data_9BTK
# 
_entry.id   9BTK 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BTK         pdb_00009btk 10.2210/pdb9btk/pdb 
WWPDB D_1000284101 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-05-21 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BTK 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-15 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              wliu@chem.tamu.edu 
_pdbx_contact_author.name_first         Wenshe 
_pdbx_contact_author.name_last          Liu 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-7078-6534 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Blankenship, L.R.' 1 0000-0002-1714-4399 
'Liu, W.R.'         2 0000-0002-7078-6534 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Structure of the SARS-CoV-2 main protease' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Blankenship, L.R.' 1 ? 
primary 'Liu, W.R.'         2 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '3C-like proteinase nsp5' 33825.547 1   3.4.22.69 ? ? ? 
2 non-polymer syn 
;(1R,2S,5R)-N-[(1R)-2-imino-1-(isoquinolin-4-yl)ethyl]-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-D-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide
;
531.570   1   ?         ? ? ? 
3 water       nat water 18.015    272 ?         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 
;(1R,2S,5R)-N-[(1R)-2-imino-1-(isoquinolin-4-yl)ethyl]-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-D-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide
;
A1ASG 
3 water HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   GLY n 
1 3   PHE n 
1 4   ARG n 
1 5   LYS n 
1 6   MET n 
1 7   ALA n 
1 8   PHE n 
1 9   PRO n 
1 10  SER n 
1 11  GLY n 
1 12  LYS n 
1 13  VAL n 
1 14  GLU n 
1 15  GLY n 
1 16  CYS n 
1 17  MET n 
1 18  VAL n 
1 19  GLN n 
1 20  VAL n 
1 21  THR n 
1 22  CYS n 
1 23  GLY n 
1 24  THR n 
1 25  THR n 
1 26  THR n 
1 27  LEU n 
1 28  ASN n 
1 29  GLY n 
1 30  LEU n 
1 31  TRP n 
1 32  LEU n 
1 33  ASP n 
1 34  ASP n 
1 35  VAL n 
1 36  VAL n 
1 37  TYR n 
1 38  CYS n 
1 39  PRO n 
1 40  ARG n 
1 41  HIS n 
1 42  VAL n 
1 43  ILE n 
1 44  CYS n 
1 45  THR n 
1 46  SER n 
1 47  GLU n 
1 48  ASP n 
1 49  MET n 
1 50  LEU n 
1 51  ASN n 
1 52  PRO n 
1 53  ASN n 
1 54  TYR n 
1 55  GLU n 
1 56  ASP n 
1 57  LEU n 
1 58  LEU n 
1 59  ILE n 
1 60  ARG n 
1 61  LYS n 
1 62  SER n 
1 63  ASN n 
1 64  HIS n 
1 65  ASN n 
1 66  PHE n 
1 67  LEU n 
1 68  VAL n 
1 69  GLN n 
1 70  ALA n 
1 71  GLY n 
1 72  ASN n 
1 73  VAL n 
1 74  GLN n 
1 75  LEU n 
1 76  ARG n 
1 77  VAL n 
1 78  ILE n 
1 79  GLY n 
1 80  HIS n 
1 81  SER n 
1 82  MET n 
1 83  GLN n 
1 84  ASN n 
1 85  CYS n 
1 86  VAL n 
1 87  LEU n 
1 88  LYS n 
1 89  LEU n 
1 90  LYS n 
1 91  VAL n 
1 92  ASP n 
1 93  THR n 
1 94  ALA n 
1 95  ASN n 
1 96  PRO n 
1 97  LYS n 
1 98  THR n 
1 99  PRO n 
1 100 LYS n 
1 101 TYR n 
1 102 LYS n 
1 103 PHE n 
1 104 VAL n 
1 105 ARG n 
1 106 ILE n 
1 107 GLN n 
1 108 PRO n 
1 109 GLY n 
1 110 GLN n 
1 111 THR n 
1 112 PHE n 
1 113 SER n 
1 114 VAL n 
1 115 LEU n 
1 116 ALA n 
1 117 CYS n 
1 118 TYR n 
1 119 ASN n 
1 120 GLY n 
1 121 SER n 
1 122 PRO n 
1 123 SER n 
1 124 GLY n 
1 125 VAL n 
1 126 TYR n 
1 127 GLN n 
1 128 CYS n 
1 129 ALA n 
1 130 MET n 
1 131 ARG n 
1 132 PRO n 
1 133 ASN n 
1 134 PHE n 
1 135 THR n 
1 136 ILE n 
1 137 LYS n 
1 138 GLY n 
1 139 SER n 
1 140 PHE n 
1 141 LEU n 
1 142 ASN n 
1 143 GLY n 
1 144 SER n 
1 145 CYS n 
1 146 GLY n 
1 147 SER n 
1 148 VAL n 
1 149 GLY n 
1 150 PHE n 
1 151 ASN n 
1 152 ILE n 
1 153 ASP n 
1 154 TYR n 
1 155 ASP n 
1 156 CYS n 
1 157 VAL n 
1 158 SER n 
1 159 PHE n 
1 160 CYS n 
1 161 TYR n 
1 162 MET n 
1 163 HIS n 
1 164 HIS n 
1 165 MET n 
1 166 GLU n 
1 167 LEU n 
1 168 PRO n 
1 169 THR n 
1 170 GLY n 
1 171 VAL n 
1 172 HIS n 
1 173 ALA n 
1 174 GLY n 
1 175 THR n 
1 176 ASP n 
1 177 LEU n 
1 178 GLU n 
1 179 GLY n 
1 180 ASN n 
1 181 PHE n 
1 182 TYR n 
1 183 GLY n 
1 184 PRO n 
1 185 PHE n 
1 186 VAL n 
1 187 ASP n 
1 188 ARG n 
1 189 GLN n 
1 190 THR n 
1 191 ALA n 
1 192 GLN n 
1 193 ALA n 
1 194 ALA n 
1 195 GLY n 
1 196 THR n 
1 197 ASP n 
1 198 THR n 
1 199 THR n 
1 200 ILE n 
1 201 THR n 
1 202 VAL n 
1 203 ASN n 
1 204 VAL n 
1 205 LEU n 
1 206 ALA n 
1 207 TRP n 
1 208 LEU n 
1 209 TYR n 
1 210 ALA n 
1 211 ALA n 
1 212 VAL n 
1 213 ILE n 
1 214 ASN n 
1 215 GLY n 
1 216 ASP n 
1 217 ARG n 
1 218 TRP n 
1 219 PHE n 
1 220 LEU n 
1 221 ASN n 
1 222 ARG n 
1 223 PHE n 
1 224 THR n 
1 225 THR n 
1 226 THR n 
1 227 LEU n 
1 228 ASN n 
1 229 ASP n 
1 230 PHE n 
1 231 ASN n 
1 232 LEU n 
1 233 VAL n 
1 234 ALA n 
1 235 MET n 
1 236 LYS n 
1 237 TYR n 
1 238 ASN n 
1 239 TYR n 
1 240 GLU n 
1 241 PRO n 
1 242 LEU n 
1 243 THR n 
1 244 GLN n 
1 245 ASP n 
1 246 HIS n 
1 247 VAL n 
1 248 ASP n 
1 249 ILE n 
1 250 LEU n 
1 251 GLY n 
1 252 PRO n 
1 253 LEU n 
1 254 SER n 
1 255 ALA n 
1 256 GLN n 
1 257 THR n 
1 258 GLY n 
1 259 ILE n 
1 260 ALA n 
1 261 VAL n 
1 262 LEU n 
1 263 ASP n 
1 264 MET n 
1 265 CYS n 
1 266 ALA n 
1 267 SER n 
1 268 LEU n 
1 269 LYS n 
1 270 GLU n 
1 271 LEU n 
1 272 LEU n 
1 273 GLN n 
1 274 ASN n 
1 275 GLY n 
1 276 MET n 
1 277 ASN n 
1 278 GLY n 
1 279 ARG n 
1 280 THR n 
1 281 ILE n 
1 282 LEU n 
1 283 GLY n 
1 284 SER n 
1 285 ALA n 
1 286 LEU n 
1 287 LEU n 
1 288 GLU n 
1 289 ASP n 
1 290 GLU n 
1 291 PHE n 
1 292 THR n 
1 293 PRO n 
1 294 PHE n 
1 295 ASP n 
1 296 VAL n 
1 297 VAL n 
1 298 ARG n 
1 299 GLN n 
1 300 CYS n 
1 301 SER n 
1 302 GLY n 
1 303 VAL n 
1 304 THR n 
1 305 PHE n 
1 306 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   306 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'rep, 1a-1b' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1ASG non-polymer         . 
;(1R,2S,5R)-N-[(1R)-2-imino-1-(isoquinolin-4-yl)ethyl]-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-D-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide
;
? 'C27 H32 F3 N5 O3' 531.570 
ALA   'L-peptide linking' y ALANINE ? 'C3 H7 N O2'       89.093  
ARG   'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1'   175.209 
ASN   'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'      132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'       133.103 
CYS   'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'     121.158 
GLN   'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'     146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'       147.129 
GLY   'peptide linking'   y GLYCINE ? 'C2 H5 N O2'       75.067  
HIS   'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1'   156.162 
HOH   non-polymer         . WATER ? 'H2 O'             18.015  
ILE   'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'      131.173 
LEU   'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'      131.173 
LYS   'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1'   147.195 
MET   'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'    149.211 
PHE   'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'      165.189 
PRO   'L-peptide linking' y PROLINE ? 'C5 H9 N O2'       115.130 
SER   'L-peptide linking' y SERINE ? 'C3 H7 N O3'       105.093 
THR   'L-peptide linking' y THREONINE ? 'C4 H9 N O3'       119.119 
TRP   'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'    204.225 
TYR   'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'      181.189 
VAL   'L-peptide linking' y VALINE ? 'C5 H11 N O2'      117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   1   1   SER SER A . n 
A 1 2   GLY 2   2   2   GLY GLY A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   ARG 4   4   4   ARG ARG A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   MET 6   6   6   MET MET A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   PRO 9   9   9   PRO PRO A . n 
A 1 10  SER 10  10  10  SER SER A . n 
A 1 11  GLY 11  11  11  GLY GLY A . n 
A 1 12  LYS 12  12  12  LYS LYS A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  GLY 15  15  15  GLY GLY A . n 
A 1 16  CYS 16  16  16  CYS CYS A . n 
A 1 17  MET 17  17  17  MET MET A . n 
A 1 18  VAL 18  18  18  VAL VAL A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  THR 21  21  21  THR THR A . n 
A 1 22  CYS 22  22  22  CYS CYS A . n 
A 1 23  GLY 23  23  23  GLY GLY A . n 
A 1 24  THR 24  24  24  THR THR A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  THR 26  26  26  THR THR A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  ASN 28  28  28  ASN ASN A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  TRP 31  31  31  TRP TRP A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  ASP 33  33  33  ASP ASP A . n 
A 1 34  ASP 34  34  34  ASP ASP A . n 
A 1 35  VAL 35  35  35  VAL VAL A . n 
A 1 36  VAL 36  36  36  VAL VAL A . n 
A 1 37  TYR 37  37  37  TYR TYR A . n 
A 1 38  CYS 38  38  38  CYS CYS A . n 
A 1 39  PRO 39  39  39  PRO PRO A . n 
A 1 40  ARG 40  40  40  ARG ARG A . n 
A 1 41  HIS 41  41  41  HIS HIS A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  ILE 43  43  43  ILE ILE A . n 
A 1 44  CYS 44  44  44  CYS CYS A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  SER 46  46  46  SER SER A . n 
A 1 47  GLU 47  47  47  GLU GLU A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  MET 49  49  49  MET MET A . n 
A 1 50  LEU 50  50  50  LEU LEU A . n 
A 1 51  ASN 51  51  51  ASN ASN A . n 
A 1 52  PRO 52  52  52  PRO PRO A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  TYR 54  54  54  TYR TYR A . n 
A 1 55  GLU 55  55  55  GLU GLU A . n 
A 1 56  ASP 56  56  56  ASP ASP A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  ILE 59  59  59  ILE ILE A . n 
A 1 60  ARG 60  60  60  ARG ARG A . n 
A 1 61  LYS 61  61  61  LYS LYS A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  ASN 63  63  63  ASN ASN A . n 
A 1 64  HIS 64  64  64  HIS HIS A . n 
A 1 65  ASN 65  65  65  ASN ASN A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  GLN 69  69  69  GLN GLN A . n 
A 1 70  ALA 70  70  70  ALA ALA A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  ASN 72  72  72  ASN ASN A . n 
A 1 73  VAL 73  73  73  VAL VAL A . n 
A 1 74  GLN 74  74  74  GLN GLN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  ARG 76  76  76  ARG ARG A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  GLY 79  79  79  GLY GLY A . n 
A 1 80  HIS 80  80  80  HIS HIS A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  MET 82  82  82  MET MET A . n 
A 1 83  GLN 83  83  83  GLN GLN A . n 
A 1 84  ASN 84  84  84  ASN ASN A . n 
A 1 85  CYS 85  85  85  CYS CYS A . n 
A 1 86  VAL 86  86  86  VAL VAL A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  LYS 88  88  88  LYS LYS A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  LYS 90  90  90  LYS LYS A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  ASP 92  92  92  ASP ASP A . n 
A 1 93  THR 93  93  93  THR THR A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  PRO 96  96  96  PRO PRO A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  PRO 99  99  99  PRO PRO A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 TYR 101 101 101 TYR TYR A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 PHE 103 103 103 PHE PHE A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 ARG 105 105 105 ARG ARG A . n 
A 1 106 ILE 106 106 106 ILE ILE A . n 
A 1 107 GLN 107 107 107 GLN GLN A . n 
A 1 108 PRO 108 108 108 PRO PRO A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 GLN 110 110 110 GLN GLN A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 PHE 112 112 112 PHE PHE A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 CYS 117 117 117 CYS CYS A . n 
A 1 118 TYR 118 118 118 TYR TYR A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 SER 123 123 123 SER SER A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 MET 130 130 130 MET MET A . n 
A 1 131 ARG 131 131 131 ARG ARG A . n 
A 1 132 PRO 132 132 132 PRO PRO A . n 
A 1 133 ASN 133 133 133 ASN ASN A . n 
A 1 134 PHE 134 134 134 PHE PHE A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 LYS 137 137 137 LYS LYS A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 PHE 140 140 140 PHE PHE A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 ASN 142 142 142 ASN ASN A . n 
A 1 143 GLY 143 143 143 GLY GLY A . n 
A 1 144 SER 144 144 144 SER SER A . n 
A 1 145 CYS 145 145 145 CYS CYS A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 GLY 149 149 149 GLY GLY A . n 
A 1 150 PHE 150 150 150 PHE PHE A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 ILE 152 152 152 ILE ILE A . n 
A 1 153 ASP 153 153 153 ASP ASP A . n 
A 1 154 TYR 154 154 154 TYR TYR A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 CYS 156 156 156 CYS CYS A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 SER 158 158 158 SER SER A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 CYS 160 160 160 CYS CYS A . n 
A 1 161 TYR 161 161 161 TYR TYR A . n 
A 1 162 MET 162 162 162 MET MET A . n 
A 1 163 HIS 163 163 163 HIS HIS A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 MET 165 165 165 MET MET A . n 
A 1 166 GLU 166 166 166 GLU GLU A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 PRO 168 168 168 PRO PRO A . n 
A 1 169 THR 169 169 169 THR THR A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 VAL 171 171 171 VAL VAL A . n 
A 1 172 HIS 172 172 172 HIS HIS A . n 
A 1 173 ALA 173 173 173 ALA ALA A . n 
A 1 174 GLY 174 174 174 GLY GLY A . n 
A 1 175 THR 175 175 175 THR THR A . n 
A 1 176 ASP 176 176 176 ASP ASP A . n 
A 1 177 LEU 177 177 177 LEU LEU A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 TYR 182 182 182 TYR TYR A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 VAL 186 186 186 VAL VAL A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 GLN 189 189 189 GLN GLN A . n 
A 1 190 THR 190 190 190 THR THR A . n 
A 1 191 ALA 191 191 191 ALA ALA A . n 
A 1 192 GLN 192 192 192 GLN GLN A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 THR 196 196 196 THR THR A . n 
A 1 197 ASP 197 197 197 ASP ASP A . n 
A 1 198 THR 198 198 198 THR THR A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 ILE 200 200 200 ILE ILE A . n 
A 1 201 THR 201 201 201 THR THR A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 ALA 206 206 206 ALA ALA A . n 
A 1 207 TRP 207 207 207 TRP TRP A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ALA 210 210 210 ALA ALA A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ASN 214 214 214 ASN ASN A . n 
A 1 215 GLY 215 215 215 GLY GLY A . n 
A 1 216 ASP 216 216 216 ASP ASP A . n 
A 1 217 ARG 217 217 217 ARG ARG A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 ASN 221 221 221 ASN ASN A . n 
A 1 222 ARG 222 222 222 ARG ARG A . n 
A 1 223 PHE 223 223 223 PHE PHE A . n 
A 1 224 THR 224 224 224 THR THR A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 THR 226 226 226 THR THR A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 ASN 228 228 228 ASN ASN A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 PHE 230 230 230 PHE PHE A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 VAL 233 233 233 VAL VAL A . n 
A 1 234 ALA 234 234 234 ALA ALA A . n 
A 1 235 MET 235 235 235 MET MET A . n 
A 1 236 LYS 236 236 236 LYS LYS A . n 
A 1 237 TYR 237 237 237 TYR TYR A . n 
A 1 238 ASN 238 238 238 ASN ASN A . n 
A 1 239 TYR 239 239 239 TYR TYR A . n 
A 1 240 GLU 240 240 240 GLU GLU A . n 
A 1 241 PRO 241 241 241 PRO PRO A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 THR 243 243 243 THR THR A . n 
A 1 244 GLN 244 244 244 GLN GLN A . n 
A 1 245 ASP 245 245 245 ASP ASP A . n 
A 1 246 HIS 246 246 246 HIS HIS A . n 
A 1 247 VAL 247 247 247 VAL VAL A . n 
A 1 248 ASP 248 248 248 ASP ASP A . n 
A 1 249 ILE 249 249 249 ILE ILE A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 PRO 252 252 252 PRO PRO A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 SER 254 254 254 SER SER A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 THR 257 257 257 THR THR A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 ILE 259 259 259 ILE ILE A . n 
A 1 260 ALA 260 260 260 ALA ALA A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 LEU 262 262 262 LEU LEU A . n 
A 1 263 ASP 263 263 263 ASP ASP A . n 
A 1 264 MET 264 264 264 MET MET A . n 
A 1 265 CYS 265 265 265 CYS CYS A . n 
A 1 266 ALA 266 266 266 ALA ALA A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 LYS 269 269 269 LYS LYS A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 LEU 271 271 271 LEU LEU A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 ASN 274 274 274 ASN ASN A . n 
A 1 275 GLY 275 275 275 GLY GLY A . n 
A 1 276 MET 276 276 276 MET MET A . n 
A 1 277 ASN 277 277 277 ASN ASN A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 ARG 279 279 279 ARG ARG A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 ILE 281 281 281 ILE ILE A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 GLY 283 283 283 GLY GLY A . n 
A 1 284 SER 284 284 284 SER SER A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 LEU 286 286 286 LEU LEU A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 ASP 289 289 289 ASP ASP A . n 
A 1 290 GLU 290 290 290 GLU GLU A . n 
A 1 291 PHE 291 291 291 PHE PHE A . n 
A 1 292 THR 292 292 292 THR THR A . n 
A 1 293 PRO 293 293 293 PRO PRO A . n 
A 1 294 PHE 294 294 294 PHE PHE A . n 
A 1 295 ASP 295 295 295 ASP ASP A . n 
A 1 296 VAL 296 296 296 VAL VAL A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 GLN 299 299 299 GLN GLN A . n 
A 1 300 CYS 300 300 300 CYS CYS A . n 
A 1 301 SER 301 301 301 SER SER A . n 
A 1 302 GLY 302 302 302 GLY GLY A . n 
A 1 303 VAL 303 303 303 VAL VAL A . n 
A 1 304 THR 304 304 304 THR THR A . n 
A 1 305 PHE 305 305 305 PHE PHE A . n 
A 1 306 GLN 306 306 306 GLN GLN A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1ASG 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1ASG 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 A1ASG 1   401 401 A1ASG LIG A . 
C 3 HOH   1   501 204 HOH   HOH A . 
C 3 HOH   2   502 238 HOH   HOH A . 
C 3 HOH   3   503 213 HOH   HOH A . 
C 3 HOH   4   504 103 HOH   HOH A . 
C 3 HOH   5   505 205 HOH   HOH A . 
C 3 HOH   6   506 206 HOH   HOH A . 
C 3 HOH   7   507 155 HOH   HOH A . 
C 3 HOH   8   508 26  HOH   HOH A . 
C 3 HOH   9   509 79  HOH   HOH A . 
C 3 HOH   10  510 201 HOH   HOH A . 
C 3 HOH   11  511 58  HOH   HOH A . 
C 3 HOH   12  512 118 HOH   HOH A . 
C 3 HOH   13  513 72  HOH   HOH A . 
C 3 HOH   14  514 225 HOH   HOH A . 
C 3 HOH   15  515 210 HOH   HOH A . 
C 3 HOH   16  516 60  HOH   HOH A . 
C 3 HOH   17  517 75  HOH   HOH A . 
C 3 HOH   18  518 43  HOH   HOH A . 
C 3 HOH   19  519 171 HOH   HOH A . 
C 3 HOH   20  520 82  HOH   HOH A . 
C 3 HOH   21  521 122 HOH   HOH A . 
C 3 HOH   22  522 67  HOH   HOH A . 
C 3 HOH   23  523 77  HOH   HOH A . 
C 3 HOH   24  524 259 HOH   HOH A . 
C 3 HOH   25  525 176 HOH   HOH A . 
C 3 HOH   26  526 123 HOH   HOH A . 
C 3 HOH   27  527 84  HOH   HOH A . 
C 3 HOH   28  528 114 HOH   HOH A . 
C 3 HOH   29  529 256 HOH   HOH A . 
C 3 HOH   30  530 109 HOH   HOH A . 
C 3 HOH   31  531 111 HOH   HOH A . 
C 3 HOH   32  532 3   HOH   HOH A . 
C 3 HOH   33  533 39  HOH   HOH A . 
C 3 HOH   34  534 265 HOH   HOH A . 
C 3 HOH   35  535 76  HOH   HOH A . 
C 3 HOH   36  536 153 HOH   HOH A . 
C 3 HOH   37  537 264 HOH   HOH A . 
C 3 HOH   38  538 96  HOH   HOH A . 
C 3 HOH   39  539 24  HOH   HOH A . 
C 3 HOH   40  540 172 HOH   HOH A . 
C 3 HOH   41  541 180 HOH   HOH A . 
C 3 HOH   42  542 73  HOH   HOH A . 
C 3 HOH   43  543 51  HOH   HOH A . 
C 3 HOH   44  544 128 HOH   HOH A . 
C 3 HOH   45  545 188 HOH   HOH A . 
C 3 HOH   46  546 95  HOH   HOH A . 
C 3 HOH   47  547 124 HOH   HOH A . 
C 3 HOH   48  548 163 HOH   HOH A . 
C 3 HOH   49  549 269 HOH   HOH A . 
C 3 HOH   50  550 136 HOH   HOH A . 
C 3 HOH   51  551 154 HOH   HOH A . 
C 3 HOH   52  552 17  HOH   HOH A . 
C 3 HOH   53  553 94  HOH   HOH A . 
C 3 HOH   54  554 28  HOH   HOH A . 
C 3 HOH   55  555 137 HOH   HOH A . 
C 3 HOH   56  556 130 HOH   HOH A . 
C 3 HOH   57  557 202 HOH   HOH A . 
C 3 HOH   58  558 31  HOH   HOH A . 
C 3 HOH   59  559 49  HOH   HOH A . 
C 3 HOH   60  560 53  HOH   HOH A . 
C 3 HOH   61  561 25  HOH   HOH A . 
C 3 HOH   62  562 232 HOH   HOH A . 
C 3 HOH   63  563 200 HOH   HOH A . 
C 3 HOH   64  564 91  HOH   HOH A . 
C 3 HOH   65  565 27  HOH   HOH A . 
C 3 HOH   66  566 260 HOH   HOH A . 
C 3 HOH   67  567 8   HOH   HOH A . 
C 3 HOH   68  568 134 HOH   HOH A . 
C 3 HOH   69  569 13  HOH   HOH A . 
C 3 HOH   70  570 38  HOH   HOH A . 
C 3 HOH   71  571 40  HOH   HOH A . 
C 3 HOH   72  572 268 HOH   HOH A . 
C 3 HOH   73  573 87  HOH   HOH A . 
C 3 HOH   74  574 6   HOH   HOH A . 
C 3 HOH   75  575 11  HOH   HOH A . 
C 3 HOH   76  576 222 HOH   HOH A . 
C 3 HOH   77  577 29  HOH   HOH A . 
C 3 HOH   78  578 270 HOH   HOH A . 
C 3 HOH   79  579 22  HOH   HOH A . 
C 3 HOH   80  580 120 HOH   HOH A . 
C 3 HOH   81  581 35  HOH   HOH A . 
C 3 HOH   82  582 174 HOH   HOH A . 
C 3 HOH   83  583 65  HOH   HOH A . 
C 3 HOH   84  584 4   HOH   HOH A . 
C 3 HOH   85  585 236 HOH   HOH A . 
C 3 HOH   86  586 254 HOH   HOH A . 
C 3 HOH   87  587 263 HOH   HOH A . 
C 3 HOH   88  588 2   HOH   HOH A . 
C 3 HOH   89  589 108 HOH   HOH A . 
C 3 HOH   90  590 234 HOH   HOH A . 
C 3 HOH   91  591 119 HOH   HOH A . 
C 3 HOH   92  592 63  HOH   HOH A . 
C 3 HOH   93  593 57  HOH   HOH A . 
C 3 HOH   94  594 212 HOH   HOH A . 
C 3 HOH   95  595 183 HOH   HOH A . 
C 3 HOH   96  596 226 HOH   HOH A . 
C 3 HOH   97  597 64  HOH   HOH A . 
C 3 HOH   98  598 159 HOH   HOH A . 
C 3 HOH   99  599 221 HOH   HOH A . 
C 3 HOH   100 600 55  HOH   HOH A . 
C 3 HOH   101 601 50  HOH   HOH A . 
C 3 HOH   102 602 46  HOH   HOH A . 
C 3 HOH   103 603 97  HOH   HOH A . 
C 3 HOH   104 604 227 HOH   HOH A . 
C 3 HOH   105 605 166 HOH   HOH A . 
C 3 HOH   106 606 19  HOH   HOH A . 
C 3 HOH   107 607 178 HOH   HOH A . 
C 3 HOH   108 608 42  HOH   HOH A . 
C 3 HOH   109 609 48  HOH   HOH A . 
C 3 HOH   110 610 68  HOH   HOH A . 
C 3 HOH   111 611 157 HOH   HOH A . 
C 3 HOH   112 612 18  HOH   HOH A . 
C 3 HOH   113 613 21  HOH   HOH A . 
C 3 HOH   114 614 16  HOH   HOH A . 
C 3 HOH   115 615 52  HOH   HOH A . 
C 3 HOH   116 616 208 HOH   HOH A . 
C 3 HOH   117 617 88  HOH   HOH A . 
C 3 HOH   118 618 141 HOH   HOH A . 
C 3 HOH   119 619 5   HOH   HOH A . 
C 3 HOH   120 620 44  HOH   HOH A . 
C 3 HOH   121 621 126 HOH   HOH A . 
C 3 HOH   122 622 71  HOH   HOH A . 
C 3 HOH   123 623 74  HOH   HOH A . 
C 3 HOH   124 624 106 HOH   HOH A . 
C 3 HOH   125 625 33  HOH   HOH A . 
C 3 HOH   126 626 10  HOH   HOH A . 
C 3 HOH   127 627 12  HOH   HOH A . 
C 3 HOH   128 628 165 HOH   HOH A . 
C 3 HOH   129 629 1   HOH   HOH A . 
C 3 HOH   130 630 93  HOH   HOH A . 
C 3 HOH   131 631 86  HOH   HOH A . 
C 3 HOH   132 632 145 HOH   HOH A . 
C 3 HOH   133 633 107 HOH   HOH A . 
C 3 HOH   134 634 32  HOH   HOH A . 
C 3 HOH   135 635 170 HOH   HOH A . 
C 3 HOH   136 636 85  HOH   HOH A . 
C 3 HOH   137 637 20  HOH   HOH A . 
C 3 HOH   138 638 144 HOH   HOH A . 
C 3 HOH   139 639 41  HOH   HOH A . 
C 3 HOH   140 640 89  HOH   HOH A . 
C 3 HOH   141 641 15  HOH   HOH A . 
C 3 HOH   142 642 164 HOH   HOH A . 
C 3 HOH   143 643 92  HOH   HOH A . 
C 3 HOH   144 644 101 HOH   HOH A . 
C 3 HOH   145 645 104 HOH   HOH A . 
C 3 HOH   146 646 266 HOH   HOH A . 
C 3 HOH   147 647 133 HOH   HOH A . 
C 3 HOH   148 648 47  HOH   HOH A . 
C 3 HOH   149 649 169 HOH   HOH A . 
C 3 HOH   150 650 99  HOH   HOH A . 
C 3 HOH   151 651 220 HOH   HOH A . 
C 3 HOH   152 652 23  HOH   HOH A . 
C 3 HOH   153 653 194 HOH   HOH A . 
C 3 HOH   154 654 230 HOH   HOH A . 
C 3 HOH   155 655 9   HOH   HOH A . 
C 3 HOH   156 656 37  HOH   HOH A . 
C 3 HOH   157 657 215 HOH   HOH A . 
C 3 HOH   158 658 121 HOH   HOH A . 
C 3 HOH   159 659 143 HOH   HOH A . 
C 3 HOH   160 660 116 HOH   HOH A . 
C 3 HOH   161 661 147 HOH   HOH A . 
C 3 HOH   162 662 224 HOH   HOH A . 
C 3 HOH   163 663 132 HOH   HOH A . 
C 3 HOH   164 664 151 HOH   HOH A . 
C 3 HOH   165 665 59  HOH   HOH A . 
C 3 HOH   166 666 197 HOH   HOH A . 
C 3 HOH   167 667 252 HOH   HOH A . 
C 3 HOH   168 668 80  HOH   HOH A . 
C 3 HOH   169 669 161 HOH   HOH A . 
C 3 HOH   170 670 158 HOH   HOH A . 
C 3 HOH   171 671 14  HOH   HOH A . 
C 3 HOH   172 672 207 HOH   HOH A . 
C 3 HOH   173 673 142 HOH   HOH A . 
C 3 HOH   174 674 156 HOH   HOH A . 
C 3 HOH   175 675 182 HOH   HOH A . 
C 3 HOH   176 676 167 HOH   HOH A . 
C 3 HOH   177 677 127 HOH   HOH A . 
C 3 HOH   178 678 69  HOH   HOH A . 
C 3 HOH   179 679 7   HOH   HOH A . 
C 3 HOH   180 680 105 HOH   HOH A . 
C 3 HOH   181 681 115 HOH   HOH A . 
C 3 HOH   182 682 30  HOH   HOH A . 
C 3 HOH   183 683 117 HOH   HOH A . 
C 3 HOH   184 684 45  HOH   HOH A . 
C 3 HOH   185 685 251 HOH   HOH A . 
C 3 HOH   186 686 241 HOH   HOH A . 
C 3 HOH   187 687 150 HOH   HOH A . 
C 3 HOH   188 688 125 HOH   HOH A . 
C 3 HOH   189 689 34  HOH   HOH A . 
C 3 HOH   190 690 100 HOH   HOH A . 
C 3 HOH   191 691 242 HOH   HOH A . 
C 3 HOH   192 692 218 HOH   HOH A . 
C 3 HOH   193 693 199 HOH   HOH A . 
C 3 HOH   194 694 229 HOH   HOH A . 
C 3 HOH   195 695 196 HOH   HOH A . 
C 3 HOH   196 696 83  HOH   HOH A . 
C 3 HOH   197 697 198 HOH   HOH A . 
C 3 HOH   198 698 216 HOH   HOH A . 
C 3 HOH   199 699 192 HOH   HOH A . 
C 3 HOH   200 700 257 HOH   HOH A . 
C 3 HOH   201 701 247 HOH   HOH A . 
C 3 HOH   202 702 149 HOH   HOH A . 
C 3 HOH   203 703 186 HOH   HOH A . 
C 3 HOH   204 704 90  HOH   HOH A . 
C 3 HOH   205 705 219 HOH   HOH A . 
C 3 HOH   206 706 110 HOH   HOH A . 
C 3 HOH   207 707 70  HOH   HOH A . 
C 3 HOH   208 708 160 HOH   HOH A . 
C 3 HOH   209 709 203 HOH   HOH A . 
C 3 HOH   210 710 267 HOH   HOH A . 
C 3 HOH   211 711 56  HOH   HOH A . 
C 3 HOH   212 712 223 HOH   HOH A . 
C 3 HOH   213 713 261 HOH   HOH A . 
C 3 HOH   214 714 211 HOH   HOH A . 
C 3 HOH   215 715 245 HOH   HOH A . 
C 3 HOH   216 716 168 HOH   HOH A . 
C 3 HOH   217 717 231 HOH   HOH A . 
C 3 HOH   218 718 152 HOH   HOH A . 
C 3 HOH   219 719 54  HOH   HOH A . 
C 3 HOH   220 720 262 HOH   HOH A . 
C 3 HOH   221 721 135 HOH   HOH A . 
C 3 HOH   222 722 272 HOH   HOH A . 
C 3 HOH   223 723 66  HOH   HOH A . 
C 3 HOH   224 724 175 HOH   HOH A . 
C 3 HOH   225 725 78  HOH   HOH A . 
C 3 HOH   226 726 191 HOH   HOH A . 
C 3 HOH   227 727 81  HOH   HOH A . 
C 3 HOH   228 728 102 HOH   HOH A . 
C 3 HOH   229 729 193 HOH   HOH A . 
C 3 HOH   230 730 217 HOH   HOH A . 
C 3 HOH   231 731 240 HOH   HOH A . 
C 3 HOH   232 732 248 HOH   HOH A . 
C 3 HOH   233 733 250 HOH   HOH A . 
C 3 HOH   234 734 113 HOH   HOH A . 
C 3 HOH   235 735 195 HOH   HOH A . 
C 3 HOH   236 736 233 HOH   HOH A . 
C 3 HOH   237 737 62  HOH   HOH A . 
C 3 HOH   238 738 187 HOH   HOH A . 
C 3 HOH   239 739 228 HOH   HOH A . 
C 3 HOH   240 740 214 HOH   HOH A . 
C 3 HOH   241 741 185 HOH   HOH A . 
C 3 HOH   242 742 239 HOH   HOH A . 
C 3 HOH   243 743 246 HOH   HOH A . 
C 3 HOH   244 744 138 HOH   HOH A . 
C 3 HOH   245 745 253 HOH   HOH A . 
C 3 HOH   246 746 255 HOH   HOH A . 
C 3 HOH   247 747 129 HOH   HOH A . 
C 3 HOH   248 748 112 HOH   HOH A . 
C 3 HOH   249 749 131 HOH   HOH A . 
C 3 HOH   250 750 177 HOH   HOH A . 
C 3 HOH   251 751 258 HOH   HOH A . 
C 3 HOH   252 752 179 HOH   HOH A . 
C 3 HOH   253 753 243 HOH   HOH A . 
C 3 HOH   254 754 209 HOH   HOH A . 
C 3 HOH   255 755 61  HOH   HOH A . 
C 3 HOH   256 756 190 HOH   HOH A . 
C 3 HOH   257 757 36  HOH   HOH A . 
C 3 HOH   258 758 189 HOH   HOH A . 
C 3 HOH   259 759 98  HOH   HOH A . 
C 3 HOH   260 760 181 HOH   HOH A . 
C 3 HOH   261 761 249 HOH   HOH A . 
C 3 HOH   262 762 148 HOH   HOH A . 
C 3 HOH   263 763 235 HOH   HOH A . 
C 3 HOH   264 764 162 HOH   HOH A . 
C 3 HOH   265 765 271 HOH   HOH A . 
C 3 HOH   266 766 140 HOH   HOH A . 
C 3 HOH   267 767 184 HOH   HOH A . 
C 3 HOH   268 768 139 HOH   HOH A . 
C 3 HOH   269 769 237 HOH   HOH A . 
C 3 HOH   270 770 244 HOH   HOH A . 
C 3 HOH   271 771 146 HOH   HOH A . 
C 3 HOH   272 772 173 HOH   HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement        ? ? ? ? ? ? ? ? ? ? ? PHENIX         ? ? ? 1.18.2_3874 1 
? 'data extraction' ? ? ? ? ? ? ? ? ? ? ? PDB_EXTRACT    ? ? ? .           2 
? 'data reduction'  ? ? ? ? ? ? ? ? ? ? ? 'PROTEUM PLUS' ? ? ? .           3 
? 'data scaling'    ? ? ? ? ? ? ? ? ? ? ? Aimless        ? ? ? .           4 
? phasing           ? ? ? ? ? ? ? ? ? ? ? PHENIX         ? ? ? .           5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   97.246 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BTK 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     51.600 
_cell.length_a_esd                 ? 
_cell.length_b                     80.363 
_cell.length_b_esd                 ? 
_cell.length_c                     89.894 
_cell.length_c_esd                 ? 
_cell.volume                       369784.979 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BTK 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y (x,y,-x+z)' 
_symmetry.space_group_name_H-M             'I 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BTK 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.77 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          55.54 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;0.2 M Ammonium phosphate dibasic, 17%
W/v PEG3350, pH8.0
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            289 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     120 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'Bruker PHOTON II' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-01-18 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.54301 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'ROTATING ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        'RIGAKU MICROMAX-002' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.54301 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          13.49 
_reflns.entry_id                                       9BTK 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.79 
_reflns.d_resolution_low                               24.40 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     34108 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           98.55 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          0.899 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.79 
_reflns_shell.d_res_low                                     1.864 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3200 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  1.0 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               23.30 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9BTK 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.79 
_refine.ls_d_res_low                             24.40 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     33832 
_refine.ls_number_reflns_R_free                  1666 
_refine.ls_number_reflns_R_work                  32166 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.54 
_refine.ls_percent_reflns_R_free                 4.92 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2156 
_refine.ls_R_factor_R_free                       0.2492 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2139 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 25.9976 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2212 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.79 
_refine_hist.d_res_low                        24.40 
_refine_hist.number_atoms_solvent             272 
_refine_hist.number_atoms_total               2677 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2367 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         38 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0183  ? 2461 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 2.2371  ? 3354 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.1128  ? 376  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0115  ? 432  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 12.4670 ? 331  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.79 1.84  . . 107 2547 92.83  . . . . 0.3308 . . . . . . . . . . . 0.3403 
'X-RAY DIFFRACTION' 1.84 1.90  . . 144 2674 99.47  . . . . 0.2933 . . . . . . . . . . . 0.3341 
'X-RAY DIFFRACTION' 1.90 1.97  . . 139 2704 99.96  . . . . 0.2555 . . . . . . . . . . . 0.3136 
'X-RAY DIFFRACTION' 1.97 2.05  . . 147 2730 100.00 . . . . 0.2348 . . . . . . . . . . . 0.2439 
'X-RAY DIFFRACTION' 2.05 2.14  . . 152 2671 99.89  . . . . 0.2282 . . . . . . . . . . . 0.2537 
'X-RAY DIFFRACTION' 2.14 2.25  . . 136 2721 99.90  . . . . 0.2227 . . . . . . . . . . . 0.2733 
'X-RAY DIFFRACTION' 2.25 2.40  . . 144 2668 99.65  . . . . 0.2198 . . . . . . . . . . . 0.2632 
'X-RAY DIFFRACTION' 2.40 2.58  . . 142 2697 98.37  . . . . 0.2282 . . . . . . . . . . . 0.2773 
'X-RAY DIFFRACTION' 2.58 2.84  . . 127 2658 97.62  . . . . 0.2321 . . . . . . . . . . . 0.2642 
'X-RAY DIFFRACTION' 2.84 3.25  . . 132 2643 96.79  . . . . 0.2111 . . . . . . . . . . . 0.2483 
'X-RAY DIFFRACTION' 3.25 4.09  . . 146 2686 98.57  . . . . 0.1867 . . . . . . . . . . . 0.2411 
'X-RAY DIFFRACTION' 4.09 24.40 . . 150 2767 99.52  . . . . 0.1522 . . . . . . . . . . . 0.1743 
# 
_struct.entry_id                     9BTK 
_struct.title                        'Structure of the SARS-CoV-2 main protease in complex with inhibitor YR-C-108T' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BTK 
_struct_keywords.text            'main protease, VIRAL PROTEIN, Hydrolase' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN, Hydrolase' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1AB_SARS2 
_struct_ref.pdbx_db_accession          P0DTD1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_struct_ref.pdbx_align_begin           3264 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9BTK 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 306 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P0DTD1 
_struct_ref_seq.db_align_beg                  3264 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3569 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       306 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 5200  ? 
1 MORE         -11   ? 
1 'SSA (A^2)'  24500 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z     1.0000000000  0.0000000000 0.0000000000 0.0000000000   0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000 
2 'crystal symmetry operation' 2_455 -x-1,y,-z -1.0000000000 0.0000000000 0.0000000000 -51.6000000000 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 10  ? GLY A 15  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 41  ? CYS A 44  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 ASN A 53  ? ARG A 60  ? ASN A 53  ARG A 60  1 ? 8  
HELX_P HELX_P4  AA4 SER A 62  ? HIS A 64  ? SER A 62  HIS A 64  5 ? 3  
HELX_P HELX_P5  AA5 ILE A 200 ? ASN A 214 ? ILE A 200 ASN A 214 1 ? 15 
HELX_P HELX_P6  AA6 THR A 226 ? TYR A 237 ? THR A 226 TYR A 237 1 ? 12 
HELX_P HELX_P7  AA7 THR A 243 ? LEU A 250 ? THR A 243 LEU A 250 1 ? 8  
HELX_P HELX_P8  AA8 LEU A 250 ? GLY A 258 ? LEU A 250 GLY A 258 1 ? 9  
HELX_P HELX_P9  AA9 ALA A 260 ? GLY A 275 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P10 AB1 THR A 292 ? CYS A 300 ? THR A 292 CYS A 300 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            covale1 
_struct_conn.conn_type_id                  covale 
_struct_conn.pdbx_leaving_atom_flag        none 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            145 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           B 
_struct_conn.ptnr2_label_comp_id           A1ASG 
_struct_conn.ptnr2_label_seq_id            . 
_struct_conn.ptnr2_label_atom_id           C11 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             145 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            A1ASG 
_struct_conn.ptnr2_auth_seq_id             401 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               1.818 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      A1ASG 
_pdbx_modification_feature.label_asym_id                      B 
_pdbx_modification_feature.label_seq_id                       . 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      145 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       A1ASG 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        401 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       145 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               C11 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                CYS 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        A1ASG 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Covalent chemical modification' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 73  ? LEU A 75  ? VAL A 73  LEU A 75  
AA1 2 PHE A 66  ? ALA A 70  ? PHE A 66  ALA A 70  
AA1 3 MET A 17  ? CYS A 22  ? MET A 17  CYS A 22  
AA1 4 THR A 25  ? LEU A 32  ? THR A 25  LEU A 32  
AA1 5 VAL A 35  ? PRO A 39  ? VAL A 35  PRO A 39  
AA1 6 VAL A 86  ? VAL A 91  ? VAL A 86  VAL A 91  
AA1 7 VAL A 77  ? GLN A 83  ? VAL A 77  GLN A 83  
AA2 1 TYR A 101 ? PHE A 103 ? TYR A 101 PHE A 103 
AA2 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA2 3 VAL A 148 ? ASP A 153 ? VAL A 148 ASP A 153 
AA2 4 THR A 111 ? TYR A 118 ? THR A 111 TYR A 118 
AA2 5 SER A 121 ? ALA A 129 ? SER A 121 ALA A 129 
AA3 1 TYR A 101 ? PHE A 103 ? TYR A 101 PHE A 103 
AA3 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA3 3 HIS A 172 ? THR A 175 ? HIS A 172 THR A 175 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL A 73  ? O VAL A 73  N ALA A 70  ? N ALA A 70  
AA1 2 3 O LEU A 67  ? O LEU A 67  N THR A 21  ? N THR A 21  
AA1 3 4 N VAL A 20  ? N VAL A 20  O LEU A 27  ? O LEU A 27  
AA1 4 5 N LEU A 30  ? N LEU A 30  O TYR A 37  ? O TYR A 37  
AA1 5 6 N CYS A 38  ? N CYS A 38  O LEU A 87  ? O LEU A 87  
AA1 6 7 O LYS A 90  ? O LYS A 90  N ILE A 78  ? N ILE A 78  
AA2 1 2 N LYS A 102 ? N LYS A 102 O PHE A 159 ? O PHE A 159 
AA2 2 3 O SER A 158 ? O SER A 158 N ASN A 151 ? N ASN A 151 
AA2 3 4 O PHE A 150 ? O PHE A 150 N SER A 113 ? N SER A 113 
AA2 4 5 N VAL A 114 ? N VAL A 114 O TYR A 126 ? O TYR A 126 
AA3 1 2 N LYS A 102 ? N LYS A 102 O PHE A 159 ? O PHE A 159 
AA3 2 3 N MET A 162 ? N MET A 162 O THR A 175 ? O THR A 175 
# 
_pdbx_entry_details.entry_id                   9BTK 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1  1 O   A CYS 300 ? ? O A HOH 501 ? ? 1.83 
2  1 OE2 A GLU 240 ? ? O A HOH 502 ? ? 1.83 
3  1 NH2 A ARG 298 ? ? O A HOH 503 ? ? 1.84 
4  1 O   A HOH 705 ? ? O A HOH 714 ? ? 1.87 
5  1 O   A HOH 694 ? ? O A HOH 699 ? ? 1.87 
6  1 N   A THR 190 ? ? O A HOH 504 ? ? 1.95 
7  1 O   A HOH 650 ? ? O A HOH 717 ? ? 1.95 
8  1 O   A HOH 586 ? ? O A HOH 642 ? ? 2.01 
9  1 O   A HOH 534 ? ? O A HOH 710 ? ? 2.03 
10 1 O   A HOH 555 ? ? O A HOH 557 ? ? 2.05 
11 1 C   A GLN 189 ? ? O A HOH 504 ? ? 2.06 
12 1 O   A GLN 189 ? ? O A HOH 504 ? ? 2.06 
13 1 O   A HOH 505 ? ? O A HOH 734 ? ? 2.09 
14 1 NE2 A GLN 83  ? ? O A HOH 505 ? ? 2.09 
15 1 O   A HOH 654 ? ? O A HOH 728 ? ? 2.09 
16 1 O   A PRO 184 ? ? O A HOH 506 ? ? 2.14 
17 1 OE1 A GLU 240 ? ? O A HOH 507 ? ? 2.14 
# 
loop_
_pdbx_validate_symm_contact.id 
_pdbx_validate_symm_contact.PDB_model_num 
_pdbx_validate_symm_contact.auth_atom_id_1 
_pdbx_validate_symm_contact.auth_asym_id_1 
_pdbx_validate_symm_contact.auth_comp_id_1 
_pdbx_validate_symm_contact.auth_seq_id_1 
_pdbx_validate_symm_contact.PDB_ins_code_1 
_pdbx_validate_symm_contact.label_alt_id_1 
_pdbx_validate_symm_contact.site_symmetry_1 
_pdbx_validate_symm_contact.auth_atom_id_2 
_pdbx_validate_symm_contact.auth_asym_id_2 
_pdbx_validate_symm_contact.auth_comp_id_2 
_pdbx_validate_symm_contact.auth_seq_id_2 
_pdbx_validate_symm_contact.PDB_ins_code_2 
_pdbx_validate_symm_contact.label_alt_id_2 
_pdbx_validate_symm_contact.site_symmetry_2 
_pdbx_validate_symm_contact.dist 
1 1 O A HOH 734 ? ? 1_555 O A HOH 759 ? ? 2_555 1.31 
2 1 O A HOH 664 ? ? 1_555 O A HOH 734 ? ? 2_555 1.94 
3 1 O A HOH 538 ? ? 1_555 O A HOH 721 ? ? 2_555 2.11 
# 
loop_
_pdbx_validate_rmsd_bond.id 
_pdbx_validate_rmsd_bond.PDB_model_num 
_pdbx_validate_rmsd_bond.auth_atom_id_1 
_pdbx_validate_rmsd_bond.auth_asym_id_1 
_pdbx_validate_rmsd_bond.auth_comp_id_1 
_pdbx_validate_rmsd_bond.auth_seq_id_1 
_pdbx_validate_rmsd_bond.PDB_ins_code_1 
_pdbx_validate_rmsd_bond.label_alt_id_1 
_pdbx_validate_rmsd_bond.auth_atom_id_2 
_pdbx_validate_rmsd_bond.auth_asym_id_2 
_pdbx_validate_rmsd_bond.auth_comp_id_2 
_pdbx_validate_rmsd_bond.auth_seq_id_2 
_pdbx_validate_rmsd_bond.PDB_ins_code_2 
_pdbx_validate_rmsd_bond.label_alt_id_2 
_pdbx_validate_rmsd_bond.bond_value 
_pdbx_validate_rmsd_bond.bond_target_value 
_pdbx_validate_rmsd_bond.bond_deviation 
_pdbx_validate_rmsd_bond.bond_standard_deviation 
_pdbx_validate_rmsd_bond.linker_flag 
1 1 CB A LYS 5   ? ? CG A LYS 5   ? ? 1.782 1.521 0.261  0.027 N 
2 1 CD A LYS 5   ? ? CE A LYS 5   ? ? 1.774 1.508 0.266  0.025 N 
3 1 CE A LYS 5   ? ? NZ A LYS 5   ? ? 1.818 1.486 0.332  0.025 N 
4 1 CB A GLN 74  ? ? CG A GLN 74  ? ? 1.687 1.521 0.166  0.027 N 
5 1 CB A CYS 128 ? ? SG A CYS 128 ? ? 1.679 1.812 -0.133 0.016 N 
6 1 CG A ARG 298 ? ? CD A ARG 298 ? ? 1.705 1.515 0.190  0.025 N 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1  1 CB A LYS 5   ? ? CA A LYS 5   ? ? C   A LYS 5   ? ? 123.55 110.40 13.15  2.00 N 
2  1 CB A LYS 5   ? ? CG A LYS 5   ? ? CD  A LYS 5   ? ? 79.39  111.60 -32.21 2.60 N 
3  1 CG A LYS 5   ? ? CD A LYS 5   ? ? CE  A LYS 5   ? ? 131.14 111.90 19.24  3.00 N 
4  1 CA A LEU 67  ? ? CB A LEU 67  ? ? CG  A LEU 67  ? ? 130.17 115.30 14.87  2.30 N 
5  1 CA A GLN 74  ? ? CB A GLN 74  ? ? CG  A GLN 74  ? ? 90.46  113.40 -22.94 2.20 N 
6  1 CG A GLN 74  ? ? CD A GLN 74  ? ? OE1 A GLN 74  ? ? 179.93 121.60 58.33  2.00 N 
7  1 CG A GLN 74  ? ? CD A GLN 74  ? ? NE2 A GLN 74  ? ? 71.41  116.70 -45.29 2.40 N 
8  1 NE A ARG 188 ? ? CZ A ARG 188 ? ? NH2 A ARG 188 ? ? 117.07 120.30 -3.23  0.50 N 
9  1 CG A ARG 298 ? ? CD A ARG 298 ? ? NE  A ARG 298 ? ? 132.17 111.80 20.37  2.10 N 
10 1 CD A ARG 298 ? ? NE A ARG 298 ? ? CZ  A ARG 298 ? ? 135.50 123.60 11.90  1.40 N 
11 1 NE A ARG 298 ? ? CZ A ARG 298 ? ? NH1 A ARG 298 ? ? 124.07 120.30 3.77   0.50 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 33  ? ? 50.62   -136.57 
2 1 MET A 49  ? ? -69.83  5.62    
3 1 GLN A 74  ? ? 6.64    98.42   
4 1 ASN A 84  ? ? 50.58   -121.66 
5 1 ASN A 142 ? ? -39.84  133.58  
6 1 TYR A 154 ? ? 43.92   -110.06 
7 1 SER A 301 ? ? -149.97 -30.38  
# 
_pdbx_validate_peptide_omega.id               1 
_pdbx_validate_peptide_omega.PDB_model_num    1 
_pdbx_validate_peptide_omega.auth_comp_id_1   VAL 
_pdbx_validate_peptide_omega.auth_asym_id_1   A 
_pdbx_validate_peptide_omega.auth_seq_id_1    73 
_pdbx_validate_peptide_omega.PDB_ins_code_1   ? 
_pdbx_validate_peptide_omega.label_alt_id_1   ? 
_pdbx_validate_peptide_omega.auth_comp_id_2   GLN 
_pdbx_validate_peptide_omega.auth_asym_id_2   A 
_pdbx_validate_peptide_omega.auth_seq_id_2    74 
_pdbx_validate_peptide_omega.PDB_ins_code_2   ? 
_pdbx_validate_peptide_omega.label_alt_id_2   ? 
_pdbx_validate_peptide_omega.omega            114.02 
# 
_pdbx_validate_planes.id              1 
_pdbx_validate_planes.PDB_model_num   1 
_pdbx_validate_planes.auth_comp_id    ARG 
_pdbx_validate_planes.auth_asym_id    A 
_pdbx_validate_planes.auth_seq_id     298 
_pdbx_validate_planes.PDB_ins_code    ? 
_pdbx_validate_planes.label_alt_id    ? 
_pdbx_validate_planes.rmsd            0.099 
_pdbx_validate_planes.type            'SIDE CHAIN' 
# 
_pdbx_validate_main_chain_plane.id                       1 
_pdbx_validate_main_chain_plane.PDB_model_num            1 
_pdbx_validate_main_chain_plane.auth_comp_id             LYS 
_pdbx_validate_main_chain_plane.auth_asym_id             A 
_pdbx_validate_main_chain_plane.auth_seq_id              5 
_pdbx_validate_main_chain_plane.PDB_ins_code             ? 
_pdbx_validate_main_chain_plane.label_alt_id             ? 
_pdbx_validate_main_chain_plane.improper_torsion_angle   10.38 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 577 ? C HOH . 
2 1 A HOH 637 ? C HOH . 
3 1 A HOH 671 ? C HOH . 
4 1 A HOH 754 ? C HOH . 
5 1 A HOH 760 ? C HOH . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z               
2 -x,y,-z             
3 x+1/2,y+1/2,z+1/2   
4 -x+1/2,y+1/2,-z+1/2 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1ASG N1   N Y N 1   
A1ASG N3   N N N 2   
A1ASG C4   C Y N 3   
A1ASG C5   C Y N 4   
A1ASG C6   C Y N 5   
A1ASG C7   C Y N 6   
A1ASG C8   C Y N 7   
A1ASG C10  C N S 8   
A1ASG C13  C N S 9   
A1ASG C15  C N S 10  
A1ASG C17  C N N 11  
A1ASG C20  C N N 12  
A1ASG C21  C N R 13  
A1ASG C22  C N N 14  
A1ASG C24  C N N 15  
A1ASG C26  C N N 16  
A1ASG C1   C Y N 17  
A1ASG C11  C N N 18  
A1ASG C12  C N N 19  
A1ASG C14  C N R 20  
A1ASG C16  C N N 21  
A1ASG C18  C N N 22  
A1ASG C19  C N N 23  
A1ASG C2   C Y N 24  
A1ASG C23  C N N 25  
A1ASG C25  C N N 26  
A1ASG C27  C N N 27  
A1ASG C3   C Y N 28  
A1ASG C9   C Y N 29  
A1ASG F1   F N N 30  
A1ASG F2   F N N 31  
A1ASG F3   F N N 32  
A1ASG N2   N N N 33  
A1ASG N4   N N N 34  
A1ASG N5   N N N 35  
A1ASG O1   O N N 36  
A1ASG O2   O N N 37  
A1ASG O3   O N N 38  
A1ASG H10  H N N 39  
A1ASG H2   H N N 40  
A1ASG H3   H N N 41  
A1ASG H4   H N N 42  
A1ASG H5   H N N 43  
A1ASG H7   H N N 44  
A1ASG H11  H N N 45  
A1ASG H13  H N N 46  
A1ASG H22  H N N 47  
A1ASG H28  H N N 48  
A1ASG H29  H N N 49  
A1ASG H27  H N N 50  
A1ASG H9   H N N 51  
A1ASG H12  H N N 52  
A1ASG H14  H N N 53  
A1ASG H15  H N N 54  
A1ASG H17  H N N 55  
A1ASG H18  H N N 56  
A1ASG H16  H N N 57  
A1ASG H21  H N N 58  
A1ASG H19  H N N 59  
A1ASG H20  H N N 60  
A1ASG H25  H N N 61  
A1ASG H24  H N N 62  
A1ASG H26  H N N 63  
A1ASG H31  H N N 64  
A1ASG H30  H N N 65  
A1ASG H32  H N N 66  
A1ASG H1   H N N 67  
A1ASG H6   H N N 68  
A1ASG H8   H N N 69  
A1ASG H23  H N N 70  
ALA   N    N N N 71  
ALA   CA   C N S 72  
ALA   C    C N N 73  
ALA   O    O N N 74  
ALA   CB   C N N 75  
ALA   OXT  O N N 76  
ALA   H    H N N 77  
ALA   H2   H N N 78  
ALA   HA   H N N 79  
ALA   HB1  H N N 80  
ALA   HB2  H N N 81  
ALA   HB3  H N N 82  
ALA   HXT  H N N 83  
ARG   N    N N N 84  
ARG   CA   C N S 85  
ARG   C    C N N 86  
ARG   O    O N N 87  
ARG   CB   C N N 88  
ARG   CG   C N N 89  
ARG   CD   C N N 90  
ARG   NE   N N N 91  
ARG   CZ   C N N 92  
ARG   NH1  N N N 93  
ARG   NH2  N N N 94  
ARG   OXT  O N N 95  
ARG   H    H N N 96  
ARG   H2   H N N 97  
ARG   HA   H N N 98  
ARG   HB2  H N N 99  
ARG   HB3  H N N 100 
ARG   HG2  H N N 101 
ARG   HG3  H N N 102 
ARG   HD2  H N N 103 
ARG   HD3  H N N 104 
ARG   HE   H N N 105 
ARG   HH11 H N N 106 
ARG   HH12 H N N 107 
ARG   HH21 H N N 108 
ARG   HH22 H N N 109 
ARG   HXT  H N N 110 
ASN   N    N N N 111 
ASN   CA   C N S 112 
ASN   C    C N N 113 
ASN   O    O N N 114 
ASN   CB   C N N 115 
ASN   CG   C N N 116 
ASN   OD1  O N N 117 
ASN   ND2  N N N 118 
ASN   OXT  O N N 119 
ASN   H    H N N 120 
ASN   H2   H N N 121 
ASN   HA   H N N 122 
ASN   HB2  H N N 123 
ASN   HB3  H N N 124 
ASN   HD21 H N N 125 
ASN   HD22 H N N 126 
ASN   HXT  H N N 127 
ASP   N    N N N 128 
ASP   CA   C N S 129 
ASP   C    C N N 130 
ASP   O    O N N 131 
ASP   CB   C N N 132 
ASP   CG   C N N 133 
ASP   OD1  O N N 134 
ASP   OD2  O N N 135 
ASP   OXT  O N N 136 
ASP   H    H N N 137 
ASP   H2   H N N 138 
ASP   HA   H N N 139 
ASP   HB2  H N N 140 
ASP   HB3  H N N 141 
ASP   HD2  H N N 142 
ASP   HXT  H N N 143 
CYS   N    N N N 144 
CYS   CA   C N R 145 
CYS   C    C N N 146 
CYS   O    O N N 147 
CYS   CB   C N N 148 
CYS   SG   S N N 149 
CYS   OXT  O N N 150 
CYS   H    H N N 151 
CYS   H2   H N N 152 
CYS   HA   H N N 153 
CYS   HB2  H N N 154 
CYS   HB3  H N N 155 
CYS   HG   H N N 156 
CYS   HXT  H N N 157 
GLN   N    N N N 158 
GLN   CA   C N S 159 
GLN   C    C N N 160 
GLN   O    O N N 161 
GLN   CB   C N N 162 
GLN   CG   C N N 163 
GLN   CD   C N N 164 
GLN   OE1  O N N 165 
GLN   NE2  N N N 166 
GLN   OXT  O N N 167 
GLN   H    H N N 168 
GLN   H2   H N N 169 
GLN   HA   H N N 170 
GLN   HB2  H N N 171 
GLN   HB3  H N N 172 
GLN   HG2  H N N 173 
GLN   HG3  H N N 174 
GLN   HE21 H N N 175 
GLN   HE22 H N N 176 
GLN   HXT  H N N 177 
GLU   N    N N N 178 
GLU   CA   C N S 179 
GLU   C    C N N 180 
GLU   O    O N N 181 
GLU   CB   C N N 182 
GLU   CG   C N N 183 
GLU   CD   C N N 184 
GLU   OE1  O N N 185 
GLU   OE2  O N N 186 
GLU   OXT  O N N 187 
GLU   H    H N N 188 
GLU   H2   H N N 189 
GLU   HA   H N N 190 
GLU   HB2  H N N 191 
GLU   HB3  H N N 192 
GLU   HG2  H N N 193 
GLU   HG3  H N N 194 
GLU   HE2  H N N 195 
GLU   HXT  H N N 196 
GLY   N    N N N 197 
GLY   CA   C N N 198 
GLY   C    C N N 199 
GLY   O    O N N 200 
GLY   OXT  O N N 201 
GLY   H    H N N 202 
GLY   H2   H N N 203 
GLY   HA2  H N N 204 
GLY   HA3  H N N 205 
GLY   HXT  H N N 206 
HIS   N    N N N 207 
HIS   CA   C N S 208 
HIS   C    C N N 209 
HIS   O    O N N 210 
HIS   CB   C N N 211 
HIS   CG   C Y N 212 
HIS   ND1  N Y N 213 
HIS   CD2  C Y N 214 
HIS   CE1  C Y N 215 
HIS   NE2  N Y N 216 
HIS   OXT  O N N 217 
HIS   H    H N N 218 
HIS   H2   H N N 219 
HIS   HA   H N N 220 
HIS   HB2  H N N 221 
HIS   HB3  H N N 222 
HIS   HD1  H N N 223 
HIS   HD2  H N N 224 
HIS   HE1  H N N 225 
HIS   HE2  H N N 226 
HIS   HXT  H N N 227 
HOH   O    O N N 228 
HOH   H1   H N N 229 
HOH   H2   H N N 230 
ILE   N    N N N 231 
ILE   CA   C N S 232 
ILE   C    C N N 233 
ILE   O    O N N 234 
ILE   CB   C N S 235 
ILE   CG1  C N N 236 
ILE   CG2  C N N 237 
ILE   CD1  C N N 238 
ILE   OXT  O N N 239 
ILE   H    H N N 240 
ILE   H2   H N N 241 
ILE   HA   H N N 242 
ILE   HB   H N N 243 
ILE   HG12 H N N 244 
ILE   HG13 H N N 245 
ILE   HG21 H N N 246 
ILE   HG22 H N N 247 
ILE   HG23 H N N 248 
ILE   HD11 H N N 249 
ILE   HD12 H N N 250 
ILE   HD13 H N N 251 
ILE   HXT  H N N 252 
LEU   N    N N N 253 
LEU   CA   C N S 254 
LEU   C    C N N 255 
LEU   O    O N N 256 
LEU   CB   C N N 257 
LEU   CG   C N N 258 
LEU   CD1  C N N 259 
LEU   CD2  C N N 260 
LEU   OXT  O N N 261 
LEU   H    H N N 262 
LEU   H2   H N N 263 
LEU   HA   H N N 264 
LEU   HB2  H N N 265 
LEU   HB3  H N N 266 
LEU   HG   H N N 267 
LEU   HD11 H N N 268 
LEU   HD12 H N N 269 
LEU   HD13 H N N 270 
LEU   HD21 H N N 271 
LEU   HD22 H N N 272 
LEU   HD23 H N N 273 
LEU   HXT  H N N 274 
LYS   N    N N N 275 
LYS   CA   C N S 276 
LYS   C    C N N 277 
LYS   O    O N N 278 
LYS   CB   C N N 279 
LYS   CG   C N N 280 
LYS   CD   C N N 281 
LYS   CE   C N N 282 
LYS   NZ   N N N 283 
LYS   OXT  O N N 284 
LYS   H    H N N 285 
LYS   H2   H N N 286 
LYS   HA   H N N 287 
LYS   HB2  H N N 288 
LYS   HB3  H N N 289 
LYS   HG2  H N N 290 
LYS   HG3  H N N 291 
LYS   HD2  H N N 292 
LYS   HD3  H N N 293 
LYS   HE2  H N N 294 
LYS   HE3  H N N 295 
LYS   HZ1  H N N 296 
LYS   HZ2  H N N 297 
LYS   HZ3  H N N 298 
LYS   HXT  H N N 299 
MET   N    N N N 300 
MET   CA   C N S 301 
MET   C    C N N 302 
MET   O    O N N 303 
MET   CB   C N N 304 
MET   CG   C N N 305 
MET   SD   S N N 306 
MET   CE   C N N 307 
MET   OXT  O N N 308 
MET   H    H N N 309 
MET   H2   H N N 310 
MET   HA   H N N 311 
MET   HB2  H N N 312 
MET   HB3  H N N 313 
MET   HG2  H N N 314 
MET   HG3  H N N 315 
MET   HE1  H N N 316 
MET   HE2  H N N 317 
MET   HE3  H N N 318 
MET   HXT  H N N 319 
PHE   N    N N N 320 
PHE   CA   C N S 321 
PHE   C    C N N 322 
PHE   O    O N N 323 
PHE   CB   C N N 324 
PHE   CG   C Y N 325 
PHE   CD1  C Y N 326 
PHE   CD2  C Y N 327 
PHE   CE1  C Y N 328 
PHE   CE2  C Y N 329 
PHE   CZ   C Y N 330 
PHE   OXT  O N N 331 
PHE   H    H N N 332 
PHE   H2   H N N 333 
PHE   HA   H N N 334 
PHE   HB2  H N N 335 
PHE   HB3  H N N 336 
PHE   HD1  H N N 337 
PHE   HD2  H N N 338 
PHE   HE1  H N N 339 
PHE   HE2  H N N 340 
PHE   HZ   H N N 341 
PHE   HXT  H N N 342 
PRO   N    N N N 343 
PRO   CA   C N S 344 
PRO   C    C N N 345 
PRO   O    O N N 346 
PRO   CB   C N N 347 
PRO   CG   C N N 348 
PRO   CD   C N N 349 
PRO   OXT  O N N 350 
PRO   H    H N N 351 
PRO   HA   H N N 352 
PRO   HB2  H N N 353 
PRO   HB3  H N N 354 
PRO   HG2  H N N 355 
PRO   HG3  H N N 356 
PRO   HD2  H N N 357 
PRO   HD3  H N N 358 
PRO   HXT  H N N 359 
SER   N    N N N 360 
SER   CA   C N S 361 
SER   C    C N N 362 
SER   O    O N N 363 
SER   CB   C N N 364 
SER   OG   O N N 365 
SER   OXT  O N N 366 
SER   H    H N N 367 
SER   H2   H N N 368 
SER   HA   H N N 369 
SER   HB2  H N N 370 
SER   HB3  H N N 371 
SER   HG   H N N 372 
SER   HXT  H N N 373 
THR   N    N N N 374 
THR   CA   C N S 375 
THR   C    C N N 376 
THR   O    O N N 377 
THR   CB   C N R 378 
THR   OG1  O N N 379 
THR   CG2  C N N 380 
THR   OXT  O N N 381 
THR   H    H N N 382 
THR   H2   H N N 383 
THR   HA   H N N 384 
THR   HB   H N N 385 
THR   HG1  H N N 386 
THR   HG21 H N N 387 
THR   HG22 H N N 388 
THR   HG23 H N N 389 
THR   HXT  H N N 390 
TRP   N    N N N 391 
TRP   CA   C N S 392 
TRP   C    C N N 393 
TRP   O    O N N 394 
TRP   CB   C N N 395 
TRP   CG   C Y N 396 
TRP   CD1  C Y N 397 
TRP   CD2  C Y N 398 
TRP   NE1  N Y N 399 
TRP   CE2  C Y N 400 
TRP   CE3  C Y N 401 
TRP   CZ2  C Y N 402 
TRP   CZ3  C Y N 403 
TRP   CH2  C Y N 404 
TRP   OXT  O N N 405 
TRP   H    H N N 406 
TRP   H2   H N N 407 
TRP   HA   H N N 408 
TRP   HB2  H N N 409 
TRP   HB3  H N N 410 
TRP   HD1  H N N 411 
TRP   HE1  H N N 412 
TRP   HE3  H N N 413 
TRP   HZ2  H N N 414 
TRP   HZ3  H N N 415 
TRP   HH2  H N N 416 
TRP   HXT  H N N 417 
TYR   N    N N N 418 
TYR   CA   C N S 419 
TYR   C    C N N 420 
TYR   O    O N N 421 
TYR   CB   C N N 422 
TYR   CG   C Y N 423 
TYR   CD1  C Y N 424 
TYR   CD2  C Y N 425 
TYR   CE1  C Y N 426 
TYR   CE2  C Y N 427 
TYR   CZ   C Y N 428 
TYR   OH   O N N 429 
TYR   OXT  O N N 430 
TYR   H    H N N 431 
TYR   H2   H N N 432 
TYR   HA   H N N 433 
TYR   HB2  H N N 434 
TYR   HB3  H N N 435 
TYR   HD1  H N N 436 
TYR   HD2  H N N 437 
TYR   HE1  H N N 438 
TYR   HE2  H N N 439 
TYR   HH   H N N 440 
TYR   HXT  H N N 441 
VAL   N    N N N 442 
VAL   CA   C N S 443 
VAL   C    C N N 444 
VAL   O    O N N 445 
VAL   CB   C N N 446 
VAL   CG1  C N N 447 
VAL   CG2  C N N 448 
VAL   OXT  O N N 449 
VAL   H    H N N 450 
VAL   H2   H N N 451 
VAL   HA   H N N 452 
VAL   HB   H N N 453 
VAL   HG11 H N N 454 
VAL   HG12 H N N 455 
VAL   HG13 H N N 456 
VAL   HG21 H N N 457 
VAL   HG22 H N N 458 
VAL   HG23 H N N 459 
VAL   HXT  H N N 460 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1ASG C1  C2   doub Y N 1   
A1ASG C1  C6   sing Y N 2   
A1ASG C1  C7   sing Y N 3   
A1ASG C2  C3   sing Y N 4   
A1ASG C2  C9   sing Y N 5   
A1ASG C3  C4   doub Y N 6   
A1ASG C4  C5   sing Y N 7   
A1ASG C5  C6   doub Y N 8   
A1ASG C7  C8   doub Y N 9   
A1ASG C7  C10  sing N N 10  
A1ASG C8  N1   sing Y N 11  
A1ASG N1  C9   doub Y N 12  
A1ASG C10 N2   sing N N 13  
A1ASG C10 C11  sing N N 14  
A1ASG N2  C12  sing N N 15  
A1ASG C11 N3   doub N N 16  
A1ASG C12 C13  sing N N 17  
A1ASG C12 O1   doub N N 18  
A1ASG C13 C14  sing N N 19  
A1ASG C13 N4   sing N N 20  
A1ASG C14 C15  sing N N 21  
A1ASG C14 C17  sing N N 22  
A1ASG C15 C16  sing N N 23  
A1ASG C15 C17  sing N N 24  
A1ASG C16 N4   sing N N 25  
A1ASG N4  C20  sing N N 26  
A1ASG C17 C18  sing N N 27  
A1ASG C17 C19  sing N N 28  
A1ASG C20 O2   doub N N 29  
A1ASG C20 C21  sing N N 30  
A1ASG C21 N5   sing N N 31  
A1ASG C21 C22  sing N N 32  
A1ASG N5  C26  sing N N 33  
A1ASG C22 C23  sing N N 34  
A1ASG C22 C24  sing N N 35  
A1ASG C22 C25  sing N N 36  
A1ASG C26 O3   doub N N 37  
A1ASG C26 C27  sing N N 38  
A1ASG C27 F1   sing N N 39  
A1ASG C27 F2   sing N N 40  
A1ASG C27 F3   sing N N 41  
A1ASG N3  H10  sing N N 42  
A1ASG C4  H2   sing N N 43  
A1ASG C5  H3   sing N N 44  
A1ASG C6  H4   sing N N 45  
A1ASG C8  H5   sing N N 46  
A1ASG C10 H7   sing N N 47  
A1ASG C13 H11  sing N N 48  
A1ASG C15 H13  sing N N 49  
A1ASG C21 H22  sing N N 50  
A1ASG C24 H28  sing N N 51  
A1ASG C24 H29  sing N N 52  
A1ASG C24 H27  sing N N 53  
A1ASG C11 H9   sing N N 54  
A1ASG C14 H12  sing N N 55  
A1ASG C16 H14  sing N N 56  
A1ASG C16 H15  sing N N 57  
A1ASG C18 H17  sing N N 58  
A1ASG C18 H18  sing N N 59  
A1ASG C18 H16  sing N N 60  
A1ASG C19 H21  sing N N 61  
A1ASG C19 H19  sing N N 62  
A1ASG C19 H20  sing N N 63  
A1ASG C23 H25  sing N N 64  
A1ASG C23 H24  sing N N 65  
A1ASG C23 H26  sing N N 66  
A1ASG C25 H31  sing N N 67  
A1ASG C25 H30  sing N N 68  
A1ASG C25 H32  sing N N 69  
A1ASG C3  H1   sing N N 70  
A1ASG C9  H6   sing N N 71  
A1ASG N2  H8   sing N N 72  
A1ASG N5  H23  sing N N 73  
ALA   N   CA   sing N N 74  
ALA   N   H    sing N N 75  
ALA   N   H2   sing N N 76  
ALA   CA  C    sing N N 77  
ALA   CA  CB   sing N N 78  
ALA   CA  HA   sing N N 79  
ALA   C   O    doub N N 80  
ALA   C   OXT  sing N N 81  
ALA   CB  HB1  sing N N 82  
ALA   CB  HB2  sing N N 83  
ALA   CB  HB3  sing N N 84  
ALA   OXT HXT  sing N N 85  
ARG   N   CA   sing N N 86  
ARG   N   H    sing N N 87  
ARG   N   H2   sing N N 88  
ARG   CA  C    sing N N 89  
ARG   CA  CB   sing N N 90  
ARG   CA  HA   sing N N 91  
ARG   C   O    doub N N 92  
ARG   C   OXT  sing N N 93  
ARG   CB  CG   sing N N 94  
ARG   CB  HB2  sing N N 95  
ARG   CB  HB3  sing N N 96  
ARG   CG  CD   sing N N 97  
ARG   CG  HG2  sing N N 98  
ARG   CG  HG3  sing N N 99  
ARG   CD  NE   sing N N 100 
ARG   CD  HD2  sing N N 101 
ARG   CD  HD3  sing N N 102 
ARG   NE  CZ   sing N N 103 
ARG   NE  HE   sing N N 104 
ARG   CZ  NH1  sing N N 105 
ARG   CZ  NH2  doub N N 106 
ARG   NH1 HH11 sing N N 107 
ARG   NH1 HH12 sing N N 108 
ARG   NH2 HH21 sing N N 109 
ARG   NH2 HH22 sing N N 110 
ARG   OXT HXT  sing N N 111 
ASN   N   CA   sing N N 112 
ASN   N   H    sing N N 113 
ASN   N   H2   sing N N 114 
ASN   CA  C    sing N N 115 
ASN   CA  CB   sing N N 116 
ASN   CA  HA   sing N N 117 
ASN   C   O    doub N N 118 
ASN   C   OXT  sing N N 119 
ASN   CB  CG   sing N N 120 
ASN   CB  HB2  sing N N 121 
ASN   CB  HB3  sing N N 122 
ASN   CG  OD1  doub N N 123 
ASN   CG  ND2  sing N N 124 
ASN   ND2 HD21 sing N N 125 
ASN   ND2 HD22 sing N N 126 
ASN   OXT HXT  sing N N 127 
ASP   N   CA   sing N N 128 
ASP   N   H    sing N N 129 
ASP   N   H2   sing N N 130 
ASP   CA  C    sing N N 131 
ASP   CA  CB   sing N N 132 
ASP   CA  HA   sing N N 133 
ASP   C   O    doub N N 134 
ASP   C   OXT  sing N N 135 
ASP   CB  CG   sing N N 136 
ASP   CB  HB2  sing N N 137 
ASP   CB  HB3  sing N N 138 
ASP   CG  OD1  doub N N 139 
ASP   CG  OD2  sing N N 140 
ASP   OD2 HD2  sing N N 141 
ASP   OXT HXT  sing N N 142 
CYS   N   CA   sing N N 143 
CYS   N   H    sing N N 144 
CYS   N   H2   sing N N 145 
CYS   CA  C    sing N N 146 
CYS   CA  CB   sing N N 147 
CYS   CA  HA   sing N N 148 
CYS   C   O    doub N N 149 
CYS   C   OXT  sing N N 150 
CYS   CB  SG   sing N N 151 
CYS   CB  HB2  sing N N 152 
CYS   CB  HB3  sing N N 153 
CYS   SG  HG   sing N N 154 
CYS   OXT HXT  sing N N 155 
GLN   N   CA   sing N N 156 
GLN   N   H    sing N N 157 
GLN   N   H2   sing N N 158 
GLN   CA  C    sing N N 159 
GLN   CA  CB   sing N N 160 
GLN   CA  HA   sing N N 161 
GLN   C   O    doub N N 162 
GLN   C   OXT  sing N N 163 
GLN   CB  CG   sing N N 164 
GLN   CB  HB2  sing N N 165 
GLN   CB  HB3  sing N N 166 
GLN   CG  CD   sing N N 167 
GLN   CG  HG2  sing N N 168 
GLN   CG  HG3  sing N N 169 
GLN   CD  OE1  doub N N 170 
GLN   CD  NE2  sing N N 171 
GLN   NE2 HE21 sing N N 172 
GLN   NE2 HE22 sing N N 173 
GLN   OXT HXT  sing N N 174 
GLU   N   CA   sing N N 175 
GLU   N   H    sing N N 176 
GLU   N   H2   sing N N 177 
GLU   CA  C    sing N N 178 
GLU   CA  CB   sing N N 179 
GLU   CA  HA   sing N N 180 
GLU   C   O    doub N N 181 
GLU   C   OXT  sing N N 182 
GLU   CB  CG   sing N N 183 
GLU   CB  HB2  sing N N 184 
GLU   CB  HB3  sing N N 185 
GLU   CG  CD   sing N N 186 
GLU   CG  HG2  sing N N 187 
GLU   CG  HG3  sing N N 188 
GLU   CD  OE1  doub N N 189 
GLU   CD  OE2  sing N N 190 
GLU   OE2 HE2  sing N N 191 
GLU   OXT HXT  sing N N 192 
GLY   N   CA   sing N N 193 
GLY   N   H    sing N N 194 
GLY   N   H2   sing N N 195 
GLY   CA  C    sing N N 196 
GLY   CA  HA2  sing N N 197 
GLY   CA  HA3  sing N N 198 
GLY   C   O    doub N N 199 
GLY   C   OXT  sing N N 200 
GLY   OXT HXT  sing N N 201 
HIS   N   CA   sing N N 202 
HIS   N   H    sing N N 203 
HIS   N   H2   sing N N 204 
HIS   CA  C    sing N N 205 
HIS   CA  CB   sing N N 206 
HIS   CA  HA   sing N N 207 
HIS   C   O    doub N N 208 
HIS   C   OXT  sing N N 209 
HIS   CB  CG   sing N N 210 
HIS   CB  HB2  sing N N 211 
HIS   CB  HB3  sing N N 212 
HIS   CG  ND1  sing Y N 213 
HIS   CG  CD2  doub Y N 214 
HIS   ND1 CE1  doub Y N 215 
HIS   ND1 HD1  sing N N 216 
HIS   CD2 NE2  sing Y N 217 
HIS   CD2 HD2  sing N N 218 
HIS   CE1 NE2  sing Y N 219 
HIS   CE1 HE1  sing N N 220 
HIS   NE2 HE2  sing N N 221 
HIS   OXT HXT  sing N N 222 
HOH   O   H1   sing N N 223 
HOH   O   H2   sing N N 224 
ILE   N   CA   sing N N 225 
ILE   N   H    sing N N 226 
ILE   N   H2   sing N N 227 
ILE   CA  C    sing N N 228 
ILE   CA  CB   sing N N 229 
ILE   CA  HA   sing N N 230 
ILE   C   O    doub N N 231 
ILE   C   OXT  sing N N 232 
ILE   CB  CG1  sing N N 233 
ILE   CB  CG2  sing N N 234 
ILE   CB  HB   sing N N 235 
ILE   CG1 CD1  sing N N 236 
ILE   CG1 HG12 sing N N 237 
ILE   CG1 HG13 sing N N 238 
ILE   CG2 HG21 sing N N 239 
ILE   CG2 HG22 sing N N 240 
ILE   CG2 HG23 sing N N 241 
ILE   CD1 HD11 sing N N 242 
ILE   CD1 HD12 sing N N 243 
ILE   CD1 HD13 sing N N 244 
ILE   OXT HXT  sing N N 245 
LEU   N   CA   sing N N 246 
LEU   N   H    sing N N 247 
LEU   N   H2   sing N N 248 
LEU   CA  C    sing N N 249 
LEU   CA  CB   sing N N 250 
LEU   CA  HA   sing N N 251 
LEU   C   O    doub N N 252 
LEU   C   OXT  sing N N 253 
LEU   CB  CG   sing N N 254 
LEU   CB  HB2  sing N N 255 
LEU   CB  HB3  sing N N 256 
LEU   CG  CD1  sing N N 257 
LEU   CG  CD2  sing N N 258 
LEU   CG  HG   sing N N 259 
LEU   CD1 HD11 sing N N 260 
LEU   CD1 HD12 sing N N 261 
LEU   CD1 HD13 sing N N 262 
LEU   CD2 HD21 sing N N 263 
LEU   CD2 HD22 sing N N 264 
LEU   CD2 HD23 sing N N 265 
LEU   OXT HXT  sing N N 266 
LYS   N   CA   sing N N 267 
LYS   N   H    sing N N 268 
LYS   N   H2   sing N N 269 
LYS   CA  C    sing N N 270 
LYS   CA  CB   sing N N 271 
LYS   CA  HA   sing N N 272 
LYS   C   O    doub N N 273 
LYS   C   OXT  sing N N 274 
LYS   CB  CG   sing N N 275 
LYS   CB  HB2  sing N N 276 
LYS   CB  HB3  sing N N 277 
LYS   CG  CD   sing N N 278 
LYS   CG  HG2  sing N N 279 
LYS   CG  HG3  sing N N 280 
LYS   CD  CE   sing N N 281 
LYS   CD  HD2  sing N N 282 
LYS   CD  HD3  sing N N 283 
LYS   CE  NZ   sing N N 284 
LYS   CE  HE2  sing N N 285 
LYS   CE  HE3  sing N N 286 
LYS   NZ  HZ1  sing N N 287 
LYS   NZ  HZ2  sing N N 288 
LYS   NZ  HZ3  sing N N 289 
LYS   OXT HXT  sing N N 290 
MET   N   CA   sing N N 291 
MET   N   H    sing N N 292 
MET   N   H2   sing N N 293 
MET   CA  C    sing N N 294 
MET   CA  CB   sing N N 295 
MET   CA  HA   sing N N 296 
MET   C   O    doub N N 297 
MET   C   OXT  sing N N 298 
MET   CB  CG   sing N N 299 
MET   CB  HB2  sing N N 300 
MET   CB  HB3  sing N N 301 
MET   CG  SD   sing N N 302 
MET   CG  HG2  sing N N 303 
MET   CG  HG3  sing N N 304 
MET   SD  CE   sing N N 305 
MET   CE  HE1  sing N N 306 
MET   CE  HE2  sing N N 307 
MET   CE  HE3  sing N N 308 
MET   OXT HXT  sing N N 309 
PHE   N   CA   sing N N 310 
PHE   N   H    sing N N 311 
PHE   N   H2   sing N N 312 
PHE   CA  C    sing N N 313 
PHE   CA  CB   sing N N 314 
PHE   CA  HA   sing N N 315 
PHE   C   O    doub N N 316 
PHE   C   OXT  sing N N 317 
PHE   CB  CG   sing N N 318 
PHE   CB  HB2  sing N N 319 
PHE   CB  HB3  sing N N 320 
PHE   CG  CD1  doub Y N 321 
PHE   CG  CD2  sing Y N 322 
PHE   CD1 CE1  sing Y N 323 
PHE   CD1 HD1  sing N N 324 
PHE   CD2 CE2  doub Y N 325 
PHE   CD2 HD2  sing N N 326 
PHE   CE1 CZ   doub Y N 327 
PHE   CE1 HE1  sing N N 328 
PHE   CE2 CZ   sing Y N 329 
PHE   CE2 HE2  sing N N 330 
PHE   CZ  HZ   sing N N 331 
PHE   OXT HXT  sing N N 332 
PRO   N   CA   sing N N 333 
PRO   N   CD   sing N N 334 
PRO   N   H    sing N N 335 
PRO   CA  C    sing N N 336 
PRO   CA  CB   sing N N 337 
PRO   CA  HA   sing N N 338 
PRO   C   O    doub N N 339 
PRO   C   OXT  sing N N 340 
PRO   CB  CG   sing N N 341 
PRO   CB  HB2  sing N N 342 
PRO   CB  HB3  sing N N 343 
PRO   CG  CD   sing N N 344 
PRO   CG  HG2  sing N N 345 
PRO   CG  HG3  sing N N 346 
PRO   CD  HD2  sing N N 347 
PRO   CD  HD3  sing N N 348 
PRO   OXT HXT  sing N N 349 
SER   N   CA   sing N N 350 
SER   N   H    sing N N 351 
SER   N   H2   sing N N 352 
SER   CA  C    sing N N 353 
SER   CA  CB   sing N N 354 
SER   CA  HA   sing N N 355 
SER   C   O    doub N N 356 
SER   C   OXT  sing N N 357 
SER   CB  OG   sing N N 358 
SER   CB  HB2  sing N N 359 
SER   CB  HB3  sing N N 360 
SER   OG  HG   sing N N 361 
SER   OXT HXT  sing N N 362 
THR   N   CA   sing N N 363 
THR   N   H    sing N N 364 
THR   N   H2   sing N N 365 
THR   CA  C    sing N N 366 
THR   CA  CB   sing N N 367 
THR   CA  HA   sing N N 368 
THR   C   O    doub N N 369 
THR   C   OXT  sing N N 370 
THR   CB  OG1  sing N N 371 
THR   CB  CG2  sing N N 372 
THR   CB  HB   sing N N 373 
THR   OG1 HG1  sing N N 374 
THR   CG2 HG21 sing N N 375 
THR   CG2 HG22 sing N N 376 
THR   CG2 HG23 sing N N 377 
THR   OXT HXT  sing N N 378 
TRP   N   CA   sing N N 379 
TRP   N   H    sing N N 380 
TRP   N   H2   sing N N 381 
TRP   CA  C    sing N N 382 
TRP   CA  CB   sing N N 383 
TRP   CA  HA   sing N N 384 
TRP   C   O    doub N N 385 
TRP   C   OXT  sing N N 386 
TRP   CB  CG   sing N N 387 
TRP   CB  HB2  sing N N 388 
TRP   CB  HB3  sing N N 389 
TRP   CG  CD1  doub Y N 390 
TRP   CG  CD2  sing Y N 391 
TRP   CD1 NE1  sing Y N 392 
TRP   CD1 HD1  sing N N 393 
TRP   CD2 CE2  doub Y N 394 
TRP   CD2 CE3  sing Y N 395 
TRP   NE1 CE2  sing Y N 396 
TRP   NE1 HE1  sing N N 397 
TRP   CE2 CZ2  sing Y N 398 
TRP   CE3 CZ3  doub Y N 399 
TRP   CE3 HE3  sing N N 400 
TRP   CZ2 CH2  doub Y N 401 
TRP   CZ2 HZ2  sing N N 402 
TRP   CZ3 CH2  sing Y N 403 
TRP   CZ3 HZ3  sing N N 404 
TRP   CH2 HH2  sing N N 405 
TRP   OXT HXT  sing N N 406 
TYR   N   CA   sing N N 407 
TYR   N   H    sing N N 408 
TYR   N   H2   sing N N 409 
TYR   CA  C    sing N N 410 
TYR   CA  CB   sing N N 411 
TYR   CA  HA   sing N N 412 
TYR   C   O    doub N N 413 
TYR   C   OXT  sing N N 414 
TYR   CB  CG   sing N N 415 
TYR   CB  HB2  sing N N 416 
TYR   CB  HB3  sing N N 417 
TYR   CG  CD1  doub Y N 418 
TYR   CG  CD2  sing Y N 419 
TYR   CD1 CE1  sing Y N 420 
TYR   CD1 HD1  sing N N 421 
TYR   CD2 CE2  doub Y N 422 
TYR   CD2 HD2  sing N N 423 
TYR   CE1 CZ   doub Y N 424 
TYR   CE1 HE1  sing N N 425 
TYR   CE2 CZ   sing Y N 426 
TYR   CE2 HE2  sing N N 427 
TYR   CZ  OH   sing N N 428 
TYR   OH  HH   sing N N 429 
TYR   OXT HXT  sing N N 430 
VAL   N   CA   sing N N 431 
VAL   N   H    sing N N 432 
VAL   N   H2   sing N N 433 
VAL   CA  C    sing N N 434 
VAL   CA  CB   sing N N 435 
VAL   CA  HA   sing N N 436 
VAL   C   O    doub N N 437 
VAL   C   OXT  sing N N 438 
VAL   CB  CG1  sing N N 439 
VAL   CB  CG2  sing N N 440 
VAL   CB  HB   sing N N 441 
VAL   CG1 HG11 sing N N 442 
VAL   CG1 HG12 sing N N 443 
VAL   CG1 HG13 sing N N 444 
VAL   CG2 HG21 sing N N 445 
VAL   CG2 HG22 sing N N 446 
VAL   CG2 HG23 sing N N 447 
VAL   OXT HXT  sing N N 448 
# 
_pdbx_audit_support.funding_organization   'Welch Foundation' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7JPY 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'I 1 2 1' 
_space_group.name_Hall        'C 2y (x,y,-x+z)' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9BTK 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.019380 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.002464 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.012444 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.011214 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
F ? ? 4.90428 4.07044 ? ? 12.99538 1.63651  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . SER   A 1 1   ? -33.10123 -18.69464 15.11489  1.000 15.92424 ? 1   SER   A N   1 
ATOM   2    C CA  . SER   A 1 1   ? -32.33993 -19.80859 14.57336  1.000 18.78398 ? 1   SER   A CA  1 
ATOM   3    C C   . SER   A 1 1   ? -32.36983 -19.88169 13.04179  1.000 17.54557 ? 1   SER   A C   1 
ATOM   4    O O   . SER   A 1 1   ? -32.83445 -18.94251 12.38482  1.000 14.75043 ? 1   SER   A O   1 
ATOM   5    C CB  . SER   A 1 1   ? -32.82425 -21.09598 15.21139  1.000 27.26348 ? 1   SER   A CB  1 
ATOM   6    O OG  . SER   A 1 1   ? -34.11923 -21.40729 14.78518  1.000 29.76530 ? 1   SER   A OG  1 
ATOM   7    N N   . GLY   A 1 2   ? -31.84922 -20.97483 12.48838  1.000 14.98532 ? 2   GLY   A N   1 
ATOM   8    C CA  . GLY   A 1 2   ? -31.57103 -21.12803 11.07450  1.000 15.17135 ? 2   GLY   A CA  1 
ATOM   9    C C   . GLY   A 1 2   ? -30.10692 -20.82249 10.78848  1.000 19.47003 ? 2   GLY   A C   1 
ATOM   10   O O   . GLY   A 1 2   ? -29.40036 -20.21334 11.59047  1.000 17.78289 ? 2   GLY   A O   1 
ATOM   11   N N   . PHE   A 1 3   ? -29.63170 -21.27458 9.63780   1.000 13.74000 ? 3   PHE   A N   1 
ATOM   12   C CA  . PHE   A 1 3   ? -28.21597 -21.09905 9.30499   1.000 15.63875 ? 3   PHE   A CA  1 
ATOM   13   C C   . PHE   A 1 3   ? -28.12834 -20.99546 7.79906   1.000 19.94626 ? 3   PHE   A C   1 
ATOM   14   O O   . PHE   A 1 3   ? -28.55513 -21.90674 7.08285   1.000 18.69980 ? 3   PHE   A O   1 
ATOM   15   C CB  . PHE   A 1 3   ? -27.32269 -22.24518 9.83159   1.000 14.07582 ? 3   PHE   A CB  1 
ATOM   16   C CG  . PHE   A 1 3   ? -25.86896 -21.83316 9.99290   1.000 13.59951 ? 3   PHE   A CG  1 
ATOM   17   C CD1 . PHE   A 1 3   ? -25.48616 -21.00109 11.04356  1.000 16.41138 ? 3   PHE   A CD1 1 
ATOM   18   C CD2 . PHE   A 1 3   ? -24.91509 -22.20246 9.04702   1.000 14.93566 ? 3   PHE   A CD2 1 
ATOM   19   C CE1 . PHE   A 1 3   ? -24.15174 -20.57335 11.17526  1.000 18.39100 ? 3   PHE   A CE1 1 
ATOM   20   C CE2 . PHE   A 1 3   ? -23.59100 -21.80309 9.19279   1.000 17.62411 ? 3   PHE   A CE2 1 
ATOM   21   C CZ  . PHE   A 1 3   ? -23.22258 -20.98405 10.25968  1.000 14.24629 ? 3   PHE   A CZ  1 
ATOM   22   N N   . ARG   A 1 4   ? -27.64077 -19.86675 7.32471   1.000 16.87541 ? 4   ARG   A N   1 
ATOM   23   C CA  . ARG   A 1 4   ? -27.65151 -19.57207 5.90985   1.000 14.37566 ? 4   ARG   A CA  1 
ATOM   24   C C   . ARG   A 1 4   ? -26.27662 -19.08047 5.51540   1.000 16.74228 ? 4   ARG   A C   1 
ATOM   25   O O   . ARG   A 1 4   ? -25.57701 -18.46514 6.32026   1.000 16.49721 ? 4   ARG   A O   1 
ATOM   26   C CB  . ARG   A 1 4   ? -28.67258 -18.48186 5.57848   1.000 14.06774 ? 4   ARG   A CB  1 
ATOM   27   C CG  . ARG   A 1 4   ? -30.08404 -18.98830 5.52817   1.000 15.54125 ? 4   ARG   A CG  1 
ATOM   28   C CD  . ARG   A 1 4   ? -30.31943 -19.56238 4.11990   1.000 19.27584 ? 4   ARG   A CD  1 
ATOM   29   N NE  . ARG   A 1 4   ? -31.74209 -19.82833 3.86625   1.000 20.13172 ? 4   ARG   A NE  1 
ATOM   30   C CZ  . ARG   A 1 4   ? -32.19748 -20.44003 2.76854   1.000 20.82958 ? 4   ARG   A CZ  1 
ATOM   31   N NH1 . ARG   A 1 4   ? -31.33074 -20.81208 1.84603   1.000 19.68947 ? 4   ARG   A NH1 1 
ATOM   32   N NH2 . ARG   A 1 4   ? -33.49972 -20.68355 2.58659   1.000 16.53260 ? 4   ARG   A NH2 1 
ATOM   33   N N   . LYS   A 1 5   ? -25.91565 -19.30890 4.28458   1.000 17.67597 ? 5   LYS   A N   1 
ATOM   34   C CA  . LYS   A 1 5   ? -24.67434 -18.69525 3.88521   1.000 21.12072 ? 5   LYS   A CA  1 
ATOM   35   C C   . LYS   A 1 5   ? -24.94296 -17.20766 3.62755   1.000 13.72188 ? 5   LYS   A C   1 
ATOM   36   O O   . LYS   A 1 5   ? -25.86521 -16.81927 2.92804   1.000 20.01682 ? 5   LYS   A O   1 
ATOM   37   C CB  . LYS   A 1 5   ? -23.87228 -19.61179 2.90345   1.000 30.35713 ? 5   LYS   A CB  1 
ATOM   38   C CG  . LYS   A 1 5   ? -22.37261 -19.09806 2.08964   1.000 25.68322 ? 5   LYS   A CG  1 
ATOM   39   C CD  . LYS   A 1 5   ? -22.57877 -20.46051 1.46034   1.000 27.88083 ? 5   LYS   A CD  1 
ATOM   40   C CE  . LYS   A 1 5   ? -22.20478 -22.08972 2.05527   1.000 32.67966 ? 5   LYS   A CE  1 
ATOM   41   N NZ  . LYS   A 1 5   ? -20.40330 -22.06991 1.81373   1.000 37.89686 ? 5   LYS   A NZ  1 
ATOM   42   N N   . MET   A 1 6   ? -24.38087 -16.42538 4.54946   1.000 10.80294 ? 6   MET   A N   1 
ATOM   43   C CA  . MET   A 1 6   ? -24.79732 -15.05135 4.75910   1.000 9.18125  ? 6   MET   A CA  1 
ATOM   44   C C   . MET   A 1 6   ? -23.66202 -14.13605 4.34892   1.000 13.91482 ? 6   MET   A C   1 
ATOM   45   O O   . MET   A 1 6   ? -22.51985 -14.34082 4.78062   1.000 14.96334 ? 6   MET   A O   1 
ATOM   46   C CB  . MET   A 1 6   ? -25.16463 -14.83198 6.23000   1.000 11.68795 ? 6   MET   A CB  1 
ATOM   47   C CG  . MET   A 1 6   ? -25.73170 -13.50705 6.51178   1.000 17.26204 ? 6   MET   A CG  1 
ATOM   48   S SD  . MET   A 1 6   ? -26.10416 -13.39160 8.27749   1.000 25.87854 ? 6   MET   A SD  1 
ATOM   49   C CE  . MET   A 1 6   ? -27.66022 -14.25173 8.32448   1.000 17.01355 ? 6   MET   A CE  1 
ATOM   50   N N   . ALA   A 1 7   ? -23.95406 -13.14119 3.52211   1.000 11.47880 ? 7   ALA   A N   1 
ATOM   51   C CA  . ALA   A 1 7   ? -22.91796 -12.17642 3.16922   1.000 9.07234  ? 7   ALA   A CA  1 
ATOM   52   C C   . ALA   A 1 7   ? -23.09500 -10.90994 3.97613   1.000 12.85991 ? 7   ALA   A C   1 
ATOM   53   O O   . ALA   A 1 7   ? -24.14868 -10.68895 4.58100   1.000 8.78275  ? 7   ALA   A O   1 
ATOM   54   C CB  . ALA   A 1 7   ? -22.94883 -11.83741 1.68550   1.000 11.66662 ? 7   ALA   A CB  1 
ATOM   55   N N   . PHE   A 1 8   ? -22.05009 -10.07419 3.98872   1.000 8.75610  ? 8   PHE   A N   1 
ATOM   56   C CA  . PHE   A 1 8   ? -22.19678 -8.75582  4.60208   1.000 8.41900  ? 8   PHE   A CA  1 
ATOM   57   C C   . PHE   A 1 8   ? -23.07534 -7.85744  3.73478   1.000 11.90947 ? 8   PHE   A C   1 
ATOM   58   O O   . PHE   A 1 8   ? -23.10308 -8.00329  2.50958   1.000 9.36548  ? 8   PHE   A O   1 
ATOM   59   C CB  . PHE   A 1 8   ? -20.84168 -8.08032  4.78449   1.000 10.54582 ? 8   PHE   A CB  1 
ATOM   60   C CG  . PHE   A 1 8   ? -20.01643 -8.71199  5.84172   1.000 13.76996 ? 8   PHE   A CG  1 
ATOM   61   C CD1 . PHE   A 1 8   ? -20.22528 -8.38975  7.17286   1.000 18.02490 ? 8   PHE   A CD1 1 
ATOM   62   C CD2 . PHE   A 1 8   ? -19.05113 -9.64217  5.52271   1.000 18.17837 ? 8   PHE   A CD2 1 
ATOM   63   C CE1 . PHE   A 1 8   ? -19.46137 -8.96801  8.17284   1.000 26.33520 ? 8   PHE   A CE1 1 
ATOM   64   C CE2 . PHE   A 1 8   ? -18.26989 -10.23519 6.53948   1.000 18.46862 ? 8   PHE   A CE2 1 
ATOM   65   C CZ  . PHE   A 1 8   ? -18.49625 -9.89990  7.86890   1.000 20.77344 ? 8   PHE   A CZ  1 
ATOM   66   N N   . PRO   A 1 9   ? -23.78066 -6.89912  4.34615   1.000 8.51621  ? 9   PRO   A N   1 
ATOM   67   C CA  . PRO   A 1 9   ? -24.53634 -5.92565  3.55577   1.000 10.32881 ? 9   PRO   A CA  1 
ATOM   68   C C   . PRO   A 1 9   ? -23.56078 -5.23053  2.62624   1.000 12.20425 ? 9   PRO   A C   1 
ATOM   69   O O   . PRO   A 1 9   ? -22.42724 -4.94315  3.01569   1.000 11.69520 ? 9   PRO   A O   1 
ATOM   70   C CB  . PRO   A 1 9   ? -25.08563 -4.95660  4.60846   1.000 9.55125  ? 9   PRO   A CB  1 
ATOM   71   C CG  . PRO   A 1 9   ? -25.04952 -5.66914  5.88514   1.000 14.11574 ? 9   PRO   A CG  1 
ATOM   72   C CD  . PRO   A 1 9   ? -23.86735 -6.62820  5.79269   1.000 10.04428 ? 9   PRO   A CD  1 
ATOM   73   N N   . SER   A 1 10  ? -23.97879 -5.00625  1.38191   1.000 10.26202 ? 10  SER   A N   1 
ATOM   74   C CA  . SER   A 1 10  ? -23.02699 -4.62357  0.33836   1.000 8.14135  ? 10  SER   A CA  1 
ATOM   75   C C   . SER   A 1 10  ? -23.02604 -3.13619  0.05917   1.000 10.70384 ? 10  SER   A C   1 
ATOM   76   O O   . SER   A 1 10  ? -22.20322 -2.66679  -0.74701  1.000 11.79530 ? 10  SER   A O   1 
ATOM   77   C CB  . SER   A 1 10  ? -23.30679 -5.36393  -0.97458  1.000 9.09204  ? 10  SER   A CB  1 
ATOM   78   O OG  . SER   A 1 10  ? -24.62568 -5.14759  -1.48577  1.000 10.14588 ? 10  SER   A OG  1 
ATOM   79   N N   . GLY   A 1 11  ? -23.92064 -2.38872  0.68955   1.000 9.36542  ? 11  GLY   A N   1 
ATOM   80   C CA  . GLY   A 1 11  ? -24.09405 -0.98831  0.31863   1.000 11.00005 ? 11  GLY   A CA  1 
ATOM   81   C C   . GLY   A 1 11  ? -22.80152 -0.19194  0.26350   1.000 12.11521 ? 11  GLY   A C   1 
ATOM   82   O O   . GLY   A 1 11  ? -22.58604 0.58903   -0.67623  1.000 14.54935 ? 11  GLY   A O   1 
ATOM   83   N N   . LYS   A 1 12  ? -21.96013 -0.31669  1.31269   1.000 11.54544 ? 12  LYS   A N   1 
ATOM   84   C CA  . LYS   A 1 12  ? -20.74358 0.48643   1.42379   1.000 12.87137 ? 12  LYS   A CA  1 
ATOM   85   C C   . LYS   A 1 12  ? -19.81487 0.23076   0.26783   1.000 14.26610 ? 12  LYS   A C   1 
ATOM   86   O O   . LYS   A 1 12  ? -19.09715 1.14397   -0.16399  1.000 15.89828 ? 12  LYS   A O   1 
ATOM   87   C CB  . LYS   A 1 12  ? -19.99201 0.22005   2.73753   1.000 16.30928 ? 12  LYS   A CB  1 
ATOM   88   C CG  . LYS   A 1 12  ? -20.68580 0.68262   3.99952   1.000 19.64524 ? 12  LYS   A CG  1 
ATOM   89   C CD  . LYS   A 1 12  ? -19.72680 0.72640   5.17748   1.000 22.27178 ? 12  LYS   A CD  1 
ATOM   90   C CE  . LYS   A 1 12  ? -20.48929 0.39848   6.44192   1.000 35.38868 ? 12  LYS   A CE  1 
ATOM   91   N NZ  . LYS   A 1 12  ? -21.64975 1.27823   6.72333   1.000 35.25691 ? 12  LYS   A NZ  1 
ATOM   92   N N   . VAL   A 1 13  ? -19.85285 -0.97817  -0.27583  1.000 11.13728 ? 13  VAL   A N   1 
ATOM   93   C CA  . VAL   A 1 13  ? -19.03347 -1.31920  -1.43683  1.000 12.82859 ? 13  VAL   A CA  1 
ATOM   94   C C   . VAL   A 1 13  ? -19.69510 -0.91273  -2.74269  1.000 12.20973 ? 13  VAL   A C   1 
ATOM   95   O O   . VAL   A 1 13  ? -19.00702 -0.53338  -3.69799  1.000 11.10187 ? 13  VAL   A O   1 
ATOM   96   C CB  . VAL   A 1 13  ? -18.72237 -2.82290  -1.41177  1.000 10.02436 ? 13  VAL   A CB  1 
ATOM   97   C CG1 . VAL   A 1 13  ? -17.86065 -3.21914  -2.62713  1.000 10.61250 ? 13  VAL   A CG1 1 
ATOM   98   C CG2 . VAL   A 1 13  ? -18.02449 -3.13674  -0.11286  1.000 10.83053 ? 13  VAL   A CG2 1 
ATOM   99   N N   . GLU   A 1 14  ? -21.03109 -1.02118  -2.83152  1.000 9.49053  ? 14  GLU   A N   1 
ATOM   100  C CA  . GLU   A 1 14  ? -21.72671 -0.59236  -4.04252  1.000 7.97089  ? 14  GLU   A CA  1 
ATOM   101  C C   . GLU   A 1 14  ? -21.36651 0.83082   -4.40729  1.000 11.77537 ? 14  GLU   A C   1 
ATOM   102  O O   . GLU   A 1 14  ? -21.22961 1.14825   -5.59360  1.000 14.34967 ? 14  GLU   A O   1 
ATOM   103  C CB  . GLU   A 1 14  ? -23.25178 -0.69292  -3.87126  1.000 12.11826 ? 14  GLU   A CB  1 
ATOM   104  C CG  . GLU   A 1 14  ? -23.72092 -2.14931  -3.66254  1.000 7.10937  ? 14  GLU   A CG  1 
ATOM   105  C CD  . GLU   A 1 14  ? -25.15033 -2.25254  -3.18558  1.000 13.79183 ? 14  GLU   A CD  1 
ATOM   106  O OE1 . GLU   A 1 14  ? -26.02963 -1.57502  -3.77849  1.000 11.66239 ? 14  GLU   A OE1 1 
ATOM   107  O OE2 . GLU   A 1 14  ? -25.37300 -2.95321  -2.16065  1.000 13.46160 ? 14  GLU   A OE2 1 
ATOM   108  N N   . GLY   A 1 15  ? -21.22675 1.70402   -3.41098  1.000 12.13541 ? 15  GLY   A N   1 
ATOM   109  C CA  . GLY   A 1 15  ? -20.91408 3.08634   -3.73423  1.000 14.88333 ? 15  GLY   A CA  1 
ATOM   110  C C   . GLY   A 1 15  ? -19.50502 3.32909   -4.24341  1.000 17.86274 ? 15  GLY   A C   1 
ATOM   111  O O   . GLY   A 1 15  ? -19.15666 4.48637   -4.50712  1.000 16.05118 ? 15  GLY   A O   1 
ATOM   112  N N   . CYS   A 1 16  ? -18.68165 2.27434   -4.35366  1.000 11.49913 ? 16  CYS   A N   1 
ATOM   113  C CA  . CYS   A 1 16  ? -17.30280 2.36925   -4.81455  1.000 11.75147 ? 16  CYS   A CA  1 
ATOM   114  C C   . CYS   A 1 16  ? -17.09675 1.79748   -6.20102  1.000 12.87871 ? 16  CYS   A C   1 
ATOM   115  O O   . CYS   A 1 16  ? -15.99526 1.93190   -6.73868  1.000 11.01039 ? 16  CYS   A O   1 
ATOM   116  C CB  . CYS   A 1 16  ? -16.34284 1.63698   -3.86379  1.000 8.00075  ? 16  CYS   A CB  1 
ATOM   117  S SG  . CYS   A 1 16  ? -16.32773 2.28283   -2.15282  1.000 13.05725 ? 16  CYS   A SG  1 
ATOM   118  N N   . MET   A 1 17  ? -18.10045 1.13991   -6.77595  1.000 10.28543 ? 17  MET   A N   1 
ATOM   119  C CA  . MET   A 1 17  ? -17.90538 0.42718   -8.02609  1.000 10.71027 ? 17  MET   A CA  1 
ATOM   120  C C   . MET   A 1 17  ? -18.07662 1.38200   -9.18179  1.000 15.30248 ? 17  MET   A C   1 
ATOM   121  O O   . MET   A 1 17  ? -19.01380 2.18837   -9.19004  1.000 14.15886 ? 17  MET   A O   1 
ATOM   122  C CB  . MET   A 1 17  ? -18.85075 -0.76932  -8.16792  1.000 10.74905 ? 17  MET   A CB  1 
ATOM   123  C CG  . MET   A 1 17  ? -18.76613 -1.68442  -6.92827  1.000 11.66220 ? 17  MET   A CG  1 
ATOM   124  S SD  . MET   A 1 17  ? -17.04461 -2.26122  -6.62988  1.000 11.56659 ? 17  MET   A SD  1 
ATOM   125  C CE  . MET   A 1 17  ? -16.56134 -2.73102  -8.22528  1.000 10.82608 ? 17  MET   A CE  1 
ATOM   126  N N   . VAL   A 1 18  ? -17.14062 1.29123   -10.13793 1.000 15.04014 ? 18  VAL   A N   1 
ATOM   127  C CA  . VAL   A 1 18  ? -17.11104 2.06902   -11.36994 1.000 14.55985 ? 18  VAL   A CA  1 
ATOM   128  C C   . VAL   A 1 18  ? -16.74413 1.13358   -12.51905 1.000 13.12264 ? 18  VAL   A C   1 
ATOM   129  O O   . VAL   A 1 18  ? -16.33485 -0.00035  -12.31339 1.000 11.95232 ? 18  VAL   A O   1 
ATOM   130  C CB  . VAL   A 1 18  ? -16.10192 3.23300   -11.29709 1.000 14.04645 ? 18  VAL   A CB  1 
ATOM   131  C CG1 . VAL   A 1 18  ? -16.41965 4.13743   -10.13548 1.000 15.49611 ? 18  VAL   A CG1 1 
ATOM   132  C CG2 . VAL   A 1 18  ? -14.68101 2.69927   -11.21230 1.000 12.60289 ? 18  VAL   A CG2 1 
ATOM   133  N N   . GLN   A 1 19  ? -16.89028 1.64449   -13.74058 1.000 14.98916 ? 19  GLN   A N   1 
ATOM   134  C CA  . GLN   A 1 19  ? -16.59066 0.95613   -14.98940 1.000 18.41136 ? 19  GLN   A CA  1 
ATOM   135  C C   . GLN   A 1 19  ? -15.30822 1.54509   -15.55054 1.000 15.67922 ? 19  GLN   A C   1 
ATOM   136  O O   . GLN   A 1 19  ? -15.17027 2.76580   -15.60681 1.000 17.55319 ? 19  GLN   A O   1 
ATOM   137  C CB  . GLN   A 1 19  ? -17.75366 1.15507   -15.97379 1.000 21.58249 ? 19  GLN   A CB  1 
ATOM   138  C CG  . GLN   A 1 19  ? -17.58630 0.57907   -17.35139 1.000 22.16135 ? 19  GLN   A CG  1 
ATOM   139  C CD  . GLN   A 1 19  ? -18.88020 0.65462   -18.16319 1.000 26.10959 ? 19  GLN   A CD  1 
ATOM   140  O OE1 . GLN   A 1 19  ? -19.19512 -0.25375  -18.93099 1.000 30.05474 ? 19  GLN   A OE1 1 
ATOM   141  N NE2 . GLN   A 1 19  ? -19.65133 1.71483   -17.95929 1.000 31.02161 ? 19  GLN   A NE2 1 
ATOM   142  N N   . VAL   A 1 20  ? -14.35575 0.69665   -15.91336 1.000 15.70901 ? 20  VAL   A N   1 
ATOM   143  C CA  . VAL   A 1 20  ? -13.10318 1.14950   -16.50040 1.000 16.82107 ? 20  VAL   A CA  1 
ATOM   144  C C   . VAL   A 1 20  ? -13.02683 0.59786   -17.90836 1.000 17.36961 ? 20  VAL   A C   1 
ATOM   145  O O   . VAL   A 1 20  ? -13.13048 -0.61218  -18.10781 1.000 16.51971 ? 20  VAL   A O   1 
ATOM   146  C CB  . VAL   A 1 20  ? -11.88397 0.70344   -15.66616 1.000 13.31627 ? 20  VAL   A CB  1 
ATOM   147  C CG1 . VAL   A 1 20  ? -10.61636 1.19665   -16.28782 1.000 16.33216 ? 20  VAL   A CG1 1 
ATOM   148  C CG2 . VAL   A 1 20  ? -11.97213 1.26459   -14.28233 1.000 13.24079 ? 20  VAL   A CG2 1 
ATOM   149  N N   . THR   A 1 21  ? -12.83020 1.47357   -18.88719 1.000 19.80531 ? 21  THR   A N   1 
ATOM   150  C CA  . THR   A 1 21  ? -12.67740 1.02514   -20.26110 1.000 18.62099 ? 21  THR   A CA  1 
ATOM   151  C C   . THR   A 1 21  ? -11.31264 1.43902   -20.79192 1.000 20.39561 ? 21  THR   A C   1 
ATOM   152  O O   . THR   A 1 21  ? -10.86670 2.57747   -20.60008 1.000 24.75706 ? 21  THR   A O   1 
ATOM   153  C CB  . THR   A 1 21  ? -13.78303 1.60713   -21.16724 1.000 23.17267 ? 21  THR   A CB  1 
ATOM   154  O OG1 . THR   A 1 21  ? -15.05712 1.11576   -20.74121 1.000 23.09019 ? 21  THR   A OG1 1 
ATOM   155  C CG2 . THR   A 1 21  ? -13.56336 1.19865   -22.62488 1.000 21.96946 ? 21  THR   A CG2 1 
ATOM   156  N N   . CYS   A 1 22  ? -10.66528 0.52460   -21.49373 1.000 22.55486 ? 22  CYS   A N   1 
ATOM   157  C CA  . CYS   A 1 22  ? -9.43120  0.86298   -22.17305 1.000 23.38953 ? 22  CYS   A CA  1 
ATOM   158  C C   . CYS   A 1 22  ? -9.43673  0.08246   -23.47673 1.000 25.50451 ? 22  CYS   A C   1 
ATOM   159  O O   . CYS   A 1 22  ? -9.54771  -1.15118  -23.46772 1.000 24.51517 ? 22  CYS   A O   1 
ATOM   160  C CB  . CYS   A 1 22  ? -8.22913  0.53388   -21.28099 1.000 24.13405 ? 22  CYS   A CB  1 
ATOM   161  S SG  . CYS   A 1 22  ? -6.64077  0.73412   -22.06673 1.000 25.38648 ? 22  CYS   A SG  1 
ATOM   162  N N   . GLY   A 1 23  ? -9.41724  0.79611   -24.59578 1.000 26.44760 ? 23  GLY   A N   1 
ATOM   163  C CA  . GLY   A 1 23  ? -9.53713  0.10192   -25.86964 1.000 23.97622 ? 23  GLY   A CA  1 
ATOM   164  C C   . GLY   A 1 23  ? -10.91840 -0.51479  -25.99846 1.000 23.02912 ? 23  GLY   A C   1 
ATOM   165  O O   . GLY   A 1 23  ? -11.94438 0.14595   -25.79477 1.000 24.65406 ? 23  GLY   A O   1 
ATOM   166  N N   . THR   A 1 24  ? -10.97732 -1.80173  -26.32737 1.000 24.70070 ? 24  THR   A N   1 
ATOM   167  C CA  . THR   A 1 24  ? -12.27240 -2.46281  -26.39364 1.000 29.40802 ? 24  THR   A CA  1 
ATOM   168  C C   . THR   A 1 24  ? -12.53533 -3.34331  -25.18054 1.000 30.90079 ? 24  THR   A C   1 
ATOM   169  O O   . THR   A 1 24  ? -13.44325 -4.18018  -25.21612 1.000 34.93671 ? 24  THR   A O   1 
ATOM   170  C CB  . THR   A 1 24  ? -12.38164 -3.29842  -27.65944 1.000 26.72088 ? 24  THR   A CB  1 
ATOM   171  O OG1 . THR   A 1 24  ? -11.28216 -4.20230  -27.69257 1.000 29.38439 ? 24  THR   A OG1 1 
ATOM   172  C CG2 . THR   A 1 24  ? -12.30634 -2.38811  -28.87816 1.000 29.26265 ? 24  THR   A CG2 1 
ATOM   173  N N   . THR   A 1 25  ? -11.76629 -3.18024  -24.11359 1.000 27.45118 ? 25  THR   A N   1 
ATOM   174  C CA  . THR   A 1 25  ? -11.95827 -3.96204  -22.89829 1.000 26.74503 ? 25  THR   A CA  1 
ATOM   175  C C   . THR   A 1 25  ? -12.66789 -3.09930  -21.86539 1.000 25.55477 ? 25  THR   A C   1 
ATOM   176  O O   . THR   A 1 25  ? -12.19911 -2.00670  -21.53706 1.000 24.62530 ? 25  THR   A O   1 
ATOM   177  C CB  . THR   A 1 25  ? -10.61411 -4.47794  -22.37938 1.000 29.20924 ? 25  THR   A CB  1 
ATOM   178  O OG1 . THR   A 1 25  ? -9.93032  -5.14048  -23.45103 1.000 34.96856 ? 25  THR   A OG1 1 
ATOM   179  C CG2 . THR   A 1 25  ? -10.79284 -5.45241  -21.19500 1.000 27.74144 ? 25  THR   A CG2 1 
ATOM   180  N N   . THR   A 1 26  ? -13.80493 -3.57418  -21.36593 1.000 21.20090 ? 26  THR   A N   1 
ATOM   181  C CA  . THR   A 1 26  ? -14.46262 -2.93061  -20.23509 1.000 21.40161 ? 26  THR   A CA  1 
ATOM   182  C C   . THR   A 1 26  ? -14.50384 -3.89855  -19.05376 1.000 17.99350 ? 26  THR   A C   1 
ATOM   183  O O   . THR   A 1 26  ? -14.81103 -5.08186  -19.22070 1.000 19.02719 ? 26  THR   A O   1 
ATOM   184  C CB  . THR   A 1 26  ? -15.86551 -2.44848  -20.62949 1.000 22.30817 ? 26  THR   A CB  1 
ATOM   185  O OG1 . THR   A 1 26  ? -15.75176 -1.29955  -21.48448 1.000 25.15391 ? 26  THR   A OG1 1 
ATOM   186  C CG2 . THR   A 1 26  ? -16.65124 -2.03317  -19.43462 1.000 25.13302 ? 26  THR   A CG2 1 
ATOM   187  N N   . LEU   A 1 27  ? -14.16223 -3.39983  -17.87478 1.000 14.95143 ? 27  LEU   A N   1 
ATOM   188  C CA  . LEU   A 1 27  ? -14.29006 -4.16395  -16.64059 1.000 16.64655 ? 27  LEU   A CA  1 
ATOM   189  C C   . LEU   A 1 27  ? -14.61755 -3.20143  -15.50657 1.000 14.44160 ? 27  LEU   A C   1 
ATOM   190  O O   . LEU   A 1 27  ? -14.92321 -2.02310  -15.73764 1.000 15.60560 ? 27  LEU   A O   1 
ATOM   191  C CB  . LEU   A 1 27  ? -13.02363 -5.00493  -16.41534 1.000 15.58941 ? 27  LEU   A CB  1 
ATOM   192  C CG  . LEU   A 1 27  ? -11.69437 -4.25490  -16.46583 1.000 11.40755 ? 27  LEU   A CG  1 
ATOM   193  C CD1 . LEU   A 1 27  ? -11.39840 -3.46741  -15.23483 1.000 15.68749 ? 27  LEU   A CD1 1 
ATOM   194  C CD2 . LEU   A 1 27  ? -10.68558 -5.37920  -16.57198 1.000 16.10260 ? 27  LEU   A CD2 1 
ATOM   195  N N   . ASN   A 1 28  ? -14.57999 -3.70832  -14.27294 1.000 12.77122 ? 28  ASN   A N   1 
ATOM   196  C CA  . ASN   A 1 28  ? -14.95115 -2.94610  -13.08478 1.000 11.21020 ? 28  ASN   A CA  1 
ATOM   197  C C   . ASN   A 1 28  ? -13.73789 -2.39611  -12.37765 1.000 9.80274  ? 28  ASN   A C   1 
ATOM   198  O O   . ASN   A 1 28  ? -12.69946 -3.05596  -12.29436 1.000 10.24486 ? 28  ASN   A O   1 
ATOM   199  C CB  . ASN   A 1 28  ? -15.69251 -3.84141  -12.09290 1.000 9.38517  ? 28  ASN   A CB  1 
ATOM   200  C CG  . ASN   A 1 28  ? -16.89893 -4.47377  -12.72137 1.000 13.79196 ? 28  ASN   A CG  1 
ATOM   201  O OD1 . ASN   A 1 28  ? -17.91761 -3.79132  -12.89647 1.000 12.65230 ? 28  ASN   A OD1 1 
ATOM   202  N ND2 . ASN   A 1 28  ? -16.77003 -5.74434  -13.18113 1.000 10.96782 ? 28  ASN   A ND2 1 
ATOM   203  N N   . GLY   A 1 29  ? -13.92432 -1.25092  -11.73151 1.000 8.11119  ? 29  GLY   A N   1 
ATOM   204  C CA  . GLY   A 1 29  ? -12.88311 -0.67628  -10.91064 1.000 11.77941 ? 29  GLY   A CA  1 
ATOM   205  C C   . GLY   A 1 29  ? -13.43621 -0.37532  -9.53779  1.000 11.68153 ? 29  GLY   A C   1 
ATOM   206  O O   . GLY   A 1 29  ? -14.64948 -0.32796  -9.33074  1.000 9.90069  ? 29  GLY   A O   1 
ATOM   207  N N   . LEU   A 1 30  ? -12.53280 -0.14649  -8.60504  1.000 11.11396 ? 30  LEU   A N   1 
ATOM   208  C CA  . LEU   A 1 30  ? -12.91369 0.16570   -7.23756  1.000 12.69453 ? 30  LEU   A CA  1 
ATOM   209  C C   . LEU   A 1 30  ? -12.39966 1.55202   -6.93571  1.000 13.74573 ? 30  LEU   A C   1 
ATOM   210  O O   . LEU   A 1 30  ? -11.18305 1.78244   -6.95719  1.000 12.02269 ? 30  LEU   A O   1 
ATOM   211  C CB  . LEU   A 1 30  ? -12.33121 -0.84034  -6.24871  1.000 8.77208  ? 30  LEU   A CB  1 
ATOM   212  C CG  . LEU   A 1 30  ? -12.70980 -0.65073  -4.76792  1.000 10.74363 ? 30  LEU   A CG  1 
ATOM   213  C CD1 . LEU   A 1 30  ? -14.11497 -1.16702  -4.54751  1.000 10.47572 ? 30  LEU   A CD1 1 
ATOM   214  C CD2 . LEU   A 1 30  ? -11.72997 -1.34056  -3.81992  1.000 11.19675 ? 30  LEU   A CD2 1 
ATOM   215  N N   . TRP   A 1 31  ? -13.32065 2.46072   -6.62879  1.000 12.32631 ? 31  TRP   A N   1 
ATOM   216  C CA  . TRP   A 1 31  ? -13.01839 3.88296   -6.48372  1.000 11.24906 ? 31  TRP   A CA  1 
ATOM   217  C C   . TRP   A 1 31  ? -12.97780 4.24250   -4.99447  1.000 15.24325 ? 31  TRP   A C   1 
ATOM   218  O O   . TRP   A 1 31  ? -14.02011 4.31300   -4.33363  1.000 12.56623 ? 31  TRP   A O   1 
ATOM   219  C CB  . TRP   A 1 31  ? -14.07608 4.68729   -7.23850  1.000 13.05746 ? 31  TRP   A CB  1 
ATOM   220  C CG  . TRP   A 1 31  ? -13.88510 6.16083   -7.21827  1.000 17.85225 ? 31  TRP   A CG  1 
ATOM   221  C CD1 . TRP   A 1 31  ? -12.70976 6.85253   -6.99314  1.000 17.30681 ? 31  TRP   A CD1 1 
ATOM   222  C CD2 . TRP   A 1 31  ? -14.89524 7.14343   -7.44861  1.000 18.33197 ? 31  TRP   A CD2 1 
ATOM   223  N NE1 . TRP   A 1 31  ? -12.94918 8.21132   -7.06132  1.000 16.16943 ? 31  TRP   A NE1 1 
ATOM   224  C CE2 . TRP   A 1 31  ? -14.27649 8.41277   -7.35864  1.000 21.86045 ? 31  TRP   A CE2 1 
ATOM   225  C CE3 . TRP   A 1 31  ? -16.26746 7.07308   -7.74564  1.000 19.31661 ? 31  TRP   A CE3 1 
ATOM   226  C CZ2 . TRP   A 1 31  ? -14.99309 9.60478   -7.52473  1.000 24.79226 ? 31  TRP   A CZ2 1 
ATOM   227  C CZ3 . TRP   A 1 31  ? -16.97204 8.24438   -7.91679  1.000 22.99100 ? 31  TRP   A CZ3 1 
ATOM   228  C CH2 . TRP   A 1 31  ? -16.33802 9.50116   -7.78843  1.000 23.90035 ? 31  TRP   A CH2 1 
ATOM   229  N N   . LEU   A 1 32  ? -11.78285 4.50307   -4.46488  1.000 12.21147 ? 32  LEU   A N   1 
ATOM   230  C CA  . LEU   A 1 32  ? -11.64071 4.91014   -3.07002  1.000 15.07131 ? 32  LEU   A CA  1 
ATOM   231  C C   . LEU   A 1 32  ? -10.84136 6.20298   -3.04442  1.000 18.19047 ? 32  LEU   A C   1 
ATOM   232  O O   . LEU   A 1 32  ? -9.79288  6.27904   -3.69049  1.000 16.16045 ? 32  LEU   A O   1 
ATOM   233  C CB  . LEU   A 1 32  ? -10.95340 3.82294   -2.23869  1.000 15.49082 ? 32  LEU   A CB  1 
ATOM   234  C CG  . LEU   A 1 32  ? -11.63934 2.46274   -2.25624  1.000 15.87697 ? 32  LEU   A CG  1 
ATOM   235  C CD1 . LEU   A 1 32  ? -10.67139 1.40168   -1.69934  1.000 11.56709 ? 32  LEU   A CD1 1 
ATOM   236  C CD2 . LEU   A 1 32  ? -12.93458 2.54677   -1.42543  1.000 14.34194 ? 32  LEU   A CD2 1 
ATOM   237  N N   . ASP   A 1 33  ? -11.34005 7.22027   -2.32198  1.000 17.74472 ? 33  ASP   A N   1 
ATOM   238  C CA  . ASP   A 1 33  ? -10.68724 8.52392   -2.34450  1.000 17.27197 ? 33  ASP   A CA  1 
ATOM   239  C C   . ASP   A 1 33  ? -10.50101 8.88060   -3.82259  1.000 18.98235 ? 33  ASP   A C   1 
ATOM   240  O O   . ASP   A 1 33  ? -11.40877 8.61364   -4.61589  1.000 19.01333 ? 33  ASP   A O   1 
ATOM   241  C CB  . ASP   A 1 33  ? -9.38951  8.47888   -1.52841  1.000 21.23428 ? 33  ASP   A CB  1 
ATOM   242  C CG  . ASP   A 1 33  ? -9.62184  8.04869   -0.06614  1.000 24.68053 ? 33  ASP   A CG  1 
ATOM   243  O OD1 . ASP   A 1 33  ? -10.49902 8.63605   0.59989   1.000 26.06411 ? 33  ASP   A OD1 1 
ATOM   244  O OD2 . ASP   A 1 33  ? -8.89669  7.16152   0.43602   1.000 29.11147 ? 33  ASP   A OD2 1 
ATOM   245  N N   . ASP   A 1 34  ? -9.34949  9.40697   -4.25678  1.000 20.20967 ? 34  ASP   A N   1 
ATOM   246  C CA  . ASP   A 1 34  ? -9.21382  9.78520   -5.66284  1.000 19.11098 ? 34  ASP   A CA  1 
ATOM   247  C C   . ASP   A 1 34  ? -8.45332  8.74907   -6.49367  1.000 19.23128 ? 34  ASP   A C   1 
ATOM   248  O O   . ASP   A 1 34  ? -7.75320  9.11776   -7.44192  1.000 19.29317 ? 34  ASP   A O   1 
ATOM   249  C CB  . ASP   A 1 34  ? -8.54814  11.16126  -5.81070  1.000 24.48835 ? 34  ASP   A CB  1 
ATOM   250  C CG  . ASP   A 1 34  ? -7.11067  11.19268  -5.29210  1.000 28.60589 ? 34  ASP   A CG  1 
ATOM   251  O OD1 . ASP   A 1 34  ? -6.70549  10.23949  -4.58504  1.000 27.08210 ? 34  ASP   A OD1 1 
ATOM   252  O OD2 . ASP   A 1 34  ? -6.39620  12.18566  -5.57264  1.000 30.80955 ? 34  ASP   A OD2 1 
ATOM   253  N N   . VAL   A 1 35  ? -8.57727  7.45588   -6.17433  1.000 17.02964 ? 35  VAL   A N   1 
ATOM   254  C CA  . VAL   A 1 35  ? -7.92237  6.38981   -6.94101  1.000 14.21832 ? 35  VAL   A CA  1 
ATOM   255  C C   . VAL   A 1 35  ? -8.94434  5.33500   -7.35545  1.000 14.84251 ? 35  VAL   A C   1 
ATOM   256  O O   . VAL   A 1 35  ? -9.87156  5.02553   -6.59944  1.000 13.01520 ? 35  VAL   A O   1 
ATOM   257  C CB  . VAL   A 1 35  ? -6.77751  5.74921   -6.12665  1.000 16.01788 ? 35  VAL   A CB  1 
ATOM   258  C CG1 . VAL   A 1 35  ? -6.17252  4.52944   -6.86453  1.000 15.49014 ? 35  VAL   A CG1 1 
ATOM   259  C CG2 . VAL   A 1 35  ? -5.72571  6.78610   -5.86207  1.000 21.06310 ? 35  VAL   A CG2 1 
ATOM   260  N N   . VAL   A 1 36  ? -8.79891  4.80973   -8.57800  1.000 11.74343 ? 36  VAL   A N   1 
ATOM   261  C CA  . VAL   A 1 36  ? -9.60704  3.70009   -9.06562  1.000 15.42306 ? 36  VAL   A CA  1 
ATOM   262  C C   . VAL   A 1 36  ? -8.66390  2.52521   -9.27098  1.000 16.49639 ? 36  VAL   A C   1 
ATOM   263  O O   . VAL   A 1 36  ? -7.65148  2.65626   -9.97521  1.000 14.53119 ? 36  VAL   A O   1 
ATOM   264  C CB  . VAL   A 1 36  ? -10.34237 4.05303   -10.37441 1.000 12.20025 ? 36  VAL   A CB  1 
ATOM   265  C CG1 . VAL   A 1 36  ? -10.95563 2.80865   -10.99119 1.000 15.84376 ? 36  VAL   A CG1 1 
ATOM   266  C CG2 . VAL   A 1 36  ? -11.40990 5.14273   -10.10247 1.000 16.05405 ? 36  VAL   A CG2 1 
ATOM   267  N N   . TYR   A 1 37  ? -8.97041  1.39989   -8.63120  1.000 12.06805 ? 37  TYR   A N   1 
ATOM   268  C CA  . TYR   A 1 37  ? -8.15320  0.19277   -8.70951  1.000 10.22210 ? 37  TYR   A CA  1 
ATOM   269  C C   . TYR   A 1 37  ? -8.81204  -0.77152  -9.66273  1.000 12.13245 ? 37  TYR   A C   1 
ATOM   270  O O   . TYR   A 1 37  ? -10.01634 -1.00198  -9.56180  1.000 11.72437 ? 37  TYR   A O   1 
ATOM   271  C CB  . TYR   A 1 37  ? -8.03600  -0.50043  -7.35435  1.000 7.57398  ? 37  TYR   A CB  1 
ATOM   272  C CG  . TYR   A 1 37  ? -7.43067  0.34555   -6.30743  1.000 11.91420 ? 37  TYR   A CG  1 
ATOM   273  C CD1 . TYR   A 1 37  ? -8.18034  1.29999   -5.62400  1.000 11.99559 ? 37  TYR   A CD1 1 
ATOM   274  C CD2 . TYR   A 1 37  ? -6.07661  0.21342   -6.00385  1.000 11.64269 ? 37  TYR   A CD2 1 
ATOM   275  C CE1 . TYR   A 1 37  ? -7.58737  2.07966   -4.65632  1.000 14.93038 ? 37  TYR   A CE1 1 
ATOM   276  C CE2 . TYR   A 1 37  ? -5.48366  0.99519   -5.03782  1.000 12.92834 ? 37  TYR   A CE2 1 
ATOM   277  C CZ  . TYR   A 1 37  ? -6.24605  1.91898   -4.37384  1.000 14.42581 ? 37  TYR   A CZ  1 
ATOM   278  O OH  . TYR   A 1 37  ? -5.69029  2.73897   -3.42521  1.000 17.45555 ? 37  TYR   A OH  1 
ATOM   279  N N   . CYS   A 1 38  ? -8.03762  -1.37650  -10.55365 1.000 10.85656 ? 38  CYS   A N   1 
ATOM   280  C CA  . CYS   A 1 38  ? -8.66366  -2.34704  -11.43722 1.000 10.78548 ? 38  CYS   A CA  1 
ATOM   281  C C   . CYS   A 1 38  ? -7.59737  -3.30163  -11.92148 1.000 11.49913 ? 38  CYS   A C   1 
ATOM   282  O O   . CYS   A 1 38  ? -6.39877  -3.02363  -11.76191 1.000 7.95964  ? 38  CYS   A O   1 
ATOM   283  C CB  . CYS   A 1 38  ? -9.35879  -1.66008  -12.61878 1.000 10.04790 ? 38  CYS   A CB  1 
ATOM   284  S SG  . CYS   A 1 38  ? -8.18398  -0.99872  -13.84876 1.000 16.93026 ? 38  CYS   A SG  1 
ATOM   285  N N   . PRO   A 1 39  ? -7.99227  -4.44548  -12.48671 1.000 8.39064  ? 39  PRO   A N   1 
ATOM   286  C CA  . PRO   A 1 39  ? -6.98830  -5.43243  -12.90793 1.000 11.64417 ? 39  PRO   A CA  1 
ATOM   287  C C   . PRO   A 1 39  ? -6.12785  -4.87409  -14.03785 1.000 15.92785 ? 39  PRO   A C   1 
ATOM   288  O O   . PRO   A 1 39  ? -6.64474  -4.23230  -14.95160 1.000 11.45100 ? 39  PRO   A O   1 
ATOM   289  C CB  . PRO   A 1 39  ? -7.84378  -6.59942  -13.40871 1.000 12.71300 ? 39  PRO   A CB  1 
ATOM   290  C CG  . PRO   A 1 39  ? -9.12358  -6.45736  -12.71263 1.000 8.73820  ? 39  PRO   A CG  1 
ATOM   291  C CD  . PRO   A 1 39  ? -9.36002  -4.98028  -12.63312 1.000 9.37380  ? 39  PRO   A CD  1 
ATOM   292  N N   . ARG   A 1 40  ? -4.81266  -5.14572  -13.99902 1.000 9.50927  ? 40  ARG   A N   1 
ATOM   293  C CA  . ARG   A 1 40  ? -3.96939  -4.52911  -15.01924 1.000 12.99678 ? 40  ARG   A CA  1 
ATOM   294  C C   . ARG   A 1 40  ? -4.22666  -5.11196  -16.39939 1.000 16.23693 ? 40  ARG   A C   1 
ATOM   295  O O   . ARG   A 1 40  ? -4.01786  -4.41988  -17.40498 1.000 14.79181 ? 40  ARG   A O   1 
ATOM   296  C CB  . ARG   A 1 40  ? -2.48905  -4.64869  -14.64691 1.000 11.04955 ? 40  ARG   A CB  1 
ATOM   297  C CG  . ARG   A 1 40  ? -1.89838  -6.00136  -14.76940 1.000 10.96079 ? 40  ARG   A CG  1 
ATOM   298  C CD  . ARG   A 1 40  ? -0.41062  -5.96626  -14.35837 1.000 12.82327 ? 40  ARG   A CD  1 
ATOM   299  N NE  . ARG   A 1 40  ? 0.10218   -7.33206  -14.33905 1.000 12.35422 ? 40  ARG   A NE  1 
ATOM   300  C CZ  . ARG   A 1 40  ? 1.38722   -7.66548  -14.20192 1.000 14.71990 ? 40  ARG   A CZ  1 
ATOM   301  N NH1 . ARG   A 1 40  ? 2.32686   -6.74070  -14.06919 1.000 13.92435 ? 40  ARG   A NH1 1 
ATOM   302  N NH2 . ARG   A 1 40  ? 1.73195   -8.93764  -14.22281 1.000 12.27857 ? 40  ARG   A NH2 1 
ATOM   303  N N   . HIS   A 1 41  ? -4.74352  -6.33091  -16.48086 1.000 14.94729 ? 41  HIS   A N   1 
ATOM   304  C CA  . HIS   A 1 41  ? -4.97523  -6.88825  -17.80712 1.000 16.51179 ? 41  HIS   A CA  1 
ATOM   305  C C   . HIS   A 1 41  ? -6.02506  -6.10046  -18.60719 1.000 19.09683 ? 41  HIS   A C   1 
ATOM   306  O O   . HIS   A 1 41  ? -6.22859  -6.40579  -19.78353 1.000 21.48135 ? 41  HIS   A O   1 
ATOM   307  C CB  . HIS   A 1 41  ? -5.31017  -8.39587  -17.73210 1.000 16.32256 ? 41  HIS   A CB  1 
ATOM   308  C CG  . HIS   A 1 41  ? -6.70297  -8.72246  -17.27179 1.000 20.86308 ? 41  HIS   A CG  1 
ATOM   309  N ND1 . HIS   A 1 41  ? -6.97425  -9.39327  -16.09718 1.000 19.40215 ? 41  HIS   A ND1 1 
ATOM   310  C CD2 . HIS   A 1 41  ? -7.90555  -8.46097  -17.82970 1.000 21.19339 ? 41  HIS   A CD2 1 
ATOM   311  C CE1 . HIS   A 1 41  ? -8.28428  -9.54361  -15.96509 1.000 16.87992 ? 41  HIS   A CE1 1 
ATOM   312  N NE2 . HIS   A 1 41  ? -8.87396  -8.96865  -16.99454 1.000 21.46376 ? 41  HIS   A NE2 1 
ATOM   313  N N   . VAL   A 1 42  ? -6.63861  -5.04874  -18.03449 1.000 13.34125 ? 42  VAL   A N   1 
ATOM   314  C CA  . VAL   A 1 42  ? -7.50242  -4.15870  -18.82968 1.000 17.17547 ? 42  VAL   A CA  1 
ATOM   315  C C   . VAL   A 1 42  ? -6.75088  -3.49554  -19.98682 1.000 22.59175 ? 42  VAL   A C   1 
ATOM   316  O O   . VAL   A 1 42  ? -7.36615  -3.10977  -20.98963 1.000 22.56960 ? 42  VAL   A O   1 
ATOM   317  C CB  . VAL   A 1 42  ? -8.15921  -3.07935  -17.94748 1.000 19.83470 ? 42  VAL   A CB  1 
ATOM   318  C CG1 . VAL   A 1 42  ? -7.14740  -2.02186  -17.54411 1.000 15.91338 ? 42  VAL   A CG1 1 
ATOM   319  C CG2 . VAL   A 1 42  ? -9.30966  -2.40828  -18.70862 1.000 19.25249 ? 42  VAL   A CG2 1 
ATOM   320  N N   . ILE   A 1 43  ? -5.42726  -3.31951  -19.87291 1.000 21.61383 ? 43  ILE   A N   1 
ATOM   321  C CA  . ILE   A 1 43  ? -4.68886  -2.62552  -20.93135 1.000 24.55173 ? 43  ILE   A CA  1 
ATOM   322  C C   . ILE   A 1 43  ? -4.28442  -3.56267  -22.04318 1.000 24.84125 ? 43  ILE   A C   1 
ATOM   323  O O   . ILE   A 1 43  ? -3.60946  -3.13369  -22.98826 1.000 30.04902 ? 43  ILE   A O   1 
ATOM   324  C CB  . ILE   A 1 43  ? -3.41292  -1.92100  -20.42117 1.000 17.99785 ? 43  ILE   A CB  1 
ATOM   325  C CG1 . ILE   A 1 43  ? -2.38426  -2.94311  -19.90454 1.000 21.02291 ? 43  ILE   A CG1 1 
ATOM   326  C CG2 . ILE   A 1 43  ? -3.75385  -0.91088  -19.33886 1.000 19.28864 ? 43  ILE   A CG2 1 
ATOM   327  C CD1 . ILE   A 1 43  ? -1.03429  -2.31460  -19.56486 1.000 15.88279 ? 43  ILE   A CD1 1 
ATOM   328  N N   . CYS   A 1 44  ? -4.64123  -4.83374  -21.94510 1.000 25.45984 ? 44  CYS   A N   1 
ATOM   329  C CA  . CYS   A 1 44  ? -4.28107  -5.83240  -22.93204 1.000 27.40305 ? 44  CYS   A CA  1 
ATOM   330  C C   . CYS   A 1 44  ? -5.35997  -5.98939  -23.98447 1.000 38.52156 ? 44  CYS   A C   1 
ATOM   331  O O   . CYS   A 1 44  ? -6.54263  -5.74309  -23.74090 1.000 40.13553 ? 44  CYS   A O   1 
ATOM   332  C CB  . CYS   A 1 44  ? -4.05898  -7.18986  -22.28297 1.000 34.04920 ? 44  CYS   A CB  1 
ATOM   333  S SG  . CYS   A 1 44  ? -2.67799  -7.25663  -21.15927 1.000 31.66908 ? 44  CYS   A SG  1 
ATOM   334  N N   . THR   A 1 45  ? -4.93961  -6.43951  -25.15452 1.000 41.90709 ? 45  THR   A N   1 
ATOM   335  C CA  . THR   A 1 45  ? -5.86265  -6.83709  -26.19655 1.000 49.73237 ? 45  THR   A CA  1 
ATOM   336  C C   . THR   A 1 45  ? -5.81183  -8.34572  -26.33348 1.000 53.96269 ? 45  THR   A C   1 
ATOM   337  O O   . THR   A 1 45  ? -4.99170  -9.01651  -25.70341 1.000 50.75435 ? 45  THR   A O   1 
ATOM   338  C CB  . THR   A 1 45  ? -5.52408  -6.16482  -27.52762 1.000 52.79721 ? 45  THR   A CB  1 
ATOM   339  O OG1 . THR   A 1 45  ? -4.11621  -6.29775  -27.79175 1.000 41.45101 ? 45  THR   A OG1 1 
ATOM   340  C CG2 . THR   A 1 45  ? -5.95873  -4.67616  -27.48041 1.000 53.89111 ? 45  THR   A CG2 1 
ATOM   341  N N   . SER   A 1 46  ? -6.70376  -8.86309  -27.17970 1.000 59.72571 ? 46  SER   A N   1 
ATOM   342  C CA  . SER   A 1 46  ? -6.82809  -10.30449 -27.36587 1.000 62.67255 ? 46  SER   A CA  1 
ATOM   343  C C   . SER   A 1 46  ? -5.46629  -10.95382 -27.61963 1.000 59.79187 ? 46  SER   A C   1 
ATOM   344  O O   . SER   A 1 46  ? -5.08235  -11.90767 -26.93404 1.000 57.33614 ? 46  SER   A O   1 
ATOM   345  C CB  . SER   A 1 46  ? -7.80974  -10.57813 -28.50793 1.000 63.38640 ? 46  SER   A CB  1 
ATOM   346  O OG  . SER   A 1 46  ? -9.11723  -10.14730 -28.14772 1.000 66.05992 ? 46  SER   A OG  1 
ATOM   347  N N   . GLU   A 1 47  ? -4.70091  -10.42312 -28.57440 1.000 59.39584 ? 47  GLU   A N   1 
ATOM   348  C CA  . GLU   A 1 47  ? -3.36128  -10.94554 -28.82089 1.000 59.47735 ? 47  GLU   A CA  1 
ATOM   349  C C   . GLU   A 1 47  ? -2.33975  -10.50508 -27.76918 1.000 59.29855 ? 47  GLU   A C   1 
ATOM   350  O O   . GLU   A 1 47  ? -1.27506  -11.12511 -27.66780 1.000 58.92219 ? 47  GLU   A O   1 
ATOM   351  C CB  . GLU   A 1 47  ? -2.89874  -10.55157 -30.23097 1.000 60.20515 ? 47  GLU   A CB  1 
ATOM   352  C CG  . GLU   A 1 47  ? -2.80446  -9.04640  -30.47481 1.000 62.39856 ? 47  GLU   A CG  1 
ATOM   353  C CD  . GLU   A 1 47  ? -4.08487  -8.45809  -31.07180 1.000 65.31260 ? 47  GLU   A CD  1 
ATOM   354  O OE1 . GLU   A 1 47  ? -5.19937  -8.85323  -30.64741 1.000 65.08983 ? 47  GLU   A OE1 1 
ATOM   355  O OE2 . GLU   A 1 47  ? -3.97271  -7.60306  -31.97745 1.000 63.25465 ? 47  GLU   A OE2 1 
ATOM   356  N N   . ASP   A 1 48  ? -2.63338  -9.47011  -26.97034 1.000 57.05627 ? 48  ASP   A N   1 
ATOM   357  C CA  . ASP   A 1 48  ? -1.72669  -9.10903  -25.87422 1.000 55.20050 ? 48  ASP   A CA  1 
ATOM   358  C C   . ASP   A 1 48  ? -1.74231  -10.15102 -24.76065 1.000 53.59525 ? 48  ASP   A C   1 
ATOM   359  O O   . ASP   A 1 48  ? -0.68551  -10.51695 -24.23111 1.000 48.25728 ? 48  ASP   A O   1 
ATOM   360  C CB  . ASP   A 1 48  ? -2.09545  -7.74305  -25.28665 1.000 48.95830 ? 48  ASP   A CB  1 
ATOM   361  C CG  . ASP   A 1 48  ? -1.46367  -6.56902  -26.03163 1.000 45.14811 ? 48  ASP   A CG  1 
ATOM   362  O OD1 . ASP   A 1 48  ? -0.47223  -6.76753  -26.77453 1.000 44.18715 ? 48  ASP   A OD1 1 
ATOM   363  O OD2 . ASP   A 1 48  ? -1.98527  -5.44143  -25.87775 1.000 39.64595 ? 48  ASP   A OD2 1 
ATOM   364  N N   . MET   A 1 49  ? -2.94534  -10.62978 -24.37102 1.000 61.90552 ? 49  MET   A N   1 
ATOM   365  C CA  . MET   A 1 49  ? -3.10169  -11.46547 -23.16725 1.000 58.69077 ? 49  MET   A CA  1 
ATOM   366  C C   . MET   A 1 49  ? -2.50415  -12.83190 -23.31976 1.000 54.66517 ? 49  MET   A C   1 
ATOM   367  O O   . MET   A 1 49  ? -2.69536  -13.62670 -22.39748 1.000 55.84210 ? 49  MET   A O   1 
ATOM   368  C CB  . MET   A 1 49  ? -4.57796  -11.60882 -22.77001 1.000 56.83682 ? 49  MET   A CB  1 
ATOM   369  C CG  . MET   A 1 49  ? -5.41489  -10.33407 -22.85477 1.000 57.63792 ? 49  MET   A CG  1 
ATOM   370  S SD  . MET   A 1 49  ? -7.21321  -10.55893 -22.70024 1.000 63.47172 ? 49  MET   A SD  1 
ATOM   371  C CE  . MET   A 1 49  ? -7.71025  -8.90891  -22.23260 1.000 56.05034 ? 49  MET   A CE  1 
ATOM   372  N N   . LEU   A 1 50  ? -1.81271  -13.13587 -24.41924 1.000 56.26595 ? 50  LEU   A N   1 
ATOM   373  C CA  . LEU   A 1 50  ? -1.15027  -14.43284 -24.56870 1.000 56.39911 ? 50  LEU   A CA  1 
ATOM   374  C C   . LEU   A 1 50  ? 0.10555   -14.47773 -23.70156 1.000 51.60477 ? 50  LEU   A C   1 
ATOM   375  O O   . LEU   A 1 50  ? 0.15991   -15.20497 -22.70566 1.000 51.46311 ? 50  LEU   A O   1 
ATOM   376  C CB  . LEU   A 1 50  ? -0.82424  -14.68780 -26.04509 1.000 60.04128 ? 50  LEU   A CB  1 
ATOM   377  C CG  . LEU   A 1 50  ? -2.01514  -14.82864 -27.01022 1.000 60.75031 ? 50  LEU   A CG  1 
ATOM   378  C CD1 . LEU   A 1 50  ? -1.54586  -14.81607 -28.46818 1.000 58.83919 ? 50  LEU   A CD1 1 
ATOM   379  C CD2 . LEU   A 1 50  ? -2.90857  -16.05599 -26.72364 1.000 57.21248 ? 50  LEU   A CD2 1 
ATOM   380  N N   . ASN   A 1 51  ? 1.12206   -13.68944 -24.05102 1.000 51.46581 ? 51  ASN   A N   1 
ATOM   381  C CA  . ASN   A 1 51  ? 2.27648   -13.49225 -23.17206 1.000 49.09736 ? 51  ASN   A CA  1 
ATOM   382  C C   . ASN   A 1 51  ? 2.65100   -12.01306 -23.12586 1.000 46.70481 ? 51  ASN   A C   1 
ATOM   383  O O   . ASN   A 1 51  ? 3.50701   -11.55069 -23.88742 1.000 48.55245 ? 51  ASN   A O   1 
ATOM   384  C CB  . ASN   A 1 51  ? 3.46189   -14.35484 -23.61139 1.000 52.34744 ? 51  ASN   A CB  1 
ATOM   385  C CG  . ASN   A 1 51  ? 4.41835   -14.67469 -22.46109 1.000 53.36959 ? 51  ASN   A CG  1 
ATOM   386  O OD1 . ASN   A 1 51  ? 4.38521   -14.04105 -21.39947 1.000 56.09573 ? 51  ASN   A OD1 1 
ATOM   387  N ND2 . ASN   A 1 51  ? 5.26263   -15.67952 -22.66458 1.000 53.22746 ? 51  ASN   A ND2 1 
ATOM   388  N N   . PRO   A 1 52  ? 2.04109   -11.23650 -22.22864 1.000 42.23427 ? 52  PRO   A N   1 
ATOM   389  C CA  . PRO   A 1 52  ? 2.26278   -9.78589  -22.24217 1.000 38.73377 ? 52  PRO   A CA  1 
ATOM   390  C C   . PRO   A 1 52  ? 3.44377   -9.32170  -21.40861 1.000 36.40718 ? 52  PRO   A C   1 
ATOM   391  O O   . PRO   A 1 52  ? 3.83279   -9.94336  -20.42222 1.000 34.78167 ? 52  PRO   A O   1 
ATOM   392  C CB  . PRO   A 1 52  ? 0.96599   -9.22841  -21.63646 1.000 35.69684 ? 52  PRO   A CB  1 
ATOM   393  C CG  . PRO   A 1 52  ? 0.48064   -10.30810 -20.70940 1.000 39.28017 ? 52  PRO   A CG  1 
ATOM   394  C CD  . PRO   A 1 52  ? 1.01702   -11.62699 -21.24520 1.000 40.60679 ? 52  PRO   A CD  1 
ATOM   395  N N   . ASN   A 1 53  ? 3.99241   -8.16783  -21.79170 1.000 28.06998 ? 53  ASN   A N   1 
ATOM   396  C CA  . ASN   A 1 53  ? 4.95395   -7.46437  -20.95208 1.000 28.72304 ? 53  ASN   A CA  1 
ATOM   397  C C   . ASN   A 1 53  ? 4.24455   -6.19851  -20.48463 1.000 30.17932 ? 53  ASN   A C   1 
ATOM   398  O O   . ASN   A 1 53  ? 4.00483   -5.27649  -21.27800 1.000 26.55015 ? 53  ASN   A O   1 
ATOM   399  C CB  . ASN   A 1 53  ? 6.25452   -7.19217  -21.71169 1.000 29.37984 ? 53  ASN   A CB  1 
ATOM   400  C CG  . ASN   A 1 53  ? 7.24770   -6.36429  -20.91822 1.000 31.70336 ? 53  ASN   A CG  1 
ATOM   401  O OD1 . ASN   A 1 53  ? 6.89116   -5.42844  -20.22115 1.000 33.28571 ? 53  ASN   A OD1 1 
ATOM   402  N ND2 . ASN   A 1 53  ? 8.51548   -6.73526  -21.00558 1.000 41.02288 ? 53  ASN   A ND2 1 
ATOM   403  N N   . TYR   A 1 54  ? 3.85891   -6.17610  -19.20609 1.000 23.48836 ? 54  TYR   A N   1 
ATOM   404  C CA  . TYR   A 1 54  ? 2.95584   -5.13015  -18.76902 1.000 20.56931 ? 54  TYR   A CA  1 
ATOM   405  C C   . TYR   A 1 54  ? 3.67132   -3.80603  -18.61132 1.000 21.07624 ? 54  TYR   A C   1 
ATOM   406  O O   . TYR   A 1 54  ? 3.05200   -2.74451  -18.73558 1.000 19.34674 ? 54  TYR   A O   1 
ATOM   407  C CB  . TYR   A 1 54  ? 2.28463   -5.54700  -17.46424 1.000 17.10500 ? 54  TYR   A CB  1 
ATOM   408  C CG  . TYR   A 1 54  ? 1.15543   -6.53601  -17.65761 1.000 14.86997 ? 54  TYR   A CG  1 
ATOM   409  C CD1 . TYR   A 1 54  ? -0.11461  -6.09831  -18.02397 1.000 16.62412 ? 54  TYR   A CD1 1 
ATOM   410  C CD2 . TYR   A 1 54  ? 1.36138   -7.91801  -17.47554 1.000 17.00569 ? 54  TYR   A CD2 1 
ATOM   411  C CE1 . TYR   A 1 54  ? -1.14696  -6.97765  -18.16982 1.000 16.90097 ? 54  TYR   A CE1 1 
ATOM   412  C CE2 . TYR   A 1 54  ? 0.34249   -8.81000  -17.65536 1.000 17.75801 ? 54  TYR   A CE2 1 
ATOM   413  C CZ  . TYR   A 1 54  ? -0.91018  -8.31996  -18.00540 1.000 16.21020 ? 54  TYR   A CZ  1 
ATOM   414  O OH  . TYR   A 1 54  ? -1.95183  -9.15497  -18.16966 1.000 19.83605 ? 54  TYR   A OH  1 
ATOM   415  N N   . GLU   A 1 55  ? 4.96091   -3.83191  -18.31935 1.000 22.38183 ? 55  GLU   A N   1 
ATOM   416  C CA  . GLU   A 1 55  ? 5.66218   -2.56504  -18.25733 1.000 26.19834 ? 55  GLU   A CA  1 
ATOM   417  C C   . GLU   A 1 55  ? 5.70038   -1.94074  -19.64527 1.000 21.23025 ? 55  GLU   A C   1 
ATOM   418  O O   . GLU   A 1 55  ? 5.38387   -0.75985  -19.80592 1.000 22.96084 ? 55  GLU   A O   1 
ATOM   419  C CB  . GLU   A 1 55  ? 7.05370   -2.76985  -17.66223 1.000 27.06590 ? 55  GLU   A CB  1 
ATOM   420  C CG  . GLU   A 1 55  ? 6.98914   -3.09639  -16.16884 1.000 33.17791 ? 55  GLU   A CG  1 
ATOM   421  C CD  . GLU   A 1 55  ? 6.77378   -4.60801  -15.87595 1.000 39.75979 ? 55  GLU   A CD  1 
ATOM   422  O OE1 . GLU   A 1 55  ? 6.80931   -5.47534  -16.80666 1.000 36.88507 ? 55  GLU   A OE1 1 
ATOM   423  O OE2 . GLU   A 1 55  ? 6.56249   -4.91975  -14.67945 1.000 44.96578 ? 55  GLU   A OE2 1 
ATOM   424  N N   . ASP   A 1 56  ? 5.99691   -2.74953  -20.66416 1.000 22.09426 ? 56  ASP   A N   1 
ATOM   425  C CA  . ASP   A 1 56  ? 5.94568   -2.28783  -22.04991 1.000 25.01822 ? 56  ASP   A CA  1 
ATOM   426  C C   . ASP   A 1 56  ? 4.55197   -1.78639  -22.41888 1.000 25.43749 ? 56  ASP   A C   1 
ATOM   427  O O   . ASP   A 1 56  ? 4.39106   -0.67460  -22.94201 1.000 21.01357 ? 56  ASP   A O   1 
ATOM   428  C CB  . ASP   A 1 56  ? 6.36024   -3.43211  -22.97127 1.000 26.74790 ? 56  ASP   A CB  1 
ATOM   429  C CG  . ASP   A 1 56  ? 7.85701   -3.49525  -23.18454 1.000 30.88333 ? 56  ASP   A CG  1 
ATOM   430  O OD1 . ASP   A 1 56  ? 8.59467   -2.73663  -22.51430 1.000 32.57275 ? 56  ASP   A OD1 1 
ATOM   431  O OD2 . ASP   A 1 56  ? 8.28795   -4.34512  -23.99345 1.000 37.09728 ? 56  ASP   A OD2 1 
ATOM   432  N N   . LEU   A 1 57  ? 3.52784   -2.59906  -22.16064 1.000 21.64860 ? 57  LEU   A N   1 
ATOM   433  C CA  . LEU   A 1 57  ? 2.17634   -2.20148  -22.53143 1.000 20.11899 ? 57  LEU   A CA  1 
ATOM   434  C C   . LEU   A 1 57  ? 1.76954   -0.90065  -21.84761 1.000 22.46182 ? 57  LEU   A C   1 
ATOM   435  O O   . LEU   A 1 57  ? 1.13086   -0.04424  -22.47175 1.000 17.94685 ? 57  LEU   A O   1 
ATOM   436  C CB  . LEU   A 1 57  ? 1.18620   -3.32470  -22.20233 1.000 19.92187 ? 57  LEU   A CB  1 
ATOM   437  C CG  . LEU   A 1 57  ? 1.32088   -4.61927  -23.02162 1.000 25.91123 ? 57  LEU   A CG  1 
ATOM   438  C CD1 . LEU   A 1 57  ? 0.21024   -5.61601  -22.66896 1.000 29.00088 ? 57  LEU   A CD1 1 
ATOM   439  C CD2 . LEU   A 1 57  ? 1.33234   -4.37375  -24.52908 1.000 28.81480 ? 57  LEU   A CD2 1 
ATOM   440  N N   . LEU   A 1 58  ? 2.14551   -0.71772  -20.57281 1.000 19.91116 ? 58  LEU   A N   1 
ATOM   441  C CA  . LEU   A 1 58  ? 1.65643   0.44379   -19.82558 1.000 16.90401 ? 58  LEU   A CA  1 
ATOM   442  C C   . LEU   A 1 58  ? 2.35665   1.74250   -20.23925 1.000 21.16547 ? 58  LEU   A C   1 
ATOM   443  O O   . LEU   A 1 58  ? 1.70127   2.78446   -20.33579 1.000 17.03040 ? 58  LEU   A O   1 
ATOM   444  C CB  . LEU   A 1 58  ? 1.79906   0.22880   -18.31255 1.000 20.17110 ? 58  LEU   A CB  1 
ATOM   445  C CG  . LEU   A 1 58  ? 1.10068   1.33506   -17.49993 1.000 21.01665 ? 58  LEU   A CG  1 
ATOM   446  C CD1 . LEU   A 1 58  ? -0.35920  1.43004   -17.91672 1.000 21.56506 ? 58  LEU   A CD1 1 
ATOM   447  C CD2 . LEU   A 1 58  ? 1.24228   1.15143   -16.00140 1.000 22.16397 ? 58  LEU   A CD2 1 
ATOM   448  N N   . ILE   A 1 59  ? 3.68783   1.72395   -20.45013 1.000 18.88466 ? 59  ILE   A N   1 
ATOM   449  C CA  . ILE   A 1 59  ? 4.39467   2.92620   -20.92307 1.000 18.14778 ? 59  ILE   A CA  1 
ATOM   450  C C   . ILE   A 1 59  ? 3.79850   3.45567   -22.23446 1.000 19.11464 ? 59  ILE   A C   1 
ATOM   451  O O   . ILE   A 1 59  ? 3.83522   4.66362   -22.50057 1.000 20.49922 ? 59  ILE   A O   1 
ATOM   452  C CB  . ILE   A 1 59  ? 5.92411   2.64295   -21.04264 1.000 20.49967 ? 59  ILE   A CB  1 
ATOM   453  C CG1 . ILE   A 1 59  ? 6.72240   3.91405   -21.26876 1.000 23.17296 ? 59  ILE   A CG1 1 
ATOM   454  C CG2 . ILE   A 1 59  ? 6.26508   1.77780   -22.19849 1.000 19.87467 ? 59  ILE   A CG2 1 
ATOM   455  C CD1 . ILE   A 1 59  ? 6.47325   4.97024   -20.23355 1.000 29.19729 ? 59  ILE   A CD1 1 
ATOM   456  N N   . ARG   A 1 60  ? 3.18870   2.58789   -23.04197 1.000 16.03576 ? 60  ARG   A N   1 
ATOM   457  C CA  . ARG   A 1 60  ? 2.58760   3.04140   -24.29428 1.000 18.76077 ? 60  ARG   A CA  1 
ATOM   458  C C   . ARG   A 1 60  ? 1.19774   3.62712   -24.11408 1.000 22.04875 ? 60  ARG   A C   1 
ATOM   459  O O   . ARG   A 1 60  ? 0.56881   4.01099   -25.10789 1.000 20.21762 ? 60  ARG   A O   1 
ATOM   460  C CB  . ARG   A 1 60  ? 2.51523   1.88203   -25.28232 1.000 19.62647 ? 60  ARG   A CB  1 
ATOM   461  C CG  . ARG   A 1 60  ? 3.87746   1.42152   -25.73285 1.000 19.92045 ? 60  ARG   A CG  1 
ATOM   462  C CD  . ARG   A 1 60  ? 3.84859   -0.03163  -26.12024 1.000 23.44799 ? 60  ARG   A CD  1 
ATOM   463  N NE  . ARG   A 1 60  ? 5.20895   -0.52065  -26.30016 1.000 27.85199 ? 60  ARG   A NE  1 
ATOM   464  C CZ  . ARG   A 1 60  ? 5.51489   -1.77021  -26.61196 1.000 30.18142 ? 60  ARG   A CZ  1 
ATOM   465  N NH1 . ARG   A 1 60  ? 4.54413   -2.66001  -26.76033 1.000 31.09860 ? 60  ARG   A NH1 1 
ATOM   466  N NH2 . ARG   A 1 60  ? 6.78837   -2.13211  -26.73908 1.000 29.13127 ? 60  ARG   A NH2 1 
ATOM   467  N N   . LYS   A 1 61  ? 0.68583   3.66346   -22.88755 1.000 23.24088 ? 61  LYS   A N   1 
ATOM   468  C CA  . LYS   A 1 61  ? -0.64041  4.18168   -22.60765 1.000 21.90411 ? 61  LYS   A CA  1 
ATOM   469  C C   . LYS   A 1 61  ? -0.52995  5.60384   -22.08727 1.000 22.12446 ? 61  LYS   A C   1 
ATOM   470  O O   . LYS   A 1 61  ? 0.51080   6.01197   -21.57512 1.000 21.65578 ? 61  LYS   A O   1 
ATOM   471  C CB  . LYS   A 1 61  ? -1.37371  3.29850   -21.58445 1.000 22.09124 ? 61  LYS   A CB  1 
ATOM   472  C CG  . LYS   A 1 61  ? -1.61817  1.87907   -22.10178 1.000 18.12190 ? 61  LYS   A CG  1 
ATOM   473  C CD  . LYS   A 1 61  ? -2.66059  1.90493   -23.23108 1.000 24.97114 ? 61  LYS   A CD  1 
ATOM   474  C CE  . LYS   A 1 61  ? -2.93935  0.51518   -23.74450 1.000 27.20152 ? 61  LYS   A CE  1 
ATOM   475  N NZ  . LYS   A 1 61  ? -3.86760  0.51990   -24.87966 1.000 31.43722 ? 61  LYS   A NZ  1 
ATOM   476  N N   . SER   A 1 62  ? -1.64369  6.33875   -22.19602 1.000 24.03617 ? 62  SER   A N   1 
ATOM   477  C CA  . SER   A 1 62  ? -1.81083  7.71259   -21.73819 1.000 27.75873 ? 62  SER   A CA  1 
ATOM   478  C C   . SER   A 1 62  ? -2.99207  7.78474   -20.76217 1.000 23.41104 ? 62  SER   A C   1 
ATOM   479  O O   . SER   A 1 62  ? -3.87541  6.93214   -20.79548 1.000 24.17256 ? 62  SER   A O   1 
ATOM   480  C CB  . SER   A 1 62  ? -2.08079  8.62973   -22.94371 1.000 30.36315 ? 62  SER   A CB  1 
ATOM   481  O OG  . SER   A 1 62  ? -0.98923  8.62270   -23.85066 1.000 36.19227 ? 62  SER   A OG  1 
ATOM   482  N N   . ASN   A 1 63  ? -3.03454  8.81294   -19.90358 1.000 22.87693 ? 63  ASN   A N   1 
ATOM   483  C CA  . ASN   A 1 63  ? -4.23048  9.01148   -19.07639 1.000 22.31051 ? 63  ASN   A CA  1 
ATOM   484  C C   . ASN   A 1 63  ? -5.52188  8.95795   -19.89667 1.000 28.04248 ? 63  ASN   A C   1 
ATOM   485  O O   . ASN   A 1 63  ? -6.52382  8.39571   -19.44332 1.000 25.76947 ? 63  ASN   A O   1 
ATOM   486  C CB  . ASN   A 1 63  ? -4.18131  10.34609  -18.34433 1.000 24.77112 ? 63  ASN   A CB  1 
ATOM   487  C CG  . ASN   A 1 63  ? -3.20393  10.36542  -17.21088 1.000 26.07163 ? 63  ASN   A CG  1 
ATOM   488  O OD1 . ASN   A 1 63  ? -2.76233  9.32163   -16.70985 1.000 24.97387 ? 63  ASN   A OD1 1 
ATOM   489  N ND2 . ASN   A 1 63  ? -2.85282  11.58101  -16.78059 1.000 22.00254 ? 63  ASN   A ND2 1 
ATOM   490  N N   . HIS   A 1 64  ? -5.53404  9.55213   -21.09786 1.000 27.40176 ? 64  HIS   A N   1 
ATOM   491  C CA  . HIS   A 1 64  ? -6.78483  9.61787   -21.85120 1.000 26.05793 ? 64  HIS   A CA  1 
ATOM   492  C C   . HIS   A 1 64  ? -7.17570  8.28440   -22.48132 1.000 27.01571 ? 64  HIS   A C   1 
ATOM   493  O O   . HIS   A 1 64  ? -8.30681  8.14669   -22.96460 1.000 27.51438 ? 64  HIS   A O   1 
ATOM   494  C CB  . HIS   A 1 64  ? -6.70435  10.70706  -22.91995 1.000 31.18490 ? 64  HIS   A CB  1 
ATOM   495  C CG  . HIS   A 1 64  ? -5.71797  10.41123  -23.99706 1.000 31.05490 ? 64  HIS   A CG  1 
ATOM   496  N ND1 . HIS   A 1 64  ? -5.92262  9.42674   -24.93960 1.000 36.20436 ? 64  HIS   A ND1 1 
ATOM   497  C CD2 . HIS   A 1 64  ? -4.49962  10.94077  -24.26135 1.000 35.47899 ? 64  HIS   A CD2 1 
ATOM   498  C CE1 . HIS   A 1 64  ? -4.87865  9.37344   -25.75052 1.000 36.74785 ? 64  HIS   A CE1 1 
ATOM   499  N NE2 . HIS   A 1 64  ? -4.00195  10.28308  -25.36173 1.000 34.97466 ? 64  HIS   A NE2 1 
ATOM   500  N N   . ASN   A 1 65  ? -6.30429  7.28363   -22.45229 1.000 23.16306 ? 65  ASN   A N   1 
ATOM   501  C CA  . ASN   A 1 65  ? -6.73652  5.97526   -22.91254 1.000 23.82558 ? 65  ASN   A CA  1 
ATOM   502  C C   . ASN   A 1 65  ? -7.63617  5.25999   -21.91004 1.000 24.76114 ? 65  ASN   A C   1 
ATOM   503  O O   . ASN   A 1 65  ? -8.18989  4.20779   -22.25273 1.000 24.42638 ? 65  ASN   A O   1 
ATOM   504  C CB  . ASN   A 1 65  ? -5.54476  5.06113   -23.22105 1.000 24.70097 ? 65  ASN   A CB  1 
ATOM   505  C CG  . ASN   A 1 65  ? -4.58556  5.64291   -24.23175 1.000 29.61803 ? 65  ASN   A CG  1 
ATOM   506  O OD1 . ASN   A 1 65  ? -3.40070  5.78917   -23.95980 1.000 27.68523 ? 65  ASN   A OD1 1 
ATOM   507  N ND2 . ASN   A 1 65  ? -5.09670  5.97609   -25.41179 1.000 33.62314 ? 65  ASN   A ND2 1 
ATOM   508  N N   . PHE   A 1 66  ? -7.78129  5.77956   -20.69364 1.000 21.51537 ? 66  PHE   A N   1 
ATOM   509  C CA  . PHE   A 1 66  ? -8.60795  5.14707   -19.66493 1.000 24.55896 ? 66  PHE   A CA  1 
ATOM   510  C C   . PHE   A 1 66  ? -9.88896  5.95377   -19.47098 1.000 23.79060 ? 66  PHE   A C   1 
ATOM   511  O O   . PHE   A 1 66  ? -9.85310  7.10457   -19.04713 1.000 24.20240 ? 66  PHE   A O   1 
ATOM   512  C CB  . PHE   A 1 66  ? -7.86898  5.02136   -18.33003 1.000 19.96553 ? 66  PHE   A CB  1 
ATOM   513  C CG  . PHE   A 1 66  ? -6.59196  4.22992   -18.40485 1.000 19.18865 ? 66  PHE   A CG  1 
ATOM   514  C CD1 . PHE   A 1 66  ? -6.60886  2.84935   -18.38072 1.000 20.41185 ? 66  PHE   A CD1 1 
ATOM   515  C CD2 . PHE   A 1 66  ? -5.37623  4.87296   -18.47734 1.000 21.11135 ? 66  PHE   A CD2 1 
ATOM   516  C CE1 . PHE   A 1 66  ? -5.43987  2.13014   -18.44541 1.000 21.31657 ? 66  PHE   A CE1 1 
ATOM   517  C CE2 . PHE   A 1 66  ? -4.19301  4.14740   -18.54401 1.000 20.39368 ? 66  PHE   A CE2 1 
ATOM   518  C CZ  . PHE   A 1 66  ? -4.22697  2.78136   -18.51076 1.000 20.86966 ? 66  PHE   A CZ  1 
ATOM   519  N N   . LEU   A 1 67  ? -10.99537 5.32872   -19.75831 1.000 24.84551 ? 67  LEU   A N   1 
ATOM   520  C CA  . LEU   A 1 67  ? -12.33726 5.84998   -19.58286 1.000 26.55745 ? 67  LEU   A CA  1 
ATOM   521  C C   . LEU   A 1 67  ? -12.91780 5.28042   -18.29886 1.000 21.00681 ? 67  LEU   A C   1 
ATOM   522  O O   . LEU   A 1 67  ? -13.04391 4.06999   -18.19152 1.000 20.84035 ? 67  LEU   A O   1 
ATOM   523  C CB  . LEU   A 1 67  ? -13.09946 5.42817   -20.84205 1.000 30.22140 ? 67  LEU   A CB  1 
ATOM   524  C CG  . LEU   A 1 67  ? -13.19323 6.10559   -22.21647 1.000 34.98893 ? 67  LEU   A CG  1 
ATOM   525  C CD1 . LEU   A 1 67  ? -13.92135 7.39477   -22.22271 1.000 37.48488 ? 67  LEU   A CD1 1 
ATOM   526  C CD2 . LEU   A 1 67  ? -11.71586 6.65421   -22.47500 1.000 35.80773 ? 67  LEU   A CD2 1 
ATOM   527  N N   . VAL   A 1 68  ? -13.17988 6.14279   -17.30940 1.000 24.26553 ? 68  VAL   A N   1 
ATOM   528  C CA  . VAL   A 1 68  ? -13.75003 5.74117   -16.02530 1.000 22.22375 ? 68  VAL   A CA  1 
ATOM   529  C C   . VAL   A 1 68  ? -15.15677 6.31650   -15.89536 1.000 24.69878 ? 68  VAL   A C   1 
ATOM   530  O O   . VAL   A 1 68  ? -15.35384 7.52885   -16.01514 1.000 22.02903 ? 68  VAL   A O   1 
ATOM   531  C CB  . VAL   A 1 68  ? -12.84810 6.17614   -14.85700 1.000 24.61297 ? 68  VAL   A CB  1 
ATOM   532  C CG1 . VAL   A 1 68  ? -13.43835 5.72698   -13.54142 1.000 23.29639 ? 68  VAL   A CG1 1 
ATOM   533  C CG2 . VAL   A 1 68  ? -11.44579 5.55755   -15.04273 1.000 22.92880 ? 68  VAL   A CG2 1 
ATOM   534  N N   . GLN   A 1 69  ? -16.12306 5.44619   -15.62280 1.000 20.00489 ? 69  GLN   A N   1 
ATOM   535  C CA  . GLN   A 1 69  ? -17.54759 5.76642   -15.63516 1.000 27.31250 ? 69  GLN   A CA  1 
ATOM   536  C C   . GLN   A 1 69  ? -18.04893 5.50300   -14.22393 1.000 26.98005 ? 69  GLN   A C   1 
ATOM   537  O O   . GLN   A 1 69  ? -18.04279 4.34737   -13.78663 1.000 20.08681 ? 69  GLN   A O   1 
ATOM   538  C CB  . GLN   A 1 69  ? -18.28026 4.83904   -16.59744 1.000 33.46442 ? 69  GLN   A CB  1 
ATOM   539  C CG  . GLN   A 1 69  ? -17.66383 4.66160   -17.95326 1.000 35.72719 ? 69  GLN   A CG  1 
ATOM   540  C CD  . GLN   A 1 69  ? -18.33445 5.50242   -18.97831 1.000 44.74244 ? 69  GLN   A CD  1 
ATOM   541  O OE1 . GLN   A 1 69  ? -19.50408 5.87411   -18.81560 1.000 46.24184 ? 69  GLN   A OE1 1 
ATOM   542  N NE2 . GLN   A 1 69  ? -17.61556 5.81410   -20.05472 1.000 44.51298 ? 69  GLN   A NE2 1 
ATOM   543  N N   . ALA   A 1 70  ? -18.46943 6.54195   -13.50446 1.000 22.85721 ? 70  ALA   A N   1 
ATOM   544  C CA  . ALA   A 1 70  ? -19.04143 6.38711   -12.16410 1.000 27.93032 ? 70  ALA   A CA  1 
ATOM   545  C C   . ALA   A 1 70  ? -20.55035 6.59416   -12.29783 1.000 35.27191 ? 70  ALA   A C   1 
ATOM   546  O O   . ALA   A 1 70  ? -21.05648 7.71157   -12.18420 1.000 31.75217 ? 70  ALA   A O   1 
ATOM   547  C CB  . ALA   A 1 70  ? -18.42158 7.35937   -11.16989 1.000 26.14403 ? 70  ALA   A CB  1 
ATOM   548  N N   . GLY   A 1 71  ? -21.26528 5.49812   -12.52765 1.000 36.01777 ? 71  GLY   A N   1 
ATOM   549  C CA  . GLY   A 1 71  ? -22.65639 5.59928   -12.90400 1.000 43.92269 ? 71  GLY   A CA  1 
ATOM   550  C C   . GLY   A 1 71  ? -22.73774 6.27691   -14.25118 1.000 45.47623 ? 71  GLY   A C   1 
ATOM   551  O O   . GLY   A 1 71  ? -22.12808 5.80679   -15.21655 1.000 46.48025 ? 71  GLY   A O   1 
ATOM   552  N N   . ASN   A 1 72  ? -23.45267 7.40068   -14.32396 1.000 51.29809 ? 72  ASN   A N   1 
ATOM   553  C CA  . ASN   A 1 72  ? -23.57812 8.16826   -15.55845 1.000 59.74813 ? 72  ASN   A CA  1 
ATOM   554  C C   . ASN   A 1 72  ? -22.77708 9.46856   -15.50628 1.000 55.53725 ? 72  ASN   A C   1 
ATOM   555  O O   . ASN   A 1 72  ? -23.16137 10.46883  -16.11720 1.000 61.19473 ? 72  ASN   A O   1 
ATOM   556  C CB  . ASN   A 1 72  ? -25.04858 8.44616   -15.88163 1.000 64.65035 ? 72  ASN   A CB  1 
ATOM   557  C CG  . ASN   A 1 72  ? -25.82601 8.98806   -14.69097 1.000 66.60624 ? 72  ASN   A CG  1 
ATOM   558  O OD1 . ASN   A 1 72  ? -25.24762 9.56906   -13.77023 1.000 69.27751 ? 72  ASN   A OD1 1 
ATOM   559  N ND2 . ASN   A 1 72  ? -27.14554 8.80818   -14.71024 1.000 67.31339 ? 72  ASN   A ND2 1 
ATOM   560  N N   . VAL   A 1 73  ? -21.65160 9.44240   -14.79053 1.000 44.20758 ? 73  VAL   A N   1 
ATOM   561  C CA  . VAL   A 1 73  ? -20.65382 10.51629  -14.73018 1.000 44.43451 ? 73  VAL   A CA  1 
ATOM   562  C C   . VAL   A 1 73  ? -19.23047 9.87200   -14.89197 1.000 40.15683 ? 73  VAL   A C   1 
ATOM   563  O O   . VAL   A 1 73  ? -18.83588 9.13193   -13.98539 1.000 37.32360 ? 73  VAL   A O   1 
ATOM   564  C CB  . VAL   A 1 73  ? -20.78566 11.24636  -13.35237 1.000 45.04476 ? 73  VAL   A CB  1 
ATOM   565  C CG1 . VAL   A 1 73  ? -19.93817 12.47606  -13.20351 1.000 46.36581 ? 73  VAL   A CG1 1 
ATOM   566  C CG2 . VAL   A 1 73  ? -22.27621 11.55834  -12.90978 1.000 53.58369 ? 73  VAL   A CG2 1 
ATOM   567  N N   . GLN   A 1 74  ? -18.52162 9.99919   -16.11579 1.000 45.65140 ? 74  GLN   A N   1 
ATOM   568  C CA  . GLN   A 1 74  ? -17.22054 10.77949  -16.27310 1.000 43.31405 ? 74  GLN   A CA  1 
ATOM   569  C C   . GLN   A 1 74  ? -16.46162 11.38309  -15.13560 1.000 38.79153 ? 74  GLN   A C   1 
ATOM   570  O O   . GLN   A 1 74  ? -16.58005 12.49965  -14.61984 1.000 45.33435 ? 74  GLN   A O   1 
ATOM   571  C CB  . GLN   A 1 74  ? -17.03507 11.36205  -17.72841 1.000 45.27201 ? 74  GLN   A CB  1 
ATOM   572  C CG  . GLN   A 1 74  ? -16.25178 9.94788   -18.20921 1.000 45.91072 ? 74  GLN   A CG  1 
ATOM   573  C CD  . GLN   A 1 74  ? -15.90424 9.51281   -19.72448 1.000 52.95066 ? 74  GLN   A CD  1 
ATOM   574  O OE1 . GLN   A 1 74  ? -15.65622 9.20258   -20.80928 1.000 58.60801 ? 74  GLN   A OE1 1 
ATOM   575  N NE2 . GLN   A 1 74  ? -16.20558 10.78569  -19.71481 1.000 54.30746 ? 74  GLN   A NE2 1 
ATOM   576  N N   . LEU   A 1 75  ? -15.48239 10.48171  -14.87145 1.000 34.96442 ? 75  LEU   A N   1 
ATOM   577  C CA  . LEU   A 1 75  ? -14.26559 10.71774  -14.09992 1.000 32.61521 ? 75  LEU   A CA  1 
ATOM   578  C C   . LEU   A 1 75  ? -13.05852 10.96091  -15.00819 1.000 34.26391 ? 75  LEU   A C   1 
ATOM   579  O O   . LEU   A 1 75  ? -12.71777 10.13628  -15.86657 1.000 36.70249 ? 75  LEU   A O   1 
ATOM   580  C CB  . LEU   A 1 75  ? -13.91342 9.59351   -13.10632 1.000 30.07632 ? 75  LEU   A CB  1 
ATOM   581  C CG  . LEU   A 1 75  ? -14.92002 9.23192   -12.00277 1.000 31.25600 ? 75  LEU   A CG  1 
ATOM   582  C CD1 . LEU   A 1 75  ? -14.31990 8.30939   -10.91528 1.000 30.78006 ? 75  LEU   A CD1 1 
ATOM   583  C CD2 . LEU   A 1 75  ? -15.60729 10.43001  -11.38096 1.000 31.63356 ? 75  LEU   A CD2 1 
ATOM   584  N N   . ARG   A 1 76  ? -12.38733 12.08042  -14.79032 1.000 27.10663 ? 76  ARG   A N   1 
ATOM   585  C CA  . ARG   A 1 76  ? -11.19554 12.38718  -15.56635 1.000 30.26539 ? 76  ARG   A CA  1 
ATOM   586  C C   . ARG   A 1 76  ? -9.98558  11.70947  -14.92065 1.000 24.78487 ? 76  ARG   A C   1 
ATOM   587  O O   . ARG   A 1 76  ? -9.66501  11.99968  -13.76706 1.000 26.62950 ? 76  ARG   A O   1 
ATOM   588  C CB  . ARG   A 1 76  ? -11.00175 13.90381  -15.63629 1.000 34.74159 ? 76  ARG   A CB  1 
ATOM   589  C CG  . ARG   A 1 76  ? -9.78275  14.34687  -16.41859 1.000 35.20219 ? 76  ARG   A CG  1 
ATOM   590  C CD  . ARG   A 1 76  ? -9.58968  15.86621  -16.34894 1.000 40.59617 ? 76  ARG   A CD  1 
ATOM   591  N NE  . ARG   A 1 76  ? -8.18413  16.20013  -16.56046 1.000 49.51751 ? 76  ARG   A NE  1 
ATOM   592  C CZ  . ARG   A 1 76  ? -7.51834  17.13081  -15.87833 1.000 48.57561 ? 76  ARG   A CZ  1 
ATOM   593  N NH1 . ARG   A 1 76  ? -8.13858  17.83109  -14.93631 1.000 50.88437 ? 76  ARG   A NH1 1 
ATOM   594  N NH2 . ARG   A 1 76  ? -6.22838  17.34797  -16.12775 1.000 43.58377 ? 76  ARG   A NH2 1 
ATOM   595  N N   . VAL   A 1 77  ? -9.32103  10.80790  -15.65095 1.000 25.17963 ? 77  VAL   A N   1 
ATOM   596  C CA  . VAL   A 1 77  ? -8.06773  10.21689  -15.17138 1.000 25.08171 ? 77  VAL   A CA  1 
ATOM   597  C C   . VAL   A 1 77  ? -6.93563  11.22676  -15.29090 1.000 26.54336 ? 77  VAL   A C   1 
ATOM   598  O O   . VAL   A 1 77  ? -6.68104  11.75521  -16.37899 1.000 26.22175 ? 77  VAL   A O   1 
ATOM   599  C CB  . VAL   A 1 77  ? -7.74061  8.93948   -15.95645 1.000 21.47292 ? 77  VAL   A CB  1 
ATOM   600  C CG1 . VAL   A 1 77  ? -6.34901  8.41125   -15.58973 1.000 22.84994 ? 77  VAL   A CG1 1 
ATOM   601  C CG2 . VAL   A 1 77  ? -8.79686  7.87448   -15.65389 1.000 24.46335 ? 77  VAL   A CG2 1 
ATOM   602  N N   . ILE   A 1 78  ? -6.23627  11.48334  -14.18018 1.000 25.09960 ? 78  ILE   A N   1 
ATOM   603  C CA  . ILE   A 1 78  ? -5.13436  12.44841  -14.14275 1.000 24.09804 ? 78  ILE   A CA  1 
ATOM   604  C C   . ILE   A 1 78  ? -3.78621  11.79924  -13.84012 1.000 26.62001 ? 78  ILE   A C   1 
ATOM   605  O O   . ILE   A 1 78  ? -2.77063  12.51000  -13.74403 1.000 24.89770 ? 78  ILE   A O   1 
ATOM   606  C CB  . ILE   A 1 78  ? -5.41760  13.58969  -13.14690 1.000 25.31445 ? 78  ILE   A CB  1 
ATOM   607  C CG1 . ILE   A 1 78  ? -5.56863  13.04494  -11.72034 1.000 28.22675 ? 78  ILE   A CG1 1 
ATOM   608  C CG2 . ILE   A 1 78  ? -6.65746  14.41023  -13.58279 1.000 29.67975 ? 78  ILE   A CG2 1 
ATOM   609  C CD1 . ILE   A 1 78  ? -5.69497  14.11666  -10.63250 1.000 28.87728 ? 78  ILE   A CD1 1 
ATOM   610  N N   . GLY   A 1 79  ? -3.73758  10.47900  -13.69534 1.000 24.96749 ? 79  GLY   A N   1 
ATOM   611  C CA  . GLY   A 1 79  ? -2.49753  9.77791   -13.43364 1.000 22.06076 ? 79  GLY   A CA  1 
ATOM   612  C C   . GLY   A 1 79  ? -2.73252  8.28869   -13.49947 1.000 25.06558 ? 79  GLY   A C   1 
ATOM   613  O O   . GLY   A 1 79  ? -3.85894  7.83029   -13.28759 1.000 24.66082 ? 79  GLY   A O   1 
ATOM   614  N N   . HIS   A 1 80  ? -1.69630  7.51518   -13.80500 1.000 22.43655 ? 80  HIS   A N   1 
ATOM   615  C CA  . HIS   A 1 80  ? -1.85210  6.07116   -13.82197 1.000 20.88667 ? 80  HIS   A CA  1 
ATOM   616  C C   . HIS   A 1 80  ? -0.53358  5.41814   -13.43275 1.000 25.51765 ? 80  HIS   A C   1 
ATOM   617  O O   . HIS   A 1 80  ? 0.53641   5.92453   -13.78455 1.000 22.31305 ? 80  HIS   A O   1 
ATOM   618  C CB  . HIS   A 1 80  ? -2.28747  5.61710   -15.19951 1.000 19.59160 ? 80  HIS   A CB  1 
ATOM   619  C CG  . HIS   A 1 80  ? -1.27766  5.90025   -16.26410 1.000 22.45415 ? 80  HIS   A CG  1 
ATOM   620  N ND1 . HIS   A 1 80  ? -1.12356  7.14522   -16.83494 1.000 25.88021 ? 80  HIS   A ND1 1 
ATOM   621  C CD2 . HIS   A 1 80  ? -0.36751  5.09518   -16.86031 1.000 23.01386 ? 80  HIS   A CD2 1 
ATOM   622  C CE1 . HIS   A 1 80  ? -0.17221  7.08851   -17.75322 1.000 28.13132 ? 80  HIS   A CE1 1 
ATOM   623  N NE2 . HIS   A 1 80  ? 0.29017   5.85112   -17.79986 1.000 26.14179 ? 80  HIS   A NE2 1 
ATOM   624  N N   . SER   A 1 81  ? -0.60165  4.31648   -12.67910 1.000 18.65901 ? 81  SER   A N   1 
ATOM   625  C CA  . SER   A 1 81  ? 0.60530   3.55731   -12.36880 1.000 19.79715 ? 81  SER   A CA  1 
ATOM   626  C C   . SER   A 1 81  ? 0.24432   2.10032   -12.15729 1.000 21.89512 ? 81  SER   A C   1 
ATOM   627  O O   . SER   A 1 81  ? -0.91708  1.74040   -11.97326 1.000 17.23787 ? 81  SER   A O   1 
ATOM   628  C CB  . SER   A 1 81  ? 1.34154   4.07515   -11.12697 1.000 20.21728 ? 81  SER   A CB  1 
ATOM   629  O OG  . SER   A 1 81  ? 0.46033   4.17545   -10.03589 1.000 20.61771 ? 81  SER   A OG  1 
ATOM   630  N N   . MET   A 1 82  ? 1.24958   1.25307   -12.17529 1.000 14.59605 ? 82  MET   A N   1 
ATOM   631  C CA  . MET   A 1 82  ? 0.98229   -0.13899  -11.92705 1.000 15.97211 ? 82  MET   A CA  1 
ATOM   632  C C   . MET   A 1 82  ? 1.49560   -0.49779  -10.54127 1.000 19.40676 ? 82  MET   A C   1 
ATOM   633  O O   . MET   A 1 82  ? 2.54962   -0.01777  -10.10919 1.000 18.08351 ? 82  MET   A O   1 
ATOM   634  C CB  . MET   A 1 82  ? 1.61121   -0.97042  -13.02426 1.000 20.08206 ? 82  MET   A CB  1 
ATOM   635  C CG  . MET   A 1 82  ? 1.23848   -2.34184  -12.96209 1.000 14.86475 ? 82  MET   A CG  1 
ATOM   636  S SD  . MET   A 1 82  ? 1.82699   -3.13964  -14.46194 1.000 22.03378 ? 82  MET   A SD  1 
ATOM   637  C CE  . MET   A 1 82  ? 3.34643   -2.24794  -14.87296 1.000 24.64126 ? 82  MET   A CE  1 
ATOM   638  N N   . GLN   A 1 83  ? 0.70781   -1.26406  -9.80538  1.000 15.36119 ? 83  GLN   A N   1 
ATOM   639  C CA  . GLN   A 1 83  ? 1.17014   -1.82223  -8.53851  1.000 17.04679 ? 83  GLN   A CA  1 
ATOM   640  C C   . GLN   A 1 83  ? 0.94120   -3.32343  -8.61842  1.000 18.40819 ? 83  GLN   A C   1 
ATOM   641  O O   . GLN   A 1 83  ? -0.20401  -3.77586  -8.53823  1.000 12.28568 ? 83  GLN   A O   1 
ATOM   642  C CB  . GLN   A 1 83  ? 0.45846   -1.20816  -7.33022  1.000 19.59973 ? 83  GLN   A CB  1 
ATOM   643  C CG  . GLN   A 1 83  ? 0.81056   -1.99169  -6.04589  1.000 24.84955 ? 83  GLN   A CG  1 
ATOM   644  C CD  . GLN   A 1 83  ? 0.93603   -1.13936  -4.78849  1.000 34.85027 ? 83  GLN   A CD  1 
ATOM   645  O OE1 . GLN   A 1 83  ? 0.58402   0.04641   -4.78738  1.000 33.50539 ? 83  GLN   A OE1 1 
ATOM   646  N NE2 . GLN   A 1 83  ? 1.51831   -1.72915  -3.71922  1.000 37.47340 ? 83  GLN   A NE2 1 
ATOM   647  N N   . ASN   A 1 84  ? 2.02429   -4.08541  -8.80919  1.000 12.54872 ? 84  ASN   A N   1 
ATOM   648  C CA  . ASN   A 1 84  ? 1.92768   -5.52315  -9.04864  1.000 13.72205 ? 84  ASN   A CA  1 
ATOM   649  C C   . ASN   A 1 84  ? 0.91960   -5.79704  -10.17000 1.000 13.63529 ? 84  ASN   A C   1 
ATOM   650  O O   . ASN   A 1 84  ? 1.08842   -5.26784  -11.27759 1.000 11.74027 ? 84  ASN   A O   1 
ATOM   651  C CB  . ASN   A 1 84  ? 1.63164   -6.20695  -7.70991  1.000 9.97321  ? 84  ASN   A CB  1 
ATOM   652  C CG  . ASN   A 1 84  ? 2.68830   -5.82140  -6.67235  1.000 14.21256 ? 84  ASN   A CG  1 
ATOM   653  O OD1 . ASN   A 1 84  ? 3.88426   -5.98774  -6.94912  1.000 13.10647 ? 84  ASN   A OD1 1 
ATOM   654  N ND2 . ASN   A 1 84  ? 2.27605   -5.18145  -5.56093  1.000 12.73076 ? 84  ASN   A ND2 1 
ATOM   655  N N   . CYS   A 1 85  ? -0.13244  -6.57434  -9.92307  1.000 12.28159 ? 85  CYS   A N   1 
ATOM   656  C CA  . CYS   A 1 85  ? -1.10556  -6.88904  -10.96254 1.000 10.12668 ? 85  CYS   A CA  1 
ATOM   657  C C   . CYS   A 1 85  ? -2.34571  -5.96996  -10.96572 1.000 13.06826 ? 85  CYS   A C   1 
ATOM   658  O O   . CYS   A 1 85  ? -3.32065  -6.26495  -11.67021 1.000 10.14911 ? 85  CYS   A O   1 
ATOM   659  C CB  . CYS   A 1 85  ? -1.53530  -8.33985  -10.82352 1.000 13.19359 ? 85  CYS   A CB  1 
ATOM   660  S SG  . CYS   A 1 85  ? -0.14621  -9.45875  -11.11451 1.000 11.20373 ? 85  CYS   A SG  1 
ATOM   661  N N   . VAL   A 1 86  ? -2.35532  -4.88007  -10.21016 1.000 8.95597  ? 86  VAL   A N   1 
ATOM   662  C CA  . VAL   A 1 86  ? -3.44563  -3.92588  -10.34935 1.000 11.59638 ? 86  VAL   A CA  1 
ATOM   663  C C   . VAL   A 1 86  ? -2.89939  -2.64538  -10.95688 1.000 14.44290 ? 86  VAL   A C   1 
ATOM   664  O O   . VAL   A 1 86  ? -1.69432  -2.35113  -10.91072 1.000 9.82657  ? 86  VAL   A O   1 
ATOM   665  C CB  . VAL   A 1 86  ? -4.19754  -3.61477  -9.02889  1.000 14.70970 ? 86  VAL   A CB  1 
ATOM   666  C CG1 . VAL   A 1 86  ? -4.79946  -4.91597  -8.42929  1.000 14.45477 ? 86  VAL   A CG1 1 
ATOM   667  C CG2 . VAL   A 1 86  ? -3.29052  -2.96509  -8.08304  1.000 16.99942 ? 86  VAL   A CG2 1 
ATOM   668  N N   . LEU   A 1 87  ? -3.81224  -1.89770  -11.55929 1.000 11.66101 ? 87  LEU   A N   1 
ATOM   669  C CA  . LEU   A 1 87  ? -3.58401  -0.52296  -11.97804 1.000 12.94201 ? 87  LEU   A CA  1 
ATOM   670  C C   . LEU   A 1 87  ? -4.18524  0.41317   -10.95310 1.000 14.35923 ? 87  LEU   A C   1 
ATOM   671  O O   . LEU   A 1 87  ? -5.23634  0.12136   -10.38394 1.000 13.57081 ? 87  LEU   A O   1 
ATOM   672  C CB  . LEU   A 1 87  ? -4.24707  -0.22828  -13.30875 1.000 17.35700 ? 87  LEU   A CB  1 
ATOM   673  C CG  . LEU   A 1 87  ? -3.74984  -0.69406  -14.63963 1.000 17.14691 ? 87  LEU   A CG  1 
ATOM   674  C CD1 . LEU   A 1 87  ? -4.57367  0.06196   -15.69214 1.000 17.26718 ? 87  LEU   A CD1 1 
ATOM   675  C CD2 . LEU   A 1 87  ? -2.24537  -0.42807  -14.73698 1.000 20.79162 ? 87  LEU   A CD2 1 
ATOM   676  N N   . LYS   A 1 88  ? -3.52038  1.53974   -10.73024 1.000 16.28838 ? 88  LYS   A N   1 
ATOM   677  C CA  . LYS   A 1 88  ? -4.04945  2.61124   -9.90227  1.000 16.78565 ? 88  LYS   A CA  1 
ATOM   678  C C   . LYS   A 1 88  ? -4.25591  3.80860   -10.82058 1.000 17.07063 ? 88  LYS   A C   1 
ATOM   679  O O   . LYS   A 1 88  ? -3.28437  4.35595   -11.36887 1.000 18.67709 ? 88  LYS   A O   1 
ATOM   680  C CB  . LYS   A 1 88  ? -3.09856  2.92354   -8.75431  1.000 16.55308 ? 88  LYS   A CB  1 
ATOM   681  C CG  . LYS   A 1 88  ? -2.89659  1.73065   -7.80731  1.000 18.85661 ? 88  LYS   A CG  1 
ATOM   682  C CD  . LYS   A 1 88  ? -1.79506  2.00608   -6.78926  1.000 19.14231 ? 88  LYS   A CD  1 
ATOM   683  C CE  . LYS   A 1 88  ? -2.31152  2.86587   -5.65244  1.000 21.29902 ? 88  LYS   A CE  1 
ATOM   684  N NZ  . LYS   A 1 88  ? -1.28314  3.09326   -4.55488  1.000 30.03482 ? 88  LYS   A NZ  1 
ATOM   685  N N   . LEU   A 1 89  ? -5.51428  4.18921   -11.00283 1.000 16.04410 ? 89  LEU   A N   1 
ATOM   686  C CA  . LEU   A 1 89  ? -5.89740  5.27743   -11.89246 1.000 16.88029 ? 89  LEU   A CA  1 
ATOM   687  C C   . LEU   A 1 89  ? -6.20725  6.48108   -11.01645 1.000 21.26971 ? 89  LEU   A C   1 
ATOM   688  O O   . LEU   A 1 89  ? -7.20586  6.49130   -10.28961 1.000 15.66911 ? 89  LEU   A O   1 
ATOM   689  C CB  . LEU   A 1 89  ? -7.09586  4.87237   -12.74264 1.000 18.16541 ? 89  LEU   A CB  1 
ATOM   690  C CG  . LEU   A 1 89  ? -6.76374  3.69814   -13.66332 1.000 15.47057 ? 89  LEU   A CG  1 
ATOM   691  C CD1 . LEU   A 1 89  ? -7.90354  3.43133   -14.56784 1.000 19.16078 ? 89  LEU   A CD1 1 
ATOM   692  C CD2 . LEU   A 1 89  ? -5.51702  3.96747   -14.50140 1.000 17.54897 ? 89  LEU   A CD2 1 
ATOM   693  N N   . LYS   A 1 90  ? -5.32338  7.46617   -11.03305 1.000 19.39439 ? 90  LYS   A N   1 
ATOM   694  C CA  . LYS   A 1 90  ? -5.56306  8.68219   -10.27124 1.000 21.36638 ? 90  LYS   A CA  1 
ATOM   695  C C   . LYS   A 1 90  ? -6.65429  9.49624   -10.97248 1.000 19.59706 ? 90  LYS   A C   1 
ATOM   696  O O   . LYS   A 1 90  ? -6.54425  9.77210   -12.16886 1.000 25.26911 ? 90  LYS   A O   1 
ATOM   697  C CB  . LYS   A 1 90  ? -4.24866  9.45187   -10.19600 1.000 26.88975 ? 90  LYS   A CB  1 
ATOM   698  C CG  . LYS   A 1 90  ? -4.18371  10.73300  -9.42389  1.000 30.26814 ? 90  LYS   A CG  1 
ATOM   699  C CD  . LYS   A 1 90  ? -4.23024  10.59158  -7.95320  1.000 32.98136 ? 90  LYS   A CD  1 
ATOM   700  C CE  . LYS   A 1 90  ? -4.04401  11.98433  -7.39568  1.000 35.05819 ? 90  LYS   A CE  1 
ATOM   701  N NZ  . LYS   A 1 90  ? -2.69411  12.48391  -7.75453  1.000 36.90279 ? 90  LYS   A NZ  1 
ATOM   702  N N   . VAL   A 1 91  ? -7.72970  9.85559   -10.26608 1.000 19.55087 ? 91  VAL   A N   1 
ATOM   703  C CA  . VAL   A 1 91  ? -8.80781  10.60912  -10.90826 1.000 24.06659 ? 91  VAL   A CA  1 
ATOM   704  C C   . VAL   A 1 91  ? -8.98319  11.96304  -10.22317 1.000 23.57927 ? 91  VAL   A C   1 
ATOM   705  O O   . VAL   A 1 91  ? -8.50452  12.19068  -9.11306  1.000 26.85974 ? 91  VAL   A O   1 
ATOM   706  C CB  . VAL   A 1 91  ? -10.14095 9.82278   -10.95365 1.000 25.60248 ? 91  VAL   A CB  1 
ATOM   707  C CG1 . VAL   A 1 91  ? -9.96571  8.50003   -11.74844 1.000 23.56546 ? 91  VAL   A CG1 1 
ATOM   708  C CG2 . VAL   A 1 91  ? -10.65791 9.55643   -9.54696  1.000 21.95484 ? 91  VAL   A CG2 1 
ATOM   709  N N   . ASP   A 1 92  ? -9.65739  12.89028  -10.91322 1.000 27.40239 ? 92  ASP   A N   1 
ATOM   710  C CA  . ASP   A 1 92  ? -9.70198  14.25962  -10.39111 1.000 31.04509 ? 92  ASP   A CA  1 
ATOM   711  C C   . ASP   A 1 92  ? -10.80279 14.46505  -9.35555  1.000 30.81716 ? 92  ASP   A C   1 
ATOM   712  O O   . ASP   A 1 92  ? -11.06478 15.60713  -8.96236  1.000 32.26072 ? 92  ASP   A O   1 
ATOM   713  C CB  . ASP   A 1 92  ? -9.86801  15.28281  -11.53434 1.000 31.45722 ? 92  ASP   A CB  1 
ATOM   714  C CG  . ASP   A 1 92  ? -11.22432 15.18781  -12.22270 1.000 35.03319 ? 92  ASP   A CG  1 
ATOM   715  O OD1 . ASP   A 1 92  ? -11.46856 15.93707  -13.19563 1.000 37.72254 ? 92  ASP   A OD1 1 
ATOM   716  O OD2 . ASP   A 1 92  ? -12.06167 14.37360  -11.77419 1.000 40.08764 ? 92  ASP   A OD2 1 
ATOM   717  N N   . THR   A 1 93  ? -11.47150 13.40488  -8.91799  1.000 27.43630 ? 93  THR   A N   1 
ATOM   718  C CA  . THR   A 1 93  ? -12.50628 13.52802  -7.90196  1.000 26.77774 ? 93  THR   A CA  1 
ATOM   719  C C   . THR   A 1 93  ? -12.32810 12.43826  -6.85225  1.000 24.23254 ? 93  THR   A C   1 
ATOM   720  O O   . THR   A 1 93  ? -12.20878 11.26439  -7.20141  1.000 23.95102 ? 93  THR   A O   1 
ATOM   721  C CB  . THR   A 1 93  ? -13.89397 13.41900  -8.53769  1.000 28.28546 ? 93  THR   A CB  1 
ATOM   722  O OG1 . THR   A 1 93  ? -13.99070 14.33057  -9.64059  1.000 31.23896 ? 93  THR   A OG1 1 
ATOM   723  C CG2 . THR   A 1 93  ? -14.98051 13.72621  -7.50743  1.000 26.12300 ? 93  THR   A CG2 1 
ATOM   724  N N   . ALA   A 1 94  ? -12.33643 12.81825  -5.57542  1.000 20.47672 ? 94  ALA   A N   1 
ATOM   725  C CA  . ALA   A 1 94  ? -12.43148 11.83658  -4.50203  1.000 20.26211 ? 94  ALA   A CA  1 
ATOM   726  C C   . ALA   A 1 94  ? -13.84682 11.25389  -4.40120  1.000 21.65981 ? 94  ALA   A C   1 
ATOM   727  O O   . ALA   A 1 94  ? -14.84264 11.97202  -4.46245  1.000 19.88276 ? 94  ALA   A O   1 
ATOM   728  C CB  . ALA   A 1 94  ? -12.03545 12.47790  -3.17495  1.000 20.33502 ? 94  ALA   A CB  1 
ATOM   729  N N   . ASN   A 1 95  ? -13.93754 9.94772   -4.24723  1.000 23.25240 ? 95  ASN   A N   1 
ATOM   730  C CA  . ASN   A 1 95  ? -15.25853 9.33779   -4.09445  1.000 20.40729 ? 95  ASN   A CA  1 
ATOM   731  C C   . ASN   A 1 95  ? -15.91700 9.83511   -2.81057  1.000 20.98297 ? 95  ASN   A C   1 
ATOM   732  O O   . ASN   A 1 95  ? -15.44981 9.50356   -1.71377  1.000 20.85242 ? 95  ASN   A O   1 
ATOM   733  C CB  . ASN   A 1 95  ? -15.12152 7.81307   -4.09191  1.000 16.78362 ? 95  ASN   A CB  1 
ATOM   734  C CG  . ASN   A 1 95  ? -16.47416 7.08182   -4.08666  1.000 20.02640 ? 95  ASN   A CG  1 
ATOM   735  O OD1 . ASN   A 1 95  ? -17.54039 7.71678   -4.06307  1.000 17.90055 ? 95  ASN   A OD1 1 
ATOM   736  N ND2 . ASN   A 1 95  ? -16.42825 5.73149   -4.15250  1.000 14.31274 ? 95  ASN   A ND2 1 
ATOM   737  N N   . PRO   A 1 96  ? -17.01387 10.60663  -2.89602  1.000 23.66610 ? 96  PRO   A N   1 
ATOM   738  C CA  . PRO   A 1 96  ? -17.66815 11.07234  -1.66140  1.000 21.42287 ? 96  PRO   A CA  1 
ATOM   739  C C   . PRO   A 1 96  ? -18.26136 9.93532   -0.86483  1.000 22.69839 ? 96  PRO   A C   1 
ATOM   740  O O   . PRO   A 1 96  ? -18.55427 10.10287  0.32427   1.000 22.20584 ? 96  PRO   A O   1 
ATOM   741  C CB  . PRO   A 1 96  ? -18.76183 12.02620  -2.16932  1.000 23.74827 ? 96  PRO   A CB  1 
ATOM   742  C CG  . PRO   A 1 96  ? -19.06971 11.54978  -3.59009  1.000 24.05323 ? 96  PRO   A CG  1 
ATOM   743  C CD  . PRO   A 1 96  ? -17.77542 10.95350  -4.11799  1.000 21.11487 ? 96  PRO   A CD  1 
ATOM   744  N N   . LYS   A 1 97  ? -18.45638 8.78045   -1.48156  1.000 22.28461 ? 97  LYS   A N   1 
ATOM   745  C CA  . LYS   A 1 97  ? -19.00093 7.64424   -0.76307  1.000 23.44418 ? 97  LYS   A CA  1 
ATOM   746  C C   . LYS   A 1 97  ? -17.91416 6.73050   -0.19780  1.000 21.67110 ? 97  LYS   A C   1 
ATOM   747  O O   . LYS   A 1 97  ? -18.22845 5.61856   0.24854   1.000 17.18205 ? 97  LYS   A O   1 
ATOM   748  C CB  . LYS   A 1 97  ? -19.95332 6.88180   -1.67843  1.000 21.47117 ? 97  LYS   A CB  1 
ATOM   749  C CG  . LYS   A 1 97  ? -21.26308 7.65926   -1.89163  1.000 22.61666 ? 97  LYS   A CG  1 
ATOM   750  C CD  . LYS   A 1 97  ? -22.19333 6.92337   -2.84018  1.000 27.48665 ? 97  LYS   A CD  1 
ATOM   751  C CE  . LYS   A 1 97  ? -22.49918 7.70074   -4.11086  1.000 29.34585 ? 97  LYS   A CE  1 
ATOM   752  N NZ  . LYS   A 1 97  ? -23.68524 7.08808   -4.76023  1.000 32.64048 ? 97  LYS   A NZ  1 
ATOM   753  N N   . THR   A 1 98  ? -16.66350 7.18818   -0.16108  1.000 18.61652 ? 98  THR   A N   1 
ATOM   754  C CA  . THR   A 1 98  ? -15.57009 6.34941   0.34111   1.000 20.16881 ? 98  THR   A CA  1 
ATOM   755  C C   . THR   A 1 98  ? -15.83782 5.93538   1.78134   1.000 21.10861 ? 98  THR   A C   1 
ATOM   756  O O   . THR   A 1 98  ? -15.90410 6.80382   2.66028   1.000 17.01717 ? 98  THR   A O   1 
ATOM   757  C CB  . THR   A 1 98  ? -14.22986 7.09045   0.25684   1.000 16.63214 ? 98  THR   A CB  1 
ATOM   758  O OG1 . THR   A 1 98  ? -13.98821 7.45909   -1.09692  1.000 17.57341 ? 98  THR   A OG1 1 
ATOM   759  C CG2 . THR   A 1 98  ? -13.06520 6.20333   0.72101   1.000 16.22863 ? 98  THR   A CG2 1 
ATOM   760  N N   . PRO   A 1 99  ? -15.99384 4.64562   2.07303   1.000 21.82706 ? 99  PRO   A N   1 
ATOM   761  C CA  . PRO   A 1 99  ? -16.12670 4.21735   3.46515   1.000 16.36929 ? 99  PRO   A CA  1 
ATOM   762  C C   . PRO   A 1 99  ? -14.76696 4.20536   4.14306   1.000 17.60632 ? 99  PRO   A C   1 
ATOM   763  O O   . PRO   A 1 99  ? -13.72619 4.24608   3.50002   1.000 16.88640 ? 99  PRO   A O   1 
ATOM   764  C CB  . PRO   A 1 99  ? -16.64923 2.79212   3.34208   1.000 16.39402 ? 99  PRO   A CB  1 
ATOM   765  C CG  . PRO   A 1 99  ? -15.95307 2.29698   2.14214   1.000 13.12517 ? 99  PRO   A CG  1 
ATOM   766  C CD  . PRO   A 1 99  ? -15.77922 3.48665   1.18833   1.000 18.08639 ? 99  PRO   A CD  1 
ATOM   767  N N   . LYS   A 1 100 ? -14.78976 4.09281   5.46608   1.000 17.19307 ? 100 LYS   A N   1 
ATOM   768  C CA  . LYS   A 1 100 ? -13.56428 3.72525   6.16213   1.000 17.76939 ? 100 LYS   A CA  1 
ATOM   769  C C   . LYS   A 1 100 ? -13.15100 2.33387   5.66775   1.000 18.68693 ? 100 LYS   A C   1 
ATOM   770  O O   . LYS   A 1 100 ? -13.99319 1.44666   5.53449   1.000 14.86080 ? 100 LYS   A O   1 
ATOM   771  C CB  . LYS   A 1 100 ? -13.80987 3.76782   7.67217   1.000 22.07041 ? 100 LYS   A CB  1 
ATOM   772  C CG  . LYS   A 1 100 ? -12.80029 3.03376   8.53869   1.000 26.21639 ? 100 LYS   A CG  1 
ATOM   773  C CD  . LYS   A 1 100 ? -11.55732 3.89060   8.92628   1.000 33.68332 ? 100 LYS   A CD  1 
ATOM   774  C CE  . LYS   A 1 100 ? -10.89152 3.40542   10.26553  1.000 31.94531 ? 100 LYS   A CE  1 
ATOM   775  N NZ  . LYS   A 1 100 ? -10.54645 1.91904   10.28823  1.000 34.36485 ? 100 LYS   A NZ  1 
ATOM   776  N N   . TYR   A 1 101 ? -11.87812 2.15024   5.30587   1.000 15.62252 ? 101 TYR   A N   1 
ATOM   777  C CA  . TYR   A 1 101 ? -11.51671 0.87545   4.68949   1.000 13.27098 ? 101 TYR   A CA  1 
ATOM   778  C C   . TYR   A 1 101 ? -10.09129 0.48831   5.06512   1.000 17.96074 ? 101 TYR   A C   1 
ATOM   779  O O   . TYR   A 1 101 ? -9.29953  1.31788   5.53921   1.000 14.01802 ? 101 TYR   A O   1 
ATOM   780  C CB  . TYR   A 1 101 ? -11.65946 0.90210   3.14786   1.000 11.43042 ? 101 TYR   A CB  1 
ATOM   781  C CG  . TYR   A 1 101 ? -10.63269 1.76682   2.41364   1.000 16.92095 ? 101 TYR   A CG  1 
ATOM   782  C CD1 . TYR   A 1 101 ? -10.88272 3.09907   2.17625   1.000 16.65565 ? 101 TYR   A CD1 1 
ATOM   783  C CD2 . TYR   A 1 101 ? -9.40091  1.24559   1.99104   1.000 16.56691 ? 101 TYR   A CD2 1 
ATOM   784  C CE1 . TYR   A 1 101 ? -9.98182  3.88529   1.51354   1.000 19.16385 ? 101 TYR   A CE1 1 
ATOM   785  C CE2 . TYR   A 1 101 ? -8.45300  2.06030   1.32258   1.000 17.49065 ? 101 TYR   A CE2 1 
ATOM   786  C CZ  . TYR   A 1 101 ? -8.76221  3.38380   1.10607   1.000 18.55192 ? 101 TYR   A CZ  1 
ATOM   787  O OH  . TYR   A 1 101 ? -7.88722  4.24104   0.46084   1.000 22.67291 ? 101 TYR   A OH  1 
ATOM   788  N N   . LYS   A 1 102 ? -9.77580  -0.79639  4.84135   1.000 12.39945 ? 102 LYS   A N   1 
ATOM   789  C CA  . LYS   A 1 102 ? -8.40972  -1.32454  4.89990   1.000 12.77357 ? 102 LYS   A CA  1 
ATOM   790  C C   . LYS   A 1 102 ? -8.19929  -2.26138  3.72123   1.000 13.42528 ? 102 LYS   A C   1 
ATOM   791  O O   . LYS   A 1 102 ? -9.14841  -2.86590  3.21695   1.000 9.73604  ? 102 LYS   A O   1 
ATOM   792  C CB  . LYS   A 1 102 ? -8.12388  -2.13399  6.17179   1.000 12.56222 ? 102 LYS   A CB  1 
ATOM   793  C CG  . LYS   A 1 102 ? -8.59109  -1.48913  7.41501   1.000 24.67763 ? 102 LYS   A CG  1 
ATOM   794  C CD  . LYS   A 1 102 ? -8.02645  -2.14616  8.66427   1.000 27.46857 ? 102 LYS   A CD  1 
ATOM   795  C CE  . LYS   A 1 102 ? -8.47146  -3.58207  8.74598   1.000 28.99556 ? 102 LYS   A CE  1 
ATOM   796  N NZ  . LYS   A 1 102 ? -8.64729  -4.03895  10.16441  1.000 38.24096 ? 102 LYS   A NZ  1 
ATOM   797  N N   . PHE   A 1 103 ? -6.93633  -2.45149  3.33796   1.000 11.18167 ? 103 PHE   A N   1 
ATOM   798  C CA  . PHE   A 1 103 ? -6.56386  -3.50299  2.40144   1.000 8.98360  ? 103 PHE   A CA  1 
ATOM   799  C C   . PHE   A 1 103 ? -5.90656  -4.61226  3.22053   1.000 13.50489 ? 103 PHE   A C   1 
ATOM   800  O O   . PHE   A 1 103 ? -4.83133  -4.39647  3.78925   1.000 10.95614 ? 103 PHE   A O   1 
ATOM   801  C CB  . PHE   A 1 103 ? -5.56019  -2.99673  1.35827   1.000 12.88007 ? 103 PHE   A CB  1 
ATOM   802  C CG  . PHE   A 1 103 ? -6.12010  -2.08534  0.31611   1.000 10.10362 ? 103 PHE   A CG  1 
ATOM   803  C CD1 . PHE   A 1 103 ? -7.50086  -1.90730  0.16196   1.000 10.01070 ? 103 PHE   A CD1 1 
ATOM   804  C CD2 . PHE   A 1 103 ? -5.24963  -1.40005  -0.53132  1.000 11.61234 ? 103 PHE   A CD2 1 
ATOM   805  C CE1 . PHE   A 1 103 ? -8.01985  -1.06224  -0.82038  1.000 10.58104 ? 103 PHE   A CE1 1 
ATOM   806  C CE2 . PHE   A 1 103 ? -5.74239  -0.56375  -1.52157  1.000 12.30442 ? 103 PHE   A CE2 1 
ATOM   807  C CZ  . PHE   A 1 103 ? -7.14885  -0.41395  -1.69128  1.000 11.95628 ? 103 PHE   A CZ  1 
ATOM   808  N N   . VAL   A 1 104 ? -6.52583  -5.79986  3.28140   1.000 7.56209  ? 104 VAL   A N   1 
ATOM   809  C CA  . VAL   A 1 104 ? -5.99093  -6.88166  4.10127   1.000 12.49339 ? 104 VAL   A CA  1 
ATOM   810  C C   . VAL   A 1 104 ? -5.84648  -8.06265  3.16426   1.000 12.01549 ? 104 VAL   A C   1 
ATOM   811  O O   . VAL   A 1 104 ? -6.55810  -8.15981  2.16112   1.000 19.20475 ? 104 VAL   A O   1 
ATOM   812  C CB  . VAL   A 1 104 ? -6.89983  -7.24281  5.29427   1.000 13.12314 ? 104 VAL   A CB  1 
ATOM   813  C CG1 . VAL   A 1 104 ? -7.20475  -5.98631  6.13889   1.000 17.12385 ? 104 VAL   A CG1 1 
ATOM   814  C CG2 . VAL   A 1 104 ? -8.18371  -7.81630  4.80869   1.000 15.24781 ? 104 VAL   A CG2 1 
ATOM   815  N N   . ARG   A 1 105 ? -4.93139  -8.97772  3.48769   1.000 8.62997  ? 105 ARG   A N   1 
ATOM   816  C CA  . ARG   A 1 105 ? -4.81107  -10.21933 2.73416   1.000 6.08501  ? 105 ARG   A CA  1 
ATOM   817  C C   . ARG   A 1 105 ? -5.26117  -11.33467 3.65629   1.000 8.68711  ? 105 ARG   A C   1 
ATOM   818  O O   . ARG   A 1 105 ? -4.84080  -11.37728 4.81174   1.000 8.91038  ? 105 ARG   A O   1 
ATOM   819  C CB  . ARG   A 1 105 ? -3.37922  -10.47658 2.27173   1.000 9.98519  ? 105 ARG   A CB  1 
ATOM   820  C CG  . ARG   A 1 105 ? -3.25579  -11.66565 1.31363   1.000 8.75900  ? 105 ARG   A CG  1 
ATOM   821  C CD  . ARG   A 1 105 ? -1.77959  -11.86428 0.99854   1.000 8.12051  ? 105 ARG   A CD  1 
ATOM   822  N NE  . ARG   A 1 105 ? -1.60548  -13.09434 0.25609   1.000 7.77358  ? 105 ARG   A NE  1 
ATOM   823  C CZ  . ARG   A 1 105 ? -1.57745  -13.14892 -1.05781  1.000 8.69248  ? 105 ARG   A CZ  1 
ATOM   824  N NH1 . ARG   A 1 105 ? -1.70417  -12.02074 -1.73637  1.000 7.86668  ? 105 ARG   A NH1 1 
ATOM   825  N NH2 . ARG   A 1 105 ? -1.39000  -14.30723 -1.69171  1.000 5.71360  ? 105 ARG   A NH2 1 
ATOM   826  N N   . ILE   A 1 106 ? -6.13453  -12.20612 3.17098   1.000 8.31451  ? 106 ILE   A N   1 
ATOM   827  C CA  . ILE   A 1 106 ? -6.67885  -13.26225 3.98446   1.000 11.14605 ? 106 ILE   A CA  1 
ATOM   828  C C   . ILE   A 1 106 ? -5.87940  -14.53347 3.75677   1.000 8.20205  ? 106 ILE   A C   1 
ATOM   829  O O   . ILE   A 1 106 ? -5.13565  -14.65802 2.79861   1.000 9.04121  ? 106 ILE   A O   1 
ATOM   830  C CB  . ILE   A 1 106 ? -8.18282  -13.48930 3.69151   1.000 10.27108 ? 106 ILE   A CB  1 
ATOM   831  C CG1 . ILE   A 1 106 ? -8.34830  -13.83458 2.21766   1.000 6.20468  ? 106 ILE   A CG1 1 
ATOM   832  C CG2 . ILE   A 1 106 ? -8.97409  -12.29843 4.13900   1.000 13.93204 ? 106 ILE   A CG2 1 
ATOM   833  C CD1 . ILE   A 1 106 ? -9.72574  -14.37017 1.86515   1.000 15.03809 ? 106 ILE   A CD1 1 
ATOM   834  N N   . GLN   A 1 107 ? -6.06198  -15.51386 4.64398   1.000 9.16873  ? 107 GLN   A N   1 
ATOM   835  C CA  . GLN   A 1 107 ? -5.56777  -16.88545 4.70459   1.000 10.88978 ? 107 GLN   A CA  1 
ATOM   836  C C   . GLN   A 1 107 ? -6.53485  -17.83025 3.99295   1.000 8.81466  ? 107 GLN   A C   1 
ATOM   837  O O   . GLN   A 1 107 ? -7.74510  -17.67515 4.10924   1.000 8.08824  ? 107 GLN   A O   1 
ATOM   838  C CB  . GLN   A 1 107 ? -5.42075  -17.31912 6.16736   1.000 12.49800 ? 107 GLN   A CB  1 
ATOM   839  C CG  . GLN   A 1 107 ? -4.33069  -16.56575 6.84825   1.000 13.43009 ? 107 GLN   A CG  1 
ATOM   840  C CD  . GLN   A 1 107 ? -3.01411  -16.96526 6.28194   1.000 16.31521 ? 107 GLN   A CD  1 
ATOM   841  O OE1 . GLN   A 1 107 ? -2.78071  -18.15634 6.02335   1.000 10.96959 ? 107 GLN   A OE1 1 
ATOM   842  N NE2 . GLN   A 1 107 ? -2.17885  -15.97903 5.97100   1.000 15.29153 ? 107 GLN   A NE2 1 
ATOM   843  N N   . PRO   A 1 108 ? -6.06099  -18.81305 3.22048   1.000 8.98186  ? 108 PRO   A N   1 
ATOM   844  C CA  . PRO   A 1 108 ? -6.92428  -19.94805 2.90524   1.000 11.54453 ? 108 PRO   A CA  1 
ATOM   845  C C   . PRO   A 1 108 ? -7.64376  -20.43609 4.15042   1.000 11.92386 ? 108 PRO   A C   1 
ATOM   846  O O   . PRO   A 1 108 ? -7.10712  -20.42510 5.26189   1.000 14.27339 ? 108 PRO   A O   1 
ATOM   847  C CB  . PRO   A 1 108 ? -5.94767  -20.97175 2.27762   1.000 11.92913 ? 108 PRO   A CB  1 
ATOM   848  C CG  . PRO   A 1 108 ? -4.61906  -20.60723 2.81084   1.000 17.42944 ? 108 PRO   A CG  1 
ATOM   849  C CD  . PRO   A 1 108 ? -4.63287  -19.09974 3.00898   1.000 8.90492  ? 108 PRO   A CD  1 
ATOM   850  N N   . GLY   A 1 109 ? -8.92356  -20.75611 3.97483   1.000 10.54684 ? 109 GLY   A N   1 
ATOM   851  C CA  . GLY   A 1 109 ? -9.79799  -21.08946 5.06054   1.000 11.44684 ? 109 GLY   A CA  1 
ATOM   852  C C   . GLY   A 1 109 ? -10.67243 -19.95187 5.53811   1.000 16.25424 ? 109 GLY   A C   1 
ATOM   853  O O   . GLY   A 1 109 ? -11.70112 -20.21516 6.16967   1.000 13.29397 ? 109 GLY   A O   1 
ATOM   854  N N   . GLN   A 1 110 ? -10.30521 -18.70017 5.26346   1.000 10.43964 ? 110 GLN   A N   1 
ATOM   855  C CA  . GLN   A 1 110 ? -11.15305 -17.59063 5.69114   1.000 9.96185  ? 110 GLN   A CA  1 
ATOM   856  C C   . GLN   A 1 110 ? -12.21025 -17.26073 4.63106   1.000 9.18302  ? 110 GLN   A C   1 
ATOM   857  O O   . GLN   A 1 110 ? -12.07194 -17.58924 3.44121   1.000 8.31483  ? 110 GLN   A O   1 
ATOM   858  C CB  . GLN   A 1 110 ? -10.34636 -16.32092 6.01025   1.000 11.75658 ? 110 GLN   A CB  1 
ATOM   859  C CG  . GLN   A 1 110 ? -9.32156  -16.52462 7.14357   1.000 16.72894 ? 110 GLN   A CG  1 
ATOM   860  C CD  . GLN   A 1 110 ? -8.51413  -15.27223 7.50653   1.000 24.39732 ? 110 GLN   A CD  1 
ATOM   861  O OE1 . GLN   A 1 110 ? -7.75215  -14.72412 6.71792   1.000 10.98087 ? 110 GLN   A OE1 1 
ATOM   862  N NE2 . GLN   A 1 110 ? -8.69839  -14.81535 8.75704   1.000 34.36026 ? 110 GLN   A NE2 1 
ATOM   863  N N   . THR   A 1 111 ? -13.27217 -16.59056 5.07262   1.000 8.36780  ? 111 THR   A N   1 
ATOM   864  C CA  . THR   A 1 111 ? -14.39140 -16.27604 4.19041   1.000 9.83549  ? 111 THR   A CA  1 
ATOM   865  C C   . THR   A 1 111 ? -14.46592 -14.78263 3.93097   1.000 11.67819 ? 111 THR   A C   1 
ATOM   866  O O   . THR   A 1 111 ? -13.86901 -13.96782 4.64367   1.000 10.64638 ? 111 THR   A O   1 
ATOM   867  C CB  . THR   A 1 111 ? -15.72234 -16.73530 4.80231   1.000 10.22592 ? 111 THR   A CB  1 
ATOM   868  O OG1 . THR   A 1 111 ? -15.79103 -16.20356 6.13683   1.000 10.30963 ? 111 THR   A OG1 1 
ATOM   869  C CG2 . THR   A 1 111 ? -15.75393 -18.23249 4.83457   1.000 12.30387 ? 111 THR   A CG2 1 
ATOM   870  N N   . PHE   A 1 112 ? -15.24460 -14.43675 2.89780   1.000 10.28790 ? 112 PHE   A N   1 
ATOM   871  C CA  . PHE   A 1 112 ? -15.50776 -13.04833 2.54471   1.000 9.24612  ? 112 PHE   A CA  1 
ATOM   872  C C   . PHE   A 1 112 ? -16.72285 -12.98868 1.64223   1.000 9.04079  ? 112 PHE   A C   1 
ATOM   873  O O   . PHE   A 1 112 ? -17.11369 -13.98296 1.02338   1.000 10.29611 ? 112 PHE   A O   1 
ATOM   874  C CB  . PHE   A 1 112 ? -14.33000 -12.38731 1.82249   1.000 10.56978 ? 112 PHE   A CB  1 
ATOM   875  C CG  . PHE   A 1 112 ? -13.81419 -13.15569 0.61205   1.000 13.51631 ? 112 PHE   A CG  1 
ATOM   876  C CD1 . PHE   A 1 112 ? -12.93897 -14.22104 0.77267   1.000 10.47899 ? 112 PHE   A CD1 1 
ATOM   877  C CD2 . PHE   A 1 112 ? -14.11848 -12.74975 -0.68693  1.000 8.03912  ? 112 PHE   A CD2 1 
ATOM   878  C CE1 . PHE   A 1 112 ? -12.44652 -14.91845 -0.33639  1.000 11.80408 ? 112 PHE   A CE1 1 
ATOM   879  C CE2 . PHE   A 1 112 ? -13.57927 -13.43671 -1.81457  1.000 9.61440  ? 112 PHE   A CE2 1 
ATOM   880  C CZ  . PHE   A 1 112 ? -12.71149 -14.48298 -1.62253  1.000 12.89053 ? 112 PHE   A CZ  1 
ATOM   881  N N   . SER   A 1 113 ? -17.29169 -11.79550 1.55151   1.000 9.99204  ? 113 SER   A N   1 
ATOM   882  C CA  . SER   A 1 113 ? -18.40928 -11.53095 0.66453   1.000 7.46159  ? 113 SER   A CA  1 
ATOM   883  C C   . SER   A 1 113 ? -17.89580 -11.00003 -0.66795  1.000 7.74571  ? 113 SER   A C   1 
ATOM   884  O O   . SER   A 1 113 ? -16.95245 -10.20567 -0.71850  1.000 8.47059  ? 113 SER   A O   1 
ATOM   885  C CB  . SER   A 1 113 ? -19.35054 -10.49741 1.27815   1.000 9.98078  ? 113 SER   A CB  1 
ATOM   886  O OG  . SER   A 1 113 ? -19.73792 -10.89358 2.57292   1.000 9.55927  ? 113 SER   A OG  1 
ATOM   887  N N   . VAL   A 1 114 ? -18.55718 -11.39038 -1.73773  1.000 6.36769  ? 114 VAL   A N   1 
ATOM   888  C CA  . VAL   A 1 114 ? -18.22611 -10.91693 -3.07455  1.000 7.87536  ? 114 VAL   A CA  1 
ATOM   889  C C   . VAL   A 1 114 ? -19.39056 -10.11212 -3.63526  1.000 9.48962  ? 114 VAL   A C   1 
ATOM   890  O O   . VAL   A 1 114 ? -20.52956 -10.59667 -3.65627  1.000 8.73027  ? 114 VAL   A O   1 
ATOM   891  C CB  . VAL   A 1 114 ? -17.90092 -12.10116 -3.99645  1.000 6.46740  ? 114 VAL   A CB  1 
ATOM   892  C CG1 . VAL   A 1 114 ? -17.82188 -11.59261 -5.44485  1.000 10.31492 ? 114 VAL   A CG1 1 
ATOM   893  C CG2 . VAL   A 1 114 ? -16.58863 -12.86858 -3.50424  1.000 9.21337  ? 114 VAL   A CG2 1 
ATOM   894  N N   . LEU   A 1 115 ? -19.10388 -8.91743  -4.14933  1.000 7.63201  ? 115 LEU   A N   1 
ATOM   895  C CA  . LEU   A 1 115 ? -20.12365 -8.14499  -4.86832  1.000 8.03579  ? 115 LEU   A CA  1 
ATOM   896  C C   . LEU   A 1 115 ? -19.82762 -8.27222  -6.35025  1.000 9.24747  ? 115 LEU   A C   1 
ATOM   897  O O   . LEU   A 1 115 ? -18.99177 -7.53454  -6.88611  1.000 9.16391  ? 115 LEU   A O   1 
ATOM   898  C CB  . LEU   A 1 115 ? -20.11570 -6.68927  -4.42936  1.000 7.16864  ? 115 LEU   A CB  1 
ATOM   899  C CG  . LEU   A 1 115 ? -21.12535 -5.76282  -5.11152  1.000 9.50781  ? 115 LEU   A CG  1 
ATOM   900  C CD1 . LEU   A 1 115 ? -22.55760 -6.24775  -4.73551  1.000 11.50313 ? 115 LEU   A CD1 1 
ATOM   901  C CD2 . LEU   A 1 115 ? -20.86850 -4.36379  -4.63357  1.000 8.93829  ? 115 LEU   A CD2 1 
ATOM   902  N N   . ALA   A 1 116 ? -20.49992 -9.21077  -7.01731  1.000 7.15825  ? 116 ALA   A N   1 
ATOM   903  C CA  . ALA   A 1 116 ? -20.28384 -9.36025  -8.44555  1.000 9.67107  ? 116 ALA   A CA  1 
ATOM   904  C C   . ALA   A 1 116 ? -20.86614 -8.16418  -9.17862  1.000 14.90325 ? 116 ALA   A C   1 
ATOM   905  O O   . ALA   A 1 116 ? -22.00592 -7.75667  -8.92340  1.000 17.20609 ? 116 ALA   A O   1 
ATOM   906  C CB  . ALA   A 1 116 ? -20.91807 -10.64868 -8.97605  1.000 10.30108 ? 116 ALA   A CB  1 
ATOM   907  N N   . CYS   A 1 117 ? -20.08713 -7.64412  -10.13534 1.000 8.22099  ? 117 CYS   A N   1 
ATOM   908  C CA  . CYS   A 1 117 ? -20.39287 -6.43793  -10.87692 1.000 12.98942 ? 117 CYS   A CA  1 
ATOM   909  C C   . CYS   A 1 117 ? -20.09734 -6.63714  -12.35293 1.000 14.57308 ? 117 CYS   A C   1 
ATOM   910  O O   . CYS   A 1 117 ? -19.23746 -7.43011  -12.72775 1.000 13.66677 ? 117 CYS   A O   1 
ATOM   911  C CB  . CYS   A 1 117 ? -19.58609 -5.25485  -10.37082 1.000 12.16909 ? 117 CYS   A CB  1 
ATOM   912  S SG  . CYS   A 1 117 ? -19.89302 -4.87592  -8.71840  1.000 21.14201 ? 117 CYS   A SG  1 
ATOM   913  N N   . TYR   A 1 118 ? -20.85092 -5.91737  -13.18024 1.000 17.43906 ? 118 TYR   A N   1 
ATOM   914  C CA  . TYR   A 1 118 ? -20.70477 -5.87997  -14.63565 1.000 16.57007 ? 118 TYR   A CA  1 
ATOM   915  C C   . TYR   A 1 118 ? -20.89678 -4.42658  -15.02701 1.000 18.47678 ? 118 TYR   A C   1 
ATOM   916  O O   . TYR   A 1 118 ? -21.79380 -3.76008  -14.49864 1.000 19.76528 ? 118 TYR   A O   1 
ATOM   917  C CB  . TYR   A 1 118 ? -21.71169 -6.80836  -15.35201 1.000 16.92654 ? 118 TYR   A CB  1 
ATOM   918  C CG  . TYR   A 1 118 ? -21.52050 -8.23408  -14.87566 1.000 17.29710 ? 118 TYR   A CG  1 
ATOM   919  C CD1 . TYR   A 1 118 ? -22.20373 -8.70006  -13.76552 1.000 18.56204 ? 118 TYR   A CD1 1 
ATOM   920  C CD2 . TYR   A 1 118 ? -20.57159 -9.06840  -15.46074 1.000 18.92769 ? 118 TYR   A CD2 1 
ATOM   921  C CE1 . TYR   A 1 118 ? -21.97747 -9.95606  -13.28071 1.000 14.21118 ? 118 TYR   A CE1 1 
ATOM   922  C CE2 . TYR   A 1 118 ? -20.34850 -10.34077 -14.98361 1.000 15.82029 ? 118 TYR   A CE2 1 
ATOM   923  C CZ  . TYR   A 1 118 ? -21.05740 -10.78147 -13.89902 1.000 19.52163 ? 118 TYR   A CZ  1 
ATOM   924  O OH  . TYR   A 1 118 ? -20.82353 -12.04504 -13.39453 1.000 17.79418 ? 118 TYR   A OH  1 
ATOM   925  N N   . ASN   A 1 119 ? -20.00391 -3.92115  -15.87434 1.000 16.55804 ? 119 ASN   A N   1 
ATOM   926  C CA  . ASN   A 1 119 ? -20.06859 -2.53886  -16.34662 1.000 18.46400 ? 119 ASN   A CA  1 
ATOM   927  C C   . ASN   A 1 119 ? -20.20313 -1.55781  -15.19338 1.000 19.96956 ? 119 ASN   A C   1 
ATOM   928  O O   . ASN   A 1 119 ? -20.96055 -0.59000  -15.26371 1.000 20.11858 ? 119 ASN   A O   1 
ATOM   929  C CB  . ASN   A 1 119 ? -21.21493 -2.36998  -17.34118 1.000 23.41345 ? 119 ASN   A CB  1 
ATOM   930  C CG  . ASN   A 1 119 ? -21.09994 -3.32094  -18.48570 1.000 24.71551 ? 119 ASN   A CG  1 
ATOM   931  O OD1 . ASN   A 1 119 ? -20.15749 -3.22271  -19.25823 1.000 29.73305 ? 119 ASN   A OD1 1 
ATOM   932  N ND2 . ASN   A 1 119 ? -22.01410 -4.29104  -18.57370 1.000 26.22285 ? 119 ASN   A ND2 1 
ATOM   933  N N   . GLY   A 1 120 ? -19.48031 -1.81950  -14.10130 1.000 12.52739 ? 120 GLY   A N   1 
ATOM   934  C CA  . GLY   A 1 120 ? -19.57237 -0.96987  -12.92292 1.000 14.36011 ? 120 GLY   A CA  1 
ATOM   935  C C   . GLY   A 1 120 ? -20.86971 -1.04451  -12.12943 1.000 20.79926 ? 120 GLY   A C   1 
ATOM   936  O O   . GLY   A 1 120 ? -21.01379 -0.29164  -11.15577 1.000 17.29125 ? 120 GLY   A O   1 
ATOM   937  N N   . SER   A 1 121 ? -21.84433 -1.88170  -12.52993 1.000 20.38610 ? 121 SER   A N   1 
ATOM   938  C CA  . SER   A 1 121 ? -23.12518 -1.98412  -11.81435 1.000 17.69511 ? 121 SER   A CA  1 
ATOM   939  C C   . SER   A 1 121 ? -23.19367 -3.26455  -11.00391 1.000 18.22947 ? 121 SER   A C   1 
ATOM   940  O O   . SER   A 1 121 ? -23.07241 -4.35509  -11.58526 1.000 17.03732 ? 121 SER   A O   1 
ATOM   941  C CB  . SER   A 1 121 ? -24.30501 -1.95019  -12.77779 1.000 28.72970 ? 121 SER   A CB  1 
ATOM   942  O OG  . SER   A 1 121 ? -24.23879 -0.80757  -13.58920 1.000 36.74553 ? 121 SER   A OG  1 
ATOM   943  N N   . PRO   A 1 122 ? -23.43537 -3.18403  -9.69352  1.000 18.94467 ? 122 PRO   A N   1 
ATOM   944  C CA  . PRO   A 1 122 ? -23.48021 -4.39943  -8.86627  1.000 19.31048 ? 122 PRO   A CA  1 
ATOM   945  C C   . PRO   A 1 122 ? -24.68584 -5.24958  -9.21793  1.000 21.72577 ? 122 PRO   A C   1 
ATOM   946  O O   . PRO   A 1 122 ? -25.79970 -4.73895  -9.37925  1.000 19.00139 ? 122 PRO   A O   1 
ATOM   947  C CB  . PRO   A 1 122 ? -23.56932 -3.86757  -7.42959  1.000 20.48309 ? 122 PRO   A CB  1 
ATOM   948  C CG  . PRO   A 1 122 ? -23.16457 -2.44008  -7.48898  1.000 24.03840 ? 122 PRO   A CG  1 
ATOM   949  C CD  . PRO   A 1 122 ? -23.22128 -1.95666  -8.90911  1.000 21.86473 ? 122 PRO   A CD  1 
ATOM   950  N N   . SER   A 1 123 ? -24.44178 -6.55706  -9.33534  1.000 19.80112 ? 123 SER   A N   1 
ATOM   951  C CA  . SER   A 1 123 ? -25.39549 -7.55663  -9.79591  1.000 21.83053 ? 123 SER   A CA  1 
ATOM   952  C C   . SER   A 1 123 ? -25.89140 -8.48505  -8.69757  1.000 21.67101 ? 123 SER   A C   1 
ATOM   953  O O   . SER   A 1 123 ? -27.08871 -8.77934  -8.65017  1.000 18.31706 ? 123 SER   A O   1 
ATOM   954  C CB  . SER   A 1 123 ? -24.75518 -8.39448  -10.90720 1.000 24.57906 ? 123 SER   A CB  1 
ATOM   955  O OG  . SER   A 1 123 ? -25.48139 -9.58214  -11.14261 1.000 37.57828 ? 123 SER   A OG  1 
ATOM   956  N N   . GLY   A 1 124 ? -25.00151 -9.01552  -7.85746  1.000 10.97176 ? 124 GLY   A N   1 
ATOM   957  C CA  . GLY   A 1 124 ? -25.43869 -9.79635  -6.70603  1.000 12.15486 ? 124 GLY   A CA  1 
ATOM   958  C C   . GLY   A 1 124 ? -24.33443 -9.90252  -5.67898  1.000 13.28815 ? 124 GLY   A C   1 
ATOM   959  O O   . GLY   A 1 124 ? -23.18296 -9.50972  -5.92101  1.000 10.54546 ? 124 GLY   A O   1 
ATOM   960  N N   . VAL   A 1 125 ? -24.69670 -10.39022 -4.49055  1.000 9.00889  ? 125 VAL   A N   1 
ATOM   961  C CA  . VAL   A 1 125 ? -23.72344 -10.55856 -3.41456  1.000 9.71808  ? 125 VAL   A CA  1 
ATOM   962  C C   . VAL   A 1 125 ? -23.79989 -11.99433 -2.90297  1.000 10.49920 ? 125 VAL   A C   1 
ATOM   963  O O   . VAL   A 1 125 ? -24.88403 -12.59084 -2.82668  1.000 12.75763 ? 125 VAL   A O   1 
ATOM   964  C CB  . VAL   A 1 125 ? -23.91734 -9.52910  -2.27572  1.000 12.11657 ? 125 VAL   A CB  1 
ATOM   965  C CG1 . VAL   A 1 125 ? -25.19872 -9.76127  -1.58933  1.000 14.08163 ? 125 VAL   A CG1 1 
ATOM   966  C CG2 . VAL   A 1 125 ? -22.78504 -9.62456  -1.25866  1.000 10.88247 ? 125 VAL   A CG2 1 
ATOM   967  N N   . TYR   A 1 126 ? -22.64382 -12.56882 -2.58600  1.000 9.54991  ? 126 TYR   A N   1 
ATOM   968  C CA  . TYR   A 1 126 ? -22.59465 -13.92985 -2.05414  1.000 9.53923  ? 126 TYR   A CA  1 
ATOM   969  C C   . TYR   A 1 126 ? -21.31783 -14.14199 -1.25223  1.000 13.04650 ? 126 TYR   A C   1 
ATOM   970  O O   . TYR   A 1 126 ? -20.36996 -13.35571 -1.31294  1.000 10.90398 ? 126 TYR   A O   1 
ATOM   971  C CB  . TYR   A 1 126 ? -22.69357 -14.98036 -3.16705  1.000 7.53824  ? 126 TYR   A CB  1 
ATOM   972  C CG  . TYR   A 1 126 ? -21.65416 -14.84040 -4.26442  1.000 8.96219  ? 126 TYR   A CG  1 
ATOM   973  C CD1 . TYR   A 1 126 ? -20.39069 -15.41870 -4.14040  1.000 11.88749 ? 126 TYR   A CD1 1 
ATOM   974  C CD2 . TYR   A 1 126 ? -21.93099 -14.12062 -5.42752  1.000 13.44077 ? 126 TYR   A CD2 1 
ATOM   975  C CE1 . TYR   A 1 126 ? -19.41957 -15.27898 -5.18175  1.000 11.84019 ? 126 TYR   A CE1 1 
ATOM   976  C CE2 . TYR   A 1 126 ? -20.97508 -13.98501 -6.45954  1.000 13.09366 ? 126 TYR   A CE2 1 
ATOM   977  C CZ  . TYR   A 1 126 ? -19.73923 -14.56767 -6.32310  1.000 11.25098 ? 126 TYR   A CZ  1 
ATOM   978  O OH  . TYR   A 1 126 ? -18.79319 -14.46780 -7.32929  1.000 17.91749 ? 126 TYR   A OH  1 
ATOM   979  N N   . GLN   A 1 127 ? -21.29492 -15.24818 -0.52128  1.000 10.47265 ? 127 GLN   A N   1 
ATOM   980  C CA  . GLN   A 1 127 ? -20.24514 -15.53584 0.44443   1.000 11.80159 ? 127 GLN   A CA  1 
ATOM   981  C C   . GLN   A 1 127 ? -19.35440 -16.60695 -0.16699  1.000 13.67591 ? 127 GLN   A C   1 
ATOM   982  O O   . GLN   A 1 127 ? -19.86727 -17.52908 -0.80332  1.000 16.07688 ? 127 GLN   A O   1 
ATOM   983  C CB  . GLN   A 1 127 ? -20.90448 -15.96841 1.76923   1.000 16.62831 ? 127 GLN   A CB  1 
ATOM   984  C CG  . GLN   A 1 127 ? -20.00650 -16.08351 2.89010   1.000 15.05848 ? 127 GLN   A CG  1 
ATOM   985  C CD  . GLN   A 1 127 ? -19.62604 -14.75894 3.49418   1.000 13.74557 ? 127 GLN   A CD  1 
ATOM   986  O OE1 . GLN   A 1 127 ? -19.86136 -13.67985 2.92189   1.000 13.99260 ? 127 GLN   A OE1 1 
ATOM   987  N NE2 . GLN   A 1 127 ? -18.92781 -14.83824 4.61815   1.000 12.36998 ? 127 GLN   A NE2 1 
ATOM   988  N N   . CYS   A 1 128 ? -18.02695 -16.40659 -0.10484  1.000 9.34024  ? 128 CYS   A N   1 
ATOM   989  C CA  . CYS   A 1 128 ? -17.00913 -17.35445 -0.57711  1.000 12.91724 ? 128 CYS   A CA  1 
ATOM   990  C C   . CYS   A 1 128 ? -15.98820 -17.63607 0.50960   1.000 12.05191 ? 128 CYS   A C   1 
ATOM   991  O O   . CYS   A 1 128 ? -15.85700 -16.87573 1.45037   1.000 10.98442 ? 128 CYS   A O   1 
ATOM   992  C CB  . CYS   A 1 128 ? -16.17152 -16.86997 -1.79042  1.000 14.28666 ? 128 CYS   A CB  1 
ATOM   993  S SG  . CYS   A 1 128 ? -16.99111 -16.54821 -3.22053  1.000 29.51392 ? 128 CYS   A SG  1 
ATOM   994  N N   . ALA   A 1 129 ? -15.27625 -18.75854 0.37410   1.000 14.12138 ? 129 ALA   A N   1 
ATOM   995  C CA  . ALA   A 1 129 ? -14.05859 -19.01062 1.13801   1.000 9.55425  ? 129 ALA   A CA  1 
ATOM   996  C C   . ALA   A 1 129 ? -12.84950 -19.07791 0.20775   1.000 11.86818 ? 129 ALA   A C   1 
ATOM   997  O O   . ALA   A 1 129 ? -12.95131 -19.51941 -0.94439  1.000 8.79493  ? 129 ALA   A O   1 
ATOM   998  C CB  . ALA   A 1 129 ? -14.15359 -20.31574 1.92491   1.000 11.45084 ? 129 ALA   A CB  1 
ATOM   999  N N   . MET   A 1 130 ? -11.68804 -18.66371 0.72644   1.000 10.55964 ? 130 MET   A N   1 
ATOM   1000 C CA  . MET   A 1 130 ? -10.41127 -18.83476 0.02993   1.000 7.82713  ? 130 MET   A CA  1 
ATOM   1001 C C   . MET   A 1 130 ? -10.07225 -20.31145 0.21620   1.000 10.90441 ? 130 MET   A C   1 
ATOM   1002 O O   . MET   A 1 130 ? -9.96889  -20.76445 1.35849   1.000 11.88656 ? 130 MET   A O   1 
ATOM   1003 C CB  . MET   A 1 130 ? -9.34422  -17.91410 0.66533   1.000 9.45089  ? 130 MET   A CB  1 
ATOM   1004 C CG  . MET   A 1 130 ? -7.89540  -17.68623 0.01319   1.000 11.07058 ? 130 MET   A CG  1 
ATOM   1005 S SD  . MET   A 1 130 ? -7.93680  -17.72657 -1.74169  1.000 15.45029 ? 130 MET   A SD  1 
ATOM   1006 C CE  . MET   A 1 130 ? -8.35983  -16.02836 -1.98079  1.000 6.67554  ? 130 MET   A CE  1 
ATOM   1007 N N   . ARG   A 1 131 ? -9.98581  -21.08133 -0.87594  1.000 9.07201  ? 131 ARG   A N   1 
ATOM   1008 C CA  . ARG   A 1 131 ? -9.71107  -22.50570 -0.75830  1.000 11.64510 ? 131 ARG   A CA  1 
ATOM   1009 C C   . ARG   A 1 131 ? -8.26142  -22.71528 -0.34725  1.000 11.40701 ? 131 ARG   A C   1 
ATOM   1010 O O   . ARG   A 1 131 ? -7.41750  -21.83767 -0.55725  1.000 10.32441 ? 131 ARG   A O   1 
ATOM   1011 C CB  . ARG   A 1 131 ? -9.95889  -23.24138 -2.07809  1.000 10.41527 ? 131 ARG   A CB  1 
ATOM   1012 C CG  . ARG   A 1 131 ? -11.39010 -23.16797 -2.62698  1.000 12.24711 ? 131 ARG   A CG  1 
ATOM   1013 C CD  . ARG   A 1 131 ? -12.44869 -23.65836 -1.60834  1.000 14.33771 ? 131 ARG   A CD  1 
ATOM   1014 N NE  . ARG   A 1 131 ? -12.04678 -24.93398 -1.02564  1.000 13.17222 ? 131 ARG   A NE  1 
ATOM   1015 C CZ  . ARG   A 1 131 ? -12.68940 -25.52603 -0.02266  1.000 15.89619 ? 131 ARG   A CZ  1 
ATOM   1016 N NH1 . ARG   A 1 131 ? -13.77057 -24.93935 0.49695   1.000 14.02971 ? 131 ARG   A NH1 1 
ATOM   1017 N NH2 . ARG   A 1 131 ? -12.24364 -26.69225 0.45513   1.000 14.74134 ? 131 ARG   A NH2 1 
ATOM   1018 N N   . PRO   A 1 132 ? -7.94618  -23.87716 0.23756   1.000 12.08571 ? 132 PRO   A N   1 
ATOM   1019 C CA  . PRO   A 1 132 ? -6.54081  -24.17591 0.54322   1.000 12.28838 ? 132 PRO   A CA  1 
ATOM   1020 C C   . PRO   A 1 132 ? -5.65609  -24.06094 -0.67363  1.000 14.31553 ? 132 PRO   A C   1 
ATOM   1021 O O   . PRO   A 1 132 ? -4.46971  -23.74462 -0.52738  1.000 14.79840 ? 132 PRO   A O   1 
ATOM   1022 C CB  . PRO   A 1 132 ? -6.60623  -25.60685 1.08630   1.000 12.96153 ? 132 PRO   A CB  1 
ATOM   1023 C CG  . PRO   A 1 132 ? -7.95245  -25.64525 1.80611   1.000 12.56264 ? 132 PRO   A CG  1 
ATOM   1024 C CD  . PRO   A 1 132 ? -8.85650  -24.88747 0.83064   1.000 12.60888 ? 132 PRO   A CD  1 
ATOM   1025 N N   . ASN   A 1 133 ? -6.18832  -24.23794 -1.88880  1.000 12.11077 ? 133 ASN   A N   1 
ATOM   1026 C CA  . ASN   A 1 133 ? -5.32304  -24.08115 -3.05171  1.000 11.56557 ? 133 ASN   A CA  1 
ATOM   1027 C C   . ASN   A 1 133 ? -5.34652  -22.68463 -3.61609  1.000 11.50103 ? 133 ASN   A C   1 
ATOM   1028 O O   . ASN   A 1 133 ? -4.92788  -22.49942 -4.76977  1.000 10.21424 ? 133 ASN   A O   1 
ATOM   1029 C CB  . ASN   A 1 133 ? -5.66493  -25.08552 -4.14879  1.000 11.91087 ? 133 ASN   A CB  1 
ATOM   1030 C CG  . ASN   A 1 133 ? -7.07294  -24.90106 -4.71448  1.000 12.78116 ? 133 ASN   A CG  1 
ATOM   1031 O OD1 . ASN   A 1 133 ? -7.79272  -23.95924 -4.36416  1.000 10.00061 ? 133 ASN   A OD1 1 
ATOM   1032 N ND2 . ASN   A 1 133 ? -7.48142  -25.84170 -5.55635  1.000 13.02845 ? 133 ASN   A ND2 1 
ATOM   1033 N N   . PHE   A 1 134 ? -5.84069  -21.71142 -2.84641  1.000 9.75204  ? 134 PHE   A N   1 
ATOM   1034 C CA  . PHE   A 1 134 ? -5.86672  -20.29593 -3.21013  1.000 12.47124 ? 134 PHE   A CA  1 
ATOM   1035 C C   . PHE   A 1 134 ? -6.79803  -19.98353 -4.37425  1.000 12.59661 ? 134 PHE   A C   1 
ATOM   1036 O O   . PHE   A 1 134 ? -6.63718  -18.95499 -5.04880  1.000 13.36023 ? 134 PHE   A O   1 
ATOM   1037 C CB  . PHE   A 1 134 ? -4.45254  -19.78548 -3.52765  1.000 8.90693  ? 134 PHE   A CB  1 
ATOM   1038 C CG  . PHE   A 1 134 ? -3.58282  -19.66570 -2.31619  1.000 9.61209  ? 134 PHE   A CG  1 
ATOM   1039 C CD1 . PHE   A 1 134 ? -3.72819  -18.60747 -1.44781  1.000 6.97893  ? 134 PHE   A CD1 1 
ATOM   1040 C CD2 . PHE   A 1 134 ? -2.60898  -20.62956 -2.02212  1.000 14.04752 ? 134 PHE   A CD2 1 
ATOM   1041 C CE1 . PHE   A 1 134 ? -2.89678  -18.49483 -0.29094  1.000 12.82349 ? 134 PHE   A CE1 1 
ATOM   1042 C CE2 . PHE   A 1 134 ? -1.78615  -20.52961 -0.85034  1.000 13.14500 ? 134 PHE   A CE2 1 
ATOM   1043 C CZ  . PHE   A 1 134 ? -1.93869  -19.46511 0.00464   1.000 12.86824 ? 134 PHE   A CZ  1 
ATOM   1044 N N   . THR   A 1 135 ? -7.76643  -20.83221 -4.66856  1.000 11.28187 ? 135 THR   A N   1 
ATOM   1045 C CA  . THR   A 1 135 ? -8.78537  -20.44434 -5.63178  1.000 11.48533 ? 135 THR   A CA  1 
ATOM   1046 C C   . THR   A 1 135 ? -10.02734 -20.13668 -4.81932  1.000 10.85730 ? 135 THR   A C   1 
ATOM   1047 O O   . THR   A 1 135 ? -10.07482 -20.41481 -3.61770  1.000 11.95098 ? 135 THR   A O   1 
ATOM   1048 C CB  . THR   A 1 135 ? -9.08333  -21.55903 -6.65259  1.000 10.54361 ? 135 THR   A CB  1 
ATOM   1049 O OG1 . THR   A 1 135 ? -9.61658  -22.67490 -5.95149  1.000 10.32630 ? 135 THR   A OG1 1 
ATOM   1050 C CG2 . THR   A 1 135 ? -7.85150  -22.07054 -7.44824  1.000 10.43462 ? 135 THR   A CG2 1 
ATOM   1051 N N   . ILE   A 1 136 ? -11.04033 -19.57553 -5.47136  1.000 9.49074  ? 136 ILE   A N   1 
ATOM   1052 C CA  . ILE   A 1 136 ? -12.33661 -19.41230 -4.83542  1.000 11.91881 ? 136 ILE   A CA  1 
ATOM   1053 C C   . ILE   A 1 136 ? -13.37715 -19.98548 -5.78293  1.000 12.30564 ? 136 ILE   A C   1 
ATOM   1054 O O   . ILE   A 1 136 ? -13.20293 -19.97522 -7.00462  1.000 10.89264 ? 136 ILE   A O   1 
ATOM   1055 C CB  . ILE   A 1 136 ? -12.64381 -17.94472 -4.46346  1.000 15.89251 ? 136 ILE   A CB  1 
ATOM   1056 C CG1 . ILE   A 1 136 ? -12.88882 -17.12365 -5.71609  1.000 12.34799 ? 136 ILE   A CG1 1 
ATOM   1057 C CG2 . ILE   A 1 136 ? -11.45242 -17.32489 -3.61634  1.000 11.25158 ? 136 ILE   A CG2 1 
ATOM   1058 C CD1 . ILE   A 1 136 ? -13.56854 -15.83040 -5.43418  1.000 12.09322 ? 136 ILE   A CD1 1 
ATOM   1059 N N   . LYS   A 1 137 ? -14.40850 -20.58322 -5.21427  1.000 8.92537  ? 137 LYS   A N   1 
ATOM   1060 C CA  . LYS   A 1 137 ? -15.48004 -21.17040 -6.01047  1.000 13.45444 ? 137 LYS   A CA  1 
ATOM   1061 C C   . LYS   A 1 137 ? -16.53827 -20.08767 -6.09235  1.000 13.81717 ? 137 LYS   A C   1 
ATOM   1062 O O   . LYS   A 1 137 ? -17.44140 -20.02494 -5.26540  1.000 14.88356 ? 137 LYS   A O   1 
ATOM   1063 C CB  . LYS   A 1 137 ? -15.98200 -22.44813 -5.35377  1.000 12.95075 ? 137 LYS   A CB  1 
ATOM   1064 C CG  . LYS   A 1 137 ? -14.99211 -23.60527 -5.46528  1.000 16.88614 ? 137 LYS   A CG  1 
ATOM   1065 C CD  . LYS   A 1 137 ? -15.21574 -24.69091 -4.40173  1.000 23.67634 ? 137 LYS   A CD  1 
ATOM   1066 C CE  . LYS   A 1 137 ? -14.34804 -25.96973 -4.63386  1.000 30.11159 ? 137 LYS   A CE  1 
ATOM   1067 N NZ  . LYS   A 1 137 ? -14.71670 -26.76201 -5.84324  1.000 32.05273 ? 137 LYS   A NZ  1 
ATOM   1068 N N   . GLY   A 1 138 ? -16.38143 -19.19830 -7.07627  1.000 11.80406 ? 138 GLY   A N   1 
ATOM   1069 C CA  . GLY   A 1 138 ? -17.21121 -18.02471 -7.21337  1.000 12.12599 ? 138 GLY   A CA  1 
ATOM   1070 C C   . GLY   A 1 138 ? -18.29151 -18.22710 -8.25428  1.000 11.57501 ? 138 GLY   A C   1 
ATOM   1071 O O   . GLY   A 1 138 ? -18.56066 -19.33675 -8.71091  1.000 15.90345 ? 138 GLY   A O   1 
ATOM   1072 N N   . SER   A 1 139 ? -18.94561 -17.13073 -8.60761  1.000 11.91973 ? 139 SER   A N   1 
ATOM   1073 C CA  . SER   A 1 139 ? -19.92002 -17.13414 -9.69438  1.000 11.21376 ? 139 SER   A CA  1 
ATOM   1074 C C   . SER   A 1 139 ? -19.65746 -15.85780 -10.46468 1.000 11.40009 ? 139 SER   A C   1 
ATOM   1075 O O   . SER   A 1 139 ? -19.98617 -14.77120 -9.97825  1.000 10.44281 ? 139 SER   A O   1 
ATOM   1076 C CB  . SER   A 1 139 ? -21.36333 -17.19112 -9.19359  1.000 15.01655 ? 139 SER   A CB  1 
ATOM   1077 O OG  . SER   A 1 139 ? -22.26119 -16.98759 -10.27476 1.000 14.42631 ? 139 SER   A OG  1 
ATOM   1078 N N   . PHE   A 1 140 ? -19.07850 -15.99459 -11.65404 1.000 11.82636 ? 140 PHE   A N   1 
ATOM   1079 C CA  . PHE   A 1 140 ? -18.47249 -14.88230 -12.38426 1.000 14.05815 ? 140 PHE   A CA  1 
ATOM   1080 C C   . PHE   A 1 140 ? -18.60254 -15.14324 -13.88850 1.000 16.57196 ? 140 PHE   A C   1 
ATOM   1081 O O   . PHE   A 1 140 ? -18.22718 -16.22005 -14.34349 1.000 16.37529 ? 140 PHE   A O   1 
ATOM   1082 C CB  . PHE   A 1 140 ? -16.97141 -14.74408 -12.01677 1.000 12.15169 ? 140 PHE   A CB  1 
ATOM   1083 C CG  . PHE   A 1 140 ? -16.68820 -14.14059 -10.64963 1.000 13.60714 ? 140 PHE   A CG  1 
ATOM   1084 C CD1 . PHE   A 1 140 ? -17.15632 -12.87863 -10.30681 1.000 9.32371  ? 140 PHE   A CD1 1 
ATOM   1085 C CD2 . PHE   A 1 140 ? -15.88281 -14.80618 -9.72613  1.000 14.72221 ? 140 PHE   A CD2 1 
ATOM   1086 C CE1 . PHE   A 1 140 ? -16.86277 -12.31688 -9.05796  1.000 13.99115 ? 140 PHE   A CE1 1 
ATOM   1087 C CE2 . PHE   A 1 140 ? -15.59208 -14.24934 -8.45916  1.000 11.13418 ? 140 PHE   A CE2 1 
ATOM   1088 C CZ  . PHE   A 1 140 ? -16.05963 -13.00437 -8.13568  1.000 10.66461 ? 140 PHE   A CZ  1 
ATOM   1089 N N   . LEU   A 1 141 ? -19.05998 -14.15312 -14.66731 1.000 17.04718 ? 141 LEU   A N   1 
ATOM   1090 C CA  . LEU   A 1 141 ? -19.12137 -14.23955 -16.13929 1.000 20.17563 ? 141 LEU   A CA  1 
ATOM   1091 C C   . LEU   A 1 141 ? -18.18648 -13.20071 -16.75522 1.000 19.94629 ? 141 LEU   A C   1 
ATOM   1092 O O   . LEU   A 1 141 ? -17.61904 -12.38242 -16.04108 1.000 16.84205 ? 141 LEU   A O   1 
ATOM   1093 C CB  . LEU   A 1 141 ? -20.55267 -13.99090 -16.61844 1.000 18.30630 ? 141 LEU   A CB  1 
ATOM   1094 C CG  . LEU   A 1 141 ? -21.56205 -14.91154 -15.92455 1.000 22.82391 ? 141 LEU   A CG  1 
ATOM   1095 C CD1 . LEU   A 1 141 ? -22.96009 -14.37045 -16.03561 1.000 29.10452 ? 141 LEU   A CD1 1 
ATOM   1096 C CD2 . LEU   A 1 141 ? -21.53840 -16.32169 -16.48834 1.000 23.78652 ? 141 LEU   A CD2 1 
ATOM   1097 N N   . ASN   A 1 142 ? -18.06973 -13.20450 -18.09897 1.000 21.48474 ? 142 ASN   A N   1 
ATOM   1098 C CA  . ASN   A 1 142 ? -17.47731 -12.07370 -18.82069 1.000 23.84707 ? 142 ASN   A CA  1 
ATOM   1099 C C   . ASN   A 1 142 ? -17.90274 -10.74471 -18.23664 1.000 20.93093 ? 142 ASN   A C   1 
ATOM   1100 O O   . ASN   A 1 142 ? -19.08673 -10.50303 -17.98689 1.000 22.54870 ? 142 ASN   A O   1 
ATOM   1101 C CB  . ASN   A 1 142 ? -17.82548 -12.09742 -20.31440 1.000 30.10520 ? 142 ASN   A CB  1 
ATOM   1102 C CG  . ASN   A 1 142 ? -16.80368 -12.83969 -21.13392 1.000 41.51475 ? 142 ASN   A CG  1 
ATOM   1103 O OD1 . ASN   A 1 142 ? -15.60826 -12.49961 -21.07927 1.000 45.22861 ? 142 ASN   A OD1 1 
ATOM   1104 N ND2 . ASN   A 1 142 ? -17.24168 -13.83708 -21.91292 1.000 41.00624 ? 142 ASN   A ND2 1 
ATOM   1105 N N   . GLY   A 1 143 ? -16.92319 -9.88021  -18.05419 1.000 16.19011 ? 143 GLY   A N   1 
ATOM   1106 C CA  . GLY   A 1 143 ? -17.16893 -8.55807  -17.55632 1.000 16.51534 ? 143 GLY   A CA  1 
ATOM   1107 C C   . GLY   A 1 143 ? -17.02611 -8.43449  -16.06508 1.000 14.56215 ? 143 GLY   A C   1 
ATOM   1108 O O   . GLY   A 1 143 ? -17.02210 -7.31465  -15.56030 1.000 14.52620 ? 143 GLY   A O   1 
ATOM   1109 N N   . SER   A 1 144 ? -16.91509 -9.54276  -15.34907 1.000 13.82047 ? 144 SER   A N   1 
ATOM   1110 C CA  . SER   A 1 144 ? -16.92663 -9.46075  -13.89357 1.000 14.41823 ? 144 SER   A CA  1 
ATOM   1111 C C   . SER   A 1 144 ? -15.55365 -9.12318  -13.30682 1.000 12.03926 ? 144 SER   A C   1 
ATOM   1112 O O   . SER   A 1 144 ? -15.48340 -8.83212  -12.11126 1.000 9.78170  ? 144 SER   A O   1 
ATOM   1113 C CB  . SER   A 1 144 ? -17.40164 -10.78119 -13.30712 1.000 13.07173 ? 144 SER   A CB  1 
ATOM   1114 O OG  . SER   A 1 144 ? -16.49096 -11.79159 -13.69646 1.000 14.27976 ? 144 SER   A OG  1 
ATOM   1115 N N   . CYS   A 1 145 ? -14.47444 -9.15297  -14.10918 1.000 9.13306  ? 145 CYS   A N   1 
ATOM   1116 C CA  . CYS   A 1 145 ? -13.15435 -8.79169  -13.60250 1.000 10.00177 ? 145 CYS   A CA  1 
ATOM   1117 C C   . CYS   A 1 145 ? -13.18295 -7.43646  -12.90190 1.000 10.80917 ? 145 CYS   A C   1 
ATOM   1118 O O   . CYS   A 1 145 ? -13.93310 -6.52555  -13.27208 1.000 11.62381 ? 145 CYS   A O   1 
ATOM   1119 C CB  . CYS   A 1 145 ? -12.11094 -8.79842  -14.72727 1.000 14.20468 ? 145 CYS   A CB  1 
ATOM   1120 S SG  . CYS   A 1 145 ? -11.77164 -10.45915 -15.31367 1.000 19.76238 ? 145 CYS   A SG  1 
ATOM   1121 N N   . GLY   A 1 146 ? -12.43165 -7.34701  -11.81585 1.000 8.14466  ? 146 GLY   A N   1 
ATOM   1122 C CA  . GLY   A 1 146 ? -12.47319 -6.19005  -10.96468 1.000 9.24561  ? 146 GLY   A CA  1 
ATOM   1123 C C   . GLY   A 1 146 ? -13.54801 -6.15293  -9.89520  1.000 12.39807 ? 146 GLY   A C   1 
ATOM   1124 O O   . GLY   A 1 146 ? -13.54646 -5.18709  -9.11376  1.000 7.17176  ? 146 GLY   A O   1 
ATOM   1125 N N   . SER   A 1 147 ? -14.50054 -7.11654  -9.84711  1.000 7.91544  ? 147 SER   A N   1 
ATOM   1126 C CA  . SER   A 1 147 ? -15.38358 -7.20504  -8.67692  1.000 7.94413  ? 147 SER   A CA  1 
ATOM   1127 C C   . SER   A 1 147 ? -14.52049 -7.53452  -7.46025  1.000 9.00263  ? 147 SER   A C   1 
ATOM   1128 O O   . SER   A 1 147 ? -13.45309 -8.14785  -7.59002  1.000 8.07166  ? 147 SER   A O   1 
ATOM   1129 C CB  . SER   A 1 147 ? -16.45593 -8.30098  -8.84142  1.000 8.22017  ? 147 SER   A CB  1 
ATOM   1130 O OG  . SER   A 1 147 ? -17.14268 -8.22376  -10.09708 1.000 12.38214 ? 147 SER   A OG  1 
ATOM   1131 N N   . VAL   A 1 148 ? -14.94801 -7.11623  -6.26281  1.000 10.57052 ? 148 VAL   A N   1 
ATOM   1132 C CA  . VAL   A 1 148 ? -14.06535 -7.29601  -5.11798  1.000 9.66410  ? 148 VAL   A CA  1 
ATOM   1133 C C   . VAL   A 1 148 ? -14.73888 -8.15095  -4.06484  1.000 10.12746 ? 148 VAL   A C   1 
ATOM   1134 O O   . VAL   A 1 148 ? -15.96765 -8.30535  -4.01622  1.000 8.89913  ? 148 VAL   A O   1 
ATOM   1135 C CB  . VAL   A 1 148 ? -13.60262 -5.97807  -4.48120  1.000 8.13023  ? 148 VAL   A CB  1 
ATOM   1136 C CG1 . VAL   A 1 148 ? -12.80873 -5.17539  -5.53936  1.000 7.73042  ? 148 VAL   A CG1 1 
ATOM   1137 C CG2 . VAL   A 1 148 ? -14.78377 -5.24668  -4.01322  1.000 8.38781  ? 148 VAL   A CG2 1 
ATOM   1138 N N   . GLY   A 1 149 ? -13.89518 -8.71716  -3.22104  1.000 6.58970  ? 149 GLY   A N   1 
ATOM   1139 C CA  . GLY   A 1 149 ? -14.33105 -9.47802  -2.06157  1.000 3.53396  ? 149 GLY   A CA  1 
ATOM   1140 C C   . GLY   A 1 149 ? -13.97461 -8.67725  -0.82780  1.000 6.94258  ? 149 GLY   A C   1 
ATOM   1141 O O   . GLY   A 1 149 ? -12.93868 -8.01170  -0.78798  1.000 5.19977  ? 149 GLY   A O   1 
ATOM   1142 N N   . PHE   A 1 150 ? -14.79429 -8.78725  0.21230   1.000 7.45455  ? 150 PHE   A N   1 
ATOM   1143 C CA  . PHE   A 1 150 ? -14.57712 -7.94382  1.38283   1.000 7.73958  ? 150 PHE   A CA  1 
ATOM   1144 C C   . PHE   A 1 150 ? -15.22537 -8.55565  2.62018   1.000 9.97863  ? 150 PHE   A C   1 
ATOM   1145 O O   . PHE   A 1 150 ? -16.09687 -9.43037  2.53598   1.000 7.79892  ? 150 PHE   A O   1 
ATOM   1146 C CB  . PHE   A 1 150 ? -15.16519 -6.55732  1.14461   1.000 10.69060 ? 150 PHE   A CB  1 
ATOM   1147 C CG  . PHE   A 1 150 ? -16.61912 -6.61102  0.89968   1.000 9.26853  ? 150 PHE   A CG  1 
ATOM   1148 C CD1 . PHE   A 1 150 ? -17.09832 -6.89971  -0.38660  1.000 10.65573 ? 150 PHE   A CD1 1 
ATOM   1149 C CD2 . PHE   A 1 150 ? -17.51394 -6.42134  1.95093   1.000 10.99486 ? 150 PHE   A CD2 1 
ATOM   1150 C CE1 . PHE   A 1 150 ? -18.47387 -7.01152  -0.61900  1.000 10.96896 ? 150 PHE   A CE1 1 
ATOM   1151 C CE2 . PHE   A 1 150 ? -18.87453 -6.50068  1.73528   1.000 13.89480 ? 150 PHE   A CE2 1 
ATOM   1152 C CZ  . PHE   A 1 150 ? -19.35783 -6.82595  0.44311   1.000 12.21026 ? 150 PHE   A CZ  1 
ATOM   1153 N N   . ASN   A 1 151 ? -14.81037 -8.03810  3.77034   1.000 11.50740 ? 151 ASN   A N   1 
ATOM   1154 C CA  . ASN   A 1 151 ? -15.46840 -8.25365  5.04583   1.000 13.93214 ? 151 ASN   A CA  1 
ATOM   1155 C C   . ASN   A 1 151 ? -15.69077 -6.88267  5.67069   1.000 12.57996 ? 151 ASN   A C   1 
ATOM   1156 O O   . ASN   A 1 151 ? -15.01988 -5.90377  5.32907   1.000 12.82522 ? 151 ASN   A O   1 
ATOM   1157 C CB  . ASN   A 1 151 ? -14.62054 -9.11311  5.99370   1.000 11.38479 ? 151 ASN   A CB  1 
ATOM   1158 C CG  . ASN   A 1 151 ? -14.60680 -10.59702 5.62099   1.000 15.62128 ? 151 ASN   A CG  1 
ATOM   1159 O OD1 . ASN   A 1 151 ? -15.57930 -11.34777 5.86319   1.000 13.77877 ? 151 ASN   A OD1 1 
ATOM   1160 N ND2 . ASN   A 1 151 ? -13.49872 -11.02590 4.99068   1.000 9.50129  ? 151 ASN   A ND2 1 
ATOM   1161 N N   . ILE   A 1 152 ? -16.61017 -6.83705  6.62717   1.000 13.59290 ? 152 ILE   A N   1 
ATOM   1162 C CA  . ILE   A 1 152 ? -16.98705 -5.60607  7.30179   1.000 15.22609 ? 152 ILE   A CA  1 
ATOM   1163 C C   . ILE   A 1 152 ? -16.82227 -5.85906  8.77739   1.000 27.51043 ? 152 ILE   A C   1 
ATOM   1164 O O   . ILE   A 1 152 ? -17.33945 -6.85466  9.28900   1.000 22.49976 ? 152 ILE   A O   1 
ATOM   1165 C CB  . ILE   A 1 152 ? -18.43913 -5.20438  7.01582   1.000 20.93591 ? 152 ILE   A CB  1 
ATOM   1166 C CG1 . ILE   A 1 152 ? -18.73819 -5.33562  5.53003   1.000 20.30014 ? 152 ILE   A CG1 1 
ATOM   1167 C CG2 . ILE   A 1 152 ? -18.67561 -3.80330  7.53208   1.000 26.09993 ? 152 ILE   A CG2 1 
ATOM   1168 C CD1 . ILE   A 1 152 ? -18.04596 -4.33153  4.76080   1.000 21.41874 ? 152 ILE   A CD1 1 
ATOM   1169 N N   . ASP   A 1 153 ? -16.08860 -4.97865  9.44707   1.000 31.52892 ? 153 ASP   A N   1 
ATOM   1170 C CA  . ASP   A 1 153 ? -15.81858 -5.08625  10.87441  1.000 40.41934 ? 153 ASP   A CA  1 
ATOM   1171 C C   . ASP   A 1 153 ? -16.23453 -3.74996  11.48114  1.000 44.11687 ? 153 ASP   A C   1 
ATOM   1172 O O   . ASP   A 1 153 ? -15.58696 -2.72141  11.25147  1.000 40.37159 ? 153 ASP   A O   1 
ATOM   1173 C CB  . ASP   A 1 153 ? -14.34839 -5.42129  11.12294  1.000 37.60321 ? 153 ASP   A CB  1 
ATOM   1174 C CG  . ASP   A 1 153 ? -14.14115 -6.31217  12.33884  1.000 52.41135 ? 153 ASP   A CG  1 
ATOM   1175 O OD1 . ASP   A 1 153 ? -14.93523 -6.18752  13.30458  1.000 49.08024 ? 153 ASP   A OD1 1 
ATOM   1176 O OD2 . ASP   A 1 153 ? -13.18738 -7.13686  12.31708  1.000 54.19673 ? 153 ASP   A OD2 1 
ATOM   1177 N N   . TYR   A 1 154 ? -17.33577 -3.77169  12.22594  1.000 48.22015 ? 154 TYR   A N   1 
ATOM   1178 C CA  . TYR   A 1 154 ? -18.16010 -2.59581  12.47518  1.000 55.05827 ? 154 TYR   A CA  1 
ATOM   1179 C C   . TYR   A 1 154 ? -18.38639 -1.77778  11.20375  1.000 53.43926 ? 154 TYR   A C   1 
ATOM   1180 O O   . TYR   A 1 154 ? -19.10869 -2.21923  10.30511  1.000 54.96025 ? 154 TYR   A O   1 
ATOM   1181 C CB  . TYR   A 1 154 ? -17.57272 -1.71920  13.58091  1.000 55.58830 ? 154 TYR   A CB  1 
ATOM   1182 C CG  . TYR   A 1 154 ? -18.60344 -0.72129  14.09644  1.000 69.83524 ? 154 TYR   A CG  1 
ATOM   1183 C CD1 . TYR   A 1 154 ? -19.96007 -1.07421  14.18783  1.000 73.64383 ? 154 TYR   A CD1 1 
ATOM   1184 C CD2 . TYR   A 1 154 ? -18.23408 0.56662   14.49124  1.000 70.75366 ? 154 TYR   A CD2 1 
ATOM   1185 C CE1 . TYR   A 1 154 ? -20.92124 -0.16669  14.65384  1.000 78.10929 ? 154 TYR   A CE1 1 
ATOM   1186 C CE2 . TYR   A 1 154 ? -19.18738 1.48103   14.96608  1.000 73.98785 ? 154 TYR   A CE2 1 
ATOM   1187 C CZ  . TYR   A 1 154 ? -20.52827 1.10791   15.04375  1.000 81.65122 ? 154 TYR   A CZ  1 
ATOM   1188 O OH  . TYR   A 1 154 ? -21.47302 2.00605   15.50861  1.000 79.24201 ? 154 TYR   A OH  1 
ATOM   1189 N N   . ASP   A 1 155 ? -17.79234 -0.58901  11.11206  1.000 45.80869 ? 155 ASP   A N   1 
ATOM   1190 C CA  . ASP   A 1 155 ? -18.06330 0.33767   10.01405  1.000 44.99216 ? 155 ASP   A CA  1 
ATOM   1191 C C   . ASP   A 1 155 ? -16.98997 0.33054   8.92715   1.000 33.81311 ? 155 ASP   A C   1 
ATOM   1192 O O   . ASP   A 1 155 ? -17.08728 1.11014   7.96904   1.000 27.93934 ? 155 ASP   A O   1 
ATOM   1193 C CB  . ASP   A 1 155 ? -18.21399 1.75789   10.57281  1.000 51.96316 ? 155 ASP   A CB  1 
ATOM   1194 C CG  . ASP   A 1 155 ? -16.99801 2.19415   11.38456  1.000 53.17856 ? 155 ASP   A CG  1 
ATOM   1195 O OD1 . ASP   A 1 155 ? -16.25441 1.28770   11.84419  1.000 50.22947 ? 155 ASP   A OD1 1 
ATOM   1196 O OD2 . ASP   A 1 155 ? -16.80347 3.42687   11.56801  1.000 53.74771 ? 155 ASP   A OD2 1 
ATOM   1197 N N   . CYS   A 1 156 ? -15.97334 -0.51546  9.05927   1.000 27.52401 ? 156 CYS   A N   1 
ATOM   1198 C CA  . CYS   A 1 156 ? -14.77142 -0.47104  8.23332   1.000 20.53471 ? 156 CYS   A CA  1 
ATOM   1199 C C   . CYS   A 1 156 ? -14.77326 -1.65406  7.27777   1.000 19.57570 ? 156 CYS   A C   1 
ATOM   1200 O O   . CYS   A 1 156 ? -14.92877 -2.80043  7.71429   1.000 18.11659 ? 156 CYS   A O   1 
ATOM   1201 C CB  . CYS   A 1 156 ? -13.51935 -0.50502  9.10581   1.000 23.64979 ? 156 CYS   A CB  1 
ATOM   1202 S SG  . CYS   A 1 156 ? -11.97941 -0.75352  8.17354   1.000 19.53480 ? 156 CYS   A SG  1 
ATOM   1203 N N   . VAL   A 1 157 ? -14.62717 -1.37209  5.97948   1.000 14.99556 ? 157 VAL   A N   1 
ATOM   1204 C CA  . VAL   A 1 157 ? -14.60284 -2.40258  4.94953   1.000 12.54926 ? 157 VAL   A CA  1 
ATOM   1205 C C   . VAL   A 1 157 ? -13.16554 -2.87779  4.80478   1.000 13.61328 ? 157 VAL   A C   1 
ATOM   1206 O O   . VAL   A 1 157 ? -12.29974 -2.09639  4.39745   1.000 12.27326 ? 157 VAL   A O   1 
ATOM   1207 C CB  . VAL   A 1 157 ? -15.11334 -1.86951  3.59928   1.000 11.18397 ? 157 VAL   A CB  1 
ATOM   1208 C CG1 . VAL   A 1 157 ? -15.10655 -2.98738  2.54198   1.000 9.86236  ? 157 VAL   A CG1 1 
ATOM   1209 C CG2 . VAL   A 1 157 ? -16.51161 -1.22494  3.71772   1.000 13.79861 ? 157 VAL   A CG2 1 
ATOM   1210 N N   . SER   A 1 158 ? -12.91327 -4.15088  5.08137   1.000 11.96939 ? 158 SER   A N   1 
ATOM   1211 C CA  . SER   A 1 158 ? -11.59794 -4.74181  4.80743   1.000 12.65347 ? 158 SER   A CA  1 
ATOM   1212 C C   . SER   A 1 158 ? -11.66825 -5.42931  3.45651   1.000 9.46090  ? 158 SER   A C   1 
ATOM   1213 O O   . SER   A 1 158 ? -12.24611 -6.51633  3.33504   1.000 9.12338  ? 158 SER   A O   1 
ATOM   1214 C CB  . SER   A 1 158 ? -11.20873 -5.71176  5.91367   1.000 14.03839 ? 158 SER   A CB  1 
ATOM   1215 O OG  . SER   A 1 158 ? -10.90278 -4.91624  7.05155   1.000 15.32225 ? 158 SER   A OG  1 
ATOM   1216 N N   . PHE   A 1 159 ? -11.11213 -4.79128  2.42668   1.000 10.52072 ? 159 PHE   A N   1 
ATOM   1217 C CA  . PHE   A 1 159 ? -11.11943 -5.38376  1.08806   1.000 9.12401  ? 159 PHE   A CA  1 
ATOM   1218 C C   . PHE   A 1 159 ? -10.04439 -6.46297  1.03070   1.000 9.71887  ? 159 PHE   A C   1 
ATOM   1219 O O   . PHE   A 1 159 ? -8.88504  -6.19422  1.34665   1.000 9.71477  ? 159 PHE   A O   1 
ATOM   1220 C CB  . PHE   A 1 159 ? -10.82204 -4.33938  0.00824   1.000 7.42181  ? 159 PHE   A CB  1 
ATOM   1221 C CG  . PHE   A 1 159 ? -11.90905 -3.31548  -0.17764  1.000 11.55714 ? 159 PHE   A CG  1 
ATOM   1222 C CD1 . PHE   A 1 159 ? -13.05247 -3.64897  -0.88853  1.000 7.37384  ? 159 PHE   A CD1 1 
ATOM   1223 C CD2 . PHE   A 1 159 ? -11.78959 -2.03737  0.38257   1.000 8.03057  ? 159 PHE   A CD2 1 
ATOM   1224 C CE1 . PHE   A 1 159 ? -14.07617 -2.72742  -1.07134  1.000 7.27371  ? 159 PHE   A CE1 1 
ATOM   1225 C CE2 . PHE   A 1 159 ? -12.81621 -1.09587  0.22121   1.000 7.47497  ? 159 PHE   A CE2 1 
ATOM   1226 C CZ  . PHE   A 1 159 ? -13.95539 -1.44575  -0.49925  1.000 12.32855 ? 159 PHE   A CZ  1 
ATOM   1227 N N   . CYS   A 1 160 ? -10.38899 -7.67012  0.57659   1.000 7.39665  ? 160 CYS   A N   1 
ATOM   1228 C CA  . CYS   A 1 160 ? -9.35652  -8.68609  0.50562   1.000 6.30000  ? 160 CYS   A CA  1 
ATOM   1229 C C   . CYS   A 1 160 ? -9.12189  -9.30985  -0.86174  1.000 8.80484  ? 160 CYS   A C   1 
ATOM   1230 O O   . CYS   A 1 160 ? -8.16616  -10.07887 -0.98436  1.000 7.83242  ? 160 CYS   A O   1 
ATOM   1231 C CB  . CYS   A 1 160 ? -9.63941  -9.80441  1.52510   1.000 5.00005  ? 160 CYS   A CB  1 
ATOM   1232 S SG  . CYS   A 1 160 ? -11.32691 -10.47812 1.30843   1.000 7.80905  ? 160 CYS   A SG  1 
ATOM   1233 N N   . TYR   A 1 161 ? -9.94778  -9.02909  -1.87881  1.000 4.59712  ? 161 TYR   A N   1 
ATOM   1234 C CA  . TYR   A 1 161 ? -9.92390  -9.83866  -3.10062  1.000 6.38852  ? 161 TYR   A CA  1 
ATOM   1235 C C   . TYR   A 1 161 ? -10.34506 -8.98010  -4.27486  1.000 8.61337  ? 161 TYR   A C   1 
ATOM   1236 O O   . TYR   A 1 161 ? -11.32864 -8.23313  -4.16876  1.000 6.69520  ? 161 TYR   A O   1 
ATOM   1237 C CB  . TYR   A 1 161 ? -10.86616 -11.04110 -3.01365  1.000 6.09853  ? 161 TYR   A CB  1 
ATOM   1238 C CG  . TYR   A 1 161 ? -10.89375 -11.86137 -4.29626  1.000 6.08392  ? 161 TYR   A CG  1 
ATOM   1239 C CD1 . TYR   A 1 161 ? -9.88906  -12.77422 -4.54362  1.000 6.97869  ? 161 TYR   A CD1 1 
ATOM   1240 C CD2 . TYR   A 1 161 ? -11.96413 -11.76210 -5.23062  1.000 6.81596  ? 161 TYR   A CD2 1 
ATOM   1241 C CE1 . TYR   A 1 161 ? -9.88960  -13.54546 -5.67551  1.000 7.05782  ? 161 TYR   A CE1 1 
ATOM   1242 C CE2 . TYR   A 1 161 ? -11.96759 -12.52803 -6.39768  1.000 5.84851  ? 161 TYR   A CE2 1 
ATOM   1243 C CZ  . TYR   A 1 161 ? -10.94317 -13.41741 -6.60444  1.000 6.94601  ? 161 TYR   A CZ  1 
ATOM   1244 O OH  . TYR   A 1 161 ? -10.91789 -14.19265 -7.74301  1.000 8.98093  ? 161 TYR   A OH  1 
ATOM   1245 N N   . MET   A 1 162 ? -9.62981  -9.07611  -5.39201  1.000 7.07312  ? 162 MET   A N   1 
ATOM   1246 C CA  . MET   A 1 162 ? -10.17612 -8.49255  -6.60566  1.000 6.98545  ? 162 MET   A CA  1 
ATOM   1247 C C   . MET   A 1 162 ? -10.07606 -9.57335  -7.67363  1.000 7.65393  ? 162 MET   A C   1 
ATOM   1248 O O   . MET   A 1 162 ? -9.07257  -10.29450 -7.74811  1.000 6.25180  ? 162 MET   A O   1 
ATOM   1249 C CB  . MET   A 1 162 ? -9.51848  -7.13692  -7.01036  1.000 11.69715 ? 162 MET   A CB  1 
ATOM   1250 C CG  . MET   A 1 162 ? -9.74444  -6.73592  -8.48629  1.000 8.73063  ? 162 MET   A CG  1 
ATOM   1251 S SD  . MET   A 1 162 ? -8.89295  -5.21181  -8.91825  1.000 13.19486 ? 162 MET   A SD  1 
ATOM   1252 C CE  . MET   A 1 162 ? -9.78755  -3.92312  -8.22452  1.000 13.07166 ? 162 MET   A CE  1 
ATOM   1253 N N   . HIS   A 1 163 ? -11.17264 -9.76154  -8.39936  1.000 7.07079  ? 163 HIS   A N   1 
ATOM   1254 C CA  . HIS   A 1 163 ? -11.29195 -10.86882 -9.35043  1.000 8.15731  ? 163 HIS   A CA  1 
ATOM   1255 C C   . HIS   A 1 163 ? -10.50311 -10.60983 -10.63408 1.000 5.53084  ? 163 HIS   A C   1 
ATOM   1256 O O   . HIS   A 1 163 ? -10.62013 -9.54166  -11.23226 1.000 7.26663  ? 163 HIS   A O   1 
ATOM   1257 C CB  . HIS   A 1 163 ? -12.76228 -11.07989 -9.69174  1.000 8.47810  ? 163 HIS   A CB  1 
ATOM   1258 C CG  . HIS   A 1 163 ? -12.98378 -12.29865 -10.51362 1.000 8.01619  ? 163 HIS   A CG  1 
ATOM   1259 N ND1 . HIS   A 1 163 ? -12.40694 -13.50237 -10.18106 1.000 8.13255  ? 163 HIS   A ND1 1 
ATOM   1260 C CD2 . HIS   A 1 163 ? -13.71766 -12.51836 -11.63164 1.000 10.09627 ? 163 HIS   A CD2 1 
ATOM   1261 C CE1 . HIS   A 1 163 ? -12.74086 -14.40937 -11.08372 1.000 10.88811 ? 163 HIS   A CE1 1 
ATOM   1262 N NE2 . HIS   A 1 163 ? -13.52530 -13.83662 -11.97937 1.000 10.58255 ? 163 HIS   A NE2 1 
ATOM   1263 N N   . HIS   A 1 164 ? -9.76060  -11.63106 -11.10574 1.000 9.83509  ? 164 HIS   A N   1 
ATOM   1264 C CA  . HIS   A 1 164 ? -8.98165  -11.50436 -12.34125 1.000 9.05984  ? 164 HIS   A CA  1 
ATOM   1265 C C   . HIS   A 1 164 ? -9.30577  -12.54074 -13.41471 1.000 12.42883 ? 164 HIS   A C   1 
ATOM   1266 O O   . HIS   A 1 164 ? -9.25767  -12.20538 -14.60402 1.000 15.78924 ? 164 HIS   A O   1 
ATOM   1267 C CB  . HIS   A 1 164 ? -7.46986  -11.57528 -12.03292 1.000 7.34421  ? 164 HIS   A CB  1 
ATOM   1268 C CG  . HIS   A 1 164 ? -6.93160  -10.33557 -11.38019 1.000 7.75517  ? 164 HIS   A CG  1 
ATOM   1269 N ND1 . HIS   A 1 164 ? -6.00512  -9.51117  -11.98486 1.000 8.90490  ? 164 HIS   A ND1 1 
ATOM   1270 C CD2 . HIS   A 1 164 ? -7.18162  -9.79163  -10.16550 1.000 10.77963 ? 164 HIS   A CD2 1 
ATOM   1271 C CE1 . HIS   A 1 164 ? -5.69765  -8.51700  -11.16898 1.000 12.11831 ? 164 HIS   A CE1 1 
ATOM   1272 N NE2 . HIS   A 1 164 ? -6.38774  -8.66860  -10.04755 1.000 8.99612  ? 164 HIS   A NE2 1 
ATOM   1273 N N   . MET   A 1 165 ? -9.67727  -13.76569 -13.05075 1.000 12.08461 ? 165 MET   A N   1 
ATOM   1274 C CA  . MET   A 1 165 ? -9.71643  -14.79348 -14.08874 1.000 14.83131 ? 165 MET   A CA  1 
ATOM   1275 C C   . MET   A 1 165 ? -10.43041 -16.04325 -13.61217 1.000 15.27199 ? 165 MET   A C   1 
ATOM   1276 O O   . MET   A 1 165 ? -10.60353 -16.27028 -12.41373 1.000 11.92231 ? 165 MET   A O   1 
ATOM   1277 C CB  . MET   A 1 165 ? -8.28241  -15.06054 -14.55590 1.000 17.70191 ? 165 MET   A CB  1 
ATOM   1278 C CG  . MET   A 1 165 ? -7.47879  -15.53424 -13.39210 1.000 16.61552 ? 165 MET   A CG  1 
ATOM   1279 S SD  . MET   A 1 165 ? -5.67299  -15.67708 -13.54046 1.000 27.55016 ? 165 MET   A SD  1 
ATOM   1280 C CE  . MET   A 1 165 ? -5.54476  -17.34537 -14.07545 1.000 22.83605 ? 165 MET   A CE  1 
ATOM   1281 N N   . GLU   A 1 166 ? -10.91087 -16.81119 -14.58281 1.000 13.12082 ? 166 GLU   A N   1 
ATOM   1282 C CA  . GLU   A 1 166 ? -11.52119 -18.10485 -14.32905 1.000 14.06949 ? 166 GLU   A CA  1 
ATOM   1283 C C   . GLU   A 1 166 ? -10.59581 -19.17460 -14.86790 1.000 17.07154 ? 166 GLU   A C   1 
ATOM   1284 O O   . GLU   A 1 166 ? -10.07990 -19.05122 -15.98586 1.000 17.42580 ? 166 GLU   A O   1 
ATOM   1285 C CB  . GLU   A 1 166 ? -12.89486 -18.21996 -14.98415 1.000 13.39394 ? 166 GLU   A CB  1 
ATOM   1286 C CG  . GLU   A 1 166 ? -13.49389 -19.62979 -14.87390 1.000 20.13267 ? 166 GLU   A CG  1 
ATOM   1287 C CD  . GLU   A 1 166 ? -14.96121 -19.65544 -15.27396 1.000 19.64316 ? 166 GLU   A CD  1 
ATOM   1288 O OE1 . GLU   A 1 166 ? -15.36386 -20.52692 -16.07435 1.000 21.84062 ? 166 GLU   A OE1 1 
ATOM   1289 O OE2 . GLU   A 1 166 ? -15.72571 -18.81549 -14.76311 1.000 17.86764 ? 166 GLU   A OE2 1 
ATOM   1290 N N   . LEU   A 1 167 ? -10.38413 -20.19731 -14.07291 1.000 15.12582 ? 167 LEU   A N   1 
ATOM   1291 C CA  . LEU   A 1 167 ? -9.50498  -21.30507 -14.41385 1.000 16.83359 ? 167 LEU   A CA  1 
ATOM   1292 C C   . LEU   A 1 167 ? -10.31518 -22.38571 -15.10649 1.000 23.40800 ? 167 LEU   A C   1 
ATOM   1293 O O   . LEU   A 1 167 ? -11.55608 -22.37111 -15.04362 1.000 23.90598 ? 167 LEU   A O   1 
ATOM   1294 C CB  . LEU   A 1 167 ? -8.86072  -21.82176 -13.13654 1.000 17.78026 ? 167 LEU   A CB  1 
ATOM   1295 C CG  . LEU   A 1 167 ? -7.87625  -20.87676 -12.43799 1.000 18.51117 ? 167 LEU   A CG  1 
ATOM   1296 C CD1 . LEU   A 1 167 ? -7.60880  -21.35858 -11.06773 1.000 16.13430 ? 167 LEU   A CD1 1 
ATOM   1297 C CD2 . LEU   A 1 167 ? -6.57052  -20.92026 -13.17267 1.000 20.35110 ? 167 LEU   A CD2 1 
ATOM   1298 N N   . PRO   A 1 168 ? -9.65421  -23.35855 -15.75841 1.000 23.67949 ? 168 PRO   A N   1 
ATOM   1299 C CA  . PRO   A 1 168 ? -10.41115 -24.29865 -16.59833 1.000 21.02887 ? 168 PRO   A CA  1 
ATOM   1300 C C   . PRO   A 1 168 ? -11.42283 -25.11954 -15.83314 1.000 25.06968 ? 168 PRO   A C   1 
ATOM   1301 O O   . PRO   A 1 168 ? -12.43669 -25.51706 -16.42094 1.000 28.14041 ? 168 PRO   A O   1 
ATOM   1302 C CB  . PRO   A 1 168 ? -9.31723  -25.18253 -17.22340 1.000 21.39311 ? 168 PRO   A CB  1 
ATOM   1303 C CG  . PRO   A 1 168 ? -8.08305  -24.35905 -17.20358 1.000 28.20988 ? 168 PRO   A CG  1 
ATOM   1304 C CD  . PRO   A 1 168 ? -8.19484  -23.55295 -15.91418 1.000 25.03432 ? 168 PRO   A CD  1 
ATOM   1305 N N   . THR   A 1 169 ? -11.21874 -25.36223 -14.53736 1.000 20.91695 ? 169 THR   A N   1 
ATOM   1306 C CA  . THR   A 1 169 ? -12.20776 -26.12472 -13.78857 1.000 21.68034 ? 169 THR   A CA  1 
ATOM   1307 C C   . THR   A 1 169 ? -13.42661 -25.29557 -13.40893 1.000 20.07294 ? 169 THR   A C   1 
ATOM   1308 O O   . THR   A 1 169 ? -14.30246 -25.80491 -12.71482 1.000 18.57427 ? 169 THR   A O   1 
ATOM   1309 C CB  . THR   A 1 169 ? -11.58171 -26.73592 -12.52147 1.000 25.12307 ? 169 THR   A CB  1 
ATOM   1310 O OG1 . THR   A 1 169 ? -10.86750 -25.72527 -11.79222 1.000 21.06390 ? 169 THR   A OG1 1 
ATOM   1311 C CG2 . THR   A 1 169 ? -10.62184 -27.87649 -12.89599 1.000 26.07647 ? 169 THR   A CG2 1 
ATOM   1312 N N   . GLY   A 1 170 ? -13.49842 -24.02844 -13.79478 1.000 18.56685 ? 170 GLY   A N   1 
ATOM   1313 C CA  . GLY   A 1 170 ? -14.63052 -23.21932 -13.39848 1.000 18.69020 ? 170 GLY   A CA  1 
ATOM   1314 C C   . GLY   A 1 170 ? -14.45784 -22.47463 -12.09625 1.000 18.74490 ? 170 GLY   A C   1 
ATOM   1315 O O   . GLY   A 1 170 ? -15.39711 -21.79683 -11.66853 1.000 17.02800 ? 170 GLY   A O   1 
ATOM   1316 N N   . VAL   A 1 171 ? -13.30367 -22.58309 -11.44443 1.000 14.42190 ? 171 VAL   A N   1 
ATOM   1317 C CA  . VAL   A 1 171 ? -13.02833 -21.82532 -10.22010 1.000 13.45576 ? 171 VAL   A CA  1 
ATOM   1318 C C   . VAL   A 1 171 ? -12.24992 -20.56787 -10.59232 1.000 13.23861 ? 171 VAL   A C   1 
ATOM   1319 O O   . VAL   A 1 171 ? -11.84094 -20.37558 -11.73508 1.000 11.05417 ? 171 VAL   A O   1 
ATOM   1320 C CB  . VAL   A 1 171 ? -12.28379 -22.68116 -9.15482  1.000 12.90936 ? 171 VAL   A CB  1 
ATOM   1321 C CG1 . VAL   A 1 171 ? -13.10262 -23.96019 -8.80284  1.000 15.85888 ? 171 VAL   A CG1 1 
ATOM   1322 C CG2 . VAL   A 1 171 ? -10.83241 -22.98945 -9.54926  1.000 13.15110 ? 171 VAL   A CG2 1 
ATOM   1323 N N   . HIS   A 1 172 ? -12.04860 -19.68509 -9.61768  1.000 8.56506  ? 172 HIS   A N   1 
ATOM   1324 C CA  . HIS   A 1 172 ? -11.65743 -18.30991 -9.89199  1.000 10.35060 ? 172 HIS   A CA  1 
ATOM   1325 C C   . HIS   A 1 172 ? -10.39906 -17.95358 -9.12598  1.000 10.60618 ? 172 HIS   A C   1 
ATOM   1326 O O   . HIS   A 1 172 ? -10.13099 -18.50087 -8.06302  1.000 6.81009  ? 172 HIS   A O   1 
ATOM   1327 C CB  . HIS   A 1 172 ? -12.81409 -17.39506 -9.53773  1.000 10.04908 ? 172 HIS   A CB  1 
ATOM   1328 C CG  . HIS   A 1 172 ? -14.02978 -17.71436 -10.33728 1.000 12.50450 ? 172 HIS   A CG  1 
ATOM   1329 N ND1 . HIS   A 1 172 ? -15.11245 -18.39695 -9.81942  1.000 11.36191 ? 172 HIS   A ND1 1 
ATOM   1330 C CD2 . HIS   A 1 172 ? -14.26350 -17.58576 -11.66482 1.000 11.94470 ? 172 HIS   A CD2 1 
ATOM   1331 C CE1 . HIS   A 1 172 ? -16.00648 -18.58521 -10.77664 1.000 12.92986 ? 172 HIS   A CE1 1 
ATOM   1332 N NE2 . HIS   A 1 172 ? -15.50971 -18.11557 -11.91098 1.000 10.47377 ? 172 HIS   A NE2 1 
ATOM   1333 N N   . ALA   A 1 173 ? -9.63444  -17.02352 -9.67482  1.000 9.54288  ? 173 ALA   A N   1 
ATOM   1334 C CA  . ALA   A 1 173 ? -8.36965  -16.65007 -9.07098  1.000 7.40339  ? 173 ALA   A CA  1 
ATOM   1335 C C   . ALA   A 1 173 ? -8.26400  -15.13949 -9.17167  1.000 7.86756  ? 173 ALA   A C   1 
ATOM   1336 O O   . ALA   A 1 173 ? -8.84178  -14.53664 -10.07886 1.000 6.80034  ? 173 ALA   A O   1 
ATOM   1337 C CB  . ALA   A 1 173 ? -7.21078  -17.39314 -9.78013  1.000 11.19874 ? 173 ALA   A CB  1 
ATOM   1338 N N   . GLY   A 1 174 ? -7.58249  -14.52019 -8.22400  1.000 6.96407  ? 174 GLY   A N   1 
ATOM   1339 C CA  . GLY   A 1 174 ? -7.46937  -13.08096 -8.24855  1.000 6.71654  ? 174 GLY   A CA  1 
ATOM   1340 C C   . GLY   A 1 174 ? -6.40463  -12.62830 -7.30182  1.000 7.96602  ? 174 GLY   A C   1 
ATOM   1341 O O   . GLY   A 1 174 ? -5.56664  -13.42034 -6.87701  1.000 5.96525  ? 174 GLY   A O   1 
ATOM   1342 N N   . THR   A 1 175 ? -6.48619  -11.35648 -6.90446  1.000 6.41753  ? 175 THR   A N   1 
ATOM   1343 C CA  . THR   A 1 175 ? -5.40126  -10.74094 -6.16818  1.000 5.66145  ? 175 THR   A CA  1 
ATOM   1344 C C   . THR   A 1 175 ? -5.98001  -10.12800 -4.90521  1.000 8.45260  ? 175 THR   A C   1 
ATOM   1345 O O   . THR   A 1 175 ? -7.20326  -9.97522  -4.77655  1.000 3.72560  ? 175 THR   A O   1 
ATOM   1346 C CB  . THR   A 1 175 ? -4.65821  -9.64307  -6.98163  1.000 8.87534  ? 175 THR   A CB  1 
ATOM   1347 O OG1 . THR   A 1 175 ? -5.50136  -8.47889  -7.20016  1.000 8.36057  ? 175 THR   A OG1 1 
ATOM   1348 C CG2 . THR   A 1 175 ? -4.07233  -10.19896 -8.30218  1.000 7.56984  ? 175 THR   A CG2 1 
ATOM   1349 N N   . ASP   A 1 176 ? -5.07744  -9.78824  -3.98502  1.000 9.30527  ? 176 ASP   A N   1 
ATOM   1350 C CA  . ASP   A 1 176 ? -5.39296  -8.84200  -2.93545  1.000 7.46818  ? 176 ASP   A CA  1 
ATOM   1351 C C   . ASP   A 1 176 ? -5.38875  -7.45581  -3.56770  1.000 5.57305  ? 176 ASP   A C   1 
ATOM   1352 O O   . ASP   A 1 176 ? -5.11654  -7.30545  -4.76696  1.000 8.31145  ? 176 ASP   A O   1 
ATOM   1353 C CB  . ASP   A 1 176 ? -4.44608  -8.98739  -1.69346  1.000 7.97357  ? 176 ASP   A CB  1 
ATOM   1354 C CG  . ASP   A 1 176 ? -2.97828  -8.71777  -1.96905  1.000 12.73356 ? 176 ASP   A CG  1 
ATOM   1355 O OD1 . ASP   A 1 176 ? -2.69419  -7.93657  -2.87540  1.000 6.96546  ? 176 ASP   A OD1 1 
ATOM   1356 O OD2 . ASP   A 1 176 ? -2.09306  -9.26490  -1.23218  1.000 10.78955 ? 176 ASP   A OD2 1 
ATOM   1357 N N   . LEU   A 1 177 ? -5.77500  -6.45044  -2.77268  1.000 7.11109  ? 177 LEU   A N   1 
ATOM   1358 C CA  . LEU   A 1 177 ? -5.93743  -5.09592  -3.29108  1.000 7.93136  ? 177 LEU   A CA  1 
ATOM   1359 C C   . LEU   A 1 177 ? -4.60058  -4.37991  -3.46432  1.000 13.66754 ? 177 LEU   A C   1 
ATOM   1360 O O   . LEU   A 1 177 ? -4.58513  -3.27350  -4.01803  1.000 10.25170 ? 177 LEU   A O   1 
ATOM   1361 C CB  . LEU   A 1 177 ? -6.91668  -4.29289  -2.40424  1.000 7.70094  ? 177 LEU   A CB  1 
ATOM   1362 C CG  . LEU   A 1 177 ? -8.40211  -4.36550  -2.88734  1.000 9.22208  ? 177 LEU   A CG  1 
ATOM   1363 C CD1 . LEU   A 1 177 ? -8.55831  -3.68358  -4.28516  1.000 6.98242  ? 177 LEU   A CD1 1 
ATOM   1364 C CD2 . LEU   A 1 177 ? -8.95281  -5.82047  -2.94979  1.000 11.02490 ? 177 LEU   A CD2 1 
ATOM   1365 N N   . GLU   A 1 178 ? -3.47888  -4.99187  -3.06379  1.000 10.33328 ? 178 GLU   A N   1 
ATOM   1366 C CA  . GLU   A 1 178 ? -2.17734  -4.46914  -3.49792  1.000 11.91003 ? 178 GLU   A CA  1 
ATOM   1367 C C   . GLU   A 1 178 ? -1.67785  -5.16188  -4.74938  1.000 10.17285 ? 178 GLU   A C   1 
ATOM   1368 O O   . GLU   A 1 178 ? -0.53066  -4.95258  -5.13106  1.000 11.58250 ? 178 GLU   A O   1 
ATOM   1369 C CB  . GLU   A 1 178 ? -1.09691  -4.61585  -2.42411  1.000 13.85559 ? 178 GLU   A CB  1 
ATOM   1370 C CG  . GLU   A 1 178 ? -1.55482  -4.26835  -1.04648  1.000 14.20308 ? 178 GLU   A CG  1 
ATOM   1371 C CD  . GLU   A 1 178 ? -1.51161  -2.82453  -0.71921  1.000 19.64122 ? 178 GLU   A CD  1 
ATOM   1372 O OE1 . GLU   A 1 178 ? -1.78795  -2.52141  0.47149   1.000 31.63693 ? 178 GLU   A OE1 1 
ATOM   1373 O OE2 . GLU   A 1 178 ? -1.25913  -2.01513  -1.62894  1.000 20.40719 ? 178 GLU   A OE2 1 
ATOM   1374 N N   . GLY   A 1 179 ? -2.49714  -6.00811  -5.37274  1.000 10.02848 ? 179 GLY   A N   1 
ATOM   1375 C CA  . GLY   A 1 179 ? -2.16818  -6.57849  -6.66687  1.000 9.75762  ? 179 GLY   A CA  1 
ATOM   1376 C C   . GLY   A 1 179 ? -1.40040  -7.88229  -6.63311  1.000 8.82206  ? 179 GLY   A C   1 
ATOM   1377 O O   . GLY   A 1 179 ? -0.92038  -8.32494  -7.68568  1.000 8.77343  ? 179 GLY   A O   1 
ATOM   1378 N N   . ASN   A 1 180 ? -1.27451  -8.52119  -5.47646  1.000 6.93696  ? 180 ASN   A N   1 
ATOM   1379 C CA  . ASN   A 1 180 ? -0.49525  -9.74379  -5.37787  1.000 8.44719  ? 180 ASN   A CA  1 
ATOM   1380 C C   . ASN   A 1 180 ? -1.45611  -10.90599 -5.46859  1.000 6.24715  ? 180 ASN   A C   1 
ATOM   1381 O O   . ASN   A 1 180 ? -2.39165  -10.97053 -4.68149  1.000 6.10208  ? 180 ASN   A O   1 
ATOM   1382 C CB  . ASN   A 1 180 ? 0.31012   -9.74767  -4.06168  1.000 7.86662  ? 180 ASN   A CB  1 
ATOM   1383 C CG  . ASN   A 1 180 ? 1.23748   -8.56449  -4.00805  1.000 11.17347 ? 180 ASN   A CG  1 
ATOM   1384 O OD1 . ASN   A 1 180 ? 2.05040   -8.44364  -4.88847  1.000 9.60962  ? 180 ASN   A OD1 1 
ATOM   1385 N ND2 . ASN   A 1 180 ? 1.03813   -7.61845  -3.05784  1.000 9.66019  ? 180 ASN   A ND2 1 
ATOM   1386 N N   . PHE   A 1 181 ? -1.24915  -11.80242 -6.44566  1.000 7.81200  ? 181 PHE   A N   1 
ATOM   1387 C CA  . PHE   A 1 181 ? -2.14598  -12.93685 -6.58983  1.000 8.61772  ? 181 PHE   A CA  1 
ATOM   1388 C C   . PHE   A 1 181 ? -2.19268  -13.79296 -5.33567  1.000 6.39483  ? 181 PHE   A C   1 
ATOM   1389 O O   . PHE   A 1 181 ? -1.17790  -14.00449 -4.65346  1.000 5.96040  ? 181 PHE   A O   1 
ATOM   1390 C CB  . PHE   A 1 181 ? -1.74229  -13.83651 -7.78073  1.000 10.47996 ? 181 PHE   A CB  1 
ATOM   1391 C CG  . PHE   A 1 181 ? -2.49546  -13.53092 -9.04454  1.000 9.77497  ? 181 PHE   A CG  1 
ATOM   1392 C CD1 . PHE   A 1 181 ? -3.73091  -14.13985 -9.28354  1.000 11.32348 ? 181 PHE   A CD1 1 
ATOM   1393 C CD2 . PHE   A 1 181 ? -2.00273  -12.63112 -9.98605  1.000 7.93756  ? 181 PHE   A CD2 1 
ATOM   1394 C CE1 . PHE   A 1 181 ? -4.47738  -13.84700 -10.46144 1.000 8.34300  ? 181 PHE   A CE1 1 
ATOM   1395 C CE2 . PHE   A 1 181 ? -2.71691  -12.36213 -11.17340 1.000 10.37628 ? 181 PHE   A CE2 1 
ATOM   1396 C CZ  . PHE   A 1 181 ? -3.96420  -12.96592 -11.39710 1.000 9.78369  ? 181 PHE   A CZ  1 
ATOM   1397 N N   . TYR   A 1 182 ? -3.38484  -14.32913 -5.08793  1.000 7.47265  ? 182 TYR   A N   1 
ATOM   1398 C CA  . TYR   A 1 182 ? -3.56053  -15.49554 -4.23736  1.000 6.39179  ? 182 TYR   A CA  1 
ATOM   1399 C C   . TYR   A 1 182 ? -3.16077  -16.72440 -5.03322  1.000 8.61777  ? 182 TYR   A C   1 
ATOM   1400 O O   . TYR   A 1 182 ? -3.71765  -16.99429 -6.10915  1.000 9.38579  ? 182 TYR   A O   1 
ATOM   1401 C CB  . TYR   A 1 182 ? -5.00052  -15.57542 -3.76660  1.000 6.22759  ? 182 TYR   A CB  1 
ATOM   1402 C CG  . TYR   A 1 182 ? -5.38685  -14.49606 -2.75641  1.000 5.37336  ? 182 TYR   A CG  1 
ATOM   1403 C CD1 . TYR   A 1 182 ? -5.09213  -14.66143 -1.40095  1.000 8.74275  ? 182 TYR   A CD1 1 
ATOM   1404 C CD2 . TYR   A 1 182 ? -6.06208  -13.32899 -3.15419  1.000 5.06219  ? 182 TYR   A CD2 1 
ATOM   1405 C CE1 . TYR   A 1 182 ? -5.48922  -13.68926 -0.44936  1.000 9.61860  ? 182 TYR   A CE1 1 
ATOM   1406 C CE2 . TYR   A 1 182 ? -6.47559  -12.34828 -2.19566  1.000 3.50511  ? 182 TYR   A CE2 1 
ATOM   1407 C CZ  . TYR   A 1 182 ? -6.18394  -12.55627 -0.84888  1.000 5.42325  ? 182 TYR   A CZ  1 
ATOM   1408 O OH  . TYR   A 1 182 ? -6.52106  -11.64879 0.14863   1.000 4.83180  ? 182 TYR   A OH  1 
ATOM   1409 N N   . GLY   A 1 183 ? -2.15198  -17.41636 -4.55846  1.000 7.76379  ? 183 GLY   A N   1 
ATOM   1410 C CA  . GLY   A 1 183 ? -1.77023  -18.66526 -5.17727  1.000 7.90887  ? 183 GLY   A CA  1 
ATOM   1411 C C   . GLY   A 1 183 ? -0.86766  -18.47629 -6.38398  1.000 11.72319 ? 183 GLY   A C   1 
ATOM   1412 O O   . GLY   A 1 183 ? -0.45677  -17.37089 -6.72158  1.000 8.89996  ? 183 GLY   A O   1 
ATOM   1413 N N   . PRO   A 1 184 ? -0.53166  -19.55661 -7.02458  1.000 11.04324 ? 184 PRO   A N   1 
ATOM   1414 C CA  . PRO   A 1 184 ? 0.47490   -19.52117 -8.09415  1.000 12.27415 ? 184 PRO   A CA  1 
ATOM   1415 C C   . PRO   A 1 184 ? -0.16130  -19.33254 -9.44920  1.000 16.80057 ? 184 PRO   A C   1 
ATOM   1416 O O   . PRO   A 1 184 ? 0.08276   -20.10722 -10.38819 1.000 19.53228 ? 184 PRO   A O   1 
ATOM   1417 C CB  . PRO   A 1 184 ? 1.06870   -20.94559 -8.03658  1.000 16.28864 ? 184 PRO   A CB  1 
ATOM   1418 C CG  . PRO   A 1 184 ? -0.18000  -21.76286 -7.66198  1.000 15.53485 ? 184 PRO   A CG  1 
ATOM   1419 C CD  . PRO   A 1 184 ? -1.00002  -20.91042 -6.73649  1.000 12.33190 ? 184 PRO   A CD  1 
ATOM   1420 N N   . PHE   A 1 185 ? -0.85671  -18.21335 -9.62866  1.000 13.87476 ? 185 PHE   A N   1 
ATOM   1421 C CA  . PHE   A 1 185 ? -1.57506  -17.88992 -10.85854 1.000 14.37088 ? 185 PHE   A CA  1 
ATOM   1422 C C   . PHE   A 1 185 ? -1.02732  -16.56856 -11.39071 1.000 15.59897 ? 185 PHE   A C   1 
ATOM   1423 O O   . PHE   A 1 185 ? -0.55554  -15.72917 -10.62376 1.000 16.03828 ? 185 PHE   A O   1 
ATOM   1424 C CB  . PHE   A 1 185 ? -3.10370  -17.82802 -10.60380 1.000 13.68141 ? 185 PHE   A CB  1 
ATOM   1425 C CG  . PHE   A 1 185 ? -3.63843  -19.08022 -9.93675  1.000 13.02922 ? 185 PHE   A CG  1 
ATOM   1426 C CD1 . PHE   A 1 185 ? -3.61908  -20.27445 -10.61541 1.000 12.93092 ? 185 PHE   A CD1 1 
ATOM   1427 C CD2 . PHE   A 1 185 ? -4.07378  -19.08654 -8.62945  1.000 10.69552 ? 185 PHE   A CD2 1 
ATOM   1428 C CE1 . PHE   A 1 185 ? -4.05955  -21.44491 -10.02359 1.000 13.84167 ? 185 PHE   A CE1 1 
ATOM   1429 C CE2 . PHE   A 1 185 ? -4.52377  -20.26638 -8.04372  1.000 12.67988 ? 185 PHE   A CE2 1 
ATOM   1430 C CZ  . PHE   A 1 185 ? -4.49964  -21.44368 -8.75020  1.000 11.09607 ? 185 PHE   A CZ  1 
ATOM   1431 N N   . VAL   A 1 186 ? -1.05117  -16.40268 -12.71068 1.000 14.95561 ? 186 VAL   A N   1 
ATOM   1432 C CA  . VAL   A 1 186 ? -0.50782  -15.21525 -13.35846 1.000 15.30848 ? 186 VAL   A CA  1 
ATOM   1433 C C   . VAL   A 1 186 ? -1.55908  -14.66481 -14.30746 1.000 15.88993 ? 186 VAL   A C   1 
ATOM   1434 O O   . VAL   A 1 186 ? -2.37627  -15.40885 -14.85774 1.000 15.39343 ? 186 VAL   A O   1 
ATOM   1435 C CB  . VAL   A 1 186 ? 0.80431   -15.53307 -14.10523 1.000 16.98542 ? 186 VAL   A CB  1 
ATOM   1436 C CG1 . VAL   A 1 186 ? 1.93248   -15.86075 -13.09632 1.000 19.10245 ? 186 VAL   A CG1 1 
ATOM   1437 C CG2 . VAL   A 1 186 ? 0.57809   -16.71540 -15.04154 1.000 19.56376 ? 186 VAL   A CG2 1 
ATOM   1438 N N   . ASP   A 1 187 ? -1.54936  -13.34589 -14.48865 1.000 13.06044 ? 187 ASP   A N   1 
ATOM   1439 C CA  . ASP   A 1 187 ? -2.54726  -12.71489 -15.35393 1.000 14.44302 ? 187 ASP   A CA  1 
ATOM   1440 C C   . ASP   A 1 187 ? -2.05832  -12.77800 -16.79467 1.000 20.02617 ? 187 ASP   A C   1 
ATOM   1441 O O   . ASP   A 1 187 ? -1.73806  -11.77783 -17.44299 1.000 16.84142 ? 187 ASP   A O   1 
ATOM   1442 C CB  . ASP   A 1 187 ? -2.87592  -11.29992 -14.89493 1.000 12.67926 ? 187 ASP   A CB  1 
ATOM   1443 C CG  . ASP   A 1 187 ? -1.66163  -10.42359 -14.63901 1.000 13.39745 ? 187 ASP   A CG  1 
ATOM   1444 O OD1 . ASP   A 1 187 ? -0.49000  -10.87582 -14.63321 1.000 10.96334 ? 187 ASP   A OD1 1 
ATOM   1445 O OD2 . ASP   A 1 187 ? -1.93938  -9.23472  -14.34652 1.000 12.31341 ? 187 ASP   A OD2 1 
ATOM   1446 N N   . ARG   A 1 188 ? -1.97253  -14.00765 -17.28599 1.000 19.08530 ? 188 ARG   A N   1 
ATOM   1447 C CA  . ARG   A 1 188 ? -1.67132  -14.19855 -18.69053 1.000 28.76031 ? 188 ARG   A CA  1 
ATOM   1448 C C   . ARG   A 1 188 ? -2.38341  -15.49586 -19.07753 1.000 35.61800 ? 188 ARG   A C   1 
ATOM   1449 O O   . ARG   A 1 188 ? -2.73903  -16.28406 -18.20160 1.000 29.95396 ? 188 ARG   A O   1 
ATOM   1450 C CB  . ARG   A 1 188 ? -0.14198  -14.18930 -18.88201 1.000 29.64437 ? 188 ARG   A CB  1 
ATOM   1451 C CG  . ARG   A 1 188 ? 0.61876   -15.47599 -18.62781 1.000 35.22644 ? 188 ARG   A CG  1 
ATOM   1452 C CD  . ARG   A 1 188 ? 2.16742   -15.23484 -18.51445 1.000 37.82969 ? 188 ARG   A CD  1 
ATOM   1453 N NE  . ARG   A 1 188 ? 2.59994   -14.49337 -17.33250 1.000 38.41929 ? 188 ARG   A NE  1 
ATOM   1454 C CZ  . ARG   A 1 188 ? 3.49029   -14.99388 -16.47386 1.000 37.61895 ? 188 ARG   A CZ  1 
ATOM   1455 N NH1 . ARG   A 1 188 ? 3.82376   -14.37163 -15.33977 1.000 37.44951 ? 188 ARG   A NH1 1 
ATOM   1456 N NH2 . ARG   A 1 188 ? 4.20518   -16.02398 -16.88286 1.000 32.72869 ? 188 ARG   A NH2 1 
ATOM   1457 N N   . GLN   A 1 189 ? -2.65541  -15.72051 -20.36948 1.000 39.10529 ? 189 GLN   A N   1 
ATOM   1458 C CA  . GLN   A 1 189 ? -3.47300  -16.89521 -20.75302 1.000 42.65752 ? 189 GLN   A CA  1 
ATOM   1459 C C   . GLN   A 1 189 ? -2.61909  -18.12545 -21.05554 1.000 44.53933 ? 189 GLN   A C   1 
ATOM   1460 O O   . GLN   A 1 189 ? -2.27275  -18.38718 -22.21442 1.000 51.67485 ? 189 GLN   A O   1 
ATOM   1461 C CB  . GLN   A 1 189 ? -4.34730  -16.58469 -21.96053 1.000 48.91411 ? 189 GLN   A CB  1 
ATOM   1462 C CG  . GLN   A 1 189 ? -5.22637  -17.76701 -22.43609 1.000 52.68580 ? 189 GLN   A CG  1 
ATOM   1463 C CD  . GLN   A 1 189 ? -6.58416  -17.31445 -22.99577 1.000 57.22094 ? 189 GLN   A CD  1 
ATOM   1464 O OE1 . GLN   A 1 189 ? -6.87700  -16.10964 -23.04384 1.000 53.22338 ? 189 GLN   A OE1 1 
ATOM   1465 N NE2 . GLN   A 1 189 ? -7.41268  -18.28146 -23.43505 1.000 56.63842 ? 189 GLN   A NE2 1 
ATOM   1466 N N   . THR   A 1 190 ? -2.11688  -18.81170 -19.97354 1.000 38.93730 ? 190 THR   A N   1 
ATOM   1467 C CA  . THR   A 1 190 ? -1.36326  -20.07716 -20.00927 1.000 32.81833 ? 190 THR   A CA  1 
ATOM   1468 C C   . THR   A 1 190 ? -2.31354  -21.21694 -19.77320 1.000 32.69584 ? 190 THR   A C   1 
ATOM   1469 O O   . THR   A 1 190 ? -3.52052  -21.02247 -19.64068 1.000 33.56086 ? 190 THR   A O   1 
ATOM   1470 C CB  . THR   A 1 190 ? -0.20249  -20.15322 -18.97937 1.000 34.75423 ? 190 THR   A CB  1 
ATOM   1471 O OG1 . THR   A 1 190 ? -0.72162  -20.50944 -17.70422 1.000 35.42075 ? 190 THR   A OG1 1 
ATOM   1472 C CG2 . THR   A 1 190 ? 0.55215   -18.84020 -18.77196 1.000 34.08937 ? 190 THR   A CG2 1 
ATOM   1473 N N   . ALA   A 1 191 ? -1.75123  -22.41453 -19.67555 1.000 36.38162 ? 191 ALA   A N   1 
ATOM   1474 C CA  . ALA   A 1 191 ? -2.49445  -23.62505 -19.38549 1.000 34.93841 ? 191 ALA   A CA  1 
ATOM   1475 C C   . ALA   A 1 191 ? -2.65937  -23.85867 -17.89408 1.000 33.47151 ? 191 ALA   A C   1 
ATOM   1476 O O   . ALA   A 1 191 ? -2.92061  -24.99581 -17.48505 1.000 34.30897 ? 191 ALA   A O   1 
ATOM   1477 C CB  . ALA   A 1 191 ? -1.80005  -24.82875 -20.02897 1.000 31.58729 ? 191 ALA   A CB  1 
ATOM   1478 N N   . GLN   A 1 192 ? -2.52386  -22.81423 -17.08115 1.000 30.64046 ? 192 GLN   A N   1 
ATOM   1479 C CA  . GLN   A 1 192 ? -2.54563  -22.95882 -15.63079 1.000 28.93201 ? 192 GLN   A CA  1 
ATOM   1480 C C   . GLN   A 1 192 ? -3.84256  -23.59167 -15.12769 1.000 31.58483 ? 192 GLN   A C   1 
ATOM   1481 O O   . GLN   A 1 192 ? -4.92426  -23.40825 -15.69447 1.000 25.52730 ? 192 GLN   A O   1 
ATOM   1482 C CB  . GLN   A 1 192 ? -2.28230  -21.59380 -14.97722 1.000 28.50715 ? 192 GLN   A CB  1 
ATOM   1483 C CG  . GLN   A 1 192 ? -3.12017  -20.48076 -15.51978 1.000 25.59339 ? 192 GLN   A CG  1 
ATOM   1484 C CD  . GLN   A 1 192 ? -2.76970  -19.10194 -14.94427 1.000 26.18903 ? 192 GLN   A CD  1 
ATOM   1485 O OE1 . GLN   A 1 192 ? -2.06403  -18.96702 -13.93017 1.000 21.13723 ? 192 GLN   A OE1 1 
ATOM   1486 N NE2 . GLN   A 1 192 ? -3.14813  -18.06737 -15.68871 1.000 23.18887 ? 192 GLN   A NE2 1 
ATOM   1487 N N   . ALA   A 1 193 ? -3.71015  -24.36343 -14.04703 1.000 24.28191 ? 193 ALA   A N   1 
ATOM   1488 C CA  . ALA   A 1 193 ? -4.81155  -25.13151 -13.48707 1.000 23.35415 ? 193 ALA   A CA  1 
ATOM   1489 C C   . ALA   A 1 193 ? -4.76150  -25.03989 -11.96598 1.000 23.14090 ? 193 ALA   A C   1 
ATOM   1490 O O   . ALA   A 1 193 ? -3.71096  -24.76833 -11.38376 1.000 23.36293 ? 193 ALA   A O   1 
ATOM   1491 C CB  . ALA   A 1 193 ? -4.74225  -26.59470 -13.92741 1.000 26.22496 ? 193 ALA   A CB  1 
ATOM   1492 N N   . ALA   A 1 194 ? -5.90313  -25.33391 -11.32928 1.000 23.57978 ? 194 ALA   A N   1 
ATOM   1493 C CA  . ALA   A 1 194 ? -6.05950  -25.11401 -9.89074  1.000 21.22749 ? 194 ALA   A CA  1 
ATOM   1494 C C   . ALA   A 1 194 ? -5.02334  -25.86443 -9.05110  1.000 27.84545 ? 194 ALA   A C   1 
ATOM   1495 O O   . ALA   A 1 194 ? -4.43314  -25.29098 -8.13382  1.000 32.08597 ? 194 ALA   A O   1 
ATOM   1496 C CB  . ALA   A 1 194 ? -7.47033  -25.50376 -9.44717  1.000 19.46537 ? 194 ALA   A CB  1 
ATOM   1497 N N   . GLY   A 1 195 ? -4.83352  -27.15426 -9.26640  1.000 26.18707 ? 195 GLY   A N   1 
ATOM   1498 C CA  . GLY   A 1 195 ? -4.03666  -27.82730 -8.25140  1.000 29.16238 ? 195 GLY   A CA  1 
ATOM   1499 C C   . GLY   A 1 195 ? -4.88615  -28.38804 -7.11350  1.000 30.37125 ? 195 GLY   A C   1 
ATOM   1500 O O   . GLY   A 1 195 ? -6.01507  -27.97018 -6.87163  1.000 23.74858 ? 195 GLY   A O   1 
ATOM   1501 N N   . THR   A 1 196 ? -4.33423  -29.37577 -6.40869  1.000 27.84740 ? 196 THR   A N   1 
ATOM   1502 C CA  . THR   A 1 196 ? -5.18262  -30.20593 -5.55756  1.000 28.80572 ? 196 THR   A CA  1 
ATOM   1503 C C   . THR   A 1 196 ? -5.63299  -29.45326 -4.30145  1.000 19.63385 ? 196 THR   A C   1 
ATOM   1504 O O   . THR   A 1 196 ? -4.86239  -28.71904 -3.67589  1.000 22.42005 ? 196 THR   A O   1 
ATOM   1505 C CB  . THR   A 1 196 ? -4.46168  -31.49997 -5.17055  1.000 29.32737 ? 196 THR   A CB  1 
ATOM   1506 O OG1 . THR   A 1 196 ? -3.35296  -31.16862 -4.33206  1.000 32.54910 ? 196 THR   A OG1 1 
ATOM   1507 C CG2 . THR   A 1 196 ? -3.96959  -32.29825 -6.44009  1.000 27.11787 ? 196 THR   A CG2 1 
ATOM   1508 N N   . ASP   A 1 197 ? -6.90241  -29.61612 -3.95649  1.000 20.98742 ? 197 ASP   A N   1 
ATOM   1509 C CA  . ASP   A 1 197 ? -7.50312  -28.94868 -2.80349  1.000 16.62021 ? 197 ASP   A CA  1 
ATOM   1510 C C   . ASP   A 1 197 ? -7.67426  -29.91567 -1.63943  1.000 22.15380 ? 197 ASP   A C   1 
ATOM   1511 O O   . ASP   A 1 197 ? -7.60578  -31.13649 -1.80079  1.000 23.39828 ? 197 ASP   A O   1 
ATOM   1512 C CB  . ASP   A 1 197 ? -8.86134  -28.36646 -3.16719  1.000 15.78711 ? 197 ASP   A CB  1 
ATOM   1513 C CG  . ASP   A 1 197 ? -9.18587  -27.09010 -2.39454  1.000 15.34858 ? 197 ASP   A CG  1 
ATOM   1514 O OD1 . ASP   A 1 197 ? -8.30424  -26.47194 -1.74097  1.000 16.41668 ? 197 ASP   A OD1 1 
ATOM   1515 O OD2 . ASP   A 1 197 ? -10.34697 -26.68521 -2.49875  1.000 17.27997 ? 197 ASP   A OD2 1 
ATOM   1516 N N   . THR   A 1 198 ? -7.91749  -29.34564 -0.45937  1.000 15.13111 ? 198 THR   A N   1 
ATOM   1517 C CA  . THR   A 1 198 ? -8.23825  -30.10645 0.74238   1.000 16.99904 ? 198 THR   A CA  1 
ATOM   1518 C C   . THR   A 1 198 ? -9.49641  -29.52965 1.38000   1.000 19.51678 ? 198 THR   A C   1 
ATOM   1519 O O   . THR   A 1 198 ? -9.90637  -28.41005 1.06812   1.000 16.03898 ? 198 THR   A O   1 
ATOM   1520 C CB  . THR   A 1 198 ? -7.07518  -30.08784 1.75391   1.000 21.10608 ? 198 THR   A CB  1 
ATOM   1521 O OG1 . THR   A 1 198 ? -6.60019  -28.74020 1.95085   1.000 19.54452 ? 198 THR   A OG1 1 
ATOM   1522 C CG2 . THR   A 1 198 ? -5.94081  -30.90892 1.22169   1.000 24.88503 ? 198 THR   A CG2 1 
ATOM   1523 N N   . THR   A 1 199 ? -10.12170 -30.30165 2.27317   1.000 16.89684 ? 199 THR   A N   1 
ATOM   1524 C CA  . THR   A 1 199 ? -11.24169 -29.76929 3.04674   1.000 16.80160 ? 199 THR   A CA  1 
ATOM   1525 C C   . THR   A 1 199 ? -10.75929 -29.03212 4.29777   1.000 15.50587 ? 199 THR   A C   1 
ATOM   1526 O O   . THR   A 1 199 ? -9.80955  -29.45496 4.96312   1.000 16.01924 ? 199 THR   A O   1 
ATOM   1527 C CB  . THR   A 1 199 ? -12.21054 -30.89191 3.42593   1.000 17.82481 ? 199 THR   A CB  1 
ATOM   1528 O OG1 . THR   A 1 199 ? -12.72665 -31.46832 2.22877   1.000 14.78569 ? 199 THR   A OG1 1 
ATOM   1529 C CG2 . THR   A 1 199 ? -13.38577 -30.33278 4.16357   1.000 16.19838 ? 199 THR   A CG2 1 
ATOM   1530 N N   . ILE   A 1 200 ? -11.41744 -27.91595 4.62045   1.000 13.78517 ? 200 ILE   A N   1 
ATOM   1531 C CA  . ILE   A 1 200 ? -10.97753 -27.05560 5.72506   1.000 13.41372 ? 200 ILE   A CA  1 
ATOM   1532 C C   . ILE   A 1 200 ? -11.56931 -27.59221 7.02991   1.000 15.37409 ? 200 ILE   A C   1 
ATOM   1533 O O   . ILE   A 1 200 ? -12.68065 -27.23120 7.42025   1.000 11.14783 ? 200 ILE   A O   1 
ATOM   1534 C CB  . ILE   A 1 200 ? -11.35264 -25.58687 5.50550   1.000 14.77923 ? 200 ILE   A CB  1 
ATOM   1535 C CG1 . ILE   A 1 200 ? -10.90928 -25.08848 4.11874   1.000 12.93537 ? 200 ILE   A CG1 1 
ATOM   1536 C CG2 . ILE   A 1 200 ? -10.75730 -24.69711 6.62620   1.000 12.90847 ? 200 ILE   A CG2 1 
ATOM   1537 C CD1 . ILE   A 1 200 ? -11.81329 -23.91002 3.58867   1.000 13.04182 ? 200 ILE   A CD1 1 
ATOM   1538 N N   . THR   A 1 201 ? -10.78426 -28.40397 7.74691   1.000 14.21467 ? 201 THR   A N   1 
ATOM   1539 C CA  . THR   A 1 201 ? -11.29391 -29.18470 8.88231   1.000 11.99252 ? 201 THR   A CA  1 
ATOM   1540 C C   . THR   A 1 201 ? -11.90426 -28.30138 9.95134   1.000 13.63045 ? 201 THR   A C   1 
ATOM   1541 O O   . THR   A 1 201 ? -13.00986 -28.57502 10.43846  1.000 13.64245 ? 201 THR   A O   1 
ATOM   1542 C CB  . THR   A 1 201 ? -10.14157 -29.99667 9.46329   1.000 13.79481 ? 201 THR   A CB  1 
ATOM   1543 O OG1 . THR   A 1 201 ? -9.57887  -30.72305 8.37048   1.000 13.56595 ? 201 THR   A OG1 1 
ATOM   1544 C CG2 . THR   A 1 201 ? -10.62791 -30.96761 10.57400  1.000 15.85026 ? 201 THR   A CG2 1 
ATOM   1545 N N   . VAL   A 1 202 ? -11.19592 -27.24192 10.35428  1.000 9.26645  ? 202 VAL   A N   1 
ATOM   1546 C CA  . VAL   A 1 202 ? -11.72931 -26.46593 11.46964  1.000 9.18715  ? 202 VAL   A CA  1 
ATOM   1547 C C   . VAL   A 1 202 ? -13.09218 -25.88295 11.10357  1.000 8.73895  ? 202 VAL   A C   1 
ATOM   1548 O O   . VAL   A 1 202 ? -13.96630 -25.71652 11.96969  1.000 9.00672  ? 202 VAL   A O   1 
ATOM   1549 C CB  . VAL   A 1 202 ? -10.74425 -25.37325 11.91472  1.000 10.64256 ? 202 VAL   A CB  1 
ATOM   1550 C CG1 . VAL   A 1 202 ? -10.44604 -24.37094 10.75040  1.000 12.19436 ? 202 VAL   A CG1 1 
ATOM   1551 C CG2 . VAL   A 1 202 ? -11.29502 -24.64165 13.14131  1.000 12.15149 ? 202 VAL   A CG2 1 
ATOM   1552 N N   . ASN   A 1 203 ? -13.29650 -25.55854 9.82944   1.000 9.50532  ? 203 ASN   A N   1 
ATOM   1553 C CA  . ASN   A 1 203 ? -14.57586 -24.98365 9.42121   1.000 9.28118  ? 203 ASN   A CA  1 
ATOM   1554 C C   . ASN   A 1 203 ? -15.69065 -26.02076 9.50953   1.000 10.34806 ? 203 ASN   A C   1 
ATOM   1555 O O   . ASN   A 1 203 ? -16.81530 -25.69876 9.92607   1.000 10.98428 ? 203 ASN   A O   1 
ATOM   1556 C CB  . ASN   A 1 203 ? -14.47045 -24.42779 8.00225   1.000 10.78604 ? 203 ASN   A CB  1 
ATOM   1557 C CG  . ASN   A 1 203 ? -13.73096 -23.10908 7.95237   1.000 8.23830  ? 203 ASN   A CG  1 
ATOM   1558 O OD1 . ASN   A 1 203 ? -13.20431 -22.62797 8.97249   1.000 8.33245  ? 203 ASN   A OD1 1 
ATOM   1559 N ND2 . ASN   A 1 203 ? -13.69357 -22.51034 6.77550   1.000 5.95918  ? 203 ASN   A ND2 1 
ATOM   1560 N N   . VAL   A 1 204 ? -15.41088 -27.26197 9.10369   1.000 7.82216  ? 204 VAL   A N   1 
ATOM   1561 C CA  . VAL   A 1 204 ? -16.41710 -28.31768 9.21350   1.000 12.22236 ? 204 VAL   A CA  1 
ATOM   1562 C C   . VAL   A 1 204 ? -16.86238 -28.46390 10.66214  1.000 10.55653 ? 204 VAL   A C   1 
ATOM   1563 O O   . VAL   A 1 204 ? -18.06317 -28.56248 10.95024  1.000 10.58659 ? 204 VAL   A O   1 
ATOM   1564 C CB  . VAL   A 1 204 ? -15.89006 -29.64884 8.64570   1.000 11.59089 ? 204 VAL   A CB  1 
ATOM   1565 C CG1 . VAL   A 1 204 ? -16.93027 -30.79670 8.86281   1.000 13.72133 ? 204 VAL   A CG1 1 
ATOM   1566 C CG2 . VAL   A 1 204 ? -15.56774 -29.49197 7.13872   1.000 9.78713  ? 204 VAL   A CG2 1 
ATOM   1567 N N   . LEU   A 1 205 ? -15.89434 -28.48594 11.58864  1.000 9.70831  ? 205 LEU   A N   1 
ATOM   1568 C CA  . LEU   A 1 205 ? -16.21209 -28.61460 13.01318  1.000 11.77930 ? 205 LEU   A CA  1 
ATOM   1569 C C   . LEU   A 1 205 ? -17.02726 -27.42865 13.47033  1.000 10.42594 ? 205 LEU   A C   1 
ATOM   1570 O O   . LEU   A 1 205 ? -17.98143 -27.58355 14.23722  1.000 13.36367 ? 205 LEU   A O   1 
ATOM   1571 C CB  . LEU   A 1 205 ? -14.93144 -28.71444 13.85916  1.000 9.37631  ? 205 LEU   A CB  1 
ATOM   1572 C CG  . LEU   A 1 205 ? -14.15949 -30.01770 13.64785  1.000 10.24850 ? 205 LEU   A CG  1 
ATOM   1573 C CD1 . LEU   A 1 205 ? -12.72049 -29.95103 14.27654  1.000 11.89946 ? 205 LEU   A CD1 1 
ATOM   1574 C CD2 . LEU   A 1 205 ? -14.98937 -31.21734 14.17185  1.000 13.28536 ? 205 LEU   A CD2 1 
ATOM   1575 N N   . ALA   A 1 206 ? -16.68725 -26.23020 12.97919  1.000 9.28997  ? 206 ALA   A N   1 
ATOM   1576 C CA  . ALA   A 1 206 ? -17.49347 -25.08639 13.36744  1.000 8.98972  ? 206 ALA   A CA  1 
ATOM   1577 C C   . ALA   A 1 206 ? -18.93515 -25.26417 12.92230  1.000 9.52241  ? 206 ALA   A C   1 
ATOM   1578 O O   . ALA   A 1 206 ? -19.85521 -24.93632 13.67220  1.000 11.55770 ? 206 ALA   A O   1 
ATOM   1579 C CB  . ALA   A 1 206 ? -16.95146 -23.78675 12.79353  1.000 8.62447  ? 206 ALA   A CB  1 
ATOM   1580 N N   . TRP   A 1 207 ? -19.13546 -25.74022 11.68808  1.000 9.03925  ? 207 TRP   A N   1 
ATOM   1581 C CA  . TRP   A 1 207 ? -20.46447 -25.91560 11.10311  1.000 11.42470 ? 207 TRP   A CA  1 
ATOM   1582 C C   . TRP   A 1 207 ? -21.25134 -27.01563 11.82304  1.000 12.66553 ? 207 TRP   A C   1 
ATOM   1583 O O   . TRP   A 1 207 ? -22.47968 -26.91799 11.98088  1.000 12.02056 ? 207 TRP   A O   1 
ATOM   1584 C CB  . TRP   A 1 207 ? -20.29510 -26.21386 9.61102   1.000 10.92677 ? 207 TRP   A CB  1 
ATOM   1585 C CG  . TRP   A 1 207 ? -21.52828 -26.65999 8.84962   1.000 11.93886 ? 207 TRP   A CG  1 
ATOM   1586 C CD1 . TRP   A 1 207 ? -22.54388 -25.86913 8.34383   1.000 12.71995 ? 207 TRP   A CD1 1 
ATOM   1587 C CD2 . TRP   A 1 207 ? -21.82106 -27.99033 8.45386   1.000 12.10578 ? 207 TRP   A CD2 1 
ATOM   1588 N NE1 . TRP   A 1 207 ? -23.48433 -26.66394 7.69918   1.000 13.43730 ? 207 TRP   A NE1 1 
ATOM   1589 C CE2 . TRP   A 1 207 ? -23.04282 -27.96350 7.73009   1.000 12.10688 ? 207 TRP   A CE2 1 
ATOM   1590 C CE3 . TRP   A 1 207 ? -21.17246 -29.21774 8.64825   1.000 13.48529 ? 207 TRP   A CE3 1 
ATOM   1591 C CZ2 . TRP   A 1 207 ? -23.62267 -29.11769 7.21756   1.000 16.70840 ? 207 TRP   A CZ2 1 
ATOM   1592 C CZ3 . TRP   A 1 207 ? -21.74837 -30.36468 8.12123   1.000 15.06990 ? 207 TRP   A CZ3 1 
ATOM   1593 C CH2 . TRP   A 1 207 ? -22.96270 -30.30976 7.42745   1.000 13.46705 ? 207 TRP   A CH2 1 
ATOM   1594 N N   . LEU   A 1 208 ? -20.56469 -28.07374 12.26037  1.000 10.07102 ? 208 LEU   A N   1 
ATOM   1595 C CA  . LEU   A 1 208 ? -21.20436 -29.05974 13.13692  1.000 11.88378 ? 208 LEU   A CA  1 
ATOM   1596 C C   . LEU   A 1 208 ? -21.69853 -28.41209 14.43259  1.000 12.78161 ? 208 LEU   A C   1 
ATOM   1597 O O   . LEU   A 1 208 ? -22.82231 -28.69570 14.89256  1.000 14.24265 ? 208 LEU   A O   1 
ATOM   1598 C CB  . LEU   A 1 208 ? -20.23085 -30.20543 13.41490  1.000 14.07076 ? 208 LEU   A CB  1 
ATOM   1599 C CG  . LEU   A 1 208 ? -19.96232 -31.15400 12.22486  1.000 14.00397 ? 208 LEU   A CG  1 
ATOM   1600 C CD1 . LEU   A 1 208 ? -18.94984 -32.21396 12.60182  1.000 15.14452 ? 208 LEU   A CD1 1 
ATOM   1601 C CD2 . LEU   A 1 208 ? -21.24213 -31.83558 11.70674  1.000 15.10728 ? 208 LEU   A CD2 1 
ATOM   1602 N N   . TYR   A 1 209 ? -20.90801 -27.50110 15.01801  1.000 13.49165 ? 209 TYR   A N   1 
ATOM   1603 C CA  . TYR   A 1 209 ? -21.39966 -26.75274 16.18224  1.000 13.24539 ? 209 TYR   A CA  1 
ATOM   1604 C C   . TYR   A 1 209 ? -22.61378 -25.89011 15.83599  1.000 16.94270 ? 209 TYR   A C   1 
ATOM   1605 O O   . TYR   A 1 209 ? -23.54976 -25.77736 16.63759  1.000 13.11885 ? 209 TYR   A O   1 
ATOM   1606 C CB  . TYR   A 1 209 ? -20.30491 -25.87408 16.77097  1.000 11.89895 ? 209 TYR   A CB  1 
ATOM   1607 C CG  . TYR   A 1 209 ? -19.36722 -26.64304 17.67743  1.000 15.74327 ? 209 TYR   A CG  1 
ATOM   1608 C CD1 . TYR   A 1 209 ? -19.79417 -27.12907 18.92165  1.000 18.71567 ? 209 TYR   A CD1 1 
ATOM   1609 C CD2 . TYR   A 1 209 ? -18.04758 -26.89900 17.28728  1.000 15.68937 ? 209 TYR   A CD2 1 
ATOM   1610 C CE1 . TYR   A 1 209 ? -18.89745 -27.84991 19.76822  1.000 18.06343 ? 209 TYR   A CE1 1 
ATOM   1611 C CE2 . TYR   A 1 209 ? -17.15608 -27.62024 18.11815  1.000 18.85979 ? 209 TYR   A CE2 1 
ATOM   1612 C CZ  . TYR   A 1 209 ? -17.58829 -28.09293 19.34251  1.000 18.05363 ? 209 TYR   A CZ  1 
ATOM   1613 O OH  . TYR   A 1 209 ? -16.69105 -28.80438 20.13365  1.000 20.77326 ? 209 TYR   A OH  1 
ATOM   1614 N N   . ALA   A 1 210 ? -22.59327 -25.21319 14.68132  1.000 12.84512 ? 210 ALA   A N   1 
ATOM   1615 C CA  . ALA   A 1 210 ? -23.79717 -24.49995 14.24743  1.000 11.01924 ? 210 ALA   A CA  1 
ATOM   1616 C C   . ALA   A 1 210 ? -25.00710 -25.42760 14.16802  1.000 13.90011 ? 210 ALA   A C   1 
ATOM   1617 O O   . ALA   A 1 210 ? -26.13548 -25.01292 14.44336  1.000 17.40462 ? 210 ALA   A O   1 
ATOM   1618 C CB  . ALA   A 1 210 ? -23.57410 -23.86213 12.87439  1.000 12.08599 ? 210 ALA   A CB  1 
ATOM   1619 N N   . ALA   A 1 211 ? -24.79902 -26.66424 13.70995  1.000 14.22437 ? 211 ALA   A N   1 
ATOM   1620 C CA  . ALA   A 1 211 ? -25.91300 -27.59239 13.57789  1.000 15.04412 ? 211 ALA   A CA  1 
ATOM   1621 C C   . ALA   A 1 211 ? -26.44716 -27.99510 14.95284  1.000 18.98990 ? 211 ALA   A C   1 
ATOM   1622 O O   . ALA   A 1 211 ? -27.66416 -27.96327 15.19073  1.000 17.72811 ? 211 ALA   A O   1 
ATOM   1623 C CB  . ALA   A 1 211 ? -25.47598 -28.79979 12.75784  1.000 13.69573 ? 211 ALA   A CB  1 
ATOM   1624 N N   . VAL   A 1 212 ? -25.55728 -28.30408 15.89519  1.000 15.76431 ? 212 VAL   A N   1 
ATOM   1625 C CA  . VAL   A 1 212 ? -26.01951 -28.57557 17.25824  1.000 17.19092 ? 212 VAL   A CA  1 
ATOM   1626 C C   . VAL   A 1 212 ? -26.80074 -27.38941 17.80854  1.000 18.11886 ? 212 VAL   A C   1 
ATOM   1627 O O   . VAL   A 1 212 ? -27.86355 -27.55799 18.42311  1.000 23.56574 ? 212 VAL   A O   1 
ATOM   1628 C CB  . VAL   A 1 212 ? -24.84089 -28.95499 18.17299  1.000 17.77481 ? 212 VAL   A CB  1 
ATOM   1629 C CG1 . VAL   A 1 212 ? -25.30047 -29.04604 19.62912  1.000 18.04603 ? 212 VAL   A CG1 1 
ATOM   1630 C CG2 . VAL   A 1 212 ? -24.26435 -30.29817 17.71049  1.000 12.79388 ? 212 VAL   A CG2 1 
ATOM   1631 N N   . ILE   A 1 213 ? -26.28429 -26.17174 17.60808  1.000 16.88378 ? 213 ILE   A N   1 
ATOM   1632 C CA  . ILE   A 1 213 ? -26.94715 -24.98459 18.14524  1.000 18.27514 ? 213 ILE   A CA  1 
ATOM   1633 C C   . ILE   A 1 213 ? -28.33323 -24.83686 17.56050  1.000 19.47350 ? 213 ILE   A C   1 
ATOM   1634 O O   . ILE   A 1 213 ? -29.25054 -24.34196 18.22748  1.000 25.46551 ? 213 ILE   A O   1 
ATOM   1635 C CB  . ILE   A 1 213 ? -26.09651 -23.72459 17.90068  1.000 21.73461 ? 213 ILE   A CB  1 
ATOM   1636 C CG1 . ILE   A 1 213 ? -24.85003 -23.77161 18.78242  1.000 22.77293 ? 213 ILE   A CG1 1 
ATOM   1637 C CG2 . ILE   A 1 213 ? -26.90634 -22.47185 18.18213  1.000 24.48376 ? 213 ILE   A CG2 1 
ATOM   1638 C CD1 . ILE   A 1 213 ? -23.76583 -22.75237 18.43147  1.000 19.85969 ? 213 ILE   A CD1 1 
ATOM   1639 N N   . ASN   A 1 214 ? -28.53083 -25.32278 16.34310  1.000 20.49755 ? 214 ASN   A N   1 
ATOM   1640 C CA  . ASN   A 1 214 ? -29.80333 -25.22229 15.64733  1.000 20.31830 ? 214 ASN   A CA  1 
ATOM   1641 C C   . ASN   A 1 214 ? -30.66478 -26.48680 15.75778  1.000 23.70518 ? 214 ASN   A C   1 
ATOM   1642 O O   . ASN   A 1 214 ? -31.68646 -26.59276 15.06338  1.000 25.86868 ? 214 ASN   A O   1 
ATOM   1643 C CB  . ASN   A 1 214 ? -29.54082 -24.89739 14.19048  1.000 20.10783 ? 214 ASN   A CB  1 
ATOM   1644 C CG  . ASN   A 1 214 ? -29.42763 -23.41838 13.96803  1.000 24.01929 ? 214 ASN   A CG  1 
ATOM   1645 O OD1 . ASN   A 1 214 ? -30.42910 -22.74772 13.71845  1.000 26.01117 ? 214 ASN   A OD1 1 
ATOM   1646 N ND2 . ASN   A 1 214 ? -28.20202 -22.90154 14.00018  1.000 23.65412 ? 214 ASN   A ND2 1 
ATOM   1647 N N   . GLY   A 1 215 ? -30.25920 -27.46169 16.57405  1.000 20.20411 ? 215 GLY   A N   1 
ATOM   1648 C CA  . GLY   A 1 215 ? -31.08807 -28.61163 16.89195  1.000 21.29824 ? 215 GLY   A CA  1 
ATOM   1649 C C   . GLY   A 1 215 ? -30.77810 -29.89908 16.15336  1.000 22.63659 ? 215 GLY   A C   1 
ATOM   1650 O O   . GLY   A 1 215 ? -31.45837 -30.90191 16.40554  1.000 22.10796 ? 215 GLY   A O   1 
ATOM   1651 N N   . ASP   A 1 216 ? -29.80523 -29.90787 15.22836  1.000 18.70800 ? 216 ASP   A N   1 
ATOM   1652 C CA  . ASP   A 1 216 ? -29.34708 -31.14612 14.59429  1.000 19.50919 ? 216 ASP   A CA  1 
ATOM   1653 C C   . ASP   A 1 216 ? -28.32466 -31.80028 15.51642  1.000 23.73007 ? 216 ASP   A C   1 
ATOM   1654 O O   . ASP   A 1 216 ? -27.23228 -31.25200 15.71623  1.000 20.88917 ? 216 ASP   A O   1 
ATOM   1655 C CB  . ASP   A 1 216 ? -28.70523 -30.88376 13.22462  1.000 23.91029 ? 216 ASP   A CB  1 
ATOM   1656 C CG  . ASP   A 1 216 ? -29.72241 -30.67844 12.11657  1.000 29.06680 ? 216 ASP   A CG  1 
ATOM   1657 O OD1 . ASP   A 1 216 ? -30.80055 -31.29033 12.21716  1.000 30.70914 ? 216 ASP   A OD1 1 
ATOM   1658 O OD2 . ASP   A 1 216 ? -29.43283 -29.94770 11.13194  1.000 25.69957 ? 216 ASP   A OD2 1 
ATOM   1659 N N   . ARG   A 1 217 ? -28.66105 -32.97865 16.08161  1.000 21.19661 ? 217 ARG   A N   1 
ATOM   1660 C CA  . ARG   A 1 217 ? -27.78510 -33.64691 17.04051  1.000 17.98349 ? 217 ARG   A CA  1 
ATOM   1661 C C   . ARG   A 1 217 ? -27.55620 -35.11485 16.73403  1.000 20.12531 ? 217 ARG   A C   1 
ATOM   1662 O O   . ARG   A 1 217 ? -26.85660 -35.77796 17.50441  1.000 19.14918 ? 217 ARG   A O   1 
ATOM   1663 C CB  . ARG   A 1 217 ? -28.35742 -33.56888 18.46521  1.000 18.08801 ? 217 ARG   A CB  1 
ATOM   1664 C CG  . ARG   A 1 217 ? -28.77643 -32.20648 18.95027  1.000 21.71570 ? 217 ARG   A CG  1 
ATOM   1665 C CD  . ARG   A 1 217 ? -29.32596 -32.27287 20.40946  1.000 23.06713 ? 217 ARG   A CD  1 
ATOM   1666 N NE  . ARG   A 1 217 ? -28.38762 -32.90503 21.33208  1.000 21.89252 ? 217 ARG   A NE  1 
ATOM   1667 C CZ  . ARG   A 1 217 ? -27.45119 -32.27232 22.03199  1.000 20.38452 ? 217 ARG   A CZ  1 
ATOM   1668 N NH1 . ARG   A 1 217 ? -27.29938 -30.95800 21.98456  1.000 20.75801 ? 217 ARG   A NH1 1 
ATOM   1669 N NH2 . ARG   A 1 217 ? -26.65503 -32.97396 22.79287  1.000 18.44451 ? 217 ARG   A NH2 1 
ATOM   1670 N N   . TRP   A 1 218 ? -28.14786 -35.64658 15.66141  1.000 16.75478 ? 218 TRP   A N   1 
ATOM   1671 C CA  . TRP   A 1 218 ? -28.11999 -37.07904 15.39376  1.000 19.21909 ? 218 TRP   A CA  1 
ATOM   1672 C C   . TRP   A 1 218 ? -26.71049 -37.63731 15.21543  1.000 21.42249 ? 218 TRP   A C   1 
ATOM   1673 O O   . TRP   A 1 218 ? -26.50324 -38.84126 15.40455  1.000 16.91481 ? 218 TRP   A O   1 
ATOM   1674 C CB  . TRP   A 1 218 ? -28.95780 -37.39281 14.14920  1.000 24.45726 ? 218 TRP   A CB  1 
ATOM   1675 C CG  . TRP   A 1 218 ? -28.47774 -36.78054 12.82922  1.000 21.68067 ? 218 TRP   A CG  1 
ATOM   1676 C CD1 . TRP   A 1 218 ? -28.97367 -35.66052 12.21798  1.000 21.83119 ? 218 TRP   A CD1 1 
ATOM   1677 C CD2 . TRP   A 1 218 ? -27.45942 -37.28734 11.95901  1.000 21.43521 ? 218 TRP   A CD2 1 
ATOM   1678 N NE1 . TRP   A 1 218 ? -28.31588 -35.43591 11.03331  1.000 23.18175 ? 218 TRP   A NE1 1 
ATOM   1679 C CE2 . TRP   A 1 218 ? -27.39023 -36.42358 10.84497  1.000 23.01120 ? 218 TRP   A CE2 1 
ATOM   1680 C CE3 . TRP   A 1 218 ? -26.60067 -38.38780 12.00882  1.000 24.50904 ? 218 TRP   A CE3 1 
ATOM   1681 C CZ2 . TRP   A 1 218 ? -26.48732 -36.61753 9.80123   1.000 23.05760 ? 218 TRP   A CZ2 1 
ATOM   1682 C CZ3 . TRP   A 1 218 ? -25.70305 -38.57953 10.97035  1.000 26.12004 ? 218 TRP   A CZ3 1 
ATOM   1683 C CH2 . TRP   A 1 218 ? -25.65019 -37.69051 9.88354   1.000 24.84186 ? 218 TRP   A CH2 1 
ATOM   1684 N N   . PHE   A 1 219 ? -25.75279 -36.80228 14.82388  1.000 20.09238 ? 219 PHE   A N   1 
ATOM   1685 C CA  . PHE   A 1 219 ? -24.38114 -37.21239 14.56613  1.000 22.25098 ? 219 PHE   A CA  1 
ATOM   1686 C C   . PHE   A 1 219 ? -23.52450 -37.18034 15.82148  1.000 17.05375 ? 219 PHE   A C   1 
ATOM   1687 O O   . PHE   A 1 219 ? -22.32902 -37.49802 15.75591  1.000 19.27177 ? 219 PHE   A O   1 
ATOM   1688 C CB  . PHE   A 1 219 ? -23.76909 -36.29773 13.49481  1.000 21.60104 ? 219 PHE   A CB  1 
ATOM   1689 C CG  . PHE   A 1 219 ? -23.94241 -34.83855 13.80462  1.000 15.43145 ? 219 PHE   A CG  1 
ATOM   1690 C CD1 . PHE   A 1 219 ? -23.04555 -34.19117 14.63437  1.000 15.43272 ? 219 PHE   A CD1 1 
ATOM   1691 C CD2 . PHE   A 1 219 ? -25.02502 -34.12256 13.28587  1.000 18.20491 ? 219 PHE   A CD2 1 
ATOM   1692 C CE1 . PHE   A 1 219 ? -23.19043 -32.84533 14.94848  1.000 17.58546 ? 219 PHE   A CE1 1 
ATOM   1693 C CE2 . PHE   A 1 219 ? -25.18872 -32.76695 13.58128  1.000 17.81307 ? 219 PHE   A CE2 1 
ATOM   1694 C CZ  . PHE   A 1 219 ? -24.26978 -32.12396 14.42317  1.000 16.98085 ? 219 PHE   A CZ  1 
ATOM   1695 N N   . LEU   A 1 220 ? -24.10248 -36.78809 16.94891  1.000 17.83402 ? 220 LEU   A N   1 
ATOM   1696 C CA  . LEU   A 1 220 ? -23.35734 -36.76032 18.18983  1.000 22.26607 ? 220 LEU   A CA  1 
ATOM   1697 C C   . LEU   A 1 220 ? -23.20092 -38.18057 18.72879  1.000 25.17110 ? 220 LEU   A C   1 
ATOM   1698 O O   . LEU   A 1 220 ? -23.99324 -39.08749 18.43925  1.000 22.69679 ? 220 LEU   A O   1 
ATOM   1699 C CB  . LEU   A 1 220 ? -24.04989 -35.86290 19.22210  1.000 18.20710 ? 220 LEU   A CB  1 
ATOM   1700 C CG  . LEU   A 1 220 ? -24.08243 -34.37275 18.87175  1.000 17.07353 ? 220 LEU   A CG  1 
ATOM   1701 C CD1 . LEU   A 1 220 ? -24.81760 -33.60936 19.88903  1.000 16.14509 ? 220 LEU   A CD1 1 
ATOM   1702 C CD2 . LEU   A 1 220 ? -22.63015 -33.83211 18.73417  1.000 17.33099 ? 220 LEU   A CD2 1 
ATOM   1703 N N   . ASN   A 1 221 ? -22.16332 -38.36666 19.52684  1.000 25.37344 ? 221 ASN   A N   1 
ATOM   1704 C CA  . ASN   A 1 221 ? -21.96519 -39.66146 20.14255  1.000 29.39714 ? 221 ASN   A CA  1 
ATOM   1705 C C   . ASN   A 1 221 ? -21.21192 -39.46653 21.44306  1.000 34.36220 ? 221 ASN   A C   1 
ATOM   1706 O O   . ASN   A 1 221 ? -20.63673 -38.40452 21.69035  1.000 28.45903 ? 221 ASN   A O   1 
ATOM   1707 C CB  . ASN   A 1 221 ? -21.24786 -40.59686 19.17772  1.000 32.80783 ? 221 ASN   A CB  1 
ATOM   1708 C CG  . ASN   A 1 221 ? -19.96879 -39.99582 18.64636  1.000 36.78073 ? 221 ASN   A CG  1 
ATOM   1709 O OD1 . ASN   A 1 221 ? -19.01377 -39.73414 19.39103  1.000 38.60062 ? 221 ASN   A OD1 1 
ATOM   1710 N ND2 . ASN   A 1 221 ? -19.96776 -39.70216 17.35275  1.000 33.14024 ? 221 ASN   A ND2 1 
ATOM   1711 N N   . ARG   A 1 222 ? -21.27338 -40.49639 22.29621  1.000 34.14246 ? 222 ARG   A N   1 
ATOM   1712 C CA  . ARG   A 1 222 ? -20.52074 -40.54551 23.54610  1.000 39.36475 ? 222 ARG   A CA  1 
ATOM   1713 C C   . ARG   A 1 222 ? -19.02458 -40.78332 23.34590  1.000 36.05211 ? 222 ARG   A C   1 
ATOM   1714 O O   . ARG   A 1 222 ? -18.27163 -40.59687 24.30327  1.000 47.21448 ? 222 ARG   A O   1 
ATOM   1715 C CB  . ARG   A 1 222 ? -21.05964 -41.65468 24.45418  1.000 40.38953 ? 222 ARG   A CB  1 
ATOM   1716 C CG  . ARG   A 1 222 ? -20.49683 -43.04633 24.07547  1.000 44.12108 ? 222 ARG   A CG  1 
ATOM   1717 C CD  . ARG   A 1 222 ? -21.21300 -44.20756 24.77249  1.000 42.63146 ? 222 ARG   A CD  1 
ATOM   1718 N NE  . ARG   A 1 222 ? -20.78993 -44.33656 26.16756  1.000 51.52261 ? 222 ARG   A NE  1 
ATOM   1719 C CZ  . ARG   A 1 222 ? -21.25114 -45.24616 27.02582  1.000 50.68449 ? 222 ARG   A CZ  1 
ATOM   1720 N NH1 . ARG   A 1 222 ? -22.16775 -46.13625 26.64942  1.000 44.44586 ? 222 ARG   A NH1 1 
ATOM   1721 N NH2 . ARG   A 1 222 ? -20.79870 -45.25320 28.27549  1.000 53.86738 ? 222 ARG   A NH2 1 
ATOM   1722 N N   . PHE   A 1 223 ? -18.57970 -41.19934 22.15545  1.000 41.35154 ? 223 PHE   A N   1 
ATOM   1723 C CA  . PHE   A 1 223 ? -17.16410 -41.45199 21.89408  1.000 39.44245 ? 223 PHE   A CA  1 
ATOM   1724 C C   . PHE   A 1 223 ? -16.34275 -40.17424 22.04327  1.000 39.32285 ? 223 PHE   A C   1 
ATOM   1725 O O   . PHE   A 1 223 ? -16.85755 -39.05410 21.96570  1.000 35.37469 ? 223 PHE   A O   1 
ATOM   1726 C CB  . PHE   A 1 223 ? -16.95502 -41.99090 20.47606  1.000 38.46356 ? 223 PHE   A CB  1 
ATOM   1727 C CG  . PHE   A 1 223 ? -17.79552 -43.18814 20.14785  1.000 47.97419 ? 223 PHE   A CG  1 
ATOM   1728 C CD1 . PHE   A 1 223 ? -17.46159 -44.44725 20.61688  1.000 57.17467 ? 223 PHE   A CD1 1 
ATOM   1729 C CD2 . PHE   A 1 223 ? -18.94093 -43.04933 19.37615  1.000 48.22995 ? 223 PHE   A CD2 1 
ATOM   1730 C CE1 . PHE   A 1 223 ? -18.25684 -45.55800 20.30729  1.000 58.84955 ? 223 PHE   A CE1 1 
ATOM   1731 C CE2 . PHE   A 1 223 ? -19.75186 -44.14702 19.07071  1.000 53.80068 ? 223 PHE   A CE2 1 
ATOM   1732 C CZ  . PHE   A 1 223 ? -19.40513 -45.40444 19.53266  1.000 56.49253 ? 223 PHE   A CZ  1 
ATOM   1733 N N   . THR   A 1 224 ? -15.04247 -40.35077 22.26387  1.000 32.11479 ? 224 THR   A N   1 
ATOM   1734 C CA  . THR   A 1 224 ? -14.09342 -39.26625 22.07707  1.000 32.36776 ? 224 THR   A CA  1 
ATOM   1735 C C   . THR   A 1 224 ? -12.88865 -39.79745 21.30834  1.000 31.76815 ? 224 THR   A C   1 
ATOM   1736 O O   . THR   A 1 224 ? -12.82986 -40.97701 20.94470  1.000 35.95658 ? 224 THR   A O   1 
ATOM   1737 C CB  . THR   A 1 224 ? -13.64864 -38.66531 23.40572  1.000 35.80615 ? 224 THR   A CB  1 
ATOM   1738 O OG1 . THR   A 1 224 ? -13.00267 -37.41512 23.13638  1.000 33.28276 ? 224 THR   A OG1 1 
ATOM   1739 C CG2 . THR   A 1 224 ? -12.65914 -39.64313 24.14828  1.000 35.10869 ? 224 THR   A CG2 1 
ATOM   1740 N N   . THR   A 1 225 ? -11.91826 -38.91845 21.05939  1.000 29.69391 ? 225 THR   A N   1 
ATOM   1741 C CA  . THR   A 1 225 ? -10.68995 -39.30826 20.37887  1.000 32.03935 ? 225 THR   A CA  1 
ATOM   1742 C C   . THR   A 1 225 ? -9.57584  -38.34989 20.78172  1.000 31.09575 ? 225 THR   A C   1 
ATOM   1743 O O   . THR   A 1 225 ? -9.81340  -37.27182 21.33679  1.000 31.64141 ? 225 THR   A O   1 
ATOM   1744 C CB  . THR   A 1 225 ? -10.87960 -39.30663 18.85149  1.000 35.25004 ? 225 THR   A CB  1 
ATOM   1745 O OG1 . THR   A 1 225 ? -9.79603  -39.99290 18.21254  1.000 35.56443 ? 225 THR   A OG1 1 
ATOM   1746 C CG2 . THR   A 1 225 ? -10.94127 -37.87243 18.33416  1.000 29.42635 ? 225 THR   A CG2 1 
ATOM   1747 N N   . THR   A 1 226 ? -8.34827  -38.74785 20.49619  1.000 31.32434 ? 226 THR   A N   1 
ATOM   1748 C CA  . THR   A 1 226 ? -7.22311  -37.85363 20.70156  1.000 29.45080 ? 226 THR   A CA  1 
ATOM   1749 C C   . THR   A 1 226 ? -7.00040  -37.03647 19.43533  1.000 26.72145 ? 226 THR   A C   1 
ATOM   1750 O O   . THR   A 1 226 ? -7.40417  -37.43387 18.33606  1.000 27.62761 ? 226 THR   A O   1 
ATOM   1751 C CB  . THR   A 1 226 ? -5.96066  -38.63727 21.07967  1.000 32.48261 ? 226 THR   A CB  1 
ATOM   1752 O OG1 . THR   A 1 226 ? -5.44121  -39.30149 19.92402  1.000 32.11629 ? 226 THR   A OG1 1 
ATOM   1753 C CG2 . THR   A 1 226 ? -6.28281  -39.70325 22.11848  1.000 34.02145 ? 226 THR   A CG2 1 
ATOM   1754 N N   . LEU   A 1 227 ? -6.40213  -35.86108 19.61188  1.000 24.02884 ? 227 LEU   A N   1 
ATOM   1755 C CA  . LEU   A 1 227 ? -6.06163  -35.02763 18.46535  1.000 27.34085 ? 227 LEU   A CA  1 
ATOM   1756 C C   . LEU   A 1 227 ? -5.20429  -35.78863 17.45295  1.000 34.41554 ? 227 LEU   A C   1 
ATOM   1757 O O   . LEU   A 1 227 ? -5.45135  -35.71428 16.24163  1.000 27.25913 ? 227 LEU   A O   1 
ATOM   1758 C CB  . LEU   A 1 227 ? -5.35948  -33.76104 18.94477  1.000 25.06124 ? 227 LEU   A CB  1 
ATOM   1759 C CG  . LEU   A 1 227 ? -5.11203  -32.69985 17.88146  1.000 27.85913 ? 227 LEU   A CG  1 
ATOM   1760 C CD1 . LEU   A 1 227 ? -6.39110  -32.38999 17.10723  1.000 27.64305 ? 227 LEU   A CD1 1 
ATOM   1761 C CD2 . LEU   A 1 227 ? -4.56525  -31.44180 18.53852  1.000 29.37868 ? 227 LEU   A CD2 1 
ATOM   1762 N N   . ASN   A 1 228 ? -4.20665  -36.55387 17.92729  1.000 30.00110 ? 228 ASN   A N   1 
ATOM   1763 C CA  . ASN   A 1 228 ? -3.36150  -37.30217 16.99879  1.000 33.25772 ? 228 ASN   A CA  1 
ATOM   1764 C C   . ASN   A 1 228 ? -4.15681  -38.36270 16.24594  1.000 31.40499 ? 228 ASN   A C   1 
ATOM   1765 O O   . ASN   A 1 228 ? -3.97114  -38.53875 15.03623  1.000 32.98915 ? 228 ASN   A O   1 
ATOM   1766 C CB  . ASN   A 1 228 ? -2.18578  -37.94793 17.73818  1.000 36.56588 ? 228 ASN   A CB  1 
ATOM   1767 C CG  . ASN   A 1 228 ? -1.19118  -36.92712 18.23696  1.000 39.16155 ? 228 ASN   A CG  1 
ATOM   1768 O OD1 . ASN   A 1 228 ? -0.94044  -35.91686 17.57672  1.000 44.81368 ? 228 ASN   A OD1 1 
ATOM   1769 N ND2 . ASN   A 1 228 ? -0.61282  -37.18222 19.40703  1.000 44.93057 ? 228 ASN   A ND2 1 
ATOM   1770 N N   . ASP   A 1 229 ? -5.04714  -39.08074 16.93292  1.000 31.20653 ? 229 ASP   A N   1 
ATOM   1771 C CA  . ASP   A 1 229 ? -5.81075  -40.12280 16.24872  1.000 34.20540 ? 229 ASP   A CA  1 
ATOM   1772 C C   . ASP   A 1 229 ? -6.86040  -39.51595 15.31844  1.000 31.54193 ? 229 ASP   A C   1 
ATOM   1773 O O   . ASP   A 1 229 ? -7.21542  -40.11833 14.29539  1.000 28.59019 ? 229 ASP   A O   1 
ATOM   1774 C CB  . ASP   A 1 229 ? -6.46298  -41.06060 17.27119  1.000 36.25088 ? 229 ASP   A CB  1 
ATOM   1775 C CG  . ASP   A 1 229 ? -5.43402  -41.84958 18.08800  1.000 41.97701 ? 229 ASP   A CG  1 
ATOM   1776 O OD1 . ASP   A 1 229 ? -4.28187  -42.00039 17.61273  1.000 41.84091 ? 229 ASP   A OD1 1 
ATOM   1777 O OD2 . ASP   A 1 229 ? -5.78143  -42.28894 19.21384  1.000 45.96315 ? 229 ASP   A OD2 1 
ATOM   1778 N N   . PHE   A 1 230 ? -7.35210  -38.31901 15.63755  1.000 27.47310 ? 230 PHE   A N   1 
ATOM   1779 C CA  . PHE   A 1 230 ? -8.21498  -37.63922 14.68346  1.000 27.69069 ? 230 PHE   A CA  1 
ATOM   1780 C C   . PHE   A 1 230 ? -7.43733  -37.27498 13.42312  1.000 26.16809 ? 230 PHE   A C   1 
ATOM   1781 O O   . PHE   A 1 230 ? -7.85192  -37.60998 12.30662  1.000 25.36355 ? 230 PHE   A O   1 
ATOM   1782 C CB  . PHE   A 1 230 ? -8.85112  -36.39743 15.30285  1.000 28.99278 ? 230 PHE   A CB  1 
ATOM   1783 C CG  . PHE   A 1 230 ? -9.63353  -35.61137 14.30286  1.000 27.02821 ? 230 PHE   A CG  1 
ATOM   1784 C CD1 . PHE   A 1 230 ? -10.88939 -36.04697 13.89839  1.000 25.10500 ? 230 PHE   A CD1 1 
ATOM   1785 C CD2 . PHE   A 1 230 ? -9.07761  -34.49952 13.68562  1.000 25.75220 ? 230 PHE   A CD2 1 
ATOM   1786 C CE1 . PHE   A 1 230 ? -11.59700 -35.35077 12.93107  1.000 24.68038 ? 230 PHE   A CE1 1 
ATOM   1787 C CE2 . PHE   A 1 230 ? -9.78531  -33.80801 12.70852  1.000 27.50270 ? 230 PHE   A CE2 1 
ATOM   1788 C CZ  . PHE   A 1 230 ? -11.03803 -34.23233 12.33752  1.000 21.85932 ? 230 PHE   A CZ  1 
ATOM   1789 N N   . ASN   A 1 231 ? -6.27363  -36.64096 13.59079  1.000 27.96354 ? 231 ASN   A N   1 
ATOM   1790 C CA  . ASN   A 1 231 ? -5.51089  -36.18165 12.43855  1.000 29.21620 ? 231 ASN   A CA  1 
ATOM   1791 C C   . ASN   A 1 231 ? -5.06118  -37.33324 11.56306  1.000 29.34251 ? 231 ASN   A C   1 
ATOM   1792 O O   . ASN   A 1 231 ? -4.84243  -37.12061 10.36505  1.000 28.83708 ? 231 ASN   A O   1 
ATOM   1793 C CB  . ASN   A 1 231 ? -4.30838  -35.34103 12.87780  1.000 28.33118 ? 231 ASN   A CB  1 
ATOM   1794 C CG  . ASN   A 1 231 ? -4.69220  -33.89597 13.09452  1.000 28.56397 ? 231 ASN   A CG  1 
ATOM   1795 O OD1 . ASN   A 1 231 ? -5.46765  -33.34987 12.31951  1.000 32.10540 ? 231 ASN   A OD1 1 
ATOM   1796 N ND2 . ASN   A 1 231 ? -4.16453  -33.27064 14.14558  1.000 26.09988 ? 231 ASN   A ND2 1 
ATOM   1797 N N   . LEU   A 1 232 ? -4.94359  -38.54955 12.11394  1.000 29.65879 ? 232 LEU   A N   1 
ATOM   1798 C CA  . LEU   A 1 232 ? -4.71916  -39.67432 11.22186  1.000 31.43851 ? 232 LEU   A CA  1 
ATOM   1799 C C   . LEU   A 1 232 ? -5.89770  -39.86558 10.29740  1.000 32.44735 ? 232 LEU   A C   1 
ATOM   1800 O O   . LEU   A 1 232 ? -5.71596  -40.16320 9.11620   1.000 32.45334 ? 232 LEU   A O   1 
ATOM   1801 C CB  . LEU   A 1 232 ? -4.44755  -40.99503 11.93661  1.000 33.07301 ? 232 LEU   A CB  1 
ATOM   1802 C CG  . LEU   A 1 232 ? -3.09471  -41.11271 12.61599  1.000 35.78779 ? 232 LEU   A CG  1 
ATOM   1803 C CD1 . LEU   A 1 232 ? -2.91681  -42.53824 13.23640  1.000 38.71745 ? 232 LEU   A CD1 1 
ATOM   1804 C CD2 . LEU   A 1 232 ? -1.96994  -40.64813 11.65677  1.000 32.16656 ? 232 LEU   A CD2 1 
ATOM   1805 N N   . VAL   A 1 233 ? -7.11709  -39.70907 10.80720  1.000 28.60275 ? 233 VAL   A N   1 
ATOM   1806 C CA  . VAL   A 1 233 ? -8.26952  -39.91460 9.93897   1.000 30.28324 ? 233 VAL   A CA  1 
ATOM   1807 C C   . VAL   A 1 233 ? -8.39349  -38.76137 8.94611   1.000 30.83248 ? 233 VAL   A C   1 
ATOM   1808 O O   . VAL   A 1 233 ? -8.68254  -38.96873 7.75990   1.000 31.44727 ? 233 VAL   A O   1 
ATOM   1809 C CB  . VAL   A 1 233 ? -9.54578  -40.09617 10.77967  1.000 33.94648 ? 233 VAL   A CB  1 
ATOM   1810 C CG1 . VAL   A 1 233 ? -10.80582 -40.03025 9.89283   1.000 30.62273 ? 233 VAL   A CG1 1 
ATOM   1811 C CG2 . VAL   A 1 233 ? -9.47522  -41.39359 11.58052  1.000 33.79952 ? 233 VAL   A CG2 1 
ATOM   1812 N N   . ALA   A 1 234 ? -8.15240  -37.53294 9.41085   1.000 29.72954 ? 234 ALA   A N   1 
ATOM   1813 C CA  . ALA   A 1 234 ? -8.22343  -36.36240 8.54309   1.000 28.96681 ? 234 ALA   A CA  1 
ATOM   1814 C C   . ALA   A 1 234 ? -7.34406  -36.53471 7.31100   1.000 29.40405 ? 234 ALA   A C   1 
ATOM   1815 O O   . ALA   A 1 234 ? -7.78557  -36.31294 6.17853   1.000 26.37457 ? 234 ALA   A O   1 
ATOM   1816 C CB  . ALA   A 1 234 ? -7.80815  -35.11193 9.32349   1.000 27.81543 ? 234 ALA   A CB  1 
ATOM   1817 N N   . MET   A 1 235 ? -6.09408  -36.95282 7.51628   1.000 30.73979 ? 235 MET   A N   1 
ATOM   1818 C CA  . MET   A 1 235 ? -5.17957  -37.11847 6.39409   1.000 29.91415 ? 235 MET   A CA  1 
ATOM   1819 C C   . MET   A 1 235 ? -5.73995  -38.08833 5.35268   1.000 31.18858 ? 235 MET   A C   1 
ATOM   1820 O O   . MET   A 1 235 ? -5.67834  -37.81476 4.14687   1.000 28.63223 ? 235 MET   A O   1 
ATOM   1821 C CB  . MET   A 1 235 ? -3.82614  -37.59253 6.91786   1.000 32.28278 ? 235 MET   A CB  1 
ATOM   1822 C CG  . MET   A 1 235 ? -2.82026  -38.01371 5.85509   1.000 40.31930 ? 235 MET   A CG  1 
ATOM   1823 S SD  . MET   A 1 235 ? -1.16374  -37.47272 6.36330   1.000 53.92446 ? 235 MET   A SD  1 
ATOM   1824 C CE  . MET   A 1 235 ? -1.00592  -38.35709 7.91859   1.000 38.86989 ? 235 MET   A CE  1 
ATOM   1825 N N   . LYS   A 1 236 ? -6.32732  -39.20960 5.79426   1.000 31.99899 ? 236 LYS   A N   1 
ATOM   1826 C CA  . LYS   A 1 236 ? -6.80094  -40.20474 4.83154   1.000 27.83136 ? 236 LYS   A CA  1 
ATOM   1827 C C   . LYS   A 1 236 ? -7.97883  -39.70340 4.01984   1.000 27.83324 ? 236 LYS   A C   1 
ATOM   1828 O O   . LYS   A 1 236 ? -8.15548  -40.13288 2.87719   1.000 27.57656 ? 236 LYS   A O   1 
ATOM   1829 C CB  . LYS   A 1 236 ? -7.16308  -41.52518 5.52196   1.000 33.58748 ? 236 LYS   A CB  1 
ATOM   1830 C CG  . LYS   A 1 236 ? -5.92581  -42.41188 5.72799   1.000 40.55951 ? 236 LYS   A CG  1 
ATOM   1831 C CD  . LYS   A 1 236 ? -5.05803  -41.77018 6.80938   1.000 41.30279 ? 236 LYS   A CD  1 
ATOM   1832 C CE  . LYS   A 1 236 ? -3.79049  -42.49342 7.20408   1.000 41.52915 ? 236 LYS   A CE  1 
ATOM   1833 N NZ  . LYS   A 1 236 ? -3.11602  -41.62663 8.21191   1.000 33.66644 ? 236 LYS   A NZ  1 
ATOM   1834 N N   . TYR   A 1 237 ? -8.79354  -38.80372 4.56788   1.000 26.11564 ? 237 TYR   A N   1 
ATOM   1835 C CA  . TYR   A 1 237 ? -9.92819  -38.27305 3.82360   1.000 24.58269 ? 237 TYR   A CA  1 
ATOM   1836 C C   . TYR   A 1 237 ? -9.64351  -36.90631 3.21220   1.000 25.72894 ? 237 TYR   A C   1 
ATOM   1837 O O   . TYR   A 1 237 ? -10.57667 -36.21355 2.78981   1.000 24.63662 ? 237 TYR   A O   1 
ATOM   1838 C CB  . TYR   A 1 237 ? -11.16634 -38.22326 4.71453   1.000 24.67863 ? 237 TYR   A CB  1 
ATOM   1839 C CG  . TYR   A 1 237 ? -11.72025 -39.61001 4.99631   1.000 26.49985 ? 237 TYR   A CG  1 
ATOM   1840 C CD1 . TYR   A 1 237 ? -11.21337 -40.38253 6.02835   1.000 28.31711 ? 237 TYR   A CD1 1 
ATOM   1841 C CD2 . TYR   A 1 237 ? -12.72454 -40.15798 4.19565   1.000 27.47082 ? 237 TYR   A CD2 1 
ATOM   1842 C CE1 . TYR   A 1 237 ? -11.71707 -41.64910 6.28683   1.000 31.17088 ? 237 TYR   A CE1 1 
ATOM   1843 C CE2 . TYR   A 1 237 ? -13.23104 -41.43021 4.44537   1.000 26.51804 ? 237 TYR   A CE2 1 
ATOM   1844 C CZ  . TYR   A 1 237 ? -12.71414 -42.16606 5.48873   1.000 26.11512 ? 237 TYR   A CZ  1 
ATOM   1845 O OH  . TYR   A 1 237 ? -13.18385 -43.42339 5.76755   1.000 34.53595 ? 237 TYR   A OH  1 
ATOM   1846 N N   . ASN   A 1 238 ? -8.37355  -36.51448 3.15214   1.000 24.07775 ? 238 ASN   A N   1 
ATOM   1847 C CA  . ASN   A 1 238 ? -7.95122  -35.29449 2.47278   1.000 26.59345 ? 238 ASN   A CA  1 
ATOM   1848 C C   . ASN   A 1 238 ? -8.62727  -34.06173 3.09044   1.000 23.64894 ? 238 ASN   A C   1 
ATOM   1849 O O   . ASN   A 1 238 ? -9.15198  -33.18498 2.40255   1.000 24.64651 ? 238 ASN   A O   1 
ATOM   1850 C CB  . ASN   A 1 238 ? -8.19197  -35.42790 0.97149   1.000 25.64325 ? 238 ASN   A CB  1 
ATOM   1851 C CG  . ASN   A 1 238 ? -7.75009  -34.23077 0.21722   1.000 31.21469 ? 238 ASN   A CG  1 
ATOM   1852 O OD1 . ASN   A 1 238 ? -6.67779  -33.69226 0.50778   1.000 30.63938 ? 238 ASN   A OD1 1 
ATOM   1853 N ND2 . ASN   A 1 238 ? -8.46572  -33.89315 -0.85441  1.000 29.68047 ? 238 ASN   A ND2 1 
ATOM   1854 N N   . TYR   A 1 239 ? -8.64828  -34.05543 4.41894   1.000 22.39166 ? 239 TYR   A N   1 
ATOM   1855 C CA  . TYR   A 1 239 ? -8.96450  -32.93955 5.29003   1.000 20.61271 ? 239 TYR   A CA  1 
ATOM   1856 C C   . TYR   A 1 239 ? -7.64894  -32.37702 5.79027   1.000 22.83700 ? 239 TYR   A C   1 
ATOM   1857 O O   . TYR   A 1 239 ? -6.66189  -33.10324 5.90791   1.000 22.00960 ? 239 TYR   A O   1 
ATOM   1858 C CB  . TYR   A 1 239 ? -9.79411  -33.40558 6.48787   1.000 19.56238 ? 239 TYR   A CB  1 
ATOM   1859 C CG  . TYR   A 1 239 ? -11.28448 -33.41987 6.26032   1.000 17.12550 ? 239 TYR   A CG  1 
ATOM   1860 C CD1 . TYR   A 1 239 ? -11.83441 -34.04043 5.14255   1.000 19.51795 ? 239 TYR   A CD1 1 
ATOM   1861 C CD2 . TYR   A 1 239 ? -12.14263 -32.84120 7.18521   1.000 17.67359 ? 239 TYR   A CD2 1 
ATOM   1862 C CE1 . TYR   A 1 239 ? -13.21622 -34.06403 4.93604   1.000 17.58783 ? 239 TYR   A CE1 1 
ATOM   1863 C CE2 . TYR   A 1 239 ? -13.53119 -32.89124 7.01103   1.000 18.11708 ? 239 TYR   A CE2 1 
ATOM   1864 C CZ  . TYR   A 1 239 ? -14.05033 -33.49023 5.88108   1.000 18.02522 ? 239 TYR   A CZ  1 
ATOM   1865 O OH  . TYR   A 1 239 ? -15.40098 -33.49804 5.69708   1.000 16.61785 ? 239 TYR   A OH  1 
ATOM   1866 N N   . GLU   A 1 240 ? -7.63667  -31.12019 6.11219   1.000 19.96083 ? 240 GLU   A N   1 
ATOM   1867 C CA  . GLU   A 1 240 ? -6.31716  -30.69598 6.53565   1.000 27.17059 ? 240 GLU   A CA  1 
ATOM   1868 C C   . GLU   A 1 240 ? -6.12635  -30.91375 8.01992   1.000 22.51487 ? 240 GLU   A C   1 
ATOM   1869 O O   . GLU   A 1 240 ? -7.08166  -31.20397 8.73509   1.000 18.91520 ? 240 GLU   A O   1 
ATOM   1870 C CB  . GLU   A 1 240 ? -6.08508  -29.25999 6.13034   1.000 27.29336 ? 240 GLU   A CB  1 
ATOM   1871 C CG  . GLU   A 1 240 ? -6.93539  -28.24368 6.63294   1.000 25.52018 ? 240 GLU   A CG  1 
ATOM   1872 C CD  . GLU   A 1 240 ? -6.76979  -26.95133 5.81826   1.000 31.02343 ? 240 GLU   A CD  1 
ATOM   1873 O OE1 . GLU   A 1 240 ? -7.60138  -26.03719 6.02674   1.000 28.62854 ? 240 GLU   A OE1 1 
ATOM   1874 O OE2 . GLU   A 1 240 ? -5.83080  -26.84964 4.97633   1.000 30.76982 ? 240 GLU   A OE2 1 
ATOM   1875 N N   . PRO   A 1 241 ? -4.88626  -30.90536 8.50410   1.000 25.43770 ? 241 PRO   A N   1 
ATOM   1876 C CA  . PRO   A 1 241 ? -4.67705  -31.23178 9.91705   1.000 25.91088 ? 241 PRO   A CA  1 
ATOM   1877 C C   . PRO   A 1 241 ? -5.33059  -30.22500 10.84840  1.000 23.34953 ? 241 PRO   A C   1 
ATOM   1878 O O   . PRO   A 1 241 ? -5.43393  -29.03064 10.55552  1.000 25.56964 ? 241 PRO   A O   1 
ATOM   1879 C CB  . PRO   A 1 241 ? -3.14881  -31.22492 10.07191  1.000 25.70746 ? 241 PRO   A CB  1 
ATOM   1880 C CG  . PRO   A 1 241 ? -2.63083  -31.50222 8.70552   1.000 30.41060 ? 241 PRO   A CG  1 
ATOM   1881 C CD  . PRO   A 1 241 ? -3.60500  -30.82709 7.76396   1.000 29.21442 ? 241 PRO   A CD  1 
ATOM   1882 N N   . LEU   A 1 242 ? -5.76781  -30.72646 11.99801  1.000 21.44117 ? 242 LEU   A N   1 
ATOM   1883 C CA  . LEU   A 1 242 ? -6.29387  -29.87645 13.04986  1.000 22.66677 ? 242 LEU   A CA  1 
ATOM   1884 C C   . LEU   A 1 242 ? -5.17685  -29.59570 14.03737  1.000 22.82269 ? 242 LEU   A C   1 
ATOM   1885 O O   . LEU   A 1 242 ? -4.49203  -30.51728 14.48417  1.000 21.34253 ? 242 LEU   A O   1 
ATOM   1886 C CB  . LEU   A 1 242 ? -7.47576  -30.53357 13.76484  1.000 19.58486 ? 242 LEU   A CB  1 
ATOM   1887 C CG  . LEU   A 1 242 ? -8.39652  -29.56251 14.49053  1.000 20.49782 ? 242 LEU   A CG  1 
ATOM   1888 C CD1 . LEU   A 1 242 ? -9.14838  -28.76304 13.44469  1.000 20.16148 ? 242 LEU   A CD1 1 
ATOM   1889 C CD2 . LEU   A 1 242 ? -9.34165  -30.36096 15.37071  1.000 21.30120 ? 242 LEU   A CD2 1 
ATOM   1890 N N   . THR   A 1 243 ? -5.00773  -28.32729 14.37740  1.000 22.23010 ? 243 THR   A N   1 
ATOM   1891 C CA  . THR   A 1 243 ? -3.97820  -27.90047 15.30518  1.000 24.90300 ? 243 THR   A CA  1 
ATOM   1892 C C   . THR   A 1 243 ? -4.59057  -27.56469 16.65567  1.000 25.60154 ? 243 THR   A C   1 
ATOM   1893 O O   . THR   A 1 243 ? -5.81516  -27.43181 16.80748  1.000 22.95525 ? 243 THR   A O   1 
ATOM   1894 C CB  . THR   A 1 243 ? -3.22451  -26.69175 14.74357  1.000 22.20326 ? 243 THR   A CB  1 
ATOM   1895 O OG1 . THR   A 1 243 ? -4.07387  -25.54160 14.73849  1.000 19.88265 ? 243 THR   A OG1 1 
ATOM   1896 C CG2 . THR   A 1 243 ? -2.78837  -26.97843 13.33260  1.000 24.56076 ? 243 THR   A CG2 1 
ATOM   1897 N N   . GLN   A 1 244 ? -3.71666  -27.40540 17.65601  1.000 24.63690 ? 244 GLN   A N   1 
ATOM   1898 C CA  . GLN   A 1 244 ? -4.20454  -26.95450 18.95410  1.000 20.82401 ? 244 GLN   A CA  1 
ATOM   1899 C C   . GLN   A 1 244 ? -4.79518  -25.55734 18.85982  1.000 26.23161 ? 244 GLN   A C   1 
ATOM   1900 O O   . GLN   A 1 244 ? -5.77682  -25.25014 19.55204  1.000 21.58083 ? 244 GLN   A O   1 
ATOM   1901 C CB  . GLN   A 1 244 ? -3.09140  -26.99228 20.00186  1.000 25.63200 ? 244 GLN   A CB  1 
ATOM   1902 C CG  . GLN   A 1 244 ? -3.56759  -26.66748 21.42255  1.000 25.99107 ? 244 GLN   A CG  1 
ATOM   1903 C CD  . GLN   A 1 244 ? -4.65988  -27.59038 21.90901  1.000 24.87072 ? 244 GLN   A CD  1 
ATOM   1904 O OE1 . GLN   A 1 244 ? -4.62565  -28.79982 21.67780  1.000 24.27349 ? 244 GLN   A OE1 1 
ATOM   1905 N NE2 . GLN   A 1 244 ? -5.62819  -27.02500 22.61085  1.000 28.38186 ? 244 GLN   A NE2 1 
ATOM   1906 N N   . ASP   A 1 245 ? -4.24835  -24.69605 17.99322  1.000 22.77350 ? 245 ASP   A N   1 
ATOM   1907 C CA  . ASP   A 1 245 ? -4.87338  -23.38552 17.87054  1.000 24.73357 ? 245 ASP   A CA  1 
ATOM   1908 C C   . ASP   A 1 245 ? -6.30562  -23.48573 17.33601  1.000 22.72701 ? 245 ASP   A C   1 
ATOM   1909 O O   . ASP   A 1 245 ? -7.16865  -22.69684 17.73472  1.000 21.73975 ? 245 ASP   A O   1 
ATOM   1910 C CB  . ASP   A 1 245 ? -4.05645  -22.44549 16.99810  1.000 22.43677 ? 245 ASP   A CB  1 
ATOM   1911 C CG  . ASP   A 1 245 ? -4.55679  -21.03248 17.12224  1.000 29.30491 ? 245 ASP   A CG  1 
ATOM   1912 O OD1 . ASP   A 1 245 ? -4.69348  -20.59439 18.28709  1.000 30.13690 ? 245 ASP   A OD1 1 
ATOM   1913 O OD2 . ASP   A 1 245 ? -4.84769  -20.38598 16.09048  1.000 37.72156 ? 245 ASP   A OD2 1 
ATOM   1914 N N   . HIS   A 1 246 ? -6.57228  -24.43262 16.42253  1.000 23.53655 ? 246 HIS   A N   1 
ATOM   1915 C CA  . HIS   A 1 246 ? -7.95109  -24.68761 15.98906  1.000 23.09559 ? 246 HIS   A CA  1 
ATOM   1916 C C   . HIS   A 1 246 ? -8.82622  -25.13547 17.15124  1.000 23.27656 ? 246 HIS   A C   1 
ATOM   1917 O O   . HIS   A 1 246 ? -9.98213  -24.70774 17.27511  1.000 21.19554 ? 246 HIS   A O   1 
ATOM   1918 C CB  . HIS   A 1 246 ? -7.98514  -25.75556 14.89363  1.000 18.17666 ? 246 HIS   A CB  1 
ATOM   1919 C CG  . HIS   A 1 246 ? -7.32121  -25.34238 13.61917  1.000 16.37719 ? 246 HIS   A CG  1 
ATOM   1920 N ND1 . HIS   A 1 246 ? -6.69693  -26.23790 12.77411  1.000 18.78568 ? 246 HIS   A ND1 1 
ATOM   1921 C CD2 . HIS   A 1 246 ? -7.15812  -24.12113 13.06272  1.000 18.15472 ? 246 HIS   A CD2 1 
ATOM   1922 C CE1 . HIS   A 1 246 ? -6.21808  -25.58776 11.72520  1.000 20.70232 ? 246 HIS   A CE1 1 
ATOM   1923 N NE2 . HIS   A 1 246 ? -6.46602  -24.29869 11.88545  1.000 21.48562 ? 246 HIS   A NE2 1 
ATOM   1924 N N   . VAL   A 1 247 ? -8.30853  -26.03616 17.99054  1.000 23.46224 ? 247 VAL   A N   1 
ATOM   1925 C CA  . VAL   A 1 247 ? -9.06407  -26.46433 19.16428  1.000 22.18988 ? 247 VAL   A CA  1 
ATOM   1926 C C   . VAL   A 1 247 ? -9.38048  -25.26417 20.04724  1.000 24.62682 ? 247 VAL   A C   1 
ATOM   1927 O O   . VAL   A 1 247 ? -10.52179 -25.08863 20.49641  1.000 25.62797 ? 247 VAL   A O   1 
ATOM   1928 C CB  . VAL   A 1 247 ? -8.29368  -27.55792 19.92555  1.000 24.97001 ? 247 VAL   A CB  1 
ATOM   1929 C CG1 . VAL   A 1 247 ? -8.95454  -27.83944 21.28660  1.000 22.21743 ? 247 VAL   A CG1 1 
ATOM   1930 C CG2 . VAL   A 1 247 ? -8.18395  -28.81555 19.05497  1.000 24.56278 ? 247 VAL   A CG2 1 
ATOM   1931 N N   . ASP   A 1 248 ? -8.39526  -24.39330 20.26729  1.000 21.72865 ? 248 ASP   A N   1 
ATOM   1932 C CA  . ASP   A 1 248 ? -8.63529  -23.20114 21.07229  1.000 25.84090 ? 248 ASP   A CA  1 
ATOM   1933 C C   . ASP   A 1 248 ? -9.68517  -22.29852 20.42661  1.000 24.24858 ? 248 ASP   A C   1 
ATOM   1934 O O   . ASP   A 1 248 ? -10.58489 -21.79117 21.10576  1.000 23.66434 ? 248 ASP   A O   1 
ATOM   1935 C CB  . ASP   A 1 248 ? -7.32610  -22.43011 21.28434  1.000 26.58726 ? 248 ASP   A CB  1 
ATOM   1936 C CG  . ASP   A 1 248 ? -6.29325  -23.21502 22.07282  1.000 26.83487 ? 248 ASP   A CG  1 
ATOM   1937 O OD1 . ASP   A 1 248 ? -6.67954  -24.18372 22.75421  1.000 28.22551 ? 248 ASP   A OD1 1 
ATOM   1938 O OD2 . ASP   A 1 248 ? -5.08350  -22.87838 21.98345  1.000 30.00063 ? 248 ASP   A OD2 1 
ATOM   1939 N N   . ILE   A 1 249 ? -9.57519  -22.06049 19.11649  1.000 20.54688 ? 249 ILE   A N   1 
ATOM   1940 C CA  . ILE   A 1 249 ? -10.54082 -21.18379 18.44976  1.000 21.27173 ? 249 ILE   A CA  1 
ATOM   1941 C C   . ILE   A 1 249 ? -11.96415 -21.72961 18.57580  1.000 18.69662 ? 249 ILE   A C   1 
ATOM   1942 O O   . ILE   A 1 249 ? -12.92916 -20.96316 18.61933  1.000 21.31452 ? 249 ILE   A O   1 
ATOM   1943 C CB  . ILE   A 1 249 ? -10.09881 -20.96599 16.98255  1.000 18.54235 ? 249 ILE   A CB  1 
ATOM   1944 C CG1 . ILE   A 1 249 ? -8.94681  -19.95776 16.92289  1.000 24.22943 ? 249 ILE   A CG1 1 
ATOM   1945 C CG2 . ILE   A 1 249 ? -11.22071 -20.48957 16.10553  1.000 24.10204 ? 249 ILE   A CG2 1 
ATOM   1946 C CD1 . ILE   A 1 249 ? -8.02923  -20.11805 15.66238  1.000 24.23298 ? 249 ILE   A CD1 1 
ATOM   1947 N N   . LEU   A 1 250 ? -12.11777 -23.04236 18.68196  1.000 22.02917 ? 250 LEU   A N   1 
ATOM   1948 C CA  . LEU   A 1 250 ? -13.43591 -23.65798 18.78660  1.000 18.15035 ? 250 LEU   A CA  1 
ATOM   1949 C C   . LEU   A 1 250 ? -13.94669 -23.68655 20.22643  1.000 21.54628 ? 250 LEU   A C   1 
ATOM   1950 O O   . LEU   A 1 250 ? -15.05199 -24.17689 20.47154  1.000 21.61560 ? 250 LEU   A O   1 
ATOM   1951 C CB  . LEU   A 1 250 ? -13.38880 -25.07142 18.18693  1.000 17.91128 ? 250 LEU   A CB  1 
ATOM   1952 C CG  . LEU   A 1 250 ? -13.18362 -25.22196 16.67568  1.000 18.09836 ? 250 LEU   A CG  1 
ATOM   1953 C CD1 . LEU   A 1 250 ? -12.96145 -26.68918 16.36911  1.000 11.73216 ? 250 LEU   A CD1 1 
ATOM   1954 C CD2 . LEU   A 1 250 ? -14.43801 -24.70681 15.97497  1.000 17.30168 ? 250 LEU   A CD2 1 
ATOM   1955 N N   . GLY   A 1 251 ? -13.18428 -23.12520 21.16562  1.000 25.71661 ? 251 GLY   A N   1 
ATOM   1956 C CA  . GLY   A 1 251 ? -13.52189 -23.11380 22.57128  1.000 24.56966 ? 251 GLY   A CA  1 
ATOM   1957 C C   . GLY   A 1 251 ? -14.87476 -22.52046 22.91958  1.000 22.24571 ? 251 GLY   A C   1 
ATOM   1958 O O   . GLY   A 1 251 ? -15.69957 -23.17225 23.56255  1.000 23.18274 ? 251 GLY   A O   1 
ATOM   1959 N N   . PRO   A 1 252 ? -15.11441 -21.25502 22.54294  1.000 22.49648 ? 252 PRO   A N   1 
ATOM   1960 C CA  . PRO   A 1 252 ? -16.45267 -20.66998 22.74766  1.000 22.52763 ? 252 PRO   A CA  1 
ATOM   1961 C C   . PRO   A 1 252 ? -17.60816 -21.53203 22.25981  1.000 26.18085 ? 252 PRO   A C   1 
ATOM   1962 O O   . PRO   A 1 252 ? -18.62031 -21.67250 22.96385  1.000 25.09742 ? 252 PRO   A O   1 
ATOM   1963 C CB  . PRO   A 1 252 ? -16.36482 -19.35350 21.96409  1.000 26.36053 ? 252 PRO   A CB  1 
ATOM   1964 C CG  . PRO   A 1 252 ? -14.91214 -18.94891 22.09591  1.000 26.68142 ? 252 PRO   A CG  1 
ATOM   1965 C CD  . PRO   A 1 252 ? -14.14024 -20.25561 22.05362  1.000 25.28249 ? 252 PRO   A CD  1 
ATOM   1966 N N   . LEU   A 1 253 ? -17.50113 -22.09127 21.05504  1.000 22.43802 ? 253 LEU   A N   1 
ATOM   1967 C CA  . LEU   A 1 253 ? -18.57256 -22.93874 20.54956  1.000 17.38901 ? 253 LEU   A CA  1 
ATOM   1968 C C   . LEU   A 1 253 ? -18.69051 -24.20151 21.39088  1.000 21.08165 ? 253 LEU   A C   1 
ATOM   1969 O O   . LEU   A 1 253 ? -19.79820 -24.62003 21.74476  1.000 20.09971 ? 253 LEU   A O   1 
ATOM   1970 C CB  . LEU   A 1 253 ? -18.31130 -23.29276 19.08894  1.000 15.72310 ? 253 LEU   A CB  1 
ATOM   1971 C CG  . LEU   A 1 253 ? -18.55132 -22.16644 18.07725  1.000 17.93820 ? 253 LEU   A CG  1 
ATOM   1972 C CD1 . LEU   A 1 253 ? -18.21443 -22.65708 16.66007  1.000 15.40013 ? 253 LEU   A CD1 1 
ATOM   1973 C CD2 . LEU   A 1 253 ? -19.98237 -21.75113 18.16332  1.000 19.83084 ? 253 LEU   A CD2 1 
ATOM   1974 N N   . SER   A 1 254 ? -17.54999 -24.81717 21.71435  1.000 15.91192 ? 254 SER   A N   1 
ATOM   1975 C CA  . SER   A 1 254 ? -17.52672 -25.93527 22.64923  1.000 20.11166 ? 254 SER   A CA  1 
ATOM   1976 C C   . SER   A 1 254 ? -18.25945 -25.60546 23.94181  1.000 22.67450 ? 254 SER   A C   1 
ATOM   1977 O O   . SER   A 1 254 ? -19.09413 -26.38367 24.42130  1.000 25.24535 ? 254 SER   A O   1 
ATOM   1978 C CB  . SER   A 1 254 ? -16.07938 -26.30903 22.97566  1.000 23.19344 ? 254 SER   A CB  1 
ATOM   1979 O OG  . SER   A 1 254 ? -16.07629 -27.54478 23.65117  1.000 25.28683 ? 254 SER   A OG  1 
ATOM   1980 N N   . ALA   A 1 255 ? -17.90907 -24.47533 24.55020  1.000 23.31729 ? 255 ALA   A N   1 
ATOM   1981 C CA  . ALA   A 1 255 ? -18.50849 -24.09288 25.82394  1.000 26.57189 ? 255 ALA   A CA  1 
ATOM   1982 C C   . ALA   A 1 255 ? -20.01208 -23.90327 25.68776  1.000 30.53797 ? 255 ALA   A C   1 
ATOM   1983 O O   . ALA   A 1 255 ? -20.79123 -24.32090 26.55682  1.000 26.23709 ? 255 ALA   A O   1 
ATOM   1984 C CB  . ALA   A 1 255 ? -17.85075 -22.80576 26.31754  1.000 24.97207 ? 255 ALA   A CB  1 
ATOM   1985 N N   . GLN   A 1 256 ? -20.43497 -23.26938 24.59449  1.000 25.48986 ? 256 GLN   A N   1 
ATOM   1986 C CA  . GLN   A 1 256 ? -21.84034 -22.94044 24.42062  1.000 26.70488 ? 256 GLN   A CA  1 
ATOM   1987 C C   . GLN   A 1 256 ? -22.68855 -24.18681 24.25017  1.000 27.98075 ? 256 GLN   A C   1 
ATOM   1988 O O   . GLN   A 1 256 ? -23.83533 -24.22908 24.70597  1.000 33.68285 ? 256 GLN   A O   1 
ATOM   1989 C CB  . GLN   A 1 256 ? -22.00196 -22.01964 23.22326  1.000 26.59185 ? 256 GLN   A CB  1 
ATOM   1990 C CG  . GLN   A 1 256 ? -23.38378 -21.49964 23.04188  1.000 33.78124 ? 256 GLN   A CG  1 
ATOM   1991 C CD  . GLN   A 1 256 ? -23.54265 -20.91590 21.68040  1.000 30.72223 ? 256 GLN   A CD  1 
ATOM   1992 O OE1 . GLN   A 1 256 ? -22.54497 -20.59844 21.01706  1.000 32.83926 ? 256 GLN   A OE1 1 
ATOM   1993 N NE2 . GLN   A 1 256 ? -24.78607 -20.72922 21.25484  1.000 30.41622 ? 256 GLN   A NE2 1 
ATOM   1994 N N   . THR   A 1 257 ? -22.15224 -25.21116 23.60560  1.000 26.54364 ? 257 THR   A N   1 
ATOM   1995 C CA  . THR   A 1 257 ? -22.92068 -26.42385 23.37320  1.000 21.45624 ? 257 THR   A CA  1 
ATOM   1996 C C   . THR   A 1 257 ? -22.69221 -27.48444 24.43926  1.000 24.10116 ? 257 THR   A C   1 
ATOM   1997 O O   . THR   A 1 257 ? -23.49061 -28.42273 24.54596  1.000 24.60775 ? 257 THR   A O   1 
ATOM   1998 C CB  . THR   A 1 257 ? -22.54259 -27.02001 22.02323  1.000 24.03463 ? 257 THR   A CB  1 
ATOM   1999 O OG1 . THR   A 1 257 ? -21.12269 -27.20746 21.99739  1.000 20.96810 ? 257 THR   A OG1 1 
ATOM   2000 C CG2 . THR   A 1 257 ? -22.95741 -26.06101 20.89234  1.000 21.90202 ? 257 THR   A CG2 1 
ATOM   2001 N N   . GLY   A 1 258 ? -21.60293 -27.37701 25.19097  1.000 24.04650 ? 258 GLY   A N   1 
ATOM   2002 C CA  . GLY   A 1 258 ? -21.22313 -28.42078 26.11982  1.000 26.74430 ? 258 GLY   A CA  1 
ATOM   2003 C C   . GLY   A 1 258 ? -20.63500 -29.64190 25.47023  1.000 27.13861 ? 258 GLY   A C   1 
ATOM   2004 O O   . GLY   A 1 258 ? -20.59190 -30.70633 26.09503  1.000 24.28488 ? 258 GLY   A O   1 
ATOM   2005 N N   . ILE   A 1 259 ? -20.18485 -29.53678 24.22557  1.000 22.54245 ? 259 ILE   A N   1 
ATOM   2006 C CA  . ILE   A 1 259 ? -19.63228 -30.67149 23.50121  1.000 21.20633 ? 259 ILE   A CA  1 
ATOM   2007 C C   . ILE   A 1 259 ? -18.16386 -30.37013 23.28302  1.000 25.90028 ? 259 ILE   A C   1 
ATOM   2008 O O   . ILE   A 1 259 ? -17.81810 -29.42569 22.56152  1.000 19.76023 ? 259 ILE   A O   1 
ATOM   2009 C CB  . ILE   A 1 259 ? -20.35332 -30.90492 22.17252  1.000 25.31445 ? 259 ILE   A CB  1 
ATOM   2010 C CG1 . ILE   A 1 259 ? -21.79782 -31.34685 22.44189  1.000 22.62379 ? 259 ILE   A CG1 1 
ATOM   2011 C CG2 . ILE   A 1 259 ? -19.56409 -31.90286 21.29688  1.000 19.81904 ? 259 ILE   A CG2 1 
ATOM   2012 C CD1 . ILE   A 1 259 ? -22.62262 -31.15315 21.31127  1.000 23.76934 ? 259 ILE   A CD1 1 
ATOM   2013 N N   . ALA   A 1 260 ? -17.30619 -31.15689 23.92883  1.000 24.30739 ? 260 ALA   A N   1 
ATOM   2014 C CA  . ALA   A 1 260 ? -15.87346 -30.92003 23.88292  1.000 24.50877 ? 260 ALA   A CA  1 
ATOM   2015 C C   . ALA   A 1 260 ? -15.37747 -31.01413 22.44679  1.000 19.43013 ? 260 ALA   A C   1 
ATOM   2016 O O   . ALA   A 1 260 ? -15.85037 -31.83591 21.66540  1.000 19.68777 ? 260 ALA   A O   1 
ATOM   2017 C CB  . ALA   A 1 260 ? -15.15124 -31.94673 24.75309  1.000 23.48642 ? 260 ALA   A CB  1 
ATOM   2018 N N   . VAL   A 1 261 ? -14.39006 -30.18905 22.10795  1.000 23.17068 ? 261 VAL   A N   1 
ATOM   2019 C CA  . VAL   A 1 261 ? -13.90962 -30.16993 20.72775  1.000 19.83110 ? 261 VAL   A CA  1 
ATOM   2020 C C   . VAL   A 1 261 ? -13.51926 -31.57277 20.27165  1.000 19.03646 ? 261 VAL   A C   1 
ATOM   2021 O O   . VAL   A 1 261 ? -13.93698 -32.03966 19.20801  1.000 17.64031 ? 261 VAL   A O   1 
ATOM   2022 C CB  . VAL   A 1 261 ? -12.74792 -29.17241 20.56765  1.000 20.06409 ? 261 VAL   A CB  1 
ATOM   2023 C CG1 . VAL   A 1 261 ? -12.08856 -29.37258 19.19287  1.000 17.88603 ? 261 VAL   A CG1 1 
ATOM   2024 C CG2 . VAL   A 1 261 ? -13.25432 -27.75430 20.71953  1.000 19.63730 ? 261 VAL   A CG2 1 
ATOM   2025 N N   . LEU   A 1 262 ? -12.74116 -32.28642 21.08247  1.000 20.50976 ? 262 LEU   A N   1 
ATOM   2026 C CA  . LEU   A 1 262 ? -12.31268 -33.62795 20.68145  1.000 20.69168 ? 262 LEU   A CA  1 
ATOM   2027 C C   . LEU   A 1 262 ? -13.49095 -34.60612 20.58682  1.000 22.83000 ? 262 LEU   A C   1 
ATOM   2028 O O   . LEU   A 1 262 ? -13.44122 -35.58417 19.81734  1.000 20.73059 ? 262 LEU   A O   1 
ATOM   2029 C CB  . LEU   A 1 262 ? -11.25917 -34.11194 21.67958  1.000 24.46580 ? 262 LEU   A CB  1 
ATOM   2030 C CG  . LEU   A 1 262 ? -9.83483  -33.55023 21.50922  1.000 23.66104 ? 262 LEU   A CG  1 
ATOM   2031 C CD1 . LEU   A 1 262 ? -8.88503  -34.35995 22.39362  1.000 33.17966 ? 262 LEU   A CD1 1 
ATOM   2032 C CD2 . LEU   A 1 262 ? -9.31463  -33.55482 20.07278  1.000 22.92929 ? 262 LEU   A CD2 1 
ATOM   2033 N N   . ASP   A 1 263 ? -14.55521 -34.37367 21.35793  1.000 21.84487 ? 263 ASP   A N   1 
ATOM   2034 C CA  . ASP   A 1 263 ? -15.75937 -35.17297 21.17689  1.000 22.01825 ? 263 ASP   A CA  1 
ATOM   2035 C C   . ASP   A 1 263 ? -16.35353 -34.92634 19.78761  1.000 20.46820 ? 263 ASP   A C   1 
ATOM   2036 O O   . ASP   A 1 263 ? -16.75829 -35.86542 19.08957  1.000 20.19410 ? 263 ASP   A O   1 
ATOM   2037 C CB  . ASP   A 1 263 ? -16.77724 -34.83283 22.27121  1.000 23.61143 ? 263 ASP   A CB  1 
ATOM   2038 C CG  . ASP   A 1 263 ? -16.39474 -35.39398 23.65399  1.000 28.65551 ? 263 ASP   A CG  1 
ATOM   2039 O OD1 . ASP   A 1 263 ? -15.29924 -35.97295 23.80632  1.000 27.27729 ? 263 ASP   A OD1 1 
ATOM   2040 O OD2 . ASP   A 1 263 ? -17.21240 -35.24333 24.58988  1.000 32.83824 ? 263 ASP   A OD2 1 
ATOM   2041 N N   . MET   A 1 264 ? -16.38621 -33.66224 19.36184  1.000 19.91178 ? 264 MET   A N   1 
ATOM   2042 C CA  . MET   A 1 264 ? -16.92795 -33.33443 18.04446  1.000 18.39650 ? 264 MET   A CA  1 
ATOM   2043 C C   . MET   A 1 264 ? -16.03252 -33.88842 16.94044  1.000 19.20107 ? 264 MET   A C   1 
ATOM   2044 O O   . MET   A 1 264 ? -16.52973 -34.40666 15.93722  1.000 18.99466 ? 264 MET   A O   1 
ATOM   2045 C CB  . MET   A 1 264 ? -17.09465 -31.81877 17.91571  1.000 16.68787 ? 264 MET   A CB  1 
ATOM   2046 C CG  . MET   A 1 264 ? -17.91423 -31.34773 16.71058  1.000 15.66890 ? 264 MET   A CG  1 
ATOM   2047 S SD  . MET   A 1 264 ? -19.58444 -31.98756 16.77076  1.000 16.64791 ? 264 MET   A SD  1 
ATOM   2048 C CE  . MET   A 1 264 ? -20.29668 -30.64332 17.71388  1.000 11.90827 ? 264 MET   A CE  1 
ATOM   2049 N N   . CYS   A 1 265 ? -14.71282 -33.88109 17.14177  1.000 20.91923 ? 265 CYS   A N   1 
ATOM   2050 C CA  . CYS   A 1 265 ? -13.83931 -34.58336 16.20517  1.000 20.76709 ? 265 CYS   A CA  1 
ATOM   2051 C C   . CYS   A 1 265 ? -14.20779 -36.05495 16.06857  1.000 22.31473 ? 265 CYS   A C   1 
ATOM   2052 O O   . CYS   A 1 265 ? -14.21464 -36.59727 14.95534  1.000 18.34849 ? 265 CYS   A O   1 
ATOM   2053 C CB  . CYS   A 1 265 ? -12.38673 -34.48020 16.64735  1.000 18.76099 ? 265 CYS   A CB  1 
ATOM   2054 S SG  . CYS   A 1 265 ? -11.70136 -32.87222 16.51797  1.000 19.03640 ? 265 CYS   A SG  1 
ATOM   2055 N N   . ALA   A 1 266 ? -14.46136 -36.73498 17.19594  1.000 21.95755 ? 266 ALA   A N   1 
ATOM   2056 C CA  . ALA   A 1 266 ? -14.90480 -38.12429 17.12491  1.000 20.49307 ? 266 ALA   A CA  1 
ATOM   2057 C C   . ALA   A 1 266 ? -16.17792 -38.25368 16.30474  1.000 23.09964 ? 266 ALA   A C   1 
ATOM   2058 O O   . ALA   A 1 266 ? -16.36915 -39.25084 15.59985  1.000 22.65570 ? 266 ALA   A O   1 
ATOM   2059 C CB  . ALA   A 1 266 ? -15.12926 -38.69091 18.52803  1.000 26.46665 ? 266 ALA   A CB  1 
ATOM   2060 N N   . SER   A 1 267 ? -17.07620 -37.26323 16.40328  1.000 22.21544 ? 267 SER   A N   1 
ATOM   2061 C CA  . SER   A 1 267 ? -18.27403 -37.28064 15.57293  1.000 20.29523 ? 267 SER   A CA  1 
ATOM   2062 C C   . SER   A 1 267 ? -17.90762 -37.12384 14.11088  1.000 21.66115 ? 267 SER   A C   1 
ATOM   2063 O O   . SER   A 1 267 ? -18.48289 -37.78875 13.24009  1.000 22.53582 ? 267 SER   A O   1 
ATOM   2064 C CB  . SER   A 1 267 ? -19.22710 -36.16537 15.99899  1.000 22.32211 ? 267 SER   A CB  1 
ATOM   2065 O OG  . SER   A 1 267 ? -19.75506 -36.41741 17.29008  1.000 24.25411 ? 267 SER   A OG  1 
ATOM   2066 N N   . LEU   A 1 268 ? -16.94901 -36.23969 13.82355  1.000 21.36086 ? 268 LEU   A N   1 
ATOM   2067 C CA  . LEU   A 1 268 ? -16.51383 -36.06504 12.44881  1.000 19.55968 ? 268 LEU   A CA  1 
ATOM   2068 C C   . LEU   A 1 268 ? -15.86257 -37.33543 11.91756  1.000 20.42986 ? 268 LEU   A C   1 
ATOM   2069 O O   . LEU   A 1 268 ? -16.12078 -37.73614 10.78150  1.000 20.16098 ? 268 LEU   A O   1 
ATOM   2070 C CB  . LEU   A 1 268 ? -15.55562 -34.87575 12.34340  1.000 20.34750 ? 268 LEU   A CB  1 
ATOM   2071 C CG  . LEU   A 1 268 ? -15.09723 -34.48557 10.93416  1.000 15.79431 ? 268 LEU   A CG  1 
ATOM   2072 C CD1 . LEU   A 1 268 ? -16.28002 -34.45130 9.97335   1.000 14.85137 ? 268 LEU   A CD1 1 
ATOM   2073 C CD2 . LEU   A 1 268 ? -14.47293 -33.11093 10.98693  1.000 18.51300 ? 268 LEU   A CD2 1 
ATOM   2074 N N   . LYS   A 1 269 ? -14.99620 -37.96860 12.71258  1.000 23.59933 ? 269 LYS   A N   1 
ATOM   2075 C CA  . LYS   A 1 269 ? -14.43923 -39.25951 12.31189  1.000 21.86322 ? 269 LYS   A CA  1 
ATOM   2076 C C   . LYS   A 1 269 ? -15.52200 -40.20476 11.82396  1.000 22.64491 ? 269 LYS   A C   1 
ATOM   2077 O O   . LYS   A 1 269 ? -15.42299 -40.76610 10.72621  1.000 24.80465 ? 269 LYS   A O   1 
ATOM   2078 C CB  . LYS   A 1 269 ? -13.68098 -39.89068 13.47602  1.000 27.29790 ? 269 LYS   A CB  1 
ATOM   2079 C CG  . LYS   A 1 269 ? -13.04586 -41.21103 13.15157  1.000 27.58225 ? 269 LYS   A CG  1 
ATOM   2080 C CD  . LYS   A 1 269 ? -12.22591 -41.69377 14.33969  1.000 31.87697 ? 269 LYS   A CD  1 
ATOM   2081 C CE  . LYS   A 1 269 ? -11.21800 -40.71964 14.88773  1.000 36.66111 ? 269 LYS   A CE  1 
ATOM   2082 N NZ  . LYS   A 1 269 ? -10.51544 -41.20013 16.15003  1.000 39.58172 ? 269 LYS   A NZ  1 
ATOM   2083 N N   . GLU   A 1 270 ? -16.57228 -40.38962 12.63485  1.000 25.45879 ? 270 GLU   A N   1 
ATOM   2084 C CA  . GLU   A 1 270 ? -17.63216 -41.34080 12.29853  1.000 27.24549 ? 270 GLU   A CA  1 
ATOM   2085 C C   . GLU   A 1 270 ? -18.34664 -40.94166 11.01252  1.000 26.67089 ? 270 GLU   A C   1 
ATOM   2086 O O   . GLU   A 1 270 ? -18.63314 -41.79370 10.16145  1.000 26.69225 ? 270 GLU   A O   1 
ATOM   2087 C CB  . GLU   A 1 270 ? -18.62680 -41.45043 13.45581  1.000 27.03485 ? 270 GLU   A CB  1 
ATOM   2088 C CG  . GLU   A 1 270 ? -18.02764 -42.09202 14.67671  1.000 32.75823 ? 270 GLU   A CG  1 
ATOM   2089 C CD  . GLU   A 1 270 ? -17.38767 -43.45579 14.37871  1.000 37.57758 ? 270 GLU   A CD  1 
ATOM   2090 O OE1 . GLU   A 1 270 ? -16.25879 -43.71942 14.87240  1.000 35.85081 ? 270 GLU   A OE1 1 
ATOM   2091 O OE2 . GLU   A 1 270 ? -18.04219 -44.27266 13.68621  1.000 38.15075 ? 270 GLU   A OE2 1 
ATOM   2092 N N   . LEU   A 1 271 ? -18.61116 -39.64129 10.84139  1.000 26.15008 ? 271 LEU   A N   1 
ATOM   2093 C CA  . LEU   A 1 271 ? -19.23079 -39.14575 9.61238   1.000 24.67278 ? 271 LEU   A CA  1 
ATOM   2094 C C   . LEU   A 1 271 ? -18.35252 -39.42338 8.39792   1.000 24.14350 ? 271 LEU   A C   1 
ATOM   2095 O O   . LEU   A 1 271 ? -18.85413 -39.75295 7.31804   1.000 23.74840 ? 271 LEU   A O   1 
ATOM   2096 C CB  . LEU   A 1 271 ? -19.48195 -37.64824 9.74800   1.000 21.46392 ? 271 LEU   A CB  1 
ATOM   2097 C CG  . LEU   A 1 271 ? -20.64433 -37.32920 10.67700  1.000 22.23244 ? 271 LEU   A CG  1 
ATOM   2098 C CD1 . LEU   A 1 271 ? -20.68796 -35.83208 10.97315  1.000 20.02146 ? 271 LEU   A CD1 1 
ATOM   2099 C CD2 . LEU   A 1 271 ? -21.92734 -37.81330 10.05174  1.000 23.89745 ? 271 LEU   A CD2 1 
ATOM   2100 N N   . LEU   A 1 272 ? -17.03280 -39.28093 8.55182   1.000 23.27346 ? 272 LEU   A N   1 
ATOM   2101 C CA  . LEU   A 1 272 ? -16.14130 -39.53097 7.42410   1.000 22.78483 ? 272 LEU   A CA  1 
ATOM   2102 C C   . LEU   A 1 272 ? -16.07630 -41.01127 7.07992   1.000 26.29618 ? 272 LEU   A C   1 
ATOM   2103 O O   . LEU   A 1 272 ? -15.96451 -41.35815 5.90091   1.000 25.74619 ? 272 LEU   A O   1 
ATOM   2104 C CB  . LEU   A 1 272 ? -14.74300 -38.99840 7.71645   1.000 20.43698 ? 272 LEU   A CB  1 
ATOM   2105 C CG  . LEU   A 1 272 ? -14.62753 -37.47342 7.77983   1.000 18.22910 ? 272 LEU   A CG  1 
ATOM   2106 C CD1 . LEU   A 1 272 ? -13.24694 -37.09505 8.27010   1.000 21.01575 ? 272 LEU   A CD1 1 
ATOM   2107 C CD2 . LEU   A 1 272 ? -14.95730 -36.83264 6.44400   1.000 20.56048 ? 272 LEU   A CD2 1 
ATOM   2108 N N   . GLN   A 1 273 ? -16.16098 -41.89262 8.08661   1.000 29.12903 ? 273 GLN   A N   1 
ATOM   2109 C CA  . GLN   A 1 273 ? -16.02524 -43.33616 7.88464   1.000 30.56039 ? 273 GLN   A CA  1 
ATOM   2110 C C   . GLN   A 1 273 ? -17.33425 -43.99289 7.48683   1.000 31.82000 ? 273 GLN   A C   1 
ATOM   2111 O O   . GLN   A 1 273 ? -17.32173 -44.96378 6.72225   1.000 33.33942 ? 273 GLN   A O   1 
ATOM   2112 C CB  . GLN   A 1 273 ? -15.45731 -43.99712 9.14684   1.000 28.85364 ? 273 GLN   A CB  1 
ATOM   2113 C CG  . GLN   A 1 273 ? -14.12862 -43.39755 9.55563   1.000 29.35430 ? 273 GLN   A CG  1 
ATOM   2114 C CD  . GLN   A 1 273 ? -13.44872 -44.14924 10.66567  1.000 32.33613 ? 273 GLN   A CD  1 
ATOM   2115 O OE1 . GLN   A 1 273 ? -14.10561 -44.72487 11.52884  1.000 36.89113 ? 273 GLN   A OE1 1 
ATOM   2116 N NE2 . GLN   A 1 273 ? -12.12109 -44.11947 10.67533  1.000 37.27717 ? 273 GLN   A NE2 1 
ATOM   2117 N N   . ASN   A 1 274 ? -18.46627 -43.44268 7.92129   1.000 27.61537 ? 274 ASN   A N   1 
ATOM   2118 C CA  . ASN   A 1 274 ? -19.76261 -44.01962 7.60975   1.000 34.87925 ? 274 ASN   A CA  1 
ATOM   2119 C C   . ASN   A 1 274 ? -20.59526 -43.19412 6.64105   1.000 34.52781 ? 274 ASN   A C   1 
ATOM   2120 O O   . ASN   A 1 274 ? -21.58614 -43.71024 6.11263   1.000 30.81015 ? 274 ASN   A O   1 
ATOM   2121 C CB  . ASN   A 1 274 ? -20.57627 -44.21013 8.89055   1.000 34.43463 ? 274 ASN   A CB  1 
ATOM   2122 C CG  . ASN   A 1 274 ? -19.84300 -45.01261 9.94467   1.000 39.25859 ? 274 ASN   A CG  1 
ATOM   2123 O OD1 . ASN   A 1 274 ? -18.75952 -45.54666 9.70767   1.000 44.95136 ? 274 ASN   A OD1 1 
ATOM   2124 N ND2 . ASN   A 1 274 ? -20.42470 -45.07742 11.13667  1.000 42.52603 ? 274 ASN   A ND2 1 
ATOM   2125 N N   . GLY   A 1 275 ? -20.23783 -41.94017 6.39336   1.000 33.63953 ? 275 GLY   A N   1 
ATOM   2126 C CA  . GLY   A 1 275 ? -21.16950 -41.10376 5.66334   1.000 32.46251 ? 275 GLY   A CA  1 
ATOM   2127 C C   . GLY   A 1 275 ? -22.34814 -40.73877 6.55807   1.000 33.23345 ? 275 GLY   A C   1 
ATOM   2128 O O   . GLY   A 1 275 ? -22.32566 -40.92476 7.76919   1.000 34.03267 ? 275 GLY   A O   1 
ATOM   2129 N N   . MET   A 1 276 ? -23.39880 -40.20733 5.93250   1.000 35.33137 ? 276 MET   A N   1 
ATOM   2130 C CA  . MET   A 1 276 ? -24.52915 -39.68741 6.69150   1.000 37.39650 ? 276 MET   A CA  1 
ATOM   2131 C C   . MET   A 1 276 ? -25.73919 -40.61158 6.67957   1.000 41.77752 ? 276 MET   A C   1 
ATOM   2132 O O   . MET   A 1 276 ? -26.66001 -40.42032 7.48968   1.000 39.35240 ? 276 MET   A O   1 
ATOM   2133 C CB  . MET   A 1 276 ? -24.94146 -38.31406 6.16669   1.000 36.70244 ? 276 MET   A CB  1 
ATOM   2134 C CG  . MET   A 1 276 ? -23.99026 -37.21392 6.58900   1.000 33.34053 ? 276 MET   A CG  1 
ATOM   2135 S SD  . MET   A 1 276 ? -24.60403 -35.70781 5.87342   1.000 36.45665 ? 276 MET   A SD  1 
ATOM   2136 C CE  . MET   A 1 276 ? -23.24715 -34.62154 6.19766   1.000 25.26547 ? 276 MET   A CE  1 
ATOM   2137 N N   . ASN   A 1 277 ? -25.75256 -41.60001 5.78947   1.000 43.76440 ? 277 ASN   A N   1 
ATOM   2138 C CA  . ASN   A 1 277 ? -26.77202 -42.63541 5.79040   1.000 43.86438 ? 277 ASN   A CA  1 
ATOM   2139 C C   . ASN   A 1 277 ? -28.14230 -42.02397 5.49947   1.000 40.57887 ? 277 ASN   A C   1 
ATOM   2140 O O   . ASN   A 1 277 ? -29.13268 -42.28733 6.18552   1.000 41.18862 ? 277 ASN   A O   1 
ATOM   2141 C CB  . ASN   A 1 277 ? -26.75482 -43.39530 7.11922   1.000 47.58991 ? 277 ASN   A CB  1 
ATOM   2142 C CG  . ASN   A 1 277 ? -27.41673 -44.74262 7.02826   1.000 55.47727 ? 277 ASN   A CG  1 
ATOM   2143 O OD1 . ASN   A 1 277 ? -27.94832 -45.12316 5.98023   1.000 56.22918 ? 277 ASN   A OD1 1 
ATOM   2144 N ND2 . ASN   A 1 277 ? -27.40927 -45.47388 8.13795   1.000 59.76433 ? 277 ASN   A ND2 1 
ATOM   2145 N N   . GLY   A 1 278 ? -28.17966 -41.16368 4.48252   1.000 37.61257 ? 278 GLY   A N   1 
ATOM   2146 C CA  . GLY   A 1 278 ? -29.41851 -40.59252 4.00343   1.000 37.64187 ? 278 GLY   A CA  1 
ATOM   2147 C C   . GLY   A 1 278 ? -29.96077 -39.43652 4.81069   1.000 40.07066 ? 278 GLY   A C   1 
ATOM   2148 O O   . GLY   A 1 278 ? -31.02020 -38.89823 4.45301   1.000 38.04873 ? 278 GLY   A O   1 
ATOM   2149 N N   . ARG   A 1 279 ? -29.27732 -39.03720 5.88035   1.000 35.34545 ? 279 ARG   A N   1 
ATOM   2150 C CA  . ARG   A 1 279 ? -29.68974 -37.90650 6.69169   1.000 31.27289 ? 279 ARG   A CA  1 
ATOM   2151 C C   . ARG   A 1 279 ? -28.99325 -36.63434 6.21974   1.000 24.45982 ? 279 ARG   A C   1 
ATOM   2152 O O   . ARG   A 1 279 ? -28.07900 -36.65544 5.39752   1.000 26.71764 ? 279 ARG   A O   1 
ATOM   2153 C CB  . ARG   A 1 279 ? -29.39788 -38.17269 8.17337   1.000 30.08356 ? 279 ARG   A CB  1 
ATOM   2154 C CG  . ARG   A 1 279 ? -30.29583 -39.26534 8.76191   1.000 33.64706 ? 279 ARG   A CG  1 
ATOM   2155 C CD  . ARG   A 1 279 ? -29.84091 -39.70887 10.12881  1.000 33.47125 ? 279 ARG   A CD  1 
ATOM   2156 N NE  . ARG   A 1 279 ? -28.49928 -40.28168 10.09535  1.000 37.94889 ? 279 ARG   A NE  1 
ATOM   2157 C CZ  . ARG   A 1 279 ? -28.00265 -41.08607 11.02929  1.000 32.92305 ? 279 ARG   A CZ  1 
ATOM   2158 N NH1 . ARG   A 1 279 ? -28.73468 -41.39745 12.09811  1.000 35.50724 ? 279 ARG   A NH1 1 
ATOM   2159 N NH2 . ARG   A 1 279 ? -26.75724 -41.54165 10.91273  1.000 32.29315 ? 279 ARG   A NH2 1 
ATOM   2160 N N   . THR   A 1 280 ? -29.44047 -35.51184 6.75386   1.000 23.90926 ? 280 THR   A N   1 
ATOM   2161 C CA  . THR   A 1 280 ? -28.86112 -34.22637 6.40208   1.000 22.86182 ? 280 THR   A CA  1 
ATOM   2162 C C   . THR   A 1 280 ? -28.46822 -33.47715 7.66811   1.000 21.81568 ? 280 THR   A C   1 
ATOM   2163 O O   . THR   A 1 280 ? -28.93269 -33.77161 8.77623   1.000 20.08570 ? 280 THR   A O   1 
ATOM   2164 C CB  . THR   A 1 280 ? -29.83623 -33.39518 5.54836   1.000 23.89931 ? 280 THR   A CB  1 
ATOM   2165 O OG1 . THR   A 1 280 ? -31.04248 -33.16919 6.28936   1.000 19.83634 ? 280 THR   A OG1 1 
ATOM   2166 C CG2 . THR   A 1 280 ? -30.16037 -34.14406 4.22456   1.000 21.21947 ? 280 THR   A CG2 1 
ATOM   2167 N N   . ILE   A 1 281 ? -27.57974 -32.51087 7.49296   1.000 17.94668 ? 281 ILE   A N   1 
ATOM   2168 C CA  . ILE   A 1 281 ? -27.16673 -31.61966 8.56131   1.000 13.57445 ? 281 ILE   A CA  1 
ATOM   2169 C C   . ILE   A 1 281 ? -27.35793 -30.21203 8.03840   1.000 19.52575 ? 281 ILE   A C   1 
ATOM   2170 O O   . ILE   A 1 281 ? -26.75562 -29.84735 7.02387   1.000 16.62351 ? 281 ILE   A O   1 
ATOM   2171 C CB  . ILE   A 1 281 ? -25.69350 -31.83083 8.96974   1.000 14.95395 ? 281 ILE   A CB  1 
ATOM   2172 C CG1 . ILE   A 1 281 ? -25.40663 -33.28433 9.37787   1.000 17.43813 ? 281 ILE   A CG1 1 
ATOM   2173 C CG2 . ILE   A 1 281 ? -25.32457 -30.86349 10.08341  1.000 14.79508 ? 281 ILE   A CG2 1 
ATOM   2174 C CD1 . ILE   A 1 281 ? -23.92773 -33.54759 9.88788   1.000 17.10274 ? 281 ILE   A CD1 1 
ATOM   2175 N N   . LEU   A 1 282 ? -28.16349 -29.41313 8.73164   1.000 18.01713 ? 282 LEU   A N   1 
ATOM   2176 C CA  . LEU   A 1 282 ? -28.41431 -28.03632 8.30953   1.000 19.19162 ? 282 LEU   A CA  1 
ATOM   2177 C C   . LEU   A 1 282 ? -28.79184 -27.94975 6.82902   1.000 21.77595 ? 282 LEU   A C   1 
ATOM   2178 O O   . LEU   A 1 282 ? -28.33189 -27.06373 6.10101   1.000 16.26982 ? 282 LEU   A O   1 
ATOM   2179 C CB  . LEU   A 1 282 ? -27.20100 -27.14260 8.62061   1.000 15.44153 ? 282 LEU   A CB  1 
ATOM   2180 C CG  . LEU   A 1 282 ? -27.06892 -26.76731 10.08768  1.000 17.68658 ? 282 LEU   A CG  1 
ATOM   2181 C CD1 . LEU   A 1 282 ? -25.76398 -26.02180 10.33409  1.000 16.75409 ? 282 LEU   A CD1 1 
ATOM   2182 C CD2 . LEU   A 1 282 ? -28.29670 -25.96281 10.58203  1.000 16.59391 ? 282 LEU   A CD2 1 
ATOM   2183 N N   . GLY   A 1 283 ? -29.63990 -28.87675 6.37210   1.000 19.99643 ? 283 GLY   A N   1 
ATOM   2184 C CA  . GLY   A 1 283 ? -30.08779 -28.87108 4.98908   1.000 20.98783 ? 283 GLY   A CA  1 
ATOM   2185 C C   . GLY   A 1 283 ? -29.06193 -29.32612 3.97549   1.000 22.21855 ? 283 GLY   A C   1 
ATOM   2186 O O   . GLY   A 1 283 ? -29.26797 -29.14931 2.76961   1.000 23.41823 ? 283 GLY   A O   1 
ATOM   2187 N N   . SER   A 1 284 ? -27.95893 -29.92363 4.41343   1.000 19.91428 ? 284 SER   A N   1 
ATOM   2188 C CA  . SER   A 1 284 ? -26.93857 -30.39897 3.49690   1.000 19.26977 ? 284 SER   A CA  1 
ATOM   2189 C C   . SER   A 1 284 ? -26.74547 -31.90223 3.67027   1.000 18.73600 ? 284 SER   A C   1 
ATOM   2190 O O   . SER   A 1 284 ? -26.85560 -32.43436 4.77752   1.000 17.01205 ? 284 SER   A O   1 
ATOM   2191 C CB  . SER   A 1 284 ? -25.60975 -29.63226 3.73146   1.000 18.59946 ? 284 SER   A CB  1 
ATOM   2192 O OG  . SER   A 1 284 ? -24.57371 -30.07980 2.86382   1.000 22.24341 ? 284 SER   A OG  1 
ATOM   2193 N N   . ALA   A 1 285 ? -26.47303 -32.60151 2.56908   1.000 18.43628 ? 285 ALA   A N   1 
ATOM   2194 C CA  . ALA   A 1 285 ? -26.04820 -33.98897 2.65860   1.000 20.33369 ? 285 ALA   A CA  1 
ATOM   2195 C C   . ALA   A 1 285 ? -24.53942 -34.14350 2.50575   1.000 19.99481 ? 285 ALA   A C   1 
ATOM   2196 O O   . ALA   A 1 285 ? -24.06184 -35.26703 2.32544   1.000 22.85262 ? 285 ALA   A O   1 
ATOM   2197 C CB  . ALA   A 1 285 ? -26.76344 -34.85042 1.62244   1.000 23.80905 ? 285 ALA   A CB  1 
ATOM   2198 N N   . LEU   A 1 286 ? -23.79249 -33.04016 2.54907   1.000 16.15444 ? 286 LEU   A N   1 
ATOM   2199 C CA  . LEU   A 1 286 ? -22.33014 -33.00055 2.48756   1.000 21.28261 ? 286 LEU   A CA  1 
ATOM   2200 C C   . LEU   A 1 286 ? -21.79461 -32.29693 3.72260   1.000 20.03180 ? 286 LEU   A C   1 
ATOM   2201 O O   . LEU   A 1 286 ? -22.46993 -31.43417 4.29741   1.000 17.81809 ? 286 LEU   A O   1 
ATOM   2202 C CB  . LEU   A 1 286 ? -21.83175 -32.21527 1.26595   1.000 18.90259 ? 286 LEU   A CB  1 
ATOM   2203 C CG  . LEU   A 1 286 ? -22.19988 -32.74422 -0.09365  1.000 25.13314 ? 286 LEU   A CG  1 
ATOM   2204 C CD1 . LEU   A 1 286 ? -21.36144 -32.06231 -1.17475  1.000 22.91692 ? 286 LEU   A CD1 1 
ATOM   2205 C CD2 . LEU   A 1 286 ? -21.91931 -34.25283 -0.02713  1.000 29.68929 ? 286 LEU   A CD2 1 
ATOM   2206 N N   . LEU   A 1 287 ? -20.55351 -32.59991 4.10992   1.000 15.76033 ? 287 LEU   A N   1 
ATOM   2207 C CA  . LEU   A 1 287 ? -19.94587 -31.83564 5.19846   1.000 16.47268 ? 287 LEU   A CA  1 
ATOM   2208 C C   . LEU   A 1 287 ? -19.50048 -30.48414 4.64486   1.000 17.01294 ? 287 LEU   A C   1 
ATOM   2209 O O   . LEU   A 1 287 ? -18.68247 -30.42418 3.72972   1.000 18.24345 ? 287 LEU   A O   1 
ATOM   2210 C CB  . LEU   A 1 287 ? -18.78100 -32.60776 5.83164   1.000 19.42707 ? 287 LEU   A CB  1 
ATOM   2211 C CG  . LEU   A 1 287 ? -19.26064 -33.96303 6.35954   1.000 18.24511 ? 287 LEU   A CG  1 
ATOM   2212 C CD1 . LEU   A 1 287 ? -18.10671 -34.89264 6.81931   1.000 22.81703 ? 287 LEU   A CD1 1 
ATOM   2213 C CD2 . LEU   A 1 287 ? -20.21392 -33.67525 7.49173   1.000 20.58915 ? 287 LEU   A CD2 1 
ATOM   2214 N N   . GLU   A 1 288 ? -20.05044 -29.40389 5.18567   1.000 15.37923 ? 288 GLU   A N   1 
ATOM   2215 C CA  . GLU   A 1 288 ? -19.78287 -28.05207 4.71118   1.000 16.54734 ? 288 GLU   A CA  1 
ATOM   2216 C C   . GLU   A 1 288 ? -18.53486 -27.43913 5.35469   1.000 14.24326 ? 288 GLU   A C   1 
ATOM   2217 O O   . GLU   A 1 288 ? -18.41079 -27.40095 6.58707   1.000 13.15783 ? 288 GLU   A O   1 
ATOM   2218 C CB  . GLU   A 1 288 ? -21.01573 -27.19301 5.00046   1.000 16.40665 ? 288 GLU   A CB  1 
ATOM   2219 C CG  . GLU   A 1 288 ? -20.82086 -25.78200 4.61978   1.000 22.34107 ? 288 GLU   A CG  1 
ATOM   2220 C CD  . GLU   A 1 288 ? -20.77881 -25.56813 3.09669   1.000 31.52421 ? 288 GLU   A CD  1 
ATOM   2221 O OE1 . GLU   A 1 288 ? -20.06043 -24.59598 2.69902   1.000 21.72321 ? 288 GLU   A OE1 1 
ATOM   2222 O OE2 . GLU   A 1 288 ? -21.46045 -26.33450 2.33323   1.000 28.73212 ? 288 GLU   A OE2 1 
ATOM   2223 N N   . ASP   A 1 289 ? -17.63614 -26.89015 4.53485   1.000 11.45115 ? 289 ASP   A N   1 
ATOM   2224 C CA  . ASP   A 1 289 ? -16.40384 -26.31806 5.08580   1.000 13.32866 ? 289 ASP   A CA  1 
ATOM   2225 C C   . ASP   A 1 289 ? -16.20248 -24.82851 4.75472   1.000 13.46448 ? 289 ASP   A C   1 
ATOM   2226 O O   . ASP   A 1 289 ? -15.08544 -24.30953 4.90144   1.000 13.05992 ? 289 ASP   A O   1 
ATOM   2227 C CB  . ASP   A 1 289 ? -15.20921 -27.16473 4.64142   1.000 13.34067 ? 289 ASP   A CB  1 
ATOM   2228 C CG  . ASP   A 1 289 ? -14.70576 -26.84638 3.19242   1.000 15.46647 ? 289 ASP   A CG  1 
ATOM   2229 O OD1 . ASP   A 1 289 ? -15.44712 -26.27468 2.35341   1.000 12.09682 ? 289 ASP   A OD1 1 
ATOM   2230 O OD2 . ASP   A 1 289 ? -13.52416 -27.18464 2.93535   1.000 16.98456 ? 289 ASP   A OD2 1 
ATOM   2231 N N   . GLU   A 1 290 ? -17.25393 -24.09265 4.37168   1.000 12.72000 ? 290 GLU   A N   1 
ATOM   2232 C CA  . GLU   A 1 290 ? -17.04478 -22.68456 4.05675   1.000 12.49270 ? 290 GLU   A CA  1 
ATOM   2233 C C   . GLU   A 1 290 ? -17.66444 -21.75067 5.09379   1.000 13.02422 ? 290 GLU   A C   1 
ATOM   2234 O O   . GLU   A 1 290 ? -17.90837 -20.58421 4.79365   1.000 11.54728 ? 290 GLU   A O   1 
ATOM   2235 C CB  . GLU   A 1 290 ? -17.49799 -22.35715 2.62726   1.000 17.80074 ? 290 GLU   A CB  1 
ATOM   2236 C CG  . GLU   A 1 290 ? -16.63668 -23.11195 1.56716   1.000 13.00897 ? 290 GLU   A CG  1 
ATOM   2237 C CD  . GLU   A 1 290 ? -16.42209 -22.38911 0.22508   1.000 18.21556 ? 290 GLU   A CD  1 
ATOM   2238 O OE1 . GLU   A 1 290 ? -17.21304 -21.45148 -0.08852  1.000 16.05414 ? 290 GLU   A OE1 1 
ATOM   2239 O OE2 . GLU   A 1 290 ? -15.53855 -22.85098 -0.57365  1.000 14.75974 ? 290 GLU   A OE2 1 
ATOM   2240 N N   . PHE   A 1 291 ? -17.82210 -22.21182 6.35291   1.000 11.53520 ? 291 PHE   A N   1 
ATOM   2241 C CA  . PHE   A 1 291 ? -18.15396 -21.33866 7.47822   1.000 8.89362  ? 291 PHE   A CA  1 
ATOM   2242 C C   . PHE   A 1 291 ? -17.01881 -21.41467 8.49729   1.000 10.51326 ? 291 PHE   A C   1 
ATOM   2243 O O   . PHE   A 1 291 ? -16.65765 -22.51603 8.94583   1.000 8.77429  ? 291 PHE   A O   1 
ATOM   2244 C CB  . PHE   A 1 291 ? -19.47242 -21.75886 8.17208   1.000 11.62694 ? 291 PHE   A CB  1 
ATOM   2245 C CG  . PHE   A 1 291 ? -20.68719 -21.63815 7.30861   1.000 12.27987 ? 291 PHE   A CG  1 
ATOM   2246 C CD1 . PHE   A 1 291 ? -21.24867 -20.40742 7.03535   1.000 19.18600 ? 291 PHE   A CD1 1 
ATOM   2247 C CD2 . PHE   A 1 291 ? -21.20720 -22.74472 6.67777   1.000 12.65671 ? 291 PHE   A CD2 1 
ATOM   2248 C CE1 . PHE   A 1 291 ? -22.39794 -20.29558 6.20970   1.000 18.19154 ? 291 PHE   A CE1 1 
ATOM   2249 C CE2 . PHE   A 1 291 ? -22.34323 -22.63454 5.82224   1.000 21.21810 ? 291 PHE   A CE2 1 
ATOM   2250 C CZ  . PHE   A 1 291 ? -22.93034 -21.40685 5.60428   1.000 15.67787 ? 291 PHE   A CZ  1 
ATOM   2251 N N   . THR   A 1 292 ? -16.45159 -20.25608 8.86526   1.000 10.57176 ? 292 THR   A N   1 
ATOM   2252 C CA  . THR   A 1 292 ? -15.43372 -20.23654 9.91301   1.000 11.92924 ? 292 THR   A CA  1 
ATOM   2253 C C   . THR   A 1 292 ? -16.08546 -20.23089 11.28827  1.000 11.54372 ? 292 THR   A C   1 
ATOM   2254 O O   . THR   A 1 292 ? -17.28006 -19.93738 11.41441  1.000 10.32564 ? 292 THR   A O   1 
ATOM   2255 C CB  . THR   A 1 292 ? -14.56811 -18.99774 9.82472   1.000 9.89107  ? 292 THR   A CB  1 
ATOM   2256 O OG1 . THR   A 1 292 ? -15.38326 -17.85274 10.17040  1.000 11.24693 ? 292 THR   A OG1 1 
ATOM   2257 C CG2 . THR   A 1 292 ? -13.95287 -18.85971 8.45412   1.000 9.11493  ? 292 THR   A CG2 1 
ATOM   2258 N N   . PRO   A 1 293 ? -15.31074 -20.52000 12.33652  1.000 13.24122 ? 293 PRO   A N   1 
ATOM   2259 C CA  . PRO   A 1 293 ? -15.84029 -20.36588 13.70929  1.000 9.00402  ? 293 PRO   A CA  1 
ATOM   2260 C C   . PRO   A 1 293 ? -16.42997 -18.97770 13.95950  1.000 14.75758 ? 293 PRO   A C   1 
ATOM   2261 O O   . PRO   A 1 293 ? -17.49747 -18.84442 14.58075  1.000 14.82941 ? 293 PRO   A O   1 
ATOM   2262 C CB  . PRO   A 1 293 ? -14.60092 -20.65063 14.57930  1.000 12.94419 ? 293 PRO   A CB  1 
ATOM   2263 C CG  . PRO   A 1 293 ? -13.76306 -21.61187 13.77392  1.000 13.66094 ? 293 PRO   A CG  1 
ATOM   2264 C CD  . PRO   A 1 293 ? -13.94418 -21.10115 12.32653  1.000 14.82628 ? 293 PRO   A CD  1 
ATOM   2265 N N   . PHE   A 1 294 ? -15.79460 -17.93638 13.40536  1.000 15.20443 ? 294 PHE   A N   1 
ATOM   2266 C CA  . PHE   A 1 294 ? -16.32126 -16.57634 13.50445  1.000 15.66795 ? 294 PHE   A CA  1 
ATOM   2267 C C   . PHE   A 1 294 ? -17.68855 -16.44650 12.85001  1.000 17.71153 ? 294 PHE   A C   1 
ATOM   2268 O O   . PHE   A 1 294 ? -18.60654 -15.85854 13.42957  1.000 16.59966 ? 294 PHE   A O   1 
ATOM   2269 C CB  . PHE   A 1 294 ? -15.37196 -15.58354 12.83474  1.000 20.87280 ? 294 PHE   A CB  1 
ATOM   2270 C CG  . PHE   A 1 294 ? -15.90411 -14.17537 12.83465  1.000 31.61319 ? 294 PHE   A CG  1 
ATOM   2271 C CD1 . PHE   A 1 294 ? -15.85969 -13.40407 13.98516  1.000 32.79518 ? 294 PHE   A CD1 1 
ATOM   2272 C CD2 . PHE   A 1 294 ? -16.54564 -13.65509 11.71053  1.000 31.50744 ? 294 PHE   A CD2 1 
ATOM   2273 C CE1 . PHE   A 1 294 ? -16.38177 -12.10965 13.99447  1.000 34.95537 ? 294 PHE   A CE1 1 
ATOM   2274 C CE2 . PHE   A 1 294 ? -17.08008 -12.37061 11.72220  1.000 34.10061 ? 294 PHE   A CE2 1 
ATOM   2275 C CZ  . PHE   A 1 294 ? -16.99174 -11.60061 12.86727  1.000 28.29880 ? 294 PHE   A CZ  1 
ATOM   2276 N N   . ASP   A 1 295 ? -17.80906 -16.90341 11.59625  1.000 14.30219 ? 295 ASP   A N   1 
ATOM   2277 C CA  . ASP   A 1 295 ? -19.09106 -16.86786 10.89527  1.000 14.19676 ? 295 ASP   A CA  1 
ATOM   2278 C C   . ASP   A 1 295 ? -20.18611 -17.51318 11.72407  1.000 17.64678 ? 295 ASP   A C   1 
ATOM   2279 O O   . ASP   A 1 295 ? -21.33745 -17.05791 11.71799  1.000 15.01601 ? 295 ASP   A O   1 
ATOM   2280 C CB  . ASP   A 1 295 ? -18.98801 -17.61465 9.56395   1.000 11.87801 ? 295 ASP   A CB  1 
ATOM   2281 C CG  . ASP   A 1 295 ? -18.02508 -16.95805 8.61365   1.000 15.69195 ? 295 ASP   A CG  1 
ATOM   2282 O OD1 . ASP   A 1 295 ? -17.71624 -15.78416 8.87476   1.000 13.39542 ? 295 ASP   A OD1 1 
ATOM   2283 O OD2 . ASP   A 1 295 ? -17.52574 -17.63375 7.67800   1.000 13.09861 ? 295 ASP   A OD2 1 
ATOM   2284 N N   . VAL   A 1 296 ? -19.85255 -18.60702 12.41308  1.000 12.51626 ? 296 VAL   A N   1 
ATOM   2285 C CA  . VAL   A 1 296 ? -20.87577 -19.34459 13.14333  1.000 12.73873 ? 296 VAL   A CA  1 
ATOM   2286 C C   . VAL   A 1 296 ? -21.31156 -18.55954 14.36938  1.000 16.89635 ? 296 VAL   A C   1 
ATOM   2287 O O   . VAL   A 1 296 ? -22.50612 -18.39505 14.63075  1.000 18.62487 ? 296 VAL   A O   1 
ATOM   2288 C CB  . VAL   A 1 296 ? -20.37710 -20.75318 13.51537  1.000 10.71514 ? 296 VAL   A CB  1 
ATOM   2289 C CG1 . VAL   A 1 296 ? -21.37783 -21.40991 14.48324  1.000 14.39775 ? 296 VAL   A CG1 1 
ATOM   2290 C CG2 . VAL   A 1 296 ? -20.20007 -21.63056 12.25887  1.000 11.56528 ? 296 VAL   A CG2 1 
ATOM   2291 N N   . VAL   A 1 297 ? -20.34933 -18.06892 15.14110  1.000 18.69641 ? 297 VAL   A N   1 
ATOM   2292 C CA  . VAL   A 1 297 ? -20.65985 -17.18796 16.26086  1.000 18.19762 ? 297 VAL   A CA  1 
ATOM   2293 C C   . VAL   A 1 297 ? -21.43628 -15.96161 15.79147  1.000 23.76689 ? 297 VAL   A C   1 
ATOM   2294 O O   . VAL   A 1 297 ? -22.42296 -15.56828 16.42729  1.000 26.62852 ? 297 VAL   A O   1 
ATOM   2295 C CB  . VAL   A 1 297 ? -19.37219 -16.77580 16.98591  1.000 17.67312 ? 297 VAL   A CB  1 
ATOM   2296 C CG1 . VAL   A 1 297 ? -19.68026 -15.67353 17.99448  1.000 23.69484 ? 297 VAL   A CG1 1 
ATOM   2297 C CG2 . VAL   A 1 297 ? -18.78545 -17.96991 17.66944  1.000 19.13608 ? 297 VAL   A CG2 1 
ATOM   2298 N N   . ARG   A 1 298 ? -20.95466 -15.29120 14.72117  1.000 21.43068 ? 298 ARG   A N   1 
ATOM   2299 C CA  . ARG   A 1 298 ? -21.75145 -14.21649 14.10654  1.000 26.01256 ? 298 ARG   A CA  1 
ATOM   2300 C C   . ARG   A 1 298 ? -23.21590 -14.56969 13.90768  1.000 29.15423 ? 298 ARG   A C   1 
ATOM   2301 O O   . ARG   A 1 298 ? -24.06881 -13.83331 14.43845  1.000 34.27798 ? 298 ARG   A O   1 
ATOM   2302 C CB  . ARG   A 1 298 ? -21.19831 -13.61735 12.83529  1.000 27.44632 ? 298 ARG   A CB  1 
ATOM   2303 C CG  . ARG   A 1 298 ? -22.22777 -12.43370 12.23164  1.000 37.46938 ? 298 ARG   A CG  1 
ATOM   2304 C CD  . ARG   A 1 298 ? -21.57852 -11.73975 10.81544  1.000 38.20789 ? 298 ARG   A CD  1 
ATOM   2305 N NE  . ARG   A 1 298 ? -21.19008 -12.34643 9.44369   1.000 37.16163 ? 298 ARG   A NE  1 
ATOM   2306 C CZ  . ARG   A 1 298 ? -21.81684 -12.57904 8.30612   1.000 21.83575 ? 298 ARG   A CZ  1 
ATOM   2307 N NH1 . ARG   A 1 298 ? -22.62283 -11.74937 7.74532   1.000 25.40007 ? 298 ARG   A NH1 1 
ATOM   2308 N NH2 . ARG   A 1 298 ? -21.24613 -13.44248 7.45254   1.000 26.51711 ? 298 ARG   A NH2 1 
ATOM   2309 N N   . GLN   A 1 299 ? -23.50312 -15.63036 13.21948  1.000 26.54256 ? 299 GLN   A N   1 
ATOM   2310 C CA  . GLN   A 1 299 ? -24.87214 -15.89129 12.83744  1.000 26.55194 ? 299 GLN   A CA  1 
ATOM   2311 C C   . GLN   A 1 299 ? -25.67387 -16.52899 13.96726  1.000 31.66165 ? 299 GLN   A C   1 
ATOM   2312 O O   . GLN   A 1 299 ? -26.87683 -16.26717 14.09199  1.000 38.38432 ? 299 GLN   A O   1 
ATOM   2313 C CB  . GLN   A 1 299 ? -24.88665 -16.77944 11.58868  1.000 24.84410 ? 299 GLN   A CB  1 
ATOM   2314 C CG  . GLN   A 1 299 ? -26.15477 -16.78819 10.87205  1.000 20.91041 ? 299 GLN   A CG  1 
ATOM   2315 C CD  . GLN   A 1 299 ? -26.08354 -17.47743 9.54596   1.000 16.26513 ? 299 GLN   A CD  1 
ATOM   2316 O OE1 . GLN   A 1 299 ? -27.10627 -17.95033 9.06971   1.000 15.53609 ? 299 GLN   A OE1 1 
ATOM   2317 N NE2 . GLN   A 1 299 ? -24.89847 -17.51368 8.90936   1.000 14.93002 ? 299 GLN   A NE2 1 
ATOM   2318 N N   . CYS   A 1 300 ? -25.04155 -17.35518 14.80362  1.000 28.82710 ? 300 CYS   A N   1 
ATOM   2319 C CA  . CYS   A 1 300 ? -25.71300 -17.94982 15.94997  1.000 29.82986 ? 300 CYS   A CA  1 
ATOM   2320 C C   . CYS   A 1 300 ? -25.64308 -17.05631 17.21116  1.000 39.10380 ? 300 CYS   A C   1 
ATOM   2321 O O   . CYS   A 1 300 ? -25.80785 -17.56656 18.32300  1.000 49.04413 ? 300 CYS   A O   1 
ATOM   2322 C CB  . CYS   A 1 300 ? -25.14596 -19.35296 16.23642  1.000 27.31158 ? 300 CYS   A CB  1 
ATOM   2323 S SG  . CYS   A 1 300 ? -25.16331 -20.59425 14.86646  1.000 26.12665 ? 300 CYS   A SG  1 
ATOM   2324 N N   . SER   A 1 301 ? -25.40228 -15.74015 17.05548  1.000 48.06517 ? 301 SER   A N   1 
ATOM   2325 C CA  . SER   A 1 301 ? -25.40036 -14.76486 18.15561  1.000 50.08383 ? 301 SER   A CA  1 
ATOM   2326 C C   . SER   A 1 301 ? -25.82669 -13.35522 17.71673  1.000 55.73783 ? 301 SER   A C   1 
ATOM   2327 O O   . SER   A 1 301 ? -26.37850 -12.59655 18.52531  1.000 58.51029 ? 301 SER   A O   1 
ATOM   2328 C CB  . SER   A 1 301 ? -24.02540 -14.69674 18.83280  1.000 53.40236 ? 301 SER   A CB  1 
ATOM   2329 O OG  . SER   A 1 301 ? -23.90406 -13.51666 19.61316  1.000 61.40902 ? 301 SER   A OG  1 
ATOM   2330 N N   . GLY   A 1 302 ? -25.55663 -12.97471 16.46375  1.000 51.07888 ? 302 GLY   A N   1 
ATOM   2331 C CA  . GLY   A 1 302 ? -26.27780 -11.86104 15.87045  1.000 52.62842 ? 302 GLY   A CA  1 
ATOM   2332 C C   . GLY   A 1 302 ? -25.63571 -10.49334 15.72586  1.000 61.33608 ? 302 GLY   A C   1 
ATOM   2333 O O   . GLY   A 1 302 ? -26.33613 -9.48289  15.85885  1.000 56.01070 ? 302 GLY   A O   1 
ATOM   2334 N N   . VAL   A 1 303 ? -24.32661 -10.43825 15.44872  1.000 66.85988 ? 303 VAL   A N   1 
ATOM   2335 C CA  . VAL   A 1 303 ? -23.60043 -9.16705  15.40775  1.000 72.86231 ? 303 VAL   A CA  1 
ATOM   2336 C C   . VAL   A 1 303 ? -23.98436 -8.37546  14.15258  1.000 71.83344 ? 303 VAL   A C   1 
ATOM   2337 O O   . VAL   A 1 303 ? -24.26394 -8.94510  13.08618  1.000 64.08689 ? 303 VAL   A O   1 
ATOM   2338 C CB  . VAL   A 1 303 ? -22.07990 -9.43042  15.48315  1.000 71.45390 ? 303 VAL   A CB  1 
ATOM   2339 C CG1 . VAL   A 1 303 ? -21.26128 -8.14598  15.28450  1.000 77.32133 ? 303 VAL   A CG1 1 
ATOM   2340 C CG2 . VAL   A 1 303 ? -21.71457 -10.11268 16.80634  1.000 66.71845 ? 303 VAL   A CG2 1 
ATOM   2341 N N   . THR   A 1 304 ? -24.02579 -7.04515  14.28751  1.000 75.44021 ? 304 THR   A N   1 
ATOM   2342 C CA  . THR   A 1 304 ? -24.36175 -6.11577  13.20600  1.000 70.47455 ? 304 THR   A CA  1 
ATOM   2343 C C   . THR   A 1 304 ? -23.16267 -5.22275  12.87879  1.000 83.56004 ? 304 THR   A C   1 
ATOM   2344 O O   . THR   A 1 304 ? -22.08154 -5.33762  13.47129  1.000 84.24324 ? 304 THR   A O   1 
ATOM   2345 C CB  . THR   A 1 304 ? -25.57916 -5.25032  13.56209  1.000 57.64285 ? 304 THR   A CB  1 
ATOM   2346 O OG1 . THR   A 1 304 ? -25.40248 -4.67450  14.86345  1.000 69.16167 ? 304 THR   A OG1 1 
ATOM   2347 C CG2 . THR   A 1 304 ? -26.85560 -6.07518  13.55142  1.000 39.97209 ? 304 THR   A CG2 1 
ATOM   2348 N N   . PHE   A 1 305 ? -23.37428 -4.32270  11.91410  1.000 85.71179 ? 305 PHE   A N   1 
ATOM   2349 C CA  . PHE   A 1 305 ? -22.31859 -3.47544  11.36528  1.000 88.83554 ? 305 PHE   A CA  1 
ATOM   2350 C C   . PHE   A 1 305 ? -22.91087 -2.12632  10.98099  1.000 88.84111 ? 305 PHE   A C   1 
ATOM   2351 O O   . PHE   A 1 305 ? -23.98365 -2.06520  10.37064  1.000 90.36498 ? 305 PHE   A O   1 
ATOM   2352 C CB  . PHE   A 1 305 ? -21.64467 -4.14993  10.15343  1.000 84.80378 ? 305 PHE   A CB  1 
ATOM   2353 C CG  . PHE   A 1 305 ? -21.32292 -5.60130  10.38747  1.000 83.75103 ? 305 PHE   A CG  1 
ATOM   2354 C CD1 . PHE   A 1 305 ? -20.14949 -5.96515  11.04295  1.000 81.19019 ? 305 PHE   A CD1 1 
ATOM   2355 C CD2 . PHE   A 1 305 ? -22.22099 -6.59750  10.00685  1.000 81.97186 ? 305 PHE   A CD2 1 
ATOM   2356 C CE1 . PHE   A 1 305 ? -19.86152 -7.29388  11.29785  1.000 81.74552 ? 305 PHE   A CE1 1 
ATOM   2357 C CE2 . PHE   A 1 305 ? -21.94645 -7.93385  10.25794  1.000 81.34021 ? 305 PHE   A CE2 1 
ATOM   2358 C CZ  . PHE   A 1 305 ? -20.76518 -8.28211  10.91301  1.000 84.25109 ? 305 PHE   A CZ  1 
ATOM   2359 N N   . GLN   A 1 306 ? -22.21495 -1.05337  11.34711  1.000 83.27361 ? 306 GLN   A N   1 
ATOM   2360 C CA  . GLN   A 1 306 ? -22.70245 0.29870   11.09458  1.000 84.30948 ? 306 GLN   A CA  1 
ATOM   2361 C C   . GLN   A 1 306 ? -21.56228 1.23196   10.68248  1.000 74.27326 ? 306 GLN   A C   1 
ATOM   2362 O O   . GLN   A 1 306 ? -21.16454 1.26818   9.51573   1.000 65.20548 ? 306 GLN   A O   1 
ATOM   2363 C CB  . GLN   A 1 306 ? -23.41993 0.84398   12.33630  1.000 86.33451 ? 306 GLN   A CB  1 
ATOM   2364 C CG  . GLN   A 1 306 ? -24.37264 2.00507   12.05891  1.000 86.45057 ? 306 GLN   A CG  1 
ATOM   2365 C CD  . GLN   A 1 306 ? -25.25554 2.33199   13.25113  1.000 84.37048 ? 306 GLN   A CD  1 
ATOM   2366 O OE1 . GLN   A 1 306 ? -25.01697 1.84870   14.35769  1.000 88.96406 ? 306 GLN   A OE1 1 
ATOM   2367 N NE2 . GLN   A 1 306 ? -26.27526 3.16274   13.03401  1.000 75.41754 ? 306 GLN   A NE2 1 
HETATM 2368 N N1  . A1ASG B 2 .   ? -14.37576 -14.49453 -14.58287 1.000 15.37238 ? 401 A1ASG A N1  1 
HETATM 2369 N N3  . A1ASG B 2 .   ? -13.85266 -10.18069 -16.82934 1.000 18.13665 ? 401 A1ASG A N3  1 
HETATM 2370 C C4  . A1ASG B 2 .   ? -15.84055 -16.22584 -18.85535 1.000 33.36734 ? 401 A1ASG A C4  1 
HETATM 2371 C C5  . A1ASG B 2 .   ? -15.05449 -15.26364 -19.52065 1.000 32.80293 ? 401 A1ASG A C5  1 
HETATM 2372 C C6  . A1ASG B 2 .   ? -14.30576 -14.36460 -18.81908 1.000 29.74132 ? 401 A1ASG A C6  1 
HETATM 2373 C C7  . A1ASG B 2 .   ? -13.57573 -13.44317 -16.58838 1.000 19.35523 ? 401 A1ASG A C7  1 
HETATM 2374 C C8  . A1ASG B 2 .   ? -13.62753 -13.55654 -15.20019 1.000 18.06185 ? 401 A1ASG A C8  1 
HETATM 2375 C C10 . A1ASG B 2 .   ? -12.67282 -12.37947 -17.23722 1.000 20.56566 ? 401 A1ASG A C10 1 
HETATM 2376 C C13 . A1ASG B 2 .   ? -9.00622  -13.24728 -17.86917 1.000 23.96254 ? 401 A1ASG A C13 1 
HETATM 2377 C C15 . A1ASG B 2 .   ? -7.34659  -13.19133 -19.65673 1.000 33.88161 ? 401 A1ASG A C15 1 
HETATM 2378 C C17 . A1ASG B 2 .   ? -6.39553  -12.99365 -18.49158 1.000 27.62330 ? 401 A1ASG A C17 1 
HETATM 2379 C C20 . A1ASG B 2 .   ? -9.62468  -15.65348 -17.99732 1.000 27.27940 ? 401 A1ASG A C20 1 
HETATM 2380 C C21 . A1ASG B 2 .   ? -9.64362  -17.07446 -18.56710 1.000 28.13860 ? 401 A1ASG A C21 1 
HETATM 2381 C C22 . A1ASG B 2 .   ? -10.83061 -17.38575 -19.55202 1.000 30.85021 ? 401 A1ASG A C22 1 
HETATM 2382 C C24 . A1ASG B 2 .   ? -11.94020 -18.04671 -18.72189 1.000 25.10459 ? 401 A1ASG A C24 1 
HETATM 2383 C C26 . A1ASG B 2 .   ? -7.19482  -18.03361 -18.56804 1.000 33.18749 ? 401 A1ASG A C26 1 
HETATM 2384 C C1  . A1ASG B 2 .   ? -14.31420 -14.37494 -17.38862 1.000 25.82177 ? 401 A1ASG A C1  1 
HETATM 2385 C C11 . A1ASG B 2 .   ? -12.79454 -10.92432 -16.74284 1.000 20.49752 ? 401 A1ASG A C11 1 
HETATM 2386 C C12 . A1ASG B 2 .   ? -10.34402 -12.53772 -18.10443 1.000 24.86883 ? 401 A1ASG A C12 1 
HETATM 2387 C C14 . A1ASG B 2 .   ? -7.82405  -12.45238 -18.42665 1.000 24.93249 ? 401 A1ASG A C14 1 
HETATM 2388 C C16 . A1ASG B 2 .   ? -8.13884  -14.48013 -19.77748 1.000 28.82345 ? 401 A1ASG A C16 1 
HETATM 2389 C C18 . A1ASG B 2 .   ? -5.26483  -11.99018 -18.68831 1.000 30.74191 ? 401 A1ASG A C18 1 
HETATM 2390 C C19 . A1ASG B 2 .   ? -5.91003  -14.17225 -17.66013 1.000 24.64758 ? 401 A1ASG A C19 1 
HETATM 2391 C C2  . A1ASG B 2 .   ? -15.11458 -15.35817 -16.72814 1.000 25.78046 ? 401 A1ASG A C2  1 
HETATM 2392 C C23 . A1ASG B 2 .   ? -10.40100 -18.35318 -20.66364 1.000 29.84333 ? 401 A1ASG A C23 1 
HETATM 2393 C C25 . A1ASG B 2 .   ? -11.52217 -16.17489 -20.20031 1.000 30.89727 ? 401 A1ASG A C25 1 
HETATM 2394 C C27 . A1ASG B 2 .   ? -7.13259  -19.01251 -17.37365 1.000 36.05234 ? 401 A1ASG A C27 1 
HETATM 2395 C C3  . A1ASG B 2 .   ? -15.87128 -16.29012 -17.48930 1.000 27.86877 ? 401 A1ASG A C3  1 
HETATM 2396 C C9  . A1ASG B 2 .   ? -15.09680 -15.33588 -15.30382 1.000 21.07900 ? 401 A1ASG A C9  1 
HETATM 2397 F F1  . A1ASG B 2 .   ? -7.91999  -20.08529 -17.49129 1.000 36.41595 ? 401 A1ASG A F1  1 
HETATM 2398 F F2  . A1ASG B 2 .   ? -7.40652  -18.46174 -16.19666 1.000 30.05384 ? 401 A1ASG A F2  1 
HETATM 2399 F F3  . A1ASG B 2 .   ? -5.88333  -19.48243 -17.27732 1.000 41.94300 ? 401 A1ASG A F3  1 
HETATM 2400 N N2  . A1ASG B 2 .   ? -11.28373 -12.85711 -17.22536 1.000 23.52835 ? 401 A1ASG A N2  1 
HETATM 2401 N N4  . A1ASG B 2 .   ? -8.95691  -14.56587 -18.54254 1.000 25.66658 ? 401 A1ASG A N4  1 
HETATM 2402 N N5  . A1ASG B 2 .   ? -8.26671  -17.32157 -18.98869 1.000 40.04005 ? 401 A1ASG A N5  1 
HETATM 2403 O O1  . A1ASG B 2 .   ? -10.55727 -11.71744 -19.02584 1.000 31.99785 ? 401 A1ASG A O1  1 
HETATM 2404 O O2  . A1ASG B 2 .   ? -10.28561 -15.58119 -16.97115 1.000 20.07774 ? 401 A1ASG A O2  1 
HETATM 2405 O O3  . A1ASG B 2 .   ? -6.16054  -17.94720 -19.19754 1.000 42.69496 ? 401 A1ASG A O3  1 
HETATM 2406 O O   . HOH   C 3 .   ? -25.68676 -19.14140 19.24309  1.000 37.38362 ? 501 HOH   A O   1 
HETATM 2407 O O   . HOH   C 3 .   ? -5.19934  -28.27310 4.00630   1.000 39.75042 ? 502 HOH   A O   1 
HETATM 2408 O O   . HOH   C 3 .   ? -19.42554 -13.55225 7.68298   1.000 33.75408 ? 503 HOH   A O   1 
HETATM 2409 O O   . HOH   C 3 .   ? -0.56822  -18.31136 -21.05167 1.000 37.55427 ? 504 HOH   A O   1 
HETATM 2410 O O   . HOH   C 3 .   ? 2.98296   -0.48573  -2.88954  1.000 42.80438 ? 505 HOH   A O   1 
HETATM 2411 O O   . HOH   C 3 .   ? 1.22198   -18.40037 -10.97965 1.000 32.48275 ? 506 HOH   A O   1 
HETATM 2412 O O   . HOH   C 3 .   ? -7.44536  -25.24377 8.01266   1.000 30.41601 ? 507 HOH   A O   1 
HETATM 2413 O O   . HOH   C 3 .   ? -3.51617  -24.11395 -6.52379  1.000 19.32175 ? 508 HOH   A O   1 
HETATM 2414 O O   . HOH   C 3 .   ? 5.23052   -6.46343  -13.85672 1.000 30.53436 ? 509 HOH   A O   1 
HETATM 2415 O O   . HOH   C 3 .   ? -19.46496 -20.42611 0.68026   1.000 33.21879 ? 510 HOH   A O   1 
HETATM 2416 O O   . HOH   C 3 .   ? 0.36090   1.25495   -2.93868  1.000 37.32486 ? 511 HOH   A O   1 
HETATM 2417 O O   . HOH   C 3 .   ? -19.50208 -23.41142 0.26906   1.000 27.96855 ? 512 HOH   A O   1 
HETATM 2418 O O   . HOH   C 3 .   ? -23.01121 -27.98667 2.08599   1.000 27.03452 ? 513 HOH   A O   1 
HETATM 2419 O O   . HOH   C 3 .   ? -10.57265 -43.90345 9.00293   1.000 35.97495 ? 514 HOH   A O   1 
HETATM 2420 O O   . HOH   C 3 .   ? -25.289   -2.563    8.540     1.000 45.25831 ? 515 HOH   A O   1 
HETATM 2421 O O   . HOH   C 3 .   ? -12.47176 8.94185   -17.82503 1.000 31.40762 ? 516 HOH   A O   1 
HETATM 2422 O O   . HOH   C 3 .   ? -13.70545 -21.59275 -17.28230 1.000 24.89147 ? 517 HOH   A O   1 
HETATM 2423 O O   . HOH   C 3 .   ? -18.38507 -33.42573 25.41895  1.000 24.54585 ? 518 HOH   A O   1 
HETATM 2424 O O   . HOH   C 3 .   ? -6.24837  -19.90698 19.87502  1.000 45.00425 ? 519 HOH   A O   1 
HETATM 2425 O O   . HOH   C 3 .   ? 3.28885   -12.56486 -13.96906 1.000 27.40060 ? 520 HOH   A O   1 
HETATM 2426 O O   . HOH   C 3 .   ? -9.34391  1.98357   8.28209   1.000 28.27829 ? 521 HOH   A O   1 
HETATM 2427 O O   . HOH   C 3 .   ? -7.42570  -23.73962 5.41620   1.000 21.92949 ? 522 HOH   A O   1 
HETATM 2428 O O   . HOH   C 3 .   ? -1.29731  8.47179   -26.22144 1.000 29.19283 ? 523 HOH   A O   1 
HETATM 2429 O O   . HOH   C 3 .   ? -1.69236  -3.41574  -27.12950 1.000 41.43496 ? 524 HOH   A O   1 
HETATM 2430 O O   . HOH   C 3 .   ? -15.44352 -42.02673 16.36452  1.000 35.12961 ? 525 HOH   A O   1 
HETATM 2431 O O   . HOH   C 3 .   ? -24.94590 -11.92100 -11.20792 1.000 31.36811 ? 526 HOH   A O   1 
HETATM 2432 O O   . HOH   C 3 .   ? -14.93190 -32.38965 1.72749   1.000 27.69242 ? 527 HOH   A O   1 
HETATM 2433 O O   . HOH   C 3 .   ? -9.87313  9.56677   -18.69671 1.000 28.43515 ? 528 HOH   A O   1 
HETATM 2434 O O   . HOH   C 3 .   ? -6.21366  -18.63399 18.06601  1.000 41.08221 ? 529 HOH   A O   1 
HETATM 2435 O O   . HOH   C 3 .   ? -23.69283 -43.37980 4.82529   1.000 38.02675 ? 530 HOH   A O   1 
HETATM 2436 O O   . HOH   C 3 .   ? -7.40591  13.92060  -7.04816  1.000 32.15333 ? 531 HOH   A O   1 
HETATM 2437 O O   . HOH   C 3 .   ? -17.41634 -5.59186  -6.59366  1.000 13.16411 ? 532 HOH   A O   1 
HETATM 2438 O O   . HOH   C 3 .   ? -16.23379 -34.41627 3.49972   1.000 23.98790 ? 533 HOH   A O   1 
HETATM 2439 O O   . HOH   C 3 .   ? -1.84074  -34.21690 15.94349  1.000 42.68163 ? 534 HOH   A O   1 
HETATM 2440 O O   . HOH   C 3 .   ? -22.28815 -16.05660 -12.62232 1.000 22.82409 ? 535 HOH   A O   1 
HETATM 2441 O O   . HOH   C 3 .   ? -17.25677 -30.42355 1.63845   1.000 38.25185 ? 536 HOH   A O   1 
HETATM 2442 O O   . HOH   C 3 .   ? -10.95266 -6.34826  11.42426  1.000 44.47490 ? 537 HOH   A O   1 
HETATM 2443 O O   . HOH   C 3 .   ? 1.25736   -15.72561 -8.82776  1.000 26.18377 ? 538 HOH   A O   1 
HETATM 2444 O O   . HOH   C 3 .   ? -11.03100 -21.29683 9.14775   1.000 15.41035 ? 539 HOH   A O   1 
HETATM 2445 O O   . HOH   C 3 .   ? -3.68690  -27.42703 9.54416   1.000 28.61196 ? 540 HOH   A O   1 
HETATM 2446 O O   . HOH   C 3 .   ? 1.70449   8.00627   -20.44293 1.000 29.76888 ? 541 HOH   A O   1 
HETATM 2447 O O   . HOH   C 3 .   ? -20.83074 -38.85529 14.11101  1.000 26.63555 ? 542 HOH   A O   1 
HETATM 2448 O O   . HOH   C 3 .   ? -20.01520 3.58165   -0.27738  1.000 20.50261 ? 543 HOH   A O   1 
HETATM 2449 O O   . HOH   C 3 .   ? -15.52709 -21.12642 18.81140  1.000 23.26441 ? 544 HOH   A O   1 
HETATM 2450 O O   . HOH   C 3 .   ? -11.08567 -32.99786 0.64697   1.000 31.25826 ? 545 HOH   A O   1 
HETATM 2451 O O   . HOH   C 3 .   ? 2.39516   5.28534   -19.25656 1.000 25.74315 ? 546 HOH   A O   1 
HETATM 2452 O O   . HOH   C 3 .   ? -24.94018 -37.61047 1.54094   1.000 36.12282 ? 547 HOH   A O   1 
HETATM 2453 O O   . HOH   C 3 .   ? -2.07236  -24.51310 -8.97388  1.000 26.77205 ? 548 HOH   A O   1 
HETATM 2454 O O   . HOH   C 3 .   ? -8.15760  -41.52678 20.02960  1.000 39.66556 ? 549 HOH   A O   1 
HETATM 2455 O O   . HOH   C 3 .   ? -14.75713 -10.35141 -19.46147 1.000 31.25057 ? 550 HOH   A O   1 
HETATM 2456 O O   . HOH   C 3 .   ? -12.90977 -4.34155  8.64702   1.000 27.42389 ? 551 HOH   A O   1 
HETATM 2457 O O   . HOH   C 3 .   ? -16.85289 -13.64204 6.13293   1.000 18.24774 ? 552 HOH   A O   1 
HETATM 2458 O O   . HOH   C 3 .   ? 0.16082   -20.12289 -13.10389 1.000 25.37752 ? 553 HOH   A O   1 
HETATM 2459 O O   . HOH   C 3 .   ? -3.46653  -23.49207 13.16801  1.000 20.09468 ? 554 HOH   A O   1 
HETATM 2460 O O   . HOH   C 3 .   ? -29.84101 -18.73490 13.75226  1.000 31.91168 ? 555 HOH   A O   1 
HETATM 2461 O O   . HOH   C 3 .   ? -3.36004  -21.57329 20.36518  1.000 29.70778 ? 556 HOH   A O   1 
HETATM 2462 O O   . HOH   C 3 .   ? -28.79987 -20.35258 14.45188  1.000 37.03433 ? 557 HOH   A O   1 
HETATM 2463 O O   . HOH   C 3 .   ? -11.46871 -27.01485 -4.88769  1.000 20.49271 ? 558 HOH   A O   1 
HETATM 2464 O O   . HOH   C 3 .   ? -12.87306 -36.95456 1.66970   1.000 27.31194 ? 559 HOH   A O   1 
HETATM 2465 O O   . HOH   C 3 .   ? -22.09625 -13.00538 -11.26441 1.000 19.77684 ? 560 HOH   A O   1 
HETATM 2466 O O   . HOH   C 3 .   ? -16.46057 -21.86571 -9.22823  1.000 15.53602 ? 561 HOH   A O   1 
HETATM 2467 O O   . HOH   C 3 .   ? -31.14193 -33.42248 10.23418  1.000 31.24401 ? 562 HOH   A O   1 
HETATM 2468 O O   . HOH   C 3 .   ? 1.94485   -16.47372 -21.17589 1.000 39.00456 ? 563 HOH   A O   1 
HETATM 2469 O O   . HOH   C 3 .   ? 1.69920   -12.21477 -16.23634 1.000 25.36192 ? 564 HOH   A O   1 
HETATM 2470 O O   . HOH   C 3 .   ? -17.71222 -5.14450  -16.99608 1.000 17.75658 ? 565 HOH   A O   1 
HETATM 2471 O O   . HOH   C 3 .   ? -27.37278 -8.50205  18.15188  1.000 48.37179 ? 566 HOH   A O   1 
HETATM 2472 O O   . HOH   C 3 .   ? -14.83991 -20.86212 -2.33241  1.000 12.61187 ? 567 HOH   A O   1 
HETATM 2473 O O   . HOH   C 3 .   ? -25.41309 -22.58147 26.15282  1.000 42.08584 ? 568 HOH   A O   1 
HETATM 2474 O O   . HOH   C 3 .   ? -1.14515  -19.24537 4.16782   1.000 11.61107 ? 569 HOH   A O   1 
HETATM 2475 O O   . HOH   C 3 .   ? -28.90910 -28.96846 20.48033  1.000 21.79649 ? 570 HOH   A O   1 
HETATM 2476 O O   . HOH   C 3 .   ? -9.71193  -6.62094  8.78363   1.000 27.82893 ? 571 HOH   A O   1 
HETATM 2477 O O   . HOH   C 3 .   ? -8.25521  3.50721   -24.86603 1.000 44.93001 ? 572 HOH   A O   1 
HETATM 2478 O O   . HOH   C 3 .   ? -19.86089 7.96935   -5.44536  1.000 26.31998 ? 573 HOH   A O   1 
HETATM 2479 O O   . HOH   C 3 .   ? -6.08735  -6.45883  0.09433   1.000 15.23712 ? 574 HOH   A O   1 
HETATM 2480 O O   . HOH   C 3 .   ? 1.37852   -13.12561 -4.37156  1.000 10.79570 ? 575 HOH   A O   1 
HETATM 2481 O O   . HOH   C 3 .   ? -11.44490 -6.19553  -25.83530 1.000 41.60888 ? 576 HOH   A O   1 
HETATM 2482 O O   . HOH   C 3 .   ? -0.00000  -8.01996  0.00000   0.50  16.46657 ? 577 HOH   A O   1 
HETATM 2483 O O   . HOH   C 3 .   ? -6.07457  -10.82551 7.19134   1.000 39.10866 ? 578 HOH   A O   1 
HETATM 2484 O O   . HOH   C 3 .   ? -28.72365 -2.01912  -3.57675  1.000 17.65590 ? 579 HOH   A O   1 
HETATM 2485 O O   . HOH   C 3 .   ? -31.23994 -30.66422 7.69238   1.000 28.47241 ? 580 HOH   A O   1 
HETATM 2486 O O   . HOH   C 3 .   ? -14.83992 -15.32948 9.25390   1.000 19.73114 ? 581 HOH   A O   1 
HETATM 2487 O O   . HOH   C 3 .   ? -8.52717  -25.59892 24.19953  1.000 30.48839 ? 582 HOH   A O   1 
HETATM 2488 O O   . HOH   C 3 .   ? -8.41783  -25.53948 -13.00573 1.000 26.04345 ? 583 HOH   A O   1 
HETATM 2489 O O   . HOH   C 3 .   ? -6.50817  -16.70126 -6.61075  1.000 9.98573  ? 584 HOH   A O   1 
HETATM 2490 O O   . HOH   C 3 .   ? -21.77262 -10.75642 -18.51585 1.000 33.01138 ? 585 HOH   A O   1 
HETATM 2491 O O   . HOH   C 3 .   ? 5.18748   -0.78405  -9.96714  1.000 37.62117 ? 586 HOH   A O   1 
HETATM 2492 O O   . HOH   C 3 .   ? -15.41369 -1.94920  -24.13598 1.000 40.61451 ? 587 HOH   A O   1 
HETATM 2493 O O   . HOH   C 3 .   ? -18.09679 -24.80734 7.44925   1.000 10.56709 ? 588 HOH   A O   1 
HETATM 2494 O O   . HOH   C 3 .   ? -1.54907  6.04834   -9.87824  1.000 24.83581 ? 589 HOH   A O   1 
HETATM 2495 O O   . HOH   C 3 .   ? -7.34034  -6.44570  9.89165   1.000 35.41261 ? 590 HOH   A O   1 
HETATM 2496 O O   . HOH   C 3 .   ? -20.21628 -36.13602 19.99019  1.000 29.31958 ? 591 HOH   A O   1 
HETATM 2497 O O   . HOH   C 3 .   ? -3.02008  -1.05154  -4.47489  1.000 22.18844 ? 592 HOH   A O   1 
HETATM 2498 O O   . HOH   C 3 .   ? -15.66901 14.58168  -4.12896  1.000 30.24210 ? 593 HOH   A O   1 
HETATM 2499 O O   . HOH   C 3 .   ? 4.66271   -3.34074  -6.72102  1.000 30.95382 ? 594 HOH   A O   1 
HETATM 2500 O O   . HOH   C 3 .   ? -22.55302 1.37959   -13.81870 1.000 37.88663 ? 595 HOH   A O   1 
HETATM 2501 O O   . HOH   C 3 .   ? -13.62476 1.41638   12.71245  1.000 38.87944 ? 596 HOH   A O   1 
HETATM 2502 O O   . HOH   C 3 .   ? -25.79986 -0.98721  -6.49083  1.000 25.20841 ? 597 HOH   A O   1 
HETATM 2503 O O   . HOH   C 3 .   ? -5.11894  -43.67441 21.54158  1.000 44.07067 ? 598 HOH   A O   1 
HETATM 2504 O O   . HOH   C 3 .   ? -29.67690 -24.46104 7.07925   1.000 28.69614 ? 599 HOH   A O   1 
HETATM 2505 O O   . HOH   C 3 .   ? 3.79950   -4.89985  -11.83463 1.000 22.31388 ? 600 HOH   A O   1 
HETATM 2506 O O   . HOH   C 3 .   ? -0.03675  -0.86589  -24.87348 1.000 28.69212 ? 601 HOH   A O   1 
HETATM 2507 O O   . HOH   C 3 .   ? -1.87374  -24.25068 -1.43860  1.000 23.06545 ? 602 HOH   A O   1 
HETATM 2508 O O   . HOH   C 3 .   ? -13.87905 -7.70666  -19.49074 1.000 24.55999 ? 603 HOH   A O   1 
HETATM 2509 O O   . HOH   C 3 .   ? -12.66525 -18.18773 18.86884  1.000 30.99969 ? 604 HOH   A O   1 
HETATM 2510 O O   . HOH   C 3 .   ? -24.47474 -41.97808 9.35122   1.000 39.85389 ? 605 HOH   A O   1 
HETATM 2511 O O   . HOH   C 3 .   ? -2.45892  -4.90303  2.38533   1.000 13.97210 ? 606 HOH   A O   1 
HETATM 2512 O O   . HOH   C 3 .   ? -31.35772 -27.99297 10.54772  1.000 40.53778 ? 607 HOH   A O   1 
HETATM 2513 O O   . HOH   C 3 .   ? -16.25974 -39.64042 3.70110   1.000 26.62609 ? 608 HOH   A O   1 
HETATM 2514 O O   . HOH   C 3 .   ? 3.79047   2.27557   -12.81959 1.000 20.09950 ? 609 HOH   A O   1 
HETATM 2515 O O   . HOH   C 3 .   ? -18.44624 -26.68795 1.70418   1.000 23.00806 ? 610 HOH   A O   1 
HETATM 2516 O O   . HOH   C 3 .   ? -1.36097  5.91002   -25.91954 1.000 30.67986 ? 611 HOH   A O   1 
HETATM 2517 O O   . HOH   C 3 .   ? -4.61337  -8.20696  -14.35957 1.000 14.78627 ? 612 HOH   A O   1 
HETATM 2518 O O   . HOH   C 3 .   ? -10.22421 -25.29954 -6.83440  1.000 20.17524 ? 613 HOH   A O   1 
HETATM 2519 O O   . HOH   C 3 .   ? 1.02578   -12.29021 -12.69594 1.000 14.88504 ? 614 HOH   A O   1 
HETATM 2520 O O   . HOH   C 3 .   ? -25.52981 -26.18019 5.78729   1.000 20.53606 ? 615 HOH   A O   1 
HETATM 2521 O O   . HOH   C 3 .   ? -31.22181 -23.57388 9.12864   1.000 29.36514 ? 616 HOH   A O   1 
HETATM 2522 O O   . HOH   C 3 .   ? -11.92706 -28.99242 -1.97582  1.000 25.03315 ? 617 HOH   A O   1 
HETATM 2523 O O   . HOH   C 3 .   ? -4.08531  -33.60543 7.00702   1.000 31.72460 ? 618 HOH   A O   1 
HETATM 2524 O O   . HOH   C 3 .   ? -22.27713 -16.18071 9.17825   1.000 14.83838 ? 619 HOH   A O   1 
HETATM 2525 O O   . HOH   C 3 .   ? -6.57018  -30.86359 21.93926  1.000 27.93591 ? 620 HOH   A O   1 
HETATM 2526 O O   . HOH   C 3 .   ? -3.15486  -23.78298 2.00370   1.000 24.29896 ? 621 HOH   A O   1 
HETATM 2527 O O   . HOH   C 3 .   ? -10.97693 -25.20376 23.31323  1.000 25.43584 ? 622 HOH   A O   1 
HETATM 2528 O O   . HOH   C 3 .   ? -18.85866 -34.45009 2.74632   1.000 24.00225 ? 623 HOH   A O   1 
HETATM 2529 O O   . HOH   C 3 .   ? -20.69702 2.80681   -11.75856 1.000 28.05162 ? 624 HOH   A O   1 
HETATM 2530 O O   . HOH   C 3 .   ? -5.04790  -0.74593  4.65613   1.000 21.73025 ? 625 HOH   A O   1 
HETATM 2531 O O   . HOH   C 3 .   ? -19.34549 -17.58404 5.45530   1.000 17.96013 ? 626 HOH   A O   1 
HETATM 2532 O O   . HOH   C 3 .   ? 1.10268   -11.47910 -8.07165  1.000 11.34625 ? 627 HOH   A O   1 
HETATM 2533 O O   . HOH   C 3 .   ? -19.44832 -4.73426  -21.60354 1.000 35.71569 ? 628 HOH   A O   1 
HETATM 2534 O O   . HOH   C 3 .   ? -2.28729  -14.87869 2.42459   1.000 12.54702 ? 629 HOH   A O   1 
HETATM 2535 O O   . HOH   C 3 .   ? -13.00163 -17.58335 12.78817  1.000 21.69415 ? 630 HOH   A O   1 
HETATM 2536 O O   . HOH   C 3 .   ? 5.50128   1.08052   -17.58248 1.000 23.80319 ? 631 HOH   A O   1 
HETATM 2537 O O   . HOH   C 3 .   ? -25.17419 -31.65343 24.89510  1.000 30.51055 ? 632 HOH   A O   1 
HETATM 2538 O O   . HOH   C 3 .   ? -23.95790 -16.36119 -0.34304  1.000 22.85184 ? 633 HOH   A O   1 
HETATM 2539 O O   . HOH   C 3 .   ? -32.71271 -18.18266 17.94563  1.000 25.36290 ? 634 HOH   A O   1 
HETATM 2540 O O   . HOH   C 3 .   ? 2.25720   -7.71487  -26.42795 1.000 40.40817 ? 635 HOH   A O   1 
HETATM 2541 O O   . HOH   C 3 .   ? -13.15780 -29.13267 24.52629  1.000 32.03201 ? 636 HOH   A O   1 
HETATM 2542 O O   . HOH   C 3 .   ? -0.00000  -16.23630 0.00000   0.50  12.03106 ? 637 HOH   A O   1 
HETATM 2543 O O   . HOH   C 3 .   ? -10.39662 -21.12321 -18.01668 1.000 31.10100 ? 638 HOH   A O   1 
HETATM 2544 O O   . HOH   C 3 .   ? -12.74707 -14.37025 7.30918   1.000 21.88166 ? 639 HOH   A O   1 
HETATM 2545 O O   . HOH   C 3 .   ? -17.43524 3.76677   6.80070   1.000 27.20458 ? 640 HOH   A O   1 
HETATM 2546 O O   . HOH   C 3 .   ? -8.36172  -27.13254 9.62814   1.000 14.58233 ? 641 HOH   A O   1 
HETATM 2547 O O   . HOH   C 3 .   ? 4.44709   -2.60943  -9.55703  1.000 27.96763 ? 642 HOH   A O   1 
HETATM 2548 O O   . HOH   C 3 .   ? -2.94589  -13.18295 6.43579   1.000 16.33899 ? 643 HOH   A O   1 
HETATM 2549 O O   . HOH   C 3 .   ? -17.52897 -5.85693  -20.01739 1.000 28.86256 ? 644 HOH   A O   1 
HETATM 2550 O O   . HOH   C 3 .   ? -11.62554 -31.28124 23.60893  1.000 28.68520 ? 645 HOH   A O   1 
HETATM 2551 O O   . HOH   C 3 .   ? -9.84891  7.49266   3.22895   1.000 35.12966 ? 646 HOH   A O   1 
HETATM 2552 O O   . HOH   C 3 .   ? -19.27586 -19.41747 24.74041  1.000 31.55356 ? 647 HOH   A O   1 
HETATM 2553 O O   . HOH   C 3 .   ? -10.71654 -26.67680 -9.00749  1.000 23.20032 ? 648 HOH   A O   1 
HETATM 2554 O O   . HOH   C 3 .   ? -1.45789  -37.58972 13.81974  1.000 34.68887 ? 649 HOH   A O   1 
HETATM 2555 O O   . HOH   C 3 .   ? 0.74300   8.96617   -14.62136 1.000 27.17388 ? 650 HOH   A O   1 
HETATM 2556 O O   . HOH   C 3 .   ? -33.01966 -28.88048 13.71619  1.000 32.83369 ? 651 HOH   A O   1 
HETATM 2557 O O   . HOH   C 3 .   ? -11.29209 -9.09658  4.50087   1.000 14.40947 ? 652 HOH   A O   1 
HETATM 2558 O O   . HOH   C 3 .   ? 3.56401   -7.53158  -24.66425 1.000 36.98975 ? 653 HOH   A O   1 
HETATM 2559 O O   . HOH   C 3 .   ? -6.38730  -21.55198 10.74386  1.000 34.32366 ? 654 HOH   A O   1 
HETATM 2560 O O   . HOH   C 3 .   ? -22.00638 -16.85841 6.29414   1.000 13.27280 ? 655 HOH   A O   1 
HETATM 2561 O O   . HOH   C 3 .   ? -7.32511  5.01166   -2.40214  1.000 22.74321 ? 656 HOH   A O   1 
HETATM 2562 O O   . HOH   C 3 .   ? 1.107     -23.272   -19.431   1.000 35.99769 ? 657 HOH   A O   1 
HETATM 2563 O O   . HOH   C 3 .   ? -4.73848  -24.19163 4.13405   1.000 25.53659 ? 658 HOH   A O   1 
HETATM 2564 O O   . HOH   C 3 .   ? -5.02708  -21.34383 13.25858  1.000 28.85563 ? 659 HOH   A O   1 
HETATM 2565 O O   . HOH   C 3 .   ? 1.36753   -20.71282 -15.56532 1.000 28.28064 ? 660 HOH   A O   1 
HETATM 2566 O O   . HOH   C 3 .   ? -26.57458 -23.54722 5.52456   1.000 29.97224 ? 661 HOH   A O   1 
HETATM 2567 O O   . HOH   C 3 .   ? 0.05703   -23.10587 -10.62493 1.000 30.65785 ? 662 HOH   A O   1 
HETATM 2568 O O   . HOH   C 3 .   ? -4.17364  -20.71077 6.79037   1.000 22.61187 ? 663 HOH   A O   1 
HETATM 2569 O O   . HOH   C 3 .   ? -2.16597  0.42984   0.92873   1.000 42.54978 ? 664 HOH   A O   1 
HETATM 2570 O O   . HOH   C 3 .   ? -7.74468  -19.46830 8.05559   1.000 23.22051 ? 665 HOH   A O   1 
HETATM 2571 O O   . HOH   C 3 .   ? -27.55850 -28.64545 0.32464   1.000 30.08368 ? 666 HOH   A O   1 
HETATM 2572 O O   . HOH   C 3 .   ? -31.39967 -40.36060 13.08666  1.000 37.94974 ? 667 HOH   A O   1 
HETATM 2573 O O   . HOH   C 3 .   ? -1.29925  -24.74770 17.29380  1.000 27.50220 ? 668 HOH   A O   1 
HETATM 2574 O O   . HOH   C 3 .   ? 4.83500   -8.53918  -8.30646  1.000 26.21118 ? 669 HOH   A O   1 
HETATM 2575 O O   . HOH   C 3 .   ? -4.45560  -27.94652 -0.75818  1.000 27.38457 ? 670 HOH   A O   1 
HETATM 2576 O O   . HOH   C 3 .   ? -25.79985 -31.08422 0.00000   0.50  18.88024 ? 671 HOH   A O   1 
HETATM 2577 O O   . HOH   C 3 .   ? -26.310   -12.020   13.400    1.000 41.07338 ? 672 HOH   A O   1 
HETATM 2578 O O   . HOH   C 3 .   ? -0.52357  10.42722  -19.20359 1.000 33.43140 ? 673 HOH   A O   1 
HETATM 2579 O O   . HOH   C 3 .   ? -7.71491  -28.30557 24.46908  1.000 34.91731 ? 674 HOH   A O   1 
HETATM 2580 O O   . HOH   C 3 .   ? -8.05410  -32.13674 -5.29001  1.000 31.78363 ? 675 HOH   A O   1 
HETATM 2581 O O   . HOH   C 3 .   ? -22.16922 -5.78311  -21.27746 1.000 39.75396 ? 676 HOH   A O   1 
HETATM 2582 O O   . HOH   C 3 .   ? -3.64027  -34.40382 9.49732   1.000 32.01095 ? 677 HOH   A O   1 
HETATM 2583 O O   . HOH   C 3 .   ? 5.00911   -8.38812  -17.36177 1.000 27.99850 ? 678 HOH   A O   1 
HETATM 2584 O O   . HOH   C 3 .   ? 0.29066   -17.05764 -2.67607  1.000 11.48648 ? 679 HOH   A O   1 
HETATM 2585 O O   . HOH   C 3 .   ? -1.39270  -29.75180 -7.34095  1.000 31.73978 ? 680 HOH   A O   1 
HETATM 2586 O O   . HOH   C 3 .   ? -12.85317 15.85484  -5.04979  1.000 28.73838 ? 681 HOH   A O   1 
HETATM 2587 O O   . HOH   C 3 .   ? -9.98202  4.60852   5.66804   1.000 25.72660 ? 682 HOH   A O   1 
HETATM 2588 O O   . HOH   C 3 .   ? -0.68679  -24.45477 -13.24914 1.000 30.34110 ? 683 HOH   A O   1 
HETATM 2589 O O   . HOH   C 3 .   ? -27.80685 -20.38127 2.03076   1.000 21.89343 ? 684 HOH   A O   1 
HETATM 2590 O O   . HOH   C 3 .   ? -33.48144 -24.02983 16.39287  1.000 32.46732 ? 685 HOH   A O   1 
HETATM 2591 O O   . HOH   C 3 .   ? -15.16516 -5.97343  -22.88136 1.000 35.25289 ? 686 HOH   A O   1 
HETATM 2592 O O   . HOH   C 3 .   ? -11.82766 6.52290   4.56884   1.000 28.78264 ? 687 HOH   A O   1 
HETATM 2593 O O   . HOH   C 3 .   ? -5.38428  -13.21351 8.16249   1.000 22.54815 ? 688 HOH   A O   1 
HETATM 2594 O O   . HOH   C 3 .   ? 1.36399   -13.29934 -9.99239  1.000 20.80644 ? 689 HOH   A O   1 
HETATM 2595 O O   . HOH   C 3 .   ? 0.21733   11.11153  -16.14160 1.000 31.79511 ? 690 HOH   A O   1 
HETATM 2596 O O   . HOH   C 3 .   ? -7.16486  -28.22290 -11.77901 1.000 31.04762 ? 691 HOH   A O   1 
HETATM 2597 O O   . HOH   C 3 .   ? -23.41987 1.25902   -9.75603  1.000 31.48305 ? 692 HOH   A O   1 
HETATM 2598 O O   . HOH   C 3 .   ? -3.38280  11.89871  -21.31057 1.000 29.58806 ? 693 HOH   A O   1 
HETATM 2599 O O   . HOH   C 3 .   ? -20.37911 -34.91270 24.24498  1.000 37.65516 ? 694 HOH   A O   1 
HETATM 2600 O O   . HOH   C 3 .   ? -24.38157 3.01086   -1.78121  1.000 31.85582 ? 695 HOH   A O   1 
HETATM 2601 O O   . HOH   C 3 .   ? 0.195     3.100     -28.168   1.000 27.99132 ? 696 HOH   A O   1 
HETATM 2602 O O   . HOH   C 3 .   ? 3.197     -6.933    -0.748    1.000 22.38065 ? 697 HOH   A O   1 
HETATM 2603 O O   . HOH   C 3 .   ? -0.56485  -27.74082 16.92309  1.000 31.57995 ? 698 HOH   A O   1 
HETATM 2604 O O   . HOH   C 3 .   ? -21.09051 -33.89670 25.64897  1.000 38.57821 ? 699 HOH   A O   1 
HETATM 2605 O O   . HOH   C 3 .   ? -11.35274 -35.63265 25.32533  1.000 41.12854 ? 700 HOH   A O   1 
HETATM 2606 O O   . HOH   C 3 .   ? 3.64607   -10.84198 -17.27533 1.000 34.27323 ? 701 HOH   A O   1 
HETATM 2607 O O   . HOH   C 3 .   ? 5.85730   -5.65416  -25.76246 1.000 37.56415 ? 702 HOH   A O   1 
HETATM 2608 O O   . HOH   C 3 .   ? -13.88036 -29.77937 -0.36281  1.000 33.67436 ? 703 HOH   A O   1 
HETATM 2609 O O   . HOH   C 3 .   ? -31.22861 -34.62508 14.80536  1.000 26.85849 ? 704 HOH   A O   1 
HETATM 2610 O O   . HOH   C 3 .   ? -14.98863 -11.16186 9.14311   1.000 30.75366 ? 705 HOH   A O   1 
HETATM 2611 O O   . HOH   C 3 .   ? -19.20864 -15.95833 -19.62277 1.000 32.74069 ? 706 HOH   A O   1 
HETATM 2612 O O   . HOH   C 3 .   ? -11.68061 -8.54598  -18.96091 1.000 24.48048 ? 707 HOH   A O   1 
HETATM 2613 O O   . HOH   C 3 .   ? -11.93171 -3.80758  10.88426  1.000 35.75070 ? 708 HOH   A O   1 
HETATM 2614 O O   . HOH   C 3 .   ? -22.179   -2.033    6.356     1.000 30.86001 ? 709 HOH   A O   1 
HETATM 2615 O O   . HOH   C 3 .   ? -1.23788  -34.96678 14.15260  1.000 47.83116 ? 710 HOH   A O   1 
HETATM 2616 O O   . HOH   C 3 .   ? 1.19846   -2.12795  -27.24581 1.000 33.96059 ? 711 HOH   A O   1 
HETATM 2617 O O   . HOH   C 3 .   ? -2.34730  -26.44532 -0.37032  1.000 44.92805 ? 712 HOH   A O   1 
HETATM 2618 O O   . HOH   C 3 .   ? -2.65706  -38.82392 22.00381  1.000 39.73747 ? 713 HOH   A O   1 
HETATM 2619 O O   . HOH   C 3 .   ? -15.06941 -9.50506  10.00065  1.000 31.26090 ? 714 HOH   A O   1 
HETATM 2620 O O   . HOH   C 3 .   ? -0.81879  8.75463   -10.56271 1.000 40.27915 ? 715 HOH   A O   1 
HETATM 2621 O O   . HOH   C 3 .   ? -32.32493 -27.19802 8.05991   1.000 39.10844 ? 716 HOH   A O   1 
HETATM 2622 O O   . HOH   C 3 .   ? 1.30082   9.30255   -12.77938 1.000 42.41496 ? 717 HOH   A O   1 
HETATM 2623 O O   . HOH   C 3 .   ? -22.50066 4.08541   0.26511   1.000 24.72428 ? 718 HOH   A O   1 
HETATM 2624 O O   . HOH   C 3 .   ? -6.68752  -17.67094 9.75777   1.000 28.28185 ? 719 HOH   A O   1 
HETATM 2625 O O   . HOH   C 3 .   ? -2.55836  5.94430   -2.67716  1.000 44.19235 ? 720 HOH   A O   1 
HETATM 2626 O O   . HOH   C 3 .   ? -2.75332  -17.04286 9.51389   1.000 23.76780 ? 721 HOH   A O   1 
HETATM 2627 O O   . HOH   C 3 .   ? -13.07066 -28.26883 -8.75026  1.000 37.82880 ? 722 HOH   A O   1 
HETATM 2628 O O   . HOH   C 3 .   ? -1.076    -23.433   14.896    1.000 28.39517 ? 723 HOH   A O   1 
HETATM 2629 O O   . HOH   C 3 .   ? -19.02440 -29.06220 0.32839   1.000 34.34110 ? 724 HOH   A O   1 
HETATM 2630 O O   . HOH   C 3 .   ? 3.52145   -18.82270 -10.64596 1.000 27.17879 ? 725 HOH   A O   1 
HETATM 2631 O O   . HOH   C 3 .   ? -14.33168 -23.35995 -18.75226 1.000 37.33471 ? 726 HOH   A O   1 
HETATM 2632 O O   . HOH   C 3 .   ? 4.18311   4.00389   -17.57809 1.000 24.53434 ? 727 HOH   A O   1 
HETATM 2633 O O   . HOH   C 3 .   ? -7.64464  -20.78816 12.23479  1.000 26.14946 ? 728 HOH   A O   1 
HETATM 2634 O O   . HOH   C 3 .   ? -18.79021 -38.86663 3.67583   1.000 37.93802 ? 729 HOH   A O   1 
HETATM 2635 O O   . HOH   C 3 .   ? -17.040   -20.078   -19.448   1.000 36.76710 ? 730 HOH   A O   1 
HETATM 2636 O O   . HOH   C 3 .   ? -33.51253 -30.30996 5.72993   1.000 36.70064 ? 731 HOH   A O   1 
HETATM 2637 O O   . HOH   C 3 .   ? 6.991     -17.619   -19.854   1.000 38.26910 ? 732 HOH   A O   1 
HETATM 2638 O O   . HOH   C 3 .   ? -12.79609 -9.03313  8.98540   1.000 43.55054 ? 733 HOH   A O   1 
HETATM 2639 O O   . HOH   C 3 .   ? 3.12017   1.49567   -2.23436  1.000 43.51380 ? 734 HOH   A O   1 
HETATM 2640 O O   . HOH   C 3 .   ? -18.43456 -8.51982  -21.40689 1.000 46.69628 ? 735 HOH   A O   1 
HETATM 2641 O O   . HOH   C 3 .   ? -8.77069  -11.01464 7.76709   1.000 27.65876 ? 736 HOH   A O   1 
HETATM 2642 O O   . HOH   C 3 .   ? -10.77248 -9.18059  7.19509   1.000 24.14921 ? 737 HOH   A O   1 
HETATM 2643 O O   . HOH   C 3 .   ? -8.02452  -27.80768 -14.75652 1.000 33.52840 ? 738 HOH   A O   1 
HETATM 2644 O O   . HOH   C 3 .   ? -15.78677 14.25714  -1.26816  1.000 35.93789 ? 739 HOH   A O   1 
HETATM 2645 O O   . HOH   C 3 .   ? -1.80222  -20.41937 22.31925  1.000 39.05796 ? 740 HOH   A O   1 
HETATM 2646 O O   . HOH   C 3 .   ? -4.529    -20.434   9.012     1.000 30.65427 ? 741 HOH   A O   1 
HETATM 2647 O O   . HOH   C 3 .   ? -28.81901 -26.86467 22.39610  1.000 38.83081 ? 742 HOH   A O   1 
HETATM 2648 O O   . HOH   C 3 .   ? -5.19496  6.59637   -1.65111  1.000 39.09537 ? 743 HOH   A O   1 
HETATM 2649 O O   . HOH   C 3 .   ? -15.00931 -17.27412 18.76675  1.000 31.78485 ? 744 HOH   A O   1 
HETATM 2650 O O   . HOH   C 3 .   ? -23.290   -0.818    -20.861   1.000 46.52069 ? 745 HOH   A O   1 
HETATM 2651 O O   . HOH   C 3 .   ? -22.62945 -40.58854 12.77302  1.000 36.04978 ? 746 HOH   A O   1 
HETATM 2652 O O   . HOH   C 3 .   ? -2.24965  -26.09808 2.33102   1.000 32.56634 ? 747 HOH   A O   1 
HETATM 2653 O O   . HOH   C 3 .   ? -19.59526 4.58470   4.77044   1.000 30.59591 ? 748 HOH   A O   1 
HETATM 2654 O O   . HOH   C 3 .   ? -1.93982  6.70306   -7.40848  1.000 29.60439 ? 749 HOH   A O   1 
HETATM 2655 O O   . HOH   C 3 .   ? -20.09368 -36.93242 3.26193   1.000 36.81113 ? 750 HOH   A O   1 
HETATM 2656 O O   . HOH   C 3 .   ? -5.02465  0.75828   6.48424   1.000 40.52734 ? 751 HOH   A O   1 
HETATM 2657 O O   . HOH   C 3 .   ? -18.29797 14.60113  -5.38057  1.000 34.93269 ? 752 HOH   A O   1 
HETATM 2658 O O   . HOH   C 3 .   ? -2.30005  8.49311   -5.77870  1.000 38.41312 ? 753 HOH   A O   1 
HETATM 2659 O O   . HOH   C 3 .   ? -0.00000  -23.78863 0.00000   0.50  30.39420 ? 754 HOH   A O   1 
HETATM 2660 O O   . HOH   C 3 .   ? -3.80634  -14.34311 9.84413   1.000 24.70946 ? 755 HOH   A O   1 
HETATM 2661 O O   . HOH   C 3 .   ? -5.020    -16.393   10.930    1.000 32.00794 ? 756 HOH   A O   1 
HETATM 2662 O O   . HOH   C 3 .   ? -3.230    -22.781   5.728     1.000 20.59956 ? 757 HOH   A O   1 
HETATM 2663 O O   . HOH   C 3 .   ? -11.38452 -33.20926 25.34263  1.000 31.69712 ? 758 HOH   A O   1 
HETATM 2664 O O   . HOH   C 3 .   ? -3.99105  2.06788   1.44616   1.000 37.55608 ? 759 HOH   A O   1 
HETATM 2665 O O   . HOH   C 3 .   ? -25.79985 -20.92883 0.00000   0.50  41.43351 ? 760 HOH   A O   1 
HETATM 2666 O O   . HOH   C 3 .   ? -1.08439  -33.90091 10.78747  1.000 40.79378 ? 761 HOH   A O   1 
HETATM 2667 O O   . HOH   C 3 .   ? -12.00604 -16.24416 15.41213  1.000 34.47793 ? 762 HOH   A O   1 
HETATM 2668 O O   . HOH   C 3 .   ? -13.78159 -13.48904 10.32523  1.000 31.31974 ? 763 HOH   A O   1 
HETATM 2669 O O   . HOH   C 3 .   ? -2.048    -24.679   6.662     1.000 33.57422 ? 764 HOH   A O   1 
HETATM 2670 O O   . HOH   C 3 .   ? 5.34872   3.64428   -10.93906 1.000 44.13728 ? 765 HOH   A O   1 
HETATM 2671 O O   . HOH   C 3 .   ? -15.31445 -37.38739 2.85852   1.000 28.41277 ? 766 HOH   A O   1 
HETATM 2672 O O   . HOH   C 3 .   ? -21.46528 -15.68436 -20.51204 1.000 37.76978 ? 767 HOH   A O   1 
HETATM 2673 O O   . HOH   C 3 .   ? -8.72222  -30.91552 23.59322  1.000 30.93357 ? 768 HOH   A O   1 
HETATM 2674 O O   . HOH   C 3 .   ? -7.73761  -32.72750 -7.81986  1.000 40.57579 ? 769 HOH   A O   1 
HETATM 2675 O O   . HOH   C 3 .   ? -0.554    -33.492   -8.253    1.000 36.10781 ? 770 HOH   A O   1 
HETATM 2676 O O   . HOH   C 3 .   ? -6.96448  -28.88660 -17.32718 1.000 37.08965 ? 771 HOH   A O   1 
HETATM 2677 O O   . HOH   C 3 .   ? -16.84154 -16.26820 20.61853  1.000 34.07995 ? 772 HOH   A O   1 
# 
