data_9BOC
# 
_entry.id   9BOC 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BOC         pdb_00009boc 10.2210/pdb9boc/pdb 
WWPDB D_1000283416 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-12 ? 
2 'Structure model' 1 1 2025-03-12 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
_pdbx_audit_revision_category.ordinal             1 
_pdbx_audit_revision_category.revision_ordinal    2 
_pdbx_audit_revision_category.data_content_type   'Structure model' 
_pdbx_audit_revision_category.category            citation 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
5 2 'Structure model' '_citation.title'                   
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BOC 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-03 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              karen.anderson@yale.edu 
_pdbx_contact_author.name_first         Karen 
_pdbx_contact_author.name_last          Anderson 
_pdbx_contact_author.name_mi            S 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-3433-0780 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Papini, C.'     1 0000-0002-6098-4959 
'Kenneson, J.'   2 ?                   
'Anderson, K.S.' 3 0000-0003-3433-0780 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Acs Bio Med Chem Au' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2694-2437 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            5 
_citation.language                  ? 
_citation.page_first                215 
_citation.page_last                 226 
_citation.title                     
'Exploring Possible Drug-Resistant Variants of SARS-CoV-2 Main Protease (M pro ) with Noncovalent Preclinical Candidate, Mpro61.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acsbiomedchemau.4c00109 
_citation.pdbx_database_id_PubMed   39990941 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Kenneson, J.R.'  1 ? 
primary 'Papini, C.'      2 ? 
primary 'Tang, S.'        3 ? 
primary 'Huynh, K.'       4 ? 
primary 'Zhang, C.H.'     5 ? 
primary 'Jorgensen, W.L.' 6 ? 
primary 'Anderson, K.S.'  7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '3C-like proteinase nsp5'                                                                              33859.562 
1   3.4.22.69 ? ? ? 
2 non-polymer syn 'N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide' 405.488   
1   ?         ? ? ? 
3 water       nat water                                                                                                  18.015    
230 ?         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMFNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMFNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide' UED 
3 water                                                                                                  HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   GLY n 
1 3   PHE n 
1 4   ARG n 
1 5   LYS n 
1 6   MET n 
1 7   ALA n 
1 8   PHE n 
1 9   PRO n 
1 10  SER n 
1 11  GLY n 
1 12  LYS n 
1 13  VAL n 
1 14  GLU n 
1 15  GLY n 
1 16  CYS n 
1 17  MET n 
1 18  VAL n 
1 19  GLN n 
1 20  VAL n 
1 21  THR n 
1 22  CYS n 
1 23  GLY n 
1 24  THR n 
1 25  THR n 
1 26  THR n 
1 27  LEU n 
1 28  ASN n 
1 29  GLY n 
1 30  LEU n 
1 31  TRP n 
1 32  LEU n 
1 33  ASP n 
1 34  ASP n 
1 35  VAL n 
1 36  VAL n 
1 37  TYR n 
1 38  CYS n 
1 39  PRO n 
1 40  ARG n 
1 41  HIS n 
1 42  VAL n 
1 43  ILE n 
1 44  CYS n 
1 45  THR n 
1 46  SER n 
1 47  GLU n 
1 48  ASP n 
1 49  MET n 
1 50  PHE n 
1 51  ASN n 
1 52  PRO n 
1 53  ASN n 
1 54  TYR n 
1 55  GLU n 
1 56  ASP n 
1 57  LEU n 
1 58  LEU n 
1 59  ILE n 
1 60  ARG n 
1 61  LYS n 
1 62  SER n 
1 63  ASN n 
1 64  HIS n 
1 65  ASN n 
1 66  PHE n 
1 67  LEU n 
1 68  VAL n 
1 69  GLN n 
1 70  ALA n 
1 71  GLY n 
1 72  ASN n 
1 73  VAL n 
1 74  GLN n 
1 75  LEU n 
1 76  ARG n 
1 77  VAL n 
1 78  ILE n 
1 79  GLY n 
1 80  HIS n 
1 81  SER n 
1 82  MET n 
1 83  GLN n 
1 84  ASN n 
1 85  CYS n 
1 86  VAL n 
1 87  LEU n 
1 88  LYS n 
1 89  LEU n 
1 90  LYS n 
1 91  VAL n 
1 92  ASP n 
1 93  THR n 
1 94  ALA n 
1 95  ASN n 
1 96  PRO n 
1 97  LYS n 
1 98  THR n 
1 99  PRO n 
1 100 LYS n 
1 101 TYR n 
1 102 LYS n 
1 103 PHE n 
1 104 VAL n 
1 105 ARG n 
1 106 ILE n 
1 107 GLN n 
1 108 PRO n 
1 109 GLY n 
1 110 GLN n 
1 111 THR n 
1 112 PHE n 
1 113 SER n 
1 114 VAL n 
1 115 LEU n 
1 116 ALA n 
1 117 CYS n 
1 118 TYR n 
1 119 ASN n 
1 120 GLY n 
1 121 SER n 
1 122 PRO n 
1 123 SER n 
1 124 GLY n 
1 125 VAL n 
1 126 TYR n 
1 127 GLN n 
1 128 CYS n 
1 129 ALA n 
1 130 MET n 
1 131 ARG n 
1 132 PRO n 
1 133 ASN n 
1 134 PHE n 
1 135 THR n 
1 136 ILE n 
1 137 LYS n 
1 138 GLY n 
1 139 SER n 
1 140 PHE n 
1 141 LEU n 
1 142 ASN n 
1 143 GLY n 
1 144 SER n 
1 145 CYS n 
1 146 GLY n 
1 147 SER n 
1 148 VAL n 
1 149 GLY n 
1 150 PHE n 
1 151 ASN n 
1 152 ILE n 
1 153 ASP n 
1 154 TYR n 
1 155 ASP n 
1 156 CYS n 
1 157 VAL n 
1 158 SER n 
1 159 PHE n 
1 160 CYS n 
1 161 TYR n 
1 162 MET n 
1 163 HIS n 
1 164 HIS n 
1 165 MET n 
1 166 GLU n 
1 167 LEU n 
1 168 PRO n 
1 169 THR n 
1 170 GLY n 
1 171 VAL n 
1 172 HIS n 
1 173 ALA n 
1 174 GLY n 
1 175 THR n 
1 176 ASP n 
1 177 LEU n 
1 178 GLU n 
1 179 GLY n 
1 180 ASN n 
1 181 PHE n 
1 182 TYR n 
1 183 GLY n 
1 184 PRO n 
1 185 PHE n 
1 186 VAL n 
1 187 ASP n 
1 188 ARG n 
1 189 GLN n 
1 190 THR n 
1 191 ALA n 
1 192 GLN n 
1 193 ALA n 
1 194 ALA n 
1 195 GLY n 
1 196 THR n 
1 197 ASP n 
1 198 THR n 
1 199 THR n 
1 200 ILE n 
1 201 THR n 
1 202 VAL n 
1 203 ASN n 
1 204 VAL n 
1 205 LEU n 
1 206 ALA n 
1 207 TRP n 
1 208 LEU n 
1 209 TYR n 
1 210 ALA n 
1 211 ALA n 
1 212 VAL n 
1 213 ILE n 
1 214 ASN n 
1 215 GLY n 
1 216 ASP n 
1 217 ARG n 
1 218 TRP n 
1 219 PHE n 
1 220 LEU n 
1 221 ASN n 
1 222 ARG n 
1 223 PHE n 
1 224 THR n 
1 225 THR n 
1 226 THR n 
1 227 LEU n 
1 228 ASN n 
1 229 ASP n 
1 230 PHE n 
1 231 ASN n 
1 232 LEU n 
1 233 VAL n 
1 234 ALA n 
1 235 MET n 
1 236 LYS n 
1 237 TYR n 
1 238 ASN n 
1 239 TYR n 
1 240 GLU n 
1 241 PRO n 
1 242 LEU n 
1 243 THR n 
1 244 GLN n 
1 245 ASP n 
1 246 HIS n 
1 247 VAL n 
1 248 ASP n 
1 249 ILE n 
1 250 LEU n 
1 251 GLY n 
1 252 PRO n 
1 253 LEU n 
1 254 SER n 
1 255 ALA n 
1 256 GLN n 
1 257 THR n 
1 258 GLY n 
1 259 ILE n 
1 260 ALA n 
1 261 VAL n 
1 262 LEU n 
1 263 ASP n 
1 264 MET n 
1 265 CYS n 
1 266 ALA n 
1 267 SER n 
1 268 LEU n 
1 269 LYS n 
1 270 GLU n 
1 271 LEU n 
1 272 LEU n 
1 273 GLN n 
1 274 ASN n 
1 275 GLY n 
1 276 MET n 
1 277 ASN n 
1 278 GLY n 
1 279 ARG n 
1 280 THR n 
1 281 ILE n 
1 282 LEU n 
1 283 GLY n 
1 284 SER n 
1 285 ALA n 
1 286 LEU n 
1 287 LEU n 
1 288 GLU n 
1 289 ASP n 
1 290 GLU n 
1 291 PHE n 
1 292 THR n 
1 293 PRO n 
1 294 PHE n 
1 295 ASP n 
1 296 VAL n 
1 297 VAL n 
1 298 ARG n 
1 299 GLN n 
1 300 CYS n 
1 301 SER n 
1 302 GLY n 
1 303 VAL n 
1 304 THR n 
1 305 PHE n 
1 306 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   306 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'rep, 1a-1b' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                                                                                ? 
'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                                                                               ? 
'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                                                                             ? 
'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                                                                        ? 
'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE                                                                                               ? 
'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE                                                                                              ? 
'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                                                                        ? 
'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                                                                                ? 
'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                                                                                              ? 
'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                                                                                  ? 
'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                                                                             ? 
'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                                                                                ? 
'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                                                                                 ? 
'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                                                                                             ? 
'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE                                                                                          ? 
'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                                                                                                ? 
'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                                                                                 ? 
'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                                                                                              ? 
'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                                                                             ? 
'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                                                                               ? 
'C9 H11 N O3'    181.189 
UED non-polymer         . 'N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide' 
'GC373 bound form, GC376 bound form' 'C21 H31 N3 O5'  405.488 
VAL 'L-peptide linking' y VALINE                                                                                                 ? 
'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   1   1   SER SER A . n 
A 1 2   GLY 2   2   2   GLY GLY A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   ARG 4   4   4   ARG ARG A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   MET 6   6   6   MET MET A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   PRO 9   9   9   PRO PRO A . n 
A 1 10  SER 10  10  10  SER SER A . n 
A 1 11  GLY 11  11  11  GLY GLY A . n 
A 1 12  LYS 12  12  12  LYS LYS A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  GLY 15  15  15  GLY GLY A . n 
A 1 16  CYS 16  16  16  CYS CYS A . n 
A 1 17  MET 17  17  17  MET MET A . n 
A 1 18  VAL 18  18  18  VAL VAL A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  THR 21  21  21  THR THR A . n 
A 1 22  CYS 22  22  22  CYS CYS A . n 
A 1 23  GLY 23  23  23  GLY GLY A . n 
A 1 24  THR 24  24  24  THR THR A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  THR 26  26  26  THR THR A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  ASN 28  28  28  ASN ASN A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  TRP 31  31  31  TRP TRP A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  ASP 33  33  33  ASP ASP A . n 
A 1 34  ASP 34  34  34  ASP ASP A . n 
A 1 35  VAL 35  35  35  VAL VAL A . n 
A 1 36  VAL 36  36  36  VAL VAL A . n 
A 1 37  TYR 37  37  37  TYR TYR A . n 
A 1 38  CYS 38  38  38  CYS CYS A . n 
A 1 39  PRO 39  39  39  PRO PRO A . n 
A 1 40  ARG 40  40  40  ARG ARG A . n 
A 1 41  HIS 41  41  41  HIS HIS A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  ILE 43  43  43  ILE ILE A . n 
A 1 44  CYS 44  44  44  CYS CYS A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  SER 46  46  46  SER SER A . n 
A 1 47  GLU 47  47  47  GLU GLU A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  MET 49  49  49  MET MET A . n 
A 1 50  PHE 50  50  50  PHE PHE A . n 
A 1 51  ASN 51  51  51  ASN ASN A . n 
A 1 52  PRO 52  52  52  PRO PRO A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  TYR 54  54  54  TYR TYR A . n 
A 1 55  GLU 55  55  55  GLU GLU A . n 
A 1 56  ASP 56  56  56  ASP ASP A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  ILE 59  59  59  ILE ILE A . n 
A 1 60  ARG 60  60  60  ARG ARG A . n 
A 1 61  LYS 61  61  61  LYS LYS A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  ASN 63  63  63  ASN ASN A . n 
A 1 64  HIS 64  64  64  HIS HIS A . n 
A 1 65  ASN 65  65  65  ASN ASN A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  GLN 69  69  69  GLN GLN A . n 
A 1 70  ALA 70  70  70  ALA ALA A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  ASN 72  72  72  ASN ASN A . n 
A 1 73  VAL 73  73  73  VAL VAL A . n 
A 1 74  GLN 74  74  74  GLN GLN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  ARG 76  76  76  ARG ARG A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  GLY 79  79  79  GLY GLY A . n 
A 1 80  HIS 80  80  80  HIS HIS A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  MET 82  82  82  MET MET A . n 
A 1 83  GLN 83  83  83  GLN GLN A . n 
A 1 84  ASN 84  84  84  ASN ASN A . n 
A 1 85  CYS 85  85  85  CYS CYS A . n 
A 1 86  VAL 86  86  86  VAL VAL A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  LYS 88  88  88  LYS LYS A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  LYS 90  90  90  LYS LYS A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  ASP 92  92  92  ASP ASP A . n 
A 1 93  THR 93  93  93  THR THR A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  PRO 96  96  96  PRO PRO A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  PRO 99  99  99  PRO PRO A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 TYR 101 101 101 TYR TYR A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 PHE 103 103 103 PHE PHE A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 ARG 105 105 105 ARG ARG A . n 
A 1 106 ILE 106 106 106 ILE ILE A . n 
A 1 107 GLN 107 107 107 GLN GLN A . n 
A 1 108 PRO 108 108 108 PRO PRO A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 GLN 110 110 110 GLN GLN A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 PHE 112 112 112 PHE PHE A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 CYS 117 117 117 CYS CYS A . n 
A 1 118 TYR 118 118 118 TYR TYR A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 SER 123 123 123 SER SER A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 MET 130 130 130 MET MET A . n 
A 1 131 ARG 131 131 131 ARG ARG A . n 
A 1 132 PRO 132 132 132 PRO PRO A . n 
A 1 133 ASN 133 133 133 ASN ASN A . n 
A 1 134 PHE 134 134 134 PHE PHE A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 LYS 137 137 137 LYS LYS A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 PHE 140 140 140 PHE PHE A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 ASN 142 142 142 ASN ASN A . n 
A 1 143 GLY 143 143 143 GLY GLY A . n 
A 1 144 SER 144 144 144 SER SER A . n 
A 1 145 CYS 145 145 145 CYS CYS A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 GLY 149 149 149 GLY GLY A . n 
A 1 150 PHE 150 150 150 PHE PHE A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 ILE 152 152 152 ILE ILE A . n 
A 1 153 ASP 153 153 153 ASP ASP A . n 
A 1 154 TYR 154 154 154 TYR TYR A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 CYS 156 156 156 CYS CYS A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 SER 158 158 158 SER SER A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 CYS 160 160 160 CYS CYS A . n 
A 1 161 TYR 161 161 161 TYR TYR A . n 
A 1 162 MET 162 162 162 MET MET A . n 
A 1 163 HIS 163 163 163 HIS HIS A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 MET 165 165 165 MET MET A . n 
A 1 166 GLU 166 166 166 GLU GLU A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 PRO 168 168 168 PRO PRO A . n 
A 1 169 THR 169 169 169 THR THR A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 VAL 171 171 171 VAL VAL A . n 
A 1 172 HIS 172 172 172 HIS HIS A . n 
A 1 173 ALA 173 173 173 ALA ALA A . n 
A 1 174 GLY 174 174 174 GLY GLY A . n 
A 1 175 THR 175 175 175 THR THR A . n 
A 1 176 ASP 176 176 176 ASP ASP A . n 
A 1 177 LEU 177 177 177 LEU LEU A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 TYR 182 182 182 TYR TYR A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 VAL 186 186 186 VAL VAL A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 GLN 189 189 189 GLN GLN A . n 
A 1 190 THR 190 190 190 THR THR A . n 
A 1 191 ALA 191 191 191 ALA ALA A . n 
A 1 192 GLN 192 192 192 GLN GLN A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 THR 196 196 196 THR THR A . n 
A 1 197 ASP 197 197 197 ASP ASP A . n 
A 1 198 THR 198 198 198 THR THR A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 ILE 200 200 200 ILE ILE A . n 
A 1 201 THR 201 201 201 THR THR A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 ALA 206 206 206 ALA ALA A . n 
A 1 207 TRP 207 207 207 TRP TRP A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ALA 210 210 210 ALA ALA A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ASN 214 214 214 ASN ASN A . n 
A 1 215 GLY 215 215 215 GLY GLY A . n 
A 1 216 ASP 216 216 216 ASP ASP A . n 
A 1 217 ARG 217 217 217 ARG ARG A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 ASN 221 221 221 ASN ASN A . n 
A 1 222 ARG 222 222 222 ARG ARG A . n 
A 1 223 PHE 223 223 223 PHE PHE A . n 
A 1 224 THR 224 224 224 THR THR A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 THR 226 226 226 THR THR A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 ASN 228 228 228 ASN ASN A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 PHE 230 230 230 PHE PHE A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 VAL 233 233 233 VAL VAL A . n 
A 1 234 ALA 234 234 234 ALA ALA A . n 
A 1 235 MET 235 235 235 MET MET A . n 
A 1 236 LYS 236 236 236 LYS LYS A . n 
A 1 237 TYR 237 237 237 TYR TYR A . n 
A 1 238 ASN 238 238 238 ASN ASN A . n 
A 1 239 TYR 239 239 239 TYR TYR A . n 
A 1 240 GLU 240 240 240 GLU GLU A . n 
A 1 241 PRO 241 241 241 PRO PRO A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 THR 243 243 243 THR THR A . n 
A 1 244 GLN 244 244 244 GLN GLN A . n 
A 1 245 ASP 245 245 245 ASP ASP A . n 
A 1 246 HIS 246 246 246 HIS HIS A . n 
A 1 247 VAL 247 247 247 VAL VAL A . n 
A 1 248 ASP 248 248 248 ASP ASP A . n 
A 1 249 ILE 249 249 249 ILE ILE A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 PRO 252 252 252 PRO PRO A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 SER 254 254 254 SER SER A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 THR 257 257 257 THR THR A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 ILE 259 259 259 ILE ILE A . n 
A 1 260 ALA 260 260 260 ALA ALA A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 LEU 262 262 262 LEU LEU A . n 
A 1 263 ASP 263 263 263 ASP ASP A . n 
A 1 264 MET 264 264 264 MET MET A . n 
A 1 265 CYS 265 265 265 CYS CYS A . n 
A 1 266 ALA 266 266 266 ALA ALA A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 LYS 269 269 269 LYS LYS A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 LEU 271 271 271 LEU LEU A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 ASN 274 274 274 ASN ASN A . n 
A 1 275 GLY 275 275 275 GLY GLY A . n 
A 1 276 MET 276 276 276 MET MET A . n 
A 1 277 ASN 277 277 277 ASN ASN A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 ARG 279 279 279 ARG ARG A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 ILE 281 281 281 ILE ILE A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 GLY 283 283 283 GLY GLY A . n 
A 1 284 SER 284 284 284 SER SER A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 LEU 286 286 286 LEU LEU A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 ASP 289 289 289 ASP ASP A . n 
A 1 290 GLU 290 290 290 GLU GLU A . n 
A 1 291 PHE 291 291 291 PHE PHE A . n 
A 1 292 THR 292 292 292 THR THR A . n 
A 1 293 PRO 293 293 293 PRO PRO A . n 
A 1 294 PHE 294 294 294 PHE PHE A . n 
A 1 295 ASP 295 295 295 ASP ASP A . n 
A 1 296 VAL 296 296 296 VAL VAL A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 GLN 299 299 299 GLN GLN A . n 
A 1 300 CYS 300 300 300 CYS CYS A . n 
A 1 301 SER 301 301 301 SER SER A . n 
A 1 302 GLY 302 302 302 GLY GLY A . n 
A 1 303 VAL 303 303 303 VAL VAL A . n 
A 1 304 THR 304 304 304 THR THR A . n 
A 1 305 PHE 305 305 ?   ?   ?   A . n 
A 1 306 GLN 306 306 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        UED 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   UED 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 UED 1   401 999 UED GCA A . 
C 3 HOH 1   501 97  HOH HOH A . 
C 3 HOH 2   502 125 HOH HOH A . 
C 3 HOH 3   503 65  HOH HOH A . 
C 3 HOH 4   504 227 HOH HOH A . 
C 3 HOH 5   505 118 HOH HOH A . 
C 3 HOH 6   506 4   HOH HOH A . 
C 3 HOH 7   507 170 HOH HOH A . 
C 3 HOH 8   508 233 HOH HOH A . 
C 3 HOH 9   509 205 HOH HOH A . 
C 3 HOH 10  510 235 HOH HOH A . 
C 3 HOH 11  511 96  HOH HOH A . 
C 3 HOH 12  512 113 HOH HOH A . 
C 3 HOH 13  513 122 HOH HOH A . 
C 3 HOH 14  514 54  HOH HOH A . 
C 3 HOH 15  515 31  HOH HOH A . 
C 3 HOH 16  516 5   HOH HOH A . 
C 3 HOH 17  517 121 HOH HOH A . 
C 3 HOH 18  518 48  HOH HOH A . 
C 3 HOH 19  519 169 HOH HOH A . 
C 3 HOH 20  520 66  HOH HOH A . 
C 3 HOH 21  521 130 HOH HOH A . 
C 3 HOH 22  522 88  HOH HOH A . 
C 3 HOH 23  523 165 HOH HOH A . 
C 3 HOH 24  524 104 HOH HOH A . 
C 3 HOH 25  525 128 HOH HOH A . 
C 3 HOH 26  526 114 HOH HOH A . 
C 3 HOH 27  527 196 HOH HOH A . 
C 3 HOH 28  528 203 HOH HOH A . 
C 3 HOH 29  529 109 HOH HOH A . 
C 3 HOH 30  530 75  HOH HOH A . 
C 3 HOH 31  531 63  HOH HOH A . 
C 3 HOH 32  532 101 HOH HOH A . 
C 3 HOH 33  533 194 HOH HOH A . 
C 3 HOH 34  534 20  HOH HOH A . 
C 3 HOH 35  535 38  HOH HOH A . 
C 3 HOH 36  536 106 HOH HOH A . 
C 3 HOH 37  537 159 HOH HOH A . 
C 3 HOH 38  538 15  HOH HOH A . 
C 3 HOH 39  539 140 HOH HOH A . 
C 3 HOH 40  540 22  HOH HOH A . 
C 3 HOH 41  541 16  HOH HOH A . 
C 3 HOH 42  542 10  HOH HOH A . 
C 3 HOH 43  543 108 HOH HOH A . 
C 3 HOH 44  544 229 HOH HOH A . 
C 3 HOH 45  545 173 HOH HOH A . 
C 3 HOH 46  546 8   HOH HOH A . 
C 3 HOH 47  547 178 HOH HOH A . 
C 3 HOH 48  548 209 HOH HOH A . 
C 3 HOH 49  549 123 HOH HOH A . 
C 3 HOH 50  550 207 HOH HOH A . 
C 3 HOH 51  551 13  HOH HOH A . 
C 3 HOH 52  552 33  HOH HOH A . 
C 3 HOH 53  553 71  HOH HOH A . 
C 3 HOH 54  554 61  HOH HOH A . 
C 3 HOH 55  555 232 HOH HOH A . 
C 3 HOH 56  556 58  HOH HOH A . 
C 3 HOH 57  557 183 HOH HOH A . 
C 3 HOH 58  558 59  HOH HOH A . 
C 3 HOH 59  559 157 HOH HOH A . 
C 3 HOH 60  560 100 HOH HOH A . 
C 3 HOH 61  561 73  HOH HOH A . 
C 3 HOH 62  562 156 HOH HOH A . 
C 3 HOH 63  563 116 HOH HOH A . 
C 3 HOH 64  564 202 HOH HOH A . 
C 3 HOH 65  565 147 HOH HOH A . 
C 3 HOH 66  566 84  HOH HOH A . 
C 3 HOH 67  567 180 HOH HOH A . 
C 3 HOH 68  568 80  HOH HOH A . 
C 3 HOH 69  569 142 HOH HOH A . 
C 3 HOH 70  570 72  HOH HOH A . 
C 3 HOH 71  571 231 HOH HOH A . 
C 3 HOH 72  572 174 HOH HOH A . 
C 3 HOH 73  573 9   HOH HOH A . 
C 3 HOH 74  574 62  HOH HOH A . 
C 3 HOH 75  575 136 HOH HOH A . 
C 3 HOH 76  576 134 HOH HOH A . 
C 3 HOH 77  577 135 HOH HOH A . 
C 3 HOH 78  578 184 HOH HOH A . 
C 3 HOH 79  579 98  HOH HOH A . 
C 3 HOH 80  580 25  HOH HOH A . 
C 3 HOH 81  581 41  HOH HOH A . 
C 3 HOH 82  582 228 HOH HOH A . 
C 3 HOH 83  583 89  HOH HOH A . 
C 3 HOH 84  584 14  HOH HOH A . 
C 3 HOH 85  585 45  HOH HOH A . 
C 3 HOH 86  586 2   HOH HOH A . 
C 3 HOH 87  587 141 HOH HOH A . 
C 3 HOH 88  588 28  HOH HOH A . 
C 3 HOH 89  589 46  HOH HOH A . 
C 3 HOH 90  590 51  HOH HOH A . 
C 3 HOH 91  591 12  HOH HOH A . 
C 3 HOH 92  592 153 HOH HOH A . 
C 3 HOH 93  593 195 HOH HOH A . 
C 3 HOH 94  594 218 HOH HOH A . 
C 3 HOH 95  595 117 HOH HOH A . 
C 3 HOH 96  596 91  HOH HOH A . 
C 3 HOH 97  597 68  HOH HOH A . 
C 3 HOH 98  598 211 HOH HOH A . 
C 3 HOH 99  599 32  HOH HOH A . 
C 3 HOH 100 600 181 HOH HOH A . 
C 3 HOH 101 601 230 HOH HOH A . 
C 3 HOH 102 602 27  HOH HOH A . 
C 3 HOH 103 603 55  HOH HOH A . 
C 3 HOH 104 604 144 HOH HOH A . 
C 3 HOH 105 605 17  HOH HOH A . 
C 3 HOH 106 606 35  HOH HOH A . 
C 3 HOH 107 607 241 HOH HOH A . 
C 3 HOH 108 608 226 HOH HOH A . 
C 3 HOH 109 609 124 HOH HOH A . 
C 3 HOH 110 610 49  HOH HOH A . 
C 3 HOH 111 611 107 HOH HOH A . 
C 3 HOH 112 612 215 HOH HOH A . 
C 3 HOH 113 613 197 HOH HOH A . 
C 3 HOH 114 614 1   HOH HOH A . 
C 3 HOH 115 615 139 HOH HOH A . 
C 3 HOH 116 616 102 HOH HOH A . 
C 3 HOH 117 617 79  HOH HOH A . 
C 3 HOH 118 618 200 HOH HOH A . 
C 3 HOH 119 619 50  HOH HOH A . 
C 3 HOH 120 620 23  HOH HOH A . 
C 3 HOH 121 621 86  HOH HOH A . 
C 3 HOH 122 622 126 HOH HOH A . 
C 3 HOH 123 623 11  HOH HOH A . 
C 3 HOH 124 624 18  HOH HOH A . 
C 3 HOH 125 625 172 HOH HOH A . 
C 3 HOH 126 626 111 HOH HOH A . 
C 3 HOH 127 627 201 HOH HOH A . 
C 3 HOH 128 628 190 HOH HOH A . 
C 3 HOH 129 629 110 HOH HOH A . 
C 3 HOH 130 630 43  HOH HOH A . 
C 3 HOH 131 631 152 HOH HOH A . 
C 3 HOH 132 632 188 HOH HOH A . 
C 3 HOH 133 633 149 HOH HOH A . 
C 3 HOH 134 634 29  HOH HOH A . 
C 3 HOH 135 635 83  HOH HOH A . 
C 3 HOH 136 636 26  HOH HOH A . 
C 3 HOH 137 637 132 HOH HOH A . 
C 3 HOH 138 638 160 HOH HOH A . 
C 3 HOH 139 639 44  HOH HOH A . 
C 3 HOH 140 640 206 HOH HOH A . 
C 3 HOH 141 641 60  HOH HOH A . 
C 3 HOH 142 642 47  HOH HOH A . 
C 3 HOH 143 643 187 HOH HOH A . 
C 3 HOH 144 644 6   HOH HOH A . 
C 3 HOH 145 645 112 HOH HOH A . 
C 3 HOH 146 646 212 HOH HOH A . 
C 3 HOH 147 647 30  HOH HOH A . 
C 3 HOH 148 648 24  HOH HOH A . 
C 3 HOH 149 649 81  HOH HOH A . 
C 3 HOH 150 650 53  HOH HOH A . 
C 3 HOH 151 651 64  HOH HOH A . 
C 3 HOH 152 652 189 HOH HOH A . 
C 3 HOH 153 653 133 HOH HOH A . 
C 3 HOH 154 654 115 HOH HOH A . 
C 3 HOH 155 655 204 HOH HOH A . 
C 3 HOH 156 656 161 HOH HOH A . 
C 3 HOH 157 657 138 HOH HOH A . 
C 3 HOH 158 658 77  HOH HOH A . 
C 3 HOH 159 659 225 HOH HOH A . 
C 3 HOH 160 660 57  HOH HOH A . 
C 3 HOH 161 661 192 HOH HOH A . 
C 3 HOH 162 662 167 HOH HOH A . 
C 3 HOH 163 663 214 HOH HOH A . 
C 3 HOH 164 664 163 HOH HOH A . 
C 3 HOH 165 665 237 HOH HOH A . 
C 3 HOH 166 666 151 HOH HOH A . 
C 3 HOH 167 667 146 HOH HOH A . 
C 3 HOH 168 668 168 HOH HOH A . 
C 3 HOH 169 669 158 HOH HOH A . 
C 3 HOH 170 670 176 HOH HOH A . 
C 3 HOH 171 671 78  HOH HOH A . 
C 3 HOH 172 672 7   HOH HOH A . 
C 3 HOH 173 673 69  HOH HOH A . 
C 3 HOH 174 674 42  HOH HOH A . 
C 3 HOH 175 675 19  HOH HOH A . 
C 3 HOH 176 676 185 HOH HOH A . 
C 3 HOH 177 677 145 HOH HOH A . 
C 3 HOH 178 678 94  HOH HOH A . 
C 3 HOH 179 679 37  HOH HOH A . 
C 3 HOH 180 680 39  HOH HOH A . 
C 3 HOH 181 681 239 HOH HOH A . 
C 3 HOH 182 682 127 HOH HOH A . 
C 3 HOH 183 683 85  HOH HOH A . 
C 3 HOH 184 684 216 HOH HOH A . 
C 3 HOH 185 685 148 HOH HOH A . 
C 3 HOH 186 686 238 HOH HOH A . 
C 3 HOH 187 687 234 HOH HOH A . 
C 3 HOH 188 688 36  HOH HOH A . 
C 3 HOH 189 689 87  HOH HOH A . 
C 3 HOH 190 690 21  HOH HOH A . 
C 3 HOH 191 691 210 HOH HOH A . 
C 3 HOH 192 692 137 HOH HOH A . 
C 3 HOH 193 693 162 HOH HOH A . 
C 3 HOH 194 694 34  HOH HOH A . 
C 3 HOH 195 695 40  HOH HOH A . 
C 3 HOH 196 696 90  HOH HOH A . 
C 3 HOH 197 697 93  HOH HOH A . 
C 3 HOH 198 698 219 HOH HOH A . 
C 3 HOH 199 699 52  HOH HOH A . 
C 3 HOH 200 700 76  HOH HOH A . 
C 3 HOH 201 701 67  HOH HOH A . 
C 3 HOH 202 702 82  HOH HOH A . 
C 3 HOH 203 703 154 HOH HOH A . 
C 3 HOH 204 704 171 HOH HOH A . 
C 3 HOH 205 705 164 HOH HOH A . 
C 3 HOH 206 706 223 HOH HOH A . 
C 3 HOH 207 707 56  HOH HOH A . 
C 3 HOH 208 708 217 HOH HOH A . 
C 3 HOH 209 709 236 HOH HOH A . 
C 3 HOH 210 710 182 HOH HOH A . 
C 3 HOH 211 711 150 HOH HOH A . 
C 3 HOH 212 712 221 HOH HOH A . 
C 3 HOH 213 713 95  HOH HOH A . 
C 3 HOH 214 714 213 HOH HOH A . 
C 3 HOH 215 715 103 HOH HOH A . 
C 3 HOH 216 716 155 HOH HOH A . 
C 3 HOH 217 717 119 HOH HOH A . 
C 3 HOH 218 718 74  HOH HOH A . 
C 3 HOH 219 719 220 HOH HOH A . 
C 3 HOH 220 720 3   HOH HOH A . 
C 3 HOH 221 721 193 HOH HOH A . 
C 3 HOH 222 722 129 HOH HOH A . 
C 3 HOH 223 723 131 HOH HOH A . 
C 3 HOH 224 724 143 HOH HOH A . 
C 3 HOH 225 725 191 HOH HOH A . 
C 3 HOH 226 726 240 HOH HOH A . 
C 3 HOH 227 727 199 HOH HOH A . 
C 3 HOH 228 728 177 HOH HOH A . 
C 3 HOH 229 729 224 HOH HOH A . 
C 3 HOH 230 730 198 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A GLU 47  ? CG  ? A GLU 47  CG  
2  1 Y 1 A GLU 47  ? CD  ? A GLU 47  CD  
3  1 Y 1 A GLU 47  ? OE1 ? A GLU 47  OE1 
4  1 Y 1 A GLU 47  ? OE2 ? A GLU 47  OE2 
5  1 Y 1 A ARG 60  ? CG  ? A ARG 60  CG  
6  1 Y 1 A ARG 60  ? CD  ? A ARG 60  CD  
7  1 Y 1 A ARG 60  ? NE  ? A ARG 60  NE  
8  1 Y 1 A ARG 60  ? CZ  ? A ARG 60  CZ  
9  1 Y 1 A ARG 60  ? NH1 ? A ARG 60  NH1 
10 1 Y 1 A ARG 60  ? NH2 ? A ARG 60  NH2 
11 1 Y 1 A TYR 154 ? CG  ? A TYR 154 CG  
12 1 Y 1 A TYR 154 ? CD1 ? A TYR 154 CD1 
13 1 Y 1 A TYR 154 ? CD2 ? A TYR 154 CD2 
14 1 Y 1 A TYR 154 ? CE1 ? A TYR 154 CE1 
15 1 Y 1 A TYR 154 ? CE2 ? A TYR 154 CE2 
16 1 Y 1 A TYR 154 ? CZ  ? A TYR 154 CZ  
17 1 Y 1 A TYR 154 ? OH  ? A TYR 154 OH  
18 1 Y 1 A ASP 155 ? CG  ? A ASP 155 CG  
19 1 Y 1 A ASP 155 ? OD1 ? A ASP 155 OD1 
20 1 Y 1 A ASP 155 ? OD2 ? A ASP 155 OD2 
21 1 Y 1 A ARG 217 ? CG  ? A ARG 217 CG  
22 1 Y 1 A ARG 217 ? CD  ? A ARG 217 CD  
23 1 Y 1 A ARG 217 ? NE  ? A ARG 217 NE  
24 1 Y 1 A ARG 217 ? CZ  ? A ARG 217 CZ  
25 1 Y 1 A ARG 217 ? NH1 ? A ARG 217 NH1 
26 1 Y 1 A ARG 217 ? NH2 ? A ARG 217 NH2 
27 1 Y 1 A ARG 222 ? CG  ? A ARG 222 CG  
28 1 Y 1 A ARG 222 ? CD  ? A ARG 222 CD  
29 1 Y 1 A ARG 222 ? NE  ? A ARG 222 NE  
30 1 Y 1 A ARG 222 ? CZ  ? A ARG 222 CZ  
31 1 Y 1 A ARG 222 ? NH1 ? A ARG 222 NH1 
32 1 Y 1 A ARG 222 ? NH2 ? A ARG 222 NH2 
33 1 Y 1 A MET 235 ? CG  ? A MET 235 CG  
34 1 Y 1 A MET 235 ? SD  ? A MET 235 SD  
35 1 Y 1 A MET 235 ? CE  ? A MET 235 CE  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   102.833 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BOC 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     113.714 
_cell.length_a_esd                 ? 
_cell.length_b                     53.061 
_cell.length_b_esd                 ? 
_cell.length_c                     45.603 
_cell.length_c_esd                 ? 
_cell.volume                       268285.384 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BOC 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y' 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BOC 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             1.98 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          37.91 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              8.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M BICINE, 15% w/v Polyethylene glycol 1,500' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            294 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-09-15 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97933 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSLS-II BEAMLINE 17-ID-2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97933 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   17-ID-2 
_diffrn_source.pdbx_synchrotron_site       NSLS-II 
# 
_reflns.B_iso_Wilson_estimate                          24.98 
_reflns.entry_id                                       9BOC 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.68 
_reflns.d_resolution_low                               44.46 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     29610 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           97.81 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                4.2 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          11.66 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   1 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.0759 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.68 
_reflns_shell.d_res_low                                     1.74 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.30 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2929 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               3.7 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.502 
_reflns_shell.pdbx_CC_star                                  0.818 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          96.63 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.069 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               31.65 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9BOC 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.68 
_refine.ls_d_res_low                             44.46 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     29576 
_refine.ls_number_reflns_R_free                  1441 
_refine.ls_number_reflns_R_work                  28135 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    97.82 
_refine.ls_percent_reflns_R_free                 4.87 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1906 
_refine.ls_R_factor_R_free                       0.2078 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1896 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 23.5797 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2163 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.68 
_refine_hist.d_res_low                        44.46 
_refine_hist.number_atoms_solvent             230 
_refine_hist.number_atoms_total               2574 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2315 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         29 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0060  ? 2435 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.9169  ? 3322 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0518  ? 379  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0065  ? 432  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 12.3168 ? 864  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.68 1.74  . . 140 2789 96.63 . . . . 0.3040 . . . . . . . . . . . 0.3169 
'X-RAY DIFFRACTION' 1.74 1.81  . . 146 2784 98.82 . . . . 0.2902 . . . . . . . . . . . 0.2997 
'X-RAY DIFFRACTION' 1.81 1.89  . . 170 2850 99.05 . . . . 0.2525 . . . . . . . . . . . 0.3038 
'X-RAY DIFFRACTION' 1.89 1.99  . . 125 2848 99.60 . . . . 0.2376 . . . . . . . . . . . 0.2697 
'X-RAY DIFFRACTION' 1.99 2.12  . . 148 2850 99.60 . . . . 0.2141 . . . . . . . . . . . 0.2490 
'X-RAY DIFFRACTION' 2.12 2.28  . . 117 2457 85.97 . . . . 0.2077 . . . . . . . . . . . 0.1913 
'X-RAY DIFFRACTION' 2.28 2.51  . . 150 2883 99.87 . . . . 0.1948 . . . . . . . . . . . 0.2215 
'X-RAY DIFFRACTION' 2.51 2.88  . . 133 2874 99.70 . . . . 0.2002 . . . . . . . . . . . 0.2259 
'X-RAY DIFFRACTION' 2.88 3.62  . . 159 2869 99.77 . . . . 0.1781 . . . . . . . . . . . 0.2012 
'X-RAY DIFFRACTION' 3.62 44.46 . . 153 2931 99.13 . . . . 0.1502 . . . . . . . . . . . 0.1588 
# 
_struct.entry_id                     9BOC 
_struct.title                        'Crystal Structure of L50F SARS-CoV-2 Main Protease in Complex with GC376' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BOC 
_struct_keywords.text            'Hydrolase, VIRAL PROTEIN' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1AB_SARS2 
_struct_ref.pdbx_db_accession          P0DTD1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_struct_ref.pdbx_align_begin           3264 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9BOC 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 306 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P0DTD1 
_struct_ref_seq.db_align_beg                  3264 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3569 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       306 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             9BOC 
_struct_ref_seq_dif.mon_id                       PHE 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      50 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   P0DTD1 
_struct_ref_seq_dif.db_mon_id                    LEU 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          3313 
_struct_ref_seq_dif.details                      conflict 
_struct_ref_seq_dif.pdbx_auth_seq_num            50 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 3050  ? 
1 MORE         -17   ? 
1 'SSA (A^2)'  24290 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z     1.0000000000  0.0000000000 0.0000000000 0.0000000000   0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000  
2 'crystal symmetry operation' 2_556 -x,y,-z+1 -1.0000000000 0.0000000000 0.0000000000 -10.1288871890 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 44.4639095595 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 10  ? GLY A 15  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 41  ? CYS A 44  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 SER A 46  ? ASN A 51  ? SER A 46  ASN A 51  5 ? 6  
HELX_P HELX_P4  AA4 ASN A 53  ? ARG A 60  ? ASN A 53  ARG A 60  1 ? 8  
HELX_P HELX_P5  AA5 LYS A 61  ? HIS A 64  ? LYS A 61  HIS A 64  5 ? 4  
HELX_P HELX_P6  AA6 ILE A 200 ? ASN A 214 ? ILE A 200 ASN A 214 1 ? 15 
HELX_P HELX_P7  AA7 THR A 226 ? TYR A 237 ? THR A 226 TYR A 237 1 ? 12 
HELX_P HELX_P8  AA8 THR A 243 ? LEU A 250 ? THR A 243 LEU A 250 1 ? 8  
HELX_P HELX_P9  AA9 LEU A 250 ? GLY A 258 ? LEU A 250 GLY A 258 1 ? 9  
HELX_P HELX_P10 AB1 ALA A 260 ? GLY A 275 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P11 AB2 THR A 292 ? GLY A 302 ? THR A 292 GLY A 302 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            covale1 
_struct_conn.conn_type_id                  covale 
_struct_conn.pdbx_leaving_atom_flag        one 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            145 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           B 
_struct_conn.ptnr2_label_comp_id           UED 
_struct_conn.ptnr2_label_seq_id            . 
_struct_conn.ptnr2_label_atom_id           C21 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             145 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            UED 
_struct_conn.ptnr2_auth_seq_id             401 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               1.768 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      UED 
_pdbx_modification_feature.label_asym_id                      B 
_pdbx_modification_feature.label_seq_id                       . 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      145 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       UED 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        401 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       145 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               C21 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                CYS 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        UED 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Covalent chemical modification' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 73  ? LEU A 75  ? VAL A 73  LEU A 75  
AA1 2 PHE A 66  ? ALA A 70  ? PHE A 66  ALA A 70  
AA1 3 MET A 17  ? CYS A 22  ? MET A 17  CYS A 22  
AA1 4 THR A 25  ? LEU A 32  ? THR A 25  LEU A 32  
AA1 5 VAL A 35  ? PRO A 39  ? VAL A 35  PRO A 39  
AA1 6 VAL A 86  ? VAL A 91  ? VAL A 86  VAL A 91  
AA1 7 VAL A 77  ? GLN A 83  ? VAL A 77  GLN A 83  
AA2 1 TYR A 101 ? PHE A 103 ? TYR A 101 PHE A 103 
AA2 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA2 3 VAL A 148 ? ASP A 153 ? VAL A 148 ASP A 153 
AA2 4 THR A 111 ? TYR A 118 ? THR A 111 TYR A 118 
AA2 5 SER A 121 ? ALA A 129 ? SER A 121 ALA A 129 
AA3 1 TYR A 101 ? PHE A 103 ? TYR A 101 PHE A 103 
AA3 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA3 3 HIS A 172 ? THR A 175 ? HIS A 172 THR A 175 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL A 73  ? O VAL A 73  N ALA A 70  ? N ALA A 70  
AA1 2 3 O LEU A 67  ? O LEU A 67  N THR A 21  ? N THR A 21  
AA1 3 4 N VAL A 20  ? N VAL A 20  O LEU A 27  ? O LEU A 27  
AA1 4 5 N LEU A 30  ? N LEU A 30  O TYR A 37  ? O TYR A 37  
AA1 5 6 N VAL A 36  ? N VAL A 36  O LEU A 89  ? O LEU A 89  
AA1 6 7 O VAL A 86  ? O VAL A 86  N GLN A 83  ? N GLN A 83  
AA2 1 2 N LYS A 102 ? N LYS A 102 O PHE A 159 ? O PHE A 159 
AA2 2 3 O SER A 158 ? O SER A 158 N ASN A 151 ? N ASN A 151 
AA2 3 4 O PHE A 150 ? O PHE A 150 N SER A 113 ? N SER A 113 
AA2 4 5 N VAL A 114 ? N VAL A 114 O TYR A 126 ? O TYR A 126 
AA3 1 2 N LYS A 102 ? N LYS A 102 O PHE A 159 ? O PHE A 159 
AA3 2 3 N MET A 165 ? N MET A 165 O ALA A 173 ? O ALA A 173 
# 
_pdbx_entry_details.entry_id                   9BOC 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 33  ? ? 50.80   -136.02 
2 1 ASN A 51  ? ? -156.52 65.32   
3 1 ASN A 84  ? ? 52.97   -121.98 
4 1 TYR A 154 ? ? 58.94   -96.35  
# 
_pdbx_molecule_features.prd_id    PRD_002495 
_pdbx_molecule_features.name      GC376 
_pdbx_molecule_features.type      Peptide-like 
_pdbx_molecule_features.class     Inhibitor 
_pdbx_molecule_features.details   ? 
# 
_pdbx_molecule.instance_id   1 
_pdbx_molecule.prd_id        PRD_002495 
_pdbx_molecule.asym_id       B 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 672 ? C HOH . 
2 1 A HOH 674 ? C HOH . 
3 1 A HOH 720 ? C HOH . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 -x,y,-z         
3 x+1/2,y+1/2,z   
4 -x+1/2,y+1/2,-z 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 729 ? 6.09 . 
2 1 O ? A HOH 730 ? 6.40 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A PHE 305 ? A PHE 305 
2 1 Y 1 A GLN 306 ? A GLN 306 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
UED C7   C N N 372 
UED O8   O N N 373 
UED C9   C N N 374 
UED O10  O N N 375 
UED C1   C Y N 376 
UED C2   C Y N 377 
UED C3   C Y N 378 
UED C4   C Y N 379 
UED C5   C Y N 380 
UED C6   C Y N 381 
UED N11  N N N 382 
UED C12  C N S 383 
UED C17  C N N 384 
UED O18  O N N 385 
UED C13  C N N 386 
UED C14  C N N 387 
UED C15  C N N 388 
UED C16  C N N 389 
UED N19  N N N 390 
UED C20  C N S 391 
UED C21  C N N 392 
UED O22  O N N 393 
UED C24  C N N 394 
UED C25  C N S 395 
UED C26  C N N 396 
UED C27  C N N 397 
UED N28  N N N 398 
UED C29  C N N 399 
UED O30  O N N 400 
UED H1   H N N 401 
UED H2   H N N 402 
UED H3   H N N 403 
UED H4   H N N 404 
UED H5   H N N 405 
UED H6   H N N 406 
UED H7   H N N 407 
UED H8   H N N 408 
UED H9   H N N 409 
UED H10  H N N 410 
UED H11  H N N 411 
UED H12  H N N 412 
UED H13  H N N 413 
UED H14  H N N 414 
UED H15  H N N 415 
UED H16  H N N 416 
UED H17  H N N 417 
UED H18  H N N 418 
UED H19  H N N 419 
UED H20  H N N 420 
UED H21  H N N 421 
UED H22  H N N 422 
UED H23  H N N 423 
UED H24  H N N 424 
UED H25  H N N 425 
UED H26  H N N 426 
UED H27  H N N 427 
UED H28  H N N 428 
UED H29  H N N 429 
UED H30  H N N 430 
UED H31  H N N 431 
VAL N    N N N 432 
VAL CA   C N S 433 
VAL C    C N N 434 
VAL O    O N N 435 
VAL CB   C N N 436 
VAL CG1  C N N 437 
VAL CG2  C N N 438 
VAL OXT  O N N 439 
VAL H    H N N 440 
VAL H2   H N N 441 
VAL HA   H N N 442 
VAL HB   H N N 443 
VAL HG11 H N N 444 
VAL HG12 H N N 445 
VAL HG13 H N N 446 
VAL HG21 H N N 447 
VAL HG22 H N N 448 
VAL HG23 H N N 449 
VAL HXT  H N N 450 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
UED C16 C14  sing N N 358 
UED C3  C2   doub Y N 359 
UED C3  C4   sing Y N 360 
UED C2  C1   sing Y N 361 
UED C14 C13  sing N N 362 
UED C14 C15  sing N N 363 
UED C13 C12  sing N N 364 
UED C4  C5   doub Y N 365 
UED O8  C7   sing N N 366 
UED O8  C9   sing N N 367 
UED N11 C12  sing N N 368 
UED N11 C9   sing N N 369 
UED C1  C7   sing N N 370 
UED C1  C6   doub Y N 371 
UED O18 C17  doub N N 372 
UED C5  C6   sing Y N 373 
UED C12 C17  sing N N 374 
UED C9  O10  doub N N 375 
UED C17 N19  sing N N 376 
UED C26 C27  sing N N 377 
UED C26 C25  sing N N 378 
UED N19 C20  sing N N 379 
UED C20 C21  sing N N 380 
UED C20 C24  sing N N 381 
UED C27 N28  sing N N 382 
UED O22 C21  sing N N 383 
UED C25 C24  sing N N 384 
UED C25 C29  sing N N 385 
UED N28 C29  sing N N 386 
UED C29 O30  doub N N 387 
UED C7  H1   sing N N 388 
UED C7  H2   sing N N 389 
UED C2  H3   sing N N 390 
UED C3  H4   sing N N 391 
UED C4  H5   sing N N 392 
UED C5  H6   sing N N 393 
UED C6  H7   sing N N 394 
UED N11 H8   sing N N 395 
UED C12 H9   sing N N 396 
UED C13 H10  sing N N 397 
UED C13 H11  sing N N 398 
UED C14 H12  sing N N 399 
UED C15 H13  sing N N 400 
UED C15 H14  sing N N 401 
UED C15 H15  sing N N 402 
UED C16 H16  sing N N 403 
UED C16 H17  sing N N 404 
UED C16 H18  sing N N 405 
UED N19 H19  sing N N 406 
UED C20 H20  sing N N 407 
UED C24 H21  sing N N 408 
UED C24 H22  sing N N 409 
UED C25 H23  sing N N 410 
UED C26 H24  sing N N 411 
UED C26 H25  sing N N 412 
UED C27 H26  sing N N 413 
UED C27 H27  sing N N 414 
UED N28 H28  sing N N 415 
UED C21 H29  sing N N 416 
UED C21 H30  sing N N 417 
UED O22 H31  sing N N 418 
VAL N   CA   sing N N 419 
VAL N   H    sing N N 420 
VAL N   H2   sing N N 421 
VAL CA  C    sing N N 422 
VAL CA  CB   sing N N 423 
VAL CA  HA   sing N N 424 
VAL C   O    doub N N 425 
VAL C   OXT  sing N N 426 
VAL CB  CG1  sing N N 427 
VAL CB  CG2  sing N N 428 
VAL CB  HB   sing N N 429 
VAL CG1 HG11 sing N N 430 
VAL CG1 HG12 sing N N 431 
VAL CG1 HG13 sing N N 432 
VAL CG2 HG21 sing N N 433 
VAL CG2 HG22 sing N N 434 
VAL CG2 HG23 sing N N 435 
VAL OXT HXT  sing N N 436 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' 'P30 GM133893' 1 
'Department of Energy (DOE, United States)'                                                'United States' KP1607011      2 
'Other government'                                                                         ?               DE-SC0012704   3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7NF5 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'C 1 2 1' 
_space_group.name_Hall        'C 2y' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9BOC 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.008794 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.002003 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.018846 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.022490 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . SER A 1 1   ? -2.16164  -21.97535 39.21595  1.000 25.52910 ? 1   SER A N    1 
ATOM   2    C CA   . SER A 1 1   ? -2.95791  -20.95111 38.48690  1.000 29.68082 ? 1   SER A CA   1 
ATOM   3    C C    . SER A 1 1   ? -2.60754  -20.91397 37.00076  1.000 29.39002 ? 1   SER A C    1 
ATOM   4    O O    . SER A 1 1   ? -1.86637  -21.75989 36.49708  1.000 27.22125 ? 1   SER A O    1 
ATOM   5    C CB   . SER A 1 1   ? -2.73863  -19.56665 39.10278  1.000 37.79796 ? 1   SER A CB   1 
ATOM   6    O OG   . SER A 1 1   ? -1.43296  -19.08665 38.82975  1.000 36.46102 ? 1   SER A OG   1 
ATOM   7    H H1   . SER A 1 1   ? -1.29449  -21.79632 39.12590  1.000 30.68521 ? 1   SER A H1   1 
ATOM   8    H H2   . SER A 1 1   ? -2.37940  -21.96150 40.07879  1.000 30.68521 ? 1   SER A H2   1 
ATOM   9    H H3   . SER A 1 1   ? -2.33483  -22.78075 38.87915  1.000 30.68521 ? 1   SER A H3   1 
ATOM   10   H HA   . SER A 1 1   ? -3.89710  -21.18087 38.56452  1.000 35.66728 ? 1   SER A HA   1 
ATOM   11   H HB2  . SER A 1 1   ? -3.38569  -18.94924 38.72728  1.000 45.40784 ? 1   SER A HB2  1 
ATOM   12   H HB3  . SER A 1 1   ? -2.85691  -19.62746 40.06362  1.000 45.40784 ? 1   SER A HB3  1 
ATOM   13   H HG   . SER A 1 1   ? -1.34707  -18.30451 39.12381  1.000 43.80351 ? 1   SER A HG   1 
ATOM   14   N N    . GLY A 1 2   ? -3.14856  -19.91494 36.32105  1.000 30.68936 ? 2   GLY A N    1 
ATOM   15   C CA   . GLY A 1 2   ? -3.02775  -19.74148 34.89157  1.000 28.28624 ? 2   GLY A CA   1 
ATOM   16   C C    . GLY A 1 2   ? -4.29458  -20.16448 34.17881  1.000 28.50007 ? 2   GLY A C    1 
ATOM   17   O O    . GLY A 1 2   ? -5.04395  -21.03270 34.63939  1.000 29.27484 ? 2   GLY A O    1 
ATOM   18   H H    . GLY A 1 2   ? -3.61502  -19.29258 36.68804  1.000 36.87753 ? 2   GLY A H    1 
ATOM   19   H HA2  . GLY A 1 2   ? -2.85500  -18.80846 34.69024  1.000 33.99377 ? 2   GLY A HA2  1 
ATOM   20   H HA3  . GLY A 1 2   ? -2.29086  -20.27786 34.55961  1.000 33.99377 ? 2   GLY A HA3  1 
ATOM   21   N N    . PHE A 1 3   ? -4.54077  -19.54703 33.02755  1.000 27.27013 ? 3   PHE A N    1 
ATOM   22   C CA   . PHE A 1 3   ? -5.74287  -19.83348 32.25286  1.000 28.80608 ? 3   PHE A CA   1 
ATOM   23   C C    . PHE A 1 3   ? -5.37182  -19.88641 30.78077  1.000 27.39672 ? 3   PHE A C    1 
ATOM   24   O O    . PHE A 1 3   ? -4.81621  -18.92230 30.24580  1.000 30.27708 ? 3   PHE A O    1 
ATOM   25   C CB   . PHE A 1 3   ? -6.82718  -18.79001 32.49984  1.000 27.37805 ? 3   PHE A CB   1 
ATOM   26   C CG   . PHE A 1 3   ? -8.18725  -19.24179 32.07579  1.000 27.32642 ? 3   PHE A CG   1 
ATOM   27   C CD1  . PHE A 1 3   ? -8.85332  -20.22395 32.79019  1.000 29.65088 ? 3   PHE A CD1  1 
ATOM   28   C CD2  . PHE A 1 3   ? -8.79846  -18.70939 30.95580  1.000 30.85721 ? 3   PHE A CD2  1 
ATOM   29   C CE1  . PHE A 1 3   ? -10.10836 -20.66021 32.40296  1.000 35.33223 ? 3   PHE A CE1  1 
ATOM   30   C CE2  . PHE A 1 3   ? -10.05450 -19.14086 30.56317  1.000 32.69171 ? 3   PHE A CE2  1 
ATOM   31   C CZ   . PHE A 1 3   ? -10.71062 -20.11945 31.28875  1.000 34.93306 ? 3   PHE A CZ   1 
ATOM   32   H H    . PHE A 1 3   ? -4.02506  -18.95674 32.67372  1.000 32.77445 ? 3   PHE A H    1 
ATOM   33   H HA   . PHE A 1 3   ? -6.09317  -20.70027 32.51148  1.000 34.61759 ? 3   PHE A HA   1 
ATOM   34   H HB2  . PHE A 1 3   ? -6.86122  -18.59112 33.44861  1.000 32.90395 ? 3   PHE A HB2  1 
ATOM   35   H HB3  . PHE A 1 3   ? -6.61017  -17.98742 32.00019  1.000 32.90395 ? 3   PHE A HB3  1 
ATOM   36   H HD1  . PHE A 1 3   ? -8.45097  -20.59595 33.54161  1.000 35.63135 ? 3   PHE A HD1  1 
ATOM   37   H HD2  . PHE A 1 3   ? -8.36145  -18.05451 30.46077  1.000 37.07895 ? 3   PHE A HD2  1 
ATOM   38   H HE1  . PHE A 1 3   ? -10.54465 -21.31799 32.89477  1.000 42.44897 ? 3   PHE A HE1  1 
ATOM   39   H HE2  . PHE A 1 3   ? -10.45768 -18.77223 29.81053  1.000 39.28035 ? 3   PHE A HE2  1 
ATOM   40   H HZ   . PHE A 1 3   ? -11.55376 -20.41043 31.02542  1.000 41.96996 ? 3   PHE A HZ   1 
ATOM   41   N N    . ARG A 1 4   ? -5.69927  -21.00043 30.13272  1.000 26.70290 ? 4   ARG A N    1 
ATOM   42   C CA   . ARG A 1 4   ? -5.30598  -21.25957 28.75809  1.000 25.17275 ? 4   ARG A CA   1 
ATOM   43   C C    . ARG A 1 4   ? -6.47301  -21.87351 28.00462  1.000 25.85180 ? 4   ARG A C    1 
ATOM   44   O O    . ARG A 1 4   ? -7.28691  -22.59894 28.57462  1.000 26.47629 ? 4   ARG A O    1 
ATOM   45   C CB   . ARG A 1 4   ? -4.10373  -22.21225 28.69985  1.000 27.33029 ? 4   ARG A CB   1 
ATOM   46   C CG   . ARG A 1 4   ? -2.80121  -21.61787 29.21269  1.000 30.27925 ? 4   ARG A CG   1 
ATOM   47   C CD   . ARG A 1 4   ? -2.29486  -20.49254 28.31066  1.000 31.17677 ? 4   ARG A CD   1 
ATOM   48   N NE   . ARG A 1 4   ? -2.30338  -20.88064 26.90507  1.000 27.22967 ? 4   ARG A NE   1 
ATOM   49   C CZ   . ARG A 1 4   ? -1.39036  -21.65625 26.33795  1.000 29.73007 ? 4   ARG A CZ   1 
ATOM   50   N NH1  . ARG A 1 4   ? -0.35361  -22.11703 27.01872  1.000 26.05776 ? 4   ARG A NH1  1 
ATOM   51   N NH2  . ARG A 1 4   ? -1.52781  -21.98633 25.05562  1.000 46.74552 ? 4   ARG A NH2  1 
ATOM   52   H H    . ARG A 1 4   ? -6.16164  -21.63692 30.48014  1.000 32.09377 ? 4   ARG A H    1 
ATOM   53   H HA   . ARG A 1 4   ? -5.06960  -20.42472 28.32444  1.000 30.25759 ? 4   ARG A HA   1 
ATOM   54   H HB2  . ARG A 1 4   ? -4.30204  -22.99300 29.24021  1.000 32.84664 ? 4   ARG A HB2  1 
ATOM   55   H HB3  . ARG A 1 4   ? -3.96232  -22.47482 27.77683  1.000 32.84664 ? 4   ARG A HB3  1 
ATOM   56   H HG2  . ARG A 1 4   ? -2.94327  -21.25418 30.10063  1.000 36.38539 ? 4   ARG A HG2  1 
ATOM   57   H HG3  . ARG A 1 4   ? -2.12321  -22.31093 29.24260  1.000 36.38539 ? 4   ARG A HG3  1 
ATOM   58   H HD2  . ARG A 1 4   ? -2.86734  -19.71649 28.41514  1.000 37.46241 ? 4   ARG A HD2  1 
ATOM   59   H HD3  . ARG A 1 4   ? -1.38418  -20.26880 28.55866  1.000 37.46241 ? 4   ARG A HD3  1 
ATOM   60   H HE   . ARG A 1 4   ? -2.94327  -20.58679 26.41131  1.000 32.72590 ? 4   ARG A HE   1 
ATOM   61   H HH11 . ARG A 1 4   ? -0.26030  -21.91462 27.84934  1.000 31.31960 ? 4   ARG A HH11 1 
ATOM   62   H HH12 . ARG A 1 4   ? 0.22695   -22.61893 26.63059  1.000 31.31960 ? 4   ARG A HH12 1 
ATOM   63   H HH21 . ARG A 1 4   ? -2.20205  -21.69696 24.60700  1.000 56.14492 ? 4   ARG A HH21 1 
ATOM   64   H HH22 . ARG A 1 4   ? -0.94236  -22.48893 24.67584  1.000 56.14492 ? 4   ARG A HH22 1 
ATOM   65   N N    . LYS A 1 5   ? -6.55367  -21.57394 26.70972  1.000 25.12628 ? 5   LYS A N    1 
ATOM   66   C CA   . LYS A 1 5   ? -7.45553  -22.31090 25.83506  1.000 25.20881 ? 5   LYS A CA   1 
ATOM   67   C C    . LYS A 1 5   ? -6.96367  -23.75008 25.75391  1.000 24.40719 ? 5   LYS A C    1 
ATOM   68   O O    . LYS A 1 5   ? -5.83638  -24.00856 25.31426  1.000 24.63960 ? 5   LYS A O    1 
ATOM   69   C CB   . LYS A 1 5   ? -7.50807  -21.66825 24.46072  1.000 28.65106 ? 5   LYS A CB   1 
ATOM   70   C CG   . LYS A 1 5   ? -8.90162  -21.60341 23.87142  1.000 32.79127 ? 5   LYS A CG   1 
ATOM   71   C CD   . LYS A 1 5   ? -8.86077  -21.00617 22.48755  1.000 36.00850 ? 5   LYS A CD   1 
ATOM   72   C CE   . LYS A 1 5   ? -8.87712  -19.50262 22.54567  1.000 35.23758 ? 5   LYS A CE   1 
ATOM   73   N NZ   . LYS A 1 5   ? -10.26057 -19.01034 22.76747  1.000 38.51798 ? 5   LYS A NZ   1 
ATOM   74   H H    . LYS A 1 5   ? -6.10123  -20.95524 26.31971  1.000 30.20182 ? 5   LYS A H    1 
ATOM   75   H HA   . LYS A 1 5   ? -8.35879  -22.29865 26.18845  1.000 30.30086 ? 5   LYS A HA   1 
ATOM   76   H HB2  . LYS A 1 5   ? -7.17215  -20.76074 24.52767  1.000 34.43157 ? 5   LYS A HB2  1 
ATOM   77   H HB3  . LYS A 1 5   ? -6.95350  -22.18337 23.85408  1.000 34.43157 ? 5   LYS A HB3  1 
ATOM   78   H HG2  . LYS A 1 5   ? -9.27143  -22.49813 23.81138  1.000 39.39981 ? 5   LYS A HG2  1 
ATOM   79   H HG3  . LYS A 1 5   ? -9.46618  -21.04797 24.43148  1.000 39.39981 ? 5   LYS A HG3  1 
ATOM   80   H HD2  . LYS A 1 5   ? -8.04792  -21.28675 22.03872  1.000 43.26048 ? 5   LYS A HD2  1 
ATOM   81   H HD3  . LYS A 1 5   ? -9.63610  -21.30195 21.98528  1.000 43.26048 ? 5   LYS A HD3  1 
ATOM   82   H HE2  . LYS A 1 5   ? -8.31879  -19.19897 23.27845  1.000 42.33538 ? 5   LYS A HE2  1 
ATOM   83   H HE3  . LYS A 1 5   ? -8.54996  -19.14074 21.70728  1.000 42.33538 ? 5   LYS A HE3  1 
ATOM   84   H HZ1  . LYS A 1 5   ? -10.26390 -18.12146 22.81198  1.000 46.27187 ? 5   LYS A HZ1  1 
ATOM   85   H HZ2  . LYS A 1 5   ? -10.78645 -19.26794 22.09725  1.000 46.27187 ? 5   LYS A HZ2  1 
ATOM   86   H HZ3  . LYS A 1 5   ? -10.58207 -19.33890 23.52956  1.000 46.27187 ? 5   LYS A HZ3  1 
ATOM   87   N N    . MET A 1 6   ? -7.80774  -24.68189 26.18872  1.000 23.35743 ? 6   MET A N    1 
ATOM   88   C CA   . MET A 1 6   ? -7.40493  -26.05414 26.46531  1.000 25.07571 ? 6   MET A CA   1 
ATOM   89   C C    . MET A 1 6   ? -8.34812  -27.00413 25.75710  1.000 25.39190 ? 6   MET A C    1 
ATOM   90   O O    . MET A 1 6   ? -9.56392  -26.94783 25.96619  1.000 27.24243 ? 6   MET A O    1 
ATOM   91   C CB   . MET A 1 6   ? -7.44055  -26.29363 27.96819  1.000 28.14087 ? 6   MET A CB   1 
ATOM   92   C CG   . MET A 1 6   ? -6.64874  -27.43953 28.46263  1.000 30.54398 ? 6   MET A CG   1 
ATOM   93   S SD   . MET A 1 6   ? -6.59210  -27.27040 30.25413  1.000 35.05710 ? 6   MET A SD   1 
ATOM   94   C CE   . MET A 1 6   ? -6.10840  -28.91866 30.72325  1.000 35.22673 ? 6   MET A CE   1 
ATOM   95   H H    . MET A 1 6   ? -8.64281  -24.53722 26.33474  1.000 28.07920 ? 6   MET A H    1 
ATOM   96   H HA   . MET A 1 6   ? -6.50839  -26.21124 26.12998  1.000 30.14115 ? 6   MET A HA   1 
ATOM   97   H HB2  . MET A 1 6   ? -7.10081  -25.49941 28.40942  1.000 33.81934 ? 6   MET A HB2  1 
ATOM   98   H HB3  . MET A 1 6   ? -8.36203  -26.44909 28.22820  1.000 33.81934 ? 6   MET A HB3  1 
ATOM   99   H HG2  . MET A 1 6   ? -7.07638  -28.27739 28.22596  1.000 36.70307 ? 6   MET A HG2  1 
ATOM   100  H HG3  . MET A 1 6   ? -5.74850  -27.41317 28.10239  1.000 36.70307 ? 6   MET A HG3  1 
ATOM   101  H HE1  . MET A 1 6   ? -5.82467  -28.91257 31.65081  1.000 42.32236 ? 6   MET A HE1  1 
ATOM   102  H HE2  . MET A 1 6   ? -5.37664  -29.20671 30.15540  1.000 42.32236 ? 6   MET A HE2  1 
ATOM   103  H HE3  . MET A 1 6   ? -6.86653  -29.51365 30.61315  1.000 42.32236 ? 6   MET A HE3  1 
ATOM   104  N N    . ALA A 1 7   ? -7.79678  -27.88487 24.94805  1.000 23.32818 ? 7   ALA A N    1 
ATOM   105  C CA   . ALA A 1 7   ? -8.62789  -28.88228 24.30568  1.000 23.35943 ? 7   ALA A CA   1 
ATOM   106  C C    . ALA A 1 7   ? -8.68486  -30.14321 25.14315  1.000 24.02557 ? 7   ALA A C    1 
ATOM   107  O O    . ALA A 1 7   ? -7.82093  -30.39961 25.98478  1.000 23.38924 ? 7   ALA A O    1 
ATOM   108  C CB   . ALA A 1 7   ? -8.08707  -29.21891 22.92704  1.000 24.25758 ? 7   ALA A CB   1 
ATOM   109  H H    . ALA A 1 7   ? -6.95909  -27.92566 24.75777  1.000 28.04411 ? 7   ALA A H    1 
ATOM   110  H HA   . ALA A 1 7   ? -9.52701  -28.53151 24.20842  1.000 28.08160 ? 7   ALA A HA   1 
ATOM   111  H HB1  . ALA A 1 7   ? -8.24044  -28.46591 22.33512  1.000 29.15938 ? 7   ALA A HB1  1 
ATOM   112  H HB2  . ALA A 1 7   ? -7.13610  -29.39730 22.99576  1.000 29.15938 ? 7   ALA A HB2  1 
ATOM   113  H HB3  . ALA A 1 7   ? -8.54730  -30.00353 22.59020  1.000 29.15938 ? 7   ALA A HB3  1 
ATOM   114  N N    . PHE A 1 8   ? -9.71148  -30.94550 24.89337  1.000 23.87754 ? 8   PHE A N    1 
ATOM   115  C CA   . PHE A 1 8   ? -9.76442  -32.25146 25.50794  1.000 25.45112 ? 8   PHE A CA   1 
ATOM   116  C C    . PHE A 1 8   ? -8.66169  -33.14002 24.94645  1.000 22.75156 ? 8   PHE A C    1 
ATOM   117  O O    . PHE A 1 8   ? -8.25025  -32.98618 23.79181  1.000 23.34272 ? 8   PHE A O    1 
ATOM   118  C CB   . PHE A 1 8   ? -11.10115 -32.93347 25.25326  1.000 25.82047 ? 8   PHE A CB   1 
ATOM   119  C CG   . PHE A 1 8   ? -12.25398 -32.25351 25.90521  1.000 25.49179 ? 8   PHE A CG   1 
ATOM   120  C CD1  . PHE A 1 8   ? -12.55439 -32.47096 27.23904  1.000 31.74665 ? 8   PHE A CD1  1 
ATOM   121  C CD2  . PHE A 1 8   ? -13.05411 -31.39546 25.17787  1.000 27.99361 ? 8   PHE A CD2  1 
ATOM   122  C CE1  . PHE A 1 8   ? -13.63736 -31.83203 27.83114  1.000 33.09023 ? 8   PHE A CE1  1 
ATOM   123  C CE2  . PHE A 1 8   ? -14.12626 -30.75988 25.76295  1.000 31.54780 ? 8   PHE A CE2  1 
ATOM   124  C CZ   . PHE A 1 8   ? -14.42034 -30.97620 27.08933  1.000 32.66797 ? 8   PHE A CZ   1 
ATOM   125  H H    . PHE A 1 8   ? -10.37538 -30.75624 24.38051  1.000 28.70334 ? 8   PHE A H    1 
ATOM   126  H HA   . PHE A 1 8   ? -9.64885  -32.14581 26.46522  1.000 30.59163 ? 8   PHE A HA   1 
ATOM   127  H HB2  . PHE A 1 8   ? -11.26726 -32.94752 24.29769  1.000 31.03486 ? 8   PHE A HB2  1 
ATOM   128  H HB3  . PHE A 1 8   ? -11.05933 -33.83990 25.59609  1.000 31.03486 ? 8   PHE A HB3  1 
ATOM   129  H HD1  . PHE A 1 8   ? -12.02765 -33.04883 27.74255  1.000 38.14627 ? 8   PHE A HD1  1 
ATOM   130  H HD2  . PHE A 1 8   ? -12.86628 -31.24449 24.27964  1.000 33.64263 ? 8   PHE A HD2  1 
ATOM   131  H HE1  . PHE A 1 8   ? -13.83303 -31.98246 28.72779  1.000 39.75856 ? 8   PHE A HE1  1 
ATOM   132  H HE2  . PHE A 1 8   ? -14.65352 -30.18229 25.25968  1.000 37.90765 ? 8   PHE A HE2  1 
ATOM   133  H HZ   . PHE A 1 8   ? -15.14483 -30.54625 27.48322  1.000 39.25185 ? 8   PHE A HZ   1 
ATOM   134  N N    . PRO A 1 9   ? -8.19523  -34.10240 25.73106  1.000 25.14645 ? 9   PRO A N    1 
ATOM   135  C CA   . PRO A 1 9   ? -7.28935  -35.11242 25.17706  1.000 24.67597 ? 9   PRO A CA   1 
ATOM   136  C C    . PRO A 1 9   ? -8.00052  -35.85813 24.06247  1.000 24.91609 ? 9   PRO A C    1 
ATOM   137  O O    . PRO A 1 9   ? -9.16159  -36.26053 24.19259  1.000 26.24694 ? 9   PRO A O    1 
ATOM   138  C CB   . PRO A 1 9   ? -6.97407  -36.00871 26.37639  1.000 25.34521 ? 9   PRO A CB   1 
ATOM   139  C CG   . PRO A 1 9   ? -7.40370  -35.19983 27.59765  1.000 29.87726 ? 9   PRO A CG   1 
ATOM   140  C CD   . PRO A 1 9   ? -8.59518  -34.43245 27.10647  1.000 24.30715 ? 9   PRO A CD   1 
ATOM   141  H HA   . PRO A 1 9   ? -6.45906  -34.72784 24.85517  1.000 29.66146 ? 9   PRO A HA   1 
ATOM   142  H HB2  . PRO A 1 9   ? -7.47799  -36.83508 26.31251  1.000 30.46454 ? 9   PRO A HB2  1 
ATOM   143  H HB3  . PRO A 1 9   ? -6.02372  -36.20095 26.40411  1.000 30.46454 ? 9   PRO A HB3  1 
ATOM   144  H HG2  . PRO A 1 9   ? -7.64281  -35.79266 28.32723  1.000 35.90300 ? 9   PRO A HG2  1 
ATOM   145  H HG3  . PRO A 1 9   ? -6.69047  -34.60365 27.87475  1.000 35.90300 ? 9   PRO A HG3  1 
ATOM   146  H HD2  . PRO A 1 9   ? -9.39473  -34.98154 27.11704  1.000 29.21887 ? 9   PRO A HD2  1 
ATOM   147  H HD3  . PRO A 1 9   ? -8.73682  -33.62999 27.63268  1.000 29.21887 ? 9   PRO A HD3  1 
ATOM   148  N N    . SER A 1 10  ? -7.28404  -36.03844 22.96037  1.000 23.96295 ? 10  SER A N    1 
ATOM   149  C CA   . SER A 1 10  ? -7.85169  -36.47415 21.69976  1.000 23.92094 ? 10  SER A CA   1 
ATOM   150  C C    . SER A 1 10  ? -7.78376  -37.98055 21.48354  1.000 25.78148 ? 10  SER A C    1 
ATOM   151  O O    . SER A 1 10  ? -8.31461  -38.46326 20.48086  1.000 24.61632 ? 10  SER A O    1 
ATOM   152  C CB   . SER A 1 10  ? -7.12334  -35.75391 20.55227  1.000 24.28365 ? 10  SER A CB   1 
ATOM   153  O OG   . SER A 1 10  ? -5.72028  -35.97484 20.59146  1.000 25.40009 ? 10  SER A OG   1 
ATOM   154  H H    . SER A 1 10  ? -6.43481  -35.90906 22.91945  1.000 28.80583 ? 10  SER A H    1 
ATOM   155  H HA   . SER A 1 10  ? -8.79095  -36.23274 21.67958  1.000 28.75542 ? 10  SER A HA   1 
ATOM   156  H HB2  . SER A 1 10  ? -7.46725  -36.08610 19.70830  1.000 29.19068 ? 10  SER A HB2  1 
ATOM   157  H HB3  . SER A 1 10  ? -7.29060  -34.80135 20.62681  1.000 29.19068 ? 10  SER A HB3  1 
ATOM   158  H HG   . SER A 1 10  ? -5.49606  -36.50685 19.98130  1.000 30.53040 ? 10  SER A HG   1 
ATOM   159  N N    . GLY A 1 11  ? -7.18390  -38.73279 22.40491  1.000 25.95508 ? 11  GLY A N    1 
ATOM   160  C CA   . GLY A 1 11  ? -6.88587  -40.13033 22.12699  1.000 25.96843 ? 11  GLY A CA   1 
ATOM   161  C C    . GLY A 1 11  ? -8.09170  -40.94377 21.69900  1.000 25.61654 ? 11  GLY A C    1 
ATOM   162  O O    . GLY A 1 11  ? -8.00449  -41.77144 20.78827  1.000 25.38340 ? 11  GLY A O    1 
ATOM   163  H H    . GLY A 1 11  ? -6.94383  -38.46155 23.18490  1.000 31.19639 ? 11  GLY A H    1 
ATOM   164  H HA2  . GLY A 1 11  ? -6.22674  -40.17648 21.41684  1.000 31.21240 ? 11  GLY A HA2  1 
ATOM   165  H HA3  . GLY A 1 11  ? -6.51808  -40.53877 22.92625  1.000 31.21240 ? 11  GLY A HA3  1 
ATOM   166  N N    . LYS A 1 12  ? -9.23141  -40.73443 22.35587  1.000 24.92184 ? 12  LYS A N    1 
ATOM   167  C CA   . LYS A 1 12  ? -10.40047 -41.55275 22.04780  1.000 24.66481 ? 12  LYS A CA   1 
ATOM   168  C C    . LYS A 1 12  ? -10.91625 -41.28855 20.64190  1.000 26.35531 ? 12  LYS A C    1 
ATOM   169  O O    . LYS A 1 12  ? -11.49200 -42.18637 20.01820  1.000 26.27521 ? 12  LYS A O    1 
ATOM   170  C CB   . LYS A 1 12  ? -11.49901 -41.29908 23.07487  1.000 29.42128 ? 12  LYS A CB   1 
ATOM   171  C CG   . LYS A 1 12  ? -11.23517 -41.96289 24.41112  1.000 33.95003 ? 12  LYS A CG   1 
ATOM   172  C CD   . LYS A 1 12  ? -12.16453 -41.43629 25.47682  1.000 44.30766 ? 12  LYS A CD   1 
ATOM   173  C CE   . LYS A 1 12  ? -12.14265 -42.32578 26.71351  1.000 53.84908 ? 12  LYS A CE   1 
ATOM   174  N NZ   . LYS A 1 12  ? -12.88211 -41.71692 27.85479  1.000 53.88051 ? 12  LYS A NZ   1 
ATOM   175  H H    . LYS A 1 12  ? -9.35093  -40.14161 22.96733  1.000 29.95650 ? 12  LYS A H    1 
ATOM   176  H HA   . LYS A 1 12  ? -10.15046 -42.48846 22.10122  1.000 29.64806 ? 12  LYS A HA   1 
ATOM   177  H HB2  . LYS A 1 12  ? -11.57244 -40.34374 23.22597  1.000 35.35582 ? 12  LYS A HB2  1 
ATOM   178  H HB3  . LYS A 1 12  ? -12.33675 -41.64579 22.73006  1.000 35.35582 ? 12  LYS A HB3  1 
ATOM   179  H HG2  . LYS A 1 12  ? -11.37479 -42.91926 24.32893  1.000 40.79033 ? 12  LYS A HG2  1 
ATOM   180  H HG3  . LYS A 1 12  ? -10.32228 -41.78325 24.68545  1.000 40.79033 ? 12  LYS A HG3  1 
ATOM   181  H HD2  . LYS A 1 12  ? -11.88557 -40.54419 25.73612  1.000 53.21948 ? 12  LYS A HD2  1 
ATOM   182  H HD3  . LYS A 1 12  ? -13.07087 -41.41336 25.13194  1.000 53.21948 ? 12  LYS A HD3  1 
ATOM   183  H HE2  . LYS A 1 12  ? -12.55915 -43.17594 26.50222  1.000 64.66919 ? 12  LYS A HE2  1 
ATOM   184  H HE3  . LYS A 1 12  ? -11.22328 -42.46615 26.98910  1.000 64.66919 ? 12  LYS A HE3  1 
ATOM   185  H HZ1  . LYS A 1 12  ? -13.72917 -41.56964 27.62479  1.000 64.70690 ? 12  LYS A HZ1  1 
ATOM   186  H HZ2  . LYS A 1 12  ? -12.86428 -42.26474 28.55599  1.000 64.70690 ? 12  LYS A HZ2  1 
ATOM   187  H HZ3  . LYS A 1 12  ? -12.50610 -40.94323 28.08307  1.000 64.70690 ? 12  LYS A HZ3  1 
ATOM   188  N N    . VAL A 1 13  ? -10.73133 -40.06406 20.13879  1.000 24.31611 ? 13  VAL A N    1 
ATOM   189  C CA   . VAL A 1 13  ? -11.17544 -39.71432 18.79315  1.000 23.77615 ? 13  VAL A CA   1 
ATOM   190  C C    . VAL A 1 13  ? -10.13879 -40.09587 17.74685  1.000 22.77719 ? 13  VAL A C    1 
ATOM   191  O O    . VAL A 1 13  ? -10.49706 -40.43587 16.60968  1.000 22.24429 ? 13  VAL A O    1 
ATOM   192  C CB   . VAL A 1 13  ? -11.48578 -38.20888 18.72864  1.000 21.59890 ? 13  VAL A CB   1 
ATOM   193  C CG1  . VAL A 1 13  ? -11.89381 -37.79533 17.31775  1.000 23.68989 ? 13  VAL A CG1  1 
ATOM   194  C CG2  . VAL A 1 13  ? -12.54955 -37.84157 19.75616  1.000 22.98052 ? 13  VAL A CG2  1 
ATOM   195  H H    . VAL A 1 13  ? -10.35022 -39.41760 20.55884  1.000 29.22963 ? 13  VAL A H    1 
ATOM   196  H HA   . VAL A 1 13  ? -11.98416 -40.21342 18.59882  1.000 28.58167 ? 13  VAL A HA   1 
ATOM   197  H HB   . VAL A 1 13  ? -10.68294 -37.71061 18.94788  1.000 25.96897 ? 13  VAL A HB   1 
ATOM   198  H HG11 . VAL A 1 13  ? -12.60307 -37.13606 17.37459  1.000 28.47816 ? 13  VAL A HG11 1 
ATOM   199  H HG12 . VAL A 1 13  ? -11.12459 -37.41543 16.86512  1.000 28.47816 ? 13  VAL A HG12 1 
ATOM   200  H HG13 . VAL A 1 13  ? -12.20713 -38.57769 16.83751  1.000 28.47816 ? 13  VAL A HG13 1 
ATOM   201  H HG21 . VAL A 1 13  ? -13.19684 -38.56186 19.81190  1.000 27.62691 ? 13  VAL A HG21 1 
ATOM   202  H HG22 . VAL A 1 13  ? -12.12435 -37.71152 20.61825  1.000 27.62691 ? 13  VAL A HG22 1 
ATOM   203  H HG23 . VAL A 1 13  ? -12.98881 -37.02297 19.47715  1.000 27.62691 ? 13  VAL A HG23 1 
ATOM   204  N N    . GLU A 1 14  ? -8.85100  -40.00196 18.08531  1.000 22.05525 ? 14  GLU A N    1 
ATOM   205  C CA   . GLU A 1 14  ? -7.80567  -40.41390 17.15150  1.000 22.94604 ? 14  GLU A CA   1 
ATOM   206  C C    . GLU A 1 14  ? -8.08906  -41.79916 16.61220  1.000 23.10781 ? 14  GLU A C    1 
ATOM   207  O O    . GLU A 1 14  ? -7.91011  -42.06456 15.41856  1.000 23.71754 ? 14  GLU A O    1 
ATOM   208  C CB   . GLU A 1 14  ? -6.44493  -40.38963 17.84237  1.000 23.97991 ? 14  GLU A CB   1 
ATOM   209  C CG   . GLU A 1 14  ? -5.96136  -38.99268 18.13070  1.000 23.10270 ? 14  GLU A CG   1 
ATOM   210  C CD   . GLU A 1 14  ? -4.69178  -38.96755 18.94045  1.000 24.14685 ? 14  GLU A CD   1 
ATOM   211  O OE1  . GLU A 1 14  ? -3.74093  -39.69129 18.59987  1.000 27.02298 ? 14  GLU A OE1  1 
ATOM   212  O OE2  . GLU A 1 14  ? -4.65448  -38.21283 19.93096  1.000 24.90477 ? 14  GLU A OE2  1 
ATOM   213  H H    . GLU A 1 14  ? -8.56076  -39.70707 18.83923  1.000 26.51659 ? 14  GLU A H    1 
ATOM   214  H HA   . GLU A 1 14  ? -7.77797  -39.78841 16.41062  1.000 27.58554 ? 14  GLU A HA   1 
ATOM   215  H HB2  . GLU A 1 14  ? -6.51075  -40.86452 18.68561  1.000 28.82619 ? 14  GLU A HB2  1 
ATOM   216  H HB3  . GLU A 1 14  ? -5.79222  -40.82083 17.26885  1.000 28.82619 ? 14  GLU A HB3  1 
ATOM   217  H HG2  . GLU A 1 14  ? -5.78984  -38.53850 17.29093  1.000 27.77353 ? 14  GLU A HG2  1 
ATOM   218  H HG3  . GLU A 1 14  ? -6.64460  -38.51910 18.63049  1.000 27.77353 ? 14  GLU A HG3  1 
ATOM   219  N N    . GLY A 1 15  ? -8.53511  -42.70337 17.48591  1.000 24.03246 ? 15  GLY A N    1 
ATOM   220  C CA   . GLY A 1 15  ? -8.77384  -44.07789 17.09286  1.000 23.52676 ? 15  GLY A CA   1 
ATOM   221  C C    . GLY A 1 15  ? -9.97831  -44.25947 16.19616  1.000 24.17815 ? 15  GLY A C    1 
ATOM   222  O O    . GLY A 1 15  ? -10.21154 -45.38282 15.72726  1.000 25.72995 ? 15  GLY A O    1 
ATOM   223  H H    . GLY A 1 15  ? -8.70559  -42.53900 18.31266  1.000 28.88925 ? 15  GLY A H    1 
ATOM   224  H HA2  . GLY A 1 15  ? -7.99492  -44.40919 16.61912  1.000 28.28240 ? 15  GLY A HA2  1 
ATOM   225  H HA3  . GLY A 1 15  ? -8.91020  -44.61361 17.88993  1.000 28.28240 ? 15  GLY A HA3  1 
ATOM   226  N N    . CYS A 1 16  ? -10.73276 -43.20106 15.95458  1.000 21.97692 ? 16  CYS A N    1 
ATOM   227  C CA   . CYS A 1 16  ? -11.89770 -43.26452 15.08885  1.000 22.57080 ? 16  CYS A CA   1 
ATOM   228  C C    . CYS A 1 16  ? -11.67205 -42.63693 13.71533  1.000 20.89174 ? 16  CYS A C    1 
ATOM   229  O O    . CYS A 1 16  ? -12.57638 -42.68591 12.87898  1.000 21.29403 ? 16  CYS A O    1 
ATOM   230  C CB   . CYS A 1 16  ? -13.07953 -42.56248 15.76817  1.000 21.19020 ? 16  CYS A CB   1 
ATOM   231  S SG   . CYS A 1 16  ? -13.54282 -43.20654 17.39599  1.000 25.97783 ? 16  CYS A SG   1 
ATOM   232  H H    . CYS A 1 16  ? -10.58853 -42.42069 16.28596  1.000 26.42260 ? 16  CYS A H    1 
ATOM   233  H HA   . CYS A 1 16  ? -12.12806 -44.19620 14.94809  1.000 27.13526 ? 16  CYS A HA   1 
ATOM   234  H HB2  . CYS A 1 16  ? -12.85265 -41.62635 15.88253  1.000 25.47853 ? 16  CYS A HB2  1 
ATOM   235  H HB3  . CYS A 1 16  ? -13.85584 -42.64781 15.19286  1.000 25.47853 ? 16  CYS A HB3  1 
ATOM   236  H HG   . CYS A 1 16  ? -13.82981 -44.36688 17.28983  1.000 31.22368 ? 16  CYS A HG   1 
ATOM   237  N N    . MET A 1 17  ? -10.51845 -42.02835 13.46371  1.000 20.52470 ? 17  MET A N    1 
ATOM   238  C CA   . MET A 1 17  ? -10.31514 -41.30848 12.20965  1.000 20.74293 ? 17  MET A CA   1 
ATOM   239  C C    . MET A 1 17  ? -9.83093  -42.25806 11.12238  1.000 21.51375 ? 17  MET A C    1 
ATOM   240  O O    . MET A 1 17  ? -8.87903  -43.02183 11.32982  1.000 21.31015 ? 17  MET A O    1 
ATOM   241  C CB   . MET A 1 17  ? -9.32231  -40.16261 12.40602  1.000 23.64952 ? 17  MET A CB   1 
ATOM   242  C CG   . MET A 1 17  ? -9.77701  -39.11961 13.42671  1.000 21.50478 ? 17  MET A CG   1 
ATOM   243  S SD   . MET A 1 17  ? -11.49992 -38.56572 13.27037  1.000 21.20774 ? 17  MET A SD   1 
ATOM   244  C CE   . MET A 1 17  ? -11.57008 -38.09410 11.54440  1.000 23.06553 ? 17  MET A CE   1 
ATOM   245  H H    . MET A 1 17  ? -9.84432  -42.01755 13.99759  1.000 24.67993 ? 17  MET A H    1 
ATOM   246  H HA   . MET A 1 17  ? -11.16104 -40.92763 11.92626  1.000 24.94181 ? 17  MET A HA   1 
ATOM   247  H HB2  . MET A 1 17  ? -8.47927  -40.53026 12.71424  1.000 28.42972 ? 17  MET A HB2  1 
ATOM   248  H HB3  . MET A 1 17  ? -9.19650  -39.71052 11.55708  1.000 28.42972 ? 17  MET A HB3  1 
ATOM   249  H HG2  . MET A 1 17  ? -9.67576  -39.49733 14.31439  1.000 25.85602 ? 17  MET A HG2  1 
ATOM   250  H HG3  . MET A 1 17  ? -9.21332  -38.33575 13.33343  1.000 25.85602 ? 17  MET A HG3  1 
ATOM   251  H HE1  . MET A 1 17  ? -12.45372 -37.74558 11.34793  1.000 27.72892 ? 17  MET A HE1  1 
ATOM   252  H HE2  . MET A 1 17  ? -10.90070 -37.41264 11.37578  1.000 27.72892 ? 17  MET A HE2  1 
ATOM   253  H HE3  . MET A 1 17  ? -11.39293 -38.87456 10.99631  1.000 27.72892 ? 17  MET A HE3  1 
ATOM   254  N N    . VAL A 1 18  ? -10.49477 -42.20871 9.96240   1.000 21.01303 ? 18  VAL A N    1 
ATOM   255  C CA   . VAL A 1 18  ? -10.10906 -42.97269 8.78411   1.000 22.02188 ? 18  VAL A CA   1 
ATOM   256  C C    . VAL A 1 18  ? -10.03386 -42.03443 7.58083   1.000 21.21326 ? 18  VAL A C    1 
ATOM   257  O O    . VAL A 1 18  ? -10.45979 -40.88077 7.62812   1.000 20.73029 ? 18  VAL A O    1 
ATOM   258  C CB   . VAL A 1 18  ? -11.08775 -44.13137 8.49573   1.000 20.97617 ? 18  VAL A CB   1 
ATOM   259  C CG1  . VAL A 1 18  ? -11.10046 -45.11011 9.64758   1.000 22.63439 ? 18  VAL A CG1  1 
ATOM   260  C CG2  . VAL A 1 18  ? -12.48018 -43.57539 8.22350   1.000 20.35502 ? 18  VAL A CG2  1 
ATOM   261  H H    . VAL A 1 18  ? -11.19295 -41.72287 9.83552   1.000 25.26593 ? 18  VAL A H    1 
ATOM   262  H HA   . VAL A 1 18  ? -9.22434  -43.34235 8.93081   1.000 26.47655 ? 18  VAL A HA   1 
ATOM   263  H HB   . VAL A 1 18  ? -10.79735 -44.61513 7.70671   1.000 25.22170 ? 18  VAL A HB   1 
ATOM   264  H HG11 . VAL A 1 18  ? -11.79977 -45.76536 9.49751   1.000 27.21155 ? 18  VAL A HG11 1 
ATOM   265  H HG12 . VAL A 1 18  ? -10.23822 -45.55179 9.69622   1.000 27.21155 ? 18  VAL A HG12 1 
ATOM   266  H HG13 . VAL A 1 18  ? -11.27135 -44.62662 10.47094  1.000 27.21155 ? 18  VAL A HG13 1 
ATOM   267  H HG21 . VAL A 1 18  ? -13.10509 -43.96612 8.85415   1.000 24.47631 ? 18  VAL A HG21 1 
ATOM   268  H HG22 . VAL A 1 18  ? -12.46176 -42.61145 8.33022   1.000 24.47631 ? 18  VAL A HG22 1 
ATOM   269  H HG23 . VAL A 1 18  ? -12.73939 -43.80292 7.31690   1.000 24.47631 ? 18  VAL A HG23 1 
ATOM   270  N N    . GLN A 1 19  ? -9.46654  -42.55697 6.49697   1.000 22.65663 ? 19  GLN A N    1 
ATOM   271  C CA   . GLN A 1 19  ? -9.39326  -41.87203 5.21324   1.000 22.39036 ? 19  GLN A CA   1 
ATOM   272  C C    . GLN A 1 19  ? -10.50321 -42.40593 4.31519   1.000 22.08033 ? 19  GLN A C    1 
ATOM   273  O O    . GLN A 1 19  ? -10.72045 -43.61962 4.25539   1.000 23.04926 ? 19  GLN A O    1 
ATOM   274  C CB   . GLN A 1 19  ? -8.02980  -42.09611 4.57241   1.000 23.64720 ? 19  GLN A CB   1 
ATOM   275  C CG   . GLN A 1 19  ? -7.89001  -41.53516 3.19324   1.000 28.27850 ? 19  GLN A CG   1 
ATOM   276  C CD   . GLN A 1 19  ? -6.53117  -41.81173 2.62468   1.000 31.58393 ? 19  GLN A CD   1 
ATOM   277  O OE1  . GLN A 1 19  ? -5.63367  -40.97556 2.70318   1.000 35.70313 ? 19  GLN A OE1  1 
ATOM   278  N NE2  . GLN A 1 19  ? -6.35728  -43.00094 2.06291   1.000 38.77114 ? 19  GLN A NE2  1 
ATOM   279  H H    . GLN A 1 19  ? -9.10389  -43.33662 6.48147   1.000 27.23825 ? 19  GLN A H    1 
ATOM   280  H HA   . GLN A 1 19  ? -9.51905  -40.91698 5.32710   1.000 26.91873 ? 19  GLN A HA   1 
ATOM   281  H HB2  . GLN A 1 19  ? -7.35486  -41.67656 5.12859   1.000 28.42693 ? 19  GLN A HB2  1 
ATOM   282  H HB3  . GLN A 1 19  ? -7.86791  -43.05093 4.51760   1.000 28.42693 ? 19  GLN A HB3  1 
ATOM   283  H HG2  . GLN A 1 19  ? -8.55255  -41.94122 2.61268   1.000 33.98449 ? 19  GLN A HG2  1 
ATOM   284  H HG3  . GLN A 1 19  ? -8.01907  -40.57424 3.22274   1.000 33.98449 ? 19  GLN A HG3  1 
ATOM   285  H HE21 . GLN A 1 19  ? -7.00642  -43.56457 2.03964   1.000 46.57566 ? 19  GLN A HE21 1 
ATOM   286  H HE22 . GLN A 1 19  ? -5.59542  -43.20820 1.72201   1.000 46.57566 ? 19  GLN A HE22 1 
ATOM   287  N N    . VAL A 1 20  ? -11.21287 -41.50595 3.64115   1.000 21.18885 ? 20  VAL A N    1 
ATOM   288  C CA   . VAL A 1 20  ? -12.23928 -41.88467 2.67638   1.000 21.97394 ? 20  VAL A CA   1 
ATOM   289  C C    . VAL A 1 20  ? -11.89007 -41.22806 1.35090   1.000 23.25659 ? 20  VAL A C    1 
ATOM   290  O O    . VAL A 1 20  ? -11.79230 -39.99529 1.27474   1.000 23.02066 ? 20  VAL A O    1 
ATOM   291  C CB   . VAL A 1 20  ? -13.64832 -41.46842 3.12474   1.000 21.09101 ? 20  VAL A CB   1 
ATOM   292  C CG1  . VAL A 1 20  ? -14.65205 -41.88394 2.06085   1.000 23.41562 ? 20  VAL A CG1  1 
ATOM   293  C CG2  . VAL A 1 20  ? -13.99004 -42.08102 4.45919   1.000 22.04997 ? 20  VAL A CG2  1 
ATOM   294  H H    . VAL A 1 20  ? -11.11558 -40.65586 3.72769   1.000 25.47691 ? 20  VAL A H    1 
ATOM   295  H HA   . VAL A 1 20  ? -12.22798 -42.84847 2.56753   1.000 26.41902 ? 20  VAL A HA   1 
ATOM   296  H HB   . VAL A 1 20  ? -13.68547 -40.50534 3.23435   1.000 25.35950 ? 20  VAL A HB   1 
ATOM   297  H HG11 . VAL A 1 20  ? -14.85508 -41.11770 1.50178   1.000 28.14903 ? 20  VAL A HG11 1 
ATOM   298  H HG12 . VAL A 1 20  ? -14.26663 -42.59310 1.52285   1.000 28.14903 ? 20  VAL A HG12 1 
ATOM   299  H HG13 . VAL A 1 20  ? -15.45985 -42.19992 2.49503   1.000 28.14903 ? 20  VAL A HG13 1 
ATOM   300  H HG21 . VAL A 1 20  ? -13.34639 -41.77943 5.11923   1.000 26.51025 ? 20  VAL A HG21 1 
ATOM   301  H HG22 . VAL A 1 20  ? -14.88270 -41.80132 4.71577   1.000 26.51025 ? 20  VAL A HG22 1 
ATOM   302  H HG23 . VAL A 1 20  ? -13.95578 -43.04726 4.38116   1.000 26.51025 ? 20  VAL A HG23 1 
ATOM   303  N N    . THR A 1 21  ? -11.68886 -42.03789 0.32121   1.000 23.69008 ? 21  THR A N    1 
ATOM   304  C CA   . THR A 1 21  ? -11.42500 -41.55251 -1.02431  1.000 24.63877 ? 21  THR A CA   1 
ATOM   305  C C    . THR A 1 21  ? -12.53002 -42.02792 -1.95016  1.000 25.47729 ? 21  THR A C    1 
ATOM   306  O O    . THR A 1 21  ? -12.94749 -43.18576 -1.90036  1.000 25.95274 ? 21  THR A O    1 
ATOM   307  C CB   . THR A 1 21  ? -10.07268 -42.04617 -1.53981  1.000 28.17499 ? 21  THR A CB   1 
ATOM   308  O OG1  . THR A 1 21  ? -9.04185  -41.62978 -0.63554  1.000 25.99976 ? 21  THR A OG1  1 
ATOM   309  C CG2  . THR A 1 21  ? -9.77755  -41.49032 -2.91682  1.000 32.15074 ? 21  THR A CG2  1 
ATOM   310  H H    . THR A 1 21  ? -11.70073 -42.89585 0.37918   1.000 28.47838 ? 21  THR A H    1 
ATOM   311  H HA   . THR A 1 21  ? -11.41077 -40.58261 -1.02436  1.000 29.61682 ? 21  THR A HA   1 
ATOM   312  H HB   . THR A 1 21  ? -10.08899 -43.01394 -1.60349  1.000 33.86028 ? 21  THR A HB   1 
ATOM   313  H HG1  . THR A 1 21  ? -9.14196  -42.00772 0.10792   1.000 31.25001 ? 21  THR A HG1  1 
ATOM   314  H HG21 . THR A 1 21  ? -10.13555 -40.59227 -2.99580  1.000 38.63118 ? 21  THR A HG21 1 
ATOM   315  H HG22 . THR A 1 21  ? -8.81929  -41.46133 -3.06450  1.000 38.63118 ? 21  THR A HG22 1 
ATOM   316  H HG23 . THR A 1 21  ? -10.18378 -42.05196 -3.59537  1.000 38.63118 ? 21  THR A HG23 1 
ATOM   317  N N    . CYS A 1 22  ? -13.00217 -41.11531 -2.79327  1.000 24.61943 ? 22  CYS A N    1 
ATOM   318  C CA   . CYS A 1 22  ? -13.99083 -41.42872 -3.82112  1.000 26.55466 ? 22  CYS A CA   1 
ATOM   319  C C    . CYS A 1 22  ? -13.46588 -40.73858 -5.07177  1.000 30.99060 ? 22  CYS A C    1 
ATOM   320  O O    . CYS A 1 22  ? -13.42788 -39.50648 -5.14020  1.000 32.69127 ? 22  CYS A O    1 
ATOM   321  C CB   . CYS A 1 22  ? -15.37767 -40.94361 -3.42426  1.000 28.03895 ? 22  CYS A CB   1 
ATOM   322  S SG   . CYS A 1 22  ? -16.71362 -41.50482 -4.49006  1.000 31.84054 ? 22  CYS A SG   1 
ATOM   323  H H    . CYS A 1 22  ? -12.76051 -40.28997 -2.79030  1.000 29.59360 ? 22  CYS A H    1 
ATOM   324  H HA   . CYS A 1 22  ? -14.07335 -42.38248 -3.97739  1.000 31.91588 ? 22  CYS A HA   1 
ATOM   325  H HB2  . CYS A 1 22  ? -15.56849 -41.26023 -2.52746  1.000 33.69702 ? 22  CYS A HB2  1 
ATOM   326  H HB3  . CYS A 1 22  ? -15.37997 -39.97376 -3.44118  1.000 33.69702 ? 22  CYS A HB3  1 
ATOM   327  H HG   . CYS A 1 22  ? -16.81206 -42.69724 -4.39815  1.000 38.25894 ? 22  CYS A HG   1 
ATOM   328  N N    . GLY A 1 23  ? -12.98616 -41.53161 -6.02549  1.000 32.49350 ? 23  GLY A N    1 
ATOM   329  C CA   . GLY A 1 23  ? -12.33459 -40.98556 -7.18133  1.000 34.18261 ? 23  GLY A CA   1 
ATOM   330  C C    . GLY A 1 23  ? -11.05271 -40.27555 -6.79970  1.000 34.29994 ? 23  GLY A C    1 
ATOM   331  O O    . GLY A 1 23  ? -10.14600 -40.86587 -6.20243  1.000 36.12714 ? 23  GLY A O    1 
ATOM   332  H H    . GLY A 1 23  ? -13.03154 -42.39035 -6.01556  1.000 39.04249 ? 23  GLY A H    1 
ATOM   333  H HA2  . GLY A 1 23  ? -12.12210 -41.69904 -7.80317  1.000 41.06942 ? 23  GLY A HA2  1 
ATOM   334  H HA3  . GLY A 1 23  ? -12.92385 -40.35091 -7.61824  1.000 41.06942 ? 23  GLY A HA3  1 
ATOM   335  N N    . THR A 1 24  ? -10.98628 -38.99749 -7.12542  1.000 36.11931 ? 24  THR A N    1 
ATOM   336  C CA   . THR A 1 24  ? -9.80819  -38.19093 -6.85769  1.000 39.56850 ? 24  THR A CA   1 
ATOM   337  C C    . THR A 1 24  ? -9.88420  -37.47570 -5.51814  1.000 38.32737 ? 24  THR A C    1 
ATOM   338  O O    . THR A 1 24  ? -8.86072  -36.98677 -5.02936  1.000 38.26065 ? 24  THR A O    1 
ATOM   339  C CB   . THR A 1 24  ? -9.62824  -37.16828 -7.98238  1.000 47.48420 ? 24  THR A CB   1 
ATOM   340  O OG1  . THR A 1 24  ? -8.34144  -36.54921 -7.87530  1.000 47.79014 ? 24  THR A OG1  1 
ATOM   341  C CG2  . THR A 1 24  ? -10.73141 -36.10426 -7.91444  1.000 49.73888 ? 24  THR A CG2  1 
ATOM   342  H H    . THR A 1 24  ? -11.62216 -38.56465 -7.51001  1.000 43.39347 ? 24  THR A H    1 
ATOM   343  H HA   . THR A 1 24  ? -9.02161  -38.75832 -6.84135  1.000 47.53249 ? 24  THR A HA   1 
ATOM   344  H HB   . THR A 1 24  ? -9.68914  -37.61290 -8.84232  1.000 57.03133 ? 24  THR A HB   1 
ATOM   345  H HG1  . THR A 1 24  ? -7.74042  -37.09795 -8.08327  1.000 57.39845 ? 24  THR A HG1  1 
ATOM   346  H HG21 . THR A 1 24  ? -10.57093 -35.50725 -7.16696  1.000 59.73695 ? 24  THR A HG21 1 
ATOM   347  H HG22 . THR A 1 24  ? -10.74343 -35.58601 -8.73430  1.000 59.73695 ? 24  THR A HG22 1 
ATOM   348  H HG23 . THR A 1 24  ? -11.59554 -36.52926 -7.79797  1.000 59.73695 ? 24  THR A HG23 1 
ATOM   349  N N    . THR A 1 25  ? -11.06306 -37.41841 -4.91352  1.000 32.50806 ? 25  THR A N    1 
ATOM   350  C CA   . THR A 1 25  ? -11.29346 -36.63165 -3.71330  1.000 32.00387 ? 25  THR A CA   1 
ATOM   351  C C    . THR A 1 25  ? -11.03590 -37.48485 -2.48179  1.000 29.12347 ? 25  THR A C    1 
ATOM   352  O O    . THR A 1 25  ? -11.64781 -38.54536 -2.32031  1.000 28.70709 ? 25  THR A O    1 
ATOM   353  C CB   . THR A 1 25  ? -12.73067 -36.11080 -3.70648  1.000 29.47291 ? 25  THR A CB   1 
ATOM   354  O OG1  . THR A 1 25  ? -13.00479 -35.46003 -4.95350  1.000 34.01193 ? 25  THR A OG1  1 
ATOM   355  C CG2  . THR A 1 25  ? -12.95326 -35.14607 -2.55818  1.000 34.53900 ? 25  THR A CG2  1 
ATOM   356  H H    . THR A 1 25  ? -11.76234 -37.83761 -5.18715  1.000 39.05996 ? 25  THR A H    1 
ATOM   357  H HA   . THR A 1 25  ? -10.67926 -35.88115 -3.69296  1.000 38.45493 ? 25  THR A HA   1 
ATOM   358  H HB   . THR A 1 25  ? -13.34484 -36.85226 -3.58850  1.000 35.41778 ? 25  THR A HB   1 
ATOM   359  H HG1  . THR A 1 25  ? -12.42583 -34.87008 -5.10305  1.000 40.86461 ? 25  THR A HG1  1 
ATOM   360  H HG21 . THR A 1 25  ? -13.84665 -34.77152 -2.60797  1.000 41.49709 ? 25  THR A HG21 1 
ATOM   361  H HG22 . THR A 1 25  ? -12.85273 -35.60899 -1.71172  1.000 41.49709 ? 25  THR A HG22 1 
ATOM   362  H HG23 . THR A 1 25  ? -12.30653 -34.42440 -2.60106  1.000 41.49709 ? 25  THR A HG23 1 
ATOM   363  N N    . THR A 1 26  ? -10.13615 -37.02606 -1.61655  1.000 29.08693 ? 26  THR A N    1 
ATOM   364  C CA   . THR A 1 26  ? -9.87058  -37.68223 -0.34604  1.000 26.68866 ? 26  THR A CA   1 
ATOM   365  C C    . THR A 1 26  ? -10.20724 -36.73001 0.79593   1.000 24.91022 ? 26  THR A C    1 
ATOM   366  O O    . THR A 1 26  ? -9.89642  -35.53692 0.73900   1.000 25.29822 ? 26  THR A O    1 
ATOM   367  C CB   . THR A 1 26  ? -8.40700  -38.13725 -0.24787  1.000 27.28573 ? 26  THR A CB   1 
ATOM   368  O OG1  . THR A 1 26  ? -8.15208  -39.18409 -1.19294  1.000 31.60399 ? 26  THR A OG1  1 
ATOM   369  C CG2  . THR A 1 26  ? -8.11580  -38.65057 1.14503   1.000 28.28979 ? 26  THR A CG2  1 
ATOM   370  H H    . THR A 1 26  ? -9.65938  -36.32258 -1.74844  1.000 34.95461 ? 26  THR A H    1 
ATOM   371  H HA   . THR A 1 26  ? -10.43118 -38.46915 -0.26014  1.000 32.07668 ? 26  THR A HA   1 
ATOM   372  H HB   . THR A 1 26  ? -7.82371  -37.38608 -0.43867  1.000 32.79316 ? 26  THR A HB   1 
ATOM   373  H HG1  . THR A 1 26  ? -8.65675  -39.83802 -1.04040  1.000 37.97508 ? 26  THR A HG1  1 
ATOM   374  H HG21 . THR A 1 26  ? -8.04220  -37.90727 1.76389   1.000 33.99804 ? 26  THR A HG21 1 
ATOM   375  H HG22 . THR A 1 26  ? -8.83138  -39.23557 1.43935   1.000 33.99804 ? 26  THR A HG22 1 
ATOM   376  H HG23 . THR A 1 26  ? -7.28223  -39.14661 1.14827   1.000 33.99804 ? 26  THR A HG23 1 
ATOM   377  N N    . LEU A 1 27  ? -10.88165 -37.26073 1.81349   1.000 23.22256 ? 27  LEU A N    1 
ATOM   378  C CA   . LEU A 1 27  ? -11.08549 -36.53111 3.05812   1.000 21.52484 ? 27  LEU A CA   1 
ATOM   379  C C    . LEU A 1 27  ? -11.16406 -37.53981 4.20147   1.000 20.57640 ? 27  LEU A C    1 
ATOM   380  O O    . LEU A 1 27  ? -10.81257 -38.71232 4.04861   1.000 21.52266 ? 27  LEU A O    1 
ATOM   381  C CB   . LEU A 1 27  ? -12.31775 -35.62339 2.94129   1.000 20.92245 ? 27  LEU A CB   1 
ATOM   382  C CG   . LEU A 1 27  ? -13.58427 -36.23932 2.35884   1.000 21.49264 ? 27  LEU A CG   1 
ATOM   383  C CD1  . LEU A 1 27  ? -14.14333 -37.29422 3.29043   1.000 21.93420 ? 27  LEU A CD1  1 
ATOM   384  C CD2  . LEU A 1 27  ? -14.60456 -35.15134 2.08742   1.000 21.96250 ? 27  LEU A CD2  1 
ATOM   385  H H    . LEU A 1 27  ? -11.23194 -38.04612 1.80537   1.000 27.91736 ? 27  LEU A H    1 
ATOM   386  H HA   . LEU A 1 27  ? -10.31811 -35.96421 3.23326   1.000 25.88010 ? 27  LEU A HA   1 
ATOM   387  H HB2  . LEU A 1 27  ? -12.54087 -35.30846 3.83120   1.000 25.15723 ? 27  LEU A HB2  1 
ATOM   388  H HB3  . LEU A 1 27  ? -12.08205 -34.87324 2.37329   1.000 25.15723 ? 27  LEU A HB3  1 
ATOM   389  H HG   . LEU A 1 27  ? -13.37720 -36.67792 1.51881   1.000 25.84146 ? 27  LEU A HG   1 
ATOM   390  H HD11 . LEU A 1 27  ? -15.04905 -37.50871 3.01736   1.000 26.37133 ? 27  LEU A HD11 1 
ATOM   391  H HD12 . LEU A 1 27  ? -13.58634 -38.08679 3.24056   1.000 26.37133 ? 27  LEU A HD12 1 
ATOM   392  H HD13 . LEU A 1 27  ? -14.14437 -36.94711 4.19620   1.000 26.37133 ? 27  LEU A HD13 1 
ATOM   393  H HD21 . LEU A 1 27  ? -14.43981 -34.40713 2.68734   1.000 26.40530 ? 27  LEU A HD21 1 
ATOM   394  H HD22 . LEU A 1 27  ? -14.51751 -34.85939 1.16651   1.000 26.40530 ? 27  LEU A HD22 1 
ATOM   395  H HD23 . LEU A 1 27  ? -15.49398 -35.50761 2.23881   1.000 26.40530 ? 27  LEU A HD23 1 
ATOM   396  N N    . ASN A 1 28  ? -11.59251 -37.06785 5.36390   1.000 20.24364 ? 28  ASN A N    1 
ATOM   397  C CA   . ASN A 1 28  ? -11.55218 -37.86854 6.57631   1.000 19.22797 ? 28  ASN A CA   1 
ATOM   398  C C    . ASN A 1 28  ? -12.93149 -38.42259 6.87826   1.000 21.00468 ? 28  ASN A C    1 
ATOM   399  O O    . ASN A 1 28  ? -13.95034 -37.80117 6.56657   1.000 20.31104 ? 28  ASN A O    1 
ATOM   400  C CB   . ASN A 1 28  ? -11.09280 -37.04024 7.77710   1.000 20.73814 ? 28  ASN A CB   1 
ATOM   401  C CG   . ASN A 1 28  ? -9.77242  -36.35925 7.54249   1.000 20.81593 ? 28  ASN A CG   1 
ATOM   402  O OD1  . ASN A 1 28  ? -8.71707  -36.98491 7.61537   1.000 21.67818 ? 28  ASN A OD1  1 
ATOM   403  N ND2  . ASN A 1 28  ? -9.81827  -35.05861 7.28666   1.000 20.63308 ? 28  ASN A ND2  1 
ATOM   404  H H    . ASN A 1 28  ? -11.91419 -36.27816 5.47572   1.000 24.34266 ? 28  ASN A H    1 
ATOM   405  H HA   . ASN A 1 28  ? -10.92801 -38.59942 6.44541   1.000 23.12385 ? 28  ASN A HA   1 
ATOM   406  H HB2  . ASN A 1 28  ? -11.75497 -36.35567 7.96093   1.000 24.93606 ? 28  ASN A HB2  1 
ATOM   407  H HB3  . ASN A 1 28  ? -10.99691 -37.62400 8.54582   1.000 24.93606 ? 28  ASN A HB3  1 
ATOM   408  H HD21 . ASN A 1 28  ? -9.09081  -34.62229 7.14522   1.000 24.80998 ? 28  ASN A HD21 1 
ATOM   409  H HD22 . ASN A 1 28  ? -10.57548 -34.65162 7.26223   1.000 24.80998 ? 28  ASN A HD22 1 
ATOM   410  N N    . GLY A 1 29  ? -12.95335 -39.58198 7.53352   1.000 20.29284 ? 29  GLY A N    1 
ATOM   411  C CA   . GLY A 1 29  ? -14.18653 -40.16322 8.00558   1.000 20.13078 ? 29  GLY A CA   1 
ATOM   412  C C    . GLY A 1 29  ? -14.08681 -40.50504 9.47905   1.000 19.95415 ? 29  GLY A C    1 
ATOM   413  O O    . GLY A 1 29  ? -12.99916 -40.62674 10.04001  1.000 19.75861 ? 29  GLY A O    1 
ATOM   414  H H    . GLY A 1 29  ? -12.25470 -40.04959 7.71471   1.000 24.40170 ? 29  GLY A H    1 
ATOM   415  H HA2  . GLY A 1 29  ? -14.91491 -39.53530 7.87887   1.000 24.20722 ? 29  GLY A HA2  1 
ATOM   416  H HA3  . GLY A 1 29  ? -14.37847 -40.97396 7.50882   1.000 24.20722 ? 29  GLY A HA3  1 
ATOM   417  N N    . LEU A 1 30  ? -15.25377 -40.65199 10.10324  1.000 19.09804 ? 30  LEU A N    1 
ATOM   418  C CA   . LEU A 1 30  ? -15.34811 -41.02514 11.51317  1.000 19.51249 ? 30  LEU A CA   1 
ATOM   419  C C    . LEU A 1 30  ? -15.91790 -42.43808 11.61375  1.000 20.16649 ? 30  LEU A C    1 
ATOM   420  O O    . LEU A 1 30  ? -17.07024 -42.67533 11.23551  1.000 19.97729 ? 30  LEU A O    1 
ATOM   421  C CB   . LEU A 1 30  ? -16.20726 -40.03114 12.29466  1.000 19.45687 ? 30  LEU A CB   1 
ATOM   422  C CG   . LEU A 1 30  ? -16.31986 -40.28136 13.79968  1.000 19.66990 ? 30  LEU A CG   1 
ATOM   423  C CD1  . LEU A 1 30  ? -15.04299 -39.92582 14.52966  1.000 20.27038 ? 30  LEU A CD1  1 
ATOM   424  C CD2  . LEU A 1 30  ? -17.45602 -39.50222 14.40982  1.000 18.98269 ? 30  LEU A CD2  1 
ATOM   425  H H    . LEU A 1 30  ? -16.01739 -40.53887 9.72417   1.000 22.96794 ? 30  LEU A H    1 
ATOM   426  H HA   . LEU A 1 30  ? -14.46108 -41.02602 11.90571  1.000 23.46528 ? 30  LEU A HA   1 
ATOM   427  H HB2  . LEU A 1 30  ? -15.82759 -39.14616 12.17816  1.000 23.39854 ? 30  LEU A HB2  1 
ATOM   428  H HB3  . LEU A 1 30  ? -17.10616 -40.05700 11.93106  1.000 23.39854 ? 30  LEU A HB3  1 
ATOM   429  H HG   . LEU A 1 30  ? -16.48960 -41.23003 13.90975  1.000 23.65417 ? 30  LEU A HG   1 
ATOM   430  H HD11 . LEU A 1 30  ? -14.29157 -40.32615 14.06491  1.000 24.37474 ? 30  LEU A HD11 1 
ATOM   431  H HD12 . LEU A 1 30  ? -14.94629 -38.96077 14.54510  1.000 24.37474 ? 30  LEU A HD12 1 
ATOM   432  H HD13 . LEU A 1 30  ? -15.09166 -40.26791 15.43603  1.000 24.37474 ? 30  LEU A HD13 1 
ATOM   433  H HD21 . LEU A 1 30  ? -17.41271 -39.58448 15.37536  1.000 22.82952 ? 30  LEU A HD21 1 
ATOM   434  H HD22 . LEU A 1 30  ? -17.37362 -38.57041 14.15321  1.000 22.82952 ? 30  LEU A HD22 1 
ATOM   435  H HD23 . LEU A 1 30  ? -18.29612 -39.86185 14.08456  1.000 22.82952 ? 30  LEU A HD23 1 
ATOM   436  N N    . TRP A 1 31  ? -15.11190 -43.36878 12.12786  1.000 19.93832 ? 31  TRP A N    1 
ATOM   437  C CA   . TRP A 1 31  ? -15.45272 -44.78648 12.18215  1.000 21.88035 ? 31  TRP A CA   1 
ATOM   438  C C    . TRP A 1 31  ? -15.93762 -45.15044 13.58403  1.000 22.68420 ? 31  TRP A C    1 
ATOM   439  O O    . TRP A 1 31  ? -15.15780 -45.15236 14.53991  1.000 22.33643 ? 31  TRP A O    1 
ATOM   440  C CB   . TRP A 1 31  ? -14.23029 -45.61431 11.77988  1.000 21.92351 ? 31  TRP A CB   1 
ATOM   441  C CG   . TRP A 1 31  ? -14.40873 -47.11110 11.70603  1.000 22.92037 ? 31  TRP A CG   1 
ATOM   442  C CD1  . TRP A 1 31  ? -15.57608 -47.81802 11.57964  1.000 23.76839 ? 31  TRP A CD1  1 
ATOM   443  C CD2  . TRP A 1 31  ? -13.35810 -48.08208 11.74000  1.000 24.53175 ? 31  TRP A CD2  1 
ATOM   444  N NE1  . TRP A 1 31  ? -15.30754 -49.17128 11.54075  1.000 23.83467 ? 31  TRP A NE1  1 
ATOM   445  C CE2  . TRP A 1 31  ? -13.95291 -49.35706 11.63493  1.000 24.56625 ? 31  TRP A CE2  1 
ATOM   446  C CE3  . TRP A 1 31  ? -11.96698 -47.99575 11.85908  1.000 25.48717 ? 31  TRP A CE3  1 
ATOM   447  C CZ2  . TRP A 1 31  ? -13.20425 -50.53362 11.64910  1.000 26.05213 ? 31  TRP A CZ2  1 
ATOM   448  C CZ3  . TRP A 1 31  ? -11.22725 -49.16433 11.86476  1.000 26.70303 ? 31  TRP A CZ3  1 
ATOM   449  C CH2  . TRP A 1 31  ? -11.84516 -50.41516 11.76031  1.000 28.47741 ? 31  TRP A CH2  1 
ATOM   450  H H    . TRP A 1 31  ? -14.33839 -43.19515 12.46122  1.000 23.97627 ? 31  TRP A H    1 
ATOM   451  H HA   . TRP A 1 31  ? -16.18654 -44.97035 11.57502  1.000 26.30671 ? 31  TRP A HA   1 
ATOM   452  H HB2  . TRP A 1 31  ? -13.94663 -45.32064 10.90000  1.000 26.35850 ? 31  TRP A HB2  1 
ATOM   453  H HB3  . TRP A 1 31  ? -13.52859 -45.44588 12.42806  1.000 26.35850 ? 31  TRP A HB3  1 
ATOM   454  H HD1  . TRP A 1 31  ? -16.42469 -47.44112 11.52770  1.000 28.57236 ? 31  TRP A HD1  1 
ATOM   455  H HE1  . TRP A 1 31  ? -15.89435 -49.79588 11.46911  1.000 28.65189 ? 31  TRP A HE1  1 
ATOM   456  H HE3  . TRP A 1 31  ? -11.54782 -47.16887 11.93297  1.000 30.63490 ? 31  TRP A HE3  1 
ATOM   457  H HZ2  . TRP A 1 31  ? -13.61274 -51.36668 11.58543  1.000 31.31285 ? 31  TRP A HZ2  1 
ATOM   458  H HZ3  . TRP A 1 31  ? -10.30143 -49.11774 11.93943  1.000 32.09392 ? 31  TRP A HZ3  1 
ATOM   459  H HH2  . TRP A 1 31  ? -11.32083 -51.18324 11.76659  1.000 34.22318 ? 31  TRP A HH2  1 
ATOM   460  N N    . LEU A 1 32  ? -17.22964 -45.44390 13.70393  1.000 22.39088 ? 32  LEU A N    1 
ATOM   461  C CA   . LEU A 1 32  ? -17.84224 -45.79935 14.97886  1.000 21.83418 ? 32  LEU A CA   1 
ATOM   462  C C    . LEU A 1 32  ? -18.71466 -47.02319 14.75352  1.000 23.45250 ? 32  LEU A C    1 
ATOM   463  O O    . LEU A 1 32  ? -19.56861 -47.00933 13.85953  1.000 24.26202 ? 32  LEU A O    1 
ATOM   464  C CB   . LEU A 1 32  ? -18.69255 -44.65821 15.53766  1.000 23.42546 ? 32  LEU A CB   1 
ATOM   465  C CG   . LEU A 1 32  ? -18.00615 -43.33099 15.83719  1.000 22.33028 ? 32  LEU A CG   1 
ATOM   466  C CD1  . LEU A 1 32  ? -19.06207 -42.26683 16.04092  1.000 22.70283 ? 32  LEU A CD1  1 
ATOM   467  C CD2  . LEU A 1 32  ? -17.13411 -43.46277 17.05583  1.000 21.77605 ? 32  LEU A CD2  1 
ATOM   468  H H    . LEU A 1 32  ? -17.78324 -45.44365 13.04581  1.000 26.91935 ? 32  LEU A H    1 
ATOM   469  H HA   . LEU A 1 32  ? -17.15125 -46.00319 15.62839  1.000 26.25130 ? 32  LEU A HA   1 
ATOM   470  H HB2  . LEU A 1 32  ? -19.39232 -44.46997 14.89285  1.000 28.16085 ? 32  LEU A HB2  1 
ATOM   471  H HB3  . LEU A 1 32  ? -19.08309 -44.96358 16.37141  1.000 28.16085 ? 32  LEU A HB3  1 
ATOM   472  H HG   . LEU A 1 32  ? -17.43719 -43.06897 15.09655  1.000 26.84663 ? 32  LEU A HG   1 
ATOM   473  H HD11 . LEU A 1 32  ? -19.70441 -42.58073 16.69649  1.000 27.29369 ? 32  LEU A HD11 1 
ATOM   474  H HD12 . LEU A 1 32  ? -18.63558 -41.45535 16.35792  1.000 27.29369 ? 32  LEU A HD12 1 
ATOM   475  H HD13 . LEU A 1 32  ? -19.50747 -42.09803 15.19592  1.000 27.29369 ? 32  LEU A HD13 1 
ATOM   476  H HD21 . LEU A 1 32  ? -16.40796 -42.82251 16.99527  1.000 26.18155 ? 32  LEU A HD21 1 
ATOM   477  H HD22 . LEU A 1 32  ? -17.66718 -43.28454 17.84638  1.000 26.18155 ? 32  LEU A HD22 1 
ATOM   478  H HD23 . LEU A 1 32  ? -16.77799 -44.36425 17.09335  1.000 26.18155 ? 32  LEU A HD23 1 
ATOM   479  N N    . ASP A 1 33  ? -18.51999 -48.06952 15.57421  1.000 26.63648 ? 33  ASP A N    1 
ATOM   480  C CA   . ASP A 1 33  ? -19.14310 -49.35810 15.31285  1.000 26.44144 ? 33  ASP A CA   1 
ATOM   481  C C    . ASP A 1 33  ? -18.82199 -49.71396 13.85056  1.000 24.67309 ? 33  ASP A C    1 
ATOM   482  O O    . ASP A 1 33  ? -17.67160 -49.53569 13.43278  1.000 23.64456 ? 33  ASP A O    1 
ATOM   483  C CB   . ASP A 1 33  ? -20.63277 -49.30210 15.67780  1.000 26.28465 ? 33  ASP A CB   1 
ATOM   484  C CG   . ASP A 1 33  ? -20.84631 -48.86441 17.13952  1.000 29.25326 ? 33  ASP A CG   1 
ATOM   485  O OD1  . ASP A 1 33  ? -20.11132 -49.34523 18.02970  1.000 32.91395 ? 33  ASP A OD1  1 
ATOM   486  O OD2  . ASP A 1 33  ? -21.74189 -48.03044 17.39363  1.000 32.47903 ? 33  ASP A OD2  1 
ATOM   487  H H    . ASP A 1 33  ? -18.03259 -48.04932 16.28247  1.000 32.01406 ? 33  ASP A H    1 
ATOM   488  H HA   . ASP A 1 33  ? -18.80703 -50.08317 15.86260  1.000 31.78002 ? 33  ASP A HA   1 
ATOM   489  H HB2  . ASP A 1 33  ? -21.07983 -48.66345 15.10061  1.000 31.59187 ? 33  ASP A HB2  1 
ATOM   490  H HB3  . ASP A 1 33  ? -21.02347 -50.18258 15.56372  1.000 31.59187 ? 33  ASP A HB3  1 
ATOM   491  N N    . ASP A 1 34  ? -19.77663 -50.20702 13.06022  1.000 24.13537 ? 34  ASP A N    1 
ATOM   492  C CA   . ASP A 1 34  ? -19.48604 -50.61083 11.68575  1.000 24.70211 ? 34  ASP A CA   1 
ATOM   493  C C    . ASP A 1 34  ? -19.90511 -49.54935 10.67122  1.000 23.82985 ? 34  ASP A C    1 
ATOM   494  O O    . ASP A 1 34  ? -20.31056 -49.87846 9.54915   1.000 24.48733 ? 34  ASP A O    1 
ATOM   495  C CB   . ASP A 1 34  ? -20.15041 -51.95242 11.36534  1.000 27.04057 ? 34  ASP A CB   1 
ATOM   496  C CG   . ASP A 1 34  ? -21.66550 -51.91677 11.52117  1.000 30.74549 ? 34  ASP A CG   1 
ATOM   497  O OD1  . ASP A 1 34  ? -22.17639 -50.93756 12.10785  1.000 25.28053 ? 34  ASP A OD1  1 
ATOM   498  O OD2  . ASP A 1 34  ? -22.34134 -52.86217 11.04595  1.000 29.87267 ? 34  ASP A OD2  1 
ATOM   499  H H    . ASP A 1 34  ? -20.59595 -50.31609 13.29774  1.000 29.01274 ? 34  ASP A H    1 
ATOM   500  H HA   . ASP A 1 34  ? -18.52737 -50.73305 11.60254  1.000 29.69282 ? 34  ASP A HA   1 
ATOM   501  H HB2  . ASP A 1 34  ? -19.94963 -52.19253 10.44723  1.000 32.49898 ? 34  ASP A HB2  1 
ATOM   502  H HB3  . ASP A 1 34  ? -19.80343 -52.62824 11.96847  1.000 32.49898 ? 34  ASP A HB3  1 
ATOM   503  N N    . VAL A 1 35  ? -19.81798 -48.27923 11.03959  1.000 24.62267 ? 35  VAL A N    1 
ATOM   504  C CA   . VAL A 1 35  ? -20.26553 -47.19787 10.18129  1.000 23.20937 ? 35  VAL A CA   1 
ATOM   505  C C    . VAL A 1 35  ? -19.17528 -46.14930 10.10531  1.000 21.37755 ? 35  VAL A C    1 
ATOM   506  O O    . VAL A 1 35  ? -18.54515 -45.81603 11.11490  1.000 21.84882 ? 35  VAL A O    1 
ATOM   507  C CB   . VAL A 1 35  ? -21.57613 -46.56281 10.68349  1.000 23.78499 ? 35  VAL A CB   1 
ATOM   508  C CG1  . VAL A 1 35  ? -21.94172 -45.39010 9.79805   1.000 23.85146 ? 35  VAL A CG1  1 
ATOM   509  C CG2  . VAL A 1 35  ? -22.67343 -47.60344 10.70543  1.000 23.93773 ? 35  VAL A CG2  1 
ATOM   510  H H    . VAL A 1 35  ? -19.49811 -48.01722 11.79368  1.000 29.59749 ? 35  VAL A H    1 
ATOM   511  H HA   . VAL A 1 35  ? -20.41820 -47.55312 9.29169   1.000 27.90154 ? 35  VAL A HA   1 
ATOM   512  H HB   . VAL A 1 35  ? -21.46493 -46.23179 11.58845  1.000 28.59228 ? 35  VAL A HB   1 
ATOM   513  H HG11 . VAL A 1 35  ? -22.85445 -45.12282 9.98884   1.000 28.67204 ? 35  VAL A HG11 1 
ATOM   514  H HG12 . VAL A 1 35  ? -21.33642 -44.65478 9.98194   1.000 28.67204 ? 35  VAL A HG12 1 
ATOM   515  H HG13 . VAL A 1 35  ? -21.86304 -45.65897 8.86939   1.000 28.67204 ? 35  VAL A HG13 1 
ATOM   516  H HG21 . VAL A 1 35  ? -23.44759 -47.23650 11.16033  1.000 28.77557 ? 35  VAL A HG21 1 
ATOM   517  H HG22 . VAL A 1 35  ? -22.90570 -47.83673 9.79300   1.000 28.77557 ? 35  VAL A HG22 1 
ATOM   518  H HG23 . VAL A 1 35  ? -22.35436 -48.38893 11.17669  1.000 28.77557 ? 35  VAL A HG23 1 
ATOM   519  N N    . VAL A 1 36  ? -18.95988 -45.61919 8.90867   1.000 21.09398 ? 36  VAL A N    1 
ATOM   520  C CA   . VAL A 1 36  ? -18.03471 -44.52636 8.68935   1.000 20.57929 ? 36  VAL A CA   1 
ATOM   521  C C    . VAL A 1 36  ? -18.85236 -43.33625 8.21797   1.000 20.79740 ? 36  VAL A C    1 
ATOM   522  O O    . VAL A 1 36  ? -19.54396 -43.41728 7.19531   1.000 19.62019 ? 36  VAL A O    1 
ATOM   523  C CB   . VAL A 1 36  ? -16.93956 -44.88061 7.67088   1.000 21.72811 ? 36  VAL A CB   1 
ATOM   524  C CG1  . VAL A 1 36  ? -16.05976 -43.65335 7.39479   1.000 20.54850 ? 36  VAL A CG1  1 
ATOM   525  C CG2  . VAL A 1 36  ? -16.09115 -46.04833 8.18146   1.000 22.76127 ? 36  VAL A CG2  1 
ATOM   526  H H    . VAL A 1 36  ? -19.35107 -45.88621 8.19084   1.000 25.36307 ? 36  VAL A H    1 
ATOM   527  H HA   . VAL A 1 36  ? -17.59718 -44.29994 9.52493   1.000 24.74543 ? 36  VAL A HA   1 
ATOM   528  H HB   . VAL A 1 36  ? -17.35539 -45.15338 6.83806   1.000 26.12403 ? 36  VAL A HB   1 
ATOM   529  H HG11 . VAL A 1 36  ? -16.58169 -42.99248 6.91339   1.000 24.70849 ? 36  VAL A HG11 1 
ATOM   530  H HG12 . VAL A 1 36  ? -15.75767 -43.28484 8.23967   1.000 24.70849 ? 36  VAL A HG12 1 
ATOM   531  H HG13 . VAL A 1 36  ? -15.29694 -43.92531 6.86089   1.000 24.70849 ? 36  VAL A HG13 1 
ATOM   532  H HG21 . VAL A 1 36  ? -15.54542 -46.38427 7.45329   1.000 27.36381 ? 36  VAL A HG21 1 
ATOM   533  H HG22 . VAL A 1 36  ? -15.52353 -45.73460 8.90276   1.000 27.36381 ? 36  VAL A HG22 1 
ATOM   534  H HG23 . VAL A 1 36  ? -16.67950 -46.74871 8.50427   1.000 27.36381 ? 36  VAL A HG23 1 
ATOM   535  N N    . TYR A 1 37  ? -18.77887 -42.24201 8.96577   1.000 20.15587 ? 37  TYR A N    1 
ATOM   536  C CA   . TYR A 1 37  ? -19.47507 -41.00460 8.65104   1.000 20.02058 ? 37  TYR A CA   1 
ATOM   537  C C    . TYR A 1 37  ? -18.50615 -40.05894 7.95817   1.000 19.99700 ? 37  TYR A C    1 
ATOM   538  O O    . TYR A 1 37  ? -17.39203 -39.85844 8.45023   1.000 20.22322 ? 37  TYR A O    1 
ATOM   539  C CB   . TYR A 1 37  ? -19.99988 -40.35170 9.93020   1.000 20.35506 ? 37  TYR A CB   1 
ATOM   540  C CG   . TYR A 1 37  ? -20.87050 -41.26538 10.74844  1.000 21.84366 ? 37  TYR A CG   1 
ATOM   541  C CD1  . TYR A 1 37  ? -20.31329 -42.25394 11.54519  1.000 21.85322 ? 37  TYR A CD1  1 
ATOM   542  C CD2  . TYR A 1 37  ? -22.25073 -41.14916 10.71239  1.000 22.16966 ? 37  TYR A CD2  1 
ATOM   543  C CE1  . TYR A 1 37  ? -21.09831 -43.09809 12.28074  1.000 23.52503 ? 37  TYR A CE1  1 
ATOM   544  C CE2  . TYR A 1 37  ? -23.04939 -41.99318 11.45160  1.000 25.04086 ? 37  TYR A CE2  1 
ATOM   545  C CZ   . TYR A 1 37  ? -22.46242 -42.96361 12.23941  1.000 25.44950 ? 37  TYR A CZ   1 
ATOM   546  O OH   . TYR A 1 37  ? -23.23098 -43.82228 12.98795  1.000 24.73125 ? 37  TYR A OH   1 
ATOM   547  H H    . TYR A 1 37  ? -18.31400 -42.19135 9.68753   1.000 24.23733 ? 37  TYR A H    1 
ATOM   548  H HA   . TYR A 1 37  ? -20.22293 -41.18417 8.05997   1.000 24.07499 ? 37  TYR A HA   1 
ATOM   549  H HB2  . TYR A 1 37  ? -19.24566 -40.08707 10.47978  1.000 24.47636 ? 37  TYR A HB2  1 
ATOM   550  H HB3  . TYR A 1 37  ? -20.52620 -39.57256 9.69179   1.000 24.47636 ? 37  TYR A HB3  1 
ATOM   551  H HD1  . TYR A 1 37  ? -19.38837 -42.34458 11.57999  1.000 26.27416 ? 37  TYR A HD1  1 
ATOM   552  H HD2  . TYR A 1 37  ? -22.64266 -40.49307 10.18244  1.000 26.65388 ? 37  TYR A HD2  1 
ATOM   553  H HE1  . TYR A 1 37  ? -20.70933 -43.75965 12.80603  1.000 28.28032 ? 37  TYR A HE1  1 
ATOM   554  H HE2  . TYR A 1 37  ? -23.97517 -41.91037 11.42051  1.000 30.09932 ? 37  TYR A HE2  1 
ATOM   555  H HH   . TYR A 1 37  ? -22.74476 -44.25285 13.52067  1.000 29.72778 ? 37  TYR A HH   1 
ATOM   556  N N    . CYS A 1 38  ? -18.91519 -39.46215 6.84541   1.000 18.58369 ? 38  CYS A N    1 
ATOM   557  C CA   . CYS A 1 38  ? -18.07014 -38.45516 6.21349   1.000 19.61222 ? 38  CYS A CA   1 
ATOM   558  C C    . CYS A 1 38  ? -18.92079 -37.43916 5.48005   1.000 20.10662 ? 38  CYS A C    1 
ATOM   559  O O    . CYS A 1 38  ? -20.10425 -37.67125 5.20568   1.000 20.51125 ? 38  CYS A O    1 
ATOM   560  C CB   . CYS A 1 38  ? -17.05662 -39.09195 5.25881   1.000 19.15554 ? 38  CYS A CB   1 
ATOM   561  S SG   . CYS A 1 38  ? -17.77478 -39.80505 3.75967   1.000 21.23240 ? 38  CYS A SG   1 
ATOM   562  H H    . CYS A 1 38  ? -19.66043 -39.61895 6.44588   1.000 22.35072 ? 38  CYS A H    1 
ATOM   563  H HA   . CYS A 1 38  ? -17.59602 -37.97860 6.91278   1.000 23.58496 ? 38  CYS A HA   1 
ATOM   564  H HB2  . CYS A 1 38  ? -16.42263 -38.41124 4.98384   1.000 23.03694 ? 38  CYS A HB2  1 
ATOM   565  H HB3  . CYS A 1 38  ? -16.59561 -39.80404 5.72922   1.000 23.03694 ? 38  CYS A HB3  1 
ATOM   566  H HG   . CYS A 1 38  ? -16.92617 -39.87263 2.91392   1.000 25.52916 ? 38  CYS A HG   1 
ATOM   567  N N    . PRO A 1 39  ? -18.33632 -36.29335 5.11929   1.000 20.25239 ? 39  PRO A N    1 
ATOM   568  C CA   . PRO A 1 39  ? -19.06085 -35.31776 4.29137   1.000 18.28267 ? 39  PRO A CA   1 
ATOM   569  C C    . PRO A 1 39  ? -19.44238 -35.89923 2.93531   1.000 20.52624 ? 39  PRO A C    1 
ATOM   570  O O    . PRO A 1 39  ? -18.63765 -36.54694 2.26280   1.000 19.78073 ? 39  PRO A O    1 
ATOM   571  C CB   . PRO A 1 39  ? -18.06216 -34.16406 4.14010   1.000 18.92220 ? 39  PRO A CB   1 
ATOM   572  C CG   . PRO A 1 39  ? -17.10607 -34.33463 5.28751   1.000 20.17353 ? 39  PRO A CG   1 
ATOM   573  C CD   . PRO A 1 39  ? -16.99022 -35.81524 5.48608   1.000 20.64895 ? 39  PRO A CD   1 
ATOM   574  H HA   . PRO A 1 39  ? -19.85772 -35.01134 4.75182   1.000 21.98949 ? 39  PRO A HA   1 
ATOM   575  H HB2  . PRO A 1 39  ? -17.60132 -34.23405 3.28944   1.000 22.75692 ? 39  PRO A HB2  1 
ATOM   576  H HB3  . PRO A 1 39  ? -18.52639 -33.31427 4.19700   1.000 22.75692 ? 39  PRO A HB3  1 
ATOM   577  H HG2  . PRO A 1 39  ? -16.24603 -33.94779 5.06039   1.000 24.25853 ? 39  PRO A HG2  1 
ATOM   578  H HG3  . PRO A 1 39  ? -17.46343 -33.90616 6.08099   1.000 24.25853 ? 39  PRO A HG3  1 
ATOM   579  H HD2  . PRO A 1 39  ? -16.31510 -36.19322 4.90106   1.000 24.82903 ? 39  PRO A HD2  1 
ATOM   580  H HD3  . PRO A 1 39  ? -16.78510 -36.02761 6.41006   1.000 24.82903 ? 39  PRO A HD3  1 
ATOM   581  N N    . ARG A 1 40  ? -20.67911 -35.63608 2.52426   1.000 19.91278 ? 40  ARG A N    1 
ATOM   582  C CA   . ARG A 1 40  ? -21.12484 -36.14174 1.23402   1.000 20.41230 ? 40  ARG A CA   1 
ATOM   583  C C    . ARG A 1 40  ? -20.33636 -35.55701 0.05726   1.000 21.30088 ? 40  ARG A C    1 
ATOM   584  O O    . ARG A 1 40  ? -20.26670 -36.21176 -0.99104  1.000 21.94916 ? 40  ARG A O    1 
ATOM   585  C CB   . ARG A 1 40  ? -22.63093 -35.89521 1.06153   1.000 21.38670 ? 40  ARG A CB   1 
ATOM   586  C CG   . ARG A 1 40  ? -23.09555 -34.45008 0.92191   1.000 20.84136 ? 40  ARG A CG   1 
ATOM   587  C CD   . ARG A 1 40  ? -24.58692 -34.44675 0.63675   1.000 21.32195 ? 40  ARG A CD   1 
ATOM   588  N NE   . ARG A 1 40  ? -25.12970 -33.09823 0.68506   1.000 23.01602 ? 40  ARG A NE   1 
ATOM   589  C CZ   . ARG A 1 40  ? -26.36818 -32.77821 0.35310   1.000 24.77490 ? 40  ARG A CZ   1 
ATOM   590  N NH1  . ARG A 1 40  ? -27.24695 -33.69682 -0.01607  1.000 23.16936 ? 40  ARG A NH1  1 
ATOM   591  N NH2  . ARG A 1 40  ? -26.73443 -31.50064 0.37348   1.000 23.29461 ? 40  ARG A NH2  1 
ATOM   592  H H    . ARG A 1 40  ? -21.26238 -35.18001 2.96176   1.000 23.94563 ? 40  ARG A H    1 
ATOM   593  H HA   . ARG A 1 40  ? -20.98219 -37.10100 1.21467   1.000 24.54504 ? 40  ARG A HA   1 
ATOM   594  H HB2  . ARG A 1 40  ? -22.91851 -36.36054 0.26049   1.000 25.71432 ? 40  ARG A HB2  1 
ATOM   595  H HB3  . ARG A 1 40  ? -23.08287 -36.26097 1.83798   1.000 25.71432 ? 40  ARG A HB3  1 
ATOM   596  H HG2  . ARG A 1 40  ? -22.92929 -33.96642 1.74613   1.000 25.05992 ? 40  ARG A HG2  1 
ATOM   597  H HG3  . ARG A 1 40  ? -22.63113 -34.02127 0.18616   1.000 25.05992 ? 40  ARG A HG3  1 
ATOM   598  H HD2  . ARG A 1 40  ? -24.74634 -34.80939 -0.24867  1.000 25.63663 ? 40  ARG A HD2  1 
ATOM   599  H HD3  . ARG A 1 40  ? -25.04335 -34.98451 1.30263   1.000 25.63663 ? 40  ARG A HD3  1 
ATOM   600  H HE   . ARG A 1 40  ? -24.60916 -32.46599 0.94756   1.000 27.66951 ? 40  ARG A HE   1 
ATOM   601  H HH11 . ARG A 1 40  ? -27.01711 -34.52507 -0.04414  1.000 27.85352 ? 40  ARG A HH11 1 
ATOM   602  H HH12 . ARG A 1 40  ? -28.04769 -33.46537 -0.22784  1.000 27.85352 ? 40  ARG A HH12 1 
ATOM   603  H HH21 . ARG A 1 40  ? -26.16817 -30.89455 0.60066   1.000 28.00382 ? 40  ARG A HH21 1 
ATOM   604  H HH22 . ARG A 1 40  ? -27.53766 -31.28012 0.15948   1.000 28.00382 ? 40  ARG A HH22 1 
ATOM   605  N N    . HIS A 1 41  ? -19.71642 -34.38870 0.18361   1.000 19.51432 ? 41  HIS A N    1 
ATOM   606  C CA   . HIS A 1 41  ? -19.04003 -33.86443 -1.01514  1.000 21.35706 ? 41  HIS A CA   1 
ATOM   607  C C    . HIS A 1 41  ? -17.76524 -34.64662 -1.36416  1.000 22.39979 ? 41  HIS A C    1 
ATOM   608  O O    . HIS A 1 41  ? -17.08841 -34.28692 -2.33098  1.000 22.88239 ? 41  HIS A O    1 
ATOM   609  C CB   . HIS A 1 41  ? -18.75198 -32.36435 -0.88060  1.000 20.43641 ? 41  HIS A CB   1 
ATOM   610  C CG   . HIS A 1 41  ? -17.64897 -31.99633 0.06809   1.000 20.24184 ? 41  HIS A CG   1 
ATOM   611  N ND1  . HIS A 1 41  ? -17.89061 -31.48261 1.32556   1.000 20.71882 ? 41  HIS A ND1  1 
ATOM   612  C CD2  . HIS A 1 41  ? -16.30425 -31.96903 -0.09086  1.000 20.14690 ? 41  HIS A CD2  1 
ATOM   613  C CE1  . HIS A 1 41  ? -16.74578 -31.19113 1.91195   1.000 21.12670 ? 41  HIS A CE1  1 
ATOM   614  N NE2  . HIS A 1 41  ? -15.76457 -31.49121 1.07949   1.000 20.37613 ? 41  HIS A NE2  1 
ATOM   615  H H    . HIS A 1 41  ? -19.67223 -33.91008 0.89675   1.000 23.46748 ? 41  HIS A H    1 
ATOM   616  H HA   . HIS A 1 41  ? -19.64544 -33.94852 -1.76834  1.000 25.67877 ? 41  HIS A HA   1 
ATOM   617  H HB2  . HIS A 1 41  ? -18.50626 -32.02203 -1.75429  1.000 24.57398 ? 41  HIS A HB2  1 
ATOM   618  H HB3  . HIS A 1 41  ? -19.55886 -31.92634 -0.56758  1.000 24.57398 ? 41  HIS A HB3  1 
ATOM   619  H HD2  . HIS A 1 41  ? -15.83349 -32.22586 -0.85068  1.000 24.22657 ? 41  HIS A HD2  1 
ATOM   620  H HE1  . HIS A 1 41  ? -16.64618 -30.83526 2.76537   1.000 25.40233 ? 41  HIS A HE1  1 
ATOM   621  H HE2  . HIS A 1 41  ? -14.92502 -31.40209 1.24324   1.000 24.50165 ? 41  HIS A HE2  1 
ATOM   622  N N    . VAL A 1 42  ? -17.46230 -35.72156 -0.64136  1.000 21.50975 ? 42  VAL A N    1 
ATOM   623  C CA   . VAL A 1 42  ? -16.41179 -36.62038 -1.10059  1.000 22.30485 ? 42  VAL A CA   1 
ATOM   624  C C    . VAL A 1 42  ? -16.72989 -37.20966 -2.46965  1.000 25.37147 ? 42  VAL A C    1 
ATOM   625  O O    . VAL A 1 42  ? -15.82159 -37.65827 -3.17674  1.000 23.69015 ? 42  VAL A O    1 
ATOM   626  C CB   . VAL A 1 42  ? -16.18211 -37.74708 -0.06887  1.000 22.30289 ? 42  VAL A CB   1 
ATOM   627  C CG1  . VAL A 1 42  ? -17.34270 -38.73962 -0.05204  1.000 22.23504 ? 42  VAL A CG1  1 
ATOM   628  C CG2  . VAL A 1 42  ? -14.87762 -38.47691 -0.36714  1.000 22.51714 ? 42  VAL A CG2  1 
ATOM   629  H H    . VAL A 1 42  ? -17.84021 -35.94579 0.09790   1.000 25.86199 ? 42  VAL A H    1 
ATOM   630  H HA   . VAL A 1 42  ? -15.59304 -36.10624 -1.17948  1.000 26.81612 ? 42  VAL A HA   1 
ATOM   631  H HB   . VAL A 1 42  ? -16.12690 -37.34223 0.81087   1.000 26.81375 ? 42  VAL A HB   1 
ATOM   632  H HG11 . VAL A 1 42  ? -17.42657 -39.14237 -0.93048  1.000 26.73234 ? 42  VAL A HG11 1 
ATOM   633  H HG12 . VAL A 1 42  ? -17.16249 -39.42503 0.61025   1.000 26.73234 ? 42  VAL A HG12 1 
ATOM   634  H HG13 . VAL A 1 42  ? -18.15901 -38.26718 0.17455   1.000 26.73234 ? 42  VAL A HG13 1 
ATOM   635  H HG21 . VAL A 1 42  ? -14.49887 -38.12420 -1.18753  1.000 27.07086 ? 42  VAL A HG21 1 
ATOM   636  H HG22 . VAL A 1 42  ? -14.26163 -38.33622 0.36883   1.000 27.07086 ? 42  VAL A HG22 1 
ATOM   637  H HG23 . VAL A 1 42  ? -15.06155 -39.42395 -0.46812  1.000 27.07086 ? 42  VAL A HG23 1 
ATOM   638  N N    . ILE A 1 43  ? -18.00952 -37.23302 -2.86179  1.000 23.70190 ? 43  ILE A N    1 
ATOM   639  C CA   . ILE A 1 43  ? -18.37392 -37.76886 -4.17494  1.000 24.09448 ? 43  ILE A CA   1 
ATOM   640  C C    . ILE A 1 43  ? -18.24472 -36.73600 -5.28441  1.000 27.99182 ? 43  ILE A C    1 
ATOM   641  O O    . ILE A 1 43  ? -18.45361 -37.07489 -6.45547  1.000 28.44707 ? 43  ILE A O    1 
ATOM   642  C CB   . ILE A 1 43  ? -19.81084 -38.33900 -4.14864  1.000 23.25547 ? 43  ILE A CB   1 
ATOM   643  C CG1  . ILE A 1 43  ? -20.84571 -37.20959 -4.09725  1.000 23.58782 ? 43  ILE A CG1  1 
ATOM   644  C CG2  . ILE A 1 43  ? -19.97598 -39.30770 -2.96840  1.000 25.90326 ? 43  ILE A CG2  1 
ATOM   645  C CD1  . ILE A 1 43  ? -22.29428 -37.69725 -4.00493  1.000 23.66625 ? 43  ILE A CD1  1 
ATOM   646  H H    . ILE A 1 43  ? -18.67218 -36.94913 -2.39287  1.000 28.49258 ? 43  ILE A H    1 
ATOM   647  H HA   . ILE A 1 43  ? -17.76605 -38.49403 -4.38830  1.000 28.96367 ? 43  ILE A HA   1 
ATOM   648  H HB   . ILE A 1 43  ? -19.96153 -38.83325 -4.96956  1.000 27.95686 ? 43  ILE A HB   1 
ATOM   649  H HG12 . ILE A 1 43  ? -20.66874 -36.66074 -3.31729  1.000 28.35567 ? 43  ILE A HG12 1 
ATOM   650  H HG13 . ILE A 1 43  ? -20.76456 -36.67637 -4.90348  1.000 28.35567 ? 43  ILE A HG13 1 
ATOM   651  H HG21 . ILE A 1 43  ? -19.94384 -38.80436 -2.13984  1.000 31.13420 ? 43  ILE A HG21 1 
ATOM   652  H HG22 . ILE A 1 43  ? -20.83058 -39.75962 -3.04796  1.000 31.13420 ? 43  ILE A HG22 1 
ATOM   653  H HG23 . ILE A 1 43  ? -19.25538 -39.95671 -2.98933  1.000 31.13420 ? 43  ILE A HG23 1 
ATOM   654  H HD11 . ILE A 1 43  ? -22.39964 -38.22285 -3.19652  1.000 28.44979 ? 43  ILE A HD11 1 
ATOM   655  H HD12 . ILE A 1 43  ? -22.88525 -36.92849 -3.97903  1.000 28.44979 ? 43  ILE A HD12 1 
ATOM   656  H HD13 . ILE A 1 43  ? -22.49421 -38.24212 -4.78214  1.000 28.44979 ? 43  ILE A HD13 1 
ATOM   657  N N    . CYS A 1 44  ? -17.87698 -35.50224 -4.95971  1.000 25.49892 ? 44  CYS A N    1 
ATOM   658  C CA   . CYS A 1 44  ? -17.75172 -34.45217 -5.95371  1.000 27.89787 ? 44  CYS A CA   1 
ATOM   659  C C    . CYS A 1 44  ? -16.33653 -34.38489 -6.49949  1.000 35.00949 ? 44  CYS A C    1 
ATOM   660  O O    . CYS A 1 44  ? -15.36415 -34.50194 -5.74918  1.000 30.64114 ? 44  CYS A O    1 
ATOM   661  C CB   . CYS A 1 44  ? -18.09411 -33.08788 -5.35774  1.000 28.89223 ? 44  CYS A CB   1 
ATOM   662  S SG   . CYS A 1 44  ? -19.76805 -32.90263 -4.75676  1.000 26.62316 ? 44  CYS A SG   1 
ATOM   663  H H    . CYS A 1 44  ? -17.69279 -35.24803 -4.15906  1.000 30.64900 ? 44  CYS A H    1 
ATOM   664  H HA   . CYS A 1 44  ? -18.36518 -34.65237 -6.67793  1.000 33.52773 ? 44  CYS A HA   1 
ATOM   665  H HB2  . CYS A 1 44  ? -17.49959 -32.92525 -4.60874  1.000 34.72096 ? 44  CYS A HB2  1 
ATOM   666  H HB3  . CYS A 1 44  ? -17.95760 -32.41408 -6.04204  1.000 34.72096 ? 44  CYS A HB3  1 
ATOM   667  H HG   . CYS A 1 44  ? -19.92886 -31.77109 -4.39103  1.000 31.99808 ? 44  CYS A HG   1 
ATOM   668  N N    . THR A 1 45  ? -16.23033 -34.16952 -7.80307  1.000 34.51494 ? 45  THR A N    1 
ATOM   669  C CA   . THR A 1 45  ? -15.01723 -33.61496 -8.37341  1.000 43.75318 ? 45  THR A CA   1 
ATOM   670  C C    . THR A 1 45  ? -14.97749 -32.11514 -8.09209  1.000 48.88297 ? 45  THR A C    1 
ATOM   671  O O    . THR A 1 45  ? -15.96528 -31.51061 -7.66553  1.000 43.09082 ? 45  THR A O    1 
ATOM   672  C CB   . THR A 1 45  ? -14.97270 -33.87311 -9.87062  1.000 48.64209 ? 45  THR A CB   1 
ATOM   673  O OG1  . THR A 1 45  ? -15.98251 -33.08287 -10.50729 1.000 49.82699 ? 45  THR A OG1  1 
ATOM   674  C CG2  . THR A 1 45  ? -15.22673 -35.34838 -10.14916 1.000 48.31099 ? 45  THR A CG2  1 
ATOM   675  H H    . THR A 1 45  ? -16.84817 -34.33688 -8.37742  1.000 41.46822 ? 45  THR A H    1 
ATOM   676  H HA   . THR A 1 45  ? -14.23785 -34.03506 -7.97719  1.000 52.55410 ? 45  THR A HA   1 
ATOM   677  H HB   . THR A 1 45  ? -14.10270 -33.63842 -10.22968 1.000 58.42079 ? 45  THR A HB   1 
ATOM   678  H HG1  . THR A 1 45  ? -15.63413 -32.58328 -11.08577 1.000 59.84267 ? 45  THR A HG1  1 
ATOM   679  H HG21 . THR A 1 45  ? -14.94245 -35.88285 -9.39125  1.000 58.02348 ? 45  THR A HG21 1 
ATOM   680  H HG22 . THR A 1 45  ? -16.17250 -35.49883 -10.30339 1.000 58.02348 ? 45  THR A HG22 1 
ATOM   681  H HG23 . THR A 1 45  ? -14.73129 -35.62777 -10.93489 1.000 58.02348 ? 45  THR A HG23 1 
ATOM   682  N N    . SER A 1 46  ? -13.82094 -31.50237 -8.33946  1.000 58.70481 ? 46  SER A N    1 
ATOM   683  C CA   . SER A 1 46  ? -13.70338 -30.07268 -8.07550  1.000 60.78285 ? 46  SER A CA   1 
ATOM   684  C C    . SER A 1 46  ? -14.73921 -29.28650 -8.86382  1.000 57.44612 ? 46  SER A C    1 
ATOM   685  O O    . SER A 1 46  ? -15.32038 -28.32353 -8.35134  1.000 53.06709 ? 46  SER A O    1 
ATOM   686  C CB   . SER A 1 46  ? -12.29918 -29.58407 -8.41164  1.000 68.34371 ? 46  SER A CB   1 
ATOM   687  O OG   . SER A 1 46  ? -11.34639 -30.26538 -7.62374  1.000 68.15075 ? 46  SER A OG   1 
ATOM   688  H H    . SER A 1 46  ? -13.11304 -31.87937 -8.64987  1.000 70.49606 ? 46  SER A H    1 
ATOM   689  H HA   . SER A 1 46  ? -13.85423 -29.91827 -7.12982  1.000 72.98971 ? 46  SER A HA   1 
ATOM   690  H HB2  . SER A 1 46  ? -12.11824 -29.75499 -9.34916  1.000 82.06275 ? 46  SER A HB2  1 
ATOM   691  H HB3  . SER A 1 46  ? -12.24090 -28.63291 -8.23054  1.000 82.06275 ? 46  SER A HB3  1 
ATOM   692  H HG   . SER A 1 46  ? -10.83079 -30.70931 -8.11638  1.000 81.83118 ? 46  SER A HG   1 
ATOM   693  N N    . GLU A 1 47  ? -14.98860 -29.68874 -10.11229 1.000 56.82261 ? 47  GLU A N    1 
ATOM   694  C CA   . GLU A 1 47  ? -15.98520 -28.99970 -10.92420 1.000 58.22871 ? 47  GLU A CA   1 
ATOM   695  C C    . GLU A 1 47  ? -17.37586 -29.12307 -10.31306 1.000 51.66978 ? 47  GLU A C    1 
ATOM   696  O O    . GLU A 1 47  ? -18.12827 -28.14295 -10.26731 1.000 49.06178 ? 47  GLU A O    1 
ATOM   697  C CB   . GLU A 1 47  ? -15.97631 -29.55388 -12.34939 1.000 49.18267 ? 47  GLU A CB   1 
ATOM   698  H H    . GLU A 1 47  ? -14.59961 -30.34770 -10.50480 1.000 68.23742 ? 47  GLU A H    1 
ATOM   699  H HA   . GLU A 1 47  ? -15.75635 -28.05800 -10.96574 1.000 69.92474 ? 47  GLU A HA   1 
ATOM   700  N N    . ASP A 1 48  ? -17.73228 -30.31639 -9.82644  1.000 47.37157 ? 48  ASP A N    1 
ATOM   701  C CA   . ASP A 1 48  ? -19.07134 -30.52091 -9.29186  1.000 45.00777 ? 48  ASP A CA   1 
ATOM   702  C C    . ASP A 1 48  ? -19.38502 -29.60803 -8.11107  1.000 38.79861 ? 48  ASP A C    1 
ATOM   703  O O    . ASP A 1 48  ? -20.56319 -29.36957 -7.82746  1.000 36.41790 ? 48  ASP A O    1 
ATOM   704  C CB   . ASP A 1 48  ? -19.27091 -31.96293 -8.81461  1.000 42.73533 ? 48  ASP A CB   1 
ATOM   705  C CG   . ASP A 1 48  ? -19.18476 -32.97511 -9.92945  1.000 47.73734 ? 48  ASP A CG   1 
ATOM   706  O OD1  . ASP A 1 48  ? -19.58923 -32.67196 -11.07115 1.000 53.45406 ? 48  ASP A OD1  1 
ATOM   707  O OD2  . ASP A 1 48  ? -18.71881 -34.09573 -9.64212  1.000 43.52194 ? 48  ASP A OD2  1 
ATOM   708  H H    . ASP A 1 48  ? -17.22313 -31.00885 -9.79683  1.000 56.89618 ? 48  ASP A H    1 
ATOM   709  H HA   . ASP A 1 48  ? -19.68541 -30.33839 -10.02021 1.000 54.05961 ? 48  ASP A HA   1 
ATOM   710  H HB2  . ASP A 1 48  ? -18.58381 -32.17675 -8.16417  1.000 51.33269 ? 48  ASP A HB2  1 
ATOM   711  H HB3  . ASP A 1 48  ? -20.14823 -32.04104 -8.40828  1.000 51.33269 ? 48  ASP A HB3  1 
ATOM   712  N N    . MET A 1 49  ? -18.37228 -29.10958 -7.40272  1.000 39.62159 ? 49  MET A N    1 
ATOM   713  C CA   . MET A 1 49  ? -18.62982 -28.49447 -6.10274  1.000 35.87652 ? 49  MET A CA   1 
ATOM   714  C C    . MET A 1 49  ? -19.31268 -27.13327 -6.19628  1.000 33.77769 ? 49  MET A C    1 
ATOM   715  O O    . MET A 1 49  ? -19.80858 -26.64366 -5.17779  1.000 31.70429 ? 49  MET A O    1 
ATOM   716  C CB   . MET A 1 49  ? -17.31569 -28.40294 -5.31794  1.000 35.68651 ? 49  MET A CB   1 
ATOM   717  C CG   . MET A 1 49  ? -16.80895 -29.77239 -4.84192  1.000 38.53516 ? 49  MET A CG   1 
ATOM   718  S SD   . MET A 1 49  ? -15.21742 -29.70111 -3.99858  1.000 38.47898 ? 49  MET A SD   1 
ATOM   719  C CE   . MET A 1 49  ? -14.86408 -31.44310 -3.78307  1.000 29.58368 ? 49  MET A CE   1 
ATOM   720  H H    . MET A 1 49  ? -17.54768 -29.11520 -7.64687  1.000 47.59620 ? 49  MET A H    1 
ATOM   721  H HA   . MET A 1 49  ? -19.22864 -29.06802 -5.59940  1.000 43.10211 ? 49  MET A HA   1 
ATOM   722  H HB2  . MET A 1 49  ? -16.63466 -28.01252 -5.88773  1.000 42.87411 ? 49  MET A HB2  1 
ATOM   723  H HB3  . MET A 1 49  ? -17.45351 -27.84568 -4.53604  1.000 42.87411 ? 49  MET A HB3  1 
ATOM   724  H HG2  . MET A 1 49  ? -17.45536 -30.14722 -4.22342  1.000 46.29248 ? 49  MET A HG2  1 
ATOM   725  H HG3  . MET A 1 49  ? -16.71040 -30.35416 -5.61181  1.000 46.29248 ? 49  MET A HG3  1 
ATOM   726  H HE1  . MET A 1 49  ? -15.43348 -31.79642 -3.08176  1.000 35.55070 ? 49  MET A HE1  1 
ATOM   727  H HE2  . MET A 1 49  ? -15.03997 -31.90652 -4.61686  1.000 35.55070 ? 49  MET A HE2  1 
ATOM   728  H HE3  . MET A 1 49  ? -13.93182 -31.54810 -3.53657  1.000 35.55070 ? 49  MET A HE3  1 
ATOM   729  N N    . PHE A 1 50  ? -19.41060 -26.53386 -7.38308  1.000 31.94477 ? 50  PHE A N    1 
ATOM   730  C CA   . PHE A 1 50  ? -20.07192 -25.23267 -7.47021  1.000 34.09764 ? 50  PHE A CA   1 
ATOM   731  C C    . PHE A 1 50  ? -21.59184 -25.35969 -7.50467  1.000 36.16682 ? 50  PHE A C    1 
ATOM   732  O O    . PHE A 1 50  ? -22.28677 -24.45071 -7.03782  1.000 38.35468 ? 50  PHE A O    1 
ATOM   733  C CB   . PHE A 1 50  ? -19.53502 -24.46299 -8.67908  1.000 38.31143 ? 50  PHE A CB   1 
ATOM   734  C CG   . PHE A 1 50  ? -18.06104 -24.15292 -8.57037  1.000 36.83160 ? 50  PHE A CG   1 
ATOM   735  C CD1  . PHE A 1 50  ? -17.61627 -23.11495 -7.76563  1.000 36.40082 ? 50  PHE A CD1  1 
ATOM   736  C CD2  . PHE A 1 50  ? -17.12012 -24.92378 -9.23405  1.000 40.08949 ? 50  PHE A CD2  1 
ATOM   737  C CE1  . PHE A 1 50  ? -16.26559 -22.84273 -7.63561  1.000 34.35788 ? 50  PHE A CE1  1 
ATOM   738  C CE2  . PHE A 1 50  ? -15.76704 -24.65136 -9.10929  1.000 39.89894 ? 50  PHE A CE2  1 
ATOM   739  C CZ   . PHE A 1 50  ? -15.34144 -23.61008 -8.30534  1.000 35.83160 ? 50  PHE A CZ   1 
ATOM   740  H H    . PHE A 1 50  ? -19.11319 -26.84791 -8.12640  1.000 38.38402 ? 50  PHE A H    1 
ATOM   741  H HA   . PHE A 1 50  ? -19.86038 -24.70677 -6.68308  1.000 40.96745 ? 50  PHE A HA   1 
ATOM   742  N N    . ASN A 1 51  ? -22.12912 -26.47202 -7.99867  1.000 33.25079 ? 51  ASN A N    1 
ATOM   743  C CA   . ASN A 1 51  ? -23.57634 -26.66023 -7.99454  1.000 37.30559 ? 51  ASN A CA   1 
ATOM   744  C C    . ASN A 1 51  ? -23.89014 -28.14757 -8.04687  1.000 35.06027 ? 51  ASN A C    1 
ATOM   745  O O    . ASN A 1 51  ? -24.45355 -28.63815 -9.03495  1.000 35.11549 ? 51  ASN A O    1 
ATOM   746  C CB   . ASN A 1 51  ? -24.23416 -25.93971 -9.16916  1.000 44.47725 ? 51  ASN A CB   1 
ATOM   747  C CG   . ASN A 1 51  ? -25.72306 -25.73933 -8.95599  1.000 56.31805 ? 51  ASN A CG   1 
ATOM   748  O OD1  . ASN A 1 51  ? -26.22974 -25.91738 -7.84642  1.000 52.57801 ? 51  ASN A OD1  1 
ATOM   749  N ND2  . ASN A 1 51  ? -26.43086 -25.36716 -10.01417 1.000 64.82766 ? 51  ASN A ND2  1 
ATOM   750  H H    . ASN A 1 51  ? -21.68227 -27.12404 -8.33749  1.000 39.95124 ? 51  ASN A H    1 
ATOM   751  H HA   . ASN A 1 51  ? -23.94381 -26.28630 -7.17842  1.000 44.81700 ? 51  ASN A HA   1 
ATOM   752  H HB2  . ASN A 1 51  ? -23.82401 -25.06742 -9.27776  1.000 53.42299 ? 51  ASN A HB2  1 
ATOM   753  H HB3  . ASN A 1 51  ? -24.11204 -26.46633 -9.97455  1.000 53.42299 ? 51  ASN A HB3  1 
ATOM   754  H HD21 . ASN A 1 51  ? -27.27853 -25.24135 -9.94191  1.000 77.84348 ? 51  ASN A HD21 1 
ATOM   755  H HD22 . ASN A 1 51  ? -26.04211 -25.25165 -10.77255 1.000 77.84348 ? 51  ASN A HD22 1 
ATOM   756  N N    . PRO A 1 52  ? -23.53326 -28.89864 -7.01370  1.000 33.43267 ? 52  PRO A N    1 
ATOM   757  C CA   . PRO A 1 52  ? -23.72129 -30.34893 -7.07504  1.000 30.36574 ? 52  PRO A CA   1 
ATOM   758  C C    . PRO A 1 52  ? -25.19549 -30.69554 -6.97371  1.000 30.66484 ? 52  PRO A C    1 
ATOM   759  O O    . PRO A 1 52  ? -25.96399 -30.01975 -6.28709  1.000 30.40262 ? 52  PRO A O    1 
ATOM   760  C CB   . PRO A 1 52  ? -22.92703 -30.86245 -5.86905  1.000 30.74310 ? 52  PRO A CB   1 
ATOM   761  C CG   . PRO A 1 52  ? -22.92301 -29.70147 -4.90121  1.000 29.58617 ? 52  PRO A CG   1 
ATOM   762  C CD   . PRO A 1 52  ? -22.93515 -28.45234 -5.74040  1.000 33.66733 ? 52  PRO A CD   1 
ATOM   763  H HA   . PRO A 1 52  ? -23.34629 -30.72623 -7.88617  1.000 36.48918 ? 52  PRO A HA   1 
ATOM   764  H HB2  . PRO A 1 52  ? -23.36836 -31.63613 -5.48494  1.000 36.94200 ? 52  PRO A HB2  1 
ATOM   765  H HB3  . PRO A 1 52  ? -22.02500 -31.09524 -6.13935  1.000 36.94200 ? 52  PRO A HB3  1 
ATOM   766  H HG2  . PRO A 1 52  ? -23.71254 -29.74357 -4.33927  1.000 35.55370 ? 52  PRO A HG2  1 
ATOM   767  H HG3  . PRO A 1 52  ? -22.12346 -29.73747 -4.35319  1.000 35.55370 ? 52  PRO A HG3  1 
ATOM   768  H HD2  . PRO A 1 52  ? -23.47964 -27.76454 -5.32645  1.000 40.45109 ? 52  PRO A HD2  1 
ATOM   769  H HD3  . PRO A 1 52  ? -22.03373 -28.12249 -5.88018  1.000 40.45109 ? 52  PRO A HD3  1 
ATOM   770  N N    . ASN A 1 53  ? -25.59957 -31.71947 -7.70976  1.000 26.78036 ? 53  ASN A N    1 
ATOM   771  C CA   . ASN A 1 53  ? -26.85786 -32.41205 -7.46432  1.000 27.23391 ? 53  ASN A CA   1 
ATOM   772  C C    . ASN A 1 53  ? -26.44937 -33.70935 -6.77436  1.000 27.88463 ? 53  ASN A C    1 
ATOM   773  O O    . ASN A 1 53  ? -26.05725 -34.67625 -7.44125  1.000 28.12624 ? 53  ASN A O    1 
ATOM   774  C CB   . ASN A 1 53  ? -27.64704 -32.64651 -8.74128  1.000 30.36192 ? 53  ASN A CB   1 
ATOM   775  C CG   . ASN A 1 53  ? -29.00592 -33.26567 -8.47557  1.000 28.83373 ? 53  ASN A CG   1 
ATOM   776  O OD1  . ASN A 1 53  ? -29.12819 -34.19215 -7.67344  1.000 32.80476 ? 53  ASN A OD1  1 
ATOM   777  N ND2  . ASN A 1 53  ? -30.03663 -32.74637 -9.13713  1.000 30.39640 ? 53  ASN A ND2  1 
ATOM   778  H H    . ASN A 1 53  ? -25.15338 -32.03939 -8.37171  1.000 32.18672 ? 53  ASN A H    1 
ATOM   779  H HA   . ASN A 1 53  ? -27.44140 -31.88874 -6.89290  1.000 32.73098 ? 53  ASN A HA   1 
ATOM   780  H HB2  . ASN A 1 53  ? -27.78511 -31.79746 -9.18956  1.000 36.48459 ? 53  ASN A HB2  1 
ATOM   781  H HB3  . ASN A 1 53  ? -27.14890 -33.24817 -9.31639  1.000 36.48459 ? 53  ASN A HB3  1 
ATOM   782  H HD21 . ASN A 1 53  ? -30.82711 -33.06409 -9.01962  1.000 36.52597 ? 53  ASN A HD21 1 
ATOM   783  H HD22 . ASN A 1 53  ? -29.91248 -32.09295 -9.68231  1.000 36.52597 ? 53  ASN A HD22 1 
ATOM   784  N N    . TYR A 1 54  ? -26.47926 -33.71067 -5.44362  1.000 28.52897 ? 54  TYR A N    1 
ATOM   785  C CA   . TYR A 1 54  ? -25.88261 -34.81715 -4.70917  1.000 29.31918 ? 54  TYR A CA   1 
ATOM   786  C C    . TYR A 1 54  ? -26.61536 -36.11975 -4.98098  1.000 29.92675 ? 54  TYR A C    1 
ATOM   787  O O    . TYR A 1 54  ? -25.98464 -37.17328 -5.13304  1.000 27.79883 ? 54  TYR A O    1 
ATOM   788  C CB   . TYR A 1 54  ? -25.85864 -34.51270 -3.21435  1.000 28.06685 ? 54  TYR A CB   1 
ATOM   789  C CG   . TYR A 1 54  ? -24.76128 -33.55570 -2.82318  1.000 23.69138 ? 54  TYR A CG   1 
ATOM   790  C CD1  . TYR A 1 54  ? -23.43995 -33.97138 -2.76327  1.000 24.07557 ? 54  TYR A CD1  1 
ATOM   791  C CD2  . TYR A 1 54  ? -25.04076 -32.23108 -2.52573  1.000 23.87586 ? 54  TYR A CD2  1 
ATOM   792  C CE1  . TYR A 1 54  ? -22.42913 -33.10131 -2.41201  1.000 23.61112 ? 54  TYR A CE1  1 
ATOM   793  C CE2  . TYR A 1 54  ? -24.03518 -31.35352 -2.16955  1.000 25.66054 ? 54  TYR A CE2  1 
ATOM   794  C CZ   . TYR A 1 54  ? -22.72791 -31.79028 -2.11852  1.000 24.03489 ? 54  TYR A CZ   1 
ATOM   795  O OH   . TYR A 1 54  ? -21.72091 -30.92085 -1.76340  1.000 23.07807 ? 54  TYR A OH   1 
ATOM   796  H H    . TYR A 1 54  ? -26.83092 -33.09677 -4.95470  1.000 34.28505 ? 54  TYR A H    1 
ATOM   797  H HA   . TYR A 1 54  ? -24.96440 -34.92310 -5.00340  1.000 35.23331 ? 54  TYR A HA   1 
ATOM   798  H HB2  . TYR A 1 54  ? -26.70633 -34.11516 -2.96084  1.000 33.73051 ? 54  TYR A HB2  1 
ATOM   799  H HB3  . TYR A 1 54  ? -25.72134 -35.34014 -2.72713  1.000 33.73051 ? 54  TYR A HB3  1 
ATOM   800  H HD1  . TYR A 1 54  ? -23.23096 -34.85507 -2.96406  1.000 28.94097 ? 54  TYR A HD1  1 
ATOM   801  H HD2  . TYR A 1 54  ? -25.91916 -31.92834 -2.56659  1.000 28.70132 ? 54  TYR A HD2  1 
ATOM   802  H HE1  . TYR A 1 54  ? -21.54902 -33.39936 -2.37362  1.000 28.38363 ? 54  TYR A HE1  1 
ATOM   803  H HE2  . TYR A 1 54  ? -24.23930 -30.46967 -1.96451  1.000 30.84294 ? 54  TYR A HE2  1 
ATOM   804  H HH   . TYR A 1 54  ? -22.04232 -30.16438 -1.59006  1.000 27.74397 ? 54  TYR A HH   1 
ATOM   805  N N    . GLU A 1 55  ? -27.94277 -36.08288 -5.06116  1.000 31.47521 ? 55  GLU A N    1 
ATOM   806  C CA   A GLU A 1 55  ? -28.68654 -37.30572 -5.33948  0.500 35.02042 ? 55  GLU A CA   1 
ATOM   807  C CA   B GLU A 1 55  ? -28.68571 -37.30976 -5.33987  0.500 35.03836 ? 55  GLU A CA   1 
ATOM   808  C C    . GLU A 1 55  ? -28.24587 -37.91561 -6.66774  1.000 32.32158 ? 55  GLU A C    1 
ATOM   809  O O    . GLU A 1 55  ? -27.98698 -39.11885 -6.76178  1.000 30.33267 ? 55  GLU A O    1 
ATOM   810  C CB   A GLU A 1 55  ? -30.18578 -37.01930 -5.32489  0.500 38.85599 ? 55  GLU A CB   1 
ATOM   811  C CB   B GLU A 1 55  ? -30.19086 -37.04892 -5.33651  0.500 39.18611 ? 55  GLU A CB   1 
ATOM   812  C CG   A GLU A 1 55  ? -30.75521 -36.71151 -3.93280  0.500 44.18353 ? 55  GLU A CG   1 
ATOM   813  C CG   B GLU A 1 55  ? -30.75935 -36.58267 -3.99900  0.500 44.19433 ? 55  GLU A CG   1 
ATOM   814  C CD   A GLU A 1 55  ? -30.41724 -35.31084 -3.41461  0.500 48.09172 ? 55  GLU A CD   1 
ATOM   815  C CD   B GLU A 1 55  ? -30.75086 -37.66245 -2.92549  0.500 49.09762 ? 55  GLU A CD   1 
ATOM   816  O OE1  A GLU A 1 55  ? -29.89446 -34.47869 -4.18832  0.500 39.37454 ? 55  GLU A OE1  1 
ATOM   817  O OE1  B GLU A 1 55  ? -30.51134 -38.84233 -3.25827  0.500 44.36944 ? 55  GLU A OE1  1 
ATOM   818  O OE2  A GLU A 1 55  ? -30.68588 -35.04172 -2.22179  0.500 46.39834 ? 55  GLU A OE2  1 
ATOM   819  O OE2  B GLU A 1 55  ? -30.98757 -37.32624 -1.74340  0.500 48.23350 ? 55  GLU A OE2  1 
ATOM   820  H H    . GLU A 1 55  ? -28.42845 -35.38023 -4.96115  1.000 37.82054 ? 55  GLU A H    1 
ATOM   821  H HA   . GLU A 1 55  ? -28.50883 -37.95619 -4.64219  1.000 42.09632 ? 55  GLU A HA   1 
ATOM   822  H HB2  A GLU A 1 55  ? -30.35997 -36.25069 -5.89039  0.500 46.67748 ? 55  GLU A HB2  1 
ATOM   823  H HB2  B GLU A 1 55  ? -30.38489 -36.36019 -5.99141  0.500 47.07362 ? 55  GLU A HB2  1 
ATOM   824  H HB3  A GLU A 1 55  ? -30.65317 -37.79672 -5.66849  0.500 46.67748 ? 55  GLU A HB3  1 
ATOM   825  H HB3  B GLU A 1 55  ? -30.64588 -37.87158 -5.57547  0.500 47.07362 ? 55  GLU A HB3  1 
ATOM   826  H HG2  A GLU A 1 55  ? -31.72162 -36.78668 -3.96862  0.500 53.07052 ? 55  GLU A HG2  1 
ATOM   827  H HG2  B GLU A 1 55  ? -30.22815 -35.83837 -3.67534  0.500 53.08349 ? 55  GLU A HG2  1 
ATOM   828  H HG3  A GLU A 1 55  ? -30.39569 -37.35365 -3.30089  0.500 53.07052 ? 55  GLU A HG3  1 
ATOM   829  H HG3  B GLU A 1 55  ? -31.67853 -36.30198 -4.13019  0.500 53.08349 ? 55  GLU A HG3  1 
ATOM   830  N N    . ASP A 1 56  ? -28.13867 -37.08534 -7.71475  1.000 30.46767 ? 56  ASP A N    1 
ATOM   831  C CA   . ASP A 1 56  ? -27.70792 -37.59593 -9.01567  1.000 31.46579 ? 56  ASP A CA   1 
ATOM   832  C C    . ASP A 1 56  ? -26.25693 -38.06628 -8.99016  1.000 29.53249 ? 56  ASP A C    1 
ATOM   833  O O    . ASP A 1 56  ? -25.92996 -39.10935 -9.56980  1.000 31.76075 ? 56  ASP A O    1 
ATOM   834  C CB   . ASP A 1 56  ? -27.88599 -36.52103 -10.08601 1.000 32.91464 ? 56  ASP A CB   1 
ATOM   835  C CG   . ASP A 1 56  ? -29.33272 -36.32994 -10.48213 1.000 33.23937 ? 56  ASP A CG   1 
ATOM   836  O OD1  . ASP A 1 56  ? -30.20436 -37.07890 -9.98707  1.000 33.01620 ? 56  ASP A OD1  1 
ATOM   837  O OD2  . ASP A 1 56  ? -29.59166 -35.42322 -11.29979 1.000 33.54881 ? 56  ASP A OD2  1 
ATOM   838  H H    . ASP A 1 56  ? -28.30623 -36.24203 -7.69576  1.000 36.61150 ? 56  ASP A H    1 
ATOM   839  H HA   . ASP A 1 56  ? -28.26711 -38.35589 -9.24076  1.000 37.80924 ? 56  ASP A HA   1 
ATOM   840  H HB2  . ASP A 1 56  ? -27.55358 -35.67607 -9.74475  1.000 39.54786 ? 56  ASP A HB2  1 
ATOM   841  H HB3  . ASP A 1 56  ? -27.38868 -36.77753 -10.87834 1.000 39.54786 ? 56  ASP A HB3  1 
ATOM   842  N N    . LEU A 1 57  ? -25.36642 -37.30786 -8.35214  1.000 29.10866 ? 57  LEU A N    1 
ATOM   843  C CA   . LEU A 1 57  ? -23.97372 -37.73807 -8.28564  1.000 29.48878 ? 57  LEU A CA   1 
ATOM   844  C C    . LEU A 1 57  ? -23.85637 -39.06040 -7.54878  1.000 28.31920 ? 57  LEU A C    1 
ATOM   845  O O    . LEU A 1 57  ? -23.09156 -39.94477 -7.95132  1.000 30.07136 ? 57  LEU A O    1 
ATOM   846  C CB   . LEU A 1 57  ? -23.12477 -36.68178 -7.59618  1.000 27.94927 ? 57  LEU A CB   1 
ATOM   847  C CG   . LEU A 1 57  ? -22.88158 -35.43025 -8.42757  1.000 31.62982 ? 57  LEU A CG   1 
ATOM   848  C CD1  . LEU A 1 57  ? -22.34893 -34.34516 -7.52095  1.000 31.85257 ? 57  LEU A CD1  1 
ATOM   849  C CD2  . LEU A 1 57  ? -21.90954 -35.74006 -9.53850  1.000 34.94526 ? 57  LEU A CD2  1 
ATOM   850  H H    . LEU A 1 57  ? -25.53820 -36.56153 -7.96088  1.000 34.98068 ? 57  LEU A H    1 
ATOM   851  H HA   . LEU A 1 57  ? -23.63836 -37.84981 -9.18894  1.000 35.43683 ? 57  LEU A HA   1 
ATOM   852  H HB2  . LEU A 1 57  ? -23.57275 -36.41016 -6.77983  1.000 33.58942 ? 57  LEU A HB2  1 
ATOM   853  H HB3  . LEU A 1 57  ? -22.26016 -37.06867 -7.38719  1.000 33.58942 ? 57  LEU A HB3  1 
ATOM   854  H HG   . LEU A 1 57  ? -23.70381 -35.11743 -8.83620  1.000 38.00608 ? 57  LEU A HG   1 
ATOM   855  H HD11 . LEU A 1 57  ? -23.05211 -34.06832 -6.91284  1.000 38.27337 ? 57  LEU A HD11 1 
ATOM   856  H HD12 . LEU A 1 57  ? -21.59600 -34.69443 -7.01894  1.000 38.27337 ? 57  LEU A HD12 1 
ATOM   857  H HD13 . LEU A 1 57  ? -22.06470 -33.59235 -8.06262  1.000 38.27337 ? 57  LEU A HD13 1 
ATOM   858  H HD21 . LEU A 1 57  ? -21.64074 -34.91054 -9.96339  1.000 41.98460 ? 57  LEU A HD21 1 
ATOM   859  H HD22 . LEU A 1 57  ? -21.13397 -36.18644 -9.16417  1.000 41.98460 ? 57  LEU A HD22 1 
ATOM   860  H HD23 . LEU A 1 57  ? -22.34337 -36.31780 -10.18573 1.000 41.98460 ? 57  LEU A HD23 1 
ATOM   861  N N    . LEU A 1 58  ? -24.62724 -39.21586 -6.47309  1.000 28.19814 ? 58  LEU A N    1 
ATOM   862  C CA   . LEU A 1 58  ? -24.48441 -40.38042 -5.61095  1.000 26.64813 ? 58  LEU A CA   1 
ATOM   863  C C    . LEU A 1 58  ? -24.96221 -41.64451 -6.30131  1.000 28.02108 ? 58  LEU A C    1 
ATOM   864  O O    . LEU A 1 58  ? -24.49224 -42.74291 -5.98188  1.000 27.42696 ? 58  LEU A O    1 
ATOM   865  C CB   . LEU A 1 58  ? -25.25867 -40.15734 -4.31227  1.000 25.31218 ? 58  LEU A CB   1 
ATOM   866  C CG   . LEU A 1 58  ? -25.11379 -41.24251 -3.24672  1.000 24.63949 ? 58  LEU A CG   1 
ATOM   867  C CD1  . LEU A 1 58  ? -23.64246 -41.42940 -2.92448  1.000 25.10285 ? 58  LEU A CD1  1 
ATOM   868  C CD2  . LEU A 1 58  ? -25.89625 -40.92045 -1.98006  1.000 26.25338 ? 58  LEU A CD2  1 
ATOM   869  H H    . LEU A 1 58  ? -25.23695 -38.66324 -6.22319  1.000 33.88806 ? 58  LEU A H    1 
ATOM   870  H HA   . LEU A 1 58  ? -23.54773 -40.49837 -5.38819  1.000 32.02804 ? 58  LEU A HA   1 
ATOM   871  H HB2  . LEU A 1 58  ? -24.95280 -39.32570 -3.91766  1.000 30.42491 ? 58  LEU A HB2  1 
ATOM   872  H HB3  . LEU A 1 58  ? -26.20173 -40.09399 -4.53029  1.000 30.42491 ? 58  LEU A HB3  1 
ATOM   873  H HG   . LEU A 1 58  ? -25.48305 -42.06920 -3.59477  1.000 29.61768 ? 58  LEU A HG   1 
ATOM   874  H HD11 . LEU A 1 58  ? -23.24889 -42.02612 -3.58016  1.000 30.17371 ? 58  LEU A HD11 1 
ATOM   875  H HD12 . LEU A 1 58  ? -23.20039 -40.56653 -2.95506  1.000 30.17371 ? 58  LEU A HD12 1 
ATOM   876  H HD13 . LEU A 1 58  ? -23.55967 -41.81221 -2.03706  1.000 30.17371 ? 58  LEU A HD13 1 
ATOM   877  H HD21 . LEU A 1 58  ? -25.89967 -41.70085 -1.40397  1.000 31.55435 ? 58  LEU A HD21 1 
ATOM   878  H HD22 . LEU A 1 58  ? -25.47040 -40.17630 -1.52642  1.000 31.55435 ? 58  LEU A HD22 1 
ATOM   879  H HD23 . LEU A 1 58  ? -26.80532 -40.68391 -2.22198  1.000 31.55435 ? 58  LEU A HD23 1 
ATOM   880  N N    . ILE A 1 59  ? -25.88841 -41.51264 -7.24544  1.000 31.30596 ? 59  ILE A N    1 
ATOM   881  C CA   . ILE A 1 59  ? -26.45107 -42.68349 -7.90518  1.000 31.24480 ? 59  ILE A CA   1 
ATOM   882  C C    . ILE A 1 59  ? -25.41379 -43.37652 -8.76527  1.000 32.35961 ? 59  ILE A C    1 
ATOM   883  O O    . ILE A 1 59  ? -25.50627 -44.58666 -9.01058  1.000 33.82626 ? 59  ILE A O    1 
ATOM   884  C CB   . ILE A 1 59  ? -27.68937 -42.24398 -8.70853  1.000 32.82210 ? 59  ILE A CB   1 
ATOM   885  C CG1  . ILE A 1 59  ? -28.82637 -41.98019 -7.71825  1.000 33.53266 ? 59  ILE A CG1  1 
ATOM   886  C CG2  . ILE A 1 59  ? -28.02078 -43.26391 -9.77263  1.000 43.18406 ? 59  ILE A CG2  1 
ATOM   887  C CD1  . ILE A 1 59  ? -30.01803 -41.28058 -8.30208  1.000 40.94857 ? 59  ILE A CD1  1 
ATOM   888  H H    . ILE A 1 59  ? -26.20598 -40.76227 -7.52057  1.000 37.61744 ? 59  ILE A H    1 
ATOM   889  H HA   . ILE A 1 59  ? -26.72877 -43.33346 -7.24087  1.000 37.54405 ? 59  ILE A HA   1 
ATOM   890  H HB   . ILE A 1 59  ? -27.52171 -41.41977 -9.19172  1.000 39.43681 ? 59  ILE A HB   1 
ATOM   891  H HG12 . ILE A 1 59  ? -29.13121 -42.83081 -7.36554  1.000 40.28948 ? 59  ILE A HG12 1 
ATOM   892  H HG13 . ILE A 1 59  ? -28.48588 -41.42563 -6.99892  1.000 40.28948 ? 59  ILE A HG13 1 
ATOM   893  H HG21 . ILE A 1 59  ? -27.38316 -43.18114 -10.49891 1.000 51.87116 ? 59  ILE A HG21 1 
ATOM   894  H HG22 . ILE A 1 59  ? -27.96840 -44.15201 -9.38607  1.000 51.87116 ? 59  ILE A HG22 1 
ATOM   895  H HG23 . ILE A 1 59  ? -28.91863 -43.09817 -10.10021 1.000 51.87116 ? 59  ILE A HG23 1 
ATOM   896  H HD11 . ILE A 1 59  ? -29.83230 -40.32992 -8.35343  1.000 49.18858 ? 59  ILE A HD11 1 
ATOM   897  H HD12 . ILE A 1 59  ? -30.18752 -41.63293 -9.18979  1.000 49.18858 ? 59  ILE A HD12 1 
ATOM   898  H HD13 . ILE A 1 59  ? -30.78688 -41.43707 -7.73174  1.000 49.18858 ? 59  ILE A HD13 1 
ATOM   899  N N    . ARG A 1 60  ? -24.41693 -42.64229 -9.23311  1.000 31.69253 ? 60  ARG A N    1 
ATOM   900  C CA   . ARG A 1 60  ? -23.34003 -43.23558 -10.01189 1.000 30.89754 ? 60  ARG A CA   1 
ATOM   901  C C    . ARG A 1 60  ? -22.30063 -43.93514 -9.14313  1.000 31.73205 ? 60  ARG A C    1 
ATOM   902  O O    . ARG A 1 60  ? -21.34725 -44.49910 -9.68982  1.000 30.69531 ? 60  ARG A O    1 
ATOM   903  C CB   . ARG A 1 60  ? -22.67724 -42.15168 -10.86857 1.000 33.54756 ? 60  ARG A CB   1 
ATOM   904  H H    . ARG A 1 60  ? -24.34002 -41.79418 -9.11315  1.000 38.08133 ? 60  ARG A H    1 
ATOM   905  H HA   . ARG A 1 60  ? -23.70683 -43.90400 -10.61153 1.000 37.12734 ? 60  ARG A HA   1 
ATOM   906  N N    . LYS A 1 61  ? -22.45794 -43.92830 -7.81906  1.000 30.70906 ? 61  LYS A N    1 
ATOM   907  C CA   . LYS A 1 61  ? -21.47309 -44.50091 -6.91079  1.000 29.42208 ? 61  LYS A CA   1 
ATOM   908  C C    . LYS A 1 61  ? -21.98307 -45.79979 -6.30057  1.000 28.14195 ? 61  LYS A C    1 
ATOM   909  O O    . LYS A 1 61  ? -23.14638 -45.89969 -5.90080  1.000 28.62968 ? 61  LYS A O    1 
ATOM   910  C CB   . LYS A 1 61  ? -21.11940 -43.51815 -5.78707  1.000 28.15563 ? 61  LYS A CB   1 
ATOM   911  C CG   . LYS A 1 61  ? -20.58881 -42.18534 -6.26940  1.000 27.51541 ? 61  LYS A CG   1 
ATOM   912  C CD   . LYS A 1 61  ? -19.30519 -42.34391 -7.05001  1.000 30.55216 ? 61  LYS A CD   1 
ATOM   913  C CE   . LYS A 1 61  ? -18.75517 -40.98569 -7.43136  1.000 30.57444 ? 61  LYS A CE   1 
ATOM   914  N NZ   . LYS A 1 61  ? -17.43768 -41.06548 -8.12707  1.000 35.12728 ? 61  LYS A NZ   1 
ATOM   915  H H    . LYS A 1 61  ? -23.14053 -43.59070 -7.41943  1.000 36.90116 ? 61  LYS A H    1 
ATOM   916  H HA   . LYS A 1 61  ? -20.67071 -44.70328 -7.41689  1.000 35.35678 ? 61  LYS A HA   1 
ATOM   917  H HB2  . LYS A 1 61  ? -21.91802 -43.34477 -5.26454  1.000 33.83705 ? 61  LYS A HB2  1 
ATOM   918  H HB3  . LYS A 1 61  ? -20.43735 -43.92062 -5.22696  1.000 33.83705 ? 61  LYS A HB3  1 
ATOM   919  H HG2  . LYS A 1 61  ? -21.24676 -41.76885 -6.84779  1.000 33.06878 ? 61  LYS A HG2  1 
ATOM   920  H HG3  . LYS A 1 61  ? -20.41111 -41.61550 -5.50481  1.000 33.06878 ? 61  LYS A HG3  1 
ATOM   921  H HD2  . LYS A 1 61  ? -18.64695 -42.80381 -6.50585  1.000 36.71289 ? 61  LYS A HD2  1 
ATOM   922  H HD3  . LYS A 1 61  ? -19.47636 -42.84833 -7.86067  1.000 36.71289 ? 61  LYS A HD3  1 
ATOM   923  H HE2  . LYS A 1 61  ? -19.38209 -40.54760 -8.02797  1.000 36.73962 ? 61  LYS A HE2  1 
ATOM   924  H HE3  . LYS A 1 61  ? -18.63693 -40.45610 -6.62734  1.000 36.73962 ? 61  LYS A HE3  1 
ATOM   925  H HZ1  . LYS A 1 61  ? -17.10231 -40.24865 -8.23847  1.000 42.20302 ? 61  LYS A HZ1  1 
ATOM   926  H HZ2  . LYS A 1 61  ? -16.86717 -41.54856 -7.64410  1.000 42.20302 ? 61  LYS A HZ2  1 
ATOM   927  H HZ3  . LYS A 1 61  ? -17.53719 -41.44807 -8.92446  1.000 42.20302 ? 61  LYS A HZ3  1 
ATOM   928  N N    . SER A 1 62  ? -21.10222 -46.78930 -6.23007  1.000 25.90750 ? 62  SER A N    1 
ATOM   929  C CA   . SER A 1 62  ? -21.38431 -48.05642 -5.57200  1.000 26.29061 ? 62  SER A CA   1 
ATOM   930  C C    . SER A 1 62  ? -20.43690 -48.21273 -4.38872  1.000 26.00632 ? 62  SER A C    1 
ATOM   931  O O    . SER A 1 62  ? -19.50510 -47.42626 -4.20288  1.000 25.72934 ? 62  SER A O    1 
ATOM   932  C CB   . SER A 1 62  ? -21.24015 -49.22661 -6.55184  1.000 28.91319 ? 62  SER A CB   1 
ATOM   933  O OG   . SER A 1 62  ? -22.08580 -49.05373 -7.67645  1.000 32.95266 ? 62  SER A OG   1 
ATOM   934  H H    . SER A 1 62  ? -20.31162 -46.74828 -6.56604  1.000 31.13929 ? 62  SER A H    1 
ATOM   935  H HA   . SER A 1 62  ? -22.29535 -48.06804 -5.23917  1.000 31.59903 ? 62  SER A HA   1 
ATOM   936  H HB2  . SER A 1 62  ? -20.31955 -49.27331 -6.85386  1.000 34.74612 ? 62  SER A HB2  1 
ATOM   937  H HB3  . SER A 1 62  ? -21.48271 -50.04912 -6.09848  1.000 34.74612 ? 62  SER A HB3  1 
ATOM   938  H HG   . SER A 1 62  ? -21.69366 -49.31156 -8.37312  1.000 39.59348 ? 62  SER A HG   1 
ATOM   939  N N    . ASN A 1 63  ? -20.68793 -49.24953 -3.58082  1.000 25.37074 ? 63  ASN A N    1 
ATOM   940  C CA   . ASN A 1 63  ? -19.88493 -49.47460 -2.38249  1.000 24.48104 ? 63  ASN A CA   1 
ATOM   941  C C    . ASN A 1 63  ? -18.39152 -49.50719 -2.69900  1.000 25.37730 ? 63  ASN A C    1 
ATOM   942  O O    . ASN A 1 63  ? -17.58019 -48.93085 -1.96527  1.000 24.17244 ? 63  ASN A O    1 
ATOM   943  C CB   . ASN A 1 63  ? -20.29435 -50.78568 -1.70010  1.000 26.15959 ? 63  ASN A CB   1 
ATOM   944  C CG   . ASN A 1 63  ? -21.69506 -50.73442 -1.09496  1.000 25.80620 ? 63  ASN A CG   1 
ATOM   945  O OD1  . ASN A 1 63  ? -22.17356 -49.67679 -0.67720  1.000 23.87513 ? 63  ASN A OD1  1 
ATOM   946  N ND2  . ASN A 1 63  ? -22.34744 -51.89167 -1.02772  1.000 25.23518 ? 63  ASN A ND2  1 
ATOM   947  H H    . ASN A 1 63  ? -21.31105 -49.82905 -3.70520  1.000 30.49518 ? 63  ASN A H    1 
ATOM   948  H HA   . ASN A 1 63  ? -20.05386 -48.74204 -1.76953  1.000 29.42753 ? 63  ASN A HA   1 
ATOM   949  H HB2  . ASN A 1 63  ? -20.27861 -51.50014 -2.35600  1.000 31.44180 ? 63  ASN A HB2  1 
ATOM   950  H HB3  . ASN A 1 63  ? -19.66732 -50.97763 -0.98533  1.000 31.44180 ? 63  ASN A HB3  1 
ATOM   951  H HD21 . ASN A 1 63  ? -23.14022 -51.91971 -0.69558  1.000 30.33251 ? 63  ASN A HD21 1 
ATOM   952  H HD22 . ASN A 1 63  ? -21.97645 -52.61184 -1.31638  1.000 30.33251 ? 63  ASN A HD22 1 
ATOM   953  N N    . HIS A 1 64  ? -18.00202 -50.20054 -3.77406  1.000 26.18793 ? 64  HIS A N    1 
ATOM   954  C CA   . HIS A 1 64  ? -16.58229 -50.35773 -4.06643  1.000 26.74486 ? 64  HIS A CA   1 
ATOM   955  C C    . HIS A 1 64  ? -15.93257 -49.06702 -4.55315  1.000 25.79407 ? 64  HIS A C    1 
ATOM   956  O O    . HIS A 1 64  ? -14.70255 -49.02200 -4.66728  1.000 26.48938 ? 64  HIS A O    1 
ATOM   957  C CB   . HIS A 1 64  ? -16.36588 -51.48134 -5.09062  1.000 28.52867 ? 64  HIS A CB   1 
ATOM   958  C CG   . HIS A 1 64  ? -16.89758 -51.17525 -6.45664  1.000 28.41619 ? 64  HIS A CG   1 
ATOM   959  N ND1  . HIS A 1 64  ? -18.13036 -51.61140 -6.89189  1.000 29.52448 ? 64  HIS A ND1  1 
ATOM   960  C CD2  . HIS A 1 64  ? -16.35669 -50.48348 -7.48806  1.000 30.62666 ? 64  HIS A CD2  1 
ATOM   961  C CE1  . HIS A 1 64  ? -18.33136 -51.19329 -8.12902  1.000 34.37791 ? 64  HIS A CE1  1 
ATOM   962  N NE2  . HIS A 1 64  ? -17.26945 -50.50809 -8.51471  1.000 32.35865 ? 64  HIS A NE2  1 
ATOM   963  H H    . HIS A 1 64  ? -18.53200 -50.57991 -4.33512  1.000 31.47580 ? 64  HIS A H    1 
ATOM   964  H HA   . HIS A 1 64  ? -16.12911 -50.62259 -3.25072  1.000 32.14413 ? 64  HIS A HA   1 
ATOM   965  H HB2  . HIS A 1 64  ? -15.41355 -51.64511 -5.17520  1.000 34.28469 ? 64  HIS A HB2  1 
ATOM   966  H HB3  . HIS A 1 64  ? -16.81315 -52.28131 -4.77298  1.000 34.28469 ? 64  HIS A HB3  1 
ATOM   967  H HD2  . HIS A 1 64  ? -15.52393 -50.06961 -7.49917  1.000 36.80228 ? 64  HIS A HD2  1 
ATOM   968  H HE1  . HIS A 1 64  ? -19.09088 -51.35390 -8.64112  1.000 41.30379 ? 64  HIS A HE1  1 
ATOM   969  H HE2  . HIS A 1 64  ? -17.16630 -50.13751 -9.28388  1.000 38.88067 ? 64  HIS A HE2  1 
ATOM   970  N N    . ASN A 1 65  ? -16.71674 -48.02011 -4.83521  1.000 25.30839 ? 65  ASN A N    1 
ATOM   971  C CA   . ASN A 1 65  ? -16.14811 -46.73295 -5.20689  1.000 27.38129 ? 65  ASN A CA   1 
ATOM   972  C C    . ASN A 1 65  ? -15.68998 -45.92524 -4.00407  1.000 25.09586 ? 65  ASN A C    1 
ATOM   973  O O    . ASN A 1 65  ? -15.00581 -44.91230 -4.18088  1.000 26.03310 ? 65  ASN A O    1 
ATOM   974  C CB   . ASN A 1 65  ? -17.15275 -45.88918 -5.99469  1.000 25.78207 ? 65  ASN A CB   1 
ATOM   975  C CG   . ASN A 1 65  ? -17.52779 -46.51679 -7.31480  1.000 32.90402 ? 65  ASN A CG   1 
ATOM   976  O OD1  . ASN A 1 65  ? -18.70864 -46.61582 -7.65213  1.000 29.10758 ? 65  ASN A OD1  1 
ATOM   977  N ND2  . ASN A 1 65  ? -16.52531 -46.94125 -8.07739  1.000 32.16096 ? 65  ASN A ND2  1 
ATOM   978  H H    . ASN A 1 65  ? -17.57640 -48.03580 -4.81682  1.000 30.42036 ? 65  ASN A H    1 
ATOM   979  H HA   . ASN A 1 65  ? -15.38791 -46.90651 -5.78384  1.000 32.90784 ? 65  ASN A HA   1 
ATOM   980  H HB2  . ASN A 1 65  ? -17.96187 -45.78769 -5.46941  1.000 30.98877 ? 65  ASN A HB2  1 
ATOM   981  H HB3  . ASN A 1 65  ? -16.76313 -45.01941 -6.17523  1.000 30.98877 ? 65  ASN A HB3  1 
ATOM   982  H HD21 . ASN A 1 65  ? -16.68885 -47.30596 -8.83886  1.000 38.64345 ? 65  ASN A HD21 1 
ATOM   983  H HD22 . ASN A 1 65  ? -15.71313 -46.85118 -7.80932  1.000 38.64345 ? 65  ASN A HD22 1 
ATOM   984  N N    . PHE A 1 66  ? -16.04495 -46.33500 -2.79654  1.000 23.66620 ? 66  PHE A N    1 
ATOM   985  C CA   . PHE A 1 66  ? -15.60278 -45.65885 -1.58641  1.000 23.96962 ? 66  PHE A CA   1 
ATOM   986  C C    . PHE A 1 66  ? -14.43404 -46.43091 -0.99448  1.000 25.86827 ? 66  PHE A C    1 
ATOM   987  O O    . PHE A 1 66  ? -14.61403 -47.52596 -0.45324  1.000 27.52465 ? 66  PHE A O    1 
ATOM   988  C CB   . PHE A 1 66  ? -16.74732 -45.55297 -0.59051  1.000 23.97401 ? 66  PHE A CB   1 
ATOM   989  C CG   . PHE A 1 66  ? -17.87707 -44.70260 -1.06438  1.000 23.03970 ? 66  PHE A CG   1 
ATOM   990  C CD1  . PHE A 1 66  ? -17.78806 -43.32674 -0.99432  1.000 25.42150 ? 66  PHE A CD1  1 
ATOM   991  C CD2  . PHE A 1 66  ? -19.02982 -45.27095 -1.57483  1.000 24.04419 ? 66  PHE A CD2  1 
ATOM   992  C CE1  . PHE A 1 66  ? -18.82028 -42.52807 -1.41834  1.000 26.49696 ? 66  PHE A CE1  1 
ATOM   993  C CE2  . PHE A 1 66  ? -20.06819 -44.47174 -2.00355  1.000 24.63898 ? 66  PHE A CE2  1 
ATOM   994  C CZ   . PHE A 1 66  ? -19.96274 -43.09545 -1.91527  1.000 25.32154 ? 66  PHE A CZ   1 
ATOM   995  H H    . PHE A 1 66  ? -16.55066 -47.01481 -2.64916  1.000 28.44973 ? 66  PHE A H    1 
ATOM   996  H HA   . PHE A 1 66  ? -15.29646 -44.76546 -1.80759  1.000 28.81383 ? 66  PHE A HA   1 
ATOM   997  H HB2  . PHE A 1 66  ? -17.09647 -46.44185 -0.42057  1.000 28.81910 ? 66  PHE A HB2  1 
ATOM   998  H HB3  . PHE A 1 66  ? -16.41011 -45.16603 0.23258   1.000 28.81910 ? 66  PHE A HB3  1 
ATOM   999  H HD1  . PHE A 1 66  ? -17.01621 -42.93487 -0.65433  1.000 30.55609 ? 66  PHE A HD1  1 
ATOM   1000 H HD2  . PHE A 1 66  ? -19.10493 -46.19632 -1.62914  1.000 28.90332 ? 66  PHE A HD2  1 
ATOM   1001 H HE1  . PHE A 1 66  ? -18.74380 -41.60258 -1.36817  1.000 31.84664 ? 66  PHE A HE1  1 
ATOM   1002 H HE2  . PHE A 1 66  ? -20.83918 -44.85784 -2.35196  1.000 29.61706 ? 66  PHE A HE2  1 
ATOM   1003 H HZ   . PHE A 1 66  ? -20.66739 -42.55594 -2.19327  1.000 30.43613 ? 66  PHE A HZ   1 
ATOM   1004 N N    . LEU A 1 67  ? -13.24240 -45.86443 -1.09379  1.000 25.87723 ? 67  LEU A N    1 
ATOM   1005 C CA   . LEU A 1 67  ? -12.06038 -46.47137 -0.50012  1.000 26.82476 ? 67  LEU A CA   1 
ATOM   1006 C C    . LEU A 1 67  ? -11.87757 -45.91858 0.90172   1.000 25.43122 ? 67  LEU A C    1 
ATOM   1007 O O    . LEU A 1 67  ? -11.69325 -44.70851 1.08212   1.000 24.97204 ? 67  LEU A O    1 
ATOM   1008 C CB   . LEU A 1 67  ? -10.82939 -46.19860 -1.35112  1.000 26.97505 ? 67  LEU A CB   1 
ATOM   1009 C CG   . LEU A 1 67  ? -10.93417 -46.73400 -2.77601  1.000 39.27889 ? 67  LEU A CG   1 
ATOM   1010 C CD1  . LEU A 1 67  ? -9.79635  -46.18623 -3.62597  1.000 41.60744 ? 67  LEU A CD1  1 
ATOM   1011 C CD2  . LEU A 1 67  ? -10.93906 -48.25535 -2.76140  1.000 43.44224 ? 67  LEU A CD2  1 
ATOM   1012 H H    . LEU A 1 67  ? -13.09040 -45.12323 -1.50259  1.000 31.10297 ? 67  LEU A H    1 
ATOM   1013 H HA   . LEU A 1 67  ? -12.17967 -47.43234 -0.44359  1.000 32.24000 ? 67  LEU A HA   1 
ATOM   1014 H HB2  . LEU A 1 67  ? -10.69425 -45.23951 -1.40395  1.000 32.42035 ? 67  LEU A HB2  1 
ATOM   1015 H HB3  . LEU A 1 67  ? -10.06231 -46.61914 -0.93203  1.000 32.42035 ? 67  LEU A HB3  1 
ATOM   1016 H HG   . LEU A 1 67  ? -11.76641 -46.44185 -3.17967  1.000 47.18496 ? 67  LEU A HG   1 
ATOM   1017 H HD11 . LEU A 1 67  ? -9.88120  -46.53229 -4.52816  1.000 49.97921 ? 67  LEU A HD11 1 
ATOM   1018 H HD12 . LEU A 1 67  ? -9.84833  -45.21769 -3.63695  1.000 49.97921 ? 67  LEU A HD12 1 
ATOM   1019 H HD13 . LEU A 1 67  ? -8.95134  -46.46780 -3.24180  1.000 49.97921 ? 67  LEU A HD13 1 
ATOM   1020 H HD21 . LEU A 1 67  ? -11.82985 -48.56614 -2.53598  1.000 52.18097 ? 67  LEU A HD21 1 
ATOM   1021 H HD22 . LEU A 1 67  ? -10.68782 -48.58042 -3.64010  1.000 52.18097 ? 67  LEU A HD22 1 
ATOM   1022 H HD23 . LEU A 1 67  ? -10.30257 -48.56685 -2.09902  1.000 52.18097 ? 67  LEU A HD23 1 
ATOM   1023 N N    . VAL A 1 68  ? -11.91141 -46.80670 1.88823   1.000 25.61539 ? 68  VAL A N    1 
ATOM   1024 C CA   . VAL A 1 68  ? -11.80812 -46.43556 3.29221   1.000 24.74940 ? 68  VAL A CA   1 
ATOM   1025 C C    . VAL A 1 68  ? -10.59791 -47.15042 3.86653   1.000 29.53342 ? 68  VAL A C    1 
ATOM   1026 O O    . VAL A 1 68  ? -10.51211 -48.38313 3.81216   1.000 29.80484 ? 68  VAL A O    1 
ATOM   1027 C CB   . VAL A 1 68  ? -13.08108 -46.79886 4.06921   1.000 24.26714 ? 68  VAL A CB   1 
ATOM   1028 C CG1  . VAL A 1 68  ? -12.97355 -46.31349 5.50565   1.000 23.64375 ? 68  VAL A CG1  1 
ATOM   1029 C CG2  . VAL A 1 68  ? -14.29699 -46.22236 3.37484   1.000 25.02820 ? 68  VAL A CG2  1 
ATOM   1030 H H    . VAL A 1 68  ? -11.99592 -47.65354 1.76441   1.000 30.78875 ? 68  VAL A H    1 
ATOM   1031 H HA   . VAL A 1 68  ? -11.66663 -45.47898 3.36858   1.000 29.74957 ? 68  VAL A HA   1 
ATOM   1032 H HB   . VAL A 1 68  ? -13.18661 -47.76281 4.09305   1.000 29.17086 ? 68  VAL A HB   1 
ATOM   1033 H HG11 . VAL A 1 68  ? -12.07788 -45.97366 5.65795   1.000 28.42279 ? 68  VAL A HG11 1 
ATOM   1034 H HG12 . VAL A 1 68  ? -13.62387 -45.60846 5.65028   1.000 28.42279 ? 68  VAL A HG12 1 
ATOM   1035 H HG13 . VAL A 1 68  ? -13.15187 -47.05582 6.10402   1.000 28.42279 ? 68  VAL A HG13 1 
ATOM   1036 H HG21 . VAL A 1 68  ? -15.09335 -46.48567 3.86206   1.000 30.08412 ? 68  VAL A HG21 1 
ATOM   1037 H HG22 . VAL A 1 68  ? -14.22311 -45.25530 3.35968   1.000 30.08412 ? 68  VAL A HG22 1 
ATOM   1038 H HG23 . VAL A 1 68  ? -14.33526 -46.56543 2.46834   1.000 30.08412 ? 68  VAL A HG23 1 
ATOM   1039 N N    . GLN A 1 69  ? -9.67850  -46.37755 4.43184   1.000 28.43098 ? 69  GLN A N    1 
ATOM   1040 C CA   . GLN A 1 69  ? -8.43990  -46.89709 4.98082   1.000 33.50844 ? 69  GLN A CA   1 
ATOM   1041 C C    . GLN A 1 69  ? -8.30363  -46.45642 6.42771   1.000 31.93784 ? 69  GLN A C    1 
ATOM   1042 O O    . GLN A 1 69  ? -8.40006  -45.26354 6.72879   1.000 27.48617 ? 69  GLN A O    1 
ATOM   1043 C CB   . GLN A 1 69  ? -7.25042  -46.39650 4.17008   1.000 37.26044 ? 69  GLN A CB   1 
ATOM   1044 C CG   . GLN A 1 69  ? -6.12184  -47.36241 4.03593   1.000 48.19027 ? 69  GLN A CG   1 
ATOM   1045 C CD   . GLN A 1 69  ? -5.01637  -46.78230 3.19426   1.000 49.57153 ? 69  GLN A CD   1 
ATOM   1046 O OE1  . GLN A 1 69  ? -5.25472  -46.28476 2.09236   1.000 43.37889 ? 69  GLN A OE1  1 
ATOM   1047 N NE2  . GLN A 1 69  ? -3.80106  -46.81299 3.71721   1.000 61.02216 ? 69  GLN A NE2  1 
ATOM   1048 H H    . GLN A 1 69  ? -9.75467  -45.52449 4.50993   1.000 34.16747 ? 69  GLN A H    1 
ATOM   1049 H HA   . GLN A 1 69  ? -8.45370  -47.86681 4.96248   1.000 40.26042 ? 69  GLN A HA   1 
ATOM   1050 H HB2  . GLN A 1 69  ? -7.55776  -46.18350 3.27506   1.000 44.76282 ? 69  GLN A HB2  1 
ATOM   1051 H HB3  . GLN A 1 69  ? -6.90087  -45.59988 4.59918   1.000 44.76282 ? 69  GLN A HB3  1 
ATOM   1052 H HG2  . GLN A 1 69  ? -5.76503  -47.56676 4.91447   1.000 57.87861 ? 69  GLN A HG2  1 
ATOM   1053 H HG3  . GLN A 1 69  ? -6.43967  -48.17385 3.60997   1.000 57.87861 ? 69  GLN A HG3  1 
ATOM   1054 H HE21 . GLN A 1 69  ? -3.67730  -47.15184 4.49789   1.000 73.27688 ? 69  GLN A HE21 1 
ATOM   1055 H HE22 . GLN A 1 69  ? -3.13506  -46.49407 3.27637   1.000 73.27688 ? 69  GLN A HE22 1 
ATOM   1056 N N    . ALA A 1 70  ? -8.07918  -47.42078 7.31416   1.000 32.89525 ? 70  ALA A N    1 
ATOM   1057 C CA   . ALA A 1 70  ? -7.78588  -47.17375 8.72251   1.000 34.26546 ? 70  ALA A CA   1 
ATOM   1058 C C    . ALA A 1 70  ? -6.30221  -47.44402 8.92558   1.000 42.21530 ? 70  ALA A C    1 
ATOM   1059 O O    . ALA A 1 70  ? -5.87185  -48.60267 8.90753   1.000 44.43874 ? 70  ALA A O    1 
ATOM   1060 C CB   . ALA A 1 70  ? -8.63892  -48.06145 9.62111   1.000 35.74229 ? 70  ALA A CB   1 
ATOM   1061 H H    . ALA A 1 70  ? -8.09188  -48.25758 7.11616   1.000 39.52458 ? 70  ALA A H    1 
ATOM   1062 H HA   . ALA A 1 70  ? -7.97651  -46.24990 8.94850   1.000 41.16884 ? 70  ALA A HA   1 
ATOM   1063 H HB1  . ALA A 1 70  ? -8.35415  -48.98284 9.51689   1.000 42.94104 ? 70  ALA A HB1  1 
ATOM   1064 H HB2  . ALA A 1 70  ? -8.52343  -47.78177 10.54270  1.000 42.94104 ? 70  ALA A HB2  1 
ATOM   1065 H HB3  . ALA A 1 70  ? -9.56941  -47.97154 9.36227   1.000 42.94104 ? 70  ALA A HB3  1 
ATOM   1066 N N    . GLY A 1 71  ? -5.52252  -46.38965 9.11957   1.000 39.13894 ? 71  GLY A N    1 
ATOM   1067 C CA   . GLY A 1 71  ? -4.08453  -46.56341 9.02555   1.000 41.52525 ? 71  GLY A CA   1 
ATOM   1068 C C    . GLY A 1 71  ? -3.74901  -47.16800 7.67524   1.000 43.56962 ? 71  GLY A C    1 
ATOM   1069 O O    . GLY A 1 71  ? -4.18925  -46.68371 6.62737   1.000 46.50675 ? 71  GLY A O    1 
ATOM   1070 H H    . GLY A 1 71  ? -5.79114  -45.59288 9.30014   1.000 47.01701 ? 71  GLY A H    1 
ATOM   1071 H HA2  . GLY A 1 71  ? -3.63742  -45.70701 9.11256   1.000 49.88059 ? 71  GLY A HA2  1 
ATOM   1072 H HA3  . GLY A 1 71  ? -3.77224  -47.15547 9.72759   1.000 49.88059 ? 71  GLY A HA3  1 
ATOM   1073 N N    . ASN A 1 72  ? -2.98112  -48.25339 7.69097   1.000 49.83436 ? 72  ASN A N    1 
ATOM   1074 C CA   . ASN A 1 72  ? -2.55786  -48.92789 6.47122   1.000 52.50617 ? 72  ASN A CA   1 
ATOM   1075 C C    . ASN A 1 72  ? -3.56058  -49.96881 5.99505   1.000 50.67170 ? 72  ASN A C    1 
ATOM   1076 O O    . ASN A 1 72  ? -3.33371  -50.60382 4.96023   1.000 57.87916 ? 72  ASN A O    1 
ATOM   1077 C CB   . ASN A 1 72  ? -1.19906  -49.60163 6.69683   1.000 60.70500 ? 72  ASN A CB   1 
ATOM   1078 C CG   . ASN A 1 72  ? -0.58943  -50.14196 5.41612   1.000 67.94981 ? 72  ASN A CG   1 
ATOM   1079 O OD1  . ASN A 1 72  ? -0.66856  -49.50883 4.36239   1.000 67.02888 ? 72  ASN A OD1  1 
ATOM   1080 N ND2  . ASN A 1 72  ? 0.01701   -51.32154 5.49970   1.000 73.13577 ? 72  ASN A ND2  1 
ATOM   1081 H H    . ASN A 1 72  ? -2.68777  -48.62381 8.40953   1.000 59.85152 ? 72  ASN A H    1 
ATOM   1082 H HA   . ASN A 1 72  ? -2.45735  -48.26671 5.76863   1.000 63.05769 ? 72  ASN A HA   1 
ATOM   1083 H HB2  . ASN A 1 72  ? -0.58307  -48.95259 7.07125   1.000 72.89629 ? 72  ASN A HB2  1 
ATOM   1084 H HB3  . ASN A 1 72  ? -1.31270  -50.34385 7.31091   1.000 72.89629 ? 72  ASN A HB3  1 
ATOM   1085 H HD21 . ASN A 1 72  ? 0.37804   -51.66988 4.80119   1.000 87.81322 ? 72  ASN A HD21 1 
ATOM   1086 H HD22 . ASN A 1 72  ? 0.04842   -51.73652 6.25230   1.000 87.81322 ? 72  ASN A HD22 1 
ATOM   1087 N N    . VAL A 1 73  ? -4.66473  -50.13845 6.71109   1.000 48.76347 ? 73  VAL A N    1 
ATOM   1088 C CA   . VAL A 1 73  ? -5.54564  -51.29389 6.57650   1.000 45.07341 ? 73  VAL A CA   1 
ATOM   1089 C C    . VAL A 1 73  ? -6.83543  -50.85250 5.89521   1.000 45.43370 ? 73  VAL A C    1 
ATOM   1090 O O    . VAL A 1 73  ? -7.53013  -49.95314 6.38276   1.000 40.24515 ? 73  VAL A O    1 
ATOM   1091 C CB   . VAL A 1 73  ? -5.81214  -51.92783 7.94867   1.000 55.22163 ? 73  VAL A CB   1 
ATOM   1092 C CG1  . VAL A 1 73  ? -7.08653  -52.74369 7.95455   1.000 52.78890 ? 73  VAL A CG1  1 
ATOM   1093 C CG2  . VAL A 1 73  ? -4.61746  -52.78677 8.36518   1.000 58.94761 ? 73  VAL A CG2  1 
ATOM   1094 H H    . VAL A 1 73  ? -4.93537  -49.57714 7.30379   1.000 58.56645 ? 73  VAL A H    1 
ATOM   1095 H HA   . VAL A 1 73  ? -5.13481  -51.95531 5.99801   1.000 54.13838 ? 73  VAL A HA   1 
ATOM   1096 H HB   . VAL A 1 73  ? -5.93046  -51.21604 8.59694   1.000 66.31624 ? 73  VAL A HB   1 
ATOM   1097 H HG11 . VAL A 1 73  ? -7.20602  -53.13643 8.83341   1.000 63.39697 ? 73  VAL A HG11 1 
ATOM   1098 H HG12 . VAL A 1 73  ? -7.83477  -52.16213 7.74762   1.000 63.39697 ? 73  VAL A HG12 1 
ATOM   1099 H HG13 . VAL A 1 73  ? -7.01670  -53.44332 7.28632   1.000 63.39697 ? 73  VAL A HG13 1 
ATOM   1100 H HG21 . VAL A 1 73  ? -4.81107  -53.20425 9.21906   1.000 70.78743 ? 73  VAL A HG21 1 
ATOM   1101 H HG22 . VAL A 1 73  ? -4.46746  -53.46748 7.69062   1.000 70.78743 ? 73  VAL A HG22 1 
ATOM   1102 H HG23 . VAL A 1 73  ? -3.83369  -52.22072 8.44389   1.000 70.78743 ? 73  VAL A HG23 1 
ATOM   1103 N N    . GLN A 1 74  ? -7.16429  -51.51117 4.78182   1.000 43.22023 ? 74  GLN A N    1 
ATOM   1104 C CA   . GLN A 1 74  ? -8.36053  -51.19756 4.00971   1.000 42.44759 ? 74  GLN A CA   1 
ATOM   1105 C C    . GLN A 1 74  ? -9.59885  -51.80183 4.66073   1.000 41.98377 ? 74  GLN A C    1 
ATOM   1106 O O    . GLN A 1 74  ? -9.58465  -52.95525 5.09814   1.000 46.50393 ? 74  GLN A O    1 
ATOM   1107 C CB   . GLN A 1 74  ? -8.21611  -51.73882 2.58384   1.000 42.30808 ? 74  GLN A CB   1 
ATOM   1108 C CG   . GLN A 1 74  ? -8.92045  -50.92376 1.52297   1.000 49.94278 ? 74  GLN A CG   1 
ATOM   1109 C CD   . GLN A 1 74  ? -8.24317  -49.58767 1.29401   1.000 48.93981 ? 74  GLN A CD   1 
ATOM   1110 O OE1  . GLN A 1 74  ? -7.03535  -49.44897 1.49765   1.000 45.83582 ? 74  GLN A OE1  1 
ATOM   1111 N NE2  . GLN A 1 74  ? -9.02041  -48.59053 0.88462   1.000 53.19394 ? 74  GLN A NE2  1 
ATOM   1112 H H    . GLN A 1 74  ? -6.70097  -52.15482 4.44917   1.000 51.91457 ? 74  GLN A H    1 
ATOM   1113 H HA   . GLN A 1 74  ? -8.47685  -50.23528 3.97259   1.000 50.98740 ? 74  GLN A HA   1 
ATOM   1114 H HB2  . GLN A 1 74  ? -7.27329  -51.76091 2.35688   1.000 50.81999 ? 74  GLN A HB2  1 
ATOM   1115 H HB3  . GLN A 1 74  ? -8.58515  -52.63544 2.55598   1.000 50.81999 ? 74  GLN A HB3  1 
ATOM   1116 H HG2  . GLN A 1 74  ? -8.91397  -51.41466 0.68639   1.000 59.98162 ? 74  GLN A HG2  1 
ATOM   1117 H HG3  . GLN A 1 74  ? -9.83414  -50.75692 1.80266   1.000 59.98162 ? 74  GLN A HG3  1 
ATOM   1118 H HE21 . GLN A 1 74  ? -8.68233  -47.81293 0.74093   1.000 63.88302 ? 74  GLN A HE21 1 
ATOM   1119 H HE22 . GLN A 1 74  ? -9.86148  -48.72283 0.76336   1.000 63.88302 ? 74  GLN A HE22 1 
ATOM   1120 N N    . LEU A 1 75  ? -10.67544 -51.02272 4.71896   1.000 33.43096 ? 75  LEU A N    1 
ATOM   1121 C CA   . LEU A 1 75  ? -11.95251 -51.49981 5.22968   1.000 33.66639 ? 75  LEU A CA   1 
ATOM   1122 C C    . LEU A 1 75  ? -12.86847 -51.82700 4.05762   1.000 31.80038 ? 75  LEU A C    1 
ATOM   1123 O O    . LEU A 1 75  ? -12.84168 -51.16266 3.02249   1.000 33.35126 ? 75  LEU A O    1 
ATOM   1124 C CB   . LEU A 1 75  ? -12.62040 -50.46035 6.12999   1.000 31.15992 ? 75  LEU A CB   1 
ATOM   1125 C CG   . LEU A 1 75  ? -11.83455 -50.00596 7.35986   1.000 32.89511 ? 75  LEU A CG   1 
ATOM   1126 C CD1  . LEU A 1 75  ? -12.69287 -49.12562 8.26900   1.000 30.79608 ? 75  LEU A CD1  1 
ATOM   1127 C CD2  . LEU A 1 75  ? -11.31206 -51.20355 8.12864   1.000 40.00438 ? 75  LEU A CD2  1 
ATOM   1128 H H    . LEU A 1 75  ? -10.68898 -50.20150 4.46397   1.000 40.16744 ? 75  LEU A H    1 
ATOM   1129 H HA   . LEU A 1 75  ? -11.81249 -52.29834 5.76226   1.000 40.44996 ? 75  LEU A HA   1 
ATOM   1130 H HB2  . LEU A 1 75  ? -12.79376 -49.66932 5.59602   1.000 37.44220 ? 75  LEU A HB2  1 
ATOM   1131 H HB3  . LEU A 1 75  ? -13.45625 -50.83448 6.44980   1.000 37.44220 ? 75  LEU A HB3  1 
ATOM   1132 H HG   . LEU A 1 75  ? -11.07776 -49.47689 7.06281   1.000 39.52443 ? 75  LEU A HG   1 
ATOM   1133 H HD11 . LEU A 1 75  ? -12.15175 -48.81764 9.01280   1.000 37.00559 ? 75  LEU A HD11 1 
ATOM   1134 H HD12 . LEU A 1 75  ? -13.01705 -48.36671 7.75923   1.000 37.00559 ? 75  LEU A HD12 1 
ATOM   1135 H HD13 . LEU A 1 75  ? -13.44159 -49.64708 8.59823   1.000 37.00559 ? 75  LEU A HD13 1 
ATOM   1136 H HD21 . LEU A 1 75  ? -10.99588 -50.90809 8.99676   1.000 48.05555 ? 75  LEU A HD21 1 
ATOM   1137 H HD22 . LEU A 1 75  ? -12.03056 -51.84575 8.23930   1.000 48.05555 ? 75  LEU A HD22 1 
ATOM   1138 H HD23 . LEU A 1 75  ? -10.58322 -51.60524 7.63031   1.000 48.05555 ? 75  LEU A HD23 1 
ATOM   1139 N N    . ARG A 1 76  ? -13.68927 -52.86037 4.23253   1.000 29.95533 ? 76  ARG A N    1 
ATOM   1140 C CA   . ARG A 1 76  ? -14.58533 -53.33200 3.18063   1.000 31.37098 ? 76  ARG A CA   1 
ATOM   1141 C C    . ARG A 1 76  ? -15.94273 -52.66018 3.34106   1.000 29.30273 ? 76  ARG A C    1 
ATOM   1142 O O    . ARG A 1 76  ? -16.60544 -52.83633 4.36729   1.000 29.00927 ? 76  ARG A O    1 
ATOM   1143 C CB   . ARG A 1 76  ? -14.71403 -54.85214 3.25300   1.000 32.46910 ? 76  ARG A CB   1 
ATOM   1144 C CG   . ARG A 1 76  ? -15.32360 -55.50518 2.02849   1.000 38.55785 ? 76  ARG A CG   1 
ATOM   1145 C CD   . ARG A 1 76  ? -15.29642 -57.02973 2.15134   1.000 43.12888 ? 76  ARG A CD   1 
ATOM   1146 N NE   . ARG A 1 76  ? -13.93807 -57.55759 2.09006   1.000 44.59381 ? 76  ARG A NE   1 
ATOM   1147 C CZ   . ARG A 1 76  ? -13.27034 -57.77682 0.96457   1.000 41.70941 ? 76  ARG A CZ   1 
ATOM   1148 N NH1  . ARG A 1 76  ? -13.80938 -57.52771 -0.21807  1.000 33.71973 ? 76  ARG A NH1  1 
ATOM   1149 N NH2  . ARG A 1 76  ? -12.02888 -58.25007 1.02712   1.000 39.85552 ? 76  ARG A NH2  1 
ATOM   1150 H H    . ARG A 1 76  ? -13.74605 -53.31114 4.96272   1.000 35.99669 ? 76  ARG A H    1 
ATOM   1151 H HA   . ARG A 1 76  ? -14.23361 -53.09255 2.30892   1.000 37.69546 ? 76  ARG A HA   1 
ATOM   1152 H HB2  . ARG A 1 76  ? -13.82844 -55.22938 3.37271   1.000 39.01321 ? 76  ARG A HB2  1 
ATOM   1153 H HB3  . ARG A 1 76  ? -15.27549 -55.07645 4.01151   1.000 39.01321 ? 76  ARG A HB3  1 
ATOM   1154 H HG2  . ARG A 1 76  ? -16.24635 -55.22084 1.93583   1.000 46.31971 ? 76  ARG A HG2  1 
ATOM   1155 H HG3  . ARG A 1 76  ? -14.81754 -55.25137 1.24084   1.000 46.31971 ? 76  ARG A HG3  1 
ATOM   1156 H HD2  . ARG A 1 76  ? -15.68415 -57.28855 3.00198   1.000 51.80494 ? 76  ARG A HD2  1 
ATOM   1157 H HD3  . ARG A 1 76  ? -15.80569 -57.41797 1.42277   1.000 51.80494 ? 76  ARG A HD3  1 
ATOM   1158 H HE   . ARG A 1 76  ? -13.54383 -57.73874 2.83259   1.000 53.56287 ? 76  ARG A HE   1 
ATOM   1159 H HH11 . ARG A 1 76  ? -14.60956 -57.21672 -0.26901  1.000 40.51397 ? 76  ARG A HH11 1 
ATOM   1160 H HH12 . ARG A 1 76  ? -13.35950 -57.67682 -0.93569  1.000 40.51397 ? 76  ARG A HH12 1 
ATOM   1161 H HH21 . ARG A 1 76  ? -11.66780 -58.41043 1.79100   1.000 47.87691 ? 76  ARG A HH21 1 
ATOM   1162 H HH22 . ARG A 1 76  ? -11.58725 -58.39570 0.30369   1.000 47.87691 ? 76  ARG A HH22 1 
ATOM   1163 N N    . VAL A 1 77  ? -16.36228 -51.90581 2.32595   1.000 27.07892 ? 77  VAL A N    1 
ATOM   1164 C CA   . VAL A 1 77  ? -17.62894 -51.18245 2.35249   1.000 27.56642 ? 77  VAL A CA   1 
ATOM   1165 C C    . VAL A 1 77  ? -18.73012 -52.08852 1.81447   1.000 27.43692 ? 77  VAL A C    1 
ATOM   1166 O O    . VAL A 1 77  ? -18.65143 -52.56387 0.67617   1.000 27.05358 ? 77  VAL A O    1 
ATOM   1167 C CB   . VAL A 1 77  ? -17.54304 -49.88646 1.52668   1.000 27.84543 ? 77  VAL A CB   1 
ATOM   1168 C CG1  . VAL A 1 77  ? -18.88884 -49.17186 1.48772   1.000 24.85188 ? 77  VAL A CG1  1 
ATOM   1169 C CG2  . VAL A 1 77  ? -16.46131 -48.98376 2.08650   1.000 28.91342 ? 77  VAL A CG2  1 
ATOM   1170 H H    . VAL A 1 77  ? -15.92042 -51.79598 1.59636   1.000 32.54499 ? 77  VAL A H    1 
ATOM   1171 H HA   . VAL A 1 77  ? -17.84175 -50.95819 3.27190   1.000 33.13000 ? 77  VAL A HA   1 
ATOM   1172 H HB   . VAL A 1 77  ? -17.30963 -50.11041 0.61221   1.000 33.46481 ? 77  VAL A HB   1 
ATOM   1173 H HG11 . VAL A 1 77  ? -18.79274 -48.34436 0.99083   1.000 29.87254 ? 77  VAL A HG11 1 
ATOM   1174 H HG12 . VAL A 1 77  ? -19.53856 -49.74560 1.05230   1.000 29.87254 ? 77  VAL A HG12 1 
ATOM   1175 H HG13 . VAL A 1 77  ? -19.17172 -48.98147 2.39581   1.000 29.87254 ? 77  VAL A HG13 1 
ATOM   1176 H HG21 . VAL A 1 77  ? -16.11878 -49.37243 2.90657   1.000 34.74639 ? 77  VAL A HG21 1 
ATOM   1177 H HG22 . VAL A 1 77  ? -15.74742 -48.90458 1.43460   1.000 34.74639 ? 77  VAL A HG22 1 
ATOM   1178 H HG23 . VAL A 1 77  ? -16.84175 -48.11017 2.26819   1.000 34.74639 ? 77  VAL A HG23 1 
ATOM   1179 N N    . ILE A 1 78  ? -19.77243 -52.29328 2.62430   1.000 26.57000 ? 78  ILE A N    1 
ATOM   1180 C CA   . ILE A 1 78  ? -20.86254 -53.20833 2.32285   1.000 28.84239 ? 78  ILE A CA   1 
ATOM   1181 C C    . ILE A 1 78  ? -22.21117 -52.49818 2.25228   1.000 27.66338 ? 78  ILE A C    1 
ATOM   1182 O O    . ILE A 1 78  ? -23.24333 -53.15394 2.09236   1.000 26.44031 ? 78  ILE A O    1 
ATOM   1183 C CB   . ILE A 1 78  ? -20.90391 -54.36525 3.34332   1.000 28.05896 ? 78  ILE A CB   1 
ATOM   1184 C CG1  . ILE A 1 78  ? -21.09901 -53.84168 4.76837   1.000 29.98463 ? 78  ILE A CG1  1 
ATOM   1185 C CG2  . ILE A 1 78  ? -19.61324 -55.17156 3.26077   1.000 30.50707 ? 78  ILE A CG2  1 
ATOM   1186 C CD1  . ILE A 1 78  ? -21.33829 -54.95448 5.80276   1.000 32.18867 ? 78  ILE A CD1  1 
ATOM   1187 H H    . ILE A 1 78  ? -19.86877 -51.89609 3.38097   1.000 31.93430 ? 78  ILE A H    1 
ATOM   1188 H HA   . ILE A 1 78  ? -20.70245 -53.58857 1.44496   1.000 34.66116 ? 78  ILE A HA   1 
ATOM   1189 H HB   . ILE A 1 78  ? -21.65982 -54.93204 3.12367   1.000 33.72104 ? 78  ILE A HB   1 
ATOM   1190 H HG12 . ILE A 1 78  ? -20.30350 -53.35459 5.03447   1.000 36.03185 ? 78  ILE A HG12 1 
ATOM   1191 H HG13 . ILE A 1 78  ? -21.86920 -53.25217 4.78247   1.000 36.03185 ? 78  ILE A HG13 1 
ATOM   1192 H HG21 . ILE A 1 78  ? -19.30174 -55.36187 4.15946   1.000 36.65878 ? 78  ILE A HG21 1 
ATOM   1193 H HG22 . ILE A 1 78  ? -19.78851 -56.00073 2.78890   1.000 36.65878 ? 78  ILE A HG22 1 
ATOM   1194 H HG23 . ILE A 1 78  ? -18.94714 -54.65330 2.78262   1.000 36.65878 ? 78  ILE A HG23 1 
ATOM   1195 H HD11 . ILE A 1 78  ? -20.49316 -55.38629 6.00328   1.000 38.67669 ? 78  ILE A HD11 1 
ATOM   1196 H HD12 . ILE A 1 78  ? -21.70869 -54.56207 6.60881   1.000 38.67669 ? 78  ILE A HD12 1 
ATOM   1197 H HD13 . ILE A 1 78  ? -21.96040 -55.60056 5.43336   1.000 38.67669 ? 78  ILE A HD13 1 
ATOM   1198 N N    . GLY A 1 79  ? -22.23457 -51.18249 2.34416   1.000 25.98376 ? 79  GLY A N    1 
ATOM   1199 C CA   . GLY A 1 79  ? -23.49645 -50.43663 2.13593   1.000 25.82634 ? 79  GLY A CA   1 
ATOM   1200 C C    . GLY A 1 79  ? -23.17537 -48.95796 2.27598   1.000 26.22869 ? 79  GLY A C    1 
ATOM   1201 O O    . GLY A 1 79  ? -22.20530 -48.54783 2.87908   1.000 26.12764 ? 79  GLY A O    1 
ATOM   1202 H H    . GLY A 1 79  ? -21.55242 -50.69012 2.52260   1.000 31.23080 ? 79  GLY A H    1 
ATOM   1203 H HA2  . GLY A 1 79  ? -23.85374 -50.61082 1.25112   1.000 31.04190 ? 79  GLY A HA2  1 
ATOM   1204 H HA3  . GLY A 1 79  ? -24.15691 -50.69159 2.79902   1.000 31.04190 ? 79  GLY A HA3  1 
ATOM   1205 N N    . HIS A 1 80  ? -24.06832 -48.16796 1.64189   1.000 25.43414 ? 80  HIS A N    1 
ATOM   1206 C CA   . HIS A 1 80  ? -23.88641 -46.70596 1.75033   1.000 25.44208 ? 80  HIS A CA   1 
ATOM   1207 C C    . HIS A 1 80  ? -25.24254 -46.01951 1.70170   1.000 26.50842 ? 80  HIS A C    1 
ATOM   1208 O O    . HIS A 1 80  ? -26.17568 -46.51208 1.06627   1.000 26.03461 ? 80  HIS A O    1 
ATOM   1209 C CB   . HIS A 1 80  ? -22.95856 -46.15009 0.65282   1.000 25.60187 ? 80  HIS A CB   1 
ATOM   1210 C CG   . HIS A 1 80  ? -23.49180 -46.29561 -0.73986  1.000 26.81956 ? 80  HIS A CG   1 
ATOM   1211 N ND1  . HIS A 1 80  ? -23.25632 -47.40893 -1.51784  1.000 26.02361 ? 80  HIS A ND1  1 
ATOM   1212 C CD2  . HIS A 1 80  ? -24.22726 -45.45280 -1.50466  1.000 25.33103 ? 80  HIS A CD2  1 
ATOM   1213 C CE1  . HIS A 1 80  ? -23.83006 -47.24975 -2.69623  1.000 24.63443 ? 80  HIS A CE1  1 
ATOM   1214 N NE2  . HIS A 1 80  ? -24.42923 -46.07395 -2.71327  1.000 27.25067 ? 80  HIS A NE2  1 
ATOM   1215 H H    . HIS A 1 80  ? -24.73938 -48.43737 1.17638   1.000 30.57126 ? 80  HIS A H    1 
ATOM   1216 H HA   . HIS A 1 80  ? -23.48160 -46.50464 2.60853   1.000 30.58078 ? 80  HIS A HA   1 
ATOM   1217 H HB2  . HIS A 1 80  ? -22.81826 -45.20426 0.81595   1.000 30.77254 ? 80  HIS A HB2  1 
ATOM   1218 H HB3  . HIS A 1 80  ? -22.11260 -46.62291 0.69400   1.000 30.77254 ? 80  HIS A HB3  1 
ATOM   1219 H HD1  . HIS A 1 80  ? -22.80586 -48.09962 -1.27366  1.000 31.27862 ? 80  HIS A HD1  1 
ATOM   1220 H HD2  . HIS A 1 80  ? -24.53723 -44.61149 -1.25766  1.000 30.44753 ? 80  HIS A HD2  1 
ATOM   1221 H HE1  . HIS A 1 80  ? -23.81460 -47.86237 -3.39577  1.000 29.61161 ? 80  HIS A HE1  1 
ATOM   1222 N N    . SER A 1 81  ? -25.33841 -44.87515 2.37831   1.000 25.48844 ? 81  SER A N    1 
ATOM   1223 C CA   . SER A 1 81  ? -26.56545 -44.08655 2.43367   1.000 25.09124 ? 81  SER A CA   1 
ATOM   1224 C C    . SER A 1 81  ? -26.18751 -42.62385 2.62849   1.000 25.05835 ? 81  SER A C    1 
ATOM   1225 O O    . SER A 1 81  ? -25.11032 -42.32353 3.14383   1.000 24.28027 ? 81  SER A O    1 
ATOM   1226 C CB   . SER A 1 81  ? -27.47307 -44.57489 3.56677   1.000 25.25806 ? 81  SER A CB   1 
ATOM   1227 O OG   . SER A 1 81  ? -26.85929 -44.36202 4.82633   1.000 36.56512 ? 81  SER A OG   1 
ATOM   1228 H H    . SER A 1 81  ? -24.69039 -44.52702 2.82381   1.000 30.63642 ? 81  SER A H    1 
ATOM   1229 H HA   . SER A 1 81  ? -27.05805 -44.15857 1.60117   1.000 30.15978 ? 81  SER A HA   1 
ATOM   1230 H HB2  . SER A 1 81  ? -28.30968 -44.08498 3.53557   1.000 30.35997 ? 81  SER A HB2  1 
ATOM   1231 H HB3  . SER A 1 81  ? -27.63969 -45.52358 3.45222   1.000 30.35997 ? 81  SER A HB3  1 
ATOM   1232 H HG   . SER A 1 81  ? -27.26648 -44.79355 5.42095   1.000 43.92843 ? 81  SER A HG   1 
ATOM   1233 N N    . MET A 1 82  ? -27.06228 -41.70891 2.20206   1.000 25.04090 ? 82  MET A N    1 
ATOM   1234 C CA   . MET A 1 82  ? -26.86974 -40.28394 2.43914   1.000 24.10523 ? 82  MET A CA   1 
ATOM   1235 C C    . MET A 1 82  ? -27.91467 -39.77747 3.42812   1.000 25.02805 ? 82  MET A C    1 
ATOM   1236 O O    . MET A 1 82  ? -29.11514 -39.96653 3.22032   1.000 23.58909 ? 82  MET A O    1 
ATOM   1237 C CB   . MET A 1 82  ? -26.95595 -39.47572 1.13621   1.000 24.82333 ? 82  MET A CB   1 
ATOM   1238 C CG   . MET A 1 82  ? -26.82219 -37.95958 1.30170   1.000 23.55234 ? 82  MET A CG   1 
ATOM   1239 S SD   . MET A 1 82  ? -26.63709 -37.10615 -0.28263  1.000 25.69864 ? 82  MET A SD   1 
ATOM   1240 C CE   . MET A 1 82  ? -28.19480 -37.47944 -1.10187  1.000 33.08507 ? 82  MET A CE   1 
ATOM   1241 H H    . MET A 1 82  ? -27.78126 -41.89600 1.76886   1.000 30.09937 ? 82  MET A H    1 
ATOM   1242 H HA   . MET A 1 82  ? -25.98416 -40.15620 2.81375   1.000 28.97657 ? 82  MET A HA   1 
ATOM   1243 H HB2  . MET A 1 82  ? -26.24290 -39.76744 0.54685   1.000 29.83829 ? 82  MET A HB2  1 
ATOM   1244 H HB3  . MET A 1 82  ? -27.81749 -39.64797 0.72514   1.000 29.83829 ? 82  MET A HB3  1 
ATOM   1245 H HG2  . MET A 1 82  ? -27.61788 -37.61650 1.73767   1.000 28.31309 ? 82  MET A HG2  1 
ATOM   1246 H HG3  . MET A 1 82  ? -26.03925 -37.76706 1.84100   1.000 28.31309 ? 82  MET A HG3  1 
ATOM   1247 H HE1  . MET A 1 82  ? -28.27368 -38.44044 -1.20754  1.000 39.75237 ? 82  MET A HE1  1 
ATOM   1248 H HE2  . MET A 1 82  ? -28.92546 -37.14536 -0.55834  1.000 39.75237 ? 82  MET A HE2  1 
ATOM   1249 H HE3  . MET A 1 82  ? -28.20552 -37.04910 -1.97111  1.000 39.75237 ? 82  MET A HE3  1 
ATOM   1250 N N    . GLN A 1 83  ? -27.44808 -39.13271 4.49830   1.000 21.19261 ? 83  GLN A N    1 
ATOM   1251 C CA   . GLN A 1 83  ? -28.30777 -38.53657 5.51627   1.000 23.05436 ? 83  GLN A CA   1 
ATOM   1252 C C    . GLN A 1 83  ? -28.00192 -37.04426 5.57376   1.000 22.00329 ? 83  GLN A C    1 
ATOM   1253 O O    . GLN A 1 83  ? -26.95203 -36.64222 6.09076   1.000 21.91138 ? 83  GLN A O    1 
ATOM   1254 C CB   . GLN A 1 83  ? -28.08739 -39.20126 6.87810   1.000 23.89045 ? 83  GLN A CB   1 
ATOM   1255 C CG   . GLN A 1 83  ? -28.75823 -38.47310 8.03457   1.000 23.86037 ? 83  GLN A CG   1 
ATOM   1256 C CD   . GLN A 1 83  ? -28.66368 -39.19810 9.37985   1.000 27.65387 ? 83  GLN A CD   1 
ATOM   1257 O OE1  . GLN A 1 83  ? -27.73780 -39.96964 9.64142   1.000 27.47072 ? 83  GLN A OE1  1 
ATOM   1258 N NE2  . GLN A 1 83  ? -29.63122 -38.92700 10.24814  1.000 27.89588 ? 83  GLN A NE2  1 
ATOM   1259 H H    . GLN A 1 83  ? -26.61014 -39.02551 4.65948   1.000 25.48143 ? 83  GLN A H    1 
ATOM   1260 H HA   . GLN A 1 83  ? -29.23861 -38.65268 5.26940   1.000 27.71552 ? 83  GLN A HA   1 
ATOM   1261 H HB2  . GLN A 1 83  ? -28.44712 -40.10156 6.84704   1.000 28.71883 ? 83  GLN A HB2  1 
ATOM   1262 H HB3  . GLN A 1 83  ? -27.13501 -39.23063 7.05980   1.000 28.71883 ? 83  GLN A HB3  1 
ATOM   1263 H HG2  . GLN A 1 83  ? -28.33787 -37.60525 8.13953   1.000 28.68274 ? 83  GLN A HG2  1 
ATOM   1264 H HG3  . GLN A 1 83  ? -29.69932 -38.36296 7.82688   1.000 28.68274 ? 83  GLN A HG3  1 
ATOM   1265 H HE21 . GLN A 1 83  ? -30.25606 -38.37503 10.03719  1.000 33.52534 ? 83  GLN A HE21 1 
ATOM   1266 H HE22 . GLN A 1 83  ? -29.63296 -39.30342 11.02138  1.000 33.52534 ? 83  GLN A HE22 1 
ATOM   1267 N N    . ASN A 1 84  ? -28.91630 -36.22585 5.05608   1.000 21.98349 ? 84  ASN A N    1 
ATOM   1268 C CA   . ASN A 1 84  ? -28.65435 -34.78815 4.97920   1.000 21.33376 ? 84  ASN A CA   1 
ATOM   1269 C C    . ASN A 1 84  ? -27.32506 -34.58216 4.27436   1.000 22.10601 ? 84  ASN A C    1 
ATOM   1270 O O    . ASN A 1 84  ? -27.16645 -35.04121 3.13699   1.000 23.58333 ? 84  ASN A O    1 
ATOM   1271 C CB   . ASN A 1 84  ? -28.71773 -34.20286 6.37449   1.000 22.98263 ? 84  ASN A CB   1 
ATOM   1272 C CG   . ASN A 1 84  ? -30.06519 -34.44568 7.00979   1.000 25.26262 ? 84  ASN A CG   1 
ATOM   1273 O OD1  . ASN A 1 84  ? -31.09980 -34.13223 6.42320   1.000 25.74116 ? 84  ASN A OD1  1 
ATOM   1274 N ND2  . ASN A 1 84  ? -30.06894 -35.06720 8.18013   1.000 24.43211 ? 84  ASN A ND2  1 
ATOM   1275 H H    . ASN A 1 84  ? -29.68070 -36.47239 4.74866   1.000 26.43048 ? 84  ASN A H    1 
ATOM   1276 H HA   . ASN A 1 84  ? -29.31904 -34.30596 4.46288   1.000 25.65080 ? 84  ASN A HA   1 
ATOM   1277 H HB2  . ASN A 1 84  ? -28.03861 -34.61818 6.92876   1.000 27.62945 ? 84  ASN A HB2  1 
ATOM   1278 H HB3  . ASN A 1 84  ? -28.56883 -33.24544 6.32886   1.000 27.62945 ? 84  ASN A HB3  1 
ATOM   1279 H HD21 . ASN A 1 84  ? -30.81351 -35.22715 8.57967   1.000 29.36882 ? 84  ASN A HD21 1 
ATOM   1280 H HD22 . ASN A 1 84  ? -29.32681 -35.31062 8.54012   1.000 29.36882 ? 84  ASN A HD22 1 
ATOM   1281 N N    . CYS A 1 85  ? -26.35530 -33.92302 4.90400   1.000 20.79838 ? 85  CYS A N    1 
ATOM   1282 C CA   . CYS A 1 85  ? -25.11267 -33.63138 4.20927   1.000 20.28629 ? 85  CYS A CA   1 
ATOM   1283 C C    . CYS A 1 85  ? -23.97371 -34.59052 4.54261   1.000 21.26478 ? 85  CYS A C    1 
ATOM   1284 O O    . CYS A 1 85  ? -22.82227 -34.27381 4.22934   1.000 19.07976 ? 85  CYS A O    1 
ATOM   1285 C CB   . CYS A 1 85  ? -24.65466 -32.20277 4.49842   1.000 19.69095 ? 85  CYS A CB   1 
ATOM   1286 S SG   . CYS A 1 85  ? -25.84411 -30.99721 3.92309   1.000 24.37886 ? 85  CYS A SG   1 
ATOM   1287 H H    . CYS A 1 85  ? -26.39672 -33.64230 5.71584   1.000 25.00834 ? 85  CYS A H    1 
ATOM   1288 H HA   . CYS A 1 85  ? -25.30329 -33.71887 3.26222   1.000 24.39384 ? 85  CYS A HA   1 
ATOM   1289 H HB2  . CYS A 1 85  ? -24.54483 -32.08993 5.45556   1.000 23.67943 ? 85  CYS A HB2  1 
ATOM   1290 H HB3  . CYS A 1 85  ? -23.81214 -32.03959 4.04629   1.000 23.67943 ? 85  CYS A HB3  1 
ATOM   1291 H HG   . CYS A 1 85  ? -25.93833 -31.08008 2.72966   1.000 29.30493 ? 85  CYS A HG   1 
ATOM   1292 N N    . VAL A 1 86  ? -24.25114 -35.74442 5.15746   1.000 20.51069 ? 86  VAL A N    1 
ATOM   1293 C CA   . VAL A 1 86  ? -23.19312 -36.71698 5.39661   1.000 20.96082 ? 86  VAL A CA   1 
ATOM   1294 C C    . VAL A 1 86  ? -23.56421 -38.03102 4.72737   1.000 21.95771 ? 86  VAL A C    1 
ATOM   1295 O O    . VAL A 1 86  ? -24.73460 -38.32010 4.45782   1.000 22.87237 ? 86  VAL A O    1 
ATOM   1296 C CB   . VAL A 1 86  ? -22.88085 -36.98545 6.89140   1.000 21.37262 ? 86  VAL A CB   1 
ATOM   1297 C CG1  . VAL A 1 86  ? -22.28999 -35.74669 7.55740   1.000 21.33489 ? 86  VAL A CG1  1 
ATOM   1298 C CG2  . VAL A 1 86  ? -24.10964 -37.52048 7.63573   1.000 25.38261 ? 86  VAL A CG2  1 
ATOM   1299 H H    . VAL A 1 86  ? -25.03018 -35.97716 5.43768   1.000 24.66311 ? 86  VAL A H    1 
ATOM   1300 H HA   . VAL A 1 86  ? -22.39133 -36.35196 4.99069   1.000 25.20328 ? 86  VAL A HA   1 
ATOM   1301 H HB   . VAL A 1 86  ? -22.20719 -37.68134 6.94443   1.000 25.69744 ? 86  VAL A HB   1 
ATOM   1302 H HG11 . VAL A 1 86  ? -22.26372 -35.88620 8.51695   1.000 25.65216 ? 86  VAL A HG11 1 
ATOM   1303 H HG12 . VAL A 1 86  ? -21.39211 -35.60420 7.21915   1.000 25.65216 ? 86  VAL A HG12 1 
ATOM   1304 H HG13 . VAL A 1 86  ? -22.84719 -34.98034 7.34970   1.000 25.65216 ? 86  VAL A HG13 1 
ATOM   1305 H HG21 . VAL A 1 86  ? -24.78471 -37.77628 6.98785   1.000 30.50943 ? 86  VAL A HG21 1 
ATOM   1306 H HG22 . VAL A 1 86  ? -23.84842 -38.29149 8.16319   1.000 30.50943 ? 86  VAL A HG22 1 
ATOM   1307 H HG23 . VAL A 1 86  ? -24.45517 -36.82433 8.21615   1.000 30.50943 ? 86  VAL A HG23 1 
ATOM   1308 N N    . LEU A 1 87  ? -22.53301 -38.82317 4.45408   1.000 21.43963 ? 87  LEU A N    1 
ATOM   1309 C CA   . LEU A 1 87  ? -22.68018 -40.19535 4.02294   1.000 22.66514 ? 87  LEU A CA   1 
ATOM   1310 C C    . LEU A 1 87  ? -22.38043 -41.10566 5.19974   1.000 22.13713 ? 87  LEU A C    1 
ATOM   1311 O O    . LEU A 1 87  ? -21.49287 -40.82168 6.01087   1.000 21.51264 ? 87  LEU A O    1 
ATOM   1312 C CB   . LEU A 1 87  ? -21.72617 -40.55622 2.89317   1.000 21.86812 ? 87  LEU A CB   1 
ATOM   1313 C CG   . LEU A 1 87  ? -21.82959 -39.79076 1.58435   1.000 25.45487 ? 87  LEU A CG   1 
ATOM   1314 C CD1  . LEU A 1 87  ? -20.87010 -40.40978 0.57652   1.000 27.82097 ? 87  LEU A CD1  1 
ATOM   1315 C CD2  . LEU A 1 87  ? -23.26215 -39.78247 1.08508   1.000 26.18882 ? 87  LEU A CD2  1 
ATOM   1316 H H    . LEU A 1 87  ? -21.71220 -38.57387 4.51507   1.000 25.77785 ? 87  LEU A H    1 
ATOM   1317 H HA   . LEU A 1 87  ? -23.58616 -40.32473 3.70146   1.000 27.24846 ? 87  LEU A HA   1 
ATOM   1318 H HB2  . LEU A 1 87  ? -20.82249 -40.42402 3.21995   1.000 26.29204 ? 87  LEU A HB2  1 
ATOM   1319 H HB3  . LEU A 1 87  ? -21.86774 -41.49146 2.67826   1.000 26.29204 ? 87  LEU A HB3  1 
ATOM   1320 H HG   . LEU A 1 87  ? -21.57890 -38.86188 1.70776   1.000 30.59613 ? 87  LEU A HG   1 
ATOM   1321 H HD11 . LEU A 1 87  ? -21.20739 -41.28017 0.31278   1.000 33.43546 ? 87  LEU A HD11 1 
ATOM   1322 H HD12 . LEU A 1 87  ? -20.80901 -39.82992 -0.19869  1.000 33.43546 ? 87  LEU A HD12 1 
ATOM   1323 H HD13 . LEU A 1 87  ? -19.99705 -40.50430 0.98852   1.000 33.43546 ? 87  LEU A HD13 1 
ATOM   1324 H HD21 . LEU A 1 87  ? -23.69081 -40.61393 1.34164   1.000 31.47688 ? 87  LEU A HD21 1 
ATOM   1325 H HD22 . LEU A 1 87  ? -23.73088 -39.03217 1.48287   1.000 31.47688 ? 87  LEU A HD22 1 
ATOM   1326 H HD23 . LEU A 1 87  ? -23.25936 -39.69614 0.11893   1.000 31.47688 ? 87  LEU A HD23 1 
ATOM   1327 N N    . LYS A 1 88  ? -23.11527 -42.19816 5.27367   1.000 22.97792 ? 88  LYS A N    1 
ATOM   1328 C CA   . LYS A 1 88  ? -22.86195 -43.28273 6.21066   1.000 23.44378 ? 88  LYS A CA   1 
ATOM   1329 C C    . LYS A 1 88  ? -22.41680 -44.45917 5.36057   1.000 23.74414 ? 88  LYS A C    1 
ATOM   1330 O O    . LYS A 1 88  ? -23.19465 -44.96138 4.54237   1.000 24.30366 ? 88  LYS A O    1 
ATOM   1331 C CB   . LYS A 1 88  ? -24.10765 -43.60660 7.02072   1.000 25.30795 ? 88  LYS A CB   1 
ATOM   1332 C CG   . LYS A 1 88  ? -24.60289 -42.41350 7.80793   1.000 27.43137 ? 88  LYS A CG   1 
ATOM   1333 C CD   . LYS A 1 88  ? -25.60218 -42.79107 8.88294   1.000 30.48189 ? 88  LYS A CD   1 
ATOM   1334 C CE   . LYS A 1 88  ? -26.98331 -43.04457 8.30973   1.000 36.02255 ? 88  LYS A CE   1 
ATOM   1335 N NZ   . LYS A 1 88  ? -27.98621 -43.12942 9.40145   1.000 38.71754 ? 88  LYS A NZ   1 
ATOM   1336 H H    . LYS A 1 88  ? -23.79722 -42.34376 4.77034   1.000 27.62379 ? 88  LYS A H    1 
ATOM   1337 H HA   . LYS A 1 88  ? -22.16522 -43.04966 6.84402   1.000 28.18283 ? 88  LYS A HA   1 
ATOM   1338 H HB2  . LYS A 1 88  ? -24.81458 -43.88669 6.41848   1.000 30.41983 ? 88  LYS A HB2  1 
ATOM   1339 H HB3  . LYS A 1 88  ? -23.90350 -44.31889 7.64671   1.000 30.41983 ? 88  LYS A HB3  1 
ATOM   1340 H HG2  . LYS A 1 88  ? -23.84773 -41.98379 8.23918   1.000 32.96793 ? 88  LYS A HG2  1 
ATOM   1341 H HG3  . LYS A 1 88  ? -25.03615 -41.79253 7.20165   1.000 32.96793 ? 88  LYS A HG3  1 
ATOM   1342 H HD2  . LYS A 1 88  ? -25.30453 -43.60127 9.32554   1.000 36.62856 ? 88  LYS A HD2  1 
ATOM   1343 H HD3  . LYS A 1 88  ? -25.66902 -42.06745 9.52544   1.000 36.62856 ? 88  LYS A HD3  1 
ATOM   1344 H HE2  . LYS A 1 88  ? -27.22937 -42.31600 7.71851   1.000 43.27735 ? 88  LYS A HE2  1 
ATOM   1345 H HE3  . LYS A 1 88  ? -26.98458 -43.88280 7.82161   1.000 43.27735 ? 88  LYS A HE3  1 
ATOM   1346 H HZ1  . LYS A 1 88  ? -28.07498 -42.33639 9.79556   1.000 46.51134 ? 88  LYS A HZ1  1 
ATOM   1347 H HZ2  . LYS A 1 88  ? -28.77466 -43.37803 9.07184   1.000 46.51134 ? 88  LYS A HZ2  1 
ATOM   1348 H HZ3  . LYS A 1 88  ? -27.72577 -43.72603 10.00835  1.000 46.51134 ? 88  LYS A HZ3  1 
ATOM   1349 N N    . LEU A 1 89  ? -21.16766 -44.87532 5.52013   1.000 22.81060 ? 89  LEU A N    1 
ATOM   1350 C CA   . LEU A 1 89  ? -20.63869 -46.03304 4.81908   1.000 22.52061 ? 89  LEU A CA   1 
ATOM   1351 C C    . LEU A 1 89  ? -20.60931 -47.20899 5.78655   1.000 23.17062 ? 89  LEU A C    1 
ATOM   1352 O O    . LEU A 1 89  ? -19.90266 -47.16137 6.80169   1.000 22.57821 ? 89  LEU A O    1 
ATOM   1353 C CB   . LEU A 1 89  ? -19.24126 -45.74189 4.26918   1.000 22.43526 ? 89  LEU A CB   1 
ATOM   1354 C CG   . LEU A 1 89  ? -19.15206 -44.43443 3.48265   1.000 23.85253 ? 89  LEU A CG   1 
ATOM   1355 C CD1  . LEU A 1 89  ? -17.71826 -44.17448 3.01132   1.000 24.41862 ? 89  LEU A CD1  1 
ATOM   1356 C CD2  . LEU A 1 89  ? -20.10271 -44.48357 2.31177   1.000 24.25566 ? 89  LEU A CD2  1 
ATOM   1357 H H    . LEU A 1 89  ? -20.59750 -44.49493 6.03958   1.000 27.42301 ? 89  LEU A H    1 
ATOM   1358 H HA   . LEU A 1 89  ? -21.21317 -46.26095 4.07147   1.000 27.07502 ? 89  LEU A HA   1 
ATOM   1359 H HB2  . LEU A 1 89  ? -18.61981 -45.68503 5.01179   1.000 26.97261 ? 89  LEU A HB2  1 
ATOM   1360 H HB3  . LEU A 1 89  ? -18.98338 -46.46420 3.67533   1.000 26.97261 ? 89  LEU A HB3  1 
ATOM   1361 H HG   . LEU A 1 89  ? -19.40383 -43.69421 4.05676   1.000 28.67333 ? 89  LEU A HG   1 
ATOM   1362 H HD11 . LEU A 1 89  ? -17.46879 -44.85628 2.36804   1.000 29.35263 ? 89  LEU A HD11 1 
ATOM   1363 H HD12 . LEU A 1 89  ? -17.67579 -43.29810 2.59772   1.000 29.35263 ? 89  LEU A HD12 1 
ATOM   1364 H HD13 . LEU A 1 89  ? -17.12324 -44.20824 3.77664   1.000 29.35263 ? 89  LEU A HD13 1 
ATOM   1365 H HD21 . LEU A 1 89  ? -19.88283 -43.76690 1.69618   1.000 29.15708 ? 89  LEU A HD21 1 
ATOM   1366 H HD22 . LEU A 1 89  ? -20.01212 -45.34093 1.86721   1.000 29.15708 ? 89  LEU A HD22 1 
ATOM   1367 H HD23 . LEU A 1 89  ? -21.01000 -44.37373 2.63679   1.000 29.15708 ? 89  LEU A HD23 1 
ATOM   1368 N N    . LYS A 1 90  ? -21.38589 -48.24360 5.49478   1.000 23.05914 ? 90  LYS A N    1 
ATOM   1369 C CA   . LYS A 1 90  ? -21.34597 -49.43217 6.33532   1.000 23.46117 ? 90  LYS A CA   1 
ATOM   1370 C C    . LYS A 1 90  ? -20.15498 -50.26840 5.89948   1.000 23.50744 ? 90  LYS A C    1 
ATOM   1371 O O    . LYS A 1 90  ? -19.94647 -50.48637 4.69952   1.000 24.85620 ? 90  LYS A O    1 
ATOM   1372 C CB   . LYS A 1 90  ? -22.63124 -50.24633 6.24707   1.000 27.43673 ? 90  LYS A CB   1 
ATOM   1373 C CG   . LYS A 1 90  ? -22.68109 -51.35780 7.30356   1.000 30.62673 ? 90  LYS A CG   1 
ATOM   1374 C CD   . LYS A 1 90  ? -23.95885 -52.17767 7.26729   1.000 40.02121 ? 90  LYS A CD   1 
ATOM   1375 C CE   . LYS A 1 90  ? -24.10196 -53.00369 8.54274   1.000 49.10348 ? 90  LYS A CE   1 
ATOM   1376 N NZ   . LYS A 1 90  ? -25.14826 -54.05080 8.41075   1.000 55.18646 ? 90  LYS A NZ   1 
ATOM   1377 H H    . LYS A 1 90  ? -21.93182 -48.28156 4.83137   1.000 27.72126 ? 90  LYS A H    1 
ATOM   1378 H HA   . LYS A 1 90  ? -21.25679 -49.17307 7.26581   1.000 28.20370 ? 90  LYS A HA   1 
ATOM   1379 H HB2  . LYS A 1 90  ? -23.39051 -49.65932 6.38790   1.000 32.97437 ? 90  LYS A HB2  1 
ATOM   1380 H HB3  . LYS A 1 90  ? -22.68814 -50.65785 5.37054   1.000 32.97437 ? 90  LYS A HB3  1 
ATOM   1381 H HG2  . LYS A 1 90  ? -21.93743 -51.96296 7.15635   1.000 36.80236 ? 90  LYS A HG2  1 
ATOM   1382 H HG3  . LYS A 1 90  ? -22.61266 -50.95606 8.18380   1.000 36.80236 ? 90  LYS A HG3  1 
ATOM   1383 H HD2  . LYS A 1 90  ? -24.72332 -51.58489 7.19586   1.000 48.07574 ? 90  LYS A HD2  1 
ATOM   1384 H HD3  . LYS A 1 90  ? -23.93568 -52.78203 6.50893   1.000 48.07574 ? 90  LYS A HD3  1 
ATOM   1385 H HE2  . LYS A 1 90  ? -23.25807 -53.44088 8.73670   1.000 58.97446 ? 90  LYS A HE2  1 
ATOM   1386 H HE3  . LYS A 1 90  ? -24.34891 -52.41889 9.27617   1.000 58.97446 ? 90  LYS A HE3  1 
ATOM   1387 H HZ1  . LYS A 1 90  ? -25.11630 -54.60268 9.10826   1.000 66.27405 ? 90  LYS A HZ1  1 
ATOM   1388 H HZ2  . LYS A 1 90  ? -25.95376 -53.67376 8.37744   1.000 66.27405 ? 90  LYS A HZ2  1 
ATOM   1389 H HZ3  . LYS A 1 90  ? -25.01765 -54.51940 7.66546   1.000 66.27405 ? 90  LYS A HZ3  1 
ATOM   1390 N N    . VAL A 1 91  ? -19.36208 -50.71360 6.86993   1.000 24.39558 ? 91  VAL A N    1 
ATOM   1391 C CA   . VAL A 1 91  ? -18.18700 -51.53905 6.62626   1.000 24.17227 ? 91  VAL A CA   1 
ATOM   1392 C C    . VAL A 1 91  ? -18.38168 -52.86431 7.36193   1.000 26.08449 ? 91  VAL A C    1 
ATOM   1393 O O    . VAL A 1 91  ? -19.27008 -53.00408 8.20290   1.000 27.19293 ? 91  VAL A O    1 
ATOM   1394 C CB   . VAL A 1 91  ? -16.88796 -50.83074 7.06183   1.000 25.16003 ? 91  VAL A CB   1 
ATOM   1395 C CG1  . VAL A 1 91  ? -16.67992 -49.57397 6.22076   1.000 26.51346 ? 91  VAL A CG1  1 
ATOM   1396 C CG2  . VAL A 1 91  ? -16.91285 -50.47249 8.54305   1.000 25.51834 ? 91  VAL A CG2  1 
ATOM   1397 H H    . VAL A 1 91  ? -19.48969 -50.54447 7.70342   1.000 29.32498 ? 91  VAL A H    1 
ATOM   1398 H HA   . VAL A 1 91  ? -18.10963 -51.73449 5.67931   1.000 29.05702 ? 91  VAL A HA   1 
ATOM   1399 H HB   . VAL A 1 91  ? -16.14517 -51.43881 6.92253   1.000 30.24232 ? 91  VAL A HB   1 
ATOM   1400 H HG11 . VAL A 1 91  ? -16.89646 -49.77313 5.29645   1.000 31.86644 ? 91  VAL A HG11 1 
ATOM   1401 H HG12 . VAL A 1 91  ? -17.26117 -48.87197 6.55279   1.000 31.86644 ? 91  VAL A HG12 1 
ATOM   1402 H HG13 . VAL A 1 91  ? -15.75303 -49.29680 6.29102   1.000 31.86644 ? 91  VAL A HG13 1 
ATOM   1403 H HG21 . VAL A 1 91  ? -16.17200 -49.87696 8.73641   1.000 30.67230 ? 91  VAL A HG21 1 
ATOM   1404 H HG22 . VAL A 1 91  ? -17.75287 -50.03265 8.74750   1.000 30.67230 ? 91  VAL A HG22 1 
ATOM   1405 H HG23 . VAL A 1 91  ? -16.82914 -51.28518 9.06596   1.000 30.67230 ? 91  VAL A HG23 1 
ATOM   1406 N N    . ASP A 1 92  ? -17.55275 -53.85375 7.01958   1.000 28.80164 ? 92  ASP A N    1 
ATOM   1407 C CA   . ASP A 1 92  ? -17.74025 -55.19706 7.55783   1.000 30.59056 ? 92  ASP A CA   1 
ATOM   1408 C C    . ASP A 1 92  ? -17.03940 -55.41654 8.89403   1.000 31.28193 ? 92  ASP A C    1 
ATOM   1409 O O    . ASP A 1 92  ? -17.14565 -56.51267 9.45495   1.000 32.73534 ? 92  ASP A O    1 
ATOM   1410 C CB   . ASP A 1 92  ? -17.28034 -56.27367 6.55585   1.000 33.01708 ? 92  ASP A CB   1 
ATOM   1411 C CG   . ASP A 1 92  ? -15.77800 -56.27051 6.30335   1.000 38.36936 ? 92  ASP A CG   1 
ATOM   1412 O OD1  . ASP A 1 92  ? -15.06563 -55.38876 6.82683   1.000 34.86018 ? 92  ASP A OD1  1 
ATOM   1413 O OD2  . ASP A 1 92  ? -15.31240 -57.16572 5.56270   1.000 39.60124 ? 92  ASP A OD2  1 
ATOM   1414 H H    . ASP A 1 92  ? -16.88473 -53.76976 6.48451   1.000 34.61226 ? 92  ASP A H    1 
ATOM   1415 H HA   . ASP A 1 92  ? -18.69243 -55.32143 7.69493   1.000 36.75896 ? 92  ASP A HA   1 
ATOM   1416 H HB2  . ASP A 1 92  ? -17.52059 -57.14701 6.90293   1.000 39.67078 ? 92  ASP A HB2  1 
ATOM   1417 H HB3  . ASP A 1 92  ? -17.72378 -56.12062 5.70683   1.000 39.67078 ? 92  ASP A HB3  1 
ATOM   1418 N N    . THR A 1 93  ? -16.34737 -54.40850 9.41824   1.000 29.01107 ? 93  THR A N    1 
ATOM   1419 C CA   . THR A 1 93  ? -15.63083 -54.49745 10.68090  1.000 28.57054 ? 93  THR A CA   1 
ATOM   1420 C C    . THR A 1 93  ? -16.10530 -53.38318 11.60208  1.000 27.75580 ? 93  THR A C    1 
ATOM   1421 O O    . THR A 1 93  ? -16.08280 -52.21026 11.21722  1.000 27.44817 ? 93  THR A O    1 
ATOM   1422 C CB   . THR A 1 93  ? -14.11726 -54.37193 10.46518  1.000 34.09360 ? 93  THR A CB   1 
ATOM   1423 O OG1  . THR A 1 93  ? -13.69442 -55.30638 9.46597   1.000 39.88030 ? 93  THR A OG1  1 
ATOM   1424 C CG2  . THR A 1 93  ? -13.35464 -54.62756 11.76328  1.000 35.02989 ? 93  THR A CG2  1 
ATOM   1425 H H    . THR A 1 93  ? -16.27758 -53.63675 9.04523   1.000 34.86358 ? 93  THR A H    1 
ATOM   1426 H HA   . THR A 1 93  ? -15.81802 -55.35316 11.09757  1.000 34.33493 ? 93  THR A HA   1 
ATOM   1427 H HB   . THR A 1 93  ? -13.91044 -53.47076 10.17191  1.000 40.96261 ? 93  THR A HB   1 
ATOM   1428 H HG1  . THR A 1 93  ? -12.94491 -55.08117 9.16082   1.000 47.90665 ? 93  THR A HG1  1 
ATOM   1429 H HG21 . THR A 1 93  ? -13.80272 -54.18870 12.50323  1.000 42.08616 ? 93  THR A HG21 1 
ATOM   1430 H HG22 . THR A 1 93  ? -13.31242 -55.58017 11.94117  1.000 42.08616 ? 93  THR A HG22 1 
ATOM   1431 H HG23 . THR A 1 93  ? -12.45174 -54.28041 11.69148  1.000 42.08616 ? 93  THR A HG23 1 
ATOM   1432 N N    . ALA A 1 94  ? -16.53194 -53.75475 12.81181  1.000 26.30928 ? 94  ALA A N    1 
ATOM   1433 C CA   . ALA A 1 94  ? -16.78446 -52.77956 13.86490  1.000 26.86546 ? 94  ALA A CA   1 
ATOM   1434 C C    . ALA A 1 94  ? -15.46195 -52.22050 14.36828  1.000 28.90186 ? 94  ALA A C    1 
ATOM   1435 O O    . ALA A 1 94  ? -14.52135 -52.97410 14.63214  1.000 28.55895 ? 94  ALA A O    1 
ATOM   1436 C CB   . ALA A 1 94  ? -17.54995 -53.42759 15.01811  1.000 29.66421 ? 94  ALA A CB   1 
ATOM   1437 H H    . ALA A 1 94  ? -16.68229 -54.56861 13.04552  1.000 31.62143 ? 94  ALA A H    1 
ATOM   1438 H HA   . ALA A 1 94  ? -17.32382 -52.05343 13.51458  1.000 32.28884 ? 94  ALA A HA   1 
ATOM   1439 H HB1  . ALA A 1 94  ? -17.71092 -52.76115 15.70428  1.000 35.64734 ? 94  ALA A HB1  1 
ATOM   1440 H HB2  . ALA A 1 94  ? -18.39418 -53.76923 14.68427  1.000 35.64734 ? 94  ALA A HB2  1 
ATOM   1441 H HB3  . ALA A 1 94  ? -17.01925 -54.15412 15.38064  1.000 35.64734 ? 94  ALA A HB3  1 
ATOM   1442 N N    . ASN A 1 95  ? -15.37333 -50.91098 14.49462  1.000 25.83364 ? 95  ASN A N    1 
ATOM   1443 C CA   . ASN A 1 95  ? -14.13424 -50.32090 14.98140  1.000 25.62139 ? 95  ASN A CA   1 
ATOM   1444 C C    . ASN A 1 95  ? -13.83653 -50.83365 16.39323  1.000 25.98714 ? 95  ASN A C    1 
ATOM   1445 O O    . ASN A 1 95  ? -14.60783 -50.53203 17.32018  1.000 26.65166 ? 95  ASN A O    1 
ATOM   1446 C CB   . ASN A 1 95  ? -14.22036 -48.79802 14.96942  1.000 24.05370 ? 95  ASN A CB   1 
ATOM   1447 C CG   . ASN A 1 95  ? -12.91849 -48.13115 15.41031  1.000 26.85067 ? 95  ASN A CG   1 
ATOM   1448 O OD1  . ASN A 1 95  ? -11.95454 -48.79993 15.77813  1.000 26.78179 ? 95  ASN A OD1  1 
ATOM   1449 N ND2  . ASN A 1 95  ? -12.88424 -46.80841 15.34947  1.000 25.90417 ? 95  ASN A ND2  1 
ATOM   1450 H H    . ASN A 1 95  ? -15.99976 -50.35127 14.31048  1.000 31.05065 ? 95  ASN A H    1 
ATOM   1451 H HA   . ASN A 1 95  ? -13.40376 -50.57719 14.39693  1.000 30.79595 ? 95  ASN A HA   1 
ATOM   1452 H HB2  . ASN A 1 95  ? -14.42057 -48.49948 14.06848  1.000 28.91474 ? 95  ASN A HB2  1 
ATOM   1453 H HB3  . ASN A 1 95  ? -14.92269 -48.51601 15.57613  1.000 28.91474 ? 95  ASN A HB3  1 
ATOM   1454 H HD21 . ASN A 1 95  ? -12.17410 -46.38529 15.58667  1.000 31.13529 ? 95  ASN A HD21 1 
ATOM   1455 H HD22 . ASN A 1 95  ? -13.57215 -46.37273 15.07276  1.000 31.13529 ? 95  ASN A HD22 1 
ATOM   1456 N N    . PRO A 1 96  ? -12.75074 -51.58204 16.60797  1.000 27.66628 ? 96  PRO A N    1 
ATOM   1457 C CA   . PRO A 1 96  ? -12.48200 -52.10346 17.95809  1.000 29.33000 ? 96  PRO A CA   1 
ATOM   1458 C C    . PRO A 1 96  ? -12.13133 -51.02462 18.96173  1.000 30.40499 ? 96  PRO A C    1 
ATOM   1459 O O    . PRO A 1 96  ? -12.14072 -51.30489 20.16729  1.000 30.74863 ? 96  PRO A O    1 
ATOM   1460 C CB   . PRO A 1 96  ? -11.30364 -53.05993 17.74126  1.000 29.24788 ? 96  PRO A CB   1 
ATOM   1461 C CG   . PRO A 1 96  ? -10.59909 -52.51671 16.55485  1.000 30.51778 ? 96  PRO A CG   1 
ATOM   1462 C CD   . PRO A 1 96  ? -11.66930 -51.91614 15.66288  1.000 28.27457 ? 96  PRO A CD   1 
ATOM   1463 H HA   . PRO A 1 96  ? -13.24422 -52.60967 18.28006  1.000 35.24629 ? 96  PRO A HA   1 
ATOM   1464 H HB2  . PRO A 1 96  ? -10.72660 -53.05841 18.52095  1.000 35.14775 ? 96  PRO A HB2  1 
ATOM   1465 H HB3  . PRO A 1 96  ? -11.63080 -53.95734 17.57240  1.000 35.14775 ? 96  PRO A HB3  1 
ATOM   1466 H HG2  . PRO A 1 96  ? -9.96638  -51.83696 16.83505  1.000 36.67162 ? 96  PRO A HG2  1 
ATOM   1467 H HG3  . PRO A 1 96  ? -10.13415 -53.23371 16.09590  1.000 36.67162 ? 96  PRO A HG3  1 
ATOM   1468 H HD2  . PRO A 1 96  ? -11.34082 -51.11899 15.21841  1.000 33.97978 ? 96  PRO A HD2  1 
ATOM   1469 H HD3  . PRO A 1 96  ? -11.97269 -52.56146 15.00531  1.000 33.97978 ? 96  PRO A HD3  1 
ATOM   1470 N N    . LYS A 1 97  ? -11.82979 -49.81302 18.49576  1.000 28.96509 ? 97  LYS A N    1 
ATOM   1471 C CA   . LYS A 1 97  ? -11.51712 -48.67602 19.34460  1.000 28.39360 ? 97  LYS A CA   1 
ATOM   1472 C C    . LYS A 1 97  ? -12.70457 -47.74022 19.54317  1.000 29.54998 ? 97  LYS A C    1 
ATOM   1473 O O    . LYS A 1 97  ? -12.52541 -46.63842 20.07184  1.000 31.02330 ? 97  LYS A O    1 
ATOM   1474 C CB   . LYS A 1 97  ? -10.34791 -47.88745 18.74676  1.000 30.55031 ? 97  LYS A CB   1 
ATOM   1475 C CG   . LYS A 1 97  ? -9.05105  -48.66659 18.62572  1.000 35.22433 ? 97  LYS A CG   1 
ATOM   1476 C CD   . LYS A 1 97  ? -7.97950  -47.82907 17.93738  1.000 43.03619 ? 97  LYS A CD   1 
ATOM   1477 C CE   . LYS A 1 97  ? -6.63936  -48.54152 17.92489  1.000 49.48470 ? 97  LYS A CE   1 
ATOM   1478 N NZ   . LYS A 1 97  ? -5.70680  -47.94229 16.93611  1.000 49.36201 ? 97  LYS A NZ   1 
ATOM   1479 H H    . LYS A 1 97  ? -11.79995 -49.62222 17.65772  1.000 34.80840 ? 97  LYS A H    1 
ATOM   1480 H HA   . LYS A 1 97  ? -11.25291 -49.01204 20.21534  1.000 34.12261 ? 97  LYS A HA   1 
ATOM   1481 H HB2  . LYS A 1 97  ? -10.59707 -47.59541 17.85595  1.000 36.71067 ? 97  LYS A HB2  1 
ATOM   1482 H HB3  . LYS A 1 97  ? -10.17454 -47.11824 19.31170  1.000 36.71067 ? 97  LYS A HB3  1 
ATOM   1483 H HG2  . LYS A 1 97  ? -8.73335  -48.90649 19.51027  1.000 42.31949 ? 97  LYS A HG2  1 
ATOM   1484 H HG3  . LYS A 1 97  ? -9.20182  -49.46703 18.09898  1.000 42.31949 ? 97  LYS A HG3  1 
ATOM   1485 H HD2  . LYS A 1 97  ? -8.24378  -47.66064 17.01940  1.000 51.69372 ? 97  LYS A HD2  1 
ATOM   1486 H HD3  . LYS A 1 97  ? -7.87401  -46.98950 18.41161  1.000 51.69372 ? 97  LYS A HD3  1 
ATOM   1487 H HE2  . LYS A 1 97  ? -6.23383  -48.47625 18.80363  1.000 59.43193 ? 97  LYS A HE2  1 
ATOM   1488 H HE3  . LYS A 1 97  ? -6.77409  -49.47297 17.69004  1.000 59.43193 ? 97  LYS A HE3  1 
ATOM   1489 H HZ1  . LYS A 1 97  ? -5.97886  -48.12844 16.10941  1.000 59.28471 ? 97  LYS A HZ1  1 
ATOM   1490 H HZ2  . LYS A 1 97  ? -5.68023  -47.05870 17.03936  1.000 59.28471 ? 97  LYS A HZ2  1 
ATOM   1491 H HZ3  . LYS A 1 97  ? -4.88797  -48.27134 17.05168  1.000 59.28471 ? 97  LYS A HZ3  1 
ATOM   1492 N N    . THR A 1 98  ? -13.89522 -48.13633 19.13257  1.000 27.20202 ? 98  THR A N    1 
ATOM   1493 C CA   . THR A 1 98  ? -15.05839 -47.28568 19.35247  1.000 26.45855 ? 98  THR A CA   1 
ATOM   1494 C C    . THR A 1 98  ? -15.17856 -46.94523 20.83841  1.000 30.73575 ? 98  THR A C    1 
ATOM   1495 O O    . THR A 1 98  ? -15.29636 -47.86184 21.66847  1.000 30.99681 ? 98  THR A O    1 
ATOM   1496 C CB   . THR A 1 98  ? -16.33120 -47.96638 18.86156  1.000 26.77695 ? 98  THR A CB   1 
ATOM   1497 O OG1  . THR A 1 98  ? -16.15344 -48.41114 17.51102  1.000 27.13909 ? 98  THR A OG1  1 
ATOM   1498 C CG2  . THR A 1 98  ? -17.49295 -46.99086 18.90774  1.000 26.97021 ? 98  THR A CG2  1 
ATOM   1499 H H    . THR A 1 98  ? -14.05755 -48.87924 18.73090  1.000 32.69271 ? 98  THR A H    1 
ATOM   1500 H HA   . THR A 1 98  ? -14.95044 -46.46390 18.84856  1.000 31.80055 ? 98  THR A HA   1 
ATOM   1501 H HB   . THR A 1 98  ? -16.53165 -48.72706 19.42909  1.000 32.18263 ? 98  THR A HB   1 
ATOM   1502 H HG1  . THR A 1 98  ? -16.77383 -48.93556 17.29724  1.000 32.61720 ? 98  THR A HG1  1 
ATOM   1503 H HG21 . THR A 1 98  ? -18.33324 -47.47324 18.86167  1.000 32.41455 ? 98  THR A HG21 1 
ATOM   1504 H HG22 . THR A 1 98  ? -17.46666 -46.48250 19.73344  1.000 32.41455 ? 98  THR A HG22 1 
ATOM   1505 H HG23 . THR A 1 98  ? -17.44079 -46.37713 18.15841  1.000 32.41455 ? 98  THR A HG23 1 
ATOM   1506 N N    . PRO A 1 99  ? -15.13978 -45.66703 21.21213  1.000 30.48188 ? 99  PRO A N    1 
ATOM   1507 C CA   . PRO A 1 99  ? -15.41884 -45.27631 22.59963  1.000 30.69903 ? 99  PRO A CA   1 
ATOM   1508 C C    . PRO A 1 99  ? -16.92211 -45.23015 22.84716  1.000 31.07770 ? 99  PRO A C    1 
ATOM   1509 O O    . PRO A 1 99  ? -17.72816 -45.24429 21.91781  1.000 30.17173 ? 99  PRO A O    1 
ATOM   1510 C CB   . PRO A 1 99  ? -14.81675 -43.86949 22.68522  1.000 30.49365 ? 99  PRO A CB   1 
ATOM   1511 C CG   . PRO A 1 99  ? -15.09891 -43.31373 21.31790  1.000 29.96608 ? 99  PRO A CG   1 
ATOM   1512 C CD   . PRO A 1 99  ? -14.85429 -44.48974 20.37020  1.000 29.66719 ? 99  PRO A CD   1 
ATOM   1513 H HA   . PRO A 1 99  ? -14.98546 -45.86737 23.23502  1.000 36.88912 ? 99  PRO A HA   1 
ATOM   1514 H HB2  . PRO A 1 99  ? -15.25667 -43.35234 23.37799  1.000 36.64267 ? 99  PRO A HB2  1 
ATOM   1515 H HB3  . PRO A 1 99  ? -13.86401 -43.91693 22.86112  1.000 36.64267 ? 99  PRO A HB3  1 
ATOM   1516 H HG2  . PRO A 1 99  ? -16.01836 -43.00914 21.26558  1.000 36.00959 ? 99  PRO A HG2  1 
ATOM   1517 H HG3  . PRO A 1 99  ? -14.49476 -42.57956 21.12578  1.000 36.00959 ? 99  PRO A HG3  1 
ATOM   1518 H HD2  . PRO A 1 99  ? -15.45750 -44.45321 19.61144  1.000 35.65092 ? 99  PRO A HD2  1 
ATOM   1519 H HD3  . PRO A 1 99  ? -13.93443 -44.49994 20.06255  1.000 35.65092 ? 99  PRO A HD3  1 
ATOM   1520 N N    . LYS A 1 100 ? -17.29064 -45.17338 24.12658  1.000 32.46568 ? 100 LYS A N    1 
ATOM   1521 C CA   . LYS A 1 100 ? -18.62866 -44.71306 24.46939  1.000 32.76872 ? 100 LYS A CA   1 
ATOM   1522 C C    . LYS A 1 100 ? -18.84308 -43.36458 23.79321  1.000 30.99810 ? 100 LYS A C    1 
ATOM   1523 O O    . LYS A 1 100 ? -17.98863 -42.47823 23.89049  1.000 29.85293 ? 100 LYS A O    1 
ATOM   1524 C CB   . LYS A 1 100 ? -18.80457 -44.55201 25.97736  1.000 37.38744 ? 100 LYS A CB   1 
ATOM   1525 C CG   . LYS A 1 100 ? -18.84370 -45.82824 26.80296  1.000 48.34698 ? 100 LYS A CG   1 
ATOM   1526 C CD   . LYS A 1 100 ? -19.38972 -45.50646 28.19856  1.000 61.12662 ? 100 LYS A CD   1 
ATOM   1527 C CE   . LYS A 1 100 ? -19.27359 -46.67151 29.16998  1.000 62.89252 ? 100 LYS A CE   1 
ATOM   1528 N NZ   . LYS A 1 100 ? -17.86107 -46.98115 29.52694  1.000 65.77208 ? 100 LYS A NZ   1 
ATOM   1529 H H    . LYS A 1 100 ? -16.79551 -45.39073 24.79532  1.000 39.00910 ? 100 LYS A H    1 
ATOM   1530 H HA   . LYS A 1 100 ? -19.28317 -45.36753 24.17926  1.000 39.37276 ? 100 LYS A HA   1 
ATOM   1531 H HB2  . LYS A 1 100 ? -18.06394 -44.02174 26.31081  1.000 44.91522 ? 100 LYS A HB2  1 
ATOM   1532 H HB3  . LYS A 1 100 ? -19.64182 -44.08787 26.13381  1.000 44.91522 ? 100 LYS A HB3  1 
ATOM   1533 H HG2  . LYS A 1 100 ? -19.42593 -46.47811 26.37920  1.000 58.06667 ? 100 LYS A HG2  1 
ATOM   1534 H HG3  . LYS A 1 100 ? -17.94891 -46.19221 26.89117  1.000 58.06667 ? 100 LYS A HG3  1 
ATOM   1535 H HD2  . LYS A 1 100 ? -18.89143 -44.76042 28.56738  1.000 73.40223 ? 100 LYS A HD2  1 
ATOM   1536 H HD3  . LYS A 1 100 ? -20.32840 -45.27375 28.12352  1.000 73.40223 ? 100 LYS A HD3  1 
ATOM   1537 H HE2  . LYS A 1 100 ? -19.74844 -46.45158 29.98671  1.000 75.52131 ? 100 LYS A HE2  1 
ATOM   1538 H HE3  . LYS A 1 100 ? -19.66100 -47.46258 28.76374  1.000 75.52131 ? 100 LYS A HE3  1 
ATOM   1539 H HZ1  . LYS A 1 100 ? -17.83691 -47.61218 30.15409  1.000 78.97679 ? 100 LYS A HZ1  1 
ATOM   1540 H HZ2  . LYS A 1 100 ? -17.42209 -47.27061 28.80889  1.000 78.97679 ? 100 LYS A HZ2  1 
ATOM   1541 H HZ3  . LYS A 1 100 ? -17.45821 -46.25050 29.83670  1.000 78.97679 ? 100 LYS A HZ3  1 
ATOM   1542 N N    . TYR A 1 101 ? -19.97429 -43.19533 23.11419  1.000 29.39725 ? 101 TYR A N    1 
ATOM   1543 C CA   . TYR A 1 101 ? -20.18857 -41.94436 22.40201  1.000 28.49106 ? 101 TYR A CA   1 
ATOM   1544 C C    . TYR A 1 101 ? -21.67266 -41.64145 22.26316  1.000 28.26929 ? 101 TYR A C    1 
ATOM   1545 O O    . TYR A 1 101 ? -22.53004 -42.52496 22.33942  1.000 26.14334 ? 101 TYR A O    1 
ATOM   1546 C CB   . TYR A 1 101 ? -19.54150 -41.96096 21.00637  1.000 25.91884 ? 101 TYR A CB   1 
ATOM   1547 C CG   . TYR A 1 101 ? -20.28074 -42.82326 20.00601  1.000 25.82671 ? 101 TYR A CG   1 
ATOM   1548 C CD1  . TYR A 1 101 ? -21.31871 -42.30699 19.24008  1.000 25.05532 ? 101 TYR A CD1  1 
ATOM   1549 C CD2  . TYR A 1 101 ? -19.94903 -44.15817 19.83666  1.000 26.27025 ? 101 TYR A CD2  1 
ATOM   1550 C CE1  . TYR A 1 101 ? -22.00293 -43.09839 18.34123  1.000 26.37219 ? 101 TYR A CE1  1 
ATOM   1551 C CE2  . TYR A 1 101 ? -20.62043 -44.95200 18.93155  1.000 26.73256 ? 101 TYR A CE2  1 
ATOM   1552 C CZ   . TYR A 1 101 ? -21.64236 -44.41685 18.18216  1.000 24.88841 ? 101 TYR A CZ   1 
ATOM   1553 O OH   . TYR A 1 101 ? -22.31428 -45.20942 17.28373  1.000 28.00989 ? 101 TYR A OH   1 
ATOM   1554 H H    . TYR A 1 101 ? -20.60993 -43.77148 23.05400  1.000 35.32699 ? 101 TYR A H    1 
ATOM   1555 H HA   . TYR A 1 101 ? -19.79184 -41.23829 22.93583  1.000 34.23956 ? 101 TYR A HA   1 
ATOM   1556 H HB2  . TYR A 1 101 ? -19.52210 -41.05506 20.66015  1.000 31.15290 ? 101 TYR A HB2  1 
ATOM   1557 H HB3  . TYR A 1 101 ? -18.63817 -42.30554 21.08485  1.000 31.15290 ? 101 TYR A HB3  1 
ATOM   1558 H HD1  . TYR A 1 101 ? -21.55609 -41.41283 19.33508  1.000 30.11667 ? 101 TYR A HD1  1 
ATOM   1559 H HD2  . TYR A 1 101 ? -19.26072 -44.52519 20.34304  1.000 31.57459 ? 101 TYR A HD2  1 
ATOM   1560 H HE1  . TYR A 1 101 ? -22.70453 -42.74271 17.84510  1.000 31.69692 ? 101 TYR A HE1  1 
ATOM   1561 H HE2  . TYR A 1 101 ? -20.38357 -45.84535 18.82801  1.000 32.12937 ? 101 TYR A HE2  1 
ATOM   1562 H HH   . TYR A 1 101 ? -21.95194 -45.96604 17.24096  1.000 33.66215 ? 101 TYR A HH   1 
ATOM   1563 N N    . LYS A 1 102 ? -21.94562 -40.35283 22.05804  1.000 27.03996 ? 102 LYS A N    1 
ATOM   1564 C CA   . LYS A 1 102 ? -23.25051 -39.81039 21.72065  1.000 28.90597 ? 102 LYS A CA   1 
ATOM   1565 C C    . LYS A 1 102 ? -23.05070 -38.86830 20.54098  1.000 26.36961 ? 102 LYS A C    1 
ATOM   1566 O O    . LYS A 1 102 ? -21.95520 -38.33090 20.35042  1.000 24.93854 ? 102 LYS A O    1 
ATOM   1567 C CB   . LYS A 1 102 ? -23.87088 -39.01133 22.87979  1.000 31.69402 ? 102 LYS A CB   1 
ATOM   1568 C CG   . LYS A 1 102 ? -24.34949 -39.81483 24.06740  1.000 39.97917 ? 102 LYS A CG   1 
ATOM   1569 C CD   . LYS A 1 102 ? -24.80541 -38.90963 25.22479  1.000 47.93580 ? 102 LYS A CD   1 
ATOM   1570 C CE   . LYS A 1 102 ? -25.29631 -39.74967 26.41189  1.000 61.98859 ? 102 LYS A CE   1 
ATOM   1571 N NZ   . LYS A 1 102 ? -25.83148 -38.95062 27.55800  1.000 63.71450 ? 102 LYS A NZ   1 
ATOM   1572 H H    . LYS A 1 102 ? -21.34841 -39.73650 22.11347  1.000 32.49825 ? 102 LYS A H    1 
ATOM   1573 H HA   . LYS A 1 102 ? -23.85925 -40.53149 21.49628  1.000 34.73746 ? 102 LYS A HA   1 
ATOM   1574 H HB2  . LYS A 1 102 ? -23.20393 -38.38788 23.20750  1.000 38.08312 ? 102 LYS A HB2  1 
ATOM   1575 H HB3  . LYS A 1 102 ? -24.63750 -38.52663 22.53590  1.000 38.08312 ? 102 LYS A HB3  1 
ATOM   1576 H HG2  . LYS A 1 102 ? -25.10129 -40.36584 23.79891  1.000 48.02530 ? 102 LYS A HG2  1 
ATOM   1577 H HG3  . LYS A 1 102 ? -23.62521 -40.37502 24.38756  1.000 48.02530 ? 102 LYS A HG3  1 
ATOM   1578 H HD2  . LYS A 1 102 ? -24.06098 -38.36301 25.52131  1.000 57.57324 ? 102 LYS A HD2  1 
ATOM   1579 H HD3  . LYS A 1 102 ? -25.53422 -38.34363 24.92581  1.000 57.57324 ? 102 LYS A HD3  1 
ATOM   1580 H HE2  . LYS A 1 102 ? -26.00772 -40.33331 26.10504  1.000 74.43659 ? 102 LYS A HE2  1 
ATOM   1581 H HE3  . LYS A 1 102 ? -24.55425 -40.27804 26.74519  1.000 74.43659 ? 102 LYS A HE3  1 
ATOM   1582 H HZ1  . LYS A 1 102 ? -26.04972 -39.49129 28.23041  1.000 76.50769 ? 102 LYS A HZ1  1 
ATOM   1583 H HZ2  . LYS A 1 102 ? -25.21599 -38.37291 27.83999  1.000 76.50769 ? 102 LYS A HZ2  1 
ATOM   1584 H HZ3  . LYS A 1 102 ? -26.55538 -38.49994 27.30313  1.000 76.50769 ? 102 LYS A HZ3  1 
ATOM   1585 N N    . PHE A 1 103 ? -24.10772 -38.64444 19.76125  1.000 25.84205 ? 103 PHE A N    1 
ATOM   1586 C CA   . PHE A 1 103 ? -24.15762 -37.51728 18.83565  1.000 24.91838 ? 103 PHE A CA   1 
ATOM   1587 C C    . PHE A 1 103 ? -25.02045 -36.42938 19.46681  1.000 27.37303 ? 103 PHE A C    1 
ATOM   1588 O O    . PHE A 1 103 ? -26.13462 -36.70714 19.92204  1.000 28.40079 ? 103 PHE A O    1 
ATOM   1589 C CB   . PHE A 1 103 ? -24.75850 -37.86800 17.47507  1.000 23.35587 ? 103 PHE A CB   1 
ATOM   1590 C CG   . PHE A 1 103 ? -23.95019 -38.83570 16.66039  1.000 23.82519 ? 103 PHE A CG   1 
ATOM   1591 C CD1  . PHE A 1 103 ? -22.62183 -39.10687 16.94105  1.000 23.44539 ? 103 PHE A CD1  1 
ATOM   1592 C CD2  . PHE A 1 103 ? -24.54321 -39.46826 15.58410  1.000 23.87327 ? 103 PHE A CD2  1 
ATOM   1593 C CE1  . PHE A 1 103 ? -21.91139 -40.00637 16.16147  1.000 24.74044 ? 103 PHE A CE1  1 
ATOM   1594 C CE2  . PHE A 1 103 ? -23.84851 -40.36000 14.81555  1.000 23.21253 ? 103 PHE A CE2  1 
ATOM   1595 C CZ   . PHE A 1 103 ? -22.53057 -40.63128 15.09740  1.000 23.56328 ? 103 PHE A CZ   1 
ATOM   1596 H H    . PHE A 1 103 ? -24.81297 -39.13651 19.75158  1.000 31.06075 ? 103 PHE A H    1 
ATOM   1597 H HA   . PHE A 1 103 ? -23.24852 -37.21613 18.68160  1.000 29.95234 ? 103 PHE A HA   1 
ATOM   1598 H HB2  . PHE A 1 103 ? -25.63197 -38.26510 17.61743  1.000 28.07733 ? 103 PHE A HB2  1 
ATOM   1599 H HB3  . PHE A 1 103 ? -24.84529 -37.05230 16.95738  1.000 28.07733 ? 103 PHE A HB3  1 
ATOM   1600 H HD1  . PHE A 1 103 ? -22.20416 -38.68351 17.65604  1.000 28.18475 ? 103 PHE A HD1  1 
ATOM   1601 H HD2  . PHE A 1 103 ? -25.43135 -39.28379 15.37898  1.000 28.69821 ? 103 PHE A HD2  1 
ATOM   1602 H HE1  . PHE A 1 103 ? -21.02009 -40.18841 16.35470  1.000 29.73882 ? 103 PHE A HE1  1 
ATOM   1603 H HE2  . PHE A 1 103 ? -24.26770 -40.78347 14.10151  1.000 27.90532 ? 103 PHE A HE2  1 
ATOM   1604 H HZ   . PHE A 1 103 ? -22.05674 -41.23490 14.57202  1.000 28.32622 ? 103 PHE A HZ   1 
ATOM   1605 N N    . VAL A 1 104 ? -24.51914 -35.20072 19.47685  1.000 25.30394 ? 104 VAL A N    1 
ATOM   1606 C CA   . VAL A 1 104 ? -25.28202 -34.09490 20.02928  1.000 27.55821 ? 104 VAL A CA   1 
ATOM   1607 C C    . VAL A 1 104 ? -25.20127 -32.89699 19.09811  1.000 28.95200 ? 104 VAL A C    1 
ATOM   1608 O O    . VAL A 1 104 ? -24.19965 -32.67326 18.41165  1.000 27.26722 ? 104 VAL A O    1 
ATOM   1609 C CB   . VAL A 1 104 ? -24.80687 -33.68950 21.44624  1.000 27.88184 ? 104 VAL A CB   1 
ATOM   1610 C CG1  . VAL A 1 104 ? -24.77261 -34.89699 22.36243  1.000 30.75917 ? 104 VAL A CG1  1 
ATOM   1611 C CG2  . VAL A 1 104 ? -23.46096 -32.98737 21.38413  1.000 31.25830 ? 104 VAL A CG2  1 
ATOM   1612 H H    . VAL A 1 104 ? -23.74444 -34.98649 19.17098  1.000 30.41502 ? 104 VAL A H    1 
ATOM   1613 H HA   . VAL A 1 104 ? -26.20831 -34.37761 20.08379  1.000 33.12015 ? 104 VAL A HA   1 
ATOM   1614 H HB   . VAL A 1 104 ? -25.43951 -33.05859 21.82388  1.000 33.50850 ? 104 VAL A HB   1 
ATOM   1615 H HG11 . VAL A 1 104 ? -25.24679 -35.62903 21.93797  1.000 36.96130 ? 104 VAL A HG11 1 
ATOM   1616 H HG12 . VAL A 1 104 ? -23.84894 -35.14809 22.51955  1.000 36.96130 ? 104 VAL A HG12 1 
ATOM   1617 H HG13 . VAL A 1 104 ? -25.20070 -34.66839 23.20230  1.000 36.96130 ? 104 VAL A HG13 1 
ATOM   1618 H HG21 . VAL A 1 104 ? -22.97252 -33.30876 20.61016  1.000 37.56025 ? 104 VAL A HG21 1 
ATOM   1619 H HG22 . VAL A 1 104 ? -23.60668 -32.03127 21.30970  1.000 37.56025 ? 104 VAL A HG22 1 
ATOM   1620 H HG23 . VAL A 1 104 ? -22.96440 -33.18424 22.19380  1.000 37.56025 ? 104 VAL A HG23 1 
ATOM   1621 N N    . ARG A 1 105 ? -26.26846 -32.12326 19.07976  1.000 27.08496 ? 105 ARG A N    1 
ATOM   1622 C CA   . ARG A 1 105 ? -26.28347 -30.84791 18.38821  1.000 26.09906 ? 105 ARG A CA   1 
ATOM   1623 C C    . ARG A 1 105 ? -26.06431 -29.78288 19.45786  1.000 28.49816 ? 105 ARG A C    1 
ATOM   1624 O O    . ARG A 1 105 ? -26.94941 -29.54230 20.29240  1.000 26.41596 ? 105 ARG A O    1 
ATOM   1625 C CB   . ARG A 1 105 ? -27.59079 -30.65963 17.62390  1.000 28.19771 ? 105 ARG A CB   1 
ATOM   1626 C CG   . ARG A 1 105 ? -27.60892 -29.43807 16.73900  1.000 27.14371 ? 105 ARG A CG   1 
ATOM   1627 C CD   . ARG A 1 105 ? -28.78595 -29.46600 15.78079  1.000 28.65128 ? 105 ARG A CD   1 
ATOM   1628 N NE   . ARG A 1 105 ? -28.84909 -28.22791 15.01426  1.000 28.17645 ? 105 ARG A NE   1 
ATOM   1629 C CZ   . ARG A 1 105 ? -28.25734 -28.02710 13.84258  1.000 27.06855 ? 105 ARG A CZ   1 
ATOM   1630 N NH1  . ARG A 1 105 ? -27.59817 -28.99252 13.22120  1.000 25.13275 ? 105 ARG A NH1  1 
ATOM   1631 N NH2  . ARG A 1 105 ? -28.32894 -26.82548 13.28044  1.000 26.18136 ? 105 ARG A NH2  1 
ATOM   1632 H H    . ARG A 1 105 ? -27.01088 -32.31796 19.46770  1.000 32.55224 ? 105 ARG A H    1 
ATOM   1633 H HA   . ARG A 1 105 ? -25.57088 -30.78858 17.73278  1.000 31.36916 ? 105 ARG A HA   1 
ATOM   1634 H HB2  . ARG A 1 105 ? -27.73658 -31.43545 17.06021  1.000 33.88754 ? 105 ARG A HB2  1 
ATOM   1635 H HB3  . ARG A 1 105 ? -28.31546 -30.57287 18.26283  1.000 33.88754 ? 105 ARG A HB3  1 
ATOM   1636 H HG2  . ARG A 1 105 ? -27.68233 -28.64294 17.28970  1.000 32.62275 ? 105 ARG A HG2  1 
ATOM   1637 H HG3  . ARG A 1 105 ? -26.79152 -29.40627 16.21770  1.000 32.62275 ? 105 ARG A HG3  1 
ATOM   1638 H HD2  . ARG A 1 105 ? -28.68484 -30.20726 15.16337  1.000 34.43182 ? 105 ARG A HD2  1 
ATOM   1639 H HD3  . ARG A 1 105 ? -29.61085 -29.56189 16.28204  1.000 34.43182 ? 105 ARG A HD3  1 
ATOM   1640 H HE   . ARG A 1 105 ? -29.30420 -27.57799 15.34606  1.000 33.86203 ? 105 ARG A HE   1 
ATOM   1641 H HH11 . ARG A 1 105 ? -27.54503 -29.77417 13.57587  1.000 30.20960 ? 105 ARG A HH11 1 
ATOM   1642 H HH12 . ARG A 1 105 ? -27.22310 -28.83800 12.46288  1.000 30.20960 ? 105 ARG A HH12 1 
ATOM   1643 H HH21 . ARG A 1 105 ? -28.75423 -26.19073 13.67519  1.000 31.46792 ? 105 ARG A HH21 1 
ATOM   1644 H HH22 . ARG A 1 105 ? -27.95001 -26.68238 12.52180  1.000 31.46792 ? 105 ARG A HH22 1 
ATOM   1645 N N    . ILE A 1 106 ? -24.86149 -29.18562 19.46014  1.000 27.40687 ? 106 ILE A N    1 
ATOM   1646 C CA   A ILE A 1 106 ? -24.52117 -28.20532 20.49890  0.500 28.48300 ? 106 ILE A CA   1 
ATOM   1647 C CA   B ILE A 1 106 ? -24.51222 -28.22240 20.47770  0.500 27.90156 ? 106 ILE A CA   1 
ATOM   1648 C C    . ILE A 1 106 ? -25.25815 -26.90644 20.23165  1.000 28.93748 ? 106 ILE A C    1 
ATOM   1649 O O    . ILE A 1 106 ? -25.65116 -26.57615 19.10766  1.000 27.64874 ? 106 ILE A O    1 
ATOM   1650 C CB   A ILE A 1 106 ? -23.00419 -27.92297 20.63640  0.500 28.48595 ? 106 ILE A CB   1 
ATOM   1651 C CB   B ILE A 1 106 ? -22.98003 -28.04081 20.43636  0.500 28.71719 ? 106 ILE A CB   1 
ATOM   1652 C CG1  A ILE A 1 106 ? -22.33617 -27.75094 19.27162  0.500 27.91632 ? 106 ILE A CG1  1 
ATOM   1653 C CG1  B ILE A 1 106 ? -22.35195 -28.00119 21.82947  0.500 29.49218 ? 106 ILE A CG1  1 
ATOM   1654 C CG2  A ILE A 1 106 ? -22.30645 -28.93579 21.55045  0.500 30.65726 ? 106 ILE A CG2  1 
ATOM   1655 C CG2  B ILE A 1 106 ? -22.60186 -26.81290 19.60603  0.500 28.15439 ? 106 ILE A CG2  1 
ATOM   1656 C CD1  A ILE A 1 106 ? -22.63658 -26.42935 18.63031  0.500 28.52925 ? 106 ILE A CD1  1 
ATOM   1657 C CD1  B ILE A 1 106 ? -20.84561 -27.78691 21.80093  0.500 28.81421 ? 106 ILE A CD1  1 
ATOM   1658 H H    . ILE A 1 106 ? -24.23755 -29.32606 18.88518  1.000 32.93854 ? 106 ILE A H    1 
ATOM   1659 H HA   . ILE A 1 106 ? -24.80693 -28.59336 21.34073  1.000 33.53217 ? 106 ILE A HA   1 
ATOM   1660 H HB   A ILE A 1 106 ? -22.90586 -27.06855 21.08495  0.500 34.23343 ? 106 ILE A HB   1 
ATOM   1661 H HB   B ILE A 1 106 ? -22.61386 -28.82650 20.00102  0.500 34.51091 ? 106 ILE A HB   1 
ATOM   1662 H HG12 A ILE A 1 106 ? -21.37476 -27.81768 19.38177  0.500 33.54987 ? 106 ILE A HG12 1 
ATOM   1663 H HG12 B ILE A 1 106 ? -22.74782 -27.27203 22.33197  0.500 35.44091 ? 106 ILE A HG12 1 
ATOM   1664 H HG13 A ILE A 1 106 ? -22.65132 -28.44973 18.67726  0.500 33.54987 ? 106 ILE A HG13 1 
ATOM   1665 H HG13 B ILE A 1 106 ? -22.52518 -28.84453 22.27632  0.500 35.44091 ? 106 ILE A HG13 1 
ATOM   1666 H HG21 A ILE A 1 106 ? -22.64524 -28.83207 22.45342  0.500 36.83900 ? 106 ILE A HG21 1 
ATOM   1667 H HG21 B ILE A 1 106 ? -23.10211 -26.82728 18.77510  0.500 33.83556 ? 106 ILE A HG21 1 
ATOM   1668 H HG22 A ILE A 1 106 ? -22.49181 -29.83184 21.22850  0.500 36.83900 ? 106 ILE A HG22 1 
ATOM   1669 H HG22 B ILE A 1 106 ? -22.81901 -26.01244 20.10905  0.500 33.83556 ? 106 ILE A HG22 1 
ATOM   1670 H HG23 A ILE A 1 106 ? -21.35092 -28.76967 21.53455  0.500 36.83900 ? 106 ILE A HG23 1 
ATOM   1671 H HG23 B ILE A 1 106 ? -21.65027 -26.83851 19.41973  0.500 33.83556 ? 106 ILE A HG23 1 
ATOM   1672 H HD11 A ILE A 1 106 ? -21.92785 -26.21385 18.00408  0.500 34.28539 ? 106 ILE A HD11 1 
ATOM   1673 H HD11 B ILE A 1 106 ? -20.45726 -28.36421 21.12506  0.500 34.62734 ? 106 ILE A HD11 1 
ATOM   1674 H HD12 A ILE A 1 106 ? -23.48405 -26.49076 18.16242  0.500 34.28539 ? 106 ILE A HD12 1 
ATOM   1675 H HD12 B ILE A 1 106 ? -20.47910 -28.00463 22.67223  0.500 34.62734 ? 106 ILE A HD12 1 
ATOM   1676 H HD13 A ILE A 1 106 ? -22.68766 -25.74839 19.31920  0.500 34.28539 ? 106 ILE A HD13 1 
ATOM   1677 H HD13 B ILE A 1 106 ? -20.66269 -26.85848 21.58773  0.500 34.62734 ? 106 ILE A HD13 1 
ATOM   1678 N N    . GLN A 1 107 ? -25.43014 -26.16493 21.26084  1.000 30.41871 ? 107 GLN A N    1 
ATOM   1679 C CA   . GLN A 1 107 ? -26.08597 -24.86650 21.18478  1.000 30.92597 ? 107 GLN A CA   1 
ATOM   1680 C C    . GLN A 1 107 ? -25.06648 -23.77243 20.89997  1.000 28.76739 ? 107 GLN A C    1 
ATOM   1681 O O    . GLN A 1 107 ? -23.89900 -23.89113 21.28540  1.000 28.61551 ? 107 GLN A O    1 
ATOM   1682 C CB   . GLN A 1 107 ? -26.79919 -24.56294 22.49847  1.000 33.54879 ? 107 GLN A CB   1 
ATOM   1683 C CG   . GLN A 1 107 ? -28.17780 -25.19861 22.62392  1.000 38.94688 ? 107 GLN A CG   1 
ATOM   1684 C CD   . GLN A 1 107 ? -29.26115 -24.38787 21.93235  1.000 46.93919 ? 107 GLN A CD   1 
ATOM   1685 O OE1  . GLN A 1 107 ? -29.55991 -23.26278 22.33326  1.000 45.33492 ? 107 GLN A OE1  1 
ATOM   1686 N NE2  . GLN A 1 107 ? -29.85345 -24.95652 20.88874  1.000 48.03821 ? 107 GLN A NE2  1 
ATOM   1687 H H    . GLN A 1 107 ? -25.17627 -26.37521 22.05516  1.000 36.55274 ? 107 GLN A H    1 
ATOM   1688 H HA   . GLN A 1 107 ? -26.74208 -24.86865 20.47036  1.000 37.16145 ? 107 GLN A HA   1 
ATOM   1689 H HB2  . GLN A 1 107 ? -26.25513 -24.89410 23.23007  1.000 40.30884 ? 107 GLN A HB2  1 
ATOM   1690 H HB3  . GLN A 1 107 ? -26.91023 -23.60244 22.57594  1.000 40.30884 ? 107 GLN A HB3  1 
ATOM   1691 H HG2  . GLN A 1 107 ? -28.15791 -26.08005 22.21950  1.000 46.78655 ? 107 GLN A HG2  1 
ATOM   1692 H HG3  . GLN A 1 107 ? -28.40926 -25.26971 23.56322  1.000 46.78655 ? 107 GLN A HG3  1 
ATOM   1693 H HE21 . GLN A 1 107 ? -29.61771 -25.74437 20.63711  1.000 57.69614 ? 107 GLN A HE21 1 
ATOM   1694 H HE22 . GLN A 1 107 ? -30.47278 -24.53696 20.46449  1.000 57.69614 ? 107 GLN A HE22 1 
ATOM   1695 N N    . PRO A 1 108 ? -25.46772 -22.68490 20.23893  1.000 28.87963 ? 108 PRO A N    1 
ATOM   1696 C CA   . PRO A 1 108 ? -24.54097 -21.55864 20.06782  1.000 29.20151 ? 108 PRO A CA   1 
ATOM   1697 C C    . PRO A 1 108 ? -24.06257 -21.02824 21.41132  1.000 26.73701 ? 108 PRO A C    1 
ATOM   1698 O O    . PRO A 1 108 ? -24.81442 -20.96089 22.38780  1.000 27.83653 ? 108 PRO A O    1 
ATOM   1699 C CB   . PRO A 1 108 ? -25.37315 -20.51975 19.30598  1.000 31.53766 ? 108 PRO A CB   1 
ATOM   1700 C CG   . PRO A 1 108 ? -26.80101 -20.92631 19.52781  1.000 31.37331 ? 108 PRO A CG   1 
ATOM   1701 C CD   . PRO A 1 108 ? -26.77639 -22.41859 19.61727  1.000 30.63745 ? 108 PRO A CD   1 
ATOM   1702 H HA   . PRO A 1 108 ? -23.77730 -21.81887 19.52930  1.000 35.09210 ? 108 PRO A HA   1 
ATOM   1703 H HB2  . PRO A 1 108 ? -25.20465 -19.63444 19.66479  1.000 37.89548 ? 108 PRO A HB2  1 
ATOM   1704 H HB3  . PRO A 1 108 ? -25.14798 -20.54383 18.36279  1.000 37.89548 ? 108 PRO A HB3  1 
ATOM   1705 H HG2  . PRO A 1 108 ? -27.13043 -20.53600 20.35246  1.000 37.69827 ? 108 PRO A HG2  1 
ATOM   1706 H HG3  . PRO A 1 108 ? -27.34671 -20.63377 18.78113  1.000 37.69827 ? 108 PRO A HG3  1 
ATOM   1707 H HD2  . PRO A 1 108 ? -27.49915 -22.74509 20.17576  1.000 36.81524 ? 108 PRO A HD2  1 
ATOM   1708 H HD3  . PRO A 1 108 ? -26.83057 -22.82037 18.73606  1.000 36.81524 ? 108 PRO A HD3  1 
ATOM   1709 N N    . GLY A 1 109 ? -22.78669 -20.66053 21.44701  1.000 23.31338 ? 109 GLY A N    1 
ATOM   1710 C CA   . GLY A 1 109 ? -22.14267 -20.24257 22.66103  1.000 24.29373 ? 109 GLY A CA   1 
ATOM   1711 C C    . GLY A 1 109 ? -21.40856 -21.34259 23.39337  1.000 27.89918 ? 109 GLY A C    1 
ATOM   1712 O O    . GLY A 1 109 ? -20.61306 -21.03924 24.28688  1.000 27.36346 ? 109 GLY A O    1 
ATOM   1713 H H    . GLY A 1 109 ? -22.27043 -20.64815 20.75931  1.000 28.02634 ? 109 GLY A H    1 
ATOM   1714 H HA2  . GLY A 1 109 ? -21.50094 -19.54649 22.44993  1.000 29.20277 ? 109 GLY A HA2  1 
ATOM   1715 H HA3  . GLY A 1 109 ? -22.81352 -19.88200 23.26174  1.000 29.20277 ? 109 GLY A HA3  1 
ATOM   1716 N N    . GLN A 1 110 ? -21.66483 -22.60288 23.06406  1.000 26.08467 ? 110 GLN A N    1 
ATOM   1717 C CA   . GLN A 1 110 ? -20.93361 -23.70831 23.66354  1.000 27.18765 ? 110 GLN A CA   1 
ATOM   1718 C C    . GLN A 1 110 ? -19.64709 -23.95833 22.89265  1.000 24.95357 ? 110 GLN A C    1 
ATOM   1719 O O    . GLN A 1 110 ? -19.49970 -23.57207 21.72811  1.000 24.27369 ? 110 GLN A O    1 
ATOM   1720 C CB   . GLN A 1 110 ? -21.78225 -24.97231 23.69609  1.000 27.89399 ? 110 GLN A CB   1 
ATOM   1721 C CG   . GLN A 1 110 ? -23.03214 -24.81247 24.52594  1.000 31.10057 ? 110 GLN A CG   1 
ATOM   1722 C CD   . GLN A 1 110 ? -22.72695 -24.49958 25.97774  1.000 35.79516 ? 110 GLN A CD   1 
ATOM   1723 O OE1  . GLN A 1 110 ? -22.00654 -25.24098 26.64831  1.000 36.28045 ? 110 GLN A OE1  1 
ATOM   1724 N NE2  . GLN A 1 110 ? -23.27025 -23.39416 26.46985  1.000 35.88233 ? 110 GLN A NE2  1 
ATOM   1725 H H    . GLN A 1 110 ? -22.26091 -22.84355 22.49277  1.000 31.35190 ? 110 GLN A H    1 
ATOM   1726 H HA   . GLN A 1 110 ? -20.70787 -23.48609 24.58036  1.000 32.67547 ? 110 GLN A HA   1 
ATOM   1727 H HB2  . GLN A 1 110 ? -22.04890 -25.19726 22.79100  1.000 33.52308 ? 110 GLN A HB2  1 
ATOM   1728 H HB3  . GLN A 1 110 ? -21.25873 -25.69465 24.07695  1.000 33.52308 ? 110 GLN A HB3  1 
ATOM   1729 H HG2  . GLN A 1 110 ? -23.56128 -24.08378 24.16550  1.000 37.37097 ? 110 GLN A HG2  1 
ATOM   1730 H HG3  . GLN A 1 110 ? -23.54054 -25.63802 24.49611  1.000 37.37097 ? 110 GLN A HG3  1 
ATOM   1731 H HE21 . GLN A 1 110 ? -23.76527 -22.89914 25.97035  1.000 43.10909 ? 110 GLN A HE21 1 
ATOM   1732 H HE22 . GLN A 1 110 ? -23.12748 -23.17245 27.28842  1.000 43.10909 ? 110 GLN A HE22 1 
ATOM   1733 N N    . THR A 1 111 ? -18.70356 -24.60039 23.56729  1.000 25.12340 ? 111 THR A N    1 
ATOM   1734 C CA   . THR A 1 111 ? -17.38437 -24.86761 23.02022  1.000 25.02213 ? 111 THR A CA   1 
ATOM   1735 C C    . THR A 1 111 ? -17.21200 -26.35601 22.75922  1.000 24.23275 ? 111 THR A C    1 
ATOM   1736 O O    . THR A 1 111 ? -17.98567 -27.19580 23.22723  1.000 25.67545 ? 111 THR A O    1 
ATOM   1737 C CB   . THR A 1 111 ? -16.28884 -24.37343 23.97428  1.000 27.35452 ? 111 THR A CB   1 
ATOM   1738 O OG1  . THR A 1 111 ? -16.46488 -24.95821 25.27309  1.000 27.75437 ? 111 THR A OG1  1 
ATOM   1739 C CG2  . THR A 1 111 ? -16.34012 -22.85680 24.08088  1.000 26.73769 ? 111 THR A CG2  1 
ATOM   1740 H H    . THR A 1 111 ? -18.80835 -24.89906 24.36693  1.000 30.19837 ? 111 THR A H    1 
ATOM   1741 H HA   . THR A 1 111 ? -17.28652 -24.40092 22.17551  1.000 30.07685 ? 111 THR A HA   1 
ATOM   1742 H HB   . THR A 1 111 ? -15.41798 -24.63188 23.63412  1.000 32.87572 ? 111 THR A HB   1 
ATOM   1743 H HG1  . THR A 1 111 ? -16.36845 -25.79147 25.22846  1.000 33.35553 ? 111 THR A HG1  1 
ATOM   1744 H HG21 . THR A 1 111 ? -16.55911 -22.59527 24.98893  1.000 32.13552 ? 111 THR A HG21 1 
ATOM   1745 H HG22 . THR A 1 111 ? -15.47927 -22.47822 23.84318  1.000 32.13552 ? 111 THR A HG22 1 
ATOM   1746 H HG23 . THR A 1 111 ? -17.01554 -22.50466 23.48030  1.000 32.13552 ? 111 THR A HG23 1 
ATOM   1747 N N    . PHE A 1 112 ? -16.17898 -26.66150 21.97975  1.000 23.09874 ? 112 PHE A N    1 
ATOM   1748 C CA   . PHE A 1 112 ? -15.79977 -28.04269 21.72626  1.000 23.44631 ? 112 PHE A CA   1 
ATOM   1749 C C    . PHE A 1 112 ? -14.37703 -28.07572 21.19702  1.000 22.19543 ? 112 PHE A C    1 
ATOM   1750 O O    . PHE A 1 112 ? -13.81071 -27.05592 20.80055  1.000 22.13406 ? 112 PHE A O    1 
ATOM   1751 C CB   . PHE A 1 112 ? -16.75476 -28.71784 20.74603  1.000 22.22558 ? 112 PHE A CB   1 
ATOM   1752 C CG   . PHE A 1 112 ? -16.91613 -28.00020 19.42355  1.000 22.13759 ? 112 PHE A CG   1 
ATOM   1753 C CD1  . PHE A 1 112 ? -17.89771 -27.03908 19.25810  1.000 23.49563 ? 112 PHE A CD1  1 
ATOM   1754 C CD2  . PHE A 1 112 ? -16.12675 -28.33777 18.33500  1.000 19.66514 ? 112 PHE A CD2  1 
ATOM   1755 C CE1  . PHE A 1 112 ? -18.06947 -26.40672 18.03889  1.000 23.44622 ? 112 PHE A CE1  1 
ATOM   1756 C CE2  . PHE A 1 112 ? -16.29850 -27.72093 17.11464  1.000 19.79057 ? 112 PHE A CE2  1 
ATOM   1757 C CZ   . PHE A 1 112 ? -17.26795 -26.75112 16.96506  1.000 21.37626 ? 112 PHE A CZ   1 
ATOM   1758 H H    . PHE A 1 112 ? -15.68072 -26.08221 21.58510  1.000 27.76878 ? 112 PHE A H    1 
ATOM   1759 H HA   . PHE A 1 112 ? -15.82448 -28.52866 22.56538  1.000 28.18586 ? 112 PHE A HA   1 
ATOM   1760 H HB2  . PHE A 1 112 ? -16.42200 -29.60892 20.55590  1.000 26.72098 ? 112 PHE A HB2  1 
ATOM   1761 H HB3  . PHE A 1 112 ? -17.63141 -28.77191 21.15768  1.000 26.72098 ? 112 PHE A HB3  1 
ATOM   1762 H HD1  . PHE A 1 112 ? -18.44795 -26.81558 19.97377  1.000 28.24505 ? 112 PHE A HD1  1 
ATOM   1763 H HD2  . PHE A 1 112 ? -15.47119 -28.99058 18.42977  1.000 23.64846 ? 112 PHE A HD2  1 
ATOM   1764 H HE1  . PHE A 1 112 ? -18.72238 -25.75161 17.94171  1.000 28.18575 ? 112 PHE A HE1  1 
ATOM   1765 H HE2  . PHE A 1 112 ? -15.76171 -27.95812 16.39318  1.000 23.79897 ? 112 PHE A HE2  1 
ATOM   1766 H HZ   . PHE A 1 112 ? -17.38255 -26.32961 16.14403  1.000 25.70180 ? 112 PHE A HZ   1 
ATOM   1767 N N    . SER A 1 113 ? -13.80104 -29.27281 21.20672  1.000 21.23108 ? 113 SER A N    1 
ATOM   1768 C CA   . SER A 1 113 ? -12.46019 -29.49327 20.69013  1.000 21.78118 ? 113 SER A CA   1 
ATOM   1769 C C    . SER A 1 113 ? -12.54444 -29.98169 19.25578  1.000 22.47709 ? 113 SER A C    1 
ATOM   1770 O O    . SER A 1 113 ? -13.34734 -30.86446 18.94769  1.000 21.67708 ? 113 SER A O    1 
ATOM   1771 C CB   . SER A 1 113 ? -11.70175 -30.54046 21.50684  1.000 22.46385 ? 113 SER A CB   1 
ATOM   1772 O OG   . SER A 1 113 ? -11.43228 -30.09988 22.81661  1.000 24.23145 ? 113 SER A OG   1 
ATOM   1773 H H    . SER A 1 113 ? -14.17541 -29.98378 21.51326  1.000 25.52759 ? 113 SER A H    1 
ATOM   1774 H HA   . SER A 1 113 ? -11.97205 -28.65605 20.73097  1.000 26.18771 ? 113 SER A HA   1 
ATOM   1775 H HB2  . SER A 1 113 ? -12.23988 -31.34607 21.55488  1.000 27.00691 ? 113 SER A HB2  1 
ATOM   1776 H HB3  . SER A 1 113 ? -10.85994 -30.72974 21.06365  1.000 27.00691 ? 113 SER A HB3  1 
ATOM   1777 H HG   . SER A 1 113 ? -10.82011 -29.52478 22.80603  1.000 29.12803 ? 113 SER A HG   1 
ATOM   1778 N N    . VAL A 1 114 ? -11.68385 -29.43509 18.39397  1.000 21.87794 ? 114 VAL A N    1 
ATOM   1779 C CA   . VAL A 1 114 ? -11.50174 -29.91593 17.02744  1.000 20.75040 ? 114 VAL A CA   1 
ATOM   1780 C C    . VAL A 1 114 ? -10.22284 -30.74452 16.96246  1.000 21.87702 ? 114 VAL A C    1 
ATOM   1781 O O    . VAL A 1 114 ? -9.15869  -30.30174 17.40727  1.000 22.52927 ? 114 VAL A O    1 
ATOM   1782 C CB   . VAL A 1 114 ? -11.44636 -28.74472 16.02138  1.000 20.73253 ? 114 VAL A CB   1 
ATOM   1783 C CG1  . VAL A 1 114 ? -11.09567 -29.24198 14.60133  1.000 20.42843 ? 114 VAL A CG1  1 
ATOM   1784 C CG2  . VAL A 1 114 ? -12.76893 -27.97980 16.01629  1.000 20.15162 ? 114 VAL A CG2  1 
ATOM   1785 H H    . VAL A 1 114 ? -11.18056 -28.76473 18.58609  1.000 26.30381 ? 114 VAL A H    1 
ATOM   1786 H HA   . VAL A 1 114 ? -12.24934 -30.48810 16.79372  1.000 24.95077 ? 114 VAL A HA   1 
ATOM   1787 H HB   . VAL A 1 114 ? -10.74390 -28.13624 16.29923  1.000 24.92933 ? 114 VAL A HB   1 
ATOM   1788 H HG11 . VAL A 1 114 ? -10.36901 -29.88173 14.66123  1.000 24.56441 ? 114 VAL A HG11 1 
ATOM   1789 H HG12 . VAL A 1 114 ? -11.87743 -29.66478 14.21275  1.000 24.56441 ? 114 VAL A HG12 1 
ATOM   1790 H HG13 . VAL A 1 114 ? -10.82552 -28.48436 14.05918  1.000 24.56441 ? 114 VAL A HG13 1 
ATOM   1791 H HG21 . VAL A 1 114 ? -12.64633 -27.14017 15.54629  1.000 24.23223 ? 114 VAL A HG21 1 
ATOM   1792 H HG22 . VAL A 1 114 ? -13.44164 -28.51515 15.56712  1.000 24.23223 ? 114 VAL A HG22 1 
ATOM   1793 H HG23 . VAL A 1 114 ? -13.03892 -27.80975 16.93231  1.000 24.23223 ? 114 VAL A HG23 1 
ATOM   1794 N N    . LEU A 1 115 ? -10.33620 -31.95378 16.41338  1.000 20.95619 ? 115 LEU A N    1 
ATOM   1795 C CA   . LEU A 1 115 ? -9.18979  -32.76447 16.01041  1.000 21.01437 ? 115 LEU A CA   1 
ATOM   1796 C C    . LEU A 1 115 ? -9.04807  -32.58640 14.49810  1.000 20.62710 ? 115 LEU A C    1 
ATOM   1797 O O    . LEU A 1 115 ? -9.74682  -33.23573 13.71713  1.000 20.31245 ? 115 LEU A O    1 
ATOM   1798 C CB   . LEU A 1 115 ? -9.38878  -34.22158 16.39463  1.000 20.60037 ? 115 LEU A CB   1 
ATOM   1799 C CG   . LEU A 1 115 ? -8.19874  -35.13517 16.11080  1.000 22.75172 ? 115 LEU A CG   1 
ATOM   1800 C CD1  . LEU A 1 115 ? -7.01524  -34.72359 16.96694  1.000 24.23420 ? 115 LEU A CD1  1 
ATOM   1801 C CD2  . LEU A 1 115 ? -8.56099  -36.58278 16.35894  1.000 23.31286 ? 115 LEU A CD2  1 
ATOM   1802 H H    . LEU A 1 115 ? -11.09078 -32.33676 16.25999  1.000 25.19771 ? 115 LEU A H    1 
ATOM   1803 H HA   . LEU A 1 115 ? -8.38299  -32.45490 16.45103  1.000 25.26754 ? 115 LEU A HA   1 
ATOM   1804 H HB2  . LEU A 1 115 ? -9.56832  -34.26500 17.34688  1.000 24.77074 ? 115 LEU A HB2  1 
ATOM   1805 H HB3  . LEU A 1 115 ? -10.14655 -34.56808 15.89802  1.000 24.77074 ? 115 LEU A HB3  1 
ATOM   1806 H HG   . LEU A 1 115 ? -7.94717  -35.05233 15.17766  1.000 27.35236 ? 115 LEU A HG   1 
ATOM   1807 H HD11 . LEU A 1 115 ? -7.33981  -34.41756 17.82827  1.000 29.13134 ? 115 LEU A HD11 1 
ATOM   1808 H HD12 . LEU A 1 115 ? -6.43075  -35.48844 17.08643  1.000 29.13134 ? 115 LEU A HD12 1 
ATOM   1809 H HD13 . LEU A 1 115 ? -6.53633  -34.00783 16.52059  1.000 29.13134 ? 115 LEU A HD13 1 
ATOM   1810 H HD21 . LEU A 1 115 ? -7.78021  -37.13563 16.19880  1.000 28.02573 ? 115 LEU A HD21 1 
ATOM   1811 H HD22 . LEU A 1 115 ? -8.85357  -36.68196 17.27843  1.000 28.02573 ? 115 LEU A HD22 1 
ATOM   1812 H HD23 . LEU A 1 115 ? -9.27607  -36.83737 15.75500  1.000 28.02573 ? 115 LEU A HD23 1 
ATOM   1813 N N    . ALA A 1 116 ? -8.17643  -31.66039 14.09794  1.000 20.08132 ? 116 ALA A N    1 
ATOM   1814 C CA   . ALA A 1 116 ? -7.92816  -31.41724 12.68474  1.000 19.78147 ? 116 ALA A CA   1 
ATOM   1815 C C    . ALA A 1 116 ? -7.16697  -32.60583 12.12808  1.000 22.57948 ? 116 ALA A C    1 
ATOM   1816 O O    . ALA A 1 116 ? -6.19553  -33.05930 12.73614  1.000 24.58700 ? 116 ALA A O    1 
ATOM   1817 C CB   . ALA A 1 116 ? -7.12744  -30.13486 12.49044  1.000 21.11378 ? 116 ALA A CB   1 
ATOM   1818 H H    . ALA A 1 116 ? -7.71770  -31.16132 14.62718  1.000 24.14788 ? 116 ALA A H    1 
ATOM   1819 H HA   . ALA A 1 116 ? -8.76489  -31.30726 12.20653  1.000 23.78805 ? 116 ALA A HA   1 
ATOM   1820 H HB1  . ALA A 1 116 ? -6.94522  -30.01650 11.54509  1.000 25.38682 ? 116 ALA A HB1  1 
ATOM   1821 H HB2  . ALA A 1 116 ? -7.64541  -29.38555 12.82381  1.000 25.38682 ? 116 ALA A HB2  1 
ATOM   1822 H HB3  . ALA A 1 116 ? -6.29399  -30.20547 12.98165  1.000 25.38682 ? 116 ALA A HB3  1 
ATOM   1823 N N    . CYS A 1 117 ? -7.62509  -33.12903 10.99219  1.000 20.92598 ? 117 CYS A N    1 
ATOM   1824 C CA   . CYS A 1 117 ? -7.02011  -34.28967 10.37667  1.000 21.47551 ? 117 CYS A CA   1 
ATOM   1825 C C    . CYS A 1 117 ? -6.81800  -34.07677 8.88632   1.000 20.98299 ? 117 CYS A C    1 
ATOM   1826 O O    . CYS A 1 117 ? -7.59951  -33.38304 8.23633   1.000 20.55317 ? 117 CYS A O    1 
ATOM   1827 C CB   . CYS A 1 117 ? -7.88738  -35.52796 10.54123  1.000 22.14586 ? 117 CYS A CB   1 
ATOM   1828 S SG   . CYS A 1 117 ? -8.11207  -36.02953 12.22694  1.000 23.20100 ? 117 CYS A SG   1 
ATOM   1829 H H    . CYS A 1 117 ? -8.29838  -32.81779 10.55698  1.000 25.16147 ? 117 CYS A H    1 
ATOM   1830 H HA   . CYS A 1 117 ? -6.15592  -34.42503 10.79590  1.000 25.82091 ? 117 CYS A HA   1 
ATOM   1831 H HB2  . CYS A 1 117 ? -8.76387  -35.34573 10.16778  1.000 26.62532 ? 117 CYS A HB2  1 
ATOM   1832 H HB3  . CYS A 1 117 ? -7.47118  -36.26452 10.06671  1.000 26.62532 ? 117 CYS A HB3  1 
ATOM   1833 H HG   . CYS A 1 117 ? -8.91123  -35.30158 12.74793  1.000 27.89149 ? 117 CYS A HG   1 
ATOM   1834 N N    . TYR A 1 118 ? -5.79392  -34.73379 8.34117   1.000 21.79358 ? 118 TYR A N    1 
ATOM   1835 C CA   . TYR A 1 118 ? -5.58491  -34.83505 6.90000   1.000 22.69252 ? 118 TYR A CA   1 
ATOM   1836 C C    . TYR A 1 118 ? -5.29083  -36.28413 6.54863   1.000 23.84535 ? 118 TYR A C    1 
ATOM   1837 O O    . TYR A 1 118 ? -4.54799  -36.96208 7.25963   1.000 23.87879 ? 118 TYR A O    1 
ATOM   1838 C CB   . TYR A 1 118 ? -4.45257  -33.91327 6.44859   1.000 24.60140 ? 118 TYR A CB   1 
ATOM   1839 C CG   . TYR A 1 118 ? -4.81688  -32.50140 6.77817   1.000 24.12338 ? 118 TYR A CG   1 
ATOM   1840 C CD1  . TYR A 1 118 ? -4.52329  -31.96131 8.02224   1.000 27.39467 ? 118 TYR A CD1  1 
ATOM   1841 C CD2  . TYR A 1 118 ? -5.54035  -31.73761 5.88111   1.000 25.17412 ? 118 TYR A CD2  1 
ATOM   1842 C CE1  . TYR A 1 118 ? -4.90698  -30.67708 8.34143   1.000 26.79308 ? 118 TYR A CE1  1 
ATOM   1843 C CE2  . TYR A 1 118 ? -5.91915  -30.46605 6.18432   1.000 25.71880 ? 118 TYR A CE2  1 
ATOM   1844 C CZ   . TYR A 1 118 ? -5.60907  -29.93859 7.41481   1.000 26.95037 ? 118 TYR A CZ   1 
ATOM   1845 O OH   . TYR A 1 118 ? -6.00783  -28.65841 7.69795   1.000 25.19048 ? 118 TYR A OH   1 
ATOM   1846 H H    . TYR A 1 118 ? -5.19072  -35.14005 8.80019   1.000 26.20259 ? 118 TYR A H    1 
ATOM   1847 H HA   . TYR A 1 118 ? -6.38327  -34.57144 6.41624   1.000 27.28131 ? 118 TYR A HA   1 
ATOM   1848 H HB2  . TYR A 1 118 ? -3.63289  -34.14512 6.91257   1.000 29.57197 ? 118 TYR A HB2  1 
ATOM   1849 H HB3  . TYR A 1 118 ? -4.32486  -33.99164 5.49023   1.000 29.57197 ? 118 TYR A HB3  1 
ATOM   1850 H HD1  . TYR A 1 118 ? -4.06218  -32.47212 8.64783   1.000 32.92389 ? 118 TYR A HD1  1 
ATOM   1851 H HD2  . TYR A 1 118 ? -5.77218  -32.09902 5.05616   1.000 30.25923 ? 118 TYR A HD2  1 
ATOM   1852 H HE1  . TYR A 1 118 ? -4.69486  -30.31400 9.17093   1.000 32.20199 ? 118 TYR A HE1  1 
ATOM   1853 H HE2  . TYR A 1 118 ? -6.38565  -29.95651 5.56170   1.000 30.91285 ? 118 TYR A HE2  1 
ATOM   1854 H HH   . TYR A 1 118 ? -5.83225  -28.47318 8.49824   1.000 30.27887 ? 118 TYR A HH   1 
ATOM   1855 N N    . ASN A 1 119 ? -5.90613  -36.76518 5.46590   1.000 24.92644 ? 119 ASN A N    1 
ATOM   1856 C CA   . ASN A 1 119 ? -5.67450  -38.12274 4.97558   1.000 28.74535 ? 119 ASN A CA   1 
ATOM   1857 C C    . ASN A 1 119 ? -5.94521  -39.16159 6.06360   1.000 25.80348 ? 119 ASN A C    1 
ATOM   1858 O O    . ASN A 1 119 ? -5.24411  -40.17112 6.17207   1.000 25.27913 ? 119 ASN A O    1 
ATOM   1859 C CB   . ASN A 1 119 ? -4.25204  -38.28075 4.44125   1.000 27.41098 ? 119 ASN A CB   1 
ATOM   1860 C CG   . ASN A 1 119 ? -3.94268  -37.30798 3.33654   1.000 31.63784 ? 119 ASN A CG   1 
ATOM   1861 O OD1  . ASN A 1 119 ? -3.08292  -36.43941 3.47812   1.000 35.43251 ? 119 ASN A OD1  1 
ATOM   1862 N ND2  . ASN A 1 119 ? -4.64386  -37.44533 2.22087   1.000 34.92152 ? 119 ASN A ND2  1 
ATOM   1863 H H    . ASN A 1 119 ? -6.46873  -36.31805 4.99352   1.000 29.96202 ? 119 ASN A H    1 
ATOM   1864 H HA   . ASN A 1 119 ? -6.29499  -38.28692 4.24829   1.000 34.54471 ? 119 ASN A HA   1 
ATOM   1865 H HB2  . ASN A 1 119 ? -3.62286  -38.12679 5.16329   1.000 32.94347 ? 119 ASN A HB2  1 
ATOM   1866 H HB3  . ASN A 1 119 ? -4.14234  -39.17880 4.09146   1.000 32.94347 ? 119 ASN A HB3  1 
ATOM   1867 H HD21 . ASN A 1 119 ? -4.50607  -36.91465 1.55831   1.000 41.95612 ? 119 ASN A HD21 1 
ATOM   1868 H HD22 . ASN A 1 119 ? -5.23682  -38.06517 2.15923   1.000 41.95612 ? 119 ASN A HD22 1 
ATOM   1869 N N    . GLY A 1 120 ? -6.96317  -38.90695 6.87274   1.000 23.52808 ? 120 GLY A N    1 
ATOM   1870 C CA   . GLY A 1 120 ? -7.28279  -39.80854 7.95655   1.000 23.29201 ? 120 GLY A CA   1 
ATOM   1871 C C    . GLY A 1 120 ? -6.31993  -39.79307 9.11961   1.000 23.90690 ? 120 GLY A C    1 
ATOM   1872 O O    . GLY A 1 120 ? -6.46743  -40.61593 10.02750  1.000 25.84731 ? 120 GLY A O    1 
ATOM   1873 H H    . GLY A 1 120 ? -7.47897  -38.22146 6.81231   1.000 28.28399 ? 120 GLY A H    1 
ATOM   1874 H HA2  . GLY A 1 120 ? -8.16060  -39.57899 8.29957   1.000 28.00071 ? 120 GLY A HA2  1 
ATOM   1875 H HA3  . GLY A 1 120 ? -7.30672  -40.71334 7.60776   1.000 28.00071 ? 120 GLY A HA3  1 
ATOM   1876 N N    . SER A 1 121 ? -5.35433  -38.88117 9.14267   1.000 24.23623 ? 121 SER A N    1 
ATOM   1877 C CA   . SER A 1 121 ? -4.35872  -38.86547 10.20049  1.000 25.12814 ? 121 SER A CA   1 
ATOM   1878 C C    . SER A 1 121 ? -4.45164  -37.56695 10.98823  1.000 26.23539 ? 121 SER A C    1 
ATOM   1879 O O    . SER A 1 121 ? -4.44243  -36.48039 10.39373  1.000 25.23237 ? 121 SER A O    1 
ATOM   1880 C CB   . SER A 1 121 ? -2.94046  -39.03978 9.61982   1.000 30.70715 ? 121 SER A CB   1 
ATOM   1881 O OG   . SER A 1 121 ? -2.71614  -40.36230 9.16149   1.000 37.60989 ? 121 SER A OG   1 
ATOM   1882 H H    . SER A 1 121 ? -5.25734  -38.26145 8.55432   1.000 29.13376 ? 121 SER A H    1 
ATOM   1883 H HA   . SER A 1 121 ? -4.52737  -39.59910 10.81224  1.000 30.20406 ? 121 SER A HA   1 
ATOM   1884 H HB2  . SER A 1 121 ? -2.83179  -38.42895 8.87419   1.000 36.89887 ? 121 SER A HB2  1 
ATOM   1885 H HB3  . SER A 1 121 ? -2.29288  -38.83607 10.31267  1.000 36.89887 ? 121 SER A HB3  1 
ATOM   1886 H HG   . SER A 1 121 ? -2.53519  -40.86436 9.81017   1.000 45.18216 ? 121 SER A HG   1 
ATOM   1887 N N    . PRO A 1 122 ? -4.55215  -37.63401 12.31910  1.000 28.38476 ? 122 PRO A N    1 
ATOM   1888 C CA   . PRO A 1 122 ? -4.67483  -36.40523 13.11063  1.000 29.35508 ? 122 PRO A CA   1 
ATOM   1889 C C    . PRO A 1 122 ? -3.44694  -35.51079 13.02474  1.000 29.12620 ? 122 PRO A C    1 
ATOM   1890 O O    . PRO A 1 122 ? -2.30962  -35.97046 13.13725  1.000 34.47114 ? 122 PRO A O    1 
ATOM   1891 C CB   . PRO A 1 122 ? -4.87390  -36.93213 14.53884  1.000 32.47377 ? 122 PRO A CB   1 
ATOM   1892 C CG   . PRO A 1 122 ? -5.55380  -38.25344 14.34258  1.000 34.61370 ? 122 PRO A CG   1 
ATOM   1893 C CD   . PRO A 1 122 ? -4.86358  -38.83053 13.12414  1.000 34.26464 ? 122 PRO A CD   1 
ATOM   1894 H HA   . PRO A 1 122 ? -5.44911  -35.90263 12.81268  1.000 35.27639 ? 122 PRO A HA   1 
ATOM   1895 H HB2  . PRO A 1 122 ? -4.01597  -37.04038 14.97832  1.000 39.01881 ? 122 PRO A HB2  1 
ATOM   1896 H HB3  . PRO A 1 122 ? -5.43181  -36.32190 15.04604  1.000 39.01881 ? 122 PRO A HB3  1 
ATOM   1897 H HG2  . PRO A 1 122 ? -5.42375  -38.81758 15.12087  1.000 41.58673 ? 122 PRO A HG2  1 
ATOM   1898 H HG3  . PRO A 1 122 ? -6.50149  -38.12351 14.18162  1.000 41.58673 ? 122 PRO A HG3  1 
ATOM   1899 H HD2  . PRO A 1 122 ? -4.05242  -39.29930 13.37547  1.000 41.16785 ? 122 PRO A HD2  1 
ATOM   1900 H HD3  . PRO A 1 122 ? -5.45595  -39.42793 12.64133  1.000 41.16785 ? 122 PRO A HD3  1 
ATOM   1901 N N    . SER A 1 123 ? -3.70450  -34.21086 12.86578  1.000 27.09366 ? 123 SER A N    1 
ATOM   1902 C CA   . SER A 1 123 ? -2.68312  -33.17498 12.77501  1.000 26.75749 ? 123 SER A CA   1 
ATOM   1903 C C    . SER A 1 123 ? -2.55893  -32.33945 14.04460  1.000 26.23503 ? 123 SER A C    1 
ATOM   1904 O O    . SER A 1 123 ? -1.44843  -31.94553 14.41053  1.000 28.49736 ? 123 SER A O    1 
ATOM   1905 C CB   . SER A 1 123 ? -2.99341  -32.25944 11.58260  1.000 31.16714 ? 123 SER A CB   1 
ATOM   1906 O OG   . SER A 1 123 ? -2.18562  -31.09623 11.57667  1.000 40.86681 ? 123 SER A OG   1 
ATOM   1907 H H    . SER A 1 123 ? -4.50132  -33.89300 12.80542  1.000 32.56269 ? 123 SER A H    1 
ATOM   1908 H HA   . SER A 1 123 ? -1.82013  -33.59122 12.62374  1.000 32.15928 ? 123 SER A HA   1 
ATOM   1909 H HB2  . SER A 1 123 ? -2.83331  -32.75260 10.76281  1.000 37.45086 ? 123 SER A HB2  1 
ATOM   1910 H HB3  . SER A 1 123 ? -3.92413  -31.99065 11.63169  1.000 37.45086 ? 123 SER A HB3  1 
ATOM   1911 H HG   . SER A 1 123 ? -2.07150  -30.82972 10.78829  1.000 49.09046 ? 123 SER A HG   1 
ATOM   1912 N N    . GLY A 1 124 ? -3.65216  -32.04926 14.73650  1.000 24.09281 ? 124 GLY A N    1 
ATOM   1913 C CA   . GLY A 1 124 ? -3.55553  -31.24580 15.94951  1.000 25.02444 ? 124 GLY A CA   1 
ATOM   1914 C C    . GLY A 1 124 ? -4.93205  -30.99664 16.51824  1.000 24.61999 ? 124 GLY A C    1 
ATOM   1915 O O    . GLY A 1 124 ? -5.95090  -31.33746 15.91249  1.000 24.22745 ? 124 GLY A O    1 
ATOM   1916 H H    . GLY A 1 124 ? -4.44839  -32.30021 14.52998  1.000 28.96166 ? 124 GLY A H    1 
ATOM   1917 H HA2  . GLY A 1 124 ? -3.02070  -31.71048 16.61203  1.000 30.07962 ? 124 GLY A HA2  1 
ATOM   1918 H HA3  . GLY A 1 124 ? -3.13889  -30.39312 15.74886  1.000 30.07962 ? 124 GLY A HA3  1 
ATOM   1919 N N    . VAL A 1 125 ? -4.95336  -30.36526 17.69390  1.000 24.09244 ? 125 VAL A N    1 
ATOM   1920 C CA   A VAL A 1 125 ? -6.18765  -30.21889 18.45185  0.500 24.51538 ? 125 VAL A CA   1 
ATOM   1921 C CA   B VAL A 1 125 ? -6.17985  -30.21881 18.46897  0.500 24.51785 ? 125 VAL A CA   1 
ATOM   1922 C C    . VAL A 1 125 ? -6.28479  -28.80718 19.02432  1.000 24.38855 ? 125 VAL A C    1 
ATOM   1923 O O    . VAL A 1 125 ? -5.29945  -28.24807 19.51690  1.000 23.64853 ? 125 VAL A O    1 
ATOM   1924 C CB   A VAL A 1 125 ? -6.27447  -31.29691 19.56254  0.500 25.72318 ? 125 VAL A CB   1 
ATOM   1925 C CB   B VAL A 1 125 ? -6.21118  -31.24237 19.62355  0.500 26.53510 ? 125 VAL A CB   1 
ATOM   1926 C CG1  A VAL A 1 125 ? -5.24827  -31.04446 20.64141  0.500 27.85332 ? 125 VAL A CG1  1 
ATOM   1927 C CG1  B VAL A 1 125 ? -7.43427  -31.06882 20.46030  0.500 26.34238 ? 125 VAL A CG1  1 
ATOM   1928 C CG2  A VAL A 1 125 ? -7.68113  -31.36265 20.12205  0.500 26.94517 ? 125 VAL A CG2  1 
ATOM   1929 C CG2  B VAL A 1 125 ? -6.18571  -32.61523 19.07597  0.500 26.67405 ? 125 VAL A CG2  1 
ATOM   1930 H H    . VAL A 1 125 ? -4.26196  -30.01567 18.06721  1.000 28.96121 ? 125 VAL A H    1 
ATOM   1931 H HA   . VAL A 1 125 ? -6.94532  -30.32164 17.85497  1.000 29.47171 ? 125 VAL A HA   1 
ATOM   1932 H HB   A VAL A 1 125 ? -6.07167  -32.16524 19.18074  0.500 30.91811 ? 125 VAL A HB   1 
ATOM   1933 H HB   B VAL A 1 125 ? -5.43260  -31.09840 20.18389  0.500 31.89242 ? 125 VAL A HB   1 
ATOM   1934 H HG11 A VAL A 1 125 ? -4.38919  -30.87099 20.22573  0.500 33.47428 ? 125 VAL A HG11 1 
ATOM   1935 H HG11 B VAL A 1 125 ? -7.47562  -30.15144 20.77270  0.500 31.66115 ? 125 VAL A HG11 1 
ATOM   1936 H HG12 A VAL A 1 125 ? -5.52342  -30.27591 21.16536  0.500 33.47428 ? 125 VAL A HG12 1 
ATOM   1937 H HG12 B VAL A 1 125 ? -8.21598  -31.27073 19.92266  0.500 31.66115 ? 125 VAL A HG12 1 
ATOM   1938 H HG13 A VAL A 1 125 ? -5.18844  -31.82811 21.20993  0.500 33.47428 ? 125 VAL A HG13 1 
ATOM   1939 H HG13 B VAL A 1 125 ? -7.38782  -31.67411 21.21685  0.500 31.66115 ? 125 VAL A HG13 1 
ATOM   1940 H HG21 A VAL A 1 125 ? -8.30940  -31.44714 19.38785  0.500 32.38450 ? 125 VAL A HG21 1 
ATOM   1941 H HG21 B VAL A 1 125 ? -5.44195  -32.69518 18.45846  0.500 32.05915 ? 125 VAL A HG21 1 
ATOM   1942 H HG22 A VAL A 1 125 ? -7.75214  -32.13211 20.70838  0.500 32.38450 ? 125 VAL A HG22 1 
ATOM   1943 H HG22 B VAL A 1 125 ? -6.07843  -33.24457 19.80626  0.500 32.05915 ? 125 VAL A HG22 1 
ATOM   1944 H HG23 A VAL A 1 125 ? -7.86135  -30.54979 20.61973  0.500 32.38450 ? 125 VAL A HG23 1 
ATOM   1945 H HG23 B VAL A 1 125 ? -7.02044  -32.78580 18.61225  0.500 32.05915 ? 125 VAL A HG23 1 
ATOM   1946 N N    . TYR A 1 126 ? -7.48950  -28.23945 18.95561  1.000 22.51988 ? 126 TYR A N    1 
ATOM   1947 C CA   . TYR A 1 126 ? -7.72852  -26.88823 19.44365  1.000 22.07956 ? 126 TYR A CA   1 
ATOM   1948 C C    . TYR A 1 126 ? -9.20891  -26.71601 19.74571  1.000 22.19816 ? 126 TYR A C    1 
ATOM   1949 O O    . TYR A 1 126 ? -10.06090 -27.41361 19.18911  1.000 22.07943 ? 126 TYR A O    1 
ATOM   1950 C CB   . TYR A 1 126 ? -7.27439  -25.81190 18.44018  1.000 21.82484 ? 126 TYR A CB   1 
ATOM   1951 C CG   . TYR A 1 126 ? -7.79638  -25.96582 17.02048  1.000 21.73017 ? 126 TYR A CG   1 
ATOM   1952 C CD1  . TYR A 1 126 ? -9.00097  -25.40412 16.62578  1.000 22.72929 ? 126 TYR A CD1  1 
ATOM   1953 C CD2  . TYR A 1 126 ? -7.06641  -26.65891 16.07106  1.000 22.88052 ? 126 TYR A CD2  1 
ATOM   1954 C CE1  . TYR A 1 126 ? -9.46506  -25.55006 15.32305  1.000 21.63654 ? 126 TYR A CE1  1 
ATOM   1955 C CE2  . TYR A 1 126 ? -7.51999  -26.80311 14.77531  1.000 25.38519 ? 126 TYR A CE2  1 
ATOM   1956 C CZ   . TYR A 1 126 ? -8.71564  -26.24692 14.40422  1.000 22.75888 ? 126 TYR A CZ   1 
ATOM   1957 O OH   . TYR A 1 126 ? -9.15870  -26.38974 13.10807  1.000 23.16409 ? 126 TYR A OH   1 
ATOM   1958 H H    . TYR A 1 126 ? -8.18708  -28.62114 18.62806  1.000 27.07415 ? 126 TYR A H    1 
ATOM   1959 H HA   . TYR A 1 126 ? -7.22595  -26.77419 20.26543  1.000 26.54576 ? 126 TYR A HA   1 
ATOM   1960 H HB2  . TYR A 1 126 ? -7.57485  -24.94847 18.76439  1.000 26.24010 ? 126 TYR A HB2  1 
ATOM   1961 H HB3  . TYR A 1 126 ? -6.30569  -25.82992 18.39330  1.000 26.24010 ? 126 TYR A HB3  1 
ATOM   1962 H HD1  . TYR A 1 126 ? -9.50578  -24.92292 17.24101  1.000 27.32544 ? 126 TYR A HD1  1 
ATOM   1963 H HD2  . TYR A 1 126 ? -6.25119  -27.03640 16.31152  1.000 27.50692 ? 126 TYR A HD2  1 
ATOM   1964 H HE1  . TYR A 1 126 ? -10.27990 -25.17748 15.07383  1.000 26.01414 ? 126 TYR A HE1  1 
ATOM   1965 H HE2  . TYR A 1 126 ? -7.01455  -27.27721 14.15510  1.000 30.51251 ? 126 TYR A HE2  1 
ATOM   1966 H HH   . TYR A 1 126 ? -9.92792  -26.06149 13.02958  1.000 27.84720 ? 126 TYR A HH   1 
ATOM   1967 N N    . GLN A 1 127 ? -9.49731  -25.74397 20.60555  1.000 22.66383 ? 127 GLN A N    1 
ATOM   1968 C CA   . GLN A 1 127 ? -10.85118 -25.47647 21.07322  1.000 21.70147 ? 127 GLN A CA   1 
ATOM   1969 C C    . GLN A 1 127 ? -11.53573 -24.45080 20.17281  1.000 22.89962 ? 127 GLN A C    1 
ATOM   1970 O O    . GLN A 1 127 ? -10.90452 -23.50286 19.70276  1.000 23.43391 ? 127 GLN A O    1 
ATOM   1971 C CB   . GLN A 1 127 ? -10.78989 -24.96489 22.51274  1.000 25.89444 ? 127 GLN A CB   1 
ATOM   1972 C CG   . GLN A 1 127 ? -12.07612 -25.05584 23.25820  1.000 30.02417 ? 127 GLN A CG   1 
ATOM   1973 C CD   . GLN A 1 127 ? -12.26929 -26.41125 23.87010  1.000 28.54381 ? 127 GLN A CD   1 
ATOM   1974 O OE1  . GLN A 1 127 ? -11.78286 -27.41911 23.35389  1.000 27.19283 ? 127 GLN A OE1  1 
ATOM   1975 N NE2  . GLN A 1 127 ? -12.96842 -26.44854 24.98820  1.000 36.62081 ? 127 GLN A NE2  1 
ATOM   1976 H H    . GLN A 1 127 ? -8.91028  -25.21236 20.94079  1.000 27.24689 ? 127 GLN A H    1 
ATOM   1977 H HA   . GLN A 1 127 ? -11.38445 -26.28628 21.04610  1.000 26.09206 ? 127 GLN A HA   1 
ATOM   1978 H HB2  . GLN A 1 127 ? -10.13274 -25.48769 22.99827  1.000 31.12362 ? 127 GLN A HB2  1 
ATOM   1979 H HB3  . GLN A 1 127 ? -10.52591 -24.03163 22.49754  1.000 31.12362 ? 127 GLN A HB3  1 
ATOM   1980 H HG2  . GLN A 1 127 ? -12.08046 -24.39721 23.97030  1.000 36.07929 ? 127 GLN A HG2  1 
ATOM   1981 H HG3  . GLN A 1 127 ? -12.81185 -24.88981 22.64825  1.000 36.07929 ? 127 GLN A HG3  1 
ATOM   1982 H HE21 . GLN A 1 127 ? -13.28269 -25.72152 25.32328  1.000 43.99526 ? 127 GLN A HE21 1 
ATOM   1983 H HE22 . GLN A 1 127 ? -13.10991 -27.19986 25.38201  1.000 43.99526 ? 127 GLN A HE22 1 
ATOM   1984 N N    . CYS A 1 128 ? -12.83638 -24.65543 19.93452  1.000 21.89271 ? 128 CYS A N    1 
ATOM   1985 C CA   . CYS A 1 128 ? -13.66809 -23.70124 19.21368  1.000 21.50586 ? 128 CYS A CA   1 
ATOM   1986 C C    . CYS A 1 128 ? -14.97123 -23.47747 19.96087  1.000 22.91833 ? 128 CYS A C    1 
ATOM   1987 O O    . CYS A 1 128 ? -15.46343 -24.36714 20.66325  1.000 23.12830 ? 128 CYS A O    1 
ATOM   1988 C CB   . CYS A 1 128 ? -14.01881 -24.16450 17.78647  1.000 19.55778 ? 128 CYS A CB   1 
ATOM   1989 S SG   . CYS A 1 128 ? -12.62379 -24.20345 16.64449  1.000 23.00635 ? 128 CYS A SG   1 
ATOM   1990 H H    . CYS A 1 128 ? -13.26387 -25.35708 20.18856  1.000 26.32155 ? 128 CYS A H    1 
ATOM   1991 H HA   . CYS A 1 128 ? -13.17336 -22.86879 19.15731  1.000 25.85732 ? 128 CYS A HA   1 
ATOM   1992 H HB2  . CYS A 1 128 ? -14.38260 -25.06242 17.83449  1.000 23.51962 ? 128 CYS A HB2  1 
ATOM   1993 H HB3  . CYS A 1 128 ? -14.68050 -23.55767 17.41927  1.000 23.51962 ? 128 CYS A HB3  1 
ATOM   1994 H HG   . CYS A 1 128 ? -11.84963 -25.04772 17.00207  1.000 27.65792 ? 128 CYS A HG   1 
ATOM   1995 N N    . ALA A 1 129 ? -15.53464 -22.28705 19.79309  1.000 22.87869 ? 129 ALA A N    1 
ATOM   1996 C CA   . ALA A 1 129 ? -16.91429 -22.02326 20.16978  1.000 23.88017 ? 129 ALA A CA   1 
ATOM   1997 C C    . ALA A 1 129 ? -17.79261 -22.06578 18.92704  1.000 22.80475 ? 129 ALA A C    1 
ATOM   1998 O O    . ALA A 1 129 ? -17.41237 -21.56576 17.86719  1.000 21.68883 ? 129 ALA A O    1 
ATOM   1999 C CB   . ALA A 1 129 ? -17.06307 -20.65614 20.83925  1.000 23.27471 ? 129 ALA A CB   1 
ATOM   2000 H H    . ALA A 1 129 ? -15.13012 -21.60638 19.45746  1.000 27.50472 ? 129 ALA A H    1 
ATOM   2001 H HA   . ALA A 1 129 ? -17.20663 -22.70078 20.79939  1.000 28.70649 ? 129 ALA A HA   1 
ATOM   2002 H HB1  . ALA A 1 129 ? -16.38895 -20.56830 21.53117  1.000 27.97994 ? 129 ALA A HB1  1 
ATOM   2003 H HB2  . ALA A 1 129 ? -16.94390 -19.96282 20.17141  1.000 27.97994 ? 129 ALA A HB2  1 
ATOM   2004 H HB3  . ALA A 1 129 ? -17.94851 -20.59047 21.22986  1.000 27.97994 ? 129 ALA A HB3  1 
ATOM   2005 N N    . MET A 1 130 ? -18.97102 -22.65567 19.07040  1.000 22.40743 ? 130 MET A N    1 
ATOM   2006 C CA   . MET A 1 130 ? -20.02473 -22.46169 18.08541  1.000 22.19058 ? 130 MET A CA   1 
ATOM   2007 C C    . MET A 1 130 ? -20.53960 -21.04569 18.26474  1.000 23.63876 ? 130 MET A C    1 
ATOM   2008 O O    . MET A 1 130 ? -21.17106 -20.73530 19.27984  1.000 24.97316 ? 130 MET A O    1 
ATOM   2009 C CB   . MET A 1 130 ? -21.14158 -23.47969 18.27321  1.000 22.40861 ? 130 MET A CB   1 
ATOM   2010 C CG   . MET A 1 130 ? -22.26577 -23.35797 17.26060  1.000 26.58142 ? 130 MET A CG   1 
ATOM   2011 S SD   . MET A 1 130 ? -21.69774 -23.48940 15.55879  1.000 23.15398 ? 130 MET A SD   1 
ATOM   2012 C CE   . MET A 1 130 ? -21.03109 -25.14885 15.53583  1.000 22.10117 ? 130 MET A CE   1 
ATOM   2013 H H    . MET A 1 130 ? -19.18424 -23.17025 19.72564  1.000 26.93920 ? 130 MET A H    1 
ATOM   2014 H HA   . MET A 1 130 ? -19.67630 -22.59695 17.19030  1.000 26.67899 ? 130 MET A HA   1 
ATOM   2015 H HB2  . MET A 1 130 ? -20.76675 -24.37066 18.19211  1.000 26.94062 ? 130 MET A HB2  1 
ATOM   2016 H HB3  . MET A 1 130 ? -21.52554 -23.36038 19.15595  1.000 26.94062 ? 130 MET A HB3  1 
ATOM   2017 H HG2  . MET A 1 130 ? -22.90848 -24.06752 17.41669  1.000 31.94799 ? 130 MET A HG2  1 
ATOM   2018 H HG3  . MET A 1 130 ? -22.69330 -22.49379 17.36697  1.000 31.94799 ? 130 MET A HG3  1 
ATOM   2019 H HE1  . MET A 1 130 ? -20.75368 -25.36526 14.63189  1.000 26.57170 ? 130 MET A HE1  1 
ATOM   2020 H HE2  . MET A 1 130 ? -20.26928 -25.19146 16.13477  1.000 26.57170 ? 130 MET A HE2  1 
ATOM   2021 H HE3  . MET A 1 130 ? -21.71717 -25.76888 15.82867  1.000 26.57170 ? 130 MET A HE3  1 
ATOM   2022 N N    . ARG A 1 131 ? -20.24204 -20.17841 17.32804  1.000 21.97704 ? 131 ARG A N    1 
ATOM   2023 C CA   . ARG A 1 131 ? -20.54470 -18.77996 17.55291  1.000 22.75666 ? 131 ARG A CA   1 
ATOM   2024 C C    . ARG A 1 131 ? -22.02640 -18.53839 17.35549  1.000 24.98051 ? 131 ARG A C    1 
ATOM   2025 O O    . ARG A 1 131 ? -22.73291 -19.37197 16.78385  1.000 24.50148 ? 131 ARG A O    1 
ATOM   2026 C CB   . ARG A 1 131 ? -19.69760 -17.92168 16.63673  1.000 25.20401 ? 131 ARG A CB   1 
ATOM   2027 C CG   . ARG A 1 131 ? -18.23197 -18.17892 16.92962  1.000 23.56327 ? 131 ARG A CG   1 
ATOM   2028 C CD   . ARG A 1 131 ? -17.34004 -17.05924 16.47947  1.000 24.39438 ? 131 ARG A CD   1 
ATOM   2029 N NE   . ARG A 1 131 ? -17.78018 -15.78215 17.02661  1.000 26.07318 ? 131 ARG A NE   1 
ATOM   2030 C CZ   . ARG A 1 131 ? -17.57548 -15.37978 18.27453  1.000 27.75227 ? 131 ARG A CZ   1 
ATOM   2031 N NH1  . ARG A 1 131 ? -16.88753 -16.11160 19.13712  1.000 26.13603 ? 131 ARG A NH1  1 
ATOM   2032 N NH2  . ARG A 1 131 ? -18.08793 -14.21900 18.66953  1.000 27.65598 ? 131 ARG A NH2  1 
ATOM   2033 H H    . ARG A 1 131 ? -19.87479 -20.36478 16.57306  1.000 26.42274 ? 131 ARG A H    1 
ATOM   2034 H HA   . ARG A 1 131 ? -20.32888 -18.51543 18.46085  1.000 27.35829 ? 131 ARG A HA   1 
ATOM   2035 H HB2  . ARG A 1 131 ? -19.87910 -18.14888 15.71134  1.000 30.29510 ? 131 ARG A HB2  1 
ATOM   2036 H HB3  . ARG A 1 131 ? -19.89060 -16.98386 16.79209  1.000 30.29510 ? 131 ARG A HB3  1 
ATOM   2037 H HG2  . ARG A 1 131 ? -18.11548 -18.28736 17.88648  1.000 28.32621 ? 131 ARG A HG2  1 
ATOM   2038 H HG3  . ARG A 1 131 ? -17.95460 -18.98575 16.46810  1.000 28.32621 ? 131 ARG A HG3  1 
ATOM   2039 H HD2  . ARG A 1 131 ? -16.43423 -17.22680 16.78333  1.000 29.32354 ? 131 ARG A HD2  1 
ATOM   2040 H HD3  . ARG A 1 131 ? -17.35978 -17.00087 15.51143  1.000 29.32354 ? 131 ARG A HD3  1 
ATOM   2041 H HE   . ARG A 1 131 ? -18.20435 -15.24938 16.50140  1.000 31.33811 ? 131 ARG A HE   1 
ATOM   2042 H HH11 . ARG A 1 131 ? -16.56024 -16.86873 18.89374  1.000 31.41352 ? 131 ARG A HH11 1 
ATOM   2043 H HH12 . ARG A 1 131 ? -16.76794 -15.82983 19.94080  1.000 31.41352 ? 131 ARG A HH12 1 
ATOM   2044 H HH21 . ARG A 1 131 ? -18.54432 -13.74095 18.11928  1.000 33.23747 ? 131 ARG A HH21 1 
ATOM   2045 H HH22 . ARG A 1 131 ? -17.96317 -13.94586 19.47540  1.000 33.23747 ? 131 ARG A HH22 1 
ATOM   2046 N N    . PRO A 1 132 ? -22.53593 -17.43065 17.88183  1.000 24.07100 ? 132 PRO A N    1 
ATOM   2047 C CA   . PRO A 1 132 ? -23.96637 -17.14430 17.72372  1.000 27.54356 ? 132 PRO A CA   1 
ATOM   2048 C C    . PRO A 1 132 ? -24.43472 -17.15273 16.28540  1.000 28.12323 ? 132 PRO A C    1 
ATOM   2049 O O    . PRO A 1 132 ? -25.59740 -17.49305 16.03564  1.000 28.72836 ? 132 PRO A O    1 
ATOM   2050 C CB   . PRO A 1 132 ? -24.10240 -15.75775 18.36824  1.000 27.85347 ? 132 PRO A CB   1 
ATOM   2051 C CG   . PRO A 1 132 ? -23.08379 -15.78612 19.45232  1.000 25.47805 ? 132 PRO A CG   1 
ATOM   2052 C CD   . PRO A 1 132 ? -21.89659 -16.49637 18.82926  1.000 24.00972 ? 132 PRO A CD   1 
ATOM   2053 H HA   . PRO A 1 132 ? -24.49407 -17.78535 18.22521  1.000 33.10256 ? 132 PRO A HA   1 
ATOM   2054 H HB2  . PRO A 1 132 ? -23.90888 -15.06341 17.71912  1.000 33.47446 ? 132 PRO A HB2  1 
ATOM   2055 H HB3  . PRO A 1 132 ? -24.99614 -15.63796 18.72568  1.000 33.47446 ? 132 PRO A HB3  1 
ATOM   2056 H HG2  . PRO A 1 132 ? -22.85136 -14.88198 19.71576  1.000 30.62395 ? 132 PRO A HG2  1 
ATOM   2057 H HG3  . PRO A 1 132 ? -23.42334 -16.27746 20.21666  1.000 30.62395 ? 132 PRO A HG3  1 
ATOM   2058 H HD2  . PRO A 1 132 ? -21.32177 -15.86891 18.36367  1.000 28.86195 ? 132 PRO A HD2  1 
ATOM   2059 H HD3  . PRO A 1 132 ? -21.38783 -16.97695 19.50090  1.000 28.86195 ? 132 PRO A HD3  1 
ATOM   2060 N N    . ASN A 1 133 ? -23.57130 -16.80234 15.32752  1.000 25.07441 ? 133 ASN A N    1 
ATOM   2061 C CA   . ASN A 1 133 ? -23.93330 -16.86607 13.91811  1.000 24.92383 ? 133 ASN A CA   1 
ATOM   2062 C C    . ASN A 1 133 ? -23.58955 -18.21107 13.29149  1.000 24.17690 ? 133 ASN A C    1 
ATOM   2063 O O    . ASN A 1 133 ? -23.52512 -18.31191 12.05890  1.000 25.50021 ? 133 ASN A O    1 
ATOM   2064 C CB   . ASN A 1 133 ? -23.26733 -15.72886 13.12710  1.000 25.27640 ? 133 ASN A CB   1 
ATOM   2065 C CG   . ASN A 1 133 ? -21.76622 -15.88641 13.00734  1.000 26.06569 ? 133 ASN A CG   1 
ATOM   2066 O OD1  . ASN A 1 133 ? -21.19109 -16.85776 13.49078  1.000 23.99248 ? 133 ASN A OD1  1 
ATOM   2067 N ND2  . ASN A 1 133 ? -21.12147 -14.91990 12.35341  1.000 26.80535 ? 133 ASN A ND2  1 
ATOM   2068 H H    . ASN A 1 133 ? -22.77063 -16.52496 15.47449  1.000 30.13958 ? 133 ASN A H    1 
ATOM   2069 H HA   . ASN A 1 133 ? -24.89239 -16.73746 13.85099  1.000 29.95889 ? 133 ASN A HA   1 
ATOM   2070 H HB2  . ASN A 1 133 ? -23.63769 -15.71027 12.23078  1.000 30.38197 ? 133 ASN A HB2  1 
ATOM   2071 H HB3  . ASN A 1 133 ? -23.44398 -14.88762 13.57657  1.000 30.38197 ? 133 ASN A HB3  1 
ATOM   2072 H HD21 . ASN A 1 133 ? -20.26787 -14.96127 12.25721  1.000 32.21671 ? 133 ASN A HD21 1 
ATOM   2073 H HD22 . ASN A 1 133 ? -21.55917 -14.25508 12.02778  1.000 32.21671 ? 133 ASN A HD22 1 
ATOM   2074 N N    . PHE A 1 134 ? -23.33907 -19.23149 14.12278  1.000 24.16291 ? 134 PHE A N    1 
ATOM   2075 C CA   . PHE A 1 134 ? -23.20551 -20.63815 13.72655  1.000 23.71526 ? 134 PHE A CA   1 
ATOM   2076 C C    . PHE A 1 134 ? -22.00993 -20.88914 12.81115  1.000 23.64571 ? 134 PHE A C    1 
ATOM   2077 O O    . PHE A 1 134 ? -22.03933 -21.77636 11.95300  1.000 23.06648 ? 134 PHE A O    1 
ATOM   2078 C CB   . PHE A 1 134 ? -24.50121 -21.15722 13.09905  1.000 24.72256 ? 134 PHE A CB   1 
ATOM   2079 C CG   . PHE A 1 134 ? -25.60091 -21.38178 14.10646  1.000 24.92229 ? 134 PHE A CG   1 
ATOM   2080 C CD1  . PHE A 1 134 ? -25.49844 -22.40163 15.04717  1.000 25.73134 ? 134 PHE A CD1  1 
ATOM   2081 C CD2  . PHE A 1 134 ? -26.71389 -20.55882 14.13879  1.000 28.07062 ? 134 PHE A CD2  1 
ATOM   2082 C CE1  . PHE A 1 134 ? -26.49565 -22.60944 15.98701  1.000 28.28297 ? 134 PHE A CE1  1 
ATOM   2083 C CE2  . PHE A 1 134 ? -27.71257 -20.75936 15.07695  1.000 26.07531 ? 134 PHE A CE2  1 
ATOM   2084 C CZ   . PHE A 1 134 ? -27.60170 -21.78636 16.00388  1.000 29.64888 ? 134 PHE A CZ   1 
ATOM   2085 H H    . PHE A 1 134 ? -23.23666 -19.12723 14.97027  1.000 29.04578 ? 134 PHE A H    1 
ATOM   2086 H HA   . PHE A 1 134 ? -23.03419 -21.15427 14.52977  1.000 28.50860 ? 134 PHE A HA   1 
ATOM   2087 H HB2  . PHE A 1 134 ? -24.81805 -20.50875 12.45097  1.000 29.71736 ? 134 PHE A HB2  1 
ATOM   2088 H HB3  . PHE A 1 134 ? -24.32078 -22.00347 12.66063  1.000 29.71736 ? 134 PHE A HB3  1 
ATOM   2089 H HD1  . PHE A 1 134 ? -24.74915 -22.95250 15.04534  1.000 30.92790 ? 134 PHE A HD1  1 
ATOM   2090 H HD2  . PHE A 1 134 ? -26.79152 -19.86478 13.52464  1.000 33.73503 ? 134 PHE A HD2  1 
ATOM   2091 H HE1  . PHE A 1 134 ? -26.41907 -23.30126 16.60379  1.000 33.98985 ? 134 PHE A HE1  1 
ATOM   2092 H HE2  . PHE A 1 134 ? -28.45905 -20.20475 15.08589  1.000 31.34067 ? 134 PHE A HE2  1 
ATOM   2093 H HZ   . PHE A 1 134 ? -28.27185 -21.91906 16.63489  1.000 35.62895 ? 134 PHE A HZ   1 
ATOM   2094 N N    . THR A 1 135 ? -20.94847 -20.11603 13.01793  1.000 24.88495 ? 135 THR A N    1 
ATOM   2095 C CA   . THR A 1 135 ? -19.65064 -20.35714 12.41994  1.000 22.29657 ? 135 THR A CA   1 
ATOM   2096 C C    . THR A 1 135 ? -18.64847 -20.62372 13.53162  1.000 21.26789 ? 135 THR A C    1 
ATOM   2097 O O    . THR A 1 135 ? -18.90343 -20.35676 14.71073  1.000 20.08817 ? 135 THR A O    1 
ATOM   2098 C CB   . THR A 1 135 ? -19.15235 -19.17222 11.58182  1.000 22.61949 ? 135 THR A CB   1 
ATOM   2099 O OG1  . THR A 1 135 ? -18.93885 -18.03318 12.42343  1.000 23.83830 ? 135 THR A OG1  1 
ATOM   2100 C CG2  . THR A 1 135 ? -20.14691 -18.84893 10.48681  1.000 24.75158 ? 135 THR A CG2  1 
ATOM   2101 H H    . THR A 1 135 ? -20.96138 -19.41926 13.52186  1.000 29.91223 ? 135 THR A H    1 
ATOM   2102 H HA   . THR A 1 135 ? -19.72368 -21.12419 11.83070  1.000 26.80617 ? 135 THR A HA   1 
ATOM   2103 H HB   . THR A 1 135 ? -18.30937 -19.39897 11.15889  1.000 27.19368 ? 135 THR A HB   1 
ATOM   2104 H HG1  . THR A 1 135 ? -18.81365 -17.34823 11.95356  1.000 28.65626 ? 135 THR A HG1  1 
ATOM   2105 H HG21 . THR A 1 135 ? -19.92367 -17.99892 10.07626  1.000 29.75219 ? 135 THR A HG21 1 
ATOM   2106 H HG22 . THR A 1 135 ? -20.12895 -19.54103 9.80741   1.000 29.75219 ? 135 THR A HG22 1 
ATOM   2107 H HG23 . THR A 1 135 ? -21.04183 -18.79435 10.85700  1.000 29.75219 ? 135 THR A HG23 1 
ATOM   2108 N N    . ILE A 1 136 ? -17.49696 -21.15316 13.13576  1.000 20.14227 ? 136 ILE A N    1 
ATOM   2109 C CA   . ILE A 1 136 ? -16.38569 -21.32781 14.05017  1.000 20.23412 ? 136 ILE A CA   1 
ATOM   2110 C C    . ILE A 1 136 ? -15.14545 -20.73471 13.40354  1.000 20.69512 ? 136 ILE A C    1 
ATOM   2111 O O    . ILE A 1 136 ? -15.06932 -20.54022 12.18663  1.000 20.11743 ? 136 ILE A O    1 
ATOM   2112 C CB   . ILE A 1 136 ? -16.14935 -22.80256 14.46063  1.000 19.81850 ? 136 ILE A CB   1 
ATOM   2113 C CG1  . ILE A 1 136 ? -15.57123 -23.64069 13.32168  1.000 21.66092 ? 136 ILE A CG1  1 
ATOM   2114 C CG2  . ILE A 1 136 ? -17.45148 -23.41089 14.97759  1.000 20.84266 ? 136 ILE A CG2  1 
ATOM   2115 C CD1  . ILE A 1 136 ? -15.27093 -25.07817 13.72019  1.000 22.83229 ? 136 ILE A CD1  1 
ATOM   2116 H H    . ILE A 1 136 ? -17.33776 -21.42015 12.33390  1.000 24.22101 ? 136 ILE A H    1 
ATOM   2117 H HA   . ILE A 1 136 ? -16.57100 -20.84006 14.86788  1.000 24.33123 ? 136 ILE A HA   1 
ATOM   2118 H HB   . ILE A 1 136 ? -15.48690 -22.80510 15.16919  1.000 23.83249 ? 136 ILE A HB   1 
ATOM   2119 H HG12 . ILE A 1 136 ? -16.21059 -23.66157 12.59251  1.000 26.04340 ? 136 ILE A HG12 1 
ATOM   2120 H HG13 . ILE A 1 136 ? -14.74185 -23.23507 13.02418  1.000 26.04340 ? 136 ILE A HG13 1 
ATOM   2121 H HG21 . ILE A 1 136 ? -18.10627 -23.41038 14.26194  1.000 25.06148 ? 136 ILE A HG21 1 
ATOM   2122 H HG22 . ILE A 1 136 ? -17.28124 -24.32012 15.26952  1.000 25.06148 ? 136 ILE A HG22 1 
ATOM   2123 H HG23 . ILE A 1 136 ? -17.77463 -22.87951 15.72198  1.000 25.06148 ? 136 ILE A HG23 1 
ATOM   2124 H HD11 . ILE A 1 136 ? -14.77555 -25.50723 13.00506  1.000 27.44903 ? 136 ILE A HD11 1 
ATOM   2125 H HD12 . ILE A 1 136 ? -14.74275 -25.07657 14.53377  1.000 27.44903 ? 136 ILE A HD12 1 
ATOM   2126 H HD13 . ILE A 1 136 ? -16.10752 -25.54574 13.86986  1.000 27.44903 ? 136 ILE A HD13 1 
ATOM   2127 N N    . LYS A 1 137 ? -14.18478 -20.41029 14.24698  1.000 22.82845 ? 137 LYS A N    1 
ATOM   2128 C CA   . LYS A 1 137 ? -12.95137 -19.75391 13.83880  1.000 24.29782 ? 137 LYS A CA   1 
ATOM   2129 C C    . LYS A 1 137 ? -11.87851 -20.81273 14.03367  1.000 25.22176 ? 137 LYS A C    1 
ATOM   2130 O O    . LYS A 1 137 ? -11.31606 -20.96196 15.11963  1.000 25.04887 ? 137 LYS A O    1 
ATOM   2131 C CB   . LYS A 1 137 ? -12.69945 -18.48347 14.63910  1.000 28.68793 ? 137 LYS A CB   1 
ATOM   2132 C CG   . LYS A 1 137 ? -13.80790 -17.45073 14.44359  1.000 29.47170 ? 137 LYS A CG   1 
ATOM   2133 C CD   . LYS A 1 137 ? -13.50358 -16.08595 15.06750  1.000 43.97225 ? 137 LYS A CD   1 
ATOM   2134 C CE   . LYS A 1 137 ? -13.34861 -16.16181 16.58139  1.000 45.76392 ? 137 LYS A CE   1 
ATOM   2135 N NZ   . LYS A 1 137 ? -13.72847 -14.88330 17.25870  1.000 47.12788 ? 137 LYS A NZ   1 
ATOM   2136 H H    . LYS A 1 137 ? -14.22286 -20.56449 15.09218  1.000 27.44443 ? 137 LYS A H    1 
ATOM   2137 H HA   . LYS A 1 137 ? -12.97970 -19.47929 12.90892  1.000 29.20768 ? 137 LYS A HA   1 
ATOM   2138 H HB2  . LYS A 1 137 ? -12.65494 -18.70533 15.58234  1.000 34.47581 ? 137 LYS A HB2  1 
ATOM   2139 H HB3  . LYS A 1 137 ? -11.86203 -18.08727 14.35160  1.000 34.47581 ? 137 LYS A HB3  1 
ATOM   2140 H HG2  . LYS A 1 137 ? -13.94430 -17.31588 13.49274  1.000 35.41633 ? 137 LYS A HG2  1 
ATOM   2141 H HG3  . LYS A 1 137 ? -14.62178 -17.78585 14.85125  1.000 35.41633 ? 137 LYS A HG3  1 
ATOM   2142 H HD2  . LYS A 1 137 ? -12.67485 -15.74449 14.69667  1.000 52.81699 ? 137 LYS A HD2  1 
ATOM   2143 H HD3  . LYS A 1 137 ? -14.23166 -15.47636 14.86948  1.000 52.81699 ? 137 LYS A HD3  1 
ATOM   2144 H HE2  . LYS A 1 137 ? -13.92097 -16.86586 16.92434  1.000 54.96699 ? 137 LYS A HE2  1 
ATOM   2145 H HE3  . LYS A 1 137 ? -12.42230 -16.35293 16.79663  1.000 54.96699 ? 137 LYS A HE3  1 
ATOM   2146 H HZ1  . LYS A 1 137 ? -13.31469 -14.19809 16.86963  1.000 56.60374 ? 137 LYS A HZ1  1 
ATOM   2147 H HZ2  . LYS A 1 137 ? -14.60798 -14.75897 17.20303  1.000 56.60374 ? 137 LYS A HZ2  1 
ATOM   2148 H HZ3  . LYS A 1 137 ? -13.49462 -14.91234 18.11694  1.000 56.60374 ? 137 LYS A HZ3  1 
ATOM   2149 N N    . GLY A 1 138 ? -11.62618 -21.56983 12.98095  1.000 23.74289 ? 138 GLY A N    1 
ATOM   2150 C CA   . GLY A 1 138 ? -10.73279 -22.68608 13.10391  1.000 24.69139 ? 138 GLY A CA   1 
ATOM   2151 C C    . GLY A 1 138 ? -9.50328  -22.52084 12.25267  1.000 24.48570 ? 138 GLY A C    1 
ATOM   2152 O O    . GLY A 1 138 ? -9.11254  -21.41319 11.87096  1.000 25.49081 ? 138 GLY A O    1 
ATOM   2153 H H    . GLY A 1 138 ? -11.95947 -21.45335 12.19677  1.000 28.54176 ? 138 GLY A H    1 
ATOM   2154 H HA2  . GLY A 1 138 ? -10.45619 -22.77714 14.02916  1.000 29.67995 ? 138 GLY A HA2  1 
ATOM   2155 H HA3  . GLY A 1 138 ? -11.18992 -23.49649 12.82973  1.000 29.67995 ? 138 GLY A HA3  1 
ATOM   2156 N N    . SER A 1 139 ? -8.89905  -23.66418 11.95189  1.000 23.24765 ? 139 SER A N    1 
ATOM   2157 C CA   . SER A 1 139 ? -7.69366  -23.75514 11.14111  1.000 22.93625 ? 139 SER A CA   1 
ATOM   2158 C C    . SER A 1 139 ? -7.87023  -24.99955 10.27658  1.000 23.39544 ? 139 SER A C    1 
ATOM   2159 O O    . SER A 1 139 ? -7.68221  -26.11860 10.76054  1.000 21.39772 ? 139 SER A O    1 
ATOM   2160 C CB   . SER A 1 139 ? -6.45399  -23.84651 12.01453  1.000 25.26313 ? 139 SER A CB   1 
ATOM   2161 O OG   . SER A 1 139 ? -5.28346  -23.85967 11.22252  1.000 26.42155 ? 139 SER A OG   1 
ATOM   2162 H H    . SER A 1 139 ? -9.18064  -24.43223 12.21723  1.000 27.94747 ? 139 SER A H    1 
ATOM   2163 H HA   . SER A 1 139 ? -7.59782  -22.97529 10.57231  1.000 27.57379 ? 139 SER A HA   1 
ATOM   2164 H HB2  . SER A 1 139 ? -6.42678  -23.07831 12.60617  1.000 30.36605 ? 139 SER A HB2  1 
ATOM   2165 H HB3  . SER A 1 139 ? -6.49315  -24.66446 12.53445  1.000 30.36605 ? 139 SER A HB3  1 
ATOM   2166 H HG   . SER A 1 139 ? -5.25447  -23.17183 10.74124  1.000 31.75616 ? 139 SER A HG   1 
ATOM   2167 N N    . PHE A 1 140 ? -8.24326  -24.79916 9.01504   1.000 23.80727 ? 140 PHE A N    1 
ATOM   2168 C CA   . PHE A 1 140 ? -8.62857  -25.89647 8.13914   1.000 23.59175 ? 140 PHE A CA   1 
ATOM   2169 C C    . PHE A 1 140 ? -8.10886  -25.65172 6.73243   1.000 23.60060 ? 140 PHE A C    1 
ATOM   2170 O O    . PHE A 1 140 ? -8.33969  -24.57825 6.16925   1.000 24.51851 ? 140 PHE A O    1 
ATOM   2171 C CB   . PHE A 1 140 ? -10.15295 -26.04819 8.05059   1.000 22.39702 ? 140 PHE A CB   1 
ATOM   2172 C CG   . PHE A 1 140 ? -10.82447 -26.43609 9.33386   1.000 22.44868 ? 140 PHE A CG   1 
ATOM   2173 C CD1  . PHE A 1 140 ? -10.83169 -27.74767 9.76286   1.000 21.64738 ? 140 PHE A CD1  1 
ATOM   2174 C CD2  . PHE A 1 140 ? -11.50079 -25.49335 10.08111  1.000 21.72056 ? 140 PHE A CD2  1 
ATOM   2175 C CE1  . PHE A 1 140 ? -11.47639 -28.10445 10.93315  1.000 21.16936 ? 140 PHE A CE1  1 
ATOM   2176 C CE2  . PHE A 1 140 ? -12.14701 -25.84621 11.25144  1.000 21.17569 ? 140 PHE A CE2  1 
ATOM   2177 C CZ   . PHE A 1 140 ? -12.14411 -27.15082 11.67114  1.000 20.92472 ? 140 PHE A CZ   1 
ATOM   2178 H H    . PHE A 1 140 ? -8.28103  -24.02585 8.64065   1.000 28.61901 ? 140 PHE A H    1 
ATOM   2179 H HA   . PHE A 1 140 ? -8.23360  -26.70732 8.49611   1.000 28.36039 ? 140 PHE A HA   1 
ATOM   2180 H HB2  . PHE A 1 140 ? -10.53048 -25.20013 7.76921   1.000 26.92671 ? 140 PHE A HB2  1 
ATOM   2181 H HB3  . PHE A 1 140 ? -10.35605 -26.73509 7.39651   1.000 26.92671 ? 140 PHE A HB3  1 
ATOM   2182 H HD1  . PHE A 1 140 ? -10.39833 -28.39866 9.25955   1.000 26.02715 ? 140 PHE A HD1  1 
ATOM   2183 H HD2  . PHE A 1 140 ? -11.52218 -24.60912 9.79373   1.000 26.11497 ? 140 PHE A HD2  1 
ATOM   2184 H HE1  . PHE A 1 140 ? -11.45942 -28.98818 11.22235  1.000 25.45352 ? 140 PHE A HE1  1 
ATOM   2185 H HE2  . PHE A 1 140 ? -12.58415 -25.19748 11.75439  1.000 25.46112 ? 140 PHE A HE2  1 
ATOM   2186 H HZ   . PHE A 1 140 ? -12.59074 -27.39167 12.45051  1.000 25.15995 ? 140 PHE A HZ   1 
ATOM   2187 N N    . LEU A 1 141 ? -7.46879  -26.65934 6.15117   1.000 24.68742 ? 141 LEU A N    1 
ATOM   2188 C CA   . LEU A 1 141 ? -6.97682  -26.59841 4.78494   1.000 24.77558 ? 141 LEU A CA   1 
ATOM   2189 C C    . LEU A 1 141 ? -7.73542  -27.58350 3.89807   1.000 26.29708 ? 141 LEU A C    1 
ATOM   2190 O O    . LEU A 1 141 ? -8.56781  -28.36960 4.35754   1.000 22.10040 ? 141 LEU A O    1 
ATOM   2191 C CB   . LEU A 1 141 ? -5.47269  -26.90316 4.74319   1.000 24.60306 ? 141 LEU A CB   1 
ATOM   2192 C CG   . LEU A 1 141 ? -4.55991  -25.94680 5.51042   1.000 29.15141 ? 141 LEU A CG   1 
ATOM   2193 C CD1  . LEU A 1 141 ? -3.14535  -26.50697 5.57612   1.000 38.47713 ? 141 LEU A CD1  1 
ATOM   2194 C CD2  . LEU A 1 141 ? -4.56326  -24.56258 4.86859   1.000 31.75317 ? 141 LEU A CD2  1 
ATOM   2195 H H    . LEU A 1 141 ? -7.30423  -27.40816 6.54077   1.000 29.67519 ? 141 LEU A H    1 
ATOM   2196 H HA   . LEU A 1 141 ? -7.12380  -25.70527 4.43626   1.000 29.78099 ? 141 LEU A HA   1 
ATOM   2197 H HB2  . LEU A 1 141 ? -5.33528  -27.78821 5.11563   1.000 29.57396 ? 141 LEU A HB2  1 
ATOM   2198 H HB3  . LEU A 1 141 ? -5.18849  -26.88564 3.81592   1.000 29.57396 ? 141 LEU A HB3  1 
ATOM   2199 H HG   . LEU A 1 141 ? -4.89143  -25.85182 6.41705   1.000 35.03199 ? 141 LEU A HG   1 
ATOM   2200 H HD11 . LEU A 1 141 ? -2.82874  -26.45861 6.49172   1.000 46.22284 ? 141 LEU A HD11 1 
ATOM   2201 H HD12 . LEU A 1 141 ? -3.15712  -27.43012 5.27852   1.000 46.22284 ? 141 LEU A HD12 1 
ATOM   2202 H HD13 . LEU A 1 141 ? -2.57015  -25.98069 4.99899   1.000 46.22284 ? 141 LEU A HD13 1 
ATOM   2203 H HD21 . LEU A 1 141 ? -4.16165  -24.62199 3.98763   1.000 38.15409 ? 141 LEU A HD21 1 
ATOM   2204 H HD22 . LEU A 1 141 ? -5.47889  -24.25110 4.79438   1.000 38.15409 ? 141 LEU A HD22 1 
ATOM   2205 H HD23 . LEU A 1 141 ? -4.05132  -23.95514 5.42522   1.000 38.15409 ? 141 LEU A HD23 1 
ATOM   2206 N N    . ASN A 1 142 ? -7.43731  -27.53511 2.60663   1.000 27.50547 ? 142 ASN A N    1 
ATOM   2207 C CA   . ASN A 1 142 ? -7.90974  -28.58801 1.72586   1.000 26.91224 ? 142 ASN A CA   1 
ATOM   2208 C C    . ASN A 1 142 ? -7.54525  -29.93982 2.32612   1.000 25.87318 ? 142 ASN A C    1 
ATOM   2209 O O    . ASN A 1 142 ? -6.44622  -30.13130 2.84990   1.000 22.50272 ? 142 ASN A O    1 
ATOM   2210 C CB   . ASN A 1 142 ? -7.31721  -28.42666 0.33421   1.000 32.17871 ? 142 ASN A CB   1 
ATOM   2211 C CG   . ASN A 1 142 ? -7.86866  -27.21500 -0.37909  1.000 43.90652 ? 142 ASN A CG   1 
ATOM   2212 O OD1  . ASN A 1 142 ? -7.20399  -26.18493 -0.48600  1.000 51.72886 ? 142 ASN A OD1  1 
ATOM   2213 N ND2  . ASN A 1 142 ? -9.11138  -27.31634 -0.83679  1.000 47.11500 ? 142 ASN A ND2  1 
ATOM   2214 H H    . ASN A 1 142 ? -6.97443  -26.91807 2.22635   1.000 33.05685 ? 142 ASN A H    1 
ATOM   2215 H HA   . ASN A 1 142 ? -8.87333  -28.53932 1.62580   1.000 32.34498 ? 142 ASN A HA   1 
ATOM   2216 H HB2  . ASN A 1 142 ? -6.35544  -28.32380 0.40704   1.000 38.66474 ? 142 ASN A HB2  1 
ATOM   2217 H HB3  . ASN A 1 142 ? -7.52776  -29.21180 -0.19505  1.000 38.66474 ? 142 ASN A HB3  1 
ATOM   2218 H HD21 . ASN A 1 142 ? -9.47256  -26.65451 -1.25048  1.000 56.58829 ? 142 ASN A HD21 1 
ATOM   2219 H HD22 . ASN A 1 142 ? -9.55486  -28.04377 -0.71946  1.000 56.58829 ? 142 ASN A HD22 1 
ATOM   2220 N N    . GLY A 1 143 ? -8.50788  -30.85828 2.29553   1.000 24.70951 ? 143 GLY A N    1 
ATOM   2221 C CA   . GLY A 1 143 ? -8.33008  -32.17325 2.86321   1.000 23.90693 ? 143 GLY A CA   1 
ATOM   2222 C C    . GLY A 1 143 ? -8.75657  -32.32198 4.30846   1.000 22.69584 ? 143 GLY A C    1 
ATOM   2223 O O    . GLY A 1 143 ? -8.77414  -33.45154 4.81134   1.000 22.41451 ? 143 GLY A O    1 
ATOM   2224 H H    . GLY A 1 143 ? -9.28264  -30.73335 1.94378   1.000 29.70171 ? 143 GLY A H    1 
ATOM   2225 H HA2  . GLY A 1 143 ? -8.84426  -32.80718 2.33913   1.000 28.73860 ? 143 GLY A HA2  1 
ATOM   2226 H HA3  . GLY A 1 143 ? -7.39037  -32.40764 2.80928   1.000 28.73860 ? 143 GLY A HA3  1 
ATOM   2227 N N    . SER A 1 144 ? -9.11091  -31.22973 4.99764   1.000 22.12214 ? 144 SER A N    1 
ATOM   2228 C CA   . SER A 1 144 ? -9.47576  -31.30218 6.40494   1.000 22.25226 ? 144 SER A CA   1 
ATOM   2229 C C    . SER A 1 144 ? -10.93367 -31.68776 6.63875   1.000 20.22385 ? 144 SER A C    1 
ATOM   2230 O O    . SER A 1 144 ? -11.30091 -31.98307 7.78096   1.000 18.71422 ? 144 SER A O    1 
ATOM   2231 C CB   . SER A 1 144 ? -9.22135  -29.96208 7.09814   1.000 22.63572 ? 144 SER A CB   1 
ATOM   2232 O OG   . SER A 1 144 ? -10.04134 -28.95685 6.53356   1.000 21.33486 ? 144 SER A OG   1 
ATOM   2233 H H    . SER A 1 144 ? -9.14590  -30.43682 4.66648   1.000 26.59686 ? 144 SER A H    1 
ATOM   2234 H HA   . SER A 1 144 ? -8.91031  -31.97611 6.81358   1.000 26.75300 ? 144 SER A HA   1 
ATOM   2235 H HB2  . SER A 1 144 ? -9.42716  -30.04783 8.04217   1.000 27.21316 ? 144 SER A HB2  1 
ATOM   2236 H HB3  . SER A 1 144 ? -8.29033  -29.71557 6.98263   1.000 27.21316 ? 144 SER A HB3  1 
ATOM   2237 H HG   . SER A 1 144 ? -9.63317  -28.56999 5.90960   1.000 25.65213 ? 144 SER A HG   1 
ATOM   2238 N N    . CYS A 1 145 ? -11.76840 -31.68546 5.61041   1.000 20.73168 ? 145 CYS A N    1 
ATOM   2239 C CA   . CYS A 1 145 ? -13.17086 -32.01757 5.81292   1.000 20.36005 ? 145 CYS A CA   1 
ATOM   2240 C C    . CYS A 1 145 ? -13.31517 -33.42865 6.37532   1.000 19.15656 ? 145 CYS A C    1 
ATOM   2241 O O    . CYS A 1 145 ? -12.51967 -34.32674 6.08920   1.000 19.60554 ? 145 CYS A O    1 
ATOM   2242 C CB   . CYS A 1 145 ? -13.93819 -31.85816 4.50893   1.000 18.92887 ? 145 CYS A CB   1 
ATOM   2243 S SG   . CYS A 1 145 ? -14.21966 -30.11730 4.15636   1.000 20.57122 ? 145 CYS A SG   1 
ATOM   2244 H H    . CYS A 1 145 ? -11.55303 -31.49865 4.79904   1.000 24.92831 ? 145 CYS A H    1 
ATOM   2245 H HA   . CYS A 1 145 ? -13.56547 -31.41106 6.45892   1.000 24.48234 ? 145 CYS A HA   1 
ATOM   2246 H HB2  . CYS A 1 145 ? -13.42527 -32.24327 3.78126   1.000 22.76493 ? 145 CYS A HB2  1 
ATOM   2247 H HB3  . CYS A 1 145 ? -14.79710 -32.30306 4.58120   1.000 22.76493 ? 145 CYS A HB3  1 
ATOM   2248 N N    . GLY A 1 146 ? -14.33376 -33.60673 7.21376   1.000 20.07922 ? 146 GLY A N    1 
ATOM   2249 C CA   . GLY A 1 146 ? -14.49803 -34.81983 7.96888   1.000 20.59245 ? 146 GLY A CA   1 
ATOM   2250 C C    . GLY A 1 146 ? -13.82532 -34.80407 9.32266   1.000 18.00622 ? 146 GLY A C    1 
ATOM   2251 O O    . GLY A 1 146 ? -14.15771 -35.63750 10.17286  1.000 19.27206 ? 146 GLY A O    1 
ATOM   2252 H H    . GLY A 1 146 ? -14.94786 -33.02195 7.35699   1.000 24.14535 ? 146 GLY A H    1 
ATOM   2253 H HA2  . GLY A 1 146 ? -15.44519 -34.97614 8.10804   1.000 24.76123 ? 146 GLY A HA2  1 
ATOM   2254 H HA3  . GLY A 1 146 ? -14.12756 -35.55791 7.46007   1.000 24.76123 ? 146 GLY A HA3  1 
ATOM   2255 N N    . SER A 1 147 ? -12.87515 -33.90139 9.53990   1.000 17.65756 ? 147 SER A N    1 
ATOM   2256 C CA   . SER A 1 147 ? -12.46006 -33.58579 10.89869  1.000 19.45165 ? 147 SER A CA   1 
ATOM   2257 C C    . SER A 1 147 ? -13.68680 -33.28207 11.74858  1.000 19.45208 ? 147 SER A C    1 
ATOM   2258 O O    . SER A 1 147 ? -14.65418 -32.67853 11.27648  1.000 18.88868 ? 147 SER A O    1 
ATOM   2259 C CB   . SER A 1 147 ? -11.51614 -32.38090 10.90844  1.000 19.36584 ? 147 SER A CB   1 
ATOM   2260 O OG   . SER A 1 147 ? -10.32269 -32.63150 10.19235  1.000 20.90079 ? 147 SER A OG   1 
ATOM   2261 H H    . SER A 1 147 ? -12.46126 -33.46405 8.92587   1.000 21.23936 ? 147 SER A H    1 
ATOM   2262 H HA   . SER A 1 147 ? -11.98427 -34.34115 11.27810  1.000 23.39227 ? 147 SER A HA   1 
ATOM   2263 H HB2  . SER A 1 147 ? -11.97055 -31.62736 10.50029  1.000 23.28929 ? 147 SER A HB2  1 
ATOM   2264 H HB3  . SER A 1 147 ? -11.28837 -32.17253 11.82800  1.000 23.28929 ? 147 SER A HB3  1 
ATOM   2265 H HG   . SER A 1 147 ? -10.37512 -32.30092 9.42191   1.000 25.13123 ? 147 SER A HG   1 
ATOM   2266 N N    . VAL A 1 148 ? -13.62447 -33.67497 13.02563  1.000 19.41679 ? 148 VAL A N    1 
ATOM   2267 C CA   . VAL A 1 148 ? -14.77988 -33.58520 13.91067  1.000 17.63294 ? 148 VAL A CA   1 
ATOM   2268 C C    . VAL A 1 148 ? -14.45015 -32.77214 15.15581  1.000 21.93960 ? 148 VAL A C    1 
ATOM   2269 O O    . VAL A 1 148 ? -13.29446 -32.60446 15.55275  1.000 20.62622 ? 148 VAL A O    1 
ATOM   2270 C CB   . VAL A 1 148 ? -15.29472 -34.98106 14.31247  1.000 19.25855 ? 148 VAL A CB   1 
ATOM   2271 C CG1  . VAL A 1 148 ? -15.73977 -35.70997 13.08131  1.000 20.88296 ? 148 VAL A CG1  1 
ATOM   2272 C CG2  . VAL A 1 148 ? -14.21882 -35.77455 15.04645  1.000 20.65680 ? 148 VAL A CG2  1 
ATOM   2273 H H    . VAL A 1 148 ? -12.91985 -33.99716 13.39888  1.000 23.35044 ? 148 VAL A H    1 
ATOM   2274 H HA   . VAL A 1 148 ? -15.47669 -33.10247 13.43914  1.000 21.20982 ? 148 VAL A HA   1 
ATOM   2275 H HB   . VAL A 1 148 ? -16.04500 -34.88556 14.91982  1.000 23.16055 ? 148 VAL A HB   1 
ATOM   2276 H HG11 . VAL A 1 148 ? -16.35660 -35.14771 12.58706  1.000 25.10984 ? 148 VAL A HG11 1 
ATOM   2277 H HG12 . VAL A 1 148 ? -14.96374 -35.90975 12.53472  1.000 25.10984 ? 148 VAL A HG12 1 
ATOM   2278 H HG13 . VAL A 1 148 ? -16.18038 -36.53332 13.34370  1.000 25.10984 ? 148 VAL A HG13 1 
ATOM   2279 H HG21 . VAL A 1 148 ? -13.41648 -35.23333 15.11163  1.000 24.83845 ? 148 VAL A HG21 1 
ATOM   2280 H HG22 . VAL A 1 148 ? -14.54075 -35.99704 15.93401  1.000 24.83845 ? 148 VAL A HG22 1 
ATOM   2281 H HG23 . VAL A 1 148 ? -14.03086 -36.58620 14.54966  1.000 24.83845 ? 148 VAL A HG23 1 
ATOM   2282 N N    . GLY A 1 149 ? -15.51140 -32.23773 15.75200  1.000 19.90606 ? 149 GLY A N    1 
ATOM   2283 C CA   . GLY A 1 149 ? -15.44013 -31.53874 17.01981  1.000 20.66669 ? 149 GLY A CA   1 
ATOM   2284 C C    . GLY A 1 149 ? -16.20302 -32.33077 18.06296  1.000 21.30972 ? 149 GLY A C    1 
ATOM   2285 O O    . GLY A 1 149 ? -17.18336 -33.00975 17.75200  1.000 21.40406 ? 149 GLY A O    1 
ATOM   2286 H H    . GLY A 1 149 ? -16.30704 -32.27072 15.42723  1.000 23.93756 ? 149 GLY A H    1 
ATOM   2287 H HA2  . GLY A 1 149 ? -14.51602 -31.44772 17.30021  1.000 24.85031 ? 149 GLY A HA2  1 
ATOM   2288 H HA3  . GLY A 1 149 ? -15.83366 -30.65596 16.93775  1.000 24.85031 ? 149 GLY A HA3  1 
ATOM   2289 N N    . PHE A 1 150 ? -15.73920 -32.25448 19.30619  1.000 21.72769 ? 150 PHE A N    1 
ATOM   2290 C CA   . PHE A 1 150 ? -16.28591 -33.12983 20.33060  1.000 22.96971 ? 150 PHE A CA   1 
ATOM   2291 C C    . PHE A 1 150 ? -16.08855 -32.52809 21.70904  1.000 25.21221 ? 150 PHE A C    1 
ATOM   2292 O O    . PHE A 1 150 ? -15.25472 -31.64334 21.91932  1.000 23.80465 ? 150 PHE A O    1 
ATOM   2293 C CB   . PHE A 1 150 ? -15.61763 -34.50974 20.28947  1.000 23.13510 ? 150 PHE A CB   1 
ATOM   2294 C CG   . PHE A 1 150 ? -14.13457 -34.44418 20.49651  1.000 22.28471 ? 150 PHE A CG   1 
ATOM   2295 C CD1  . PHE A 1 150 ? -13.30063 -34.06561 19.45899  1.000 22.91452 ? 150 PHE A CD1  1 
ATOM   2296 C CD2  . PHE A 1 150 ? -13.57520 -34.73816 21.72636  1.000 24.22984 ? 150 PHE A CD2  1 
ATOM   2297 C CE1  . PHE A 1 150 ? -11.93429 -33.98277 19.64301  1.000 23.54288 ? 150 PHE A CE1  1 
ATOM   2298 C CE2  . PHE A 1 150 ? -12.21500 -34.66364 21.91629  1.000 24.54054 ? 150 PHE A CE2  1 
ATOM   2299 C CZ   . PHE A 1 150 ? -11.38953 -34.28158 20.87278  1.000 24.25517 ? 150 PHE A CZ   1 
ATOM   2300 H H    . PHE A 1 150 ? -15.12340 -31.71668 19.57296  1.000 26.12351 ? 150 PHE A H    1 
ATOM   2301 H HA   . PHE A 1 150 ? -17.23953 -33.21109 20.17279  1.000 27.61394 ? 150 PHE A HA   1 
ATOM   2302 H HB2  . PHE A 1 150 ? -15.99426 -35.06366 20.99105  1.000 27.81241 ? 150 PHE A HB2  1 
ATOM   2303 H HB3  . PHE A 1 150 ? -15.78200 -34.91414 19.42325  1.000 27.81241 ? 150 PHE A HB3  1 
ATOM   2304 H HD1  . PHE A 1 150 ? -13.66487 -33.86441 18.62728  1.000 27.54772 ? 150 PHE A HD1  1 
ATOM   2305 H HD2  . PHE A 1 150 ? -14.12497 -34.98915 22.43322  1.000 29.12610 ? 150 PHE A HD2  1 
ATOM   2306 H HE1  . PHE A 1 150 ? -11.38360 -33.72606 18.93892  1.000 28.30175 ? 150 PHE A HE1  1 
ATOM   2307 H HE2  . PHE A 1 150 ? -11.84965 -34.87004 22.74625  1.000 29.49894 ? 150 PHE A HE2  1 
ATOM   2308 H HZ   . PHE A 1 150 ? -10.47010 -34.22678 21.00140  1.000 29.15650 ? 150 PHE A HZ   1 
ATOM   2309 N N    . ASN A 1 151 ? -16.85449 -33.05481 22.65220  1.000 24.26642 ? 151 ASN A N    1 
ATOM   2310 C CA   . ASN A 1 151 ? -16.64158 -32.86263 24.07144  1.000 27.05387 ? 151 ASN A CA   1 
ATOM   2311 C C    . ASN A 1 151 ? -16.51134 -34.23500 24.71562  1.000 30.20734 ? 151 ASN A C    1 
ATOM   2312 O O    . ASN A 1 151 ? -16.99012 -35.23607 24.17706  1.000 28.57355 ? 151 ASN A O    1 
ATOM   2313 C CB   . ASN A 1 151 ? -17.79665 -32.08875 24.70822  1.000 27.90420 ? 151 ASN A CB   1 
ATOM   2314 C CG   . ASN A 1 151 ? -17.76531 -30.61406 24.37178  1.000 28.33303 ? 151 ASN A CG   1 
ATOM   2315 O OD1  . ASN A 1 151 ? -18.41962 -30.16059 23.43331  1.000 27.59528 ? 151 ASN A OD1  1 
ATOM   2316 N ND2  . ASN A 1 151 ? -17.00853 -29.85221 25.15178  1.000 27.78471 ? 151 ASN A ND2  1 
ATOM   2317 H H    . ASN A 1 151 ? -17.53626 -33.55110 22.48344  1.000 29.16999 ? 151 ASN A H    1 
ATOM   2318 H HA   . ASN A 1 151 ? -15.83130 -32.35357 24.23022  1.000 32.51494 ? 151 ASN A HA   1 
ATOM   2319 H HB2  . ASN A 1 151 ? -18.63651 -32.45241 24.38686  1.000 33.53533 ? 151 ASN A HB2  1 
ATOM   2320 H HB3  . ASN A 1 151 ? -17.74384 -32.17804 25.67265  1.000 33.53533 ? 151 ASN A HB3  1 
ATOM   2321 H HD21 . ASN A 1 151 ? -16.95461 -29.00653 25.00514  1.000 33.39195 ? 151 ASN A HD21 1 
ATOM   2322 H HD22 . ASN A 1 151 ? -16.57207 -30.20425 25.80383  1.000 33.39195 ? 151 ASN A HD22 1 
ATOM   2323 N N    . ILE A 1 152 ? -15.85923 -34.29207 25.86820  1.000 30.16565 ? 152 ILE A N    1 
ATOM   2324 C CA   . ILE A 1 152 ? -15.80306 -35.51258 26.66333  1.000 34.39061 ? 152 ILE A CA   1 
ATOM   2325 C C    . ILE A 1 152 ? -16.39449 -35.18595 28.02646  1.000 39.23841 ? 152 ILE A C    1 
ATOM   2326 O O    . ILE A 1 152 ? -16.14054 -34.10964 28.58016  1.000 35.21943 ? 152 ILE A O    1 
ATOM   2327 C CB   . ILE A 1 152 ? -14.36928 -36.06354 26.76698  1.000 33.19708 ? 152 ILE A CB   1 
ATOM   2328 C CG1  . ILE A 1 152 ? -13.71610 -36.05080 25.37957  1.000 31.08634 ? 152 ILE A CG1  1 
ATOM   2329 C CG2  . ILE A 1 152 ? -14.36460 -37.50175 27.27164  1.000 35.95521 ? 152 ILE A CG2  1 
ATOM   2330 C CD1  . ILE A 1 152 ? -12.37999 -36.73687 25.30164  1.000 35.52369 ? 152 ILE A CD1  1 
ATOM   2331 H H    . ILE A 1 152 ? -15.43601 -33.62876 26.21532  1.000 36.24907 ? 152 ILE A H    1 
ATOM   2332 H HA   . ILE A 1 152 ? -16.34263 -36.20830 26.25620  1.000 41.31903 ? 152 ILE A HA   1 
ATOM   2333 H HB   . ILE A 1 152 ? -13.88320 -35.50035 27.38944  1.000 39.88678 ? 152 ILE A HB   1 
ATOM   2334 H HG12 . ILE A 1 152 ? -14.30971 -36.49806 24.75629  1.000 37.35389 ? 152 ILE A HG12 1 
ATOM   2335 H HG13 . ILE A 1 152 ? -13.58573 -35.12826 25.10972  1.000 37.35389 ? 152 ILE A HG13 1 
ATOM   2336 H HG21 . ILE A 1 152 ? -14.60342 -38.09354 26.54112  1.000 43.19654 ? 152 ILE A HG21 1 
ATOM   2337 H HG22 . ILE A 1 152 ? -13.47709 -37.71938 27.59701  1.000 43.19654 ? 152 ILE A HG22 1 
ATOM   2338 H HG23 . ILE A 1 152 ? -15.01039 -37.58630 27.99047  1.000 43.19654 ? 152 ILE A HG23 1 
ATOM   2339 H HD11 . ILE A 1 152 ? -12.52030 -37.69335 25.22192  1.000 42.67871 ? 152 ILE A HD11 1 
ATOM   2340 H HD12 . ILE A 1 152 ? -11.90044 -36.40708 24.52564  1.000 42.67871 ? 152 ILE A HD12 1 
ATOM   2341 H HD13 . ILE A 1 152 ? -11.87758 -36.54235 26.10826  1.000 42.67871 ? 152 ILE A HD13 1 
ATOM   2342 N N    . ASP A 1 153 ? -17.25493 -36.07041 28.51520  1.000 44.51010 ? 153 ASP A N    1 
ATOM   2343 C CA   . ASP A 1 153 ? -17.74161 -36.04616 29.89360  1.000 45.79253 ? 153 ASP A CA   1 
ATOM   2344 C C    . ASP A 1 153 ? -17.32544 -37.38502 30.49910  1.000 46.82645 ? 153 ASP A C    1 
ATOM   2345 O O    . ASP A 1 153 ? -17.96771 -38.41239 30.25368  1.000 44.07454 ? 153 ASP A O    1 
ATOM   2346 C CB   . ASP A 1 153 ? -19.24713 -35.81670 29.95189  1.000 51.92602 ? 153 ASP A CB   1 
ATOM   2347 C CG   . ASP A 1 153 ? -19.76013 -35.63828 31.37406  1.000 63.26361 ? 153 ASP A CG   1 
ATOM   2348 O OD1  . ASP A 1 153 ? -19.01545 -35.95433 32.32596  1.000 66.34879 ? 153 ASP A OD1  1 
ATOM   2349 O OD2  . ASP A 1 153 ? -20.91023 -35.17728 31.54161  1.000 74.11520 ? 153 ASP A OD2  1 
ATOM   2350 H H    . ASP A 1 153 ? -17.58363 -36.71705 28.05324  1.000 53.46241 ? 153 ASP A H    1 
ATOM   2351 H HA   . ASP A 1 153 ? -17.33309 -35.32343 30.39527  1.000 55.00132 ? 153 ASP A HA   1 
ATOM   2352 H HB2  . ASP A 1 153 ? -19.46435 -35.01451 29.45168  1.000 62.36152 ? 153 ASP A HB2  1 
ATOM   2353 H HB3  . ASP A 1 153 ? -19.69896 -36.58225 29.56373  1.000 62.36152 ? 153 ASP A HB3  1 
ATOM   2354 N N    . TYR A 1 154 ? -16.23482 -37.37248 31.26735  1.000 49.28778 ? 154 TYR A N    1 
ATOM   2355 C CA   . TYR A 1 154 ? -15.65052 -38.57830 31.84460  1.000 53.70536 ? 154 TYR A CA   1 
ATOM   2356 C C    . TYR A 1 154 ? -15.25396 -39.57764 30.76401  1.000 45.98171 ? 154 TYR A C    1 
ATOM   2357 O O    . TYR A 1 154 ? -14.16302 -39.48006 30.19106  1.000 44.97438 ? 154 TYR A O    1 
ATOM   2358 C CB   . TYR A 1 154 ? -16.61617 -39.23178 32.83846  1.000 41.66211 ? 154 TYR A CB   1 
ATOM   2359 H H    . TYR A 1 154 ? -15.80419 -36.65722 31.47364  1.000 59.19563 ? 154 TYR A H    1 
ATOM   2360 H HA   . TYR A 1 154 ? -14.84737 -38.32447 32.32566  1.000 64.49673 ? 154 TYR A HA   1 
ATOM   2361 N N    . ASP A 1 155 ? -16.12162 -40.54825 30.48509  1.000 45.32039 ? 155 ASP A N    1 
ATOM   2362 C CA   . ASP A 1 155 ? -15.79778 -41.63104 29.56682  1.000 49.51135 ? 155 ASP A CA   1 
ATOM   2363 C C    . ASP A 1 155 ? -16.43829 -41.47078 28.19702  1.000 43.26088 ? 155 ASP A C    1 
ATOM   2364 O O    . ASP A 1 155 ? -16.02899 -42.15858 27.25541  1.000 44.07480 ? 155 ASP A O    1 
ATOM   2365 C CB   . ASP A 1 155 ? -16.23337 -42.97692 30.16626  1.000 50.90246 ? 155 ASP A CB   1 
ATOM   2366 H H    . ASP A 1 155 ? -16.91205 -40.59998 30.81997  1.000 54.43476 ? 155 ASP A H    1 
ATOM   2367 H HA   . ASP A 1 155 ? -14.83591 -41.65035 29.44296  1.000 59.46391 ? 155 ASP A HA   1 
ATOM   2368 N N    . CYS A 1 156 ? -17.41033 -40.57847 28.06028  1.000 37.20832 ? 156 CYS A N    1 
ATOM   2369 C CA   . CYS A 1 156 ? -18.26798 -40.52434 26.88710  1.000 32.74518 ? 156 CYS A CA   1 
ATOM   2370 C C    . CYS A 1 156 ? -17.88267 -39.36944 25.97556  1.000 32.13712 ? 156 CYS A C    1 
ATOM   2371 O O    . CYS A 1 156 ? -17.82735 -38.21808 26.41443  1.000 33.32315 ? 156 CYS A O    1 
ATOM   2372 C CB   . CYS A 1 156 ? -19.72998 -40.37930 27.31890  1.000 32.95921 ? 156 CYS A CB   1 
ATOM   2373 S SG   . CYS A 1 156 ? -20.86654 -40.41058 25.93792  1.000 35.10993 ? 156 CYS A SG   1 
ATOM   2374 H H    . CYS A 1 156 ? -17.59622 -39.97962 28.64886  1.000 44.70028 ? 156 CYS A H    1 
ATOM   2375 H HA   . CYS A 1 156 ? -18.15437 -41.34153 26.37701  1.000 39.34451 ? 156 CYS A HA   1 
ATOM   2376 H HB2  . CYS A 1 156 ? -19.95789 -41.11213 27.91213  1.000 39.60134 ? 156 CYS A HB2  1 
ATOM   2377 H HB3  . CYS A 1 156 ? -19.84035 -39.53287 27.77964  1.000 39.60134 ? 156 CYS A HB3  1 
ATOM   2378 H HG   . CYS A 1 156 ? -21.98463 -40.26544 26.34877  1.000 42.18220 ? 156 CYS A HG   1 
ATOM   2379 N N    . VAL A 1 157 ? -17.63594 -39.68105 24.70298  1.000 30.95037 ? 157 VAL A N    1 
ATOM   2380 C CA   . VAL A 1 157 ? -17.35468 -38.66887 23.69099  1.000 27.93656 ? 157 VAL A CA   1 
ATOM   2381 C C    . VAL A 1 157 ? -18.67375 -38.24205 23.06217  1.000 26.80744 ? 157 VAL A C    1 
ATOM   2382 O O    . VAL A 1 157 ? -19.37242 -39.06042 22.45585  1.000 27.53027 ? 157 VAL A O    1 
ATOM   2383 C CB   . VAL A 1 157 ? -16.39456 -39.19692 22.61344  1.000 25.60079 ? 157 VAL A CB   1 
ATOM   2384 C CG1  . VAL A 1 157 ? -16.05749 -38.09227 21.60049  1.000 25.85820 ? 157 VAL A CG1  1 
ATOM   2385 C CG2  . VAL A 1 157 ? -15.14656 -39.75004 23.25104  1.000 28.51738 ? 157 VAL A CG2  1 
ATOM   2386 H H    . VAL A 1 157 ? -17.62619 -40.48531 24.39856  1.000 37.19074 ? 157 VAL A H    1 
ATOM   2387 H HA   . VAL A 1 157 ? -16.94459 -37.90194 24.12059  1.000 33.57417 ? 157 VAL A HA   1 
ATOM   2388 H HB   . VAL A 1 157 ? -16.82678 -39.91731 22.12855  1.000 30.77124 ? 157 VAL A HB   1 
ATOM   2389 H HG11 . VAL A 1 157 ? -15.34520 -38.40284 21.01989  1.000 31.08013 ? 157 VAL A HG11 1 
ATOM   2390 H HG12 . VAL A 1 157 ? -16.84860 -37.89278 21.07586  1.000 31.08013 ? 157 VAL A HG12 1 
ATOM   2391 H HG13 . VAL A 1 157 ? -15.77078 -37.29994 22.08102  1.000 31.08013 ? 157 VAL A HG13 1 
ATOM   2392 H HG21 . VAL A 1 157 ? -14.50435 -39.96260 22.55585  1.000 34.27114 ? 157 VAL A HG21 1 
ATOM   2393 H HG22 . VAL A 1 157 ? -14.77636 -39.08361 23.85080  1.000 34.27114 ? 157 VAL A HG22 1 
ATOM   2394 H HG23 . VAL A 1 157 ? -15.37421 -40.55174 23.74739  1.000 34.27114 ? 157 VAL A HG23 1 
ATOM   2395 N N    . SER A 1 158 ? -19.01658 -36.96768 23.20759  1.000 27.30812 ? 158 SER A N    1 
ATOM   2396 C CA   . SER A 1 158 ? -20.18439 -36.39255 22.54900  1.000 27.51979 ? 158 SER A CA   1 
ATOM   2397 C C    . SER A 1 158 ? -19.67280 -35.68470 21.30366  1.000 25.76102 ? 158 SER A C    1 
ATOM   2398 O O    . SER A 1 158 ? -19.08054 -34.60560 21.39395  1.000 25.08578 ? 158 SER A O    1 
ATOM   2399 C CB   . SER A 1 158 ? -20.92833 -35.42295 23.46043  1.000 28.88669 ? 158 SER A CB   1 
ATOM   2400 O OG   . SER A 1 158 ? -21.46252 -36.08707 24.58642  1.000 38.25167 ? 158 SER A OG   1 
ATOM   2401 H H    . SER A 1 158 ? -18.58075 -36.40582 23.69130  1.000 32.82004 ? 158 SER A H    1 
ATOM   2402 H HA   . SER A 1 158 ? -20.80127 -37.10050 22.30575  1.000 33.07404 ? 158 SER A HA   1 
ATOM   2403 H HB2  . SER A 1 158 ? -20.31043 -34.73911 23.76286  1.000 34.71431 ? 158 SER A HB2  1 
ATOM   2404 H HB3  . SER A 1 158 ? -21.65431 -35.01689 22.96146  1.000 34.71431 ? 158 SER A HB3  1 
ATOM   2405 H HG   . SER A 1 158 ? -21.95192 -35.56284 25.02375  1.000 45.95230 ? 158 SER A HG   1 
ATOM   2406 N N    . PHE A 1 159 ? -19.87634 -36.29545 20.14409  1.000 24.51182 ? 159 PHE A N    1 
ATOM   2407 C CA   . PHE A 1 159 ? -19.49245 -35.65800 18.89695  1.000 24.58278 ? 159 PHE A CA   1 
ATOM   2408 C C    . PHE A 1 159 ? -20.55069 -34.63559 18.51966  1.000 24.82881 ? 159 PHE A C    1 
ATOM   2409 O O    . PHE A 1 159 ? -21.74646 -34.94294 18.53500  1.000 24.10508 ? 159 PHE A O    1 
ATOM   2410 C CB   . PHE A 1 159 ? -19.35602 -36.67952 17.77689  1.000 23.13148 ? 159 PHE A CB   1 
ATOM   2411 C CG   . PHE A 1 159 ? -18.26764 -37.68149 17.99307  1.000 22.28528 ? 159 PHE A CG   1 
ATOM   2412 C CD1  . PHE A 1 159 ? -16.95504 -37.37198 17.68377  1.000 20.86932 ? 159 PHE A CD1  1 
ATOM   2413 C CD2  . PHE A 1 159 ? -18.55707 -38.94259 18.48670  1.000 23.14524 ? 159 PHE A CD2  1 
ATOM   2414 C CE1  . PHE A 1 159 ? -15.94289 -38.30330 17.86705  1.000 20.81235 ? 159 PHE A CE1  1 
ATOM   2415 C CE2  . PHE A 1 159 ? -17.55223 -39.87726 18.68035  1.000 23.39300 ? 159 PHE A CE2  1 
ATOM   2416 C CZ   . PHE A 1 159 ? -16.24343 -39.56035 18.36420  1.000 22.40106 ? 159 PHE A CZ   1 
ATOM   2417 H H    . PHE A 1 159 ? -20.23235 -37.07323 20.05512  1.000 29.46448 ? 159 PHE A H    1 
ATOM   2418 H HA   . PHE A 1 159 ? -18.63366 -35.22160 19.01063  1.000 29.54963 ? 159 PHE A HA   1 
ATOM   2419 H HB2  . PHE A 1 159 ? -20.19174 -37.16528 17.69620  1.000 27.80806 ? 159 PHE A HB2  1 
ATOM   2420 H HB3  . PHE A 1 159 ? -19.16406 -36.20996 16.95011  1.000 27.80806 ? 159 PHE A HB3  1 
ATOM   2421 H HD1  . PHE A 1 159 ? -16.74859 -36.52929 17.34888  1.000 25.09348 ? 159 PHE A HD1  1 
ATOM   2422 H HD2  . PHE A 1 159 ? -19.43670 -39.16507 18.69081  1.000 27.82457 ? 159 PHE A HD2  1 
ATOM   2423 H HE1  . PHE A 1 159 ? -15.06411 -38.08364 17.65635  1.000 25.02510 ? 159 PHE A HE1  1 
ATOM   2424 H HE2  . PHE A 1 159 ? -17.75782 -40.71715 19.02270  1.000 28.12189 ? 159 PHE A HE2  1 
ATOM   2425 H HZ   . PHE A 1 159 ? -15.56843 -40.18859 18.48496  1.000 26.93156 ? 159 PHE A HZ   1 
ATOM   2426 N N    . CYS A 1 160 ? -20.12195 -33.43363 18.15697  1.000 21.89008 ? 160 CYS A N    1 
ATOM   2427 C CA   . CYS A 1 160 ? -21.08584 -32.40292 17.82103  1.000 21.85140 ? 160 CYS A CA   1 
ATOM   2428 C C    . CYS A 1 160 ? -20.84836 -31.69144 16.49671  1.000 21.08113 ? 160 CYS A C    1 
ATOM   2429 O O    . CYS A 1 160 ? -21.74097 -30.95214 16.06725  1.000 21.91360 ? 160 CYS A O    1 
ATOM   2430 C CB   . CYS A 1 160 ? -21.13198 -31.34057 18.93419  1.000 23.16575 ? 160 CYS A CB   1 
ATOM   2431 S SG   . CYS A 1 160 ? -19.54423 -30.52172 19.23760  1.000 23.32425 ? 160 CYS A SG   1 
ATOM   2432 H H    . CYS A 1 160 ? -19.29662 -33.19872 18.09996  1.000 26.31839 ? 160 CYS A H    1 
ATOM   2433 H HA   . CYS A 1 160 ? -21.95475 -32.82919 17.75629  1.000 26.27198 ? 160 CYS A HA   1 
ATOM   2434 H HB2  . CYS A 1 160 ? -21.77376 -30.65719 18.68518  1.000 27.84919 ? 160 CYS A HB2  1 
ATOM   2435 H HB3  . CYS A 1 160 ? -21.40636 -31.76804 19.76056  1.000 27.84919 ? 160 CYS A HB3  1 
ATOM   2436 H HG   . CYS A 1 160 ? -18.76462 -31.32739 19.66551  1.000 28.03939 ? 160 CYS A HG   1 
ATOM   2437 N N    . TYR A 1 161 ? -19.70819 -31.88610 15.83587  1.000 19.84544 ? 161 TYR A N    1 
ATOM   2438 C CA   . TYR A 1 161 ? -19.37343 -31.09338 14.65508  1.000 19.90114 ? 161 TYR A CA   1 
ATOM   2439 C C    . TYR A 1 161 ? -18.59415 -31.95682 13.68553  1.000 17.75965 ? 161 TYR A C    1 
ATOM   2440 O O    . TYR A 1 161 ? -17.73276 -32.73660 14.09953  1.000 19.40419 ? 161 TYR A O    1 
ATOM   2441 C CB   . TYR A 1 161 ? -18.51927 -29.86316 15.01028  1.000 18.74782 ? 161 TYR A CB   1 
ATOM   2442 C CG   . TYR A 1 161 ? -18.08069 -28.99160 13.83209  1.000 18.91738 ? 161 TYR A CG   1 
ATOM   2443 C CD1  . TYR A 1 161 ? -18.90006 -27.98125 13.36303  1.000 18.44642 ? 161 TYR A CD1  1 
ATOM   2444 C CD2  . TYR A 1 161 ? -16.84057 -29.15657 13.22142  1.000 18.06809 ? 161 TYR A CD2  1 
ATOM   2445 C CE1  . TYR A 1 161 ? -18.51910 -27.18315 12.30393  1.000 19.13988 ? 161 TYR A CE1  1 
ATOM   2446 C CE2  . TYR A 1 161 ? -16.45036 -28.35566 12.16097  1.000 18.08243 ? 161 TYR A CE2  1 
ATOM   2447 C CZ   . TYR A 1 161 ? -17.29361 -27.36822 11.71015  1.000 17.67786 ? 161 TYR A CZ   1 
ATOM   2448 O OH   . TYR A 1 161 ? -16.91675 -26.56277 10.65635  1.000 19.49674 ? 161 TYR A OH   1 
ATOM   2449 H H    . TYR A 1 161 ? -19.11415 -32.46951 16.05119  1.000 23.86482 ? 161 TYR A H    1 
ATOM   2450 H HA   . TYR A 1 161 ? -20.19733 -30.79664 14.23790  1.000 23.93166 ? 161 TYR A HA   1 
ATOM   2451 H HB2  . TYR A 1 161 ? -19.03366 -29.29901 15.60863  1.000 22.54768 ? 161 TYR A HB2  1 
ATOM   2452 H HB3  . TYR A 1 161 ? -17.71397 -30.17091 15.45490  1.000 22.54768 ? 161 TYR A HB3  1 
ATOM   2453 H HD1  . TYR A 1 161 ? -19.72403 -27.83685 13.76939  1.000 22.18600 ? 161 TYR A HD1  1 
ATOM   2454 H HD2  . TYR A 1 161 ? -16.26346 -29.81677 13.53125  1.000 21.73200 ? 161 TYR A HD2  1 
ATOM   2455 H HE1  . TYR A 1 161 ? -19.09161 -26.52000 11.99190  1.000 23.01814 ? 161 TYR A HE1  1 
ATOM   2456 H HE2  . TYR A 1 161 ? -15.62301 -28.48515 11.75647  1.000 21.74921 ? 161 TYR A HE2  1 
ATOM   2457 H HH   . TYR A 1 161 ? -16.30230 -26.04316 10.89732  1.000 23.44638 ? 161 TYR A HH   1 
ATOM   2458 N N    . MET A 1 162 ? -18.88348 -31.79402 12.39258  1.000 17.49034 ? 162 MET A N    1 
ATOM   2459 C CA   . MET A 1 162 ? -18.05006 -32.33502 11.33177  1.000 19.29863 ? 162 MET A CA   1 
ATOM   2460 C C    . MET A 1 162 ? -17.78838 -31.23338 10.31310  1.000 19.68717 ? 162 MET A C    1 
ATOM   2461 O O    . MET A 1 162 ? -18.71066 -30.50694 9.91698   1.000 18.72430 ? 162 MET A O    1 
ATOM   2462 C CB   . MET A 1 162 ? -18.68835 -33.54590 10.65522  1.000 18.22715 ? 162 MET A CB   1 
ATOM   2463 C CG   . MET A 1 162 ? -17.88306 -34.05356 9.47019   1.000 20.85643 ? 162 MET A CG   1 
ATOM   2464 S SD   . MET A 1 162 ? -18.38535 -35.67004 8.82708   1.000 24.87068 ? 162 MET A SD   1 
ATOM   2465 C CE   . MET A 1 162 ? -17.48437 -36.78790 9.90430   1.000 21.56752 ? 162 MET A CE   1 
ATOM   2466 H H    . MET A 1 162 ? -19.57137 -31.36499 12.10562  1.000 21.03870 ? 162 MET A H    1 
ATOM   2467 H HA   . MET A 1 162 ? -17.20985 -32.63448 11.71292  1.000 23.20864 ? 162 MET A HA   1 
ATOM   2468 H HB2  . MET A 1 162 ? -18.75906 -34.26662 11.30055  1.000 21.92286 ? 162 MET A HB2  1 
ATOM   2469 H HB3  . MET A 1 162 ? -19.57022 -33.29957 10.33503  1.000 21.92286 ? 162 MET A HB3  1 
ATOM   2470 H HG2  . MET A 1 162 ? -17.96931 -33.41477 8.74534   1.000 25.07801 ? 162 MET A HG2  1 
ATOM   2471 H HG3  . MET A 1 162 ? -16.95411 -34.12590 9.73987   1.000 25.07801 ? 162 MET A HG3  1 
ATOM   2472 H HE1  . MET A 1 162 ? -17.79930 -36.67181 10.81438  1.000 25.93132 ? 162 MET A HE1  1 
ATOM   2473 H HE2  . MET A 1 162 ? -17.64031 -37.70026 9.61417   1.000 25.93132 ? 162 MET A HE2  1 
ATOM   2474 H HE3  . MET A 1 162 ? -16.53794 -36.58166 9.85294   1.000 25.93132 ? 162 MET A HE3  1 
ATOM   2475 N N    . HIS A 1 163 ? -16.54186 -31.12385 9.89567   1.000 18.96412 ? 163 HIS A N    1 
ATOM   2476 C CA   . HIS A 1 163 ? -16.15032 -29.97078 9.12186   1.000 19.65443 ? 163 HIS A CA   1 
ATOM   2477 C C    . HIS A 1 163 ? -16.43875 -30.14320 7.63329   1.000 19.33039 ? 163 HIS A C    1 
ATOM   2478 O O    . HIS A 1 163 ? -16.09222 -31.16323 7.03277   1.000 19.92341 ? 163 HIS A O    1 
ATOM   2479 C CB   . HIS A 1 163 ? -14.67702 -29.69026 9.30028   1.000 18.59055 ? 163 HIS A CB   1 
ATOM   2480 C CG   . HIS A 1 163 ? -14.27516 -28.45312 8.59293   1.000 18.66471 ? 163 HIS A CG   1 
ATOM   2481 N ND1  . HIS A 1 163 ? -14.90106 -27.25870 8.84292   1.000 20.52481 ? 163 HIS A ND1  1 
ATOM   2482 C CD2  . HIS A 1 163 ? -13.44123 -28.24401 7.55269   1.000 20.26826 ? 163 HIS A CD2  1 
ATOM   2483 C CE1  . HIS A 1 163 ? -14.40982 -26.33680 8.03304   1.000 19.91173 ? 163 HIS A CE1  1 
ATOM   2484 N NE2  . HIS A 1 163 ? -13.51203 -26.90667 7.25361   1.000 19.83165 ? 163 HIS A NE2  1 
ATOM   2485 H H    . HIS A 1 163 ? -15.91679 -31.69504 10.04606  1.000 22.80723 ? 163 HIS A H    1 
ATOM   2486 H HA   . HIS A 1 163 ? -16.67420 -29.21963 9.44159   1.000 23.63561 ? 163 HIS A HA   1 
ATOM   2487 H HB2  . HIS A 1 163 ? -14.48293 -29.58025 10.24427  1.000 22.35894 ? 163 HIS A HB2  1 
ATOM   2488 H HB3  . HIS A 1 163 ? -14.16320 -30.42988 8.93993   1.000 22.35894 ? 163 HIS A HB3  1 
ATOM   2489 H HD2  . HIS A 1 163 ? -12.91975 -28.88240 7.12209   1.000 24.37221 ? 163 HIS A HD2  1 
ATOM   2490 H HE1  . HIS A 1 163 ? -14.65537 -25.43997 8.01594   1.000 23.94437 ? 163 HIS A HE1  1 
ATOM   2491 H HE2  . HIS A 1 163 ? -13.04533 -26.50448 6.65359   1.000 23.84828 ? 163 HIS A HE2  1 
ATOM   2492 N N    . HIS A 1 164 ? -17.04162 -29.07298 7.01865   1.000 20.92552 ? 164 HIS A N    1 
ATOM   2493 C CA   . HIS A 1 164 ? -17.39260 -29.08676 5.60381   1.000 19.72536 ? 164 HIS A CA   1 
ATOM   2494 C C    . HIS A 1 164 ? -16.83703 -27.93350 4.75067   1.000 19.88935 ? 164 HIS A C    1 
ATOM   2495 O O    . HIS A 1 164 ? -16.53525 -28.16296 3.58560   1.000 18.92810 ? 164 HIS A O    1 
ATOM   2496 C CB   . HIS A 1 164 ? -18.92059 -29.09216 5.42359   1.000 19.23814 ? 164 HIS A CB   1 
ATOM   2497 C CG   . HIS A 1 164 ? -19.59682 -30.35444 5.84807   1.000 19.40978 ? 164 HIS A CG   1 
ATOM   2498 N ND1  . HIS A 1 164 ? -20.21930 -31.19860 4.95205   1.000 18.63687 ? 164 HIS A ND1  1 
ATOM   2499 C CD2  . HIS A 1 164 ? -19.80899 -30.89216 7.07531   1.000 19.34110 ? 164 HIS A CD2  1 
ATOM   2500 C CE1  . HIS A 1 164 ? -20.76278 -32.21054 5.60300   1.000 18.15469 ? 164 HIS A CE1  1 
ATOM   2501 N NE2  . HIS A 1 164 ? -20.52311 -32.05144 6.89462   1.000 18.20078 ? 164 HIS A NE2  1 
ATOM   2502 H H    . HIS A 1 164 ? -17.24716 -28.34038 7.41946   1.000 25.16092 ? 164 HIS A H    1 
ATOM   2503 H HA   . HIS A 1 164 ? -17.00386 -29.90587 5.25907   1.000 23.72072 ? 164 HIS A HA   1 
ATOM   2504 H HB2  . HIS A 1 164 ? -19.29530 -28.36914 5.95059   1.000 23.13606 ? 164 HIS A HB2  1 
ATOM   2505 H HB3  . HIS A 1 164 ? -19.12028 -28.95602 4.48418   1.000 23.13606 ? 164 HIS A HB3  1 
ATOM   2506 H HD1  . HIS A 1 164 ? -20.24883 -31.08342 4.10031   1.000 22.41453 ? 164 HIS A HD1  1 
ATOM   2507 H HD2  . HIS A 1 164 ? -19.52390 -30.54111 7.88795   1.000 23.25961 ? 164 HIS A HD2  1 
ATOM   2508 H HE1  . HIS A 1 164 ? -21.23361 -32.91483 5.21933   1.000 21.83592 ? 164 HIS A HE1  1 
ATOM   2509 N N    . MET A 1 165 ? -16.74480 -26.70465 5.28246   1.000 19.83505 ? 165 MET A N    1 
ATOM   2510 C CA   . MET A 1 165 ? -16.43147 -25.60617 4.36850   1.000 21.29451 ? 165 MET A CA   1 
ATOM   2511 C C    . MET A 1 165 ? -15.92696 -24.36008 5.08701   1.000 21.24742 ? 165 MET A C    1 
ATOM   2512 O O    . MET A 1 165 ? -16.03270 -24.21697 6.30656   1.000 19.72246 ? 165 MET A O    1 
ATOM   2513 C CB   . MET A 1 165 ? -17.66462 -25.24690 3.52592   1.000 23.67001 ? 165 MET A CB   1 
ATOM   2514 C CG   . MET A 1 165 ? -18.82498 -24.74827 4.35529   1.000 23.14719 ? 165 MET A CG   1 
ATOM   2515 S SD   . MET A 1 165 ? -20.34384 -24.61271 3.38836   1.000 32.51485 ? 165 MET A SD   1 
ATOM   2516 C CE   . MET A 1 165 ? -19.78988 -23.59009 2.02676   1.000 30.44513 ? 165 MET A CE   1 
ATOM   2517 H H    . MET A 1 165 ? -16.85255 -26.50087 6.11099   1.000 23.85235 ? 165 MET A H    1 
ATOM   2518 H HA   . MET A 1 165 ? -15.70104 -25.92005 3.81276   1.000 25.60371 ? 165 MET A HA   1 
ATOM   2519 H HB2  . MET A 1 165 ? -17.42357 -24.54768 2.89833   1.000 28.45430 ? 165 MET A HB2  1 
ATOM   2520 H HB3  . MET A 1 165 ? -17.95817 -26.03693 3.04574   1.000 28.45430 ? 165 MET A HB3  1 
ATOM   2521 H HG2  . MET A 1 165 ? -18.98471 -25.36778 5.08440   1.000 27.82691 ? 165 MET A HG2  1 
ATOM   2522 H HG3  . MET A 1 165 ? -18.61081 -23.87004 4.70705   1.000 27.82691 ? 165 MET A HG3  1 
ATOM   2523 H HE1  . MET A 1 165 ? -19.46341 -22.74676 2.37763   1.000 36.58444 ? 165 MET A HE1  1 
ATOM   2524 H HE2  . MET A 1 165 ? -19.07771 -24.05022 1.55560   1.000 36.58444 ? 165 MET A HE2  1 
ATOM   2525 H HE3  . MET A 1 165 ? -20.53544 -23.43225 1.42666   1.000 36.58444 ? 165 MET A HE3  1 
ATOM   2526 N N    . GLU A 1 166 ? -15.39240 -23.44796 4.28205   1.000 22.46737 ? 166 GLU A N    1 
ATOM   2527 C CA   . GLU A 1 166 ? -14.90114 -22.15660 4.72364   1.000 22.29328 ? 166 GLU A CA   1 
ATOM   2528 C C    . GLU A 1 166 ? -15.66646 -21.06959 3.98246   1.000 24.74444 ? 166 GLU A C    1 
ATOM   2529 O O    . GLU A 1 166 ? -15.91550 -21.17541 2.77927   1.000 25.47344 ? 166 GLU A O    1 
ATOM   2530 C CB   . GLU A 1 166 ? -13.39915 -22.05730 4.47570   1.000 24.86154 ? 166 GLU A CB   1 
ATOM   2531 C CG   . GLU A 1 166 ? -12.81910 -20.70557 4.77324   1.000 24.67153 ? 166 GLU A CG   1 
ATOM   2532 C CD   . GLU A 1 166 ? -11.31687 -20.70164 4.67496   1.000 27.72833 ? 166 GLU A CD   1 
ATOM   2533 O OE1  . GLU A 1 166 ? -10.68804 -21.65521 5.19062   1.000 23.81999 ? 166 GLU A OE1  1 
ATOM   2534 O OE2  . GLU A 1 166 ? -10.77417 -19.75357 4.06405   1.000 29.93085 ? 166 GLU A OE2  1 
ATOM   2535 H H    . GLU A 1 166 ? -15.30088 -23.56392 3.43483   1.000 27.01113 ? 166 GLU A H    1 
ATOM   2536 H HA   . GLU A 1 166 ? -15.04909 -22.02207 5.67281   1.000 26.80223 ? 166 GLU A HA   1 
ATOM   2537 H HB2  . GLU A 1 166 ? -12.94744 -22.70317 5.04112   1.000 29.88413 ? 166 GLU A HB2  1 
ATOM   2538 H HB3  . GLU A 1 166 ? -13.22458 -22.25428 3.54209   1.000 29.88413 ? 166 GLU A HB3  1 
ATOM   2539 H HG2  . GLU A 1 166 ? -13.16616 -20.06225 4.13560   1.000 29.65613 ? 166 GLU A HG2  1 
ATOM   2540 H HG3  . GLU A 1 166 ? -13.06447 -20.44468 5.67470   1.000 29.65613 ? 166 GLU A HG3  1 
ATOM   2541 N N    . LEU A 1 167 ? -16.08737 -20.04510 4.72161   1.000 26.77049 ? 167 LEU A N    1 
ATOM   2542 C CA   . LEU A 1 167 ? -16.80184 -18.91378 4.15411   1.000 26.99979 ? 167 LEU A CA   1 
ATOM   2543 C C    . LEU A 1 167 ? -15.83112 -17.84890 3.67426   1.000 29.76195 ? 167 LEU A C    1 
ATOM   2544 O O    . LEU A 1 167 ? -14.69385 -17.77021 4.14689   1.000 29.79778 ? 167 LEU A O    1 
ATOM   2545 C CB   . LEU A 1 167 ? -17.73376 -18.30582 5.19374   1.000 27.06397 ? 167 LEU A CB   1 
ATOM   2546 C CG   . LEU A 1 167 ? -18.74005 -19.28199 5.79130   1.000 26.26600 ? 167 LEU A CG   1 
ATOM   2547 C CD1  . LEU A 1 167 ? -19.73428 -18.57367 6.69566   1.000 30.24423 ? 167 LEU A CD1  1 
ATOM   2548 C CD2  . LEU A 1 167 ? -19.44548 -20.01227 4.66355   1.000 28.97536 ? 167 LEU A CD2  1 
ATOM   2549 H H    . LEU A 1 167 ? -15.96704 -19.98424 5.57097   1.000 32.17488 ? 167 LEU A H    1 
ATOM   2550 H HA   . LEU A 1 167 ? -17.33049 -19.21827 3.39997   1.000 32.45004 ? 167 LEU A HA   1 
ATOM   2551 H HB2  . LEU A 1 167 ? -17.19659 -17.95606 5.92177   1.000 32.52706 ? 167 LEU A HB2  1 
ATOM   2552 H HB3  . LEU A 1 167 ? -18.23437 -17.58761 4.77605   1.000 32.52706 ? 167 LEU A HB3  1 
ATOM   2553 H HG   . LEU A 1 167 ? -18.27759 -19.92825 6.34751   1.000 31.56949 ? 167 LEU A HG   1 
ATOM   2554 H HD11 . LEU A 1 167 ? -20.33465 -19.23095 7.08094   1.000 36.34336 ? 167 LEU A HD11 1 
ATOM   2555 H HD12 . LEU A 1 167 ? -19.24969 -18.11533 7.39993   1.000 36.34336 ? 167 LEU A HD12 1 
ATOM   2556 H HD13 . LEU A 1 167 ? -20.23850 -17.93303 6.17009   1.000 36.34336 ? 167 LEU A HD13 1 
ATOM   2557 H HD21 . LEU A 1 167 ? -18.86590 -20.71568 4.33157   1.000 34.82072 ? 167 LEU A HD21 1 
ATOM   2558 H HD22 . LEU A 1 167 ? -20.26983 -20.39521 5.00224   1.000 34.82072 ? 167 LEU A HD22 1 
ATOM   2559 H HD23 . LEU A 1 167 ? -19.64113 -19.38187 3.95277   1.000 34.82072 ? 167 LEU A HD23 1 
ATOM   2560 N N    . PRO A 1 168 ? -16.26617 -16.96807 2.75736   1.000 31.72225 ? 168 PRO A N    1 
ATOM   2561 C CA   . PRO A 1 168 ? -15.36347 -15.93172 2.25703   1.000 32.64059 ? 168 PRO A CA   1 
ATOM   2562 C C    . PRO A 1 168 ? -14.73066 -15.07892 3.35436   1.000 31.07091 ? 168 PRO A C    1 
ATOM   2563 O O    . PRO A 1 168 ? -13.68395 -14.47927 3.11456   1.000 31.27761 ? 168 PRO A O    1 
ATOM   2564 C CB   . PRO A 1 168 ? -16.26316 -15.06637 1.35991   1.000 36.72392 ? 168 PRO A CB   1 
ATOM   2565 C CG   . PRO A 1 168 ? -17.39407 -15.93641 0.99177   1.000 33.47315 ? 168 PRO A CG   1 
ATOM   2566 C CD   . PRO A 1 168 ? -17.60596 -16.88012 2.14796   1.000 30.81931 ? 168 PRO A CD   1 
ATOM   2567 H HA   . PRO A 1 168 ? -14.66504 -16.35324 1.73223   1.000 39.21900 ? 168 PRO A HA   1 
ATOM   2568 H HB2  . PRO A 1 168 ? -16.57010 -14.28948 1.85298   1.000 44.11899 ? 168 PRO A HB2  1 
ATOM   2569 H HB3  . PRO A 1 168 ? -15.77100 -14.78631 0.57235   1.000 44.11899 ? 168 PRO A HB3  1 
ATOM   2570 H HG2  . PRO A 1 168 ? -18.18516 -15.39471 0.84468   1.000 40.21807 ? 168 PRO A HG2  1 
ATOM   2571 H HG3  . PRO A 1 168 ? -17.17478 -16.42914 0.18553   1.000 40.21807 ? 168 PRO A HG3  1 
ATOM   2572 H HD2  . PRO A 1 168 ? -18.24909 -16.51754 2.77711   1.000 37.03346 ? 168 PRO A HD2  1 
ATOM   2573 H HD3  . PRO A 1 168 ? -17.90157 -17.74945 1.83528   1.000 37.03346 ? 168 PRO A HD3  1 
ATOM   2574 N N    . THR A 1 169 ? -15.34749 -14.99550 4.53489   1.000 31.78502 ? 169 THR A N    1 
ATOM   2575 C CA   . THR A 1 169 ? -14.75130 -14.22083 5.61963   1.000 31.43025 ? 169 THR A CA   1 
ATOM   2576 C C    . THR A 1 169 ? -13.65808 -14.97802 6.36148   1.000 30.16276 ? 169 THR A C    1 
ATOM   2577 O O    . THR A 1 169 ? -13.11505 -14.45186 7.33703   1.000 30.61124 ? 169 THR A O    1 
ATOM   2578 C CB   . THR A 1 169 ? -15.82105 -13.77750 6.62157   1.000 31.88426 ? 169 THR A CB   1 
ATOM   2579 O OG1  . THR A 1 169 ? -16.58108 -14.90757 7.06384   1.000 32.15092 ? 169 THR A OG1  1 
ATOM   2580 C CG2  . THR A 1 169 ? -16.74114 -12.76688 5.97384   1.000 38.64056 ? 169 THR A CG2  1 
ATOM   2581 H H    . THR A 1 169 ? -16.09678 -15.37166 4.72635   1.000 38.19231 ? 169 THR A H    1 
ATOM   2582 H HA   . THR A 1 169 ? -14.35948 -13.42257 5.23213   1.000 37.76659 ? 169 THR A HA   1 
ATOM   2583 H HB   . THR A 1 169 ? -15.39808 -13.36810 7.39254   1.000 38.31141 ? 169 THR A HB   1 
ATOM   2584 H HG1  . THR A 1 169 ? -16.93929 -15.28807 6.40619   1.000 38.63139 ? 169 THR A HG1  1 
ATOM   2585 H HG21 . THR A 1 169 ? -17.40522 -12.46516 6.61327   1.000 46.41897 ? 169 THR A HG21 1 
ATOM   2586 H HG22 . THR A 1 169 ? -16.22991 -12.00204 5.66634   1.000 46.41897 ? 169 THR A HG22 1 
ATOM   2587 H HG23 . THR A 1 169 ? -17.19377 -13.16839 5.21568   1.000 46.41897 ? 169 THR A HG23 1 
ATOM   2588 N N    . GLY A 1 170 ? -13.31513 -16.18384 5.92481   1.000 28.48018 ? 170 GLY A N    1 
ATOM   2589 C CA   . GLY A 1 170 ? -12.29114 -16.94433 6.60717   1.000 29.25285 ? 170 GLY A CA   1 
ATOM   2590 C C    . GLY A 1 170 ? -12.75659 -17.73452 7.80714   1.000 32.21759 ? 170 GLY A C    1 
ATOM   2591 O O    . GLY A 1 170 ? -11.91970 -18.31819 8.50242   1.000 29.18150 ? 170 GLY A O    1 
ATOM   2592 H H    . GLY A 1 170 ? -13.66031 -16.57564 5.24148   1.000 34.22651 ? 170 GLY A H    1 
ATOM   2593 H HA2  . GLY A 1 170 ? -11.90190 -17.57081 5.97716   1.000 35.15371 ? 170 GLY A HA2  1 
ATOM   2594 H HA3  . GLY A 1 170 ? -11.60266 -16.33148 6.90934   1.000 35.15371 ? 170 GLY A HA3  1 
ATOM   2595 N N    . VAL A 1 171 ? -14.05684 -17.77516 8.07286   1.000 26.03690 ? 171 VAL A N    1 
ATOM   2596 C CA   . VAL A 1 171 ? -14.59143 -18.56699 9.15925   1.000 23.53680 ? 171 VAL A CA   1 
ATOM   2597 C C    . VAL A 1 171 ? -15.08959 -19.88606 8.58189   1.000 23.11761 ? 171 VAL A C    1 
ATOM   2598 O O    . VAL A 1 171 ? -15.10774 -20.09427 7.37072   1.000 23.13892 ? 171 VAL A O    1 
ATOM   2599 C CB   . VAL A 1 171 ? -15.70204 -17.82270 9.93266   1.000 23.62970 ? 171 VAL A CB   1 
ATOM   2600 C CG1  . VAL A 1 171 ? -15.16034 -16.52225 10.48361  1.000 25.76202 ? 171 VAL A CG1  1 
ATOM   2601 C CG2  . VAL A 1 171 ? -16.90776 -17.57469 9.04788   1.000 26.24709 ? 171 VAL A CG2  1 
ATOM   2602 H H    . VAL A 1 171 ? -14.65408 -17.34452 7.62850   1.000 31.29457 ? 171 VAL A H    1 
ATOM   2603 H HA   . VAL A 1 171 ? -13.88224 -18.75533 9.79366   1.000 28.29445 ? 171 VAL A HA   1 
ATOM   2604 H HB   . VAL A 1 171 ? -15.99596 -18.37434 10.67441  1.000 28.40593 ? 171 VAL A HB   1 
ATOM   2605 H HG11 . VAL A 1 171 ? -14.27764 -16.36566 10.11318  1.000 30.96471 ? 171 VAL A HG11 1 
ATOM   2606 H HG12 . VAL A 1 171 ? -15.75724 -15.79999 10.23272  1.000 30.96471 ? 171 VAL A HG12 1 
ATOM   2607 H HG13 . VAL A 1 171 ? -15.10687 -16.58661 11.44999  1.000 30.96471 ? 171 VAL A HG13 1 
ATOM   2608 H HG21 . VAL A 1 171 ? -17.53944 -17.01394 9.52478   1.000 31.54680 ? 171 VAL A HG21 1 
ATOM   2609 H HG22 . VAL A 1 171 ? -16.61768 -17.12980 8.23620   1.000 31.54680 ? 171 VAL A HG22 1 
ATOM   2610 H HG23 . VAL A 1 171 ? -17.31969 -18.42535 8.82970   1.000 31.54680 ? 171 VAL A HG23 1 
ATOM   2611 N N    . HIS A 1 172 ? -15.48975 -20.79836 9.45761   1.000 21.50867 ? 172 HIS A N    1 
ATOM   2612 C CA   . HIS A 1 172 ? -15.69455 -22.18837 9.08331   1.000 20.71991 ? 172 HIS A CA   1 
ATOM   2613 C C    . HIS A 1 172 ? -17.08013 -22.66853 9.46410   1.000 21.59543 ? 172 HIS A C    1 
ATOM   2614 O O    . HIS A 1 172 ? -17.67381 -22.21007 10.43934  1.000 21.86057 ? 172 HIS A O    1 
ATOM   2615 C CB   . HIS A 1 172 ? -14.60640 -23.04310 9.71594   1.000 21.45382 ? 172 HIS A CB   1 
ATOM   2616 C CG   . HIS A 1 172 ? -13.24717 -22.67341 9.22967   1.000 22.11110 ? 172 HIS A CG   1 
ATOM   2617 N ND1  . HIS A 1 172 ? -12.29493 -22.08353 10.02940  1.000 22.46615 ? 172 HIS A ND1  1 
ATOM   2618 C CD2  . HIS A 1 172 ? -12.71029 -22.73535 7.98924   1.000 22.44065 ? 172 HIS A CD2  1 
ATOM   2619 C CE1  . HIS A 1 172 ? -11.21506 -21.83311 9.31163   1.000 23.68871 ? 172 HIS A CE1  1 
ATOM   2620 N NE2  . HIS A 1 172 ? -11.44414 -22.21560 8.06816   1.000 23.16167 ? 172 HIS A NE2  1 
ATOM   2621 H H    . HIS A 1 172 ? -15.65116 -20.63304 10.28599  1.000 25.86069 ? 172 HIS A H    1 
ATOM   2622 H HA   . HIS A 1 172 ? -15.65751 -22.28964 8.11932   1.000 24.91418 ? 172 HIS A HA   1 
ATOM   2623 H HB2  . HIS A 1 172 ? -14.62679 -22.92290 10.67825  1.000 25.79488 ? 172 HIS A HB2  1 
ATOM   2624 H HB3  . HIS A 1 172 ? -14.76435 -23.97418 9.49449   1.000 25.79488 ? 172 HIS A HB3  1 
ATOM   2625 H HD2  . HIS A 1 172 ? -13.12324 -23.06844 7.22542   1.000 26.97907 ? 172 HIS A HD2  1 
ATOM   2626 H HE1  . HIS A 1 172 ? -10.42761 -21.45241 9.62770   1.000 28.47675 ? 172 HIS A HE1  1 
ATOM   2627 H HE2  . HIS A 1 172 ? -10.88927 -22.14934 7.41445   1.000 27.84429 ? 172 HIS A HE2  1 
ATOM   2628 N N    . ALA A 1 173 ? -17.58284 -23.60920 8.66427   1.000 20.56302 ? 173 ALA A N    1 
ATOM   2629 C CA   . ALA A 1 173 ? -18.95815 -24.06002 8.76660   1.000 20.40621 ? 173 ALA A CA   1 
ATOM   2630 C C    . ALA A 1 173 ? -19.01628 -25.56650 8.56484   1.000 19.25484 ? 173 ALA A C    1 
ATOM   2631 O O    . ALA A 1 173 ? -18.20185 -26.15850 7.85353   1.000 19.90701 ? 173 ALA A O    1 
ATOM   2632 C CB   . ALA A 1 173 ? -19.86510 -23.36148 7.74322   1.000 22.05878 ? 173 ALA A CB   1 
ATOM   2633 H H    . ALA A 1 173 ? -17.13461 -24.00449 8.04585   1.000 24.72591 ? 173 ALA A H    1 
ATOM   2634 H HA   . ALA A 1 173 ? -19.29349 -23.86078 9.65472   1.000 24.53774 ? 173 ALA A HA   1 
ATOM   2635 H HB1  . ALA A 1 173 ? -19.56220 -23.58408 6.84901   1.000 26.52082 ? 173 ALA A HB1  1 
ATOM   2636 H HB2  . ALA A 1 173 ? -20.77711 -23.66692 7.86913   1.000 26.52082 ? 173 ALA A HB2  1 
ATOM   2637 H HB3  . ALA A 1 173 ? -19.81557 -22.40247 7.88008   1.000 26.52082 ? 173 ALA A HB3  1 
ATOM   2638 N N    . GLY A 1 174 ? -20.01008 -26.17018 9.20079   1.000 18.85720 ? 174 GLY A N    1 
ATOM   2639 C CA   . GLY A 1 174 ? -20.09389 -27.61028 9.20381   1.000 17.88256 ? 174 GLY A CA   1 
ATOM   2640 C C    . GLY A 1 174 ? -21.41418 -28.07713 9.76242   1.000 19.19745 ? 174 GLY A C    1 
ATOM   2641 O O    . GLY A 1 174 ? -22.33879 -27.28532 9.98025   1.000 19.87155 ? 174 GLY A O    1 
ATOM   2642 H H    . GLY A 1 174 ? -20.63784 -25.76962 9.63098   1.000 22.67893 ? 174 GLY A H    1 
ATOM   2643 H HA2  . GLY A 1 174 ? -20.00464 -27.94417 8.29747   1.000 21.50936 ? 174 GLY A HA2  1 
ATOM   2644 H HA3  . GLY A 1 174 ? -19.37939 -27.97751 9.74744   1.000 21.50936 ? 174 GLY A HA3  1 
ATOM   2645 N N    . THR A 1 175 ? -21.49002 -29.38249 9.99972   1.000 19.02253 ? 175 THR A N    1 
ATOM   2646 C CA   . THR A 1 175 ? -22.71690 -30.04511 10.40416  1.000 19.52473 ? 175 THR A CA   1 
ATOM   2647 C C    . THR A 1 175 ? -22.56529 -30.73490 11.75839  1.000 20.62659 ? 175 THR A C    1 
ATOM   2648 O O    . THR A 1 175 ? -21.46260 -30.92889 12.27300  1.000 19.44263 ? 175 THR A O    1 
ATOM   2649 C CB   . THR A 1 175 ? -23.14178 -31.10086 9.36650   1.000 19.14751 ? 175 THR A CB   1 
ATOM   2650 O OG1  . THR A 1 175 ? -22.18461 -32.17373 9.35082   1.000 18.42128 ? 175 THR A OG1  1 
ATOM   2651 C CG2  . THR A 1 175 ? -23.24235 -30.49791 7.96828   1.000 20.01384 ? 175 THR A CG2  1 
ATOM   2652 H H    . THR A 1 175 ? -20.82119 -29.91858 9.92991   1.000 22.87732 ? 175 THR A H    1 
ATOM   2653 H HA   . THR A 1 175 ? -23.40073 -29.36208 10.48635  1.000 23.47997 ? 175 THR A HA   1 
ATOM   2654 H HB   . THR A 1 175 ? -24.01685 -31.44306 9.60745   1.000 23.02731 ? 175 THR A HB   1 
ATOM   2655 H HG1  . THR A 1 175 ? -22.22304 -32.60359 10.07148  1.000 22.15583 ? 175 THR A HG1  1 
ATOM   2656 H HG21 . THR A 1 175 ? -23.33996 -31.20289 7.30921   1.000 24.06690 ? 175 THR A HG21 1 
ATOM   2657 H HG22 . THR A 1 175 ? -24.01127 -29.90895 7.91548   1.000 24.06690 ? 175 THR A HG22 1 
ATOM   2658 H HG23 . THR A 1 175 ? -22.44141 -29.98863 7.76821   1.000 24.06690 ? 175 THR A HG23 1 
ATOM   2659 N N    . ASP A 1 176 ? -23.70569 -31.13618 12.31513  1.000 20.46432 ? 176 ASP A N    1 
ATOM   2660 C CA   . ASP A 1 176 ? -23.72306 -32.13433 13.36902  1.000 20.82024 ? 176 ASP A CA   1 
ATOM   2661 C C    . ASP A 1 176 ? -23.53216 -33.50687 12.72416  1.000 20.52027 ? 176 ASP A C    1 
ATOM   2662 O O    . ASP A 1 176 ? -23.39347 -33.63485 11.50704  1.000 20.19695 ? 176 ASP A O    1 
ATOM   2663 C CB   . ASP A 1 176 ? -24.99929 -31.99921 14.21347  1.000 21.56313 ? 176 ASP A CB   1 
ATOM   2664 C CG   . ASP A 1 176 ? -26.28856 -32.29041 13.43783  1.000 24.54944 ? 176 ASP A CG   1 
ATOM   2665 O OD1  . ASP A 1 176 ? -26.19831 -32.95782 12.38250  1.000 23.10617 ? 176 ASP A OD1  1 
ATOM   2666 O OD2  . ASP A 1 176 ? -27.38341 -31.87092 13.88265  1.000 22.31972 ? 176 ASP A OD2  1 
ATOM   2667 H H    . ASP A 1 176 ? -24.48350 -30.84177 12.09618  1.000 24.60748 ? 176 ASP A H    1 
ATOM   2668 H HA   . ASP A 1 176 ? -22.99300 -32.00168 13.99377  1.000 25.03457 ? 176 ASP A HA   1 
ATOM   2669 H HB2  . ASP A 1 176 ? -24.95174 -32.62506 14.95303  1.000 25.92604 ? 176 ASP A HB2  1 
ATOM   2670 H HB3  . ASP A 1 176 ? -25.05586 -31.09132 14.55027  1.000 25.92604 ? 176 ASP A HB3  1 
ATOM   2671 N N    . LEU A 1 177 ? -23.48504 -34.55330 13.53883  1.000 20.67750 ? 177 LEU A N    1 
ATOM   2672 C CA   . LEU A 1 177 ? -23.16385 -35.87023 13.00582  1.000 21.32446 ? 177 LEU A CA   1 
ATOM   2673 C C    . LEU A 1 177 ? -24.36596 -36.54713 12.35989  1.000 22.18594 ? 177 LEU A C    1 
ATOM   2674 O O    . LEU A 1 177 ? -24.23467 -37.67477 11.86976  1.000 22.72362 ? 177 LEU A O    1 
ATOM   2675 C CB   . LEU A 1 177 ? -22.57307 -36.74312 14.11163  1.000 21.48035 ? 177 LEU A CB   1 
ATOM   2676 C CG   . LEU A 1 177 ? -21.04618 -36.69415 14.21452  1.000 24.44168 ? 177 LEU A CG   1 
ATOM   2677 C CD1  . LEU A 1 177 ? -20.43109 -37.32141 12.99849  1.000 23.12801 ? 177 LEU A CD1  1 
ATOM   2678 C CD2  . LEU A 1 177 ? -20.54900 -35.26776 14.35499  1.000 22.59454 ? 177 LEU A CD2  1 
ATOM   2679 H H    . LEU A 1 177 ? -23.63201 -34.52693 14.38577  1.000 24.86330 ? 177 LEU A H    1 
ATOM   2680 H HA   . LEU A 1 177 ? -22.48437 -35.78493 12.31885  1.000 25.63965 ? 177 LEU A HA   1 
ATOM   2681 H HB2  . LEU A 1 177 ? -22.93394 -36.44847 14.96243  1.000 25.82670 ? 177 LEU A HB2  1 
ATOM   2682 H HB3  . LEU A 1 177 ? -22.82638 -37.66452 13.94505  1.000 25.82670 ? 177 LEU A HB3  1 
ATOM   2683 H HG   . LEU A 1 177 ? -20.77499 -37.18676 15.00491  1.000 29.38030 ? 177 LEU A HG   1 
ATOM   2684 H HD11 . LEU A 1 177 ? -19.48751 -37.09824 12.97107  1.000 27.80390 ? 177 LEU A HD11 1 
ATOM   2685 H HD12 . LEU A 1 177 ? -20.54207 -38.28370 13.04914  1.000 27.80390 ? 177 LEU A HD12 1 
ATOM   2686 H HD13 . LEU A 1 177 ? -20.87525 -36.97840 12.20731  1.000 27.80390 ? 177 LEU A HD13 1 
ATOM   2687 H HD21 . LEU A 1 177 ? -19.59554 -35.28173 14.53280  1.000 27.16374 ? 177 LEU A HD21 1 
ATOM   2688 H HD22 . LEU A 1 177 ? -20.72459 -34.78940 13.52962  1.000 27.16374 ? 177 LEU A HD22 1 
ATOM   2689 H HD23 . LEU A 1 177 ? -21.01639 -34.84138 15.09028  1.000 27.16374 ? 177 LEU A HD23 1 
ATOM   2690 N N    . GLU A 1 178 ? -25.52135 -35.88912 12.34861  1.000 22.55386 ? 178 GLU A N    1 
ATOM   2691 C CA   . GLU A 1 178 ? -26.62051 -36.28165 11.48032  1.000 23.60368 ? 178 GLU A CA   1 
ATOM   2692 C C    . GLU A 1 178 ? -26.58558 -35.55635 10.13240  1.000 22.13164 ? 178 GLU A C    1 
ATOM   2693 O O    . GLU A 1 178 ? -27.46677 -35.79315 9.30648   1.000 22.94057 ? 178 GLU A O    1 
ATOM   2694 C CB   . GLU A 1 178 ? -27.96158 -36.03311 12.17123  1.000 24.70431 ? 178 GLU A CB   1 
ATOM   2695 C CG   . GLU A 1 178 ? -28.08756 -36.80025 13.46572  1.000 25.35185 ? 178 GLU A CG   1 
ATOM   2696 C CD   . GLU A 1 178 ? -29.46665 -36.70494 14.06935  1.000 36.36583 ? 178 GLU A CD   1 
ATOM   2697 O OE1  . GLU A 1 178 ? -30.12502 -35.65723 13.88003  1.000 33.20543 ? 178 GLU A OE1  1 
ATOM   2698 O OE2  . GLU A 1 178 ? -29.89130 -37.68433 14.71980  1.000 37.21186 ? 178 GLU A OE2  1 
ATOM   2699 H H    . GLU A 1 178 ? -25.69228 -35.20503 12.84096  1.000 27.11492 ? 178 GLU A H    1 
ATOM   2700 H HA   . GLU A 1 178 ? -26.55899 -37.23452 11.30956  1.000 28.37471 ? 178 GLU A HA   1 
ATOM   2701 H HB2  . GLU A 1 178 ? -28.04606 -35.08752 12.37030  1.000 29.69546 ? 178 GLU A HB2  1 
ATOM   2702 H HB3  . GLU A 1 178 ? -28.67935 -36.31354 11.58210  1.000 29.69546 ? 178 GLU A HB3  1 
ATOM   2703 H HG2  . GLU A 1 178 ? -27.89778 -37.73659 13.29791  1.000 30.47251 ? 178 GLU A HG2  1 
ATOM   2704 H HG3  . GLU A 1 178 ? -27.45399 -36.44319 14.10759  1.000 30.47251 ? 178 GLU A HG3  1 
ATOM   2705 N N    . GLY A 1 179 ? -25.60160 -34.69727 9.88829   1.000 21.13213 ? 179 GLY A N    1 
ATOM   2706 C CA   . GLY A 1 179 ? -25.47108 -34.06908 8.58468   1.000 20.58712 ? 179 GLY A CA   1 
ATOM   2707 C C    . GLY A 1 179 ? -26.20769 -32.76172 8.39341   1.000 20.31493 ? 179 GLY A C    1 
ATOM   2708 O O    . GLY A 1 179 ? -26.21520 -32.22698 7.27599   1.000 20.43251 ? 179 GLY A O    1 
ATOM   2709 H H    . GLY A 1 179 ? -25.00201 -34.46497 10.45937  1.000 25.40885 ? 179 GLY A H    1 
ATOM   2710 H HA2  . GLY A 1 179 ? -24.53031 -33.89789 8.42175   1.000 24.75483 ? 179 GLY A HA2  1 
ATOM   2711 H HA3  . GLY A 1 179 ? -25.80027 -34.68772 7.91399   1.000 24.75483 ? 179 GLY A HA3  1 
ATOM   2712 N N    . ASN A 1 180 ? -26.81327 -32.21883 9.45042   1.000 20.87023 ? 180 ASN A N    1 
ATOM   2713 C CA   . ASN A 1 180 ? -27.52778 -30.95470 9.38452   1.000 22.77567 ? 180 ASN A CA   1 
ATOM   2714 C C    . ASN A 1 180 ? -26.56652 -29.82133 9.70543   1.000 21.29645 ? 180 ASN A C    1 
ATOM   2715 O O    . ASN A 1 180 ? -25.96720 -29.79518 10.78490  1.000 21.57059 ? 180 ASN A O    1 
ATOM   2716 C CB   . ASN A 1 180 ? -28.69882 -30.95663 10.36299  1.000 24.46419 ? 180 ASN A CB   1 
ATOM   2717 C CG   . ASN A 1 180 ? -29.75220 -31.98259 10.00316  1.000 28.08327 ? 180 ASN A CG   1 
ATOM   2718 O OD1  . ASN A 1 180 ? -30.31100 -31.95796 8.90728   1.000 28.83549 ? 180 ASN A OD1  1 
ATOM   2719 N ND2  . ASN A 1 180 ? -30.00246 -32.91654 10.91080  1.000 30.05412 ? 180 ASN A ND2  1 
ATOM   2720 H H    . ASN A 1 180 ? -26.82172 -32.57580 10.23279  1.000 25.09457 ? 180 ASN A H    1 
ATOM   2721 H HA   . ASN A 1 180 ? -27.87397 -30.82084 8.48834   1.000 27.38109 ? 180 ASN A HA   1 
ATOM   2722 H HB2  . ASN A 1 180 ? -28.36917 -31.16252 11.25172  1.000 29.40732 ? 180 ASN A HB2  1 
ATOM   2723 H HB3  . ASN A 1 180 ? -29.11707 -30.08145 10.35877  1.000 29.40732 ? 180 ASN A HB3  1 
ATOM   2724 H HD21 . ASN A 1 180 ? -30.59259 -33.52199 10.75337  1.000 36.11524 ? 180 ASN A HD21 1 
ATOM   2725 H HD22 . ASN A 1 180 ? -29.57462 -32.91675 11.65682  1.000 36.11524 ? 180 ASN A HD22 1 
ATOM   2726 N N    . PHE A 1 181 ? -26.41808 -28.88457 8.77138   1.000 20.74942 ? 181 PHE A N    1 
ATOM   2727 C CA   . PHE A 1 181 ? -25.54845 -27.74537 9.00440   1.000 21.63033 ? 181 PHE A CA   1 
ATOM   2728 C C    . PHE A 1 181 ? -25.96747 -26.97584 10.25119  1.000 23.79881 ? 181 PHE A C    1 
ATOM   2729 O O    . PHE A 1 181 ? -27.15284 -26.87375 10.57529  1.000 23.77989 ? 181 PHE A O    1 
ATOM   2730 C CB   . PHE A 1 181 ? -25.56466 -26.80820 7.79436   1.000 22.50148 ? 181 PHE A CB   1 
ATOM   2731 C CG   . PHE A 1 181 ? -24.44100 -27.05057 6.84701   1.000 22.52618 ? 181 PHE A CG   1 
ATOM   2732 C CD1  . PHE A 1 181 ? -24.58464 -27.94565 5.80560   1.000 21.37765 ? 181 PHE A CD1  1 
ATOM   2733 C CD2  . PHE A 1 181 ? -23.22921 -26.40644 7.01598   1.000 22.36520 ? 181 PHE A CD2  1 
ATOM   2734 C CE1  . PHE A 1 181 ? -23.54340 -28.18878 4.93824   1.000 22.44341 ? 181 PHE A CE1  1 
ATOM   2735 C CE2  . PHE A 1 181 ? -22.18269 -26.64117 6.15394   1.000 20.81489 ? 181 PHE A CE2  1 
ATOM   2736 C CZ   . PHE A 1 181 ? -22.34113 -27.53344 5.10759   1.000 21.60871 ? 181 PHE A CZ   1 
ATOM   2737 H H    . PHE A 1 181 ? -26.80682 -28.88847 8.00426   1.000 24.94960 ? 181 PHE A H    1 
ATOM   2738 H HA   . PHE A 1 181 ? -24.64379 -28.06915 9.13729   1.000 26.00669 ? 181 PHE A HA   1 
ATOM   2739 H HB2  . PHE A 1 181 ? -26.39548 -26.93537 7.31015   1.000 27.05206 ? 181 PHE A HB2  1 
ATOM   2740 H HB3  . PHE A 1 181 ? -25.49930 -25.89202 8.10620   1.000 27.05206 ? 181 PHE A HB3  1 
ATOM   2741 H HD1  . PHE A 1 181 ? -25.39365 -28.38921 5.68872   1.000 25.70347 ? 181 PHE A HD1  1 
ATOM   2742 H HD2  . PHE A 1 181 ? -23.12032 -25.80824 7.71968   1.000 26.88852 ? 181 PHE A HD2  1 
ATOM   2743 H HE1  . PHE A 1 181 ? -23.65023 -28.79343 4.23975   1.000 26.98238 ? 181 PHE A HE1  1 
ATOM   2744 H HE2  . PHE A 1 181 ? -21.37180 -26.20189 6.27388   1.000 25.02815 ? 181 PHE A HE2  1 
ATOM   2745 H HZ   . PHE A 1 181 ? -21.63810 -27.69097 4.51951   1.000 25.98074 ? 181 PHE A HZ   1 
ATOM   2746 N N    . TYR A 1 182 ? -24.97797 -26.45990 10.96175  1.000 23.01931 ? 182 TYR A N    1 
ATOM   2747 C CA   . TYR A 1 182 ? -25.20169 -25.32731 11.84764  1.000 23.23893 ? 182 TYR A CA   1 
ATOM   2748 C C    . TYR A 1 182 ? -25.29991 -24.07574 10.98332  1.000 22.78440 ? 182 TYR A C    1 
ATOM   2749 O O    . TYR A 1 182 ? -24.46314 -23.85883 10.09792  1.000 23.29937 ? 182 TYR A O    1 
ATOM   2750 C CB   . TYR A 1 182 ? -24.06902 -25.20420 12.86118  1.000 23.59872 ? 182 TYR A CB   1 
ATOM   2751 C CG   . TYR A 1 182 ? -23.98119 -26.35563 13.83681  1.000 22.27336 ? 182 TYR A CG   1 
ATOM   2752 C CD1  . TYR A 1 182 ? -24.74986 -26.36645 14.99370  1.000 21.92487 ? 182 TYR A CD1  1 
ATOM   2753 C CD2  . TYR A 1 182 ? -23.11695 -27.41613 13.61506  1.000 21.60050 ? 182 TYR A CD2  1 
ATOM   2754 C CE1  . TYR A 1 182 ? -24.66931 -27.40393 15.88822  1.000 24.11181 ? 182 TYR A CE1  1 
ATOM   2755 C CE2  . TYR A 1 182 ? -23.03049 -28.46183 14.50979  1.000 21.39981 ? 182 TYR A CE2  1 
ATOM   2756 C CZ   . TYR A 1 182 ? -23.81082 -28.44350 15.64391  1.000 21.37436 ? 182 TYR A CZ   1 
ATOM   2757 O OH   . TYR A 1 182 ? -23.74496 -29.46548 16.55347  1.000 22.38642 ? 182 TYR A OH   1 
ATOM   2758 H H    . TYR A 1 182 ? -24.16722 -26.74649 10.94970  1.000 27.67347 ? 182 TYR A H    1 
ATOM   2759 H HA   . TYR A 1 182 ? -26.02089 -25.43844 12.35505  1.000 27.93701 ? 182 TYR A HA   1 
ATOM   2760 H HB2  . TYR A 1 182 ? -23.22713 -25.16051 12.38138  1.000 28.36876 ? 182 TYR A HB2  1 
ATOM   2761 H HB3  . TYR A 1 182 ? -24.20024 -24.39235 13.37557  1.000 28.36876 ? 182 TYR A HB3  1 
ATOM   2762 H HD1  . TYR A 1 182 ? -25.32863 -25.65890 15.16486  1.000 26.36013 ? 182 TYR A HD1  1 
ATOM   2763 H HD2  . TYR A 1 182 ? -22.58701 -27.42263 12.85084  1.000 25.97089 ? 182 TYR A HD2  1 
ATOM   2764 H HE1  . TYR A 1 182 ? -25.19437 -27.40148 16.65583  1.000 28.98446 ? 182 TYR A HE1  1 
ATOM   2765 H HE2  . TYR A 1 182 ? -22.45148 -29.17159 14.34891  1.000 25.73006 ? 182 TYR A HE2  1 
ATOM   2766 H HH   . TYR A 1 182 ? -24.25387 -29.30577 17.20240  1.000 26.91400 ? 182 TYR A HH   1 
ATOM   2767 N N    . GLY A 1 183 ? -26.33001 -23.27279 11.20799  1.000 24.27997 ? 183 GLY A N    1 
ATOM   2768 C CA   . GLY A 1 183 ? -26.50827 -22.06007 10.44345  1.000 25.12079 ? 183 GLY A CA   1 
ATOM   2769 C C    . GLY A 1 183 ? -27.20618 -22.29450 9.11880   1.000 26.16612 ? 183 GLY A C    1 
ATOM   2770 O O    . GLY A 1 183 ? -27.69438 -23.39044 8.82891   1.000 25.36695 ? 183 GLY A O    1 
ATOM   2771 H H    . GLY A 1 183 ? -26.93788 -23.41295 11.79997  1.000 29.18625 ? 183 GLY A H    1 
ATOM   2772 H HA2  . GLY A 1 183 ? -27.03906 -21.43299 10.95914  1.000 30.19524 ? 183 GLY A HA2  1 
ATOM   2773 H HA3  . GLY A 1 183 ? -25.64041 -21.66596 10.26347  1.000 30.19524 ? 183 GLY A HA3  1 
ATOM   2774 N N    . PRO A 1 184 ? -27.25110 -21.25643 8.28046   1.000 26.25778 ? 184 PRO A N    1 
ATOM   2775 C CA   . PRO A 1 184 ? -28.03916 -21.32065 7.03711   1.000 27.09536 ? 184 PRO A CA   1 
ATOM   2776 C C    . PRO A 1 184 ? -27.27816 -21.86279 5.83669   1.000 31.06270 ? 184 PRO A C    1 
ATOM   2777 O O    . PRO A 1 184 ? -27.69476 -21.70909 4.68486   1.000 32.37517 ? 184 PRO A O    1 
ATOM   2778 C CB   . PRO A 1 184 ? -28.43361 -19.85362 6.81967   1.000 32.27946 ? 184 PRO A CB   1 
ATOM   2779 C CG   . PRO A 1 184 ? -27.28803 -19.08729 7.41446   1.000 30.88132 ? 184 PRO A CG   1 
ATOM   2780 C CD   . PRO A 1 184 ? -26.76072 -19.89723 8.56689   1.000 30.64639 ? 184 PRO A CD   1 
ATOM   2781 H HA   . PRO A 1 184 ? -28.82179 -21.87585 7.17897   1.000 32.56473 ? 184 PRO A HA   1 
ATOM   2782 H HB2  . PRO A 1 184 ? -28.52715 -19.66809 5.87218   1.000 38.78564 ? 184 PRO A HB2  1 
ATOM   2783 H HB3  . PRO A 1 184 ? -29.26482 -19.65781 7.27971   1.000 38.78564 ? 184 PRO A HB3  1 
ATOM   2784 H HG2  . PRO A 1 184 ? -26.59895 -18.96614 6.74259   1.000 37.10788 ? 184 PRO A HG2  1 
ATOM   2785 H HG3  . PRO A 1 184 ? -27.60480 -18.22436 7.72415   1.000 37.10788 ? 184 PRO A HG3  1 
ATOM   2786 H HD2  . PRO A 1 184 ? -25.79114 -19.87749 8.58732   1.000 36.82595 ? 184 PRO A HD2  1 
ATOM   2787 H HD3  . PRO A 1 184 ? -27.11698 -19.57221 9.40852   1.000 36.82595 ? 184 PRO A HD3  1 
ATOM   2788 N N    . PHE A 1 185 ? -26.17658 -22.54602 6.10493   1.000 27.80031 ? 185 PHE A N    1 
ATOM   2789 C CA   . PHE A 1 185 ? -25.22362 -22.87809 5.06103   1.000 26.24519 ? 185 PHE A CA   1 
ATOM   2790 C C    . PHE A 1 185 ? -25.60740 -24.14699 4.32265   1.000 24.98772 ? 185 PHE A C    1 
ATOM   2791 O O    . PHE A 1 185 ? -26.32464 -25.01198 4.83442   1.000 24.97336 ? 185 PHE A O    1 
ATOM   2792 C CB   . PHE A 1 185 ? -23.84248 -22.99050 5.69760   1.000 25.71167 ? 185 PHE A CB   1 
ATOM   2793 C CG   . PHE A 1 185 ? -23.50593 -21.81065 6.55621   1.000 25.22939 ? 185 PHE A CG   1 
ATOM   2794 C CD1  . PHE A 1 185 ? -23.45194 -20.54342 5.99864   1.000 27.15249 ? 185 PHE A CD1  1 
ATOM   2795 C CD2  . PHE A 1 185 ? -23.28548 -21.94964 7.91737   1.000 25.57487 ? 185 PHE A CD2  1 
ATOM   2796 C CE1  . PHE A 1 185 ? -23.16304 -19.43647 6.77511   1.000 27.66832 ? 185 PHE A CE1  1 
ATOM   2797 C CE2  . PHE A 1 185 ? -22.99931 -20.84169 8.70153   1.000 25.66967 ? 185 PHE A CE2  1 
ATOM   2798 C CZ   . PHE A 1 185 ? -22.93017 -19.58719 8.12641   1.000 25.03309 ? 185 PHE A CZ   1 
ATOM   2799 H H    . PHE A 1 185 ? -25.95735 -22.82980 6.88660   1.000 33.41066 ? 185 PHE A H    1 
ATOM   2800 H HA   . PHE A 1 185 ? -25.20323 -22.18640 4.38129   1.000 31.54451 ? 185 PHE A HA   1 
ATOM   2801 H HB2  . PHE A 1 185 ? -23.81419 -23.78492 6.25348   1.000 30.90430 ? 185 PHE A HB2  1 
ATOM   2802 H HB3  . PHE A 1 185 ? -23.17516 -23.05235 4.99634   1.000 30.90430 ? 185 PHE A HB3  1 
ATOM   2803 H HD1  . PHE A 1 185 ? -23.61234 -20.43581 5.08892   1.000 32.63327 ? 185 PHE A HD1  1 
ATOM   2804 H HD2  . PHE A 1 185 ? -23.32974 -22.79238 8.30817   1.000 30.74013 ? 185 PHE A HD2  1 
ATOM   2805 H HE1  . PHE A 1 185 ? -23.12579 -18.59206 6.38719   1.000 33.25227 ? 185 PHE A HE1  1 
ATOM   2806 H HE2  . PHE A 1 185 ? -22.85397 -20.94327 9.61447   1.000 30.85390 ? 185 PHE A HE2  1 
ATOM   2807 H HZ   . PHE A 1 185 ? -22.72695 -18.84561 8.64953   1.000 30.09000 ? 185 PHE A HZ   1 
ATOM   2808 N N    . VAL A 1 186 ? -25.15443 -24.22149 3.07639   1.000 25.02406 ? 186 VAL A N    1 
ATOM   2809 C CA   . VAL A 1 186 ? -25.33371 -25.38090 2.22394   1.000 24.09631 ? 186 VAL A CA   1 
ATOM   2810 C C    . VAL A 1 186 ? -23.96079 -25.76036 1.70141   1.000 23.56471 ? 186 VAL A C    1 
ATOM   2811 O O    . VAL A 1 186 ? -23.07023 -24.91260 1.57029   1.000 24.58952 ? 186 VAL A O    1 
ATOM   2812 C CB   . VAL A 1 186 ? -26.30950 -25.11171 1.06371   1.000 27.82929 ? 186 VAL A CB   1 
ATOM   2813 C CG1  . VAL A 1 186 ? -27.68072 -24.80923 1.62601   1.000 31.26157 ? 186 VAL A CG1  1 
ATOM   2814 C CG2  . VAL A 1 186 ? -25.82454 -23.96280 0.21607   1.000 27.08836 ? 186 VAL A CG2  1 
ATOM   2815 H H    . VAL A 1 186 ? -24.72324 -23.58543 2.69026   1.000 30.07917 ? 186 VAL A H    1 
ATOM   2816 H HA   . VAL A 1 186 ? -25.70021 -26.11855 2.73625   1.000 28.96586 ? 186 VAL A HA   1 
ATOM   2817 H HB   . VAL A 1 186 ? -26.36257 -25.89656 0.49618   1.000 33.44544 ? 186 VAL A HB   1 
ATOM   2818 H HG11 . VAL A 1 186 ? -28.33466 -24.86705 0.91193   1.000 37.56418 ? 186 VAL A HG11 1 
ATOM   2819 H HG12 . VAL A 1 186 ? -27.88823 -25.45674 2.31780   1.000 37.56418 ? 186 VAL A HG12 1 
ATOM   2820 H HG13 . VAL A 1 186 ? -27.67812 -23.91444 2.00051   1.000 37.56418 ? 186 VAL A HG13 1 
ATOM   2821 H HG21 . VAL A 1 186 ? -25.15661 -24.28974 -0.40672  1.000 32.55633 ? 186 VAL A HG21 1 
ATOM   2822 H HG22 . VAL A 1 186 ? -26.57628 -23.59009 -0.27063  1.000 32.55633 ? 186 VAL A HG22 1 
ATOM   2823 H HG23 . VAL A 1 186 ? -25.43603 -23.28669 0.79299   1.000 32.55633 ? 186 VAL A HG23 1 
ATOM   2824 N N    . ASP A 1 187 ? -23.78751 -27.04524 1.42560   1.000 22.76992 ? 187 ASP A N    1 
ATOM   2825 C CA   . ASP A 1 187 ? -22.49680 -27.53194 0.95913   1.000 22.61713 ? 187 ASP A CA   1 
ATOM   2826 C C    . ASP A 1 187 ? -22.41130 -27.39316 -0.56687  1.000 24.35539 ? 187 ASP A C    1 
ATOM   2827 O O    . ASP A 1 187 ? -22.47848 -28.35279 -1.32380  1.000 25.16700 ? 187 ASP A O    1 
ATOM   2828 C CB   . ASP A 1 187 ? -22.25083 -28.96430 1.42527   1.000 21.70944 ? 187 ASP A CB   1 
ATOM   2829 C CG   . ASP A 1 187 ? -23.42289 -29.90351 1.19364   1.000 23.47360 ? 187 ASP A CG   1 
ATOM   2830 O OD1  . ASP A 1 187 ? -24.57908 -29.46951 0.99116   1.000 25.24845 ? 187 ASP A OD1  1 
ATOM   2831 O OD2  . ASP A 1 187 ? -23.15620 -31.11841 1.25088   1.000 21.10683 ? 187 ASP A OD2  1 
ATOM   2832 H H    . ASP A 1 187 ? -24.39540 -27.64905 1.49968   1.000 27.37419 ? 187 ASP A H    1 
ATOM   2833 H HA   . ASP A 1 187 ? -21.80182 -26.97725 1.34670   1.000 27.19085 ? 187 ASP A HA   1 
ATOM   2834 H HB2  . ASP A 1 187 ? -21.48838 -29.32126 0.94345   1.000 26.10162 ? 187 ASP A HB2  1 
ATOM   2835 H HB3  . ASP A 1 187 ? -22.06624 -28.95380 2.37749   1.000 26.10162 ? 187 ASP A HB3  1 
ATOM   2836 N N    . ARG A 1 188 ? -22.22422 -26.14683 -0.99186  1.000 26.29547 ? 188 ARG A N    1 
ATOM   2837 C CA   . ARG A 1 188 ? -21.88191 -25.86857 -2.38298  1.000 26.72728 ? 188 ARG A CA   1 
ATOM   2838 C C    . ARG A 1 188 ? -21.04351 -24.59925 -2.40746  1.000 28.80339 ? 188 ARG A C    1 
ATOM   2839 O O    . ARG A 1 188 ? -21.14516 -23.75212 -1.51602  1.000 27.03697 ? 188 ARG A O    1 
ATOM   2840 C CB   . ARG A 1 188 ? -23.13686 -25.77236 -3.26535  1.000 32.08149 ? 188 ARG A CB   1 
ATOM   2841 C CG   . ARG A 1 188 ? -23.98059 -24.52732 -3.08431  1.000 38.52714 ? 188 ARG A CG   1 
ATOM   2842 C CD   . ARG A 1 188 ? -25.45821 -24.71768 -3.52290  1.000 51.33207 ? 188 ARG A CD   1 
ATOM   2843 N NE   . ARG A 1 188 ? -25.99816 -26.05758 -3.29584  1.000 55.16847 ? 188 ARG A NE   1 
ATOM   2844 C CZ   . ARG A 1 188 ? -26.28423 -26.93913 -4.25146  1.000 57.43637 ? 188 ARG A CZ   1 
ATOM   2845 N NH1  . ARG A 1 188 ? -26.12924 -26.65090 -5.53446  1.000 50.37629 ? 188 ARG A NH1  1 
ATOM   2846 N NH2  . ARG A 1 188 ? -26.73823 -28.14131 -3.90858  1.000 63.00696 ? 188 ARG A NH2  1 
ATOM   2847 H H    . ARG A 1 188 ? -22.28961 -25.44756 -0.49553  1.000 31.60485 ? 188 ARG A H    1 
ATOM   2848 H HA   . ARG A 1 188 ? -21.34198 -26.57926 -2.76284  1.000 32.12302 ? 188 ARG A HA   1 
ATOM   2849 H HB2  . ARG A 1 188 ? -22.85732 -25.79678 -4.19387  1.000 38.54807 ? 188 ARG A HB2  1 
ATOM   2850 H HB3  . ARG A 1 188 ? -23.70436 -26.53427 -3.06958  1.000 38.54807 ? 188 ARG A HB3  1 
ATOM   2851 H HG2  . ARG A 1 188 ? -23.97845 -24.27965 -2.14647  1.000 46.28286 ? 188 ARG A HG2  1 
ATOM   2852 H HG3  . ARG A 1 188 ? -23.60221 -23.81079 -3.61753  1.000 46.28286 ? 188 ARG A HG3  1 
ATOM   2853 H HD2  . ARG A 1 188 ? -26.01013 -24.09357 -3.02613  1.000 61.64877 ? 188 ARG A HD2  1 
ATOM   2854 H HD3  . ARG A 1 188 ? -25.52375 -24.53481 -4.47325  1.000 61.64877 ? 188 ARG A HD3  1 
ATOM   2855 H HE   . ARG A 1 188 ? -26.14208 -26.29447 -2.48173  1.000 66.25246 ? 188 ARG A HE   1 
ATOM   2856 H HH11 . ARG A 1 188 ? -25.83674 -25.87693 -5.76902  1.000 60.50183 ? 188 ARG A HH11 1 
ATOM   2857 H HH12 . ARG A 1 188 ? -26.32108 -27.23766 -6.13322  1.000 60.50183 ? 188 ARG A HH12 1 
ATOM   2858 H HH21 . ARG A 1 188 ? -26.84349 -28.34057 -3.07863  1.000 75.65865 ? 188 ARG A HH21 1 
ATOM   2859 H HH22 . ARG A 1 188 ? -26.92653 -28.71940 -4.51682  1.000 75.65865 ? 188 ARG A HH22 1 
ATOM   2860 N N    . GLN A 1 189 ? -20.18034 -24.49539 -3.41641  1.000 31.67869 ? 189 GLN A N    1 
ATOM   2861 C CA   . GLN A 1 189 ? -19.20992 -23.40491 -3.47372  1.000 33.09634 ? 189 GLN A CA   1 
ATOM   2862 C C    . GLN A 1 189 ? -19.84339 -22.18516 -4.13648  1.000 35.15956 ? 189 GLN A C    1 
ATOM   2863 O O    . GLN A 1 189 ? -19.54769 -21.80338 -5.27026  1.000 37.70680 ? 189 GLN A O    1 
ATOM   2864 C CB   . GLN A 1 189 ? -17.94896 -23.84975 -4.19611  1.000 33.80135 ? 189 GLN A CB   1 
ATOM   2865 C CG   . GLN A 1 189 ? -16.84639 -24.16738 -3.23109  1.000 33.70334 ? 189 GLN A CG   1 
ATOM   2866 C CD   . GLN A 1 189 ? -15.74795 -24.98942 -3.84998  1.000 32.27912 ? 189 GLN A CD   1 
ATOM   2867 O OE1  . GLN A 1 189 ? -15.05648 -25.72344 -3.15024  1.000 31.66926 ? 189 GLN A OE1  1 
ATOM   2868 N NE2  . GLN A 1 189 ? -15.57961 -24.87921 -5.16263  1.000 40.06548 ? 189 GLN A NE2  1 
ATOM   2869 H H    . GLN A 1 189 ? -20.13729 -25.04298 -4.07814  1.000 38.06472 ? 189 GLN A H    1 
ATOM   2870 H HA   . GLN A 1 189 ? -18.96666 -23.16020 -2.56716  1.000 39.76590 ? 189 GLN A HA   1 
ATOM   2871 H HB2  . GLN A 1 189 ? -18.14076 -24.64693 -4.71439  1.000 40.61191 ? 189 GLN A HB2  1 
ATOM   2872 H HB3  . GLN A 1 189 ? -17.64703 -23.13793 -4.78181  1.000 40.61191 ? 189 GLN A HB3  1 
ATOM   2873 H HG2  . GLN A 1 189 ? -16.45689 -23.33814 -2.91241  1.000 40.49430 ? 189 GLN A HG2  1 
ATOM   2874 H HG3  . GLN A 1 189 ? -17.21316 -24.66934 -2.48650  1.000 40.49430 ? 189 GLN A HG3  1 
ATOM   2875 H HE21 . GLN A 1 189 ? -16.08696 -24.35561 -5.61876  1.000 48.12886 ? 189 GLN A HE21 1 
ATOM   2876 H HE22 . GLN A 1 189 ? -14.96325 -25.33142 -5.55658  1.000 48.12886 ? 189 GLN A HE22 1 
ATOM   2877 N N    . THR A 1 190 ? -20.76312 -21.59649 -3.38910  1.000 33.51519 ? 190 THR A N    1 
ATOM   2878 C CA   . THR A 1 190 ? -21.32088 -20.28608 -3.66861  1.000 38.89852 ? 190 THR A CA   1 
ATOM   2879 C C    . THR A 1 190 ? -20.87024 -19.35649 -2.55056  1.000 39.67859 ? 190 THR A C    1 
ATOM   2880 O O    . THR A 1 190 ? -20.38878 -19.80066 -1.50322  1.000 38.32744 ? 190 THR A O    1 
ATOM   2881 C CB   . THR A 1 190 ? -22.84867 -20.33425 -3.75005  1.000 41.38353 ? 190 THR A CB   1 
ATOM   2882 O OG1  . THR A 1 190 ? -23.26192 -21.41160 -4.60234  1.000 48.70767 ? 190 THR A OG1  1 
ATOM   2883 C CG2  . THR A 1 190 ? -23.39315 -19.02683 -4.31622  1.000 51.95838 ? 190 THR A CG2  1 
ATOM   2884 H H    . THR A 1 190 ? -21.09510 -21.95431 -2.68104  1.000 40.26852 ? 190 THR A H    1 
ATOM   2885 H HA   . THR A 1 190 ? -21.01236 -19.94815 -4.52390  1.000 46.72852 ? 190 THR A HA   1 
ATOM   2886 H HB   . THR A 1 190 ? -23.20874 -20.46817 -2.85937  1.000 49.71052 ? 190 THR A HB   1 
ATOM   2887 H HG1  . THR A 1 190 ? -23.00263 -21.27135 -5.38891  1.000 58.49949 ? 190 THR A HG1  1 
ATOM   2888 H HG21 . THR A 1 190 ? -24.30498 -19.15213 -4.62242  1.000 62.40035 ? 190 THR A HG21 1 
ATOM   2889 H HG22 . THR A 1 190 ? -23.38246 -18.33914 -3.63221  1.000 62.40035 ? 190 THR A HG22 1 
ATOM   2890 H HG23 . THR A 1 190 ? -22.84729 -18.73608 -5.06349  1.000 62.40035 ? 190 THR A HG23 1 
ATOM   2891 N N    . ALA A 1 191 ? -21.01269 -18.05924 -2.77607  1.000 42.19621 ? 191 ALA A N    1 
ATOM   2892 C CA   . ALA A 1 191 ? -20.74820 -17.08651 -1.72790  1.000 39.75486 ? 191 ALA A CA   1 
ATOM   2893 C C    . ALA A 1 191 ? -21.89920 -17.10045 -0.72385  1.000 34.19690 ? 191 ALA A C    1 
ATOM   2894 O O    . ALA A 1 191 ? -23.06373 -16.96409 -1.10781  1.000 35.20697 ? 191 ALA A O    1 
ATOM   2895 C CB   . ALA A 1 191 ? -20.56650 -15.69305 -2.32211  1.000 43.46784 ? 191 ALA A CB   1 
ATOM   2896 H H    . ALA A 1 191 ? -21.26064 -17.71746 -3.52527  1.000 50.68575 ? 191 ALA A H    1 
ATOM   2897 H HA   . ALA A 1 191 ? -19.92798 -17.31553 -1.26349  1.000 47.75612 ? 191 ALA A HA   1 
ATOM   2898 H HB1  . ALA A 1 191 ? -20.39110 -15.06422 -1.60468  1.000 52.21169 ? 191 ALA A HB1  1 
ATOM   2899 H HB2  . ALA A 1 191 ? -19.81823 -15.70798 -2.93918  1.000 52.21169 ? 191 ALA A HB2  1 
ATOM   2900 H HB3  . ALA A 1 191 ? -21.37732 -15.44168 -2.79144  1.000 52.21169 ? 191 ALA A HB3  1 
ATOM   2901 N N    . GLN A 1 192 ? -21.56987 -17.26658 0.55764   1.000 31.73345 ? 192 GLN A N    1 
ATOM   2902 C CA   . GLN A 1 192 ? -22.58394 -17.40493 1.59492   1.000 34.91150 ? 192 GLN A CA   1 
ATOM   2903 C C    . GLN A 1 192 ? -22.22369 -16.56840 2.81124   1.000 37.36538 ? 192 GLN A C    1 
ATOM   2904 O O    . GLN A 1 192 ? -21.06916 -16.54342 3.24701   1.000 36.98832 ? 192 GLN A O    1 
ATOM   2905 C CB   . GLN A 1 192 ? -22.75131 -18.87165 2.00549   1.000 32.55046 ? 192 GLN A CB   1 
ATOM   2906 C CG   . GLN A 1 192 ? -23.22360 -19.76254 0.87907   1.000 31.26290 ? 192 GLN A CG   1 
ATOM   2907 C CD   . GLN A 1 192 ? -23.30051 -21.21649 1.28359   1.000 27.91764 ? 192 GLN A CD   1 
ATOM   2908 O OE1  . GLN A 1 192 ? -23.99475 -21.57094 2.23196   1.000 26.57105 ? 192 GLN A OE1  1 
ATOM   2909 N NE2  . GLN A 1 192 ? -22.58534 -22.06923 0.56205   1.000 27.58979 ? 192 GLN A NE2  1 
ATOM   2910 H H    . GLN A 1 192 ? -20.76159 -17.30216 0.84921   1.000 38.13043 ? 192 GLN A H    1 
ATOM   2911 H HA   . GLN A 1 192 ? -23.42912 -17.07107 1.25564   1.000 41.94410 ? 192 GLN A HA   1 
ATOM   2912 H HB2  . GLN A 1 192 ? -21.89590 -19.20990 2.31335   1.000 39.11084 ? 192 GLN A HB2  1 
ATOM   2913 H HB3  . GLN A 1 192 ? -23.40529 -18.92383 2.71998   1.000 39.11084 ? 192 GLN A HB3  1 
ATOM   2914 H HG2  . GLN A 1 192 ? -24.10920 -19.48019 0.60175   1.000 37.56577 ? 192 GLN A HG2  1 
ATOM   2915 H HG3  . GLN A 1 192 ? -22.60424 -19.68933 0.13615   1.000 37.56577 ? 192 GLN A HG3  1 
ATOM   2916 H HE21 . GLN A 1 192 ? -22.11130 -21.78354 -0.09619  1.000 33.15804 ? 192 GLN A HE21 1 
ATOM   2917 H HE22 . GLN A 1 192 ? -22.59566 -22.90783 0.75245   1.000 33.15804 ? 192 GLN A HE22 1 
ATOM   2918 N N    . ALA A 1 193 ? -23.22880 -15.90491 3.37149   1.000 37.92176 ? 193 ALA A N    1 
ATOM   2919 C CA   . ALA A 1 193 ? -23.02950 -14.94082 4.43783   1.000 39.06148 ? 193 ALA A CA   1 
ATOM   2920 C C    . ALA A 1 193 ? -23.44733 -15.52210 5.77923   1.000 39.20305 ? 193 ALA A C    1 
ATOM   2921 O O    . ALA A 1 193 ? -24.50512 -16.14508 5.89906   1.000 37.06532 ? 193 ALA A O    1 
ATOM   2922 C CB   . ALA A 1 193 ? -23.82612 -13.66441 4.16716   1.000 47.29227 ? 193 ALA A CB   1 
ATOM   2923 H H    . ALA A 1 193 ? -24.05248 -16.00060 3.14345   1.000 45.55640 ? 193 ALA A H    1 
ATOM   2924 H HA   . ALA A 1 193 ? -22.08621 -14.72027 4.48744   1.000 46.92407 ? 193 ALA A HA   1 
ATOM   2925 H HB1  . ALA A 1 193 ? -23.47519 -13.23603 3.37077   1.000 56.80101 ? 193 ALA A HB1  1 
ATOM   2926 H HB2  . ALA A 1 193 ? -24.75859 -13.89629 4.03442   1.000 56.80101 ? 193 ALA A HB2  1 
ATOM   2927 H HB3  . ALA A 1 193 ? -23.73825 -13.06988 4.92855   1.000 56.80101 ? 193 ALA A HB3  1 
ATOM   2928 N N    . ALA A 1 194 ? -22.61869 -15.29025 6.79062   1.000 37.73875 ? 194 ALA A N    1 
ATOM   2929 C CA   . ALA A 1 194 ? -22.92997 -15.74222 8.13656   1.000 38.32106 ? 194 ALA A CA   1 
ATOM   2930 C C    . ALA A 1 194 ? -23.74160 -14.72180 8.91695   1.000 38.72576 ? 194 ALA A C    1 
ATOM   2931 O O    . ALA A 1 194 ? -24.43837 -15.09666 9.86611   1.000 35.81497 ? 194 ALA A O    1 
ATOM   2932 C CB   . ALA A 1 194 ? -21.63715 -16.06597 8.88970   1.000 36.59260 ? 194 ALA A CB   1 
ATOM   2933 H H    . ALA A 1 194 ? -21.86994 -14.87290 6.72136   1.000 45.33679 ? 194 ALA A H    1 
ATOM   2934 H HA   . ALA A 1 194 ? -23.45048 -16.55945 8.09073   1.000 46.03557 ? 194 ALA A HA   1 
ATOM   2935 H HB1  . ALA A 1 194 ? -21.85658 -16.31534 9.80106   1.000 43.96141 ? 194 ALA A HB1  1 
ATOM   2936 H HB2  . ALA A 1 194 ? -21.18806 -16.80150 8.44451   1.000 43.96141 ? 194 ALA A HB2  1 
ATOM   2937 H HB3  . ALA A 1 194 ? -21.06672 -15.28143 8.88965   1.000 43.96141 ? 194 ALA A HB3  1 
ATOM   2938 N N    . GLY A 1 195 ? -23.69330 -13.45501 8.52437   1.000 33.23119 ? 195 GLY A N    1 
ATOM   2939 C CA   . GLY A 1 195 ? -24.35187 -12.41857 9.27792   1.000 37.13725 ? 195 GLY A CA   1 
ATOM   2940 C C    . GLY A 1 195 ? -23.48912 -11.91575 10.41567  1.000 35.29908 ? 195 GLY A C    1 
ATOM   2941 O O    . GLY A 1 195 ? -22.38208 -12.39073 10.68244  1.000 30.97939 ? 195 GLY A O    1 
ATOM   2942 H H    . GLY A 1 195 ? -23.28245 -13.17681 7.82194   1.000 39.92772 ? 195 GLY A H    1 
ATOM   2943 H HA2  . GLY A 1 195 ? -24.55506 -11.67250 8.69226   1.000 44.61499 ? 195 GLY A HA2  1 
ATOM   2944 H HA3  . GLY A 1 195 ? -25.17928 -12.76401 9.64799   1.000 44.61499 ? 195 GLY A HA3  1 
ATOM   2945 N N    . THR A 1 196 ? -24.03330 -10.92253 11.10665  1.000 30.79619 ? 196 THR A N    1 
ATOM   2946 C CA   . THR A 1 196 ? -23.30233 -10.24633 12.16243  1.000 29.75640 ? 196 THR A CA   1 
ATOM   2947 C C    . THR A 1 196 ? -22.78106 -11.23871 13.18785  1.000 28.62615 ? 196 THR A C    1 
ATOM   2948 O O    . THR A 1 196 ? -23.51117 -12.11096 13.66333  1.000 28.14472 ? 196 THR A O    1 
ATOM   2949 C CB   . THR A 1 196 ? -24.21186 -9.21889  12.83266  1.000 34.20903 ? 196 THR A CB   1 
ATOM   2950 O OG1  . THR A 1 196 ? -24.86453 -8.43743  11.82370  1.000 32.55267 ? 196 THR A OG1  1 
ATOM   2951 C CG2  . THR A 1 196 ? -23.40740 -8.31818  13.75132  1.000 35.96361 ? 196 THR A CG2  1 
ATOM   2952 H H    . THR A 1 196 ? -24.82890 -10.62096 10.98145  1.000 37.00572 ? 196 THR A H    1 
ATOM   2953 H HA   . THR A 1 196 ? -22.53911 -9.78478  11.78117  1.000 35.75797 ? 196 THR A HA   1 
ATOM   2954 H HB   . THR A 1 196 ? -24.88210 -9.66863  13.37064  1.000 41.10112 ? 196 THR A HB   1 
ATOM   2955 H HG1  . THR A 1 196 ? -24.30730 -8.19242  11.24485  1.000 39.11350 ? 196 THR A HG1  1 
ATOM   2956 H HG21 . THR A 1 196 ? -23.98890 -7.66016  14.16334  1.000 43.20662 ? 196 THR A HG21 1 
ATOM   2957 H HG22 . THR A 1 196 ? -22.98602 -8.84587  14.44766  1.000 43.20662 ? 196 THR A HG22 1 
ATOM   2958 H HG23 . THR A 1 196 ? -22.71961 -7.85773  13.24553  1.000 43.20662 ? 196 THR A HG23 1 
ATOM   2959 N N    . ASP A 1 197 ? -21.50616 -11.08168 13.54156  1.000 29.13995 ? 197 ASP A N    1 
ATOM   2960 C CA   . ASP A 1 197 ? -20.82614 -11.96741 14.47903  1.000 28.48677 ? 197 ASP A CA   1 
ATOM   2961 C C    . ASP A 1 197 ? -20.95280 -11.39626 15.88821  1.000 30.72615 ? 197 ASP A C    1 
ATOM   2962 O O    . ASP A 1 197 ? -20.04484 -10.75856 16.42301  1.000 32.22153 ? 197 ASP A O    1 
ATOM   2963 C CB   . ASP A 1 197 ? -19.37053 -12.12291 14.05997  1.000 32.62089 ? 197 ASP A CB   1 
ATOM   2964 C CG   . ASP A 1 197 ? -18.60486 -13.08157 14.93004  1.000 32.49954 ? 197 ASP A CG   1 
ATOM   2965 O OD1  . ASP A 1 197 ? -19.23795 -13.87022 15.66231  1.000 27.21580 ? 197 ASP A OD1  1 
ATOM   2966 O OD2  . ASP A 1 197 ? -17.35822 -13.03651 14.87797  1.000 40.21550 ? 197 ASP A OD2  1 
ATOM   2967 H H    . ASP A 1 197 ? -21.00199 -10.45211 13.24315  1.000 35.01823 ? 197 ASP A H    1 
ATOM   2968 H HA   . ASP A 1 197 ? -21.25680 -12.83656 14.47576  1.000 34.23442 ? 197 ASP A HA   1 
ATOM   2969 H HB2  . ASP A 1 197 ? -19.33899 -12.45587 13.14945  1.000 39.19536 ? 197 ASP A HB2  1 
ATOM   2970 H HB3  . ASP A 1 197 ? -18.93384 -11.25835 14.11238  1.000 39.19536 ? 197 ASP A HB3  1 
ATOM   2971 N N    . THR A 1 198 ? -22.09613 -11.64838 16.50944  1.000 28.58307 ? 198 THR A N    1 
ATOM   2972 C CA   . THR A 1 198 ? -22.32594 -11.09701 17.83727  1.000 30.03287 ? 198 THR A CA   1 
ATOM   2973 C C    . THR A 1 198 ? -21.48479 -11.83171 18.87558  1.000 30.56957 ? 198 THR A C    1 
ATOM   2974 O O    . THR A 1 198 ? -21.11458 -12.99629 18.70966  1.000 30.30745 ? 198 THR A O    1 
ATOM   2975 C CB   . THR A 1 198 ? -23.80714 -11.16256 18.18855  1.000 36.67522 ? 198 THR A CB   1 
ATOM   2976 O OG1  . THR A 1 198 ? -24.17850 -12.51611 18.46622  1.000 38.94015 ? 198 THR A OG1  1 
ATOM   2977 C CG2  . THR A 1 198 ? -24.63815 -10.64813 17.02363  1.000 37.50192 ? 198 THR A CG2  1 
ATOM   2978 H H    . THR A 1 198 ? -22.73919 -12.12354 16.19273  1.000 34.34997 ? 198 THR A H    1 
ATOM   2979 H HA   . THR A 1 198 ? -22.06382 -10.16330 17.85678  1.000 36.08974 ? 198 THR A HA   1 
ATOM   2980 H HB   . THR A 1 198 ? -23.98288 -10.61481 18.96957  1.000 44.06056 ? 198 THR A HB   1 
ATOM   2981 H HG1  . THR A 1 198 ? -24.90249 -12.53386 18.89181  1.000 46.77847 ? 198 THR A HG1  1 
ATOM   2982 H HG21 . THR A 1 198 ? -25.41099 -10.16482 17.35532  1.000 45.05260 ? 198 THR A HG21 1 
ATOM   2983 H HG22 . THR A 1 198 ? -24.10585 -10.05169 16.47424  1.000 45.05260 ? 198 THR A HG22 1 
ATOM   2984 H HG23 . THR A 1 198 ? -24.94151 -11.39115 16.47885  1.000 45.05260 ? 198 THR A HG23 1 
ATOM   2985 N N    . THR A 1 199 ? -21.16802 -11.11809 19.94893  1.000 28.09208 ? 199 THR A N    1 
ATOM   2986 C CA   . THR A 1 199 ? -20.28973 -11.62549 20.98957  1.000 28.13611 ? 199 THR A CA   1 
ATOM   2987 C C    . THR A 1 199 ? -21.06974 -12.32029 22.09504  1.000 26.71091 ? 199 THR A C    1 
ATOM   2988 O O    . THR A 1 199 ? -22.13858 -11.86158 22.51088  1.000 27.33995 ? 199 THR A O    1 
ATOM   2989 C CB   . THR A 1 199 ? -19.47245 -10.46903 21.56616  1.000 27.82283 ? 199 THR A CB   1 
ATOM   2990 O OG1  . THR A 1 199 ? -18.71623 -9.86583  20.50971  1.000 27.85478 ? 199 THR A OG1  1 
ATOM   2991 C CG2  . THR A 1 199 ? -18.53672 -10.95484 22.63457  1.000 28.87244 ? 199 THR A CG2  1 
ATOM   2992 H H    . THR A 1 199 ? -21.45569 -10.32160 20.09877  1.000 33.76079 ? 199 THR A H    1 
ATOM   2993 H HA   . THR A 1 199 ? -19.69159 -12.28928 20.61208  1.000 33.81363 ? 199 THR A HA   1 
ATOM   2994 H HB   . THR A 1 199 ? -20.06656 -9.81483  21.96611  1.000 33.43768 ? 199 THR A HB   1 
ATOM   2995 H HG1  . THR A 1 199 ? -19.23260 -9.48185  19.96978  1.000 33.47603 ? 199 THR A HG1  1 
ATOM   2996 H HG21 . THR A 1 199 ? -17.99023 -10.22066 22.95587  1.000 34.69721 ? 199 THR A HG21 1 
ATOM   2997 H HG22 . THR A 1 199 ? -19.04236 -11.31959 23.37767  1.000 34.69721 ? 199 THR A HG22 1 
ATOM   2998 H HG23 . THR A 1 199 ? -17.95712 -11.64639 22.27859  1.000 34.69721 ? 199 THR A HG23 1 
ATOM   2999 N N    . ILE A 1 200 ? -20.50927 -13.42765 22.57944  1.000 24.28981 ? 200 ILE A N    1 
ATOM   3000 C CA   . ILE A 1 200 ? -21.12686 -14.25175 23.61337  1.000 22.93324 ? 200 ILE A CA   1 
ATOM   3001 C C    . ILE A 1 200 ? -20.92152 -13.61571 24.98750  1.000 22.13949 ? 200 ILE A C    1 
ATOM   3002 O O    . ILE A 1 200 ? -19.96310 -13.92881 25.70135  1.000 21.73818 ? 200 ILE A O    1 
ATOM   3003 C CB   . ILE A 1 200 ? -20.54702 -15.67879 23.56970  1.000 22.28274 ? 200 ILE A CB   1 
ATOM   3004 C CG1  . ILE A 1 200 ? -20.58650 -16.25776 22.14880  1.000 22.77133 ? 200 ILE A CG1  1 
ATOM   3005 C CG2  . ILE A 1 200 ? -21.29253 -16.57164 24.54362  1.000 24.56550 ? 200 ILE A CG2  1 
ATOM   3006 C CD1  . ILE A 1 200 ? -19.63119 -17.44183 21.96792  1.000 21.66689 ? 200 ILE A CD1  1 
ATOM   3007 H H    . ILE A 1 200 ? -19.74854 -13.73079 22.31678  1.000 29.19807 ? 200 ILE A H    1 
ATOM   3008 H HA   . ILE A 1 200 ? -22.08341 -14.29167 23.45740  1.000 27.57017 ? 200 ILE A HA   1 
ATOM   3009 H HB   . ILE A 1 200 ? -19.61521 -15.63430 23.83548  1.000 26.78958 ? 200 ILE A HB   1 
ATOM   3010 H HG12 . ILE A 1 200 ? -21.48635 -16.56529 21.95752  1.000 27.37589 ? 200 ILE A HG12 1 
ATOM   3011 H HG13 . ILE A 1 200 ? -20.33120 -15.56622 21.51834  1.000 27.37589 ? 200 ILE A HG13 1 
ATOM   3012 H HG21 . ILE A 1 200 ? -22.24385 -16.50892 24.36483  1.000 29.52890 ? 200 ILE A HG21 1 
ATOM   3013 H HG22 . ILE A 1 200 ? -20.99340 -17.48678 24.42556  1.000 29.52890 ? 200 ILE A HG22 1 
ATOM   3014 H HG23 . ILE A 1 200 ? -21.10591 -16.27680 25.44869  1.000 29.52890 ? 200 ILE A HG23 1 
ATOM   3015 H HD11 . ILE A 1 200 ? -18.80657 -17.12405 21.56803  1.000 26.05055 ? 200 ILE A HD11 1 
ATOM   3016 H HD12 . ILE A 1 200 ? -19.44800 -17.83518 22.83545  1.000 26.05055 ? 200 ILE A HD12 1 
ATOM   3017 H HD13 . ILE A 1 200 ? -20.04827 -18.09843 21.38843  1.000 26.05055 ? 200 ILE A HD13 1 
ATOM   3018 N N    . THR A 1 201 ? -21.84759 -12.74449 25.37474  1.000 24.27552 ? 201 THR A N    1 
ATOM   3019 C CA   . THR A 1 201 ? -21.69921 -11.96362 26.59990  1.000 21.61766 ? 201 THR A CA   1 
ATOM   3020 C C    . THR A 1 201 ? -21.40722 -12.82239 27.82560  1.000 21.62135 ? 201 THR A C    1 
ATOM   3021 O O    . THR A 1 201 ? -20.51098 -12.50610 28.61927  1.000 21.13169 ? 201 THR A O    1 
ATOM   3022 C CB   . THR A 1 201 ? -22.97520 -11.15412 26.80300  1.000 24.74503 ? 201 THR A CB   1 
ATOM   3023 O OG1  . THR A 1 201 ? -23.30184 -10.51697 25.56221  1.000 23.32044 ? 201 THR A OG1  1 
ATOM   3024 C CG2  . THR A 1 201 ? -22.80609 -10.12366 27.89598  1.000 26.05253 ? 201 THR A CG2  1 
ATOM   3025 H H    . THR A 1 201 ? -22.57528 -12.58469 24.94516  1.000 29.18092 ? 201 THR A H    1 
ATOM   3026 H HA   . THR A 1 201 ? -20.93897 -11.36939 26.50076  1.000 25.99148 ? 201 THR A HA   1 
ATOM   3027 H HB   . THR A 1 201 ? -23.70099 -11.73520 27.07951  1.000 29.74432 ? 201 THR A HB   1 
ATOM   3028 H HG1  . THR A 1 201 ? -23.87085 -9.91254  25.69068  1.000 28.03481 ? 201 THR A HG1  1 
ATOM   3029 H HG21 . THR A 1 201 ? -22.60345 -10.56234 28.73705  1.000 31.31333 ? 201 THR A HG21 1 
ATOM   3030 H HG22 . THR A 1 201 ? -22.08052 -9.51968  27.67313  1.000 31.31333 ? 201 THR A HG22 1 
ATOM   3031 H HG23 . THR A 1 201 ? -23.62296 -9.61049  27.99739  1.000 31.31333 ? 201 THR A HG23 1 
ATOM   3032 N N    . VAL A 1 202 ? -22.18873 -13.87988 28.03003  1.000 21.36972 ? 202 VAL A N    1 
ATOM   3033 C CA   . VAL A 1 202 ? -22.00870 -14.65556 29.25345  1.000 21.70996 ? 202 VAL A CA   1 
ATOM   3034 C C    . VAL A 1 202 ? -20.60217 -15.23021 29.31392  1.000 22.12673 ? 202 VAL A C    1 
ATOM   3035 O O    . VAL A 1 202 ? -20.05609 -15.44133 30.40386  1.000 22.37651 ? 202 VAL A O    1 
ATOM   3036 C CB   . VAL A 1 202 ? -23.06571 -15.76561 29.36347  1.000 22.48445 ? 202 VAL A CB   1 
ATOM   3037 C CG1  . VAL A 1 202 ? -22.94555 -16.76091 28.21371  1.000 26.95785 ? 202 VAL A CG1  1 
ATOM   3038 C CG2  . VAL A 1 202 ? -22.92276 -16.45617 30.69116  1.000 26.22801 ? 202 VAL A CG2  1 
ATOM   3039 H H    . VAL A 1 202 ? -22.80500 -14.15814 27.49863  1.000 25.69396 ? 202 VAL A H    1 
ATOM   3040 H HA   . VAL A 1 202 ? -22.13235 -14.05877 30.00807  1.000 26.10225 ? 202 VAL A HA   1 
ATOM   3041 H HB   . VAL A 1 202 ? -23.95069 -15.37282 29.30487  1.000 27.03163 ? 202 VAL A HB   1 
ATOM   3042 H HG11 . VAL A 1 202 ? -23.65659 -17.41652 28.28794  1.000 32.39971 ? 202 VAL A HG11 1 
ATOM   3043 H HG12 . VAL A 1 202 ? -23.02260 -16.28313 27.37307  1.000 32.39971 ? 202 VAL A HG12 1 
ATOM   3044 H HG13 . VAL A 1 202 ? -22.08284 -17.20124 28.26606  1.000 32.39971 ? 202 VAL A HG13 1 
ATOM   3045 H HG21 . VAL A 1 202 ? -22.14876 -17.04009 30.66170  1.000 31.52391 ? 202 VAL A HG21 1 
ATOM   3046 H HG22 . VAL A 1 202 ? -22.80640 -15.78740 31.38406  1.000 31.52391 ? 202 VAL A HG22 1 
ATOM   3047 H HG23 . VAL A 1 202 ? -23.72303 -16.97621 30.86443  1.000 31.52391 ? 202 VAL A HG23 1 
ATOM   3048 N N    . ASN A 1 203 ? -20.00027 -15.51722 28.14880  1.000 22.94779 ? 203 ASN A N    1 
ATOM   3049 C CA   . ASN A 1 203 ? -18.65736 -16.08390 28.11850  1.000 22.16902 ? 203 ASN A CA   1 
ATOM   3050 C C    . ASN A 1 203 ? -17.62144 -15.02541 28.45560  1.000 21.58708 ? 203 ASN A C    1 
ATOM   3051 O O    . ASN A 1 203 ? -16.63184 -15.30297 29.14442  1.000 22.68557 ? 203 ASN A O    1 
ATOM   3052 C CB   . ASN A 1 203 ? -18.33915 -16.67994 26.74532  1.000 22.51415 ? 203 ASN A CB   1 
ATOM   3053 C CG   . ASN A 1 203 ? -19.07336 -17.98112 26.46823  1.000 24.38066 ? 203 ASN A CG   1 
ATOM   3054 O OD1  . ASN A 1 203 ? -19.89802 -18.44113 27.25828  1.000 23.44959 ? 203 ASN A OD1  1 
ATOM   3055 N ND2  . ASN A 1 203 ? -18.78139 -18.57463 25.31638  1.000 24.89961 ? 203 ASN A ND2  1 
ATOM   3056 H H    . ASN A 1 203 ? -20.34946 -15.39233 27.37287  1.000 27.58764 ? 203 ASN A H    1 
ATOM   3057 H HA   . ASN A 1 203 ? -18.62028 -16.79973 28.77204  1.000 26.65312 ? 203 ASN A HA   1 
ATOM   3058 H HB2  . ASN A 1 203 ? -18.59436 -16.04275 26.05994  1.000 27.06727 ? 203 ASN A HB2  1 
ATOM   3059 H HB3  . ASN A 1 203 ? -17.38719 -16.85894 26.69396  1.000 27.06727 ? 203 ASN A HB3  1 
ATOM   3060 H HD21 . ASN A 1 203 ? -19.16543 -19.31432 25.10431  1.000 29.92983 ? 203 ASN A HD21 1 
ATOM   3061 H HD22 . ASN A 1 203 ? -18.20831 -18.21922 24.78266  1.000 29.92983 ? 203 ASN A HD22 1 
ATOM   3062 N N    . VAL A 1 204 ? -17.82014 -13.80375 27.96774  1.000 21.55509 ? 204 VAL A N    1 
ATOM   3063 C CA   . VAL A 1 204 ? -16.90979 -12.73020 28.33428  1.000 20.38011 ? 204 VAL A CA   1 
ATOM   3064 C C    . VAL A 1 204 ? -16.90440 -12.54995 29.84686  1.000 21.93603 ? 204 VAL A C    1 
ATOM   3065 O O    . VAL A 1 204 ? -15.84829 -12.40042 30.46973  1.000 21.24229 ? 204 VAL A O    1 
ATOM   3066 C CB   . VAL A 1 204 ? -17.28305 -11.42798 27.61082  1.000 21.98725 ? 204 VAL A CB   1 
ATOM   3067 C CG1  . VAL A 1 204 ? -16.36552 -10.30933 28.05837  1.000 22.69001 ? 204 VAL A CG1  1 
ATOM   3068 C CG2  . VAL A 1 204 ? -17.20707 -11.63400 26.11185  1.000 22.34576 ? 204 VAL A CG2  1 
ATOM   3069 H H    . VAL A 1 204 ? -18.45811 -13.57820 27.43696  1.000 25.91640 ? 204 VAL A H    1 
ATOM   3070 H HA   . VAL A 1 204 ? -16.01413 -12.97393 28.05270  1.000 24.50643 ? 204 VAL A HA   1 
ATOM   3071 H HB   . VAL A 1 204 ? -18.19267 -11.17442 27.83262  1.000 26.43499 ? 204 VAL A HB   1 
ATOM   3072 H HG11 . VAL A 1 204 ? -16.37365 -10.26274 29.02721  1.000 27.27831 ? 204 VAL A HG11 1 
ATOM   3073 H HG12 . VAL A 1 204 ? -15.46662 -10.49315 27.74358  1.000 27.27831 ? 204 VAL A HG12 1 
ATOM   3074 H HG13 . VAL A 1 204 ? -16.68230 -9.47231  27.68429  1.000 27.27831 ? 204 VAL A HG13 1 
ATOM   3075 H HG21 . VAL A 1 204 ? -17.07812 -10.77451 25.68109  1.000 26.86521 ? 204 VAL A HG21 1 
ATOM   3076 H HG22 . VAL A 1 204 ? -16.46059 -12.21995 25.91105  1.000 26.86521 ? 204 VAL A HG22 1 
ATOM   3077 H HG23 . VAL A 1 204 ? -18.03500 -12.03637 25.80602  1.000 26.86521 ? 204 VAL A HG23 1 
ATOM   3078 N N    . LEU A 1 205 ? -18.09061 -12.54561 30.45708  1.000 20.69610 ? 205 LEU A N    1 
ATOM   3079 C CA   . LEU A 1 205 ? -18.16404 -12.42802 31.90975  1.000 21.31514 ? 205 LEU A CA   1 
ATOM   3080 C C    . LEU A 1 205 ? -17.46295 -13.59834 32.58767  1.000 22.40374 ? 205 LEU A C    1 
ATOM   3081 O O    . LEU A 1 205 ? -16.73366 -13.41124 33.56888  1.000 25.08394 ? 205 LEU A O    1 
ATOM   3082 C CB   . LEU A 1 205 ? -19.62318 -12.33487 32.34820  1.000 20.88080 ? 205 LEU A CB   1 
ATOM   3083 C CG   . LEU A 1 205 ? -20.34612 -11.10345 31.79698  1.000 23.48796 ? 205 LEU A CG   1 
ATOM   3084 C CD1  . LEU A 1 205 ? -21.85424 -11.14524 32.07164  1.000 26.72789 ? 205 LEU A CD1  1 
ATOM   3085 C CD2  . LEU A 1 205 ? -19.75120 -9.82168  32.38540  1.000 25.54428 ? 205 LEU A CD2  1 
ATOM   3086 H H    . LEU A 1 205 ? -18.85113 -12.60815 30.06046  1.000 24.88561 ? 205 LEU A H    1 
ATOM   3087 H HA   . LEU A 1 205 ? -17.71791 -11.61309 32.18860  1.000 25.62846 ? 205 LEU A HA   1 
ATOM   3088 H HB2  . LEU A 1 205 ? -20.09457 -13.12263 32.03494  1.000 25.10725 ? 205 LEU A HB2  1 
ATOM   3089 H HB3  . LEU A 1 205 ? -19.65638 -12.29163 33.31667  1.000 25.10725 ? 205 LEU A HB3  1 
ATOM   3090 H HG   . LEU A 1 205 ? -20.22400 -11.10076 30.83470  1.000 28.23584 ? 205 LEU A HG   1 
ATOM   3091 H HD11 . LEU A 1 205 ? -22.28001 -10.40637 31.60939  1.000 32.12376 ? 205 LEU A HD11 1 
ATOM   3092 H HD12 . LEU A 1 205 ? -22.21091 -11.98733 31.74826  1.000 32.12376 ? 205 LEU A HD12 1 
ATOM   3093 H HD13 . LEU A 1 205 ? -22.00352 -11.06785 33.02695  1.000 32.12376 ? 205 LEU A HD13 1 
ATOM   3094 H HD21 . LEU A 1 205 ? -19.71807 -9.90338  33.35138  1.000 30.70343 ? 205 LEU A HD21 1 
ATOM   3095 H HD22 . LEU A 1 205 ? -18.85596 -9.69827  32.03297  1.000 30.70343 ? 205 LEU A HD22 1 
ATOM   3096 H HD23 . LEU A 1 205 ? -20.31138 -9.07007  32.13603  1.000 30.70343 ? 205 LEU A HD23 1 
ATOM   3097 N N    . ALA A 1 206 ? -17.67519 -14.81494 32.08835  1.000 22.86597 ? 206 ALA A N    1 
ATOM   3098 C CA   . ALA A 1 206 ? -16.99297 -15.95968 32.67647  1.000 24.10587 ? 206 ALA A CA   1 
ATOM   3099 C C    . ALA A 1 206 ? -15.48358 -15.76510 32.64145  1.000 24.82582 ? 206 ALA A C    1 
ATOM   3100 O O    . ALA A 1 206 ? -14.78098 -16.08353 33.60759  1.000 25.92687 ? 206 ALA A O    1 
ATOM   3101 C CB   . ALA A 1 206 ? -17.38792 -17.23789 31.94088  1.000 24.05776 ? 206 ALA A CB   1 
ATOM   3102 H H    . ALA A 1 206 ? -18.19495 -14.99790 31.42806  1.000 27.48946 ? 206 ALA A H    1 
ATOM   3103 H HA   . ALA A 1 206 ? -17.26664 -16.05233 33.60244  1.000 28.97733 ? 206 ALA A HA   1 
ATOM   3104 H HB1  . ALA A 1 206 ? -17.13595 -17.15595 31.00777  1.000 28.91961 ? 206 ALA A HB1  1 
ATOM   3105 H HB2  . ALA A 1 206 ? -16.92570 -17.98963 32.34354  1.000 28.91961 ? 206 ALA A HB2  1 
ATOM   3106 H HB3  . ALA A 1 206 ? -18.34719 -17.36126 32.01487  1.000 28.91961 ? 206 ALA A HB3  1 
ATOM   3107 N N    . TRP A 1 207 ? -14.97338 -15.21389 31.53538  1.000 24.86444 ? 207 TRP A N    1 
ATOM   3108 C CA   . TRP A 1 207 ? -13.53462 -15.02198 31.35725  1.000 25.50876 ? 207 TRP A CA   1 
ATOM   3109 C C    . TRP A 1 207 ? -13.01593 -13.87486 32.21587  1.000 26.02654 ? 207 TRP A C    1 
ATOM   3110 O O    . TRP A 1 207 ? -11.90203 -13.96153 32.74712  1.000 26.37269 ? 207 TRP A O    1 
ATOM   3111 C CB   . TRP A 1 207 ? -13.26031 -14.82812 29.85911  1.000 25.13843 ? 207 TRP A CB   1 
ATOM   3112 C CG   . TRP A 1 207 ? -11.88862 -14.32830 29.46625  1.000 26.13264 ? 207 TRP A CG   1 
ATOM   3113 C CD1  . TRP A 1 207 ? -10.74934 -15.06514 29.26572  1.000 28.25441 ? 207 TRP A CD1  1 
ATOM   3114 C CD2  . TRP A 1 207 ? -11.53938 -12.97201 29.18942  1.000 26.52466 ? 207 TRP A CD2  1 
ATOM   3115 N NE1  . TRP A 1 207 ? -9.71202  -14.23881 28.89481  1.000 28.69431 ? 207 TRP A NE1  1 
ATOM   3116 C CE2  . TRP A 1 207 ? -10.17430 -12.94939 28.83913  1.000 28.44440 ? 207 TRP A CE2  1 
ATOM   3117 C CE3  . TRP A 1 207 ? -12.25281 -11.77246 29.20482  1.000 28.00601 ? 207 TRP A CE3  1 
ATOM   3118 C CZ2  . TRP A 1 207 ? -9.50969  -11.76963 28.51513  1.000 29.10388 ? 207 TRP A CZ2  1 
ATOM   3119 C CZ3  . TRP A 1 207 ? -11.59345 -10.60519 28.88307  1.000 28.65835 ? 207 TRP A CZ3  1 
ATOM   3120 C CH2  . TRP A 1 207 ? -10.23858 -10.61098 28.53928  1.000 30.17536 ? 207 TRP A CH2  1 
ATOM   3121 H H    . TRP A 1 207 ? -15.44306 -14.94076 30.86875  1.000 29.88762 ? 207 TRP A H    1 
ATOM   3122 H HA   . TRP A 1 207 ? -13.03697 -15.80419 31.64256  1.000 30.66081 ? 207 TRP A HA   1 
ATOM   3123 H HB2  . TRP A 1 207 ? -13.38399 -15.68408 29.41986  1.000 30.21641 ? 207 TRP A HB2  1 
ATOM   3124 H HB3  . TRP A 1 207 ? -13.90185 -14.18495 29.51903  1.000 30.21641 ? 207 TRP A HB3  1 
ATOM   3125 H HD1  . TRP A 1 207 ? -10.68655 -15.98763 29.36560  1.000 33.95559 ? 207 TRP A HD1  1 
ATOM   3126 H HE1  . TRP A 1 207 ? -8.90709  -14.49015 28.72597  1.000 34.48347 ? 207 TRP A HE1  1 
ATOM   3127 H HE3  . TRP A 1 207 ? -13.15560 -11.76081 29.42783  1.000 33.65751 ? 207 TRP A HE3  1 
ATOM   3128 H HZ2  . TRP A 1 207 ? -8.60702  -11.76870 28.29132  1.000 34.97494 ? 207 TRP A HZ2  1 
ATOM   3129 H HZ3  . TRP A 1 207 ? -12.05828 -9.79978  28.89497  1.000 34.44031 ? 207 TRP A HZ3  1 
ATOM   3130 H HH2  . TRP A 1 207 ? -9.82222  -9.80836  28.32171  1.000 36.26072 ? 207 TRP A HH2  1 
ATOM   3131 N N    . LEU A 1 208 ? -13.81710 -12.82730 32.41863  1.000 25.22762 ? 208 LEU A N    1 
ATOM   3132 C CA   . LEU A 1 208 ? -13.49336 -11.84217 33.45081  1.000 25.15791 ? 208 LEU A CA   1 
ATOM   3133 C C    . LEU A 1 208 ? -13.45461 -12.47829 34.84313  1.000 26.85296 ? 208 LEU A C    1 
ATOM   3134 O O    . LEU A 1 208 ? -12.61427 -12.11129 35.67399  1.000 29.94883 ? 208 LEU A O    1 
ATOM   3135 C CB   . LEU A 1 208 ? -14.49996 -10.69203 33.40957  1.000 25.46711 ? 208 LEU A CB   1 
ATOM   3136 C CG   . LEU A 1 208 ? -14.40025 -9.79112  32.17558  1.000 25.38426 ? 208 LEU A CG   1 
ATOM   3137 C CD1  . LEU A 1 208 ? -15.48829 -8.72074  32.12157  1.000 24.90583 ? 208 LEU A CD1  1 
ATOM   3138 C CD2  . LEU A 1 208 ? -13.03287 -9.12016  32.12136  1.000 26.88303 ? 208 LEU A CD2  1 
ATOM   3139 H H    . LEU A 1 208 ? -14.53988 -12.66643 31.98122  1.000 30.32343 ? 208 LEU A H    1 
ATOM   3140 H HA   . LEU A 1 208 ? -12.61269 -11.47888 33.26824  1.000 30.23978 ? 208 LEU A HA   1 
ATOM   3141 H HB2  . LEU A 1 208 ? -15.39450 -11.06677 33.42576  1.000 30.61083 ? 208 LEU A HB2  1 
ATOM   3142 H HB3  . LEU A 1 208 ? -14.35991 -10.13388 34.19044  1.000 30.61083 ? 208 LEU A HB3  1 
ATOM   3143 H HG   . LEU A 1 208 ? -14.52430 -10.36117 31.40063  1.000 30.51141 ? 208 LEU A HG   1 
ATOM   3144 H HD11 . LEU A 1 208 ? -15.18613 -7.93841  32.60897  1.000 29.93729 ? 208 LEU A HD11 1 
ATOM   3145 H HD12 . LEU A 1 208 ? -15.65704 -8.48844  31.19503  1.000 29.93729 ? 208 LEU A HD12 1 
ATOM   3146 H HD13 . LEU A 1 208 ? -16.29664 -9.07137  32.52718  1.000 29.93729 ? 208 LEU A HD13 1 
ATOM   3147 H HD21 . LEU A 1 208 ? -13.09389 -8.32280  31.57237  1.000 32.30993 ? 208 LEU A HD21 1 
ATOM   3148 H HD22 . LEU A 1 208 ? -12.76209 -8.88187  33.02180  1.000 32.30993 ? 208 LEU A HD22 1 
ATOM   3149 H HD23 . LEU A 1 208 ? -12.39262 -9.73874  31.73620  1.000 32.30993 ? 208 LEU A HD23 1 
ATOM   3150 N N    . TYR A 1 209 ? -14.36068 -13.42314 35.12637  1.000 26.54113 ? 209 TYR A N    1 
ATOM   3151 C CA   . TYR A 1 209 ? -14.28028 -14.13538 36.40109  1.000 27.06305 ? 209 TYR A CA   1 
ATOM   3152 C C    . TYR A 1 209 ? -13.01900 -14.98166 36.46881  1.000 30.51981 ? 209 TYR A C    1 
ATOM   3153 O O    . TYR A 1 209 ? -12.35187 -15.03257 37.50899  1.000 32.77685 ? 209 TYR A O    1 
ATOM   3154 C CB   . TYR A 1 209 ? -15.50896 -15.01858 36.61686  1.000 26.55838 ? 209 TYR A CB   1 
ATOM   3155 C CG   . TYR A 1 209 ? -16.67255 -14.27163 37.20455  1.000 29.51329 ? 209 TYR A CG   1 
ATOM   3156 C CD1  . TYR A 1 209 ? -16.67384 -13.87431 38.53581  1.000 32.39514 ? 209 TYR A CD1  1 
ATOM   3157 C CD2  . TYR A 1 209 ? -17.76979 -13.95656 36.42654  1.000 27.52089 ? 209 TYR A CD2  1 
ATOM   3158 C CE1  . TYR A 1 209 ? -17.73542 -13.17982 39.06660  1.000 34.11096 ? 209 TYR A CE1  1 
ATOM   3159 C CE2  . TYR A 1 209 ? -18.83059 -13.27163 36.94723  1.000 29.52297 ? 209 TYR A CE2  1 
ATOM   3160 C CZ   . TYR A 1 209 ? -18.81449 -12.88689 38.26568  1.000 31.84662 ? 209 TYR A CZ   1 
ATOM   3161 O OH   . TYR A 1 209 ? -19.88155 -12.19381 38.77659  1.000 29.85860 ? 209 TYR A OH   1 
ATOM   3162 H H    . TYR A 1 209 ? -15.00883 -13.66089 34.61356  1.000 31.89964 ? 209 TYR A H    1 
ATOM   3163 H HA   . TYR A 1 209 ? -14.26197 -13.47705 37.11326  1.000 32.52595 ? 209 TYR A HA   1 
ATOM   3164 H HB2  . TYR A 1 209 ? -15.78820 -15.38363 35.76265  1.000 31.92034 ? 209 TYR A HB2  1 
ATOM   3165 H HB3  . TYR A 1 209 ? -15.27688 -15.73771 37.22505  1.000 31.92034 ? 209 TYR A HB3  1 
ATOM   3166 H HD1  . TYR A 1 209 ? -15.94575 -14.08116 39.07617  1.000 38.92446 ? 209 TYR A HD1  1 
ATOM   3167 H HD2  . TYR A 1 209 ? -17.78643 -14.21515 35.53337  1.000 33.07536 ? 209 TYR A HD2  1 
ATOM   3168 H HE1  . TYR A 1 209 ? -17.72386 -12.91130 39.95691  1.000 40.98344 ? 209 TYR A HE1  1 
ATOM   3169 H HE2  . TYR A 1 209 ? -19.56181 -13.06631 36.41051  1.000 35.47785 ? 209 TYR A HE2  1 
ATOM   3170 H HH   . TYR A 1 209 ? -20.57961 -12.38634 38.35086  1.000 35.88061 ? 209 TYR A HH   1 
ATOM   3171 N N    . ALA A 1 210 ? -12.68317 -15.66389 35.36927  1.000 30.69554 ? 210 ALA A N    1 
ATOM   3172 C CA   . ALA A 1 210 ? -11.44580 -16.42969 35.32505  1.000 31.06382 ? 210 ALA A CA   1 
ATOM   3173 C C    . ALA A 1 210 ? -10.24992 -15.53317 35.60432  1.000 31.07105 ? 210 ALA A C    1 
ATOM   3174 O O    . ALA A 1 210 ? -9.31279  -15.93169 36.30709  1.000 34.99746 ? 210 ALA A O    1 
ATOM   3175 C CB   . ALA A 1 210 ? -11.29138 -17.10756 33.96322  1.000 33.74089 ? 210 ALA A CB   1 
ATOM   3176 H H    . ALA A 1 210 ? -13.15042 -15.69660 34.64801  1.000 36.88493 ? 210 ALA A H    1 
ATOM   3177 H HA   . ALA A 1 210 ? -11.48036 -17.12320 36.00236  1.000 37.32687 ? 210 ALA A HA   1 
ATOM   3178 H HB1  . ALA A 1 210 ? -11.08566 -16.43368 33.29654  1.000 40.53936 ? 210 ALA A HB1  1 
ATOM   3179 H HB2  . ALA A 1 210 ? -10.57065 -17.75487 34.01258  1.000 40.53936 ? 210 ALA A HB2  1 
ATOM   3180 H HB3  . ALA A 1 210 ? -12.12214 -17.55414 33.73674  1.000 40.53936 ? 210 ALA A HB3  1 
ATOM   3181 N N    . ALA A 1 211 ? -10.27108 -14.31497 35.05332  1.000 30.07883 ? 211 ALA A N    1 
ATOM   3182 C CA   . ALA A 1 211 ? -9.18299  -13.36719 35.27347  1.000 31.49161 ? 211 ALA A CA   1 
ATOM   3183 C C    . ALA A 1 211 ? -9.03419  -13.03399 36.75017  1.000 36.84210 ? 211 ALA A C    1 
ATOM   3184 O O    . ALA A 1 211 ? -7.91453  -12.89133 37.25166  1.000 38.34616 ? 211 ALA A O    1 
ATOM   3185 C CB   . ALA A 1 211 ? -9.43007  -12.08758 34.47369  1.000 33.60980 ? 211 ALA A CB   1 
ATOM   3186 H H    . ALA A 1 211 ? -10.90188 -14.01639 34.55077  1.000 36.14489 ? 211 ALA A H    1 
ATOM   3187 H HA   . ALA A 1 211 ? -8.35646  -13.76887 34.96300  1.000 37.84023 ? 211 ALA A HA   1 
ATOM   3188 H HB1  . ALA A 1 211 ? -8.62975  -11.54007 34.49865  1.000 40.38205 ? 211 ALA A HB1  1 
ATOM   3189 H HB2  . ALA A 1 211 ? -9.64067  -12.32395 33.55680  1.000 40.38205 ? 211 ALA A HB2  1 
ATOM   3190 H HB3  . ALA A 1 211 ? -10.17287 -11.60588 34.87007  1.000 40.38205 ? 211 ALA A HB3  1 
ATOM   3191 N N    . VAL A 1 212 ? -10.15259 -12.88119 37.45880  1.000 35.79325 ? 212 VAL A N    1 
ATOM   3192 C CA   . VAL A 1 212 ? -10.07937 -12.59094 38.88466  1.000 36.90632 ? 212 VAL A CA   1 
ATOM   3193 C C    . VAL A 1 212 ? -9.64856  -13.83294 39.65679  1.000 34.17827 ? 212 VAL A C    1 
ATOM   3194 O O    . VAL A 1 212 ? -8.81973  -13.75296 40.57125  1.000 38.14619 ? 212 VAL A O    1 
ATOM   3195 C CB   . VAL A 1 212 ? -11.42620 -12.03883 39.38244  1.000 37.53251 ? 212 VAL A CB   1 
ATOM   3196 C CG1  . VAL A 1 212 ? -11.44696 -11.93016 40.89986  1.000 41.19556 ? 212 VAL A CG1  1 
ATOM   3197 C CG2  . VAL A 1 212 ? -11.70529 -10.67990 38.74048  1.000 38.27784 ? 212 VAL A CG2  1 
ATOM   3198 H H    . VAL A 1 212 ? -10.95010 -12.93982 37.14236  1.000 43.00218 ? 212 VAL A H    1 
ATOM   3199 H HA   . VAL A 1 212 ? -9.40787  -11.90645 39.03113  1.000 44.33787 ? 212 VAL A HA   1 
ATOM   3200 H HB   . VAL A 1 212 ? -12.13009 -12.65418 39.12399  1.000 45.08930 ? 212 VAL A HB   1 
ATOM   3201 H HG11 . VAL A 1 212 ? -10.54412 -12.04088 41.23677  1.000 49.48496 ? 212 VAL A HG11 1 
ATOM   3202 H HG12 . VAL A 1 212 ? -11.78838 -11.05718 41.14931  1.000 49.48496 ? 212 VAL A HG12 1 
ATOM   3203 H HG13 . VAL A 1 212 ? -12.02131 -12.62477 41.25838  1.000 49.48496 ? 212 VAL A HG13 1 
ATOM   3204 H HG21 . VAL A 1 212 ? -12.47407 -10.27767 39.17417  1.000 45.98370 ? 212 VAL A HG21 1 
ATOM   3205 H HG22 . VAL A 1 212 ? -10.92720 -10.11172 38.85298  1.000 45.98370 ? 212 VAL A HG22 1 
ATOM   3206 H HG23 . VAL A 1 212 ? -11.88756 -10.80807 37.79642  1.000 45.98370 ? 212 VAL A HG23 1 
ATOM   3207 N N    . ILE A 1 213 ? -10.19492 -14.99803 39.30605  1.000 38.46907 ? 213 ILE A N    1 
ATOM   3208 C CA   . ILE A 1 213 ? -9.75144  -16.22741 39.95911  1.000 36.87749 ? 213 ILE A CA   1 
ATOM   3209 C C    . ILE A 1 213 ? -8.23972  -16.37198 39.85718  1.000 40.60858 ? 213 ILE A C    1 
ATOM   3210 O O    . ILE A 1 213 ? -7.60175  -16.96290 40.73798  1.000 40.54351 ? 213 ILE A O    1 
ATOM   3211 C CB   . ILE A 1 213 ? -10.49014 -17.44390 39.35536  1.000 39.58599 ? 213 ILE A CB   1 
ATOM   3212 C CG1  . ILE A 1 213 ? -11.94361 -17.45467 39.84370  1.000 36.74079 ? 213 ILE A CG1  1 
ATOM   3213 C CG2  . ILE A 1 213 ? -9.77837  -18.74012 39.71825  1.000 40.27409 ? 213 ILE A CG2  1 
ATOM   3214 C CD1  . ILE A 1 213 ? -12.85171 -18.43167 39.12246  1.000 40.61389 ? 213 ILE A CD1  1 
ATOM   3215 H H    . ILE A 1 213 ? -10.80638 -15.10030 38.71001  1.000 46.21318 ? 213 ILE A H    1 
ATOM   3216 H HA   . ILE A 1 213 ? -9.97984  -16.18418 40.90085  1.000 44.30328 ? 213 ILE A HA   1 
ATOM   3217 H HB   . ILE A 1 213 ? -10.48684 -17.36793 38.38834  1.000 47.55348 ? 213 ILE A HB   1 
ATOM   3218 H HG12 . ILE A 1 213 ? -11.95021 -17.69098 40.78445  1.000 44.13924 ? 213 ILE A HG12 1 
ATOM   3219 H HG13 . ILE A 1 213 ? -12.31550 -16.56710 39.72197  1.000 44.13924 ? 213 ILE A HG13 1 
ATOM   3220 H HG21 . ILE A 1 213 ? -9.52177  -18.70845 40.65316  1.000 48.37920 ? 213 ILE A HG21 1 
ATOM   3221 H HG22 . ILE A 1 213 ? -10.38103 -19.48472 39.56570  1.000 48.37920 ? 213 ILE A HG22 1 
ATOM   3222 H HG23 . ILE A 1 213 ? -8.98946  -18.83370 39.16170  1.000 48.37920 ? 213 ILE A HG23 1 
ATOM   3223 H HD11 . ILE A 1 213 ? -12.96591 -18.13834 38.20495  1.000 48.78696 ? 213 ILE A HD11 1 
ATOM   3224 H HD12 . ILE A 1 213 ? -12.44552 -19.31235 39.14005  1.000 48.78696 ? 213 ILE A HD12 1 
ATOM   3225 H HD13 . ILE A 1 213 ? -13.71108 -18.45472 39.57175  1.000 48.78696 ? 213 ILE A HD13 1 
ATOM   3226 N N    . ASN A 1 214 ? -7.63881  -15.79555 38.80812  1.000 37.78444 ? 214 ASN A N    1 
ATOM   3227 C CA   . ASN A 1 214 ? -6.22491  -15.95725 38.48995  1.000 41.18935 ? 214 ASN A CA   1 
ATOM   3228 C C    . ASN A 1 214 ? -5.41632  -14.67627 38.69296  1.000 38.97404 ? 214 ASN A C    1 
ATOM   3229 O O    . ASN A 1 214 ? -4.30674  -14.55881 38.16243  1.000 39.91201 ? 214 ASN A O    1 
ATOM   3230 C CB   . ASN A 1 214 ? -6.06487  -16.44594 37.04758  1.000 39.11922 ? 214 ASN A CB   1 
ATOM   3231 C CG   . ASN A 1 214 ? -6.38630  -17.91492 36.89354  1.000 38.04687 ? 214 ASN A CG   1 
ATOM   3232 O OD1  . ASN A 1 214 ? -5.53278  -18.77187 37.11361  1.000 40.67672 ? 214 ASN A OD1  1 
ATOM   3233 N ND2  . ASN A 1 214 ? -7.62171  -18.21372 36.51208  1.000 36.24663 ? 214 ASN A ND2  1 
ATOM   3234 H H    . ASN A 1 214 ? -8.04971  -15.28814 38.24839  1.000 45.39162 ? 214 ASN A H    1 
ATOM   3235 H HA   . ASN A 1 214 ? -5.86082  -16.62727 39.08946  1.000 49.47751 ? 214 ASN A HA   1 
ATOM   3236 H HB2  . ASN A 1 214 ? -6.66626  -15.94485 36.47475  1.000 46.99336 ? 214 ASN A HB2  1 
ATOM   3237 H HB3  . ASN A 1 214 ? -5.14686  -16.30790 36.76634  1.000 46.99336 ? 214 ASN A HB3  1 
ATOM   3238 H HD21 . ASN A 1 214 ? -7.85340  -19.03565 36.41038  1.000 43.54624 ? 214 ASN A HD21 1 
ATOM   3239 H HD22 . ASN A 1 214 ? -8.19063  -17.58543 36.36658  1.000 43.54624 ? 214 ASN A HD22 1 
ATOM   3240 N N    . GLY A 1 215 ? -5.95924  -13.70676 39.42549  1.000 42.10514 ? 215 GLY A N    1 
ATOM   3241 C CA   . GLY A 1 215 ? -5.17736  -12.59410 39.92221  1.000 38.49935 ? 215 GLY A CA   1 
ATOM   3242 C C    . GLY A 1 215 ? -5.28755  -11.28545 39.17041  1.000 42.89591 ? 215 GLY A C    1 
ATOM   3243 O O    . GLY A 1 215 ? -4.68934  -10.29629 39.60865  1.000 46.33645 ? 215 GLY A O    1 
ATOM   3244 H H    . GLY A 1 215 ? -6.78954  -13.67648 39.64750  1.000 50.57646 ? 215 GLY A H    1 
ATOM   3245 H HA2  . GLY A 1 215 ? -5.44595  -12.42155 40.83817  1.000 46.24951 ? 215 GLY A HA2  1 
ATOM   3246 H HA3  . GLY A 1 215 ? -4.24264  -12.85307 39.91065  1.000 46.24951 ? 215 GLY A HA3  1 
ATOM   3247 N N    . ASP A 1 216 ? -6.01597  -11.23995 38.05422  1.000 41.07242 ? 216 ASP A N    1 
ATOM   3248 C CA   . ASP A 1 216 ? -6.16028  -10.01592 37.26697  1.000 42.66914 ? 216 ASP A CA   1 
ATOM   3249 C C    . ASP A 1 216 ? -7.42148  -9.28588  37.72009  1.000 46.14168 ? 216 ASP A C    1 
ATOM   3250 O O    . ASP A 1 216 ? -8.53634  -9.77750  37.51248  1.000 46.48585 ? 216 ASP A O    1 
ATOM   3251 C CB   . ASP A 1 216 ? -6.23400  -10.32747 35.77302  1.000 43.80163 ? 216 ASP A CB   1 
ATOM   3252 C CG   . ASP A 1 216 ? -4.86766  -10.49302 35.13201  1.000 48.36673 ? 216 ASP A CG   1 
ATOM   3253 O OD1  . ASP A 1 216 ? -3.84672  -10.15739 35.76810  1.000 60.00370 ? 216 ASP A OD1  1 
ATOM   3254 O OD2  . ASP A 1 216 ? -4.82237  -10.96413 33.97472  1.000 44.69379 ? 216 ASP A OD2  1 
ATOM   3255 H H    . ASP A 1 216 ? -6.44091  -11.91326 37.72914  1.000 49.33720 ? 216 ASP A H    1 
ATOM   3256 H HA   . ASP A 1 216 ? -5.38948  -9.44932  37.42733  1.000 51.25326 ? 216 ASP A HA   1 
ATOM   3257 H HB2  . ASP A 1 216 ? -6.72492  -11.15462 35.64764  1.000 52.61225 ? 216 ASP A HB2  1 
ATOM   3258 H HB3  . ASP A 1 216 ? -6.68947  -9.59967  35.32162  1.000 52.61225 ? 216 ASP A HB3  1 
ATOM   3259 N N    . ARG A 1 217 ? -7.25315  -8.09845  38.31221  1.000 46.71805 ? 217 ARG A N    1 
ATOM   3260 C CA   . ARG A 1 217 ? -8.37669  -7.41975  38.94592  1.000 42.12024 ? 217 ARG A CA   1 
ATOM   3261 C C    . ARG A 1 217 ? -8.42705  -5.91960  38.67002  1.000 42.32114 ? 217 ARG A C    1 
ATOM   3262 O O    . ARG A 1 217 ? -9.27569  -5.23029  39.25306  1.000 41.28863 ? 217 ARG A O    1 
ATOM   3263 C CB   . ARG A 1 217 ? -8.32963  -7.67497  40.46338  1.000 38.66369 ? 217 ARG A CB   1 
ATOM   3264 H H    . ARG A 1 217 ? -6.50649  -7.67415  38.35760  1.000 56.11195 ? 217 ARG A H    1 
ATOM   3265 H HA   . ARG A 1 217 ? -9.20220  -7.78283  38.58869  1.000 50.59458 ? 217 ARG A HA   1 
ATOM   3266 N N    . TRP A 1 218 ? -7.58501  -5.39661  37.77212  1.000 41.46093 ? 218 TRP A N    1 
ATOM   3267 C CA   . TRP A 1 218 ? -7.51349  -3.95341  37.57281  1.000 43.64941 ? 218 TRP A CA   1 
ATOM   3268 C C    . TRP A 1 218 ? -8.80717  -3.37262  37.01857  1.000 42.01313 ? 218 TRP A C    1 
ATOM   3269 O O    . TRP A 1 218 ? -9.06245  -2.17437  37.19491  1.000 42.17794 ? 218 TRP A O    1 
ATOM   3270 C CB   . TRP A 1 218 ? -6.35965  -3.59775  36.62302  1.000 48.01928 ? 218 TRP A CB   1 
ATOM   3271 C CG   . TRP A 1 218 ? -6.48371  -4.15441  35.22344  1.000 42.82435 ? 218 TRP A CG   1 
ATOM   3272 C CD1  . TRP A 1 218 ? -5.95531  -5.32408  34.76362  1.000 40.81008 ? 218 TRP A CD1  1 
ATOM   3273 C CD2  . TRP A 1 218 ? -7.15871  -3.55357  34.10308  1.000 43.89047 ? 218 TRP A CD2  1 
ATOM   3274 N NE1  . TRP A 1 218 ? -6.25747  -5.49336  33.43442  1.000 39.14277 ? 218 TRP A NE1  1 
ATOM   3275 C CE2  . TRP A 1 218 ? -6.99980  -4.42414  33.00585  1.000 42.21237 ? 218 TRP A CE2  1 
ATOM   3276 C CE3  . TRP A 1 218 ? -7.88191  -2.36915  33.92493  1.000 45.31705 ? 218 TRP A CE3  1 
ATOM   3277 C CZ2  . TRP A 1 218 ? -7.54042  -4.15149  31.74852  1.000 41.13903 ? 218 TRP A CZ2  1 
ATOM   3278 C CZ3  . TRP A 1 218 ? -8.41989  -2.10085  32.67441  1.000 42.16224 ? 218 TRP A CZ3  1 
ATOM   3279 C CH2  . TRP A 1 218 ? -8.24386  -2.98656  31.60308  1.000 42.36652 ? 218 TRP A CH2  1 
ATOM   3280 H H    . TRP A 1 218 ? -7.05279  -5.85270  37.27379  1.000 49.80340 ? 218 TRP A H    1 
ATOM   3281 H HA   . TRP A 1 218 ? -7.33969  -3.54513  38.43537  1.000 52.42959 ? 218 TRP A HA   1 
ATOM   3282 H HB2  . TRP A 1 218 ? -6.31155  -2.63189  36.54759  1.000 57.67343 ? 218 TRP A HB2  1 
ATOM   3283 H HB3  . TRP A 1 218 ? -5.53511  -3.94255  37.00005  1.000 57.67343 ? 218 TRP A HB3  1 
ATOM   3284 H HD1  . TRP A 1 218 ? -5.46095  -5.92189  35.27658  1.000 49.02239 ? 218 TRP A HD1  1 
ATOM   3285 H HE1  . TRP A 1 218 ? -6.01924  -6.16240  32.94941  1.000 47.02161 ? 218 TRP A HE1  1 
ATOM   3286 H HE3  . TRP A 1 218 ? -7.99957  -1.77416  34.62994  1.000 54.43075 ? 218 TRP A HE3  1 
ATOM   3287 H HZ2  . TRP A 1 218 ? -7.42701  -4.73902  31.03658  1.000 49.41713 ? 218 TRP A HZ2  1 
ATOM   3288 H HZ3  . TRP A 1 218 ? -8.90622  -1.31879  32.54494  1.000 50.64497 ? 218 TRP A HZ3  1 
ATOM   3289 H HH2  . TRP A 1 218 ? -8.61301  -2.77834  30.77527  1.000 50.89012 ? 218 TRP A HH2  1 
ATOM   3290 N N    . PHE A 1 219 ? -9.61459  -4.18607  36.33949  1.000 41.06761 ? 219 PHE A N    1 
ATOM   3291 C CA   . PHE A 1 219 ? -10.82264 -3.71156  35.67802  1.000 38.08894 ? 219 PHE A CA   1 
ATOM   3292 C C    . PHE A 1 219 ? -12.01567 -3.63982  36.61796  1.000 38.73828 ? 219 PHE A C    1 
ATOM   3293 O O    . PHE A 1 219 ? -13.04478 -3.06199  36.24775  1.000 36.37835 ? 219 PHE A O    1 
ATOM   3294 C CB   . PHE A 1 219 ? -11.15027 -4.62535  34.48739  1.000 39.34528 ? 219 PHE A CB   1 
ATOM   3295 C CG   . PHE A 1 219 ? -11.08334 -6.08494  34.82363  1.000 35.35880 ? 219 PHE A CG   1 
ATOM   3296 C CD1  . PHE A 1 219 ? -12.18263 -6.73885  35.34693  1.000 31.78176 ? 219 PHE A CD1  1 
ATOM   3297 C CD2  . PHE A 1 219 ? -9.90471  -6.78948  34.65578  1.000 37.79140 ? 219 PHE A CD2  1 
ATOM   3298 C CE1  . PHE A 1 219 ? -12.11107 -8.07163  35.68218  1.000 34.73690 ? 219 PHE A CE1  1 
ATOM   3299 C CE2  . PHE A 1 219 ? -9.82650  -8.11986  34.99370  1.000 37.19980 ? 219 PHE A CE2  1 
ATOM   3300 C CZ   . PHE A 1 219 ? -10.93060 -8.76327  35.50435  1.000 35.54523 ? 219 PHE A CZ   1 
ATOM   3301 H H    . PHE A 1 219 ? -9.48058  -5.03050  36.24691  1.000 49.33142 ? 219 PHE A H    1 
ATOM   3302 H HA   . PHE A 1 219 ? -10.66759 -2.81797  35.33398  1.000 45.75702 ? 219 PHE A HA   1 
ATOM   3303 H HB2  . PHE A 1 219 ? -12.04996 -4.43108  34.18124  1.000 47.26463 ? 219 PHE A HB2  1 
ATOM   3304 H HB3  . PHE A 1 219 ? -10.51351 -4.45397  33.77602  1.000 47.26463 ? 219 PHE A HB3  1 
ATOM   3305 H HD1  . PHE A 1 219 ? -12.97806 -6.27394  35.47369  1.000 38.18840 ? 219 PHE A HD1  1 
ATOM   3306 H HD2  . PHE A 1 219 ? -9.15663  -6.35824  34.31037  1.000 45.39998 ? 219 PHE A HD2  1 
ATOM   3307 H HE1  . PHE A 1 219 ? -12.85739 -8.50549  36.02812  1.000 41.73457 ? 219 PHE A HE1  1 
ATOM   3308 H HE2  . PHE A 1 219 ? -9.02905  -8.58402  34.87743  1.000 44.69005 ? 219 PHE A HE2  1 
ATOM   3309 H HZ   . PHE A 1 219 ? -10.88103 -9.66423  35.72955  1.000 42.70456 ? 219 PHE A HZ   1 
ATOM   3310 N N    . LEU A 1 220 ? -11.90604 -4.22227  37.81108  1.000 36.84270 ? 220 LEU A N    1 
ATOM   3311 C CA   . LEU A 1 220 ? -12.96137 -4.11992  38.80918  1.000 37.66348 ? 220 LEU A CA   1 
ATOM   3312 C C    . LEU A 1 220 ? -13.12548 -2.67397  39.25192  1.000 39.44266 ? 220 LEU A C    1 
ATOM   3313 O O    . LEU A 1 220 ? -12.15201 -2.01324  39.62679  1.000 41.68161 ? 220 LEU A O    1 
ATOM   3314 C CB   . LEU A 1 220 ? -12.62626 -4.99691  40.01317  1.000 35.33759 ? 220 LEU A CB   1 
ATOM   3315 C CG   . LEU A 1 220 ? -12.43120 -6.48609  39.73157  1.000 38.25746 ? 220 LEU A CG   1 
ATOM   3316 C CD1  . LEU A 1 220 ? -12.10582 -7.24330  41.01570  1.000 41.39632 ? 220 LEU A CD1  1 
ATOM   3317 C CD2  . LEU A 1 220 ? -13.66694 -7.06940  39.06716  1.000 37.39614 ? 220 LEU A CD2  1 
ATOM   3318 H H    . LEU A 1 220 ? -11.22690 -4.68396  38.06644  1.000 44.26153 ? 220 LEU A H    1 
ATOM   3319 H HA   . LEU A 1 220 ? -13.79875 -4.42641  38.42740  1.000 45.24646 ? 220 LEU A HA   1 
ATOM   3320 H HB2  . LEU A 1 220 ? -11.80131 -4.66929  40.40435  1.000 42.45540 ? 220 LEU A HB2  1 
ATOM   3321 H HB3  . LEU A 1 220 ? -13.35077 -4.91935  40.65346  1.000 42.45540 ? 220 LEU A HB3  1 
ATOM   3322 H HG   . LEU A 1 220 ? -11.68207 -6.59331  39.12477  1.000 45.95924 ? 220 LEU A HG   1 
ATOM   3323 H HD11 . LEU A 1 220 ? -11.22109 -6.98569  41.31867  1.000 49.72588 ? 220 LEU A HD11 1 
ATOM   3324 H HD12 . LEU A 1 220 ? -12.76513 -7.01830  41.69067  1.000 49.72588 ? 220 LEU A HD12 1 
ATOM   3325 H HD13 . LEU A 1 220 ? -12.12922 -8.19604  40.83507  1.000 49.72588 ? 220 LEU A HD13 1 
ATOM   3326 H HD21 . LEU A 1 220 ? -13.55823 -8.02987  38.98596  1.000 44.92566 ? 220 LEU A HD21 1 
ATOM   3327 H HD22 . LEU A 1 220 ? -14.44327 -6.86938  39.61324  1.000 44.92566 ? 220 LEU A HD22 1 
ATOM   3328 H HD23 . LEU A 1 220 ? -13.76983 -6.67267  38.18800  1.000 44.92566 ? 220 LEU A HD23 1 
ATOM   3329 N N    . ASN A 1 221 ? -14.35726 -2.18715  39.23183  1.000 43.20349 ? 221 ASN A N    1 
ATOM   3330 C CA   . ASN A 1 221 ? -14.62072 -0.79787  39.56749  1.000 39.10828 ? 221 ASN A CA   1 
ATOM   3331 C C    . ASN A 1 221 ? -15.61436 -0.70004  40.72600  1.000 39.78155 ? 221 ASN A C    1 
ATOM   3332 O O    . ASN A 1 221 ? -15.96986 -1.69821  41.35931  1.000 38.62158 ? 221 ASN A O    1 
ATOM   3333 C CB   . ASN A 1 221 ? -15.11347 -0.05101  38.32542  1.000 35.58627 ? 221 ASN A CB   1 
ATOM   3334 C CG   . ASN A 1 221 ? -16.45351 -0.54738  37.84282  1.000 38.39900 ? 221 ASN A CG   1 
ATOM   3335 O OD1  . ASN A 1 221 ? -17.22156 -1.15663  38.59181  1.000 37.38811 ? 221 ASN A OD1  1 
ATOM   3336 N ND2  . ASN A 1 221 ? -16.75427 -0.27031  36.58221  1.000 40.78375 ? 221 ASN A ND2  1 
ATOM   3337 H H    . ASN A 1 221 ? -15.05673 -2.64346  39.02660  1.000 51.89448 ? 221 ASN A H    1 
ATOM   3338 H HA   . ASN A 1 221 ? -13.79234 -0.39470  39.87103  1.000 46.98022 ? 221 ASN A HA   1 
ATOM   3339 H HB2  . ASN A 1 221 ? -15.20063 0.89167   38.53673  1.000 42.75382 ? 221 ASN A HB2  1 
ATOM   3340 H HB3  . ASN A 1 221 ? -14.47205 -0.17225  37.60794  1.000 42.75382 ? 221 ASN A HB3  1 
ATOM   3341 H HD21 . ASN A 1 221 ? -17.50542 -0.52862  36.25259  1.000 48.99079 ? 221 ASN A HD21 1 
ATOM   3342 H HD22 . ASN A 1 221 ? -16.19829 0.16779   36.09380  1.000 48.99079 ? 221 ASN A HD22 1 
ATOM   3343 N N    . ARG A 1 222 ? -16.04551 0.53095   41.00926  1.000 40.78479 ? 222 ARG A N    1 
ATOM   3344 C CA   . ARG A 1 222 ? -16.94356 0.83036   42.11487  1.000 45.51887 ? 222 ARG A CA   1 
ATOM   3345 C C    . ARG A 1 222 ? -18.40144 0.93003   41.68225  1.000 42.98102 ? 222 ARG A C    1 
ATOM   3346 O O    . ARG A 1 222 ? -19.24717 1.34479   42.48272  1.000 38.97636 ? 222 ARG A O    1 
ATOM   3347 C CB   . ARG A 1 222 ? -16.51786 2.13788   42.79300  1.000 40.95658 ? 222 ARG A CB   1 
ATOM   3348 H H    . ARG A 1 222 ? -15.82190 1.22822   40.55823  1.000 48.99203 ? 222 ARG A H    1 
ATOM   3349 H HA   . ARG A 1 222 ? -16.87669 0.11298   42.76433  1.000 54.67293 ? 222 ARG A HA   1 
ATOM   3350 N N    . PHE A 1 223 ? -18.71178 0.55277   40.44513  1.000 38.43917 ? 223 PHE A N    1 
ATOM   3351 C CA   . PHE A 1 223 ? -20.04517 0.69237   39.88606  1.000 35.40111 ? 223 PHE A CA   1 
ATOM   3352 C C    . PHE A 1 223 ? -20.79696 -0.63416  39.89209  1.000 33.35901 ? 223 PHE A C    1 
ATOM   3353 O O    . PHE A 1 223 ? -20.21180 -1.71789  39.95667  1.000 32.01556 ? 223 PHE A O    1 
ATOM   3354 C CB   . PHE A 1 223 ? -19.99597 1.18757   38.43238  1.000 41.62417 ? 223 PHE A CB   1 
ATOM   3355 C CG   . PHE A 1 223 ? -19.41267 2.55504   38.25452  1.000 51.11125 ? 223 PHE A CG   1 
ATOM   3356 C CD1  . PHE A 1 223 ? -18.04092 2.73617   38.22166  1.000 50.20037 ? 223 PHE A CD1  1 
ATOM   3357 C CD2  . PHE A 1 223 ? -20.23706 3.65468   38.06035  1.000 60.02973 ? 223 PHE A CD2  1 
ATOM   3358 C CE1  . PHE A 1 223 ? -17.49947 3.99356   38.03297  1.000 54.66580 ? 223 PHE A CE1  1 
ATOM   3359 C CE2  . PHE A 1 223 ? -19.70326 4.91620   37.86866  1.000 58.18833 ? 223 PHE A CE2  1 
ATOM   3360 C CZ   . PHE A 1 223 ? -18.33167 5.08681   37.85527  1.000 63.81360 ? 223 PHE A CZ   1 
ATOM   3361 H H    . PHE A 1 223 ? -18.14802 0.20356   39.89756  1.000 46.17729 ? 223 PHE A H    1 
ATOM   3362 H HA   . PHE A 1 223 ? -20.51972 1.33572   40.43542  1.000 42.53163 ? 223 PHE A HA   1 
ATOM   3363 H HB2  . PHE A 1 223 ? -19.45538 0.57035   37.91499  1.000 49.99930 ? 223 PHE A HB2  1 
ATOM   3364 H HB3  . PHE A 1 223 ? -20.90083 1.20883   38.08356  1.000 49.99930 ? 223 PHE A HB3  1 
ATOM   3365 H HD1  . PHE A 1 223 ? -17.47753 2.00388   38.32769  1.000 60.29073 ? 223 PHE A HD1  1 
ATOM   3366 H HD2  . PHE A 1 223 ? -21.16018 3.54181   38.05911  1.000 72.08597 ? 223 PHE A HD2  1 
ATOM   3367 H HE1  . PHE A 1 223 ? -16.57631 4.10587   38.02527  1.000 65.64925 ? 223 PHE A HE1  1 
ATOM   3368 H HE2  . PHE A 1 223 ? -20.26544 5.64735   37.74916  1.000 69.87629 ? 223 PHE A HE2  1 
ATOM   3369 H HZ   . PHE A 1 223 ? -17.96840 5.93331   37.72731  1.000 76.62661 ? 223 PHE A HZ   1 
ATOM   3370 N N    . THR A 1 224 ? -22.11544 -0.52812  39.78614  1.000 29.99634 ? 224 THR A N    1 
ATOM   3371 C CA   . THR A 1 224 ? -22.94527 -1.65390  39.40953  1.000 27.85465 ? 224 THR A CA   1 
ATOM   3372 C C    . THR A 1 224 ? -23.89836 -1.20110  38.31141  1.000 28.90689 ? 224 THR A C    1 
ATOM   3373 O O    . THR A 1 224 ? -23.86473 -0.05005  37.86354  1.000 29.69933 ? 224 THR A O    1 
ATOM   3374 C CB   . THR A 1 224 ? -23.73542 -2.21623  40.59277  1.000 29.17672 ? 224 THR A CB   1 
ATOM   3375 O OG1  . THR A 1 224 ? -24.25956 -3.49838  40.22289  1.000 27.10138 ? 224 THR A OG1  1 
ATOM   3376 C CG2  . THR A 1 224 ? -24.88062 -1.28745  40.95563  1.000 28.31363 ? 224 THR A CG2  1 
ATOM   3377 H H    . THR A 1 224 ? -22.55390 0.19753   39.93034  1.000 36.04590 ? 224 THR A H    1 
ATOM   3378 H HA   . THR A 1 224 ? -22.37118 -2.36064  39.07511  1.000 33.47587 ? 224 THR A HA   1 
ATOM   3379 H HB   . THR A 1 224 ? -23.16097 -2.30270  41.36957  1.000 35.06235 ? 224 THR A HB   1 
ATOM   3380 H HG1  . THR A 1 224 ? -24.56062 -3.89219  40.90103  1.000 32.57195 ? 224 THR A HG1  1 
ATOM   3381 H HG21 . THR A 1 224 ? -25.64153 -1.45785  40.37867  1.000 34.02664 ? 224 THR A HG21 1 
ATOM   3382 H HG22 . THR A 1 224 ? -25.14582 -1.43216  41.87738  1.000 34.02664 ? 224 THR A HG22 1 
ATOM   3383 H HG23 . THR A 1 224 ? -24.60512 -0.36357  40.84867  1.000 34.02664 ? 224 THR A HG23 1 
ATOM   3384 N N    . THR A 1 225 ? -24.75512 -2.11586  37.87723  1.000 28.46541 ? 225 THR A N    1 
ATOM   3385 C CA   . THR A 1 225 ? -25.72153 -1.80863  36.83452  1.000 28.76857 ? 225 THR A CA   1 
ATOM   3386 C C    . THR A 1 225 ? -26.90346 -2.76152  36.96818  1.000 28.26139 ? 225 THR A C    1 
ATOM   3387 O O    . THR A 1 225 ? -26.99779 -3.54171  37.92070  1.000 27.70123 ? 225 THR A O    1 
ATOM   3388 C CB   . THR A 1 225 ? -25.05814 -1.88870  35.45290  1.000 31.10903 ? 225 THR A CB   1 
ATOM   3389 O OG1  . THR A 1 225 ? -25.95431 -1.38435  34.45605  1.000 32.44558 ? 225 THR A OG1  1 
ATOM   3390 C CG2  . THR A 1 225 ? -24.67581 -3.32316  35.11236  1.000 30.24033 ? 225 THR A CG2  1 
ATOM   3391 H H    . THR A 1 225 ? -24.79599 -2.92283  38.17174  1.000 34.20878 ? 225 THR A H    1 
ATOM   3392 H HA   . THR A 1 225 ? -26.06259 -0.90930  36.96014  1.000 34.57258 ? 225 THR A HA   1 
ATOM   3393 H HB   . THR A 1 225 ? -24.24787 -1.35547  35.45869  1.000 37.38112 ? 225 THR A HB   1 
ATOM   3394 H HG1  . THR A 1 225 ? -25.91753 -0.54543  34.43467  1.000 38.98498 ? 225 THR A HG1  1 
ATOM   3395 H HG21 . THR A 1 225 ? -25.47482 -3.86008  34.99315  1.000 36.33868 ? 225 THR A HG21 1 
ATOM   3396 H HG22 . THR A 1 225 ? -24.15812 -3.34276  34.29229  1.000 36.33868 ? 225 THR A HG22 1 
ATOM   3397 H HG23 . THR A 1 225 ? -24.14466 -3.70401  35.82912  1.000 36.33868 ? 225 THR A HG23 1 
ATOM   3398 N N    . THR A 1 226 ? -27.82860 -2.65679  36.01264  1.000 31.98456 ? 226 THR A N    1 
ATOM   3399 C CA   . THR A 1 226 ? -28.98556 -3.52823  35.89176  1.000 32.66363 ? 226 THR A CA   1 
ATOM   3400 C C    . THR A 1 226 ? -28.90079 -4.27801  34.56945  1.000 31.94332 ? 226 THR A C    1 
ATOM   3401 O O    . THR A 1 226 ? -28.18055 -3.87117  33.65261  1.000 32.26394 ? 226 THR A O    1 
ATOM   3402 C CB   . THR A 1 226 ? -30.30733 -2.74675  35.92770  1.000 32.67400 ? 226 THR A CB   1 
ATOM   3403 O OG1  . THR A 1 226 ? -30.38949 -1.88625  34.78294  1.000 32.39313 ? 226 THR A OG1  1 
ATOM   3404 C CG2  . THR A 1 226 ? -30.41471 -1.91531  37.19515  1.000 38.20094 ? 226 THR A CG2  1 
ATOM   3405 H H    . THR A 1 226 ? -27.80164 -2.05817  35.39578  1.000 38.43176 ? 226 THR A H    1 
ATOM   3406 H HA   . THR A 1 226 ? -28.98646 -4.15520  36.63190  1.000 39.24664 ? 226 THR A HA   1 
ATOM   3407 H HB   . THR A 1 226 ? -31.04813 -3.37284  35.91662  1.000 39.25908 ? 226 THR A HB   1 
ATOM   3408 H HG1  . THR A 1 226 ? -29.95595 -1.18042  34.92238  1.000 38.92205 ? 226 THR A HG1  1 
ATOM   3409 H HG21 . THR A 1 226 ? -31.16541 -1.30462  37.12870  1.000 45.89142 ? 226 THR A HG21 1 
ATOM   3410 H HG22 . THR A 1 226 ? -30.54712 -2.49468  37.96176  1.000 45.89142 ? 226 THR A HG22 1 
ATOM   3411 H HG23 . THR A 1 226 ? -29.60194 -1.40208  37.32509  1.000 45.89142 ? 226 THR A HG23 1 
ATOM   3412 N N    . LEU A 1 227 ? -29.66642 -5.36779  34.46270  1.000 35.08449 ? 227 LEU A N    1 
ATOM   3413 C CA   . LEU A 1 227 ? -29.67748 -6.13254  33.22057  1.000 33.13621 ? 227 LEU A CA   1 
ATOM   3414 C C    . LEU A 1 227 ? -30.09555 -5.25393  32.04708  1.000 34.95568 ? 227 LEU A C    1 
ATOM   3415 O O    . LEU A 1 227 ? -29.41748 -5.21553  31.01364  1.000 33.33474 ? 227 LEU A O    1 
ATOM   3416 C CB   . LEU A 1 227 ? -30.61584 -7.33448  33.33275  1.000 35.11323 ? 227 LEU A CB   1 
ATOM   3417 C CG   . LEU A 1 227 ? -30.14427 -8.57583  34.08475  1.000 34.77548 ? 227 LEU A CG   1 
ATOM   3418 C CD1  . LEU A 1 227 ? -31.18720 -9.67330  33.97158  1.000 35.62005 ? 227 LEU A CD1  1 
ATOM   3419 C CD2  . LEU A 1 227 ? -28.81746 -9.08371  33.54925  1.000 35.81049 ? 227 LEU A CD2  1 
ATOM   3420 H H    . LEU A 1 227 ? -30.17641 -5.67656  35.08251  1.000 42.15168 ? 227 LEU A H    1 
ATOM   3421 H HA   . LEU A 1 227 ? -28.78067 -6.46634  33.06178  1.000 39.81375 ? 227 LEU A HA   1 
ATOM   3422 H HB2  . LEU A 1 227 ? -31.42169 -7.03276  33.78049  1.000 42.18617 ? 227 LEU A HB2  1 
ATOM   3423 H HB3  . LEU A 1 227 ? -30.82585 -7.62388  32.43106  1.000 42.18617 ? 227 LEU A HB3  1 
ATOM   3424 H HG   . LEU A 1 227 ? -30.01811 -8.33839  35.01674  1.000 41.78087 ? 227 LEU A HG   1 
ATOM   3425 H HD11 . LEU A 1 227 ? -31.14389 -10.05969 33.08292  1.000 42.79435 ? 227 LEU A HD11 1 
ATOM   3426 H HD12 . LEU A 1 227 ? -31.00288 -10.35401 34.63759  1.000 42.79435 ? 227 LEU A HD12 1 
ATOM   3427 H HD13 . LEU A 1 227 ? -32.06565 -9.29105  34.12362  1.000 42.79435 ? 227 LEU A HD13 1 
ATOM   3428 H HD21 . LEU A 1 227 ? -28.09725 -8.58349  33.96394  1.000 43.02288 ? 227 LEU A HD21 1 
ATOM   3429 H HD22 . LEU A 1 227 ? -28.73095 -10.02612 33.76204  1.000 43.02288 ? 227 LEU A HD22 1 
ATOM   3430 H HD23 . LEU A 1 227 ? -28.79626 -8.95844  32.58761  1.000 43.02288 ? 227 LEU A HD23 1 
ATOM   3431 N N    . ASN A 1 228 ? -31.21170 -4.53693  32.19123  1.000 37.98841 ? 228 ASN A N    1 
ATOM   3432 C CA   . ASN A 1 228 ? -31.71799 -3.72537  31.08843  1.000 38.58834 ? 228 ASN A CA   1 
ATOM   3433 C C    . ASN A 1 228 ? -30.74488 -2.61173  30.72286  1.000 35.82081 ? 228 ASN A C    1 
ATOM   3434 O O    . ASN A 1 228 ? -30.54618 -2.31340  29.53991  1.000 37.63943 ? 228 ASN A O    1 
ATOM   3435 C CB   . ASN A 1 228 ? -33.08913 -3.15217  31.44782  1.000 40.98864 ? 228 ASN A CB   1 
ATOM   3436 C CG   . ASN A 1 228 ? -34.20208 -4.17952  31.32465  1.000 43.04699 ? 228 ASN A CG   1 
ATOM   3437 O OD1  . ASN A 1 228 ? -33.97546 -5.31808  30.91063  1.000 44.28227 ? 228 ASN A OD1  1 
ATOM   3438 N ND2  . ASN A 1 228 ? -35.41538 -3.77925  31.68744  1.000 37.85550 ? 228 ASN A ND2  1 
ATOM   3439 H H    . ASN A 1 228 ? -31.68693 -4.50418  32.90725  1.000 45.63638 ? 228 ASN A H    1 
ATOM   3440 H HA   . ASN A 1 228 ? -31.82458 -4.29131  30.30789  1.000 46.35629 ? 228 ASN A HA   1 
ATOM   3441 H HB2  . ASN A 1 228 ? -33.07040 -2.83781  32.36527  1.000 49.23666 ? 228 ASN A HB2  1 
ATOM   3442 H HB3  . ASN A 1 228 ? -33.29162 -2.41637  30.84907  1.000 49.23666 ? 228 ASN A HB3  1 
ATOM   3443 H HD21 . ASN A 1 228 ? -36.08032 -4.32230  31.63698  1.000 45.47688 ? 228 ASN A HD21 1 
ATOM   3444 H HD22 . ASN A 1 228 ? -35.53608 -2.97700  31.97282  1.000 45.47688 ? 228 ASN A HD22 1 
ATOM   3445 N N    . ASP A 1 229 ? -30.12631 -1.97948  31.71785  1.000 36.54162 ? 229 ASP A N    1 
ATOM   3446 C CA   . ASP A 1 229 ? -29.18196 -0.91011  31.40608  1.000 37.62338 ? 229 ASP A CA   1 
ATOM   3447 C C    . ASP A 1 229 ? -27.90920 -1.47156  30.78635  1.000 37.98626 ? 229 ASP A C    1 
ATOM   3448 O O    . ASP A 1 229 ? -27.39071 -0.91663  29.80933  1.000 36.40473 ? 229 ASP A O    1 
ATOM   3449 C CB   . ASP A 1 229 ? -28.89993 -0.09914  32.66717  1.000 41.01769 ? 229 ASP A CB   1 
ATOM   3450 C CG   . ASP A 1 229 ? -30.11455 0.71090   33.11508  1.000 50.79683 ? 229 ASP A CG   1 
ATOM   3451 O OD1  . ASP A 1 229 ? -30.72054 1.38013   32.24952  1.000 52.43781 ? 229 ASP A OD1  1 
ATOM   3452 O OD2  . ASP A 1 229 ? -30.48332 0.65973   34.30986  1.000 42.41803 ? 229 ASP A OD2  1 
ATOM   3453 H H    . ASP A 1 229 ? -30.23183 -2.14461  32.55523  1.000 43.90024 ? 229 ASP A H    1 
ATOM   3454 H HA   . ASP A 1 229 ? -29.56907 -0.30405  30.75514  1.000 45.19835 ? 229 ASP A HA   1 
ATOM   3455 H HB2  . ASP A 1 229 ? -28.65725 -0.70306  33.38640  1.000 49.27151 ? 229 ASP A HB2  1 
ATOM   3456 H HB3  . ASP A 1 229 ? -28.17238 0.51820   32.49261  1.000 49.27151 ? 229 ASP A HB3  1 
ATOM   3457 N N    . PHE A 1 230 ? -27.40263 -2.58234  31.31570  1.000 35.86355 ? 230 PHE A N    1 
ATOM   3458 C CA   . PHE A 1 230 ? -26.25091 -3.20885  30.68584  1.000 34.35066 ? 230 PHE A CA   1 
ATOM   3459 C C    . PHE A 1 230 ? -26.54133 -3.51510  29.22354  1.000 36.20443 ? 230 PHE A C    1 
ATOM   3460 O O    . PHE A 1 230 ? -25.75153 -3.18523  28.33115  1.000 38.77571 ? 230 PHE A O    1 
ATOM   3461 C CB   . PHE A 1 230 ? -25.86306 -4.48844  31.41570  1.000 31.55097 ? 230 PHE A CB   1 
ATOM   3462 C CG   . PHE A 1 230 ? -24.80947 -5.26579  30.70132  1.000 33.55299 ? 230 PHE A CG   1 
ATOM   3463 C CD1  . PHE A 1 230 ? -23.47455 -4.93039  30.84356  1.000 33.93238 ? 230 PHE A CD1  1 
ATOM   3464 C CD2  . PHE A 1 230 ? -25.14842 -6.30324  29.85186  1.000 35.26343 ? 230 PHE A CD2  1 
ATOM   3465 C CE1  . PHE A 1 230 ? -22.49433 -5.63195  30.17114  1.000 35.82464 ? 230 PHE A CE1  1 
ATOM   3466 C CE2  . PHE A 1 230 ? -24.17289 -7.00587  29.17581  1.000 33.61606 ? 230 PHE A CE2  1 
ATOM   3467 C CZ   . PHE A 1 230 ? -22.84370 -6.66624  29.33224  1.000 35.13767 ? 230 PHE A CZ   1 
ATOM   3468 H H    . PHE A 1 230 ? -27.69970 -2.97992  32.01804  1.000 43.08655 ? 230 PHE A H    1 
ATOM   3469 H HA   . PHE A 1 230 ? -25.50194 -2.59500  30.74171  1.000 41.27108 ? 230 PHE A HA   1 
ATOM   3470 H HB2  . PHE A 1 230 ? -25.52272 -4.25941  32.29469  1.000 37.91145 ? 230 PHE A HB2  1 
ATOM   3471 H HB3  . PHE A 1 230 ? -26.64707 -5.05330  31.50033  1.000 37.91145 ? 230 PHE A HB3  1 
ATOM   3472 H HD1  . PHE A 1 230 ? -23.23496 -4.22386  31.39882  1.000 40.76915 ? 230 PHE A HD1  1 
ATOM   3473 H HD2  . PHE A 1 230 ? -26.04296 -6.52934  29.73534  1.000 42.36641 ? 230 PHE A HD2  1 
ATOM   3474 H HE1  . PHE A 1 230 ? -21.59927 -5.40635  30.28456  1.000 43.03985 ? 230 PHE A HE1  1 
ATOM   3475 H HE2  . PHE A 1 230 ? -24.41037 -7.70839  28.61460  1.000 40.38956 ? 230 PHE A HE2  1 
ATOM   3476 H HZ   . PHE A 1 230 ? -22.18570 -7.13524  28.87183  1.000 42.21549 ? 230 PHE A HZ   1 
ATOM   3477 N N    . ASN A 1 231 ? -27.69324 -4.13347  28.96230  1.000 35.25951 ? 231 ASN A N    1 
ATOM   3478 C CA   . ASN A 1 231 ? -28.00510 -4.58417  27.61285  1.000 37.54957 ? 231 ASN A CA   1 
ATOM   3479 C C    . ASN A 1 231 ? -28.14772 -3.42444  26.64378  1.000 42.67336 ? 231 ASN A C    1 
ATOM   3480 O O    . ASN A 1 231 ? -27.84392 -3.57605  25.45556  1.000 47.20348 ? 231 ASN A O    1 
ATOM   3481 C CB   . ASN A 1 231 ? -29.27052 -5.43650  27.64743  1.000 34.53830 ? 231 ASN A CB   1 
ATOM   3482 C CG   . ASN A 1 231 ? -29.00518 -6.81170  28.21585  1.000 39.31940 ? 231 ASN A CG   1 
ATOM   3483 O OD1  . ASN A 1 231 ? -27.86937 -7.28323  28.20004  1.000 38.36114 ? 231 ASN A OD1  1 
ATOM   3484 N ND2  . ASN A 1 231 ? -30.04274 -7.46074  28.72521  1.000 35.43327 ? 231 ASN A ND2  1 
ATOM   3485 H H    . ASN A 1 231 ? -28.30379 -4.30165  29.54415  1.000 42.36170 ? 231 ASN A H    1 
ATOM   3486 H HA   . ASN A 1 231 ? -27.27915 -5.13605  27.28222  1.000 45.10977 ? 231 ASN A HA   1 
ATOM   3487 H HB2  . ASN A 1 231 ? -29.93473 -5.00047  28.20386  1.000 41.49625 ? 231 ASN A HB2  1 
ATOM   3488 H HB3  . ASN A 1 231 ? -29.61057 -5.54092  26.74501  1.000 41.49625 ? 231 ASN A HB3  1 
ATOM   3489 H HD21 . ASN A 1 231 ? -29.93684 -8.24609  29.05929  1.000 42.57021 ? 231 ASN A HD21 1 
ATOM   3490 H HD22 . ASN A 1 231 ? -30.82177 -7.09646  28.72159  1.000 42.57021 ? 231 ASN A HD22 1 
ATOM   3491 N N    . LEU A 1 232 ? -28.59115 -2.26113  27.11603  1.000 39.01924 ? 232 LEU A N    1 
ATOM   3492 C CA   . LEU A 1 232 ? -28.57663 -1.09666  26.24020  1.000 43.96144 ? 232 LEU A CA   1 
ATOM   3493 C C    . LEU A 1 232 ? -27.17686 -0.85843  25.69265  1.000 42.91694 ? 232 LEU A C    1 
ATOM   3494 O O    . LEU A 1 232 ? -27.02348 -0.39829  24.55641  1.000 45.04496 ? 232 LEU A O    1 
ATOM   3495 C CB   . LEU A 1 232 ? -29.08062 0.13473   26.97948  1.000 43.88351 ? 232 LEU A CB   1 
ATOM   3496 C CG   . LEU A 1 232 ? -30.57536 0.08281   27.29841  1.000 47.21470 ? 232 LEU A CG   1 
ATOM   3497 C CD1  . LEU A 1 232 ? -30.96298 1.22866   28.22352  1.000 50.12148 ? 232 LEU A CD1  1 
ATOM   3498 C CD2  . LEU A 1 232 ? -31.40428 0.10533   26.01461  1.000 43.88935 ? 232 LEU A CD2  1 
ATOM   3499 H H    . LEU A 1 232 ? -28.89383 -2.12558  27.90951  1.000 46.87337 ? 232 LEU A H    1 
ATOM   3500 H HA   . LEU A 1 232 ? -29.17976 -1.24864  25.49586  1.000 52.80401 ? 232 LEU A HA   1 
ATOM   3501 H HB2  . LEU A 1 232 ? -28.59939 0.21459   27.81789  1.000 52.71050 ? 232 LEU A HB2  1 
ATOM   3502 H HB3  . LEU A 1 232 ? -28.92014 0.91713   26.42902  1.000 52.71050 ? 232 LEU A HB3  1 
ATOM   3503 H HG   . LEU A 1 232 ? -30.77286 -0.74827  27.75798  1.000 56.70793 ? 232 LEU A HG   1 
ATOM   3504 H HD11 . LEU A 1 232 ? -31.92418 1.21833   28.35343  1.000 60.19607 ? 232 LEU A HD11 1 
ATOM   3505 H HD12 . LEU A 1 232 ? -30.51286 1.11321   29.07497  1.000 60.19607 ? 232 LEU A HD12 1 
ATOM   3506 H HD13 . LEU A 1 232 ? -30.69304 2.06732   27.81770  1.000 60.19607 ? 232 LEU A HD13 1 
ATOM   3507 H HD21 . LEU A 1 232 ? -31.11915 0.85398   25.46769  1.000 52.71750 ? 232 LEU A HD21 1 
ATOM   3508 H HD22 . LEU A 1 232 ? -31.26613 -0.72634  25.53487  1.000 52.71750 ? 232 LEU A HD22 1 
ATOM   3509 H HD23 . LEU A 1 232 ? -32.34141 0.20230   26.24544  1.000 52.71750 ? 232 LEU A HD23 1 
ATOM   3510 N N    . VAL A 1 233 ? -26.15215 -1.18518  26.47212  1.000 41.37826 ? 233 VAL A N    1 
ATOM   3511 C CA   . VAL A 1 233 ? -24.78825 -1.09930  25.96975  1.000 47.21739 ? 233 VAL A CA   1 
ATOM   3512 C C    . VAL A 1 233 ? -24.35775 -2.38004  25.25476  1.000 41.94861 ? 233 VAL A C    1 
ATOM   3513 O O    . VAL A 1 233 ? -23.49697 -2.33455  24.37606  1.000 43.42854 ? 233 VAL A O    1 
ATOM   3514 C CB   . VAL A 1 233 ? -23.82641 -0.74395  27.11246  1.000 57.17885 ? 233 VAL A CB   1 
ATOM   3515 C CG1  . VAL A 1 233 ? -22.40836 -0.53336  26.57871  1.000 58.76958 ? 233 VAL A CG1  1 
ATOM   3516 C CG2  . VAL A 1 233 ? -24.33031 0.49977   27.84509  1.000 51.92736 ? 233 VAL A CG2  1 
ATOM   3517 H H    . VAL A 1 233 ? -26.21923 -1.45615  27.28555  1.000 49.70421 ? 233 VAL A H    1 
ATOM   3518 H HA   . VAL A 1 233 ? -24.74429 -0.38521  25.31475  1.000 56.71116 ? 233 VAL A HA   1 
ATOM   3519 H HB   . VAL A 1 233 ? -23.79230 -1.47817  27.74544  1.000 68.66491 ? 233 VAL A HB   1 
ATOM   3520 H HG11 . VAL A 1 233 ? -21.87160 -0.10982  27.26675  1.000 70.57378 ? 233 VAL A HG11 1 
ATOM   3521 H HG12 . VAL A 1 233 ? -22.02761 -1.39447  26.34542  1.000 70.57378 ? 233 VAL A HG12 1 
ATOM   3522 H HG13 . VAL A 1 233 ? -22.44763 0.03463   25.79338  1.000 70.57378 ? 233 VAL A HG13 1 
ATOM   3523 H HG21 . VAL A 1 233 ? -23.63858 0.81256   28.44890  1.000 62.36313 ? 233 VAL A HG21 1 
ATOM   3524 H HG22 . VAL A 1 233 ? -24.53672 1.18813   27.19359  1.000 62.36313 ? 233 VAL A HG22 1 
ATOM   3525 H HG23 . VAL A 1 233 ? -25.12787 0.26932   28.34678  1.000 62.36313 ? 233 VAL A HG23 1 
ATOM   3526 N N    . ALA A 1 234 ? -24.94294 -3.53317  25.59637  1.000 43.50057 ? 234 ALA A N    1 
ATOM   3527 C CA   . ALA A 1 234 ? -24.64598 -4.73475  24.82655  1.000 41.61673 ? 234 ALA A CA   1 
ATOM   3528 C C    . ALA A 1 234 ? -25.05313 -4.55176  23.37112  1.000 42.92544 ? 234 ALA A C    1 
ATOM   3529 O O    . ALA A 1 234 ? -24.29767 -4.89843  22.45527  1.000 42.51054 ? 234 ALA A O    1 
ATOM   3530 C CB   . ALA A 1 234 ? -25.35056 -5.94902  25.42480  1.000 41.31306 ? 234 ALA A CB   1 
ATOM   3531 H H    . ALA A 1 234 ? -25.49536 -3.63891  26.24695  1.000 52.25097 ? 234 ALA A H    1 
ATOM   3532 H HA   . ALA A 1 234 ? -23.69137 -4.90181  24.86769  1.000 49.99037 ? 234 ALA A HA   1 
ATOM   3533 H HB1  . ALA A 1 234 ? -25.09627 -6.74005  24.92429  1.000 49.62597 ? 234 ALA A HB1  1 
ATOM   3534 H HB2  . ALA A 1 234 ? -25.08295 -6.04423  26.35228  1.000 49.62597 ? 234 ALA A HB2  1 
ATOM   3535 H HB3  . ALA A 1 234 ? -26.30987 -5.81664  25.36925  1.000 49.62597 ? 234 ALA A HB3  1 
ATOM   3536 N N    . MET A 1 235 ? -26.24086 -3.99251  23.13972  1.000 43.82275 ? 235 MET A N    1 
ATOM   3537 C CA   . MET A 1 235 ? -26.73795 -3.84734  21.77554  1.000 42.11841 ? 235 MET A CA   1 
ATOM   3538 C C    . MET A 1 235 ? -25.76718 -3.03725  20.92743  1.000 40.50525 ? 235 MET A C    1 
ATOM   3539 O O    . MET A 1 235 ? -25.40851 -3.43737  19.81668  1.000 42.75973 ? 235 MET A O    1 
ATOM   3540 C CB   . MET A 1 235 ? -28.11794 -3.19282  21.78565  1.000 43.75533 ? 235 MET A CB   1 
ATOM   3541 H H    . MET A 1 235 ? -26.77065 -3.69319  23.74744  1.000 52.63759 ? 235 MET A H    1 
ATOM   3542 H HA   . MET A 1 235 ? -26.83355 -4.73096  21.38698  1.000 50.59238 ? 235 MET A HA   1 
ATOM   3543 N N    . LYS A 1 236 ? -25.32080 -1.89118  21.44833  1.000 43.41442 ? 236 LYS A N    1 
ATOM   3544 C CA   . LYS A 1 236 ? -24.44529 -1.01662  20.67397  1.000 41.64501 ? 236 LYS A CA   1 
ATOM   3545 C C    . LYS A 1 236 ? -23.20303 -1.75757  20.19538  1.000 40.51112 ? 236 LYS A C    1 
ATOM   3546 O O    . LYS A 1 236 ? -22.70097 -1.49748  19.09621  1.000 39.66421 ? 236 LYS A O    1 
ATOM   3547 C CB   . LYS A 1 236 ? -24.05639 0.19598   21.51877  1.000 46.07842 ? 236 LYS A CB   1 
ATOM   3548 C CG   . LYS A 1 236 ? -23.09829 1.18349   20.85165  1.000 48.84408 ? 236 LYS A CG   1 
ATOM   3549 C CD   . LYS A 1 236 ? -22.74779 2.33536   21.81040  1.000 58.14465 ? 236 LYS A CD   1 
ATOM   3550 C CE   . LYS A 1 236 ? -21.38626 2.97594   21.51028  1.000 51.94837 ? 236 LYS A CE   1 
ATOM   3551 N NZ   . LYS A 1 236 ? -21.45134 4.16097   20.59033  1.000 48.63690 ? 236 LYS A NZ   1 
ATOM   3552 H H    . LYS A 1 236 ? -25.50828 -1.60262  22.23648  1.000 52.14759 ? 236 LYS A H    1 
ATOM   3553 H HA   . LYS A 1 236 ? -24.92310 -0.70352  19.89002  1.000 50.02430 ? 236 LYS A HA   1 
ATOM   3554 H HB2  . LYS A 1 236 ? -24.86445 0.68391   21.74206  1.000 55.34440 ? 236 LYS A HB2  1 
ATOM   3555 H HB3  . LYS A 1 236 ? -23.62622 -0.12152  22.32812  1.000 55.34440 ? 236 LYS A HB3  1 
ATOM   3556 H HG2  . LYS A 1 236 ? -22.27872 0.72553   20.60776  1.000 58.66319 ? 236 LYS A HG2  1 
ATOM   3557 H HG3  . LYS A 1 236 ? -23.51722 1.55764   20.06082  1.000 58.66319 ? 236 LYS A HG3  1 
ATOM   3558 H HD2  . LYS A 1 236 ? -23.42505 3.02562   21.73454  1.000 69.82387 ? 236 LYS A HD2  1 
ATOM   3559 H HD3  . LYS A 1 236 ? -22.72271 1.99348   22.71781  1.000 69.82387 ? 236 LYS A HD3  1 
ATOM   3560 H HE2  . LYS A 1 236 ? -20.99254 3.27403   22.34516  1.000 62.38833 ? 236 LYS A HE2  1 
ATOM   3561 H HE3  . LYS A 1 236 ? -20.81577 2.31165   21.09297  1.000 62.38833 ? 236 LYS A HE3  1 
ATOM   3562 H HZ1  . LYS A 1 236 ? -21.98074 4.78677   20.93705  1.000 58.41457 ? 236 LYS A HZ1  1 
ATOM   3563 H HZ2  . LYS A 1 236 ? -20.63745 4.50229   20.47557  1.000 58.41457 ? 236 LYS A HZ2  1 
ATOM   3564 H HZ3  . LYS A 1 236 ? -21.77542 3.91451   19.79892  1.000 58.41457 ? 236 LYS A HZ3  1 
ATOM   3565 N N    . TYR A 1 237 ? -22.69017 -2.67565  21.00403  1.000 40.91026 ? 237 TYR A N    1 
ATOM   3566 C CA   . TYR A 1 237 ? -21.44158 -3.36436  20.70869  1.000 39.98084 ? 237 TYR A CA   1 
ATOM   3567 C C    . TYR A 1 237 ? -21.67094 -4.74457  20.11442  1.000 38.28285 ? 237 TYR A C    1 
ATOM   3568 O O    . TYR A 1 237 ? -20.72216 -5.52449  19.98009  1.000 38.08232 ? 237 TYR A O    1 
ATOM   3569 C CB   . TYR A 1 237 ? -20.59556 -3.42601  21.97821  1.000 41.47072 ? 237 TYR A CB   1 
ATOM   3570 C CG   . TYR A 1 237 ? -20.03081 -2.06735  22.34840  1.000 40.76277 ? 237 TYR A CG   1 
ATOM   3571 C CD1  . TYR A 1 237 ? -18.79246 -1.65711  21.86889  1.000 41.95015 ? 237 TYR A CD1  1 
ATOM   3572 C CD2  . TYR A 1 237 ? -20.74575 -1.18401  23.14958  1.000 42.05888 ? 237 TYR A CD2  1 
ATOM   3573 C CE1  . TYR A 1 237 ? -18.27300 -0.41201  22.19143  1.000 43.03711 ? 237 TYR A CE1  1 
ATOM   3574 C CE2  . TYR A 1 237 ? -20.23528 0.06287   23.47762  1.000 42.53963 ? 237 TYR A CE2  1 
ATOM   3575 C CZ   . TYR A 1 237 ? -19.00038 0.44423   22.99729  1.000 43.86993 ? 237 TYR A CZ   1 
ATOM   3576 O OH   . TYR A 1 237 ? -18.50155 1.68566   23.32713  1.000 43.06296 ? 237 TYR A OH   1 
ATOM   3577 H H    . TYR A 1 237 ? -23.05396 -2.92132  21.74356  1.000 49.14260 ? 237 TYR A H    1 
ATOM   3578 H HA   . TYR A 1 237 ? -20.93404 -2.86600  20.04919  1.000 48.02730 ? 237 TYR A HA   1 
ATOM   3579 H HB2  . TYR A 1 237 ? -21.14620 -3.73696  22.71374  1.000 49.81515 ? 237 TYR A HB2  1 
ATOM   3580 H HB3  . TYR A 1 237 ? -19.85406 -4.03549  21.83815  1.000 49.81515 ? 237 TYR A HB3  1 
ATOM   3581 H HD1  . TYR A 1 237 ? -18.30304 -2.22797  21.32164  1.000 50.39047 ? 237 TYR A HD1  1 
ATOM   3582 H HD2  . TYR A 1 237 ? -21.58172 -1.43403  23.47138  1.000 50.52094 ? 237 TYR A HD2  1 
ATOM   3583 H HE1  . TYR A 1 237 ? -17.44013 -0.15462  21.86743  1.000 51.69482 ? 237 TYR A HE1  1 
ATOM   3584 H HE2  . TYR A 1 237 ? -20.72390 0.63958   24.01944  1.000 51.09785 ? 237 TYR A HE2  1 
ATOM   3585 H HH   . TYR A 1 237 ? -19.11082 2.16242   23.65439  1.000 51.72584 ? 237 TYR A HH   1 
ATOM   3586 N N    . ASN A 1 238 ? -22.91086 -5.03743  19.71834  1.000 35.95347 ? 238 ASN A N    1 
ATOM   3587 C CA   . ASN A 1 238 ? -23.28729 -6.32872  19.14758  1.000 34.52026 ? 238 ASN A CA   1 
ATOM   3588 C C    . ASN A 1 238 ? -22.94456 -7.47103  20.09749  1.000 35.42232 ? 238 ASN A C    1 
ATOM   3589 O O    . ASN A 1 238 ? -22.44303 -8.51847  19.68472  1.000 32.98762 ? 238 ASN A O    1 
ATOM   3590 C CB   . ASN A 1 238 ? -22.64940 -6.52956  17.77324  1.000 34.54793 ? 238 ASN A CB   1 
ATOM   3591 C CG   . ASN A 1 238 ? -23.25223 -5.61392  16.72174  1.000 37.97357 ? 238 ASN A CG   1 
ATOM   3592 O OD1  . ASN A 1 238 ? -24.44019 -5.29393  16.77282  1.000 39.97799 ? 238 ASN A OD1  1 
ATOM   3593 N ND2  . ASN A 1 238 ? -22.43625 -5.18320  15.76784  1.000 37.33087 ? 238 ASN A ND2  1 
ATOM   3594 H H    . ASN A 1 238 ? -23.57008 -4.48775  19.77205  1.000 43.19446 ? 238 ASN A H    1 
ATOM   3595 H HA   . ASN A 1 238 ? -24.24933 -6.34462  19.02458  1.000 41.47461 ? 238 ASN A HA   1 
ATOM   3596 H HB2  . ASN A 1 238 ? -21.70016 -6.33877  17.83196  1.000 41.50781 ? 238 ASN A HB2  1 
ATOM   3597 H HB3  . ASN A 1 238 ? -22.78648 -7.44701  17.48970  1.000 41.50781 ? 238 ASN A HB3  1 
ATOM   3598 H HD21 . ASN A 1 238 ? -22.73291 -4.66268  15.15087  1.000 44.84733 ? 238 ASN A HD21 1 
ATOM   3599 H HD22 . ASN A 1 238 ? -21.61083 -5.42460  15.76667  1.000 44.84733 ? 238 ASN A HD22 1 
ATOM   3600 N N    . TYR A 1 239 ? -23.23721 -7.26578  21.37666  1.000 32.36474 ? 239 TYR A N    1 
ATOM   3601 C CA   . TYR A 1 239 ? -23.22254 -8.33352  22.36021  1.000 33.23646 ? 239 TYR A CA   1 
ATOM   3602 C C    . TYR A 1 239 ? -24.60605 -8.96568  22.50228  1.000 33.19801 ? 239 TYR A C    1 
ATOM   3603 O O    . TYR A 1 239 ? -25.63842 -8.30159  22.37067  1.000 31.72018 ? 239 TYR A O    1 
ATOM   3604 C CB   . TYR A 1 239 ? -22.76297 -7.80054  23.72050  1.000 29.80743 ? 239 TYR A CB   1 
ATOM   3605 C CG   . TYR A 1 239 ? -21.26437 -7.81304  23.93759  1.000 30.53447 ? 239 TYR A CG   1 
ATOM   3606 C CD1  . TYR A 1 239 ? -20.39036 -7.19676  23.04556  1.000 30.93365 ? 239 TYR A CD1  1 
ATOM   3607 C CD2  . TYR A 1 239 ? -20.72097 -8.42476  25.05554  1.000 28.76052 ? 239 TYR A CD2  1 
ATOM   3608 C CE1  . TYR A 1 239 ? -19.00799 -7.21096  23.26459  1.000 31.51990 ? 239 TYR A CE1  1 
ATOM   3609 C CE2  . TYR A 1 239 ? -19.35549 -8.44176  25.28236  1.000 28.94088 ? 239 TYR A CE2  1 
ATOM   3610 C CZ   . TYR A 1 239 ? -18.49828 -7.83625  24.39072  1.000 29.84125 ? 239 TYR A CZ   1 
ATOM   3611 O OH   . TYR A 1 239 ? -17.13948 -7.86577  24.64120  1.000 29.28459 ? 239 TYR A OH   1 
ATOM   3612 H H    . TYR A 1 239 ? -23.45156 -6.49977  21.70358  1.000 38.88797 ? 239 TYR A H    1 
ATOM   3613 H HA   . TYR A 1 239 ? -22.60480 -9.02269  22.06981  1.000 39.93404 ? 239 TYR A HA   1 
ATOM   3614 H HB2  . TYR A 1 239 ? -23.06206 -6.88193  23.80763  1.000 35.81920 ? 239 TYR A HB2  1 
ATOM   3615 H HB3  . TYR A 1 239 ? -23.16233 -8.34682  24.41547  1.000 35.81920 ? 239 TYR A HB3  1 
ATOM   3616 H HD1  . TYR A 1 239 ? -20.73036 -6.76926  22.29288  1.000 37.17067 ? 239 TYR A HD1  1 
ATOM   3617 H HD2  . TYR A 1 239 ? -21.28764 -8.83415  25.66888  1.000 34.56291 ? 239 TYR A HD2  1 
ATOM   3618 H HE1  . TYR A 1 239 ? -18.43444 -6.80257  22.65701  1.000 37.87418 ? 239 TYR A HE1  1 
ATOM   3619 H HE2  . TYR A 1 239 ? -19.01617 -8.86315  26.03879  1.000 34.77934 ? 239 TYR A HE2  1 
ATOM   3620 H HH   . TYR A 1 239 ? -16.99987 -7.86133  25.46950  1.000 35.19179 ? 239 TYR A HH   1 
ATOM   3621 N N    . GLU A 1 240 ? -24.61003 -10.26901 22.77639  1.000 30.44980 ? 240 GLU A N    1 
ATOM   3622 C CA   . GLU A 1 240 ? -25.85737 -10.95105 23.06806  1.000 33.49893 ? 240 GLU A CA   1 
ATOM   3623 C C    . GLU A 1 240 ? -26.50630 -10.32811 24.30090  1.000 34.00160 ? 240 GLU A C    1 
ATOM   3624 O O    . GLU A 1 240 ? -25.81110 -9.98657  25.26592  1.000 29.11724 ? 240 GLU A O    1 
ATOM   3625 C CB   . GLU A 1 240 ? -25.64060 -12.43656 23.34018  1.000 35.31283 ? 240 GLU A CB   1 
ATOM   3626 C CG   . GLU A 1 240 ? -25.24306 -13.28168 22.16701  1.000 39.56425 ? 240 GLU A CG   1 
ATOM   3627 C CD   . GLU A 1 240 ? -25.29005 -14.75444 22.52168  1.000 45.70837 ? 240 GLU A CD   1 
ATOM   3628 O OE1  . GLU A 1 240 ? -25.10933 -15.08026 23.71773  1.000 42.46268 ? 240 GLU A OE1  1 
ATOM   3629 O OE2  . GLU A 1 240 ? -25.52816 -15.57873 21.61337  1.000 60.53441 ? 240 GLU A OE2  1 
ATOM   3630 H H    . GLU A 1 240 ? -23.91185 -10.77065 22.79861  1.000 36.59005 ? 240 GLU A H    1 
ATOM   3631 H HA   . GLU A 1 240 ? -26.44037 -10.86124 22.29802  1.000 40.24901 ? 240 GLU A HA   1 
ATOM   3632 H HB2  . GLU A 1 240 ? -24.93744 -12.52162 24.00293  1.000 42.42568 ? 240 GLU A HB2  1 
ATOM   3633 H HB3  . GLU A 1 240 ? -26.46916 -12.80307 23.68666  1.000 42.42568 ? 240 GLU A HB3  1 
ATOM   3634 H HG2  . GLU A 1 240 ? -25.85523 -13.12243 21.43163  1.000 47.52740 ? 240 GLU A HG2  1 
ATOM   3635 H HG3  . GLU A 1 240 ? -24.33787 -13.05816 21.89950  1.000 47.52740 ? 240 GLU A HG3  1 
ATOM   3636 N N    . PRO A 1 241 ? -27.82442 -10.19208 24.31920  1.000 32.79944 ? 241 PRO A N    1 
ATOM   3637 C CA   . PRO A 1 241 ? -28.48649 -9.71461  25.53746  1.000 33.72167 ? 241 PRO A CA   1 
ATOM   3638 C C    . PRO A 1 241 ? -28.27436 -10.70184 26.67666  1.000 35.46963 ? 241 PRO A C    1 
ATOM   3639 O O    . PRO A 1 241 ? -28.36056 -11.91775 26.49575  1.000 33.97987 ? 241 PRO A O    1 
ATOM   3640 C CB   . PRO A 1 241 ? -29.95758 -9.61408  25.12723  1.000 33.87059 ? 241 PRO A CB   1 
ATOM   3641 C CG   . PRO A 1 241 ? -29.93475 -9.52399  23.63645  1.000 38.37389 ? 241 PRO A CG   1 
ATOM   3642 C CD   . PRO A 1 241 ? -28.77646 -10.37337 23.21041  1.000 37.89476 ? 241 PRO A CD   1 
ATOM   3643 H HA   . PRO A 1 241 ? -28.16872 -8.83546  25.79632  1.000 40.51629 ? 241 PRO A HA   1 
ATOM   3644 H HB2  . PRO A 1 241 ? -30.43732 -10.40454 25.42035  1.000 40.69500 ? 241 PRO A HB2  1 
ATOM   3645 H HB3  . PRO A 1 241 ? -30.35611 -8.82043  25.51733  1.000 40.69500 ? 241 PRO A HB3  1 
ATOM   3646 H HG2  . PRO A 1 241 ? -30.76657 -9.86528  23.27246  1.000 46.09896 ? 241 PRO A HG2  1 
ATOM   3647 H HG3  . PRO A 1 241 ? -29.80672 -8.60203  23.36350  1.000 46.09896 ? 241 PRO A HG3  1 
ATOM   3648 H HD2  . PRO A 1 241 ? -29.03908 -11.30326 23.12527  1.000 45.52400 ? 241 PRO A HD2  1 
ATOM   3649 H HD3  . PRO A 1 241 ? -28.40132 -10.05665 22.37384  1.000 45.52400 ? 241 PRO A HD3  1 
ATOM   3650 N N    . LEU A 1 242 ? -27.97787 -10.16322 27.85490  1.000 32.09113 ? 242 LEU A N    1 
ATOM   3651 C CA   . LEU A 1 242 ? -27.79449 -10.98195 29.04522  1.000 32.64663 ? 242 LEU A CA   1 
ATOM   3652 C C    . LEU A 1 242 ? -29.12753 -11.19593 29.75518  1.000 35.10402 ? 242 LEU A C    1 
ATOM   3653 O O    . LEU A 1 242 ? -29.92007 -10.26277 29.91757  1.000 34.07969 ? 242 LEU A O    1 
ATOM   3654 C CB   . LEU A 1 242 ? -26.79144 -10.33242 29.99904  1.000 33.71345 ? 242 LEU A CB   1 
ATOM   3655 C CG   . LEU A 1 242 ? -26.27423 -11.24929 31.11034  1.000 34.74826 ? 242 LEU A CG   1 
ATOM   3656 C CD1  . LEU A 1 242 ? -25.20015 -12.22322 30.60339  1.000 33.50485 ? 242 LEU A CD1  1 
ATOM   3657 C CD2  . LEU A 1 242 ? -25.74419 -10.42934 32.26461  1.000 37.27918 ? 242 LEU A CD2  1 
ATOM   3658 H H    . LEU A 1 242 ? -27.87719 -9.31995  27.99037  1.000 38.55965 ? 242 LEU A H    1 
ATOM   3659 H HA   . LEU A 1 242 ? -27.44715 -11.84962 28.78560  1.000 39.22624 ? 242 LEU A HA   1 
ATOM   3660 H HB2  . LEU A 1 242 ? -26.02472 -10.03694 29.48355  1.000 40.50643 ? 242 LEU A HB2  1 
ATOM   3661 H HB3  . LEU A 1 242 ? -27.21914 -9.57202  30.42302  1.000 40.50643 ? 242 LEU A HB3  1 
ATOM   3662 H HG   . LEU A 1 242 ? -27.01729 -11.78764 31.42489  1.000 41.74820 ? 242 LEU A HG   1 
ATOM   3663 H HD11 . LEU A 1 242 ? -24.81048 -12.68615 31.36152  1.000 40.25612 ? 242 LEU A HD11 1 
ATOM   3664 H HD12 . LEU A 1 242 ? -25.61236 -12.86262 30.00160  1.000 40.25612 ? 242 LEU A HD12 1 
ATOM   3665 H HD13 . LEU A 1 242 ? -24.51509 -11.72162 30.13435  1.000 40.25612 ? 242 LEU A HD13 1 
ATOM   3666 H HD21 . LEU A 1 242 ? -25.38011 -11.02742 32.93591  1.000 44.78531 ? 242 LEU A HD21 1 
ATOM   3667 H HD22 . LEU A 1 242 ? -25.04938 -9.83647  31.93803  1.000 44.78531 ? 242 LEU A HD22 1 
ATOM   3668 H HD23 . LEU A 1 242 ? -26.47091 -9.91029  32.64324  1.000 44.78531 ? 242 LEU A HD23 1 
ATOM   3669 N N    . THR A 1 243 ? -29.35270 -12.43308 30.19426  1.000 33.79815 ? 243 THR A N    1 
ATOM   3670 C CA   . THR A 1 243 ? -30.59606 -12.88071 30.79948  1.000 32.54168 ? 243 THR A CA   1 
ATOM   3671 C C    . THR A 1 243 ? -30.32901 -13.41582 32.19999  1.000 33.40531 ? 243 THR A C    1 
ATOM   3672 O O    . THR A 1 243 ? -29.19090 -13.71230 32.56523  1.000 33.93458 ? 243 THR A O    1 
ATOM   3673 C CB   . THR A 1 243 ? -31.23133 -13.99423 29.96917  1.000 32.16566 ? 243 THR A CB   1 
ATOM   3674 O OG1  . THR A 1 243 ? -30.50076 -15.20406 30.21200  1.000 33.16682 ? 243 THR A OG1  1 
ATOM   3675 C CG2  . THR A 1 243 ? -31.15645 -13.65492 28.50229  1.000 34.74800 ? 243 THR A CG2  1 
ATOM   3676 H H    . THR A 1 243 ? -28.76659 -13.06071 30.14797  1.000 40.60806 ? 243 THR A H    1 
ATOM   3677 H HA   . THR A 1 243 ? -31.20407 -12.12698 30.85540  1.000 39.10030 ? 243 THR A HA   1 
ATOM   3678 H HB   . THR A 1 243 ? -32.16448 -14.10921 30.20772  1.000 38.64909 ? 243 THR A HB   1 
ATOM   3679 H HG1  . THR A 1 243 ? -30.71960 -15.52747 30.95572  1.000 39.85047 ? 243 THR A HG1  1 
ATOM   3680 H HG21 . THR A 1 243 ? -30.24869 -13.77117 28.18080  1.000 41.74789 ? 243 THR A HG21 1 
ATOM   3681 H HG22 . THR A 1 243 ? -31.74624 -14.23593 27.99685  1.000 41.74789 ? 243 THR A HG22 1 
ATOM   3682 H HG23 . THR A 1 243 ? -31.42498 -12.73364 28.36075  1.000 41.74789 ? 243 THR A HG23 1 
ATOM   3683 N N    . GLN A 1 244 ? -31.39694 -13.58811 32.97600  1.000 31.99826 ? 244 GLN A N    1 
ATOM   3684 C CA   . GLN A 1 244 ? -31.21861 -14.11214 34.32838  1.000 32.36865 ? 244 GLN A CA   1 
ATOM   3685 C C    . GLN A 1 244 ? -30.66360 -15.53829 34.31490  1.000 31.59849 ? 244 GLN A C    1 
ATOM   3686 O O    . GLN A 1 244 ? -29.91940 -15.91333 35.22512  1.000 34.64151 ? 244 GLN A O    1 
ATOM   3687 C CB   . GLN A 1 244 ? -32.53673 -14.03243 35.10097  1.000 34.43684 ? 244 GLN A CB   1 
ATOM   3688 C CG   . GLN A 1 244 ? -32.44926 -14.47015 36.56722  1.000 34.68834 ? 244 GLN A CG   1 
ATOM   3689 C CD   . GLN A 1 244 ? -31.51890 -13.60910 37.41431  1.000 34.18913 ? 244 GLN A CD   1 
ATOM   3690 O OE1  . GLN A 1 244 ? -31.50282 -12.37996 37.30264  1.000 33.53801 ? 244 GLN A OE1  1 
ATOM   3691 N NE2  . GLN A 1 244 ? -30.73647 -14.26014 38.27121  1.000 33.55499 ? 244 GLN A NE2  1 
ATOM   3692 H H    . GLN A 1 244 ? -32.20912 -13.41545 32.75205  1.000 38.44820 ? 244 GLN A H    1 
ATOM   3693 H HA   . GLN A 1 244 ? -30.57510 -13.55992 34.79938  1.000 38.89267 ? 244 GLN A HA   1 
ATOM   3694 H HB2  . GLN A 1 244 ? -32.84554 -13.11298 35.08886  1.000 41.37449 ? 244 GLN A HB2  1 
ATOM   3695 H HB3  . GLN A 1 244 ? -33.18519 -14.60598 34.66342  1.000 41.37449 ? 244 GLN A HB3  1 
ATOM   3696 H HG2  . GLN A 1 244 ? -33.33482 -14.42238 36.96015  1.000 41.67630 ? 244 GLN A HG2  1 
ATOM   3697 H HG3  . GLN A 1 244 ? -32.11997 -15.38191 36.60123  1.000 41.67630 ? 244 GLN A HG3  1 
ATOM   3698 H HE21 . GLN A 1 244 ? -30.77501 -15.11774 38.32249  1.000 40.31628 ? 244 GLN A HE21 1 
ATOM   3699 H HE22 . GLN A 1 244 ? -30.19221 -13.82333 38.77378  1.000 40.31628 ? 244 GLN A HE22 1 
ATOM   3700 N N    . ASP A 1 245 ? -30.99515 -16.34972 33.30203  1.000 34.73741 ? 245 ASP A N    1 
ATOM   3701 C CA   . ASP A 1 245 ? -30.38892 -17.67904 33.21996  1.000 35.85506 ? 245 ASP A CA   1 
ATOM   3702 C C    . ASP A 1 245 ? -28.87052 -17.57937 33.10468  1.000 32.90406 ? 245 ASP A C    1 
ATOM   3703 O O    . ASP A 1 245 ? -28.13421 -18.36337 33.71374  1.000 34.74392 ? 245 ASP A O    1 
ATOM   3704 C CB   . ASP A 1 245 ? -30.95009 -18.45579 32.03122  1.000 38.26023 ? 245 ASP A CB   1 
ATOM   3705 C CG   . ASP A 1 245 ? -32.42659 -18.74799 32.16679  1.000 46.69262 ? 245 ASP A CG   1 
ATOM   3706 O OD1  . ASP A 1 245 ? -32.88102 -19.05325 33.29182  1.000 37.66422 ? 245 ASP A OD1  1 
ATOM   3707 O OD2  . ASP A 1 245 ? -33.12871 -18.66941 31.13595  1.000 56.22293 ? 245 ASP A OD2  1 
ATOM   3708 H H    . ASP A 1 245 ? -31.54927 -16.15944 32.67247  1.000 41.73518 ? 245 ASP A H    1 
ATOM   3709 H HA   . ASP A 1 245 ? -30.61207 -18.16655 34.02832  1.000 43.07637 ? 245 ASP A HA   1 
ATOM   3710 H HB2  . ASP A 1 245 ? -30.82067 -17.93432 31.22362  1.000 45.96256 ? 245 ASP A HB2  1 
ATOM   3711 H HB3  . ASP A 1 245 ? -30.48248 -19.30246 31.95794  1.000 45.96256 ? 245 ASP A HB3  1 
ATOM   3712 N N    . HIS A 1 246 ? -28.38872 -16.62616 32.30049  1.000 34.62091 ? 246 HIS A N    1 
ATOM   3713 C CA   . HIS A 1 246 ? -26.96326 -16.33268 32.25880  1.000 32.94547 ? 246 HIS A CA   1 
ATOM   3714 C C    . HIS A 1 246 ? -26.44375 -15.96957 33.64890  1.000 30.48059 ? 246 HIS A C    1 
ATOM   3715 O O    . HIS A 1 246 ? -25.41620 -16.49026 34.10052  1.000 30.27091 ? 246 HIS A O    1 
ATOM   3716 C CB   . HIS A 1 246 ? -26.69251 -15.18152 31.28748  1.000 31.58266 ? 246 HIS A CB   1 
ATOM   3717 C CG   . HIS A 1 246 ? -26.98423 -15.49651 29.85095  1.000 32.28824 ? 246 HIS A CG   1 
ATOM   3718 N ND1  . HIS A 1 246 ? -27.37500 -14.52698 28.95195  1.000 34.70743 ? 246 HIS A ND1  1 
ATOM   3719 C CD2  . HIS A 1 246 ? -26.90536 -16.65101 29.14839  1.000 35.10796 ? 246 HIS A CD2  1 
ATOM   3720 C CE1  . HIS A 1 246 ? -27.54236 -15.07420 27.76166  1.000 33.76865 ? 246 HIS A CE1  1 
ATOM   3721 N NE2  . HIS A 1 246 ? -27.26768 -16.36314 27.85350  1.000 34.64298 ? 246 HIS A NE2  1 
ATOM   3722 H H    . HIS A 1 246 ? -28.86605 -16.14105 31.77473  1.000 41.59538 ? 246 HIS A H    1 
ATOM   3723 H HA   . HIS A 1 246 ? -26.49316 -17.12031 31.94328  1.000 39.58485 ? 246 HIS A HA   1 
ATOM   3724 H HB2  . HIS A 1 246 ? -27.24759 -14.42726 31.54021  1.000 37.94948 ? 246 HIS A HB2  1 
ATOM   3725 H HB3  . HIS A 1 246 ? -25.75530 -14.93922 31.34943  1.000 37.94948 ? 246 HIS A HB3  1 
ATOM   3726 H HD2  . HIS A 1 246 ? -26.65340 -17.48278 29.47942  1.000 42.17984 ? 246 HIS A HD2  1 
ATOM   3727 H HE1  . HIS A 1 246 ? -27.80830 -14.62811 26.99018  1.000 40.57267 ? 246 HIS A HE1  1 
ATOM   3728 H HE2  . HIS A 1 246 ? -27.30879 -16.93014 27.20819  1.000 41.62187 ? 246 HIS A HE2  1 
ATOM   3729 N N    . VAL A 1 247 ? -27.13879 -15.06011 34.33235  1.000 29.72057 ? 247 VAL A N    1 
ATOM   3730 C CA   . VAL A 1 247 ? -26.77337 -14.69188 35.69906  1.000 29.42101 ? 247 VAL A CA   1 
ATOM   3731 C C    . VAL A 1 247 ? -26.65980 -15.93395 36.58686  1.000 29.52754 ? 247 VAL A C    1 
ATOM   3732 O O    . VAL A 1 247 ? -25.68678 -16.09402 37.33504  1.000 31.68427 ? 247 VAL A O    1 
ATOM   3733 C CB   . VAL A 1 247 ? -27.79383 -13.68515 36.25928  1.000 31.45865 ? 247 VAL A CB   1 
ATOM   3734 C CG1  . VAL A 1 247 ? -27.44397 -13.32657 37.66983  1.000 34.09922 ? 247 VAL A CG1  1 
ATOM   3735 C CG2  . VAL A 1 247 ? -27.84059 -12.43802 35.38837  1.000 30.30416 ? 247 VAL A CG2  1 
ATOM   3736 H H    . VAL A 1 247 ? -27.82575 -14.64168 34.02805  1.000 35.71497 ? 247 VAL A H    1 
ATOM   3737 H HA   . VAL A 1 247 ? -25.90060 -14.26887 35.68315  1.000 35.35551 ? 247 VAL A HA   1 
ATOM   3738 H HB   . VAL A 1 247 ? -28.67506 -14.09052 36.25567  1.000 37.80067 ? 247 VAL A HB   1 
ATOM   3739 H HG11 . VAL A 1 247 ? -26.47868 -13.28213 37.75424  1.000 40.96936 ? 247 VAL A HG11 1 
ATOM   3740 H HG12 . VAL A 1 247 ? -27.83466 -12.46463 37.88273  1.000 40.96936 ? 247 VAL A HG12 1 
ATOM   3741 H HG13 . VAL A 1 247 ? -27.79716 -14.00599 38.26527  1.000 40.96936 ? 247 VAL A HG13 1 
ATOM   3742 H HG21 . VAL A 1 247 ? -28.45154 -11.79799 35.78585  1.000 36.41529 ? 247 VAL A HG21 1 
ATOM   3743 H HG22 . VAL A 1 247 ? -26.95037 -12.05648 35.33509  1.000 36.41529 ? 247 VAL A HG22 1 
ATOM   3744 H HG23 . VAL A 1 247 ? -28.14896 -12.68321 34.50198  1.000 36.41529 ? 247 VAL A HG23 1 
ATOM   3745 N N    . ASP A 1 248 ? -27.65001 -16.83122 36.52297  1.000 32.81568 ? 248 ASP A N    1 
ATOM   3746 C CA   . ASP A 1 248 ? -27.59903 -18.03597 37.35053  1.000 34.28193 ? 248 ASP A CA   1 
ATOM   3747 C C    . ASP A 1 248 ? -26.41127 -18.91597 36.97639  1.000 34.40000 ? 248 ASP A C    1 
ATOM   3748 O O    . ASP A 1 248 ? -25.71414 -19.44641 37.84944  1.000 35.19640 ? 248 ASP A O    1 
ATOM   3749 C CB   . ASP A 1 248 ? -28.89099 -18.83680 37.21228  1.000 38.32898 ? 248 ASP A CB   1 
ATOM   3750 C CG   . ASP A 1 248 ? -30.07112 -18.15411 37.85982  1.000 41.60734 ? 248 ASP A CG   1 
ATOM   3751 O OD1  . ASP A 1 248 ? -29.86333 -17.29099 38.74306  1.000 39.45599 ? 248 ASP A OD1  1 
ATOM   3752 O OD2  . ASP A 1 248 ? -31.21060 -18.49528 37.47917  1.000 42.12625 ? 248 ASP A OD2  1 
ATOM   3753 H H    . ASP A 1 248 ? -28.34493 -16.76637 36.02049  1.000 39.42910 ? 248 ASP A H    1 
ATOM   3754 H HA   . ASP A 1 248 ? -27.50606 -17.76055 38.27595  1.000 41.18861 ? 248 ASP A HA   1 
ATOM   3755 H HB2  . ASP A 1 248 ? -29.09146 -18.95380 36.27046  1.000 46.04506 ? 248 ASP A HB2  1 
ATOM   3756 H HB3  . ASP A 1 248 ? -28.77431 -19.70127 37.63652  1.000 46.04506 ? 248 ASP A HB3  1 
ATOM   3757 N N    . ILE A 1 249 ? -26.17795 -19.08890 35.67774  1.000 36.78448 ? 249 ILE A N    1 
ATOM   3758 C CA   . ILE A 1 249 ? -25.05508 -19.89741 35.22325  1.000 33.35596 ? 249 ILE A CA   1 
ATOM   3759 C C    . ILE A 1 249 ? -23.74680 -19.35536 35.78526  1.000 32.89097 ? 249 ILE A C    1 
ATOM   3760 O O    . ILE A 1 249 ? -22.82953 -20.11979 36.10972  1.000 34.43879 ? 249 ILE A O    1 
ATOM   3761 C CB   . ILE A 1 249 ? -25.04395 -19.94390 33.68706  1.000 33.59353 ? 249 ILE A CB   1 
ATOM   3762 C CG1  . ILE A 1 249 ? -26.08854 -20.94564 33.19365  1.000 33.54525 ? 249 ILE A CG1  1 
ATOM   3763 C CG2  . ILE A 1 249 ? -23.68514 -20.32195 33.18268  1.000 37.05757 ? 249 ILE A CG2  1 
ATOM   3764 C CD1  . ILE A 1 249 ? -26.74874 -20.54894 31.88818  1.000 39.43947 ? 249 ILE A CD1  1 
ATOM   3765 H H    . ILE A 1 249 ? -26.65199 -18.75095 35.04475  1.000 44.19167 ? 249 ILE A H    1 
ATOM   3766 H HA   . ILE A 1 249 ? -25.16040 -20.80296 35.55460  1.000 40.07744 ? 249 ILE A HA   1 
ATOM   3767 H HB   . ILE A 1 249 ? -25.26291 -19.06183 33.34808  1.000 40.36252 ? 249 ILE A HB   1 
ATOM   3768 H HG12 . ILE A 1 249 ? -25.65754 -21.80401 33.05823  1.000 40.30459 ? 249 ILE A HG12 1 
ATOM   3769 H HG13 . ILE A 1 249 ? -26.78448 -21.02603 33.86455  1.000 40.30459 ? 249 ILE A HG13 1 
ATOM   3770 H HG21 . ILE A 1 249 ? -23.07982 -19.57588 33.31634  1.000 44.51938 ? 249 ILE A HG21 1 
ATOM   3771 H HG22 . ILE A 1 249 ? -23.36973 -21.09607 33.67477  1.000 44.51938 ? 249 ILE A HG22 1 
ATOM   3772 H HG23 . ILE A 1 249 ? -23.74643 -20.53302 32.23791  1.000 44.51938 ? 249 ILE A HG23 1 
ATOM   3773 H HD11 . ILE A 1 249 ? -26.99878 -19.61277 31.93244  1.000 47.37765 ? 249 ILE A HD11 1 
ATOM   3774 H HD12 . ILE A 1 249 ? -26.12173 -20.68985 31.16160  1.000 47.37765 ? 249 ILE A HD12 1 
ATOM   3775 H HD13 . ILE A 1 249 ? -27.53835 -21.09624 31.75451  1.000 47.37765 ? 249 ILE A HD13 1 
ATOM   3776 N N    . LEU A 1 250 ? -23.63640 -18.03981 35.90534  1.000 34.39146 ? 250 LEU A N    1 
ATOM   3777 C CA   . LEU A 1 250 ? -22.44783 -17.43696 36.49181  1.000 34.87342 ? 250 LEU A CA   1 
ATOM   3778 C C    . LEU A 1 250 ? -22.43047 -17.54135 38.01228  1.000 35.05441 ? 250 LEU A C    1 
ATOM   3779 O O    . LEU A 1 250 ? -21.43940 -17.13905 38.63126  1.000 34.51399 ? 250 LEU A O    1 
ATOM   3780 C CB   . LEU A 1 250 ? -22.34659 -15.97446 36.05082  1.000 30.07666 ? 250 LEU A CB   1 
ATOM   3781 C CG   . LEU A 1 250 ? -22.11900 -15.80890 34.54445  1.000 29.98007 ? 250 LEU A CG   1 
ATOM   3782 C CD1  . LEU A 1 250 ? -22.40955 -14.40285 34.05923  1.000 28.14654 ? 250 LEU A CD1  1 
ATOM   3783 C CD2  . LEU A 1 250 ? -20.67558 -16.20612 34.20567  1.000 26.35862 ? 250 LEU A CD2  1 
ATOM   3784 H H    . LEU A 1 250 ? -24.23506 -17.47534 35.65516  1.000 41.32004 ? 250 LEU A H    1 
ATOM   3785 H HA   . LEU A 1 250 ? -21.65737 -17.89416 36.16464  1.000 41.89840 ? 250 LEU A HA   1 
ATOM   3786 H HB2  . LEU A 1 250 ? -23.17294 -15.52089 36.27953  1.000 36.14229 ? 250 LEU A HB2  1 
ATOM   3787 H HB3  . LEU A 1 250 ? -21.60146 -15.55936 36.51273  1.000 36.14229 ? 250 LEU A HB3  1 
ATOM   3788 H HG   . LEU A 1 250 ? -22.73934 -16.38904 34.07593  1.000 36.02637 ? 250 LEU A HG   1 
ATOM   3789 H HD11 . LEU A 1 250 ? -21.61586 -13.85780 34.17702  1.000 33.82614 ? 250 LEU A HD11 1 
ATOM   3790 H HD12 . LEU A 1 250 ? -22.65144 -14.43641 33.12047  1.000 33.82614 ? 250 LEU A HD12 1 
ATOM   3791 H HD13 . LEU A 1 250 ? -23.14298 -14.03539 34.57687  1.000 33.82614 ? 250 LEU A HD13 1 
ATOM   3792 H HD21 . LEU A 1 250 ? -20.46068 -15.88631 33.31547  1.000 31.68064 ? 250 LEU A HD21 1 
ATOM   3793 H HD22 . LEU A 1 250 ? -20.07694 -15.80472 34.85482  1.000 31.68064 ? 250 LEU A HD22 1 
ATOM   3794 H HD23 . LEU A 1 250 ? -20.59820 -17.17250 34.23760  1.000 31.68064 ? 250 LEU A HD23 1 
ATOM   3795 N N    . GLY A 1 251 ? -23.48405 -18.08838 38.61884  1.000 37.29055 ? 251 GLY A N    1 
ATOM   3796 C CA   . GLY A 1 251 ? -23.59293 -18.19260 40.05472  1.000 36.75399 ? 251 GLY A CA   1 
ATOM   3797 C C    . GLY A 1 251 ? -22.34776 -18.73728 40.72804  1.000 38.58416 ? 251 GLY A C    1 
ATOM   3798 O O    . GLY A 1 251 ? -21.78385 -18.11672 41.63338  1.000 39.67080 ? 251 GLY A O    1 
ATOM   3799 H H    . GLY A 1 251 ? -24.16235 -18.41248 38.20116  1.000 44.79895 ? 251 GLY A H    1 
ATOM   3800 H HA2  . GLY A 1 251 ? -23.77079 -17.31259 40.42194  1.000 44.15508 ? 251 GLY A HA2  1 
ATOM   3801 H HA3  . GLY A 1 251 ? -24.33251 -18.78114 40.27275  1.000 44.15508 ? 251 GLY A HA3  1 
ATOM   3802 N N    . PRO A 1 252 ? -21.90422 -19.91821 40.30440  1.000 38.74110 ? 252 PRO A N    1 
ATOM   3803 C CA   . PRO A 1 252 ? -20.70411 -20.50407 40.92878  1.000 39.02131 ? 252 PRO A CA   1 
ATOM   3804 C C    . PRO A 1 252 ? -19.45898 -19.63421 40.82600  1.000 40.78199 ? 252 PRO A C    1 
ATOM   3805 O O    . PRO A 1 252 ? -18.64824 -19.62617 41.76075  1.000 43.03961 ? 252 PRO A O    1 
ATOM   3806 C CB   . PRO A 1 252 ? -20.54230 -21.83185 40.17515  1.000 41.24261 ? 252 PRO A CB   1 
ATOM   3807 C CG   . PRO A 1 252 ? -21.95314 -22.19516 39.77409  1.000 40.66902 ? 252 PRO A CG   1 
ATOM   3808 C CD   . PRO A 1 252 ? -22.63896 -20.89050 39.47032  1.000 38.81975 ? 252 PRO A CD   1 
ATOM   3809 H HA   . PRO A 1 252 ? -20.88159 -20.67828 41.86636  1.000 46.87586 ? 252 PRO A HA   1 
ATOM   3810 H HB2  . PRO A 1 252 ? -19.97674 -21.70817 39.39686  1.000 49.54142 ? 252 PRO A HB2  1 
ATOM   3811 H HB3  . PRO A 1 252 ? -20.15929 -22.50418 40.76011  1.000 49.54142 ? 252 PRO A HB3  1 
ATOM   3812 H HG2  . PRO A 1 252 ? -21.93438 -22.76493 38.98929  1.000 48.85311 ? 252 PRO A HG2  1 
ATOM   3813 H HG3  . PRO A 1 252 ? -22.39433 -22.65349 40.50634  1.000 48.85311 ? 252 PRO A HG3  1 
ATOM   3814 H HD2  . PRO A 1 252 ? -22.55806 -20.66884 38.52946  1.000 46.63400 ? 252 PRO A HD2  1 
ATOM   3815 H HD3  . PRO A 1 252 ? -23.57463 -20.92515 39.72374  1.000 46.63400 ? 252 PRO A HD3  1 
ATOM   3816 N N    . LEU A 1 253 ? -19.26727 -18.91722 39.71841  1.000 38.68221 ? 253 LEU A N    1 
ATOM   3817 C CA   . LEU A 1 253 ? -18.11069 -18.03147 39.61284  1.000 36.99155 ? 253 LEU A CA   1 
ATOM   3818 C C    . LEU A 1 253 ? -18.33032 -16.75739 40.42174  1.000 37.33044 ? 253 LEU A C    1 
ATOM   3819 O O    . LEU A 1 253 ? -17.38626 -16.21853 41.01114  1.000 37.40505 ? 253 LEU A O    1 
ATOM   3820 C CB   . LEU A 1 253 ? -17.83129 -17.69501 38.14826  1.000 34.75528 ? 253 LEU A CB   1 
ATOM   3821 C CG   . LEU A 1 253 ? -17.42184 -18.81907 37.19124  1.000 32.62784 ? 253 LEU A CG   1 
ATOM   3822 C CD1  . LEU A 1 253 ? -17.30242 -18.26272 35.76957  1.000 29.77045 ? 253 LEU A CD1  1 
ATOM   3823 C CD2  . LEU A 1 253 ? -16.13005 -19.46703 37.65107  1.000 33.95534 ? 253 LEU A CD2  1 
ATOM   3824 H H    . LEU A 1 253 ? -19.78118 -18.92562 39.02890  1.000 46.46894 ? 253 LEU A H    1 
ATOM   3825 H HA   . LEU A 1 253 ? -17.32819 -18.48701 39.96079  1.000 44.44015 ? 253 LEU A HA   1 
ATOM   3826 H HB2  . LEU A 1 253 ? -18.63930 -17.30356 37.78114  1.000 41.75663 ? 253 LEU A HB2  1 
ATOM   3827 H HB3  . LEU A 1 253 ? -17.11098 -17.04555 38.13198  1.000 41.75663 ? 253 LEU A HB3  1 
ATOM   3828 H HG   . LEU A 1 253 ? -18.09870 -19.51386 37.18523  1.000 39.20369 ? 253 LEU A HG   1 
ATOM   3829 H HD11 . LEU A 1 253 ? -16.99583 -18.96848 35.17898  1.000 35.77483 ? 253 LEU A HD11 1 
ATOM   3830 H HD12 . LEU A 1 253 ? -18.17204 -17.94435 35.48095  1.000 35.77483 ? 253 LEU A HD12 1 
ATOM   3831 H HD13 . LEU A 1 253 ? -16.66550 -17.53112 35.76922  1.000 35.77483 ? 253 LEU A HD13 1 
ATOM   3832 H HD21 . LEU A 1 253 ? -15.86497 -20.13792 37.00257  1.000 40.79670 ? 253 LEU A HD21 1 
ATOM   3833 H HD22 . LEU A 1 253 ? -15.44299 -18.78600 37.72214  1.000 40.79670 ? 253 LEU A HD22 1 
ATOM   3834 H HD23 . LEU A 1 253 ? -16.27521 -19.88195 38.51575  1.000 40.79670 ? 253 LEU A HD23 1 
ATOM   3835 N N    . SER A 1 254 ? -19.57298 -16.26345 40.44789  1.000 36.76623 ? 254 SER A N    1 
ATOM   3836 C CA   A SER A 1 254 ? -19.88816 -15.11293 41.28215  0.710 39.35424 ? 254 SER A CA   1 
ATOM   3837 C CA   B SER A 1 254 ? -19.89270 -15.11138 41.28174  0.290 38.09263 ? 254 SER A CA   1 
ATOM   3838 C C    . SER A 1 254 ? -19.71355 -15.45027 42.75556  1.000 38.87771 ? 254 SER A C    1 
ATOM   3839 O O    . SER A 1 254 ? -19.03279 -14.72915 43.49562  1.000 40.31344 ? 254 SER A O    1 
ATOM   3840 C CB   A SER A 1 254 ? -21.31512 -14.63979 41.02089  0.710 37.19408 ? 254 SER A CB   1 
ATOM   3841 C CB   B SER A 1 254 ? -21.32293 -14.64229 41.00360  0.290 38.76578 ? 254 SER A CB   1 
ATOM   3842 O OG   A SER A 1 254 ? -21.61925 -13.54185 41.86323  0.710 37.12017 ? 254 SER A OG   1 
ATOM   3843 O OG   B SER A 1 254 ? -22.27956 -15.61820 41.38280  0.290 37.32749 ? 254 SER A OG   1 
ATOM   3844 H H    A SER A 1 254 ? -20.23678 -16.57420 39.99800  0.710 44.16976 ? 254 SER A H    1 
ATOM   3845 H H    B SER A 1 254 ? -20.23620 -16.57500 39.99769  0.290 44.16976 ? 254 SER A H    1 
ATOM   3846 H HA   A SER A 1 254 ? -19.28306 -14.39087 41.05112  0.710 47.27537 ? 254 SER A HA   1 
ATOM   3847 H HA   B SER A 1 254 ? -19.29231 -14.38249 41.06006  0.290 45.76145 ? 254 SER A HA   1 
ATOM   3848 H HB2  A SER A 1 254 ? -21.39605 -14.36411 40.09442  0.710 44.68319 ? 254 SER A HB2  1 
ATOM   3849 H HB2  B SER A 1 254 ? -21.48868 -13.83039 41.50782  0.290 46.56922 ? 254 SER A HB2  1 
ATOM   3850 H HB3  A SER A 1 254 ? -21.93161 -15.36540 41.20618  0.710 44.68319 ? 254 SER A HB3  1 
ATOM   3851 H HB3  B SER A 1 254 ? -21.41493 -14.46763 40.05390  0.290 46.56922 ? 254 SER A HB3  1 
ATOM   3852 H HG   A SER A 1 254 ? -21.08017 -12.91334 41.72190  0.710 44.59449 ? 254 SER A HG   1 
ATOM   3853 H HG   B SER A 1 254 ? -23.05414 -15.34459 41.20737  0.290 44.84328 ? 254 SER A HG   1 
ATOM   3854 N N    . ALA A 1 255 ? -20.32999 -16.54508 43.20146  1.000 43.19796 ? 255 ALA A N    1 
ATOM   3855 C CA   . ALA A 1 255 ? -20.13546 -16.98685 44.57546  1.000 42.93780 ? 255 ALA A CA   1 
ATOM   3856 C C    . ALA A 1 255 ? -18.65580 -17.19756 44.85502  1.000 42.07419 ? 255 ALA A C    1 
ATOM   3857 O O    . ALA A 1 255 ? -18.11401 -16.69387 45.84237  1.000 51.64911 ? 255 ALA A O    1 
ATOM   3858 C CB   . ALA A 1 255 ? -20.91464 -18.27614 44.82774  1.000 44.91251 ? 255 ALA A CB   1 
ATOM   3859 H H    . ALA A 1 255 ? -20.85652 -17.03975 42.73491  1.000 51.88784 ? 255 ALA A H    1 
ATOM   3860 H HA   . ALA A 1 255 ? -20.47590 -16.30938 45.18047  1.000 51.57565 ? 255 ALA A HA   1 
ATOM   3861 H HB1  . ALA A 1 255 ? -20.75345 -18.56955 45.73814  1.000 53.94531 ? 255 ALA A HB1  1 
ATOM   3862 H HB2  . ALA A 1 255 ? -21.86043 -18.10403 44.69823  1.000 53.94531 ? 255 ALA A HB2  1 
ATOM   3863 H HB3  . ALA A 1 255 ? -20.61335 -18.95454 44.20333  1.000 53.94531 ? 255 ALA A HB3  1 
ATOM   3864 N N    . GLN A 1 256 ? -17.98291 -17.91954 43.96432  1.000 45.26829 ? 256 GLN A N    1 
ATOM   3865 C CA   . GLN A 1 256 ? -16.58719 -18.26716 44.19007  1.000 48.11302 ? 256 GLN A CA   1 
ATOM   3866 C C    . GLN A 1 256 ? -15.68254 -17.03818 44.28470  1.000 46.40665 ? 256 GLN A C    1 
ATOM   3867 O O    . GLN A 1 256 ? -14.63624 -17.10404 44.93666  1.000 50.25651 ? 256 GLN A O    1 
ATOM   3868 C CB   . GLN A 1 256 ? -16.12734 -19.20662 43.07909  1.000 48.05183 ? 256 GLN A CB   1 
ATOM   3869 C CG   . GLN A 1 256 ? -14.70458 -19.68542 43.20326  1.000 55.29623 ? 256 GLN A CG   1 
ATOM   3870 C CD   . GLN A 1 256 ? -14.29866 -20.59092 42.05564  1.000 64.42814 ? 256 GLN A CD   1 
ATOM   3871 O OE1  . GLN A 1 256 ? -15.13615 -21.25132 41.43675  1.000 67.36720 ? 256 GLN A OE1  1 
ATOM   3872 N NE2  . GLN A 1 256 ? -13.00570 -20.62038 41.76000  1.000 54.20206 ? 256 GLN A NE2  1 
ATOM   3873 H H    . GLN A 1 256 ? -18.30913 -18.21813 43.22674  1.000 54.37224 ? 256 GLN A H    1 
ATOM   3874 H HA   . GLN A 1 256 ? -16.50697 -18.72850 45.03956  1.000 57.78592 ? 256 GLN A HA   1 
ATOM   3875 H HB2  . GLN A 1 256 ? -16.69970 -19.98975 43.08204  1.000 57.71249 ? 256 GLN A HB2  1 
ATOM   3876 H HB3  . GLN A 1 256 ? -16.20547 -18.74179 42.23131  1.000 57.71249 ? 256 GLN A HB3  1 
ATOM   3877 H HG2  . GLN A 1 256 ? -14.11052 -18.91863 43.20722  1.000 66.40577 ? 256 GLN A HG2  1 
ATOM   3878 H HG3  . GLN A 1 256 ? -14.60816 -20.18407 44.02967  1.000 66.40577 ? 256 GLN A HG3  1 
ATOM   3879 H HE21 . GLN A 1 256 ? -12.45059 -20.14238 42.21052  1.000 65.09276 ? 256 GLN A HE21 1 
ATOM   3880 H HE22 . GLN A 1 256 ? -12.72266 -21.11748 41.11783  1.000 65.09276 ? 256 GLN A HE22 1 
ATOM   3881 N N    . THR A 1 257 ? -16.05699 -15.91053 43.66006  1.000 45.86923 ? 257 THR A N    1 
ATOM   3882 C CA   . THR A 1 257 ? -15.23503 -14.70030 43.70556  1.000 42.63960 ? 257 THR A CA   1 
ATOM   3883 C C    . THR A 1 257 ? -15.77866 -13.62215 44.63687  1.000 44.25893 ? 257 THR A C    1 
ATOM   3884 O O    . THR A 1 257 ? -15.08287 -12.63109 44.88241  1.000 42.60551 ? 257 THR A O    1 
ATOM   3885 C CB   . THR A 1 257 ? -15.09750 -14.06750 42.31140  1.000 43.75014 ? 257 THR A CB   1 
ATOM   3886 O OG1  . THR A 1 257 ? -16.39800 -13.90484 41.72435  1.000 40.06158 ? 257 THR A OG1  1 
ATOM   3887 C CG2  . THR A 1 257 ? -14.22520 -14.91385 41.40542  1.000 46.00748 ? 257 THR A CG2  1 
ATOM   3888 H H    . THR A 1 257 ? -16.78219 -15.82627 43.20554  1.000 55.09336 ? 257 THR A H    1 
ATOM   3889 H HA   . THR A 1 257 ? -14.35655 -14.97234 44.01404  1.000 51.21781 ? 257 THR A HA   1 
ATOM   3890 H HB   . THR A 1 257 ? -14.67290 -13.19961 42.39731  1.000 52.55045 ? 257 THR A HB   1 
ATOM   3891 H HG1  . THR A 1 257 ? -16.43075 -13.18436 41.29372  1.000 48.12419 ? 257 THR A HG1  1 
ATOM   3892 H HG21 . THR A 1 257 ? -14.59991 -15.80463 41.32168  1.000 55.25927 ? 257 THR A HG21 1 
ATOM   3893 H HG22 . THR A 1 257 ? -14.17205 -14.51063 40.52481  1.000 55.25927 ? 257 THR A HG22 1 
ATOM   3894 H HG23 . THR A 1 257 ? -13.33094 -14.98197 41.77496  1.000 55.25927 ? 257 THR A HG23 1 
ATOM   3895 N N    . GLY A 1 258 ? -17.00812 -13.76838 45.12113  1.000 43.55153 ? 258 GLY A N    1 
ATOM   3896 C CA   . GLY A 1 258 ? -17.64219 -12.70021 45.85937  1.000 43.35920 ? 258 GLY A CA   1 
ATOM   3897 C C    . GLY A 1 258 ? -17.99999 -11.47680 45.04600  1.000 42.96637 ? 258 GLY A C    1 
ATOM   3898 O O    . GLY A 1 258 ? -18.30930 -10.43637 45.63482  1.000 45.45366 ? 258 GLY A O    1 
ATOM   3899 H H    . GLY A 1 258 ? -17.48886 -14.47595 45.03267  1.000 52.31213 ? 258 GLY A H    1 
ATOM   3900 H HA2  . GLY A 1 258 ? -18.46039 -13.04066 46.25377  1.000 52.08133 ? 258 GLY A HA2  1 
ATOM   3901 H HA3  . GLY A 1 258 ? -17.04379 -12.41720 46.56839  1.000 52.08133 ? 258 GLY A HA3  1 
ATOM   3902 N N    . ILE A 1 259 ? -17.96934 -11.55744 43.71669  1.000 39.21027 ? 259 ILE A N    1 
ATOM   3903 C CA   . ILE A 1 259 ? -18.30298 -10.42622 42.85772  1.000 39.01334 ? 259 ILE A CA   1 
ATOM   3904 C C    . ILE A 1 259 ? -19.67187 -10.67131 42.24627  1.000 35.80152 ? 259 ILE A C    1 
ATOM   3905 O O    . ILE A 1 259 ? -19.85181 -11.61462 41.46424  1.000 34.77867 ? 259 ILE A O    1 
ATOM   3906 C CB   . ILE A 1 259 ? -17.26595 -10.19913 41.74809  1.000 39.58582 ? 259 ILE A CB   1 
ATOM   3907 C CG1  . ILE A 1 259 ? -15.87141 -10.07998 42.34778  1.000 44.62454 ? 259 ILE A CG1  1 
ATOM   3908 C CG2  . ILE A 1 259 ? -17.64021 -8.94598  40.94462  1.000 35.83691 ? 259 ILE A CG2  1 
ATOM   3909 C CD1  . ILE A 1 259 ? -14.82143 -9.67716  41.35133  1.000 44.52930 ? 259 ILE A CD1  1 
ATOM   3910 H H    . ILE A 1 259 ? -17.75464 -12.26915 43.28429  1.000 47.10261 ? 259 ILE A H    1 
ATOM   3911 H HA   . ILE A 1 259 ? -18.34047 -9.63232  43.41379  1.000 46.86630 ? 259 ILE A HA   1 
ATOM   3912 H HB   . ILE A 1 259 ? -17.26398 -10.96050 41.14708  1.000 47.55328 ? 259 ILE A HB   1 
ATOM   3913 H HG12 . ILE A 1 259 ? -15.88863 -9.40934  43.04839  1.000 53.59974 ? 259 ILE A HG12 1 
ATOM   3914 H HG13 . ILE A 1 259 ? -15.61561 -10.93950 42.71751  1.000 53.59974 ? 259 ILE A HG13 1 
ATOM   3915 H HG21 . ILE A 1 259 ? -17.66667 -8.18323  41.54328  1.000 43.05458 ? 259 ILE A HG21 1 
ATOM   3916 H HG22 . ILE A 1 259 ? -16.97342 -8.80222  40.25496  1.000 43.05458 ? 259 ILE A HG22 1 
ATOM   3917 H HG23 . ILE A 1 259 ? -18.51155 -9.07903  40.53968  1.000 43.05458 ? 259 ILE A HG23 1 
ATOM   3918 H HD11 . ILE A 1 259 ? -13.94499 -9.85784  41.72562  1.000 53.48545 ? 259 ILE A HD11 1 
ATOM   3919 H HD12 . ILE A 1 259 ? -14.94551 -10.18971 40.53721  1.000 53.48545 ? 259 ILE A HD12 1 
ATOM   3920 H HD13 . ILE A 1 259 ? -14.91177 -8.72995  41.16287  1.000 53.48545 ? 259 ILE A HD13 1 
ATOM   3921 N N    . ALA A 1 260 ? -20.62098 -9.80445  42.57530  1.000 33.18294 ? 260 ALA A N    1 
ATOM   3922 C CA   . ALA A 1 260 ? -21.95540 -9.91618  42.01106  1.000 31.54926 ? 260 ALA A CA   1 
ATOM   3923 C C    . ALA A 1 260 ? -21.89474 -9.83099  40.49298  1.000 28.60685 ? 260 ALA A C    1 
ATOM   3924 O O    . ALA A 1 260 ? -21.12696 -9.04758  39.92578  1.000 28.66519 ? 260 ALA A O    1 
ATOM   3925 C CB   . ALA A 1 260 ? -22.85654 -8.81347  42.56007  1.000 29.84984 ? 260 ALA A CB   1 
ATOM   3926 H H    . ALA A 1 260 ? -20.51780 -9.14682  43.11980  1.000 39.86982 ? 260 ALA A H    1 
ATOM   3927 H HA   . ALA A 1 260 ? -22.33947 -10.77193 42.25822  1.000 37.90941 ? 260 ALA A HA   1 
ATOM   3928 H HB1  . ALA A 1 260 ? -23.75446 -8.93838  42.21506  1.000 35.87010 ? 260 ALA A HB1  1 
ATOM   3929 H HB2  . ALA A 1 260 ? -22.86422 -8.86490  43.52868  1.000 35.87010 ? 260 ALA A HB2  1 
ATOM   3930 H HB3  . ALA A 1 260 ? -22.51030 -7.95263  42.27728  1.000 35.87010 ? 260 ALA A HB3  1 
ATOM   3931 N N    . VAL A 1 261 ? -22.72607 -10.63142 39.83003  1.000 26.95166 ? 261 VAL A N    1 
ATOM   3932 C CA   . VAL A 1 261 ? -22.73160 -10.63454 38.37174  1.000 27.87100 ? 261 VAL A CA   1 
ATOM   3933 C C    . VAL A 1 261 ? -22.96652 -9.22716  37.82802  1.000 25.91109 ? 261 VAL A C    1 
ATOM   3934 O O    . VAL A 1 261 ? -22.32179 -8.80833  36.85934  1.000 25.63092 ? 261 VAL A O    1 
ATOM   3935 C CB   . VAL A 1 261 ? -23.78762 -11.62466 37.85075  1.000 30.78465 ? 261 VAL A CB   1 
ATOM   3936 C CG1  . VAL A 1 261 ? -23.91558 -11.51223 36.35226  1.000 30.40070 ? 261 VAL A CG1  1 
ATOM   3937 C CG2  . VAL A 1 261 ? -23.40909 -13.04072 38.23947  1.000 33.15631 ? 261 VAL A CG2  1 
ATOM   3938 H H    . VAL A 1 261 ? -23.28660 -11.17237 40.19441  1.000 32.39228 ? 261 VAL A H    1 
ATOM   3939 H HA   . VAL A 1 261 ? -21.86011 -10.92737 38.06246  1.000 33.49549 ? 261 VAL A HA   1 
ATOM   3940 H HB   . VAL A 1 261 ? -24.64654 -11.41261 38.24849  1.000 36.99187 ? 261 VAL A HB   1 
ATOM   3941 H HG11 . VAL A 1 261 ? -23.09452 -11.14203 35.99209  1.000 36.53113 ? 261 VAL A HG11 1 
ATOM   3942 H HG12 . VAL A 1 261 ? -24.07099 -12.39498 35.98147  1.000 36.53113 ? 261 VAL A HG12 1 
ATOM   3943 H HG13 . VAL A 1 261 ? -24.66159 -10.92905 36.14188  1.000 36.53113 ? 261 VAL A HG13 1 
ATOM   3944 H HG21 . VAL A 1 261 ? -22.48549 -13.20055 37.98982  1.000 39.83786 ? 261 VAL A HG21 1 
ATOM   3945 H HG22 . VAL A 1 261 ? -23.51527 -13.14415 39.19808  1.000 39.83786 ? 261 VAL A HG22 1 
ATOM   3946 H HG23 . VAL A 1 261 ? -23.99001 -13.66215 37.77336  1.000 39.83786 ? 261 VAL A HG23 1 
ATOM   3947 N N    . LEU A 1 262 ? -23.88824 -8.47760  38.43294  1.000 25.61462 ? 262 LEU A N    1 
ATOM   3948 C CA   . LEU A 1 262 ? -24.18850 -7.14718  37.91333  1.000 26.02200 ? 262 LEU A CA   1 
ATOM   3949 C C    . LEU A 1 262 ? -23.04351 -6.17651  38.16676  1.000 25.35866 ? 262 LEU A C    1 
ATOM   3950 O O    . LEU A 1 262 ? -22.85208 -5.22863  37.39445  1.000 25.42502 ? 262 LEU A O    1 
ATOM   3951 C CB   . LEU A 1 262 ? -25.48852 -6.62391  38.51953  1.000 28.29851 ? 262 LEU A CB   1 
ATOM   3952 C CG   . LEU A 1 262 ? -26.75507 -7.36815  38.09115  1.000 30.46612 ? 262 LEU A CG   1 
ATOM   3953 C CD1  . LEU A 1 262 ? -27.99268 -6.83868  38.81005  1.000 29.32114 ? 262 LEU A CD1  1 
ATOM   3954 C CD2  . LEU A 1 262 ? -26.94717 -7.25803  36.59666  1.000 26.74148 ? 262 LEU A CD2  1 
ATOM   3955 H H    . LEU A 1 262 ? -24.34094 -8.70998  39.12624  1.000 30.78783 ? 262 LEU A H    1 
ATOM   3956 H HA   . LEU A 1 262 ? -24.31811 -7.20716  36.95390  1.000 31.27669 ? 262 LEU A HA   1 
ATOM   3957 H HB2  . LEU A 1 262 ? -25.42427 -6.69204  39.48500  1.000 34.00850 ? 262 LEU A HB2  1 
ATOM   3958 H HB3  . LEU A 1 262 ? -25.59501 -5.69569  38.25881  1.000 34.00850 ? 262 LEU A HB3  1 
ATOM   3959 H HG   . LEU A 1 262 ? -26.65051 -8.30186  38.33229  1.000 36.60963 ? 262 LEU A HG   1 
ATOM   3960 H HD11 . LEU A 1 262 ? -28.77054 -7.33048  38.50350  1.000 35.23566 ? 262 LEU A HD11 1 
ATOM   3961 H HD12 . LEU A 1 262 ? -27.87939 -6.96107  39.76560  1.000 35.23566 ? 262 LEU A HD12 1 
ATOM   3962 H HD13 . LEU A 1 262 ? -28.09645 -5.89579  38.60734  1.000 35.23566 ? 262 LEU A HD13 1 
ATOM   3963 H HD21 . LEU A 1 262 ? -26.32328 -6.60359  36.24544  1.000 32.14007 ? 262 LEU A HD21 1 
ATOM   3964 H HD22 . LEU A 1 262 ? -26.78089 -8.12388  36.19224  1.000 32.14007 ? 262 LEU A HD22 1 
ATOM   3965 H HD23 . LEU A 1 262 ? -27.85783 -6.97757  36.41514  1.000 32.14007 ? 262 LEU A HD23 1 
ATOM   3966 N N    . ASP A 1 263 ? -22.27405 -6.38344  39.23893  1.000 26.06351 ? 263 ASP A N    1 
ATOM   3967 C CA   . ASP A 1 263 ? -21.05242 -5.61016  39.42665  1.000 26.30729 ? 263 ASP A CA   1 
ATOM   3968 C C    . ASP A 1 263 ? -20.05250 -5.90120  38.31471  1.000 26.67352 ? 263 ASP A C    1 
ATOM   3969 O O    . ASP A 1 263 ? -19.45720 -4.98513  37.73636  1.000 29.18515 ? 263 ASP A O    1 
ATOM   3970 C CB   . ASP A 1 263 ? -20.42632 -5.92651  40.78341  1.000 27.13514 ? 263 ASP A CB   1 
ATOM   3971 C CG   . ASP A 1 263 ? -21.26207 -5.44042  41.94407  1.000 28.65360 ? 263 ASP A CG   1 
ATOM   3972 O OD1  . ASP A 1 263 ? -22.35841 -4.89264  41.71328  1.000 28.26020 ? 263 ASP A OD1  1 
ATOM   3973 O OD2  . ASP A 1 263 ? -20.81500 -5.61830  43.09545  1.000 29.19014 ? 263 ASP A OD2  1 
ATOM   3974 H H    . ASP A 1 263 ? -22.43654 -6.95605  39.85966  1.000 31.32650 ? 263 ASP A H    1 
ATOM   3975 H HA   . ASP A 1 263 ? -21.27926 -4.66724  39.40805  1.000 31.61904 ? 263 ASP A HA   1 
ATOM   3976 H HB2  . ASP A 1 263 ? -20.32624 -6.88759  40.86839  1.000 32.61246 ? 263 ASP A HB2  1 
ATOM   3977 H HB3  . ASP A 1 263 ? -19.55861 -5.49645  40.83851  1.000 32.61246 ? 263 ASP A HB3  1 
ATOM   3978 N N    . MET A 1 264 ? -19.83535 -7.18074  38.01228  1.000 26.83979 ? 264 MET A N    1 
ATOM   3979 C CA   . MET A 1 264 ? -18.96577 -7.51396  36.89103  1.000 28.14250 ? 264 MET A CA   1 
ATOM   3980 C C    . MET A 1 264 ? -19.51311 -6.92653  35.59231  1.000 27.04656 ? 264 MET A C    1 
ATOM   3981 O O    . MET A 1 264 ? -18.74666 -6.42096  34.76229  1.000 28.12359 ? 264 MET A O    1 
ATOM   3982 C CB   . MET A 1 264 ? -18.80595 -9.03196  36.79854  1.000 28.79408 ? 264 MET A CB   1 
ATOM   3983 C CG   . MET A 1 264 ? -17.70650 -9.48854  35.86388  1.000 25.66876 ? 264 MET A CG   1 
ATOM   3984 S SD   . MET A 1 264 ? -16.07650 -8.91389  36.38499  1.000 27.25473 ? 264 MET A SD   1 
ATOM   3985 C CE   . MET A 1 264 ? -15.55980 -10.28915 37.38533  1.000 26.71154 ? 264 MET A CE   1 
ATOM   3986 H H    . MET A 1 264 ? -20.17029 -7.85430  38.42911  1.000 32.25804 ? 264 MET A H    1 
ATOM   3987 H HA   . MET A 1 264 ? -18.08279 -7.14241  37.04333  1.000 33.82130 ? 264 MET A HA   1 
ATOM   3988 H HB2  . MET A 1 264 ? -18.60165 -9.37596  37.68218  1.000 34.60318 ? 264 MET A HB2  1 
ATOM   3989 H HB3  . MET A 1 264 ? -19.63932 -9.41191  36.47912  1.000 34.60318 ? 264 MET A HB3  1 
ATOM   3990 H HG2  . MET A 1 264 ? -17.69126 -10.45816 35.84161  1.000 30.85280 ? 264 MET A HG2  1 
ATOM   3991 H HG3  . MET A 1 264 ? -17.87952 -9.13897  34.97575  1.000 30.85280 ? 264 MET A HG3  1 
ATOM   3992 H HE1  . MET A 1 264 ? -15.01593 -9.96002  38.11798  1.000 32.10413 ? 264 MET A HE1  1 
ATOM   3993 H HE2  . MET A 1 264 ? -16.34539 -10.73961 37.73292  1.000 32.10413 ? 264 MET A HE2  1 
ATOM   3994 H HE3  . MET A 1 264 ? -15.04265 -10.90088 36.83830  1.000 32.10413 ? 264 MET A HE3  1 
ATOM   3995 N N    . CYS A 1 265 ? -20.83489 -6.95299  35.40636  1.000 25.69370 ? 265 CYS A N    1 
ATOM   3996 C CA   . CYS A 1 265 ? -21.41344 -6.33031  34.21627  1.000 26.47664 ? 265 CYS A CA   1 
ATOM   3997 C C    . CYS A 1 265 ? -21.00655 -4.86957  34.10938  1.000 27.36646 ? 265 CYS A C    1 
ATOM   3998 O O    . CYS A 1 265 ? -20.74706 -4.36215  33.01251  1.000 27.70557 ? 265 CYS A O    1 
ATOM   3999 C CB   . CYS A 1 265 ? -22.93231 -6.45171  34.25040  1.000 27.33511 ? 265 CYS A CB   1 
ATOM   4000 S SG   . CYS A 1 265 ? -23.51237 -8.10075  33.84179  1.000 25.23985 ? 265 CYS A SG   1 
ATOM   4001 H H    . CYS A 1 265 ? -21.40357 -7.31546  35.94005  1.000 30.88273 ? 265 CYS A H    1 
ATOM   4002 H HA   . CYS A 1 265 ? -21.08767 -6.79652  33.43051  1.000 31.82226 ? 265 CYS A HA   1 
ATOM   4003 H HB2  . CYS A 1 265 ? -23.24532 -6.23659  35.14296  1.000 32.85242 ? 265 CYS A HB2  1 
ATOM   4004 H HB3  . CYS A 1 265 ? -23.31211 -5.83262  33.60746  1.000 32.85242 ? 265 CYS A HB3  1 
ATOM   4005 H HG   . CYS A 1 265 ? -23.19990 -8.35593  32.71163  1.000 30.33811 ? 265 CYS A HG   1 
ATOM   4006 N N    . ALA A 1 266 ? -20.95557 -4.17550  35.24564  1.000 28.03294 ? 266 ALA A N    1 
ATOM   4007 C CA   . ALA A 1 266 ? -20.54625 -2.77994  35.24016  1.000 31.00718 ? 266 ALA A CA   1 
ATOM   4008 C C    . ALA A 1 266 ? -19.08734 -2.63766  34.82674  1.000 31.06761 ? 266 ALA A C    1 
ATOM   4009 O O    . ALA A 1 266 ? -18.72253 -1.67427  34.14243  1.000 32.45894 ? 266 ALA A O    1 
ATOM   4010 C CB   . ALA A 1 266 ? -20.77145 -2.16545  36.61931  1.000 29.78387 ? 266 ALA A CB   1 
ATOM   4011 H H    . ALA A 1 266 ? -21.15114 -4.48795  36.02264  1.000 33.68982 ? 266 ALA A H    1 
ATOM   4012 H HA   . ALA A 1 266 ? -21.09113 -2.29536  34.60048  1.000 37.25890 ? 266 ALA A HA   1 
ATOM   4013 H HB1  . ALA A 1 266 ? -20.51191 -1.23114  36.59495  1.000 35.79094 ? 266 ALA A HB1  1 
ATOM   4014 H HB2  . ALA A 1 266 ? -21.71060 -2.24198  36.84960  1.000 35.79094 ? 266 ALA A HB2  1 
ATOM   4015 H HB3  . ALA A 1 266 ? -20.23160 -2.64188  37.26929  1.000 35.79094 ? 266 ALA A HB3  1 
ATOM   4016 N N    . SER A 1 267 ? -18.23776 -3.57783  35.24859  1.000 31.28163 ? 267 SER A N    1 
ATOM   4017 C CA   . SER A 1 267 ? -16.85644 -3.58738  34.78242  1.000 31.53480 ? 267 SER A CA   1 
ATOM   4018 C C    . SER A 1 267 ? -16.78593 -3.79610  33.27537  1.000 30.98372 ? 267 SER A C    1 
ATOM   4019 O O    . SER A 1 267 ? -15.99343 -3.14180  32.58513  1.000 32.52057 ? 267 SER A O    1 
ATOM   4020 C CB   . SER A 1 267 ? -16.06885 -4.69406  35.48555  1.000 35.29749 ? 267 SER A CB   1 
ATOM   4021 O OG   . SER A 1 267 ? -15.75594 -4.35131  36.82074  1.000 36.40152 ? 267 SER A OG   1 
ATOM   4022 H H    . SER A 1 267 ? -18.43551 -4.21068  35.79631  1.000 37.58825 ? 267 SER A H    1 
ATOM   4023 H HA   . SER A 1 267 ? -16.45495 -2.73185  35.00100  1.000 37.89206 ? 267 SER A HA   1 
ATOM   4024 H HB2  . SER A 1 267 ? -16.60369 -5.50327  35.48876  1.000 42.40728 ? 267 SER A HB2  1 
ATOM   4025 H HB3  . SER A 1 267 ? -15.24235 -4.84458  35.00064  1.000 42.40728 ? 267 SER A HB3  1 
ATOM   4026 H HG   . SER A 1 267 ? -15.03746 -3.91680  36.84497  1.000 43.73212 ? 267 SER A HG   1 
ATOM   4027 N N    . LEU A 1 268 ? -17.57684 -4.73479  32.75601  1.000 28.08466 ? 268 LEU A N    1 
ATOM   4028 C CA   . LEU A 1 268 ? -17.56687 -4.99199  31.32233  1.000 27.65752 ? 268 LEU A CA   1 
ATOM   4029 C C    . LEU A 1 268 ? -18.02605 -3.76098  30.55594  1.000 28.78486 ? 268 LEU A C    1 
ATOM   4030 O O    . LEU A 1 268 ? -17.42770 -3.39122  29.53825  1.000 30.06981 ? 268 LEU A O    1 
ATOM   4031 C CB   . LEU A 1 268 ? -18.45264 -6.19245  31.00895  1.000 25.36961 ? 268 LEU A CB   1 
ATOM   4032 C CG   . LEU A 1 268 ? -18.63229 -6.52620  29.53144  1.000 26.33500 ? 268 LEU A CG   1 
ATOM   4033 C CD1  . LEU A 1 268 ? -17.28840 -6.61134  28.82260  1.000 28.26724 ? 268 LEU A CD1  1 
ATOM   4034 C CD2  . LEU A 1 268 ? -19.38242 -7.84128  29.38692  1.000 24.54947 ? 268 LEU A CD2  1 
ATOM   4035 H H    . LEU A 1 268 ? -18.11905 -5.22772  33.20613  1.000 33.75188 ? 268 LEU A H    1 
ATOM   4036 H HA   . LEU A 1 268 ? -16.66539 -5.20663  31.03567  1.000 33.23931 ? 268 LEU A HA   1 
ATOM   4037 H HB2  . LEU A 1 268 ? -18.06475 -6.97320  31.43422  1.000 30.49382 ? 268 LEU A HB2  1 
ATOM   4038 H HB3  . LEU A 1 268 ? -19.33491 -6.02011  31.37336  1.000 30.49382 ? 268 LEU A HB3  1 
ATOM   4039 H HG   . LEU A 1 268 ? -19.14610 -5.81979  29.10969  1.000 31.65229 ? 268 LEU A HG   1 
ATOM   4040 H HD11 . LEU A 1 268 ? -16.66874 -7.10851  29.37915  1.000 33.97098 ? 268 LEU A HD11 1 
ATOM   4041 H HD12 . LEU A 1 268 ? -17.40741 -7.06488  27.97346  1.000 33.97098 ? 268 LEU A HD12 1 
ATOM   4042 H HD13 . LEU A 1 268 ? -16.95237 -5.71364  28.67388  1.000 33.97098 ? 268 LEU A HD13 1 
ATOM   4043 H HD21 . LEU A 1 268 ? -19.93631 -7.97679  30.17161  1.000 29.50965 ? 268 LEU A HD21 1 
ATOM   4044 H HD22 . LEU A 1 268 ? -19.93788 -7.80237  28.59266  1.000 29.50965 ? 268 LEU A HD22 1 
ATOM   4045 H HD23 . LEU A 1 268 ? -18.74035 -8.56390  29.30646  1.000 29.50965 ? 268 LEU A HD23 1 
ATOM   4046 N N    . LYS A 1 269 ? -19.07955 -3.10468  31.04105  1.000 30.06873 ? 269 LYS A N    1 
ATOM   4047 C CA   . LYS A 1 269 ? -19.56681 -1.89070  30.39898  1.000 32.55753 ? 269 LYS A CA   1 
ATOM   4048 C C    . LYS A 1 269 ? -18.44874 -0.86990  30.25417  1.000 32.26221 ? 269 LYS A C    1 
ATOM   4049 O O    . LYS A 1 269 ? -18.25899 -0.28170  29.18360  1.000 32.63130 ? 269 LYS A O    1 
ATOM   4050 C CB   . LYS A 1 269 ? -20.73441 -1.33156  31.21261  1.000 34.01735 ? 269 LYS A CB   1 
ATOM   4051 C CG   . LYS A 1 269 ? -21.17353 0.08619   30.87993  1.000 44.50284 ? 269 LYS A CG   1 
ATOM   4052 C CD   . LYS A 1 269 ? -22.33764 0.48268   31.79688  1.000 49.67846 ? 269 LYS A CD   1 
ATOM   4053 C CE   . LYS A 1 269 ? -22.79166 1.92083   31.61042  1.000 57.10040 ? 269 LYS A CE   1 
ATOM   4054 N NZ   . LYS A 1 269 ? -23.99320 2.19645   32.45676  1.000 66.54130 ? 269 LYS A NZ   1 
ATOM   4055 H H    . LYS A 1 269 ? -19.52623 -3.34136  31.73679  1.000 36.13277 ? 269 LYS A H    1 
ATOM   4056 H HA   . LYS A 1 269 ? -19.89131 -2.09375  29.50770  1.000 39.11933 ? 269 LYS A HA   1 
ATOM   4057 H HB2  . LYS A 1 269 ? -21.50227 -1.90758  31.07300  1.000 40.87111 ? 269 LYS A HB2  1 
ATOM   4058 H HB3  . LYS A 1 269 ? -20.48022 -1.33861  32.14868  1.000 40.87111 ? 269 LYS A HB3  1 
ATOM   4059 H HG2  . LYS A 1 269 ? -20.43741 0.70159   31.02244  1.000 53.45370 ? 269 LYS A HG2  1 
ATOM   4060 H HG3  . LYS A 1 269 ? -21.47026 0.13181   29.95756  1.000 53.45370 ? 269 LYS A HG3  1 
ATOM   4061 H HD2  . LYS A 1 269 ? -23.09487 -0.09397  31.60988  1.000 59.66445 ? 269 LYS A HD2  1 
ATOM   4062 H HD3  . LYS A 1 269 ? -22.05997 0.37670   32.72022  1.000 59.66445 ? 269 LYS A HD3  1 
ATOM   4063 H HE2  . LYS A 1 269 ? -22.08008 2.52442   31.87542  1.000 68.57076 ? 269 LYS A HE2  1 
ATOM   4064 H HE3  . LYS A 1 269 ? -23.02532 2.07116   30.68107  1.000 68.57076 ? 269 LYS A HE3  1 
ATOM   4065 H HZ1  . LYS A 1 269 ? -23.76707 2.19055   33.31753  1.000 79.89985 ? 269 LYS A HZ1  1 
ATOM   4066 H HZ2  . LYS A 1 269 ? -24.33287 2.99340   32.25281  1.000 79.89985 ? 269 LYS A HZ2  1 
ATOM   4067 H HZ3  . LYS A 1 269 ? -24.61345 1.57371   32.31680  1.000 79.89985 ? 269 LYS A HZ3  1 
ATOM   4068 N N    . GLU A 1 270 ? -17.67242 -0.66402  31.31710  1.000 31.77591 ? 270 GLU A N    1 
ATOM   4069 C CA   . GLU A 1 270 ? -16.61618 0.33562   31.24512  1.000 36.68708 ? 270 GLU A CA   1 
ATOM   4070 C C    . GLU A 1 270 ? -15.52877 -0.09055  30.26523  1.000 36.67988 ? 270 GLU A C    1 
ATOM   4071 O O    . GLU A 1 270 ? -14.97022 0.74741   29.54666  1.000 36.03456 ? 270 GLU A O    1 
ATOM   4072 C CB   . GLU A 1 270 ? -16.03276 0.59242   32.63339  1.000 44.32660 ? 270 GLU A CB   1 
ATOM   4073 C CG   . GLU A 1 270 ? -17.02171 1.20669   33.62281  1.000 46.81543 ? 270 GLU A CG   1 
ATOM   4074 C CD   . GLU A 1 270 ? -17.58720 2.53618   33.14715  1.000 56.50390 ? 270 GLU A CD   1 
ATOM   4075 O OE1  . GLU A 1 270 ? -16.86655 3.27296   32.43860  1.000 56.31413 ? 270 GLU A OE1  1 
ATOM   4076 O OE2  . GLU A 1 270 ? -18.75567 2.83767   33.47521  1.000 56.03585 ? 270 GLU A OE2  1 
ATOM   4077 H H    . GLU A 1 270 ? -17.73601 -1.07811  32.06816  1.000 38.18138 ? 270 GLU A H    1 
ATOM   4078 H HA   . GLU A 1 270 ? -16.99402 1.17155   30.92990  1.000 44.07479 ? 270 GLU A HA   1 
ATOM   4079 H HB2  . GLU A 1 270 ? -15.73102 -0.25160  33.00418  1.000 53.24221 ? 270 GLU A HB2  1 
ATOM   4080 H HB3  . GLU A 1 270 ? -15.28433 1.20344   32.54731  1.000 53.24221 ? 270 GLU A HB3  1 
ATOM   4081 H HG2  . GLU A 1 270 ? -17.76317 0.59417   33.74910  1.000 56.22881 ? 270 GLU A HG2  1 
ATOM   4082 H HG3  . GLU A 1 270 ? -16.56955 1.35886   34.46739  1.000 56.22881 ? 270 GLU A HG3  1 
ATOM   4083 N N    . LEU A 1 271 ? -15.22752 -1.39066  30.21013  1.000 31.89329 ? 271 LEU A N    1 
ATOM   4084 C CA   . LEU A 1 271 ? -14.24738 -1.88226  29.25042  1.000 31.36275 ? 271 LEU A CA   1 
ATOM   4085 C C    . LEU A 1 271 ? -14.73652 -1.70094  27.82000  1.000 33.04413 ? 271 LEU A C    1 
ATOM   4086 O O    . LEU A 1 271 ? -13.94138 -1.41031  26.91770  1.000 34.39228 ? 271 LEU A O    1 
ATOM   4087 C CB   . LEU A 1 271 ? -13.94183 -3.35340  29.51244  1.000 31.54156 ? 271 LEU A CB   1 
ATOM   4088 C CG   . LEU A 1 271 ? -13.19019 -3.67569  30.79870  1.000 31.67346 ? 271 LEU A CG   1 
ATOM   4089 C CD1  . LEU A 1 271 ? -13.21038 -5.17276  31.02452  1.000 34.82665 ? 271 LEU A CD1  1 
ATOM   4090 C CD2  . LEU A 1 271 ? -11.76203 -3.16702  30.73905  1.000 37.64839 ? 271 LEU A CD2  1 
ATOM   4091 H H    . LEU A 1 271 ? -15.57318 -1.99789  30.71152  1.000 38.32224 ? 271 LEU A H    1 
ATOM   4092 H HA   . LEU A 1 271 ? -13.42791 -1.37568  29.36338  1.000 37.68559 ? 271 LEU A HA   1 
ATOM   4093 H HB2  . LEU A 1 271 ? -14.78412 -3.83323  29.54714  1.000 37.90016 ? 271 LEU A HB2  1 
ATOM   4094 H HB3  . LEU A 1 271 ? -13.40211 -3.68335  28.77709  1.000 37.90016 ? 271 LEU A HB3  1 
ATOM   4095 H HG   . LEU A 1 271 ? -13.62257 -3.23319  31.54579  1.000 38.05844 ? 271 LEU A HG   1 
ATOM   4096 H HD11 . LEU A 1 271 ? -12.76493 -5.37171  31.86290  1.000 41.84227 ? 271 LEU A HD11 1 
ATOM   4097 H HD12 . LEU A 1 271 ? -14.13161 -5.47443  31.05969  1.000 41.84227 ? 271 LEU A HD12 1 
ATOM   4098 H HD13 . LEU A 1 271 ? -12.74724 -5.60886  30.29225  1.000 41.84227 ? 271 LEU A HD13 1 
ATOM   4099 H HD21 . LEU A 1 271 ? -11.62385 -2.52890  31.45641  1.000 45.22836 ? 271 LEU A HD21 1 
ATOM   4100 H HD22 . LEU A 1 271 ? -11.15521 -3.91675  30.84181  1.000 45.22836 ? 271 LEU A HD22 1 
ATOM   4101 H HD23 . LEU A 1 271 ? -11.61523 -2.73777  29.88167  1.000 45.22836 ? 271 LEU A HD23 1 
ATOM   4102 N N    . LEU A 1 272 ? -16.03463 -1.88268  27.58728  1.000 33.27521 ? 272 LEU A N    1 
ATOM   4103 C CA   . LEU A 1 272 ? -16.55227 -1.66985  26.24119  1.000 32.96406 ? 272 LEU A CA   1 
ATOM   4104 C C    . LEU A 1 272 ? -16.47214 -0.19877  25.86341  1.000 35.51573 ? 272 LEU A C    1 
ATOM   4105 O O    . LEU A 1 272 ? -16.04304 0.13929   24.75464  1.000 37.71612 ? 272 LEU A O    1 
ATOM   4106 C CB   . LEU A 1 272 ? -17.99045 -2.16851  26.13761  1.000 33.44287 ? 272 LEU A CB   1 
ATOM   4107 C CG   . LEU A 1 272 ? -18.15730 -3.68622  26.13577  1.000 31.20651 ? 272 LEU A CG   1 
ATOM   4108 C CD1  . LEU A 1 272 ? -19.62518 -4.05925  26.24148  1.000 30.81943 ? 272 LEU A CD1  1 
ATOM   4109 C CD2  . LEU A 1 272 ? -17.56192 -4.29277  24.88113  1.000 35.24122 ? 272 LEU A CD2  1 
ATOM   4110 H H    . LEU A 1 272 ? -16.61762 -2.12137  28.17274  1.000 39.98054 ? 272 LEU A H    1 
ATOM   4111 H HA   . LEU A 1 272 ? -16.01780 -2.18212  25.61442  1.000 39.60717 ? 272 LEU A HA   1 
ATOM   4112 H HB2  . LEU A 1 272 ? -18.48837 -1.82291  26.89493  1.000 40.18173 ? 272 LEU A HB2  1 
ATOM   4113 H HB3  . LEU A 1 272 ? -18.37040 -1.83395  25.31020  1.000 40.18173 ? 272 LEU A HB3  1 
ATOM   4114 H HG   . LEU A 1 272 ? -17.68755 -4.04917  26.90291  1.000 37.49810 ? 272 LEU A HG   1 
ATOM   4115 H HD11 . LEU A 1 272 ? -19.72755 -5.00093  26.03252  1.000 37.03361 ? 272 LEU A HD11 1 
ATOM   4116 H HD12 . LEU A 1 272 ? -19.93074 -3.88594  27.14563  1.000 37.03361 ? 272 LEU A HD12 1 
ATOM   4117 H HD13 . LEU A 1 272 ? -20.13323 -3.52366  25.61225  1.000 37.03361 ? 272 LEU A HD13 1 
ATOM   4118 H HD21 . LEU A 1 272 ? -16.61838 -4.07146  24.84045  1.000 42.33976 ? 272 LEU A HD21 1 
ATOM   4119 H HD22 . LEU A 1 272 ? -17.67480 -5.25570  24.91165  1.000 42.33976 ? 272 LEU A HD22 1 
ATOM   4120 H HD23 . LEU A 1 272 ? -18.02037 -3.93036  24.10693  1.000 42.33976 ? 272 LEU A HD23 1 
ATOM   4121 N N    . GLN A 1 273 ? -16.85372 0.68886   26.78881  1.000 35.63699 ? 273 GLN A N    1 
ATOM   4122 C CA   . GLN A 1 273 ? -16.92340 2.11692   26.51429  1.000 40.42090 ? 273 GLN A CA   1 
ATOM   4123 C C    . GLN A 1 273 ? -15.55412 2.79075   26.49649  1.000 41.30055 ? 273 GLN A C    1 
ATOM   4124 O O    . GLN A 1 273 ? -15.37557 3.79831   25.80100  1.000 41.16449 ? 273 GLN A O    1 
ATOM   4125 C CB   . GLN A 1 273 ? -17.81447 2.79777   27.56398  1.000 41.04569 ? 273 GLN A CB   1 
ATOM   4126 C CG   . GLN A 1 273 ? -19.30578 2.49938   27.42829  1.000 42.78658 ? 273 GLN A CG   1 
ATOM   4127 C CD   . GLN A 1 273 ? -20.12949 3.01023   28.60736  1.000 49.34799 ? 273 GLN A CD   1 
ATOM   4128 O OE1  . GLN A 1 273 ? -19.59149 3.34511   29.66244  1.000 49.34967 ? 273 GLN A OE1  1 
ATOM   4129 N NE2  . GLN A 1 273 ? -21.44202 3.07008   28.42639  1.000 56.91234 ? 273 GLN A NE2  1 
ATOM   4130 H H    . GLN A 1 273 ? -17.07941 0.48217   27.59252  1.000 42.81468 ? 273 GLN A H    1 
ATOM   4131 H HA   . GLN A 1 273 ? -17.31695 2.23700   25.63589  1.000 48.55537 ? 273 GLN A HA   1 
ATOM   4132 H HB2  . GLN A 1 273 ? -17.53617 2.49956   28.44405  1.000 49.30512 ? 273 GLN A HB2  1 
ATOM   4133 H HB3  . GLN A 1 273 ? -17.70098 3.75809   27.48784  1.000 49.30512 ? 273 GLN A HB3  1 
ATOM   4134 H HG2  . GLN A 1 273 ? -19.64006 2.92595   26.62380  1.000 51.39418 ? 273 GLN A HG2  1 
ATOM   4135 H HG3  . GLN A 1 273 ? -19.43057 1.53915   27.37100  1.000 51.39418 ? 273 GLN A HG3  1 
ATOM   4136 H HE21 . GLN A 1 273 ? -21.78403 2.82796   27.67539  1.000 68.34509 ? 273 GLN A HE21 1 
ATOM   4137 H HE22 . GLN A 1 273 ? -21.95109 3.35100   29.06006  1.000 68.34509 ? 273 GLN A HE22 1 
ATOM   4138 N N    . ASN A 1 274 ? -14.58520 2.27162   27.24841  1.000 40.83330 ? 274 ASN A N    1 
ATOM   4139 C CA   . ASN A 1 274 ? -13.30048 2.93327   27.40988  1.000 42.49421 ? 274 ASN A CA   1 
ATOM   4140 C C    . ASN A 1 274 ? -12.12565 2.09382   26.93802  1.000 42.86298 ? 274 ASN A C    1 
ATOM   4141 O O    . ASN A 1 274 ? -10.97504 2.53255   27.06781  1.000 47.28525 ? 274 ASN A O    1 
ATOM   4142 C CB   . ASN A 1 274 ? -13.10034 3.31899   28.88641  1.000 42.18247 ? 274 ASN A CB   1 
ATOM   4143 C CG   . ASN A 1 274 ? -14.31302 4.01860   29.46677  1.000 45.81558 ? 274 ASN A CG   1 
ATOM   4144 O OD1  . ASN A 1 274 ? -14.75678 3.70753   30.57175  1.000 53.45217 ? 274 ASN A OD1  1 
ATOM   4145 N ND2  . ASN A 1 274 ? -14.87097 4.95621   28.70928  1.000 47.15959 ? 274 ASN A ND2  1 
ATOM   4146 H H    . ASN A 1 274 ? -14.65220 1.52956   27.67790  1.000 49.05025 ? 274 ASN A H    1 
ATOM   4147 H HA   . ASN A 1 274 ? -13.29942 3.74688   26.88174  1.000 51.04334 ? 274 ASN A HA   1 
ATOM   4148 H HB2  . ASN A 1 274 ? -12.93775 2.51594   29.40561  1.000 50.66926 ? 274 ASN A HB2  1 
ATOM   4149 H HB3  . ASN A 1 274 ? -12.34207 3.91964   28.95817  1.000 50.66926 ? 274 ASN A HB3  1 
ATOM   4150 H HD21 . ASN A 1 274 ? -15.56170 5.38314   28.99251  1.000 56.64180 ? 274 ASN A HD21 1 
ATOM   4151 H HD22 . ASN A 1 274 ? -14.54150 5.13635   27.93559  1.000 56.64180 ? 274 ASN A HD22 1 
ATOM   4152 N N    . GLY A 1 275 ? -12.37585 0.91940   26.37329  1.000 38.93000 ? 275 GLY A N    1 
ATOM   4153 C CA   . GLY A 1 275 ? -11.28942 0.05732   25.97640  1.000 37.91682 ? 275 GLY A CA   1 
ATOM   4154 C C    . GLY A 1 275 ? -10.43210 -0.32094  27.17573  1.000 42.29914 ? 275 GLY A C    1 
ATOM   4155 O O    . GLY A 1 275 ? -10.71879 0.00437   28.32417  1.000 44.66252 ? 275 GLY A O    1 
ATOM   4156 H H    . GLY A 1 275 ? -13.16062 0.60640   26.21279  1.000 46.76629 ? 275 GLY A H    1 
ATOM   4157 H HA2  . GLY A 1 275 ? -11.64373 -0.75298  25.57793  1.000 45.55047 ? 275 GLY A HA2  1 
ATOM   4158 H HA3  . GLY A 1 275 ? -10.73230 0.51192   25.32536  1.000 45.55047 ? 275 GLY A HA3  1 
ATOM   4159 N N    . MET A 1 276 ? -9.34261  -1.01760  26.87291  1.000 43.43881 ? 276 MET A N    1 
ATOM   4160 C CA   . MET A 1 276 ? -8.44406  -1.51787  27.90338  1.000 44.02696 ? 276 MET A CA   1 
ATOM   4161 C C    . MET A 1 276 ? -7.21816  -0.63645  28.10687  1.000 45.69891 ? 276 MET A C    1 
ATOM   4162 O O    . MET A 1 276 ? -6.32821  -1.00370  28.88000  1.000 43.97942 ? 276 MET A O    1 
ATOM   4163 C CB   . MET A 1 276 ? -8.03433  -2.94852  27.56663  1.000 45.93253 ? 276 MET A CB   1 
ATOM   4164 C CG   . MET A 1 276 ? -9.20975  -3.90836  27.62744  1.000 47.76155 ? 276 MET A CG   1 
ATOM   4165 S SD   . MET A 1 276 ? -8.80892  -5.49840  26.90911  1.000 52.39122 ? 276 MET A SD   1 
ATOM   4166 C CE   . MET A 1 276 ? -7.53777  -6.02819  28.04105  1.000 39.56756 ? 276 MET A CE   1 
ATOM   4167 H H    . MET A 1 276 ? -9.10179  -1.21424  26.07108  1.000 52.17686 ? 276 MET A H    1 
ATOM   4168 H HA   . MET A 1 276 ? -8.92221  -1.53951  28.74706  1.000 52.88265 ? 276 MET A HA   1 
ATOM   4169 H HB2  . MET A 1 276 ? -7.66980  -2.97202  26.66804  1.000 55.16933 ? 276 MET A HB2  1 
ATOM   4170 H HB3  . MET A 1 276 ? -7.36621  -3.24652  28.20358  1.000 55.16933 ? 276 MET A HB3  1 
ATOM   4171 H HG2  . MET A 1 276 ? -9.46067  -4.04807  28.55395  1.000 57.36415 ? 276 MET A HG2  1 
ATOM   4172 H HG3  . MET A 1 276 ? -9.95570  -3.53177  27.13487  1.000 57.36415 ? 276 MET A HG3  1 
ATOM   4173 H HE1  . MET A 1 276 ? -7.59935  -6.98917  28.15777  1.000 47.53136 ? 276 MET A HE1  1 
ATOM   4174 H HE2  . MET A 1 276 ? -6.67078  -5.79443  27.67420  1.000 47.53136 ? 276 MET A HE2  1 
ATOM   4175 H HE3  . MET A 1 276 ? -7.66760  -5.58255  28.89278  1.000 47.53136 ? 276 MET A HE3  1 
ATOM   4176 N N    . ASN A 1 277 ? -7.16397  0.52420   27.45216  1.000 50.98470 ? 277 ASN A N    1 
ATOM   4177 C CA   . ASN A 1 277 ? -6.12096  1.51948   27.71100  1.000 54.05222 ? 277 ASN A CA   1 
ATOM   4178 C C    . ASN A 1 277 ? -4.73513  0.88519   27.72391  1.000 50.08638 ? 277 ASN A C    1 
ATOM   4179 O O    . ASN A 1 277 ? -3.90141  1.16525   28.59135  1.000 48.67461 ? 277 ASN A O    1 
ATOM   4180 C CB   . ASN A 1 277 ? -6.39855  2.26546   29.01651  1.000 52.59241 ? 277 ASN A CB   1 
ATOM   4181 C CG   . ASN A 1 277 ? -7.54803  3.24762   28.89206  1.000 60.75532 ? 277 ASN A CG   1 
ATOM   4182 O OD1  . ASN A 1 277 ? -7.38532  4.33909   28.34682  1.000 64.49024 ? 277 ASN A OD1  1 
ATOM   4183 N ND2  . ASN A 1 277 ? -8.71646  2.86470   29.39752  1.000 61.94863 ? 277 ASN A ND2  1 
ATOM   4184 H H    . ASN A 1 277 ? -7.72608  0.76193   26.84625  1.000 61.23193 ? 277 ASN A H    1 
ATOM   4185 H HA   . ASN A 1 277 ? -6.12927  2.16519   26.98721  1.000 64.91295 ? 277 ASN A HA   1 
ATOM   4186 H HB2  . ASN A 1 277 ? -6.62538  1.62276   29.70671  1.000 63.16118 ? 277 ASN A HB2  1 
ATOM   4187 H HB3  . ASN A 1 277 ? -5.60540  2.76154   29.27287  1.000 63.16118 ? 277 ASN A HB3  1 
ATOM   4188 H HD21 . ASN A 1 277 ? -9.39743  3.38785   29.35065  1.000 74.38865 ? 277 ASN A HD21 1 
ATOM   4189 H HD22 . ASN A 1 277 ? -8.79135  2.09384   29.77138  1.000 74.38865 ? 277 ASN A HD22 1 
ATOM   4190 N N    . GLY A 1 278 ? -4.48063  0.02132   26.74896  1.000 48.65617 ? 278 GLY A N    1 
ATOM   4191 C CA   . GLY A 1 278 ? -3.19055  -0.61220  26.62244  1.000 48.04705 ? 278 GLY A CA   1 
ATOM   4192 C C    . GLY A 1 278 ? -2.89032  -1.67422  27.65198  1.000 46.36966 ? 278 GLY A C    1 
ATOM   4193 O O    . GLY A 1 278 ? -1.77565  -2.21052  27.65413  1.000 46.08737 ? 278 GLY A O    1 
ATOM   4194 H H    . GLY A 1 278 ? -5.04803  -0.21205  26.14631  1.000 58.43770 ? 278 GLY A H    1 
ATOM   4195 H HA2  . GLY A 1 278 ? -3.13459  -1.02682  25.74730  1.000 57.70675 ? 278 GLY A HA2  1 
ATOM   4196 H HA3  . GLY A 1 278 ? -2.50366  0.06898   26.69367  1.000 57.70675 ? 278 GLY A HA3  1 
ATOM   4197 N N    . ARG A 1 279 ? -3.83710  -1.98602  28.53397  1.000 45.22365 ? 279 ARG A N    1 
ATOM   4198 C CA   A ARG A 1 279 ? -3.66342  -3.01772  29.54104  0.500 42.73225 ? 279 ARG A CA   1 
ATOM   4199 C CA   B ARG A 1 279 ? -3.64807  -3.01548  29.53881  0.500 42.74003 ? 279 ARG A CA   1 
ATOM   4200 C C    . ARG A 1 279 ? -4.04840  -4.37183  28.95008  1.000 36.53486 ? 279 ARG A C    1 
ATOM   4201 O O    . ARG A 1 279 ? -4.50748  -4.47150  27.80817  1.000 37.06505 ? 279 ARG A O    1 
ATOM   4202 C CB   A ARG A 1 279 ? -4.50424  -2.71274  30.77856  0.500 45.19333 ? 279 ARG A CB   1 
ATOM   4203 C CB   B ARG A 1 279 ? -4.43038  -2.66325  30.79892  0.500 45.19689 ? 279 ARG A CB   1 
ATOM   4204 C CG   A ARG A 1 279 ? -4.34894  -1.30827  31.34984  0.500 48.44283 ? 279 ARG A CG   1 
ATOM   4205 C CG   B ARG A 1 279 ? -4.04972  -1.29506  31.37229  0.500 48.43269 ? 279 ARG A CG   1 
ATOM   4206 C CD   A ARG A 1 279 ? -3.29163  -1.26339  32.43639  0.500 50.68360 ? 279 ARG A CD   1 
ATOM   4207 C CD   B ARG A 1 279 ? -4.84084  -0.95454  32.62472  0.500 50.96799 ? 279 ARG A CD   1 
ATOM   4208 N NE   A ARG A 1 279 ? -3.63874  -2.10553  33.57490  0.500 54.68469 ? 279 ARG A NE   1 
ATOM   4209 N NE   B ARG A 1 279 ? -5.98314  -0.09011  32.35387  0.500 54.83791 ? 279 ARG A NE   1 
ATOM   4210 C CZ   A ARG A 1 279 ? -2.82704  -2.35764  34.59206  0.500 58.74712 ? 279 ARG A CZ   1 
ATOM   4211 C CZ   B ARG A 1 279 ? -6.00115  1.22247   32.55064  0.500 59.40455 ? 279 ARG A CZ   1 
ATOM   4212 N NH1  A ARG A 1 279 ? -1.60110  -1.86147  34.63642  0.500 67.78939 ? 279 ARG A NH1  1 
ATOM   4213 N NH1  B ARG A 1 279 ? -4.93326  1.87212   32.98601  0.500 66.84738 ? 279 ARG A NH1  1 
ATOM   4214 N NH2  A ARG A 1 279 ? -3.25976  -3.11507  35.59581  0.500 59.95145 ? 279 ARG A NH2  1 
ATOM   4215 N NH2  B ARG A 1 279 ? -7.12002  1.89898   32.31055  0.500 61.46385 ? 279 ARG A NH2  1 
ATOM   4216 H H    . ARG A 1 279 ? -4.60598  -1.60212  28.56632  1.000 54.31867 ? 279 ARG A H    1 
ATOM   4217 H HA   . ARG A 1 279 ? -2.73141  -3.03795  29.80908  1.000 51.33833 ? 279 ARG A HA   1 
ATOM   4218 H HB2  A ARG A 1 279 ? -5.43926  -2.82837  30.54774  0.500 54.28228 ? 279 ARG A HB2  1 
ATOM   4219 H HB2  B ARG A 1 279 ? -5.37708  -2.64735  30.58819  0.500 54.28655 ? 279 ARG A HB2  1 
ATOM   4220 H HB3  A ARG A 1 279 ? -4.25538  -3.33750  31.47759  0.500 54.28228 ? 279 ARG A HB3  1 
ATOM   4221 H HB3  B ARG A 1 279 ? -4.25282  -3.33295  31.47779  0.500 54.28655 ? 279 ARG A HB3  1 
ATOM   4222 H HG2  A ARG A 1 279 ? -4.08400  -0.70084  30.64151  0.500 58.18169 ? 279 ARG A HG2  1 
ATOM   4223 H HG2  B ARG A 1 279 ? -3.10736  -1.29730  31.60221  0.500 58.16952 ? 279 ARG A HG2  1 
ATOM   4224 H HG3  A ARG A 1 279 ? -5.19269  -1.02248  31.73365  0.500 58.18169 ? 279 ARG A HG3  1 
ATOM   4225 H HG3  B ARG A 1 279 ? -4.22751  -0.61092  30.70803  0.500 58.16952 ? 279 ARG A HG3  1 
ATOM   4226 H HD2  A ARG A 1 279 ? -2.44846  -1.57729  32.07387  0.500 60.87061 ? 279 ARG A HD2  1 
ATOM   4227 H HD2  B ARG A 1 279 ? -5.17338  -1.77491  33.02136  0.500 61.21187 ? 279 ARG A HD2  1 
ATOM   4228 H HD3  A ARG A 1 279 ? -3.19780  -0.35112  32.75239  0.500 60.87061 ? 279 ARG A HD3  1 
ATOM   4229 H HD3  B ARG A 1 279 ? -4.25942  -0.49527  33.25076  0.500 61.21187 ? 279 ARG A HD3  1 
ATOM   4230 H HE   A ARG A 1 279 ? -4.42129  -2.46200  33.58730  0.500 65.67192 ? 279 ARG A HE   1 
ATOM   4231 H HE   B ARG A 1 279 ? -6.69668  -0.45703  32.04431  0.500 65.85578 ? 279 ARG A HE   1 
ATOM   4232 H HH11 A ARG A 1 279 ? -1.31536  -1.36341  33.99619  0.500 81.39756 ? 279 ARG A HH11 1 
ATOM   4233 H HH11 B ARG A 1 279 ? -4.20562  1.44339   33.14827  0.500 80.26715 ? 279 ARG A HH11 1 
ATOM   4234 H HH12 A ARG A 1 279 ? -1.09010  -2.03706  35.30549  0.500 81.39756 ? 279 ARG A HH12 1 
ATOM   4235 H HH12 B ARG A 1 279 ? -4.96706  2.72295   33.10662  0.500 80.26715 ? 279 ARG A HH12 1 
ATOM   4236 H HH21 A ARG A 1 279 ? -4.05787  -3.43500  35.58001  0.500 71.99203 ? 279 ARG A HH21 1 
ATOM   4237 H HH21 B ARG A 1 279 ? -7.14316  2.74967   32.43455  0.500 73.80691 ? 279 ARG A HH21 1 
ATOM   4238 H HH22 A ARG A 1 279 ? -2.74147  -3.28495  36.26073  0.500 71.99203 ? 279 ARG A HH22 1 
ATOM   4239 H HH22 B ARG A 1 279 ? -7.82071  1.48593   32.03122  0.500 73.80691 ? 279 ARG A HH22 1 
ATOM   4240 N N    . THR A 1 280 ? -3.87117  -5.43617  29.73056  1.000 34.53558 ? 280 THR A N    1 
ATOM   4241 C CA   . THR A 1 280 ? -4.23264  -6.76436  29.26552  1.000 33.19562 ? 280 THR A CA   1 
ATOM   4242 C C    . THR A 1 280 ? -4.92564  -7.53657  30.37486  1.000 33.72007 ? 280 THR A C    1 
ATOM   4243 O O    . THR A 1 280 ? -4.76823  -7.24753  31.56385  1.000 33.72866 ? 280 THR A O    1 
ATOM   4244 C CB   . THR A 1 280 ? -3.01362  -7.56467  28.78502  1.000 34.54055 ? 280 THR A CB   1 
ATOM   4245 O OG1  . THR A 1 280 ? -2.13923  -7.81358  29.89302  1.000 35.09038 ? 280 THR A OG1  1 
ATOM   4246 C CG2  . THR A 1 280 ? -2.28792  -6.79969  27.69456  1.000 36.40992 ? 280 THR A CG2  1 
ATOM   4247 H H    . THR A 1 280 ? -3.54568  -5.41049  30.52618  1.000 41.49298 ? 280 THR A H    1 
ATOM   4248 H HA   . THR A 1 280 ? -4.85243  -6.66205  28.52640  1.000 39.88503 ? 280 THR A HA   1 
ATOM   4249 H HB   . THR A 1 280 ? -3.29355  -8.41664  28.41531  1.000 41.49895 ? 280 THR A HB   1 
ATOM   4250 H HG1  . THR A 1 280 ? -2.50928  -8.33259  30.44009  1.000 42.15875 ? 280 THR A HG1  1 
ATOM   4251 H HG21 . THR A 1 280 ? -1.99560  -5.93846  28.03177  1.000 43.74219 ? 280 THR A HG21 1 
ATOM   4252 H HG22 . THR A 1 280 ? -1.51255  -7.30106  27.39736  1.000 43.74219 ? 280 THR A HG22 1 
ATOM   4253 H HG23 . THR A 1 280 ? -2.87947  -6.65764  26.93905  1.000 43.74219 ? 280 THR A HG23 1 
ATOM   4254 N N    . ILE A 1 281 ? -5.68763  -8.53823  29.95540  1.000 31.24770 ? 281 ILE A N    1 
ATOM   4255 C CA   . ILE A 1 281 ? -6.45332  -9.40649  30.84318  1.000 30.99974 ? 281 ILE A CA   1 
ATOM   4256 C C    . ILE A 1 281 ? -6.12335  -10.83535 30.44442  1.000 30.72476 ? 281 ILE A C    1 
ATOM   4257 O O    . ILE A 1 281 ? -6.33611  -11.22360 29.28913  1.000 29.28041 ? 281 ILE A O    1 
ATOM   4258 C CB   . ILE A 1 281 ? -7.96015  -9.12287  30.73252  1.000 32.45349 ? 281 ILE A CB   1 
ATOM   4259 C CG1  . ILE A 1 281 ? -8.24828  -7.68373  31.18857  1.000 35.30978 ? 281 ILE A CG1  1 
ATOM   4260 C CG2  . ILE A 1 281 ? -8.77601  -10.11490 31.53900  1.000 31.04247 ? 281 ILE A CG2  1 
ATOM   4261 C CD1  . ILE A 1 281 ? -9.67469  -7.19457  30.90338  1.000 38.78147 ? 281 ILE A CD1  1 
ATOM   4262 H H    . ILE A 1 281 ? -5.78181  -8.74417  29.12575  1.000 37.54753 ? 281 ILE A H    1 
ATOM   4263 H HA   . ILE A 1 281 ? -6.19258  -9.27904  31.76875  1.000 37.24998 ? 281 ILE A HA   1 
ATOM   4264 H HB   . ILE A 1 281 ? -8.21979  -9.22337  29.80334  1.000 38.99448 ? 281 ILE A HB   1 
ATOM   4265 H HG12 . ILE A 1 281 ? -8.10710  -7.62985  32.14673  1.000 42.42202 ? 281 ILE A HG12 1 
ATOM   4266 H HG13 . ILE A 1 281 ? -7.63737  -7.08658  30.72912  1.000 42.42202 ? 281 ILE A HG13 1 
ATOM   4267 H HG21 . ILE A 1 281 ? -8.64306  -11.00374 31.17403  1.000 37.30126 ? 281 ILE A HG21 1 
ATOM   4268 H HG22 . ILE A 1 281 ? -8.48124  -10.08914 32.46277  1.000 37.30126 ? 281 ILE A HG22 1 
ATOM   4269 H HG23 . ILE A 1 281 ? -9.71337  -9.87153  31.48398  1.000 37.30126 ? 281 ILE A HG23 1 
ATOM   4270 H HD11 . ILE A 1 281 ? -9.63205  -6.30949  30.50878  1.000 46.58805 ? 281 ILE A HD11 1 
ATOM   4271 H HD12 . ILE A 1 281 ? -10.10278 -7.81061  30.28845  1.000 46.58805 ? 281 ILE A HD12 1 
ATOM   4272 H HD13 . ILE A 1 281 ? -10.16981 -7.16165  31.73685  1.000 46.58805 ? 281 ILE A HD13 1 
ATOM   4273 N N    . LEU A 1 282 ? -5.58053  -11.60689 31.38345  1.000 33.96245 ? 282 LEU A N    1 
ATOM   4274 C CA   . LEU A 1 282 ? -5.17301  -12.98322 31.10350  1.000 30.99880 ? 282 LEU A CA   1 
ATOM   4275 C C    . LEU A 1 282 ? -4.36144  -13.05448 29.81133  1.000 28.33684 ? 282 LEU A C    1 
ATOM   4276 O O    . LEU A 1 282 ? -4.54370  -13.94648 28.98120  1.000 29.50681 ? 282 LEU A O    1 
ATOM   4277 C CB   . LEU A 1 282 ? -6.39222  -13.90606 31.04218  1.000 29.08537 ? 282 LEU A CB   1 
ATOM   4278 C CG   . LEU A 1 282 ? -7.07964  -14.15110 32.38606  1.000 32.02871 ? 282 LEU A CG   1 
ATOM   4279 C CD1  . LEU A 1 282 ? -8.28231  -15.05056 32.23450  1.000 28.56216 ? 282 LEU A CD1  1 
ATOM   4280 C CD2  . LEU A 1 282 ? -6.10833  -14.76384 33.37994  1.000 32.64222 ? 282 LEU A CD2  1 
ATOM   4281 H H    . LEU A 1 282 ? -5.43705  -11.35612 32.19347  1.000 40.80523 ? 282 LEU A H    1 
ATOM   4282 H HA   . LEU A 1 282 ? -4.60177  -13.29355 31.82342  1.000 37.24885 ? 282 LEU A HA   1 
ATOM   4283 H HB2  . LEU A 1 282 ? -7.04745  -13.51004 30.44659  1.000 34.95274 ? 282 LEU A HB2  1 
ATOM   4284 H HB3  . LEU A 1 282 ? -6.10845  -14.76728 30.69766  1.000 34.95274 ? 282 LEU A HB3  1 
ATOM   4285 H HG   . LEU A 1 282 ? -7.38303  -13.29523 32.72715  1.000 38.48474 ? 282 LEU A HG   1 
ATOM   4286 H HD11 . LEU A 1 282 ? -7.98574  -15.97393 32.21592  1.000 34.32488 ? 282 LEU A HD11 1 
ATOM   4287 H HD12 . LEU A 1 282 ? -8.87872  -14.90976 32.98641  1.000 34.32488 ? 282 LEU A HD12 1 
ATOM   4288 H HD13 . LEU A 1 282 ? -8.73731  -14.83254 31.40605  1.000 34.32488 ? 282 LEU A HD13 1 
ATOM   4289 H HD21 . LEU A 1 282 ? -5.54907  -15.40830 32.91864  1.000 39.22095 ? 282 LEU A HD21 1 
ATOM   4290 H HD22 . LEU A 1 282 ? -5.55860  -14.06029 33.75903  1.000 39.22095 ? 282 LEU A HD22 1 
ATOM   4291 H HD23 . LEU A 1 282 ? -6.61141  -15.20516 34.08211  1.000 39.22095 ? 282 LEU A HD23 1 
ATOM   4292 N N    . GLY A 1 283 ? -3.46429  -12.09064 29.62774  1.000 30.96441 ? 283 GLY A N    1 
ATOM   4293 C CA   . GLY A 1 283 ? -2.58199  -12.10458 28.48168  1.000 30.55289 ? 283 GLY A CA   1 
ATOM   4294 C C    . GLY A 1 283 ? -3.20215  -11.67703 27.16935  1.000 33.52641 ? 283 GLY A C    1 
ATOM   4295 O O    . GLY A 1 283 ? -2.54882  -11.80589 26.12655  1.000 34.00837 ? 283 GLY A O    1 
ATOM   4296 H H    . GLY A 1 283 ? -3.35166  -11.42098 30.15545  1.000 37.20759 ? 283 GLY A H    1 
ATOM   4297 H HA2  . GLY A 1 283 ? -1.83724  -11.50932 28.66033  1.000 36.71375 ? 283 GLY A HA2  1 
ATOM   4298 H HA3  . GLY A 1 283 ? -2.24448  -13.00645 28.36502  1.000 36.71375 ? 283 GLY A HA3  1 
ATOM   4299 N N    . SER A 1 284 ? -4.42235  -11.16379 27.18248  1.000 31.24856 ? 284 SER A N    1 
ATOM   4300 C CA   . SER A 1 284 ? -5.08697  -10.71610 25.96942  1.000 29.45460 ? 284 SER A CA   1 
ATOM   4301 C C    . SER A 1 284 ? -5.37343  -9.22512  26.04534  1.000 29.52768 ? 284 SER A C    1 
ATOM   4302 O O    . SER A 1 284 ? -5.65572  -8.68241  27.11604  1.000 31.30174 ? 284 SER A O    1 
ATOM   4303 C CB   . SER A 1 284 ? -6.39194  -11.48385 25.74770  1.000 29.34728 ? 284 SER A CB   1 
ATOM   4304 O OG   . SER A 1 284 ? -7.02299  -11.05575 24.55722  1.000 31.72160 ? 284 SER A OG   1 
ATOM   4305 H H    . SER A 1 284 ? -4.89392  -11.06285 27.89454  1.000 37.54856 ? 284 SER A H    1 
ATOM   4306 H HA   . SER A 1 284 ? -4.50598  -10.86758 25.20758  1.000 35.39581 ? 284 SER A HA   1 
ATOM   4307 H HB2  . SER A 1 284 ? -6.19469  -12.43109 25.67896  1.000 35.26703 ? 284 SER A HB2  1 
ATOM   4308 H HB3  . SER A 1 284 ? -6.98608  -11.32224 26.49721  1.000 35.26703 ? 284 SER A HB3  1 
ATOM   4309 H HG   . SER A 1 284 ? -7.69161  -11.53831 24.39694  1.000 38.11621 ? 284 SER A HG   1 
ATOM   4310 N N    . ALA A 1 285 ? -5.30868  -8.56128  24.88992  1.000 27.92402 ? 285 ALA A N    1 
ATOM   4311 C CA   . ALA A 1 285 ? -5.71327  -7.16809  24.77929  1.000 30.05766 ? 285 ALA A CA   1 
ATOM   4312 C C    . ALA A 1 285 ? -7.10418  -7.00898  24.18133  1.000 31.89792 ? 285 ALA A C    1 
ATOM   4313 O O    . ALA A 1 285 ? -7.48066  -5.89628  23.79979  1.000 33.33972 ? 285 ALA A O    1 
ATOM   4314 C CB   . ALA A 1 285 ? -4.70488  -6.38548  23.93598  1.000 28.42441 ? 285 ALA A CB   1 
ATOM   4315 H H    . ALA A 1 285 ? -5.03045  -8.90387  24.15180  1.000 33.55911 ? 285 ALA A H    1 
ATOM   4316 H HA   . ALA A 1 285 ? -5.72100  -6.78562  25.67067  1.000 36.11948 ? 285 ALA A HA   1 
ATOM   4317 H HB1  . ALA A 1 285 ? -3.88118  -6.28764  24.43882  1.000 34.15958 ? 285 ALA A HB1  1 
ATOM   4318 H HB2  . ALA A 1 285 ? -4.53502  -6.87233  23.11438  1.000 34.15958 ? 285 ALA A HB2  1 
ATOM   4319 H HB3  . ALA A 1 285 ? -5.07397  -5.51182  23.73251  1.000 34.15958 ? 285 ALA A HB3  1 
ATOM   4320 N N    . LEU A 1 286 ? -7.86193  -8.09425  24.07153  1.000 31.06282 ? 286 LEU A N    1 
ATOM   4321 C CA   . LEU A 1 286 ? -9.23494  -8.04838  23.60853  1.000 32.54228 ? 286 LEU A CA   1 
ATOM   4322 C C    . LEU A 1 286 ? -10.09812 -8.79343  24.60878  1.000 28.77758 ? 286 LEU A C    1 
ATOM   4323 O O    . LEU A 1 286 ? -9.60385  -9.59751  25.40195  1.000 27.88272 ? 286 LEU A O    1 
ATOM   4324 C CB   . LEU A 1 286 ? -9.42784  -8.69831  22.24452  1.000 31.28690 ? 286 LEU A CB   1 
ATOM   4325 C CG   . LEU A 1 286 ? -8.60602  -8.20283  21.06747  1.000 33.87146 ? 286 LEU A CG   1 
ATOM   4326 C CD1  . LEU A 1 286 ? -8.99846  -9.03860  19.88162  1.000 29.35341 ? 286 LEU A CD1  1 
ATOM   4327 C CD2  . LEU A 1 286 ? -8.83596  -6.73086  20.80357  1.000 42.48335 ? 286 LEU A CD2  1 
ATOM   4328 H H    . LEU A 1 286 ? -7.59228  -8.88755  24.26537  1.000 37.32567 ? 286 LEU A H    1 
ATOM   4329 H HA   . LEU A 1 286 ? -9.50553  -7.11943  23.53977  1.000 39.10103 ? 286 LEU A HA   1 
ATOM   4330 H HB2  . LEU A 1 286 ? -9.22565  -9.64202  22.34159  1.000 37.59457 ? 286 LEU A HB2  1 
ATOM   4331 H HB3  . LEU A 1 286 ? -10.35846 -8.58217  21.99680  1.000 37.59457 ? 286 LEU A HB3  1 
ATOM   4332 H HG   . LEU A 1 286 ? -7.65651  -8.28909  21.24604  1.000 40.69604 ? 286 LEU A HG   1 
ATOM   4333 H HD11 . LEU A 1 286 ? -9.92250  -8.85031  19.65447  1.000 35.27438 ? 286 LEU A HD11 1 
ATOM   4334 H HD12 . LEU A 1 286 ? -8.42207  -8.81612  19.13383  1.000 35.27438 ? 286 LEU A HD12 1 
ATOM   4335 H HD13 . LEU A 1 286 ? -8.89819  -9.97622  20.10902  1.000 35.27438 ? 286 LEU A HD13 1 
ATOM   4336 H HD21 . LEU A 1 286 ? -9.78680  -6.54575  20.85396  1.000 51.03031 ? 286 LEU A HD21 1 
ATOM   4337 H HD22 . LEU A 1 286 ? -8.36212  -6.21231  21.47251  1.000 51.03031 ? 286 LEU A HD22 1 
ATOM   4338 H HD23 . LEU A 1 286 ? -8.50294  -6.51282  19.91901  1.000 51.03031 ? 286 LEU A HD23 1 
ATOM   4339 N N    . LEU A 1 287 ? -11.39611 -8.54011  24.55504  1.000 27.45807 ? 287 LEU A N    1 
ATOM   4340 C CA   . LEU A 1 287 ? -12.33601 -9.26335  25.40057  1.000 25.42471 ? 287 LEU A CA   1 
ATOM   4341 C C    . LEU A 1 287 ? -12.59782 -10.62399 24.76856  1.000 26.60187 ? 287 LEU A C    1 
ATOM   4342 O O    . LEU A 1 287 ? -13.05103 -10.70280 23.62325  1.000 29.53618 ? 287 LEU A O    1 
ATOM   4343 C CB   . LEU A 1 287 ? -13.61826 -8.46009  25.56361  1.000 26.24136 ? 287 LEU A CB   1 
ATOM   4344 C CG   . LEU A 1 287 ? -13.37773 -7.06851  26.15624  1.000 26.74385 ? 287 LEU A CG   1 
ATOM   4345 C CD1  . LEU A 1 287 ? -14.64333 -6.22640  26.10514  1.000 28.87669 ? 287 LEU A CD1  1 
ATOM   4346 C CD2  . LEU A 1 287 ? -12.86266 -7.18027  27.58473  1.000 28.15079 ? 287 LEU A CD2  1 
ATOM   4347 H H    . LEU A 1 287 ? -11.75858 -7.95555  24.03880  1.000 32.99998 ? 287 LEU A H    1 
ATOM   4348 H HA   . LEU A 1 287 ? -11.96699 -9.40095  26.28702  1.000 30.55994 ? 287 LEU A HA   1 
ATOM   4349 H HB2  . LEU A 1 287 ? -14.03248 -8.34872  24.69360  1.000 31.53992 ? 287 LEU A HB2  1 
ATOM   4350 H HB3  . LEU A 1 287 ? -14.21686 -8.94010  26.15705  1.000 31.53992 ? 287 LEU A HB3  1 
ATOM   4351 H HG   . LEU A 1 287 ? -12.70350 -6.61627  25.62541  1.000 32.14291 ? 287 LEU A HG   1 
ATOM   4352 H HD11 . LEU A 1 287 ? -15.21444 -6.46907  26.85069  1.000 34.70231 ? 287 LEU A HD11 1 
ATOM   4353 H HD12 . LEU A 1 287 ? -14.40152 -5.28895  26.16515  1.000 34.70231 ? 287 LEU A HD12 1 
ATOM   4354 H HD13 . LEU A 1 287 ? -15.10234 -6.39666  25.26775  1.000 34.70231 ? 287 LEU A HD13 1 
ATOM   4355 H HD21 . LEU A 1 287 ? -13.00433 -6.33478  28.03857  1.000 33.83124 ? 287 LEU A HD21 1 
ATOM   4356 H HD22 . LEU A 1 287 ? -13.34738 -7.88585  28.04092  1.000 33.83124 ? 287 LEU A HD22 1 
ATOM   4357 H HD23 . LEU A 1 287 ? -11.91578 -7.38973  27.56354  1.000 33.83124 ? 287 LEU A HD23 1 
ATOM   4358 N N    . GLU A 1 288 ? -12.31633 -11.68995 25.51146  1.000 26.62907 ? 288 GLU A N    1 
ATOM   4359 C CA   A GLU A 1 288 ? -12.39201 -13.04768 24.98909  0.500 27.64480 ? 288 GLU A CA   1 
ATOM   4360 C CA   B GLU A 1 288 ? -12.39280 -13.04627 24.98621  0.500 27.27100 ? 288 GLU A CA   1 
ATOM   4361 C C    . GLU A 1 288 ? -13.75882 -13.64760 25.27937  1.000 24.69079 ? 288 GLU A C    1 
ATOM   4362 O O    . GLU A 1 288 ? -14.21699 -13.63518 26.42664  1.000 24.18458 ? 288 GLU A O    1 
ATOM   4363 C CB   A GLU A 1 288 ? -11.29193 -13.90965 25.61259  0.500 30.56597 ? 288 GLU A CB   1 
ATOM   4364 C CB   B GLU A 1 288 ? -11.29463 -13.91783 25.59526  0.500 29.15133 ? 288 GLU A CB   1 
ATOM   4365 C CG   A GLU A 1 288 ? -11.25498 -15.35040 25.12297  0.500 32.15102 ? 288 GLU A CG   1 
ATOM   4366 C CG   B GLU A 1 288 ? -9.87562  -13.42879 25.32095  0.500 30.92559 ? 288 GLU A CG   1 
ATOM   4367 C CD   A GLU A 1 288 ? -11.11051 -15.45291 23.61988  0.500 33.07952 ? 288 GLU A CD   1 
ATOM   4368 C CD   B GLU A 1 288 ? -9.50813  -13.44323 23.84402  0.500 34.26809 ? 288 GLU A CD   1 
ATOM   4369 O OE1  A GLU A 1 288 ? -10.07893 -14.99196 23.09033  0.500 32.18677 ? 288 GLU A OE1  1 
ATOM   4370 O OE1  B GLU A 1 288 ? -10.07496 -14.25725 23.08634  0.500 32.57082 ? 288 GLU A OE1  1 
ATOM   4371 O OE2  A GLU A 1 288 ? -12.03728 -15.98347 22.96940  0.500 25.46455 ? 288 GLU A OE2  1 
ATOM   4372 O OE2  B GLU A 1 288 ? -8.64420  -12.63545 23.44128  0.500 31.69082 ? 288 GLU A OE2  1 
ATOM   4373 H H    . GLU A 1 288 ? -12.07492 -11.64968 26.33589  1.000 32.00518 ? 288 GLU A H    1 
ATOM   4374 H HA   . GLU A 1 288 ? -12.27161 -13.03255 24.02671  1.000 32.77549 ? 288 GLU A HA   1 
ATOM   4375 H HB2  A GLU A 1 288 ? -10.43295 -13.50923 25.40589  0.500 36.72945 ? 288 GLU A HB2  1 
ATOM   4376 H HB2  B GLU A 1 288 ? -11.41605 -13.94066 26.55736  0.500 35.03189 ? 288 GLU A HB2  1 
ATOM   4377 H HB3  A GLU A 1 288 ? -11.42529 -13.93137 26.57314  0.500 36.72945 ? 288 GLU A HB3  1 
ATOM   4378 H HB3  B GLU A 1 288 ? -11.37206 -14.81299 25.22976  0.500 35.03189 ? 288 GLU A HB3  1 
ATOM   4379 H HG2  A GLU A 1 288 ? -10.49913 -15.80310 25.52874  0.500 38.63151 ? 288 GLU A HG2  1 
ATOM   4380 H HG2  B GLU A 1 288 ? -9.79084  -12.51660 25.63973  0.500 37.16099 ? 288 GLU A HG2  1 
ATOM   4381 H HG3  A GLU A 1 288 ? -12.08088 -15.79174 25.37595  0.500 38.63151 ? 288 GLU A HG3  1 
ATOM   4382 H HG3  B GLU A 1 288 ? -9.24964  -14.00329 25.78892  0.500 37.16099 ? 288 GLU A HG3  1 
ATOM   4383 N N    . ASP A 1 289 ? -14.40440 -14.19486 24.24325  1.000 24.40344 ? 289 ASP A N    1 
ATOM   4384 C CA   . ASP A 1 289 ? -15.73866 -14.75104 24.43174  1.000 23.19289 ? 289 ASP A CA   1 
ATOM   4385 C C    . ASP A 1 289 ? -15.84599 -16.23807 24.09374  1.000 22.15793 ? 289 ASP A C    1 
ATOM   4386 O O    . ASP A 1 289 ? -16.96372 -16.73966 23.97715  1.000 21.54876 ? 289 ASP A O    1 
ATOM   4387 C CB   . ASP A 1 289 ? -16.77630 -13.96193 23.62919  1.000 22.06221 ? 289 ASP A CB   1 
ATOM   4388 C CG   . ASP A 1 289 ? -16.84782 -14.36239 22.15108  1.000 23.89961 ? 289 ASP A CG   1 
ATOM   4389 O OD1  . ASP A 1 289 ? -15.86411 -14.90111 21.59293  1.000 23.31429 ? 289 ASP A OD1  1 
ATOM   4390 O OD2  . ASP A 1 289 ? -17.90856 -14.10121 21.53810  1.000 23.40657 ? 289 ASP A OD2  1 
ATOM   4391 H H    . ASP A 1 289 ? -14.09360 -14.25181 23.44340  1.000 29.33442 ? 289 ASP A H    1 
ATOM   4392 H HA   . ASP A 1 289 ? -15.94286 -14.66534 25.37613  1.000 27.88176 ? 289 ASP A HA   1 
ATOM   4393 H HB2  . ASP A 1 289 ? -17.65198 -14.11122 24.01879  1.000 26.52495 ? 289 ASP A HB2  1 
ATOM   4394 H HB3  . ASP A 1 289 ? -16.55151 -13.01921 23.66969  1.000 26.52495 ? 289 ASP A HB3  1 
ATOM   4395 N N    . GLU A 1 290 ? -14.74549 -16.97764 23.96124  1.000 23.06177 ? 290 GLU A N    1 
ATOM   4396 C CA   . GLU A 1 290 ? -14.87423 -18.38718 23.59532  1.000 23.69582 ? 290 GLU A CA   1 
ATOM   4397 C C    . GLU A 1 290 ? -14.57545 -19.33272 24.75771  1.000 25.82856 ? 290 GLU A C    1 
ATOM   4398 O O    . GLU A 1 290 ? -14.22593 -20.49551 24.54729  1.000 25.03507 ? 290 GLU A O    1 
ATOM   4399 C CB   . GLU A 1 290 ? -14.01615 -18.71698 22.37682  1.000 23.47221 ? 290 GLU A CB   1 
ATOM   4400 C CG   . GLU A 1 290 ? -14.49877 -17.94915 21.15336  1.000 24.81921 ? 290 GLU A CG   1 
ATOM   4401 C CD   . GLU A 1 290 ? -14.33948 -18.69117 19.83790  1.000 27.84503 ? 290 GLU A CD   1 
ATOM   4402 O OE1  . GLU A 1 290 ? -13.64350 -19.72903 19.79950  1.000 28.12155 ? 290 GLU A OE1  1 
ATOM   4403 O OE2  . GLU A 1 290 ? -14.92234 -18.22096 18.83177  1.000 25.70959 ? 290 GLU A OE2  1 
ATOM   4404 H H    . GLU A 1 290 ? -13.94136 -16.69448 24.07439  1.000 27.72442 ? 290 GLU A H    1 
ATOM   4405 H HA   . GLU A 1 290 ? -15.79871 -18.54334 23.34664  1.000 28.48528 ? 290 GLU A HA   1 
ATOM   4406 H HB2  . GLU A 1 290 ? -13.09507 -18.46931 22.55335  1.000 28.21694 ? 290 GLU A HB2  1 
ATOM   4407 H HB3  . GLU A 1 290 ? -14.07399 -19.66667 22.18806  1.000 28.21694 ? 290 GLU A HB3  1 
ATOM   4408 H HG2  . GLU A 1 290 ? -15.44185 -17.75146 21.26484  1.000 29.83334 ? 290 GLU A HG2  1 
ATOM   4409 H HG3  . GLU A 1 290 ? -13.99255 -17.12442 21.08665  1.000 29.83334 ? 290 GLU A HG3  1 
ATOM   4410 N N    . PHE A 1 291 ? -14.78186 -18.86572 25.98768  1.000 23.45626 ? 291 PHE A N    1 
ATOM   4411 C CA   . PHE A 1 291 ? -14.77269 -19.72157 27.16702  1.000 25.38207 ? 291 PHE A CA   1 
ATOM   4412 C C    . PHE A 1 291 ? -16.15037 -19.70307 27.81066  1.000 26.82034 ? 291 PHE A C    1 
ATOM   4413 O O    . PHE A 1 291 ? -16.60998 -18.63706 28.23847  1.000 24.77216 ? 291 PHE A O    1 
ATOM   4414 C CB   . PHE A 1 291 ? -13.76527 -19.23201 28.20483  1.000 26.36134 ? 291 PHE A CB   1 
ATOM   4415 C CG   . PHE A 1 291 ? -12.35193 -19.41639 27.81808  1.000 27.36778 ? 291 PHE A CG   1 
ATOM   4416 C CD1  . PHE A 1 291 ? -11.77029 -20.66141 27.89497  1.000 28.71558 ? 291 PHE A CD1  1 
ATOM   4417 C CD2  . PHE A 1 291 ? -11.58444 -18.33534 27.42730  1.000 29.01567 ? 291 PHE A CD2  1 
ATOM   4418 C CE1  . PHE A 1 291 ? -10.45610 -20.83657 27.56549  1.000 30.88437 ? 291 PHE A CE1  1 
ATOM   4419 C CE2  . PHE A 1 291 ? -10.26676 -18.50195 27.09802  1.000 31.57203 ? 291 PHE A CE2  1 
ATOM   4420 C CZ   . PHE A 1 291 ? -9.70053  -19.75725 27.16292  1.000 28.02943 ? 291 PHE A CZ   1 
ATOM   4421 H H    . PHE A 1 291 ? -14.93249 -18.03790 26.16555  1.000 28.19780 ? 291 PHE A H    1 
ATOM   4422 H HA   . PHE A 1 291 ? -14.54853 -20.62136 26.88235  1.000 30.50877 ? 291 PHE A HA   1 
ATOM   4423 H HB2  . PHE A 1 291 ? -13.90795 -18.28378 28.35114  1.000 31.68390 ? 291 PHE A HB2  1 
ATOM   4424 H HB3  . PHE A 1 291 ? -13.90950 -19.72046 29.03037  1.000 31.68390 ? 291 PHE A HB3  1 
ATOM   4425 H HD1  . PHE A 1 291 ? -12.27650 -21.39006 28.17375  1.000 34.50899 ? 291 PHE A HD1  1 
ATOM   4426 H HD2  . PHE A 1 291 ? -11.96645 -17.48834 27.38785  1.000 34.86909 ? 291 PHE A HD2  1 
ATOM   4427 H HE1  . PHE A 1 291 ? -10.07244 -21.68242 27.61285  1.000 37.11154 ? 291 PHE A HE1  1 
ATOM   4428 H HE2  . PHE A 1 291 ? -9.75571  -17.77199 26.83177  1.000 37.93673 ? 291 PHE A HE2  1 
ATOM   4429 H HZ   . PHE A 1 291 ? -8.80683  -19.87567 26.93451  1.000 33.68561 ? 291 PHE A HZ   1 
ATOM   4430 N N    . THR A 1 292 ? -16.78526 -20.87356 27.93424  1.000 26.48316 ? 292 THR A N    1 
ATOM   4431 C CA   . THR A 1 292 ? -18.03617 -20.95287 28.67746  1.000 28.06374 ? 292 THR A CA   1 
ATOM   4432 C C    . THR A 1 292 ? -17.78678 -20.87314 30.18616  1.000 29.34994 ? 292 THR A C    1 
ATOM   4433 O O    . THR A 1 292 ? -16.67997 -21.13700 30.66241  1.000 28.90654 ? 292 THR A O    1 
ATOM   4434 C CB   . THR A 1 292 ? -18.78647 -22.25917 28.41107  1.000 28.53508 ? 292 THR A CB   1 
ATOM   4435 O OG1  . THR A 1 292 ? -18.04272 -23.35094 28.97636  1.000 30.82236 ? 292 THR A OG1  1 
ATOM   4436 C CG2  . THR A 1 292 ? -19.01209 -22.49345 26.93227  1.000 29.52393 ? 292 THR A CG2  1 
ATOM   4437 H H    . THR A 1 292 ? -16.51415 -21.61903 27.60202  1.000 31.83008 ? 292 THR A H    1 
ATOM   4438 H HA   . THR A 1 292 ? -18.58405 -20.20766 28.38524  1.000 33.72678 ? 292 THR A HA   1 
ATOM   4439 H HB   . THR A 1 292 ? -19.66402 -22.21070 28.82150  1.000 34.29238 ? 292 THR A HB   1 
ATOM   4440 H HG1  . THR A 1 292 ? -18.56884 -23.91715 29.30530  1.000 37.03712 ? 292 THR A HG1  1 
ATOM   4441 H HG21 . THR A 1 292 ? -19.54705 -21.77484 26.56035  1.000 35.47900 ? 292 THR A HG21 1 
ATOM   4442 H HG22 . THR A 1 292 ? -18.16113 -22.52528 26.46779  1.000 35.47900 ? 292 THR A HG22 1 
ATOM   4443 H HG23 . THR A 1 292 ? -19.47641 -23.33423 26.79662  1.000 35.47900 ? 292 THR A HG23 1 
ATOM   4444 N N    . PRO A 1 293 ? -18.81614 -20.52281 30.96009  1.000 27.94329 ? 293 PRO A N    1 
ATOM   4445 C CA   . PRO A 1 293 ? -18.71152 -20.65702 32.41979  1.000 29.15610 ? 293 PRO A CA   1 
ATOM   4446 C C    . PRO A 1 293 ? -18.23113 -22.03286 32.84081  1.000 31.84754 ? 293 PRO A C    1 
ATOM   4447 O O    . PRO A 1 293 ? -17.35135 -22.15105 33.70208  1.000 31.73341 ? 293 PRO A O    1 
ATOM   4448 C CB   . PRO A 1 293 ? -20.14404 -20.37708 32.89511  1.000 28.29084 ? 293 PRO A CB   1 
ATOM   4449 C CG   . PRO A 1 293 ? -20.68303 -19.43705 31.87666  1.000 27.38789 ? 293 PRO A CG   1 
ATOM   4450 C CD   . PRO A 1 293 ? -20.08082 -19.88176 30.55223  1.000 26.44496 ? 293 PRO A CD   1 
ATOM   4451 H HA   . PRO A 1 293 ? -18.12190 -19.97789 32.78317  1.000 35.03761 ? 293 PRO A HA   1 
ATOM   4452 H HB2  . PRO A 1 293 ? -20.65570 -21.20085 32.91787  1.000 33.99930 ? 293 PRO A HB2  1 
ATOM   4453 H HB3  . PRO A 1 293 ? -20.13063 -19.97043 33.77566  1.000 33.99930 ? 293 PRO A HB3  1 
ATOM   4454 H HG2  . PRO A 1 293 ? -21.65083 -19.49805 31.85301  1.000 32.91575 ? 293 PRO A HG2  1 
ATOM   4455 H HG3  . PRO A 1 293 ? -20.41290 -18.53042 32.09098  1.000 32.91575 ? 293 PRO A HG3  1 
ATOM   4456 H HD2  . PRO A 1 293 ? -20.66150 -20.51608 30.10351  1.000 31.78425 ? 293 PRO A HD2  1 
ATOM   4457 H HD3  . PRO A 1 293 ? -19.91266 -19.12030 29.97534  1.000 31.78425 ? 293 PRO A HD3  1 
ATOM   4458 N N    . PHE A 1 294 ? -18.78479 -23.07828 32.23223  1.000 34.28071 ? 294 PHE A N    1 
ATOM   4459 C CA   . PHE A 1 294 ? -18.33972 -24.43899 32.50800  1.000 38.43735 ? 294 PHE A CA   1 
ATOM   4460 C C    . PHE A 1 294 ? -16.84729 -24.59255 32.22209  1.000 38.24178 ? 294 PHE A C    1 
ATOM   4461 O O    . PHE A 1 294 ? -16.10240 -25.13347 33.04515  1.000 40.25714 ? 294 PHE A O    1 
ATOM   4462 C CB   . PHE A 1 294 ? -19.18276 -25.41036 31.68183  1.000 44.81691 ? 294 PHE A CB   1 
ATOM   4463 C CG   . PHE A 1 294 ? -18.88650 -26.85533 31.93430  1.000 56.40088 ? 294 PHE A CG   1 
ATOM   4464 C CD1  . PHE A 1 294 ? -18.86928 -27.36518 33.21996  1.000 61.43235 ? 294 PHE A CD1  1 
ATOM   4465 C CD2  . PHE A 1 294 ? -18.65651 -27.71518 30.87375  1.000 61.99875 ? 294 PHE A CD2  1 
ATOM   4466 C CE1  . PHE A 1 294 ? -18.60651 -28.70259 33.44397  1.000 67.83519 ? 294 PHE A CE1  1 
ATOM   4467 C CE2  . PHE A 1 294 ? -18.39655 -29.05221 31.09107  1.000 66.50375 ? 294 PHE A CE2  1 
ATOM   4468 C CZ   . PHE A 1 294 ? -18.37431 -29.54710 32.37871  1.000 64.42841 ? 294 PHE A CZ   1 
ATOM   4469 H H    . PHE A 1 294 ? -19.42027 -23.02689 31.65506  1.000 41.18714 ? 294 PHE A H    1 
ATOM   4470 H HA   . PHE A 1 294 ? -18.47089 -24.65100 33.44542  1.000 46.17511 ? 294 PHE A HA   1 
ATOM   4471 H HB2  . PHE A 1 294 ? -20.11850 -25.26212 31.88996  1.000 53.83058 ? 294 PHE A HB2  1 
ATOM   4472 H HB3  . PHE A 1 294 ? -19.02075 -25.23777 30.74116  1.000 53.83058 ? 294 PHE A HB3  1 
ATOM   4473 H HD1  . PHE A 1 294 ? -19.03631 -26.80184 33.94082  1.000 73.76911 ? 294 PHE A HD1  1 
ATOM   4474 H HD2  . PHE A 1 294 ? -18.67759 -27.38707 30.00381  1.000 74.44879 ? 294 PHE A HD2  1 
ATOM   4475 H HE1  . PHE A 1 294 ? -18.58618 -29.03345 34.31289  1.000 81.45252 ? 294 PHE A HE1  1 
ATOM   4476 H HE2  . PHE A 1 294 ? -18.23660 -29.61887 30.37120  1.000 79.85479 ? 294 PHE A HE2  1 
ATOM   4477 H HZ   . PHE A 1 294 ? -18.20299 -30.44889 32.52810  1.000 77.36439 ? 294 PHE A HZ   1 
ATOM   4478 N N    . ASP A 1 295 ? -16.38953 -24.09592 31.06442  1.000 38.75955 ? 295 ASP A N    1 
ATOM   4479 C CA   . ASP A 1 295 ? -14.96456 -24.14027 30.73945  1.000 35.85682 ? 295 ASP A CA   1 
ATOM   4480 C C    . ASP A 1 295 ? -14.11220 -23.50508 31.83100  1.000 39.10958 ? 295 ASP A C    1 
ATOM   4481 O O    . ASP A 1 295 ? -13.02726 -24.00195 32.15092  1.000 36.59273 ? 295 ASP A O    1 
ATOM   4482 C CB   . ASP A 1 295 ? -14.69363 -23.42631 29.40906  1.000 35.45963 ? 295 ASP A CB   1 
ATOM   4483 C CG   . ASP A 1 295 ? -15.30966 -24.14021 28.22813  1.000 36.93817 ? 295 ASP A CG   1 
ATOM   4484 O OD1  . ASP A 1 295 ? -15.56923 -25.35685 28.34532  1.000 36.73714 ? 295 ASP A OD1  1 
ATOM   4485 O OD2  . ASP A 1 295 ? -15.53411 -23.48668 27.18504  1.000 32.66327 ? 295 ASP A OD2  1 
ATOM   4486 H H    . ASP A 1 295 ? -16.88014 -23.73259 30.45870  1.000 46.56175 ? 295 ASP A H    1 
ATOM   4487 H HA   . ASP A 1 295 ? -14.71283 -25.07290 30.65145  1.000 43.07847 ? 295 ASP A HA   1 
ATOM   4488 H HB2  . ASP A 1 295 ? -15.06785 -22.53224 29.44793  1.000 42.60184 ? 295 ASP A HB2  1 
ATOM   4489 H HB3  . ASP A 1 295 ? -13.73558 -23.37898 29.26483  1.000 42.60184 ? 295 ASP A HB3  1 
ATOM   4490 N N    . VAL A 1 296 ? -14.57074 -22.38382 32.39171  1.000 36.35290 ? 296 VAL A N    1 
ATOM   4491 C CA   . VAL A 1 296 ? -13.79869 -21.72134 33.43825  1.000 38.32779 ? 296 VAL A CA   1 
ATOM   4492 C C    . VAL A 1 296 ? -13.75892 -22.58743 34.69023  1.000 38.16015 ? 296 VAL A C    1 
ATOM   4493 O O    . VAL A 1 296 ? -12.69101 -22.81570 35.27009  1.000 40.59143 ? 296 VAL A O    1 
ATOM   4494 C CB   . VAL A 1 296 ? -14.37401 -20.32719 33.73892  1.000 32.65451 ? 296 VAL A CB   1 
ATOM   4495 C CG1  . VAL A 1 296 ? -13.49548 -19.58992 34.74478  1.000 35.04954 ? 296 VAL A CG1  1 
ATOM   4496 C CG2  . VAL A 1 296 ? -14.48465 -19.52656 32.46326  1.000 31.85194 ? 296 VAL A CG2  1 
ATOM   4497 H H    . VAL A 1 296 ? -15.31049 -21.99579 32.18726  1.000 43.67377 ? 296 VAL A H    1 
ATOM   4498 H HA   . VAL A 1 296 ? -12.88986 -21.60435 33.12007  1.000 46.04363 ? 296 VAL A HA   1 
ATOM   4499 H HB   . VAL A 1 296 ? -15.25874 -20.42855 34.12347  1.000 39.23571 ? 296 VAL A HB   1 
ATOM   4500 H HG11 . VAL A 1 296 ? -12.56661 -19.68461 34.48186  1.000 42.10973 ? 296 VAL A HG11 1 
ATOM   4501 H HG12 . VAL A 1 296 ? -13.74309 -18.65208 34.75258  1.000 42.10973 ? 296 VAL A HG12 1 
ATOM   4502 H HG13 . VAL A 1 296 ? -13.63115 -19.97517 35.62460  1.000 42.10973 ? 296 VAL A HG13 1 
ATOM   4503 H HG21 . VAL A 1 296 ? -14.67522 -18.60197 32.68623  1.000 38.27262 ? 296 VAL A HG21 1 
ATOM   4504 H HG22 . VAL A 1 296 ? -13.64531 -19.58415 31.98047  1.000 38.27262 ? 296 VAL A HG22 1 
ATOM   4505 H HG23 . VAL A 1 296 ? -15.20282 -19.89127 31.92279  1.000 38.27262 ? 296 VAL A HG23 1 
ATOM   4506 N N    . VAL A 1 297 ? -14.92404 -23.08098 35.12709  1.000 36.63151 ? 297 VAL A N    1 
ATOM   4507 C CA   . VAL A 1 297 ? -14.97986 -23.94533 36.30448  1.000 37.69948 ? 297 VAL A CA   1 
ATOM   4508 C C    . VAL A 1 297 ? -14.15901 -25.21021 36.07364  1.000 45.79660 ? 297 VAL A C    1 
ATOM   4509 O O    . VAL A 1 297 ? -13.31459 -25.58113 36.89815  1.000 46.46183 ? 297 VAL A O    1 
ATOM   4510 C CB   . VAL A 1 297 ? -16.44089 -24.28862 36.65706  1.000 38.04687 ? 297 VAL A CB   1 
ATOM   4511 C CG1  . VAL A 1 297 ? -16.48422 -25.38476 37.71710  1.000 33.16019 ? 297 VAL A CG1  1 
ATOM   4512 C CG2  . VAL A 1 297 ? -17.19470 -23.05723 37.14832  1.000 36.25062 ? 297 VAL A CG2  1 
ATOM   4513 H H    . VAL A 1 297 ? -15.68771 -22.93045 34.76136  1.000 44.00811 ? 297 VAL A H    1 
ATOM   4514 H HA   . VAL A 1 297 ? -14.59342 -23.46390 37.05267  1.000 45.28967 ? 297 VAL A HA   1 
ATOM   4515 H HB   . VAL A 1 297 ? -16.88129 -24.60816 35.85404  1.000 45.70654 ? 297 VAL A HB   1 
ATOM   4516 H HG11 . VAL A 1 297 ? -16.34387 -26.24380 37.28901  1.000 39.84252 ? 297 VAL A HG11 1 
ATOM   4517 H HG12 . VAL A 1 297 ? -15.78450 -25.22169 38.36878  1.000 39.84252 ? 297 VAL A HG12 1 
ATOM   4518 H HG13 . VAL A 1 297 ? -17.35121 -25.36955 38.15185  1.000 39.84252 ? 297 VAL A HG13 1 
ATOM   4519 H HG21 . VAL A 1 297 ? -16.62998 -22.56683 37.76598  1.000 43.55104 ? 297 VAL A HG21 1 
ATOM   4520 H HG22 . VAL A 1 297 ? -17.41610 -22.49803 36.38729  1.000 43.55104 ? 297 VAL A HG22 1 
ATOM   4521 H HG23 . VAL A 1 297 ? -18.00628 -23.34188 37.59688  1.000 43.55104 ? 297 VAL A HG23 1 
ATOM   4522 N N    . ARG A 1 298 ? -14.41132 -25.89979 34.95427  1.000 47.25411 ? 298 ARG A N    1 
ATOM   4523 C CA   . ARG A 1 298 ? -13.66827 -27.11114 34.62190  1.000 46.00592 ? 298 ARG A CA   1 
ATOM   4524 C C    . ARG A 1 298 ? -12.16915 -26.90051 34.75325  1.000 46.51324 ? 298 ARG A C    1 
ATOM   4525 O O    . ARG A 1 298 ? -11.45619 -27.71432 35.35127  1.000 48.51516 ? 298 ARG A O    1 
ATOM   4526 C CB   . ARG A 1 298 ? -13.98355 -27.55044 33.18954  1.000 48.19408 ? 298 ARG A CB   1 
ATOM   4527 C CG   . ARG A 1 298 ? -15.20557 -28.41694 33.03168  1.000 60.67792 ? 298 ARG A CG   1 
ATOM   4528 C CD   . ARG A 1 298 ? -15.08576 -29.28225 31.77417  1.000 75.88478 ? 298 ARG A CD   1 
ATOM   4529 N NE   . ARG A 1 298 ? -15.02056 -28.51276 30.53436  1.000 66.82082 ? 298 ARG A NE   1 
ATOM   4530 C CZ   . ARG A 1 298 ? -13.94405 -28.38500 29.76453  1.000 56.94917 ? 298 ARG A CZ   1 
ATOM   4531 N NH1  . ARG A 1 298 ? -12.78210 -28.92465 30.09754  1.000 49.78966 ? 298 ARG A NH1  1 
ATOM   4532 N NH2  . ARG A 1 298 ? -14.04118 -27.70722 28.62389  1.000 44.09853 ? 298 ARG A NH2  1 
ATOM   4533 H H    . ARG A 1 298 ? -15.00789 -25.68461 34.37341  1.000 56.75522 ? 298 ARG A H    1 
ATOM   4534 H HA   . ARG A 1 298 ? -13.94622 -27.80664 35.23828  1.000 55.25740 ? 298 ARG A HA   1 
ATOM   4535 H HB2  . ARG A 1 298 ? -14.12114 -26.75611 32.65009  1.000 57.88319 ? 298 ARG A HB2  1 
ATOM   4536 H HB3  . ARG A 1 298 ? -13.22672 -28.05416 32.85133  1.000 57.88319 ? 298 ARG A HB3  1 
ATOM   4537 H HG2  . ARG A 1 298 ? -15.29295 -29.00020 33.80180  1.000 72.86380 ? 298 ARG A HG2  1 
ATOM   4538 H HG3  . ARG A 1 298 ? -15.99329 -27.85706 32.94847  1.000 72.86380 ? 298 ARG A HG3  1 
ATOM   4539 H HD2  . ARG A 1 298 ? -14.27585 -29.81249 31.83578  1.000 91.11203 ? 298 ARG A HD2  1 
ATOM   4540 H HD3  . ARG A 1 298 ? -15.85997 -29.86416 31.72040  1.000 91.11203 ? 298 ARG A HD3  1 
ATOM   4541 H HE   . ARG A 1 298 ? -15.73688 -28.10945 30.28172  1.000 80.23527 ? 298 ARG A HE   1 
ATOM   4542 H HH11 . ARG A 1 298 ? -12.70940 -29.37181 30.82854  1.000 59.79788 ? 298 ARG A HH11 1 
ATOM   4543 H HH12 . ARG A 1 298 ? -12.09989 -28.82808 29.58288  1.000 59.79788 ? 298 ARG A HH12 1 
ATOM   4544 H HH21 . ARG A 1 298 ? -14.79292 -27.35890 28.39336  1.000 52.96852 ? 298 ARG A HH21 1 
ATOM   4545 H HH22 . ARG A 1 298 ? -13.35222 -27.61741 28.11707  1.000 52.96852 ? 298 ARG A HH22 1 
ATOM   4546 N N    . GLN A 1 299 ? -11.66634 -25.81940 34.16165  1.000 45.60653 ? 299 GLN A N    1 
ATOM   4547 C CA   . GLN A 1 299 ? -10.22846 -25.60775 34.16083  1.000 50.16573 ? 299 GLN A CA   1 
ATOM   4548 C C    . GLN A 1 299 ? -9.73591  -25.25418 35.55792  1.000 47.48417 ? 299 GLN A C    1 
ATOM   4549 O O    . GLN A 1 299 ? -8.75424  -25.82531 36.04355  1.000 48.37729 ? 299 GLN A O    1 
ATOM   4550 C CB   . GLN A 1 299 ? -9.85207  -24.51783 33.16024  1.000 46.13249 ? 299 GLN A CB   1 
ATOM   4551 C CG   . GLN A 1 299 ? -8.35402  -24.39440 33.00541  1.000 33.32897 ? 299 GLN A CG   1 
ATOM   4552 C CD   . GLN A 1 299 ? -7.91598  -23.56833 31.81313  1.000 31.85129 ? 299 GLN A CD   1 
ATOM   4553 O OE1  . GLN A 1 299 ? -6.83580  -22.99270 31.83905  1.000 28.37794 ? 299 GLN A OE1  1 
ATOM   4554 N NE2  . GLN A 1 299 ? -8.73728  -23.51501 30.76874  1.000 28.21698 ? 299 GLN A NE2  1 
ATOM   4555 H H    . GLN A 1 299 ? -12.12630 -25.21071 33.76476  1.000 54.77813 ? 299 GLN A H    1 
ATOM   4556 H HA   . GLN A 1 299 ? -9.79033  -26.42647 33.88042  1.000 60.24916 ? 299 GLN A HA   1 
ATOM   4557 H HB2  . GLN A 1 299 ? -10.23122 -24.73430 32.29405  1.000 55.40927 ? 299 GLN A HB2  1 
ATOM   4558 H HB3  . GLN A 1 299 ? -10.19767 -23.66614 33.47019  1.000 55.40927 ? 299 GLN A HB3  1 
ATOM   4559 H HG2  . GLN A 1 299 ? -7.99357  -23.97402 33.80181  1.000 40.04505 ? 299 GLN A HG2  1 
ATOM   4560 H HG3  . GLN A 1 299 ? -7.97889  -25.28274 32.90046  1.000 40.04505 ? 299 GLN A HG3  1 
ATOM   4561 H HE21 . GLN A 1 299 ? -9.48476  -23.93990 30.78740  1.000 33.91066 ? 299 GLN A HE21 1 
ATOM   4562 H HE22 . GLN A 1 299 ? -8.52099  -23.05564 30.07463  1.000 33.91066 ? 299 GLN A HE22 1 
ATOM   4563 N N    . CYS A 1 300 ? -10.41941 -24.32750 36.22860  1.000 45.06521 ? 300 CYS A N    1 
ATOM   4564 C CA   . CYS A 1 300 ? -9.97684  -23.87579 37.54102  1.000 53.91766 ? 300 CYS A CA   1 
ATOM   4565 C C    . CYS A 1 300 ? -10.24093 -24.88949 38.64712  1.000 55.40065 ? 300 CYS A C    1 
ATOM   4566 O O    . CYS A 1 300 ? -9.80547  -24.65923 39.78161  1.000 54.38048 ? 300 CYS A O    1 
ATOM   4567 C CB   . CYS A 1 300 ? -10.64971 -22.54169 37.86750  1.000 52.69688 ? 300 CYS A CB   1 
ATOM   4568 S SG   . CYS A 1 300 ? -10.22150 -21.22769 36.69112  1.000 47.08954 ? 300 CYS A SG   1 
ATOM   4569 H H    . CYS A 1 300 ? -11.13763 -23.94862 35.94539  1.000 54.12854 ? 300 CYS A H    1 
ATOM   4570 H HA   . CYS A 1 300 ? -9.01765  -23.73307 37.51911  1.000 64.75148 ? 300 CYS A HA   1 
ATOM   4571 H HB2  . CYS A 1 300 ? -11.61213 -22.66090 37.84655  1.000 63.28654 ? 300 CYS A HB2  1 
ATOM   4572 H HB3  . CYS A 1 300 ? -10.36999 -22.25579 38.75120  1.000 63.28654 ? 300 CYS A HB3  1 
ATOM   4573 H HG   . CYS A 1 300 ? -10.86523 -20.24814 36.94820  1.000 56.55774 ? 300 CYS A HG   1 
ATOM   4574 N N    . SER A 1 301 ? -10.92840 -25.99907 38.35169  1.000 59.01384 ? 301 SER A N    1 
ATOM   4575 C CA   . SER A 1 301 ? -11.13015 -27.07754 39.31010  1.000 51.41908 ? 301 SER A CA   1 
ATOM   4576 C C    . SER A 1 301 ? -10.36283 -28.34876 38.96540  1.000 52.50326 ? 301 SER A C    1 
ATOM   4577 O O    . SER A 1 301 ? -10.36753 -29.28947 39.76731  1.000 53.37193 ? 301 SER A O    1 
ATOM   4578 C CB   . SER A 1 301 ? -12.62356 -27.42606 39.42199  1.000 47.54497 ? 301 SER A CB   1 
ATOM   4579 O OG   . SER A 1 301 ? -13.06399 -28.14620 38.28293  1.000 55.94534 ? 301 SER A OG   1 
ATOM   4580 H H    . SER A 1 301 ? -11.29225 -26.14795 37.58680  1.000 70.86690 ? 301 SER A H    1 
ATOM   4581 H HA   . SER A 1 301 ? -10.82695 -26.76806 40.17797  1.000 61.75319 ? 301 SER A HA   1 
ATOM   4582 H HB2  . SER A 1 301 ? -12.76156 -27.97129 40.21229  1.000 57.10426 ? 301 SER A HB2  1 
ATOM   4583 H HB3  . SER A 1 301 ? -13.13446 -26.60452 39.49237  1.000 57.10426 ? 301 SER A HB3  1 
ATOM   4584 H HG   . SER A 1 301 ? -13.60284 -27.67948 37.83862  1.000 67.18470 ? 301 SER A HG   1 
ATOM   4585 N N    . GLY A 1 302 ? -9.72546  -28.41284 37.79735  1.000 53.32016 ? 302 GLY A N    1 
ATOM   4586 C CA   . GLY A 1 302 ? -8.95299  -29.58127 37.42682  1.000 47.99411 ? 302 GLY A CA   1 
ATOM   4587 C C    . GLY A 1 302 ? -9.76470  -30.78631 37.01451  1.000 47.91909 ? 302 GLY A C    1 
ATOM   4588 O O    . GLY A 1 302 ? -9.30168  -31.92177 37.17956  1.000 39.77496 ? 302 GLY A O    1 
ATOM   4589 H H    . GLY A 1 302 ? -9.72810  -27.78932 37.20504  1.000 64.03449 ? 302 GLY A H    1 
ATOM   4590 H HA2  . GLY A 1 302 ? -8.37583  -29.34718 36.68318  1.000 57.64323 ? 302 GLY A HA2  1 
ATOM   4591 H HA3  . GLY A 1 302 ? -8.40395  -29.84140 38.18299  1.000 57.64323 ? 302 GLY A HA3  1 
ATOM   4592 N N    . VAL A 1 303 ? -10.97029 -30.57899 36.47626  1.000 51.34444 ? 303 VAL A N    1 
ATOM   4593 C CA   . VAL A 1 303 ? -11.81480 -31.69818 36.07848  1.000 52.02447 ? 303 VAL A CA   1 
ATOM   4594 C C    . VAL A 1 303 ? -11.07456 -32.59266 35.09517  1.000 48.48997 ? 303 VAL A C    1 
ATOM   4595 O O    . VAL A 1 303 ? -10.41514 -32.11594 34.16135  1.000 45.99823 ? 303 VAL A O    1 
ATOM   4596 C CB   . VAL A 1 303 ? -13.13097 -31.19643 35.45789  1.000 55.19233 ? 303 VAL A CB   1 
ATOM   4597 C CG1  . VAL A 1 303 ? -13.76915 -32.29392 34.59761  1.000 47.84236 ? 303 VAL A CG1  1 
ATOM   4598 C CG2  . VAL A 1 303 ? -14.09146 -30.72383 36.54314  1.000 50.63553 ? 303 VAL A CG2  1 
ATOM   4599 H H    . VAL A 1 303 ? -11.31667 -29.80491 36.33333  1.000 61.66362 ? 303 VAL A H    1 
ATOM   4600 H HA   . VAL A 1 303 ? -12.02264 -32.21350 36.87356  1.000 62.47965 ? 303 VAL A HA   1 
ATOM   4601 H HB   . VAL A 1 303 ? -12.93968 -30.43893 34.88301  1.000 66.28108 ? 303 VAL A HB   1 
ATOM   4602 H HG11 . VAL A 1 303 ? -14.68624 -32.04718 34.40019  1.000 57.46112 ? 303 VAL A HG11 1 
ATOM   4603 H HG12 . VAL A 1 303 ? -13.26551 -32.38191 33.77329  1.000 57.46112 ? 303 VAL A HG12 1 
ATOM   4604 H HG13 . VAL A 1 303 ? -13.74996 -33.13068 35.08788  1.000 57.46112 ? 303 VAL A HG13 1 
ATOM   4605 H HG21 . VAL A 1 303 ? -13.58401 -30.50362 37.33994  1.000 60.81293 ? 303 VAL A HG21 1 
ATOM   4606 H HG22 . VAL A 1 303 ? -14.56550 -29.93939 36.22556  1.000 60.81293 ? 303 VAL A HG22 1 
ATOM   4607 H HG23 . VAL A 1 303 ? -14.72184 -31.43474 36.73840  1.000 60.81293 ? 303 VAL A HG23 1 
ATOM   4608 N N    . THR A 1 304 ? -11.21116 -33.90040 35.28080  1.000 49.01686 ? 304 THR A N    1 
ATOM   4609 C CA   . THR A 1 304 ? -10.56324 -34.85122 34.39695  1.000 50.76528 ? 304 THR A CA   1 
ATOM   4610 C C    . THR A 1 304 ? -11.54617 -35.87037 33.81364  1.000 52.25076 ? 304 THR A C    1 
ATOM   4611 O O    . THR A 1 304 ? -12.74046 -35.83891 34.10638  1.000 53.48547 ? 304 THR A O    1 
ATOM   4612 C CB   . THR A 1 304 ? -9.44434  -35.60328 35.12905  1.000 46.50102 ? 304 THR A CB   1 
ATOM   4613 O OG1  . THR A 1 304 ? -8.40979  -34.70107 35.52853  1.000 38.94320 ? 304 THR A OG1  1 
ATOM   4614 C CG2  . THR A 1 304 ? -8.87188  -36.60778 34.21123  1.000 47.83539 ? 304 THR A CG2  1 
ATOM   4615 H H    . THR A 1 304 ? -11.67369 -34.25842 35.91126  1.000 58.87052 ? 304 THR A H    1 
ATOM   4616 H HA   . THR A 1 304 ? -10.18326 -34.36431 33.64899  1.000 60.96863 ? 304 THR A HA   1 
ATOM   4617 H HB   . THR A 1 304 ? -9.80035  -36.03428 35.92176  1.000 55.85151 ? 304 THR A HB   1 
ATOM   4618 H HG1  . THR A 1 304 ? -8.57536  -34.39437 36.29280  1.000 46.78213 ? 304 THR A HG1  1 
ATOM   4619 H HG21 . THR A 1 304 ? -7.93133  -36.73951 34.40846  1.000 57.45276 ? 304 THR A HG21 1 
ATOM   4620 H HG22 . THR A 1 304 ? -9.33634  -37.45322 34.31325  1.000 57.45276 ? 304 THR A HG22 1 
ATOM   4621 H HG23 . THR A 1 304 ? -8.96203  -36.30786 33.29318  1.000 57.45276 ? 304 THR A HG23 1 
HETATM 4622 C C7   . UED B 2 .   ? -14.42803 -22.43043 -0.22996  1.000 30.83847 ? 401 UED A C7   1 
HETATM 4623 O O8   . UED B 2 .   ? -15.05895 -23.63074 -0.67071  1.000 29.33442 ? 401 UED A O8   1 
HETATM 4624 C C9   . UED B 2 .   ? -15.26443 -24.62956 0.20815   1.000 26.17289 ? 401 UED A C9   1 
HETATM 4625 O O10  . UED B 2 .   ? -15.06950 -24.56399 1.42468   1.000 25.25936 ? 401 UED A O10  1 
HETATM 4626 C C1   . UED B 2 .   ? -12.91681 -22.57289 -0.31111  1.000 34.14188 ? 401 UED A C1   1 
HETATM 4627 C C2   . UED B 2 .   ? -12.36280 -23.67758 -0.96563  1.000 38.11121 ? 401 UED A C2   1 
HETATM 4628 C C3   . UED B 2 .   ? -10.97966 -23.82326 -1.05036  1.000 41.15677 ? 401 UED A C3   1 
HETATM 4629 C C4   . UED B 2 .   ? -10.14789 -22.86050 -0.48126  1.000 41.48356 ? 401 UED A C4   1 
HETATM 4630 C C5   . UED B 2 .   ? -10.69280 -21.75747 0.17477   1.000 37.69326 ? 401 UED A C5   1 
HETATM 4631 C C6   . UED B 2 .   ? -12.07640 -21.61198 0.26169   1.000 37.23949 ? 401 UED A C6   1 
HETATM 4632 N N11  . UED B 2 .   ? -15.71474 -25.76316 -0.43489  1.000 26.12964 ? 401 UED A N11  1 
HETATM 4633 C C12  . UED B 2 .   ? -15.78478 -26.99625 0.34368   1.000 25.81728 ? 401 UED A C12  1 
HETATM 4634 C C17  . UED B 2 .   ? -14.37476 -27.47154 0.70574   1.000 25.03221 ? 401 UED A C17  1 
HETATM 4635 O O18  . UED B 2 .   ? -13.46284 -27.39721 -0.11531  1.000 25.39286 ? 401 UED A O18  1 
HETATM 4636 C C13  . UED B 2 .   ? -16.50728 -28.07743 -0.46996  1.000 26.31907 ? 401 UED A C13  1 
HETATM 4637 C C14  . UED B 2 .   ? -17.89444 -27.62729 -0.99702  1.000 27.05986 ? 401 UED A C14  1 
HETATM 4638 C C15  . UED B 2 .   ? -18.77387 -27.00853 0.11305   1.000 25.35645 ? 401 UED A C15  1 
HETATM 4639 C C16  . UED B 2 .   ? -18.57076 -28.80341 -1.74293  1.000 28.83498 ? 401 UED A C16  1 
HETATM 4640 N N19  . UED B 2 .   ? -14.23684 -27.95467 1.93541   1.000 22.05531 ? 401 UED A N19  1 
HETATM 4641 C C20  . UED B 2 .   ? -12.96563 -28.45924 2.43258   1.000 22.84911 ? 401 UED A C20  1 
HETATM 4642 C C21  . UED B 2 .   ? -13.07320 -29.93784 2.82218   1.000 22.40614 ? 401 UED A C21  1 
HETATM 4643 O O22  . UED B 2 .   ? -11.76970 -30.48055 2.84922   1.000 30.10187 ? 401 UED A O22  1 
HETATM 4644 C C24  . UED B 2 .   ? -12.42425 -27.55872 3.56807   1.000 21.38379 ? 401 UED A C24  1 
HETATM 4645 C C25  . UED B 2 .   ? -12.17161 -26.05463 3.07403   1.000 22.99959 ? 401 UED A C25  1 
HETATM 4646 C C26  . UED B 2 .   ? -10.93674 -25.93470 2.17119   1.000 25.81873 ? 401 UED A C26  1 
HETATM 4647 C C27  . UED B 2 .   ? -10.15491 -24.76400 2.69153   1.000 27.62498 ? 401 UED A C27  1 
HETATM 4648 N N28  . UED B 2 .   ? -10.63814 -24.51006 4.03902   1.000 23.22526 ? 401 UED A N28  1 
HETATM 4649 C C29  . UED B 2 .   ? -11.82642 -25.26444 4.32038   1.000 22.22363 ? 401 UED A C29  1 
HETATM 4650 O O30  . UED B 2 .   ? -12.43011 -25.21885 5.38914   1.000 22.10573 ? 401 UED A O30  1 
HETATM 4651 H H1   . UED B 2 .   ? -14.71727 -22.20272 0.79812   1.000 37.05646 ? 401 UED A H1   1 
HETATM 4652 H H2   . UED B 2 .   ? -14.74710 -21.58460 -0.84252  1.000 37.05646 ? 401 UED A H2   1 
HETATM 4653 H H3   . UED B 2 .   ? -13.00551 -24.42482 -1.40961  1.000 45.78375 ? 401 UED A H3   1 
HETATM 4654 H H4   . UED B 2 .   ? -10.55230 -24.67851 -1.55482  1.000 49.43842 ? 401 UED A H4   1 
HETATM 4655 H H5   . UED B 2 .   ? -9.07546  -22.96899 -0.54852  1.000 49.83056 ? 401 UED A H5   1 
HETATM 4656 H H6   . UED B 2 .   ? -10.04361 -21.01443 0.61638   1.000 45.28220 ? 401 UED A H6   1 
HETATM 4657 H H7   . UED B 2 .   ? -12.49534 -20.75514 0.77260   1.000 44.73767 ? 401 UED A H7   1 
HETATM 4658 H H8   . UED B 2 .   ? -15.98723 -25.74628 -1.40833  1.000 31.40585 ? 401 UED A H8   1 
HETATM 4659 H H9   . UED B 2 .   ? -16.36817 -26.83017 1.25292   1.000 31.03102 ? 401 UED A H9   1 
HETATM 4660 H H10  . UED B 2 .   ? -16.62419 -28.97526 0.14232   1.000 31.63318 ? 401 UED A H10  1 
HETATM 4661 H H11  . UED B 2 .   ? -15.87853 -28.37955 -1.31141  1.000 31.63318 ? 401 UED A H11  1 
HETATM 4662 H H12  . UED B 2 .   ? -17.75983 -26.83879 -1.73893  1.000 32.52212 ? 401 UED A H12  1 
HETATM 4663 H H13  . UED B 2 .   ? -18.57994 -27.45859 1.08779   1.000 30.47803 ? 401 UED A H13  1 
HETATM 4664 H H14  . UED B 2 .   ? -19.83836 -27.13851 -0.08758  1.000 30.47803 ? 401 UED A H14  1 
HETATM 4665 H H15  . UED B 2 .   ? -18.60252 -25.93654 0.22150   1.000 30.47803 ? 401 UED A H15  1 
HETATM 4666 H H16  . UED B 2 .   ? -17.89510 -29.64196 -1.90493  1.000 34.65227 ? 401 UED A H16  1 
HETATM 4667 H H17  . UED B 2 .   ? -19.42703 -29.20579 -1.20366  1.000 34.65227 ? 401 UED A H17  1 
HETATM 4668 H H18  . UED B 2 .   ? -18.94043 -28.51941 -2.72711  1.000 34.65227 ? 401 UED A H18  1 
HETATM 4669 H H19  . UED B 2 .   ? -15.02994 -27.98056 2.56024   1.000 26.51666 ? 401 UED A H19  1 
HETATM 4670 H H20  . UED B 2 .   ? -12.23196 -28.46996 1.62248   1.000 27.46923 ? 401 UED A H20  1 
HETATM 4671 H H21  . UED B 2 .   ? -11.49874 -27.98858 3.95681   1.000 25.71084 ? 401 UED A H21  1 
HETATM 4672 H H22  . UED B 2 .   ? -13.12988 -27.56857 4.40141   1.000 25.71084 ? 401 UED A H22  1 
HETATM 4673 H H23  . UED B 2 .   ? -13.02351 -25.59448 2.57123   1.000 27.64980 ? 401 UED A H23  1 
HETATM 4674 H H24  . UED B 2 .   ? -11.20147 -25.76936 1.12684   1.000 31.03276 ? 401 UED A H24  1 
HETATM 4675 H H25  . UED B 2 .   ? -10.31896 -26.83247 2.19270   1.000 31.03276 ? 401 UED A H25  1 
HETATM 4676 H H26  . UED B 2 .   ? -10.30811 -23.87306 2.08255   1.000 33.20027 ? 401 UED A H26  1 
HETATM 4677 H H27  . UED B 2 .   ? -9.08638  -24.97610 2.72855   1.000 33.20027 ? 401 UED A H27  1 
HETATM 4678 H H28  . UED B 2 .   ? -9.96032  -24.33428 4.76686   1.000 27.92060 ? 401 UED A H28  1 
HETATM 4679 H H31  . UED B 2 .   ? -11.80870 -31.38172 2.52607   1.000 36.17254 ? 401 UED A H31  1 
HETATM 4680 O O    . HOH C 3 .   ? -26.43738 -17.52851 21.01440  1.000 37.93865 ? 501 HOH A O    1 
HETATM 4681 O O    . HOH C 3 .   ? -27.64895 -29.42146 22.57714  1.000 34.77817 ? 502 HOH A O    1 
HETATM 4682 O O    . HOH C 3 .   ? -25.56660 0.95209   33.78094  1.000 46.66936 ? 503 HOH A O    1 
HETATM 4683 O O    . HOH C 3 .   ? -29.48694 -13.53019 25.09736  1.000 42.09693 ? 504 HOH A O    1 
HETATM 4684 O O    . HOH C 3 .   ? -0.21044  -12.40126 25.96703  1.000 36.69978 ? 505 HOH A O    1 
HETATM 4685 O O    . HOH C 3 .   ? -21.48148 -14.69843 16.04004  1.000 25.66920 ? 506 HOH A O    1 
HETATM 4686 O O    . HOH C 3 .   ? -12.04350 -17.94383 3.01007   1.000 35.77448 ? 507 HOH A O    1 
HETATM 4687 O O    . HOH C 3 .   ? -17.47961 -32.10896 29.11628  1.000 45.38873 ? 508 HOH A O    1 
HETATM 4688 O O    . HOH C 3 .   ? -13.38429 -58.47551 4.72090   1.000 46.88512 ? 509 HOH A O    1 
HETATM 4689 O O    . HOH C 3 .   ? -32.12333 -32.84638 4.56446   1.000 40.99229 ? 510 HOH A O    1 
HETATM 4690 O O    . HOH C 3 .   ? -10.48294 -44.48642 20.01522  1.000 31.11448 ? 511 HOH A O    1 
HETATM 4691 O O    . HOH C 3 .   ? -20.33457 -14.25314 6.95752   1.000 43.73338 ? 512 HOH A O    1 
HETATM 4692 O O    . HOH C 3 .   ? -17.12590 -53.47507 -1.12661  1.000 31.81112 ? 513 HOH A O    1 
HETATM 4693 O O    . HOH C 3 .   ? -29.73514 -32.79410 13.64249  1.000 32.42118 ? 514 HOH A O    1 
HETATM 4694 O O    . HOH C 3 .   ? -11.29466 -35.24819 13.83424  1.000 24.28061 ? 515 HOH A O    1 
HETATM 4695 O O    . HOH C 3 .   ? -11.64439 -20.90064 20.84870  1.000 26.62210 ? 516 HOH A O    1 
HETATM 4696 O O    . HOH C 3 .   ? -13.65002 -44.60280 -6.31347  1.000 36.46652 ? 517 HOH A O    1 
HETATM 4697 O O    . HOH C 3 .   ? -26.69756 -28.36410 1.87844   1.000 26.43259 ? 518 HOH A O    1 
HETATM 4698 O O    . HOH C 3 .   ? -12.22431 -20.37423 17.77832  1.000 32.13588 ? 519 HOH A O    1 
HETATM 4699 O O    . HOH C 3 .   ? -15.02777 -37.66825 -5.96201  1.000 29.97816 ? 520 HOH A O    1 
HETATM 4700 O O    . HOH C 3 .   ? -20.28771 -7.76386  44.41606  1.000 34.25718 ? 521 HOH A O    1 
HETATM 4701 O O    . HOH C 3 .   ? -24.97851 -21.60190 24.90453  1.000 31.96328 ? 522 HOH A O    1 
HETATM 4702 O O    . HOH C 3 .   ? -6.31293  -25.04988 1.68487   1.000 33.32120 ? 523 HOH A O    1 
HETATM 4703 O O    . HOH C 3 .   ? -18.05133 -3.26336  41.18171  1.000 39.18091 ? 524 HOH A O    1 
HETATM 4704 O O    . HOH C 3 .   ? -19.08599 -37.74700 -8.89983  1.000 36.25444 ? 525 HOH A O    1 
HETATM 4705 O O    . HOH C 3 .   ? -25.71401 -13.14170 12.69478  1.000 36.90142 ? 526 HOH A O    1 
HETATM 4706 O O    . HOH C 3 .   ? -15.97895 -50.37794 21.90697  1.000 39.19106 ? 527 HOH A O    1 
HETATM 4707 O O    . HOH C 3 .   ? -25.91609 -28.10161 -1.41795  1.000 36.56419 ? 528 HOH A O    1 
HETATM 4708 O O    . HOH C 3 .   ? -21.93754 -45.96184 14.27707  1.000 28.10733 ? 529 HOH A O    1 
HETATM 4709 O O    . HOH C 3 .   ? -22.02346 -31.74977 -11.41147 1.000 40.28829 ? 530 HOH A O    1 
HETATM 4710 O O    . HOH C 3 .   ? -25.89538 -39.92370 11.52731  1.000 27.44218 ? 531 HOH A O    1 
HETATM 4711 O O    . HOH C 3 .   ? -14.34656 -50.08479 -1.07034  1.000 32.90674 ? 532 HOH A O    1 
HETATM 4712 O O    . HOH C 3 .   ? -22.78062 1.46152   35.97671  1.000 40.49141 ? 533 HOH A O    1 
HETATM 4713 O O    . HOH C 3 .   ? -4.06596  -22.56664 23.96866  1.000 24.69214 ? 534 HOH A O    1 
HETATM 4714 O O    . HOH C 3 .   ? -25.56088 -17.54271 10.54096  1.000 30.30565 ? 535 HOH A O    1 
HETATM 4715 O O    . HOH C 3 .   ? -33.83807 -12.61889 32.58803  1.000 36.65625 ? 536 HOH A O    1 
HETATM 4716 O O    . HOH C 3 .   ? -32.54240 -9.85911  30.01758  1.000 37.23079 ? 537 HOH A O    1 
HETATM 4717 O O    . HOH C 3 .   ? -11.98801 -49.65214 1.01120   1.000 29.46484 ? 538 HOH A O    1 
HETATM 4718 O O    . HOH C 3 .   ? -20.83405 -54.69355 9.52920   1.000 35.10577 ? 539 HOH A O    1 
HETATM 4719 O O    . HOH C 3 .   ? -28.45058 -3.68423  40.14269  1.000 27.73207 ? 540 HOH A O    1 
HETATM 4720 O O    . HOH C 3 .   ? -19.83210 -52.31099 -4.96447  1.000 27.04537 ? 541 HOH A O    1 
HETATM 4721 O O    . HOH C 3 .   ? -15.52275 -27.66248 25.46910  1.000 29.27485 ? 542 HOH A O    1 
HETATM 4722 O O    . HOH C 3 .   ? -25.36321 -46.54335 5.19015   1.000 31.51920 ? 543 HOH A O    1 
HETATM 4723 O O    . HOH C 3 .   ? -16.87273 -59.09128 4.56608   1.000 54.25584 ? 544 HOH A O    1 
HETATM 4724 O O    . HOH C 3 .   ? -33.97381 -7.96687  31.26548  1.000 42.27958 ? 545 HOH A O    1 
HETATM 4725 O O    . HOH C 3 .   ? -21.99156 -20.06548 26.90552  1.000 26.79654 ? 546 HOH A O    1 
HETATM 4726 O O    . HOH C 3 .   ? -27.81052 -25.49779 17.95744  1.000 35.16344 ? 547 HOH A O    1 
HETATM 4727 O O    . HOH C 3 .   ? -12.51801 -53.70842 21.28508  1.000 44.40756 ? 548 HOH A O    1 
HETATM 4728 O O    . HOH C 3 .   ? -26.13688 -20.08659 2.84942   1.000 33.75223 ? 549 HOH A O    1 
HETATM 4729 O O    . HOH C 3 .   ? -9.24788  0.61360   30.75075  1.000 52.30315 ? 550 HOH A O    1 
HETATM 4730 O O    . HOH C 3 .   ? -15.08723 -20.46882 17.10019  1.000 22.91413 ? 551 HOH A O    1 
HETATM 4731 O O    . HOH C 3 .   ? -27.68377 -33.91229 -12.43467 1.000 32.38697 ? 552 HOH A O    1 
HETATM 4732 O O    . HOH C 3 .   ? -29.96237 -10.18967 37.52757  1.000 33.72348 ? 553 HOH A O    1 
HETATM 4733 O O    . HOH C 3 .   ? -7.69331  -35.58614 3.57348   1.000 26.74261 ? 554 HOH A O    1 
HETATM 4734 O O    . HOH C 3 .   ? -6.652    -12.182   21.686    1.000 37.04831 ? 555 HOH A O    1 
HETATM 4735 O O    . HOH C 3 .   ? -11.62773 -17.92416 11.15300  1.000 27.28142 ? 556 HOH A O    1 
HETATM 4736 O O    . HOH C 3 .   ? -33.965   -11.391   36.820    1.000 36.91319 ? 557 HOH A O    1 
HETATM 4737 O O    . HOH C 3 .   ? -28.57946 -32.80826 20.29549  1.000 30.27187 ? 558 HOH A O    1 
HETATM 4738 O O    . HOH C 3 .   ? -26.78531 -5.37332  18.53352  1.000 39.42377 ? 559 HOH A O    1 
HETATM 4739 O O    . HOH C 3 .   ? -4.60323  -25.14470 8.94401   1.000 33.38184 ? 560 HOH A O    1 
HETATM 4740 O O    . HOH C 3 .   ? -26.30491 -4.65540  41.56417  1.000 29.38226 ? 561 HOH A O    1 
HETATM 4741 O O    . HOH C 3 .   ? -30.47453 -17.28630 28.47918  1.000 40.60307 ? 562 HOH A O    1 
HETATM 4742 O O    . HOH C 3 .   ? -20.12212 0.79756   34.62392  1.000 38.74566 ? 563 HOH A O    1 
HETATM 4743 O O    . HOH C 3 .   ? -13.62435 -55.36413 15.55124  1.000 40.52100 ? 564 HOH A O    1 
HETATM 4744 O O    . HOH C 3 .   ? -24.60102 -12.06304 41.17388  1.000 37.61338 ? 565 HOH A O    1 
HETATM 4745 O O    . HOH C 3 .   ? -31.192   -21.107   36.738    1.000 37.65429 ? 566 HOH A O    1 
HETATM 4746 O O    . HOH C 3 .   ? -12.08803 -21.98711 23.77634  1.000 33.31589 ? 567 HOH A O    1 
HETATM 4747 O O    . HOH C 3 .   ? -9.289    -17.724   8.135     1.000 35.91123 ? 568 HOH A O    1 
HETATM 4748 O O    . HOH C 3 .   ? -32.34565 -3.26780  27.73164  1.000 42.65211 ? 569 HOH A O    1 
HETATM 4749 O O    . HOH C 3 .   ? -14.60732 -13.25698 19.81543  1.000 33.07414 ? 570 HOH A O    1 
HETATM 4750 O O    . HOH C 3 .   ? -2.59313  -10.28558 31.48362  1.000 38.66187 ? 571 HOH A O    1 
HETATM 4751 O O    . HOH C 3 .   ? -21.806   1.884     43.293    1.000 38.23222 ? 572 HOH A O    1 
HETATM 4752 O O    . HOH C 3 .   ? -14.78079 -16.20911 27.18304  1.000 23.40493 ? 573 HOH A O    1 
HETATM 4753 O O    . HOH C 3 .   ? -28.41297 -24.99605 6.71350   1.000 31.95748 ? 574 HOH A O    1 
HETATM 4754 O O    . HOH C 3 .   ? -28.50529 -23.67778 12.85092  1.000 30.42433 ? 575 HOH A O    1 
HETATM 4755 O O    . HOH C 3 .   ? -3.08839  -22.36040 41.78468  1.000 30.19408 ? 576 HOH A O    1 
HETATM 4756 O O    . HOH C 3 .   ? -15.12161 -44.56433 26.24110  1.000 39.80937 ? 577 HOH A O    1 
HETATM 4757 O O    . HOH C 3 .   ? -29.57553 -27.02871 9.25088   1.000 34.30452 ? 578 HOH A O    1 
HETATM 4758 O O    . HOH C 3 .   ? -28.97349 -42.67017 0.44929   1.000 30.33116 ? 579 HOH A O    1 
HETATM 4759 O O    . HOH C 3 .   ? -27.91329 -27.23524 4.39750   1.000 24.80078 ? 580 HOH A O    1 
HETATM 4760 O O    . HOH C 3 .   ? -8.935    -38.930   24.888    1.000 31.87511 ? 581 HOH A O    1 
HETATM 4761 O O    . HOH C 3 .   ? -7.86391  5.45303   25.85867  1.000 47.95777 ? 582 HOH A O    1 
HETATM 4762 O O    . HOH C 3 .   ? -16.17858 -38.59773 -8.22362  1.000 33.80580 ? 583 HOH A O    1 
HETATM 4763 O O    . HOH C 3 .   ? -18.33770 -15.39561 11.81273  1.000 26.18025 ? 584 HOH A O    1 
HETATM 4764 O O    . HOH C 3 .   ? -5.49760  -27.85591 10.30500  1.000 26.56273 ? 585 HOH A O    1 
HETATM 4765 O O    . HOH C 3 .   ? -21.61172 -24.09338 10.48568  1.000 22.18841 ? 586 HOH A O    1 
HETATM 4766 O O    . HOH C 3 .   ? -31.41032 -37.27673 4.42773   1.000 32.67656 ? 587 HOH A O    1 
HETATM 4767 O O    . HOH C 3 .   ? -24.26472 -34.55317 16.20742  1.000 23.79474 ? 588 HOH A O    1 
HETATM 4768 O O    . HOH C 3 .   ? -9.42234  -18.76503 12.66151  1.000 28.79671 ? 589 HOH A O    1 
HETATM 4769 O O    . HOH C 3 .   ? -29.54350 -35.43117 1.74590   1.000 24.72346 ? 590 HOH A O    1 
HETATM 4770 O O    . HOH C 3 .   ? -25.84730 -44.91725 -4.81252  1.000 27.10629 ? 591 HOH A O    1 
HETATM 4771 O O    . HOH C 3 .   ? -19.24148 -14.76846 4.37201   1.000 36.11637 ? 592 HOH A O    1 
HETATM 4772 O O    . HOH C 3 .   ? -14.04709 1.38059   23.25048  1.000 41.53045 ? 593 HOH A O    1 
HETATM 4773 O O    . HOH C 3 .   ? -13.95510 -26.67728 -6.55879  1.000 44.52989 ? 594 HOH A O    1 
HETATM 4774 O O    . HOH C 3 .   ? -7.19901  -14.72111 27.77411  1.000 35.40952 ? 595 HOH A O    1 
HETATM 4775 O O    . HOH C 3 .   ? -30.25912 -21.79846 3.55930   1.000 33.60270 ? 596 HOH A O    1 
HETATM 4776 O O    . HOH C 3 .   ? -28.79324 -40.67093 -4.56854  1.000 34.10915 ? 597 HOH A O    1 
HETATM 4777 O O    . HOH C 3 .   ? -3.02738  -7.56488  33.74633  1.000 42.37809 ? 598 HOH A O    1 
HETATM 4778 O O    . HOH C 3 .   ? -19.43930 -26.86262 25.60871  1.000 29.15968 ? 599 HOH A O    1 
HETATM 4779 O O    . HOH C 3 .   ? -5.000    -22.707   36.897    1.000 36.60930 ? 600 HOH A O    1 
HETATM 4780 O O    . HOH C 3 .   ? -29.68826 -40.29172 12.70459  1.000 41.02538 ? 601 HOH A O    1 
HETATM 4781 O O    . HOH C 3 .   ? -13.08265 -23.48504 25.80424  1.000 31.29376 ? 602 HOH A O    1 
HETATM 4782 O O    . HOH C 3 .   ? -12.94317 -51.03349 -3.77584  1.000 30.22138 ? 603 HOH A O    1 
HETATM 4783 O O    . HOH C 3 .   ? -12.36595 -34.86539 37.66302  1.000 42.50326 ? 604 HOH A O    1 
HETATM 4784 O O    . HOH C 3 .   ? -8.96728  -44.01514 1.26909   1.000 26.98431 ? 605 HOH A O    1 
HETATM 4785 O O    . HOH C 3 .   ? -26.44109 -17.63097 4.48613   1.000 32.52779 ? 606 HOH A O    1 
HETATM 4786 O O    . HOH C 3 .   ? -7.46509  -46.33490 0.20829   1.000 37.09444 ? 607 HOH A O    1 
HETATM 4787 O O    . HOH C 3 .   ? -28.09931 -37.43535 26.83187  1.000 47.20782 ? 608 HOH A O    1 
HETATM 4788 O O    . HOH C 3 .   ? -32.00790 -37.44442 9.89660   1.000 31.83945 ? 609 HOH A O    1 
HETATM 4789 O O    . HOH C 3 .   ? -6.30363  -43.67563 9.07477   1.000 32.56435 ? 610 HOH A O    1 
HETATM 4790 O O    . HOH C 3 .   ? -21.03590 -39.02529 -9.65671  1.000 35.82760 ? 611 HOH A O    1 
HETATM 4791 O O    . HOH C 3 .   ? -0.12871  -3.47221  25.73665  1.000 44.16067 ? 612 HOH A O    1 
HETATM 4792 O O    . HOH C 3 .   ? -20.206   -0.787    17.973    1.000 41.88786 ? 613 HOH A O    1 
HETATM 4793 O O    . HOH C 3 .   ? -20.62205 -32.03869 2.15679   1.000 19.36939 ? 614 HOH A O    1 
HETATM 4794 O O    . HOH C 3 .   ? -18.59831 -51.73088 18.36123  1.000 37.90035 ? 615 HOH A O    1 
HETATM 4795 O O    . HOH C 3 .   ? -18.31927 -25.99119 27.95344  1.000 34.09774 ? 616 HOH A O    1 
HETATM 4796 O O    . HOH C 3 .   ? -27.58706 -17.68339 18.06307  1.000 35.02799 ? 617 HOH A O    1 
HETATM 4797 O O    . HOH C 3 .   ? -2.72247  -12.89943 33.94630  1.000 40.89025 ? 618 HOH A O    1 
HETATM 4798 O O    . HOH C 3 .   ? -28.18725 -31.80074 -4.18132  1.000 30.52806 ? 619 HOH A O    1 
HETATM 4799 O O    . HOH C 3 .   ? -15.37557 -6.79948  22.66287  1.000 29.46870 ? 620 HOH A O    1 
HETATM 4800 O O    . HOH C 3 .   ? -24.61943 -14.22273 26.56467  1.000 30.73691 ? 621 HOH A O    1 
HETATM 4801 O O    . HOH C 3 .   ? -18.10968 -14.06195 9.33004   1.000 37.96486 ? 622 HOH A O    1 
HETATM 4802 O O    . HOH C 3 .   ? -4.65366  -19.71361 25.64411  1.000 27.89934 ? 623 HOH A O    1 
HETATM 4803 O O    . HOH C 3 .   ? -20.23699 -32.05099 22.24946  1.000 27.56354 ? 624 HOH A O    1 
HETATM 4804 O O    . HOH C 3 .   ? -16.43643 -4.27568  39.61894  1.000 38.27805 ? 625 HOH A O    1 
HETATM 4805 O O    . HOH C 3 .   ? -20.09467 -8.97661  12.16051  1.000 38.01620 ? 626 HOH A O    1 
HETATM 4806 O O    . HOH C 3 .   ? -17.88177 -4.99473  19.87030  1.000 38.69950 ? 627 HOH A O    1 
HETATM 4807 O O    . HOH C 3 .   ? -15.42057 -1.86410  22.76296  1.000 38.78914 ? 628 HOH A O    1 
HETATM 4808 O O    . HOH C 3 .   ? -22.83615 -21.98802 28.96229  1.000 33.31203 ? 629 HOH A O    1 
HETATM 4809 O O    . HOH C 3 .   ? -28.31898 -28.88453 6.58610   1.000 24.18562 ? 630 HOH A O    1 
HETATM 4810 O O    . HOH C 3 .   ? -4.42362  -42.49446 7.69682   1.000 37.12425 ? 631 HOH A O    1 
HETATM 4811 O O    . HOH C 3 .   ? -4.92539  -17.97488 41.23586  1.000 41.52145 ? 632 HOH A O    1 
HETATM 4812 O O    . HOH C 3 .   ? 0.64509   -1.58019  36.46766  1.000 38.58396 ? 633 HOH A O    1 
HETATM 4813 O O    . HOH C 3 .   ? -11.23567 -24.90959 30.04140  1.000 35.29313 ? 634 HOH A O    1 
HETATM 4814 O O    . HOH C 3 .   ? -21.09604 -54.37281 -1.90308  1.000 30.88009 ? 635 HOH A O    1 
HETATM 4815 O O    . HOH C 3 .   ? -10.51012 -24.20058 27.18630  1.000 28.02028 ? 636 HOH A O    1 
HETATM 4816 O O    . HOH C 3 .   ? -9.17932  -49.02815 14.89108  1.000 31.48994 ? 637 HOH A O    1 
HETATM 4817 O O    . HOH C 3 .   ? -25.26975 4.45939   31.11487  1.000 46.38864 ? 638 HOH A O    1 
HETATM 4818 O O    . HOH C 3 .   ? -16.37320 -51.88556 19.22672  1.000 36.54836 ? 639 HOH A O    1 
HETATM 4819 O O    . HOH C 3 .   ? -11.35984 -32.84916 -9.18704  1.000 58.18688 ? 640 HOH A O    1 
HETATM 4820 O O    . HOH C 3 .   ? -31.23528 -6.16139  36.80819  1.000 36.56275 ? 641 HOH A O    1 
HETATM 4821 O O    . HOH C 3 .   ? -21.25936 -23.24608 30.66709  1.000 29.95263 ? 642 HOH A O    1 
HETATM 4822 O O    . HOH C 3 .   ? -7.20615  -34.36520 0.69030   1.000 35.98458 ? 643 HOH A O    1 
HETATM 4823 O O    . HOH C 3 .   ? -7.13209  -24.71213 22.01896  1.000 21.53749 ? 644 HOH A O    1 
HETATM 4824 O O    . HOH C 3 .   ? -32.23361 -34.82668 10.68094  1.000 36.16955 ? 645 HOH A O    1 
HETATM 4825 O O    . HOH C 3 .   ? -23.07783 -3.99631  13.14738  1.000 45.03355 ? 646 HOH A O    1 
HETATM 4826 O O    . HOH C 3 .   ? -0.21594  -29.69684 15.86566  1.000 33.58513 ? 647 HOH A O    1 
HETATM 4827 O O    . HOH C 3 .   ? -23.30720 -50.49524 -4.12722  1.000 26.34174 ? 648 HOH A O    1 
HETATM 4828 O O    . HOH C 3 .   ? -2.74470  -17.27421 32.44210  1.000 30.22961 ? 649 HOH A O    1 
HETATM 4829 O O    . HOH C 3 .   ? -24.19814 -32.54701 -10.18036 1.000 31.08495 ? 650 HOH A O    1 
HETATM 4830 O O    . HOH C 3 .   ? -12.71419 -6.65778  22.67550  1.000 30.86793 ? 651 HOH A O    1 
HETATM 4831 O O    . HOH C 3 .   ? -17.71827 -29.72496 28.03830  1.000 42.23401 ? 652 HOH A O    1 
HETATM 4832 O O    . HOH C 3 .   ? -19.65411 -11.88374 9.60666   1.000 37.73663 ? 653 HOH A O    1 
HETATM 4833 O O    . HOH C 3 .   ? -21.54968 -45.72088 23.10230  1.000 35.06506 ? 654 HOH A O    1 
HETATM 4834 O O    . HOH C 3 .   ? -11.79233 -42.02433 30.61168  1.000 43.75596 ? 655 HOH A O    1 
HETATM 4835 O O    . HOH C 3 .   ? -26.53109 -39.11422 -12.50151 1.000 42.10636 ? 656 HOH A O    1 
HETATM 4836 O O    . HOH C 3 .   ? -23.00241 -22.29764 -8.99116  1.000 43.21814 ? 657 HOH A O    1 
HETATM 4837 O O    . HOH C 3 .   ? -23.64838 -11.24446 6.50277   1.000 46.94744 ? 658 HOH A O    1 
HETATM 4838 O O    . HOH C 3 .   ? -24.04136 -54.54039 12.85935  1.000 40.93423 ? 659 HOH A O    1 
HETATM 4839 O O    . HOH C 3 .   ? -26.42761 -40.54420 19.93086  1.000 33.56892 ? 660 HOH A O    1 
HETATM 4840 O O    . HOH C 3 .   ? -13.51565 -46.98832 -7.83090  1.000 45.32099 ? 661 HOH A O    1 
HETATM 4841 O O    . HOH C 3 .   ? -25.04601 -27.64798 23.87154  1.000 34.95936 ? 662 HOH A O    1 
HETATM 4842 O O    . HOH C 3 .   ? -7.296    -27.916   34.385    1.000 41.91403 ? 663 HOH A O    1 
HETATM 4843 O O    . HOH C 3 .   ? -22.84096 -14.29025 44.54859  1.000 40.06511 ? 664 HOH A O    1 
HETATM 4844 O O    . HOH C 3 .   ? -35.44014 -1.51559  33.72481  1.000 44.87112 ? 665 HOH A O    1 
HETATM 4845 O O    . HOH C 3 .   ? -25.37645 -51.95156 -0.63934  1.000 34.77374 ? 666 HOH A O    1 
HETATM 4846 O O    . HOH C 3 .   ? -33.07314 -33.26030 9.03314   1.000 40.20516 ? 667 HOH A O    1 
HETATM 4847 O O    . HOH C 3 .   ? -29.622   -21.019   34.080    1.000 35.90721 ? 668 HOH A O    1 
HETATM 4848 O O    . HOH C 3 .   ? -3.41499  -30.16424 3.35776   1.000 41.85260 ? 669 HOH A O    1 
HETATM 4849 O O    . HOH C 3 .   ? -33.205   -4.443    34.535    1.000 37.36480 ? 670 HOH A O    1 
HETATM 4850 O O    . HOH C 3 .   ? -29.43504 -24.94919 15.46660  1.000 36.75764 ? 671 HOH A O    1 
HETATM 4851 O O    . HOH C 3 .   ? -5.06444  -10.11434 22.23195  0.50  25.32538 ? 672 HOH A O    1 
HETATM 4852 O O    . HOH C 3 .   ? -29.36867 -12.72838 40.58566  1.000 36.05799 ? 673 HOH A O    1 
HETATM 4853 O O    . HOH C 3 .   ? -5.06444  -26.78127 22.23195  0.50  26.65459 ? 674 HOH A O    1 
HETATM 4854 O O    . HOH C 3 .   ? -14.98980 -52.24951 -0.43004  1.000 29.50749 ? 675 HOH A O    1 
HETATM 4855 O O    . HOH C 3 .   ? -1.586    1.514     30.627    1.000 46.90228 ? 676 HOH A O    1 
HETATM 4856 O O    . HOH C 3 .   ? -17.32720 -20.38067 -1.59221  1.000 45.26182 ? 677 HOH A O    1 
HETATM 4857 O O    . HOH C 3 .   ? -3.89425  -49.65164 1.19976   1.000 43.71870 ? 678 HOH A O    1 
HETATM 4858 O O    . HOH C 3 .   ? -25.91683 -9.64554  40.57431  1.000 32.35466 ? 679 HOH A O    1 
HETATM 4859 O O    . HOH C 3 .   ? -16.78230 -56.41638 -0.67935  1.000 32.83413 ? 680 HOH A O    1 
HETATM 4860 O O    . HOH C 3 .   ? -29.23724 -46.81073 0.13346   1.000 40.47906 ? 681 HOH A O    1 
HETATM 4861 O O    . HOH C 3 .   ? -29.00085 -38.03226 -13.10889 1.000 36.93313 ? 682 HOH A O    1 
HETATM 4862 O O    . HOH C 3 .   ? -29.12833 -30.37405 -1.50257  1.000 39.21976 ? 683 HOH A O    1 
HETATM 4863 O O    . HOH C 3 .   ? -25.96496 -49.17649 4.27018   1.000 40.33600 ? 684 HOH A O    1 
HETATM 4864 O O    . HOH C 3 .   ? -30.17715 -16.34214 25.99086  1.000 40.21768 ? 685 HOH A O    1 
HETATM 4865 O O    . HOH C 3 .   ? -12.29255 -44.51253 29.79774  1.000 45.98383 ? 686 HOH A O    1 
HETATM 4866 O O    . HOH C 3 .   ? -16.02290 -5.24875  41.76190  1.000 40.65150 ? 687 HOH A O    1 
HETATM 4867 O O    . HOH C 3 .   ? -12.26605 -54.17813 -0.04920  1.000 36.53775 ? 688 HOH A O    1 
HETATM 4868 O O    . HOH C 3 .   ? -29.31697 -26.09485 -1.65056  1.000 38.76027 ? 689 HOH A O    1 
HETATM 4869 O O    . HOH C 3 .   ? -27.35461 -44.01467 -1.72105  1.000 28.28369 ? 690 HOH A O    1 
HETATM 4870 O O    . HOH C 3 .   ? -26.92954 -23.52371 25.85534  1.000 40.62615 ? 691 HOH A O    1 
HETATM 4871 O O    . HOH C 3 .   ? -15.341   -60.869   0.378     1.000 35.25227 ? 692 HOH A O    1 
HETATM 4872 O O    . HOH C 3 .   ? -0.115    -0.324    31.587    1.000 35.40785 ? 693 HOH A O    1 
HETATM 4873 O O    . HOH C 3 .   ? -25.64121 -50.60492 -2.41479  1.000 28.83214 ? 694 HOH A O    1 
HETATM 4874 O O    . HOH C 3 .   ? -28.25255 -28.03152 -0.39266  1.000 37.37958 ? 695 HOH A O    1 
HETATM 4875 O O    . HOH C 3 .   ? -21.73672 -31.86931 24.44255  1.000 33.87715 ? 696 HOH A O    1 
HETATM 4876 O O    . HOH C 3 .   ? -27.95230 -43.32592 -4.27397  1.000 28.85421 ? 697 HOH A O    1 
HETATM 4877 O O    . HOH C 3 .   ? -28.72434 -18.11853 22.03127  1.000 42.30880 ? 698 HOH A O    1 
HETATM 4878 O O    . HOH C 3 .   ? -18.784   -54.257   -3.336    1.000 29.91713 ? 699 HOH A O    1 
HETATM 4879 O O    . HOH C 3 .   ? -9.25705  -17.36400 14.75895  1.000 33.43956 ? 700 HOH A O    1 
HETATM 4880 O O    . HOH C 3 .   ? -26.91424 -41.34992 13.48664  1.000 33.29965 ? 701 HOH A O    1 
HETATM 4881 O O    . HOH C 3 .   ? -24.51232 -19.31832 26.23777  1.000 34.32634 ? 702 HOH A O    1 
HETATM 4882 O O    . HOH C 3 .   ? -26.11280 -20.35380 28.52979  1.000 42.59364 ? 703 HOH A O    1 
HETATM 4883 O O    . HOH C 3 .   ? -27.74995 -18.13958 12.07528  1.000 34.12607 ? 704 HOH A O    1 
HETATM 4884 O O    . HOH C 3 .   ? -22.71019 -52.63721 -5.47939  1.000 33.74618 ? 705 HOH A O    1 
HETATM 4885 O O    . HOH C 3 .   ? -13.32176 -11.97234 13.95090  1.000 42.99722 ? 706 HOH A O    1 
HETATM 4886 O O    . HOH C 3 .   ? -16.225   -60.492   -2.159    1.000 30.11444 ? 707 HOH A O    1 
HETATM 4887 O O    . HOH C 3 .   ? -14.55035 -38.84727 -10.39802 1.000 50.02952 ? 708 HOH A O    1 
HETATM 4888 O O    . HOH C 3 .   ? -18.241   -2.696    17.890    1.000 38.43590 ? 709 HOH A O    1 
HETATM 4889 O O    . HOH C 3 .   ? -25.31818 -34.40116 -11.72323 1.000 35.13788 ? 710 HOH A O    1 
HETATM 4890 O O    . HOH C 3 .   ? -11.88637 -4.28802  23.64549  1.000 39.95544 ? 711 HOH A O    1 
HETATM 4891 O O    . HOH C 3 .   ? -16.12332 -54.14224 19.29394  1.000 50.68379 ? 712 HOH A O    1 
HETATM 4892 O O    . HOH C 3 .   ? -30.32341 -26.56763 3.86694   1.000 36.76696 ? 713 HOH A O    1 
HETATM 4893 O O    . HOH C 3 .   ? -18.93887 -12.57983 3.06164   1.000 49.05702 ? 714 HOH A O    1 
HETATM 4894 O O    . HOH C 3 .   ? -28.41851 -10.27305 39.86755  1.000 34.36131 ? 715 HOH A O    1 
HETATM 4895 O O    . HOH C 3 .   ? -18.29408 -57.88906 0.74204   1.000 39.88863 ? 716 HOH A O    1 
HETATM 4896 O O    . HOH C 3 .   ? -13.87710 -13.58920 11.96209  1.000 35.61645 ? 717 HOH A O    1 
HETATM 4897 O O    . HOH C 3 .   ? -11.79349 -15.11609 11.86252  1.000 37.60220 ? 718 HOH A O    1 
HETATM 4898 O O    . HOH C 3 .   ? -29.60618 -19.20914 17.76947  1.000 39.79985 ? 719 HOH A O    1 
HETATM 4899 O O    . HOH C 3 .   ? -5.06444  -20.49102 22.23195  0.50  23.62319 ? 720 HOH A O    1 
HETATM 4900 O O    . HOH C 3 .   ? -29.80427 -21.90874 30.00443  1.000 41.40748 ? 721 HOH A O    1 
HETATM 4901 O O    . HOH C 3 .   ? -27.74832 -41.29500 17.85450  1.000 46.33568 ? 722 HOH A O    1 
HETATM 4902 O O    . HOH C 3 .   ? -16.06289 -4.46640  21.24472  1.000 38.59903 ? 723 HOH A O    1 
HETATM 4903 O O    . HOH C 3 .   ? -26.44092 -41.01440 -14.09929 1.000 43.96216 ? 724 HOH A O    1 
HETATM 4904 O O    . HOH C 3 .   ? -29.27159 -23.01050 32.31336  1.000 38.66544 ? 725 HOH A O    1 
HETATM 4905 O O    . HOH C 3 .   ? -15.846   -10.715   0.574     1.000 42.77811 ? 726 HOH A O    1 
HETATM 4906 O O    . HOH C 3 .   ? -19.02858 -12.52010 0.17049   1.000 41.42834 ? 727 HOH A O    1 
HETATM 4907 O O    . HOH C 3 .   ? -27.86661 -13.52317 42.85100  1.000 38.73274 ? 728 HOH A O    1 
HETATM 4908 O O    . HOH C 3 .   ? -27.30455 -33.23893 25.11781  1.000 48.68374 ? 729 HOH A O    1 
HETATM 4909 O O    . HOH C 3 .   ? -29.26439 -8.36400  41.90428  1.000 50.01006 ? 730 HOH A O    1 
# 
