1 
ATOM   851  O  OG  . SER   A 1 118 ? -0.346  -31.378 -5.350  1.00 106.53 ? 139 SER   A OG  1 
ATOM   852  N  N   . GLY   A 1 119 ? -1.610  -32.719 -2.902  1.00 103.44 ? 140 GLY   A N   1 
ATOM   853  C  CA  . GLY   A 1 119 ? -1.378  -33.783 -1.940  1.00 105.63 ? 140 GLY   A CA  1 
ATOM   854  C  C   . GLY   A 1 119 ? -2.623  -34.137 -1.146  1.00 105.34 ? 140 GLY   A C   1 
ATOM   855  O  O   . GLY   A 1 119 ? -2.930  -35.315 -0.949  1.00 106.23 ? 140 GLY   A O   1 
ATOM   856  N  N   . LYS   A 1 120 ? -3.356  -33.122 -0.679  1.00 103.19 ? 141 LYS   A N   1 
ATOM   857  C  CA  . LYS   A 1 120 ? -4.597  -33.376 0.043   1.00 102.14 ? 141 LYS   A CA  1 
ATOM   858  C  C   . LYS   A 1 120 ? -5.699  -33.894 -0.870  1.00 103.31 ? 141 LYS   A C   1 
ATOM   859  O  O   . LYS   A 1 120 ? -6.637  -34.535 -0.386  1.00 104.41 ? 141 LYS   A O   1 
ATOM   860  C  CB  . LYS   A 1 120 ? -5.072  -32.108 0.754   1.00 98.40  ? 141 LYS   A CB  1 
ATOM   861  N  N   . LEU   A 1 121 ? -5.613  -33.625 -2.173  1.00 102.62 ? 142 LEU   A N   1 
ATOM   862  C  CA  . LEU   A 1 121 ? -6.605  -34.151 -3.103  1.00 102.22 ? 142 LEU   A CA  1 
ATOM   863  C  C   . LEU   A 1 121 ? -6.407  -35.642 -3.345  1.00 105.50 ? 142 LEU   A C   1 
ATOM   864  O  O   . LEU   A 1 121 ? -7.379  -36.359 -3.613  1.00 106.78 ? 142 LEU   A O   1 
ATOM   865  C  CB  . LEU   A 1 121 ? -6.544  -33.378 -4.422  1.00 101.32 ? 142 LEU   A CB  1 
ATOM   866  C  CG  . LEU   A 1 121 ? -7.461  -33.837 -5.558  1.00 96.76  ? 142 LEU   A CG  1 
ATOM   867  C  CD1 . LEU   A 1 121 ? -8.912  -33.846 -5.110  1.00 96.03  ? 142 LEU   A CD1 1 
ATOM   868  C  CD2 . LEU   A 1 121 ? -7.279  -32.949 -6.778  1.00 95.10  ? 142 LEU   A CD2 1 
ATOM   869  N  N   . LYS   A 1 122 ? -5.164  -36.121 -3.263  1.00 106.22 ? 143 LYS   A N   1 
ATOM   870  C  CA  . LYS   A 1 122 ? -4.903  -37.544 -3.460  1.00 106.90 ? 143 LYS   A CA  1 
ATOM   871  C  C   . LYS   A 1 122 ? -5.680  -38.386 -2.459  1.00 108.65 ? 143 LYS   A C   1 
ATOM   872  O  O   . LYS   A 1 122 ? -6.301  -39.392 -2.821  1.00 112.41 ? 143 LYS   A O   1 
ATOM   873  C  CB  . LYS   A 1 122 ? -3.407  -37.832 -3.339  1.00 107.51 ? 143 LYS   A CB  1 
ATOM   874  C  CG  . LYS   A 1 122 ? -2.541  -37.194 -4.406  1.00 107.92 ? 143 LYS   A CG  1 
ATOM   875  C  CD  . LYS   A 1 122 ? -1.188  -37.882 -4.472  1.00 106.17 ? 143 LYS   A CD  1 
ATOM   876  C  CE  . LYS   A 1 122 ? -1.354  -39.390 -4.535  1.00 107.27 ? 143 LYS   A CE  1 
ATOM   877  N  NZ  . LYS   A 1 122 ? -0.467  -39.989 -5.563  1.00 107.95 ? 143 LYS   A NZ  1 
ATOM   878  N  N   . GLU   A 1 123 ? -5.661  -37.984 -1.188  1.00 105.56 ? 144 GLU   A N   1 
ATOM   879  C  CA  . GLU   A 1 123 ? -6.318  -38.762 -0.141  1.00 107.80 ? 144 GLU   A CA  1 
ATOM   880  C  C   . GLU   A 1 123 ? -7.832  -38.823 -0.325  1.00 112.06 ? 144 GLU   A C   1 
ATOM   881  O  O   . GLU   A 1 123 ? -8.478  -39.715 0.233   1.00 112.83 ? 144 GLU   A O   1 
ATOM   882  C  CB  . GLU   A 1 123 ? -5.978  -38.172 1.226   1.00 109.92 ? 144 GLU   A CB  1 
ATOM   883  C  CG  . GLU   A 1 123 ? -4.505  -37.794 1.388   1.00 112.94 ? 144 GLU   A CG  1 
ATOM   884  C  CD  . GLU   A 1 123 ? -4.056  -37.778 2.838   1.00 120.40 ? 144 GLU   A CD  1 
ATOM   885  O  OE1 . GLU   A 1 123 ? -3.956  -38.870 3.438   1.00 121.76 ? 144 GLU   A OE1 1 
ATOM   886  O  OE2 . GLU   A 1 123 ? -3.808  -36.676 3.375   1.00 122.10 ? 144 GLU   A OE2 1 
ATOM   887  N  N   . MET   A 1 124 ? -8.409  -37.895 -1.089  1.00 110.70 ? 145 MET   A N   1 
ATOM   888  C  CA  . MET   A 1 124 ? -9.836  -37.913 -1.363  1.00 112.33 ? 145 MET   A CA  1 
ATOM   889  C  C   . MET   A 1 124 ? -10.229 -38.875 -2.478  1.00 113.75 ? 145 MET   A C   1 
ATOM   890  O  O   . MET   A 1 124 ? -11.420 -39.176 -2.617  1.00 113.51 ? 145 MET   A O   1 
ATOM   891  C  CB  . MET   A 1 124 ? -10.307 -36.504 -1.719  1.00 108.86 ? 145 MET   A CB  1 
ATOM   892  C  CG  . MET   A 1 124 ? -10.122 -35.488 -0.603  1.00 108.24 ? 145 MET   A CG  1 
ATOM   893  S  SD  . MET   A 1 124 ? -11.100 -33.995 -0.857  1.00 105.76 ? 145 MET   A SD  1 
ATOM   894  C  CE  . MET   A 1 124 ? -11.779 -33.768 0.783   1.00 106.94 ? 145 MET   A CE  1 
ATOM   895  N  N   . VAL   A 1 125 ? -9.267  -39.359 -3.268  1.00 112.74 ? 146 VAL   A N   1 
ATOM   896  C  CA  . VAL   A 1 125 ? -9.593  -40.277 -4.364  1.00 113.27 ? 146 VAL   A CA  1 
ATOM   897  C  C   . VAL   A 1 125 ? -10.258 -41.559 -3.871  1.00 115.63 ? 146 VAL   A C   1 
ATOM   898  O  O   . VAL   A 1 125 ? -11.284 -41.955 -4.449  1.00 115.62 ? 146 VAL   A O   1 
ATOM   899  C  CB  . VAL   A 1 125 ? -8.341  -40.547 -5.216  1.00 112.22 ? 146 VAL   A CB  1 
ATOM   900  C  CG1 . VAL   A 1 125 ? -8.565  -41.739 -6.133  1.00 112.14 ? 146 VAL   A CG1 1 
ATOM   901  C  CG2 . VAL   A 1 125 ? -7.978  -39.310 -6.021  1.00 111.20 ? 146 VAL   A CG2 1 
ATOM   902  N  N   . PRO   A 1 126 ? -9.745  -42.256 -2.844  1.00 116.46 ? 147 PRO   A N   1 
ATOM   903  C  CA  . PRO   A 1 126 ? -10.426 -43.492 -2.413  1.00 115.54 ? 147 PRO   A CA  1 
ATOM   904  C  C   . PRO   A 1 126 ? -11.881 -43.282 -2.024  1.00 115.32 ? 147 PRO   A C   1 
ATOM   905  O  O   . PRO   A 1 126 ? -12.724 -44.139 -2.315  1.00 116.03 ? 147 PRO   A O   1 
ATOM   906  C  CB  . PRO   A 1 126 ? -9.580  -43.957 -1.220  1.00 114.97 ? 147 PRO   A CB  1 
ATOM   907  C  CG  . PRO   A 1 126 ? -8.235  -43.387 -1.475  1.00 112.30 ? 147 PRO   A CG  1 
ATOM   908  C  CD  . PRO   A 1 126 ? -8.488  -42.049 -2.099  1.00 113.61 ? 147 PRO   A CD  1 
ATOM   909  N  N   . ILE   A 1 127 ? -12.199 -42.162 -1.372  1.00 114.75 ? 148 ILE   A N   1 
ATOM   910  C  CA  . ILE   A 1 127 ? -13.587 -41.882 -1.016  1.00 116.60 ? 148 ILE   A CA  1 
ATOM   911  C  C   . ILE   A 1 127 ? -14.407 -41.558 -2.261  1.00 117.64 ? 148 ILE   A C   1 
ATOM   912  O  O   . ILE   A 1 127 ? -15.547 -42.017 -2.407  1.00 117.57 ? 148 ILE   A O   1 
ATOM   913  C  CB  . ILE   A 1 127 ? -13.650 -40.748 0.023   1.00 115.14 ? 148 ILE   A CB  1 
ATOM   914  C  CG1 . ILE   A 1 127 ? -13.096 -41.222 1.369   1.00 115.26 ? 148 ILE   A CG1 1 
ATOM   915  C  CG2 . ILE   A 1 127 ? -15.073 -40.247 0.185   1.00 116.09 ? 148 ILE   A CG2 1 
ATOM   916  C  CD1 . ILE   A 1 127 ? -13.974 -42.242 2.067   1.00 117.75 ? 148 ILE   A CD1 1 
ATOM   917  N  N   . ILE   A 1 128 ? -13.844 -40.764 -3.176  1.00 116.24 ? 149 ILE   A N   1 
ATOM   918  C  CA  . ILE   A 1 128 ? -14.561 -40.418 -4.401  1.00 114.76 ? 149 ILE   A CA  1 
ATOM   919  C  C   . ILE   A 1 128 ? -14.789 -41.656 -5.261  1.00 118.01 ? 149 ILE   A C   1 
ATOM   920  O  O   . ILE   A 1 128 ? -15.892 -41.874 -5.778  1.00 117.22 ? 149 ILE   A O   1 
ATOM   921  C  CB  . ILE   A 1 128 ? -13.806 -39.322 -5.176  1.00 112.27 ? 149 ILE   A CB  1 
ATOM   922  C  CG1 . ILE   A 1 128 ? -13.874 -37.990 -4.428  1.00 109.67 ? 149 ILE   A CG1 1 
ATOM   923  C  CG2 . ILE   A 1 128 ? -14.370 -39.172 -6.580  1.00 109.99 ? 149 ILE   A CG2 1 
ATOM   924  C  CD1 . ILE   A 1 128 ? -13.276 -36.834 -5.198  1.00 104.82 ? 149 ILE   A CD1 1 
ATOM   925  N  N   . ALA   A 1 129 ? -13.757 -42.489 -5.424  1.00 119.51 ? 150 ALA   A N   1 
ATOM   926  C  CA  . ALA   A 1 129 ? -13.900 -43.701 -6.223  1.00 120.31 ? 150 ALA   A CA  1 
ATOM   927  C  C   . ALA   A 1 129 ? -14.878 -44.687 -5.603  1.00 120.05 ? 150 ALA   A C   1 
ATOM   928  O  O   . ALA   A 1 129 ? -15.387 -45.566 -6.308  1.00 120.73 ? 150 ALA   A O   1 
ATOM   929  C  CB  . ALA   A 1 129 ? -12.539 -44.370 -6.417  1.00 118.80 ? 150 ALA   A CB  1 
ATOM   930  N  N   . GLN   A 1 130 ? -15.150 -44.561 -4.301  1.00 118.86 ? 151 GLN   A N   1 
ATOM   931  C  CA  . GLN   A 1 130 ? -16.120 -45.435 -3.651  1.00 119.62 ? 151 GLN   A CA  1 
ATOM   932  C  C   . GLN   A 1 130 ? -17.511 -45.255 -4.245  1.00 120.38 ? 151 GLN   A C   1 
ATOM   933  O  O   . GLN   A 1 130 ? -18.260 -46.227 -4.400  1.00 121.65 ? 151 GLN   A O   1 
ATOM   934  C  CB  . GLN   A 1 130 ? -16.138 -45.163 -2.147  1.00 119.28 ? 151 GLN   A CB  1 
ATOM   935  C  CG  . GLN   A 1 130 ? -17.321 -45.765 -1.412  1.00 119.80 ? 151 GLN   A CG  1 
ATOM   936  C  CD  . GLN   A 1 130 ? -17.379 -45.334 0.039   1.00 122.55 ? 151 GLN   A CD  1 
ATOM   937  O  OE1 . GLN   A 1 130 ? -16.460 -44.687 0.542   1.00 122.67 ? 151 GLN   A OE1 1 
ATOM   938  N  NE2 . GLN   A 1 130 ? -18.463 -45.688 0.719   1.00 123.39 ? 151 GLN   A NE2 1 
ATOM   939  N  N   . TYR   A 1 131 ? -17.878 -44.022 -4.578  1.00 120.87 ? 152 TYR   A N   1 
ATOM   940  C  CA  . TYR   A 1 131 ? -19.175 -43.747 -5.179  1.00 120.93 ? 152 TYR   A CA  1 
ATOM   941  C  C   . TYR   A 1 131 ? -19.144 -43.806 -6.698  1.00 119.16 ? 152 TYR   A C   1 
ATOM   942  O  O   . TYR   A 1 131 ? -20.192 -43.646 -7.332  1.00 118.73 ? 152 TYR   A O   1 
ATOM   943  C  CB  . TYR   A 1 131 ? -19.691 -42.388 -4.705  1.00 119.20 ? 152 TYR   A CB  1 
ATOM   944  C  CG  . TYR   A 1 131 ? -19.792 -42.330 -3.204  1.00 118.86 ? 152 TYR   A CG  1 
ATOM   945  C  CD1 . TYR   A 1 131 ? -20.889 -42.866 -2.542  1.00 120.23 ? 152 TYR   A CD1 1 
ATOM   946  C  CD2 . TYR   A 1 131 ? -18.773 -41.775 -2.445  1.00 117.70 ? 152 TYR   A CD2 1 
ATOM   947  C  CE1 . TYR   A 1 131 ? -20.977 -42.829 -1.166  1.00 120.11 ? 152 TYR   A CE1 1 
ATOM   948  C  CE2 . TYR   A 1 131 ? -18.851 -41.735 -1.073  1.00 120.06 ? 152 TYR   A CE2 1 
ATOM   949  C  CZ  . TYR   A 1 131 ? -19.952 -42.262 -0.438  1.00 120.20 ? 152 TYR   A CZ  1 
ATOM   950  O  OH  . TYR   A 1 131 ? -20.019 -42.216 0.931   1.00 118.97 ? 152 TYR   A OH  1 
ATOM   951  N  N   . GLY   A 1 132 ? -17.971 -44.024 -7.294  1.00 120.12 ? 153 GLY   A N   1 
ATOM   952  C  CA  . GLY   A 1 132 ? -17.932 -44.368 -8.704  1.00 120.23 ? 153 GLY   A CA  1 
ATOM   953  C  C   . GLY   A 1 132 ? -18.600 -45.701 -8.980  1.00 119.66 ? 153 GLY   A C   1 
ATOM   954  O  O   . GLY   A 1 132 ? -19.363 -45.837 -9.940  1.00 118.64 ? 153 GLY   A O   1 
ATOM   955  N  N   . ASP   A 1 133 ? -18.332 -46.701 -8.134  1.00 120.80 ? 154 ASP   A N   1 
ATOM   956  C  CA  . ASP   A 1 133 ? -18.995 -47.992 -8.283  1.00 123.56 ? 154 ASP   A CA  1 
ATOM   957  C  C   . ASP   A 1 133 ? -20.454 -47.924 -7.852  1.00 121.42 ? 154 ASP   A C   1 
ATOM   958  O  O   . ASP   A 1 133 ? -21.286 -48.680 -8.367  1.00 120.27 ? 154 ASP   A O   1 
ATOM   959  C  CB  . ASP   A 1 133 ? -18.251 -49.070 -7.491  1.00 123.11 ? 154 ASP   A CB  1 
ATOM   960  C  CG  . ASP   A 1 133 ? -18.170 -48.763 -6.008  1.00 124.88 ? 154 ASP   A CG  1 
ATOM   961  O  OD1 . ASP   A 1 133 ? -19.218 -48.804 -5.327  1.00 125.46 ? 154 ASP   A OD1 1 
ATOM   962  O  OD2 . ASP   A 1 133 ? -17.054 -48.489 -5.518  1.00 125.89 ? 154 ASP   A OD2 1 
ATOM   963  N  N   . VAL   A 1 134 ? -20.781 -47.039 -6.907  1.00 120.56 ? 155 VAL   A N   1 
ATOM   964  C  CA  . VAL   A 1 134 ? -22.179 -46.823 -6.545  1.00 119.61 ? 155 VAL   A CA  1 
ATOM   965  C  C   . VAL   A 1 134 ? -22.952 -46.286 -7.741  1.00 117.14 ? 155 VAL   A C   1 
ATOM   966  O  O   . VAL   A 1 134 ? -24.096 -46.685 -7.995  1.00 118.43 ? 155 VAL   A O   1 
ATOM   967  C  CB  . VAL   A 1 134 ? -22.281 -45.881 -5.330  1.00 120.26 ? 155 VAL   A CB  1 
ATOM   968  C  CG1 . VAL   A 1 134 ? -23.738 -45.603 -4.986  1.00 121.45 ? 155 VAL   A CG1 1 
ATOM   969  C  CG2 . VAL   A 1 134 ? -21.552 -46.475 -4.133  1.00 117.57 ? 155 VAL   A CG2 1 
ATOM   970  N  N   . LEU   A 1 135 ? -22.337 -45.376 -8.500  1.00 117.17 ? 156 LEU   A N   1 
ATOM   971  C  CA  . LEU   A 1 135 ? -22.973 -44.859 -9.707  1.00 118.45 ? 156 LEU   A CA  1 
ATOM   972  C  C   . LEU   A 1 135 ? -23.118 -45.945 -10.767 1.00 119.89 ? 156 LEU   A C   1 
ATOM   973  O  O   . LEU   A 1 135 ? -24.104 -45.964 -11.512 1.00 118.85 ? 156 LEU   A O   1 
ATOM   974  C  CB  . LEU   A 1 135 ? -22.172 -43.677 -10.252 1.00 115.15 ? 156 LEU   A CB  1 
ATOM   975  C  CG  . LEU   A 1 135 ? -22.743 -42.975 -11.484 1.00 112.64 ? 156 LEU   A CG  1 
ATOM   976  C  CD1 . LEU   A 1 135 ? -24.154 -42.482 -11.207 1.00 110.69 ? 156 LEU   A CD1 1 
ATOM   977  C  CD2 . LEU   A 1 135 ? -21.843 -41.825 -11.906 1.00 109.91 ? 156 LEU   A CD2 1 
ATOM   978  N  N   . VAL   A 1 136 ? -22.142 -46.853 -10.854 1.00 120.96 ? 157 VAL   A N   1 
ATOM   979  C  CA  . VAL   A 1 136 ? -22.213 -47.937 -11.832 1.00 120.79 ? 157 VAL   A CA  1 
ATOM   980  C  C   . VAL   A 1 136 ? -23.408 -48.838 -11.544 1.00 120.71 ? 157 VAL   A C   1 
ATOM   981  O  O   . VAL   A 1 136 ? -24.155 -49.219 -12.454 1.00 120.38 ? 157 VAL   A O   1 
ATOM   982  C  CB  . VAL   A 1 136 ? -20.896 -48.735 -11.847 1.00 119.07 ? 157 VAL   A CB  1 
ATOM   983  C  CG1 . VAL   A 1 136 ? -21.056 -50.012 -12.660 1.00 119.12 ? 157 VAL   A CG1 1 
ATOM   984  C  CG2 . VAL   A 1 136 ? -19.768 -47.885 -12.408 1.00 117.96 ? 157 VAL   A CG2 1 
ATOM   985  N  N   . ARG   A 1 137 ? -23.606 -49.191 -10.271 1.00 120.47 ? 158 ARG   A N   1 
ATOM   986  C  CA  . ARG   A 1 137 ? -24.737 -50.040 -9.905  1.00 119.12 ? 158 ARG   A CA  1 
ATOM   987  C  C   . ARG   A 1 137 ? -26.062 -49.352 -10.206 1.00 120.23 ? 158 ARG   A C   1 
ATOM   988  O  O   . ARG   A 1 137 ? -27.008 -49.990 -10.682 1.00 119.75 ? 158 ARG   A O   1 
ATOM   989  C  CB  . ARG   A 1 137 ? -24.652 -50.419 -8.426  1.00 113.10 ? 158 ARG   A CB  1 
ATOM   990  N  N   . ASN   A 1 138 ? -26.148 -48.048 -9.934  1.00 120.83 ? 159 ASN   A N   1 
ATOM   991  C  CA  . ASN   A 1 138 ? -27.363 -47.306 -10.247 1.00 121.94 ? 159 ASN   A CA  1 
ATOM   992  C  C   . ASN   A 1 138 ? -27.613 -47.238 -11.748 1.00 122.47 ? 159 ASN   A C   1 
ATOM   993  O  O   . ASN   A 1 138 ? -28.770 -47.251 -12.183 1.00 122.80 ? 159 ASN   A O   1 
ATOM   994  C  CB  . ASN   A 1 138 ? -27.283 -45.898 -9.657  1.00 121.16 ? 159 ASN   A CB  1 
ATOM   995  C  CG  . ASN   A 1 138 ? -27.348 -45.897 -8.141  1.00 122.10 ? 159 ASN   A CG  1 
ATOM   996  O  OD1 . ASN   A 1 138 ? -27.789 -46.868 -7.526  1.00 122.90 ? 159 ASN   A OD1 1 
ATOM   997  N  ND2 . ASN   A 1 138 ? -26.916 -44.799 -7.531  1.00 121.46 ? 159 ASN   A ND2 1 
ATOM   998  N  N   . LEU   A 1 139 ? -26.549 -47.155 -12.549 1.00 122.01 ? 160 LEU   A N   1 
ATOM   999  C  CA  . LEU   A 1 139 ? -26.708 -47.132 -13.999 1.00 119.96 ? 160 LEU   A CA  1 
ATOM   1000 C  C   . LEU   A 1 139 ? -27.050 -48.512 -14.549 1.00 121.84 ? 160 LEU   A C   1 
ATOM   1001 O  O   . LEU   A 1 139 ? -27.862 -48.629 -15.473 1.00 124.73 ? 160 LEU   A O   1 
ATOM   1002 C  CB  . LEU   A 1 139 ? -25.438 -46.593 -14.660 1.00 118.03 ? 160 LEU   A CB  1 
ATOM   1003 N  N   . ARG   A 1 140 ? -26.445 -49.563 -13.990 1.00 120.62 ? 161 ARG   A N   1 
ATOM   1004 C  CA  . ARG   A 1 140 ? -26.688 -50.917 -14.481 1.00 122.25 ? 161 ARG   A CA  1 
ATOM   1005 C  C   . ARG   A 1 140 ? -28.125 -51.355 -14.231 1.00 123.26 ? 161 ARG   A C   1 
ATOM   1006 O  O   . ARG   A 1 140 ? -28.698 -52.086 -15.047 1.00 123.12 ? 161 ARG   A O   1 
ATOM   1007 C  CB  . ARG   A 1 140 ? -25.702 -51.886 -13.829 1.00 123.00 ? 161 ARG   A CB  1 
ATOM   1008 C  CG  . ARG   A 1 140 ? -25.541 -53.219 -14.542 1.00 122.07 ? 161 ARG   A CG  1 
ATOM   1009 C  CD  . ARG   A 1 140 ? -24.255 -53.910 -14.107 1.00 119.47 ? 161 ARG   A CD  1 
ATOM   1010 N  NE  . ARG   A 1 140 ? -23.106 -53.483 -14.897 1.00 118.72 ? 161 ARG   A NE  1 
ATOM   1011 C  CZ  . ARG   A 1 140 ? -21.845 -53.573 -14.496 1.00 123.03 ? 161 ARG   A CZ  1 
ATOM   1012 N  NH1 . ARG   A 1 140 ? -21.532 -54.022 -13.292 1.00 127.79 ? 161 ARG   A NH1 1 
ATOM   1013 N  NH2 . ARG   A 1 140 ? -20.873 -53.196 -15.322 1.00 120.56 ? 161 ARG   A NH2 1 
ATOM   1014 N  N   . ARG   A 1 141 ? -28.722 -50.921 -13.117 1.00 124.81 ? 162 ARG   A N   1 
ATOM   1015 C  CA  . ARG   A 1 141 ? -30.125 -51.227 -12.859 1.00 122.90 ? 162 ARG   A CA  1 
ATOM   1016 C  C   . ARG   A 1 141 ? -31.039 -50.562 -13.879 1.00 123.16 ? 162 ARG   A C   1 
ATOM   1017 O  O   . ARG   A 1 141 ? -32.097 -51.107 -14.208 1.00 126.08 ? 162 ARG   A O   1 
ATOM   1018 C  CB  . ARG   A 1 141 ? -30.504 -50.796 -11.443 1.00 120.97 ? 162 ARG   A CB  1 
ATOM   1019 N  N   . GLU   A 1 142 ? -30.655 -49.390 -14.383 1.00 122.29 ? 163 GLU   A N   1 
ATOM   1020 C  CA  . GLU   A 1 142 ? -31.403 -48.722 -15.438 1.00 122.14 ? 163 GLU   A CA  1 
ATOM   1021 C  C   . GLU   A 1 142 ? -30.943 -49.118 -16.835 1.00 123.68 ? 163 GLU   A C   1 
ATOM   1022 O  O   . GLU   A 1 142 ? -31.653 -48.835 -17.806 1.00 124.29 ? 163 GLU   A O   1 
ATOM   1023 C  CB  . GLU   A 1 142 ? -31.299 -47.202 -15.278 1.00 120.69 ? 163 GLU   A CB  1 
ATOM   1024 N  N   . ALA   A 1 143 ? -29.781 -49.761 -16.961 1.00 123.44 ? 164 ALA   A N   1 
ATOM   1025 C  CA  . ALA   A 1 143 ? -29.281 -50.207 -18.256 1.00 124.11 ? 164 ALA   A CA  1 
ATOM   1026 C  C   . ALA   A 1 143 ? -29.741 -51.617 -18.600 1.00 127.64 ? 164 ALA   A C   1 
ATOM   1027 O  O   . ALA   A 1 143 ? -30.111 -51.883 -19.749 1.00 127.48 ? 164 ALA   A O   1 
ATOM   1028 C  CB  . ALA   A 1 143 ? -27.752 -50.139 -18.289 1.00 122.59 ? 164 ALA   A CB  1 
ATOM   1029 N  N   . GLU   A 1 144 ? -29.724 -52.531 -17.624 1.00 130.11 ? 165 GLU   A N   1 
ATOM   1030 C  CA  . GLU   A 1 144 ? -30.229 -53.879 -17.857 1.00 130.53 ? 165 GLU   A CA  1 
ATOM   1031 C  C   . GLU   A 1 144 ? -31.723 -53.892 -18.147 1.00 131.82 ? 165 GLU   A C   1 
ATOM   1032 O  O   . GLU   A 1 144 ? -32.224 -54.869 -18.714 1.00 135.05 ? 165 GLU   A O   1 
ATOM   1033 C  CB  . GLU   A 1 144 ? -29.923 -54.776 -16.654 1.00 127.74 ? 165 GLU   A CB  1 
ATOM   1034 C  CG  . GLU   A 1 144 ? -28.447 -55.107 -16.482 1.00 128.44 ? 165 GLU   A CG  1 
ATOM   1035 C  CD  . GLU   A 1 144 ? -28.171 -55.922 -15.233 1.00 123.89 ? 165 GLU   A CD  1 
ATOM   1036 O  OE1 . GLU   A 1 144 ? -29.055 -55.979 -14.352 1.00 124.32 ? 165 GLU   A OE1 1 
ATOM   1037 O  OE2 . GLU   A 1 144 ? -27.072 -56.506 -15.133 1.00 122.32 ? 165 GLU   A OE2 1 
ATOM   1038 N  N   . THR   A 1 145 ? -32.442 -52.835 -17.773 1.00 128.70 ? 166 THR   A N   1 
ATOM   1039 C  CA  . THR   A 1 145 ? -33.858 -52.700 -18.085 1.00 130.67 ? 166 THR   A CA  1 
ATOM   1040 C  C   . THR   A 1 145 ? -34.110 -51.886 -19.347 1.00 131.28 ? 166 THR   A C   1 
ATOM   1041 O  O   . THR   A 1 145 ? -35.272 -51.675 -19.708 1.00 132.75 ? 166 THR   A O   1 
ATOM   1042 C  CB  . THR   A 1 145 ? -34.601 -52.064 -16.905 1.00 132.29 ? 166 THR   A CB  1 
ATOM   1043 O  OG1 . THR   A 1 145 ? -34.113 -50.734 -16.691 1.00 131.10 ? 166 THR   A OG1 1 
ATOM   1044 C  CG2 . THR   A 1 145 ? -34.391 -52.887 -15.643 1.00 132.14 ? 166 THR   A CG2 1 
ATOM   1045 N  N   . GLY   A 1 146 ? -33.057 -51.418 -20.017 1.00 128.99 ? 167 GLY   A N   1 
ATOM   1046 C  CA  . GLY   A 1 146 ? -33.219 -50.676 -21.254 1.00 127.75 ? 167 GLY   A CA  1 
ATOM   1047 C  C   . GLY   A 1 146 ? -33.956 -49.366 -21.113 1.00 130.70 ? 167 GLY   A C   1 
ATOM   1048 O  O   . GLY   A 1 146 ? -34.456 -48.835 -22.108 1.00 128.20 ? 167 GLY   A O   1 
ATOM   1049 N  N   . LYS   A 1 147 ? -34.048 -48.831 -19.903 1.00 131.63 ? 168 LYS   A N   1 
ATOM   1050 C  CA  . LYS   A 1 147 ? -34.787 -47.596 -19.676 1.00 128.62 ? 168 LYS   A CA  1 
ATOM   1051 C  C   . LYS   A 1 147 ? -33.925 -46.393 -20.042 1.00 126.56 ? 168 LYS   A C   1 
ATOM   1052 O  O   . LYS   A 1 147 ? -32.769 -46.316 -19.614 1.00 124.72 ? 168 LYS   A O   1 
ATOM   1053 C  CB  . LYS   A 1 147 ? -35.231 -47.497 -18.219 1.00 127.47 ? 168 LYS   A CB  1 
ATOM   1054 N  N   . PRO   A 1 148 ? -34.436 -45.458 -20.845 1.00 126.08 ? 169 PRO   A N   1 
ATOM   1055 C  CA  . PRO   A 1 148 ? -33.692 -44.219 -21.095 1.00 124.43 ? 169 PRO   A CA  1 
ATOM   1056 C  C   . PRO   A 1 148 ? -33.391 -43.497 -19.789 1.00 123.49 ? 169 PRO   A C   1 
ATOM   1057 O  O   . PRO   A 1 148 ? -34.237 -43.406 -18.897 1.00 122.30 ? 169 PRO   A O   1 
ATOM   1058 C  CB  . PRO   A 1 148 ? -34.641 -43.409 -21.985 1.00 121.58 ? 169 PRO   A CB  1 
ATOM   1059 C  CG  . PRO   A 1 148 ? -35.501 -44.434 -22.644 1.00 122.24 ? 169 PRO   A CG  1 
ATOM   1060 C  CD  . PRO   A 1 148 ? -35.682 -45.525 -21.627 1.00 125.66 ? 169 PRO   A CD  1 
ATOM   1061 N  N   . VAL   A 1 149 ? -32.171 -42.978 -19.688 1.00 118.97 ? 170 VAL   A N   1 
ATOM   1062 C  CA  . VAL   A 1 149 ? -31.638 -42.434 -18.444 1.00 115.59 ? 170 VAL   A CA  1 
ATOM   1063 C  C   . VAL   A 1 149 ? -31.480 -40.929 -18.587 1.00 113.79 ? 170 VAL   A C   1 
ATOM   1064 O  O   . VAL   A 1 149 ? -30.837 -40.451 -19.529 1.00 114.85 ? 170 VAL   A O   1 
ATOM   1065 C  CB  . VAL   A 1 149 ? -30.295 -43.092 -18.079 1.00 113.78 ? 170 VAL   A CB  1 
ATOM   1066 C  CG1 . VAL   A 1 149 ? -29.559 -42.261 -17.041 1.00 109.85 ? 170 VAL   A CG1 1 
ATOM   1067 C  CG2 . VAL   A 1 149 ? -30.520 -44.506 -17.573 1.00 117.42 ? 170 VAL   A CG2 1 
ATOM   1068 N  N   . THR   A 1 150 ? -32.066 -40.184 -17.652 1.00 111.76 ? 171 THR   A N   1 
ATOM   1069 C  CA  . THR   A 1 150 ? -31.809 -38.753 -17.540 1.00 109.93 ? 171 THR   A CA  1 
ATOM   1070 C  C   . THR   A 1 150 ? -30.519 -38.566 -16.751 1.00 110.08 ? 171 THR   A C   1 
ATOM   1071 O  O   . THR   A 1 150 ? -30.460 -38.883 -15.558 1.00 110.09 ? 171 THR   A O   1 
ATOM   1072 C  CB  . THR   A 1 150 ? -32.977 -38.041 -16.863 1.00 108.75 ? 171 THR   A CB  1 
ATOM   1073 O  OG1 . THR   A 1 150 ? -34.131 -38.103 -17.710 1.00 107.70 ? 171 THR   A OG1 1 
ATOM   1074 C  CG2 . THR   A 1 150 ? -32.629 -36.583 -16.594 1.00 108.10 ? 171 THR   A CG2 1 
ATOM   1075 N  N   . LEU   A 1 151 ? -29.480 -38.060 -17.421 1.00 107.52 ? 172 LEU   A N   1 
ATOM   1076 C  CA  . LEU   A 1 151 ? -28.180 -37.908 -16.777 1.00 106.57 ? 172 LEU   A CA  1 
ATOM   1077 C  C   . LEU   A 1 151 ? -28.250 -36.967 -15.583 1.00 106.42 ? 172 LEU   A C   1 
ATOM   1078 O  O   . LEU   A 1 151 ? -27.496 -37.133 -14.618 1.00 106.44 ? 172 LEU   A O   1 
ATOM   1079 C  CB  . LEU   A 1 151 ? -27.153 -37.402 -17.789 1.00 106.32 ? 172 LEU   A CB  1 
ATOM   1080 C  CG  . LEU   A 1 151 ? -27.171 -38.097 -19.150 1.00 101.97 ? 172 LEU   A CG  1 
ATOM   1081 C  CD1 . LEU   A 1 151 ? -26.209 -37.419 -20.108 1.00 97.60  ? 172 LEU   A CD1 1 
ATOM   1082 C  CD2 . LEU   A 1 151 ? -26.841 -39.575 -19.006 1.00 100.83 ? 172 LEU   A CD2 1 
ATOM   1083 N  N   . LYS   A 1 152 ? -29.152 -35.983 -15.626 1.00 105.99 ? 173 LYS   A N   1 
ATOM   1084 C  CA  . LYS   A 1 152 ? -29.240 -35.002 -14.549 1.00 105.33 ? 173 LYS   A CA  1 
ATOM   1085 C  C   . LYS   A 1 152 ? -29.575 -35.656 -13.214 1.00 105.32 ? 173 LYS   A C   1 
ATOM   1086 O  O   . LYS   A 1 152 ? -29.133 -35.179 -12.162 1.00 103.71 ? 173 LYS   A O   1 
ATOM   1087 C  CB  . LYS   A 1 152 ? -30.281 -33.939 -14.901 1.00 105.59 ? 173 LYS   A CB  1 
ATOM   1088 C  CG  . LYS   A 1 152 ? -30.289 -32.737 -13.973 1.00 108.54 ? 173 LYS   A CG  1 
ATOM   1089 C  CD  . LYS   A 1 152 ? -31.311 -31.704 -14.420 1.00 106.09 ? 173 LYS   A CD  1 
ATOM   1090 C  CE  . LYS   A 1 152 ? -32.716 -32.279 -14.406 1.00 97.06  ? 173 LYS   A CE  1 
ATOM   1091 N  NZ  . LYS   A 1 152 ? -33.106 -32.752 -13.049 1.00 97.33  ? 173 LYS   A NZ  1 
ATOM   1092 N  N   . ASP   A 1 153 ? -30.342 -36.747 -13.232 1.00 105.92 ? 174 ASP   A N   1 
ATOM   1093 C  CA  . ASP   A 1 153 ? -30.700 -37.420 -11.989 1.00 105.47 ? 174 ASP   A CA  1 
ATOM   1094 C  C   . ASP   A 1 153 ? -29.549 -38.270 -11.463 1.00 106.73 ? 174 ASP   A C   1 
ATOM   1095 O  O   . ASP   A 1 153 ? -29.180 -38.170 -10.288 1.00 108.06 ? 174 ASP   A O   1 
ATOM   1096 C  CB  . ASP   A 1 153 ? -31.948 -38.281 -12.198 1.00 105.22 ? 174 ASP   A CB  1 
ATOM   1097 N  N   . VAL   A 1 154 ? -28.971 -39.115 -12.321 1.00 107.52 ? 175 VAL   A N   1 
ATOM   1098 C  CA  . VAL   A 1 154 ? -27.919 -40.025 -11.875 1.00 107.93 ? 175 VAL   A CA  1 
ATOM   1099 C  C   . VAL   A 1 154 ? -26.630 -39.265 -11.575 1.00 108.15 ? 175 VAL   A C   1 
ATOM   1100 O  O   . VAL   A 1 154 ? -25.966 -39.526 -10.565 1.00 109.96 ? 175 VAL   A O   1 
ATOM   1101 C  CB  . VAL   A 1 154 ? -27.702 -41.143 -12.911 1.00 108.22 ? 175 VAL   A CB  1 
ATOM   1102 C  CG1 . VAL   A 1 154 ? -28.824 -42.169 -12.821 1.00 109.54 ? 175 VAL   A CG1 1 
ATOM   1103 C  CG2 . VAL   A 1 154 ? -27.626 -40.569 -14.316 1.00 107.56 ? 175 VAL   A CG2 1 
ATOM   1104 N  N   . PHE   A 1 155 ? -26.248 -38.324 -12.443 1.00 107.93 ? 176 PHE   A N   1 
ATOM   1105 C  CA  . PHE   A 1 155 ? -25.059 -37.518 -12.175 1.00 108.16 ? 176 PHE   A CA  1 
ATOM   1106 C  C   . PHE   A 1 155 ? -25.278 -36.589 -10.988 1.00 109.44 ? 176 PHE   A C   1 
ATOM   1107 O  O   . PHE   A 1 155 ? -24.366 -36.385 -10.177 1.00 110.35 ? 176 PHE   A O   1 
ATOM   1108 C  CB  . PHE   A 1 155 ? -24.663 -36.719 -13.416 1.00 101.47 ? 176 PHE   A CB  1 
ATOM   1109 C  CG  . PHE   A 1 155 ? -23.903 -37.519 -14.434 1.00 102.01 ? 176 PHE   A CG  1 
ATOM   1110 C  CD1 . PHE   A 1 155 ? -23.097 -38.575 -14.041 1.00 101.65 ? 176 PHE   A CD1 1 
ATOM   1111 C  CD2 . PHE   A 1 155 ? -23.994 -37.217 -15.782 1.00 100.45 ? 176 PHE   A CD2 1 
ATOM   1112 C  CE1 . PHE   A 1 155 ? -22.394 -39.314 -14.973 1.00 97.08  ? 176 PHE   A CE1 1 
ATOM   1113 C  CE2 . PHE   A 1 155 ? -23.295 -37.951 -16.719 1.00 97.66  ? 176 PHE   A CE2 1 
ATOM   1114 C  CZ  . PHE   A 1 155 ? -22.493 -39.002 -16.314 1.00 97.20  ? 176 PHE   A CZ  1 
ATOM   1115 N  N   . GLY   A 1 156 ? -26.474 -36.009 -10.874 1.00 108.23 ? 177 GLY   A N   1 
ATOM   1116 C  CA  . GLY   A 1 156 ? -26.791 -35.226 -9.692  1.00 109.31 ? 177 GLY   A CA  1 
ATOM   1117 C  C   . GLY   A 1 156 ? -26.734 -36.056 -8.425  1.00 111.15 ? 177 GLY   A C   1 
ATOM   1118 O  O   . GLY   A 1 156 ? -26.321 -35.571 -7.369  1.00 113.91 ? 177 GLY   A O   1 
ATOM   1119 N  N   . ALA   A 1 157 ? -27.150 -37.321 -8.514  1.00 110.84 ? 178 ALA   A N   1 
ATOM   1120 C  CA  . ALA   A 1 157 ? -27.021 -38.223 -7.376  1.00 114.02 ? 178 ALA   A CA  1 
ATOM   1121 C  C   . ALA   A 1 157 ? -25.559 -38.519 -7.067  1.00 112.59 ? 178 ALA   A C   1 
ATOM   1122 O  O   . ALA   A 1 157 ? -25.162 -38.558 -5.896  1.00 112.35 ? 178 ALA   A O   1 
ATOM   1123 C  CB  . ALA   A 1 157 ? -27.787 -39.516 -7.644  1.00 114.95 ? 178 ALA   A CB  1 
ATOM   1124 N  N   . TYR   A 1 158 ? -24.742 -38.736 -8.102  1.00 112.51 ? 179 TYR   A N   1 
ATOM   1125 C  CA  . TYR   A 1 158 ? -23.324 -39.000 -7.882  1.00 111.87 ? 179 TYR   A CA  1 
ATOM   1126 C  C   . TYR   A 1 158 ? -22.622 -37.797 -7.264  1.00 112.07 ? 179 TYR   A C   1 
ATOM   1127 O  O   . TYR   A 1 158 ? -21.831 -37.949 -6.326  1.00 112.11 ? 179 TYR   A O   1 
ATOM   1128 C  CB  . TYR   A 1 158 ? -22.646 -39.389 -9.196  1.00 109.38 ? 179 TYR   A CB  1 
ATOM   1129 C  CG  . TYR   A 1 158 ? -21.136 -39.342 -9.127  1.00 110.63 ? 179 TYR   A CG  1 
ATOM   1130 C  CD1 . TYR   A 1 158 ? -20.412 -40.402 -8.595  1.00 111.96 ? 179 TYR   A CD1 1 
ATOM   1131 C  CD2 . TYR   A 1 158 ? -20.433 -38.235 -9.586  1.00 107.52 ? 179 TYR   A CD2 1 
ATOM   1132 C  CE1 . TYR   A 1 158 ? -19.030 -40.361 -8.525  1.00 111.99 ? 179 TYR   A CE1 1 
ATOM   1133 C  CE2 . TYR   A 1 158 ? -19.055 -38.183 -9.516  1.00 104.39 ? 179 TYR   A CE2 1 
ATOM   1134 C  CZ  . TYR   A 1 158 ? -18.357 -39.250 -8.989  1.00 106.52 ? 179 TYR   A CZ  1 
ATOM   1135 O  OH  . TYR   A 1 158 ? -16.982 -39.201 -8.922  1.00 102.20 ? 179 TYR   A OH  1 
ATOM   1136 N  N   . SER   A 1 159 ? -22.893 -36.596 -7.781  1.00 111.07 ? 180 SER   A N   1 
ATOM   1137 C  CA  . SER   A 1 159 ? -22.231 -35.403 -7.263  1.00 111.76 ? 180 SER   A CA  1 
ATOM   1138 C  C   . SER   A 1 159 ? -22.590 -35.158 -5.805  1.00 113.53 ? 180 SER   A C   1 
ATOM   1139 O  O   . SER   A 1 159 ? -21.757 -34.669 -5.034  1.00 113.32 ? 180 SER   A O   1 
ATOM   1140 C  CB  . SER   A 1 159 ? -22.593 -34.188 -8.118  1.00 107.16 ? 180 SER   A CB  1 
ATOM   1141 O  OG  . SER   A 1 159 ? -21.871 -33.041 -7.706  1.00 106.21 ? 180 SER   A OG  1 
ATOM   1142 N  N   . MET   A 1 160 ? -23.823 -35.487 -5.412  1.00 114.10 ? 181 MET   A N   1 
ATOM   1143 C  CA  . MET   A 1 160 ? -24.209 -35.376 -4.009  1.00 115.40 ? 181 MET   A CA  1 
ATOM   1144 C  C   . MET   A 1 160 ? -23.422 -36.349 -3.140  1.00 116.04 ? 181 MET   A C   1 
ATOM   1145 O  O   . MET   A 1 160 ? -22.971 -35.987 -2.047  1.00 116.36 ? 181 MET   A O   1 
ATOM   1146 C  CB  . MET   A 1 160 ? -25.711 -35.618 -3.859  1.00 118.73 ? 181 MET   A CB  1 
ATOM   1147 C  CG  . MET   A 1 160 ? -26.242 -35.445 -2.441  1.00 121.22 ? 181 MET   A CG  1 
ATOM   1148 S  SD  . MET   A 1 160 ? -26.939 -33.812 -2.104  1.00 127.24 ? 181 MET   A SD  1 
ATOM   1149 C  CE  . MET   A 1 160 ? -25.465 -32.825 -1.857  1.00 120.96 ? 181 MET   A CE  1 
ATOM   1150 N  N   . ASP   A 1 161 ? -23.247 -37.588 -3.608  1.00 118.77 ? 182 ASP   A N   1 
ATOM   1151 C  CA  . ASP   A 1 161 ? -22.514 -38.579 -2.826  1.00 118.14 ? 182 ASP   A CA  1 
ATOM   1152 C  C   . ASP   A 1 161 ? -21.065 -38.160 -2.621  1.00 116.35 ? 182 ASP   A C   1 
ATOM   1153 O  O   . ASP   A 1 161 ? -20.508 -38.338 -1.531  1.00 115.64 ? 182 ASP   A O   1 
ATOM   1154 C  CB  . ASP   A 1 161 ? -22.581 -39.945 -3.508  1.00 119.47 ? 182 ASP   A CB  1 
ATOM   1155 C  CG  . ASP   A 1 161 ? -23.958 -40.569 -3.428  1.00 120.41 ? 182 ASP   A CG  1 
ATOM   1156 O  OD1 . ASP   A 1 161 ? -24.933 -39.831 -3.171  1.00 122.06 ? 182 ASP   A OD1 1 
ATOM   1157 O  OD2 . ASP   A 1 161 ? -24.064 -41.800 -3.609  1.00 121.59 ? 182 ASP   A OD2 1 
ATOM   1158 N  N   . VAL   A 1 162 ? -20.434 -37.612 -3.660  1.00 114.54 ? 183 VAL   A N   1 
ATOM   1159 C  CA  . VAL   A 1 162 ? -19.051 -37.164 -3.536  1.00 113.80 ? 183 VAL   A CA  1 
ATOM   1160 C  C   . VAL   A 1 162 ? -18.959 -35.977 -2.585  1.00 113.63 ? 183 VAL   A C   1 
ATOM   1161 O  O   . VAL   A 1 162 ? -18.109 -35.946 -1.688  1.00 113.15 ? 183 VAL   A O   1 
ATOM   1162 C  CB  . VAL   A 1 162 ? -18.471 -36.824 -4.920  1.00 110.74 ? 183 VAL   A CB  1 
ATOM   1163 C  CG1 . VAL   A 1 162 ? -17.098 -36.187 -4.777  1.00 107.01 ? 183 VAL   A CG1 1 
ATOM   1164 C  CG2 . VAL   A 1 162 ? -18.394 -38.076 -5.774  1.00 111.27 ? 183 VAL   A CG2 1 
ATOM   1165 N  N   . ILE   A 1 163 ? -19.838 -34.988 -2.761  1.00 112.58 ? 184 ILE   A N   1 
ATOM   1166 C  CA  . ILE   A 1 163 ? -19.767 -33.777 -1.948  1.00 111.44 ? 184 ILE   A CA  1 
ATOM   1167 C  C   . ILE   A 1 163 ? -20.016 -34.095 -0.480  1.00 113.59 ? 184 ILE   A C   1 
ATOM   1168 O  O   . ILE   A 1 163 ? -19.293 -33.619 0.404   1.00 113.11 ? 184 ILE   A O   1 
ATOM   1169 C  CB  . ILE   A 1 163 ? -20.754 -32.720 -2.478  1.00 107.94 ? 184 ILE   A CB  1 
ATOM   1170 C  CG1 . ILE   A 1 163 ? -20.177 -32.033 -3.718  1.00 107.84 ? 184 ILE   A CG1 1 
ATOM   1171 C  CG2 . ILE   A 1 163 ? -21.084 -31.707 -1.397  1.00 105.05 ? 184 ILE   A CG2 1 
ATOM   1172 C  CD1 . ILE   A 1 163 ? -18.835 -31.368 -3.477  1.00 103.32 ? 184 ILE   A CD1 1 
ATOM   1173 N  N   . THR   A 1 164 ? -21.033 -34.910 -0.195  1.00 114.34 ? 185 THR   A N   1 
ATOM   1174 C  CA  . THR   A 1 164 ? -21.357 -35.225 1.194   1.00 113.89 ? 185 THR   A CA  1 
ATOM   1175 C  C   . THR   A 1 164 ? -20.208 -35.952 1.881   1.00 115.44 ? 185 THR   A C   1 
ATOM   1176 O  O   . THR   A 1 164 ? -19.864 -35.642 3.028   1.00 116.26 ? 185 THR   A O   1 
ATOM   1177 C  CB  . THR   A 1 164 ? -22.632 -36.064 1.262   1.00 113.89 ? 185 THR   A CB  1 
ATOM   1178 O  OG1 . THR   A 1 164 ? -22.552 -37.134 0.311   1.00 118.02 ? 185 THR   A OG1 1 
ATOM   1179 C  CG2 . THR   A 1 164 ? -23.849 -35.207 0.960   1.00 115.33 ? 185 THR   A CG2 1 
ATOM   1180 N  N   . SER   A 1 165 ? -19.600 -36.922 1.197   1.00 116.45 ? 186 SER   A N   1 
ATOM   1181 C  CA  . SER   A 1 165 ? -18.523 -37.687 1.815   1.00 117.37 ? 186 SER   A CA  1 
ATOM   1182 C  C   . SER   A 1 165 ? -17.231 -36.880 1.885   1.00 116.44 ? 186 SER   A C   1 
ATOM   1183 O  O   . SER   A 1 165 ? -16.497 -36.962 2.876   1.00 116.06 ? 186 SER   A O   1 
ATOM   1184 C  CB  . SER   A 1 165 ? -18.305 -38.994 1.052   1.00 118.31 ? 186 SER   A CB  1 
ATOM   1185 O  OG  . SER   A 1 165 ? -17.991 -38.742 -0.306  1.00 116.33 ? 186 SER   A OG  1 
ATOM   1186 N  N   . THR   A 1 166 ? -16.931 -36.100 0.842   1.00 116.00 ? 187 THR   A N   1 
ATOM   1187 C  CA  . THR   A 1 166 ? -15.695 -35.321 0.845   1.00 113.29 ? 187 THR   A CA  1 
ATOM   1188 C  C   . THR   A 1 166 ? -15.762 -34.151 1.816   1.00 114.05 ? 187 THR   A C   1 
ATOM   1189 O  O   . THR   A 1 166 ? -14.729 -33.741 2.358   1.00 112.49 ? 187 THR   A O   1 
ATOM   1190 C  CB  . THR   A 1 166 ? -15.378 -34.814 -0.561  1.00 109.35 ? 187 THR   A CB  1 
ATOM   1191 O  OG1 . THR   A 1 166 ? -16.549 -34.214 -1.132  1.00 108.99 ? 187 THR   A OG1 1 
ATOM   1192 C  CG2 . THR   A 1 166 ? -14.908 -35.957 -1.446  1.00 111.83 ? 187 THR   A CG2 1 
ATOM   1193 N  N   . SER   A 1 167 ? -16.952 -33.595 2.043   1.00 113.40 ? 188 SER   A N   1 
ATOM   1194 C  CA  . SER   A 1 167 ? -17.089 -32.442 2.927   1.00 112.21 ? 188 SER   A CA  1 
ATOM   1195 C  C   . SER   A 1 167 ? -17.219 -32.862 4.389   1.00 114.60 ? 188 SER   A C   1 
ATOM   1196 O  O   . SER   A 1 167 ? -16.402 -32.469 5.228   1.00 115.32 ? 188 SER   A O   1 
ATOM   1197 C  CB  . SER   A 1 167 ? -18.290 -31.587 2.506   1.00 111.44 ? 188 SER   A CB  1 
ATOM   1198 N  N   . PHE   A 1 168 ? -18.236 -33.666 4.706   1.00 114.22 ? 189 PHE   A N   1 
ATOM   1199 C  CA  . PHE   A 1 168 ? -18.549 -34.011 6.085   1.00 116.28 ? 189 PHE   A CA  1 
ATOM   1200 C  C   . PHE   A 1 168 ? -18.378 -35.488 6.414   1.00 117.79 ? 189 PHE   A C   1 
ATOM   1201 O  O   . PHE   A 1 168 ? -18.535 -35.860 7.582   1.00 116.39 ? 189 PHE   A O   1 
ATOM   1202 C  CB  . PHE   A 1 168 ? -19.988 -33.590 6.422   1.00 114.71 ? 189 PHE   A CB  1 
ATOM   1203 C  CG  . PHE   A 1 168 ? -20.294 -32.154 6.088   1.00 115.53 ? 189 PHE   A CG  1 
ATOM   1204 C  CD1 . PHE   A 1 168 ? -19.338 -31.167 6.268   1.00 114.75 ? 189 PHE   A CD1 1 
ATOM   1205 C  CD2 . PHE   A 1 168 ? -21.533 -31.793 5.587   1.00 115.01 ? 189 PHE   A CD2 1 
ATOM   1206 C  CE1 . PHE   A 1 168 ? -19.615 -29.849 5.958   1.00 112.86 ? 189 PHE   A CE1 1 
ATOM   1207 C  CE2 . PHE   A 1 168 ? -21.815 -30.477 5.277   1.00 113.95 ? 189 PHE   A CE2 1 
ATOM   1208 C  CZ  . PHE   A 1 168 ? -20.855 -29.504 5.462   1.00 111.66 ? 189 PHE   A CZ  1 
ATOM   1209 N  N   . GLY   A 1 169 ? -18.057 -36.334 5.438   1.00 118.11 ? 190 GLY   A N   1 
ATOM   1210 C  CA  . GLY   A 1 169 ? -17.952 -37.757 5.676   1.00 116.55 ? 190 GLY   A CA  1 
ATOM   1211 C  C   . GLY   A 1 169 ? -19.261 -38.512 5.637   1.00 117.34 ? 190 GLY   A C   1 
ATOM   1212 O  O   . GLY   A 1 169 ? -19.259 -39.730 5.859   1.00 118.27 ? 190 GLY   A O   1 
ATOM   1213 N  N   . VAL   A 1 170 ? -20.376 -37.835 5.364   1.00 117.34 ? 191 VAL   A N   1 
ATOM   1214 C  CA  . VAL   A 1 170 ? -21.669 -38.505 5.283   1.00 118.41 ? 191 VAL   A CA  1 
ATOM   1215 C  C   . VAL   A 1 170 ? -21.681 -39.435 4.079   1.00 120.04 ? 191 VAL   A C   1 
ATOM   1216 O  O   . VAL   A 1 170 ? -21.321 -39.041 2.962   1.00 120.35 ? 191 VAL   A O   1 
ATOM   1217 C  CB  . VAL   A 1 170 ? -22.805 -37.474 5.208   1.00 120.43 ? 191 VAL   A CB  1 
ATOM   1218 C  CG1 . VAL   A 1 170 ? -24.085 -38.128 4.717   1.00 124.30 ? 191 VAL   A CG1 1 
ATOM   1219 C  CG2 . VAL   A 1 170 ? -23.025 -36.836 6.571   1.00 120.59 ? 191 VAL   A CG2 1 
ATOM   1220 N  N   . ASN   A 1 171 ? -22.098 -40.679 4.302   1.00 118.89 ? 192 ASN   A N   1 
ATOM   1221 C  CA  . ASN   A 1 171 ? -22.076 -41.726 3.287   1.00 119.28 ? 192 ASN   A CA  1 
ATOM   1222 C  C   . ASN   A 1 171 ? -23.506 -42.180 3.024   1.00 120.19 ? 192 ASN   A C   1 
ATOM   1223 O  O   . ASN   A 1 171 ? -24.092 -42.899 3.839   1.00 122.04 ? 192 ASN   A O   1 
ATOM   1224 C  CB  . ASN   A 1 171 ? -21.204 -42.894 3.742   1.00 120.48 ? 192 ASN   A CB  1 
ATOM   1225 C  CG  . ASN   A 1 171 ? -19.800 -42.458 4.125   1.00 121.03 ? 192 ASN   A CG  1 
ATOM   1226 O  OD1 . ASN   A 1 171 ? -19.099 -41.820 3.340   1.00 120.74 ? 192 ASN   A OD1 1 
ATOM   1227 N  ND2 . ASN   A 1 171 ? -19.389 -42.791 5.343   1.00 119.44 ? 192 ASN   A ND2 1 
ATOM   1228 N  N   . ILE   A 1 172 ? -24.064 -41.769 1.888   1.00 121.97 ? 193 ILE   A N   1 
ATOM   1229 C  CA  . ILE   A 1 172 ? -25.442 -42.101 1.548   1.00 121.87 ? 193 ILE   A CA  1 
ATOM   1230 C  C   . ILE   A 1 172 ? -25.563 -42.225 0.036   1.00 123.80 ? 193 ILE   A C   1 
ATOM   1231 O  O   . ILE   A 1 172 ? -24.927 -41.480 -0.715  1.00 124.55 ? 193 ILE   A O   1 
ATOM   1232 C  CB  . ILE   A 1 172 ? -26.430 -41.049 2.094   1.00 118.86 ? 193 ILE   A CB  1 
ATOM   1233 N  N   . ASP   A 1 173 ? -26.384 -43.177 -0.405  1.00 124.80 ? 194 ASP   A N   1 
ATOM   1234 C  CA  . ASP   A 1 173 ? -26.763 -43.308 -1.812  1.00 126.52 ? 194 ASP   A CA  1 
ATOM   1235 C  C   . ASP   A 1 173 ? -27.970 -42.405 -2.030  1.00 128.79 ? 194 ASP   A C   1 
ATOM   1236 O  O   . ASP   A 1 173 ? -29.115 -42.795 -1.803  1.00 128.83 ? 194 ASP   A O   1 
ATOM   1237 C  CB  . ASP   A 1 173 ? -27.064 -44.761 -2.159  1.00 128.06 ? 194 ASP   A CB  1 
ATOM   1238 C  CG  . ASP   A 1 173 ? -27.441 -44.952 -3.618  1.00 131.26 ? 194 ASP   A CG  1 
ATOM   1239 O  OD1 . ASP   A 1 173 ? -27.234 -44.017 -4.420  1.00 131.39 ? 194 ASP   A OD1 1 
ATOM   1240 O  OD2 . ASP   A 1 173 ? -27.948 -46.040 -3.963  1.00 131.56 ? 194 ASP   A OD2 1 
ATOM   1241 N  N   . SER   A 1 174 ? -27.707 -41.178 -2.488  1.00 126.84 ? 195 SER   A N   1 
ATOM   1242 C  CA  A SER   A 1 174 ? -28.772 -40.189 -2.617  0.60 128.02 ? 195 SER   A CA  1 
ATOM   1243 C  CA  B SER   A 1 174 ? -28.774 -40.190 -2.615  0.40 128.51 ? 195 SER   A CA  1 
ATOM   1244 C  C   . SER   A 1 174 ? -29.810 -40.596 -3.656  1.00 130.77 ? 195 SER   A C   1 
ATOM   1245 O  O   . SER   A 1 174 ? -30.992 -40.262 -3.509  1.00 130.05 ? 195 SER   A O   1 
ATOM   1246 C  CB  A SER   A 1 174 ? -28.176 -38.826 -2.965  0.60 125.65 ? 195 SER   A CB  1 
ATOM   1247 C  CB  B SER   A 1 174 ? -28.188 -38.821 -2.963  0.40 125.42 ? 195 SER   A CB  1 
ATOM   1248 O  OG  A SER   A 1 174 ? -27.192 -38.453 -2.017  0.60 125.17 ? 195 SER   A OG  1 
ATOM   1249 O  OG  B SER   A 1 174 ? -27.633 -38.819 -4.265  0.40 123.71 ? 195 SER   A OG  1 
ATOM   1250 N  N   . LEU   A 1 175 ? -29.396 -41.304 -4.710  1.00 129.57 ? 196 LEU   A N   1 
ATOM   1251 C  CA  . LEU   A 1 175 ? -30.355 -41.721 -5.730  1.00 129.09 ? 196 LEU   A CA  1 
ATOM   1252 C  C   . LEU   A 1 175 ? -31.406 -42.656 -5.148  1.00 132.09 ? 196 LEU   A C   1 
ATOM   1253 O  O   . LEU   A 1 175 ? -32.599 -42.524 -5.445  1.00 133.39 ? 196 LEU   A O   1 
ATOM   1254 C  CB  . LEU   A 1 175 ? -29.638 -42.397 -6.897  1.00 125.35 ? 196 LEU   A CB  1 
ATOM   1255 C  CG  . LEU   A 1 175 ? -30.526 -42.650 -8.118  1.00 121.30 ? 196 LEU   A CG  1 
ATOM   1256 C  CD1 . LEU   A 1 175 ? -30.972 -41.333 -8.736  1.00 121.24 ? 196 LEU   A CD1 1 
ATOM   1257 C  CD2 . LEU   A 1 175 ? -29.817 -43.509 -9.144  1.00 120.88 ? 196 LEU   A CD2 1 
ATOM   1258 N  N   . ASN   A 1 176 ? -30.984 -43.605 -4.315  1.00 132.48 ? 197 ASN   A N   1 
ATOM   1259 C  CA  . ASN   A 1 176 ? -31.890 -44.580 -3.727  1.00 132.68 ? 197 ASN   A CA  1 
ATOM   1260 C  C   . ASN   A 1 176 ? -32.240 -44.276 -2.276  1.00 136.07 ? 197 ASN   A C   1 
ATOM   1261 O  O   . ASN   A 1 176 ? -32.948 -45.069 -1.648  1.00 138.79 ? 197 ASN   A O   1 
ATOM   1262 C  CB  . ASN   A 1 176 ? -31.290 -45.984 -3.834  1.00 130.65 ? 197 ASN   A CB  1 
ATOM   1263 C  CG  . ASN   A 1 176 ? -31.080 -46.414 -5.272  1.00 132.58 ? 197 ASN   A CG  1 
ATOM   1264 O  OD1 . ASN   A 1 176 ? -32.000 -46.902 -5.927  1.00 131.86 ? 197 ASN   A OD1 1 
ATOM   1265 N  ND2 . ASN   A 1 176 ? -29.864 -46.228 -5.772  1.00 131.84 ? 197 ASN   A ND2 1 
ATOM   1266 N  N   . ASN   A 1 177 ? -31.765 -43.159 -1.728  1.00 135.07 ? 198 ASN   A N   1 
ATOM   1267 C  CA  . ASN   A 1 177 ? -32.168 -42.690 -0.401  1.00 133.93 ? 198 ASN   A CA  1 
ATOM   1268 C  C   . ASN   A 1 177 ? -32.518 -41.208 -0.472  1.00 134.80 ? 198 ASN   A C   1 
ATOM   1269 O  O   . ASN   A 1 177 ? -31.836 -40.367 0.126   1.00 133.25 ? 198 ASN   A O   1 
ATOM   1270 C  CB  . ASN   A 1 177 ? -31.069 -42.937 0.633   1.00 132.30 ? 198 ASN   A CB  1 
ATOM   1271 C  CG  . ASN   A 1 177 ? -30.747 -44.408 0.806   1.00 131.52 ? 198 ASN   A CG  1 
ATOM   1272 O  OD1 . ASN   A 1 177 ? -29.886 -44.953 0.114   1.00 131.63 ? 198 ASN   A OD1 1 
ATOM   1273 N  ND2 . ASN   A 1 177 ? -31.433 -45.057 1.739   1.00 131.65 ? 198 ASN   A ND2 1 
ATOM   1274 N  N   . PRO   A 1 178 ? -33.586 -40.851 -1.190  1.00 136.16 ? 199 PRO   A N   1 
ATOM   1275 C  CA  . PRO   A 1 178 ? -33.986 -39.442 -1.266  1.00 136.37 ? 199 PRO   A CA  1 
ATOM   1276 C  C   . PRO   A 1 178 ? -34.784 -38.962 -0.065  1.00 138.09 ? 199 PRO   A C   1 
ATOM   1277 O  O   . PRO   A 1 178 ? -35.130 -37.777 -0.009  1.00 138.80 ? 199 PRO   A O   1 
ATOM   1278 C  CB  . PRO   A 1 178 ? -34.836 -39.405 -2.542  1.00 134.60 ? 199 PRO   A CB  1 
ATOM   1279 C  CG  . PRO   A 1 178 ? -35.473 -40.748 -2.580  1.00 133.28 ? 199 PRO   A CG  1 
ATOM   1280 C  CD  . PRO   A 1 178 ? -34.501 -41.720 -1.954  1.00 132.98 ? 199 PRO   A CD  1 
ATOM   1281 N  N   . GLN   A 1 179 ? -35.087 -39.844 0.886   1.00 137.63 ? 200 GLN   A N   1 
ATOM   1282 C  CA  . GLN   A 1 179 ? -35.868 -39.500 2.066   1.00 136.90 ? 200 GLN   A CA  1 
ATOM   1283 C  C   . GLN   A 1 179 ? -35.008 -39.225 3.292   1.00 137.53 ? 200 GLN   A C   1 
ATOM   1284 O  O   . GLN   A 1 179 ? -35.553 -38.903 4.352   1.00 137.39 ? 200 GLN   A O   1 
ATOM   1285 C  CB  . GLN   A 1 179 ? -36.862 -40.621 2.381   1.00 133.50 ? 200 GLN   A CB  1 
ATOM   1286 N  N   . ASP   A 1 180 ? -33.691 -39.347 3.178   1.00 137.61 ? 201 ASP   A N   1 
ATOM   1287 C  CA  . ASP   A 1 180 ? -32.824 -39.093 4.318   1.00 137.73 ? 201 ASP   A CA  1 
ATOM   1288 C  C   . ASP   A 1 180 ? -32.856 -37.607 4.673   1.00 139.94 ? 201 ASP   A C   1 
ATOM   1289 O  O   . ASP   A 1 180 ? -32.920 -36.757 3.778   1.00 140.11 ? 201 ASP   A O   1 
ATOM   1290 C  CB  . ASP   A 1 180 ? -31.394 -39.543 4.009   1.00 136.72 ? 201 ASP   A CB  1 
ATOM   1291 C  CG  . ASP   A 1 180 ? -30.471 -39.441 5.210   1.00 138.59 ? 201 ASP   A CG  1 
ATOM   1292 O  OD1 . ASP   A 1 180 ? -30.059 -38.313 5.556   1.00 141.96 ? 201 ASP   A OD1 1 
ATOM   1293 O  OD2 . ASP   A 1 180 ? -30.168 -40.490 5.817   1.00 134.34 ? 201 ASP   A OD2 1 
ATOM   1294 N  N   . PRO   A 1 181 ? -32.828 -37.262 5.964   1.00 140.43 ? 202 PRO   A N   1 
ATOM   1295 C  CA  . PRO   A 1 181 ? -32.886 -35.839 6.341   1.00 138.92 ? 202 PRO   A CA  1 
ATOM   1296 C  C   . PRO   A 1 181 ? -31.739 -35.008 5.793   1.00 137.23 ? 202 PRO   A C   1 
ATOM   1297 O  O   . PRO   A 1 181 ? -31.913 -33.801 5.581   1.00 137.14 ? 202 PRO   A O   1 
ATOM   1298 C  CB  . PRO   A 1 181 ? -32.869 -35.884 7.877   1.00 140.61 ? 202 PRO   A CB  1 
ATOM   1299 C  CG  . PRO   A 1 181 ? -32.325 -37.239 8.224   1.00 139.75 ? 202 PRO   A CG  1 
ATOM   1300 C  CD  . PRO   A 1 181 ? -32.831 -38.142 7.145   1.00 139.66 ? 202 PRO   A CD  1 
ATOM   1301 N  N   . PHE   A 1 182 ? -30.570 -35.607 5.558   1.00 135.46 ? 203 PHE   A N   1 
ATOM   1302 C  CA  . PHE   A 1 182 ? -29.436 -34.832 5.065   1.00 132.96 ? 203 PHE   A CA  1 
ATOM   1303 C  C   . PHE   A 1 182 ? -29.582 -34.512 3.581   1.00 132.22 ? 203 PHE   A C   1 
ATOM   1304 O  O   . PHE   A 1 182 ? -29.418 -33.358 3.169   1.00 131.61 ? 203 PHE   A O   1 
ATOM   1305 C  CB  . PHE   A 1 182 ? -28.129 -35.584 5.321   1.00 131.72 ? 203 PHE   A CB  1 
ATOM   1306 C  CG  . PHE   A 1 182 ? -26.935 -34.684 5.476   1.00 131.53 ? 203 PHE   A CG  1 
ATOM   1307 C  CD1 . PHE   A 1 182 ? -26.366 -34.063 4.375   1.00 128.82 ? 203 PHE   A CD1 1 
ATOM   1308 C  CD2 . PHE   A 1 182 ? -26.382 -34.457 6.726   1.00 129.98 ? 203 PHE   A CD2 1 
ATOM   1309 C  CE1 . PHE   A 1 182 ? -25.270 -33.232 4.520   1.00 127.06 ? 203 PHE   A CE1 1 
ATOM   1310 C  CE2 . PHE   A 1 182 ? -25.285 -33.629 6.877   1.00 128.28 ? 203 PHE   A CE2 1 
ATOM   1311 C  CZ  . PHE   A 1 182 ? -24.729 -33.016 5.773   1.00 127.55 ? 203 PHE   A CZ  1 
ATOM   1312 N  N   . VAL   A 1 183 ? -29.891 -35.523 2.765   1.00 132.63 ? 204 VAL   A N   1 
ATOM   1313 C  CA  . VAL   A 1 183 ? -30.036 -35.309 1.328   1.00 131.23 ? 204 VAL   A CA  1 
ATOM   1314 C  C   . VAL   A 1 183 ? -31.221 -34.398 1.033   1.00 131.47 ? 204 VAL   A C   1 
ATOM   1315 O  O   . VAL   A 1 183 ? -31.212 -33.653 0.045   1.00 131.35 ? 204 VAL   A O   1 
ATOM   1316 C  CB  . VAL   A 1 183 ? -30.163 -36.664 0.602   1.00 131.23 ? 204 VAL   A CB  1 
ATOM   1317 C  CG1 . VAL   A 1 183 ? -30.292 -36.466 -0.902  1.00 128.47 ? 204 VAL   A CG1 1 
ATOM   1318 C  CG2 . VAL   A 1 183 ? -28.968 -37.550 0.923   1.00 130.91 ? 204 VAL   A CG2 1 
ATOM   1319 N  N   . GLU   A 1 184 ? -32.251 -34.432 1.883   1.00 133.95 ? 205 GLU   A N   1 
ATOM   1320 C  CA  . GLU   A 1 184 ? -33.439 -33.617 1.645   1.00 135.16 ? 205 GLU   A CA  1 
ATOM   1321 C  C   . GLU   A 1 184 ? -33.109 -32.129 1.679   1.00 132.41 ? 205 GLU   A C   1 
ATOM   1322 O  O   . GLU   A 1 184 ? -33.456 -31.385 0.756   1.00 129.74 ? 205 GLU   A O   1 
ATOM   1323 C  CB  . GLU   A 1 184 ? -34.519 -33.954 2.675   1.00 134.93 ? 205 GLU   A CB  1 
ATOM   1324 N  N   . ASN   A 1 185 ? -32.432 -31.677 2.740   1.00 132.16 ? 206 ASN   A N   1 
ATOM   1325 C  CA  . ASN   A 1 185 ? -32.098 -30.259 2.852   1.00 132.58 ? 206 ASN   A CA  1 
ATOM   1326 C  C   . ASN   A 1 185 ? -31.106 -29.830 1.778   1.00 133.08 ? 206 ASN   A C   1 
ATOM   1327 O  O   . ASN   A 1 185 ? -31.266 -28.764 1.172   1.00 133.56 ? 206 ASN   A O   1 
ATOM   1328 C  CB  . ASN   A 1 185 ? -31.539 -29.956 4.241   1.00 130.55 ? 206 ASN   A CB  1 
ATOM   1329 C  CG  . ASN   A 1 185 ? -32.614 -29.912 5.308   1.00 132.81 ? 206 ASN   A CG  1 
ATOM   1330 O  OD1 . ASN   A 1 185 ? -33.178 -28.856 5.594   1.00 133.28 ? 206 ASN   A OD1 1 
ATOM   1331 N  ND2 . ASN   A 1 185 ? -32.902 -31.063 5.904   1.00 132.66 ? 206 ASN   A ND2 1 
ATOM   1332 N  N   . THR   A 1 186 ? -30.075 -30.642 1.533   1.00 132.29 ? 207 THR   A N   1 
ATOM   1333 C  CA  . THR   A 1 186 ? -29.065 -30.277 0.543   1.00 130.64 ? 207 THR   A CA  1 
ATOM   1334 C  C   . THR   A 1 186 ? -29.677 -30.142 -0.844  1.00 131.66 ? 207 THR   A C   1 
ATOM   1335 O  O   . THR   A 1 186 ? -29.376 -29.190 -1.575  1.00 132.10 ? 207 THR   A O   1 
ATOM   1336 C  CB  . THR   A 1 186 ? -27.939 -31.311 0.532   1.00 129.91 ? 207 THR   A CB  1 
ATOM   1337 O  OG1 . THR   A 1 186 ? -28.479 -32.607 0.246   1.00 133.97 ? 207 THR   A OG1 1 
ATOM   1338 C  CG2 . THR   A 1 186 ? -27.233 -31.346 1.881   1.00 129.58 ? 207 THR   A CG2 1 
ATOM   1339 N  N   . LYS   A 1 187 ? -30.543 -31.084 -1.225  1.00 132.42 ? 208 LYS   A N   1 
ATOM   1340 C  CA  . LYS   A 1 187 ? -31.247 -30.967 -2.497  1.00 132.04 ? 208 LYS   A CA  1 
ATOM   1341 C  C   . LYS   A 1 187 ? -32.224 -29.798 -2.479  1.00 132.94 ? 208 LYS   A C   1 
ATOM   1342 O  O   . LYS   A 1 187 ? -32.426 -29.135 -3.503  1.00 131.96 ? 208 LYS   A O   1 
ATOM   1343 C  CB  . LYS   A 1 187 ? -31.973 -32.272 -2.821  1.00 128.11 ? 208 LYS   A CB  1 
ATOM   1344 N  N   . LYS   A 1 188 ? -32.840 -29.533 -1.324  1.00 133.93 ? 209 LYS   A N   1 
ATOM   1345 C  CA  . LYS   A 1 188 ? -33.792 -28.435 -1.192  1.00 133.86 ? 209 LYS   A CA  1 
ATOM   1346 C  C   . LYS   A 1 188 ? -33.112 -27.097 -1.449  1.00 132.82 ? 209 LYS   A C   1 
ATOM   1347 O  O   . LYS   A 1 188 ? -32.260 -26.664 -0.666  1.00 130.15 ? 209 LYS   A O   1 
ATOM   1348 C  CB  . LYS   A 1 188 ? -34.437 -28.441 0.196   1.00 133.79 ? 209 LYS   A CB  1 
ATOM   1349 N  N   . LEU   A 1 189 ? -33.487 -26.439 -2.544  1.00 134.42 ? 210 LEU   A N   1 
ATOM   1350 C  CA  . LEU   A 1 189 ? -32.857 -25.197 -2.966  1.00 133.69 ? 210 LEU   A CA  1 
ATOM   1351 C  C   . LEU   A 1 189 ? -33.676 -24.611 -4.106  1.00 133.75 ? 210 LEU   A C   1 
ATOM   1352 O  O   . LEU   A 1 189 ? -34.199 -25.356 -4.938  1.00 134.08 ? 210 LEU   A O   1 
ATOM   1353 C  CB  . LEU   A 1 189 ? -31.409 -25.446 -3.414  1.00 131.42 ? 210 LEU   A CB  1 
ATOM   1354 C  CG  . LEU   A 1 189 ? -30.322 -24.439 -3.041  1.00 127.86 ? 210 LEU   A CG  1 
ATOM   1355 C  CD1 . LEU   A 1 189 ? -30.333 -24.173 -1.548  1.00 128.23 ? 210 LEU   A CD1 1 
ATOM   1356 C  CD2 . LEU   A 1 189 ? -28.964 -24.967 -3.475  1.00 125.97 ? 210 LEU   A CD2 1 
ATOM   1357 N  N   . LEU   A 1 190 ? -33.791 -23.285 -4.136  1.00 134.49 ? 211 LEU   A N   1 
ATOM   1358 C  CA  . LEU   A 1 190 ? -34.480 -22.603 -5.229  1.00 134.89 ? 211 LEU   A CA  1 
ATOM   1359 C  C   . LEU   A 1 190 ? -33.528 -22.502 -6.416  1.00 134.70 ? 211 LEU   A C   1 
ATOM   1360 O  O   . LEU   A 1 190 ? -32.542 -21.760 -6.371  1.00 132.96 ? 211 LEU   A O   1 
ATOM   1361 C  CB  . LEU   A 1 190 ? -34.964 -21.223 -4.790  1.00 132.23 ? 211 LEU   A CB  1 
ATOM   1362 C  CG  . LEU   A 1 190 ? -36.339 -21.099 -4.123  1.00 127.62 ? 211 LEU   A CG  1 
ATOM   1363 C  CD1 . LEU   A 1 190 ? -37.428 -21.709 -4.998  1.00 129.24 ? 211 LEU   A CD1 1 
ATOM   1364 C  CD2 . LEU   A 1 190 ? -36.350 -21.715 -2.730  1.00 126.57 ? 211 LEU   A CD2 1 
ATOM   1365 N  N   . ARG   A 1 191 ? -33.823 -23.247 -7.484  1.00 134.16 ? 212 ARG   A N   1 
ATOM   1366 C  CA  . ARG   A 1 191 ? -32.966 -23.320 -8.661  1.00 130.77 ? 212 ARG   A CA  1 
ATOM   1367 C  C   . ARG   A 1 191 ? -33.477 -22.458 -9.811  1.00 129.91 ? 212 ARG   A C   1 
ATOM   1368 O  O   . ARG   A 1 191 ? -33.178 -22.737 -10.977 1.00 129.79 ? 212 ARG   A O   1 
ATOM   1369 C  CB  . ARG   A 1 191 ? -32.815 -24.772 -9.120  1.00 128.59 ? 212 ARG   A CB  1 
ATOM   1370 C  CG  . ARG   A 1 191 ? -31.606 -25.502 -8.549  1.00 126.47 ? 212 ARG   A CG  1 
ATOM   1371 C  CD  . ARG   A 1 191 ? -31.663 -25.588 -7.034  1.00 129.28 ? 212 ARG   A CD  1 
ATOM   1372 N  NE  . ARG   A 1 191 ? -30.610 -26.438 -6.493  1.00 127.07 ? 212 ARG   A NE  1 
ATOM   1373 C  CZ  . ARG   A 1 191 ? -30.782 -27.699 -6.121  1.00 127.72 ? 212 ARG   A CZ  1 
ATOM   1374 N  NH1 . ARG   A 1 191 ? -31.960 -28.293 -6.213  1.00 127.01 ? 212 ARG   A NH1 1 
ATOM   1375 N  NH2 . ARG   A 1 191 ? -29.746 -28.380 -5.640  1.00 127.89 ? 212 ARG   A NH2 1 
ATOM   1376 N  N   . PHE   A 1 192 ? -34.241 -21.416 -9.508  1.00 126.96 ? 213 PHE   A N   1 
ATOM   1377 C  CA  . PHE   A 1 192 ? -34.803 -20.564 -10.547 1.00 124.68 ? 213 PHE   A CA  1 
ATOM   1378 C  C   . PHE   A 1 192 ? -33.815 -19.478 -10.966 1.00 122.48 ? 213 PHE   A C   1 
ATOM   1379 O  O   . PHE   A 1 192 ? -32.973 -19.049 -10.176 1.00 120.45 ? 213 PHE   A O   1 
ATOM   1380 C  CB  . PHE   A 1 192 ? -36.111 -19.937 -10.068 1.00 121.88 ? 213 PHE   A CB  1 
ATOM   1381 N  N   . PHE   A 1 194 ? -30.249 -16.758 -12.881 1.00 109.93 ? 215 PHE   A N   1 
ATOM   1382 C  CA  . PHE   A 1 194 ? -29.879 -15.358 -12.706 1.00 110.75 ? 215 PHE   A CA  1 
ATOM   1383 C  C   . PHE   A 1 194 ? -30.826 -14.438 -13.472 1.00 112.80 ? 215 PHE   A C   1 
ATOM   1384 O  O   . PHE   A 1 194 ? -30.836 -13.226 -13.258 1.00 112.30 ? 215 PHE   A O   1 
ATOM   1385 C  CB  . PHE   A 1 194 ? -28.435 -15.125 -13.155 1.00 109.17 ? 215 PHE   A CB  1 
ATOM   1386 N  N   . LEU   A 1 195 ? -31.611 -15.016 -14.379 1.00 113.71 ? 216 LEU   A N   1 
ATOM   1387 C  CA  . LEU   A 1 195 ? -32.656 -14.288 -15.085 1.00 112.56 ? 216 LEU   A CA  1 
ATOM   1388 C  C   . LEU   A 1 195 ? -34.042 -14.591 -14.530 1.00 117.45 ? 216 LEU   A C   1 
ATOM   1389 O  O   . LEU   A 1 195 ? -35.045 -14.223 -15.151 1.00 119.06 ? 216 LEU   A O   1 
ATOM   1390 C  CB  . LEU   A 1 195 ? -32.600 -14.594 -16.583 1.00 111.86 ? 216 LEU   A CB  1 
ATOM   1391 C  CG  . LEU   A 1 195 ? -31.379 -14.042 -17.328 1.00 110.12 ? 216 LEU   A CG  1 
ATOM   1392 C  CD1 . LEU   A 1 195 ? -31.448 -14.361 -18.816 1.00 104.38 ? 216 LEU   A CD1 1 
ATOM   1393 C  CD2 . LEU   A 1 195 ? -31.240 -12.541 -17.107 1.00 108.31 ? 216 LEU   A CD2 1 
ATOM   1394 N  N   . ASP   A 1 196 ? -34.114 -15.259 -13.381 1.00 118.99 ? 217 ASP   A N   1 
ATOM   1395 C  CA  . ASP   A 1 196 ? -35.377 -15.469 -12.695 1.00 120.07 ? 217 ASP   A CA  1 
ATOM   1396 C  C   . ASP   A 1 196 ? -35.940 -14.125 -12.232 1.00 120.09 ? 217 ASP   A C   1 
ATOM   1397 O  O   . ASP   A 1 196 ? -35.180 -13.182 -11.988 1.00 119.52 ? 217 ASP   A O   1 
ATOM   1398 C  CB  . ASP   A 1 196 ? -35.163 -16.410 -11.506 1.00 119.35 ? 217 ASP   A CB  1 
ATOM   1399 C  CG  . ASP   A 1 196 ? -36.361 -16.483 -10.583 1.00 120.01 ? 217 ASP   A CG  1 
ATOM   1400 O  OD1 . ASP   A 1 196 ? -37.323 -17.213 -10.902 1.00 119.56 ? 217 ASP   A OD1 1 
ATOM   1401 O  OD2 . ASP   A 1 196 ? -36.340 -15.805 -9.535  1.00 120.02 ? 217 ASP   A OD2 1 
ATOM   1402 N  N   . PRO   A 1 197 ? -37.280 -13.996 -12.136 1.00 120.76 ? 218 PRO   A N   1 
ATOM   1403 C  CA  . PRO   A 1 197 ? -37.884 -12.743 -11.655 1.00 120.04 ? 218 PRO   A CA  1 
ATOM   1404 C  C   . PRO   A 1 197 ? -37.214 -12.113 -10.440 1.00 117.84 ? 218 PRO   A C   1 
ATOM   1405 O  O   . PRO   A 1 197 ? -37.236 -10.887 -10.296 1.00 119.57 ? 218 PRO   A O   1 
ATOM   1406 C  CB  . PRO   A 1 197 ? -39.319 -13.170 -11.331 1.00 122.10 ? 218 PRO   A CB  1 
ATOM   1407 C  CG  . PRO   A 1 197 ? -39.615 -14.213 -12.357 1.00 119.10 ? 218 PRO   A CG  1 
ATOM   1408 C  CD  . PRO   A 1 197 ? -38.304 -14.909 -12.679 1.00 120.98 ? 218 PRO   A CD  1 
ATOM   1409 N  N   . PHE   A 1 198 ? -36.618 -12.922 -9.561  1.00 117.24 ? 219 PHE   A N   1 
ATOM   1410 C  CA  . PHE   A 1 198 ? -35.937 -12.363 -8.396  1.00 116.40 ? 219 PHE   A CA  1 
ATOM   1411 C  C   . PHE   A 1 198 ? -34.644 -11.662 -8.797  1.00 113.84 ? 219 PHE   A C   1 
ATOM   1412 O  O   . PHE   A 1 198 ? -34.474 -10.460 -8.562  1.00 111.42 ? 219 PHE   A O   1 
ATOM   1413 C  CB  . PHE   A 1 198 ? -35.655 -13.458 -7.367  1.00 115.87 ? 219 PHE   A CB  1 
ATOM   1414 C  CG  . PHE   A 1 198 ? -34.782 -13.005 -6.228  1.00 116.17 ? 219 PHE   A CG  1 
ATOM   1415 C  CD1 . PHE   A 1 198 ? -35.278 -12.154 -5.255  1.00 114.36 ? 219 PHE   A CD1 1 
ATOM   1416 C  CD2 . PHE   A 1 198 ? -33.465 -13.428 -6.132  1.00 116.26 ? 219 PHE   A CD2 1 
ATOM   1417 C  CE1 . PHE   A 1 198 ? -34.482 -11.732 -4.207  1.00 114.94 ? 219 PHE   A CE1 1 
ATOM   1418 C  CE2 . PHE   A 1 198 ? -32.662 -13.009 -5.084  1.00 116.01 ? 219 PHE   A CE2 1 
ATOM   1419 C  CZ  . PHE   A 1 198 ? -33.172 -12.160 -4.120  1.00 113.50 ? 219 PHE   A CZ  1 
ATOM   1420 N  N   . PHE   A 1 199 ? -33.713 -12.405 -9.402  1.00 113.27 ? 220 PHE   A N   1 
ATOM   1421 C  CA  . PHE   A 1 199 ? -32.408 -11.839 -9.724  1.00 113.78 ? 220 PHE   A CA  1 
ATOM   1422 C  C   . PHE   A 1 199 ? -32.508 -10.754 -10.788 1.00 112.06 ? 220 PHE   A C   1 
ATOM   1423 O  O   . PHE   A 1 199 ? -31.672 -9.843  -10.820 1.00 110.17 ? 220 PHE   A O   1 
ATOM   1424 C  CB  . PHE   A 1 199 ? -31.455 -12.944 -10.172 1.00 112.61 ? 220 PHE   A CB  1 
ATOM   1425 C  CG  . PHE   A 1 199 ? -31.340 -14.074 -9.193  1.00 114.08 ? 220 PHE   A CG  1 
ATOM   1426 C  CD1 . PHE   A 1 199 ? -30.489 -13.982 -8.104  1.00 111.26 ? 220 PHE   A CD1 1 
ATOM   1427 C  CD2 . PHE   A 1 199 ? -32.086 -15.229 -9.359  1.00 116.78 ? 220 PHE   A CD2 1 
ATOM   1428 C  CE1 . PHE   A 1 199 ? -30.382 -15.021 -7.200  1.00 110.04 ? 220 PHE   A CE1 1 
ATOM   1429 C  CE2 . PHE   A 1 199 ? -31.985 -16.273 -8.459  1.00 115.87 ? 220 PHE   A CE2 1 
ATOM   1430 C  CZ  . PHE   A 1 199 ? -31.131 -16.169 -7.378  1.00 114.43 ? 220 PHE   A CZ  1 
ATOM   1431 N  N   . LEU   A 1 200 ? -33.505 -10.837 -11.671 1.00 112.23 ? 221 LEU   A N   1 
ATOM   1432 C  CA  . LEU   A 1 200 ? -33.740 -9.743  -12.606 1.00 111.34 ? 221 LEU   A CA  1 
ATOM   1433 C  C   . LEU   A 1 200 ? -34.169 -8.482  -11.868 1.00 109.64 ? 221 LEU   A C   1 
ATOM   1434 O  O   . LEU   A 1 200 ? -33.809 -7.367  -12.265 1.00 109.80 ? 221 LEU   A O   1 
ATOM   1435 C  CB  . LEU   A 1 200 ? -34.795 -10.147 -13.640 1.00 111.62 ? 221 LEU   A CB  1 
ATOM   1436 N  N   . SER   A 1 201 ? -34.946 -8.642  -10.794 1.00 109.58 ? 222 SER   A N   1 
ATOM   1437 C  CA  . SER   A 1 201 ? -35.428 -7.491  -10.037 1.00 110.27 ? 222 SER   A CA  1 
ATOM   1438 C  C   . SER   A 1 201 ? -34.290 -6.785  -9.309  1.00 110.19 ? 222 SER   A C   1 
ATOM   1439 O  O   . SER   A 1 201 ? -34.144 -5.562  -9.409  1.00 108.63 ? 222 SER   A O   1 
ATOM   1440 C  CB  . SER   A 1 201 ? -36.509 -7.937  -9.052  1.00 110.37 ? 222 SER   A CB  1 
ATOM   1441 O  OG  . SER   A 1 201 ? -37.639 -8.445  -9.737  1.00 107.88 ? 222 SER   A OG  1 
ATOM   1442 N  N   . ILE   A 1 202 ? -33.458 -7.539  -8.584  1.00 109.17 ? 223 ILE   A N   1 
ATOM   1443 C  CA  . ILE   A 1 202 ? -32.375 -6.923  -7.824  1.00 107.12 ? 223 ILE   A CA  1 
ATOM   1444 C  C   . ILE   A 1 202 ? -31.392 -6.211  -8.741  1.00 108.03 ? 223 ILE   A C   1 
ATOM   1445 O  O   . ILE   A 1 202 ? -30.646 -5.336  -8.289  1.00 109.35 ? 223 ILE   A O   1 
ATOM   1446 C  CB  . ILE   A 1 202 ? -31.656 -7.969  -6.945  1.00 105.16 ? 223 ILE   A CB  1 
ATOM   1447 C  CG1 . ILE   A 1 202 ? -31.020 -9.058  -7.810  1.00 107.52 ? 223 ILE   A CG1 1 
ATOM   1448 C  CG2 . ILE   A 1 202 ? -32.619 -8.568  -5.927  1.00 105.57 ? 223 ILE   A CG2 1 
ATOM   1449 C  CD1 . ILE   A 1 202 ? -30.344 -10.157 -7.018  1.00 108.01 ? 223 ILE   A CD1 1 
ATOM   1450 N  N   . THR   A 1 203 ? -31.367 -6.570  -10.026 1.00 106.55 ? 224 THR   A N   1 
ATOM   1451 C  CA  . THR   A 1 203 ? -30.598 -5.802  -10.999 1.00 101.22 ? 224 THR   A CA  1 
ATOM   1452 C  C   . THR   A 1 203 ? -31.185 -4.405  -11.179 1.00 101.45 ? 224 THR   A C   1 
ATOM   1453 O  O   . THR   A 1 203 ? -30.468 -3.401  -11.087 1.00 100.72 ? 224 THR   A O   1 
ATOM   1454 C  CB  . THR   A 1 203 ? -30.562 -6.548  -12.333 1.00 99.72  ? 224 THR   A CB  1 
ATOM   1455 O  OG1 . THR   A 1 203 ? -29.731 -7.710  -12.214 1.00 97.52  ? 224 THR   A OG1 1 
ATOM   1456 C  CG2 . THR   A 1 203 ? -30.029 -5.653  -13.430 1.00 98.72  ? 224 THR   A CG2 1 
ATOM   1457 N  N   . VAL   A 1 204 ? -32.494 -4.324  -11.431 1.00 103.06 ? 225 VAL   A N   1 
ATOM   1458 C  CA  . VAL   A 1 204 ? -33.166 -3.031  -11.530 1.00 105.68 ? 225 VAL   A CA  1 
ATOM   1459 C  C   . VAL   A 1 204 ? -33.303 -2.387  -10.159 1.00 107.03 ? 225 VAL   A C   1 
ATOM   1460 O  O   . VAL   A 1 204 ? -33.242 -1.157  -10.032 1.00 108.37 ? 225 VAL   A O   1 
ATOM   1461 C  CB  . VAL   A 1 204 ? -34.535 -3.199  -12.214 1.00 107.20 ? 225 VAL   A CB  1 
ATOM   1462 C  CG1 . VAL   A 1 204 ? -35.320 -1.893  -12.200 1.00 106.83 ? 225 VAL   A CG1 1 
ATOM   1463 C  CG2 . VAL   A 1 204 ? -34.345 -3.686  -13.628 1.00 100.18 ? 225 VAL   A CG2 1 
ATOM   1464 N  N   . PHE   A 1 205 ? -33.473 -3.194  -9.114  1.00 105.40 ? 226 PHE   A N   1 
ATOM   1465 C  CA  . PHE   A 1 205 ? -33.711 -2.707  -7.757  1.00 108.60 ? 226 PHE   A CA  1 
ATOM   1466 C  C   . PHE   A 1 205 ? -32.598 -3.162  -6.813  1.00 107.95 ? 226 PHE   A C   1 
ATOM   1467 O  O   . PHE   A 1 205 ? -32.850 -3.921  -5.869  1.00 107.87 ? 226 PHE   A O   1 
ATOM   1468 C  CB  . PHE   A 1 205 ? -35.065 -3.194  -7.243  1.00 111.09 ? 226 PHE   A CB  1 
ATOM   1469 C  CG  . PHE   A 1 205 ? -36.221 -2.942  -8.181  1.00 113.59 ? 226 PHE   A CG  1 
ATOM   1470 C  CD1 . PHE   A 1 205 ? -36.520 -3.838  -9.196  1.00 113.34 ? 226 PHE   A CD1 1 
ATOM   1471 C  CD2 . PHE   A 1 205 ? -37.037 -1.836  -8.019  1.00 112.36 ? 226 PHE   A CD2 1 
ATOM   1472 C  CE1 . PHE   A 1 205 ? -37.586 -3.619  -10.047 1.00 112.04 ? 226 PHE   A CE1 1 
ATOM   1473 C  CE2 . PHE   A 1 205 ? -38.106 -1.615  -8.867  1.00 111.49 ? 226 PHE   A CE2 1 
ATOM   1474 C  CZ  . PHE   A 1 205 ? -38.379 -2.505  -9.881  1.00 111.71 ? 226 PHE   A CZ  1 
ATOM   1475 N  N   . PRO   A 1 206 ? -31.353 -2.718  -7.028  1.00 106.25 ? 227 PRO   A N   1 
ATOM   1476 C  CA  . PRO   A 1 206 ? -30.296 -3.059  -6.063  1.00 105.38 ? 227 PRO   A CA  1 
ATOM   1477 C  C   . PRO   A 1 206 ? -30.466 -2.358  -4.731  1.00 106.56 ? 227 PRO   A C   1 
ATOM   1478 O  O   . PRO   A 1 206 ? -29.925 -2.829  -3.723  1.00 105.50 ? 227 PRO   A O   1 
ATOM   1479 C  CB  . PRO   A 1 206 ? -29.015 -2.610  -6.774  1.00 102.68 ? 227 PRO   A CB  1 
ATOM   1480 C  CG  . PRO   A 1 206 ? -29.457 -1.460  -7.597  1.00 106.91 ? 227 PRO   A CG  1 
ATOM   1481 C  CD  . PRO   A 1 206 ? -30.859 -1.784  -8.057  1.00 106.95 ? 227 PRO   A CD  1 
ATOM   1482 N  N   . PHE   A 1 207 ? -31.205 -1.246  -4.700  1.00 104.10 ? 228 PHE   A N   1 
ATOM   1483 C  CA  . PHE   A 1 207 ? -31.494 -0.560  -3.448  1.00 103.79 ? 228 PHE   A CA  1 
ATOM   1484 C  C   . PHE   A 1 207 ? -32.348 -1.405  -2.515  1.00 103.99 ? 228 PHE   A C   1 
ATOM   1485 O  O   . PHE   A 1 207 ? -32.344 -1.166  -1.302  1.00 106.23 ? 228 PHE   A O   1 
ATOM   1486 C  CB  . PHE   A 1 207 ? -32.184 0.775   -3.738  1.00 105.83 ? 228 PHE   A CB  1 
ATOM   1487 C  CG  . PHE   A 1 207 ? -33.219 0.702   -4.827  1.00 107.09 ? 228 PHE   A CG  1 
ATOM   1488 C  CD1 . PHE   A 1 207 ? -34.532 0.383   -4.533  1.00 109.99 ? 228 PHE   A CD1 1 
ATOM   1489 C  CD2 . PHE   A 1 207 ? -32.878 0.960   -6.145  1.00 105.05 ? 228 PHE   A CD2 1 
ATOM   1490 C  CE1 . PHE   A 1 207 ? -35.487 0.318   -5.528  1.00 107.36 ? 228 PHE   A CE1 1 
ATOM   1491 C  CE2 . PHE   A 1 207 ? -33.828 0.894   -7.146  1.00 106.00 ? 228 PHE   A CE2 1 
ATOM   1492 C  CZ  . PHE   A 1 207 ? -35.133 0.577   -6.836  1.00 107.88 ? 228 PHE   A CZ  1 
ATOM   1493 N  N   . LEU   A 1 208 ? -33.079 -2.383  -3.048  1.00 105.07 ? 229 LEU   A N   1 
ATOM   1494 C  CA  . LEU   A 1 208 ? -33.892 -3.265  -2.223  1.00 107.54 ? 229 LEU   A CA  1 
ATOM   1495 C  C   . LEU   A 1 208 ? -33.090 -4.396  -1.589  1.00 106.11 ? 229 LEU   A C   1 
ATOM   1496 O  O   . LEU   A 1 208 ? -33.634 -5.118  -0.746  1.00 106.06 ? 229 LEU   A O   1 
ATOM   1497 C  CB  . LEU   A 1 208 ? -35.036 -3.854  -3.052  1.00 106.76 ? 229 LEU   A CB  1 
ATOM   1498 C  CG  . LEU   A 1 208 ? -35.963 -2.852  -3.744  1.00 109.40 ? 229 LEU   A CG  1 
ATOM   1499 C  CD1 . LEU   A 1 208 ? -37.097 -3.575  -4.444  1.00 111.72 ? 229 LEU   A CD1 1 
ATOM   1500 C  CD2 . LEU   A 1 208 ? -36.511 -1.842  -2.756  1.00 106.99 ? 229 LEU   A CD2 1 
ATOM   1501 N  N   . ILE   A 1 209 ? -31.827 -4.580  -1.981  1.00 104.33 ? 230 ILE   A N   1 
ATOM   1502 C  CA  . ILE   A 1 209 ? -31.007 -5.627  -1.369  1.00 106.71 ? 230 ILE   A CA  1 
ATOM   1503 C  C   . ILE   A 1 209 ? -30.784 -5.386  0.121   1.00 107.27 ? 230 ILE   A C   1 
ATOM   1504 O  O   . ILE   A 1 209 ? -31.030 -6.308  0.915   1.00 106.58 ? 230 ILE   A O   1 
ATOM   1505 C  CB  . ILE   A 1 209 ? -29.691 -5.794  -2.149  1.00 105.21 ? 230 ILE   A CB  1 
ATOM   1506 C  CG1 . ILE   A 1 209 ? -29.955 -6.411  -3.523  1.00 107.38 ? 230 ILE   A CG1 1 
ATOM   1507 C  CG2 . ILE   A 1 209 ? -28.702 -6.641  -1.360  1.00 105.17 ? 230 ILE   A CG2 1 
ATOM   1508 C  CD1 . ILE   A 1 209 ? -28.706 -6.577  -4.360  1.00 107.49 ? 230 ILE   A CD1 1 
ATOM   1509 N  N   . PRO   A 1 210 ? -30.334 -4.206  0.570   1.00 105.50 ? 231 PRO   A N   1 
ATOM   1510 C  CA  . PRO   A 1 210 ? -30.203 -3.995  2.022   1.00 105.43 ? 231 PRO   A CA  1 
ATOM   1511 C  C   . PRO   A 1 210 ? -31.529 -4.066  2.753   1.00 104.91 ? 231 PRO   A C   1 
ATOM   1512 O  O   . PRO   A 1 210 ? -31.543 -4.328  3.962   1.00 106.78 ? 231 PRO   A O   1 
ATOM   1513 C  CB  . PRO   A 1 210 ? -29.577 -2.596  2.126   1.00 105.33 ? 231 PRO   A CB  1 
ATOM   1514 C  CG  . PRO   A 1 210 ? -29.006 -2.319  0.779   1.00 103.78 ? 231 PRO   A CG  1 
ATOM   1515 C  CD  . PRO   A 1 210 ? -29.908 -3.013  -0.182  1.00 105.91 ? 231 PRO   A CD  1 
ATOM   1516 N  N   . ILE   A 1 211 ? -32.643 -3.836  2.055   1.00 106.02 ? 232 ILE   A N   1 
ATOM   1517 C  CA  . ILE   A 1 211 ? -33.961 -3.999  2.661   1.00 106.89 ? 232 ILE   A CA  1 
ATOM   1518 C  C   . ILE   A 1 211 ? -34.154 -5.435  3.126   1.00 108.83 ? 232 ILE   A C   1 
ATOM   1519 O  O   . ILE   A 1 211 ? -34.542 -5.691  4.272   1.00 110.20 ? 232 ILE   A O   1 
ATOM   1520 C  CB  . ILE   A 1 211 ? -35.057 -3.579  1.664   1.00 106.12 ? 232 ILE   A CB  1 
ATOM   1521 C  CG1 . ILE   A 1 211 ? -35.201 -2.058  1.638   1.00 107.66 ? 232 ILE   A CG1 1 
ATOM   1522 C  CG2 . ILE   A 1 211 ? -36.377 -4.267  1.977   1.00 107.53 ? 232 ILE   A CG2 1 
ATOM   1523 C  CD1 . ILE   A 1 211 ? -36.332 -1.579  0.782   1.00 111.09 ? 232 ILE   A CD1 1 
ATOM   1524 N  N   . LEU   A 1 212 ? -33.868 -6.397  2.248   1.00 106.73 ? 233 LEU   A N   1 
ATOM   1525 C  CA  . LEU   A 1 212 ? -34.082 -7.797  2.588   1.00 106.78 ? 233 LEU   A CA  1 
ATOM   1526 C  C   . LEU   A 1 212 ? -33.034 -8.324  3.558   1.00 108.97 ? 233 LEU   A C   1 
ATOM   1527 O  O   . LEU   A 1 212 ? -33.272 -9.344  4.212   1.00 110.85 ? 233 LEU   A O   1 
ATOM   1528 C  CB  . LEU   A 1 212 ? -34.104 -8.638  1.314   1.00 108.75 ? 233 LEU   A CB  1 
ATOM   1529 C  CG  . LEU   A 1 212 ? -35.044 -8.077  0.247   1.00 110.62 ? 233 LEU   A CG  1 
ATOM   1530 C  CD1 . LEU   A 1 212 ? -35.104 -8.960  -0.991  1.00 108.45 ? 233 LEU   A CD1 1 
ATOM   1531 C  CD2 . LEU   A 1 212 ? -36.423 -7.889  0.847   1.00 112.69 ? 233 LEU   A CD2 1 
ATOM   1532 N  N   . GLU   A 1 213 ? -31.883 -7.656  3.663   1.00 109.35 ? 234 GLU   A N   1 
ATOM   1533 C  CA  . GLU   A 1 213 ? -30.894 -8.049  4.661   1.00 109.13 ? 234 GLU   A CA  1 
ATOM   1534 C  C   . GLU   A 1 213 ? -31.401 -7.781  6.073   1.00 111.52 ? 234 GLU   A C   1 
ATOM   1535 O  O   . GLU   A 1 213 ? -31.250 -8.626  6.963   1.00 114.42 ? 234 GLU   A O   1 
ATOM   1536 C  CB  . GLU   A 1 213 ? -29.576 -7.315  4.413   1.00 106.17 ? 234 GLU   A CB  1 
ATOM   1537 C  CG  . GLU   A 1 213 ? -28.934 -7.589  3.056   1.00 107.93 ? 234 GLU   A CG  1 
ATOM   1538 C  CD  . GLU   A 1 213 ? -28.180 -8.909  3.002   1.00 107.08 ? 234 GLU   A CD  1 
ATOM   1539 O  OE1 . GLU   A 1 213 ? -28.479 -9.816  3.808   1.00 103.83 ? 234 GLU   A OE1 1 
ATOM   1540 O  OE2 . GLU   A 1 213 ? -27.277 -9.037  2.148   1.00 106.15 ? 234 GLU   A OE2 1 
ATOM   1541 N  N   . VAL   A 1 214 ? -32.008 -6.613  6.297   1.00 111.28 ? 235 VAL   A N   1 
ATOM   1542 C  CA  . VAL   A 1 214 ? -32.549 -6.302  7.614   1.00 113.21 ? 235 VAL   A CA  1 
ATOM   1543 C  C   . VAL   A 1 214 ? -33.816 -7.098  7.893   1.00 111.36 ? 235 VAL   A C   1 
ATOM   1544 O  O   . VAL   A 1 214 ? -34.198 -7.261  9.058   1.00 110.82 ? 235 VAL   A O   1 
ATOM   1545 C  CB  . VAL   A 1 214 ? -32.803 -4.787  7.753   1.00 111.94 ? 235 VAL   A CB  1 
ATOM   1546 C  CG1 . VAL   A 1 214 ? -34.157 -4.406  7.170   1.00 109.29 ? 235 VAL   A CG1 1 
ATOM   1547 C  CG2 . VAL   A 1 214 ? -32.692 -4.355  9.211   1.00 111.82 ? 235 VAL   A CG2 1 
ATOM   1548 N  N   . LEU   A 1 215 ? -34.478 -7.607  6.853   1.00 110.82 ? 236 LEU   A N   1 
ATOM   1549 C  CA  . LEU   A 1 215 ? -35.642 -8.465  7.029   1.00 111.16 ? 236 LEU   A CA  1 
ATOM   1550 C  C   . LEU   A 1 215 ? -35.265 -9.912  7.312   1.00 115.82 ? 236 LEU   A C   1 
ATOM   1551 O  O   . LEU   A 1 215 ? -36.163 -10.738 7.511   1.00 114.75 ? 236 LEU   A O   1 
ATOM   1552 C  CB  . LEU   A 1 215 ? -36.543 -8.409  5.790   1.00 108.06 ? 236 LEU   A CB  1 
ATOM   1553 C  CG  . LEU   A 1 215 ? -37.137 -7.066  5.358   1.00 109.39 ? 236 LEU   A CG  1 
ATOM   1554 C  CD1 . LEU   A 1 215 ? -38.318 -7.276  4.417   1.00 106.24 ? 236 LEU   A CD1 1 
ATOM   1555 C  CD2 . LEU   A 1 215 ? -37.534 -6.219  6.555   1.00 112.47 ? 236 LEU   A CD2 1 
ATOM   1556 N  N   . ASN   A 1 216 ? -33.968 -10.229 7.339   1.00 117.23 ? 237 ASN   A N   1 
ATOM   1557 C  CA  . ASN   A 1 216 ? -33.483 -11.596 7.531   1.00 117.90 ? 237 ASN   A CA  1 
ATOM   1558 C  C   . ASN   A 1 216 ? -33.992 -12.524 6.429   1.00 115.19 ? 237 ASN   A C   1 
ATOM   1559 O  O   . ASN   A 1 216 ? -34.335 -13.683 6.674   1.00 114.92 ? 237 ASN   A O   1 
ATOM   1560 C  CB  . ASN   A 1 216 ? -33.858 -12.131 8.916   1.00 117.22 ? 237 ASN   A CB  1 
ATOM   1561 N  N   . ILE   A 1 217 ? -34.044 -12.007 5.203   1.00 114.00 ? 238 ILE   A N   1 
ATOM   1562 C  CA  . ILE   A 1 217 ? -34.348 -12.802 4.018   1.00 112.92 ? 238 ILE   A CA  1 
ATOM   1563 C  C   . ILE   A 1 217 ? -33.031 -13.148 3.340   1.00 112.27 ? 238 ILE   A C   1 
ATOM   1564 O  O   . ILE   A 1 217 ? -32.201 -12.264 3.091   1.00 110.39 ? 238 ILE   A O   1 
ATOM   1565 C  CB  . ILE   A 1 217 ? -35.288 -12.052 3.056   1.00 111.35 ? 238 ILE   A CB  1 
ATOM   1566 C  CG1 . ILE   A 1 217 ? -36.754 -12.328 3.399   1.00 111.81 ? 238 ILE   A CG1 1 
ATOM   1567 C  CG2 . ILE   A 1 217 ? -35.022 -12.456 1.611   1.00 112.89 ? 238 ILE   A CG2 1 
ATOM   1568 C  CD1 . ILE   A 1 217 ? -37.204 -11.755 4.713   1.00 116.43 ? 238 ILE   A CD1 1 
ATOM   1569 N  N   . CYS   A 1 218 ? -32.830 -14.431 3.057   1.00 111.79 ? 239 CYS   A N   1 
ATOM   1570 C  CA  . CYS   A 1 218 ? -31.600 -14.917 2.450   1.00 111.57 ? 239 CYS   A CA  1 
ATOM   1571 C  C   . CYS   A 1 218 ? -31.919 -15.657 1.161   1.00 113.53 ? 239 CYS   A C   1 
ATOM   1572 O  O   . CYS   A 1 218 ? -32.947 -16.335 1.060   1.00 114.31 ? 239 CYS   A O   1 
ATOM   1573 C  CB  . CYS   A 1 218 ? -30.841 -15.839 3.408   1.00 110.73 ? 239 CYS   A CB  1 
ATOM   1574 S  SG  . CYS   A 1 218 ? -30.475 -15.092 5.011   1.00 118.69 ? 239 CYS   A SG  1 
ATOM   1575 N  N   . VAL   A 1 219 ? -31.031 -15.519 0.173   1.00 114.18 ? 240 VAL   A N   1 
ATOM   1576 C  CA  . VAL   A 1 219 ? -31.179 -16.282 -1.062  1.00 112.21 ? 240 VAL   A CA  1 
ATOM   1577 C  C   . VAL   A 1 219 ? -31.074 -17.772 -0.770  1.00 114.48 ? 240 VAL   A C   1 
ATOM   1578 O  O   . VAL   A 1 219 ? -31.735 -18.592 -1.419  1.00 116.80 ? 240 VAL   A O   1 
ATOM   1579 C  CB  . VAL   A 1 219 ? -30.146 -15.820 -2.111  1.00 108.22 ? 240 VAL   A CB  1 
ATOM   1580 C  CG1 . VAL   A 1 219 ? -28.724 -16.048 -1.614  1.00 108.68 ? 240 VAL   A CG1 1 
ATOM   1581 C  CG2 . VAL   A 1 219 ? -30.381 -16.523 -3.443  1.00 108.18 ? 240 VAL   A CG2 1 
ATOM   1582 N  N   . PHE   A 1 220 ? -30.256 -18.145 0.205   1.00 116.15 ? 241 PHE   A N   1 
ATOM   1583 C  CA  . PHE   A 1 220 ? -30.249 -19.509 0.709   1.00 117.09 ? 241 PHE   A CA  1 
ATOM   1584 C  C   . PHE   A 1 220 ? -31.481 -19.724 1.577   1.00 118.60 ? 241 PHE   A C   1 
ATOM   1585 O  O   . PHE   A 1 220 ? -31.696 -18.957 2.526   1.00 117.70 ? 241 PHE   A O   1 
ATOM   1586 C  CB  . PHE   A 1 220 ? -28.981 -19.779 1.512   1.00 114.15 ? 241 PHE   A CB  1 
ATOM   1587 C  CG  . PHE   A 1 220 ? -27.737 -19.847 0.677   1.00 112.97 ? 241 PHE   A CG  1 
ATOM   1588 C  CD1 . PHE   A 1 220 ? -27.331 -21.046 0.116   1.00 115.92 ? 241 PHE   A CD1 1 
ATOM   1589 C  CD2 . PHE   A 1 220 ? -26.972 -18.714 0.454   1.00 110.52 ? 241 PHE   A CD2 1 
ATOM   1590 C  CE1 . PHE   A 1 220 ? -26.185 -21.116 -0.655  1.00 112.58 ? 241 PHE   A CE1 1 
ATOM   1591 C  CE2 . PHE   A 1 220 ? -25.824 -18.776 -0.316  1.00 109.94 ? 241 PHE   A CE2 1 
ATOM   1592 C  CZ  . PHE   A 1 220 ? -25.430 -19.980 -0.872  1.00 110.17 ? 241 PHE   A CZ  1 
ATOM   1593 N  N   . PRO   A 1 221 ? -32.318 -20.719 1.289   1.00 121.68 ? 242 PRO   A N   1 
ATOM   1594 C  CA  . PRO   A 1 221 ? -33.480 -20.978 2.147   1.00 123.97 ? 242 PRO   A CA  1 
ATOM   1595 C  C   . PRO   A 1 221 ? -33.049 -21.235 3.583   1.00 125.28 ? 242 PRO   A C   1 
ATOM   1596 O  O   . PRO   A 1 221 ? -32.167 -22.055 3.849   1.00 125.28 ? 242 PRO   A O   1 
ATOM   1597 C  CB  . PRO   A 1 221 ? -34.127 -22.216 1.511   1.00 124.48 ? 242 PRO   A CB  1 
ATOM   1598 C  CG  . PRO   A 1 221 ? -33.071 -22.803 0.621   1.00 126.02 ? 242 PRO   A CG  1 
ATOM   1599 C  CD  . PRO   A 1 221 ? -32.259 -21.642 0.145   1.00 122.59 ? 242 PRO   A CD  1 
ATOM   1600 N  N   . ARG   A 1 222 ? -33.684 -20.517 4.512   1.00 128.03 ? 243 ARG   A N   1 
ATOM   1601 C  CA  . ARG   A 1 222 ? -33.273 -20.560 5.911   1.00 128.77 ? 243 ARG   A CA  1 
ATOM   1602 C  C   . ARG   A 1 222 ? -33.428 -21.945 6.524   1.00 129.27 ? 243 ARG   A C   1 
ATOM   1603 O  O   . ARG   A 1 222 ? -32.728 -22.260 7.493   1.00 127.45 ? 243 ARG   A O   1 
ATOM   1604 C  CB  . ARG   A 1 222 ? -34.071 -19.538 6.723   1.00 129.92 ? 243 ARG   A CB  1 
ATOM   1605 N  N   . GLU   A 1 223 ? -34.327 -22.774 5.988   1.00 130.52 ? 244 GLU   A N   1 
ATOM   1606 C  CA  . GLU   A 1 223 ? -34.489 -24.126 6.514   1.00 131.51 ? 244 GLU   A CA  1 
ATOM   1607 C  C   . GLU   A 1 223 ? -33.228 -24.956 6.304   1.00 131.26 ? 244 GLU   A C   1 
ATOM   1608 O  O   . GLU   A 1 223 ? -32.814 -25.707 7.195   1.00 130.66 ? 244 GLU   A O   1 
ATOM   1609 C  CB  . GLU   A 1 223 ? -35.692 -24.803 5.859   1.00 128.92 ? 244 GLU   A CB  1 
ATOM   1610 N  N   . VAL   A 1 224 ? -32.607 -24.837 5.130   1.00 130.52 ? 245 VAL   A N   1 
ATOM   1611 C  CA  . VAL   A 1 224 ? -31.416 -25.628 4.833   1.00 128.36 ? 245 VAL   A CA  1 
ATOM   1612 C  C   . VAL   A 1 224 ? -30.230 -25.146 5.659   1.00 126.28 ? 245 VAL   A C   1 
ATOM   1613 O  O   . VAL   A 1 224 ? -29.481 -25.951 6.226   1.00 124.75 ? 245 VAL   A O   1 
ATOM   1614 C  CB  . VAL   A 1 224 ? -31.107 -25.582 3.327   1.00 128.43 ? 245 VAL   A CB  1 
ATOM   1615 C  CG1 . VAL   A 1 224 ? -29.911 -26.463 3.008   1.00 130.73 ? 245 VAL   A CG1 1 
ATOM   1616 C  CG2 . VAL   A 1 224 ? -32.326 -26.004 2.524   1.00 129.53 ? 245 VAL   A CG2 1 
ATOM   1617 N  N   . THR   A 1 225 ? -30.036 -23.826 5.734   1.00 127.12 ? 246 THR   A N   1 
ATOM   1618 C  CA  . THR   A 1 225 ? -28.882 -23.288 6.447   1.00 124.98 ? 246 THR   A CA  1 
ATOM   1619 C  C   . THR   A 1 225 ? -28.928 -23.648 7.925   1.00 122.42 ? 246 THR   A C   1 
ATOM   1620 O  O   . THR   A 1 225 ? -27.909 -24.035 8.508   1.00 119.61 ? 246 THR   A O   1 
ATOM   1621 C  CB  . THR   A 1 225 ? -28.813 -21.770 6.273   1.00 124.73 ? 246 THR   A CB  1 
ATOM   1622 O  OG1 . THR   A 1 225 ? -29.956 -21.165 6.890   1.00 129.61 ? 246 THR   A OG1 1 
ATOM   1623 C  CG2 . THR   A 1 225 ? -28.784 -21.404 4.796   1.00 119.47 ? 246 THR   A CG2 1 
ATOM   1624 N  N   . ASN   A 1 226 ? -30.103 -23.533 8.547   1.00 124.40 ? 247 ASN   A N   1 
ATOM   1625 C  CA  . ASN   A 1 226 ? -30.223 -23.882 9.958   1.00 124.77 ? 247 ASN   A CA  1 
ATOM   1626 C  C   . ASN   A 1 226 ? -29.951 -25.363 10.182  1.00 124.16 ? 247 ASN   A C   1 
ATOM   1627 O  O   . ASN   A 1 226 ? -29.338 -25.744 11.187  1.00 120.77 ? 247 ASN   A O   1 
ATOM   1628 C  CB  . ASN   A 1 226 ? -31.606 -23.497 10.482  1.00 126.38 ? 247 ASN   A CB  1 
ATOM   1629 C  CG  . ASN   A 1 226 ? -31.848 -21.999 10.438  1.00 128.58 ? 247 ASN   A CG  1 
ATOM   1630 O  OD1 . ASN   A 1 226 ? -32.970 -21.545 10.213  1.00 132.84 ? 247 ASN   A OD1 1 
ATOM   1631 N  ND2 . ASN   A 1 226 ? -30.790 -21.223 10.644  1.00 124.59 ? 247 ASN   A ND2 1 
ATOM   1632 N  N   . PHE   A 1 227 ? -30.405 -26.217 9.261   1.00 125.43 ? 248 PHE   A N   1 
ATOM   1633 C  CA  . PHE   A 1 227 ? -30.062 -27.633 9.340   1.00 123.29 ? 248 PHE   A CA  1 
ATOM   1634 C  C   . PHE   A 1 227 ? -28.557 -27.835 9.215   1.00 123.22 ? 248 PHE   A C   1 
ATOM   1635 O  O   . PHE   A 1 227 ? -27.947 -28.547 10.019  1.00 123.44 ? 248 PHE   A O   1 
ATOM   1636 C  CB  . PHE   A 1 227 ? -30.799 -28.422 8.258   1.00 123.57 ? 248 PHE   A CB  1 
ATOM   1637 C  CG  . PHE   A 1 227 ? -30.300 -29.833 8.095   1.00 127.39 ? 248 PHE   A CG  1 
ATOM   1638 C  CD1 . PHE   A 1 227 ? -30.606 -30.804 9.034   1.00 129.18 ? 248 PHE   A CD1 1 
ATOM   1639 C  CD2 . PHE   A 1 227 ? -29.521 -30.185 7.006   1.00 127.05 ? 248 PHE   A CD2 1 
ATOM   1640 C  CE1 . PHE   A 1 227 ? -30.145 -32.100 8.888   1.00 128.34 ? 248 PHE   A CE1 1 
ATOM   1641 C  CE2 . PHE   A 1 227 ? -29.058 -31.479 6.854   1.00 128.33 ? 248 PHE   A CE2 1 
ATOM   1642 C  CZ  . PHE   A 1 227 ? -29.370 -32.437 7.796   1.00 127.51 ? 248 PHE   A CZ  1 
ATOM   1643 N  N   . LEU   A 1 228 ? -27.940 -27.207 8.211   1.00 123.30 ? 249 LEU   A N   1 
ATOM   1644 C  CA  . LEU   A 1 228 ? -26.498 -27.347 8.027   1.00 121.64 ? 249 LEU   A CA  1 
ATOM   1645 C  C   . LEU   A 1 228 ? -25.725 -26.700 9.170   1.00 122.06 ? 249 LEU   A C   1 
ATOM   1646 O  O   . LEU   A 1 228 ? -24.711 -27.244 9.624   1.00 120.97 ? 249 LEU   A O   1 
ATOM   1647 C  CB  . LEU   A 1 228 ? -26.074 -26.754 6.683   1.00 119.20 ? 249 LEU   A CB  1 
ATOM   1648 C  CG  . LEU   A 1 228 ? -25.794 -27.755 5.557   1.00 118.27 ? 249 LEU   A CG  1 
ATOM   1649 C  CD1 . LEU   A 1 228 ? -27.009 -28.619 5.289   1.00 122.82 ? 249 LEU   A CD1 1 
ATOM   1650 C  CD2 . LEU   A 1 228 ? -25.360 -27.045 4.284   1.00 117.93 ? 249 LEU   A CD2 1 
ATOM   1651 N  N   . ARG   A 1 229 ? -26.185 -25.540 9.649   1.00 123.10 ? 250 ARG   A N   1 
ATOM   1652 C  CA  . ARG   A 1 229 ? -25.505 -24.883 10.762  1.00 121.29 ? 250 ARG   A CA  1 
ATOM   1653 C  C   . ARG   A 1 229 ? -25.536 -25.750 12.013  1.00 122.07 ? 250 ARG   A C   1 
ATOM   1654 O  O   . ARG   A 1 229 ? -24.533 -25.858 12.729  1.00 119.42 ? 250 ARG   A O   1 
ATOM   1655 C  CB  . ARG   A 1 229 ? -26.141 -23.520 11.040  1.00 118.13 ? 250 ARG   A CB  1 
ATOM   1656 N  N   . LYS   A 1 230 ? -26.682 -26.376 12.294  1.00 123.36 ? 251 LYS   A N   1 
ATOM   1657 C  CA  . LYS   A 1 230 ? -26.776 -27.254 13.455  1.00 122.49 ? 251 LYS   A CA  1 
ATOM   1658 C  C   . LYS   A 1 230 ? -26.046 -28.570 13.219  1.00 121.32 ? 251 LYS   A C   1 
ATOM   1659 O  O   . LYS   A 1 230 ? -25.458 -29.134 14.150  1.00 119.93 ? 251 LYS   A O   1 
ATOM   1660 C  CB  . LYS   A 1 230 ? -28.244 -27.510 13.803  1.00 123.31 ? 251 LYS   A CB  1 
ATOM   1661 N  N   . SER   A 1 231 ? -26.082 -29.080 11.983  1.00 122.16 ? 252 SER   A N   1 
ATOM   1662 C  CA  . SER   A 1 231 ? -25.445 -30.361 11.692  1.00 122.47 ? 252 SER   A CA  1 
ATOM   1663 C  C   . SER   A 1 231 ? -23.938 -30.299 11.909  1.00 120.39 ? 252 SER   A C   1 
ATOM   1664 O  O   . SER   A 1 231 ? -23.350 -31.220 12.487  1.00 117.52 ? 252 SER   A O   1 
ATOM   1665 C  CB  . SER   A 1 231 ? -25.759 -30.791 10.259  1.00 122.57 ? 252 SER   A CB  1 
ATOM   1666 O  OG  . SER   A 1 231 ? -25.085 -31.995 9.935   1.00 122.59 ? 252 SER   A OG  1 
ATOM   1667 N  N   . VAL   A 1 232 ? -23.297 -29.216 11.458  1.00 120.71 ? 253 VAL   A N   1 
ATOM   1668 C  CA  . VAL   A 1 232 ? -21.851 -29.080 11.614  1.00 120.51 ? 253 VAL   A CA  1 
ATOM   1669 C  C   . VAL   A 1 232 ? -21.470 -29.010 13.087  1.00 122.64 ? 253 VAL   A C   1 
ATOM   1670 O  O   . VAL   A 1 232 ? -20.408 -29.504 13.487  1.00 122.44 ? 253 VAL   A O   1 
ATOM   1671 C  CB  . VAL   A 1 232 ? -21.346 -27.849 10.832  1.00 118.13 ? 253 VAL   A CB  1 
ATOM   1672 C  CG1 . VAL   A 1 232 ? -19.855 -27.637 11.059  1.00 115.41 ? 253 VAL   A CG1 1 
ATOM   1673 C  CG2 . VAL   A 1 232 ? -21.635 -28.010 9.346   1.00 115.03 ? 253 VAL   A CG2 1 
ATOM   1674 N  N   . LYS   A 1 233 ? -22.325 -28.405 13.917  1.00 120.79 ? 254 LYS   A N   1 
ATOM   1675 C  CA  . LYS   A 1 233 ? -22.045 -28.334 15.347  1.00 118.45 ? 254 LYS   A CA  1 
ATOM   1676 C  C   . LYS   A 1 233 ? -21.947 -29.726 15.961  1.00 121.22 ? 254 LYS   A C   1 
ATOM   1677 O  O   . LYS   A 1 233 ? -21.059 -29.989 16.782  1.00 121.60 ? 254 LYS   A O   1 
ATOM   1678 C  CB  . LYS   A 1 233 ? -23.125 -27.514 16.052  1.00 117.41 ? 254 LYS   A CB  1 
ATOM   1679 N  N   . ARG   A 1 234 ? -22.853 -30.629 15.579  1.00 121.14 ? 255 ARG   A N   1 
ATOM   1680 C  CA  . ARG   A 1 234 ? -22.804 -31.993 16.097  1.00 121.02 ? 255 ARG   A CA  1 
ATOM   1681 C  C   . ARG   A 1 234 ? -21.555 -32.724 15.617  1.00 120.90 ? 255 ARG   A C   1 
ATOM   1682 O  O   . ARG   A 1 234 ? -20.945 -33.485 16.378  1.00 118.42 ? 255 ARG   A O   1 
ATOM   1683 C  CB  . ARG   A 1 234 ? -24.066 -32.754 15.691  1.00 113.96 ? 255 ARG   A CB  1 
ATOM   1684 N  N   . MET   A 1 235 ? -21.164 -32.516 14.356  1.00 121.83 ? 256 MET   A N   1 
ATOM   1685 C  CA  . MET   A 1 235 ? -19.951 -33.149 13.846  1.00 122.89 ? 256 MET   A CA  1 
ATOM   1686 C  C   . MET   A 1 235 ? -18.716 -32.664 14.595  1.00 122.44 ? 256 MET   A C   1 
ATOM   1687 O  O   . MET   A 1 235 ? -17.832 -33.461 14.932  1.00 121.42 ? 256 MET   A O   1 
ATOM   1688 C  CB  . MET   A 1 235 ? -19.806 -32.890 12.346  1.00 122.27 ? 256 MET   A CB  1 
ATOM   1689 C  CG  . MET   A 1 235 ? -20.440 -33.956 11.462  1.00 122.70 ? 256 MET   A CG  1 
ATOM   1690 S  SD  . MET   A 1 235 ? -22.006 -33.453 10.722  1.00 126.40 ? 256 MET   A SD  1 
ATOM   1691 C  CE  . MET   A 1 235 ? -21.453 -32.191 9.578   1.00 121.73 ? 256 MET   A CE  1 
ATOM   1692 N  N   . LYS   A 1 236 ? -18.634 -31.357 14.862  1.00 122.63 ? 257 LYS   A N   1 
ATOM   1693 C  CA  . LYS   A 1 236 ? -17.528 -30.837 15.659  1.00 122.96 ? 257 LYS   A CA  1 
ATOM   1694 C  C   . LYS   A 1 236 ? -17.570 -31.376 17.082  1.00 124.86 ? 257 LYS   A C   1 
ATOM   1695 O  O   . LYS   A 1 236 ? -16.519 -31.549 17.711  1.00 124.68 ? 257 LYS   A O   1 
ATOM   1696 C  CB  . LYS   A 1 236 ? -17.556 -29.308 15.669  1.00 120.37 ? 257 LYS   A CB  1 
ATOM   1697 N  N   . GLU   A 1 237 ? -18.770 -31.635 17.608  1.00 125.39 ? 258 GLU   A N   1 
ATOM   1698 C  CA  . GLU   A 1 237 ? -18.885 -32.260 18.921  1.00 124.20 ? 258 GLU   A CA  1 
ATOM   1699 C  C   . GLU   A 1 237 ? -18.288 -33.661 18.915  1.00 125.69 ? 258 GLU   A C   1 
ATOM   1700 O  O   . GLU   A 1 237 ? -17.620 -34.064 19.875  1.00 126.96 ? 258 GLU   A O   1 
ATOM   1701 C  CB  . GLU   A 1 237 ? -20.349 -32.299 19.359  1.00 118.06 ? 258 GLU   A CB  1 
ATOM   1702 N  N   . SER   A 1 238 ? -18.519 -34.419 17.840  1.00 124.68 ? 259 SER   A N   1 
ATOM   1703 C  CA  . SER   A 1 238 ? -17.934 -35.752 17.736  1.00 123.54 ? 259 SER   A CA  1 
ATOM   1704 C  C   . SER   A 1 238 ? -16.415 -35.693 17.660  1.00 122.46 ? 259 SER   A C   1 
ATOM   1705 O  O   . SER   A 1 238 ? -15.734 -36.631 18.091  1.00 124.55 ? 259 SER   A O   1 
ATOM   1706 C  CB  . SER   A 1 238 ? -18.501 -36.479 16.516  1.00 121.83 ? 259 SER   A CB  1 
ATOM   1707 N  N   . ARG   A 1 239 ? -15.867 -34.608 17.123  1.00 121.54 ? 260 ARG   A N   1 
ATOM   1708 C  CA  . ARG   A 1 239 ? -14.423 -34.437 17.034  1.00 122.63 ? 260 ARG   A CA  1 
ATOM   1709 C  C   . ARG   A 1 239 ? -13.810 -34.248 18.417  1.00 120.75 ? 260 ARG   A C   1 
ATOM   1710 O  O   . ARG   A 1 239 ? -12.771 -34.830 18.730  1.00 122.46 ? 260 ARG   A O   1 
ATOM   1711 C  CB  . ARG   A 1 239 ? -14.078 -33.246 16.138  1.00 123.04 ? 260 ARG   A CB  1 
ATOM   1712 N  N   . HIS   A 1 246 ? -9.264  -41.655 12.045  1.00 123.51 ? 267 HIS   A N   1 
ATOM   1713 C  CA  . HIS   A 1 246 ? -8.753  -40.484 11.341  1.00 128.44 ? 267 HIS   A CA  1 
ATOM   1714 C  C   . HIS   A 1 246 ? -9.726  -40.031 10.255  1.00 128.08 ? 267 HIS   A C   1 
ATOM   1715 O  O   . HIS   A 1 246 ? -10.512 -40.826 9.743   1.00 129.81 ? 267 HIS   A O   1 
ATOM   1716 C  CB  . HIS   A 1 246 ? -7.381  -40.780 10.730  1.00 123.49 ? 267 HIS   A CB  1 
ATOM   1717 N  N   . ARG   A 1 247 ? -9.670  -38.745 9.912   1.00 122.79 ? 268 ARG   A N   1 
ATOM   1718 C  CA  . ARG   A 1 247 ? -10.549 -38.162 8.910   1.00 124.81 ? 268 ARG   A CA  1 
ATOM   1719 C  C   . ARG   A 1 247 ? -9.739  -37.303 7.950   1.00 124.23 ? 268 ARG   A C   1 
ATOM   1720 O  O   . ARG   A 1 247 ? -8.750  -36.675 8.337   1.00 123.52 ? 268 ARG   A O   1 
ATOM   1721 C  CB  . ARG   A 1 247 ? -11.658 -37.321 9.559   1.00 120.27 ? 268 ARG   A CB  1 
ATOM   1722 N  N   . VAL   A 1 248 ? -10.163 -37.291 6.687   1.00 122.18 ? 269 VAL   A N   1 
ATOM   1723 C  CA  . VAL   A 1 248 ? -9.485  -36.513 5.654   1.00 119.14 ? 269 VAL   A CA  1 
ATOM   1724 C  C   . VAL   A 1 248 ? -10.488 -35.695 4.849   1.00 119.11 ? 269 VAL   A C   1 
ATOM   1725 O  O   . VAL   A 1 248 ? -10.212 -35.314 3.706   1.00 116.22 ? 269 VAL   A O   1 
ATOM   1726 C  CB  . VAL   A 1 248 ? -8.663  -37.424 4.723   1.00 119.53 ? 269 VAL   A CB  1 
ATOM   1727 C  CG1 . VAL   A 1 248 ? -7.457  -37.997 5.457   1.00 119.22 ? 269 VAL   A CG1 1 
ATOM   1728 C  CG2 . VAL   A 1 248 ? -9.535  -38.540 4.165   1.00 121.07 ? 269 VAL   A CG2 1 
ATOM   1729 N  N   . ASP   A 1 249 ? -11.653 -35.414 5.428   1.00 118.99 ? 270 ASP   A N   1 
ATOM   1730 C  CA  . ASP   A 1 249 ? -12.681 -34.680 4.705   1.00 115.72 ? 270 ASP   A CA  1 
ATOM   1731 C  C   . ASP   A 1 249 ? -12.486 -33.170 4.860   1.00 116.06 ? 270 ASP   A C   1 
ATOM   1732 O  O   . ASP   A 1 249 ? -11.628 -32.699 5.611   1.00 114.58 ? 270 ASP   A O   1 
ATOM   1733 C  CB  . ASP   A 1 249 ? -14.078 -35.106 5.169   1.00 115.20 ? 270 ASP   A CB  1 
ATOM   1734 C  CG  . ASP   A 1 249 ? -14.291 -34.921 6.660   1.00 117.03 ? 270 ASP   A CG  1 
ATOM   1735 O  OD1 . ASP   A 1 249 ? -13.420 -34.332 7.326   1.00 118.15 ? 270 ASP   A OD1 1 
ATOM   1736 O  OD2 . ASP   A 1 249 ? -15.339 -35.372 7.169   1.00 116.44 ? 270 ASP   A OD2 1 
ATOM   1737 N  N   . PHE   A 1 250 ? -13.302 -32.407 4.125   1.00 115.91 ? 271 PHE   A N   1 
ATOM   1738 C  CA  . PHE   A 1 250 ? -13.183 -30.950 4.148   1.00 111.30 ? 271 PHE   A CA  1 
ATOM   1739 C  C   . PHE   A 1 250 ? -13.428 -30.392 5.544   1.00 112.12 ? 271 PHE   A C   1 
ATOM   1740 O  O   . PHE   A 1 250 ? -12.698 -29.504 6.002   1.00 110.52 ? 271 PHE   A O   1 
ATOM   1741 C  CB  . PHE   A 1 250 ? -14.160 -30.317 3.155   1.00 109.96 ? 271 PHE   A CB  1 
ATOM   1742 C  CG  . PHE   A 1 250 ? -13.755 -30.461 1.715   1.00 107.48 ? 271 PHE   A CG  1 
ATOM   1743 C  CD1 . PHE   A 1 250 ? -12.548 -29.955 1.265   1.00 103.18 ? 271 PHE   A CD1 1 
ATOM   1744 C  CD2 . PHE   A 1 250 ? -14.599 -31.075 0.803   1.00 106.06 ? 271 PHE   A CD2 1 
ATOM   1745 C  CE1 . PHE   A 1 250 ? -12.179 -30.078 -0.062  1.00 100.54 ? 271 PHE   A CE1 1 
ATOM   1746 C  CE2 . PHE   A 1 250 ? -14.237 -31.201 -0.525  1.00 104.24 ? 271 PHE   A CE2 1 
ATOM   1747 C  CZ  . PHE   A 1 250 ? -13.025 -30.702 -0.958  1.00 101.79 ? 271 PHE   A CZ  1 
ATOM   1748 N  N   . LEU   A 1 251 ? -14.456 -30.895 6.233   1.00 114.35 ? 272 LEU   A N   1 
ATOM   1749 C  CA  . LEU   A 1 251 ? -14.811 -30.350 7.540   1.00 113.95 ? 272 LEU   A CA  1 
ATOM   1750 C  C   . LEU   A 1 251 ? -13.682 -30.533 8.547   1.00 115.16 ? 272 LEU   A C   1 
ATOM   1751 O  O   . LEU   A 1 251 ? -13.369 -29.611 9.309   1.00 113.82 ? 272 LEU   A O   1 
ATOM   1752 C  CB  . LEU   A 1 251 ? -16.097 -31.001 8.047   1.00 113.53 ? 272 LEU   A CB  1 
ATOM   1753 C  CG  . LEU   A 1 251 ? -16.538 -30.662 9.470   1.00 114.47 ? 272 LEU   A CG  1 
ATOM   1754 C  CD1 . LEU   A 1 251 ? -16.665 -29.159 9.664   1.00 114.69 ? 272 LEU   A CD1 1 
ATOM   1755 C  CD2 . LEU   A 1 251 ? -17.851 -31.353 9.775   1.00 118.93 ? 272 LEU   A CD2 1 
ATOM   1756 N  N   . GLN   A 1 252 ? -13.059 -31.714 8.569   1.00 116.88 ? 273 GLN   A N   1 
ATOM   1757 C  CA  . GLN   A 1 252 ? -11.910 -31.909 9.447   1.00 116.97 ? 273 GLN   A CA  1 
ATOM   1758 C  C   . GLN   A 1 252 ? -10.752 -31.012 9.036   1.00 116.00 ? 273 GLN   A C   1 
ATOM   1759 O  O   . GLN   A 1 252 ? -10.086 -30.417 9.889   1.00 118.15 ? 273 GLN   A O   1 
ATOM   1760 C  CB  . GLN   A 1 252 ? -11.476 -33.375 9.448   1.00 115.76 ? 273 GLN   A CB  1 
ATOM   1761 N  N   . LEU   A 1 253 ? -10.508 -30.887 7.728   1.00 114.11 ? 274 LEU   A N   1 
ATOM   1762 C  CA  . LEU   A 1 253 ? -9.398  -30.068 7.254   1.00 114.66 ? 274 LEU   A CA  1 
ATOM   1763 C  C   . LEU   A 1 253 ? -9.563  -28.606 7.649   1.00 113.97 ? 274 LEU   A C   1 
ATOM   1764 O  O   . LEU   A 1 253 ? -8.567  -27.888 7.797   1.00 112.37 ? 274 LEU   A O   1 
ATOM   1765 C  CB  . LEU   A 1 253 ? -9.259  -30.202 5.737   1.00 111.02 ? 274 LEU   A CB  1 
ATOM   1766 C  CG  . LEU   A 1 253 ? -8.635  -31.511 5.248   1.00 108.43 ? 274 LEU   A CG  1 
ATOM   1767 C  CD1 . LEU   A 1 253 ? -8.663  -31.606 3.729   1.00 106.43 ? 274 LEU   A CD1 1 
ATOM   1768 C  CD2 . LEU   A 1 253 ? -7.212  -31.641 5.768   1.00 112.06 ? 274 LEU   A CD2 1 
ATOM   1769 N  N   . MET   A 1 254 ? -10.801 -28.147 7.827   1.00 115.15 ? 275 MET   A N   1 
ATOM   1770 C  CA  . MET   A 1 254 ? -11.035 -26.769 8.238   1.00 114.53 ? 275 MET   A CA  1 
ATOM   1771 C  C   . MET   A 1 254 ? -10.991 -26.599 9.753   1.00 116.12 ? 275 MET   A C   1 
ATOM   1772 O  O   . MET   A 1 254 ? -10.449 -25.603 10.243  1.00 118.32 ? 275 MET   A O   1 
ATOM   1773 C  CB  . MET   A 1 254 ? -12.378 -26.278 7.693   1.00 111.56 ? 275 MET   A CB  1 
ATOM   1774 C  CG  . MET   A 1 254 ? -12.450 -26.221 6.176   1.00 108.54 ? 275 MET   A CG  1 
ATOM   1775 S  SD  . MET   A 1 254 ? -13.985 -25.481 5.590   1.00 105.76 ? 275 MET   A SD  1 
ATOM   1776 C  CE  . MET   A 1 254 ? -13.870 -23.854 6.330   1.00 99.64  ? 275 MET   A CE  1 
ATOM   1777 N  N   . ILE   A 1 255 ? -11.548 -27.550 10.509  1.00 116.06 ? 276 ILE   A N   1 
ATOM   1778 C  CA  . ILE   A 1 255 ? -11.460 -27.466 11.964  1.00 118.00 ? 276 ILE   A CA  1 
ATOM   1779 C  C   . ILE   A 1 255 ? -10.030 -27.713 12.429  1.00 118.97 ? 276 ILE   A C   1 
ATOM   1780 O  O   . ILE   A 1 255 ? -9.613  -27.199 13.475  1.00 119.77 ? 276 ILE   A O   1 
ATOM   1781 C  CB  . ILE   A 1 255 ? -12.449 -28.437 12.640  1.00 116.70 ? 276 ILE   A CB  1 
ATOM   1782 C  CG1 . ILE   A 1 255 ? -12.051 -29.891 12.389  1.00 116.32 ? 276 ILE   A CG1 1 
ATOM   1783 C  CG2 . ILE   A 1 255 ? -13.865 -28.185 12.155  1.00 118.53 ? 276 ILE   A CG2 1 
ATOM   1784 C  CD1 . ILE   A 1 255 ? -12.961 -30.893 13.064  1.00 121.66 ? 276 ILE   A CD1 1 
ATOM   1785 N  N   . ASP   A 1 256 ? -9.259  -28.506 11.678  1.00 117.71 ? 277 ASP   A N   1 
ATOM   1786 C  CA  . ASP   A 1 256 ? -7.841  -28.657 11.990  1.00 118.90 ? 277 ASP   A CA  1 
ATOM   1787 C  C   . ASP   A 1 256 ? -7.100  -27.339 11.805  1.00 120.17 ? 277 ASP   A C   1 
ATOM   1788 O  O   . ASP   A 1 256 ? -6.173  -27.029 12.562  1.00 121.80 ? 277 ASP   A O   1 
ATOM   1789 C  CB  . ASP   A 1 256 ? -7.218  -29.753 11.123  1.00 119.84 ? 277 ASP   A CB  1 
ATOM   1790 C  CG  . ASP   A 1 256 ? -7.743  -31.134 11.464  1.00 119.62 ? 277 ASP   A CG  1 
ATOM   1791 O  OD1 . ASP   A 1 256 ? -8.194  -31.333 12.611  1.00 121.93 ? 277 ASP   A OD1 1 
ATOM   1792 O  OD2 . ASP   A 1 256 ? -7.708  -32.020 10.582  1.00 118.79 ? 277 ASP   A OD2 1 
ATOM   1793 N  N   . SER   A 1 257 ? -7.491  -26.553 10.799  1.00 120.12 ? 278 SER   A N   1 
ATOM   1794 C  CA  . SER   A 1 257 ? -6.926  -25.222 10.623  1.00 120.39 ? 278 SER   A CA  1 
ATOM   1795 C  C   . SER   A 1 257 ? -7.346  -24.264 11.729  1.00 119.27 ? 278 SER   A C   1 
ATOM   1796 O  O   . SER   A 1 257 ? -6.648  -23.273 11.969  1.00 119.26 ? 278 SER   A O   1 
ATOM   1797 C  CB  . SER   A 1 257 ? -7.336  -24.648 9.266   1.00 117.99 ? 278 SER   A CB  1 
ATOM   1798 O  OG  . SER   A 1 257 ? -6.936  -23.294 9.149   1.00 111.62 ? 278 SER   A OG  1 
ATOM   1799 N  N   . GLN   A 1 258 ? -8.470  -24.533 12.399  1.00 118.19 ? 279 GLN   A N   1 
ATOM   1800 C  CA  . GLN   A 1 258 ? -8.906  -23.668 13.491  1.00 119.81 ? 279 GLN   A CA  1 
ATOM   1801 C  C   . GLN   A 1 258 ? -7.908  -23.685 14.643  1.00 123.24 ? 279 GLN   A C   1 
ATOM   1802 O  O   . GLN   A 1 258 ? -7.678  -22.657 15.290  1.00 121.54 ? 279 GLN   A O   1 
ATOM   1803 C  CB  . GLN   A 1 258 ? -10.295 -24.087 13.978  1.00 118.52 ? 279 GLN   A CB  1 
ATOM   1804 C  CG  . GLN   A 1 258 ? -11.424 -23.751 13.014  1.00 113.87 ? 279 GLN   A CG  1 
ATOM   1805 C  CD  . GLN   A 1 258 ? -12.798 -24.046 13.590  1.00 113.67 ? 279 GLN   A CD  1 
ATOM   1806 O  OE1 . GLN   A 1 258 ? -13.022 -25.099 14.188  1.00 115.38 ? 279 GLN   A OE1 1 
ATOM   1807 N  NE2 . GLN   A 1 258 ? -13.725 -23.110 13.417  1.00 112.09 ? 279 GLN   A NE2 1 
ATOM   1808 N  N   . ASN   A 1 259 ? -7.311  -24.844 14.919  1.00 123.14 ? 280 ASN   A N   1 
ATOM   1809 C  CA  . ASN   A 1 259 ? -6.348  -24.957 16.006  1.00 123.45 ? 280 ASN   A CA  1 
ATOM   1810 C  C   . ASN   A 1 259 ? -4.911  -24.723 15.565  1.00 124.70 ? 280 ASN   A C   1 
ATOM   1811 O  O   . ASN   A 1 259 ? -4.059  -24.470 16.425  1.00 129.35 ? 280 ASN   A O   1 
ATOM   1812 C  CB  . ASN   A 1 259 ? -6.449  -26.336 16.666  1.00 122.87 ? 280 ASN   A CB  1 
ATOM   1813 C  CG  . ASN   A 1 259 ? -6.312  -27.472 15.670  1.00 125.76 ? 280 ASN   A CG  1 
ATOM   1814 O  OD1 . ASN   A 1 259 ? -7.308  -28.023 15.203  1.00 123.84 ? 280 ASN   A OD1 1 
ATOM   1815 N  ND2 . ASN   A 1 259 ? -5.075  -27.827 15.339  1.00 125.67 ? 280 ASN   A ND2 1 
ATOM   1816 N  N   . SER   A 1 260 ? -4.638  -24.797 14.260  1.00 122.09 ? 281 SER   A N   1 
ATOM   1817 C  CA  . SER   A 1 260 ? -3.295  -24.720 13.664  1.00 120.06 ? 281 SER   A CA  1 
ATOM   1818 C  C   . SER   A 1 260 ? -2.229  -24.035 14.515  1.00 115.80 ? 281 SER   A C   1 
ATOM   1819 O  O   . SER   A 1 260 ? -2.014  -22.830 14.404  1.00 112.03 ? 281 SER   A O   1 
ATOM   1820 C  CB  . SER   A 1 260 ? -3.376  -24.004 12.313  1.00 120.59 ? 281 SER   A CB  1 
ATOM   1821 N  N   . HIS   A 1 266 ? -2.004  -13.457 9.851   1.00 98.61  ? 287 HIS   A N   1 
ATOM   1822 C  CA  . HIS   A 1 266 ? -2.844  -14.630 9.644   1.00 107.15 ? 287 HIS   A CA  1 
ATOM   1823 C  C   . HIS   A 1 266 ? -3.730  -14.877 10.867  1.00 109.23 ? 287 HIS   A C   1 
ATOM   1824 O  O   . HIS   A 1 266 ? -3.223  -15.170 11.951  1.00 111.35 ? 287 HIS   A O   1 
ATOM   1825 C  CB  . HIS   A 1 266 ? -1.979  -15.863 9.349   1.00 100.98 ? 287 HIS   A CB  1 
ATOM   1826 N  N   . LYS   A 1 267 ? -5.044  -14.736 10.693  1.00 103.68 ? 288 LYS   A N   1 
ATOM   1827 C  CA  . LYS   A 1 267 ? -6.018  -15.025 11.744  1.00 103.60 ? 288 LYS   A CA  1 
ATOM   1828 C  C   . LYS   A 1 267 ? -6.613  -16.412 11.513  1.00 104.97 ? 288 LYS   A C   1 
ATOM   1829 O  O   . LYS   A 1 267 ? -6.156  -17.167 10.652  1.00 106.48 ? 288 LYS   A O   1 
ATOM   1830 C  CB  . LYS   A 1 267 ? -7.097  -13.942 11.782  1.00 101.55 ? 288 LYS   A CB  1 
ATOM   1831 N  N   . ALA   A 1 268 ? -7.637  -16.760 12.280  1.00 102.95 ? 289 ALA   A N   1 
ATOM   1832 C  CA  . ALA   A 1 268 ? -8.208  -18.100 12.250  1.00 103.40 ? 289 ALA   A CA  1 
ATOM   1833 C  C   . ALA   A 1 268 ? -9.675  -18.057 11.839  1.00 105.00 ? 289 ALA   A C   1 
ATOM   1834 O  O   . ALA   A 1 268 ? -10.287 -16.990 11.741  1.00 106.94 ? 289 ALA   A O   1 
ATOM   1835 C  CB  . ALA   A 1 268 ? -8.052  -18.781 13.612  1.00 105.63 ? 289 ALA   A CB  1 
ATOM   1836 N  N   . LEU   A 1 269 ? -10.237 -19.243 11.614  1.00 103.09 ? 290 LEU   A N   1 
ATOM   1837 C  CA  . LEU   A 1 269 ? -11.594 -19.399 11.100  1.00 104.58 ? 290 LEU   A CA  1 
ATOM   1838 C  C   . LEU   A 1 269 ? -12.572 -19.621 12.246  1.00 106.86 ? 290 LEU   A C   1 
ATOM   1839 O  O   . LEU   A 1 269 ? -12.347 -20.490 13.096  1.00 111.88 ? 290 LEU   A O   1 
ATOM   1840 C  CB  . LEU   A 1 269 ? -11.657 -20.583 10.128  1.00 104.74 ? 290 LEU   A CB  1 
ATOM   1841 C  CG  . LEU   A 1 269 ? -11.626 -20.275 8.632   1.00 99.79  ? 290 LEU   A CG  1 
ATOM   1842 C  CD1 . LEU   A 1 269 ? -11.317 -21.530 7.836   1.00 98.17  ? 290 LEU   A CD1 1 
ATOM   1843 C  CD2 . LEU   A 1 269 ? -12.954 -19.686 8.200   1.00 102.13 ? 290 LEU   A CD2 1 
ATOM   1844 N  N   . SER   A 1 270 ? -13.661 -18.855 12.255  1.00 105.10 ? 291 SER   A N   1 
ATOM   1845 C  CA  . SER   A 1 270 ? -14.695 -19.018 13.264  1.00 105.26 ? 291 SER   A CA  1 
ATOM   1846 C  C   . SER   A 1 270 ? -15.637 -20.162 12.889  1.00 104.67 ? 291 SER   A C   1 
ATOM   1847 O  O   . SER   A 1 270 ? -15.736 -20.569 11.728  1.00 105.18 ? 291 SER   A O   1 
ATOM   1848 C  CB  . SER   A 1 270 ? -15.492 -17.725 13.452  1.00 103.57 ? 291 SER   A CB  1 
ATOM   1849 O  OG  . SER   A 1 270 ? -16.489 -17.585 12.456  1.00 102.33 ? 291 SER   A OG  1 
ATOM   1850 N  N   . ASP   A 1 271 ? -16.332 -20.686 13.901  1.00 105.47 ? 292 ASP   A N   1 
ATOM   1851 C  CA  . ASP   A 1 271 ? -17.246 -21.795 13.672  1.00 107.84 ? 292 ASP   A CA  1 
ATOM   1852 C  C   . ASP   A 1 271 ? -18.492 -21.373 12.904  1.00 106.54 ? 292 ASP   A C   1 
ATOM   1853 O  O   . ASP   A 1 271 ? -19.178 -22.233 12.341  1.00 107.05 ? 292 ASP   A O   1 
ATOM   1854 C  CB  . ASP   A 1 271 ? -17.636 -22.441 15.002  1.00 111.28 ? 292 ASP   A CB  1 
ATOM   1855 C  CG  . ASP   A 1 271 ? -16.438 -23.008 15.742  1.00 113.26 ? 292 ASP   A CG  1 
ATOM   1856 O  OD1 . ASP   A 1 271 ? -15.301 -22.592 15.437  1.00 109.95 ? 292 ASP   A OD1 1 
ATOM   1857 O  OD2 . ASP   A 1 271 ? -16.631 -23.877 16.618  1.00 114.85 ? 292 ASP   A OD2 1 
ATOM   1858 N  N   . LEU   A 1 272 ? -18.804 -20.076 12.873  1.00 104.61 ? 293 LEU   A N   1 
ATOM   1859 C  CA  . LEU   A 1 272 ? -19.854 -19.588 11.985  1.00 103.13 ? 293 LEU   A CA  1 
ATOM   1860 C  C   . LEU   A 1 272 ? -19.323 -19.342 10.579  1.00 102.73 ? 293 LEU   A C   1 
ATOM   1861 O  O   . LEU   A 1 272 ? -20.044 -19.565 9.600   1.00 103.58 ? 293 LEU   A O   1 
ATOM   1862 C  CB  . LEU   A 1 272 ? -20.478 -18.310 12.550  1.00 100.59 ? 293 LEU   A CB  1 
ATOM   1863 N  N   . GLU   A 1 273 ? -18.075 -18.882 10.460  1.00 101.27 ? 294 GLU   A N   1 
ATOM   1864 C  CA  . GLU   A 1 273 ? -17.439 -18.800 9.150   1.00 101.31 ? 294 GLU   A CA  1 
ATOM   1865 C  C   . GLU   A 1 273 ? -17.261 -20.184 8.542   1.00 100.45 ? 294 GLU   A C   1 
ATOM   1866 O  O   . GLU   A 1 273 ? -17.473 -20.375 7.340   1.00 100.16 ? 294 GLU   A O   1 
ATOM   1867 C  CB  . GLU   A 1 273 ? -16.087 -18.097 9.258   1.00 102.73 ? 294 GLU   A CB  1 
ATOM   1868 C  CG  . GLU   A 1 273 ? -16.157 -16.594 9.454   1.00 103.68 ? 294 GLU   A CG  1 
ATOM   1869 C  CD  . GLU   A 1 273 ? -14.789 -15.982 9.682   1.00 104.62 ? 294 GLU   A CD  1 
ATOM   1870 O  OE1 . GLU   A 1 273 ? -13.847 -16.740 9.997   1.00 104.64 ? 294 GLU   A OE1 1 
ATOM   1871 O  OE2 . GLU   A 1 273 ? -14.654 -14.747 9.543   1.00 105.13 ? 294 GLU   A OE2 1 
ATOM   1872 N  N   . LEU   A 1 274 ? -16.871 -21.162 9.363   1.00 102.05 ? 295 LEU   A N   1 
ATOM   1873 C  CA  . LEU   A 1 274 ? -16.618 -22.510 8.863   1.00 102.58 ? 295 LEU   A CA  1 
ATOM   1874 C  C   . LEU   A 1 274 ? -17.864 -23.110 8.224   1.00 101.05 ? 295 LEU   A C   1 
ATOM   1875 O  O   . LEU   A 1 274 ? -17.780 -23.761 7.176   1.00 100.27 ? 295 LEU   A O   1 
ATOM   1876 C  CB  . LEU   A 1 274 ? -16.115 -23.395 10.003  1.00 103.87 ? 295 LEU   A CB  1 
ATOM   1877 C  CG  . LEU   A 1 274 ? -16.422 -24.895 9.982   1.00 103.19 ? 295 LEU   A CG  1 
ATOM   1878 C  CD1 . LEU   A 1 274 ? -15.658 -25.620 8.888   1.00 102.24 ? 295 LEU   A CD1 1 
ATOM   1879 C  CD2 . LEU   A 1 274 ? -16.111 -25.498 11.339  1.00 107.58 ? 295 LEU   A CD2 1 
ATOM   1880 N  N   . VAL   A 1 275 ? -19.029 -22.909 8.843   1.00 101.04 ? 296 VAL   A N   1 
ATOM   1881 C  CA  . VAL   A 1 275 ? -20.268 -23.439 8.281   1.00 100.79 ? 296 VAL   A CA  1 
ATOM   1882 C  C   . VAL   A 1 275 ? -20.561 -22.789 6.935   1.00 98.97  ? 296 VAL   A C   1 
ATOM   1883 O  O   . VAL   A 1 275 ? -20.800 -23.475 5.935   1.00 96.95  ? 296 VAL   A O   1 
ATOM   1884 C  CB  . VAL   A 1 275 ? -21.432 -23.242 9.268   1.00 103.90 ? 296 VAL   A CB  1 
ATOM   1885 C  CG1 . VAL   A 1 275 ? -22.743 -23.661 8.626   1.00 105.54 ? 296 VAL   A CG1 1 
ATOM   1886 C  CG2 . VAL   A 1 275 ? -21.182 -24.030 10.543  1.00 106.17 ? 296 VAL   A CG2 1 
ATOM   1887 N  N   . ALA   A 1 276 ? -20.521 -21.455 6.884   1.00 101.32 ? 297 ALA   A N   1 
ATOM   1888 C  CA  . ALA   A 1 276 ? -20.816 -20.752 5.639   1.00 98.03  ? 297 ALA   A CA  1 
ATOM   1889 C  C   . ALA   A 1 276 ? -19.786 -21.060 4.561   1.00 96.18  ? 297 ALA   A C   1 
ATOM   1890 O  O   . ALA   A 1 276 ? -20.123 -21.100 3.372   1.00 95.34  ? 297 ALA   A O   1 
ATOM   1891 C  CB  . ALA   A 1 276 ? -20.889 -19.245 5.887   1.00 94.67  ? 297 ALA   A CB  1 
ATOM   1892 N  N   . GLN   A 1 277 ? -18.527 -21.269 4.954   1.00 94.74  ? 298 GLN   A N   1 
ATOM   1893 C  CA  . GLN   A 1 277 ? -17.502 -21.637 3.984   1.00 91.88  ? 298 GLN   A CA  1 
ATOM   1894 C  C   . GLN   A 1 277 ? -17.805 -22.984 3.341   1.00 93.66  ? 298 GLN   A C   1 
ATOM   1895 O  O   . GLN   A 1 277 ? -17.668 -23.145 2.123   1.00 96.47  ? 298 GLN   A O   1 
ATOM   1896 C  CB  . GLN   A 1 277 ? -16.129 -21.667 4.654   1.00 95.24  ? 298 GLN   A CB  1 
ATOM   1897 C  CG  . GLN   A 1 277 ? -15.526 -20.300 4.898   1.00 96.08  ? 298 GLN   A CG  1 
ATOM   1898 C  CD  . GLN   A 1 277 ? -15.434 -19.482 3.631   1.00 95.03  ? 298 GLN   A CD  1 
ATOM   1899 O  OE1 . GLN   A 1 277 ? -15.156 -20.012 2.555   1.00 93.29  ? 298 GLN   A OE1 1 
ATOM   1900 N  NE2 . GLN   A 1 277 ? -15.678 -18.184 3.747   1.00 95.78  ? 298 GLN   A NE2 1 
ATOM   1901 N  N   . SER   A 1 278 ? -18.222 -23.966 4.143   1.00 94.36  ? 299 SER   A N   1 
ATOM   1902 C  CA  . SER   A 1 278 ? -18.432 -25.308 3.613   1.00 93.37  ? 299 SER   A CA  1 
ATOM   1903 C  C   . SER   A 1 278 ? -19.710 -25.403 2.790   1.00 93.91  ? 299 SER   A C   1 
ATOM   1904 O  O   . SER   A 1 278 ? -19.813 -26.270 1.914   1.00 95.30  ? 299 SER   A O   1 
ATOM   1905 C  CB  . SER   A 1 278 ? -18.464 -26.325 4.755   1.00 97.93  ? 299 SER   A CB  1 
ATOM   1906 O  OG  . SER   A 1 278 ? -19.539 -26.058 5.637   1.00 98.86  ? 299 SER   A OG  1 
ATOM   1907 N  N   . ILE   A 1 279 ? -20.694 -24.541 3.061   1.00 97.47  ? 300 ILE   A N   1 
ATOM   1908 C  CA  . ILE   A 1 279 ? -21.963 -24.609 2.339   1.00 94.93  ? 300 ILE   A CA  1 
ATOM   1909 C  C   . ILE   A 1 279 ? -21.754 -24.335 0.855   1.00 91.32  ? 300 ILE   A C   1 
ATOM   1910 O  O   . ILE   A 1 279 ? -22.315 -25.028 -0.004  1.00 93.00  ? 300 ILE   A O   1 
ATOM   1911 C  CB  . ILE   A 1 279 ? -22.987 -23.639 2.958   1.00 96.48  ? 300 ILE   A CB  1 
ATOM   1912 C  CG1 . ILE   A 1 279 ? -23.356 -24.080 4.376   1.00 97.04  ? 300 ILE   A CG1 1 
ATOM   1913 C  CG2 . ILE   A 1 279 ? -24.237 -23.567 2.100   1.00 99.83  ? 300 ILE   A CG2 1 
ATOM   1914 C  CD1 . ILE   A 1 279 ? -24.312 -23.144 5.085   1.00 101.30 ? 300 ILE   A CD1 1 
ATOM   1915 N  N   . ILE   A 1 280 ? -20.942 -23.327 0.524   1.00 92.15  ? 301 ILE   A N   1 
ATOM   1916 C  CA  . ILE   A 1 280 ? -20.718 -23.010 -0.881  1.00 93.22  ? 301 ILE   A CA  1 
ATOM   1917 C  C   . ILE   A 1 280 ? -19.932 -24.105 -1.588  1.00 93.20  ? 301 ILE   A C   1 
ATOM   1918 O  O   . ILE   A 1 280 ? -19.994 -24.207 -2.818  1.00 94.41  ? 301 ILE   A O   1 
ATOM   1919 C  CB  . ILE   A 1 280 ? -20.009 -21.652 -1.041  1.00 90.44  ? 301 ILE   A CB  1 
ATOM   1920 C  CG1 . ILE   A 1 280 ? -18.503 -21.801 -0.835  1.00 87.49  ? 301 ILE   A CG1 1 
ATOM   1921 C  CG2 . ILE   A 1 280 ? -20.582 -20.638 -0.070  1.00 92.91  ? 301 ILE   A CG2 1 
ATOM   1922 C  CD1 . ILE   A 1 280 ? -17.699 -20.736 -1.529  1.00 87.83  ? 301 ILE   A CD1 1 
ATOM   1923 N  N   . PHE   A 1 281 ? -19.182 -24.927 -0.848  1.00 92.67  ? 302 PHE   A N   1 
ATOM   1924 C  CA  . PHE   A 1 281 ? -18.533 -26.079 -1.465  1.00 92.47  ? 302 PHE   A CA  1 
ATOM   1925 C  C   . PHE   A 1 281 ? -19.572 -27.052 -2.003  1.00 90.57  ? 302 PHE   A C   1 
ATOM   1926 O  O   . PHE   A 1 281 ? -19.447 -27.560 -3.124  1.00 89.61  ? 302 PHE   A O   1 
ATOM   1927 C  CB  . PHE   A 1 281 ? -17.616 -26.777 -0.459  1.00 92.89  ? 302 PHE   A CB  1 
ATOM   1928 C  CG  . PHE   A 1 281 ? -16.491 -25.917 0.044   1.00 92.44  ? 302 PHE   A CG  1 
ATOM   1929 C  CD1 . PHE   A 1 281 ? -16.058 -24.818 -0.678  1.00 92.19  ? 302 PHE   A CD1 1 
ATOM   1930 C  CD2 . PHE   A 1 281 ? -15.864 -26.215 1.243   1.00 97.22  ? 302 PHE   A CD2 1 
ATOM   1931 C  CE1 . PHE   A 1 281 ? -15.024 -24.030 -0.213  1.00 90.74  ? 302 PHE   A CE1 1 
ATOM   1932 C  CE2 . PHE   A 1 281 ? -14.830 -25.432 1.712   1.00 94.47  ? 302 PHE   A CE2 1 
ATOM   1933 C  CZ  . PHE   A 1 281 ? -14.410 -24.338 0.984   1.00 94.02  ? 302 PHE   A CZ  1 
ATOM   1934 N  N   . ILE   A 1 282 ? -20.611 -27.322 -1.209  1.00 90.21  ? 303 ILE   A N   1 
ATOM   1935 C  CA  . ILE   A 1 282 ? -21.719 -28.144 -1.684  1.00 89.55  ? 303 ILE   A CA  1 
ATOM   1936 C  C   . ILE   A 1 282 ? -22.459 -27.435 -2.808  1.00 91.50  ? 303 ILE   A C   1 
ATOM   1937 O  O   . ILE   A 1 282 ? -22.859 -28.057 -3.798  1.00 93.34  ? 303 ILE   A O   1 
ATOM   1938 C  CB  . ILE   A 1 282 ? -22.662 -28.498 -0.519  1.00 82.73  ? 303 ILE   A CB  1 
ATOM   1939 N  N   . PHE   A 1 283 ? -22.626 -26.126 -2.654  1.00 90.20  ? 304 PHE   A N   1 
ATOM   1940 C  CA  . PHE   A 1 283 ? -23.326 -25.340 -3.699  1.00 92.52  ? 304 PHE   A CA  1 
ATOM   1941 C  C   . PHE   A 1 283 ? -22.577 -25.495 -5.004  1.00 93.83  ? 304 PHE   A C   1 
ATOM   1942 O  O   . PHE   A 1 283 ? -23.172 -25.902 -6.021  1.00 94.95  ? 304 PHE   A O   1 
ATOM   1943 C  CB  . PHE   A 1 283 ? -23.374 -23.872 -3.281  1.00 93.08  ? 304 PHE   A CB  1 
ATOM   1944 C  CG  . PHE   A 1 283 ? -24.235 -22.988 -4.169  1.00 98.05  ? 304 PHE   A CG  1 
ATOM   1945 C  CD1 . PHE   A 1 283 ? -25.611 -23.162 -4.226  1.00 102.62 ? 304 PHE   A CD1 1 
ATOM   1946 C  CD2 . PHE   A 1 283 ? -23.666 -21.986 -4.943  1.00 97.42  ? 304 PHE   A CD2 1 
ATOM   1947 C  CE1 . PHE   A 1 283 ? -26.392 -22.355 -5.036  1.00 107.52 ? 304 PHE   A CE1 1 
ATOM   1948 C  CE2 . PHE   A 1 283 ? -24.453 -21.183 -5.750  1.00 99.49  ? 304 PHE   A CE2 1 
ATOM   1949 C  CZ  . PHE   A 1 283 ? -25.812 -21.367 -5.795  1.00 102.32 ? 304 PHE   A CZ  1 
ATOM   1950 N  N   . ALA   A 1 284 ? -21.284 -25.184 -4.981  1.00 94.05  ? 305 ALA   A N   1 
ATOM   1951 C  CA  . ALA   A 1 284 ? -20.491 -25.246 -6.203  1.00 90.34  ? 305 ALA   A CA  1 
ATOM   1952 C  C   . ALA   A 1 284 ? -20.295 -26.685 -6.666  1.00 90.67  ? 305 ALA   A C   1 
ATOM   1953 O  O   . ALA   A 1 284 ? -20.411 -26.980 -7.860  1.00 90.04  ? 305 ALA   A O   1 
ATOM   1954 C  CB  . ALA   A 1 284 ? -19.142 -24.560 -5.989  1.00 84.69  ? 305 ALA   A CB  1 
ATOM   1955 N  N   . GLY   A 1 285 ? -20.007 -27.596 -5.736  1.00 91.83  ? 306 GLY   A N   1 
ATOM   1956 C  CA  . GLY   A 1 285 ? -19.688 -28.960 -6.125  1.00 94.56  ? 306 GLY   A CA  1 
ATOM   1957 C  C   . GLY   A 1 285 ? -20.862 -29.707 -6.730  1.00 99.68  ? 306 GLY   A C   1 
ATOM   1958 O  O   . GLY   A 1 285 ? -20.694 -30.472 -7.683  1.00 100.58 ? 306 GLY   A O   1 
ATOM   1959 N  N   . TYR   A 1 286 ? -22.065 -29.496 -6.193  1.00 100.67 ? 307 TYR   A N   1 
ATOM   1960 C  CA  . TYR   A 1 286 ? -23.211 -30.312 -6.588  1.00 100.80 ? 307 TYR   A CA  1 
ATOM   1961 C  C   . TYR   A 1 286 ? -23.666 -29.991 -8.009  1.00 96.92  ? 307 TYR   A C   1 
ATOM   1962 O  O   . TYR   A 1 286 ? -23.626 -30.851 -8.897  1.00 95.91  ? 307 TYR   A O   1 
ATOM   1963 C  CB  . TYR   A 1 286 ? -24.357 -30.115 -5.593  1.00 102.56 ? 307 TYR   A CB  1 
ATOM   1964 C  CG  . TYR   A 1 286 ? -25.623 -30.870 -5.935  1.00 108.66 ? 307 TYR   A CG  1 
ATOM   1965 C  CD1 . TYR   A 1 286 ? -25.789 -32.194 -5.552  1.00 112.40 ? 307 TYR   A CD1 1 
ATOM   1966 C  CD2 . TYR   A 1 286 ? -26.656 -30.254 -6.631  1.00 109.66 ? 307 TYR   A CD2 1 
ATOM   1967 C  CE1 . TYR   A 1 286 ? -26.946 -32.886 -5.860  1.00 113.44 ? 307 TYR   A CE1 1 
ATOM   1968 C  CE2 . TYR   A 1 286 ? -27.816 -30.939 -6.945  1.00 109.59 ? 307 TYR   A CE2 1 
ATOM   1969 C  CZ  . TYR   A 1 286 ? -27.955 -32.255 -6.557  1.00 113.20 ? 307 TYR   A CZ  1 
ATOM   1970 O  OH  . TYR   A 1 286 ? -29.106 -32.943 -6.864  1.00 119.80 ? 307 TYR   A OH  1 
ATOM   1971 N  N   . GLU   A 1 287 ? -24.099 -28.749 -8.245  1.00 97.10  ? 308 GLU   A N   1 
ATOM   1972 C  CA  . GLU   A 1 287 ? -24.739 -28.411 -9.515  1.00 96.79  ? 308 GLU   A CA  1 
ATOM   1973 C  C   . GLU   A 1 287 ? -23.748 -28.443 -10.673 1.00 94.41  ? 308 GLU   A C   1 
ATOM   1974 O  O   . GLU   A 1 287 ? -24.077 -28.927 -11.764 1.00 92.78  ? 308 GLU   A O   1 
ATOM   1975 C  CB  . GLU   A 1 287 ? -25.402 -27.036 -9.416  1.00 99.54  ? 308 GLU   A CB  1 
ATOM   1976 C  CG  . GLU   A 1 287 ? -26.383 -26.727 -10.540 1.00 102.00 ? 308 GLU   A CG  1 
ATOM   1977 C  CD  . GLU   A 1 287 ? -27.804 -27.161 -10.221 1.00 105.64 ? 308 GLU   A CD  1 
ATOM   1978 O  OE1 . GLU   A 1 287 ? -27.999 -27.906 -9.237  1.00 107.29 ? 308 GLU   A OE1 1 
ATOM   1979 O  OE2 . GLU   A 1 287 ? -28.729 -26.747 -10.952 1.00 108.05 ? 308 GLU   A OE2 1 
ATOM   1980 N  N   . THR   A 1 288 ? -22.538 -27.944 -10.442 1.00 96.79  ? 309 THR   A N   1 
ATOM   1981 C  CA  . THR   A 1 288 ? -21.557 -27.863 -11.539 1.00 95.51  ? 309 THR   A CA  1 
ATOM   1982 C  C   . THR   A 1 288 ? -21.258 -29.259 -12.026 1.00 93.62  ? 309 THR   A C   1 
ATOM   1983 O  O   . THR   A 1 288 ? -21.533 -29.554 -13.204 1.00 93.50  ? 309 THR   A O   1 
ATOM   1984 C  CB  . THR   A 1 288 ? -20.300 -27.162 -11.037 1.00 89.13  ? 309 THR   A CB  1 
ATOM   1985 O  OG1 . THR   A 1 288 ? -19.887 -27.941 -9.919  1.00 88.69  ? 309 THR   A OG1 1 
ATOM   1986 C  CG2 . THR   A 1 288 ? -20.563 -25.723 -10.633 1.00 84.71  ? 309 THR   A CG2 1 
ATOM   1987 N  N   . THR   A 1 289 ? -20.711 -30.091 -11.145 1.00 92.67  ? 310 THR   A N   1 
ATOM   1988 C  CA  . THR   A 1 289 ? -20.223 -31.412 -11.531 1.00 94.80  ? 310 THR   A CA  1 
ATOM   1989 C  C   . THR   A 1 289 ? -21.248 -32.160 -12.368 1.00 95.35  ? 310 THR   A C   1 
ATOM   1990 O  O   . THR   A 1 289 ? -20.931 -32.664 -13.452 1.00 94.02  ? 310 THR   A O   1 
ATOM   1991 C  CB  . THR   A 1 289 ? -19.860 -32.221 -10.281 1.00 97.35  ? 310 THR   A CB  1 
ATOM   1992 O  OG1 . THR   A 1 289 ? -18.778 -31.572 -9.598  1.00 97.08  ? 310 THR   A OG1 1 
ATOM   1993 C  CG2 . THR   A 1 289 ? -19.447 -33.638 -10.653 1.00 99.05  ? 310 THR   A CG2 1 
ATOM   1994 N  N   . SER   A 1 290 ? -22.487 -32.240 -11.878 1.00 97.98  ? 311 SER   A N   1 
ATOM   1995 C  CA  . SER   A 1 290 ? -23.523 -32.968 -12.601 1.00 96.03  ? 311 SER   A CA  1 
ATOM   1996 C  C   . SER   A 1 290 ? -23.790 -32.339 -13.963 1.00 91.42  ? 311 SER   A C   1 
ATOM   1997 O  O   . SER   A 1 290 ? -23.933 -33.045 -14.967 1.00 92.74  ? 311 SER   A O   1 
ATOM   1998 C  CB  . SER   A 1 290 ? -24.806 -33.003 -11.770 1.00 94.83  ? 311 SER   A CB  1 
ATOM   1999 O  OG  . SER   A 1 290 ? -25.424 -31.727 -11.758 1.00 95.34  ? 311 SER   A OG  1 
ATOM   2000 N  N   . SER   A 1 291 ? -23.868 -31.007 -14.013 1.00 90.27  ? 312 SER   A N   1 
ATOM   2001 C  CA  . SER   A 1 291 ? -24.175 -30.326 -15.267 1.00 90.76  ? 312 SER   A CA  1 
ATOM   2002 C  C   . SER   A 1 291 ? -23.087 -30.563 -16.310 1.00 91.68  ? 312 SER   A C   1 
ATOM   2003 O  O   . SER   A 1 291 ? -23.381 -30.875 -17.471 1.00 93.03  ? 312 SER   A O   1 
ATOM   2004 C  CB  . SER   A 1 291 ? -24.366 -28.830 -15.010 1.00 92.11  ? 312 SER   A CB  1 
ATOM   2005 O  OG  . SER   A 1 291 ? -24.722 -28.152 -16.203 1.00 91.09  ? 312 SER   A OG  1 
ATOM   2006 N  N   . VAL   A 1 292 ? -21.821 -30.426 -15.913 1.00 92.91  ? 313 VAL   A N   1 
ATOM   2007 C  CA  . VAL   A 1 292 ? -20.722 -30.632 -16.851 1.00 91.79  ? 313 VAL   A CA  1 
ATOM   2008 C  C   . VAL   A 1 292 ? -20.665 -32.087 -17.305 1.00 92.25  ? 313 VAL   A C   1 
ATOM   2009 O  O   . VAL   A 1 292 ? -20.438 -32.372 -18.487 1.00 93.90  ? 313 VAL   A O   1 
ATOM   2010 C  CB  . VAL   A 1 292 ? -19.390 -30.182 -16.225 1.00 90.55  ? 313 VAL   A CB  1 
ATOM   2011 C  CG1 . VAL   A 1 292 ? -18.245 -30.416 -17.199 1.00 91.72  ? 313 VAL   A CG1 1 
ATOM   2012 C  CG2 . VAL   A 1 292 ? -19.459 -28.718 -15.824 1.00 90.74  ? 313 VAL   A CG2 1 
ATOM   2013 N  N   . LEU   A 1 293 ? -20.867 -33.027 -16.377 1.00 91.38  ? 314 LEU   A N   1 
ATOM   2014 C  CA  . LEU   A 1 293 ? -20.837 -34.442 -16.736 1.00 91.03  ? 314 LEU   A CA  1 
ATOM   2015 C  C   . LEU   A 1 293 ? -21.906 -34.771 -17.770 1.00 92.61  ? 314 LEU   A C   1 
ATOM   2016 O  O   . LEU   A 1 293 ? -21.658 -35.540 -18.707 1.00 94.09  ? 314 LEU   A O   1 
ATOM   2017 C  CB  . LEU   A 1 293 ? -21.016 -35.305 -15.486 1.00 92.22  ? 314 LEU   A CB  1 
ATOM   2018 C  CG  . LEU   A 1 293 ? -19.787 -35.512 -14.599 1.00 89.87  ? 314 LEU   A CG  1 
ATOM   2019 C  CD1 . LEU   A 1 293 ? -20.168 -36.213 -13.304 1.00 91.85  ? 314 LEU   A CD1 1 
ATOM   2020 C  CD2 . LEU   A 1 293 ? -18.730 -36.306 -15.344 1.00 89.75  ? 314 LEU   A CD2 1 
ATOM   2021 N  N   . SER   A 1 294 ? -23.105 -34.204 -17.615 1.00 92.51  ? 315 SER   A N   1 
ATOM   2022 C  CA  . SER   A 1 294 ? -24.148 -34.400 -18.616 1.00 90.81  ? 315 SER   A CA  1 
ATOM   2023 C  C   . SER   A 1 294 ? -23.758 -33.768 -19.947 1.00 90.26  ? 315 SER   A C   1 
ATOM   2024 O  O   . SER   A 1 294 ? -24.027 -34.333 -21.013 1.00 92.87  ? 315 SER   A O   1 
ATOM   2025 C  CB  . SER   A 1 294 ? -25.474 -33.828 -18.114 1.00 91.72  ? 315 SER   A CB  1 
ATOM   2026 O  OG  . SER   A 1 294 ? -25.902 -34.493 -16.938 1.00 93.24  ? 315 SER   A OG  1 
ATOM   2027 N  N   . PHE   A 1 295 ? -23.127 -32.590 -19.903 1.00 89.53  ? 316 PHE   A N   1 
ATOM   2028 C  CA  . PHE   A 1 295 ? -22.643 -31.963 -21.129 1.00 88.88  ? 316 PHE   A CA  1 
ATOM   2029 C  C   . PHE   A 1 295 ? -21.597 -32.833 -21.815 1.00 89.44  ? 316 PHE   A C   1 
ATOM   2030 O  O   . PHE   A 1 295 ? -21.585 -32.948 -23.046 1.00 88.06  ? 316 PHE   A O   1 
ATOM   2031 C  CB  . PHE   A 1 295 ? -22.067 -30.579 -20.823 1.00 90.95  ? 316 PHE   A CB  1 
ATOM   2032 C  CG  . PHE   A 1 295 ? -23.098 -29.486 -20.770 1.00 89.78  ? 316 PHE   A CG  1 
ATOM   2033 C  CD1 . PHE   A 1 295 ? -23.894 -29.216 -21.870 1.00 91.93  ? 316 PHE   A CD1 1 
ATOM   2034 C  CD2 . PHE   A 1 295 ? -23.255 -28.714 -19.632 1.00 92.39  ? 316 PHE   A CD2 1 
ATOM   2035 C  CE1 . PHE   A 1 295 ? -24.838 -28.208 -21.830 1.00 95.27  ? 316 PHE   A CE1 1 
ATOM   2036 C  CE2 . PHE   A 1 295 ? -24.198 -27.703 -19.586 1.00 94.76  ? 316 PHE   A CE2 1 
ATOM   2037 C  CZ  . PHE   A 1 295 ? -24.989 -27.450 -20.688 1.00 94.78  ? 316 PHE   A CZ  1 
ATOM   2038 N  N   . ILE   A 1 296 ? -20.705 -33.447 -21.034 1.00 92.22  ? 317 ILE   A N   1 
ATOM   2039 C  CA  . ILE   A 1 296 ? -19.704 -34.344 -21.607 1.00 92.41  ? 317 ILE   A CA  1 
ATOM   2040 C  C   . ILE   A 1 296 ? -20.380 -35.541 -22.264 1.00 91.54  ? 317 ILE   A C   1 
ATOM   2041 O  O   . ILE   A 1 296 ? -20.040 -35.931 -23.387 1.00 90.54  ? 317 ILE   A O   1 
ATOM   2042 C  CB  . ILE   A 1 296 ? -18.700 -34.790 -20.527 1.00 91.56  ? 317 ILE   A CB  1 
ATOM   2043 C  CG1 . ILE   A 1 296 ? -17.879 -33.598 -20.027 1.00 89.98  ? 317 ILE   A CG1 1 
ATOM   2044 C  CG2 . ILE   A 1 296 ? -17.789 -35.890 -21.062 1.00 89.25  ? 317 ILE   A CG2 1 
ATOM   2045 C  CD1 . ILE   A 1 296 ? -16.890 -33.949 -18.934 1.00 89.55  ? 317 ILE   A CD1 1 
ATOM   2046 N  N   . MET   A 1 297 ? -21.360 -36.134 -21.577 1.00 92.42  ? 318 MET   A N   1 
ATOM   2047 C  CA  . MET   A 1 297 ? -21.978 -37.355 -22.083 1.00 94.44  ? 318 MET   A CA  1 
ATOM   2048 C  C   . MET   A 1 297 ? -22.828 -37.099 -23.321 1.00 93.28  ? 318 MET   A C   1 
ATOM   2049 O  O   . MET   A 1 297 ? -22.925 -37.973 -24.190 1.00 95.19  ? 318 MET   A O   1 
ATOM   2050 C  CB  . MET   A 1 297 ? -22.811 -38.023 -20.990 1.00 94.17  ? 318 MET   A CB  1 
ATOM   2051 C  CG  . MET   A 1 297 ? -21.977 -38.612 -19.867 1.00 97.38  ? 318 MET   A CG  1 
ATOM   2052 S  SD  . MET   A 1 297 ? -20.496 -39.441 -20.478 1.00 107.23 ? 318 MET   A SD  1 
ATOM   2053 C  CE  . MET   A 1 297 ? -21.208 -40.743 -21.480 1.00 100.18 ? 318 MET   A CE  1 
ATOM   2054 N  N   . TYR   A 1 298 ? -23.456 -35.925 -23.420 1.00 90.27  ? 319 TYR   A N   1 
ATOM   2055 C  CA  . TYR   A 1 298 ? -24.166 -35.585 -24.649 1.00 92.34  ? 319 TYR   A CA  1 
ATOM   2056 C  C   . TYR   A 1 298 ? -23.211 -35.546 -25.834 1.00 93.67  ? 319 TYR   A C   1 
ATOM   2057 O  O   . TYR   A 1 298 ? -23.533 -36.045 -26.919 1.00 94.69  ? 319 TYR   A O   1 
ATOM   2058 C  CB  . TYR   A 1 298 ? -24.886 -34.244 -24.498 1.00 95.34  ? 319 TYR   A CB  1 
ATOM   2059 C  CG  . TYR   A 1 298 ? -25.364 -33.668 -25.815 1.00 97.48  ? 319 TYR   A CG  1 
ATOM   2060 C  CD1 . TYR   A 1 298 ? -26.568 -34.073 -26.376 1.00 100.73 ? 319 TYR   A CD1 1 
ATOM   2061 C  CD2 . TYR   A 1 298 ? -24.608 -32.723 -26.499 1.00 96.73  ? 319 TYR   A CD2 1 
ATOM   2062 C  CE1 . TYR   A 1 298 ? -27.005 -33.554 -27.580 1.00 101.09 ? 319 TYR   A CE1 1 
ATOM   2063 C  CE2 . TYR   A 1 298 ? -25.036 -32.200 -27.704 1.00 96.97  ? 319 TYR   A CE2 1 
ATOM   2064 C  CZ  . TYR   A 1 298 ? -26.235 -32.619 -28.239 1.00 99.22  ? 319 TYR   A CZ  1 
ATOM   2065 O  OH  . TYR   A 1 298 ? -26.663 -32.096 -29.437 1.00 101.93 ? 319 TYR   A OH  1 
ATOM   2066 N  N   . GLU   A 1 299 ? -22.032 -34.948 -25.646 1.00 95.67  ? 320 GLU   A N   1 
ATOM   2067 C  CA  . GLU   A 1 299 ? -21.041 -34.912 -26.716 1.00 95.24  ? 320 GLU   A CA  1 
ATOM   2068 C  C   . GLU   A 1 299 ? -20.516 -36.307 -27.037 1.00 93.32  ? 320 GLU   A C   1 
ATOM   2069 O  O   . GLU   A 1 299 ? -20.320 -36.645 -28.210 1.00 91.84  ? 320 GLU   A O   1 
ATOM   2070 C  CB  . GLU   A 1 299 ? -19.893 -33.976 -26.336 1.00 90.94  ? 320 GLU   A CB  1 
ATOM   2071 C  CG  . GLU   A 1 299 ? -20.309 -32.522 -26.165 1.00 89.20  ? 320 GLU   A CG  1 
ATOM   2072 C  CD  . GLU   A 1 299 ? -20.882 -31.922 -27.437 1.00 91.06  ? 320 GLU   A CD  1 
ATOM   2073 O  OE1 . GLU   A 1 299 ? -20.550 -32.415 -28.535 1.00 92.75  ? 320 GLU   A OE1 1 
ATOM   2074 O  OE2 . GLU   A 1 299 ? -21.669 -30.957 -27.341 1.00 93.93  ? 320 GLU   A OE2 1 
ATOM   2075 N  N   . LEU   A 1 300 ? -20.279 -37.129 -26.012 1.00 90.37  ? 321 LEU   A N   1 
ATOM   2076 C  CA  . LEU   A 1 300 ? -19.802 -38.486 -26.257 1.00 92.65  ? 321 LEU   A CA  1 
ATOM   2077 C  C   . LEU   A 1 300 ? -20.859 -39.325 -26.967 1.00 98.17  ? 321 LEU   A C   1 
ATOM   2078 O  O   . LEU   A 1 300 ? -20.527 -40.167 -27.810 1.00 97.74  ? 321 LEU   A O   1 
ATOM   2079 C  CB  . LEU   A 1 300 ? -19.381 -39.145 -24.944 1.00 91.27  ? 321 LEU   A CB  1 
ATOM   2080 C  CG  . LEU   A 1 300 ? -18.137 -38.565 -24.268 1.00 90.48  ? 321 LEU   A CG  1 
ATOM   2081 C  CD1 . LEU   A 1 300 ? -17.731 -39.418 -23.077 1.00 90.32  ? 321 LEU   A CD1 1 
ATOM   2082 C  CD2 . LEU   A 1 300 ? -16.988 -38.438 -25.258 1.00 88.98  ? 321 LEU   A CD2 1 
ATOM   2083 N  N   . ALA   A 1 301 ? -22.135 -39.118 -26.633 1.00 96.63  ? 322 ALA   A N   1 
ATOM   2084 C  CA  . ALA   A 1 301 ? -23.202 -39.842 -27.316 1.00 98.15  ? 322 ALA   A CA  1 
ATOM   2085 C  C   . ALA   A 1 301 ? -23.321 -39.412 -28.774 1.00 98.40  ? 322 ALA   A C   1 
ATOM   2086 O  O   . ALA   A 1 301 ? -23.456 -40.256 -29.667 1.00 102.32 ? 322 ALA   A O   1 
ATOM   2087 C  CB  . ALA   A 1 301 ? -24.527 -39.637 -26.586 1.00 98.34  ? 322 ALA   A CB  1 
ATOM   2088 N  N   . THR   A 1 302 ? -23.271 -38.106 -29.035 1.00 95.52  ? 323 THR   A N   1 
ATOM   2089 C  CA  . THR   A 1 302 ? -23.379 -37.600 -30.397 1.00 95.36  ? 323 THR   A CA  1 
ATOM   2090 C  C   . THR   A 1 302 ? -22.095 -37.767 -31.198 1.00 96.93  ? 323 THR   A C   1 
ATOM   2091 O  O   . THR   A 1 302 ? -22.109 -37.534 -32.412 1.00 97.38  ? 323 THR   A O   1 
ATOM   2092 C  CB  . THR   A 1 302 ? -23.781 -36.123 -30.382 1.00 96.66  ? 323 THR   A CB  1 
ATOM   2093 O  OG1 . THR   A 1 302 ? -22.872 -35.386 -29.554 1.00 95.72  ? 323 THR   A OG1 1 
ATOM   2094 C  CG2 . THR   A 1 302 ? -25.194 -35.962 -29.844 1.00 98.87  ? 323 THR   A CG2 1 
ATOM   2095 N  N   . HIS   A 1 303 ? -20.992 -38.153 -30.558 1.00 96.67  ? 324 HIS   A N   1 
ATOM   2096 C  CA  . HIS   A 1 303 ? -19.713 -38.378 -31.231 1.00 94.10  ? 324 HIS   A CA  1 
ATOM   2097 C  C   . HIS   A 1 303 ? -19.155 -39.716 -30.761 1.00 95.98  ? 324 HIS   A C   1 
ATOM   2098 O  O   . HIS   A 1 303 ? -18.242 -39.763 -29.925 1.00 96.55  ? 324 HIS   A O   1 
ATOM   2099 C  CB  . HIS   A 1 303 ? -18.734 -37.235 -30.958 1.00 92.53  ? 324 HIS   A CB  1 
ATOM   2100 C  CG  . HIS   A 1 303 ? -19.272 -35.882 -31.308 1.00 92.65  ? 324 HIS   A CG  1 
ATOM   2101 N  ND1 . HIS   A 1 303 ? -20.268 -35.265 -30.582 1.00 92.83  ? 324 HIS   A ND1 1 
ATOM   2102 C  CD2 . HIS   A 1 303 ? -18.951 -35.025 -32.307 1.00 94.67  ? 324 HIS   A CD2 1 
ATOM   2103 C  CE1 . HIS   A 1 303 ? -20.538 -34.088 -31.119 1.00 93.48  ? 324 HIS   A CE1 1 
ATOM   2104 N  NE2 . HIS   A 1 303 ? -19.753 -33.919 -32.167 1.00 93.32  ? 324 HIS   A NE2 1 
ATOM   2105 N  N   . PRO   A 1 304 ? -19.688 -40.828 -31.276 1.00 97.46  ? 325 PRO   A N   1 
ATOM   2106 C  CA  . PRO   A 1 304 ? -19.227 -42.147 -30.806 1.00 97.03  ? 325 PRO   A CA  1 
ATOM   2107 C  C   . PRO   A 1 304 ? -17.749 -42.401 -31.046 1.00 95.88  ? 325 PRO   A C   1 
ATOM   2108 O  O   . PRO   A 1 304 ? -17.137 -43.176 -30.299 1.00 95.75  ? 325 PRO   A O   1 
ATOM   2109 C  CB  . PRO   A 1 304 ? -20.103 -43.126 -31.601 1.00 95.31  ? 325 PRO   A CB  1 
ATOM   2110 C  CG  . PRO   A 1 304 ? -21.300 -42.327 -32.010 1.00 95.47  ? 325 PRO   A CG  1 
ATOM   2111 C  CD  . PRO   A 1 304 ? -20.783 -40.943 -32.254 1.00 97.07  ? 325 PRO   A CD  1 
ATOM   2112 N  N   . ASP   A 1 305 ? -17.156 -41.780 -32.070 1.00 94.61  ? 326 ASP   A N   1 
ATOM   2113 C  CA  . ASP   A 1 305 ? -15.730 -41.970 -32.318 1.00 94.72  ? 326 ASP   A CA  1 
ATOM   2114 C  C   . ASP   A 1 305 ? -14.896 -41.456 -31.151 1.00 94.42  ? 326 ASP   A C   1 
ATOM   2115 O  O   . ASP   A 1 305 ? -13.915 -42.094 -30.751 1.00 92.83  ? 326 ASP   A O   1 
ATOM   2116 C  CB  . ASP   A 1 305 ? -15.326 -41.276 -33.619 1.00 93.43  ? 326 ASP   A CB  1 
ATOM   2117 C  CG  . ASP   A 1 305 ? -15.672 -39.801 -33.624 1.00 90.73  ? 326 ASP   A CG  1 
ATOM   2118 O  OD1 . ASP   A 1 305 ? -16.711 -39.433 -33.037 1.00 93.22  ? 326 ASP   A OD1 1 
ATOM   2119 O  OD2 . ASP   A 1 305 ? -14.903 -39.011 -34.211 1.00 92.82  ? 326 ASP   A OD2 1 
ATOM   2120 N  N   . VAL   A 1 306 ? -15.270 -40.302 -30.594 1.00 95.41  ? 327 VAL   A N   1 
ATOM   2121 C  CA  . VAL   A 1 306 ? -14.588 -39.787 -29.411 1.00 94.98  ? 327 VAL   A CA  1 
ATOM   2122 C  C   . VAL   A 1 306 ? -14.817 -40.711 -28.223 1.00 95.69  ? 327 VAL   A C   1 
ATOM   2123 O  O   . VAL   A 1 306 ? -13.898 -40.984 -27.440 1.00 94.80  ? 327 VAL   A O   1 
ATOM   2124 C  CB  . VAL   A 1 306 ? -15.053 -38.350 -29.111 1.00 94.48  ? 327 VAL   A CB  1 
ATOM   2125 C  CG1 . VAL   A 1 306 ? -14.348 -37.802 -27.879 1.00 97.21  ? 327 VAL   A CG1 1 
ATOM   2126 C  CG2 . VAL   A 1 306 ? -14.811 -37.454 -30.314 1.00 93.96  ? 327 VAL   A CG2 1 
ATOM   2127 N  N   . GLN   A 1 307 ? -16.049 -41.204 -28.066 1.00 93.35  ? 328 GLN   A N   1 
ATOM   2128 C  CA  . GLN   A 1 307 ? -16.352 -42.104 -26.959 1.00 94.25  ? 328 GLN   A CA  1 
ATOM   2129 C  C   . GLN   A 1 307 ? -15.555 -43.399 -27.064 1.00 98.10  ? 328 GLN   A C   1 
ATOM   2130 O  O   . GLN   A 1 307 ? -15.033 -43.896 -26.060 1.00 100.16 ? 328 GLN   A O   1 
ATOM   2131 C  CB  . GLN   A 1 307 ? -17.852 -42.392 -26.915 1.00 92.82  ? 328 GLN   A CB  1 
ATOM   2132 C  CG  . GLN   A 1 307 ? -18.288 -43.221 -25.719 1.00 92.48  ? 328 GLN   A CG  1 
ATOM   2133 C  CD  . GLN   A 1 307 ? -19.794 -43.368 -25.630 1.00 92.81  ? 328 GLN   A CD  1 
ATOM   2134 O  OE1 . GLN   A 1 307 ? -20.310 -44.051 -24.746 1.00 97.00  ? 328 GLN   A OE1 1 
ATOM   2135 N  NE2 . GLN   A 1 307 ? -20.508 -42.723 -26.545 1.00 90.15  ? 328 GLN   A NE2 1 
ATOM   2136 N  N   . GLN   A 1 308 ? -15.451 -43.963 -28.271 1.00 96.61  ? 329 GLN   A N   1 
ATOM   2137 C  CA  . GLN   A 1 308 ? -14.657 -45.176 -28.447 1.00 95.78  ? 329 GLN   A CA  1 
ATOM   2138 C  C   . GLN   A 1 308 ? -13.179 -44.915 -28.184 1.00 97.35  ? 329 GLN   A C   1 
ATOM   2139 O  O   . GLN   A 1 308 ? -12.517 -45.709 -27.505 1.00 98.02  ? 329 GLN   A O   1 
ATOM   2140 C  CB  . GLN   A 1 308 ? -14.854 -45.744 -29.852 1.00 99.57  ? 329 GLN   A CB  1 
ATOM   2141 C  CG  . GLN   A 1 308 ? -13.910 -46.896 -30.183 1.00 97.25  ? 329 GLN   A CG  1 
ATOM   2142 C  CD  . GLN   A 1 308 ? -14.216 -47.540 -31.521 1.00 94.76  ? 329 GLN   A CD  1 
ATOM   2143 O  OE1 . GLN   A 1 308 ? -15.344 -47.478 -32.008 1.00 92.02  ? 329 GLN   A OE1 1 
ATOM   2144 N  NE2 . GLN   A 1 308 ? -13.208 -48.161 -32.124 1.00 93.18  ? 329 GLN   A NE2 1 
ATOM   2145 N  N   . LYS   A 1 309 ? -12.645 -43.809 -28.709 1.00 97.00  ? 330 LYS   A N   1 
ATOM   2146 C  CA  . LYS   A 1 309 ? -11.242 -43.487 -28.473 1.00 94.46  ? 330 LYS   A CA  1 
ATOM   2147 C  C   . LYS   A 1 309 ? -10.980 -43.229 -26.994 1.00 97.57  ? 330 LYS   A C   1 
ATOM   2148 O  O   . LYS   A 1 309 ? -9.915  -43.579 -26.473 1.00 98.59  ? 330 LYS   A O   1 
ATOM   2149 C  CB  . LYS   A 1 309 ? -10.826 -42.281 -29.318 1.00 92.51  ? 330 LYS   A CB  1 
ATOM   2150 C  CG  . LYS   A 1 309 ? -9.410  -41.798 -29.044 1.00 91.95  ? 330 LYS   A CG  1 
ATOM   2151 C  CD  . LYS   A 1 309 ? -8.782  -41.143 -30.265 1.00 90.30  ? 330 LYS   A CD  1 
ATOM   2152 C  CE  . LYS   A 1 309 ? -7.351  -40.715 -29.970 1.00 86.34  ? 330 LYS   A CE  1 
ATOM   2153 N  NZ  . LYS   A 1 309 ? -6.620  -40.284 -31.193 1.00 92.28  ? 330 LYS   A NZ  1 
ATOM   2154 N  N   . LEU   A 1 310 ? -11.942 -42.616 -26.301 1.00 99.21  ? 331 LEU   A N   1 
ATOM   2155 C  CA  . LEU   A 1 310 ? -11.805 -42.428 -24.861 1.00 99.86  ? 331 LEU   A CA  1 
ATOM   2156 C  C   . LEU   A 1 310 ? -11.905 -43.755 -24.118 1.00 100.19 ? 331 LEU   A C   1 
ATOM   2157 O  O   . LEU   A 1 310 ? -11.154 -43.998 -23.165 1.00 101.86 ? 331 LEU   A O   1 
ATOM   2158 C  CB  . LEU   A 1 310 ? -12.860 -41.441 -24.360 1.00 99.76  ? 331 LEU   A CB  1 
ATOM   2159 C  CG  . LEU   A 1 310 ? -12.807 -41.058 -22.881 1.00 99.28  ? 331 LEU   A CG  1 
ATOM   2160 C  CD1 . LEU   A 1 310 ? -11.386 -40.717 -22.459 1.00 97.66  ? 331 LEU   A CD1 1 
ATOM   2161 C  CD2 . LEU   A 1 310 ? -13.736 -39.886 -22.612 1.00 94.03  ? 331 LEU   A CD2 1 
ATOM   2162 N  N   . GLN   A 1 311 ? -12.826 -44.628 -24.539 1.00 100.40 ? 332 GLN   A N   1 
ATOM   2163 C  CA  . GLN   A 1 311 ? -12.931 -45.948 -23.924 1.00 102.53 ? 332 GLN   A CA  1 
ATOM   2164 C  C   . GLN   A 1 311 ? -11.673 -46.771 -24.169 1.00 101.97 ? 332 GLN   A C   1 
ATOM   2165 O  O   . GLN   A 1 311 ? -11.230 -47.520 -23.290 1.00 101.86 ? 332 GLN   A O   1 
ATOM   2166 C  CB  . GLN   A 1 311 ? -14.165 -46.679 -24.455 1.00 100.54 ? 332 GLN   A CB  1 
ATOM   2167 C  CG  . GLN   A 1 311 ? -15.483 -46.191 -23.873 1.00 100.74 ? 332 GLN   A CG  1 
ATOM   2168 C  CD  . GLN   A 1 311 ? -16.683 -46.741 -24.617 1.00 102.54 ? 332 GLN   A CD  1 
ATOM   2169 O  OE1 . GLN   A 1 311 ? -16.638 -46.932 -25.833 1.00 103.14 ? 332 GLN   A OE1 1 
ATOM   2170 N  NE2 . GLN   A 1 311 ? -17.763 -47.003 -23.890 1.00 104.69 ? 332 GLN   A NE2 1 
ATOM   2171 N  N   . GLU   A 1 312 ? -11.086 -46.649 -25.362 1.00 100.12 ? 333 GLU   A N   1 
ATOM   2172 C  CA  . GLU   A 1 312 ? -9.849  -47.365 -25.654 1.00 102.61 ? 333 GLU   A CA  1 
ATOM   2173 C  C   . GLU   A 1 312 ? -8.704  -46.878 -24.773 1.00 103.69 ? 333 GLU   A C   1 
ATOM   2174 O  O   . GLU   A 1 312 ? -7.883  -47.679 -24.311 1.00 102.77 ? 333 GLU   A O   1 
ATOM   2175 C  CB  . GLU   A 1 312 ? -9.502  -47.219 -27.137 1.00 99.29  ? 333 GLU   A CB  1 
ATOM   2176 C  CG  . GLU   A 1 312 ? -10.413 -48.022 -28.056 1.00 97.25  ? 333 GLU   A CG  1 
ATOM   2177 C  CD  . GLU   A 1 312 ? -10.372 -47.545 -29.493 1.00 95.64  ? 333 GLU   A CD  1 
ATOM   2178 O  OE1 . GLU   A 1 312 ? -9.832  -46.447 -29.744 1.00 95.87  ? 333 GLU   A OE1 1 
ATOM   2179 O  OE2 . GLU   A 1 312 ? -10.885 -48.270 -30.372 1.00 97.97  ? 333 GLU   A OE2 1 
ATOM   2180 N  N   . GLU   A 1 313 ? -8.631  -45.566 -24.530 1.00 102.90 ? 334 GLU   A N   1 
ATOM   2181 C  CA  . GLU   A 1 313 ? -7.598  -45.036 -23.644 1.00 103.90 ? 334 GLU   A CA  1 
ATOM   2182 C  C   . GLU   A 1 313 ? -7.829  -45.462 -22.199 1.00 104.45 ? 334 GLU   A C   1 
ATOM   2183 O  O   . GLU   A 1 313 ? -6.877  -45.807 -21.489 1.00 104.88 ? 334 GLU   A O   1 
ATOM   2184 C  CB  . GLU   A 1 313 ? -7.542  -43.512 -23.747 1.00 102.67 ? 334 GLU   A CB  1 
ATOM   2185 C  CG  . GLU   A 1 313 ? -6.768  -42.846 -22.614 1.00 101.26 ? 334 GLU   A CG  1 
ATOM   2186 C  CD  . GLU   A 1 313 ? -6.566  -41.360 -22.835 1.00 100.79 ? 334 GLU   A CD  1 
ATOM   2187 O  OE1 . GLU   A 1 313 ? -5.792  -40.995 -23.744 1.00 100.31 ? 334 GLU   A OE1 1 
ATOM   2188 O  OE2 . GLU   A 1 313 ? -7.186  -40.558 -22.105 1.00 98.34  ? 334 GLU   A OE2 1 
ATOM   2189 N  N   . ILE   A 1 314 ? -9.085  -45.439 -21.746 1.00 103.73 ? 335 ILE   A N   1 
ATOM   2190 C  CA  . ILE   A 1 314 ? -9.383  -45.777 -20.357 1.00 105.28 ? 335 ILE   A CA  1 
ATOM   2191 C  C   . ILE   A 1 314 ? -9.030  -47.231 -20.073 1.00 108.16 ? 335 ILE   A C   1 
ATOM   2192 O  O   . ILE   A 1 314 ? -8.522  -47.564 -18.996 1.00 108.34 ? 335 ILE   A O   1 
ATOM   2193 C  CB  . ILE   A 1 314 ? -10.860 -45.480 -20.038 1.00 104.09 ? 335 ILE   A CB  1 
ATOM   2194 N  N   . ASP   A 1 315 ? -9.296  -48.121 -21.032 1.00 108.54 ? 336 ASP   A N   1 
ATOM   2195 C  CA  . ASP   A 1 315 ? -8.951  -49.526 -20.849 1.00 106.94 ? 336 ASP   A CA  1 
ATOM   2196 C  C   . ASP   A 1 315 ? -7.447  -49.756 -20.944 1.00 109.31 ? 336 ASP   A C   1 
ATOM   2197 O  O   . ASP   A 1 315 ? -6.923  -50.677 -20.308 1.00 111.01 ? 336 ASP   A O   1 
ATOM   2198 C  CB  . ASP   A 1 315 ? -9.687  -50.384 -21.877 1.00 103.00 ? 336 ASP   A CB  1 
ATOM   2199 C  CG  . ASP   A 1 315 ? -11.194 -50.277 -21.752 1.00 108.91 ? 336 ASP   A CG  1 
ATOM   2200 O  OD1 . ASP   A 1 315 ? -11.684 -50.062 -20.623 1.00 112.89 ? 336 ASP   A OD1 1 
ATOM   2201 O  OD2 . ASP   A 1 315 ? -11.889 -50.406 -22.782 1.00 110.77 ? 336 ASP   A OD2 1 
ATOM   2202 N  N   . ALA   A 1 316 ? -6.742  -48.941 -21.733 1.00 106.84 ? 337 ALA   A N   1 
ATOM   2203 C  CA  . ALA   A 1 316 ? -5.300  -49.116 -21.884 1.00 107.41 ? 337 ALA   A CA  1 
ATOM   2204 C  C   . ALA   A 1 316 ? -4.562  -48.766 -20.597 1.00 110.64 ? 337 ALA   A C   1 
ATOM   2205 O  O   . ALA   A 1 316 ? -3.706  -49.528 -20.133 1.00 112.76 ? 337 ALA   A O   1 
ATOM   2206 C  CB  . ALA   A 1 316 ? -4.789  -48.267 -23.047 1.00 107.83 ? 337 ALA   A CB  1 
ATOM   2207 N  N   . VAL   A 1 317 ? -4.877  -47.611 -20.008 1.00 109.53 ? 338 VAL   A N   1 
ATOM   2208 C  CA  . VAL   A 1 317 ? -4.224  -47.209 -18.767 1.00 109.55 ? 338 VAL   A CA  1 
ATOM   2209 C  C   . VAL   A 1 317 ? -4.657  -48.111 -17.618 1.00 110.90 ? 338 VAL   A C   1 
ATOM   2210 O  O   . VAL   A 1 317 ? -3.857  -48.445 -16.735 1.00 110.50 ? 338 VAL   A O   1 
ATOM   2211 C  CB  . VAL   A 1 317 ? -4.509  -45.726 -18.470 1.00 109.74 ? 338 VAL   A CB  1 
ATOM   2212 C  CG1 . VAL   A 1 317 ? -3.801  -45.290 -17.195 1.00 106.90 ? 338 VAL   A CG1 1 
ATOM   2213 C  CG2 . VAL   A 1 317 ? -4.078  -44.862 -19.645 1.00 106.14 ? 338 VAL   A CG2 1 
ATOM   2214 N  N   . LEU   A 1 318 ? -5.925  -48.527 -17.611 1.00 111.15 ? 339 LEU   A N   1 
ATOM   2215 C  CA  . LEU   A 1 318 ? -6.483  -49.378 -16.561 1.00 115.35 ? 339 LEU   A CA  1 
ATOM   2216 C  C   . LEU   A 1 318 ? -6.952  -50.682 -17.192 1.00 118.39 ? 339 LEU   A C   1 
ATOM   2217 O  O   . LEU   A 1 318 ? -8.114  -50.796 -17.614 1.00 119.11 ? 339 LEU   A O   1 
ATOM   2218 C  CB  . LEU   A 1 318 ? -7.630  -48.677 -15.841 1.00 115.58 ? 339 LEU   A CB  1 
ATOM   2219 C  CG  . LEU   A 1 318 ? -7.315  -47.341 -15.172 1.00 114.14 ? 339 LEU   A CG  1 
ATOM   2220 C  CD1 . LEU   A 1 318 ? -8.603  -46.714 -14.692 1.00 113.95 ? 339 LEU   A CD1 1 
ATOM   2221 C  CD2 . LEU   A 1 318 ? -6.344  -47.525 -14.017 1.00 111.96 ? 339 LEU   A CD2 1 
ATOM   2222 N  N   . PRO   A 1 319 ? -6.084  -51.686 -17.286 1.00 119.81 ? 340 PRO   A N   1 
ATOM   2223 C  CA  . PRO   A 1 319 ? -6.493  -52.958 -17.890 1.00 120.88 ? 340 PRO   A CA  1 
ATOM   2224 C  C   . PRO   A 1 319 ? -7.538  -53.676 -17.052 1.00 124.67 ? 340 PRO   A C   1 
ATOM   2225 O  O   . PRO   A 1 319 ? -7.543  -53.601 -15.820 1.00 124.56 ? 340 PRO   A O   1 
ATOM   2226 C  CB  . PRO   A 1 319 ? -5.187  -53.761 -17.950 1.00 119.74 ? 340 PRO   A CB  1 
ATOM   2227 C  CG  . PRO   A 1 319 ? -4.095  -52.738 -17.843 1.00 117.40 ? 340 PRO   A CG  1 
ATOM   2228 C  CD  . PRO   A 1 319 ? -4.650  -51.667 -16.956 1.00 119.52 ? 340 PRO   A CD  1 
ATOM   2229 N  N   . ASN   A 1 320 ? -8.426  -54.388 -17.749 1.00 127.63 ? 341 ASN   A N   1 
ATOM   2230 C  CA  . ASN   A 1 320 ? -9.465  -55.207 -17.122 1.00 129.15 ? 341 ASN   A CA  1 
ATOM   2231 C  C   . ASN   A 1 320 ? -10.321 -54.387 -16.159 1.00 126.53 ? 341 ASN   A C   1 
ATOM   2232 O  O   . ASN   A 1 320 ? -10.662 -54.837 -15.063 1.00 124.25 ? 341 ASN   A O   1 
ATOM   2233 C  CB  . ASN   A 1 320 ? -8.854  -56.415 -16.411 1.00 126.96 ? 341 ASN   A CB  1 
ATOM   2234 N  N   . LYS   A 1 321 ? -10.673 -53.171 -16.580 1.00 126.20 ? 342 LYS   A N   1 
ATOM   2235 C  CA  . LYS   A 1 321 ? -11.510 -52.266 -15.793 1.00 124.36 ? 342 LYS   A CA  1 
ATOM   2236 C  C   . LYS   A 1 321 ? -10.917 -52.036 -14.403 1.00 123.45 ? 342 LYS   A C   1 
ATOM   2237 O  O   . LYS   A 1 321 ? -11.599 -52.134 -13.380 1.00 124.09 ? 342 LYS   A O   1 
ATOM   2238 C  CB  . LYS   A 1 321 ? -12.945 -52.789 -15.701 1.00 120.37 ? 342 LYS   A CB  1 
ATOM   2239 N  N   . ALA   A 1 322 ? -9.622  -51.733 -14.377 1.00 122.51 ? 343 ALA   A N   1 
ATOM   2240 C  CA  . ALA   A 1 322 ? -8.930  -51.523 -13.118 1.00 120.84 ? 343 ALA   A CA  1 
ATOM   2241 C  C   . ALA   A 1 322 ? -9.466  -50.278 -12.412 1.00 118.27 ? 343 ALA   A C   1 
ATOM   2242 O  O   . ALA   A 1 322 ? -9.850  -49.301 -13.062 1.00 117.42 ? 343 ALA   A O   1 
ATOM   2243 C  CB  . ALA   A 1 322 ? -7.428  -51.380 -13.347 1.00 118.52 ? 343 ALA   A CB  1 
ATOM   2244 N  N   . PRO   A 1 323 ? -9.513  -50.294 -11.083 1.00 116.11 ? 344 PRO   A N   1 
ATOM   2245 C  CA  . PRO   A 1 323 ? -9.955  -49.112 -10.338 1.00 117.13 ? 344 PRO   A CA  1 
ATOM   2246 C  C   . PRO   A 1 323 ? -8.988  -47.958 -10.530 1.00 116.81 ? 344 PRO   A C   1 
ATOM   2247 O  O   . PRO   A 1 323 ? -7.780  -48.098 -10.283 1.00 116.26 ? 344 PRO   A O   1 
ATOM   2248 C  CB  . PRO   A 1 323 ? -9.967  -49.596 -8.879  1.00 114.94 ? 344 PRO   A CB  1 
ATOM   2249 C  CG  . PRO   A 1 323 ? -9.038  -50.763 -8.858  1.00 114.27 ? 344 PRO   A CG  1 
ATOM   2250 C  CD  . PRO   A 1 323 ? -9.186  -51.421 -10.195 1.00 115.97 ? 344 PRO   A CD  1 
ATOM   2251 N  N   . PRO   A 1 324 ? -9.478  -46.806 -10.981 1.00 116.20 ? 345 PRO   A N   1 
ATOM   2252 C  CA  . PRO   A 1 324 ? -8.590  -45.663 -11.212 1.00 113.67 ? 345 PRO   A CA  1 
ATOM   2253 C  C   . PRO   A 1 324 ? -8.048  -45.094 -9.912  1.00 112.34 ? 345 PRO   A C   1 
ATOM   2254 O  O   . PRO   A 1 324 ? -8.693  -45.146 -8.862  1.00 110.42 ? 345 PRO   A O   1 
ATOM   2255 C  CB  . PRO   A 1 324 ? -9.494  -44.651 -11.924 1.00 112.47 ? 345 PRO   A CB  1 
ATOM   2256 C  CG  . PRO   A 1 324 ? -10.870 -44.998 -11.463 1.00 113.83 ? 345 PRO   A CG  1 
ATOM   2257 C  CD  . PRO   A 1 324 ? -10.882 -46.489 -11.287 1.00 116.43 ? 345 PRO   A CD  1 
ATOM   2258 N  N   . THR   A 1 325 ? -6.843  -44.543 -9.997  1.00 110.53 ? 346 THR   A N   1 
ATOM   2259 C  CA  . THR   A 1 325 ? -6.196  -43.857 -8.888  1.00 111.55 ? 346 THR   A CA  1 
ATOM   2260 C  C   . THR   A 1 325 ? -5.831  -42.439 -9.316  1.00 109.64 ? 346 THR   A C   1 
ATOM   2261 O  O   . THR   A 1 325 ? -6.096  -42.017 -10.444 1.00 106.94 ? 346 THR   A O   1 
ATOM   2262 C  CB  . THR   A 1 325 ? -4.956  -44.623 -8.412  1.00 110.06 ? 346 THR   A CB  1 
ATOM   2263 O  OG1 . THR   A 1 325 ? -4.341  -43.914 -7.328  1.00 109.88 ? 346 THR   A OG1 1 
ATOM   2264 C  CG2 . THR   A 1 325 ? -3.953  -44.773 -9.542  1.00 106.52 ? 346 THR   A CG2 1 
ATOM   2265 N  N   . TYR   A 1 326 ? -5.209  -41.704 -8.392  1.00 108.74 ? 347 TYR   A N   1 
ATOM   2266 C  CA  . TYR   A 1 326 ? -4.835  -40.320 -8.667  1.00 106.75 ? 347 TYR   A CA  1 
ATOM   2267 C  C   . TYR   A 1 326 ? -3.851  -40.230 -9.828  1.00 106.34 ? 347 TYR   A C   1 
ATOM   2268 O  O   . TYR   A 1 326 ? -3.977  -39.354 -10.693 1.00 104.47 ? 347 TYR   A O   1 
ATOM   2269 C  CB  . TYR   A 1 326 ? -4.245  -39.692 -7.403  1.00 107.64 ? 347 TYR   A CB  1 
ATOM   2270 C  CG  . TYR   A 1 326 ? -3.861  -38.235 -7.527  1.00 106.71 ? 347 TYR   A CG  1 
ATOM   2271 C  CD1 . TYR   A 1 326 ? -4.772  -37.230 -7.229  1.00 106.19 ? 347 TYR   A CD1 1 
ATOM   2272 C  CD2 . TYR   A 1 326 ? -2.583  -37.864 -7.924  1.00 107.23 ? 347 TYR   A CD2 1 
ATOM   2273 C  CE1 . TYR   A 1 326 ? -4.424  -35.897 -7.334  1.00 106.19 ? 347 TYR   A CE1 1 
ATOM   2274 C  CE2 . TYR   A 1 326 ? -2.225  -36.533 -8.032  1.00 107.23 ? 347 TYR   A CE2 1 
ATOM   2275 C  CZ  . TYR   A 1 326 ? -3.150  -35.555 -7.736  1.00 107.71 ? 347 TYR   A CZ  1 
ATOM   2276 O  OH  . TYR   A 1 326 ? -2.801  -34.228 -7.841  1.00 107.68 ? 347 TYR   A OH  1 
ATOM   2277 N  N   . ASP   A 1 327 ? -2.866  -41.131 -9.868  1.00 106.94 ? 348 ASP   A N   1 
ATOM   2278 C  CA  . ASP   A 1 327 ? -1.825  -41.052 -10.889 1.00 105.94 ? 348 ASP   A CA  1 
ATOM   2279 C  C   . ASP   A 1 327 ? -2.339  -41.477 -12.261 1.00 105.23 ? 348 ASP   A C   1 
ATOM   2280 O  O   . ASP   A 1 327 ? -1.997  -40.856 -13.275 1.00 104.51 ? 348 ASP   A O   1 
ATOM   2281 C  CB  . ASP   A 1 327 ? -0.624  -41.903 -10.476 1.00 109.38 ? 348 ASP   A CB  1 
ATOM   2282 C  CG  . ASP   A 1 327 ? 0.384   -41.127 -9.649  1.00 112.45 ? 348 ASP   A CG  1 
ATOM   2283 O  OD1 . ASP   A 1 327 ? 0.922   -40.120 -10.159 1.00 114.03 ? 348 ASP   A OD1 1 
ATOM   2284 O  OD2 . ASP   A 1 327 ? 0.634   -41.518 -8.489  1.00 111.10 ? 348 ASP   A OD2 1 
ATOM   2285 N  N   . THR   A 1 328 ? -3.156  -42.533 -12.319 1.00 104.83 ? 349 THR   A N   1 
ATOM   2286 C  CA  . THR   A 1 328 ? -3.614  -43.039 -13.612 1.00 105.44 ? 349 THR   A CA  1 
ATOM   2287 C  C   . THR   A 1 328 ? -4.522  -42.044 -14.326 1.00 103.63 ? 349 THR   A C   1 
ATOM   2288 O  O   . THR   A 1 328 ? -4.495  -41.963 -15.559 1.00 103.81 ? 349 THR   A O   1 
ATOM   2289 C  CB  . THR   A 1 328 ? -4.337  -44.375 -13.437 1.00 109.40 ? 349 THR   A CB  1 
ATOM   2290 O  OG1 . THR   A 1 328 ? -5.346  -44.249 -12.426 1.00 111.88 ? 349 THR   A OG1 1 
ATOM   2291 C  CG2 . THR   A 1 328 ? -3.354  -45.469 -13.042 1.00 106.41 ? 349 THR   A CG2 1 
ATOM   2292 N  N   . VAL   A 1 329 ? -5.333  -41.292 -13.578 1.00 102.51 ? 350 VAL   A N   1 
ATOM   2293 C  CA  . VAL   A 1 329 ? -6.226  -40.315 -14.195 1.00 100.10 ? 350 VAL   A CA  1 
ATOM   2294 C  C   . VAL   A 1 329 ? -5.426  -39.230 -14.904 1.00 97.61  ? 350 VAL   A C   1 
ATOM   2295 O  O   . VAL   A 1 329 ? -5.743  -38.841 -16.035 1.00 97.52  ? 350 VAL   A O   1 
ATOM   2296 C  CB  . VAL   A 1 329 ? -7.176  -39.719 -13.140 1.00 100.18 ? 350 VAL   A CB  1 
ATOM   2297 C  CG1 . VAL   A 1 329 ? -8.027  -38.620 -13.751 1.00 96.40  ? 350 VAL   A CG1 1 
ATOM   2298 C  CG2 . VAL   A 1 329 ? -8.053  -40.802 -12.550 1.00 102.74 ? 350 VAL   A CG2 1 
ATOM   2299 N  N   . LEU   A 1 330 ? -4.376  -38.725 -14.253 1.00 96.73  ? 351 LEU   A N   1 
ATOM   2300 C  CA  . LEU   A 1 330 ? -3.569  -37.666 -14.847 1.00 97.89  ? 351 LEU   A CA  1 
ATOM   2301 C  C   . LEU   A 1 330 ? -2.795  -38.142 -16.069 1.00 100.44 ? 351 LEU   A C   1 
ATOM   2302 O  O   . LEU   A 1 330 ? -2.353  -37.311 -16.869 1.00 101.30 ? 351 LEU   A O   1 
ATOM   2303 C  CB  . LEU   A 1 330 ? -2.606  -37.094 -13.806 1.00 99.66  ? 351 LEU   A CB  1 
ATOM   2304 C  CG  . LEU   A 1 330 ? -3.245  -36.665 -12.482 1.00 100.01 ? 351 LEU   A CG  1 
ATOM   2305 C  CD1 . LEU   A 1 330 ? -2.212  -36.024 -11.569 1.00 101.82 ? 351 LEU   A CD1 1 
ATOM   2306 C  CD2 . LEU   A 1 330 ? -4.416  -35.724 -12.722 1.00 97.84  ? 351 LEU   A CD2 1 
ATOM   2307 N  N   . GLN   A 1 331 ? -2.613  -39.455 -16.228 1.00 99.94  ? 352 GLN   A N   1 
ATOM   2308 C  CA  . GLN   A 1 331 ? -1.950  -39.976 -17.417 1.00 97.98  ? 352 GLN   A CA  1 
ATOM   2309 C  C   . GLN   A 1 331 ? -2.866  -39.967 -18.634 1.00 95.55  ? 352 GLN   A C   1 
ATOM   2310 O  O   . GLN   A 1 331 ? -2.382  -39.892 -19.769 1.00 95.79  ? 352 GLN   A O   1 
ATOM   2311 C  CB  . GLN   A 1 331 ? -1.439  -41.394 -17.157 1.00 99.40  ? 352 GLN   A CB  1 
ATOM   2312 N  N   . MET   A 1 332 ? -4.178  -40.038 -18.423 1.00 96.84  ? 353 MET   A N   1 
ATOM   2313 C  CA  . MET   A 1 332 ? -5.145  -40.117 -19.517 1.00 95.66  ? 353 MET   A CA  1 
ATOM   2314 C  C   . MET   A 1 332 ? -5.258  -38.753 -20.185 1.00 94.83  ? 353 MET   A C   1 
ATOM   2315 O  O   . MET   A 1 332 ? -5.969  -37.868 -19.707 1.00 94.90  ? 353 MET   A O   1 
ATOM   2316 C  CB  . MET   A 1 332 ? -6.494  -40.592 -18.992 1.00 93.05  ? 353 MET   A CB  1 
ATOM   2317 C  CG  . MET   A 1 332 ? -6.438  -41.951 -18.321 1.00 97.82  ? 353 MET   A CG  1 
ATOM   2318 S  SD  . MET   A 1 332 ? -8.061  -42.547 -17.822 1.00 106.88 ? 353 MET   A SD  1 
ATOM   2319 C  CE  . MET   A 1 332 ? -7.606  -43.972 -16.840 1.00 106.74 ? 353 MET   A CE  1 
ATOM   2320 N  N   . GLU   A 1 333 ? -4.545  -38.580 -21.300 1.00 94.49  ? 354 GLU   A N   1 
ATOM   2321 C  CA  . GLU   A 1 333 ? -4.496  -37.276 -21.954 1.00 96.25  ? 354 GLU   A CA  1 
ATOM   2322 C  C   . GLU   A 1 333 ? -5.787  -36.973 -22.709 1.00 95.21  ? 354 GLU   A C   1 
ATOM   2323 O  O   . GLU   A 1 333 ? -6.278  -35.838 -22.674 1.00 94.48  ? 354 GLU   A O   1 
ATOM   2324 C  CB  . GLU   A 1 333 ? -3.293  -37.214 -22.895 1.00 97.40  ? 354 GLU   A CB  1 
ATOM   2325 C  CG  . GLU   A 1 333 ? -2.019  -37.770 -22.287 1.00 102.19 ? 354 GLU   A CG  1 
ATOM   2326 C  CD  . GLU   A 1 333 ? -0.866  -37.793 -23.268 1.00 113.93 ? 354 GLU   A CD  1 
ATOM   2327 O  OE1 . GLU   A 1 333 ? -0.713  -36.815 -24.030 1.00 113.87 ? 354 GLU   A OE1 1 
ATOM   2328 O  OE2 . GLU   A 1 333 ? -0.117  -38.793 -23.284 1.00 116.97 ? 354 GLU   A OE2 1 
ATOM   2329 N  N   . TYR   A 1 334 ? -6.347  -37.968 -23.404 1.00 94.70  ? 355 TYR   A N   1 
ATOM   2330 C  CA  . TYR   A 1 334 ? -7.561  -37.729 -24.181 1.00 94.89  ? 355 TYR   A CA  1 
ATOM   2331 C  C   . TYR   A 1 334 ? -8.747  -37.413 -23.280 1.00 92.46  ? 355 TYR   A C   1 
ATOM   2332 O  O   . TYR   A 1 334 ? -9.624  -36.630 -23.665 1.00 92.17  ? 355 TYR   A O   1 
ATOM   2333 C  CB  . TYR   A 1 334 ? -7.869  -38.938 -25.067 1.00 94.50  ? 355 TYR   A CB  1 
ATOM   2334 C  CG  . TYR   A 1 334 ? -8.825  -38.646 -26.205 1.00 90.69  ? 355 TYR   A CG  1 
ATOM   2335 C  CD1 . TYR   A 1 334 ? -8.439  -37.843 -27.271 1.00 86.96  ? 355 TYR   A CD1 1 
ATOM   2336 C  CD2 . TYR   A 1 334 ? -10.105 -39.185 -26.220 1.00 92.42  ? 355 TYR   A CD2 1 
ATOM   2337 C  CE1 . TYR   A 1 334 ? -9.305  -37.577 -28.316 1.00 87.68  ? 355 TYR   A CE1 1 
ATOM   2338 C  CE2 . TYR   A 1 334 ? -10.978 -38.925 -27.262 1.00 91.43  ? 355 TYR   A CE2 1 
ATOM   2339 C  CZ  . TYR   A 1 334 ? -10.573 -38.120 -28.307 1.00 91.86  ? 355 TYR   A CZ  1 
ATOM   2340 O  OH  . TYR   A 1 334 ? -11.438 -37.859 -29.345 1.00 92.36  ? 355 TYR   A OH  1 
ATOM   2341 N  N   . LEU   A 1 335 ? -8.793  -38.007 -22.085 1.00 92.82  ? 356 LEU   A N   1 
ATOM   2342 C  CA  . LEU   A 1 335 ? -9.829  -37.645 -21.125 1.00 90.94  ? 356 LEU   A CA  1 
ATOM   2343 C  C   . LEU   A 1 335 ? -9.729  -36.173 -20.749 1.00 88.34  ? 356 LEU   A C   1 
ATOM   2344 O  O   . LEU   A 1 335 ? -10.747 -35.481 -20.638 1.00 88.01  ? 356 LEU   A O   1 
ATOM   2345 C  CB  . LEU   A 1 335 ? -9.728  -38.530 -19.881 1.00 89.11  ? 356 LEU   A CB  1 
ATOM   2346 C  CG  . LEU   A 1 335 ? -10.720 -38.217 -18.759 1.00 85.96  ? 356 LEU   A CG  1 
ATOM   2347 C  CD1 . LEU   A 1 335 ? -12.146 -38.231 -19.288 1.00 90.66  ? 356 LEU   A CD1 1 
ATOM   2348 C  CD2 . LEU   A 1 335 ? -10.564 -39.197 -17.605 1.00 89.32  ? 356 LEU   A CD2 1 
ATOM   2349 N  N   . ASP   A 1 336 ? -8.505  -35.676 -20.555 1.00 89.40  ? 357 ASP   A N   1 
ATOM   2350 C  CA  . ASP   A 1 336 ? -8.310  -34.250 -20.320 1.00 89.61  ? 357 ASP   A CA  1 
ATOM   2351 C  C   . ASP   A 1 336 ? -8.769  -33.431 -21.520 1.00 89.74  ? 357 ASP   A C   1 
ATOM   2352 O  O   . ASP   A 1 336 ? -9.401  -32.380 -21.360 1.00 91.07  ? 357 ASP   A O   1 
ATOM   2353 C  CB  . ASP   A 1 336 ? -6.839  -33.972 -20.005 1.00 91.35  ? 357 ASP   A CB  1 
ATOM   2354 C  CG  . ASP   A 1 336 ? -6.592  -32.540 -19.568 1.00 91.31  ? 357 ASP   A CG  1 
ATOM   2355 O  OD1 . ASP   A 1 336 ? -7.070  -32.161 -18.478 1.00 90.00  ? 357 ASP   A OD1 1 
ATOM   2356 O  OD2 . ASP   A 1 336 ? -5.914  -31.796 -20.308 1.00 92.25  ? 357 ASP   A OD2 1 
ATOM   2357 N  N   . MET   A 1 337 ? -8.462  -33.902 -22.732 1.00 87.86  ? 358 MET   A N   1 
ATOM   2358 C  CA  . MET   A 1 337 ? -8.900  -33.209 -23.941 1.00 87.97  ? 358 MET   A CA  1 
ATOM   2359 C  C   . MET   A 1 337 ? -10.420 -33.174 -24.042 1.00 88.32  ? 358 MET   A C   1 
ATOM   2360 O  O   . MET   A 1 337 ? -11.002 -32.143 -24.400 1.00 87.54  ? 358 MET   A O   1 
ATOM   2361 C  CB  . MET   A 1 337 ? -8.300  -33.882 -25.176 1.00 92.20  ? 358 MET   A CB  1 
ATOM   2362 C  CG  . MET   A 1 337 ? -6.791  -33.752 -25.303 1.00 96.79  ? 358 MET   A CG  1 
ATOM   2363 S  SD  . MET   A 1 337 ? -6.103  -34.888 -26.527 1.00 93.26  ? 358 MET   A SD  1 
ATOM   2364 C  CE  . MET   A 1 337 ? -7.074  -34.472 -27.973 1.00 94.74  ? 358 MET   A CE  1 
ATOM   2365 N  N   . VAL   A 1 338 ? -11.080 -34.294 -23.736 1.00 91.67  ? 359 VAL   A N   1 
ATOM   2366 C  CA  . VAL   A 1 338 ? -12.539 -34.344 -23.807 1.00 90.04  ? 359 VAL   A CA  1 
ATOM   2367 C  C   . VAL   A 1 338 ? -13.156 -33.398 -22.784 1.00 88.78  ? 359 VAL   A C   1 
ATOM   2368 O  O   . VAL   A 1 338 ? -14.111 -32.671 -23.085 1.00 88.87  ? 359 VAL   A O   1 
ATOM   2369 C  CB  . VAL   A 1 338 ? -13.036 -35.790 -23.618 1.00 91.59  ? 359 VAL   A CB  1 
ATOM   2370 C  CG1 . VAL   A 1 338 ? -14.541 -35.816 -23.393 1.00 89.76  ? 359 VAL   A CG1 1 
ATOM   2371 C  CG2 . VAL   A 1 338 ? -12.665 -36.639 -24.825 1.00 92.48  ? 359 VAL   A CG2 1 
ATOM   2372 N  N   . VAL   A 1 339 ? -12.619 -33.391 -21.562 1.00 89.53  ? 360 VAL   A N   1 
ATOM   2373 C  CA  . VAL   A 1 339 ? -13.132 -32.498 -20.525 1.00 86.01  ? 360 VAL   A CA  1 
ATOM   2374 C  C   . VAL   A 1 339 ? -12.932 -31.042 -20.930 1.00 84.27  ? 360 VAL   A C   1 
ATOM   2375 O  O   . VAL   A 1 339 ? -13.848 -30.218 -20.823 1.00 82.74  ? 360 VAL   A O   1 
ATOM   2376 C  CB  . VAL   A 1 339 ? -12.461 -32.805 -19.174 1.00 86.41  ? 360 VAL   A CB  1 
ATOM   2377 C  CG1 . VAL   A 1 339 ? -12.802 -31.731 -18.152 1.00 88.30  ? 360 VAL   A CG1 1 
ATOM   2378 C  CG2 . VAL   A 1 339 ? -12.884 -34.175 -18.667 1.00 87.10  ? 360 VAL   A CG2 1 
ATOM   2379 N  N   . ASN   A 1 340 ? -11.732 -30.708 -21.412 1.00 84.17  ? 361 ASN   A N   1 
ATOM   2380 C  CA  . ASN   A 1 340 ? -11.423 -29.318 -21.732 1.00 83.71  ? 361 ASN   A CA  1 
ATOM   2381 C  C   . ASN   A 1 340 ? -12.286 -28.797 -22.876 1.00 82.75  ? 361 ASN   A C   1 
ATOM   2382 O  O   . ASN   A 1 340 ? -12.786 -27.668 -22.818 1.00 83.46  ? 361 ASN   A O   1 
ATOM   2383 C  CB  . ASN   A 1 340 ? -9.938  -29.171 -22.072 1.00 83.97  ? 361 ASN   A CB  1 
ATOM   2384 C  CG  . ASN   A 1 340 ? -9.041  -29.360 -20.863 1.00 86.16  ? 361 ASN   A CG  1 
ATOM   2385 O  OD1 . ASN   A 1 340 ? -9.503  -29.343 -19.722 1.00 87.76  ? 361 ASN   A OD1 1 
ATOM   2386 N  ND2 . ASN   A 1 340 ? -7.747  -29.533 -21.108 1.00 88.42  ? 361 ASN   A ND2 1 
ATOM   2387 N  N   . GLU   A 1 341 ? -12.473 -29.602 -23.925 1.00 83.92  ? 362 GLU   A N   1 
ATOM   2388 C  CA  . GLU   A 1 341 ? -13.267 -29.147 -25.063 1.00 86.72  ? 362 GLU   A CA  1 
ATOM   2389 C  C   . GLU   A 1 341 ? -14.725 -28.933 -24.674 1.00 86.54  ? 362 GLU   A C   1 
ATOM   2390 O  O   . GLU   A 1 341 ? -15.357 -27.970 -25.125 1.00 85.49  ? 362 GLU   A O   1 
ATOM   2391 C  CB  . GLU   A 1 341 ? -13.152 -30.139 -26.221 1.00 87.49  ? 362 GLU   A CB  1 
ATOM   2392 C  CG  . GLU   A 1 341 ? -14.079 -29.851 -27.403 1.00 88.30  ? 362 GLU   A CG  1 
ATOM   2393 C  CD  . GLU   A 1 341 ? -13.704 -28.599 -28.189 1.00 89.19  ? 362 GLU   A CD  1 
ATOM   2394 O  OE1 . GLU   A 1 341 ? -12.748 -27.892 -27.803 1.00 88.07  ? 362 GLU   A OE1 1 
ATOM   2395 O  OE2 . GLU   A 1 341 ? -14.371 -28.322 -29.208 1.00 89.69  ? 362 GLU   A OE2 1 
ATOM   2396 N  N   . THR   A 1 342 ? -15.277 -29.819 -23.841 1.00 86.18  ? 363 THR   A N   1 
ATOM   2397 C  CA  . THR   A 1 342 ? -16.645 -29.630 -23.371 1.00 87.26  ? 363 THR   A CA  1 
ATOM   2398 C  C   . THR   A 1 342 ? -16.768 -28.348 -22.557 1.00 84.76  ? 363 THR   A C   1 
ATOM   2399 O  O   . THR   A 1 342 ? -17.768 -27.627 -22.665 1.00 84.61  ? 363 THR   A O   1 
ATOM   2400 C  CB  . THR   A 1 342 ? -17.093 -30.835 -22.542 1.00 87.41  ? 363 THR   A CB  1 
ATOM   2401 O  OG1 . THR   A 1 342 ? -16.908 -32.037 -23.301 1.00 86.40  ? 363 THR   A OG1 1 
ATOM   2402 C  CG2 . THR   A 1 342 ? -18.564 -30.709 -22.166 1.00 86.37  ? 363 THR   A CG2 1 
ATOM   2403 N  N   . LEU   A 1 343 ? -15.756 -28.045 -21.740 1.00 83.48  ? 364 LEU   A N   1 
ATOM   2404 C  CA  . LEU   A 1 343 ? -15.769 -26.808 -20.967 1.00 81.26  ? 364 LEU   A CA  1 
ATOM   2405 C  C   . LEU   A 1 343 ? -15.687 -25.581 -21.865 1.00 82.75  ? 364 LEU   A C   1 
ATOM   2406 O  O   . LEU   A 1 343 ? -16.232 -24.527 -21.518 1.00 84.28  ? 364 LEU   A O   1 
ATOM   2407 C  CB  . LEU   A 1 343 ? -14.623 -26.806 -19.957 1.00 79.94  ? 364 LEU   A CB  1 
ATOM   2408 C  CG  . LEU   A 1 343 ? -14.734 -27.811 -18.810 1.00 76.46  ? 364 LEU   A CG  1 
ATOM   2409 C  CD1 . LEU   A 1 343 ? -13.468 -27.803 -17.974 1.00 75.87  ? 364 LEU   A CD1 1 
ATOM   2410 C  CD2 . LEU   A 1 343 ? -15.951 -27.512 -17.947 1.00 73.47  ? 364 LEU   A CD2 1 
ATOM   2411 N  N   . ARG   A 1 344 ? -15.010 -25.688 -23.011 1.00 84.31  ? 365 ARG   A N   1 
ATOM   2412 C  CA  . ARG   A 1 344 ? -14.982 -24.571 -23.949 1.00 85.55  ? 365 ARG   A CA  1 
ATOM   2413 C  C   . ARG   A 1 344 ? -16.361 -24.323 -24.545 1.00 87.18  ? 365 ARG   A C   1 
ATOM   2414 O  O   . ARG   A 1 344 ? -16.845 -23.186 -24.567 1.00 86.59  ? 365 ARG   A O   1 
ATOM   2415 C  CB  . ARG   A 1 344 ? -13.962 -24.830 -25.059 1.00 87.83  ? 365 ARG   A CB  1 
ATOM   2416 C  CG  . ARG   A 1 344 ? -13.814 -23.666 -26.032 1.00 88.04  ? 365 ARG   A CG  1 
ATOM   2417 C  CD  . ARG   A 1 344 ? -13.096 -24.081 -27.306 1.00 91.54  ? 365 ARG   A CD  1 
ATOM   2418 N  NE  . ARG   A 1 344 ? -13.881 -25.030 -28.088 1.00 95.52  ? 365 ARG   A NE  1 
ATOM   2419 C  CZ  . ARG   A 1 344 ? -14.743 -24.688 -29.036 1.00 95.16  ? 365 ARG   A CZ  1 
ATOM   2420 N  NH1 . ARG   A 1 344 ? -14.954 -23.422 -29.355 1.00 95.33  ? 365 ARG   A NH1 1 
ATOM   2421 N  NH2 . ARG   A 1 344 ? -15.409 -25.641 -29.682 1.00 94.43  ? 365 ARG   A NH2 1 
ATOM   2422 N  N   . LEU   A 1 345 ? -17.013 -25.381 -25.034 1.00 87.57  ? 366 LEU   A N   1 
ATOM   2423 C  CA  . LEU   A 1 345 ? -18.339 -25.223 -25.621 1.00 89.24  ? 366 LEU   A CA  1 
ATOM   2424 C  C   . LEU   A 1 345 ? -19.368 -24.788 -24.586 1.00 90.10  ? 366 LEU   A C   1 
ATOM   2425 O  O   . LEU   A 1 345 ? -20.297 -24.043 -24.915 1.00 94.25  ? 366 LEU   A O   1 
ATOM   2426 C  CB  . LEU   A 1 345 ? -18.779 -26.524 -26.291 1.00 89.94  ? 366 LEU   A CB  1 
ATOM   2427 C  CG  . LEU   A 1 345 ? -18.182 -26.811 -27.671 1.00 89.96  ? 366 LEU   A CG  1 
ATOM   2428 C  CD1 . LEU   A 1 345 ? -18.552 -28.208 -28.138 1.00 88.09  ? 366 LEU   A CD1 1 
ATOM   2429 C  CD2 . LEU   A 1 345 ? -18.647 -25.769 -28.677 1.00 89.32  ? 366 LEU   A CD2 1 
ATOM   2430 N  N   . PHE   A 1 346 ? -19.224 -25.236 -23.340 1.00 89.20  ? 367 PHE   A N   1 
ATOM   2431 C  CA  . PHE   A 1 346 ? -20.177 -24.929 -22.274 1.00 87.67  ? 367 PHE   A CA  1 
ATOM   2432 C  C   . PHE   A 1 346 ? -19.438 -24.414 -21.046 1.00 85.67  ? 367 PHE   A C   1 
ATOM   2433 O  O   . PHE   A 1 346 ? -19.282 -25.138 -20.053 1.00 83.07  ? 367 PHE   A O   1 
ATOM   2434 C  CB  . PHE   A 1 346 ? -21.019 -26.155 -21.917 1.00 89.32  ? 367 PHE   A CB  1 
ATOM   2435 C  CG  . PHE   A 1 346 ? -21.693 -26.795 -23.096 1.00 91.36  ? 367 PHE   A CG  1 
ATOM   2436 C  CD1 . PHE   A 1 346 ? -22.782 -26.192 -23.702 1.00 90.56  ? 367 PHE   A CD1 1 
ATOM   2437 C  CD2 . PHE   A 1 346 ? -21.242 -28.007 -23.593 1.00 92.29  ? 367 PHE   A CD2 1 
ATOM   2438 C  CE1 . PHE   A 1 346 ? -23.406 -26.783 -24.785 1.00 93.93  ? 367 PHE   A CE1 1 
ATOM   2439 C  CE2 . PHE   A 1 346 ? -21.862 -28.603 -24.674 1.00 90.39  ? 367 PHE   A CE2 1 
ATOM   2440 C  CZ  . PHE   A 1 346 ? -22.945 -27.990 -25.271 1.00 92.83  ? 367 PHE   A CZ  1 
ATOM   2441 N  N   . PRO   A 1 347 ? -18.972 -23.161 -21.072 1.00 82.99  ? 368 PRO   A N   1 
ATOM   2442 C  CA  . PRO   A 1 347 ? -18.444 -22.562 -19.840 1.00 80.73  ? 368 PRO   A CA  1 
ATOM   2443 C  C   . PRO   A 1 347 ? -19.578 -22.146 -18.917 1.00 80.28  ? 368 PRO   A C   1 
ATOM   2444 O  O   . PRO   A 1 347 ? -20.231 -21.123 -19.146 1.00 83.57  ? 368 PRO   A O   1 
ATOM   2445 C  CB  . PRO   A 1 347 ? -17.645 -21.358 -20.349 1.00 80.97  ? 368 PRO   A CB  1 
ATOM   2446 C  CG  . PRO   A 1 347 ? -18.329 -20.974 -21.619 1.00 83.40  ? 368 PRO   A CG  1 
ATOM   2447 C  CD  . PRO   A 1 347 ? -18.860 -22.249 -22.226 1.00 85.03  ? 368 PRO   A CD  1 
ATOM   2448 N  N   . ILE   A 1 348 ? -19.811 -22.930 -17.860 1.00 79.44  ? 369 ILE   A N   1 
ATOM   2449 C  CA  . ILE   A 1 348 ? -21.010 -22.758 -17.045 1.00 80.67  ? 369 ILE   A CA  1 
ATOM   2450 C  C   . ILE   A 1 348 ? -21.048 -21.408 -16.342 1.00 84.92  ? 369 ILE   A C   1 
ATOM   2451 O  O   . ILE   A 1 348 ? -22.136 -20.918 -16.015 1.00 87.18  ? 369 ILE   A O   1 
ATOM   2452 C  CB  . ILE   A 1 348 ? -21.134 -23.904 -16.024 1.00 80.06  ? 369 ILE   A CB  1 
ATOM   2453 C  CG1 . ILE   A 1 348 ? -19.859 -24.019 -15.193 1.00 76.15  ? 369 ILE   A CG1 1 
ATOM   2454 C  CG2 . ILE   A 1 348 ? -21.441 -25.221 -16.730 1.00 84.53  ? 369 ILE   A CG2 1 
ATOM   2455 C  CD1 . ILE   A 1 348 ? -19.932 -25.079 -14.129 1.00 79.27  ? 369 ILE   A CD1 1 
ATOM   2456 N  N   . ALA   A 1 349 ? -19.893 -20.791 -16.088 1.00 80.78  ? 370 ALA   A N   1 
ATOM   2457 C  CA  . ALA   A 1 349 ? -19.895 -19.444 -15.527 1.00 77.27  ? 370 ALA   A CA  1 
ATOM   2458 C  C   . ALA   A 1 349 ? -20.445 -18.433 -16.524 1.00 79.48  ? 370 ALA   A C   1 
ATOM   2459 O  O   . ALA   A 1 349 ? -21.152 -17.496 -16.138 1.00 86.24  ? 370 ALA   A O   1 
ATOM   2460 C  CB  . ALA   A 1 349 ? -18.486 -19.052 -15.090 1.00 78.93  ? 370 ALA   A CB  1 
ATOM   2461 N  N   . MET   A 1 350 ? -20.086 -18.586 -17.802 1.00 76.38  ? 371 MET   A N   1 
ATOM   2462 C  CA  . MET   A 1 350 ? -20.565 -17.769 -18.916 1.00 77.94  ? 371 MET   A CA  1 
ATOM   2463 C  C   . MET   A 1 350 ? -19.988 -16.359 -18.881 1.00 78.34  ? 371 MET   A C   1 
ATOM   2464 O  O   . MET   A 1 350 ? -20.101 -15.619 -19.863 1.00 78.32  ? 371 MET   A O   1 
ATOM   2465 C  CB  . MET   A 1 350 ? -22.096 -17.691 -18.928 1.00 79.87  ? 371 MET   A CB  1 
ATOM   2466 C  CG  . MET   A 1 350 ? -22.807 -19.025 -19.050 1.00 88.21  ? 371 MET   A CG  1 
ATOM   2467 S  SD  . MET   A 1 350 ? -24.599 -18.845 -18.946 1.00 103.23 ? 371 MET   A SD  1 
ATOM   2468 C  CE  . MET   A 1 350 ? -24.794 -18.317 -17.245 1.00 96.49  ? 371 MET   A CE  1 
ATOM   2469 N  N   . ARG   A 1 351 ? -19.325 -16.000 -17.783 1.00 79.15  ? 372 ARG   A N   1 
ATOM   2470 C  CA  . ARG   A 1 351 ? -18.891 -14.635 -17.515 1.00 74.14  ? 372 ARG   A CA  1 
ATOM   2471 C  C   . ARG   A 1 351 ? -17.922 -14.650 -16.343 1.00 71.89  ? 372 ARG   A C   1 
ATOM   2472 O  O   . ARG   A 1 351 ? -18.023 -15.496 -15.450 1.00 73.40  ? 372 ARG   A O   1 
ATOM   2473 C  CB  . ARG   A 1 351 ? -20.075 -13.713 -17.185 1.00 71.06  ? 372 ARG   A CB  1 
ATOM   2474 C  CG  . ARG   A 1 351 ? -20.785 -13.086 -18.372 1.00 72.28  ? 372 ARG   A CG  1 
ATOM   2475 C  CD  . ARG   A 1 351 ? -21.961 -12.249 -17.902 1.00 81.74  ? 372 ARG   A CD  1 
ATOM   2476 N  NE  . ARG   A 1 351 ? -22.707 -11.661 -19.009 1.00 80.79  ? 372 ARG   A NE  1 
ATOM   2477 C  CZ  . ARG   A 1 351 ? -23.685 -10.779 -18.862 1.00 82.65  ? 372 ARG   A CZ  1 
ATOM   2478 N  NH1 . ARG   A 1 351 ? -24.057 -10.354 -17.665 1.00 89.63  ? 372 ARG   A NH1 1 
ATOM   2479 N  NH2 . ARG   A 1 351 ? -24.302 -10.308 -19.941 1.00 82.85  ? 372 ARG   A NH2 1 
ATOM   2480 N  N   . LEU   A 1 352 ? -16.991 -13.700 -16.356 1.00 67.06  ? 373 LEU   A N   1 
ATOM   2481 C  CA  . LEU   A 1 352 ? -16.124 -13.420 -15.221 1.00 66.49  ? 373 LEU   A CA  1 
ATOM   2482 C  C   . LEU   A 1 352 ? -16.215 -11.932 -14.920 1.00 69.06  ? 373 LEU   A C   1 
ATOM   2483 O  O   . LEU   A 1 352 ? -16.134 -11.110 -15.838 1.00 68.60  ? 373 LEU   A O   1 
ATOM   2484 C  CB  . LEU   A 1 352 ? -14.672 -13.824 -15.506 1.00 70.40  ? 373 LEU   A CB  1 
ATOM   2485 C  CG  . LEU   A 1 352 ? -14.408 -15.265 -15.955 1.00 69.45  ? 373 LEU   A CG  1 
ATOM   2486 C  CD1 . LEU   A 1 352 ? -12.925 -15.482 -16.218 1.00 66.95  ? 373 LEU   A CD1 1 
ATOM   2487 C  CD2 . LEU   A 1 352 ? -14.921 -16.264 -14.931 1.00 67.96  ? 373 LEU   A CD2 1 
ATOM   2488 N  N   . GLU   A 1 353 ? -16.384 -11.584 -13.646 1.00 71.38  ? 374 GLU   A N   1 
ATOM   2489 C  CA  . GLU   A 1 353 ? -16.622 -10.201 -13.257 1.00 68.98  ? 374 GLU   A CA  1 
ATOM   2490 C  C   . GLU   A 1 353 ? -15.695 -9.784  -12.125 1.00 68.54  ? 374 GLU   A C   1 
ATOM   2491 O  O   . GLU   A 1 353 ? -15.412 -10.568 -11.214 1.00 68.57  ? 374 GLU   A O   1 
ATOM   2492 C  CB  . GLU   A 1 353 ? -18.082 -9.988  -12.836 1.00 71.79  ? 374 GLU   A CB  1 
ATOM   2493 C  CG  . GLU   A 1 353 ? -19.057 -10.024 -14.000 1.00 73.71  ? 374 GLU   A CG  1 
ATOM   2494 C  CD  . GLU   A 1 353 ? -20.482 -9.733  -13.582 1.00 79.01  ? 374 GLU   A CD  1 
ATOM   2495 O  OE1 . GLU   A 1 353 ? -20.696 -9.359  -12.408 1.00 80.45  ? 374 GLU   A OE1 1 
ATOM   2496 O  OE2 . GLU   A 1 353 ? -21.388 -9.879  -14.430 1.00 76.40  ? 374 GLU   A OE2 1 
ATOM   2497 N  N   . ARG   A 1 354 ? -15.223 -8.540  -12.202 1.00 67.98  ? 375 ARG   A N   1 
ATOM   2498 C  CA  . ARG   A 1 354 ? -14.440 -7.896  -11.157 1.00 66.51  ? 375 ARG   A CA  1 
ATOM   2499 C  C   . ARG   A 1 354 ? -14.916 -6.457  -11.020 1.00 65.88  ? 375 ARG   A C   1 
ATOM   2500 O  O   . ARG   A 1 354 ? -15.173 -5.788  -12.024 1.00 67.67  ? 375 ARG   A O   1 
ATOM   2501 C  CB  . ARG   A 1 354 ? -12.938 -7.915  -11.476 1.00 66.64  ? 375 ARG   A CB  1 
ATOM   2502 C  CG  . ARG   A 1 354 ? -12.323 -9.297  -11.644 1.00 68.87  ? 375 ARG   A CG  1 
ATOM   2503 C  CD  . ARG   A 1 354 ? -12.080 -9.971  -10.305 1.00 69.41  ? 375 ARG   A CD  1 
ATOM   2504 N  NE  . ARG   A 1 354 ? -11.396 -11.249 -10.463 1.00 68.61  ? 375 ARG   A NE  1 
ATOM   2505 C  CZ  . ARG   A 1 354 ? -12.011 -12.406 -10.669 1.00 67.70  ? 375 ARG   A CZ  1 
ATOM   2506 N  NH1 . ARG   A 1 354 ? -13.329 -12.484 -10.747 1.00 70.65  ? 375 ARG   A NH1 1 
ATOM   2507 N  NH2 . ARG   A 1 354 ? -11.284 -13.512 -10.801 1.00 70.83  ? 375 ARG   A NH2 1 
ATOM   2508 N  N   . VAL   A 1 355 ? -15.031 -5.981  -9.784  1.00 68.47  ? 376 VAL   A N   1 
ATOM   2509 C  CA  . VAL   A 1 355 ? -15.449 -4.607  -9.523  1.00 69.27  ? 376 VAL   A CA  1 
ATOM   2510 C  C   . VAL   A 1 355 ? -14.217 -3.714  -9.476  1.00 70.54  ? 376 VAL   A C   1 
ATOM   2511 O  O   . VAL   A 1 355 ? -13.253 -4.005  -8.757  1.00 69.88  ? 376 VAL   A O   1 
ATOM   2512 C  CB  . VAL   A 1 355 ? -16.251 -4.508  -8.215  1.00 64.73  ? 376 VAL   A CB  1 
ATOM   2513 C  CG1 . VAL   A 1 355 ? -16.532 -3.052  -7.877  1.00 62.97  ? 376 VAL   A CG1 1 
ATOM   2514 C  CG2 . VAL   A 1 355 ? -17.549 -5.276  -8.335  1.00 66.61  ? 376 VAL   A CG2 1 
ATOM   2515 N  N   . CYS   A 1 356 ? -14.247 -2.627  -10.244 1.00 70.92  ? 377 CYS   A N   1 
ATOM   2516 C  CA  . CYS   A 1 356 ? -13.149 -1.669  -10.269 1.00 73.40  ? 377 CYS   A CA  1 
ATOM   2517 C  C   . CYS   A 1 356 ? -13.216 -0.793  -9.022  1.00 74.67  ? 377 CYS   A C   1 
ATOM   2518 O  O   . CYS   A 1 356 ? -14.209 -0.092  -8.803  1.00 73.84  ? 377 CYS   A O   1 
ATOM   2519 C  CB  . CYS   A 1 356 ? -13.219 -0.821  -11.538 1.00 71.17  ? 377 CYS   A CB  1 
ATOM   2520 S  SG  . CYS   A 1 356 ? -11.799 0.260   -11.807 1.00 76.49  ? 377 CYS   A SG  1 
ATOM   2521 N  N   . LYS   A 1 357 ? -12.160 -0.832  -8.206  1.00 75.70  ? 378 LYS   A N   1 
ATOM   2522 C  CA  . LYS   A 1 357 ? -12.163 -0.152  -6.916  1.00 74.81  ? 378 LYS   A CA  1 
ATOM   2523 C  C   . LYS   A 1 357 ? -11.707 1.300   -6.981  1.00 77.68  ? 378 LYS   A C   1 
ATOM   2524 O  O   . LYS   A 1 357 ? -11.986 2.059   -6.046  1.00 81.71  ? 378 LYS   A O   1 
ATOM   2525 C  CB  . LYS   A 1 357 ? -11.272 -0.899  -5.917  1.00 75.59  ? 378 LYS   A CB  1 
ATOM   2526 C  CG  . LYS   A 1 357 ? -11.861 -2.194  -5.384  1.00 78.22  ? 378 LYS   A CG  1 
ATOM   2527 C  CD  . LYS   A 1 357 ? -11.010 -2.757  -4.250  1.00 77.90  ? 378 LYS   A CD  1 
ATOM   2528 C  CE  . LYS   A 1 357 ? -9.548  -2.886  -4.653  1.00 74.28  ? 378 LYS   A CE  1 
ATOM   2529 N  NZ  . LYS   A 1 357 ? -8.710  -3.476  -3.572  1.00 73.66  ? 378 LYS   A NZ  1 
ATOM   2530 N  N   . LYS   A 1 358 ? -11.015 1.709   -8.042  1.00 73.80  ? 379 LYS   A N   1 
ATOM   2531 C  CA  . LYS   A 1 358 ? -10.477 3.060   -8.113  1.00 77.92  ? 379 LYS   A CA  1 
ATOM   2532 C  C   . LYS   A 1 358 ? -10.302 3.462   -9.569  1.00 83.45  ? 379 LYS   A C   1 
ATOM   2533 O  O   . LYS   A 1 358 ? -10.343 2.625   -10.473 1.00 83.97  ? 379 LYS   A O   1 
ATOM   2534 C  CB  . LYS   A 1 358 ? -9.141  3.171   -7.367  1.00 78.87  ? 379 LYS   A CB  1 
ATOM   2535 N  N   . ASP   A 1 359 ? -10.120 4.764   -9.789  1.00 84.22  ? 380 ASP   A N   1 
ATOM   2536 C  CA  . ASP   A 1 359 ? -9.831  5.277   -11.125 1.00 80.59  ? 380 ASP   A CA  1 
ATOM   2537 C  C   . ASP   A 1 359 ? -8.478  4.744   -11.576 1.00 83.72  ? 380 ASP   A C   1 
ATOM   2538 O  O   . ASP   A 1 359 ? -7.441  5.103   -11.009 1.00 89.27  ? 380 ASP   A O   1 
ATOM   2539 C  CB  . ASP   A 1 359 ? -9.845  6.803   -11.131 1.00 87.46  ? 380 ASP   A CB  1 
ATOM   2540 C  CG  . ASP   A 1 359 ? -11.234 7.377   -10.931 1.00 90.55  ? 380 ASP   A CG  1 
ATOM   2541 O  OD1 . ASP   A 1 359 ? -12.117 6.650   -10.426 1.00 88.36  ? 380 ASP   A OD1 1 
ATOM   2542 O  OD2 . ASP   A 1 359 ? -11.446 8.556   -11.286 1.00 96.11  ? 380 ASP   A OD2 1 
ATOM   2543 N  N   . VAL   A 1 360 ? -8.482  3.877   -12.587 1.00 84.40  ? 381 VAL   A N   1 
ATOM   2544 C  CA  . VAL   A 1 360 ? -7.278  3.181   -13.026 1.00 86.11  ? 381 VAL   A CA  1 
ATOM   2545 C  C   . VAL   A 1 360 ? -7.218  3.197   -14.547 1.00 86.86  ? 381 VAL   A C   1 
ATOM   2546 O  O   . VAL   A 1 360 ? -8.234  3.005   -15.223 1.00 83.75  ? 381 VAL   A O   1 
ATOM   2547 C  CB  . VAL   A 1 360 ? -7.238  1.732   -12.493 1.00 84.22  ? 381 VAL   A CB  1 
ATOM   2548 C  CG1 . VAL   A 1 360 ? -5.978  1.022   -12.955 1.00 88.32  ? 381 VAL   A CG1 1 
ATOM   2549 C  CG2 . VAL   A 1 360 ? -7.318  1.720   -10.978 1.00 83.13  ? 381 VAL   A CG2 1 
ATOM   2550 N  N   . GLU   A 1 361 ? -6.023  3.438   -15.082 1.00 90.35  ? 382 GLU   A N   1 
ATOM   2551 C  CA  . GLU   A 1 361 ? -5.743  3.285   -16.503 1.00 89.22  ? 382 GLU   A CA  1 
ATOM   2552 C  C   . GLU   A 1 361 ? -5.017  1.962   -16.711 1.00 89.95  ? 382 GLU   A C   1 
ATOM   2553 O  O   . GLU   A 1 361 ? -3.937  1.749   -16.149 1.00 92.18  ? 382 GLU   A O   1 
ATOM   2554 C  CB  . GLU   A 1 361 ? -4.893  4.441   -17.030 1.00 94.26  ? 382 GLU   A CB  1 
ATOM   2555 C  CG  . GLU   A 1 361 ? -5.584  5.791   -17.042 1.00 97.62  ? 382 GLU   A CG  1 
ATOM   2556 C  CD  . GLU   A 1 361 ? -4.748  6.856   -17.725 1.00 101.05 ? 382 GLU   A CD  1 
ATOM   2557 O  OE1 . GLU   A 1 361 ? -3.667  6.514   -18.251 1.00 101.71 ? 382 GLU   A OE1 1 
ATOM   2558 O  OE2 . GLU   A 1 361 ? -5.169  8.032   -17.738 1.00 100.08 ? 382 GLU   A OE2 1 
ATOM   2559 N  N   . ILE   A 1 362 ? -5.608  1.078   -17.512 1.00 91.79  ? 383 ILE   A N   1 
ATOM   2560 C  CA  . ILE   A 1 362 ? -5.020  -0.222  -17.814 1.00 93.77  ? 383 ILE   A CA  1 
ATOM   2561 C  C   . ILE   A 1 362 ? -5.047  -0.434  -19.322 1.00 91.67  ? 383 ILE   A C   1 
ATOM   2562 O  O   . ILE   A 1 362 ? -6.085  -0.234  -19.964 1.00 92.36  ? 383 ILE   A O   1 
ATOM   2563 C  CB  . ILE   A 1 362 ? -5.751  -1.369  -17.085 1.00 92.17  ? 383 ILE   A CB  1 
ATOM   2564 C  CG1 . ILE   A 1 362 ? -7.261  -1.286  -17.304 1.00 88.67  ? 383 ILE   A CG1 1 
ATOM   2565 C  CG2 . ILE   A 1 362 ? -5.437  -1.346  -15.598 1.00 88.19  ? 383 ILE   A CG2 1 
ATOM   2566 C  CD1 . ILE   A 1 362 ? -7.808  -2.409  -18.143 1.00 85.26  ? 383 ILE   A CD1 1 
ATOM   2567 N  N   . ASN   A 1 363 ? -3.901  -0.829  -19.882 1.00 92.54  ? 384 ASN   A N   1 
ATOM   2568 C  CA  . ASN   A 1 363 ? -3.773  -1.148  -21.306 1.00 92.10  ? 384 ASN   A CA  1 
ATOM   2569 C  C   . ASN   A 1 363 ? -4.274  -0.005  -22.187 1.00 93.76  ? 384 ASN   A C   1 
ATOM   2570 O  O   . ASN   A 1 363 ? -4.960  -0.217  -23.190 1.00 93.50  ? 384 ASN   A O   1 
ATOM   2571 C  CB  . ASN   A 1 363 ? -4.496  -2.454  -21.642 1.00 91.18  ? 384 ASN   A CB  1 
ATOM   2572 C  CG  . ASN   A 1 363 ? -3.717  -3.680  -21.205 1.00 92.84  ? 384 ASN   A CG  1 
ATOM   2573 O  OD1 . ASN   A 1 363 ? -3.804  -4.110  -20.054 1.00 91.95  ? 384 ASN   A OD1 1 
ATOM   2574 N  ND2 . ASN   A 1 363 ? -2.947  -4.251  -22.125 1.00 94.74  ? 384 ASN   A ND2 1 
ATOM   2575 N  N   . GLY   A 1 364 ? -3.927  1.220   -21.807 1.00 94.45  ? 385 GLY   A N   1 
ATOM   2576 C  CA  . GLY   A 1 364 ? -4.347  2.386   -22.564 1.00 93.87  ? 385 GLY   A CA  1 
ATOM   2577 C  C   . GLY   A 1 364 ? -5.844  2.613   -22.588 1.00 98.73  ? 385 GLY   A C   1 
ATOM   2578 O  O   . GLY   A 1 364 ? -6.403  2.914   -23.650 1.00 102.48 ? 385 GLY   A O   1 
ATOM   2579 N  N   . MET   A 1 365 ? -6.511  2.464   -21.445 1.00 95.79  ? 386 MET   A N   1 
ATOM   2580 C  CA  . MET   A 1 365 ? -7.940  2.726   -21.353 1.00 91.46  ? 386 MET   A CA  1 
ATOM   2581 C  C   . MET   A 1 365 ? -8.277  3.087   -19.915 1.00 90.95  ? 386 MET   A C   1 
ATOM   2582 O  O   . MET   A 1 365 ? -7.793  2.444   -18.979 1.00 91.17  ? 386 MET   A O   1 
ATOM   2583 C  CB  . MET   A 1 365 ? -8.769  1.519   -21.807 1.00 89.41  ? 386 MET   A CB  1 
ATOM   2584 C  CG  . MET   A 1 365 ? -10.262 1.797   -21.902 1.00 89.68  ? 386 MET   A CG  1 
ATOM   2585 S  SD  . MET   A 1 365 ? -11.224 0.308   -22.219 1.00 93.06  ? 386 MET   A SD  1 
ATOM   2586 C  CE  . MET   A 1 365 ? -10.846 -0.634  -20.744 1.00 90.43  ? 386 MET   A CE  1 
ATOM   2587 N  N   . PHE   A 1 366 ? -9.115  4.106   -19.748 1.00 90.88  ? 387 PHE   A N   1 
ATOM   2588 C  CA  . PHE   A 1 366 ? -9.499  4.590   -18.428 1.00 88.27  ? 387 PHE   A CA  1 
ATOM   2589 C  C   . PHE   A 1 366 ? -10.786 3.904   -17.985 1.00 87.21  ? 387 PHE   A C   1 
ATOM   2590 O  O   . PHE   A 1 366 ? -11.810 3.992   -18.671 1.00 84.69  ? 387 PHE   A O   1 
ATOM   2591 C  CB  . PHE   A 1 366 ? -9.677  6.107   -18.445 1.00 86.44  ? 387 PHE   A CB  1 
ATOM   2592 C  CG  . PHE   A 1 366 ? -10.346 6.651   -17.216 1.00 87.84  ? 387 PHE   A CG  1 
ATOM   2593 C  CD1 . PHE   A 1 366 ? -9.630  6.831   -16.045 1.00 87.98  ? 387 PHE   A CD1 1 
ATOM   2594 C  CD2 . PHE   A 1 366 ? -11.691 6.982   -17.232 1.00 86.89  ? 387 PHE   A CD2 1 
ATOM   2595 C  CE1 . PHE   A 1 366 ? -10.242 7.331   -14.910 1.00 85.81  ? 387 PHE   A CE1 1 
ATOM   2596 C  CE2 . PHE   A 1 366 ? -12.308 7.481   -16.102 1.00 87.62  ? 387 PHE   A CE2 1 
ATOM   2597 C  CZ  . PHE   A 1 366 ? -11.583 7.656   -14.939 1.00 86.04  ? 387 PHE   A CZ  1 
ATOM   2598 N  N   . ILE   A 1 367 ? -10.732 3.231   -16.840 1.00 86.38  ? 388 ILE   A N   1 
ATOM   2599 C  CA  . ILE   A 1 367 ? -11.886 2.576   -16.236 1.00 79.81  ? 388 ILE   A CA  1 
ATOM   2600 C  C   . ILE   A 1 367 ? -12.222 3.327   -14.949 1.00 81.23  ? 388 ILE   A C   1 
ATOM   2601 O  O   . ILE   A 1 367 ? -11.424 3.314   -14.000 1.00 83.01  ? 388 ILE   A O   1 
ATOM   2602 C  CB  . ILE   A 1 367 ? -11.621 1.091   -15.958 1.00 78.99  ? 388 ILE   A CB  1 
ATOM   2603 C  CG1 . ILE   A 1 367 ? -11.252 0.365   -17.252 1.00 82.82  ? 388 ILE   A CG1 1 
ATOM   2604 C  CG2 . ILE   A 1 367 ? -12.838 0.445   -15.310 1.00 80.66  ? 388 ILE   A CG2 1 
ATOM   2605 C  CD1 . ILE   A 1 367 ? -11.027 -1.118  -17.073 1.00 77.90  ? 388 ILE   A CD1 1 
ATOM   2606 N  N   . PRO   A 1 368 ? -13.373 3.990   -14.865 1.00 81.86  ? 389 PRO   A N   1 
ATOM   2607 C  CA  . PRO   A 1 368 ? -13.708 4.741   -13.651 1.00 79.98  ? 389 PRO   A CA  1 
ATOM   2608 C  C   . PRO   A 1 368 ? -14.081 3.812   -12.504 1.00 78.65  ? 389 PRO   A C   1 
ATOM   2609 O  O   . PRO   A 1 368 ? -14.314 2.614   -12.672 1.00 78.24  ? 389 PRO   A O   1 
ATOM   2610 C  CB  . PRO   A 1 368 ? -14.893 5.609   -14.082 1.00 80.83  ? 389 PRO   A CB  1 
ATOM   2611 C  CG  . PRO   A 1 368 ? -15.508 4.868   -15.212 1.00 80.52  ? 389 PRO   A CG  1 
ATOM   2612 C  CD  . PRO   A 1 368 ? -14.389 4.153   -15.918 1.00 81.57  ? 389 PRO   A CD  1 
ATOM   2613 N  N   . LYS   A 1 369 ? -14.130 4.401   -11.312 1.00 78.76  ? 390 LYS   A N   1 
ATOM   2614 C  CA  . LYS   A 1 369 ? -14.396 3.648   -10.094 1.00 78.52  ? 390 LYS   A CA  1 
ATOM   2615 C  C   . LYS   A 1 369 ? -15.811 3.080   -10.095 1.00 77.70  ? 390 LYS   A C   1 
ATOM   2616 O  O   . LYS   A 1 369 ? -16.747 3.695   -10.614 1.00 79.05  ? 390 LYS   A O   1 
ATOM   2617 C  CB  . LYS   A 1 369 ? -14.188 4.548   -8.875  1.00 77.08  ? 390 LYS   A CB  1 
ATOM   2618 C  CG  . LYS   A 1 369 ? -14.314 3.853   -7.531  1.00 75.26  ? 390 LYS   A CG  1 
ATOM   2619 C  CD  . LYS   A 1 369 ? -14.308 4.876   -6.409  1.00 81.09  ? 390 LYS   A CD  1 
ATOM   2620 C  CE  . LYS   A 1 369 ? -14.243 4.215   -5.046  1.00 86.40  ? 390 LYS   A CE  1 
ATOM   2621 N  NZ  . LYS   A 1 369 ? -14.315 5.218   -3.947  1.00 88.41  ? 390 LYS   A NZ  1 
ATOM   2622 N  N   . GLY   A 1 370 ? -15.960 1.888   -9.517  1.00 73.95  ? 391 GLY   A N   1 
ATOM   2623 C  CA  . GLY   A 1 370 ? -17.256 1.271   -9.337  1.00 69.97  ? 391 GLY   A CA  1 
ATOM   2624 C  C   . GLY   A 1 370 ? -17.784 0.504   -10.527 1.00 73.48  ? 391 GLY   A C   1 
ATOM   2625 O  O   . GLY   A 1 370 ? -18.822 -0.159  -10.402 1.00 75.05  ? 391 GLY   A O   1 
ATOM   2626 N  N   . VAL   A 1 371 ? -17.112 0.558   -11.669 1.00 74.03  ? 392 VAL   A N   1 
ATOM   2627 C  CA  . VAL   A 1 371 ? -17.575 -0.137  -12.862 1.00 70.22  ? 392 VAL   A CA  1 
ATOM   2628 C  C   . VAL   A 1 371 ? -17.289 -1.625  -12.724 1.00 69.38  ? 392 VAL   A C   1 
ATOM   2629 O  O   . VAL   A 1 371 ? -16.240 -2.029  -12.208 1.00 71.54  ? 392 VAL   A O   1 
ATOM   2630 C  CB  . VAL   A 1 371 ? -16.908 0.452   -14.117 1.00 72.56  ? 392 VAL   A CB  1 
ATOM   2631 C  CG1 . VAL   A 1 371 ? -17.377 -0.272  -15.369 1.00 72.55  ? 392 VAL   A CG1 1 
ATOM   2632 C  CG2 . VAL   A 1 371 ? -17.208 1.934   -14.215 1.00 74.89  ? 392 VAL   A CG2 1 
ATOM   2633 N  N   . VAL   A 1 372 ? -18.233 -2.447  -13.172 1.00 70.88  ? 393 VAL   A N   1 
ATOM   2634 C  CA  . VAL   A 1 372 ? -18.059 -3.894  -13.199 1.00 70.25  ? 393 VAL   A CA  1 
ATOM   2635 C  C   . VAL   A 1 372 ? -17.384 -4.253  -14.517 1.00 67.92  ? 393 VAL   A C   1 
ATOM   2636 O  O   . VAL   A 1 372 ? -17.961 -4.068  -15.591 1.00 70.73  ? 393 VAL   A O   1 
ATOM   2637 C  CB  . VAL   A 1 372 ? -19.397 -4.627  -13.042 1.00 69.00  ? 393 VAL   A CB  1 
ATOM   2638 C  CG1 . VAL   A 1 372 ? -19.195 -6.130  -13.171 1.00 69.21  ? 393 VAL   A CG1 1 
ATOM   2639 C  CG2 . VAL   A 1 372 ? -20.038 -4.282  -11.708 1.00 64.29  ? 393 VAL   A CG2 1 
ATOM   2640 N  N   . VAL   A 1 373 ? -16.159 -4.760  -14.438 1.00 67.89  ? 394 VAL   A N   1 
ATOM   2641 C  CA  . VAL   A 1 373 ? -15.420 -5.196  -15.617 1.00 70.78  ? 394 VAL   A CA  1 
ATOM   2642 C  C   . VAL   A 1 373 ? -15.719 -6.673  -15.843 1.00 68.36  ? 394 VAL   A C   1 
ATOM   2643 O  O   . VAL   A 1 373 ? -15.486 -7.505  -14.959 1.00 67.86  ? 394 VAL   A O   1 
ATOM   2644 C  CB  . VAL   A 1 373 ? -13.912 -4.952  -15.451 1.00 68.75  ? 394 VAL   A CB  1 
ATOM   2645 C  CG1 . VAL   A 1 373 ? -13.170 -5.336  -16.718 1.00 69.67  ? 394 VAL   A CG1 1 
ATOM   2646 C  CG2 . VAL   A 1 373 ? -13.648 -3.496  -15.096 1.00 70.73  ? 394 VAL   A CG2 1 
ATOM   2647 N  N   . MET   A 1 374 ? -16.232 -7.001  -17.026 1.00 69.33  ? 395 MET   A N   1 
ATOM   2648 C  CA  . MET   A 1 374 ? -16.718 -8.339  -17.326 1.00 71.04  ? 395 MET   A CA  1 
ATOM   2649 C  C   . MET   A 1 374 ? -15.894 -8.966  -18.442 1.00 70.15  ? 395 MET   A C   1 
ATOM   2650 O  O   . MET   A 1 374 ? -15.572 -8.307  -19.435 1.00 72.97  ? 395 MET   A O   1 
ATOM   2651 C  CB  . MET   A 1 374 ? -18.201 -8.306  -17.722 1.00 70.51  ? 395 MET   A CB  1 
ATOM   2652 C  CG  . MET   A 1 374 ? -18.839 -9.678  -17.875 1.00 74.38  ? 395 MET   A CG  1 
ATOM   2653 S  SD  . MET   A 1 374 ? -19.056 -10.185 -19.592 1.00 74.83  ? 395 MET   A SD  1 
ATOM   2654 C  CE  . MET   A 1 374 ? -20.504 -9.234  -20.046 1.00 78.38  ? 395 MET   A CE  1 
ATOM   2655 N  N   . ILE   A 1 375 ? -15.553 -10.239 -18.271 1.00 66.29  ? 396 ILE   A N   1 
ATOM   2656 C  CA  . ILE   A 1 375 ? -14.875 -11.026 -19.293 1.00 71.03  ? 396 ILE   A CA  1 
ATOM   2657 C  C   . ILE   A 1 375 ? -15.884 -12.034 -19.840 1.00 73.29  ? 396 ILE   A C   1 
ATOM   2658 O  O   . ILE   A 1 375 ? -16.249 -12.989 -19.137 1.00 71.37  ? 396 ILE   A O   1 
ATOM   2659 C  CB  . ILE   A 1 375 ? -13.625 -11.729 -18.745 1.00 69.04  ? 396 ILE   A CB  1 
ATOM   2660 C  CG1 . ILE   A 1 375 ? -12.575 -10.705 -18.300 1.00 72.02  ? 396 ILE   A CG1 1 
ATOM   2661 C  CG2 . ILE   A 1 375 ? -13.042 -12.669 -19.792 1.00 67.52  ? 396 ILE   A CG2 1 
ATOM   2662 C  CD1 . ILE   A 1 375 ? -12.656 -10.322 -16.832 1.00 72.84  ? 396 ILE   A CD1 1 
ATOM   2663 N  N   . PRO   A 1 376 ? -16.364 -11.869 -21.074 1.00 71.96  ? 397 PRO   A N   1 
ATOM   2664 C  CA  . PRO   A 1 376 ? -17.365 -12.800 -21.611 1.00 71.81  ? 397 PRO   A CA  1 
ATOM   2665 C  C   . PRO   A 1 376 ? -16.764 -14.137 -22.009 1.00 75.44  ? 397 PRO   A C   1 
ATOM   2666 O  O   . PRO   A 1 376 ? -16.410 -14.340 -23.174 1.00 76.61  ? 397 PRO   A O   1 
ATOM   2667 C  CB  . PRO   A 1 376 ? -17.922 -12.049 -22.826 1.00 75.97  ? 397 PRO   A CB  1 
ATOM   2668 C  CG  . PRO   A 1 376 ? -16.797 -11.171 -23.262 1.00 75.02  ? 397 PRO   A CG  1 
ATOM   2669 C  CD  . PRO   A 1 376 ? -16.062 -10.772 -22.011 1.00 72.78  ? 397 PRO   A CD  1 
ATOM   2670 N  N   . SER   A 1 377 ? -16.643 -15.052 -21.043 1.00 76.58  ? 398 SER   A N   1 
ATOM   2671 C  CA  . SER   A 1 377 ? -16.026 -16.347 -21.315 1.00 76.13  ? 398 SER   A CA  1 
ATOM   2672 C  C   . SER   A 1 377 ? -16.751 -17.090 -22.431 1.00 80.79  ? 398 SER   A C   1 
ATOM   2673 O  O   . SER   A 1 377 ? -16.111 -17.692 -23.301 1.00 85.29  ? 398 SER   A O   1 
ATOM   2674 C  CB  . SER   A 1 377 ? -15.998 -17.194 -20.042 1.00 79.30  ? 398 SER   A CB  1 
ATOM   2675 O  OG  . SER   A 1 377 ? -15.221 -16.579 -19.029 1.00 80.61  ? 398 SER   A OG  1 
ATOM   2676 N  N   . TYR   A 1 378 ? -18.087 -17.064 -22.423 1.00 83.89  ? 399 TYR   A N   1 
ATOM   2677 C  CA  . TYR   A 1 378 ? -18.845 -17.764 -23.457 1.00 86.23  ? 399 TYR   A CA  1 
ATOM   2678 C  C   . TYR   A 1 378 ? -18.600 -17.157 -24.834 1.00 83.00  ? 399 TYR   A C   1 
ATOM   2679 O  O   . TYR   A 1 378 ? -18.410 -17.884 -25.817 1.00 84.99  ? 399 TYR   A O   1 
ATOM   2680 C  CB  . TYR   A 1 378 ? -20.337 -17.745 -23.120 1.00 85.44  ? 399 TYR   A CB  1 
ATOM   2681 C  CG  . TYR   A 1 378 ? -21.188 -18.571 -24.061 1.00 86.48  ? 399 TYR   A CG  1 
ATOM   2682 C  CD1 . TYR   A 1 378 ? -21.432 -19.914 -23.806 1.00 89.47  ? 399 TYR   A CD1 1 
ATOM   2683 C  CD2 . TYR   A 1 378 ? -21.746 -18.009 -25.202 1.00 86.60  ? 399 TYR   A CD2 1 
ATOM   2684 C  CE1 . TYR   A 1 378 ? -22.206 -20.675 -24.662 1.00 90.49  ? 399 TYR   A CE1 1 
ATOM   2685 C  CE2 . TYR   A 1 378 ? -22.521 -18.763 -26.066 1.00 91.14  ? 399 TYR   A CE2 1 
ATOM   2686 C  CZ  . TYR   A 1 378 ? -22.750 -20.095 -25.788 1.00 93.61  ? 399 TYR   A CZ  1 
ATOM   2687 O  OH  . TYR   A 1 378 ? -23.519 -20.855 -26.639 1.00 96.71  ? 399 TYR   A OH  1 
ATOM   2688 N  N   . ALA   A 1 379 ? -18.600 -15.825 -24.927 1.00 81.05  ? 400 ALA   A N   1 
ATOM   2689 C  CA  . ALA   A 1 379 ? -18.400 -15.177 -26.219 1.00 79.41  ? 400 ALA   A CA  1 
ATOM   2690 C  C   . ALA   A 1 379 ? -16.969 -15.335 -26.715 1.00 85.25  ? 400 ALA   A C   1 
ATOM   2691 O  O   . ALA   A 1 379 ? -16.729 -15.290 -27.927 1.00 88.62  ? 400 ALA   A O   1 
ATOM   2692 C  CB  . ALA   A 1 379 ? -18.771 -13.698 -26.132 1.00 80.76  ? 400 ALA   A CB  1 
ATOM   2693 N  N   . LEU   A 1 380 ? -16.009 -15.507 -25.802 1.00 85.17  ? 401 LEU   A N   1 
ATOM   2694 C  CA  . LEU   A 1 380 ? -14.629 -15.747 -26.212 1.00 81.27  ? 401 LEU   A CA  1 
ATOM   2695 C  C   . LEU   A 1 380 ? -14.407 -17.203 -26.603 1.00 83.52  ? 401 LEU   A C   1 
ATOM   2696 O  O   . LEU   A 1 380 ? -13.651 -17.489 -27.538 1.00 89.83  ? 401 LEU   A O   1 
ATOM   2697 C  CB  . LEU   A 1 380 ? -13.668 -15.346 -25.093 1.00 78.27  ? 401 LEU   A CB  1 
ATOM   2698 C  CG  . LEU   A 1 380 ? -13.633 -13.863 -24.717 1.00 80.18  ? 401 LEU   A CG  1 
ATOM   2699 C  CD1 . LEU   A 1 380 ? -12.699 -13.624 -23.540 1.00 75.54  ? 401 LEU   A CD1 1 
ATOM   2700 C  CD2 . LEU   A 1 380 ? -13.229 -13.013 -25.913 1.00 79.66  ? 401 LEU   A CD2 1 
ATOM   2701 N  N   . HIS   A 1 381 ? -15.057 -18.134 -25.900 1.00 82.90  ? 402 HIS   A N   1 
ATOM   2702 C  CA  . HIS   A 1 381 ? -14.896 -19.552 -26.198 1.00 84.46  ? 402 HIS   A CA  1 
ATOM   2703 C  C   . HIS   A 1 381 ? -15.428 -19.924 -27.576 1.00 88.20  ? 402 HIS   A C   1 
ATOM   2704 O  O   . HIS   A 1 381 ? -15.005 -20.941 -28.135 1.00 90.52  ? 402 HIS   A O   1 
ATOM   2705 C  CB  . HIS   A 1 381 ? -15.596 -20.396 -25.134 1.00 83.10  ? 402 HIS   A CB  1 
ATOM   2706 C  CG  . HIS   A 1 381 ? -14.867 -20.457 -23.828 1.00 81.45  ? 402 HIS   A CG  1 
ATOM   2707 N  ND1 . HIS   A 1 381 ? -15.188 -21.362 -22.840 1.00 79.41  ? 402 HIS   A ND1 1 
ATOM   2708 C  CD2 . HIS   A 1 381 ? -13.832 -19.727 -23.347 1.00 79.05  ? 402 HIS   A CD2 1 
ATOM   2709 C  CE1 . HIS   A 1 381 ? -14.384 -21.188 -21.806 1.00 78.26  ? 402 HIS   A CE1 1 
ATOM   2710 N  NE2 . HIS   A 1 381 ? -13.552 -20.201 -22.089 1.00 78.54  ? 402 HIS   A NE2 1 
ATOM   2711 N  N   . ARG   A 1 382 ? -16.348 -19.135 -28.129 1.00 88.92  ? 403 ARG   A N   1 
ATOM   2712 C  CA  . ARG   A 1 382 ? -16.923 -19.404 -29.440 1.00 92.19  ? 403 ARG   A CA  1 
ATOM   2713 C  C   . ARG   A 1 382 ? -16.568 -18.333 -30.462 1.00 94.34  ? 403 ARG   A C   1 
ATOM   2714 O  O   . ARG   A 1 382 ? -17.174 -18.289 -31.538 1.00 95.26  ? 403 ARG   A O   1 
ATOM   2715 C  CB  . ARG   A 1 382 ? -18.442 -19.547 -29.328 1.00 92.42  ? 403 ARG   A CB  1 
ATOM   2716 C  CG  . ARG   A 1 382 ? -18.878 -20.758 -28.522 1.00 91.33  ? 403 ARG   A CG  1 
ATOM   2717 C  CD  . ARG   A 1 382 ? -20.361 -20.713 -28.201 1.00 94.98  ? 403 ARG   A CD  1 
ATOM   2718 N  NE  . ARG   A 1 382 ? -20.772 -21.856 -27.394 1.00 98.00  ? 403 ARG   A NE  1 
ATOM   2719 C  CZ  . ARG   A 1 382 ? -21.361 -22.942 -27.875 1.00 96.18  ? 403 ARG   A CZ  1 
ATOM   2720 N  NH1 . ARG   A 1 382 ? -21.648 -23.060 -29.161 1.00 98.87  ? 403 ARG   A NH1 1 
ATOM   2721 N  NH2 . ARG   A 1 382 ? -21.671 -23.934 -27.045 1.00 95.38  ? 403 ARG   A NH2 1 
ATOM   2722 N  N   . ASP   A 1 383 ? -15.609 -17.475 -30.151 1.00 95.75  ? 404 ASP   A N   1 
ATOM   2723 C  CA  . ASP   A 1 383 ? -15.159 -16.462 -31.095 1.00 97.66  ? 404 ASP   A CA  1 
ATOM   2724 C  C   . ASP   A 1 383 ? -14.370 -17.128 -32.214 1.00 101.26 ? 404 ASP   A C   1 
ATOM   2725 O  O   . ASP   A 1 383 ? -13.358 -17.787 -31.937 1.00 100.34 ? 404 ASP   A O   1 
ATOM   2726 C  CB  . ASP   A 1 383 ? -14.304 -15.425 -30.371 1.00 93.92  ? 404 ASP   A CB  1 
ATOM   2727 C  CG  . ASP   A 1 383 ? -13.975 -14.226 -31.237 1.00 97.53  ? 404 ASP   A CG  1 
ATOM   2728 O  OD1 . ASP   A 1 383 ? -14.540 -14.106 -32.344 1.00 98.39  ? 404 ASP   A OD1 1 
ATOM   2729 O  OD2 . ASP   A 1 383 ? -13.145 -13.400 -30.804 1.00 100.09 ? 404 ASP   A OD2 1 
ATOM   2730 N  N   . PRO   A 1 384 ? -14.787 -16.997 -33.476 1.00 102.88 ? 405 PRO   A N   1 
ATOM   2731 C  CA  . PRO   A 1 384 ? -14.037 -17.640 -34.568 1.00 103.10 ? 405 PRO   A CA  1 
ATOM   2732 C  C   . PRO   A 1 384 ? -12.617 -17.126 -34.723 1.00 102.34 ? 405 PRO   A C   1 
ATOM   2733 O  O   . PRO   A 1 384 ? -11.790 -17.818 -35.329 1.00 104.36 ? 405 PRO   A O   1 
ATOM   2734 C  CB  . PRO   A 1 384 ? -14.885 -17.325 -35.809 1.00 100.77 ? 405 PRO   A CB  1 
ATOM   2735 C  CG  . PRO   A 1 384 ? -16.260 -17.082 -35.273 1.00 100.75 ? 405 PRO   A CG  1 
ATOM   2736 C  CD  . PRO   A 1 384 ? -16.056 -16.415 -33.945 1.00 99.40  ? 405 PRO   A CD  1 
ATOM   2737 N  N   . LYS   A 1 385 ? -12.307 -15.936 -34.200 1.00 102.15 ? 406 LYS   A N   1 
ATOM   2738 C  CA  . LYS   A 1 385 ? -10.955 -15.402 -34.327 1.00 102.22 ? 406 LYS   A CA  1 
ATOM   2739 C  C   . LYS   A 1 385 ? -9.931  -16.290 -33.631 1.00 102.05 ? 406 LYS   A C   1 
ATOM   2740 O  O   . LYS   A 1 385 ? -8.774  -16.360 -34.063 1.00 108.28 ? 406 LYS   A O   1 
ATOM   2741 C  CB  . LYS   A 1 385 ? -10.895 -13.983 -33.761 1.00 101.85 ? 406 LYS   A CB  1 
ATOM   2742 C  CG  . LYS   A 1 385 ? -9.549  -13.304 -33.946 1.00 102.68 ? 406 LYS   A CG  1 
ATOM   2743 C  CD  . LYS   A 1 385 ? -9.384  -12.117 -33.017 1.00 99.00  ? 406 LYS   A CD  1 
ATOM   2744 C  CE  . LYS   A 1 385 ? -7.971  -11.564 -33.098 1.00 97.76  ? 406 LYS   A CE  1 
ATOM   2745 N  NZ  . LYS   A 1 385 ? -6.952  -12.633 -32.899 1.00 98.75  ? 406 LYS   A NZ  1 
ATOM   2746 N  N   . TYR   A 1 386 ? -10.334 -16.981 -32.563 1.00 98.51  ? 407 TYR   A N   1 
ATOM   2747 C  CA  . TYR   A 1 386 ? -9.426  -17.819 -31.795 1.00 97.54  ? 407 TYR   A CA  1 
ATOM   2748 C  C   . TYR   A 1 386 ? -9.695  -19.308 -31.944 1.00 98.30  ? 407 TYR   A C   1 
ATOM   2749 O  O   . TYR   A 1 386 ? -8.850  -20.114 -31.536 1.00 95.51  ? 407 TYR   A O   1 
ATOM   2750 C  CB  . TYR   A 1 386 ? -9.491  -17.446 -30.306 1.00 95.43  ? 407 TYR   A CB  1 
ATOM   2751 C  CG  . TYR   A 1 386 ? -9.087  -16.020 -30.011 1.00 93.90  ? 407 TYR   A CG  1 
ATOM   2752 C  CD1 . TYR   A 1 386 ? -7.762  -15.693 -29.757 1.00 94.37  ? 407 TYR   A CD1 1 
ATOM   2753 C  CD2 . TYR   A 1 386 ? -10.031 -15.002 -29.986 1.00 95.38  ? 407 TYR   A CD2 1 
ATOM   2754 C  CE1 . TYR   A 1 386 ? -7.387  -14.391 -29.487 1.00 94.61  ? 407 TYR   A CE1 1 
ATOM   2755 C  CE2 . TYR   A 1 386 ? -9.666  -13.697 -29.718 1.00 98.77  ? 407 TYR   A CE2 1 
ATOM   2756 C  CZ  . TYR   A 1 386 ? -8.342  -13.397 -29.469 1.00 98.80  ? 407 TYR   A CZ  1 
ATOM   2757 O  OH  . TYR   A 1 386 ? -7.970  -12.100 -29.201 1.00 95.30  ? 407 TYR   A OH  1 
ATOM   2758 N  N   . TRP   A 1 387 ? -10.835 -19.699 -32.512 1.00 101.19 ? 408 TRP   A N   1 
ATOM   2759 C  CA  . TRP   A 1 387 ? -11.215 -21.101 -32.613 1.00 102.44 ? 408 TRP   A CA  1 
ATOM   2760 C  C   . TRP   A 1 387 ? -11.708 -21.401 -34.020 1.00 104.35 ? 408 TRP   A C   1 
ATOM   2761 O  O   . TRP   A 1 387 ? -12.572 -20.690 -34.545 1.00 101.92 ? 408 TRP   A O   1 
ATOM   2762 C  CB  . TRP   A 1 387 ? -12.294 -21.450 -31.582 1.00 100.15 ? 408 TRP   A CB  1 
ATOM   2763 C  CG  . TRP   A 1 387 ? -11.918 -21.049 -30.191 1.00 95.49  ? 408 TRP   A CG  1 
ATOM   2764 C  CD1 . TRP   A 1 387 ? -12.290 -19.910 -29.538 1.00 92.57  ? 408 TRP   A CD1 1 
ATOM   2765 C  CD2 . TRP   A 1 387 ? -11.079 -21.775 -29.286 1.00 92.37  ? 408 TRP   A CD2 1 
ATOM   2766 N  NE1 . TRP   A 1 387 ? -11.741 -19.886 -28.279 1.00 91.40  ? 408 TRP   A NE1 1 
ATOM   2767 C  CE2 . TRP   A 1 387 ? -10.993 -21.020 -28.100 1.00 93.81  ? 408 TRP   A CE2 1 
ATOM   2768 C  CE3 . TRP   A 1 387 ? -10.396 -22.993 -29.362 1.00 90.89  ? 408 TRP   A CE3 1 
ATOM   2769 C  CZ2 . TRP   A 1 387 ? -10.251 -21.442 -26.999 1.00 91.02  ? 408 TRP   A CZ2 1 
ATOM   2770 C  CZ3 . TRP   A 1 387 ? -9.660  -23.410 -28.268 1.00 88.74  ? 408 TRP   A CZ3 1 
ATOM   2771 C  CH2 . TRP   A 1 387 ? -9.594  -22.637 -27.103 1.00 90.19  ? 408 TRP   A CH2 1 
ATOM   2772 N  N   . THR   A 1 388 ? -11.162 -22.456 -34.622 1.00 107.39 ? 409 THR   A N   1 
ATOM   2773 C  CA  . THR   A 1 388 ? -11.564 -22.881 -35.958 1.00 107.46 ? 409 THR   A CA  1 
ATOM   2774 C  C   . THR   A 1 388 ? -12.838 -23.711 -35.865 1.00 104.18 ? 409 THR   A C   1 
ATOM   2775 O  O   . THR   A 1 388 ? -12.868 -24.734 -35.170 1.00 102.52 ? 409 THR   A O   1 
ATOM   2776 C  CB  . THR   A 1 388 ? -10.447 -23.684 -36.622 1.00 107.33 ? 409 THR   A CB  1 
ATOM   2777 O  OG1 . THR   A 1 388 ? -9.304  -22.843 -36.819 1.00 108.36 ? 409 THR   A OG1 1 
ATOM   2778 C  CG2 . THR   A 1 388 ? -10.909 -24.232 -37.966 1.00 109.66 ? 409 THR   A CG2 1 
ATOM   2779 N  N   . GLU   A 1 389 ? -13.882 -23.279 -36.580 1.00 101.74 ? 410 GLU   A N   1 
ATOM   2780 C  CA  . GLU   A 1 389 ? -15.217 -23.862 -36.496 1.00 102.51 ? 410 GLU   A CA  1 
ATOM   2781 C  C   . GLU   A 1 389 ? -15.630 -23.976 -35.033 1.00 102.32 ? 410 GLU   A C   1 
ATOM   2782 O  O   . GLU   A 1 389 ? -15.779 -25.089 -34.511 1.00 99.99  ? 410 GLU   A O   1 
ATOM   2783 C  CB  . GLU   A 1 389 ? -15.267 -25.224 -37.194 1.00 105.24 ? 410 GLU   A CB  1 
ATOM   2784 C  CG  . GLU   A 1 389 ? -15.094 -25.137 -38.705 1.00 107.40 ? 410 GLU   A CG  1 
ATOM   2785 C  CD  . GLU   A 1 389 ? -15.614 -26.362 -39.429 1.00 107.03 ? 410 GLU   A CD  1 
ATOM   2786 O  OE1 . GLU   A 1 389 ? -15.054 -27.460 -39.227 1.00 109.49 ? 410 GLU   A OE1 1 
ATOM   2787 O  OE2 . GLU   A 1 389 ? -16.593 -26.227 -40.194 1.00 103.54 ? 410 GLU   A OE2 1 
ATOM   2788 N  N   . PRO   A 1 390 ? -15.815 -22.847 -34.342 1.00 104.53 ? 411 PRO   A N   1 
ATOM   2789 C  CA  . PRO   A 1 390 ? -16.030 -22.902 -32.885 1.00 102.80 ? 411 PRO   A CA  1 
ATOM   2790 C  C   . PRO   A 1 390 ? -17.279 -23.657 -32.469 1.00 100.80 ? 411 PRO   A C   1 
ATOM   2791 O  O   . PRO   A 1 390 ? -17.308 -24.221 -31.368 1.00 101.16 ? 411 PRO   A O   1 
ATOM   2792 C  CB  . PRO   A 1 390 ? -16.112 -21.420 -32.494 1.00 101.89 ? 411 PRO   A CB  1 
ATOM   2793 C  CG  . PRO   A 1 390 ? -16.583 -20.733 -33.732 1.00 101.75 ? 411 PRO   A CG  1 
ATOM   2794 C  CD  . PRO   A 1 390 ? -15.949 -21.478 -34.871 1.00 103.49 ? 411 PRO   A CD  1 
ATOM   2795 N  N   . GLU   A 1 391 ? -18.313 -23.688 -33.311 1.00 99.49  ? 412 GLU   A N   1 
ATOM   2796 C  CA  . GLU   A 1 391 ? -19.572 -24.316 -32.931 1.00 96.99  ? 412 GLU   A CA  1 
ATOM   2797 C  C   . GLU   A 1 391 ? -19.504 -25.837 -32.918 1.00 96.77  ? 412 GLU   A C   1 
ATOM   2798 O  O   . GLU   A 1 391 ? -20.461 -26.475 -32.467 1.00 97.22  ? 412 GLU   A O   1 
ATOM   2799 C  CB  . GLU   A 1 391 ? -20.687 -23.853 -33.871 1.00 100.17 ? 412 GLU   A CB  1 
ATOM   2800 C  CG  . GLU   A 1 391 ? -20.868 -22.343 -33.907 1.00 101.82 ? 412 GLU   A CG  1 
ATOM   2801 C  CD  . GLU   A 1 391 ? -21.213 -21.764 -32.548 1.00 105.23 ? 412 GLU   A CD  1 
ATOM   2802 O  OE1 . GLU   A 1 391 ? -22.035 -22.375 -31.832 1.00 105.74 ? 412 GLU   A OE1 1 
ATOM   2803 O  OE2 . GLU   A 1 391 ? -20.658 -20.702 -32.192 1.00 104.31 ? 412 GLU   A OE2 1 
ATOM   2804 N  N   . LYS   A 1 392 ? -18.416 -26.432 -33.396 1.00 97.66  ? 413 LYS   A N   1 
ATOM   2805 C  CA  . LYS   A 1 392 ? -18.290 -27.880 -33.427 1.00 95.33  ? 413 LYS   A CA  1 
ATOM   2806 C  C   . LYS   A 1 392 ? -17.610 -28.392 -32.160 1.00 91.28  ? 413 LYS   A C   1 
ATOM   2807 O  O   . LYS   A 1 392 ? -17.041 -27.633 -31.372 1.00 95.91  ? 413 LYS   A O   1 
ATOM   2808 C  CB  . LYS   A 1 392 ? -17.511 -28.324 -34.664 1.00 93.80  ? 413 LYS   A CB  1 
ATOM   2809 C  CG  . LYS   A 1 392 ? -17.913 -27.603 -35.935 1.00 97.97  ? 413 LYS   A CG  1 
ATOM   2810 C  CD  . LYS   A 1 392 ? -17.358 -28.293 -37.168 1.00 98.11  ? 413 LYS   A CD  1 
ATOM   2811 C  CE  . LYS   A 1 392 ? -18.433 -29.093 -37.883 1.00 94.29  ? 413 LYS   A CE  1 
ATOM   2812 N  NZ  . LYS   A 1 392 ? -17.965 -29.574 -39.212 1.00 93.32  ? 413 LYS   A NZ  1 
ATOM   2813 N  N   . PHE   A 1 393 ? -17.676 -29.707 -31.971 1.00 87.74  ? 414 PHE   A N   1 
ATOM   2814 C  CA  . PHE   A 1 393 ? -17.059 -30.389 -30.836 1.00 86.98  ? 414 PHE   A CA  1 
ATOM   2815 C  C   . PHE   A 1 393 ? -15.822 -31.117 -31.350 1.00 91.86  ? 414 PHE   A C   1 
ATOM   2816 O  O   . PHE   A 1 393 ? -15.922 -32.206 -31.922 1.00 91.35  ? 414 PHE   A O   1 
ATOM   2817 C  CB  . PHE   A 1 393 ? -18.046 -31.349 -30.179 1.00 84.48  ? 414 PHE   A CB  1 
ATOM   2818 C  CG  . PHE   A 1 393 ? -17.444 -32.189 -29.089 1.00 89.29  ? 414 PHE   A CG  1 
ATOM   2819 C  CD1 . PHE   A 1 393 ? -17.208 -31.656 -27.833 1.00 90.41  ? 414 PHE   A CD1 1 
ATOM   2820 C  CD2 . PHE   A 1 393 ? -17.121 -33.517 -29.319 1.00 90.94  ? 414 PHE   A CD2 1 
ATOM   2821 C  CE1 . PHE   A 1 393 ? -16.655 -32.430 -26.828 1.00 91.14  ? 414 PHE   A CE1 1 
ATOM   2822 C  CE2 . PHE   A 1 393 ? -16.569 -34.296 -28.319 1.00 88.66  ? 414 PHE   A CE2 1 
ATOM   2823 C  CZ  . PHE   A 1 393 ? -16.336 -33.752 -27.072 1.00 89.90  ? 414 PHE   A CZ  1 
ATOM   2824 N  N   . LEU   A 1 394 ? -14.655 -30.509 -31.146 1.00 91.02  ? 415 LEU   A N   1 
ATOM   2825 C  CA  . LEU   A 1 394 ? -13.387 -31.030 -31.652 1.00 90.30  ? 415 LEU   A CA  1 
ATOM   2826 C  C   . LEU   A 1 394 ? -12.400 -31.132 -30.498 1.00 91.74  ? 415 LEU   A C   1 
ATOM   2827 O  O   . LEU   A 1 394 ? -11.711 -30.157 -30.166 1.00 93.87  ? 415 LEU   A O   1 
ATOM   2828 C  CB  . LEU   A 1 394 ? -12.841 -30.147 -32.773 1.00 92.61  ? 415 LEU   A CB  1 
ATOM   2829 C  CG  . LEU   A 1 394 ? -13.769 -29.968 -33.978 1.00 90.81  ? 415 LEU   A CG  1 
ATOM   2830 C  CD1 . LEU   A 1 394 ? -13.173 -29.000 -34.988 1.00 90.93  ? 415 LEU   A CD1 1 
ATOM   2831 C  CD2 . LEU   A 1 394 ? -14.074 -31.310 -34.630 1.00 89.29  ? 415 LEU   A CD2 1 
ATOM   2832 N  N   . PRO   A 1 395 ? -12.300 -32.302 -29.862 1.00 92.69  ? 416 PRO   A N   1 
ATOM   2833 C  CA  . PRO   A 1 395 ? -11.343 -32.455 -28.754 1.00 90.79  ? 416 PRO   A CA  1 
ATOM   2834 C  C   . PRO   A 1 395 ? -9.893  -32.270 -29.168 1.00 91.56  ? 416 PRO   A C   1 
ATOM   2835 O  O   . PRO   A 1 395 ? -9.046  -32.028 -28.300 1.00 94.68  ? 416 PRO   A O   1 
ATOM   2836 C  CB  . PRO   A 1 395 ? -11.603 -33.885 -28.256 1.00 88.81  ? 416 PRO   A CB  1 
ATOM   2837 C  CG  . PRO   A 1 395 ? -12.981 -34.218 -28.743 1.00 91.31  ? 416 PRO   A CG  1 
ATOM   2838 C  CD  . PRO   A 1 395 ? -13.121 -33.509 -30.055 1.00 94.09  ? 416 PRO   A CD  1 
ATOM   2839 N  N   . GLU   A 1 396 ? -9.581  -32.361 -30.464 1.00 95.13  ? 417 GLU   A N   1 
ATOM   2840 C  CA  . GLU   A 1 396 ? -8.205  -32.249 -30.932 1.00 96.23  ? 417 GLU   A CA  1 
ATOM   2841 C  C   . GLU   A 1 396 ? -7.615  -30.858 -30.732 1.00 97.11  ? 417 GLU   A C   1 
ATOM   2842 O  O   . GLU   A 1 396 ? -6.402  -30.695 -30.901 1.00 99.54  ? 417 GLU   A O   1 
ATOM   2843 C  CB  . GLU   A 1 396 ? -8.120  -32.632 -32.411 1.00 93.36  ? 417 GLU   A CB  1 
ATOM   2844 N  N   . ARG   A 1 397 ? -8.434  -29.857 -30.392 1.00 96.80  ? 418 ARG   A N   1 
ATOM   2845 C  CA  . ARG   A 1 397 ? -7.898  -28.531 -30.102 1.00 96.73  ? 418 ARG   A CA  1 
ATOM   2846 C  C   . ARG   A 1 397 ? -6.928  -28.564 -28.930 1.00 93.69  ? 418 ARG   A C   1 
ATOM   2847 O  O   . ARG   A 1 397 ? -5.978  -27.773 -28.887 1.00 97.26  ? 418 ARG   A O   1 
ATOM   2848 C  CB  . ARG   A 1 397 ? -9.029  -27.549 -29.794 1.00 94.61  ? 418 ARG   A CB  1 
ATOM   2849 C  CG  . ARG   A 1 397 ? -10.086 -27.400 -30.870 1.00 92.88  ? 418 ARG   A CG  1 
ATOM   2850 C  CD  . ARG   A 1 397 ? -11.120 -26.376 -30.428 1.00 91.63  ? 418 ARG   A CD  1 
ATOM   2851 N  NE  . ARG   A 1 397 ? -12.351 -26.451 -31.204 1.00 94.54  ? 418 ARG   A NE  1 
ATOM   2852 C  CZ  . ARG   A 1 397 ? -12.600 -25.724 -32.285 1.00 99.32  ? 418 ARG   A CZ  1 
ATOM   2853 N  NH1 . ARG   A 1 397 ? -11.718 -24.857 -32.753 1.00 100.56 ? 418 ARG   A NH1 1 
ATOM   2854 N  NH2 . ARG   A 1 397 ? -13.764 -25.873 -32.912 1.00 100.10 ? 418 ARG   A NH2 1 
ATOM   2855 N  N   . PHE   A 1 398 ? -7.148  -29.466 -27.974 1.00 91.79  ? 419 PHE   A N   1 
ATOM   2856 C  CA  . PHE   A 1 398 ? -6.362  -29.527 -26.750 1.00 93.90  ? 419 PHE   A CA  1 
ATOM   2857 C  C   . PHE   A 1 398 ? -5.326  -30.645 -26.773 1.00 95.58  ? 419 PHE   A C   1 
ATOM   2858 O  O   . PHE   A 1 398 ? -4.786  -31.003 -25.720 1.00 95.74  ? 419 PHE   A O   1 
ATOM   2859 C  CB  . PHE   A 1 398 ? -7.287  -29.672 -25.542 1.00 94.81  ? 419 PHE   A CB  1 
ATOM   2860 C  CG  . PHE   A 1 398 ? -8.167  -28.476 -25.311 1.00 90.07  ? 419 PHE   A CG  1 
ATOM   2861 C  CD1 . PHE   A 1 398 ? -9.392  -28.366 -25.948 1.00 88.87  ? 419 PHE   A CD1 1 
ATOM   2862 C  CD2 . PHE   A 1 398 ? -7.764  -27.458 -24.463 1.00 88.36  ? 419 PHE   A CD2 1 
ATOM   2863 C  CE1 . PHE   A 1 398 ? -10.201 -27.265 -25.741 1.00 88.06  ? 419 PHE   A CE1 1 
ATOM   2864 C  CE2 . PHE   A 1 398 ? -8.569  -26.355 -24.252 1.00 87.86  ? 419 PHE   A CE2 1 
ATOM   2865 C  CZ  . PHE   A 1 398 ? -9.789  -26.259 -24.892 1.00 87.87  ? 419 PHE   A CZ  1 
ATOM   2866 N  N   . SER   A 1 399 ? -5.046  -31.208 -27.944 1.00 97.95  ? 420 SER   A N   1 
ATOM   2867 C  CA  . SER   A 1 399 ? -3.911  -32.106 -28.081 1.00 96.70  ? 420 SER   A CA  1 
ATOM   2868 C  C   . SER   A 1 399 ? -2.614  -31.330 -27.889 1.00 96.76  ? 420 SER   A C   1 
ATOM   2869 O  O   . SER   A 1 399 ? -2.544  -30.126 -28.146 1.00 95.59  ? 420 SER   A O   1 
ATOM   2870 C  CB  . SER   A 1 399 ? -3.924  -32.788 -29.450 1.00 96.61  ? 420 SER   A CB  1 
ATOM   2871 O  OG  . SER   A 1 399 ? -3.837  -31.836 -30.495 1.00 96.91  ? 420 SER   A OG  1 
ATOM   2872 N  N   . LYS   A 1 400 ? -1.577  -32.040 -27.434 1.00 99.88  ? 421 LYS   A N   1 
ATOM   2873 C  CA  . LYS   A 1 400 ? -0.317  -31.388 -27.081 1.00 96.54  ? 421 LYS   A CA  1 
ATOM   2874 C  C   . LYS   A 1 400 ? 0.253   -30.574 -28.237 1.00 95.51  ? 421 LYS   A C   1 
ATOM   2875 O  O   . LYS   A 1 400 ? 0.922   -29.561 -28.009 1.00 96.42  ? 421 LYS   A O   1 
ATOM   2876 C  CB  . LYS   A 1 400 ? 0.700   -32.431 -26.616 1.00 91.96  ? 421 LYS   A CB  1 
ATOM   2877 N  N   . LYS   A 1 401 ? 0.004   -30.998 -29.478 1.00 96.85  ? 422 LYS   A N   1 
ATOM   2878 C  CA  . LYS   A 1 401 ? 0.474   -30.231 -30.628 1.00 98.72  ? 422 LYS   A CA  1 
ATOM   2879 C  C   . LYS   A 1 401 ? -0.232  -28.882 -30.722 1.00 100.31 ? 422 LYS   A C   1 
ATOM   2880 O  O   . LYS   A 1 401 ? 0.414   -27.853 -30.950 1.00 101.62 ? 422 LYS   A O   1 
ATOM   2881 C  CB  . LYS   A 1 401 ? 0.272   -31.035 -31.911 1.00 96.40  ? 422 LYS   A CB  1 
ATOM   2882 N  N   . ASN   A 1 402 ? -1.551  -28.866 -30.544 1.00 102.05 ? 423 ASN   A N   1 
ATOM   2883 C  CA  . ASN   A 1 402 ? -2.344  -27.647 -30.634 1.00 99.25  ? 423 ASN   A CA  1 
ATOM   2884 C  C   . ASN   A 1 402 ? -2.638  -27.025 -29.276 1.00 98.22  ? 423 ASN   A C   1 
ATOM   2885 O  O   . ASN   A 1 402 ? -3.351  -26.018 -29.214 1.00 93.74  ? 423 ASN   A O   1 
ATOM   2886 C  CB  . ASN   A 1 402 ? -3.661  -27.933 -31.364 1.00 99.04  ? 423 ASN   A CB  1 
ATOM   2887 C  CG  . ASN   A 1 402 ? -3.449  -28.594 -32.712 1.00 104.40 ? 423 ASN   A CG  1 
ATOM   2888 O  OD1 . ASN   A 1 402 ? -2.317  -28.880 -33.103 1.00 108.21 ? 423 ASN   A OD1 1 
ATOM   2889 N  ND2 . ASN   A 1 402 ? -4.540  -28.850 -33.426 1.00 107.41 ? 423 ASN   A ND2 1 
ATOM   2890 N  N   . LYS   A 1 403 ? -2.109  -27.594 -28.190 1.00 99.40  ? 424 LYS   A N   1 
ATOM   2891 C  CA  . LYS   A 1 403 ? -2.459  -27.118 -26.855 1.00 96.57  ? 424 LYS   A CA  1 
ATOM   2892 C  C   . LYS   A 1 403 ? -1.862  -25.744 -26.570 1.00 98.98  ? 424 LYS   A C   1 
ATOM   2893 O  O   . LYS   A 1 403 ? -2.537  -24.875 -26.005 1.00 98.62  ? 424 LYS   A O   1 
ATOM   2894 C  CB  . LYS   A 1 403 ? -2.003  -28.130 -25.804 1.00 95.97  ? 424 LYS   A CB  1 
ATOM   2895 C  CG  . LYS   A 1 403 ? -2.431  -27.791 -24.388 1.00 97.72  ? 424 LYS   A CG  1 
ATOM   2896 C  CD  . LYS   A 1 403 ? -2.136  -28.934 -23.429 1.00 94.35  ? 424 LYS   A CD  1 
ATOM   2897 C  CE  . LYS   A 1 403 ? -0.647  -29.224 -23.345 1.00 91.91  ? 424 LYS   A CE  1 
ATOM   2898 N  NZ  . LYS   A 1 403 ? -0.348  -30.283 -22.341 1.00 92.86  ? 424 LYS   A NZ  1 
ATOM   2899 N  N   . ASP   A 1 404 ? -0.604  -25.523 -26.954 1.00 101.62 ? 425 ASP   A N   1 
ATOM   2900 C  CA  . ASP   A 1 404 ? 0.091   -24.292 -26.596 1.00 103.54 ? 425 ASP   A CA  1 
ATOM   2901 C  C   . ASP   A 1 404 ? -0.342  -23.087 -27.422 1.00 100.53 ? 425 ASP   A C   1 
ATOM   2902 O  O   . ASP   A 1 404 ? 0.046   -21.961 -27.089 1.00 98.00  ? 425 ASP   A O   1 
ATOM   2903 C  CB  . ASP   A 1 404 ? 1.605   -24.486 -26.719 1.00 105.79 ? 425 ASP   A CB  1 
ATOM   2904 C  CG  . ASP   A 1 404 ? 2.218   -25.087 -25.466 1.00 110.27 ? 425 ASP   A CG  1 
ATOM   2905 O  OD1 . ASP   A 1 404 ? 1.769   -24.731 -24.355 1.00 106.36 ? 425 ASP   A OD1 1 
ATOM   2906 O  OD2 . ASP   A 1 404 ? 3.145   -25.915 -25.590 1.00 114.64 ? 425 ASP   A OD2 1 
ATOM   2907 N  N   . ASN   A 1 405 ? -1.135  -23.282 -28.473 1.00 98.74  ? 426 ASN   A N   1 
ATOM   2908 C  CA  . ASN   A 1 405 ? -1.632  -22.163 -29.263 1.00 98.63  ? 426 ASN   A CA  1 
ATOM   2909 C  C   . ASN   A 1 405 ? -2.883  -21.529 -28.666 1.00 95.79  ? 426 ASN   A C   1 
ATOM   2910 O  O   . ASN   A 1 405 ? -3.387  -20.549 -29.223 1.00 92.81  ? 426 ASN   A O   1 
ATOM   2911 C  CB  . ASN   A 1 405 ? -1.914  -22.614 -30.699 1.00 100.93 ? 426 ASN   A CB  1 
ATOM   2912 C  CG  . ASN   A 1 405 ? -0.669  -23.114 -31.406 1.00 104.25 ? 426 ASN   A CG  1 
ATOM   2913 O  OD1 . ASN   A 1 405 ? 0.446   -22.696 -31.094 1.00 106.63 ? 426 ASN   A OD1 1 
ATOM   2914 N  ND2 . ASN   A 1 405 ? -0.854  -24.015 -32.365 1.00 105.92 ? 426 ASN   A ND2 1 
ATOM   2915 N  N   . ILE   A 1 406 ? -3.388  -22.056 -27.554 1.00 95.57  ? 427 ILE   A N   1 
ATOM   2916 C  CA  . ILE   A 1 406 ? -4.578  -21.520 -26.904 1.00 90.04  ? 427 ILE   A CA  1 
ATOM   2917 C  C   . ILE   A 1 406 ? -4.145  -20.482 -25.876 1.00 90.63  ? 427 ILE   A C   1 
ATOM   2918 O  O   . ILE   A 1 406 ? -3.322  -20.768 -24.999 1.00 88.00  ? 427 ILE   A O   1 
ATOM   2919 C  CB  . ILE   A 1 406 ? -5.405  -22.636 -26.249 1.00 88.38  ? 427 ILE   A CB  1 
ATOM   2920 N  N   . ASP   A 1 407 ? -4.694  -19.281 -25.988 1.00 89.08  ? 428 ASP   A N   1 
ATOM   2921 C  CA  . ASP   A 1 407 ? -4.369  -18.203 -25.062 1.00 86.48  ? 428 ASP   A CA  1 
ATOM   2922 C  C   . ASP   A 1 407 ? -5.046  -18.460 -23.721 1.00 83.83  ? 428 ASP   A C   1 
ATOM   2923 O  O   . ASP   A 1 407 ? -6.274  -18.619 -23.681 1.00 83.26  ? 428 ASP   A O   1 
ATOM   2924 C  CB  . ASP   A 1 407 ? -4.813  -16.864 -25.650 1.00 85.12  ? 428 ASP   A CB  1 
ATOM   2925 C  CG  . ASP   A 1 407 ? -4.152  -15.673 -24.979 1.00 82.82  ? 428 ASP   A CG  1 
ATOM   2926 O  OD1 . ASP   A 1 407 ? -4.073  -15.648 -23.733 1.00 80.77  ? 428 ASP   A OD1 1 
ATOM   2927 O  OD2 . ASP   A 1 407 ? -3.711  -14.755 -25.703 1.00 78.34  ? 428 ASP   A OD2 1 
ATOM   2928 N  N   . PRO   A 1 408 ? -4.305  -18.504 -22.609 1.00 81.91  ? 429 PRO   A N   1 
ATOM   2929 C  CA  . PRO   A 1 408 ? -4.922  -18.835 -21.315 1.00 80.27  ? 429 PRO   A CA  1 
ATOM   2930 C  C   . PRO   A 1 408 ? -5.900  -17.791 -20.798 1.00 79.48  ? 429 PRO   A C   1 
ATOM   2931 O  O   . PRO   A 1 408 ? -6.539  -18.028 -19.767 1.00 77.49  ? 429 PRO   A O   1 
ATOM   2932 C  CB  . PRO   A 1 408 ? -3.711  -18.966 -20.377 1.00 77.74  ? 429 PRO   A CB  1 
ATOM   2933 C  CG  . PRO   A 1 408 ? -2.649  -18.135 -21.015 1.00 81.87  ? 429 PRO   A CG  1 
ATOM   2934 C  CD  . PRO   A 1 408 ? -2.852  -18.294 -22.493 1.00 82.50  ? 429 PRO   A CD  1 
ATOM   2935 N  N   . TYR   A 1 409 ? -6.040  -16.647 -21.466 1.00 79.48  ? 430 TYR   A N   1 
ATOM   2936 C  CA  . TYR   A 1 409 ? -6.984  -15.620 -21.052 1.00 76.87  ? 430 TYR   A CA  1 
ATOM   2937 C  C   . TYR   A 1 409 ? -8.192  -15.524 -21.971 1.00 79.85  ? 430 TYR   A C   1 
ATOM   2938 O  O   . TYR   A 1 409 ? -9.097  -14.725 -21.703 1.00 76.84  ? 430 TYR   A O   1 
ATOM   2939 C  CB  . TYR   A 1 409 ? -6.273  -14.267 -20.954 1.00 79.66  ? 430 TYR   A CB  1 
ATOM   2940 C  CG  . TYR   A 1 409 ? -5.114  -14.309 -19.988 1.00 82.90  ? 430 TYR   A CG  1 
ATOM   2941 C  CD1 . TYR   A 1 409 ? -5.326  -14.210 -18.619 1.00 83.88  ? 430 TYR   A CD1 1 
ATOM   2942 C  CD2 . TYR   A 1 409 ? -3.813  -14.477 -20.440 1.00 82.41  ? 430 TYR   A CD2 1 
ATOM   2943 C  CE1 . TYR   A 1 409 ? -4.272  -14.261 -17.728 1.00 88.22  ? 430 TYR   A CE1 1 
ATOM   2944 C  CE2 . TYR   A 1 409 ? -2.751  -14.530 -19.556 1.00 79.56  ? 430 TYR   A CE2 1 
ATOM   2945 C  CZ  . TYR   A 1 409 ? -2.987  -14.421 -18.202 1.00 85.06  ? 430 TYR   A CZ  1 
ATOM   2946 O  OH  . TYR   A 1 409 ? -1.936  -14.472 -17.315 1.00 87.48  ? 430 TYR   A OH  1 
ATOM   2947 N  N   . ILE   A 1 410 ? -8.231  -16.312 -23.040 1.00 81.55  ? 431 ILE   A N   1 
ATOM   2948 C  CA  . ILE   A 1 410 ? -9.447  -16.475 -23.830 1.00 79.62  ? 431 ILE   A CA  1 
ATOM   2949 C  C   . ILE   A 1 410 ? -10.245 -17.681 -23.355 1.00 77.65  ? 431 ILE   A C   1 
ATOM   2950 O  O   . ILE   A 1 410 ? -11.466 -17.610 -23.189 1.00 79.48  ? 431 ILE   A O   1 
ATOM   2951 C  CB  . ILE   A 1 410 ? -9.094  -16.586 -25.328 1.00 75.74  ? 431 ILE   A CB  1 
ATOM   2952 C  CG1 . ILE   A 1 410 ? -8.273  -15.375 -25.771 1.00 79.84  ? 431 ILE   A CG1 1 
ATOM   2953 C  CG2 . ILE   A 1 410 ? -10.358 -16.718 -26.165 1.00 78.41  ? 431 ILE   A CG2 1 
ATOM   2954 C  CD1 . ILE   A 1 410 ? -8.986  -14.056 -25.590 1.00 82.27  ? 431 ILE   A CD1 1 
ATOM   2955 N  N   . TYR   A 1 411 ? -9.564  -18.802 -23.125 1.00 75.97  ? 432 TYR   A N   1 
ATOM   2956 C  CA  . TYR   A 1 411 ? -10.187 -20.008 -22.583 1.00 78.11  ? 432 TYR   A CA  1 
ATOM   2957 C  C   . TYR   A 1 411 ? -10.012 -19.983 -21.069 1.00 79.37  ? 432 TYR   A C   1 
ATOM   2958 O  O   . TYR   A 1 411 ? -8.953  -20.339 -20.547 1.00 77.49  ? 432 TYR   A O   1 
ATOM   2959 C  CB  . TYR   A 1 411 ? -9.571  -21.258 -23.205 1.00 76.54  ? 432 TYR   A CB  1 
ATOM   2960 C  CG  . TYR   A 1 411 ? -10.059 -22.561 -22.608 1.00 77.70  ? 432 TYR   A CG  1 
ATOM   2961 C  CD1 . TYR   A 1 411 ? -11.334 -23.038 -22.880 1.00 80.38  ? 432 TYR   A CD1 1 
ATOM   2962 C  CD2 . TYR   A 1 411 ? -9.240  -23.319 -21.782 1.00 75.27  ? 432 TYR   A CD2 1 
ATOM   2963 C  CE1 . TYR   A 1 411 ? -11.782 -24.229 -22.339 1.00 79.31  ? 432 TYR   A CE1 1 
ATOM   2964 C  CE2 . TYR   A 1 411 ? -9.680  -24.512 -21.238 1.00 75.91  ? 432 TYR   A CE2 1 
ATOM   2965 C  CZ  . TYR   A 1 411 ? -10.952 -24.962 -21.520 1.00 77.20  ? 432 TYR   A CZ  1 
ATOM   2966 O  OH  . TYR   A 1 411 ? -11.399 -26.147 -20.982 1.00 77.98  ? 432 TYR   A OH  1 
ATOM   2967 N  N   . THR   A 1 412 ? -11.056 -19.558 -20.360 1.00 78.18  ? 433 THR   A N   1 
ATOM   2968 C  CA  . THR   A 1 412 ? -11.024 -19.409 -18.905 1.00 76.22  ? 433 THR   A CA  1 
ATOM   2969 C  C   . THR   A 1 412 ? -12.226 -20.120 -18.292 1.00 76.22  ? 433 THR   A C   1 
ATOM   2970 O  O   . THR   A 1 412 ? -13.131 -19.478 -17.743 1.00 72.91  ? 433 THR   A O   1 
ATOM   2971 C  CB  . THR   A 1 412 ? -11.009 -17.931 -18.507 1.00 79.03  ? 433 THR   A CB  1 
ATOM   2972 O  OG1 . THR   A 1 412 ? -12.152 -17.272 -19.066 1.00 76.55  ? 433 THR   A OG1 1 
ATOM   2973 C  CG2 . THR   A 1 412 ? -9.740  -17.249 -19.007 1.00 76.16  ? 433 THR   A CG2 1 
ATOM   2974 N  N   . PRO   A 1 413 ? -12.267 -21.454 -18.369 1.00 78.24  ? 434 PRO   A N   1 
ATOM   2975 C  CA  . PRO   A 1 413 ? -13.394 -22.179 -17.760 1.00 78.04  ? 434 PRO   A CA  1 
ATOM   2976 C  C   . PRO   A 1 413 ? -13.460 -22.031 -16.251 1.00 76.52  ? 434 PRO   A C   1 
ATOM   2977 O  O   . PRO   A 1 413 ? -14.559 -22.031 -15.684 1.00 76.23  ? 434 PRO   A O   1 
ATOM   2978 C  CB  . PRO   A 1 413 ? -13.135 -23.633 -18.175 1.00 72.50  ? 434 PRO   A CB  1 
ATOM   2979 C  CG  . PRO   A 1 413 ? -11.658 -23.709 -18.321 1.00 75.32  ? 434 PRO   A CG  1 
ATOM   2980 C  CD  . PRO   A 1 413 ? -11.230 -22.373 -18.870 1.00 77.11  ? 434 PRO   A CD  1 
ATOM   2981 N  N   . PHE   A 1 414 ? -12.313 -21.903 -15.582 1.00 77.35  ? 435 PHE   A N   1 
ATOM   2982 C  CA  . PHE   A 1 414 ? -12.252 -21.804 -14.130 1.00 76.33  ? 435 PHE   A CA  1 
ATOM   2983 C  C   . PHE   A 1 414 ? -11.754 -20.441 -13.666 1.00 73.07  ? 435 PHE   A C   1 
ATOM   2984 O  O   . PHE   A 1 414 ? -11.212 -20.326 -12.562 1.00 68.17  ? 435 PHE   A O   1 
ATOM   2985 C  CB  . PHE   A 1 414 ? -11.360 -22.907 -13.560 1.00 72.77  ? 435 PHE   A CB  1 
ATOM   2986 C  CG  . PHE   A 1 414 ? -11.881 -24.291 -13.799 1.00 75.91  ? 435 PHE   A CG  1 
ATOM   2987 C  CD1 . PHE   A 1 414 ? -11.553 -24.978 -14.955 1.00 77.01  ? 435 PHE   A CD1 1 
ATOM   2988 C  CD2 . PHE   A 1 414 ? -12.695 -24.908 -12.865 1.00 77.11  ? 435 PHE   A CD2 1 
ATOM   2989 C  CE1 . PHE   A 1 414 ? -12.030 -26.255 -15.174 1.00 77.52  ? 435 PHE   A CE1 1 
ATOM   2990 C  CE2 . PHE   A 1 414 ? -13.174 -26.186 -13.079 1.00 76.31  ? 435 PHE   A CE2 1 
ATOM   2991 C  CZ  . PHE   A 1 414 ? -12.842 -26.860 -14.235 1.00 77.37  ? 435 PHE   A CZ  1 
ATOM   2992 N  N   . GLY   A 1 415 ? -11.919 -19.411 -14.487 1.00 72.60  ? 436 GLY   A N   1 
ATOM   2993 C  CA  . GLY   A 1 415 ? -11.379 -18.116 -14.146 1.00 68.06  ? 436 GLY   A CA  1 
ATOM   2994 C  C   . GLY   A 1 415 ? -9.862  -18.114 -14.262 1.00 68.93  ? 436 GLY   A C   1 
ATOM   2995 O  O   . GLY   A 1 415 ? -9.242  -19.014 -14.833 1.00 70.89  ? 436 GLY   A O   1 
ATOM   2996 N  N   . SER   A 1 416 ? -9.265  -17.074 -13.687 1.00 71.73  ? 437 SER   A N   1 
ATOM   2997 C  CA  . SER   A 1 416 ? -7.816  -16.923 -13.711 1.00 71.85  ? 437 SER   A CA  1 
ATOM   2998 C  C   . SER   A 1 416 ? -7.401  -15.983 -12.588 1.00 72.06  ? 437 SER   A C   1 
ATOM   2999 O  O   . SER   A 1 416 ? -8.237  -15.384 -11.908 1.00 72.06  ? 437 SER   A O   1 
ATOM   3000 C  CB  . SER   A 1 416 ? -7.332  -16.411 -15.070 1.00 69.96  ? 437 SER   A CB  1 
ATOM   3001 O  OG  . SER   A 1 416 ? -5.922  -16.277 -15.093 1.00 73.26  ? 437 SER   A OG  1 
ATOM   3002 N  N   . GLY   A 1 417 ? -6.089  -15.871 -12.396 1.00 72.94  ? 438 GLY   A N   1 
ATOM   3003 C  CA  . GLY   A 1 417 ? -5.538  -15.015 -11.375 1.00 72.23  ? 438 GLY   A CA  1 
ATOM   3004 C  C   . GLY   A 1 417 ? -5.738  -15.574 -9.981  1.00 72.53  ? 438 GLY   A C   1 
ATOM   3005 O  O   . GLY   A 1 417 ? -6.108  -16.737 -9.799  1.00 71.02  ? 438 GLY   A O   1 
ATOM   3006 N  N   . PRO   A 1 418 ? -5.493  -14.745 -8.964  1.00 74.39  ? 439 PRO   A N   1 
ATOM   3007 C  CA  . PRO   A 1 418 ? -5.646  -15.217 -7.578  1.00 72.94  ? 439 PRO   A CA  1 
ATOM   3008 C  C   . PRO   A 1 418 ? -7.064  -15.627 -7.211  1.00 71.91  ? 439 PRO   A C   1 
ATOM   3009 O  O   . PRO   A 1 418 ? -7.235  -16.406 -6.265  1.00 73.78  ? 439 PRO   A O   1 
ATOM   3010 C  CB  . PRO   A 1 418 ? -5.179  -14.014 -6.743  1.00 69.81  ? 439 PRO   A CB  1 
ATOM   3011 C  CG  . PRO   A 1 418 ? -4.373  -13.169 -7.686  1.00 72.62  ? 439 PRO   A CG  1 
ATOM   3012 C  CD  . PRO   A 1 418 ? -4.995  -13.361 -9.030  1.00 74.17  ? 439 PRO   A CD  1 
ATOM   3013 N  N   . ARG   A 1 419 ? -8.084  -15.142 -7.921  1.00 71.07  ? 440 ARG   A N   1 
ATOM   3014 C  CA  . ARG   A 1 419 ? -9.476  -15.412 -7.579  1.00 74.09  ? 440 ARG   A CA  1 
ATOM   3015 C  C   . ARG   A 1 419 ? -10.133 -16.384 -8.558  1.00 74.08  ? 440 ARG   A C   1 
ATOM   3016 O  O   . ARG   A 1 419 ? -11.330 -16.281 -8.838  1.00 73.08  ? 440 ARG   A O   1 
ATOM   3017 C  CB  . ARG   A 1 419 ? -10.273 -14.111 -7.507  1.00 75.22  ? 440 ARG   A CB  1 
ATOM   3018 C  CG  . ARG   A 1 419 ? -11.285 -14.062 -6.370  1.00 73.92  ? 440 ARG   A CG  1 
ATOM   3019 C  CD  . ARG   A 1 419 ? -11.952 -12.698 -6.299  1.00 75.32  ? 440 ARG   A CD  1 
ATOM   3020 N  NE  . ARG   A 1 419 ? -12.268 -12.303 -4.931  1.00 75.11  ? 440 ARG   A NE  1 
ATOM   3021 C  CZ  . ARG   A 1 419 ? -13.454 -12.454 -4.358  1.00 73.02  ? 440 ARG   A CZ  1 
ATOM   3022 N  NH1 . ARG   A 1 419 ? -14.473 -12.992 -5.007  1.00 73.88  ? 440 ARG   A NH1 1 
ATOM   3023 N  NH2 . ARG   A 1 419 ? -13.623 -12.052 -3.101  1.00 75.61  ? 440 ARG   A NH2 1 
ATOM   3024 N  N   . ASN   A 1 420 ? -9.364  -17.335 -9.082  1.00 72.49  ? 441 ASN   A N   1 
ATOM   3025 C  CA  . ASN   A 1 420 ? -9.917  -18.368 -9.942  1.00 70.71  ? 441 ASN   A CA  1 
ATOM   3026 C  C   . ASN   A 1 420 ? -10.653 -19.402 -9.093  1.00 68.71  ? 441 ASN   A C   1 
ATOM   3027 O  O   . ASN   A 1 420 ? -10.759 -19.279 -7.870  1.00 71.09  ? 441 ASN   A O   1 
ATOM   3028 C  CB  . ASN   A 1 420 ? -8.813  -19.013 -10.780 1.00 71.35  ? 441 ASN   A CB  1 
ATOM   3029 C  CG  . ASN   A 1 420 ? -7.837  -19.825 -9.943  1.00 75.94  ? 441 ASN   A CG  1 
ATOM   3030 O  OD1 . ASN   A 1 420 ? -7.714  -19.623 -8.734  1.00 78.74  ? 441 ASN   A OD1 1 
ATOM   3031 N  ND2 . ASN   A 1 420 ? -7.130  -20.744 -10.591 1.00 78.93  ? 441 ASN   A ND2 1 
ATOM   3032 N  N   . CYS   A 1 421 ? -11.168 -20.441 -9.745  1.00 69.49  ? 442 CYS   A N   1 
ATOM   3033 C  CA  . CYS   A 1 421 ? -11.876 -21.489 -9.022  1.00 70.69  ? 442 CYS   A CA  1 
ATOM   3034 C  C   . CYS   A 1 421 ? -10.897 -22.257 -8.143  1.00 72.38  ? 442 CYS   A C   1 
ATOM   3035 O  O   . CYS   A 1 421 ? -9.970  -22.900 -8.648  1.00 72.65  ? 442 CYS   A O   1 
ATOM   3036 C  CB  . CYS   A 1 421 ? -12.577 -22.430 -9.996  1.00 72.46  ? 442 CYS   A CB  1 
ATOM   3037 S  SG  . CYS   A 1 421 ? -13.460 -23.788 -9.193  1.00 71.93  ? 442 CYS   A SG  1 
ATOM   3038 N  N   . ILE   A 1 422 ? -11.101 -22.188 -6.825  1.00 73.35  ? 443 ILE   A N   1 
ATOM   3039 C  CA  . ILE   A 1 422 ? -10.206 -22.861 -5.891  1.00 77.52  ? 443 ILE   A CA  1 
ATOM   3040 C  C   . ILE   A 1 422 ? -10.402 -24.371 -5.917  1.00 80.98  ? 443 ILE   A C   1 
ATOM   3041 O  O   . ILE   A 1 422 ? -9.471  -25.120 -5.595  1.00 83.14  ? 443 ILE   A O   1 
ATOM   3042 C  CB  . ILE   A 1 422 ? -10.402 -22.299 -4.468  1.00 76.72  ? 443 ILE   A CB  1 
ATOM   3043 C  CG1 . ILE   A 1 422 ? -9.211  -22.655 -3.576  1.00 81.75  ? 443 ILE   A CG1 1 
ATOM   3044 C  CG2 . ILE   A 1 422 ? -11.697 -22.814 -3.857  1.00 76.29  ? 443 ILE   A CG2 1 
ATOM   3045 C  CD1 . ILE   A 1 422 ? -9.337  -22.142 -2.158  1.00 83.15  ? 443 ILE   A CD1 1 
ATOM   3046 N  N   . GLY   A 1 423 ? -11.585 -24.841 -6.307  1.00 76.73  ? 444 GLY   A N   1 
ATOM   3047 C  CA  . GLY   A 1 423 ? -11.861 -26.263 -6.356  1.00 79.68  ? 444 GLY   A CA  1 
ATOM   3048 C  C   . GLY   A 1 423 ? -11.677 -26.852 -7.739  1.00 80.18  ? 444 GLY   A C   1 
ATOM   3049 O  O   . GLY   A 1 423 ? -12.286 -27.874 -8.071  1.00 78.99  ? 444 GLY   A O   1 
ATOM   3050 N  N   . MET   A 1 424 ? -10.840 -26.207 -8.555  1.00 79.89  ? 445 MET   A N   1 
ATOM   3051 C  CA  . MET   A 1 424 ? -10.640 -26.650 -9.933  1.00 78.77  ? 445 MET   A CA  1 
ATOM   3052 C  C   . MET   A 1 424 ? -10.074 -28.064 -9.989  1.00 85.71  ? 445 MET   A C   1 
ATOM   3053 O  O   . MET   A 1 424 ? -10.599 -28.927 -10.702 1.00 87.31  ? 445 MET   A O   1 
ATOM   3054 C  CB  . MET   A 1 424 ? -9.719  -25.671 -10.665 1.00 73.98  ? 445 MET   A CB  1 
ATOM   3055 C  CG  . MET   A 1 424 ? -9.291  -26.128 -12.051 1.00 77.06  ? 445 MET   A CG  1 
ATOM   3056 S  SD  . MET   A 1 424 ? -8.260  -24.910 -12.897 1.00 83.69  ? 445 MET   A SD  1 
ATOM   3057 C  CE  . MET   A 1 424 ? -6.911  -24.735 -11.731 1.00 84.95  ? 445 MET   A CE  1 
ATOM   3058 N  N   . ARG   A 1 425 ? -9.000  -28.324 -9.240  1.00 88.27  ? 446 ARG   A N   1 
ATOM   3059 C  CA  . ARG   A 1 425 ? -8.366  -29.638 -9.303  1.00 90.76  ? 446 ARG   A CA  1 
ATOM   3060 C  C   . ARG   A 1 425 ? -9.271  -30.722 -8.728  1.00 90.44  ? 446 ARG   A C   1 
ATOM   3061 O  O   . ARG   A 1 425 ? -9.321  -31.838 -9.259  1.00 92.74  ? 446 ARG   A O   1 
ATOM   3062 C  CB  . ARG   A 1 425 ? -7.018  -29.609 -8.582  1.00 95.39  ? 446 ARG   A CB  1 
ATOM   3063 C  CG  . ARG   A 1 425 ? -6.002  -28.688 -9.242  1.00 97.17  ? 446 ARG   A CG  1 
ATOM   3064 C  CD  . ARG   A 1 425 ? -4.608  -29.296 -9.248  1.00 105.56 ? 446 ARG   A CD  1 
ATOM   3065 N  NE  . ARG   A 1 425 ? -3.997  -29.301 -7.925  1.00 110.97 ? 446 ARG   A NE  1 
ATOM   3066 C  CZ  . ARG   A 1 425 ? -3.310  -28.287 -7.417  1.00 114.34 ? 446 ARG   A CZ  1 
ATOM   3067 N  NH1 . ARG   A 1 425 ? -3.143  -27.159 -8.089  1.00 114.40 ? 446 ARG   A NH1 1 
ATOM   3068 N  NH2 . ARG   A 1 425 ? -2.776  -28.407 -6.205  1.00 111.16 ? 446 ARG   A NH2 1 
ATOM   3069 N  N   . PHE   A 1 426 ? -9.989  -30.419 -7.644  1.00 90.19  ? 447 PHE   A N   1 
ATOM   3070 C  CA  . PHE   A 1 426 ? -10.936 -31.384 -7.092  1.00 90.58  ? 447 PHE   A CA  1 
ATOM   3071 C  C   . PHE   A 1 426 ? -12.048 -31.690 -8.088  1.00 92.21  ? 447 PHE   A C   1 
ATOM   3072 O  O   . PHE   A 1 426 ? -12.396 -32.856 -8.311  1.00 92.85  ? 447 PHE   A O   1 
ATOM   3073 C  CB  . PHE   A 1 426 ? -11.522 -30.858 -5.779  1.00 89.15  ? 447 PHE   A CB  1 
ATOM   3074 C  CG  . PHE   A 1 426 ? -12.647 -31.699 -5.231  1.00 91.42  ? 447 PHE   A CG  1 
ATOM   3075 C  CD1 . PHE   A 1 426 ? -12.383 -32.787 -4.416  1.00 93.47  ? 447 PHE   A CD1 1 
ATOM   3076 C  CD2 . PHE   A 1 426 ? -13.968 -31.395 -5.526  1.00 93.51  ? 447 PHE   A CD2 1 
ATOM   3077 C  CE1 . PHE   A 1 426 ? -13.413 -33.559 -3.910  1.00 96.62  ? 447 PHE   A CE1 1 
ATOM   3078 C  CE2 . PHE   A 1 426 ? -15.002 -32.166 -5.025  1.00 95.93  ? 447 PHE   A CE2 1 
ATOM   3079 C  CZ  . PHE   A 1 426 ? -14.724 -33.248 -4.216  1.00 98.01  ? 447 PHE   A CZ  1 
ATOM   3080 N  N   . ALA   A 1 427 ? -12.619 -30.648 -8.697  1.00 89.40  ? 448 ALA   A N   1 
ATOM   3081 C  CA  . ALA   A 1 427 ? -13.716 -30.848 -9.638  1.00 86.54  ? 448 ALA   A CA  1 
ATOM   3082 C  C   . ALA   A 1 427 ? -13.267 -31.655 -10.849 1.00 87.46  ? 448 ALA   A C   1 
ATOM   3083 O  O   . ALA   A 1 427 ? -13.986 -32.549 -11.310 1.00 89.92  ? 448 ALA   A O   1 
ATOM   3084 C  CB  . ALA   A 1 427 ? -14.286 -29.498 -10.071 1.00 82.93  ? 448 ALA   A CB  1 
ATOM   3085 N  N   . LEU   A 1 428 ? -12.080 -31.350 -11.380 1.00 88.71  ? 449 LEU   A N   1 
ATOM   3086 C  CA  . LEU   A 1 428 ? -11.553 -32.123 -12.499 1.00 88.37  ? 449 LEU   A CA  1 
ATOM   3087 C  C   . LEU   A 1 428 ? -11.306 -33.571 -12.099 1.00 89.69  ? 449 LEU   A C   1 
ATOM   3088 O  O   . LEU   A 1 428 ? -11.608 -34.495 -12.864 1.00 89.81  ? 449 LEU   A O   1 
ATOM   3089 C  CB  . LEU   A 1 428 ? -10.268 -31.481 -13.022 1.00 87.01  ? 449 LEU   A CB  1 
ATOM   3090 C  CG  . LEU   A 1 428 ? -10.426 -30.130 -13.722 1.00 85.34  ? 449 LEU   A CG  1 
ATOM   3091 C  CD1 . LEU   A 1 428 ? -9.066  -29.544 -14.068 1.00 88.80  ? 449 LEU   A CD1 1 
ATOM   3092 C  CD2 . LEU   A 1 428 ? -11.286 -30.273 -14.969 1.00 84.42  ? 449 LEU   A CD2 1 
ATOM   3093 N  N   . MET   A 1 429 ? -10.758 -33.791 -10.902 1.00 90.29  ? 450 MET   A N   1 
ATOM   3094 C  CA  . MET   A 1 429 ? -10.561 -35.153 -10.421 1.00 91.03  ? 450 MET   A CA  1 
ATOM   3095 C  C   . MET   A 1 429 ? -11.892 -35.873 -10.249 1.00 92.78  ? 450 MET   A C   1 
ATOM   3096 O  O   . MET   A 1 429 ? -12.028 -37.043 -10.626 1.00 93.98  ? 450 MET   A O   1 
ATOM   3097 C  CB  . MET   A 1 429 ? -9.798  -35.136 -9.097  1.00 94.14  ? 450 MET   A CB  1 
ATOM   3098 C  CG  . MET   A 1 429 ? -9.373  -36.510 -8.614  1.00 98.37  ? 450 MET   A CG  1 
ATOM   3099 S  SD  . MET   A 1 429 ? -7.798  -37.009 -9.334  1.00 104.51 ? 450 MET   A SD  1 
ATOM   3100 C  CE  . MET   A 1 429 ? -8.078  -38.757 -9.588  1.00 107.35 ? 450 MET   A CE  1 
ATOM   3101 N  N   . ASN   A 1 430 ? -12.885 -35.187 -9.680  1.00 94.05  ? 451 ASN   A N   1 
ATOM   3102 C  CA  . ASN   A 1 430 ? -14.165 -35.826 -9.391  1.00 94.55  ? 451 ASN   A CA  1 
ATOM   3103 C  C   . ASN   A 1 430 ? -14.876 -36.245 -10.672 1.00 92.66  ? 451 ASN   A C   1 
ATOM   3104 O  O   . ASN   A 1 430 ? -15.389 -37.365 -10.773 1.00 97.10  ? 451 ASN   A O   1 
ATOM   3105 C  CB  . ASN   A 1 430 ? -15.043 -34.880 -8.570  1.00 96.32  ? 451 ASN   A CB  1 
ATOM   3106 C  CG  . ASN   A 1 430 ? -16.344 -35.523 -8.133  1.00 101.45 ? 451 ASN   A CG  1 
ATOM   3107 O  OD1 . ASN   A 1 430 ? -16.440 -36.745 -8.022  1.00 107.16 ? 451 ASN   A OD1 1 
ATOM   3108 N  ND2 . ASN   A 1 430 ? -17.355 -34.699 -7.881  1.00 101.09 ? 451 ASN   A ND2 1 
ATOM   3109 N  N   . MET   A 1 431 ? -14.915 -35.353 -11.666 1.00 92.17  ? 452 MET   A N   1 
ATOM   3110 C  CA  . MET   A 1 431 ? -15.576 -35.679 -12.925 1.00 94.75  ? 452 MET   A CA  1 
ATOM   3111 C  C   . MET   A 1 431 ? -14.836 -36.781 -13.674 1.00 94.12  ? 452 MET   A C   1 
ATOM   3112 O  O   . MET   A 1 431 ? -15.464 -37.682 -14.241 1.00 94.22  ? 452 MET   A O   1 
ATOM   3113 C  CB  . MET   A 1 431 ? -15.698 -34.427 -13.794 1.00 90.40  ? 452 MET   A CB  1 
ATOM   3114 C  CG  . MET   A 1 431 ? -16.519 -33.314 -13.165 1.00 87.30  ? 452 MET   A CG  1 
ATOM   3115 S  SD  . MET   A 1 431 ? -16.759 -31.923 -14.284 1.00 89.76  ? 452 MET   A SD  1 
ATOM   3116 C  CE  . MET   A 1 431 ? -15.062 -31.515 -14.690 1.00 88.84  ? 452 MET   A CE  1 
ATOM   3117 N  N   . LYS   A 1 432 ? -13.502 -36.723 -13.691 1.00 93.07  ? 453 LYS   A N   1 
ATOM   3118 C  CA  . LYS   A 1 432 ? -12.730 -37.723 -14.423 1.00 93.39  ? 453 LYS   A CA  1 
ATOM   3119 C  C   . LYS   A 1 432 ? -12.857 -39.103 -13.788 1.00 97.06  ? 453 LYS   A C   1 
ATOM   3120 O  O   . LYS   A 1 432 ? -13.012 -40.103 -14.498 1.00 97.30  ? 453 LYS   A O   1 
ATOM   3121 C  CB  . LYS   A 1 432 ? -11.267 -37.296 -14.510 1.00 91.19  ? 453 LYS   A CB  1 
ATOM   3122 C  CG  . LYS   A 1 432 ? -11.013 -36.183 -15.515 1.00 88.94  ? 453 LYS   A CG  1 
ATOM   3123 C  CD  . LYS   A 1 432 ? -9.538  -35.828 -15.593 1.00 90.54  ? 453 LYS   A CD  1 
ATOM   3124 C  CE  . LYS   A 1 432 ? -9.278  -34.798 -16.679 1.00 88.72  ? 453 LYS   A CE  1 
ATOM   3125 N  NZ  . LYS   A 1 432 ? -7.836  -34.440 -16.770 1.00 84.27  ? 453 LYS   A NZ  1 
ATOM   3126 N  N   . LEU   A 1 433 ? -12.796 -39.179 -12.455 1.00 97.63  ? 454 LEU   A N   1 
ATOM   3127 C  CA  . LEU   A 1 433 ? -13.014 -40.458 -11.785 1.00 98.39  ? 454 LEU   A CA  1 
ATOM   3128 C  C   . LEU   A 1 433 ? -14.410 -40.997 -12.062 1.00 100.93 ? 454 LEU   A C   1 
ATOM   3129 O  O   . LEU   A 1 433 ? -14.605 -42.217 -12.124 1.00 102.92 ? 454 LEU   A O   1 
ATOM   3130 C  CB  . LEU   A 1 433 ? -12.788 -40.313 -10.280 1.00 97.29  ? 454 LEU   A CB  1 
ATOM   3131 C  CG  . LEU   A 1 433 ? -11.336 -40.293 -9.801  1.00 100.97 ? 454 LEU   A CG  1 
ATOM   3132 C  CD1 . LEU   A 1 433 ? -11.260 -40.065 -8.299  1.00 105.23 ? 454 LEU   A CD1 1 
ATOM   3133 C  CD2 . LEU   A 1 433 ? -10.636 -41.587 -10.176 1.00 105.38 ? 454 LEU   A CD2 1 
ATOM   3134 N  N   . ALA   A 1 434 ? -15.390 -40.108 -12.228 1.00 100.17 ? 455 ALA   A N   1 
ATOM   3135 C  CA  . ALA   A 1 434 ? -16.734 -40.539 -12.597 1.00 101.02 ? 455 ALA   A CA  1 
ATOM   3136 C  C   . ALA   A 1 434 ? -16.768 -41.073 -14.023 1.00 103.87 ? 455 ALA   A C   1 
ATOM   3137 O  O   . ALA   A 1 434 ? -17.351 -42.130 -14.289 1.00 109.48 ? 455 ALA   A O   1 
ATOM   3138 C  CB  . ALA   A 1 434 ? -17.717 -39.380 -12.436 1.00 100.72 ? 455 ALA   A CB  1 
ATOM   3139 N  N   . LEU   A 1 435 ? -16.141 -40.351 -14.955 1.00 100.88 ? 456 LEU   A N   1 
ATOM   3140 C  CA  . LEU   A 1 435 ? -16.185 -40.744 -16.360 1.00 101.14 ? 456 LEU   A CA  1 
ATOM   3141 C  C   . LEU   A 1 435 ? -15.482 -42.076 -16.591 1.00 104.25 ? 456 LEU   A C   1 
ATOM   3142 O  O   . LEU   A 1 435 ? -15.930 -42.884 -17.412 1.00 106.87 ? 456 LEU   A O   1 
ATOM   3143 C  CB  . LEU   A 1 435 ? -15.563 -39.652 -17.228 1.00 98.43  ? 456 LEU   A CB  1 
ATOM   3144 C  CG  . LEU   A 1 435 ? -16.368 -38.357 -17.357 1.00 94.28  ? 456 LEU   A CG  1 
ATOM   3145 C  CD1 . LEU   A 1 435 ? -15.533 -37.263 -18.003 1.00 91.35  ? 456 LEU   A CD1 1 
ATOM   3146 C  CD2 . LEU   A 1 435 ? -17.641 -38.600 -18.153 1.00 95.88  ? 456 LEU   A CD2 1 
ATOM   3147 N  N   . ILE   A 1 436 ? -14.377 -42.319 -15.884 1.00 103.52 ? 457 ILE   A N   1 
ATOM   3148 C  CA  . ILE   A 1 436 ? -13.612 -43.545 -16.097 1.00 105.90 ? 457 ILE   A CA  1 
ATOM   3149 C  C   . ILE   A 1 436 ? -14.435 -44.767 -15.707 1.00 108.40 ? 457 ILE   A C   1 
ATOM   3150 O  O   . ILE   A 1 436 ? -14.559 -45.725 -16.479 1.00 109.62 ? 457 ILE   A O   1 
ATOM   3151 C  CB  . ILE   A 1 436 ? -12.284 -43.487 -15.322 1.00 108.70 ? 457 ILE   A CB  1 
ATOM   3152 C  CG1 . ILE   A 1 436 ? -11.374 -42.412 -15.918 1.00 104.77 ? 457 ILE   A CG1 1 
ATOM   3153 C  CG2 . ILE   A 1 436 ? -11.601 -44.842 -15.334 1.00 110.86 ? 457 ILE   A CG2 1 
ATOM   3154 C  CD1 . ILE   A 1 436 ? -10.206 -42.056 -15.043 1.00 100.66 ? 457 ILE   A CD1 1 
ATOM   3155 N  N   . ARG   A 1 437 ? -15.018 -44.748 -14.505 1.00 110.49 ? 458 ARG   A N   1 
ATOM   3156 C  CA  . ARG   A 1 437 ? -15.800 -45.894 -14.047 1.00 112.58 ? 458 ARG   A CA  1 
ATOM   3157 C  C   . ARG   A 1 437 ? -17.038 -46.101 -14.910 1.00 111.58 ? 458 ARG   A C   1 
ATOM   3158 O  O   . ARG   A 1 437 ? -17.399 -47.241 -15.225 1.00 113.20 ? 458 ARG   A O   1 
ATOM   3159 C  CB  . ARG   A 1 437 ? -16.195 -45.712 -12.581 1.00 112.81 ? 458 ARG   A CB  1 
ATOM   3160 C  CG  . ARG   A 1 437 ? -15.022 -45.747 -11.621 1.00 114.81 ? 458 ARG   A CG  1 
ATOM   3161 C  CD  . ARG   A 1 437 ? -14.266 -47.058 -11.731 1.00 116.86 ? 458 ARG   A CD  1 
ATOM   3162 N  NE  . ARG   A 1 437 ? -15.024 -48.188 -11.210 1.00 121.25 ? 458 ARG   A NE  1 
ATOM   3163 C  CZ  . ARG   A 1 437 ? -15.006 -48.580 -9.943  1.00 122.46 ? 458 ARG   A CZ  1 
ATOM   3164 N  NH1 . ARG   A 1 437 ? -14.295 -47.938 -9.031  1.00 119.13 ? 458 ARG   A NH1 1 
ATOM   3165 N  NH2 . ARG   A 1 437 ? -15.719 -49.643 -9.582  1.00 123.53 ? 458 ARG   A NH2 1 
ATOM   3166 N  N   . VAL   A 1 438 ? -17.703 -45.011 -15.294 1.00 108.94 ? 459 VAL   A N   1 
ATOM   3167 C  CA  . VAL   A 1 438 ? -18.899 -45.121 -16.122 1.00 110.74 ? 459 VAL   A CA  1 
ATOM   3168 C  C   . VAL   A 1 438 ? -18.550 -45.652 -17.509 1.00 109.61 ? 459 VAL   A C   1 
ATOM   3169 O  O   . VAL   A 1 438 ? -19.242 -46.526 -18.045 1.00 112.89 ? 459 VAL   A O   1 
ATOM   3170 C  CB  . VAL   A 1 438 ? -19.617 -43.761 -16.189 1.00 108.64 ? 459 VAL   A CB  1 
ATOM   3171 C  CG1 . VAL   A 1 438 ? -20.591 -43.725 -17.346 1.00 105.68 ? 459 VAL   A CG1 1 
ATOM   3172 C  CG2 . VAL   A 1 438 ? -20.341 -43.488 -14.880 1.00 107.25 ? 459 VAL   A CG2 1 
ATOM   3173 N  N   . LEU   A 1 439 ? -17.472 -45.143 -18.109 1.00 107.82 ? 460 LEU   A N   1 
ATOM   3174 C  CA  . LEU   A 1 439 ? -17.073 -45.596 -19.437 1.00 108.88 ? 460 LEU   A CA  1 
ATOM   3175 C  C   . LEU   A 1 439 ? -16.383 -46.954 -19.420 1.00 111.52 ? 460 LEU   A C   1 
ATOM   3176 O  O   . LEU   A 1 439 ? -16.308 -47.605 -20.469 1.00 109.81 ? 460 LEU   A O   1 
ATOM   3177 C  CB  . LEU   A 1 439 ? -16.161 -44.560 -20.096 1.00 103.06 ? 460 LEU   A CB  1 
ATOM   3178 C  CG  . LEU   A 1 439 ? -16.887 -43.333 -20.645 1.00 99.89  ? 460 LEU   A CG  1 
ATOM   3179 C  CD1 . LEU   A 1 439 ? -15.907 -42.209 -20.912 1.00 101.53 ? 460 LEU   A CD1 1 
ATOM   3180 C  CD2 . LEU   A 1 439 ? -17.645 -43.694 -21.913 1.00 99.59  ? 460 LEU   A CD2 1 
ATOM   3181 N  N   . GLN   A 1 440 ? -15.871 -47.393 -18.267 1.00 111.51 ? 461 GLN   A N   1 
ATOM   3182 C  CA  . GLN   A 1 440 ? -15.326 -48.741 -18.166 1.00 111.35 ? 461 GLN   A CA  1 
ATOM   3183 C  C   . GLN   A 1 440 ? -16.403 -49.809 -18.288 1.00 112.99 ? 461 GLN   A C   1 
ATOM   3184 O  O   . GLN   A 1 440 ? -16.086 -50.955 -18.623 1.00 116.28 ? 461 GLN   A O   1 
ATOM   3185 C  CB  . GLN   A 1 440 ? -14.586 -48.926 -16.839 1.00 110.54 ? 461 GLN   A CB  1 
ATOM   3186 C  CG  . GLN   A 1 440 ? -13.119 -48.530 -16.861 1.00 112.07 ? 461 GLN   A CG  1 
ATOM   3187 C  CD  . GLN   A 1 440 ? -12.455 -48.705 -15.508 1.00 114.94 ? 461 GLN   A CD  1 
ATOM   3188 O  OE1 . GLN   A 1 440 ? -13.120 -48.696 -14.472 1.00 111.49 ? 461 GLN   A OE1 1 
ATOM   3189 N  NE2 . GLN   A 1 440 ? -11.137 -48.872 -15.512 1.00 118.08 ? 461 GLN   A NE2 1 
ATOM   3190 N  N   . ASN   A 1 441 ? -17.662 -49.462 -18.024 1.00 113.58 ? 462 ASN   A N   1 
ATOM   3191 C  CA  . ASN   A 1 441 ? -18.732 -50.442 -17.954 1.00 114.27 ? 462 ASN   A CA  1 
ATOM   3192 C  C   . ASN   A 1 441 ? -19.905 -50.156 -18.879 1.00 111.84 ? 462 ASN   A C   1 
ATOM   3193 O  O   . ASN   A 1 441 ? -20.733 -51.050 -19.083 1.00 114.34 ? 462 ASN   A O   1 
ATOM   3194 C  CB  . ASN   A 1 441 ? -19.259 -50.549 -16.513 1.00 114.66 ? 462 ASN   A CB  1 
ATOM   3195 C  CG  . ASN   A 1 441 ? -18.180 -50.954 -15.527 1.00 118.58 ? 462 ASN   A CG  1 
ATOM   3196 O  OD1 . ASN   A 1 441 ? -18.032 -52.132 -15.201 1.00 123.02 ? 462 ASN   A OD1 1 
ATOM   3197 N  ND2 . ASN   A 1 441 ? -17.419 -49.977 -15.046 1.00 116.82 ? 462 ASN   A ND2 1 
ATOM   3198 N  N   . PHE   A 1 442 ? -20.007 -48.954 -19.441 1.00 110.00 ? 463 PHE   A N   1 
ATOM   3199 C  CA  . PHE   A 1 442 ? -21.169 -48.593 -20.238 1.00 109.42 ? 463 PHE   A CA  1 
ATOM   3200 C  C   . PHE   A 1 442 ? -20.749 -47.780 -21.452 1.00 106.30 ? 463 PHE   A C   1 
ATOM   3201 O  O   . PHE   A 1 442 ? -19.724 -47.093 -21.442 1.00 106.15 ? 463 PHE   A O   1 
ATOM   3202 C  CB  . PHE   A 1 442 ? -22.190 -47.795 -19.418 1.00 110.08 ? 463 PHE   A CB  1 
ATOM   3203 C  CG  . PHE   A 1 442 ? -22.703 -48.526 -18.211 1.00 113.47 ? 463 PHE   A CG  1 
ATOM   3204 C  CD1 . PHE   A 1 442 ? -23.614 -49.560 -18.347 1.00 113.79 ? 463 PHE   A CD1 1 
ATOM   3205 C  CD2 . PHE   A 1 442 ? -22.279 -48.173 -16.940 1.00 114.21 ? 463 PHE   A CD2 1 
ATOM   3206 C  CE1 . PHE   A 1 442 ? -24.089 -50.232 -17.239 1.00 116.30 ? 463 PHE   A CE1 1 
ATOM   3207 C  CE2 . PHE   A 1 442 ? -22.751 -48.841 -15.828 1.00 115.47 ? 463 PHE   A CE2 1 
ATOM   3208 C  CZ  . PHE   A 1 442 ? -23.656 -49.872 -15.978 1.00 117.53 ? 463 PHE   A CZ  1 
ATOM   3209 N  N   . SER   A 1 443 ? -21.563 -47.869 -22.500 1.00 103.65 ? 464 SER   A N   1 
ATOM   3210 C  CA  . SER   A 1 443 ? -21.451 -47.028 -23.681 1.00 101.72 ? 464 SER   A CA  1 
ATOM   3211 C  C   . SER   A 1 443 ? -22.788 -46.335 -23.903 1.00 102.47 ? 464 SER   A C   1 
ATOM   3212 O  O   . SER   A 1 443 ? -23.849 -46.932 -23.692 1.00 104.25 ? 464 SER   A O   1 
ATOM   3213 C  CB  . SER   A 1 443 ? -21.060 -47.844 -24.917 1.00 103.86 ? 464 SER   A CB  1 
ATOM   3214 O  OG  . SER   A 1 443 ? -20.677 -46.994 -25.984 1.00 103.72 ? 464 SER   A OG  1 
ATOM   3215 N  N   . PHE   A 1 444 ? -22.736 -45.075 -24.323 1.00 99.98  ? 465 PHE   A N   1 
ATOM   3216 C  CA  . PHE   A 1 444 ? -23.914 -44.219 -24.373 1.00 99.19  ? 465 PHE   A CA  1 
ATOM   3217 C  C   . PHE   A 1 444 ? -24.230 -43.848 -25.813 1.00 101.77 ? 465 PHE   A C   1 
ATOM   3218 O  O   . PHE   A 1 444 ? -23.351 -43.392 -26.552 1.00 100.60 ? 465 PHE   A O   1 
ATOM   3219 C  CB  . PHE   A 1 444 ? -23.708 -42.964 -23.522 1.00 99.85  ? 465 PHE   A CB  1 
ATOM   3220 C  CG  . PHE   A 1 444 ? -23.649 -43.242 -22.047 1.00 101.43 ? 465 PHE   A CG  1 
ATOM   3221 C  CD1 . PHE   A 1 444 ? -22.563 -43.902 -21.497 1.00 101.09 ? 465 PHE   A CD1 1 
ATOM   3222 C  CD2 . PHE   A 1 444 ? -24.683 -42.853 -21.212 1.00 100.80 ? 465 PHE   A CD2 1 
ATOM   3223 C  CE1 . PHE   A 1 444 ? -22.507 -44.166 -20.148 1.00 102.23 ? 465 PHE   A CE1 1 
ATOM   3224 C  CE2 . PHE   A 1 444 ? -24.630 -43.114 -19.856 1.00 98.95  ? 465 PHE   A CE2 1 
ATOM   3225 C  CZ  . PHE   A 1 444 ? -23.541 -43.771 -19.324 1.00 99.93  ? 465 PHE   A CZ  1 
ATOM   3226 N  N   . LYS   A 1 445 ? -25.485 -44.039 -26.199 1.00 104.44 ? 466 LYS   A N   1 
ATOM   3227 C  CA  . LYS   A 1 445 ? -25.973 -43.766 -27.538 1.00 104.76 ? 466 LYS   A CA  1 
ATOM   3228 C  C   . LYS   A 1 445 ? -27.183 -42.850 -27.461 1.00 105.48 ? 466 LYS   A C   1 
ATOM   3229 O  O   . LYS   A 1 445 ? -27.872 -42.809 -26.435 1.00 105.93 ? 466 LYS   A O   1 
ATOM   3230 C  CB  . LYS   A 1 445 ? -26.354 -45.065 -28.265 1.00 101.77 ? 466 LYS   A CB  1 
ATOM   3231 N  N   . PRO   A 1 446 ? -27.458 -42.092 -28.522 1.00 104.78 ? 467 PRO   A N   1 
ATOM   3232 C  CA  . PRO   A 1 446 ? -28.638 -41.224 -28.519 1.00 107.54 ? 467 PRO   A CA  1 
ATOM   3233 C  C   . PRO   A 1 446 ? -29.922 -42.024 -28.355 1.00 111.18 ? 467 PRO   A C   1 
ATOM   3234 O  O   . PRO   A 1 446 ? -30.001 -43.210 -28.681 1.00 111.74 ? 467 PRO   A O   1 
ATOM   3235 C  CB  . PRO   A 1 446 ? -28.580 -40.537 -29.889 1.00 105.85 ? 467 PRO   A CB  1 
ATOM   3236 C  CG  . PRO   A 1 446 ? -27.138 -40.572 -30.258 1.00 101.86 ? 467 PRO   A CG  1 
ATOM   3237 C  CD  . PRO   A 1 446 ? -26.610 -41.864 -29.705 1.00 103.05 ? 467 PRO   A CD  1 
ATOM   3238 N  N   . CYS   A 1 447 ? -30.936 -41.349 -27.833 1.00 115.68 ? 468 CYS   A N   1 
ATOM   3239 C  CA  . CYS   A 1 447 ? -32.222 -41.950 -27.518 1.00 116.19 ? 468 CYS   A CA  1 
ATOM   3240 C  C   . CYS   A 1 447 ? -33.316 -41.188 -28.266 1.00 116.28 ? 468 CYS   A C   1 
ATOM   3241 O  O   . CYS   A 1 447 ? -33.039 -40.382 -29.159 1.00 115.96 ? 468 CYS   A O   1 
ATOM   3242 C  CB  . CYS   A 1 447 ? -32.451 -41.956 -26.005 1.00 115.99 ? 468 CYS   A CB  1 
ATOM   3243 S  SG  . CYS   A 1 447 ? -33.804 -43.014 -25.457 1.00 124.30 ? 468 CYS   A SG  1 
ATOM   3244 N  N   . LYS   A 1 448 ? -34.570 -41.470 -27.910 1.00 118.73 ? 469 LYS   A N   1 
ATOM   3245 C  CA  . LYS   A 1 448 ? -35.697 -40.834 -28.587 1.00 121.15 ? 469 LYS   A CA  1 
ATOM   3246 C  C   . LYS   A 1 448 ? -35.637 -39.316 -28.452 1.00 120.51 ? 469 LYS   A C   1 
ATOM   3247 O  O   . LYS   A 1 448 ? -35.543 -38.593 -29.450 1.00 118.07 ? 469 LYS   A O   1 
ATOM   3248 C  CB  . LYS   A 1 448 ? -37.017 -41.378 -28.037 1.00 121.54 ? 469 LYS   A CB  1 
ATOM   3249 C  CG  . LYS   A 1 448 ? -37.501 -42.661 -28.704 1.00 117.95 ? 469 LYS   A CG  1 
ATOM   3250 C  CD  . LYS   A 1 448 ? -36.671 -43.869 -28.298 1.00 114.10 ? 469 LYS   A CD  1 
ATOM   3251 C  CE  . LYS   A 1 448 ? -36.868 -44.210 -26.829 1.00 116.59 ? 469 LYS   A CE  1 
ATOM   3252 N  NZ  . LYS   A 1 448 ? -36.034 -45.372 -26.408 1.00 119.95 ? 469 LYS   A NZ  1 
ATOM   3253 N  N   . GLU   A 1 449 ? -35.691 -38.813 -27.222 1.00 123.90 ? 470 GLU   A N   1 
ATOM   3254 C  CA  . GLU   A 1 449 ? -35.661 -37.369 -26.982 1.00 124.36 ? 470 GLU   A CA  1 
ATOM   3255 C  C   . GLU   A 1 449 ? -34.243 -36.866 -26.707 1.00 120.63 ? 470 GLU   A C   1 
ATOM   3256 O  O   . GLU   A 1 449 ? -33.987 -36.138 -25.747 1.00 118.12 ? 470 GLU   A O   1 
ATOM   3257 C  CB  . GLU   A 1 449 ? -36.610 -37.011 -25.841 1.00 124.44 ? 470 GLU   A CB  1 
ATOM   3258 C  CG  . GLU   A 1 449 ? -36.262 -37.600 -24.472 1.00 125.11 ? 470 GLU   A CG  1 
ATOM   3259 C  CD  . GLU   A 1 449 ? -36.612 -39.068 -24.336 1.00 126.74 ? 470 GLU   A CD  1 
ATOM   3260 O  OE1 . GLU   A 1 449 ? -37.080 -39.670 -25.325 1.00 127.16 ? 470 GLU   A OE1 1 
ATOM   3261 O  OE2 . GLU   A 1 449 ? -36.421 -39.622 -23.233 1.00 125.30 ? 470 GLU   A OE2 1 
ATOM   3262 N  N   . THR   A 1 450 ? -33.304 -37.226 -27.584 1.00 118.30 ? 471 THR   A N   1 
ATOM   3263 C  CA  . THR   A 1 450 ? -31.932 -36.758 -27.416 1.00 118.23 ? 471 THR   A CA  1 
ATOM   3264 C  C   . THR   A 1 450 ? -31.815 -35.262 -27.682 1.00 120.51 ? 471 THR   A C   1 
ATOM   3265 O  O   . THR   A 1 450 ? -30.933 -34.603 -27.117 1.00 118.95 ? 471 THR   A O   1 
ATOM   3266 C  CB  . THR   A 1 450 ? -30.987 -37.540 -28.333 1.00 117.26 ? 471 THR   A CB  1 
ATOM   3267 O  OG1 . THR   A 1 450 ? -31.151 -38.944 -28.105 1.00 120.71 ? 471 THR   A OG1 1 
ATOM   3268 C  CG2 . THR   A 1 450 ? -29.532 -37.171 -28.059 1.00 113.70 ? 471 THR   A CG2 1 
ATOM   3269 N  N   . GLN   A 1 451 ? -32.701 -34.706 -28.513 1.00 118.52 ? 472 GLN   A N   1 
ATOM   3270 C  CA  . GLN   A 1 451 ? -32.655 -33.294 -28.897 1.00 116.66 ? 472 GLN   A CA  1 
ATOM   3271 C  C   . GLN   A 1 451 ? -31.308 -32.966 -29.549 1.00 115.06 ? 472 GLN   A C   1 
ATOM   3272 O  O   . GLN   A 1 451 ? -30.471 -32.240 -29.007 1.00 112.52 ? 472 GLN   A O   1 
ATOM   3273 C  CB  . GLN   A 1 451 ? -32.937 -32.383 -27.695 1.00 114.47 ? 472 GLN   A CB  1 
ATOM   3274 C  CG  . GLN   A 1 451 ? -33.168 -30.922 -28.054 1.00 114.25 ? 472 GLN   A CG  1 
ATOM   3275 C  CD  . GLN   A 1 451 ? -33.401 -30.055 -26.833 1.00 115.68 ? 472 GLN   A CD  1 
ATOM   3276 O  OE1 . GLN   A 1 451 ? -33.501 -30.557 -25.713 1.00 117.14 ? 472 GLN   A OE1 1 
ATOM   3277 N  NE2 . GLN   A 1 451 ? -33.485 -28.746 -27.041 1.00 114.39 ? 472 GLN   A NE2 1 
ATOM   3278 N  N   . ILE   A 1 452 ? -31.118 -33.569 -30.730 1.00 117.02 ? 473 ILE   A N   1 
ATOM   3279 C  CA  . ILE   A 1 452 ? -29.840 -33.455 -31.437 1.00 115.19 ? 473 ILE   A CA  1 
ATOM   3280 C  C   . ILE   A 1 452 ? -29.373 -32.008 -31.565 1.00 117.28 ? 473 ILE   A C   1 
ATOM   3281 O  O   . ILE   A 1 452 ? -28.195 -31.739 -31.293 1.00 117.71 ? 473 ILE   A O   1 
ATOM   3282 C  CB  . ILE   A 1 452 ? -29.922 -34.180 -32.793 1.00 114.68 ? 473 ILE   A CB  1 
ATOM   3283 C  CG1 . ILE   A 1 452 ? -30.070 -35.687 -32.580 1.00 112.21 ? 473 ILE   A CG1 1 
ATOM   3284 C  CG2 . ILE   A 1 452 ? -28.703 -33.866 -33.646 1.00 119.12 ? 473 ILE   A CG2 1 
ATOM   3285 C  CD1 . ILE   A 1 452 ? -28.912 -36.314 -31.836 1.00 108.51 ? 473 ILE   A CD1 1 
ATOM   3286 N  N   . PRO   A 1 453 ? -30.217 -31.039 -31.952 1.00 118.08 ? 474 PRO   A N   1 
ATOM   3287 C  CA  . PRO   A 1 453 ? -29.770 -29.640 -31.788 1.00 114.75 ? 474 PRO   A CA  1 
ATOM   3288 C  C   . PRO   A 1 453 ? -29.970 -29.178 -30.346 1.00 115.09 ? 474 PRO   A C   1 
ATOM   3289 O  O   . PRO   A 1 453 ? -30.963 -28.549 -29.978 1.00 117.00 ? 474 PRO   A O   1 
ATOM   3290 C  CB  . PRO   A 1 453 ? -30.660 -28.885 -32.778 1.00 115.54 ? 474 PRO   A CB  1 
ATOM   3291 C  CG  . PRO   A 1 453 ? -31.919 -29.674 -32.807 1.00 116.26 ? 474 PRO   A CG  1 
ATOM   3292 C  CD  . PRO   A 1 453 ? -31.512 -31.118 -32.655 1.00 117.59 ? 474 PRO   A CD  1 
ATOM   3293 N  N   . LEU   A 1 454 ? -29.001 -29.518 -29.496 1.00 111.45 ? 475 LEU   A N   1 
ATOM   3294 C  CA  . LEU   A 1 454 ? -29.098 -29.201 -28.075 1.00 109.04 ? 475 LEU   A CA  1 
ATOM   3295 C  C   . LEU   A 1 454 ? -29.201 -27.697 -27.872 1.00 107.23 ? 475 LEU   A C   1 
ATOM   3296 O  O   . LEU   A 1 454 ? -28.275 -26.949 -28.201 1.00 106.67 ? 475 LEU   A O   1 
ATOM   3297 C  CB  . LEU   A 1 454 ? -27.891 -29.758 -27.320 1.00 106.73 ? 475 LEU   A CB  1 
ATOM   3298 C  CG  . LEU   A 1 454 ? -27.859 -29.439 -25.821 1.00 104.69 ? 475 LEU   A CG  1 
ATOM   3299 C  CD1 . LEU   A 1 454 ? -27.616 -30.696 -24.998 1.00 102.68 ? 475 LEU   A CD1 1 
ATOM   3300 C  CD2 . LEU   A 1 454 ? -26.810 -28.380 -25.506 1.00 101.40 ? 475 LEU   A CD2 1 
ATOM   3301 N  N   . LYS   A 1 455 ? -30.329 -27.257 -27.325 1.00 108.32 ? 476 LYS   A N   1 
ATOM   3302 C  CA  . LYS   A 1 455 ? -30.600 -25.843 -27.115 1.00 111.04 ? 476 LYS   A CA  1 
ATOM   3303 C  C   . LYS   A 1 455 ? -30.254 -25.463 -25.683 1.00 108.64 ? 476 LYS   A C   1 
ATOM   3304 O  O   . LYS   A 1 455 ? -30.615 -26.176 -24.741 1.00 107.31 ? 476 LYS   A O   1 
ATOM   3305 C  CB  . LYS   A 1 455 ? -32.066 -25.520 -27.408 1.00 112.97 ? 476 LYS   A CB  1 
ATOM   3306 C  CG  . LYS   A 1 455 ? -32.517 -25.883 -28.812 1.00 112.98 ? 476 LYS   A CG  1 
ATOM   3307 C  CD  . LYS   A 1 455 ? -31.615 -25.253 -29.860 1.00 111.27 ? 476 LYS   A CD  1 
ATOM   3308 C  CE  . LYS   A 1 455 ? -32.193 -25.409 -31.256 1.00 104.25 ? 476 LYS   A CE  1 
ATOM   3309 N  NZ  . LYS   A 1 455 ? -33.473 -24.663 -31.409 1.00 101.87 ? 476 LYS   A NZ  1 
ATOM   3310 N  N   . LEU   A 1 456 ? -29.545 -24.349 -25.527 1.00 106.44 ? 477 LEU   A N   1 
ATOM   3311 C  CA  . LEU   A 1 456 ? -29.199 -23.850 -24.205 1.00 106.96 ? 477 LEU   A CA  1 
ATOM   3312 C  C   . LEU   A 1 456 ? -30.365 -23.074 -23.609 1.00 108.03 ? 477 LEU   A C   1 
ATOM   3313 O  O   . LEU   A 1 456 ? -31.067 -22.341 -24.312 1.00 106.93 ? 477 LEU   A O   1 
ATOM   3314 C  CB  . LEU   A 1 456 ? -27.956 -22.964 -24.279 1.00 105.13 ? 477 LEU   A CB  1 
ATOM   3315 C  CG  . LEU   A 1 456 ? -26.647 -23.693 -24.585 1.00 100.49 ? 477 LEU   A CG  1 
ATOM   3316 C  CD1 . LEU   A 1 456 ? -25.514 -22.704 -24.799 1.00 98.10  ? 477 LEU   A CD1 1 
ATOM   3317 C  CD2 . LEU   A 1 456 ? -26.308 -24.667 -23.467 1.00 97.44  ? 477 LEU   A CD2 1 
ATOM   3318 N  N   . SER   A 1 457 ? -30.573 -23.248 -22.305 1.00 109.69 ? 478 SER   A N   1 
ATOM   3319 C  CA  . SER   A 1 457 ? -31.633 -22.526 -21.613 1.00 107.93 ? 478 SER   A CA  1 
ATOM   3320 C  C   . SER   A 1 457 ? -31.391 -21.025 -21.695 1.00 107.46 ? 478 SER   A C   1 
ATOM   3321 O  O   . SER   A 1 457 ? -30.286 -20.545 -21.423 1.00 109.24 ? 478 SER   A O   1 
ATOM   3322 C  CB  . SER   A 1 457 ? -31.711 -22.971 -20.153 1.00 105.90 ? 478 SER   A CB  1 
ATOM   3323 O  OG  . SER   A 1 457 ? -32.465 -22.053 -19.383 1.00 103.07 ? 478 SER   A OG  1 
ATOM   3324 N  N   . LEU   A 1 458 ? -32.432 -20.284 -22.067 1.00 108.32 ? 479 LEU   A N   1 
ATOM   3325 C  CA  . LEU   A 1 458 ? -32.343 -18.836 -22.205 1.00 106.35 ? 479 LEU   A CA  1 
ATOM   3326 C  C   . LEU   A 1 458 ? -32.361 -18.111 -20.864 1.00 106.56 ? 479 LEU   A C   1 
ATOM   3327 O  O   . LEU   A 1 458 ? -32.465 -16.882 -20.844 1.00 109.80 ? 479 LEU   A O   1 
ATOM   3328 C  CB  . LEU   A 1 458 ? -33.484 -18.320 -23.087 1.00 105.63 ? 479 LEU   A CB  1 
ATOM   3329 C  CG  . LEU   A 1 458 ? -33.541 -18.882 -24.508 1.00 108.58 ? 479 LEU   A CG  1 
ATOM   3330 C  CD1 . LEU   A 1 458 ? -34.733 -18.317 -25.270 1.00 109.78 ? 479 LEU   A CD1 1 
ATOM   3331 C  CD2 . LEU   A 1 458 ? -32.242 -18.602 -25.249 1.00 103.89 ? 479 LEU   A CD2 1 
ATOM   3332 N  N   . GLY   A 1 459 ? -32.266 -18.829 -19.751 1.00 103.90 ? 480 GLY   A N   1 
ATOM   3333 C  CA  . GLY   A 1 459 ? -32.281 -18.213 -18.442 1.00 104.43 ? 480 GLY   A CA  1 
ATOM   3334 C  C   . GLY   A 1 459 ? -30.915 -17.700 -18.043 1.00 104.54 ? 480 GLY   A C   1 
ATOM   3335 O  O   . GLY   A 1 459 ? -30.055 -17.413 -18.880 1.00 102.94 ? 480 GLY   A O   1 
ATOM   3336 N  N   . GLY   A 1 460 ? -30.720 -17.576 -16.734 1.00 106.49 ? 481 GLY   A N   1 
ATOM   3337 C  CA  . GLY   A 1 460 ? -29.457 -17.149 -16.171 1.00 105.33 ? 481 GLY   A CA  1 
ATOM   3338 C  C   . GLY   A 1 460 ? -28.514 -18.276 -15.814 1.00 104.24 ? 481 GLY   A C   1 
ATOM   3339 O  O   . GLY   A 1 460 ? -27.523 -18.037 -15.113 1.00 102.70 ? 481 GLY   A O   1 
ATOM   3340 N  N   . LEU   A 1 461 ? -28.795 -19.500 -16.266 1.00 104.18 ? 482 LEU   A N   1 
ATOM   3341 C  CA  . LEU   A 1 461 ? -27.963 -20.663 -15.989 1.00 103.53 ? 482 LEU   A CA  1 
ATOM   3342 C  C   . LEU   A 1 461 ? -27.621 -21.363 -17.294 1.00 105.97 ? 482 LEU   A C   1 
ATOM   3343 O  O   . LEU   A 1 461 ? -28.449 -21.424 -18.208 1.00 106.19 ? 482 LEU   A O   1 
ATOM   3344 C  CB  . LEU   A 1 461 ? -28.673 -21.634 -15.043 1.00 102.43 ? 482 LEU   A CB  1 
ATOM   3345 C  CG  . LEU   A 1 461 ? -29.155 -21.042 -13.716 1.00 104.63 ? 482 LEU   A CG  1 
ATOM   3346 C  CD1 . LEU   A 1 461 ? -30.045 -22.020 -12.965 1.00 106.86 ? 482 LEU   A CD1 1 
ATOM   3347 C  CD2 . LEU   A 1 461 ? -27.967 -20.628 -12.865 1.00 103.97 ? 482 LEU   A CD2 1 
ATOM   3348 N  N   . LEU   A 1 462 ? -26.406 -21.905 -17.375 1.00 103.38 ? 483 LEU   A N   1 
ATOM   3349 C  CA  . LEU   A 1 462 ? -25.974 -22.618 -18.577 1.00 98.82  ? 483 LEU   A CA  1 
ATOM   3350 C  C   . LEU   A 1 462 ? -26.365 -24.081 -18.426 1.00 98.36  ? 483 LEU   A C   1 
ATOM   3351 O  O   . LEU   A 1 462 ? -25.602 -24.907 -17.925 1.00 96.56  ? 483 LEU   A O   1 
ATOM   3352 C  CB  . LEU   A 1 462 ? -24.478 -22.458 -18.814 1.00 93.19  ? 483 LEU   A CB  1 
ATOM   3353 C  CG  . LEU   A 1 462 ? -24.066 -22.930 -20.210 1.00 91.32  ? 483 LEU   A CG  1 
ATOM   3354 C  CD1 . LEU   A 1 462 ? -24.711 -22.052 -21.270 1.00 94.04  ? 483 LEU   A CD1 1 
ATOM   3355 C  CD2 . LEU   A 1 462 ? -22.563 -22.936 -20.362 1.00 88.32  ? 483 LEU   A CD2 1 
ATOM   3356 N  N   . GLN   A 1 463 ? -27.576 -24.398 -18.859 1.00 102.67 ? 484 GLN   A N   1 
ATOM   3357 C  CA  . GLN   A 1 463 ? -28.112 -25.748 -18.836 1.00 104.53 ? 484 GLN   A CA  1 
ATOM   3358 C  C   . GLN   A 1 463 ? -28.911 -25.959 -20.111 1.00 106.46 ? 484 GLN   A C   1 
ATOM   3359 O  O   . GLN   A 1 463 ? -29.383 -24.994 -20.721 1.00 106.86 ? 484 GLN   A O   1 
ATOM   3360 C  CB  . GLN   A 1 463 ? -28.992 -25.980 -17.600 1.00 102.91 ? 484 GLN   A CB  1 
ATOM   3361 C  CG  . GLN   A 1 463 ? -30.147 -25.002 -17.469 1.00 105.69 ? 484 GLN   A CG  1 
ATOM   3362 C  CD  . GLN   A 1 463 ? -30.655 -24.885 -16.044 1.00 108.95 ? 484 GLN   A CD  1 
ATOM   3363 O  OE1 . GLN   A 1 463 ? -29.890 -25.015 -15.087 1.00 108.20 ? 484 GLN   A OE1 1 
ATOM   3364 N  NE2 . GLN   A 1 463 ? -31.951 -24.637 -15.896 1.00 108.65 ? 484 GLN   A NE2 1 
ATOM   3365 N  N   . PRO   A 1 464 ? -29.061 -27.206 -20.553 1.00 106.67 ? 485 PRO   A N   1 
ATOM   3366 C  CA  . PRO   A 1 464 ? -29.854 -27.463 -21.759 1.00 107.00 ? 485 PRO   A CA  1 
ATOM   3367 C  C   . PRO   A 1 464 ? -31.315 -27.097 -21.550 1.00 108.24 ? 485 PRO   A C   1 
ATOM   3368 O  O   . PRO   A 1 464 ? -31.828 -27.108 -20.428 1.00 108.37 ? 485 PRO   A O   1 
ATOM   3369 C  CB  . PRO   A 1 464 ? -29.685 -28.970 -21.983 1.00 106.75 ? 485 PRO   A CB  1 
ATOM   3370 C  CG  . PRO   A 1 464 ? -28.435 -29.330 -21.247 1.00 103.29 ? 485 PRO   A CG  1 
ATOM   3371 C  CD  . PRO   A 1 464 ? -28.405 -28.426 -20.055 1.00 104.66 ? 485 PRO   A CD  1 
ATOM   3372 N  N   . GLU   A 1 465 ? -31.981 -26.753 -22.656 1.00 109.67 ? 486 GLU   A N   1 
ATOM   3373 C  CA  . GLU   A 1 465 ? -33.400 -26.416 -22.593 1.00 110.79 ? 486 GLU   A CA  1 
ATOM   3374 C  C   . GLU   A 1 465 ? -34.210 -27.581 -22.036 1.00 112.51 ? 486 GLU   A C   1 
ATOM   3375 O  O   . GLU   A 1 465 ? -35.080 -27.396 -21.176 1.00 114.95 ? 486 GLU   A O   1 
ATOM   3376 C  CB  . GLU   A 1 465 ? -33.907 -26.022 -23.981 1.00 110.04 ? 486 GLU   A CB  1 
ATOM   3377 C  CG  . GLU   A 1 465 ? -35.384 -25.659 -24.024 1.00 112.19 ? 486 GLU   A CG  1 
ATOM   3378 C  CD  . GLU   A 1 465 ? -35.869 -25.345 -25.427 1.00 117.46 ? 486 GLU   A CD  1 
ATOM   3379 O  OE1 . GLU   A 1 465 ? -35.084 -25.517 -26.383 1.00 116.52 ? 486 GLU   A OE1 1 
ATOM   3380 O  OE2 . GLU   A 1 465 ? -37.036 -24.926 -25.576 1.00 120.02 ? 486 GLU   A OE2 1 
ATOM   3381 N  N   . LYS   A 1 466 ? -33.930 -28.791 -22.511 1.00 108.45 ? 487 LYS   A N   1 
ATOM   3382 C  CA  . LYS   A 1 466 ? -34.518 -30.004 -21.975 1.00 108.28 ? 487 LYS   A CA  1 
ATOM   3383 C  C   . LYS   A 1 466 ? -33.418 -30.915 -21.444 1.00 108.91 ? 487 LYS   A C   1 
ATOM   3384 O  O   . LYS   A 1 466 ? -32.316 -30.947 -21.999 1.00 108.28 ? 487 LYS   A O   1 
ATOM   3385 C  CB  . LYS   A 1 466 ? -35.331 -30.749 -23.041 1.00 110.71 ? 487 LYS   A CB  1 
ATOM   3386 N  N   . PRO   A 1 467 ? -33.682 -31.656 -20.367 1.00 107.99 ? 488 PRO   A N   1 
ATOM   3387 C  CA  . PRO   A 1 467 ? -32.647 -32.534 -19.809 1.00 107.56 ? 488 PRO   A CA  1 
ATOM   3388 C  C   . PRO   A 1 467 ? -32.197 -33.576 -20.823 1.00 107.14 ? 488 PRO   A C   1 
ATOM   3389 O  O   . PRO   A 1 467 ? -32.993 -34.089 -21.611 1.00 109.30 ? 488 PRO   A O   1 
ATOM   3390 C  CB  . PRO   A 1 467 ? -33.341 -33.181 -18.604 1.00 105.83 ? 488 PRO   A CB  1 
ATOM   3391 C  CG  . PRO   A 1 467 ? -34.451 -32.236 -18.253 1.00 106.59 ? 488 PRO   A CG  1 
ATOM   3392 C  CD  . PRO   A 1 467 ? -34.911 -31.658 -19.556 1.00 105.69 ? 488 PRO   A CD  1 
ATOM   3393 N  N   . VAL   A 1 468 ? -30.902 -33.879 -20.800 1.00 109.30 ? 489 VAL   A N   1 
ATOM   3394 C  CA  . VAL   A 1 468 ? -30.321 -34.832 -21.740 1.00 107.83 ? 489 VAL   A CA  1 
ATOM   3395 C  C   . VAL   A 1 468 ? -30.674 -36.244 -21.297 1.00 108.05 ? 489 VAL   A C   1 
ATOM   3396 O  O   . VAL   A 1 468 ? -30.406 -36.635 -20.155 1.00 110.35 ? 489 VAL   A O   1 
ATOM   3397 C  CB  . VAL   A 1 468 ? -28.799 -34.644 -21.839 1.00 104.71 ? 489 VAL   A CB  1 
ATOM   3398 C  CG1 . VAL   A 1 468 ? -28.179 -35.746 -22.686 1.00 104.77 ? 489 VAL   A CG1 1 
ATOM   3399 C  CG2 . VAL   A 1 468 ? -28.469 -33.279 -22.419 1.00 108.29 ? 489 VAL   A CG2 1 
ATOM   3400 N  N   . VAL   A 1 469 ? -31.286 -37.009 -22.197 1.00 108.17 ? 490 VAL   A N   1 
ATOM   3401 C  CA  . VAL   A 1 469 ? -31.667 -38.394 -21.944 1.00 111.86 ? 490 VAL   A CA  1 
ATOM   3402 C  C   . VAL   A 1 469 ? -31.012 -39.263 -23.010 1.00 110.56 ? 490 VAL   A C   1 
ATOM   3403 O  O   . VAL   A 1 469 ? -31.100 -38.959 -24.205 1.00 111.73 ? 490 VAL   A O   1 
ATOM   3404 C  CB  . VAL   A 1 469 ? -33.196 -38.576 -21.948 1.00 114.85 ? 490 VAL   A CB  1 
ATOM   3405 C  CG1 . VAL   A 1 469 ? -33.569 -39.956 -21.430 1.00 114.48 ? 490 VAL   A CG1 1 
ATOM   3406 C  CG2 . VAL   A 1 469 ? -33.865 -37.490 -21.115 1.00 113.31 ? 490 VAL   A CG2 1 
ATOM   3407 N  N   . LEU   A 1 470 ? -30.354 -40.336 -22.577 1.00 110.70 ? 491 LEU   A N   1 
ATOM   3408 C  CA  . LEU   A 1 470 ? -29.604 -41.201 -23.475 1.00 112.57 ? 491 LEU   A CA  1 
ATOM   3409 C  C   . LEU   A 1 470 ? -29.904 -42.658 -23.152 1.00 116.69 ? 491 LEU   A C   1 
ATOM   3410 O  O   . LEU   A 1 470 ? -30.593 -42.977 -22.178 1.00 118.30 ? 491 LEU   A O   1 
ATOM   3411 C  CB  . LEU   A 1 470 ? -28.095 -40.936 -23.379 1.00 109.09 ? 491 LEU   A CB  1 
ATOM   3412 C  CG  . LEU   A 1 470 ? -27.619 -39.510 -23.660 1.00 106.68 ? 491 LEU   A CG  1 
ATOM   3413 C  CD1 . LEU   A 1 470 ? -26.144 -39.376 -23.327 1.00 101.70 ? 491 LEU   A CD1 1 
ATOM   3414 C  CD2 . LEU   A 1 470 ? -27.882 -39.135 -25.109 1.00 110.42 ? 491 LEU   A CD2 1 
ATOM   3415 N  N   . LYS   A 1 471 ? -29.379 -43.546 -23.990 1.00 112.34 ? 492 LYS   A N   1 
ATOM   3416 C  CA  . LYS   A 1 471 ? -29.486 -44.984 -23.786 1.00 110.01 ? 492 LYS   A CA  1 
ATOM   3417 C  C   . LYS   A 1 471 ? -28.156 -45.520 -23.273 1.00 109.17 ? 492 LYS   A C   1 
ATOM   3418 O  O   . LYS   A 1 471 ? -27.094 -45.174 -23.802 1.00 106.03 ? 492 LYS   A O   1 
ATOM   3419 C  CB  . LYS   A 1 471 ? -29.882 -45.693 -25.084 1.00 107.74 ? 492 LYS   A CB  1 
ATOM   3420 N  N   . VAL   A 1 472 ? -28.218 -46.364 -22.247 1.00 109.35 ? 493 VAL   A N   1 
ATOM   3421 C  CA  . VAL   A 1 472 ? -27.033 -46.907 -21.592 1.00 107.30 ? 493 VAL   A CA  1 
ATOM   3422 C  C   . VAL   A 1 472 ? -26.951 -48.392 -21.919 1.00 109.17 ? 493 VAL   A C   1 
ATOM   3423 O  O   . VAL   A 1 472 ? -27.880 -49.153 -21.620 1.00 112.81 ? 493 VAL   A O   1 
ATOM   3424 C  CB  . VAL   A 1 472 ? -27.071 -46.675 -20.073 1.00 109.51 ? 493 VAL   A CB  1 
ATOM   3425 C  CG1 . VAL   A 1 472 ? -25.714 -46.962 -19.454 1.00 108.16 ? 493 VAL   A CG1 1 
ATOM   3426 C  CG2 . VAL   A 1 472 ? -27.514 -45.253 -19.767 1.00 110.76 ? 493 VAL   A CG2 1 
ATOM   3427 N  N   . GLU   A 1 473 ? -25.841 -48.803 -22.527 1.00 109.88 ? 494 GLU   A N   1 
ATOM   3428 C  CA  . GLU   A 1 473 ? -25.628 -50.182 -22.948 1.00 110.73 ? 494 GLU   A CA  1 
ATOM   3429 C  C   . GLU   A 1 473 ? -24.449 -50.763 -22.182 1.00 111.52 ? 494 GLU   A C   1 
ATOM   3430 O  O   . GLU   A 1 473 ? -23.394 -50.128 -22.085 1.00 111.74 ? 494 GLU   A O   1 
ATOM   3431 C  CB  . GLU   A 1 473 ? -25.370 -50.260 -24.456 1.00 109.99 ? 494 GLU   A CB  1 
ATOM   3432 C  CG  . GLU   A 1 473 ? -26.292 -49.384 -25.292 1.00 113.99 ? 494 GLU   A CG  1 
ATOM   3433 C  CD  . GLU   A 1 473 ? -27.405 -50.165 -25.965 1.00 115.14 ? 494 GLU   A CD  1 
ATOM   3434 O  OE1 . GLU   A 1 473 ? -27.331 -51.412 -25.992 1.00 121.05 ? 494 GLU   A OE1 1 
ATOM   3435 O  OE2 . GLU   A 1 473 ? -28.353 -49.529 -26.471 1.00 110.25 ? 494 GLU   A OE2 1 
ATOM   3436 N  N   . SER   A 1 474 ? -24.626 -51.968 -21.646 1.00 111.27 ? 495 SER   A N   1 
ATOM   3437 C  CA  . SER   A 1 474 ? -23.585 -52.606 -20.853 1.00 108.50 ? 495 SER   A CA  1 
ATOM   3438 C  C   . SER   A 1 474 ? -22.557 -53.274 -21.757 1.00 108.81 ? 495 SER   A C   1 
ATOM   3439 O  O   . SER   A 1 474 ? -22.908 -54.084 -22.621 1.00 112.22 ? 495 SER   A O   1 
ATOM   3440 C  CB  . SER   A 1 474 ? -24.194 -53.634 -19.901 1.00 109.66 ? 495 SER   A CB  1 
ATOM   3441 O  OG  . SER   A 1 474 ? -23.184 -54.324 -19.186 1.00 108.55 ? 495 SER   A OG  1 
ATOM   3442 N  N   . ARG   A 1 475 ? -21.287 -52.939 -21.551 1.00 108.26 ? 496 ARG   A N   1 
ATOM   3443 C  CA  . ARG   A 1 475 ? -20.196 -53.558 -22.296 1.00 109.78 ? 496 ARG   A CA  1 
ATOM   3444 C  C   . ARG   A 1 475 ? -19.897 -54.952 -21.753 1.00 108.67 ? 496 ARG   A C   1 
ATOM   3445 O  O   . ARG   A 1 475 ? -19.590 -55.873 -22.510 1.00 106.27 ? 496 ARG   A O   1 
ATOM   3446 C  CB  . ARG   A 1 475 ? -18.936 -52.690 -22.234 1.00 110.74 ? 496 ARG   A CB  1 
ATOM   3447 C  CG  . ARG   A 1 475 ? -19.077 -51.328 -22.894 1.00 106.76 ? 496 ARG   A CG  1 
ATOM   3448 C  CD  . ARG   A 1 475 ? -17.855 -50.462 -22.620 1.00 107.10 ? 496 ARG   A CD  1 
ATOM   3449 N  NE  . ARG   A 1 475 ? -16.631 -51.050 -23.152 1.00 108.23 ? 496 ARG   A NE  1 
ATOM   3450 C  CZ  . ARG   A 1 475 ? -15.409 -50.621 -22.868 1.00 109.20 ? 496 ARG   A CZ  1 
ATOM   3451 N  NH1 . ARG   A 1 475 ? -15.206 -49.604 -22.045 1.00 109.59 ? 496 ARG   A NH1 1 
ATOM   3452 N  NH2 . ARG   A 1 475 ? -14.362 -51.228 -23.421 1.00 107.54 ? 496 ARG   A NH2 1 
HETATM 3453 C  CHA . HEM   B 2 .   ? -15.154 -19.724 -8.521  1.00 69.77  ? 601 HEM   A CHA 1 
HETATM 3454 C  CHB . HEM   B 2 .   ? -15.748 -22.651 -12.426 1.00 71.75  ? 601 HEM   A CHB 1 
HETATM 3455 C  CHC . HEM   B 2 .   ? -16.354 -26.350 -9.351  1.00 74.78  ? 601 HEM   A CHC 1 
HETATM 3456 C  CHD . HEM   B 2 .   ? -15.352 -23.566 -5.541  1.00 73.94  ? 601 HEM   A CHD 1 
HETATM 3457 C  C1A . HEM   B 2 .   ? -15.290 -20.191 -9.822  1.00 69.95  ? 601 HEM   A C1A 1 
HETATM 3458 C  C2A . HEM   B 2 .   ? -15.253 -19.371 -11.015 1.00 68.28  ? 601 HEM   A C2A 1 
HETATM 3459 C  C3A . HEM   B 2 .   ? -15.411 -20.175 -12.077 1.00 68.17  ? 601 HEM   A C3A 1 
HETATM 3460 C  C4A . HEM   B 2 .   ? -15.561 -21.535 -11.611 1.00 68.29  ? 601 HEM   A C4A 1 
HETATM 3461 C  CMA . HEM   B 2 .   ? -15.440 -19.762 -13.555 1.00 67.82  ? 601 HEM   A CMA 1 
HETATM 3462 C  CAA . HEM   B 2 .   ? -15.052 -17.836 -11.065 1.00 65.24  ? 601 HEM   A CAA 1 
HETATM 3463 C  CBA . HEM   B 2 .   ? -13.570 -17.494 -11.097 1.00 62.81  ? 601 HEM   A CBA 1 
HETATM 3464 C  CGA . HEM   B 2 .   ? -13.396 -16.061 -11.488 1.00 63.74  ? 601 HEM   A CGA 1 
HETATM 3465 O  O1A . HEM   B 2 .   ? -12.283 -15.723 -12.003 1.00 65.67  ? 601 HEM   A O1A 1 
HETATM 3466 O  O2A . HEM   B 2 .   ? -14.223 -15.193 -11.090 1.00 69.90  ? 601 HEM   A O2A 1 
HETATM 3467 C  C1B . HEM   B 2 .   ? -15.997 -23.916 -11.931 1.00 73.61  ? 601 HEM   A C1B 1 
HETATM 3468 C  C2B . HEM   B 2 .   ? -16.322 -25.113 -12.705 1.00 75.12  ? 601 HEM   A C2B 1 
HETATM 3469 C  C3B . HEM   B 2 .   ? -16.486 -26.130 -11.843 1.00 74.81  ? 601 HEM   A C3B 1 
HETATM 3470 C  C4B . HEM   B 2 .   ? -16.272 -25.604 -10.503 1.00 75.03  ? 601 HEM   A C4B 1 
HETATM 3471 C  CMB . HEM   B 2 .   ? -16.429 -25.137 -14.255 1.00 76.75  ? 601 HEM   A CMB 1 
HETATM 3472 C  CAB . HEM   B 2 .   ? -16.829 -27.616 -12.068 1.00 79.23  ? 601 HEM   A CAB 1 
HETATM 3473 C  CBB . HEM   B 2 .   ? -17.324 -28.178 -13.173 1.00 86.10  ? 601 HEM   A CBB 1 
HETATM 3474 C  C1C . HEM   B 2 .   ? -16.130 -25.935 -8.071  1.00 75.34  ? 601 HEM   A C1C 1 
HETATM 3475 C  C2C . HEM   B 2 .   ? -16.194 -26.777 -6.905  1.00 76.30  ? 601 HEM   A C2C 1 
HETATM 3476 C  C3C . HEM   B 2 .   ? -15.917 -26.022 -5.831  1.00 75.08  ? 601 HEM   A C3C 1 
HETATM 3477 C  C4C . HEM   B 2 .   ? -15.671 -24.679 -6.294  1.00 76.31  ? 601 HEM   A C4C 1 
HETATM 3478 C  CMC . HEM   B 2 .   ? -16.521 -28.273 -6.955  1.00 80.05  ? 601 HEM   A CMC 1 
HETATM 3479 C  CAC . HEM   B 2 .   ? -15.866 -26.446 -4.354  1.00 74.84  ? 601 HEM   A CAC 1 
HETATM 3480 C  CBC . HEM   B 2 .   ? -14.808 -26.262 -3.573  1.00 85.69  ? 601 HEM   A CBC 1 
HETATM 3481 C  C1D . HEM   B 2 .   ? -15.239 -22.285 -6.030  1.00 70.95  ? 601 HEM   A C1D 1 
HETATM 3482 C  C2D . HEM   B 2 .   ? -15.027 -21.102 -5.240  1.00 72.48  ? 601 HEM   A C2D 1 
HETATM 3483 C  C3D . HEM   B 2 .   ? -14.966 -20.033 -6.034  1.00 72.47  ? 601 HEM   A C3D 1 
HETATM 3484 C  C4D . HEM   B 2 .   ? -15.144 -20.502 -7.399  1.00 70.18  ? 601 HEM   A C4D 1 
HETATM 3485 C  CMD . HEM   B 2 .   ? -14.895 -21.146 -3.705  1.00 75.21  ? 601 HEM   A CMD 1 
HETATM 3486 C  CAD . HEM   B 2 .   ? -14.759 -18.574 -5.599  1.00 72.31  ? 601 HEM   A CAD 1 
HETATM 3487 C  CBD . HEM   B 2 .   ? -13.282 -18.209 -5.646  1.00 71.60  ? 601 HEM   A CBD 1 
HETATM 3488 C  CGD . HEM   B 2 .   ? -12.999 -16.996 -4.786  1.00 73.51  ? 601 HEM   A CGD 1 
HETATM 3489 O  O1D . HEM   B 2 .   ? -13.867 -16.080 -4.780  1.00 75.27  ? 601 HEM   A O1D 1 
HETATM 3490 O  O2D . HEM   B 2 .   ? -11.950 -16.952 -4.075  1.00 72.79  ? 601 HEM   A O2D 1 
HETATM 3491 N  NA  . HEM   B 2 .   ? -15.489 -21.501 -10.225 1.00 67.50  ? 601 HEM   A NA  1 
HETATM 3492 N  NB  . HEM   B 2 .   ? -15.980 -24.265 -10.597 1.00 75.01  ? 601 HEM   A NB  1 
HETATM 3493 N  NC  . HEM   B 2 .   ? -15.812 -24.665 -7.656  1.00 72.93  ? 601 HEM   A NC  1 
HETATM 3494 N  ND  . HEM   B 2 .   ? -15.308 -21.883 -7.345  1.00 69.86  ? 601 HEM   A ND  1 
HETATM 3495 FE FE  . HEM   B 2 .   ? -15.603 -23.114 -8.960  1.00 70.96  ? 601 HEM   A FE  1 
HETATM 3496 C  C01 . A1ASU C 3 .   ? -26.202 -23.295 -8.858  1.00 103.19 ? 602 A1ASU A C01 1 
HETATM 3497 C  C03 . A1ASU C 3 .   ? -24.013 -23.057 -9.709  1.00 98.57  ? 602 A1ASU A C03 1 
HETATM 3498 C  C04 . A1ASU C 3 .   ? -23.179 -22.511 -10.681 1.00 97.44  ? 602 A1ASU A C04 1 
HETATM 3499 C  C05 . A1ASU C 3 .   ? -21.839 -22.299 -10.386 1.00 91.25  ? 602 A1ASU A C05 1 
HETATM 3500 C  C06 . A1ASU C 3 .   ? -21.332 -22.626 -9.133  1.00 91.12  ? 602 A1ASU A C06 1 
HETATM 3501 C  C07 . A1ASU C 3 .   ? -22.175 -23.175 -8.168  1.00 91.15  ? 602 A1ASU A C07 1 
HETATM 3502 C  C08 . A1ASU C 3 .   ? -23.513 -23.393 -8.453  1.00 94.30  ? 602 A1ASU A C08 1 
HETATM 3503 C  C09 . A1ASU C 3 .   ? -19.916 -22.405 -8.840  1.00 87.21  ? 602 A1ASU A C09 1 
HETATM 3504 C  C10 . A1ASU C 3 .   ? -18.780 -22.928 -9.428  1.00 83.30  ? 602 A1ASU A C10 1 
HETATM 3505 C  C14 . A1ASU C 3 .   ? -20.188 -20.749 -6.910  1.00 87.11  ? 602 A1ASU A C14 1 
HETATM 3506 C  C15 . A1ASU C 3 .   ? -19.936 -20.866 -5.546  1.00 89.45  ? 602 A1ASU A C15 1 
HETATM 3507 C  C16 . A1ASU C 3 .   ? -20.658 -20.078 -4.666  1.00 90.56  ? 602 A1ASU A C16 1 
HETATM 3508 C  C17 . A1ASU C 3 .   ? -21.600 -19.189 -5.154  1.00 90.75  ? 602 A1ASU A C17 1 
HETATM 3509 C  C18 . A1ASU C 3 .   ? -21.841 -19.080 -6.510  1.00 91.32  ? 602 A1ASU A C18 1 
HETATM 3510 C  C19 . A1ASU C 3 .   ? -21.133 -19.856 -7.404  1.00 88.76  ? 602 A1ASU A C19 1 
HETATM 3511 C  C20 . A1ASU C 3 .   ? -22.364 -18.366 -4.222  1.00 96.36  ? 602 A1ASU A C20 1 
HETATM 3512 C  C21 . A1ASU C 3 .   ? -23.524 -17.716 -4.519  1.00 100.31 ? 602 A1ASU A C21 1 
HETATM 3513 C  C23 . A1ASU C 3 .   ? -22.733 -17.431 -2.230  1.00 98.67  ? 602 A1ASU A C23 1 
HETATM 3514 C  C24 . A1ASU C 3 .   ? -22.543 -17.065 -0.822  1.00 93.08  ? 602 A1ASU A C24 1 
HETATM 3515 N  N11 . A1ASU C 3 .   ? -17.673 -22.376 -8.756  1.00 79.66  ? 602 A1ASU A N11 1 
HETATM 3516 N  N12 . A1ASU C 3 .   ? -18.070 -21.579 -7.833  1.00 81.21  ? 602 A1ASU A N12 1 
HETATM 3517 N  N13 . A1ASU C 3 .   ? -19.441 -21.550 -7.829  1.00 84.01  ? 602 A1ASU A N13 1 
HETATM 3518 N  N25 . A1ASU C 3 .   ? -21.895 -18.212 -2.903  1.00 100.54 ? 602 A1ASU A N25 1 
HETATM 3519 O  O02 . A1ASU C 3 .   ? -25.336 -23.276 -9.970  1.00 102.09 ? 602 A1ASU A O02 1 
HETATM 3520 S  S22 . A1ASU C 3 .   ? -24.101 -16.869 -3.167  1.00 111.89 ? 602 A1ASU A S22 1 
HETATM 3521 C  C5  . PG0   D 4 .   ? -19.651 -19.397 -11.065 1.00 79.15  ? 603 PG0   A C5  1 
HETATM 3522 O  O2  . PG0   D 4 .   ? -19.039 -19.168 -9.823  1.00 76.05  ? 603 PG0   A O2  1 
HETATM 3523 C  C4  . PG0   D 4 .   ? -18.854 -17.801 -9.564  1.00 75.51  ? 603 PG0   A C4  1 
HETATM 3524 C  C3  . PG0   D 4 .   ? -18.204 -17.619 -8.217  1.00 76.41  ? 603 PG0   A C3  1 
HETATM 3525 O  O1  . PG0   D 4 .   ? -19.164 -17.251 -7.261  1.00 81.68  ? 603 PG0   A O1  1 
HETATM 3526 C  C2  . PG0   D 4 .   ? -19.799 -16.031 -7.549  1.00 83.01  ? 603 PG0   A C2  1 
HETATM 3527 C  C1  . PG0   D 4 .   ? -20.648 -15.612 -6.376  1.00 85.01  ? 603 PG0   A C1  1 
HETATM 3528 O  OTT . PG0   D 4 .   ? -21.889 -15.132 -6.838  1.00 88.00  ? 603 PG0   A OTT 1 
HETATM 3529 O  O   . HOH   E 5 .   ? -24.202 -15.857 -8.158  1.00 79.65  ? 701 HOH   A O   1 
# 
