data_9BOD
# 
_entry.id   9BOD 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BOD         pdb_00009bod 10.2210/pdb9bod/pdb 
WWPDB D_1000283417 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-12 ? 
2 'Structure model' 1 1 2025-03-12 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
_pdbx_audit_revision_category.ordinal             1 
_pdbx_audit_revision_category.revision_ordinal    2 
_pdbx_audit_revision_category.data_content_type   'Structure model' 
_pdbx_audit_revision_category.category            citation 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
5 2 'Structure model' '_citation.title'                   
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BOD 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-03 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              karen.anderson@yale.edu 
_pdbx_contact_author.name_first         Karen 
_pdbx_contact_author.name_last          Anderson 
_pdbx_contact_author.name_mi            S 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-3433-0780 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Papini, C.'     1 0000-0002-6098-4959 
'Kenneson, J.'   2 ?                   
'Anderson, K.S.' 3 0000-0003-3433-0780 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Acs Bio Med Chem Au' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2694-2437 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            5 
_citation.language                  ? 
_citation.page_first                215 
_citation.page_last                 226 
_citation.title                     
'Exploring Possible Drug-Resistant Variants of SARS-CoV-2 Main Protease (M pro ) with Noncovalent Preclinical Candidate, Mpro61.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acsbiomedchemau.4c00109 
_citation.pdbx_database_id_PubMed   39990941 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Kenneson, J.R.'  1 ? 
primary 'Papini, C.'      2 ? 
primary 'Tang, S.'        3 ? 
primary 'Huynh, K.'       4 ? 
primary 'Zhang, C.H.'     5 ? 
primary 'Jorgensen, W.L.' 6 ? 
primary 'Anderson, K.S.'  7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '3C-like proteinase nsp5'                                                                              33829.578 
1   3.4.22.69 ? ? ? 
2 non-polymer syn 'N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide' 405.488   
1   ?         ? ? ? 
3 water       nat water                                                                                                  18.015    
130 ?         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMFNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMVLPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMFNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMVLPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide' UED 
3 water                                                                                                  HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   GLY n 
1 3   PHE n 
1 4   ARG n 
1 5   LYS n 
1 6   MET n 
1 7   ALA n 
1 8   PHE n 
1 9   PRO n 
1 10  SER n 
1 11  GLY n 
1 12  LYS n 
1 13  VAL n 
1 14  GLU n 
1 15  GLY n 
1 16  CYS n 
1 17  MET n 
1 18  VAL n 
1 19  GLN n 
1 20  VAL n 
1 21  THR n 
1 22  CYS n 
1 23  GLY n 
1 24  THR n 
1 25  THR n 
1 26  THR n 
1 27  LEU n 
1 28  ASN n 
1 29  GLY n 
1 30  LEU n 
1 31  TRP n 
1 32  LEU n 
1 33  ASP n 
1 34  ASP n 
1 35  VAL n 
1 36  VAL n 
1 37  TYR n 
1 38  CYS n 
1 39  PRO n 
1 40  ARG n 
1 41  HIS n 
1 42  VAL n 
1 43  ILE n 
1 44  CYS n 
1 45  THR n 
1 46  SER n 
1 47  GLU n 
1 48  ASP n 
1 49  MET n 
1 50  PHE n 
1 51  ASN n 
1 52  PRO n 
1 53  ASN n 
1 54  TYR n 
1 55  GLU n 
1 56  ASP n 
1 57  LEU n 
1 58  LEU n 
1 59  ILE n 
1 60  ARG n 
1 61  LYS n 
1 62  SER n 
1 63  ASN n 
1 64  HIS n 
1 65  ASN n 
1 66  PHE n 
1 67  LEU n 
1 68  VAL n 
1 69  GLN n 
1 70  ALA n 
1 71  GLY n 
1 72  ASN n 
1 73  VAL n 
1 74  GLN n 
1 75  LEU n 
1 76  ARG n 
1 77  VAL n 
1 78  ILE n 
1 79  GLY n 
1 80  HIS n 
1 81  SER n 
1 82  MET n 
1 83  GLN n 
1 84  ASN n 
1 85  CYS n 
1 86  VAL n 
1 87  LEU n 
1 88  LYS n 
1 89  LEU n 
1 90  LYS n 
1 91  VAL n 
1 92  ASP n 
1 93  THR n 
1 94  ALA n 
1 95  ASN n 
1 96  PRO n 
1 97  LYS n 
1 98  THR n 
1 99  PRO n 
1 100 LYS n 
1 101 TYR n 
1 102 LYS n 
1 103 PHE n 
1 104 VAL n 
1 105 ARG n 
1 106 ILE n 
1 107 GLN n 
1 108 PRO n 
1 109 GLY n 
1 110 GLN n 
1 111 THR n 
1 112 PHE n 
1 113 SER n 
1 114 VAL n 
1 115 LEU n 
1 116 ALA n 
1 117 CYS n 
1 118 TYR n 
1 119 ASN n 
1 120 GLY n 
1 121 SER n 
1 122 PRO n 
1 123 SER n 
1 124 GLY n 
1 125 VAL n 
1 126 TYR n 
1 127 GLN n 
1 128 CYS n 
1 129 ALA n 
1 130 MET n 
1 131 ARG n 
1 132 PRO n 
1 133 ASN n 
1 134 PHE n 
1 135 THR n 
1 136 ILE n 
1 137 LYS n 
1 138 GLY n 
1 139 SER n 
1 140 PHE n 
1 141 LEU n 
1 142 ASN n 
1 143 GLY n 
1 144 SER n 
1 145 CYS n 
1 146 GLY n 
1 147 SER n 
1 148 VAL n 
1 149 GLY n 
1 150 PHE n 
1 151 ASN n 
1 152 ILE n 
1 153 ASP n 
1 154 TYR n 
1 155 ASP n 
1 156 CYS n 
1 157 VAL n 
1 158 SER n 
1 159 PHE n 
1 160 CYS n 
1 161 TYR n 
1 162 MET n 
1 163 HIS n 
1 164 HIS n 
1 165 MET n 
1 166 VAL n 
1 167 LEU n 
1 168 PRO n 
1 169 THR n 
1 170 GLY n 
1 171 VAL n 
1 172 HIS n 
1 173 ALA n 
1 174 GLY n 
1 175 THR n 
1 176 ASP n 
1 177 LEU n 
1 178 GLU n 
1 179 GLY n 
1 180 ASN n 
1 181 PHE n 
1 182 TYR n 
1 183 GLY n 
1 184 PRO n 
1 185 PHE n 
1 186 VAL n 
1 187 ASP n 
1 188 ARG n 
1 189 GLN n 
1 190 THR n 
1 191 ALA n 
1 192 GLN n 
1 193 ALA n 
1 194 ALA n 
1 195 GLY n 
1 196 THR n 
1 197 ASP n 
1 198 THR n 
1 199 THR n 
1 200 ILE n 
1 201 THR n 
1 202 VAL n 
1 203 ASN n 
1 204 VAL n 
1 205 LEU n 
1 206 ALA n 
1 207 TRP n 
1 208 LEU n 
1 209 TYR n 
1 210 ALA n 
1 211 ALA n 
1 212 VAL n 
1 213 ILE n 
1 214 ASN n 
1 215 GLY n 
1 216 ASP n 
1 217 ARG n 
1 218 TRP n 
1 219 PHE n 
1 220 LEU n 
1 221 ASN n 
1 222 ARG n 
1 223 PHE n 
1 224 THR n 
1 225 THR n 
1 226 THR n 
1 227 LEU n 
1 228 ASN n 
1 229 ASP n 
1 230 PHE n 
1 231 ASN n 
1 232 LEU n 
1 233 VAL n 
1 234 ALA n 
1 235 MET n 
1 236 LYS n 
1 237 TYR n 
1 238 ASN n 
1 239 TYR n 
1 240 GLU n 
1 241 PRO n 
1 242 LEU n 
1 243 THR n 
1 244 GLN n 
1 245 ASP n 
1 246 HIS n 
1 247 VAL n 
1 248 ASP n 
1 249 ILE n 
1 250 LEU n 
1 251 GLY n 
1 252 PRO n 
1 253 LEU n 
1 254 SER n 
1 255 ALA n 
1 256 GLN n 
1 257 THR n 
1 258 GLY n 
1 259 ILE n 
1 260 ALA n 
1 261 VAL n 
1 262 LEU n 
1 263 ASP n 
1 264 MET n 
1 265 CYS n 
1 266 ALA n 
1 267 SER n 
1 268 LEU n 
1 269 LYS n 
1 270 GLU n 
1 271 LEU n 
1 272 LEU n 
1 273 GLN n 
1 274 ASN n 
1 275 GLY n 
1 276 MET n 
1 277 ASN n 
1 278 GLY n 
1 279 ARG n 
1 280 THR n 
1 281 ILE n 
1 282 LEU n 
1 283 GLY n 
1 284 SER n 
1 285 ALA n 
1 286 LEU n 
1 287 LEU n 
1 288 GLU n 
1 289 ASP n 
1 290 GLU n 
1 291 PHE n 
1 292 THR n 
1 293 PRO n 
1 294 PHE n 
1 295 ASP n 
1 296 VAL n 
1 297 VAL n 
1 298 ARG n 
1 299 GLN n 
1 300 CYS n 
1 301 SER n 
1 302 GLY n 
1 303 VAL n 
1 304 THR n 
1 305 PHE n 
1 306 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   306 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'rep, 1a-1b' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                                                                                ? 
'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                                                                               ? 
'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                                                                             ? 
'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                                                                        ? 
'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE                                                                                               ? 
'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE                                                                                              ? 
'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                                                                        ? 
'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                                                                                ? 
'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                                                                                              ? 
'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                                                                                  ? 
'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                                                                             ? 
'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                                                                                ? 
'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                                                                                 ? 
'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                                                                                             ? 
'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE                                                                                          ? 
'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                                                                                                ? 
'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                                                                                 ? 
'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                                                                                              ? 
'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                                                                             ? 
'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                                                                               ? 
'C9 H11 N O3'    181.189 
UED non-polymer         . 'N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide' 
'GC373 bound form, GC376 bound form' 'C21 H31 N3 O5'  405.488 
VAL 'L-peptide linking' y VALINE                                                                                                 ? 
'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   1   1   SER SER A . n 
A 1 2   GLY 2   2   2   GLY GLY A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   ARG 4   4   4   ARG ARG A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   MET 6   6   6   MET MET A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   PRO 9   9   9   PRO PRO A . n 
A 1 10  SER 10  10  10  SER SER A . n 
A 1 11  GLY 11  11  11  GLY GLY A . n 
A 1 12  LYS 12  12  12  LYS LYS A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  GLY 15  15  15  GLY GLY A . n 
A 1 16  CYS 16  16  16  CYS CYS A . n 
A 1 17  MET 17  17  17  MET MET A . n 
A 1 18  VAL 18  18  18  VAL VAL A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  THR 21  21  21  THR THR A . n 
A 1 22  CYS 22  22  22  CYS CYS A . n 
A 1 23  GLY 23  23  23  GLY GLY A . n 
A 1 24  THR 24  24  24  THR THR A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  THR 26  26  26  THR THR A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  ASN 28  28  28  ASN ASN A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  TRP 31  31  31  TRP TRP A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  ASP 33  33  33  ASP ASP A . n 
A 1 34  ASP 34  34  34  ASP ASP A . n 
A 1 35  VAL 35  35  35  VAL VAL A . n 
A 1 36  VAL 36  36  36  VAL VAL A . n 
A 1 37  TYR 37  37  37  TYR TYR A . n 
A 1 38  CYS 38  38  38  CYS CYS A . n 
A 1 39  PRO 39  39  39  PRO PRO A . n 
A 1 40  ARG 40  40  40  ARG ARG A . n 
A 1 41  HIS 41  41  41  HIS HIS A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  ILE 43  43  43  ILE ILE A . n 
A 1 44  CYS 44  44  44  CYS CYS A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  SER 46  46  46  SER SER A . n 
A 1 47  GLU 47  47  47  GLU GLU A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  MET 49  49  49  MET MET A . n 
A 1 50  PHE 50  50  50  PHE PHE A . n 
A 1 51  ASN 51  51  51  ASN ASN A . n 
A 1 52  PRO 52  52  52  PRO PRO A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  TYR 54  54  54  TYR TYR A . n 
A 1 55  GLU 55  55  55  GLU GLU A . n 
A 1 56  ASP 56  56  56  ASP ASP A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  ILE 59  59  59  ILE ILE A . n 
A 1 60  ARG 60  60  60  ARG ARG A . n 
A 1 61  LYS 61  61  61  LYS LYS A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  ASN 63  63  63  ASN ASN A . n 
A 1 64  HIS 64  64  64  HIS HIS A . n 
A 1 65  ASN 65  65  65  ASN ASN A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  GLN 69  69  69  GLN GLN A . n 
A 1 70  ALA 70  70  70  ALA ALA A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  ASN 72  72  72  ASN ASN A . n 
A 1 73  VAL 73  73  73  VAL VAL A . n 
A 1 74  GLN 74  74  74  GLN GLN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  ARG 76  76  76  ARG ARG A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  GLY 79  79  79  GLY GLY A . n 
A 1 80  HIS 80  80  80  HIS HIS A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  MET 82  82  82  MET MET A . n 
A 1 83  GLN 83  83  83  GLN GLN A . n 
A 1 84  ASN 84  84  84  ASN ASN A . n 
A 1 85  CYS 85  85  85  CYS CYS A . n 
A 1 86  VAL 86  86  86  VAL VAL A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  LYS 88  88  88  LYS LYS A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  LYS 90  90  90  LYS LYS A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  ASP 92  92  92  ASP ASP A . n 
A 1 93  THR 93  93  93  THR THR A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  PRO 96  96  96  PRO PRO A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  PRO 99  99  99  PRO PRO A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 TYR 101 101 101 TYR TYR A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 PHE 103 103 103 PHE PHE A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 ARG 105 105 105 ARG ARG A . n 
A 1 106 ILE 106 106 106 ILE ILE A . n 
A 1 107 GLN 107 107 107 GLN GLN A . n 
A 1 108 PRO 108 108 108 PRO PRO A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 GLN 110 110 110 GLN GLN A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 PHE 112 112 112 PHE PHE A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 CYS 117 117 117 CYS CYS A . n 
A 1 118 TYR 118 118 118 TYR TYR A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 SER 123 123 123 SER SER A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 MET 130 130 130 MET MET A . n 
A 1 131 ARG 131 131 131 ARG ARG A . n 
A 1 132 PRO 132 132 132 PRO PRO A . n 
A 1 133 ASN 133 133 133 ASN ASN A . n 
A 1 134 PHE 134 134 134 PHE PHE A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 LYS 137 137 137 LYS LYS A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 PHE 140 140 140 PHE PHE A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 ASN 142 142 142 ASN ASN A . n 
A 1 143 GLY 143 143 143 GLY GLY A . n 
A 1 144 SER 144 144 144 SER SER A . n 
A 1 145 CYS 145 145 145 CYS CYS A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 GLY 149 149 149 GLY GLY A . n 
A 1 150 PHE 150 150 150 PHE PHE A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 ILE 152 152 152 ILE ILE A . n 
A 1 153 ASP 153 153 153 ASP ASP A . n 
A 1 154 TYR 154 154 154 TYR TYR A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 CYS 156 156 156 CYS CYS A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 SER 158 158 158 SER SER A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 CYS 160 160 160 CYS CYS A . n 
A 1 161 TYR 161 161 161 TYR TYR A . n 
A 1 162 MET 162 162 162 MET MET A . n 
A 1 163 HIS 163 163 163 HIS HIS A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 MET 165 165 165 MET MET A . n 
A 1 166 VAL 166 166 166 VAL VAL A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 PRO 168 168 168 PRO PRO A . n 
A 1 169 THR 169 169 169 THR THR A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 VAL 171 171 171 VAL VAL A . n 
A 1 172 HIS 172 172 172 HIS HIS A . n 
A 1 173 ALA 173 173 173 ALA ALA A . n 
A 1 174 GLY 174 174 174 GLY GLY A . n 
A 1 175 THR 175 175 175 THR THR A . n 
A 1 176 ASP 176 176 176 ASP ASP A . n 
A 1 177 LEU 177 177 177 LEU LEU A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 TYR 182 182 182 TYR TYR A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 VAL 186 186 186 VAL VAL A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 GLN 189 189 189 GLN GLN A . n 
A 1 190 THR 190 190 190 THR THR A . n 
A 1 191 ALA 191 191 191 ALA ALA A . n 
A 1 192 GLN 192 192 192 GLN GLN A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 THR 196 196 196 THR THR A . n 
A 1 197 ASP 197 197 197 ASP ASP A . n 
A 1 198 THR 198 198 198 THR THR A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 ILE 200 200 200 ILE ILE A . n 
A 1 201 THR 201 201 201 THR THR A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 ALA 206 206 206 ALA ALA A . n 
A 1 207 TRP 207 207 207 TRP TRP A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ALA 210 210 210 ALA ALA A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ASN 214 214 214 ASN ASN A . n 
A 1 215 GLY 215 215 215 GLY GLY A . n 
A 1 216 ASP 216 216 216 ASP ASP A . n 
A 1 217 ARG 217 217 217 ARG ARG A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 ASN 221 221 221 ASN ASN A . n 
A 1 222 ARG 222 222 222 ARG ARG A . n 
A 1 223 PHE 223 223 223 PHE PHE A . n 
A 1 224 THR 224 224 224 THR THR A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 THR 226 226 226 THR THR A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 ASN 228 228 228 ASN ASN A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 PHE 230 230 230 PHE PHE A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 VAL 233 233 233 VAL VAL A . n 
A 1 234 ALA 234 234 234 ALA ALA A . n 
A 1 235 MET 235 235 235 MET MET A . n 
A 1 236 LYS 236 236 236 LYS LYS A . n 
A 1 237 TYR 237 237 237 TYR TYR A . n 
A 1 238 ASN 238 238 238 ASN ASN A . n 
A 1 239 TYR 239 239 239 TYR TYR A . n 
A 1 240 GLU 240 240 240 GLU GLU A . n 
A 1 241 PRO 241 241 241 PRO PRO A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 THR 243 243 243 THR THR A . n 
A 1 244 GLN 244 244 244 GLN GLN A . n 
A 1 245 ASP 245 245 245 ASP ASP A . n 
A 1 246 HIS 246 246 246 HIS HIS A . n 
A 1 247 VAL 247 247 247 VAL VAL A . n 
A 1 248 ASP 248 248 248 ASP ASP A . n 
A 1 249 ILE 249 249 249 ILE ILE A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 PRO 252 252 252 PRO PRO A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 SER 254 254 254 SER SER A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 THR 257 257 257 THR THR A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 ILE 259 259 259 ILE ILE A . n 
A 1 260 ALA 260 260 260 ALA ALA A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 LEU 262 262 262 LEU LEU A . n 
A 1 263 ASP 263 263 263 ASP ASP A . n 
A 1 264 MET 264 264 264 MET MET A . n 
A 1 265 CYS 265 265 265 CYS CYS A . n 
A 1 266 ALA 266 266 266 ALA ALA A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 LYS 269 269 269 LYS LYS A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 LEU 271 271 271 LEU LEU A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 ASN 274 274 274 ASN ASN A . n 
A 1 275 GLY 275 275 275 GLY GLY A . n 
A 1 276 MET 276 276 276 MET MET A . n 
A 1 277 ASN 277 277 277 ASN ASN A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 ARG 279 279 279 ARG ARG A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 ILE 281 281 281 ILE ILE A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 GLY 283 283 283 GLY GLY A . n 
A 1 284 SER 284 284 284 SER SER A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 LEU 286 286 286 LEU LEU A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 ASP 289 289 289 ASP ASP A . n 
A 1 290 GLU 290 290 290 GLU GLU A . n 
A 1 291 PHE 291 291 291 PHE PHE A . n 
A 1 292 THR 292 292 292 THR THR A . n 
A 1 293 PRO 293 293 293 PRO PRO A . n 
A 1 294 PHE 294 294 294 PHE PHE A . n 
A 1 295 ASP 295 295 295 ASP ASP A . n 
A 1 296 VAL 296 296 296 VAL VAL A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 GLN 299 299 299 GLN GLN A . n 
A 1 300 CYS 300 300 300 CYS CYS A . n 
A 1 301 SER 301 301 301 SER SER A . n 
A 1 302 GLY 302 302 302 GLY GLY A . n 
A 1 303 VAL 303 303 303 VAL VAL A . n 
A 1 304 THR 304 304 304 THR THR A . n 
A 1 305 PHE 305 305 ?   ?   ?   A . n 
A 1 306 GLN 306 306 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        UED 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   UED 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 UED 1   401 999 UED GCA A . 
C 3 HOH 1   501 78  HOH HOH A . 
C 3 HOH 2   502 134 HOH HOH A . 
C 3 HOH 3   503 3   HOH HOH A . 
C 3 HOH 4   504 15  HOH HOH A . 
C 3 HOH 5   505 44  HOH HOH A . 
C 3 HOH 6   506 46  HOH HOH A . 
C 3 HOH 7   507 38  HOH HOH A . 
C 3 HOH 8   508 48  HOH HOH A . 
C 3 HOH 9   509 117 HOH HOH A . 
C 3 HOH 10  510 47  HOH HOH A . 
C 3 HOH 11  511 39  HOH HOH A . 
C 3 HOH 12  512 35  HOH HOH A . 
C 3 HOH 13  513 119 HOH HOH A . 
C 3 HOH 14  514 58  HOH HOH A . 
C 3 HOH 15  515 65  HOH HOH A . 
C 3 HOH 16  516 74  HOH HOH A . 
C 3 HOH 17  517 37  HOH HOH A . 
C 3 HOH 18  518 9   HOH HOH A . 
C 3 HOH 19  519 27  HOH HOH A . 
C 3 HOH 20  520 16  HOH HOH A . 
C 3 HOH 21  521 26  HOH HOH A . 
C 3 HOH 22  522 10  HOH HOH A . 
C 3 HOH 23  523 124 HOH HOH A . 
C 3 HOH 24  524 12  HOH HOH A . 
C 3 HOH 25  525 50  HOH HOH A . 
C 3 HOH 26  526 57  HOH HOH A . 
C 3 HOH 27  527 28  HOH HOH A . 
C 3 HOH 28  528 36  HOH HOH A . 
C 3 HOH 29  529 6   HOH HOH A . 
C 3 HOH 30  530 120 HOH HOH A . 
C 3 HOH 31  531 72  HOH HOH A . 
C 3 HOH 32  532 62  HOH HOH A . 
C 3 HOH 33  533 5   HOH HOH A . 
C 3 HOH 34  534 1   HOH HOH A . 
C 3 HOH 35  535 66  HOH HOH A . 
C 3 HOH 36  536 60  HOH HOH A . 
C 3 HOH 37  537 51  HOH HOH A . 
C 3 HOH 38  538 94  HOH HOH A . 
C 3 HOH 39  539 17  HOH HOH A . 
C 3 HOH 40  540 59  HOH HOH A . 
C 3 HOH 41  541 84  HOH HOH A . 
C 3 HOH 42  542 23  HOH HOH A . 
C 3 HOH 43  543 73  HOH HOH A . 
C 3 HOH 44  544 107 HOH HOH A . 
C 3 HOH 45  545 7   HOH HOH A . 
C 3 HOH 46  546 71  HOH HOH A . 
C 3 HOH 47  547 125 HOH HOH A . 
C 3 HOH 48  548 2   HOH HOH A . 
C 3 HOH 49  549 105 HOH HOH A . 
C 3 HOH 50  550 33  HOH HOH A . 
C 3 HOH 51  551 8   HOH HOH A . 
C 3 HOH 52  552 4   HOH HOH A . 
C 3 HOH 53  553 32  HOH HOH A . 
C 3 HOH 54  554 54  HOH HOH A . 
C 3 HOH 55  555 126 HOH HOH A . 
C 3 HOH 56  556 18  HOH HOH A . 
C 3 HOH 57  557 61  HOH HOH A . 
C 3 HOH 58  558 113 HOH HOH A . 
C 3 HOH 59  559 22  HOH HOH A . 
C 3 HOH 60  560 79  HOH HOH A . 
C 3 HOH 61  561 30  HOH HOH A . 
C 3 HOH 62  562 75  HOH HOH A . 
C 3 HOH 63  563 56  HOH HOH A . 
C 3 HOH 64  564 121 HOH HOH A . 
C 3 HOH 65  565 31  HOH HOH A . 
C 3 HOH 66  566 136 HOH HOH A . 
C 3 HOH 67  567 82  HOH HOH A . 
C 3 HOH 68  568 49  HOH HOH A . 
C 3 HOH 69  569 81  HOH HOH A . 
C 3 HOH 70  570 111 HOH HOH A . 
C 3 HOH 71  571 132 HOH HOH A . 
C 3 HOH 72  572 128 HOH HOH A . 
C 3 HOH 73  573 52  HOH HOH A . 
C 3 HOH 74  574 63  HOH HOH A . 
C 3 HOH 75  575 41  HOH HOH A . 
C 3 HOH 76  576 137 HOH HOH A . 
C 3 HOH 77  577 76  HOH HOH A . 
C 3 HOH 78  578 130 HOH HOH A . 
C 3 HOH 79  579 103 HOH HOH A . 
C 3 HOH 80  580 34  HOH HOH A . 
C 3 HOH 81  581 21  HOH HOH A . 
C 3 HOH 82  582 24  HOH HOH A . 
C 3 HOH 83  583 85  HOH HOH A . 
C 3 HOH 84  584 92  HOH HOH A . 
C 3 HOH 85  585 118 HOH HOH A . 
C 3 HOH 86  586 40  HOH HOH A . 
C 3 HOH 87  587 93  HOH HOH A . 
C 3 HOH 88  588 69  HOH HOH A . 
C 3 HOH 89  589 133 HOH HOH A . 
C 3 HOH 90  590 129 HOH HOH A . 
C 3 HOH 91  591 104 HOH HOH A . 
C 3 HOH 92  592 25  HOH HOH A . 
C 3 HOH 93  593 87  HOH HOH A . 
C 3 HOH 94  594 102 HOH HOH A . 
C 3 HOH 95  595 43  HOH HOH A . 
C 3 HOH 96  596 77  HOH HOH A . 
C 3 HOH 97  597 116 HOH HOH A . 
C 3 HOH 98  598 19  HOH HOH A . 
C 3 HOH 99  599 14  HOH HOH A . 
C 3 HOH 100 600 88  HOH HOH A . 
C 3 HOH 101 601 83  HOH HOH A . 
C 3 HOH 102 602 131 HOH HOH A . 
C 3 HOH 103 603 97  HOH HOH A . 
C 3 HOH 104 604 112 HOH HOH A . 
C 3 HOH 105 605 13  HOH HOH A . 
C 3 HOH 106 606 89  HOH HOH A . 
C 3 HOH 107 607 135 HOH HOH A . 
C 3 HOH 108 608 29  HOH HOH A . 
C 3 HOH 109 609 91  HOH HOH A . 
C 3 HOH 110 610 96  HOH HOH A . 
C 3 HOH 111 611 55  HOH HOH A . 
C 3 HOH 112 612 109 HOH HOH A . 
C 3 HOH 113 613 106 HOH HOH A . 
C 3 HOH 114 614 123 HOH HOH A . 
C 3 HOH 115 615 110 HOH HOH A . 
C 3 HOH 116 616 64  HOH HOH A . 
C 3 HOH 117 617 114 HOH HOH A . 
C 3 HOH 118 618 80  HOH HOH A . 
C 3 HOH 119 619 115 HOH HOH A . 
C 3 HOH 120 620 127 HOH HOH A . 
C 3 HOH 121 621 95  HOH HOH A . 
C 3 HOH 122 622 68  HOH HOH A . 
C 3 HOH 123 623 100 HOH HOH A . 
C 3 HOH 124 624 67  HOH HOH A . 
C 3 HOH 125 625 98  HOH HOH A . 
C 3 HOH 126 626 99  HOH HOH A . 
C 3 HOH 127 627 90  HOH HOH A . 
C 3 HOH 128 628 86  HOH HOH A . 
C 3 HOH 129 629 20  HOH HOH A . 
C 3 HOH 130 630 45  HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A SER 46  ? OG  ? A SER 46  OG  
2  1 Y 1 A ASN 72  ? CG  ? A ASN 72  CG  
3  1 Y 1 A ASN 72  ? OD1 ? A ASN 72  OD1 
4  1 Y 1 A ASN 72  ? ND2 ? A ASN 72  ND2 
5  1 Y 1 A ASP 153 ? CG  ? A ASP 153 CG  
6  1 Y 1 A ASP 153 ? OD1 ? A ASP 153 OD1 
7  1 Y 1 A ASP 153 ? OD2 ? A ASP 153 OD2 
8  1 Y 1 A ARG 279 ? CG  ? A ARG 279 CG  
9  1 Y 1 A ARG 279 ? CD  ? A ARG 279 CD  
10 1 Y 1 A ARG 279 ? NE  ? A ARG 279 NE  
11 1 Y 1 A ARG 279 ? CZ  ? A ARG 279 CZ  
12 1 Y 1 A ARG 279 ? NH1 ? A ARG 279 NH1 
13 1 Y 1 A ARG 279 ? NH2 ? A ARG 279 NH2 
14 1 Y 1 A THR 304 ? OG1 ? A THR 304 OG1 
15 1 Y 1 A THR 304 ? CG2 ? A THR 304 CG2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   103.042 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BOD 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     112.481 
_cell.length_a_esd                 ? 
_cell.length_b                     52.614 
_cell.length_b_esd                 ? 
_cell.length_c                     45.942 
_cell.length_c_esd                 ? 
_cell.volume                       264874.835 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BOD 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y' 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BOD 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             1.96 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          37.16 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              8.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M BICINE, 15% w/v Polyethylene glycol 1,500' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            294 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-09-15 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.979330 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSLS-II BEAMLINE 17-ID-2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.979330 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   17-ID-2 
_diffrn_source.pdbx_synchrotron_site       NSLS-II 
# 
_reflns.B_iso_Wilson_estimate                          30.14 
_reflns.entry_id                                       9BOD 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.91 
_reflns.d_resolution_low                               54.79 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     20145 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           98.15 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.2 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          7.87 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.997 
_reflns.pdbx_CC_star                                   0.999 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.1434 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.91 
_reflns_shell.d_res_low                                     1.978 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.00 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2040 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               6.2 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.354 
_reflns_shell.pdbx_CC_star                                  0.723 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.76 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.699 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               34.11 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9BOD 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.91 
_refine.ls_d_res_low                             54.79 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     20145 
_refine.ls_number_reflns_R_free                  1017 
_refine.ls_number_reflns_R_work                  19128 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.15 
_refine.ls_percent_reflns_R_free                 5.05 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2020 
_refine.ls_R_factor_R_free                       0.2411 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1999 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 27.3550 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2699 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.91 
_refine_hist.d_res_low                        54.79 
_refine_hist.number_atoms_solvent             130 
_refine_hist.number_atoms_total               2492 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2333 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         29 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0028  ? 2426 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.6141  ? 3299 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0429  ? 372  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0037  ? 428  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 13.8561 ? 855  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.91 2.01  . . 139 2786 99.86  . . . . 0.2900 . . . . . . . . . . . 0.3172 
'X-RAY DIFFRACTION' 2.01 2.13  . . 141 2746 99.90  . . . . 0.2613 . . . . . . . . . . . 0.3211 
'X-RAY DIFFRACTION' 2.13 2.30  . . 137 2431 87.53  . . . . 0.2442 . . . . . . . . . . . 0.3065 
'X-RAY DIFFRACTION' 2.30 2.53  . . 142 2744 100.00 . . . . 0.2230 . . . . . . . . . . . 0.3039 
'X-RAY DIFFRACTION' 2.53 2.90  . . 145 2799 99.93  . . . . 0.2122 . . . . . . . . . . . 0.2567 
'X-RAY DIFFRACTION' 2.90 3.65  . . 150 2796 100.00 . . . . 0.1875 . . . . . . . . . . . 0.2355 
'X-RAY DIFFRACTION' 3.65 54.79 . . 163 2826 99.90  . . . . 0.1677 . . . . . . . . . . . 0.1935 
# 
_struct.entry_id                     9BOD 
_struct.title                        'Crystal Structure of E166V/L50F SARS-CoV-2 Main Protease in Complex with GC376' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BOD 
_struct_keywords.text            'Hydrolase, VIRAL PROTEIN' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1AB_SARS2 
_struct_ref.pdbx_db_accession          P0DTD1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_struct_ref.pdbx_align_begin           3264 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9BOD 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 306 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P0DTD1 
_struct_ref_seq.db_align_beg                  3264 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3569 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       306 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9BOD PHE A 50  ? UNP P0DTD1 LEU 3313 'engineered mutation' 50  1 
1 9BOD VAL A 166 ? UNP P0DTD1 GLU 3429 'engineered mutation' 166 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2960  ? 
1 MORE         -19   ? 
1 'SSA (A^2)'  24800 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z     1.0000000000  0.0000000000 0.0000000000 0.0000000000   0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000  
2 'crystal symmetry operation' 2_556 -x,y,-z+1 -1.0000000000 0.0000000000 0.0000000000 -10.3675126584 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 44.7569217583 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 10  ? GLY A 15  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 41  ? CYS A 44  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 GLU A 47  ? ASN A 51  ? GLU A 47  ASN A 51  5 ? 5  
HELX_P HELX_P4  AA4 ASN A 53  ? ARG A 60  ? ASN A 53  ARG A 60  1 ? 8  
HELX_P HELX_P5  AA5 LYS A 61  ? HIS A 64  ? LYS A 61  HIS A 64  5 ? 4  
HELX_P HELX_P6  AA6 ILE A 200 ? ASN A 214 ? ILE A 200 ASN A 214 1 ? 15 
HELX_P HELX_P7  AA7 THR A 226 ? MET A 235 ? THR A 226 MET A 235 1 ? 10 
HELX_P HELX_P8  AA8 LYS A 236 ? ASN A 238 ? LYS A 236 ASN A 238 5 ? 3  
HELX_P HELX_P9  AA9 THR A 243 ? LEU A 250 ? THR A 243 LEU A 250 1 ? 8  
HELX_P HELX_P10 AB1 LEU A 250 ? GLY A 258 ? LEU A 250 GLY A 258 1 ? 9  
HELX_P HELX_P11 AB2 ALA A 260 ? GLY A 275 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P12 AB3 THR A 292 ? SER A 301 ? THR A 292 SER A 301 1 ? 10 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            covale1 
_struct_conn.conn_type_id                  covale 
_struct_conn.pdbx_leaving_atom_flag        one 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            145 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           B 
_struct_conn.ptnr2_label_comp_id           UED 
_struct_conn.ptnr2_label_seq_id            . 
_struct_conn.ptnr2_label_atom_id           C21 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             145 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            UED 
_struct_conn.ptnr2_auth_seq_id             401 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               1.767 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      UED 
_pdbx_modification_feature.label_asym_id                      B 
_pdbx_modification_feature.label_seq_id                       . 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      145 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       UED 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        401 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       145 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               C21 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                CYS 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        UED 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Covalent chemical modification' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 73  ? LEU A 75  ? VAL A 73  LEU A 75  
AA1 2 PHE A 66  ? ALA A 70  ? PHE A 66  ALA A 70  
AA1 3 MET A 17  ? CYS A 22  ? MET A 17  CYS A 22  
AA1 4 THR A 25  ? LEU A 32  ? THR A 25  LEU A 32  
AA1 5 VAL A 35  ? PRO A 39  ? VAL A 35  PRO A 39  
AA1 6 VAL A 86  ? VAL A 91  ? VAL A 86  VAL A 91  
AA1 7 VAL A 77  ? GLN A 83  ? VAL A 77  GLN A 83  
AA2 1 TYR A 101 ? PHE A 103 ? TYR A 101 PHE A 103 
AA2 2 CYS A 156 ? VAL A 166 ? CYS A 156 VAL A 166 
AA2 3 VAL A 148 ? ASP A 153 ? VAL A 148 ASP A 153 
AA2 4 THR A 111 ? TYR A 118 ? THR A 111 TYR A 118 
AA2 5 SER A 121 ? ALA A 129 ? SER A 121 ALA A 129 
AA3 1 TYR A 101 ? PHE A 103 ? TYR A 101 PHE A 103 
AA3 2 CYS A 156 ? VAL A 166 ? CYS A 156 VAL A 166 
AA3 3 HIS A 172 ? THR A 175 ? HIS A 172 THR A 175 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL A 73  ? O VAL A 73  N ALA A 70  ? N ALA A 70  
AA1 2 3 O LEU A 67  ? O LEU A 67  N THR A 21  ? N THR A 21  
AA1 3 4 N VAL A 20  ? N VAL A 20  O LEU A 27  ? O LEU A 27  
AA1 4 5 N LEU A 30  ? N LEU A 30  O TYR A 37  ? O TYR A 37  
AA1 5 6 N CYS A 38  ? N CYS A 38  O LEU A 87  ? O LEU A 87  
AA1 6 7 O LYS A 90  ? O LYS A 90  N ILE A 78  ? N ILE A 78  
AA2 1 2 N LYS A 102 ? N LYS A 102 O PHE A 159 ? O PHE A 159 
AA2 2 3 O SER A 158 ? O SER A 158 N ASN A 151 ? N ASN A 151 
AA2 3 4 O PHE A 150 ? O PHE A 150 N SER A 113 ? N SER A 113 
AA2 4 5 N ALA A 116 ? N ALA A 116 O SER A 123 ? O SER A 123 
AA3 1 2 N LYS A 102 ? N LYS A 102 O PHE A 159 ? O PHE A 159 
AA3 2 3 N MET A 165 ? N MET A 165 O ALA A 173 ? O ALA A 173 
# 
_pdbx_entry_details.entry_id                   9BOD 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 33  ? ? 55.30   -134.58 
2 1 ASN A 84  ? ? 48.71   -119.49 
3 1 TYR A 154 ? ? 62.71   -100.08 
4 1 HIS A 164 ? ? -131.69 -36.60  
# 
_pdbx_molecule_features.prd_id    PRD_002495 
_pdbx_molecule_features.name      GC376 
_pdbx_molecule_features.type      Peptide-like 
_pdbx_molecule_features.class     Inhibitor 
_pdbx_molecule_features.details   ? 
# 
_pdbx_molecule.instance_id   1 
_pdbx_molecule.prd_id        PRD_002495 
_pdbx_molecule.asym_id       B 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 605 ? C HOH . 
2 1 A HOH 612 ? C HOH . 
3 1 A HOH 628 ? C HOH . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 -x,y,-z         
3 x+1/2,y+1/2,z   
4 -x+1/2,y+1/2,-z 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A PHE 305 ? A PHE 305 
2 1 Y 1 A GLN 306 ? A GLN 306 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
UED C7   C N N 372 
UED O8   O N N 373 
UED C9   C N N 374 
UED O10  O N N 375 
UED C1   C Y N 376 
UED C2   C Y N 377 
UED C3   C Y N 378 
UED C4   C Y N 379 
UED C5   C Y N 380 
UED C6   C Y N 381 
UED N11  N N N 382 
UED C12  C N S 383 
UED C17  C N N 384 
UED O18  O N N 385 
UED C13  C N N 386 
UED C14  C N N 387 
UED C15  C N N 388 
UED C16  C N N 389 
UED N19  N N N 390 
UED C20  C N S 391 
UED C21  C N N 392 
UED O22  O N N 393 
UED C24  C N N 394 
UED C25  C N S 395 
UED C26  C N N 396 
UED C27  C N N 397 
UED N28  N N N 398 
UED C29  C N N 399 
UED O30  O N N 400 
UED H1   H N N 401 
UED H2   H N N 402 
UED H3   H N N 403 
UED H4   H N N 404 
UED H5   H N N 405 
UED H6   H N N 406 
UED H7   H N N 407 
UED H8   H N N 408 
UED H9   H N N 409 
UED H10  H N N 410 
UED H11  H N N 411 
UED H12  H N N 412 
UED H13  H N N 413 
UED H14  H N N 414 
UED H15  H N N 415 
UED H16  H N N 416 
UED H17  H N N 417 
UED H18  H N N 418 
UED H19  H N N 419 
UED H20  H N N 420 
UED H21  H N N 421 
UED H22  H N N 422 
UED H23  H N N 423 
UED H24  H N N 424 
UED H25  H N N 425 
UED H26  H N N 426 
UED H27  H N N 427 
UED H28  H N N 428 
UED H29  H N N 429 
UED H30  H N N 430 
UED H31  H N N 431 
VAL N    N N N 432 
VAL CA   C N S 433 
VAL C    C N N 434 
VAL O    O N N 435 
VAL CB   C N N 436 
VAL CG1  C N N 437 
VAL CG2  C N N 438 
VAL OXT  O N N 439 
VAL H    H N N 440 
VAL H2   H N N 441 
VAL HA   H N N 442 
VAL HB   H N N 443 
VAL HG11 H N N 444 
VAL HG12 H N N 445 
VAL HG13 H N N 446 
VAL HG21 H N N 447 
VAL HG22 H N N 448 
VAL HG23 H N N 449 
VAL HXT  H N N 450 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
UED C16 C14  sing N N 358 
UED C3  C2   doub Y N 359 
UED C3  C4   sing Y N 360 
UED C2  C1   sing Y N 361 
UED C14 C13  sing N N 362 
UED C14 C15  sing N N 363 
UED C13 C12  sing N N 364 
UED C4  C5   doub Y N 365 
UED O8  C7   sing N N 366 
UED O8  C9   sing N N 367 
UED N11 C12  sing N N 368 
UED N11 C9   sing N N 369 
UED C1  C7   sing N N 370 
UED C1  C6   doub Y N 371 
UED O18 C17  doub N N 372 
UED C5  C6   sing Y N 373 
UED C12 C17  sing N N 374 
UED C9  O10  doub N N 375 
UED C17 N19  sing N N 376 
UED C26 C27  sing N N 377 
UED C26 C25  sing N N 378 
UED N19 C20  sing N N 379 
UED C20 C21  sing N N 380 
UED C20 C24  sing N N 381 
UED C27 N28  sing N N 382 
UED O22 C21  sing N N 383 
UED C25 C24  sing N N 384 
UED C25 C29  sing N N 385 
UED N28 C29  sing N N 386 
UED C29 O30  doub N N 387 
UED C7  H1   sing N N 388 
UED C7  H2   sing N N 389 
UED C2  H3   sing N N 390 
UED C3  H4   sing N N 391 
UED C4  H5   sing N N 392 
UED C5  H6   sing N N 393 
UED C6  H7   sing N N 394 
UED N11 H8   sing N N 395 
UED C12 H9   sing N N 396 
UED C13 H10  sing N N 397 
UED C13 H11  sing N N 398 
UED C14 H12  sing N N 399 
UED C15 H13  sing N N 400 
UED C15 H14  sing N N 401 
UED C15 H15  sing N N 402 
UED C16 H16  sing N N 403 
UED C16 H17  sing N N 404 
UED C16 H18  sing N N 405 
UED N19 H19  sing N N 406 
UED C20 H20  sing N N 407 
UED C24 H21  sing N N 408 
UED C24 H22  sing N N 409 
UED C25 H23  sing N N 410 
UED C26 H24  sing N N 411 
UED C26 H25  sing N N 412 
UED C27 H26  sing N N 413 
UED C27 H27  sing N N 414 
UED N28 H28  sing N N 415 
UED C21 H29  sing N N 416 
UED C21 H30  sing N N 417 
UED O22 H31  sing N N 418 
VAL N   CA   sing N N 419 
VAL N   H    sing N N 420 
VAL N   H2   sing N N 421 
VAL CA  C    sing N N 422 
VAL CA  CB   sing N N 423 
VAL CA  HA   sing N N 424 
VAL C   O    doub N N 425 
VAL C   OXT  sing N N 426 
VAL CB  CG1  sing N N 427 
VAL CB  CG2  sing N N 428 
VAL CB  HB   sing N N 429 
VAL CG1 HG11 sing N N 430 
VAL CG1 HG12 sing N N 431 
VAL CG1 HG13 sing N N 432 
VAL CG2 HG21 sing N N 433 
VAL CG2 HG22 sing N N 434 
VAL CG2 HG23 sing N N 435 
VAL OXT HXT  sing N N 436 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' 'P30 GM133893' 1 
'Department of Energy (DOE, United States)'                                                'United States' KP1607011      2 
'Other government'                                                                         ?               DE-SC0012704   3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7NF5 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'C 1 2 1' 
_space_group.name_Hall        'C 2y' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9BOD 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.008890 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.002059 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.019006 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.022343 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . SER A 1 1   ? -3.81129  -22.13626 38.84275  1.000 33.01379  ? 1   SER A N    1 
ATOM   2    C CA   . SER A 1 1   ? -2.97923  -20.95029 38.48848  1.000 37.37867  ? 1   SER A CA   1 
ATOM   3    C C    . SER A 1 1   ? -2.83139  -20.85314 36.97395  1.000 35.58426  ? 1   SER A C    1 
ATOM   4    O O    . SER A 1 1   ? -2.49812  -21.83394 36.31045  1.000 31.60375  ? 1   SER A O    1 
ATOM   5    C CB   . SER A 1 1   ? -1.60660  -21.03505 39.16006  1.000 37.89693  ? 1   SER A CB   1 
ATOM   6    O OG   . SER A 1 1   ? -0.82769  -22.08348 38.61310  1.000 45.02755  ? 1   SER A OG   1 
ATOM   7    H H1   . SER A 1 1   ? -3.42191  -22.87467 38.53417  1.000 39.60359  ? 1   SER A H1   1 
ATOM   8    H H2   . SER A 1 1   ? -3.88982  -22.18988 39.72765  1.000 39.60359  ? 1   SER A H2   1 
ATOM   9    H H3   . SER A 1 1   ? -4.61864  -22.05190 38.47782  1.000 39.60359  ? 1   SER A H3   1 
ATOM   10   H HA   . SER A 1 1   ? -3.40654  -20.14046 38.80862  1.000 44.84145  ? 1   SER A HA   1 
ATOM   11   H HB2  . SER A 1 1   ? -1.13988  -20.19524 39.02663  1.000 45.46336  ? 1   SER A HB2  1 
ATOM   12   H HB3  . SER A 1 1   ? -1.73093  -21.19852 40.10806  1.000 45.46336  ? 1   SER A HB3  1 
ATOM   13   H HG   . SER A 1 1   ? -1.27817  -22.79195 38.58585  1.000 54.02011  ? 1   SER A HG   1 
ATOM   14   N N    . GLY A 1 2   ? -3.08212  -19.66905 36.43246  1.000 36.26468  ? 2   GLY A N    1 
ATOM   15   C CA   . GLY A 1 2   ? -3.08367  -19.47413 35.00132  1.000 31.47026  ? 2   GLY A CA   1 
ATOM   16   C C    . GLY A 1 2   ? -4.39015  -19.91828 34.36681  1.000 32.02668  ? 2   GLY A C    1 
ATOM   17   O O    . GLY A 1 2   ? -5.18642  -20.65438 34.94640  1.000 32.70279  ? 2   GLY A O    1 
ATOM   18   H H    . GLY A 1 2   ? -3.25580  -18.95735 36.88291  1.000 43.50466  ? 2   GLY A H    1 
ATOM   19   H HA2  . GLY A 1 2   ? -2.95040  -18.53382 34.80395  1.000 37.75135  ? 2   GLY A HA2  1 
ATOM   20   H HA3  . GLY A 1 2   ? -2.36058  -19.98545 34.60560  1.000 37.75135  ? 2   GLY A HA3  1 
ATOM   21   N N    . PHE A 1 3   ? -4.60638  -19.45433 33.14037  1.000 32.53969  ? 3   PHE A N    1 
ATOM   22   C CA   . PHE A 1 3   ? -5.84805  -19.74066 32.43107  1.000 31.11327  ? 3   PHE A CA   1 
ATOM   23   C C    . PHE A 1 3   ? -5.54686  -19.73498 30.94186  1.000 32.38968  ? 3   PHE A C    1 
ATOM   24   O O    . PHE A 1 3   ? -5.03540  -18.74098 30.41592  1.000 30.69387  ? 3   PHE A O    1 
ATOM   25   C CB   . PHE A 1 3   ? -6.93312  -18.71810 32.78066  1.000 32.52437  ? 3   PHE A CB   1 
ATOM   26   C CG   . PHE A 1 3   ? -8.32492  -19.17697 32.45135  1.000 32.10394  ? 3   PHE A CG   1 
ATOM   27   C CD1  . PHE A 1 3   ? -9.00751  -20.03096 33.30260  1.000 33.93856  ? 3   PHE A CD1  1 
ATOM   28   C CD2  . PHE A 1 3   ? -8.94999  -18.75507 31.29113  1.000 32.00389  ? 3   PHE A CD2  1 
ATOM   29   C CE1  . PHE A 1 3   ? -10.28961 -20.45614 33.00123  1.000 33.36916  ? 3   PHE A CE1  1 
ATOM   30   C CE2  . PHE A 1 3   ? -10.22985 -19.17462 30.98615  1.000 34.15354  ? 3   PHE A CE2  1 
ATOM   31   C CZ   . PHE A 1 3   ? -10.90052 -20.02715 31.84287  1.000 32.03467  ? 3   PHE A CZ   1 
ATOM   32   H H    . PHE A 1 3   ? -4.04936  -18.97135 32.69758  1.000 39.03467  ? 3   PHE A H    1 
ATOM   33   H HA   . PHE A 1 3   ? -6.17714  -20.61920 32.67760  1.000 37.32296  ? 3   PHE A HA   1 
ATOM   34   H HB2  . PHE A 1 3   ? -6.89791  -18.53923 33.73337  1.000 39.01629  ? 3   PHE A HB2  1 
ATOM   35   H HB3  . PHE A 1 3   ? -6.76484  -17.90236 32.28351  1.000 39.01629  ? 3   PHE A HB3  1 
ATOM   36   H HD1  . PHE A 1 3   ? -8.59921  -20.32193 34.08587  1.000 40.71332  ? 3   PHE A HD1  1 
ATOM   37   H HD2  . PHE A 1 3   ? -8.50316  -18.18254 30.71023  1.000 38.39171  ? 3   PHE A HD2  1 
ATOM   38   H HE1  . PHE A 1 3   ? -10.73801 -21.03028 33.57934  1.000 40.03004  ? 3   PHE A HE1  1 
ATOM   39   H HE2  . PHE A 1 3   ? -10.64059 -18.88351 30.20420  1.000 40.97129  ? 3   PHE A HE2  1 
ATOM   40   H HZ   . PHE A 1 3   ? -11.76224 -20.31064 31.63800  1.000 38.42865  ? 3   PHE A HZ   1 
ATOM   41   N N    . ARG A 1 4   ? -5.86195  -20.84308 30.27483  1.000 34.09520  ? 4   ARG A N    1 
ATOM   42   C CA   . ARG A 1 4   ? -5.47186  -21.07126 28.89359  1.000 33.57214  ? 4   ARG A CA   1 
ATOM   43   C C    . ARG A 1 4   ? -6.64559  -21.64565 28.11993  1.000 33.37744  ? 4   ARG A C    1 
ATOM   44   O O    . ARG A 1 4   ? -7.47110  -22.37187 28.67475  1.000 31.11223  ? 4   ARG A O    1 
ATOM   45   C CB   . ARG A 1 4   ? -4.29039  -22.04616 28.81426  1.000 33.68340  ? 4   ARG A CB   1 
ATOM   46   C CG   . ARG A 1 4   ? -2.99854  -21.52513 29.41772  1.000 35.51357  ? 4   ARG A CG   1 
ATOM   47   C CD   . ARG A 1 4   ? -2.42437  -20.36868 28.61773  1.000 41.57537  ? 4   ARG A CD   1 
ATOM   48   N NE   . ARG A 1 4   ? -2.44886  -20.62823 27.18254  1.000 39.25525  ? 4   ARG A NE   1 
ATOM   49   C CZ   . ARG A 1 4   ? -1.62213  -21.44900 26.54671  1.000 41.77064  ? 4   ARG A CZ   1 
ATOM   50   N NH1  . ARG A 1 4   ? -0.67467  -22.11755 27.19041  1.000 48.30135  ? 4   ARG A NH1  1 
ATOM   51   N NH2  . ARG A 1 4   ? -1.75137  -21.60652 25.22974  1.000 44.57583  ? 4   ARG A NH2  1 
ATOM   52   H H    . ARG A 1 4   ? -6.31323  -21.49241 30.61293  1.000 40.90129  ? 4   ARG A H    1 
ATOM   53   H HA   . ARG A 1 4   ? -5.22140  -20.22847 28.48387  1.000 40.27361  ? 4   ARG A HA   1 
ATOM   54   H HB2  . ARG A 1 4   ? -4.52815  -22.85811 29.28872  1.000 40.40713  ? 4   ARG A HB2  1 
ATOM   55   H HB3  . ARG A 1 4   ? -4.11747  -22.24585 27.88092  1.000 40.40713  ? 4   ARG A HB3  1 
ATOM   56   H HG2  . ARG A 1 4   ? -3.17015  -21.21360 30.32016  1.000 42.60332  ? 4   ARG A HG2  1 
ATOM   57   H HG3  . ARG A 1 4   ? -2.34191  -22.23893 29.43240  1.000 42.60332  ? 4   ARG A HG3  1 
ATOM   58   H HD2  . ARG A 1 4   ? -2.94844  -19.57079 28.78981  1.000 49.87749  ? 4   ARG A HD2  1 
ATOM   59   H HD3  . ARG A 1 4   ? -1.50273  -20.22392 28.88327  1.000 49.87749  ? 4   ARG A HD3  1 
ATOM   60   H HE   . ARG A 1 4   ? -3.04275  -20.21928 26.71388  1.000 47.09334  ? 4   ARG A HE   1 
ATOM   61   H HH11 . ARG A 1 4   ? -0.58476  -22.02454 28.04062  1.000 57.94867  ? 4   ARG A HH11 1 
ATOM   62   H HH12 . ARG A 1 4   ? -0.15021  -22.64406 26.75759  1.000 57.94867  ? 4   ARG A HH12 1 
ATOM   63   H HH21 . ARG A 1 4   ? -2.36415  -21.17926 24.80366  1.000 53.47804  ? 4   ARG A HH21 1 
ATOM   64   H HH22 . ARG A 1 4   ? -1.22200  -22.13544 24.80594  1.000 53.47804  ? 4   ARG A HH22 1 
ATOM   65   N N    . LYS A 1 5   ? -6.71113  -21.32056 26.82980  1.000 30.25230  ? 5   LYS A N    1 
ATOM   66   C CA   . LYS A 1 5   ? -7.64711  -21.99840 25.94424  1.000 30.90106  ? 5   LYS A CA   1 
ATOM   67   C C    . LYS A 1 5   ? -7.18305  -23.44080 25.76872  1.000 31.58470  ? 5   LYS A C    1 
ATOM   68   O O    . LYS A 1 5   ? -6.08122  -23.69348 25.27107  1.000 32.24288  ? 5   LYS A O    1 
ATOM   69   C CB   . LYS A 1 5   ? -7.74167  -21.28244 24.60314  1.000 33.03683  ? 5   LYS A CB   1 
ATOM   70   C CG   . LYS A 1 5   ? -8.96462  -21.68175 23.80625  1.000 33.78846  ? 5   LYS A CG   1 
ATOM   71   C CD   . LYS A 1 5   ? -9.20396  -20.75124 22.63482  1.000 42.54827  ? 5   LYS A CD   1 
ATOM   72   C CE   . LYS A 1 5   ? -10.10241 -19.58752 23.02023  1.000 43.49081  ? 5   LYS A CE   1 
ATOM   73   N NZ   . LYS A 1 5   ? -10.45301 -18.76057 21.83216  1.000 49.89471  ? 5   LYS A NZ   1 
ATOM   74   H H    . LYS A 1 5   ? -6.22921  -20.71801 26.44993  1.000 36.28981  ? 5   LYS A H    1 
ATOM   75   H HA   . LYS A 1 5   ? -8.53693  -21.99150 26.33032  1.000 37.06832  ? 5   LYS A HA   1 
ATOM   76   H HB2  . LYS A 1 5   ? -7.78482  -20.32603 24.75907  1.000 39.63125  ? 5   LYS A HB2  1 
ATOM   77   H HB3  . LYS A 1 5   ? -6.95678  -21.49745 24.07530  1.000 39.63125  ? 5   LYS A HB3  1 
ATOM   78   H HG2  . LYS A 1 5   ? -8.84173  -22.57954 23.46016  1.000 40.53320  ? 5   LYS A HG2  1 
ATOM   79   H HG3  . LYS A 1 5   ? -9.74502  -21.65191 24.38157  1.000 40.53320  ? 5   LYS A HG3  1 
ATOM   80   H HD2  . LYS A 1 5   ? -8.35535  -20.39312 22.33068  1.000 51.04497  ? 5   LYS A HD2  1 
ATOM   81   H HD3  . LYS A 1 5   ? -9.63310  -21.24259 21.91697  1.000 51.04497  ? 5   LYS A HD3  1 
ATOM   82   H HE2  . LYS A 1 5   ? -10.92307 -19.92895 23.40862  1.000 52.17601  ? 5   LYS A HE2  1 
ATOM   83   H HE3  . LYS A 1 5   ? -9.64182  -19.02332 23.66088  1.000 52.17601  ? 5   LYS A HE3  1 
ATOM   84   H HZ1  . LYS A 1 5   ? -11.04509 -19.19084 21.32579  1.000 59.86069  ? 5   LYS A HZ1  1 
ATOM   85   H HZ2  . LYS A 1 5   ? -10.80518 -17.98612 22.09353  1.000 59.86069  ? 5   LYS A HZ2  1 
ATOM   86   H HZ3  . LYS A 1 5   ? -9.72373  -18.59770 21.34871  1.000 59.86069  ? 5   LYS A HZ3  1 
ATOM   87   N N    . MET A 1 6   ? -8.01763  -24.38405 26.18846  1.000 28.57198  ? 6   MET A N    1 
ATOM   88   C CA   . MET A 1 6   ? -7.57735  -25.74965 26.42901  1.000 29.16372  ? 6   MET A CA   1 
ATOM   89   C C    . MET A 1 6   ? -8.57839  -26.71865 25.82727  1.000 27.86213  ? 6   MET A C    1 
ATOM   90   O O    . MET A 1 6   ? -9.78868  -26.54901 25.99339  1.000 31.22866  ? 6   MET A O    1 
ATOM   91   C CB   . MET A 1 6   ? -7.42369  -25.97985 27.93646  1.000 29.53131  ? 6   MET A CB   1 
ATOM   92   C CG   . MET A 1 6   ? -7.07100  -27.38481 28.36785  1.000 33.67607  ? 6   MET A CG   1 
ATOM   93   S SD   . MET A 1 6   ? -7.13727  -27.51916 30.17157  1.000 38.09876  ? 6   MET A SD   1 
ATOM   94   C CE   . MET A 1 6   ? -6.24757  -26.05455 30.68850  1.000 32.19938  ? 6   MET A CE   1 
ATOM   95   H H    . MET A 1 6   ? -8.85378  -24.25493 26.34264  1.000 34.27342  ? 6   MET A H    1 
ATOM   96   H HA   . MET A 1 6   ? -6.72199  -25.90935 26.00034  1.000 34.98350  ? 6   MET A HA   1 
ATOM   97   H HB2  . MET A 1 6   ? -6.71932  -25.39693 28.26043  1.000 35.42462  ? 6   MET A HB2  1 
ATOM   98   H HB3  . MET A 1 6   ? -8.26459  -25.75318 28.36355  1.000 35.42462  ? 6   MET A HB3  1 
ATOM   99   H HG2  . MET A 1 6   ? -7.70495  -28.01185 27.98596  1.000 40.39833  ? 6   MET A HG2  1 
ATOM   100  H HG3  . MET A 1 6   ? -6.17243  -27.60043 28.07291  1.000 40.39833  ? 6   MET A HG3  1 
ATOM   101  H HE1  . MET A 1 6   ? -6.81292  -25.27783 30.55440  1.000 38.62631  ? 6   MET A HE1  1 
ATOM   102  H HE2  . MET A 1 6   ? -6.01872  -26.13897 31.62733  1.000 38.62631  ? 6   MET A HE2  1 
ATOM   103  H HE3  . MET A 1 6   ? -5.44014  -25.97163 30.15738  1.000 38.62631  ? 6   MET A HE3  1 
ATOM   104  N N    . ALA A 1 7   ? -8.07144  -27.72811 25.13047  1.000 27.73502  ? 7   ALA A N    1 
ATOM   105  C CA   . ALA A 1 7   ? -8.90729  -28.71200 24.46424  1.000 27.57854  ? 7   ALA A CA   1 
ATOM   106  C C    . ALA A 1 7   ? -8.96157  -30.00617 25.26205  1.000 26.75367  ? 7   ALA A C    1 
ATOM   107  O O    . ALA A 1 7   ? -8.05417  -30.32228 26.03734  1.000 26.70788  ? 7   ALA A O    1 
ATOM   108  C CB   . ALA A 1 7   ? -8.38345  -29.00449 23.05854  1.000 26.03922  ? 7   ALA A CB   1 
ATOM   109  H H    . ALA A 1 7   ? -7.22861  -27.86525 25.02828  1.000 33.26907  ? 7   ALA A H    1 
ATOM   110  H HA   . ALA A 1 7   ? -9.80933  -28.36222 24.39435  1.000 33.08129  ? 7   ALA A HA   1 
ATOM   111  H HB1  . ALA A 1 7   ? -7.46390  -29.30690 23.12078  1.000 31.23411  ? 7   ALA A HB1  1 
ATOM   112  H HB2  . ALA A 1 7   ? -8.93205  -29.69484 22.65438  1.000 31.23411  ? 7   ALA A HB2  1 
ATOM   113  H HB3  . ALA A 1 7   ? -8.42967  -28.19303 22.52911  1.000 31.23411  ? 7   ALA A HB3  1 
ATOM   114  N N    . PHE A 1 8   ? -10.04271 -30.75490 25.06903  1.000 26.32964  ? 8   PHE A N    1 
ATOM   115  C CA   . PHE A 1 8   ? -10.12518 -32.06984 25.67329  1.000 29.31463  ? 8   PHE A CA   1 
ATOM   116  C C    . PHE A 1 8   ? -8.98697  -32.93731 25.14080  1.000 26.47792  ? 8   PHE A C    1 
ATOM   117  O O    . PHE A 1 8   ? -8.49323  -32.71407 24.03190  1.000 27.73255  ? 8   PHE A O    1 
ATOM   118  C CB   . PHE A 1 8   ? -11.46229 -32.73803 25.36520  1.000 29.98073  ? 8   PHE A CB   1 
ATOM   119  C CG   . PHE A 1 8   ? -12.64203 -32.07615 26.01284  1.000 30.51154  ? 8   PHE A CG   1 
ATOM   120  C CD1  . PHE A 1 8   ? -13.00704 -32.39298 27.30924  1.000 34.74055  ? 8   PHE A CD1  1 
ATOM   121  C CD2  . PHE A 1 8   ? -13.39790 -31.14860 25.31734  1.000 34.63132  ? 8   PHE A CD2  1 
ATOM   122  C CE1  . PHE A 1 8   ? -14.10089 -31.78993 27.90234  1.000 38.92763  ? 8   PHE A CE1  1 
ATOM   123  C CE2  . PHE A 1 8   ? -14.48928 -30.54433 25.90347  1.000 35.34970  ? 8   PHE A CE2  1 
ATOM   124  C CZ   . PHE A 1 8   ? -14.84205 -30.86602 27.19853  1.000 38.49992  ? 8   PHE A CZ   1 
ATOM   125  H H    . PHE A 1 8   ? -10.72686 -30.52582 24.60099  1.000 31.58261  ? 8   PHE A H    1 
ATOM   126  H HA   . PHE A 1 8   ? -10.05132 -31.98841 26.63704  1.000 35.16460  ? 8   PHE A HA   1 
ATOM   127  H HB2  . PHE A 1 8   ? -11.60453 -32.72010 24.40585  1.000 35.96393  ? 8   PHE A HB2  1 
ATOM   128  H HB3  . PHE A 1 8   ? -11.43046 -33.65539 25.67879  1.000 35.96393  ? 8   PHE A HB3  1 
ATOM   129  H HD1  . PHE A 1 8   ? -12.51134 -33.01829 27.78690  1.000 41.67571  ? 8   PHE A HD1  1 
ATOM   130  H HD2  . PHE A 1 8   ? -13.16651 -30.93028 24.44344  1.000 41.54463  ? 8   PHE A HD2  1 
ATOM   131  H HE1  . PHE A 1 8   ? -14.33605 -32.00772 28.77536  1.000 46.70020  ? 8   PHE A HE1  1 
ATOM   132  H HE2  . PHE A 1 8   ? -14.98756 -29.92035 25.42674  1.000 42.40668  ? 8   PHE A HE2  1 
ATOM   133  H HZ   . PHE A 1 8   ? -15.57863 -30.45992 27.59529  1.000 46.18695  ? 8   PHE A HZ   1 
ATOM   134  N N    . PRO A 1 9   ? -8.54675  -33.93019 25.90490  1.000 29.52994  ? 9   PRO A N    1 
ATOM   135  C CA   . PRO A 1 9   ? -7.59531  -34.89912 25.34963  1.000 27.42294  ? 9   PRO A CA   1 
ATOM   136  C C    . PRO A 1 9   ? -8.22518  -35.62336 24.16921  1.000 27.13320  ? 9   PRO A C    1 
ATOM   137  O O    . PRO A 1 9   ? -9.39917  -35.99409 24.20292  1.000 25.08187  ? 9   PRO A O    1 
ATOM   138  C CB   . PRO A 1 9   ? -7.31344  -35.84290 26.52306  1.000 26.33590  ? 9   PRO A CB   1 
ATOM   139  C CG   . PRO A 1 9   ? -7.75733  -35.09145 27.75119  1.000 30.30877  ? 9   PRO A CG   1 
ATOM   140  C CD   . PRO A 1 9   ? -8.89756  -34.23688 27.30313  1.000 27.56221  ? 9   PRO A CD   1 
ATOM   141  H HA   . PRO A 1 9   ? -6.76423  -34.47633 25.08231  1.000 32.89458  ? 9   PRO A HA   1 
ATOM   142  H HB2  . PRO A 1 9   ? -7.82157  -36.66218 26.41592  1.000 31.59012  ? 9   PRO A HB2  1 
ATOM   143  H HB3  . PRO A 1 9   ? -6.36528  -36.04349 26.56372  1.000 31.59012  ? 9   PRO A HB3  1 
ATOM   144  H HG2  . PRO A 1 9   ? -8.04307  -35.71766 28.43464  1.000 36.35757  ? 9   PRO A HG2  1 
ATOM   145  H HG3  . PRO A 1 9   ? -7.02772  -34.54628 28.08489  1.000 36.35757  ? 9   PRO A HG3  1 
ATOM   146  H HD2  . PRO A 1 9   ? -9.73561  -34.72286 27.35205  1.000 33.06169  ? 9   PRO A HD2  1 
ATOM   147  H HD3  . PRO A 1 9   ? -8.95275  -33.42620 27.83288  1.000 33.06169  ? 9   PRO A HD3  1 
ATOM   148  N N    . SER A 1 10  ? -7.43060  -35.81879 23.11747  1.000 26.38611  ? 10  SER A N    1 
ATOM   149  C CA   . SER A 1 10  ? -7.94514  -36.24165 21.82145  1.000 25.59946  ? 10  SER A CA   1 
ATOM   150  C C    . SER A 1 10  ? -7.83099  -37.74091 21.57396  1.000 26.26536  ? 10  SER A C    1 
ATOM   151  O O    . SER A 1 10  ? -8.18768  -38.20039 20.48439  1.000 26.38946  ? 10  SER A O    1 
ATOM   152  C CB   . SER A 1 10  ? -7.21054  -35.48570 20.70803  1.000 26.25831  ? 10  SER A CB   1 
ATOM   153  O OG   . SER A 1 10  ? -5.83185  -35.80664 20.70540  1.000 27.84390  ? 10  SER A OG   1 
ATOM   154  H H    . SER A 1 10  ? -6.57757  -35.71057 23.13275  1.000 31.65037  ? 10  SER A H    1 
ATOM   155  H HA   . SER A 1 10  ? -8.88818  -36.01797 21.78218  1.000 30.70639  ? 10  SER A HA   1 
ATOM   156  H HB2  . SER A 1 10  ? -7.59395  -35.73348 19.85217  1.000 31.49702  ? 10  SER A HB2  1 
ATOM   157  H HB3  . SER A 1 10  ? -7.31238  -34.53211 20.85359  1.000 31.49702  ? 10  SER A HB3  1 
ATOM   158  H HG   . SER A 1 10  ? -5.46694  -35.50056 20.01348  1.000 33.39973  ? 10  SER A HG   1 
ATOM   159  N N    . GLY A 1 11  ? -7.36505  -38.51608 22.55400  1.000 27.19096  ? 11  GLY A N    1 
ATOM   160  C CA   . GLY A 1 11  ? -7.05753  -39.91482 22.29468  1.000 27.65994  ? 11  GLY A CA   1 
ATOM   161  C C    . GLY A 1 11  ? -8.25349  -40.71767 21.81649  1.000 27.09314  ? 11  GLY A C    1 
ATOM   162  O O    . GLY A 1 11  ? -8.15353  -41.49070 20.86225  1.000 27.70353  ? 11  GLY A O    1 
ATOM   163  H H    . GLY A 1 11  ? -7.22155  -38.25922 23.36211  1.000 32.61620  ? 11  GLY A H    1 
ATOM   164  H HA2  . GLY A 1 11  ? -6.36836  -39.96684 21.61406  1.000 33.17897  ? 11  GLY A HA2  1 
ATOM   165  H HA3  . GLY A 1 11  ? -6.72739  -40.32317 23.11025  1.000 33.17897  ? 11  GLY A HA3  1 
ATOM   166  N N    . LYS A 1 12  ? -9.40071  -40.55752 22.48199  1.000 26.05630  ? 12  LYS A N    1 
ATOM   167  C CA   . LYS A 1 12  ? -10.57217 -41.34878 22.11982  1.000 26.59918  ? 12  LYS A CA   1 
ATOM   168  C C    . LYS A 1 12  ? -11.02888 -41.07028 20.69285  1.000 26.20562  ? 12  LYS A C    1 
ATOM   169  O O    . LYS A 1 12  ? -11.63873 -41.93869 20.05950  1.000 27.92189  ? 12  LYS A O    1 
ATOM   170  C CB   . LYS A 1 12  ? -11.71582 -41.07127 23.09537  1.000 28.01262  ? 12  LYS A CB   1 
ATOM   171  C CG   . LYS A 1 12  ? -11.47212 -41.58758 24.49839  1.000 31.09980  ? 12  LYS A CG   1 
ATOM   172  C CD   . LYS A 1 12  ? -12.57061 -41.12679 25.44201  1.000 39.62858  ? 12  LYS A CD   1 
ATOM   173  C CE   . LYS A 1 12  ? -12.26385 -41.49126 26.88753  1.000 48.21775  ? 12  LYS A CE   1 
ATOM   174  N NZ   . LYS A 1 12  ? -11.90096 -42.92672 27.03759  1.000 53.14482  ? 12  LYS A NZ   1 
ATOM   175  H H    . LYS A 1 12  ? -9.52240  -40.00871 23.13283  1.000 31.25460  ? 12  LYS A H    1 
ATOM   176  H HA   . LYS A 1 12  ? -10.33688 -42.28774 22.18212  1.000 31.90606  ? 12  LYS A HA   1 
ATOM   177  H HB2  . LYS A 1 12  ? -11.84839 -40.11213 23.15338  1.000 33.60219  ? 12  LYS A HB2  1 
ATOM   178  H HB3  . LYS A 1 12  ? -12.52001 -41.49767 22.76017  1.000 33.60219  ? 12  LYS A HB3  1 
ATOM   179  H HG2  . LYS A 1 12  ? -11.46115 -42.55748 24.48924  1.000 37.30681  ? 12  LYS A HG2  1 
ATOM   180  H HG3  . LYS A 1 12  ? -10.62379 -41.24929 24.82520  1.000 37.30681  ? 12  LYS A HG3  1 
ATOM   181  H HD2  . LYS A 1 12  ? -12.65867 -40.16253 25.38420  1.000 47.54134  ? 12  LYS A HD2  1 
ATOM   182  H HD3  . LYS A 1 12  ? -13.40609 -41.55179 25.19253  1.000 47.54134  ? 12  LYS A HD3  1 
ATOM   183  H HE2  . LYS A 1 12  ? -11.51745 -40.95622 27.19982  1.000 57.84835  ? 12  LYS A HE2  1 
ATOM   184  H HE3  . LYS A 1 12  ? -13.04707 -41.31852 27.43308  1.000 57.84835  ? 12  LYS A HE3  1 
ATOM   185  H HZ1  . LYS A 1 12  ? -11.86534 -43.14313 27.90014  1.000 63.76083  ? 12  LYS A HZ1  1 
ATOM   186  H HZ2  . LYS A 1 12  ? -12.50905 -43.43796 26.63641  1.000 63.76083  ? 12  LYS A HZ2  1 
ATOM   187  H HZ3  . LYS A 1 12  ? -11.10581 -43.07989 26.66830  1.000 63.76083  ? 12  LYS A HZ3  1 
ATOM   188  N N    . VAL A 1 13  ? -10.75250 -39.87418 20.17600  1.000 24.31958  ? 13  VAL A N    1 
ATOM   189  C CA   . VAL A 1 13  ? -11.19576 -39.49912 18.83799  1.000 23.91153  ? 13  VAL A CA   1 
ATOM   190  C C    . VAL A 1 13  ? -10.16251 -39.88267 17.78505  1.000 25.23938  ? 13  VAL A C    1 
ATOM   191  O O    . VAL A 1 13  ? -10.52942 -40.23334 16.66041  1.000 24.00485  ? 13  VAL A O    1 
ATOM   192  C CB   . VAL A 1 13  ? -11.49899 -37.98932 18.80213  1.000 26.00532  ? 13  VAL A CB   1 
ATOM   193  C CG1  . VAL A 1 13  ? -11.88148 -37.53825 17.40261  1.000 22.81819  ? 13  VAL A CG1  1 
ATOM   194  C CG2  . VAL A 1 13  ? -12.60943 -37.65840 19.78395  1.000 24.48859  ? 13  VAL A CG2  1 
ATOM   195  H H    . VAL A 1 13  ? -10.30805 -39.25991 20.58189  1.000 29.17055  ? 13  VAL A H    1 
ATOM   196  H HA   . VAL A 1 13  ? -12.01399 -39.97342 18.62250  1.000 28.68089  ? 13  VAL A HA   1 
ATOM   197  H HB   . VAL A 1 13  ? -10.69742 -37.50711 19.05874  1.000 31.19343  ? 13  VAL A HB   1 
ATOM   198  H HG11 . VAL A 1 13  ? -12.64780 -38.05227 17.10353  1.000 27.36888  ? 13  VAL A HG11 1 
ATOM   199  H HG12 . VAL A 1 13  ? -12.10452 -36.59450 17.42490  1.000 27.36888  ? 13  VAL A HG12 1 
ATOM   200  H HG13 . VAL A 1 13  ? -11.13064 -37.68671 16.80671  1.000 27.36888  ? 13  VAL A HG13 1 
ATOM   201  H HG21 . VAL A 1 13  ? -12.84876 -36.72344 19.68663  1.000 29.37335  ? 13  VAL A HG21 1 
ATOM   202  H HG22 . VAL A 1 13  ? -13.37792 -38.21828 19.59199  1.000 29.37335  ? 13  VAL A HG22 1 
ATOM   203  H HG23 . VAL A 1 13  ? -12.29429 -37.82704 20.68570  1.000 29.37335  ? 13  VAL A HG23 1 
ATOM   204  N N    . GLU A 1 14  ? -8.87456  -39.80137 18.12381  1.000 24.13634  ? 14  GLU A N    1 
ATOM   205  C CA   . GLU A 1 14  ? -7.82708  -40.22208 17.20015  1.000 25.25975  ? 14  GLU A CA   1 
ATOM   206  C C    . GLU A 1 14  ? -8.11870  -41.60507 16.62917  1.000 25.20913  ? 14  GLU A C    1 
ATOM   207  O O    . GLU A 1 14  ? -7.99575  -41.83008 15.41876  1.000 25.68375  ? 14  GLU A O    1 
ATOM   208  C CB   . GLU A 1 14  ? -6.47298  -40.20837 17.91744  1.000 25.09042  ? 14  GLU A CB   1 
ATOM   209  C CG   . GLU A 1 14  ? -5.94883  -38.81183 18.23602  1.000 27.67629  ? 14  GLU A CG   1 
ATOM   210  C CD   . GLU A 1 14  ? -4.72208  -38.83165 19.13181  1.000 26.77643  ? 14  GLU A CD   1 
ATOM   211  O OE1  . GLU A 1 14  ? -3.86520  -39.71861 18.95015  1.000 30.26667  ? 14  GLU A OE1  1 
ATOM   212  O OE2  . GLU A 1 14  ? -4.62382  -37.96452 20.02503  1.000 28.47365  ? 14  GLU A OE2  1 
ATOM   213  H H    . GLU A 1 14  ? -8.58408  -39.50781 18.87816  1.000 28.95065  ? 14  GLU A H    1 
ATOM   214  H HA   . GLU A 1 14  ? -7.78419  -39.59710 16.45956  1.000 30.29875  ? 14  GLU A HA   1 
ATOM   215  H HB2  . GLU A 1 14  ? -6.56130  -40.68797 18.75594  1.000 30.09555  ? 14  GLU A HB2  1 
ATOM   216  H HB3  . GLU A 1 14  ? -5.81799  -40.64667 17.35195  1.000 30.09555  ? 14  GLU A HB3  1 
ATOM   217  H HG2  . GLU A 1 14  ? -5.70754  -38.36866 17.40760  1.000 33.19859  ? 14  GLU A HG2  1 
ATOM   218  H HG3  . GLU A 1 14  ? -6.64345  -38.31006 18.69058  1.000 33.19859  ? 14  GLU A HG3  1 
ATOM   219  N N    . GLY A 1 15  ? -8.52750  -42.54023 17.48474  1.000 23.87147  ? 15  GLY A N    1 
ATOM   220  C CA   . GLY A 1 15  ? -8.79402  -43.90009 17.05846  1.000 26.25141  ? 15  GLY A CA   1 
ATOM   221  C C    . GLY A 1 15  ? -10.00897 -44.06707 16.16905  1.000 24.78054  ? 15  GLY A C    1 
ATOM   222  O O    . GLY A 1 15  ? -10.24767 -45.18129 15.69037  1.000 26.35081  ? 15  GLY A O    1 
ATOM   223  H H    . GLY A 1 15  ? -8.65776  -42.40610 18.32417  1.000 28.63281  ? 15  GLY A H    1 
ATOM   224  H HA2  . GLY A 1 15  ? -8.02329  -44.22832 16.56945  1.000 31.48873  ? 15  GLY A HA2  1 
ATOM   225  H HA3  . GLY A 1 15  ? -8.92682  -44.45125 17.84554  1.000 31.48873  ? 15  GLY A HA3  1 
ATOM   226  N N    . CYS A 1 16  ? -10.77742 -43.00564 15.94162  1.000 25.49520  ? 16  CYS A N    1 
ATOM   227  C CA   . CYS A 1 16  ? -11.96357 -43.06787 15.09618  1.000 23.51606  ? 16  CYS A CA   1 
ATOM   228  C C    . CYS A 1 16  ? -11.75510 -42.43196 13.72765  1.000 24.73271  ? 16  CYS A C    1 
ATOM   229  O O    . CYS A 1 16  ? -12.67601 -42.45291 12.90363  1.000 22.40864  ? 16  CYS A O    1 
ATOM   230  C CB   . CYS A 1 16  ? -13.14611 -42.38477 15.78600  1.000 24.60826  ? 16  CYS A CB   1 
ATOM   231  S SG   . CYS A 1 16  ? -13.59707 -43.07429 17.40095  1.000 27.06678  ? 16  CYS A SG   1 
ATOM   232  H H    . CYS A 1 16  ? -10.62902 -42.22558 16.27190  1.000 30.58129  ? 16  CYS A H    1 
ATOM   233  H HA   . CYS A 1 16  ? -12.18810 -44.00228 14.96436  1.000 28.20632  ? 16  CYS A HA   1 
ATOM   234  H HB2  . CYS A 1 16  ? -12.92414 -41.45019 15.92086  1.000 29.51696  ? 16  CYS A HB2  1 
ATOM   235  H HB3  . CYS A 1 16  ? -13.92292 -42.46151 15.21017  1.000 29.51696  ? 16  CYS A HB3  1 
ATOM   236  H HG   . CYS A 1 16  ? -13.87329 -44.23437 17.26709  1.000 32.46718  ? 16  CYS A HG   1 
ATOM   237  N N    . MET A 1 17  ? -10.57942 -41.87169 13.46351  1.000 23.17832  ? 17  MET A N    1 
ATOM   238  C CA   . MET A 1 17  ? -10.34567 -41.11850 12.24223  1.000 23.43522  ? 17  MET A CA   1 
ATOM   239  C C    . MET A 1 17  ? -9.80590  -42.03658 11.15178  1.000 25.76414  ? 17  MET A C    1 
ATOM   240  O O    . MET A 1 17  ? -8.86851  -42.80568 11.38424  1.000 25.82096  ? 17  MET A O    1 
ATOM   241  C CB   . MET A 1 17  ? -9.37072  -39.97092 12.50352  1.000 25.84218  ? 17  MET A CB   1 
ATOM   242  C CG   . MET A 1 17  ? -9.85706  -38.99007 13.55934  1.000 24.78346  ? 17  MET A CG   1 
ATOM   243  S SD   . MET A 1 17  ? -11.52488 -38.36288 13.24412  1.000 27.78140  ? 17  MET A SD   1 
ATOM   244  C CE   . MET A 1 17  ? -11.36640 -37.70963 11.58130  1.000 24.00373  ? 17  MET A CE   1 
ATOM   245  H H    . MET A 1 17  ? -9.89556  -41.91551 13.98314  1.000 27.80103  ? 17  MET A H    1 
ATOM   246  H HA   . MET A 1 17  ? -11.18550 -40.73922 11.93936  1.000 28.10931  ? 17  MET A HA   1 
ATOM   247  H HB2  . MET A 1 17  ? -8.52692  -40.34048 12.80739  1.000 30.99766  ? 17  MET A HB2  1 
ATOM   248  H HB3  . MET A 1 17  ? -9.23918  -39.47829 11.67834  1.000 30.99766  ? 17  MET A HB3  1 
ATOM   249  H HG2  . MET A 1 17  ? -9.86493  -39.43534 14.42107  1.000 29.72720  ? 17  MET A HG2  1 
ATOM   250  H HG3  . MET A 1 17  ? -9.25374  -38.23091 13.58369  1.000 29.72720  ? 17  MET A HG3  1 
ATOM   251  H HE1  . MET A 1 17  ? -11.01754 -38.40424 11.00103  1.000 28.79152  ? 17  MET A HE1  1 
ATOM   252  H HE2  . MET A 1 17  ? -12.23971 -37.42548 11.26906  1.000 28.79152  ? 17  MET A HE2  1 
ATOM   253  H HE3  . MET A 1 17  ? -10.75823 -36.95409 11.59545  1.000 28.79152  ? 17  MET A HE3  1 
ATOM   254  N N    . VAL A 1 18  ? -10.40932 -41.95335 9.96703   1.000 24.43476  ? 18  VAL A N    1 
ATOM   255  C CA   . VAL A 1 18  ? -9.97972  -42.70896 8.80205   1.000 23.97137  ? 18  VAL A CA   1 
ATOM   256  C C    . VAL A 1 18  ? -9.92356  -41.76357 7.60792   1.000 24.63574  ? 18  VAL A C    1 
ATOM   257  O O    . VAL A 1 18  ? -10.44002 -40.64568 7.64169   1.000 22.51454  ? 18  VAL A O    1 
ATOM   258  C CB   . VAL A 1 18  ? -10.90567 -43.90690 8.49743   1.000 25.42326  ? 18  VAL A CB   1 
ATOM   259  C CG1  . VAL A 1 18  ? -10.91080 -44.88895 9.65642   1.000 25.19934  ? 18  VAL A CG1  1 
ATOM   260  C CG2  . VAL A 1 18  ? -12.30993 -43.42965 8.17962   1.000 24.17883  ? 18  VAL A CG2  1 
ATOM   261  H H    . VAL A 1 18  ? -11.08940 -41.44984 9.81351   1.000 29.30876  ? 18  VAL A H    1 
ATOM   262  H HA   . VAL A 1 18  ? -9.08738  -43.05341 8.96327   1.000 28.75269  ? 18  VAL A HA   1 
ATOM   263  H HB   . VAL A 1 18  ? -10.56774 -44.37311 7.71682   1.000 30.49496  ? 18  VAL A HB   1 
ATOM   264  H HG11 . VAL A 1 18  ? -11.43877 -45.66469 9.41070   1.000 30.22625  ? 18  VAL A HG11 1 
ATOM   265  H HG12 . VAL A 1 18  ? -9.99830  -45.15687 9.84738   1.000 30.22625  ? 18  VAL A HG12 1 
ATOM   266  H HG13 . VAL A 1 18  ? -11.29854 -44.45775 10.43400  1.000 30.22625  ? 18  VAL A HG13 1 
ATOM   267  H HG21 . VAL A 1 18  ? -12.91168 -44.19038 8.18892   1.000 29.00164  ? 18  VAL A HG21 1 
ATOM   268  H HG22 . VAL A 1 18  ? -12.58310 -42.78359 8.84960   1.000 29.00164  ? 18  VAL A HG22 1 
ATOM   269  H HG23 . VAL A 1 18  ? -12.31210 -43.01689 7.30182   1.000 29.00164  ? 18  VAL A HG23 1 
ATOM   270  N N    . GLN A 1 19  ? -9.28381  -42.23680 6.54353   1.000 24.51324  ? 19  GLN A N    1 
ATOM   271  C CA   . GLN A 1 19  ? -9.21349  -41.52849 5.27491   1.000 26.88200  ? 19  GLN A CA   1 
ATOM   272  C C    . GLN A 1 19  ? -10.27796 -42.06612 4.32857   1.000 25.87280  ? 19  GLN A C    1 
ATOM   273  O O    . GLN A 1 19  ? -10.47395 -43.27978 4.22639   1.000 27.33919  ? 19  GLN A O    1 
ATOM   274  C CB   . GLN A 1 19  ? -7.82425  -41.69293 4.65257   1.000 27.96409  ? 19  GLN A CB   1 
ATOM   275  C CG   . GLN A 1 19  ? -7.67403  -41.14613 3.24305   1.000 29.01026  ? 19  GLN A CG   1 
ATOM   276  C CD   . GLN A 1 19  ? -6.36521  -41.56749 2.61137   1.000 30.61047  ? 19  GLN A CD   1 
ATOM   277  O OE1  . GLN A 1 19  ? -6.26303  -42.64622 2.02287   1.000 32.66692  ? 19  GLN A OE1  1 
ATOM   278  N NE2  . GLN A 1 19  ? -5.35172  -40.72355 2.73878   1.000 32.78352  ? 19  GLN A NE2  1 
ATOM   279  H H    . GLN A 1 19  ? -8.87004  -42.99065 6.53337   1.000 29.40294  ? 19  GLN A H    1 
ATOM   280  H HA   . GLN A 1 19  ? -9.37825  -40.58232 5.41103   1.000 32.24545  ? 19  GLN A HA   1 
ATOM   281  H HB2  . GLN A 1 19  ? -7.18175  -41.22979 5.21257   1.000 33.54395  ? 19  GLN A HB2  1 
ATOM   282  H HB3  . GLN A 1 19  ? -7.61421  -42.63935 4.61966   1.000 33.54395  ? 19  GLN A HB3  1 
ATOM   283  H HG2  . GLN A 1 19  ? -8.39877  -41.48040 2.69177   1.000 34.79936  ? 19  GLN A HG2  1 
ATOM   284  H HG3  . GLN A 1 19  ? -7.69908  -40.17689 3.27202   1.000 34.79936  ? 19  GLN A HG3  1 
ATOM   285  H HE21 . GLN A 1 19  ? -5.45945  -39.98305 3.16264   1.000 39.32727  ? 19  GLN A HE21 1 
ATOM   286  H HE22 . GLN A 1 19  ? -4.58618  -40.91628 2.39761   1.000 39.32727  ? 19  GLN A HE22 1 
ATOM   287  N N    . VAL A 1 20  ? -10.96150 -41.15971 3.63252   1.000 25.31517  ? 20  VAL A N    1 
ATOM   288  C CA   . VAL A 1 20  ? -11.99867 -41.52448 2.67409   1.000 24.19471  ? 20  VAL A CA   1 
ATOM   289  C C    . VAL A 1 20  ? -11.66277 -40.86876 1.34329   1.000 26.49914  ? 20  VAL A C    1 
ATOM   290  O O    . VAL A 1 20  ? -11.52060 -39.64181 1.26955   1.000 26.68371  ? 20  VAL A O    1 
ATOM   291  C CB   . VAL A 1 20  ? -13.40272 -41.10507 3.13941   1.000 25.33738  ? 20  VAL A CB   1 
ATOM   292  C CG1  . VAL A 1 20  ? -14.46099 -41.64534 2.17500   1.000 25.58024  ? 20  VAL A CG1  1 
ATOM   293  C CG2  . VAL A 1 20  ? -13.66302 -41.58059 4.57152   1.000 24.05224  ? 20  VAL A CG2  1 
ATOM   294  H H    . VAL A 1 20  ? -10.83863 -40.31128 3.70085   1.000 30.36525  ? 20  VAL A H    1 
ATOM   295  H HA   . VAL A 1 20  ? -11.99286 -42.48715 2.55523   1.000 29.02070  ? 20  VAL A HA   1 
ATOM   296  H HB   . VAL A 1 20  ? -13.46250 -40.13691 3.13907   1.000 30.39190  ? 20  VAL A HB   1 
ATOM   297  H HG11 . VAL A 1 20  ? -14.17623 -42.51279 1.84736   1.000 30.68334  ? 20  VAL A HG11 1 
ATOM   298  H HG12 . VAL A 1 20  ? -15.30420 -41.73048 2.64686   1.000 30.68334  ? 20  VAL A HG12 1 
ATOM   299  H HG13 . VAL A 1 20  ? -14.55770 -41.02723 1.43373   1.000 30.68334  ? 20  VAL A HG13 1 
ATOM   300  H HG21 . VAL A 1 20  ? -12.93998 -42.16594 4.84625   1.000 28.84974  ? 20  VAL A HG21 1 
ATOM   301  H HG22 . VAL A 1 20  ? -13.70487 -40.80896 5.15780   1.000 28.84974  ? 20  VAL A HG22 1 
ATOM   302  H HG23 . VAL A 1 20  ? -14.50528 -42.06110 4.59655   1.000 28.84974  ? 20  VAL A HG23 1 
ATOM   303  N N    . THR A 1 21  ? -11.53991 -41.68070 0.29756   1.000 26.81036  ? 21  THR A N    1 
ATOM   304  C CA   . THR A 1 21  ? -11.21841 -41.20945 -1.04194  1.000 27.66472  ? 21  THR A CA   1 
ATOM   305  C C    . THR A 1 21  ? -12.30221 -41.67917 -1.99910  1.000 27.86058  ? 21  THR A C    1 
ATOM   306  O O    . THR A 1 21  ? -12.68344 -42.85529 -1.98448  1.000 28.06574  ? 21  THR A O    1 
ATOM   307  C CB   . THR A 1 21  ? -9.84787  -41.72383 -1.49839  1.000 28.73790  ? 21  THR A CB   1 
ATOM   308  O OG1  . THR A 1 21  ? -8.84618  -41.32341 -0.55567  1.000 30.13395  ? 21  THR A OG1  1 
ATOM   309  C CG2  . THR A 1 21  ? -9.49115  -41.17215 -2.86876  1.000 31.60341  ? 21  THR A CG2  1 
ATOM   310  H H    . THR A 1 21  ? -11.64160 -42.53348 0.34254   1.000 32.15947  ? 21  THR A H    1 
ATOM   311  H HA   . THR A 1 21  ? -11.19345 -40.23981 -1.05059  1.000 33.18471  ? 21  THR A HA   1 
ATOM   312  H HB   . THR A 1 21  ? -9.87412  -42.69169 -1.55708  1.000 34.47252  ? 21  THR A HB   1 
ATOM   313  H HG1  . THR A 1 21  ? -9.00783  -41.66129 0.19620   1.000 36.14779  ? 21  THR A HG1  1 
ATOM   314  H HG21 . THR A 1 21  ? -8.57491  -41.40092 -3.09027  1.000 37.91113  ? 21  THR A HG21 1 
ATOM   315  H HG22 . THR A 1 21  ? -10.08075 -41.54760 -3.54130  1.000 37.91113  ? 21  THR A HG22 1 
ATOM   316  H HG23 . THR A 1 21  ? -9.58417  -40.20663 -2.87219  1.000 37.91113  ? 21  THR A HG23 1 
ATOM   317  N N    . CYS A 1 22  ? -12.80677 -40.75745 -2.81326  1.000 28.26968  ? 22  CYS A N    1 
ATOM   318  C CA   . CYS A 1 22  ? -13.71529 -41.08302 -3.90590  1.000 30.78558  ? 22  CYS A CA   1 
ATOM   319  C C    . CYS A 1 22  ? -13.24800 -40.32676 -5.14019  1.000 31.89533  ? 22  CYS A C    1 
ATOM   320  O O    . CYS A 1 22  ? -13.14665 -39.09561 -5.11597  1.000 32.42447  ? 22  CYS A O    1 
ATOM   321  C CB   . CYS A 1 22  ? -15.16198 -40.72909 -3.55229  1.000 29.56074  ? 22  CYS A CB   1 
ATOM   322  S SG   . CYS A 1 22  ? -16.35801 -41.13944 -4.82858  1.000 36.41865  ? 22  CYS A SG   1 
ATOM   323  H H    . CYS A 1 22  ? -12.63309 -39.91750 -2.75065  1.000 33.91066  ? 22  CYS A H    1 
ATOM   324  H HA   . CYS A 1 22  ? -13.68514 -42.03396 -4.09489  1.000 36.92974  ? 22  CYS A HA   1 
ATOM   325  H HB2  . CYS A 1 22  ? -15.41151 -41.21290 -2.74945  1.000 35.45993  ? 22  CYS A HB2  1 
ATOM   326  H HB3  . CYS A 1 22  ? -15.21704 -39.77361 -3.39444  1.000 35.45993  ? 22  CYS A HB3  1 
ATOM   327  H HG   . CYS A 1 22  ? -17.46297 -40.92787 -4.41108  1.000 43.68943  ? 22  CYS A HG   1 
ATOM   328  N N    . GLY A 1 23  ? -12.95057 -41.05765 -6.20553  1.000 32.97406  ? 23  GLY A N    1 
ATOM   329  C CA   . GLY A 1 23  ? -12.34885 -40.42948 -7.37000  1.000 32.87956  ? 23  GLY A CA   1 
ATOM   330  C C    . GLY A 1 23  ? -11.00064 -39.83150 -7.01302  1.000 29.49541  ? 23  GLY A C    1 
ATOM   331  O O    . GLY A 1 23  ? -10.08545 -40.52695 -6.55743  1.000 29.52678  ? 23  GLY A O    1 
ATOM   332  H H    . GLY A 1 23  ? -13.08448 -41.90401 -6.27866  1.000 39.55592  ? 23  GLY A H    1 
ATOM   333  H HA2  . GLY A 1 23  ? -12.22381 -41.08792 -8.07123  1.000 39.44252  ? 23  GLY A HA2  1 
ATOM   334  H HA3  . GLY A 1 23  ? -12.92741 -39.72381 -7.69893  1.000 39.44252  ? 23  GLY A HA3  1 
ATOM   335  N N    . THR A 1 24  ? -10.87000 -38.52256 -7.21159  1.000 32.32294  ? 24  THR A N    1 
ATOM   336  C CA   . THR A 1 24  ? -9.63564  -37.80039 -6.94308  1.000 35.83255  ? 24  THR A CA   1 
ATOM   337  C C    . THR A 1 24  ? -9.67999  -37.00985 -5.64159  1.000 37.61306  ? 24  THR A C    1 
ATOM   338  O O    . THR A 1 24  ? -8.68095  -36.37679 -5.28420  1.000 39.67890  ? 24  THR A O    1 
ATOM   339  C CB   . THR A 1 24  ? -9.32320  -36.84885 -8.10813  1.000 41.39325  ? 24  THR A CB   1 
ATOM   340  O OG1  . THR A 1 24  ? -8.04366  -36.24091 -7.90451  1.000 44.09534  ? 24  THR A OG1  1 
ATOM   341  C CG2  . THR A 1 24  ? -10.38650 -35.75630 -8.22059  1.000 43.37757  ? 24  THR A CG2  1 
ATOM   342  H H    . THR A 1 24  ? -11.50084 -38.01964 -7.50942  1.000 38.77457  ? 24  THR A H    1 
ATOM   343  H HA   . THR A 1 24  ? -8.91184  -38.44242 -6.87379  1.000 42.98611  ? 24  THR A HA   1 
ATOM   344  H HB   . THR A 1 24  ? -9.31633  -37.35303 -8.93678  1.000 49.65894  ? 24  THR A HB   1 
ATOM   345  H HG1  . THR A 1 24  ? -7.82224  -35.80240 -8.58588  1.000 52.90145  ? 24  THR A HG1  1 
ATOM   346  H HG21 . THR A 1 24  ? -10.30326 -35.29870 -9.07181  1.000 52.04013  ? 24  THR A HG21 1 
ATOM   347  H HG22 . THR A 1 24  ? -11.27197 -36.14750 -8.15875  1.000 52.04013  ? 24  THR A HG22 1 
ATOM   348  H HG23 . THR A 1 24  ? -10.27656 -35.11139 -7.50442  1.000 52.04013  ? 24  THR A HG23 1 
ATOM   349  N N    . THR A 1 25  ? -10.79832 -37.03854 -4.92194  1.000 35.02136  ? 25  THR A N    1 
ATOM   350  C CA   . THR A 1 25  ? -10.98540 -36.23092 -3.72251  1.000 31.93900  ? 25  THR A CA   1 
ATOM   351  C C    . THR A 1 25  ? -10.74652 -37.08225 -2.48240  1.000 29.71037  ? 25  THR A C    1 
ATOM   352  O O    . THR A 1 25  ? -11.30036 -38.17830 -2.36194  1.000 28.24887  ? 25  THR A O    1 
ATOM   353  C CB   . THR A 1 25  ? -12.39395 -35.63861 -3.68881  1.000 32.11038  ? 25  THR A CB   1 
ATOM   354  O OG1  . THR A 1 25  ? -12.75940 -35.20330 -5.00432  1.000 34.93052  ? 25  THR A OG1  1 
ATOM   355  C CG2  . THR A 1 25  ? -12.46057 -34.45844 -2.73590  1.000 35.00880  ? 25  THR A CG2  1 
ATOM   356  H H    . THR A 1 25  ? -11.47783 -37.52956 -5.11368  1.000 42.01268  ? 25  THR A H    1 
ATOM   357  H HA   . THR A 1 25  ? -10.34223 -35.50482 -3.71947  1.000 38.31385  ? 25  THR A HA   1 
ATOM   358  H HB   . THR A 1 25  ? -13.01908 -36.31330 -3.38074  1.000 38.51950  ? 25  THR A HB   1 
ATOM   359  H HG1  . THR A 1 25  ? -13.01479 -35.85886 -5.46327  1.000 41.90368  ? 25  THR A HG1  1 
ATOM   360  H HG21 . THR A 1 25  ? -11.60877 -33.99459 -2.72221  1.000 41.99760  ? 25  THR A HG21 1 
ATOM   361  H HG22 . THR A 1 25  ? -13.15120 -33.84006 -3.02144  1.000 41.99760  ? 25  THR A HG22 1 
ATOM   362  H HG23 . THR A 1 25  ? -12.66540 -34.76704 -1.83941  1.000 41.99760  ? 25  THR A HG23 1 
ATOM   363  N N    . THR A 1 26  ? -9.92521  -36.57459 -1.56382  1.000 29.73295  ? 26  THR A N    1 
ATOM   364  C CA   . THR A 1 26  ? -9.60444  -37.27158 -0.32536  1.000 27.78939  ? 26  THR A CA   1 
ATOM   365  C C    . THR A 1 26  ? -9.91363  -36.36620 0.85802   1.000 25.73133  ? 26  THR A C    1 
ATOM   366  O O    . THR A 1 26  ? -9.57928  -35.17728 0.84801   1.000 27.76353  ? 26  THR A O    1 
ATOM   367  C CB   . THR A 1 26  ? -8.13011  -37.70330 -0.29044  1.000 29.03215  ? 26  THR A CB   1 
ATOM   368  O OG1  . THR A 1 26  ? -7.87423  -38.62575 -1.35832  1.000 34.37615  ? 26  THR A OG1  1 
ATOM   369  C CG2  . THR A 1 26  ? -7.79391  -38.37579 1.02932   1.000 29.26073  ? 26  THR A CG2  1 
ATOM   370  H H    . THR A 1 26  ? -9.53500  -35.81198 -1.63972  1.000 35.66659  ? 26  THR A H    1 
ATOM   371  H HA   . THR A 1 26  ? -10.15157 -38.06887 -0.24858  1.000 33.33432  ? 26  THR A HA   1 
ATOM   372  H HB   . THR A 1 26  ? -7.56758  -36.91918 -0.38848  1.000 34.82563  ? 26  THR A HB   1 
ATOM   373  H HG1  . THR A 1 26  ? -8.44313  -39.24367 -1.34671  1.000 41.23842  ? 26  THR A HG1  1 
ATOM   374  H HG21 . THR A 1 26  ? -7.67075  -37.70668 1.72071   1.000 35.09992  ? 26  THR A HG21 1 
ATOM   375  H HG22 . THR A 1 26  ? -8.51395  -38.97053 1.29151   1.000 35.09992  ? 26  THR A HG22 1 
ATOM   376  H HG23 . THR A 1 26  ? -6.97675  -38.89082 0.94054   1.000 35.09992  ? 26  THR A HG23 1 
ATOM   377  N N    . LEU A 1 27  ? -10.55115 -36.93384 1.87661   1.000 25.04191  ? 27  LEU A N    1 
ATOM   378  C CA   . LEU A 1 27  ? -10.81925 -36.21214 3.11371   1.000 23.73150  ? 27  LEU A CA   1 
ATOM   379  C C    . LEU A 1 27  ? -10.91845 -37.23184 4.24264   1.000 22.98348  ? 27  LEU A C    1 
ATOM   380  O O    . LEU A 1 27  ? -10.52215 -38.39093 4.09014   1.000 23.92923  ? 27  LEU A O    1 
ATOM   381  C CB   . LEU A 1 27  ? -12.07062 -35.34023 2.95910   1.000 22.93954  ? 27  LEU A CB   1 
ATOM   382  C CG   . LEU A 1 27  ? -13.28006 -35.94116 2.24390   1.000 24.68682  ? 27  LEU A CG   1 
ATOM   383  C CD1  . LEU A 1 27  ? -13.85349 -37.12621 3.00613   1.000 25.54767  ? 27  LEU A CD1  1 
ATOM   384  C CD2  . LEU A 1 27  ? -14.34267 -34.87249 2.03645   1.000 25.20064  ? 27  LEU A CD2  1 
ATOM   385  H H    . LEU A 1 27  ? -10.84080 -37.74360 1.87468   1.000 30.03734  ? 27  LEU A H    1 
ATOM   386  H HA   . LEU A 1 27  ? -10.07533 -35.62370 3.31675   1.000 28.46485  ? 27  LEU A HA   1 
ATOM   387  H HB2  . LEU A 1 27  ? -12.36805 -35.09168 3.84829   1.000 27.51450  ? 27  LEU A HB2  1 
ATOM   388  H HB3  . LEU A 1 27  ? -11.81755 -34.54772 2.46032   1.000 27.51450  ? 27  LEU A HB3  1 
ATOM   389  H HG   . LEU A 1 27  ? -12.99476 -36.27273 1.37812   1.000 29.61123  ? 27  LEU A HG   1 
ATOM   390  H HD11 . LEU A 1 27  ? -13.31666 -37.91203 2.81853   1.000 30.64425  ? 27  LEU A HD11 1 
ATOM   391  H HD12 . LEU A 1 27  ? -13.83291 -36.93061 3.95598   1.000 30.64425  ? 27  LEU A HD12 1 
ATOM   392  H HD13 . LEU A 1 27  ? -14.76802 -37.27402 2.71858   1.000 30.64425  ? 27  LEU A HD13 1 
ATOM   393  H HD21 . LEU A 1 27  ? -14.67332 -34.58381 2.90146   1.000 30.22781  ? 27  LEU A HD21 1 
ATOM   394  H HD22 . LEU A 1 27  ? -13.94789 -34.12175 1.56589   1.000 30.22781  ? 27  LEU A HD22 1 
ATOM   395  H HD23 . LEU A 1 27  ? -15.06857 -35.24637 1.51282   1.000 30.22781  ? 27  LEU A HD23 1 
ATOM   396  N N    . ASN A 1 28  ? -11.43980 -36.79799 5.38622   1.000 24.77860  ? 28  ASN A N    1 
ATOM   397  C CA   . ASN A 1 28  ? -11.47839 -37.62161 6.58371   1.000 22.38656  ? 28  ASN A CA   1 
ATOM   398  C C    . ASN A 1 28  ? -12.88352 -38.14218 6.83397   1.000 23.52917  ? 28  ASN A C    1 
ATOM   399  O O    . ASN A 1 28  ? -13.87755 -37.52546 6.43966   1.000 22.46849  ? 28  ASN A O    1 
ATOM   400  C CB   . ASN A 1 28  ? -11.01876 -36.83471 7.81414   1.000 24.27573  ? 28  ASN A CB   1 
ATOM   401  C CG   . ASN A 1 28  ? -9.70837  -36.11825 7.58920   1.000 25.00233  ? 28  ASN A CG   1 
ATOM   402  O OD1  . ASN A 1 28  ? -8.64142  -36.72838 7.61972   1.000 26.19118  ? 28  ASN A OD1  1 
ATOM   403  N ND2  . ASN A 1 28  ? -9.78240  -34.81094 7.36431   1.000 23.99735  ? 28  ASN A ND2  1 
ATOM   404  H H    . ASN A 1 28  ? -11.78248 -36.01636 5.49222   1.000 29.72136  ? 28  ASN A H    1 
ATOM   405  H HA   . ASN A 1 28  ? -10.88288 -38.37647 6.45545   1.000 26.85092  ? 28  ASN A HA   1 
ATOM   406  H HB2  . ASN A 1 28  ? -11.69051 -36.17051 8.03431   1.000 29.11793  ? 28  ASN A HB2  1 
ATOM   407  H HB3  . ASN A 1 28  ? -10.90247 -37.44778 8.55679   1.000 29.11793  ? 28  ASN A HB3  1 
ATOM   408  H HD21 . ASN A 1 28  ? -9.06477  -34.35639 7.23016   1.000 28.78386  ? 28  ASN A HD21 1 
ATOM   409  H HD22 . ASN A 1 28  ? -10.54794 -34.41926 7.35287   1.000 28.78386  ? 28  ASN A HD22 1 
ATOM   410  N N    . GLY A 1 29  ? -12.94805 -39.29261 7.50460   1.000 22.02151  ? 29  GLY A N    1 
ATOM   411  C CA   . GLY A 1 29  ? -14.20177 -39.83281 7.96790   1.000 21.63797  ? 29  GLY A CA   1 
ATOM   412  C C    . GLY A 1 29  ? -14.09168 -40.22893 9.42746   1.000 21.14594  ? 29  GLY A C    1 
ATOM   413  O O    . GLY A 1 29  ? -12.99929 -40.39467 9.97057   1.000 22.74296  ? 29  GLY A O    1 
ATOM   414  H H    . GLY A 1 29  ? -12.26552 -39.77750 7.70117   1.000 26.41285  ? 29  GLY A H    1 
ATOM   415  H HA2  . GLY A 1 29  ? -14.90238 -39.16859 7.87386   1.000 25.95261  ? 29  GLY A HA2  1 
ATOM   416  H HA3  . GLY A 1 29  ? -14.43690 -40.61589 7.44597   1.000 25.95261  ? 29  GLY A HA3  1 
ATOM   417  N N    . LEU A 1 30  ? -15.25047 -40.37108 10.05888  1.000 21.12379  ? 30  LEU A N    1 
ATOM   418  C CA   . LEU A 1 30  ? -15.34843 -40.74719 11.46639  1.000 22.67106  ? 30  LEU A CA   1 
ATOM   419  C C    . LEU A 1 30  ? -15.91802 -42.15808 11.55735  1.000 22.60270  ? 30  LEU A C    1 
ATOM   420  O O    . LEU A 1 30  ? -17.05927 -42.40057 11.15068  1.000 24.00784  ? 30  LEU A O    1 
ATOM   421  C CB   . LEU A 1 30  ? -16.21934 -39.75402 12.23442  1.000 22.83640  ? 30  LEU A CB   1 
ATOM   422  C CG   . LEU A 1 30  ? -16.37323 -39.97130 13.74410  1.000 22.92929  ? 30  LEU A CG   1 
ATOM   423  C CD1  . LEU A 1 30  ? -15.09147 -39.62762 14.48227  1.000 26.27872  ? 30  LEU A CD1  1 
ATOM   424  C CD2  . LEU A 1 30  ? -17.53496 -39.14688 14.26351  1.000 21.74637  ? 30  LEU A CD2  1 
ATOM   425  H H    . LEU A 1 30  ? -16.01517 -40.25200 9.68384   1.000 25.33560  ? 30  LEU A H    1 
ATOM   426  H HA   . LEU A 1 30  ? -14.46568 -40.74988 11.86844  1.000 27.19232  ? 30  LEU A HA   1 
ATOM   427  H HB2  . LEU A 1 30  ? -15.83774 -38.87027 12.11500  1.000 27.39072  ? 30  LEU A HB2  1 
ATOM   428  H HB3  . LEU A 1 30  ? -17.11094 -39.78462 11.85362  1.000 27.39072  ? 30  LEU A HB3  1 
ATOM   429  H HG   . LEU A 1 30  ? -16.55721 -40.90831 13.91459  1.000 27.50219  ? 30  LEU A HG   1 
ATOM   430  H HD11 . LEU A 1 30  ? -15.17572 -39.90575 15.40772  1.000 31.52151  ? 30  LEU A HD11 1 
ATOM   431  H HD12 . LEU A 1 30  ? -14.35101 -40.09330 14.06302  1.000 31.52151  ? 30  LEU A HD12 1 
ATOM   432  H HD13 . LEU A 1 30  ? -14.94798 -38.66937 14.43663  1.000 31.52151  ? 30  LEU A HD13 1 
ATOM   433  H HD21 . LEU A 1 30  ? -17.35938 -38.89903 15.18472  1.000 26.08268  ? 30  LEU A HD21 1 
ATOM   434  H HD22 . LEU A 1 30  ? -17.62545 -38.34990 13.71803  1.000 26.08268  ? 30  LEU A HD22 1 
ATOM   435  H HD23 . LEU A 1 30  ? -18.34594 -39.67659 14.21230  1.000 26.08268  ? 30  LEU A HD23 1 
ATOM   436  N N    . TRP A 1 31  ? -15.12456 -43.07755 12.09327  1.000 23.19898  ? 31  TRP A N    1 
ATOM   437  C CA   . TRP A 1 31  ? -15.43851 -44.50643 12.09157  1.000 23.00940  ? 31  TRP A CA   1 
ATOM   438  C C    . TRP A 1 31  ? -15.93371 -44.89102 13.48230  1.000 25.58162  ? 31  TRP A C    1 
ATOM   439  O O    . TRP A 1 31  ? -15.14551 -45.00796 14.42143  1.000 22.29407  ? 31  TRP A O    1 
ATOM   440  C CB   . TRP A 1 31  ? -14.20188 -45.30339 11.68684  1.000 25.77025  ? 31  TRP A CB   1 
ATOM   441  C CG   . TRP A 1 31  ? -14.36809 -46.79618 11.59078  1.000 25.43669  ? 31  TRP A CG   1 
ATOM   442  C CD1  . TRP A 1 31  ? -15.52823 -47.49722 11.41864  1.000 25.89822  ? 31  TRP A CD1  1 
ATOM   443  C CD2  . TRP A 1 31  ? -13.31791 -47.76808 11.66046  1.000 26.27749  ? 31  TRP A CD2  1 
ATOM   444  N NE1  . TRP A 1 31  ? -15.26092 -48.85095 11.37855  1.000 25.18286  ? 31  TRP A NE1  1 
ATOM   445  C CE2  . TRP A 1 31  ? -13.91125 -49.04003 11.52370  1.000 26.83999  ? 31  TRP A CE2  1 
ATOM   446  C CE3  . TRP A 1 31  ? -11.93291 -47.68538 11.82805  1.000 27.14434  ? 31  TRP A CE3  1 
ATOM   447  C CZ2  . TRP A 1 31  ? -13.16434 -50.21726 11.54898  1.000 26.77881  ? 31  TRP A CZ2  1 
ATOM   448  C CZ3  . TRP A 1 31  ? -11.19451 -48.85463 11.85068  1.000 30.72041  ? 31  TRP A CZ3  1 
ATOM   449  C CH2  . TRP A 1 31  ? -11.81089 -50.10325 11.71546  1.000 27.37749  ? 31  TRP A CH2  1 
ATOM   450  H H    . TRP A 1 31  ? -14.37608 -42.89553 12.47568  1.000 27.82582  ? 31  TRP A H    1 
ATOM   451  H HA   . TRP A 1 31  ? -16.15369 -44.68965 11.46241  1.000 27.59833  ? 31  TRP A HA   1 
ATOM   452  H HB2  . TRP A 1 31  ? -13.91522 -44.99241 10.81390  1.000 30.91134  ? 31  TRP A HB2  1 
ATOM   453  H HB3  . TRP A 1 31  ? -13.50742 -45.13622 12.34309  1.000 30.91134  ? 31  TRP A HB3  1 
ATOM   454  H HD1  . TRP A 1 31  ? -16.37377 -47.11804 11.34004  1.000 31.06491  ? 31  TRP A HD1  1 
ATOM   455  H HE1  . TRP A 1 31  ? -15.84558 -49.47371 11.27881  1.000 30.20647  ? 31  TRP A HE1  1 
ATOM   456  H HE3  . TRP A 1 31  ? -11.51562 -46.85965 11.92258  1.000 32.56025  ? 31  TRP A HE3  1 
ATOM   457  H HZ2  . TRP A 1 31  ? -13.57073 -51.04860 11.45618  1.000 32.12162  ? 31  TRP A HZ2  1 
ATOM   458  H HZ3  . TRP A 1 31  ? -10.27177 -48.81004 11.95770  1.000 36.85154  ? 31  TRP A HZ3  1 
ATOM   459  H HH2  . TRP A 1 31  ? -11.28925 -50.87282 11.73924  1.000 32.84004  ? 31  TRP A HH2  1 
ATOM   460  N N    . LEU A 1 32  ? -17.24756 -45.07836 13.60840  1.000 23.59096  ? 32  LEU A N    1 
ATOM   461  C CA   . LEU A 1 32  ? -17.87554 -45.48068 14.85965  1.000 28.09215  ? 32  LEU A CA   1 
ATOM   462  C C    . LEU A 1 32  ? -18.71688 -46.71495 14.58482  1.000 25.88670  ? 32  LEU A C    1 
ATOM   463  O O    . LEU A 1 32  ? -19.53577 -46.71731 13.65911  1.000 23.71228  ? 32  LEU A O    1 
ATOM   464  C CB   . LEU A 1 32  ? -18.74446 -44.35848 15.43891  1.000 27.64422  ? 32  LEU A CB   1 
ATOM   465  C CG   . LEU A 1 32  ? -18.05417 -43.01055 15.65087  1.000 26.57559  ? 32  LEU A CG   1 
ATOM   466  C CD1  . LEU A 1 32  ? -19.08623 -41.90539 15.77776  1.000 27.12740  ? 32  LEU A CD1  1 
ATOM   467  C CD2  . LEU A 1 32  ? -17.15275 -43.04027 16.87859  1.000 25.27430  ? 32  LEU A CD2  1 
ATOM   468  H H    . LEU A 1 32  ? -17.80790 -44.97497 12.96425  1.000 28.29620  ? 32  LEU A H    1 
ATOM   469  H HA   . LEU A 1 32  ? -17.19830 -45.69738 15.51941  1.000 33.69762  ? 32  LEU A HA   1 
ATOM   470  H HB2  . LEU A 1 32  ? -19.48632 -44.20793 14.83239  1.000 33.16011  ? 32  LEU A HB2  1 
ATOM   471  H HB3  . LEU A 1 32  ? -19.07602 -44.64928 16.30286  1.000 33.16011  ? 32  LEU A HB3  1 
ATOM   472  H HG   . LEU A 1 32  ? -17.49476 -42.82389 14.88072  1.000 31.87775  ? 32  LEU A HG   1 
ATOM   473  H HD11 . LEU A 1 32  ? -19.56473 -41.82222 14.93811  1.000 32.53993  ? 32  LEU A HD11 1 
ATOM   474  H HD12 . LEU A 1 32  ? -19.70478 -42.13120 16.49002  1.000 32.53993  ? 32  LEU A HD12 1 
ATOM   475  H HD13 . LEU A 1 32  ? -18.63354 -41.07276 15.98439  1.000 32.53993  ? 32  LEU A HD13 1 
ATOM   476  H HD21 . LEU A 1 32  ? -16.65432 -43.87240 16.88434  1.000 30.31620  ? 32  LEU A HD21 1 
ATOM   477  H HD22 . LEU A 1 32  ? -16.54100 -42.28852 16.83948  1.000 30.31620  ? 32  LEU A HD22 1 
ATOM   478  H HD23 . LEU A 1 32  ? -17.70235 -42.97838 17.67547  1.000 30.31620  ? 32  LEU A HD23 1 
ATOM   479  N N    . ASP A 1 33  ? -18.51911 -47.75964 15.38166  1.000 26.48903  ? 33  ASP A N    1 
ATOM   480  C CA   . ASP A 1 33  ? -19.18319 -49.04300 15.13240  1.000 24.43750  ? 33  ASP A CA   1 
ATOM   481  C C    . ASP A 1 33  ? -18.83002 -49.45022 13.70463  1.000 26.60394  ? 33  ASP A C    1 
ATOM   482  O O    . ASP A 1 33  ? -17.65824 -49.33649 13.30059  1.000 25.16120  ? 33  ASP A O    1 
ATOM   483  C CB   . ASP A 1 33  ? -20.67347 -48.91542 15.40777  1.000 25.77615  ? 33  ASP A CB   1 
ATOM   484  C CG   . ASP A 1 33  ? -20.97641 -48.57579 16.85069  1.000 33.95544  ? 33  ASP A CG   1 
ATOM   485  O OD1  . ASP A 1 33  ? -20.21271 -49.01229 17.73719  1.000 34.48408  ? 33  ASP A OD1  1 
ATOM   486  O OD2  . ASP A 1 33  ? -21.97781 -47.87031 17.09821  1.000 35.11373  ? 33  ASP A OD2  1 
ATOM   487  H H    . ASP A 1 33  ? -18.00672 -47.75346 16.07232  1.000 31.77388  ? 33  ASP A H    1 
ATOM   488  H HA   . ASP A 1 33  ? -18.81767 -49.70577 15.73904  1.000 29.31205  ? 33  ASP A HA   1 
ATOM   489  H HB2  . ASP A 1 33  ? -21.03836 -48.21000 14.85086  1.000 30.91842  ? 33  ASP A HB2  1 
ATOM   490  H HB3  . ASP A 1 33  ? -21.10621 -49.75859 15.20112  1.000 30.91842  ? 33  ASP A HB3  1 
ATOM   491  N N    . ASP A 1 34  ? -19.78827 -49.90413 12.89836  1.000 24.11122  ? 34  ASP A N    1 
ATOM   492  C CA   . ASP A 1 34  ? -19.52816 -50.31982 11.52848  1.000 25.16905  ? 34  ASP A CA   1 
ATOM   493  C C    . ASP A 1 34  ? -19.95492 -49.26795 10.51154  1.000 26.64480  ? 34  ASP A C    1 
ATOM   494  O O    . ASP A 1 34  ? -20.38859 -49.61270 9.40633   1.000 27.25996  ? 34  ASP A O    1 
ATOM   495  C CB   . ASP A 1 34  ? -20.22199 -51.65251 11.23911  1.000 24.02812  ? 34  ASP A CB   1 
ATOM   496  C CG   . ASP A 1 34  ? -21.73646 -51.56980 11.34573  1.000 26.59081  ? 34  ASP A CG   1 
ATOM   497  O OD1  . ASP A 1 34  ? -22.26659 -50.49650 11.69683  1.000 26.13519  ? 34  ASP A OD1  1 
ATOM   498  O OD2  . ASP A 1 34  ? -22.40186 -52.59074 11.07799  1.000 28.08522  ? 34  ASP A OD2  1 
ATOM   499  H H    . ASP A 1 34  ? -20.61283 -49.98065 13.13042  1.000 28.92051  ? 34  ASP A H    1 
ATOM   500  H HA   . ASP A 1 34  ? -18.57251 -50.45135 11.42682  1.000 30.18990  ? 34  ASP A HA   1 
ATOM   501  H HB2  . ASP A 1 34  ? -20.00080 -51.93365 10.33748  1.000 28.82080  ? 34  ASP A HB2  1 
ATOM   502  H HB3  . ASP A 1 34  ? -19.91311 -52.31380 11.87800  1.000 28.82080  ? 34  ASP A HB3  1 
ATOM   503  N N    . VAL A 1 35  ? -19.82518 -47.98731 10.85117  1.000 25.59921  ? 35  VAL A N    1 
ATOM   504  C CA   . VAL A 1 35  ? -20.25638 -46.90354 9.97806   1.000 24.56179  ? 35  VAL A CA   1 
ATOM   505  C C    . VAL A 1 35  ? -19.17286 -45.83531 9.94811   1.000 25.73105  ? 35  VAL A C    1 
ATOM   506  O O    . VAL A 1 35  ? -18.60424 -45.47877 10.98711  1.000 24.02724  ? 35  VAL A O    1 
ATOM   507  C CB   . VAL A 1 35  ? -21.60462 -46.30797 10.43683  1.000 24.66477  ? 35  VAL A CB   1 
ATOM   508  C CG1  . VAL A 1 35  ? -21.99369 -45.13716 9.55085   1.000 27.35977  ? 35  VAL A CG1  1 
ATOM   509  C CG2  . VAL A 1 35  ? -22.69513 -47.38157 10.43048  1.000 24.83713  ? 35  VAL A CG2  1 
ATOM   510  H H    . VAL A 1 35  ? -19.48485 -47.71929 11.59410  1.000 30.70610  ? 35  VAL A H    1 
ATOM   511  H HA   . VAL A 1 35  ? -20.36486 -47.24600 9.07703   1.000 29.46120  ? 35  VAL A HA   1 
ATOM   512  H HB   . VAL A 1 35  ? -21.51303 -45.98089 11.34542  1.000 29.58477  ? 35  VAL A HB   1 
ATOM   513  H HG11 . VAL A 1 35  ? -22.90599 -44.87726 9.75352   1.000 32.81877  ? 35  VAL A HG11 1 
ATOM   514  H HG12 . VAL A 1 35  ? -21.39231 -44.39617 9.72455   1.000 32.81877  ? 35  VAL A HG12 1 
ATOM   515  H HG13 . VAL A 1 35  ? -21.92546 -45.40778 8.62187   1.000 32.81877  ? 35  VAL A HG13 1 
ATOM   516  H HG21 . VAL A 1 35  ? -23.54966 -46.96486 10.62291  1.000 29.79160  ? 35  VAL A HG21 1 
ATOM   517  H HG22 . VAL A 1 35  ? -22.72084 -47.80042 9.55595   1.000 29.79160  ? 35  VAL A HG22 1 
ATOM   518  H HG23 . VAL A 1 35  ? -22.49001 -48.04408 11.10864  1.000 29.79160  ? 35  VAL A HG23 1 
ATOM   519  N N    . VAL A 1 36  ? -18.88208 -45.33295 8.75283   1.000 21.01537  ? 36  VAL A N    1 
ATOM   520  C CA   . VAL A 1 36  ? -17.97023 -44.21213 8.56058   1.000 22.52120  ? 36  VAL A CA   1 
ATOM   521  C C    . VAL A 1 36  ? -18.79015 -43.00857 8.12207   1.000 23.32753  ? 36  VAL A C    1 
ATOM   522  O O    . VAL A 1 36  ? -19.58403 -43.09922 7.17553   1.000 22.95599  ? 36  VAL A O    1 
ATOM   523  C CB   . VAL A 1 36  ? -16.87361 -44.53752 7.53335   1.000 23.75794  ? 36  VAL A CB   1 
ATOM   524  C CG1  . VAL A 1 36  ? -15.94674 -43.34703 7.35866   1.000 22.18520  ? 36  VAL A CG1  1 
ATOM   525  C CG2  . VAL A 1 36  ? -16.08576 -45.76749 7.97248   1.000 22.45602  ? 36  VAL A CG2  1 
ATOM   526  H H    . VAL A 1 36  ? -19.21079 -45.63413 8.01741   1.000 25.20549  ? 36  VAL A H    1 
ATOM   527  H HA   . VAL A 1 36  ? -17.53761 -44.00268 9.40311   1.000 27.01248  ? 36  VAL A HA   1 
ATOM   528  H HB   . VAL A 1 36  ? -17.28722 -44.73035 6.67741   1.000 28.49657  ? 36  VAL A HB   1 
ATOM   529  H HG11 . VAL A 1 36  ? -15.65801 -43.04069 8.23256   1.000 26.60929  ? 36  VAL A HG11 1 
ATOM   530  H HG12 . VAL A 1 36  ? -15.17831 -43.61950 6.83314   1.000 26.60929  ? 36  VAL A HG12 1 
ATOM   531  H HG13 . VAL A 1 36  ? -16.42575 -42.63830 6.90133   1.000 26.60929  ? 36  VAL A HG13 1 
ATOM   532  H HG21 . VAL A 1 36  ? -15.23103 -45.77533 7.51392   1.000 26.93427  ? 36  VAL A HG21 1 
ATOM   533  H HG22 . VAL A 1 36  ? -15.94624 -45.72732 8.93155   1.000 26.93427  ? 36  VAL A HG22 1 
ATOM   534  H HG23 . VAL A 1 36  ? -16.59064 -46.56381 7.74472   1.000 26.93427  ? 36  VAL A HG23 1 
ATOM   535  N N    . TYR A 1 37  ? -18.60902 -41.88746 8.81355   1.000 24.80977  ? 37  TYR A N    1 
ATOM   536  C CA   . TYR A 1 37  ? -19.28517 -40.63807 8.49141   1.000 22.09479  ? 37  TYR A CA   1 
ATOM   537  C C    . TYR A 1 37  ? -18.29823 -39.68780 7.83567   1.000 24.28206  ? 37  TYR A C    1 
ATOM   538  O O    . TYR A 1 37  ? -17.17027 -39.53705 8.31513   1.000 23.78989  ? 37  TYR A O    1 
ATOM   539  C CB   . TYR A 1 37  ? -19.86783 -39.98875 9.74795   1.000 22.70920  ? 37  TYR A CB   1 
ATOM   540  C CG   . TYR A 1 37  ? -20.78469 -40.89149 10.53534  1.000 22.37683  ? 37  TYR A CG   1 
ATOM   541  C CD1  . TYR A 1 37  ? -20.27445 -41.83428 11.41496  1.000 24.10619  ? 37  TYR A CD1  1 
ATOM   542  C CD2  . TYR A 1 37  ? -22.16207 -40.79770 10.40248  1.000 24.03027  ? 37  TYR A CD2  1 
ATOM   543  C CE1  . TYR A 1 37  ? -21.11179 -42.66098 12.13503  1.000 26.41463  ? 37  TYR A CE1  1 
ATOM   544  C CE2  . TYR A 1 37  ? -23.00807 -41.62030 11.11922  1.000 26.31737  ? 37  TYR A CE2  1 
ATOM   545  C CZ   . TYR A 1 37  ? -22.47836 -42.54899 11.98446  1.000 28.02776  ? 37  TYR A CZ   1 
ATOM   546  O OH   . TYR A 1 37  ? -23.31827 -43.37199 12.70178  1.000 27.29881  ? 37  TYR A OH   1 
ATOM   547  H H    . TYR A 1 37  ? -18.08436 -41.82575 9.49218   1.000 29.75877  ? 37  TYR A H    1 
ATOM   548  H HA   . TYR A 1 37  ? -20.00914 -40.81571 7.87077   1.000 26.50079  ? 37  TYR A HA   1 
ATOM   549  H HB2  . TYR A 1 37  ? -19.13746 -39.72880 10.33094  1.000 27.23808  ? 37  TYR A HB2  1 
ATOM   550  H HB3  . TYR A 1 37  ? -20.37769 -39.20629 9.48583   1.000 27.23808  ? 37  TYR A HB3  1 
ATOM   551  H HD1  . TYR A 1 37  ? -19.35366 -41.91042 11.52107  1.000 28.91448  ? 37  TYR A HD1  1 
ATOM   552  H HD2  . TYR A 1 37  ? -22.52252 -40.16894 9.81970   1.000 28.82336  ? 37  TYR A HD2  1 
ATOM   553  H HE1  . TYR A 1 37  ? -20.75646 -43.29110 12.71948  1.000 31.68460  ? 37  TYR A HE1  1 
ATOM   554  H HE2  . TYR A 1 37  ? -23.92960 -41.54699 11.01768  1.000 31.56789  ? 37  TYR A HE2  1 
ATOM   555  H HH   . TYR A 1 37  ? -22.86802 -43.91906 13.15299  1.000 32.74562  ? 37  TYR A HH   1 
ATOM   556  N N    . CYS A 1 38  ? -18.71597 -39.04922 6.74609   1.000 24.06317  ? 38  CYS A N    1 
ATOM   557  C CA   . CYS A 1 38  ? -17.85362 -38.10459 6.05275   1.000 22.21071  ? 38  CYS A CA   1 
ATOM   558  C C    . CYS A 1 38  ? -18.72144 -37.12148 5.28382   1.000 23.51856  ? 38  CYS A C    1 
ATOM   559  O O    . CYS A 1 38  ? -19.87983 -37.42352 4.96614   1.000 25.38951  ? 38  CYS A O    1 
ATOM   560  C CB   . CYS A 1 38  ? -16.88173 -38.82529 5.10111   1.000 23.96784  ? 38  CYS A CB   1 
ATOM   561  S SG   . CYS A 1 38  ? -17.63929 -39.48319 3.59196   1.000 27.06220  ? 38  CYS A SG   1 
ATOM   562  H H    . CYS A 1 38  ? -19.49339 -39.14769 6.39181   1.000 28.86285  ? 38  CYS A H    1 
ATOM   563  H HA   . CYS A 1 38  ? -17.33546 -37.60679 6.70437   1.000 26.63990  ? 38  CYS A HA   1 
ATOM   564  H HB2  . CYS A 1 38  ? -16.19321 -38.19740 4.83168   1.000 28.74846  ? 38  CYS A HB2  1 
ATOM   565  H HB3  . CYS A 1 38  ? -16.48304 -39.57118 5.57607   1.000 28.74846  ? 38  CYS A HB3  1 
ATOM   566  H HG   . CYS A 1 38  ? -18.26543 -40.46925 3.86699   1.000 32.46169  ? 38  CYS A HG   1 
ATOM   567  N N    . PRO A 1 39  ? -18.19316 -35.94059 4.96430   1.000 22.12120  ? 39  PRO A N    1 
ATOM   568  C CA   . PRO A 1 39  ? -18.94708 -34.99627 4.13281   1.000 23.82731  ? 39  PRO A CA   1 
ATOM   569  C C    . PRO A 1 39  ? -19.26200 -35.58867 2.76955   1.000 23.89716  ? 39  PRO A C    1 
ATOM   570  O O    . PRO A 1 39  ? -18.45950 -36.32130 2.18753   1.000 24.40327  ? 39  PRO A O    1 
ATOM   571  C CB   . PRO A 1 39  ? -18.00477 -33.79126 4.01795   1.000 22.84415  ? 39  PRO A CB   1 
ATOM   572  C CG   . PRO A 1 39  ? -17.08743 -33.91126 5.18146   1.000 22.68824  ? 39  PRO A CG   1 
ATOM   573  C CD   . PRO A 1 39  ? -16.90882 -35.37647 5.41545   1.000 20.47315  ? 39  PRO A CD   1 
ATOM   574  H HA   . PRO A 1 39  ? -19.76937 -34.73093 4.57364   1.000 28.57982  ? 39  PRO A HA   1 
ATOM   575  H HB2  . PRO A 1 39  ? -17.51381 -33.83402 3.18247   1.000 27.40003  ? 39  PRO A HB2  1 
ATOM   576  H HB3  . PRO A 1 39  ? -18.51494 -32.96739 4.06117   1.000 27.40003  ? 39  PRO A HB3  1 
ATOM   577  H HG2  . PRO A 1 39  ? -16.23839 -33.49122 4.97265   1.000 27.21294  ? 39  PRO A HG2  1 
ATOM   578  H HG3  . PRO A 1 39  ? -17.48606 -33.48614 5.95687   1.000 27.21294  ? 39  PRO A HG3  1 
ATOM   579  H HD2  . PRO A 1 39  ? -16.17287 -35.72463 4.88813   1.000 24.55483  ? 39  PRO A HD2  1 
ATOM   580  H HD3  . PRO A 1 39  ? -16.75995 -35.56181 6.35587   1.000 24.55483  ? 39  PRO A HD3  1 
ATOM   581  N N    . ARG A 1 40  ? -20.44497 -35.25718 2.25133   1.000 24.05849  ? 40  ARG A N    1 
ATOM   582  C CA   . ARG A 1 40  ? -20.86619 -35.84786 0.99033   1.000 24.79676  ? 40  ARG A CA   1 
ATOM   583  C C    . ARG A 1 40  ? -20.12750 -35.26241 -0.20262  1.000 25.31469  ? 40  ARG A C    1 
ATOM   584  O O    . ARG A 1 40  ? -20.11061 -35.89332 -1.26150  1.000 26.66730  ? 40  ARG A O    1 
ATOM   585  C CB   . ARG A 1 40  ? -22.37608 -35.68784 0.79731   1.000 25.65902  ? 40  ARG A CB   1 
ATOM   586  C CG   . ARG A 1 40  ? -22.87534 -34.25354 0.78125   1.000 23.86564  ? 40  ARG A CG   1 
ATOM   587  C CD   . ARG A 1 40  ? -24.37629 -34.19733 0.51754   1.000 23.96333  ? 40  ARG A CD   1 
ATOM   588  N NE   . ARG A 1 40  ? -24.87305 -32.82661 0.48877   1.000 24.46782  ? 40  ARG A NE   1 
ATOM   589  C CZ   . ARG A 1 40  ? -26.11807 -32.48527 0.18569   1.000 27.29850  ? 40  ARG A CZ   1 
ATOM   590  N NH1  . ARG A 1 40  ? -27.03018 -33.39434 -0.12088  1.000 24.92380  ? 40  ARG A NH1  1 
ATOM   591  N NH2  . ARG A 1 40  ? -26.45488 -31.19996 0.18286   1.000 27.14695  ? 40  ARG A NH2  1 
ATOM   592  H H    . ARG A 1 40  ? -21.00468 -34.70722 2.60327   1.000 28.85724  ? 40  ARG A H    1 
ATOM   593  H HA   . ARG A 1 40  ? -20.67341 -36.79793 1.02333   1.000 29.74316  ? 40  ARG A HA   1 
ATOM   594  H HB2  . ARG A 1 40  ? -22.62104 -36.09006 -0.05069  1.000 30.77788  ? 40  ARG A HB2  1 
ATOM   595  H HB3  . ARG A 1 40  ? -22.82811 -36.14450 1.52398   1.000 30.77788  ? 40  ARG A HB3  1 
ATOM   596  H HG2  . ARG A 1 40  ? -22.69961 -33.84094 1.64135   1.000 28.62581  ? 40  ARG A HG2  1 
ATOM   597  H HG3  . ARG A 1 40  ? -22.42208 -33.76184 0.07862   1.000 28.62581  ? 40  ARG A HG3  1 
ATOM   598  H HD2  . ARG A 1 40  ? -24.56530 -34.60651 -0.34139  1.000 28.74304  ? 40  ARG A HD2  1 
ATOM   599  H HD3  . ARG A 1 40  ? -24.84250 -34.67416 1.22194   1.000 28.74304  ? 40  ARG A HD3  1 
ATOM   600  H HE   . ARG A 1 40  ? -24.32064 -32.19632 0.68161   1.000 29.34843  ? 40  ARG A HE   1 
ATOM   601  H HH11 . ARG A 1 40  ? -26.82096 -34.22848 -0.12660  1.000 29.89560  ? 40  ARG A HH11 1 
ATOM   602  H HH12 . ARG A 1 40  ? -27.83197 -33.15078 -0.31433  1.000 29.89560  ? 40  ARG A HH12 1 
ATOM   603  H HH21 . ARG A 1 40  ? -25.86842 -30.60134 0.37602   1.000 32.56339  ? 40  ARG A HH21 1 
ATOM   604  H HH22 . ARG A 1 40  ? -27.25934 -30.96668 -0.01213  1.000 32.56339  ? 40  ARG A HH22 1 
ATOM   605  N N    . HIS A 1 41  ? -19.49286 -34.09768 -0.05827  1.000 25.70059  ? 41  HIS A N    1 
ATOM   606  C CA   . HIS A 1 41  ? -18.81105 -33.56420 -1.23483  1.000 25.74104  ? 41  HIS A CA   1 
ATOM   607  C C    . HIS A 1 41  ? -17.52361 -34.33195 -1.56632  1.000 25.83197  ? 41  HIS A C    1 
ATOM   608  O O    . HIS A 1 41  ? -16.79468 -33.92141 -2.47740  1.000 27.00821  ? 41  HIS A O    1 
ATOM   609  C CB   . HIS A 1 41  ? -18.52499 -32.06921 -1.06367  1.000 28.20839  ? 41  HIS A CB   1 
ATOM   610  C CG   . HIS A 1 41  ? -17.46899 -31.75166 -0.05105  1.000 26.65709  ? 41  HIS A CG   1 
ATOM   611  N ND1  . HIS A 1 41  ? -17.76668 -31.33702 1.22889   1.000 25.14595  ? 41  HIS A ND1  1 
ATOM   612  C CD2  . HIS A 1 41  ? -16.11855 -31.75634 -0.14052  1.000 28.38978  ? 41  HIS A CD2  1 
ATOM   613  C CE1  . HIS A 1 41  ? -16.64477 -31.11895 1.89050   1.000 26.41488  ? 41  HIS A CE1  1 
ATOM   614  N NE2  . HIS A 1 41  ? -15.63012 -31.36480 1.08216   1.000 26.32730  ? 41  HIS A NE2  1 
ATOM   615  H H    . HIS A 1 41  ? -19.44712 -33.63079 0.66251   1.000 30.82775  ? 41  HIS A H    1 
ATOM   616  H HA   . HIS A 1 41  ? -19.40342 -33.64534 -1.99865  1.000 30.87630  ? 41  HIS A HA   1 
ATOM   617  H HB2  . HIS A 1 41  ? -18.23082 -31.71125 -1.91586  1.000 33.83712  ? 41  HIS A HB2  1 
ATOM   618  H HB3  . HIS A 1 41  ? -19.34213 -31.62832 -0.78293  1.000 33.83712  ? 41  HIS A HB3  1 
ATOM   619  H HD2  . HIS A 1 41  ? -15.61557 -31.98229 -0.88943  1.000 34.05478  ? 41  HIS A HD2  1 
ATOM   620  H HE1  . HIS A 1 41  ? -16.58032 -30.83973 2.77525   1.000 31.68490  ? 41  HIS A HE1  1 
ATOM   621  H HE2  . HIS A 1 41  ? -14.79829 -31.29165 1.28783   1.000 31.57980  ? 41  HIS A HE2  1 
ATOM   622  N N    . VAL A 1 42  ? -17.23805 -35.43763 -0.87228  1.000 25.69374  ? 42  VAL A N    1 
ATOM   623  C CA   . VAL A 1 42  ? -16.16452 -36.32932 -1.30394  1.000 26.89413  ? 42  VAL A CA   1 
ATOM   624  C C    . VAL A 1 42  ? -16.43118 -36.84734 -2.71007  1.000 27.27034  ? 42  VAL A C    1 
ATOM   625  O O    . VAL A 1 42  ? -15.49555 -37.18532 -3.44457  1.000 27.43347  ? 42  VAL A O    1 
ATOM   626  C CB   . VAL A 1 42  ? -16.00220 -37.49574 -0.30997  1.000 24.30855  ? 42  VAL A CB   1 
ATOM   627  C CG1  . VAL A 1 42  ? -17.18805 -38.43433 -0.40736  1.000 27.49058  ? 42  VAL A CG1  1 
ATOM   628  C CG2  . VAL A 1 42  ? -14.69492 -38.24264 -0.56497  1.000 26.27563  ? 42  VAL A CG2  1 
ATOM   629  H H    . VAL A 1 42  ? -17.64613 -35.68914 -0.15827  1.000 30.81954  ? 42  VAL A H    1 
ATOM   630  H HA   . VAL A 1 42  ? -15.33672 -35.82384 -1.31560  1.000 32.26000  ? 42  VAL A HA   1 
ATOM   631  H HB   . VAL A 1 42  ? -15.96897 -37.14088 0.59218   1.000 29.15731  ? 42  VAL A HB   1 
ATOM   632  H HG11 . VAL A 1 42  ? -17.26815 -38.92920 0.42306   1.000 32.97574  ? 42  VAL A HG11 1 
ATOM   633  H HG12 . VAL A 1 42  ? -17.99161 -37.91309 -0.56063  1.000 32.97574  ? 42  VAL A HG12 1 
ATOM   634  H HG13 . VAL A 1 42  ? -17.04571 -39.04748 -1.14539  1.000 32.97574  ? 42  VAL A HG13 1 
ATOM   635  H HG21 . VAL A 1 42  ? -14.07995 -38.06036 0.16269   1.000 31.51780  ? 42  VAL A HG21 1 
ATOM   636  H HG22 . VAL A 1 42  ? -14.87874 -39.19389 -0.61226  1.000 31.51780  ? 42  VAL A HG22 1 
ATOM   637  H HG23 . VAL A 1 42  ? -14.31501 -37.93707 -1.40354  1.000 31.51780  ? 42  VAL A HG23 1 
ATOM   638  N N    . ILE A 1 43  ? -17.70513 -36.92496 -3.10944  1.000 27.84318  ? 43  ILE A N    1 
ATOM   639  C CA   . ILE A 1 43  ? -18.05118 -37.45329 -4.42699  1.000 28.97321  ? 43  ILE A CA   1 
ATOM   640  C C    . ILE A 1 43  ? -17.89968 -36.42384 -5.53435  1.000 32.06832  ? 43  ILE A C    1 
ATOM   641  O O    . ILE A 1 43  ? -17.91318 -36.79349 -6.71622  1.000 31.57856  ? 43  ILE A O    1 
ATOM   642  C CB   . ILE A 1 43  ? -19.49016 -38.00558 -4.42151  1.000 27.76898  ? 43  ILE A CB   1 
ATOM   643  C CG1  . ILE A 1 43  ? -20.51886 -36.86769 -4.37220  1.000 26.71041  ? 43  ILE A CG1  1 
ATOM   644  C CG2  . ILE A 1 43  ? -19.68004 -38.95217 -3.23627  1.000 28.44482  ? 43  ILE A CG2  1 
ATOM   645  C CD1  . ILE A 1 43  ? -21.96320 -37.34568 -4.43639  1.000 29.33443  ? 43  ILE A CD1  1 
ATOM   646  H H    . ILE A 1 43  ? -18.38089 -36.67931 -2.63762  1.000 33.39886  ? 43  ILE A H    1 
ATOM   647  H HA   . ILE A 1 43  ? -17.44503 -38.18226 -4.63213  1.000 34.75490  ? 43  ILE A HA   1 
ATOM   648  H HB   . ILE A 1 43  ? -19.63026 -38.49638 -5.24637  1.000 33.30982  ? 43  ILE A HB   1 
ATOM   649  H HG12 . ILE A 1 43  ? -20.40485 -36.37957 -3.54175  1.000 32.03954  ? 43  ILE A HG12 1 
ATOM   650  H HG13 . ILE A 1 43  ? -20.36812 -36.27766 -5.12721  1.000 32.03954  ? 43  ILE A HG13 1 
ATOM   651  H HG21 . ILE A 1 43  ? -20.52026 -39.42531 -3.34145  1.000 34.12083  ? 43  ILE A HG21 1 
ATOM   652  H HG22 . ILE A 1 43  ? -18.94467 -39.58441 -3.21609  1.000 34.12083  ? 43  ILE A HG22 1 
ATOM   653  H HG23 . ILE A 1 43  ? -19.69286 -38.43343 -2.41673  1.000 34.12083  ? 43  ILE A HG23 1 
ATOM   654  H HD11 . ILE A 1 43  ? -22.55296 -36.57817 -4.37299  1.000 35.18837  ? 43  ILE A HD11 1 
ATOM   655  H HD12 . ILE A 1 43  ? -22.10686 -37.80451 -5.27885  1.000 35.18837  ? 43  ILE A HD12 1 
ATOM   656  H HD13 . ILE A 1 43  ? -22.12842 -37.95174 -3.69727  1.000 35.18837  ? 43  ILE A HD13 1 
ATOM   657  N N    . CYS A 1 44  ? -17.75342 -35.14766 -5.19094  1.000 30.45273  ? 44  CYS A N    1 
ATOM   658  C CA   . CYS A 1 44  ? -17.61640 -34.09973 -6.18937  1.000 33.91787  ? 44  CYS A CA   1 
ATOM   659  C C    . CYS A 1 44  ? -16.20998 -34.08259 -6.76937  1.000 38.37032  ? 44  CYS A C    1 
ATOM   660  O O    . CYS A 1 44  ? -15.22443 -34.28617 -6.05592  1.000 35.27163  ? 44  CYS A O    1 
ATOM   661  C CB   . CYS A 1 44  ? -17.91660 -32.73079 -5.57522  1.000 36.75682  ? 44  CYS A CB   1 
ATOM   662  S SG   . CYS A 1 44  ? -19.58940 -32.51916 -4.95409  1.000 32.48286  ? 44  CYS A SG   1 
ATOM   663  H H    . CYS A 1 44  ? -17.73051 -34.86303 -4.37974  1.000 36.53032  ? 44  CYS A H    1 
ATOM   664  H HA   . CYS A 1 44  ? -18.24736 -34.26970 -6.90624  1.000 40.68849  ? 44  CYS A HA   1 
ATOM   665  H HB2  . CYS A 1 44  ? -17.31104 -32.59018 -4.83063  1.000 44.09523  ? 44  CYS A HB2  1 
ATOM   666  H HB3  . CYS A 1 44  ? -17.77140 -32.05278 -6.25354  1.000 44.09523  ? 44  CYS A HB3  1 
ATOM   667  H HG   . CYS A 1 44  ? -20.35976 -32.60167 -5.87046  1.000 38.96648  ? 44  CYS A HG   1 
ATOM   668  N N    . THR A 1 45  ? -16.12265 -33.83292 -8.07248  1.000 41.49285  ? 45  THR A N    1 
ATOM   669  C CA   . THR A 1 45  ? -14.85761 -33.44704 -8.66903  1.000 45.60074  ? 45  THR A CA   1 
ATOM   670  C C    . THR A 1 45  ? -14.64599 -31.94726 -8.47537  1.000 53.46426  ? 45  THR A C    1 
ATOM   671  O O    . THR A 1 45  ? -15.51490 -31.23033 -7.97104  1.000 49.97897  ? 45  THR A O    1 
ATOM   672  C CB   . THR A 1 45  ? -14.82281 -33.79876 -10.15523 1.000 46.34404  ? 45  THR A CB   1 
ATOM   673  O OG1  . THR A 1 45  ? -15.83951 -33.06173 -10.84604 1.000 47.10203  ? 45  THR A OG1  1 
ATOM   674  C CG2  . THR A 1 45  ? -15.04860 -35.29065 -10.36257 1.000 45.13566  ? 45  THR A CG2  1 
ATOM   675  H H    . THR A 1 45  ? -16.77940 -33.88076 -8.62564  1.000 49.77846  ? 45  THR A H    1 
ATOM   676  H HA   . THR A 1 45  ? -14.13540 -33.93123 -8.23908  1.000 54.70794  ? 45  THR A HA   1 
ATOM   677  H HB   . THR A 1 45  ? -13.95322 -33.57129 -10.51988 1.000 55.59989  ? 45  THR A HB   1 
ATOM   678  H HG1  . THR A 1 45  ? -16.59366 -33.23910 -10.52140 1.000 56.50948  ? 45  THR A HG1  1 
ATOM   679  H HG21 . THR A 1 45  ? -14.97760 -35.50911 -11.30498 1.000 54.14983  ? 45  THR A HG21 1 
ATOM   680  H HG22 . THR A 1 45  ? -14.38418 -35.79823 -9.87083  1.000 54.14983  ? 45  THR A HG22 1 
ATOM   681  H HG23 . THR A 1 45  ? -15.93156 -35.53951 -10.04739 1.000 54.14983  ? 45  THR A HG23 1 
ATOM   682  N N    . SER A 1 46  ? -13.46896 -31.46836 -8.87955  1.000 65.03229  ? 46  SER A N    1 
ATOM   683  C CA   . SER A 1 46  ? -13.20441 -30.03557 -8.80248  1.000 66.86407  ? 46  SER A CA   1 
ATOM   684  C C    . SER A 1 46  ? -14.31878 -29.23714 -9.47072  1.000 63.75135  ? 46  SER A C    1 
ATOM   685  O O    . SER A 1 46  ? -14.76813 -28.21492 -8.93795  1.000 60.39378  ? 46  SER A O    1 
ATOM   686  C CB   . SER A 1 46  ? -11.85418 -29.71639 -9.44435  1.000 63.51064  ? 46  SER A CB   1 
ATOM   687  H H    . SER A 1 46  ? -12.82321 -31.94103 -9.19449  1.000 78.02580  ? 46  SER A H    1 
ATOM   688  H HA   . SER A 1 46  ? -13.16014 -29.77156 -7.87015  1.000 80.22393  ? 46  SER A HA   1 
ATOM   689  N N    . GLU A 1 47  ? -14.79162 -29.70231 -10.63060 1.000 59.27109  ? 47  GLU A N    1 
ATOM   690  C CA   . GLU A 1 47  ? -15.85308 -28.99793 -11.34441 1.000 60.53943  ? 47  GLU A CA   1 
ATOM   691  C C    . GLU A 1 47  ? -17.17612 -29.06473 -10.58972 1.000 57.42728  ? 47  GLU A C    1 
ATOM   692  O O    . GLU A 1 47  ? -17.83123 -28.03818 -10.37663 1.000 57.28519  ? 47  GLU A O    1 
ATOM   693  C CB   . GLU A 1 47  ? -16.01361 -29.58447 -12.74848 1.000 69.02899  ? 47  GLU A CB   1 
ATOM   694  C CG   . GLU A 1 47  ? -17.38115 -29.32825 -13.37547 1.000 77.42093  ? 47  GLU A CG   1 
ATOM   695  C CD   . GLU A 1 47  ? -17.39972 -29.58034 -14.87110 1.000 88.31766  ? 47  GLU A CD   1 
ATOM   696  O OE1  . GLU A 1 47  ? -16.31138 -29.74361 -15.46154 1.000 90.87217  ? 47  GLU A OE1  1 
ATOM   697  O OE2  . GLU A 1 47  ? -18.50385 -29.61466 -15.45519 1.000 90.75959  ? 47  GLU A OE2  1 
ATOM   698  H H    . GLU A 1 47  ? -14.51610 -30.41751 -11.02071 1.000 71.11235  ? 47  GLU A H    1 
ATOM   699  H HA   . GLU A 1 47  ? -15.60158 -28.06460 -11.42530 1.000 72.63437  ? 47  GLU A HA   1 
ATOM   700  H HB2  . GLU A 1 47  ? -15.34420 -29.18946 -13.32879 1.000 82.82183  ? 47  GLU A HB2  1 
ATOM   701  H HB3  . GLU A 1 47  ? -15.88615 -30.54486 -12.70062 1.000 82.82183  ? 47  GLU A HB3  1 
ATOM   702  H HG2  . GLU A 1 47  ? -18.03254 -29.91771 -12.96420 1.000 92.89216  ? 47  GLU A HG2  1 
ATOM   703  H HG3  . GLU A 1 47  ? -17.62934 -28.40276 -13.22455 1.000 92.89216  ? 47  GLU A HG3  1 
ATOM   704  N N    . ASP A 1 48  ? -17.58628 -30.27021 -10.18312 1.000 54.68405  ? 48  ASP A N    1 
ATOM   705  C CA   . ASP A 1 48  ? -18.90500 -30.46539 -9.58637  1.000 53.57590  ? 48  ASP A CA   1 
ATOM   706  C C    . ASP A 1 48  ? -19.19862 -29.48779 -8.45472  1.000 46.75161  ? 48  ASP A C    1 
ATOM   707  O O    . ASP A 1 48  ? -20.36112 -29.13245 -8.22940  1.000 41.87546  ? 48  ASP A O    1 
ATOM   708  C CB   . ASP A 1 48  ? -19.02656 -31.89591 -9.04869  1.000 48.13637  ? 48  ASP A CB   1 
ATOM   709  C CG   . ASP A 1 48  ? -19.38088 -32.90287 -10.12429 1.000 49.75747  ? 48  ASP A CG   1 
ATOM   710  O OD1  . ASP A 1 48  ? -20.22240 -32.58259 -10.99007 1.000 53.30129  ? 48  ASP A OD1  1 
ATOM   711  O OD2  . ASP A 1 48  ? -18.82474 -34.02105 -10.09617 1.000 46.60747  ? 48  ASP A OD2  1 
ATOM   712  H H    . ASP A 1 48  ? -17.11902 -30.98977 -10.24231 1.000 65.60790  ? 48  ASP A H    1 
ATOM   713  H HA   . ASP A 1 48  ? -19.56425 -30.32205 -10.28332 1.000 64.27812  ? 48  ASP A HA   1 
ATOM   714  H HB2  . ASP A 1 48  ? -18.17810 -32.15980 -8.65962  1.000 57.75069  ? 48  ASP A HB2  1 
ATOM   715  H HB3  . ASP A 1 48  ? -19.72307 -31.92119 -8.37406  1.000 57.75069  ? 48  ASP A HB3  1 
ATOM   716  N N    . MET A 1 49  ? -18.16914 -29.04601 -7.73205  1.000 47.98417  ? 49  MET A N    1 
ATOM   717  C CA   . MET A 1 49  ? -18.36557 -28.39558 -6.43989  1.000 45.53607  ? 49  MET A CA   1 
ATOM   718  C C    . MET A 1 49  ? -19.06603 -27.04154 -6.51914  1.000 42.30598  ? 49  MET A C    1 
ATOM   719  O O    . MET A 1 49  ? -19.33974 -26.46155 -5.46379  1.000 39.77948  ? 49  MET A O    1 
ATOM   720  C CB   . MET A 1 49  ? -17.01479 -28.22507 -5.73983  1.000 47.00477  ? 49  MET A CB   1 
ATOM   721  C CG   . MET A 1 49  ? -16.40040 -29.52704 -5.24162  1.000 53.23058  ? 49  MET A CG   1 
ATOM   722  S SD   . MET A 1 49  ? -14.93786 -29.25351 -4.21936  1.000 56.67238  ? 49  MET A SD   1 
ATOM   723  C CE   . MET A 1 49  ? -14.40807 -30.93607 -3.90958  1.000 40.01400  ? 49  MET A CE   1 
ATOM   724  H H    . MET A 1 49  ? -17.34529 -29.11177 -7.96984  1.000 57.56805  ? 49  MET A H    1 
ATOM   725  H HA   . MET A 1 49  ? -18.92238 -28.98145 -5.90359  1.000 54.63033  ? 49  MET A HA   1 
ATOM   726  H HB2  . MET A 1 49  ? -16.39000 -27.82518 -6.36483  1.000 56.39277  ? 49  MET A HB2  1 
ATOM   727  H HB3  . MET A 1 49  ? -17.13445 -27.64374 -4.97260  1.000 56.39277  ? 49  MET A HB3  1 
ATOM   728  H HG2  . MET A 1 49  ? -17.05583 -30.00328 -4.70822  1.000 63.86374  ? 49  MET A HG2  1 
ATOM   729  H HG3  . MET A 1 49  ? -16.13824 -30.06618 -6.00418  1.000 63.86374  ? 49  MET A HG3  1 
ATOM   730  H HE1  . MET A 1 49  ? -15.11422 -31.40838 -3.44143  1.000 48.00384  ? 49  MET A HE1  1 
ATOM   731  H HE2  . MET A 1 49  ? -14.22501 -31.37065 -4.75725  1.000 48.00384  ? 49  MET A HE2  1 
ATOM   732  H HE3  . MET A 1 49  ? -13.60472 -30.91924 -3.36621  1.000 48.00384  ? 49  MET A HE3  1 
ATOM   733  N N    . PHE A 1 50  ? -19.37855 -26.51921 -7.70258  1.000 42.96303  ? 50  PHE A N    1 
ATOM   734  C CA   . PHE A 1 50  ? -19.97162 -25.18666 -7.77571  1.000 44.62251  ? 50  PHE A CA   1 
ATOM   735  C C    . PHE A 1 50  ? -21.49582 -25.21536 -7.72196  1.000 46.43798  ? 50  PHE A C    1 
ATOM   736  O O    . PHE A 1 50  ? -22.10614 -24.34333 -7.09308  1.000 46.21842  ? 50  PHE A O    1 
ATOM   737  C CB   . PHE A 1 50  ? -19.48845 -24.46907 -9.03881  1.000 41.97395  ? 50  PHE A CB   1 
ATOM   738  C CG   . PHE A 1 50  ? -18.06519 -23.99524 -8.94447  1.000 42.26153  ? 50  PHE A CG   1 
ATOM   739  C CD1  . PHE A 1 50  ? -17.74230 -22.88609 -8.17606  1.000 43.31584  ? 50  PHE A CD1  1 
ATOM   740  C CD2  . PHE A 1 50  ? -17.04693 -24.66770 -9.59980  1.000 40.10523  ? 50  PHE A CD2  1 
ATOM   741  C CE1  . PHE A 1 50  ? -16.43177 -22.45127 -8.07119  1.000 39.52693  ? 50  PHE A CE1  1 
ATOM   742  C CE2  . PHE A 1 50  ? -15.73446 -24.23619 -9.50248  1.000 39.68360  ? 50  PHE A CE2  1 
ATOM   743  C CZ   . PHE A 1 50  ? -15.42544 -23.12617 -8.73666  1.000 37.96450  ? 50  PHE A CZ   1 
ATOM   744  H H    . PHE A 1 50  ? -19.25970 -26.90766 -8.46059  1.000 51.54268  ? 50  PHE A H    1 
ATOM   745  H HA   . PHE A 1 50  ? -19.67219 -24.66900 -7.01199  1.000 53.53405  ? 50  PHE A HA   1 
ATOM   746  N N    . ASN A 1 51  ? -22.13356 -26.19640 -8.36110  1.000 43.45190  ? 51  ASN A N    1 
ATOM   747  C CA   . ASN A 1 51  ? -23.57325 -26.41222 -8.21132  1.000 45.72955  ? 51  ASN A CA   1 
ATOM   748  C C    . ASN A 1 51  ? -23.85448 -27.90582 -8.28948  1.000 43.63015  ? 51  ASN A C    1 
ATOM   749  O O    . ASN A 1 51  ? -24.40678 -28.40563 -9.27597  1.000 41.02513  ? 51  ASN A O    1 
ATOM   750  C CB   . ASN A 1 51  ? -24.36081 -25.64455 -9.27054  1.000 52.11606  ? 51  ASN A CB   1 
ATOM   751  C CG   . ASN A 1 51  ? -25.81905 -25.46435 -8.88479  1.000 59.15043  ? 51  ASN A CG   1 
ATOM   752  O OD1  . ASN A 1 51  ? -26.19444 -25.67081 -7.72968  1.000 61.33239  ? 51  ASN A OD1  1 
ATOM   753  N ND2  . ASN A 1 51  ? -26.64560 -25.07448 -9.84602  1.000 64.02520  ? 51  ASN A ND2  1 
ATOM   754  H H    . ASN A 1 51  ? -21.75105 -26.75489 -8.89155  1.000 52.12933  ? 51  ASN A H    1 
ATOM   755  H HA   . ASN A 1 51  ? -23.85260 -26.09118 -7.33966  1.000 54.86251  ? 51  ASN A HA   1 
ATOM   756  H HB2  . ASN A 1 51  ? -23.96749 -24.76518 -9.38416  1.000 62.52632  ? 51  ASN A HB2  1 
ATOM   757  H HB3  . ASN A 1 51  ? -24.32796 -26.13337 -10.10773 1.000 62.52632  ? 51  ASN A HB3  1 
ATOM   758  H HD21 . ASN A 1 51  ? -26.34670 -24.93692 -10.64058 1.000 76.81729  ? 51  ASN A HD21 1 
ATOM   759  H HD22 . ASN A 1 51  ? -27.48045 -24.95923 -9.67472  1.000 76.81729  ? 51  ASN A HD22 1 
ATOM   760  N N    . PRO A 1 52  ? -23.49099 -28.65109 -7.25149  1.000 41.76225  ? 52  PRO A N    1 
ATOM   761  C CA   . PRO A 1 52  ? -23.69045 -30.10173 -7.28574  1.000 38.40611  ? 52  PRO A CA   1 
ATOM   762  C C    . PRO A 1 52  ? -25.15527 -30.47513 -7.15155  1.000 35.75535  ? 52  PRO A C    1 
ATOM   763  O O    . PRO A 1 52  ? -25.93190 -29.81395 -6.45959  1.000 35.72155  ? 52  PRO A O    1 
ATOM   764  C CB   . PRO A 1 52  ? -22.88529 -30.59357 -6.07838  1.000 36.18529  ? 52  PRO A CB   1 
ATOM   765  C CG   . PRO A 1 52  ? -22.93733 -29.44029 -5.12380  1.000 37.49420  ? 52  PRO A CG   1 
ATOM   766  C CD   . PRO A 1 52  ? -22.86321 -28.21201 -5.99172  1.000 41.32852  ? 52  PRO A CD   1 
ATOM   767  H HA   . PRO A 1 52  ? -23.33219 -30.47934 -8.10424  1.000 46.07438  ? 52  PRO A HA   1 
ATOM   768  H HB2  . PRO A 1 52  ? -23.29972 -31.38393 -5.69828  1.000 43.40940  ? 52  PRO A HB2  1 
ATOM   769  H HB3  . PRO A 1 52  ? -21.97294 -30.79146 -6.34174  1.000 43.40940  ? 52  PRO A HB3  1 
ATOM   770  H HG2  . PRO A 1 52  ? -23.76845 -29.46200 -4.62412  1.000 44.98009  ? 52  PRO A HG2  1 
ATOM   771  H HG3  . PRO A 1 52  ? -22.18314 -29.48066 -4.51514  1.000 44.98009  ? 52  PRO A HG3  1 
ATOM   772  H HD2  . PRO A 1 52  ? -23.35937 -27.47862 -5.59567  1.000 49.58127  ? 52  PRO A HD2  1 
ATOM   773  H HD3  . PRO A 1 52  ? -21.94150 -27.94788 -6.13868  1.000 49.58127  ? 52  PRO A HD3  1 
ATOM   774  N N    . ASN A 1 53  ? -25.52729 -31.55432 -7.82756  1.000 35.54708  ? 53  ASN A N    1 
ATOM   775  C CA   . ASN A 1 53  ? -26.78615 -32.25092 -7.57578  1.000 37.02911  ? 53  ASN A CA   1 
ATOM   776  C C    . ASN A 1 53  ? -26.37987 -33.57807 -6.93877  1.000 34.91437  ? 53  ASN A C    1 
ATOM   777  O O    . ASN A 1 53  ? -26.09871 -34.55768 -7.63012  1.000 33.61084  ? 53  ASN A O    1 
ATOM   778  C CB   . ASN A 1 53  ? -27.60264 -32.44367 -8.84435  1.000 41.24722  ? 53  ASN A CB   1 
ATOM   779  C CG   . ASN A 1 53  ? -29.02774 -32.88012 -8.55648  1.000 42.27039  ? 53  ASN A CG   1 
ATOM   780  O OD1  . ASN A 1 53  ? -29.28398 -33.62699 -7.61078  1.000 40.35710  ? 53  ASN A OD1  1 
ATOM   781  N ND2  . ASN A 1 53  ? -29.96542 -32.40784 -9.36863  1.000 42.65406  ? 53  ASN A ND2  1 
ATOM   782  H H    . ASN A 1 53  ? -25.05678 -31.91169 -8.45247  1.000 42.64354  ? 53  ASN A H    1 
ATOM   783  H HA   . ASN A 1 53  ? -27.34455 -31.74019 -6.96894  1.000 44.42198  ? 53  ASN A HA   1 
ATOM   784  H HB2  . ASN A 1 53  ? -27.63692 -31.60472 -9.33003  1.000 49.48371  ? 53  ASN A HB2  1 
ATOM   785  H HB3  . ASN A 1 53  ? -27.18315 -33.12649 -9.39087  1.000 49.48371  ? 53  ASN A HB3  1 
ATOM   786  H HD21 . ASN A 1 53  ? -30.78855 -32.62558 -9.24767  1.000 51.17191  ? 53  ASN A HD21 1 
ATOM   787  H HD22 . ASN A 1 53  ? -29.74980 -31.88410 -10.01578 1.000 51.17191  ? 53  ASN A HD22 1 
ATOM   788  N N    . TYR A 1 54  ? -26.33504 -33.59334 -5.60603  1.000 33.72771  ? 54  TYR A N    1 
ATOM   789  C CA   . TYR A 1 54  ? -25.71647 -34.71104 -4.90244  1.000 33.74795  ? 54  TYR A CA   1 
ATOM   790  C C    . TYR A 1 54  ? -26.45036 -36.01862 -5.17177  1.000 31.85477  ? 54  TYR A C    1 
ATOM   791  O O    . TYR A 1 54  ? -25.81762 -37.05743 -5.38813  1.000 31.19087  ? 54  TYR A O    1 
ATOM   792  C CB   . TYR A 1 54  ? -25.65909 -34.40921 -3.40571  1.000 31.01536  ? 54  TYR A CB   1 
ATOM   793  C CG   . TYR A 1 54  ? -24.57022 -33.42219 -3.05529  1.000 27.68978  ? 54  TYR A CG   1 
ATOM   794  C CD1  . TYR A 1 54  ? -23.23839 -33.81138 -3.04232  1.000 26.82785  ? 54  TYR A CD1  1 
ATOM   795  C CD2  . TYR A 1 54  ? -24.86920 -32.10051 -2.75104  1.000 28.57200  ? 54  TYR A CD2  1 
ATOM   796  C CE1  . TYR A 1 54  ? -22.23677 -32.91864 -2.72897  1.000 26.56991  ? 54  TYR A CE1  1 
ATOM   797  C CE2  . TYR A 1 54  ? -23.87221 -31.19968 -2.43266  1.000 28.19352  ? 54  TYR A CE2  1 
ATOM   798  C CZ   . TYR A 1 54  ? -22.55729 -31.61533 -2.42676  1.000 28.33911  ? 54  TYR A CZ   1 
ATOM   799  O OH   . TYR A 1 54  ? -21.55828 -30.72546 -2.11316  1.000 28.04715  ? 54  TYR A OH   1 
ATOM   800  H H    . TYR A 1 54  ? -26.65088 -32.97800 -5.09495  1.000 40.46030  ? 54  TYR A H    1 
ATOM   801  H HA   . TYR A 1 54  ? -24.80707 -34.82071 -5.22160  1.000 40.48459  ? 54  TYR A HA   1 
ATOM   802  H HB2  . TYR A 1 54  ? -26.50822 -34.03294 -3.12588  1.000 37.20547  ? 54  TYR A HB2  1 
ATOM   803  H HB3  . TYR A 1 54  ? -25.48596 -35.23266 -2.92314  1.000 37.20547  ? 54  TYR A HB3  1 
ATOM   804  H HD1  . TYR A 1 54  ? -23.01779 -34.69090 -3.24891  1.000 32.18046  ? 54  TYR A HD1  1 
ATOM   805  H HD2  . TYR A 1 54  ? -25.75507 -31.81763 -2.76189  1.000 34.27344  ? 54  TYR A HD2  1 
ATOM   806  H HE1  . TYR A 1 54  ? -21.34898 -33.19555 -2.72179  1.000 31.87094  ? 54  TYR A HE1  1 
ATOM   807  H HE2  . TYR A 1 54  ? -24.08597 -30.31902 -2.22372  1.000 33.81927  ? 54  TYR A HE2  1 
ATOM   808  H HH   . TYR A 1 54  ? -21.10277 -31.01934 -1.47149  1.000 33.64363  ? 54  TYR A HH   1 
ATOM   809  N N    . GLU A 1 55  ? -27.78299 -35.98806 -5.16918  1.000 33.19365  ? 55  GLU A N    1 
ATOM   810  C CA   . GLU A 1 55  ? -28.54590 -37.19144 -5.48120  1.000 34.75735  ? 55  GLU A CA   1 
ATOM   811  C C    . GLU A 1 55  ? -28.12988 -37.75002 -6.83629  1.000 34.40593  ? 55  GLU A C    1 
ATOM   812  O O    . GLU A 1 55  ? -27.90633 -38.95702 -6.98561  1.000 30.80084  ? 55  GLU A O    1 
ATOM   813  C CB   . GLU A 1 55  ? -30.04854 -36.89233 -5.47019  1.000 37.26687  ? 55  GLU A CB   1 
ATOM   814  C CG   . GLU A 1 55  ? -30.51437 -35.91985 -4.38591  1.000 48.39389  ? 55  GLU A CG   1 
ATOM   815  C CD   . GLU A 1 55  ? -30.42955 -34.46538 -4.82463  1.000 48.41422  ? 55  GLU A CD   1 
ATOM   816  O OE1  . GLU A 1 55  ? -31.22638 -34.05486 -5.69918  1.000 50.72608  ? 55  GLU A OE1  1 
ATOM   817  O OE2  . GLU A 1 55  ? -29.54919 -33.74254 -4.30585  1.000 41.55032  ? 55  GLU A OE2  1 
ATOM   818  H H    . GLU A 1 55  ? -28.26028 -35.29469 -4.99302  1.000 39.81943  ? 55  GLU A H    1 
ATOM   819  H HA   . GLU A 1 55  ? -28.37019 -37.85732 -4.79810  1.000 41.69587  ? 55  GLU A HA   1 
ATOM   820  H HB2  . GLU A 1 55  ? -30.28982 -36.50736 -6.32721  1.000 44.70729  ? 55  GLU A HB2  1 
ATOM   821  H HB3  . GLU A 1 55  ? -30.52518 -37.72627 -5.33510  1.000 44.70729  ? 55  GLU A HB3  1 
ATOM   822  H HG2  . GLU A 1 55  ? -31.43870 -36.11287 -4.16400  1.000 58.05971  ? 55  GLU A HG2  1 
ATOM   823  H HG3  . GLU A 1 55  ? -29.95489 -36.02964 -3.60117  1.000 58.05971  ? 55  GLU A HG3  1 
ATOM   824  N N    . ASP A 1 56  ? -28.00977 -36.87440 -7.83620  1.000 33.03937  ? 56  ASP A N    1 
ATOM   825  C CA   . ASP A 1 56  ? -27.62434 -37.31673 -9.17206  1.000 35.54435  ? 56  ASP A CA   1 
ATOM   826  C C    . ASP A 1 56  ? -26.18167 -37.80212 -9.19266  1.000 32.67892  ? 56  ASP A C    1 
ATOM   827  O O    . ASP A 1 56  ? -25.87615 -38.85267 -9.77066  1.000 37.18732  ? 56  ASP A O    1 
ATOM   828  C CB   . ASP A 1 56  ? -27.82393 -36.17933 -10.17554 1.000 37.54833  ? 56  ASP A CB   1 
ATOM   829  C CG   . ASP A 1 56  ? -29.28482 -35.93494 -10.49621 1.000 38.96502  ? 56  ASP A CG   1 
ATOM   830  O OD1  . ASP A 1 56  ? -30.13253 -36.74110 -10.05896 1.000 37.42455  ? 56  ASP A OD1  1 
ATOM   831  O OD2  . ASP A 1 56  ? -29.58343 -34.93544 -11.18516 1.000 39.63708  ? 56  ASP A OD2  1 
ATOM   832  H H    . ASP A 1 56  ? -28.14476 -36.02793 -7.76652  1.000 39.63428  ? 56  ASP A H    1 
ATOM   833  H HA   . ASP A 1 56  ? -28.19489 -38.05589 -9.43476  1.000 42.64027  ? 56  ASP A HA   1 
ATOM   834  H HB2  . ASP A 1 56  ? -27.45677 -35.36171 -9.80460  1.000 45.04505  ? 56  ASP A HB2  1 
ATOM   835  H HB3  . ASP A 1 56  ? -27.36805 -36.40265 -11.00210 1.000 45.04505  ? 56  ASP A HB3  1 
ATOM   836  N N    . LEU A 1 57  ? -25.27444 -37.04169 -8.57823  1.000 32.32717  ? 57  LEU A N    1 
ATOM   837  C CA   . LEU A 1 57  ? -23.88669 -37.48132 -8.49734  1.000 34.03531  ? 57  LEU A CA   1 
ATOM   838  C C    . LEU A 1 57  ? -23.77085 -38.81703 -7.77942  1.000 35.23633  ? 57  LEU A C    1 
ATOM   839  O O    . LEU A 1 57  ? -22.87826 -39.61398 -8.08932  1.000 36.16344  ? 57  LEU A O    1 
ATOM   840  C CB   . LEU A 1 57  ? -23.04301 -36.42564 -7.78272  1.000 30.71906  ? 57  LEU A CB   1 
ATOM   841  C CG   . LEU A 1 57  ? -22.62624 -35.22003 -8.62313  1.000 34.70606  ? 57  LEU A CG   1 
ATOM   842  C CD1  . LEU A 1 57  ? -22.22036 -34.05543 -7.73112  1.000 35.47029  ? 57  LEU A CD1  1 
ATOM   843  C CD2  . LEU A 1 57  ? -21.48525 -35.60700 -9.55263  1.000 40.47979  ? 57  LEU A CD2  1 
ATOM   844  H H    . LEU A 1 57  ? -25.43494 -36.28231 -8.20787  1.000 38.77965  ? 57  LEU A H    1 
ATOM   845  H HA   . LEU A 1 57  ? -23.53840 -37.58718 -9.39644  1.000 40.82941  ? 57  LEU A HA   1 
ATOM   846  H HB2  . LEU A 1 57  ? -23.55421 -36.08842 -7.03048  1.000 36.84992  ? 57  LEU A HB2  1 
ATOM   847  H HB3  . LEU A 1 57  ? -22.23012 -36.85079 -7.46751  1.000 36.84992  ? 57  LEU A HB3  1 
ATOM   848  H HG   . LEU A 1 57  ? -23.37841 -34.92924 -9.16219  1.000 41.63432  ? 57  LEU A HG   1 
ATOM   849  H HD11 . LEU A 1 57  ? -21.91529 -33.32231 -8.28823  1.000 42.55139  ? 57  LEU A HD11 1 
ATOM   850  H HD12 . LEU A 1 57  ? -22.98781 -33.77605 -7.20780  1.000 42.55139  ? 57  LEU A HD12 1 
ATOM   851  H HD13 . LEU A 1 57  ? -21.50533 -34.34303 -7.14212  1.000 42.55139  ? 57  LEU A HD13 1 
ATOM   852  H HD21 . LEU A 1 57  ? -21.76392 -36.35863 -10.09878 1.000 48.56279  ? 57  LEU A HD21 1 
ATOM   853  H HD22 . LEU A 1 57  ? -21.26806 -34.84958 -10.11835 1.000 48.56279  ? 57  LEU A HD22 1 
ATOM   854  H HD23 . LEU A 1 57  ? -20.71340 -35.85370 -9.01945  1.000 48.56279  ? 57  LEU A HD23 1 
ATOM   855  N N    . LEU A 1 58  ? -24.66496 -39.07959 -6.82371  1.000 33.17305  ? 58  LEU A N    1 
ATOM   856  C CA   . LEU A 1 58  ? -24.58952 -40.29009 -6.01846  1.000 32.47778  ? 58  LEU A CA   1 
ATOM   857  C C    . LEU A 1 58  ? -25.06836 -41.52224 -6.76877  1.000 35.88480  ? 58  LEU A C    1 
ATOM   858  O O    . LEU A 1 58  ? -24.68317 -42.63738 -6.40379  1.000 38.07796  ? 58  LEU A O    1 
ATOM   859  C CB   . LEU A 1 58  ? -25.41336 -40.10475 -4.74248  1.000 32.37056  ? 58  LEU A CB   1 
ATOM   860  C CG   . LEU A 1 58  ? -25.05492 -40.93146 -3.51076  1.000 32.15955  ? 58  LEU A CG   1 
ATOM   861  C CD1  . LEU A 1 58  ? -23.58767 -40.77308 -3.15350  1.000 29.53898  ? 58  LEU A CD1  1 
ATOM   862  C CD2  . LEU A 1 58  ? -25.93740 -40.50817 -2.34146  1.000 31.70982  ? 58  LEU A CD2  1 
ATOM   863  H H    . LEU A 1 58  ? -25.32660 -38.56781 -6.62394  1.000 39.79470  ? 58  LEU A H    1 
ATOM   864  H HA   . LEU A 1 58  ? -23.66689 -40.44616 -5.76292  1.000 38.96039  ? 58  LEU A HA   1 
ATOM   865  H HB2  . LEU A 1 58  ? -25.33925 -39.17381 -4.48027  1.000 38.83172  ? 58  LEU A HB2  1 
ATOM   866  H HB3  . LEU A 1 58  ? -26.33526 -40.31650 -4.95737  1.000 38.83172  ? 58  LEU A HB3  1 
ATOM   867  H HG   . LEU A 1 58  ? -25.20688 -41.87068 -3.69959  1.000 38.57851  ? 58  LEU A HG   1 
ATOM   868  H HD11 . LEU A 1 58  ? -23.46560 -40.99074 -2.21615  1.000 35.43382  ? 58  LEU A HD11 1 
ATOM   869  H HD12 . LEU A 1 58  ? -23.06194 -41.37440 -3.70389  1.000 35.43382  ? 58  LEU A HD12 1 
ATOM   870  H HD13 . LEU A 1 58  ? -23.31998 -39.85530 -3.31755  1.000 35.43382  ? 58  LEU A HD13 1 
ATOM   871  H HD21 . LEU A 1 58  ? -25.66040 -39.62923 -2.03875  1.000 38.03883  ? 58  LEU A HD21 1 
ATOM   872  H HD22 . LEU A 1 58  ? -26.86097 -40.48048 -2.63668  1.000 38.03883  ? 58  LEU A HD22 1 
ATOM   873  H HD23 . LEU A 1 58  ? -25.83912 -41.15181 -1.62245  1.000 38.03883  ? 58  LEU A HD23 1 
ATOM   874  N N    . ILE A 1 59  ? -25.87972 -41.34967 -7.81530  1.000 35.71143  ? 59  ILE A N    1 
ATOM   875  C CA   . ILE A 1 59  ? -26.36117 -42.49804 -8.57427  1.000 37.36226  ? 59  ILE A CA   1 
ATOM   876  C C    . ILE A 1 59  ? -25.18920 -43.27493 -9.15515  1.000 40.63108  ? 59  ILE A C    1 
ATOM   877  O O    . ILE A 1 59  ? -25.22258 -44.50770 -9.23939  1.000 43.13259  ? 59  ILE A O    1 
ATOM   878  C CB   . ILE A 1 59  ? -27.32567 -42.04936 -9.69056  1.000 39.28915  ? 59  ILE A CB   1 
ATOM   879  C CG1  . ILE A 1 59  ? -28.49574 -41.21941 -9.14093  1.000 41.13331  ? 59  ILE A CG1  1 
ATOM   880  C CG2  . ILE A 1 59  ? -27.81408 -43.26105 -10.48735 1.000 49.48263  ? 59  ILE A CG2  1 
ATOM   881  C CD1  . ILE A 1 59  ? -29.10544 -41.72114 -7.84013  1.000 45.04799  ? 59  ILE A CD1  1 
ATOM   882  H H    . ILE A 1 59  ? -26.16063 -40.58843 -8.10027  1.000 42.84077  ? 59  ILE A H    1 
ATOM   883  H HA   . ILE A 1 59  ? -26.84856 -43.07602 -7.96658  1.000 44.82176  ? 59  ILE A HA   1 
ATOM   884  H HB   . ILE A 1 59  ? -26.83461 -41.46641 -10.29050 1.000 47.13402  ? 59  ILE A HB   1 
ATOM   885  H HG12 . ILE A 1 59  ? -28.17996 -40.31623 -8.98138  1.000 49.34701  ? 59  ILE A HG12 1 
ATOM   886  H HG13 . ILE A 1 59  ? -29.20208 -41.21132 -9.80570  1.000 49.34701  ? 59  ILE A HG13 1 
ATOM   887  H HG21 . ILE A 1 59  ? -27.11402 -43.54064 -11.09779 1.000 59.36620  ? 59  ILE A HG21 1 
ATOM   888  H HG22 . ILE A 1 59  ? -28.02279 -43.98076 -9.87144  1.000 59.36620  ? 59  ILE A HG22 1 
ATOM   889  H HG23 . ILE A 1 59  ? -28.60784 -43.01191 -10.98614 1.000 59.36620  ? 59  ILE A HG23 1 
ATOM   890  H HD11 . ILE A 1 59  ? -29.85980 -41.15769 -7.60696  1.000 54.04463  ? 59  ILE A HD11 1 
ATOM   891  H HD12 . ILE A 1 59  ? -29.40178 -42.63659 -7.96270  1.000 54.04463  ? 59  ILE A HD12 1 
ATOM   892  H HD13 . ILE A 1 59  ? -28.43436 -41.68150 -7.14087  1.000 54.04463  ? 59  ILE A HD13 1 
ATOM   893  N N    . ARG A 1 60  ? -24.14239 -42.56942 -9.57587  1.000 42.05871  ? 60  ARG A N    1 
ATOM   894  C CA   . ARG A 1 60  ? -23.03220 -43.18224 -10.28989 1.000 47.86914  ? 60  ARG A CA   1 
ATOM   895  C C    . ARG A 1 60  ? -21.91989 -43.65354 -9.36394  1.000 41.30590  ? 60  ARG A C    1 
ATOM   896  O O    . ARG A 1 60  ? -20.86893 -44.08292 -9.85002  1.000 39.46598  ? 60  ARG A O    1 
ATOM   897  C CB   . ARG A 1 60  ? -22.47702 -42.20283 -11.32960 1.000 54.63769  ? 60  ARG A CB   1 
ATOM   898  C CG   . ARG A 1 60  ? -23.45740 -41.92409 -12.46146 1.000 65.92607  ? 60  ARG A CG   1 
ATOM   899  C CD   . ARG A 1 60  ? -22.79800 -41.26567 -13.66410 1.000 82.65526  ? 60  ARG A CD   1 
ATOM   900  N NE   . ARG A 1 60  ? -21.95299 -40.13408 -13.30037 1.000 85.96598  ? 60  ARG A NE   1 
ATOM   901  C CZ   . ARG A 1 60  ? -22.40420 -38.97054 -12.85045 1.000 74.84668  ? 60  ARG A CZ   1 
ATOM   902  N NH1  . ARG A 1 60  ? -23.69272 -38.76651 -12.62801 1.000 68.70938  ? 60  ARG A NH1  1 
ATOM   903  N NH2  . ARG A 1 60  ? -21.53980 -37.98783 -12.61357 1.000 67.73862  ? 60  ARG A NH2  1 
ATOM   904  H H    . ARG A 1 60  ? -24.05352 -41.72237 -9.45668  1.000 50.45750  ? 60  ARG A H    1 
ATOM   905  H HA   . ARG A 1 60  ? -23.36164 -43.96189 -10.76372 1.000 57.43001  ? 60  ARG A HA   1 
ATOM   906  H HB2  . ARG A 1 60  ? -22.27518 -41.36042 -10.89313 1.000 65.55227  ? 60  ARG A HB2  1 
ATOM   907  H HB3  . ARG A 1 60  ? -21.67039 -42.57753 -11.71671 1.000 65.55227  ? 60  ARG A HB3  1 
ATOM   908  H HG2  . ARG A 1 60  ? -23.84757 -42.76206 -12.75552 1.000 79.09833  ? 60  ARG A HG2  1 
ATOM   909  H HG3  . ARG A 1 60  ? -24.15260 -41.32967 -12.13857 1.000 79.09833  ? 60  ARG A HG3  1 
ATOM   910  H HD2  . ARG A 1 60  ? -22.24312 -41.91970 -14.11715 1.000 99.17336  ? 60  ARG A HD2  1 
ATOM   911  H HD3  . ARG A 1 60  ? -23.48781 -40.94279 -14.26477 1.000 99.17336  ? 60  ARG A HD3  1 
ATOM   912  H HE   . ARG A 1 60  ? -21.10214 -40.22768 -13.38342 1.000 103.14622 ? 60  ARG A HE   1 
ATOM   913  H HH11 . ARG A 1 60  ? -24.25951 -39.39632 -12.77528 1.000 82.43830  ? 60  ARG A HH11 1 
ATOM   914  H HH12 . ARG A 1 60  ? -23.96327 -38.00412 -12.33618 1.000 82.43830  ? 60  ARG A HH12 1 
ATOM   915  H HH21 . ARG A 1 60  ? -20.70005 -38.11108 -12.75223 1.000 81.27339  ? 60  ARG A HH21 1 
ATOM   916  H HH22 . ARG A 1 60  ? -21.82063 -37.22917 -12.32174 1.000 81.27339  ? 60  ARG A HH22 1 
ATOM   917  N N    . LYS A 1 61  ? -22.12595 -43.59157 -8.05106  1.000 37.06618  ? 61  LYS A N    1 
ATOM   918  C CA   . LYS A 1 61  ? -21.16468 -44.09346 -7.07910  1.000 36.82519  ? 61  LYS A CA   1 
ATOM   919  C C    . LYS A 1 61  ? -21.69723 -45.38693 -6.48161  1.000 34.68641  ? 61  LYS A C    1 
ATOM   920  O O    . LYS A 1 61  ? -22.85914 -45.45074 -6.06797  1.000 35.42321  ? 61  LYS A O    1 
ATOM   921  C CB   . LYS A 1 61  ? -20.90349 -43.06533 -5.97554  1.000 35.49260  ? 61  LYS A CB   1 
ATOM   922  C CG   . LYS A 1 61  ? -20.42708 -41.71380 -6.49029  1.000 35.26820  ? 61  LYS A CG   1 
ATOM   923  C CD   . LYS A 1 61  ? -19.10154 -41.84539 -7.21706  1.000 34.40422  ? 61  LYS A CD   1 
ATOM   924  C CE   . LYS A 1 61  ? -18.59159 -40.50630 -7.69929  1.000 36.56376  ? 61  LYS A CE   1 
ATOM   925  N NZ   . LYS A 1 61  ? -17.39726 -40.67951 -8.57381  1.000 52.05677  ? 61  LYS A NZ   1 
ATOM   926  H H    . LYS A 1 61  ? -22.83197 -43.25509 -7.69340  1.000 44.46646  ? 61  LYS A H    1 
ATOM   927  H HA   . LYS A 1 61  ? -20.32057 -44.27834 -7.51978  1.000 44.17728  ? 61  LYS A HA   1 
ATOM   928  H HB2  . LYS A 1 61  ? -21.72711 -42.92055 -5.48402  1.000 42.57816  ? 61  LYS A HB2  1 
ATOM   929  H HB3  . LYS A 1 61  ? -20.21965 -43.41305 -5.38196  1.000 42.57816  ? 61  LYS A HB3  1 
ATOM   930  H HG2  . LYS A 1 61  ? -21.08204 -41.35439 -7.10897  1.000 42.30889  ? 61  LYS A HG2  1 
ATOM   931  H HG3  . LYS A 1 61  ? -20.30854 -41.10681 -5.74302  1.000 42.30889  ? 61  LYS A HG3  1 
ATOM   932  H HD2  . LYS A 1 61  ? -18.44178 -42.22255 -6.61427  1.000 41.27211  ? 61  LYS A HD2  1 
ATOM   933  H HD3  . LYS A 1 61  ? -19.21493 -42.42287 -7.98814  1.000 41.27211  ? 61  LYS A HD3  1 
ATOM   934  H HE2  . LYS A 1 61  ? -19.28530 -40.06028 -8.20991  1.000 43.86355  ? 61  LYS A HE2  1 
ATOM   935  H HE3  . LYS A 1 61  ? -18.33901 -39.96224 -6.93699  1.000 43.86355  ? 61  LYS A HE3  1 
ATOM   936  H HZ1  . LYS A 1 61  ? -17.65304 -40.88373 -9.40144  1.000 62.45516  ? 61  LYS A HZ1  1 
ATOM   937  H HZ2  . LYS A 1 61  ? -16.92395 -39.92611 -8.59540  1.000 62.45516  ? 61  LYS A HZ2  1 
ATOM   938  H HZ3  . LYS A 1 61  ? -16.88299 -41.33482 -8.26044  1.000 62.45516  ? 61  LYS A HZ3  1 
ATOM   939  N N    . SER A 1 62  ? -20.85358 -46.41158 -6.45391  1.000 33.82705  ? 62  SER A N    1 
ATOM   940  C CA   . SER A 1 62  ? -21.16847 -47.68571 -5.82829  1.000 32.94533  ? 62  SER A CA   1 
ATOM   941  C C    . SER A 1 62  ? -20.23100 -47.89141 -4.64518  1.000 29.55412  ? 62  SER A C    1 
ATOM   942  O O    . SER A 1 62  ? -19.25937 -47.15481 -4.46040  1.000 29.09877  ? 62  SER A O    1 
ATOM   943  C CB   . SER A 1 62  ? -21.04757 -48.83934 -6.83252  1.000 33.94434  ? 62  SER A CB   1 
ATOM   944  O OG   . SER A 1 62  ? -21.72401 -48.53284 -8.04054  1.000 36.65784  ? 62  SER A OG   1 
ATOM   945  H H    . SER A 1 62  ? -20.06780 -46.39006 -6.80275  1.000 40.57951  ? 62  SER A H    1 
ATOM   946  H HA   . SER A 1 62  ? -22.08189 -47.68234 -5.50189  1.000 39.52144  ? 62  SER A HA   1 
ATOM   947  H HB2  . SER A 1 62  ? -20.10942 -48.99171 -7.02633  1.000 40.72025  ? 62  SER A HB2  1 
ATOM   948  H HB3  . SER A 1 62  ? -21.44012 -49.63723 -6.44498  1.000 40.72025  ? 62  SER A HB3  1 
ATOM   949  H HG   . SER A 1 62  ? -21.31233 -48.86565 -8.69274  1.000 43.97645  ? 62  SER A HG   1 
ATOM   950  N N    . ASN A 1 63  ? -20.53199 -48.91345 -3.83902  1.000 31.86255  ? 63  ASN A N    1 
ATOM   951  C CA   . ASN A 1 63  ? -19.75645 -49.14829 -2.62373  1.000 29.25049  ? 63  ASN A CA   1 
ATOM   952  C C    . ASN A 1 63  ? -18.25615 -49.16989 -2.90278  1.000 29.36038  ? 63  ASN A C    1 
ATOM   953  O O    . ASN A 1 63  ? -17.46136 -48.67549 -2.09701  1.000 28.56648  ? 63  ASN A O    1 
ATOM   954  C CB   . ASN A 1 63  ? -20.18319 -50.46382 -1.96861  1.000 27.93821  ? 63  ASN A CB   1 
ATOM   955  C CG   . ASN A 1 63  ? -21.57548 -50.39989 -1.36844  1.000 29.72049  ? 63  ASN A CG   1 
ATOM   956  O OD1  . ASN A 1 63  ? -22.04859 -49.33675 -0.96200  1.000 27.82503  ? 63  ASN A OD1  1 
ATOM   957  N ND2  . ASN A 1 63  ? -22.23626 -51.54842 -1.30057  1.000 29.68564  ? 63  ASN A ND2  1 
ATOM   958  H H    . ASN A 1 63  ? -21.16965 -49.47495 -3.97208  1.000 38.22211  ? 63  ASN A H    1 
ATOM   959  H HA   . ASN A 1 63  ? -19.93870 -48.42325 -2.00566  1.000 35.08763  ? 63  ASN A HA   1 
ATOM   960  H HB2  . ASN A 1 63  ? -20.17759 -51.16600 -2.63779  1.000 33.51290  ? 63  ASN A HB2  1 
ATOM   961  H HB3  . ASN A 1 63  ? -19.56002 -50.67871 -1.25701  1.000 33.51290  ? 63  ASN A HB3  1 
ATOM   962  H HD21 . ASN A 1 63  ? -23.02955 -51.56917 -0.96913  1.000 35.60982  ? 63  ASN A HD21 1 
ATOM   963  H HD22 . ASN A 1 63  ? -21.87127 -52.27214 -1.58801  1.000 35.60982  ? 63  ASN A HD22 1 
ATOM   964  N N    . HIS A 1 64  ? -17.84470 -49.74514 -4.03500  1.000 30.21533  ? 64  HIS A N    1 
ATOM   965  C CA   . HIS A 1 64  ? -16.42016 -49.88960 -4.30955  1.000 30.36064  ? 64  HIS A CA   1 
ATOM   966  C C    . HIS A 1 64  ? -15.76507 -48.59381 -4.77301  1.000 28.59435  ? 64  HIS A C    1 
ATOM   967  O O    . HIS A 1 64  ? -14.54276 -48.56858 -4.94531  1.000 29.82705  ? 64  HIS A O    1 
ATOM   968  C CB   . HIS A 1 64  ? -16.18553 -50.98912 -5.35498  1.000 31.68355  ? 64  HIS A CB   1 
ATOM   969  C CG   . HIS A 1 64  ? -16.66771 -50.64176 -6.72862  1.000 30.33299  ? 64  HIS A CG   1 
ATOM   970  N ND1  . HIS A 1 64  ? -17.88117 -51.06912 -7.22001  1.000 32.71720  ? 64  HIS A ND1  1 
ATOM   971  C CD2  . HIS A 1 64  ? -16.09375 -49.91925 -7.72060  1.000 32.94071  ? 64  HIS A CD2  1 
ATOM   972  C CE1  . HIS A 1 64  ? -18.03882 -50.61889 -8.45158  1.000 34.36430  ? 64  HIS A CE1  1 
ATOM   973  N NE2  . HIS A 1 64  ? -16.96876 -49.91861 -8.77984  1.000 32.51061  ? 64  HIS A NE2  1 
ATOM   974  H H    . HIS A 1 64  ? -18.36411 -50.05340 -4.64721  1.000 36.24545  ? 64  HIS A H    1 
ATOM   975  H HA   . HIS A 1 64  ? -15.97973 -50.16478 -3.49028  1.000 36.41981  ? 64  HIS A HA   1 
ATOM   976  H HB2  . HIS A 1 64  ? -15.23320 -51.16405 -5.41289  1.000 38.00730  ? 64  HIS A HB2  1 
ATOM   977  H HB3  . HIS A 1 64  ? -16.65350 -51.79053 -5.07276  1.000 38.00730  ? 64  HIS A HB3  1 
ATOM   978  H HD2  . HIS A 1 64  ? -15.26319 -49.50195 -7.69024  1.000 39.51589  ? 64  HIS A HD2  1 
ATOM   979  H HE1  . HIS A 1 64  ? -18.77811 -50.76955 -8.99531  1.000 41.22420  ? 64  HIS A HE1  1 
ATOM   980  H HE2  . HIS A 1 64  ? -16.84034 -49.52591 -9.53409  1.000 38.99978  ? 64  HIS A HE2  1 
ATOM   981  N N    . ASN A 1 65  ? -16.53396 -47.52597 -4.97910  1.000 28.16496  ? 65  ASN A N    1 
ATOM   982  C CA   . ASN A 1 65  ? -15.94931 -46.23559 -5.32045  1.000 29.50697  ? 65  ASN A CA   1 
ATOM   983  C C    . ASN A 1 65  ? -15.47297 -45.45896 -4.10110  1.000 28.54019  ? 65  ASN A C    1 
ATOM   984  O O    . ASN A 1 65  ? -14.73323 -44.48431 -4.26270  1.000 27.06226  ? 65  ASN A O    1 
ATOM   985  C CB   . ASN A 1 65  ? -16.95743 -45.38338 -6.09059  1.000 31.48850  ? 65  ASN A CB   1 
ATOM   986  C CG   . ASN A 1 65  ? -17.28238 -45.95579 -7.45406  1.000 32.66742  ? 65  ASN A CG   1 
ATOM   987  O OD1  . ASN A 1 65  ? -18.44511 -46.17156 -7.78440  1.000 33.72619  ? 65  ASN A OD1  1 
ATOM   988  N ND2  . ASN A 1 65  ? -16.25217 -46.20515 -8.25383  1.000 31.87516  ? 65  ASN A ND2  1 
ATOM   989  H H    . ASN A 1 65  ? -17.39238 -47.52489 -4.92701  1.000 33.78500  ? 65  ASN A H    1 
ATOM   990  H HA   . ASN A 1 65  ? -15.18522 -46.39233 -5.89708  1.000 35.39541  ? 65  ASN A HA   1 
ATOM   991  H HB2  . ASN A 1 65  ? -17.78190 -45.33141 -5.58221  1.000 37.77324  ? 65  ASN A HB2  1 
ATOM   992  H HB3  . ASN A 1 65  ? -16.58941 -44.49494 -6.21757  1.000 37.77324  ? 65  ASN A HB3  1 
ATOM   993  H HD21 . ASN A 1 65  ? -16.38589 -46.53080 -9.03847  1.000 38.23724  ? 65  ASN A HD21 1 
ATOM   994  H HD22 . ASN A 1 65  ? -15.45120 -46.04101 -7.98716  1.000 38.23724  ? 65  ASN A HD22 1 
ATOM   995  N N    . PHE A 1 66  ? -15.88120 -45.85835 -2.89650  1.000 29.14432  ? 66  PHE A N    1 
ATOM   996  C CA   . PHE A 1 66  ? -15.47667 -45.19787 -1.65976  1.000 30.56790  ? 66  PHE A CA   1 
ATOM   997  C C    . PHE A 1 66  ? -14.32072 -45.98931 -1.05485  1.000 30.23983  ? 66  PHE A C    1 
ATOM   998  O O    . PHE A 1 66  ? -14.52266 -47.07164 -0.49571  1.000 29.27856  ? 66  PHE A O    1 
ATOM   999  C CB   . PHE A 1 66  ? -16.64780 -45.10140 -0.68422  1.000 27.79973  ? 66  PHE A CB   1 
ATOM   1000 C CG   . PHE A 1 66  ? -17.82700 -44.34591 -1.22306  1.000 26.06569  ? 66  PHE A CG   1 
ATOM   1001 C CD1  . PHE A 1 66  ? -17.84410 -42.96243 -1.20559  1.000 26.34165  ? 66  PHE A CD1  1 
ATOM   1002 C CD2  . PHE A 1 66  ? -18.92403 -45.01801 -1.73077  1.000 27.08615  ? 66  PHE A CD2  1 
ATOM   1003 C CE1  . PHE A 1 66  ? -18.93046 -42.26018 -1.69479  1.000 28.57468  ? 66  PHE A CE1  1 
ATOM   1004 C CE2  . PHE A 1 66  ? -20.01039 -44.32419 -2.22201  1.000 27.90489  ? 66  PHE A CE2  1 
ATOM   1005 C CZ   . PHE A 1 66  ? -20.01435 -42.94144 -2.20309  1.000 29.82363  ? 66  PHE A CZ   1 
ATOM   1006 H H    . PHE A 1 66  ? -16.40651 -46.52722 -2.76892  1.000 34.96023  ? 66  PHE A H    1 
ATOM   1007 H HA   . PHE A 1 66  ? -15.17127 -44.29839 -1.85612  1.000 36.66852  ? 66  PHE A HA   1 
ATOM   1008 H HB2  . PHE A 1 66  ? -16.94607 -45.99827 -0.46615  1.000 33.34672  ? 66  PHE A HB2  1 
ATOM   1009 H HB3  . PHE A 1 66  ? -16.34768 -44.64720 0.11861   1.000 33.34672  ? 66  PHE A HB3  1 
ATOM   1010 H HD1  . PHE A 1 66  ? -17.11558 -42.49877 -0.86039  1.000 31.59703  ? 66  PHE A HD1  1 
ATOM   1011 H HD2  . PHE A 1 66  ? -18.92933 -45.94793 -1.74109  1.000 32.49042  ? 66  PHE A HD2  1 
ATOM   1012 H HE1  . PHE A 1 66  ? -18.92918 -41.33029 -1.68061  1.000 34.27667  ? 66  PHE A HE1  1 
ATOM   1013 H HE2  . PHE A 1 66  ? -20.74035 -44.78647 -2.56602  1.000 33.47291  ? 66  PHE A HE2  1 
ATOM   1014 H HZ   . PHE A 1 66  ? -20.74688 -42.47275 -2.53268  1.000 35.77540  ? 66  PHE A HZ   1 
ATOM   1015 N N    . LEU A 1 67  ? -13.11249 -45.45487 -1.17263  1.000 29.63166  ? 67  LEU A N    1 
ATOM   1016 C CA   . LEU A 1 67  ? -11.92553 -46.08925 -0.60984  1.000 32.72486  ? 67  LEU A CA   1 
ATOM   1017 C C    . LEU A 1 67  ? -11.73049 -45.57318 0.81186   1.000 31.15500  ? 67  LEU A C    1 
ATOM   1018 O O    . LEU A 1 67  ? -11.44232 -44.38854 1.01883   1.000 28.45185  ? 67  LEU A O    1 
ATOM   1019 C CB   . LEU A 1 67  ? -10.70038 -45.80967 -1.47537  1.000 38.62866  ? 67  LEU A CB   1 
ATOM   1020 C CG   . LEU A 1 67  ? -10.76391 -46.30887 -2.92358  1.000 43.34336  ? 67  LEU A CG   1 
ATOM   1021 C CD1  . LEU A 1 67  ? -9.55359  -45.81146 -3.70701  1.000 44.77526  ? 67  LEU A CD1  1 
ATOM   1022 C CD2  . LEU A 1 67  ? -10.85653 -47.83232 -2.99035  1.000 42.61208  ? 67  LEU A CD2  1 
ATOM   1023 H H    . LEU A 1 67  ? -12.95082 -44.71475 -1.57966  1.000 35.54503  ? 67  LEU A H    1 
ATOM   1024 H HA   . LEU A 1 67  ? -12.05625 -47.04977 -0.57488  1.000 39.25688  ? 67  LEU A HA   1 
ATOM   1025 H HB2  . LEU A 1 67  ? -10.56843 -44.84929 -1.50948  1.000 46.34144  ? 67  LEU A HB2  1 
ATOM   1026 H HB3  . LEU A 1 67  ? -9.93430  -46.23524 -1.05956  1.000 46.34144  ? 67  LEU A HB3  1 
ATOM   1027 H HG   . LEU A 1 67  ? -11.56742 -45.95405 -3.33511  1.000 51.99908  ? 67  LEU A HG   1 
ATOM   1028 H HD11 . LEU A 1 67  ? -9.34694  -44.90587 -3.42756  1.000 53.71736  ? 67  LEU A HD11 1 
ATOM   1029 H HD12 . LEU A 1 67  ? -8.79921  -46.39375 -3.52605  1.000 53.71736  ? 67  LEU A HD12 1 
ATOM   1030 H HD13 . LEU A 1 67  ? -9.76278  -45.82579 -4.65407  1.000 53.71736  ? 67  LEU A HD13 1 
ATOM   1031 H HD21 . LEU A 1 67  ? -11.34331 -48.08434 -3.79062  1.000 51.12154  ? 67  LEU A HD21 1 
ATOM   1032 H HD22 . LEU A 1 67  ? -9.96028  -48.20228 -3.01807  1.000 51.12154  ? 67  LEU A HD22 1 
ATOM   1033 H HD23 . LEU A 1 67  ? -11.32343 -48.15510 -2.20376  1.000 51.12154  ? 67  LEU A HD23 1 
ATOM   1034 N N    . VAL A 1 68  ? -11.88786 -46.46502 1.78650   1.000 32.16744  ? 68  VAL A N    1 
ATOM   1035 C CA   . VAL A 1 68  ? -11.77941 -46.13796 3.20295   1.000 29.16580  ? 68  VAL A CA   1 
ATOM   1036 C C    . VAL A 1 68  ? -10.56125 -46.85481 3.76568   1.000 30.94908  ? 68  VAL A C    1 
ATOM   1037 O O    . VAL A 1 68  ? -10.44165 -48.07896 3.64073   1.000 29.53970  ? 68  VAL A O    1 
ATOM   1038 C CB   . VAL A 1 68  ? -13.04988 -46.54290 3.96829   1.000 28.21368  ? 68  VAL A CB   1 
ATOM   1039 C CG1  . VAL A 1 68  ? -12.95624 -46.09809 5.41756   1.000 29.83540  ? 68  VAL A CG1  1 
ATOM   1040 C CG2  . VAL A 1 68  ? -14.28436 -45.96090 3.29018   1.000 27.29640  ? 68  VAL A CG2  1 
ATOM   1041 H H    . VAL A 1 68  ? -12.06427 -47.29479 1.64522   1.000 38.58798  ? 68  VAL A H    1 
ATOM   1042 H HA   . VAL A 1 68  ? -11.64901 -45.18201 3.30324   1.000 34.98600  ? 68  VAL A HA   1 
ATOM   1043 H HB   . VAL A 1 68  ? -13.13581 -47.50905 3.96006   1.000 33.84346  ? 68  VAL A HB   1 
ATOM   1044 H HG11 . VAL A 1 68  ? -12.31388 -45.37439 5.48491   1.000 35.78953  ? 68  VAL A HG11 1 
ATOM   1045 H HG12 . VAL A 1 68  ? -13.82915 -45.79401 5.71160   1.000 35.78953  ? 68  VAL A HG12 1 
ATOM   1046 H HG13 . VAL A 1 68  ? -12.66728 -46.84842 5.96015   1.000 35.78953  ? 68  VAL A HG13 1 
ATOM   1047 H HG21 . VAL A 1 68  ? -14.12303 -45.02573 3.08938   1.000 32.74273  ? 68  VAL A HG21 1 
ATOM   1048 H HG22 . VAL A 1 68  ? -14.45479 -46.45062 2.47041   1.000 32.74273  ? 68  VAL A HG22 1 
ATOM   1049 H HG23 . VAL A 1 68  ? -15.04270 -46.04454 3.88920   1.000 32.74273  ? 68  VAL A HG23 1 
ATOM   1050 N N    . GLN A 1 69  ? -9.66878  -46.09611 4.39589   1.000 30.93498  ? 69  GLN A N    1 
ATOM   1051 C CA   . GLN A 1 69  ? -8.40531  -46.62175 4.89128   1.000 33.32090  ? 69  GLN A CA   1 
ATOM   1052 C C    . GLN A 1 69  ? -8.20527  -46.19054 6.33724   1.000 31.21440  ? 69  GLN A C    1 
ATOM   1053 O O    . GLN A 1 69  ? -8.27951  -44.99764 6.65028   1.000 29.05382  ? 69  GLN A O    1 
ATOM   1054 C CB   . GLN A 1 69  ? -7.24458  -46.13691 4.01808   1.000 36.39477  ? 69  GLN A CB   1 
ATOM   1055 C CG   . GLN A 1 69  ? -5.96537  -46.92324 4.19546   1.000 42.03006  ? 69  GLN A CG   1 
ATOM   1056 C CD   . GLN A 1 69  ? -4.87329  -46.46717 3.25090   1.000 45.45377  ? 69  GLN A CD   1 
ATOM   1057 O OE1  . GLN A 1 69  ? -5.11666  -46.24870 2.06413   1.000 44.16179  ? 69  GLN A OE1  1 
ATOM   1058 N NE2  . GLN A 1 69  ? -3.66256  -46.31303 3.77601   1.000 44.46977  ? 69  GLN A NE2  1 
ATOM   1059 H H    . GLN A 1 69  ? -9.77699  -45.25705 4.55040   1.000 37.10902  ? 69  GLN A H    1 
ATOM   1060 H HA   . GLN A 1 69  ? -8.42303  -47.59146 4.87572   1.000 39.97212  ? 69  GLN A HA   1 
ATOM   1061 H HB2  . GLN A 1 69  ? -7.50661  -46.20737 3.08680   1.000 43.66077  ? 69  GLN A HB2  1 
ATOM   1062 H HB3  . GLN A 1 69  ? -7.05469  -45.21198 4.24022   1.000 43.66077  ? 69  GLN A HB3  1 
ATOM   1063 H HG2  . GLN A 1 69  ? -5.64556  -46.80877 5.10404   1.000 50.42312  ? 69  GLN A HG2  1 
ATOM   1064 H HG3  . GLN A 1 69  ? -6.14228  -47.86100 4.02168   1.000 50.42312  ? 69  GLN A HG3  1 
ATOM   1065 H HE21 . GLN A 1 69  ? -3.53294  -46.47071 4.61144   1.000 53.35077  ? 69  GLN A HE21 1 
ATOM   1066 H HE22 . GLN A 1 69  ? -3.00853  -46.05557 3.28048   1.000 53.35077  ? 69  GLN A HE22 1 
ATOM   1067 N N    . ALA A 1 70  ? -7.95675  -47.16513 7.21091   1.000 32.88658  ? 70  ALA A N    1 
ATOM   1068 C CA   . ALA A 1 70  ? -7.67346  -46.93463 8.62459   1.000 35.18518  ? 70  ALA A CA   1 
ATOM   1069 C C    . ALA A 1 70  ? -6.21860  -47.32160 8.86181   1.000 37.02755  ? 70  ALA A C    1 
ATOM   1070 O O    . ALA A 1 70  ? -5.87516  -48.50965 8.84176   1.000 36.28441  ? 70  ALA A O    1 
ATOM   1071 C CB   . ALA A 1 70  ? -8.61786  -47.74188 9.51227   1.000 35.10053  ? 70  ALA A CB   1 
ATOM   1072 H H    . ALA A 1 70  ? -7.94666  -47.99858 6.99911   1.000 39.45094  ? 70  ALA A H    1 
ATOM   1073 H HA   . ALA A 1 70  ? -7.79260  -45.99676 8.84160   1.000 42.20926  ? 70  ALA A HA   1 
ATOM   1074 H HB1  . ALA A 1 70  ? -8.42399  -47.54385 10.44184  1.000 42.10768  ? 70  ALA A HB1  1 
ATOM   1075 H HB2  . ALA A 1 70  ? -9.53308  -47.49582 9.30557   1.000 42.10768  ? 70  ALA A HB2  1 
ATOM   1076 H HB3  . ALA A 1 70  ? -8.48248  -48.68685 9.34018   1.000 42.10768  ? 70  ALA A HB3  1 
ATOM   1077 N N    . GLY A 1 71  ? -5.36969  -46.32594 9.08168   1.000 32.93128  ? 71  GLY A N    1 
ATOM   1078 C CA   . GLY A 1 71  ? -3.94329  -46.59055 9.06229   1.000 37.17369  ? 71  GLY A CA   1 
ATOM   1079 C C    . GLY A 1 71  ? -3.52466  -47.02661 7.67393   1.000 37.84106  ? 71  GLY A C    1 
ATOM   1080 O O    . GLY A 1 71  ? -3.91830  -46.43147 6.66401   1.000 41.48701  ? 71  GLY A O    1 
ATOM   1081 H H    . GLY A 1 71  ? -5.58924  -45.50970 9.24029   1.000 39.50458  ? 71  GLY A H    1 
ATOM   1082 H HA2  . GLY A 1 71  ? -3.45360  -45.78876 9.30361   1.000 44.59547  ? 71  GLY A HA2  1 
ATOM   1083 H HA3  . GLY A 1 71  ? -3.72761  -47.29443 9.69390   1.000 44.59547  ? 71  GLY A HA3  1 
ATOM   1084 N N    . ASN A 1 72  ? -2.72231  -48.08568 7.61181   1.000 39.52683  ? 72  ASN A N    1 
ATOM   1085 C CA   . ASN A 1 72  ? -2.33233  -48.69254 6.34774   1.000 42.19425  ? 72  ASN A CA   1 
ATOM   1086 C C    . ASN A 1 72  ? -3.26646  -49.82430 5.93471   1.000 42.95808  ? 72  ASN A C    1 
ATOM   1087 O O    . ASN A 1 72  ? -2.89621  -50.63977 5.08259   1.000 45.83124  ? 72  ASN A O    1 
ATOM   1088 C CB   . ASN A 1 72  ? -0.89554  -49.21486 6.43313   1.000 44.61733  ? 72  ASN A CB   1 
ATOM   1089 H H    . ASN A 1 72  ? -2.38667  -48.47531 8.30111   1.000 47.41925  ? 72  ASN A H    1 
ATOM   1090 H HA   . ASN A 1 72  ? -2.36274  -48.00885 5.66032   1.000 50.62015  ? 72  ASN A HA   1 
ATOM   1091 N N    . VAL A 1 73  ? -4.46304  -49.89098 6.51839   1.000 39.65921  ? 73  VAL A N    1 
ATOM   1092 C CA   . VAL A 1 73  ? -5.37063  -51.02065 6.35746   1.000 38.39048  ? 73  VAL A CA   1 
ATOM   1093 C C    . VAL A 1 73  ? -6.64098  -50.54279 5.66770   1.000 37.80472  ? 73  VAL A C    1 
ATOM   1094 O O    . VAL A 1 73  ? -7.24906  -49.55126 6.08811   1.000 33.28003  ? 73  VAL A O    1 
ATOM   1095 C CB   . VAL A 1 73  ? -5.69597  -51.67189 7.71443   1.000 38.44720  ? 73  VAL A CB   1 
ATOM   1096 C CG1  . VAL A 1 73  ? -6.86653  -52.63150 7.58321   1.000 35.47142  ? 73  VAL A CG1  1 
ATOM   1097 C CG2  . VAL A 1 73  ? -4.46364  -52.38489 8.26040   1.000 38.83723  ? 73  VAL A CG2  1 
ATOM   1098 H H    . VAL A 1 73  ? -4.77815  -49.27350 7.02733   1.000 47.57810  ? 73  VAL A H    1 
ATOM   1099 H HA   . VAL A 1 73  ? -4.95485  -51.68284 5.78341   1.000 46.05562  ? 73  VAL A HA   1 
ATOM   1100 H HB   . VAL A 1 73  ? -5.95272  -50.98146 8.34553   1.000 46.12369  ? 73  VAL A HB   1 
ATOM   1101 H HG11 . VAL A 1 73  ? -6.87794  -52.99459 6.68380   1.000 42.55275  ? 73  VAL A HG11 1 
ATOM   1102 H HG12 . VAL A 1 73  ? -6.76099  -53.34841 8.22803   1.000 42.55275  ? 73  VAL A HG12 1 
ATOM   1103 H HG13 . VAL A 1 73  ? -7.69061  -52.14988 7.75597   1.000 42.55275  ? 73  VAL A HG13 1 
ATOM   1104 H HG21 . VAL A 1 73  ? -4.71910  -52.90734 9.03672   1.000 46.59173  ? 73  VAL A HG21 1 
ATOM   1105 H HG22 . VAL A 1 73  ? -4.10543  -52.96773 7.57273   1.000 46.59173  ? 73  VAL A HG22 1 
ATOM   1106 H HG23 . VAL A 1 73  ? -3.80070  -51.72259 8.51097   1.000 46.59173  ? 73  VAL A HG23 1 
ATOM   1107 N N    . GLN A 1 74  ? -7.04731  -51.26333 4.62226   1.000 36.37898  ? 74  GLN A N    1 
ATOM   1108 C CA   . GLN A 1 74  ? -8.23041  -50.92412 3.84325   1.000 34.79038  ? 74  GLN A CA   1 
ATOM   1109 C C    . GLN A 1 74  ? -9.46555  -51.58305 4.44525   1.000 33.82807  ? 74  GLN A C    1 
ATOM   1110 O O    . GLN A 1 74  ? -9.44812  -52.77701 4.75934   1.000 33.72197  ? 74  GLN A O    1 
ATOM   1111 C CB   . GLN A 1 74  ? -8.05833  -51.37778 2.39278   1.000 37.72985  ? 74  GLN A CB   1 
ATOM   1112 C CG   . GLN A 1 74  ? -8.87304  -50.58173 1.38871   1.000 41.40240  ? 74  GLN A CG   1 
ATOM   1113 C CD   . GLN A 1 74  ? -8.26621  -49.21782 1.10776   1.000 46.64174  ? 74  GLN A CD   1 
ATOM   1114 O OE1  . GLN A 1 74  ? -7.07814  -48.99464 1.34137   1.000 46.55302  ? 74  GLN A OE1  1 
ATOM   1115 N NE2  . GLN A 1 74  ? -9.07906  -48.29903 0.60457   1.000 46.19206  ? 74  GLN A NE2  1 
ATOM   1116 H H    . GLN A 1 74  ? -6.64336  -51.96840 4.34064   1.000 43.64182  ? 74  GLN A H    1 
ATOM   1117 H HA   . GLN A 1 74  ? -8.35815  -49.96274 3.86101   1.000 41.73550  ? 74  GLN A HA   1 
ATOM   1118 H HB2  . GLN A 1 74  ? -7.12362  -51.28891 2.14925   1.000 45.26287  ? 74  GLN A HB2  1 
ATOM   1119 H HB3  . GLN A 1 74  ? -8.33235  -52.30572 2.32388   1.000 45.26287  ? 74  GLN A HB3  1 
ATOM   1120 H HG2  . GLN A 1 74  ? -8.91446  -51.07194 0.55271   1.000 49.66992  ? 74  GLN A HG2  1 
ATOM   1121 H HG3  . GLN A 1 74  ? -9.76743  -50.44796 1.73952   1.000 49.66992  ? 74  GLN A HG3  1 
ATOM   1122 H HE21 . GLN A 1 74  ? -8.78152  -47.51153 0.42878   1.000 55.41752  ? 74  GLN A HE21 1 
ATOM   1123 H HE22 . GLN A 1 74  ? -9.90382  -48.49061 0.45399   1.000 55.41752  ? 74  GLN A HE22 1 
ATOM   1124 N N    . LEU A 1 75  ? -10.53448 -50.80819 4.59624   1.000 31.94490  ? 75  LEU A N    1 
ATOM   1125 C CA   . LEU A 1 75  ? -11.81237 -51.32226 5.06693   1.000 33.46616  ? 75  LEU A CA   1 
ATOM   1126 C C    . LEU A 1 75  ? -12.72727 -51.59849 3.87893   1.000 33.38829  ? 75  LEU A C    1 
ATOM   1127 O O    . LEU A 1 75  ? -12.68577 -50.90012 2.86181   1.000 33.93832  ? 75  LEU A O    1 
ATOM   1128 C CB   . LEU A 1 75  ? -12.49536 -50.33895 6.02100   1.000 33.30545  ? 75  LEU A CB   1 
ATOM   1129 C CG   . LEU A 1 75  ? -11.73386 -49.92197 7.28091   1.000 32.41747  ? 75  LEU A CG   1 
ATOM   1130 C CD1  . LEU A 1 75  ? -12.58647 -48.98485 8.12274   1.000 28.78629  ? 75  LEU A CD1  1 
ATOM   1131 C CD2  . LEU A 1 75  ? -11.30779 -51.13123 8.10064   1.000 36.16607  ? 75  LEU A CD2  1 
ATOM   1132 H H    . LEU A 1 75  ? -10.54289 -49.96470 4.42873   1.000 38.32093  ? 75  LEU A H    1 
ATOM   1133 H HA   . LEU A 1 75  ? -11.66386 -52.14958 5.55107   1.000 40.14643  ? 75  LEU A HA   1 
ATOM   1134 H HB2  . LEU A 1 75  ? -12.68074 -49.52639 5.52474   1.000 39.95359  ? 75  LEU A HB2  1 
ATOM   1135 H HB3  . LEU A 1 75  ? -13.32571 -50.74343 6.31736   1.000 39.95359  ? 75  LEU A HB3  1 
ATOM   1136 H HG   . LEU A 1 75  ? -10.92725 -49.45460 7.01289   1.000 38.88801  ? 75  LEU A HG   1 
ATOM   1137 H HD11 . LEU A 1 75  ? -12.03965 -48.61154 8.83163   1.000 34.53059  ? 75  LEU A HD11 1 
ATOM   1138 H HD12 . LEU A 1 75  ? -12.92611 -48.27349 7.55749   1.000 34.53059  ? 75  LEU A HD12 1 
ATOM   1139 H HD13 . LEU A 1 75  ? -13.32470 -49.48587 8.50342   1.000 34.53059  ? 75  LEU A HD13 1 
ATOM   1140 H HD21 . LEU A 1 75  ? -11.04744 -50.83596 8.98717   1.000 43.38633  ? 75  LEU A HD21 1 
ATOM   1141 H HD22 . LEU A 1 75  ? -12.05317 -51.74880 8.16331   1.000 43.38633  ? 75  LEU A HD22 1 
ATOM   1142 H HD23 . LEU A 1 75  ? -10.55750 -51.56179 7.66178   1.000 43.38633  ? 75  LEU A HD23 1 
ATOM   1143 N N    . ARG A 1 76  ? -13.56246 -52.62158 4.02087   1.000 31.53391  ? 76  ARG A N    1 
ATOM   1144 C CA   . ARG A 1 76  ? -14.46725 -53.03847 2.95776   1.000 32.64784  ? 76  ARG A CA   1 
ATOM   1145 C C    . ARG A 1 76  ? -15.81338 -52.34386 3.13684   1.000 31.98185  ? 76  ARG A C    1 
ATOM   1146 O O    . ARG A 1 76  ? -16.46157 -52.49782 4.17762   1.000 30.14716  ? 76  ARG A O    1 
ATOM   1147 C CB   . ARG A 1 76  ? -14.63345 -54.55845 2.96974   1.000 34.77850  ? 76  ARG A CB   1 
ATOM   1148 C CG   . ARG A 1 76  ? -15.45159 -55.11051 1.81354   1.000 35.79595  ? 76  ARG A CG   1 
ATOM   1149 C CD   . ARG A 1 76  ? -15.47567 -56.63482 1.83299   1.000 36.77471  ? 76  ARG A CD   1 
ATOM   1150 N NE   . ARG A 1 76  ? -14.14696 -57.19971 1.63118   1.000 40.48113  ? 76  ARG A NE   1 
ATOM   1151 C CZ   . ARG A 1 76  ? -13.57760 -57.37836 0.44642   1.000 42.23391  ? 76  ARG A CZ   1 
ATOM   1152 N NH1  . ARG A 1 76  ? -14.20052 -57.05768 -0.67742  1.000 38.00836  ? 76  ARG A NH1  1 
ATOM   1153 N NH2  . ARG A 1 76  ? -12.34988 -57.88538 0.38767   1.000 49.50757  ? 76  ARG A NH2  1 
ATOM   1154 H H    . ARG A 1 76  ? -13.62432 -53.09704 4.73481   1.000 37.82773  ? 76  ARG A H    1 
ATOM   1155 H HA   . ARG A 1 76  ? -14.10408 -52.77544 2.09764   1.000 39.16446  ? 76  ARG A HA   1 
ATOM   1156 H HB2  . ARG A 1 76  ? -13.75421 -54.96597 2.92776   1.000 41.72124  ? 76  ARG A HB2  1 
ATOM   1157 H HB3  . ARG A 1 76  ? -15.07876 -54.81432 3.79262   1.000 41.72124  ? 76  ARG A HB3  1 
ATOM   1158 H HG2  . ARG A 1 76  ? -16.36423 -54.78910 1.88199   1.000 42.94219  ? 76  ARG A HG2  1 
ATOM   1159 H HG3  . ARG A 1 76  ? -15.06006 -54.82129 0.97452   1.000 42.94219  ? 76  ARG A HG3  1 
ATOM   1160 H HD2  . ARG A 1 76  ? -15.80770 -56.93865 2.69227   1.000 44.11670  ? 76  ARG A HD2  1 
ATOM   1161 H HD3  . ARG A 1 76  ? -16.05303 -56.95481 1.12225   1.000 44.11670  ? 76  ARG A HD3  1 
ATOM   1162 H HE   . ARG A 1 76  ? -13.70132 -57.43336 2.32862   1.000 48.56440  ? 76  ARG A HE   1 
ATOM   1163 H HH11 . ARG A 1 76  ? -14.99312 -56.72506 -0.64991  1.000 45.59707  ? 76  ARG A HH11 1 
ATOM   1164 H HH12 . ARG A 1 76  ? -13.81243 -57.18204 -1.43474  1.000 45.59707  ? 76  ARG A HH12 1 
ATOM   1165 H HH21 . ARG A 1 76  ? -11.93525 -58.09292 1.11197   1.000 59.39614  ? 76  ARG A HH21 1 
ATOM   1166 H HH22 . ARG A 1 76  ? -11.97040 -58.00578 -0.37463  1.000 59.39614  ? 76  ARG A HH22 1 
ATOM   1167 N N    . VAL A 1 77  ? -16.23222 -51.59069 2.12266   1.000 29.19454  ? 77  VAL A N    1 
ATOM   1168 C CA   . VAL A 1 77  ? -17.48593 -50.84119 2.16339   1.000 30.42942  ? 77  VAL A CA   1 
ATOM   1169 C C    . VAL A 1 77  ? -18.59678 -51.73520 1.62460   1.000 32.26073  ? 77  VAL A C    1 
ATOM   1170 O O    . VAL A 1 77  ? -18.50589 -52.23932 0.49974   1.000 27.35337  ? 77  VAL A O    1 
ATOM   1171 C CB   . VAL A 1 77  ? -17.38045 -49.54134 1.35338   1.000 29.51583  ? 77  VAL A CB   1 
ATOM   1172 C CG1  . VAL A 1 77  ? -18.71290 -48.78927 1.34910   1.000 26.87680  ? 77  VAL A CG1  1 
ATOM   1173 C CG2  . VAL A 1 77  ? -16.26048 -48.66469 1.90290   1.000 30.42277  ? 77  VAL A CG2  1 
ATOM   1174 H H    . VAL A 1 77  ? -15.79948 -51.49572 1.38557   1.000 35.02049  ? 77  VAL A H    1 
ATOM   1175 H HA   . VAL A 1 77  ? -17.69515 -50.61275 3.08259   1.000 36.50235  ? 77  VAL A HA   1 
ATOM   1176 H HB   . VAL A 1 77  ? -17.16772 -49.76288 0.43329   1.000 35.40604  ? 77  VAL A HB   1 
ATOM   1177 H HG11 . VAL A 1 77  ? -18.56420 -47.88514 1.03078   1.000 32.23921  ? 77  VAL A HG11 1 
ATOM   1178 H HG12 . VAL A 1 77  ? -19.33310 -49.24893 0.76176   1.000 32.23921  ? 77  VAL A HG12 1 
ATOM   1179 H HG13 . VAL A 1 77  ? -19.06647 -48.76807 2.25212   1.000 32.23921  ? 77  VAL A HG13 1 
ATOM   1180 H HG21 . VAL A 1 77  ? -16.18602 -47.86740 1.35547   1.000 36.49437  ? 77  VAL A HG21 1 
ATOM   1181 H HG22 . VAL A 1 77  ? -16.47119 -48.41951 2.81744   1.000 36.49437  ? 77  VAL A HG22 1 
ATOM   1182 H HG23 . VAL A 1 77  ? -15.42833 -49.16245 1.87723   1.000 36.49437  ? 77  VAL A HG23 1 
ATOM   1183 N N    . ILE A 1 78  ? -19.64775 -51.92984 2.42575   1.000 29.60377  ? 78  ILE A N    1 
ATOM   1184 C CA   . ILE A 1 78  ? -20.72574 -52.85222 2.09750   1.000 29.04486  ? 78  ILE A CA   1 
ATOM   1185 C C    . ILE A 1 78  ? -22.07578 -52.15171 1.99445   1.000 29.56717  ? 78  ILE A C    1 
ATOM   1186 O O    . ILE A 1 78  ? -23.10485 -52.81535 1.87548   1.000 28.79896  ? 78  ILE A O    1 
ATOM   1187 C CB   . ILE A 1 78  ? -20.78717 -54.01072 3.11316   1.000 32.42372  ? 78  ILE A CB   1 
ATOM   1188 C CG1  . ILE A 1 78  ? -21.17565 -53.49932 4.50273   1.000 33.85627  ? 78  ILE A CG1  1 
ATOM   1189 C CG2  . ILE A 1 78  ? -19.43887 -54.71941 3.17337   1.000 37.25370  ? 78  ILE A CG2  1 
ATOM   1190 C CD1  . ILE A 1 78  ? -21.18015 -54.58273 5.57346   1.000 33.25298  ? 78  ILE A CD1  1 
ATOM   1191 H H    . ILE A 1 78  ? -19.75615 -51.52866 3.17868   1.000 35.51157  ? 78  ILE A H    1 
ATOM   1192 H HA   . ILE A 1 78  ? -20.53980 -53.22994 1.22362   1.000 34.84087  ? 78  ILE A HA   1 
ATOM   1193 H HB   . ILE A 1 78  ? -21.46729 -54.63679 2.81926   1.000 38.89551  ? 78  ILE A HB   1 
ATOM   1194 H HG12 . ILE A 1 78  ? -20.54084 -52.81765 4.77336   1.000 40.61456  ? 78  ILE A HG12 1 
ATOM   1195 H HG13 . ILE A 1 78  ? -22.06837 -53.12249 4.45849   1.000 40.61456  ? 78  ILE A HG13 1 
ATOM   1196 H HG21 . ILE A 1 78  ? -19.12708 -54.88231 2.26941   1.000 44.69148  ? 78  ILE A HG21 1 
ATOM   1197 H HG22 . ILE A 1 78  ? -18.80626 -54.15510 3.64482   1.000 44.69148  ? 78  ILE A HG22 1 
ATOM   1198 H HG23 . ILE A 1 78  ? -19.54531 -55.56127 3.64331   1.000 44.69148  ? 78  ILE A HG23 1 
ATOM   1199 H HD11 . ILE A 1 78  ? -21.62504 -54.24228 6.36533   1.000 39.89063  ? 78  ILE A HD11 1 
ATOM   1200 H HD12 . ILE A 1 78  ? -21.65413 -55.35867 5.23559   1.000 39.89063  ? 78  ILE A HD12 1 
ATOM   1201 H HD13 . ILE A 1 78  ? -20.26409 -54.82107 5.78540   1.000 39.89063  ? 78  ILE A HD13 1 
ATOM   1202 N N    . GLY A 1 79  ? -22.09181 -50.82645 2.02544   1.000 26.65101  ? 79  GLY A N    1 
ATOM   1203 C CA   . GLY A 1 79  ? -23.33282 -50.08366 1.89814   1.000 28.21589  ? 79  GLY A CA   1 
ATOM   1204 C C    . GLY A 1 79  ? -23.04356 -48.60600 2.03569   1.000 26.43250  ? 79  GLY A C    1 
ATOM   1205 O O    . GLY A 1 79  ? -22.00334 -48.20113 2.56633   1.000 27.16833  ? 79  GLY A O    1 
ATOM   1206 H H    . GLY A 1 79  ? -21.39413 -50.33250 2.11962   1.000 31.96826  ? 79  GLY A H    1 
ATOM   1207 H HA2  . GLY A 1 79  ? -23.73448 -50.25038 1.03109   1.000 33.84611  ? 79  GLY A HA2  1 
ATOM   1208 H HA3  . GLY A 1 79  ? -23.95558 -50.35235 2.59159   1.000 33.84611  ? 79  GLY A HA3  1 
ATOM   1209 N N    . HIS A 1 80  ? -23.97962 -47.80189 1.53973   1.000 28.02117  ? 80  HIS A N    1 
ATOM   1210 C CA   . HIS A 1 80  ? -23.79125 -46.36032 1.62501   1.000 28.57673  ? 80  HIS A CA   1 
ATOM   1211 C C    . HIS A 1 80  ? -25.13343 -45.65247 1.52414   1.000 32.53017  ? 80  HIS A C    1 
ATOM   1212 O O    . HIS A 1 80  ? -26.05813 -46.12927 0.86012   1.000 31.03914  ? 80  HIS A O    1 
ATOM   1213 C CB   . HIS A 1 80  ? -22.82770 -45.85830 0.54123   1.000 29.70228  ? 80  HIS A CB   1 
ATOM   1214 C CG   . HIS A 1 80  ? -23.38115 -45.91847 -0.84882  1.000 32.80222  ? 80  HIS A CG   1 
ATOM   1215 N ND1  . HIS A 1 80  ? -23.19350 -47.00249 -1.68103  1.000 32.81576  ? 80  HIS A ND1  1 
ATOM   1216 C CD2  . HIS A 1 80  ? -24.10044 -45.01880 -1.56065  1.000 33.81896  ? 80  HIS A CD2  1 
ATOM   1217 C CE1  . HIS A 1 80  ? -23.78190 -46.77098 -2.84086  1.000 33.05131  ? 80  HIS A CE1  1 
ATOM   1218 N NE2  . HIS A 1 80  ? -24.33894 -45.57460 -2.79433  1.000 34.63233  ? 80  HIS A NE2  1 
ATOM   1219 H H    . HIS A 1 80  ? -24.70792 -48.05955 1.16186   1.000 33.61245  ? 80  HIS A H    1 
ATOM   1220 H HA   . HIS A 1 80  ? -23.41878 -46.14320 2.49393   1.000 34.27912  ? 80  HIS A HA   1 
ATOM   1221 H HB2  . HIS A 1 80  ? -22.60458 -44.93319 0.72909   1.000 35.62979  ? 80  HIS A HB2  1 
ATOM   1222 H HB3  . HIS A 1 80  ? -22.02591 -46.40382 0.56235   1.000 35.62979  ? 80  HIS A HB3  1 
ATOM   1223 H HD1  . HIS A 1 80  ? -22.76108 -47.71724 -1.47673  1.000 39.36596  ? 80  HIS A HD1  1 
ATOM   1224 H HD2  . HIS A 1 80  ? -24.38062 -44.18132 -1.26905  1.000 40.56980  ? 80  HIS A HD2  1 
ATOM   1225 H HE1  . HIS A 1 80  ? -23.80065 -47.35189 -3.56687  1.000 39.64862  ? 80  HIS A HE1  1 
ATOM   1226 N N    . SER A 1 81  ? -25.21382 -44.50192 2.19165   1.000 28.81522  ? 81  SER A N    1 
ATOM   1227 C CA   . SER A 1 81  ? -26.44405 -43.74011 2.33031   1.000 29.08845  ? 81  SER A CA   1 
ATOM   1228 C C    . SER A 1 81  ? -26.08341 -42.27649 2.52840   1.000 28.68737  ? 81  SER A C    1 
ATOM   1229 O O    . SER A 1 81  ? -25.04055 -41.95674 3.10522   1.000 30.72047  ? 81  SER A O    1 
ATOM   1230 C CB   . SER A 1 81  ? -27.27578 -44.23921 3.52093   1.000 27.38288  ? 81  SER A CB   1 
ATOM   1231 O OG   . SER A 1 81  ? -28.46905 -43.49384 3.66201   1.000 40.01161  ? 81  SER A OG   1 
ATOM   1232 H H    . SER A 1 81  ? -24.54441 -44.13236 2.58524   1.000 34.56531  ? 81  SER A H    1 
ATOM   1233 H HA   . SER A 1 81  ? -26.97821 -43.82384 1.52497   1.000 34.89318  ? 81  SER A HA   1 
ATOM   1234 H HB2  . SER A 1 81  ? -27.50292 -45.17113 3.37659   1.000 32.84650  ? 81  SER A HB2  1 
ATOM   1235 H HB3  . SER A 1 81  ? -26.75059 -44.14741 4.33127   1.000 32.84650  ? 81  SER A HB3  1 
ATOM   1236 H HG   . SER A 1 81  ? -28.30240 -42.74804 4.01073   1.000 48.00098  ? 81  SER A HG   1 
ATOM   1237 N N    . MET A 1 82  ? -26.95635 -41.38894 2.05986   1.000 27.63482  ? 82  MET A N    1 
ATOM   1238 C CA   . MET A 1 82  ? -26.79620 -39.95270 2.25971   1.000 28.78360  ? 82  MET A CA   1 
ATOM   1239 C C    . MET A 1 82  ? -27.82304 -39.49066 3.28418   1.000 26.85215  ? 82  MET A C    1 
ATOM   1240 O O    . MET A 1 82  ? -29.02661 -39.69269 3.09289   1.000 26.49439  ? 82  MET A O    1 
ATOM   1241 C CB   . MET A 1 82  ? -26.96027 -39.18114 0.94943   1.000 28.15093  ? 82  MET A CB   1 
ATOM   1242 C CG   . MET A 1 82  ? -26.67625 -37.68743 1.07428   1.000 25.49568  ? 82  MET A CG   1 
ATOM   1243 S SD   . MET A 1 82  ? -26.50134 -36.83932 -0.51661  1.000 29.44699  ? 82  MET A SD   1 
ATOM   1244 C CE   . MET A 1 82  ? -28.10755 -37.13765 -1.25296  1.000 31.98661  ? 82  MET A CE   1 
ATOM   1245 H H    . MET A 1 82  ? -27.66174 -41.59936 1.61518   1.000 33.14883  ? 82  MET A H    1 
ATOM   1246 H HA   . MET A 1 82  ? -25.90196 -39.77821 2.59257   1.000 34.52737  ? 82  MET A HA   1 
ATOM   1247 H HB2  . MET A 1 82  ? -26.34490 -39.54557 0.29414   1.000 33.76817  ? 82  MET A HB2  1 
ATOM   1248 H HB3  . MET A 1 82  ? -27.87376 -39.28375 0.63974   1.000 33.76817  ? 82  MET A HB3  1 
ATOM   1249 H HG2  . MET A 1 82  ? -27.40938 -37.26955 1.55261   1.000 30.58186  ? 82  MET A HG2  1 
ATOM   1250 H HG3  . MET A 1 82  ? -25.84844 -37.56742 1.56544   1.000 30.58186  ? 82  MET A HG3  1 
ATOM   1251 H HE1  . MET A 1 82  ? -28.21759 -38.09082 -1.39528  1.000 38.37097  ? 82  MET A HE1  1 
ATOM   1252 H HE2  . MET A 1 82  ? -28.79582 -36.81124 -0.65242  1.000 38.37097  ? 82  MET A HE2  1 
ATOM   1253 H HE3  . MET A 1 82  ? -28.15845 -36.66861 -2.10050  1.000 38.37097  ? 82  MET A HE3  1 
ATOM   1254 N N    . GLN A 1 83  ? -27.34631 -38.89344 4.37441   1.000 26.27902  ? 83  GLN A N    1 
ATOM   1255 C CA   . GLN A 1 83  ? -28.20583 -38.25253 5.36739   1.000 26.00757  ? 83  GLN A CA   1 
ATOM   1256 C C    . GLN A 1 83  ? -27.87048 -36.76882 5.37209   1.000 24.52620  ? 83  GLN A C    1 
ATOM   1257 O O    . GLN A 1 83  ? -26.80906 -36.36712 5.86091   1.000 23.51643  ? 83  GLN A O    1 
ATOM   1258 C CB   . GLN A 1 83  ? -28.02542 -38.86307 6.75543   1.000 29.31762  ? 83  GLN A CB   1 
ATOM   1259 C CG   . GLN A 1 83  ? -29.03198 -38.33553 7.76812   1.000 28.57423  ? 83  GLN A CG   1 
ATOM   1260 C CD   . GLN A 1 83  ? -28.87224 -38.93937 9.14944   1.000 31.70126  ? 83  GLN A CD   1 
ATOM   1261 O OE1  . GLN A 1 83  ? -27.85880 -39.56131 9.45970   1.000 31.99454  ? 83  GLN A OE1  1 
ATOM   1262 N NE2  . GLN A 1 83  ? -29.88063 -38.74902 9.99307   1.000 32.44008  ? 83  GLN A NE2  1 
ATOM   1263 H H    . GLN A 1 83  ? -26.50901 -38.84566 4.56479   1.000 31.52188  ? 83  GLN A H    1 
ATOM   1264 H HA   . GLN A 1 83  ? -29.13501 -38.37064 5.11527   1.000 31.19612  ? 83  GLN A HA   1 
ATOM   1265 H HB2  . GLN A 1 83  ? -28.13741 -39.82462 6.69399   1.000 35.16819  ? 83  GLN A HB2  1 
ATOM   1266 H HB3  . GLN A 1 83  ? -27.13559 -38.65272 7.07925   1.000 35.16819  ? 83  GLN A HB3  1 
ATOM   1267 H HG2  . GLN A 1 83  ? -28.92091 -37.37533 7.84924   1.000 34.27612  ? 83  GLN A HG2  1 
ATOM   1268 H HG3  . GLN A 1 83  ? -29.92722 -38.54076 7.45615   1.000 34.27612  ? 83  GLN A HG3  1 
ATOM   1269 H HE21 . GLN A 1 83  ? -30.57274 -38.30424 9.74255   1.000 38.91514  ? 83  GLN A HE21 1 
ATOM   1270 H HE22 . GLN A 1 83  ? -29.84133 -39.07057 10.78973  1.000 38.91514  ? 83  GLN A HE22 1 
ATOM   1271 N N    . ASN A 1 84  ? -28.77786 -35.95742 4.83652   1.000 27.11962  ? 84  ASN A N    1 
ATOM   1272 C CA   . ASN A 1 84  ? -28.50994 -34.53633 4.65156   1.000 25.56803  ? 84  ASN A CA   1 
ATOM   1273 C C    . ASN A 1 84  ? -27.15061 -34.36306 3.97680   1.000 24.79094  ? 84  ASN A C    1 
ATOM   1274 O O    . ASN A 1 84  ? -26.94237 -34.87718 2.87250   1.000 25.28279  ? 84  ASN A O    1 
ATOM   1275 C CB   . ASN A 1 84  ? -28.59648 -33.81231 5.99420   1.000 25.94988  ? 84  ASN A CB   1 
ATOM   1276 C CG   . ASN A 1 84  ? -29.90902 -34.08299 6.70932   1.000 27.18078  ? 84  ASN A CG   1 
ATOM   1277 O OD1  . ASN A 1 84  ? -30.97660 -33.69813 6.23130   1.000 26.81774  ? 84  ASN A OD1  1 
ATOM   1278 N ND2  . ASN A 1 84  ? -29.83844 -34.75764 7.85254   1.000 27.08559  ? 84  ASN A ND2  1 
ATOM   1279 H H    . ASN A 1 84  ? -29.55733 -36.20641 4.57189   1.000 32.53059  ? 84  ASN A H    1 
ATOM   1280 H HA   . ASN A 1 84  ? -29.17362 -34.12566 4.07555   1.000 30.66868  ? 84  ASN A HA   1 
ATOM   1281 H HB2  . ASN A 1 84  ? -27.87314 -34.11419 6.56565   1.000 31.12690  ? 84  ASN A HB2  1 
ATOM   1282 H HB3  . ASN A 1 84  ? -28.52492 -32.85647 5.84542   1.000 31.12690  ? 84  ASN A HB3  1 
ATOM   1283 H HD21 . ASN A 1 84  ? -30.55590 -34.93427 8.29260   1.000 32.48975  ? 84  ASN A HD21 1 
ATOM   1284 H HD22 . ASN A 1 84  ? -29.07532 -35.01747 8.15209   1.000 32.48975  ? 84  ASN A HD22 1 
ATOM   1285 N N    . CYS A 1 85  ? -26.20646 -33.68305 4.62699   1.000 23.80002  ? 85  CYS A N    1 
ATOM   1286 C CA   . CYS A 1 85  ? -24.94889 -33.32156 3.98677   1.000 22.84212  ? 85  CYS A CA   1 
ATOM   1287 C C    . CYS A 1 85  ? -23.79428 -34.26528 4.32968   1.000 24.31260  ? 85  CYS A C    1 
ATOM   1288 O O    . CYS A 1 85  ? -22.63650 -33.91389 4.08845   1.000 22.18523  ? 85  CYS A O    1 
ATOM   1289 C CB   . CYS A 1 85  ? -24.56732 -31.88519 4.35096   1.000 26.07428  ? 85  CYS A CB   1 
ATOM   1290 S SG   . CYS A 1 85  ? -25.71000 -30.63379 3.72770   1.000 23.19269  ? 85  CYS A SG   1 
ATOM   1291 H H    . CYS A 1 85  ? -26.27457 -33.42030 5.44303   1.000 28.54708  ? 85  CYS A H    1 
ATOM   1292 H HA   . CYS A 1 85  ? -25.08620 -33.37416 3.02798   1.000 27.39759  ? 85  CYS A HA   1 
ATOM   1293 H HB2  . CYS A 1 85  ? -24.54353 -31.80653 5.31747   1.000 31.27618  ? 85  CYS A HB2  1 
ATOM   1294 H HB3  . CYS A 1 85  ? -23.69131 -31.69403 3.98089   1.000 31.27618  ? 85  CYS A HB3  1 
ATOM   1295 H HG   . CYS A 1 85  ? -25.63177 -30.59474 2.53089   1.000 27.81827  ? 85  CYS A HG   1 
ATOM   1296 N N    . VAL A 1 86  ? -24.07285 -35.45329 4.87504   1.000 23.81723  ? 86  VAL A N    1 
ATOM   1297 C CA   . VAL A 1 86  ? -23.02266 -36.42946 5.14543   1.000 24.18946  ? 86  VAL A CA   1 
ATOM   1298 C C    . VAL A 1 86  ? -23.38792 -37.76710 4.52114   1.000 25.80079  ? 86  VAL A C    1 
ATOM   1299 O O    . VAL A 1 86  ? -24.56506 -38.08689 4.32194   1.000 26.88345  ? 86  VAL A O    1 
ATOM   1300 C CB   . VAL A 1 86  ? -22.74759 -36.61843 6.65772   1.000 25.80959  ? 86  VAL A CB   1 
ATOM   1301 C CG1  . VAL A 1 86  ? -22.26991 -35.31236 7.28789   1.000 24.90412  ? 86  VAL A CG1  1 
ATOM   1302 C CG2  . VAL A 1 86  ? -23.97513 -37.16191 7.36732   1.000 26.42657  ? 86  VAL A CG2  1 
ATOM   1303 H H    . VAL A 1 86  ? -24.86264 -35.71266 5.09539   1.000 28.56772  ? 86  VAL A H    1 
ATOM   1304 H HA   . VAL A 1 86  ? -22.21162 -36.10412 4.72441   1.000 29.01440  ? 86  VAL A HA   1 
ATOM   1305 H HB   . VAL A 1 86  ? -22.03818 -37.27102 6.76621   1.000 30.95855  ? 86  VAL A HB   1 
ATOM   1306 H HG11 . VAL A 1 86  ? -22.35364 -35.37776 8.25205   1.000 29.87199  ? 86  VAL A HG11 1 
ATOM   1307 H HG12 . VAL A 1 86  ? -21.34219 -35.16560 7.04563   1.000 29.87199  ? 86  VAL A HG12 1 
ATOM   1308 H HG13 . VAL A 1 86  ? -22.81750 -34.58327 6.95702   1.000 29.87199  ? 86  VAL A HG13 1 
ATOM   1309 H HG21 . VAL A 1 86  ? -23.83506 -37.10929 8.32571   1.000 31.69893  ? 86  VAL A HG21 1 
ATOM   1310 H HG22 . VAL A 1 86  ? -24.74646 -36.63010 7.11607   1.000 31.69893  ? 86  VAL A HG22 1 
ATOM   1311 H HG23 . VAL A 1 86  ? -24.10975 -38.08541 7.10291   1.000 31.69893  ? 86  VAL A HG23 1 
ATOM   1312 N N    . LEU A 1 87  ? -22.35771 -38.55031 4.21121   1.000 24.10983  ? 87  LEU A N    1 
ATOM   1313 C CA   . LEU A 1 87  ? -22.51297 -39.92953 3.78089   1.000 25.40710  ? 87  LEU A CA   1 
ATOM   1314 C C    . LEU A 1 87  ? -22.26589 -40.86157 4.95796   1.000 27.23686  ? 87  LEU A C    1 
ATOM   1315 O O    . LEU A 1 87  ? -21.42795 -40.58929 5.81963   1.000 23.39556  ? 87  LEU A O    1 
ATOM   1316 C CB   . LEU A 1 87  ? -21.54067 -40.27923 2.65498   1.000 25.25459  ? 87  LEU A CB   1 
ATOM   1317 C CG   . LEU A 1 87  ? -21.64779 -39.43652 1.39114   1.000 27.96471  ? 87  LEU A CG   1 
ATOM   1318 C CD1  . LEU A 1 87  ? -20.71284 -39.97217 0.31178   1.000 27.38801  ? 87  LEU A CD1  1 
ATOM   1319 C CD2  . LEU A 1 87  ? -23.08377 -39.37515 0.89763   1.000 30.06655  ? 87  LEU A CD2  1 
ATOM   1320 H H    . LEU A 1 87  ? -21.53726 -38.29467 4.24456   1.000 28.91885  ? 87  LEU A H    1 
ATOM   1321 H HA   . LEU A 1 87  ? -23.41496 -40.05879 3.44830   1.000 30.47556  ? 87  LEU A HA   1 
ATOM   1322 H HB2  . LEU A 1 87  ? -20.63739 -40.17560 2.99299   1.000 30.29255  ? 87  LEU A HB2  1 
ATOM   1323 H HB3  . LEU A 1 87  ? -21.69506 -41.20184 2.39836   1.000 30.29255  ? 87  LEU A HB3  1 
ATOM   1324 H HG   . LEU A 1 87  ? -21.37531 -38.52791 1.59384   1.000 33.54470  ? 87  LEU A HG   1 
ATOM   1325 H HD11 . LEU A 1 87  ? -20.92229 -40.90484 0.14697   1.000 32.85266  ? 87  LEU A HD11 1 
ATOM   1326 H HD12 . LEU A 1 87  ? -20.83923 -39.45634 -0.49992  1.000 32.85266  ? 87  LEU A HD12 1 
ATOM   1327 H HD13 . LEU A 1 87  ? -19.79623 -39.88807 0.61779   1.000 32.85266  ? 87  LEU A HD13 1 
ATOM   1328 H HD21 . LEU A 1 87  ? -23.48064 -40.25725 0.97031   1.000 36.06691  ? 87  LEU A HD21 1 
ATOM   1329 H HD22 . LEU A 1 87  ? -23.57849 -38.74388 1.44320   1.000 36.06691  ? 87  LEU A HD22 1 
ATOM   1330 H HD23 . LEU A 1 87  ? -23.08740 -39.08606 -0.02828  1.000 36.06691  ? 87  LEU A HD23 1 
ATOM   1331 N N    . LYS A 1 88  ? -23.00332 -41.96460 4.98339   1.000 27.67539  ? 88  LYS A N    1 
ATOM   1332 C CA   . LYS A 1 88  ? -22.78061 -43.04204 5.93913   1.000 26.50214  ? 88  LYS A CA   1 
ATOM   1333 C C    . LYS A 1 88  ? -22.33862 -44.26575 5.14938   1.000 26.65603  ? 88  LYS A C    1 
ATOM   1334 O O    . LYS A 1 88  ? -23.14141 -44.86583 4.42767   1.000 26.51544  ? 88  LYS A O    1 
ATOM   1335 C CB   . LYS A 1 88  ? -24.04031 -43.32971 6.75096   1.000 27.94660  ? 88  LYS A CB   1 
ATOM   1336 C CG   . LYS A 1 88  ? -24.57194 -42.11599 7.48341   1.000 31.06106  ? 88  LYS A CG   1 
ATOM   1337 C CD   . LYS A 1 88  ? -25.53655 -42.51069 8.58939   1.000 36.10733  ? 88  LYS A CD   1 
ATOM   1338 C CE   . LYS A 1 88  ? -26.97628 -42.23976 8.20131   1.000 39.38023  ? 88  LYS A CE   1 
ATOM   1339 N NZ   . LYS A 1 88  ? -27.91635 -42.67852 9.26892   1.000 46.23937  ? 88  LYS A NZ   1 
ATOM   1340 H H    . LYS A 1 88  ? -23.65513 -42.11546 4.44303   1.000 33.19751  ? 88  LYS A H    1 
ATOM   1341 H HA   . LYS A 1 88  ? -22.07837 -42.79353 6.56042   1.000 31.78961  ? 88  LYS A HA   1 
ATOM   1342 H HB2  . LYS A 1 88  ? -24.73493 -43.64359 6.15106   1.000 33.52296  ? 88  LYS A HB2  1 
ATOM   1343 H HB3  . LYS A 1 88  ? -23.83896 -44.01145 7.41095   1.000 33.52296  ? 88  LYS A HB3  1 
ATOM   1344 H HG2  . LYS A 1 88  ? -23.83207 -41.63210 7.88260   1.000 37.26031  ? 88  LYS A HG2  1 
ATOM   1345 H HG3  . LYS A 1 88  ? -25.04330 -41.54407 6.85760   1.000 37.26031  ? 88  LYS A HG3  1 
ATOM   1346 H HD2  . LYS A 1 88  ? -25.44427 -43.45890 8.77179   1.000 43.31584  ? 88  LYS A HD2  1 
ATOM   1347 H HD3  . LYS A 1 88  ? -25.33548 -41.99812 9.38798   1.000 43.31584  ? 88  LYS A HD3  1 
ATOM   1348 H HE2  . LYS A 1 88  ? -27.09762 -41.28792 8.05925   1.000 47.24332  ? 88  LYS A HE2  1 
ATOM   1349 H HE3  . LYS A 1 88  ? -27.18758 -42.72602 7.38903   1.000 47.24332  ? 88  LYS A HE3  1 
ATOM   1350 H HZ1  . LYS A 1 88  ? -28.74820 -42.44288 9.05772   1.000 55.47429  ? 88  LYS A HZ1  1 
ATOM   1351 H HZ2  . LYS A 1 88  ? -27.88122 -43.56307 9.36077   1.000 55.47429  ? 88  LYS A HZ2  1 
ATOM   1352 H HZ3  . LYS A 1 88  ? -27.69632 -42.29876 10.04317  1.000 55.47429  ? 88  LYS A HZ3  1 
ATOM   1353 N N    . LEU A 1 89  ? -21.06302 -44.62362 5.27521   1.000 24.84012  ? 89  LEU A N    1 
ATOM   1354 C CA   . LEU A 1 89  ? -20.50100 -45.78626 4.60033   1.000 26.32905  ? 89  LEU A CA   1 
ATOM   1355 C C    . LEU A 1 89  ? -20.49310 -46.95552 5.57782   1.000 24.97320  ? 89  LEU A C    1 
ATOM   1356 O O    . LEU A 1 89  ? -19.71965 -46.96350 6.54219   1.000 26.93326  ? 89  LEU A O    1 
ATOM   1357 C CB   . LEU A 1 89  ? -19.09248 -45.49475 4.08865   1.000 25.29605  ? 89  LEU A CB   1 
ATOM   1358 C CG   . LEU A 1 89  ? -18.88113 -44.14695 3.39776   1.000 21.77083  ? 89  LEU A CG   1 
ATOM   1359 C CD1  . LEU A 1 89  ? -17.41448 -43.95028 3.05718   1.000 27.01488  ? 89  LEU A CD1  1 
ATOM   1360 C CD2  . LEU A 1 89  ? -19.73951 -44.03292 2.15289   1.000 27.33807  ? 89  LEU A CD2  1 
ATOM   1361 H H    . LEU A 1 89  ? -20.49226 -44.19775 5.75736   1.000 29.79519  ? 89  LEU A H    1 
ATOM   1362 H HA   . LEU A 1 89  ? -21.06058 -46.01693 3.84233   1.000 31.58191  ? 89  LEU A HA   1 
ATOM   1363 H HB2  . LEU A 1 89  ? -18.48604 -45.52518 4.84509   1.000 30.34231  ? 89  LEU A HB2  1 
ATOM   1364 H HB3  . LEU A 1 89  ? -18.85761 -46.18346 3.44723   1.000 30.34231  ? 89  LEU A HB3  1 
ATOM   1365 H HG   . LEU A 1 89  ? -19.14951 -43.43982 4.00508   1.000 26.11204  ? 89  LEU A HG   1 
ATOM   1366 H HD11 . LEU A 1 89  ? -17.25619 -44.26035 2.15181   1.000 32.40490  ? 89  LEU A HD11 1 
ATOM   1367 H HD12 . LEU A 1 89  ? -17.19787 -43.00732 3.12650   1.000 32.40490  ? 89  LEU A HD12 1 
ATOM   1368 H HD13 . LEU A 1 89  ? -16.87431 -44.46046 3.68074   1.000 32.40490  ? 89  LEU A HD13 1 
ATOM   1369 H HD21 . LEU A 1 89  ? -20.67232 -43.98955 2.41537   1.000 32.79274  ? 89  LEU A HD21 1 
ATOM   1370 H HD22 . LEU A 1 89  ? -19.49333 -43.22714 1.67226   1.000 32.79274  ? 89  LEU A HD22 1 
ATOM   1371 H HD23 . LEU A 1 89  ? -19.58918 -44.81083 1.59329   1.000 32.79274  ? 89  LEU A HD23 1 
ATOM   1372 N N    . LYS A 1 90  ? -21.35358 -47.93589 5.33191   1.000 23.40297  ? 90  LYS A N    1 
ATOM   1373 C CA   . LYS A 1 90  ? -21.34704 -49.15622 6.12424   1.000 24.47866  ? 90  LYS A CA   1 
ATOM   1374 C C    . LYS A 1 90  ? -20.14347 -50.00598 5.73443   1.000 27.93102  ? 90  LYS A C    1 
ATOM   1375 O O    . LYS A 1 90  ? -19.93000 -50.28869 4.55137   1.000 25.43639  ? 90  LYS A O    1 
ATOM   1376 C CB   . LYS A 1 90  ? -22.64873 -49.92767 5.90813   1.000 26.95564  ? 90  LYS A CB   1 
ATOM   1377 C CG   . LYS A 1 90  ? -22.77781 -51.22531 6.70800   1.000 29.82534  ? 90  LYS A CG   1 
ATOM   1378 C CD   . LYS A 1 90  ? -23.62565 -51.04140 7.96058   1.000 35.65883  ? 90  LYS A CD   1 
ATOM   1379 C CE   . LYS A 1 90  ? -23.99995 -52.38150 8.58770   1.000 40.77019  ? 90  LYS A CE   1 
ATOM   1380 N NZ   . LYS A 1 90  ? -24.84351 -53.21223 7.67976   1.000 46.50997  ? 90  LYS A NZ   1 
ATOM   1381 H H    . LYS A 1 90  ? -21.95021 -47.91879 4.71277   1.000 28.07061  ? 90  LYS A H    1 
ATOM   1382 H HA   . LYS A 1 90  ? -21.28201 -48.94366 7.06842   1.000 29.36144  ? 90  LYS A HA   1 
ATOM   1383 H HB2  . LYS A 1 90  ? -23.38953 -49.35545 6.16247   1.000 32.33381  ? 90  LYS A HB2  1 
ATOM   1384 H HB3  . LYS A 1 90  ? -22.71533 -50.15855 4.96837   1.000 32.33381  ? 90  LYS A HB3  1 
ATOM   1385 H HG2  . LYS A 1 90  ? -23.19853 -51.90145 6.15416   1.000 35.77746  ? 90  LYS A HG2  1 
ATOM   1386 H HG3  . LYS A 1 90  ? -21.89532 -51.52171 6.98052   1.000 35.77746  ? 90  LYS A HG3  1 
ATOM   1387 H HD2  . LYS A 1 90  ? -23.12518 -50.52858 8.61438   1.000 42.77765  ? 90  LYS A HD2  1 
ATOM   1388 H HD3  . LYS A 1 90  ? -24.44379 -50.57477 7.72863   1.000 42.77765  ? 90  LYS A HD3  1 
ATOM   1389 H HE2  . LYS A 1 90  ? -23.19034 -52.87761 8.78597   1.000 48.91128  ? 90  LYS A HE2  1 
ATOM   1390 H HE3  . LYS A 1 90  ? -24.49998 -52.22278 9.40359   1.000 48.91128  ? 90  LYS A HE3  1 
ATOM   1391 H HZ1  . LYS A 1 90  ? -25.36380 -52.68795 7.18326   1.000 55.79901  ? 90  LYS A HZ1  1 
ATOM   1392 H HZ2  . LYS A 1 90  ? -24.32580 -53.69751 7.14257   1.000 55.79901  ? 90  LYS A HZ2  1 
ATOM   1393 H HZ3  . LYS A 1 90  ? -25.35723 -53.75970 8.15775   1.000 55.79901  ? 90  LYS A HZ3  1 
ATOM   1394 N N    . VAL A 1 91  ? -19.34612 -50.39932 6.72734   1.000 26.95257  ? 91  VAL A N    1 
ATOM   1395 C CA   . VAL A 1 91  ? -18.18412 -51.24803 6.50430   1.000 27.68880  ? 91  VAL A CA   1 
ATOM   1396 C C    . VAL A 1 91  ? -18.40471 -52.57618 7.21723   1.000 28.51284  ? 91  VAL A C    1 
ATOM   1397 O O    . VAL A 1 91  ? -19.27143 -52.71070 8.08332   1.000 29.29450  ? 91  VAL A O    1 
ATOM   1398 C CB   . VAL A 1 91  ? -16.87501 -50.58208 6.97562   1.000 29.21012  ? 91  VAL A CB   1 
ATOM   1399 C CG1  . VAL A 1 91  ? -16.55507 -49.36857 6.10266   1.000 30.60142  ? 91  VAL A CG1  1 
ATOM   1400 C CG2  . VAL A 1 91  ? -16.96895 -50.17607 8.44375   1.000 25.74495  ? 91  VAL A CG2  1 
ATOM   1401 H H    . VAL A 1 91  ? -19.46235 -50.18218 7.55131   1.000 32.33013  ? 91  VAL A H    1 
ATOM   1402 H HA   . VAL A 1 91  ? -18.10133 -51.42853 5.55484   1.000 33.21361  ? 91  VAL A HA   1 
ATOM   1403 H HB   . VAL A 1 91  ? -16.15129 -51.22227 6.89030   1.000 35.03919  ? 91  VAL A HB   1 
ATOM   1404 H HG11 . VAL A 1 91  ? -15.84780 -48.85480 6.52304   1.000 36.70875  ? 91  VAL A HG11 1 
ATOM   1405 H HG12 . VAL A 1 91  ? -16.26649 -49.67539 5.22888   1.000 36.70875  ? 91  VAL A HG12 1 
ATOM   1406 H HG13 . VAL A 1 91  ? -17.35262 -48.82347 6.01506   1.000 36.70875  ? 91  VAL A HG13 1 
ATOM   1407 H HG21 . VAL A 1 91  ? -17.62746 -49.46966 8.53454   1.000 30.88099  ? 91  VAL A HG21 1 
ATOM   1408 H HG22 . VAL A 1 91  ? -17.23645 -50.94703 8.96812   1.000 30.88099  ? 91  VAL A HG22 1 
ATOM   1409 H HG23 . VAL A 1 91  ? -16.10124 -49.85947 8.73999   1.000 30.88099  ? 91  VAL A HG23 1 
ATOM   1410 N N    . ASP A 1 92  ? -17.60267 -53.57005 6.83622   1.000 31.11957  ? 92  ASP A N    1 
ATOM   1411 C CA   . ASP A 1 92  ? -17.77713 -54.92665 7.34247   1.000 31.54888  ? 92  ASP A CA   1 
ATOM   1412 C C    . ASP A 1 92  ? -17.10411 -55.15503 8.68890   1.000 30.95264  ? 92  ASP A C    1 
ATOM   1413 O O    . ASP A 1 92  ? -17.14864 -56.28065 9.19684   1.000 32.56407  ? 92  ASP A O    1 
ATOM   1414 C CB   . ASP A 1 92  ? -17.23912 -55.94352 6.32745   1.000 31.78084  ? 92  ASP A CB   1 
ATOM   1415 C CG   . ASP A 1 92  ? -15.72220 -55.93601 6.23345   1.000 33.70442  ? 92  ASP A CG   1 
ATOM   1416 O OD1  . ASP A 1 92  ? -15.08628 -55.00012 6.76639   1.000 34.21983  ? 92  ASP A OD1  1 
ATOM   1417 O OD2  . ASP A 1 92  ? -15.16299 -56.87282 5.62169   1.000 36.49492  ? 92  ASP A OD2  1 
ATOM   1418 H H    . ASP A 1 92  ? -16.94922 -53.48188 6.28411   1.000 37.33053  ? 92  ASP A H    1 
ATOM   1419 H HA   . ASP A 1 92  ? -18.72719 -55.08695 7.45462   1.000 37.84570  ? 92  ASP A HA   1 
ATOM   1420 H HB2  . ASP A 1 92  ? -17.51852 -56.83350 6.59347   1.000 38.12405  ? 92  ASP A HB2  1 
ATOM   1421 H HB3  . ASP A 1 92  ? -17.59483 -55.73252 5.45004   1.000 38.12405  ? 92  ASP A HB3  1 
ATOM   1422 N N    . THR A 1 93  ? -16.49356 -54.13073 9.27759   1.000 28.96639  ? 93  THR A N    1 
ATOM   1423 C CA   . THR A 1 93  ? -15.76407 -54.27028 10.52925  1.000 28.62717  ? 93  THR A CA   1 
ATOM   1424 C C    . THR A 1 93  ? -16.12842 -53.13109 11.46438  1.000 27.54252  ? 93  THR A C    1 
ATOM   1425 O O    . THR A 1 93  ? -16.01641 -51.95817 11.09161  1.000 26.17314  ? 93  THR A O    1 
ATOM   1426 C CB   . THR A 1 93  ? -14.25209 -54.28145 10.28594  1.000 30.21153  ? 93  THR A CB   1 
ATOM   1427 O OG1  . THR A 1 93  ? -13.89034 -55.47800 9.58810   1.000 33.73066  ? 93  THR A OG1  1 
ATOM   1428 C CG2  . THR A 1 93  ? -13.49293 -54.20809 11.59986  1.000 30.51251  ? 93  THR A CG2  1 
ATOM   1429 H H    . THR A 1 93  ? -16.48899 -53.33028 8.96318   1.000 34.74672  ? 93  THR A H    1 
ATOM   1430 H HA   . THR A 1 93  ? -16.01986 -55.10355 10.95485  1.000 34.33964  ? 93  THR A HA   1 
ATOM   1431 H HB   . THR A 1 93  ? -14.00451 -53.50911 9.75387   1.000 36.24088  ? 93  THR A HB   1 
ATOM   1432 H HG1  . THR A 1 93  ? -14.31770 -55.53030 8.86683   1.000 40.46383  ? 93  THR A HG1  1 
ATOM   1433 H HG21 . THR A 1 93  ? -13.43846 -53.28750 11.90060  1.000 36.60205  ? 93  THR A HG21 1 
ATOM   1434 H HG22 . THR A 1 93  ? -13.94842 -54.73372 12.27599  1.000 36.60205  ? 93  THR A HG22 1 
ATOM   1435 H HG23 . THR A 1 93  ? -12.59455 -54.55501 11.48376  1.000 36.60205  ? 93  THR A HG23 1 
ATOM   1436 N N    . ALA A 1 94  ? -16.56576 -53.47855 12.67172  1.000 26.52439  ? 94  ALA A N    1 
ATOM   1437 C CA   . ALA A 1 94  ? -16.81198 -52.47532 13.69451  1.000 25.46630  ? 94  ALA A CA   1 
ATOM   1438 C C    . ALA A 1 94  ? -15.48698 -51.96906 14.24647  1.000 27.21536  ? 94  ALA A C    1 
ATOM   1439 O O    . ALA A 1 94  ? -14.56750 -52.74965 14.51048  1.000 26.77552  ? 94  ALA A O    1 
ATOM   1440 C CB   . ALA A 1 94  ? -17.66710 -53.05738 14.81985  1.000 28.63750  ? 94  ALA A CB   1 
ATOM   1441 H H    . ALA A 1 94  ? -16.72635 -54.28596 12.92050  1.000 31.81631  ? 94  ALA A H    1 
ATOM   1442 H HA   . ALA A 1 94  ? -17.29752 -51.72732 13.31288  1.000 30.54661  ? 94  ALA A HA   1 
ATOM   1443 H HB1  . ALA A 1 94  ? -17.19586 -53.80464 15.22038  1.000 34.35204  ? 94  ALA A HB1  1 
ATOM   1444 H HB2  . ALA A 1 94  ? -17.82337 -52.36962 15.48578  1.000 34.35204  ? 94  ALA A HB2  1 
ATOM   1445 H HB3  . ALA A 1 94  ? -18.51209 -53.35864 14.45088  1.000 34.35204  ? 94  ALA A HB3  1 
ATOM   1446 N N    . ASN A 1 95  ? -15.38630 -50.65504 14.40909  1.000 24.39121  ? 95  ASN A N    1 
ATOM   1447 C CA   . ASN A 1 95  ? -14.15924 -50.05609 14.92044  1.000 27.47006  ? 95  ASN A CA   1 
ATOM   1448 C C    . ASN A 1 95  ? -13.90144 -50.57782 16.32942  1.000 27.64352  ? 95  ASN A C    1 
ATOM   1449 O O    . ASN A 1 95  ? -14.66669 -50.26907 17.25040  1.000 27.38415  ? 95  ASN A O    1 
ATOM   1450 C CB   . ASN A 1 95  ? -14.25799 -48.52719 14.92053  1.000 25.23125  ? 95  ASN A CB   1 
ATOM   1451 C CG   . ASN A 1 95  ? -12.98848 -47.85537 15.42021  1.000 27.02371  ? 95  ASN A CG   1 
ATOM   1452 O OD1  . ASN A 1 95  ? -11.99195 -48.51142 15.70396  1.000 24.52003  ? 95  ASN A OD1  1 
ATOM   1453 N ND2  . ASN A 1 95  ? -13.02337 -46.53123 15.52304  1.000 29.32566  ? 95  ASN A ND2  1 
ATOM   1454 H H    . ASN A 1 95  ? -16.01120 -50.09151 14.23152  1.000 29.25650  ? 95  ASN A H    1 
ATOM   1455 H HA   . ASN A 1 95  ? -13.41172 -50.30152 14.35310  1.000 32.95112  ? 95  ASN A HA   1 
ATOM   1456 H HB2  . ASN A 1 95  ? -14.42277 -48.22108 14.01497  1.000 30.26455  ? 95  ASN A HB2  1 
ATOM   1457 H HB3  . ASN A 1 95  ? -14.98785 -48.25767 15.49981  1.000 30.26455  ? 95  ASN A HB3  1 
ATOM   1458 H HD21 . ASN A 1 95  ? -12.33117 -46.10312 15.80086  1.000 35.17784  ? 95  ASN A HD21 1 
ATOM   1459 H HD22 . ASN A 1 95  ? -13.73815 -46.10222 15.31179  1.000 35.17784  ? 95  ASN A HD22 1 
ATOM   1460 N N    . PRO A 1 96  ? -12.84418 -51.36610 16.54407  1.000 28.47081  ? 96  PRO A N    1 
ATOM   1461 C CA   . PRO A 1 96  ? -12.58464 -51.87148 17.90170  1.000 28.52844  ? 96  PRO A CA   1 
ATOM   1462 C C    . PRO A 1 96  ? -12.28821 -50.77173 18.90151  1.000 28.68466  ? 96  PRO A C    1 
ATOM   1463 O O    . PRO A 1 96  ? -12.37841 -51.01270 20.11175  1.000 28.82687  ? 96  PRO A O    1 
ATOM   1464 C CB   . PRO A 1 96  ? -11.37944 -52.80196 17.70788  1.000 28.13469  ? 96  PRO A CB   1 
ATOM   1465 C CG   . PRO A 1 96  ? -10.71180 -52.30785 16.47703  1.000 29.23439  ? 96  PRO A CG   1 
ATOM   1466 C CD   . PRO A 1 96  ? -11.79265 -51.76836 15.59293  1.000 29.31753  ? 96  PRO A CD   1 
ATOM   1467 H HA   . PRO A 1 96  ? -13.33797 -52.39551 18.21598  1.000 34.22117  ? 96  PRO A HA   1 
ATOM   1468 H HB2  . PRO A 1 96  ? -10.78714 -52.73997 18.47354  1.000 33.74867  ? 96  PRO A HB2  1 
ATOM   1469 H HB3  . PRO A 1 96  ? -11.68231 -53.71663 17.59592  1.000 33.74867  ? 96  PRO A HB3  1 
ATOM   1470 H HG2  . PRO A 1 96  ? -10.08035 -51.60897 16.70886  1.000 35.06831  ? 96  PRO A HG2  1 
ATOM   1471 H HG3  . PRO A 1 96  ? -10.24979 -53.04142 16.04192  1.000 35.06831  ? 96  PRO A HG3  1 
ATOM   1472 H HD2  . PRO A 1 96  ? -11.47480 -51.00420 15.08702  1.000 35.16809  ? 96  PRO A HD2  1 
ATOM   1473 H HD3  . PRO A 1 96  ? -12.11817 -52.45398 14.98889  1.000 35.16809  ? 96  PRO A HD3  1 
ATOM   1474 N N    . LYS A 1 97  ? -11.94316 -49.57232 18.43527  1.000 26.29012  ? 97  LYS A N    1 
ATOM   1475 C CA   . LYS A 1 97  ? -11.64173 -48.44009 19.29709  1.000 27.33087  ? 97  LYS A CA   1 
ATOM   1476 C C    . LYS A 1 97  ? -12.84388 -47.53083 19.52295  1.000 28.10603  ? 97  LYS A C    1 
ATOM   1477 O O    . LYS A 1 97  ? -12.67772 -46.43312 20.06210  1.000 29.54362  ? 97  LYS A O    1 
ATOM   1478 C CB   . LYS A 1 97  ? -10.49285 -47.61922 18.70199  1.000 28.50054  ? 97  LYS A CB   1 
ATOM   1479 C CG   . LYS A 1 97  ? -9.19074  -48.38758 18.52873  1.000 28.50713  ? 97  LYS A CG   1 
ATOM   1480 C CD   . LYS A 1 97  ? -8.11178  -47.51232 17.89457  1.000 31.89850  ? 97  LYS A CD   1 
ATOM   1481 C CE   . LYS A 1 97  ? -6.75509  -48.20197 17.89392  1.000 35.16937  ? 97  LYS A CE   1 
ATOM   1482 N NZ   . LYS A 1 97  ? -5.74835  -47.44871 17.09570  1.000 46.67542  ? 97  LYS A NZ   1 
ATOM   1483 H H    . LYS A 1 97  ? -11.87590 -49.38823 17.59790  1.000 31.53519  ? 97  LYS A H    1 
ATOM   1484 H HA   . LYS A 1 97  ? -11.36078 -48.78498 20.15907  1.000 32.78409  ? 97  LYS A HA   1 
ATOM   1485 H HB2  . LYS A 1 97  ? -10.76280 -47.29944 17.82691  1.000 34.18769  ? 97  LYS A HB2  1 
ATOM   1486 H HB3  . LYS A 1 97  ? -10.31370 -46.86805 19.28897  1.000 34.18769  ? 97  LYS A HB3  1 
ATOM   1487 H HG2  . LYS A 1 97  ? -8.87352  -48.68389 19.39618  1.000 34.19561  ? 97  LYS A HG2  1 
ATOM   1488 H HG3  . LYS A 1 97  ? -9.34225  -49.15254 17.95186  1.000 34.19561  ? 97  LYS A HG3  1 
ATOM   1489 H HD2  . LYS A 1 97  ? -8.35496  -47.31927 16.97561  1.000 38.26524  ? 97  LYS A HD2  1 
ATOM   1490 H HD3  . LYS A 1 97  ? -8.03264  -46.68654 18.39729  1.000 38.26524  ? 97  LYS A HD3  1 
ATOM   1491 H HE2  . LYS A 1 97  ? -6.43049  -48.26923 18.80552  1.000 42.19029  ? 97  LYS A HE2  1 
ATOM   1492 H HE3  . LYS A 1 97  ? -6.84696  -49.08727 17.50830  1.000 42.19029  ? 97  LYS A HE3  1 
ATOM   1493 H HZ1  . LYS A 1 97  ? -4.95747  -47.85419 17.14260  1.000 55.99755  ? 97  LYS A HZ1  1 
ATOM   1494 H HZ2  . LYS A 1 97  ? -6.00280  -47.40959 16.24374  1.000 55.99755  ? 97  LYS A HZ2  1 
ATOM   1495 H HZ3  . LYS A 1 97  ? -5.66748  -46.62049 17.41131  1.000 55.99755  ? 97  LYS A HZ3  1 
ATOM   1496 N N    . THR A 1 98  ? -14.04027 -47.94965 19.12221  1.000 26.41146  ? 98  THR A N    1 
ATOM   1497 C CA   . THR A 1 98  ? -15.20994 -47.09666 19.27231  1.000 26.45362  ? 98  THR A CA   1 
ATOM   1498 C C    . THR A 1 98  ? -15.41781 -46.76098 20.74518  1.000 26.85758  ? 98  THR A C    1 
ATOM   1499 O O    . THR A 1 98  ? -15.58346 -47.68002 21.56296  1.000 28.08960  ? 98  THR A O    1 
ATOM   1500 C CB   . THR A 1 98  ? -16.46695 -47.76394 18.72331  1.000 27.75640  ? 98  THR A CB   1 
ATOM   1501 O OG1  . THR A 1 98  ? -16.31330 -48.02677 17.32487  1.000 28.35146  ? 98  THR A OG1  1 
ATOM   1502 C CG2  . THR A 1 98  ? -17.67013 -46.85622 18.92608  1.000 28.94393  ? 98  THR A CG2  1 
ATOM   1503 H H    . THR A 1 98  ? -14.19782 -48.71562 18.76433  1.000 31.68080  ? 98  THR A H    1 
ATOM   1504 H HA   . THR A 1 98  ? -15.06099 -46.28267 18.76622  1.000 31.73139  ? 98  THR A HA   1 
ATOM   1505 H HB   . THR A 1 98  ? -16.61685 -48.60044 19.19097  1.000 33.29473  ? 98  THR A HB   1 
ATOM   1506 H HG1  . THR A 1 98  ? -16.13136 -48.83777 17.20325  1.000 34.00880  ? 98  THR A HG1  1 
ATOM   1507 H HG21 . THR A 1 98  ? -17.39249 -45.92711 18.90244  1.000 34.71977  ? 98  THR A HG21 1 
ATOM   1508 H HG22 . THR A 1 98  ? -18.32217 -47.00788 18.22412  1.000 34.71977  ? 98  THR A HG22 1 
ATOM   1509 H HG23 . THR A 1 98  ? -18.08317 -47.03961 19.78437  1.000 34.71977  ? 98  THR A HG23 1 
ATOM   1510 N N    . PRO A 1 99  ? -15.40569 -45.48881 21.12822  1.000 27.28989  ? 99  PRO A N    1 
ATOM   1511 C CA   . PRO A 1 99  ? -15.72915 -45.12218 22.50959  1.000 29.18501  ? 99  PRO A CA   1 
ATOM   1512 C C    . PRO A 1 99  ? -17.23342 -45.06052 22.72075  1.000 27.11828  ? 99  PRO A C    1 
ATOM   1513 O O    . PRO A 1 99  ? -18.02308 -45.07110 21.77723  1.000 27.64537  ? 99  PRO A O    1 
ATOM   1514 C CB   . PRO A 1 99  ? -15.10787 -43.73176 22.64565  1.000 28.67382  ? 99  PRO A CB   1 
ATOM   1515 C CG   . PRO A 1 99  ? -15.30196 -43.15233 21.27330  1.000 28.14969  ? 99  PRO A CG   1 
ATOM   1516 C CD   . PRO A 1 99  ? -15.03608 -44.30354 20.32822  1.000 27.64224  ? 99  PRO A CD   1 
ATOM   1517 H HA   . PRO A 1 99  ? -15.32725 -45.73656 23.14355  1.000 35.00906  ? 99  PRO A HA   1 
ATOM   1518 H HB2  . PRO A 1 99  ? -15.57577 -43.21470 23.31990  1.000 34.39563  ? 99  PRO A HB2  1 
ATOM   1519 H HB3  . PRO A 1 99  ? -14.16750 -43.80027 22.87348  1.000 34.39563  ? 99  PRO A HB3  1 
ATOM   1520 H HG2  . PRO A 1 99  ? -16.21022 -42.82582 21.17654  1.000 33.76668  ? 99  PRO A HG2  1 
ATOM   1521 H HG3  . PRO A 1 99  ? -14.67212 -42.42940 21.12638  1.000 33.76668  ? 99  PRO A HG3  1 
ATOM   1522 H HD2  . PRO A 1 99  ? -15.59076 -44.23501 19.53542  1.000 33.15774  ? 99  PRO A HD2  1 
ATOM   1523 H HD3  . PRO A 1 99  ? -14.09985 -44.33479 20.07641  1.000 33.15774  ? 99  PRO A HD3  1 
ATOM   1524 N N    . LYS A 1 100 ? -17.62441 -44.99834 23.99261  1.000 25.95167  ? 100 LYS A N    1 
ATOM   1525 C CA   . LYS A 1 100 ? -18.96435 -44.52998 24.31398  1.000 28.90617  ? 100 LYS A CA   1 
ATOM   1526 C C    . LYS A 1 100 ? -19.14655 -43.15167 23.69132  1.000 29.98545  ? 100 LYS A C    1 
ATOM   1527 O O    . LYS A 1 100 ? -18.31940 -42.25620 23.89423  1.000 27.27369  ? 100 LYS A O    1 
ATOM   1528 C CB   . LYS A 1 100 ? -19.17171 -44.45740 25.83084  1.000 35.45434  ? 100 LYS A CB   1 
ATOM   1529 C CG   . LYS A 1 100 ? -18.76496 -45.70120 26.61073  1.000 39.81012  ? 100 LYS A CG   1 
ATOM   1530 C CD   . LYS A 1 100 ? -19.18967 -45.59347 28.08125  1.000 52.46797  ? 100 LYS A CD   1 
ATOM   1531 C CE   . LYS A 1 100 ? -18.10755 -46.10254 29.03269  1.000 59.77083  ? 100 LYS A CE   1 
ATOM   1532 N NZ   . LYS A 1 100 ? -18.65664 -46.61557 30.32687  1.000 59.91065  ? 100 LYS A NZ   1 
ATOM   1533 H H    . LYS A 1 100 ? -17.14224 -45.21704 24.67031  1.000 31.12905  ? 100 LYS A H    1 
ATOM   1534 H HA   . LYS A 1 100 ? -19.62796 -45.14647 23.96690  1.000 34.67445  ? 100 LYS A HA   1 
ATOM   1535 H HB2  . LYS A 1 100 ? -18.64768 -43.71719 26.17492  1.000 42.53226  ? 100 LYS A HB2  1 
ATOM   1536 H HB3  . LYS A 1 100 ? -20.11411 -44.30481 26.00257  1.000 42.53226  ? 100 LYS A HB3  1 
ATOM   1537 H HG2  . LYS A 1 100 ? -19.19462 -46.47997 26.22367  1.000 47.75919  ? 100 LYS A HG2  1 
ATOM   1538 H HG3  . LYS A 1 100 ? -17.80091 -45.80290 26.57660  1.000 47.75919  ? 100 LYS A HG3  1 
ATOM   1539 H HD2  . LYS A 1 100 ? -19.36657 -44.66392 28.29468  1.000 62.94861  ? 100 LYS A HD2  1 
ATOM   1540 H HD3  . LYS A 1 100 ? -19.98941 -46.12411 28.22177  1.000 62.94861  ? 100 LYS A HD3  1 
ATOM   1541 H HE2  . LYS A 1 100 ? -17.62735 -46.82818 28.60403  1.000 71.71204  ? 100 LYS A HE2  1 
ATOM   1542 H HE3  . LYS A 1 100 ? -17.49835 -45.37525 29.23472  1.000 71.71204  ? 100 LYS A HE3  1 
ATOM   1543 H HZ1  . LYS A 1 100 ? -19.24373 -47.26626 30.17183  1.000 71.87982  ? 100 LYS A HZ1  1 
ATOM   1544 H HZ2  . LYS A 1 100 ? -17.99728 -46.93572 30.83170  1.000 71.87982  ? 100 LYS A HZ2  1 
ATOM   1545 H HZ3  . LYS A 1 100 ? -19.06396 -45.95781 30.76679  1.000 71.87982  ? 100 LYS A HZ3  1 
ATOM   1546 N N    . TYR A 1 101 ? -20.21505 -42.97841 22.91578  1.000 28.41678  ? 101 TYR A N    1 
ATOM   1547 C CA   . TYR A 1 101 ? -20.35972 -41.74618 22.15891  1.000 28.97253  ? 101 TYR A CA   1 
ATOM   1548 C C    . TYR A 1 101 ? -21.82631 -41.35837 22.03091  1.000 29.73954  ? 101 TYR A C    1 
ATOM   1549 O O    . TYR A 1 101 ? -22.73199 -42.16422 22.25858  1.000 30.62113  ? 101 TYR A O    1 
ATOM   1550 C CB   . TYR A 1 101 ? -19.71183 -41.86980 20.76619  1.000 29.66737  ? 101 TYR A CB   1 
ATOM   1551 C CG   . TYR A 1 101 ? -20.47095 -42.74069 19.78180  1.000 28.49276  ? 101 TYR A CG   1 
ATOM   1552 C CD1  . TYR A 1 101 ? -20.21026 -44.09818 19.67815  1.000 28.98702  ? 101 TYR A CD1  1 
ATOM   1553 C CD2  . TYR A 1 101 ? -21.43664 -42.19617 18.94667  1.000 29.71318  ? 101 TYR A CD2  1 
ATOM   1554 C CE1  . TYR A 1 101 ? -20.89774 -44.89294 18.77796  1.000 29.69291  ? 101 TYR A CE1  1 
ATOM   1555 C CE2  . TYR A 1 101 ? -22.13144 -42.98205 18.04488  1.000 29.49540  ? 101 TYR A CE2  1 
ATOM   1556 C CZ   . TYR A 1 101 ? -21.86083 -44.32900 17.96540  1.000 30.69895  ? 101 TYR A CZ   1 
ATOM   1557 O OH   . TYR A 1 101 ? -22.55064 -45.10915 17.06350  1.000 28.82790  ? 101 TYR A OH   1 
ATOM   1558 H H    . TYR A 1 101 ? -20.85196 -43.54763 22.81615  1.000 34.08718  ? 101 TYR A H    1 
ATOM   1559 H HA   . TYR A 1 101 ? -19.92377 -41.03300 22.65107  1.000 34.75408  ? 101 TYR A HA   1 
ATOM   1560 H HB2  . TYR A 1 101 ? -19.64490 -40.98308 20.37871  1.000 35.58789  ? 101 TYR A HB2  1 
ATOM   1561 H HB3  . TYR A 1 101 ? -18.82715 -42.25331 20.87187  1.000 35.58789  ? 101 TYR A HB3  1 
ATOM   1562 H HD1  . TYR A 1 101 ? -19.56171 -44.48161 20.22338  1.000 34.77147  ? 101 TYR A HD1  1 
ATOM   1563 H HD2  . TYR A 1 101 ? -21.62006 -41.28568 18.99428  1.000 35.64287  ? 101 TYR A HD2  1 
ATOM   1564 H HE1  . TYR A 1 101 ? -20.71195 -45.80239 18.72062  1.000 35.61853  ? 101 TYR A HE1  1 
ATOM   1565 H HE2  . TYR A 1 101 ? -22.77816 -42.60205 17.49511  1.000 35.38153  ? 101 TYR A HE2  1 
ATOM   1566 H HH   . TYR A 1 101 ? -22.11461 -45.80703 16.89483  1.000 34.58053  ? 101 TYR A HH   1 
ATOM   1567 N N    . LYS A 1 102 ? -22.03339 -40.09514 21.65883  1.000 28.92585  ? 102 LYS A N    1 
ATOM   1568 C CA   . LYS A 1 102 ? -23.34355 -39.54337 21.35532  1.000 31.51182  ? 102 LYS A CA   1 
ATOM   1569 C C    . LYS A 1 102 ? -23.18092 -38.49635 20.25997  1.000 28.29518  ? 102 LYS A C    1 
ATOM   1570 O O    . LYS A 1 102 ? -22.10148 -37.93048 20.07906  1.000 27.74878  ? 102 LYS A O    1 
ATOM   1571 C CB   . LYS A 1 102 ? -23.99481 -38.90072 22.58885  1.000 33.74982  ? 102 LYS A CB   1 
ATOM   1572 C CG   . LYS A 1 102 ? -24.46375 -39.88185 23.64514  1.000 41.49023  ? 102 LYS A CG   1 
ATOM   1573 C CD   . LYS A 1 102 ? -25.31127 -39.19921 24.71233  1.000 65.96748  ? 102 LYS A CD   1 
ATOM   1574 C CE   . LYS A 1 102 ? -24.53174 -38.13611 25.47837  1.000 59.01549  ? 102 LYS A CE   1 
ATOM   1575 N NZ   . LYS A 1 102 ? -24.93537 -36.75494 25.09653  1.000 67.82492  ? 102 LYS A NZ   1 
ATOM   1576 H H    . LYS A 1 102 ? -21.40243 -39.51719 21.57248  1.000 34.69806  ? 102 LYS A H    1 
ATOM   1577 H HA   . LYS A 1 102 ? -23.92297 -40.25402 21.03883  1.000 37.80124  ? 102 LYS A HA   1 
ATOM   1578 H HB2  . LYS A 1 102 ? -23.34785 -38.31047 23.00590  1.000 40.48683  ? 102 LYS A HB2  1 
ATOM   1579 H HB3  . LYS A 1 102 ? -24.76859 -38.39280 22.29869  1.000 40.48683  ? 102 LYS A HB3  1 
ATOM   1580 H HG2  . LYS A 1 102 ? -25.00116 -40.57185 23.22562  1.000 49.77532  ? 102 LYS A HG2  1 
ATOM   1581 H HG3  . LYS A 1 102 ? -23.69226 -40.27961 24.07815  1.000 49.77532  ? 102 LYS A HG3  1 
ATOM   1582 H HD2  . LYS A 1 102 ? -26.07067 -38.76937 24.28872  1.000 79.14802  ? 102 LYS A HD2  1 
ATOM   1583 H HD3  . LYS A 1 102 ? -25.61857 -39.86423 25.34811  1.000 79.14802  ? 102 LYS A HD3  1 
ATOM   1584 H HE2  . LYS A 1 102 ? -24.69352 -38.24589 26.42846  1.000 70.80564  ? 102 LYS A HE2  1 
ATOM   1585 H HE3  . LYS A 1 102 ? -23.58577 -38.23716 25.28906  1.000 70.80564  ? 102 LYS A HE3  1 
ATOM   1586 H HZ1  . LYS A 1 102 ? -25.76284 -36.59032 25.37989  1.000 81.37694  ? 102 LYS A HZ1  1 
ATOM   1587 H HZ2  . LYS A 1 102 ? -24.38120 -36.16331 25.46392  1.000 81.37694  ? 102 LYS A HZ2  1 
ATOM   1588 H HZ3  . LYS A 1 102 ? -24.90966 -36.66397 24.21157  1.000 81.37694  ? 102 LYS A HZ3  1 
ATOM   1589 N N    . PHE A 1 103 ? -24.26618 -38.24637 19.53002  1.000 27.06314  ? 103 PHE A N    1 
ATOM   1590 C CA   . PHE A 1 103 ? -24.35042 -37.15618 18.56284  1.000 28.91919  ? 103 PHE A CA   1 
ATOM   1591 C C    . PHE A 1 103 ? -25.22907 -36.06572 19.16177  1.000 29.20344  ? 103 PHE A C    1 
ATOM   1592 O O    . PHE A 1 103 ? -26.39164 -36.31953 19.49571  1.000 28.90603  ? 103 PHE A O    1 
ATOM   1593 C CB   . PHE A 1 103 ? -24.94042 -37.62190 17.22779  1.000 28.65319  ? 103 PHE A CB   1 
ATOM   1594 C CG   . PHE A 1 103 ? -24.04970 -38.54164 16.43225  1.000 27.03152  ? 103 PHE A CG   1 
ATOM   1595 C CD1  . PHE A 1 103 ? -22.72388 -38.74553 16.77444  1.000 27.77969  ? 103 PHE A CD1  1 
ATOM   1596 C CD2  . PHE A 1 103 ? -24.55496 -39.20078 15.32521  1.000 26.68850  ? 103 PHE A CD2  1 
ATOM   1597 C CE1  . PHE A 1 103 ? -21.92568 -39.59301 16.02864  1.000 27.45209  ? 103 PHE A CE1  1 
ATOM   1598 C CE2  . PHE A 1 103 ? -23.76655 -40.04298 14.57775  1.000 27.55400  ? 103 PHE A CE2  1 
ATOM   1599 C CZ   . PHE A 1 103 ? -22.44825 -40.24264 14.92577  1.000 26.91160  ? 103 PHE A CZ   1 
ATOM   1600 H H    . PHE A 1 103 ? -24.98874 -38.71007 19.57985  1.000 32.46281  ? 103 PHE A H    1 
ATOM   1601 H HA   . PHE A 1 103 ? -23.46029 -36.80991 18.39355  1.000 34.69007  ? 103 PHE A HA   1 
ATOM   1602 H HB2  . PHE A 1 103 ? -25.76708 -38.09735 17.40524  1.000 34.37087  ? 103 PHE A HB2  1 
ATOM   1603 H HB3  . PHE A 1 103 ? -25.11771 -36.84122 16.68007  1.000 34.37087  ? 103 PHE A HB3  1 
ATOM   1604 H HD1  . PHE A 1 103 ? -22.36657 -38.30810 17.51329  1.000 33.32267  ? 103 PHE A HD1  1 
ATOM   1605 H HD2  . PHE A 1 103 ? -25.44346 -39.07167 15.08273  1.000 32.01324  ? 103 PHE A HD2  1 
ATOM   1606 H HE1  . PHE A 1 103 ? -21.03716 -39.72610 16.26888  1.000 32.92955  ? 103 PHE A HE1  1 
ATOM   1607 H HE2  . PHE A 1 103 ? -24.12291 -40.47808 13.83707  1.000 33.05185  ? 103 PHE A HE2  1 
ATOM   1608 H HZ   . PHE A 1 103 ? -21.91274 -40.81153 14.42130  1.000 32.28097  ? 103 PHE A HZ   1 
ATOM   1609 N N    . VAL A 1 104 ? -24.68728 -34.85609 19.28297  1.000 28.45004  ? 104 VAL A N    1 
ATOM   1610 C CA   . VAL A 1 104 ? -25.44769 -33.73241 19.81348  1.000 28.48745  ? 104 VAL A CA   1 
ATOM   1611 C C    . VAL A 1 104 ? -25.28601 -32.54215 18.88535  1.000 29.85517  ? 104 VAL A C    1 
ATOM   1612 O O    . VAL A 1 104 ? -24.22703 -32.33374 18.28428  1.000 30.61480  ? 104 VAL A O    1 
ATOM   1613 C CB   . VAL A 1 104 ? -25.01592 -33.34415 21.24888  1.000 29.85510  ? 104 VAL A CB   1 
ATOM   1614 C CG1  . VAL A 1 104 ? -24.74531 -34.57781 22.08194  1.000 30.30958  ? 104 VAL A CG1  1 
ATOM   1615 C CG2  . VAL A 1 104 ? -23.80039 -32.42707 21.22368  1.000 32.18632  ? 104 VAL A CG2  1 
ATOM   1616 H H    . VAL A 1 104 ? -23.87847 -34.66315 19.06341  1.000 34.12710  ? 104 VAL A H    1 
ATOM   1617 H HA   . VAL A 1 104 ? -26.38381 -33.98549 19.83674  1.000 34.17198  ? 104 VAL A HA   1 
ATOM   1618 H HB   . VAL A 1 104 ? -25.74376 -32.85739 21.66627  1.000 35.81316  ? 104 VAL A HB   1 
ATOM   1619 H HG11 . VAL A 1 104 ? -24.57749 -34.30919 22.99877  1.000 36.35854  ? 104 VAL A HG11 1 
ATOM   1620 H HG12 . VAL A 1 104 ? -25.52000 -35.16035 22.04446  1.000 36.35854  ? 104 VAL A HG12 1 
ATOM   1621 H HG13 . VAL A 1 104 ? -23.96900 -35.03638 21.72423  1.000 36.35854  ? 104 VAL A HG13 1 
ATOM   1622 H HG21 . VAL A 1 104 ? -23.37714 -32.43966 22.09638  1.000 38.61063  ? 104 VAL A HG21 1 
ATOM   1623 H HG22 . VAL A 1 104 ? -23.17896 -32.74483 20.55006  1.000 38.61063  ? 104 VAL A HG22 1 
ATOM   1624 H HG23 . VAL A 1 104 ? -24.08886 -31.52620 21.00892  1.000 38.61063  ? 104 VAL A HG23 1 
ATOM   1625 N N    . ARG A 1 105 ? -26.35043 -31.75792 18.76844  1.000 28.23374  ? 105 ARG A N    1 
ATOM   1626 C CA   . ARG A 1 105 ? -26.30237 -30.46146 18.10751  1.000 29.85767  ? 105 ARG A CA   1 
ATOM   1627 C C    . ARG A 1 105 ? -26.17839 -29.39747 19.19179  1.000 32.92802  ? 105 ARG A C    1 
ATOM   1628 O O    . ARG A 1 105 ? -27.03623 -29.31199 20.07674  1.000 31.03808  ? 105 ARG A O    1 
ATOM   1629 C CB   . ARG A 1 105 ? -27.55074 -30.23015 17.25517  1.000 32.80420  ? 105 ARG A CB   1 
ATOM   1630 C CG   . ARG A 1 105 ? -27.44949 -29.04451 16.30975  1.000 30.57978  ? 105 ARG A CG   1 
ATOM   1631 C CD   . ARG A 1 105 ? -28.69141 -28.91897 15.44149  1.000 30.99550  ? 105 ARG A CD   1 
ATOM   1632 N NE   . ARG A 1 105 ? -28.69626 -27.67463 14.68408  1.000 33.51640  ? 105 ARG A NE   1 
ATOM   1633 C CZ   . ARG A 1 105 ? -28.14943 -27.52122 13.48640  1.000 33.78988  ? 105 ARG A CZ   1 
ATOM   1634 N NH1  . ARG A 1 105 ? -27.55079 -28.52459 12.86533  1.000 29.13809  ? 105 ARG A NH1  1 
ATOM   1635 N NH2  . ARG A 1 105 ? -28.20483 -26.33127 12.89671  1.000 37.16127  ? 105 ARG A NH2  1 
ATOM   1636 H H    . ARG A 1 105 ? -27.12950 -31.96031 19.07122  1.000 33.86753  ? 105 ARG A H    1 
ATOM   1637 H HA   . ARG A 1 105 ? -25.53400 -30.41113 17.51762  1.000 35.81625  ? 105 ARG A HA   1 
ATOM   1638 H HB2  . ARG A 1 105 ? -27.71038 -31.02189 16.71800  1.000 39.35208  ? 105 ARG A HB2  1 
ATOM   1639 H HB3  . ARG A 1 105 ? -28.30414 -30.07222 17.84538  1.000 39.35208  ? 105 ARG A HB3  1 
ATOM   1640 H HG2  . ARG A 1 105 ? -27.35426 -28.22879 16.82593  1.000 36.68278  ? 105 ARG A HG2  1 
ATOM   1641 H HG3  . ARG A 1 105 ? -26.68148 -29.16108 15.72882  1.000 36.68278  ? 105 ARG A HG3  1 
ATOM   1642 H HD2  . ARG A 1 105 ? -28.71892 -29.65752 14.81325  1.000 37.18165  ? 105 ARG A HD2  1 
ATOM   1643 H HD3  . ARG A 1 105 ? -29.47988 -28.93431 16.00627  1.000 37.18165  ? 105 ARG A HD3  1 
ATOM   1644 H HE   . ARG A 1 105 ? -29.08071 -26.99197 15.03872  1.000 40.20672  ? 105 ARG A HE   1 
ATOM   1645 H HH11 . ARG A 1 105 ? -27.50998 -29.29832 13.23853  1.000 34.95275  ? 105 ARG A HH11 1 
ATOM   1646 H HH12 . ARG A 1 105 ? -27.20252 -28.40299 12.08846  1.000 34.95275  ? 105 ARG A HH12 1 
ATOM   1647 H HH21 . ARG A 1 105 ? -28.59193 -25.67298 13.29220  1.000 44.58057  ? 105 ARG A HH21 1 
ATOM   1648 H HH22 . ARG A 1 105 ? -27.85358 -26.21966 12.11969  1.000 44.58057  ? 105 ARG A HH22 1 
ATOM   1649 N N    . ILE A 1 106 ? -25.10899 -28.60827 19.13739  1.000 31.79229  ? 106 ILE A N    1 
ATOM   1650 C CA   . ILE A 1 106 ? -24.86316 -27.60201 20.15731  1.000 31.88243  ? 106 ILE A CA   1 
ATOM   1651 C C    . ILE A 1 106 ? -25.58505 -26.31264 19.78740  1.000 34.64162  ? 106 ILE A C    1 
ATOM   1652 O O    . ILE A 1 106 ? -26.00655 -26.10182 18.64566  1.000 33.09472  ? 106 ILE A O    1 
ATOM   1653 C CB   . ILE A 1 106 ? -23.35782 -27.33165 20.37076  1.000 32.09437  ? 106 ILE A CB   1 
ATOM   1654 C CG1  . ILE A 1 106 ? -22.67316 -27.00185 19.04609  1.000 31.63140  ? 106 ILE A CG1  1 
ATOM   1655 C CG2  . ILE A 1 106 ? -22.69000 -28.50908 21.04713  1.000 33.47213  ? 106 ILE A CG2  1 
ATOM   1656 C CD1  . ILE A 1 106 ? -21.33174 -26.31576 19.22251  1.000 34.13941  ? 106 ILE A CD1  1 
ATOM   1657 H H    . ILE A 1 106 ? -24.51260 -28.63836 18.51851  1.000 38.13779  ? 106 ILE A H    1 
ATOM   1658 H HA   . ILE A 1 106 ? -25.23055 -27.93372 20.99151  1.000 38.24597  ? 106 ILE A HA   1 
ATOM   1659 H HB   . ILE A 1 106 ? -23.27188 -26.56095 20.95345  1.000 38.50029  ? 106 ILE A HB   1 
ATOM   1660 H HG12 . ILE A 1 106 ? -22.52511 -27.82535 18.55534  1.000 37.94473  ? 106 ILE A HG12 1 
ATOM   1661 H HG13 . ILE A 1 106 ? -23.24657 -26.40954 18.53495  1.000 37.94473  ? 106 ILE A HG13 1 
ATOM   1662 H HG21 . ILE A 1 106 ? -23.28888 -28.86771 21.72065  1.000 40.15360  ? 106 ILE A HG21 1 
ATOM   1663 H HG22 . ILE A 1 106 ? -22.49653 -29.18759 20.38148  1.000 40.15360  ? 106 ILE A HG22 1 
ATOM   1664 H HG23 . ILE A 1 106 ? -21.86647 -28.20911 21.46273  1.000 40.15360  ? 106 ILE A HG23 1 
ATOM   1665 H HD11 . ILE A 1 106 ? -20.91664 -26.20548 18.35278  1.000 40.95434  ? 106 ILE A HD11 1 
ATOM   1666 H HD12 . ILE A 1 106 ? -21.47218 -25.44882 19.63432  1.000 40.95434  ? 106 ILE A HD12 1 
ATOM   1667 H HD13 . ILE A 1 106 ? -20.76866 -26.86449 19.79059  1.000 40.95434  ? 106 ILE A HD13 1 
ATOM   1668 N N    . GLN A 1 107 ? -25.71618 -25.43589 20.77401  1.000 35.20462  ? 107 GLN A N    1 
ATOM   1669 C CA   . GLN A 1 107 ? -26.28385 -24.10848 20.62165  1.000 37.50577  ? 107 GLN A CA   1 
ATOM   1670 C C    . GLN A 1 107 ? -25.17772 -23.07891 20.45272  1.000 34.80149  ? 107 GLN A C    1 
ATOM   1671 O O    . GLN A 1 107 ? -24.03783 -23.30036 20.87254  1.000 33.07333  ? 107 GLN A O    1 
ATOM   1672 C CB   . GLN A 1 107 ? -27.13461 -23.75165 21.84704  1.000 40.75744  ? 107 GLN A CB   1 
ATOM   1673 C CG   . GLN A 1 107 ? -28.50639 -24.41169 21.88445  1.000 44.93146  ? 107 GLN A CG   1 
ATOM   1674 C CD   . GLN A 1 107 ? -29.51025 -23.71293 20.98620  1.000 52.34078  ? 107 GLN A CD   1 
ATOM   1675 O OE1  . GLN A 1 107 ? -29.44013 -23.81185 19.76058  1.000 54.76961  ? 107 GLN A OE1  1 
ATOM   1676 N NE2  . GLN A 1 107 ? -30.44804 -22.99451 21.59383  1.000 53.14779  ? 107 GLN A NE2  1 
ATOM   1677 H H    . GLN A 1 107 ? -25.47010 -25.59728 21.58209  1.000 42.23259  ? 107 GLN A H    1 
ATOM   1678 H HA   . GLN A 1 107 ? -26.85516 -24.08285 19.83817  1.000 44.99398  ? 107 GLN A HA   1 
ATOM   1679 H HB2  . GLN A 1 107 ? -26.65633 -24.02690 22.64478  1.000 48.89598  ? 107 GLN A HB2  1 
ATOM   1680 H HB3  . GLN A 1 107 ? -27.27221 -22.79151 21.85743  1.000 48.89598  ? 107 GLN A HB3  1 
ATOM   1681 H HG2  . GLN A 1 107 ? -28.42434 -25.33113 21.58647  1.000 53.90479  ? 107 GLN A HG2  1 
ATOM   1682 H HG3  . GLN A 1 107 ? -28.84603 -24.38635 22.79269  1.000 53.90479  ? 107 GLN A HG3  1 
ATOM   1683 H HE21 . GLN A 1 107 ? -30.46279 -22.94468 22.45226  1.000 63.76440  ? 107 GLN A HE21 1 
ATOM   1684 H HE22 . GLN A 1 107 ? -31.04039 -22.57925 21.12876  1.000 63.76440  ? 107 GLN A HE22 1 
ATOM   1685 N N    . PRO A 1 108 ? -25.47073 -21.93679 19.83226  1.000 34.13097  ? 108 PRO A N    1 
ATOM   1686 C CA   . PRO A 1 108 ? -24.47678 -20.85885 19.79203  1.000 33.12200  ? 108 PRO A CA   1 
ATOM   1687 C C    . PRO A 1 108 ? -24.05287 -20.46985 21.20087  1.000 33.09735  ? 108 PRO A C    1 
ATOM   1688 O O    . PRO A 1 108 ? -24.86318 -20.45184 22.12865  1.000 31.82168  ? 108 PRO A O    1 
ATOM   1689 C CB   . PRO A 1 108 ? -25.20709 -19.71672 19.07259  1.000 35.39722  ? 108 PRO A CB   1 
ATOM   1690 C CG   . PRO A 1 108 ? -26.65251 -20.11209 19.03255  1.000 34.91207  ? 108 PRO A CG   1 
ATOM   1691 C CD   . PRO A 1 108 ? -26.68677 -21.59924 19.07350  1.000 35.96700  ? 108 PRO A CD   1 
ATOM   1692 H HA   . PRO A 1 108 ? -23.70001 -21.11497 19.27056  1.000 39.73344  ? 108 PRO A HA   1 
ATOM   1693 H HB2  . PRO A 1 108 ? -25.09026 -18.89130 19.56851  1.000 42.46371  ? 108 PRO A HB2  1 
ATOM   1694 H HB3  . PRO A 1 108 ? -24.85304 -19.61741 18.17499  1.000 42.46371  ? 108 PRO A HB3  1 
ATOM   1695 H HG2  . PRO A 1 108 ? -27.11209 -19.73920 19.80108  1.000 41.88153  ? 108 PRO A HG2  1 
ATOM   1696 H HG3  . PRO A 1 108 ? -27.05580 -19.78421 18.21356  1.000 41.88153  ? 108 PRO A HG3  1 
ATOM   1697 H HD2  . PRO A 1 108 ? -27.48062 -21.91504 19.53281  1.000 43.14744  ? 108 PRO A HD2  1 
ATOM   1698 H HD3  . PRO A 1 108 ? -26.65120 -21.97143 18.17845  1.000 43.14744  ? 108 PRO A HD3  1 
ATOM   1699 N N    . GLY A 1 109 ? -22.75811 -20.18137 21.35841  1.000 28.65434  ? 109 GLY A N    1 
ATOM   1700 C CA   . GLY A 1 109 ? -22.16369 -19.88234 22.63737  1.000 29.45787  ? 109 GLY A CA   1 
ATOM   1701 C C    . GLY A 1 109 ? -21.43368 -21.05242 23.26822  1.000 31.30096  ? 109 GLY A C    1 
ATOM   1702 O O    . GLY A 1 109 ? -20.50919 -20.83942 24.06257  1.000 31.66784  ? 109 GLY A O    1 
ATOM   1703 H H    . GLY A 1 109 ? -22.19521 -20.15509 20.70875  1.000 34.37225  ? 109 GLY A H    1 
ATOM   1704 H HA2  . GLY A 1 109 ? -21.52818 -19.15793 22.52664  1.000 35.33649  ? 109 GLY A HA2  1 
ATOM   1705 H HA3  . GLY A 1 109 ? -22.86111 -19.59981 23.24947  1.000 35.33649  ? 109 GLY A HA3  1 
ATOM   1706 N N    . GLN A 1 110 ? -21.82923 -22.28009 22.94241  1.000 27.77119  ? 110 GLN A N    1 
ATOM   1707 C CA   . GLN A 1 110 ? -21.16872 -23.44863 23.49800  1.000 31.34151  ? 110 GLN A CA   1 
ATOM   1708 C C    . GLN A 1 110 ? -19.84576 -23.69951 22.78115  1.000 30.04370  ? 110 GLN A C    1 
ATOM   1709 O O    . GLN A 1 110 ? -19.62620 -23.25688 21.65056  1.000 28.30630  ? 110 GLN A O    1 
ATOM   1710 C CB   . GLN A 1 110 ? -22.06521 -24.68268 23.39574  1.000 33.64103  ? 110 GLN A CB   1 
ATOM   1711 C CG   . GLN A 1 110 ? -23.29189 -24.63060 24.29569  1.000 40.43276  ? 110 GLN A CG   1 
ATOM   1712 C CD   . GLN A 1 110 ? -24.09444 -25.91918 24.26263  1.000 41.30046  ? 110 GLN A CD   1 
ATOM   1713 O OE1  . GLN A 1 110 ? -24.92161 -26.12515 23.37716  1.000 39.08622  ? 110 GLN A OE1  1 
ATOM   1714 N NE2  . GLN A 1 110 ? -23.85231 -26.79375 25.23448  1.000 44.51009  ? 110 GLN A NE2  1 
ATOM   1715 H H    . GLN A 1 110 ? -22.47530 -22.45893 22.40371  1.000 33.31248  ? 110 GLN A H    1 
ATOM   1716 H HA   . GLN A 1 110 ? -20.98403 -23.29605 24.43795  1.000 37.59685  ? 110 GLN A HA   1 
ATOM   1717 H HB2  . GLN A 1 110 ? -22.37389 -24.76805 22.48013  1.000 40.35628  ? 110 GLN A HB2  1 
ATOM   1718 H HB3  . GLN A 1 110 ? -21.54826 -25.46443 23.64581  1.000 40.35628  ? 110 GLN A HB3  1 
ATOM   1719 H HG2  . GLN A 1 110 ? -23.00752 -24.47687 25.21024  1.000 48.50636  ? 110 GLN A HG2  1 
ATOM   1720 H HG3  . GLN A 1 110 ? -23.86971 -23.90889 24.00217  1.000 48.50636  ? 110 GLN A HG3  1 
ATOM   1721 H HE21 . GLN A 1 110 ? -23.26661 -26.61452 25.83816  1.000 53.39916  ? 110 GLN A HE21 1 
ATOM   1722 H HE22 . GLN A 1 110 ? -24.28141 -27.53864 25.25938  1.000 53.39916  ? 110 GLN A HE22 1 
ATOM   1723 N N    . THR A 1 111 ? -18.96151 -24.42005 23.46063  1.000 29.02805  ? 111 THR A N    1 
ATOM   1724 C CA   . THR A 1 111 ? -17.61112 -24.66773 22.98224  1.000 30.61885  ? 111 THR A CA   1 
ATOM   1725 C C    . THR A 1 111 ? -17.38940 -26.16068 22.76841  1.000 26.79809  ? 111 THR A C    1 
ATOM   1726 O O    . THR A 1 111 ? -18.12211 -27.00533 23.29207  1.000 29.73804  ? 111 THR A O    1 
ATOM   1727 C CB   . THR A 1 111 ? -16.56932 -24.12452 23.97144  1.000 29.14231  ? 111 THR A CB   1 
ATOM   1728 O OG1  . THR A 1 111 ? -16.70883 -24.80087 25.22763  1.000 31.90828  ? 111 THR A OG1  1 
ATOM   1729 C CG2  . THR A 1 111 ? -16.75337 -22.62306 24.18633  1.000 29.15920  ? 111 THR A CG2  1 
ATOM   1730 H H    . THR A 1 111 ? -19.12672 -24.78489 24.22169  1.000 34.82071  ? 111 THR A H    1 
ATOM   1731 H HA   . THR A 1 111 ? -17.48908 -24.22373 22.12850  1.000 36.72967  ? 111 THR A HA   1 
ATOM   1732 H HB   . THR A 1 111 ? -15.67954 -24.27252 23.61468  1.000 34.95781  ? 111 THR A HB   1 
ATOM   1733 H HG1  . THR A 1 111 ? -16.54217 -25.61878 25.13361  1.000 38.27698  ? 111 THR A HG1  1 
ATOM   1734 H HG21 . THR A 1 111 ? -17.69777 -22.40967 24.24532  1.000 34.97809  ? 111 THR A HG21 1 
ATOM   1735 H HG22 . THR A 1 111 ? -16.31691 -22.34960 25.00829  1.000 34.97809  ? 111 THR A HG22 1 
ATOM   1736 H HG23 . THR A 1 111 ? -16.36533 -22.13185 23.44537  1.000 34.97809  ? 111 THR A HG23 1 
ATOM   1737 N N    . PHE A 1 112 ? -16.35437 -26.47570 21.99398  1.000 28.25661  ? 112 PHE A N    1 
ATOM   1738 C CA   . PHE A 1 112 ? -16.00899 -27.85878 21.69748  1.000 28.48582  ? 112 PHE A CA   1 
ATOM   1739 C C    . PHE A 1 112 ? -14.57512 -27.90551 21.18857  1.000 27.92435  ? 112 PHE A C    1 
ATOM   1740 O O    . PHE A 1 112 ? -14.00055 -26.88479 20.80563  1.000 27.85728  ? 112 PHE A O    1 
ATOM   1741 C CB   . PHE A 1 112 ? -16.96985 -28.46237 20.66939  1.000 28.70043  ? 112 PHE A CB   1 
ATOM   1742 C CG   . PHE A 1 112 ? -17.03189 -27.69738 19.37987  1.000 28.32934  ? 112 PHE A CG   1 
ATOM   1743 C CD1  . PHE A 1 112 ? -17.90668 -26.63577 19.22872  1.000 29.74968  ? 112 PHE A CD1  1 
ATOM   1744 C CD2  . PHE A 1 112 ? -16.21605 -28.04135 18.31567  1.000 28.22737  ? 112 PHE A CD2  1 
ATOM   1745 C CE1  . PHE A 1 112 ? -17.96485 -25.92924 18.03899  1.000 28.73159  ? 112 PHE A CE1  1 
ATOM   1746 C CE2  . PHE A 1 112 ? -16.27082 -27.34274 17.12909  1.000 25.30640  ? 112 PHE A CE2  1 
ATOM   1747 C CZ   . PHE A 1 112 ? -17.14398 -26.28329 16.98975  1.000 27.46832  ? 112 PHE A CZ   1 
ATOM   1748 H H    . PHE A 1 112 ? -15.83268 -25.89977 21.62555  1.000 33.89498  ? 112 PHE A H    1 
ATOM   1749 H HA   . PHE A 1 112 ? -16.05854 -28.38721 22.50939  1.000 34.17003  ? 112 PHE A HA   1 
ATOM   1750 H HB2  . PHE A 1 112 ? -16.68081 -29.36537 20.46459  1.000 34.42757  ? 112 PHE A HB2  1 
ATOM   1751 H HB3  . PHE A 1 112 ? -17.86275 -28.47768 21.04807  1.000 34.42757  ? 112 PHE A HB3  1 
ATOM   1752 H HD1  . PHE A 1 112 ? -18.46204 -26.39393 19.93440  1.000 35.68666  ? 112 PHE A HD1  1 
ATOM   1753 H HD2  . PHE A 1 112 ? -15.62353 -28.75288 18.40262  1.000 33.85990  ? 112 PHE A HD2  1 
ATOM   1754 H HE1  . PHE A 1 112 ? -18.55647 -25.21745 17.94816  1.000 34.46495  ? 112 PHE A HE1  1 
ATOM   1755 H HE2  . PHE A 1 112 ? -15.71861 -27.58560 16.42128  1.000 30.35473  ? 112 PHE A HE2  1 
ATOM   1756 H HZ   . PHE A 1 112 ? -17.17851 -25.80951 16.19023  1.000 32.94903  ? 112 PHE A HZ   1 
ATOM   1757 N N    . SER A 1 113 ? -14.00311 -29.10697 21.19681  1.000 26.86604  ? 113 SER A N    1 
ATOM   1758 C CA   . SER A 1 113 ? -12.63015 -29.32882 20.76435  1.000 25.52894  ? 113 SER A CA   1 
ATOM   1759 C C    . SER A 1 113 ? -12.62541 -29.87413 19.34510  1.000 26.24793  ? 113 SER A C    1 
ATOM   1760 O O    . SER A 1 113 ? -13.37690 -30.80202 19.03021  1.000 26.05762  ? 113 SER A O    1 
ATOM   1761 C CB   . SER A 1 113 ? -11.90728 -30.30580 21.69280  1.000 28.11586  ? 113 SER A CB   1 
ATOM   1762 O OG   . SER A 1 113 ? -11.94010 -29.85980 23.03340  1.000 31.71810  ? 113 SER A OG   1 
ATOM   1763 H H    . SER A 1 113 ? -14.40112 -29.82429 21.45497  1.000 32.22629  ? 113 SER A H    1 
ATOM   1764 H HA   . SER A 1 113 ? -12.15436 -28.48365 20.77853  1.000 30.62178  ? 113 SER A HA   1 
ATOM   1765 H HB2  . SER A 1 113 ? -12.34299 -31.17076 21.63897  1.000 33.72608  ? 113 SER A HB2  1 
ATOM   1766 H HB3  . SER A 1 113 ? -10.98260 -30.38193 21.40984  1.000 33.72608  ? 113 SER A HB3  1 
ATOM   1767 H HG   . SER A 1 113 ? -11.77872 -29.03610 23.06618  1.000 38.04876  ? 113 SER A HG   1 
ATOM   1768 N N    . VAL A 1 114 ? -11.77023 -29.30790 18.49860  1.000 27.17968  ? 114 VAL A N    1 
ATOM   1769 C CA   . VAL A 1 114 ? -11.60437 -29.76121 17.12286  1.000 25.39412  ? 114 VAL A CA   1 
ATOM   1770 C C    . VAL A 1 114 ? -10.31939 -30.56914 17.03807  1.000 26.22708  ? 114 VAL A C    1 
ATOM   1771 O O    . VAL A 1 114 ? -9.27204  -30.13642 17.53305  1.000 26.74774  ? 114 VAL A O    1 
ATOM   1772 C CB   . VAL A 1 114 ? -11.57205 -28.57944 16.13844  1.000 25.08984  ? 114 VAL A CB   1 
ATOM   1773 C CG1  . VAL A 1 114 ? -11.15317 -29.05713 14.74952  1.000 24.49193  ? 114 VAL A CG1  1 
ATOM   1774 C CG2  . VAL A 1 114 ? -12.93220 -27.88856 16.07773  1.000 27.22925  ? 114 VAL A CG2  1 
ATOM   1775 H H    . VAL A 1 114 ? -11.26366 -28.64396 18.70398  1.000 32.60266  ? 114 VAL A H    1 
ATOM   1776 H HA   . VAL A 1 114 ? -12.35023 -30.33364 16.88426  1.000 30.45999  ? 114 VAL A HA   1 
ATOM   1777 H HB   . VAL A 1 114 ? -10.92041 -27.93197 16.44996  1.000 30.09485  ? 114 VAL A HB   1 
ATOM   1778 H HG11 . VAL A 1 114 ? -11.59034 -29.90227 14.56107  1.000 29.37737  ? 114 VAL A HG11 1 
ATOM   1779 H HG12 . VAL A 1 114 ? -11.41921 -28.39366 14.09383  1.000 29.37737  ? 114 VAL A HG12 1 
ATOM   1780 H HG13 . VAL A 1 114 ? -10.19013 -29.17176 14.73212  1.000 29.37737  ? 114 VAL A HG13 1 
ATOM   1781 H HG21 . VAL A 1 114 ? -12.83732 -27.04515 15.60810  1.000 32.66215  ? 114 VAL A HG21 1 
ATOM   1782 H HG22 . VAL A 1 114 ? -13.55664 -28.46151 15.60582  1.000 32.66215  ? 114 VAL A HG22 1 
ATOM   1783 H HG23 . VAL A 1 114 ? -13.24665 -27.73032 16.98160  1.000 32.66215  ? 114 VAL A HG23 1 
ATOM   1784 N N    . LEU A 1 115 ? -10.40123 -31.75062 16.42961  1.000 25.88743  ? 115 LEU A N    1 
ATOM   1785 C CA   . LEU A 1 115 ? -9.22308  -32.54193 16.08124  1.000 26.71903  ? 115 LEU A CA   1 
ATOM   1786 C C    . LEU A 1 115 ? -9.01376  -32.39260 14.57782  1.000 25.44772  ? 115 LEU A C    1 
ATOM   1787 O O    . LEU A 1 115 ? -9.65684  -33.07901 13.77839  1.000 27.17283  ? 115 LEU A O    1 
ATOM   1788 C CB   . LEU A 1 115 ? -9.39768  -34.00158 16.48483  1.000 29.30538  ? 115 LEU A CB   1 
ATOM   1789 C CG   . LEU A 1 115 ? -8.22185  -34.92130 16.14083  1.000 29.84219  ? 115 LEU A CG   1 
ATOM   1790 C CD1  . LEU A 1 115 ? -6.95982  -34.48340 16.87991  1.000 26.40576  ? 115 LEU A CD1  1 
ATOM   1791 C CD2  . LEU A 1 115 ? -8.56726  -36.37731 16.44435  1.000 27.45229  ? 115 LEU A CD2  1 
ATOM   1792 H H    . LEU A 1 115 ? -11.14332 -32.12207 16.20396  1.000 31.05197  ? 115 LEU A H    1 
ATOM   1793 H HA   . LEU A 1 115 ? -8.44593  -32.19813 16.54893  1.000 32.04988  ? 115 LEU A HA   1 
ATOM   1794 H HB2  . LEU A 1 115 ? -9.52416  -34.03939 17.44581  1.000 35.15350  ? 115 LEU A HB2  1 
ATOM   1795 H HB3  . LEU A 1 115 ? -10.18152 -34.35139 16.03303  1.000 35.15350  ? 115 LEU A HB3  1 
ATOM   1796 H HG   . LEU A 1 115 ? -8.03907  -34.85834 15.19028  1.000 35.79767  ? 115 LEU A HG   1 
ATOM   1797 H HD11 . LEU A 1 115 ? -6.53009  -33.77340 16.37778  1.000 31.67395  ? 115 LEU A HD11 1 
ATOM   1798 H HD12 . LEU A 1 115 ? -7.20550  -34.16287 17.76184  1.000 31.67395  ? 115 LEU A HD12 1 
ATOM   1799 H HD13 . LEU A 1 115 ? -6.36070  -35.24217 16.95876  1.000 31.67395  ? 115 LEU A HD13 1 
ATOM   1800 H HD21 . LEU A 1 115 ? -9.22595  -36.68599 15.80267  1.000 32.92979  ? 115 LEU A HD21 1 
ATOM   1801 H HD22 . LEU A 1 115 ? -7.76203  -36.91379 16.37588  1.000 32.92979  ? 115 LEU A HD22 1 
ATOM   1802 H HD23 . LEU A 1 115 ? -8.92814  -36.43557 17.34284  1.000 32.92979  ? 115 LEU A HD23 1 
ATOM   1803 N N    . ALA A 1 116 ? -8.12249  -31.48278 14.19392  1.000 25.12196  ? 116 ALA A N    1 
ATOM   1804 C CA   . ALA A 1 116 ? -7.84000  -31.26142 12.78334  1.000 26.50732  ? 116 ALA A CA   1 
ATOM   1805 C C    . ALA A 1 116 ? -7.09333  -32.45970 12.21581  1.000 26.37888  ? 116 ALA A C    1 
ATOM   1806 O O    . ALA A 1 116 ? -6.13312  -32.94836 12.81972  1.000 27.04766  ? 116 ALA A O    1 
ATOM   1807 C CB   . ALA A 1 116 ? -7.01994  -29.98788 12.59370  1.000 27.53428  ? 116 ALA A CB   1 
ATOM   1808 H H    . ALA A 1 116 ? -7.67082  -30.98375 14.72923  1.000 30.13339  ? 116 ALA A H    1 
ATOM   1809 H HA   . ALA A 1 116 ? -8.67328  -31.15294 12.29880  1.000 31.79583  ? 116 ALA A HA   1 
ATOM   1810 H HB1  . ALA A 1 116 ? -7.00489  -29.75939 11.65111  1.000 33.02818  ? 116 ALA A HB1  1 
ATOM   1811 H HB2  . ALA A 1 116 ? -7.42942  -29.27004 13.10157  1.000 33.02818  ? 116 ALA A HB2  1 
ATOM   1812 H HB3  . ALA A 1 116 ? -6.11657  -30.14383 12.91072  1.000 33.02818  ? 116 ALA A HB3  1 
ATOM   1813 N N    . CYS A 1 117 ? -7.53360  -32.93110 11.05245  1.000 23.68525  ? 117 CYS A N    1 
ATOM   1814 C CA   . CYS A 1 117 ? -6.98905  -34.14185 10.45946  1.000 26.14979  ? 117 CYS A CA   1 
ATOM   1815 C C    . CYS A 1 117 ? -6.74242  -33.93239 8.97452   1.000 26.23251  ? 117 CYS A C    1 
ATOM   1816 O O    . CYS A 1 117 ? -7.37182  -33.09094 8.32995   1.000 27.29105  ? 117 CYS A O    1 
ATOM   1817 C CB   . CYS A 1 117 ? -7.92842  -35.33283 10.65314  1.000 26.52570  ? 117 CYS A CB   1 
ATOM   1818 S SG   . CYS A 1 117 ? -8.10841  -35.83042 12.36340  1.000 28.07609  ? 117 CYS A SG   1 
ATOM   1819 H H    . CYS A 1 117 ? -8.15355  -32.56152 10.58482  1.000 28.40935  ? 117 CYS A H    1 
ATOM   1820 H HA   . CYS A 1 117 ? -6.13757  -34.33495 10.88207  1.000 31.36679  ? 117 CYS A HA   1 
ATOM   1821 H HB2  . CYS A 1 117 ? -8.80740  -35.09529 10.31865  1.000 31.81788  ? 117 CYS A HB2  1 
ATOM   1822 H HB3  . CYS A 1 117 ? -7.57878  -36.09040 10.15843  1.000 31.81788  ? 117 CYS A HB3  1 
ATOM   1823 H HG   . CYS A 1 117 ? -8.20006  -37.02580 12.41492  1.000 33.67835  ? 117 CYS A HG   1 
ATOM   1824 N N    . TYR A 1 118 ? -5.80915  -34.71849 8.44279   1.000 29.33564  ? 118 TYR A N    1 
ATOM   1825 C CA   . TYR A 1 118 ? -5.49707  -34.72735 7.01952   1.000 27.71733  ? 118 TYR A CA   1 
ATOM   1826 C C    . TYR A 1 118 ? -5.15333  -36.15247 6.62524   1.000 30.50731  ? 118 TYR A C    1 
ATOM   1827 O O    . TYR A 1 118 ? -4.31183  -36.78974 7.26617   1.000 28.68638  ? 118 TYR A O    1 
ATOM   1828 C CB   . TYR A 1 118 ? -4.34209  -33.77590 6.69492   1.000 28.74535  ? 118 TYR A CB   1 
ATOM   1829 C CG   . TYR A 1 118 ? -4.69378  -32.33799 6.96004   1.000 30.33924  ? 118 TYR A CG   1 
ATOM   1830 C CD1  . TYR A 1 118 ? -5.37502  -31.58698 6.01069   1.000 29.34230  ? 118 TYR A CD1  1 
ATOM   1831 C CD2  . TYR A 1 118 ? -4.36980  -31.73426 8.16949   1.000 31.62119  ? 118 TYR A CD2  1 
ATOM   1832 C CE1  . TYR A 1 118 ? -5.70995  -30.27348 6.24988   1.000 29.06008  ? 118 TYR A CE1  1 
ATOM   1833 C CE2  . TYR A 1 118 ? -4.70320  -30.41832 8.42115   1.000 31.65048  ? 118 TYR A CE2  1 
ATOM   1834 C CZ   . TYR A 1 118 ? -5.37558  -29.69320 7.45892   1.000 30.24398  ? 118 TYR A CZ   1 
ATOM   1835 O OH   . TYR A 1 118 ? -5.71158  -28.38273 7.70513   1.000 30.97825  ? 118 TYR A OH   1 
ATOM   1836 H H    . TYR A 1 118 ? -5.33172  -35.26922 8.89924   1.000 35.18982  ? 118 TYR A H    1 
ATOM   1837 H HA   . TYR A 1 118 ? -6.26489  -34.43776 6.50234   1.000 33.24784  ? 118 TYR A HA   1 
ATOM   1838 H HB2  . TYR A 1 118 ? -3.57717  -34.00614 7.24518   1.000 34.48146  ? 118 TYR A HB2  1 
ATOM   1839 H HB3  . TYR A 1 118 ? -4.11369  -33.86283 5.75622   1.000 34.48146  ? 118 TYR A HB3  1 
ATOM   1840 H HD1  . TYR A 1 118 ? -5.60873  -31.97812 5.19995   1.000 35.19780  ? 118 TYR A HD1  1 
ATOM   1841 H HD2  . TYR A 1 118 ? -3.92110  -32.22480 8.81983   1.000 37.93248  ? 118 TYR A HD2  1 
ATOM   1842 H HE1  . TYR A 1 118 ? -6.15845  -29.77954 5.60198   1.000 34.85914  ? 118 TYR A HE1  1 
ATOM   1843 H HE2  . TYR A 1 118 ? -4.47651  -30.02400 9.23233   1.000 37.96762  ? 118 TYR A HE2  1 
ATOM   1844 H HH   . TYR A 1 118 ? -5.56373  -28.19464 8.51034   1.000 37.16095  ? 118 TYR A HH   1 
ATOM   1845 N N    . ASN A 1 119 ? -5.82841  -36.65844 5.59317   1.000 29.60637  ? 119 ASN A N    1 
ATOM   1846 C CA   . ASN A 1 119 ? -5.60194  -38.01521 5.10704   1.000 31.71785  ? 119 ASN A CA   1 
ATOM   1847 C C    . ASN A 1 119 ? -5.87455  -39.04812 6.19177   1.000 30.52850  ? 119 ASN A C    1 
ATOM   1848 O O    . ASN A 1 119 ? -5.21875  -40.09089 6.24691   1.000 29.42297  ? 119 ASN A O    1 
ATOM   1849 C CB   . ASN A 1 119 ? -4.17794  -38.17273 4.57130   1.000 32.16581  ? 119 ASN A CB   1 
ATOM   1850 C CG   . ASN A 1 119 ? -3.86682  -37.19577 3.45563   1.000 36.73518  ? 119 ASN A CG   1 
ATOM   1851 O OD1  . ASN A 1 119 ? -2.92741  -36.40655 3.55147   1.000 42.11132  ? 119 ASN A OD1  1 
ATOM   1852 N ND2  . ASN A 1 119 ? -4.66234  -37.23606 2.39424   1.000 37.87646  ? 119 ASN A ND2  1 
ATOM   1853 H H    . ASN A 1 119 ? -6.42987  -36.22841 5.15394   1.000 35.51469  ? 119 ASN A H    1 
ATOM   1854 H HA   . ASN A 1 119 ? -6.21925  -38.18711 4.37883   1.000 38.04846  ? 119 ASN A HA   1 
ATOM   1855 H HB2  . ASN A 1 119 ? -3.54863  -38.01625 5.29267   1.000 38.58602  ? 119 ASN A HB2  1 
ATOM   1856 H HB3  . ASN A 1 119 ? -4.06749  -39.07160 4.22383   1.000 38.58602  ? 119 ASN A HB3  1 
ATOM   1857 H HD21 . ASN A 1 119 ? -4.52660  -36.70124 1.73459   1.000 45.43879  ? 119 ASN A HD21 1 
ATOM   1858 H HD22 . ASN A 1 119 ? -5.31362  -37.79698 2.36606   1.000 45.43879  ? 119 ASN A HD22 1 
ATOM   1859 N N    . GLY A 1 120 ? -6.84241  -38.76012 7.06251   1.000 28.76823  ? 120 GLY A N    1 
ATOM   1860 C CA   . GLY A 1 120 ? -7.18410  -39.65482 8.14531   1.000 28.24154  ? 120 GLY A CA   1 
ATOM   1861 C C    . GLY A 1 120 ? -6.22389  -39.64754 9.31330   1.000 28.90679  ? 120 GLY A C    1 
ATOM   1862 O O    . GLY A 1 120 ? -6.38278  -40.46655 10.22689  1.000 29.92087  ? 120 GLY A O    1 
ATOM   1863 H H    . GLY A 1 120 ? -7.31624  -38.04277 7.04024   1.000 34.50893  ? 120 GLY A H    1 
ATOM   1864 H HA2  . GLY A 1 120 ? -8.06025  -39.41131 8.48290   1.000 33.87689  ? 120 GLY A HA2  1 
ATOM   1865 H HA3  . GLY A 1 120 ? -7.21956  -40.56016 7.79892   1.000 33.87689  ? 120 GLY A HA3  1 
ATOM   1866 N N    . SER A 1 121 ? -5.23347  -38.75516 9.31678   1.000 27.37615  ? 121 SER A N    1 
ATOM   1867 C CA   . SER A 1 121 ? -4.24489  -38.69797 10.38216  1.000 29.53697  ? 121 SER A CA   1 
ATOM   1868 C C    . SER A 1 121 ? -4.42795  -37.43618 11.20963  1.000 31.69685  ? 121 SER A C    1 
ATOM   1869 O O    . SER A 1 121 ? -4.47542  -36.33523 10.64361  1.000 28.76959  ? 121 SER A O    1 
ATOM   1870 C CB   . SER A 1 121 ? -2.82737  -38.72869 9.80612   1.000 30.45306  ? 121 SER A CB   1 
ATOM   1871 O OG   . SER A 1 121 ? -2.51412  -40.01954 9.32352   1.000 39.63402  ? 121 SER A OG   1 
ATOM   1872 H H    . SER A 1 121 ? -5.11481  -38.16546 8.70215   1.000 32.83843  ? 121 SER A H    1 
ATOM   1873 H HA   . SER A 1 121 ? -4.36219  -39.46750 10.96092  1.000 35.43141  ? 121 SER A HA   1 
ATOM   1874 H HB2  . SER A 1 121 ? -2.76903  -38.09436 9.07460   1.000 36.53072  ? 121 SER A HB2  1 
ATOM   1875 H HB3  . SER A 1 121 ? -2.19693  -38.48974 10.50351  1.000 36.53072  ? 121 SER A HB3  1 
ATOM   1876 H HG   . SER A 1 121 ? -3.01877  -40.21654 8.68155   1.000 47.54787  ? 121 SER A HG   1 
ATOM   1877 N N    . PRO A 1 122 ? -4.51671  -37.54246 12.53484  1.000 32.95368  ? 122 PRO A N    1 
ATOM   1878 C CA   . PRO A 1 122 ? -4.65734  -36.33404 13.35690  1.000 32.43857  ? 122 PRO A CA   1 
ATOM   1879 C C    . PRO A 1 122 ? -3.45700  -35.41228 13.20829  1.000 34.23747  ? 122 PRO A C    1 
ATOM   1880 O O    . PRO A 1 122 ? -2.30384  -35.84663 13.26604  1.000 37.19948  ? 122 PRO A O    1 
ATOM   1881 C CB   . PRO A 1 122 ? -4.77694  -36.88885 14.78181  1.000 33.35773  ? 122 PRO A CB   1 
ATOM   1882 C CG   . PRO A 1 122 ? -5.28258  -38.28086 14.60020  1.000 34.80897  ? 122 PRO A CG   1 
ATOM   1883 C CD   . PRO A 1 122 ? -4.61580  -38.76722 13.35015  1.000 32.67390  ? 122 PRO A CD   1 
ATOM   1884 H HA   . PRO A 1 122 ? -5.46539  -35.85248 13.12013  1.000 38.91333  ? 122 PRO A HA   1 
ATOM   1885 H HB2  . PRO A 1 122 ? -3.90804  -36.88678 15.21298  1.000 40.01632  ? 122 PRO A HB2  1 
ATOM   1886 H HB3  . PRO A 1 122 ? -5.40312  -36.35438 15.29478  1.000 40.01632  ? 122 PRO A HB3  1 
ATOM   1887 H HG2  . PRO A 1 122 ? -5.03315  -38.82662 15.36232  1.000 41.75780  ? 122 PRO A HG2  1 
ATOM   1888 H HG3  . PRO A 1 122 ? -6.24729  -38.27301 14.49930  1.000 41.75780  ? 122 PRO A HG3  1 
ATOM   1889 H HD2  . PRO A 1 122 ? -3.73622  -39.12752 13.54359  1.000 39.19573  ? 122 PRO A HD2  1 
ATOM   1890 H HD3  . PRO A 1 122 ? -5.15833  -39.43720 12.90552  1.000 39.19573  ? 122 PRO A HD3  1 
ATOM   1891 N N    . SER A 1 123 ? -3.74278  -34.12480 13.02066  1.000 32.62322  ? 123 SER A N    1 
ATOM   1892 C CA   . SER A 1 123 ? -2.72805  -33.09095 12.87404  1.000 33.72209  ? 123 SER A CA   1 
ATOM   1893 C C    . SER A 1 123 ? -2.54951  -32.25271 14.13275  1.000 35.08620  ? 123 SER A C    1 
ATOM   1894 O O    . SER A 1 123 ? -1.41482  -31.95688 14.52013  1.000 34.78230  ? 123 SER A O    1 
ATOM   1895 C CB   . SER A 1 123 ? -3.08748  -32.17290 11.70266  1.000 36.06619  ? 123 SER A CB   1 
ATOM   1896 O OG   . SER A 1 123 ? -2.19885  -31.07215 11.62332  1.000 42.14247  ? 123 SER A OG   1 
ATOM   1897 H H    . SER A 1 123 ? -4.54488  -33.81819 12.97359  1.000 39.13491  ? 123 SER A H    1 
ATOM   1898 H HA   . SER A 1 123 ? -1.87677  -33.51217 12.67711  1.000 40.45356  ? 123 SER A HA   1 
ATOM   1899 H HB2  . SER A 1 123 ? -3.03391  -32.68027 10.87767  1.000 43.26647  ? 123 SER A HB2  1 
ATOM   1900 H HB3  . SER A 1 123 ? -3.98972  -31.84006 11.82945  1.000 43.26647  ? 123 SER A HB3  1 
ATOM   1901 H HG   . SER A 1 123 ? -1.41761  -31.34361 11.47649  1.000 50.55801  ? 123 SER A HG   1 
ATOM   1902 N N    . GLY A 1 124 ? -3.64072  -31.86352 14.77964  1.000 29.42314  ? 124 GLY A N    1 
ATOM   1903 C CA   . GLY A 1 124 ? -3.55488  -31.05478 15.98011  1.000 28.44507  ? 124 GLY A CA   1 
ATOM   1904 C C    . GLY A 1 124 ? -4.94768  -30.81134 16.51112  1.000 28.49891  ? 124 GLY A C    1 
ATOM   1905 O O    . GLY A 1 124 ? -5.94990  -31.07233 15.83720  1.000 28.49267  ? 124 GLY A O    1 
ATOM   1906 H H    . GLY A 1 124 ? -4.44412  -32.05647 14.54106  1.000 35.29482  ? 124 GLY A H    1 
ATOM   1907 H HA2  . GLY A 1 124 ? -3.03137  -31.51340 16.65576  1.000 34.12113  ? 124 GLY A HA2  1 
ATOM   1908 H HA3  . GLY A 1 124 ? -3.13606  -30.20295 15.78042  1.000 34.12113  ? 124 GLY A HA3  1 
ATOM   1909 N N    . VAL A 1 125 ? -4.99983  -30.30602 17.73759  1.000 26.58422  ? 125 VAL A N    1 
ATOM   1910 C CA   . VAL A 1 125 ? -6.26158  -30.11904 18.43940  1.000 27.34256  ? 125 VAL A CA   1 
ATOM   1911 C C    . VAL A 1 125 ? -6.30869  -28.72102 19.03737  1.000 26.93221  ? 125 VAL A C    1 
ATOM   1912 O O    . VAL A 1 125 ? -5.29597  -28.19580 19.51676  1.000 24.83738  ? 125 VAL A O    1 
ATOM   1913 C CB   . VAL A 1 125 ? -6.46408  -31.19924 19.52368  1.000 27.04085  ? 125 VAL A CB   1 
ATOM   1914 C CG1  . VAL A 1 125 ? -5.32146  -31.18156 20.51340  1.000 30.07089  ? 125 VAL A CG1  1 
ATOM   1915 C CG2  . VAL A 1 125 ? -7.79284  -31.01035 20.22549  1.000 29.87245  ? 125 VAL A CG2  1 
ATOM   1916 H H    . VAL A 1 125 ? -4.30922  -30.06156 18.18804  1.000 31.88811  ? 125 VAL A H    1 
ATOM   1917 H HA   . VAL A 1 125 ? -6.99141  -30.18169 17.80354  1.000 32.79812  ? 125 VAL A HA   1 
ATOM   1918 H HB   . VAL A 1 125 ? -6.47499  -32.07067 19.09778  1.000 32.43606  ? 125 VAL A HB   1 
ATOM   1919 H HG11 . VAL A 1 125 ? -4.48227  -31.17944 20.02692  1.000 36.07211  ? 125 VAL A HG11 1 
ATOM   1920 H HG12 . VAL A 1 125 ? -5.38915  -30.38286 21.05966  1.000 36.07211  ? 125 VAL A HG12 1 
ATOM   1921 H HG13 . VAL A 1 125 ? -5.37689  -31.97131 21.07387  1.000 36.07211  ? 125 VAL A HG13 1 
ATOM   1922 H HG21 . VAL A 1 125 ? -8.40754  -30.56328 19.62286  1.000 35.83398  ? 125 VAL A HG21 1 
ATOM   1923 H HG22 . VAL A 1 125 ? -8.14558  -31.87938 20.47303  1.000 35.83398  ? 125 VAL A HG22 1 
ATOM   1924 H HG23 . VAL A 1 125 ? -7.65658  -30.47025 21.01961  1.000 35.83398  ? 125 VAL A HG23 1 
ATOM   1925 N N    . TYR A 1 126 ? -7.49346  -28.11684 18.99634  1.000 27.66730  ? 126 TYR A N    1 
ATOM   1926 C CA   . TYR A 1 126 ? -7.70306  -26.77903 19.52697  1.000 28.99296  ? 126 TYR A CA   1 
ATOM   1927 C C    . TYR A 1 126 ? -9.17980  -26.60704 19.85315  1.000 27.19548  ? 126 TYR A C    1 
ATOM   1928 O O    . TYR A 1 126 ? -10.03621 -27.33783 19.34872  1.000 27.10790  ? 126 TYR A O    1 
ATOM   1929 C CB   . TYR A 1 126 ? -7.23143  -25.70988 18.53704  1.000 27.40922  ? 126 TYR A CB   1 
ATOM   1930 C CG   . TYR A 1 126 ? -7.77137  -25.89347 17.13740  1.000 27.42310  ? 126 TYR A CG   1 
ATOM   1931 C CD1  . TYR A 1 126 ? -9.01242  -25.39434 16.78106  1.000 29.90917  ? 126 TYR A CD1  1 
ATOM   1932 C CD2  . TYR A 1 126 ? -7.03535  -26.56534 16.17141  1.000 28.80216  ? 126 TYR A CD2  1 
ATOM   1933 C CE1  . TYR A 1 126 ? -9.50934  -25.56194 15.50284  1.000 27.59042  ? 126 TYR A CE1  1 
ATOM   1934 C CE2  . TYR A 1 126 ? -7.52046  -26.73610 14.89278  1.000 24.85326  ? 126 TYR A CE2  1 
ATOM   1935 C CZ   . TYR A 1 126 ? -8.75752  -26.23375 14.56174  1.000 27.93516  ? 126 TYR A CZ   1 
ATOM   1936 O OH   . TYR A 1 126 ? -9.24277  -26.40271 13.28531  1.000 27.74360  ? 126 TYR A OH   1 
ATOM   1937 H H    . TYR A 1 126 ? -8.20232  -28.46895 18.65997  1.000 33.18781  ? 126 TYR A H    1 
ATOM   1938 H HA   . TYR A 1 126 ? -7.20152  -26.67305 20.35046  1.000 34.77860  ? 126 TYR A HA   1 
ATOM   1939 H HB2  . TYR A 1 126 ? -7.52254  -24.84086 18.85479  1.000 32.87811  ? 126 TYR A HB2  1 
ATOM   1940 H HB3  . TYR A 1 126 ? -6.26314  -25.73737 18.48655  1.000 32.87811  ? 126 TYR A HB3  1 
ATOM   1941 H HD1  . TYR A 1 126 ? -9.52033  -24.93846 17.41281  1.000 35.87805  ? 126 TYR A HD1  1 
ATOM   1942 H HD2  . TYR A 1 126 ? -6.19872  -26.90689 16.39117  1.000 34.54964  ? 126 TYR A HD2  1 
ATOM   1943 H HE1  . TYR A 1 126 ? -10.34603 -25.22366 15.27829  1.000 33.09555  ? 126 TYR A HE1  1 
ATOM   1944 H HE2  . TYR A 1 126 ? -7.01421  -27.18850 14.25721  1.000 29.81096  ? 126 TYR A HE2  1 
ATOM   1945 H HH   . TYR A 1 126 ? -9.99624  -26.03833 13.21382  1.000 33.27937  ? 126 TYR A HH   1 
ATOM   1946 N N    . GLN A 1 127 ? -9.46258  -25.61747 20.69690  1.000 26.64352  ? 127 GLN A N    1 
ATOM   1947 C CA   . GLN A 1 127 ? -10.80127 -25.36492 21.21186  1.000 29.45912  ? 127 GLN A CA   1 
ATOM   1948 C C    . GLN A 1 127 ? -11.49158 -24.29095 20.37968  1.000 30.66636  ? 127 GLN A C    1 
ATOM   1949 O O    . GLN A 1 127 ? -10.87554 -23.28891 20.00730  1.000 32.12719  ? 127 GLN A O    1 
ATOM   1950 C CB   . GLN A 1 127 ? -10.72749 -24.92792 22.67824  1.000 30.09025  ? 127 GLN A CB   1 
ATOM   1951 C CG   . GLN A 1 127 ? -12.05037 -24.95557 23.42405  1.000 31.82905  ? 127 GLN A CG   1 
ATOM   1952 C CD   . GLN A 1 127 ? -12.43672 -26.34361 23.88791  1.000 29.58475  ? 127 GLN A CD   1 
ATOM   1953 O OE1  . GLN A 1 127 ? -11.96583 -27.34738 23.35080  1.000 29.81115  ? 127 GLN A OE1  1 
ATOM   1954 N NE2  . GLN A 1 127 ? -13.29681 -26.40909 24.89751  1.000 31.94204  ? 127 GLN A NE2  1 
ATOM   1955 H H    . GLN A 1 127 ? -8.87597  -25.06292 20.99348  1.000 31.95927  ? 127 GLN A H    1 
ATOM   1956 H HA   . GLN A 1 127 ? -11.33449 -26.17317 21.15437  1.000 35.33799  ? 127 GLN A HA   1 
ATOM   1957 H HB2  . GLN A 1 127 ? -10.11815 -25.52104 23.14495  1.000 36.09535  ? 127 GLN A HB2  1 
ATOM   1958 H HB3  . GLN A 1 127 ? -10.39435 -24.01751 22.71078  1.000 36.09535  ? 127 GLN A HB3  1 
ATOM   1959 H HG2  . GLN A 1 127 ? -11.98326 -24.38640 24.20664  1.000 38.18190  ? 127 GLN A HG2  1 
ATOM   1960 H HG3  . GLN A 1 127 ? -12.75055 -24.63068 22.83660  1.000 38.18190  ? 127 GLN A HG3  1 
ATOM   1961 H HE21 . GLN A 1 127 ? -13.60195 -25.68642 25.25000  1.000 38.31749  ? 127 GLN A HE21 1 
ATOM   1962 H HE22 . GLN A 1 127 ? -13.54871 -27.17415 25.19887  1.000 38.31749  ? 127 GLN A HE22 1 
ATOM   1963 N N    . CYS A 1 128 ? -12.77370 -24.50627 20.09052  1.000 31.55136  ? 128 CYS A N    1 
ATOM   1964 C CA   . CYS A 1 128 ? -13.59554 -23.55729 19.35278  1.000 30.33542  ? 128 CYS A CA   1 
ATOM   1965 C C    . CYS A 1 128 ? -14.90891 -23.32896 20.08907  1.000 29.57223  ? 128 CYS A C    1 
ATOM   1966 O O    . CYS A 1 128 ? -15.28206 -24.07853 20.99485  1.000 29.58873  ? 128 CYS A O    1 
ATOM   1967 C CB   . CYS A 1 128 ? -13.89992 -24.05011 17.93201  1.000 30.05058  ? 128 CYS A CB   1 
ATOM   1968 S SG   . CYS A 1 128 ? -12.53540 -23.94186 16.77867  1.000 34.83187  ? 128 CYS A SG   1 
ATOM   1969 H H    . CYS A 1 128 ? -13.20000 -25.21727 20.31931  1.000 37.84868  ? 128 CYS A H    1 
ATOM   1970 H HA   . CYS A 1 128 ? -13.11321 -22.71740 19.29942  1.000 36.38955  ? 128 CYS A HA   1 
ATOM   1971 H HB2  . CYS A 1 128 ? -14.16459 -24.98200 17.98146  1.000 36.04774  ? 128 CYS A HB2  1 
ATOM   1972 H HB3  . CYS A 1 128 ? -14.62651 -23.51750 17.57243  1.000 36.04774  ? 128 CYS A HB3  1 
ATOM   1973 H HG   . CYS A 1 128 ? -12.26857 -22.78617 16.59651  1.000 41.78529  ? 128 CYS A HG   1 
ATOM   1974 N N    . ALA A 1 129 ? -15.60727 -22.27379 19.67970  1.000 27.48174  ? 129 ALA A N    1 
ATOM   1975 C CA   . ALA A 1 129 ? -16.96558 -21.99326 20.11446  1.000 28.63460  ? 129 ALA A CA   1 
ATOM   1976 C C    . ALA A 1 129 ? -17.85819 -21.89293 18.88583  1.000 27.69751  ? 129 ALA A C    1 
ATOM   1977 O O    . ALA A 1 129 ? -17.42830 -21.41166 17.83419  1.000 24.91731  ? 129 ALA A O    1 
ATOM   1978 C CB   . ALA A 1 129 ? -17.04416 -20.69061 20.92638  1.000 28.77950  ? 129 ALA A CB   1 
ATOM   1979 H H    . ALA A 1 129 ? -15.30165 -21.68697 19.13030  1.000 32.96514  ? 129 ALA A H    1 
ATOM   1980 H HA   . ALA A 1 129 ? -17.28478 -22.71154 20.68287  1.000 34.34856  ? 129 ALA A HA   1 
ATOM   1981 H HB1  . ALA A 1 129 ? -16.50507 -20.78467 21.72728  1.000 34.52245  ? 129 ALA A HB1  1 
ATOM   1982 H HB2  . ALA A 1 129 ? -16.70704 -19.96001 20.38465  1.000 34.52245  ? 129 ALA A HB2  1 
ATOM   1983 H HB3  . ALA A 1 129 ? -17.96881 -20.52418 21.16769  1.000 34.52245  ? 129 ALA A HB3  1 
ATOM   1984 N N    . MET A 1 130 ? -19.09362 -22.36674 19.01505  1.000 25.44971  ? 130 MET A N    1 
ATOM   1985 C CA   . MET A 1 130 ? -20.11242 -22.10616 18.00479  1.000 26.52448  ? 130 MET A CA   1 
ATOM   1986 C C    . MET A 1 130 ? -20.57675 -20.66732 18.18056  1.000 29.59626  ? 130 MET A C    1 
ATOM   1987 O O    . MET A 1 130 ? -21.21918 -20.33135 19.18025  1.000 32.13599  ? 130 MET A O    1 
ATOM   1988 C CB   . MET A 1 130 ? -21.27519 -23.08169 18.13672  1.000 27.56677  ? 130 MET A CB   1 
ATOM   1989 C CG   . MET A 1 130 ? -22.38158 -22.88173 17.10900  1.000 33.02864  ? 130 MET A CG   1 
ATOM   1990 S SD   . MET A 1 130 ? -21.80704 -22.96582 15.39760  1.000 29.60973  ? 130 MET A SD   1 
ATOM   1991 C CE   . MET A 1 130 ? -21.11479 -24.60936 15.35238  1.000 25.11325  ? 130 MET A CE   1 
ATOM   1992 H H    . MET A 1 130 ? -19.36586 -22.84145 19.67848  1.000 30.52669  ? 130 MET A H    1 
ATOM   1993 H HA   . MET A 1 130 ? -19.73431 -22.23145 17.12035  1.000 31.81642  ? 130 MET A HA   1 
ATOM   1994 H HB2  . MET A 1 130 ? -20.93569 -23.98417 18.03100  1.000 33.06717  ? 130 MET A HB2  1 
ATOM   1995 H HB3  . MET A 1 130 ? -21.66927 -22.97646 19.01679  1.000 33.06717  ? 130 MET A HB3  1 
ATOM   1996 H HG2  . MET A 1 130 ? -23.05022 -23.57377 17.23106  1.000 39.62141  ? 130 MET A HG2  1 
ATOM   1997 H HG3  . MET A 1 130 ? -22.77999 -22.00782 17.24484  1.000 39.62141  ? 130 MET A HG3  1 
ATOM   1998 H HE1  . MET A 1 130 ? -20.85441 -24.81740 14.44144  1.000 30.12294  ? 130 MET A HE1  1 
ATOM   1999 H HE2  . MET A 1 130 ? -20.33892 -24.64134 15.93368  1.000 30.12294  ? 130 MET A HE2  1 
ATOM   2000 H HE3  . MET A 1 130 ? -21.78341 -25.24216 15.65801  1.000 30.12294  ? 130 MET A HE3  1 
ATOM   2001 N N    . ARG A 1 131 ? -20.24623 -19.81802 17.22503  1.000 28.52303  ? 131 ARG A N    1 
ATOM   2002 C CA   . ARG A 1 131 ? -20.47701 -18.39729 17.38996  1.000 31.37447  ? 131 ARG A CA   1 
ATOM   2003 C C    . ARG A 1 131 ? -21.92709 -18.04220 17.08104  1.000 34.13602  ? 131 ARG A C    1 
ATOM   2004 O O    . ARG A 1 131 ? -22.62595 -18.78434 16.38462  1.000 33.94556  ? 131 ARG A O    1 
ATOM   2005 C CB   . ARG A 1 131 ? -19.52574 -17.61623 16.49311  1.000 31.82260  ? 131 ARG A CB   1 
ATOM   2006 C CG   . ARG A 1 131 ? -18.05767 -17.93075 16.77946  1.000 33.09205  ? 131 ARG A CG   1 
ATOM   2007 C CD   . ARG A 1 131 ? -17.13749 -16.78565 16.40545  1.000 34.34451  ? 131 ARG A CD   1 
ATOM   2008 N NE   . ARG A 1 131 ? -17.54723 -15.54295 17.04640  1.000 35.36808  ? 131 ARG A NE   1 
ATOM   2009 C CZ   . ARG A 1 131 ? -17.32260 -15.24143 18.31803  1.000 34.22072  ? 131 ARG A CZ   1 
ATOM   2010 N NH1  . ARG A 1 131 ? -16.65935 -16.06124 19.11715  1.000 32.66470  ? 131 ARG A NH1  1 
ATOM   2011 N NH2  . ARG A 1 131 ? -17.78043 -14.09002 18.80097  1.000 32.89602  ? 131 ARG A NH2  1 
ATOM   2012 H H    . ARG A 1 131 ? -19.88836 -20.03874 16.47483  1.000 34.21468  ? 131 ARG A H    1 
ATOM   2013 H HA   . ARG A 1 131 ? -20.30453 -18.13846 18.30874  1.000 37.63641  ? 131 ARG A HA   1 
ATOM   2014 H HB2  . ARG A 1 131 ? -19.70697 -17.84182 15.56728  1.000 38.17417  ? 131 ARG A HB2  1 
ATOM   2015 H HB3  . ARG A 1 131 ? -19.66377 -16.66685 16.63639  1.000 38.17417  ? 131 ARG A HB3  1 
ATOM   2016 H HG2  . ARG A 1 131 ? -17.94935 -18.10665 17.72720  1.000 39.69750  ? 131 ARG A HG2  1 
ATOM   2017 H HG3  . ARG A 1 131 ? -17.79334 -18.70954 16.26515  1.000 39.69750  ? 131 ARG A HG3  1 
ATOM   2018 H HD2  . ARG A 1 131 ? -16.23391 -16.99304 16.69080  1.000 41.20045  ? 131 ARG A HD2  1 
ATOM   2019 H HD3  . ARG A 1 131 ? -17.16032 -16.65566 15.44447  1.000 41.20045  ? 131 ARG A HD3  1 
ATOM   2020 H HE   . ARG A 1 131 ? -17.96419 -14.96413 16.56608  1.000 42.42875  ? 131 ARG A HE   1 
ATOM   2021 H HH11 . ARG A 1 131 ? -16.36261 -16.80972 18.81496  1.000 39.18469  ? 131 ARG A HH11 1 
ATOM   2022 H HH12 . ARG A 1 131 ? -16.52498 -15.84562 19.93877  1.000 39.18469  ? 131 ARG A HH12 1 
ATOM   2023 H HH21 . ARG A 1 131 ? -18.21577 -13.55225 18.29022  1.000 39.46227  ? 131 ARG A HH21 1 
ATOM   2024 H HH22 . ARG A 1 131 ? -17.64115 -13.88321 19.62403  1.000 39.46227  ? 131 ARG A HH22 1 
ATOM   2025 N N    . PRO A 1 132 ? -22.40978 -16.91138 17.60958  1.000 34.39974  ? 132 PRO A N    1 
ATOM   2026 C CA   . PRO A 1 132 ? -23.80650 -16.51758 17.36103  1.000 33.77902  ? 132 PRO A CA   1 
ATOM   2027 C C    . PRO A 1 132 ? -24.22702 -16.57327 15.90332  1.000 34.87111  ? 132 PRO A C    1 
ATOM   2028 O O    . PRO A 1 132 ? -25.39544 -16.87757 15.62903  1.000 35.53767  ? 132 PRO A O    1 
ATOM   2029 C CB   . PRO A 1 132 ? -23.85393 -15.08506 17.91327  1.000 36.80882  ? 132 PRO A CB   1 
ATOM   2030 C CG   . PRO A 1 132 ? -22.88586 -15.12587 19.05984  1.000 35.53048  ? 132 PRO A CG   1 
ATOM   2031 C CD   . PRO A 1 132 ? -21.75291 -16.01418 18.57991  1.000 32.62382  ? 132 PRO A CD   1 
ATOM   2032 H HA   . PRO A 1 132 ? -24.40071 -17.08815 17.87314  1.000 40.52186  ? 132 PRO A HA   1 
ATOM   2033 H HB2  . PRO A 1 132 ? -23.57130 -14.45248 17.23441  1.000 44.15762  ? 132 PRO A HB2  1 
ATOM   2034 H HB3  . PRO A 1 132 ? -24.75026 -14.86953 18.21498  1.000 44.15762  ? 132 PRO A HB3  1 
ATOM   2035 H HG2  . PRO A 1 132 ? -22.56653 -14.23116 19.25588  1.000 42.62363  ? 132 PRO A HG2  1 
ATOM   2036 H HG3  . PRO A 1 132 ? -23.31561 -15.50377 19.84305  1.000 42.62363  ? 132 PRO A HG3  1 
ATOM   2037 H HD2  . PRO A 1 132 ? -21.06082 -15.48816 18.14956  1.000 39.13564  ? 132 PRO A HD2  1 
ATOM   2038 H HD3  . PRO A 1 132 ? -21.37544 -16.51993 19.31655  1.000 39.13564  ? 132 PRO A HD3  1 
ATOM   2039 N N    . ASN A 1 133 ? -23.33193 -16.28794 14.95764  1.000 32.45094  ? 133 ASN A N    1 
ATOM   2040 C CA   . ASN A 1 133 ? -23.67136 -16.36634 13.54200  1.000 30.06030  ? 133 ASN A CA   1 
ATOM   2041 C C    . ASN A 1 133 ? -23.39821 -17.74799 12.95121  1.000 33.14703  ? 133 ASN A C    1 
ATOM   2042 O O    . ASN A 1 133 ? -23.35532 -17.88909 11.72391  1.000 33.53136  ? 133 ASN A O    1 
ATOM   2043 C CB   . ASN A 1 133 ? -22.91688 -15.29435 12.74958  1.000 34.08054  ? 133 ASN A CB   1 
ATOM   2044 C CG   . ASN A 1 133 ? -21.42446 -15.53913 12.70329  1.000 33.20986  ? 133 ASN A CG   1 
ATOM   2045 O OD1  . ASN A 1 133 ? -20.92724 -16.52146 13.25534  1.000 31.77187  ? 133 ASN A OD1  1 
ATOM   2046 N ND2  . ASN A 1 133 ? -20.69980 -14.64850 12.03262  1.000 34.20380  ? 133 ASN A ND2  1 
ATOM   2047 H H    . ASN A 1 133 ? -22.52144 -16.04658 15.11398  1.000 38.92818  ? 133 ASN A H    1 
ATOM   2048 H HA   . ASN A 1 133 ? -24.61876 -16.18340 13.44268  1.000 36.05941  ? 133 ASN A HA   1 
ATOM   2049 H HB2  . ASN A 1 133 ? -23.24726 -15.28481 11.83763  1.000 40.88370  ? 133 ASN A HB2  1 
ATOM   2050 H HB3  . ASN A 1 133 ? -23.06599 -14.43082 13.16551  1.000 40.88370  ? 133 ASN A HB3  1 
ATOM   2051 H HD21 . ASN A 1 133 ? -19.84679 -14.74262 11.97676  1.000 41.03161  ? 133 ASN A HD21 1 
ATOM   2052 H HD22 . ASN A 1 133 ? -21.08413 -13.97836 11.65473  1.000 41.03161  ? 133 ASN A HD22 1 
ATOM   2053 N N    . PHE A 1 134 ? -23.19790 -18.75853 13.80011  1.000 33.18859  ? 134 PHE A N    1 
ATOM   2054 C CA   . PHE A 1 134 ? -23.10108 -20.16026 13.38204  1.000 33.67168  ? 134 PHE A CA   1 
ATOM   2055 C C    . PHE A 1 134 ? -21.89270 -20.42145 12.48736  1.000 32.58494  ? 134 PHE A C    1 
ATOM   2056 O O    . PHE A 1 134 ? -21.93915 -21.27303 11.59383  1.000 29.08135  ? 134 PHE A O    1 
ATOM   2057 C CB   . PHE A 1 134 ? -24.39261 -20.61601 12.69689  1.000 30.88557  ? 134 PHE A CB   1 
ATOM   2058 C CG   . PHE A 1 134 ? -25.59331 -20.56033 13.59693  1.000 31.52137  ? 134 PHE A CG   1 
ATOM   2059 C CD1  . PHE A 1 134 ? -25.79753 -21.53353 14.56127  1.000 33.27434  ? 134 PHE A CD1  1 
ATOM   2060 C CD2  . PHE A 1 134 ? -26.50715 -19.52696 13.48898  1.000 33.84358  ? 134 PHE A CD2  1 
ATOM   2061 C CE1  . PHE A 1 134 ? -26.89760 -21.47921 15.39899  1.000 37.01533  ? 134 PHE A CE1  1 
ATOM   2062 C CE2  . PHE A 1 134 ? -27.60665 -19.46675 14.32332  1.000 34.75346  ? 134 PHE A CE2  1 
ATOM   2063 C CZ   . PHE A 1 134 ? -27.80197 -20.44373 15.27816  1.000 36.83756  ? 134 PHE A CZ   1 
ATOM   2064 H H    . PHE A 1 134 ? -23.11216 -18.65509 14.64955  1.000 39.81336  ? 134 PHE A H    1 
ATOM   2065 H HA   . PHE A 1 134 ? -22.97333 -20.70033 14.17760  1.000 40.39306  ? 134 PHE A HA   1 
ATOM   2066 H HB2  . PHE A 1 134 ? -24.56389 -20.04006 11.93542  1.000 37.04974  ? 134 PHE A HB2  1 
ATOM   2067 H HB3  . PHE A 1 134 ? -24.28401 -21.53343 12.40117  1.000 37.04974  ? 134 PHE A HB3  1 
ATOM   2068 H HD1  . PHE A 1 134 ? -25.18853 -22.23119 14.64667  1.000 39.91625  ? 134 PHE A HD1  1 
ATOM   2069 H HD2  . PHE A 1 134 ? -26.37979 -18.86560 12.84767  1.000 40.59934  ? 134 PHE A HD2  1 
ATOM   2070 H HE1  . PHE A 1 134 ? -27.02717 -22.13876 16.04173  1.000 44.40544  ? 134 PHE A HE1  1 
ATOM   2071 H HE2  . PHE A 1 134 ? -28.21496 -18.76806 14.24150  1.000 41.69120  ? 134 PHE A HE2  1 
ATOM   2072 H HZ   . PHE A 1 134 ? -28.54228 -20.40440 15.83967  1.000 44.19212  ? 134 PHE A HZ   1 
ATOM   2073 N N    . THR A 1 135 ? -20.80014 -19.70407 12.73742  1.000 31.62255  ? 135 THR A N    1 
ATOM   2074 C CA   . THR A 1 135 ? -19.49344 -20.00024 12.17039  1.000 31.39441  ? 135 THR A CA   1 
ATOM   2075 C C    . THR A 1 135 ? -18.53883 -20.33549 13.31159  1.000 31.24439  ? 135 THR A C    1 
ATOM   2076 O O    . THR A 1 135 ? -18.83307 -20.09220 14.48630  1.000 28.81175  ? 135 THR A O    1 
ATOM   2077 C CB   . THR A 1 135 ? -18.94788 -18.81883 11.35205  1.000 29.31887  ? 135 THR A CB   1 
ATOM   2078 O OG1  . THR A 1 135 ? -18.73523 -17.69363 12.21397  1.000 31.39410  ? 135 THR A OG1  1 
ATOM   2079 C CG2  . THR A 1 135 ? -19.90954 -18.42562 10.23898  1.000 32.26221  ? 135 THR A CG2  1 
ATOM   2080 H H    . THR A 1 135 ? -20.79384 -19.01542 13.25252  1.000 37.93410  ? 135 THR A H    1 
ATOM   2081 H HA   . THR A 1 135 ? -19.56155 -20.76012 11.57135  1.000 37.66034  ? 135 THR A HA   1 
ATOM   2082 H HB   . THR A 1 135 ? -18.10871 -19.08090 10.94216  1.000 35.16969  ? 135 THR A HB   1 
ATOM   2083 H HG1  . THR A 1 135 ? -18.14838 -17.87701 12.78632  1.000 37.65997  ? 135 THR A HG1  1 
ATOM   2084 H HG21 . THR A 1 135 ? -20.81808 -18.40322 10.57802  1.000 38.70170  ? 135 THR A HG21 1 
ATOM   2085 H HG22 . THR A 1 135 ? -19.67957 -17.54767 9.89661   1.000 38.70170  ? 135 THR A HG22 1 
ATOM   2086 H HG23 . THR A 1 135 ? -19.85958 -19.06895 9.51473   1.000 38.70170  ? 135 THR A HG23 1 
ATOM   2087 N N    . ILE A 1 136 ? -17.38587 -20.90440 12.96288  1.000 28.84058  ? 136 ILE A N    1 
ATOM   2088 C CA   . ILE A 1 136 ? -16.31039 -21.11376 13.92289  1.000 28.59816  ? 136 ILE A CA   1 
ATOM   2089 C C    . ILE A 1 136 ? -15.01739 -20.56551 13.33595  1.000 26.72914  ? 136 ILE A C    1 
ATOM   2090 O O    . ILE A 1 136 ? -14.84921 -20.46613 12.11550  1.000 30.10893  ? 136 ILE A O    1 
ATOM   2091 C CB   . ILE A 1 136 ? -16.14174 -22.60123 14.32850  1.000 31.14385  ? 136 ILE A CB   1 
ATOM   2092 C CG1  . ILE A 1 136 ? -15.61340 -23.43750 13.15482  1.000 30.49535  ? 136 ILE A CG1  1 
ATOM   2093 C CG2  . ILE A 1 136 ? -17.46660 -23.16036 14.86166  1.000 28.00641  ? 136 ILE A CG2  1 
ATOM   2094 C CD1  . ILE A 1 136 ? -15.33241 -24.90615 13.50293  1.000 28.35484  ? 136 ILE A CD1  1 
ATOM   2095 H H    . ILE A 1 136 ? -17.20409 -21.17897 12.16842  1.000 34.59574  ? 136 ILE A H    1 
ATOM   2096 H HA   . ILE A 1 136 ? -16.51824 -20.61650 14.72939  1.000 34.30484  ? 136 ILE A HA   1 
ATOM   2097 H HB   . ILE A 1 136 ? -15.48251 -22.65037 15.03835  1.000 37.35966  ? 136 ILE A HB   1 
ATOM   2098 H HG12 . ILE A 1 136 ? -16.27294 -23.42500 12.44366  1.000 36.58147  ? 136 ILE A HG12 1 
ATOM   2099 H HG13 . ILE A 1 136 ? -14.78266 -23.04503 12.84379  1.000 36.58147  ? 136 ILE A HG13 1 
ATOM   2100 H HG21 . ILE A 1 136 ? -18.13338 -23.11719 14.15849  1.000 33.59474  ? 136 ILE A HG21 1 
ATOM   2101 H HG22 . ILE A 1 136 ? -17.33341 -24.08144 15.13511  1.000 33.59474  ? 136 ILE A HG22 1 
ATOM   2102 H HG23 . ILE A 1 136 ? -17.75144 -22.62785 15.62074  1.000 33.59474  ? 136 ILE A HG23 1 
ATOM   2103 H HD11 . ILE A 1 136 ? -16.13451 -25.30037 13.87994  1.000 34.01285  ? 136 ILE A HD11 1 
ATOM   2104 H HD12 . ILE A 1 136 ? -15.07959 -25.37944 12.69487  1.000 34.01285  ? 136 ILE A HD12 1 
ATOM   2105 H HD13 . ILE A 1 136 ? -14.60976 -24.94492 14.14881  1.000 34.01285  ? 136 ILE A HD13 1 
ATOM   2106 N N    . LYS A 1 137 ? -14.10637 -20.19390 14.22530  1.000 31.08409  ? 137 LYS A N    1 
ATOM   2107 C CA   . LYS A 1 137 ? -12.80189 -19.64936 13.86853  1.000 34.77326  ? 137 LYS A CA   1 
ATOM   2108 C C    . LYS A 1 137 ? -11.77199 -20.72872 14.18794  1.000 34.01140  ? 137 LYS A C    1 
ATOM   2109 O O    . LYS A 1 137 ? -11.16407 -20.74909 15.26039  1.000 35.58047  ? 137 LYS A O    1 
ATOM   2110 C CB   . LYS A 1 137 ? -12.51150 -18.34381 14.62273  1.000 36.45394  ? 137 LYS A CB   1 
ATOM   2111 C CG   . LYS A 1 137 ? -13.64673 -17.33177 14.60339  1.000 36.90037  ? 137 LYS A CG   1 
ATOM   2112 C CD   . LYS A 1 137 ? -13.11482 -15.91823 14.81982  1.000 42.53887  ? 137 LYS A CD   1 
ATOM   2113 C CE   . LYS A 1 137 ? -14.11945 -15.02290 15.52981  1.000 46.96405  ? 137 LYS A CE   1 
ATOM   2114 N NZ   . LYS A 1 137 ? -14.15346 -15.27589 17.00191  1.000 50.90847  ? 137 LYS A NZ   1 
ATOM   2115 H H    . LYS A 1 137 ? -14.22500 -20.24966 15.07525  1.000 37.28796  ? 137 LYS A H    1 
ATOM   2116 H HA   . LYS A 1 137 ? -12.78293 -19.44915 12.91961  1.000 41.71496  ? 137 LYS A HA   1 
ATOM   2117 H HB2  . LYS A 1 137 ? -12.32752 -18.55850 15.55061  1.000 43.73177  ? 137 LYS A HB2  1 
ATOM   2118 H HB3  . LYS A 1 137 ? -11.73676 -17.92127 14.22007  1.000 43.73177  ? 137 LYS A HB3  1 
ATOM   2119 H HG2  . LYS A 1 137 ? -14.09497 -17.36388 13.74377  1.000 44.26749  ? 137 LYS A HG2  1 
ATOM   2120 H HG3  . LYS A 1 137 ? -14.27540 -17.53629 15.31321  1.000 44.26749  ? 137 LYS A HG3  1 
ATOM   2121 H HD2  . LYS A 1 137 ? -12.31241 -15.96030 15.36321  1.000 51.03369  ? 137 LYS A HD2  1 
ATOM   2122 H HD3  . LYS A 1 137 ? -12.91206 -15.51966 13.95905  1.000 51.03369  ? 137 LYS A HD3  1 
ATOM   2123 H HE2  . LYS A 1 137 ? -13.87601 -14.09477 15.38764  1.000 56.34391  ? 137 LYS A HE2  1 
ATOM   2124 H HE3  . LYS A 1 137 ? -15.00546 -15.19190 15.17300  1.000 56.34391  ? 137 LYS A HE3  1 
ATOM   2125 H HZ1  . LYS A 1 137 ? -14.41957 -16.11007 17.16134  1.000 61.07721  ? 137 LYS A HZ1  1 
ATOM   2126 H HZ2  . LYS A 1 137 ? -13.34238 -15.16003 17.34950  1.000 61.07721  ? 137 LYS A HZ2  1 
ATOM   2127 H HZ3  . LYS A 1 137 ? -14.71923 -14.71219 17.39465  1.000 61.07721  ? 137 LYS A HZ3  1 
ATOM   2128 N N    . GLY A 1 138 ? -11.59924 -21.65372 13.24417  1.000 33.38585  ? 138 GLY A N    1 
ATOM   2129 C CA   . GLY A 1 138 ? -10.66906 -22.73822 13.38008  1.000 33.54701  ? 138 GLY A CA   1 
ATOM   2130 C C    . GLY A 1 138 ? -9.44711  -22.56871 12.50363  1.000 33.03291  ? 138 GLY A C    1 
ATOM   2131 O O    . GLY A 1 138 ? -9.12404  -21.46773 12.03780  1.000 32.10744  ? 138 GLY A O    1 
ATOM   2132 H H    . GLY A 1 138 ? -12.02883 -21.66231 12.49920  1.000 40.05007  ? 138 GLY A H    1 
ATOM   2133 H HA2  . GLY A 1 138 ? -10.37668 -22.79557 14.30318  1.000 40.24346  ? 138 GLY A HA2  1 
ATOM   2134 H HA3  . GLY A 1 138 ? -11.10708 -23.56838 13.13539  1.000 40.24346  ? 138 GLY A HA3  1 
ATOM   2135 N N    . SER A 1 139 ? -8.74933  -23.68189 12.28323  1.000 32.12149  ? 139 SER A N    1 
ATOM   2136 C CA   . SER A 1 139 ? -7.57858  -23.73711 11.41010  1.000 29.96758  ? 139 SER A CA   1 
ATOM   2137 C C    . SER A 1 139 ? -7.75137  -24.96162 10.51858  1.000 29.56348  ? 139 SER A C    1 
ATOM   2138 O O    . SER A 1 139 ? -7.55976  -26.09460 10.96787  1.000 28.43018  ? 139 SER A O    1 
ATOM   2139 C CB   . SER A 1 139 ? -6.28407  -23.80697 12.21307  1.000 29.50828  ? 139 SER A CB   1 
ATOM   2140 O OG   . SER A 1 139 ? -5.16019  -23.87667 11.35379  1.000 31.98932  ? 139 SER A OG   1 
ATOM   2141 H H    . SER A 1 139 ? -8.94104  -24.44080 12.63947  1.000 38.53284  ? 139 SER A H    1 
ATOM   2142 H HA   . SER A 1 139 ? -7.53998  -22.94110 10.85712  1.000 35.94815  ? 139 SER A HA   1 
ATOM   2143 H HB2  . SER A 1 139 ? -6.21121  -23.01206 12.76417  1.000 35.39699  ? 139 SER A HB2  1 
ATOM   2144 H HB3  . SER A 1 139 ? -6.30255  -24.59857 12.77337  1.000 35.39699  ? 139 SER A HB3  1 
ATOM   2145 H HG   . SER A 1 139 ? -5.07366  -23.15381 10.93476  1.000 38.37423  ? 139 SER A HG   1 
ATOM   2146 N N    . PHE A 1 140 ? -8.12323  -24.72999 9.26168   1.000 29.24175  ? 140 PHE A N    1 
ATOM   2147 C CA   . PHE A 1 140 ? -8.42363  -25.80451 8.33032   1.000 29.66702  ? 140 PHE A CA   1 
ATOM   2148 C C    . PHE A 1 140 ? -7.80937  -25.50454 6.97249   1.000 30.04583  ? 140 PHE A C    1 
ATOM   2149 O O    . PHE A 1 140 ? -7.88991  -24.37434 6.48153   1.000 29.70228  ? 140 PHE A O    1 
ATOM   2150 C CB   . PHE A 1 140 ? -9.93669  -25.99545 8.16633   1.000 30.27607  ? 140 PHE A CB   1 
ATOM   2151 C CG   . PHE A 1 140 ? -10.63990 -26.42141 9.42317   1.000 28.63665  ? 140 PHE A CG   1 
ATOM   2152 C CD1  . PHE A 1 140 ? -10.44705 -27.68719 9.94891   1.000 29.32872  ? 140 PHE A CD1  1 
ATOM   2153 C CD2  . PHE A 1 140 ? -11.51616 -25.56284 10.06367  1.000 30.36298  ? 140 PHE A CD2  1 
ATOM   2154 C CE1  . PHE A 1 140 ? -11.10571 -28.07962 11.10029  1.000 26.84414  ? 140 PHE A CE1  1 
ATOM   2155 C CE2  . PHE A 1 140 ? -12.17514 -25.94973 11.21255  1.000 28.63984  ? 140 PHE A CE2  1 
ATOM   2156 C CZ   . PHE A 1 140 ? -11.97072 -27.21073 11.72920  1.000 29.64888  ? 140 PHE A CZ   1 
ATOM   2157 H H    . PHE A 1 140 ? -8.20911  -23.94432 8.92264   1.000 35.07714  ? 140 PHE A H    1 
ATOM   2158 H HA   . PHE A 1 140 ? -8.03451  -26.62733 8.66566   1.000 35.58747  ? 140 PHE A HA   1 
ATOM   2159 H HB2  . PHE A 1 140 ? -10.32684 -25.15452 7.88082   1.000 36.31833  ? 140 PHE A HB2  1 
ATOM   2160 H HB3  . PHE A 1 140 ? -10.09276 -26.67834 7.49536   1.000 36.31833  ? 140 PHE A HB3  1 
ATOM   2161 H HD1  . PHE A 1 140 ? -9.86928  -28.27934 9.52413   1.000 35.18151  ? 140 PHE A HD1  1 
ATOM   2162 H HD2  . PHE A 1 140 ? -11.66291 -24.71330 9.71489   1.000 36.42262  ? 140 PHE A HD2  1 
ATOM   2163 H HE1  . PHE A 1 140 ? -10.96473 -28.92981 11.44987  1.000 32.20002  ? 140 PHE A HE1  1 
ATOM   2164 H HE2  . PHE A 1 140 ? -12.75606 -25.36067 11.63734  1.000 34.35486  ? 140 PHE A HE2  1 
ATOM   2165 H HZ   . PHE A 1 140 ? -12.41613 -27.47510 12.50161  1.000 35.56570  ? 140 PHE A HZ   1 
ATOM   2166 N N    . LEU A 1 141 ? -7.20061  -26.52196 6.37547   1.000 29.49646  ? 141 LEU A N    1 
ATOM   2167 C CA   . LEU A 1 141 ? -6.66844  -26.46340 5.02230   1.000 30.08200  ? 141 LEU A CA   1 
ATOM   2168 C C    . LEU A 1 141 ? -7.42902  -27.44398 4.13708   1.000 29.81693  ? 141 LEU A C    1 
ATOM   2169 O O    . LEU A 1 141 ? -8.30094  -28.18971 4.59554   1.000 29.26711  ? 141 LEU A O    1 
ATOM   2170 C CB   . LEU A 1 141 ? -5.17031  -26.77673 5.01379   1.000 30.90498  ? 141 LEU A CB   1 
ATOM   2171 C CG   . LEU A 1 141 ? -4.28138  -25.86327 5.85615   1.000 30.35586  ? 141 LEU A CG   1 
ATOM   2172 C CD1  . LEU A 1 141 ? -2.90128  -26.47470 6.02340   1.000 33.98577  ? 141 LEU A CD1  1 
ATOM   2173 C CD2  . LEU A 1 141 ? -4.17909  -24.47728 5.23112   1.000 30.58772  ? 141 LEU A CD2  1 
ATOM   2174 H H    . LEU A 1 141 ? -7.07990  -27.28642 6.75049   1.000 35.38280  ? 141 LEU A H    1 
ATOM   2175 H HA   . LEU A 1 141 ? -6.79464  -25.56810 4.67099   1.000 36.08545  ? 141 LEU A HA   1 
ATOM   2176 H HB2  . LEU A 1 141 ? -5.04974  -27.67951 5.34748   1.000 37.07303  ? 141 LEU A HB2  1 
ATOM   2177 H HB3  . LEU A 1 141 ? -4.85545  -26.71662 4.09828   1.000 37.07303  ? 141 LEU A HB3  1 
ATOM   2178 H HG   . LEU A 1 141 ? -4.67941  -25.76373 6.73511   1.000 36.41408  ? 141 LEU A HG   1 
ATOM   2179 H HD11 . LEU A 1 141 ? -2.41038  -26.37839 5.19236   1.000 40.76997  ? 141 LEU A HD11 1 
ATOM   2180 H HD12 . LEU A 1 141 ? -2.43570  -26.01274 6.73805   1.000 40.76997  ? 141 LEU A HD12 1 
ATOM   2181 H HD13 . LEU A 1 141 ? -2.99683  -27.41441 6.24413   1.000 40.76997  ? 141 LEU A HD13 1 
ATOM   2182 H HD21 . LEU A 1 141 ? -3.80218  -23.86448 5.88174   1.000 36.69231  ? 141 LEU A HD21 1 
ATOM   2183 H HD22 . LEU A 1 141 ? -3.60559  -24.52454 4.45024   1.000 36.69231  ? 141 LEU A HD22 1 
ATOM   2184 H HD23 . LEU A 1 141 ? -5.06591  -24.18112 4.97277   1.000 36.69231  ? 141 LEU A HD23 1 
ATOM   2185 N N    . ASN A 1 142 ? -7.09102  -27.43779 2.85124   1.000 34.43692  ? 142 ASN A N    1 
ATOM   2186 C CA   . ASN A 1 142 ? -7.66768  -28.41117 1.93618   1.000 33.74558  ? 142 ASN A CA   1 
ATOM   2187 C C    . ASN A 1 142 ? -7.39608  -29.82168 2.44236   1.000 31.57307  ? 142 ASN A C    1 
ATOM   2188 O O    . ASN A 1 142 ? -6.30137  -30.13002 2.92411   1.000 28.96801  ? 142 ASN A O    1 
ATOM   2189 C CB   . ASN A 1 142 ? -7.09828  -28.22381 0.52953   1.000 38.10087  ? 142 ASN A CB   1 
ATOM   2190 C CG   . ASN A 1 142 ? -7.91355  -27.25052 -0.30358  1.000 47.16486  ? 142 ASN A CG   1 
ATOM   2191 O OD1  . ASN A 1 142 ? -7.93402  -26.04992 -0.03538  1.000 48.03027  ? 142 ASN A OD1  1 
ATOM   2192 N ND2  . ASN A 1 142 ? -8.58642  -27.76587 -1.32554  1.000 46.77480  ? 142 ASN A ND2  1 
ATOM   2193 H H    . ASN A 1 142 ? -6.53764  -26.88759 2.48979   1.000 41.31135  ? 142 ASN A H    1 
ATOM   2194 H HA   . ASN A 1 142 ? -8.62767  -28.28340 1.88154   1.000 40.48174  ? 142 ASN A HA   1 
ATOM   2195 H HB2  . ASN A 1 142 ? -6.19437  -27.87839 0.59692   1.000 45.70809  ? 142 ASN A HB2  1 
ATOM   2196 H HB3  . ASN A 1 142 ? -7.09320  -29.07968 0.07307   1.000 45.70809  ? 142 ASN A HB3  1 
ATOM   2197 H HD21 . ASN A 1 142 ? -9.06311  -27.25567 -1.82760  1.000 56.11681  ? 142 ASN A HD21 1 
ATOM   2198 H HD22 . ASN A 1 142 ? -8.54558  -28.60989 -1.48545  1.000 56.11681  ? 142 ASN A HD22 1 
ATOM   2199 N N    . GLY A 1 143 ? -8.40898  -30.67719 2.34342   1.000 28.13059  ? 143 GLY A N    1 
ATOM   2200 C CA   . GLY A 1 143 ? -8.31823  -32.03042 2.84511   1.000 29.15494  ? 143 GLY A CA   1 
ATOM   2201 C C    . GLY A 1 143 ? -8.68456  -32.19913 4.30508   1.000 28.33854  ? 143 GLY A C    1 
ATOM   2202 O O    . GLY A 1 143 ? -8.71662  -33.33869 4.78854   1.000 27.16151  ? 143 GLY A O    1 
ATOM   2203 H H    . GLY A 1 143 ? -9.16712  -30.48886 1.98375   1.000 33.74375  ? 143 GLY A H    1 
ATOM   2204 H HA2  . GLY A 1 143 ? -8.91198  -32.59412 2.32492   1.000 34.97297  ? 143 GLY A HA2  1 
ATOM   2205 H HA3  . GLY A 1 143 ? -7.40679  -32.34237 2.73169   1.000 34.97297  ? 143 GLY A HA3  1 
ATOM   2206 N N    . SER A 1 144 ? -8.96335  -31.10804 5.02137   1.000 27.87106  ? 144 SER A N    1 
ATOM   2207 C CA   . SER A 1 144 ? -9.30772  -31.17747 6.43762   1.000 26.38451  ? 144 SER A CA   1 
ATOM   2208 C C    . SER A 1 144 ? -10.76682 -31.52939 6.68548   1.000 25.29219  ? 144 SER A C    1 
ATOM   2209 O O    . SER A 1 144 ? -11.13702 -31.79819 7.83750   1.000 24.99782  ? 144 SER A O    1 
ATOM   2210 C CB   . SER A 1 144 ? -9.01233  -29.84220 7.11907   1.000 28.03000  ? 144 SER A CB   1 
ATOM   2211 O OG   . SER A 1 144 ? -9.93181  -28.85117 6.69418   1.000 29.12120  ? 144 SER A OG   1 
ATOM   2212 H H    . SER A 1 144 ? -8.95919  -30.30846 4.70473   1.000 33.43232  ? 144 SER A H    1 
ATOM   2213 H HA   . SER A 1 144 ? -8.75496  -31.86339 6.84368   1.000 31.64845  ? 144 SER A HA   1 
ATOM   2214 H HB2  . SER A 1 144 ? -9.08795  -29.95334 8.07971   1.000 33.62304  ? 144 SER A HB2  1 
ATOM   2215 H HB3  . SER A 1 144 ? -8.11352  -29.56044 6.88743   1.000 33.62304  ? 144 SER A HB3  1 
ATOM   2216 H HG   . SER A 1 144 ? -10.69731 -29.02155 6.99515   1.000 34.93249  ? 144 SER A HG   1 
ATOM   2217 N N    . CYS A 1 145 ? -11.60352 -31.51942 5.65421   1.000 24.46520  ? 145 CYS A N    1 
ATOM   2218 C CA   . CYS A 1 145 ? -13.01617 -31.80265 5.85532   1.000 24.34934  ? 145 CYS A CA   1 
ATOM   2219 C C    . CYS A 1 145 ? -13.19621 -33.21456 6.40034   1.000 23.46693  ? 145 CYS A C    1 
ATOM   2220 O O    . CYS A 1 145 ? -12.41064 -34.12435 6.11585   1.000 22.45854  ? 145 CYS A O    1 
ATOM   2221 C CB   . CYS A 1 145 ? -13.78282 -31.61116 4.54780   1.000 25.23761  ? 145 CYS A CB   1 
ATOM   2222 S SG   . CYS A 1 145 ? -14.00069 -29.86358 4.11655   1.000 25.05463  ? 145 CYS A SG   1 
ATOM   2223 H H    . CYS A 1 145 ? -11.38100 -31.35392 4.84015   1.000 29.34528  ? 145 CYS A H    1 
ATOM   2224 H HA   . CYS A 1 145 ? -13.39289 -31.18710 6.50345   1.000 29.20626  ? 145 CYS A HA   1 
ATOM   2225 H HB2  . CYS A 1 145 ? -13.29316 -32.03993 3.82857   1.000 30.27218  ? 145 CYS A HB2  1 
ATOM   2226 H HB3  . CYS A 1 145 ? -14.66200 -32.01150 4.63534   1.000 30.27218  ? 145 CYS A HB3  1 
ATOM   2227 N N    . GLY A 1 146 ? -14.23907 -33.38633 7.21482   1.000 21.44505  ? 146 GLY A N    1 
ATOM   2228 C CA   . GLY A 1 146 ? -14.43911 -34.59835 7.96219   1.000 22.38423  ? 146 GLY A CA   1 
ATOM   2229 C C    . GLY A 1 146 ? -13.82991 -34.58411 9.34549   1.000 21.84921  ? 146 GLY A C    1 
ATOM   2230 O O    . GLY A 1 146 ? -14.22097 -35.39955 10.18727  1.000 22.95369  ? 146 GLY A O    1 
ATOM   2231 H H    . GLY A 1 146 ? -14.84983 -32.79502 7.34493   1.000 25.72110  ? 146 GLY A H    1 
ATOM   2232 H HA2  . GLY A 1 146 ? -15.39189 -34.75337 8.05757   1.000 26.84812  ? 146 GLY A HA2  1 
ATOM   2233 H HA3  . GLY A 1 146 ? -14.04658 -35.33704 7.47111   1.000 26.84812  ? 146 GLY A HA3  1 
ATOM   2234 N N    . SER A 1 147 ? -12.86997 -33.69485 9.59888   1.000 21.23594  ? 147 SER A N    1 
ATOM   2235 C CA   . SER A 1 147 ? -12.44114 -33.43420 10.96353  1.000 21.53241  ? 147 SER A CA   1 
ATOM   2236 C C    . SER A 1 147 ? -13.65652 -33.06089 11.80166  1.000 21.98465  ? 147 SER A C    1 
ATOM   2237 O O    . SER A 1 147 ? -14.60533 -32.44431 11.30823  1.000 24.08456  ? 147 SER A O    1 
ATOM   2238 C CB   . SER A 1 147 ? -11.41002 -32.30678 11.00206  1.000 22.30158  ? 147 SER A CB   1 
ATOM   2239 O OG   . SER A 1 147 ? -10.27030 -32.60658 10.21939  1.000 24.32777  ? 147 SER A OG   1 
ATOM   2240 H H    . SER A 1 147 ? -12.45686 -33.23498 9.00100   1.000 25.47017  ? 147 SER A H    1 
ATOM   2241 H HA   . SER A 1 147 ? -12.01988 -34.22408 11.33706  1.000 25.82594  ? 147 SER A HA   1 
ATOM   2242 H HB2  . SER A 1 147 ? -11.82006 -31.49781 10.65805  1.000 26.74895  ? 147 SER A HB2  1 
ATOM   2243 H HB3  . SER A 1 147 ? -11.13013 -32.17197 11.92096  1.000 26.74895  ? 147 SER A HB3  1 
ATOM   2244 H HG   . SER A 1 147 ? -10.41506 -32.41266 9.41500   1.000 29.18037  ? 147 SER A HG   1 
ATOM   2245 N N    . VAL A 1 148 ? -13.63207 -33.43371 13.07986  1.000 21.73139  ? 148 VAL A N    1 
ATOM   2246 C CA   . VAL A 1 148 ? -14.82616 -33.34965 13.90800  1.000 20.47049  ? 148 VAL A CA   1 
ATOM   2247 C C    . VAL A 1 148 ? -14.54474 -32.53016 15.15486  1.000 23.63214  ? 148 VAL A C    1 
ATOM   2248 O O    . VAL A 1 148 ? -13.40497 -32.40530 15.60702  1.000 22.92042  ? 148 VAL A O    1 
ATOM   2249 C CB   . VAL A 1 148 ? -15.35488 -34.74591 14.29716  1.000 21.18840  ? 148 VAL A CB   1 
ATOM   2250 C CG1  . VAL A 1 148 ? -15.74039 -35.51955 13.04915  1.000 22.72458  ? 148 VAL A CG1  1 
ATOM   2251 C CG2  . VAL A 1 148 ? -14.31507 -35.50280 15.11022  1.000 22.13750  ? 148 VAL A CG2  1 
ATOM   2252 H H    . VAL A 1 148 ? -12.93694 -33.73697 13.48536  1.000 26.06471  ? 148 VAL A H    1 
ATOM   2253 H HA   . VAL A 1 148 ? -15.51112 -32.87978 13.40704  1.000 24.55164  ? 148 VAL A HA   1 
ATOM   2254 H HB   . VAL A 1 148 ? -16.14568 -34.64797 14.85027  1.000 25.41313  ? 148 VAL A HB   1 
ATOM   2255 H HG11 . VAL A 1 148 ? -16.23742 -36.31093 13.30912  1.000 27.25655  ? 148 VAL A HG11 1 
ATOM   2256 H HG12 . VAL A 1 148 ? -16.29031 -34.95424 12.48444  1.000 27.25655  ? 148 VAL A HG12 1 
ATOM   2257 H HG13 . VAL A 1 148 ? -14.93402 -35.77629 12.57507  1.000 27.25655  ? 148 VAL A HG13 1 
ATOM   2258 H HG21 . VAL A 1 148 ? -14.07321 -34.97250 15.88558  1.000 26.55205  ? 148 VAL A HG21 1 
ATOM   2259 H HG22 . VAL A 1 148 ? -14.69171 -36.35055 15.39371  1.000 26.55205  ? 148 VAL A HG22 1 
ATOM   2260 H HG23 . VAL A 1 148 ? -13.53285 -35.65664 14.55763  1.000 26.55205  ? 148 VAL A HG23 1 
ATOM   2261 N N    . GLY A 1 149 ? -15.61877 -31.96361 15.70415  1.000 22.18799  ? 149 GLY A N    1 
ATOM   2262 C CA   . GLY A 1 149 ? -15.58060 -31.26976 16.97622  1.000 23.78236  ? 149 GLY A CA   1 
ATOM   2263 C C    . GLY A 1 149 ? -16.31931 -32.08902 18.01847  1.000 23.48872  ? 149 GLY A C    1 
ATOM   2264 O O    . GLY A 1 149 ? -17.29794 -32.77030 17.70732  1.000 23.11518  ? 149 GLY A O    1 
ATOM   2265 H H    . GLY A 1 149 ? -16.39956 -31.97172 15.34373  1.000 26.61264  ? 149 GLY A H    1 
ATOM   2266 H HA2  . GLY A 1 149 ? -14.66158 -31.14670 17.26112  1.000 28.52588  ? 149 GLY A HA2  1 
ATOM   2267 H HA3  . GLY A 1 149 ? -16.00498 -30.40132 16.89487  1.000 28.52588  ? 149 GLY A HA3  1 
ATOM   2268 N N    . PHE A 1 150 ? -15.85073 -32.02541 19.26187  1.000 24.79206  ? 150 PHE A N    1 
ATOM   2269 C CA   . PHE A 1 150 ? -16.37864 -32.91658 20.28325  1.000 23.08902  ? 150 PHE A CA   1 
ATOM   2270 C C    . PHE A 1 150 ? -16.17604 -32.32181 21.66817  1.000 28.17278  ? 150 PHE A C    1 
ATOM   2271 O O    . PHE A 1 150 ? -15.28829 -31.49328 21.89232  1.000 28.47788  ? 150 PHE A O    1 
ATOM   2272 C CB   . PHE A 1 150 ? -15.70409 -34.29399 20.20488  1.000 24.91303  ? 150 PHE A CB   1 
ATOM   2273 C CG   . PHE A 1 150 ? -14.21649 -34.24870 20.43781  1.000 23.78694  ? 150 PHE A CG   1 
ATOM   2274 C CD1  . PHE A 1 150 ? -13.36175 -33.81188 19.44211  1.000 26.44689  ? 150 PHE A CD1  1 
ATOM   2275 C CD2  . PHE A 1 150 ? -13.67855 -34.62799 21.65213  1.000 24.87623  ? 150 PHE A CD2  1 
ATOM   2276 C CE1  . PHE A 1 150 ? -11.99649 -33.75895 19.65024  1.000 25.94795  ? 150 PHE A CE1  1 
ATOM   2277 C CE2  . PHE A 1 150 ? -12.31281 -34.58132 21.86711  1.000 27.46518  ? 150 PHE A CE2  1 
ATOM   2278 C CZ   . PHE A 1 150 ? -11.47128 -34.14743 20.86405  1.000 26.35352  ? 150 PHE A CZ   1 
ATOM   2279 H H    . PHE A 1 150 ? -15.23901 -31.48440 19.53150  1.000 29.73752  ? 150 PHE A H    1 
ATOM   2280 H HA   . PHE A 1 150 ? -17.33443 -33.00677 20.14460  1.000 27.69387  ? 150 PHE A HA   1 
ATOM   2281 H HB2  . PHE A 1 150 ? -16.09308 -34.87170 20.88004  1.000 29.88268  ? 150 PHE A HB2  1 
ATOM   2282 H HB3  . PHE A 1 150 ? -15.85539 -34.66666 19.32219  1.000 29.88268  ? 150 PHE A HB3  1 
ATOM   2283 H HD1  . PHE A 1 150 ? -13.71069 -33.55004 18.62078  1.000 31.72332  ? 150 PHE A HD1  1 
ATOM   2284 H HD2  . PHE A 1 150 ? -14.24123 -34.91822 22.33334  1.000 29.83852  ? 150 PHE A HD2  1 
ATOM   2285 H HE1  . PHE A 1 150 ? -11.43315 -33.46176 18.97257  1.000 31.12458  ? 150 PHE A HE1  1 
ATOM   2286 H HE2  . PHE A 1 150 ? -11.96206 -34.84248 22.68789  1.000 32.94526  ? 150 PHE A HE2  1 
ATOM   2287 H HZ   . PHE A 1 150 ? -10.55270 -34.11708 21.00619  1.000 31.61127  ? 150 PHE A HZ   1 
ATOM   2288 N N    . ASN A 1 151 ? -17.02747 -32.76241 22.59002  1.000 26.60819  ? 151 ASN A N    1 
ATOM   2289 C CA   . ASN A 1 151 ? -16.83120 -32.60689 24.02284  1.000 30.69691  ? 151 ASN A CA   1 
ATOM   2290 C C    . ASN A 1 151 ? -16.73622 -33.99200 24.65241  1.000 32.52691  ? 151 ASN A C    1 
ATOM   2291 O O    . ASN A 1 151 ? -17.15306 -34.99105 24.05969  1.000 31.68521  ? 151 ASN A O    1 
ATOM   2292 C CB   . ASN A 1 151 ? -17.97804 -31.82080 24.67125  1.000 32.08648  ? 151 ASN A CB   1 
ATOM   2293 C CG   . ASN A 1 151 ? -17.89826 -30.33427 24.39468  1.000 31.04415  ? 151 ASN A CG   1 
ATOM   2294 O OD1  . ASN A 1 151 ? -17.11006 -29.62087 25.01292  1.000 32.30565  ? 151 ASN A OD1  1 
ATOM   2295 N ND2  . ASN A 1 151 ? -18.72686 -29.85624 23.47487  1.000 29.03149  ? 151 ASN A ND2  1 
ATOM   2296 H H    . ASN A 1 151 ? -17.75850 -33.17294 22.39857  1.000 31.91687  ? 151 ASN A H    1 
ATOM   2297 H HA   . ASN A 1 151 ? -16.01023 -32.11874 24.19205  1.000 36.82333  ? 151 ASN A HA   1 
ATOM   2298 H HB2  . ASN A 1 151 ? -18.82206 -32.14626 24.32110  1.000 38.49082  ? 151 ASN A HB2  1 
ATOM   2299 H HB3  . ASN A 1 151 ? -17.94584 -31.94936 25.63216  1.000 38.49082  ? 151 ASN A HB3  1 
ATOM   2300 H HD21 . ASN A 1 151 ? -18.71886 -29.01797 23.28293  1.000 34.82483  ? 151 ASN A HD21 1 
ATOM   2301 H HD22 . ASN A 1 151 ? -19.27182 -30.38472 23.07074  1.000 34.82483  ? 151 ASN A HD22 1 
ATOM   2302 N N    . ILE A 1 152 ? -16.18207 -34.05194 25.86138  1.000 32.60363  ? 152 ILE A N    1 
ATOM   2303 C CA   . ILE A 1 152 ? -16.09798 -35.29721 26.61618  1.000 35.88842  ? 152 ILE A CA   1 
ATOM   2304 C C    . ILE A 1 152 ? -16.60466 -35.03653 28.02765  1.000 39.74330  ? 152 ILE A C    1 
ATOM   2305 O O    . ILE A 1 152 ? -16.05405 -34.18938 28.74108  1.000 38.71464  ? 152 ILE A O    1 
ATOM   2306 C CB   . ILE A 1 152 ? -14.66942 -35.86404 26.66017  1.000 37.84461  ? 152 ILE A CB   1 
ATOM   2307 C CG1  . ILE A 1 152 ? -14.07075 -35.93026 25.25436  1.000 32.24228  ? 152 ILE A CG1  1 
ATOM   2308 C CG2  . ILE A 1 152 ? -14.67501 -37.25721 27.28839  1.000 39.24954  ? 152 ILE A CG2  1 
ATOM   2309 C CD1  . ILE A 1 152 ? -12.65235 -36.46487 25.21975  1.000 34.83590  ? 152 ILE A CD1  1 
ATOM   2310 H H    . ILE A 1 152 ? -15.84386 -33.37454 26.26924  1.000 39.11140  ? 152 ILE A H    1 
ATOM   2311 H HA   . ILE A 1 152 ? -16.67572 -35.95387 26.19677  1.000 43.05315  ? 152 ILE A HA   1 
ATOM   2312 H HB   . ILE A 1 152 ? -14.12545 -35.27050 27.20119  1.000 45.40058  ? 152 ILE A HB   1 
ATOM   2313 H HG12 . ILE A 1 152 ? -14.62056 -36.51370 24.70828  1.000 38.67779  ? 152 ILE A HG12 1 
ATOM   2314 H HG13 . ILE A 1 152 ? -14.05965 -35.03649 24.87758  1.000 38.67779  ? 152 ILE A HG13 1 
ATOM   2315 H HG21 . ILE A 1 152 ? -15.14155 -37.86841 26.69707  1.000 47.08650  ? 152 ILE A HG21 1 
ATOM   2316 H HG22 . ILE A 1 152 ? -13.75905 -37.55139 27.41240  1.000 47.08650  ? 152 ILE A HG22 1 
ATOM   2317 H HG23 . ILE A 1 152 ? -15.12789 -37.21547 28.14517  1.000 47.08650  ? 152 ILE A HG23 1 
ATOM   2318 H HD11 . ILE A 1 152 ? -12.66750 -37.41371 25.42067  1.000 41.79013  ? 152 ILE A HD11 1 
ATOM   2319 H HD12 . ILE A 1 152 ? -12.28173 -36.31995 24.33514  1.000 41.79013  ? 152 ILE A HD12 1 
ATOM   2320 H HD13 . ILE A 1 152 ? -12.12152 -35.99500 25.88183  1.000 41.79013  ? 152 ILE A HD13 1 
ATOM   2321 N N    . ASP A 1 153 ? -17.64744 -35.76012 28.42382  1.000 41.61432  ? 153 ASP A N    1 
ATOM   2322 C CA   . ASP A 1 153 ? -18.15584 -35.76346 29.79463  1.000 47.21582  ? 153 ASP A CA   1 
ATOM   2323 C C    . ASP A 1 153 ? -17.73719 -37.10046 30.40571  1.000 49.56168  ? 153 ASP A C    1 
ATOM   2324 O O    . ASP A 1 153 ? -18.43410 -38.10900 30.27511  1.000 49.62200  ? 153 ASP A O    1 
ATOM   2325 C CB   . ASP A 1 153 ? -19.66753 -35.56747 29.83136  1.000 45.10996  ? 153 ASP A CB   1 
ATOM   2326 H H    . ASP A 1 153 ? -18.09295 -36.27529 27.89874  1.000 49.92423  ? 153 ASP A H    1 
ATOM   2327 H HA   . ASP A 1 153 ? -17.75617 -35.03793 30.29939  1.000 56.64604  ? 153 ASP A HA   1 
ATOM   2328 N N    . TYR A 1 154 ? -16.58059 -37.09563 31.06660  1.000 49.37483  ? 154 TYR A N    1 
ATOM   2329 C CA   . TYR A 1 154 ? -15.97404 -38.29506 31.63245  1.000 53.60548  ? 154 TYR A CA   1 
ATOM   2330 C C    . TYR A 1 154 ? -15.62089 -39.30876 30.54730  1.000 52.30102  ? 154 TYR A C    1 
ATOM   2331 O O    . TYR A 1 154 ? -14.58866 -39.16927 29.88364  1.000 53.40163  ? 154 TYR A O    1 
ATOM   2332 C CB   . TYR A 1 154 ? -16.88913 -38.93485 32.68306  1.000 60.48448  ? 154 TYR A CB   1 
ATOM   2333 C CG   . TYR A 1 154 ? -16.22720 -40.09664 33.39697  1.000 61.10342  ? 154 TYR A CG   1 
ATOM   2334 C CD1  . TYR A 1 154 ? -14.98117 -39.94464 33.99003  1.000 60.11186  ? 154 TYR A CD1  1 
ATOM   2335 C CD2  . TYR A 1 154 ? -16.83734 -41.34231 33.46949  1.000 67.55560  ? 154 TYR A CD2  1 
ATOM   2336 C CE1  . TYR A 1 154 ? -14.36062 -40.99391 34.63573  1.000 64.51667  ? 154 TYR A CE1  1 
ATOM   2337 C CE2  . TYR A 1 154 ? -16.22196 -42.40217 34.11910  1.000 72.63468  ? 154 TYR A CE2  1 
ATOM   2338 C CZ   . TYR A 1 154 ? -14.98302 -42.21889 34.70007  1.000 72.56050  ? 154 TYR A CZ   1 
ATOM   2339 O OH   . TYR A 1 154 ? -14.35766 -43.25927 35.34827  1.000 84.96837  ? 154 TYR A OH   1 
ATOM   2340 H H    . TYR A 1 154 ? -16.11355 -36.38680 31.20452  1.000 59.23685  ? 154 TYR A H    1 
ATOM   2341 H HA   . TYR A 1 154 ? -15.15067 -38.03495 32.07439  1.000 64.31362  ? 154 TYR A HA   1 
ATOM   2342 H HB2  . TYR A 1 154 ? -17.12457 -38.26770 33.34667  1.000 72.56842  ? 154 TYR A HB2  1 
ATOM   2343 H HB3  . TYR A 1 154 ? -17.68976 -39.26567 32.24666  1.000 72.56842  ? 154 TYR A HB3  1 
ATOM   2344 H HD1  . TYR A 1 154 ? -14.55607 -39.11839 33.95119  1.000 72.12128  ? 154 TYR A HD1  1 
ATOM   2345 H HD2  . TYR A 1 154 ? -17.67093 -41.46763 33.07664  1.000 81.05377  ? 154 TYR A HD2  1 
ATOM   2346 H HE1  . TYR A 1 154 ? -13.52502 -40.87359 35.02587  1.000 77.40705  ? 154 TYR A HE1  1 
ATOM   2347 H HE2  . TYR A 1 154 ? -16.64132 -43.23109 34.16302  1.000 87.14866  ? 154 TYR A HE2  1 
ATOM   2348 H HH   . TYR A 1 154 ? -13.60975 -43.00937 35.63772  1.000 101.94909 ? 154 TYR A HH   1 
ATOM   2349 N N    . ASP A 1 155 ? -16.45856 -40.33092 30.35953  1.000 54.04435  ? 155 ASP A N    1 
ATOM   2350 C CA   . ASP A 1 155 ? -16.13686 -41.44587 29.47697  1.000 53.25207  ? 155 ASP A CA   1 
ATOM   2351 C C    . ASP A 1 155 ? -16.79808 -41.35387 28.10792  1.000 45.47635  ? 155 ASP A C    1 
ATOM   2352 O O    . ASP A 1 155 ? -16.47306 -42.15940 27.22936  1.000 44.38005  ? 155 ASP A O    1 
ATOM   2353 C CB   . ASP A 1 155 ? -16.54379 -42.77424 30.13465  1.000 52.93824  ? 155 ASP A CB   1 
ATOM   2354 C CG   . ASP A 1 155 ? -18.01257 -42.81116 30.51960  1.000 55.39563  ? 155 ASP A CG   1 
ATOM   2355 O OD1  . ASP A 1 155 ? -18.69886 -41.77858 30.36818  1.000 59.44481  ? 155 ASP A OD1  1 
ATOM   2356 O OD2  . ASP A 1 155 ? -18.48158 -43.87419 30.97616  1.000 58.63039  ? 155 ASP A OD2  1 
ATOM   2357 H H    . ASP A 1 155 ? -17.22766 -40.39916 30.73823  1.000 64.84026  ? 155 ASP A H    1 
ATOM   2358 H HA   . ASP A 1 155 ? -15.17673 -41.45269 29.33914  1.000 63.88953  ? 155 ASP A HA   1 
ATOM   2359 H HB2  . ASP A 1 155 ? -16.37823 -43.49937 29.51201  1.000 63.51293  ? 155 ASP A HB2  1 
ATOM   2360 H HB3  . ASP A 1 155 ? -16.01890 -42.90232 30.94024  1.000 63.51293  ? 155 ASP A HB3  1 
ATOM   2361 N N    . CYS A 1 156 ? -17.69885 -40.39916 27.89968  1.000 42.40673  ? 156 CYS A N    1 
ATOM   2362 C CA   . CYS A 1 156 ? -18.55061 -40.36270 26.71762  1.000 40.75628  ? 156 CYS A CA   1 
ATOM   2363 C C    . CYS A 1 156 ? -18.15393 -39.18883 25.83064  1.000 34.87305  ? 156 CYS A C    1 
ATOM   2364 O O    . CYS A 1 156 ? -18.12993 -38.03997 26.28496  1.000 36.23256  ? 156 CYS A O    1 
ATOM   2365 C CB   . CYS A 1 156 ? -20.02069 -40.26347 27.12789  1.000 38.31784  ? 156 CYS A CB   1 
ATOM   2366 S SG   . CYS A 1 156 ? -21.19388 -40.29941 25.75505  1.000 37.97238  ? 156 CYS A SG   1 
ATOM   2367 H H    . CYS A 1 156 ? -17.83749 -39.74668 28.44250  1.000 50.87512  ? 156 CYS A H    1 
ATOM   2368 H HA   . CYS A 1 156 ? -18.42003 -41.17296 26.20059  1.000 48.89458  ? 156 CYS A HA   1 
ATOM   2369 H HB2  . CYS A 1 156 ? -20.22901 -41.01129 27.70949  1.000 45.96845  ? 156 CYS A HB2  1 
ATOM   2370 H HB3  . CYS A 1 156 ? -20.15204 -39.42763 27.60225  1.000 45.96845  ? 156 CYS A HB3  1 
ATOM   2371 H HG   . CYS A 1 156 ? -21.05231 -39.30790 25.09410  1.000 45.55390  ? 156 CYS A HG   1 
ATOM   2372 N N    . VAL A 1 157 ? -17.85099 -39.48063 24.56831  1.000 30.76267  ? 157 VAL A N    1 
ATOM   2373 C CA   . VAL A 1 157 ? -17.54827 -38.45104 23.58087  1.000 29.24491  ? 157 VAL A CA   1 
ATOM   2374 C C    . VAL A 1 157 ? -18.84953 -37.99605 22.93700  1.000 28.87339  ? 157 VAL A C    1 
ATOM   2375 O O    . VAL A 1 157 ? -19.61445 -38.81503 22.41483  1.000 28.89527  ? 157 VAL A O    1 
ATOM   2376 C CB   . VAL A 1 157 ? -16.56864 -38.97155 22.51782  1.000 27.06405  ? 157 VAL A CB   1 
ATOM   2377 C CG1  . VAL A 1 157 ? -16.21758 -37.85877 21.53720  1.000 25.79262  ? 157 VAL A CG1  1 
ATOM   2378 C CG2  . VAL A 1 157 ? -15.31587 -39.54147 23.16908  1.000 28.56648  ? 157 VAL A CG2  1 
ATOM   2379 H H    . VAL A 1 157 ? -17.81398 -40.28088 24.25553  1.000 36.90225  ? 157 VAL A H    1 
ATOM   2380 H HA   . VAL A 1 157 ? -17.13976 -37.69350 24.02825  1.000 35.08094  ? 157 VAL A HA   1 
ATOM   2381 H HB   . VAL A 1 157 ? -16.99234 -39.68969 22.02219  1.000 32.46391  ? 157 VAL A HB   1 
ATOM   2382 H HG11 . VAL A 1 157 ? -15.45489 -38.13538 21.00551  1.000 30.93819  ? 157 VAL A HG11 1 
ATOM   2383 H HG12 . VAL A 1 157 ? -16.98010 -37.69353 20.96088  1.000 30.93819  ? 157 VAL A HG12 1 
ATOM   2384 H HG13 . VAL A 1 157 ? -15.99952 -37.05573 22.03568  1.000 30.93819  ? 157 VAL A HG13 1 
ATOM   2385 H HG21 . VAL A 1 157 ? -14.66907 -39.75321 22.47791  1.000 34.26682  ? 157 VAL A HG21 1 
ATOM   2386 H HG22 . VAL A 1 157 ? -14.94705 -38.88084 23.77607  1.000 34.26682  ? 157 VAL A HG22 1 
ATOM   2387 H HG23 . VAL A 1 157 ? -15.55200 -40.34498 23.65848  1.000 34.26682  ? 157 VAL A HG23 1 
ATOM   2388 N N    . SER A 1 158 ? -19.10250 -36.69427 22.97489  1.000 28.49807  ? 158 SER A N    1 
ATOM   2389 C CA   . SER A 1 158 ? -20.27446 -36.09027 22.34453  1.000 30.74328  ? 158 SER A CA   1 
ATOM   2390 C C    . SER A 1 158 ? -19.79919 -35.35398 21.09986  1.000 26.19469  ? 158 SER A C    1 
ATOM   2391 O O    . SER A 1 158 ? -19.23649 -34.25942 21.19157  1.000 26.19825  ? 158 SER A O    1 
ATOM   2392 C CB   . SER A 1 158 ? -20.99714 -35.14380 23.29950  1.000 32.01329  ? 158 SER A CB   1 
ATOM   2393 O OG   . SER A 1 158 ? -21.82036 -35.85818 24.20177  1.000 39.14562  ? 158 SER A OG   1 
ATOM   2394 H H    . SER A 1 158 ? -18.59650 -36.12251 23.37068  1.000 34.18473  ? 158 SER A H    1 
ATOM   2395 H HA   . SER A 1 158 ? -20.89269 -36.79159 22.08598  1.000 36.87899  ? 158 SER A HA   1 
ATOM   2396 H HB2  . SER A 1 158 ? -20.33772 -34.64292 23.80466  1.000 38.40299  ? 158 SER A HB2  1 
ATOM   2397 H HB3  . SER A 1 158 ? -21.54989 -34.53712 22.78247  1.000 38.40299  ? 158 SER A HB3  1 
ATOM   2398 H HG   . SER A 1 158 ? -22.44825 -36.22961 23.78535  1.000 46.96179  ? 158 SER A HG   1 
ATOM   2399 N N    . PHE A 1 159 ? -20.02103 -35.96208 19.93894  1.000 27.30179  ? 159 PHE A N    1 
ATOM   2400 C CA   . PHE A 1 159 ? -19.65140 -35.34020 18.67664  1.000 23.61280  ? 159 PHE A CA   1 
ATOM   2401 C C    . PHE A 1 159 ? -20.69699 -34.30669 18.28447  1.000 25.05326  ? 159 PHE A C    1 
ATOM   2402 O O    . PHE A 1 159 ? -21.89841 -34.59334 18.29651  1.000 27.53266  ? 159 PHE A O    1 
ATOM   2403 C CB   . PHE A 1 159 ? -19.51981 -36.39903 17.58216  1.000 24.58883  ? 159 PHE A CB   1 
ATOM   2404 C CG   . PHE A 1 159 ? -18.44603 -37.41065 17.84313  1.000 22.42575  ? 159 PHE A CG   1 
ATOM   2405 C CD1  . PHE A 1 159 ? -17.12000 -37.10951 17.59870  1.000 24.06057  ? 159 PHE A CD1  1 
ATOM   2406 C CD2  . PHE A 1 159 ? -18.76378 -38.67003 18.32183  1.000 24.11015  ? 159 PHE A CD2  1 
ATOM   2407 C CE1  . PHE A 1 159 ? -16.13010 -38.04380 17.83128  1.000 21.85710  ? 159 PHE A CE1  1 
ATOM   2408 C CE2  . PHE A 1 159 ? -17.78091 -39.60599 18.56263  1.000 23.53935  ? 159 PHE A CE2  1 
ATOM   2409 C CZ   . PHE A 1 159 ? -16.45910 -39.29196 18.31755  1.000 24.67706  ? 159 PHE A CZ   1 
ATOM   2410 H H    . PHE A 1 159 ? -20.38513 -36.73689 19.85707  1.000 32.74920  ? 159 PHE A H    1 
ATOM   2411 H HA   . PHE A 1 159 ? -18.79581 -34.89338 18.77262  1.000 28.32241  ? 159 PHE A HA   1 
ATOM   2412 H HB2  . PHE A 1 159 ? -20.36178 -36.87465 17.50613  1.000 29.49364  ? 159 PHE A HB2  1 
ATOM   2413 H HB3  . PHE A 1 159 ? -19.31181 -35.95670 16.74431  1.000 29.49364  ? 159 PHE A HB3  1 
ATOM   2414 H HD1  . PHE A 1 159 ? -16.89160 -36.26849 17.27401  1.000 28.85973  ? 159 PHE A HD1  1 
ATOM   2415 H HD2  . PHE A 1 159 ? -19.65337 -38.88784 18.48334  1.000 28.91923  ? 159 PHE A HD2  1 
ATOM   2416 H HE1  . PHE A 1 159 ? -15.24105 -37.83133 17.65997  1.000 26.21557  ? 159 PHE A HE1  1 
ATOM   2417 H HE2  . PHE A 1 159 ? -18.00760 -40.44671 18.88930  1.000 28.23427  ? 159 PHE A HE2  1 
ATOM   2418 H HZ   . PHE A 1 159 ? -15.79261 -39.91995 18.47977  1.000 29.59952  ? 159 PHE A HZ   1 
ATOM   2419 N N    . CYS A 1 160 ? -20.24134 -33.10752 17.91821  1.000 23.86931  ? 160 CYS A N    1 
ATOM   2420 C CA   . CYS A 1 160 ? -21.15037 -32.01616 17.60645  1.000 27.49847  ? 160 CYS A CA   1 
ATOM   2421 C C    . CYS A 1 160 ? -20.84559 -31.28973 16.30559  1.000 25.85249  ? 160 CYS A C    1 
ATOM   2422 O O    . CYS A 1 160 ? -21.65736 -30.45819 15.88778  1.000 23.79576  ? 160 CYS A O    1 
ATOM   2423 C CB   . CYS A 1 160 ? -21.15663 -30.98461 18.74719  1.000 28.23716  ? 160 CYS A CB   1 
ATOM   2424 S SG   . CYS A 1 160 ? -19.55738 -30.20469 19.06479  1.000 30.13263  ? 160 CYS A SG   1 
ATOM   2425 H H    . CYS A 1 160 ? -19.40863 -32.90574 17.84426  1.000 28.63022  ? 160 CYS A H    1 
ATOM   2426 H HA   . CYS A 1 160 ? -22.04328 -32.38658 17.52635  1.000 32.98520  ? 160 CYS A HA   1 
ATOM   2427 H HB2  . CYS A 1 160 ? -21.78601 -30.28122 18.52356  1.000 33.87164  ? 160 CYS A HB2  1 
ATOM   2428 H HB3  . CYS A 1 160 ? -21.43263 -31.42944 19.56381  1.000 33.87164  ? 160 CYS A HB3  1 
ATOM   2429 H HG   . CYS A 1 160 ? -18.74554 -31.05783 19.29517  1.000 36.14620  ? 160 CYS A HG   1 
ATOM   2430 N N    . TYR A 1 161 ? -19.72621 -31.57491 15.64544  1.000 24.00165  ? 161 TYR A N    1 
ATOM   2431 C CA   . TYR A 1 161 ? -19.33870 -30.80795 14.47471  1.000 23.44840  ? 161 TYR A CA   1 
ATOM   2432 C C    . TYR A 1 161 ? -18.53530 -31.68273 13.52478  1.000 21.29389  ? 161 TYR A C    1 
ATOM   2433 O O    . TYR A 1 161 ? -17.73830 -32.51482 13.95799  1.000 22.48252  ? 161 TYR A O    1 
ATOM   2434 C CB   . TYR A 1 161 ? -18.51752 -29.57698 14.87992  1.000 24.30740  ? 161 TYR A CB   1 
ATOM   2435 C CG   . TYR A 1 161 ? -18.04389 -28.72872 13.72376  1.000 25.31788  ? 161 TYR A CG   1 
ATOM   2436 C CD1  . TYR A 1 161 ? -18.84228 -27.72174 13.20284  1.000 25.03914  ? 161 TYR A CD1  1 
ATOM   2437 C CD2  . TYR A 1 161 ? -16.79463 -28.92811 13.16000  1.000 24.15810  ? 161 TYR A CD2  1 
ATOM   2438 C CE1  . TYR A 1 161 ? -18.41146 -26.94304 12.15324  1.000 26.78639  ? 161 TYR A CE1  1 
ATOM   2439 C CE2  . TYR A 1 161 ? -16.35297 -28.14997 12.11148  1.000 26.01083  ? 161 TYR A CE2  1 
ATOM   2440 C CZ   . TYR A 1 161 ? -17.16523 -27.15926 11.61101  1.000 25.62389  ? 161 TYR A CZ   1 
ATOM   2441 O OH   . TYR A 1 161 ? -16.73311 -26.38258 10.56241  1.000 27.30400  ? 161 TYR A OH   1 
ATOM   2442 H H    . TYR A 1 161 ? -19.18035 -32.20469 15.85760  1.000 28.78902  ? 161 TYR A H    1 
ATOM   2443 H HA   . TYR A 1 161 ? -20.13433 -30.51814 14.00156  1.000 28.12512  ? 161 TYR A HA   1 
ATOM   2444 H HB2  . TYR A 1 161 ? -19.06506 -29.01481 15.45007  1.000 29.15592  ? 161 TYR A HB2  1 
ATOM   2445 H HB3  . TYR A 1 161 ? -17.73212 -29.87582 15.36442  1.000 29.15592  ? 161 TYR A HB3  1 
ATOM   2446 H HD1  . TYR A 1 161 ? -19.68351 -27.57000 13.56918  1.000 30.03402  ? 161 TYR A HD1  1 
ATOM   2447 H HD2  . TYR A 1 161 ? -16.24411 -29.59876 13.49475  1.000 28.97677  ? 161 TYR A HD2  1 
ATOM   2448 H HE1  . TYR A 1 161 ? -18.95982 -26.27391 11.81198  1.000 32.13072  ? 161 TYR A HE1  1 
ATOM   2449 H HE2  . TYR A 1 161 ? -15.51064 -28.29400 11.74457  1.000 31.20004  ? 161 TYR A HE2  1 
ATOM   2450 H HH   . TYR A 1 161 ? -17.32571 -25.82458 10.35489  1.000 32.75184  ? 161 TYR A HH   1 
ATOM   2451 N N    . MET A 1 162 ? -18.77174 -31.49196 12.23316  1.000 23.71025  ? 162 MET A N    1 
ATOM   2452 C CA   . MET A 1 162 ? -17.94063 -32.04806 11.17288  1.000 22.75142  ? 162 MET A CA   1 
ATOM   2453 C C    . MET A 1 162 ? -17.66237 -30.92393 10.19013  1.000 21.79921  ? 162 MET A C    1 
ATOM   2454 O O    . MET A 1 162 ? -18.59044 -30.22329 9.77678   1.000 24.15068  ? 162 MET A O    1 
ATOM   2455 C CB   . MET A 1 162 ? -18.62604 -33.22149 10.47273  1.000 22.49387  ? 162 MET A CB   1 
ATOM   2456 C CG   . MET A 1 162 ? -17.82722 -33.79199 9.30631   1.000 22.75080  ? 162 MET A CG   1 
ATOM   2457 S SD   . MET A 1 162 ? -18.37582 -35.42264 8.78003   1.000 22.72967  ? 162 MET A SD   1 
ATOM   2458 C CE   . MET A 1 162 ? -17.46544 -36.48471 9.90099   1.000 25.35020  ? 162 MET A CE   1 
ATOM   2459 H H    . MET A 1 162 ? -19.43121 -31.02741 11.93502  1.000 28.43934  ? 162 MET A H    1 
ATOM   2460 H HA   . MET A 1 162 ? -17.10962 -32.38957 11.53850  1.000 27.28875  ? 162 MET A HA   1 
ATOM   2461 H HB2  . MET A 1 162 ? -18.75949 -33.93420 11.11703  1.000 26.97969  ? 162 MET A HB2  1 
ATOM   2462 H HB3  . MET A 1 162 ? -19.48157 -32.92195 10.12741  1.000 26.97969  ? 162 MET A HB3  1 
ATOM   2463 H HG2  . MET A 1 162 ? -17.91094 -33.19293 8.54801   1.000 27.28801  ? 162 MET A HG2  1 
ATOM   2464 H HG3  . MET A 1 162 ? -16.89680 -33.86424 9.57089   1.000 27.28801  ? 162 MET A HG3  1 
ATOM   2465 H HE1  . MET A 1 162 ? -16.77546 -35.96302 10.33993  1.000 30.40728  ? 162 MET A HE1  1 
ATOM   2466 H HE2  . MET A 1 162 ? -18.07760 -36.84561 10.56122  1.000 30.40728  ? 162 MET A HE2  1 
ATOM   2467 H HE3  . MET A 1 162 ? -17.06211 -37.20682 9.39426   1.000 30.40728  ? 162 MET A HE3  1 
ATOM   2468 N N    . HIS A 1 163 ? -16.39771 -30.74904 9.81702   1.000 24.50728  ? 163 HIS A N    1 
ATOM   2469 C CA   . HIS A 1 163 ? -16.01741 -29.60347 9.00238   1.000 22.20538  ? 163 HIS A CA   1 
ATOM   2470 C C    . HIS A 1 163 ? -16.33698 -29.81892 7.52953   1.000 24.83194  ? 163 HIS A C    1 
ATOM   2471 O O    . HIS A 1 163 ? -16.16508 -30.91828 6.99361   1.000 23.78325  ? 163 HIS A O    1 
ATOM   2472 C CB   . HIS A 1 163 ? -14.53147 -29.30092 9.14112   1.000 22.54635  ? 163 HIS A CB   1 
ATOM   2473 C CG   . HIS A 1 163 ? -14.12668 -28.04915 8.43596   1.000 24.06967  ? 163 HIS A CG   1 
ATOM   2474 N ND1  . HIS A 1 163 ? -14.64874 -26.81627 8.76098   1.000 24.70182  ? 163 HIS A ND1  1 
ATOM   2475 C CD2  . HIS A 1 163 ? -13.28916 -27.84152 7.39232   1.000 27.62878  ? 163 HIS A CD2  1 
ATOM   2476 C CE1  . HIS A 1 163 ? -14.12791 -25.89845 7.96595   1.000 28.42756  ? 163 HIS A CE1  1 
ATOM   2477 N NE2  . HIS A 1 163 ? -13.30081 -26.49388 7.12698   1.000 25.45156  ? 163 HIS A NE2  1 
ATOM   2478 H H    . HIS A 1 163 ? -15.74879 -31.27511 10.02134  1.000 29.39578  ? 163 HIS A H    1 
ATOM   2479 H HA   . HIS A 1 163 ? -16.52794 -28.84096 9.31676   1.000 26.63350  ? 163 HIS A HA   1 
ATOM   2480 H HB2  . HIS A 1 163 ? -14.31696 -29.19820 10.08151  1.000 27.04266  ? 163 HIS A HB2  1 
ATOM   2481 H HB3  . HIS A 1 163 ? -14.02336 -30.03574 8.76328   1.000 27.04266  ? 163 HIS A HB3  1 
ATOM   2482 H HD2  . HIS A 1 163 ? -12.79844 -28.48942 6.94030   1.000 33.14158  ? 163 HIS A HD2  1 
ATOM   2483 H HE1  . HIS A 1 163 ? -14.31270 -24.98739 7.99286   1.000 34.10011  ? 163 HIS A HE1  1 
ATOM   2484 H HE2  . HIS A 1 163 ? -12.84329 -26.10152 6.51352   1.000 30.52892  ? 163 HIS A HE2  1 
ATOM   2485 N N    . HIS A 1 164 ? -16.77228 -28.74534 6.86866   1.000 22.83846  ? 164 HIS A N    1 
ATOM   2486 C CA   . HIS A 1 164 ? -17.14724 -28.80321 5.46314   1.000 25.11968  ? 164 HIS A CA   1 
ATOM   2487 C C    . HIS A 1 164 ? -16.53863 -27.69728 4.61099   1.000 26.19882  ? 164 HIS A C    1 
ATOM   2488 O O    . HIS A 1 164 ? -16.20814 -27.94655 3.45019   1.000 27.97908  ? 164 HIS A O    1 
ATOM   2489 C CB   . HIS A 1 164 ? -18.67111 -28.74037 5.31768   1.000 25.11676  ? 164 HIS A CB   1 
ATOM   2490 C CG   . HIS A 1 164 ? -19.37822 -29.99911 5.70928   1.000 25.57412  ? 164 HIS A CG   1 
ATOM   2491 N ND1  . HIS A 1 164 ? -20.00938 -30.81246 4.79426   1.000 22.38872  ? 164 HIS A ND1  1 
ATOM   2492 C CD2  . HIS A 1 164 ? -19.58219 -30.56840 6.92141   1.000 23.49432  ? 164 HIS A CD2  1 
ATOM   2493 C CE1  . HIS A 1 164 ? -20.55942 -31.83622 5.42295   1.000 23.30471  ? 164 HIS A CE1  1 
ATOM   2494 N NE2  . HIS A 1 164 ? -20.31193 -31.71381 6.71430   1.000 22.65307  ? 164 HIS A NE2  1 
ATOM   2495 H H    . HIS A 1 164 ? -16.85882 -27.96504 7.21972   1.000 27.39319  ? 164 HIS A H    1 
ATOM   2496 H HA   . HIS A 1 164 ? -16.82700 -29.65077 5.11674   1.000 30.13066  ? 164 HIS A HA   1 
ATOM   2497 H HB2  . HIS A 1 164 ? -19.00718 -28.02667 5.88212   1.000 30.12716  ? 164 HIS A HB2  1 
ATOM   2498 H HB3  . HIS A 1 164 ? -18.88665 -28.55872 4.38954   1.000 30.12716  ? 164 HIS A HB3  1 
ATOM   2499 H HD1  . HIS A 1 164 ? -20.04061 -30.67531 3.94584   1.000 26.85351  ? 164 HIS A HD1  1 
ATOM   2500 H HD2  . HIS A 1 164 ? -19.28399 -30.24445 7.74058   1.000 28.18023  ? 164 HIS A HD2  1 
ATOM   2501 H HE1  . HIS A 1 164 ? -21.03924 -32.52572 5.02388   1.000 27.95269  ? 164 HIS A HE1  1 
ATOM   2502 N N    . MET A 1 165 ? -16.39934 -26.48146 5.13281   1.000 25.39842  ? 165 MET A N    1 
ATOM   2503 C CA   . MET A 1 165 ? -16.07816 -25.38185 4.23516   1.000 29.32426  ? 165 MET A CA   1 
ATOM   2504 C C    . MET A 1 165 ? -15.55399 -24.17122 4.99135   1.000 30.03543  ? 165 MET A C    1 
ATOM   2505 O O    . MET A 1 165 ? -15.70835 -24.05056 6.20786   1.000 26.24390  ? 165 MET A O    1 
ATOM   2506 C CB   . MET A 1 165 ? -17.31098 -24.98690 3.42274   1.000 31.07951  ? 165 MET A CB   1 
ATOM   2507 C CG   . MET A 1 165 ? -18.38283 -24.32704 4.25690   1.000 30.36432  ? 165 MET A CG   1 
ATOM   2508 S SD   . MET A 1 165 ? -19.98083 -24.30232 3.41980   1.000 44.18629  ? 165 MET A SD   1 
ATOM   2509 C CE   . MET A 1 165 ? -19.52590 -23.63608 1.82097   1.000 39.15721  ? 165 MET A CE   1 
ATOM   2510 H H    . MET A 1 165 ? -16.48238 -26.27939 5.96459   1.000 30.46515  ? 165 MET A H    1 
ATOM   2511 H HA   . MET A 1 165 ? -15.36522 -25.68173 3.64978   1.000 35.17616  ? 165 MET A HA   1 
ATOM   2512 H HB2  . MET A 1 165 ? -17.04428 -24.36241 2.73007   1.000 37.28246  ? 165 MET A HB2  1 
ATOM   2513 H HB3  . MET A 1 165 ? -17.69209 -25.78385 3.02209   1.000 37.28246  ? 165 MET A HB3  1 
ATOM   2514 H HG2  . MET A 1 165 ? -18.48482 -24.81600 5.08841   1.000 36.42423  ? 165 MET A HG2  1 
ATOM   2515 H HG3  . MET A 1 165 ? -18.12373 -23.41052 4.44060   1.000 36.42423  ? 165 MET A HG3  1 
ATOM   2516 H HE1  . MET A 1 165 ? -19.16568 -22.74357 1.94165   1.000 46.97569  ? 165 MET A HE1  1 
ATOM   2517 H HE2  . MET A 1 165 ? -18.85673 -24.21118 1.41801   1.000 46.97569  ? 165 MET A HE2  1 
ATOM   2518 H HE3  . MET A 1 165 ? -20.31463 -23.60104 1.25743   1.000 46.97569  ? 165 MET A HE3  1 
ATOM   2519 N N    . VAL A 1 166 ? -14.92645 -23.27249 4.23115   1.000 31.21598  ? 166 VAL A N    1 
ATOM   2520 C CA   . VAL A 1 166 ? -14.47270 -21.97442 4.71124   1.000 30.65043  ? 166 VAL A CA   1 
ATOM   2521 C C    . VAL A 1 166 ? -15.24717 -20.90255 3.95787   1.000 32.13607  ? 166 VAL A C    1 
ATOM   2522 O O    . VAL A 1 166 ? -15.62692 -21.08639 2.79627   1.000 33.00590  ? 166 VAL A O    1 
ATOM   2523 C CB   . VAL A 1 166 ? -12.95099 -21.78608 4.52132   1.000 32.38362  ? 166 VAL A CB   1 
ATOM   2524 C CG1  . VAL A 1 166 ? -12.58506 -21.92957 3.06256   1.000 31.52097  ? 166 VAL A CG1  1 
ATOM   2525 C CG2  . VAL A 1 166 ? -12.51001 -20.43121 5.04762   1.000 31.65282  ? 166 VAL A CG2  1 
ATOM   2526 H H    . VAL A 1 166 ? -14.74641 -23.40052 3.40001   1.000 37.44623  ? 166 VAL A H    1 
ATOM   2527 H HA   . VAL A 1 166 ? -14.66393 -21.89252 5.65867   1.000 36.76756  ? 166 VAL A HA   1 
ATOM   2528 N N    . LEU A 1 167 ? -15.48585 -19.78377 4.62361   1.000 33.98572  ? 167 LEU A N    1 
ATOM   2529 C CA   . LEU A 1 167 ? -16.25159 -18.67580 4.07210   1.000 34.42309  ? 167 LEU A CA   1 
ATOM   2530 C C    . LEU A 1 167 ? -15.33126 -17.53919 3.65648   1.000 34.75008  ? 167 LEU A C    1 
ATOM   2531 O O    . LEU A 1 167 ? -14.15337 -17.50527 4.02071   1.000 37.41082  ? 167 LEU A O    1 
ATOM   2532 C CB   . LEU A 1 167 ? -17.27326 -18.19040 5.09879   1.000 34.06529  ? 167 LEU A CB   1 
ATOM   2533 C CG   . LEU A 1 167 ? -18.59370 -18.96280 5.09124   1.000 35.39954  ? 167 LEU A CG   1 
ATOM   2534 C CD1  . LEU A 1 167 ? -19.14663 -19.09820 6.49572   1.000 34.11816  ? 167 LEU A CD1  1 
ATOM   2535 C CD2  . LEU A 1 167 ? -19.60399 -18.27013 4.18894   1.000 41.36237  ? 167 LEU A CD2  1 
ATOM   2536 H H    . LEU A 1 167 ? -15.20517 -19.63814 5.42337   1.000 40.76990  ? 167 LEU A H    1 
ATOM   2537 H HA   . LEU A 1 167 ? -16.73105 -18.97544 3.28392   1.000 41.29476  ? 167 LEU A HA   1 
ATOM   2538 H HB2  . LEU A 1 167 ? -16.88658 -18.27796 5.98407   1.000 40.86540  ? 167 LEU A HB2  1 
ATOM   2539 H HB3  . LEU A 1 167 ? -17.47614 -17.25965 4.91595   1.000 40.86540  ? 167 LEU A HB3  1 
ATOM   2540 H HG   . LEU A 1 167 ? -18.43379 -19.85516 4.74624   1.000 42.46650  ? 167 LEU A HG   1 
ATOM   2541 H HD11 . LEU A 1 167 ? -19.93219 -19.66675 6.47239   1.000 40.92884  ? 167 LEU A HD11 1 
ATOM   2542 H HD12 . LEU A 1 167 ? -18.46856 -19.49411 7.06526   1.000 40.92884  ? 167 LEU A HD12 1 
ATOM   2543 H HD13 . LEU A 1 167 ? -19.38481 -18.21838 6.82752   1.000 40.92884  ? 167 LEU A HD13 1 
ATOM   2544 H HD21 . LEU A 1 167 ? -20.43639 -18.76783 4.20642   1.000 49.62190  ? 167 LEU A HD21 1 
ATOM   2545 H HD22 . LEU A 1 167 ? -19.75109 -17.36802 4.51369   1.000 49.62190  ? 167 LEU A HD22 1 
ATOM   2546 H HD23 . LEU A 1 167 ? -19.25362 -18.24320 3.28483   1.000 49.62190  ? 167 LEU A HD23 1 
ATOM   2547 N N    . PRO A 1 168 ? -15.84092 -16.57974 2.87794   1.000 36.21214  ? 168 PRO A N    1 
ATOM   2548 C CA   . PRO A 1 168 ? -14.97077 -15.49915 2.37831   1.000 38.53152  ? 168 PRO A CA   1 
ATOM   2549 C C    . PRO A 1 168 ? -14.22462 -14.75872 3.46948   1.000 35.25627  ? 168 PRO A C    1 
ATOM   2550 O O    . PRO A 1 168 ? -13.12477 -14.24939 3.22135   1.000 36.96345  ? 168 PRO A O    1 
ATOM   2551 C CB   . PRO A 1 168 ? -15.95235 -14.57148 1.64517   1.000 38.45027  ? 168 PRO A CB   1 
ATOM   2552 C CG   . PRO A 1 168 ? -17.08995 -15.45050 1.25493   1.000 36.21756  ? 168 PRO A CG   1 
ATOM   2553 C CD   . PRO A 1 168 ? -17.21404 -16.47736 2.34767   1.000 37.76187  ? 168 PRO A CD   1 
ATOM   2554 H HA   . PRO A 1 168 ? -14.33278 -15.86388 1.74520   1.000 46.22487  ? 168 PRO A HA   1 
ATOM   2555 H HB2  . PRO A 1 168 ? -16.24734 -13.86505 2.24086   1.000 46.12737  ? 168 PRO A HB2  1 
ATOM   2556 H HB3  . PRO A 1 168 ? -15.52447 -14.18895 0.86319   1.000 46.12737  ? 168 PRO A HB3  1 
ATOM   2557 H HG2  . PRO A 1 168 ? -17.90126 -14.92334 1.18584   1.000 43.44812  ? 168 PRO A HG2  1 
ATOM   2558 H HG3  . PRO A 1 168 ? -16.89729 -15.87588 0.40474   1.000 43.44812  ? 168 PRO A HG3  1 
ATOM   2559 H HD2  . PRO A 1 168 ? -17.82788 -16.17627 3.03575   1.000 45.30129  ? 168 PRO A HD2  1 
ATOM   2560 H HD3  . PRO A 1 168 ? -17.50954 -17.32875 1.98891   1.000 45.30129  ? 168 PRO A HD3  1 
ATOM   2561 N N    . THR A 1 169 ? -14.78993 -14.67569 4.67053   1.000 37.44150  ? 169 THR A N    1 
ATOM   2562 C CA   . THR A 1 169 ? -14.15325 -13.96688 5.77163   1.000 38.16871  ? 169 THR A CA   1 
ATOM   2563 C C    . THR A 1 169 ? -13.07760 -14.79071 6.46510   1.000 36.27697  ? 169 THR A C    1 
ATOM   2564 O O    . THR A 1 169 ? -12.45014 -14.29402 7.40645   1.000 40.56832  ? 169 THR A O    1 
ATOM   2565 C CB   . THR A 1 169 ? -15.20819 -13.54133 6.79690   1.000 38.85816  ? 169 THR A CB   1 
ATOM   2566 O OG1  . THR A 1 169 ? -15.97518 -14.68346 7.19505   1.000 40.12989  ? 169 THR A OG1  1 
ATOM   2567 C CG2  . THR A 1 169 ? -16.13783 -12.49918 6.20573   1.000 38.29158  ? 169 THR A CG2  1 
ATOM   2568 H H    . THR A 1 169 ? -15.54910 -15.02536 4.87300   1.000 44.91684  ? 169 THR A H    1 
ATOM   2569 H HA   . THR A 1 169 ? -13.73327 -13.16620 5.42029   1.000 45.78949  ? 169 THR A HA   1 
ATOM   2570 H HB   . THR A 1 169 ? -14.76877 -13.15631 7.57122   1.000 46.61683  ? 169 THR A HB   1 
ATOM   2571 H HG1  . THR A 1 169 ? -16.67206 -14.43670 7.59389   1.000 48.14291  ? 169 THR A HG1  1 
ATOM   2572 H HG21 . THR A 1 169 ? -16.75681 -12.18439 6.88298   1.000 45.93694  ? 169 THR A HG21 1 
ATOM   2573 H HG22 . THR A 1 169 ? -15.62407 -11.74609 5.87437   1.000 45.93694  ? 169 THR A HG22 1 
ATOM   2574 H HG23 . THR A 1 169 ? -16.64273 -12.88311 5.47185   1.000 45.93694  ? 169 THR A HG23 1 
ATOM   2575 N N    . GLY A 1 170 ? -12.84616 -16.02464 6.03157   1.000 35.23917  ? 170 GLY A N    1 
ATOM   2576 C CA   . GLY A 1 170 ? -11.86170 -16.87619 6.65840   1.000 35.34128  ? 170 GLY A CA   1 
ATOM   2577 C C    . GLY A 1 170 ? -12.37912 -17.70827 7.80892   1.000 34.45842  ? 170 GLY A C    1 
ATOM   2578 O O    . GLY A 1 170 ? -11.60151 -18.47748 8.39079   1.000 34.35440  ? 170 GLY A O    1 
ATOM   2579 H H    . GLY A 1 170 ? -13.25422 -16.38959 5.36832   1.000 42.27405  ? 170 GLY A H    1 
ATOM   2580 H HA2  . GLY A 1 170 ? -11.50659 -17.48356 5.99064   1.000 42.39658  ? 170 GLY A HA2  1 
ATOM   2581 H HA3  . GLY A 1 170 ? -11.14110 -16.32128 6.99560   1.000 42.39658  ? 170 GLY A HA3  1 
ATOM   2582 N N    . VAL A 1 171 ? -13.65814 -17.57820 8.16257   1.000 31.27312  ? 171 VAL A N    1 
ATOM   2583 C CA   . VAL A 1 171 ? -14.24647 -18.38279 9.22822   1.000 31.52038  ? 171 VAL A CA   1 
ATOM   2584 C C    . VAL A 1 171 ? -14.84922 -19.63660 8.60802   1.000 27.86884  ? 171 VAL A C    1 
ATOM   2585 O O    . VAL A 1 171 ? -14.92676 -19.76377 7.38248   1.000 29.67824  ? 171 VAL A O    1 
ATOM   2586 C CB   . VAL A 1 171 ? -15.29089 -17.59021 10.03704  1.000 30.83012  ? 171 VAL A CB   1 
ATOM   2587 C CG1  . VAL A 1 171 ? -14.63870 -16.37451 10.68296  1.000 34.69998  ? 171 VAL A CG1  1 
ATOM   2588 C CG2  . VAL A 1 171 ? -16.46694 -17.17865 9.16552   1.000 32.15764  ? 171 VAL A CG2  1 
ATOM   2589 H H    . VAL A 1 171 ? -14.20762 -17.02684 7.79693   1.000 37.51479  ? 171 VAL A H    1 
ATOM   2590 H HA   . VAL A 1 171 ? -13.55022 -18.64857 9.84910   1.000 37.81150  ? 171 VAL A HA   1 
ATOM   2591 H HB   . VAL A 1 171 ? -15.64036 -18.16083 10.73929  1.000 36.98319  ? 171 VAL A HB   1 
ATOM   2592 H HG11 . VAL A 1 171 ? -15.25182 -15.99443 11.33143  1.000 41.62703  ? 171 VAL A HG11 1 
ATOM   2593 H HG12 . VAL A 1 171 ? -13.82072 -16.65210 11.12426  1.000 41.62703  ? 171 VAL A HG12 1 
ATOM   2594 H HG13 . VAL A 1 171 ? -14.43794 -15.72093 9.99490   1.000 41.62703  ? 171 VAL A HG13 1 
ATOM   2595 H HG21 . VAL A 1 171 ? -16.98963 -16.51022 9.63552   1.000 38.57622  ? 171 VAL A HG21 1 
ATOM   2596 H HG22 . VAL A 1 171 ? -16.13002 -16.81037 8.33380   1.000 38.57622  ? 171 VAL A HG22 1 
ATOM   2597 H HG23 . VAL A 1 171 ? -17.01394 -17.95891 8.98421   1.000 38.57622  ? 171 VAL A HG23 1 
ATOM   2598 N N    . HIS A 1 172 ? -15.28953 -20.56416 9.44850   1.000 28.44427  ? 172 HIS A N    1 
ATOM   2599 C CA   . HIS A 1 172 ? -15.53953 -21.93293 9.02696   1.000 28.32015  ? 172 HIS A CA   1 
ATOM   2600 C C    . HIS A 1 172 ? -16.97290 -22.34625 9.32256   1.000 28.40228  ? 172 HIS A C    1 
ATOM   2601 O O    . HIS A 1 172 ? -17.60212 -21.84778 10.25917  1.000 25.08929  ? 172 HIS A O    1 
ATOM   2602 C CB   . HIS A 1 172 ? -14.55010 -22.86973 9.71884   1.000 28.45672  ? 172 HIS A CB   1 
ATOM   2603 C CG   . HIS A 1 172 ? -13.12751 -22.61204 9.33302   1.000 32.07045  ? 172 HIS A CG   1 
ATOM   2604 N ND1  . HIS A 1 172 ? -12.19020 -22.12436 10.21691  1.000 32.51532  ? 172 HIS A ND1  1 
ATOM   2605 C CD2  . HIS A 1 172 ? -12.49101 -22.74378 8.14490   1.000 31.00276  ? 172 HIS A CD2  1 
ATOM   2606 C CE1  . HIS A 1 172 ? -11.03277 -21.98248 9.59523   1.000 31.86105  ? 172 HIS A CE1  1 
ATOM   2607 N NE2  . HIS A 1 172 ? -11.18799 -22.35223 8.33726   1.000 32.64256  ? 172 HIS A NE2  1 
ATOM   2608 H H    . HIS A 1 172 ? -15.45293 -20.42094 10.28060  1.000 34.12017  ? 172 HIS A H    1 
ATOM   2609 H HA   . HIS A 1 172 ? -15.43270 -22.01122 8.06604   1.000 33.97122  ? 172 HIS A HA   1 
ATOM   2610 H HB2  . HIS A 1 172 ? -14.62507 -22.75247 10.67881  1.000 34.13511  ? 172 HIS A HB2  1 
ATOM   2611 H HB3  . HIS A 1 172 ? -14.76351 -23.78500 9.47875   1.000 34.13511  ? 172 HIS A HB3  1 
ATOM   2612 H HD2  . HIS A 1 172 ? -12.86563 -23.04317 7.34809   1.000 37.19036  ? 172 HIS A HD2  1 
ATOM   2613 H HE1  . HIS A 1 172 ? -10.24332 -21.67462 9.97851   1.000 38.22031  ? 172 HIS A HE1  1 
ATOM   2614 H HE2  . HIS A 1 172 ? -10.57329 -22.34859 7.73582   1.000 39.15812  ? 172 HIS A HE2  1 
ATOM   2615 N N    . ALA A 1 173 ? -17.47891 -23.26855 8.50403   1.000 28.26564  ? 173 ALA A N    1 
ATOM   2616 C CA   . ALA A 1 173 ? -18.85543 -23.73102 8.58422   1.000 26.10025  ? 173 ALA A CA   1 
ATOM   2617 C C    . ALA A 1 173 ? -18.89149 -25.24251 8.42892   1.000 26.52506  ? 173 ALA A C    1 
ATOM   2618 O O    . ALA A 1 173 ? -18.05216 -25.83448 7.74188   1.000 25.59402  ? 173 ALA A O    1 
ATOM   2619 C CB   . ALA A 1 173 ? -19.72915 -23.07706 7.50651   1.000 29.41200  ? 173 ALA A CB   1 
ATOM   2620 H H    . ALA A 1 173 ? -17.02888 -23.64949 7.87796   1.000 33.90581  ? 173 ALA A H    1 
ATOM   2621 H HA   . ALA A 1 173 ? -19.22158 -23.50824 9.45440   1.000 31.30735  ? 173 ALA A HA   1 
ATOM   2622 H HB1  . ALA A 1 173 ? -19.32921 -23.23496 6.63702   1.000 35.28145  ? 173 ALA A HB1  1 
ATOM   2623 H HB2  . ALA A 1 173 ? -20.61610 -23.46845 7.53863   1.000 35.28145  ? 173 ALA A HB2  1 
ATOM   2624 H HB3  . ALA A 1 173 ? -19.78182 -22.12383 7.67819   1.000 35.28145  ? 173 ALA A HB3  1 
ATOM   2625 N N    . GLY A 1 174 ? -19.88146 -25.85875 9.05936   1.000 24.90845  ? 174 GLY A N    1 
ATOM   2626 C CA   . GLY A 1 174 ? -19.96832 -27.30203 9.04828   1.000 26.05172  ? 174 GLY A CA   1 
ATOM   2627 C C    . GLY A 1 174 ? -21.30675 -27.77232 9.56773   1.000 26.04873  ? 174 GLY A C    1 
ATOM   2628 O O    . GLY A 1 174 ? -22.23136 -26.98467 9.76469   1.000 26.19664  ? 174 GLY A O    1 
ATOM   2629 H H    . GLY A 1 174 ? -20.50857 -25.46443 9.49622   1.000 29.87718  ? 174 GLY A H    1 
ATOM   2630 H HA2  . GLY A 1 174 ? -19.85490 -27.62861 8.14198   1.000 31.24911  ? 174 GLY A HA2  1 
ATOM   2631 H HA3  . GLY A 1 174 ? -19.26955 -27.67509 9.60815   1.000 31.24911  ? 174 GLY A HA3  1 
ATOM   2632 N N    . THR A 1 175 ? -21.39125 -29.07935 9.79379   1.000 25.88460  ? 175 THR A N    1 
ATOM   2633 C CA   . THR A 1 175 ? -22.63413 -29.73955 10.15531  1.000 26.84130  ? 175 THR A CA   1 
ATOM   2634 C C    . THR A 1 175 ? -22.48917 -30.46895 11.48428  1.000 25.49583  ? 175 THR A C    1 
ATOM   2635 O O    . THR A 1 175 ? -21.38181 -30.71787 11.96785  1.000 23.79095  ? 175 THR A O    1 
ATOM   2636 C CB   . THR A 1 175 ? -23.05153 -30.75645 9.08111   1.000 25.31619  ? 175 THR A CB   1 
ATOM   2637 O OG1  . THR A 1 175 ? -22.14655 -31.86915 9.10544   1.000 24.83322  ? 175 THR A OG1  1 
ATOM   2638 C CG2  . THR A 1 175 ? -23.03659 -30.13211 7.68866   1.000 25.33508  ? 175 THR A CG2  1 
ATOM   2639 H H    . THR A 1 175 ? -20.72195 -29.61688 9.74167   1.000 31.04856  ? 175 THR A H    1 
ATOM   2640 H HA   . THR A 1 175 ? -23.32524 -29.06533 10.24862  1.000 32.19661  ? 175 THR A HA   1 
ATOM   2641 H HB   . THR A 1 175 ? -23.95564 -31.05668 9.26371   1.000 30.36648  ? 175 THR A HB   1 
ATOM   2642 H HG1  . THR A 1 175 ? -22.20323 -32.30133 8.38738   1.000 29.78691  ? 175 THR A HG1  1 
ATOM   2643 H HG21 . THR A 1 175 ? -22.17967 -29.70839 7.52423   1.000 30.38914  ? 175 THR A HG21 1 
ATOM   2644 H HG22 . THR A 1 175 ? -23.18362 -30.81613 7.01679   1.000 30.38914  ? 175 THR A HG22 1 
ATOM   2645 H HG23 . THR A 1 175 ? -23.73675 -29.46464 7.61682   1.000 30.38914  ? 175 THR A HG23 1 
ATOM   2646 N N    . ASP A 1 176 ? -23.63088 -30.82580 12.06219  1.000 24.78519  ? 176 ASP A N    1 
ATOM   2647 C CA   . ASP A 1 176 ? -23.64685 -31.82010 13.12205  1.000 26.28547  ? 176 ASP A CA   1 
ATOM   2648 C C    . ASP A 1 176 ? -23.49838 -33.20115 12.48525  1.000 25.64798  ? 176 ASP A C    1 
ATOM   2649 O O    . ASP A 1 176 ? -23.46734 -33.34252 11.26051  1.000 26.02901  ? 176 ASP A O    1 
ATOM   2650 C CB   . ASP A 1 176 ? -24.91668 -31.69095 13.96383  1.000 26.11268  ? 176 ASP A CB   1 
ATOM   2651 C CG   . ASP A 1 176 ? -26.19516 -31.92818 13.16957  1.000 28.21735  ? 176 ASP A CG   1 
ATOM   2652 O OD1  . ASP A 1 176 ? -26.15602 -32.64101 12.14677  1.000 25.46158  ? 176 ASP A OD1  1 
ATOM   2653 O OD2  . ASP A 1 176 ? -27.25115 -31.39239 13.58425  1.000 26.92715  ? 176 ASP A OD2  1 
ATOM   2654 H H    . ASP A 1 176 ? -24.40334 -30.50754 11.85816  1.000 29.72927  ? 176 ASP A H    1 
ATOM   2655 H HA   . ASP A 1 176 ? -22.90426 -31.67740 13.72959  1.000 31.52960  ? 176 ASP A HA   1 
ATOM   2656 H HB2  . ASP A 1 176 ? -24.88607 -32.34436 14.68008  1.000 31.32226  ? 176 ASP A HB2  1 
ATOM   2657 H HB3  . ASP A 1 176 ? -24.95824 -30.79513 14.33353  1.000 31.32226  ? 176 ASP A HB3  1 
ATOM   2658 N N    . LEU A 1 177 ? -23.39501 -34.23756 13.31234  1.000 23.00728  ? 177 LEU A N    1 
ATOM   2659 C CA   . LEU A 1 177 ? -23.12859 -35.57004 12.78415  1.000 26.26244  ? 177 LEU A CA   1 
ATOM   2660 C C    . LEU A 1 177 ? -24.34489 -36.21145 12.13115  1.000 26.03191  ? 177 LEU A C    1 
ATOM   2661 O O    . LEU A 1 177 ? -24.24827 -37.35688 11.67836  1.000 23.83946  ? 177 LEU A O    1 
ATOM   2662 C CB   . LEU A 1 177 ? -22.58487 -36.47883 13.88722  1.000 25.36499  ? 177 LEU A CB   1 
ATOM   2663 C CG   . LEU A 1 177 ? -21.05520 -36.47293 13.98574  1.000 25.77123  ? 177 LEU A CG   1 
ATOM   2664 C CD1  . LEU A 1 177 ? -20.41998 -37.18097 12.78674  1.000 25.39154  ? 177 LEU A CD1  1 
ATOM   2665 C CD2  . LEU A 1 177 ? -20.52153 -35.04821 14.10174  1.000 26.16591  ? 177 LEU A CD2  1 
ATOM   2666 H H    . LEU A 1 177 ? -23.47391 -34.19465 14.16763  1.000 27.59579  ? 177 LEU A H    1 
ATOM   2667 H HA   . LEU A 1 177 ? -22.44167 -35.49563 12.10334  1.000 31.50197  ? 177 LEU A HA   1 
ATOM   2668 H HB2  . LEU A 1 177 ? -22.93937 -36.18136 14.73972  1.000 30.42504  ? 177 LEU A HB2  1 
ATOM   2669 H HB3  . LEU A 1 177 ? -22.86837 -37.38930 13.70954  1.000 30.42504  ? 177 LEU A HB3  1 
ATOM   2670 H HG   . LEU A 1 177 ? -20.80277 -36.95774 14.78707  1.000 30.91253  ? 177 LEU A HG   1 
ATOM   2671 H HD11 . LEU A 1 177 ? -20.76372 -36.78779 11.96933  1.000 30.45690  ? 177 LEU A HD11 1 
ATOM   2672 H HD12 . LEU A 1 177 ? -19.45727 -37.06969 12.82795  1.000 30.45690  ? 177 LEU A HD12 1 
ATOM   2673 H HD13 . LEU A 1 177 ? -20.64575 -38.12372 12.82073  1.000 30.45690  ? 177 LEU A HD13 1 
ATOM   2674 H HD21 . LEU A 1 177 ? -19.64993 -35.07110 14.52681  1.000 31.38614  ? 177 LEU A HD21 1 
ATOM   2675 H HD22 . LEU A 1 177 ? -20.44642 -34.66581 13.21347  1.000 31.38614  ? 177 LEU A HD22 1 
ATOM   2676 H HD23 . LEU A 1 177 ? -21.13689 -34.52309 14.63699  1.000 31.38614  ? 177 LEU A HD23 1 
ATOM   2677 N N    . GLU A 1 178 ? -25.47803 -35.51394 12.07041  1.000 26.32729  ? 178 GLU A N    1 
ATOM   2678 C CA   . GLU A 1 178 ? -26.59160 -35.92747 11.23152  1.000 28.34099  ? 178 GLU A CA   1 
ATOM   2679 C C    . GLU A 1 178 ? -26.58551 -35.22429 9.88354   1.000 26.42524  ? 178 GLU A C    1 
ATOM   2680 O O    . GLU A 1 178 ? -27.50487 -35.42939 9.08786   1.000 24.71145  ? 178 GLU A O    1 
ATOM   2681 C CB   . GLU A 1 178 ? -27.92477 -35.67189 11.93887  1.000 30.42414  ? 178 GLU A CB   1 
ATOM   2682 C CG   . GLU A 1 178 ? -28.12036 -36.49975 13.19318  1.000 36.69043  ? 178 GLU A CG   1 
ATOM   2683 C CD   . GLU A 1 178 ? -29.56262 -36.50626 13.65939  1.000 47.75855  ? 178 GLU A CD   1 
ATOM   2684 O OE1  . GLU A 1 178 ? -30.37435 -37.25146 13.06942  1.000 43.16229  ? 178 GLU A OE1  1 
ATOM   2685 O OE2  . GLU A 1 178 ? -29.88781 -35.75373 14.60186  1.000 52.78753  ? 178 GLU A OE2  1 
ATOM   2686 H H    . GLU A 1 178 ? -25.62348 -34.79049 12.51208  1.000 31.57980  ? 178 GLU A H    1 
ATOM   2687 H HA   . GLU A 1 178 ? -26.52696 -36.88325 11.07914  1.000 33.99624  ? 178 GLU A HA   1 
ATOM   2688 H HB2  . GLU A 1 178 ? -27.96902 -34.73648 12.19178  1.000 36.49602  ? 178 GLU A HB2  1 
ATOM   2689 H HB3  . GLU A 1 178 ? -28.64750 -35.88493 11.32799  1.000 36.49602  ? 178 GLU A HB3  1 
ATOM   2690 H HG2  . GLU A 1 178 ? -27.85710 -37.41590 13.01355  1.000 44.01556  ? 178 GLU A HG2  1 
ATOM   2691 H HG3  . GLU A 1 178 ? -27.57460 -36.13132 13.90544  1.000 44.01556  ? 178 GLU A HG3  1 
ATOM   2692 N N    . GLY A 1 179 ? -25.57909 -34.39577 9.61530   1.000 26.63740  ? 179 GLY A N    1 
ATOM   2693 C CA   . GLY A 1 179 ? -25.42831 -33.76026 8.32510   1.000 24.55869  ? 179 GLY A CA   1 
ATOM   2694 C C    . GLY A 1 179 ? -26.13776 -32.43550 8.16143   1.000 24.84499  ? 179 GLY A C    1 
ATOM   2695 O O    . GLY A 1 179 ? -26.12970 -31.88590 7.05486   1.000 26.26382  ? 179 GLY A O    1 
ATOM   2696 H H    . GLY A 1 179 ? -24.96374 -34.18673 10.17856  1.000 31.95193  ? 179 GLY A H    1 
ATOM   2697 H HA2  . GLY A 1 179 ? -24.48368 -33.60773 8.16606   1.000 29.45748  ? 179 GLY A HA2  1 
ATOM   2698 H HA3  . GLY A 1 179 ? -25.77015 -34.36110 7.64463   1.000 29.45748  ? 179 GLY A HA3  1 
ATOM   2699 N N    . ASN A 1 180 ? -26.75521 -31.90792 9.21236   1.000 25.54787  ? 180 ASN A N    1 
ATOM   2700 C CA   . ASN A 1 180 ? -27.42661 -30.61551 9.14576   1.000 26.97082  ? 180 ASN A CA   1 
ATOM   2701 C C    . ASN A 1 180 ? -26.43119 -29.51506 9.49265   1.000 26.31432  ? 180 ASN A C    1 
ATOM   2702 O O    . ASN A 1 180 ? -25.83905 -29.52631 10.57666  1.000 26.05414  ? 180 ASN A O    1 
ATOM   2703 C CB   . ASN A 1 180 ? -28.62323 -30.57558 10.09641  1.000 28.81875  ? 180 ASN A CB   1 
ATOM   2704 C CG   . ASN A 1 180 ? -29.68775 -31.59114 9.73306   1.000 28.87446  ? 180 ASN A CG   1 
ATOM   2705 O OD1  . ASN A 1 180 ? -30.32454 -31.49585 8.68503   1.000 31.75885  ? 180 ASN A OD1  1 
ATOM   2706 N ND2  . ASN A 1 180 ? -29.88914 -32.56693 10.60128  1.000 31.16058  ? 180 ASN A ND2  1 
ATOM   2707 H H    . ASN A 1 180 ? -26.79967 -32.28388 9.98455   1.000 30.64449  ? 180 ASN A H    1 
ATOM   2708 H HA   . ASN A 1 180 ? -27.75033 -30.46783 8.24337   1.000 32.35204  ? 180 ASN A HA   1 
ATOM   2709 H HB2  . ASN A 1 180 ? -28.31897 -30.76779 10.99718  1.000 34.56954  ? 180 ASN A HB2  1 
ATOM   2710 H HB3  . ASN A 1 180 ? -29.02515 -29.69339 10.06316  1.000 34.56954  ? 180 ASN A HB3  1 
ATOM   2711 H HD21 . ASN A 1 180 ? -30.48236 -33.16880 10.44176  1.000 37.37975  ? 180 ASN A HD21 1 
ATOM   2712 H HD22 . ASN A 1 180 ? -29.42698 -32.60005 11.32579  1.000 37.37975  ? 180 ASN A HD22 1 
ATOM   2713 N N    . PHE A 1 181 ? -26.25100 -28.56906 8.57399   1.000 24.44077  ? 181 PHE A N    1 
ATOM   2714 C CA   . PHE A 1 181 ? -25.35356 -27.45020 8.82238   1.000 27.77653  ? 181 PHE A CA   1 
ATOM   2715 C C    . PHE A 1 181 ? -25.78311 -26.67021 10.06032  1.000 29.05281  ? 181 PHE A C    1 
ATOM   2716 O O    . PHE A 1 181 ? -26.96465 -26.61025 10.41049  1.000 25.90294  ? 181 PHE A O    1 
ATOM   2717 C CB   . PHE A 1 181 ? -25.32435 -26.50195 7.61868   1.000 29.58487  ? 181 PHE A CB   1 
ATOM   2718 C CG   . PHE A 1 181 ? -24.22587 -26.79688 6.63251   1.000 28.36407  ? 181 PHE A CG   1 
ATOM   2719 C CD1  . PHE A 1 181 ? -24.43318 -27.67080 5.57678   1.000 27.63969  ? 181 PHE A CD1  1 
ATOM   2720 C CD2  . PHE A 1 181 ? -22.98519 -26.19231 6.75966   1.000 29.50244  ? 181 PHE A CD2  1 
ATOM   2721 C CE1  . PHE A 1 181 ? -23.42015 -27.94222 4.67362   1.000 28.55142  ? 181 PHE A CE1  1 
ATOM   2722 C CE2  . PHE A 1 181 ? -21.96855 -26.46180 5.85849   1.000 27.90585  ? 181 PHE A CE2  1 
ATOM   2723 C CZ   . PHE A 1 181 ? -22.18650 -27.33375 4.81542   1.000 28.59863  ? 181 PHE A CZ   1 
ATOM   2724 H H    . PHE A 1 181 ? -26.63474 -28.55347 7.80450   1.000 29.31597  ? 181 PHE A H    1 
ATOM   2725 H HA   . PHE A 1 181 ? -24.45975 -27.79813 8.96711   1.000 33.31888  ? 181 PHE A HA   1 
ATOM   2726 H HB2  . PHE A 1 181 ? -26.16965 -26.57108 7.14794   1.000 35.48888  ? 181 PHE A HB2  1 
ATOM   2727 H HB3  . PHE A 1 181 ? -25.19670 -25.59565 7.93998   1.000 35.48888  ? 181 PHE A HB3  1 
ATOM   2728 H HD1  . PHE A 1 181 ? -25.26230 -28.07937 5.47416   1.000 33.15467  ? 181 PHE A HD1  1 
ATOM   2729 H HD2  . PHE A 1 181 ? -22.83342 -25.59822 7.45889   1.000 35.38998  ? 181 PHE A HD2  1 
ATOM   2730 H HE1  . PHE A 1 181 ? -23.56908 -28.53368 3.97156   1.000 34.24875  ? 181 PHE A HE1  1 
ATOM   2731 H HE2  . PHE A 1 181 ? -21.13875 -26.05383 5.95791   1.000 33.47406  ? 181 PHE A HE2  1 
ATOM   2732 H HZ   . PHE A 1 181 ? -21.50572 -27.51304 4.20773   1.000 34.30540  ? 181 PHE A HZ   1 
ATOM   2733 N N    . TYR A 1 182 ? -24.79799 -26.08572 10.73311  1.000 27.39372  ? 182 TYR A N    1 
ATOM   2734 C CA   . TYR A 1 182 ? -25.05123 -24.96293 11.61995  1.000 28.51290  ? 182 TYR A CA   1 
ATOM   2735 C C    . TYR A 1 182 ? -25.14926 -23.70575 10.76787  1.000 29.01091  ? 182 TYR A C    1 
ATOM   2736 O O    . TYR A 1 182 ? -24.25917 -23.42969 9.95744   1.000 31.74571  ? 182 TYR A O    1 
ATOM   2737 C CB   . TYR A 1 182 ? -23.93890 -24.82069 12.65745  1.000 27.03844  ? 182 TYR A CB   1 
ATOM   2738 C CG   . TYR A 1 182 ? -23.88168 -25.94328 13.65978  1.000 26.81863  ? 182 TYR A CG   1 
ATOM   2739 C CD1  . TYR A 1 182 ? -24.59682 -25.87490 14.85294  1.000 28.78920  ? 182 TYR A CD1  1 
ATOM   2740 C CD2  . TYR A 1 182 ? -23.10922 -27.07221 13.42042  1.000 25.63485  ? 182 TYR A CD2  1 
ATOM   2741 C CE1  . TYR A 1 182 ? -24.54567 -26.90046 15.77323  1.000 29.31054  ? 182 TYR A CE1  1 
ATOM   2742 C CE2  . TYR A 1 182 ? -23.05353 -28.10464 14.33546  1.000 27.89906  ? 182 TYR A CE2  1 
ATOM   2743 C CZ   . TYR A 1 182 ? -23.77382 -28.01567 15.50838  1.000 27.10898  ? 182 TYR A CZ   1 
ATOM   2744 O OH   . TYR A 1 182 ? -23.72021 -29.04043 16.42331  1.000 26.76601  ? 182 TYR A OH   1 
ATOM   2745 H H    . TYR A 1 182 ? -23.97243 -26.32305 10.69157  1.000 32.85950  ? 182 TYR A H    1 
ATOM   2746 H HA   . TYR A 1 182 ? -25.87830 -25.09688 12.10876  1.000 34.20253  ? 182 TYR A HA   1 
ATOM   2747 H HB2  . TYR A 1 182 ? -23.08605 -24.79460 12.19607  1.000 32.43318  ? 182 TYR A HB2  1 
ATOM   2748 H HB3  . TYR A 1 182 ? -24.07613 -23.99517 13.14795  1.000 32.43318  ? 182 TYR A HB3  1 
ATOM   2749 H HD1  . TYR A 1 182 ? -25.11736 -25.12530 15.03190  1.000 34.53408  ? 182 TYR A HD1  1 
ATOM   2750 H HD2  . TYR A 1 182 ? -22.62151 -27.13384 12.63097  1.000 30.74886  ? 182 TYR A HD2  1 
ATOM   2751 H HE1  . TYR A 1 182 ? -25.02728 -26.84203 16.56667  1.000 35.15969  ? 182 TYR A HE1  1 
ATOM   2752 H HE2  . TYR A 1 182 ? -22.53333 -28.85576 14.16195  1.000 33.46592  ? 182 TYR A HE2  1 
ATOM   2753 H HH   . TYR A 1 182 ? -23.45719 -29.74544 16.04997  1.000 32.10626  ? 182 TYR A HH   1 
ATOM   2754 N N    . GLY A 1 183 ? -26.23601 -22.95845 10.93101  1.000 30.37480  ? 183 GLY A N    1 
ATOM   2755 C CA   . GLY A 1 183 ? -26.43827 -21.74711 10.17338  1.000 30.75762  ? 183 GLY A CA   1 
ATOM   2756 C C    . GLY A 1 183 ? -27.14164 -22.00345 8.85568   1.000 33.13072  ? 183 GLY A C    1 
ATOM   2757 O O    . GLY A 1 183 ? -27.59416 -23.11922 8.57692   1.000 27.95712  ? 183 GLY A O    1 
ATOM   2758 H H    . GLY A 1 183 ? -26.87181 -23.13976 11.48099  1.000 36.43681  ? 183 GLY A H    1 
ATOM   2759 H HA2  . GLY A 1 183 ? -26.97667 -21.12944 10.69251  1.000 36.89619  ? 183 GLY A HA2  1 
ATOM   2760 H HA3  . GLY A 1 183 ? -25.57904 -21.33739 9.98693   1.000 36.89619  ? 183 GLY A HA3  1 
ATOM   2761 N N    . PRO A 1 184 ? -27.23183 -20.97610 8.01301   1.000 31.16133  ? 184 PRO A N    1 
ATOM   2762 C CA   . PRO A 1 184 ? -27.94414 -21.09295 6.73238   1.000 35.93497  ? 184 PRO A CA   1 
ATOM   2763 C C    . PRO A 1 184 ? -27.09767 -21.60912 5.57885   1.000 34.42370  ? 184 PRO A C    1 
ATOM   2764 O O    . PRO A 1 184 ? -27.55130 -21.54768 4.43214   1.000 33.18344  ? 184 PRO A O    1 
ATOM   2765 C CB   . PRO A 1 184 ? -28.36636 -19.64031 6.46618   1.000 39.47376  ? 184 PRO A CB   1 
ATOM   2766 C CG   . PRO A 1 184 ? -27.33733 -18.78683 7.20067   1.000 37.45540  ? 184 PRO A CG   1 
ATOM   2767 C CD   . PRO A 1 184 ? -26.53527 -19.68311 8.11384   1.000 36.68344  ? 184 PRO A CD   1 
ATOM   2768 H HA   . PRO A 1 184 ? -28.73459 -21.64689 6.82850   1.000 43.10900  ? 184 PRO A HA   1 
ATOM   2769 H HB2  . PRO A 1 184 ? -28.34874 -19.46114 5.51303   1.000 47.35556  ? 184 PRO A HB2  1 
ATOM   2770 H HB3  . PRO A 1 184 ? -29.25784 -19.48656 6.81622   1.000 47.35556  ? 184 PRO A HB3  1 
ATOM   2771 H HG2  . PRO A 1 184 ? -26.75408 -18.36519 6.55034   1.000 44.93352  ? 184 PRO A HG2  1 
ATOM   2772 H HG3  . PRO A 1 184 ? -27.79997 -18.11016 7.71930   1.000 44.93352  ? 184 PRO A HG3  1 
ATOM   2773 H HD2  . PRO A 1 184 ? -25.61878 -19.75938 7.80542   1.000 44.00717  ? 184 PRO A HD2  1 
ATOM   2774 H HD3  . PRO A 1 184 ? -26.55210 -19.35171 9.02531   1.000 44.00717  ? 184 PRO A HD3  1 
ATOM   2775 N N    . PHE A 1 185 ? -25.90150 -22.11297 5.85568   1.000 32.54672  ? 185 PHE A N    1 
ATOM   2776 C CA   . PHE A 1 185 ? -24.93961 -22.42396 4.81592   1.000 32.21504  ? 185 PHE A CA   1 
ATOM   2777 C C    . PHE A 1 185 ? -25.27534 -23.75015 4.14263   1.000 30.59150  ? 185 PHE A C    1 
ATOM   2778 O O    . PHE A 1 185 ? -25.98814 -24.59599 4.68695   1.000 29.80415  ? 185 PHE A O    1 
ATOM   2779 C CB   . PHE A 1 185 ? -23.53332 -22.45936 5.41060   1.000 33.08804  ? 185 PHE A CB   1 
ATOM   2780 C CG   . PHE A 1 185 ? -23.22832 -21.27755 6.29014   1.000 33.13295  ? 185 PHE A CG   1 
ATOM   2781 C CD1  . PHE A 1 185 ? -23.09100 -20.01440 5.74293   1.000 35.35355  ? 185 PHE A CD1  1 
ATOM   2782 C CD2  . PHE A 1 185 ? -23.09655 -21.42658 7.66336   1.000 33.63499  ? 185 PHE A CD2  1 
ATOM   2783 C CE1  . PHE A 1 185 ? -22.81990 -18.91979 6.54604   1.000 40.13585  ? 185 PHE A CE1  1 
ATOM   2784 C CE2  . PHE A 1 185 ? -22.82339 -20.33525 8.47136   1.000 34.27925  ? 185 PHE A CE2  1 
ATOM   2785 C CZ   . PHE A 1 185 ? -22.68509 -19.08130 7.90996   1.000 38.58992  ? 185 PHE A CZ   1 
ATOM   2786 H H    . PHE A 1 185 ? -25.62132 -22.28543 6.65026   1.000 39.04311  ? 185 PHE A H    1 
ATOM   2787 H HA   . PHE A 1 185 ? -24.96299 -21.74039 4.12811   1.000 38.64509  ? 185 PHE A HA   1 
ATOM   2788 H HB2  . PHE A 1 185 ? -23.43996 -23.26199 5.94723   1.000 39.69269  ? 185 PHE A HB2  1 
ATOM   2789 H HB3  . PHE A 1 185 ? -22.88713 -22.46691 4.68721   1.000 39.69269  ? 185 PHE A HB3  1 
ATOM   2790 H HD1  . PHE A 1 185 ? -23.18190 -19.89918 4.82458   1.000 42.41131  ? 185 PHE A HD1  1 
ATOM   2791 H HD2  . PHE A 1 185 ? -23.19276 -22.26891 8.04562   1.000 40.34903  ? 185 PHE A HD2  1 
ATOM   2792 H HE1  . PHE A 1 185 ? -22.72863 -18.07571 6.16644   1.000 48.15006  ? 185 PHE A HE1  1 
ATOM   2793 H HE2  . PHE A 1 185 ? -22.73329 -20.44683 9.39024   1.000 41.12214  ? 185 PHE A HE2  1 
ATOM   2794 H HZ   . PHE A 1 185 ? -22.50141 -18.34683 8.45006   1.000 46.29495  ? 185 PHE A HZ   1 
ATOM   2795 N N    . VAL A 1 186 ? -24.75739 -23.91403 2.92569   1.000 29.76963  ? 186 VAL A N    1 
ATOM   2796 C CA   . VAL A 1 186 ? -24.95979 -25.12414 2.14170   1.000 30.30574  ? 186 VAL A CA   1 
ATOM   2797 C C    . VAL A 1 186 ? -23.62547 -25.52306 1.52845   1.000 29.35480  ? 186 VAL A C    1 
ATOM   2798 O O    . VAL A 1 186 ? -22.75453 -24.68128 1.28906   1.000 29.43102  ? 186 VAL A O    1 
ATOM   2799 C CB   . VAL A 1 186 ? -26.03937 -24.92977 1.05369   1.000 31.30553  ? 186 VAL A CB   1 
ATOM   2800 C CG1  . VAL A 1 186 ? -27.33602 -24.44894 1.68222   1.000 31.02998  ? 186 VAL A CG1  1 
ATOM   2801 C CG2  . VAL A 1 186 ? -25.56754 -23.95069 -0.01560  1.000 34.54486  ? 186 VAL A CG2  1 
ATOM   2802 H H    . VAL A 1 186 ? -24.27528 -23.32382 2.52717   1.000 35.71060  ? 186 VAL A H    1 
ATOM   2803 H HA   . VAL A 1 186 ? -25.25291 -25.84433 2.72162   1.000 36.35393  ? 186 VAL A HA   1 
ATOM   2804 H HB   . VAL A 1 186 ? -26.20280 -25.78272 0.62165   1.000 37.55368  ? 186 VAL A HB   1 
ATOM   2805 H HG11 . VAL A 1 186 ? -28.04841 -24.51634 1.02735   1.000 37.22303  ? 186 VAL A HG11 1 
ATOM   2806 H HG12 . VAL A 1 186 ? -27.53953 -25.00467 2.45075   1.000 37.22303  ? 186 VAL A HG12 1 
ATOM   2807 H HG13 . VAL A 1 186 ? -27.22880 -23.52594 1.96055   1.000 37.22303  ? 186 VAL A HG13 1 
ATOM   2808 H HG21 . VAL A 1 186 ? -24.71889 -23.56891 0.25815   1.000 41.44088  ? 186 VAL A HG21 1 
ATOM   2809 H HG22 . VAL A 1 186 ? -25.46114 -24.42620 -0.85433  1.000 41.44088  ? 186 VAL A HG22 1 
ATOM   2810 H HG23 . VAL A 1 186 ? -26.22938 -23.24858 -0.11507  1.000 41.44088  ? 186 VAL A HG23 1 
ATOM   2811 N N    . ASP A 1 187 ? -23.46473 -26.82261 1.27955   1.000 29.70854  ? 187 ASP A N    1 
ATOM   2812 C CA   . ASP A 1 187 ? -22.19077 -27.35782 0.79858   1.000 31.02904  ? 187 ASP A CA   1 
ATOM   2813 C C    . ASP A 1 187 ? -22.12131 -27.24104 -0.72672  1.000 31.96766  ? 187 ASP A C    1 
ATOM   2814 O O    . ASP A 1 187 ? -22.19862 -28.21620 -1.47423  1.000 28.71881  ? 187 ASP A O    1 
ATOM   2815 C CB   . ASP A 1 187 ? -21.99822 -28.79455 1.27511   1.000 29.24256  ? 187 ASP A CB   1 
ATOM   2816 C CG   . ASP A 1 187 ? -23.16871 -29.69785 0.93002   1.000 28.06300  ? 187 ASP A CG   1 
ATOM   2817 O OD1  . ASP A 1 187 ? -24.28282 -29.18428 0.68594   1.000 29.54213  ? 187 ASP A OD1  1 
ATOM   2818 O OD2  . ASP A 1 187 ? -22.97602 -30.92984 0.91462   1.000 28.71906  ? 187 ASP A OD2  1 
ATOM   2819 H H    . ASP A 1 187 ? -24.07922 -27.41557 1.38151   1.000 35.63730  ? 187 ASP A H    1 
ATOM   2820 H HA   . ASP A 1 187 ? -21.47094 -26.82300 1.16833   1.000 37.22189  ? 187 ASP A HA   1 
ATOM   2821 H HB2  . ASP A 1 187 ? -21.20413 -29.16155 0.85602   1.000 35.07811  ? 187 ASP A HB2  1 
ATOM   2822 H HB3  . ASP A 1 187 ? -21.89476 -28.79521 2.23958   1.000 35.07811  ? 187 ASP A HB3  1 
ATOM   2823 N N    . ARG A 1 188 ? -21.95849 -25.99687 -1.17430  1.000 33.96925  ? 188 ARG A N    1 
ATOM   2824 C CA   . ARG A 1 188 ? -21.71244 -25.68791 -2.57557  1.000 38.29988  ? 188 ARG A CA   1 
ATOM   2825 C C    . ARG A 1 188 ? -20.87964 -24.41450 -2.62911  1.000 39.75056  ? 188 ARG A C    1 
ATOM   2826 O O    . ARG A 1 188 ? -20.89668 -23.60496 -1.69990  1.000 36.41075  ? 188 ARG A O    1 
ATOM   2827 C CB   . ARG A 1 188 ? -23.02213 -25.52479 -3.35988  1.000 43.00150  ? 188 ARG A CB   1 
ATOM   2828 C CG   . ARG A 1 188 ? -23.65578 -24.14924 -3.23923  1.000 47.58199  ? 188 ARG A CG   1 
ATOM   2829 C CD   . ARG A 1 188 ? -25.06090 -24.07890 -3.83224  1.000 57.35884  ? 188 ARG A CD   1 
ATOM   2830 N NE   . ARG A 1 188 ? -25.38323 -25.19986 -4.70956  1.000 77.24064  ? 188 ARG A NE   1 
ATOM   2831 C CZ   . ARG A 1 188 ? -25.99876 -26.31431 -4.32682  1.000 72.14351  ? 188 ARG A CZ   1 
ATOM   2832 N NH1  . ARG A 1 188 ? -26.35304 -26.51729 -3.06487  1.000 58.90181  ? 188 ARG A NH1  1 
ATOM   2833 N NH2  . ARG A 1 188 ? -26.26447 -27.25193 -5.23407  1.000 56.91396  ? 188 ARG A NH2  1 
ATOM   2834 H H    . ARG A 1 188 ? -21.98727 -25.29946 -0.67192  1.000 40.75015  ? 188 ARG A H    1 
ATOM   2835 H HA   . ARG A 1 188 ? -21.21265 -26.40551 -2.99529  1.000 45.94690  ? 188 ARG A HA   1 
ATOM   2836 H HB2  . ARG A 1 188 ? -22.84223 -25.68405 -4.29965  1.000 51.58885  ? 188 ARG A HB2  1 
ATOM   2837 H HB3  . ARG A 1 188 ? -23.66339 -26.17366 -3.03024  1.000 51.58885  ? 188 ARG A HB3  1 
ATOM   2838 H HG2  . ARG A 1 188 ? -23.71686 -23.91221 -2.30062  1.000 57.08543  ? 188 ARG A HG2  1 
ATOM   2839 H HG3  . ARG A 1 188 ? -23.10229 -23.50562 -3.70860  1.000 57.08543  ? 188 ARG A HG3  1 
ATOM   2840 H HD2  . ARG A 1 188 ? -25.70621 -24.07488 -3.10805  1.000 68.81766  ? 188 ARG A HD2  1 
ATOM   2841 H HD3  . ARG A 1 188 ? -25.14057 -23.26387 -4.35212  1.000 68.81766  ? 188 ARG A HD3  1 
ATOM   2842 H HE   . ARG A 1 188 ? -25.15786 -25.13448 -5.53692  1.000 92.67582  ? 188 ARG A HE   1 
ATOM   2843 H HH11 . ARG A 1 188 ? -26.18547 -25.91953 -2.46973  1.000 70.66921  ? 188 ARG A HH11 1 
ATOM   2844 H HH12 . ARG A 1 188 ? -26.75032 -27.24667 -2.84178  1.000 70.66921  ? 188 ARG A HH12 1 
ATOM   2845 H HH21 . ARG A 1 188 ? -26.03835 -27.13218 -6.05512  1.000 68.28380  ? 188 ARG A HH21 1 
ATOM   2846 H HH22 . ARG A 1 188 ? -26.66222 -27.97728 -4.99900  1.000 68.28380  ? 188 ARG A HH22 1 
ATOM   2847 N N    . GLN A 1 189 ? -20.14589 -24.24258 -3.72707  1.000 41.01906  ? 189 GLN A N    1 
ATOM   2848 C CA   . GLN A 1 189 ? -19.24100 -23.10136 -3.87764  1.000 42.29304  ? 189 GLN A CA   1 
ATOM   2849 C C    . GLN A 1 189 ? -19.94162 -21.98195 -4.64569  1.000 46.24723  ? 189 GLN A C    1 
ATOM   2850 O O    . GLN A 1 189 ? -19.60737 -21.64399 -5.78395  1.000 49.56038  ? 189 GLN A O    1 
ATOM   2851 C CB   . GLN A 1 189 ? -17.94589 -23.53881 -4.55666  1.000 40.18661  ? 189 GLN A CB   1 
ATOM   2852 C CG   . GLN A 1 189 ? -16.93424 -24.12608 -3.58325  1.000 38.50808  ? 189 GLN A CG   1 
ATOM   2853 C CD   . GLN A 1 189 ? -15.76444 -24.82462 -4.25980  1.000 39.20882  ? 189 GLN A CD   1 
ATOM   2854 O OE1  . GLN A 1 189 ? -15.02289 -25.56504 -3.61121  1.000 38.71964  ? 189 GLN A OE1  1 
ATOM   2855 N NE2  . GLN A 1 189 ? -15.58972 -24.59164 -5.55933  1.000 40.62773  ? 189 GLN A NE2  1 
ATOM   2856 H H    . GLN A 1 189 ? -20.15355 -24.77478 -4.40257  1.000 49.20992  ? 189 GLN A H    1 
ATOM   2857 H HA   . GLN A 1 189 ? -19.01761 -22.76173 -2.99693  1.000 50.73870  ? 189 GLN A HA   1 
ATOM   2858 H HB2  . GLN A 1 189 ? -18.15134 -24.21606 -5.22000  1.000 48.21098  ? 189 GLN A HB2  1 
ATOM   2859 H HB3  . GLN A 1 189 ? -17.53865 -22.76893 -4.98368  1.000 48.21098  ? 189 GLN A HB3  1 
ATOM   2860 H HG2  . GLN A 1 189 ? -16.57465 -23.40969 -3.03701  1.000 46.19674  ? 189 GLN A HG2  1 
ATOM   2861 H HG3  . GLN A 1 189 ? -17.38306 -24.77778 -3.02223  1.000 46.19674  ? 189 GLN A HG3  1 
ATOM   2862 H HE21 . GLN A 1 189 ? -16.12642 -24.06596 -5.97791  1.000 48.74032  ? 189 GLN A HE21 1 
ATOM   2863 H HE22 . GLN A 1 189 ? -14.94018 -24.96686 -5.97993  1.000 48.74032  ? 189 GLN A HE22 1 
ATOM   2864 N N    . THR A 1 190 ? -20.93835 -21.40723 -3.98310  1.000 46.33236  ? 190 THR A N    1 
ATOM   2865 C CA   . THR A 1 190 ? -21.67209 -20.25497 -4.48326  1.000 49.18340  ? 190 THR A CA   1 
ATOM   2866 C C    . THR A 1 190 ? -21.45217 -19.07812 -3.53861  1.000 52.80498  ? 190 THR A C    1 
ATOM   2867 O O    . THR A 1 190 ? -20.82014 -19.20213 -2.48521  1.000 52.03289  ? 190 THR A O    1 
ATOM   2868 C CB   . THR A 1 190 ? -23.16893 -20.56077 -4.62354  1.000 53.14821  ? 190 THR A CB   1 
ATOM   2869 O OG1  . THR A 1 190 ? -23.76256 -19.64785 -5.55803  1.000 61.61246  ? 190 THR A OG1  1 
ATOM   2870 C CG2  . THR A 1 190 ? -23.87728 -20.43164 -3.27989  1.000 51.34062  ? 190 THR A CG2  1 
ATOM   2871 H H    . THR A 1 190 ? -21.21583 -21.67777 -3.21537  1.000 55.58588  ? 190 THR A H    1 
ATOM   2872 H HA   . THR A 1 190 ? -21.33211 -20.02543 -5.36226  1.000 59.00713  ? 190 THR A HA   1 
ATOM   2873 H HB   . THR A 1 190 ? -23.27962 -21.47073 -4.94076  1.000 63.76490  ? 190 THR A HB   1 
ATOM   2874 H HG1  . THR A 1 190 ? -24.56393 -19.85853 -5.69593  1.000 73.92199  ? 190 THR A HG1  1 
ATOM   2875 H HG21 . THR A 1 190 ? -24.01912 -19.49570 -3.06822  1.000 61.59579  ? 190 THR A HG21 1 
ATOM   2876 H HG22 . THR A 1 190 ? -24.73650 -20.88055 -3.31333  1.000 61.59579  ? 190 THR A HG22 1 
ATOM   2877 H HG23 . THR A 1 190 ? -23.33869 -20.83436 -2.58086  1.000 61.59579  ? 190 THR A HG23 1 
ATOM   2878 N N    . ALA A 1 191 ? -21.98522 -17.92400 -3.92637  1.000 54.60095  ? 191 ALA A N    1 
ATOM   2879 C CA   . ALA A 1 191 ? -21.88147 -16.72764 -3.09949  1.000 55.77753  ? 191 ALA A CA   1 
ATOM   2880 C C    . ALA A 1 191 ? -22.72267 -16.90854 -1.84096  1.000 53.96887  ? 191 ALA A C    1 
ATOM   2881 O O    . ALA A 1 191 ? -23.95311 -17.00197 -1.91432  1.000 53.76694  ? 191 ALA A O    1 
ATOM   2882 C CB   . ALA A 1 191 ? -22.32977 -15.49964 -3.88512  1.000 50.55049  ? 191 ALA A CB   1 
ATOM   2883 H H    . ALA A 1 191 ? -22.41192 -17.80810 -4.66400  1.000 65.50818  ? 191 ALA A H    1 
ATOM   2884 H HA   . ALA A 1 191 ? -20.95622 -16.59801 -2.83870  1.000 66.92009  ? 191 ALA A HA   1 
ATOM   2885 H HB1  . ALA A 1 191 ? -22.24411 -14.71523 -3.32098  1.000 60.64763  ? 191 ALA A HB1  1 
ATOM   2886 H HB2  . ALA A 1 191 ? -21.76854 -15.40505 -4.67060  1.000 60.64763  ? 191 ALA A HB2  1 
ATOM   2887 H HB3  . ALA A 1 191 ? -23.25512 -15.61584 -4.15180  1.000 60.64763  ? 191 ALA A HB3  1 
ATOM   2888 N N    . GLN A 1 192 ? -22.05997 -16.96995 -0.68741  1.000 51.13299  ? 192 GLN A N    1 
ATOM   2889 C CA   . GLN A 1 192 ? -22.74170 -17.04334 0.59812   1.000 50.33936  ? 192 GLN A CA   1 
ATOM   2890 C C    . GLN A 1 192 ? -21.79776 -16.50521 1.66269   1.000 46.45920  ? 192 GLN A C    1 
ATOM   2891 O O    . GLN A 1 192 ? -20.59982 -16.79976 1.63857   1.000 47.26193  ? 192 GLN A O    1 
ATOM   2892 C CB   . GLN A 1 192 ? -23.17974 -18.47653 0.92928   1.000 50.64288  ? 192 GLN A CB   1 
ATOM   2893 C CG   . GLN A 1 192 ? -22.11724 -19.53855 0.69788   1.000 52.86995  ? 192 GLN A CG   1 
ATOM   2894 C CD   . GLN A 1 192 ? -22.62621 -20.94238 0.97509   1.000 42.32935  ? 192 GLN A CD   1 
ATOM   2895 O OE1  . GLN A 1 192 ? -23.35851 -21.17262 1.93362   1.000 33.95788  ? 192 GLN A OE1  1 
ATOM   2896 N NE2  . GLN A 1 192 ? -22.24401 -21.88591 0.12868   1.000 40.71743  ? 192 GLN A NE2  1 
ATOM   2897 H H    . GLN A 1 192 ? -21.20233 -16.97048 -0.62378  1.000 61.34663  ? 192 GLN A H    1 
ATOM   2898 H HA   . GLN A 1 192 ? -23.53985 -16.49234 0.58207   1.000 60.39427  ? 192 GLN A HA   1 
ATOM   2899 H HB2  . GLN A 1 192 ? -23.42941 -18.51318 1.86588   1.000 60.75851  ? 192 GLN A HB2  1 
ATOM   2900 H HB3  . GLN A 1 192 ? -23.94238 -18.70122 0.37359   1.000 60.75851  ? 192 GLN A HB3  1 
ATOM   2901 H HG2  . GLN A 1 192 ? -21.82774 -19.50081 -0.22714  1.000 63.43098  ? 192 GLN A HG2  1 
ATOM   2902 H HG3  . GLN A 1 192 ? -21.36610 -19.36905 1.28777   1.000 63.43098  ? 192 GLN A HG3  1 
ATOM   2903 H HE21 . GLN A 1 192 ? -21.73418 -21.68749 -0.53487  1.000 48.84796  ? 192 GLN A HE21 1 
ATOM   2904 H HE22 . GLN A 1 192 ? -22.50557 -22.69723 0.24242   1.000 48.84796  ? 192 GLN A HE22 1 
ATOM   2905 N N    . ALA A 1 193 ? -22.34089 -15.71514 2.58713   1.000 43.18818  ? 193 ALA A N    1 
ATOM   2906 C CA   . ALA A 1 193 ? -21.53846 -15.00305 3.56970   1.000 46.67865  ? 193 ALA A CA   1 
ATOM   2907 C C    . ALA A 1 193 ? -22.11593 -15.21245 4.96373   1.000 48.02922  ? 193 ALA A C    1 
ATOM   2908 O O    . ALA A 1 193 ? -23.21618 -15.74518 5.13920   1.000 46.60488  ? 193 ALA A O    1 
ATOM   2909 C CB   . ALA A 1 193 ? -21.45035 -13.50788 3.23352   1.000 45.91050  ? 193 ALA A CB   1 
ATOM   2910 H H    . ALA A 1 193 ? -23.18610 -15.57587 2.66343   1.000 51.81286  ? 193 ALA A H    1 
ATOM   2911 H HA   . ALA A 1 193 ? -20.63947 -15.36736 3.57189   1.000 56.00143  ? 193 ALA A HA   1 
ATOM   2912 H HB1  . ALA A 1 193 ? -22.34633 -13.13733 3.20474   1.000 55.07964  ? 193 ALA A HB1  1 
ATOM   2913 H HB2  . ALA A 1 193 ? -20.92918 -13.06038 3.91838   1.000 55.07964  ? 193 ALA A HB2  1 
ATOM   2914 H HB3  . ALA A 1 193 ? -21.02117 -13.40311 2.36997   1.000 55.07964  ? 193 ALA A HB3  1 
ATOM   2915 N N    . ALA A 1 194 ? -21.35830 -14.75314 5.96122   1.000 46.87012  ? 194 ALA A N    1 
ATOM   2916 C CA   . ALA A 1 194 ? -21.50893 -15.25289 7.32375   1.000 41.83082  ? 194 ALA A CA   1 
ATOM   2917 C C    . ALA A 1 194 ? -22.68319 -14.61690 8.06080   1.000 45.23693  ? 194 ALA A C    1 
ATOM   2918 O O    . ALA A 1 194 ? -23.56139 -15.32339 8.56831   1.000 47.54084  ? 194 ALA A O    1 
ATOM   2919 C CB   . ALA A 1 194 ? -20.20882 -15.02133 8.09964   1.000 38.96894  ? 194 ALA A CB   1 
ATOM   2920 H H    . ALA A 1 194 ? -20.74987 -14.15171 5.87347   1.000 56.23120  ? 194 ALA A H    1 
ATOM   2921 H HA   . ALA A 1 194 ? -21.68741 -16.20502 7.27385   1.000 50.18403  ? 194 ALA A HA   1 
ATOM   2922 H HB1  . ALA A 1 194 ? -19.49120 -15.50924 7.66620   1.000 46.74977  ? 194 ALA A HB1  1 
ATOM   2923 H HB2  . ALA A 1 194 ? -20.00823 -14.07231 8.10371   1.000 46.74977  ? 194 ALA A HB2  1 
ATOM   2924 H HB3  . ALA A 1 194 ? -20.32283 -15.33922 9.00895   1.000 46.74977  ? 194 ALA A HB3  1 
ATOM   2925 N N    . GLY A 1 195 ? -22.70586 -13.29444 8.14760   1.000 41.57205  ? 195 GLY A N    1 
ATOM   2926 C CA   . GLY A 1 195 ? -23.58674 -12.58796 9.05299   1.000 38.59563  ? 195 GLY A CA   1 
ATOM   2927 C C    . GLY A 1 195 ? -22.81235 -11.93994 10.19493  1.000 36.88784  ? 195 GLY A C    1 
ATOM   2928 O O    . GLY A 1 195 ? -21.66375 -12.28231 10.48575  1.000 34.35767  ? 195 GLY A O    1 
ATOM   2929 H H    . GLY A 1 195 ? -22.20628 -12.77443 7.67897   1.000 49.87350  ? 195 GLY A H    1 
ATOM   2930 H HA2  . GLY A 1 195 ? -24.06156 -11.89447 8.56872   1.000 46.30180  ? 195 GLY A HA2  1 
ATOM   2931 H HA3  . GLY A 1 195 ? -24.23088 -13.20812 9.42902   1.000 46.30180  ? 195 GLY A HA3  1 
ATOM   2932 N N    . THR A 1 196 ? -23.46427 -10.98318 10.85275  1.000 36.92981  ? 196 THR A N    1 
ATOM   2933 C CA   . THR A 1 196 ? -22.79358 -10.22218 11.89962  1.000 38.45996  ? 196 THR A CA   1 
ATOM   2934 C C    . THR A 1 196 ? -22.26655 -11.15125 12.98756  1.000 34.42473  ? 196 THR A C    1 
ATOM   2935 O O    . THR A 1 196 ? -23.01765 -11.93818 13.56870  1.000 33.81247  ? 196 THR A O    1 
ATOM   2936 C CB   . THR A 1 196 ? -23.74433 -9.19294  12.50960  1.000 41.93740  ? 196 THR A CB   1 
ATOM   2937 O OG1  . THR A 1 196 ? -24.17650 -8.27275  11.49993  1.000 37.57976  ? 196 THR A OG1  1 
ATOM   2938 C CG2  . THR A 1 196 ? -23.04478 -8.43269  13.62535  1.000 39.18985  ? 196 THR A CG2  1 
ATOM   2939 H H    . THR A 1 196 ? -24.28286 -10.75947 10.71324  1.000 44.30282  ? 196 THR A H    1 
ATOM   2940 H HA   . THR A 1 196 ? -22.04363 -9.74826  11.50734  1.000 46.13900  ? 196 THR A HA   1 
ATOM   2941 H HB   . THR A 1 196 ? -24.51967 -9.64303  12.87996  1.000 50.31193  ? 196 THR A HB   1 
ATOM   2942 H HG1  . THR A 1 196 ? -23.51100 -7.94761  11.10370  1.000 45.08276  ? 196 THR A HG1  1 
ATOM   2943 H HG21 . THR A 1 196 ? -22.16881 -8.14000  13.32885  1.000 47.01487  ? 196 THR A HG21 1 
ATOM   2944 H HG22 . THR A 1 196 ? -23.56819 -7.65547  13.87609  1.000 47.01487  ? 196 THR A HG22 1 
ATOM   2945 H HG23 . THR A 1 196 ? -22.93945 -9.00500  14.40141  1.000 47.01487  ? 196 THR A HG23 1 
ATOM   2946 N N    . ASP A 1 197 ? -20.96771 -11.04834 13.26584  1.000 34.01849  ? 197 ASP A N    1 
ATOM   2947 C CA   . ASP A 1 197 ? -20.30545 -11.89014 14.26240  1.000 37.00695  ? 197 ASP A CA   1 
ATOM   2948 C C    . ASP A 1 197 ? -20.38686 -11.17607 15.60483  1.000 36.90719  ? 197 ASP A C    1 
ATOM   2949 O O    . ASP A 1 197 ? -19.48424 -10.43684 15.99641  1.000 36.75551  ? 197 ASP A O    1 
ATOM   2950 C CB   . ASP A 1 197 ? -18.86277 -12.16589 13.85752  1.000 39.85563  ? 197 ASP A CB   1 
ATOM   2951 C CG   . ASP A 1 197 ? -18.19380 -13.20703 14.73813  1.000 41.23762  ? 197 ASP A CG   1 
ATOM   2952 O OD1  . ASP A 1 197 ? -18.89647 -13.85308 15.55050  1.000 36.52422  ? 197 ASP A OD1  1 
ATOM   2953 O OD2  . ASP A 1 197 ? -16.96029 -13.37636 14.61588  1.000 42.98656  ? 197 ASP A OD2  1 
ATOM   2954 H H    . ASP A 1 197 ? -20.43865 -10.48815 12.88388  1.000 40.80923  ? 197 ASP A H    1 
ATOM   2955 H HA   . ASP A 1 197 ? -20.77160 -12.73787 14.33283  1.000 44.39538  ? 197 ASP A HA   1 
ATOM   2956 H HB2  . ASP A 1 197 ? -18.84763 -12.49143 12.94390  1.000 47.81381  ? 197 ASP A HB2  1 
ATOM   2957 H HB3  . ASP A 1 197 ? -18.35283 -11.34352 13.92518  1.000 47.81381  ? 197 ASP A HB3  1 
ATOM   2958 N N    . THR A 1 198 ? -21.48357 -11.40199 16.31890  1.000 33.52478  ? 198 THR A N    1 
ATOM   2959 C CA   . THR A 1 198 ? -21.69265 -10.75911 17.60520  1.000 34.96587  ? 198 THR A CA   1 
ATOM   2960 C C    . THR A 1 198 ? -20.96241 -11.51873 18.71145  1.000 34.26059  ? 198 THR A C    1 
ATOM   2961 O O    . THR A 1 198 ? -20.56503 -12.67666 18.55505  1.000 34.48616  ? 198 THR A O    1 
ATOM   2962 C CB   . THR A 1 198 ? -23.18650 -10.66475 17.91920  1.000 39.50096  ? 198 THR A CB   1 
ATOM   2963 O OG1  . THR A 1 198 ? -23.77263 -11.97002 17.86218  1.000 39.80075  ? 198 THR A OG1  1 
ATOM   2964 C CG2  . THR A 1 198 ? -23.88679 -9.75111  16.91399  1.000 39.77273  ? 198 THR A CG2  1 
ATOM   2965 H H    . THR A 1 198 ? -22.12232 -11.92514 16.07825  1.000 40.21679  ? 198 THR A H    1 
ATOM   2966 H HA   . THR A 1 198 ? -21.33593 -9.85748  17.57827  1.000 41.94609  ? 198 THR A HA   1 
ATOM   2967 H HB   . THR A 1 198 ? -23.30839 -10.29462 18.80748  1.000 47.38820  ? 198 THR A HB   1 
ATOM   2968 H HG1  . THR A 1 198 ? -23.83053 -12.22433 17.06370  1.000 47.74794  ? 198 THR A HG1  1 
ATOM   2969 H HG21 . THR A 1 198 ? -24.05240 -10.23192 16.08797  1.000 47.71433  ? 198 THR A HG21 1 
ATOM   2970 H HG22 . THR A 1 198 ? -24.73356 -9.44667  17.27621  1.000 47.71433  ? 198 THR A HG22 1 
ATOM   2971 H HG23 . THR A 1 198 ? -23.33049 -8.97975  16.72313  1.000 47.71433  ? 198 THR A HG23 1 
ATOM   2972 N N    . THR A 1 199 ? -20.78651 -10.84591 19.84328  1.000 32.35065  ? 199 THR A N    1 
ATOM   2973 C CA   . THR A 1 199 ? -19.97304 -11.35811 20.93786  1.000 29.39144  ? 199 THR A CA   1 
ATOM   2974 C C    . THR A 1 199 ? -20.84162 -12.07090 21.96661  1.000 31.16109  ? 199 THR A C    1 
ATOM   2975 O O    . THR A 1 199 ? -21.95866 -11.63646 22.26276  1.000 30.27887  ? 199 THR A O    1 
ATOM   2976 C CB   . THR A 1 199 ? -19.19427 -10.21932 21.59847  1.000 31.51932  ? 199 THR A CB   1 
ATOM   2977 O OG1  . THR A 1 199 ? -18.39737 -9.55705  20.60745  1.000 30.53143  ? 199 THR A OG1  1 
ATOM   2978 C CG2  . THR A 1 199 ? -18.28443 -10.74785 22.69257  1.000 32.50598  ? 199 THR A CG2  1 
ATOM   2979 H H    . THR A 1 199 ? -21.13503 -10.07610 20.00306  1.000 38.80783  ? 199 THR A H    1 
ATOM   2980 H HA   . THR A 1 199 ? -19.33965 -12.00727 20.59390  1.000 35.25678  ? 199 THR A HA   1 
ATOM   2981 H HB   . THR A 1 199 ? -19.81735 -9.59280  21.99867  1.000 37.81022  ? 199 THR A HB   1 
ATOM   2982 H HG1  . THR A 1 199 ? -17.65761 -9.33306  20.93635  1.000 36.62476  ? 199 THR A HG1  1 
ATOM   2983 H HG21 . THR A 1 199 ? -17.75989 -10.02284 23.06689  1.000 38.99423  ? 199 THR A HG21 1 
ATOM   2984 H HG22 . THR A 1 199 ? -18.81385 -11.15051 23.39860  1.000 38.99423  ? 199 THR A HG22 1 
ATOM   2985 H HG23 . THR A 1 199 ? -17.68300 -11.41675 22.32958  1.000 38.99423  ? 199 THR A HG23 1 
ATOM   2986 N N    . ILE A 1 200 ? -20.31411 -13.16923 22.50982  1.000 27.89763  ? 200 ILE A N    1 
ATOM   2987 C CA   . ILE A 1 200 ? -21.02168 -13.99183 23.48411  1.000 27.13919  ? 200 ILE A CA   1 
ATOM   2988 C C    . ILE A 1 200 ? -20.85677 -13.35456 24.85756  1.000 27.15388  ? 200 ILE A C    1 
ATOM   2989 O O    . ILE A 1 200 ? -19.91946 -13.67448 25.59675  1.000 26.31186  ? 200 ILE A O    1 
ATOM   2990 C CB   . ILE A 1 200 ? -20.50261 -15.44094 23.46941  1.000 24.74877  ? 200 ILE A CB   1 
ATOM   2991 C CG1  . ILE A 1 200 ? -20.56608 -16.01613 22.05378  1.000 30.16937  ? 200 ILE A CG1  1 
ATOM   2992 C CG2  . ILE A 1 200 ? -21.32054 -16.31126 24.41150  1.000 27.72725  ? 200 ILE A CG2  1 
ATOM   2993 C CD1  . ILE A 1 200 ? -19.53347 -17.10146 21.78929  1.000 28.90155  ? 200 ILE A CD1  1 
ATOM   2994 H H    . ILE A 1 200 ? -19.52791 -13.46407 22.32392  1.000 33.46420  ? 200 ILE A H    1 
ATOM   2995 H HA   . ILE A 1 200 ? -21.96668 -14.01729 23.26682  1.000 32.55407  ? 200 ILE A HA   1 
ATOM   2996 H HB   . ILE A 1 200 ? -19.57965 -15.43105 23.76764  1.000 29.68557  ? 200 ILE A HB   1 
ATOM   2997 H HG12 . ILE A 1 200 ? -21.44472 -16.40207 21.91259  1.000 36.19029  ? 200 ILE A HG12 1 
ATOM   2998 H HG13 . ILE A 1 200 ? -20.41248 -15.29953 21.41834  1.000 36.19029  ? 200 ILE A HG13 1 
ATOM   2999 H HG21 . ILE A 1 200 ? -22.26314 -16.18158 24.22285  1.000 33.25975  ? 200 ILE A HG21 1 
ATOM   3000 H HG22 . ILE A 1 200 ? -21.08002 -17.24052 24.27178  1.000 33.25975  ? 200 ILE A HG22 1 
ATOM   3001 H HG23 . ILE A 1 200 ? -21.12787 -16.05371 25.32662  1.000 33.25975  ? 200 ILE A HG23 1 
ATOM   3002 H HD11 . ILE A 1 200 ? -18.64562 -16.72113 21.87851  1.000 34.66890  ? 200 ILE A HD11 1 
ATOM   3003 H HD12 . ILE A 1 200 ? -19.65371 -17.81573 22.43449  1.000 34.66890  ? 200 ILE A HD12 1 
ATOM   3004 H HD13 . ILE A 1 200 ? -19.65800 -17.44347 20.89017  1.000 34.66890  ? 200 ILE A HD13 1 
ATOM   3005 N N    . THR A 1 201 ? -21.76834 -12.44157 25.19819  1.000 27.08269  ? 201 THR A N    1 
ATOM   3006 C CA   . THR A 1 201 ? -21.64315 -11.66391 26.42595  1.000 25.67052  ? 201 THR A CA   1 
ATOM   3007 C C    . THR A 1 201 ? -21.39977 -12.55565 27.63770  1.000 26.92506  ? 201 THR A C    1 
ATOM   3008 O O    . THR A 1 201 ? -20.45318 -12.33690 28.40288  1.000 26.73895  ? 201 THR A O    1 
ATOM   3009 C CB   . THR A 1 201 ? -22.90303 -10.81734 26.62553  1.000 30.05198  ? 201 THR A CB   1 
ATOM   3010 O OG1  . THR A 1 201 ? -23.22593 -10.15092 25.39923  1.000 28.42147  ? 201 THR A OG1  1 
ATOM   3011 C CG2  . THR A 1 201 ? -22.69238 -9.77727  27.72481  1.000 29.65825  ? 201 THR A CG2  1 
ATOM   3012 H H    . THR A 1 201 ? -22.46808 -12.25455 24.73451  1.000 32.48628  ? 201 THR A H    1 
ATOM   3013 H HA   . THR A 1 201 ? -20.88022 -11.07085 26.34158  1.000 30.79167  ? 201 THR A HA   1 
ATOM   3014 H HB   . THR A 1 201 ? -23.63823 -11.39174 26.89096  1.000 36.04942  ? 201 THR A HB   1 
ATOM   3015 H HG1  . THR A 1 201 ? -23.55339 -10.69812 24.85247  1.000 34.09281  ? 201 THR A HG1  1 
ATOM   3016 H HG21 . THR A 1 201 ? -22.40298 -10.21228 28.54206  1.000 35.57694  ? 201 THR A HG21 1 
ATOM   3017 H HG22 . THR A 1 201 ? -22.01565 -9.13827  27.45166  1.000 35.57694  ? 201 THR A HG22 1 
ATOM   3018 H HG23 . THR A 1 201 ? -23.52131 -9.30375  27.89676  1.000 35.57694  ? 201 THR A HG23 1 
ATOM   3019 N N    . VAL A 1 202 ? -22.25460 -13.56324 27.83767  1.000 26.41381  ? 202 VAL A N    1 
ATOM   3020 C CA   . VAL A 1 202 ? -22.13933 -14.40636 29.02287  1.000 27.38747  ? 202 VAL A CA   1 
ATOM   3021 C C    . VAL A 1 202 ? -20.74434 -15.01131 29.11665  1.000 27.47961  ? 202 VAL A C    1 
ATOM   3022 O O    . VAL A 1 202 ? -20.18768 -15.16295 30.21260  1.000 25.62291  ? 202 VAL A O    1 
ATOM   3023 C CB   . VAL A 1 202 ? -23.22691 -15.49928 29.01472  1.000 29.51812  ? 202 VAL A CB   1 
ATOM   3024 C CG1  . VAL A 1 202 ? -23.04611 -16.43463 27.82499  1.000 31.11877  ? 202 VAL A CG1  1 
ATOM   3025 C CG2  . VAL A 1 202 ? -23.20048 -16.27059 30.31983  1.000 29.02186  ? 202 VAL A CG2  1 
ATOM   3026 H H    . VAL A 1 202 ? -22.89925 -13.77430 27.30900  1.000 31.68362  ? 202 VAL A H    1 
ATOM   3027 H HA   . VAL A 1 202 ? -22.27798 -13.84990 29.80519  1.000 32.85201  ? 202 VAL A HA   1 
ATOM   3028 H HB   . VAL A 1 202 ? -24.09677 -15.07914 28.92683  1.000 35.40879  ? 202 VAL A HB   1 
ATOM   3029 H HG11 . VAL A 1 202 ? -22.95743 -15.90479 27.01734  1.000 37.32957  ? 202 VAL A HG11 1 
ATOM   3030 H HG12 . VAL A 1 202 ? -22.24683 -16.96723 27.96061  1.000 37.32957  ? 202 VAL A HG12 1 
ATOM   3031 H HG13 . VAL A 1 202 ? -23.82168 -17.01328 27.75749  1.000 37.32957  ? 202 VAL A HG13 1 
ATOM   3032 H HG21 . VAL A 1 202 ? -22.78692 -15.72052 31.00342  1.000 34.81328  ? 202 VAL A HG21 1 
ATOM   3033 H HG22 . VAL A 1 202 ? -24.11020 -16.48862 30.57628  1.000 34.81328  ? 202 VAL A HG22 1 
ATOM   3034 H HG23 . VAL A 1 202 ? -22.68781 -17.08456 30.19528  1.000 34.81328  ? 202 VAL A HG23 1 
ATOM   3035 N N    . ASN A 1 203 ? -20.15627 -15.36187 27.97176  1.000 25.94992  ? 203 ASN A N    1 
ATOM   3036 C CA   . ASN A 1 203 ? -18.82801 -15.96468 27.97781  1.000 27.85211  ? 203 ASN A CA   1 
ATOM   3037 C C    . ASN A 1 203 ? -17.76460 -14.95532 28.39387  1.000 26.26670  ? 203 ASN A C    1 
ATOM   3038 O O    . ASN A 1 203 ? -16.83301 -15.29728 29.13077  1.000 26.56499  ? 203 ASN A O    1 
ATOM   3039 C CB   . ASN A 1 203 ? -18.51299 -16.54227 26.59853  1.000 25.94993  ? 203 ASN A CB   1 
ATOM   3040 C CG   . ASN A 1 203 ? -19.24993 -17.84274 26.32535  1.000 27.91769  ? 203 ASN A CG   1 
ATOM   3041 O OD1  . ASN A 1 203 ? -20.09130 -18.27798 27.11305  1.000 25.42206  ? 203 ASN A OD1  1 
ATOM   3042 N ND2  . ASN A 1 203 ? -18.93980 -18.46673 25.19649  1.000 25.80262  ? 203 ASN A ND2  1 
ATOM   3043 H H    . ASN A 1 203 ? -20.50098 -15.26231 27.19019  1.000 31.12695  ? 203 ASN A H    1 
ATOM   3044 H HA   . ASN A 1 203 ? -18.81575 -16.69224 28.61923  1.000 33.40958  ? 203 ASN A HA   1 
ATOM   3045 H HB2  . ASN A 1 203 ? -18.77449 -15.90069 25.91964  1.000 31.12696  ? 203 ASN A HB2  1 
ATOM   3046 H HB3  . ASN A 1 203 ? -17.56098 -16.71852 26.53928  1.000 31.12696  ? 203 ASN A HB3  1 
ATOM   3047 H HD21 . ASN A 1 203 ? -19.32782 -19.20695 24.99373  1.000 30.95019  ? 203 ASN A HD21 1 
ATOM   3048 H HD22 . ASN A 1 203 ? -18.35072 -18.13103 24.66744  1.000 30.95019  ? 203 ASN A HD22 1 
ATOM   3049 N N    . VAL A 1 204 ? -17.87957 -13.70948 27.92766  1.000 26.69619  ? 204 VAL A N    1 
ATOM   3050 C CA   . VAL A 1 204 ? -16.94644 -12.67512 28.36404  1.000 26.58086  ? 204 VAL A CA   1 
ATOM   3051 C C    . VAL A 1 204 ? -17.01772 -12.51294 29.87765  1.000 27.78184  ? 204 VAL A C    1 
ATOM   3052 O O    . VAL A 1 204 ? -15.98871 -12.42422 30.56033  1.000 25.10609  ? 204 VAL A O    1 
ATOM   3053 C CB   . VAL A 1 204 ? -17.23508 -11.34709 27.63724  1.000 28.21106  ? 204 VAL A CB   1 
ATOM   3054 C CG1  . VAL A 1 204 ? -16.35708 -10.23753 28.19242  1.000 26.17497  ? 204 VAL A CG1  1 
ATOM   3055 C CG2  . VAL A 1 204 ? -17.01459 -11.49668 26.13618  1.000 28.39800  ? 204 VAL A CG2  1 
ATOM   3056 H H    . VAL A 1 204 ? -18.47746 -13.44420 27.36931  1.000 32.02247  ? 204 VAL A H    1 
ATOM   3057 H HA   . VAL A 1 204 ? -16.04628 -12.95024 28.12969  1.000 31.88408  ? 204 VAL A HA   1 
ATOM   3058 H HB   . VAL A 1 204 ? -18.16326 -11.10691 27.78452  1.000 33.84032  ? 204 VAL A HB   1 
ATOM   3059 H HG11 . VAL A 1 204 ? -15.48092 -10.60033 28.39644  1.000 31.39701  ? 204 VAL A HG11 1 
ATOM   3060 H HG12 . VAL A 1 204 ? -16.27778 -9.53525  27.52803  1.000 31.39701  ? 204 VAL A HG12 1 
ATOM   3061 H HG13 . VAL A 1 204 ? -16.76527 -9.88542  28.99883  1.000 31.39701  ? 204 VAL A HG13 1 
ATOM   3062 H HG21 . VAL A 1 204 ? -17.37448 -10.71711 25.68489  1.000 34.06465  ? 204 VAL A HG21 1 
ATOM   3063 H HG22 . VAL A 1 204 ? -16.06306 -11.56954 25.96247  1.000 34.06465  ? 204 VAL A HG22 1 
ATOM   3064 H HG23 . VAL A 1 204 ? -17.46922 -12.29634 25.82835  1.000 34.06465  ? 204 VAL A HG23 1 
ATOM   3065 N N    . LEU A 1 205 ? -18.23362 -12.49277 30.42856  1.000 26.61720  ? 205 LEU A N    1 
ATOM   3066 C CA   . LEU A 1 205 ? -18.38426 -12.34466 31.87242  1.000 25.51882  ? 205 LEU A CA   1 
ATOM   3067 C C    . LEU A 1 205 ? -17.75230 -13.51570 32.61076  1.000 27.75562  ? 205 LEU A C    1 
ATOM   3068 O O    . LEU A 1 205 ? -17.06926 -13.32403 33.62307  1.000 26.97759  ? 205 LEU A O    1 
ATOM   3069 C CB   . LEU A 1 205 ? -19.86523 -12.20086 32.22449  1.000 28.61378  ? 205 LEU A CB   1 
ATOM   3070 C CG   . LEU A 1 205 ? -20.49238 -10.90202 31.70194  1.000 26.68681  ? 205 LEU A CG   1 
ATOM   3071 C CD1  . LEU A 1 205 ? -21.99846 -10.87879 31.92208  1.000 28.99195  ? 205 LEU A CD1  1 
ATOM   3072 C CD2  . LEU A 1 205 ? -19.84067 -9.68616  32.35597  1.000 27.32713  ? 205 LEU A CD2  1 
ATOM   3073 H H    . LEU A 1 205 ? -18.97309 -12.56186 29.99497  1.000 31.92768  ? 205 LEU A H    1 
ATOM   3074 H HA   . LEU A 1 205 ? -17.93186 -11.53722 32.16271  1.000 30.60963  ? 205 LEU A HA   1 
ATOM   3075 H HB2  . LEU A 1 205 ? -20.35237 -12.94451 31.83646  1.000 34.32358  ? 205 LEU A HB2  1 
ATOM   3076 H HB3  . LEU A 1 205 ? -19.95932 -12.21021 33.18987  1.000 34.32358  ? 205 LEU A HB3  1 
ATOM   3077 H HG   . LEU A 1 205 ? -20.33647 -10.85653 30.74563  1.000 32.01121  ? 205 LEU A HG   1 
ATOM   3078 H HD11 . LEU A 1 205 ? -22.39617 -11.63619 31.46484  1.000 34.77739  ? 205 LEU A HD11 1 
ATOM   3079 H HD12 . LEU A 1 205 ? -22.17945 -10.93444 32.87342  1.000 34.77739  ? 205 LEU A HD12 1 
ATOM   3080 H HD13 . LEU A 1 205 ? -22.35709 -10.05128 31.56500  1.000 34.77739  ? 205 LEU A HD13 1 
ATOM   3081 H HD21 . LEU A 1 205 ? -19.82313 -9.81602  33.31707  1.000 32.77960  ? 205 LEU A HD21 1 
ATOM   3082 H HD22 . LEU A 1 205 ? -18.93618 -9.59277  32.01824  1.000 32.77960  ? 205 LEU A HD22 1 
ATOM   3083 H HD23 . LEU A 1 205 ? -20.35829 -8.89518  32.13845  1.000 32.77960  ? 205 LEU A HD23 1 
ATOM   3084 N N    . ALA A 1 206 ? -17.95367 -14.73767 32.11009  1.000 28.02230  ? 206 ALA A N    1 
ATOM   3085 C CA   . ALA A 1 206 ? -17.27994 -15.89513 32.68828  1.000 29.52183  ? 206 ALA A CA   1 
ATOM   3086 C C    . ALA A 1 206 ? -15.77119 -15.69509 32.69056  1.000 27.84709  ? 206 ALA A C    1 
ATOM   3087 O O    . ALA A 1 206 ? -15.09494 -15.95568 33.69286  1.000 28.64903  ? 206 ALA A O    1 
ATOM   3088 C CB   . ALA A 1 206 ? -17.64607 -17.15786 31.90658  1.000 28.48526  ? 206 ALA A CB   1 
ATOM   3089 H H    . ALA A 1 206 ? -18.46859 -14.91842 31.44542  1.000 33.61381  ? 206 ALA A H    1 
ATOM   3090 H HA   . ALA A 1 206 ? -17.57831 -16.00738 33.60439  1.000 35.41324  ? 206 ALA A HA   1 
ATOM   3091 H HB1  . ALA A 1 206 ? -17.27485 -17.92982 32.36175  1.000 34.16936  ? 206 ALA A HB1  1 
ATOM   3092 H HB2  . ALA A 1 206 ? -18.61215 -17.23289 31.86233  1.000 34.16936  ? 206 ALA A HB2  1 
ATOM   3093 H HB3  . ALA A 1 206 ? -17.27799 -17.09301 31.01147  1.000 34.16936  ? 206 ALA A HB3  1 
ATOM   3094 N N    . TRP A 1 207 ? -15.22914 -15.23018 31.56402  1.000 28.22052  ? 207 TRP A N    1 
ATOM   3095 C CA   . TRP A 1 207 ? -13.79054 -15.01864 31.44516  1.000 30.98273  ? 207 TRP A CA   1 
ATOM   3096 C C    . TRP A 1 207 ? -13.31099 -13.93240 32.40045  1.000 29.25672  ? 207 TRP A C    1 
ATOM   3097 O O    . TRP A 1 207 ? -12.22106 -14.04166 32.97169  1.000 29.20824  ? 207 TRP A O    1 
ATOM   3098 C CB   . TRP A 1 207 ? -13.45915 -14.67746 29.99035  1.000 30.11574  ? 207 TRP A CB   1 
ATOM   3099 C CG   . TRP A 1 207 ? -12.03098 -14.30186 29.69613  1.000 32.72211  ? 207 TRP A CG   1 
ATOM   3100 C CD1  . TRP A 1 207 ? -10.95752 -15.14026 29.60278  1.000 31.55276  ? 207 TRP A CD1  1 
ATOM   3101 C CD2  . TRP A 1 207 ? -11.53676 -12.98698 29.41528  1.000 32.70073  ? 207 TRP A CD2  1 
ATOM   3102 N NE1  . TRP A 1 207 ? -9.82194  -14.42424 29.29727  1.000 32.45986  ? 207 TRP A NE1  1 
ATOM   3103 C CE2  . TRP A 1 207 ? -10.15250 -13.10114 29.17611  1.000 32.85462  ? 207 TRP A CE2  1 
ATOM   3104 C CE3  . TRP A 1 207 ? -12.12952 -11.72423 29.34920  1.000 34.01630  ? 207 TRP A CE3  1 
ATOM   3105 C CZ2  . TRP A 1 207 ? -9.35457  -11.99945 28.88109  1.000 35.02014  ? 207 TRP A CZ2  1 
ATOM   3106 C CZ3  . TRP A 1 207 ? -11.33461 -10.63361 29.05489  1.000 34.82697  ? 207 TRP A CZ3  1 
ATOM   3107 C CH2  . TRP A 1 207 ? -9.96406  -10.77871 28.82277  1.000 34.32058  ? 207 TRP A CH2  1 
ATOM   3108 H H    . TRP A 1 207 ? -15.67286 -15.02993 30.85507  1.000 33.85167  ? 207 TRP A H    1 
ATOM   3109 H HA   . TRP A 1 207 ? -13.31540 -15.83074 31.68104  1.000 37.16632  ? 207 TRP A HA   1 
ATOM   3110 H HB2  . TRP A 1 207 ? -13.66745 -15.45176 29.44449  1.000 36.12594  ? 207 TRP A HB2  1 
ATOM   3111 H HB3  . TRP A 1 207 ? -14.01121 -13.92563 29.72410  1.000 36.12594  ? 207 TRP A HB3  1 
ATOM   3112 H HD1  . TRP A 1 207 ? -10.98882 -16.06134 29.72747  1.000 37.85036  ? 207 TRP A HD1  1 
ATOM   3113 H HE1  . TRP A 1 207 ? -9.03387  -14.75411 29.19867  1.000 38.93888  ? 207 TRP A HE1  1 
ATOM   3114 H HE3  . TRP A 1 207 ? -13.04119 -11.61971 29.50032  1.000 40.80661  ? 207 TRP A HE3  1 
ATOM   3115 H HZ2  . TRP A 1 207 ? -8.44159  -12.09113 28.72955  1.000 42.01121  ? 207 TRP A HZ2  1 
ATOM   3116 H HZ3  . TRP A 1 207 ? -11.71826 -9.78760  29.01040  1.000 41.77941  ? 207 TRP A HZ3  1 
ATOM   3117 H HH2  . TRP A 1 207 ? -9.45510  -10.02617 28.62390  1.000 41.17174  ? 207 TRP A HH2  1 
ATOM   3118 N N    . LEU A 1 208 ? -14.11178 -12.87826 32.59084  1.000 31.06877  ? 208 LEU A N    1 
ATOM   3119 C CA   . LEU A 1 208 ? -13.77851 -11.86916 33.59496  1.000 31.04228  ? 208 LEU A CA   1 
ATOM   3120 C C    . LEU A 1 208 ? -13.76814 -12.47282 34.99444  1.000 31.38307  ? 208 LEU A C    1 
ATOM   3121 O O    . LEU A 1 208 ? -12.95508 -12.08688 35.84285  1.000 30.54821  ? 208 LEU A O    1 
ATOM   3122 C CB   . LEU A 1 208 ? -14.76798 -10.70510 33.52046  1.000 31.10583  ? 208 LEU A CB   1 
ATOM   3123 C CG   . LEU A 1 208 ? -14.68055 -9.83350  32.26710  1.000 31.51777  ? 208 LEU A CG   1 
ATOM   3124 C CD1  . LEU A 1 208 ? -15.69840 -8.69952  32.31183  1.000 33.75274  ? 208 LEU A CD1  1 
ATOM   3125 C CD2  . LEU A 1 208 ? -13.27366 -9.27615  32.08559  1.000 33.12257  ? 208 LEU A CD2  1 
ATOM   3126 H H    . LEU A 1 208 ? -14.84015 -12.72802 32.15899  1.000 37.26957  ? 208 LEU A H    1 
ATOM   3127 H HA   . LEU A 1 208 ? -12.89265 -11.52110 33.40786  1.000 37.23778  ? 208 LEU A HA   1 
ATOM   3128 H HB2  . LEU A 1 208 ? -15.66654 -11.06873 33.55584  1.000 37.31404  ? 208 LEU A HB2  1 
ATOM   3129 H HB3  . LEU A 1 208 ? -14.61366 -10.12717 34.28406  1.000 37.31404  ? 208 LEU A HB3  1 
ATOM   3130 H HG   . LEU A 1 208 ? -14.88620 -10.38890 31.49890  1.000 37.80837  ? 208 LEU A HG   1 
ATOM   3131 H HD11 . LEU A 1 208 ? -15.82890 -8.35670  31.41386  1.000 40.49033  ? 208 LEU A HD11 1 
ATOM   3132 H HD12 . LEU A 1 208 ? -16.53661 -9.04111  32.66056  1.000 40.49033  ? 208 LEU A HD12 1 
ATOM   3133 H HD13 . LEU A 1 208 ? -15.36224 -7.99601  32.88887  1.000 40.49033  ? 208 LEU A HD13 1 
ATOM   3134 H HD21 . LEU A 1 208 ? -12.95761 -8.93334  32.93618  1.000 39.73413  ? 208 LEU A HD21 1 
ATOM   3135 H HD22 . LEU A 1 208 ? -12.68968 -9.98690  31.77785  1.000 39.73413  ? 208 LEU A HD22 1 
ATOM   3136 H HD23 . LEU A 1 208 ? -13.29914 -8.56177  31.42992  1.000 39.73413  ? 208 LEU A HD23 1 
ATOM   3137 N N    . TYR A 1 209 ? -14.66738 -13.42310 35.25847  1.000 30.60956  ? 209 TYR A N    1 
ATOM   3138 C CA   . TYR A 1 209 ? -14.62989 -14.12528 36.53685  1.000 28.76507  ? 209 TYR A CA   1 
ATOM   3139 C C    . TYR A 1 209 ? -13.38234 -14.99368 36.64809  1.000 32.02930  ? 209 TYR A C    1 
ATOM   3140 O O    . TYR A 1 209 ? -12.79705 -15.11359 37.72952  1.000 30.82667  ? 209 TYR A O    1 
ATOM   3141 C CB   . TYR A 1 209 ? -15.89006 -14.96911 36.71180  1.000 30.22910  ? 209 TYR A CB   1 
ATOM   3142 C CG   . TYR A 1 209 ? -17.06791 -14.19216 37.25608  1.000 29.73802  ? 209 TYR A CG   1 
ATOM   3143 C CD1  . TYR A 1 209 ? -17.04765 -13.68611 38.54686  1.000 31.79040  ? 209 TYR A CD1  1 
ATOM   3144 C CD2  . TYR A 1 209 ? -18.19884 -13.97235 36.48528  1.000 29.67135  ? 209 TYR A CD2  1 
ATOM   3145 C CE1  . TYR A 1 209 ? -18.11400 -12.97867 39.05248  1.000 31.74883  ? 209 TYR A CE1  1 
ATOM   3146 C CE2  . TYR A 1 209 ? -19.27416 -13.26618 36.98480  1.000 30.76031  ? 209 TYR A CE2  1 
ATOM   3147 C CZ   . TYR A 1 209 ? -19.22609 -12.77385 38.26941  1.000 29.63647  ? 209 TYR A CZ   1 
ATOM   3148 O OH   . TYR A 1 209 ? -20.29072 -12.06821 38.77535  1.000 30.75084  ? 209 TYR A OH   1 
ATOM   3149 H H    . TYR A 1 209 ? -15.29440 -13.67328 34.72569  1.000 36.71852  ? 209 TYR A H    1 
ATOM   3150 H HA   . TYR A 1 209 ? -14.60847 -13.47143 37.25304  1.000 34.50513  ? 209 TYR A HA   1 
ATOM   3151 H HB2  . TYR A 1 209 ? -16.14625 -15.33079 35.84898  1.000 36.26196  ? 209 TYR A HB2  1 
ATOM   3152 H HB3  . TYR A 1 209 ? -15.69923 -15.69115 37.33078  1.000 36.26196  ? 209 TYR A HB3  1 
ATOM   3153 H HD1  . TYR A 1 209 ? -16.29942 -13.82749 39.08078  1.000 38.13553  ? 209 TYR A HD1  1 
ATOM   3154 H HD2  . TYR A 1 209 ? -18.23349 -14.30599 35.61789  1.000 35.59267  ? 209 TYR A HD2  1 
ATOM   3155 H HE1  . TYR A 1 209 ? -18.08300 -12.64103 39.91847  1.000 38.08564  ? 209 TYR A HE1  1 
ATOM   3156 H HE2  . TYR A 1 209 ? -20.02647 -13.12383 36.45691  1.000 36.89942  ? 209 TYR A HE2  1 
ATOM   3157 H HH   . TYR A 1 209 ? -21.00577 -12.33744 38.42632  1.000 36.88805  ? 209 TYR A HH   1 
ATOM   3158 N N    . ALA A 1 210 ? -12.95590 -15.60183 35.53867  1.000 32.27493  ? 210 ALA A N    1 
ATOM   3159 C CA   . ALA A 1 210 ? -11.72653 -16.38727 35.55828  1.000 33.01333  ? 210 ALA A CA   1 
ATOM   3160 C C    . ALA A 1 210 ? -10.52954 -15.51711 35.91233  1.000 31.41122  ? 210 ALA A C    1 
ATOM   3161 O O    . ALA A 1 210 ? -9.65650  -15.93243 36.68362  1.000 32.42455  ? 210 ALA A O    1 
ATOM   3162 C CB   . ALA A 1 210 ? -11.51002 -17.05956 34.20329  1.000 31.86084  ? 210 ALA A CB   1 
ATOM   3163 H H    . ALA A 1 210 ? -13.35381 -15.57483 34.77674  1.000 38.71696  ? 210 ALA A H    1 
ATOM   3164 H HA   . ALA A 1 210 ? -11.81007 -17.08215 36.22989  1.000 39.60305  ? 210 ALA A HA   1 
ATOM   3165 H HB1  . ALA A 1 210 ? -12.34424 -17.46017 33.91263  1.000 38.22005  ? 210 ALA A HB1  1 
ATOM   3166 H HB2  . ALA A 1 210 ? -11.22269 -16.39136 33.56154  1.000 38.22005  ? 210 ALA A HB2  1 
ATOM   3167 H HB3  . ALA A 1 210 ? -10.82888 -17.74398 34.29558  1.000 38.22005  ? 210 ALA A HB3  1 
ATOM   3168 N N    . ALA A 1 211 ? -10.46938 -14.30699 35.35265  1.000 31.16956  ? 211 ALA A N    1 
ATOM   3169 C CA   . ALA A 1 211 ? -9.36200  -13.40393 35.64930  1.000 31.34029  ? 211 ALA A CA   1 
ATOM   3170 C C    . ALA A 1 211 ? -9.30990  -13.07845 37.13543  1.000 33.59927  ? 211 ALA A C    1 
ATOM   3171 O O    . ALA A 1 211 ? -8.24302  -13.11755 37.75738  1.000 33.44804  ? 211 ALA A O    1 
ATOM   3172 C CB   . ALA A 1 211 ? -9.49696  -12.12693 34.82083  1.000 33.96328  ? 211 ALA A CB   1 
ATOM   3173 H H    . ALA A 1 211 ? -11.05103 -13.98981 34.80431  1.000 37.39052  ? 211 ALA A H    1 
ATOM   3174 H HA   . ALA A 1 211 ? -8.52804  -13.83500 35.40517  1.000 37.59540  ? 211 ALA A HA   1 
ATOM   3175 H HB1  . ALA A 1 211 ? -10.31025 -11.66649 35.08054  1.000 40.74298  ? 211 ALA A HB1  1 
ATOM   3176 H HB2  . ALA A 1 211 ? -8.72803  -11.55961 34.98752  1.000 40.74298  ? 211 ALA A HB2  1 
ATOM   3177 H HB3  . ALA A 1 211 ? -9.53628  -12.36301 33.88082  1.000 40.74298  ? 211 ALA A HB3  1 
ATOM   3178 N N    . VAL A 1 212 ? -10.46199 -12.76217 37.72490  1.000 33.44809  ? 212 VAL A N    1 
ATOM   3179 C CA   . VAL A 1 212 ? -10.50172 -12.44510 39.14834  1.000 33.45515  ? 212 VAL A CA   1 
ATOM   3180 C C    . VAL A 1 212 ? -10.03198 -13.63756 39.97014  1.000 34.50302  ? 212 VAL A C    1 
ATOM   3181 O O    . VAL A 1 212 ? -9.26805  -13.48535 40.93091  1.000 35.58816  ? 212 VAL A O    1 
ATOM   3182 C CB   . VAL A 1 212 ? -11.92023 -11.99742 39.54748  1.000 36.77331  ? 212 VAL A CB   1 
ATOM   3183 C CG1  . VAL A 1 212 ? -12.03617 -11.85889 41.05613  1.000 36.96874  ? 212 VAL A CG1  1 
ATOM   3184 C CG2  . VAL A 1 212 ? -12.27487 -10.68714 38.84814  1.000 37.80905  ? 212 VAL A CG2  1 
ATOM   3185 H H    . VAL A 1 212 ? -11.22403 -12.72465 37.32804  1.000 40.12475  ? 212 VAL A H    1 
ATOM   3186 H HA   . VAL A 1 212 ? -9.89430  -11.70932 39.32316  1.000 40.13323  ? 212 VAL A HA   1 
ATOM   3187 H HB   . VAL A 1 212 ? -12.55680 -12.67288 39.26562  1.000 44.11501  ? 212 VAL A HB   1 
ATOM   3188 H HG11 . VAL A 1 212 ? -11.14737 -11.77003 41.43433  1.000 44.34953  ? 212 VAL A HG11 1 
ATOM   3189 H HG12 . VAL A 1 212 ? -12.56327 -11.07087 41.26132  1.000 44.34953  ? 212 VAL A HG12 1 
ATOM   3190 H HG13 . VAL A 1 212 ? -12.47017 -12.64939 41.41342  1.000 44.34953  ? 212 VAL A HG13 1 
ATOM   3191 H HG21 . VAL A 1 212 ? -13.13049 -10.37337 39.18036  1.000 45.35790  ? 212 VAL A HG21 1 
ATOM   3192 H HG22 . VAL A 1 212 ? -11.58575 -10.03136 39.03780  1.000 45.35790  ? 212 VAL A HG22 1 
ATOM   3193 H HG23 . VAL A 1 212 ? -12.32841 -10.84373 37.89236  1.000 45.35790  ? 212 VAL A HG23 1 
ATOM   3194 N N    . ILE A 1 213 ? -10.47334 -14.84436 39.60369  1.000 33.77903  ? 213 ILE A N    1 
ATOM   3195 C CA   . ILE A 1 213 ? -10.03716 -16.03930 40.32054  1.000 34.06998  ? 213 ILE A CA   1 
ATOM   3196 C C    . ILE A 1 213 ? -8.51880  -16.14902 40.29537  1.000 36.00726  ? 213 ILE A C    1 
ATOM   3197 O O    . ILE A 1 213 ? -7.89641  -16.57679 41.27509  1.000 37.66834  ? 213 ILE A O    1 
ATOM   3198 C CB   . ILE A 1 213 ? -10.70225 -17.29342 39.72484  1.000 33.22849  ? 213 ILE A CB   1 
ATOM   3199 C CG1  . ILE A 1 213 ? -12.19697 -17.30519 40.05424  1.000 36.63200  ? 213 ILE A CG1  1 
ATOM   3200 C CG2  . ILE A 1 213 ? -10.01279 -18.55049 40.24252  1.000 36.69785  ? 213 ILE A CG2  1 
ATOM   3201 C CD1  . ILE A 1 213 ? -13.00087 -18.29018 39.23391  1.000 37.41364  ? 213 ILE A CD1  1 
ATOM   3202 H H    . ILE A 1 213 ? -11.01669 -14.99386 38.95406  1.000 40.52188  ? 213 ILE A H    1 
ATOM   3203 H HA   . ILE A 1 213 ? -10.31756 -15.96140 41.24586  1.000 40.87102  ? 213 ILE A HA   1 
ATOM   3204 H HB   . ILE A 1 213 ? -10.60719 -17.27220 38.75975  1.000 39.86124  ? 213 ILE A HB   1 
ATOM   3205 H HG12 . ILE A 1 213 ? -12.30747 -17.54033 40.98880  1.000 43.94545  ? 213 ILE A HG12 1 
ATOM   3206 H HG13 . ILE A 1 213 ? -12.55847 -16.42021 39.88983  1.000 43.94545  ? 213 ILE A HG13 1 
ATOM   3207 H HG21 . ILE A 1 213 ? -9.21476  -18.71276 39.71553  1.000 44.02447  ? 213 ILE A HG21 1 
ATOM   3208 H HG22 . ILE A 1 213 ? -9.77345  -18.41887 41.17327  1.000 44.02447  ? 213 ILE A HG22 1 
ATOM   3209 H HG23 . ILE A 1 213 ? -10.62164 -19.30114 40.16051  1.000 44.02447  ? 213 ILE A HG23 1 
ATOM   3210 H HD11 . ILE A 1 213 ? -12.95961 -18.03119 38.30003  1.000 44.88341  ? 213 ILE A HD11 1 
ATOM   3211 H HD12 . ILE A 1 213 ? -12.62508 -19.17710 39.34812  1.000 44.88341  ? 213 ILE A HD12 1 
ATOM   3212 H HD13 . ILE A 1 213 ? -13.92126 -18.27898 39.53993  1.000 44.88341  ? 213 ILE A HD13 1 
ATOM   3213 N N    . ASN A 1 214 ? -7.89877  -15.76003 39.18035  1.000 35.37211  ? 214 ASN A N    1 
ATOM   3214 C CA   . ASN A 1 214 ? -6.45521  -15.84400 39.01275  1.000 37.25451  ? 214 ASN A CA   1 
ATOM   3215 C C    . ASN A 1 214 ? -5.73748  -14.55202 39.38924  1.000 37.75903  ? 214 ASN A C    1 
ATOM   3216 O O    . ASN A 1 214 ? -4.61677  -14.31931 38.92113  1.000 40.52932  ? 214 ASN A O    1 
ATOM   3217 C CB   . ASN A 1 214 ? -6.11999  -16.23495 37.57209  1.000 36.78772  ? 214 ASN A CB   1 
ATOM   3218 C CG   . ASN A 1 214 ? -6.41863  -17.69305 37.28501  1.000 36.66293  ? 214 ASN A CG   1 
ATOM   3219 O OD1  . ASN A 1 214 ? -5.51653  -18.52940 37.27070  1.000 38.23826  ? 214 ASN A OD1  1 
ATOM   3220 N ND2  . ASN A 1 214 ? -7.69239  -18.00846 37.06883  1.000 35.41189  ? 214 ASN A ND2  1 
ATOM   3221 H H    . ASN A 1 214 ? -8.30527  -15.43764 38.49448  1.000 42.43358  ? 214 ASN A H    1 
ATOM   3222 H HA   . ASN A 1 214 ? -6.12107  -16.54118 39.59858  1.000 44.69246  ? 214 ASN A HA   1 
ATOM   3223 H HB2  . ASN A 1 214 ? -6.64867  -15.69375 36.96505  1.000 44.13231  ? 214 ASN A HB2  1 
ATOM   3224 H HB3  . ASN A 1 214 ? -5.17498  -16.08394 37.41384  1.000 44.13231  ? 214 ASN A HB3  1 
ATOM   3225 H HD21 . ASN A 1 214 ? -7.91125  -18.82320 36.90179  1.000 42.48131  ? 214 ASN A HD21 1 
ATOM   3226 H HD22 . ASN A 1 214 ? -8.29721  -17.39769 37.09607  1.000 42.48131  ? 214 ASN A HD22 1 
ATOM   3227 N N    . GLY A 1 215 ? -6.35945  -13.70851 40.21105  1.000 39.18104  ? 215 GLY A N    1 
ATOM   3228 C CA   . GLY A 1 215 ? -5.68621  -12.56569 40.79561  1.000 40.14407  ? 215 GLY A CA   1 
ATOM   3229 C C    . GLY A 1 215 ? -5.52975  -11.35763 39.90159  1.000 43.06932  ? 215 GLY A C    1 
ATOM   3230 O O    . GLY A 1 215 ? -4.79827  -10.43112 40.26880  1.000 46.20961  ? 215 GLY A O    1 
ATOM   3231 H H    . GLY A 1 215 ? -7.18353  -13.78225 40.44568  1.000 47.00429  ? 215 GLY A H    1 
ATOM   3232 H HA2  . GLY A 1 215 ? -6.18489  -12.28485 41.57878  1.000 48.15993  ? 215 GLY A HA2  1 
ATOM   3233 H HA3  . GLY A 1 215 ? -4.79747  -12.84159 41.06931  1.000 48.15993  ? 215 GLY A HA3  1 
ATOM   3234 N N    . ASP A 1 216 ? -6.18723  -11.32618 38.74756  1.000 41.23964  ? 216 ASP A N    1 
ATOM   3235 C CA   . ASP A 1 216 ? -6.13102  -10.17717 37.84425  1.000 42.73839  ? 216 ASP A CA   1 
ATOM   3236 C C    . ASP A 1 216 ? -7.43139  -9.39501  38.01841  1.000 44.38442  ? 216 ASP A C    1 
ATOM   3237 O O    . ASP A 1 216 ? -8.45389  -9.72619  37.41216  1.000 43.48799  ? 216 ASP A O    1 
ATOM   3238 C CB   . ASP A 1 216 ? -5.91981  -10.63630 36.40655  1.000 40.75014  ? 216 ASP A CB   1 
ATOM   3239 C CG   . ASP A 1 216 ? -5.54632  -9.49825  35.48123  1.000 46.94090  ? 216 ASP A CG   1 
ATOM   3240 O OD1  . ASP A 1 216 ? -6.14207  -8.40693  35.60999  1.000 48.52434  ? 216 ASP A OD1  1 
ATOM   3241 O OD2  . ASP A 1 216 ? -4.65370  -9.69579  34.62664  1.000 46.76648  ? 216 ASP A OD2  1 
ATOM   3242 H H    . ASP A 1 216 ? -6.68139  -11.96836 38.45944  1.000 49.47462  ? 216 ASP A H    1 
ATOM   3243 H HA   . ASP A 1 216 ? -5.39097  -9.59762  38.08370  1.000 51.27311  ? 216 ASP A HA   1 
ATOM   3244 H HB2  . ASP A 1 216 ? -5.20272  -11.28914 36.38471  1.000 48.88721  ? 216 ASP A HB2  1 
ATOM   3245 H HB3  . ASP A 1 216 ? -6.74089  -11.03424 36.07734  1.000 48.88721  ? 216 ASP A HB3  1 
ATOM   3246 N N    . ARG A 1 217 ? -7.38707  -8.35033  38.85313  1.000 45.24658  ? 217 ARG A N    1 
ATOM   3247 C CA   . ARG A 1 217 ? -8.58302  -7.63594  39.28703  1.000 44.26196  ? 217 ARG A CA   1 
ATOM   3248 C C    . ARG A 1 217 ? -8.58131  -6.15370  38.92628  1.000 41.60928  ? 217 ARG A C    1 
ATOM   3249 O O    . ARG A 1 217 ? -9.48201  -5.42604  39.36214  1.000 39.28371  ? 217 ARG A O    1 
ATOM   3250 C CB   . ARG A 1 217 ? -8.75352  -7.76490  40.80657  1.000 51.34776  ? 217 ARG A CB   1 
ATOM   3251 C CG   . ARG A 1 217 ? -9.05761  -9.16163  41.31303  1.000 56.06565  ? 217 ARG A CG   1 
ATOM   3252 C CD   . ARG A 1 217 ? -9.34193  -9.14791  42.81458  1.000 73.56178  ? 217 ARG A CD   1 
ATOM   3253 N NE   . ARG A 1 217 ? -8.28368  -8.48490  43.57102  1.000 77.99525  ? 217 ARG A NE   1 
ATOM   3254 C CZ   . ARG A 1 217 ? -8.31442  -7.21890  43.97155  1.000 82.12271  ? 217 ARG A CZ   1 
ATOM   3255 N NH1  . ARG A 1 217 ? -9.35517  -6.43760  43.72778  1.000 78.83683  ? 217 ARG A NH1  1 
ATOM   3256 N NH2  . ARG A 1 217 ? -7.27263  -6.72307  44.63377  1.000 74.33302  ? 217 ARG A NH2  1 
ATOM   3257 H H    . ARG A 1 217 ? -6.65987  -8.03383  39.18572  1.000 54.28294  ? 217 ARG A H    1 
ATOM   3258 H HA   . ARG A 1 217 ? -9.33874  -8.04700  38.83892  1.000 53.10140  ? 217 ARG A HA   1 
ATOM   3259 H HB2  . ARG A 1 217 ? -7.93058  -7.47655  41.23143  1.000 61.60436  ? 217 ARG A HB2  1 
ATOM   3260 H HB3  . ARG A 1 217 ? -9.48684  -7.19230  41.08093  1.000 61.60436  ? 217 ARG A HB3  1 
ATOM   3261 H HG2  . ARG A 1 217 ? -9.83935  -9.50859  40.85544  1.000 67.26582  ? 217 ARG A HG2  1 
ATOM   3262 H HG3  . ARG A 1 217 ? -8.29469  -9.73807  41.15002  1.000 67.26582  ? 217 ARG A HG3  1 
ATOM   3263 H HD2  . ARG A 1 217 ? -10.17210 -8.67324  42.97704  1.000 88.26118  ? 217 ARG A HD2  1 
ATOM   3264 H HD3  . ARG A 1 217 ? -9.41415  -10.06123 43.13324  1.000 88.26118  ? 217 ARG A HD3  1 
ATOM   3265 H HE   . ARG A 1 217 ? -7.58818  -8.94895  43.77238  1.000 93.58134  ? 217 ARG A HE   1 
ATOM   3266 H HH11 . ARG A 1 217 ? -10.03418 -6.74684  43.30008  1.000 94.59124  ? 217 ARG A HH11 1 
ATOM   3267 H HH12 . ARG A 1 217 ? -9.35218  -5.62088  43.99713  1.000 94.59124  ? 217 ARG A HH12 1 
ATOM   3268 H HH21 . ARG A 1 217 ? -6.59071  -7.22084  44.79750  1.000 89.18667  ? 217 ARG A HH21 1 
ATOM   3269 H HH22 . ARG A 1 217 ? -7.28107  -5.90476  44.89814  1.000 89.18667  ? 217 ARG A HH22 1 
ATOM   3270 N N    . TRP A 1 218 ? -7.60594  -5.67747  38.14995  1.000 36.17002  ? 218 TRP A N    1 
ATOM   3271 C CA   . TRP A 1 218 ? -7.45907  -4.23686  37.96615  1.000 36.67246  ? 218 TRP A CA   1 
ATOM   3272 C C    . TRP A 1 218 ? -8.70137  -3.58302  37.36988  1.000 37.13100  ? 218 TRP A C    1 
ATOM   3273 O O    . TRP A 1 218 ? -8.89199  -2.37447  37.54412  1.000 34.72779  ? 218 TRP A O    1 
ATOM   3274 C CB   . TRP A 1 218 ? -6.24376  -3.92820  37.08455  1.000 35.80734  ? 218 TRP A CB   1 
ATOM   3275 C CG   . TRP A 1 218 ? -6.32723  -4.43449  35.66713  1.000 35.14903  ? 218 TRP A CG   1 
ATOM   3276 C CD1  . TRP A 1 218 ? -5.77615  -5.58158  35.17824  1.000 35.17018  ? 218 TRP A CD1  1 
ATOM   3277 C CD2  . TRP A 1 218 ? -6.98311  -3.80163  34.55739  1.000 32.78379  ? 218 TRP A CD2  1 
ATOM   3278 N NE1  . TRP A 1 218 ? -6.05110  -5.70710  33.83809  1.000 33.20263  ? 218 TRP A NE1  1 
ATOM   3279 C CE2  . TRP A 1 218 ? -6.79128  -4.62922  33.43267  1.000 31.01521  ? 218 TRP A CE2  1 
ATOM   3280 C CE3  . TRP A 1 218 ? -7.71454  -2.61985  34.40638  1.000 32.04019  ? 218 TRP A CE3  1 
ATOM   3281 C CZ2  . TRP A 1 218 ? -7.30396  -4.31371  32.17689  1.000 31.34873  ? 218 TRP A CZ2  1 
ATOM   3282 C CZ3  . TRP A 1 218 ? -8.22424  -2.30914  33.15619  1.000 32.29879  ? 218 TRP A CZ3  1 
ATOM   3283 C CH2  . TRP A 1 218 ? -8.01537  -3.15365  32.05889  1.000 32.50894  ? 218 TRP A CH2  1 
ATOM   3284 H H    . TRP A 1 218 ? -7.02998  -6.15753  37.72874  1.000 43.39107  ? 218 TRP A H    1 
ATOM   3285 H HA   . TRP A 1 218 ? -7.30743  -3.84289  38.83947  1.000 43.99400  ? 218 TRP A HA   1 
ATOM   3286 H HB2  . TRP A 1 218 ? -6.13434  -2.96536  37.04137  1.000 42.95585  ? 218 TRP A HB2  1 
ATOM   3287 H HB3  . TRP A 1 218 ? -5.46129  -4.33315  37.49031  1.000 42.95585  ? 218 TRP A HB3  1 
ATOM   3288 H HD1  . TRP A 1 218 ? -5.28476  -6.19141  35.67979  1.000 42.19126  ? 218 TRP A HD1  1 
ATOM   3289 H HE1  . TRP A 1 218 ? -5.79901  -6.35759  33.33519  1.000 39.83020  ? 218 TRP A HE1  1 
ATOM   3290 H HE3  . TRP A 1 218 ? -7.85610  -2.05373  35.13051  1.000 38.43527  ? 218 TRP A HE3  1 
ATOM   3291 H HZ2  . TRP A 1 218 ? -7.16707  -4.87204  31.44585  1.000 37.60552  ? 218 TRP A HZ2  1 
ATOM   3292 H HZ3  . TRP A 1 218 ? -8.71350  -1.52627  33.04378  1.000 38.74559  ? 218 TRP A HZ3  1 
ATOM   3293 H HH2  . TRP A 1 218 ? -8.36894  -2.91943  31.23123  1.000 38.99777  ? 218 TRP A HH2  1 
ATOM   3294 N N    . PHE A 1 219 ? -9.55508  -4.34593  36.69234  1.000 34.63891  ? 219 PHE A N    1 
ATOM   3295 C CA   . PHE A 1 219 ? -10.68977 -3.79130  35.96354  1.000 35.30165  ? 219 PHE A CA   1 
ATOM   3296 C C    . PHE A 1 219 ? -11.96419 -3.71130  36.79487  1.000 33.92795  ? 219 PHE A C    1 
ATOM   3297 O O    . PHE A 1 219 ? -12.97524 -3.20787  36.29830  1.000 31.47010  ? 219 PHE A O    1 
ATOM   3298 C CB   . PHE A 1 219 ? -10.95857 -4.62510  34.70509  1.000 33.12008  ? 219 PHE A CB   1 
ATOM   3299 C CG   . PHE A 1 219 ? -11.13315 -6.09014  34.97991  1.000 32.75892  ? 219 PHE A CG   1 
ATOM   3300 C CD1  . PHE A 1 219 ? -10.04058 -6.94373  34.97934  1.000 33.87208  ? 219 PHE A CD1  1 
ATOM   3301 C CD2  . PHE A 1 219 ? -12.38304 -6.61220  35.25478  1.000 36.02701  ? 219 PHE A CD2  1 
ATOM   3302 C CE1  . PHE A 1 219 ? -10.19293 -8.28869  35.23898  1.000 36.32206  ? 219 PHE A CE1  1 
ATOM   3303 C CE2  . PHE A 1 219 ? -12.54226 -7.96093  35.51847  1.000 37.42882  ? 219 PHE A CE2  1 
ATOM   3304 C CZ   . PHE A 1 219 ? -11.44650 -8.79907  35.51023  1.000 36.85597  ? 219 PHE A CZ   1 
ATOM   3305 H H    . PHE A 1 219 ? -9.49635  -5.20229  36.63945  1.000 41.55374  ? 219 PHE A H    1 
ATOM   3306 H HA   . PHE A 1 219 ? -10.46250 -2.88855  35.69098  1.000 42.34903  ? 219 PHE A HA   1 
ATOM   3307 H HB2  . PHE A 1 219 ? -11.77144 -4.30325  34.28489  1.000 39.73114  ? 219 PHE A HB2  1 
ATOM   3308 H HB3  . PHE A 1 219 ? -10.20893 -4.52455  34.09777  1.000 39.73114  ? 219 PHE A HB3  1 
ATOM   3309 H HD1  . PHE A 1 219 ? -9.19332  -6.60409  34.80132  1.000 40.63355  ? 219 PHE A HD1  1 
ATOM   3310 H HD2  . PHE A 1 219 ? -13.12463 -6.05106  35.26255  1.000 43.21945  ? 219 PHE A HD2  1 
ATOM   3311 H HE1  . PHE A 1 219 ? -9.45250  -8.85137  35.23145  1.000 43.57351  ? 219 PHE A HE1  1 
ATOM   3312 H HE2  . PHE A 1 219 ? -13.38774 -8.30249  35.70124  1.000 44.90163  ? 219 PHE A HE2  1 
ATOM   3313 H HZ   . PHE A 1 219 ? -11.55216 -9.70597  35.68704  1.000 44.21421  ? 219 PHE A HZ   1 
ATOM   3314 N N    . LEU A 1 220 ? -11.95002 -4.19615  38.03321  1.000 34.93592  ? 220 LEU A N    1 
ATOM   3315 C CA   . LEU A 1 220 ? -13.12126 -4.07744  38.89071  1.000 34.91864  ? 220 LEU A CA   1 
ATOM   3316 C C    . LEU A 1 220 ? -13.27234 -2.63650  39.36534  1.000 35.24652  ? 220 LEU A C    1 
ATOM   3317 O O    . LEU A 1 220 ? -12.32881 -2.04757  39.90025  1.000 35.86710  ? 220 LEU A O    1 
ATOM   3318 C CB   . LEU A 1 220 ? -12.99951 -5.01872  40.08618  1.000 34.85137  ? 220 LEU A CB   1 
ATOM   3319 C CG   . LEU A 1 220 ? -12.73977 -6.49111  39.76233  1.000 36.31798  ? 220 LEU A CG   1 
ATOM   3320 C CD1  . LEU A 1 220 ? -12.45405 -7.27155  41.03523  1.000 48.87720  ? 220 LEU A CD1  1 
ATOM   3321 C CD2  . LEU A 1 220 ? -13.91904 -7.09797  39.01876  1.000 37.65151  ? 220 LEU A CD2  1 
ATOM   3322 H H    . LEU A 1 220 ? -11.28007 -4.59460  38.39653  1.000 41.91015  ? 220 LEU A H    1 
ATOM   3323 H HA   . LEU A 1 220 ? -13.91588 -4.32454  38.39228  1.000 41.88942  ? 220 LEU A HA   1 
ATOM   3324 H HB2  . LEU A 1 220 ? -12.26254 -4.71241  40.63749  1.000 41.80869  ? 220 LEU A HB2  1 
ATOM   3325 H HB3  . LEU A 1 220 ? -13.82860 -4.97780  40.58802  1.000 41.80869  ? 220 LEU A HB3  1 
ATOM   3326 H HG   . LEU A 1 220 ? -11.96177 -6.55235  39.18625  1.000 43.56862  ? 220 LEU A HG   1 
ATOM   3327 H HD11 . LEU A 1 220 ? -11.75341 -6.82043  41.53171  1.000 58.63969  ? 220 LEU A HD11 1 
ATOM   3328 H HD12 . LEU A 1 220 ? -13.26320 -7.31305  41.56856  1.000 58.63969  ? 220 LEU A HD12 1 
ATOM   3329 H HD13 . LEU A 1 220 ? -12.16747 -8.16756  40.79869  1.000 58.63969  ? 220 LEU A HD13 1 
ATOM   3330 H HD21 . LEU A 1 220 ? -13.71144 -8.01877  38.79527  1.000 45.16885  ? 220 LEU A HD21 1 
ATOM   3331 H HD22 . LEU A 1 220 ? -14.70296 -7.06468  39.58907  1.000 45.16885  ? 220 LEU A HD22 1 
ATOM   3332 H HD23 . LEU A 1 220 ? -14.07751 -6.58861  38.20861  1.000 45.16885  ? 220 LEU A HD23 1 
ATOM   3333 N N    . ASN A 1 221 ? -14.45867 -2.07065  39.17053  1.000 34.64089  ? 221 ASN A N    1 
ATOM   3334 C CA   . ASN A 1 221 ? -14.75191 -0.69861  39.55320  1.000 35.77718  ? 221 ASN A CA   1 
ATOM   3335 C C    . ASN A 1 221 ? -15.74468 -0.68410  40.71411  1.000 38.75993  ? 221 ASN A C    1 
ATOM   3336 O O    . ASN A 1 221 ? -16.16186 -1.72803  41.22074  1.000 36.88265  ? 221 ASN A O    1 
ATOM   3337 C CB   . ASN A 1 221 ? -15.27816 0.09465   38.35219  1.000 37.31744  ? 221 ASN A CB   1 
ATOM   3338 C CG   . ASN A 1 221 ? -16.58249 -0.45902  37.79983  1.000 37.45320  ? 221 ASN A CG   1 
ATOM   3339 O OD1  . ASN A 1 221 ? -17.39129 -1.03181  38.52754  1.000 36.15817  ? 221 ASN A OD1  1 
ATOM   3340 N ND2  . ASN A 1 221 ? -16.79043 -0.28564  36.49898  1.000 38.84783  ? 221 ASN A ND2  1 
ATOM   3341 H H    . ASN A 1 221 ? -15.12584 -2.47480  38.80840  1.000 41.55612  ? 221 ASN A H    1 
ATOM   3342 H HA   . ASN A 1 221 ? -13.93378 -0.27380  39.85500  1.000 42.91966  ? 221 ASN A HA   1 
ATOM   3343 H HB2  . ASN A 1 221 ? -15.43458 1.01235   38.62469  1.000 44.76798  ? 221 ASN A HB2  1 
ATOM   3344 H HB3  . ASN A 1 221 ? -14.61749 0.06733   37.64249  1.000 44.76798  ? 221 ASN A HB3  1 
ATOM   3345 H HD21 . ASN A 1 221 ? -17.51245 -0.57977  36.13598  1.000 46.60444  ? 221 ASN A HD21 1 
ATOM   3346 H HD22 . ASN A 1 221 ? -16.20300 0.12072   36.02003  1.000 46.60444  ? 221 ASN A HD22 1 
ATOM   3347 N N    . ARG A 1 222 ? -16.11848 0.52364   41.13284  1.000 41.73533  ? 222 ARG A N    1 
ATOM   3348 C CA   . ARG A 1 222 ? -16.99731 0.74030   42.27433  1.000 46.38897  ? 222 ARG A CA   1 
ATOM   3349 C C    . ARG A 1 222 ? -18.47274 0.74141   41.89990  1.000 40.64785  ? 222 ARG A C    1 
ATOM   3350 O O    . ARG A 1 222 ? -19.31056 1.02921   42.75947  1.000 40.43654  ? 222 ARG A O    1 
ATOM   3351 C CB   . ARG A 1 222 ? -16.64899 2.07224   42.95485  1.000 51.96940  ? 222 ARG A CB   1 
ATOM   3352 C CG   . ARG A 1 222 ? -15.24740 2.10262   43.55887  1.000 54.15444  ? 222 ARG A CG   1 
ATOM   3353 C CD   . ARG A 1 222 ? -14.73565 3.51051   43.88847  1.000 64.48381  ? 222 ARG A CD   1 
ATOM   3354 N NE   . ARG A 1 222 ? -15.23119 4.55765   42.99710  1.000 68.06664  ? 222 ARG A NE   1 
ATOM   3355 C CZ   . ARG A 1 222 ? -16.20781 5.41441   43.28770  1.000 69.67249  ? 222 ARG A CZ   1 
ATOM   3356 N NH1  . ARG A 1 222 ? -16.85275 5.37410   44.44853  1.000 63.87765  ? 222 ARG A NH1  1 
ATOM   3357 N NH2  . ARG A 1 222 ? -16.54133 6.34389   42.39246  1.000 64.24047  ? 222 ARG A NH2  1 
ATOM   3358 H H    . ARG A 1 222 ? -15.86652 1.25552   40.75805  1.000 50.06945  ? 222 ARG A H    1 
ATOM   3359 H HA   . ARG A 1 222 ? -16.85181 0.02074   42.90832  1.000 55.65381  ? 222 ARG A HA   1 
ATOM   3360 H HB2  . ARG A 1 222 ? -16.70396 2.78285   42.29689  1.000 62.35033  ? 222 ARG A HB2  1 
ATOM   3361 H HB3  . ARG A 1 222 ? -17.28395 2.23277   43.67037  1.000 62.35033  ? 222 ARG A HB3  1 
ATOM   3362 H HG2  . ARG A 1 222 ? -15.25298 1.59191   44.38352  1.000 64.97237  ? 222 ARG A HG2  1 
ATOM   3363 H HG3  . ARG A 1 222 ? -14.62774 1.70563   42.92696  1.000 64.97237  ? 222 ARG A HG3  1 
ATOM   3364 H HD2  . ARG A 1 222 ? -15.01300 3.73793   44.78972  1.000 77.36762  ? 222 ARG A HD2  1 
ATOM   3365 H HD3  . ARG A 1 222 ? -13.76744 3.50998   43.82949  1.000 77.36762  ? 222 ARG A HD3  1 
ATOM   3366 H HE   . ARG A 1 222 ? -14.86241 4.62570   42.22316  1.000 81.66702  ? 222 ARG A HE   1 
ATOM   3367 H HH11 . ARG A 1 222 ? -16.64284 4.78291   45.03676  1.000 76.64022  ? 222 ARG A HH11 1 
ATOM   3368 H HH12 . ARG A 1 222 ? -17.48015 5.93920   44.61171  1.000 76.64022  ? 222 ARG A HH12 1 
ATOM   3369 H HH21 . ARG A 1 222 ? -16.12741 6.38400   41.63969  1.000 77.07561  ? 222 ARG A HH21 1 
ATOM   3370 H HH22 . ARG A 1 222 ? -17.17043 6.90349   42.56762  1.000 77.07561  ? 222 ARG A HH22 1 
ATOM   3371 N N    . PHE A 1 223 ? -18.81083 0.41718   40.65549  1.000 38.80260  ? 223 PHE A N    1 
ATOM   3372 C CA   . PHE A 1 223 ? -20.16033 0.59692   40.14412  1.000 36.12207  ? 223 PHE A CA   1 
ATOM   3373 C C    . PHE A 1 223 ? -20.91012 -0.73026  40.06940  1.000 33.87737  ? 223 PHE A C    1 
ATOM   3374 O O    . PHE A 1 223 ? -20.33764 -1.81859  40.16771  1.000 33.19130  ? 223 PHE A O    1 
ATOM   3375 C CB   . PHE A 1 223 ? -20.13422 1.23819   38.74966  1.000 38.19667  ? 223 PHE A CB   1 
ATOM   3376 C CG   . PHE A 1 223 ? -19.17428 2.38738   38.61580  1.000 39.57136  ? 223 PHE A CG   1 
ATOM   3377 C CD1  . PHE A 1 223 ? -18.87879 3.20148   39.69561  1.000 44.37023  ? 223 PHE A CD1  1 
ATOM   3378 C CD2  . PHE A 1 223 ? -18.56922 2.65349   37.40042  1.000 42.32895  ? 223 PHE A CD2  1 
ATOM   3379 C CE1  . PHE A 1 223 ? -17.99412 4.25362   39.56541  1.000 48.49708  ? 223 PHE A CE1  1 
ATOM   3380 C CE2  . PHE A 1 223 ? -17.68551 3.70568   37.26364  1.000 44.32599  ? 223 PHE A CE2  1 
ATOM   3381 C CZ   . PHE A 1 223 ? -17.39739 4.50670   38.34699  1.000 45.06560  ? 223 PHE A CZ   1 
ATOM   3382 H H    . PHE A 1 223 ? -18.26426 0.08558   40.08025  1.000 46.55017  ? 223 PHE A H    1 
ATOM   3383 H HA   . PHE A 1 223 ? -20.63217 1.18339   40.75593  1.000 43.33353  ? 223 PHE A HA   1 
ATOM   3384 H HB2  . PHE A 1 223 ? -19.87623 0.56295   38.10283  1.000 45.82304  ? 223 PHE A HB2  1 
ATOM   3385 H HB3  . PHE A 1 223 ? -21.02192 1.57149   38.54519  1.000 45.82304  ? 223 PHE A HB3  1 
ATOM   3386 H HD1  . PHE A 1 223 ? -19.28070 3.03793   40.51817  1.000 53.23132  ? 223 PHE A HD1  1 
ATOM   3387 H HD2  . PHE A 1 223 ? -18.76026 2.11644   36.66558  1.000 50.78178  ? 223 PHE A HD2  1 
ATOM   3388 H HE1  . PHE A 1 223 ? -17.80039 4.79173   40.29877  1.000 58.18354  ? 223 PHE A HE1  1 
ATOM   3389 H HE2  . PHE A 1 223 ? -17.28524 3.87347   36.44113  1.000 53.17824  ? 223 PHE A HE2  1 
ATOM   3390 H HZ   . PHE A 1 223 ? -16.80249 5.21591   38.25746  1.000 54.06576  ? 223 PHE A HZ   1 
ATOM   3391 N N    . THR A 1 224 ? -22.22265 -0.61399  39.90085  1.000 31.71260  ? 224 THR A N    1 
ATOM   3392 C CA   . THR A 1 224 ? -23.09065 -1.69696  39.47115  1.000 30.24388  ? 224 THR A CA   1 
ATOM   3393 C C    . THR A 1 224 ? -23.99213 -1.14748  38.36998  1.000 29.81248  ? 224 THR A C    1 
ATOM   3394 O O    . THR A 1 224 ? -23.92312 0.03406   38.02003  1.000 26.83945  ? 224 THR A O    1 
ATOM   3395 C CB   . THR A 1 224 ? -23.91728 -2.26397  40.63020  1.000 31.17060  ? 224 THR A CB   1 
ATOM   3396 O OG1  . THR A 1 224 ? -24.44352 -3.54696  40.26178  1.000 29.46594  ? 224 THR A OG1  1 
ATOM   3397 C CG2  . THR A 1 224 ? -25.07126 -1.32953  40.97745  1.000 34.05559  ? 224 THR A CG2  1 
ATOM   3398 H H    . THR A 1 224 ? -22.65130 0.11912   40.03652  1.000 38.04217  ? 224 THR A H    1 
ATOM   3399 H HA   . THR A 1 224 ? -22.55622 -2.42688  39.12114  1.000 36.27970  ? 224 THR A HA   1 
ATOM   3400 H HB   . THR A 1 224 ? -23.35216 -2.35559  41.41323  1.000 37.39176  ? 224 THR A HB   1 
ATOM   3401 H HG1  . THR A 1 224 ? -23.82349 -4.11261  40.22710  1.000 35.34618  ? 224 THR A HG1  1 
ATOM   3402 H HG21 . THR A 1 224 ? -25.79071 -1.43822  40.33598  1.000 40.85376  ? 224 THR A HG21 1 
ATOM   3403 H HG22 . THR A 1 224 ? -25.40710 -1.53251  41.86453  1.000 40.85376  ? 224 THR A HG22 1 
ATOM   3404 H HG23 . THR A 1 224 ? -24.76915 -0.40797  40.95847  1.000 40.85376  ? 224 THR A HG23 1 
ATOM   3405 N N    . THR A 1 225 ? -24.84627 -2.00619  37.82191  1.000 28.80060  ? 225 THR A N    1 
ATOM   3406 C CA   . THR A 1 225 ? -25.75667 -1.60351  36.75952  1.000 32.70622  ? 225 THR A CA   1 
ATOM   3407 C C    . THR A 1 225 ? -27.01018 -2.46616  36.84712  1.000 32.55955  ? 225 THR A C    1 
ATOM   3408 O O    . THR A 1 225 ? -27.16745 -3.27799  37.76441  1.000 29.74885  ? 225 THR A O    1 
ATOM   3409 C CB   . THR A 1 225 ? -25.08307 -1.71906  35.38368  1.000 34.13938  ? 225 THR A CB   1 
ATOM   3410 O OG1  . THR A 1 225 ? -25.90042 -1.09005  34.38743  1.000 32.75584  ? 225 THR A OG1  1 
ATOM   3411 C CG2  . THR A 1 225 ? -24.87037 -3.17906  35.00577  1.000 33.04694  ? 225 THR A CG2  1 
ATOM   3412 H H    . THR A 1 225 ? -24.91684 -2.83222  38.05063  1.000 34.54776  ? 225 THR A H    1 
ATOM   3413 H HA   . THR A 1 225 ? -26.01359 -0.67784  36.89378  1.000 39.23451  ? 225 THR A HA   1 
ATOM   3414 H HB   . THR A 1 225 ? -24.21782 -1.28187  35.41706  1.000 40.95430  ? 225 THR A HB   1 
ATOM   3415 H HG1  . THR A 1 225 ? -25.78709 -0.25794  34.40629  1.000 39.29405  ? 225 THR A HG1  1 
ATOM   3416 H HG21 . THR A 1 225 ? -25.72025 -3.59238  34.78719  1.000 39.64338  ? 225 THR A HG21 1 
ATOM   3417 H HG22 . THR A 1 225 ? -24.28330 -3.24037  34.23604  1.000 39.64338  ? 225 THR A HG22 1 
ATOM   3418 H HG23 . THR A 1 225 ? -24.46858 -3.65850  35.74712  1.000 39.64338  ? 225 THR A HG23 1 
ATOM   3419 N N    . THR A 1 226 ? -27.91107 -2.27287  35.88936  1.000 32.69276  ? 226 THR A N    1 
ATOM   3420 C CA   . THR A 1 226 ? -29.07392 -3.12695  35.70659  1.000 34.05175  ? 226 THR A CA   1 
ATOM   3421 C C    . THR A 1 226 ? -28.94191 -3.87893  34.38926  1.000 35.10128  ? 226 THR A C    1 
ATOM   3422 O O    . THR A 1 226 ? -28.21381 -3.46813  33.48340  1.000 29.42395  ? 226 THR A O    1 
ATOM   3423 C CB   . THR A 1 226 ? -30.37442 -2.31690  35.70730  1.000 34.43160  ? 226 THR A CB   1 
ATOM   3424 O OG1  . THR A 1 226 ? -30.50411 -1.61368  34.46588  1.000 37.16315  ? 226 THR A OG1  1 
ATOM   3425 C CG2  . THR A 1 226 ? -30.38431 -1.31949  36.85733  1.000 35.89122  ? 226 THR A CG2  1 
ATOM   3426 H H    . THR A 1 226 ? -27.86671 -1.63293  35.31655  1.000 39.21836  ? 226 THR A H    1 
ATOM   3427 H HA   . THR A 1 226 ? -29.12386 -3.76369  36.43664  1.000 40.84915  ? 226 THR A HA   1 
ATOM   3428 H HB   . THR A 1 226 ? -31.12821 -2.91721  35.81832  1.000 41.30497  ? 226 THR A HB   1 
ATOM   3429 H HG1  . THR A 1 226 ? -30.16237 -0.84916  34.53170  1.000 44.58282  ? 226 THR A HG1  1 
ATOM   3430 H HG21 . THR A 1 226 ? -29.78515 -0.58207  36.66209  1.000 43.05651  ? 226 THR A HG21 1 
ATOM   3431 H HG22 . THR A 1 226 ? -31.28035 -0.97126  36.98677  1.000 43.05651  ? 226 THR A HG22 1 
ATOM   3432 H HG23 . THR A 1 226 ? -30.09391 -1.75304  37.67501  1.000 43.05651  ? 226 THR A HG23 1 
ATOM   3433 N N    . LEU A 1 227 ? -29.66046 -4.99757  34.29392  1.000 37.41346  ? 227 LEU A N    1 
ATOM   3434 C CA   . LEU A 1 227 ? -29.62005 -5.78862  33.06930  1.000 36.69660  ? 227 LEU A CA   1 
ATOM   3435 C C    . LEU A 1 227 ? -30.08023 -4.96233  31.87587  1.000 36.93999  ? 227 LEU A C    1 
ATOM   3436 O O    . LEU A 1 227 ? -29.48680 -5.03583  30.79394  1.000 35.70534  ? 227 LEU A O    1 
ATOM   3437 C CB   . LEU A 1 227 ? -30.48458 -7.03875  33.23665  1.000 38.31329  ? 227 LEU A CB   1 
ATOM   3438 C CG   . LEU A 1 227 ? -30.16084 -8.30492  32.43977  1.000 40.18725  ? 227 LEU A CG   1 
ATOM   3439 C CD1  . LEU A 1 227 ? -28.67405 -8.46603  32.16530  1.000 36.94845  ? 227 LEU A CD1  1 
ATOM   3440 C CD2  . LEU A 1 227 ? -30.68618 -9.50828  33.21607  1.000 37.99014  ? 227 LEU A CD2  1 
ATOM   3441 H H    . LEU A 1 227 ? -30.16876 -5.31315  34.91169  1.000 44.88320  ? 227 LEU A H    1 
ATOM   3442 H HA   . LEU A 1 227 ? -28.70950 -6.07631  32.89887  1.000 44.02297  ? 227 LEU A HA   1 
ATOM   3443 H HB2  . LEU A 1 227 ? -30.44513 -7.29136  34.17234  1.000 45.96299  ? 227 LEU A HB2  1 
ATOM   3444 H HB3  . LEU A 1 227 ? -31.39206 -6.79383  32.99710  1.000 45.96299  ? 227 LEU A HB3  1 
ATOM   3445 H HG   . LEU A 1 227 ? -30.58779 -8.24466  31.57088  1.000 48.21175  ? 227 LEU A HG   1 
ATOM   3446 H HD11 . LEU A 1 227 ? -28.38973 -7.77289  31.54916  1.000 44.32518  ? 227 LEU A HD11 1 
ATOM   3447 H HD12 . LEU A 1 227 ? -28.18810 -8.38546  33.00093  1.000 44.32518  ? 227 LEU A HD12 1 
ATOM   3448 H HD13 . LEU A 1 227 ? -28.51790 -9.34011  31.77480  1.000 44.32518  ? 227 LEU A HD13 1 
ATOM   3449 H HD21 . LEU A 1 227 ? -31.62749 -9.37392  33.40786  1.000 45.57522  ? 227 LEU A HD21 1 
ATOM   3450 H HD22 . LEU A 1 227 ? -30.56892 -10.30684 32.67807  1.000 45.57522  ? 227 LEU A HD22 1 
ATOM   3451 H HD23 . LEU A 1 227 ? -30.18841 -9.59149  34.04445  1.000 45.57522  ? 227 LEU A HD23 1 
ATOM   3452 N N    . ASN A 1 228 ? -31.13051 -4.15851  32.05643  1.000 38.53400  ? 228 ASN A N    1 
ATOM   3453 C CA   . ASN A 1 228 ? -31.63301 -3.33797  30.95921  1.000 40.04366  ? 228 ASN A CA   1 
ATOM   3454 C C    . ASN A 1 228 ? -30.62394 -2.26085  30.56941  1.000 38.40045  ? 228 ASN A C    1 
ATOM   3455 O O    . ASN A 1 228 ? -30.33016 -2.07268  29.38317  1.000 36.40710  ? 228 ASN A O    1 
ATOM   3456 C CB   . ASN A 1 228 ? -32.97708 -2.71556  31.34869  1.000 45.93750  ? 228 ASN A CB   1 
ATOM   3457 C CG   . ASN A 1 228 ? -34.09968 -3.74276  31.42300  1.000 52.36416  ? 228 ASN A CG   1 
ATOM   3458 O OD1  . ASN A 1 228 ? -34.04030 -4.79377  30.78279  1.000 49.88014  ? 228 ASN A OD1  1 
ATOM   3459 N ND2  . ASN A 1 228 ? -35.13099 -3.43846  32.20380  1.000 58.36456  ? 228 ASN A ND2  1 
ATOM   3460 H H    . ASN A 1 228 ? -31.56287 -4.07220  32.79482  1.000 46.22785  ? 228 ASN A H    1 
ATOM   3461 H HA   . ASN A 1 228 ? -31.77749 -3.90208  30.18345  1.000 48.03944  ? 228 ASN A HA   1 
ATOM   3462 H HB2  . ASN A 1 228 ? -32.89236 -2.29953  32.22084  1.000 55.11205  ? 228 ASN A HB2  1 
ATOM   3463 H HB3  . ASN A 1 228 ? -33.22175 -2.05056  30.68626  1.000 55.11205  ? 228 ASN A HB3  1 
ATOM   3464 H HD21 . ASN A 1 228 ? -35.78979 -3.98612  32.27890  1.000 70.02451  ? 228 ASN A HD21 1 
ATOM   3465 H HD22 . ASN A 1 228 ? -35.13962 -2.69385  32.63402  1.000 70.02451  ? 228 ASN A HD22 1 
ATOM   3466 N N    . ASP A 1 229 ? -30.07454 -1.54507  31.55508  1.000 37.86185  ? 229 ASP A N    1 
ATOM   3467 C CA   . ASP A 1 229 ? -29.09702 -0.50646  31.24272  1.000 39.39788  ? 229 ASP A CA   1 
ATOM   3468 C C    . ASP A 1 229 ? -27.85084 -1.10115  30.59822  1.000 38.94752  ? 229 ASP A C    1 
ATOM   3469 O O    . ASP A 1 229 ? -27.30049 -0.53032  29.64874  1.000 38.00364  ? 229 ASP A O    1 
ATOM   3470 C CB   . ASP A 1 229 ? -28.72246 0.27678   32.50360  1.000 39.32600  ? 229 ASP A CB   1 
ATOM   3471 C CG   . ASP A 1 229 ? -29.67243 1.42960   32.77928  1.000 44.94782  ? 229 ASP A CG   1 
ATOM   3472 O OD1  . ASP A 1 229 ? -30.79754 1.42478   32.23547  1.000 48.61752  ? 229 ASP A OD1  1 
ATOM   3473 O OD2  . ASP A 1 229 ? -29.28593 2.35108   33.52967  1.000 48.85470  ? 229 ASP A OD2  1 
ATOM   3474 H H    . ASP A 1 229 ? -30.24769 -1.64017  32.39208  1.000 45.42127  ? 229 ASP A H    1 
ATOM   3475 H HA   . ASP A 1 229 ? -29.49944 0.11524   30.61627  1.000 47.26450  ? 229 ASP A HA   1 
ATOM   3476 H HB2  . ASP A 1 229 ? -28.74652 -0.32148  33.26676  1.000 47.17824  ? 229 ASP A HB2  1 
ATOM   3477 H HB3  . ASP A 1 229 ? -27.83020 0.64179   32.39619  1.000 47.17824  ? 229 ASP A HB3  1 
ATOM   3478 N N    . PHE A 1 230 ? -27.39223 -2.25148  31.09394  1.000 36.88083  ? 230 PHE A N    1 
ATOM   3479 C CA   . PHE A 1 230 ? -26.20374 -2.86783  30.51757  1.000 37.36663  ? 230 PHE A CA   1 
ATOM   3480 C C    . PHE A 1 230 ? -26.42699 -3.22261  29.05239  1.000 34.85715  ? 230 PHE A C    1 
ATOM   3481 O O    . PHE A 1 230 ? -25.59475 -2.91571  28.19206  1.000 36.01782  ? 230 PHE A O    1 
ATOM   3482 C CB   . PHE A 1 230 ? -25.80856 -4.11629  31.30452  1.000 34.01633  ? 230 PHE A CB   1 
ATOM   3483 C CG   . PHE A 1 230 ? -24.74064 -4.92586  30.62835  1.000 37.20451  ? 230 PHE A CG   1 
ATOM   3484 C CD1  . PHE A 1 230 ? -23.40392 -4.58726  30.76801  1.000 36.29666  ? 230 PHE A CD1  1 
ATOM   3485 C CD2  . PHE A 1 230 ? -25.07288 -6.00578  29.82973  1.000 34.24079  ? 230 PHE A CD2  1 
ATOM   3486 C CE1  . PHE A 1 230 ? -22.41870 -5.31926  30.13810  1.000 32.76984  ? 230 PHE A CE1  1 
ATOM   3487 C CE2  . PHE A 1 230 ? -24.09099 -6.74217  29.19731  1.000 34.95410  ? 230 PHE A CE2  1 
ATOM   3488 C CZ   . PHE A 1 230 ? -22.76291 -6.39795  29.35032  1.000 32.31194  ? 230 PHE A CZ   1 
ATOM   3489 H H    . PHE A 1 230 ? -27.74428 -2.68391  31.74867  1.000 44.24404  ? 230 PHE A H    1 
ATOM   3490 H HA   . PHE A 1 230 ? -25.47410 -2.23142  30.57675  1.000 44.82700  ? 230 PHE A HA   1 
ATOM   3491 H HB2  . PHE A 1 230 ? -25.47361 -3.84681  32.17406  1.000 40.80664  ? 230 PHE A HB2  1 
ATOM   3492 H HB3  . PHE A 1 230 ? -26.58977 -4.68142  31.41050  1.000 40.80664  ? 230 PHE A HB3  1 
ATOM   3493 H HD1  . PHE A 1 230 ? -23.16802 -3.85697  31.29329  1.000 43.54303  ? 230 PHE A HD1  1 
ATOM   3494 H HD2  . PHE A 1 230 ? -25.96645 -6.23795  29.71780  1.000 41.07599  ? 230 PHE A HD2  1 
ATOM   3495 H HE1  . PHE A 1 230 ? -21.52472 -5.08602  30.24435  1.000 39.31085  ? 230 PHE A HE1  1 
ATOM   3496 H HE2  . PHE A 1 230 ? -24.32442 -7.47037  28.66804  1.000 41.93197  ? 230 PHE A HE2  1 
ATOM   3497 H HZ   . PHE A 1 230 ? -22.10136 -6.89253  28.92296  1.000 38.76137  ? 230 PHE A HZ   1 
ATOM   3498 N N    . ASN A 1 231 ? -27.54830 -3.88190  28.75077  1.000 34.28070  ? 231 ASN A N    1 
ATOM   3499 C CA   . ASN A 1 231 ? -27.80006 -4.31618  27.38121  1.000 35.20083  ? 231 ASN A CA   1 
ATOM   3500 C C    . ASN A 1 231 ? -27.89611 -3.13861  26.41772  1.000 36.77278  ? 231 ASN A C    1 
ATOM   3501 O O    . ASN A 1 231 ? -27.49078 -3.25778  25.25556  1.000 36.77625  ? 231 ASN A O    1 
ATOM   3502 C CB   . ASN A 1 231 ? -29.07319 -5.16319  27.32903  1.000 33.92122  ? 231 ASN A CB   1 
ATOM   3503 C CG   . ASN A 1 231 ? -28.85248 -6.57428  27.84232  1.000 31.80271  ? 231 ASN A CG   1 
ATOM   3504 O OD1  . ASN A 1 231 ? -27.73159 -7.08324  27.82342  1.000 34.20386  ? 231 ASN A OD1  1 
ATOM   3505 N ND2  . ASN A 1 231 ? -29.92162 -7.21576  28.30003  1.000 35.11112  ? 231 ASN A ND2  1 
ATOM   3506 H H    . ASN A 1 231 ? -28.16710 -4.08569  29.31215  1.000 41.12388  ? 231 ASN A H    1 
ATOM   3507 H HA   . ASN A 1 231 ? -27.05927 -4.87002  27.08898  1.000 42.22805  ? 231 ASN A HA   1 
ATOM   3508 H HB2  . ASN A 1 231 ? -29.75460 -4.74583  27.87893  1.000 40.69251  ? 231 ASN A HB2  1 
ATOM   3509 H HB3  . ASN A 1 231 ? -29.37811 -5.22125  26.41004  1.000 40.69251  ? 231 ASN A HB3  1 
ATOM   3510 H HD21 . ASN A 1 231 ? -29.84569 -8.01770  28.60123  1.000 42.12040  ? 231 ASN A HD21 1 
ATOM   3511 H HD22 . ASN A 1 231 ? -30.68982 -6.82917  28.29519  1.000 42.12040  ? 231 ASN A HD22 1 
ATOM   3512 N N    . LEU A 1 232 ? -28.41900 -1.99551  26.87163  1.000 37.34403  ? 232 LEU A N    1 
ATOM   3513 C CA   . LEU A 1 232 ? -28.45930 -0.82100  26.00519  1.000 36.99510  ? 232 LEU A CA   1 
ATOM   3514 C C    . LEU A 1 232 ? -27.06138 -0.43840  25.53541  1.000 37.56123  ? 232 LEU A C    1 
ATOM   3515 O O    . LEU A 1 232 ? -26.87279 -0.04175  24.37960  1.000 39.39085  ? 232 LEU A O    1 
ATOM   3516 C CB   . LEU A 1 232 ? -29.11383 0.35641   26.72985  1.000 40.74095  ? 232 LEU A CB   1 
ATOM   3517 C CG   . LEU A 1 232 ? -30.64353 0.42150   26.76208  1.000 49.38003  ? 232 LEU A CG   1 
ATOM   3518 C CD1  . LEU A 1 232 ? -31.09152 1.74391   27.36882  1.000 59.34263  ? 232 LEU A CD1  1 
ATOM   3519 C CD2  . LEU A 1 232 ? -31.25670 0.23841   25.37747  1.000 47.74517  ? 232 LEU A CD2  1 
ATOM   3520 H H    . LEU A 1 232 ? -28.74818 -1.87867  27.65750  1.000 44.79988  ? 232 LEU A H    1 
ATOM   3521 H HA   . LEU A 1 232 ? -28.99936 -1.03101  25.22729  1.000 44.38117  ? 232 LEU A HA   1 
ATOM   3522 H HB2  . LEU A 1 232 ? -28.81660 0.33590   27.65296  1.000 48.87619  ? 232 LEU A HB2  1 
ATOM   3523 H HB3  . LEU A 1 232 ? -28.80951 1.17170   26.30136  1.000 48.87619  ? 232 LEU A HB3  1 
ATOM   3524 H HG   . LEU A 1 232 ? -30.96747 -0.30936  27.31145  1.000 59.24308  ? 232 LEU A HG   1 
ATOM   3525 H HD11 . LEU A 1 232 ? -30.73221 2.47243   26.83867  1.000 71.19820  ? 232 LEU A HD11 1 
ATOM   3526 H HD12 . LEU A 1 232 ? -32.06084 1.78005   27.36674  1.000 71.19820  ? 232 LEU A HD12 1 
ATOM   3527 H HD13 . LEU A 1 232 ? -30.76029 1.80223   28.27865  1.000 71.19820  ? 232 LEU A HD13 1 
ATOM   3528 H HD21 . LEU A 1 232 ? -31.16101 -0.68901  25.10983  1.000 57.28125  ? 232 LEU A HD21 1 
ATOM   3529 H HD22 . LEU A 1 232 ? -32.19622 0.47686   25.41411  1.000 57.28125  ? 232 LEU A HD22 1 
ATOM   3530 H HD23 . LEU A 1 232 ? -30.79372 0.81366   24.74848  1.000 57.28125  ? 232 LEU A HD23 1 
ATOM   3531 N N    . VAL A 1 233 ? -26.06722 -0.54983  26.41586  1.000 36.35806  ? 233 VAL A N    1 
ATOM   3532 C CA   . VAL A 1 233 ? -24.69840 -0.23960  26.01720  1.000 39.41342  ? 233 VAL A CA   1 
ATOM   3533 C C    . VAL A 1 233 ? -24.06053 -1.42361  25.29890  1.000 38.75718  ? 233 VAL A C    1 
ATOM   3534 O O    . VAL A 1 233 ? -23.33458 -1.24684  24.31567  1.000 40.59727  ? 233 VAL A O    1 
ATOM   3535 C CB   . VAL A 1 233 ? -23.86721 0.18600   27.24064  1.000 43.49923  ? 233 VAL A CB   1 
ATOM   3536 C CG1  . VAL A 1 233 ? -22.40331 0.38156   26.84429  1.000 42.75922  ? 233 VAL A CG1  1 
ATOM   3537 C CG2  . VAL A 1 233 ? -24.43533 1.45503   27.85529  1.000 46.74494  ? 233 VAL A CG2  1 
ATOM   3538 H H    . VAL A 1 233 ? -26.15773 -0.79829  27.23420  1.000 43.61671  ? 233 VAL A H    1 
ATOM   3539 H HA   . VAL A 1 233 ? -24.72655 0.50685   25.39840  1.000 47.28315  ? 233 VAL A HA   1 
ATOM   3540 H HB   . VAL A 1 233 ? -23.90799 -0.51399  27.91090  1.000 52.18613  ? 233 VAL A HB   1 
ATOM   3541 H HG11 . VAL A 1 233 ? -21.94568 0.86087   27.55262  1.000 51.29811  ? 233 VAL A HG11 1 
ATOM   3542 H HG12 . VAL A 1 233 ? -21.99260 -0.48750  26.71404  1.000 51.29811  ? 233 VAL A HG12 1 
ATOM   3543 H HG13 . VAL A 1 233 ? -22.36468 0.89246   26.02065  1.000 51.29811  ? 233 VAL A HG13 1 
ATOM   3544 H HG21 . VAL A 1 233 ? -25.19556 1.74797   27.32885  1.000 56.08097  ? 233 VAL A HG21 1 
ATOM   3545 H HG22 . VAL A 1 233 ? -24.71541 1.26742   28.76483  1.000 56.08097  ? 233 VAL A HG22 1 
ATOM   3546 H HG23 . VAL A 1 233 ? -23.74909 2.14057   27.85525  1.000 56.08097  ? 233 VAL A HG23 1 
ATOM   3547 N N    . ALA A 1 234 ? -24.31700 -2.64439  25.77388  1.000 37.76264  ? 234 ALA A N    1 
ATOM   3548 C CA   . ALA A 1 234 ? -23.66799 -3.81387  25.19151  1.000 35.85596  ? 234 ALA A CA   1 
ATOM   3549 C C    . ALA A 1 234 ? -24.00526 -3.95857  23.71547  1.000 36.07424  ? 234 ALA A C    1 
ATOM   3550 O O    . ALA A 1 234 ? -23.13699 -4.29469  22.90363  1.000 34.85060  ? 234 ALA A O    1 
ATOM   3551 C CB   . ALA A 1 234 ? -24.07689 -5.07442  25.95008  1.000 38.14858  ? 234 ALA A CB   1 
ATOM   3552 H H    . ALA A 1 234 ? -24.85448 -2.81813  26.42236  1.000 45.30221  ? 234 ALA A H    1 
ATOM   3553 H HA   . ALA A 1 234 ? -22.70764 -3.70539  25.27431  1.000 43.01420  ? 234 ALA A HA   1 
ATOM   3554 H HB1  . ALA A 1 234 ? -23.89542 -4.94752  26.89447  1.000 45.76534  ? 234 ALA A HB1  1 
ATOM   3555 H HB2  . ALA A 1 234 ? -25.02424 -5.23183  25.81352  1.000 45.76534  ? 234 ALA A HB2  1 
ATOM   3556 H HB3  . ALA A 1 234 ? -23.56472 -5.82601  25.61291  1.000 45.76534  ? 234 ALA A HB3  1 
ATOM   3557 N N    . MET A 1 235 ? -25.25986 -3.70791  23.34492  1.000 37.06897  ? 235 MET A N    1 
ATOM   3558 C CA   . MET A 1 235 ? -25.67854 -3.94043  21.97013  1.000 38.63975  ? 235 MET A CA   1 
ATOM   3559 C C    . MET A 1 235 ? -25.26294 -2.81927  21.02580  1.000 36.86097  ? 235 MET A C    1 
ATOM   3560 O O    . MET A 1 235 ? -25.27082 -3.02466  19.80747  1.000 34.59496  ? 235 MET A O    1 
ATOM   3561 C CB   . MET A 1 235 ? -27.18952 -4.16176  21.92508  1.000 45.41474  ? 235 MET A CB   1 
ATOM   3562 C CG   . MET A 1 235 ? -27.58856 -5.53471  22.45177  1.000 51.34461  ? 235 MET A CG   1 
ATOM   3563 S SD   . MET A 1 235 ? -29.31117 -5.95569  22.14424  1.000 91.74335  ? 235 MET A SD   1 
ATOM   3564 C CE   . MET A 1 235 ? -30.07517 -5.38155  23.65576  1.000 49.25013  ? 235 MET A CE   1 
ATOM   3565 H H    . MET A 1 235 ? -25.87612 -3.40758  23.86416  1.000 44.46981  ? 235 MET A H    1 
ATOM   3566 H HA   . MET A 1 235 ? -25.26197 -4.75462  21.64691  1.000 46.35474  ? 235 MET A HA   1 
ATOM   3567 H HB2  . MET A 1 235 ? -27.62525 -3.48968  22.47221  1.000 54.48474  ? 235 MET A HB2  1 
ATOM   3568 H HB3  . MET A 1 235 ? -27.49360 -4.09012  21.00676  1.000 54.48474  ? 235 MET A HB3  1 
ATOM   3569 H HG2  . MET A 1 235 ? -27.03818 -6.20685  22.02025  1.000 61.60057  ? 235 MET A HG2  1 
ATOM   3570 H HG3  . MET A 1 235 ? -27.44579 -5.55486  23.41099  1.000 61.60057  ? 235 MET A HG3  1 
ATOM   3571 H HE1  . MET A 1 235 ? -31.03826 -5.46267  23.57341  1.000 59.08721  ? 235 MET A HE1  1 
ATOM   3572 H HE2  . MET A 1 235 ? -29.75952 -5.92433  24.39512  1.000 59.08721  ? 235 MET A HE2  1 
ATOM   3573 H HE3  . MET A 1 235 ? -29.83249 -4.45346  23.79953  1.000 59.08721  ? 235 MET A HE3  1 
ATOM   3574 N N    . LYS A 1 236 ? -24.89080 -1.64751  21.54821  1.000 37.74536  ? 236 LYS A N    1 
ATOM   3575 C CA   . LYS A 1 236 ? -24.14435 -0.69865  20.72846  1.000 37.90794  ? 236 LYS A CA   1 
ATOM   3576 C C    . LYS A 1 236 ? -22.82960 -1.31178  20.26368  1.000 37.58187  ? 236 LYS A C    1 
ATOM   3577 O O    . LYS A 1 236 ? -22.28972 -0.91784  19.22442  1.000 38.58159  ? 236 LYS A O    1 
ATOM   3578 C CB   . LYS A 1 236 ? -23.88446 0.59383   21.50900  1.000 40.64531  ? 236 LYS A CB   1 
ATOM   3579 C CG   . LYS A 1 236 ? -22.95012 1.58858   20.80558  1.000 47.62259  ? 236 LYS A CG   1 
ATOM   3580 C CD   . LYS A 1 236 ? -22.66943 2.82588   21.67240  1.000 46.61002  ? 236 LYS A CD   1 
ATOM   3581 C CE   . LYS A 1 236 ? -21.17030 3.11065   21.83299  1.000 43.14988  ? 236 LYS A CE   1 
ATOM   3582 N NZ   . LYS A 1 236 ? -20.75406 4.40908   21.21718  1.000 41.70598  ? 236 LYS A NZ   1 
ATOM   3583 H H    . LYS A 1 236 ? -25.05421 -1.38716  22.35140  1.000 45.28147  ? 236 LYS A H    1 
ATOM   3584 H HA   . LYS A 1 236 ? -24.67263 -0.46491  19.94924  1.000 45.47657  ? 236 LYS A HA   1 
ATOM   3585 H HB2  . LYS A 1 236 ? -24.73231 1.04189   21.65490  1.000 48.76142  ? 236 LYS A HB2  1 
ATOM   3586 H HB3  . LYS A 1 236 ? -23.47982 0.36415   22.36012  1.000 48.76142  ? 236 LYS A HB3  1 
ATOM   3587 H HG2  . LYS A 1 236 ? -22.10421 1.15325   20.61631  1.000 57.13415  ? 236 LYS A HG2  1 
ATOM   3588 H HG3  . LYS A 1 236 ? -23.36285 1.88503   19.97934  1.000 57.13415  ? 236 LYS A HG3  1 
ATOM   3589 H HD2  . LYS A 1 236 ? -23.07900 3.60171   21.25859  1.000 55.91907  ? 236 LYS A HD2  1 
ATOM   3590 H HD3  . LYS A 1 236 ? -23.04381 2.68477   22.55604  1.000 55.91907  ? 236 LYS A HD3  1 
ATOM   3591 H HE2  . LYS A 1 236 ? -20.95516 3.14552   22.77819  1.000 51.76690  ? 236 LYS A HE2  1 
ATOM   3592 H HE3  . LYS A 1 236 ? -20.66659 2.40130   21.40404  1.000 51.76690  ? 236 LYS A HE3  1 
ATOM   3593 H HZ1  . LYS A 1 236 ? -19.86736 4.48374   21.23441  1.000 50.03423  ? 236 LYS A HZ1  1 
ATOM   3594 H HZ2  . LYS A 1 236 ? -21.03081 4.44779   20.37219  1.000 50.03423  ? 236 LYS A HZ2  1 
ATOM   3595 H HZ3  . LYS A 1 236 ? -21.10994 5.08823   21.66907  1.000 50.03423  ? 236 LYS A HZ3  1 
ATOM   3596 N N    . TYR A 1 237 ? -22.31162 -2.28537  21.01484  1.000 37.92941  ? 237 TYR A N    1 
ATOM   3597 C CA   . TYR A 1 237 ? -21.03277 -2.92240  20.73637  1.000 37.27920  ? 237 TYR A CA   1 
ATOM   3598 C C    . TYR A 1 237 ? -21.18996 -4.31699  20.13614  1.000 32.77931  ? 237 TYR A C    1 
ATOM   3599 O O    . TYR A 1 237 ? -20.23756 -5.10435  20.15088  1.000 32.86521  ? 237 TYR A O    1 
ATOM   3600 C CB   . TYR A 1 237 ? -20.19976 -2.98628  22.01766  1.000 34.05728  ? 237 TYR A CB   1 
ATOM   3601 C CG   . TYR A 1 237 ? -19.67209 -1.63885  22.45193  1.000 36.35842  ? 237 TYR A CG   1 
ATOM   3602 C CD1  . TYR A 1 237 ? -20.43121 -0.79896  23.25626  1.000 35.68123  ? 237 TYR A CD1  1 
ATOM   3603 C CD2  . TYR A 1 237 ? -18.41733 -1.20060  22.04461  1.000 36.92170  ? 237 TYR A CD2  1 
ATOM   3604 C CE1  . TYR A 1 237 ? -19.95337 0.43946   23.64615  1.000 38.89735  ? 237 TYR A CE1  1 
ATOM   3605 C CE2  . TYR A 1 237 ? -17.93120 0.03482   22.43032  1.000 37.56084  ? 237 TYR A CE2  1 
ATOM   3606 C CZ   . TYR A 1 237 ? -18.70248 0.84952   23.23237  1.000 38.65097  ? 237 TYR A CZ   1 
ATOM   3607 O OH   . TYR A 1 237 ? -18.22486 2.08052   23.61460  1.000 38.22595  ? 237 TYR A OH   1 
ATOM   3608 H H    . TYR A 1 237 ? -22.69917 -2.60177  21.71433  1.000 45.50233  ? 237 TYR A H    1 
ATOM   3609 H HA   . TYR A 1 237 ? -20.55349 -2.38260  20.08844  1.000 44.72209  ? 237 TYR A HA   1 
ATOM   3610 H HB2  . TYR A 1 237 ? -20.75224 -3.33561  22.73435  1.000 40.85578  ? 237 TYR A HB2  1 
ATOM   3611 H HB3  . TYR A 1 237 ? -19.43995 -3.57077  21.86947  1.000 40.85578  ? 237 TYR A HB3  1 
ATOM   3612 H HD1  . TYR A 1 237 ? -21.27420 -1.07336  23.53728  1.000 42.80452  ? 237 TYR A HD1  1 
ATOM   3613 H HD2  . TYR A 1 237 ? -17.89576 -1.74804  21.50316  1.000 44.29309  ? 237 TYR A HD2  1 
ATOM   3614 H HE1  . TYR A 1 237 ? -20.47242 0.99260   24.18421  1.000 46.66387  ? 237 TYR A HE1  1 
ATOM   3615 H HE2  . TYR A 1 237 ? -17.08953 0.31467   22.15071  1.000 45.06005  ? 237 TYR A HE2  1 
ATOM   3616 H HH   . TYR A 1 237 ? -18.86356 2.61475   23.72535  1.000 45.85819  ? 237 TYR A HH   1 
ATOM   3617 N N    . ASN A 1 238 ? -22.36822 -4.63597  19.60791  1.000 32.34223  ? 238 ASN A N    1 
ATOM   3618 C CA   . ASN A 1 238 ? -22.61734 -5.92918  18.97281  1.000 33.48070  ? 238 ASN A CA   1 
ATOM   3619 C C    . ASN A 1 238 ? -22.35948 -7.08527  19.93771  1.000 33.08939  ? 238 ASN A C    1 
ATOM   3620 O O    . ASN A 1 238 ? -21.85175 -8.13905  19.55391  1.000 34.09487  ? 238 ASN A O    1 
ATOM   3621 C CB   . ASN A 1 238 ? -21.78412 -6.08114  17.69815  1.000 34.40470  ? 238 ASN A CB   1 
ATOM   3622 C CG   . ASN A 1 238 ? -22.45221 -5.45007  16.49329  1.000 35.77598  ? 238 ASN A CG   1 
ATOM   3623 O OD1  . ASN A 1 238 ? -23.67476 -5.49077  16.35735  1.000 36.65340  ? 238 ASN A OD1  1 
ATOM   3624 N ND2  . ASN A 1 238 ? -21.65415 -4.86114  15.61313  1.000 36.71353  ? 238 ASN A ND2  1 
ATOM   3625 H H    . ASN A 1 238 ? -23.05077 -4.11279  19.60421  1.000 38.79772  ? 238 ASN A H    1 
ATOM   3626 H HA   . ASN A 1 238 ? -23.55412 -5.97180  18.72478  1.000 40.16388  ? 238 ASN A HA   1 
ATOM   3627 H HB2  . ASN A 1 238 ? -20.92503 -5.64957  17.82703  1.000 41.27268  ? 238 ASN A HB2  1 
ATOM   3628 H HB3  . ASN A 1 238 ? -21.65688 -7.02468  17.51259  1.000 41.27268  ? 238 ASN A HB3  1 
ATOM   3629 H HD21 . ASN A 1 238 ? -21.98672 -4.48882  14.91286  1.000 44.04328  ? 238 ASN A HD21 1 
ATOM   3630 H HD22 . ASN A 1 238 ? -20.80400 -4.85152  15.74257  1.000 44.04328  ? 238 ASN A HD22 1 
ATOM   3631 N N    . TYR A 1 239 ? -22.71578 -6.88507  21.20277  1.000 32.19413  ? 239 TYR A N    1 
ATOM   3632 C CA   . TYR A 1 239 ? -22.72560 -7.95861  22.18546  1.000 31.71208  ? 239 TYR A CA   1 
ATOM   3633 C C    . TYR A 1 239 ? -24.10706 -8.59834  22.22364  1.000 33.08884  ? 239 TYR A C    1 
ATOM   3634 O O    . TYR A 1 239 ? -25.12578 -7.90134  22.19479  1.000 33.66931  ? 239 TYR A O    1 
ATOM   3635 C CB   . TYR A 1 239 ? -22.36431 -7.42880  23.57288  1.000 30.91067  ? 239 TYR A CB   1 
ATOM   3636 C CG   . TYR A 1 239 ? -20.89090 -7.47991  23.90034  1.000 31.49697  ? 239 TYR A CG   1 
ATOM   3637 C CD1  . TYR A 1 239 ? -19.95284 -6.89340  23.06834  1.000 29.17526  ? 239 TYR A CD1  1 
ATOM   3638 C CD2  . TYR A 1 239 ? -20.44163 -8.10377  25.05567  1.000 29.20960  ? 239 TYR A CD2  1 
ATOM   3639 C CE1  . TYR A 1 239 ? -18.60424 -6.93694  23.36809  1.000 28.90862  ? 239 TYR A CE1  1 
ATOM   3640 C CE2  . TYR A 1 239 ? -19.09751 -8.15124  25.36166  1.000 29.83344  ? 239 TYR A CE2  1 
ATOM   3641 C CZ   . TYR A 1 239 ? -18.18363 -7.56848  24.51120  1.000 29.27442  ? 239 TYR A CZ   1 
ATOM   3642 O OH   . TYR A 1 239 ? -16.84170 -7.60830  24.80963  1.000 32.94025  ? 239 TYR A OH   1 
ATOM   3643 H H    . TYR A 1 239 ? -22.95952 -6.12366  21.51969  1.000 38.62000  ? 239 TYR A H    1 
ATOM   3644 H HA   . TYR A 1 239 ? -22.07039 -8.63100  21.94155  1.000 38.04154  ? 239 TYR A HA   1 
ATOM   3645 H HB2  . TYR A 1 239 ? -22.64533 -6.50231  23.63237  1.000 37.07985  ? 239 TYR A HB2  1 
ATOM   3646 H HB3  . TYR A 1 239 ? -22.83034 -7.96015  24.23725  1.000 37.07985  ? 239 TYR A HB3  1 
ATOM   3647 H HD1  . TYR A 1 239 ? -20.23500 -6.46246  22.29401  1.000 34.99736  ? 239 TYR A HD1  1 
ATOM   3648 H HD2  . TYR A 1 239 ? -21.05650 -8.49604  25.63270  1.000 35.03857  ? 239 TYR A HD2  1 
ATOM   3649 H HE1  . TYR A 1 239 ? -17.98546 -6.54041  22.79819  1.000 34.67739  ? 239 TYR A HE1  1 
ATOM   3650 H HE2  . TYR A 1 239 ? -18.80961 -8.57447  26.13812  1.000 35.78718  ? 239 TYR A HE2  1 
ATOM   3651 H HH   . TYR A 1 239 ? -16.41413 -7.12034  24.27608  1.000 39.51534  ? 239 TYR A HH   1 
ATOM   3652 N N    . GLU A 1 240 ? -24.13839 -9.92420  22.27608  1.000 31.16812  ? 240 GLU A N    1 
ATOM   3653 C CA   . GLU A 1 240 ? -25.40916 -10.61051 22.44965  1.000 33.86896  ? 240 GLU A CA   1 
ATOM   3654 C C    . GLU A 1 240 ? -26.08904 -10.09335 23.71520  1.000 34.14804  ? 240 GLU A C    1 
ATOM   3655 O O    . GLU A 1 240 ? -25.41918 -9.87517  24.73232  1.000 31.72197  ? 240 GLU A O    1 
ATOM   3656 C CB   . GLU A 1 240 ? -25.20504 -12.12425 22.54253  1.000 34.96732  ? 240 GLU A CB   1 
ATOM   3657 C CG   . GLU A 1 240 ? -24.88505 -12.79702 21.21208  1.000 36.61294  ? 240 GLU A CG   1 
ATOM   3658 C CD   . GLU A 1 240 ? -26.02112 -12.68964 20.21300  1.000 42.12089  ? 240 GLU A CD   1 
ATOM   3659 O OE1  . GLU A 1 240 ? -27.15991 -13.06014 20.56445  1.000 48.57032  ? 240 GLU A OE1  1 
ATOM   3660 O OE2  . GLU A 1 240 ? -25.77972 -12.22685 19.07872  1.000 43.41181  ? 240 GLU A OE2  1 
ATOM   3661 H H    . GLU A 1 240 ? -23.45225 -10.43906 22.21495  1.000 37.38879  ? 240 GLU A H    1 
ATOM   3662 H HA   . GLU A 1 240 ? -25.98282 -10.43732 21.68689  1.000 40.62980  ? 240 GLU A HA   1 
ATOM   3663 H HB2  . GLU A 1 240 ? -24.46652 -12.30071 23.14615  1.000 41.94783  ? 240 GLU A HB2  1 
ATOM   3664 H HB3  . GLU A 1 240 ? -26.01812 -12.52584 22.88681  1.000 41.94783  ? 240 GLU A HB3  1 
ATOM   3665 H HG2  . GLU A 1 240 ? -24.10311 -12.37417 20.82391  1.000 43.92258  ? 240 GLU A HG2  1 
ATOM   3666 H HG3  . GLU A 1 240 ? -24.71028 -13.73837 21.36771  1.000 43.92258  ? 240 GLU A HG3  1 
ATOM   3667 N N    . PRO A 1 241 ? -27.40315 -9.86864  23.69137  1.000 34.27425  ? 241 PRO A N    1 
ATOM   3668 C CA   . PRO A 1 241 ? -28.07700 -9.38780  24.90386  1.000 36.71365  ? 241 PRO A CA   1 
ATOM   3669 C C    . PRO A 1 241 ? -27.99632 -10.41081 26.02574  1.000 35.46371  ? 241 PRO A C    1 
ATOM   3670 O O    . PRO A 1 241 ? -28.08913 -11.61998 25.80017  1.000 36.78757  ? 241 PRO A O    1 
ATOM   3671 C CB   . PRO A 1 241 ? -29.52194 -9.16204  24.44496  1.000 39.06462  ? 241 PRO A CB   1 
ATOM   3672 C CG   . PRO A 1 241 ? -29.68277 -10.05366 23.25211  1.000 36.96778  ? 241 PRO A CG   1 
ATOM   3673 C CD   . PRO A 1 241 ? -28.34679 -10.05395 22.57461  1.000 34.34756  ? 241 PRO A CD   1 
ATOM   3674 H HA   . PRO A 1 241 ? -27.69333 -8.54758  25.20003  1.000 44.04342  ? 241 PRO A HA   1 
ATOM   3675 H HB2  . PRO A 1 241 ? -30.13741 -9.41133  25.15204  1.000 46.86459  ? 241 PRO A HB2  1 
ATOM   3676 H HB3  . PRO A 1 241 ? -29.65216 -8.23135  24.20462  1.000 46.86459  ? 241 PRO A HB3  1 
ATOM   3677 H HG2  . PRO A 1 241 ? -29.92442 -10.94797 23.53971  1.000 44.34838  ? 241 PRO A HG2  1 
ATOM   3678 H HG3  . PRO A 1 241 ? -30.36779 -9.69758  22.66486  1.000 44.34838  ? 241 PRO A HG3  1 
ATOM   3679 H HD2  . PRO A 1 241 ? -28.18783 -10.89827 22.12433  1.000 41.20411  ? 241 PRO A HD2  1 
ATOM   3680 H HD3  . PRO A 1 241 ? -28.28041 -9.32244  21.94107  1.000 41.20411  ? 241 PRO A HD3  1 
ATOM   3681 N N    . LEU A 1 242 ? -27.81483 -9.90832  27.24587  1.000 35.82980  ? 242 LEU A N    1 
ATOM   3682 C CA   . LEU A 1 242 ? -27.67546 -10.74738 28.42735  1.000 34.49247  ? 242 LEU A CA   1 
ATOM   3683 C C    . LEU A 1 242 ? -29.03992 -10.93817 29.07972  1.000 36.31983  ? 242 LEU A C    1 
ATOM   3684 O O    . LEU A 1 242 ? -29.79125 -9.97475  29.25824  1.000 35.21635  ? 242 LEU A O    1 
ATOM   3685 C CB   . LEU A 1 242 ? -26.69115 -10.11444 29.41256  1.000 34.22906  ? 242 LEU A CB   1 
ATOM   3686 C CG   . LEU A 1 242 ? -26.21944 -10.97498 30.58408  1.000 35.21862  ? 242 LEU A CG   1 
ATOM   3687 C CD1  . LEU A 1 242 ? -25.16229 -11.97860 30.13621  1.000 34.28005  ? 242 LEU A CD1  1 
ATOM   3688 C CD2  . LEU A 1 242 ? -25.68425 -10.09314 31.70676  1.000 32.38951  ? 242 LEU A CD2  1 
ATOM   3689 H H    . LEU A 1 242 ? -27.76839 -9.06654  27.41574  1.000 42.98280  ? 242 LEU A H    1 
ATOM   3690 H HA   . LEU A 1 242 ? -27.33426 -11.62001 28.17635  1.000 41.37800  ? 242 LEU A HA   1 
ATOM   3691 H HB2  . LEU A 1 242 ? -25.89880 -9.85607  28.91625  1.000 41.06192  ? 242 LEU A HB2  1 
ATOM   3692 H HB3  . LEU A 1 242 ? -27.11506 -9.32926  29.79295  1.000 41.06192  ? 242 LEU A HB3  1 
ATOM   3693 H HG   . LEU A 1 242 ? -26.97436 -11.47907 30.92597  1.000 42.24939  ? 242 LEU A HG   1 
ATOM   3694 H HD11 . LEU A 1 242 ? -25.13152 -12.71001 30.77259  1.000 41.12311  ? 242 LEU A HD11 1 
ATOM   3695 H HD12 . LEU A 1 242 ? -25.39804 -12.31454 29.25731  1.000 41.12311  ? 242 LEU A HD12 1 
ATOM   3696 H HD13 . LEU A 1 242 ? -24.30053 -11.53476 30.10048  1.000 41.12311  ? 242 LEU A HD13 1 
ATOM   3697 H HD21 . LEU A 1 242 ? -24.92480 -10.53343 32.11942  1.000 38.85446  ? 242 LEU A HD21 1 
ATOM   3698 H HD22 . LEU A 1 242 ? -25.41021 -9.24016  31.33499  1.000 38.85446  ? 242 LEU A HD22 1 
ATOM   3699 H HD23 . LEU A 1 242 ? -26.38517 -9.95787  32.36351  1.000 38.85446  ? 242 LEU A HD23 1 
ATOM   3700 N N    . THR A 1 243 ? -29.35176 -12.17889 29.43581  1.000 35.42455  ? 243 THR A N    1 
ATOM   3701 C CA   . THR A 1 243 ? -30.65641 -12.55435 29.95622  1.000 37.93158  ? 243 THR A CA   1 
ATOM   3702 C C    . THR A 1 243 ? -30.52191 -13.06523 31.38424  1.000 36.51597  ? 243 THR A C    1 
ATOM   3703 O O    . THR A 1 243 ? -29.42127 -13.31235 31.88238  1.000 34.78881  ? 243 THR A O    1 
ATOM   3704 C CB   . THR A 1 243 ? -31.30617 -13.63362 29.08216  1.000 40.05593  ? 243 THR A CB   1 
ATOM   3705 O OG1  . THR A 1 243 ? -30.64590 -14.88641 29.30187  1.000 40.09989  ? 243 THR A OG1  1 
ATOM   3706 C CG2  . THR A 1 243 ? -31.18895 -13.26973 27.61591  1.000 44.13812  ? 243 THR A CG2  1 
ATOM   3707 H H    . THR A 1 243 ? -28.80485 -12.84044 29.38251  1.000 42.49651  ? 243 THR A H    1 
ATOM   3708 H HA   . THR A 1 243 ? -31.22864 -11.77115 29.96275  1.000 45.50494  ? 243 THR A HA   1 
ATOM   3709 H HB   . THR A 1 243 ? -32.24587 -13.71118 29.30990  1.000 48.05417  ? 243 THR A HB   1 
ATOM   3710 H HG1  . THR A 1 243 ? -30.81783 -15.41597 28.67289  1.000 48.10691  ? 243 THR A HG1  1 
ATOM   3711 H HG21 . THR A 1 243 ? -31.39085 -12.32932 27.49031  1.000 52.95279  ? 243 THR A HG21 1 
ATOM   3712 H HG22 . THR A 1 243 ? -30.28756 -13.44281 27.30217  1.000 52.95279  ? 243 THR A HG22 1 
ATOM   3713 H HG23 . THR A 1 243 ? -31.81144 -13.79803 27.09218  1.000 52.95279  ? 243 THR A HG23 1 
ATOM   3714 N N    . GLN A 1 244 ? -31.67171 -13.23737 32.04203  1.000 37.15894  ? 244 GLN A N    1 
ATOM   3715 C CA   . GLN A 1 244 ? -31.66220 -13.72650 33.41681  1.000 35.91970  ? 244 GLN A CA   1 
ATOM   3716 C C    . GLN A 1 244 ? -31.14610 -15.15742 33.49855  1.000 37.23006  ? 244 GLN A C    1 
ATOM   3717 O O    . GLN A 1 244 ? -30.55765 -15.54556 34.51423  1.000 36.74540  ? 244 GLN A O    1 
ATOM   3718 C CB   . GLN A 1 244 ? -33.06500 -13.63075 34.02068  1.000 36.70464  ? 244 GLN A CB   1 
ATOM   3719 C CG   . GLN A 1 244 ? -33.15139 -14.07462 35.47258  1.000 36.51079  ? 244 GLN A CG   1 
ATOM   3720 C CD   . GLN A 1 244 ? -32.22739 -13.28870 36.38089  1.000 37.24403  ? 244 GLN A CD   1 
ATOM   3721 O OE1  . GLN A 1 244 ? -32.06340 -12.08048 36.22163  1.000 36.25062  ? 244 GLN A OE1  1 
ATOM   3722 N NE2  . GLN A 1 244 ? -31.61355 -13.97454 37.33827  1.000 37.50387  ? 244 GLN A NE2  1 
ATOM   3723 H H    . GLN A 1 244 ? -32.45360 -13.08095 31.71989  1.000 44.57778  ? 244 GLN A H    1 
ATOM   3724 H HA   . GLN A 1 244 ? -31.07252 -13.16442 33.94336  1.000 43.09069  ? 244 GLN A HA   1 
ATOM   3725 H HB2  . GLN A 1 244 ? -33.35862 -12.70726 33.97752  1.000 44.03262  ? 244 GLN A HB2  1 
ATOM   3726 H HB3  . GLN A 1 244 ? -33.66347 -14.19360 33.50499  1.000 44.03262  ? 244 GLN A HB3  1 
ATOM   3727 H HG2  . GLN A 1 244 ? -34.06009 -13.94943 35.78800  1.000 43.80000  ? 244 GLN A HG2  1 
ATOM   3728 H HG3  . GLN A 1 244 ? -32.90558 -15.01106 35.53213  1.000 43.80000  ? 244 GLN A HG3  1 
ATOM   3729 H HE21 . GLN A 1 244 ? -31.75062 -14.81988 37.41707  1.000 44.99168  ? 244 GLN A HE21 1 
ATOM   3730 H HE22 . GLN A 1 244 ? -31.07898 -13.57332 37.87943  1.000 44.99168  ? 244 GLN A HE22 1 
ATOM   3731 N N    . ASP A 1 245 ? -31.35862 -15.95772 32.45222  1.000 41.18555  ? 245 ASP A N    1 
ATOM   3732 C CA   . ASP A 1 245 ? -30.77071 -17.29315 32.42955  1.000 43.28062  ? 245 ASP A CA   1 
ATOM   3733 C C    . ASP A 1 245 ? -29.24960 -17.21549 32.41704  1.000 39.40247  ? 245 ASP A C    1 
ATOM   3734 O O    . ASP A 1 245 ? -28.57839 -17.94510 33.15573  1.000 37.66647  ? 245 ASP A O    1 
ATOM   3735 C CB   . ASP A 1 245 ? -31.28330 -18.07652 31.22078  1.000 44.86591  ? 245 ASP A CB   1 
ATOM   3736 C CG   . ASP A 1 245 ? -32.70119 -18.58281 31.41353  1.000 46.23024  ? 245 ASP A CG   1 
ATOM   3737 O OD1  . ASP A 1 245 ? -33.24007 -18.44092 32.53052  1.000 45.16160  ? 245 ASP A OD1  1 
ATOM   3738 O OD2  . ASP A 1 245 ? -33.27794 -19.12418 30.44788  1.000 47.98941  ? 245 ASP A OD2  1 
ATOM   3739 H H    . ASP A 1 245 ? -31.82789 -15.75536 31.76053  1.000 49.40971  ? 245 ASP A H    1 
ATOM   3740 H HA   . ASP A 1 245 ? -31.04373 -17.77209 33.22766  1.000 51.92379  ? 245 ASP A HA   1 
ATOM   3741 H HB2  . ASP A 1 245 ? -31.27350 -17.49893 30.44155  1.000 53.82614  ? 245 ASP A HB2  1 
ATOM   3742 H HB3  . ASP A 1 245 ? -30.70771 -18.84313 31.07276  1.000 53.82614  ? 245 ASP A HB3  1 
ATOM   3743 N N    . HIS A 1 246 ? -28.68717 -16.33377 31.58535  1.000 39.53225  ? 246 HIS A N    1 
ATOM   3744 C CA   . HIS A 1 246 ? -27.24561 -16.09943 31.62314  1.000 37.36295  ? 246 HIS A CA   1 
ATOM   3745 C C    . HIS A 1 246 ? -26.79867 -15.70718 33.02765  1.000 35.42138  ? 246 HIS A C    1 
ATOM   3746 O O    . HIS A 1 246 ? -25.80311 -16.22529 33.54488  1.000 33.76259  ? 246 HIS A O    1 
ATOM   3747 C CB   . HIS A 1 246 ? -26.86069 -15.00903 30.62163  1.000 37.41479  ? 246 HIS A CB   1 
ATOM   3748 C CG   . HIS A 1 246 ? -27.12324 -15.36820 29.19160  1.000 37.14340  ? 246 HIS A CG   1 
ATOM   3749 N ND1  . HIS A 1 246 ? -27.55372 -14.44580 28.26314  1.000 38.23896  ? 246 HIS A ND1  1 
ATOM   3750 C CD2  . HIS A 1 246 ? -26.99500 -16.53934 28.52511  1.000 36.86641  ? 246 HIS A CD2  1 
ATOM   3751 C CE1  . HIS A 1 246 ? -27.69523 -15.03589 27.09030  1.000 39.48998  ? 246 HIS A CE1  1 
ATOM   3752 N NE2  . HIS A 1 246 ? -27.36170 -16.30666 27.22185  1.000 38.97638  ? 246 HIS A NE2  1 
ATOM   3753 H H    . HIS A 1 246 ? -29.11177 -15.86735 31.00074  1.000 47.42574  ? 246 HIS A H    1 
ATOM   3754 H HA   . HIS A 1 246 ? -26.79022 -16.91732 31.36904  1.000 44.82259  ? 246 HIS A HA   1 
ATOM   3755 H HB2  . HIS A 1 246 ? -27.37134 -14.20917 30.82252  1.000 44.88479  ? 246 HIS A HB2  1 
ATOM   3756 H HB3  . HIS A 1 246 ? -25.91187 -14.82779 30.70993  1.000 44.88479  ? 246 HIS A HB3  1 
ATOM   3757 H HD2  . HIS A 1 246 ? -26.71167 -17.34979 28.88257  1.000 44.22674  ? 246 HIS A HD2  1 
ATOM   3758 H HE1  . HIS A 1 246 ? -27.98098 -14.62639 26.30573  1.000 47.37502  ? 246 HIS A HE1  1 
ATOM   3759 H HE2  . HIS A 1 246 ? -27.37232 -16.89364 26.59340  1.000 46.75871  ? 246 HIS A HE2  1 
ATOM   3760 N N    . VAL A 1 247 ? -27.52287 -14.77761 33.65693  1.000 35.98967  ? 247 VAL A N    1 
ATOM   3761 C CA   . VAL A 1 247 ? -27.21877 -14.40043 35.03627  1.000 33.53435  ? 247 VAL A CA   1 
ATOM   3762 C C    . VAL A 1 247 ? -27.21728 -15.63440 35.92992  1.000 34.21778  ? 247 VAL A C    1 
ATOM   3763 O O    . VAL A 1 247 ? -26.28986 -15.85653 36.71703  1.000 34.51314  ? 247 VAL A O    1 
ATOM   3764 C CB   . VAL A 1 247 ? -28.22429 -13.34857 35.53771  1.000 35.32505  ? 247 VAL A CB   1 
ATOM   3765 C CG1  . VAL A 1 247 ? -27.96462 -13.02094 36.99926  1.000 29.53904  ? 247 VAL A CG1  1 
ATOM   3766 C CG2  . VAL A 1 247 ? -28.15420 -12.09177 34.68284  1.000 35.30874  ? 247 VAL A CG2  1 
ATOM   3767 H H    . VAL A 1 247 ? -28.18756 -14.35584 33.31068  1.000 43.17465  ? 247 VAL A H    1 
ATOM   3768 H HA   . VAL A 1 247 ? -26.33245 -14.00714 35.06190  1.000 40.22826  ? 247 VAL A HA   1 
ATOM   3769 H HB   . VAL A 1 247 ? -29.12106 -13.71094 35.46430  1.000 42.37710  ? 247 VAL A HB   1 
ATOM   3770 H HG11 . VAL A 1 247 ? -28.60778 -13.49591 37.54847  1.000 35.43390  ? 247 VAL A HG11 1 
ATOM   3771 H HG12 . VAL A 1 247 ? -27.06412 -13.29812 37.22987  1.000 35.43390  ? 247 VAL A HG12 1 
ATOM   3772 H HG13 . VAL A 1 247 ? -28.06011 -12.06458 37.13031  1.000 35.43390  ? 247 VAL A HG13 1 
ATOM   3773 H HG21 . VAL A 1 247 ? -28.80432 -11.45057 35.01011  1.000 42.35754  ? 247 VAL A HG21 1 
ATOM   3774 H HG22 . VAL A 1 247 ? -27.26124 -11.71785 34.74368  1.000 42.35754  ? 247 VAL A HG22 1 
ATOM   3775 H HG23 . VAL A 1 247 ? -28.35340 -12.32437 33.76245  1.000 42.35754  ? 247 VAL A HG23 1 
ATOM   3776 N N    . ASP A 1 248 ? -28.26614 -16.45445 35.82220  1.000 36.16172  ? 248 ASP A N    1 
ATOM   3777 C CA   . ASP A 1 248 ? -28.33049 -17.68664 36.60358  1.000 35.72544  ? 248 ASP A CA   1 
ATOM   3778 C C    . ASP A 1 248 ? -27.11309 -18.56872 36.35359  1.000 34.96952  ? 248 ASP A C    1 
ATOM   3779 O O    . ASP A 1 248 ? -26.54188 -19.13571 37.29362  1.000 35.06816  ? 248 ASP A O    1 
ATOM   3780 C CB   . ASP A 1 248 ? -29.61467 -18.44722 36.26838  1.000 37.90758  ? 248 ASP A CB   1 
ATOM   3781 C CG   . ASP A 1 248 ? -30.86311 -17.71820 36.72422  1.000 41.08618  ? 248 ASP A CG   1 
ATOM   3782 O OD1  . ASP A 1 248 ? -30.74008 -16.73229 37.48480  1.000 40.93817  ? 248 ASP A OD1  1 
ATOM   3783 O OD2  . ASP A 1 248 ? -31.97021 -18.12757 36.31838  1.000 45.45474  ? 248 ASP A OD2  1 
ATOM   3784 H H    . ASP A 1 248 ? -28.94410 -16.32100 35.31019  1.000 43.38110  ? 248 ASP A H    1 
ATOM   3785 H HA   . ASP A 1 248 ? -28.34616 -17.45727 37.54594  1.000 42.85758  ? 248 ASP A HA   1 
ATOM   3786 H HB2  . ASP A 1 248 ? -29.67037 -18.56553 35.30724  1.000 45.47614  ? 248 ASP A HB2  1 
ATOM   3787 H HB3  . ASP A 1 248 ? -29.59433 -19.31143 36.70841  1.000 45.47614  ? 248 ASP A HB3  1 
ATOM   3788 N N    . ILE A 1 249 ? -26.69757 -18.69479 35.09158  1.000 34.08281  ? 249 ILE A N    1 
ATOM   3789 C CA   . ILE A 1 249 ? -25.59913 -19.59753 34.76293  1.000 35.22659  ? 249 ILE A CA   1 
ATOM   3790 C C    . ILE A 1 249 ? -24.28835 -19.10157 35.35981  1.000 33.49502  ? 249 ILE A C    1 
ATOM   3791 O O    . ILE A 1 249 ? -23.40178 -19.90304 35.67862  1.000 33.75653  ? 249 ILE A O    1 
ATOM   3792 C CB   . ILE A 1 249 ? -25.49875 -19.77188 33.23503  1.000 36.54336  ? 249 ILE A CB   1 
ATOM   3793 C CG1  . ILE A 1 249 ? -26.75446 -20.46257 32.69930  1.000 36.93055  ? 249 ILE A CG1  1 
ATOM   3794 C CG2  . ILE A 1 249 ? -24.27381 -20.59018 32.86915  1.000 39.48179  ? 249 ILE A CG2  1 
ATOM   3795 C CD1  . ILE A 1 249 ? -26.90329 -20.38554 31.19554  1.000 39.14233  ? 249 ILE A CD1  1 
ATOM   3796 H H    . ILE A 1 249 ? -27.03040 -18.27500 34.41882  1.000 40.88642  ? 249 ILE A H    1 
ATOM   3797 H HA   . ILE A 1 249 ? -25.78657 -20.46525 35.15387  1.000 42.25895  ? 249 ILE A HA   1 
ATOM   3798 H HB   . ILE A 1 249 ? -25.42079 -18.89104 32.83635  1.000 43.83908  ? 249 ILE A HB   1 
ATOM   3799 H HG12 . ILE A 1 249 ? -26.72271 -21.40034 32.94523  1.000 44.30370  ? 249 ILE A HG12 1 
ATOM   3800 H HG13 . ILE A 1 249 ? -27.53380 -20.04200 33.09509  1.000 44.30370  ? 249 ILE A HG13 1 
ATOM   3801 H HG21 . ILE A 1 249 ? -24.27338 -20.74734 31.91197  1.000 47.36520  ? 249 ILE A HG21 1 
ATOM   3802 H HG22 . ILE A 1 249 ? -23.47766 -20.09811 33.12393  1.000 47.36520  ? 249 ILE A HG22 1 
ATOM   3803 H HG23 . ILE A 1 249 ? -24.30584 -21.43585 33.34319  1.000 47.36520  ? 249 ILE A HG23 1 
ATOM   3804 H HD11 . ILE A 1 249 ? -27.80143 -20.65985 30.95263  1.000 46.95784  ? 249 ILE A HD11 1 
ATOM   3805 H HD12 . ILE A 1 249 ? -26.74763 -19.47194 30.90918  1.000 46.95784  ? 249 ILE A HD12 1 
ATOM   3806 H HD13 . ILE A 1 249 ? -26.25402 -20.97660 30.78325  1.000 46.95784  ? 249 ILE A HD13 1 
ATOM   3807 N N    . LEU A 1 250 ? -24.13478 -17.78959 35.51894  1.000 34.70044  ? 250 LEU A N    1 
ATOM   3808 C CA   . LEU A 1 250 ? -22.95638 -17.21763 36.15733  1.000 34.81311  ? 250 LEU A CA   1 
ATOM   3809 C C    . LEU A 1 250 ? -23.08495 -17.16299 37.67500  1.000 35.49509  ? 250 LEU A C    1 
ATOM   3810 O O    . LEU A 1 250 ? -22.20613 -16.60478 38.34020  1.000 35.73413  ? 250 LEU A O    1 
ATOM   3811 C CB   . LEU A 1 250 ? -22.69063 -15.81201 35.61246  1.000 34.06432  ? 250 LEU A CB   1 
ATOM   3812 C CG   . LEU A 1 250 ? -22.36122 -15.69659 34.12379  1.000 32.38673  ? 250 LEU A CG   1 
ATOM   3813 C CD1  . LEU A 1 250 ? -22.79100 -14.33635 33.59969  1.000 29.24430  ? 250 LEU A CD1  1 
ATOM   3814 C CD2  . LEU A 1 250 ? -20.87077 -15.92726 33.86295  1.000 32.86483  ? 250 LEU A CD2  1 
ATOM   3815 H H    . LEU A 1 250 ? -24.70868 -17.20328 35.26111  1.000 41.62757  ? 250 LEU A H    1 
ATOM   3816 H HA   . LEU A 1 250 ? -22.18955 -17.77043 35.93989  1.000 41.76278  ? 250 LEU A HA   1 
ATOM   3817 H HB2  . LEU A 1 250 ? -23.48376 -15.27604 35.76927  1.000 40.86423  ? 250 LEU A HB2  1 
ATOM   3818 H HB3  . LEU A 1 250 ? -21.93784 -15.44067 36.09858  1.000 40.86423  ? 250 LEU A HB3  1 
ATOM   3819 H HG   . LEU A 1 250 ? -22.84802 -16.38365 33.64225  1.000 38.85112  ? 250 LEU A HG   1 
ATOM   3820 H HD11 . LEU A 1 250 ? -22.62157 -13.66735 34.28133  1.000 35.08020  ? 250 LEU A HD11 1 
ATOM   3821 H HD12 . LEU A 1 250 ? -22.28153 -14.13053 32.80033  1.000 35.08020  ? 250 LEU A HD12 1 
ATOM   3822 H HD13 . LEU A 1 250 ? -23.73784 -14.36321 33.39069  1.000 35.08020  ? 250 LEU A HD13 1 
ATOM   3823 H HD21 . LEU A 1 250 ? -20.66810 -15.67817 32.94765  1.000 39.42484  ? 250 LEU A HD21 1 
ATOM   3824 H HD22 . LEU A 1 250 ? -20.35460 -15.38122 34.47639  1.000 39.42484  ? 250 LEU A HD22 1 
ATOM   3825 H HD23 . LEU A 1 250 ? -20.66705 -16.86518 34.00336  1.000 39.42484  ? 250 LEU A HD23 1 
ATOM   3826 N N    . GLY A 1 251 ? -24.15214 -17.73115 38.23220  1.000 35.07578  ? 251 GLY A N    1 
ATOM   3827 C CA   . GLY A 1 251 ? -24.38824 -17.69558 39.65494  1.000 38.06514  ? 251 GLY A CA   1 
ATOM   3828 C C    . GLY A 1 251 ? -23.24583 -18.28057 40.45816  1.000 37.76820  ? 251 GLY A C    1 
ATOM   3829 O O    . GLY A 1 251 ? -22.66635 -17.61912 41.32543  1.000 39.22523  ? 251 GLY A O    1 
ATOM   3830 H H    . GLY A 1 251 ? -24.76071 -18.14929 37.79128  1.000 42.07799  ? 251 GLY A H    1 
ATOM   3831 H HA2  . GLY A 1 251 ? -24.51512 -16.77535 39.93419  1.000 45.66521  ? 251 GLY A HA2  1 
ATOM   3832 H HA3  . GLY A 1 251 ? -25.19117 -18.20068 39.85763  1.000 45.66521  ? 251 GLY A HA3  1 
ATOM   3833 N N    . PRO A 1 252 ? -22.90464 -19.54443 40.19438  1.000 38.23961  ? 252 PRO A N    1 
ATOM   3834 C CA   . PRO A 1 252 ? -21.81221 -20.16732 40.96063  1.000 41.39827  ? 252 PRO A CA   1 
ATOM   3835 C C    . PRO A 1 252 ? -20.49972 -19.41222 40.84977  1.000 40.10130  ? 252 PRO A C    1 
ATOM   3836 O O    . PRO A 1 252 ? -19.77639 -19.29130 41.84618  1.000 42.63539  ? 252 PRO A O    1 
ATOM   3837 C CB   . PRO A 1 252 ? -21.72530 -21.57703 40.35677  1.000 42.61882  ? 252 PRO A CB   1 
ATOM   3838 C CG   . PRO A 1 252 ? -23.08247 -21.82640 39.78778  1.000 40.40519  ? 252 PRO A CG   1 
ATOM   3839 C CD   . PRO A 1 252 ? -23.54473 -20.49811 39.27124  1.000 39.69011  ? 252 PRO A CD   1 
ATOM   3840 H HA   . PRO A 1 252 ? -22.05987 -20.23789 41.89582  1.000 49.66498  ? 252 PRO A HA   1 
ATOM   3841 H HB2  . PRO A 1 252 ? -21.04707 -21.59990 39.66367  1.000 51.12963  ? 252 PRO A HB2  1 
ATOM   3842 H HB3  . PRO A 1 252 ? -21.51369 -22.22227 41.04943  1.000 51.12963  ? 252 PRO A HB3  1 
ATOM   3843 H HG2  . PRO A 1 252 ? -23.02426 -22.47538 39.06921  1.000 48.47328  ? 252 PRO A HG2  1 
ATOM   3844 H HG3  . PRO A 1 252 ? -23.67594 -22.15268 40.48222  1.000 48.47328  ? 252 PRO A HG3  1 
ATOM   3845 H HD2  . PRO A 1 252 ? -23.24177 -20.35575 38.36082  1.000 47.61518  ? 252 PRO A HD2  1 
ATOM   3846 H HD3  . PRO A 1 252 ? -24.51114 -20.42672 39.31429  1.000 47.61518  ? 252 PRO A HD3  1 
ATOM   3847 N N    . LEU A 1 253 ? -20.16684 -18.89869 39.66207  1.000 37.24962  ? 253 LEU A N    1 
ATOM   3848 C CA   . LEU A 1 253 ? -18.97493 -18.06712 39.53521  1.000 35.95814  ? 253 LEU A CA   1 
ATOM   3849 C C    . LEU A 1 253 ? -19.10781 -16.79747 40.36646  1.000 35.69571  ? 253 LEU A C    1 
ATOM   3850 O O    . LEU A 1 253 ? -18.13259 -16.33611 40.97210  1.000 35.18917  ? 253 LEU A O    1 
ATOM   3851 C CB   . LEU A 1 253 ? -18.72206 -17.72080 38.06714  1.000 36.21397  ? 253 LEU A CB   1 
ATOM   3852 C CG   . LEU A 1 253 ? -17.94006 -18.73831 37.23001  1.000 34.35773  ? 253 LEU A CG   1 
ATOM   3853 C CD1  . LEU A 1 253 ? -17.74479 -18.23096 35.80767  1.000 33.31339  ? 253 LEU A CD1  1 
ATOM   3854 C CD2  . LEU A 1 253 ? -16.59576 -19.04394 37.87378  1.000 36.81836  ? 253 LEU A CD2  1 
ATOM   3855 H H    . LEU A 1 253 ? -20.60598 -19.01542 38.93192  1.000 44.68659  ? 253 LEU A H    1 
ATOM   3856 H HA   . LEU A 1 253 ? -18.20900 -18.56699 39.85828  1.000 43.13682  ? 253 LEU A HA   1 
ATOM   3857 H HB2  . LEU A 1 253 ? -19.58339 -17.60438 37.63650  1.000 43.44380  ? 253 LEU A HB2  1 
ATOM   3858 H HB3  . LEU A 1 253 ? -18.22232 -16.88990 38.03949  1.000 43.44380  ? 253 LEU A HB3  1 
ATOM   3859 H HG   . LEU A 1 253 ? -18.44941 -19.56275 37.18799  1.000 41.21632  ? 253 LEU A HG   1 
ATOM   3860 H HD11 . LEU A 1 253 ? -17.55725 -18.98461 35.22651  1.000 39.96312  ? 253 LEU A HD11 1 
ATOM   3861 H HD12 . LEU A 1 253 ? -18.55517 -17.78348 35.51794  1.000 39.96312  ? 253 LEU A HD12 1 
ATOM   3862 H HD13 . LEU A 1 253 ? -17.00045 -17.60914 35.79358  1.000 39.96312  ? 253 LEU A HD13 1 
ATOM   3863 H HD21 . LEU A 1 253 ? -15.99725 -19.40276 37.20003  1.000 44.16907  ? 253 LEU A HD21 1 
ATOM   3864 H HD22 . LEU A 1 253 ? -16.22779 -18.22485 38.24065  1.000 44.16907  ? 253 LEU A HD22 1 
ATOM   3865 H HD23 . LEU A 1 253 ? -16.72517 -19.69452 38.58152  1.000 44.16907  ? 253 LEU A HD23 1 
ATOM   3866 N N    . SER A 1 254 ? -20.31162 -16.22109 40.41277  1.000 34.96463  ? 254 SER A N    1 
ATOM   3867 C CA   . SER A 1 254 ? -20.52331 -15.01859 41.21030  1.000 35.17260  ? 254 SER A CA   1 
ATOM   3868 C C    . SER A 1 254 ? -20.33122 -15.30035 42.69374  1.000 38.34920  ? 254 SER A C    1 
ATOM   3869 O O    . SER A 1 254 ? -19.81223 -14.45545 43.43232  1.000 38.28390  ? 254 SER A O    1 
ATOM   3870 C CB   . SER A 1 254 ? -21.92358 -14.46185 40.95452  1.000 36.50553  ? 254 SER A CB   1 
ATOM   3871 O OG   . SER A 1 254 ? -22.24655 -13.44843 41.88974  1.000 38.07351  ? 254 SER A OG   1 
ATOM   3872 H H    . SER A 1 254 ? -21.00971 -16.50360 39.99749  1.000 41.94460  ? 254 SER A H    1 
ATOM   3873 H HA   . SER A 1 254 ? -19.87509 -14.34865 40.94215  1.000 42.19417  ? 254 SER A HA   1 
ATOM   3874 H HB2  . SER A 1 254 ? -21.95501 -14.08697 40.06044  1.000 43.79369  ? 254 SER A HB2  1 
ATOM   3875 H HB3  . SER A 1 254 ? -22.56842 -15.18197 41.03517  1.000 43.79369  ? 254 SER A HB3  1 
ATOM   3876 H HG   . SER A 1 254 ? -21.65091 -12.85613 41.88870  1.000 45.67525  ? 254 SER A HG   1 
ATOM   3877 N N    . ALA A 1 255 ? -20.74802 -16.48162 43.14983  1.000 39.44639  ? 255 ALA A N    1 
ATOM   3878 C CA   . ALA A 1 255 ? -20.64121 -16.80963 44.56683  1.000 42.49914  ? 255 ALA A CA   1 
ATOM   3879 C C    . ALA A 1 255 ? -19.21892 -17.19786 44.94867  1.000 41.64360  ? 255 ALA A C    1 
ATOM   3880 O O    . ALA A 1 255 ? -18.75306 -16.85699 46.04104  1.000 42.69449  ? 255 ALA A O    1 
ATOM   3881 C CB   . ALA A 1 255 ? -21.60832 -17.93896 44.91419  1.000 44.80364  ? 255 ALA A CB   1 
ATOM   3882 H H    . ALA A 1 255 ? -21.09214 -17.10240 42.66422  1.000 47.32271  ? 255 ALA A H    1 
ATOM   3883 H HA   . ALA A 1 255 ? -20.88779 -16.02828 45.08605  1.000 50.98601  ? 255 ALA A HA   1 
ATOM   3884 H HB1  . ALA A 1 255 ? -21.53040 -18.14189 45.85952  1.000 53.75142  ? 255 ALA A HB1  1 
ATOM   3885 H HB2  . ALA A 1 255 ? -22.51286 -17.65397 44.71051  1.000 53.75142  ? 255 ALA A HB2  1 
ATOM   3886 H HB3  . ALA A 1 255 ? -21.38177 -18.72176 44.38807  1.000 53.75142  ? 255 ALA A HB3  1 
ATOM   3887 N N    . GLN A 1 256 ? -18.51660 -17.91346 44.06730  1.000 40.55244  ? 256 GLN A N    1 
ATOM   3888 C CA   . GLN A 1 256 ? -17.12788 -18.26001 44.34613  1.000 43.30921  ? 256 GLN A CA   1 
ATOM   3889 C C    . GLN A 1 256 ? -16.26374 -17.01609 44.49580  1.000 43.13723  ? 256 GLN A C    1 
ATOM   3890 O O    . GLN A 1 256 ? -15.25835 -17.04205 45.21588  1.000 46.73204  ? 256 GLN A O    1 
ATOM   3891 C CB   . GLN A 1 256 ? -16.57816 -19.15883 43.23597  1.000 42.71129  ? 256 GLN A CB   1 
ATOM   3892 C CG   . GLN A 1 256 ? -15.07825 -19.40511 43.31524  1.000 47.63757  ? 256 GLN A CG   1 
ATOM   3893 C CD   . GLN A 1 256 ? -14.59925 -20.44849 42.32259  1.000 54.27315  ? 256 GLN A CD   1 
ATOM   3894 O OE1  . GLN A 1 256 ? -15.31674 -20.81819 41.39091  1.000 57.86926  ? 256 GLN A OE1  1 
ATOM   3895 N NE2  . GLN A 1 256 ? -13.37945 -20.93155 42.52037  1.000 57.32319  ? 256 GLN A NE2  1 
ATOM   3896 H H    . GLN A 1 256 ? -18.81683 -18.20397 43.31559  1.000 48.64997  ? 256 GLN A H    1 
ATOM   3897 H HA   . GLN A 1 256 ? -17.08942 -18.75556 45.17910  1.000 51.95810  ? 256 GLN A HA   1 
ATOM   3898 H HB2  . GLN A 1 256 ? -17.02061 -20.02051 43.28746  1.000 51.24060  ? 256 GLN A HB2  1 
ATOM   3899 H HB3  . GLN A 1 256 ? -16.76269 -18.74177 42.37987  1.000 51.24060  ? 256 GLN A HB3  1 
ATOM   3900 H HG2  . GLN A 1 256 ? -14.61169 -18.57583 43.12675  1.000 57.15213  ? 256 GLN A HG2  1 
ATOM   3901 H HG3  . GLN A 1 256 ? -14.85591 -19.71558 44.20691  1.000 57.15213  ? 256 GLN A HG3  1 
ATOM   3902 H HE21 . GLN A 1 256 ? -12.90800 -20.65097 43.18266  1.000 68.77488  ? 256 GLN A HE21 1 
ATOM   3903 H HE22 . GLN A 1 256 ? -13.06024 -21.52523 41.98629  1.000 68.77488  ? 256 GLN A HE22 1 
ATOM   3904 N N    . THR A 1 257 ? -16.63879 -15.92060 43.83526  1.000 41.92289  ? 257 THR A N    1 
ATOM   3905 C CA   . THR A 1 257 ? -15.83371 -14.70721 43.82408  1.000 40.08312  ? 257 THR A CA   1 
ATOM   3906 C C    . THR A 1 257 ? -16.38786 -13.59837 44.70816  1.000 39.08767  ? 257 THR A C    1 
ATOM   3907 O O    . THR A 1 257 ? -15.67399 -12.62291 44.96277  1.000 40.99701  ? 257 THR A O    1 
ATOM   3908 C CB   . THR A 1 257 ? -15.70151 -14.17356 42.39118  1.000 36.64825  ? 257 THR A CB   1 
ATOM   3909 O OG1  . THR A 1 257 ? -17.00444 -13.99613 41.82243  1.000 38.05698  ? 257 THR A OG1  1 
ATOM   3910 C CG2  . THR A 1 257 ? -14.90220 -15.13769 41.53440  1.000 37.42897  ? 257 THR A CG2  1 
ATOM   3911 H H    . THR A 1 257 ? -17.36618 -15.85786 43.38075  1.000 50.29452  ? 257 THR A H    1 
ATOM   3912 H HA   . THR A 1 257 ? -14.94856 -14.93151 44.15134  1.000 48.08680  ? 257 THR A HA   1 
ATOM   3913 H HB   . THR A 1 257 ? -15.23724 -13.32199 42.40447  1.000 43.96495  ? 257 THR A HB   1 
ATOM   3914 H HG1  . THR A 1 257 ? -17.41750 -14.72754 41.81682  1.000 45.65542  ? 257 THR A HG1  1 
ATOM   3915 H HG21 . THR A 1 257 ? -15.47148 -15.52427 40.85075  1.000 44.90181  ? 257 THR A HG21 1 
ATOM   3916 H HG22 . THR A 1 257 ? -14.16827 -14.67034 41.10564  1.000 44.90181  ? 257 THR A HG22 1 
ATOM   3917 H HG23 . THR A 1 257 ? -14.54257 -15.85084 42.08485  1.000 44.90181  ? 257 THR A HG23 1 
ATOM   3918 N N    . GLY A 1 258 ? -17.62865 -13.71394 45.17473  1.000 36.69365  ? 258 GLY A N    1 
ATOM   3919 C CA   . GLY A 1 258 ? -18.22944 -12.63878 45.93412  1.000 33.87109  ? 258 GLY A CA   1 
ATOM   3920 C C    . GLY A 1 258 ? -18.49878 -11.38383 45.13843  1.000 35.44464  ? 258 GLY A C    1 
ATOM   3921 O O    . GLY A 1 258 ? -18.60392 -10.30337 45.72321  1.000 35.69512  ? 258 GLY A O    1 
ATOM   3922 H H    . GLY A 1 258 ? -18.13421 -14.40065 45.06317  1.000 44.01942  ? 258 GLY A H    1 
ATOM   3923 H HA2  . GLY A 1 258 ? -19.07427 -12.94748 46.29728  1.000 40.63236  ? 258 GLY A HA2  1 
ATOM   3924 H HA3  . GLY A 1 258 ? -17.63750 -12.40520 46.66621  1.000 40.63236  ? 258 GLY A HA3  1 
ATOM   3925 N N    . ILE A 1 259 ? -18.61267 -11.49326 43.81573  1.000 34.89250  ? 259 ILE A N    1 
ATOM   3926 C CA   . ILE A 1 259 ? -18.88713 -10.35949 42.93994  1.000 33.66974  ? 259 ILE A CA   1 
ATOM   3927 C C    . ILE A 1 259 ? -20.22940 -10.60989 42.27155  1.000 33.30392  ? 259 ILE A C    1 
ATOM   3928 O O    . ILE A 1 259 ? -20.36812 -11.54791 41.47562  1.000 32.96524  ? 259 ILE A O    1 
ATOM   3929 C CB   . ILE A 1 259 ? -17.78996 -10.15735 41.88823  1.000 32.11175  ? 259 ILE A CB   1 
ATOM   3930 C CG1  . ILE A 1 259 ? -16.43796 -9.92715  42.56028  1.000 30.85901  ? 259 ILE A CG1  1 
ATOM   3931 C CG2  . ILE A 1 259 ? -18.14732 -8.97736  40.98148  1.000 33.73632  ? 259 ILE A CG2  1 
ATOM   3932 C CD1  . ILE A 1 259 ? -15.26848 -10.01892 41.60853  1.000 34.29970  ? 259 ILE A CD1  1 
ATOM   3933 H H    . ILE A 1 259 ? -18.53219 -12.23721 43.39187  1.000 41.85804  ? 259 ILE A H    1 
ATOM   3934 H HA   . ILE A 1 259 ? -18.95215 -9.55520  43.47826  1.000 40.39073  ? 259 ILE A HA   1 
ATOM   3935 H HB   . ILE A 1 259 ? -17.72657 -10.96097 41.34872  1.000 38.52114  ? 259 ILE A HB   1 
ATOM   3936 H HG12 . ILE A 1 259 ? -16.43140 -9.04086  42.95443  1.000 37.01785  ? 259 ILE A HG12 1 
ATOM   3937 H HG13 . ILE A 1 259 ? -16.31315 -10.59783 43.24985  1.000 37.01785  ? 259 ILE A HG13 1 
ATOM   3938 H HG21 . ILE A 1 259 ? -17.34933 -8.68578  40.51341  1.000 40.47063  ? 259 ILE A HG21 1 
ATOM   3939 H HG22 . ILE A 1 259 ? -18.81985 -9.26202  40.34307  1.000 40.47063  ? 259 ILE A HG22 1 
ATOM   3940 H HG23 . ILE A 1 259 ? -18.49400 -8.25383  41.52665  1.000 40.47063  ? 259 ILE A HG23 1 
ATOM   3941 H HD11 . ILE A 1 259 ? -15.13675 -9.15580  41.18594  1.000 41.14669  ? 259 ILE A HD11 1 
ATOM   3942 H HD12 . ILE A 1 259 ? -14.47444 -10.26780 42.10698  1.000 41.14669  ? 259 ILE A HD12 1 
ATOM   3943 H HD13 . ILE A 1 259 ? -15.46079 -10.69070 40.93576  1.000 41.14669  ? 259 ILE A HD13 1 
ATOM   3944 N N    . ALA A 1 260 ? -21.21418 -9.77230  42.58572  1.000 31.24239  ? 260 ALA A N    1 
ATOM   3945 C CA   . ALA A 1 260 ? -22.51342 -9.87679  41.93795  1.000 32.45786  ? 260 ALA A CA   1 
ATOM   3946 C C    . ALA A 1 260 ? -22.35846 -9.79036  40.42331  1.000 30.34261  ? 260 ALA A C    1 
ATOM   3947 O O    . ALA A 1 260 ? -21.51685 -9.04877  39.90771  1.000 27.26614  ? 260 ALA A O    1 
ATOM   3948 C CB   . ALA A 1 260 ? -23.44282 -8.77083  42.43554  1.000 33.46465  ? 260 ALA A CB   1 
ATOM   3949 H H    . ALA A 1 260 ? -21.15474 -9.14044  43.16608  1.000 37.47791  ? 260 ALA A H    1 
ATOM   3950 H HA   . ALA A 1 260 ? -22.91643 -10.73135 42.15749  1.000 38.93648  ? 260 ALA A HA   1 
ATOM   3951 H HB1  . ALA A 1 260 ? -24.28657 -8.82995  41.96068  1.000 40.14462  ? 260 ALA A HB1  1 
ATOM   3952 H HB2  . ALA A 1 260 ? -23.59008 -8.88650  43.38729  1.000 40.14462  ? 260 ALA A HB2  1 
ATOM   3953 H HB3  . ALA A 1 260 ? -23.02809 -7.91027  42.26717  1.000 40.14462  ? 260 ALA A HB3  1 
ATOM   3954 N N    . VAL A 1 261 ? -23.18312 -10.55829 39.70967  1.000 29.90546  ? 261 VAL A N    1 
ATOM   3955 C CA   . VAL A 1 261 ? -23.12129 -10.56163 38.25074  1.000 29.62417  ? 261 VAL A CA   1 
ATOM   3956 C C    . VAL A 1 261 ? -23.27255 -9.14917  37.70392  1.000 27.22902  ? 261 VAL A C    1 
ATOM   3957 O O    . VAL A 1 261 ? -22.55978 -8.74981  36.77627  1.000 26.16625  ? 261 VAL A O    1 
ATOM   3958 C CB   . VAL A 1 261 ? -24.19416 -11.50286 37.67242  1.000 30.86313  ? 261 VAL A CB   1 
ATOM   3959 C CG1  . VAL A 1 261 ? -24.33666 -11.28552 36.16925  1.000 29.20940  ? 261 VAL A CG1  1 
ATOM   3960 C CG2  . VAL A 1 261 ? -23.85083 -12.95468 37.99028  1.000 33.08544  ? 261 VAL A CG2  1 
ATOM   3961 H H    . VAL A 1 261 ? -23.78018 -11.08006 40.04264  1.000 35.87360  ? 261 VAL A H    1 
ATOM   3962 H HA   . VAL A 1 261 ? -22.24982 -10.89421 37.98462  1.000 35.53606  ? 261 VAL A HA   1 
ATOM   3963 H HB   . VAL A 1 261 ? -25.05039 -11.30354 38.08237  1.000 37.02280  ? 261 VAL A HB   1 
ATOM   3964 H HG11 . VAL A 1 261 ? -23.46312 -11.09379 35.79368  1.000 35.03833  ? 261 VAL A HG11 1 
ATOM   3965 H HG12 . VAL A 1 261 ? -24.70041 -12.08974 35.76697  1.000 35.03833  ? 261 VAL A HG12 1 
ATOM   3966 H HG13 . VAL A 1 261 ? -24.93496 -10.53807 36.01355  1.000 35.03833  ? 261 VAL A HG13 1 
ATOM   3967 H HG21 . VAL A 1 261 ? -23.00203 -12.98315 38.45893  1.000 39.68957  ? 261 VAL A HG21 1 
ATOM   3968 H HG22 . VAL A 1 261 ? -24.54976 -13.32949 38.54877  1.000 39.68957  ? 261 VAL A HG22 1 
ATOM   3969 H HG23 . VAL A 1 261 ? -23.78745 -13.45314 37.16057  1.000 39.68957  ? 261 VAL A HG23 1 
ATOM   3970 N N    . LEU A 1 262 ? -24.20485 -8.37232  38.26418  1.000 27.70182  ? 262 LEU A N    1 
ATOM   3971 C CA   . LEU A 1 262 ? -24.44364 -7.02547  37.75392  1.000 28.17477  ? 262 LEU A CA   1 
ATOM   3972 C C    . LEU A 1 262 ? -23.28237 -6.08890  38.06442  1.000 28.25892  ? 262 LEU A C    1 
ATOM   3973 O O    . LEU A 1 262 ? -23.01936 -5.15796  37.29400  1.000 27.27022  ? 262 LEU A O    1 
ATOM   3974 C CB   . LEU A 1 262 ? -25.74618 -6.47078  38.32709  1.000 30.55802  ? 262 LEU A CB   1 
ATOM   3975 C CG   . LEU A 1 262 ? -27.01581 -7.14740  37.81059  1.000 29.77274  ? 262 LEU A CG   1 
ATOM   3976 C CD1  . LEU A 1 262 ? -28.24173 -6.61767  38.53490  1.000 28.71590  ? 262 LEU A CD1  1 
ATOM   3977 C CD2  . LEU A 1 262 ? -27.15527 -6.95514  36.30027  1.000 30.64973  ? 262 LEU A CD2  1 
ATOM   3978 H H    . LEU A 1 262 ? -24.70220 -8.59895  38.92817  1.000 33.22924  ? 262 LEU A H    1 
ATOM   3979 H HA   . LEU A 1 262 ? -24.53727 -7.07054  36.78951  1.000 33.79677  ? 262 LEU A HA   1 
ATOM   3980 H HB2  . LEU A 1 262 ? -25.72840 -6.58011  39.29074  1.000 36.65667  ? 262 LEU A HB2  1 
ATOM   3981 H HB3  . LEU A 1 262 ? -25.80443 -5.52929  38.10103  1.000 36.65667  ? 262 LEU A HB3  1 
ATOM   3982 H HG   . LEU A 1 262 ? -26.95476 -8.09946  37.98598  1.000 35.71433  ? 262 LEU A HG   1 
ATOM   3983 H HD11 . LEU A 1 262 ? -28.99585 -7.19742  38.34491  1.000 34.44613  ? 262 LEU A HD11 1 
ATOM   3984 H HD12 . LEU A 1 262 ? -28.06491 -6.60676  39.48858  1.000 34.44613  ? 262 LEU A HD12 1 
ATOM   3985 H HD13 . LEU A 1 262 ? -28.42891 -5.71851  38.22287  1.000 34.44613  ? 262 LEU A HD13 1 
ATOM   3986 H HD21 . LEU A 1 262 ? -26.47934 -7.48599  35.85060  1.000 36.76672  ? 262 LEU A HD21 1 
ATOM   3987 H HD22 . LEU A 1 262 ? -28.03957 -7.24393  36.02549  1.000 36.76672  ? 262 LEU A HD22 1 
ATOM   3988 H HD23 . LEU A 1 262 ? -27.03332 -6.01635  36.08884  1.000 36.76672  ? 262 LEU A HD23 1 
ATOM   3989 N N    . ASP A 1 263 ? -22.58378 -6.30873  39.18146  1.000 26.22099  ? 263 ASP A N    1 
ATOM   3990 C CA   . ASP A 1 263 ? -21.35377 -5.56396  39.43021  1.000 29.59228  ? 263 ASP A CA   1 
ATOM   3991 C C    . ASP A 1 263 ? -20.32680 -5.85006  38.34042  1.000 28.72716  ? 263 ASP A C    1 
ATOM   3992 O O    . ASP A 1 263 ? -19.67281 -4.93244  37.82739  1.000 29.14514  ? 263 ASP A O    1 
ATOM   3993 C CB   . ASP A 1 263 ? -20.78314 -5.92034  40.80373  1.000 31.50189  ? 263 ASP A CB   1 
ATOM   3994 C CG   . ASP A 1 263 ? -21.67519 -5.47135  41.95107  1.000 32.62445  ? 263 ASP A CG   1 
ATOM   3995 O OD1  . ASP A 1 263 ? -22.79101 -4.97060  41.70371  1.000 30.50415  ? 263 ASP A OD1  1 
ATOM   3996 O OD2  . ASP A 1 263 ? -21.24995 -5.62226  43.11189  1.000 31.99418  ? 263 ASP A OD2  1 
ATOM   3997 H H    . ASP A 1 263 ? -22.79712 -6.87121  39.79604  1.000 31.45224  ? 263 ASP A H    1 
ATOM   3998 H HA   . ASP A 1 263 ? -21.55433 -4.61492  39.43050  1.000 35.49778  ? 263 ASP A HA   1 
ATOM   3999 H HB2  . ASP A 1 263 ? -20.68157 -6.88319  40.86290  1.000 37.78932  ? 263 ASP A HB2  1 
ATOM   4000 H HB3  . ASP A 1 263 ? -19.92083 -5.48870  40.90866  1.000 37.78932  ? 263 ASP A HB3  1 
ATOM   4001 N N    . MET A 1 264 ? -20.17429 -7.12253  37.97182  1.000 30.27732  ? 264 MET A N    1 
ATOM   4002 C CA   . MET A 1 264 ? -19.25392 -7.46939  36.89328  1.000 28.72271  ? 264 MET A CA   1 
ATOM   4003 C C    . MET A 1 264 ? -19.72289 -6.88420  35.56739  1.000 27.33958  ? 264 MET A C    1 
ATOM   4004 O O    . MET A 1 264 ? -18.90404 -6.45449  34.74828  1.000 31.61793  ? 264 MET A O    1 
ATOM   4005 C CB   . MET A 1 264 ? -19.10591 -8.98930  36.79553  1.000 31.01782  ? 264 MET A CB   1 
ATOM   4006 C CG   . MET A 1 264 ? -18.01051 -9.43397  35.83544  1.000 27.01969  ? 264 MET A CG   1 
ATOM   4007 S SD   . MET A 1 264 ? -16.36468 -9.01074  36.42799  1.000 30.80356  ? 264 MET A SD   1 
ATOM   4008 C CE   . MET A 1 264 ? -15.95756 -10.46179 37.39154  1.000 32.24118  ? 264 MET A CE   1 
ATOM   4009 H H    . MET A 1 264 ? -20.58467 -7.79120  38.32405  1.000 36.31983  ? 264 MET A H    1 
ATOM   4010 H HA   . MET A 1 264 ? -18.37924 -7.10538  37.10141  1.000 34.45430  ? 264 MET A HA   1 
ATOM   4011 H HB2  . MET A 1 264 ? -18.89082 -9.33950  37.67416  1.000 37.20843  ? 264 MET A HB2  1 
ATOM   4012 H HB3  . MET A 1 264 ? -19.94411 -9.36556  36.48449  1.000 37.20843  ? 264 MET A HB3  1 
ATOM   4013 H HG2  . MET A 1 264 ? -18.05392 -10.39709 35.72862  1.000 32.41068  ? 264 MET A HG2  1 
ATOM   4014 H HG3  . MET A 1 264 ? -18.14352 -8.99884  34.97878  1.000 32.41068  ? 264 MET A HG3  1 
ATOM   4015 H HE1  . MET A 1 264 ? -16.50007 -10.46938 38.19560  1.000 38.67647  ? 264 MET A HE1  1 
ATOM   4016 H HE2  . MET A 1 264 ? -16.13982 -11.25383 36.86205  1.000 38.67647  ? 264 MET A HE2  1 
ATOM   4017 H HE3  . MET A 1 264 ? -15.01716 -10.43070 37.62729  1.000 38.67647  ? 264 MET A HE3  1 
ATOM   4018 N N    . CYS A 1 265 ? -21.03872 -6.85877  35.33483  1.000 27.09162  ? 265 CYS A N    1 
ATOM   4019 C CA   . CYS A 1 265 ? -21.56398 -6.19431  34.14840  1.000 27.65594  ? 265 CYS A CA   1 
ATOM   4020 C C    . CYS A 1 265 ? -21.11975 -4.73900  34.10301  1.000 30.72171  ? 265 CYS A C    1 
ATOM   4021 O O    . CYS A 1 265 ? -20.70526 -4.23603  33.05031  1.000 29.30924  ? 265 CYS A O    1 
ATOM   4022 C CB   . CYS A 1 265 ? -23.08967 -6.28534  34.12643  1.000 26.66638  ? 265 CYS A CB   1 
ATOM   4023 S SG   . CYS A 1 265 ? -23.73074 -7.91228  33.67224  1.000 30.30780  ? 265 CYS A SG   1 
ATOM   4024 H H    . CYS A 1 265 ? -21.63602 -7.21364  35.84168  1.000 32.49699  ? 265 CYS A H    1 
ATOM   4025 H HA   . CYS A 1 265 ? -21.22542 -6.64458  33.35876  1.000 33.17417  ? 265 CYS A HA   1 
ATOM   4026 H HB2  . CYS A 1 265 ? -23.42524 -6.07380  35.01161  1.000 31.98670  ? 265 CYS A HB2  1 
ATOM   4027 H HB3  . CYS A 1 265 ? -23.42877 -5.64521  33.48134  1.000 31.98670  ? 265 CYS A HB3  1 
ATOM   4028 H HG   . CYS A 1 265 ? -24.92787 -7.85713  33.61030  1.000 36.35641  ? 265 CYS A HG   1 
ATOM   4029 N N    . ALA A 1 266 ? -21.19671 -4.04845  35.24178  1.000 29.17638  ? 266 ALA A N    1 
ATOM   4030 C CA   . ALA A 1 266 ? -20.73151 -2.66669  35.30877  1.000 31.62074  ? 266 ALA A CA   1 
ATOM   4031 C C    . ALA A 1 266 ? -19.27189 -2.55518  34.88849  1.000 31.69566  ? 266 ALA A C    1 
ATOM   4032 O O    . ALA A 1 266 ? -18.88088 -1.59076  34.22115  1.000 32.42710  ? 266 ALA A O    1 
ATOM   4033 C CB   . ALA A 1 266 ? -20.91703 -2.12418  36.72615  1.000 31.62294  ? 266 ALA A CB   1 
ATOM   4034 H H    . ALA A 1 266 ? -21.51099 -4.35439  35.98153  1.000 34.99871  ? 266 ALA A H    1 
ATOM   4035 H HA   . ALA A 1 266 ? -21.26322 -2.12775  34.70237  1.000 37.93193  ? 266 ALA A HA   1 
ATOM   4036 H HB1  . ALA A 1 266 ? -20.64132 -1.19443  36.74703  1.000 37.93457  ? 266 ALA A HB1  1 
ATOM   4037 H HB2  . ALA A 1 266 ? -21.85239 -2.19744  36.97242  1.000 37.93457  ? 266 ALA A HB2  1 
ATOM   4038 H HB3  . ALA A 1 266 ? -20.37235 -2.64452  37.33727  1.000 37.93457  ? 266 ALA A HB3  1 
ATOM   4039 N N    . SER A 1 267 ? -18.44951 -3.53168  35.27647  1.000 31.99046  ? 267 SER A N    1 
ATOM   4040 C CA   . SER A 1 267 ? -17.04078 -3.50458  34.89897  1.000 34.11392  ? 267 SER A CA   1 
ATOM   4041 C C    . SER A 1 267 ? -16.86776 -3.73052  33.40355  1.000 34.40431  ? 267 SER A C    1 
ATOM   4042 O O    . SER A 1 267 ? -16.01308 -3.09958  32.77059  1.000 34.05879  ? 267 SER A O    1 
ATOM   4043 C CB   . SER A 1 267 ? -16.26409 -4.55559  35.69096  1.000 33.53425  ? 267 SER A CB   1 
ATOM   4044 O OG   . SER A 1 267 ? -15.97524 -4.09871  36.99939  1.000 35.63035  ? 267 SER A OG   1 
ATOM   4045 H H    . SER A 1 267 ? -18.68017 -4.21037  35.75163  1.000 38.37560  ? 267 SER A H    1 
ATOM   4046 H HA   . SER A 1 267 ? -16.67605 -2.63283  35.11790  1.000 40.92375  ? 267 SER A HA   1 
ATOM   4047 H HB2  . SER A 1 267 ? -16.79845 -5.36294  35.75051  1.000 40.22814  ? 267 SER A HB2  1 
ATOM   4048 H HB3  . SER A 1 267 ? -15.43032 -4.74270  35.23191  1.000 40.22814  ? 267 SER A HB3  1 
ATOM   4049 H HG   . SER A 1 267 ? -15.32360 -3.56896  36.98140  1.000 42.74346  ? 267 SER A HG   1 
ATOM   4050 N N    . LEU A 1 268 ? -17.66249 -4.63384  32.82540  1.000 30.50657  ? 268 LEU A N    1 
ATOM   4051 C CA   . LEU A 1 268 ? -17.59198 -4.87119  31.38726  1.000 34.54466  ? 268 LEU A CA   1 
ATOM   4052 C C    . LEU A 1 268 ? -18.01149 -3.63047  30.61182  1.000 32.71394  ? 268 LEU A C    1 
ATOM   4053 O O    . LEU A 1 268 ? -17.38744 -3.27194  29.60622  1.000 32.74350  ? 268 LEU A O    1 
ATOM   4054 C CB   . LEU A 1 268 ? -18.47519 -6.06746  31.02438  1.000 31.61240  ? 268 LEU A CB   1 
ATOM   4055 C CG   . LEU A 1 268 ? -18.64864 -6.43458  29.55082  1.000 28.76157  ? 268 LEU A CG   1 
ATOM   4056 C CD1  . LEU A 1 268 ? -17.32205 -6.43427  28.83097  1.000 32.99590  ? 268 LEU A CD1  1 
ATOM   4057 C CD2  . LEU A 1 268 ? -19.31334 -7.79976  29.43768  1.000 29.72032  ? 268 LEU A CD2  1 
ATOM   4058 H H    . LEU A 1 268 ? -18.24279 -5.11527  33.23902  1.000 36.59493  ? 268 LEU A H    1 
ATOM   4059 H HA   . LEU A 1 268 ? -16.67919 -5.08343  31.13691  1.000 41.44064  ? 268 LEU A HA   1 
ATOM   4060 H HB2  . LEU A 1 268 ? -18.10071 -6.84891  31.46027  1.000 37.92193  ? 268 LEU A HB2  1 
ATOM   4061 H HB3  . LEU A 1 268 ? -19.36385 -5.88886  31.36976  1.000 37.92193  ? 268 LEU A HB3  1 
ATOM   4062 H HG   . LEU A 1 268 ? -19.21309 -5.77211  29.12254  1.000 34.50092  ? 268 LEU A HG   1 
ATOM   4063 H HD11 . LEU A 1 268 ? -16.67183 -6.91479  29.36689  1.000 39.58213  ? 268 LEU A HD11 1 
ATOM   4064 H HD12 . LEU A 1 268 ? -17.42919 -6.87041  27.97120  1.000 39.58213  ? 268 LEU A HD12 1 
ATOM   4065 H HD13 . LEU A 1 268 ? -17.03243 -5.51741  28.70296  1.000 39.58213  ? 268 LEU A HD13 1 
ATOM   4066 H HD21 . LEU A 1 268 ? -19.45169 -8.00693  28.50022  1.000 35.65143  ? 268 LEU A HD21 1 
ATOM   4067 H HD22 . LEU A 1 268 ? -18.73636 -8.46642  29.84211  1.000 35.65143  ? 268 LEU A HD22 1 
ATOM   4068 H HD23 . LEU A 1 268 ? -20.16555 -7.77538  29.90032  1.000 35.65143  ? 268 LEU A HD23 1 
ATOM   4069 N N    . LYS A 1 269 ? -19.06245 -2.95574  31.07826  1.000 34.74665  ? 269 LYS A N    1 
ATOM   4070 C CA   . LYS A 1 269 ? -19.55835 -1.75815  30.40616  1.000 37.55161  ? 269 LYS A CA   1 
ATOM   4071 C C    . LYS A 1 269 ? -18.46928 -0.69662  30.28802  1.000 37.74971  ? 269 LYS A C    1 
ATOM   4072 O O    . LYS A 1 269 ? -18.28214 -0.09808  29.22340  1.000 34.50321  ? 269 LYS A O    1 
ATOM   4073 C CB   . LYS A 1 269 ? -20.77143 -1.23002  31.17437  1.000 36.72999  ? 269 LYS A CB   1 
ATOM   4074 C CG   . LYS A 1 269 ? -21.36867 0.07555   30.68549  1.000 43.88674  ? 269 LYS A CG   1 
ATOM   4075 C CD   . LYS A 1 269 ? -22.66974 0.34899   31.44044  1.000 51.00042  ? 269 LYS A CD   1 
ATOM   4076 C CE   . LYS A 1 269 ? -22.74868 1.76820   31.97687  1.000 50.24409  ? 269 LYS A CE   1 
ATOM   4077 N NZ   . LYS A 1 269 ? -24.00591 1.98401   32.75505  1.000 48.38029  ? 269 LYS A NZ   1 
ATOM   4078 H H    . LYS A 1 269 ? -19.50630 -3.17091  31.78275  1.000 41.68303  ? 269 LYS A H    1 
ATOM   4079 H HA   . LYS A 1 269 ? -19.83656 -1.98011  29.50381  1.000 45.04897  ? 269 LYS A HA   1 
ATOM   4080 H HB2  . LYS A 1 269 ? -21.47246 -1.89868  31.12604  1.000 44.06303  ? 269 LYS A HB2  1 
ATOM   4081 H HB3  . LYS A 1 269 ? -20.50660 -1.09311  32.09742  1.000 44.06303  ? 269 LYS A HB3  1 
ATOM   4082 H HG2  . LYS A 1 269 ? -20.74996 0.80390   30.85164  1.000 52.65113  ? 269 LYS A HG2  1 
ATOM   4083 H HG3  . LYS A 1 269 ? -21.56256 0.01479   29.73701  1.000 52.65113  ? 269 LYS A HG3  1 
ATOM   4084 H HD2  . LYS A 1 269 ? -23.41910 0.21343   30.83962  1.000 61.18755  ? 269 LYS A HD2  1 
ATOM   4085 H HD3  . LYS A 1 269 ? -22.73339 -0.25991  32.19282  1.000 61.18755  ? 269 LYS A HD3  1 
ATOM   4086 H HE2  . LYS A 1 269 ? -21.99371 1.93338   32.56307  1.000 60.27996  ? 269 LYS A HE2  1 
ATOM   4087 H HE3  . LYS A 1 269 ? -22.73630 2.39380   31.23567  1.000 60.27996  ? 269 LYS A HE3  1 
ATOM   4088 H HZ1  . LYS A 1 269 ? -24.21867 1.24382   33.20109  1.000 58.04340  ? 269 LYS A HZ1  1 
ATOM   4089 H HZ2  . LYS A 1 269 ? -23.89406 2.64910   33.33579  1.000 58.04340  ? 269 LYS A HZ2  1 
ATOM   4090 H HZ3  . LYS A 1 269 ? -24.67332 2.19101   32.20387  1.000 58.04340  ? 269 LYS A HZ3  1 
ATOM   4091 N N    . GLU A 1 270 ? -17.73472 -0.45097  31.37516  1.000 38.34522  ? 270 GLU A N    1 
ATOM   4092 C CA   . GLU A 1 270 ? -16.67532 0.55016   31.32946  1.000 39.88355  ? 270 GLU A CA   1 
ATOM   4093 C C    . GLU A 1 270 ? -15.49937 0.08313   30.48112  1.000 39.60295  ? 270 GLU A C    1 
ATOM   4094 O O    . GLU A 1 270 ? -14.79537 0.91236   29.89743  1.000 39.71901  ? 270 GLU A O    1 
ATOM   4095 C CB   . GLU A 1 270 ? -16.20763 0.88854   32.74468  1.000 42.69759  ? 270 GLU A CB   1 
ATOM   4096 C CG   . GLU A 1 270 ? -17.31500 1.40529   33.65398  1.000 46.59662  ? 270 GLU A CG   1 
ATOM   4097 C CD   . GLU A 1 270 ? -17.95851 2.68036   33.13559  1.000 55.96832  ? 270 GLU A CD   1 
ATOM   4098 O OE1  . GLU A 1 270 ? -17.22383 3.57145   32.65708  1.000 62.76387  ? 270 GLU A OE1  1 
ATOM   4099 O OE2  . GLU A 1 270 ? -19.20217 2.78713   33.20135  1.000 52.26718  ? 270 GLU A OE2  1 
ATOM   4100 H H    . GLU A 1 270 ? -17.82912 -0.84304  32.13474  1.000 46.00131  ? 270 GLU A H    1 
ATOM   4101 H HA   . GLU A 1 270 ? -17.03024 1.36031   30.93122  1.000 47.84731  ? 270 GLU A HA   1 
ATOM   4102 H HB2  . GLU A 1 270 ? -15.84119 0.08766   33.15114  1.000 51.22415  ? 270 GLU A HB2  1 
ATOM   4103 H HB3  . GLU A 1 270 ? -15.52486 1.57545   32.69087  1.000 51.22415  ? 270 GLU A HB3  1 
ATOM   4104 H HG2  . GLU A 1 270 ? -18.00632 0.72862   33.72527  1.000 55.90299  ? 270 GLU A HG2  1 
ATOM   4105 H HG3  . GLU A 1 270 ? -16.94252 1.59260   34.52981  1.000 55.90299  ? 270 GLU A HG3  1 
ATOM   4106 N N    . LEU A 1 271 ? -15.26482 -1.22920  30.40084  1.000 36.59344  ? 271 LEU A N    1 
ATOM   4107 C CA   . LEU A 1 271 ? -14.21982 -1.72829  29.51151  1.000 37.33147  ? 271 LEU A CA   1 
ATOM   4108 C C    . LEU A 1 271 ? -14.60571 -1.52012  28.05290  1.000 34.95111  ? 271 LEU A C    1 
ATOM   4109 O O    . LEU A 1 271 ? -13.75166 -1.20231  27.21599  1.000 34.96678  ? 271 LEU A O    1 
ATOM   4110 C CB   . LEU A 1 271 ? -13.94912 -3.20742  29.78986  1.000 36.14156  ? 271 LEU A CB   1 
ATOM   4111 C CG   . LEU A 1 271 ? -13.03162 -3.55094  30.96582  1.000 36.42319  ? 271 LEU A CG   1 
ATOM   4112 C CD1  . LEU A 1 271 ? -13.15110 -5.03022  31.29837  1.000 38.27001  ? 271 LEU A CD1  1 
ATOM   4113 C CD2  . LEU A 1 271 ? -11.58437 -3.19693  30.66104  1.000 35.28999  ? 271 LEU A CD2  1 
ATOM   4114 H H    . LEU A 1 271 ? -15.68716 -1.83569  30.84061  1.000 43.89917  ? 271 LEU A H    1 
ATOM   4115 H HA   . LEU A 1 271 ? -13.39961 -1.24013  29.68431  1.000 44.78481  ? 271 LEU A HA   1 
ATOM   4116 H HB2  . LEU A 1 271 ? -14.80126 -3.63670  29.96444  1.000 43.35692  ? 271 LEU A HB2  1 
ATOM   4117 H HB3  . LEU A 1 271 ? -13.54211 -3.58848  28.99612  1.000 43.35692  ? 271 LEU A HB3  1 
ATOM   4118 H HG   . LEU A 1 271 ? -13.30378 -3.02896  31.73677  1.000 43.69487  ? 271 LEU A HG   1 
ATOM   4119 H HD11 . LEU A 1 271 ? -12.45340 -5.26966  31.92829  1.000 45.91106  ? 271 LEU A HD11 1 
ATOM   4120 H HD12 . LEU A 1 271 ? -14.02242 -5.19627  31.69098  1.000 45.91106  ? 271 LEU A HD12 1 
ATOM   4121 H HD13 . LEU A 1 271 ? -13.05192 -5.54622  30.48302  1.000 45.91106  ? 271 LEU A HD13 1 
ATOM   4122 H HD21 . LEU A 1 271 ? -11.13601 -2.96109  31.48824  1.000 42.33504  ? 271 LEU A HD21 1 
ATOM   4123 H HD22 . LEU A 1 271 ? -11.15006 -3.96414  30.25649  1.000 42.33504  ? 271 LEU A HD22 1 
ATOM   4124 H HD23 . LEU A 1 271 ? -11.56544 -2.44502  30.04853  1.000 42.33504  ? 271 LEU A HD23 1 
ATOM   4125 N N    . LEU A 1 272 ? -15.89125 -1.68863  27.73218  1.000 33.47253  ? 272 LEU A N    1 
ATOM   4126 C CA   . LEU A 1 272 ? -16.35488 -1.42231  26.37494  1.000 35.23317  ? 272 LEU A CA   1 
ATOM   4127 C C    . LEU A 1 272 ? -16.29280 0.06434   26.05723  1.000 35.51415  ? 272 LEU A C    1 
ATOM   4128 O O    . LEU A 1 272 ? -15.87097 0.45423   24.96332  1.000 34.84668  ? 272 LEU A O    1 
ATOM   4129 C CB   . LEU A 1 272 ? -17.78212 -1.93646  26.19445  1.000 31.94209  ? 272 LEU A CB   1 
ATOM   4130 C CG   . LEU A 1 272 ? -17.96291 -3.44734  26.29680  1.000 33.01565  ? 272 LEU A CG   1 
ATOM   4131 C CD1  . LEU A 1 272 ? -19.43466 -3.82595  26.20431  1.000 31.93197  ? 272 LEU A CD1  1 
ATOM   4132 C CD2  . LEU A 1 272 ? -17.15910 -4.14188  25.21596  1.000 31.99264  ? 272 LEU A CD2  1 
ATOM   4133 H H    . LEU A 1 272 ? -16.50403 -1.95222  28.27498  1.000 40.15409  ? 272 LEU A H    1 
ATOM   4134 H HA   . LEU A 1 272 ? -15.78025 -1.89571  25.75316  1.000 42.26685  ? 272 LEU A HA   1 
ATOM   4135 H HB2  . LEU A 1 272 ? -18.33830 -1.53303  26.87915  1.000 38.31755  ? 272 LEU A HB2  1 
ATOM   4136 H HB3  . LEU A 1 272 ? -18.09171 -1.66850  25.31510  1.000 38.31755  ? 272 LEU A HB3  1 
ATOM   4137 H HG   . LEU A 1 272 ? -17.63837 -3.74857  27.15984  1.000 39.60583  ? 272 LEU A HG   1 
ATOM   4138 H HD11 . LEU A 1 272 ? -19.81618 -3.41895  25.41078  1.000 38.30541  ? 272 LEU A HD11 1 
ATOM   4139 H HD12 . LEU A 1 272 ? -19.50950 -4.79150  26.14940  1.000 38.30541  ? 272 LEU A HD12 1 
ATOM   4140 H HD13 . LEU A 1 272 ? -19.89412 -3.50302  26.99520  1.000 38.30541  ? 272 LEU A HD13 1 
ATOM   4141 H HD21 . LEU A 1 272 ? -17.36087 -3.73249  24.36005  1.000 38.37821  ? 272 LEU A HD21 1 
ATOM   4142 H HD22 . LEU A 1 272 ? -16.21441 -4.04589  25.41405  1.000 38.37821  ? 272 LEU A HD22 1 
ATOM   4143 H HD23 . LEU A 1 272 ? -17.39953 -5.08144  25.19811  1.000 38.37821  ? 272 LEU A HD23 1 
ATOM   4144 N N    . GLN A 1 273 ? -16.71036 0.90923   27.00135  1.000 35.79270  ? 273 GLN A N    1 
ATOM   4145 C CA   . GLN A 1 273 ? -16.79635 2.33901   26.73126  1.000 37.01843  ? 273 GLN A CA   1 
ATOM   4146 C C    . GLN A 1 273 ? -15.42709 3.00839   26.72942  1.000 37.12651  ? 273 GLN A C    1 
ATOM   4147 O O    . GLN A 1 273 ? -15.24776 4.03978   26.07048  1.000 35.79853  ? 273 GLN A O    1 
ATOM   4148 C CB   . GLN A 1 273 ? -17.70494 3.00892   27.76423  1.000 41.18399  ? 273 GLN A CB   1 
ATOM   4149 C CG   . GLN A 1 273 ? -19.16724 2.59267   27.67713  1.000 41.92601  ? 273 GLN A CG   1 
ATOM   4150 C CD   . GLN A 1 273 ? -20.02223 3.21129   28.76959  1.000 50.08800  ? 273 GLN A CD   1 
ATOM   4151 O OE1  . GLN A 1 273 ? -19.60834 3.30323   29.92790  1.000 51.06758  ? 273 GLN A OE1  1 
ATOM   4152 N NE2  . GLN A 1 273 ? -21.22233 3.64255   28.40287  1.000 51.45619  ? 273 GLN A NE2  1 
ATOM   4153 H H    . GLN A 1 273 ? -16.94633 0.68053   27.79609  1.000 42.93828  ? 273 GLN A H    1 
ATOM   4154 H HA   . GLN A 1 273 ? -17.18904 2.46706   25.85359  1.000 44.40916  ? 273 GLN A HA   1 
ATOM   4155 H HB2  . GLN A 1 273 ? -17.38666 2.77975   28.65140  1.000 49.40783  ? 273 GLN A HB2  1 
ATOM   4156 H HB3  . GLN A 1 273 ? -17.66479 3.96946   27.63521  1.000 49.40783  ? 273 GLN A HB3  1 
ATOM   4157 H HG2  . GLN A 1 273 ? -19.52532 2.87438   26.82079  1.000 50.29825  ? 273 GLN A HG2  1 
ATOM   4158 H HG3  . GLN A 1 273 ? -19.22652 1.62807   27.76039  1.000 50.29825  ? 273 GLN A HG3  1 
ATOM   4159 H HE21 . GLN A 1 273 ? -21.47625 3.56353   27.58502  1.000 61.73448  ? 273 GLN A HE21 1 
ATOM   4160 H HE22 . GLN A 1 273 ? -21.74622 4.00108   28.98304  1.000 61.73448  ? 273 GLN A HE22 1 
ATOM   4161 N N    . ASN A 1 274 ? -14.45203 2.44299   27.44468  1.000 35.12903  ? 274 ASN A N    1 
ATOM   4162 C CA   . ASN A 1 274 ? -13.15491 3.07895   27.61125  1.000 36.10245  ? 274 ASN A CA   1 
ATOM   4163 C C    . ASN A 1 274 ? -11.97864 2.25462   27.10704  1.000 36.48763  ? 274 ASN A C    1 
ATOM   4164 O O    . ASN A 1 274 ? -10.86032 2.77852   27.06296  1.000 36.92101  ? 274 ASN A O    1 
ATOM   4165 C CB   . ASN A 1 274 ? -12.91572 3.41207   29.09243  1.000 36.27234  ? 274 ASN A CB   1 
ATOM   4166 C CG   . ASN A 1 274 ? -14.11724 4.06908   29.74168  1.000 42.50738  ? 274 ASN A CG   1 
ATOM   4167 O OD1  . ASN A 1 274 ? -14.56542 3.64931   30.81026  1.000 48.95239  ? 274 ASN A OD1  1 
ATOM   4168 N ND2  . ASN A 1 274 ? -14.65128 5.09929   29.09603  1.000 41.94720  ? 274 ASN A ND2  1 
ATOM   4169 H H    . ASN A 1 274 ? -14.52331 1.68490   27.84445  1.000 42.14189  ? 274 ASN A H    1 
ATOM   4170 H HA   . ASN A 1 274 ? -13.16207 3.90747   27.10688  1.000 43.30998  ? 274 ASN A HA   1 
ATOM   4171 H HB2  . ASN A 1 274 ? -12.72386 2.59255   29.57459  1.000 43.51385  ? 274 ASN A HB2  1 
ATOM   4172 H HB3  . ASN A 1 274 ? -12.16474 4.02197   29.16282  1.000 43.51385  ? 274 ASN A HB3  1 
ATOM   4173 H HD21 . ASN A 1 274 ? -15.33463 5.50518   29.42449  1.000 50.32369  ? 274 ASN A HD21 1 
ATOM   4174 H HD22 . ASN A 1 274 ? -14.31379 5.36059   28.34942  1.000 50.32369  ? 274 ASN A HD22 1 
ATOM   4175 N N    . GLY A 1 275 ? -12.18404 0.99799   26.73416  1.000 35.40396  ? 275 GLY A N    1 
ATOM   4176 C CA   . GLY A 1 275 ? -11.09180 0.17142   26.26620  1.000 37.03371  ? 275 GLY A CA   1 
ATOM   4177 C C    . GLY A 1 275 ? -10.22071 -0.33913  27.40055  1.000 37.87387  ? 275 GLY A C    1 
ATOM   4178 O O    . GLY A 1 275 ? -10.49322 -0.14124  28.58663  1.000 41.89433  ? 275 GLY A O    1 
ATOM   4179 H H    . GLY A 1 275 ? -12.94845 0.60406   26.74428  1.000 42.47179  ? 275 GLY A H    1 
ATOM   4180 H HA2  . GLY A 1 275 ? -11.45028 -0.59320  25.78895  1.000 44.42750  ? 275 GLY A HA2  1 
ATOM   4181 H HA3  . GLY A 1 275 ? -10.53502 0.68774   25.66262  1.000 44.42750  ? 275 GLY A HA3  1 
ATOM   4182 N N    . MET A 1 276 ? -9.14292  -1.01612  27.00938  1.000 37.38364  ? 276 MET A N    1 
ATOM   4183 C CA   . MET A 1 276 ? -8.21162  -1.60980  27.95695  1.000 38.60507  ? 276 MET A CA   1 
ATOM   4184 C C    . MET A 1 276 ? -7.07152  -0.67249  28.33795  1.000 41.42544  ? 276 MET A C    1 
ATOM   4185 O O    . MET A 1 276 ? -6.29272  -1.00880  29.23505  1.000 41.76300  ? 276 MET A O    1 
ATOM   4186 C CB   . MET A 1 276 ? -7.62165  -2.90479  27.37668  1.000 42.46192  ? 276 MET A CB   1 
ATOM   4187 C CG   . MET A 1 276 ? -8.64539  -3.87235  26.78525  1.000 41.52827  ? 276 MET A CG   1 
ATOM   4188 S SD   . MET A 1 276 ? -9.17644  -5.15319  27.93284  1.000 45.92337  ? 276 MET A SD   1 
ATOM   4189 C CE   . MET A 1 276 ? -7.77113  -6.26075  27.89254  1.000 39.44202  ? 276 MET A CE   1 
ATOM   4190 H H    . MET A 1 276 ? -8.92837  -1.14584  26.18674  1.000 44.84741  ? 276 MET A H    1 
ATOM   4191 H HA   . MET A 1 276 ? -8.70319  -1.84130  28.76048  1.000 46.31313  ? 276 MET A HA   1 
ATOM   4192 H HB2  . MET A 1 276 ? -7.00132  -2.66941  26.66909  1.000 50.94135  ? 276 MET A HB2  1 
ATOM   4193 H HB3  . MET A 1 276 ? -7.15400  -3.37364  28.08548  1.000 50.94135  ? 276 MET A HB3  1 
ATOM   4194 H HG2  . MET A 1 276 ? -9.43113  -3.37065  26.51728  1.000 49.82097  ? 276 MET A HG2  1 
ATOM   4195 H HG3  . MET A 1 276 ? -8.25241  -4.31023  26.01406  1.000 49.82097  ? 276 MET A HG3  1 
ATOM   4196 H HE1  . MET A 1 276 ? -7.60251  -6.58975  28.78932  1.000 47.31747  ? 276 MET A HE1  1 
ATOM   4197 H HE2  . MET A 1 276 ? -7.97052  -7.00249  27.30012  1.000 47.31747  ? 276 MET A HE2  1 
ATOM   4198 H HE3  . MET A 1 276 ? -6.99646  -5.77628  27.56683  1.000 47.31747  ? 276 MET A HE3  1 
ATOM   4199 N N    . ASN A 1 277 ? -6.95586  0.48566   27.68806  1.000 40.07112  ? 277 ASN A N    1 
ATOM   4200 C CA   . ASN A 1 277 ? -5.86582  1.42625   27.94679  1.000 41.39414  ? 277 ASN A CA   1 
ATOM   4201 C C    . ASN A 1 277 ? -4.50827  0.72898   27.90617  1.000 39.19479  ? 277 ASN A C    1 
ATOM   4202 O O    . ASN A 1 277 ? -3.61170  1.02395   28.69734  1.000 37.31505  ? 277 ASN A O    1 
ATOM   4203 C CB   . ASN A 1 277 ? -6.06082  2.14102   29.28623  1.000 41.95450  ? 277 ASN A CB   1 
ATOM   4204 C CG   . ASN A 1 277 ? -7.22648  3.10696   29.26734  1.000 43.06470  ? 277 ASN A CG   1 
ATOM   4205 O OD1  . ASN A 1 277 ? -7.14204  4.19064   28.68443  1.000 38.80036  ? 277 ASN A OD1  1 
ATOM   4206 N ND2  . ASN A 1 277 ? -8.32260  2.72368   29.91419  1.000 44.80530  ? 277 ASN A ND2  1 
ATOM   4207 H H    . ASN A 1 277 ? -7.50495  0.75377   27.08290  1.000 48.07238  ? 277 ASN A H    1 
ATOM   4208 H HA   . ASN A 1 277 ? -5.87501  2.09331   27.24262  1.000 49.66002  ? 277 ASN A HA   1 
ATOM   4209 H HB2  . ASN A 1 277 ? -6.22943  1.48022   29.97602  1.000 50.33244  ? 277 ASN A HB2  1 
ATOM   4210 H HB3  . ASN A 1 277 ? -5.25804  2.64309   29.49689  1.000 50.33244  ? 277 ASN A HB3  1 
ATOM   4211 H HD21 . ASN A 1 277 ? -9.01239  3.23694   29.93304  1.000 53.75341  ? 277 ASN A HD21 1 
ATOM   4212 H HD22 . ASN A 1 277 ? -8.34200  1.96244   30.31387  1.000 53.75341  ? 277 ASN A HD22 1 
ATOM   4213 N N    . GLY A 1 278 ? -4.35777  -0.21280  26.97669  1.000 41.27677  ? 278 GLY A N    1 
ATOM   4214 C CA   . GLY A 1 278 ? -3.09844  -0.89446  26.77481  1.000 40.56578  ? 278 GLY A CA   1 
ATOM   4215 C C    . GLY A 1 278 ? -2.74850  -1.93199  27.81735  1.000 39.94926  ? 278 GLY A C    1 
ATOM   4216 O O    . GLY A 1 278 ? -1.66024  -2.51829  27.73779  1.000 37.08017  ? 278 GLY A O    1 
ATOM   4217 H H    . GLY A 1 278 ? -4.98322  -0.47300  26.44687  1.000 49.51917  ? 278 GLY A H    1 
ATOM   4218 H HA2  . GLY A 1 278 ? -3.12366  -1.34038  25.91376  1.000 48.66598  ? 278 GLY A HA2  1 
ATOM   4219 H HA3  . GLY A 1 278 ? -2.38795  -0.23410  26.76778  1.000 48.66598  ? 278 GLY A HA3  1 
ATOM   4220 N N    . ARG A 1 279 ? -3.61937  -2.17083  28.79558  1.000 36.94232  ? 279 ARG A N    1 
ATOM   4221 C CA   . ARG A 1 279 ? -3.41608  -3.22964  29.76924  1.000 33.31160  ? 279 ARG A CA   1 
ATOM   4222 C C    . ARG A 1 279 ? -3.95424  -4.53947  29.19939  1.000 33.62495  ? 279 ARG A C    1 
ATOM   4223 O O    . ARG A 1 279 ? -4.54910  -4.57385  28.12038  1.000 34.58150  ? 279 ARG A O    1 
ATOM   4224 C CB   . ARG A 1 279 ? -4.09279  -2.87884  31.09294  1.000 32.43752  ? 279 ARG A CB   1 
ATOM   4225 H H    . ARG A 1 279 ? -4.34487  -1.72470  28.91482  1.000 44.31784  ? 279 ARG A H    1 
ATOM   4226 H HA   . ARG A 1 279 ? -2.46705  -3.32814  29.94398  1.000 39.96097  ? 279 ARG A HA   1 
ATOM   4227 N N    . THR A 1 280 ? -3.75889  -5.63215  29.93532  1.000 33.37096  ? 280 THR A N    1 
ATOM   4228 C CA   . THR A 1 280 ? -4.22467  -6.94371  29.51126  1.000 33.58299  ? 280 THR A CA   1 
ATOM   4229 C C    . THR A 1 280 ? -4.95561  -7.63478  30.65489  1.000 33.91221  ? 280 THR A C    1 
ATOM   4230 O O    . THR A 1 280 ? -4.77269  -7.31218  31.83149  1.000 32.77093  ? 280 THR A O    1 
ATOM   4231 C CB   . THR A 1 280 ? -3.06702  -7.83396  29.03917  1.000 35.97041  ? 280 THR A CB   1 
ATOM   4232 O OG1  . THR A 1 280 ? -2.16488  -8.05360  30.13043  1.000 38.05847  ? 280 THR A OG1  1 
ATOM   4233 C CG2  . THR A 1 280 ? -2.32184  -7.19069  27.88100  1.000 35.00630  ? 280 THR A CG2  1 
ATOM   4234 H H    . THR A 1 280 ? -3.35336  -5.63569  30.69370  1.000 40.03220  ? 280 THR A H    1 
ATOM   4235 H HA   . THR A 1 280 ? -4.84743  -6.82725  28.77676  1.000 40.28664  ? 280 THR A HA   1 
ATOM   4236 H HB   . THR A 1 280 ? -3.41747  -8.68372  28.72934  1.000 43.15154  ? 280 THR A HB   1 
ATOM   4237 H HG1  . THR A 1 280 ? -2.22584  -7.42521  30.68451  1.000 45.65721  ? 280 THR A HG1  1 
ATOM   4238 H HG21 . THR A 1 280 ? -1.89937  -6.36823  28.17422  1.000 41.99461  ? 280 THR A HG21 1 
ATOM   4239 H HG22 . THR A 1 280 ? -1.63894  -7.79458  27.54956  1.000 41.99461  ? 280 THR A HG22 1 
ATOM   4240 H HG23 . THR A 1 280 ? -2.93930  -6.98805  27.16087  1.000 41.99461  ? 280 THR A HG23 1 
ATOM   4241 N N    . ILE A 1 281 ? -5.79756  -8.59542  30.28721  1.000 35.47830  ? 281 ILE A N    1 
ATOM   4242 C CA   . ILE A 1 281 ? -6.50420  -9.44677  31.23704  1.000 36.81370  ? 281 ILE A CA   1 
ATOM   4243 C C    . ILE A 1 281 ? -6.21539  -10.88782 30.84379  1.000 36.42585  ? 281 ILE A C    1 
ATOM   4244 O O    . ILE A 1 281 ? -6.47545  -11.28599 29.70078  1.000 34.61027  ? 281 ILE A O    1 
ATOM   4245 C CB   . ILE A 1 281 ? -8.01664  -9.16396  31.24986  1.000 35.49253  ? 281 ILE A CB   1 
ATOM   4246 C CG1  . ILE A 1 281 ? -8.27826  -7.72334  31.70241  1.000 34.63977  ? 281 ILE A CG1  1 
ATOM   4247 C CG2  . ILE A 1 281 ? -8.76048  -10.14261 32.16846  1.000 34.28087  ? 281 ILE A CG2  1 
ATOM   4248 C CD1  . ILE A 1 281 ? -9.65271  -7.21074  31.35259  1.000 33.22278  ? 281 ILE A CD1  1 
ATOM   4249 H H    . ILE A 1 281 ? -5.98105  -8.77827  29.46715  1.000 42.56101  ? 281 ILE A H    1 
ATOM   4250 H HA   . ILE A 1 281 ? -6.16921  -9.29827  32.13516  1.000 44.16349  ? 281 ILE A HA   1 
ATOM   4251 H HB   . ILE A 1 281 ? -8.34756  -9.28447  30.34605  1.000 42.57809  ? 281 ILE A HB   1 
ATOM   4252 H HG12 . ILE A 1 281 ? -8.18311  -7.67817  32.66668  1.000 41.55476  ? 281 ILE A HG12 1 
ATOM   4253 H HG13 . ILE A 1 281 ? -7.62920  -7.14114  31.27736  1.000 41.55476  ? 281 ILE A HG13 1 
ATOM   4254 H HG21 . ILE A 1 281 ? -9.66793  -10.25269 31.84392  1.000 41.12409  ? 281 ILE A HG21 1 
ATOM   4255 H HG22 . ILE A 1 281 ? -8.30007  -10.99632 32.15932  1.000 41.12409  ? 281 ILE A HG22 1 
ATOM   4256 H HG23 . ILE A 1 281 ? -8.77269  -9.78299  33.06925  1.000 41.12409  ? 281 ILE A HG23 1 
ATOM   4257 H HD11 . ILE A 1 281 ? -9.81357  -6.38428  31.83424  1.000 39.85438  ? 281 ILE A HD11 1 
ATOM   4258 H HD12 . ILE A 1 281 ? -9.69619  -7.05047  30.39691  1.000 39.85438  ? 281 ILE A HD12 1 
ATOM   4259 H HD13 . ILE A 1 281 ? -10.31182 -7.87543  31.60684  1.000 39.85438  ? 281 ILE A HD13 1 
ATOM   4260 N N    . LEU A 1 282 ? -5.67413  -11.66256 31.78370  1.000 34.83741  ? 282 LEU A N    1 
ATOM   4261 C CA   . LEU A 1 282 ? -5.23346  -13.02270 31.50001  1.000 33.88993  ? 282 LEU A CA   1 
ATOM   4262 C C    . LEU A 1 282 ? -4.41588  -13.06679 30.21392  1.000 33.94089  ? 282 LEU A C    1 
ATOM   4263 O O    . LEU A 1 282 ? -4.58428  -13.95782 29.38245  1.000 35.27966  ? 282 LEU A O    1 
ATOM   4264 C CB   . LEU A 1 282 ? -6.42846  -13.97114 31.41299  1.000 32.55247  ? 282 LEU A CB   1 
ATOM   4265 C CG   . LEU A 1 282 ? -7.20145  -14.13825 32.72326  1.000 31.70683  ? 282 LEU A CG   1 
ATOM   4266 C CD1  . LEU A 1 282 ? -8.44556  -14.98309 32.52322  1.000 33.10972  ? 282 LEU A CD1  1 
ATOM   4267 C CD2  . LEU A 1 282 ? -6.30695  -14.74173 33.80087  1.000 32.19478  ? 282 LEU A CD2  1 
ATOM   4268 H H    . LEU A 1 282 ? -5.55152  -11.41897 32.59932  1.000 41.79194  ? 282 LEU A H    1 
ATOM   4269 H HA   . LEU A 1 282 ? -4.66301  -13.32201 32.22520  1.000 40.65497  ? 282 LEU A HA   1 
ATOM   4270 H HB2  . LEU A 1 282 ? -7.04668  -13.62822 30.74883  1.000 39.05001  ? 282 LEU A HB2  1 
ATOM   4271 H HB3  . LEU A 1 282 ? -6.10817  -14.84726 31.14703  1.000 39.05001  ? 282 LEU A HB3  1 
ATOM   4272 H HG   . LEU A 1 282 ? -7.48919  -13.26240 33.02489  1.000 38.03524  ? 282 LEU A HG   1 
ATOM   4273 H HD11 . LEU A 1 282 ? -8.89714  -15.08697 33.37538  1.000 39.71870  ? 282 LEU A HD11 1 
ATOM   4274 H HD12 . LEU A 1 282 ? -9.03107  -14.53818 31.89066  1.000 39.71870  ? 282 LEU A HD12 1 
ATOM   4275 H HD13 . LEU A 1 282 ? -8.18540  -15.85172 32.17869  1.000 39.71870  ? 282 LEU A HD13 1 
ATOM   4276 H HD21 . LEU A 1 282 ? -6.86452  -15.12693 34.49488  1.000 38.62078  ? 282 LEU A HD21 1 
ATOM   4277 H HD22 . LEU A 1 282 ? -5.75244  -15.43035 33.40184  1.000 38.62078  ? 282 LEU A HD22 1 
ATOM   4278 H HD23 . LEU A 1 282 ? -5.74819  -14.04285 34.17535  1.000 38.62078  ? 282 LEU A HD23 1 
ATOM   4279 N N    . GLY A 1 283 ? -3.53381  -12.08206 30.04277  1.000 32.92834  ? 283 GLY A N    1 
ATOM   4280 C CA   . GLY A 1 283 ? -2.62776  -12.05467 28.91296  1.000 34.65318  ? 283 GLY A CA   1 
ATOM   4281 C C    . GLY A 1 283 ? -3.23614  -11.64415 27.59302  1.000 36.51254  ? 283 GLY A C    1 
ATOM   4282 O O    . GLY A 1 283 ? -2.56960  -11.77206 26.56003  1.000 36.27029  ? 283 GLY A O    1 
ATOM   4283 H H    . GLY A 1 283 ? -3.44468  -11.41386 30.57678  1.000 39.50106  ? 283 GLY A H    1 
ATOM   4284 H HA2  . GLY A 1 283 ? -1.91038  -11.43217 29.10988  1.000 41.57087  ? 283 GLY A HA2  1 
ATOM   4285 H HA3  . GLY A 1 283 ? -2.25325  -12.94208 28.79831  1.000 41.57087  ? 283 GLY A HA3  1 
ATOM   4286 N N    . SER A 1 284 ? -4.47005  -11.14782 27.58467  1.000 35.70101  ? 284 SER A N    1 
ATOM   4287 C CA   . SER A 1 284 ? -5.14868  -10.75786 26.35776  1.000 35.13696  ? 284 SER A CA   1 
ATOM   4288 C C    . SER A 1 284 ? -5.43543  -9.26261  26.36945  1.000 35.48913  ? 284 SER A C    1 
ATOM   4289 O O    . SER A 1 284 ? -5.79127  -8.69736  27.40759  1.000 31.87582  ? 284 SER A O    1 
ATOM   4290 C CB   . SER A 1 284 ? -6.46045  -11.53599 26.18131  1.000 34.71071  ? 284 SER A CB   1 
ATOM   4291 O OG   . SER A 1 284 ? -7.05964  -11.23818 24.93127  1.000 38.06430  ? 284 SER A OG   1 
ATOM   4292 H H    . SER A 1 284 ? -4.94205  -11.02609 28.29319  1.000 42.82826  ? 284 SER A H    1 
ATOM   4293 H HA   . SER A 1 284 ? -4.57270  -10.94727 25.60061  1.000 42.15140  ? 284 SER A HA   1 
ATOM   4294 H HB2  . SER A 1 284 ? -6.27167  -12.48656 26.22247  1.000 41.63989  ? 284 SER A HB2  1 
ATOM   4295 H HB3  . SER A 1 284 ? -7.07254  -11.28824 26.89185  1.000 41.63989  ? 284 SER A HB3  1 
ATOM   4296 H HG   . SER A 1 284 ? -6.48224  -11.26665 24.32185  1.000 45.66420  ? 284 SER A HG   1 
ATOM   4297 N N    . ALA A 1 285 ? -5.26570  -8.62675  25.21079  1.000 34.28134  ? 285 ALA A N    1 
ATOM   4298 C CA   . ALA A 1 285 ? -5.68415  -7.24713  24.99947  1.000 36.52049  ? 285 ALA A CA   1 
ATOM   4299 C C    . ALA A 1 285 ? -7.09654  -7.14963  24.43725  1.000 35.95383  ? 285 ALA A C    1 
ATOM   4300 O O    . ALA A 1 285 ? -7.54736  -6.04631  24.11312  1.000 37.63297  ? 285 ALA A O    1 
ATOM   4301 C CB   . ALA A 1 285 ? -4.70420  -6.53424  24.06301  1.000 36.70241  ? 285 ALA A CB   1 
ATOM   4302 H H    . ALA A 1 285 ? -4.90207  -8.98360  24.51795  1.000 41.12465  ? 285 ALA A H    1 
ATOM   4303 H HA   . ALA A 1 285 ? -5.66611  -6.78007  25.84943  1.000 43.81163  ? 285 ALA A HA   1 
ATOM   4304 H HB1  . ALA A 1 285 ? -5.11044  -5.71185  23.74750  1.000 44.02994  ? 285 ALA A HB1  1 
ATOM   4305 H HB2  . ALA A 1 285 ? -3.88967  -6.33498  24.55059  1.000 44.02994  ? 285 ALA A HB2  1 
ATOM   4306 H HB3  . ALA A 1 285 ? -4.50629  -7.11489  23.31163  1.000 44.02994  ? 285 ALA A HB3  1 
ATOM   4307 N N    . LEU A 1 286 ? -7.79438  -8.27475  24.30778  1.000 35.42286  ? 286 LEU A N    1 
ATOM   4308 C CA   . LEU A 1 286 ? -9.17285  -8.32049  23.85378  1.000 36.70580  ? 286 LEU A CA   1 
ATOM   4309 C C    . LEU A 1 286 ? -10.03730 -8.96701  24.92435  1.000 35.62697  ? 286 LEU A C    1 
ATOM   4310 O O    . LEU A 1 286 ? -9.55546  -9.74194  25.75289  1.000 35.65565  ? 286 LEU A O    1 
ATOM   4311 C CB   . LEU A 1 286 ? -9.31975  -9.12733  22.55401  1.000 39.35056  ? 286 LEU A CB   1 
ATOM   4312 C CG   . LEU A 1 286 ? -8.61643  -8.63271  21.29304  1.000 40.05066  ? 286 LEU A CG   1 
ATOM   4313 C CD1  . LEU A 1 286 ? -9.11083  -9.42765  20.09494  1.000 38.55989  ? 286 LEU A CD1  1 
ATOM   4314 C CD2  . LEU A 1 286 ? -8.84581  -7.14635  21.09085  1.000 44.09080  ? 286 LEU A CD2  1 
ATOM   4315 H H    . LEU A 1 286 ? -7.47450  -9.05313  24.48498  1.000 42.49447  ? 286 LEU A H    1 
ATOM   4316 H HA   . LEU A 1 286 ? -9.47860  -7.41441  23.69115  1.000 44.03400  ? 286 LEU A HA   1 
ATOM   4317 H HB2  . LEU A 1 286 ? -8.97963  -10.01937 22.72571  1.000 47.20772  ? 286 LEU A HB2  1 
ATOM   4318 H HB3  . LEU A 1 286 ? -10.26553 -9.16789  22.34248  1.000 47.20772  ? 286 LEU A HB3  1 
ATOM   4319 H HG   . LEU A 1 286 ? -7.65940  -8.76408  21.38103  1.000 48.04784  ? 286 LEU A HG   1 
ATOM   4320 H HD11 . LEU A 1 286 ? -10.06177 -9.27217  19.98342  1.000 46.25891  ? 286 LEU A HD11 1 
ATOM   4321 H HD12 . LEU A 1 286 ? -8.63280  -9.13553  19.30308  1.000 46.25891  ? 286 LEU A HD12 1 
ATOM   4322 H HD13 . LEU A 1 286 ? -8.94600  -10.37059 20.25179  1.000 46.25891  ? 286 LEU A HD13 1 
ATOM   4323 H HD21 . LEU A 1 286 ? -9.77854  -6.94428  21.26433  1.000 52.89601  ? 286 LEU A HD21 1 
ATOM   4324 H HD22 . LEU A 1 286 ? -8.28059  -6.65307  21.70574  1.000 52.89601  ? 286 LEU A HD22 1 
ATOM   4325 H HD23 . LEU A 1 286 ? -8.62152  -6.91373  20.17626  1.000 52.89601  ? 286 LEU A HD23 1 
ATOM   4326 N N    . LEU A 1 287 ? -11.32664 -8.64683  24.89550  1.000 35.49958  ? 287 LEU A N    1 
ATOM   4327 C CA   . LEU A 1 287 ? -12.29892 -9.35815  25.71528  1.000 35.33423  ? 287 LEU A CA   1 
ATOM   4328 C C    . LEU A 1 287 ? -12.57630 -10.70056 25.04970  1.000 35.03272  ? 287 LEU A C    1 
ATOM   4329 O O    . LEU A 1 287 ? -13.13365 -10.75301 23.94919  1.000 36.61503  ? 287 LEU A O    1 
ATOM   4330 C CB   . LEU A 1 287 ? -13.56128 -8.52035  25.88108  1.000 35.68222  ? 287 LEU A CB   1 
ATOM   4331 C CG   . LEU A 1 287 ? -13.30466 -7.20796  26.63456  1.000 33.56399  ? 287 LEU A CG   1 
ATOM   4332 C CD1  . LEU A 1 287 ? -14.54991 -6.35194  26.71128  1.000 32.87262  ? 287 LEU A CD1  1 
ATOM   4333 C CD2  . LEU A 1 287 ? -12.76693 -7.48721  28.03076  1.000 33.99485  ? 287 LEU A CD2  1 
ATOM   4334 H H    . LEU A 1 287 ? -11.66230 -8.02175  24.40950  1.000 42.58655  ? 287 LEU A H    1 
ATOM   4335 H HA   . LEU A 1 287 ? -11.94508 -9.52401  26.60308  1.000 42.38812  ? 287 LEU A HA   1 
ATOM   4336 H HB2  . LEU A 1 287 ? -13.91167 -8.30071  25.00365  1.000 42.80571  ? 287 LEU A HB2  1 
ATOM   4337 H HB3  . LEU A 1 287 ? -14.21614 -9.03209  26.38125  1.000 42.80571  ? 287 LEU A HB3  1 
ATOM   4338 H HG   . LEU A 1 287 ? -12.63768 -6.70511  26.14142  1.000 40.26383  ? 287 LEU A HG   1 
ATOM   4339 H HD11 . LEU A 1 287 ? -15.14446 -6.71895  27.38413  1.000 39.43419  ? 287 LEU A HD11 1 
ATOM   4340 H HD12 . LEU A 1 287 ? -14.29672 -5.44698  26.95176  1.000 39.43419  ? 287 LEU A HD12 1 
ATOM   4341 H HD13 . LEU A 1 287 ? -14.98829 -6.35390  25.84599  1.000 39.43419  ? 287 LEU A HD13 1 
ATOM   4342 H HD21 . LEU A 1 287 ? -12.79998 -6.66939  28.55131  1.000 40.78087  ? 287 LEU A HD21 1 
ATOM   4343 H HD22 . LEU A 1 287 ? -13.31547 -8.16856  28.45000  1.000 40.78087  ? 287 LEU A HD22 1 
ATOM   4344 H HD23 . LEU A 1 287 ? -11.85063 -7.79751  27.96005  1.000 40.78087  ? 287 LEU A HD23 1 
ATOM   4345 N N    A GLU A 1 288 ? -12.18627 -11.78247 25.71794  0.500 34.99955  ? 288 GLU A N    1 
ATOM   4346 N N    B GLU A 1 288 ? -12.18235 -11.78635 25.71066  0.500 35.23953  ? 288 GLU A N    1 
ATOM   4347 C CA   A GLU A 1 288 ? -12.28907 -13.12623 25.16407  0.500 35.20053  ? 288 GLU A CA   1 
ATOM   4348 C CA   B GLU A 1 288 ? -12.28190 -13.12434 25.14041  0.500 35.20051  ? 288 GLU A CA   1 
ATOM   4349 C C    A GLU A 1 288 ? -13.66181 -13.71313 25.47035  0.500 34.05656  ? 288 GLU A C    1 
ATOM   4350 C C    B GLU A 1 288 ? -13.64635 -13.72220 25.46325  0.500 33.93574  ? 288 GLU A C    1 
ATOM   4351 O O    A GLU A 1 288 ? -14.12062 -13.66670 26.61549  0.500 31.55342  ? 288 GLU A O    1 
ATOM   4352 O O    B GLU A 1 288 ? -14.08797 -13.68205 26.61499  0.500 32.18705  ? 288 GLU A O    1 
ATOM   4353 C CB   A GLU A 1 288 ? -11.17991 -14.00814 25.73900  0.500 37.11202  ? 288 GLU A CB   1 
ATOM   4354 C CB   B GLU A 1 288 ? -11.15869 -14.01125 25.67927  0.500 37.74611  ? 288 GLU A CB   1 
ATOM   4355 C CG   A GLU A 1 288 ? -11.20888 -15.45527 25.28014  0.500 37.32617  ? 288 GLU A CG   1 
ATOM   4356 C CG   B GLU A 1 288 ? -9.76149  -13.51382 25.32885  0.500 37.00051  ? 288 GLU A CG   1 
ATOM   4357 C CD   A GLU A 1 288 ? -10.99777 -15.60076 23.78648  0.500 37.70289  ? 288 GLU A CD   1 
ATOM   4358 C CD   B GLU A 1 288 ? -9.50752  -13.49450 23.83340  0.500 38.98189  ? 288 GLU A CD   1 
ATOM   4359 O OE1  A GLU A 1 288 ? -9.96302  -15.11026 23.28259  0.500 39.67751  ? 288 GLU A OE1  1 
ATOM   4360 O OE1  B GLU A 1 288 ? -10.03640 -14.38243 23.12973  0.500 39.63475  ? 288 GLU A OE1  1 
ATOM   4361 O OE2  A GLU A 1 288 ? -11.87419 -16.19404 23.11966  0.500 32.99858  ? 288 GLU A OE2  1 
ATOM   4362 O OE2  B GLU A 1 288 ? -8.78535  -12.58805 23.36259  0.500 38.64161  ? 288 GLU A OE2  1 
ATOM   4363 H H    A GLU A 1 288 ? -11.85208 -11.76244 26.51010  0.500 41.98651  ? 288 GLU A H    1 
ATOM   4364 H H    B GLU A 1 288 ? -11.84895 -11.77249 26.50328  0.500 42.27448  ? 288 GLU A H    1 
ATOM   4365 H HA   A GLU A 1 288 ? -12.19190 -13.09699 24.19939  0.500 42.22768  ? 288 GLU A HA   1 
ATOM   4366 H HA   B GLU A 1 288 ? -12.19703 -13.08008 24.17514  0.500 42.22766  ? 288 GLU A HA   1 
ATOM   4367 H HB2  A GLU A 1 288 ? -10.32388 -13.63623 25.47481  0.500 44.52147  ? 288 GLU A HB2  1 
ATOM   4368 H HB2  B GLU A 1 288 ? -11.22639 -14.04698 26.64625  0.500 45.28238  ? 288 GLU A HB2  1 
ATOM   4369 H HB3  A GLU A 1 288 ? -11.25753 -14.00790 26.70589  0.500 44.52147  ? 288 GLU A HB3  1 
ATOM   4370 H HB3  B GLU A 1 288 ? -11.25824 -14.90125 25.30661  0.500 45.28238  ? 288 GLU A HB3  1 
ATOM   4371 H HG2  A GLU A 1 288 ? -10.50342 -15.94433 25.73184  0.500 44.77844  ? 288 GLU A HG2  1 
ATOM   4372 H HG2  B GLU A 1 288 ? -9.65392  -12.60984 25.66372  0.500 44.38765  ? 288 GLU A HG2  1 
ATOM   4373 H HG3  A GLU A 1 288 ? -12.07205 -15.83938 25.49991  0.500 44.77844  ? 288 GLU A HG3  1 
ATOM   4374 H HG3  B GLU A 1 288 ? -9.10507  -14.09937 25.73768  0.500 44.38765  ? 288 GLU A HG3  1 
ATOM   4375 N N    . ASP A 1 289 ? -14.31425 -14.27354 24.44241  1.000 32.51118  ? 289 ASP A N    1 
ATOM   4376 C CA   . ASP A 1 289 ? -15.69006 -14.74453 24.57364  1.000 28.58482  ? 289 ASP A CA   1 
ATOM   4377 C C    . ASP A 1 289 ? -15.87787 -16.20583 24.17218  1.000 28.27587  ? 289 ASP A C    1 
ATOM   4378 O O    . ASP A 1 289 ? -17.01526 -16.63008 23.94116  1.000 27.03889  ? 289 ASP A O    1 
ATOM   4379 C CB   . ASP A 1 289 ? -16.63237 -13.85799 23.75075  1.000 27.43606  ? 289 ASP A CB   1 
ATOM   4380 C CG   . ASP A 1 289 ? -16.59034 -14.17310 22.26477  1.000 30.82776  ? 289 ASP A CG   1 
ATOM   4381 O OD1  . ASP A 1 289 ? -15.51933 -14.57761 21.76278  1.000 27.75882  ? 289 ASP A OD1  1 
ATOM   4382 O OD2  . ASP A 1 289 ? -17.63898 -14.01030 21.59956  1.000 28.74737  ? 289 ASP A OD2  1 
ATOM   4383 H H    . ASP A 1 289 ? -13.98431 -14.38517 23.65611  1.000 39.00046  ? 289 ASP A H    1 
ATOM   4384 H HA   . ASP A 1 289 ? -15.92857 -14.68198 25.51177  1.000 34.28883  ? 289 ASP A HA   1 
ATOM   4385 H HB2  . ASP A 1 289 ? -17.54204 -13.99174 24.05981  1.000 32.91032  ? 289 ASP A HB2  1 
ATOM   4386 H HB3  . ASP A 1 289 ? -16.37533 -12.93000 23.86766  1.000 32.91032  ? 289 ASP A HB3  1 
ATOM   4387 N N    . GLU A 1 290 ? -14.80697 -16.99730 24.10104  1.000 28.01330  ? 290 GLU A N    1 
ATOM   4388 C CA   . GLU A 1 290 ? -14.91735 -18.40952 23.75000  1.000 29.15243  ? 290 GLU A CA   1 
ATOM   4389 C C    . GLU A 1 290 ? -14.61239 -19.31204 24.94173  1.000 30.28585  ? 290 GLU A C    1 
ATOM   4390 O O    . GLU A 1 290 ? -14.09073 -20.41662 24.77858  1.000 27.90767  ? 290 GLU A O    1 
ATOM   4391 C CB   . GLU A 1 290 ? -14.01898 -18.74322 22.55638  1.000 29.40358  ? 290 GLU A CB   1 
ATOM   4392 C CG   . GLU A 1 290 ? -14.45566 -18.01303 21.28547  1.000 30.79770  ? 290 GLU A CG   1 
ATOM   4393 C CD   . GLU A 1 290 ? -14.13720 -18.76197 20.00124  1.000 34.50526  ? 290 GLU A CD   1 
ATOM   4394 O OE1  . GLU A 1 290 ? -13.29207 -19.68007 20.02560  1.000 32.02577  ? 290 GLU A OE1  1 
ATOM   4395 O OE2  . GLU A 1 290 ? -14.74380 -18.42455 18.96257  1.000 34.19112  ? 290 GLU A OE2  1 
ATOM   4396 H H    . GLU A 1 290 ? -14.00207 -16.73537 24.25313  1.000 33.60301  ? 290 GLU A H    1 
ATOM   4397 H HA   . GLU A 1 290 ? -15.83051 -18.59176 23.47829  1.000 34.96996  ? 290 GLU A HA   1 
ATOM   4398 H HB2  . GLU A 1 290 ? -13.10815 -18.47900 22.76002  1.000 35.27134  ? 290 GLU A HB2  1 
ATOM   4399 H HB3  . GLU A 1 290 ? -14.05744 -19.69740 22.38618  1.000 35.27134  ? 290 GLU A HB3  1 
ATOM   4400 H HG2  . GLU A 1 290 ? -15.41579 -17.87886 21.31789  1.000 36.94428  ? 290 GLU A HG2  1 
ATOM   4401 H HG3  . GLU A 1 290 ? -14.00208 -17.15647 21.24718  1.000 36.94428  ? 290 GLU A HG3  1 
ATOM   4402 N N    . PHE A 1 291 ? -14.94047 -18.83985 26.14562  1.000 26.28221  ? 291 PHE A N    1 
ATOM   4403 C CA   . PHE A 1 291 ? -14.96585 -19.64511 27.35802  1.000 28.09091  ? 291 PHE A CA   1 
ATOM   4404 C C    . PHE A 1 291 ? -16.37562 -19.57302 27.92862  1.000 27.51440  ? 291 PHE A C    1 
ATOM   4405 O O    . PHE A 1 291 ? -16.85920 -18.48202 28.24079  1.000 25.90649  ? 291 PHE A O    1 
ATOM   4406 C CB   . PHE A 1 291 ? -13.96239 -19.13862 28.39709  1.000 29.30797  ? 291 PHE A CB   1 
ATOM   4407 C CG   . PHE A 1 291 ? -12.52196 -19.30059 27.99990  1.000 28.79386  ? 291 PHE A CG   1 
ATOM   4408 C CD1  . PHE A 1 291 ? -11.89647 -20.53174 28.09502  1.000 33.38179  ? 291 PHE A CD1  1 
ATOM   4409 C CD2  . PHE A 1 291 ? -11.78345 -18.21149 27.56745  1.000 31.40042  ? 291 PHE A CD2  1 
ATOM   4410 C CE1  . PHE A 1 291 ? -10.56826 -20.67957 27.74082  1.000 32.30231  ? 291 PHE A CE1  1 
ATOM   4411 C CE2  . PHE A 1 291 ? -10.45438 -18.35243 27.21608  1.000 34.10205  ? 291 PHE A CE2  1 
ATOM   4412 C CZ   . PHE A 1 291 ? -9.84630  -19.58921 27.30303  1.000 32.99180  ? 291 PHE A CZ   1 
ATOM   4413 H H    . PHE A 1 291 ? -15.16082 -18.02059 26.28659  1.000 31.52570  ? 291 PHE A H    1 
ATOM   4414 H HA   . PHE A 1 291 ? -14.73965 -20.56323 27.14171  1.000 33.69613  ? 291 PHE A HA   1 
ATOM   4415 H HB2  . PHE A 1 291 ? -14.12119 -18.19326 28.54537  1.000 35.15661  ? 291 PHE A HB2  1 
ATOM   4416 H HB3  . PHE A 1 291 ? -14.09626 -19.63092 29.22208  1.000 35.15661  ? 291 PHE A HB3  1 
ATOM   4417 H HD1  . PHE A 1 291 ? -12.37526 -21.26807 28.40077  1.000 40.04519  ? 291 PHE A HD1  1 
ATOM   4418 H HD2  . PHE A 1 291 ? -12.18688 -17.37533 27.51289  1.000 37.66754  ? 291 PHE A HD2  1 
ATOM   4419 H HE1  . PHE A 1 291 ? -10.16180 -21.51410 27.79777  1.000 38.74982  ? 291 PHE A HE1  1 
ATOM   4420 H HE2  . PHE A 1 291 ? -9.97004  -17.61522 26.92141  1.000 40.90951  ? 291 PHE A HE2  1 
ATOM   4421 H HZ   . PHE A 1 291 ? -8.95206  -19.68659 27.06692  1.000 39.57720  ? 291 PHE A HZ   1 
ATOM   4422 N N    . THR A 1 292 ? -17.03072 -20.72048 28.06263  1.000 27.99363  ? 292 THR A N    1 
ATOM   4423 C CA   . THR A 1 292 ? -18.32891 -20.76370 28.71380  1.000 28.57916  ? 292 THR A CA   1 
ATOM   4424 C C    . THR A 1 292 ? -18.16461 -20.71468 30.22995  1.000 28.99560  ? 292 THR A C    1 
ATOM   4425 O O    . THR A 1 292 ? -17.07131 -20.93586 30.75764  1.000 27.61643  ? 292 THR A O    1 
ATOM   4426 C CB   . THR A 1 292 ? -19.08520 -22.03393 28.33128  1.000 30.74923  ? 292 THR A CB   1 
ATOM   4427 O OG1  . THR A 1 292 ? -18.42524 -23.17112 28.89910  1.000 30.01344  ? 292 THR A OG1  1 
ATOM   4428 C CG2  . THR A 1 292 ? -19.16379 -22.19314 26.82027  1.000 31.18407  ? 292 THR A CG2  1 
ATOM   4429 H H    . THR A 1 292 ? -16.74455 -21.48271 27.78567  1.000 33.57941  ? 292 THR A H    1 
ATOM   4430 H HA   . THR A 1 292 ? -18.85273 -20.00048 28.42395  1.000 34.28204  ? 292 THR A HA   1 
ATOM   4431 H HB   . THR A 1 292 ? -19.99226 -21.97976 28.67070  1.000 36.88612  ? 292 THR A HB   1 
ATOM   4432 H HG1  . THR A 1 292 ? -18.97745 -23.79205 29.02198  1.000 36.00318  ? 292 THR A HG1  1 
ATOM   4433 H HG21 . THR A 1 292 ? -18.27662 -22.33647 26.45519  1.000 37.40793  ? 292 THR A HG21 1 
ATOM   4434 H HG22 . THR A 1 292 ? -19.72328 -22.95295 26.59539  1.000 37.40793  ? 292 THR A HG22 1 
ATOM   4435 H HG23 . THR A 1 292 ? -19.54289 -21.39416 26.42176  1.000 37.40793  ? 292 THR A HG23 1 
ATOM   4436 N N    . PRO A 1 293 ? -19.24001 -20.42654 30.95812  1.000 28.48382  ? 293 PRO A N    1 
ATOM   4437 C CA   . PRO A 1 293 ? -19.17715 -20.58256 32.42081  1.000 28.77498  ? 293 PRO A CA   1 
ATOM   4438 C C    . PRO A 1 293 ? -18.74198 -21.97237 32.85065  1.000 32.27147  ? 293 PRO A C    1 
ATOM   4439 O O    . PRO A 1 293 ? -17.92221 -22.10664 33.76595  1.000 31.92017  ? 293 PRO A O    1 
ATOM   4440 C CB   . PRO A 1 293 ? -20.61033 -20.25936 32.85505  1.000 29.85621  ? 293 PRO A CB   1 
ATOM   4441 C CG   . PRO A 1 293 ? -21.08099 -19.28807 31.82132  1.000 28.65717  ? 293 PRO A CG   1 
ATOM   4442 C CD   . PRO A 1 293 ? -20.49068 -19.77809 30.52671  1.000 28.03117  ? 293 PRO A CD   1 
ATOM   4443 H HA   . PRO A 1 293 ? -18.57469 -19.92754 32.80668  1.000 34.51702  ? 293 PRO A HA   1 
ATOM   4444 H HB2  . PRO A 1 293 ? -21.15115 -21.06460 32.85371  1.000 35.81450  ? 293 PRO A HB2  1 
ATOM   4445 H HB3  . PRO A 1 293 ? -20.61130 -19.86053 33.73926  1.000 35.81450  ? 293 PRO A HB3  1 
ATOM   4446 H HG2  . PRO A 1 293 ? -22.05022 -19.29029 31.78290  1.000 34.37565  ? 293 PRO A HG2  1 
ATOM   4447 H HG3  . PRO A 1 293 ? -20.75942 -18.39790 32.03369  1.000 34.37565  ? 293 PRO A HG3  1 
ATOM   4448 H HD2  . PRO A 1 293 ? -21.08111 -20.41604 30.09622  1.000 33.62446  ? 293 PRO A HD2  1 
ATOM   4449 H HD3  . PRO A 1 293 ? -20.30818 -19.03786 29.92700  1.000 33.62446  ? 293 PRO A HD3  1 
ATOM   4450 N N    . PHE A 1 294 ? -19.27001 -23.01586 32.20586  1.000 34.02055  ? 294 PHE A N    1 
ATOM   4451 C CA   . PHE A 1 294 ? -18.82327 -24.37676 32.49359  1.000 36.53842  ? 294 PHE A CA   1 
ATOM   4452 C C    . PHE A 1 294 ? -17.33504 -24.53462 32.20223  1.000 36.80335  ? 294 PHE A C    1 
ATOM   4453 O O    . PHE A 1 294 ? -16.60774 -25.17494 32.97081  1.000 36.63301  ? 294 PHE A O    1 
ATOM   4454 C CB   . PHE A 1 294 ? -19.65618 -25.36604 31.67018  1.000 37.68541  ? 294 PHE A CB   1 
ATOM   4455 C CG   . PHE A 1 294 ? -19.34812 -26.81391 31.94100  1.000 47.27284  ? 294 PHE A CG   1 
ATOM   4456 C CD1  . PHE A 1 294 ? -18.34492 -27.46919 31.24187  1.000 53.30433  ? 294 PHE A CD1  1 
ATOM   4457 C CD2  . PHE A 1 294 ? -20.08275 -27.53139 32.87033  1.000 55.03449  ? 294 PHE A CD2  1 
ATOM   4458 C CE1  . PHE A 1 294 ? -18.07121 -28.80446 31.48181  1.000 51.97046  ? 294 PHE A CE1  1 
ATOM   4459 C CE2  . PHE A 1 294 ? -19.80806 -28.86872 33.11155  1.000 58.83163  ? 294 PHE A CE2  1 
ATOM   4460 C CZ   . PHE A 1 294 ? -18.80253 -29.50155 32.41628  1.000 52.92002  ? 294 PHE A CZ   1 
ATOM   4461 H H    . PHE A 1 294 ? -19.88181 -22.96254 31.60381  1.000 40.81170  ? 294 PHE A H    1 
ATOM   4462 H HA   . PHE A 1 294 ? -18.96020 -24.57551 33.43308  1.000 43.83315  ? 294 PHE A HA   1 
ATOM   4463 H HB2  . PHE A 1 294 ? -20.59428 -25.22313 31.87130  1.000 45.20954  ? 294 PHE A HB2  1 
ATOM   4464 H HB3  . PHE A 1 294 ? -19.48997 -25.20189 30.72873  1.000 45.20954  ? 294 PHE A HB3  1 
ATOM   4465 H HD1  . PHE A 1 294 ? -17.85069 -27.00591 30.60468  1.000 63.95224  ? 294 PHE A HD1  1 
ATOM   4466 H HD2  . PHE A 1 294 ? -20.76815 -27.11129 33.33792  1.000 66.02843  ? 294 PHE A HD2  1 
ATOM   4467 H HE1  . PHE A 1 294 ? -17.39219 -29.23121 31.01094  1.000 62.35160  ? 294 PHE A HE1  1 
ATOM   4468 H HE2  . PHE A 1 294 ? -20.30326 -29.33842 33.74326  1.000 70.58500  ? 294 PHE A HE2  1 
ATOM   4469 H HZ   . PHE A 1 294 ? -18.61773 -30.39859 32.57776  1.000 63.49107  ? 294 PHE A HZ   1 
ATOM   4470 N N    . ASP A 1 295 ? -16.86273 -23.95076 31.09713  1.000 32.89347  ? 295 ASP A N    1 
ATOM   4471 C CA   . ASP A 1 295 ? -15.44513 -24.03185 30.76054  1.000 34.26975  ? 295 ASP A CA   1 
ATOM   4472 C C    . ASP A 1 295 ? -14.57502 -23.47320 31.87980  1.000 36.02735  ? 295 ASP A C    1 
ATOM   4473 O O    . ASP A 1 295 ? -13.55068 -24.06757 32.23773  1.000 34.81923  ? 295 ASP A O    1 
ATOM   4474 C CB   . ASP A 1 295 ? -15.17343 -23.27635 29.45927  1.000 34.76996  ? 295 ASP A CB   1 
ATOM   4475 C CG   . ASP A 1 295 ? -15.68197 -24.01530 28.23345  1.000 34.36452  ? 295 ASP A CG   1 
ATOM   4476 O OD1  . ASP A 1 295 ? -16.10134 -25.18731 28.36077  1.000 33.47528  ? 295 ASP A OD1  1 
ATOM   4477 O OD2  . ASP A 1 295 ? -15.66314 -23.41710 27.13857  1.000 32.76706  ? 295 ASP A OD2  1 
ATOM   4478 H H    . ASP A 1 295 ? -17.33801 -23.50760 30.53382  1.000 39.45921  ? 295 ASP A H    1 
ATOM   4479 H HA   . ASP A 1 295 ? -15.21154 -24.96430 30.63066  1.000 41.11075  ? 295 ASP A HA   1 
ATOM   4480 H HB2  . ASP A 1 295 ? -15.61725 -22.41460 29.49553  1.000 41.71100  ? 295 ASP A HB2  1 
ATOM   4481 H HB3  . ASP A 1 295 ? -14.21653 -23.15276 29.35942  1.000 41.71100  ? 295 ASP A HB3  1 
ATOM   4482 N N    . VAL A 1 296 ? -14.96343 -22.32707 32.44204  1.000 34.73029  ? 296 VAL A N    1 
ATOM   4483 C CA   . VAL A 1 296 ? -14.13866 -21.68350 33.45955  1.000 35.49268  ? 296 VAL A CA   1 
ATOM   4484 C C    . VAL A 1 296 ? -14.10998 -22.52337 34.73099  1.000 35.04448  ? 296 VAL A C    1 
ATOM   4485 O O    . VAL A 1 296 ? -13.04189 -22.78977 35.29479  1.000 36.31182  ? 296 VAL A O    1 
ATOM   4486 C CB   . VAL A 1 296 ? -14.64493 -20.25619 33.73865  1.000 32.05365  ? 296 VAL A CB   1 
ATOM   4487 C CG1  . VAL A 1 296 ? -13.77076 -19.57785 34.78369  1.000 33.73686  ? 296 VAL A CG1  1 
ATOM   4488 C CG2  . VAL A 1 296 ? -14.66654 -19.43596 32.45333  1.000 31.15598  ? 296 VAL A CG2  1 
ATOM   4489 H H    . VAL A 1 296 ? -15.69061 -21.90843 32.25351  1.000 41.66339  ? 296 VAL A H    1 
ATOM   4490 H HA   . VAL A 1 296 ? -13.23125 -21.61931 33.12283  1.000 42.57826  ? 296 VAL A HA   1 
ATOM   4491 H HB   . VAL A 1 296 ? -15.55038 -20.30739 34.08281  1.000 38.45143  ? 296 VAL A HB   1 
ATOM   4492 H HG11 . VAL A 1 296 ? -13.79963 -20.09528 35.60364  1.000 40.47127  ? 296 VAL A HG11 1 
ATOM   4493 H HG12 . VAL A 1 296 ? -12.86007 -19.53303 34.45273  1.000 40.47127  ? 296 VAL A HG12 1 
ATOM   4494 H HG13 . VAL A 1 296 ? -14.10842 -18.68297 34.94520  1.000 40.47127  ? 296 VAL A HG13 1 
ATOM   4495 H HG21 . VAL A 1 296 ? -15.12800 -19.93989 31.76485  1.000 37.37423  ? 296 VAL A HG21 1 
ATOM   4496 H HG22 . VAL A 1 296 ? -15.13109 -18.60079 32.61944  1.000 37.37423  ? 296 VAL A HG22 1 
ATOM   4497 H HG23 . VAL A 1 296 ? -13.75396 -19.25760 32.17715  1.000 37.37423  ? 296 VAL A HG23 1 
ATOM   4498 N N    . VAL A 1 297 ? -15.28389 -22.93377 35.21325  1.000 33.03957  ? 297 VAL A N    1 
ATOM   4499 C CA   . VAL A 1 297 ? -15.34215 -23.77177 36.40788  1.000 35.85404  ? 297 VAL A CA   1 
ATOM   4500 C C    . VAL A 1 297 ? -14.50624 -25.02962 36.20919  1.000 40.56719  ? 297 VAL A C    1 
ATOM   4501 O O    . VAL A 1 297 ? -13.73562 -25.42975 37.09016  1.000 41.62605  ? 297 VAL A O    1 
ATOM   4502 C CB   . VAL A 1 297 ? -16.80297 -24.11299 36.75267  1.000 38.47822  ? 297 VAL A CB   1 
ATOM   4503 C CG1  . VAL A 1 297 ? -16.86028 -25.19710 37.81893  1.000 39.95907  ? 297 VAL A CG1  1 
ATOM   4504 C CG2  . VAL A 1 297 ? -17.53565 -22.86747 37.21779  1.000 36.13646  ? 297 VAL A CG2  1 
ATOM   4505 H H    . VAL A 1 297 ? -16.04982 -22.74325 34.87172  1.000 39.63453  ? 297 VAL A H    1 
ATOM   4506 H HA   . VAL A 1 297 ? -14.96682 -23.27655 37.15272  1.000 43.01189  ? 297 VAL A HA   1 
ATOM   4507 H HB   . VAL A 1 297 ? -17.24552 -24.44979 35.95793  1.000 46.16091  ? 297 VAL A HB   1 
ATOM   4508 H HG11 . VAL A 1 297 ? -16.08992 -25.10801 38.40160  1.000 47.93793  ? 297 VAL A HG11 1 
ATOM   4509 H HG12 . VAL A 1 297 ? -17.67687 -25.09263 38.33194  1.000 47.93793  ? 297 VAL A HG12 1 
ATOM   4510 H HG13 . VAL A 1 297 ? -16.84975 -26.06562 37.38713  1.000 47.93793  ? 297 VAL A HG13 1 
ATOM   4511 H HG21 . VAL A 1 297 ? -17.37903 -22.15266 36.58107  1.000 43.35080  ? 297 VAL A HG21 1 
ATOM   4512 H HG22 . VAL A 1 297 ? -18.48469 -23.06079 37.27124  1.000 43.35080  ? 297 VAL A HG22 1 
ATOM   4513 H HG23 . VAL A 1 297 ? -17.20049 -22.61163 38.09136  1.000 43.35080  ? 297 VAL A HG23 1 
ATOM   4514 N N    . ARG A 1 298 ? -14.64695 -25.67116 35.04583  1.000 38.80382  ? 298 ARG A N    1 
ATOM   4515 C CA   . ARG A 1 298 ? -13.84441 -26.84872 34.73454  1.000 39.79655  ? 298 ARG A CA   1 
ATOM   4516 C C    . ARG A 1 298 ? -12.36141 -26.58401 34.97479  1.000 41.52723  ? 298 ARG A C    1 
ATOM   4517 O O    . ARG A 1 298 ? -11.70378 -27.28676 35.74932  1.000 42.20592  ? 298 ARG A O    1 
ATOM   4518 C CB   . ARG A 1 298 ? -14.07466 -27.27365 33.27889  1.000 42.91825  ? 298 ARG A CB   1 
ATOM   4519 C CG   . ARG A 1 298 ? -15.01843 -28.45007 33.10687  1.000 49.02711  ? 298 ARG A CG   1 
ATOM   4520 C CD   . ARG A 1 298 ? -14.74260 -29.22836 31.81720  1.000 54.73978  ? 298 ARG A CD   1 
ATOM   4521 N NE   . ARG A 1 298 ? -15.09780 -28.48966 30.60759  1.000 53.69141  ? 298 ARG A NE   1 
ATOM   4522 C CZ   . ARG A 1 298 ? -14.25240 -28.13481 29.64467  1.000 54.73425  ? 298 ARG A CZ   1 
ATOM   4523 N NH1  . ARG A 1 298 ? -12.95731 -28.41058 29.71298  1.000 52.69808  ? 298 ARG A NH1  1 
ATOM   4524 N NH2  . ARG A 1 298 ? -14.72153 -27.49368 28.57830  1.000 53.70864  ? 298 ARG A NH2  1 
ATOM   4525 H H    . ARG A 1 298 ? -15.19754 -25.44391 34.42550  1.000 46.55164  ? 298 ARG A H    1 
ATOM   4526 H HA   . ARG A 1 298 ? -14.12689 -27.57324 35.31434  1.000 47.74290  ? 298 ARG A HA   1 
ATOM   4527 H HB2  . ARG A 1 298 ? -14.45145 -26.52276 32.79403  1.000 51.48894  ? 298 ARG A HB2  1 
ATOM   4528 H HB3  . ARG A 1 298 ? -13.22124 -27.52397 32.89171  1.000 51.48894  ? 298 ARG A HB3  1 
ATOM   4529 H HG2  . ARG A 1 298 ? -14.91024 -29.05759 33.85527  1.000 58.81958  ? 298 ARG A HG2  1 
ATOM   4530 H HG3  . ARG A 1 298 ? -15.93140 -28.12406 33.07349  1.000 58.81958  ? 298 ARG A HG3  1 
ATOM   4531 H HD2  . ARG A 1 298 ? -13.79604 -29.43542 31.77179  1.000 65.67479  ? 298 ARG A HD2  1 
ATOM   4532 H HD3  . ARG A 1 298 ? -15.26134 -30.04793 31.82803  1.000 65.67479  ? 298 ARG A HD3  1 
ATOM   4533 H HE   . ARG A 1 298 ? -15.92242 -28.26574 30.51038  1.000 64.41674  ? 298 ARG A HE   1 
ATOM   4534 H HH11 . ARG A 1 298 ? -12.64243 -28.83048 30.39425  1.000 63.22474  ? 298 ARG A HH11 1 
ATOM   4535 H HH12 . ARG A 1 298 ? -12.43216 -28.16955 29.07601  1.000 63.22474  ? 298 ARG A HH12 1 
ATOM   4536 H HH21 . ARG A 1 298 ? -15.56055 -27.31446 28.51896  1.000 64.43742  ? 298 ARG A HH21 1 
ATOM   4537 H HH22 . ARG A 1 298 ? -14.18591 -27.25827 27.94799  1.000 64.43742  ? 298 ARG A HH22 1 
ATOM   4538 N N    . GLN A 1 299 ? -11.81876 -25.56255 34.30848  1.000 40.24076  ? 299 GLN A N    1 
ATOM   4539 C CA   . GLN A 1 299 ? -10.37738 -25.34591 34.33182  1.000 40.50311  ? 299 GLN A CA   1 
ATOM   4540 C C    . GLN A 1 299 ? -9.88455  -24.80999 35.66787  1.000 40.18580  ? 299 GLN A C    1 
ATOM   4541 O O    . GLN A 1 299 ? -8.71356  -25.00673 36.00350  1.000 40.36518  ? 299 GLN A O    1 
ATOM   4542 C CB   . GLN A 1 299 ? -9.96887  -24.38942 33.21165  1.000 35.73967  ? 299 GLN A CB   1 
ATOM   4543 C CG   . GLN A 1 299 ? -8.46096  -24.26801 33.04625  1.000 33.91283  ? 299 GLN A CG   1 
ATOM   4544 C CD   . GLN A 1 299 ? -8.04133  -23.31449 31.93823  1.000 32.82365  ? 299 GLN A CD   1 
ATOM   4545 O OE1  . GLN A 1 299 ? -6.97297  -22.71881 32.00710  1.000 31.85689  ? 299 GLN A OE1  1 
ATOM   4546 N NE2  . GLN A 1 299 ? -8.87008  -23.17947 30.90894  1.000 32.55742  ? 299 GLN A NE2  1 
ATOM   4547 H H    . GLN A 1 299 ? -12.25905 -24.98953 33.84223  1.000 48.27595  ? 299 GLN A H    1 
ATOM   4548 H HA   . GLN A 1 299 ? -9.94890  -26.20314 34.18194  1.000 48.59078  ? 299 GLN A HA   1 
ATOM   4549 H HB2  . GLN A 1 299 ? -10.33591 -24.71229 32.37383  1.000 42.87465  ? 299 GLN A HB2  1 
ATOM   4550 H HB3  . GLN A 1 299 ? -10.31941 -23.50681 33.40918  1.000 42.87465  ? 299 GLN A HB3  1 
ATOM   4551 H HG2  . GLN A 1 299 ? -8.08094  -23.94171 33.87692  1.000 40.68244  ? 299 GLN A HG2  1 
ATOM   4552 H HG3  . GLN A 1 299 ? -8.09833  -25.14291 32.83663  1.000 40.68244  ? 299 GLN A HG3  1 
ATOM   4553 H HE21 . GLN A 1 299 ? -9.60743  -23.62166 30.88969  1.000 39.05595  ? 299 GLN A HE21 1 
ATOM   4554 H HE22 . GLN A 1 299 ? -8.66928  -22.64985 30.26180  1.000 39.05595  ? 299 GLN A HE22 1 
ATOM   4555 N N    . CYS A 1 300 ? -10.73701 -24.13595 36.43685  1.000 40.59256  ? 300 CYS A N    1 
ATOM   4556 C CA   . CYS A 1 300 ? -10.35276 -23.61516 37.74219  1.000 40.51660  ? 300 CYS A CA   1 
ATOM   4557 C C    . CYS A 1 300 ? -10.62239 -24.59691 38.88020  1.000 43.38371  ? 300 CYS A C    1 
ATOM   4558 O O    . CYS A 1 300 ? -10.41618 -24.24132 40.04510  1.000 44.91665  ? 300 CYS A O    1 
ATOM   4559 C CB   . CYS A 1 300 ? -11.08125 -22.29641 38.01076  1.000 43.23960  ? 300 CYS A CB   1 
ATOM   4560 S SG   . CYS A 1 300 ? -10.57195 -20.94138 36.90909  1.000 44.19867  ? 300 CYS A SG   1 
ATOM   4561 H H    . CYS A 1 300 ? -11.55186 -23.96682 36.22001  1.000 48.69811  ? 300 CYS A H    1 
ATOM   4562 H HA   . CYS A 1 300 ? -9.39937  -23.43676 37.73199  1.000 48.60696  ? 300 CYS A HA   1 
ATOM   4563 H HB2  . CYS A 1 300 ? -12.03341 -22.43567 37.88867  1.000 51.87457  ? 300 CYS A HB2  1 
ATOM   4564 H HB3  . CYS A 1 300 ? -10.90059 -22.02053 38.92298  1.000 51.87457  ? 300 CYS A HB3  1 
ATOM   4565 H HG   . CYS A 1 300 ? -10.71256 -21.29045 35.76962  1.000 53.02546  ? 300 CYS A HG   1 
ATOM   4566 N N    . SER A 1 301 ? -11.06404 -25.82215 38.57183  1.000 44.04138  ? 301 SER A N    1 
ATOM   4567 C CA   . SER A 1 301 ? -11.35912 -26.82056 39.59062  1.000 44.71961  ? 301 SER A CA   1 
ATOM   4568 C C    . SER A 1 301 ? -10.74413 -28.18750 39.31007  1.000 48.22864  ? 301 SER A C    1 
ATOM   4569 O O    . SER A 1 301 ? -10.95446 -29.11272 40.10189  1.000 53.25960  ? 301 SER A O    1 
ATOM   4570 C CB   . SER A 1 301 ? -12.87892 -26.97823 39.75497  1.000 47.06549  ? 301 SER A CB   1 
ATOM   4571 O OG   . SER A 1 301 ? -13.19601 -28.12608 40.52439  1.000 61.49169  ? 301 SER A OG   1 
ATOM   4572 H H    . SER A 1 301 ? -11.20057 -26.09694 37.76844  1.000 52.83670  ? 301 SER A H    1 
ATOM   4573 H HA   . SER A 1 301 ? -10.99607 -26.50881 40.43437  1.000 53.65058  ? 301 SER A HA   1 
ATOM   4574 H HB2  . SER A 1 301 ? -13.22960 -26.19279 40.20329  1.000 56.46564  ? 301 SER A HB2  1 
ATOM   4575 H HB3  . SER A 1 301 ? -13.28228 -27.06707 38.87730  1.000 56.46564  ? 301 SER A HB3  1 
ATOM   4576 H HG   . SER A 1 301 ? -12.79035 -28.10025 41.25949  1.000 73.77707  ? 301 SER A HG   1 
ATOM   4577 N N    . GLY A 1 302 ? -10.00472 -28.34747 38.21438  1.000 47.16740  ? 302 GLY A N    1 
ATOM   4578 C CA   . GLY A 1 302 ? -9.25818  -29.56974 37.98820  1.000 46.14392  ? 302 GLY A CA   1 
ATOM   4579 C C    . GLY A 1 302 ? -10.07362 -30.76195 37.54566  1.000 49.62657  ? 302 GLY A C    1 
ATOM   4580 O O    . GLY A 1 302 ? -9.66630  -31.90165 37.78989  1.000 47.13211  ? 302 GLY A O    1 
ATOM   4581 H H    . GLY A 1 302 ? -9.92194  -27.76132 37.59054  1.000 56.58792  ? 302 GLY A H    1 
ATOM   4582 H HA2  . GLY A 1 302 ? -8.59202  -29.40099 37.30361  1.000 55.35975  ? 302 GLY A HA2  1 
ATOM   4583 H HA3  . GLY A 1 302 ? -8.80899  -29.81280 38.81285  1.000 55.35975  ? 302 GLY A HA3  1 
ATOM   4584 N N    . VAL A 1 303 ? -11.21663 -30.53766 36.89420  1.000 51.82708  ? 303 VAL A N    1 
ATOM   4585 C CA   . VAL A 1 303 ? -12.03567 -31.65256 36.43710  1.000 54.68599  ? 303 VAL A CA   1 
ATOM   4586 C C    . VAL A 1 303 ? -11.27850 -32.44613 35.38070  1.000 53.60849  ? 303 VAL A C    1 
ATOM   4587 O O    . VAL A 1 303 ? -10.65424 -31.87930 34.47409  1.000 49.92119  ? 303 VAL A O    1 
ATOM   4588 C CB   . VAL A 1 303 ? -13.38063 -31.13472 35.90009  1.000 54.47847  ? 303 VAL A CB   1 
ATOM   4589 C CG1  . VAL A 1 303 ? -14.13750 -32.24077 35.18311  1.000 46.66044  ? 303 VAL A CG1  1 
ATOM   4590 C CG2  . VAL A 1 303 ? -14.21850 -30.56108 37.04049  1.000 55.21353  ? 303 VAL A CG2  1 
ATOM   4591 H H    . VAL A 1 303 ? -11.53319 -29.75994 36.70832  1.000 62.17954  ? 303 VAL A H    1 
ATOM   4592 H HA   . VAL A 1 303 ? -12.21699 -32.24440 37.18393  1.000 65.61023  ? 303 VAL A HA   1 
ATOM   4593 H HB   . VAL A 1 303 ? -13.21046 -30.42734 35.25857  1.000 65.36121  ? 303 VAL A HB   1 
ATOM   4594 H HG11 . VAL A 1 303 ? -15.06086 -31.96738 35.06663  1.000 55.97957  ? 303 VAL A HG11 1 
ATOM   4595 H HG12 . VAL A 1 303 ? -13.72662 -32.39518 34.31810  1.000 55.97957  ? 303 VAL A HG12 1 
ATOM   4596 H HG13 . VAL A 1 303 ? -14.09679 -33.04914 35.71768  1.000 55.97957  ? 303 VAL A HG13 1 
ATOM   4597 H HG21 . VAL A 1 303 ? -13.66548 -30.49079 37.83430  1.000 66.24329  ? 303 VAL A HG21 1 
ATOM   4598 H HG22 . VAL A 1 303 ? -14.54214 -29.68336 36.78404  1.000 66.24329  ? 303 VAL A HG22 1 
ATOM   4599 H HG23 . VAL A 1 303 ? -14.96774 -31.15317 37.21069  1.000 66.24329  ? 303 VAL A HG23 1 
ATOM   4600 N N    . THR A 1 304 ? -11.32634 -33.77049 35.49863  1.000 57.18458  ? 304 THR A N    1 
ATOM   4601 C CA   . THR A 1 304 ? -10.63174 -34.65257 34.56218  1.000 50.40649  ? 304 THR A CA   1 
ATOM   4602 C C    . THR A 1 304 ? -11.62038 -35.58729 33.87232  1.000 47.29830  ? 304 THR A C    1 
ATOM   4603 O O    . THR A 1 304 ? -12.82773 -35.51085 34.10838  1.000 48.51326  ? 304 THR A O    1 
ATOM   4604 C CB   . THR A 1 304 ? -9.54929  -35.48748 35.27222  1.000 46.91287  ? 304 THR A CB   1 
ATOM   4605 H H    . THR A 1 304 ? -11.75681 -34.18640 36.11613  1.000 68.60855  ? 304 THR A H    1 
ATOM   4606 H HA   . THR A 1 304 ? -10.19418 -34.11898 33.88047  1.000 60.47484  ? 304 THR A HA   1 
HETATM 4607 C C7   . UED B 2 .   ? -13.96974 -21.99819 -0.39900  1.000 44.86035  ? 401 UED A C7   1 
HETATM 4608 O O8   . UED B 2 .   ? -14.69853 -23.16725 -0.76916  1.000 39.50002  ? 401 UED A O8   1 
HETATM 4609 C C9   . UED B 2 .   ? -14.99023 -24.13250 0.12748   1.000 37.79966  ? 401 UED A C9   1 
HETATM 4610 O O10  . UED B 2 .   ? -14.83800 -24.04202 1.34582   1.000 33.57288  ? 401 UED A O10  1 
HETATM 4611 C C1   . UED B 2 .   ? -12.47102 -22.23609 -0.53555  1.000 44.78546  ? 401 UED A C1   1 
HETATM 4612 C C2   . UED B 2 .   ? -11.98502 -23.40451 -1.13414  1.000 41.60558  ? 401 UED A C2   1 
HETATM 4613 C C3   . UED B 2 .   ? -10.60943 -23.60873 -1.25244  1.000 42.22054  ? 401 UED A C3   1 
HETATM 4614 C C4   . UED B 2 .   ? -9.71974  -22.64669 -0.77139  1.000 44.90473  ? 401 UED A C4   1 
HETATM 4615 C C5   . UED B 2 .   ? -10.19632 -21.48157 -0.17416  1.000 45.53108  ? 401 UED A C5   1 
HETATM 4616 C C6   . UED B 2 .   ? -11.57035 -21.27823 -0.05555  1.000 46.09146  ? 401 UED A C6   1 
HETATM 4617 N N11  . UED B 2 .   ? -15.48109 -25.25075 -0.53169  1.000 35.81900  ? 401 UED A N11  1 
HETATM 4618 C C12  . UED B 2 .   ? -15.49423 -26.55972 0.13953   1.000 32.12309  ? 401 UED A C12  1 
HETATM 4619 C C17  . UED B 2 .   ? -14.07747 -27.04362 0.53665   1.000 32.63408  ? 401 UED A C17  1 
HETATM 4620 O O18  . UED B 2 .   ? -13.14370 -26.96046 -0.26194  1.000 32.07765  ? 401 UED A O18  1 
HETATM 4621 C C13  . UED B 2 .   ? -16.19087 -27.60872 -0.76048  1.000 33.49358  ? 401 UED A C13  1 
HETATM 4622 C C14  . UED B 2 .   ? -17.66731 -27.30992 -1.12728  1.000 36.44132  ? 401 UED A C14  1 
HETATM 4623 C C15  . UED B 2 .   ? -18.38372 -26.43549 -0.07703  1.000 39.23671  ? 401 UED A C15  1 
HETATM 4624 C C16  . UED B 2 .   ? -18.44804 -28.61357 -1.40300  1.000 36.20593  ? 401 UED A C16  1 
HETATM 4625 N N19  . UED B 2 .   ? -13.95887 -27.54079 1.78333   1.000 29.19464  ? 401 UED A N19  1 
HETATM 4626 C C20  . UED B 2 .   ? -12.71284 -28.04879 2.37519   1.000 29.05057  ? 401 UED A C20  1 
HETATM 4627 C C21  . UED B 2 .   ? -12.87674 -29.52708 2.79504   1.000 28.96475  ? 401 UED A C21  1 
HETATM 4628 O O22  . UED B 2 .   ? -11.67093 -30.09432 3.27298   1.000 30.97701  ? 401 UED A O22  1 
HETATM 4629 C C24  . UED B 2 .   ? -12.21609 -27.12266 3.52264   1.000 27.49142  ? 401 UED A C24  1 
HETATM 4630 C C25  . UED B 2 .   ? -11.80287 -25.65537 3.10394   1.000 30.15491  ? 401 UED A C25  1 
HETATM 4631 C C26  . UED B 2 .   ? -10.64918 -25.61322 2.09751   1.000 33.89409  ? 401 UED A C26  1 
HETATM 4632 C C27  . UED B 2 .   ? -9.61098  -24.65905 2.64658   1.000 33.21736  ? 401 UED A C27  1 
HETATM 4633 N N28  . UED B 2 .   ? -9.98850  -24.38208 4.02472   1.000 32.10803  ? 401 UED A N28  1 
HETATM 4634 C C29  . UED B 2 .   ? -11.27288 -24.94257 4.34992   1.000 29.58318  ? 401 UED A C29  1 
HETATM 4635 O O30  . UED B 2 .   ? -11.78306 -24.84217 5.46013   1.000 29.66674  ? 401 UED A O30  1 
HETATM 4636 H H1   . UED B 2 .   ? -14.19917 -21.71812 0.63124   1.000 53.81946  ? 401 UED A H1   1 
HETATM 4637 H H2   . UED B 2 .   ? -14.26085 -21.15431 -1.02796  1.000 53.81946  ? 401 UED A H2   1 
HETATM 4638 H H3   . UED B 2 .   ? -12.67086 -24.15242 -1.50673  1.000 49.91374  ? 401 UED A H3   1 
HETATM 4639 H H4   . UED B 2 .   ? -10.23227 -24.50977 -1.71550  1.000 50.65169  ? 401 UED A H4   1 
HETATM 4640 H H5   . UED B 2 .   ? -8.65543  -22.80595 -0.86243  1.000 53.87272  ? 401 UED A H5   1 
HETATM 4641 H H6   . UED B 2 .   ? -9.50481  -20.73770 0.19604   1.000 54.62434  ? 401 UED A H6   1 
HETATM 4642 H H7   . UED B 2 .   ? -11.93768 -20.37361 0.41078   1.000 55.29680  ? 401 UED A H7   1 
HETATM 4643 H H8   . UED B 2 .   ? -15.83198 -25.17083 -1.47647  1.000 42.96985  ? 401 UED A H8   1 
HETATM 4644 H H9   . UED B 2 .   ? -16.08715 -26.46570 1.05290   1.000 38.53475  ? 401 UED A H9   1 
HETATM 4645 H H10  . UED B 2 .   ? -16.14042 -28.58314 -0.26792  1.000 40.17934  ? 401 UED A H10  1 
HETATM 4646 H H11  . UED B 2 .   ? -15.61416 -27.71908 -1.68237  1.000 40.17934  ? 401 UED A H11  1 
HETATM 4647 H H12  . UED B 2 .   ? -17.65305 -26.75021 -2.06365  1.000 43.71663  ? 401 UED A H12  1 
HETATM 4648 H H13  . UED B 2 .   ? -18.20506 -26.78783 0.93994   1.000 47.07110  ? 401 UED A H13  1 
HETATM 4649 H H14  . UED B 2 .   ? -19.46509 -26.42539 -0.22133  1.000 47.07110  ? 401 UED A H14  1 
HETATM 4650 H H15  . UED B 2 .   ? -18.05150 -25.39694 -0.11335  1.000 47.07110  ? 401 UED A H15  1 
HETATM 4651 H H16  . UED B 2 .   ? -19.43643 -28.43048 -1.82190  1.000 43.43416  ? 401 UED A H16  1 
HETATM 4652 H H17  . UED B 2 .   ? -17.93770 -29.26737 -2.10871  1.000 43.43416  ? 401 UED A H17  1 
HETATM 4653 H H18  . UED B 2 .   ? -18.60680 -29.20622 -0.50328  1.000 43.43416  ? 401 UED A H18  1 
HETATM 4654 H H19  . UED B 2 .   ? -14.77926 -27.57501 2.37145   1.000 35.02061  ? 401 UED A H19  1 
HETATM 4655 H H20  . UED B 2 .   ? -11.92837 -28.08450 1.61494   1.000 34.84772  ? 401 UED A H20  1 
HETATM 4656 H H21  . UED B 2 .   ? -11.36706 -27.60973 4.00676   1.000 32.97675  ? 401 UED A H21  1 
HETATM 4657 H H22  . UED B 2 .   ? -13.00123 -27.07158 4.27988   1.000 32.97675  ? 401 UED A H22  1 
HETATM 4658 H H23  . UED B 2 .   ? -12.63820 -25.07675 2.70680   1.000 36.17294  ? 401 UED A H23  1 
HETATM 4659 H H24  . UED B 2 .   ? -10.97502 -25.27211 1.11487   1.000 40.65995  ? 401 UED A H24  1 
HETATM 4660 H H25  . UED B 2 .   ? -10.19986 -26.59500 1.94807   1.000 40.65995  ? 401 UED A H25  1 
HETATM 4661 H H26  . UED B 2 .   ? -9.58665  -23.72359 2.08764   1.000 39.84788  ? 401 UED A H26  1 
HETATM 4662 H H27  . UED B 2 .   ? -8.61246  -25.09585 2.63030   1.000 39.84788  ? 401 UED A H27  1 
HETATM 4663 H H28  . UED B 2 .   ? -9.25810  -24.34803 4.72147   1.000 38.51668  ? 401 UED A H28  1 
HETATM 4664 H H31  . UED B 2 .   ? -11.37681 -30.74589 2.63433   1.000 37.15945  ? 401 UED A H31  1 
HETATM 4665 O O    . HOH C 3 .   ? -29.37293 -32.17023 13.32141  1.000 36.10137  ? 501 HOH A O    1 
HETATM 4666 O O    . HOH C 3 .   ? -11.99534 -20.09477 18.05534  1.000 42.82408  ? 502 HOH A O    1 
HETATM 4667 O O    . HOH C 3 .   ? -25.28748 -44.46279 -4.88686  1.000 31.83694  ? 503 HOH A O    1 
HETATM 4668 O O    . HOH C 3 .   ? -21.21521 -14.61472 15.88159  1.000 36.25745  ? 504 HOH A O    1 
HETATM 4669 O O    . HOH C 3 .   ? -14.89988 -20.21319 17.24791  1.000 30.28478  ? 505 HOH A O    1 
HETATM 4670 O O    . HOH C 3 .   ? -26.02548 -39.43918 11.14780  1.000 32.06458  ? 506 HOH A O    1 
HETATM 4671 O O    . HOH C 3 .   ? -7.50327  -35.20090 3.64892   1.000 29.44945  ? 507 HOH A O    1 
HETATM 4672 O O    . HOH C 3 .   ? -13.19199 -44.09000 -6.18918  1.000 37.30463  ? 508 HOH A O    1 
HETATM 4673 O O    . HOH C 3 .   ? -32.68937 -34.34999 -7.71205  1.000 45.23345  ? 509 HOH A O    1 
HETATM 4674 O O    . HOH C 3 .   ? -5.68815  -22.13616 37.17062  1.000 35.05653  ? 510 HOH A O    1 
HETATM 4675 O O    . HOH C 3 .   ? -18.56927 -25.64129 28.00968  1.000 33.63897  ? 511 HOH A O    1 
HETATM 4676 O O    . HOH C 3 .   ? -17.21393 -53.27852 -1.43372  1.000 29.70956  ? 512 HOH A O    1 
HETATM 4677 O O    . HOH C 3 .   ? -28.12899 -24.31718 6.06748   1.000 36.44944  ? 513 HOH A O    1 
HETATM 4678 O O    . HOH C 3 .   ? -28.93496 -13.36792 24.11781  1.000 36.21125  ? 514 HOH A O    1 
HETATM 4679 O O    . HOH C 3 .   ? -11.38840 -18.08184 10.92158  1.000 34.67917  ? 515 HOH A O    1 
HETATM 4680 O O    . HOH C 3 .   ? -18.35560 -3.06850  41.25848  1.000 37.37823  ? 516 HOH A O    1 
HETATM 4681 O O    . HOH C 3 .   ? -5.39818  -27.87283 10.21945  1.000 30.40113  ? 517 HOH A O    1 
HETATM 4682 O O    . HOH C 3 .   ? -15.93291 -27.41699 25.67951  1.000 32.30208  ? 518 HOH A O    1 
HETATM 4683 O O    . HOH C 3 .   ? -26.37481 -28.02929 1.72150   1.000 30.21893  ? 519 HOH A O    1 
HETATM 4684 O O    . HOH C 3 .   ? -11.21443 -35.16992 13.89397  1.000 25.48212  ? 520 HOH A O    1 
HETATM 4685 O O    . HOH C 3 .   ? -10.81292 -44.38971 20.43016  1.000 31.13829  ? 521 HOH A O    1 
HETATM 4686 O O    . HOH C 3 .   ? -8.96212  -43.56355 1.13779   1.000 29.59776  ? 522 HOH A O    1 
HETATM 4687 O O    . HOH C 3 .   ? -24.08468 -17.25260 -6.58541  1.000 48.00280  ? 523 HOH A O    1 
HETATM 4688 O O    . HOH C 3 .   ? -13.33494 -23.12671 25.94226  1.000 30.57182  ? 524 HOH A O    1 
HETATM 4689 O O    . HOH C 3 .   ? -14.58269 -36.87622 -5.93218  1.000 34.19821  ? 525 HOH A O    1 
HETATM 4690 O O    . HOH C 3 .   ? -20.25583 0.88224   34.71384  1.000 39.00736  ? 526 HOH A O    1 
HETATM 4691 O O    . HOH C 3 .   ? -4.25755  -22.30187 23.91105  1.000 33.81809  ? 527 HOH A O    1 
HETATM 4692 O O    . HOH C 3 .   ? -14.23842 -49.56160 -1.41817  1.000 34.77756  ? 528 HOH A O    1 
HETATM 4693 O O    . HOH C 3 .   ? -19.50880 -51.90249 -5.26959  1.000 30.42811  ? 529 HOH A O    1 
HETATM 4694 O O    . HOH C 3 .   ? -12.57981 -54.59609 5.91661   1.000 39.81354  ? 530 HOH A O    1 
HETATM 4695 O O    . HOH C 3 .   ? -28.48901 -32.34031 20.30145  1.000 32.29766  ? 531 HOH A O    1 
HETATM 4696 O O    . HOH C 3 .   ? -25.08110 -11.92792 41.06816  1.000 32.56485  ? 532 HOH A O    1 
HETATM 4697 O O    . HOH C 3 .   ? -14.86867 -16.19781 27.24690  1.000 25.87330  ? 533 HOH A O    1 
HETATM 4698 O O    . HOH C 3 .   ? -11.94675 -49.26738 0.82110   1.000 30.43647  ? 534 HOH A O    1 
HETATM 4699 O O    . HOH C 3 .   ? -26.58113 -4.68063  41.49617  1.000 31.43227  ? 535 HOH A O    1 
HETATM 4700 O O    . HOH C 3 .   ? -12.74172 -57.60849 4.62404   1.000 40.00560  ? 536 HOH A O    1 
HETATM 4701 O O    . HOH C 3 .   ? -21.19715 -54.24324 9.28144   1.000 31.50247  ? 537 HOH A O    1 
HETATM 4702 O O    . HOH C 3 .   ? -22.16533 -45.33043 14.22983  1.000 32.51003  ? 538 HOH A O    1 
HETATM 4703 O O    . HOH C 3 .   ? -17.97171 -15.08692 11.83249  1.000 33.00419  ? 539 HOH A O    1 
HETATM 4704 O O    . HOH C 3 .   ? -24.16170 -34.36990 15.94558  1.000 29.49299  ? 540 HOH A O    1 
HETATM 4705 O O    . HOH C 3 .   ? -27.85016 -33.26144 -12.51005 1.000 40.15367  ? 541 HOH A O    1 
HETATM 4706 O O    . HOH C 3 .   ? -20.96167 -19.78902 37.17609  1.000 37.12136  ? 542 HOH A O    1 
HETATM 4707 O O    . HOH C 3 .   ? -3.08207  -7.44546  34.35334  1.000 34.83138  ? 543 HOH A O    1 
HETATM 4708 O O    . HOH C 3 .   ? -16.92138 -13.48667 9.52293   1.000 41.86361  ? 544 HOH A O    1 
HETATM 4709 O O    . HOH C 3 .   ? -28.72862 -3.62646  40.04744  1.000 24.98438  ? 545 HOH A O    1 
HETATM 4710 O O    . HOH C 3 .   ? -27.35293 -17.12147 17.60681  1.000 36.01691  ? 546 HOH A O    1 
HETATM 4711 O O    . HOH C 3 .   ? -13.74279 -1.78500  34.01223  1.000 37.46288  ? 547 HOH A O    1 
HETATM 4712 O O    . HOH C 3 .   ? -20.52791 -31.71970 2.02417   1.000 23.45966  ? 548 HOH A O    1 
HETATM 4713 O O    . HOH C 3 .   ? -18.65693 -51.30817 18.13699  1.000 33.30990  ? 549 HOH A O    1 
HETATM 4714 O O    . HOH C 3 .   ? -28.02943 -31.38296 -4.17204  1.000 33.53852  ? 550 HOH A O    1 
HETATM 4715 O O    . HOH C 3 .   ? -16.71545 -55.83938 -1.10997  1.000 30.80389  ? 551 HOH A O    1 
HETATM 4716 O O    . HOH C 3 .   ? -21.47620 -23.77858 10.34336  1.000 27.05188  ? 552 HOH A O    1 
HETATM 4717 O O    . HOH C 3 .   ? -9.26187  -48.51616 14.93933  1.000 27.78655  ? 553 HOH A O    1 
HETATM 4718 O O    . HOH C 3 .   ? -21.59247 -23.10762 30.58050  1.000 34.68896  ? 554 HOH A O    1 
HETATM 4719 O O    . HOH C 3 .   ? -1.82458  1.38730   30.87416  1.000 35.59763  ? 555 HOH A O    1 
HETATM 4720 O O    . HOH C 3 .   ? -23.11133 1.94752   40.75052  1.000 32.58830  ? 556 HOH A O    1 
HETATM 4721 O O    . HOH C 3 .   ? -26.53931 -39.96250 19.50250  1.000 35.94022  ? 557 HOH A O    1 
HETATM 4722 O O    . HOH C 3 .   ? -22.005   1.906     43.112    1.000 38.36091  ? 558 HOH A O    1 
HETATM 4723 O O    . HOH C 3 .   ? -28.59456 -23.23653 12.52149  1.000 33.41571  ? 559 HOH A O    1 
HETATM 4724 O O    . HOH C 3 .   ? -14.33185 2.68225   40.50680  1.000 46.29524  ? 560 HOH A O    1 
HETATM 4725 O O    . HOH C 3 .   ? -20.37287 -31.79345 22.12635  1.000 29.95370  ? 561 HOH A O    1 
HETATM 4726 O O    . HOH C 3 .   ? -31.37313 -36.73075 3.87912   1.000 31.90362  ? 562 HOH A O    1 
HETATM 4727 O O    . HOH C 3 .   ? -15.57164 -44.70301 26.22633  1.000 38.29513  ? 563 HOH A O    1 
HETATM 4728 O O    . HOH C 3 .   ? -30.99128 -16.77035 27.15098  1.000 43.91649  ? 564 HOH A O    1 
HETATM 4729 O O    . HOH C 3 .   ? -18.74173 -20.16582 -0.73549  1.000 42.80832  ? 565 HOH A O    1 
HETATM 4730 O O    . HOH C 3 .   ? -22.72672 -46.58242 -9.91379  1.000 40.61176  ? 566 HOH A O    1 
HETATM 4731 O O    . HOH C 3 .   ? -20.17221 -36.05563 26.74814  1.000 41.01747  ? 567 HOH A O    1 
HETATM 4732 O O    . HOH C 3 .   ? -15.02687 -6.39107  22.92356  1.000 35.29175  ? 568 HOH A O    1 
HETATM 4733 O O    . HOH C 3 .   ? -9.44025  -18.70481 12.81867  1.000 34.22727  ? 569 HOH A O    1 
HETATM 4734 O O    . HOH C 3 .   ? -21.10904 -7.99676  44.86222  1.000 38.54524  ? 570 HOH A O    1 
HETATM 4735 O O    . HOH C 3 .   ? -13.63835 -9.04568  21.67187  1.000 39.10948  ? 571 HOH A O    1 
HETATM 4736 O O    . HOH C 3 .   ? -29.54608 -35.25886 1.67328   1.000 30.69406  ? 572 HOH A O    1 
HETATM 4737 O O    . HOH C 3 .   ? -25.80015 -49.13041 -0.29833  1.000 31.25398  ? 573 HOH A O    1 
HETATM 4738 O O    . HOH C 3 .   ? -5.75149  -0.25760  24.40822  1.000 41.50010  ? 574 HOH A O    1 
HETATM 4739 O O    . HOH C 3 .   ? -2.81664  -10.18057 32.15755  1.000 36.64275  ? 575 HOH A O    1 
HETATM 4740 O O    . HOH C 3 .   ? -4.68355  -19.56175 25.61015  1.000 31.28950  ? 576 HOH A O    1 
HETATM 4741 O O    . HOH C 3 .   ? -27.65988 -26.93054 4.04516   1.000 31.14551  ? 577 HOH A O    1 
HETATM 4742 O O    . HOH C 3 .   ? -14.63008 -12.48407 19.89202  1.000 41.35818  ? 578 HOH A O    1 
HETATM 4743 O O    . HOH C 3 .   ? -6.12974  -43.36928 9.75787   1.000 39.82839  ? 579 HOH A O    1 
HETATM 4744 O O    . HOH C 3 .   ? -33.11363 -4.38329  34.23828  1.000 34.28438  ? 580 HOH A O    1 
HETATM 4745 O O    . HOH C 3 .   ? -22.52876 -19.90954 26.72015  1.000 31.33187  ? 581 HOH A O    1 
HETATM 4746 O O    . HOH C 3 .   ? -10.87481 -24.08494 27.22545  1.000 29.88183  ? 582 HOH A O    1 
HETATM 4747 O O    . HOH C 3 .   ? -12.34868 -6.44775  23.17478  1.000 38.65287  ? 583 HOH A O    1 
HETATM 4748 O O    . HOH C 3 .   ? -25.16997 -51.75711 -0.82262  1.000 34.62761  ? 584 HOH A O    1 
HETATM 4749 O O    . HOH C 3 .   ? -24.04553 -32.20052 -10.33398 1.000 38.80868  ? 585 HOH A O    1 
HETATM 4750 O O    . HOH C 3 .   ? -23.17561 -50.29504 -4.18119  1.000 30.96201  ? 586 HOH A O    1 
HETATM 4751 O O    . HOH C 3 .   ? -16.98641 -58.85831 4.29274   1.000 37.68391  ? 587 HOH A O    1 
HETATM 4752 O O    . HOH C 3 .   ? -6.98325  -33.82004 0.16879   1.000 34.52576  ? 588 HOH A O    1 
HETATM 4753 O O    . HOH C 3 .   ? -28.42332 -24.87893 17.13068  1.000 40.72043  ? 589 HOH A O    1 
HETATM 4754 O O    . HOH C 3 .   ? -16.55527 -51.64308 19.15775  1.000 34.48850  ? 590 HOH A O    1 
HETATM 4755 O O    . HOH C 3 .   ? -19.83197 -26.25915 25.69804  1.000 34.23952  ? 591 HOH A O    1 
HETATM 4756 O O    . HOH C 3 .   ? -11.52580 -24.50309 30.02004  1.000 33.12518  ? 592 HOH A O    1 
HETATM 4757 O O    . HOH C 3 .   ? -7.07415  -15.16236 28.10576  1.000 33.63965  ? 593 HOH A O    1 
HETATM 4758 O O    . HOH C 3 .   ? -7.066    -24.645   22.312    1.000 31.96317  ? 594 HOH A O    1 
HETATM 4759 O O    . HOH C 3 .   ? -28.20906 -28.47317 6.23813   1.000 30.22737  ? 595 HOH A O    1 
HETATM 4760 O O    . HOH C 3 .   ? -29.17220 -42.11629 0.09344   1.000 31.56380  ? 596 HOH A O    1 
HETATM 4761 O O    . HOH C 3 .   ? -22.55313 -22.80936 35.30496  1.000 39.63965  ? 597 HOH A O    1 
HETATM 4762 O O    . HOH C 3 .   ? -14.88849 -52.04211 -0.60479  1.000 29.93564  ? 598 HOH A O    1 
HETATM 4763 O O    . HOH C 3 .   ? -26.42329 -9.54083  40.05555  1.000 28.77119  ? 599 HOH A O    1 
HETATM 4764 O O    . HOH C 3 .   ? -24.82737 -13.81045 26.12278  1.000 33.46936  ? 600 HOH A O    1 
HETATM 4765 O O    . HOH C 3 .   ? -22.33938 -45.25312 22.95119  1.000 34.31787  ? 601 HOH A O    1 
HETATM 4766 O O    . HOH C 3 .   ? -18.44357 -29.49729 27.84736  1.000 40.13147  ? 602 HOH A O    1 
HETATM 4767 O O    . HOH C 3 .   ? -3.21105  -16.74814 32.01199  1.000 36.68402  ? 603 HOH A O    1 
HETATM 4768 O O    . HOH C 3 .   ? -27.29996 4.80474   33.41811  1.000 38.88413  ? 604 HOH A O    1 
HETATM 4769 O O    . HOH C 3 .   ? -5.18376  -10.05258 22.37846  0.50  40.24384  ? 605 HOH A O    1 
HETATM 4770 O O    . HOH C 3 .   ? -2.13136  -5.10059  32.64189  1.000 35.69468  ? 606 HOH A O    1 
HETATM 4771 O O    . HOH C 3 .   ? -22.35780 -48.50855 -11.19785 1.000 51.25376  ? 607 HOH A O    1 
HETATM 4772 O O    . HOH C 3 .   ? -7.53339  -45.93458 14.06958  1.000 35.03028  ? 608 HOH A O    1 
HETATM 4773 O O    . HOH C 3 .   ? -28.70111 -29.95268 -1.82911  1.000 37.48289  ? 609 HOH A O    1 
HETATM 4774 O O    . HOH C 3 .   ? -10.31830 -57.30104 2.90621   1.000 37.94195  ? 610 HOH A O    1 
HETATM 4775 O O    . HOH C 3 .   ? -27.97748 -27.87883 -0.39195  1.000 35.75944  ? 611 HOH A O    1 
HETATM 4776 O O    . HOH C 3 .   ? -5.18376  -26.27275 22.37846  0.50  32.57451  ? 612 HOH A O    1 
HETATM 4777 O O    . HOH C 3 .   ? -27.36752 -41.43441 12.55311  1.000 42.42472  ? 613 HOH A O    1 
HETATM 4778 O O    . HOH C 3 .   ? -26.60339 -52.32636 1.38684   1.000 36.83068  ? 614 HOH A O    1 
HETATM 4779 O O    . HOH C 3 .   ? -22.88898 -56.20670 8.38689   1.000 39.30431  ? 615 HOH A O    1 
HETATM 4780 O O    . HOH C 3 .   ? -21.70063 -31.69243 24.51979  1.000 32.78487  ? 616 HOH A O    1 
HETATM 4781 O O    . HOH C 3 .   ? -30.96178 -37.14801 1.30286   1.000 37.04010  ? 617 HOH A O    1 
HETATM 4782 O O    . HOH C 3 .   ? -25.14508 -15.38417 24.25357  1.000 36.32680  ? 618 HOH A O    1 
HETATM 4783 O O    . HOH C 3 .   ? -24.64589 -18.97523 25.74374  1.000 37.86282  ? 619 HOH A O    1 
HETATM 4784 O O    . HOH C 3 .   ? -16.052   -60.459   -0.004    1.000 40.78816  ? 620 HOH A O    1 
HETATM 4785 O O    . HOH C 3 .   ? -12.39650 2.00297   41.58533  1.000 41.61014  ? 621 HOH A O    1 
HETATM 4786 O O    . HOH C 3 .   ? -22.43735 -52.17693 -5.36924  1.000 32.08167  ? 622 HOH A O    1 
HETATM 4787 O O    . HOH C 3 .   ? -18.625   -53.834   -3.573    1.000 28.33225  ? 623 HOH A O    1 
HETATM 4788 O O    . HOH C 3 .   ? -16.487   -59.964   -2.681    1.000 31.86180  ? 624 HOH A O    1 
HETATM 4789 O O    . HOH C 3 .   ? -25.806   -12.951   3.219     1.000 37.96519  ? 625 HOH A O    1 
HETATM 4790 O O    . HOH C 3 .   ? -14.85023 -12.24875 10.63888  1.000 41.80503  ? 626 HOH A O    1 
HETATM 4791 O O    . HOH C 3 .   ? -28.43391 -39.89901 18.03098  1.000 46.86845  ? 627 HOH A O    1 
HETATM 4792 O O    . HOH C 3 .   ? -5.18376  -20.40753 22.37846  0.50  34.45023  ? 628 HOH A O    1 
HETATM 4793 O O    . HOH C 3 .   ? -11.63454 -4.18130  24.09040  1.000 36.63951  ? 629 HOH A O    1 
HETATM 4794 O O    . HOH C 3 .   ? -13.83404 3.44918   37.66149  1.000 41.47196  ? 630 HOH A O    1 
# 
