data_9BOB
# 
_entry.id   9BOB 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BOB         pdb_00009bob 10.2210/pdb9bob/pdb 
WWPDB D_1000283413 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-12 ? 
2 'Structure model' 1 1 2025-03-12 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
_pdbx_audit_revision_category.ordinal             1 
_pdbx_audit_revision_category.revision_ordinal    2 
_pdbx_audit_revision_category.data_content_type   'Structure model' 
_pdbx_audit_revision_category.category            citation 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
5 2 'Structure model' '_citation.title'                   
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BOB 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-03 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              karen.anderson@yale.edu 
_pdbx_contact_author.name_first         Karen 
_pdbx_contact_author.name_last          Anderson 
_pdbx_contact_author.name_mi            S 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-3433-0780 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Papini, C.'     1 0000-0002-6098-4959 
'Kenneson, J.'   2 ?                   
'Anderson, K.S.' 3 0000-0003-3433-0780 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Acs Bio Med Chem Au' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2694-2437 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            5 
_citation.language                  ? 
_citation.page_first                215 
_citation.page_last                 226 
_citation.title                     
'Exploring Possible Drug-Resistant Variants of SARS-CoV-2 Main Protease (M pro ) with Noncovalent Preclinical Candidate, Mpro61.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acsbiomedchemau.4c00109 
_citation.pdbx_database_id_PubMed   39990941 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Kenneson, J.R.'  1 ? 
primary 'Papini, C.'      2 ? 
primary 'Tang, S.'        3 ? 
primary 'Huynh, K.'       4 ? 
primary 'Zhang, C.H.'     5 ? 
primary 'Jorgensen, W.L.' 6 ? 
primary 'Anderson, K.S.'  7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '3C-like proteinase nsp5'                                                                              33887.613 
1   3.4.22.69 ? ? ? 
2 non-polymer syn 'N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide' 405.488   
1   ?         ? ? ? 
3 water       nat water                                                                                                  18.015    
159 ?         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMFNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHVGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMFNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHVGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide' UED 
3 water                                                                                                  HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   GLY n 
1 3   PHE n 
1 4   ARG n 
1 5   LYS n 
1 6   MET n 
1 7   ALA n 
1 8   PHE n 
1 9   PRO n 
1 10  SER n 
1 11  GLY n 
1 12  LYS n 
1 13  VAL n 
1 14  GLU n 
1 15  GLY n 
1 16  CYS n 
1 17  MET n 
1 18  VAL n 
1 19  GLN n 
1 20  VAL n 
1 21  THR n 
1 22  CYS n 
1 23  GLY n 
1 24  THR n 
1 25  THR n 
1 26  THR n 
1 27  LEU n 
1 28  ASN n 
1 29  GLY n 
1 30  LEU n 
1 31  TRP n 
1 32  LEU n 
1 33  ASP n 
1 34  ASP n 
1 35  VAL n 
1 36  VAL n 
1 37  TYR n 
1 38  CYS n 
1 39  PRO n 
1 40  ARG n 
1 41  HIS n 
1 42  VAL n 
1 43  ILE n 
1 44  CYS n 
1 45  THR n 
1 46  SER n 
1 47  GLU n 
1 48  ASP n 
1 49  MET n 
1 50  PHE n 
1 51  ASN n 
1 52  PRO n 
1 53  ASN n 
1 54  TYR n 
1 55  GLU n 
1 56  ASP n 
1 57  LEU n 
1 58  LEU n 
1 59  ILE n 
1 60  ARG n 
1 61  LYS n 
1 62  SER n 
1 63  ASN n 
1 64  HIS n 
1 65  ASN n 
1 66  PHE n 
1 67  LEU n 
1 68  VAL n 
1 69  GLN n 
1 70  ALA n 
1 71  GLY n 
1 72  ASN n 
1 73  VAL n 
1 74  GLN n 
1 75  LEU n 
1 76  ARG n 
1 77  VAL n 
1 78  ILE n 
1 79  GLY n 
1 80  HIS n 
1 81  SER n 
1 82  MET n 
1 83  GLN n 
1 84  ASN n 
1 85  CYS n 
1 86  VAL n 
1 87  LEU n 
1 88  LYS n 
1 89  LEU n 
1 90  LYS n 
1 91  VAL n 
1 92  ASP n 
1 93  THR n 
1 94  ALA n 
1 95  ASN n 
1 96  PRO n 
1 97  LYS n 
1 98  THR n 
1 99  PRO n 
1 100 LYS n 
1 101 TYR n 
1 102 LYS n 
1 103 PHE n 
1 104 VAL n 
1 105 ARG n 
1 106 ILE n 
1 107 GLN n 
1 108 PRO n 
1 109 GLY n 
1 110 GLN n 
1 111 THR n 
1 112 PHE n 
1 113 SER n 
1 114 VAL n 
1 115 LEU n 
1 116 ALA n 
1 117 CYS n 
1 118 TYR n 
1 119 ASN n 
1 120 GLY n 
1 121 SER n 
1 122 PRO n 
1 123 SER n 
1 124 GLY n 
1 125 VAL n 
1 126 TYR n 
1 127 GLN n 
1 128 CYS n 
1 129 ALA n 
1 130 MET n 
1 131 ARG n 
1 132 PRO n 
1 133 ASN n 
1 134 PHE n 
1 135 THR n 
1 136 ILE n 
1 137 LYS n 
1 138 GLY n 
1 139 SER n 
1 140 PHE n 
1 141 LEU n 
1 142 ASN n 
1 143 GLY n 
1 144 SER n 
1 145 CYS n 
1 146 GLY n 
1 147 SER n 
1 148 VAL n 
1 149 GLY n 
1 150 PHE n 
1 151 ASN n 
1 152 ILE n 
1 153 ASP n 
1 154 TYR n 
1 155 ASP n 
1 156 CYS n 
1 157 VAL n 
1 158 SER n 
1 159 PHE n 
1 160 CYS n 
1 161 TYR n 
1 162 MET n 
1 163 HIS n 
1 164 HIS n 
1 165 MET n 
1 166 GLU n 
1 167 LEU n 
1 168 PRO n 
1 169 THR n 
1 170 GLY n 
1 171 VAL n 
1 172 HIS n 
1 173 VAL n 
1 174 GLY n 
1 175 THR n 
1 176 ASP n 
1 177 LEU n 
1 178 GLU n 
1 179 GLY n 
1 180 ASN n 
1 181 PHE n 
1 182 TYR n 
1 183 GLY n 
1 184 PRO n 
1 185 PHE n 
1 186 VAL n 
1 187 ASP n 
1 188 ARG n 
1 189 GLN n 
1 190 THR n 
1 191 ALA n 
1 192 GLN n 
1 193 ALA n 
1 194 ALA n 
1 195 GLY n 
1 196 THR n 
1 197 ASP n 
1 198 THR n 
1 199 THR n 
1 200 ILE n 
1 201 THR n 
1 202 VAL n 
1 203 ASN n 
1 204 VAL n 
1 205 LEU n 
1 206 ALA n 
1 207 TRP n 
1 208 LEU n 
1 209 TYR n 
1 210 ALA n 
1 211 ALA n 
1 212 VAL n 
1 213 ILE n 
1 214 ASN n 
1 215 GLY n 
1 216 ASP n 
1 217 ARG n 
1 218 TRP n 
1 219 PHE n 
1 220 LEU n 
1 221 ASN n 
1 222 ARG n 
1 223 PHE n 
1 224 THR n 
1 225 THR n 
1 226 THR n 
1 227 LEU n 
1 228 ASN n 
1 229 ASP n 
1 230 PHE n 
1 231 ASN n 
1 232 LEU n 
1 233 VAL n 
1 234 ALA n 
1 235 MET n 
1 236 LYS n 
1 237 TYR n 
1 238 ASN n 
1 239 TYR n 
1 240 GLU n 
1 241 PRO n 
1 242 LEU n 
1 243 THR n 
1 244 GLN n 
1 245 ASP n 
1 246 HIS n 
1 247 VAL n 
1 248 ASP n 
1 249 ILE n 
1 250 LEU n 
1 251 GLY n 
1 252 PRO n 
1 253 LEU n 
1 254 SER n 
1 255 ALA n 
1 256 GLN n 
1 257 THR n 
1 258 GLY n 
1 259 ILE n 
1 260 ALA n 
1 261 VAL n 
1 262 LEU n 
1 263 ASP n 
1 264 MET n 
1 265 CYS n 
1 266 ALA n 
1 267 SER n 
1 268 LEU n 
1 269 LYS n 
1 270 GLU n 
1 271 LEU n 
1 272 LEU n 
1 273 GLN n 
1 274 ASN n 
1 275 GLY n 
1 276 MET n 
1 277 ASN n 
1 278 GLY n 
1 279 ARG n 
1 280 THR n 
1 281 ILE n 
1 282 LEU n 
1 283 GLY n 
1 284 SER n 
1 285 ALA n 
1 286 LEU n 
1 287 LEU n 
1 288 GLU n 
1 289 ASP n 
1 290 GLU n 
1 291 PHE n 
1 292 THR n 
1 293 PRO n 
1 294 PHE n 
1 295 ASP n 
1 296 VAL n 
1 297 VAL n 
1 298 ARG n 
1 299 GLN n 
1 300 CYS n 
1 301 SER n 
1 302 GLY n 
1 303 VAL n 
1 304 THR n 
1 305 PHE n 
1 306 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   306 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'rep, 1a-1b' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                                                                                ? 
'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                                                                               ? 
'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                                                                             ? 
'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                                                                        ? 
'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE                                                                                               ? 
'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE                                                                                              ? 
'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                                                                        ? 
'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                                                                                ? 
'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                                                                                              ? 
'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                                                                                  ? 
'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                                                                             ? 
'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                                                                                ? 
'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                                                                                 ? 
'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                                                                                             ? 
'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE                                                                                          ? 
'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                                                                                                ? 
'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                                                                                 ? 
'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                                                                                              ? 
'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                                                                             ? 
'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                                                                               ? 
'C9 H11 N O3'    181.189 
UED non-polymer         . 'N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide' 
'GC373 bound form, GC376 bound form' 'C21 H31 N3 O5'  405.488 
VAL 'L-peptide linking' y VALINE                                                                                                 ? 
'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   1   1   SER SER A . n 
A 1 2   GLY 2   2   2   GLY GLY A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   ARG 4   4   4   ARG ARG A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   MET 6   6   6   MET MET A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   PRO 9   9   9   PRO PRO A . n 
A 1 10  SER 10  10  10  SER SER A . n 
A 1 11  GLY 11  11  11  GLY GLY A . n 
A 1 12  LYS 12  12  12  LYS LYS A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  GLY 15  15  15  GLY GLY A . n 
A 1 16  CYS 16  16  16  CYS CYS A . n 
A 1 17  MET 17  17  17  MET MET A . n 
A 1 18  VAL 18  18  18  VAL VAL A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  THR 21  21  21  THR THR A . n 
A 1 22  CYS 22  22  22  CYS CYS A . n 
A 1 23  GLY 23  23  23  GLY GLY A . n 
A 1 24  THR 24  24  24  THR THR A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  THR 26  26  26  THR THR A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  ASN 28  28  28  ASN ASN A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  TRP 31  31  31  TRP TRP A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  ASP 33  33  33  ASP ASP A . n 
A 1 34  ASP 34  34  34  ASP ASP A . n 
A 1 35  VAL 35  35  35  VAL VAL A . n 
A 1 36  VAL 36  36  36  VAL VAL A . n 
A 1 37  TYR 37  37  37  TYR TYR A . n 
A 1 38  CYS 38  38  38  CYS CYS A . n 
A 1 39  PRO 39  39  39  PRO PRO A . n 
A 1 40  ARG 40  40  40  ARG ARG A . n 
A 1 41  HIS 41  41  41  HIS HIS A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  ILE 43  43  43  ILE ILE A . n 
A 1 44  CYS 44  44  44  CYS CYS A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  SER 46  46  46  SER SER A . n 
A 1 47  GLU 47  47  47  GLU GLU A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  MET 49  49  49  MET MET A . n 
A 1 50  PHE 50  50  50  PHE PHE A . n 
A 1 51  ASN 51  51  51  ASN ASN A . n 
A 1 52  PRO 52  52  52  PRO PRO A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  TYR 54  54  54  TYR TYR A . n 
A 1 55  GLU 55  55  55  GLU GLU A . n 
A 1 56  ASP 56  56  56  ASP ASP A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  ILE 59  59  59  ILE ILE A . n 
A 1 60  ARG 60  60  60  ARG ARG A . n 
A 1 61  LYS 61  61  61  LYS LYS A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  ASN 63  63  63  ASN ASN A . n 
A 1 64  HIS 64  64  64  HIS HIS A . n 
A 1 65  ASN 65  65  65  ASN ASN A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  GLN 69  69  69  GLN GLN A . n 
A 1 70  ALA 70  70  70  ALA ALA A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  ASN 72  72  72  ASN ASN A . n 
A 1 73  VAL 73  73  73  VAL VAL A . n 
A 1 74  GLN 74  74  74  GLN GLN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  ARG 76  76  76  ARG ARG A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  GLY 79  79  79  GLY GLY A . n 
A 1 80  HIS 80  80  80  HIS HIS A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  MET 82  82  82  MET MET A . n 
A 1 83  GLN 83  83  83  GLN GLN A . n 
A 1 84  ASN 84  84  84  ASN ASN A . n 
A 1 85  CYS 85  85  85  CYS CYS A . n 
A 1 86  VAL 86  86  86  VAL VAL A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  LYS 88  88  88  LYS LYS A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  LYS 90  90  90  LYS LYS A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  ASP 92  92  92  ASP ASP A . n 
A 1 93  THR 93  93  93  THR THR A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  PRO 96  96  96  PRO PRO A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  PRO 99  99  99  PRO PRO A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 TYR 101 101 101 TYR TYR A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 PHE 103 103 103 PHE PHE A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 ARG 105 105 105 ARG ARG A . n 
A 1 106 ILE 106 106 106 ILE ILE A . n 
A 1 107 GLN 107 107 107 GLN GLN A . n 
A 1 108 PRO 108 108 108 PRO PRO A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 GLN 110 110 110 GLN GLN A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 PHE 112 112 112 PHE PHE A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 CYS 117 117 117 CYS CYS A . n 
A 1 118 TYR 118 118 118 TYR TYR A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 SER 123 123 123 SER SER A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 MET 130 130 130 MET MET A . n 
A 1 131 ARG 131 131 131 ARG ARG A . n 
A 1 132 PRO 132 132 132 PRO PRO A . n 
A 1 133 ASN 133 133 133 ASN ASN A . n 
A 1 134 PHE 134 134 134 PHE PHE A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 LYS 137 137 137 LYS LYS A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 PHE 140 140 140 PHE PHE A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 ASN 142 142 142 ASN ASN A . n 
A 1 143 GLY 143 143 143 GLY GLY A . n 
A 1 144 SER 144 144 144 SER SER A . n 
A 1 145 CYS 145 145 145 CYS CYS A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 GLY 149 149 149 GLY GLY A . n 
A 1 150 PHE 150 150 150 PHE PHE A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 ILE 152 152 152 ILE ILE A . n 
A 1 153 ASP 153 153 153 ASP ASP A . n 
A 1 154 TYR 154 154 154 TYR TYR A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 CYS 156 156 156 CYS CYS A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 SER 158 158 158 SER SER A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 CYS 160 160 160 CYS CYS A . n 
A 1 161 TYR 161 161 161 TYR TYR A . n 
A 1 162 MET 162 162 162 MET MET A . n 
A 1 163 HIS 163 163 163 HIS HIS A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 MET 165 165 165 MET MET A . n 
A 1 166 GLU 166 166 166 GLU GLU A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 PRO 168 168 168 PRO PRO A . n 
A 1 169 THR 169 169 169 THR THR A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 VAL 171 171 171 VAL VAL A . n 
A 1 172 HIS 172 172 172 HIS HIS A . n 
A 1 173 VAL 173 173 173 VAL VAL A . n 
A 1 174 GLY 174 174 174 GLY GLY A . n 
A 1 175 THR 175 175 175 THR THR A . n 
A 1 176 ASP 176 176 176 ASP ASP A . n 
A 1 177 LEU 177 177 177 LEU LEU A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 TYR 182 182 182 TYR TYR A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 VAL 186 186 186 VAL VAL A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 GLN 189 189 189 GLN GLN A . n 
A 1 190 THR 190 190 190 THR THR A . n 
A 1 191 ALA 191 191 191 ALA ALA A . n 
A 1 192 GLN 192 192 192 GLN GLN A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 THR 196 196 196 THR THR A . n 
A 1 197 ASP 197 197 197 ASP ASP A . n 
A 1 198 THR 198 198 198 THR THR A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 ILE 200 200 200 ILE ILE A . n 
A 1 201 THR 201 201 201 THR THR A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 ALA 206 206 206 ALA ALA A . n 
A 1 207 TRP 207 207 207 TRP TRP A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ALA 210 210 210 ALA ALA A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ASN 214 214 214 ASN ASN A . n 
A 1 215 GLY 215 215 215 GLY GLY A . n 
A 1 216 ASP 216 216 216 ASP ASP A . n 
A 1 217 ARG 217 217 217 ARG ARG A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 ASN 221 221 221 ASN ASN A . n 
A 1 222 ARG 222 222 222 ARG ARG A . n 
A 1 223 PHE 223 223 223 PHE PHE A . n 
A 1 224 THR 224 224 224 THR THR A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 THR 226 226 226 THR THR A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 ASN 228 228 228 ASN ASN A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 PHE 230 230 230 PHE PHE A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 VAL 233 233 233 VAL VAL A . n 
A 1 234 ALA 234 234 234 ALA ALA A . n 
A 1 235 MET 235 235 235 MET MET A . n 
A 1 236 LYS 236 236 236 LYS LYS A . n 
A 1 237 TYR 237 237 237 TYR TYR A . n 
A 1 238 ASN 238 238 238 ASN ASN A . n 
A 1 239 TYR 239 239 239 TYR TYR A . n 
A 1 240 GLU 240 240 240 GLU GLU A . n 
A 1 241 PRO 241 241 241 PRO PRO A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 THR 243 243 243 THR THR A . n 
A 1 244 GLN 244 244 244 GLN GLN A . n 
A 1 245 ASP 245 245 245 ASP ASP A . n 
A 1 246 HIS 246 246 246 HIS HIS A . n 
A 1 247 VAL 247 247 247 VAL VAL A . n 
A 1 248 ASP 248 248 248 ASP ASP A . n 
A 1 249 ILE 249 249 249 ILE ILE A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 PRO 252 252 252 PRO PRO A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 SER 254 254 254 SER SER A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 THR 257 257 257 THR THR A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 ILE 259 259 259 ILE ILE A . n 
A 1 260 ALA 260 260 260 ALA ALA A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 LEU 262 262 262 LEU LEU A . n 
A 1 263 ASP 263 263 263 ASP ASP A . n 
A 1 264 MET 264 264 264 MET MET A . n 
A 1 265 CYS 265 265 265 CYS CYS A . n 
A 1 266 ALA 266 266 266 ALA ALA A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 LYS 269 269 269 LYS LYS A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 LEU 271 271 271 LEU LEU A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 ASN 274 274 274 ASN ASN A . n 
A 1 275 GLY 275 275 275 GLY GLY A . n 
A 1 276 MET 276 276 276 MET MET A . n 
A 1 277 ASN 277 277 277 ASN ASN A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 ARG 279 279 279 ARG ARG A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 ILE 281 281 281 ILE ILE A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 GLY 283 283 283 GLY GLY A . n 
A 1 284 SER 284 284 284 SER SER A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 LEU 286 286 286 LEU LEU A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 ASP 289 289 289 ASP ASP A . n 
A 1 290 GLU 290 290 290 GLU GLU A . n 
A 1 291 PHE 291 291 291 PHE PHE A . n 
A 1 292 THR 292 292 292 THR THR A . n 
A 1 293 PRO 293 293 293 PRO PRO A . n 
A 1 294 PHE 294 294 294 PHE PHE A . n 
A 1 295 ASP 295 295 295 ASP ASP A . n 
A 1 296 VAL 296 296 296 VAL VAL A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 GLN 299 299 299 GLN GLN A . n 
A 1 300 CYS 300 300 300 CYS CYS A . n 
A 1 301 SER 301 301 301 SER SER A . n 
A 1 302 GLY 302 302 302 GLY GLY A . n 
A 1 303 VAL 303 303 303 VAL VAL A . n 
A 1 304 THR 304 304 ?   ?   ?   A . n 
A 1 305 PHE 305 305 ?   ?   ?   A . n 
A 1 306 GLN 306 306 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        UED 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   UED 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 UED 1   401 999 UED GCA A . 
C 3 HOH 1   501 101 HOH HOH A . 
C 3 HOH 2   502 169 HOH HOH A . 
C 3 HOH 3   503 148 HOH HOH A . 
C 3 HOH 4   504 49  HOH HOH A . 
C 3 HOH 5   505 92  HOH HOH A . 
C 3 HOH 6   506 40  HOH HOH A . 
C 3 HOH 7   507 7   HOH HOH A . 
C 3 HOH 8   508 16  HOH HOH A . 
C 3 HOH 9   509 55  HOH HOH A . 
C 3 HOH 10  510 54  HOH HOH A . 
C 3 HOH 11  511 81  HOH HOH A . 
C 3 HOH 12  512 50  HOH HOH A . 
C 3 HOH 13  513 109 HOH HOH A . 
C 3 HOH 14  514 30  HOH HOH A . 
C 3 HOH 15  515 31  HOH HOH A . 
C 3 HOH 16  516 32  HOH HOH A . 
C 3 HOH 17  517 20  HOH HOH A . 
C 3 HOH 18  518 139 HOH HOH A . 
C 3 HOH 19  519 27  HOH HOH A . 
C 3 HOH 20  520 67  HOH HOH A . 
C 3 HOH 21  521 24  HOH HOH A . 
C 3 HOH 22  522 84  HOH HOH A . 
C 3 HOH 23  523 138 HOH HOH A . 
C 3 HOH 24  524 6   HOH HOH A . 
C 3 HOH 25  525 63  HOH HOH A . 
C 3 HOH 26  526 8   HOH HOH A . 
C 3 HOH 27  527 29  HOH HOH A . 
C 3 HOH 28  528 48  HOH HOH A . 
C 3 HOH 29  529 70  HOH HOH A . 
C 3 HOH 30  530 85  HOH HOH A . 
C 3 HOH 31  531 44  HOH HOH A . 
C 3 HOH 32  532 87  HOH HOH A . 
C 3 HOH 33  533 94  HOH HOH A . 
C 3 HOH 34  534 38  HOH HOH A . 
C 3 HOH 35  535 80  HOH HOH A . 
C 3 HOH 36  536 5   HOH HOH A . 
C 3 HOH 37  537 66  HOH HOH A . 
C 3 HOH 38  538 104 HOH HOH A . 
C 3 HOH 39  539 90  HOH HOH A . 
C 3 HOH 40  540 61  HOH HOH A . 
C 3 HOH 41  541 96  HOH HOH A . 
C 3 HOH 42  542 76  HOH HOH A . 
C 3 HOH 43  543 57  HOH HOH A . 
C 3 HOH 44  544 144 HOH HOH A . 
C 3 HOH 45  545 72  HOH HOH A . 
C 3 HOH 46  546 69  HOH HOH A . 
C 3 HOH 47  547 161 HOH HOH A . 
C 3 HOH 48  548 124 HOH HOH A . 
C 3 HOH 49  549 1   HOH HOH A . 
C 3 HOH 50  550 106 HOH HOH A . 
C 3 HOH 51  551 12  HOH HOH A . 
C 3 HOH 52  552 155 HOH HOH A . 
C 3 HOH 53  553 46  HOH HOH A . 
C 3 HOH 54  554 21  HOH HOH A . 
C 3 HOH 55  555 2   HOH HOH A . 
C 3 HOH 56  556 142 HOH HOH A . 
C 3 HOH 57  557 93  HOH HOH A . 
C 3 HOH 58  558 65  HOH HOH A . 
C 3 HOH 59  559 131 HOH HOH A . 
C 3 HOH 60  560 64  HOH HOH A . 
C 3 HOH 61  561 112 HOH HOH A . 
C 3 HOH 62  562 9   HOH HOH A . 
C 3 HOH 63  563 130 HOH HOH A . 
C 3 HOH 64  564 36  HOH HOH A . 
C 3 HOH 65  565 34  HOH HOH A . 
C 3 HOH 66  566 11  HOH HOH A . 
C 3 HOH 67  567 17  HOH HOH A . 
C 3 HOH 68  568 28  HOH HOH A . 
C 3 HOH 69  569 78  HOH HOH A . 
C 3 HOH 70  570 59  HOH HOH A . 
C 3 HOH 71  571 167 HOH HOH A . 
C 3 HOH 72  572 56  HOH HOH A . 
C 3 HOH 73  573 113 HOH HOH A . 
C 3 HOH 74  574 4   HOH HOH A . 
C 3 HOH 75  575 10  HOH HOH A . 
C 3 HOH 76  576 35  HOH HOH A . 
C 3 HOH 77  577 23  HOH HOH A . 
C 3 HOH 78  578 58  HOH HOH A . 
C 3 HOH 79  579 120 HOH HOH A . 
C 3 HOH 80  580 117 HOH HOH A . 
C 3 HOH 81  581 18  HOH HOH A . 
C 3 HOH 82  582 98  HOH HOH A . 
C 3 HOH 83  583 41  HOH HOH A . 
C 3 HOH 84  584 151 HOH HOH A . 
C 3 HOH 85  585 43  HOH HOH A . 
C 3 HOH 86  586 119 HOH HOH A . 
C 3 HOH 87  587 99  HOH HOH A . 
C 3 HOH 88  588 128 HOH HOH A . 
C 3 HOH 89  589 37  HOH HOH A . 
C 3 HOH 90  590 52  HOH HOH A . 
C 3 HOH 91  591 33  HOH HOH A . 
C 3 HOH 92  592 45  HOH HOH A . 
C 3 HOH 93  593 134 HOH HOH A . 
C 3 HOH 94  594 97  HOH HOH A . 
C 3 HOH 95  595 13  HOH HOH A . 
C 3 HOH 96  596 108 HOH HOH A . 
C 3 HOH 97  597 168 HOH HOH A . 
C 3 HOH 98  598 62  HOH HOH A . 
C 3 HOH 99  599 60  HOH HOH A . 
C 3 HOH 100 600 42  HOH HOH A . 
C 3 HOH 101 601 47  HOH HOH A . 
C 3 HOH 102 602 51  HOH HOH A . 
C 3 HOH 103 603 26  HOH HOH A . 
C 3 HOH 104 604 103 HOH HOH A . 
C 3 HOH 105 605 74  HOH HOH A . 
C 3 HOH 106 606 22  HOH HOH A . 
C 3 HOH 107 607 135 HOH HOH A . 
C 3 HOH 108 608 118 HOH HOH A . 
C 3 HOH 109 609 111 HOH HOH A . 
C 3 HOH 110 610 116 HOH HOH A . 
C 3 HOH 111 611 15  HOH HOH A . 
C 3 HOH 112 612 158 HOH HOH A . 
C 3 HOH 113 613 105 HOH HOH A . 
C 3 HOH 114 614 149 HOH HOH A . 
C 3 HOH 115 615 91  HOH HOH A . 
C 3 HOH 116 616 19  HOH HOH A . 
C 3 HOH 117 617 25  HOH HOH A . 
C 3 HOH 118 618 73  HOH HOH A . 
C 3 HOH 119 619 100 HOH HOH A . 
C 3 HOH 120 620 147 HOH HOH A . 
C 3 HOH 121 621 166 HOH HOH A . 
C 3 HOH 122 622 146 HOH HOH A . 
C 3 HOH 123 623 157 HOH HOH A . 
C 3 HOH 124 624 160 HOH HOH A . 
C 3 HOH 125 625 14  HOH HOH A . 
C 3 HOH 126 626 121 HOH HOH A . 
C 3 HOH 127 627 53  HOH HOH A . 
C 3 HOH 128 628 126 HOH HOH A . 
C 3 HOH 129 629 133 HOH HOH A . 
C 3 HOH 130 630 150 HOH HOH A . 
C 3 HOH 131 631 89  HOH HOH A . 
C 3 HOH 132 632 127 HOH HOH A . 
C 3 HOH 133 633 140 HOH HOH A . 
C 3 HOH 134 634 110 HOH HOH A . 
C 3 HOH 135 635 77  HOH HOH A . 
C 3 HOH 136 636 165 HOH HOH A . 
C 3 HOH 137 637 115 HOH HOH A . 
C 3 HOH 138 638 39  HOH HOH A . 
C 3 HOH 139 639 82  HOH HOH A . 
C 3 HOH 140 640 164 HOH HOH A . 
C 3 HOH 141 641 137 HOH HOH A . 
C 3 HOH 142 642 95  HOH HOH A . 
C 3 HOH 143 643 86  HOH HOH A . 
C 3 HOH 144 644 152 HOH HOH A . 
C 3 HOH 145 645 136 HOH HOH A . 
C 3 HOH 146 646 122 HOH HOH A . 
C 3 HOH 147 647 123 HOH HOH A . 
C 3 HOH 148 648 68  HOH HOH A . 
C 3 HOH 149 649 129 HOH HOH A . 
C 3 HOH 150 650 156 HOH HOH A . 
C 3 HOH 151 651 125 HOH HOH A . 
C 3 HOH 152 652 163 HOH HOH A . 
C 3 HOH 153 653 75  HOH HOH A . 
C 3 HOH 154 654 88  HOH HOH A . 
C 3 HOH 155 655 159 HOH HOH A . 
C 3 HOH 156 656 114 HOH HOH A . 
C 3 HOH 157 657 107 HOH HOH A . 
C 3 HOH 158 658 83  HOH HOH A . 
C 3 HOH 159 659 71  HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A ASN 72  ? CG  ? A ASN 72  CG  
2  1 Y 1 A ASN 72  ? OD1 ? A ASN 72  OD1 
3  1 Y 1 A ASN 72  ? ND2 ? A ASN 72  ND2 
4  1 Y 1 A ARG 188 ? CG  ? A ARG 188 CG  
5  1 Y 1 A ARG 188 ? CD  ? A ARG 188 CD  
6  1 Y 1 A ARG 188 ? NE  ? A ARG 188 NE  
7  1 Y 1 A ARG 188 ? CZ  ? A ARG 188 CZ  
8  1 Y 1 A ARG 188 ? NH1 ? A ARG 188 NH1 
9  1 Y 1 A ARG 188 ? NH2 ? A ARG 188 NH2 
10 1 Y 1 A ASN 228 ? CG  ? A ASN 228 CG  
11 1 Y 1 A ASN 228 ? OD1 ? A ASN 228 OD1 
12 1 Y 1 A ASN 228 ? ND2 ? A ASN 228 ND2 
13 1 Y 1 A GLN 256 ? CG  ? A GLN 256 CG  
14 1 Y 1 A GLN 256 ? CD  ? A GLN 256 CD  
15 1 Y 1 A GLN 256 ? OE1 ? A GLN 256 OE1 
16 1 Y 1 A GLN 256 ? NE2 ? A GLN 256 NE2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   102.363 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BOB 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     114.629 
_cell.length_a_esd                 ? 
_cell.length_b                     53.273 
_cell.length_b_esd                 ? 
_cell.length_c                     45.496 
_cell.length_c_esd                 ? 
_cell.volume                       271384.664 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BOB 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y' 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BOB 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.00 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          38.56 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              3.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '4% v/v (+/-)-2-Methyl-2,4-pentanediol, 0.1 M Citric acid, 20% w/v Polyethylene glycol 1,500' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            294 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-11-30 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.920085 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSLS-II BEAMLINE 17-ID-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.920085 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   17-ID-1 
_diffrn_source.pdbx_synchrotron_site       NSLS-II 
# 
_reflns.B_iso_Wilson_estimate                          27.45 
_reflns.entry_id                                       9BOB 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.87 
_reflns.d_resolution_low                               31.66 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     22234 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.14 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.3 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          7.78 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.996 
_reflns.pdbx_CC_star                                   0.999 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.1394 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.87 
_reflns_shell.d_res_low                                     1.937 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.13 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2177 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               6.6 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.439 
_reflns_shell.pdbx_CC_star                                  0.781 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          98.28 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.706 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               32.86 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9BOB 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.87 
_refine.ls_d_res_low                             31.66 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     22234 
_refine.ls_number_reflns_R_free                  1109 
_refine.ls_number_reflns_R_work                  21125 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.16 
_refine.ls_percent_reflns_R_free                 4.99 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2019 
_refine.ls_R_factor_R_free                       0.2386 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2000 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 25.6437 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2080 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.87 
_refine_hist.d_res_low                        31.66 
_refine_hist.number_atoms_solvent             159 
_refine_hist.number_atoms_total               2517 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2329 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         29 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0027  ? 2419 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.6306  ? 3289 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0417  ? 371  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0041  ? 426  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 12.9604 ? 855  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.87 1.95  . . 140 2615 98.36 . . . . 0.2864 . . . . . . . . . . . 0.3406 
'X-RAY DIFFRACTION' 1.95 2.06  . . 131 2620 98.74 . . . . 0.2495 . . . . . . . . . . . 0.2837 
'X-RAY DIFFRACTION' 2.06 2.18  . . 144 2613 98.96 . . . . 0.2384 . . . . . . . . . . . 0.2824 
'X-RAY DIFFRACTION' 2.18 2.35  . . 120 2629 99.17 . . . . 0.2328 . . . . . . . . . . . 0.2723 
'X-RAY DIFFRACTION' 2.35 2.59  . . 140 2625 99.35 . . . . 0.2279 . . . . . . . . . . . 0.3113 
'X-RAY DIFFRACTION' 2.59 2.96  . . 138 2640 99.36 . . . . 0.2145 . . . . . . . . . . . 0.2423 
'X-RAY DIFFRACTION' 2.96 3.73  . . 142 2667 99.61 . . . . 0.1837 . . . . . . . . . . . 0.2427 
'X-RAY DIFFRACTION' 3.73 31.66 . . 154 2716 99.83 . . . . 0.1644 . . . . . . . . . . . 0.1861 
# 
_struct.entry_id                     9BOB 
_struct.title                        'Crystal Structure of A173V/L50F SARS-CoV-2 Main Protease in Complex with GC376' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BOB 
_struct_keywords.text            'Hydrolase, VIRAL PROTEIN' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1AB_SARS2 
_struct_ref.pdbx_db_accession          P0DTD1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_struct_ref.pdbx_align_begin           3264 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9BOB 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 306 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P0DTD1 
_struct_ref_seq.db_align_beg                  3264 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3569 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       306 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9BOB PHE A 50  ? UNP P0DTD1 LEU 3313 'engineered mutation' 50  1 
1 9BOB VAL A 173 ? UNP P0DTD1 ALA 3436 'engineered mutation' 173 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2760  ? 
1 MORE         -16   ? 
1 'SSA (A^2)'  25110 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z     1.0000000000  0.0000000000 0.0000000000 0.0000000000  0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000  
2 'crystal symmetry operation' 2_556 -x,y,-z+1 -1.0000000000 0.0000000000 0.0000000000 -9.7409017441 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 44.4409816409 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 10  ? GLY A 15  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 41  ? CYS A 44  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 GLU A 47  ? ASN A 51  ? GLU A 47  ASN A 51  5 ? 5  
HELX_P HELX_P4  AA4 ASN A 53  ? ILE A 59  ? ASN A 53  ILE A 59  1 ? 7  
HELX_P HELX_P5  AA5 ARG A 60  ? LYS A 61  ? ARG A 60  LYS A 61  5 ? 2  
HELX_P HELX_P6  AA6 SER A 62  ? HIS A 64  ? SER A 62  HIS A 64  5 ? 3  
HELX_P HELX_P7  AA7 ILE A 200 ? ASN A 214 ? ILE A 200 ASN A 214 1 ? 15 
HELX_P HELX_P8  AA8 THR A 226 ? TYR A 237 ? THR A 226 TYR A 237 1 ? 12 
HELX_P HELX_P9  AA9 THR A 243 ? LEU A 250 ? THR A 243 LEU A 250 1 ? 8  
HELX_P HELX_P10 AB1 LEU A 250 ? THR A 257 ? LEU A 250 THR A 257 1 ? 8  
HELX_P HELX_P11 AB2 ALA A 260 ? GLY A 275 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P12 AB3 THR A 292 ? CYS A 300 ? THR A 292 CYS A 300 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            covale1 
_struct_conn.conn_type_id                  covale 
_struct_conn.pdbx_leaving_atom_flag        one 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            145 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           B 
_struct_conn.ptnr2_label_comp_id           UED 
_struct_conn.ptnr2_label_seq_id            . 
_struct_conn.ptnr2_label_atom_id           C21 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             145 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            UED 
_struct_conn.ptnr2_auth_seq_id             401 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               1.765 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      UED 
_pdbx_modification_feature.label_asym_id                      B 
_pdbx_modification_feature.label_seq_id                       . 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      145 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       UED 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        401 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       145 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               C21 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                CYS 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        UED 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Covalent chemical modification' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 73  ? LEU A 75  ? VAL A 73  LEU A 75  
AA1 2 PHE A 66  ? ALA A 70  ? PHE A 66  ALA A 70  
AA1 3 MET A 17  ? CYS A 22  ? MET A 17  CYS A 22  
AA1 4 THR A 25  ? LEU A 32  ? THR A 25  LEU A 32  
AA1 5 VAL A 35  ? PRO A 39  ? VAL A 35  PRO A 39  
AA1 6 VAL A 86  ? VAL A 91  ? VAL A 86  VAL A 91  
AA1 7 VAL A 77  ? GLN A 83  ? VAL A 77  GLN A 83  
AA2 1 LYS A 100 ? PHE A 103 ? LYS A 100 PHE A 103 
AA2 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA2 3 VAL A 148 ? ASP A 153 ? VAL A 148 ASP A 153 
AA2 4 THR A 111 ? TYR A 118 ? THR A 111 TYR A 118 
AA2 5 SER A 121 ? ALA A 129 ? SER A 121 ALA A 129 
AA3 1 LYS A 100 ? PHE A 103 ? LYS A 100 PHE A 103 
AA3 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA3 3 HIS A 172 ? THR A 175 ? HIS A 172 THR A 175 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL A 73  ? O VAL A 73  N ALA A 70  ? N ALA A 70  
AA1 2 3 O LEU A 67  ? O LEU A 67  N THR A 21  ? N THR A 21  
AA1 3 4 N VAL A 20  ? N VAL A 20  O LEU A 27  ? O LEU A 27  
AA1 4 5 N LEU A 30  ? N LEU A 30  O TYR A 37  ? O TYR A 37  
AA1 5 6 N CYS A 38  ? N CYS A 38  O LEU A 87  ? O LEU A 87  
AA1 6 7 O LYS A 88  ? O LYS A 88  N SER A 81  ? N SER A 81  
AA2 1 2 N LYS A 100 ? N LYS A 100 O VAL A 157 ? O VAL A 157 
AA2 2 3 O SER A 158 ? O SER A 158 N ASN A 151 ? N ASN A 151 
AA2 3 4 O PHE A 150 ? O PHE A 150 N SER A 113 ? N SER A 113 
AA2 4 5 N ALA A 116 ? N ALA A 116 O SER A 123 ? O SER A 123 
AA3 1 2 N LYS A 100 ? N LYS A 100 O VAL A 157 ? O VAL A 157 
AA3 2 3 N MET A 165 ? N MET A 165 O VAL A 173 ? O VAL A 173 
# 
_pdbx_entry_details.entry_id                   9BOB 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 33  ? ? 52.18   -135.12 
2 1 ASN A 51  ? ? -162.46 78.54   
3 1 ASN A 84  ? ? 54.28   -119.70 
4 1 TYR A 154 ? ? 53.15   -96.92  
5 1 HIS A 164 ? ? -132.95 -36.84  
6 1 PRO A 184 ? ? -91.12  47.42   
# 
_pdbx_molecule_features.prd_id    PRD_002495 
_pdbx_molecule_features.name      GC376 
_pdbx_molecule_features.type      Peptide-like 
_pdbx_molecule_features.class     Inhibitor 
_pdbx_molecule_features.details   ? 
# 
_pdbx_molecule.instance_id   1 
_pdbx_molecule.prd_id        PRD_002495 
_pdbx_molecule.asym_id       B 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 616 ? C HOH . 
2 1 A HOH 628 ? C HOH . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 -x,y,-z         
3 x+1/2,y+1/2,z   
4 -x+1/2,y+1/2,-z 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A THR 304 ? A THR 304 
2 1 Y 1 A PHE 305 ? A PHE 305 
3 1 Y 1 A GLN 306 ? A GLN 306 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
UED C7   C N N 372 
UED O8   O N N 373 
UED C9   C N N 374 
UED O10  O N N 375 
UED C1   C Y N 376 
UED C2   C Y N 377 
UED C3   C Y N 378 
UED C4   C Y N 379 
UED C5   C Y N 380 
UED C6   C Y N 381 
UED N11  N N N 382 
UED C12  C N S 383 
UED C17  C N N 384 
UED O18  O N N 385 
UED C13  C N N 386 
UED C14  C N N 387 
UED C15  C N N 388 
UED C16  C N N 389 
UED N19  N N N 390 
UED C20  C N S 391 
UED C21  C N N 392 
UED O22  O N N 393 
UED C24  C N N 394 
UED C25  C N S 395 
UED C26  C N N 396 
UED C27  C N N 397 
UED N28  N N N 398 
UED C29  C N N 399 
UED O30  O N N 400 
UED H1   H N N 401 
UED H2   H N N 402 
UED H3   H N N 403 
UED H4   H N N 404 
UED H5   H N N 405 
UED H6   H N N 406 
UED H7   H N N 407 
UED H8   H N N 408 
UED H9   H N N 409 
UED H10  H N N 410 
UED H11  H N N 411 
UED H12  H N N 412 
UED H13  H N N 413 
UED H14  H N N 414 
UED H15  H N N 415 
UED H16  H N N 416 
UED H17  H N N 417 
UED H18  H N N 418 
UED H19  H N N 419 
UED H20  H N N 420 
UED H21  H N N 421 
UED H22  H N N 422 
UED H23  H N N 423 
UED H24  H N N 424 
UED H25  H N N 425 
UED H26  H N N 426 
UED H27  H N N 427 
UED H28  H N N 428 
UED H29  H N N 429 
UED H30  H N N 430 
UED H31  H N N 431 
VAL N    N N N 432 
VAL CA   C N S 433 
VAL C    C N N 434 
VAL O    O N N 435 
VAL CB   C N N 436 
VAL CG1  C N N 437 
VAL CG2  C N N 438 
VAL OXT  O N N 439 
VAL H    H N N 440 
VAL H2   H N N 441 
VAL HA   H N N 442 
VAL HB   H N N 443 
VAL HG11 H N N 444 
VAL HG12 H N N 445 
VAL HG13 H N N 446 
VAL HG21 H N N 447 
VAL HG22 H N N 448 
VAL HG23 H N N 449 
VAL HXT  H N N 450 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
UED C16 C14  sing N N 358 
UED C3  C2   doub Y N 359 
UED C3  C4   sing Y N 360 
UED C2  C1   sing Y N 361 
UED C14 C13  sing N N 362 
UED C14 C15  sing N N 363 
UED C13 C12  sing N N 364 
UED C4  C5   doub Y N 365 
UED O8  C7   sing N N 366 
UED O8  C9   sing N N 367 
UED N11 C12  sing N N 368 
UED N11 C9   sing N N 369 
UED C1  C7   sing N N 370 
UED C1  C6   doub Y N 371 
UED O18 C17  doub N N 372 
UED C5  C6   sing Y N 373 
UED C12 C17  sing N N 374 
UED C9  O10  doub N N 375 
UED C17 N19  sing N N 376 
UED C26 C27  sing N N 377 
UED C26 C25  sing N N 378 
UED N19 C20  sing N N 379 
UED C20 C21  sing N N 380 
UED C20 C24  sing N N 381 
UED C27 N28  sing N N 382 
UED O22 C21  sing N N 383 
UED C25 C24  sing N N 384 
UED C25 C29  sing N N 385 
UED N28 C29  sing N N 386 
UED C29 O30  doub N N 387 
UED C7  H1   sing N N 388 
UED C7  H2   sing N N 389 
UED C2  H3   sing N N 390 
UED C3  H4   sing N N 391 
UED C4  H5   sing N N 392 
UED C5  H6   sing N N 393 
UED C6  H7   sing N N 394 
UED N11 H8   sing N N 395 
UED C12 H9   sing N N 396 
UED C13 H10  sing N N 397 
UED C13 H11  sing N N 398 
UED C14 H12  sing N N 399 
UED C15 H13  sing N N 400 
UED C15 H14  sing N N 401 
UED C15 H15  sing N N 402 
UED C16 H16  sing N N 403 
UED C16 H17  sing N N 404 
UED C16 H18  sing N N 405 
UED N19 H19  sing N N 406 
UED C20 H20  sing N N 407 
UED C24 H21  sing N N 408 
UED C24 H22  sing N N 409 
UED C25 H23  sing N N 410 
UED C26 H24  sing N N 411 
UED C26 H25  sing N N 412 
UED C27 H26  sing N N 413 
UED C27 H27  sing N N 414 
UED N28 H28  sing N N 415 
UED C21 H29  sing N N 416 
UED C21 H30  sing N N 417 
UED O22 H31  sing N N 418 
VAL N   CA   sing N N 419 
VAL N   H    sing N N 420 
VAL N   H2   sing N N 421 
VAL CA  C    sing N N 422 
VAL CA  CB   sing N N 423 
VAL CA  HA   sing N N 424 
VAL C   O    doub N N 425 
VAL C   OXT  sing N N 426 
VAL CB  CG1  sing N N 427 
VAL CB  CG2  sing N N 428 
VAL CB  HB   sing N N 429 
VAL CG1 HG11 sing N N 430 
VAL CG1 HG12 sing N N 431 
VAL CG1 HG13 sing N N 432 
VAL CG2 HG21 sing N N 433 
VAL CG2 HG22 sing N N 434 
VAL CG2 HG23 sing N N 435 
VAL OXT HXT  sing N N 436 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' 'P30 GM133893' 1 
'Department of Energy (DOE, United States)'                                                'United States' KP1607011      2 
'Other government'                                                                         ?               DE-SC0012704   3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7NF5 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'C 1 2 1' 
_space_group.name_Hall        'C 2y' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9BOB 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.008724 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.001912 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.018771 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.022502 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . SER A 1 1   ? -1.67981  -22.31025 39.31027  1.000 28.09259 ? 1   SER A N    1 
ATOM   2    C CA   . SER A 1 1   ? -2.56389  -21.32051 38.63852  1.000 30.20537 ? 1   SER A CA   1 
ATOM   3    C C    . SER A 1 1   ? -2.18782  -21.18779 37.16622  1.000 34.35818 ? 1   SER A C    1 
ATOM   4    O O    . SER A 1 1   ? -1.42080  -21.99417 36.63321  1.000 29.76397 ? 1   SER A O    1 
ATOM   5    C CB   . SER A 1 1   ? -2.48607  -19.96211 39.34523  1.000 32.05775 ? 1   SER A CB   1 
ATOM   6    O OG   . SER A 1 1   ? -1.18035  -19.41029 39.28000  1.000 32.93094 ? 1   SER A OG   1 
ATOM   7    H H1   . SER A 1 1   ? -0.93460  -21.90630 39.58154  1.000 33.73389 ? 1   SER A H1   1 
ATOM   8    H H2   . SER A 1 1   ? -2.10225  -22.65648 40.01296  1.000 33.73389 ? 1   SER A H2   1 
ATOM   9    H H3   . SER A 1 1   ? -1.47364  -22.96015 38.73824  1.000 33.73389 ? 1   SER A H3   1 
ATOM   10   H HA   . SER A 1 1   ? -3.48552  -21.61893 38.68804  1.000 36.26922 ? 1   SER A HA   1 
ATOM   11   H HB2  . SER A 1 1   ? -3.10514  -19.35096 38.91610  1.000 38.49207 ? 1   SER A HB2  1 
ATOM   12   H HB3  . SER A 1 1   ? -2.72886  -20.08046 40.27686  1.000 38.49207 ? 1   SER A HB3  1 
ATOM   13   H HG   . SER A 1 1   ? -0.98666  -19.22386 38.48417  1.000 39.53991 ? 1   SER A HG   1 
ATOM   14   N N    . GLY A 1 2   ? -2.73009  -20.17092 36.52013  1.000 31.61949 ? 2   GLY A N    1 
ATOM   15   C CA   . GLY A 1 2   ? -2.59165  -20.00225 35.08992  1.000 28.50380 ? 2   GLY A CA   1 
ATOM   16   C C    . GLY A 1 2   ? -3.86186  -20.40283 34.36290  1.000 26.89408 ? 2   GLY A C    1 
ATOM   17   O O    . GLY A 1 2   ? -4.66359  -21.21300 34.84535  1.000 33.02128 ? 2   GLY A O    1 
ATOM   18   H H    . GLY A 1 2   ? -3.19310  -19.55202 36.89721  1.000 37.96616 ? 2   GLY A H    1 
ATOM   19   H HA2  . GLY A 1 2   ? -2.39890  -19.07308 34.88891  1.000 34.22734 ? 2   GLY A HA2  1 
ATOM   20   H HA3  . GLY A 1 2   ? -1.86192  -20.55331 34.76632  1.000 34.22734 ? 2   GLY A HA3  1 
ATOM   21   N N    . PHE A 1 3   ? -4.05740  -19.82290 33.18247  1.000 27.58006 ? 3   PHE A N    1 
ATOM   22   C CA   . PHE A 1 3   ? -5.25838  -20.06632 32.39547  1.000 31.23272 ? 3   PHE A CA   1 
ATOM   23   C C    . PHE A 1 3   ? -4.88906  -20.09349 30.92238  1.000 29.78510 ? 3   PHE A C    1 
ATOM   24   O O    . PHE A 1 3   ? -4.26435  -19.15514 30.41983  1.000 32.95008 ? 3   PHE A O    1 
ATOM   25   C CB   . PHE A 1 3   ? -6.31575  -18.99016 32.65890  1.000 31.67395 ? 3   PHE A CB   1 
ATOM   26   C CG   . PHE A 1 3   ? -7.69823  -19.38271 32.23188  1.000 33.65888 ? 3   PHE A CG   1 
ATOM   27   C CD1  . PHE A 1 3   ? -8.42536  -20.30121 32.96964  1.000 33.18446 ? 3   PHE A CD1  1 
ATOM   28   C CD2  . PHE A 1 3   ? -8.27583  -18.82827 31.10185  1.000 32.95740 ? 3   PHE A CD2  1 
ATOM   29   C CE1  . PHE A 1 3   ? -9.69887  -20.66467 32.58626  1.000 39.38373 ? 3   PHE A CE1  1 
ATOM   30   C CE2  . PHE A 1 3   ? -9.55167  -19.18737 30.71454  1.000 34.52750 ? 3   PHE A CE2  1 
ATOM   31   C CZ   . PHE A 1 3   ? -10.26283 -20.10577 31.45614  1.000 37.34113 ? 3   PHE A CZ   1 
ATOM   32   H H    . PHE A 1 3   ? -3.50245  -19.27918 32.81368  1.000 33.11885 ? 3   PHE A H    1 
ATOM   33   H HA   . PHE A 1 3   ? -5.63432  -20.92916 32.63018  1.000 37.50204 ? 3   PHE A HA   1 
ATOM   34   H HB2  . PHE A 1 3   ? -6.34153  -18.80491 33.61070  1.000 38.03152 ? 3   PHE A HB2  1 
ATOM   35   H HB3  . PHE A 1 3   ? -6.07212  -18.18783 32.17124  1.000 38.03152 ? 3   PHE A HB3  1 
ATOM   36   H HD1  . PHE A 1 3   ? -8.05032  -20.67754 33.73294  1.000 39.84413 ? 3   PHE A HD1  1 
ATOM   37   H HD2  . PHE A 1 3   ? -7.79958  -18.20779 30.59876  1.000 39.57166 ? 3   PHE A HD2  1 
ATOM   38   H HE1  . PHE A 1 3   ? -10.17720 -21.28494 33.08762  1.000 47.28326 ? 3   PHE A HE1  1 
ATOM   39   H HE2  . PHE A 1 3   ? -9.93071  -18.80977 29.95385  1.000 41.45578 ? 3   PHE A HE2  1 
ATOM   40   H HZ   . PHE A 1 3   ? -11.12187 -20.34903 31.19582  1.000 44.83213 ? 3   PHE A HZ   1 
ATOM   41   N N    . ARG A 1 4   ? -5.28863  -21.16304 30.23738  1.000 32.63616 ? 4   ARG A N    1 
ATOM   42   C CA   . ARG A 1 4   ? -4.92167  -21.39641 28.84879  1.000 28.33346 ? 4   ARG A CA   1 
ATOM   43   C C    . ARG A 1 4   ? -6.11912  -21.96297 28.09796  1.000 31.43078 ? 4   ARG A C    1 
ATOM   44   O O    . ARG A 1 4   ? -7.02382  -22.55599 28.69146  1.000 32.35086 ? 4   ARG A O    1 
ATOM   45   C CB   . ARG A 1 4   ? -3.73550  -22.36737 28.74550  1.000 32.45435 ? 4   ARG A CB   1 
ATOM   46   C CG   . ARG A 1 4   ? -2.42016  -21.81839 29.28303  1.000 32.43831 ? 4   ARG A CG   1 
ATOM   47   C CD   . ARG A 1 4   ? -1.91183  -20.67199 28.42827  1.000 33.30709 ? 4   ARG A CD   1 
ATOM   48   N NE   . ARG A 1 4   ? -2.01409  -20.99141 27.01077  1.000 34.82022 ? 4   ARG A NE   1 
ATOM   49   C CZ   . ARG A 1 4   ? -1.17635  -21.78724 26.36212  1.000 35.66411 ? 4   ARG A CZ   1 
ATOM   50   N NH1  . ARG A 1 4   ? -0.13852  -22.34044 26.96943  1.000 35.30334 ? 4   ARG A NH1  1 
ATOM   51   N NH2  . ARG A 1 4   ? -1.38781  -22.03770 25.07317  1.000 36.77735 ? 4   ARG A NH2  1 
ATOM   52   H H    . ARG A 1 4   ? -5.78611  -21.78265 30.56633  1.000 39.18617 ? 4   ARG A H    1 
ATOM   53   H HA   . ARG A 1 4   ? -4.67557  -20.55469 28.43425  1.000 34.02293 ? 4   ARG A HA   1 
ATOM   54   H HB2  . ARG A 1 4   ? -3.94693  -23.16799 29.25067  1.000 38.96800 ? 4   ARG A HB2  1 
ATOM   55   H HB3  . ARG A 1 4   ? -3.59969  -22.59069 27.81138  1.000 38.96800 ? 4   ARG A HB3  1 
ATOM   56   H HG2  . ARG A 1 4   ? -2.55288  -21.49088 30.18637  1.000 38.94875 ? 4   ARG A HG2  1 
ATOM   57   H HG3  . ARG A 1 4   ? -1.75220  -22.52176 29.27993  1.000 38.94875 ? 4   ARG A HG3  1 
ATOM   58   H HD2  . ARG A 1 4   ? -2.44216  -19.87889 28.60332  1.000 39.99128 ? 4   ARG A HD2  1 
ATOM   59   H HD3  . ARG A 1 4   ? -0.98032  -20.50117 28.63808  1.000 39.99128 ? 4   ARG A HD3  1 
ATOM   60   H HE   . ARG A 1 4   ? -2.66074  -20.64039 26.56554  1.000 41.80704 ? 4   ARG A HE   1 
ATOM   61   H HH11 . ARG A 1 4   ? 0.00405   -22.18626 27.80339  1.000 42.38678 ? 4   ARG A HH11 1 
ATOM   62   H HH12 . ARG A 1 4   ? 0.39322   -22.85405 26.53005  1.000 42.38678 ? 4   ARG A HH12 1 
ATOM   63   H HH21 . ARG A 1 4   ? -2.06132  -21.68475 24.67140  1.000 44.15560 ? 4   ARG A HH21 1 
ATOM   64   H HH22 . ARG A 1 4   ? -0.85105  -22.55260 24.64147  1.000 44.15560 ? 4   ARG A HH22 1 
ATOM   65   N N    . LYS A 1 5   ? -6.11831  -21.77439 26.77754  1.000 28.37827 ? 5   LYS A N    1 
ATOM   66   C CA   . LYS A 1 5   ? -7.11809  -22.39916 25.91579  1.000 30.87310 ? 5   LYS A CA   1 
ATOM   67   C C    . LYS A 1 5   ? -6.71979  -23.85830 25.73155  1.000 30.20478 ? 5   LYS A C    1 
ATOM   68   O O    . LYS A 1 5   ? -5.71476  -24.16079 25.08030  1.000 30.22738 ? 5   LYS A O    1 
ATOM   69   C CB   . LYS A 1 5   ? -7.22957  -21.67372 24.57821  1.000 34.13911 ? 5   LYS A CB   1 
ATOM   70   C CG   . LYS A 1 5   ? -8.48550  -22.05022 23.80382  1.000 38.82548 ? 5   LYS A CG   1 
ATOM   71   C CD   . LYS A 1 5   ? -8.78074  -21.06740 22.68635  1.000 42.40100 ? 5   LYS A CD   1 
ATOM   72   C CE   . LYS A 1 5   ? -9.60384  -19.89028 23.18812  1.000 43.79676 ? 5   LYS A CE   1 
ATOM   73   N NZ   . LYS A 1 5   ? -9.57728  -18.74805 22.23669  1.000 44.78411 ? 5   LYS A NZ   1 
ATOM   74   H H    . LYS A 1 5   ? -5.54717  -21.28760 26.35752  1.000 34.07670 ? 5   LYS A H    1 
ATOM   75   H HA   . LYS A 1 5   ? -7.99121  -22.35296 26.33583  1.000 37.07050 ? 5   LYS A HA   1 
ATOM   76   H HB2  . LYS A 1 5   ? -7.25181  -20.71742 24.73914  1.000 40.98971 ? 5   LYS A HB2  1 
ATOM   77   H HB3  . LYS A 1 5   ? -6.46095  -21.90038 24.03164  1.000 40.98971 ? 5   LYS A HB3  1 
ATOM   78   H HG2  . LYS A 1 5   ? -8.36676  -22.92893 23.41054  1.000 46.61336 ? 5   LYS A HG2  1 
ATOM   79   H HG3  . LYS A 1 5   ? -9.24363  -22.05725 24.40887  1.000 46.61336 ? 5   LYS A HG3  1 
ATOM   80   H HD2  . LYS A 1 5   ? -7.94611  -20.72633 22.32864  1.000 50.90398 ? 5   LYS A HD2  1 
ATOM   81   H HD3  . LYS A 1 5   ? -9.28263  -21.51553 21.98765  1.000 50.90398 ? 5   LYS A HD3  1 
ATOM   82   H HE2  . LYS A 1 5   ? -10.52584 -20.16995 23.30039  1.000 52.57889 ? 5   LYS A HE2  1 
ATOM   83   H HE3  . LYS A 1 5   ? -9.24357  -19.58694 24.03611  1.000 52.57889 ? 5   LYS A HE3  1 
ATOM   84   H HZ1  . LYS A 1 5   ? -9.80377  -19.02528 21.42186  1.000 53.76371 ? 5   LYS A HZ1  1 
ATOM   85   H HZ2  . LYS A 1 5   ? -10.15162 -18.12054 22.49833  1.000 53.76371 ? 5   LYS A HZ2  1 
ATOM   86   H HZ3  . LYS A 1 5   ? -8.76012  -18.39679 22.20553  1.000 53.76371 ? 5   LYS A HZ3  1 
ATOM   87   N N    . MET A 1 6   ? -7.50265  -24.76014 26.31241  1.000 29.01335 ? 6   MET A N    1 
ATOM   88   C CA   . MET A 1 6   ? -7.11060  -26.14734 26.50303  1.000 29.35772 ? 6   MET A CA   1 
ATOM   89   C C    . MET A 1 6   ? -8.08535  -27.05425 25.77300  1.000 25.80425 ? 6   MET A C    1 
ATOM   90   O O    . MET A 1 6   ? -9.30298  -26.90857 25.91941  1.000 27.36194 ? 6   MET A O    1 
ATOM   91   C CB   . MET A 1 6   ? -7.08672  -26.47538 27.99493  1.000 30.72347 ? 6   MET A CB   1 
ATOM   92   C CG   . MET A 1 6   ? -6.30207  -27.70624 28.37166  1.000 35.68714 ? 6   MET A CG   1 
ATOM   93   S SD   . MET A 1 6   ? -6.32266  -27.96640 30.16131  1.000 40.90767 ? 6   MET A SD   1 
ATOM   94   C CE   . MET A 1 6   ? -5.58734  -26.44466 30.75779  1.000 30.44093 ? 6   MET A CE   1 
ATOM   95   H H    . MET A 1 6   ? -8.28917  -24.58484 26.61283  1.000 34.83879 ? 6   MET A H    1 
ATOM   96   H HA   . MET A 1 6   ? -6.22530  -26.29639 26.13569  1.000 35.25205 ? 6   MET A HA   1 
ATOM   97   H HB2  . MET A 1 6   ? -6.69249  -25.72510 28.46670  1.000 36.89094 ? 6   MET A HB2  1 
ATOM   98   H HB3  . MET A 1 6   ? -7.99978  -26.61175 28.29266  1.000 36.89094 ? 6   MET A HB3  1 
ATOM   99   H HG2  . MET A 1 6   ? -6.69506  -28.48297 27.94371  1.000 42.84735 ? 6   MET A HG2  1 
ATOM   100  H HG3  . MET A 1 6   ? -5.38074  -27.60125 28.08701  1.000 42.84735 ? 6   MET A HG3  1 
ATOM   101  H HE1  . MET A 1 6   ? -6.18921  -25.70781 30.56882  1.000 36.55190 ? 6   MET A HE1  1 
ATOM   102  H HE2  . MET A 1 6   ? -5.44338  -26.51720 31.71431  1.000 36.55190 ? 6   MET A HE2  1 
ATOM   103  H HE3  . MET A 1 6   ? -4.74072  -26.30455 30.30557  1.000 36.55190 ? 6   MET A HE3  1 
ATOM   104  N N    . ALA A 1 7   ? -7.55283  -27.97954 24.98602  1.000 24.76808 ? 7   ALA A N    1 
ATOM   105  C CA   . ALA A 1 7   ? -8.37459  -28.96968 24.31369  1.000 24.94602 ? 7   ALA A CA   1 
ATOM   106  C C    . ALA A 1 7   ? -8.43105  -30.24775 25.13907  1.000 22.91758 ? 7   ALA A C    1 
ATOM   107  O O    . ALA A 1 7   ? -7.53632  -30.53522 25.93858  1.000 25.25458 ? 7   ALA A O    1 
ATOM   108  C CB   . ALA A 1 7   ? -7.82860  -29.27758 22.91979  1.000 26.60102 ? 7   ALA A CB   1 
ATOM   109  H H    . ALA A 1 7   ? -6.71103  -28.05294 24.82603  1.000 29.74447 ? 7   ALA A H    1 
ATOM   110  H HA   . ALA A 1 7   ? -9.27665  -28.62726 24.21400  1.000 29.95800 ? 7   ALA A HA   1 
ATOM   111  H HB1  . ALA A 1 7   ? -7.83176  -28.46345 22.39246  1.000 31.94400 ? 7   ALA A HB1  1 
ATOM   112  H HB2  . ALA A 1 7   ? -6.92277  -29.61444 23.00276  1.000 31.94400 ? 7   ALA A HB2  1 
ATOM   113  H HB3  . ALA A 1 7   ? -8.39284  -29.94571 22.50010  1.000 31.94400 ? 7   ALA A HB3  1 
ATOM   114  N N    . PHE A 1 8   ? -9.50099  -31.01080 24.94648  1.000 23.65651 ? 8   PHE A N    1 
ATOM   115  C CA   . PHE A 1 8   ? -9.56700  -32.32727 25.55492  1.000 26.86036 ? 8   PHE A CA   1 
ATOM   116  C C    . PHE A 1 8   ? -8.45678  -33.21114 24.99319  1.000 26.57073 ? 8   PHE A C    1 
ATOM   117  O O    . PHE A 1 8   ? -8.03700  -33.03914 23.84448  1.000 27.65533 ? 8   PHE A O    1 
ATOM   118  C CB   . PHE A 1 8   ? -10.91475 -32.98946 25.29109  1.000 24.97291 ? 8   PHE A CB   1 
ATOM   119  C CG   . PHE A 1 8   ? -12.05866 -32.33099 25.99220  1.000 25.23485 ? 8   PHE A CG   1 
ATOM   120  C CD1  . PHE A 1 8   ? -12.41077 -32.70588 27.27793  1.000 31.58772 ? 8   PHE A CD1  1 
ATOM   121  C CD2  . PHE A 1 8   ? -12.78402 -31.33404 25.36655  1.000 28.25847 ? 8   PHE A CD2  1 
ATOM   122  C CE1  . PHE A 1 8   ? -13.46960 -32.09678 27.92390  1.000 35.01433 ? 8   PHE A CE1  1 
ATOM   123  C CE2  . PHE A 1 8   ? -13.83840 -30.72293 26.00606  1.000 30.74501 ? 8   PHE A CE2  1 
ATOM   124  C CZ   . PHE A 1 8   ? -14.18455 -31.10388 27.28535  1.000 30.94832 ? 8   PHE A CZ   1 
ATOM   125  H H    . PHE A 1 8   ? -10.18741 -30.79206 24.47683  1.000 28.41059 ? 8   PHE A H    1 
ATOM   126  H HA   . PHE A 1 8   ? -9.45573  -32.23776 26.51435  1.000 32.25521 ? 8   PHE A HA   1 
ATOM   127  H HB2  . PHE A 1 8   ? -11.09525 -32.95996 24.33849  1.000 29.99027 ? 8   PHE A HB2  1 
ATOM   128  H HB3  . PHE A 1 8   ? -10.87374 -33.91049 25.59262  1.000 29.99027 ? 8   PHE A HB3  1 
ATOM   129  H HD1  . PHE A 1 8   ? -11.92999 -33.37399 27.71080  1.000 37.92805 ? 8   PHE A HD1  1 
ATOM   130  H HD2  . PHE A 1 8   ? -12.55675 -31.07327 24.50327  1.000 33.93294 ? 8   PHE A HD2  1 
ATOM   131  H HE1  . PHE A 1 8   ? -13.69994 -32.35533 28.78703  1.000 42.03998 ? 8   PHE A HE1  1 
ATOM   132  H HE2  . PHE A 1 8   ? -14.31777 -30.05257 25.57511  1.000 36.91679 ? 8   PHE A HE2  1 
ATOM   133  H HZ   . PHE A 1 8   ? -14.89831 -30.69258 27.71695  1.000 37.16076 ? 8   PHE A HZ   1 
ATOM   134  N N    . PRO A 1 9   ? -7.96480  -34.16851 25.77484  1.000 27.48050 ? 9   PRO A N    1 
ATOM   135  C CA   . PRO A 1 9   ? -7.07728  -35.18346 25.20020  1.000 27.04480 ? 9   PRO A CA   1 
ATOM   136  C C    . PRO A 1 9   ? -7.79492  -35.92035 24.07963  1.000 24.98488 ? 9   PRO A C    1 
ATOM   137  O O    . PRO A 1 9   ? -8.97818  -36.24969 24.18667  1.000 30.91915 ? 9   PRO A O    1 
ATOM   138  C CB   . PRO A 1 9   ? -6.76152  -36.10041 26.38805  1.000 25.78447 ? 9   PRO A CB   1 
ATOM   139  C CG   . PRO A 1 9   ? -7.03934  -35.26985 27.59566  1.000 30.77128 ? 9   PRO A CG   1 
ATOM   140  C CD   . PRO A 1 9   ? -8.19249  -34.39196 27.21167  1.000 26.66637 ? 9   PRO A CD   1 
ATOM   141  H HA   . PRO A 1 9   ? -6.24884  -34.79812 24.87447  1.000 32.47654 ? 9   PRO A HA   1 
ATOM   142  H HB2  . PRO A 1 9   ? -7.33519  -36.88222 26.36416  1.000 30.96415 ? 9   PRO A HB2  1 
ATOM   143  H HB3  . PRO A 1 9   ? -5.83050  -36.37106 26.35876  1.000 30.96415 ? 9   PRO A HB3  1 
ATOM   144  H HG2  . PRO A 1 9   ? -7.27402  -35.84220 28.34281  1.000 36.94832 ? 9   PRO A HG2  1 
ATOM   145  H HG3  . PRO A 1 9   ? -6.25871  -34.73843 27.81724  1.000 36.94832 ? 9   PRO A HG3  1 
ATOM   146  H HD2  . PRO A 1 9   ? -9.03791  -34.84261 27.36355  1.000 32.02242 ? 9   PRO A HD2  1 
ATOM   147  H HD3  . PRO A 1 9   ? -8.17006  -33.55492 27.70133  1.000 32.02242 ? 9   PRO A HD3  1 
ATOM   148  N N    . SER A 1 10  ? -7.07058  -36.16436 22.99159  1.000 25.99368 ? 10  SER A N    1 
ATOM   149  C CA   . SER A 1 10  ? -7.67316  -36.58411 21.73316  1.000 26.24226 ? 10  SER A CA   1 
ATOM   150  C C    . SER A 1 10  ? -7.57582  -38.08115 21.47724  1.000 25.40745 ? 10  SER A C    1 
ATOM   151  O O    . SER A 1 10  ? -8.06384  -38.54699 20.44253  1.000 24.35938 ? 10  SER A O    1 
ATOM   152  C CB   . SER A 1 10  ? -7.02123  -35.82838 20.57092  1.000 25.44191 ? 10  SER A CB   1 
ATOM   153  O OG   . SER A 1 10  ? -5.61578  -36.01706 20.55562  1.000 28.19968 ? 10  SER A OG   1 
ATOM   154  H H    . SER A 1 10  ? -6.21426  -36.09222 22.95815  1.000 31.21520 ? 10  SER A H    1 
ATOM   155  H HA   . SER A 1 10  ? -8.61611  -36.35830 21.76047  1.000 31.51349 ? 10  SER A HA   1 
ATOM   156  H HB2  . SER A 1 10  ? -7.39092  -36.15691 19.73647  1.000 30.55307 ? 10  SER A HB2  1 
ATOM   157  H HB3  . SER A 1 10  ? -7.20960  -34.88175 20.66733  1.000 30.55307 ? 10  SER A HB3  1 
ATOM   158  H HG   . SER A 1 10  ? -5.29491  -35.72795 19.83516  1.000 33.86240 ? 10  SER A HG   1 
ATOM   159  N N    . GLY A 1 11  ? -6.98497  -38.84521 22.39734  1.000 27.02566 ? 11  GLY A N    1 
ATOM   160  C CA   . GLY A 1 11  ? -6.70365  -40.24549 22.11761  1.000 26.42555 ? 11  GLY A CA   1 
ATOM   161  C C    . GLY A 1 11  ? -7.93401  -41.03913 21.72248  1.000 26.56273 ? 11  GLY A C    1 
ATOM   162  O O    . GLY A 1 11  ? -7.89418  -41.83638 20.78189  1.000 28.83622 ? 11  GLY A O    1 
ATOM   163  H H    . GLY A 1 11  ? -6.74178  -38.57906 23.17812  1.000 32.45357 ? 11  GLY A H    1 
ATOM   164  H HA2  . GLY A 1 11  ? -6.06285  -40.30132 21.39156  1.000 31.73344 ? 11  GLY A HA2  1 
ATOM   165  H HA3  . GLY A 1 11  ? -6.32112  -40.65627 22.90871  1.000 31.73344 ? 11  GLY A HA3  1 
ATOM   166  N N    . LYS A 1 12  ? -9.04053  -40.84598 22.44048  1.000 26.12163 ? 12  LYS A N    1 
ATOM   167  C CA   . LYS A 1 12  ? -10.24123 -41.61809 22.14194  1.000 29.18709 ? 12  LYS A CA   1 
ATOM   168  C C    . LYS A 1 12  ? -10.75137 -41.34894 20.73191  1.000 27.96495 ? 12  LYS A C    1 
ATOM   169  O O    . LYS A 1 12  ? -11.33233 -42.24108 20.10347  1.000 28.52757 ? 12  LYS A O    1 
ATOM   170  C CB   . LYS A 1 12  ? -11.32677 -41.30881 23.16922  1.000 31.29853 ? 12  LYS A CB   1 
ATOM   171  C CG   . LYS A 1 12  ? -11.03534 -41.88583 24.55197  1.000 39.79755 ? 12  LYS A CG   1 
ATOM   172  C CD   . LYS A 1 12  ? -12.04072 -41.40566 25.58530  1.000 50.67456 ? 12  LYS A CD   1 
ATOM   173  C CE   . LYS A 1 12  ? -12.43038 -42.51773 26.55278  1.000 58.25279 ? 12  LYS A CE   1 
ATOM   174  N NZ   . LYS A 1 12  ? -11.24997 -43.17141 27.18307  1.000 52.93596 ? 12  LYS A NZ   1 
ATOM   175  H H    . LYS A 1 12  ? -9.11929  -40.28742 23.08965  1.000 31.36873 ? 12  LYS A H    1 
ATOM   176  H HA   . LYS A 1 12  ? -10.02767 -42.56231 22.20306  1.000 35.04728 ? 12  LYS A HA   1 
ATOM   177  H HB2  . LYS A 1 12  ? -11.40754 -40.34639 23.25934  1.000 37.58102 ? 12  LYS A HB2  1 
ATOM   178  H HB3  . LYS A 1 12  ? -12.16606 -41.68473 22.86072  1.000 37.58102 ? 12  LYS A HB3  1 
ATOM   179  H HG2  . LYS A 1 12  ? -11.08033 -42.85393 24.51117  1.000 47.77984 ? 12  LYS A HG2  1 
ATOM   180  H HG3  . LYS A 1 12  ? -10.15087 -41.60648 24.83583  1.000 47.77984 ? 12  LYS A HG3  1 
ATOM   181  H HD2  . LYS A 1 12  ? -11.65176 -40.67960 26.09760  1.000 60.83225 ? 12  LYS A HD2  1 
ATOM   182  H HD3  . LYS A 1 12  ? -12.84324 -41.10049 25.13393  1.000 60.83225 ? 12  LYS A HD3  1 
ATOM   183  H HE2  . LYS A 1 12  ? -12.97938 -42.14413 27.25983  1.000 69.92613 ? 12  LYS A HE2  1 
ATOM   184  H HE3  . LYS A 1 12  ? -12.92742 -43.19695 26.07060  1.000 69.92613 ? 12  LYS A HE3  1 
ATOM   185  H HZ1  . LYS A 1 12  ? -10.74829 -43.56042 26.55930  1.000 63.54593 ? 12  LYS A HZ1  1 
ATOM   186  H HZ2  . LYS A 1 12  ? -10.75923 -42.56528 27.61187  1.000 63.54593 ? 12  LYS A HZ2  1 
ATOM   187  H HZ3  . LYS A 1 12  ? -11.51860 -43.78936 27.76451  1.000 63.54593 ? 12  LYS A HZ3  1 
ATOM   188  N N    . VAL A 1 13  ? -10.55083 -40.13426 20.21985  1.000 23.87315 ? 13  VAL A N    1 
ATOM   189  C CA   . VAL A 1 13  ? -11.00571 -39.81075 18.87147  1.000 24.78236 ? 13  VAL A CA   1 
ATOM   190  C C    . VAL A 1 13  ? -9.98190  -40.25033 17.83145  1.000 24.88131 ? 13  VAL A C    1 
ATOM   191  O O    . VAL A 1 13  ? -10.34817 -40.69753 16.73767  1.000 23.47239 ? 13  VAL A O    1 
ATOM   192  C CB   . VAL A 1 13  ? -11.30519 -38.30485 18.76540  1.000 22.95866 ? 13  VAL A CB   1 
ATOM   193  C CG1  . VAL A 1 13  ? -11.66016 -37.92709 17.32952  1.000 31.21282 ? 13  VAL A CG1  1 
ATOM   194  C CG2  . VAL A 1 13  ? -12.42056 -37.92135 19.71271  1.000 23.61396 ? 13  VAL A CG2  1 
ATOM   195  H H    . VAL A 1 13  ? -10.15823 -39.48750 20.62872  1.000 28.67056 ? 13  VAL A H    1 
ATOM   196  H HA   . VAL A 1 13  ? -11.82742 -40.29700 18.70040  1.000 29.76160 ? 13  VAL A HA   1 
ATOM   197  H HB   . VAL A 1 13  ? -10.51097 -37.80796 19.01681  1.000 27.57317 ? 13  VAL A HB   1 
ATOM   198  H HG11 . VAL A 1 13  ? -10.86227 -37.98592 16.78105  1.000 37.47817 ? 13  VAL A HG11 1 
ATOM   199  H HG12 . VAL A 1 13  ? -12.33470 -38.54083 16.99906  1.000 37.47817 ? 13  VAL A HG12 1 
ATOM   200  H HG13 . VAL A 1 13  ? -12.00378 -37.02007 17.31734  1.000 37.47817 ? 13  VAL A HG13 1 
ATOM   201  H HG21 . VAL A 1 13  ? -12.14045 -38.10810 20.62242  1.000 28.35953 ? 13  VAL A HG21 1 
ATOM   202  H HG22 . VAL A 1 13  ? -12.60887 -36.97512 19.61224  1.000 28.35953 ? 13  VAL A HG22 1 
ATOM   203  H HG23 . VAL A 1 13  ? -13.21086 -38.44065 19.49674  1.000 28.35953 ? 13  VAL A HG23 1 
ATOM   204  N N    . GLU A 1 14  ? -8.68837  -40.11791 18.14538  1.000 22.18640 ? 14  GLU A N    1 
ATOM   205  C CA   . GLU A 1 14  ? -7.64537  -40.53118 17.20955  1.000 24.63153 ? 14  GLU A CA   1 
ATOM   206  C C    . GLU A 1 14  ? -7.88411  -41.94814 16.70384  1.000 27.32724 ? 14  GLU A C    1 
ATOM   207  O O    . GLU A 1 14  ? -7.67854  -42.23891 15.51929  1.000 22.62984 ? 14  GLU A O    1 
ATOM   208  C CB   . GLU A 1 14  ? -6.27049  -40.43491 17.87826  1.000 25.74152 ? 14  GLU A CB   1 
ATOM   209  C CG   . GLU A 1 14  ? -5.82974  -39.01509 18.20115  1.000 29.40901 ? 14  GLU A CG   1 
ATOM   210  C CD   . GLU A 1 14  ? -4.52308  -38.95703 18.97604  1.000 26.36425 ? 14  GLU A CD   1 
ATOM   211  O OE1  . GLU A 1 14  ? -3.59174  -39.71694 18.64482  1.000 30.62337 ? 14  GLU A OE1  1 
ATOM   212  O OE2  . GLU A 1 14  ? -4.42876  -38.14727 19.92133  1.000 34.50112 ? 14  GLU A OE2  1 
ATOM   213  H H    . GLU A 1 14  ? -8.39368  -39.79507 18.88601  1.000 26.64645 ? 14  GLU A H    1 
ATOM   214  H HA   . GLU A 1 14  ? -7.65636  -39.93025 16.44820  1.000 29.58061 ? 14  GLU A HA   1 
ATOM   215  H HB2  . GLU A 1 14  ? -6.29574  -40.93138 18.71119  1.000 30.91261 ? 14  GLU A HB2  1 
ATOM   216  H HB3  . GLU A 1 14  ? -5.60871  -40.81976 17.28258  1.000 30.91261 ? 14  GLU A HB3  1 
ATOM   217  H HG2  . GLU A 1 14  ? -5.70662  -38.52752 17.37168  1.000 35.31359 ? 14  GLU A HG2  1 
ATOM   218  H HG3  . GLU A 1 14  ? -6.51466  -38.58757 18.73875  1.000 35.31359 ? 14  GLU A HG3  1 
ATOM   219  N N    . GLY A 1 15  ? -8.31948  -42.84426 17.58817  1.000 22.47827 ? 15  GLY A N    1 
ATOM   220  C CA   . GLY A 1 15  ? -8.59237  -44.21803 17.21161  1.000 28.87813 ? 15  GLY A CA   1 
ATOM   221  C C    . GLY A 1 15  ? -9.80783  -44.41447 16.33168  1.000 30.13193 ? 15  GLY A C    1 
ATOM   222  O O    . GLY A 1 15  ? -10.06974 -45.54653 15.91542  1.000 28.14992 ? 15  GLY A O    1 
ATOM   223  H H    . GLY A 1 15  ? -8.46432  -42.67450 18.41871  1.000 26.99670 ? 15  GLY A H    1 
ATOM   224  H HA2  . GLY A 1 15  ? -7.82343  -44.56646 16.73388  1.000 34.67653 ? 15  GLY A HA2  1 
ATOM   225  H HA3  . GLY A 1 15  ? -8.72559  -44.73940 18.01866  1.000 34.67653 ? 15  GLY A HA3  1 
ATOM   226  N N    . CYS A 1 16  ? -10.55730 -43.35036 16.03660  1.000 26.21809 ? 16  CYS A N    1 
ATOM   227  C CA   . CYS A 1 16  ? -11.75360 -43.43716 15.21211  1.000 23.86824 ? 16  CYS A CA   1 
ATOM   228  C C    . CYS A 1 16  ? -11.57918 -42.81362 13.83190  1.000 23.35911 ? 16  CYS A C    1 
ATOM   229  O O    . CYS A 1 16  ? -12.48211 -42.93463 12.99940  1.000 19.70735 ? 16  CYS A O    1 
ATOM   230  C CB   . CYS A 1 16  ? -12.93555 -42.76398 15.92599  1.000 20.94500 ? 16  CYS A CB   1 
ATOM   231  S SG   . CYS A 1 16  ? -13.39201 -43.49204 17.51796  1.000 32.62243 ? 16  CYS A SG   1 
ATOM   232  H H    . CYS A 1 16  ? -10.38636 -42.55304 16.30984  1.000 31.48448 ? 16  CYS A H    1 
ATOM   233  H HA   . CYS A 1 16  ? -11.97827 -44.37226 15.08555  1.000 28.66467 ? 16  CYS A HA   1 
ATOM   234  H HB2  . CYS A 1 16  ? -12.70683 -41.83519 16.08701  1.000 25.15678 ? 16  CYS A HB2  1 
ATOM   235  H HB3  . CYS A 1 16  ? -13.71307 -42.81889 15.34862  1.000 25.15678 ? 16  CYS A HB3  1 
ATOM   236  H HG   . CYS A 1 16  ? -12.45359 -43.42282 18.26265  1.000 39.16969 ? 16  CYS A HG   1 
ATOM   237  N N    . MET A 1 17  ? -10.45033 -42.16204 13.55989  1.000 24.05793 ? 17  MET A N    1 
ATOM   238  C CA   . MET A 1 17  ? -10.25570 -41.46832 12.29241  1.000 22.50661 ? 17  MET A CA   1 
ATOM   239  C C    . MET A 1 17  ? -9.77843  -42.45062 11.22940  1.000 24.09910 ? 17  MET A C    1 
ATOM   240  O O    . MET A 1 17  ? -8.87492  -43.25646 11.47668  1.000 23.52407 ? 17  MET A O    1 
ATOM   241  C CB   . MET A 1 17  ? -9.25223  -40.32181 12.45244  1.000 30.99865 ? 17  MET A CB   1 
ATOM   242  C CG   . MET A 1 17  ? -9.65659  -39.28103 13.50694  1.000 26.23473 ? 17  MET A CG   1 
ATOM   243  S SD   . MET A 1 17  ? -11.39827 -38.78643 13.42750  1.000 24.89010 ? 17  MET A SD   1 
ATOM   244  C CE   . MET A 1 17  ? -11.49988 -38.13539 11.76004  1.000 27.96440 ? 17  MET A CE   1 
ATOM   245  H H    . MET A 1 17  ? -9.78005  -42.10741 14.09594  1.000 28.89229 ? 17  MET A H    1 
ATOM   246  H HA   . MET A 1 17  ? -11.09952 -41.08162 12.01075  1.000 27.03071 ? 17  MET A HA   1 
ATOM   247  H HB2  . MET A 1 17  ? -8.39590  -40.69275 12.71701  1.000 37.22116 ? 17  MET A HB2  1 
ATOM   248  H HB3  . MET A 1 17  ? -9.16649  -39.86271 11.60228  1.000 37.22116 ? 17  MET A HB3  1 
ATOM   249  H HG2  . MET A 1 17  ? -9.49607  -39.65280 14.38837  1.000 31.50445 ? 17  MET A HG2  1 
ATOM   250  H HG3  . MET A 1 17  ? -9.11822  -38.48421 13.37988  1.000 31.50445 ? 17  MET A HG3  1 
ATOM   251  H HE1  . MET A 1 17  ? -11.28807 -38.84300 11.13129  1.000 33.58005 ? 17  MET A HE1  1 
ATOM   252  H HE2  . MET A 1 17  ? -12.40028 -37.81104 11.60198  1.000 33.58005 ? 17  MET A HE2  1 
ATOM   253  H HE3  . MET A 1 17  ? -10.86500 -37.40812 11.66574  1.000 33.58005 ? 17  MET A HE3  1 
ATOM   254  N N    . VAL A 1 18  ? -10.40440 -42.39483 10.05222  1.000 26.45729 ? 18  VAL A N    1 
ATOM   255  C CA   . VAL A 1 18  ? -9.99713  -43.18626 8.89868   1.000 21.38907 ? 18  VAL A CA   1 
ATOM   256  C C    . VAL A 1 18  ? -10.02210 -42.28963 7.66740   1.000 25.92859 ? 18  VAL A C    1 
ATOM   257  O O    . VAL A 1 18  ? -10.52473 -41.16420 7.69367   1.000 23.81463 ? 18  VAL A O    1 
ATOM   258  C CB   . VAL A 1 18  ? -10.89474 -44.42629 8.68453   1.000 21.73794 ? 18  VAL A CB   1 
ATOM   259  C CG1  . VAL A 1 18  ? -10.92140 -45.28693 9.94756   1.000 26.59420 ? 18  VAL A CG1  1 
ATOM   260  C CG2  . VAL A 1 18  ? -12.30029 -44.00770 8.28485   1.000 25.22409 ? 18  VAL A CG2  1 
ATOM   261  H H    . VAL A 1 18  ? -11.08459 -41.89181 9.89758   1.000 31.77152 ? 18  VAL A H    1 
ATOM   262  H HA   . VAL A 1 18  ? -9.08772  -43.49635 9.03179   1.000 25.68967 ? 18  VAL A HA   1 
ATOM   263  H HB   . VAL A 1 18  ? -10.52767 -44.96037 7.96279   1.000 26.10831 ? 18  VAL A HB   1 
ATOM   264  H HG11 . VAL A 1 18  ? -10.13875 -45.08505 10.48385  1.000 31.93582 ? 18  VAL A HG11 1 
ATOM   265  H HG12 . VAL A 1 18  ? -11.72694 -45.08645 10.44938  1.000 31.93582 ? 18  VAL A HG12 1 
ATOM   266  H HG13 . VAL A 1 18  ? -10.91504 -46.22271 9.69225   1.000 31.93582 ? 18  VAL A HG13 1 
ATOM   267  H HG21 . VAL A 1 18  ? -12.26138 -43.54167 7.43503   1.000 30.29168 ? 18  VAL A HG21 1 
ATOM   268  H HG22 . VAL A 1 18  ? -12.85432 -44.79967 8.20273   1.000 30.29168 ? 18  VAL A HG22 1 
ATOM   269  H HG23 . VAL A 1 18  ? -12.66123 -43.42087 8.96768   1.000 30.29168 ? 18  VAL A HG23 1 
ATOM   270  N N    . GLN A 1 19  ? -9.46273  -42.80768 6.58181   1.000 26.11467 ? 19  GLN A N    1 
ATOM   271  C CA   . GLN A 1 19  ? -9.42457  -42.11660 5.30367   1.000 26.92778 ? 19  GLN A CA   1 
ATOM   272  C C    . GLN A 1 19  ? -10.50713 -42.67842 4.39519   1.000 24.93233 ? 19  GLN A C    1 
ATOM   273  O O    . GLN A 1 19  ? -10.69887 -43.89513 4.32342   1.000 23.63349 ? 19  GLN A O    1 
ATOM   274  C CB   . GLN A 1 19  ? -8.05153  -42.27839 4.65110   1.000 25.42861 ? 19  GLN A CB   1 
ATOM   275  C CG   . GLN A 1 19  ? -7.92149  -41.65628 3.27670   1.000 28.98187 ? 19  GLN A CG   1 
ATOM   276  C CD   . GLN A 1 19  ? -6.56043  -41.91652 2.66572   1.000 30.53185 ? 19  GLN A CD   1 
ATOM   277  O OE1  . GLN A 1 19  ? -5.69286  -41.04466 2.66566   1.000 32.42323 ? 19  GLN A OE1  1 
ATOM   278  N NE2  . GLN A 1 19  ? -6.36246  -43.12559 2.14897   1.000 30.98814 ? 19  GLN A NE2  1 
ATOM   279  H H    . GLN A 1 19  ? -9.08788  -43.58142 6.56145   1.000 31.36038 ? 19  GLN A H    1 
ATOM   280  H HA   . GLN A 1 19  ? -9.58978  -41.16898 5.42868   1.000 32.33611 ? 19  GLN A HA   1 
ATOM   281  H HB2  . GLN A 1 19  ? -7.38827  -41.86176 5.22330   1.000 30.53711 ? 19  GLN A HB2  1 
ATOM   282  H HB3  . GLN A 1 19  ? -7.86381  -43.22577 4.56091   1.000 30.53711 ? 19  GLN A HB3  1 
ATOM   283  H HG2  . GLN A 1 19  ? -8.59503  -42.03435 2.68991   1.000 34.80102 ? 19  GLN A HG2  1 
ATOM   284  H HG3  . GLN A 1 19  ? -8.04405  -40.69667 3.34752   1.000 34.80102 ? 19  GLN A HG3  1 
ATOM   285  H HE21 . GLN A 1 19  ? -6.99125  -43.71179 2.17315   1.000 37.20855 ? 19  GLN A HE21 1 
ATOM   286  H HE22 . GLN A 1 19  ? -5.60561  -43.32138 1.79057   1.000 37.20855 ? 19  GLN A HE22 1 
ATOM   287  N N    . VAL A 1 20  ? -11.21284 -41.78921 3.70321   1.000 22.98019 ? 20  VAL A N    1 
ATOM   288  C CA   . VAL A 1 20  ? -12.26785 -42.17588 2.77372   1.000 23.60188 ? 20  VAL A CA   1 
ATOM   289  C C    . VAL A 1 20  ? -11.96561 -41.52761 1.43340   1.000 24.81571 ? 20  VAL A C    1 
ATOM   290  O O    . VAL A 1 20  ? -11.83541 -40.29997 1.34828   1.000 25.23242 ? 20  VAL A O    1 
ATOM   291  C CB   . VAL A 1 20  ? -13.66400 -41.76584 3.26938   1.000 21.08966 ? 20  VAL A CB   1 
ATOM   292  C CG1  . VAL A 1 20  ? -14.72516 -42.16901 2.25339   1.000 25.44365 ? 20  VAL A CG1  1 
ATOM   293  C CG2  . VAL A 1 20  ? -13.94586 -42.39135 4.61824   1.000 26.70539 ? 20  VAL A CG2  1 
ATOM   294  H H    . VAL A 1 20  ? -11.09582 -40.93890 3.75690   1.000 27.59901 ? 20  VAL A H    1 
ATOM   295  H HA   . VAL A 1 20  ? -12.25827 -43.13939 2.66212   1.000 28.34503 ? 20  VAL A HA   1 
ATOM   296  H HB   . VAL A 1 20  ? -13.69622 -40.80176 3.37145   1.000 25.33036 ? 20  VAL A HB   1 
ATOM   297  H HG11 . VAL A 1 20  ? -14.33024 -42.77644 1.60843   1.000 30.55516 ? 20  VAL A HG11 1 
ATOM   298  H HG12 . VAL A 1 20  ? -15.45558 -42.60782 2.71689   1.000 30.55516 ? 20  VAL A HG12 1 
ATOM   299  H HG13 . VAL A 1 20  ? -15.04958 -41.37351 1.80302   1.000 30.55516 ? 20  VAL A HG13 1 
ATOM   300  H HG21 . VAL A 1 20  ? -14.87695 -42.24353 4.84653   1.000 32.06924 ? 20  VAL A HG21 1 
ATOM   301  H HG22 . VAL A 1 20  ? -13.76436 -43.34295 4.56918   1.000 32.06924 ? 20  VAL A HG22 1 
ATOM   302  H HG23 . VAL A 1 20  ? -13.37272 -41.97915 5.28345   1.000 32.06924 ? 20  VAL A HG23 1 
ATOM   303  N N    . THR A 1 21  ? -11.85305 -42.34630 0.39253   1.000 22.52391 ? 21  THR A N    1 
ATOM   304  C CA   . THR A 1 21  ? -11.54410 -41.87672 -0.94864  1.000 25.18379 ? 21  THR A CA   1 
ATOM   305  C C    . THR A 1 21  ? -12.62285 -42.34292 -1.91552  1.000 27.86894 ? 21  THR A C    1 
ATOM   306  O O    . THR A 1 21  ? -13.02152 -43.51241 -1.89901  1.000 26.47430 ? 21  THR A O    1 
ATOM   307  C CB   . THR A 1 21  ? -10.17285 -42.38846 -1.41284  1.000 29.52676 ? 21  THR A CB   1 
ATOM   308  O OG1  . THR A 1 21  ? -9.16229  -41.99837 -0.47260  1.000 25.15618 ? 21  THR A OG1  1 
ATOM   309  C CG2  . THR A 1 21  ? -9.83156  -41.84076 -2.79674  1.000 29.13851 ? 21  THR A CG2  1 
ATOM   310  H H    . THR A 1 21  ? -11.95430 -43.19887 0.44228   1.000 27.05147 ? 21  THR A H    1 
ATOM   311  H HA   . THR A 1 21  ? -11.53073 -40.90681 -0.94918  1.000 30.24333 ? 21  THR A HA   1 
ATOM   312  H HB   . THR A 1 21  ? -10.19437 -43.35653 -1.47000  1.000 35.45489 ? 21  THR A HB   1 
ATOM   313  H HG1  . THR A 1 21  ? -8.42820  -42.35209 -0.67655  1.000 30.21019 ? 21  THR A HG1  1 
ATOM   314  H HG21 . THR A 1 21  ? -10.02471 -40.89093 -2.83451  1.000 34.98899 ? 21  THR A HG21 1 
ATOM   315  H HG22 . THR A 1 21  ? -8.89000  -41.97827 -2.98502  1.000 34.98899 ? 21  THR A HG22 1 
ATOM   316  H HG23 . THR A 1 21  ? -10.35754 -42.29608 -3.47271  1.000 34.98899 ? 21  THR A HG23 1 
ATOM   317  N N    . CYS A 1 22  ? -13.08157 -41.42880 -2.76559  1.000 27.58829 ? 22  CYS A N    1 
ATOM   318  C CA   . CYS A 1 22  ? -14.07131 -41.73453 -3.79491  1.000 30.04903 ? 22  CYS A CA   1 
ATOM   319  C C    . CYS A 1 22  ? -13.57943 -41.08735 -5.08063  1.000 33.54820 ? 22  CYS A C    1 
ATOM   320  O O    . CYS A 1 22  ? -13.52019 -39.85691 -5.17337  1.000 30.96479 ? 22  CYS A O    1 
ATOM   321  C CB   . CYS A 1 22  ? -15.46136 -41.22533 -3.40855  1.000 27.36167 ? 22  CYS A CB   1 
ATOM   322  S SG   . CYS A 1 22  ? -16.81687 -42.05275 -4.27053  1.000 37.59080 ? 22  CYS A SG   1 
ATOM   323  H H    . CYS A 1 22  ? -12.82906 -40.60670 -2.76586  1.000 33.12873 ? 22  CYS A H    1 
ATOM   324  H HA   . CYS A 1 22  ? -14.14084 -42.69346 -3.92346  1.000 36.08162 ? 22  CYS A HA   1 
ATOM   325  H HB2  . CYS A 1 22  ? -15.58912 -41.36380 -2.45702  1.000 32.85678 ? 22  CYS A HB2  1 
ATOM   326  H HB3  . CYS A 1 22  ? -15.51402 -40.27928 -3.61615  1.000 32.85678 ? 22  CYS A HB3  1 
ATOM   327  H HG   . CYS A 1 22  ? -16.65262 -41.94204 -5.45407  1.000 45.13174 ? 22  CYS A HG   1 
ATOM   328  N N    . GLY A 1 23  ? -13.21237 -41.90884 -6.05983  1.000 31.93483 ? 23  GLY A N    1 
ATOM   329  C CA   . GLY A 1 23  ? -12.51785 -41.40886 -7.22754  1.000 34.69334 ? 23  GLY A CA   1 
ATOM   330  C C    . GLY A 1 23  ? -11.24245 -40.69270 -6.83721  1.000 35.43362 ? 23  GLY A C    1 
ATOM   331  O O    . GLY A 1 23  ? -10.30384 -41.31194 -6.32653  1.000 37.29375 ? 23  GLY A O    1 
ATOM   332  H H    . GLY A 1 23  ? -13.35602 -42.75673 -6.06658  1.000 38.34458 ? 23  GLY A H    1 
ATOM   333  H HA2  . GLY A 1 23  ? -12.29304 -42.14780 -7.81434  1.000 41.65478 ? 23  GLY A HA2  1 
ATOM   334  H HA3  . GLY A 1 23  ? -13.08957 -40.78830 -7.70600  1.000 41.65478 ? 23  GLY A HA3  1 
ATOM   335  N N    . THR A 1 24  ? -11.20768 -39.37885 -7.05133  1.000 34.56823 ? 24  THR A N    1 
ATOM   336  C CA   . THR A 1 24  ? -10.02487 -38.57557 -6.78061  1.000 38.35025 ? 24  THR A CA   1 
ATOM   337  C C    . THR A 1 24  ? -10.14635 -37.72550 -5.52139  1.000 33.31350 ? 24  THR A C    1 
ATOM   338  O O    . THR A 1 24  ? -9.16341  -37.08662 -5.12956  1.000 36.52230 ? 24  THR A O    1 
ATOM   339  C CB   . THR A 1 24  ? -9.72275  -37.66427 -7.98248  1.000 43.88634 ? 24  THR A CB   1 
ATOM   340  O OG1  . THR A 1 24  ? -8.61678  -36.80590 -7.67619  1.000 58.86504 ? 24  THR A OG1  1 
ATOM   341  C CG2  . THR A 1 24  ? -10.93632 -36.81593 -8.34318  1.000 40.97182 ? 24  THR A CG2  1 
ATOM   342  H H    . THR A 1 24  ? -11.87005 -38.92446 -7.35856  1.000 41.50466 ? 24  THR A H    1 
ATOM   343  H HA   . THR A 1 24  ? -9.26644  -39.16796 -6.65911  1.000 46.04307 ? 24  THR A HA   1 
ATOM   344  H HB   . THR A 1 24  ? -9.50094  -38.21550 -8.74919  1.000 52.68639 ? 24  THR A HB   1 
ATOM   345  H HG1  . THR A 1 24  ? -7.90294  -37.24860 -7.66884  1.000 70.66082 ? 24  THR A HG1  1 
ATOM   346  H HG21 . THR A 1 24  ? -11.63026 -37.37533 -8.72582  1.000 49.18896 ? 24  THR A HG21 1 
ATOM   347  H HG22 . THR A 1 24  ? -11.28475 -36.38085 -7.54932  1.000 49.18896 ? 24  THR A HG22 1 
ATOM   348  H HG23 . THR A 1 24  ? -10.68650 -36.13757 -8.98995  1.000 49.18896 ? 24  THR A HG23 1 
ATOM   349  N N    . THR A 1 25  ? -11.31159 -37.69897 -4.87925  1.000 33.05886 ? 25  THR A N    1 
ATOM   350  C CA   . THR A 1 25  ? -11.51591 -36.89659 -3.67975  1.000 28.49472 ? 25  THR A CA   1 
ATOM   351  C C    . THR A 1 25  ? -11.24226 -37.73433 -2.43566  1.000 28.43522 ? 25  THR A C    1 
ATOM   352  O O    . THR A 1 25  ? -11.77061 -38.84207 -2.29623  1.000 29.37652 ? 25  THR A O    1 
ATOM   353  C CB   . THR A 1 25  ? -12.94206 -36.34639 -3.64425  1.000 26.61989 ? 25  THR A CB   1 
ATOM   354  O OG1  . THR A 1 25  ? -13.24782 -35.73816 -4.90552  1.000 29.15950 ? 25  THR A OG1  1 
ATOM   355  C CG2  . THR A 1 25  ? -13.09698 -35.31114 -2.53256  1.000 31.24412 ? 25  THR A CG2  1 
ATOM   356  H H    . THR A 1 25  ? -12.00663 -38.14303 -5.12284  1.000 39.69341 ? 25  THR A H    1 
ATOM   357  H HA   . THR A 1 25  ? -10.89665 -36.15000 -3.68255  1.000 34.21645 ? 25  THR A HA   1 
ATOM   358  H HB   . THR A 1 25  ? -13.56353 -37.07064 -3.47065  1.000 31.96664 ? 25  THR A HB   1 
ATOM   359  H HG1  . THR A 1 25  ? -12.62180 -35.22863 -5.13804  1.000 35.01417 ? 25  THR A HG1  1 
ATOM   360  H HG21 . THR A 1 25  ? -12.47669 -35.50288 -1.81188  1.000 37.51573 ? 25  THR A HG21 1 
ATOM   361  H HG22 . THR A 1 25  ? -12.91357 -34.42347 -2.87795  1.000 37.51573 ? 25  THR A HG22 1 
ATOM   362  H HG23 . THR A 1 25  ? -14.00165 -35.33230 -2.18324  1.000 37.51573 ? 25  THR A HG23 1 
ATOM   363  N N    . THR A 1 26  ? -10.42549 -37.19692 -1.53016  1.000 27.41377 ? 26  THR A N    1 
ATOM   364  C CA   . THR A 1 26  ? -10.07002 -37.87501 -0.29099  1.000 28.93630 ? 26  THR A CA   1 
ATOM   365  C C    . THR A 1 26  ? -10.32249 -36.94072 0.88239   1.000 26.41974 ? 26  THR A C    1 
ATOM   366  O O    . THR A 1 26  ? -9.92601  -35.77087 0.85043   1.000 26.36110 ? 26  THR A O    1 
ATOM   367  C CB   . THR A 1 26  ? -8.60358  -38.33200 -0.30392  1.000 29.24090 ? 26  THR A CB   1 
ATOM   368  O OG1  . THR A 1 26  ? -8.42853  -39.35610 -1.28987  1.000 35.82487 ? 26  THR A OG1  1 
ATOM   369  C CG2  . THR A 1 26  ? -8.19811  -38.88673 1.05262   1.000 31.19837 ? 26  THR A CG2  1 
ATOM   370  H H    . THR A 1 26  ? -10.05849 -36.42389 -1.61583  1.000 32.91930 ? 26  THR A H    1 
ATOM   371  H HA   . THR A 1 26  ? -10.63065 -38.65892 -0.18106  1.000 34.74634 ? 26  THR A HA   1 
ATOM   372  H HB   . THR A 1 26  ? -8.03666  -37.57242 -0.51016  1.000 35.11186 ? 26  THR A HB   1 
ATOM   373  H HG1  . THR A 1 26  ? -8.59913  -39.05152 -2.05389  1.000 43.01262 ? 26  THR A HG1  1 
ATOM   374  H HG21 . THR A 1 26  ? -7.32978  -39.31450 0.99004   1.000 37.46082 ? 26  THR A HG21 1 
ATOM   375  H HG22 . THR A 1 26  ? -8.14934  -38.16909 1.70340   1.000 37.46082 ? 26  THR A HG22 1 
ATOM   376  H HG23 . THR A 1 26  ? -8.84984  -39.53969 1.35230   1.000 37.46082 ? 26  THR A HG23 1 
ATOM   377  N N    . LEU A 1 27  ? -10.99847 -37.45280 1.90384   1.000 24.89594 ? 27  LEU A N    1 
ATOM   378  C CA   . LEU A 1 27  ? -11.18722 -36.71895 3.14482   1.000 22.93035 ? 27  LEU A CA   1 
ATOM   379  C C    . LEU A 1 27  ? -11.21830 -37.72857 4.28677   1.000 23.23722 ? 27  LEU A C    1 
ATOM   380  O O    . LEU A 1 27  ? -10.85321 -38.89525 4.11493   1.000 24.27354 ? 27  LEU A O    1 
ATOM   381  C CB   . LEU A 1 27  ? -12.44704 -35.84916 3.05691   1.000 23.98406 ? 27  LEU A CB   1 
ATOM   382  C CG   . LEU A 1 27  ? -13.75951 -36.52602 2.66693   1.000 25.92726 ? 27  LEU A CG   1 
ATOM   383  C CD1  . LEU A 1 27  ? -14.30816 -37.34193 3.81830   1.000 28.60859 ? 27  LEU A CD1  1 
ATOM   384  C CD2  . LEU A 1 27  ? -14.77366 -35.48375 2.22024   1.000 27.32449 ? 27  LEU A CD2  1 
ATOM   385  H H    . LEU A 1 27  ? -11.36098 -38.23266 1.90089   1.000 29.89790 ? 27  LEU A H    1 
ATOM   386  H HA   . LEU A 1 27  ? -10.43244 -36.12896 3.29689   1.000 27.53920 ? 27  LEU A HA   1 
ATOM   387  H HB2  . LEU A 1 27  ? -12.58897 -35.44738 3.92831   1.000 28.80365 ? 27  LEU A HB2  1 
ATOM   388  H HB3  . LEU A 1 27  ? -12.28262 -35.15852 2.39595   1.000 28.80365 ? 27  LEU A HB3  1 
ATOM   389  H HG   . LEU A 1 27  ? -13.59531 -37.13195 1.92748   1.000 31.13549 ? 27  LEU A HG   1 
ATOM   390  H HD11 . LEU A 1 27  ? -14.26282 -36.81290 4.63007   1.000 34.35309 ? 27  LEU A HD11 1 
ATOM   391  H HD12 . LEU A 1 27  ? -15.22973 -37.57711 3.62778   1.000 34.35309 ? 27  LEU A HD12 1 
ATOM   392  H HD13 . LEU A 1 27  ? -13.77523 -38.14632 3.91750   1.000 34.35309 ? 27  LEU A HD13 1 
ATOM   393  H HD21 . LEU A 1 27  ? -14.38246 -34.94425 1.51540   1.000 32.81216 ? 27  LEU A HD21 1 
ATOM   394  H HD22 . LEU A 1 27  ? -15.56605 -35.93536 1.89000   1.000 32.81216 ? 27  LEU A HD22 1 
ATOM   395  H HD23 . LEU A 1 27  ? -15.00403 -34.92257 2.97715   1.000 32.81216 ? 27  LEU A HD23 1 
ATOM   396  N N    . ASN A 1 28  ? -11.65159 -37.28212 5.45961   1.000 23.66022 ? 28  ASN A N    1 
ATOM   397  C CA   . ASN A 1 28  ? -11.62689 -38.11267 6.65244   1.000 19.16332 ? 28  ASN A CA   1 
ATOM   398  C C    . ASN A 1 28  ? -13.02240 -38.62804 6.97554   1.000 24.41039 ? 28  ASN A C    1 
ATOM   399  O O    . ASN A 1 28  ? -14.03044 -38.00029 6.64497   1.000 21.28107 ? 28  ASN A O    1 
ATOM   400  C CB   . ASN A 1 28  ? -11.07330 -37.33065 7.84333   1.000 21.63864 ? 28  ASN A CB   1 
ATOM   401  C CG   . ASN A 1 28  ? -9.77880  -36.61587 7.51314   1.000 22.93263 ? 28  ASN A CG   1 
ATOM   402  O OD1  . ASN A 1 28  ? -8.69865  -37.20244 7.58201   1.000 21.98284 ? 28  ASN A OD1  1 
ATOM   403  N ND2  . ASN A 1 28  ? -9.88153  -35.34214 7.14123   1.000 25.90247 ? 28  ASN A ND2  1 
ATOM   404  H H    . ASN A 1 28  ? -11.96750 -36.49278 5.58900   1.000 28.41505 ? 28  ASN A H    1 
ATOM   405  H HA   . ASN A 1 28  ? -11.05346 -38.87944 6.49707   1.000 23.01877 ? 28  ASN A HA   1 
ATOM   406  H HB2  . ASN A 1 28  ? -11.72403 -36.66509 8.11625   1.000 25.98915 ? 28  ASN A HB2  1 
ATOM   407  H HB3  . ASN A 1 28  ? -10.90062 -37.94492 8.57391   1.000 25.98915 ? 28  ASN A HB3  1 
ATOM   408  H HD21 . ASN A 1 28  ? -9.17491  -34.89359 6.94352   1.000 31.10574 ? 28  ASN A HD21 1 
ATOM   409  H HD22 . ASN A 1 28  ? -10.65452 -34.96763 7.09861   1.000 31.10574 ? 28  ASN A HD22 1 
ATOM   410  N N    . GLY A 1 29  ? -13.06711 -39.79798 7.61201   1.000 22.52896 ? 29  GLY A N    1 
ATOM   411  C CA   . GLY A 1 29  ? -14.30360 -40.32874 8.13445   1.000 27.12619 ? 29  GLY A CA   1 
ATOM   412  C C    . GLY A 1 29  ? -14.14187 -40.71013 9.59291   1.000 23.59000 ? 29  GLY A C    1 
ATOM   413  O O    . GLY A 1 29  ? -13.03081 -40.84930 10.10357  1.000 19.99894 ? 29  GLY A O    1 
ATOM   414  H H    . GLY A 1 29  ? -12.38365 -40.30120 7.75076   1.000 27.05753 ? 29  GLY A H    1 
ATOM   415  H HA2  . GLY A 1 29  ? -15.00482 -39.66261 8.06045   1.000 32.57420 ? 29  GLY A HA2  1 
ATOM   416  H HA3  . GLY A 1 29  ? -14.56209 -41.11661 7.63113   1.000 32.57420 ? 29  GLY A HA3  1 
ATOM   417  N N    . LEU A 1 30  ? -15.28210 -40.87118 10.26057  1.000 23.81298 ? 30  LEU A N    1 
ATOM   418  C CA   . LEU A 1 30  ? -15.33240 -41.23412 11.67175  1.000 22.30063 ? 30  LEU A CA   1 
ATOM   419  C C    . LEU A 1 30  ? -15.87663 -42.65128 11.78762  1.000 20.54783 ? 30  LEU A C    1 
ATOM   420  O O    . LEU A 1 30  ? -17.03287 -42.90889 11.43327  1.000 20.72282 ? 30  LEU A O    1 
ATOM   421  C CB   . LEU A 1 30  ? -16.19814 -40.25190 12.46069  1.000 23.46720 ? 30  LEU A CB   1 
ATOM   422  C CG   . LEU A 1 30  ? -16.30887 -40.50346 13.96635  1.000 22.31740 ? 30  LEU A CG   1 
ATOM   423  C CD1  . LEU A 1 30  ? -15.03815 -40.08896 14.68414  1.000 24.77162 ? 30  LEU A CD1  1 
ATOM   424  C CD2  . LEU A 1 30  ? -17.51509 -39.77242 14.53099  1.000 23.64137 ? 30  LEU A CD2  1 
ATOM   425  H H    . LEU A 1 30  ? -16.05950 -40.77253 9.90630   1.000 28.59835 ? 30  LEU A H    1 
ATOM   426  H HA   . LEU A 1 30  ? -14.43818 -41.21541 12.04715  1.000 26.78353 ? 30  LEU A HA   1 
ATOM   427  H HB2  . LEU A 1 30  ? -15.82648 -39.36331 12.34586  1.000 28.18342 ? 30  LEU A HB2  1 
ATOM   428  H HB3  . LEU A 1 30  ? -17.09736 -40.28476 12.09845  1.000 28.18342 ? 30  LEU A HB3  1 
ATOM   429  H HG   . LEU A 1 30  ? -16.42934 -41.45358 14.12015  1.000 26.80365 ? 30  LEU A HG   1 
ATOM   430  H HD11 . LEU A 1 30  ? -15.03814 -40.47445 15.57425  1.000 29.74872 ? 30  LEU A HD11 1 
ATOM   431  H HD12 . LEU A 1 30  ? -14.27283 -40.41243 14.18358  1.000 29.74872 ? 30  LEU A HD12 1 
ATOM   432  H HD13 . LEU A 1 30  ? -15.00994 -39.12114 14.74282  1.000 29.74872 ? 30  LEU A HD13 1 
ATOM   433  H HD21 . LEU A 1 30  ? -18.32301 -40.17427 14.17507  1.000 28.39242 ? 30  LEU A HD21 1 
ATOM   434  H HD22 . LEU A 1 30  ? -17.50620 -39.84832 15.49798  1.000 28.39242 ? 30  LEU A HD22 1 
ATOM   435  H HD23 . LEU A 1 30  ? -17.46825 -38.83880 14.27204  1.000 28.39242 ? 30  LEU A HD23 1 
ATOM   436  N N    . TRP A 1 31  ? -15.04475 -43.55745 12.29359  1.000 21.03183 ? 31  TRP A N    1 
ATOM   437  C CA   . TRP A 1 31  ? -15.34380 -44.98520 12.34194  1.000 20.96242 ? 31  TRP A CA   1 
ATOM   438  C C    . TRP A 1 31  ? -15.80421 -45.34769 13.74984  1.000 22.19788 ? 31  TRP A C    1 
ATOM   439  O O    . TRP A 1 31  ? -14.99579 -45.39522 14.68299  1.000 22.87011 ? 31  TRP A O    1 
ATOM   440  C CB   . TRP A 1 31  ? -14.11237 -45.79263 11.94005  1.000 24.67110 ? 31  TRP A CB   1 
ATOM   441  C CG   . TRP A 1 31  ? -14.32116 -47.28635 11.89664  1.000 24.30712 ? 31  TRP A CG   1 
ATOM   442  C CD1  . TRP A 1 31  ? -15.51079 -47.95639 11.80606  1.000 27.00275 ? 31  TRP A CD1  1 
ATOM   443  C CD2  . TRP A 1 31  ? -13.30021 -48.28973 11.93614  1.000 26.11437 ? 31  TRP A CD2  1 
ATOM   444  N NE1  . TRP A 1 31  ? -15.28945 -49.31477 11.78711  1.000 26.48804 ? 31  TRP A NE1  1 
ATOM   445  C CE2  . TRP A 1 31  ? -13.94091 -49.54437 11.86483  1.000 28.02940 ? 31  TRP A CE2  1 
ATOM   446  C CE3  . TRP A 1 31  ? -11.90591 -48.24874 12.02555  1.000 28.09183 ? 31  TRP A CE3  1 
ATOM   447  C CZ2  . TRP A 1 31  ? -13.23519 -50.74316 11.88341  1.000 29.11009 ? 31  TRP A CZ2  1 
ATOM   448  C CZ3  . TRP A 1 31  ? -11.20715 -49.44029 12.04230  1.000 28.76526 ? 31  TRP A CZ3  1 
ATOM   449  C CH2  . TRP A 1 31  ? -11.87184 -50.67093 11.97164  1.000 30.09185 ? 31  TRP A CH2  1 
ATOM   450  H H    . TRP A 1 31  ? -14.27575 -43.36274 12.62576  1.000 25.26098 ? 31  TRP A H    1 
ATOM   451  H HA   . TRP A 1 31  ? -16.06820 -45.18735 11.72934  1.000 25.17768 ? 31  TRP A HA   1 
ATOM   452  H HB2  . TRP A 1 31  ? -13.83537 -45.51116 11.05408  1.000 29.62810 ? 31  TRP A HB2  1 
ATOM   453  H HB3  . TRP A 1 31  ? -13.40568 -45.61559 12.58047  1.000 29.62810 ? 31  TRP A HB3  1 
ATOM   454  H HD1  . TRP A 1 31  ? -16.34746 -47.55258 11.76347  1.000 32.42607 ? 31  TRP A HD1  1 
ATOM   455  H HE1  . TRP A 1 31  ? -15.89796 -49.92025 11.73501  1.000 31.80843 ? 31  TRP A HE1  1 
ATOM   456  H HE3  . TRP A 1 31  ? -11.45749 -47.43536 12.07282  1.000 33.73298 ? 31  TRP A HE3  1 
ATOM   457  H HZ2  . TRP A 1 31  ? -13.67338 -51.56219 11.83761  1.000 34.95489 ? 31  TRP A HZ2  1 
ATOM   458  H HZ3  . TRP A 1 31  ? -10.27917 -49.42496 12.10155  1.000 34.54109 ? 31  TRP A HZ3  1 
ATOM   459  H HH2  . TRP A 1 31  ? -11.37511 -51.45705 11.98499  1.000 36.13300 ? 31  TRP A HH2  1 
ATOM   460  N N    . LEU A 1 32  ? -17.10316 -45.60187 13.89699  1.000 23.20426 ? 32  LEU A N    1 
ATOM   461  C CA   . LEU A 1 32  ? -17.70843 -45.97196 15.17030  1.000 24.92981 ? 32  LEU A CA   1 
ATOM   462  C C    . LEU A 1 32  ? -18.56644 -47.20868 14.95999  1.000 26.17639 ? 32  LEU A C    1 
ATOM   463  O O    . LEU A 1 32  ? -19.39761 -47.23701 14.04745  1.000 22.56861 ? 32  LEU A O    1 
ATOM   464  C CB   . LEU A 1 32  ? -18.57056 -44.83891 15.73148  1.000 26.59730 ? 32  LEU A CB   1 
ATOM   465  C CG   . LEU A 1 32  ? -17.86306 -43.53448 16.09683  1.000 24.06896 ? 32  LEU A CG   1 
ATOM   466  C CD1  . LEU A 1 32  ? -18.89060 -42.45011 16.32753  1.000 28.86788 ? 32  LEU A CD1  1 
ATOM   467  C CD2  . LEU A 1 32  ? -16.98865 -43.71136 17.32987  1.000 24.43608 ? 32  LEU A CD2  1 
ATOM   468  H H    . LEU A 1 32  ? -17.67060 -45.56471 13.25182  1.000 27.86789 ? 32  LEU A H    1 
ATOM   469  H HA   . LEU A 1 32  ? -17.01008 -46.17312 15.81275  1.000 29.93855 ? 32  LEU A HA   1 
ATOM   470  H HB2  . LEU A 1 32  ? -19.24148 -44.61859 15.06648  1.000 31.93953 ? 32  LEU A HB2  1 
ATOM   471  H HB3  . LEU A 1 32  ? -18.99825 -45.16308 16.53950  1.000 31.93953 ? 32  LEU A HB3  1 
ATOM   472  H HG   . LEU A 1 32  ? -17.28263 -43.26997 15.36605  1.000 28.90553 ? 32  LEU A HG   1 
ATOM   473  H HD11 . LEU A 1 32  ? -19.48745 -42.72709 17.04023  1.000 34.66424 ? 32  LEU A HD11 1 
ATOM   474  H HD12 . LEU A 1 32  ? -18.43480 -41.63112 16.57733  1.000 34.66424 ? 32  LEU A HD12 1 
ATOM   475  H HD13 . LEU A 1 32  ? -19.39356 -42.31249 15.50961  1.000 34.66424 ? 32  LEU A HD13 1 
ATOM   476  H HD21 . LEU A 1 32  ? -17.53044 -43.57692 18.12315  1.000 29.34607 ? 32  LEU A HD21 1 
ATOM   477  H HD22 . LEU A 1 32  ? -16.61977 -44.60848 17.32937  1.000 29.34607 ? 32  LEU A HD22 1 
ATOM   478  H HD23 . LEU A 1 32  ? -16.27143 -43.05878 17.30465  1.000 29.34607 ? 32  LEU A HD23 1 
ATOM   479  N N    . ASP A 1 33  ? -18.39252 -48.21388 15.81820  1.000 26.10335 ? 33  ASP A N    1 
ATOM   480  C CA   . ASP A 1 33  ? -19.03800 -49.50059 15.58583  1.000 28.94543 ? 33  ASP A CA   1 
ATOM   481  C C    . ASP A 1 33  ? -18.69626 -49.94836 14.16636  1.000 28.25749 ? 33  ASP A C    1 
ATOM   482  O O    . ASP A 1 33  ? -17.53927 -49.83443 13.74796  1.000 24.57553 ? 33  ASP A O    1 
ATOM   483  C CB   . ASP A 1 33  ? -20.55094 -49.40037 15.80865  1.000 28.72715 ? 33  ASP A CB   1 
ATOM   484  C CG   . ASP A 1 33  ? -20.90877 -48.96877 17.22603  1.000 39.16314 ? 33  ASP A CG   1 
ATOM   485  O OD1  . ASP A 1 33  ? -20.05946 -49.12354 18.12810  1.000 38.81889 ? 33  ASP A OD1  1 
ATOM   486  O OD2  . ASP A 1 33  ? -22.04067 -48.48171 17.44094  1.000 37.12184 ? 33  ASP A OD2  1 
ATOM   487  H H    . ASP A 1 33  ? -17.91260 -48.17440 16.53074  1.000 31.34680 ? 33  ASP A H    1 
ATOM   488  H HA   . ASP A 1 33  ? -18.72400 -50.17002 16.21365  1.000 34.75729 ? 33  ASP A HA   1 
ATOM   489  H HB2  . ASP A 1 33  ? -20.91870 -48.74648 15.19376  1.000 34.49535 ? 33  ASP A HB2  1 
ATOM   490  H HB3  . ASP A 1 33  ? -20.95253 -50.26873 15.64876  1.000 34.49535 ? 33  ASP A HB3  1 
ATOM   491  N N    . ASP A 1 34  ? -19.67656 -50.43732 13.40464  1.000 27.55135 ? 34  ASP A N    1 
ATOM   492  C CA   . ASP A 1 34  ? -19.44091 -50.86205 12.02861  1.000 27.45666 ? 34  ASP A CA   1 
ATOM   493  C C    . ASP A 1 34  ? -19.90570 -49.82374 11.01079  1.000 27.40109 ? 34  ASP A C    1 
ATOM   494  O O    . ASP A 1 34  ? -20.34881 -50.18281 9.91464   1.000 27.63809 ? 34  ASP A O    1 
ATOM   495  C CB   . ASP A 1 34  ? -20.11582 -52.20951 11.76550  1.000 29.29675 ? 34  ASP A CB   1 
ATOM   496  C CG   . ASP A 1 34  ? -21.62324 -52.16248 11.94397  1.000 34.83245 ? 34  ASP A CG   1 
ATOM   497  O OD1  . ASP A 1 34  ? -22.14990 -51.12339 12.39960  1.000 32.55285 ? 34  ASP A OD1  1 
ATOM   498  O OD2  . ASP A 1 34  ? -22.28312 -53.17617 11.62659  1.000 32.64042 ? 34  ASP A OD2  1 
ATOM   499  H H    . ASP A 1 34  ? -20.49016 -50.53209 13.66670  1.000 33.08440 ? 34  ASP A H    1 
ATOM   500  H HA   . ASP A 1 34  ? -18.48578 -50.97919 11.90653  1.000 32.97077 ? 34  ASP A HA   1 
ATOM   501  H HB2  . ASP A 1 34  ? -19.93113 -52.48175 10.85299  1.000 35.17887 ? 34  ASP A HB2  1 
ATOM   502  H HB3  . ASP A 1 34  ? -19.76166 -52.86591 12.38567  1.000 35.17887 ? 34  ASP A HB3  1 
ATOM   503  N N    . VAL A 1 35  ? -19.79631 -48.53933 11.34188  1.000 25.88222 ? 35  VAL A N    1 
ATOM   504  C CA   . VAL A 1 35  ? -20.25819 -47.46385 10.47503  1.000 23.47770 ? 35  VAL A CA   1 
ATOM   505  C C    . VAL A 1 35  ? -19.17459 -46.40136 10.38606  1.000 24.68145 ? 35  VAL A C    1 
ATOM   506  O O    . VAL A 1 35  ? -18.55970 -46.04023 11.39573  1.000 24.24457 ? 35  VAL A O    1 
ATOM   507  C CB   . VAL A 1 35  ? -21.57317 -46.84287 10.99144  1.000 25.57931 ? 35  VAL A CB   1 
ATOM   508  C CG1  . VAL A 1 35  ? -22.03977 -45.74426 10.05233  1.000 26.69199 ? 35  VAL A CG1  1 
ATOM   509  C CG2  . VAL A 1 35  ? -22.64215 -47.91403 11.15906  1.000 28.66316 ? 35  VAL A CG2  1 
ATOM   510  H H    . VAL A 1 35  ? -19.45055 -48.26283 12.07917  1.000 31.08144 ? 35  VAL A H    1 
ATOM   511  H HA   . VAL A 1 35  ? -20.41052 -47.82037 9.58588   1.000 28.19602 ? 35  VAL A HA   1 
ATOM   512  H HB   . VAL A 1 35  ? -21.41714 -46.44574 11.86256  1.000 30.71795 ? 35  VAL A HB   1 
ATOM   513  H HG11 . VAL A 1 35  ? -21.54544 -44.93239 10.24576  1.000 32.05317 ? 35  VAL A HG11 1 
ATOM   514  H HG12 . VAL A 1 35  ? -21.87652 -46.02079 9.13702   1.000 32.05317 ? 35  VAL A HG12 1 
ATOM   515  H HG13 . VAL A 1 35  ? -22.98840 -45.59429 10.18838  1.000 32.05317 ? 35  VAL A HG13 1 
ATOM   516  H HG21 . VAL A 1 35  ? -22.66527 -48.46474 10.36089  1.000 34.41857 ? 35  VAL A HG21 1 
ATOM   517  H HG22 . VAL A 1 35  ? -22.42435 -48.45945 11.93106  1.000 34.41857 ? 35  VAL A HG22 1 
ATOM   518  H HG23 . VAL A 1 35  ? -23.50198 -47.48442 11.28954  1.000 34.41857 ? 35  VAL A HG23 1 
ATOM   519  N N    . VAL A 1 36  ? -18.95131 -45.89165 9.17919   1.000 22.43346 ? 36  VAL A N    1 
ATOM   520  C CA   . VAL A 1 36  ? -18.02558 -44.79112 8.94420   1.000 21.08513 ? 36  VAL A CA   1 
ATOM   521  C C    . VAL A 1 36  ? -18.84744 -43.60041 8.47334   1.000 21.94857 ? 36  VAL A C    1 
ATOM   522  O O    . VAL A 1 36  ? -19.58736 -43.69746 7.48623   1.000 22.27177 ? 36  VAL A O    1 
ATOM   523  C CB   . VAL A 1 36  ? -16.93767 -45.16632 7.92606   1.000 22.11028 ? 36  VAL A CB   1 
ATOM   524  C CG1  . VAL A 1 36  ? -16.09458 -43.94530 7.55399   1.000 18.19586 ? 36  VAL A CG1  1 
ATOM   525  C CG2  . VAL A 1 36  ? -16.04856 -46.26375 8.49151   1.000 18.54521 ? 36  VAL A CG2  1 
ATOM   526  H H    . VAL A 1 36  ? -19.33477 -46.17485 8.46340   1.000 26.94293 ? 36  VAL A H    1 
ATOM   527  H HA   . VAL A 1 36  ? -17.58282 -44.55160 9.77335   1.000 25.32493 ? 36  VAL A HA   1 
ATOM   528  H HB   . VAL A 1 36  ? -17.36611 -45.49342 7.11962   1.000 26.55511 ? 36  VAL A HB   1 
ATOM   529  H HG11 . VAL A 1 36  ? -16.68267 -43.23597 7.25083   1.000 21.85781 ? 36  VAL A HG11 1 
ATOM   530  H HG12 . VAL A 1 36  ? -15.59961 -43.65330 8.33542   1.000 21.85781 ? 36  VAL A HG12 1 
ATOM   531  H HG13 . VAL A 1 36  ? -15.47933 -44.19043 6.84528   1.000 21.85781 ? 36  VAL A HG13 1 
ATOM   532  H HG21 . VAL A 1 36  ? -15.52093 -46.64469 7.77222   1.000 22.27703 ? 36  VAL A HG21 1 
ATOM   533  H HG22 . VAL A 1 36  ? -15.46359 -45.88110 9.16404   1.000 22.27703 ? 36  VAL A HG22 1 
ATOM   534  H HG23 . VAL A 1 36  ? -16.60750 -46.94886 8.89041   1.000 22.27703 ? 36  VAL A HG23 1 
ATOM   535  N N    . TYR A 1 37  ? -18.73171 -42.48816 9.19037   1.000 23.37179 ? 37  TYR A N    1 
ATOM   536  C CA   . TYR A 1 37  ? -19.41377 -41.24850 8.84920   1.000 20.51779 ? 37  TYR A CA   1 
ATOM   537  C C    . TYR A 1 37  ? -18.43967 -40.30399 8.15859   1.000 21.45703 ? 37  TYR A C    1 
ATOM   538  O O    . TYR A 1 37  ? -17.29158 -40.16650 8.59055   1.000 25.06114 ? 37  TYR A O    1 
ATOM   539  C CB   . TYR A 1 37  ? -19.97978 -40.58479 10.10651  1.000 25.29395 ? 37  TYR A CB   1 
ATOM   540  C CG   . TYR A 1 37  ? -20.84586 -41.49597 10.94360  1.000 23.06583 ? 37  TYR A CG   1 
ATOM   541  C CD1  . TYR A 1 37  ? -20.27879 -42.42187 11.81384  1.000 25.91913 ? 37  TYR A CD1  1 
ATOM   542  C CD2  . TYR A 1 37  ? -22.22829 -41.43161 10.86719  1.000 23.71339 ? 37  TYR A CD2  1 
ATOM   543  C CE1  . TYR A 1 37  ? -21.06398 -43.25606 12.57725  1.000 22.95013 ? 37  TYR A CE1  1 
ATOM   544  C CE2  . TYR A 1 37  ? -23.02448 -42.26443 11.63257  1.000 24.14685 ? 37  TYR A CE2  1 
ATOM   545  C CZ   . TYR A 1 37  ? -22.43785 -43.17113 12.48459  1.000 25.28327 ? 37  TYR A CZ   1 
ATOM   546  O OH   . TYR A 1 37  ? -23.22443 -44.00257 13.24359  1.000 30.00335 ? 37  TYR A OH   1 
ATOM   547  H H    . TYR A 1 37  ? -18.24921 -42.42632 9.89958   1.000 28.06893 ? 37  TYR A H    1 
ATOM   548  H HA   . TYR A 1 37  ? -20.14859 -41.43092 8.24285   1.000 24.64413 ? 37  TYR A HA   1 
ATOM   549  H HB2  . TYR A 1 37  ? -19.24128 -40.28794 10.66094  1.000 30.37552 ? 37  TYR A HB2  1 
ATOM   550  H HB3  . TYR A 1 37  ? -20.52116 -39.82516 9.84048   1.000 30.37552 ? 37  TYR A HB3  1 
ATOM   551  H HD1  . TYR A 1 37  ? -19.35292 -42.47817 11.88094  1.000 31.12573 ? 37  TYR A HD1  1 
ATOM   552  H HD2  . TYR A 1 37  ? -22.62684 -40.81882 10.29225  1.000 28.47884 ? 37  TYR A HD2  1 
ATOM   553  H HE1  . TYR A 1 37  ? -20.67085 -43.87281 13.15169  1.000 27.56293 ? 37  TYR A HE1  1 
ATOM   554  H HE2  . TYR A 1 37  ? -23.95097 -42.21167 11.57149  1.000 28.99900 ? 37  TYR A HE2  1 
ATOM   555  H HH   . TYR A 1 37  ? -22.76256 -44.63306 13.55143  1.000 36.02680 ? 37  TYR A HH   1 
ATOM   556  N N    . CYS A 1 38  ? -18.89550 -39.65269 7.09030   1.000 20.73939 ? 38  CYS A N    1 
ATOM   557  C CA   . CYS A 1 38  ? -18.04678 -38.72001 6.36030   1.000 21.27528 ? 38  CYS A CA   1 
ATOM   558  C C    . CYS A 1 38  ? -18.93264 -37.72766 5.61920   1.000 21.25509 ? 38  CYS A C    1 
ATOM   559  O O    . CYS A 1 38  ? -20.11827 -37.99861 5.38602   1.000 22.59156 ? 38  CYS A O    1 
ATOM   560  C CB   . CYS A 1 38  ? -17.10934 -39.45721 5.38682   1.000 25.31533 ? 38  CYS A CB   1 
ATOM   561  S SG   . CYS A 1 38  ? -17.88876 -40.16538 3.91632   1.000 26.40882 ? 38  CYS A SG   1 
ATOM   562  H H    . CYS A 1 38  ? -19.69004 -39.73527 6.77174   1.000 24.91005 ? 38  CYS A H    1 
ATOM   563  H HA   . CYS A 1 38  ? -17.50068 -38.22130 6.98797   1.000 25.55311 ? 38  CYS A HA   1 
ATOM   564  H HB2  . CYS A 1 38  ? -16.43676 -38.82915 5.08011   1.000 30.40118 ? 38  CYS A HB2  1 
ATOM   565  H HB3  . CYS A 1 38  ? -16.68748 -40.18692 5.86688   1.000 30.40118 ? 38  CYS A HB3  1 
ATOM   566  H HG   . CYS A 1 38  ? -18.25105 -39.27441 3.19874   1.000 31.71336 ? 38  CYS A HG   1 
ATOM   567  N N    . PRO A 1 39  ? -18.39580 -36.55849 5.26431   1.000 24.20579 ? 39  PRO A N    1 
ATOM   568  C CA   . PRO A 1 39  ? -19.17248 -35.59824 4.47193   1.000 20.33361 ? 39  PRO A CA   1 
ATOM   569  C C    . PRO A 1 39  ? -19.54843 -36.18197 3.11891   1.000 22.07811 ? 39  PRO A C    1 
ATOM   570  O O    . PRO A 1 39  ? -18.76704 -36.90024 2.49212   1.000 24.05244 ? 39  PRO A O    1 
ATOM   571  C CB   . PRO A 1 39  ? -18.22260 -34.40253 4.32393   1.000 20.45341 ? 39  PRO A CB   1 
ATOM   572  C CG   . PRO A 1 39  ? -17.22078 -34.55066 5.41032   1.000 21.78612 ? 39  PRO A CG   1 
ATOM   573  C CD   . PRO A 1 39  ? -17.08609 -36.01808 5.66531   1.000 24.34019 ? 39  PRO A CD   1 
ATOM   574  H HA   . PRO A 1 39  ? -19.97169 -35.32419 4.94844   1.000 24.42311 ? 39  PRO A HA   1 
ATOM   575  H HB2  . PRO A 1 39  ? -17.79449 -34.42997 3.45395   1.000 24.56687 ? 39  PRO A HB2  1 
ATOM   576  H HB3  . PRO A 1 39  ? -18.71931 -33.57530 4.42332   1.000 24.56687 ? 39  PRO A HB3  1 
ATOM   577  H HG2  . PRO A 1 39  ? -16.37358 -34.17479 5.12418   1.000 26.16613 ? 39  PRO A HG2  1 
ATOM   578  H HG3  . PRO A 1 39  ? -17.53475 -34.09336 6.20606   1.000 26.16613 ? 39  PRO A HG3  1 
ATOM   579  H HD2  . PRO A 1 39  ? -16.37641 -36.39799 5.12410   1.000 29.23101 ? 39  PRO A HD2  1 
ATOM   580  H HD3  . PRO A 1 39  ? -16.91542 -36.19021 6.60454   1.000 29.23101 ? 39  PRO A HD3  1 
ATOM   581  N N    . ARG A 1 40  ? -20.75829 -35.85552 2.66092   1.000 20.37135 ? 40  ARG A N    1 
ATOM   582  C CA   . ARG A 1 40  ? -21.25631 -36.46211 1.43272   1.000 23.22565 ? 40  ARG A CA   1 
ATOM   583  C C    . ARG A 1 40  ? -20.55981 -35.93629 0.18229   1.000 25.41068 ? 40  ARG A C    1 
ATOM   584  O O    . ARG A 1 40  ? -20.61391 -36.59779 -0.85783  1.000 25.26463 ? 40  ARG A O    1 
ATOM   585  C CB   . ARG A 1 40  ? -22.76984 -36.25847 1.30420   1.000 22.30978 ? 40  ARG A CB   1 
ATOM   586  C CG   . ARG A 1 40  ? -23.24641 -34.82529 1.08137   1.000 25.21957 ? 40  ARG A CG   1 
ATOM   587  C CD   . ARG A 1 40  ? -24.76035 -34.81153 0.88576   1.000 28.06342 ? 40  ARG A CD   1 
ATOM   588  N NE   . ARG A 1 40  ? -25.32383 -33.46744 0.84583   1.000 26.44884 ? 40  ARG A NE   1 
ATOM   589  C CZ   . ARG A 1 40  ? -26.58815 -33.19606 0.54865   1.000 28.33771 ? 40  ARG A CZ   1 
ATOM   590  N NH1  . ARG A 1 40  ? -27.44842 -34.15479 0.24341   1.000 26.69947 ? 40  ARG A NH1  1 
ATOM   591  N NH2  . ARG A 1 40  ? -26.99769 -31.93015 0.54857   1.000 28.39541 ? 40  ARG A NH2  1 
ATOM   592  H H    . ARG A 1 40  ? -21.29579 -35.29846 3.03558   1.000 24.46840 ? 40  ARG A H    1 
ATOM   593  H HA   . ARG A 1 40  ? -21.08636 -37.41563 1.48580   1.000 27.89356 ? 40  ARG A HA   1 
ATOM   594  H HB2  . ARG A 1 40  ? -23.08142 -36.78255 0.54978   1.000 26.79452 ? 40  ARG A HB2  1 
ATOM   595  H HB3  . ARG A 1 40  ? -23.18671 -36.57319 2.12156   1.000 26.79452 ? 40  ARG A HB3  1 
ATOM   596  H HG2  . ARG A 1 40  ? -23.02625 -34.28227 1.85439   1.000 30.28626 ? 40  ARG A HG2  1 
ATOM   597  H HG3  . ARG A 1 40  ? -22.82546 -34.45905 0.28792   1.000 30.28626 ? 40  ARG A HG3  1 
ATOM   598  H HD2  . ARG A 1 40  ? -24.97275 -35.24828 0.04610   1.000 33.69888 ? 40  ARG A HD2  1 
ATOM   599  H HD3  . ARG A 1 40  ? -25.17668 -35.28697 1.62164   1.000 33.69888 ? 40  ARG A HD3  1 
ATOM   600  H HE   . ARG A 1 40  ? -24.80281 -32.80756 1.02667   1.000 31.76138 ? 40  ARG A HE   1 
ATOM   601  H HH11 . ARG A 1 40  ? -27.19216 -34.97567 0.23463   1.000 32.06214 ? 40  ARG A HH11 1 
ATOM   602  H HH12 . ARG A 1 40  ? -28.26357 -33.95674 0.05388   1.000 32.06214 ? 40  ARG A HH12 1 
ATOM   603  H HH21 . ARG A 1 40  ? -26.44515 -31.29944 0.73963   1.000 34.09727 ? 40  ARG A HH21 1 
ATOM   604  H HH22 . ARG A 1 40  ? -27.81494 -31.74262 0.35746   1.000 34.09727 ? 40  ARG A HH22 1 
ATOM   605  N N    . HIS A 1 41  ? -19.89400 -34.78519 0.24835   1.000 24.06974 ? 41  HIS A N    1 
ATOM   606  C CA   . HIS A 1 41  ? -19.22499 -34.25084 -0.93210  1.000 25.41674 ? 41  HIS A CA   1 
ATOM   607  C C    . HIS A 1 41  ? -17.94000 -34.99701 -1.26225  1.000 23.78247 ? 41  HIS A C    1 
ATOM   608  O O    . HIS A 1 41  ? -17.22482 -34.58699 -2.18082  1.000 21.88707 ? 41  HIS A O    1 
ATOM   609  C CB   . HIS A 1 41  ? -18.95950 -32.74376 -0.76714  1.000 21.32919 ? 41  HIS A CB   1 
ATOM   610  C CG   . HIS A 1 41  ? -17.87070 -32.39510 0.20496   1.000 22.05660 ? 41  HIS A CG   1 
ATOM   611  N ND1  . HIS A 1 41  ? -18.12621 -31.90021 1.46671   1.000 22.52014 ? 41  HIS A ND1  1 
ATOM   612  C CD2  . HIS A 1 41  ? -16.52245 -32.41638 0.07793   1.000 25.67690 ? 41  HIS A CD2  1 
ATOM   613  C CE1  . HIS A 1 41  ? -16.98246 -31.65933 2.08397   1.000 24.38349 ? 41  HIS A CE1  1 
ATOM   614  N NE2  . HIS A 1 41  ? -15.99407 -31.96385 1.26272   1.000 20.91484 ? 41  HIS A NE2  1 
ATOM   615  H H    . HIS A 1 41  ? -19.81736 -34.30312 0.95640   1.000 28.90646 ? 41  HIS A H    1 
ATOM   616  H HA   . HIS A 1 41  ? -19.81706 -34.34449 -1.69472  1.000 30.52287 ? 41  HIS A HA   1 
ATOM   617  H HB2  . HIS A 1 41  ? -18.70641 -32.38016 -1.63006  1.000 25.61780 ? 41  HIS A HB2  1 
ATOM   618  H HB3  . HIS A 1 41  ? -19.77461 -32.32061 -0.45498  1.000 25.61780 ? 41  HIS A HB3  1 
ATOM   619  H HD2  . HIS A 1 41  ? -16.04339 -32.68700 -0.67185  1.000 30.83505 ? 41  HIS A HD2  1 
ATOM   620  H HE1  . HIS A 1 41  ? -16.88959 -31.33129 2.94922   1.000 29.28297 ? 41  HIS A HE1  1 
ATOM   621  H HE2  . HIS A 1 41  ? -15.15586 -31.89076 1.44063   1.000 25.12059 ? 41  HIS A HE2  1 
ATOM   622  N N    . VAL A 1 42  ? -17.64630 -36.09631 -0.56158  1.000 25.34630 ? 42  VAL A N    1 
ATOM   623  C CA   . VAL A 1 42  ? -16.56474 -36.96902 -0.99276  1.000 24.74483 ? 42  VAL A CA   1 
ATOM   624  C C    . VAL A 1 42  ? -16.87457 -37.56527 -2.35740  1.000 29.40004 ? 42  VAL A C    1 
ATOM   625  O O    . VAL A 1 42  ? -15.95882 -37.98970 -3.06774  1.000 27.29973 ? 42  VAL A O    1 
ATOM   626  C CB   . VAL A 1 42  ? -16.30215 -38.08096 0.04831   1.000 24.30289 ? 42  VAL A CB   1 
ATOM   627  C CG1  . VAL A 1 42  ? -17.37886 -39.14850 -0.01386  1.000 25.69399 ? 42  VAL A CG1  1 
ATOM   628  C CG2  . VAL A 1 42  ? -14.92246 -38.68589 -0.16228  1.000 27.91399 ? 42  VAL A CG2  1 
ATOM   629  H H    . VAL A 1 42  ? -18.05312 -36.34990 0.15241   1.000 30.43833 ? 42  VAL A H    1 
ATOM   630  H HA   . VAL A 1 42  ? -15.75236 -36.44311 -1.05881  1.000 29.71658 ? 42  VAL A HA   1 
ATOM   631  H HB   . VAL A 1 42  ? -16.32953 -37.69084 0.93598   1.000 29.18625 ? 42  VAL A HB   1 
ATOM   632  H HG11 . VAL A 1 42  ? -17.23875 -39.78078 0.70829   1.000 30.85556 ? 42  VAL A HG11 1 
ATOM   633  H HG12 . VAL A 1 42  ? -18.24741 -38.72684 0.07953   1.000 30.85556 ? 42  VAL A HG12 1 
ATOM   634  H HG13 . VAL A 1 42  ? -17.32263 -39.60437 -0.86821  1.000 30.85556 ? 42  VAL A HG13 1 
ATOM   635  H HG21 . VAL A 1 42  ? -14.88690 -39.09256 -1.04220  1.000 33.51956 ? 42  VAL A HG21 1 
ATOM   636  H HG22 . VAL A 1 42  ? -14.25630 -37.98402 -0.09509  1.000 33.51956 ? 42  VAL A HG22 1 
ATOM   637  H HG23 . VAL A 1 42  ? -14.76488 -39.35784 0.51929   1.000 33.51956 ? 42  VAL A HG23 1 
ATOM   638  N N    . ILE A 1 43  ? -18.15609 -37.61705 -2.74157  1.000 28.27032 ? 43  ILE A N    1 
ATOM   639  C CA   . ILE A 1 43  ? -18.54410 -38.17159 -4.03761  1.000 28.04637 ? 43  ILE A CA   1 
ATOM   640  C C    . ILE A 1 43  ? -18.45062 -37.15177 -5.16130  1.000 31.01957 ? 43  ILE A C    1 
ATOM   641  O O    . ILE A 1 43  ? -18.74561 -37.48740 -6.31655  1.000 33.14677 ? 43  ILE A O    1 
ATOM   642  C CB   . ILE A 1 43  ? -19.97801 -38.74262 -3.98761  1.000 27.82404 ? 43  ILE A CB   1 
ATOM   643  C CG1  . ILE A 1 43  ? -21.00893 -37.61301 -3.87327  1.000 27.33346 ? 43  ILE A CG1  1 
ATOM   644  C CG2  . ILE A 1 43  ? -20.11354 -39.70926 -2.82234  1.000 27.86574 ? 43  ILE A CG2  1 
ATOM   645  C CD1  . ILE A 1 43  ? -22.44886 -38.09450 -3.77265  1.000 29.45727 ? 43  ILE A CD1  1 
ATOM   646  H H    . ILE A 1 43  ? -18.81703 -37.33694 -2.26797  1.000 33.94716 ? 43  ILE A H    1 
ATOM   647  H HA   . ILE A 1 43  ? -17.93401 -38.89686 -4.24416  1.000 33.67842 ? 43  ILE A HA   1 
ATOM   648  H HB   . ILE A 1 43  ? -20.14628 -39.22124 -4.81436  1.000 33.41162 ? 43  ILE A HB   1 
ATOM   649  H HG12 . ILE A 1 43  ? -20.81506 -37.09501 -3.07641  1.000 32.82293 ? 43  ILE A HG12 1 
ATOM   650  H HG13 . ILE A 1 43  ? -20.94091 -37.04958 -4.65992  1.000 32.82293 ? 43  ILE A HG13 1 
ATOM   651  H HG21 . ILE A 1 43  ? -20.86023 -40.30491 -2.99135  1.000 33.46167 ? 43  ILE A HG21 1 
ATOM   652  H HG22 . ILE A 1 43  ? -19.29392 -40.22144 -2.73992  1.000 33.46167 ? 43  ILE A HG22 1 
ATOM   653  H HG23 . ILE A 1 43  ? -20.27096 -39.20391 -2.00948  1.000 33.46167 ? 43  ILE A HG23 1 
ATOM   654  H HD11 . ILE A 1 43  ? -23.03093 -37.32738 -3.65590  1.000 35.37150 ? 43  ILE A HD11 1 
ATOM   655  H HD12 . ILE A 1 43  ? -22.68201 -38.56561 -4.58787  1.000 35.37150 ? 43  ILE A HD12 1 
ATOM   656  H HD13 . ILE A 1 43  ? -22.53016 -38.69029 -3.01152  1.000 35.37150 ? 43  ILE A HD13 1 
ATOM   657  N N    . CYS A 1 44  ? -18.05038 -35.91923 -4.86622  1.000 25.85826 ? 44  CYS A N    1 
ATOM   658  C CA   . CYS A 1 44  ? -17.96921 -34.87306 -5.87306  1.000 28.80994 ? 44  CYS A CA   1 
ATOM   659  C C    . CYS A 1 44  ? -16.56858 -34.80994 -6.46285  1.000 32.61834 ? 44  CYS A C    1 
ATOM   660  O O    . CYS A 1 44  ? -15.57458 -35.00170 -5.75701  1.000 29.82287 ? 44  CYS A O    1 
ATOM   661  C CB   . CYS A 1 44  ? -18.31802 -33.50971 -5.27273  1.000 33.97262 ? 44  CYS A CB   1 
ATOM   662  S SG   . CYS A 1 44  ? -20.02876 -33.31592 -4.74201  1.000 30.79431 ? 44  CYS A SG   1 
ATOM   663  H H    . CYS A 1 44  ? -17.81787 -35.66288 -4.07893  1.000 31.05269 ? 44  CYS A H    1 
ATOM   664  H HA   . CYS A 1 44  ? -18.60072 -35.07339 -6.58154  1.000 34.59471 ? 44  CYS A HA   1 
ATOM   665  H HB2  . CYS A 1 44  ? -17.75573 -33.36511 -4.49567  1.000 40.78992 ? 44  CYS A HB2  1 
ATOM   666  H HB3  . CYS A 1 44  ? -18.14306 -32.82808 -5.94032  1.000 40.78992 ? 44  CYS A HB3  1 
ATOM   667  H HG   . CYS A 1 44  ? -20.27201 -34.13601 -3.90041  1.000 36.97596 ? 44  CYS A HG   1 
ATOM   668  N N    . THR A 1 45  ? -16.49828 -34.55139 -7.76370  1.000 35.56436 ? 45  THR A N    1 
ATOM   669  C CA   . THR A 1 45  ? -15.27335 -34.03548 -8.34686  1.000 41.10508 ? 45  THR A CA   1 
ATOM   670  C C    . THR A 1 45  ? -15.16647 -32.54648 -8.03295  1.000 43.85910 ? 45  THR A C    1 
ATOM   671  O O    . THR A 1 45  ? -16.16184 -31.87932 -7.73797  1.000 38.89185 ? 45  THR A O    1 
ATOM   672  C CB   . THR A 1 45  ? -15.24857 -34.26053 -9.85913  1.000 42.97043 ? 45  THR A CB   1 
ATOM   673  O OG1  . THR A 1 45  ? -16.40332 -33.65505 -10.45384 1.000 43.91690 ? 45  THR A OG1  1 
ATOM   674  C CG2  . THR A 1 45  ? -15.22588 -35.75076 -10.18219 1.000 38.18952 ? 45  THR A CG2  1 
ATOM   675  H H    . THR A 1 45  ? -17.14174 -34.66609 -8.32263  1.000 42.70001 ? 45  THR A H    1 
ATOM   676  H HA   . THR A 1 45  ? -14.50511 -34.49844 -7.97756  1.000 49.34888 ? 45  THR A HA   1 
ATOM   677  H HB   . THR A 1 45  ? -14.44811 -33.85995 -10.23291 1.000 51.58730 ? 45  THR A HB   1 
ATOM   678  H HG1  . THR A 1 45  ? -16.35517 -32.81899 -10.38843 1.000 52.72306 ? 45  THR A HG1  1 
ATOM   679  H HG21 . THR A 1 45  ? -14.43228 -36.16027 -9.80349  1.000 45.85020 ? 45  THR A HG21 1 
ATOM   680  H HG22 . THR A 1 45  ? -16.01088 -36.18276 -9.81064  1.000 45.85020 ? 45  THR A HG22 1 
ATOM   681  H HG23 . THR A 1 45  ? -15.21966 -35.88182 -11.14327 1.000 45.85020 ? 45  THR A HG23 1 
ATOM   682  N N    . SER A 1 46  ? -13.94151 -32.02072 -8.09737  1.000 48.51494 ? 46  SER A N    1 
ATOM   683  C CA   . SER A 1 46  ? -13.74423 -30.60952 -7.78357  1.000 53.43059 ? 46  SER A CA   1 
ATOM   684  C C    . SER A 1 46  ? -14.63914 -29.70492 -8.62376  1.000 49.74044 ? 46  SER A C    1 
ATOM   685  O O    . SER A 1 46  ? -14.87150 -28.55323 -8.24120  1.000 46.62157 ? 46  SER A O    1 
ATOM   686  C CB   . SER A 1 46  ? -12.27584 -30.22685 -7.97692  1.000 51.75034 ? 46  SER A CB   1 
ATOM   687  O OG   . SER A 1 46  ? -11.84054 -30.53093 -9.28765  1.000 59.39781 ? 46  SER A OG   1 
ATOM   688  H H    . SER A 1 46  ? -13.22843 -32.44964 -8.31449  1.000 58.24070 ? 46  SER A H    1 
ATOM   689  H HA   . SER A 1 46  ? -13.96519 -30.46266 -6.85056  1.000 64.13948 ? 46  SER A HA   1 
ATOM   690  H HB2  . SER A 1 46  ? -12.17595 -29.27406 -7.82491  1.000 62.12318 ? 46  SER A HB2  1 
ATOM   691  H HB3  . SER A 1 46  ? -11.73493 -30.72254 -7.34241  1.000 62.12318 ? 46  SER A HB3  1 
ATOM   692  H HG   . SER A 1 46  ? -11.88583 -31.35911 -9.42054  1.000 71.30015 ? 46  SER A HG   1 
ATOM   693  N N    . GLU A 1 47  ? -15.14644 -30.19847 -9.75719  1.000 45.20844 ? 47  GLU A N    1 
ATOM   694  C CA   . GLU A 1 47  ? -16.08279 -29.42743 -10.56865 1.000 48.48223 ? 47  GLU A CA   1 
ATOM   695  C C    . GLU A 1 47  ? -17.52217 -29.56797 -10.08359 1.000 45.42968 ? 47  GLU A C    1 
ATOM   696  O O    . GLU A 1 47  ? -18.29777 -28.61003 -10.17640 1.000 44.63014 ? 47  GLU A O    1 
ATOM   697  C CB   . GLU A 1 47  ? -15.97414 -29.86262 -12.03187 1.000 54.25647 ? 47  GLU A CB   1 
ATOM   698  C CG   . GLU A 1 47  ? -17.26335 -29.74593 -12.83239 1.000 62.06951 ? 47  GLU A CG   1 
ATOM   699  C CD   . GLU A 1 47  ? -17.03519 -29.88892 -14.32529 1.000 83.90287 ? 47  GLU A CD   1 
ATOM   700  O OE1  . GLU A 1 47  ? -15.87347 -29.76375 -14.76471 1.000 83.77214 ? 47  GLU A OE1  1 
ATOM   701  O OE2  . GLU A 1 47  ? -18.01806 -30.12853 -15.05897 1.000 87.81014 ? 47  GLU A OE2  1 
ATOM   702  H H    . GLU A 1 47  ? -14.96325 -30.97606 -10.07560 1.000 54.27290 ? 47  GLU A H    1 
ATOM   703  H HA   . GLU A 1 47  ? -15.84700 -28.48823 -10.51204 1.000 58.20145 ? 47  GLU A HA   1 
ATOM   704  H HB2  . GLU A 1 47  ? -15.30877 -29.30831 -12.46882 1.000 65.13054 ? 47  GLU A HB2  1 
ATOM   705  H HB3  . GLU A 1 47  ? -15.69921 -30.79251 -12.05638 1.000 65.13054 ? 47  GLU A HB3  1 
ATOM   706  H HG2  . GLU A 1 47  ? -17.87443 -30.44550 -12.55297 1.000 74.50619 ? 47  GLU A HG2  1 
ATOM   707  H HG3  . GLU A 1 47  ? -17.65934 -28.87536 -12.67050 1.000 74.50619 ? 47  GLU A HG3  1 
ATOM   708  N N    . ASP A 1 48  ? -17.89806 -30.74070 -9.56856  1.000 41.03696 ? 48  ASP A N    1 
ATOM   709  C CA   . ASP A 1 48  ? -19.26638 -30.93929 -9.09978  1.000 40.14984 ? 48  ASP A CA   1 
ATOM   710  C C    . ASP A 1 48  ? -19.60389 -30.02792 -7.92465  1.000 36.40919 ? 48  ASP A C    1 
ATOM   711  O O    . ASP A 1 48  ? -20.77759 -29.70461 -7.70569  1.000 34.89298 ? 48  ASP A O    1 
ATOM   712  C CB   . ASP A 1 48  ? -19.47504 -32.39780 -8.68497  1.000 40.22547 ? 48  ASP A CB   1 
ATOM   713  C CG   . ASP A 1 48  ? -19.43074 -33.36154 -9.85548  1.000 43.99819 ? 48  ASP A CG   1 
ATOM   714  O OD1  . ASP A 1 48  ? -19.71054 -32.94372 -10.99710 1.000 48.04636 ? 48  ASP A OD1  1 
ATOM   715  O OD2  . ASP A 1 48  ? -19.11890 -34.54883 -9.62100  1.000 40.22498 ? 48  ASP A OD2  1 
ATOM   716  H H    . ASP A 1 48  ? -17.38677 -31.42666 -9.48113  1.000 49.26713 ? 48  ASP A H    1 
ATOM   717  H HA   . ASP A 1 48  ? -19.86856 -30.73295 -9.83170  1.000 48.20258 ? 48  ASP A HA   1 
ATOM   718  H HB2  . ASP A 1 48  ? -18.77528 -32.65135 -8.06292  1.000 48.29335 ? 48  ASP A HB2  1 
ATOM   719  H HB3  . ASP A 1 48  ? -20.34310 -32.48329 -8.26064  1.000 48.29335 ? 48  ASP A HB3  1 
ATOM   720  N N    . MET A 1 49  ? -18.59444 -29.60170 -7.16239  1.000 38.10025 ? 49  MET A N    1 
ATOM   721  C CA   . MET A 1 49  ? -18.84068 -28.95057 -5.87977  1.000 36.87610 ? 49  MET A CA   1 
ATOM   722  C C    . MET A 1 49  ? -19.49574 -27.58033 -6.01275  1.000 33.01252 ? 49  MET A C    1 
ATOM   723  O O    . MET A 1 49  ? -20.08158 -27.09627 -5.03810  1.000 31.64411 ? 49  MET A O    1 
ATOM   724  C CB   . MET A 1 49  ? -17.52528 -28.83112 -5.11106  1.000 33.00754 ? 49  MET A CB   1 
ATOM   725  C CG   . MET A 1 49  ? -17.04312 -30.16193 -4.55075  1.000 37.16420 ? 49  MET A CG   1 
ATOM   726  S SD   . MET A 1 49  ? -15.31504 -30.14267 -4.05595  1.000 51.84142 ? 49  MET A SD   1 
ATOM   727  C CE   . MET A 1 49  ? -15.07817 -31.87030 -3.65842  1.000 36.18348 ? 49  MET A CE   1 
ATOM   728  H H    . MET A 1 49  ? -17.76233 -29.67803 -7.36578  1.000 45.74308 ? 49  MET A H    1 
ATOM   729  H HA   . MET A 1 49  ? -19.44489 -29.51076 -5.36790  1.000 44.27409 ? 49  MET A HA   1 
ATOM   730  H HB2  . MET A 1 49  ? -16.84077 -28.49195 -5.70880  1.000 39.63182 ? 49  MET A HB2  1 
ATOM   731  H HB3  . MET A 1 49  ? -17.64909 -28.22022 -4.36784  1.000 39.63182 ? 49  MET A HB3  1 
ATOM   732  H HG2  . MET A 1 49  ? -17.57367 -30.38424 -3.76973  1.000 44.61982 ? 49  MET A HG2  1 
ATOM   733  H HG3  . MET A 1 49  ? -17.15033 -30.84579 -5.23027  1.000 44.61982 ? 49  MET A HG3  1 
ATOM   734  H HE1  . MET A 1 49  ? -15.64409 -32.10154 -2.90532  1.000 43.44295 ? 49  MET A HE1  1 
ATOM   735  H HE2  . MET A 1 49  ? -15.31795 -32.40757 -4.42962  1.000 43.44295 ? 49  MET A HE2  1 
ATOM   736  H HE3  . MET A 1 49  ? -14.14698 -32.01695 -3.42974  1.000 43.44295 ? 49  MET A HE3  1 
ATOM   737  N N    . PHE A 1 50  ? -19.41873 -26.94345 -7.18127  1.000 33.72340 ? 50  PHE A N    1 
ATOM   738  C CA   . PHE A 1 50  ? -20.02772 -25.62952 -7.35076  1.000 33.30926 ? 50  PHE A CA   1 
ATOM   739  C C    . PHE A 1 50  ? -21.54103 -25.70786 -7.50404  1.000 36.73702 ? 50  PHE A C    1 
ATOM   740  O O    . PHE A 1 50  ? -22.22867 -24.71420 -7.24813  1.000 34.42644 ? 50  PHE A O    1 
ATOM   741  C CB   . PHE A 1 50  ? -19.38951 -24.91930 -8.54875  1.000 35.74505 ? 50  PHE A CB   1 
ATOM   742  C CG   . PHE A 1 50  ? -17.96182 -24.50418 -8.30669  1.000 36.56903 ? 50  PHE A CG   1 
ATOM   743  C CD1  . PHE A 1 50  ? -17.67718 -23.38472 -7.54115  1.000 37.38445 ? 50  PHE A CD1  1 
ATOM   744  C CD2  . PHE A 1 50  ? -16.90663 -25.23811 -8.82680  1.000 39.54704 ? 50  PHE A CD2  1 
ATOM   745  C CE1  . PHE A 1 50  ? -16.36891 -22.99875 -7.30452  1.000 36.50507 ? 50  PHE A CE1  1 
ATOM   746  C CE2  . PHE A 1 50  ? -15.59220 -24.85438 -8.59312  1.000 38.75419 ? 50  PHE A CE2  1 
ATOM   747  C CZ   . PHE A 1 50  ? -15.32607 -23.73400 -7.82945  1.000 37.69427 ? 50  PHE A CZ   1 
ATOM   748  H H    . PHE A 1 50  ? -19.02386 -27.24859 -7.88167  1.000 40.49086 ? 50  PHE A H    1 
ATOM   749  H HA   . PHE A 1 50  ? -19.85240 -25.08401 -6.56809  1.000 39.99389 ? 50  PHE A HA   1 
ATOM   750  N N    . ASN A 1 51  ? -22.07444 -26.86069 -7.89838  1.000 35.66505 ? 51  ASN A N    1 
ATOM   751  C CA   . ASN A 1 51  ? -23.51576 -27.07033 -7.89493  1.000 35.73146 ? 51  ASN A CA   1 
ATOM   752  C C    . ASN A 1 51  ? -23.81664 -28.56237 -7.96557  1.000 35.56993 ? 51  ASN A C    1 
ATOM   753  O O    . ASN A 1 51  ? -24.15880 -29.07853 -9.03785  1.000 36.30249 ? 51  ASN A O    1 
ATOM   754  C CB   . ASN A 1 51  ? -24.18740 -26.34298 -9.05817  1.000 40.16247 ? 51  ASN A CB   1 
ATOM   755  C CG   . ASN A 1 51  ? -25.69807 -26.42717 -8.98949  1.000 44.41460 ? 51  ASN A CG   1 
ATOM   756  O OD1  . ASN A 1 51  ? -26.26640 -26.62828 -7.91625  1.000 42.44626 ? 51  ASN A OD1  1 
ATOM   757  N ND2  . ASN A 1 51  ? -26.35712 -26.28070 -10.13189 1.000 61.71581 ? 51  ASN A ND2  1 
ATOM   758  H H    . ASN A 1 51  ? -21.62046 -27.53759 -8.17282  1.000 42.82084 ? 51  ASN A H    1 
ATOM   759  H HA   . ASN A 1 51  ? -23.88276 -26.71300 -7.07120  1.000 42.90053 ? 51  ASN A HA   1 
ATOM   760  H HB2  . ASN A 1 51  ? -23.93544 -25.40654 -9.03609  1.000 48.21775 ? 51  ASN A HB2  1 
ATOM   761  H HB3  . ASN A 1 51  ? -23.89985 -26.74431 -9.89312  1.000 48.21775 ? 51  ASN A HB3  1 
ATOM   762  H HD21 . ASN A 1 51  ? -27.21612 -26.32105 -10.14098 1.000 74.08175 ? 51  ASN A HD21 1 
ATOM   763  H HD22 . ASN A 1 51  ? -25.92524 -26.14543 -10.86318 1.000 74.08175 ? 51  ASN A HD22 1 
ATOM   764  N N    . PRO A 1 52  ? -23.70394 -29.28739 -6.85672  1.000 30.94025 ? 52  PRO A N    1 
ATOM   765  C CA   . PRO A 1 52  ? -23.91838 -30.73484 -6.90172  1.000 34.64843 ? 52  PRO A CA   1 
ATOM   766  C C    . PRO A 1 52  ? -25.38259 -31.10818 -6.75613  1.000 32.80482 ? 52  PRO A C    1 
ATOM   767  O O    . PRO A 1 52  ? -26.15472 -30.45668 -6.05057  1.000 34.14514 ? 52  PRO A O    1 
ATOM   768  C CB   . PRO A 1 52  ? -23.10739 -31.24074 -5.70158  1.000 35.91415 ? 52  PRO A CB   1 
ATOM   769  C CG   . PRO A 1 52  ? -23.17392 -30.10325 -4.71352  1.000 33.09161 ? 52  PRO A CG   1 
ATOM   770  C CD   . PRO A 1 52  ? -23.30524 -28.82612 -5.51251  1.000 31.40100 ? 52  PRO A CD   1 
ATOM   771  H HA   . PRO A 1 52  ? -23.56380 -31.11357 -7.72132  1.000 41.60089 ? 52  PRO A HA   1 
ATOM   772  H HB2  . PRO A 1 52  ? -23.51192 -32.04451 -5.33936  1.000 43.11975 ? 52  PRO A HB2  1 
ATOM   773  H HB3  . PRO A 1 52  ? -22.19236 -31.42106 -5.96825  1.000 43.11975 ? 52  PRO A HB3  1 
ATOM   774  H HG2  . PRO A 1 52  ? -23.94448 -30.22269 -4.13658  1.000 39.73271 ? 52  PRO A HG2  1 
ATOM   775  H HG3  . PRO A 1 52  ? -22.36163 -30.08932 -4.18353  1.000 39.73271 ? 52  PRO A HG3  1 
ATOM   776  H HD2  . PRO A 1 52  ? -23.98732 -28.25162 -5.13092  1.000 37.70398 ? 52  PRO A HD2  1 
ATOM   777  H HD3  . PRO A 1 52  ? -22.45766 -28.35581 -5.54887  1.000 37.70398 ? 52  PRO A HD3  1 
ATOM   778  N N    . ASN A 1 53  ? -25.75811 -32.17737 -7.45026  1.000 31.37224 ? 53  ASN A N    1 
ATOM   779  C CA   . ASN A 1 53  ? -27.01696 -32.87652 -7.20683  1.000 32.81263 ? 53  ASN A CA   1 
ATOM   780  C C    . ASN A 1 53  ? -26.62779 -34.19917 -6.54905  1.000 33.40117 ? 53  ASN A C    1 
ATOM   781  O O    . ASN A 1 53  ? -26.36642 -35.19439 -7.22578  1.000 27.21019 ? 53  ASN A O    1 
ATOM   782  C CB   . ASN A 1 53  ? -27.81999 -33.08517 -8.48892  1.000 35.35021 ? 53  ASN A CB   1 
ATOM   783  C CG   . ASN A 1 53  ? -29.18146 -33.69720 -8.22182  1.000 33.59879 ? 53  ASN A CG   1 
ATOM   784  O OD1  . ASN A 1 53  ? -29.30366 -34.64706 -7.44981  1.000 37.54837 ? 53  ASN A OD1  1 
ATOM   785  N ND2  . ASN A 1 53  ? -30.21493 -33.14385 -8.84395  1.000 38.82324 ? 53  ASN A ND2  1 
ATOM   786  H H    . ASN A 1 53  ? -25.28958 -32.52480 -8.08222  1.000 37.66946 ? 53  ASN A H    1 
ATOM   787  H HA   . ASN A 1 53  ? -27.57871 -32.35781 -6.60994  1.000 39.39793 ? 53  ASN A HA   1 
ATOM   788  H HB2  . ASN A 1 53  ? -27.95415 -32.22815 -8.92299  1.000 42.44302 ? 53  ASN A HB2  1 
ATOM   789  H HB3  . ASN A 1 53  ? -27.33085 -33.68185 -9.07681  1.000 42.44302 ? 53  ASN A HB3  1 
ATOM   790  H HD21 . ASN A 1 53  ? -31.00698 -33.45658 -8.72367  1.000 46.61067 ? 53  ASN A HD21 1 
ATOM   791  H HD22 . ASN A 1 53  ? -30.09259 -32.47254 -9.36739  1.000 46.61067 ? 53  ASN A HD22 1 
ATOM   792  N N    . TYR A 1 54  ? -26.58444 -34.19825 -5.21464  1.000 30.33680 ? 54  TYR A N    1 
ATOM   793  C CA   . TYR A 1 54  ? -26.01262 -35.33167 -4.49429  1.000 31.90709 ? 54  TYR A CA   1 
ATOM   794  C C    . TYR A 1 54  ? -26.77289 -36.62555 -4.75783  1.000 32.79494 ? 54  TYR A C    1 
ATOM   795  O O    . TYR A 1 54  ? -26.17538 -37.70699 -4.73311  1.000 30.77158 ? 54  TYR A O    1 
ATOM   796  C CB   . TYR A 1 54  ? -25.97044 -35.02983 -2.99652  1.000 32.12234 ? 54  TYR A CB   1 
ATOM   797  C CG   . TYR A 1 54  ? -24.88694 -34.03940 -2.62769  1.000 28.56304 ? 54  TYR A CG   1 
ATOM   798  C CD1  . TYR A 1 54  ? -23.54521 -34.39523 -2.68707  1.000 27.33984 ? 54  TYR A CD1  1 
ATOM   799  C CD2  . TYR A 1 54  ? -25.20333 -32.74703 -2.23428  1.000 26.45600 ? 54  TYR A CD2  1 
ATOM   800  C CE1  . TYR A 1 54  ? -22.55166 -33.49315 -2.35718  1.000 28.15154 ? 54  TYR A CE1  1 
ATOM   801  C CE2  . TYR A 1 54  ? -24.21591 -31.83814 -1.89726  1.000 22.39651 ? 54  TYR A CE2  1 
ATOM   802  C CZ   . TYR A 1 54  ? -22.89178 -32.21573 -1.96281  1.000 24.20103 ? 54  TYR A CZ   1 
ATOM   803  O OH   . TYR A 1 54  ? -21.90247 -31.31674 -1.63459  1.000 23.09162 ? 54  TYR A OH   1 
ATOM   804  H H    . TYR A 1 54  ? -26.87497 -33.56349 -4.71237  1.000 36.42694 ? 54  TYR A H    1 
ATOM   805  H HA   . TYR A 1 54  ? -25.10235 -35.46371 -4.80231  1.000 38.31128 ? 54  TYR A HA   1 
ATOM   806  H HB2  . TYR A 1 54  ? -26.82357 -34.65590 -2.72590  1.000 38.56958 ? 54  TYR A HB2  1 
ATOM   807  H HB3  . TYR A 1 54  ? -25.80104 -35.85367 -2.51331  1.000 38.56958 ? 54  TYR A HB3  1 
ATOM   808  H HD1  . TYR A 1 54  ? -23.31175 -35.25516 -2.95336  1.000 32.83059 ? 54  TYR A HD1  1 
ATOM   809  H HD2  . TYR A 1 54  ? -26.09539 -32.48688 -2.19641  1.000 31.76998 ? 54  TYR A HD2  1 
ATOM   810  H HE1  . TYR A 1 54  ? -21.65779 -33.74611 -2.40085  1.000 33.80463 ? 54  TYR A HE1  1 
ATOM   811  H HE2  . TYR A 1 54  ? -24.44422 -30.97770 -1.62814  1.000 26.89859 ? 54  TYR A HE2  1 
ATOM   812  H HH   . TYR A 1 54  ? -22.18836 -30.53141 -1.71899  1.000 27.73272 ? 54  TYR A HH   1 
ATOM   813  N N    . GLU A 1 55  ? -28.07945 -36.54420 -5.01228  1.000 31.55246 ? 55  GLU A N    1 
ATOM   814  C CA   . GLU A 1 55  ? -28.84497 -37.75050 -5.31192  1.000 36.38976 ? 55  GLU A CA   1 
ATOM   815  C C    . GLU A 1 55  ? -28.38331 -38.37554 -6.62154  1.000 33.68064 ? 55  GLU A C    1 
ATOM   816  O O    . GLU A 1 55  ? -28.09609 -39.57656 -6.68452  1.000 34.38379 ? 55  GLU A O    1 
ATOM   817  C CB   . GLU A 1 55  ? -30.33779 -37.42678 -5.37488  1.000 37.86880 ? 55  GLU A CB   1 
ATOM   818  C CG   . GLU A 1 55  ? -30.95912 -37.05174 -4.03310  1.000 49.45244 ? 55  GLU A CG   1 
ATOM   819  C CD   . GLU A 1 55  ? -30.51537 -35.68787 -3.52154  1.000 54.41349 ? 55  GLU A CD   1 
ATOM   820  O OE1  . GLU A 1 55  ? -30.24454 -34.78987 -4.34973  1.000 44.94790 ? 55  GLU A OE1  1 
ATOM   821  O OE2  . GLU A 1 55  ? -30.43054 -35.51640 -2.28568  1.000 58.12706 ? 55  GLU A OE2  1 
ATOM   822  H H    . GLU A 1 55  ? -28.53708 -35.81609 -5.01740  1.000 37.88572 ? 55  GLU A H    1 
ATOM   823  H HA   . GLU A 1 55  ? -28.70553 -38.39258 -4.59835  1.000 43.69049 ? 55  GLU A HA   1 
ATOM   824  H HB2  . GLU A 1 55  ? -30.46655 -36.67755 -5.97735  1.000 45.46533 ? 55  GLU A HB2  1 
ATOM   825  H HB3  . GLU A 1 55  ? -30.80930 -38.20590 -5.70887  1.000 45.46533 ? 55  GLU A HB3  1 
ATOM   826  H HG2  . GLU A 1 55  ? -31.92426 -37.03383 -4.12843  1.000 59.36571 ? 55  GLU A HG2  1 
ATOM   827  H HG3  . GLU A 1 55  ? -30.70322 -37.71455 -3.37273  1.000 59.36571 ? 55  GLU A HG3  1 
ATOM   828  N N    . ASP A 1 56  ? -28.30369 -37.56885 -7.68109  1.000 32.81118 ? 56  ASP A N    1 
ATOM   829  C CA   . ASP A 1 56  ? -27.86812 -38.08488 -8.97448  1.000 35.98071 ? 56  ASP A CA   1 
ATOM   830  C C    . ASP A 1 56  ? -26.42041 -38.55914 -8.92105  1.000 37.75394 ? 56  ASP A C    1 
ATOM   831  O O    . ASP A 1 56  ? -26.06108 -39.55273 -9.56480  1.000 36.67789 ? 56  ASP A O    1 
ATOM   832  C CB   . ASP A 1 56  ? -28.03957 -37.01084 -10.05072 1.000 38.14027 ? 56  ASP A CB   1 
ATOM   833  C CG   . ASP A 1 56  ? -29.49492 -36.68522 -10.32779 1.000 38.01787 ? 56  ASP A CG   1 
ATOM   834  O OD1  . ASP A 1 56  ? -30.38345 -37.24351 -9.64182  1.000 38.67015 ? 56  ASP A OD1  1 
ATOM   835  O OD2  . ASP A 1 56  ? -29.75753 -35.86667 -11.23773 1.000 41.34171 ? 56  ASP A OD2  1 
ATOM   836  H H    . ASP A 1 56  ? -28.49391 -36.73016 -7.67654  1.000 39.39620 ? 56  ASP A H    1 
ATOM   837  H HA   . ASP A 1 56  ? -28.42462 -38.84306 -9.21192  1.000 43.19963 ? 56  ASP A HA   1 
ATOM   838  H HB2  . ASP A 1 56  ? -27.60057 -36.19695 -9.75788  1.000 45.79110 ? 56  ASP A HB2  1 
ATOM   839  H HB3  . ASP A 1 56  ? -27.63982 -37.32458 -10.87696 1.000 45.79110 ? 56  ASP A HB3  1 
ATOM   840  N N    . LEU A 1 57  ? -25.57149 -37.85839 -8.16235  1.000 31.18332 ? 57  LEU A N    1 
ATOM   841  C CA   . LEU A 1 57  ? -24.16956 -38.25634 -8.06214  1.000 31.48868 ? 57  LEU A CA   1 
ATOM   842  C C    . LEU A 1 57  ? -24.02055 -39.57149 -7.30824  1.000 33.79761 ? 57  LEU A C    1 
ATOM   843  O O    . LEU A 1 57  ? -23.24175 -40.44448 -7.71170  1.000 32.29495 ? 57  LEU A O    1 
ATOM   844  C CB   . LEU A 1 57  ? -23.35843 -37.16354 -7.36784  1.000 32.95538 ? 57  LEU A CB   1 
ATOM   845  C CG   . LEU A 1 57  ? -23.27238 -35.81887 -8.08523  1.000 34.32100 ? 57  LEU A CG   1 
ATOM   846  C CD1  . LEU A 1 57  ? -22.56332 -34.80629 -7.20357  1.000 34.03903 ? 57  LEU A CD1  1 
ATOM   847  C CD2  . LEU A 1 57  ? -22.56049 -35.96515 -9.41988  1.000 34.55115 ? 57  LEU A CD2  1 
ATOM   848  H H    . LEU A 1 57  ? -25.78014 -37.16107 -7.70429  1.000 37.44276 ? 57  LEU A H    1 
ATOM   849  H HA   . LEU A 1 57  ? -23.81964 -38.37395 -8.95915  1.000 37.80919 ? 57  LEU A HA   1 
ATOM   850  H HB2  . LEU A 1 57  ? -23.75839 -36.99831 -6.49972  1.000 39.56923 ? 57  LEU A HB2  1 
ATOM   851  H HB3  . LEU A 1 57  ? -22.45046 -37.48691 -7.25867  1.000 39.56923 ? 57  LEU A HB3  1 
ATOM   852  H HG   . LEU A 1 57  ? -24.16810 -35.49337 -8.26587  1.000 41.20797 ? 57  LEU A HG   1 
ATOM   853  H HD11 . LEU A 1 57  ? -22.50000 -33.96315 -7.67897  1.000 40.86962 ? 57  LEU A HD11 1 
ATOM   854  H HD12 . LEU A 1 57  ? -23.07231 -34.68785 -6.38639  1.000 40.86962 ? 57  LEU A HD12 1 
ATOM   855  H HD13 . LEU A 1 57  ? -21.67520 -35.13606 -6.99524  1.000 40.86962 ? 57  LEU A HD13 1 
ATOM   856  H HD21 . LEU A 1 57  ? -22.35035 -35.08296 -9.76408  1.000 41.48415 ? 57  LEU A HD21 1 
ATOM   857  H HD22 . LEU A 1 57  ? -21.74399 -36.47204 -9.28840  1.000 41.48415 ? 57  LEU A HD22 1 
ATOM   858  H HD23 . LEU A 1 57  ? -23.14333 -36.43166 -10.03922 1.000 41.48415 ? 57  LEU A HD23 1 
ATOM   859  N N    . LEU A 1 58  ? -24.75719 -39.72571 -6.20682  1.000 33.97845 ? 58  LEU A N    1 
ATOM   860  C CA   . LEU A 1 58  ? -24.63957 -40.92579 -5.38654  1.000 33.26934 ? 58  LEU A CA   1 
ATOM   861  C C    . LEU A 1 58  ? -25.13361 -42.16133 -6.12437  1.000 35.11994 ? 58  LEU A C    1 
ATOM   862  O O    . LEU A 1 58  ? -24.65530 -43.27225 -5.86963  1.000 34.19066 ? 58  LEU A O    1 
ATOM   863  C CB   . LEU A 1 58  ? -25.42891 -40.73340 -4.09360  1.000 33.51046 ? 58  LEU A CB   1 
ATOM   864  C CG   . LEU A 1 58  ? -25.32206 -41.81935 -3.02611  1.000 30.14427 ? 58  LEU A CG   1 
ATOM   865  C CD1  . LEU A 1 58  ? -23.87775 -42.02084 -2.61844  1.000 33.17939 ? 58  LEU A CD1  1 
ATOM   866  C CD2  . LEU A 1 58  ? -26.17767 -41.43754 -1.83127  1.000 31.94071 ? 58  LEU A CD2  1 
ATOM   867  H H    . LEU A 1 58  ? -25.32869 -39.15289 -5.91553  1.000 40.79692 ? 58  LEU A H    1 
ATOM   868  H HA   . LEU A 1 58  ? -23.70668 -41.06802 -5.16208  1.000 39.94598 ? 58  LEU A HA   1 
ATOM   869  H HB2  . LEU A 1 58  ? -25.12718 -39.90778 -3.68347  1.000 40.23533 ? 58  LEU A HB2  1 
ATOM   870  H HB3  . LEU A 1 58  ? -26.36751 -40.66361 -4.32822  1.000 40.23533 ? 58  LEU A HB3  1 
ATOM   871  H HG   . LEU A 1 58  ? -25.64442 -42.66350 -3.37880  1.000 36.19591 ? 58  LEU A HG   1 
ATOM   872  H HD11 . LEU A 1 58  ? -23.45929 -41.15386 -2.49950  1.000 39.83804 ? 58  LEU A HD11 1 
ATOM   873  H HD12 . LEU A 1 58  ? -23.85099 -42.51804 -1.78600  1.000 39.83804 ? 58  LEU A HD12 1 
ATOM   874  H HD13 . LEU A 1 58  ? -23.41930 -42.51667 -3.31477  1.000 39.83804 ? 58  LEU A HD13 1 
ATOM   875  H HD21 . LEU A 1 58  ? -26.26385 -42.20627 -1.24602  1.000 38.35163 ? 58  LEU A HD21 1 
ATOM   876  H HD22 . LEU A 1 58  ? -25.75018 -40.70717 -1.35722  1.000 38.35163 ? 58  LEU A HD22 1 
ATOM   877  H HD23 . LEU A 1 58  ? -27.05285 -41.16093 -2.14505  1.000 38.35163 ? 58  LEU A HD23 1 
ATOM   878  N N    . ILE A 1 59  ? -26.08943 -41.98328 -7.03663  1.000 34.35917 ? 59  ILE A N    1 
ATOM   879  C CA   . ILE A 1 59  ? -26.69341 -43.09606 -7.75367  1.000 35.80196 ? 59  ILE A CA   1 
ATOM   880  C C    . ILE A 1 59  ? -25.69602 -43.81011 -8.65294  1.000 36.56687 ? 59  ILE A C    1 
ATOM   881  O O    . ILE A 1 59  ? -25.92118 -44.96599 -9.02997  1.000 38.52483 ? 59  ILE A O    1 
ATOM   882  C CB   . ILE A 1 59  ? -27.90741 -42.54593 -8.53019  1.000 35.27300 ? 59  ILE A CB   1 
ATOM   883  C CG1  . ILE A 1 59  ? -29.07918 -42.37523 -7.55554  1.000 37.95141 ? 59  ILE A CG1  1 
ATOM   884  C CG2  . ILE A 1 59  ? -28.23238 -43.41200 -9.74162  1.000 41.66092 ? 59  ILE A CG2  1 
ATOM   885  C CD1  . ILE A 1 59  ? -30.21575 -41.54725 -8.08629  1.000 42.52719 ? 59  ILE A CD1  1 
ATOM   886  H H    . ILE A 1 59  ? -26.40826 -41.21636 -7.25976  1.000 41.25379 ? 59  ILE A H    1 
ATOM   887  H HA   . ILE A 1 59  ? -27.00017 -43.77392 -7.13134  1.000 42.98513 ? 59  ILE A HA   1 
ATOM   888  H HB   . ILE A 1 59  ? -27.70076 -41.67226 -8.89749  1.000 42.35038 ? 59  ILE A HB   1 
ATOM   889  H HG12 . ILE A 1 59  ? -29.43188 -43.25267 -7.33966  1.000 45.56447 ? 59  ILE A HG12 1 
ATOM   890  H HG13 . ILE A 1 59  ? -28.75186 -41.94225 -6.75161  1.000 45.56447 ? 59  ILE A HG13 1 
ATOM   891  H HG21 . ILE A 1 59  ? -27.55387 -43.27256 -10.42066 1.000 50.01588 ? 59  ILE A HG21 1 
ATOM   892  H HG22 . ILE A 1 59  ? -28.24251 -44.34327 -9.47046  1.000 50.01588 ? 59  ILE A HG22 1 
ATOM   893  H HG23 . ILE A 1 59  ? -29.10274 -43.15848 -10.08672 1.000 50.01588 ? 59  ILE A HG23 1 
ATOM   894  H HD11 . ILE A 1 59  ? -30.96666 -41.61346 -7.47585  1.000 51.05540 ? 59  ILE A HD11 1 
ATOM   895  H HD12 . ILE A 1 59  ? -29.92752 -40.62378 -8.15718  1.000 51.05540 ? 59  ILE A HD12 1 
ATOM   896  H HD13 . ILE A 1 59  ? -30.46948 -41.88260 -8.96040  1.000 51.05540 ? 59  ILE A HD13 1 
ATOM   897  N N    . ARG A 1 60  ? -24.58824 -43.16192 -8.99471  1.000 37.02126 ? 60  ARG A N    1 
ATOM   898  C CA   . ARG A 1 60  ? -23.54641 -43.77798 -9.80238  1.000 39.98681 ? 60  ARG A CA   1 
ATOM   899  C C    . ARG A 1 60  ? -22.42882 -44.39238 -8.96504  1.000 36.50453 ? 60  ARG A C    1 
ATOM   900  O O    . ARG A 1 60  ? -21.43549 -44.85801 -9.53334  1.000 36.55196 ? 60  ARG A O    1 
ATOM   901  C CB   . ARG A 1 60  ? -22.96654 -42.74348 -10.77203 1.000 43.17110 ? 60  ARG A CB   1 
ATOM   902  C CG   . ARG A 1 60  ? -23.71225 -42.66005 -12.09647 1.000 50.08449 ? 60  ARG A CG   1 
ATOM   903  C CD   . ARG A 1 60  ? -23.39324 -41.37677 -12.84625 1.000 58.74082 ? 60  ARG A CD   1 
ATOM   904  N NE   . ARG A 1 60  ? -24.29944 -40.29390 -12.48169 1.000 67.15081 ? 60  ARG A NE   1 
ATOM   905  C CZ   . ARG A 1 60  ? -25.52287 -40.14456 -12.97275 1.000 74.08491 ? 60  ARG A CZ   1 
ATOM   906  N NH1  . ARG A 1 60  ? -26.02637 -40.99963 -13.84865 1.000 66.21271 ? 60  ARG A NH1  1 
ATOM   907  N NH2  . ARG A 1 60  ? -26.26173 -39.11372 -12.57217 1.000 56.62218 ? 60  ARG A NH2  1 
ATOM   908  H H    . ARG A 1 60  ? -24.41570 -42.35097 -8.76628  1.000 44.44829 ? 60  ARG A H    1 
ATOM   909  H HA   . ARG A 1 60  ? -23.94166 -44.49324 -10.32497 1.000 48.00695 ? 60  ARG A HA   1 
ATOM   910  H HB2  . ARG A 1 60  ? -23.00515 -41.86872 -10.35465 1.000 51.82810 ? 60  ARG A HB2  1 
ATOM   911  H HB3  . ARG A 1 60  ? -22.04546 -42.97867 -10.96491 1.000 51.82810 ? 60  ARG A HB3  1 
ATOM   912  H HG2  . ARG A 1 60  ? -23.45568 -43.40986 -12.65581 1.000 60.12417 ? 60  ARG A HG2  1 
ATOM   913  H HG3  . ARG A 1 60  ? -24.66721 -42.68339 -11.92790 1.000 60.12417 ? 60  ARG A HG3  1 
ATOM   914  H HD2  . ARG A 1 60  ? -22.48827 -41.09935 -12.63420 1.000 70.51176 ? 60  ARG A HD2  1 
ATOM   915  H HD3  . ARG A 1 60  ? -23.47709 -41.53448 -13.79967 1.000 70.51176 ? 60  ARG A HD3  1 
ATOM   916  H HE   . ARG A 1 60  ? -24.02245 -39.71366 -11.91055 1.000 80.60375 ? 60  ARG A HE   1 
ATOM   917  H HH11 . ARG A 1 60  ? -25.55801 -41.67102 -14.11223 1.000 79.47803 ? 60  ARG A HH11 1 
ATOM   918  H HH12 . ARG A 1 60  ? -26.82187 -40.88382 -14.15419 1.000 79.47803 ? 60  ARG A HH12 1 
ATOM   919  H HH21 . ARG A 1 60  ? -25.94508 -38.55373 -12.00143 1.000 67.96939 ? 60  ARG A HH21 1 
ATOM   920  H HH22 . ARG A 1 60  ? -27.05613 -39.00716 -12.88391 1.000 67.96939 ? 60  ARG A HH22 1 
ATOM   921  N N    . LYS A 1 61  ? -22.57032 -44.42035 -7.64105  1.000 34.73122 ? 61  LYS A N    1 
ATOM   922  C CA   . LYS A 1 61  ? -21.55958 -44.97073 -6.74865  1.000 32.40428 ? 61  LYS A CA   1 
ATOM   923  C C    . LYS A 1 61  ? -22.06429 -46.26560 -6.12561  1.000 33.81856 ? 61  LYS A C    1 
ATOM   924  O O    . LYS A 1 61  ? -23.22467 -46.35535 -5.71184  1.000 33.37684 ? 61  LYS A O    1 
ATOM   925  C CB   . LYS A 1 61  ? -21.19518 -43.97478 -5.64005  1.000 32.82119 ? 61  LYS A CB   1 
ATOM   926  C CG   . LYS A 1 61  ? -20.60266 -42.65622 -6.12702  1.000 33.02220 ? 61  LYS A CG   1 
ATOM   927  C CD   . LYS A 1 61  ? -19.38389 -42.84907 -7.01862  1.000 36.02451 ? 61  LYS A CD   1 
ATOM   928  C CE   . LYS A 1 61  ? -18.82303 -41.50469 -7.46023  1.000 36.56776 ? 61  LYS A CE   1 
ATOM   929  N NZ   . LYS A 1 61  ? -17.48858 -41.61990 -8.12253  1.000 39.06474 ? 61  LYS A NZ   1 
ATOM   930  H H    . LYS A 1 61  ? -23.26178 -44.11797 -7.22867  1.000 41.70025 ? 61  LYS A H    1 
ATOM   931  H HA   . LYS A 1 61  ? -20.75801 -45.16672 -7.25851  1.000 38.90791 ? 61  LYS A HA   1 
ATOM   932  H HB2  . LYS A 1 61  ? -21.99911 -43.76504 -5.13945  1.000 39.40820 ? 61  LYS A HB2  1 
ATOM   933  H HB3  . LYS A 1 61  ? -20.54040 -44.39020 -5.05730  1.000 39.40820 ? 61  LYS A HB3  1 
ATOM   934  H HG2  . LYS A 1 61  ? -21.27410 -42.17741 -6.63771  1.000 39.64941 ? 61  LYS A HG2  1 
ATOM   935  H HG3  . LYS A 1 61  ? -20.33126 -42.12898 -5.35938  1.000 39.64941 ? 61  LYS A HG3  1 
ATOM   936  H HD2  . LYS A 1 61  ? -18.69510 -43.32444 -6.52824  1.000 43.25219 ? 61  LYS A HD2  1 
ATOM   937  H HD3  . LYS A 1 61  ? -19.63612 -43.35241 -7.80851  1.000 43.25219 ? 61  LYS A HD3  1 
ATOM   938  H HE2  . LYS A 1 61  ? -19.43662 -41.09901 -8.09255  1.000 43.90409 ? 61  LYS A HE2  1 
ATOM   939  H HE3  . LYS A 1 61  ? -18.72253 -40.93375 -6.68252  1.000 43.90409 ? 61  LYS A HE3  1 
ATOM   940  H HZ1  . LYS A 1 61  ? -17.57779 -41.99807 -8.92324  1.000 46.90047 ? 61  LYS A HZ1  1 
ATOM   941  H HZ2  . LYS A 1 61  ? -17.12790 -40.81249 -8.22301  1.000 46.90047 ? 61  LYS A HZ2  1 
ATOM   942  H HZ3  . LYS A 1 61  ? -16.94450 -42.11956 -7.62612  1.000 46.90047 ? 61  LYS A HZ3  1 
ATOM   943  N N    . SER A 1 62  ? -21.18962 -47.26578 -6.06503  1.000 30.89511 ? 62  SER A N    1 
ATOM   944  C CA   . SER A 1 62  ? -21.46457 -48.52166 -5.38273  1.000 29.88058 ? 62  SER A CA   1 
ATOM   945  C C    . SER A 1 62  ? -20.51657 -48.65417 -4.19535  1.000 28.55297 ? 62  SER A C    1 
ATOM   946  O O    . SER A 1 62  ? -19.60430 -47.84484 -4.00568  1.000 27.96745 ? 62  SER A O    1 
ATOM   947  C CB   . SER A 1 62  ? -21.31822 -49.72290 -6.33130  1.000 30.45108 ? 62  SER A CB   1 
ATOM   948  O OG   . SER A 1 62  ? -22.02777 -49.52376 -7.54298  1.000 34.63901 ? 62  SER A OG   1 
ATOM   949  H H    . SER A 1 62  ? -20.40813 -47.23706 -6.42287  1.000 37.09691 ? 62  SER A H    1 
ATOM   950  H HA   . SER A 1 62  ? -22.37997 -48.52434 -5.06190  1.000 35.87948 ? 62  SER A HA   1 
ATOM   951  H HB2  . SER A 1 62  ? -20.37821 -49.84615 -6.53646  1.000 36.56407 ? 62  SER A HB2  1 
ATOM   952  H HB3  . SER A 1 62  ? -21.66802 -50.51315 -5.89078  1.000 36.56407 ? 62  SER A HB3  1 
ATOM   953  H HG   . SER A 1 62  ? -22.84280 -49.40008 -7.38164  1.000 41.58959 ? 62  SER A HG   1 
ATOM   954  N N    . ASN A 1 63  ? -20.73758 -49.70072 -3.39461  1.000 26.43594 ? 63  ASN A N    1 
ATOM   955  C CA   . ASN A 1 63  ? -19.94039 -49.89667 -2.18604  1.000 24.56028 ? 63  ASN A CA   1 
ATOM   956  C C    . ASN A 1 63  ? -18.44509 -49.92456 -2.49158  1.000 29.17195 ? 63  ASN A C    1 
ATOM   957  O O    . ASN A 1 63  ? -17.64435 -49.33561 -1.75523  1.000 25.35718 ? 63  ASN A O    1 
ATOM   958  C CB   . ASN A 1 63  ? -20.35238 -51.19468 -1.48623  1.000 28.39108 ? 63  ASN A CB   1 
ATOM   959  C CG   . ASN A 1 63  ? -21.74505 -51.12669 -0.87235  1.000 32.34832 ? 63  ASN A CG   1 
ATOM   960  O OD1  . ASN A 1 63  ? -22.29382 -50.04546 -0.64421  1.000 25.39039 ? 63  ASN A OD1  1 
ATOM   961  N ND2  . ASN A 1 63  ? -22.31718 -52.29484 -0.58823  1.000 30.11479 ? 63  ASN A ND2  1 
ATOM   962  H H    . ASN A 1 63  ? -21.33606 -50.30373 -3.52802  1.000 31.74590 ? 63  ASN A H    1 
ATOM   963  H HA   . ASN A 1 63  ? -20.11315 -49.15296 -1.58775  1.000 29.49512 ? 63  ASN A HA   1 
ATOM   964  H HB2  . ASN A 1 63  ? -20.34653 -51.91693 -2.13370  1.000 34.09207 ? 63  ASN A HB2  1 
ATOM   965  H HB3  . ASN A 1 63  ? -19.72111 -51.38241 -0.77408  1.000 34.09207 ? 63  ASN A HB3  1 
ATOM   966  H HD21 . ASN A 1 63  ? -23.10332 -52.31523 -0.24014  1.000 36.16052 ? 63  ASN A HD21 1 
ATOM   967  H HD22 . ASN A 1 63  ? -21.90060 -53.02899 -0.75281  1.000 36.16052 ? 63  ASN A HD22 1 
ATOM   968  N N    . HIS A 1 64  ? -18.04522 -50.61192 -3.56620  1.000 28.80465 ? 64  HIS A N    1 
ATOM   969  C CA   . HIS A 1 64  ? -16.62398 -50.75945 -3.86891  1.000 29.14357 ? 64  HIS A CA   1 
ATOM   970  C C    . HIS A 1 64  ? -15.98592 -49.46758 -4.36674  1.000 27.34360 ? 64  HIS A C    1 
ATOM   971  O O    . HIS A 1 64  ? -14.75729 -49.41634 -4.49132  1.000 28.38040 ? 64  HIS A O    1 
ATOM   972  C CB   . HIS A 1 64  ? -16.40600 -51.87774 -4.89959  1.000 29.79372 ? 64  HIS A CB   1 
ATOM   973  C CG   . HIS A 1 64  ? -16.98401 -51.58768 -6.24971  1.000 31.78997 ? 64  HIS A CG   1 
ATOM   974  N ND1  . HIS A 1 64  ? -18.20600 -52.07848 -6.65603  1.000 32.31792 ? 64  HIS A ND1  1 
ATOM   975  C CD2  . HIS A 1 64  ? -16.50142 -50.87054 -7.29210  1.000 32.81988 ? 64  HIS A CD2  1 
ATOM   976  C CE1  . HIS A 1 64  ? -18.45610 -51.66807 -7.88654  1.000 35.03376 ? 64  HIS A CE1  1 
ATOM   977  N NE2  . HIS A 1 64  ? -17.43772 -50.93306 -8.29546  1.000 33.55585 ? 64  HIS A NE2  1 
ATOM   978  H H    . HIS A 1 64  ? -18.57224 -50.99631 -4.12665  1.000 34.58836 ? 64  HIS A H    1 
ATOM   979  H HA   . HIS A 1 64  ? -16.16738 -51.02021 -3.05379  1.000 34.99506 ? 64  HIS A HA   1 
ATOM   980  H HB2  . HIS A 1 64  ? -15.45232 -52.01545 -5.01109  1.000 35.77524 ? 64  HIS A HB2  1 
ATOM   981  H HB3  . HIS A 1 64  ? -16.82204 -52.68943 -4.56949  1.000 35.77524 ? 64  HIS A HB3  1 
ATOM   982  H HD2  . HIS A 1 64  ? -15.68840 -50.42005 -7.32296  1.000 39.40663 ? 64  HIS A HD2  1 
ATOM   983  H HE1  . HIS A 1 64  ? -19.21931 -51.86341 -8.38076  1.000 42.06329 ? 64  HIS A HE1  1 
ATOM   984  H HE2  . HIS A 1 64  ? -17.37149 -50.55494 -9.06504  1.000 40.28979 ? 64  HIS A HE2  1 
ATOM   985  N N    . ASN A 1 65  ? -16.77528 -48.42939 -4.64823  1.000 27.74503 ? 65  ASN A N    1 
ATOM   986  C CA   . ASN A 1 65  ? -16.21585 -47.13486 -5.01747  1.000 27.60074 ? 65  ASN A CA   1 
ATOM   987  C C    . ASN A 1 65  ? -15.77300 -46.31803 -3.81109  1.000 27.71484 ? 65  ASN A C    1 
ATOM   988  O O    . ASN A 1 65  ? -15.08931 -45.30429 -3.99024  1.000 28.67177 ? 65  ASN A O    1 
ATOM   989  C CB   . ASN A 1 65  ? -17.23263 -46.32026 -5.82157  1.000 28.13834 ? 65  ASN A CB   1 
ATOM   990  C CG   . ASN A 1 65  ? -17.57857 -46.96329 -7.14860  1.000 33.82592 ? 65  ASN A CG   1 
ATOM   991  O OD1  . ASN A 1 65  ? -18.75180 -47.12641 -7.48441  1.000 30.51186 ? 65  ASN A OD1  1 
ATOM   992  N ND2  . ASN A 1 65  ? -16.55595 -47.33241 -7.91260  1.000 28.62781 ? 65  ASN A ND2  1 
ATOM   993  H H    . ASN A 1 65  ? -17.63483 -48.45200 -4.63173  1.000 33.31681 ? 65  ASN A H    1 
ATOM   994  H HA   . ASN A 1 65  ? -15.44332 -47.29040 -5.58307  1.000 33.14367 ? 65  ASN A HA   1 
ATOM   995  H HB2  . ASN A 1 65  ? -18.05011 -46.23730 -5.30607  1.000 33.78878 ? 65  ASN A HB2  1 
ATOM   996  H HB3  . ASN A 1 65  ? -16.86300 -45.44160 -6.00109  1.000 33.78878 ? 65  ASN A HB3  1 
ATOM   997  H HD21 . ASN A 1 65  ? -16.70061 -47.70205 -8.67552  1.000 34.37615 ? 65  ASN A HD21 1 
ATOM   998  H HD22 . ASN A 1 65  ? -15.74945 -47.20167 -7.64414  1.000 34.37615 ? 65  ASN A HD22 1 
ATOM   999  N N    . PHE A 1 66  ? -16.14851 -46.72659 -2.59924  1.000 27.99533 ? 66  PHE A N    1 
ATOM   1000 C CA   . PHE A 1 66  ? -15.76915 -46.03262 -1.37003  1.000 26.39210 ? 66  PHE A CA   1 
ATOM   1001 C C    . PHE A 1 66  ? -14.57188 -46.75371 -0.76168  1.000 24.34049 ? 66  PHE A C    1 
ATOM   1002 O O    . PHE A 1 66  ? -14.71619 -47.80824 -0.13802  1.000 28.53248 ? 66  PHE A O    1 
ATOM   1003 C CB   . PHE A 1 66  ? -16.93648 -45.97859 -0.39004  1.000 25.57724 ? 66  PHE A CB   1 
ATOM   1004 C CG   . PHE A 1 66  ? -18.09449 -45.15827 -0.87277  1.000 25.24612 ? 66  PHE A CG   1 
ATOM   1005 C CD1  . PHE A 1 66  ? -18.03105 -43.77291 -0.86661  1.000 28.59300 ? 66  PHE A CD1  1 
ATOM   1006 C CD2  . PHE A 1 66  ? -19.25064 -45.76866 -1.31986  1.000 24.64869 ? 66  PHE A CD2  1 
ATOM   1007 C CE1  . PHE A 1 66  ? -19.09547 -43.01537 -1.30743  1.000 25.48147 ? 66  PHE A CE1  1 
ATOM   1008 C CE2  . PHE A 1 66  ? -20.31946 -45.01523 -1.76355  1.000 27.80115 ? 66  PHE A CE2  1 
ATOM   1009 C CZ   . PHE A 1 66  ? -20.24090 -43.63575 -1.75692  1.000 27.66236 ? 66  PHE A CZ   1 
ATOM   1010 H H    . PHE A 1 66  ? -16.63600 -47.42140 -2.46069  1.000 33.61717 ? 66  PHE A H    1 
ATOM   1011 H HA   . PHE A 1 66  ? -15.50624 -45.12517 -1.58983  1.000 31.69329 ? 66  PHE A HA   1 
ATOM   1012 H HB2  . PHE A 1 66  ? -17.25685 -46.88125 -0.23687  1.000 30.71547 ? 66  PHE A HB2  1 
ATOM   1013 H HB3  . PHE A 1 66  ? -16.62621 -45.59081 0.44318   1.000 30.71547 ? 66  PHE A HB3  1 
ATOM   1014 H HD1  . PHE A 1 66  ? -17.26121 -43.34969 -0.56143  1.000 34.33438 ? 66  PHE A HD1  1 
ATOM   1015 H HD2  . PHE A 1 66  ? -19.30961 -46.69678 -1.32201  1.000 29.60121 ? 66  PHE A HD2  1 
ATOM   1016 H HE1  . PHE A 1 66  ? -19.04045 -42.08702 -1.30141  1.000 30.60054 ? 66  PHE A HE1  1 
ATOM   1017 H HE2  . PHE A 1 66  ? -21.09151 -45.43595 -2.06657  1.000 33.38416 ? 66  PHE A HE2  1 
ATOM   1018 H HZ   . PHE A 1 66  ? -20.95983 -43.12682 -2.05529  1.000 33.21761 ? 66  PHE A HZ   1 
ATOM   1019 N N    . LEU A 1 67  ? -13.38881 -46.17857 -0.94513  1.000 24.89753 ? 67  LEU A N    1 
ATOM   1020 C CA   . LEU A 1 67  ? -12.15732 -46.72697 -0.39172  1.000 24.99538 ? 67  LEU A CA   1 
ATOM   1021 C C    . LEU A 1 67  ? -11.97003 -46.19674 1.02332   1.000 25.53703 ? 67  LEU A C    1 
ATOM   1022 O O    . LEU A 1 67  ? -11.76615 -44.99321 1.22087   1.000 23.45512 ? 67  LEU A O    1 
ATOM   1023 C CB   . LEU A 1 67  ? -10.96193 -46.35583 -1.26435  1.000 25.83075 ? 67  LEU A CB   1 
ATOM   1024 C CG   . LEU A 1 67  ? -11.06452 -46.75381 -2.73725  1.000 29.69593 ? 67  LEU A CG   1 
ATOM   1025 C CD1  . LEU A 1 67  ? -9.88262  -46.21268 -3.52989  1.000 34.01649 ? 67  LEU A CD1  1 
ATOM   1026 C CD2  . LEU A 1 67  ? -11.15724 -48.26409 -2.87297  1.000 33.18142 ? 67  LEU A CD2  1 
ATOM   1027 H H    . LEU A 1 67  ? -13.27160 -45.45543 -1.39559  1.000 29.89981 ? 67  LEU A H    1 
ATOM   1028 H HA   . LEU A 1 67  ? -12.23131 -47.69346 -0.35534  1.000 30.01723 ? 67  LEU A HA   1 
ATOM   1029 H HB2  . LEU A 1 67  ? -10.85115 -45.39268 -1.23318  1.000 31.01968 ? 67  LEU A HB2  1 
ATOM   1030 H HB3  . LEU A 1 67  ? -10.17497 -46.79217 -0.90213  1.000 31.01968 ? 67  LEU A HB3  1 
ATOM   1031 H HG   . LEU A 1 67  ? -11.87137 -46.36659 -3.11135  1.000 35.65789 ? 67  LEU A HG   1 
ATOM   1032 H HD11 . LEU A 1 67  ? -9.97920  -46.47413 -4.45898  1.000 40.84256 ? 67  LEU A HD11 1 
ATOM   1033 H HD12 . LEU A 1 67  ? -9.87045  -45.24543 -3.45799  1.000 40.84256 ? 67  LEU A HD12 1 
ATOM   1034 H HD13 . LEU A 1 67  ? -9.06274  -46.58176 -3.16592  1.000 40.84256 ? 67  LEU A HD13 1 
ATOM   1035 H HD21 . LEU A 1 67  ? -11.16424 -48.49671 -3.81464  1.000 39.84048 ? 67  LEU A HD21 1 
ATOM   1036 H HD22 . LEU A 1 67  ? -10.38993 -48.66794 -2.43818  1.000 39.84048 ? 67  LEU A HD22 1 
ATOM   1037 H HD23 . LEU A 1 67  ? -11.97538 -48.56948 -2.45073  1.000 39.84048 ? 67  LEU A HD23 1 
ATOM   1038 N N    . VAL A 1 68  ? -12.02461 -47.09815 1.99885   1.000 23.13634 ? 68  VAL A N    1 
ATOM   1039 C CA   . VAL A 1 68  ? -11.91480 -46.76195 3.41140   1.000 23.17959 ? 68  VAL A CA   1 
ATOM   1040 C C    . VAL A 1 68  ? -10.68811 -47.46974 3.96512   1.000 30.50691 ? 68  VAL A C    1 
ATOM   1041 O O    . VAL A 1 68  ? -10.53380 -48.68506 3.79211   1.000 26.75494 ? 68  VAL A O    1 
ATOM   1042 C CB   . VAL A 1 68  ? -13.18286 -47.16157 4.18723   1.000 26.36828 ? 68  VAL A CB   1 
ATOM   1043 C CG1  . VAL A 1 68  ? -13.08584 -46.72243 5.63727   1.000 27.31106 ? 68  VAL A CG1  1 
ATOM   1044 C CG2  . VAL A 1 68  ? -14.41217 -46.57494 3.51842   1.000 24.40304 ? 68  VAL A CG2  1 
ATOM   1045 H H    . VAL A 1 68  ? -12.12850 -47.94053 1.86031   1.000 27.78639 ? 68  VAL A H    1 
ATOM   1046 H HA   . VAL A 1 68  ? -11.78891 -45.80549 3.51263   1.000 27.83828 ? 68  VAL A HA   1 
ATOM   1047 H HB   . VAL A 1 68  ? -13.26860 -48.12775 4.18009   1.000 31.66472 ? 68  VAL A HB   1 
ATOM   1048 H HG11 . VAL A 1 68  ? -12.30663 -47.13569 6.04094   1.000 32.79604 ? 68  VAL A HG11 1 
ATOM   1049 H HG12 . VAL A 1 68  ? -13.00223 -45.75659 5.66982   1.000 32.79604 ? 68  VAL A HG12 1 
ATOM   1050 H HG13 . VAL A 1 68  ? -13.88813 -47.00097 6.10595   1.000 32.79604 ? 68  VAL A HG13 1 
ATOM   1051 H HG21 . VAL A 1 68  ? -15.07687 -46.37760 4.19675   1.000 29.30643 ? 68  VAL A HG21 1 
ATOM   1052 H HG22 . VAL A 1 68  ? -14.16114 -45.76086 3.05456   1.000 29.30643 ? 68  VAL A HG22 1 
ATOM   1053 H HG23 . VAL A 1 68  ? -14.76600 -47.22010 2.88638   1.000 29.30643 ? 68  VAL A HG23 1 
ATOM   1054 N N    . GLN A 1 69  ? -9.83192  -46.71435 4.64837   1.000 27.33045 ? 69  GLN A N    1 
ATOM   1055 C CA   . GLN A 1 69  ? -8.50857  -47.18913 5.03549   1.000 30.35088 ? 69  GLN A CA   1 
ATOM   1056 C C    . GLN A 1 69  ? -8.21489  -46.72661 6.45445   1.000 30.93878 ? 69  GLN A C    1 
ATOM   1057 O O    . GLN A 1 69  ? -8.19047  -45.52223 6.72502   1.000 30.18961 ? 69  GLN A O    1 
ATOM   1058 C CB   . GLN A 1 69  ? -7.45734  -46.67257 4.04480   1.000 30.89412 ? 69  GLN A CB   1 
ATOM   1059 C CG   . GLN A 1 69  ? -6.02394  -47.00810 4.37015   1.000 38.30422 ? 69  GLN A CG   1 
ATOM   1060 C CD   . GLN A 1 69  ? -5.12687  -46.90761 3.15018   1.000 37.77683 ? 69  GLN A CD   1 
ATOM   1061 O OE1  . GLN A 1 69  ? -5.57867  -46.56123 2.05930   1.000 40.26215 ? 69  GLN A OE1  1 
ATOM   1062 N NE2  . GLN A 1 69  ? -3.85038  -47.21244 3.32908   1.000 44.72172 ? 69  GLN A NE2  1 
ATOM   1063 H H    . GLN A 1 69  ? -9.99823  -45.90995 4.90307   1.000 32.81932 ? 69  GLN A H    1 
ATOM   1064 H HA   . GLN A 1 69  ? -8.48257  -48.15877 5.03951   1.000 36.44384 ? 69  GLN A HA   1 
ATOM   1065 H HB2  . GLN A 1 69  ? -7.64992  -47.05175 3.17300   1.000 37.09572 ? 69  GLN A HB2  1 
ATOM   1066 H HB3  . GLN A 1 69  ? -7.52436  -45.70558 4.00814   1.000 37.09572 ? 69  GLN A HB3  1 
ATOM   1067 H HG2  . GLN A 1 69  ? -5.69527  -46.38854 5.04023   1.000 45.98784 ? 69  GLN A HG2  1 
ATOM   1068 H HG3  . GLN A 1 69  ? -5.97731  -47.91655 4.70697   1.000 45.98784 ? 69  GLN A HG3  1 
ATOM   1069 H HE21 . GLN A 1 69  ? -3.30166  -47.17093 2.66819   1.000 53.68884 ? 69  GLN A HE21 1 
ATOM   1070 H HE22 . GLN A 1 69  ? -3.57028  -47.45188 4.10614   1.000 53.68884 ? 69  GLN A HE22 1 
ATOM   1071 N N    . ALA A 1 70  ? -8.01491  -47.68462 7.35859   1.000 32.47259 ? 70  ALA A N    1 
ATOM   1072 C CA   . ALA A 1 70  ? -7.71536  -47.42232 8.76575   1.000 33.40576 ? 70  ALA A CA   1 
ATOM   1073 C C    . ALA A 1 70  ? -6.23053  -47.70632 8.96983   1.000 40.87270 ? 70  ALA A C    1 
ATOM   1074 O O    . ALA A 1 70  ? -5.81599  -48.86744 9.03735   1.000 39.57597 ? 70  ALA A O    1 
ATOM   1075 C CB   . ALA A 1 70  ? -8.58597  -48.28177 9.67856   1.000 38.13125 ? 70  ALA A CB   1 
ATOM   1076 H H    . ALA A 1 70  ? -8.04887  -48.52385 7.17383   1.000 38.98989 ? 70  ALA A H    1 
ATOM   1077 H HA   . ALA A 1 70  ? -7.89005  -46.49123 8.97420   1.000 40.10968 ? 70  ALA A HA   1 
ATOM   1078 H HB1  . ALA A 1 70  ? -9.51691  -48.15677 9.43643   1.000 45.78028 ? 70  ALA A HB1  1 
ATOM   1079 H HB2  . ALA A 1 70  ? -8.33736  -49.21274 9.56721   1.000 45.78028 ? 70  ALA A HB2  1 
ATOM   1080 H HB3  . ALA A 1 70  ? -8.44402  -48.00926 10.59860  1.000 45.78028 ? 70  ALA A HB3  1 
ATOM   1081 N N    . GLY A 1 71  ? -5.43323  -46.64722 9.07587   1.000 38.61517 ? 71  GLY A N    1 
ATOM   1082 C CA   . GLY A 1 71  ? -3.99467  -46.82844 8.99207   1.000 39.96217 ? 71  GLY A CA   1 
ATOM   1083 C C    . GLY A 1 71  ? -3.62397  -47.29936 7.60143   1.000 41.22857 ? 71  GLY A C    1 
ATOM   1084 O O    . GLY A 1 71  ? -4.08635  -46.75500 6.59350   1.000 42.37518 ? 71  GLY A O    1 
ATOM   1085 H H    . GLY A 1 71  ? -5.69461  -45.83638 9.19340   1.000 46.36098 ? 71  GLY A H    1 
ATOM   1086 H HA2  . GLY A 1 71  ? -3.54267  -45.98971 9.17407   1.000 47.97738 ? 71  GLY A HA2  1 
ATOM   1087 H HA3  . GLY A 1 71  ? -3.70462  -47.49037 9.63908   1.000 47.97738 ? 71  GLY A HA3  1 
ATOM   1088 N N    . ASN A 1 72  ? -2.78287  -48.32743 7.53657   1.000 47.92851 ? 72  ASN A N    1 
ATOM   1089 C CA   . ASN A 1 72  ? -2.47879  -49.00325 6.28309   1.000 47.43218 ? 72  ASN A CA   1 
ATOM   1090 C C    . ASN A 1 72  ? -3.42244  -50.16926 6.00936   1.000 46.70709 ? 72  ASN A C    1 
ATOM   1091 O O    . ASN A 1 72  ? -3.20152  -50.91936 5.05320   1.000 47.39547 ? 72  ASN A O    1 
ATOM   1092 C CB   . ASN A 1 72  ? -1.02995  -49.50050 6.28981   1.000 49.22108 ? 72  ASN A CB   1 
ATOM   1093 H H    . ASN A 1 72  ? -2.37064  -48.65536 8.21637   1.000 57.53699 ? 72  ASN A H    1 
ATOM   1094 H HA   . ASN A 1 72  ? -2.56919  -48.36605 5.55735   1.000 56.94140 ? 72  ASN A HA   1 
ATOM   1095 N N    . VAL A 1 73  ? -4.46674  -50.33155 6.81933   1.000 43.83811 ? 73  VAL A N    1 
ATOM   1096 C CA   . VAL A 1 73  ? -5.36358  -51.48086 6.75301   1.000 40.57960 ? 73  VAL A CA   1 
ATOM   1097 C C    . VAL A 1 73  ? -6.67758  -51.05384 6.11248   1.000 40.65260 ? 73  VAL A C    1 
ATOM   1098 O O    . VAL A 1 73  ? -7.32112  -50.09920 6.56650   1.000 35.91411 ? 73  VAL A O    1 
ATOM   1099 C CB   . VAL A 1 73  ? -5.58822  -52.07794 8.15374   1.000 42.95049 ? 73  VAL A CB   1 
ATOM   1100 C CG1  . VAL A 1 73  ? -6.96690  -52.71257 8.27629   1.000 44.89853 ? 73  VAL A CG1  1 
ATOM   1101 C CG2  . VAL A 1 73  ? -4.49787  -53.10201 8.46535   1.000 46.19270 ? 73  VAL A CG2  1 
ATOM   1102 H H    . VAL A 1 73  ? -4.68162  -49.77036 7.43455   1.000 52.62851 ? 73  VAL A H    1 
ATOM   1103 H HA   . VAL A 1 73  ? -4.97389  -52.16111 6.18177   1.000 48.71830 ? 73  VAL A HA   1 
ATOM   1104 H HB   . VAL A 1 73  ? -5.54197  -51.36037 8.80478   1.000 51.56336 ? 73  VAL A HB   1 
ATOM   1105 H HG11 . VAL A 1 73  ? -7.00164  -53.23743 9.09128   1.000 53.90102 ? 73  VAL A HG11 1 
ATOM   1106 H HG12 . VAL A 1 73  ? -7.63602  -52.01093 8.30595   1.000 53.90102 ? 73  VAL A HG12 1 
ATOM   1107 H HG13 . VAL A 1 73  ? -7.12086  -53.28420 7.50790   1.000 53.90102 ? 73  VAL A HG13 1 
ATOM   1108 H HG21 . VAL A 1 73  ? -3.83126  -53.07773 7.76112   1.000 55.45402 ? 73  VAL A HG21 1 
ATOM   1109 H HG22 . VAL A 1 73  ? -4.08868  -52.87869 9.31599   1.000 55.45402 ? 73  VAL A HG22 1 
ATOM   1110 H HG23 . VAL A 1 73  ? -4.89761  -53.98457 8.51214   1.000 55.45402 ? 73  VAL A HG23 1 
ATOM   1111 N N    . GLN A 1 74  ? -7.07881  -51.76940 5.06608   1.000 37.43039 ? 74  GLN A N    1 
ATOM   1112 C CA   . GLN A 1 74  ? -8.27738  -51.43621 4.31278   1.000 35.39142 ? 74  GLN A CA   1 
ATOM   1113 C C    . GLN A 1 74  ? -9.51193  -52.04619 4.96743   1.000 37.55640 ? 74  GLN A C    1 
ATOM   1114 O O    . GLN A 1 74  ? -9.45764  -53.13128 5.55347   1.000 32.99316 ? 74  GLN A O    1 
ATOM   1115 C CB   . GLN A 1 74  ? -8.15608  -51.94161 2.87471   1.000 38.67694 ? 74  GLN A CB   1 
ATOM   1116 C CG   . GLN A 1 74  ? -8.95508  -51.14100 1.86357   1.000 35.13403 ? 74  GLN A CG   1 
ATOM   1117 C CD   . GLN A 1 74  ? -8.28751  -49.82432 1.50841   1.000 37.44329 ? 74  GLN A CD   1 
ATOM   1118 O OE1  . GLN A 1 74  ? -7.14094  -49.57847 1.88179   1.000 36.60006 ? 74  GLN A OE1  1 
ATOM   1119 N NE2  . GLN A 1 74  ? -9.00110  -48.97369 0.77910   1.000 30.67655 ? 74  GLN A NE2  1 
ATOM   1120 H H    . GLN A 1 74  ? -6.66560  -52.46307 4.76997   1.000 44.93925 ? 74  GLN A H    1 
ATOM   1121 H HA   . GLN A 1 74  ? -8.38967  -50.47289 4.29529   1.000 42.49248 ? 74  GLN A HA   1 
ATOM   1122 H HB2  . GLN A 1 74  ? -7.22369  -51.90255 2.61010   1.000 46.43511 ? 74  GLN A HB2  1 
ATOM   1123 H HB3  . GLN A 1 74  ? -8.47254  -52.85789 2.84051   1.000 46.43511 ? 74  GLN A HB3  1 
ATOM   1124 H HG2  . GLN A 1 74  ? -9.04830  -51.66060 1.04979   1.000 42.18361 ? 74  GLN A HG2  1 
ATOM   1125 H HG3  . GLN A 1 74  ? -9.82984  -50.94492 2.23403   1.000 42.18361 ? 74  GLN A HG3  1 
ATOM   1126 H HE21 . GLN A 1 74  ? -9.79847  -49.18189 0.53322   1.000 36.83463 ? 74  GLN A HE21 1 
ATOM   1127 H HE22 . GLN A 1 74  ? -8.66571  -48.21480 0.55284   1.000 36.83463 ? 74  GLN A HE22 1 
ATOM   1128 N N    . LEU A 1 75  ? -10.63310 -51.33726 4.85785   1.000 30.61457 ? 75  LEU A N    1 
ATOM   1129 C CA   . LEU A 1 75  ? -11.91450 -51.80882 5.36058   1.000 30.80801 ? 75  LEU A CA   1 
ATOM   1130 C C    . LEU A 1 75  ? -12.83886 -52.14043 4.19636   1.000 34.12960 ? 75  LEU A C    1 
ATOM   1131 O O    . LEU A 1 75  ? -12.81506 -51.48009 3.15337   1.000 33.55232 ? 75  LEU A O    1 
ATOM   1132 C CB   . LEU A 1 75  ? -12.58199 -50.76498 6.26233   1.000 27.39400 ? 75  LEU A CB   1 
ATOM   1133 C CG   . LEU A 1 75  ? -11.75440 -50.25070 7.44116   1.000 32.10976 ? 75  LEU A CG   1 
ATOM   1134 C CD1  . LEU A 1 75  ? -12.61383 -49.37394 8.34910   1.000 27.56309 ? 75  LEU A CD1  1 
ATOM   1135 C CD2  . LEU A 1 75  ? -11.13941 -51.39372 8.23689   1.000 36.50453 ? 75  LEU A CD2  1 
ATOM   1136 H H    . LEU A 1 75  ? -10.67440 -50.56242 4.48701   1.000 36.76026 ? 75  LEU A H    1 
ATOM   1137 H HA   . LEU A 1 75  ? -11.77443 -52.61274 5.88498   1.000 36.99239 ? 75  LEU A HA   1 
ATOM   1138 H HB2  . LEU A 1 75  ? -12.80743 -49.99609 5.71562   1.000 32.89557 ? 75  LEU A HB2  1 
ATOM   1139 H HB3  . LEU A 1 75  ? -13.38863 -51.15816 6.63061   1.000 32.89557 ? 75  LEU A HB3  1 
ATOM   1140 H HG   . LEU A 1 75  ? -11.02444 -49.71654 7.09082   1.000 38.55449 ? 75  LEU A HG   1 
ATOM   1141 H HD11 . LEU A 1 75  ? -12.05942 -49.01744 9.06075   1.000 33.09848 ? 75  LEU A HD11 1 
ATOM   1142 H HD12 . LEU A 1 75  ? -12.98735 -48.64784 7.82549   1.000 33.09848 ? 75  LEU A HD12 1 
ATOM   1143 H HD13 . LEU A 1 75  ? -13.32794 -49.91255 8.72438   1.000 33.09848 ? 75  LEU A HD13 1 
ATOM   1144 H HD21 . LEU A 1 75  ? -11.84783 -51.97814 8.54913   1.000 43.82821 ? 75  LEU A HD21 1 
ATOM   1145 H HD22 . LEU A 1 75  ? -10.53234 -51.88703 7.66330   1.000 43.82821 ? 75  LEU A HD22 1 
ATOM   1146 H HD23 . LEU A 1 75  ? -10.65537 -51.02726 8.99341   1.000 43.82821 ? 75  LEU A HD23 1 
ATOM   1147 N N    . ARG A 1 76  ? -13.66767 -53.16154 4.39276   1.000 26.14499 ? 76  ARG A N    1 
ATOM   1148 C CA   . ARG A 1 76  ? -14.57969 -53.64564 3.36462   1.000 32.19188 ? 76  ARG A CA   1 
ATOM   1149 C C    . ARG A 1 76  ? -15.94751 -53.00884 3.57800   1.000 29.24156 ? 76  ARG A C    1 
ATOM   1150 O O    . ARG A 1 76  ? -16.53307 -53.13523 4.65861   1.000 29.01786 ? 76  ARG A O    1 
ATOM   1151 C CB   . ARG A 1 76  ? -14.67559 -55.17080 3.40523   1.000 32.80738 ? 76  ARG A CB   1 
ATOM   1152 C CG   . ARG A 1 76  ? -15.54792 -55.77986 2.31846   1.000 31.68343 ? 76  ARG A CG   1 
ATOM   1153 C CD   . ARG A 1 76  ? -15.54665 -57.30879 2.40344   1.000 35.45922 ? 76  ARG A CD   1 
ATOM   1154 N NE   . ARG A 1 76  ? -14.20031 -57.86157 2.29404   1.000 34.72463 ? 76  ARG A NE   1 
ATOM   1155 C CZ   . ARG A 1 76  ? -13.56417 -58.06952 1.14849   1.000 34.51670 ? 76  ARG A CZ   1 
ATOM   1156 N NH1  . ARG A 1 76  ? -14.12985 -57.79870 -0.01652  1.000 34.04980 ? 76  ARG A NH1  1 
ATOM   1157 N NH2  . ARG A 1 76  ? -12.32550 -58.55420 1.17222   1.000 33.53337 ? 76  ARG A NH2  1 
ATOM   1158 H H    . ARG A 1 76  ? -13.72024 -53.59940 5.13107   1.000 31.39677 ? 76  ARG A H    1 
ATOM   1159 H HA   . ARG A 1 76  ? -14.25609 -53.38436 2.48831   1.000 38.65303 ? 76  ARG A HA   1 
ATOM   1160 H HB2  . ARG A 1 76  ? -13.78371 -55.53872 3.30483   1.000 39.39163 ? 76  ARG A HB2  1 
ATOM   1161 H HB3  . ARG A 1 76  ? -15.04851 -55.43373 4.26121   1.000 39.39163 ? 76  ARG A HB3  1 
ATOM   1162 H HG2  . ARG A 1 76  ? -16.46023 -55.46768 2.42393   1.000 38.04289 ? 76  ARG A HG2  1 
ATOM   1163 H HG3  . ARG A 1 76  ? -15.20720 -55.52088 1.44797   1.000 38.04289 ? 76  ARG A HG3  1 
ATOM   1164 H HD2  . ARG A 1 76  ? -15.91752 -57.58127 3.25732   1.000 42.57384 ? 76  ARG A HD2  1 
ATOM   1165 H HD3  . ARG A 1 76  ? -16.08184 -57.66913 1.67913   1.000 42.57384 ? 76  ARG A HD3  1 
ATOM   1166 H HE   . ARG A 1 76  ? -13.79123 -58.06661 3.02219   1.000 41.69234 ? 76  ARG A HE   1 
ATOM   1167 H HH11 . ARG A 1 76  ? -14.92823 -57.48012 -0.04316  1.000 40.88253 ? 76  ARG A HH11 1 
ATOM   1168 H HH12 . ARG A 1 76  ? -13.69917 -57.94125 -0.74713  1.000 40.88253 ? 76  ARG A HH12 1 
ATOM   1169 H HH21 . ARG A 1 76  ? -11.94644 -58.72888 1.92415   1.000 40.26282 ? 76  ARG A HH21 1 
ATOM   1170 H HH22 . ARG A 1 76  ? -11.90381 -58.69284 0.43564   1.000 40.26282 ? 76  ARG A HH22 1 
ATOM   1171 N N    . VAL A 1 77  ? -16.45428 -52.33965 2.54607   1.000 29.16468 ? 77  VAL A N    1 
ATOM   1172 C CA   . VAL A 1 77  ? -17.69432 -51.57423 2.61996   1.000 32.29282 ? 77  VAL A CA   1 
ATOM   1173 C C    . VAL A 1 77  ? -18.82735 -52.45244 2.10590   1.000 32.58118 ? 77  VAL A C    1 
ATOM   1174 O O    . VAL A 1 77  ? -18.78766 -52.92176 0.96172   1.000 28.50610 ? 77  VAL A O    1 
ATOM   1175 C CB   . VAL A 1 77  ? -17.58879 -50.27029 1.81270   1.000 26.44409 ? 77  VAL A CB   1 
ATOM   1176 C CG1  . VAL A 1 77  ? -18.89285 -49.48595 1.88205   1.000 27.85334 ? 77  VAL A CG1  1 
ATOM   1177 C CG2  . VAL A 1 77  ? -16.42511 -49.43236 2.31682   1.000 29.00197 ? 77  VAL A CG2  1 
ATOM   1178 H H    . VAL A 1 77  ? -16.08612 -52.31362 1.76929   1.000 35.02040 ? 77  VAL A H    1 
ATOM   1179 H HA   . VAL A 1 77  ? -17.88232 -51.34935 3.54461   1.000 38.77416 ? 77  VAL A HA   1 
ATOM   1180 H HB   . VAL A 1 77  ? -17.42481 -50.48824 0.88184   1.000 31.75568 ? 77  VAL A HB   1 
ATOM   1181 H HG11 . VAL A 1 77  ? -18.69632 -48.53912 1.80596   1.000 33.44678 ? 77  VAL A HG11 1 
ATOM   1182 H HG12 . VAL A 1 77  ? -19.46789 -49.76413 1.15208   1.000 33.44678 ? 77  VAL A HG12 1 
ATOM   1183 H HG13 . VAL A 1 77  ? -19.32537 -49.66681 2.73124   1.000 33.44678 ? 77  VAL A HG13 1 
ATOM   1184 H HG21 . VAL A 1 77  ? -16.58881 -49.18831 3.24123   1.000 34.82514 ? 77  VAL A HG21 1 
ATOM   1185 H HG22 . VAL A 1 77  ? -15.60938 -49.95317 2.25168   1.000 34.82514 ? 77  VAL A HG22 1 
ATOM   1186 H HG23 . VAL A 1 77  ? -16.35183 -48.63334 1.77176   1.000 34.82514 ? 77  VAL A HG23 1 
ATOM   1187 N N    . ILE A 1 78  ? -19.84246 -52.66981 2.94635   1.000 29.88036 ? 78  ILE A N    1 
ATOM   1188 C CA   . ILE A 1 78  ? -20.94250 -53.57349 2.63840   1.000 29.29612 ? 78  ILE A CA   1 
ATOM   1189 C C    . ILE A 1 78  ? -22.28341 -52.84980 2.56182   1.000 31.17590 ? 78  ILE A C    1 
ATOM   1190 O O    . ILE A 1 78  ? -23.32619 -53.49513 2.44814   1.000 30.41804 ? 78  ILE A O    1 
ATOM   1191 C CB   . ILE A 1 78  ? -21.00317 -54.73364 3.65238   1.000 31.89701 ? 78  ILE A CB   1 
ATOM   1192 C CG1  . ILE A 1 78  ? -21.29996 -54.21893 5.06238   1.000 33.97488 ? 78  ILE A CG1  1 
ATOM   1193 C CG2  . ILE A 1 78  ? -19.68396 -55.49596 3.65544   1.000 30.87193 ? 78  ILE A CG2  1 
ATOM   1194 C CD1  . ILE A 1 78  ? -21.44561 -55.32970 6.09169   1.000 31.44546 ? 78  ILE A CD1  1 
ATOM   1195 H H    . ILE A 1 78  ? -19.91324 -52.29463 3.71696   1.000 35.87920 ? 78  ILE A H    1 
ATOM   1196 H HA   . ILE A 1 78  ? -20.78014 -53.95268 1.76047   1.000 35.17812 ? 78  ILE A HA   1 
ATOM   1197 H HB   . ILE A 1 78  ? -21.72252 -55.32557 3.38211   1.000 38.29919 ? 78  ILE A HB   1 
ATOM   1198 H HG12 . ILE A 1 78  ? -20.57201 -53.64391 5.34582   1.000 40.79263 ? 78  ILE A HG12 1 
ATOM   1199 H HG13 . ILE A 1 78  ? -22.13064 -53.71837 5.04492   1.000 40.79263 ? 78  ILE A HG13 1 
ATOM   1200 H HG21 . ILE A 1 78  ? -19.04028 -55.01107 4.19531   1.000 37.06910 ? 78  ILE A HG21 1 
ATOM   1201 H HG22 . ILE A 1 78  ? -19.83042 -56.37910 4.02895   1.000 37.06910 ? 78  ILE A HG22 1 
ATOM   1202 H HG23 . ILE A 1 78  ? -19.36088 -55.57172 2.74397   1.000 37.06910 ? 78  ILE A HG23 1 
ATOM   1203 H HD11 . ILE A 1 78  ? -22.01439 -56.02565 5.72694   1.000 37.75732 ? 78  ILE A HD11 1 
ATOM   1204 H HD12 . ILE A 1 78  ? -20.56815 -55.69110 6.29261   1.000 37.75732 ? 78  ILE A HD12 1 
ATOM   1205 H HD13 . ILE A 1 78  ? -21.84497 -54.96408 6.89650   1.000 37.75732 ? 78  ILE A HD13 1 
ATOM   1206 N N    . GLY A 1 79  ? -22.27778 -51.52580 2.61301   1.000 30.26004 ? 79  GLY A N    1 
ATOM   1207 C CA   . GLY A 1 79  ? -23.50154 -50.76209 2.45967   1.000 31.50473 ? 79  GLY A CA   1 
ATOM   1208 C C    . GLY A 1 79  ? -23.19183 -49.28633 2.57868   1.000 27.70419 ? 79  GLY A C    1 
ATOM   1209 O O    . GLY A 1 79  ? -22.18676 -48.88682 3.17697   1.000 27.51059 ? 79  GLY A O    1 
ATOM   1210 H H    . GLY A 1 79  ? -21.57528 -51.04521 2.73599   1.000 36.33483 ? 79  GLY A H    1 
ATOM   1211 H HA2  . GLY A 1 79  ? -23.89525 -50.93488 1.59016   1.000 37.82846 ? 79  GLY A HA2  1 
ATOM   1212 H HA3  . GLY A 1 79  ? -24.13734 -51.00979 3.14908   1.000 37.82846 ? 79  GLY A HA3  1 
ATOM   1213 N N    . HIS A 1 80  ? -24.06557 -48.47972 1.97728   1.000 30.84731 ? 80  HIS A N    1 
ATOM   1214 C CA   . HIS A 1 80  ? -23.91005 -47.03384 2.05221   1.000 25.24373 ? 80  HIS A CA   1 
ATOM   1215 C C    . HIS A 1 80  ? -25.27620 -46.36461 2.02651   1.000 27.89632 ? 80  HIS A C    1 
ATOM   1216 O O    . HIS A 1 80  ? -26.23407 -46.88366 1.44666   1.000 24.26266 ? 80  HIS A O    1 
ATOM   1217 C CB   . HIS A 1 80  ? -23.02516 -46.49069 0.91890   1.000 27.72543 ? 80  HIS A CB   1 
ATOM   1218 C CG   . HIS A 1 80  ? -23.61947 -46.63408 -0.44751  1.000 29.74657 ? 80  HIS A CG   1 
ATOM   1219 N ND1  . HIS A 1 80  ? -23.54179 -47.80310 -1.17295  1.000 28.82433 ? 80  HIS A ND1  1 
ATOM   1220 C CD2  . HIS A 1 80  ? -24.27927 -45.74826 -1.23116  1.000 29.43791 ? 80  HIS A CD2  1 
ATOM   1221 C CE1  . HIS A 1 80  ? -24.13912 -47.63559 -2.33933  1.000 31.59092 ? 80  HIS A CE1  1 
ATOM   1222 N NE2  . HIS A 1 80  ? -24.59428 -46.39717 -2.40033  1.000 30.37380 ? 80  HIS A NE2  1 
ATOM   1223 H H    . HIS A 1 80  ? -24.74769 -48.74527 1.52585   1.000 37.03955 ? 80  HIS A H    1 
ATOM   1224 H HA   . HIS A 1 80  ? -23.48908 -46.80996 2.89694   1.000 30.31525 ? 80  HIS A HA   1 
ATOM   1225 H HB2  . HIS A 1 80  ? -22.86838 -45.54603 1.07363   1.000 33.29330 ? 80  HIS A HB2  1 
ATOM   1226 H HB3  . HIS A 1 80  ? -22.18309 -46.97213 0.92523   1.000 33.29330 ? 80  HIS A HB3  1 
ATOM   1227 H HD1  . HIS A 1 80  ? -23.16350 -48.52849 -0.90780  1.000 34.61198 ? 80  HIS A HD1  1 
ATOM   1228 H HD2  . HIS A 1 80  ? -24.48128 -44.86590 -1.01776  1.000 35.34828 ? 80  HIS A HD2  1 
ATOM   1229 H HE1  . HIS A 1 80  ? -24.22460 -48.28004 -3.00436  1.000 37.93189 ? 80  HIS A HE1  1 
ATOM   1230 N N    . SER A 1 81  ? -25.34576 -45.19869 2.66716   1.000 27.16188 ? 81  SER A N    1 
ATOM   1231 C CA   . SER A 1 81  ? -26.58142 -44.44510 2.81099   1.000 30.46749 ? 81  SER A CA   1 
ATOM   1232 C C    . SER A 1 81  ? -26.23341 -42.97518 2.98437   1.000 27.95194 ? 81  SER A C    1 
ATOM   1233 O O    . SER A 1 81  ? -25.15049 -42.63474 3.46768   1.000 27.58718 ? 81  SER A O    1 
ATOM   1234 C CB   . SER A 1 81  ? -27.40670 -44.93231 4.00962   1.000 28.32863 ? 81  SER A CB   1 
ATOM   1235 O OG   . SER A 1 81  ? -28.49679 -44.06403 4.26226   1.000 47.45787 ? 81  SER A OG   1 
ATOM   1236 H H    . SER A 1 81  ? -24.67026 -44.81529 3.03634   1.000 32.61703 ? 81  SER A H    1 
ATOM   1237 H HA   . SER A 1 81  ? -27.12017 -44.54729 2.01086   1.000 36.58376 ? 81  SER A HA   1 
ATOM   1238 H HB2  . SER A 1 81  ? -27.74855 -45.81942 3.81707   1.000 34.01714 ? 81  SER A HB2  1 
ATOM   1239 H HB3  . SER A 1 81  ? -26.83703 -44.95938 4.79425   1.000 34.01714 ? 81  SER A HB3  1 
ATOM   1240 H HG   . SER A 1 81  ? -28.82327 -44.22551 5.01918   1.000 56.97222 ? 81  SER A HG   1 
ATOM   1241 N N    . MET A 1 82  ? -27.16274 -42.10845 2.59144   1.000 26.72215 ? 82  MET A N    1 
ATOM   1242 C CA   . MET A 1 82  ? -27.00404 -40.66557 2.72631   1.000 27.89810 ? 82  MET A CA   1 
ATOM   1243 C C    . MET A 1 82  ? -28.04321 -40.15515 3.71210   1.000 27.46046 ? 82  MET A C    1 
ATOM   1244 O O    . MET A 1 82  ? -29.24793 -40.27603 3.46618   1.000 32.12984 ? 82  MET A O    1 
ATOM   1245 C CB   . MET A 1 82  ? -27.14928 -39.95724 1.37697   1.000 27.75982 ? 82  MET A CB   1 
ATOM   1246 C CG   . MET A 1 82  ? -27.09196 -38.43626 1.47062   1.000 24.23824 ? 82  MET A CG   1 
ATOM   1247 S SD   . MET A 1 82  ? -26.80749 -37.62233 -0.11366  1.000 31.37642 ? 82  MET A SD   1 
ATOM   1248 C CE   . MET A 1 82  ? -28.35806 -37.91470 -0.95821  1.000 36.90147 ? 82  MET A CE   1 
ATOM   1249 H H    . MET A 1 82  ? -27.91089 -42.33915 2.23558   1.000 32.08936 ? 82  MET A H    1 
ATOM   1250 H HA   . MET A 1 82  ? -26.11479 -40.47569 3.06404   1.000 33.50050 ? 82  MET A HA   1 
ATOM   1251 H HB2  . MET A 1 82  ? -26.42884 -40.24521 0.79478   1.000 33.33457 ? 82  MET A HB2  1 
ATOM   1252 H HB3  . MET A 1 82  ? -28.00532 -40.19777 0.98937   1.000 33.33457 ? 82  MET A HB3  1 
ATOM   1253 H HG2  . MET A 1 82  ? -27.93623 -38.11286 1.82208   1.000 29.10867 ? 82  MET A HG2  1 
ATOM   1254 H HG3  . MET A 1 82  ? -26.36760 -38.18698 2.06565   1.000 29.10867 ? 82  MET A HG3  1 
ATOM   1255 H HE1  . MET A 1 82  ? -29.08926 -37.67036 -0.36954  1.000 44.30454 ? 82  MET A HE1  1 
ATOM   1256 H HE2  . MET A 1 82  ? -28.38629 -37.37374 -1.76286  1.000 44.30454 ? 82  MET A HE2  1 
ATOM   1257 H HE3  . MET A 1 82  ? -28.41943 -38.85477 -1.18931  1.000 44.30454 ? 82  MET A HE3  1 
ATOM   1258 N N    . GLN A 1 83  ? -27.57339 -39.59506 4.82430   1.000 30.16016 ? 83  GLN A N    1 
ATOM   1259 C CA   . GLN A 1 83  ? -28.42231 -38.96718 5.83143   1.000 28.33805 ? 83  GLN A CA   1 
ATOM   1260 C C    . GLN A 1 83  ? -28.09704 -37.48086 5.84406   1.000 24.48164 ? 83  GLN A C    1 
ATOM   1261 O O    . GLN A 1 83  ? -27.03565 -37.07847 6.33293   1.000 22.42700 ? 83  GLN A O    1 
ATOM   1262 C CB   . GLN A 1 83  ? -28.20164 -39.58544 7.21036   1.000 27.68638 ? 83  GLN A CB   1 
ATOM   1263 C CG   . GLN A 1 83  ? -28.90392 -38.83034 8.33857   1.000 27.06876 ? 83  GLN A CG   1 
ATOM   1264 C CD   . GLN A 1 83  ? -28.74998 -39.49783 9.68971   1.000 31.75774 ? 83  GLN A CD   1 
ATOM   1265 O OE1  . GLN A 1 83  ? -27.73035 -40.12611 9.97558   1.000 29.91120 ? 83  GLN A OE1  1 
ATOM   1266 N NE2  . GLN A 1 83  ? -29.76890 -39.36262 10.53250  1.000 35.30570 ? 83  GLN A NE2  1 
ATOM   1267 H H    . GLN A 1 83  ? -26.73726 -39.56601 5.02341   1.000 36.21497 ? 83  GLN A H    1 
ATOM   1268 H HA   . GLN A 1 83  ? -29.35443 -39.09073 5.59312   1.000 34.02844 ? 83  GLN A HA   1 
ATOM   1269 H HB2  . GLN A 1 83  ? -28.54245 -40.49357 7.20380   1.000 33.24644 ? 83  GLN A HB2  1 
ATOM   1270 H HB3  . GLN A 1 83  ? -27.25088 -39.58928 7.40256   1.000 33.24644 ? 83  GLN A HB3  1 
ATOM   1271 H HG2  . GLN A 1 83  ? -28.52745 -37.93864 8.40203   1.000 32.50529 ? 83  GLN A HG2  1 
ATOM   1272 H HG3  . GLN A 1 83  ? -29.85162 -38.77690 8.13879   1.000 32.50529 ? 83  GLN A HG3  1 
ATOM   1273 H HE21 . GLN A 1 83  ? -30.46490 -38.91546 10.29748  1.000 42.38962 ? 83  GLN A HE21 1 
ATOM   1274 H HE22 . GLN A 1 83  ? -29.73215 -39.72230 11.31281  1.000 42.38962 ? 83  GLN A HE22 1 
ATOM   1275 N N    . ASN A 1 84  ? -29.01241 -36.67134 5.31474   1.000 22.92728 ? 84  ASN A N    1 
ATOM   1276 C CA   . ASN A 1 84  ? -28.78705 -35.23681 5.21163   1.000 22.95118 ? 84  ASN A CA   1 
ATOM   1277 C C    . ASN A 1 84  ? -27.47087 -35.01230 4.47148   1.000 23.74604 ? 84  ASN A C    1 
ATOM   1278 O O    . ASN A 1 84  ? -27.33153 -35.46220 3.32941   1.000 25.18511 ? 84  ASN A O    1 
ATOM   1279 C CB   . ASN A 1 84  ? -28.82036 -34.60141 6.60350   1.000 24.83516 ? 84  ASN A CB   1 
ATOM   1280 C CG   . ASN A 1 84  ? -30.17835 -34.75859 7.27330   1.000 25.91423 ? 84  ASN A CG   1 
ATOM   1281 O OD1  . ASN A 1 84  ? -31.21526 -34.47818 6.67104   1.000 24.04458 ? 84  ASN A OD1  1 
ATOM   1282 N ND2  . ASN A 1 84  ? -30.17815 -35.23505 8.51178   1.000 26.32566 ? 84  ASN A ND2  1 
ATOM   1283 H H    . ASN A 1 84  ? -29.77274 -36.93133 5.00829   1.000 27.53551 ? 84  ASN A H    1 
ATOM   1284 H HA   . ASN A 1 84  ? -29.48589 -34.79090 4.70797   1.000 27.56420 ? 84  ASN A HA   1 
ATOM   1285 H HB2  . ASN A 1 84  ? -28.15479 -35.02899 7.16483   1.000 29.82497 ? 84  ASN A HB2  1 
ATOM   1286 H HB3  . ASN A 1 84  ? -28.62927 -33.65361 6.52560   1.000 29.82497 ? 84  ASN A HB3  1 
ATOM   1287 H HD21 . ASN A 1 84  ? -30.92110 -35.34159 8.93164   1.000 31.61357 ? 84  ASN A HD21 1 
ATOM   1288 H HD22 . ASN A 1 84  ? -29.43508 -35.43731 8.89457   1.000 31.61357 ? 84  ASN A HD22 1 
ATOM   1289 N N    . CYS A 1 85  ? -26.49067 -34.36034 5.09517   1.000 22.65457 ? 85  CYS A N    1 
ATOM   1290 C CA   . CYS A 1 85  ? -25.25950 -33.99821 4.40379   1.000 23.42930 ? 85  CYS A CA   1 
ATOM   1291 C C    . CYS A 1 85  ? -24.08637 -34.92799 4.70896   1.000 25.83110 ? 85  CYS A C    1 
ATOM   1292 O O    . CYS A 1 85  ? -22.95104 -34.59521 4.35445   1.000 24.27645 ? 85  CYS A O    1 
ATOM   1293 C CB   . CYS A 1 85  ? -24.87373 -32.55478 4.73870   1.000 25.86995 ? 85  CYS A CB   1 
ATOM   1294 S SG   . CYS A 1 85  ? -26.06914 -31.32086 4.18756   1.000 26.59566 ? 85  CYS A SG   1 
ATOM   1295 H H    . CYS A 1 85  ? -26.51774 -34.11761 5.91976   1.000 27.20826 ? 85  CYS A H    1 
ATOM   1296 H HA   . CYS A 1 85  ? -25.43049 -34.05842 3.45088   1.000 28.13793 ? 85  CYS A HA   1 
ATOM   1297 H HB2  . CYS A 1 85  ? -24.78868 -32.47234 5.70144   1.000 31.06672 ? 85  CYS A HB2  1 
ATOM   1298 H HB3  . CYS A 1 85  ? -24.02594 -32.35387 4.31234   1.000 31.06672 ? 85  CYS A HB3  1 
ATOM   1299 H HG   . CYS A 1 85  ? -26.16187 -31.37332 2.99230   1.000 31.93756 ? 85  CYS A HG   1 
ATOM   1300 N N    . VAL A 1 86  ? -24.31869 -36.08615 5.33297   1.000 22.62466 ? 86  VAL A N    1 
ATOM   1301 C CA   . VAL A 1 86  ? -23.24292 -37.04448 5.55883   1.000 21.10092 ? 86  VAL A CA   1 
ATOM   1302 C C    . VAL A 1 86  ? -23.59635 -38.37087 4.90253   1.000 24.55691 ? 86  VAL A C    1 
ATOM   1303 O O    . VAL A 1 86  ? -24.76209 -38.68514 4.64709   1.000 22.20412 ? 86  VAL A O    1 
ATOM   1304 C CB   . VAL A 1 86  ? -22.92482 -37.27098 7.05471   1.000 24.60232 ? 86  VAL A CB   1 
ATOM   1305 C CG1  . VAL A 1 86  ? -22.53180 -35.95954 7.72964   1.000 25.29294 ? 86  VAL A CG1  1 
ATOM   1306 C CG2  . VAL A 1 86  ? -24.09785 -37.93363 7.77258   1.000 27.32389 ? 86  VAL A CG2  1 
ATOM   1307 H H    . VAL A 1 86  ? -25.08648 -36.33379 5.63091   1.000 27.17237 ? 86  VAL A H    1 
ATOM   1308 H HA   . VAL A 1 86  ? -22.44760 -36.68996 5.13141   1.000 25.34388 ? 86  VAL A HA   1 
ATOM   1309 H HB   . VAL A 1 86  ? -22.16812 -37.87438 7.11979   1.000 29.54556 ? 86  VAL A HB   1 
ATOM   1310 H HG11 . VAL A 1 86  ? -22.69039 -35.22735 7.11348   1.000 30.37431 ? 86  VAL A HG11 1 
ATOM   1311 H HG12 . VAL A 1 86  ? -23.06938 -35.84198 8.52844   1.000 30.37431 ? 86  VAL A HG12 1 
ATOM   1312 H HG13 . VAL A 1 86  ? -21.59170 -35.99531 7.96591   1.000 30.37431 ? 86  VAL A HG13 1 
ATOM   1313 H HG21 . VAL A 1 86  ? -24.88254 -37.37072 7.68153   1.000 32.81145 ? 86  VAL A HG21 1 
ATOM   1314 H HG22 . VAL A 1 86  ? -24.26452 -38.80086 7.37128   1.000 32.81145 ? 86  VAL A HG22 1 
ATOM   1315 H HG23 . VAL A 1 86  ? -23.87448 -38.04056 8.71043   1.000 32.81145 ? 86  VAL A HG23 1 
ATOM   1316 N N    . LEU A 1 87  ? -22.55654 -39.15108 4.63126   1.000 23.88594 ? 87  LEU A N    1 
ATOM   1317 C CA   . LEU A 1 87  ? -22.69667 -40.52970 4.19240   1.000 24.72651 ? 87  LEU A CA   1 
ATOM   1318 C C    . LEU A 1 87  ? -22.41915 -41.45665 5.36608   1.000 25.48640 ? 87  LEU A C    1 
ATOM   1319 O O    . LEU A 1 87  ? -21.54196 -41.18483 6.19159   1.000 24.99246 ? 87  LEU A O    1 
ATOM   1320 C CB   . LEU A 1 87  ? -21.73742 -40.85044 3.04450   1.000 27.65111 ? 87  LEU A CB   1 
ATOM   1321 C CG   . LEU A 1 87  ? -22.02309 -40.17578 1.70460   1.000 25.85096 ? 87  LEU A CG   1 
ATOM   1322 C CD1  . LEU A 1 87  ? -20.96428 -40.57892 0.67934   1.000 29.69024 ? 87  LEU A CD1  1 
ATOM   1323 C CD2  . LEU A 1 87  ? -23.41868 -40.50822 1.20965   1.000 26.84413 ? 87  LEU A CD2  1 
ATOM   1324 H H    . LEU A 1 87  ? -21.73800 -38.89544 4.69641   1.000 28.68590 ? 87  LEU A H    1 
ATOM   1325 H HA   . LEU A 1 87  ? -23.60022 -40.67890 3.87264   1.000 29.69459 ? 87  LEU A HA   1 
ATOM   1326 H HB2  . LEU A 1 87  ? -20.84574 -40.58042 3.31451   1.000 33.20411 ? 87  LEU A HB2  1 
ATOM   1327 H HB3  . LEU A 1 87  ? -21.76209 -41.80802 2.89177   1.000 33.20411 ? 87  LEU A HB3  1 
ATOM   1328 H HG   . LEU A 1 87  ? -21.98407 -39.21338 1.81936   1.000 31.04393 ? 87  LEU A HG   1 
ATOM   1329 H HD11 . LEU A 1 87  ? -20.73807 -41.51313 0.80963   1.000 35.65107 ? 87  LEU A HD11 1 
ATOM   1330 H HD12 . LEU A 1 87  ? -21.32177 -40.44643 -0.21260  1.000 35.65107 ? 87  LEU A HD12 1 
ATOM   1331 H HD13 . LEU A 1 87  ? -20.17650 -40.02716 0.80528   1.000 35.65107 ? 87  LEU A HD13 1 
ATOM   1332 H HD21 . LEU A 1 87  ? -24.06828 -40.04816 1.76396   1.000 32.23573 ? 87  LEU A HD21 1 
ATOM   1333 H HD22 . LEU A 1 87  ? -23.50471 -40.21710 0.28837   1.000 32.23573 ? 87  LEU A HD22 1 
ATOM   1334 H HD23 . LEU A 1 87  ? -23.55428 -41.46695 1.26763   1.000 32.23573 ? 87  LEU A HD23 1 
ATOM   1335 N N    . LYS A 1 88  ? -23.17940 -42.54302 5.44313   1.000 24.95781 ? 88  LYS A N    1 
ATOM   1336 C CA   . LYS A 1 88  ? -22.93597 -43.61681 6.39905   1.000 23.01917 ? 88  LYS A CA   1 
ATOM   1337 C C    . LYS A 1 88  ? -22.48149 -44.83820 5.60964   1.000 28.37538 ? 88  LYS A C    1 
ATOM   1338 O O    . LYS A 1 88  ? -23.26005 -45.41061 4.84035   1.000 27.92953 ? 88  LYS A O    1 
ATOM   1339 C CB   . LYS A 1 88  ? -24.18862 -43.91040 7.22187   1.000 26.04528 ? 88  LYS A CB   1 
ATOM   1340 C CG   . LYS A 1 88  ? -24.63990 -42.72189 8.05762   1.000 28.80165 ? 88  LYS A CG   1 
ATOM   1341 C CD   . LYS A 1 88  ? -25.67335 -43.10702 9.10864   1.000 27.99537 ? 88  LYS A CD   1 
ATOM   1342 C CE   . LYS A 1 88  ? -27.05628 -43.27462 8.51069   1.000 33.57843 ? 88  LYS A CE   1 
ATOM   1343 N NZ   . LYS A 1 88  ? -28.11247 -43.13038 9.54775   1.000 39.99543 ? 88  LYS A NZ   1 
ATOM   1344 H H    . LYS A 1 88  ? -23.86089 -42.68431 4.93794   1.000 29.97215 ? 88  LYS A H    1 
ATOM   1345 H HA   . LYS A 1 88  ? -22.23048 -43.36318 7.01457   1.000 27.64578 ? 88  LYS A HA   1 
ATOM   1346 H HB2  . LYS A 1 88  ? -24.91241 -44.14626 6.62070   1.000 31.27711 ? 88  LYS A HB2  1 
ATOM   1347 H HB3  . LYS A 1 88  ? -24.00417 -44.64784 7.82442   1.000 31.27711 ? 88  LYS A HB3  1 
ATOM   1348 H HG2  . LYS A 1 88  ? -23.87180 -42.34549 8.51506   1.000 34.58476 ? 88  LYS A HG2  1 
ATOM   1349 H HG3  . LYS A 1 88  ? -25.03768 -42.05652 7.47456   1.000 34.58476 ? 88  LYS A HG3  1 
ATOM   1350 H HD2  . LYS A 1 88  ? -25.41582 -43.94862 9.51642   1.000 33.61722 ? 88  LYS A HD2  1 
ATOM   1351 H HD3  . LYS A 1 88  ? -25.71746 -42.41133 9.78315   1.000 33.61722 ? 88  LYS A HD3  1 
ATOM   1352 H HE2  . LYS A 1 88  ? -27.19842 -42.59589 7.83244   1.000 40.31689 ? 88  LYS A HE2  1 
ATOM   1353 H HE3  . LYS A 1 88  ? -27.13221 -44.15793 8.11713   1.000 40.31689 ? 88  LYS A HE3  1 
ATOM   1354 H HZ1  . LYS A 1 88  ? -28.14612 -42.28794 9.83283   1.000 48.01729 ? 88  LYS A HZ1  1 
ATOM   1355 H HZ2  . LYS A 1 88  ? -28.90469 -43.35230 9.20831   1.000 48.01729 ? 88  LYS A HZ2  1 
ATOM   1356 H HZ3  . LYS A 1 88  ? -27.93511 -43.66232 10.23890  1.000 48.01729 ? 88  LYS A HZ3  1 
ATOM   1357 N N    . LEU A 1 89  ? -21.21902 -45.22265 5.78325   1.000 25.55113 ? 89  LEU A N    1 
ATOM   1358 C CA   . LEU A 1 89  ? -20.64185 -46.36154 5.07944   1.000 25.84529 ? 89  LEU A CA   1 
ATOM   1359 C C    . LEU A 1 89  ? -20.61100 -47.54118 6.04495   1.000 24.60330 ? 89  LEU A C    1 
ATOM   1360 O O    . LEU A 1 89  ? -19.88991 -47.51375 7.04770   1.000 24.65690 ? 89  LEU A O    1 
ATOM   1361 C CB   . LEU A 1 89  ? -19.24420 -46.03293 4.55613   1.000 27.66824 ? 89  LEU A CB   1 
ATOM   1362 C CG   . LEU A 1 89  ? -19.12225 -44.77124 3.70151   1.000 22.50569 ? 89  LEU A CG   1 
ATOM   1363 C CD1  . LEU A 1 89  ? -17.65986 -44.56603 3.27977   1.000 23.15147 ? 89  LEU A CD1  1 
ATOM   1364 C CD2  . LEU A 1 89  ? -20.04765 -44.83718 2.49032   1.000 26.65007 ? 89  LEU A CD2  1 
ATOM   1365 H H    . LEU A 1 89  ? -20.66772 -44.83067 6.31431   1.000 30.68413 ? 89  LEU A H    1 
ATOM   1366 H HA   . LEU A 1 89  ? -21.19715 -46.59321 4.31860   1.000 31.03713 ? 89  LEU A HA   1 
ATOM   1367 H HB2  . LEU A 1 89  ? -18.65552 -45.92007 5.31876   1.000 33.22467 ? 89  LEU A HB2  1 
ATOM   1368 H HB3  . LEU A 1 89  ? -18.94323 -46.77741 4.01201   1.000 33.22467 ? 89  LEU A HB3  1 
ATOM   1369 H HG   . LEU A 1 89  ? -19.39690 -44.00113 4.22343   1.000 27.02960 ? 89  LEU A HG   1 
ATOM   1370 H HD11 . LEU A 1 89  ? -17.55262 -44.85622 2.36042   1.000 27.80454 ? 89  LEU A HD11 1 
ATOM   1371 H HD12 . LEU A 1 89  ? -17.43780 -43.62500 3.35764   1.000 27.80454 ? 89  LEU A HD12 1 
ATOM   1372 H HD13 . LEU A 1 89  ? -17.08701 -45.09027 3.86107   1.000 27.80454 ? 89  LEU A HD13 1 
ATOM   1373 H HD21 . LEU A 1 89  ? -20.30047 -45.76085 2.33597   1.000 32.00286 ? 89  LEU A HD21 1 
ATOM   1374 H HD22 . LEU A 1 89  ? -20.83782 -44.30308 2.66716   1.000 32.00286 ? 89  LEU A HD22 1 
ATOM   1375 H HD23 . LEU A 1 89  ? -19.57931 -44.48856 1.71571   1.000 32.00286 ? 89  LEU A HD23 1 
ATOM   1376 N N    . LYS A 1 90  ? -21.40707 -48.56538 5.75246   1.000 25.80344 ? 90  LYS A N    1 
ATOM   1377 C CA   . LYS A 1 90  ? -21.39420 -49.78916 6.54082   1.000 28.01529 ? 90  LYS A CA   1 
ATOM   1378 C C    . LYS A 1 90  ? -20.17127 -50.61737 6.16898   1.000 27.75559 ? 90  LYS A C    1 
ATOM   1379 O O    . LYS A 1 90  ? -19.92017 -50.86615 4.98641   1.000 29.53572 ? 90  LYS A O    1 
ATOM   1380 C CB   . LYS A 1 90  ? -22.67101 -50.59179 6.29371   1.000 28.44875 ? 90  LYS A CB   1 
ATOM   1381 C CG   . LYS A 1 90  ? -22.79076 -51.87434 7.10975   1.000 32.95611 ? 90  LYS A CG   1 
ATOM   1382 C CD   . LYS A 1 90  ? -23.28769 -51.60522 8.51516   1.000 36.52971 ? 90  LYS A CD   1 
ATOM   1383 C CE   . LYS A 1 90  ? -24.10020 -52.78218 9.03391   1.000 43.95337 ? 90  LYS A CE   1 
ATOM   1384 N NZ   . LYS A 1 90  ? -24.76861 -52.48876 10.33345  1.000 64.26245 ? 90  LYS A NZ   1 
ATOM   1385 H H    . LYS A 1 90  ? -21.96593 -48.57493 5.09887   1.000 30.98690 ? 90  LYS A H    1 
ATOM   1386 H HA   . LYS A 1 90  ? -21.35120 -49.57314 7.48549   1.000 33.64113 ? 90  LYS A HA   1 
ATOM   1387 H HB2  . LYS A 1 90  ? -23.43274 -50.03350 6.51503   1.000 34.16128 ? 90  LYS A HB2  1 
ATOM   1388 H HB3  . LYS A 1 90  ? -22.70211 -50.83900 5.35625   1.000 34.16128 ? 90  LYS A HB3  1 
ATOM   1389 H HG2  . LYS A 1 90  ? -23.41894 -52.47231 6.67535   1.000 39.57011 ? 90  LYS A HG2  1 
ATOM   1390 H HG3  . LYS A 1 90  ? -21.91961 -52.29642 7.17181   1.000 39.57011 ? 90  LYS A HG3  1 
ATOM   1391 H HD2  . LYS A 1 90  ? -22.53068 -51.46912 9.10619   1.000 43.85842 ? 90  LYS A HD2  1 
ATOM   1392 H HD3  . LYS A 1 90  ? -23.85331 -50.81720 8.51369   1.000 43.85842 ? 90  LYS A HD3  1 
ATOM   1393 H HE2  . LYS A 1 90  ? -24.78734 -53.00302 8.38587   1.000 52.76682 ? 90  LYS A HE2  1 
ATOM   1394 H HE3  . LYS A 1 90  ? -23.51065 -53.54138 9.16409   1.000 52.76682 ? 90  LYS A HE3  1 
ATOM   1395 H HZ1  . LYS A 1 90  ? -24.68098 -53.18233 10.88425  1.000 77.13771 ? 90  LYS A HZ1  1 
ATOM   1396 H HZ2  . LYS A 1 90  ? -24.39960 -51.77202 10.71055  1.000 77.13771 ? 90  LYS A HZ2  1 
ATOM   1397 H HZ3  . LYS A 1 90  ? -25.63477 -52.33217 10.20172  1.000 77.13771 ? 90  LYS A HZ3  1 
ATOM   1398 N N    . VAL A 1 91  ? -19.41344 -51.04312 7.17917   1.000 26.92997 ? 91  VAL A N    1 
ATOM   1399 C CA   . VAL A 1 91  ? -18.23336 -51.87540 6.98842   1.000 27.99424 ? 91  VAL A CA   1 
ATOM   1400 C C    . VAL A 1 91  ? -18.43351 -53.17195 7.76593   1.000 30.90999 ? 91  VAL A C    1 
ATOM   1401 O O    . VAL A 1 91  ? -19.26869 -53.26034 8.66914   1.000 29.96619 ? 91  VAL A O    1 
ATOM   1402 C CB   . VAL A 1 91  ? -16.93696 -51.15814 7.42419   1.000 25.39598 ? 91  VAL A CB   1 
ATOM   1403 C CG1  . VAL A 1 91  ? -16.67044 -49.95837 6.52332   1.000 31.63709 ? 91  VAL A CG1  1 
ATOM   1404 C CG2  . VAL A 1 91  ? -17.01406 -50.72420 8.88070   1.000 31.03450 ? 91  VAL A CG2  1 
ATOM   1405 H H    . VAL A 1 91  ? -19.56898 -50.85664 8.00418   1.000 32.33874 ? 91  VAL A H    1 
ATOM   1406 H HA   . VAL A 1 91  ? -18.14233 -52.09896 6.04893   1.000 33.61587 ? 91  VAL A HA   1 
ATOM   1407 H HB   . VAL A 1 91  ? -16.19666 -51.77926 7.34013   1.000 30.49795 ? 91  VAL A HB   1 
ATOM   1408 H HG11 . VAL A 1 91  ? -17.20539 -50.04270 5.71857   1.000 37.98729 ? 91  VAL A HG11 1 
ATOM   1409 H HG12 . VAL A 1 91  ? -16.91202 -49.14746 6.99763   1.000 37.98729 ? 91  VAL A HG12 1 
ATOM   1410 H HG13 . VAL A 1 91  ? -15.72822 -49.93902 6.29366   1.000 37.98729 ? 91  VAL A HG13 1 
ATOM   1411 H HG21 . VAL A 1 91  ? -17.89016 -50.34430 9.05108   1.000 37.26418 ? 91  VAL A HG21 1 
ATOM   1412 H HG22 . VAL A 1 91  ? -16.87285 -51.49780 9.44860   1.000 37.26418 ? 91  VAL A HG22 1 
ATOM   1413 H HG23 . VAL A 1 91  ? -16.32718 -50.06035 9.04923   1.000 37.26418 ? 91  VAL A HG23 1 
ATOM   1414 N N    . ASP A 1 92  ? -17.66096 -54.19245 7.39591   1.000 30.95762 ? 92  ASP A N    1 
ATOM   1415 C CA   . ASP A 1 92  ? -17.82551 -55.52594 7.96061   1.000 32.43657 ? 92  ASP A CA   1 
ATOM   1416 C C    . ASP A 1 92  ? -17.03862 -55.73152 9.25178   1.000 33.61380 ? 92  ASP A C    1 
ATOM   1417 O O    . ASP A 1 92  ? -17.02833 -56.84669 9.78269   1.000 33.20263 ? 92  ASP A O    1 
ATOM   1418 C CB   . ASP A 1 92  ? -17.42424 -56.58637 6.92791   1.000 33.22729 ? 92  ASP A CB   1 
ATOM   1419 C CG   . ASP A 1 92  ? -15.92235 -56.64760 6.69199   1.000 36.21155 ? 92  ASP A CG   1 
ATOM   1420 O OD1  . ASP A 1 92  ? -15.19138 -55.76377 7.18675   1.000 34.74530 ? 92  ASP A OD1  1 
ATOM   1421 O OD2  . ASP A 1 92  ? -15.47235 -57.58975 6.00421   1.000 39.17158 ? 92  ASP A OD2  1 
ATOM   1422 H H    . ASP A 1 92  ? -17.03004 -54.13427 6.81439   1.000 37.17192 ? 92  ASP A H    1 
ATOM   1423 H HA   . ASP A 1 92  ? -18.76379 -55.65355 8.17096   1.000 38.94667 ? 92  ASP A HA   1 
ATOM   1424 H HB2  . ASP A 1 92  ? -17.71330 -57.45743 7.24192   1.000 39.89553 ? 92  ASP A HB2  1 
ATOM   1425 H HB3  . ASP A 1 92  ? -17.85159 -56.38008 6.08191   1.000 39.89553 ? 92  ASP A HB3  1 
ATOM   1426 N N    . THR A 1 93  ? -16.39214 -54.68852 9.77063   1.000 29.86510 ? 93  THR A N    1 
ATOM   1427 C CA   . THR A 1 93  ? -15.60574 -54.77519 10.99394  1.000 26.28636 ? 93  THR A CA   1 
ATOM   1428 C C    . THR A 1 93  ? -16.00537 -53.63962 11.92167  1.000 29.61938 ? 93  THR A C    1 
ATOM   1429 O O    . THR A 1 93  ? -16.04776 -52.47885 11.50285  1.000 29.03712 ? 93  THR A O    1 
ATOM   1430 C CB   . THR A 1 93  ? -14.09983 -54.70103 10.70240  1.000 32.34718 ? 93  THR A CB   1 
ATOM   1431 O OG1  . THR A 1 93  ? -13.73486 -55.72420 9.76672   1.000 38.75211 ? 93  THR A OG1  1 
ATOM   1432 C CG2  . THR A 1 93  ? -13.30300 -54.88060 11.97917  1.000 31.80845 ? 93  THR A CG2  1 
ATOM   1433 H H    . THR A 1 93  ? -16.39584 -53.90251 9.42167   1.000 35.86089 ? 93  THR A H    1 
ATOM   1434 H HA   . THR A 1 93  ? -15.79171 -55.61978 11.43324  1.000 31.56641 ? 93  THR A HA   1 
ATOM   1435 H HB   . THR A 1 93  ? -13.88737 -53.83244 10.32648  1.000 38.83940 ? 93  THR A HB   1 
ATOM   1436 H HG1  . THR A 1 93  ? -13.86608 -55.45568 8.98169   1.000 46.52531 ? 93  THR A HG1  1 
ATOM   1437 H HG21 . THR A 1 93  ? -12.35581 -54.92718 11.77532  1.000 38.19292 ? 93  THR A HG21 1 
ATOM   1438 H HG22 . THR A 1 93  ? -13.46008 -54.13246 12.57626  1.000 38.19292 ? 93  THR A HG22 1 
ATOM   1439 H HG23 . THR A 1 93  ? -13.56988 -55.70006 12.42432  1.000 38.19292 ? 93  THR A HG23 1 
ATOM   1440 N N    . ALA A 1 94  ? -16.29883 -53.97470 13.17377  1.000 27.56975 ? 94  ALA A N    1 
ATOM   1441 C CA   . ALA A 1 94  ? -16.53496 -52.96222 14.19001  1.000 27.79533 ? 94  ALA A CA   1 
ATOM   1442 C C    . ALA A 1 94  ? -15.20221 -52.42088 14.68685  1.000 29.22194 ? 94  ALA A C    1 
ATOM   1443 O O    . ALA A 1 94  ? -14.26720 -53.18231 14.95207  1.000 24.61858 ? 94  ALA A O    1 
ATOM   1444 C CB   . ALA A 1 94  ? -17.34069 -53.54307 15.35137  1.000 31.12331 ? 94  ALA A CB   1 
ATOM   1445 H H    . ALA A 1 94  ? -16.36672 -54.78339 13.45842  1.000 33.10648 ? 94  ALA A H    1 
ATOM   1446 H HA   . ALA A 1 94  ? -17.04686 -52.23112 13.81007  1.000 33.37717 ? 94  ALA A HA   1 
ATOM   1447 H HB1  . ALA A 1 94  ? -17.46786 -52.85478 16.02293  1.000 37.37074 ? 94  ALA A HB1  1 
ATOM   1448 H HB2  . ALA A 1 94  ? -18.20090 -53.84432 15.01945  1.000 37.37074 ? 94  ALA A HB2  1 
ATOM   1449 H HB3  . ALA A 1 94  ? -16.85280 -54.29020 15.73173  1.000 37.37074 ? 94  ALA A HB3  1 
ATOM   1450 N N    . ASN A 1 95  ? -15.11147 -51.10304 14.79771  1.000 28.07324 ? 95  ASN A N    1 
ATOM   1451 C CA   . ASN A 1 95  ? -13.87625 -50.47984 15.24961  1.000 27.93039 ? 95  ASN A CA   1 
ATOM   1452 C C    . ASN A 1 95  ? -13.55006 -50.98022 16.65202  1.000 25.61000 ? 95  ASN A C    1 
ATOM   1453 O O    . ASN A 1 95  ? -14.28017 -50.66336 17.60062  1.000 24.82127 ? 95  ASN A O    1 
ATOM   1454 C CB   . ASN A 1 95  ? -14.00767 -48.95537 15.23370  1.000 25.62378 ? 95  ASN A CB   1 
ATOM   1455 C CG   . ASN A 1 95  ? -12.69925 -48.25114 15.53558  1.000 28.63344 ? 95  ASN A CG   1 
ATOM   1456 O OD1  . ASN A 1 95  ? -11.68354 -48.89034 15.80804  1.000 26.47386 ? 95  ASN A OD1  1 
ATOM   1457 N ND2  . ASN A 1 95  ? -12.71609 -46.92233 15.47891  1.000 27.14820 ? 95  ASN A ND2  1 
ATOM   1458 H H    . ASN A 1 95  ? -15.74668 -50.55167 14.61855  1.000 33.71066 ? 95  ASN A H    1 
ATOM   1459 H HA   . ASN A 1 95  ? -13.14627 -50.71946 14.65749  1.000 33.53924 ? 95  ASN A HA   1 
ATOM   1460 H HB2  . ASN A 1 95  ? -14.30459 -48.67278 14.35456  1.000 30.77132 ? 95  ASN A HB2  1 
ATOM   1461 H HB3  . ASN A 1 95  ? -14.65469 -48.68679 15.90461  1.000 30.77132 ? 95  ASN A HB3  1 
ATOM   1462 H HD21 . ASN A 1 95  ? -11.99935 -46.47587 15.64189  1.000 32.60062 ? 95  ASN A HD21 1 
ATOM   1463 H HD22 . ASN A 1 95  ? -13.44371 -46.50963 15.27929  1.000 32.60062 ? 95  ASN A HD22 1 
ATOM   1464 N N    . PRO A 1 96  ? -12.48324 -51.76771 16.83139  1.000 30.66953 ? 96  PRO A N    1 
ATOM   1465 C CA   . PRO A 1 96  ? -12.16810 -52.27259 18.17733  1.000 29.55650 ? 96  PRO A CA   1 
ATOM   1466 C C    . PRO A 1 96  ? -11.79824 -51.17305 19.15484  1.000 33.82173 ? 96  PRO A C    1 
ATOM   1467 O O    . PRO A 1 96  ? -11.74517 -51.43495 20.36346  1.000 31.95676 ? 96  PRO A O    1 
ATOM   1468 C CB   . PRO A 1 96  ? -10.99299 -53.22603 17.92909  1.000 32.75149 ? 96  PRO A CB   1 
ATOM   1469 C CG   . PRO A 1 96  ? -10.33863 -52.70331 16.69792  1.000 32.12412 ? 96  PRO A CG   1 
ATOM   1470 C CD   . PRO A 1 96  ? -11.43807 -52.12057 15.85143  1.000 29.03957 ? 96  PRO A CD   1 
ATOM   1471 H HA   . PRO A 1 96  ? -12.91298 -52.78149 18.53380  1.000 35.49057 ? 96  PRO A HA   1 
ATOM   1472 H HB2  . PRO A 1 96  ? -10.38360 -53.20487 18.68348  1.000 39.32457 ? 96  PRO A HB2  1 
ATOM   1473 H HB3  . PRO A 1 96  ? -11.32121 -54.12860 17.79296  1.000 39.32457 ? 96  PRO A HB3  1 
ATOM   1474 H HG2  . PRO A 1 96  ? -9.69284  -52.02033 16.93746  1.000 38.57172 ? 96  PRO A HG2  1 
ATOM   1475 H HG3  . PRO A 1 96  ? -9.89597  -53.42938 16.23126  1.000 38.57172 ? 96  PRO A HG3  1 
ATOM   1476 H HD2  . PRO A 1 96  ? -11.12777 -51.33131 15.38059  1.000 34.87026 ? 96  PRO A HD2  1 
ATOM   1477 H HD3  . PRO A 1 96  ? -11.76837 -52.77648 15.21773  1.000 34.87026 ? 96  PRO A HD3  1 
ATOM   1478 N N    . LYS A 1 97  ? -11.55039 -49.95718 18.67121  1.000 31.79082 ? 97  LYS A N    1 
ATOM   1479 C CA   . LYS A 1 97  ? -11.20910 -48.81855 19.50908  1.000 31.14001 ? 97  LYS A CA   1 
ATOM   1480 C C    . LYS A 1 97  ? -12.39827 -47.90566 19.77833  1.000 31.42912 ? 97  LYS A C    1 
ATOM   1481 O O    . LYS A 1 97  ? -12.20739 -46.80020 20.29379  1.000 30.54664 ? 97  LYS A O    1 
ATOM   1482 C CB   . LYS A 1 97  ? -10.09107 -48.00462 18.85702  1.000 34.55381 ? 97  LYS A CB   1 
ATOM   1483 C CG   . LYS A 1 97  ? -8.75685  -48.72083 18.73780  1.000 40.59710 ? 97  LYS A CG   1 
ATOM   1484 C CD   . LYS A 1 97  ? -7.77064  -47.87012 17.95047  1.000 46.17257 ? 97  LYS A CD   1 
ATOM   1485 C CE   . LYS A 1 97  ? -6.37982  -48.47507 17.92861  1.000 44.39278 ? 97  LYS A CE   1 
ATOM   1486 N NZ   . LYS A 1 97  ? -5.48743  -47.73812 16.99015  1.000 48.59275 ? 97  LYS A NZ   1 
ATOM   1487 H H    . LYS A 1 97  ? -11.57549 -49.76450 17.83345  1.000 38.17176 ? 97  LYS A H    1 
ATOM   1488 H HA   . LYS A 1 97  ? -10.88982 -49.15719 20.36013  1.000 37.39078 ? 97  LYS A HA   1 
ATOM   1489 H HB2  . LYS A 1 97  ? -10.37139 -47.76205 17.96065  1.000 41.48735 ? 97  LYS A HB2  1 
ATOM   1490 H HB3  . LYS A 1 97  ? -9.94506  -47.20523 19.38669  1.000 41.48735 ? 97  LYS A HB3  1 
ATOM   1491 H HG2  . LYS A 1 97  ? -8.39198  -48.87984 19.62238  1.000 48.73930 ? 97  LYS A HG2  1 
ATOM   1492 H HG3  . LYS A 1 97  ? -8.87949  -49.56342 18.27313  1.000 48.73930 ? 97  LYS A HG3  1 
ATOM   1493 H HD2  . LYS A 1 97  ? -8.07937  -47.79040 17.03437  1.000 55.42986 ? 97  LYS A HD2  1 
ATOM   1494 H HD3  . LYS A 1 97  ? -7.71127  -46.99196 18.35816  1.000 55.42986 ? 97  LYS A HD3  1 
ATOM   1495 H HE2  . LYS A 1 97  ? -5.99436  -48.42944 18.81756  1.000 53.29411 ? 97  LYS A HE2  1 
ATOM   1496 H HE3  . LYS A 1 97  ? -6.43455  -49.39882 17.63775  1.000 53.29411 ? 97  LYS A HE3  1 
ATOM   1497 H HZ1  . LYS A 1 97  ? -5.82990  -47.75386 16.16883  1.000 58.33408 ? 97  LYS A HZ1  1 
ATOM   1498 H HZ2  . LYS A 1 97  ? -5.40312  -46.89162 17.25176  1.000 58.33408 ? 97  LYS A HZ2  1 
ATOM   1499 H HZ3  . LYS A 1 97  ? -4.68235  -48.11721 16.97471  1.000 58.33408 ? 97  LYS A HZ3  1 
ATOM   1500 N N    . THR A 1 98  ? -13.60980 -48.32837 19.43799  1.000 29.23672 ? 98  THR A N    1 
ATOM   1501 C CA   . THR A 1 98  ? -14.77238 -47.46821 19.60565  1.000 27.04613 ? 98  THR A CA   1 
ATOM   1502 C C    . THR A 1 98  ? -14.92913 -47.07756 21.07160  1.000 31.64720 ? 98  THR A C    1 
ATOM   1503 O O    . THR A 1 98  ? -15.06593 -47.96466 21.92843  1.000 27.83708 ? 98  THR A O    1 
ATOM   1504 C CB   . THR A 1 98  ? -16.04334 -48.16327 19.12459  1.000 28.75646 ? 98  THR A CB   1 
ATOM   1505 O OG1  . THR A 1 98  ? -15.85853 -48.63469 17.78616  1.000 28.29445 ? 98  THR A OG1  1 
ATOM   1506 C CG2  . THR A 1 98  ? -17.22768 -47.20193 19.15739  1.000 27.72593 ? 98  THR A CG2  1 
ATOM   1507 H H    . THR A 1 98  ? -13.78368 -49.10409 19.10994  1.000 35.10684 ? 98  THR A H    1 
ATOM   1508 H HA   . THR A 1 98  ? -14.64352 -46.66845 19.07210  1.000 32.47813 ? 98  THR A HA   1 
ATOM   1509 H HB   . THR A 1 98  ? -16.23891 -48.91252 19.70879  1.000 34.53053 ? 98  THR A HB   1 
ATOM   1510 H HG1  . THR A 1 98  ? -16.55150 -49.02939 17.52233  1.000 33.97612 ? 98  THR A HG1  1 
ATOM   1511 H HG21 . THR A 1 98  ? -18.03143 -47.65539 18.85864  1.000 33.29389 ? 98  THR A HG21 1 
ATOM   1512 H HG22 . THR A 1 98  ? -17.36666 -46.87744 20.06088  1.000 33.29389 ? 98  THR A HG22 1 
ATOM   1513 H HG23 . THR A 1 98  ? -17.05752 -46.44585 18.57405  1.000 33.29389 ? 98  THR A HG23 1 
ATOM   1514 N N    . PRO A 1 99  ? -14.91833 -45.79129 21.40616  1.000 30.44520 ? 99  PRO A N    1 
ATOM   1515 C CA   . PRO A 1 99  ? -15.21054 -45.37777 22.78067  1.000 29.25176 ? 99  PRO A CA   1 
ATOM   1516 C C    . PRO A 1 99  ? -16.71182 -45.35341 23.03614  1.000 28.88175 ? 99  PRO A C    1 
ATOM   1517 O O    . PRO A 1 99  ? -17.52865 -45.41733 22.11716  1.000 26.94380 ? 99  PRO A O    1 
ATOM   1518 C CB   . PRO A 1 99  ? -14.62045 -43.96597 22.84689  1.000 30.84346 ? 99  PRO A CB   1 
ATOM   1519 C CG   . PRO A 1 99  ? -14.82854 -43.44298 21.46361  1.000 28.61622 ? 99  PRO A CG   1 
ATOM   1520 C CD   . PRO A 1 99  ? -14.59335 -44.63364 20.55108  1.000 26.06387 ? 99  PRO A CD   1 
ATOM   1521 H HA   . PRO A 1 99  ? -14.77228 -45.95362 23.42659  1.000 35.12489 ? 99  PRO A HA   1 
ATOM   1522 H HB2  . PRO A 1 99  ? -15.09636 -43.43193 23.50203  1.000 37.03493 ? 99  PRO A HB2  1 
ATOM   1523 H HB3  . PRO A 1 99  ? -13.67774 -44.00471 23.07207  1.000 37.03493 ? 99  PRO A HB3  1 
ATOM   1524 H HG2  . PRO A 1 99  ? -15.73415 -43.10835 21.36984  1.000 34.36224 ? 99  PRO A HG2  1 
ATOM   1525 H HG3  . PRO A 1 99  ? -14.19228 -42.73439 21.27928  1.000 34.36224 ? 99  PRO A HG3  1 
ATOM   1526 H HD2  . PRO A 1 99  ? -15.18139 -44.59861 19.78044  1.000 31.29942 ? 99  PRO A HD2  1 
ATOM   1527 H HD3  . PRO A 1 99  ? -13.66831 -44.66823 20.26124  1.000 31.29942 ? 99  PRO A HD3  1 
ATOM   1528 N N    . LYS A 1 100 ? -17.06979 -45.26370 24.31585  1.000 32.22569 ? 100 LYS A N    1 
ATOM   1529 C CA   . LYS A 1 100 ? -18.41840 -44.83292 24.65423  1.000 36.07181 ? 100 LYS A CA   1 
ATOM   1530 C C    . LYS A 1 100 ? -18.64324 -43.46648 24.02699  1.000 30.13714 ? 100 LYS A C    1 
ATOM   1531 O O    . LYS A 1 100 ? -17.80288 -42.57152 24.15917  1.000 28.37866 ? 100 LYS A O    1 
ATOM   1532 C CB   . LYS A 1 100 ? -18.61027 -44.74922 26.16643  1.000 39.65150 ? 100 LYS A CB   1 
ATOM   1533 C CG   . LYS A 1 100 ? -18.29757 -46.01531 26.92794  1.000 53.43558 ? 100 LYS A CG   1 
ATOM   1534 C CD   . LYS A 1 100 ? -18.68543 -45.85409 28.38942  1.000 66.85459 ? 100 LYS A CD   1 
ATOM   1535 C CE   . LYS A 1 100 ? -18.11297 -46.96293 29.25094  1.000 67.91932 ? 100 LYS A CE   1 
ATOM   1536 N NZ   . LYS A 1 100 ? -18.60079 -46.88252 30.65719  1.000 67.90584 ? 100 LYS A NZ   1 
ATOM   1537 H H    . LYS A 1 100 ? -16.56261 -45.44223 24.98704  1.000 38.69361 ? 100 LYS A H    1 
ATOM   1538 H HA   . LYS A 1 100 ? -19.06669 -45.47394 24.32299  1.000 43.30895 ? 100 LYS A HA   1 
ATOM   1539 H HB2  . LYS A 1 100 ? -18.02858 -44.05336 26.51039  1.000 47.60457 ? 100 LYS A HB2  1 
ATOM   1540 H HB3  . LYS A 1 100 ? -19.53701 -44.52532 26.34512  1.000 47.60457 ? 100 LYS A HB3  1 
ATOM   1541 H HG2  . LYS A 1 100 ? -18.80038 -46.75504 26.55261  1.000 64.14547 ? 100 LYS A HG2  1 
ATOM   1542 H HG3  . LYS A 1 100 ? -17.34682 -46.20079 26.87723  1.000 64.14547 ? 100 LYS A HG3  1 
ATOM   1543 H HD2  . LYS A 1 100 ? -18.34552 -45.00755 28.71916  1.000 80.24829 ? 100 LYS A HD2  1 
ATOM   1544 H HD3  . LYS A 1 100 ? -19.65195 -45.87689 28.46834  1.000 80.24829 ? 100 LYS A HD3  1 
ATOM   1545 H HE2  . LYS A 1 100 ? -18.37958 -47.82119 28.88598  1.000 81.52596 ? 100 LYS A HE2  1 
ATOM   1546 H HE3  . LYS A 1 100 ? -17.14556 -46.89275 29.26097  1.000 81.52596 ? 100 LYS A HE3  1 
ATOM   1547 H HZ1  . LYS A 1 100 ? -18.37901 -46.09695 31.01187  1.000 81.50979 ? 100 LYS A HZ1  1 
ATOM   1548 H HZ2  . LYS A 1 100 ? -19.48635 -46.96896 30.67760  1.000 81.50979 ? 100 LYS A HZ2  1 
ATOM   1549 H HZ3  . LYS A 1 100 ? -18.23586 -47.53239 31.14360  1.000 81.50979 ? 100 LYS A HZ3  1 
ATOM   1550 N N    . TYR A 1 101 ? -19.76394 -43.29989 23.33208  1.000 29.20490 ? 101 TYR A N    1 
ATOM   1551 C CA   . TYR A 1 101 ? -19.95499 -42.06833 22.58562  1.000 30.63635 ? 101 TYR A CA   1 
ATOM   1552 C C    . TYR A 1 101 ? -21.43387 -41.73964 22.46716  1.000 31.17101 ? 101 TYR A C    1 
ATOM   1553 O O    . TYR A 1 101 ? -22.30497 -42.60278 22.60981  1.000 28.04694 ? 101 TYR A O    1 
ATOM   1554 C CB   . TYR A 1 101 ? -19.31737 -42.15614 21.19006  1.000 27.71082 ? 101 TYR A CB   1 
ATOM   1555 C CG   . TYR A 1 101 ? -20.06184 -43.05774 20.22529  1.000 25.29145 ? 101 TYR A CG   1 
ATOM   1556 C CD1  . TYR A 1 101 ? -21.05722 -42.55260 19.39757  1.000 27.27778 ? 101 TYR A CD1  1 
ATOM   1557 C CD2  . TYR A 1 101 ? -19.76344 -44.41232 20.13546  1.000 31.83397 ? 101 TYR A CD2  1 
ATOM   1558 C CE1  . TYR A 1 101 ? -21.73937 -43.37205 18.51530  1.000 29.81827 ? 101 TYR A CE1  1 
ATOM   1559 C CE2  . TYR A 1 101 ? -20.43935 -45.23747 19.25574  1.000 29.57377 ? 101 TYR A CE2  1 
ATOM   1560 C CZ   . TYR A 1 101 ? -21.42607 -44.71050 18.44790  1.000 30.41323 ? 101 TYR A CZ   1 
ATOM   1561 O OH   . TYR A 1 101 ? -22.10563 -45.52215 17.56999  1.000 33.03276 ? 101 TYR A OH   1 
ATOM   1562 H H    . TYR A 1 101 ? -20.40663 -43.86901 23.28050  1.000 35.06866 ? 101 TYR A H    1 
ATOM   1563 H HA   . TYR A 1 101 ? -19.53924 -41.34488 23.08026  1.000 36.78639 ? 101 TYR A HA   1 
ATOM   1564 H HB2  . TYR A 1 101 ? -19.29299 -41.26694 20.80324  1.000 33.27576 ? 101 TYR A HB2  1 
ATOM   1565 H HB3  . TYR A 1 101 ? -18.41612 -42.50292 21.28165  1.000 33.27576 ? 101 TYR A HB3  1 
ATOM   1566 H HD1  . TYR A 1 101 ? -21.26871 -41.64784 19.43722  1.000 32.75611 ? 101 TYR A HD1  1 
ATOM   1567 H HD2  . TYR A 1 101 ? -19.09719 -44.77003 20.67681  1.000 38.22354 ? 101 TYR A HD2  1 
ATOM   1568 H HE1  . TYR A 1 101 ? -22.40606 -43.02009 17.97073  1.000 35.80470 ? 101 TYR A HE1  1 
ATOM   1569 H HE2  . TYR A 1 101 ? -20.23016 -46.14242 19.20876  1.000 35.51130 ? 101 TYR A HE2  1 
ATOM   1570 H HH   . TYR A 1 101 ? -22.67715 -45.07397 17.14799  1.000 39.66209 ? 101 TYR A HH   1 
ATOM   1571 N N    . LYS A 1 102 ? -21.68769 -40.45761 22.20409  1.000 26.08628 ? 102 LYS A N    1 
ATOM   1572 C CA   . LYS A 1 102 ? -23.00587 -39.90222 21.94459  1.000 31.18578 ? 102 LYS A CA   1 
ATOM   1573 C C    . LYS A 1 102 ? -22.88520 -38.91780 20.79051  1.000 26.83939 ? 102 LYS A C    1 
ATOM   1574 O O    . LYS A 1 102 ? -21.83554 -38.29850 20.59850  1.000 28.85755 ? 102 LYS A O    1 
ATOM   1575 C CB   . LYS A 1 102 ? -23.56850 -39.17224 23.17596  1.000 33.66268 ? 102 LYS A CB   1 
ATOM   1576 C CG   . LYS A 1 102 ? -24.60535 -39.94355 23.96698  1.000 45.01928 ? 102 LYS A CG   1 
ATOM   1577 C CD   . LYS A 1 102 ? -24.78490 -39.34831 25.36393  1.000 54.66647 ? 102 LYS A CD   1 
ATOM   1578 C CE   . LYS A 1 102 ? -25.93955 -39.99958 26.12088  1.000 79.95429 ? 102 LYS A CE   1 
ATOM   1579 N NZ   . LYS A 1 102 ? -26.02232 -39.53625 27.53844  1.000 69.17579 ? 102 LYS A NZ   1 
ATOM   1580 H H    . LYS A 1 102 ? -21.07292 -39.85724 22.16926  1.000 31.32632 ? 102 LYS A H    1 
ATOM   1581 H HA   . LYS A 1 102 ? -23.62258 -40.61129 21.70418  1.000 37.44572 ? 102 LYS A HA   1 
ATOM   1582 H HB2  . LYS A 1 102 ? -22.83325 -38.97497 23.77712  1.000 40.41799 ? 102 LYS A HB2  1 
ATOM   1583 H HB3  . LYS A 1 102 ? -23.98475 -38.34787 22.87923  1.000 40.41799 ? 102 LYS A HB3  1 
ATOM   1584 H HG2  . LYS A 1 102 ? -25.45770 -39.90559 23.50550  1.000 54.04591 ? 102 LYS A HG2  1 
ATOM   1585 H HG3  . LYS A 1 102 ? -24.31971 -40.86577 24.06089  1.000 54.04591 ? 102 LYS A HG3  1 
ATOM   1586 H HD2  . LYS A 1 102 ? -23.97240 -39.48491 25.87586  1.000 65.62254 ? 102 LYS A HD2  1 
ATOM   1587 H HD3  . LYS A 1 102 ? -24.97179 -38.39976 25.28503  1.000 65.62254 ? 102 LYS A HD3  1 
ATOM   1588 H HE2  . LYS A 1 102 ? -26.77458 -39.77532 25.68117  1.000 95.96793 ? 102 LYS A HE2  1 
ATOM   1589 H HE3  . LYS A 1 102 ? -25.81463 -40.96149 26.12492  1.000 95.96793 ? 102 LYS A HE3  1 
ATOM   1590 H HZ1  . LYS A 1 102 ? -26.69765 -39.94206 27.95239  1.000 83.03372 ? 102 LYS A HZ1  1 
ATOM   1591 H HZ2  . LYS A 1 102 ? -25.26522 -39.72691 27.96570  1.000 83.03372 ? 102 LYS A HZ2  1 
ATOM   1592 H HZ3  . LYS A 1 102 ? -26.15469 -38.65652 27.56392  1.000 83.03372 ? 102 LYS A HZ3  1 
ATOM   1593 N N    . PHE A 1 103 ? -23.96210 -38.78094 20.02105  1.000 22.62276 ? 103 PHE A N    1 
ATOM   1594 C CA   . PHE A 1 103 ? -24.10198 -37.70347 19.04859  1.000 25.60711 ? 103 PHE A CA   1 
ATOM   1595 C C    . PHE A 1 103 ? -24.96813 -36.62335 19.68340  1.000 30.89799 ? 103 PHE A C    1 
ATOM   1596 O O    . PHE A 1 103 ? -26.11330 -36.89182 20.06430  1.000 29.17589 ? 103 PHE A O    1 
ATOM   1597 C CB   . PHE A 1 103 ? -24.74558 -38.17957 17.74371  1.000 29.47204 ? 103 PHE A CB   1 
ATOM   1598 C CG   . PHE A 1 103 ? -23.87767 -39.08270 16.90425  1.000 23.25831 ? 103 PHE A CG   1 
ATOM   1599 C CD1  . PHE A 1 103 ? -22.54146 -39.28826 17.20461  1.000 21.02336 ? 103 PHE A CD1  1 
ATOM   1600 C CD2  . PHE A 1 103 ? -24.41217 -39.71643 15.79144  1.000 26.04724 ? 103 PHE A CD2  1 
ATOM   1601 C CE1  . PHE A 1 103 ? -21.76069 -40.11532 16.42102  1.000 26.59025 ? 103 PHE A CE1  1 
ATOM   1602 C CE2  . PHE A 1 103 ? -23.63646 -40.54414 15.00432  1.000 27.74401 ? 103 PHE A CE2  1 
ATOM   1603 C CZ   . PHE A 1 103 ? -22.30829 -40.74389 15.31886  1.000 26.38015 ? 103 PHE A CZ   1 
ATOM   1604 H H    . PHE A 1 103 ? -24.63841 -39.31161 20.04550  1.000 27.17009 ? 103 PHE A H    1 
ATOM   1605 H HA   . PHE A 1 103 ? -23.22385 -37.35384 18.83056  1.000 30.75131 ? 103 PHE A HA   1 
ATOM   1606 H HB2  . PHE A 1 103 ? -25.55383 -38.67030 17.96008  1.000 35.38923 ? 103 PHE A HB2  1 
ATOM   1607 H HB3  . PHE A 1 103 ? -24.96338 -37.40209 17.20614  1.000 35.38923 ? 103 PHE A HB3  1 
ATOM   1608 H HD1  . PHE A 1 103 ? -22.16562 -38.86462 17.94228  1.000 25.25081 ? 103 PHE A HD1  1 
ATOM   1609 H HD2  . PHE A 1 103 ? -25.30596 -39.58166 15.57262  1.000 31.27947 ? 103 PHE A HD2  1 
ATOM   1610 H HE1  . PHE A 1 103 ? -20.86569 -40.24931 16.63530  1.000 31.93108 ? 103 PHE A HE1  1 
ATOM   1611 H HE2  . PHE A 1 103 ? -24.00857 -40.96603 14.26375  1.000 33.31559 ? 103 PHE A HE2  1 
ATOM   1612 H HZ   . PHE A 1 103 ? -21.78268 -41.30019 14.79051  1.000 31.67896 ? 103 PHE A HZ   1 
ATOM   1613 N N    . VAL A 1 104 ? -24.42984 -35.41222 19.79789  1.000 24.21922 ? 104 VAL A N    1 
ATOM   1614 C CA   . VAL A 1 104 ? -25.16200 -34.29710 20.38138  1.000 26.89752 ? 104 VAL A CA   1 
ATOM   1615 C C    . VAL A 1 104 ? -25.09642 -33.11594 19.42777  1.000 31.23866 ? 104 VAL A C    1 
ATOM   1616 O O    . VAL A 1 104 ? -24.11629 -32.93415 18.69930  1.000 28.44802 ? 104 VAL A O    1 
ATOM   1617 C CB   . VAL A 1 104 ? -24.61038 -33.89534 21.76960  1.000 28.14654 ? 104 VAL A CB   1 
ATOM   1618 C CG1  . VAL A 1 104 ? -24.14313 -35.11934 22.53254  1.000 30.56923 ? 104 VAL A CG1  1 
ATOM   1619 C CG2  . VAL A 1 104 ? -23.48288 -32.86566 21.64105  1.000 32.54764 ? 104 VAL A CG2  1 
ATOM   1620 H H    . VAL A 1 104 ? -23.63376 -35.21192 19.54151  1.000 29.08584 ? 104 VAL A H    1 
ATOM   1621 H HA   . VAL A 1 104 ? -26.09038 -34.55683 20.48884  1.000 32.29980 ? 104 VAL A HA   1 
ATOM   1622 H HB   . VAL A 1 104 ? -25.32636 -33.48052 22.27576  1.000 33.79863 ? 104 VAL A HB   1 
ATOM   1623 H HG11 . VAL A 1 104 ? -24.00826 -34.87928 23.46264  1.000 36.70586 ? 104 VAL A HG11 1 
ATOM   1624 H HG12 . VAL A 1 104 ? -24.81949 -35.81127 22.46425  1.000 36.70586 ? 104 VAL A HG12 1 
ATOM   1625 H HG13 . VAL A 1 104 ? -23.30966 -35.43235 22.14750  1.000 36.70586 ? 104 VAL A HG13 1 
ATOM   1626 H HG21 . VAL A 1 104 ? -22.98960 -32.83166 22.47557  1.000 39.07995 ? 104 VAL A HG21 1 
ATOM   1627 H HG22 . VAL A 1 104 ? -22.89285 -33.13196 20.91866  1.000 39.07995 ? 104 VAL A HG22 1 
ATOM   1628 H HG23 . VAL A 1 104 ? -23.86908 -31.99673 21.44945  1.000 39.07995 ? 104 VAL A HG23 1 
ATOM   1629 N N    . ARG A 1 105 ? -26.14752 -32.30436 19.44090  1.000 29.98008 ? 105 ARG A N    1 
ATOM   1630 C CA   . ARG A 1 105 ? -26.17607 -31.05272 18.69609  1.000 30.12680 ? 105 ARG A CA   1 
ATOM   1631 C C    . ARG A 1 105 ? -25.91000 -29.92378 19.68296  1.000 33.90890 ? 105 ARG A C    1 
ATOM   1632 O O    . ARG A 1 105 ? -26.73256 -29.65094 20.56396  1.000 31.12550 ? 105 ARG A O    1 
ATOM   1633 C CB   . ARG A 1 105 ? -27.50918 -30.87216 17.97705  1.000 33.18193 ? 105 ARG A CB   1 
ATOM   1634 C CG   . ARG A 1 105 ? -27.58724 -29.61323 17.13251  1.000 32.20547 ? 105 ARG A CG   1 
ATOM   1635 C CD   . ARG A 1 105 ? -28.71309 -29.69283 16.12394  1.000 33.45609 ? 105 ARG A CD   1 
ATOM   1636 N NE   . ARG A 1 105 ? -28.81818 -28.47019 15.33820  1.000 36.45201 ? 105 ARG A NE   1 
ATOM   1637 C CZ   . ARG A 1 105 ? -28.19784 -28.25654 14.18554  1.000 32.74131 ? 105 ARG A CZ   1 
ATOM   1638 N NH1  . ARG A 1 105 ? -27.39030 -29.16152 13.65252  1.000 27.12833 ? 105 ARG A NH1  1 
ATOM   1639 N NH2  . ARG A 1 105 ? -28.39530 -27.10550 13.54931  1.000 26.90097 ? 105 ARG A NH2  1 
ATOM   1640 H H    . ARG A 1 105 ? -26.86892 -32.46069 19.88220  1.000 35.99887 ? 105 ARG A H    1 
ATOM   1641 H HA   . ARG A 1 105 ? -25.47852 -31.05026 18.02206  1.000 36.17494 ? 105 ARG A HA   1 
ATOM   1642 H HB2  . ARG A 1 105 ? -27.65138 -31.63110 17.38995  1.000 39.84110 ? 105 ARG A HB2  1 
ATOM   1643 H HB3  . ARG A 1 105 ? -28.21649 -30.82797 18.63936  1.000 39.84110 ? 105 ARG A HB3  1 
ATOM   1644 H HG2  . ARG A 1 105 ? -27.74683 -28.84911 17.70831  1.000 38.66934 ? 105 ARG A HG2  1 
ATOM   1645 H HG3  . ARG A 1 105 ? -26.75348 -29.49709 16.65058  1.000 38.66934 ? 105 ARG A HG3  1 
ATOM   1646 H HD2  . ARG A 1 105 ? -28.54828 -30.43146 15.51718  1.000 40.17009 ? 105 ARG A HD2  1 
ATOM   1647 H HD3  . ARG A 1 105 ? -29.55262 -29.82789 16.59069  1.000 40.17009 ? 105 ARG A HD3  1 
ATOM   1648 H HE   . ARG A 1 105 ? -29.31885 -27.84141 15.64411  1.000 43.76519 ? 105 ARG A HE   1 
ATOM   1649 H HH11 . ARG A 1 105 ? -27.25758 -29.90976 14.05517  1.000 32.57677 ? 105 ARG A HH11 1 
ATOM   1650 H HH12 . ARG A 1 105 ? -26.99881 -29.00073 12.90386  1.000 32.57677 ? 105 ARG A HH12 1 
ATOM   1651 H HH21 . ARG A 1 105 ? -28.91912 -26.51238 13.88610  1.000 32.30394 ? 105 ARG A HH21 1 
ATOM   1652 H HH22 . ARG A 1 105 ? -27.99918 -26.95428 12.80110  1.000 32.30394 ? 105 ARG A HH22 1 
ATOM   1653 N N    . ILE A 1 106 ? -24.76115 -29.27042 19.52739  1.000 29.32393 ? 106 ILE A N    1 
ATOM   1654 C CA   . ILE A 1 106 ? -24.32241 -28.27929 20.49519  1.000 32.10453 ? 106 ILE A CA   1 
ATOM   1655 C C    . ILE A 1 106 ? -25.07222 -26.96910 20.26964  1.000 32.46879 ? 106 ILE A C    1 
ATOM   1656 O O    . ILE A 1 106 ? -25.57162 -26.68227 19.17849  1.000 30.97237 ? 106 ILE A O    1 
ATOM   1657 C CB   . ILE A 1 106 ? -22.79723 -28.08693 20.40699  1.000 31.95125 ? 106 ILE A CB   1 
ATOM   1658 C CG1  . ILE A 1 106 ? -22.21352 -27.86810 21.80333  1.000 35.80729 ? 106 ILE A CG1  1 
ATOM   1659 C CG2  . ILE A 1 106 ? -22.44585 -26.92783 19.48363  1.000 32.74586 ? 106 ILE A CG2  1 
ATOM   1660 C CD1  . ILE A 1 106 ? -20.71514 -27.74616 21.82660  1.000 44.93955 ? 106 ILE A CD1  1 
ATOM   1661 H H    . ILE A 1 106 ? -24.21975 -29.38487 18.86908  1.000 35.21150 ? 106 ILE A H    1 
ATOM   1662 H HA   . ILE A 1 106 ? -24.53757 -28.58331 21.39083  1.000 38.54821 ? 106 ILE A HA   1 
ATOM   1663 H HB   . ILE A 1 106 ? -22.40951 -28.89302 20.03178  1.000 38.36428 ? 106 ILE A HB   1 
ATOM   1664 H HG12 . ILE A 1 106 ? -22.58204 -27.04903 22.16970  1.000 42.99153 ? 106 ILE A HG12 1 
ATOM   1665 H HG13 . ILE A 1 106 ? -22.45710 -28.62133 22.36388  1.000 42.99153 ? 106 ILE A HG13 1 
ATOM   1666 H HG21 . ILE A 1 106 ? -22.99075 -26.98533 18.68321  1.000 39.31781 ? 106 ILE A HG21 1 
ATOM   1667 H HG22 . ILE A 1 106 ? -21.50637 -26.98460 19.24900  1.000 39.31781 ? 106 ILE A HG22 1 
ATOM   1668 H HG23 . ILE A 1 106 ? -22.62185 -26.09255 19.94431  1.000 39.31781 ? 106 ILE A HG23 1 
ATOM   1669 H HD11 . ILE A 1 106 ? -20.39654 -27.93818 22.72244  1.000 53.95024 ? 106 ILE A HD11 1 
ATOM   1670 H HD12 . ILE A 1 106 ? -20.33686 -28.38063 21.19791  1.000 53.95024 ? 106 ILE A HD12 1 
ATOM   1671 H HD13 . ILE A 1 106 ? -20.46784 -26.84283 21.57411  1.000 53.95024 ? 106 ILE A HD13 1 
ATOM   1672 N N    . GLN A 1 107 ? -25.16503 -26.16003 21.34174  1.000 35.88581 ? 107 GLN A N    1 
ATOM   1673 C CA   . GLN A 1 107 ? -25.81935 -24.86063 21.29254  1.000 33.35092 ? 107 GLN A CA   1 
ATOM   1674 C C    . GLN A 1 107 ? -24.80235 -23.76409 20.99000  1.000 29.96019 ? 107 GLN A C    1 
ATOM   1675 O O    . GLN A 1 107 ? -23.62624 -23.88664 21.34765  1.000 28.66167 ? 107 GLN A O    1 
ATOM   1676 C CB   . GLN A 1 107 ? -26.50648 -24.56380 22.62415  1.000 39.01009 ? 107 GLN A CB   1 
ATOM   1677 C CG   . GLN A 1 107 ? -27.83866 -25.27446 22.81306  1.000 41.71761 ? 107 GLN A CG   1 
ATOM   1678 C CD   . GLN A 1 107 ? -28.93577 -24.68679 21.94337  1.000 47.08164 ? 107 GLN A CD   1 
ATOM   1679 O OE1  . GLN A 1 107 ? -29.16922 -25.14245 20.82379  1.000 49.10581 ? 107 GLN A OE1  1 
ATOM   1680 N NE2  . GLN A 1 107 ? -29.61048 -23.66257 22.45403  1.000 51.60829 ? 107 GLN A NE2  1 
ATOM   1681 H H    . GLN A 1 107 ? -24.84883 -26.35228 22.11804  1.000 43.08575 ? 107 GLN A H    1 
ATOM   1682 H HA   . GLN A 1 107 ? -26.49236 -24.85685 20.59402  1.000 40.04388 ? 107 GLN A HA   1 
ATOM   1683 H HB2  . GLN A 1 107 ? -25.91978 -24.84287 23.34443  1.000 46.83488 ? 107 GLN A HB2  1 
ATOM   1684 H HB3  . GLN A 1 107 ? -26.67164 -23.60969 22.68156  1.000 46.83488 ? 107 GLN A HB3  1 
ATOM   1685 H HG2  . GLN A 1 107 ? -27.73577 -26.20983 22.57767  1.000 50.08390 ? 107 GLN A HG2  1 
ATOM   1686 H HG3  . GLN A 1 107 ? -28.11293 -25.19385 23.73998  1.000 50.08390 ? 107 GLN A HG3  1 
ATOM   1687 H HE21 . GLN A 1 107 ? -29.41591 -23.36753 23.23806  1.000 61.95272 ? 107 GLN A HE21 1 
ATOM   1688 H HE22 . GLN A 1 107 ? -30.24181 -23.29460 22.00057  1.000 61.95272 ? 107 GLN A HE22 1 
ATOM   1689 N N    . PRO A 1 108 ? -25.21401 -22.67858 20.33397  1.000 30.78663 ? 108 PRO A N    1 
ATOM   1690 C CA   . PRO A 1 108 ? -24.28872 -21.55715 20.13589  1.000 31.34644 ? 108 PRO A CA   1 
ATOM   1691 C C    . PRO A 1 108 ? -23.80564 -21.00922 21.47061  1.000 30.73167 ? 108 PRO A C    1 
ATOM   1692 O O    . PRO A 1 108 ? -24.58030 -20.85021 22.41680  1.000 28.00230 ? 108 PRO A O    1 
ATOM   1693 C CB   . PRO A 1 108 ? -25.12789 -20.53028 19.36614  1.000 30.78600 ? 108 PRO A CB   1 
ATOM   1694 C CG   . PRO A 1 108 ? -26.54351 -20.90335 19.63762  1.000 31.49516 ? 108 PRO A CG   1 
ATOM   1695 C CD   . PRO A 1 108 ? -26.55129 -22.39099 19.78722  1.000 33.13237 ? 108 PRO A CD   1 
ATOM   1696 H HA   . PRO A 1 108 ? -23.52907 -21.82268 19.59429  1.000 37.63851 ? 108 PRO A HA   1 
ATOM   1697 H HB2  . PRO A 1 108 ? -24.93617 -19.63704 19.69214  1.000 36.96597 ? 108 PRO A HB2  1 
ATOM   1698 H HB3  . PRO A 1 108 ? -24.93011 -20.58703 18.41822  1.000 36.96597 ? 108 PRO A HB3  1 
ATOM   1699 H HG2  . PRO A 1 108 ? -26.84431 -20.47427 20.45389  1.000 37.81697 ? 108 PRO A HG2  1 
ATOM   1700 H HG3  . PRO A 1 108 ? -27.10254 -20.62983 18.89359  1.000 37.81697 ? 108 PRO A HG3  1 
ATOM   1701 H HD2  . PRO A 1 108 ? -27.24508 -22.67309 20.40364  1.000 39.78162 ? 108 PRO A HD2  1 
ATOM   1702 H HD3  . PRO A 1 108 ? -26.67440 -22.82445 18.92824  1.000 39.78162 ? 108 PRO A HD3  1 
ATOM   1703 N N    . GLY A 1 109 ? -22.50502 -20.72657 21.54029  1.000 23.63759 ? 109 GLY A N    1 
ATOM   1704 C CA   . GLY A 1 109 ? -21.86367 -20.27955 22.75626  1.000 25.38393 ? 109 GLY A CA   1 
ATOM   1705 C C    . GLY A 1 109 ? -21.13200 -21.36561 23.51188  1.000 30.49026 ? 109 GLY A C    1 
ATOM   1706 O O    . GLY A 1 109 ? -20.31788 -21.04961 24.38548  1.000 25.59865 ? 109 GLY A O    1 
ATOM   1707 H H    . GLY A 1 109 ? -21.96610 -20.79067 20.87317  1.000 28.38789 ? 109 GLY A H    1 
ATOM   1708 H HA2  . GLY A 1 109 ? -21.22180 -19.58688 22.53466  1.000 30.48349 ? 109 GLY A HA2  1 
ATOM   1709 H HA3  . GLY A 1 109 ? -22.53766 -19.90829 23.34686  1.000 30.48349 ? 109 GLY A HA3  1 
ATOM   1710 N N    . GLN A 1 110 ? -21.39723 -22.62785 23.20257  1.000 25.41100 ? 110 GLN A N    1 
ATOM   1711 C CA   . GLN A 1 110 ? -20.67401 -23.73316 23.80688  1.000 27.92055 ? 110 GLN A CA   1 
ATOM   1712 C C    . GLN A 1 110 ? -19.38848 -23.99903 23.03309  1.000 30.84525 ? 110 GLN A C    1 
ATOM   1713 O O    . GLN A 1 110 ? -19.23062 -23.59050 21.88065  1.000 25.39993 ? 110 GLN A O    1 
ATOM   1714 C CB   . GLN A 1 110 ? -21.53716 -24.99645 23.84053  1.000 28.92981 ? 110 GLN A CB   1 
ATOM   1715 C CG   . GLN A 1 110 ? -22.86984 -24.83904 24.56819  1.000 32.89192 ? 110 GLN A CG   1 
ATOM   1716 C CD   . GLN A 1 110 ? -22.73447 -24.06792 25.88085  1.000 42.78116 ? 110 GLN A CD   1 
ATOM   1717 O OE1  . GLN A 1 110 ? -22.13067 -24.54709 26.83353  1.000 44.58027 ? 110 GLN A OE1  1 
ATOM   1718 N NE2  . GLN A 1 110 ? -23.21543 -22.82772 25.89391  1.000 44.40738 ? 110 GLN A NE2  1 
ATOM   1719 H H    . GLN A 1 110 ? -21.99909 -22.87119 22.63852  1.000 30.51598 ? 110 GLN A H    1 
ATOM   1720 H HA   . GLN A 1 110 ? -20.44530 -23.50785 24.72220  1.000 33.52744 ? 110 GLN A HA   1 
ATOM   1721 H HB2  . GLN A 1 110 ? -21.73208 -25.26090 22.92786  1.000 34.73855 ? 110 GLN A HB2  1 
ATOM   1722 H HB3  . GLN A 1 110 ? -21.03988 -25.69755 24.29007  1.000 34.73855 ? 110 GLN A HB3  1 
ATOM   1723 H HG2  . GLN A 1 110 ? -23.48711 -24.35511 23.99749  1.000 39.49308 ? 110 GLN A HG2  1 
ATOM   1724 H HG3  . GLN A 1 110 ? -23.22561 -25.71828 24.77131  1.000 39.49308 ? 110 GLN A HG3  1 
ATOM   1725 H HE21 . GLN A 1 110 ? -23.16270 -22.35358 26.60945  1.000 53.31163 ? 110 GLN A HE21 1 
ATOM   1726 H HE22 . GLN A 1 110 ? -23.57910 -22.50009 25.18680  1.000 53.31163 ? 110 GLN A HE22 1 
ATOM   1727 N N    . THR A 1 111 ? -18.45602 -24.67173 23.69627  1.000 26.80706 ? 111 THR A N    1 
ATOM   1728 C CA   . THR A 1 111 ? -17.13984 -24.94891 23.14688  1.000 27.56247 ? 111 THR A CA   1 
ATOM   1729 C C    . THR A 1 111 ? -16.97530 -26.44314 22.90096  1.000 27.33186 ? 111 THR A C    1 
ATOM   1730 O O    . THR A 1 111 ? -17.73232 -27.27326 23.41394  1.000 24.70437 ? 111 THR A O    1 
ATOM   1731 C CB   . THR A 1 111 ? -16.03646 -24.45019 24.08748  1.000 27.15994 ? 111 THR A CB   1 
ATOM   1732 O OG1  . THR A 1 111 ? -16.24700 -24.98309 25.40085  1.000 27.92166 ? 111 THR A OG1  1 
ATOM   1733 C CG2  . THR A 1 111 ? -16.03631 -22.93023 24.14257  1.000 28.98574 ? 111 THR A CG2  1 
ATOM   1734 H H    . THR A 1 111 ? -18.56774 -24.98589 24.48900  1.000 32.19125 ? 111 THR A H    1 
ATOM   1735 H HA   . THR A 1 111 ? -17.04445 -24.48971 22.29781  1.000 33.09774 ? 111 THR A HA   1 
ATOM   1736 H HB   . THR A 1 111 ? -15.17084 -24.74237 23.76154  1.000 32.61471 ? 111 THR A HB   1 
ATOM   1737 H HG1  . THR A 1 111 ? -16.98350 -24.71657 25.70437  1.000 33.52877 ? 111 THR A HG1  1 
ATOM   1738 H HG21 . THR A 1 111 ? -15.62202 -22.62814 24.96598  1.000 34.80566 ? 111 THR A HG21 1 
ATOM   1739 H HG22 . THR A 1 111 ? -15.54025 -22.57104 23.39036  1.000 34.80566 ? 111 THR A HG22 1 
ATOM   1740 H HG23 . THR A 1 111 ? -16.94655 -22.59689 24.10740  1.000 34.80566 ? 111 THR A HG23 1 
ATOM   1741 N N    . PHE A 1 112 ? -15.97427 -26.77545 22.09142  1.000 25.01799 ? 112 PHE A N    1 
ATOM   1742 C CA   . PHE A 1 112 ? -15.63570 -28.16642 21.83397  1.000 25.16577 ? 112 PHE A CA   1 
ATOM   1743 C C    . PHE A 1 112 ? -14.24453 -28.22285 21.22290  1.000 25.11135 ? 112 PHE A C    1 
ATOM   1744 O O    . PHE A 1 112 ? -13.72763 -27.22438 20.71591  1.000 24.02970 ? 112 PHE A O    1 
ATOM   1745 C CB   . PHE A 1 112 ? -16.66687 -28.83354 20.91766  1.000 25.19121 ? 112 PHE A CB   1 
ATOM   1746 C CG   . PHE A 1 112 ? -16.81237 -28.17258 19.57229  1.000 23.21572 ? 112 PHE A CG   1 
ATOM   1747 C CD1  . PHE A 1 112 ? -15.99985 -28.54434 18.51273  1.000 22.26311 ? 112 PHE A CD1  1 
ATOM   1748 C CD2  . PHE A 1 112 ? -17.77778 -27.20147 19.35939  1.000 26.45747 ? 112 PHE A CD2  1 
ATOM   1749 C CE1  . PHE A 1 112 ? -16.13490 -27.95130 17.27056  1.000 21.18584 ? 112 PHE A CE1  1 
ATOM   1750 C CE2  . PHE A 1 112 ? -17.91910 -26.60332 18.11802  1.000 29.09243 ? 112 PHE A CE2  1 
ATOM   1751 C CZ   . PHE A 1 112 ? -17.09563 -26.98005 17.07164  1.000 23.21608 ? 112 PHE A CZ   1 
ATOM   1752 H H    . PHE A 1 112 ? -15.47515 -26.20984 21.67842  1.000 30.04437 ? 112 PHE A H    1 
ATOM   1753 H HA   . PHE A 1 112 ? -15.61635 -28.65652 22.67082  1.000 30.22171 ? 112 PHE A HA   1 
ATOM   1754 H HB2  . PHE A 1 112 ? -16.39897 -29.75348 20.76655  1.000 30.25223 ? 112 PHE A HB2  1 
ATOM   1755 H HB3  . PHE A 1 112 ? -17.53285 -28.80756 21.35389  1.000 30.25223 ? 112 PHE A HB3  1 
ATOM   1756 H HD1  . PHE A 1 112 ? -15.35454 -29.20205 18.63884  1.000 26.73851 ? 112 PHE A HD1  1 
ATOM   1757 H HD2  . PHE A 1 112 ? -18.33717 -26.94846 20.05793  1.000 31.77174 ? 112 PHE A HD2  1 
ATOM   1758 H HE1  . PHE A 1 112 ? -15.57906 -28.20656 16.57001  1.000 25.44579 ? 112 PHE A HE1  1 
ATOM   1759 H HE2  . PHE A 1 112 ? -18.56699 -25.94895 17.98789  1.000 34.93369 ? 112 PHE A HE2  1 
ATOM   1760 H HZ   . PHE A 1 112 ? -17.18909 -26.58028 16.23716  1.000 27.88207 ? 112 PHE A HZ   1 
ATOM   1761 N N    . SER A 1 113 ? -13.64366 -29.40707 21.28677  1.000 21.46551 ? 113 SER A N    1 
ATOM   1762 C CA   . SER A 1 113 ? -12.31457 -29.63260 20.74091  1.000 17.53475 ? 113 SER A CA   1 
ATOM   1763 C C    . SER A 1 113 ? -12.41951 -30.15316 19.31511  1.000 23.80170 ? 113 SER A C    1 
ATOM   1764 O O    . SER A 1 113 ? -13.27444 -30.98738 19.01055  1.000 23.55223 ? 113 SER A O    1 
ATOM   1765 C CB   . SER A 1 113 ? -11.54065 -30.63024 21.60500  1.000 24.62611 ? 113 SER A CB   1 
ATOM   1766 O OG   . SER A 1 113 ? -11.06467 -30.02663 22.79849  1.000 26.68834 ? 113 SER A OG   1 
ATOM   1767 H H    . SER A 1 113 ? -13.99268 -30.10537 21.64755  1.000 25.78139 ? 113 SER A H    1 
ATOM   1768 H HA   . SER A 1 113 ? -11.82209 -28.79701 20.72838  1.000 21.06448 ? 113 SER A HA   1 
ATOM   1769 H HB2  . SER A 1 113 ? -12.12973 -31.36450 21.83901  1.000 29.57410 ? 113 SER A HB2  1 
ATOM   1770 H HB3  . SER A 1 113 ? -10.78290 -30.96147 21.09804  1.000 29.57410 ? 113 SER A HB3  1 
ATOM   1771 H HG   . SER A 1 113 ? -11.70936 -29.84466 23.30530  1.000 32.04879 ? 113 SER A HG   1 
ATOM   1772 N N    . VAL A 1 114 ? -11.54636 -29.65107 18.44482  1.000 24.64032 ? 114 VAL A N    1 
ATOM   1773 C CA   . VAL A 1 114 ? -11.44920 -30.09632 17.05881  1.000 17.68489 ? 114 VAL A CA   1 
ATOM   1774 C C    . VAL A 1 114 ? -10.14423 -30.86319 16.90653  1.000 19.65531 ? 114 VAL A C    1 
ATOM   1775 O O    . VAL A 1 114 ? -9.07579  -30.36097 17.27334  1.000 19.86891 ? 114 VAL A O    1 
ATOM   1776 C CB   . VAL A 1 114 ? -11.51725 -28.91170 16.07527  1.000 23.27533 ? 114 VAL A CB   1 
ATOM   1777 C CG1  . VAL A 1 114 ? -11.20442 -29.36199 14.64461  1.000 25.65387 ? 114 VAL A CG1  1 
ATOM   1778 C CG2  . VAL A 1 114 ? -12.89118 -28.24617 16.13097  1.000 24.50884 ? 114 VAL A CG2  1 
ATOM   1779 H H    . VAL A 1 114 ? -10.98269 -29.03207 18.64156  1.000 29.59116 ? 114 VAL A H    1 
ATOM   1780 H HA   . VAL A 1 114 ? -12.18576 -30.69431 16.85684  1.000 21.24464 ? 114 VAL A HA   1 
ATOM   1781 H HB   . VAL A 1 114 ? -10.84740 -28.26100 16.33754  1.000 27.95318 ? 114 VAL A HB   1 
ATOM   1782 H HG11 . VAL A 1 114 ? -10.31815 -29.75569 14.62412  1.000 30.80742 ? 114 VAL A HG11 1 
ATOM   1783 H HG12 . VAL A 1 114 ? -11.86399 -30.01744 14.36848  1.000 30.80742 ? 114 VAL A HG12 1 
ATOM   1784 H HG13 . VAL A 1 114 ? -11.23767 -28.59128 14.05656  1.000 30.80742 ? 114 VAL A HG13 1 
ATOM   1785 H HG21 . VAL A 1 114 ? -13.35729 -28.55003 16.92552  1.000 29.43338 ? 114 VAL A HG21 1 
ATOM   1786 H HG22 . VAL A 1 114 ? -12.77479 -27.28373 16.16350  1.000 29.43338 ? 114 VAL A HG22 1 
ATOM   1787 H HG23 . VAL A 1 114 ? -13.39353 -28.49201 15.33844  1.000 29.43338 ? 114 VAL A HG23 1 
ATOM   1788 N N    . LEU A 1 115 ? -10.23577 -32.08750 16.39591  1.000 21.50895 ? 115 LEU A N    1 
ATOM   1789 C CA   . LEU A 1 115 ? -9.06942  -32.86430 15.98990  1.000 19.61001 ? 115 LEU A CA   1 
ATOM   1790 C C    . LEU A 1 115 ? -8.95378  -32.69669 14.47886  1.000 22.67441 ? 115 LEU A C    1 
ATOM   1791 O O    . LEU A 1 115 ? -9.68501  -33.33207 13.71509  1.000 21.30034 ? 115 LEU A O    1 
ATOM   1792 C CB   . LEU A 1 115 ? -9.20648  -34.32722 16.40269  1.000 21.81797 ? 115 LEU A CB   1 
ATOM   1793 C CG   . LEU A 1 115 ? -7.98794  -35.20825 16.11355  1.000 25.18714 ? 115 LEU A CG   1 
ATOM   1794 C CD1  . LEU A 1 115 ? -6.77914  -34.76102 16.93420  1.000 27.17455 ? 115 LEU A CD1  1 
ATOM   1795 C CD2  . LEU A 1 115 ? -8.30947  -36.67565 16.38230  1.000 22.99948 ? 115 LEU A CD2  1 
ATOM   1796 H H    . LEU A 1 115 ? -10.98078 -32.49891 16.27218  1.000 25.83352 ? 115 LEU A H    1 
ATOM   1797 H HA   . LEU A 1 115 ? -8.26714  -32.52387 16.41576  1.000 23.55479 ? 115 LEU A HA   1 
ATOM   1798 H HB2  . LEU A 1 115 ? -9.36768  -34.36030 17.35863  1.000 26.20434 ? 115 LEU A HB2  1 
ATOM   1799 H HB3  . LEU A 1 115 ? -9.95988  -34.70912 15.92579  1.000 26.20434 ? 115 LEU A HB3  1 
ATOM   1800 H HG   . LEU A 1 115 ? -7.75616  -35.11737 15.17605  1.000 30.24734 ? 115 LEU A HG   1 
ATOM   1801 H HD11 . LEU A 1 115 ? -6.97354  -34.88544 17.87634  1.000 32.63224 ? 115 LEU A HD11 1 
ATOM   1802 H HD12 . LEU A 1 115 ? -6.01050  -35.29607 16.68158  1.000 32.63224 ? 115 LEU A HD12 1 
ATOM   1803 H HD13 . LEU A 1 115 ? -6.60388  -33.82425 16.75351  1.000 32.63224 ? 115 LEU A HD13 1 
ATOM   1804 H HD21 . LEU A 1 115 ? -8.85366  -37.01787 15.65590  1.000 27.62215 ? 115 LEU A HD21 1 
ATOM   1805 H HD22 . LEU A 1 115 ? -7.48010  -37.17557 16.43819  1.000 27.62215 ? 115 LEU A HD22 1 
ATOM   1806 H HD23 . LEU A 1 115 ? -8.79427  -36.74450 17.21963  1.000 27.62215 ? 115 LEU A HD23 1 
ATOM   1807 N N    . ALA A 1 116 ? -8.06232  -31.80634 14.05086  1.000 22.90414 ? 116 ALA A N    1 
ATOM   1808 C CA   . ALA A 1 116 ? -7.84809  -31.57959 12.62852  1.000 20.42291 ? 116 ALA A CA   1 
ATOM   1809 C C    . ALA A 1 116 ? -7.05403  -32.73986 12.04448  1.000 24.45477 ? 116 ALA A C    1 
ATOM   1810 O O    . ALA A 1 116 ? -5.98502  -33.08832 12.55600  1.000 26.80048 ? 116 ALA A O    1 
ATOM   1811 C CB   . ALA A 1 116 ? -7.11275  -30.25968 12.40255  1.000 21.88291 ? 116 ALA A CB   1 
ATOM   1812 H H    . ALA A 1 116 ? -7.57074  -31.32266 14.56468  1.000 27.50774 ? 116 ALA A H    1 
ATOM   1813 H HA   . ALA A 1 116 ? -8.70184  -31.52577 12.17124  1.000 24.53027 ? 116 ALA A HA   1 
ATOM   1814 H HB1  . ALA A 1 116 ? -6.89436  -30.17701 11.46107  1.000 26.28227 ? 116 ALA A HB1  1 
ATOM   1815 H HB2  . ALA A 1 116 ? -7.68779  -29.52728 12.67426  1.000 26.28227 ? 116 ALA A HB2  1 
ATOM   1816 H HB3  . ALA A 1 116 ? -6.30011  -30.25622 12.93216  1.000 26.28227 ? 116 ALA A HB3  1 
ATOM   1817 N N    . CYS A 1 117 ? -7.58177  -33.34513 10.98054  1.000 21.61730 ? 117 CYS A N    1 
ATOM   1818 C CA   . CYS A 1 117 ? -6.97770  -34.52226 10.37317  1.000 24.52877 ? 117 CYS A CA   1 
ATOM   1819 C C    . CYS A 1 117 ? -6.84437  -34.34377 8.86684   1.000 20.81751 ? 117 CYS A C    1 
ATOM   1820 O O    . CYS A 1 117 ? -7.58304  -33.57991 8.24177   1.000 22.50708 ? 117 CYS A O    1 
ATOM   1821 C CB   . CYS A 1 117 ? -7.80141  -35.78653 10.63711  1.000 27.51736 ? 117 CYS A CB   1 
ATOM   1822 S SG   . CYS A 1 117 ? -8.01666  -36.21472 12.36571  1.000 30.60656 ? 117 CYS A SG   1 
ATOM   1823 H H    . CYS A 1 117 ? -8.30181  -33.08538 10.58852  1.000 25.96353 ? 117 CYS A H    1 
ATOM   1824 H HA   . CYS A 1 117 ? -6.09094  -34.62811 10.75180  1.000 29.45730 ? 117 CYS A HA   1 
ATOM   1825 H HB2  . CYS A 1 117 ? -8.68522  -35.66022 10.25786  1.000 33.04361 ? 117 CYS A HB2  1 
ATOM   1826 H HB3  . CYS A 1 117 ? -7.35938  -36.53481 10.20631  1.000 33.04361 ? 117 CYS A HB3  1 
ATOM   1827 H HG   . CYS A 1 117 ? -8.68094  -35.36887 12.89794  1.000 36.75065 ? 117 CYS A HG   1 
ATOM   1828 N N    . TYR A 1 118 ? -5.89703  -35.08597 8.29007   1.000 26.04039 ? 118 TYR A N    1 
ATOM   1829 C CA   . TYR A 1 118 ? -5.70432  -35.16173 6.84689   1.000 21.04928 ? 118 TYR A CA   1 
ATOM   1830 C C    . TYR A 1 118 ? -5.32904  -36.59102 6.48879   1.000 24.59833 ? 118 TYR A C    1 
ATOM   1831 O O    . TYR A 1 118 ? -4.49086  -37.20151 7.15777   1.000 24.06380 ? 118 TYR A O    1 
ATOM   1832 C CB   . TYR A 1 118 ? -4.61718  -34.19056 6.36817   1.000 22.99063 ? 118 TYR A CB   1 
ATOM   1833 C CG   . TYR A 1 118 ? -4.93135  -32.75066 6.69966   1.000 27.14902 ? 118 TYR A CG   1 
ATOM   1834 C CD1  . TYR A 1 118 ? -5.63386  -31.95024 5.80833   1.000 26.82155 ? 118 TYR A CD1  1 
ATOM   1835 C CD2  . TYR A 1 118 ? -4.54629  -32.19778 7.91280   1.000 28.76490 ? 118 TYR A CD2  1 
ATOM   1836 C CE1  . TYR A 1 118 ? -5.93094  -30.64060 6.11071   1.000 27.32086 ? 118 TYR A CE1  1 
ATOM   1837 C CE2  . TYR A 1 118 ? -4.84409  -30.88563 8.22551   1.000 29.19386 ? 118 TYR A CE2  1 
ATOM   1838 C CZ   . TYR A 1 118 ? -5.53762  -30.11371 7.31924   1.000 25.87300 ? 118 TYR A CZ   1 
ATOM   1839 O OH   . TYR A 1 118 ? -5.84244  -28.80762 7.61680   1.000 30.86801 ? 118 TYR A OH   1 
ATOM   1840 H H    . TYR A 1 118 ? -5.33750  -35.56861 8.73005   1.000 31.27124 ? 118 TYR A H    1 
ATOM   1841 H HA   . TYR A 1 118 ? -6.52949  -34.92878 6.39330   1.000 25.28192 ? 118 TYR A HA   1 
ATOM   1842 H HB2  . TYR A 1 118 ? -3.77770  -34.42081 6.79612   1.000 27.61154 ? 118 TYR A HB2  1 
ATOM   1843 H HB3  . TYR A 1 118 ? -4.52981  -34.26464 5.40496   1.000 27.61154 ? 118 TYR A HB3  1 
ATOM   1844 H HD1  . TYR A 1 118 ? -5.90816  -32.30494 4.99356   1.000 32.20864 ? 118 TYR A HD1  1 
ATOM   1845 H HD2  . TYR A 1 118 ? -4.07995  -32.71934 8.52551   1.000 34.54065 ? 118 TYR A HD2  1 
ATOM   1846 H HE1  . TYR A 1 118 ? -6.39550  -30.11426 5.50074   1.000 32.80781 ? 118 TYR A HE1  1 
ATOM   1847 H HE2  . TYR A 1 118 ? -4.57860  -30.52623 9.04113   1.000 35.05541 ? 118 TYR A HE2  1 
ATOM   1848 H HH   . TYR A 1 118 ? -6.58175  -28.76838 8.01363   1.000 37.06439 ? 118 TYR A HH   1 
ATOM   1849 N N    . ASN A 1 119 ? -5.95156  -37.12515 5.43989   1.000 23.87954 ? 119 ASN A N    1 
ATOM   1850 C CA   . ASN A 1 119 ? -5.70120  -38.50198 5.01564   1.000 28.54580 ? 119 ASN A CA   1 
ATOM   1851 C C    . ASN A 1 119 ? -5.96185  -39.48769 6.14865   1.000 27.55187 ? 119 ASN A C    1 
ATOM   1852 O O    . ASN A 1 119 ? -5.31055  -40.53210 6.24201   1.000 28.86292 ? 119 ASN A O    1 
ATOM   1853 C CB   . ASN A 1 119 ? -4.27195  -38.66398 4.49470   1.000 28.13608 ? 119 ASN A CB   1 
ATOM   1854 C CG   . ASN A 1 119 ? -3.99813  -37.80467 3.28392   1.000 31.76851 ? 119 ASN A CG   1 
ATOM   1855 O OD1  . ASN A 1 119 ? -3.26620  -36.81790 3.36005   1.000 37.62865 ? 119 ASN A OD1  1 
ATOM   1856 N ND2  . ASN A 1 119 ? -4.58484  -38.17586 2.15378   1.000 37.71066 ? 119 ASN A ND2  1 
ATOM   1857 H H    . ASN A 1 119 ? -6.52653  -36.70814 4.95501   1.000 28.67823 ? 119 ASN A H    1 
ATOM   1858 H HA   . ASN A 1 119 ? -6.31176  -38.71549 4.29278   1.000 34.27774 ? 119 ASN A HA   1 
ATOM   1859 H HB2  . ASN A 1 119 ? -3.64900  -38.40799 5.19277   1.000 33.78607 ? 119 ASN A HB2  1 
ATOM   1860 H HB3  . ASN A 1 119 ? -4.12836  -39.59029 4.24525   1.000 33.78607 ? 119 ASN A HB3  1 
ATOM   1861 H HD21 . ASN A 1 119 ? -4.46115  -37.71992 1.43515   1.000 45.27557 ? 119 ASN A HD21 1 
ATOM   1862 H HD22 . ASN A 1 119 ? -5.08895  -38.87247 2.13963   1.000 45.27557 ? 119 ASN A HD22 1 
ATOM   1863 N N    . GLY A 1 120 ? -6.90738  -39.15570 7.02565   1.000 24.94123 ? 120 GLY A N    1 
ATOM   1864 C CA   . GLY A 1 120 ? -7.23964  -40.01890 8.13909   1.000 27.88889 ? 120 GLY A CA   1 
ATOM   1865 C C    . GLY A 1 120 ? -6.24459  -40.01914 9.27671   1.000 30.47820 ? 120 GLY A C    1 
ATOM   1866 O O    . GLY A 1 120 ? -6.36625  -40.85319 10.17988  1.000 29.37368 ? 120 GLY A O    1 
ATOM   1867 H H    . GLY A 1 120 ? -7.36929  -38.43107 6.99185   1.000 29.95225 ? 120 GLY A H    1 
ATOM   1868 H HA2  . GLY A 1 120 ? -8.09703  -39.74247 8.49879   1.000 33.48944 ? 120 GLY A HA2  1 
ATOM   1869 H HA3  . GLY A 1 120 ? -7.31286  -40.92938 7.81264   1.000 33.48944 ? 120 GLY A HA3  1 
ATOM   1870 N N    . SER A 1 121 ? -5.26946  -39.11111 9.27176   1.000 25.60681 ? 121 SER A N    1 
ATOM   1871 C CA   . SER A 1 121 ? -4.24233  -39.05747 10.29918  1.000 26.71635 ? 121 SER A CA   1 
ATOM   1872 C C    . SER A 1 121 ? -4.32907  -37.74066 11.06152  1.000 27.67144 ? 121 SER A C    1 
ATOM   1873 O O    . SER A 1 121 ? -4.36591  -36.66978 10.43742  1.000 25.21014 ? 121 SER A O    1 
ATOM   1874 C CB   . SER A 1 121 ? -2.84220  -39.21452 9.68526   1.000 28.22964 ? 121 SER A CB   1 
ATOM   1875 O OG   . SER A 1 121 ? -2.60054  -40.56798 9.34097   1.000 36.70067 ? 121 SER A OG   1 
ATOM   1876 H H    . SER A 1 121 ? -5.18365  -38.50420 8.66852   1.000 30.75095 ? 121 SER A H    1 
ATOM   1877 H HA   . SER A 1 121 ? -4.38411  -39.78294 10.92726  1.000 32.08240 ? 121 SER A HA   1 
ATOM   1878 H HB2  . SER A 1 121 ? -2.78337  -38.66847 8.88572   1.000 33.89834 ? 121 SER A HB2  1 
ATOM   1879 H HB3  . SER A 1 121 ? -2.17835  -38.92836 10.33203  1.000 33.89834 ? 121 SER A HB3  1 
ATOM   1880 H HG   . SER A 1 121 ? -1.79661  -40.66891 9.11934   1.000 44.06358 ? 121 SER A HG   1 
ATOM   1881 N N    . PRO A 1 122 ? -4.36989  -37.76879 12.39380  1.000 28.39723 ? 122 PRO A N    1 
ATOM   1882 C CA   . PRO A 1 122 ? -4.47531  -36.51589 13.15032  1.000 28.05983 ? 122 PRO A CA   1 
ATOM   1883 C C    . PRO A 1 122 ? -3.28209  -35.59824 12.93090  1.000 28.95980 ? 122 PRO A C    1 
ATOM   1884 O O    . PRO A 1 122 ? -2.13395  -36.04160 12.85467  1.000 33.42481 ? 122 PRO A O    1 
ATOM   1885 C CB   . PRO A 1 122 ? -4.55466  -36.99487 14.60358  1.000 32.97337 ? 122 PRO A CB   1 
ATOM   1886 C CG   . PRO A 1 122 ? -5.17777  -38.33700 14.50892  1.000 31.25413 ? 122 PRO A CG   1 
ATOM   1887 C CD   . PRO A 1 122 ? -4.56201  -38.93887 13.27013  1.000 35.09829 ? 122 PRO A CD   1 
ATOM   1888 H HA   . PRO A 1 122 ? -5.28538  -36.04333 12.90259  1.000 33.69458 ? 122 PRO A HA   1 
ATOM   1889 H HB2  . PRO A 1 122 ? -3.66499  -37.04793 14.98645  1.000 39.59082 ? 122 PRO A HB2  1 
ATOM   1890 H HB3  . PRO A 1 122 ? -5.10461  -36.38933 15.12491  1.000 39.59082 ? 122 PRO A HB3  1 
ATOM   1891 H HG2  . PRO A 1 122 ? -4.96416  -38.86142 15.29648  1.000 37.52774 ? 122 PRO A HG2  1 
ATOM   1892 H HG3  . PRO A 1 122 ? -6.13978  -38.25357 14.41679  1.000 37.52774 ? 122 PRO A HG3  1 
ATOM   1893 H HD2  . PRO A 1 122 ? -3.71318  -39.36111 13.47531  1.000 42.14073 ? 122 PRO A HD2  1 
ATOM   1894 H HD3  . PRO A 1 122 ? -5.16257  -39.58223 12.86230  1.000 42.14073 ? 122 PRO A HD3  1 
ATOM   1895 N N    . SER A 1 123 ? -3.57304  -34.30171 12.83404  1.000 27.95938 ? 123 SER A N    1 
ATOM   1896 C CA   . SER A 1 123 ? -2.56689  -33.25652 12.69435  1.000 28.97772 ? 123 SER A CA   1 
ATOM   1897 C C    . SER A 1 123 ? -2.39952  -32.41404 13.94868  1.000 30.76564 ? 123 SER A C    1 
ATOM   1898 O O    . SER A 1 123 ? -1.28500  -31.98341 14.25156  1.000 29.63637 ? 123 SER A O    1 
ATOM   1899 C CB   . SER A 1 123 ? -2.93076  -32.33295 11.52698  1.000 34.44999 ? 123 SER A CB   1 
ATOM   1900 O OG   . SER A 1 123 ? -1.84743  -31.48877 11.17976  1.000 45.77686 ? 123 SER A OG   1 
ATOM   1901 H H    . SER A 1 123 ? -4.37607  -33.99419 12.84751  1.000 33.57403 ? 123 SER A H    1 
ATOM   1902 H HA   . SER A 1 123 ? -1.71298  -33.67186 12.49626  1.000 34.79604 ? 123 SER A HA   1 
ATOM   1903 H HB2  . SER A 1 123 ? -3.16398  -32.87632 10.75804  1.000 41.36277 ? 123 SER A HB2  1 
ATOM   1904 H HB3  . SER A 1 123 ? -3.68656  -31.78288 11.78601  1.000 41.36277 ? 123 SER A HB3  1 
ATOM   1905 H HG   . SER A 1 123 ? -1.23507  -31.93940 10.82262  1.000 54.95500 ? 123 SER A HG   1 
ATOM   1906 N N    . GLY A 1 124 ? -3.47976  -32.16198 14.67903  1.000 25.07567 ? 124 GLY A N    1 
ATOM   1907 C CA   . GLY A 1 124 ? -3.41762  -31.33327 15.87210  1.000 23.67657 ? 124 GLY A CA   1 
ATOM   1908 C C    . GLY A 1 124 ? -4.81139  -31.14183 16.42818  1.000 25.42623 ? 124 GLY A C    1 
ATOM   1909 O O    . GLY A 1 124 ? -5.81329  -31.49029 15.79495  1.000 24.42810 ? 124 GLY A O    1 
ATOM   1910 H H    . GLY A 1 124 ? -4.26623  -32.46190 14.50266  1.000 30.11358 ? 124 GLY A H    1 
ATOM   1911 H HA2  . GLY A 1 124 ? -2.86363  -31.75939 16.54472  1.000 28.43467 ? 124 GLY A HA2  1 
ATOM   1912 H HA3  . GLY A 1 124 ? -3.04072  -30.46611 15.65561  1.000 28.43467 ? 124 GLY A HA3  1 
ATOM   1913 N N    . VAL A 1 125 ? -4.86604  -30.57712 17.63125  1.000 21.80647 ? 125 VAL A N    1 
ATOM   1914 C CA   . VAL A 1 125 ? -6.12259  -30.41232 18.35143  1.000 23.08150 ? 125 VAL A CA   1 
ATOM   1915 C C    . VAL A 1 125 ? -6.18072  -29.00611 18.93448  1.000 24.17460 ? 125 VAL A C    1 
ATOM   1916 O O    . VAL A 1 125 ? -5.17875  -28.49078 19.44253  1.000 22.47805 ? 125 VAL A O    1 
ATOM   1917 C CB   . VAL A 1 125 ? -6.28460  -31.48925 19.45076  1.000 25.09646 ? 125 VAL A CB   1 
ATOM   1918 C CG1  . VAL A 1 125 ? -5.17364  -31.38397 20.48572  1.000 29.50158 ? 125 VAL A CG1  1 
ATOM   1919 C CG2  . VAL A 1 125 ? -7.65751  -31.39487 20.10703  1.000 23.68182 ? 125 VAL A CG2  1 
ATOM   1920 H H    . VAL A 1 125 ? -4.17956  -30.27852 18.05454  1.000 26.19055 ? 125 VAL A H    1 
ATOM   1921 H HA   . VAL A 1 125 ? -6.86474  -30.49857 17.73282  1.000 27.72058 ? 125 VAL A HA   1 
ATOM   1922 H HB   . VAL A 1 125 ? -6.21615  -32.36321 19.03554  1.000 30.13853 ? 125 VAL A HB   1 
ATOM   1923 H HG11 . VAL A 1 125 ? -4.60506  -30.63026 20.26313  1.000 35.42468 ? 125 VAL A HG11 1 
ATOM   1924 H HG12 . VAL A 1 125 ? -5.56935  -31.25252 21.36153  1.000 35.42468 ? 125 VAL A HG12 1 
ATOM   1925 H HG13 . VAL A 1 125 ? -4.65496  -32.20360 20.47674  1.000 35.42468 ? 125 VAL A HG13 1 
ATOM   1926 H HG21 . VAL A 1 125 ? -7.69138  -32.00790 20.85799  1.000 28.44096 ? 125 VAL A HG21 1 
ATOM   1927 H HG22 . VAL A 1 125 ? -7.79835  -30.48602 20.41534  1.000 28.44096 ? 125 VAL A HG22 1 
ATOM   1928 H HG23 . VAL A 1 125 ? -8.33592  -31.63204 19.45556  1.000 28.44096 ? 125 VAL A HG23 1 
ATOM   1929 N N    . TYR A 1 126 ? -7.35498  -28.38084 18.84259  1.000 22.46488 ? 126 TYR A N    1 
ATOM   1930 C CA   . TYR A 1 126 ? -7.55839  -27.03268 19.35262  1.000 23.70613 ? 126 TYR A CA   1 
ATOM   1931 C C    . TYR A 1 126 ? -9.01807  -26.85554 19.74807  1.000 26.35299 ? 126 TYR A C    1 
ATOM   1932 O O    . TYR A 1 126 ? -9.90324  -27.56969 19.27044  1.000 19.89284 ? 126 TYR A O    1 
ATOM   1933 C CB   . TYR A 1 126 ? -7.15148  -25.97054 18.32193  1.000 23.21903 ? 126 TYR A CB   1 
ATOM   1934 C CG   . TYR A 1 126 ? -7.78971  -26.12266 16.95262  1.000 25.49225 ? 126 TYR A CG   1 
ATOM   1935 C CD1  . TYR A 1 126 ? -9.00752  -25.52334 16.65843  1.000 24.77239 ? 126 TYR A CD1  1 
ATOM   1936 C CD2  . TYR A 1 126 ? -7.16068  -26.84739 15.94678  1.000 28.02607 ? 126 TYR A CD2  1 
ATOM   1937 C CE1  . TYR A 1 126 ? -9.58495  -25.65329 15.40331  1.000 28.46364 ? 126 TYR A CE1  1 
ATOM   1938 C CE2  . TYR A 1 126 ? -7.73078  -26.98077 14.69325  1.000 24.23973 ? 126 TYR A CE2  1 
ATOM   1939 C CZ   . TYR A 1 126 ? -8.94167  -26.38105 14.42732  1.000 27.26516 ? 126 TYR A CZ   1 
ATOM   1940 O OH   . TYR A 1 126 ? -9.51256  -26.51139 13.18019  1.000 33.04023 ? 126 TYR A OH   1 
ATOM   1941 H H    . TYR A 1 126 ? -8.05702  -28.72403 18.48348  1.000 26.98064 ? 126 TYR A H    1 
ATOM   1942 H HA   . TYR A 1 126 ? -7.01574  -26.91200 20.14752  1.000 28.47014 ? 126 TYR A HA   1 
ATOM   1943 H HB2  . TYR A 1 126 ? -7.40363  -25.09873 18.66437  1.000 27.88561 ? 126 TYR A HB2  1 
ATOM   1944 H HB3  . TYR A 1 126 ? -6.19010  -26.01388 18.20040  1.000 27.88561 ? 126 TYR A HB3  1 
ATOM   1945 H HD1  . TYR A 1 126 ? -9.44308  -25.02689 17.31320  1.000 29.74965 ? 126 TYR A HD1  1 
ATOM   1946 H HD2  . TYR A 1 126 ? -6.34063  -27.25044 16.11991  1.000 33.65406 ? 126 TYR A HD2  1 
ATOM   1947 H HE1  . TYR A 1 126 ? -10.40329 -25.25037 15.22201  1.000 34.17914 ? 126 TYR A HE1  1 
ATOM   1948 H HE2  . TYR A 1 126 ? -7.29833  -27.47310 14.03332  1.000 29.11045 ? 126 TYR A HE2  1 
ATOM   1949 H HH   . TYR A 1 126 ? -8.97646  -26.89164 12.65713  1.000 39.67106 ? 126 TYR A HH   1 
ATOM   1950 N N    . GLN A 1 127 ? -9.25721  -25.87780 20.62311  1.000 25.65922 ? 127 GLN A N    1 
ATOM   1951 C CA   . GLN A 1 127 ? -10.58680 -25.60426 21.15302  1.000 24.15022 ? 127 GLN A CA   1 
ATOM   1952 C C    . GLN A 1 127 ? -11.29896 -24.56352 20.29485  1.000 25.60987 ? 127 GLN A C    1 
ATOM   1953 O O    . GLN A 1 127 ? -10.68584 -23.59584 19.83693  1.000 30.43555 ? 127 GLN A O    1 
ATOM   1954 C CB   . GLN A 1 127 ? -10.48716 -25.10838 22.59827  1.000 27.33027 ? 127 GLN A CB   1 
ATOM   1955 C CG   . GLN A 1 127 ? -11.77188 -25.21150 23.39015  1.000 30.76478 ? 127 GLN A CG   1 
ATOM   1956 C CD   . GLN A 1 127 ? -12.05211 -26.62131 23.87192  1.000 28.24865 ? 127 GLN A CD   1 
ATOM   1957 O OE1  . GLN A 1 127 ? -11.49157 -27.59314 23.36161  1.000 31.13124 ? 127 GLN A OE1  1 
ATOM   1958 N NE2  . GLN A 1 127 ? -12.92048 -26.73874 24.86697  1.000 36.67019 ? 127 GLN A NE2  1 
ATOM   1959 H H    . GLN A 1 127 ? -8.65135  -25.34996 20.92957  1.000 30.81384 ? 127 GLN A H    1 
ATOM   1960 H HA   . GLN A 1 127 ? -11.11494 -26.41776 21.13969  1.000 29.00304 ? 127 GLN A HA   1 
ATOM   1961 H HB2  . GLN A 1 127 ? -9.81620  -25.63552 23.05962  1.000 32.81910 ? 127 GLN A HB2  1 
ATOM   1962 H HB3  . GLN A 1 127 ? -10.22506 -24.17454 22.58654  1.000 32.81910 ? 127 GLN A HB3  1 
ATOM   1963 H HG2  . GLN A 1 127 ? -11.71087 -24.63525 24.16804  1.000 36.94051 ? 127 GLN A HG2  1 
ATOM   1964 H HG3  . GLN A 1 127 ? -12.51246 -24.93361 22.82869  1.000 36.94051 ? 127 GLN A HG3  1 
ATOM   1965 H HE21 . GLN A 1 127 ? -13.28894 -26.03721 25.20118  1.000 44.02701 ? 127 GLN A HE21 1 
ATOM   1966 H HE22 . GLN A 1 127 ? -13.11527 -27.51644 25.17817  1.000 44.02701 ? 127 GLN A HE22 1 
ATOM   1967 N N    . CYS A 1 128 ? -12.60301 -24.76309 20.09012  1.000 28.56573 ? 128 CYS A N    1 
ATOM   1968 C CA   . CYS A 1 128 ? -13.42683 -23.85918 19.29910  1.000 27.27564 ? 128 CYS A CA   1 
ATOM   1969 C C    . CYS A 1 128 ? -14.72705 -23.56667 20.02919  1.000 31.02432 ? 128 CYS A C    1 
ATOM   1970 O O    . CYS A 1 128 ? -15.23274 -24.39686 20.78780  1.000 24.73910 ? 128 CYS A O    1 
ATOM   1971 C CB   . CYS A 1 128 ? -13.76171 -24.44684 17.91893  1.000 23.63612 ? 128 CYS A CB   1 
ATOM   1972 S SG   . CYS A 1 128 ? -12.39142 -24.44924 16.74832  1.000 38.38966 ? 128 CYS A SG   1 
ATOM   1973 H H    . CYS A 1 128 ? -13.03954 -25.43217 20.40850  1.000 34.30165 ? 128 CYS A H    1 
ATOM   1974 H HA   . CYS A 1 128 ? -12.94140 -23.02836 19.17659  1.000 32.75355 ? 128 CYS A HA   1 
ATOM   1975 H HB2  . CYS A 1 128 ? -14.04692 -25.36645 18.03671  1.000 28.38612 ? 128 CYS A HB2  1 
ATOM   1976 H HB3  . CYS A 1 128 ? -14.47928 -23.92446 17.52764  1.000 28.38612 ? 128 CYS A HB3  1 
ATOM   1977 H HG   . CYS A 1 128 ? -12.20947 -23.32934 16.35752  1.000 46.09037 ? 128 CYS A HG   1 
ATOM   1978 N N    . ALA A 1 129 ? -15.26675 -22.37780 19.78754  1.000 29.73347 ? 129 ALA A N    1 
ATOM   1979 C CA   . ALA A 1 129 ? -16.61773 -22.04042 20.20278  1.000 24.71496 ? 129 ALA A CA   1 
ATOM   1980 C C    . ALA A 1 129 ? -17.52684 -21.99704 18.98333  1.000 26.09747 ? 129 ALA A C    1 
ATOM   1981 O O    . ALA A 1 129 ? -17.13432 -21.50903 17.91911  1.000 27.94146 ? 129 ALA A O    1 
ATOM   1982 C CB   . ALA A 1 129 ? -16.65669 -20.69569 20.93057  1.000 28.50158 ? 129 ALA A CB   1 
ATOM   1983 H H    . ALA A 1 129 ? -14.86062 -21.74046 19.37710  1.000 35.70294 ? 129 ALA A H    1 
ATOM   1984 H HA   . ALA A 1 129 ? -16.94892 -22.71819 20.81256  1.000 29.68072 ? 129 ALA A HA   1 
ATOM   1985 H HB1  . ALA A 1 129 ? -17.58082 -20.45648 21.10280  1.000 34.22468 ? 129 ALA A HB1  1 
ATOM   1986 H HB2  . ALA A 1 129 ? -16.17413 -20.77585 21.76820  1.000 34.22468 ? 129 ALA A HB2  1 
ATOM   1987 H HB3  . ALA A 1 129 ? -16.23925 -20.02182 20.37152  1.000 34.22468 ? 129 ALA A HB3  1 
ATOM   1988 N N    . MET A 1 130 ? -18.73619 -22.52518 19.14087  1.000 25.72433 ? 130 MET A N    1 
ATOM   1989 C CA   . MET A 1 130 ? -19.78235 -22.37575 18.13582  1.000 25.38990 ? 130 MET A CA   1 
ATOM   1990 C C    . MET A 1 130 ? -20.32840 -20.95571 18.23855  1.000 27.88422 ? 130 MET A C    1 
ATOM   1991 O O    . MET A 1 130 ? -21.05186 -20.63200 19.18723  1.000 26.40523 ? 130 MET A O    1 
ATOM   1992 C CB   . MET A 1 130 ? -20.87615 -23.41699 18.35796  1.000 22.85670 ? 130 MET A CB   1 
ATOM   1993 C CG   . MET A 1 130 ? -22.03931 -23.33354 17.37889  1.000 27.18016 ? 130 MET A CG   1 
ATOM   1994 S SD   . MET A 1 130 ? -21.53658 -23.59183 15.66953  1.000 29.27168 ? 130 MET A SD   1 
ATOM   1995 C CE   . MET A 1 130 ? -20.99612 -25.29801 15.72600  1.000 24.14336 ? 130 MET A CE   1 
ATOM   1996 H H    . MET A 1 130 ? -18.97828 -22.97997 19.82946  1.000 30.89197 ? 130 MET A H    1 
ATOM   1997 H HA   . MET A 1 130 ? -19.41826 -22.51964 17.24833  1.000 30.49066 ? 130 MET A HA   1 
ATOM   1998 H HB2  . MET A 1 130 ? -20.48377 -24.29985 18.27145  1.000 27.45082 ? 130 MET A HB2  1 
ATOM   1999 H HB3  . MET A 1 130 ? -21.23651 -23.30015 19.25093  1.000 27.45082 ? 130 MET A HB3  1 
ATOM   2000 H HG2  . MET A 1 130 ? -22.69166 -24.01480 17.60521  1.000 32.63897 ? 130 MET A HG2  1 
ATOM   2001 H HG3  . MET A 1 130 ? -22.44274 -22.45372 17.44254  1.000 32.63897 ? 130 MET A HG3  1 
ATOM   2002 H HE1  . MET A 1 130 ? -21.73548 -25.85399 16.01778  1.000 28.99481 ? 130 MET A HE1  1 
ATOM   2003 H HE2  . MET A 1 130 ? -20.70905 -25.56784 14.83962  1.000 28.99481 ? 130 MET A HE2  1 
ATOM   2004 H HE3  . MET A 1 130 ? -20.25787 -25.37492 16.35049  1.000 28.99481 ? 130 MET A HE3  1 
ATOM   2005 N N    . ARG A 1 131 ? -19.96992 -20.09767 17.27628  1.000 25.25569 ? 131 ARG A N    1 
ATOM   2006 C CA   . ARG A 1 131 ? -20.36854 -18.69954 17.34545  1.000 25.77533 ? 131 ARG A CA   1 
ATOM   2007 C C    . ARG A 1 131 ? -21.89221 -18.59083 17.37308  1.000 26.85415 ? 131 ARG A C    1 
ATOM   2008 O O    . ARG A 1 131 ? -22.60046 -19.51846 16.97008  1.000 24.72176 ? 131 ARG A O    1 
ATOM   2009 C CB   . ARG A 1 131 ? -19.81859 -17.90863 16.15563  1.000 23.11349 ? 131 ARG A CB   1 
ATOM   2010 C CG   . ARG A 1 131 ? -18.31237 -18.01663 15.93129  1.000 30.93735 ? 131 ARG A CG   1 
ATOM   2011 C CD   . ARG A 1 131 ? -17.49321 -17.52368 17.10199  1.000 29.99882 ? 131 ARG A CD   1 
ATOM   2012 N NE   . ARG A 1 131 ? -17.91625 -16.21078 17.56978  1.000 31.57578 ? 131 ARG A NE   1 
ATOM   2013 C CZ   . ARG A 1 131 ? -17.47509 -15.64737 18.68513  1.000 29.43973 ? 131 ARG A CZ   1 
ATOM   2014 N NH1  . ARG A 1 131 ? -16.57676 -16.24555 19.45195  1.000 22.35965 ? 131 ARG A NH1  1 
ATOM   2015 N NH2  . ARG A 1 131 ? -17.95071 -14.45850 19.04334  1.000 28.16500 ? 131 ARG A NH2  1 
ATOM   2016 H H    . ARG A 1 131 ? -19.50220 -20.30282 16.58436  1.000 30.32960 ? 131 ARG A H    1 
ATOM   2017 H HA   . ARG A 1 131 ? -20.00755 -18.30882 18.15658  1.000 30.95318 ? 131 ARG A HA   1 
ATOM   2018 H HB2  . ARG A 1 131 ? -20.25369 -18.22859 15.34989  1.000 27.75897 ? 131 ARG A HB2  1 
ATOM   2019 H HB3  . ARG A 1 131 ? -20.02303 -16.97040 16.29286  1.000 27.75897 ? 131 ARG A HB3  1 
ATOM   2020 H HG2  . ARG A 1 131 ? -18.08350 -18.94702 15.77996  1.000 37.14760 ? 131 ARG A HG2  1 
ATOM   2021 H HG3  . ARG A 1 131 ? -18.07160 -17.48545 15.15620  1.000 37.14760 ? 131 ARG A HG3  1 
ATOM   2022 H HD2  . ARG A 1 131 ? -17.58505 -18.14856 17.83818  1.000 36.02136 ? 131 ARG A HD2  1 
ATOM   2023 H HD3  . ARG A 1 131 ? -16.56312 -17.46140 16.83376  1.000 36.02136 ? 131 ARG A HD3  1 
ATOM   2024 H HE   . ARG A 1 131 ? -18.48568 -15.77574 17.09430  1.000 37.91372 ? 131 ARG A HE   1 
ATOM   2025 H HH11 . ARG A 1 131 ? -16.26684 -17.01643 19.22994  1.000 26.85435 ? 131 ARG A HH11 1 
ATOM   2026 H HH12 . ARG A 1 131 ? -16.30314 -15.86322 20.17206  1.000 26.85435 ? 131 ARG A HH12 1 
ATOM   2027 H HH21 . ARG A 1 131 ? -18.53742 -14.06463 18.55321  1.000 33.82078 ? 131 ARG A HH21 1 
ATOM   2028 H HH22 . ARG A 1 131 ? -17.67161 -14.08342 19.76516  1.000 33.82078 ? 131 ARG A HH22 1 
ATOM   2029 N N    . PRO A 1 132 ? -22.42177 -17.46323 17.85378  1.000 25.25109 ? 132 PRO A N    1 
ATOM   2030 C CA   . PRO A 1 132 ? -23.87839 -17.26851 17.79258  1.000 25.86367 ? 132 PRO A CA   1 
ATOM   2031 C C    . PRO A 1 132 ? -24.43556 -17.33169 16.38233  1.000 24.89994 ? 132 PRO A C    1 
ATOM   2032 O O    . PRO A 1 132 ? -25.60686 -17.69118 16.20879  1.000 27.82929 ? 132 PRO A O    1 
ATOM   2033 C CB   . PRO A 1 132 ? -24.06736 -15.88174 18.42294  1.000 27.46393 ? 132 PRO A CB   1 
ATOM   2034 C CG   . PRO A 1 132 ? -22.91548 -15.74717 19.35014  1.000 28.76700 ? 132 PRO A CG   1 
ATOM   2035 C CD   . PRO A 1 132 ? -21.76365 -16.39592 18.62823  1.000 28.18293 ? 132 PRO A CD   1 
ATOM   2036 H HA   . PRO A 1 132 ? -24.32791 -17.93142 18.33973  1.000 31.05918 ? 132 PRO A HA   1 
ATOM   2037 H HB2  . PRO A 1 132 ? -24.04643 -15.19705 17.73617  1.000 32.97949 ? 132 PRO A HB2  1 
ATOM   2038 H HB3  . PRO A 1 132 ? -24.90966 -15.84488 18.90260  1.000 32.97949 ? 132 PRO A HB3  1 
ATOM   2039 H HG2  . PRO A 1 132 ? -22.73490 -14.80951 19.52067  1.000 34.54318 ? 132 PRO A HG2  1 
ATOM   2040 H HG3  . PRO A 1 132 ? -23.10554 -16.20537 20.18371  1.000 34.54318 ? 132 PRO A HG3  1 
ATOM   2041 H HD2  . PRO A 1 132 ? -21.32171 -15.76308 18.04078  1.000 33.84229 ? 132 PRO A HD2  1 
ATOM   2042 H HD3  . PRO A 1 132 ? -21.12488 -16.76691 19.25692  1.000 33.84229 ? 132 PRO A HD3  1 
ATOM   2043 N N    . ASN A 1 133 ? -23.63876 -16.99578 15.36659  1.000 23.00157 ? 133 ASN A N    1 
ATOM   2044 C CA   . ASN A 1 133 ? -24.05748 -17.12663 13.97770  1.000 24.48024 ? 133 ASN A CA   1 
ATOM   2045 C C    . ASN A 1 133 ? -23.67857 -18.48020 13.38192  1.000 24.65484 ? 133 ASN A C    1 
ATOM   2046 O O    . ASN A 1 133 ? -23.61705 -18.61444 12.15470  1.000 24.46762 ? 133 ASN A O    1 
ATOM   2047 C CB   . ASN A 1 133 ? -23.46690 -15.99253 13.13764  1.000 25.00965 ? 133 ASN A CB   1 
ATOM   2048 C CG   . ASN A 1 133 ? -21.96157 -16.09349 12.99259  1.000 28.48574 ? 133 ASN A CG   1 
ATOM   2049 O OD1  . ASN A 1 133 ? -21.31230 -16.89230 13.66456  1.000 25.17254 ? 133 ASN A OD1  1 
ATOM   2050 N ND2  . ASN A 1 133 ? -21.39825 -15.27504 12.11516  1.000 26.76664 ? 133 ASN A ND2  1 
ATOM   2051 H H    . ASN A 1 133 ? -22.84205 -16.68629 15.46182  1.000 27.62467 ? 133 ASN A H    1 
ATOM   2052 H HA   . ASN A 1 133 ? -25.02337 -17.04612 13.93930  1.000 29.39906 ? 133 ASN A HA   1 
ATOM   2053 H HB2  . ASN A 1 133 ? -23.85642 -16.02088 12.24974  1.000 30.03436 ? 133 ASN A HB2  1 
ATOM   2054 H HB3  . ASN A 1 133 ? -23.67116 -15.14485 13.56262  1.000 30.03436 ? 133 ASN A HB3  1 
ATOM   2055 H HD21 . ASN A 1 133 ? -20.54681 -15.29297 11.99546  1.000 32.14274 ? 133 ASN A HD21 1 
ATOM   2056 H HD22 . ASN A 1 133 ? -21.88422 -14.72610 11.66559  1.000 32.14274 ? 133 ASN A HD22 1 
ATOM   2057 N N    . PHE A 1 134 ? -23.39589 -19.46908 14.23041  1.000 21.74620 ? 134 PHE A N    1 
ATOM   2058 C CA   . PHE A 1 134 ? -23.20035 -20.86046 13.81594  1.000 23.86243 ? 134 PHE A CA   1 
ATOM   2059 C C    . PHE A 1 134 ? -22.02201 -21.01746 12.85598  1.000 24.58691 ? 134 PHE A C    1 
ATOM   2060 O O    . PHE A 1 134 ? -22.06629 -21.81119 11.91297  1.000 30.00363 ? 134 PHE A O    1 
ATOM   2061 C CB   . PHE A 1 134 ? -24.48015 -21.43690 13.20568  1.000 24.86226 ? 134 PHE A CB   1 
ATOM   2062 C CG   . PHE A 1 134 ? -25.58420 -21.63890 14.20155  1.000 26.12120 ? 134 PHE A CG   1 
ATOM   2063 C CD1  . PHE A 1 134 ? -25.49664 -22.63838 15.15894  1.000 25.68957 ? 134 PHE A CD1  1 
ATOM   2064 C CD2  . PHE A 1 134 ? -26.70723 -20.83075 14.18277  1.000 26.13104 ? 134 PHE A CD2  1 
ATOM   2065 C CE1  . PHE A 1 134 ? -26.51106 -22.82883 16.07727  1.000 29.84537 ? 134 PHE A CE1  1 
ATOM   2066 C CE2  . PHE A 1 134 ? -27.72410 -21.01538 15.09612  1.000 28.25594 ? 134 PHE A CE2  1 
ATOM   2067 C CZ   . PHE A 1 134 ? -27.62703 -22.01645 16.04589  1.000 31.84298 ? 134 PHE A CZ   1 
ATOM   2068 H H    . PHE A 1 134 ? -23.30922 -19.35685 15.07863  1.000 26.11821 ? 134 PHE A H    1 
ATOM   2069 H HA   . PHE A 1 134 ? -22.98217 -21.37538 14.60851  1.000 28.65770 ? 134 PHE A HA   1 
ATOM   2070 H HB2  . PHE A 1 134 ? -24.80345 -20.82687 12.52432  1.000 29.85749 ? 134 PHE A HB2  1 
ATOM   2071 H HB3  . PHE A 1 134 ? -24.27663 -22.29874 12.80981  1.000 29.85749 ? 134 PHE A HB3  1 
ATOM   2072 H HD1  . PHE A 1 134 ? -24.74608 -23.18699 15.18308  1.000 30.85026 ? 134 PHE A HD1  1 
ATOM   2073 H HD2  . PHE A 1 134 ? -26.77716 -20.15549 13.54714  1.000 31.38002 ? 134 PHE A HD2  1 
ATOM   2074 H HE1  . PHE A 1 134 ? -26.44243 -23.50239 16.71485  1.000 35.83722 ? 134 PHE A HE1  1 
ATOM   2075 H HE2  . PHE A 1 134 ? -28.47486 -20.46698 15.07346  1.000 33.92990 ? 134 PHE A HE2  1 
ATOM   2076 H HZ   . PHE A 1 134 ? -28.31217 -22.14202 16.66210  1.000 38.23436 ? 134 PHE A HZ   1 
ATOM   2077 N N    . THR A 1 135 ? -20.95360 -20.26830 13.10736  1.000 26.10138 ? 135 THR A N    1 
ATOM   2078 C CA   . THR A 1 135 ? -19.65792 -20.49423 12.48457  1.000 22.82612 ? 135 THR A CA   1 
ATOM   2079 C C    . THR A 1 135 ? -18.64692 -20.82160 13.57511  1.000 24.44782 ? 135 THR A C    1 
ATOM   2080 O O    . THR A 1 135 ? -18.92846 -20.69477 14.76877  1.000 25.96265 ? 135 THR A O    1 
ATOM   2081 C CB   . THR A 1 135 ? -19.18726 -19.27121 11.68375  1.000 24.42618 ? 135 THR A CB   1 
ATOM   2082 O OG1  . THR A 1 135 ? -18.97832 -18.15953 12.56633  1.000 25.73063 ? 135 THR A OG1  1 
ATOM   2083 C CG2  . THR A 1 135 ? -20.20797 -18.89252 10.62040  1.000 25.61269 ? 135 THR A CG2  1 
ATOM   2084 H H    . THR A 1 135 ? -20.95677 -19.60306 13.65238  1.000 31.34443 ? 135 THR A H    1 
ATOM   2085 H HA   . THR A 1 135 ? -19.72296 -21.23917 11.86672  1.000 27.41412 ? 135 THR A HA   1 
ATOM   2086 H HB   . THR A 1 135 ? -18.35310 -19.48621 11.23780  1.000 29.33419 ? 135 THR A HB   1 
ATOM   2087 H HG1  . THR A 1 135 ? -19.70899 -17.91976 12.90432  1.000 30.89953 ? 135 THR A HG1  1 
ATOM   2088 H HG21 . THR A 1 135 ? -20.05751 -17.98064 10.32592  1.000 30.75800 ? 135 THR A HG21 1 
ATOM   2089 H HG22 . THR A 1 135 ? -20.12863 -19.48674 9.85783   1.000 30.75800 ? 135 THR A HG22 1 
ATOM   2090 H HG23 . THR A 1 135 ? -21.10531 -18.96254 10.98203  1.000 30.75800 ? 135 THR A HG23 1 
ATOM   2091 N N    . ILE A 1 136 ? -17.45880 -21.25694 13.16065  1.000 24.23397 ? 136 ILE A N    1 
ATOM   2092 C CA   . ILE A 1 136 ? -16.34304 -21.42947 14.08080  1.000 20.79802 ? 136 ILE A CA   1 
ATOM   2093 C C    . ILE A 1 136 ? -15.09338 -20.87492 13.41751  1.000 20.58930 ? 136 ILE A C    1 
ATOM   2094 O O    . ILE A 1 136 ? -14.98016 -20.83865 12.18821  1.000 22.50829 ? 136 ILE A O    1 
ATOM   2095 C CB   . ILE A 1 136 ? -16.12564 -22.90282 14.51600  1.000 24.11845 ? 136 ILE A CB   1 
ATOM   2096 C CG1  . ILE A 1 136 ? -15.63851 -23.77144 13.35283  1.000 21.80162 ? 136 ILE A CG1  1 
ATOM   2097 C CG2  . ILE A 1 136 ? -17.40533 -23.47992 15.10462  1.000 24.27133 ? 136 ILE A CG2  1 
ATOM   2098 C CD1  . ILE A 1 136 ? -15.35629 -25.21609 13.75791  1.000 24.33714 ? 136 ILE A CD1  1 
ATOM   2099 H H    . ILE A 1 136 ? -17.27577 -21.45965 12.34517  1.000 29.10354 ? 136 ILE A H    1 
ATOM   2100 H HA   . ILE A 1 136 ? -16.52696 -20.92221 14.88688  1.000 24.98040 ? 136 ILE A HA   1 
ATOM   2101 H HB   . ILE A 1 136 ? -15.43400 -22.90327 15.19609  1.000 28.96491 ? 136 ILE A HB   1 
ATOM   2102 H HG12 . ILE A 1 136 ? -16.31989 -23.78277 12.66255  1.000 26.18472 ? 136 ILE A HG12 1 
ATOM   2103 H HG13 . ILE A 1 136 ? -14.81682 -23.39403 13.00173  1.000 26.18472 ? 136 ILE A HG13 1 
ATOM   2104 H HG21 . ILE A 1 136 ? -17.97538 -23.78597 14.38193  1.000 29.14838 ? 136 ILE A HG21 1 
ATOM   2105 H HG22 . ILE A 1 136 ? -17.17877 -24.22353 15.68480  1.000 29.14838 ? 136 ILE A HG22 1 
ATOM   2106 H HG23 . ILE A 1 136 ? -17.85831 -22.78943 15.61348  1.000 29.14838 ? 136 ILE A HG23 1 
ATOM   2107 H HD11 . ILE A 1 136 ? -15.03092 -25.70307 12.98468  1.000 29.22735 ? 136 ILE A HD11 1 
ATOM   2108 H HD12 . ILE A 1 136 ? -14.68585 -25.22229 14.45889  1.000 29.22735 ? 136 ILE A HD12 1 
ATOM   2109 H HD13 . ILE A 1 136 ? -16.17696 -25.61940 14.08154  1.000 29.22735 ? 136 ILE A HD13 1 
ATOM   2110 N N    . LYS A 1 137 ? -14.15725 -20.43109 14.24775  1.000 24.49752 ? 137 LYS A N    1 
ATOM   2111 C CA   . LYS A 1 137 ? -12.89856 -19.84997 13.78888  1.000 27.72364 ? 137 LYS A CA   1 
ATOM   2112 C C    . LYS A 1 137 ? -11.85146 -20.94654 13.92889  1.000 26.15389 ? 137 LYS A C    1 
ATOM   2113 O O    . LYS A 1 137 ? -11.21308 -21.10119 14.97107  1.000 26.02953 ? 137 LYS A O    1 
ATOM   2114 C CB   . LYS A 1 137 ? -12.54753 -18.60190 14.58692  1.000 29.84890 ? 137 LYS A CB   1 
ATOM   2115 C CG   . LYS A 1 137 ? -13.66496 -17.56422 14.60798  1.000 35.34301 ? 137 LYS A CG   1 
ATOM   2116 C CD   . LYS A 1 137 ? -13.14520 -16.19143 14.99932  1.000 43.61012 ? 137 LYS A CD   1 
ATOM   2117 C CE   . LYS A 1 137 ? -14.26901 -15.27738 15.46591  1.000 43.43683 ? 137 LYS A CE   1 
ATOM   2118 N NZ   . LYS A 1 137 ? -15.35688 -15.14756 14.45584  1.000 45.89814 ? 137 LYS A NZ   1 
ATOM   2119 H H    . LYS A 1 137 ? -14.22881 -20.45588 15.10441  1.000 29.41981 ? 137 LYS A H    1 
ATOM   2120 H HA   . LYS A 1 137 ? -12.96416 -19.58663 12.85762  1.000 33.29115 ? 137 LYS A HA   1 
ATOM   2121 H HB2  . LYS A 1 137 ? -12.36158 -18.85814 15.50380  1.000 35.84145 ? 137 LYS A HB2  1 
ATOM   2122 H HB3  . LYS A 1 137 ? -11.76388 -18.18791 14.19271  1.000 35.84145 ? 137 LYS A HB3  1 
ATOM   2123 H HG2  . LYS A 1 137 ? -14.05991 -17.49979 13.72437  1.000 42.43439 ? 137 LYS A HG2  1 
ATOM   2124 H HG3  . LYS A 1 137 ? -14.33812 -17.83041 15.25365  1.000 42.43439 ? 137 LYS A HG3  1 
ATOM   2125 H HD2  . LYS A 1 137 ? -12.50790 -16.28459 15.72463  1.000 52.35492 ? 137 LYS A HD2  1 
ATOM   2126 H HD3  . LYS A 1 137 ? -12.71707 -15.77997 14.23231  1.000 52.35492 ? 137 LYS A HD3  1 
ATOM   2127 H HE2  . LYS A 1 137 ? -14.65523 -15.63925 16.27880  1.000 52.14697 ? 137 LYS A HE2  1 
ATOM   2128 H HE3  . LYS A 1 137 ? -13.90872 -14.39279 15.63500  1.000 52.14697 ? 137 LYS A HE3  1 
ATOM   2129 H HZ1  . LYS A 1 137 ? -15.99230 -14.60418 14.76095  1.000 55.10055 ? 137 LYS A HZ1  1 
ATOM   2130 H HZ2  . LYS A 1 137 ? -15.03052 -14.81356 13.69819  1.000 55.10055 ? 137 LYS A HZ2  1 
ATOM   2131 H HZ3  . LYS A 1 137 ? -15.71450 -15.94537 14.28938  1.000 55.10055 ? 137 LYS A HZ3  1 
ATOM   2132 N N    . GLY A 1 138 ? -11.68587 -21.72116 12.85984  1.000 26.91120 ? 138 GLY A N    1 
ATOM   2133 C CA   . GLY A 1 138 ? -10.87211 -22.91000 12.88310  1.000 25.45499 ? 138 GLY A CA   1 
ATOM   2134 C C    . GLY A 1 138 ? -9.57865  -22.75732 12.10915  1.000 28.17632 ? 138 GLY A C    1 
ATOM   2135 O O    . GLY A 1 138 ? -9.16670  -21.66093 11.72291  1.000 26.96910 ? 138 GLY A O    1 
ATOM   2136 H H    . GLY A 1 138 ? -12.04786 -21.56653 12.09521  1.000 32.31622 ? 138 GLY A H    1 
ATOM   2137 H HA2  . GLY A 1 138 ? -10.65147 -23.12708 13.80239  1.000 30.56877 ? 138 GLY A HA2  1 
ATOM   2138 H HA3  . GLY A 1 138 ? -11.37188 -23.64576 12.49608  1.000 30.56877 ? 138 GLY A HA3  1 
ATOM   2139 N N    . SER A 1 139 ? -8.92359  -23.89798 11.90692  1.000 21.59258 ? 139 SER A N    1 
ATOM   2140 C CA   . SER A 1 139 ? -7.73707  -24.01046 11.06102  1.000 22.41046 ? 139 SER A CA   1 
ATOM   2141 C C    . SER A 1 139 ? -7.95169  -25.25756 10.21046  1.000 23.38798 ? 139 SER A C    1 
ATOM   2142 O O    . SER A 1 139 ? -7.78063  -26.37966 10.69692  1.000 24.91308 ? 139 SER A O    1 
ATOM   2143 C CB   . SER A 1 139 ? -6.45820  -24.10550 11.88320  1.000 26.86368 ? 139 SER A CB   1 
ATOM   2144 O OG   . SER A 1 139 ? -5.32275  -24.10571 11.03810  1.000 28.78352 ? 139 SER A OG   1 
ATOM   2145 H H    . SER A 1 139 ? -9.15537  -24.64650 12.26132  1.000 25.93387 ? 139 SER A H    1 
ATOM   2146 H HA   . SER A 1 139 ? -7.65224  -23.22941 10.49210  1.000 26.91533 ? 139 SER A HA   1 
ATOM   2147 H HB2  . SER A 1 139 ? -6.40829  -23.34309 12.48080  1.000 32.25919 ? 139 SER A HB2  1 
ATOM   2148 H HB3  . SER A 1 139 ? -6.47165  -24.92872 12.39607  1.000 32.25919 ? 139 SER A HB3  1 
ATOM   2149 H HG   . SER A 1 139 ? -5.31862  -23.41348 10.56229  1.000 34.56301 ? 139 SER A HG   1 
ATOM   2150 N N    . PHE A 1 140 ? -8.33640  -25.05506 8.95072   1.000 22.88994 ? 140 PHE A N    1 
ATOM   2151 C CA   . PHE A 1 140 ? -8.72379  -26.13951 8.05925   1.000 23.28090 ? 140 PHE A CA   1 
ATOM   2152 C C    . PHE A 1 140 ? -8.15709  -25.89039 6.67225   1.000 24.71117 ? 140 PHE A C    1 
ATOM   2153 O O    . PHE A 1 140 ? -8.35273  -24.81206 6.10462   1.000 21.23628 ? 140 PHE A O    1 
ATOM   2154 C CB   . PHE A 1 140 ? -10.24806 -26.26362 7.96210   1.000 22.25118 ? 140 PHE A CB   1 
ATOM   2155 C CG   . PHE A 1 140 ? -10.91350 -26.66219 9.24784   1.000 20.54309 ? 140 PHE A CG   1 
ATOM   2156 C CD1  . PHE A 1 140 ? -10.85534 -27.97047 9.69542   1.000 24.27542 ? 140 PHE A CD1  1 
ATOM   2157 C CD2  . PHE A 1 140 ? -11.59884 -25.73112 10.00707  1.000 26.16969 ? 140 PHE A CD2  1 
ATOM   2158 C CE1  . PHE A 1 140 ? -11.46869 -28.34251 10.87549  1.000 23.86589 ? 140 PHE A CE1  1 
ATOM   2159 C CE2  . PHE A 1 140 ? -12.21518 -26.09930 11.18832  1.000 25.32172 ? 140 PHE A CE2  1 
ATOM   2160 C CZ   . PHE A 1 140 ? -12.15002 -27.40830 11.62013  1.000 22.58694 ? 140 PHE A CZ   1 
ATOM   2161 H H    . PHE A 1 140 ? -8.38134  -24.27878 8.58333   1.000 27.49070 ? 140 PHE A H    1 
ATOM   2162 H HA   . PHE A 1 140 ? -8.35602  -26.96907 8.40201   1.000 27.95986 ? 140 PHE A HA   1 
ATOM   2163 H HB2  . PHE A 1 140 ? -10.61319 -25.40559 7.69497   1.000 26.72420 ? 140 PHE A HB2  1 
ATOM   2164 H HB3  . PHE A 1 140 ? -10.46318 -26.93700 7.29789   1.000 26.72420 ? 140 PHE A HB3  1 
ATOM   2165 H HD1  . PHE A 1 140 ? -10.39752 -28.60700 9.19528   1.000 29.15329 ? 140 PHE A HD1  1 
ATOM   2166 H HD2  . PHE A 1 140 ? -11.64550 -24.84785 9.71974   1.000 31.42640 ? 140 PHE A HD2  1 
ATOM   2167 H HE1  . PHE A 1 140 ? -11.42102 -29.22450 11.16654  1.000 28.66184 ? 140 PHE A HE1  1 
ATOM   2168 H HE2  . PHE A 1 140 ? -12.67331 -25.46542 11.69154  1.000 30.40884 ? 140 PHE A HE2  1 
ATOM   2169 H HZ   . PHE A 1 140 ? -12.56614 -27.65836 12.41336  1.000 27.12711 ? 140 PHE A HZ   1 
ATOM   2170 N N    . LEU A 1 141 ? -7.47853  -26.89192 6.12738   1.000 27.94941 ? 141 LEU A N    1 
ATOM   2171 C CA   . LEU A 1 141 ? -6.97501  -26.87657 4.76382   1.000 26.38861 ? 141 LEU A CA   1 
ATOM   2172 C C    . LEU A 1 141 ? -7.75361  -27.89168 3.93382   1.000 27.68035 ? 141 LEU A C    1 
ATOM   2173 O O    . LEU A 1 141 ? -8.59451  -28.63606 4.44636   1.000 26.13586 ? 141 LEU A O    1 
ATOM   2174 C CB   . LEU A 1 141 ? -5.47465  -27.17536 4.74703   1.000 26.31999 ? 141 LEU A CB   1 
ATOM   2175 C CG   . LEU A 1 141 ? -4.60792  -26.22937 5.58299   1.000 32.46883 ? 141 LEU A CG   1 
ATOM   2176 C CD1  . LEU A 1 141 ? -3.23408  -26.83199 5.83226   1.000 40.58372 ? 141 LEU A CD1  1 
ATOM   2177 C CD2  . LEU A 1 141 ? -4.48098  -24.86907 4.90553   1.000 33.23076 ? 141 LEU A CD2  1 
ATOM   2178 H H    . LEU A 1 141 ? -7.29092  -27.61919 6.54629   1.000 33.56207 ? 141 LEU A H    1 
ATOM   2179 H HA   . LEU A 1 141 ? -7.10739  -25.99654 4.37791   1.000 31.68911 ? 141 LEU A HA   1 
ATOM   2180 H HB2  . LEU A 1 141 ? -5.33857  -28.07243 5.09003   1.000 31.60676 ? 141 LEU A HB2  1 
ATOM   2181 H HB3  . LEU A 1 141 ? -5.16299  -27.11994 3.83013   1.000 31.60676 ? 141 LEU A HB3  1 
ATOM   2182 H HG   . LEU A 1 141 ? -5.03679  -26.09676 6.44286   1.000 38.98537 ? 141 LEU A HG   1 
ATOM   2183 H HD11 . LEU A 1 141 ? -3.25347  -27.32857 6.66528   1.000 48.72324 ? 141 LEU A HD11 1 
ATOM   2184 H HD12 . LEU A 1 141 ? -3.01183  -27.42588 5.09823   1.000 48.72324 ? 141 LEU A HD12 1 
ATOM   2185 H HD13 . LEU A 1 141 ? -2.58107  -26.11693 5.88855   1.000 48.72324 ? 141 LEU A HD13 1 
ATOM   2186 H HD21 . LEU A 1 141 ? -3.84834  -24.93863 4.17352   1.000 39.89969 ? 141 LEU A HD21 1 
ATOM   2187 H HD22 . LEU A 1 141 ? -5.35012  -24.60236 4.56734   1.000 39.89969 ? 141 LEU A HD22 1 
ATOM   2188 H HD23 . LEU A 1 141 ? -4.16562  -24.22110 5.55483   1.000 39.89969 ? 141 LEU A HD23 1 
ATOM   2189 N N    . ASN A 1 142 ? -7.47173  -27.92078 2.63424   1.000 30.07910 ? 142 ASN A N    1 
ATOM   2190 C CA   . ASN A 1 142 ? -8.09933  -28.91973 1.78320   1.000 27.97844 ? 142 ASN A CA   1 
ATOM   2191 C C    . ASN A 1 142 ? -7.73411  -30.30990 2.28818   1.000 28.38598 ? 142 ASN A C    1 
ATOM   2192 O O    . ASN A 1 142 ? -6.59697  -30.56186 2.69639   1.000 26.53406 ? 142 ASN A O    1 
ATOM   2193 C CB   . ASN A 1 142 ? -7.66896  -28.73209 0.32874   1.000 38.64473 ? 142 ASN A CB   1 
ATOM   2194 C CG   . ASN A 1 142 ? -8.80332  -28.98353 -0.64469  1.000 48.87601 ? 142 ASN A CG   1 
ATOM   2195 O OD1  . ASN A 1 142 ? -9.79359  -28.24982 -0.66578  1.000 52.64231 ? 142 ASN A OD1  1 
ATOM   2196 N ND2  . ASN A 1 142 ? -8.66595  -30.02315 -1.45713  1.000 49.58508 ? 142 ASN A ND2  1 
ATOM   2197 H H    . ASN A 1 142 ? -6.93280  -27.38494 2.23172   1.000 36.11770 ? 142 ASN A H    1 
ATOM   2198 H HA   . ASN A 1 142 ? -9.06435  -28.82434 1.80613   1.000 33.59691 ? 142 ASN A HA   1 
ATOM   2199 H HB2  . ASN A 1 142 ? -7.36045  -27.82099 0.20372   1.000 46.39645 ? 142 ASN A HB2  1 
ATOM   2200 H HB3  . ASN A 1 142 ? -6.95377  -29.35527 0.12611   1.000 46.39645 ? 142 ASN A HB3  1 
ATOM   2201 H HD21 . ASN A 1 142 ? -9.28251  -30.20745 -2.02764  1.000 59.52487 ? 142 ASN A HD21 1 
ATOM   2202 H HD22 . ASN A 1 142 ? -7.96033  -30.51282 -1.41332  1.000 59.52487 ? 142 ASN A HD22 1 
ATOM   2203 N N    . GLY A 1 143 ? -8.71848  -31.20649 2.29189   1.000 24.27746 ? 143 GLY A N    1 
ATOM   2204 C CA   . GLY A 1 143 ? -8.54752  -32.53162 2.84312   1.000 27.89534 ? 143 GLY A CA   1 
ATOM   2205 C C    . GLY A 1 143 ? -8.93122  -32.67343 4.30217   1.000 22.37318 ? 143 GLY A C    1 
ATOM   2206 O O    . GLY A 1 143 ? -8.94098  -33.79958 4.81465   1.000 22.63892 ? 143 GLY A O    1 
ATOM   2207 H H    . GLY A 1 143 ? -9.50423  -31.06116 1.97397   1.000 29.15573 ? 143 GLY A H    1 
ATOM   2208 H HA2  . GLY A 1 143 ? -9.09169  -33.15194 2.33325   1.000 33.49719 ? 143 GLY A HA2  1 
ATOM   2209 H HA3  . GLY A 1 143 ? -7.61517  -32.78508 2.75721   1.000 33.49719 ? 143 GLY A HA3  1 
ATOM   2210 N N    . SER A 1 144 ? -9.25232  -31.57532 4.98667   1.000 23.79850 ? 144 SER A N    1 
ATOM   2211 C CA   . SER A 1 144 ? -9.58386  -31.62207 6.40568   1.000 23.73897 ? 144 SER A CA   1 
ATOM   2212 C C    . SER A 1 144 ? -11.04309 -31.95689 6.67758   1.000 23.55955 ? 144 SER A C    1 
ATOM   2213 O O    . SER A 1 144 ? -11.39757 -32.19449 7.83752   1.000 23.37969 ? 144 SER A O    1 
ATOM   2214 C CB   . SER A 1 144 ? -9.26352  -30.28256 7.07485   1.000 22.41502 ? 144 SER A CB   1 
ATOM   2215 O OG   . SER A 1 144 ? -10.06865 -29.24133 6.55054   1.000 23.85928 ? 144 SER A OG   1 
ATOM   2216 H H    . SER A 1 144 ? -9.28497  -30.78578 4.64732   1.000 28.58097 ? 144 SER A H    1 
ATOM   2217 H HA   . SER A 1 144 ? -9.03328  -32.31029 6.81077   1.000 28.50954 ? 144 SER A HA   1 
ATOM   2218 H HB2  . SER A 1 144 ? -9.43027  -30.35937 8.02732   1.000 26.92080 ? 144 SER A HB2  1 
ATOM   2219 H HB3  . SER A 1 144 ? -8.33072  -30.06794 6.91760   1.000 26.92080 ? 144 SER A HB3  1 
ATOM   2220 H HG   . SER A 1 144 ? -9.70505  -28.91280 5.86829   1.000 28.65391 ? 144 SER A HG   1 
ATOM   2221 N N    . CYS A 1 145 ? -11.89616 -31.97242 5.65844   1.000 21.41875 ? 145 CYS A N    1 
ATOM   2222 C CA   . CYS A 1 145 ? -13.29648 -32.29942 5.88434   1.000 20.55295 ? 145 CYS A CA   1 
ATOM   2223 C C    . CYS A 1 145 ? -13.42795 -33.70582 6.45171   1.000 24.49511 ? 145 CYS A C    1 
ATOM   2224 O O    . CYS A 1 145 ? -12.65826 -34.60712 6.11349   1.000 21.37077 ? 145 CYS A O    1 
ATOM   2225 C CB   . CYS A 1 145 ? -14.08045 -32.15347 4.58708   1.000 20.42718 ? 145 CYS A CB   1 
ATOM   2226 S SG   . CYS A 1 145 ? -14.32767 -30.41832 4.18323   1.000 24.11573 ? 145 CYS A SG   1 
ATOM   2227 H H    . CYS A 1 145 ? -11.69213 -31.80020 4.84093   1.000 25.72528 ? 145 CYS A H    1 
ATOM   2228 H HA   . CYS A 1 145 ? -13.68045 -31.68570 6.52995   1.000 24.68632 ? 145 CYS A HA   1 
ATOM   2229 H HB2  . CYS A 1 145 ? -13.58857 -32.57198 3.86334   1.000 24.53539 ? 145 CYS A HB2  1 
ATOM   2230 H HB3  . CYS A 1 145 ? -14.94878 -32.57453 4.68507   1.000 24.53539 ? 145 CYS A HB3  1 
ATOM   2231 N N    . GLY A 1 146 ? -14.39815 -33.88171 7.34373   1.000 23.62612 ? 146 GLY A N    1 
ATOM   2232 C CA   . GLY A 1 146 ? -14.53510 -35.09321 8.10743   1.000 23.80229 ? 146 GLY A CA   1 
ATOM   2233 C C    . GLY A 1 146 ? -13.88776 -35.03189 9.47333   1.000 22.03815 ? 146 GLY A C    1 
ATOM   2234 O O    . GLY A 1 146 ? -14.25017 -35.82532 10.34973  1.000 24.33773 ? 146 GLY A O    1 
ATOM   2235 H H    . GLY A 1 146 ? -14.99896 -33.29244 7.52088   1.000 28.37412 ? 146 GLY A H    1 
ATOM   2236 H HA2  . GLY A 1 146 ? -15.47842 -35.28253 8.23073   1.000 28.58553 ? 146 GLY A HA2  1 
ATOM   2237 H HA3  . GLY A 1 146 ? -14.12821 -35.82324 7.61510   1.000 28.58553 ? 146 GLY A HA3  1 
ATOM   2238 N N    . SER A 1 147 ? -12.91406 -34.13864 9.66070   1.000 23.97878 ? 147 SER A N    1 
ATOM   2239 C CA   . SER A 1 147 ? -12.47337 -33.77492 10.99973  1.000 20.64738 ? 147 SER A CA   1 
ATOM   2240 C C    . SER A 1 147 ? -13.69043 -33.45945 11.85712  1.000 23.52691 ? 147 SER A C    1 
ATOM   2241 O O    . SER A 1 147 ? -14.64948 -32.84113 11.38913  1.000 26.25317 ? 147 SER A O    1 
ATOM   2242 C CB   . SER A 1 147 ? -11.53793 -32.56514 10.93904  1.000 24.11893 ? 147 SER A CB   1 
ATOM   2243 O OG   . SER A 1 147 ? -10.31172 -32.89208 10.30698  1.000 23.64089 ? 147 SER A OG   1 
ATOM   2244 H H    . SER A 1 147 ? -12.49601 -33.73207 9.02862   1.000 28.79731 ? 147 SER A H    1 
ATOM   2245 H HA   . SER A 1 147 ? -11.97972 -34.50667 11.40190  1.000 24.79963 ? 147 SER A HA   1 
ATOM   2246 H HB2  . SER A 1 147 ? -11.97153 -31.85820 10.43592  1.000 28.96549 ? 147 SER A HB2  1 
ATOM   2247 H HB3  . SER A 1 147 ? -11.35463 -32.26463 11.84292  1.000 28.96549 ? 147 SER A HB3  1 
ATOM   2248 H HG   . SER A 1 147 ? -10.19692 -32.40417 9.63291   1.000 28.39185 ? 147 SER A HG   1 
ATOM   2249 N N    . VAL A 1 148 ? -13.65607 -33.88857 13.11655  1.000 23.53256 ? 148 VAL A N    1 
ATOM   2250 C CA   . VAL A 1 148 ? -14.82698 -33.80464 13.97620  1.000 19.89447 ? 148 VAL A CA   1 
ATOM   2251 C C    . VAL A 1 148 ? -14.49993 -32.95996 15.19887  1.000 18.96912 ? 148 VAL A C    1 
ATOM   2252 O O    . VAL A 1 148 ? -13.33951 -32.78857 15.58106  1.000 17.34837 ? 148 VAL A O    1 
ATOM   2253 C CB   . VAL A 1 148 ? -15.33663 -35.20080 14.39169  1.000 21.68003 ? 148 VAL A CB   1 
ATOM   2254 C CG1  . VAL A 1 148 ? -15.85685 -35.94180 13.17390  1.000 22.05711 ? 148 VAL A CG1  1 
ATOM   2255 C CG2  . VAL A 1 148 ? -14.23355 -36.00286 15.07636  1.000 26.80774 ? 148 VAL A CG2  1 
ATOM   2256 H H    . VAL A 1 148 ? -12.96370 -34.23222 13.49356  1.000 28.26185 ? 148 VAL A H    1 
ATOM   2257 H HA   . VAL A 1 148 ? -15.53634 -33.35071 13.49490  1.000 23.89614 ? 148 VAL A HA   1 
ATOM   2258 H HB   . VAL A 1 148 ? -16.06161 -35.09596 15.02755  1.000 26.03882 ? 148 VAL A HB   1 
ATOM   2259 H HG11 . VAL A 1 148 ? -16.55784 -35.41494 12.75925  1.000 26.49131 ? 148 VAL A HG11 1 
ATOM   2260 H HG12 . VAL A 1 148 ? -15.12724 -36.07248 12.54821  1.000 26.49131 ? 148 VAL A HG12 1 
ATOM   2261 H HG13 . VAL A 1 148 ? -16.21028 -36.80062 13.45394  1.000 26.49131 ? 148 VAL A HG13 1 
ATOM   2262 H HG21 . VAL A 1 148 ? -14.58858 -36.86577 15.34138  1.000 32.19207 ? 148 VAL A HG21 1 
ATOM   2263 H HG22 . VAL A 1 148 ? -13.49898 -36.12422 14.45461  1.000 32.19207 ? 148 VAL A HG22 1 
ATOM   2264 H HG23 . VAL A 1 148 ? -13.92828 -35.51652 15.85814  1.000 32.19207 ? 148 VAL A HG23 1 
ATOM   2265 N N    . GLY A 1 149 ? -15.55186 -32.40754 15.79809  1.000 19.99717 ? 149 GLY A N    1 
ATOM   2266 C CA   . GLY A 1 149 ? -15.45233 -31.69071 17.05544  1.000 20.84472 ? 149 GLY A CA   1 
ATOM   2267 C C    . GLY A 1 149 ? -16.14792 -32.48052 18.14766  1.000 19.98696 ? 149 GLY A C    1 
ATOM   2268 O O    . GLY A 1 149 ? -17.13367 -33.17383 17.89192  1.000 21.63690 ? 149 GLY A O    1 
ATOM   2269 H H    . GLY A 1 149 ? -16.35180 -32.43808 15.48382  1.000 24.01938 ? 149 GLY A H    1 
ATOM   2270 H HA2  . GLY A 1 149 ? -14.52047 -31.56970 17.29603  1.000 25.03644 ? 149 GLY A HA2  1 
ATOM   2271 H HA3  . GLY A 1 149 ? -15.87355 -30.82055 16.97604  1.000 25.03644 ? 149 GLY A HA3  1 
ATOM   2272 N N    . PHE A 1 150 ? -15.64090 -32.37515 19.37368  1.000 22.76576 ? 150 PHE A N    1 
ATOM   2273 C CA   . PHE A 1 150 ? -16.12384 -33.26444 20.41916  1.000 23.12187 ? 150 PHE A CA   1 
ATOM   2274 C C    . PHE A 1 150 ? -15.89789 -32.65352 21.79379  1.000 25.80616 ? 150 PHE A C    1 
ATOM   2275 O O    . PHE A 1 150 ? -15.07615 -31.75064 21.97479  1.000 20.54335 ? 150 PHE A O    1 
ATOM   2276 C CB   . PHE A 1 150 ? -15.43018 -34.62948 20.33514  1.000 22.02242 ? 150 PHE A CB   1 
ATOM   2277 C CG   . PHE A 1 150 ? -13.94273 -34.56086 20.54947  1.000 22.23080 ? 150 PHE A CG   1 
ATOM   2278 C CD1  . PHE A 1 150 ? -13.09418 -34.19064 19.51705  1.000 21.36183 ? 150 PHE A CD1  1 
ATOM   2279 C CD2  . PHE A 1 150 ? -13.39451 -34.84769 21.78935  1.000 22.87591 ? 150 PHE A CD2  1 
ATOM   2280 C CE1  . PHE A 1 150 ? -11.72352 -34.11893 19.71605  1.000 21.11020 ? 150 PHE A CE1  1 
ATOM   2281 C CE2  . PHE A 1 150 ? -12.02758 -34.77702 21.99456  1.000 25.73726 ? 150 PHE A CE2  1 
ATOM   2282 C CZ   . PHE A 1 150 ? -11.19138 -34.41090 20.95681  1.000 23.37939 ? 150 PHE A CZ   1 
ATOM   2283 H H    . PHE A 1 150 ? -15.03574 -31.81376 19.61498  1.000 27.34168 ? 150 PHE A H    1 
ATOM   2284 H HA   . PHE A 1 150 ? -17.08147 -33.37114 20.30753  1.000 27.76902 ? 150 PHE A HA   1 
ATOM   2285 H HB2  . PHE A 1 150 ? -15.80193 -35.21176 21.01606  1.000 26.44968 ? 150 PHE A HB2  1 
ATOM   2286 H HB3  . PHE A 1 150 ? -15.58649 -35.00620 19.45505  1.000 26.44968 ? 150 PHE A HB3  1 
ATOM   2287 H HD1  . PHE A 1 150 ? -13.44841 -33.98805 18.68135  1.000 25.65697 ? 150 PHE A HD1  1 
ATOM   2288 H HD2  . PHE A 1 150 ? -13.95227 -35.09082 22.49269  1.000 27.47387 ? 150 PHE A HD2  1 
ATOM   2289 H HE1  . PHE A 1 150 ? -11.16342 -33.87457 19.01500  1.000 25.35502 ? 150 PHE A HE1  1 
ATOM   2290 H HE2  . PHE A 1 150 ? -11.67185 -34.97584 22.83052  1.000 30.90748 ? 150 PHE A HE2  1 
ATOM   2291 H HZ   . PHE A 1 150 ? -10.27283 -34.36126 21.09355  1.000 28.07805 ? 150 PHE A HZ   1 
ATOM   2292 N N    . ASN A 1 151 ? -16.65672 -33.16999 22.75752  1.000 23.01069 ? 151 ASN A N    1 
ATOM   2293 C CA   . ASN A 1 151 ? -16.42884 -32.97701 24.17919  1.000 24.60462 ? 151 ASN A CA   1 
ATOM   2294 C C    . ASN A 1 151 ? -16.23657 -34.34474 24.82169  1.000 28.21390 ? 151 ASN A C    1 
ATOM   2295 O O    . ASN A 1 151 ? -16.67225 -35.36607 24.28443  1.000 23.97187 ? 151 ASN A O    1 
ATOM   2296 C CB   . ASN A 1 151 ? -17.60657 -32.24943 24.84465  1.000 25.35440 ? 151 ASN A CB   1 
ATOM   2297 C CG   . ASN A 1 151 ? -17.66134 -30.77770 24.48938  1.000 31.54392 ? 151 ASN A CG   1 
ATOM   2298 O OD1  . ASN A 1 151 ? -18.46520 -30.35560 23.65737  1.000 30.45317 ? 151 ASN A OD1  1 
ATOM   2299 N ND2  . ASN A 1 151 ? -16.79560 -29.98849 25.11390  1.000 26.54258 ? 151 ASN A ND2  1 
ATOM   2300 H H    . ASN A 1 151 ? -17.34488 -33.66119 22.60017  1.000 27.63561 ? 151 ASN A H    1 
ATOM   2301 H HA   . ASN A 1 151 ? -15.63482 -32.43838 24.32169  1.000 29.54833 ? 151 ASN A HA   1 
ATOM   2302 H HB2  . ASN A 1 151 ? -18.43634 -32.65932 24.55418  1.000 30.44806 ? 151 ASN A HB2  1 
ATOM   2303 H HB3  . ASN A 1 151 ? -17.51984 -32.32255 25.80799  1.000 30.44806 ? 151 ASN A HB3  1 
ATOM   2304 H HD21 . ASN A 1 151 ? -16.78564 -29.14473 24.94788  1.000 31.87388 ? 151 ASN A HD21 1 
ATOM   2305 H HD22 . ASN A 1 151 ? -16.24472 -30.32100 25.68449  1.000 31.87388 ? 151 ASN A HD22 1 
ATOM   2306 N N    . ILE A 1 152 ? -15.57933 -34.37009 25.97734  1.000 27.29489 ? 152 ILE A N    1 
ATOM   2307 C CA   . ILE A 1 152 ? -15.41258 -35.60135 26.73851  1.000 29.29419 ? 152 ILE A CA   1 
ATOM   2308 C C    . ILE A 1 152 ? -15.88127 -35.35528 28.16413  1.000 35.96738 ? 152 ILE A C    1 
ATOM   2309 O O    . ILE A 1 152 ? -15.54919 -34.32975 28.77022  1.000 31.84801 ? 152 ILE A O    1 
ATOM   2310 C CB   . ILE A 1 152 ? -13.95575 -36.10675 26.72222  1.000 31.71228 ? 152 ILE A CB   1 
ATOM   2311 C CG1  . ILE A 1 152 ? -13.44352 -36.19803 25.28257  1.000 30.46721 ? 152 ILE A CG1  1 
ATOM   2312 C CG2  . ILE A 1 152 ? -13.86228 -37.47255 27.39374  1.000 33.11275 ? 152 ILE A CG2  1 
ATOM   2313 C CD1  . ILE A 1 152 ? -12.08423 -36.85112 25.15328  1.000 30.63493 ? 152 ILE A CD1  1 
ATOM   2314 H H    . ILE A 1 152 ? -15.21865 -33.68009 26.34260  1.000 32.77664 ? 152 ILE A H    1 
ATOM   2315 H HA   . ILE A 1 152 ? -15.97243 -36.29077 26.34841  1.000 35.17580 ? 152 ILE A HA   1 
ATOM   2316 H HB   . ILE A 1 152 ? -13.40729 -35.47493 27.21303  1.000 38.07752 ? 152 ILE A HB   1 
ATOM   2317 H HG12 . ILE A 1 152 ? -14.07274 -36.72062 24.76116  1.000 36.58343 ? 152 ILE A HG12 1 
ATOM   2318 H HG13 . ILE A 1 152 ? -13.37575 -35.30124 24.91915  1.000 36.58343 ? 152 ILE A HG13 1 
ATOM   2319 H HG21 . ILE A 1 152 ? -12.92936 -37.67926 27.56054  1.000 39.75807 ? 152 ILE A HG21 1 
ATOM   2320 H HG22 . ILE A 1 152 ? -14.35025 -37.44653 28.23166  1.000 39.75807 ? 152 ILE A HG22 1 
ATOM   2321 H HG23 . ILE A 1 152 ? -14.24916 -38.14045 26.80626  1.000 39.75807 ? 152 ILE A HG23 1 
ATOM   2322 H HD11 . ILE A 1 152 ? -12.17762 -37.80584 25.29712  1.000 36.78470 ? 152 ILE A HD11 1 
ATOM   2323 H HD12 . ILE A 1 152 ? -11.73650 -36.68311 24.26348  1.000 36.78470 ? 152 ILE A HD12 1 
ATOM   2324 H HD13 . ILE A 1 152 ? -11.48776 -36.47320 25.81833  1.000 36.78470 ? 152 ILE A HD13 1 
ATOM   2325 N N    . ASP A 1 153 ? -16.66685 -36.29098 28.68872  1.000 38.29257 ? 153 ASP A N    1 
ATOM   2326 C CA   . ASP A 1 153 ? -17.11726 -36.26812 30.07566  1.000 40.62643 ? 153 ASP A CA   1 
ATOM   2327 C C    . ASP A 1 153 ? -16.71444 -37.60185 30.69063  1.000 43.21893 ? 153 ASP A C    1 
ATOM   2328 O O    . ASP A 1 153 ? -17.32534 -38.63376 30.39598  1.000 44.07056 ? 153 ASP A O    1 
ATOM   2329 C CB   . ASP A 1 153 ? -18.62581 -36.04102 30.16308  1.000 46.80388 ? 153 ASP A CB   1 
ATOM   2330 C CG   . ASP A 1 153 ? -19.09802 -35.79295 31.58282  1.000 59.36764 ? 153 ASP A CG   1 
ATOM   2331 O OD1  . ASP A 1 153 ? -18.36772 -36.15196 32.53180  1.000 55.41074 ? 153 ASP A OD1  1 
ATOM   2332 O OD2  . ASP A 1 153 ? -20.20484 -35.23916 31.75024  1.000 71.32407 ? 153 ASP A OD2  1 
ATOM   2333 H H    . ASP A 1 153 ? -16.96022 -36.96844 28.24762  1.000 45.97387 ? 153 ASP A H    1 
ATOM   2334 H HA   . ASP A 1 153 ? -16.68561 -35.55011 30.56459  1.000 48.77449 ? 153 ASP A HA   1 
ATOM   2335 H HB2  . ASP A 1 153 ? -18.86072 -35.26629 29.62874  1.000 56.18743 ? 153 ASP A HB2  1 
ATOM   2336 H HB3  . ASP A 1 153 ? -19.08419 -36.82710 29.82713  1.000 56.18743 ? 153 ASP A HB3  1 
ATOM   2337 N N    . TYR A 1 154 ? -15.68282 -37.57972 31.53352  1.000 42.85730 ? 154 TYR A N    1 
ATOM   2338 C CA   . TYR A 1 154 ? -15.03962 -38.79489 32.02420  1.000 46.81257 ? 154 TYR A CA   1 
ATOM   2339 C C    . TYR A 1 154 ? -14.62463 -39.69424 30.86014  1.000 44.58286 ? 154 TYR A C    1 
ATOM   2340 O O    . TYR A 1 154 ? -13.56507 -39.47445 30.26707  1.000 40.67361 ? 154 TYR A O    1 
ATOM   2341 C CB   . TYR A 1 154 ? -15.94548 -39.54577 33.00696  1.000 50.61165 ? 154 TYR A CB   1 
ATOM   2342 C CG   . TYR A 1 154 ? -15.27391 -40.77005 33.59841  1.000 52.30087 ? 154 TYR A CG   1 
ATOM   2343 C CD1  . TYR A 1 154 ? -14.02096 -40.67926 34.19715  1.000 57.39564 ? 154 TYR A CD1  1 
ATOM   2344 C CD2  . TYR A 1 154 ? -15.88442 -42.01429 33.55110  1.000 52.79136 ? 154 TYR A CD2  1 
ATOM   2345 C CE1  . TYR A 1 154 ? -13.39826 -41.79537 34.72963  1.000 58.14577 ? 154 TYR A CE1  1 
ATOM   2346 C CE2  . TYR A 1 154 ? -15.26980 -43.13342 34.08176  1.000 59.27082 ? 154 TYR A CE2  1 
ATOM   2347 C CZ   . TYR A 1 154 ? -14.02891 -43.01826 34.66789  1.000 59.96876 ? 154 TYR A CZ   1 
ATOM   2348 O OH   . TYR A 1 154 ? -13.41707 -44.12918 35.19702  1.000 75.37930 ? 154 TYR A OH   1 
ATOM   2349 H H    . TYR A 1 154 ? -15.33021 -36.85847 31.84185  1.000 51.45154 ? 154 TYR A H    1 
ATOM   2350 H HA   . TYR A 1 154 ? -14.23755 -38.54873 32.51103  1.000 56.19787 ? 154 TYR A HA   1 
ATOM   2351 H HB2  . TYR A 1 154 ? -16.18335 -38.95126 33.73557  1.000 60.75675 ? 154 TYR A HB2  1 
ATOM   2352 H HB3  . TYR A 1 154 ? -16.74524 -39.83641 32.54134  1.000 60.75675 ? 154 TYR A HB3  1 
ATOM   2353 H HD1  . TYR A 1 154 ? -13.59423 -39.85407 34.24040  1.000 68.89755 ? 154 TYR A HD1  1 
ATOM   2354 H HD2  . TYR A 1 154 ? -16.72196 -42.09744 33.15549  1.000 63.37240 ? 154 TYR A HD2  1 
ATOM   2355 H HE1  . TYR A 1 154 ? -12.56036 -41.71989 35.12603  1.000 69.79770 ? 154 TYR A HE1  1 
ATOM   2356 H HE2  . TYR A 1 154 ? -15.69275 -43.96077 34.04302  1.000 71.14776 ? 154 TYR A HE2  1 
ATOM   2357 H HH   . TYR A 1 154 ? -13.62061 -44.21044 36.00793  1.000 90.47793 ? 154 TYR A HH   1 
ATOM   2358 N N    . ASP A 1 155 ? -15.44116 -40.69500 30.51208  1.000 44.03293 ? 155 ASP A N    1 
ATOM   2359 C CA   . ASP A 1 155 ? -15.08347 -41.67272 29.48807  1.000 45.98976 ? 155 ASP A CA   1 
ATOM   2360 C C    . ASP A 1 155 ? -16.00963 -41.65006 28.28036  1.000 44.29511 ? 155 ASP A C    1 
ATOM   2361 O O    . ASP A 1 155 ? -15.85893 -42.49436 27.38959  1.000 40.05981 ? 155 ASP A O    1 
ATOM   2362 C CB   . ASP A 1 155 ? -15.05858 -43.08903 30.08517  1.000 47.90218 ? 155 ASP A CB   1 
ATOM   2363 C CG   . ASP A 1 155 ? -16.41805 -43.54233 30.60168  1.000 53.08978 ? 155 ASP A CG   1 
ATOM   2364 O OD1  . ASP A 1 155 ? -17.40451 -42.78165 30.48396  1.000 51.57693 ? 155 ASP A OD1  1 
ATOM   2365 O OD2  . ASP A 1 155 ? -16.49867 -44.67003 31.13260  1.000 55.21131 ? 155 ASP A OD2  1 
ATOM   2366 H H    . ASP A 1 155 ? -16.21602 -40.82717 30.86097  1.000 52.86229 ? 155 ASP A H    1 
ATOM   2367 H HA   . ASP A 1 155 ? -14.18889 -41.46806 29.17385  1.000 55.21049 ? 155 ASP A HA   1 
ATOM   2368 H HB2  . ASP A 1 155 ? -14.77549 -43.71474 29.40015  1.000 57.50539 ? 155 ASP A HB2  1 
ATOM   2369 H HB3  . ASP A 1 155 ? -14.43560 -43.10661 30.82846  1.000 57.50539 ? 155 ASP A HB3  1 
ATOM   2370 N N    . CYS A 1 156 ? -16.95576 -40.71921 28.21499  1.000 38.73140 ? 156 CYS A N    1 
ATOM   2371 C CA   . CYS A 1 156 ? -17.90517 -40.65985 27.11193  1.000 33.59727 ? 156 CYS A CA   1 
ATOM   2372 C C    . CYS A 1 156 ? -17.55121 -39.51588 26.17041  1.000 33.29289 ? 156 CYS A C    1 
ATOM   2373 O O    . CYS A 1 156 ? -17.38163 -38.37277 26.60864  1.000 31.44453 ? 156 CYS A O    1 
ATOM   2374 C CB   . CYS A 1 156 ? -19.33438 -40.49096 27.62571  1.000 36.17525 ? 156 CYS A CB   1 
ATOM   2375 S SG   . CYS A 1 156 ? -20.57625 -40.59556 26.31406  1.000 42.28110 ? 156 CYS A SG   1 
ATOM   2376 H H    . CYS A 1 156 ? -17.06788 -40.10432 28.80570  1.000 46.50046 ? 156 CYS A H    1 
ATOM   2377 H HA   . CYS A 1 156 ? -17.85103 -41.48764 26.60920  1.000 40.33950 ? 156 CYS A HA   1 
ATOM   2378 H HB2  . CYS A 1 156 ? -19.52120 -41.19064 28.27105  1.000 43.43307 ? 156 CYS A HB2  1 
ATOM   2379 H HB3  . CYS A 1 156 ? -19.41638 -39.62090 28.04663  1.000 43.43307 ? 156 CYS A HB3  1 
ATOM   2380 H HG   . CYS A 1 156 ? -20.44121 -41.63521 25.73020  1.000 50.76009 ? 156 CYS A HG   1 
ATOM   2381 N N    . VAL A 1 157 ? -17.44780 -39.82418 24.88030  1.000 22.36661 ? 157 VAL A N    1 
ATOM   2382 C CA   . VAL A 1 157 ? -17.16758 -38.82357 23.85653  1.000 29.69381 ? 157 VAL A CA   1 
ATOM   2383 C C    . VAL A 1 157 ? -18.48902 -38.36290 23.25692  1.000 27.70758 ? 157 VAL A C    1 
ATOM   2384 O O    . VAL A 1 157 ? -19.22439 -39.16141 22.66570  1.000 26.20800 ? 157 VAL A O    1 
ATOM   2385 C CB   . VAL A 1 157 ? -16.23888 -39.37610 22.76396  1.000 24.10063 ? 157 VAL A CB   1 
ATOM   2386 C CG1  . VAL A 1 157 ? -16.02834 -38.31869 21.66366  1.000 25.86202 ? 157 VAL A CG1  1 
ATOM   2387 C CG2  . VAL A 1 157 ? -14.91326 -39.81548 23.35803  1.000 28.63458 ? 157 VAL A CG2  1 
ATOM   2388 H H    . VAL A 1 157 ? -17.53778 -40.62082 24.56907  1.000 26.86271 ? 157 VAL A H    1 
ATOM   2389 H HA   . VAL A 1 157 ? -16.73608 -38.06169 24.27396  1.000 35.65535 ? 157 VAL A HA   1 
ATOM   2390 H HB   . VAL A 1 157 ? -16.65147 -40.15565 22.36025  1.000 28.94353 ? 157 VAL A HB   1 
ATOM   2391 H HG11 . VAL A 1 157 ? -15.24907 -38.55991 21.13882  1.000 31.05721 ? 157 VAL A HG11 1 
ATOM   2392 H HG12 . VAL A 1 157 ? -16.81442 -38.29284 21.09595  1.000 31.05721 ? 157 VAL A HG12 1 
ATOM   2393 H HG13 . VAL A 1 157 ? -15.89203 -37.45303 22.07952  1.000 31.05721 ? 157 VAL A HG13 1 
ATOM   2394 H HG21 . VAL A 1 157 ? -14.65871 -39.19309 24.05712  1.000 34.38427 ? 157 VAL A HG21 1 
ATOM   2395 H HG22 . VAL A 1 157 ? -15.01305 -40.70636 23.72855  1.000 34.38427 ? 157 VAL A HG22 1 
ATOM   2396 H HG23 . VAL A 1 157 ? -14.24050 -39.82130 22.65928  1.000 34.38427 ? 157 VAL A HG23 1 
ATOM   2397 N N    . SER A 1 158 ? -18.79155 -37.07605 23.40226  1.000 27.29508 ? 158 SER A N    1 
ATOM   2398 C CA   . SER A 1 158 ? -19.94107 -36.45864 22.74508  1.000 26.20423 ? 158 SER A CA   1 
ATOM   2399 C C    . SER A 1 158 ? -19.43757 -35.79621 21.46768  1.000 24.29119 ? 158 SER A C    1 
ATOM   2400 O O    . SER A 1 158 ? -18.81017 -34.73487 21.51211  1.000 24.47865 ? 158 SER A O    1 
ATOM   2401 C CB   . SER A 1 158 ? -20.62939 -35.45269 23.66264  1.000 28.22866 ? 158 SER A CB   1 
ATOM   2402 O OG   . SER A 1 158 ? -21.28467 -36.10703 24.73342  1.000 30.92344 ? 158 SER A OG   1 
ATOM   2403 H H    . SER A 1 158 ? -18.33713 -36.52913 23.88597  1.000 32.77687 ? 158 SER A H    1 
ATOM   2404 H HA   . SER A 1 158 ? -20.58707 -37.14448 22.51442  1.000 31.46785 ? 158 SER A HA   1 
ATOM   2405 H HB2  . SER A 1 158 ? -19.96241 -34.84807 24.02385  1.000 33.89717 ? 158 SER A HB2  1 
ATOM   2406 H HB3  . SER A 1 158 ? -21.28486 -34.95511 23.14915  1.000 33.89717 ? 158 SER A HB3  1 
ATOM   2407 H HG   . SER A 1 158 ? -20.71972 -36.47749 25.23260  1.000 37.13091 ? 158 SER A HG   1 
ATOM   2408 N N    . PHE A 1 159 ? -19.69579 -36.43816 20.33063  1.000 27.54032 ? 159 PHE A N    1 
ATOM   2409 C CA   . PHE A 1 159 ? -19.39759 -35.84102 19.03781  1.000 23.32276 ? 159 PHE A CA   1 
ATOM   2410 C C    . PHE A 1 159 ? -20.48505 -34.83476 18.68986  1.000 24.75257 ? 159 PHE A C    1 
ATOM   2411 O O    . PHE A 1 159 ? -21.67775 -35.15155 18.75366  1.000 24.13238 ? 159 PHE A O    1 
ATOM   2412 C CB   . PHE A 1 159 ? -19.30754 -36.91273 17.95188  1.000 24.00055 ? 159 PHE A CB   1 
ATOM   2413 C CG   . PHE A 1 159 ? -18.17140 -37.87447 18.13334  1.000 20.75629 ? 159 PHE A CG   1 
ATOM   2414 C CD1  . PHE A 1 159 ? -16.88287 -37.51620 17.77861  1.000 21.68015 ? 159 PHE A CD1  1 
ATOM   2415 C CD2  . PHE A 1 159 ? -18.39540 -39.14661 18.63050  1.000 20.67653 ? 159 PHE A CD2  1 
ATOM   2416 C CE1  . PHE A 1 159 ? -15.83685 -38.39975 17.93448  1.000 21.00148 ? 159 PHE A CE1  1 
ATOM   2417 C CE2  . PHE A 1 159 ? -17.35260 -40.03534 18.78827  1.000 22.25254 ? 159 PHE A CE2  1 
ATOM   2418 C CZ   . PHE A 1 159 ? -16.07192 -39.66224 18.43988  1.000 22.60049 ? 159 PHE A CZ   1 
ATOM   2419 H H    . PHE A 1 159 ? -20.04457 -37.22285 20.28365  1.000 33.07117 ? 159 PHE A H    1 
ATOM   2420 H HA   . PHE A 1 159 ? -18.54130 -35.38710 19.07790  1.000 28.01009 ? 159 PHE A HA   1 
ATOM   2421 H HB2  . PHE A 1 159 ? -20.13077 -37.42575 17.95285  1.000 28.82343 ? 159 PHE A HB2  1 
ATOM   2422 H HB3  . PHE A 1 159 ? -19.18972 -36.47615 17.09373  1.000 28.82343 ? 159 PHE A HB3  1 
ATOM   2423 H HD1  . PHE A 1 159 ? -16.72078 -36.66903 17.43085  1.000 26.03896 ? 159 PHE A HD1  1 
ATOM   2424 H HD2  . PHE A 1 159 ? -19.25862 -39.40497 18.86072  1.000 24.83461 ? 159 PHE A HD2  1 
ATOM   2425 H HE1  . PHE A 1 159 ? -14.97370 -38.14559 17.69940  1.000 25.22455 ? 159 PHE A HE1  1 
ATOM   2426 H HE2  . PHE A 1 159 ? -17.51319 -40.88550 19.12934  1.000 26.72583 ? 159 PHE A HE2  1 
ATOM   2427 H HZ   . PHE A 1 159 ? -15.36759 -40.26034 18.54528  1.000 27.14337 ? 159 PHE A HZ   1 
ATOM   2428 N N    . CYS A 1 160 ? -20.07219 -33.62381 18.31359  1.000 22.69295 ? 160 CYS A N    1 
ATOM   2429 C CA   . CYS A 1 160 ? -21.01088 -32.55205 18.02265  1.000 23.72852 ? 160 CYS A CA   1 
ATOM   2430 C C    . CYS A 1 160 ? -20.79285 -31.86248 16.68309  1.000 23.34567 ? 160 CYS A C    1 
ATOM   2431 O O    . CYS A 1 160 ? -21.68636 -31.12665 16.24942  1.000 24.82518 ? 160 CYS A O    1 
ATOM   2432 C CB   . CYS A 1 160 ? -20.96327 -31.48274 19.12723  1.000 24.59069 ? 160 CYS A CB   1 
ATOM   2433 S SG   . CYS A 1 160 ? -19.34935 -30.69151 19.35469  1.000 28.80520 ? 160 CYS A SG   1 
ATOM   2434 H H    . CYS A 1 160 ? -19.24680 -33.40107 18.22021  1.000 27.25432 ? 160 CYS A H    1 
ATOM   2435 H HA   . CYS A 1 160 ? -21.90150 -32.93612 18.00833  1.000 28.49700 ? 160 CYS A HA   1 
ATOM   2436 H HB2  . CYS A 1 160 ? -21.60104 -30.78565 18.90764  1.000 29.53161 ? 160 CYS A HB2  1 
ATOM   2437 H HB3  . CYS A 1 160 ? -21.20442 -31.89981 19.96913  1.000 29.53161 ? 160 CYS A HB3  1 
ATOM   2438 H HG   . CYS A 1 160 ? -19.05513 -30.10776 18.34837  1.000 34.58901 ? 160 CYS A HG   1 
ATOM   2439 N N    . TYR A 1 161 ? -19.65805 -32.06974 16.01394  1.000 20.35222 ? 161 TYR A N    1 
ATOM   2440 C CA   . TYR A 1 161 ? -19.33093 -31.30561 14.81717  1.000 20.79157 ? 161 TYR A CA   1 
ATOM   2441 C C    . TYR A 1 161 ? -18.56396 -32.16442 13.82488  1.000 20.69938 ? 161 TYR A C    1 
ATOM   2442 O O    . TYR A 1 161 ? -17.69210 -32.94558 14.21156  1.000 17.96381 ? 161 TYR A O    1 
ATOM   2443 C CB   . TYR A 1 161 ? -18.49952 -30.06642 15.17902  1.000 19.08952 ? 161 TYR A CB   1 
ATOM   2444 C CG   . TYR A 1 161 ? -18.09912 -29.19506 14.01137  1.000 21.67498 ? 161 TYR A CG   1 
ATOM   2445 C CD1  . TYR A 1 161 ? -18.96474 -28.23847 13.51053  1.000 22.97885 ? 161 TYR A CD1  1 
ATOM   2446 C CD2  . TYR A 1 161 ? -16.84336 -29.31240 13.42892  1.000 21.49214 ? 161 TYR A CD2  1 
ATOM   2447 C CE1  . TYR A 1 161 ? -18.59837 -27.42702 12.45099  1.000 19.16847 ? 161 TYR A CE1  1 
ATOM   2448 C CE2  . TYR A 1 161 ? -16.46801 -28.51073 12.37252  1.000 21.13881 ? 161 TYR A CE2  1 
ATOM   2449 C CZ   . TYR A 1 161 ? -17.34686 -27.57050 11.88390  1.000 25.57142 ? 161 TYR A CZ   1 
ATOM   2450 O OH   . TYR A 1 161 ? -16.96193 -26.77056 10.82897  1.000 21.41889 ? 161 TYR A OH   1 
ATOM   2451 H H    . TYR A 1 161 ? -19.06233 -32.64895 16.23585  1.000 24.44545 ? 161 TYR A H    1 
ATOM   2452 H HA   . TYR A 1 161 ? -20.15517 -31.03357 14.38414  1.000 24.97267 ? 161 TYR A HA   1 
ATOM   2453 H HB2  . TYR A 1 161 ? -19.01862 -29.51631 15.78632  1.000 22.93020 ? 161 TYR A HB2  1 
ATOM   2454 H HB3  . TYR A 1 161 ? -17.68390 -30.36132 15.61341  1.000 22.93020 ? 161 TYR A HB3  1 
ATOM   2455 H HD1  . TYR A 1 161 ? -19.80688 -28.13924 13.89243  1.000 27.59740 ? 161 TYR A HD1  1 
ATOM   2456 H HD2  . TYR A 1 161 ? -16.24486 -29.94361 13.75796  1.000 25.81334 ? 161 TYR A HD2  1 
ATOM   2457 H HE1  . TYR A 1 161 ? -19.19067 -26.78946 12.12297  1.000 23.02494 ? 161 TYR A HE1  1 
ATOM   2458 H HE2  . TYR A 1 161 ? -15.62485 -28.60454 11.99150  1.000 25.38935 ? 161 TYR A HE2  1 
ATOM   2459 H HH   . TYR A 1 161 ? -17.36773 -26.03585 10.86253  1.000 25.72545 ? 161 TYR A HH   1 
ATOM   2460 N N    . MET A 1 162 ? -18.90565 -32.01331 12.54585  1.000 19.02511 ? 162 MET A N    1 
ATOM   2461 C CA   . MET A 1 162 ? -18.12053 -32.54174 11.43860  1.000 21.77438 ? 162 MET A CA   1 
ATOM   2462 C C    . MET A 1 162 ? -17.90678 -31.40879 10.44690  1.000 22.33535 ? 162 MET A C    1 
ATOM   2463 O O    . MET A 1 162 ? -18.85245 -30.68665 10.11480  1.000 19.90273 ? 162 MET A O    1 
ATOM   2464 C CB   . MET A 1 162 ? -18.81538 -33.73062 10.76631  1.000 20.42685 ? 162 MET A CB   1 
ATOM   2465 C CG   . MET A 1 162 ? -18.06803 -34.25764 9.54205   1.000 24.56953 ? 162 MET A CG   1 
ATOM   2466 S SD   . MET A 1 162 ? -18.61370 -35.87726 8.97072   1.000 25.03522 ? 162 MET A SD   1 
ATOM   2467 C CE   . MET A 1 162 ? -17.77566 -36.95471 10.12880  1.000 27.10282 ? 162 MET A CE   1 
ATOM   2468 H H    . MET A 1 162 ? -19.61144 -31.59436 12.28906  1.000 22.85291 ? 162 MET A H    1 
ATOM   2469 H HA   . MET A 1 162 ? -17.26459 -32.86468 11.76107  1.000 26.15203 ? 162 MET A HA   1 
ATOM   2470 H HB2  . MET A 1 162 ? -18.88556 -34.45552 11.40701  1.000 24.53499 ? 162 MET A HB2  1 
ATOM   2471 H HB3  . MET A 1 162 ? -19.69991 -33.45487 10.47914  1.000 24.53499 ? 162 MET A HB3  1 
ATOM   2472 H HG2  . MET A 1 162 ? -18.19297 -33.63253 8.81093   1.000 29.50622 ? 162 MET A HG2  1 
ATOM   2473 H HG3  . MET A 1 162 ? -17.12577 -34.32741 9.76153   1.000 29.50622 ? 162 MET A HG3  1 
ATOM   2474 H HE1  . MET A 1 162 ? -17.84896 -36.57860 11.01991  1.000 32.54616 ? 162 MET A HE1  1 
ATOM   2475 H HE2  . MET A 1 162 ? -18.19246 -37.83024 10.10399  1.000 32.54616 ? 162 MET A HE2  1 
ATOM   2476 H HE3  . MET A 1 162 ? -16.84202 -37.02552 9.87543   1.000 32.54616 ? 162 MET A HE3  1 
ATOM   2477 N N    . HIS A 1 163 ? -16.66784 -31.23721 9.99404   1.000 21.19143 ? 163 HIS A N    1 
ATOM   2478 C CA   . HIS A 1 163 ? -16.32815 -30.08650 9.17001   1.000 19.94040 ? 163 HIS A CA   1 
ATOM   2479 C C    . HIS A 1 163 ? -16.64615 -30.32526 7.69777   1.000 22.23457 ? 163 HIS A C    1 
ATOM   2480 O O    . HIS A 1 163 ? -16.44078 -31.42160 7.16874   1.000 22.03429 ? 163 HIS A O    1 
ATOM   2481 C CB   . HIS A 1 163 ? -14.84985 -29.73709 9.31060   1.000 19.37994 ? 163 HIS A CB   1 
ATOM   2482 C CG   . HIS A 1 163 ? -14.46516 -28.51570 8.54406   1.000 20.74907 ? 163 HIS A CG   1 
ATOM   2483 N ND1  . HIS A 1 163 ? -15.04224 -27.28525 8.77241   1.000 24.51146 ? 163 HIS A ND1  1 
ATOM   2484 C CD2  . HIS A 1 163 ? -13.59404 -28.34083 7.52408   1.000 23.09140 ? 163 HIS A CD2  1 
ATOM   2485 C CE1  . HIS A 1 163 ? -14.52753 -26.40061 7.93787   1.000 23.37795 ? 163 HIS A CE1  1 
ATOM   2486 N NE2  . HIS A 1 163 ? -13.64521 -27.01522 7.17089   1.000 20.00677 ? 163 HIS A NE2  1 
ATOM   2487 H H    . HIS A 1 163 ? -16.01151 -31.77059 10.15002  1.000 25.45249 ? 163 HIS A H    1 
ATOM   2488 H HA   . HIS A 1 163 ? -16.86193 -29.33583 9.47410   1.000 23.95126 ? 163 HIS A HA   1 
ATOM   2489 H HB2  . HIS A 1 163 ? -14.65139 -29.57808 10.24667  1.000 23.27871 ? 163 HIS A HB2  1 
ATOM   2490 H HB3  . HIS A 1 163 ? -14.31822 -30.47800 8.97996   1.000 23.27871 ? 163 HIS A HB3  1 
ATOM   2491 H HD2  . HIS A 1 163 ? -13.06054 -28.99577 7.13507   1.000 27.73246 ? 163 HIS A HD2  1 
ATOM   2492 H HE1  . HIS A 1 163 ? -14.74872 -25.49822 7.89714   1.000 28.07632 ? 163 HIS A HE1  1 
ATOM   2493 H HE2  . HIS A 1 163 ? -13.17841 -26.64497 6.55072   1.000 24.03090 ? 163 HIS A HE2  1 
ATOM   2494 N N    . HIS A 1 164 ? -17.11811 -29.27285 7.02803   1.000 19.50875 ? 164 HIS A N    1 
ATOM   2495 C CA   . HIS A 1 164 ? -17.53736 -29.35884 5.63037   1.000 22.17207 ? 164 HIS A CA   1 
ATOM   2496 C C    . HIS A 1 164 ? -16.99400 -28.23955 4.75203   1.000 21.35816 ? 164 HIS A C    1 
ATOM   2497 O O    . HIS A 1 164 ? -16.67163 -28.48848 3.58596   1.000 22.02498 ? 164 HIS A O    1 
ATOM   2498 C CB   . HIS A 1 164 ? -19.08066 -29.35651 5.53080   1.000 22.27710 ? 164 HIS A CB   1 
ATOM   2499 C CG   . HIS A 1 164 ? -19.72313 -30.63111 5.98071   1.000 22.21825 ? 164 HIS A CG   1 
ATOM   2500 N ND1  . HIS A 1 164 ? -20.33447 -31.50572 5.10824   1.000 21.17032 ? 164 HIS A ND1  1 
ATOM   2501 C CD2  . HIS A 1 164 ? -19.85173 -31.17732 7.21241   1.000 19.50381 ? 164 HIS A CD2  1 
ATOM   2502 C CE1  . HIS A 1 164 ? -20.81428 -32.53444 5.78390   1.000 23.63219 ? 164 HIS A CE1  1 
ATOM   2503 N NE2  . HIS A 1 164 ? -20.53470 -32.35961 7.06280   1.000 23.14096 ? 164 HIS A NE2  1 
ATOM   2504 H H    . HIS A 1 164 ? -17.20601 -28.48730 7.36684   1.000 23.43327 ? 164 HIS A H    1 
ATOM   2505 H HA   . HIS A 1 164 ? -17.19918 -30.19772 5.27993   1.000 26.62926 ? 164 HIS A HA   1 
ATOM   2506 H HB2  . HIS A 1 164 ? -19.42671 -28.64012 6.08572   1.000 26.75529 ? 164 HIS A HB2  1 
ATOM   2507 H HB3  . HIS A 1 164 ? -19.33206 -29.21035 4.60542   1.000 26.75529 ? 164 HIS A HB3  1 
ATOM   2508 H HD1  . HIS A 1 164 ? -20.39419 -31.39846 4.25705   1.000 25.42716 ? 164 HIS A HD1  1 
ATOM   2509 H HD2  . HIS A 1 164 ? -19.53661 -30.81912 8.01071   1.000 23.42735 ? 164 HIS A HD2  1 
ATOM   2510 H HE1  . HIS A 1 164 ? -21.27119 -33.25854 5.42083   1.000 28.38141 ? 164 HIS A HE1  1 
ATOM   2511 N N    . MET A 1 165 ? -16.88760 -27.01493 5.26414   1.000 20.32534 ? 165 MET A N    1 
ATOM   2512 C CA   . MET A 1 165 ? -16.77437 -25.89230 4.34439   1.000 21.04335 ? 165 MET A CA   1 
ATOM   2513 C C    . MET A 1 165 ? -16.18624 -24.66616 5.02847   1.000 24.57122 ? 165 MET A C    1 
ATOM   2514 O O    . MET A 1 165 ? -16.32924 -24.47805 6.23935   1.000 21.00694 ? 165 MET A O    1 
ATOM   2515 C CB   . MET A 1 165 ? -18.15575 -25.57348 3.76327   1.000 23.34754 ? 165 MET A CB   1 
ATOM   2516 C CG   . MET A 1 165 ? -18.17238 -24.46947 2.73230   1.000 29.29371 ? 165 MET A CG   1 
ATOM   2517 S SD   . MET A 1 165 ? -19.80425 -24.28439 1.99016   1.000 36.27653 ? 165 MET A SD   1 
ATOM   2518 C CE   . MET A 1 165 ? -19.50417 -22.92670 0.86052   1.000 45.62079 ? 165 MET A CE   1 
ATOM   2519 H H    . MET A 1 165 ? -16.87920 -26.82008 6.10173   1.000 24.41318 ? 165 MET A H    1 
ATOM   2520 H HA   . MET A 1 165 ? -16.15639 -26.12892 3.63516   1.000 25.27480 ? 165 MET A HA   1 
ATOM   2521 H HB2  . MET A 1 165 ? -18.50283 -26.37366 3.33884   1.000 28.03983 ? 165 MET A HB2  1 
ATOM   2522 H HB3  . MET A 1 165 ? -18.73963 -25.30304 4.48911   1.000 28.03983 ? 165 MET A HB3  1 
ATOM   2523 H HG2  . MET A 1 165 ? -17.93284 -23.63062 3.15638   1.000 35.17523 ? 165 MET A HG2  1 
ATOM   2524 H HG3  . MET A 1 165 ? -17.53860 -24.67816 2.02827   1.000 35.17523 ? 165 MET A HG3  1 
ATOM   2525 H HE1  . MET A 1 165 ? -20.33996 -22.67946 0.43482   1.000 54.76772 ? 165 MET A HE1  1 
ATOM   2526 H HE2  . MET A 1 165 ? -18.86254 -23.20948 0.19026   1.000 54.76772 ? 165 MET A HE2  1 
ATOM   2527 H HE3  . MET A 1 165 ? -19.15131 -22.17316 1.35909   1.000 54.76772 ? 165 MET A HE3  1 
ATOM   2528 N N    . GLU A 1 166 ? -15.51970 -23.83785 4.22418   1.000 23.10915 ? 166 GLU A N    1 
ATOM   2529 C CA   . GLU A 1 166 ? -15.01743 -22.53299 4.63838   1.000 24.78906 ? 166 GLU A CA   1 
ATOM   2530 C C    . GLU A 1 166 ? -15.75371 -21.44749 3.86263   1.000 28.57479 ? 166 GLU A C    1 
ATOM   2531 O O    . GLU A 1 166 ? -15.82702 -21.50222 2.63067   1.000 27.96219 ? 166 GLU A O    1 
ATOM   2532 C CB   . GLU A 1 166 ? -13.50745 -22.41855 4.39884   1.000 26.56677 ? 166 GLU A CB   1 
ATOM   2533 C CG   . GLU A 1 166 ? -12.92382 -21.05095 4.74475   1.000 24.28266 ? 166 GLU A CG   1 
ATOM   2534 C CD   . GLU A 1 166 ? -11.41110 -21.00230 4.62168   1.000 28.45007 ? 166 GLU A CD   1 
ATOM   2535 O OE1  . GLU A 1 166 ? -10.74037 -21.94539 5.09125   1.000 28.44686 ? 166 GLU A OE1  1 
ATOM   2536 O OE2  . GLU A 1 166 ? -10.89003 -20.01798 4.05411   1.000 30.48794 ? 166 GLU A OE2  1 
ATOM   2537 H H    . GLU A 1 166 ? -15.34062 -24.01915 3.40280   1.000 27.75375 ? 166 GLU A H    1 
ATOM   2538 H HA   . GLU A 1 166 ? -15.18339 -22.40751 5.58581   1.000 29.76965 ? 166 GLU A HA   1 
ATOM   2539 H HB2  . GLU A 1 166 ? -13.05519 -23.07914 4.94656   1.000 31.90290 ? 166 GLU A HB2  1 
ATOM   2540 H HB3  . GLU A 1 166 ? -13.32825 -22.58674 3.46049   1.000 31.90290 ? 166 GLU A HB3  1 
ATOM   2541 H HG2  . GLU A 1 166 ? -13.29419 -20.38843 4.14076   1.000 29.16197 ? 166 GLU A HG2  1 
ATOM   2542 H HG3  . GLU A 1 166 ? -13.15629 -20.83170 5.66060   1.000 29.16197 ? 166 GLU A HG3  1 
ATOM   2543 N N    . LEU A 1 167 ? -16.29651 -20.46738 4.57934   1.000 29.45096 ? 167 LEU A N    1 
ATOM   2544 C CA   . LEU A 1 167 ? -17.00571 -19.36884 3.94277   1.000 28.16359 ? 167 LEU A CA   1 
ATOM   2545 C C    . LEU A 1 167 ? -16.01038 -18.39183 3.32687   1.000 32.05266 ? 167 LEU A C    1 
ATOM   2546 O O    . LEU A 1 167 ? -14.80616 -18.46562 3.58139   1.000 29.22282 ? 167 LEU A O    1 
ATOM   2547 C CB   . LEU A 1 167 ? -17.89943 -18.66193 4.95862   1.000 28.64906 ? 167 LEU A CB   1 
ATOM   2548 C CG   . LEU A 1 167 ? -18.88978 -19.57117 5.68991   1.000 26.25146 ? 167 LEU A CG   1 
ATOM   2549 C CD1  . LEU A 1 167 ? -19.75467 -18.76713 6.64507   1.000 28.83459 ? 167 LEU A CD1  1 
ATOM   2550 C CD2  . LEU A 1 167 ? -19.74919 -20.33745 4.69896   1.000 26.95508 ? 167 LEU A CD2  1 
ATOM   2551 H H    . LEU A 1 167 ? -16.26617 -20.41824 5.43740   1.000 35.36393 ? 167 LEU A H    1 
ATOM   2552 H HA   . LEU A 1 167 ? -17.57244 -19.71925 3.23783   1.000 33.81909 ? 167 LEU A HA   1 
ATOM   2553 H HB2  . LEU A 1 167 ? -17.33363 -18.24798 5.62900   1.000 34.40165 ? 167 LEU A HB2  1 
ATOM   2554 H HB3  . LEU A 1 167 ? -18.41430 -17.98357 4.49426   1.000 34.40165 ? 167 LEU A HB3  1 
ATOM   2555 H HG   . LEU A 1 167 ? -18.39155 -20.21800 6.21363   1.000 31.52454 ? 167 LEU A HG   1 
ATOM   2556 H HD11 . LEU A 1 167 ? -19.18062 -18.27064 7.24910   1.000 34.62429 ? 167 LEU A HD11 1 
ATOM   2557 H HD12 . LEU A 1 167 ? -20.30493 -18.15409 6.13293   1.000 34.62429 ? 167 LEU A HD12 1 
ATOM   2558 H HD13 . LEU A 1 167 ? -20.31797 -19.37514 7.14898   1.000 34.62429 ? 167 LEU A HD13 1 
ATOM   2559 H HD21 . LEU A 1 167 ? -20.49997 -20.73113 5.17039   1.000 32.36887 ? 167 LEU A HD21 1 
ATOM   2560 H HD22 . LEU A 1 167 ? -20.07013 -19.72445 4.01916   1.000 32.36887 ? 167 LEU A HD22 1 
ATOM   2561 H HD23 . LEU A 1 167 ? -19.21344 -21.03464 4.28933   1.000 32.36887 ? 167 LEU A HD23 1 
ATOM   2562 N N    . PRO A 1 168 ? -16.48524 -17.46077 2.49432   1.000 31.17118 ? 168 PRO A N    1 
ATOM   2563 C CA   . PRO A 1 168 ? -15.57122 -16.45002 1.93625   1.000 35.16224 ? 168 PRO A CA   1 
ATOM   2564 C C    . PRO A 1 168 ? -14.91934 -15.56936 2.98940   1.000 33.38621 ? 168 PRO A C    1 
ATOM   2565 O O    . PRO A 1 168 ? -13.85176 -15.00376 2.72322   1.000 34.00781 ? 168 PRO A O    1 
ATOM   2566 C CB   . PRO A 1 168 ? -16.47607 -15.63055 1.00341   1.000 32.70780 ? 168 PRO A CB   1 
ATOM   2567 C CG   . PRO A 1 168 ? -17.61191 -16.54574 0.66603   1.000 34.28001 ? 168 PRO A CG   1 
ATOM   2568 C CD   . PRO A 1 168 ? -17.83381 -17.37041 1.90648   1.000 29.86703 ? 168 PRO A CD   1 
ATOM   2569 H HA   . PRO A 1 168 ? -14.88052 -16.88394 1.41133   1.000 42.21746 ? 168 PRO A HA   1 
ATOM   2570 H HB2  . PRO A 1 168 ? -16.79355 -14.83783 1.46352   1.000 39.27214 ? 168 PRO A HB2  1 
ATOM   2571 H HB3  . PRO A 1 168 ? -15.98546 -15.37715 0.20592   1.000 39.27214 ? 168 PRO A HB3  1 
ATOM   2572 H HG2  . PRO A 1 168 ? -18.40181 -16.02582 0.45006   1.000 41.15878 ? 168 PRO A HG2  1 
ATOM   2573 H HG3  . PRO A 1 168 ? -17.36985 -17.10914 -0.08555  1.000 41.15878 ? 168 PRO A HG3  1 
ATOM   2574 H HD2  . PRO A 1 168 ? -18.44623 -16.92518 2.51279   1.000 35.86321 ? 168 PRO A HD2  1 
ATOM   2575 H HD3  . PRO A 1 168 ? -18.17224 -18.25090 1.68044   1.000 35.86321 ? 168 PRO A HD3  1 
ATOM   2576 N N    . THR A 1 169 ? -15.51893 -15.43032 4.17217   1.000 33.09784 ? 169 THR A N    1 
ATOM   2577 C CA   . THR A 1 169 ? -14.95189 -14.58671 5.21797   1.000 33.18010 ? 169 THR A CA   1 
ATOM   2578 C C    . THR A 1 169 ? -13.82335 -15.26614 5.98358   1.000 33.75954 ? 169 THR A C    1 
ATOM   2579 O O    . THR A 1 169 ? -13.24067 -14.64056 6.87566   1.000 32.00970 ? 169 THR A O    1 
ATOM   2580 C CB   . THR A 1 169 ? -16.04196 -14.15458 6.20672   1.000 33.58668 ? 169 THR A CB   1 
ATOM   2581 O OG1  . THR A 1 169 ? -16.56781 -15.30337 6.88367   1.000 35.05047 ? 169 THR A OG1  1 
ATOM   2582 C CG2  . THR A 1 169 ? -17.17577 -13.43099 5.48255   1.000 35.49393 ? 169 THR A CG2  1 
ATOM   2583 H H    . THR A 1 169 ? -16.25589 -15.81565 4.39129   1.000 39.74019 ? 169 THR A H    1 
ATOM   2584 H HA   . THR A 1 169 ? -14.59474 -13.78807 4.79901   1.000 39.83890 ? 169 THR A HA   1 
ATOM   2585 H HB   . THR A 1 169 ? -15.65817 -13.54530 6.85663   1.000 40.32679 ? 169 THR A HB   1 
ATOM   2586 H HG1  . THR A 1 169 ? -16.91322 -15.83081 6.32861   1.000 42.08334 ? 169 THR A HG1  1 
ATOM   2587 H HG21 . THR A 1 169 ? -16.84719 -12.60567 5.09296   1.000 42.61549 ? 169 THR A HG21 1 
ATOM   2588 H HG22 . THR A 1 169 ? -17.53040 -13.99324 4.77615   1.000 42.61549 ? 169 THR A HG22 1 
ATOM   2589 H HG23 . THR A 1 169 ? -17.88842 -13.22261 6.10673   1.000 42.61549 ? 169 THR A HG23 1 
ATOM   2590 N N    . GLY A 1 170 ? -13.50213 -16.51851 5.66617   1.000 28.33095 ? 170 GLY A N    1 
ATOM   2591 C CA   . GLY A 1 170 ? -12.44934 -17.23432 6.35196   1.000 27.91560 ? 170 GLY A CA   1 
ATOM   2592 C C    . GLY A 1 170 ? -12.89547 -18.06224 7.53703   1.000 29.54039 ? 170 GLY A C    1 
ATOM   2593 O O    . GLY A 1 170 ? -12.05308 -18.72309 8.15895   1.000 28.00173 ? 170 GLY A O    1 
ATOM   2594 H H    . GLY A 1 170 ? -13.88872 -16.97473 5.04809   1.000 34.01992 ? 170 GLY A H    1 
ATOM   2595 H HA2  . GLY A 1 170 ? -12.02061 -17.83264 5.72021   1.000 33.52150 ? 170 GLY A HA2  1 
ATOM   2596 H HA3  . GLY A 1 170 ? -11.79657 -16.59186 6.67138   1.000 33.52150 ? 170 GLY A HA3  1 
ATOM   2597 N N    . VAL A 1 171 ? -14.18417 -18.04855 7.87598   1.000 24.56283 ? 171 VAL A N    1 
ATOM   2598 C CA   . VAL A 1 171 ? -14.69183 -18.83900 8.99186   1.000 26.38328 ? 171 VAL A CA   1 
ATOM   2599 C C    . VAL A 1 171 ? -15.18323 -20.17676 8.45604   1.000 23.27141 ? 171 VAL A C    1 
ATOM   2600 O O    . VAL A 1 171 ? -15.24605 -20.38708 7.23927   1.000 24.72718 ? 171 VAL A O    1 
ATOM   2601 C CB   . VAL A 1 171 ? -15.80569 -18.09720 9.75241   1.000 24.32619 ? 171 VAL A CB   1 
ATOM   2602 C CG1  . VAL A 1 171 ? -15.31414 -16.72284 10.20450  1.000 28.99488 ? 171 VAL A CG1  1 
ATOM   2603 C CG2  . VAL A 1 171 ? -17.06117 -17.98730 8.89515   1.000 22.77873 ? 171 VAL A CG2  1 
ATOM   2604 H H    . VAL A 1 171 ? -14.78632 -17.58636 7.47175   1.000 29.49818 ? 171 VAL A H    1 
ATOM   2605 H HA   . VAL A 1 171 ? -13.97088 -19.00307 9.61971   1.000 31.68272 ? 171 VAL A HA   1 
ATOM   2606 H HB   . VAL A 1 171 ? -16.04108 -18.60249 10.54624  1.000 29.21421 ? 171 VAL A HB   1 
ATOM   2607 H HG11 . VAL A 1 171 ? -14.37835 -16.62839 9.96729   1.000 34.81663 ? 171 VAL A HG11 1 
ATOM   2608 H HG12 . VAL A 1 171 ? -15.83862 -16.03814 9.76064   1.000 34.81663 ? 171 VAL A HG12 1 
ATOM   2609 H HG13 . VAL A 1 171 ? -15.42068 -16.64986 11.16586  1.000 34.81663 ? 171 VAL A HG13 1 
ATOM   2610 H HG21 . VAL A 1 171 ? -17.59407 -17.24040 9.20986   1.000 27.35725 ? 171 VAL A HG21 1 
ATOM   2611 H HG22 . VAL A 1 171 ? -16.80145 -17.84254 7.97185   1.000 27.35725 ? 171 VAL A HG22 1 
ATOM   2612 H HG23 . VAL A 1 171 ? -17.56835 -18.81066 8.97090   1.000 27.35725 ? 171 VAL A HG23 1 
ATOM   2613 N N    . HIS A 1 172 ? -15.54937 -21.08096 9.35878   1.000 22.38606 ? 172 HIS A N    1 
ATOM   2614 C CA   . HIS A 1 172 ? -15.75193 -22.48264 9.02517   1.000 24.03971 ? 172 HIS A CA   1 
ATOM   2615 C C    . HIS A 1 172 ? -17.11371 -22.96212 9.50210   1.000 23.97717 ? 172 HIS A C    1 
ATOM   2616 O O    . HIS A 1 172 ? -17.57369 -22.58183 10.58302  1.000 21.98091 ? 172 HIS A O    1 
ATOM   2617 C CB   . HIS A 1 172 ? -14.63761 -23.32179 9.64295   1.000 23.60274 ? 172 HIS A CB   1 
ATOM   2618 C CG   . HIS A 1 172 ? -13.27583 -22.96507 9.13497   1.000 23.99003 ? 172 HIS A CG   1 
ATOM   2619 N ND1  . HIS A 1 172 ? -12.29717 -22.42684 9.94180   1.000 20.89978 ? 172 HIS A ND1  1 
ATOM   2620 C CD2  . HIS A 1 172 ? -12.73630 -23.05056 7.89562   1.000 22.49285 ? 172 HIS A CD2  1 
ATOM   2621 C CE1  . HIS A 1 172 ? -11.20909 -22.20758 9.22517   1.000 26.59456 ? 172 HIS A CE1  1 
ATOM   2622 N NE2  . HIS A 1 172 ? -11.44921 -22.57768 7.97998   1.000 22.64886 ? 172 HIS A NE2  1 
ATOM   2623 H H    . HIS A 1 172 ? -15.68896 -20.90081 10.18803  1.000 26.88605 ? 172 HIS A H    1 
ATOM   2624 H HA   . HIS A 1 172 ? -15.74686 -22.59988 8.06230   1.000 28.87043 ? 172 HIS A HA   1 
ATOM   2625 H HB2  . HIS A 1 172 ? -14.64124 -23.18923 10.60384  1.000 28.34607 ? 172 HIS A HB2  1 
ATOM   2626 H HB3  . HIS A 1 172 ? -14.79731 -24.25598 9.43632   1.000 28.34607 ? 172 HIS A HB3  1 
ATOM   2627 H HD2  . HIS A 1 172 ? -13.15816 -23.36966 7.13070   1.000 27.01420 ? 172 HIS A HD2  1 
ATOM   2628 H HE1  . HIS A 1 172 ? -10.41026 -21.85309 9.54315   1.000 31.93625 ? 172 HIS A HE1  1 
ATOM   2629 H HE2  . HIS A 1 172 ? -10.89046 -22.53028 7.32794   1.000 27.20141 ? 172 HIS A HE2  1 
ATOM   2630 N N    . VAL A 1 173 ? -17.74725 -23.81182 8.68946   1.000 19.82062 ? 173 VAL A N    1 
ATOM   2631 C CA   . VAL A 1 173 ? -19.10180 -24.28732 8.93656   1.000 20.24813 ? 173 VAL A CA   1 
ATOM   2632 C C    . VAL A 1 173 ? -19.14314 -25.79815 8.76093   1.000 20.07582 ? 173 VAL A C    1 
ATOM   2633 O O    . VAL A 1 173 ? -18.34809 -26.38522 8.01926   1.000 19.46778 ? 173 VAL A O    1 
ATOM   2634 C CB   . VAL A 1 173 ? -20.13008 -23.60447 8.00521   1.000 21.43490 ? 173 VAL A CB   1 
ATOM   2635 C CG1  . VAL A 1 173 ? -20.18307 -22.10880 8.27969   1.000 24.88055 ? 173 VAL A CG1  1 
ATOM   2636 C CG2  . VAL A 1 173 ? -19.79323 -23.87074 6.54382   1.000 20.61213 ? 173 VAL A CG2  1 
ATOM   2637 H H    . VAL A 1 173 ? -17.40015 -24.13271 7.97103   1.000 23.80752 ? 173 VAL A H    1 
ATOM   2638 H HA   . VAL A 1 173 ? -19.34054 -24.08735 9.85521   1.000 24.32053 ? 173 VAL A HA   1 
ATOM   2639 N N    . GLY A 1 174 ? -20.08582 -26.42712 9.44852   1.000 18.67906 ? 174 GLY A N    1 
ATOM   2640 C CA   . GLY A 1 174 ? -20.18371 -27.86702 9.41405   1.000 20.38572 ? 174 GLY A CA   1 
ATOM   2641 C C    . GLY A 1 174 ? -21.53184 -28.33304 9.90833   1.000 20.28430 ? 174 GLY A C    1 
ATOM   2642 O O    . GLY A 1 174 ? -22.46901 -27.54545 10.05483  1.000 19.05455 ? 174 GLY A O    1 
ATOM   2643 H H    . GLY A 1 174 ? -20.67627 -26.03974 9.93935   1.000 22.43765 ? 174 GLY A H    1 
ATOM   2644 H HA2  . GLY A 1 174 ? -20.06096 -28.18068 8.50441   1.000 24.48564 ? 174 GLY A HA2  1 
ATOM   2645 H HA3  . GLY A 1 174 ? -19.49548 -28.25438 9.97725   1.000 24.48564 ? 174 GLY A HA3  1 
ATOM   2646 N N    . THR A 1 175 ? -21.60865 -29.63470 10.16449  1.000 21.60193 ? 175 THR A N    1 
ATOM   2647 C CA   . THR A 1 175 ? -22.83407 -30.31260 10.55194  1.000 22.04943 ? 175 THR A CA   1 
ATOM   2648 C C    . THR A 1 175 ? -22.65530 -30.99649 11.90053  1.000 24.55129 ? 175 THR A C    1 
ATOM   2649 O O    . THR A 1 175 ? -21.54081 -31.14694 12.41090  1.000 21.04337 ? 175 THR A O    1 
ATOM   2650 C CB   . THR A 1 175 ? -23.23698 -31.36810 9.51163   1.000 21.50305 ? 175 THR A CB   1 
ATOM   2651 O OG1  . THR A 1 175 ? -22.25957 -32.41712 9.49707   1.000 19.29824 ? 175 THR A OG1  1 
ATOM   2652 C CG2  . THR A 1 175 ? -23.36057 -30.75720 8.12580   1.000 23.69760 ? 175 THR A CG2  1 
ATOM   2653 H H    . THR A 1 175 ? -20.93391 -30.16588 10.11772  1.000 25.94509 ? 175 THR A H    1 
ATOM   2654 H HA   . THR A 1 175 ? -23.53845 -29.64978 10.62556  1.000 26.48209 ? 175 THR A HA   1 
ATOM   2655 H HB   . THR A 1 175 ? -24.10380 -31.73544 9.74526   1.000 25.82643 ? 175 THR A HB   1 
ATOM   2656 H HG1  . THR A 1 175 ? -22.41560 -32.96378 10.11546  1.000 23.18067 ? 175 THR A HG1  1 
ATOM   2657 H HG21 . THR A 1 175 ? -23.80721 -31.37738 7.52848   1.000 28.45990 ? 175 THR A HG21 1 
ATOM   2658 H HG22 . THR A 1 175 ? -23.87552 -29.93636 8.16980   1.000 28.45990 ? 175 THR A HG22 1 
ATOM   2659 H HG23 . THR A 1 175 ? -22.47993 -30.55774 7.77143   1.000 28.45990 ? 175 THR A HG23 1 
ATOM   2660 N N    . ASP A 1 176 ? -23.78116 -31.41900 12.47203  1.000 24.07045 ? 176 ASP A N    1 
ATOM   2661 C CA   . ASP A 1 176 ? -23.75957 -32.41213 13.53282  1.000 21.69752 ? 176 ASP A CA   1 
ATOM   2662 C C    . ASP A 1 176 ? -23.55504 -33.78670 12.89406  1.000 20.03691 ? 176 ASP A C    1 
ATOM   2663 O O    . ASP A 1 176 ? -23.47153 -33.91865 11.67021  1.000 24.34180 ? 176 ASP A O    1 
ATOM   2664 C CB   . ASP A 1 176 ? -25.03598 -32.33094 14.37639  1.000 23.74469 ? 176 ASP A CB   1 
ATOM   2665 C CG   . ASP A 1 176 ? -26.30028 -32.69848 13.60352  1.000 25.63065 ? 176 ASP A CG   1 
ATOM   2666 O OD1  . ASP A 1 176 ? -26.21367 -33.37704 12.55993  1.000 23.08741 ? 176 ASP A OD1  1 
ATOM   2667 O OD2  . ASP A 1 176 ? -27.39989 -32.30888 14.05717  1.000 27.68681 ? 176 ASP A OD2  1 
ATOM   2668 H H    . ASP A 1 176 ? -24.56800 -31.14370 12.26066  1.000 28.90731 ? 176 ASP A H    1 
ATOM   2669 H HA   . ASP A 1 176 ? -23.02475 -32.24134 14.14254  1.000 26.05980 ? 176 ASP A HA   1 
ATOM   2670 H HB2  . ASP A 1 176 ? -24.95669 -32.94343 15.12437  1.000 28.51640 ? 176 ASP A HB2  1 
ATOM   2671 H HB3  . ASP A 1 176 ? -25.13986 -31.42274 14.70086  1.000 28.51640 ? 176 ASP A HB3  1 
ATOM   2672 N N    . LEU A 1 177 ? -23.46675 -34.83023 13.71393  1.000 18.99255 ? 177 LEU A N    1 
ATOM   2673 C CA   . LEU A 1 177 ? -23.14491 -36.15013 13.18110  1.000 22.32287 ? 177 LEU A CA   1 
ATOM   2674 C C    . LEU A 1 177 ? -24.34237 -36.84960 12.55160  1.000 24.73172 ? 177 LEU A C    1 
ATOM   2675 O O    . LEU A 1 177 ? -24.20921 -38.00049 12.11925  1.000 26.79371 ? 177 LEU A O    1 
ATOM   2676 C CB   . LEU A 1 177 ? -22.53501 -37.02486 14.27832  1.000 24.08589 ? 177 LEU A CB   1 
ATOM   2677 C CG   . LEU A 1 177 ? -21.00528 -36.95534 14.36444  1.000 24.39390 ? 177 LEU A CG   1 
ATOM   2678 C CD1  . LEU A 1 177 ? -20.36510 -37.57426 13.12618  1.000 23.00945 ? 177 LEU A CD1  1 
ATOM   2679 C CD2  . LEU A 1 177 ? -20.52082 -35.51208 14.54626  1.000 24.85084 ? 177 LEU A CD2  1 
ATOM   2680 H H    . LEU A 1 177 ? -23.58643 -34.79995 14.56503  1.000 22.81383 ? 177 LEU A H    1 
ATOM   2681 H HA   . LEU A 1 177 ? -22.47619 -36.04830 12.48588  1.000 26.81022 ? 177 LEU A HA   1 
ATOM   2682 H HB2  . LEU A 1 177 ? -22.89128 -36.73991 15.13434  1.000 28.92584 ? 177 LEU A HB2  1 
ATOM   2683 H HB3  . LEU A 1 177 ? -22.77861 -37.94827 14.10838  1.000 28.92584 ? 177 LEU A HB3  1 
ATOM   2684 H HG   . LEU A 1 177 ? -20.72360 -37.46283 15.14162  1.000 29.29545 ? 177 LEU A HG   1 
ATOM   2685 H HD11 . LEU A 1 177 ? -20.43751 -36.94967 12.38757  1.000 27.63412 ? 177 LEU A HD11 1 
ATOM   2686 H HD12 . LEU A 1 177 ? -19.43133 -37.75938 13.31250  1.000 27.63412 ? 177 LEU A HD12 1 
ATOM   2687 H HD13 . LEU A 1 177 ? -20.82878 -38.39819 12.90930  1.000 27.63412 ? 177 LEU A HD13 1 
ATOM   2688 H HD21 . LEU A 1 177 ? -20.84038 -34.97580 13.80385  1.000 29.84378 ? 177 LEU A HD21 1 
ATOM   2689 H HD22 . LEU A 1 177 ? -20.87166 -35.16398 15.38091  1.000 29.84378 ? 177 LEU A HD22 1 
ATOM   2690 H HD23 . LEU A 1 177 ? -19.55106 -35.50466 14.56637  1.000 29.84378 ? 177 LEU A HD23 1 
ATOM   2691 N N    . GLU A 1 178 ? -25.49812 -36.19309 12.48483  1.000 20.44010 ? 178 GLU A N    1 
ATOM   2692 C CA   . GLU A 1 178 ? -26.60282 -36.64387 11.65210  1.000 27.18260 ? 178 GLU A CA   1 
ATOM   2693 C C    . GLU A 1 178 ? -26.67407 -35.87981 10.33521  1.000 23.06227 ? 178 GLU A C    1 
ATOM   2694 O O    . GLU A 1 178 ? -27.63594 -36.05050 9.58023   1.000 24.92915 ? 178 GLU A O    1 
ATOM   2695 C CB   . GLU A 1 178 ? -27.92637 -36.51921 12.40996  1.000 28.59722 ? 178 GLU A CB   1 
ATOM   2696 C CG   . GLU A 1 178 ? -28.04116 -37.46241 13.60190  1.000 34.31683 ? 178 GLU A CG   1 
ATOM   2697 C CD   . GLU A 1 178 ? -29.40017 -37.39704 14.27075  1.000 46.69540 ? 178 GLU A CD   1 
ATOM   2698 O OE1  . GLU A 1 178 ? -30.11223 -36.38896 14.07751  1.000 45.43017 ? 178 GLU A OE1  1 
ATOM   2699 O OE2  . GLU A 1 178 ? -29.75776 -38.35697 14.98583  1.000 59.48628 ? 178 GLU A OE2  1 
ATOM   2700 H H    . GLU A 1 178 ? -25.66638 -35.47153 12.92146  1.000 24.55090 ? 178 GLU A H    1 
ATOM   2701 H HA   . GLU A 1 178 ? -26.47622 -37.58346 11.44706  1.000 32.64190 ? 178 GLU A HA   1 
ATOM   2702 H HB2  . GLU A 1 178 ? -28.01206 -35.61148 12.74099  1.000 34.33944 ? 178 GLU A HB2  1 
ATOM   2703 H HB3  . GLU A 1 178 ? -28.65447 -36.72056 11.80149  1.000 34.33944 ? 178 GLU A HB3  1 
ATOM   2704 H HG2  . GLU A 1 178 ? -27.89885 -38.37304 13.29957  1.000 41.20297 ? 178 GLU A HG2  1 
ATOM   2705 H HG3  . GLU A 1 178 ? -27.37056 -37.22290 14.26056  1.000 41.20297 ? 178 GLU A HG3  1 
ATOM   2706 N N    . GLY A 1 179 ? -25.68120 -35.04183 10.04511  1.000 22.99780 ? 179 GLY A N    1 
ATOM   2707 C CA   . GLY A 1 179 ? -25.58847 -34.38431 8.75900   1.000 24.04462 ? 179 GLY A CA   1 
ATOM   2708 C C    . GLY A 1 179 ? -26.36957 -33.09751 8.61630   1.000 23.41543 ? 179 GLY A C    1 
ATOM   2709 O O    . GLY A 1 179 ? -26.47067 -32.58128 7.49773   1.000 23.57417 ? 179 GLY A O    1 
ATOM   2710 H H    . GLY A 1 179 ? -25.04482 -34.83963 10.58708  1.000 27.62014 ? 179 GLY A H    1 
ATOM   2711 H HA2  . GLY A 1 179 ? -24.65617 -34.17977 8.58615   1.000 28.87632 ? 179 GLY A HA2  1 
ATOM   2712 H HA3  . GLY A 1 179 ? -25.90893 -34.99652 8.07826   1.000 28.87632 ? 179 GLY A HA3  1 
ATOM   2713 N N    . ASN A 1 180 ? -26.92612 -32.55916 9.69960   1.000 24.34447 ? 180 ASN A N    1 
ATOM   2714 C CA   . ASN A 1 180 ? -27.62846 -31.28319 9.64555   1.000 24.10591 ? 180 ASN A CA   1 
ATOM   2715 C C    . ASN A 1 180 ? -26.64929 -30.14935 9.91960   1.000 22.43877 ? 180 ASN A C    1 
ATOM   2716 O O    . ASN A 1 180 ? -25.96102 -30.14690 10.94553  1.000 23.47073 ? 180 ASN A O    1 
ATOM   2717 C CB   . ASN A 1 180 ? -28.77384 -31.23918 10.65800  1.000 27.25532 ? 180 ASN A CB   1 
ATOM   2718 C CG   . ASN A 1 180 ? -29.69667 -32.43380 10.54630  1.000 27.62657 ? 180 ASN A CG   1 
ATOM   2719 O OD1  . ASN A 1 180 ? -30.52190 -32.51447 9.63431   1.000 33.35759 ? 180 ASN A OD1  1 
ATOM   2720 N ND2  . ASN A 1 180 ? -29.56941 -33.36733 11.48242  1.000 27.09262 ? 180 ASN A ND2  1 
ATOM   2721 H H    . ASN A 1 180 ? -26.90930 -32.91734 10.48128  1.000 29.23615 ? 180 ASN A H    1 
ATOM   2722 H HA   . ASN A 1 180 ? -28.00597 -31.16667 8.75965   1.000 28.94987 ? 180 ASN A HA   1 
ATOM   2723 H HB2  . ASN A 1 180 ? -28.40360 -31.22837 11.55450  1.000 32.72916 ? 180 ASN A HB2  1 
ATOM   2724 H HB3  . ASN A 1 180 ? -29.29960 -30.43823 10.50652  1.000 32.72916 ? 180 ASN A HB3  1 
ATOM   2725 H HD21 . ASN A 1 180 ? -30.07044 -34.06606 11.46382  1.000 32.53392 ? 180 ASN A HD21 1 
ATOM   2726 H HD22 . ASN A 1 180 ? -28.98598 -33.27307 12.10718  1.000 32.53392 ? 180 ASN A HD22 1 
ATOM   2727 N N    . PHE A 1 181 ? -26.59524 -29.18748 9.00419   1.000 24.36397 ? 181 PHE A N    1 
ATOM   2728 C CA   . PHE A 1 181 ? -25.70348 -28.05061 9.17296   1.000 23.62168 ? 181 PHE A CA   1 
ATOM   2729 C C    . PHE A 1 181 ? -26.07990 -27.24465 10.40638  1.000 26.63029 ? 181 PHE A C    1 
ATOM   2730 O O    . PHE A 1 181 ? -27.26033 -27.03560 10.70062  1.000 22.95126 ? 181 PHE A O    1 
ATOM   2731 C CB   . PHE A 1 181 ? -25.75101 -27.14809 7.93793   1.000 22.82147 ? 181 PHE A CB   1 
ATOM   2732 C CG   . PHE A 1 181 ? -24.61157 -27.36471 6.98581   1.000 22.73510 ? 181 PHE A CG   1 
ATOM   2733 C CD1  . PHE A 1 181 ? -23.39622 -26.72982 7.18928   1.000 24.25229 ? 181 PHE A CD1  1 
ATOM   2734 C CD2  . PHE A 1 181 ? -24.75080 -28.20363 5.89126   1.000 25.57562 ? 181 PHE A CD2  1 
ATOM   2735 C CE1  . PHE A 1 181 ? -22.33733 -26.92467 6.31914   1.000 23.88376 ? 181 PHE A CE1  1 
ATOM   2736 C CE2  . PHE A 1 181 ? -23.69397 -28.40499 5.01221   1.000 26.32323 ? 181 PHE A CE2  1 
ATOM   2737 C CZ   . PHE A 1 181 ? -22.48533 -27.76303 5.22759   1.000 25.62022 ? 181 PHE A CZ   1 
ATOM   2738 H H    . PHE A 1 181 ? -27.06176 -29.17060 8.28192   1.000 29.25954 ? 181 PHE A H    1 
ATOM   2739 H HA   . PHE A 1 181 ? -24.79713 -28.37811 9.28324   1.000 28.36880 ? 181 PHE A HA   1 
ATOM   2740 H HB2  . PHE A 1 181 ? -26.57546 -27.32096 7.45700   1.000 27.40854 ? 181 PHE A HB2  1 
ATOM   2741 H HB3  . PHE A 1 181 ? -25.72331 -26.22255 8.22690   1.000 27.40854 ? 181 PHE A HB3  1 
ATOM   2742 H HD1  . PHE A 1 181 ? -23.29074 -26.16506 7.92059   1.000 29.12553 ? 181 PHE A HD1  1 
ATOM   2743 H HD2  . PHE A 1 181 ? -25.56058 -28.63650 5.74367   1.000 30.71352 ? 181 PHE A HD2  1 
ATOM   2744 H HE1  . PHE A 1 181 ? -21.52725 -26.49273 6.46778   1.000 28.68329 ? 181 PHE A HE1  1 
ATOM   2745 H HE2  . PHE A 1 181 ? -23.79768 -28.96966 4.28056   1.000 31.61065 ? 181 PHE A HE2  1 
ATOM   2746 H HZ   . PHE A 1 181 ? -21.77590 -27.89486 4.64089   1.000 30.76704 ? 181 PHE A HZ   1 
ATOM   2747 N N    . TYR A 1 182 ? -25.06217 -26.80438 11.13771  1.000 21.65962 ? 182 TYR A N    1 
ATOM   2748 C CA   . TYR A 1 182 ? -25.23913 -25.69932 12.06562  1.000 22.30911 ? 182 TYR A CA   1 
ATOM   2749 C C    . TYR A 1 182 ? -25.34261 -24.41337 11.25852  1.000 21.87553 ? 182 TYR A C    1 
ATOM   2750 O O    . TYR A 1 182 ? -24.39852 -24.03841 10.55527  1.000 24.00594 ? 182 TYR A O    1 
ATOM   2751 C CB   . TYR A 1 182 ? -24.07274 -25.61613 13.04297  1.000 20.92730 ? 182 TYR A CB   1 
ATOM   2752 C CG   . TYR A 1 182 ? -24.01084 -26.71984 14.06813  1.000 21.78554 ? 182 TYR A CG   1 
ATOM   2753 C CD1  . TYR A 1 182 ? -24.69581 -26.61370 15.27137  1.000 27.60010 ? 182 TYR A CD1  1 
ATOM   2754 C CD2  . TYR A 1 182 ? -23.23973 -27.85170 13.84976  1.000 23.22010 ? 182 TYR A CD2  1 
ATOM   2755 C CE1  . TYR A 1 182 ? -24.62973 -27.61148 16.21882  1.000 27.61089 ? 182 TYR A CE1  1 
ATOM   2756 C CE2  . TYR A 1 182 ? -23.16707 -28.85693 14.79057  1.000 25.96712 ? 182 TYR A CE2  1 
ATOM   2757 C CZ   . TYR A 1 182 ? -23.86535 -28.73315 15.97411  1.000 23.22598 ? 182 TYR A CZ   1 
ATOM   2758 O OH   . TYR A 1 182 ? -23.79560 -29.73023 16.92138  1.000 23.84177 ? 182 TYR A OH   1 
ATOM   2759 H H    . TYR A 1 182 ? -24.26549 -27.12742 11.11401  1.000 26.01432 ? 182 TYR A H    1 
ATOM   2760 H HA   . TYR A 1 182 ? -26.04640 -25.83271 12.58660  1.000 26.79371 ? 182 TYR A HA   1 
ATOM   2761 H HB2  . TYR A 1 182 ? -23.24628 -25.64533 12.53600  1.000 25.13554 ? 182 TYR A HB2  1 
ATOM   2762 H HB3  . TYR A 1 182 ? -24.13684 -24.77676 13.52489  1.000 25.13554 ? 182 TYR A HB3  1 
ATOM   2763 H HD1  . TYR A 1 182 ? -25.20792 -25.85604 15.44047  1.000 33.14289 ? 182 TYR A HD1  1 
ATOM   2764 H HD2  . TYR A 1 182 ? -22.76353 -27.93404 13.05518  1.000 27.88690 ? 182 TYR A HD2  1 
ATOM   2765 H HE1  . TYR A 1 182 ? -25.09756 -27.52930 17.01837  1.000 33.15584 ? 182 TYR A HE1  1 
ATOM   2766 H HE2  . TYR A 1 182 ? -22.65086 -29.61335 14.62852  1.000 31.18332 ? 182 TYR A HE2  1 
ATOM   2767 H HH   . TYR A 1 182 ? -23.86618 -30.48187 16.55307  1.000 28.63290 ? 182 TYR A HH   1 
ATOM   2768 N N    . GLY A 1 183 ? -26.49309 -23.75729 11.32943  1.000 21.30703 ? 183 GLY A N    1 
ATOM   2769 C CA   . GLY A 1 183 ? -26.69082 -22.50284 10.64646  1.000 23.53466 ? 183 GLY A CA   1 
ATOM   2770 C C    . GLY A 1 183 ? -27.35765 -22.65365 9.29315   1.000 26.20872 ? 183 GLY A C    1 
ATOM   2771 O O    . GLY A 1 183 ? -27.79991 -23.73771 8.89928   1.000 25.34737 ? 183 GLY A O    1 
ATOM   2772 H H    . GLY A 1 183 ? -27.17838 -24.02674 11.77370  1.000 25.59121 ? 183 GLY A H    1 
ATOM   2773 H HA2  . GLY A 1 183 ? -27.24741 -21.92757 11.19433  1.000 28.26438 ? 183 GLY A HA2  1 
ATOM   2774 H HA3  . GLY A 1 183 ? -25.83043 -22.07539 10.51259  1.000 28.26438 ? 183 GLY A HA3  1 
ATOM   2775 N N    . PRO A 1 184 ? -27.43052 -21.54287 8.54650   1.000 24.13647 ? 184 PRO A N    1 
ATOM   2776 C CA   . PRO A 1 184 ? -28.16874 -21.49191 7.27946   1.000 29.66746 ? 184 PRO A CA   1 
ATOM   2777 C C    . PRO A 1 184 ? -27.31917 -21.83073 6.05520   1.000 29.87173 ? 184 PRO A C    1 
ATOM   2778 O O    . PRO A 1 184 ? -27.34532 -21.12513 5.03980   1.000 40.66828 ? 184 PRO A O    1 
ATOM   2779 C CB   . PRO A 1 184 ? -28.62888 -20.03331 7.22704   1.000 27.99376 ? 184 PRO A CB   1 
ATOM   2780 C CG   . PRO A 1 184 ? -27.43804 -19.31464 7.82023   1.000 27.69256 ? 184 PRO A CG   1 
ATOM   2781 C CD   . PRO A 1 184 ? -26.96495 -20.20547 8.95313   1.000 30.74438 ? 184 PRO A CD   1 
ATOM   2782 H HA   . PRO A 1 184 ? -28.92898 -22.09275 7.32338   1.000 35.62373 ? 184 PRO A HA   1 
ATOM   2783 H HB2  . PRO A 1 184 ? -28.79484 -19.75828 6.31178   1.000 33.61529 ? 184 PRO A HB2  1 
ATOM   2784 H HB3  . PRO A 1 184 ? -29.42805 -19.90592 7.76183   1.000 33.61529 ? 184 PRO A HB3  1 
ATOM   2785 H HG2  . PRO A 1 184 ? -26.74601 -19.21150 7.14839   1.000 33.25386 ? 184 PRO A HG2  1 
ATOM   2786 H HG3  . PRO A 1 184 ? -27.70924 -18.44495 8.15338   1.000 33.25386 ? 184 PRO A HG3  1 
ATOM   2787 H HD2  . PRO A 1 184 ? -25.99813 -20.18432 9.02872   1.000 36.91604 ? 184 PRO A HD2  1 
ATOM   2788 H HD3  . PRO A 1 184 ? -27.36934 -19.93958 9.79377   1.000 36.91604 ? 184 PRO A HD3  1 
ATOM   2789 N N    . PHE A 1 185 ? -26.55762 -22.91528 6.13769   1.000 25.56876 ? 185 PHE A N    1 
ATOM   2790 C CA   . PHE A 1 185 ? -25.56160 -23.23376 5.12716   1.000 25.90850 ? 185 PHE A CA   1 
ATOM   2791 C C    . PHE A 1 185 ? -25.91487 -24.53466 4.42291   1.000 24.07312 ? 185 PHE A C    1 
ATOM   2792 O O    . PHE A 1 185 ? -26.58571 -25.40774 4.98323   1.000 23.68188 ? 185 PHE A O    1 
ATOM   2793 C CB   . PHE A 1 185 ? -24.15839 -23.33132 5.74823   1.000 25.80834 ? 185 PHE A CB   1 
ATOM   2794 C CG   . PHE A 1 185 ? -23.82228 -22.17700 6.64435   1.000 22.11664 ? 185 PHE A CG   1 
ATOM   2795 C CD1  . PHE A 1 185 ? -23.62268 -20.90889 6.11838   1.000 24.00114 ? 185 PHE A CD1  1 
ATOM   2796 C CD2  . PHE A 1 185 ? -23.71951 -22.35518 8.01331   1.000 25.66680 ? 185 PHE A CD2  1 
ATOM   2797 C CE1  . PHE A 1 185 ? -23.32340 -19.83800 6.94323   1.000 26.51141 ? 185 PHE A CE1  1 
ATOM   2798 C CE2  . PHE A 1 185 ? -23.42031 -21.29044 8.84632   1.000 24.96539 ? 185 PHE A CE2  1 
ATOM   2799 C CZ   . PHE A 1 185 ? -23.22209 -20.02976 8.31236   1.000 23.80333 ? 185 PHE A CZ   1 
ATOM   2800 H H    . PHE A 1 185 ? -26.60135 -23.48757 6.77814   1.000 30.70528 ? 185 PHE A H    1 
ATOM   2801 H HA   . PHE A 1 185 ? -25.54958 -22.53426 4.45526   1.000 31.11298 ? 185 PHE A HA   1 
ATOM   2802 H HB2  . PHE A 1 185 ? -24.10527 -24.14327 6.27625   1.000 30.99279 ? 185 PHE A HB2  1 
ATOM   2803 H HB3  . PHE A 1 185 ? -23.50122 -23.35569 5.03519   1.000 30.99279 ? 185 PHE A HB3  1 
ATOM   2804 H HD1  . PHE A 1 185 ? -23.69076 -20.77651 5.20037   1.000 28.82415 ? 185 PHE A HD1  1 
ATOM   2805 H HD2  . PHE A 1 185 ? -23.85305 -23.20026 8.37788   1.000 30.82294 ? 185 PHE A HD2  1 
ATOM   2806 H HE1  . PHE A 1 185 ? -23.19068 -18.99231 6.57977   1.000 31.83646 ? 185 PHE A HE1  1 
ATOM   2807 H HE2  . PHE A 1 185 ? -23.35264 -21.42273 9.76437   1.000 29.98124 ? 185 PHE A HE2  1 
ATOM   2808 H HZ   . PHE A 1 185 ? -23.02150 -19.31317 8.87018   1.000 28.58677 ? 185 PHE A HZ   1 
ATOM   2809 N N    . VAL A 1 186 ? -25.46675 -24.63203 3.17347   1.000 23.52474 ? 186 VAL A N    1 
ATOM   2810 C CA   . VAL A 1 186 ? -25.60370 -25.82234 2.34715   1.000 24.07682 ? 186 VAL A CA   1 
ATOM   2811 C C    . VAL A 1 186 ? -24.22390 -26.18124 1.81724   1.000 24.21849 ? 186 VAL A C    1 
ATOM   2812 O O    . VAL A 1 186 ? -23.35253 -25.31729 1.67324   1.000 25.17064 ? 186 VAL A O    1 
ATOM   2813 C CB   . VAL A 1 186 ? -26.59514 -25.61131 1.18093   1.000 29.15773 ? 186 VAL A CB   1 
ATOM   2814 C CG1  . VAL A 1 186 ? -28.01203 -25.42561 1.71143   1.000 28.63261 ? 186 VAL A CG1  1 
ATOM   2815 C CG2  . VAL A 1 186 ? -26.17056 -24.42384 0.32249   1.000 27.41469 ? 186 VAL A CG2  1 
ATOM   2816 H H    . VAL A 1 186 ? -25.06211 -23.99151 2.76653   1.000 28.25246 ? 186 VAL A H    1 
ATOM   2817 H HA   . VAL A 1 186 ? -25.93604 -26.55645 2.88708   1.000 28.91496 ? 186 VAL A HA   1 
ATOM   2818 H HB   . VAL A 1 186 ? -26.58977 -26.40041 0.61684   1.000 35.01205 ? 186 VAL A HB   1 
ATOM   2819 H HG11 . VAL A 1 186 ? -28.49117 -24.81804 1.12646   1.000 34.38190 ? 186 VAL A HG11 1 
ATOM   2820 H HG12 . VAL A 1 186 ? -28.45763 -26.28700 1.73023   1.000 34.38190 ? 186 VAL A HG12 1 
ATOM   2821 H HG13 . VAL A 1 186 ? -27.96795 -25.05638 2.60732   1.000 34.38190 ? 186 VAL A HG13 1 
ATOM   2822 H HG21 . VAL A 1 186 ? -26.88181 -24.21643 -0.30361  1.000 32.92040 ? 186 VAL A HG21 1 
ATOM   2823 H HG22 . VAL A 1 186 ? -26.00408 -23.66129 0.89843   1.000 32.92040 ? 186 VAL A HG22 1 
ATOM   2824 H HG23 . VAL A 1 186 ? -25.36210 -24.65633 -0.16047  1.000 32.92040 ? 186 VAL A HG23 1 
ATOM   2825 N N    . ASP A 1 187 ? -24.02502 -27.46793 1.52540   1.000 22.89101 ? 187 ASP A N    1 
ATOM   2826 C CA   . ASP A 1 187 ? -22.73141 -27.94625 1.03207   1.000 23.20977 ? 187 ASP A CA   1 
ATOM   2827 C C    . ASP A 1 187 ? -22.67682 -27.82070 -0.49221  1.000 23.99228 ? 187 ASP A C    1 
ATOM   2828 O O    . ASP A 1 187 ? -22.63425 -28.79652 -1.24379  1.000 25.66977 ? 187 ASP A O    1 
ATOM   2829 C CB   . ASP A 1 187 ? -22.45848 -29.37337 1.50085   1.000 25.47100 ? 187 ASP A CB   1 
ATOM   2830 C CG   . ASP A 1 187 ? -23.62582 -30.31821 1.27791   1.000 25.18482 ? 187 ASP A CG   1 
ATOM   2831 O OD1  . ASP A 1 187 ? -24.72589 -29.86458 0.90038   1.000 28.22262 ? 187 ASP A OD1  1 
ATOM   2832 O OD2  . ASP A 1 187 ? -23.43007 -31.53372 1.49409   1.000 27.82033 ? 187 ASP A OD2  1 
ATOM   2833 H H    . ASP A 1 187 ? -24.62191 -28.08200 1.60441   1.000 27.49199 ? 187 ASP A H    1 
ATOM   2834 H HA   . ASP A 1 187 ? -22.03747 -27.37866 1.40246   1.000 27.87450 ? 187 ASP A HA   1 
ATOM   2835 H HB2  . ASP A 1 187 ? -21.69652 -29.72293 1.01288   1.000 30.58797 ? 187 ASP A HB2  1 
ATOM   2836 H HB3  . ASP A 1 187 ? -22.26561 -29.35924 2.45138   1.000 30.58797 ? 187 ASP A HB3  1 
ATOM   2837 N N    . ARG A 1 188 ? -22.66768 -26.56469 -0.93398  1.000 28.41604 ? 188 ARG A N    1 
ATOM   2838 C CA   . ARG A 1 188 ? -22.39964 -26.19055 -2.31438  1.000 29.93466 ? 188 ARG A CA   1 
ATOM   2839 C C    . ARG A 1 188 ? -21.38733 -25.05749 -2.29331  1.000 32.64408 ? 188 ARG A C    1 
ATOM   2840 O O    . ARG A 1 188 ? -21.50110 -24.13183 -1.48326  1.000 27.90380 ? 188 ARG A O    1 
ATOM   2841 C CB   . ARG A 1 188 ? -23.67442 -25.75400 -3.04745  1.000 32.77108 ? 188 ARG A CB   1 
ATOM   2842 H H    . ARG A 1 188 ? -22.82074 -25.88544 -0.42920  1.000 34.12203 ? 188 ARG A H    1 
ATOM   2843 H HA   . ARG A 1 188 ? -22.03519 -26.94243 -2.80708  1.000 35.94437 ? 188 ARG A HA   1 
ATOM   2844 N N    . GLN A 1 189 ? -20.38616 -25.14125 -3.16882  1.000 30.46149 ? 189 GLN A N    1 
ATOM   2845 C CA   . GLN A 1 189 ? -19.29409 -24.17020 -3.17108  1.000 32.02570 ? 189 GLN A CA   1 
ATOM   2846 C C    . GLN A 1 189 ? -19.78029 -22.92304 -3.90106  1.000 34.94353 ? 189 GLN A C    1 
ATOM   2847 O O    . GLN A 1 189 ? -19.48858 -22.68263 -5.07557  1.000 33.03761 ? 189 GLN A O    1 
ATOM   2848 C CB   . GLN A 1 189 ? -18.03854 -24.75310 -3.80321  1.000 33.45385 ? 189 GLN A CB   1 
ATOM   2849 C CG   . GLN A 1 189 ? -16.77419 -24.07143 -3.31192  1.000 32.93642 ? 189 GLN A CG   1 
ATOM   2850 C CD   . GLN A 1 189 ? -15.51842 -24.85830 -3.61467  1.000 34.87290 ? 189 GLN A CD   1 
ATOM   2851 O OE1  . GLN A 1 189 ? -15.47408 -26.07438 -3.43157  1.000 32.63576 ? 189 GLN A OE1  1 
ATOM   2852 N NE2  . GLN A 1 189 ? -14.48408 -24.16481 -4.07604  1.000 45.31453 ? 189 GLN A NE2  1 
ATOM   2853 H H    . GLN A 1 189 ? -20.31753 -25.75146 -3.77092  1.000 36.57657 ? 189 GLN A H    1 
ATOM   2854 H HA   . GLN A 1 189 ? -19.07374 -23.93114 -2.25719  1.000 38.45361 ? 189 GLN A HA   1 
ATOM   2855 H HB2  . GLN A 1 189 ? -17.97959 -25.69538 -3.58064  1.000 40.16740 ? 189 GLN A HB2  1 
ATOM   2856 H HB3  . GLN A 1 189 ? -18.08711 -24.64194 -4.76559  1.000 40.16740 ? 189 GLN A HB3  1 
ATOM   2857 H HG2  . GLN A 1 189 ? -16.69531 -23.20622 -3.74330  1.000 39.54648 ? 189 GLN A HG2  1 
ATOM   2858 H HG3  . GLN A 1 189 ? -16.83094 -23.95869 -2.35017  1.000 39.54648 ? 189 GLN A HG3  1 
ATOM   2859 H HE21 . GLN A 1 189 ? -14.55161 -23.31473 -4.18741  1.000 54.40022 ? 189 GLN A HE21 1 
ATOM   2860 H HE22 . GLN A 1 189 ? -13.74673 -24.56580 -4.26345  1.000 54.40022 ? 189 GLN A HE22 1 
ATOM   2861 N N    . THR A 1 190 ? -20.56312 -22.12922 -3.17644  1.000 29.86935 ? 190 THR A N    1 
ATOM   2862 C CA   . THR A 1 190 ? -21.08353 -20.86223 -3.65994  1.000 31.55870 ? 190 THR A CA   1 
ATOM   2863 C C    . THR A 1 190 ? -21.08707 -19.88556 -2.49297  1.000 33.51303 ? 190 THR A C    1 
ATOM   2864 O O    . THR A 1 190 ? -21.04984 -20.28548 -1.32643  1.000 30.39176 ? 190 THR A O    1 
ATOM   2865 C CB   . THR A 1 190 ? -22.49306 -21.01633 -4.25283  1.000 36.15067 ? 190 THR A CB   1 
ATOM   2866 O OG1  . THR A 1 190 ? -22.90546 -19.78200 -4.85220  1.000 39.99007 ? 190 THR A OG1  1 
ATOM   2867 C CG2  . THR A 1 190 ? -23.49074 -21.41286 -3.17668  1.000 34.34445 ? 190 THR A CG2  1 
ATOM   2868 H H    . THR A 1 190 ? -20.81375 -22.31177 -2.37428  1.000 35.86600 ? 190 THR A H    1 
ATOM   2869 H HA   . THR A 1 190 ? -20.51522 -20.50641 -4.36088  1.000 37.89322 ? 190 THR A HA   1 
ATOM   2870 H HB   . THR A 1 190 ? -22.48053 -21.71328 -4.92738  1.000 43.40359 ? 190 THR A HB   1 
ATOM   2871 H HG1  . THR A 1 190 ? -22.48482 -19.65567 -5.56824  1.000 48.01086 ? 190 THR A HG1  1 
ATOM   2872 H HG21 . THR A 1 190 ? -24.30901 -21.73558 -3.58557  1.000 41.23612 ? 190 THR A HG21 1 
ATOM   2873 H HG22 . THR A 1 190 ? -23.11799 -22.11541 -2.62136  1.000 41.23612 ? 190 THR A HG22 1 
ATOM   2874 H HG23 . THR A 1 190 ? -23.69845 -20.64723 -2.61850  1.000 41.23612 ? 190 THR A HG23 1 
ATOM   2875 N N    . ALA A 1 191 ? -21.13340 -18.59561 -2.81614  1.000 32.96633 ? 191 ALA A N    1 
ATOM   2876 C CA   . ALA A 1 191 ? -20.99177 -17.56705 -1.79332  1.000 31.16807 ? 191 ALA A CA   1 
ATOM   2877 C C    . ALA A 1 191 ? -22.16648 -17.61448 -0.82386  1.000 31.79786 ? 191 ALA A C    1 
ATOM   2878 O O    . ALA A 1 191 ? -23.32991 -17.56162 -1.23480  1.000 32.42192 ? 191 ALA A O    1 
ATOM   2879 C CB   . ALA A 1 191 ? -20.88707 -16.18651 -2.43864  1.000 28.85562 ? 191 ALA A CB   1 
ATOM   2880 H H    . ALA A 1 191 ? -21.24489 -18.29335 -3.61352  1.000 39.58237 ? 191 ALA A H    1 
ATOM   2881 H HA   . ALA A 1 191 ? -20.17823 -17.72724 -1.28994  1.000 37.42446 ? 191 ALA A HA   1 
ATOM   2882 H HB1  . ALA A 1 191 ? -20.78745 -15.51898 -1.74194  1.000 34.64953 ? 191 ALA A HB1  1 
ATOM   2883 H HB2  . ALA A 1 191 ? -20.11488 -16.16995 -3.02545  1.000 34.64953 ? 191 ALA A HB2  1 
ATOM   2884 H HB3  . ALA A 1 191 ? -21.69393 -16.01434 -2.94876  1.000 34.64953 ? 191 ALA A HB3  1 
ATOM   2885 N N    . GLN A 1 192 ? -21.85502 -17.71252 0.46811   1.000 30.22265 ? 192 GLN A N    1 
ATOM   2886 C CA   . GLN A 1 192 ? -22.85741 -17.82778 1.51662   1.000 30.29672 ? 192 GLN A CA   1 
ATOM   2887 C C    . GLN A 1 192 ? -22.46349 -16.94031 2.68663   1.000 31.19134 ? 192 GLN A C    1 
ATOM   2888 O O    . GLN A 1 192 ? -21.28321 -16.84939 3.03614   1.000 32.49652 ? 192 GLN A O    1 
ATOM   2889 C CB   . GLN A 1 192 ? -23.00474 -19.28056 1.98360   1.000 26.22548 ? 192 GLN A CB   1 
ATOM   2890 C CG   . GLN A 1 192 ? -23.55439 -20.21483 0.92124   1.000 30.96393 ? 192 GLN A CG   1 
ATOM   2891 C CD   . GLN A 1 192 ? -23.55902 -21.66443 1.36407   1.000 28.06101 ? 192 GLN A CD   1 
ATOM   2892 O OE1  . GLN A 1 192 ? -24.16464 -22.01540 2.37650   1.000 26.14372 ? 192 GLN A OE1  1 
ATOM   2893 N NE2  . GLN A 1 192 ? -22.87738 -22.51513 0.60704   1.000 28.98917 ? 192 GLN A NE2  1 
ATOM   2894 H H    . GLN A 1 192 ? -21.04838 -17.71425 0.76634   1.000 36.28996 ? 192 GLN A H    1 
ATOM   2895 H HA   . GLN A 1 192 ? -23.71732 -17.52543 1.18489   1.000 36.37884 ? 192 GLN A HA   1 
ATOM   2896 H HB2  . GLN A 1 192 ? -22.13230 -19.61293 2.24681   1.000 31.49335 ? 192 GLN A HB2  1 
ATOM   2897 H HB3  . GLN A 1 192 ? -23.61098 -19.30430 2.74044   1.000 31.49335 ? 192 GLN A HB3  1 
ATOM   2898 H HG2  . GLN A 1 192 ? -24.46793 -19.96004 0.71772   1.000 37.17949 ? 192 GLN A HG2  1 
ATOM   2899 H HG3  . GLN A 1 192 ? -23.00541 -20.14594 0.12451   1.000 37.17949 ? 192 GLN A HG3  1 
ATOM   2900 H HE21 . GLN A 1 192 ? -22.46402 -22.23254 -0.09216  1.000 34.80978 ? 192 GLN A HE21 1 
ATOM   2901 H HE22 . GLN A 1 192 ? -22.84904 -23.34895 0.81569   1.000 34.80978 ? 192 GLN A HE22 1 
ATOM   2902 N N    . ALA A 1 193 ? -23.45838 -16.30037 3.29505   1.000 32.22134 ? 193 ALA A N    1 
ATOM   2903 C CA   . ALA A 1 193 ? -23.24537 -15.31917 4.35082   1.000 30.18743 ? 193 ALA A CA   1 
ATOM   2904 C C    . ALA A 1 193 ? -23.70258 -15.87943 5.69049   1.000 33.15705 ? 193 ALA A C    1 
ATOM   2905 O O    . ALA A 1 193 ? -24.81643 -16.40302 5.80280   1.000 30.08825 ? 193 ALA A O    1 
ATOM   2906 C CB   . ALA A 1 193 ? -23.99694 -14.02162 4.04364   1.000 33.39950 ? 193 ALA A CB   1 
ATOM   2907 H H    . ALA A 1 193 ? -24.28859 -16.42251 3.10680   1.000 38.68839 ? 193 ALA A H    1 
ATOM   2908 H HA   . ALA A 1 193 ? -22.29701 -15.12630 4.41646   1.000 36.24770 ? 193 ALA A HA   1 
ATOM   2909 H HB1  . ALA A 1 193 ? -23.88300 -13.40742 4.78572   1.000 40.10218 ? 193 ALA A HB1  1 
ATOM   2910 H HB2  . ALA A 1 193 ? -23.63496 -13.63140 3.23272   1.000 40.10218 ? 193 ALA A HB2  1 
ATOM   2911 H HB3  . ALA A 1 193 ? -24.93804 -14.22290 3.92236   1.000 40.10218 ? 193 ALA A HB3  1 
ATOM   2912 N N    . ALA A 1 194 ? -22.84166 -15.75654 6.70480   1.000 33.08852 ? 194 ALA A N    1 
ATOM   2913 C CA   . ALA A 1 194 ? -23.18522 -16.18025 8.05647   1.000 34.20416 ? 194 ALA A CA   1 
ATOM   2914 C C    . ALA A 1 194 ? -23.99416 -15.13565 8.81040   1.000 39.56907 ? 194 ALA A C    1 
ATOM   2915 O O    . ALA A 1 194 ? -24.65505 -15.47678 9.79834   1.000 34.74993 ? 194 ALA A O    1 
ATOM   2916 C CB   . ALA A 1 194 ? -21.91460 -16.50118 8.84962   1.000 35.94823 ? 194 ALA A CB   1 
ATOM   2917 H H    . ALA A 1 194 ? -22.04977 -15.42903 6.63236   1.000 39.72900 ? 194 ALA A H    1 
ATOM   2918 H HA   . ALA A 1 194 ? -23.71686 -16.98944 7.99759   1.000 41.06777 ? 194 ALA A HA   1 
ATOM   2919 H HB1  . ALA A 1 194 ? -21.33678 -15.72206 8.84912   1.000 43.16065 ? 194 ALA A HB1  1 
ATOM   2920 H HB2  . ALA A 1 194 ? -22.15986 -16.73053 9.75964   1.000 43.16065 ? 194 ALA A HB2  1 
ATOM   2921 H HB3  . ALA A 1 194 ? -21.46132 -17.24943 8.43062   1.000 43.16065 ? 194 ALA A HB3  1 
ATOM   2922 N N    . GLY A 1 195 ? -23.96725 -13.88112 8.37263   1.000 31.12683 ? 195 GLY A N    1 
ATOM   2923 C CA   . GLY A 1 195 ? -24.66706 -12.82999 9.07537   1.000 36.39156 ? 195 GLY A CA   1 
ATOM   2924 C C    . GLY A 1 195 ? -23.85836 -12.29701 10.24066  1.000 36.12175 ? 195 GLY A C    1 
ATOM   2925 O O    . GLY A 1 195 ? -22.78926 -12.80006 10.59253  1.000 32.13706 ? 195 GLY A O    1 
ATOM   2926 H H    . GLY A 1 195 ? -23.54797 -13.61942 7.66884   1.000 37.37498 ? 195 GLY A H    1 
ATOM   2927 H HA2  . GLY A 1 195 ? -24.84782 -12.09792 8.46521   1.000 43.69265 ? 195 GLY A HA2  1 
ATOM   2928 H HA3  . GLY A 1 195 ? -25.50837 -13.17286 9.41528   1.000 43.69265 ? 195 GLY A HA3  1 
ATOM   2929 N N    . THR A 1 196 ? -24.39703 -11.24832 10.85572  1.000 33.06038 ? 196 THR A N    1 
ATOM   2930 C CA   . THR A 1 196 ? -23.68796 -10.56537 11.92816  1.000 33.25547 ? 196 THR A CA   1 
ATOM   2931 C C    . THR A 1 196 ? -23.36287 -11.52642 13.06383  1.000 33.24251 ? 196 THR A C    1 
ATOM   2932 O O    . THR A 1 196 ? -24.23180 -12.25810 13.54873  1.000 32.60069 ? 196 THR A O    1 
ATOM   2933 C CB   . THR A 1 196 ? -24.52302 -9.40056  12.45757  1.000 37.12420 ? 196 THR A CB   1 
ATOM   2934 O OG1  . THR A 1 196 ? -24.90570 -8.55467  11.36808  1.000 33.34378 ? 196 THR A OG1  1 
ATOM   2935 C CG2  . THR A 1 196 ? -23.72225 -8.59857  13.47722  1.000 40.99352 ? 196 THR A CG2  1 
ATOM   2936 H H    . THR A 1 196 ? -25.16799 -10.91501 10.67098  1.000 39.69523 ? 196 THR A H    1 
ATOM   2937 H HA   . THR A 1 196 ? -22.85482 -10.21459 11.57642  1.000 39.92935 ? 196 THR A HA   1 
ATOM   2938 H HB   . THR A 1 196 ? -25.32079 -9.73734  12.89466  1.000 44.57181 ? 196 THR A HB   1 
ATOM   2939 H HG1  . THR A 1 196 ? -25.37623 -8.98533  10.82152  1.000 40.03531 ? 196 THR A HG1  1 
ATOM   2940 H HG21 . THR A 1 196 ? -24.10839 -7.71487  13.58143  1.000 49.21500 ? 196 THR A HG21 1 
ATOM   2941 H HG22 . THR A 1 196 ? -23.73218 -9.04970  14.33587  1.000 49.21500 ? 196 THR A HG22 1 
ATOM   2942 H HG23 . THR A 1 196 ? -22.80339 -8.50756  13.18004  1.000 49.21500 ? 196 THR A HG23 1 
ATOM   2943 N N    . ASP A 1 197 ? -22.10211 -11.52976 13.47983  1.000 30.44205 ? 197 ASP A N    1 
ATOM   2944 C CA   . ASP A 1 197 ? -21.70170 -12.26596 14.66515  1.000 38.54382 ? 197 ASP A CA   1 
ATOM   2945 C C    . ASP A 1 197 ? -21.79064 -11.35223 15.87832  1.000 38.82639 ? 197 ASP A C    1 
ATOM   2946 O O    . ASP A 1 197 ? -21.63896 -10.13104 15.77912  1.000 42.51533 ? 197 ASP A O    1 
ATOM   2947 C CB   . ASP A 1 197 ? -20.28085 -12.81501 14.53286  1.000 35.26677 ? 197 ASP A CB   1 
ATOM   2948 C CG   . ASP A 1 197 ? -20.01891 -13.98765 15.46885  1.000 36.78813 ? 197 ASP A CG   1 
ATOM   2949 O OD1  . ASP A 1 197 ? -20.99594 -14.61842 15.93655  1.000 30.26108 ? 197 ASP A OD1  1 
ATOM   2950 O OD2  . ASP A 1 197 ? -18.83625 -14.27454 15.74452  1.000 33.34059 ? 197 ASP A OD2  1 
ATOM   2951 H H    . ASP A 1 197 ? -21.46017 -11.11119 13.08955  1.000 36.55323 ? 197 ASP A H    1 
ATOM   2952 H HA   . ASP A 1 197 ? -22.29165 -13.02585 14.78938  1.000 46.27536 ? 197 ASP A HA   1 
ATOM   2953 H HB2  . ASP A 1 197 ? -20.14231 -13.11987 13.62249  1.000 42.34290 ? 197 ASP A HB2  1 
ATOM   2954 H HB3  . ASP A 1 197 ? -19.64804 -12.11177 14.74715  1.000 42.34290 ? 197 ASP A HB3  1 
ATOM   2955 N N    . THR A 1 198 ? -22.04381 -11.95929 17.02731  1.000 32.84870 ? 198 THR A N    1 
ATOM   2956 C CA   . THR A 1 198 ? -22.17545 -11.23836 18.28041  1.000 31.48265 ? 198 THR A CA   1 
ATOM   2957 C C    . THR A 1 198 ? -21.32513 -11.92749 19.33506  1.000 31.50252 ? 198 THR A C    1 
ATOM   2958 O O    . THR A 1 198 ? -21.07255 -13.13355 19.26206  1.000 27.50909 ? 198 THR A O    1 
ATOM   2959 C CB   . THR A 1 198 ? -23.64183 -11.16584 18.72936  1.000 39.09601 ? 198 THR A CB   1 
ATOM   2960 O OG1  . THR A 1 198 ? -24.21765 -12.47720 18.70582  1.000 42.15802 ? 198 THR A OG1  1 
ATOM   2961 C CG2  . THR A 1 198 ? -24.43871 -10.24766 17.80203  1.000 41.23706 ? 198 THR A CG2  1 
ATOM   2962 H H    . THR A 1 198 ? -22.14587 -12.80943 17.10760  1.000 39.44121 ? 198 THR A H    1 
ATOM   2963 H HA   . THR A 1 198 ? -21.85450 -10.32816 18.18326  1.000 37.80196 ? 198 THR A HA   1 
ATOM   2964 H HB   . THR A 1 198 ? -23.68766 -10.80920 19.63025  1.000 46.93800 ? 198 THR A HB   1 
ATOM   2965 H HG1  . THR A 1 198 ? -24.30626 -12.73786 17.91221  1.000 50.61240 ? 198 THR A HG1  1 
ATOM   2966 H HG21 . THR A 1 198 ? -24.39266 -10.57590 16.89042  1.000 49.50725 ? 198 THR A HG21 1 
ATOM   2967 H HG22 . THR A 1 198 ? -25.36756 -10.22034 18.08023  1.000 49.50725 ? 198 THR A HG22 1 
ATOM   2968 H HG23 . THR A 1 198 ? -24.07461 -9.34908  17.83184  1.000 49.50725 ? 198 THR A HG23 1 
ATOM   2969 N N    . THR A 1 199 ? -20.87578 -11.14462 20.31038  1.000 26.58421 ? 199 THR A N    1 
ATOM   2970 C CA   . THR A 1 199 ? -19.97686 -11.65010 21.33727  1.000 30.01103 ? 199 THR A CA   1 
ATOM   2971 C C    . THR A 1 199 ? -20.75979 -12.38265 22.41801  1.000 29.23318 ? 199 THR A C    1 
ATOM   2972 O O    . THR A 1 199 ? -21.84521 -11.95407 22.82150  1.000 30.01925 ? 199 THR A O    1 
ATOM   2973 C CB   . THR A 1 199 ? -19.17323 -10.50668 21.95624  1.000 31.19450 ? 199 THR A CB   1 
ATOM   2974 O OG1  . THR A 1 199 ? -18.48637 -9.79173  20.92157  1.000 28.25087 ? 199 THR A OG1  1 
ATOM   2975 C CG2  . THR A 1 199 ? -18.15718 -11.04937 22.95499  1.000 30.19703 ? 199 THR A CG2  1 
ATOM   2976 H H    . THR A 1 199 ? -21.07835 -10.31352 20.39895  1.000 31.92383 ? 199 THR A H    1 
ATOM   2977 H HA   . THR A 1 199 ? -19.35229 -12.27550 20.93766  1.000 36.03601 ? 199 THR A HA   1 
ATOM   2978 H HB   . THR A 1 199 ? -19.77168 -9.90406  22.42486  1.000 37.45618 ? 199 THR A HB   1 
ATOM   2979 H HG1  . THR A 1 199 ? -19.03865 -9.49218  20.36402  1.000 33.92382 ? 199 THR A HG1  1 
ATOM   2980 H HG21 . THR A 1 199 ? -18.53274 -11.03874 23.84927  1.000 36.25922 ? 199 THR A HG21 1 
ATOM   2981 H HG22 . THR A 1 199 ? -17.91945 -11.96103 22.72421  1.000 36.25922 ? 199 THR A HG22 1 
ATOM   2982 H HG23 . THR A 1 199 ? -17.35604 -10.50261 22.94349  1.000 36.25922 ? 199 THR A HG23 1 
ATOM   2983 N N    . ILE A 1 200 ? -20.19577 -13.49601 22.88381  1.000 27.20863 ? 200 ILE A N    1 
ATOM   2984 C CA   . ILE A 1 200 ? -20.85098 -14.36447 23.85522  1.000 26.64965 ? 200 ILE A CA   1 
ATOM   2985 C C    . ILE A 1 200 ? -20.66748 -13.76333 25.24294  1.000 27.20880 ? 200 ILE A C    1 
ATOM   2986 O O    . ILE A 1 200 ? -19.68080 -14.04730 25.93268  1.000 21.72162 ? 200 ILE A O    1 
ATOM   2987 C CB   . ILE A 1 200 ? -20.29347 -15.79780 23.78160  1.000 23.89043 ? 200 ILE A CB   1 
ATOM   2988 C CG1  . ILE A 1 200 ? -20.35361 -16.31705 22.34231  1.000 27.71111 ? 200 ILE A CG1  1 
ATOM   2989 C CG2  . ILE A 1 200 ? -21.08734 -16.72316 24.69906  1.000 25.14762 ? 200 ILE A CG2  1 
ATOM   2990 C CD1  . ILE A 1 200 ? -19.51354 -17.56086 22.09233  1.000 25.58098 ? 200 ILE A CD1  1 
ATOM   2991 H H    . ILE A 1 200 ? -19.41748 -13.77454 22.64656  1.000 32.67314 ? 200 ILE A H    1 
ATOM   2992 H HA   . ILE A 1 200 ? -21.80114 -14.40871 23.66511  1.000 32.00235 ? 200 ILE A HA   1 
ATOM   2993 H HB   . ILE A 1 200 ? -19.36844 -15.78011 24.07298  1.000 28.69129 ? 200 ILE A HB   1 
ATOM   2994 H HG12 . ILE A 1 200 ? -21.27431 -16.53636 22.12991  1.000 33.27611 ? 200 ILE A HG12 1 
ATOM   2995 H HG13 . ILE A 1 200 ? -20.03273 -15.62099 21.74780  1.000 33.27611 ? 200 ILE A HG13 1 
ATOM   2996 H HG21 . ILE A 1 200 ? -21.03663 -16.38677 25.60745  1.000 30.19993 ? 200 ILE A HG21 1 
ATOM   2997 H HG22 . ILE A 1 200 ? -22.01140 -16.74293 24.40475  1.000 30.19993 ? 200 ILE A HG22 1 
ATOM   2998 H HG23 . ILE A 1 200 ? -20.70690 -17.61434 24.65462  1.000 30.19993 ? 200 ILE A HG23 1 
ATOM   2999 H HD11 . ILE A 1 200 ? -18.61936 -17.29071 21.83085  1.000 30.71995 ? 200 ILE A HD11 1 
ATOM   3000 H HD12 . ILE A 1 200 ? -19.47555 -18.08535 22.90741  1.000 30.71995 ? 200 ILE A HD12 1 
ATOM   3001 H HD13 . ILE A 1 200 ? -19.92264 -18.08095 21.38307  1.000 30.71995 ? 200 ILE A HD13 1 
ATOM   3002 N N    . THR A 1 201 ? -21.62636 -12.93183 25.65782  1.000 27.06623 ? 201 THR A N    1 
ATOM   3003 C CA   . THR A 1 201 ? -21.46821 -12.14075 26.87527  1.000 26.56327 ? 201 THR A CA   1 
ATOM   3004 C C    . THR A 1 201 ? -21.13658 -13.01585 28.08153  1.000 26.08081 ? 201 THR A C    1 
ATOM   3005 O O    . THR A 1 201 ? -20.23332 -12.69744 28.86346  1.000 25.95855 ? 201 THR A O    1 
ATOM   3006 C CB   . THR A 1 201 ? -22.74180 -11.33071 27.13823  1.000 30.58997 ? 201 THR A CB   1 
ATOM   3007 O OG1  . THR A 1 201 ? -23.07742 -10.56120 25.97516  1.000 24.27622 ? 201 THR A OG1  1 
ATOM   3008 C CG2  . THR A 1 201 ? -22.54835 -10.38016 28.32456  1.000 30.08640 ? 201 THR A CG2  1 
ATOM   3009 H H    . THR A 1 201 ? -22.37501 -12.80877 25.25287  1.000 32.50226 ? 201 THR A H    1 
ATOM   3010 H HA   . THR A 1 201 ? -20.73060 -11.52439 26.74517  1.000 31.89871 ? 201 THR A HA   1 
ATOM   3011 H HB   . THR A 1 201 ? -23.46641 -11.94086 27.34695  1.000 36.73074 ? 201 THR A HB   1 
ATOM   3012 H HG1  . THR A 1 201 ? -22.85112 -10.97634 25.28086  1.000 29.15425 ? 201 THR A HG1  1 
ATOM   3013 H HG21 . THR A 1 201 ? -23.40937 -10.06430 28.64043  1.000 36.12645 ? 201 THR A HG21 1 
ATOM   3014 H HG22 . THR A 1 201 ? -22.09710 -10.84121 29.04894  1.000 36.12645 ? 201 THR A HG22 1 
ATOM   3015 H HG23 . THR A 1 201 ? -22.01293 -9.61763  28.05482  1.000 36.12645 ? 201 THR A HG23 1 
ATOM   3016 N N    . VAL A 1 202 ? -21.86686 -14.11904 28.26144  1.000 24.70686 ? 202 VAL A N    1 
ATOM   3017 C CA   . VAL A 1 202 ? -21.66423 -14.93159 29.45868  1.000 23.11557 ? 202 VAL A CA   1 
ATOM   3018 C C    . VAL A 1 202 ? -20.25199 -15.50236 29.49059  1.000 26.89456 ? 202 VAL A C    1 
ATOM   3019 O O    . VAL A 1 202 ? -19.68001 -15.70874 30.56852  1.000 22.30136 ? 202 VAL A O    1 
ATOM   3020 C CB   . VAL A 1 202 ? -22.73030 -16.04312 29.54208  1.000 26.62713 ? 202 VAL A CB   1 
ATOM   3021 C CG1  . VAL A 1 202 ? -22.51632 -17.09127 28.45337  1.000 30.22150 ? 202 VAL A CG1  1 
ATOM   3022 C CG2  . VAL A 1 202 ? -22.71615 -16.68157 30.92335  1.000 28.58920 ? 202 VAL A CG2  1 
ATOM   3023 H H    . VAL A 1 202 ? -22.46868 -14.40974 27.72024  1.000 29.67101 ? 202 VAL A H    1 
ATOM   3024 H HA   . VAL A 1 202 ? -21.77113 -14.36220 30.23668  1.000 27.76147 ? 202 VAL A HA   1 
ATOM   3025 H HB   . VAL A 1 202 ? -23.60485 -15.64930 29.39728  1.000 31.97533 ? 202 VAL A HB   1 
ATOM   3026 H HG11 . VAL A 1 202 ? -22.01677 -16.69174 27.72417  1.000 36.28857 ? 202 VAL A HG11 1 
ATOM   3027 H HG12 . VAL A 1 202 ? -22.01922 -17.83637 28.82568  1.000 36.28857 ? 202 VAL A HG12 1 
ATOM   3028 H HG13 . VAL A 1 202 ? -23.38014 -17.39628 28.13450  1.000 36.28857 ? 202 VAL A HG13 1 
ATOM   3029 H HG21 . VAL A 1 202 ? -23.45265 -17.30943 30.98860  1.000 34.32982 ? 202 VAL A HG21 1 
ATOM   3030 H HG22 . VAL A 1 202 ? -21.87366 -17.14585 31.04804  1.000 34.32982 ? 202 VAL A HG22 1 
ATOM   3031 H HG23 . VAL A 1 202 ? -22.81334 -15.98690 31.59335  1.000 34.32982 ? 202 VAL A HG23 1 
ATOM   3032 N N    . ASN A 1 203 ? -19.65897 -15.74767 28.31994  1.000 20.57068 ? 203 ASN A N    1 
ATOM   3033 C CA   . ASN A 1 203 ? -18.30063 -16.28020 28.27370  1.000 22.61927 ? 203 ASN A CA   1 
ATOM   3034 C C    . ASN A 1 203 ? -17.27002 -15.20948 28.61281  1.000 20.94737 ? 203 ASN A C    1 
ATOM   3035 O O    . ASN A 1 203 ? -16.25793 -15.49818 29.26303  1.000 21.70547 ? 203 ASN A O    1 
ATOM   3036 C CB   . ASN A 1 203 ? -18.01627 -16.86713 26.89178  1.000 23.95397 ? 203 ASN A CB   1 
ATOM   3037 C CG   . ASN A 1 203 ? -18.78929 -18.14290 26.62313  1.000 28.56362 ? 203 ASN A CG   1 
ATOM   3038 O OD1  . ASN A 1 203 ? -19.63170 -18.56218 27.42048  1.000 24.98812 ? 203 ASN A OD1  1 
ATOM   3039 N ND2  . ASN A 1 203 ? -18.50974 -18.76568 25.48458  1.000 25.02832 ? 203 ASN A ND2  1 
ATOM   3040 H H    . ASN A 1 203 ? -20.01754 -15.61582 27.54946  1.000 24.70760 ? 203 ASN A H    1 
ATOM   3041 H HA   . ASN A 1 203 ? -18.22516 -16.99053 28.92993  1.000 27.16591 ? 203 ASN A HA   1 
ATOM   3042 H HB2  . ASN A 1 203 ? -18.26570 -16.21786 26.21566  1.000 28.76754 ? 203 ASN A HB2  1 
ATOM   3043 H HB3  . ASN A 1 203 ? -17.07023 -17.07026 26.82367  1.000 28.76754 ? 203 ASN A HB3  1 
ATOM   3044 H HD21 . ASN A 1 203 ? -18.91880 -19.49435 25.28136  1.000 30.05676 ? 203 ASN A HD21 1 
ATOM   3045 H HD22 . ASN A 1 203 ? -17.91958 -18.44045 24.95022  1.000 30.05676 ? 203 ASN A HD22 1 
ATOM   3046 N N    . VAL A 1 204 ? -17.49394 -13.97207 28.16596  1.000 24.27013 ? 204 VAL A N    1 
ATOM   3047 C CA   . VAL A 1 204 ? -16.59201 -12.88771 28.54302  1.000 21.85237 ? 204 VAL A CA   1 
ATOM   3048 C C    . VAL A 1 204 ? -16.56805 -12.73476 30.05878  1.000 23.94227 ? 204 VAL A C    1 
ATOM   3049 O O    . VAL A 1 204 ? -15.50234 -12.57390 30.66715  1.000 20.50874 ? 204 VAL A O    1 
ATOM   3050 C CB   . VAL A 1 204 ? -17.00239 -11.57830 27.84143  1.000 23.75725 ? 204 VAL A CB   1 
ATOM   3051 C CG1  . VAL A 1 204 ? -16.09688 -10.43257 28.27206  1.000 22.23737 ? 204 VAL A CG1  1 
ATOM   3052 C CG2  . VAL A 1 204 ? -16.95831 -11.75165 26.32917  1.000 22.99464 ? 204 VAL A CG2  1 
ATOM   3053 H H    . VAL A 1 204 ? -18.14603 -13.74063 27.65527  1.000 29.14694 ? 204 VAL A H    1 
ATOM   3054 H HA   . VAL A 1 204 ? -15.69505 -13.10933 28.24762  1.000 26.24562 ? 204 VAL A HA   1 
ATOM   3055 H HB   . VAL A 1 204 ? -17.91133 -11.35738 28.09817  1.000 28.53148 ? 204 VAL A HB   1 
ATOM   3056 H HG11 . VAL A 1 204 ? -15.20185 -10.77594 28.42015  1.000 26.70762 ? 204 VAL A HG11 1 
ATOM   3057 H HG12 . VAL A 1 204 ? -16.08204 -9.76145  27.57186  1.000 26.70762 ? 204 VAL A HG12 1 
ATOM   3058 H HG13 . VAL A 1 204 ? -16.44328 -10.04738 29.09215  1.000 26.70762 ? 204 VAL A HG13 1 
ATOM   3059 H HG21 . VAL A 1 204 ? -17.12385 -10.89369 25.90800  1.000 27.61634 ? 204 VAL A HG21 1 
ATOM   3060 H HG22 . VAL A 1 204 ? -16.08243 -12.08164 26.07453  1.000 27.61634 ? 204 VAL A HG22 1 
ATOM   3061 H HG23 . VAL A 1 204 ? -17.64123 -12.38749 26.06416  1.000 27.61634 ? 204 VAL A HG23 1 
ATOM   3062 N N    . LEU A 1 205 ? -17.73952 -12.81830 30.69558  1.000 20.72601 ? 205 LEU A N    1 
ATOM   3063 C CA   . LEU A 1 205 ? -17.80972 -12.66226 32.14520  1.000 22.76489 ? 205 LEU A CA   1 
ATOM   3064 C C    . LEU A 1 205 ? -17.07346 -13.79414 32.84882  1.000 23.67376 ? 205 LEU A C    1 
ATOM   3065 O O    . LEU A 1 205 ? -16.36060 -13.56568 33.83400  1.000 24.26073 ? 205 LEU A O    1 
ATOM   3066 C CB   . LEU A 1 205 ? -19.27483 -12.59871 32.58789  1.000 21.99999 ? 205 LEU A CB   1 
ATOM   3067 C CG   . LEU A 1 205 ? -20.03724 -11.39468 32.02694  1.000 26.37343 ? 205 LEU A CG   1 
ATOM   3068 C CD1  . LEU A 1 205 ? -21.53554 -11.50648 32.28653  1.000 32.03554 ? 205 LEU A CD1  1 
ATOM   3069 C CD2  . LEU A 1 205 ? -19.49183 -10.10225 32.62132  1.000 26.50179 ? 205 LEU A CD2  1 
ATOM   3070 H H    . LEU A 1 205 ? -18.49707 -12.96273 30.31499  1.000 24.89398 ? 205 LEU A H    1 
ATOM   3071 H HA   . LEU A 1 205 ? -17.38638 -11.82794 32.40131  1.000 27.34065 ? 205 LEU A HA   1 
ATOM   3072 H HB2  . LEU A 1 205 ? -19.72618 -13.40256 32.28622  1.000 26.42276 ? 205 LEU A HB2  1 
ATOM   3073 H HB3  . LEU A 1 205 ? -19.30533 -12.54454 33.55590  1.000 26.42276 ? 205 LEU A HB3  1 
ATOM   3074 H HG   . LEU A 1 205 ? -19.91134 -11.37486 31.06535  1.000 31.67090 ? 205 LEU A HG   1 
ATOM   3075 H HD11 . LEU A 1 205 ? -21.99693 -10.82631 31.77137  1.000 38.46542 ? 205 LEU A HD11 1 
ATOM   3076 H HD12 . LEU A 1 205 ? -21.83792 -12.38775 32.01662  1.000 38.46542 ? 205 LEU A HD12 1 
ATOM   3077 H HD13 . LEU A 1 205 ? -21.70277 -11.37487 33.23290  1.000 38.46542 ? 205 LEU A HD13 1 
ATOM   3078 H HD21 . LEU A 1 205 ? -18.59249 -9.95642  32.28845  1.000 31.82493 ? 205 LEU A HD21 1 
ATOM   3079 H HD22 . LEU A 1 205 ? -20.06575 -9.36626  32.35706  1.000 31.82493 ? 205 LEU A HD22 1 
ATOM   3080 H HD23 . LEU A 1 205 ? -19.47811 -10.18038 33.58807  1.000 31.82493 ? 205 LEU A HD23 1 
ATOM   3081 N N    . ALA A 1 206 ? -17.21353 -15.02051 32.34142  1.000 23.62374 ? 206 ALA A N    1 
ATOM   3082 C CA   . ALA A 1 206 ? -16.50498 -16.14749 32.93746  1.000 23.43812 ? 206 ALA A CA   1 
ATOM   3083 C C    . ALA A 1 206 ? -14.99712 -15.95129 32.84999  1.000 25.76360 ? 206 ALA A C    1 
ATOM   3084 O O    . ALA A 1 206 ? -14.25989 -16.29141 33.78348  1.000 25.26092 ? 206 ALA A O    1 
ATOM   3085 C CB   . ALA A 1 206 ? -16.91384 -17.45055 32.24841  1.000 28.11547 ? 206 ALA A CB   1 
ATOM   3086 H H    . ALA A 1 206 ? -17.70445 -15.22150 31.66451  1.000 28.37127 ? 206 ALA A H    1 
ATOM   3087 H HA   . ALA A 1 206 ? -16.75085 -16.21286 33.87350  1.000 28.14852 ? 206 ALA A HA   1 
ATOM   3088 H HB1  . ALA A 1 206 ? -16.53669 -18.19836 32.73774  1.000 33.76134 ? 206 ALA A HB1  1 
ATOM   3089 H HB2  . ALA A 1 206 ? -17.88174 -17.51403 32.24170  1.000 33.76134 ? 206 ALA A HB2  1 
ATOM   3090 H HB3  . ALA A 1 206 ? -16.57632 -17.44631 31.33904  1.000 33.76134 ? 206 ALA A HB3  1 
ATOM   3091 N N    . TRP A 1 207 ? -14.52264 -15.40339 31.72985  1.000 23.06977 ? 207 TRP A N    1 
ATOM   3092 C CA   . TRP A 1 207 ? -13.09120 -15.19813 31.53094  1.000 26.35700 ? 207 TRP A CA   1 
ATOM   3093 C C    . TRP A 1 207 ? -12.56542 -14.05382 32.39006  1.000 30.82407 ? 207 TRP A C    1 
ATOM   3094 O O    . TRP A 1 207 ? -11.39512 -14.06699 32.78917  1.000 27.73168 ? 207 TRP A O    1 
ATOM   3095 C CB   . TRP A 1 207 ? -12.84074 -14.95995 30.03989  1.000 25.05932 ? 207 TRP A CB   1 
ATOM   3096 C CG   . TRP A 1 207 ? -11.50209 -14.41556 29.64475  1.000 27.09106 ? 207 TRP A CG   1 
ATOM   3097 C CD1  . TRP A 1 207 ? -10.34106 -15.11628 29.47846  1.000 30.08441 ? 207 TRP A CD1  1 
ATOM   3098 C CD2  . TRP A 1 207 ? -11.20102 -13.05577 29.30939  1.000 27.35425 ? 207 TRP A CD2  1 
ATOM   3099 N NE1  . TRP A 1 207 ? -9.33194  -14.27048 29.07775  1.000 32.33543 ? 207 TRP A NE1  1 
ATOM   3100 C CE2  . TRP A 1 207 ? -9.83485  -13.00008 28.96838  1.000 29.86020 ? 207 TRP A CE2  1 
ATOM   3101 C CE3  . TRP A 1 207 ? -11.95323 -11.87805 29.27382  1.000 28.77761 ? 207 TRP A CE3  1 
ATOM   3102 C CZ2  . TRP A 1 207 ? -9.20610  -11.81164 28.59660  1.000 31.39032 ? 207 TRP A CZ2  1 
ATOM   3103 C CZ3  . TRP A 1 207 ? -11.32677 -10.69974 28.90983  1.000 31.50318 ? 207 TRP A CZ3  1 
ATOM   3104 C CH2  . TRP A 1 207 ? -9.96789  -10.67595 28.57394  1.000 30.84768 ? 207 TRP A CH2  1 
ATOM   3105 H H    . TRP A 1 207 ? -15.00898 -15.14221 31.07041  1.000 27.70650 ? 207 TRP A H    1 
ATOM   3106 H HA   . TRP A 1 207 ? -12.59318 -15.98736 31.79550  1.000 31.65118 ? 207 TRP A HA   1 
ATOM   3107 H HB2  . TRP A 1 207 ? -12.94501 -15.80821 29.58112  1.000 30.09396 ? 207 TRP A HB2  1 
ATOM   3108 H HB3  . TRP A 1 207 ? -13.50499 -14.32783 29.72353  1.000 30.09396 ? 207 TRP A HB3  1 
ATOM   3109 H HD1  . TRP A 1 207 ? -10.24645 -16.03118 29.61596  1.000 36.12406 ? 207 TRP A HD1  1 
ATOM   3110 H HE1  . TRP A 1 207 ? -8.51841  -14.50143 28.92145  1.000 38.82529 ? 207 TRP A HE1  1 
ATOM   3111 H HE3  . TRP A 1 207 ? -12.85755 -11.88658 29.49073  1.000 34.55591 ? 207 TRP A HE3  1 
ATOM   3112 H HZ2  . TRP A 1 207 ? -8.30365  -11.79231 28.37276  1.000 37.69116 ? 207 TRP A HZ2  1 
ATOM   3113 H HZ3  . TRP A 1 207 ? -11.81679 -9.90961  28.88785  1.000 37.82659 ? 207 TRP A HZ3  1 
ATOM   3114 H HH2  . TRP A 1 207 ? -9.57420  -9.86952  28.32984  1.000 37.03999 ? 207 TRP A HH2  1 
ATOM   3115 N N    . LEU A 1 208 ? -13.40846 -13.06425 32.69306  1.000 27.38439 ? 208 LEU A N    1 
ATOM   3116 C CA   . LEU A 1 208 ? -13.02561 -12.04810 33.66821  1.000 28.06454 ? 208 LEU A CA   1 
ATOM   3117 C C    . LEU A 1 208 ? -12.94417 -12.63906 35.07189  1.000 28.09881 ? 208 LEU A C    1 
ATOM   3118 O O    . LEU A 1 208 ? -12.06764 -12.26322 35.85924  1.000 29.18767 ? 208 LEU A O    1 
ATOM   3119 C CB   . LEU A 1 208 ? -14.01549 -10.88592 33.62727  1.000 29.74970 ? 208 LEU A CB   1 
ATOM   3120 C CG   . LEU A 1 208 ? -13.94911 -10.00550 32.37805  1.000 25.62734 ? 208 LEU A CG   1 
ATOM   3121 C CD1  . LEU A 1 208 ? -15.13220 -9.03681  32.34104  1.000 25.60497 ? 208 LEU A CD1  1 
ATOM   3122 C CD2  . LEU A 1 208 ? -12.64075 -9.24466  32.32609  1.000 28.50369 ? 208 LEU A CD2  1 
ATOM   3123 H H    . LEU A 1 208 ? -14.19217 -12.96170 32.35411  1.000 32.88404 ? 208 LEU A H    1 
ATOM   3124 H HA   . LEU A 1 208 ? -12.14961 -11.70179 33.43674  1.000 33.70023 ? 208 LEU A HA   1 
ATOM   3125 H HB2  . LEU A 1 208 ? -14.91341 -11.24943 33.67726  1.000 35.72241 ? 208 LEU A HB2  1 
ATOM   3126 H HB3  . LEU A 1 208 ? -13.84570 -10.31480 34.39270  1.000 35.72241 ? 208 LEU A HB3  1 
ATOM   3127 H HG   . LEU A 1 208 ? -13.99684 -10.57328 31.59303  1.000 30.77559 ? 208 LEU A HG   1 
ATOM   3128 H HD11 . LEU A 1 208 ? -15.02400 -8.37910  33.04575  1.000 30.74874 ? 208 LEU A HD11 1 
ATOM   3129 H HD12 . LEU A 1 208 ? -15.15242 -8.59586  31.47730  1.000 30.74874 ? 208 LEU A HD12 1 
ATOM   3130 H HD13 . LEU A 1 208 ? -15.95301 -9.53546  32.47716  1.000 30.74874 ? 208 LEU A HD13 1 
ATOM   3131 H HD21 . LEU A 1 208 ? -12.53717 -8.73815  33.14684  1.000 34.22721 ? 208 LEU A HD21 1 
ATOM   3132 H HD22 . LEU A 1 208 ? -11.91113 -9.87708  32.23337  1.000 34.22721 ? 208 LEU A HD22 1 
ATOM   3133 H HD23 . LEU A 1 208 ? -12.65544 -8.64276  31.56557  1.000 34.22721 ? 208 LEU A HD23 1 
ATOM   3134 N N    . TYR A 1 209 ? -13.84999 -13.56226 35.40525  1.000 28.62667 ? 209 TYR A N    1 
ATOM   3135 C CA   . TYR A 1 209 ? -13.72463 -14.29877 36.65999  1.000 33.52599 ? 209 TYR A CA   1 
ATOM   3136 C C    . TYR A 1 209 ? -12.44018 -15.11676 36.67654  1.000 34.86753 ? 209 TYR A C    1 
ATOM   3137 O O    . TYR A 1 209 ? -11.70556 -15.12510 37.67118  1.000 34.54951 ? 209 TYR A O    1 
ATOM   3138 C CB   . TYR A 1 209 ? -14.93911 -15.20643 36.86793  1.000 29.18916 ? 209 TYR A CB   1 
ATOM   3139 C CG   . TYR A 1 209 ? -16.14178 -14.50644 37.46856  1.000 32.54121 ? 209 TYR A CG   1 
ATOM   3140 C CD1  . TYR A 1 209 ? -16.12521 -14.06135 38.78598  1.000 37.47853 ? 209 TYR A CD1  1 
ATOM   3141 C CD2  . TYR A 1 209 ? -17.29718 -14.30130 36.72438  1.000 31.55240 ? 209 TYR A CD2  1 
ATOM   3142 C CE1  . TYR A 1 209 ? -17.22085 -13.42315 39.33916  1.000 34.21947 ? 209 TYR A CE1  1 
ATOM   3143 C CE2  . TYR A 1 209 ? -18.39766 -13.66458 37.27131  1.000 33.52340 ? 209 TYR A CE2  1 
ATOM   3144 C CZ   . TYR A 1 209 ? -18.35321 -13.22853 38.57636  1.000 33.94488 ? 209 TYR A CZ   1 
ATOM   3145 O OH   . TYR A 1 209 ? -19.44564 -12.59342 39.12014  1.000 35.01129 ? 209 TYR A OH   1 
ATOM   3146 H H    . TYR A 1 209 ? -14.53391 -13.77616 34.92974  1.000 34.37478 ? 209 TYR A H    1 
ATOM   3147 H HA   . TYR A 1 209 ? -13.69806 -13.66441 37.39333  1.000 40.25396 ? 209 TYR A HA   1 
ATOM   3148 H HB2  . TYR A 1 209 ? -15.20750 -15.56724 36.00846  1.000 35.04977 ? 209 TYR A HB2  1 
ATOM   3149 H HB3  . TYR A 1 209 ? -14.68874 -15.92726 37.46678  1.000 35.04977 ? 209 TYR A HB3  1 
ATOM   3150 H HD1  . TYR A 1 209 ? -15.36450 -14.19503 39.30400  1.000 44.99701 ? 209 TYR A HD1  1 
ATOM   3151 H HD2  . TYR A 1 209 ? -17.33162 -14.59704 35.84333  1.000 37.88566 ? 209 TYR A HD2  1 
ATOM   3152 H HE1  . TYR A 1 209 ? -17.19397 -13.12705 40.22036  1.000 41.08614 ? 209 TYR A HE1  1 
ATOM   3153 H HE2  . TYR A 1 209 ? -19.16306 -13.53203 36.75994  1.000 40.25085 ? 209 TYR A HE2  1 
ATOM   3154 H HH   . TYR A 1 209 ? -19.46583 -11.79176 38.87009  1.000 42.03632 ? 209 TYR A HH   1 
ATOM   3155 N N    . ALA A 1 210 ? -12.15771 -15.82016 35.57700  1.000 30.64119 ? 210 ALA A N    1 
ATOM   3156 C CA   . ALA A 1 210 ? -10.90154 -16.55280 35.46952  1.000 31.07103 ? 210 ALA A CA   1 
ATOM   3157 C C    . ALA A 1 210 ? -9.71180  -15.62436 35.67054  1.000 33.64411 ? 210 ALA A C    1 
ATOM   3158 O O    . ALA A 1 210 ? -8.69368  -16.02010 36.25096  1.000 36.95281 ? 210 ALA A O    1 
ATOM   3159 C CB   . ALA A 1 210 ? -10.81712 -17.24602 34.10958  1.000 36.16461 ? 210 ALA A CB   1 
ATOM   3160 H H    . ALA A 1 210 ? -12.67072 -15.88705 34.89001  1.000 36.79220 ? 210 ALA A H    1 
ATOM   3161 H HA   . ALA A 1 210 ? -10.87297 -17.23602 36.15749  1.000 37.30801 ? 210 ALA A HA   1 
ATOM   3162 H HB1  . ALA A 1 210 ? -11.62853 -17.75748 33.96492  1.000 43.42031 ? 210 ALA A HB1  1 
ATOM   3163 H HB2  . ALA A 1 210 ? -10.72246 -16.57308 33.41743  1.000 43.42031 ? 210 ALA A HB2  1 
ATOM   3164 H HB3  . ALA A 1 210 ? -10.04804 -17.83712 34.10363  1.000 43.42031 ? 210 ALA A HB3  1 
ATOM   3165 N N    . ALA A 1 211 ? -9.82509  -14.37950 35.20244  1.000 30.99919 ? 211 ALA A N    1 
ATOM   3166 C CA   . ALA A 1 211 ? -8.73169  -13.42904 35.36406  1.000 33.52546 ? 211 ALA A CA   1 
ATOM   3167 C C    . ALA A 1 211 ? -8.52340  -13.07699 36.83117  1.000 38.90552 ? 211 ALA A C    1 
ATOM   3168 O O    . ALA A 1 211 ? -7.38176  -12.93790 37.28585  1.000 36.77733 ? 211 ALA A O    1 
ATOM   3169 C CB   . ALA A 1 211 ? -9.00990  -12.16758 34.54871  1.000 35.55915 ? 211 ALA A CB   1 
ATOM   3170 H H    . ALA A 1 211 ? -10.51458 -14.06719 34.79420  1.000 37.22180 ? 211 ALA A H    1 
ATOM   3171 H HA   . ALA A 1 211 ? -7.91512  -13.83130 35.02894  1.000 40.25332 ? 211 ALA A HA   1 
ATOM   3172 H HB1  . ALA A 1 211 ? -8.18644  -11.66333 34.45623  1.000 42.69375 ? 211 ALA A HB1  1 
ATOM   3173 H HB2  . ALA A 1 211 ? -9.34095  -12.42376 33.67368  1.000 42.69375 ? 211 ALA A HB2  1 
ATOM   3174 H HB3  . ALA A 1 211 ? -9.67485  -11.63330 35.01054  1.000 42.69375 ? 211 ALA A HB3  1 
ATOM   3175 N N    . VAL A 1 212 ? -9.61462  -12.92574 37.58631  1.000 37.82565 ? 212 VAL A N    1 
ATOM   3176 C CA   . VAL A 1 212 ? -9.49507  -12.60724 39.00615  1.000 39.12136 ? 212 VAL A CA   1 
ATOM   3177 C C    . VAL A 1 212 ? -8.93285  -13.79658 39.77311  1.000 39.04088 ? 212 VAL A C    1 
ATOM   3178 O O    . VAL A 1 212 ? -8.06401  -13.63909 40.63911  1.000 42.97709 ? 212 VAL A O    1 
ATOM   3179 C CB   . VAL A 1 212 ? -10.85616 -12.16254 39.57279  1.000 40.23546 ? 212 VAL A CB   1 
ATOM   3180 C CG1  . VAL A 1 212 ? -10.80692 -12.09929 41.09925  1.000 40.69915 ? 212 VAL A CG1  1 
ATOM   3181 C CG2  . VAL A 1 212 ? -11.25046 -10.81345 38.99872  1.000 35.18318 ? 212 VAL A CG2  1 
ATOM   3182 H H    . VAL A 1 212 ? -10.42322 -13.00153 37.30342  1.000 45.41356 ? 212 VAL A H    1 
ATOM   3183 H HA   . VAL A 1 212 ? -8.87492  -11.86761 39.10238  1.000 46.96841 ? 212 VAL A HA   1 
ATOM   3184 H HB   . VAL A 1 212 ? -11.52975 -12.81255 39.31853  1.000 48.30532 ? 212 VAL A HB   1 
ATOM   3185 H HG11 . VAL A 1 212 ? -11.58456 -11.61667 41.42057  1.000 48.86175 ? 212 VAL A HG11 1 
ATOM   3186 H HG12 . VAL A 1 212 ? -10.80870 -13.00249 41.45296  1.000 48.86175 ? 212 VAL A HG12 1 
ATOM   3187 H HG13 . VAL A 1 212 ? -9.99697  -11.63950 41.37030  1.000 48.86175 ? 212 VAL A HG13 1 
ATOM   3188 H HG21 . VAL A 1 212 ? -12.17729 -10.63406 39.22169  1.000 42.24260 ? 212 VAL A HG21 1 
ATOM   3189 H HG22 . VAL A 1 212 ? -10.67975 -10.12858 39.38100  1.000 42.24260 ? 212 VAL A HG22 1 
ATOM   3190 H HG23 . VAL A 1 212 ? -11.14040 -10.83587 38.03525  1.000 42.24260 ? 212 VAL A HG23 1 
ATOM   3191 N N    . ILE A 1 213 ? -9.41772  -15.00335 39.47327  1.000 41.52354 ? 213 ILE A N    1 
ATOM   3192 C CA   . ILE A 1 213 ? -8.88969  -16.21212 40.08834  1.000 40.04899 ? 213 ILE A CA   1 
ATOM   3193 C C    . ILE A 1 213 ? -7.39768  -16.38409 39.83098  1.000 45.19131 ? 213 ILE A C    1 
ATOM   3194 O O    . ILE A 1 213 ? -6.74951  -17.18536 40.51120  1.000 45.46616 ? 213 ILE A O    1 
ATOM   3195 C CB   . ILE A 1 213 ? -9.68328  -17.44244 39.58666  1.000 40.51396 ? 213 ILE A CB   1 
ATOM   3196 C CG1  . ILE A 1 213 ? -11.09002 -17.44992 40.19574  1.000 40.07754 ? 213 ILE A CG1  1 
ATOM   3197 C CG2  . ILE A 1 213 ? -8.96061  -18.74274 39.93097  1.000 44.40134 ? 213 ILE A CG2  1 
ATOM   3198 C CD1  . ILE A 1 213 ? -12.08286 -18.31011 39.45012  1.000 37.16078 ? 213 ILE A CD1  1 
ATOM   3199 H H    . ILE A 1 213 ? -10.05527 -15.14484 38.91371  1.000 49.85103 ? 213 ILE A H    1 
ATOM   3200 H HA   . ILE A 1 213 ? -9.01022  -16.15307 41.04901  1.000 48.08157 ? 213 ILE A HA   1 
ATOM   3201 H HB   . ILE A 1 213 ? -9.75235  -17.37672 38.62136  1.000 48.63952 ? 213 ILE A HB   1 
ATOM   3202 H HG12 . ILE A 1 213 ? -11.03308 -17.78617 41.10381  1.000 48.11582 ? 213 ILE A HG12 1 
ATOM   3203 H HG13 . ILE A 1 213 ? -11.43147 -16.54201 40.19896  1.000 48.11582 ? 213 ILE A HG13 1 
ATOM   3204 H HG21 . ILE A 1 213 ? -9.57988  -19.48315 39.83507  1.000 53.30438 ? 213 ILE A HG21 1 
ATOM   3205 H HG22 . ILE A 1 213 ? -8.21147  -18.85754 39.32556  1.000 53.30438 ? 213 ILE A HG22 1 
ATOM   3206 H HG23 . ILE A 1 213 ? -8.64209  -18.69430 40.84590  1.000 53.30438 ? 213 ILE A HG23 1 
ATOM   3207 H HD11 . ILE A 1 213 ? -12.89480 -18.38315 39.97578  1.000 44.61572 ? 213 ILE A HD11 1 
ATOM   3208 H HD12 . ILE A 1 213 ? -12.27872 -17.89703 38.59461  1.000 44.61572 ? 213 ILE A HD12 1 
ATOM   3209 H HD13 . ILE A 1 213 ? -11.69778 -19.18967 39.31231  1.000 44.61572 ? 213 ILE A HD13 1 
ATOM   3210 N N    . ASN A 1 214 ? -6.82992  -15.63393 38.87909  1.000 40.96401 ? 214 ASN A N    1 
ATOM   3211 C CA   . ASN A 1 214 ? -5.41819  -15.74632 38.52517  1.000 41.92701 ? 214 ASN A CA   1 
ATOM   3212 C C    . ASN A 1 214 ? -4.66293  -14.42909 38.68935  1.000 42.94923 ? 214 ASN A C    1 
ATOM   3213 O O    . ASN A 1 214 ? -3.56486  -14.27802 38.14322  1.000 47.30753 ? 214 ASN A O    1 
ATOM   3214 C CB   . ASN A 1 214 ? -5.27533  -16.26920 37.09443  1.000 42.63123 ? 214 ASN A CB   1 
ATOM   3215 C CG   . ASN A 1 214 ? -5.71937  -17.71337 36.95977  1.000 38.36778 ? 214 ASN A CG   1 
ATOM   3216 O OD1  . ASN A 1 214 ? -4.92548  -18.63662 37.14188  1.000 44.97454 ? 214 ASN A OD1  1 
ATOM   3217 N ND2  . ASN A 1 214 ? -6.99520  -17.91667 36.65109  1.000 36.37771 ? 214 ASN A ND2  1 
ATOM   3218 H H    . ASN A 1 214 ? -7.25304  -15.04359 38.41859  1.000 49.17959 ? 214 ASN A H    1 
ATOM   3219 H HA   . ASN A 1 214 ? -5.00383  -16.38466 39.12660  1.000 50.33519 ? 214 ASN A HA   1 
ATOM   3220 H HB2  . ASN A 1 214 ? -5.82253  -15.72918 36.50294  1.000 51.18026 ? 214 ASN A HB2  1 
ATOM   3221 H HB3  . ASN A 1 214 ? -4.34437  -16.21394 36.82770  1.000 51.18026 ? 214 ASN A HB3  1 
ATOM   3222 H HD21 . ASN A 1 214 ? -7.29403  -18.71835 36.56384  1.000 43.67603 ? 214 ASN A HD21 1 
ATOM   3223 H HD22 . ASN A 1 214 ? -7.52241  -17.24662 36.53849  1.000 43.67603 ? 214 ASN A HD22 1 
ATOM   3224 N N    . GLY A 1 215 ? -5.22554  -13.46815 39.42139  1.000 43.16638 ? 215 GLY A N    1 
ATOM   3225 C CA   . GLY A 1 215 ? -4.46634  -12.32679 39.88938  1.000 45.73415 ? 215 GLY A CA   1 
ATOM   3226 C C    . GLY A 1 215 ? -4.55530  -11.05998 39.06473  1.000 46.79679 ? 215 GLY A C    1 
ATOM   3227 O O    . GLY A 1 215 ? -3.92652  -10.06122 39.43762  1.000 47.76289 ? 215 GLY A O    1 
ATOM   3228 H H    . GLY A 1 215 ? -6.05227  -13.46101 39.65819  1.000 51.82243 ? 215 GLY A H    1 
ATOM   3229 H HA2  . GLY A 1 215 ? -4.76951  -12.10835 40.78451  1.000 54.90375 ? 215 GLY A HA2  1 
ATOM   3230 H HA3  . GLY A 1 215 ? -3.53076  -12.58028 39.92590  1.000 54.90375 ? 215 GLY A HA3  1 
ATOM   3231 N N    . ASP A 1 216 ? -5.29249  -11.05873 37.95827  1.000 46.58063 ? 216 ASP A N    1 
ATOM   3232 C CA   . ASP A 1 216 ? -5.51349  -9.84112  37.18335  1.000 43.73930 ? 216 ASP A CA   1 
ATOM   3233 C C    . ASP A 1 216 ? -6.76913  -9.16185  37.72266  1.000 43.25768 ? 216 ASP A C    1 
ATOM   3234 O O    . ASP A 1 216 ? -7.88724  -9.63496  37.49325  1.000 43.39964 ? 216 ASP A O    1 
ATOM   3235 C CB   . ASP A 1 216 ? -5.63632  -10.15620 35.69417  1.000 45.67164 ? 216 ASP A CB   1 
ATOM   3236 C CG   . ASP A 1 216 ? -4.28461  -10.34439 35.02036  1.000 50.16676 ? 216 ASP A CG   1 
ATOM   3237 O OD1  . ASP A 1 216 ? -3.27991  -9.79620  35.52232  1.000 50.97687 ? 216 ASP A OD1  1 
ATOM   3238 O OD2  . ASP A 1 216 ? -4.22897  -11.03662 33.98176  1.000 45.68054 ? 216 ASP A OD2  1 
ATOM   3239 H H    . ASP A 1 216 ? -5.67806  -11.75548 37.63351  1.000 55.91953 ? 216 ASP A H    1 
ATOM   3240 H HA   . ASP A 1 216 ? -4.76151  -9.23833  37.29321  1.000 52.50994 ? 216 ASP A HA   1 
ATOM   3241 H HB2  . ASP A 1 216 ? -6.14291  -10.97618 35.58505  1.000 54.82875 ? 216 ASP A HB2  1 
ATOM   3242 H HB3  . ASP A 1 216 ? -6.09255  -9.42307  35.25229  1.000 54.82875 ? 216 ASP A HB3  1 
ATOM   3243 N N    . ARG A 1 217 ? -6.58113  -8.05281  38.44368  1.000 44.09076 ? 217 ARG A N    1 
ATOM   3244 C CA   . ARG A 1 217 ? -7.65891  -7.38624  39.16265  1.000 45.30739 ? 217 ARG A CA   1 
ATOM   3245 C C    . ARG A 1 217 ? -7.86671  -5.93361  38.75842  1.000 43.11710 ? 217 ARG A C    1 
ATOM   3246 O O    . ARG A 1 217 ? -8.79181  -5.29355  39.27414  1.000 39.75899 ? 217 ARG A O    1 
ATOM   3247 C CB   . ARG A 1 217 ? -7.39248  -7.42564  40.67507  1.000 49.63125 ? 217 ARG A CB   1 
ATOM   3248 C CG   . ARG A 1 217 ? -7.55234  -8.78613  41.32408  1.000 51.89332 ? 217 ARG A CG   1 
ATOM   3249 C CD   . ARG A 1 217 ? -7.66777  -8.66623  42.84599  1.000 61.39475 ? 217 ARG A CD   1 
ATOM   3250 N NE   . ARG A 1 217 ? -6.76506  -7.66035  43.40041  1.000 71.87950 ? 217 ARG A NE   1 
ATOM   3251 C CZ   . ARG A 1 217 ? -7.13516  -6.46771  43.85457  1.000 77.37631 ? 217 ARG A CZ   1 
ATOM   3252 N NH1  . ARG A 1 217 ? -8.40309  -6.08548  43.85796  1.000 66.26318 ? 217 ARG A NH1  1 
ATOM   3253 N NH2  . ARG A 1 217 ? -6.20773  -5.63664  44.32258  1.000 69.39839 ? 217 ARG A NH2  1 
ATOM   3254 H H    . ARG A 1 217 ? -5.81992  -7.66223  38.53091  1.000 52.93169 ? 217 ARG A H    1 
ATOM   3255 H HA   . ARG A 1 217 ? -8.47772  -7.87019  38.97228  1.000 54.39164 ? 217 ARG A HA   1 
ATOM   3256 H HB2  . ARG A 1 217 ? -6.48076  -7.13454  40.83292  1.000 59.58027 ? 217 ARG A HB2  1 
ATOM   3257 H HB3  . ARG A 1 217 ? -8.01378  -6.82170  41.11112  1.000 59.58027 ? 217 ARG A HB3  1 
ATOM   3258 H HG2  . ARG A 1 217 ? -8.35776  -9.21022  40.98890  1.000 62.29476 ? 217 ARG A HG2  1 
ATOM   3259 H HG3  . ARG A 1 217 ? -6.77873  -9.33397  41.11841  1.000 62.29476 ? 217 ARG A HG3  1 
ATOM   3260 H HD2  . ARG A 1 217 ? -8.57580  -8.41427  43.07596  1.000 73.69648 ? 217 ARG A HD2  1 
ATOM   3261 H HD3  . ARG A 1 217 ? -7.44858  -9.52105  43.24865  1.000 73.69648 ? 217 ARG A HD3  1 
ATOM   3262 H HE   . ARG A 1 217 ? -5.92822  -7.85544  43.43563  1.000 86.27818 ? 217 ARG A HE   1 
ATOM   3263 H HH11 . ARG A 1 217 ? -9.01249  -6.61456  43.56079  1.000 79.53860 ? 217 ARG A HH11 1 
ATOM   3264 H HH12 . ARG A 1 217 ? -8.61708  -5.30819  44.15732  1.000 79.53860 ? 217 ARG A HH12 1 
ATOM   3265 H HH21 . ARG A 1 217 ? -5.38116  -5.87401  44.32844  1.000 83.30085 ? 217 ARG A HH21 1 
ATOM   3266 H HH22 . ARG A 1 217 ? -6.43477  -4.86202  44.61927  1.000 83.30085 ? 217 ARG A HH22 1 
ATOM   3267 N N    . TRP A 1 218 ? -7.04506  -5.39178  37.85654  1.000 38.16237 ? 218 TRP A N    1 
ATOM   3268 C CA   . TRP A 1 218 ? -7.03427  -3.94805  37.64295  1.000 37.93304 ? 218 TRP A CA   1 
ATOM   3269 C C    . TRP A 1 218 ? -8.36705  -3.41437  37.13490  1.000 39.11898 ? 218 TRP A C    1 
ATOM   3270 O O    . TRP A 1 218 ? -8.62131  -2.21028  37.25136  1.000 37.37659 ? 218 TRP A O    1 
ATOM   3271 C CB   . TRP A 1 218 ? -5.92320  -3.56140  36.66110  1.000 40.99325 ? 218 TRP A CB   1 
ATOM   3272 C CG   . TRP A 1 218 ? -6.05983  -4.16207  35.28745  1.000 36.99517 ? 218 TRP A CG   1 
ATOM   3273 C CD1  . TRP A 1 218 ? -5.49162  -5.32002  34.84011  1.000 39.57076 ? 218 TRP A CD1  1 
ATOM   3274 C CD2  . TRP A 1 218 ? -6.79928  -3.62623  34.18071  1.000 39.01863 ? 218 TRP A CD2  1 
ATOM   3275 N NE1  . TRP A 1 218 ? -5.83369  -5.54072  33.52698  1.000 35.16715 ? 218 TRP A NE1  1 
ATOM   3276 C CE2  . TRP A 1 218 ? -6.63577  -4.51604  33.09862  1.000 38.31141 ? 218 TRP A CE2  1 
ATOM   3277 C CE3  . TRP A 1 218 ? -7.58427  -2.48316  34.00009  1.000 37.31458 ? 218 TRP A CE3  1 
ATOM   3278 C CZ2  . TRP A 1 218 ? -7.22945  -4.29841  31.85591  1.000 39.90346 ? 218 TRP A CZ2  1 
ATOM   3279 C CZ3  . TRP A 1 218 ? -8.17317  -2.26961  32.76473  1.000 42.25937 ? 218 TRP A CZ3  1 
ATOM   3280 C CH2  . TRP A 1 218 ? -7.99205  -3.17252  31.70965  1.000 41.15597 ? 218 TRP A CH2  1 
ATOM   3281 H H    . TRP A 1 218 ? -6.49403  -5.83218  37.36458  1.000 45.81762 ? 218 TRP A H    1 
ATOM   3282 H HA   . TRP A 1 218 ? -6.84936  -3.52425  38.49565  1.000 45.54242 ? 218 TRP A HA   1 
ATOM   3283 H HB2  . TRP A 1 218 ? -5.92385  -2.59676  36.55923  1.000 49.21468 ? 218 TRP A HB2  1 
ATOM   3284 H HB3  . TRP A 1 218 ? -5.07379  -3.85597  37.02530  1.000 49.21468 ? 218 TRP A HB3  1 
ATOM   3285 H HD1  . TRP A 1 218 ? -4.95101  -5.87901  35.35019  1.000 47.50769 ? 218 TRP A HD1  1 
ATOM   3286 H HE1  . TRP A 1 218 ? -5.58464  -6.21279  33.05170  1.000 42.22335 ? 218 TRP A HE1  1 
ATOM   3287 H HE3  . TRP A 1 218 ? -7.70846  -1.87837  34.69558  1.000 44.80028 ? 218 TRP A HE3  1 
ATOM   3288 H HZ2  . TRP A 1 218 ? -7.11137  -4.89608  31.15324  1.000 47.90693 ? 218 TRP A HZ2  1 
ATOM   3289 H HZ3  . TRP A 1 218 ? -8.69814  -1.51323  32.63361  1.000 50.73402 ? 218 TRP A HZ3  1 
ATOM   3290 H HH2  . TRP A 1 218 ? -8.39952  -3.00271  30.89109  1.000 49.40994 ? 218 TRP A HH2  1 
ATOM   3291 N N    . PHE A 1 219 ? -9.22081  -4.27241  36.57943  1.000 35.77431 ? 219 PHE A N    1 
ATOM   3292 C CA   . PHE A 1 219 ? -10.47005 -3.83465  35.96879  1.000 38.56943 ? 219 PHE A CA   1 
ATOM   3293 C C    . PHE A 1 219 ? -11.64430 -3.83290  36.94026  1.000 37.07445 ? 219 PHE A C    1 
ATOM   3294 O O    . PHE A 1 219 ? -12.72269 -3.34783  36.58088  1.000 37.82340 ? 219 PHE A O    1 
ATOM   3295 C CB   . PHE A 1 219 ? -10.80694 -4.72292  34.76317  1.000 38.06951 ? 219 PHE A CB   1 
ATOM   3296 C CG   . PHE A 1 219 ? -10.73364 -6.18888  35.06029  1.000 35.76954 ? 219 PHE A CG   1 
ATOM   3297 C CD1  . PHE A 1 219 ? -11.81695 -6.85576  35.60393  1.000 33.01985 ? 219 PHE A CD1  1 
ATOM   3298 C CD2  . PHE A 1 219 ? -9.57069  -6.89697  34.81348  1.000 36.23322 ? 219 PHE A CD2  1 
ATOM   3299 C CE1  . PHE A 1 219 ? -11.74359 -8.20432  35.88803  1.000 33.88763 ? 219 PHE A CE1  1 
ATOM   3300 C CE2  . PHE A 1 219 ? -9.49119  -8.24267  35.09530  1.000 36.43308 ? 219 PHE A CE2  1 
ATOM   3301 C CZ   . PHE A 1 219 ? -10.57822 -8.89872  35.63284  1.000 35.51967 ? 219 PHE A CZ   1 
ATOM   3302 H H    . PHE A 1 219 ? -9.09603  -5.12258  36.54414  1.000 42.95195 ? 219 PHE A H    1 
ATOM   3303 H HA   . PHE A 1 219 ? -10.35461 -2.92683  35.64717  1.000 46.30609 ? 219 PHE A HA   1 
ATOM   3304 H HB2  . PHE A 1 219 ? -11.71029 -4.52405  34.47110  1.000 45.70619 ? 219 PHE A HB2  1 
ATOM   3305 H HB3  . PHE A 1 219 ? -10.17812 -4.53289  34.04947  1.000 45.70619 ? 219 PHE A HB3  1 
ATOM   3306 H HD1  . PHE A 1 219 ? -12.60278 -6.39052  35.77976  1.000 39.64659 ? 219 PHE A HD1  1 
ATOM   3307 H HD2  . PHE A 1 219 ? -8.83384  -6.45882  34.45293  1.000 43.50264 ? 219 PHE A HD2  1 
ATOM   3308 H HE1  . PHE A 1 219 ? -12.47812 -8.64450  36.25081  1.000 40.68793 ? 219 PHE A HE1  1 
ATOM   3309 H HE2  . PHE A 1 219 ? -8.70490  -8.70852  34.92316  1.000 43.74247 ? 219 PHE A HE2  1 
ATOM   3310 H HZ   . PHE A 1 219 ? -10.52637 -9.80756  35.82317  1.000 42.64638 ? 219 PHE A HZ   1 
ATOM   3311 N N    . LEU A 1 220 ? -11.47260 -4.36808  38.14550  1.000 36.15302 ? 220 LEU A N    1 
ATOM   3312 C CA   . LEU A 1 220 ? -12.50764 -4.25254  39.16221  1.000 39.93764 ? 220 LEU A CA   1 
ATOM   3313 C C    . LEU A 1 220 ? -12.62846 -2.80161  39.61513  1.000 37.91301 ? 220 LEU A C    1 
ATOM   3314 O O    . LEU A 1 220 ? -11.63981 -2.06471  39.68219  1.000 38.05105 ? 220 LEU A O    1 
ATOM   3315 C CB   . LEU A 1 220 ? -12.19542 -5.16086  40.35110  1.000 43.54999 ? 220 LEU A CB   1 
ATOM   3316 C CG   . LEU A 1 220 ? -12.06645 -6.65201  40.02266  1.000 42.43262 ? 220 LEU A CG   1 
ATOM   3317 C CD1  . LEU A 1 220 ? -11.88649 -7.47589  41.29398  1.000 47.20832 ? 220 LEU A CD1  1 
ATOM   3318 C CD2  . LEU A 1 220 ? -13.26991 -7.14756  39.22922  1.000 41.13602 ? 220 LEU A CD2  1 
ATOM   3319 H H    . LEU A 1 220 ? -10.77178 -4.79897  38.39609  1.000 43.40640 ? 220 LEU A H    1 
ATOM   3320 H HA   . LEU A 1 220 ? -13.36105 -4.53376  38.79682  1.000 47.94794 ? 220 LEU A HA   1 
ATOM   3321 H HB2  . LEU A 1 220 ? -11.35357 -4.87581  40.73961  1.000 52.28277 ? 220 LEU A HB2  1 
ATOM   3322 H HB3  . LEU A 1 220 ? -12.90920 -5.06800  41.00132  1.000 52.28277 ? 220 LEU A HB3  1 
ATOM   3323 H HG   . LEU A 1 220 ? -11.27805 -6.77486  39.47109  1.000 50.94192 ? 220 LEU A HG   1 
ATOM   3324 H HD11 . LEU A 1 220 ? -11.00925 -7.29473  41.66617  1.000 56.67276 ? 220 LEU A HD11 1 
ATOM   3325 H HD12 . LEU A 1 220 ? -12.57405 -7.22721  41.93142  1.000 56.67276 ? 220 LEU A HD12 1 
ATOM   3326 H HD13 . LEU A 1 220 ? -11.96443 -8.41736  41.07385  1.000 56.67276 ? 220 LEU A HD13 1 
ATOM   3327 H HD21 . LEU A 1 220 ? -14.08199 -6.85034  39.66863  1.000 49.38600 ? 220 LEU A HD21 1 
ATOM   3328 H HD22 . LEU A 1 220 ? -13.22759 -6.78365  38.33107  1.000 49.38600 ? 220 LEU A HD22 1 
ATOM   3329 H HD23 . LEU A 1 220 ? -13.24814 -8.11671  39.19480  1.000 49.38600 ? 220 LEU A HD23 1 
ATOM   3330 N N    . ASN A 1 221 ? -13.85574 -2.38593  39.91382  1.000 39.16386 ? 221 ASN A N    1 
ATOM   3331 C CA   . ASN A 1 221 ? -14.13439 -0.98816  40.21374  1.000 36.18242 ? 221 ASN A CA   1 
ATOM   3332 C C    . ASN A 1 221 ? -15.19422 -0.91890  41.30891  1.000 37.14088 ? 221 ASN A C    1 
ATOM   3333 O O    . ASN A 1 221 ? -15.58446 -1.93428  41.89374  1.000 37.26394 ? 221 ASN A O    1 
ATOM   3334 C CB   . ASN A 1 221 ? -14.55799 -0.24358  38.93926  1.000 35.32022 ? 221 ASN A CB   1 
ATOM   3335 C CG   . ASN A 1 221 ? -15.81359 -0.81850  38.31241  1.000 35.25361 ? 221 ASN A CG   1 
ATOM   3336 O OD1  . ASN A 1 221 ? -16.64490 -1.42119  38.99006  1.000 34.43326 ? 221 ASN A OD1  1 
ATOM   3337 N ND2  . ASN A 1 221 ? -15.95730 -0.63034  37.00649  1.000 37.63846 ? 221 ASN A ND2  1 
ATOM   3338 H H    . ASN A 1 221 ? -14.54573 -2.89807  39.94894  1.000 47.01941 ? 221 ASN A H    1 
ATOM   3339 H HA   . ASN A 1 221 ? -13.32491 -0.58123  40.56024  1.000 43.44168 ? 221 ASN A HA   1 
ATOM   3340 H HB2  . ASN A 1 221 ? -14.73087 0.68531   39.15876  1.000 42.40704 ? 221 ASN A HB2  1 
ATOM   3341 H HB3  . ASN A 1 221 ? -13.84298 -0.30269  38.28644  1.000 42.40704 ? 221 ASN A HB3  1 
ATOM   3342 H HD21 . ASN A 1 221 ? -16.65169 -0.93636  36.60180  1.000 45.18893 ? 221 ASN A HD21 1 
ATOM   3343 H HD22 . ASN A 1 221 ? -15.35603 -0.20240  36.56497  1.000 45.18893 ? 221 ASN A HD22 1 
ATOM   3344 N N    . ARG A 1 222 ? -15.66407 0.29983   41.57984  1.000 37.59383 ? 222 ARG A N    1 
ATOM   3345 C CA   . ARG A 1 222 ? -16.61092 0.57247   42.65159  1.000 38.08932 ? 222 ARG A CA   1 
ATOM   3346 C C    . ARG A 1 222 ? -18.04439 0.69388   42.14873  1.000 38.82763 ? 222 ARG A C    1 
ATOM   3347 O O    . ARG A 1 222 ? -18.89110 1.26759   42.84295  1.000 36.04707 ? 222 ARG A O    1 
ATOM   3348 C CB   . ARG A 1 222 ? -16.21744 1.85773   43.37999  1.000 40.79818 ? 222 ARG A CB   1 
ATOM   3349 C CG   . ARG A 1 222 ? -14.77158 1.91827   43.83829  1.000 41.97331 ? 222 ARG A CG   1 
ATOM   3350 C CD   . ARG A 1 222 ? -14.39389 3.33793   44.22448  1.000 52.99941 ? 222 ARG A CD   1 
ATOM   3351 N NE   . ARG A 1 222 ? -13.23563 3.38273   45.10724  1.000 54.79438 ? 222 ARG A NE   1 
ATOM   3352 C CZ   . ARG A 1 222 ? -13.28348 3.16296   46.41379  1.000 51.17180 ? 222 ARG A CZ   1 
ATOM   3353 N NH1  . ARG A 1 222 ? -14.41565 2.84410   47.02061  1.000 47.29065 ? 222 ARG A NH1  1 
ATOM   3354 N NH2  . ARG A 1 222 ? -12.16722 3.26376   47.12924  1.000 54.28060 ? 222 ARG A NH2  1 
ATOM   3355 H H    . ARG A 1 222 ? -15.43953 1.00420   41.14049  1.000 45.13537 ? 222 ARG A H    1 
ATOM   3356 H HA   . ARG A 1 222 ? -16.57494 -0.16528  43.28033  1.000 45.72997 ? 222 ARG A HA   1 
ATOM   3357 H HB2  . ARG A 1 222 ? -16.36454 2.60697   42.78175  1.000 48.98059 ? 222 ARG A HB2  1 
ATOM   3358 H HB3  . ARG A 1 222 ? -16.77625 1.94751   44.16776  1.000 48.98059 ? 222 ARG A HB3  1 
ATOM   3359 H HG2  . ARG A 1 222 ? -14.65164 1.34544   44.61184  1.000 50.39075 ? 222 ARG A HG2  1 
ATOM   3360 H HG3  . ARG A 1 222 ? -14.18997 1.62902   43.11789  1.000 50.39075 ? 222 ARG A HG3  1 
ATOM   3361 H HD2  . ARG A 1 222 ? -14.18090 3.83958   43.42206  1.000 63.62207 ? 222 ARG A HD2  1 
ATOM   3362 H HD3  . ARG A 1 222 ? -15.14053 3.75114   44.68567  1.000 63.62207 ? 222 ARG A HD3  1 
ATOM   3363 H HE   . ARG A 1 222 ? -12.47087 3.56356   44.75790  1.000 65.77603 ? 222 ARG A HE   1 
ATOM   3364 H HH11 . ARG A 1 222 ? -14.42444 2.70569   47.86935  1.000 56.77156 ? 222 ARG A HH11 1 
ATOM   3365 H HH12 . ARG A 1 222 ? -15.14253 2.77532   46.56617  1.000 56.77156 ? 222 ARG A HH12 1 
ATOM   3366 H HH21 . ARG A 1 222 ? -11.42646 3.46927   46.74371  1.000 65.15950 ? 222 ARG A HH21 1 
ATOM   3367 H HH22 . ARG A 1 222 ? -12.18603 3.12345   47.97751  1.000 65.15950 ? 222 ARG A HH22 1 
ATOM   3368 N N    . PHE A 1 223 ? -18.33270 0.17394   40.96155  1.000 35.28505 ? 223 PHE A N    1 
ATOM   3369 C CA   . PHE A 1 223 ? -19.61932 0.36492   40.31413  1.000 34.19541 ? 223 PHE A CA   1 
ATOM   3370 C C    . PHE A 1 223 ? -20.40715 -0.93756  40.29601  1.000 36.23522 ? 223 PHE A C    1 
ATOM   3371 O O    . PHE A 1 223 ? -19.86071 -2.02880  40.48103  1.000 30.49523 ? 223 PHE A O    1 
ATOM   3372 C CB   . PHE A 1 223 ? -19.44015 0.87334   38.87787  1.000 34.55709 ? 223 PHE A CB   1 
ATOM   3373 C CG   . PHE A 1 223 ? -18.54147 2.07362   38.75979  1.000 38.04727 ? 223 PHE A CG   1 
ATOM   3374 C CD1  . PHE A 1 223 ? -18.36108 2.93856   39.82730  1.000 38.98120 ? 223 PHE A CD1  1 
ATOM   3375 C CD2  . PHE A 1 223 ? -17.87515 2.33426   37.57392  1.000 42.61220 ? 223 PHE A CD2  1 
ATOM   3376 C CE1  . PHE A 1 223 ? -17.53315 4.03850   39.71445  1.000 39.23747 ? 223 PHE A CE1  1 
ATOM   3377 C CE2  . PHE A 1 223 ? -17.04654 3.43378   37.45389  1.000 48.46475 ? 223 PHE A CE2  1 
ATOM   3378 C CZ   . PHE A 1 223 ? -16.87532 4.28709   38.52537  1.000 49.07951 ? 223 PHE A CZ   1 
ATOM   3379 H H    . PHE A 1 223 ? -17.78452 -0.30415  40.50270  1.000 42.36484 ? 223 PHE A H    1 
ATOM   3380 H HA   . PHE A 1 223 ? -20.12846 1.02182   40.81430  1.000 41.05727 ? 223 PHE A HA   1 
ATOM   3381 H HB2  . PHE A 1 223 ? -19.05430 0.16243   38.34250  1.000 41.49128 ? 223 PHE A HB2  1 
ATOM   3382 H HB3  . PHE A 1 223 ? -20.30933 1.12005   38.52492  1.000 41.49128 ? 223 PHE A HB3  1 
ATOM   3383 H HD1  . PHE A 1 223 ? -18.80282 2.77652   40.62949  1.000 46.80022 ? 223 PHE A HD1  1 
ATOM   3384 H HD2  . PHE A 1 223 ? -17.98673 1.76216   36.84926  1.000 51.15742 ? 223 PHE A HD2  1 
ATOM   3385 H HE1  . PHE A 1 223 ? -17.41870 4.61114   40.43825  1.000 47.10774 ? 223 PHE A HE1  1 
ATOM   3386 H HE2  . PHE A 1 223 ? -16.60485 3.59859   36.65224  1.000 58.18047 ? 223 PHE A HE2  1 
ATOM   3387 H HZ   . PHE A 1 223 ? -16.31833 5.02771   38.44693  1.000 58.91819 ? 223 PHE A HZ   1 
ATOM   3388 N N    . THR A 1 224 ? -21.71282 -0.80223  40.07402  1.000 35.22909 ? 224 THR A N    1 
ATOM   3389 C CA   . THR A 1 224 ? -22.59093 -1.93447  39.82287  1.000 32.18024 ? 224 THR A CA   1 
ATOM   3390 C C    . THR A 1 224 ? -23.57942 -1.52061  38.74017  1.000 34.23776 ? 224 THR A C    1 
ATOM   3391 O O    . THR A 1 224 ? -23.59326 -0.36953  38.29129  1.000 29.84328 ? 224 THR A O    1 
ATOM   3392 C CB   . THR A 1 224 ? -23.30995 -2.39748  41.09763  1.000 36.09058 ? 224 THR A CB   1 
ATOM   3393 O OG1  . THR A 1 224 ? -23.86328 -3.70287  40.88277  1.000 37.06585 ? 224 THR A OG1  1 
ATOM   3394 C CG2  . THR A 1 224 ? -24.43050 -1.43110  41.48126  1.000 32.67027 ? 224 THR A CG2  1 
ATOM   3395 H H    . THR A 1 224 ? -22.12022 -0.04492  40.06431  1.000 42.29769 ? 224 THR A H    1 
ATOM   3396 H HA   . THR A 1 224 ? -22.06456 -2.68377  39.50289  1.000 38.63907 ? 224 THR A HA   1 
ATOM   3397 H HB   . THR A 1 224 ? -22.67509 -2.42425  41.83052  1.000 43.33147 ? 224 THR A HB   1 
ATOM   3398 H HG1  . THR A 1 224 ? -23.28502 -4.20736  40.54115  1.000 44.50180 ? 224 THR A HG1  1 
ATOM   3399 H HG21 . THR A 1 224 ? -25.15778 -1.49614  40.84271  1.000 39.22710 ? 224 THR A HG21 1 
ATOM   3400 H HG22 . THR A 1 224 ? -24.76711 -1.64742  42.36489  1.000 39.22710 ? 224 THR A HG22 1 
ATOM   3401 H HG23 . THR A 1 224 ? -24.09619 -0.52054  41.48595  1.000 39.22710 ? 224 THR A HG23 1 
ATOM   3402 N N    . THR A 1 225 ? -24.41411 -2.46478  38.31516  1.000 33.35371 ? 225 THR A N    1 
ATOM   3403 C CA   . THR A 1 225 ? -25.33332 -2.22174  37.21371  1.000 37.44999 ? 225 THR A CA   1 
ATOM   3404 C C    . THR A 1 225 ? -26.53360 -3.14911  37.35647  1.000 35.86316 ? 225 THR A C    1 
ATOM   3405 O O    . THR A 1 225 ? -26.58509 -4.00291  38.24590  1.000 34.54487 ? 225 THR A O    1 
ATOM   3406 C CB   . THR A 1 225 ? -24.62986 -2.42192  35.86533  1.000 35.79790 ? 225 THR A CB   1 
ATOM   3407 O OG1  . THR A 1 225 ? -25.45738 -1.92523  34.80698  1.000 37.09849 ? 225 THR A OG1  1 
ATOM   3408 C CG2  . THR A 1 225 ? -24.34239 -3.89789  35.62311  1.000 35.25781 ? 225 THR A CG2  1 
ATOM   3409 H H    . THR A 1 225 ? -24.46565 -3.25509  38.65036  1.000 40.04723 ? 225 THR A H    1 
ATOM   3410 H HA   . THR A 1 225 ? -25.66089 -1.30974  37.25686  1.000 44.96276 ? 225 THR A HA   1 
ATOM   3411 H HB   . THR A 1 225 ? -23.78778 -1.94050  35.87100  1.000 42.98026 ? 225 THR A HB   1 
ATOM   3412 H HG1  . THR A 1 225 ? -25.48907 -1.08635  34.83663  1.000 44.54097 ? 225 THR A HG1  1 
ATOM   3413 H HG21 . THR A 1 225 ? -25.16531 -4.36580  35.41154  1.000 42.33214 ? 225 THR A HG21 1 
ATOM   3414 H HG22 . THR A 1 225 ? -23.72389 -3.99826  34.88265  1.000 42.33214 ? 225 THR A HG22 1 
ATOM   3415 H HG23 . THR A 1 225 ? -23.95011 -4.29410  36.41686  1.000 42.33214 ? 225 THR A HG23 1 
ATOM   3416 N N    . THR A 1 226 ? -27.50881 -2.96320  36.47221  1.000 40.20947 ? 226 THR A N    1 
ATOM   3417 C CA   . THR A 1 226 ? -28.67362 -3.82822  36.37975  1.000 39.56986 ? 226 THR A CA   1 
ATOM   3418 C C    . THR A 1 226 ? -28.61487 -4.63855  35.09179  1.000 38.01748 ? 226 THR A C    1 
ATOM   3419 O O    . THR A 1 226 ? -27.95905 -4.25707  34.11846  1.000 37.69931 ? 226 THR A O    1 
ATOM   3420 C CB   . THR A 1 226 ? -29.97465 -3.01772  36.41369  1.000 35.17117 ? 226 THR A CB   1 
ATOM   3421 O OG1  . THR A 1 226 ? -30.01302 -2.12446  35.29289  1.000 36.47345 ? 226 THR A OG1  1 
ATOM   3422 C CG2  . THR A 1 226 ? -30.08109 -2.22037  37.70828  1.000 37.80539 ? 226 THR A CG2  1 
ATOM   3423 H H    . THR A 1 226 ? -27.51560 -2.32219  35.89892  1.000 48.27415 ? 226 THR A H    1 
ATOM   3424 H HA   . THR A 1 226 ? -28.67773 -4.43708  37.13485  1.000 47.50661 ? 226 THR A HA   1 
ATOM   3425 H HB   . THR A 1 226 ? -30.73257 -3.62149  36.37002  1.000 42.22819 ? 226 THR A HB   1 
ATOM   3426 H HG1  . THR A 1 226 ? -30.65651 -1.59051  35.37296  1.000 43.79092 ? 226 THR A HG1  1 
ATOM   3427 H HG21 . THR A 1 226 ? -29.93035 -2.80221  38.46962  1.000 45.38924 ? 226 THR A HG21 1 
ATOM   3428 H HG22 . THR A 1 226 ? -29.41830 -1.51218  37.71719  1.000 45.38924 ? 226 THR A HG22 1 
ATOM   3429 H HG23 . THR A 1 226 ? -30.96414 -1.82605  37.78340  1.000 45.38924 ? 226 THR A HG23 1 
ATOM   3430 N N    . LEU A 1 227 ? -29.31568 -5.77377  35.10114  1.000 38.08174 ? 227 LEU A N    1 
ATOM   3431 C CA   . LEU A 1 227 ? -29.43939 -6.57863  33.89021  1.000 37.41372 ? 227 LEU A CA   1 
ATOM   3432 C C    . LEU A 1 227 ? -29.91851 -5.72348  32.72386  1.000 40.51474 ? 227 LEU A C    1 
ATOM   3433 O O    . LEU A 1 227 ? -29.37449 -5.79805  31.61537  1.000 41.52662 ? 227 LEU A O    1 
ATOM   3434 C CB   . LEU A 1 227 ? -30.40242 -7.74294  34.14247  1.000 41.92334 ? 227 LEU A CB   1 
ATOM   3435 C CG   . LEU A 1 227 ? -30.01941 -9.15143  33.67949  1.000 40.17409 ? 227 LEU A CG   1 
ATOM   3436 C CD1  . LEU A 1 227 ? -28.58378 -9.50370  34.02515  1.000 39.61220 ? 227 LEU A CD1  1 
ATOM   3437 C CD2  . LEU A 1 227 ? -30.97591 -10.15948 34.31377  1.000 40.74941 ? 227 LEU A CD2  1 
ATOM   3438 H H    . LEU A 1 227 ? -29.72324 -6.09478  35.78702  1.000 45.72087 ? 227 LEU A H    1 
ATOM   3439 H HA   . LEU A 1 227 ? -28.57503 -6.95182  33.65674  1.000 44.91924 ? 227 LEU A HA   1 
ATOM   3440 H HB2  . LEU A 1 227 ? -30.54155 -7.79999  35.10074  1.000 50.33078 ? 227 LEU A HB2  1 
ATOM   3441 H HB3  . LEU A 1 227 ? -31.23752 -7.52821  33.69818  1.000 50.33078 ? 227 LEU A HB3  1 
ATOM   3442 H HG   . LEU A 1 227 ? -30.08756 -9.18936  32.71263  1.000 48.23169 ? 227 LEU A HG   1 
ATOM   3443 H HD11 . LEU A 1 227 ? -27.98923 -9.04154  33.41375  1.000 47.55742 ? 227 LEU A HD11 1 
ATOM   3444 H HD12 . LEU A 1 227 ? -28.40136 -9.22673  34.93669  1.000 47.55742 ? 227 LEU A HD12 1 
ATOM   3445 H HD13 . LEU A 1 227 ? -28.46482 -10.46266 33.94073  1.000 47.55742 ? 227 LEU A HD13 1 
ATOM   3446 H HD21 . LEU A 1 227 ? -30.97182 -10.03651 35.27593  1.000 48.92207 ? 227 LEU A HD21 1 
ATOM   3447 H HD22 . LEU A 1 227 ? -31.86868 -10.01035 33.96503  1.000 48.92207 ? 227 LEU A HD22 1 
ATOM   3448 H HD23 . LEU A 1 227 ? -30.68046 -11.05681 34.09373  1.000 48.92207 ? 227 LEU A HD23 1 
ATOM   3449 N N    . ASN A 1 228 ? -30.92962 -4.88546  32.96370  1.000 41.65803 ? 228 ASN A N    1 
ATOM   3450 C CA   . ASN A 1 228 ? -31.46125 -4.04566  31.89534  1.000 42.99988 ? 228 ASN A CA   1 
ATOM   3451 C C    . ASN A 1 228 ? -30.46659 -2.96286  31.49430  1.000 42.14526 ? 228 ASN A C    1 
ATOM   3452 O O    . ASN A 1 228 ? -30.29970 -2.67642  30.30262  1.000 42.52757 ? 228 ASN A O    1 
ATOM   3453 C CB   . ASN A 1 228 ? -32.78578 -3.41963  32.33204  1.000 45.10920 ? 228 ASN A CB   1 
ATOM   3454 H H    . ASN A 1 228 ? -31.31820 -4.78684  33.72453  1.000 50.01242 ? 228 ASN A H    1 
ATOM   3455 H HA   . ASN A 1 228 ? -31.63067 -4.60070  31.11808  1.000 51.62264 ? 228 ASN A HA   1 
ATOM   3456 N N    . ASP A 1 229 ? -29.79702 -2.34806  32.47238  1.000 39.36528 ? 229 ASP A N    1 
ATOM   3457 C CA   . ASP A 1 229 ? -28.84595 -1.28698  32.15567  1.000 41.79526 ? 229 ASP A CA   1 
ATOM   3458 C C    . ASP A 1 229 ? -27.64504 -1.83482  31.39497  1.000 43.69672 ? 229 ASP A C    1 
ATOM   3459 O O    . ASP A 1 229 ? -27.16405 -1.20624  30.44430  1.000 41.31055 ? 229 ASP A O    1 
ATOM   3460 C CB   . ASP A 1 229 ? -28.39652 -0.58428  33.43846  1.000 41.41030 ? 229 ASP A CB   1 
ATOM   3461 C CG   . ASP A 1 229 ? -27.36787 0.50361   33.18139  1.000 50.48968 ? 229 ASP A CG   1 
ATOM   3462 O OD1  . ASP A 1 229 ? -27.69513 1.47971   32.47434  1.000 46.24061 ? 229 ASP A OD1  1 
ATOM   3463 O OD2  . ASP A 1 229 ? -26.23300 0.38472   33.69110  1.000 45.91048 ? 229 ASP A OD2  1 
ATOM   3464 H H    . ASP A 1 229 ? -29.87471 -2.52413  33.31057  1.000 47.26112 ? 229 ASP A H    1 
ATOM   3465 H HA   . ASP A 1 229 ? -29.28485 -0.62997  31.59300  1.000 50.17709 ? 229 ASP A HA   1 
ATOM   3466 H HB2  . ASP A 1 229 ? -29.16735 -0.17465  33.86145  1.000 49.71513 ? 229 ASP A HB2  1 
ATOM   3467 H HB3  . ASP A 1 229 ? -27.99929 -1.23813  34.03478  1.000 49.71513 ? 229 ASP A HB3  1 
ATOM   3468 N N    . PHE A 1 230 ? -27.14758 -3.00561  31.79668  1.000 42.34226 ? 230 PHE A N    1 
ATOM   3469 C CA   . PHE A 1 230 ? -26.01804 -3.60209  31.09284  1.000 45.17264 ? 230 PHE A CA   1 
ATOM   3470 C C    . PHE A 1 230 ? -26.39564 -3.98013  29.66624  1.000 43.75721 ? 230 PHE A C    1 
ATOM   3471 O O    . PHE A 1 230 ? -25.60881 -3.77878  28.73331  1.000 44.71092 ? 230 PHE A O    1 
ATOM   3472 C CB   . PHE A 1 230 ? -25.51528 -4.82820  31.85335  1.000 41.24037 ? 230 PHE A CB   1 
ATOM   3473 C CG   . PHE A 1 230 ? -24.47079 -5.61030  31.11164  1.000 41.68613 ? 230 PHE A CG   1 
ATOM   3474 C CD1  . PHE A 1 230 ? -23.15448 -5.18047  31.08014  1.000 37.67702 ? 230 PHE A CD1  1 
ATOM   3475 C CD2  . PHE A 1 230 ? -24.80663 -6.77473  30.44212  1.000 45.17585 ? 230 PHE A CD2  1 
ATOM   3476 C CE1  . PHE A 1 230 ? -22.19204 -5.89911  30.39372  1.000 38.79568 ? 230 PHE A CE1  1 
ATOM   3477 C CE2  . PHE A 1 230 ? -23.85098 -7.49603  29.75563  1.000 41.00869 ? 230 PHE A CE2  1 
ATOM   3478 C CZ   . PHE A 1 230 ? -22.54225 -7.05822  29.73073  1.000 41.55698 ? 230 PHE A CZ   1 
ATOM   3479 H H    . PHE A 1 230 ? -27.44143 -3.46517  32.46156  1.000 50.83349 ? 230 PHE A H    1 
ATOM   3480 H HA   . PHE A 1 230 ? -25.29719 -2.95420  31.05390  1.000 54.22994 ? 230 PHE A HA   1 
ATOM   3481 H HB2  . PHE A 1 230 ? -25.12700 -4.53718  32.69326  1.000 49.51122 ? 230 PHE A HB2  1 
ATOM   3482 H HB3  . PHE A 1 230 ? -26.26495 -5.42021  32.02190  1.000 49.51122 ? 230 PHE A HB3  1 
ATOM   3483 H HD1  . PHE A 1 230 ? -22.91493 -4.39996  31.52547  1.000 45.23520 ? 230 PHE A HD1  1 
ATOM   3484 H HD2  . PHE A 1 230 ? -25.68690 -7.07450  30.45514  1.000 54.23380 ? 230 PHE A HD2  1 
ATOM   3485 H HE1  . PHE A 1 230 ? -21.31092 -5.60194  30.37895  1.000 46.57760 ? 230 PHE A HE1  1 
ATOM   3486 H HE2  . PHE A 1 230 ? -24.08878 -8.27687  29.30993  1.000 49.23321 ? 230 PHE A HE2  1 
ATOM   3487 H HZ   . PHE A 1 230 ? -21.89751 -7.54323  29.26814  1.000 49.89116 ? 230 PHE A HZ   1 
ATOM   3488 N N    . ASN A 1 231 ? -27.59953 -4.52203  29.47473  1.000 45.84651 ? 231 ASN A N    1 
ATOM   3489 C CA   . ASN A 1 231 ? -27.99580 -4.99410  28.15396  1.000 45.36416 ? 231 ASN A CA   1 
ATOM   3490 C C    . ASN A 1 231 ? -28.23957 -3.85604  27.17345  1.000 48.80009 ? 231 ASN A C    1 
ATOM   3491 O O    . ASN A 1 231 ? -28.15491 -4.07765  25.96063  1.000 49.60892 ? 231 ASN A O    1 
ATOM   3492 C CB   . ASN A 1 231 ? -29.23837 -5.87468  28.26785  1.000 46.79939 ? 231 ASN A CB   1 
ATOM   3493 C CG   . ASN A 1 231 ? -28.90535 -7.27164  28.74069  1.000 42.86528 ? 231 ASN A CG   1 
ATOM   3494 O OD1  . ASN A 1 231 ? -27.81937 -7.78429  28.46663  1.000 43.75674 ? 231 ASN A OD1  1 
ATOM   3495 N ND2  . ASN A 1 231 ? -29.82905 -7.89365  29.45791  1.000 40.22846 ? 231 ASN A ND2  1 
ATOM   3496 H H    . ASN A 1 231 ? -28.19541 -4.62534  30.08616  1.000 55.03859 ? 231 ASN A H    1 
ATOM   3497 H HA   . ASN A 1 231 ? -27.27940 -5.53729  27.78980  1.000 54.45977 ? 231 ASN A HA   1 
ATOM   3498 H HB2  . ASN A 1 231 ? -29.85256 -5.47790  28.90522  1.000 56.18205 ? 231 ASN A HB2  1 
ATOM   3499 H HB3  . ASN A 1 231 ? -29.66141 -5.94262  27.39761  1.000 56.18205 ? 231 ASN A HB3  1 
ATOM   3500 H HD21 . ASN A 1 231 ? -29.68381 -8.68993  29.74851  1.000 48.29693 ? 231 ASN A HD21 1 
ATOM   3501 H HD22 . ASN A 1 231 ? -30.57400 -7.50123  29.63298  1.000 48.29693 ? 231 ASN A HD22 1 
ATOM   3502 N N    . LEU A 1 232 ? -28.54559 -2.64994  27.65897  1.000 46.31381 ? 232 LEU A N    1 
ATOM   3503 C CA   . LEU A 1 232 ? -28.55103 -1.49584  26.76687  1.000 50.33516 ? 232 LEU A CA   1 
ATOM   3504 C C    . LEU A 1 232 ? -27.15209 -1.20188  26.24380  1.000 47.59241 ? 232 LEU A C    1 
ATOM   3505 O O    . LEU A 1 232 ? -27.00172 -0.64051  25.15289  1.000 49.83359 ? 232 LEU A O    1 
ATOM   3506 C CB   . LEU A 1 232 ? -29.11004 -0.26601  27.48205  1.000 54.06098 ? 232 LEU A CB   1 
ATOM   3507 C CG   . LEU A 1 232 ? -30.62105 -0.19109  27.71655  1.000 67.62221 ? 232 LEU A CG   1 
ATOM   3508 C CD1  . LEU A 1 232 ? -30.97772 1.13379   28.38947  1.000 56.86471 ? 232 LEU A CD1  1 
ATOM   3509 C CD2  . LEU A 1 232 ? -31.39231 -0.35699  26.41461  1.000 57.43554 ? 232 LEU A CD2  1 
ATOM   3510 H H    . LEU A 1 232 ? -28.74756 -2.48031  28.47753  1.000 55.59935 ? 232 LEU A H    1 
ATOM   3511 H HA   . LEU A 1 232 ? -29.13189 -1.68843  26.01426  1.000 60.42497 ? 232 LEU A HA   1 
ATOM   3512 H HB2  . LEU A 1 232 ? -28.69066 -0.21803  28.35539  1.000 64.89596 ? 232 LEU A HB2  1 
ATOM   3513 H HB3  . LEU A 1 232 ? -28.87154 0.51342   26.95622  1.000 64.89596 ? 232 LEU A HB3  1 
ATOM   3514 H HG   . LEU A 1 232 ? -30.88491 -0.91857  28.30140  1.000 81.16943 ? 232 LEU A HG   1 
ATOM   3515 H HD11 . LEU A 1 232 ? -31.94325 1.21556   28.43386  1.000 68.26043 ? 232 LEU A HD11 1 
ATOM   3516 H HD12 . LEU A 1 232 ? -30.60337 1.14435   29.28426  1.000 68.26043 ? 232 LEU A HD12 1 
ATOM   3517 H HD13 . LEU A 1 232 ? -30.60766 1.86280   27.86746  1.000 68.26043 ? 232 LEU A HD13 1 
ATOM   3518 H HD21 . LEU A 1 232 ? -32.18528 0.20089   26.44402  1.000 68.94543 ? 232 LEU A HD21 1 
ATOM   3519 H HD22 . LEU A 1 232 ? -30.82540 -0.08733  25.67515  1.000 68.94543 ? 232 LEU A HD22 1 
ATOM   3520 H HD23 . LEU A 1 232 ? -31.64625 -1.28778  26.31439  1.000 68.94543 ? 232 LEU A HD23 1 
ATOM   3521 N N    . VAL A 1 233 ? -26.12333 -1.56593  27.00808  1.000 46.54732 ? 233 VAL A N    1 
ATOM   3522 C CA   . VAL A 1 233 ? -24.75194 -1.39882  26.54488  1.000 44.87594 ? 233 VAL A CA   1 
ATOM   3523 C C    . VAL A 1 233 ? -24.33814 -2.57746  25.67313  1.000 45.41202 ? 233 VAL A C    1 
ATOM   3524 O O    . VAL A 1 233 ? -23.70714 -2.39800  24.62608  1.000 42.24241 ? 233 VAL A O    1 
ATOM   3525 C CB   . VAL A 1 233 ? -23.81158 -1.22023  27.75062  1.000 46.25384 ? 233 VAL A CB   1 
ATOM   3526 C CG1  . VAL A 1 233 ? -22.40694 -0.87047  27.28391  1.000 42.24767 ? 233 VAL A CG1  1 
ATOM   3527 C CG2  . VAL A 1 233 ? -24.35254 -0.15164  28.69462  1.000 48.68750 ? 233 VAL A CG2  1 
ATOM   3528 H H    . VAL A 1 233 ? -26.19348 -1.90970  27.79326  1.000 55.87957 ? 233 VAL A H    1 
ATOM   3529 H HA   . VAL A 1 233 ? -24.69744 -0.59638  26.00264  1.000 53.87391 ? 233 VAL A HA   1 
ATOM   3530 H HB   . VAL A 1 233 ? -23.76415 -2.05635  28.24005  1.000 55.52739 ? 233 VAL A HB   1 
ATOM   3531 H HG11 . VAL A 1 233 ? -21.85477 -0.68104  28.05859  1.000 50.71998 ? 233 VAL A HG11 1 
ATOM   3532 H HG12 . VAL A 1 233 ? -22.04091 -1.62259  26.79275  1.000 50.71998 ? 233 VAL A HG12 1 
ATOM   3533 H HG13 . VAL A 1 233 ? -22.45016 -0.08990  26.70967  1.000 50.71998 ? 233 VAL A HG13 1 
ATOM   3534 H HG21 . VAL A 1 233 ? -23.66209 0.08379   29.33396  1.000 58.44778 ? 233 VAL A HG21 1 
ATOM   3535 H HG22 . VAL A 1 233 ? -24.60404 0.62912   28.17687  1.000 58.44778 ? 233 VAL A HG22 1 
ATOM   3536 H HG23 . VAL A 1 233 ? -25.12757 -0.50396  29.15949  1.000 58.44778 ? 233 VAL A HG23 1 
ATOM   3537 N N    . ALA A 1 234 ? -24.69554 -3.79713  26.08197  1.000 45.95545 ? 234 ALA A N    1 
ATOM   3538 C CA   . ALA A 1 234 ? -24.40749 -4.97036  25.26338  1.000 42.43314 ? 234 ALA A CA   1 
ATOM   3539 C C    . ALA A 1 234 ? -24.92362 -4.78196  23.84327  1.000 46.03169 ? 234 ALA A C    1 
ATOM   3540 O O    . ALA A 1 234 ? -24.23354 -5.10204  22.86852  1.000 41.38600 ? 234 ALA A O    1 
ATOM   3541 C CB   . ALA A 1 234 ? -25.03106 -6.21142  25.90209  1.000 48.67472 ? 234 ALA A CB   1 
ATOM   3542 H H    . ALA A 1 234 ? -25.10100 -3.96863  26.82075  1.000 55.16931 ? 234 ALA A H    1 
ATOM   3543 H HA   . ALA A 1 234 ? -23.44773 -5.10434  25.22087  1.000 50.94255 ? 234 ALA A HA   1 
ATOM   3544 H HB1  . ALA A 1 234 ? -24.85073 -6.98065  25.33935  1.000 58.43245 ? 234 ALA A HB1  1 
ATOM   3545 H HB2  . ALA A 1 234 ? -24.64047 -6.34491  26.77989  1.000 58.43245 ? 234 ALA A HB2  1 
ATOM   3546 H HB3  . ALA A 1 234 ? -25.98841 -6.07783  25.98287  1.000 58.43245 ? 234 ALA A HB3  1 
ATOM   3547 N N    . MET A 1 235 ? -26.14543 -4.26504  23.71244  1.000 46.76807 ? 235 MET A N    1 
ATOM   3548 C CA   . MET A 1 235 ? -26.70303 -3.94028  22.40382  1.000 48.94547 ? 235 MET A CA   1 
ATOM   3549 C C    . MET A 1 235 ? -25.71237 -3.14301  21.56156  1.000 49.25590 ? 235 MET A C    1 
ATOM   3550 O O    . MET A 1 235 ? -25.31352 -3.56606  20.47156  1.000 47.20506 ? 235 MET A O    1 
ATOM   3551 C CB   . MET A 1 235 ? -28.00763 -3.15939  22.59878  1.000 53.38947 ? 235 MET A CB   1 
ATOM   3552 C CG   . MET A 1 235 ? -28.52023 -2.39722  21.37649  1.000 61.05740 ? 235 MET A CG   1 
ATOM   3553 S SD   . MET A 1 235 ? -29.70471 -1.11462  21.83633  1.000 88.14951 ? 235 MET A SD   1 
ATOM   3554 C CE   . MET A 1 235 ? -28.67821 -0.05205  22.85521  1.000 58.02848 ? 235 MET A CE   1 
ATOM   3555 H H    . MET A 1 235 ? -26.67315 -4.09252  24.36920  1.000 56.14446 ? 235 MET A H    1 
ATOM   3556 H HA   . MET A 1 235 ? -26.90566 -4.76385  21.93310  1.000 58.75734 ? 235 MET A HA   1 
ATOM   3557 H HB2  . MET A 1 235 ? -28.70090 -3.78678  22.85697  1.000 64.09014 ? 235 MET A HB2  1 
ATOM   3558 H HB3  . MET A 1 235 ? -27.86909 -2.50895  23.30493  1.000 64.09014 ? 235 MET A HB3  1 
ATOM   3559 H HG2  . MET A 1 235 ? -27.77240 -1.97364  20.92679  1.000 73.29166 ? 235 MET A HG2  1 
ATOM   3560 H HG3  . MET A 1 235 ? -28.96131 -3.01709  20.77474  1.000 73.29166 ? 235 MET A HG3  1 
ATOM   3561 H HE1  . MET A 1 235 ? -27.74926 -0.30703  22.74149  1.000 69.65696 ? 235 MET A HE1  1 
ATOM   3562 H HE2  . MET A 1 235 ? -28.80469 0.86897   22.57837  1.000 69.65696 ? 235 MET A HE2  1 
ATOM   3563 H HE3  . MET A 1 235 ? -28.93881 -0.15714  23.78361  1.000 69.65696 ? 235 MET A HE3  1 
ATOM   3564 N N    . LYS A 1 236 ? -25.30597 -1.97535  22.06059  1.000 49.49122 ? 236 LYS A N    1 
ATOM   3565 C CA   . LYS A 1 236 ? -24.45877 -1.07975  21.28035  1.000 48.02531 ? 236 LYS A CA   1 
ATOM   3566 C C    . LYS A 1 236 ? -23.18975 -1.76568  20.79214  1.000 47.26359 ? 236 LYS A C    1 
ATOM   3567 O O    . LYS A 1 236 ? -22.63370 -1.37452  19.75799  1.000 44.17724 ? 236 LYS A O    1 
ATOM   3568 C CB   . LYS A 1 236 ? -24.10914 0.14977   22.12389  1.000 48.47326 ? 236 LYS A CB   1 
ATOM   3569 C CG   . LYS A 1 236 ? -22.99131 1.01493   21.55879  1.000 56.01574 ? 236 LYS A CG   1 
ATOM   3570 C CD   . LYS A 1 236 ? -22.99334 2.40108   22.19939  1.000 63.89892 ? 236 LYS A CD   1 
ATOM   3571 C CE   . LYS A 1 236 ? -21.59351 2.96905   22.34731  1.000 55.04282 ? 236 LYS A CE   1 
ATOM   3572 N NZ   . LYS A 1 236 ? -20.76049 2.80539   21.12525  1.000 53.30595 ? 236 LYS A NZ   1 
ATOM   3573 H H    . LYS A 1 236 ? -25.50590 -1.68073  22.84342  1.000 59.41225 ? 236 LYS A H    1 
ATOM   3574 H HA   . LYS A 1 236 ? -24.94926 -0.79035  20.49514  1.000 57.65315 ? 236 LYS A HA   1 
ATOM   3575 H HB2  . LYS A 1 236 ? -24.89977 0.70677   22.19846  1.000 58.19069 ? 236 LYS A HB2  1 
ATOM   3576 H HB3  . LYS A 1 236 ? -23.83008 -0.14960  23.00333  1.000 58.19069 ? 236 LYS A HB3  1 
ATOM   3577 H HG2  . LYS A 1 236 ? -22.13556 0.59513   21.73870  1.000 67.24166 ? 236 LYS A HG2  1 
ATOM   3578 H HG3  . LYS A 1 236 ? -23.11532 1.11882   20.60238  1.000 67.24166 ? 236 LYS A HG3  1 
ATOM   3579 H HD2  . LYS A 1 236 ? -23.50768 3.00762   21.64399  1.000 76.70148 ? 236 LYS A HD2  1 
ATOM   3580 H HD3  . LYS A 1 236 ? -23.39002 2.34293   23.08266  1.000 76.70148 ? 236 LYS A HD3  1 
ATOM   3581 H HE2  . LYS A 1 236 ? -21.65784 3.91780   22.53868  1.000 66.07416 ? 236 LYS A HE2  1 
ATOM   3582 H HE3  . LYS A 1 236 ? -21.14477 2.51320   23.07651  1.000 66.07416 ? 236 LYS A HE3  1 
ATOM   3583 H HZ1  . LYS A 1 236 ? -21.27261 2.85420   20.39899  1.000 63.98992 ? 236 LYS A HZ1  1 
ATOM   3584 H HZ2  . LYS A 1 236 ? -20.14493 3.44711   21.08827  1.000 63.98992 ? 236 LYS A HZ2  1 
ATOM   3585 H HZ3  . LYS A 1 236 ? -20.35272 2.01441   21.13849  1.000 63.98992 ? 236 LYS A HZ3  1 
ATOM   3586 N N    . TYR A 1 237 ? -22.72883 -2.79686  21.50189  1.000 45.46185 ? 237 TYR A N    1 
ATOM   3587 C CA   . TYR A 1 237 ? -21.45658 -3.44372  21.20977  1.000 42.13775 ? 237 TYR A CA   1 
ATOM   3588 C C    . TYR A 1 237 ? -21.63139 -4.84420  20.63167  1.000 39.79450 ? 237 TYR A C    1 
ATOM   3589 O O    . TYR A 1 237 ? -20.70438 -5.65591  20.69744  1.000 38.04173 ? 237 TYR A O    1 
ATOM   3590 C CB   . TYR A 1 237 ? -20.60105 -3.48605  22.47677  1.000 41.31429 ? 237 TYR A CB   1 
ATOM   3591 C CG   . TYR A 1 237 ? -20.11267 -2.11972  22.91502  1.000 43.29019 ? 237 TYR A CG   1 
ATOM   3592 C CD1  . TYR A 1 237 ? -18.91174 -1.60830  22.44162  1.000 43.49215 ? 237 TYR A CD1  1 
ATOM   3593 C CD2  . TYR A 1 237 ? -20.85454 -1.33915  23.79519  1.000 46.06658 ? 237 TYR A CD2  1 
ATOM   3594 C CE1  . TYR A 1 237 ? -18.46029 -0.36151  22.83223  1.000 43.50062 ? 237 TYR A CE1  1 
ATOM   3595 C CE2  . TYR A 1 237 ? -20.41058 -0.09068  24.19199  1.000 44.42419 ? 237 TYR A CE2  1 
ATOM   3596 C CZ   . TYR A 1 237 ? -19.21296 0.39265   23.70768  1.000 44.85010 ? 237 TYR A CZ   1 
ATOM   3597 O OH   . TYR A 1 237 ? -18.76828 1.63617   24.09852  1.000 50.47381 ? 237 TYR A OH   1 
ATOM   3598 H H    . TYR A 1 237 ? -23.14574 -3.14355  22.16942  1.000 54.57700 ? 237 TYR A H    1 
ATOM   3599 H HA   . TYR A 1 237 ? -20.98640 -2.92035  20.54200  1.000 50.58808 ? 237 TYR A HA   1 
ATOM   3600 H HB2  . TYR A 1 237 ? -21.12895 -3.86000  23.19952  1.000 49.59993 ? 237 TYR A HB2  1 
ATOM   3601 H HB3  . TYR A 1 237 ? -19.82342 -4.04194  22.31188  1.000 49.59993 ? 237 TYR A HB3  1 
ATOM   3602 H HD1  . TYR A 1 237 ? -18.40164 -2.11391  21.85082  1.000 52.21335 ? 237 TYR A HD1  1 
ATOM   3603 H HD2  . TYR A 1 237 ? -21.66289 -1.66214  24.12254  1.000 55.30268 ? 237 TYR A HD2  1 
ATOM   3604 H HE1  . TYR A 1 237 ? -17.65349 -0.03315  22.50644  1.000 52.22352 ? 237 TYR A HE1  1 
ATOM   3605 H HE2  . TYR A 1 237 ? -20.91668 0.41992   24.78195  1.000 53.33180 ? 237 TYR A HE2  1 
ATOM   3606 H HH   . TYR A 1 237 ? -18.09589 1.85624   23.64568  1.000 60.59135 ? 237 TYR A HH   1 
ATOM   3607 N N    . ASN A 1 238 ? -22.78850 -5.12673  20.03972  1.000 40.43785 ? 238 ASN A N    1 
ATOM   3608 C CA   . ASN A 1 238 ? -23.13070 -6.45178  19.52358  1.000 40.20873 ? 238 ASN A CA   1 
ATOM   3609 C C    . ASN A 1 238 ? -22.69597 -7.54408  20.49586  1.000 35.94503 ? 238 ASN A C    1 
ATOM   3610 O O    . ASN A 1 238 ? -21.96408 -8.47595  20.15694  1.000 33.04044 ? 238 ASN A O    1 
ATOM   3611 C CB   . ASN A 1 238 ? -22.53331 -6.67534  18.13477  1.000 42.92547 ? 238 ASN A CB   1 
ATOM   3612 C CG   . ASN A 1 238 ? -23.29439 -5.93268  17.04760  1.000 53.21813 ? 238 ASN A CG   1 
ATOM   3613 O OD1  . ASN A 1 238 ? -24.49971 -5.70981  17.16368  1.000 59.00193 ? 238 ASN A OD1  1 
ATOM   3614 N ND2  . ASN A 1 238 ? -22.59337 -5.54576  15.98606  1.000 56.29394 ? 238 ASN A ND2  1 
ATOM   3615 H H    . ASN A 1 238 ? -23.41401 -4.54871  19.92048  1.000 48.54819 ? 238 ASN A H    1 
ATOM   3616 H HA   . ASN A 1 238 ? -24.09565 -6.50282  19.43899  1.000 48.27325 ? 238 ASN A HA   1 
ATOM   3617 H HB2  . ASN A 1 238 ? -21.61615 -6.35962  18.12950  1.000 51.53335 ? 238 ASN A HB2  1 
ATOM   3618 H HB3  . ASN A 1 238 ? -22.55933 -7.62249  17.92709  1.000 51.53335 ? 238 ASN A HB3  1 
ATOM   3619 H HD21 . ASN A 1 238 ? -22.98111 -5.12249  15.34568  1.000 67.57550 ? 238 ASN A HD21 1 
ATOM   3620 H HD22 . ASN A 1 238 ? -21.75222 -5.71879  15.93987  1.000 67.57550 ? 238 ASN A HD22 1 
ATOM   3621 N N    . TYR A 1 239 ? -23.16071 -7.40606  21.72998  1.000 31.40929 ? 239 TYR A N    1 
ATOM   3622 C CA   . TYR A 1 239 ? -23.03621 -8.44742  22.73539  1.000 31.91041 ? 239 TYR A CA   1 
ATOM   3623 C C    . TYR A 1 239 ? -24.37591 -9.14879  22.91424  1.000 35.82198 ? 239 TYR A C    1 
ATOM   3624 O O    . TYR A 1 239 ? -25.43898 -8.53993  22.76891  1.000 34.41507 ? 239 TYR A O    1 
ATOM   3625 C CB   . TYR A 1 239 ? -22.57516 -7.86959  24.07328  1.000 34.32386 ? 239 TYR A CB   1 
ATOM   3626 C CG   . TYR A 1 239 ? -21.08162 -7.90242  24.28730  1.000 33.16680 ? 239 TYR A CG   1 
ATOM   3627 C CD1  . TYR A 1 239 ? -20.21607 -7.34629  23.35880  1.000 29.28325 ? 239 TYR A CD1  1 
ATOM   3628 C CD2  . TYR A 1 239 ? -20.53982 -8.46926  25.43264  1.000 30.94848 ? 239 TYR A CD2  1 
ATOM   3629 C CE1  . TYR A 1 239 ? -18.85020 -7.36797  23.55418  1.000 33.74186 ? 239 TYR A CE1  1 
ATOM   3630 C CE2  . TYR A 1 239 ? -19.17480 -8.49452  25.63904  1.000 30.49708 ? 239 TYR A CE2  1 
ATOM   3631 C CZ   . TYR A 1 239 ? -18.33491 -7.94267  24.69614  1.000 30.94900 ? 239 TYR A CZ   1 
ATOM   3632 O OH   . TYR A 1 239 ? -16.97558 -7.96491  24.89892  1.000 26.57713 ? 239 TYR A OH   1 
ATOM   3633 H H    . TYR A 1 239 ? -23.56164 -6.70042  22.01445  1.000 37.71393 ? 239 TYR A H    1 
ATOM   3634 H HA   . TYR A 1 239 ? -22.37610 -9.09796  22.44911  1.000 38.31527 ? 239 TYR A HA   1 
ATOM   3635 H HB2  . TYR A 1 239 ? -22.85806 -6.94313  24.12371  1.000 41.21140 ? 239 TYR A HB2  1 
ATOM   3636 H HB3  . TYR A 1 239 ? -22.98492 -8.38100  24.78844  1.000 41.21140 ? 239 TYR A HB3  1 
ATOM   3637 H HD1  . TYR A 1 239 ? -20.56167 -6.95171  22.59084  1.000 35.16268 ? 239 TYR A HD1  1 
ATOM   3638 H HD2  . TYR A 1 239 ? -21.10573 -8.83825  26.07177  1.000 37.16095 ? 239 TYR A HD2  1 
ATOM   3639 H HE1  . TYR A 1 239 ? -18.28083 -6.99708  22.91923  1.000 40.51301 ? 239 TYR A HE1  1 
ATOM   3640 H HE2  . TYR A 1 239 ? -18.82469 -8.88124  26.40895  1.000 36.61927 ? 239 TYR A HE2  1 
ATOM   3641 H HH   . TYR A 1 239 ? -16.80607 -8.21554  25.68253  1.000 31.91534 ? 239 TYR A HH   1 
ATOM   3642 N N    . GLU A 1 240 ? -24.31450 -10.43846 23.22545  1.000 33.45797 ? 240 GLU A N    1 
ATOM   3643 C CA   . GLU A 1 240 ? -25.52891 -11.17954 23.52631  1.000 39.01417 ? 240 GLU A CA   1 
ATOM   3644 C C    . GLU A 1 240 ? -26.18667 -10.60395 24.77815  1.000 36.98463 ? 240 GLU A C    1 
ATOM   3645 O O    . GLU A 1 240 ? -25.49220 -10.27732 25.74773  1.000 32.99379 ? 240 GLU A O    1 
ATOM   3646 C CB   . GLU A 1 240 ? -25.21618 -12.66001 23.74499  1.000 40.35546 ? 240 GLU A CB   1 
ATOM   3647 C CG   . GLU A 1 240 ? -25.10380 -13.47515 22.46470  1.000 44.18998 ? 240 GLU A CG   1 
ATOM   3648 C CD   . GLU A 1 240 ? -26.45347 -13.91810 21.92027  1.000 57.17589 ? 240 GLU A CD   1 
ATOM   3649 O OE1  . GLU A 1 240 ? -27.47105 -13.77111 22.63170  1.000 55.01231 ? 240 GLU A OE1  1 
ATOM   3650 O OE2  . GLU A 1 240 ? -26.49618 -14.41767 20.77599  1.000 63.79620 ? 240 GLU A OE2  1 
ATOM   3651 H H    . GLU A 1 240 ? -23.59100 -10.90137 23.26865  1.000 40.17234 ? 240 GLU A H    1 
ATOM   3652 H HA   . GLU A 1 240 ? -26.14636 -11.10369 22.78206  1.000 46.83978 ? 240 GLU A HA   1 
ATOM   3653 H HB2  . GLU A 1 240 ? -24.36976 -12.73135 24.21337  1.000 48.44933 ? 240 GLU A HB2  1 
ATOM   3654 H HB3  . GLU A 1 240 ? -25.92520 -13.05011 24.27979  1.000 48.44933 ? 240 GLU A HB3  1 
ATOM   3655 H HG2  . GLU A 1 240 ? -24.66994 -12.93595 21.78505  1.000 53.05075 ? 240 GLU A HG2  1 
ATOM   3656 H HG3  . GLU A 1 240 ? -24.57795 -14.27054 22.64285  1.000 53.05075 ? 240 GLU A HG3  1 
ATOM   3657 N N    . PRO A 1 241 ? -27.51173 -10.46666 24.80248  1.000 38.60795 ? 241 PRO A N    1 
ATOM   3658 C CA   . PRO A 1 241 ? -28.16695 -10.03378 26.04118  1.000 36.90282 ? 241 PRO A CA   1 
ATOM   3659 C C    . PRO A 1 241 ? -27.92311 -11.03508 27.16107  1.000 38.91600 ? 241 PRO A C    1 
ATOM   3660 O O    . PRO A 1 241 ? -27.95441 -12.24995 26.95088  1.000 33.94681 ? 241 PRO A O    1 
ATOM   3661 C CB   . PRO A 1 241 ? -29.64984 -9.96131  25.65502  1.000 41.83688 ? 241 PRO A CB   1 
ATOM   3662 C CG   . PRO A 1 241 ? -29.65222 -9.79697  24.17470  1.000 38.53510 ? 241 PRO A CG   1 
ATOM   3663 C CD   . PRO A 1 241 ? -28.47394 -10.59114 23.69275  1.000 40.84697 ? 241 PRO A CD   1 
ATOM   3664 H HA   . PRO A 1 241 ? -27.85977 -9.15415  26.31097  1.000 44.30616 ? 241 PRO A HA   1 
ATOM   3665 H HB2  . PRO A 1 241 ? -30.09944 -10.78073 25.91445  1.000 50.22703 ? 241 PRO A HB2  1 
ATOM   3666 H HB3  . PRO A 1 241 ? -30.06790 -9.20158  26.08971  1.000 50.22703 ? 241 PRO A HB3  1 
ATOM   3667 H HG2  . PRO A 1 241 ? -30.47891 -10.14451 23.80498  1.000 46.26490 ? 241 PRO A HG2  1 
ATOM   3668 H HG3  . PRO A 1 241 ? -29.55493 -8.85931  23.94618  1.000 46.26490 ? 241 PRO A HG3  1 
ATOM   3669 H HD2  . PRO A 1 241 ? -28.71758 -11.51887 23.54835  1.000 49.03914 ? 241 PRO A HD2  1 
ATOM   3670 H HD3  . PRO A 1 241 ? -28.11177 -10.21233 22.87652  1.000 49.03914 ? 241 PRO A HD3  1 
ATOM   3671 N N    . LEU A 1 242 ? -27.66122 -10.51616 28.35758  1.000 34.85919 ? 242 LEU A N    1 
ATOM   3672 C CA   . LEU A 1 242 ? -27.48338 -11.36283 29.52643  1.000 36.94095 ? 242 LEU A CA   1 
ATOM   3673 C C    . LEU A 1 242 ? -28.83966 -11.67830 30.14948  1.000 38.36394 ? 242 LEU A C    1 
ATOM   3674 O O    . LEU A 1 242 ? -29.74765 -10.84128 30.16520  1.000 39.24177 ? 242 LEU A O    1 
ATOM   3675 C CB   . LEU A 1 242 ? -26.56979 -10.69532 30.55711  1.000 36.90669 ? 242 LEU A CB   1 
ATOM   3676 C CG   . LEU A 1 242 ? -25.83356 -11.68906 31.45994  1.000 37.91103 ? 242 LEU A CG   1 
ATOM   3677 C CD1  . LEU A 1 242 ? -24.69950 -12.37506 30.70030  1.000 36.99117 ? 242 LEU A CD1  1 
ATOM   3678 C CD2  . LEU A 1 242 ? -25.31347 -11.00900 32.71187  1.000 39.22950 ? 242 LEU A CD2  1 
ATOM   3679 H H    . LEU A 1 242 ? -27.58210 -9.67449  28.51550  1.000 41.85381 ? 242 LEU A H    1 
ATOM   3680 H HA   . LEU A 1 242 ? -27.06431 -12.19605 29.25995  1.000 44.35192 ? 242 LEU A HA   1 
ATOM   3681 H HB2  . LEU A 1 242 ? -25.90315 -10.16932 30.08827  1.000 44.31081 ? 242 LEU A HB2  1 
ATOM   3682 H HB3  . LEU A 1 242 ? -27.10738 -10.12046 31.12406  1.000 44.31081 ? 242 LEU A HB3  1 
ATOM   3683 H HG   . LEU A 1 242 ? -26.46072 -12.37413 31.73968  1.000 45.51602 ? 242 LEU A HG   1 
ATOM   3684 H HD11 . LEU A 1 242 ? -24.30880 -13.05914 31.26625  1.000 44.41218 ? 242 LEU A HD11 1 
ATOM   3685 H HD12 . LEU A 1 242 ? -25.05788 -12.77783 29.89392  1.000 44.41218 ? 242 LEU A HD12 1 
ATOM   3686 H HD13 . LEU A 1 242 ? -24.02851 -11.71365 30.46963  1.000 44.41218 ? 242 LEU A HD13 1 
ATOM   3687 H HD21 . LEU A 1 242 ? -24.62616 -11.56507 33.11099  1.000 47.09818 ? 242 LEU A HD21 1 
ATOM   3688 H HD22 . LEU A 1 242 ? -24.94219 -10.14576 32.47130  1.000 47.09818 ? 242 LEU A HD22 1 
ATOM   3689 H HD23 . LEU A 1 242 ? -26.04718 -10.89137 33.33536  1.000 47.09818 ? 242 LEU A HD23 1 
ATOM   3690 N N    . THR A 1 243 ? -28.96624 -12.89576 30.66990  1.000 36.99744 ? 243 THR A N    1 
ATOM   3691 C CA   . THR A 1 243 ? -30.21300 -13.39012 31.23214  1.000 37.63227 ? 243 THR A CA   1 
ATOM   3692 C C    . THR A 1 243 ? -29.96093 -13.87288 32.64965  1.000 36.23914 ? 243 THR A C    1 
ATOM   3693 O O    . THR A 1 243 ? -28.81583 -13.97647 33.09682  1.000 35.44185 ? 243 THR A O    1 
ATOM   3694 C CB   . THR A 1 243 ? -30.79458 -14.53292 30.39282  1.000 38.35194 ? 243 THR A CB   1 
ATOM   3695 O OG1  . THR A 1 243 ? -29.91643 -15.66382 30.45440  1.000 34.91406 ? 243 THR A OG1  1 
ATOM   3696 C CG2  . THR A 1 243 ? -30.95998 -14.09605 28.94826  1.000 39.15755 ? 243 THR A CG2  1 
ATOM   3697 H H    . THR A 1 243 ? -28.32464 -13.46714 30.70835  1.000 44.41970 ? 243 THR A H    1 
ATOM   3698 H HA   . THR A 1 243 ? -30.85951 -12.66738 31.25629  1.000 45.18150 ? 243 THR A HA   1 
ATOM   3699 H HB   . THR A 1 243 ? -31.66617 -14.78286 30.73744  1.000 46.04510 ? 243 THR A HB   1 
ATOM   3700 H HG1  . THR A 1 243 ? -30.17276 -16.25622 29.91685  1.000 41.91965 ? 243 THR A HG1  1 
ATOM   3701 H HG21 . THR A 1 243 ? -31.33584 -13.20254 28.91284  1.000 47.01184 ? 243 THR A HG21 1 
ATOM   3702 H HG22 . THR A 1 243 ? -30.09882 -14.09324 28.50184  1.000 47.01184 ? 243 THR A HG22 1 
ATOM   3703 H HG23 . THR A 1 243 ? -31.55370 -14.70599 28.48310  1.000 47.01184 ? 243 THR A HG23 1 
ATOM   3704 N N    . GLN A 1 244 ? -31.04859 -14.19254 33.35548  1.000 37.17761 ? 244 GLN A N    1 
ATOM   3705 C CA   . GLN A 1 244 ? -30.89674 -14.73005 34.70095  1.000 35.21210 ? 244 GLN A CA   1 
ATOM   3706 C C    . GLN A 1 244 ? -30.31675 -16.13581 34.66123  1.000 34.37785 ? 244 GLN A C    1 
ATOM   3707 O O    . GLN A 1 244 ? -29.57569 -16.52415 35.57024  1.000 36.15500 ? 244 GLN A O    1 
ATOM   3708 C CB   . GLN A 1 244 ? -32.23821 -14.71114 35.43287  1.000 38.01911 ? 244 GLN A CB   1 
ATOM   3709 C CG   . GLN A 1 244 ? -32.16511 -15.16778 36.87131  1.000 39.92872 ? 244 GLN A CG   1 
ATOM   3710 C CD   . GLN A 1 244 ? -31.20635 -14.33647 37.69619  1.000 34.09079 ? 244 GLN A CD   1 
ATOM   3711 O OE1  . GLN A 1 244 ? -31.29448 -13.10636 37.72615  1.000 35.33140 ? 244 GLN A OE1  1 
ATOM   3712 N NE2  . GLN A 1 244 ? -30.30046 -15.00717 38.39874  1.000 36.94382 ? 244 GLN A NE2  1 
ATOM   3713 H H    . GLN A 1 244 ? -31.86023 -14.10917 33.08367  1.000 44.63591 ? 244 GLN A H    1 
ATOM   3714 H HA   . GLN A 1 244 ? -30.28838 -14.16756 35.20533  1.000 42.27730 ? 244 GLN A HA   1 
ATOM   3715 H HB2  . GLN A 1 244 ? -32.58071 -13.80362 35.42923  1.000 45.64571 ? 244 GLN A HB2  1 
ATOM   3716 H HB3  . GLN A 1 244 ? -32.85338 -15.29977 34.96813  1.000 45.64571 ? 244 GLN A HB3  1 
ATOM   3717 H HG2  . GLN A 1 244 ? -33.04586 -15.09674 37.27149  1.000 47.93724 ? 244 GLN A HG2  1 
ATOM   3718 H HG3  . GLN A 1 244 ? -31.86267 -16.08908 36.89634  1.000 47.93724 ? 244 GLN A HG3  1 
ATOM   3719 H HE21 . GLN A 1 244 ? -30.28243 -15.86643 38.36809  1.000 44.35536 ? 244 GLN A HE21 1 
ATOM   3720 H HE22 . GLN A 1 244 ? -29.73193 -14.58219 38.88429  1.000 44.35536 ? 244 GLN A HE22 1 
ATOM   3721 N N    . ASP A 1 245 ? -30.63064 -16.90607 33.61795  1.000 35.29776 ? 245 ASP A N    1 
ATOM   3722 C CA   . ASP A 1 245 ? -29.96572 -18.18920 33.42639  1.000 38.72537 ? 245 ASP A CA   1 
ATOM   3723 C C    . ASP A 1 245 ? -28.45742 -18.00364 33.35439  1.000 34.51697 ? 245 ASP A C    1 
ATOM   3724 O O    . ASP A 1 245 ? -27.69861 -18.73807 33.99585  1.000 33.75460 ? 245 ASP A O    1 
ATOM   3725 C CB   . ASP A 1 245 ? -30.48274 -18.86436 32.15635  1.000 47.32553 ? 245 ASP A CB   1 
ATOM   3726 C CG   . ASP A 1 245 ? -31.93350 -19.27583 32.26554  1.000 50.33357 ? 245 ASP A CG   1 
ATOM   3727 O OD1  . ASP A 1 245 ? -32.31945 -19.82895 33.31873  1.000 47.75875 ? 245 ASP A OD1  1 
ATOM   3728 O OD2  . ASP A 1 245 ? -32.69375 -19.03970 31.30159  1.000 58.96674 ? 245 ASP A OD2  1 
ATOM   3729 H H    . ASP A 1 245 ? -31.21516 -16.71032 33.01827  1.000 42.38009 ? 245 ASP A H    1 
ATOM   3730 H HA   . ASP A 1 245 ? -30.17105 -18.76729 34.17776  1.000 46.49322 ? 245 ASP A HA   1 
ATOM   3731 H HB2  . ASP A 1 245 ? -30.40086 -18.24615 31.41338  1.000 56.81341 ? 245 ASP A HB2  1 
ATOM   3732 H HB3  . ASP A 1 245 ? -29.95659 -19.66097 31.98464  1.000 56.81341 ? 245 ASP A HB3  1 
ATOM   3733 N N    . HIS A 1 246 ? -28.00382 -17.03106 32.55887  1.000 32.65997 ? 246 HIS A N    1 
ATOM   3734 C CA   . HIS A 1 246 ? -26.58144 -16.70416 32.51846  1.000 35.12353 ? 246 HIS A CA   1 
ATOM   3735 C C    . HIS A 1 246 ? -26.05496 -16.36994 33.90921  1.000 29.92345 ? 246 HIS A C    1 
ATOM   3736 O O    . HIS A 1 246 ? -24.97672 -16.82713 34.30588  1.000 29.56967 ? 246 HIS A O    1 
ATOM   3737 C CB   . HIS A 1 246 ? -26.33874 -15.52950 31.57005  1.000 34.54530 ? 246 HIS A CB   1 
ATOM   3738 C CG   . HIS A 1 246 ? -26.68120 -15.81831 30.14254  1.000 33.72125 ? 246 HIS A CG   1 
ATOM   3739 N ND1  . HIS A 1 246 ? -27.17643 -14.85593 29.28971  1.000 35.44022 ? 246 HIS A ND1  1 
ATOM   3740 C CD2  . HIS A 1 246 ? -26.58921 -16.95552 29.41352  1.000 35.60720 ? 246 HIS A CD2  1 
ATOM   3741 C CE1  . HIS A 1 246 ? -27.38308 -15.38893 28.09929  1.000 35.25514 ? 246 HIS A CE1  1 
ATOM   3742 N NE2  . HIS A 1 246 ? -27.03400 -16.66191 28.14718  1.000 34.64462 ? 246 HIS A NE2  1 
ATOM   3743 H H    . HIS A 1 246 ? -28.49445 -16.55225 32.03963  1.000 39.21475 ? 246 HIS A H    1 
ATOM   3744 H HA   . HIS A 1 246 ? -26.09800 -17.47530 32.18300  1.000 42.17101 ? 246 HIS A HA   1 
ATOM   3745 H HB2  . HIS A 1 246 ? -26.88290 -14.77993 31.85803  1.000 41.47714 ? 246 HIS A HB2  1 
ATOM   3746 H HB3  . HIS A 1 246 ? -25.39933 -15.29042 31.60540  1.000 41.47714 ? 246 HIS A HB3  1 
ATOM   3747 H HD2  . HIS A 1 246 ? -26.28249 -17.78060 29.71365  1.000 42.75142 ? 246 HIS A HD2  1 
ATOM   3748 H HE1  . HIS A 1 246 ? -27.71739 -14.94388 27.35427  1.000 42.32894 ? 246 HIS A HE1  1 
ATOM   3749 H HE2  . HIS A 1 246 ? -27.07800 -17.21706 27.49184  1.000 41.59632 ? 246 HIS A HE2  1 
ATOM   3750 N N    . VAL A 1 247 ? -26.79356 -15.54592 34.65493  1.000 33.68277 ? 247 VAL A N    1 
ATOM   3751 C CA   . VAL A 1 247 ? -26.36800 -15.17430 36.00155  1.000 30.95555 ? 247 VAL A CA   1 
ATOM   3752 C C    . VAL A 1 247 ? -26.19554 -16.41447 36.87153  1.000 31.62652 ? 247 VAL A C    1 
ATOM   3753 O O    . VAL A 1 247 ? -25.20997 -16.54098 37.61026  1.000 30.21207 ? 247 VAL A O    1 
ATOM   3754 C CB   . VAL A 1 247 ? -27.37441 -14.18370 36.61584  1.000 33.60423 ? 247 VAL A CB   1 
ATOM   3755 C CG1  . VAL A 1 247 ? -27.03976 -13.92257 38.07310  1.000 31.21998 ? 247 VAL A CG1  1 
ATOM   3756 C CG2  . VAL A 1 247 ? -27.38744 -12.88566 35.82682  1.000 35.86837 ? 247 VAL A CG2  1 
ATOM   3757 H H    . VAL A 1 247 ? -27.53715 -15.19250 34.40638  1.000 40.44211 ? 247 VAL A H    1 
ATOM   3758 H HA   . VAL A 1 247 ? -25.50556 -14.73408 35.94403  1.000 37.16944 ? 247 VAL A HA   1 
ATOM   3759 H HB   . VAL A 1 247 ? -28.26297 -14.57070 36.57592  1.000 40.34785 ? 247 VAL A HB   1 
ATOM   3760 H HG11 . VAL A 1 247 ? -27.43750 -13.07983 38.34235  1.000 37.48676 ? 247 VAL A HG11 1 
ATOM   3761 H HG12 . VAL A 1 247 ? -27.39705 -14.64456 38.61344  1.000 37.48676 ? 247 VAL A HG12 1 
ATOM   3762 H HG13 . VAL A 1 247 ? -26.07586 -13.88032 38.17310  1.000 37.48676 ? 247 VAL A HG13 1 
ATOM   3763 H HG21 . VAL A 1 247 ? -28.11844 -12.33162 36.14235  1.000 43.06482 ? 247 VAL A HG21 1 
ATOM   3764 H HG22 . VAL A 1 247 ? -26.54328 -12.42675 35.95985  1.000 43.06482 ? 247 VAL A HG22 1 
ATOM   3765 H HG23 . VAL A 1 247 ? -27.50871 -13.08907 34.88617  1.000 43.06482 ? 247 VAL A HG23 1 
ATOM   3766 N N    . ASP A 1 248 ? -27.14726 -17.34979 36.79870  1.000 32.75034 ? 248 ASP A N    1 
ATOM   3767 C CA   . ASP A 1 248 ? -27.05619 -18.56212 37.60811  1.000 32.03064 ? 248 ASP A CA   1 
ATOM   3768 C C    . ASP A 1 248 ? -25.82754 -19.38037 37.23902  1.000 33.12370 ? 248 ASP A C    1 
ATOM   3769 O O    . ASP A 1 248 ? -25.13168 -19.90706 38.11600  1.000 30.01969 ? 248 ASP A O    1 
ATOM   3770 C CB   . ASP A 1 248 ? -28.31942 -19.40423 37.43529  1.000 33.58800 ? 248 ASP A CB   1 
ATOM   3771 C CG   . ASP A 1 248 ? -29.54365 -18.74530 38.03228  1.000 35.65397 ? 248 ASP A CG   1 
ATOM   3772 O OD1  . ASP A 1 248 ? -29.38018 -17.90234 38.94220  1.000 36.70431 ? 248 ASP A OD1  1 
ATOM   3773 O OD2  . ASP A 1 248 ? -30.66830 -19.07379 37.59403  1.000 35.51421 ? 248 ASP A OD2  1 
ATOM   3774 H H    . ASP A 1 248 ? -27.84387 -17.30582 36.29630  1.000 39.32319 ? 248 ASP A H    1 
ATOM   3775 H HA   . ASP A 1 248 ? -26.98419 -18.30688 38.54115  1.000 38.45954 ? 248 ASP A HA   1 
ATOM   3776 H HB2  . ASP A 1 248 ? -28.48252 -19.53998 36.48878  1.000 40.32838 ? 248 ASP A HB2  1 
ATOM   3777 H HB3  . ASP A 1 248 ? -28.19300 -20.25899 37.87609  1.000 40.32838 ? 248 ASP A HB3  1 
ATOM   3778 N N    . ILE A 1 249 ? -25.54948 -19.50157 35.94081  1.000 32.58479 ? 249 ILE A N    1 
ATOM   3779 C CA   . ILE A 1 249 ? -24.42412 -20.30866 35.48603  1.000 31.06968 ? 249 ILE A CA   1 
ATOM   3780 C C    . ILE A 1 249 ? -23.10980 -19.72481 35.98009  1.000 30.61351 ? 249 ILE A C    1 
ATOM   3781 O O    . ILE A 1 249 ? -22.13660 -20.45839 36.19686  1.000 29.52002 ? 249 ILE A O    1 
ATOM   3782 C CB   . ILE A 1 249 ? -24.48122 -20.43148 33.94967  1.000 34.60050 ? 249 ILE A CB   1 
ATOM   3783 C CG1  . ILE A 1 249 ? -25.55614 -21.44995 33.56073  1.000 31.47708 ? 249 ILE A CG1  1 
ATOM   3784 C CG2  . ILE A 1 249 ? -23.14186 -20.83823 33.38624  1.000 37.09176 ? 249 ILE A CG2  1 
ATOM   3785 C CD1  . ILE A 1 249 ? -26.28042 -21.12575 32.26792  1.000 36.54454 ? 249 ILE A CD1  1 
ATOM   3786 H H    . ILE A 1 249 ? -25.99561 -19.12794 35.30758  1.000 39.12453 ? 249 ILE A H    1 
ATOM   3787 H HA   . ILE A 1 249 ? -24.48851 -21.20161 35.85937  1.000 37.30640 ? 249 ILE A HA   1 
ATOM   3788 H HB   . ILE A 1 249 ? -24.70779 -19.56424 33.57891  1.000 41.54338 ? 249 ILE A HB   1 
ATOM   3789 H HG12 . ILE A 1 249 ? -25.13673 -22.31797 33.45335  1.000 37.79528 ? 249 ILE A HG12 1 
ATOM   3790 H HG13 . ILE A 1 249 ? -26.21891 -21.48694 34.26802  1.000 37.79528 ? 249 ILE A HG13 1 
ATOM   3791 H HG21 . ILE A 1 249 ? -23.22804 -20.96713 32.42871  1.000 44.53289 ? 249 ILE A HG21 1 
ATOM   3792 H HG22 . ILE A 1 249 ? -22.49645 -20.13754 33.56891  1.000 44.53289 ? 249 ILE A HG22 1 
ATOM   3793 H HG23 . ILE A 1 249 ? -22.86015 -21.66540 33.80733  1.000 44.53289 ? 249 ILE A HG23 1 
ATOM   3794 H HD11 . ILE A 1 249 ? -26.46523 -20.17394 32.23960  1.000 43.87623 ? 249 ILE A HD11 1 
ATOM   3795 H HD12 . ILE A 1 249 ? -25.71691 -21.37571 31.51899  1.000 43.87623 ? 249 ILE A HD12 1 
ATOM   3796 H HD13 . ILE A 1 249 ? -27.11145 -21.62511 32.23772  1.000 43.87623 ? 249 ILE A HD13 1 
ATOM   3797 N N    . LEU A 1 250 ? -23.05701 -18.41038 36.18357  1.000 33.34924 ? 250 LEU A N    1 
ATOM   3798 C CA   . LEU A 1 250 ? -21.86440 -17.77964 36.73074  1.000 34.43153 ? 250 LEU A CA   1 
ATOM   3799 C C    . LEU A 1 250 ? -21.78432 -17.89340 38.24832  1.000 36.13895 ? 250 LEU A C    1 
ATOM   3800 O O    . LEU A 1 250 ? -20.78358 -17.46333 38.83226  1.000 34.60536 ? 250 LEU A O    1 
ATOM   3801 C CB   . LEU A 1 250 ? -21.82199 -16.30874 36.30792  1.000 30.00979 ? 250 LEU A CB   1 
ATOM   3802 C CG   . LEU A 1 250 ? -21.64761 -16.09601 34.79959  1.000 27.01172 ? 250 LEU A CG   1 
ATOM   3803 C CD1  . LEU A 1 250 ? -21.94249 -14.65396 34.39869  1.000 28.70568 ? 250 LEU A CD1  1 
ATOM   3804 C CD2  . LEU A 1 250 ? -20.23543 -16.48903 34.37742  1.000 29.55382 ? 250 LEU A CD2  1 
ATOM   3805 H H    . LEU A 1 250 ? -23.69947 -17.86499 36.01215  1.000 40.04186 ? 250 LEU A H    1 
ATOM   3806 H HA   . LEU A 1 250 ? -21.07760 -18.21400 36.36580  1.000 41.34062 ? 250 LEU A HA   1 
ATOM   3807 H HB2  . LEU A 1 250 ? -22.65451 -15.88643 36.57148  1.000 36.03453 ? 250 LEU A HB2  1 
ATOM   3808 H HB3  . LEU A 1 250 ? -21.07600 -15.87918 36.75500  1.000 36.03453 ? 250 LEU A HB3  1 
ATOM   3809 H HG   . LEU A 1 250 ? -22.28349 -16.65974 34.33188  1.000 32.43685 ? 250 LEU A HG   1 
ATOM   3810 H HD11 . LEU A 1 250 ? -22.13925 -14.62405 33.44933  1.000 34.46960 ? 250 LEU A HD11 1 
ATOM   3811 H HD12 . LEU A 1 250 ? -22.70606 -14.33528 34.90495  1.000 34.46960 ? 250 LEU A HD12 1 
ATOM   3812 H HD13 . LEU A 1 250 ? -21.16529 -14.10699 34.59281  1.000 34.46960 ? 250 LEU A HD13 1 
ATOM   3813 H HD21 . LEU A 1 250 ? -20.08362 -16.19117 33.46686  1.000 35.48736 ? 250 LEU A HD21 1 
ATOM   3814 H HD22 . LEU A 1 250 ? -19.59824 -16.06636 34.97428  1.000 35.48736 ? 250 LEU A HD22 1 
ATOM   3815 H HD23 . LEU A 1 250 ? -20.14736 -17.45364 34.42893  1.000 35.48736 ? 250 LEU A HD23 1 
ATOM   3816 N N    . GLY A 1 251 ? -22.80203 -18.46649 38.89028  1.000 34.00655 ? 251 GLY A N    1 
ATOM   3817 C CA   . GLY A 1 251 ? -22.83133 -18.62667 40.32571  1.000 35.94231 ? 251 GLY A CA   1 
ATOM   3818 C C    . GLY A 1 251 ? -21.53361 -19.13742 40.92243  1.000 37.14110 ? 251 GLY A C    1 
ATOM   3819 O O    . GLY A 1 251 ? -20.91280 -18.47548 41.76078  1.000 37.19644 ? 251 GLY A O    1 
ATOM   3820 H H    . GLY A 1 251 ? -23.50212 -18.77620 38.49842  1.000 40.83064 ? 251 GLY A H    1 
ATOM   3821 H HA2  . GLY A 1 251 ? -23.02891 -17.76887 40.73319  1.000 43.15355 ? 251 GLY A HA2  1 
ATOM   3822 H HA3  . GLY A 1 251 ? -23.53293 -19.25527 40.55703  1.000 43.15355 ? 251 GLY A HA3  1 
ATOM   3823 N N    . PRO A 1 252 ? -21.10123 -20.33463 40.51258  1.000 37.21928 ? 252 PRO A N    1 
ATOM   3824 C CA   . PRO A 1 252 ? -19.88177 -20.90935 41.11022  1.000 37.33451 ? 252 PRO A CA   1 
ATOM   3825 C C    . PRO A 1 252 ? -18.68631 -19.97607 41.05289  1.000 40.30462 ? 252 PRO A C    1 
ATOM   3826 O O    . PRO A 1 252 ? -17.92772 -19.88025 42.02589  1.000 39.39082 ? 252 PRO A O    1 
ATOM   3827 C CB   . PRO A 1 252 ? -19.65344 -22.18068 40.28028  1.000 39.91316 ? 252 PRO A CB   1 
ATOM   3828 C CG   . PRO A 1 252 ? -21.00772 -22.53939 39.75200  1.000 39.30743 ? 252 PRO A CG   1 
ATOM   3829 C CD   . PRO A 1 252 ? -21.71359 -21.23526 39.51963  1.000 37.61808 ? 252 PRO A CD   1 
ATOM   3830 H HA   . PRO A 1 252 ? -20.05346 -21.15594 42.03251  1.000 44.82418 ? 252 PRO A HA   1 
ATOM   3831 H HB2  . PRO A 1 252 ? -19.03488 -21.99675 39.55609  1.000 47.91857 ? 252 PRO A HB2  1 
ATOM   3832 H HB3  . PRO A 1 252 ? -19.30217 -22.88645 40.84543  1.000 47.91857 ? 252 PRO A HB3  1 
ATOM   3833 H HG2  . PRO A 1 252 ? -20.91531 -23.03298 38.92210  1.000 47.19170 ? 252 PRO A HG2  1 
ATOM   3834 H HG3  . PRO A 1 252 ? -21.48278 -23.07575 40.40587  1.000 47.19170 ? 252 PRO A HG3  1 
ATOM   3835 H HD2  . PRO A 1 252 ? -21.55568 -20.91338 38.61832  1.000 45.16448 ? 252 PRO A HD2  1 
ATOM   3836 H HD3  . PRO A 1 252 ? -22.66637 -21.32584 39.67740  1.000 45.16448 ? 252 PRO A HD3  1 
ATOM   3837 N N    . LEU A 1 253 ? -18.49680 -19.28112 39.93082  1.000 38.48762 ? 253 LEU A N    1 
ATOM   3838 C CA   . LEU A 1 253 ? -17.41645 -18.30613 39.84560  1.000 38.95450 ? 253 LEU A CA   1 
ATOM   3839 C C    . LEU A 1 253 ? -17.71446 -17.09111 40.71385  1.000 37.39570 ? 253 LEU A C    1 
ATOM   3840 O O    . LEU A 1 253 ? -16.81265 -16.54503 41.36043  1.000 38.52236 ? 253 LEU A O    1 
ATOM   3841 C CB   . LEU A 1 253 ? -17.19960 -17.89886 38.38778  1.000 31.77626 ? 253 LEU A CB   1 
ATOM   3842 C CG   . LEU A 1 253 ? -16.84940 -19.05639 37.44706  1.000 35.50497 ? 253 LEU A CG   1 
ATOM   3843 C CD1  . LEU A 1 253 ? -16.75480 -18.57515 36.00577  1.000 32.14936 ? 253 LEU A CD1  1 
ATOM   3844 C CD2  . LEU A 1 253 ? -15.55025 -19.71896 37.87988  1.000 37.47035 ? 253 LEU A CD2  1 
ATOM   3845 H H    . LEU A 1 253 ? -18.97220 -19.35508 39.21799  1.000 46.20792 ? 253 LEU A H    1 
ATOM   3846 H HA   . LEU A 1 253 ? -16.59363 -18.70781 40.16577  1.000 46.76817 ? 253 LEU A HA   1 
ATOM   3847 H HB2  . LEU A 1 253 ? -18.01483 -17.48951 38.05802  1.000 38.15429 ? 253 LEU A HB2  1 
ATOM   3848 H HB3  . LEU A 1 253 ? -16.46989 -17.26080 38.35172  1.000 38.15429 ? 253 LEU A HB3  1 
ATOM   3849 H HG   . LEU A 1 253 ? -17.55568 -19.71987 37.49028  1.000 42.62874 ? 253 LEU A HG   1 
ATOM   3850 H HD11 . LEU A 1 253 ? -16.36686 -19.27901 35.46263  1.000 38.60201 ? 253 LEU A HD11 1 
ATOM   3851 H HD12 . LEU A 1 253 ? -17.64507 -18.36232 35.68481  1.000 38.60201 ? 253 LEU A HD12 1 
ATOM   3852 H HD13 . LEU A 1 253 ? -16.19359 -17.78467 35.97296  1.000 38.60201 ? 253 LEU A HD13 1 
ATOM   3853 H HD21 . LEU A 1 253 ? -15.28335 -20.36194 37.20442  1.000 44.98719 ? 253 LEU A HD21 1 
ATOM   3854 H HD22 . LEU A 1 253 ? -14.86594 -19.03846 37.97751  1.000 44.98719 ? 253 LEU A HD22 1 
ATOM   3855 H HD23 . LEU A 1 253 ? -15.69236 -20.16912 38.72726  1.000 44.98719 ? 253 LEU A HD23 1 
ATOM   3856 N N    . SER A 1 254 ? -18.97888 -16.66406 40.75301  1.000 38.67957 ? 254 SER A N    1 
ATOM   3857 C CA   . SER A 1 254 ? -19.36367 -15.55168 41.61180  1.000 40.41927 ? 254 SER A CA   1 
ATOM   3858 C C    . SER A 1 254 ? -19.17274 -15.87942 43.08673  1.000 39.55920 ? 254 SER A C    1 
ATOM   3859 O O    . SER A 1 254 ? -19.10740 -14.96094 43.91078  1.000 45.22700 ? 254 SER A O    1 
ATOM   3860 C CB   . SER A 1 254 ? -20.82201 -15.16812 41.34901  1.000 41.26097 ? 254 SER A CB   1 
ATOM   3861 O OG   . SER A 1 254 ? -21.07054 -13.82565 41.72597  1.000 41.33791 ? 254 SER A OG   1 
ATOM   3862 H H    . SER A 1 254 ? -19.62466 -17.00022 40.29523  1.000 46.43826 ? 254 SER A H    1 
ATOM   3863 H HA   . SER A 1 254 ? -18.80906 -14.78481 41.39919  1.000 48.52591 ? 254 SER A HA   1 
ATOM   3864 H HB2  . SER A 1 254 ? -21.00864 -15.26921 40.40252  1.000 49.53595 ? 254 SER A HB2  1 
ATOM   3865 H HB3  . SER A 1 254 ? -21.39926 -15.75225 41.86522  1.000 49.53595 ? 254 SER A HB3  1 
ATOM   3866 H HG   . SER A 1 254 ? -20.73741 -13.30193 41.15998  1.000 49.62827 ? 254 SER A HG   1 
ATOM   3867 N N    . ALA A 1 255 ? -19.07566 -17.16371 43.43400  1.000 41.65175 ? 255 ALA A N    1 
ATOM   3868 C CA   . ALA A 1 255 ? -18.92833 -17.60050 44.81668  1.000 40.42102 ? 255 ALA A CA   1 
ATOM   3869 C C    . ALA A 1 255 ? -17.48626 -17.88933 45.20899  1.000 47.12396 ? 255 ALA A C    1 
ATOM   3870 O O    . ALA A 1 255 ? -17.14752 -17.78328 46.39156  1.000 54.80676 ? 255 ALA A O    1 
ATOM   3871 C CB   . ALA A 1 255 ? -19.77301 -18.85486 45.06312  1.000 41.81216 ? 255 ALA A CB   1 
ATOM   3872 H H    . ALA A 1 255 ? -19.09326 -17.81400 42.87149  1.000 50.00488 ? 255 ALA A H    1 
ATOM   3873 H HA   . ALA A 1 255 ? -19.25535 -16.89844 45.40070  1.000 48.52801 ? 255 ALA A HA   1 
ATOM   3874 H HB1  . ALA A 1 255 ? -19.63989 -19.15066 45.97727  1.000 50.19737 ? 255 ALA A HB1  1 
ATOM   3875 H HB2  . ALA A 1 255 ? -20.70764 -18.63978 44.91783  1.000 50.19737 ? 255 ALA A HB2  1 
ATOM   3876 H HB3  . ALA A 1 255 ? -19.49379 -19.54975 44.44662  1.000 50.19737 ? 255 ALA A HB3  1 
ATOM   3877 N N    . GLN A 1 256 ? -16.63119 -18.25092 44.25018  1.000 43.13285 ? 256 GLN A N    1 
ATOM   3878 C CA   . GLN A 1 256 ? -15.22269 -18.49792 44.53443  1.000 44.44571 ? 256 GLN A CA   1 
ATOM   3879 C C    . GLN A 1 256 ? -14.40085 -17.21755 44.56480  1.000 46.69101 ? 256 GLN A C    1 
ATOM   3880 O O    . GLN A 1 256 ? -13.35155 -17.18337 45.21830  1.000 46.59565 ? 256 GLN A O    1 
ATOM   3881 C CB   . GLN A 1 256 ? -14.63169 -19.45273 43.49256  1.000 47.13906 ? 256 GLN A CB   1 
ATOM   3882 H H    . GLN A 1 256 ? -16.84458 -18.35995 43.42424  1.000 51.78219 ? 256 GLN A H    1 
ATOM   3883 H HA   . GLN A 1 256 ? -15.16229 -18.91687 45.40720  1.000 53.35763 ? 256 GLN A HA   1 
ATOM   3884 N N    . THR A 1 257 ? -14.84628 -16.17428 43.86334  1.000 44.79943 ? 257 THR A N    1 
ATOM   3885 C CA   . THR A 1 257 ? -14.22737 -14.85906 43.94632  1.000 43.34429 ? 257 THR A CA   1 
ATOM   3886 C C    . THR A 1 257 ? -14.91066 -13.94531 44.95253  1.000 42.17774 ? 257 THR A C    1 
ATOM   3887 O O    . THR A 1 257 ? -14.27945 -12.99826 45.43571  1.000 43.67825 ? 257 THR A O    1 
ATOM   3888 C CB   . THR A 1 257 ? -14.24557 -14.16859 42.57566  1.000 41.44727 ? 257 THR A CB   1 
ATOM   3889 O OG1  . THR A 1 257 ? -15.54840 -14.29319 41.98694  1.000 38.59225 ? 257 THR A OG1  1 
ATOM   3890 C CG2  . THR A 1 257 ? -13.19685 -14.77201 41.65175  1.000 43.52328 ? 257 THR A CG2  1 
ATOM   3891 H H    . THR A 1 257 ? -15.51608 -16.20654 43.32489  1.000 53.78210 ? 257 THR A H    1 
ATOM   3892 H HA   . THR A 1 257 ? -13.30248 -14.97644 44.21408  1.000 52.03593 ? 257 THR A HA   1 
ATOM   3893 H HB   . THR A 1 257 ? -14.03733 -13.22766 42.68602  1.000 49.75950 ? 257 THR A HB   1 
ATOM   3894 H HG1  . THR A 1 257 ? -15.71120 -15.09967 41.81757  1.000 46.33348 ? 257 THR A HG1  1 
ATOM   3895 H HG21 . THR A 1 257 ? -13.36836 -15.71877 41.52878  1.000 52.25071 ? 257 THR A HG21 1 
ATOM   3896 H HG22 . THR A 1 257 ? -13.22369 -14.33237 40.78752  1.000 52.25071 ? 257 THR A HG22 1 
ATOM   3897 H HG23 . THR A 1 257 ? -12.31289 -14.65938 42.03493  1.000 52.25071 ? 257 THR A HG23 1 
ATOM   3898 N N    . GLY A 1 258 ? -16.17658 -14.20282 45.27402  1.000 43.09242 ? 258 GLY A N    1 
ATOM   3899 C CA   . GLY A 1 258 ? -16.93174 -13.30503 46.12130  1.000 45.20349 ? 258 GLY A CA   1 
ATOM   3900 C C    . GLY A 1 258 ? -17.41584 -12.06031 45.42032  1.000 42.94769 ? 258 GLY A C    1 
ATOM   3901 O O    . GLY A 1 258 ? -17.79462 -11.09283 46.08717  1.000 43.80399 ? 258 GLY A O    1 
ATOM   3902 H H    . GLY A 1 258 ? -16.61614 -14.89354 45.01077  1.000 51.73369 ? 258 GLY A H    1 
ATOM   3903 H HA2  . GLY A 1 258 ? -17.70710 -13.77572 46.46504  1.000 54.26697 ? 258 GLY A HA2  1 
ATOM   3904 H HA3  . GLY A 1 258 ? -16.37292 -13.03135 46.86542  1.000 54.26697 ? 258 GLY A HA3  1 
ATOM   3905 N N    . ILE A 1 259 ? -17.41875 -12.05638 44.09039  1.000 40.64380 ? 259 ILE A N    1 
ATOM   3906 C CA   . ILE A 1 259 ? -17.79346 -10.89474 43.29395  1.000 38.65795 ? 259 ILE A CA   1 
ATOM   3907 C C    . ILE A 1 259 ? -19.17375 -11.15095 42.70724  1.000 39.63630 ? 259 ILE A C    1 
ATOM   3908 O O    . ILE A 1 259 ? -19.36584 -12.11080 41.94994  1.000 35.75999 ? 259 ILE A O    1 
ATOM   3909 C CB   . ILE A 1 259 ? -16.76741 -10.61729 42.18470  1.000 38.50605 ? 259 ILE A CB   1 
ATOM   3910 C CG1  . ILE A 1 259 ? -15.39137 -10.33969 42.79614  1.000 41.93351 ? 259 ILE A CG1  1 
ATOM   3911 C CG2  . ILE A 1 259 ? -17.22346 -9.44479  41.32633  1.000 36.30955 ? 259 ILE A CG2  1 
ATOM   3912 C CD1  . ILE A 1 259 ? -14.26006 -10.30902 41.79327  1.000 41.93689 ? 259 ILE A CD1  1 
ATOM   3913 H H    . ILE A 1 259 ? -17.20018 -12.73757 43.61311  1.000 48.79534 ? 259 ILE A H    1 
ATOM   3914 H HA   . ILE A 1 259 ? -17.84543 -10.11509 43.86870  1.000 46.41231 ? 259 ILE A HA   1 
ATOM   3915 H HB   . ILE A 1 259 ? -16.69889 -11.40274 41.61965  1.000 46.23004 ? 259 ILE A HB   1 
ATOM   3916 H HG12 . ILE A 1 259 ? -15.41672 -9.47602  43.23698  1.000 50.34299 ? 259 ILE A HG12 1 
ATOM   3917 H HG13 . ILE A 1 259 ? -15.19297 -11.03597 43.44168  1.000 50.34299 ? 259 ILE A HG13 1 
ATOM   3918 H HG21 . ILE A 1 259 ? -17.45440 -8.70105  41.90462  1.000 43.59424 ? 259 ILE A HG21 1 
ATOM   3919 H HG22 . ILE A 1 259 ? -16.50125 -9.18928  40.73132  1.000 43.59424 ? 259 ILE A HG22 1 
ATOM   3920 H HG23 . ILE A 1 259 ? -17.99840 -9.71465  40.80909  1.000 43.59424 ? 259 ILE A HG23 1 
ATOM   3921 H HD11 . ILE A 1 259 ? -14.38915 -9.55691  41.19448  1.000 50.34704 ? 259 ILE A HD11 1 
ATOM   3922 H HD12 . ILE A 1 259 ? -13.41964 -10.21336 42.26808  1.000 50.34704 ? 259 ILE A HD12 1 
ATOM   3923 H HD13 . ILE A 1 259 ? -14.26258 -11.13759 41.28892  1.000 50.34704 ? 259 ILE A HD13 1 
ATOM   3924 N N    . ALA A 1 260 ? -20.13193 -10.29430 43.05210  1.000 34.28118 ? 260 ALA A N    1 
ATOM   3925 C CA   . ALA A 1 260 ? -21.47111 -10.41985 42.49635  1.000 36.83227 ? 260 ALA A CA   1 
ATOM   3926 C C    . ALA A 1 260 ? -21.42723 -10.27764 40.97815  1.000 34.56369 ? 260 ALA A C    1 
ATOM   3927 O O    . ALA A 1 260 ? -20.59912 -9.55219  40.42087  1.000 32.40257 ? 260 ALA A O    1 
ATOM   3928 C CB   . ALA A 1 260 ? -22.40075 -9.37035  43.10606  1.000 33.85018 ? 260 ALA A CB   1 
ATOM   3929 H H    . ALA A 1 260 ? -20.03168 -9.63923  43.60021  1.000 41.16020 ? 260 ALA A H    1 
ATOM   3930 H HA   . ALA A 1 260 ? -21.83378 -11.29416 42.70837  1.000 44.22151 ? 260 ALA A HA   1 
ATOM   3931 H HB1  . ALA A 1 260 ? -23.29000 -9.48251  42.73517  1.000 40.64300 ? 260 ALA A HB1  1 
ATOM   3932 H HB2  . ALA A 1 260 ? -22.42592 -9.49152  44.06814  1.000 40.64300 ? 260 ALA A HB2  1 
ATOM   3933 H HB3  . ALA A 1 260 ? -22.06242 -8.48666  42.89271  1.000 40.64300 ? 260 ALA A HB3  1 
ATOM   3934 N N    . VAL A 1 261 ? -22.33315 -10.98972 40.30505  1.000 34.57607 ? 261 VAL A N    1 
ATOM   3935 C CA   . VAL A 1 261 ? -22.31619 -11.02243 38.84499  1.000 32.12058 ? 261 VAL A CA   1 
ATOM   3936 C C    . VAL A 1 261 ? -22.57811 -9.63588  38.27181  1.000 32.87801 ? 261 VAL A C    1 
ATOM   3937 O O    . VAL A 1 261 ? -21.95953 -9.23450  37.27828  1.000 26.30560 ? 261 VAL A O    1 
ATOM   3938 C CB   . VAL A 1 261 ? -23.33097 -12.05805 38.32453  1.000 29.30202 ? 261 VAL A CB   1 
ATOM   3939 C CG1  . VAL A 1 261 ? -23.67262 -11.79649 36.86635  1.000 30.31713 ? 261 VAL A CG1  1 
ATOM   3940 C CG2  . VAL A 1 261 ? -22.76952 -13.46322 38.49321  1.000 32.09673 ? 261 VAL A CG2  1 
ATOM   3941 H H    . VAL A 1 261 ? -22.95923 -11.45601 40.66587  1.000 41.51406 ? 261 VAL A H    1 
ATOM   3942 H HA   . VAL A 1 261 ? -21.43231 -11.29651 38.55422  1.000 38.56748 ? 261 VAL A HA   1 
ATOM   3943 H HB   . VAL A 1 261 ? -24.14940 -11.98301 38.83974  1.000 35.18520 ? 261 VAL A HB   1 
ATOM   3944 H HG11 . VAL A 1 261 ? -22.87823 -11.48145 36.40747  1.000 36.40334 ? 261 VAL A HG11 1 
ATOM   3945 H HG12 . VAL A 1 261 ? -23.98296 -12.62167 36.46179  1.000 36.40334 ? 261 VAL A HG12 1 
ATOM   3946 H HG13 . VAL A 1 261 ? -24.36959 -11.12337 36.82113  1.000 36.40334 ? 261 VAL A HG13 1 
ATOM   3947 H HG21 . VAL A 1 261 ? -23.42243 -14.10480 38.17231  1.000 38.53885 ? 261 VAL A HG21 1 
ATOM   3948 H HG22 . VAL A 1 261 ? -21.95035 -13.53977 37.97939  1.000 38.53885 ? 261 VAL A HG22 1 
ATOM   3949 H HG23 . VAL A 1 261 ? -22.58641 -13.61944 39.43287  1.000 38.53885 ? 261 VAL A HG23 1 
ATOM   3950 N N    . LEU A 1 262 ? -23.49582 -8.88104  38.88038  1.000 29.00800 ? 262 LEU A N    1 
ATOM   3951 C CA   . LEU A 1 262 ? -23.77897 -7.54140  38.37506  1.000 33.71981 ? 262 LEU A CA   1 
ATOM   3952 C C    . LEU A 1 262 ? -22.61738 -6.58722  38.62716  1.000 27.59040 ? 262 LEU A C    1 
ATOM   3953 O O    . LEU A 1 262 ? -22.44943 -5.61077  37.88615  1.000 28.87992 ? 262 LEU A O    1 
ATOM   3954 C CB   . LEU A 1 262 ? -25.06317 -7.00190  39.00329  1.000 34.40730 ? 262 LEU A CB   1 
ATOM   3955 C CG   . LEU A 1 262 ? -26.35010 -7.73124  38.60158  1.000 35.52763 ? 262 LEU A CG   1 
ATOM   3956 C CD1  . LEU A 1 262 ? -27.56570 -7.06180  39.22789  1.000 33.65256 ? 262 LEU A CD1  1 
ATOM   3957 C CD2  . LEU A 1 262 ? -26.49808 -7.78663  37.08561  1.000 34.18126 ? 262 LEU A CD2  1 
ATOM   3958 H H    . LEU A 1 262 ? -23.95501 -9.11598  39.56852  1.000 34.83238 ? 262 LEU A H    1 
ATOM   3959 H HA   . LEU A 1 262 ? -23.91742 -7.59297  37.41638  1.000 40.48655 ? 262 LEU A HA   1 
ATOM   3960 H HB2  . LEU A 1 262 ? -24.98169 -7.06833  39.96758  1.000 41.31154 ? 262 LEU A HB2  1 
ATOM   3961 H HB3  . LEU A 1 262 ? -25.16314 -6.07312  38.74200  1.000 41.31154 ? 262 LEU A HB3  1 
ATOM   3962 H HG   . LEU A 1 262 ? -26.30128 -8.64266  38.92996  1.000 42.65593 ? 262 LEU A HG   1 
ATOM   3963 H HD11 . LEU A 1 262 ? -28.33161 -7.65019  39.13795  1.000 40.40585 ? 262 LEU A HD11 1 
ATOM   3964 H HD12 . LEU A 1 262 ? -27.38559 -6.89437  40.16621  1.000 40.40585 ? 262 LEU A HD12 1 
ATOM   3965 H HD13 . LEU A 1 262 ? -27.73633 -6.22429  38.76925  1.000 40.40585 ? 262 LEU A HD13 1 
ATOM   3966 H HD21 . LEU A 1 262 ? -25.85910 -8.42335  36.72898  1.000 41.04028 ? 262 LEU A HD21 1 
ATOM   3967 H HD22 . LEU A 1 262 ? -27.40079 -8.06586  36.86641  1.000 41.04028 ? 262 LEU A HD22 1 
ATOM   3968 H HD23 . LEU A 1 262 ? -26.32634 -6.90510  36.71912  1.000 41.04028 ? 262 LEU A HD23 1 
ATOM   3969 N N    . ASP A 1 263 ? -21.81036 -6.84694  39.65909  1.000 27.07678 ? 263 ASP A N    1 
ATOM   3970 C CA   . ASP A 1 263 ? -20.59382 -6.06574  39.85385  1.000 32.09427 ? 263 ASP A CA   1 
ATOM   3971 C C    . ASP A 1 263 ? -19.58749 -6.34487  38.74248  1.000 26.22280 ? 263 ASP A C    1 
ATOM   3972 O O    . ASP A 1 263 ? -18.96491 -5.41790  38.21294  1.000 26.93661 ? 263 ASP A O    1 
ATOM   3973 C CB   . ASP A 1 263 ? -19.97904 -6.37280  41.22214  1.000 32.09786 ? 263 ASP A CB   1 
ATOM   3974 C CG   . ASP A 1 263 ? -20.80712 -5.83417  42.38260  1.000 32.53348 ? 263 ASP A CG   1 
ATOM   3975 O OD1  . ASP A 1 263 ? -21.90807 -5.28981  42.15029  1.000 27.26723 ? 263 ASP A OD1  1 
ATOM   3976 O OD2  . ASP A 1 263 ? -20.34712 -5.95819  43.53743  1.000 31.93222 ? 263 ASP A OD2  1 
ATOM   3977 H H    . ASP A 1 263 ? -21.94372 -7.45888  40.24845  1.000 32.51492 ? 263 ASP A H    1 
ATOM   3978 H HA   . ASP A 1 263 ? -20.81964 -5.12258  39.83523  1.000 38.53590 ? 263 ASP A HA   1 
ATOM   3979 H HB2  . ASP A 1 263 ? -19.90802 -7.33451  41.32690  1.000 38.54021 ? 263 ASP A HB2  1 
ATOM   3980 H HB3  . ASP A 1 263 ? -19.09886 -5.96796  41.27001  1.000 38.54021 ? 263 ASP A HB3  1 
ATOM   3981 N N    . MET A 1 264 ? -19.41207 -7.61724  38.37516  1.000 27.36354 ? 264 MET A N    1 
ATOM   3982 C CA   . MET A 1 264 ? -18.53549 -7.93673  37.25278  1.000 31.05071 ? 264 MET A CA   1 
ATOM   3983 C C    . MET A 1 264 ? -19.08095 -7.37353  35.94568  1.000 25.62076 ? 264 MET A C    1 
ATOM   3984 O O    . MET A 1 264 ? -18.30479 -6.96108  35.07621  1.000 29.89796 ? 264 MET A O    1 
ATOM   3985 C CB   . MET A 1 264 ? -18.34345 -9.45048  37.14483  1.000 30.12235 ? 264 MET A CB   1 
ATOM   3986 C CG   . MET A 1 264 ? -17.23311 -9.85118  36.18534  1.000 29.78007 ? 264 MET A CG   1 
ATOM   3987 S SD   . MET A 1 264 ? -15.59563 -9.28335  36.71011  1.000 33.45190 ? 264 MET A SD   1 
ATOM   3988 C CE   . MET A 1 264 ? -15.06699 -10.66840 37.71140  1.000 33.38246 ? 264 MET A CE   1 
ATOM   3989 H H    . MET A 1 264 ? -19.78116 -8.29668  38.75163  1.000 32.85902 ? 264 MET A H    1 
ATOM   3990 H HA   . MET A 1 264 ? -17.66400 -7.54537  37.42089  1.000 37.28363 ? 264 MET A HA   1 
ATOM   3991 H HB2  . MET A 1 264 ? -18.12059 -9.80127  38.02128  1.000 36.16960 ? 264 MET A HB2  1 
ATOM   3992 H HB3  . MET A 1 264 ? -19.16903 -9.84917  36.82801  1.000 36.16960 ? 264 MET A HB3  1 
ATOM   3993 H HG2  . MET A 1 264 ? -17.20668 -10.81875 36.12187  1.000 35.75886 ? 264 MET A HG2  1 
ATOM   3994 H HG3  . MET A 1 264 ? -17.41674 -9.46645  35.31404  1.000 35.75886 ? 264 MET A HG3  1 
ATOM   3995 H HE1  . MET A 1 264 ? -14.86603 -11.41918 37.13101  1.000 40.08173 ? 264 MET A HE1  1 
ATOM   3996 H HE2  . MET A 1 264 ? -14.27443 -10.41383 38.20934  1.000 40.08173 ? 264 MET A HE2  1 
ATOM   3997 H HE3  . MET A 1 264 ? -15.78055 -10.90570 38.32412  1.000 40.08173 ? 264 MET A HE3  1 
ATOM   3998 N N    . CYS A 1 265 ? -20.40605 -7.34318  35.78552  1.000 29.02596 ? 265 CYS A N    1 
ATOM   3999 C CA   . CYS A 1 265 ? -20.98591 -6.67924  34.62298  1.000 28.31389 ? 265 CYS A CA   1 
ATOM   4000 C C    . CYS A 1 265 ? -20.59858 -5.20906  34.58552  1.000 28.92847 ? 265 CYS A C    1 
ATOM   4001 O O    . CYS A 1 265 ? -20.38953 -4.63951  33.50719  1.000 29.68095 ? 265 CYS A O    1 
ATOM   4002 C CB   . CYS A 1 265 ? -22.50524 -6.81922  34.63856  1.000 31.50127 ? 265 CYS A CB   1 
ATOM   4003 S SG   . CYS A 1 265 ? -23.09687 -8.50464  34.38418  1.000 31.36015 ? 265 CYS A SG   1 
ATOM   4004 H H    . CYS A 1 265 ? -20.97761 -7.69247  36.32490  1.000 34.85393 ? 265 CYS A H    1 
ATOM   4005 H HA   . CYS A 1 265 ? -20.64988 -7.10873  33.82078  1.000 33.99945 ? 265 CYS A HA   1 
ATOM   4006 H HB2  . CYS A 1 265 ? -22.83522 -6.51851  35.49972  1.000 37.82430 ? 265 CYS A HB2  1 
ATOM   4007 H HB3  . CYS A 1 265 ? -22.87439 -6.26798  33.93092  1.000 37.82430 ? 265 CYS A HB3  1 
ATOM   4008 H HG   . CYS A 1 265 ? -24.29533 -8.51129  34.44460  1.000 37.65496 ? 265 CYS A HG   1 
ATOM   4009 N N    . ALA A 1 266 ? -20.51030 -4.57369  35.75634  1.000 27.43122 ? 266 ALA A N    1 
ATOM   4010 C CA   . ALA A 1 266 ? -20.11323 -3.17132  35.80504  1.000 28.79781 ? 266 ALA A CA   1 
ATOM   4011 C C    . ALA A 1 266 ? -18.68617 -2.98906  35.30579  1.000 28.67971 ? 266 ALA A C    1 
ATOM   4012 O O    . ALA A 1 266 ? -18.38006 -2.00556  34.62184  1.000 28.70203 ? 266 ALA A O    1 
ATOM   4013 C CB   . ALA A 1 266 ? -20.25929 -2.63547  37.22785  1.000 31.76091 ? 266 ALA A CB   1 
ATOM   4014 H H    . ALA A 1 266 ? -20.67268 -4.92776  36.52307  1.000 32.94025 ? 266 ALA A H    1 
ATOM   4015 H HA   . ALA A 1 266 ? -20.70119 -2.65683  35.23014  1.000 34.58015 ? 266 ALA A HA   1 
ATOM   4016 H HB1  . ALA A 1 266 ? -20.02205 -1.69498  37.23701  1.000 38.13587 ? 266 ALA A HB1  1 
ATOM   4017 H HB2  . ALA A 1 266 ? -21.17916 -2.74738  37.51457  1.000 38.13587 ? 266 ALA A HB2  1 
ATOM   4018 H HB3  . ALA A 1 266 ? -19.66726 -3.13168  37.81451  1.000 38.13587 ? 266 ALA A HB3  1 
ATOM   4019 N N    . SER A 1 267 ? -17.79729 -3.92722  35.63671  1.000 31.91231 ? 267 SER A N    1 
ATOM   4020 C CA   . SER A 1 267 ? -16.43844 -3.87010  35.10858  1.000 34.60171 ? 267 SER A CA   1 
ATOM   4021 C C    . SER A 1 267 ? -16.44074 -4.03445  33.59398  1.000 31.60610 ? 267 SER A C    1 
ATOM   4022 O O    . SER A 1 267 ? -15.77771 -3.28043  32.87169  1.000 30.81830 ? 267 SER A O    1 
ATOM   4023 C CB   . SER A 1 267 ? -15.57711 -4.94663  35.76789  1.000 33.34443 ? 267 SER A CB   1 
ATOM   4024 O OG   . SER A 1 267 ? -15.29909 -4.61845  37.11563  1.000 34.89813 ? 267 SER A OG   1 
ATOM   4025 H H    . SER A 1 267 ? -17.95428 -4.59461  36.15589  1.000 38.31755 ? 267 SER A H    1 
ATOM   4026 H HA   . SER A 1 267 ? -16.05191 -3.00593  35.32003  1.000 41.54483 ? 267 SER A HA   1 
ATOM   4027 H HB2  . SER A 1 267 ? -16.05315 -5.79135  35.74099  1.000 40.03609 ? 267 SER A HB2  1 
ATOM   4028 H HB3  . SER A 1 267 ? -14.74048 -5.02170  35.28279  1.000 40.03609 ? 267 SER A HB3  1 
ATOM   4029 H HG   . SER A 1 267 ? -14.72293 -4.00814  37.14973  1.000 41.90053 ? 267 SER A HG   1 
ATOM   4030 N N    . LEU A 1 268 ? -17.19012 -5.01967  33.09429  1.000 29.73610 ? 268 LEU A N    1 
ATOM   4031 C CA   . LEU A 1 268 ? -17.26297 -5.23763  31.65300  1.000 32.46227 ? 268 LEU A CA   1 
ATOM   4032 C C    . LEU A 1 268 ? -17.79089 -4.00048  30.93895  1.000 31.73819 ? 268 LEU A C    1 
ATOM   4033 O O    . LEU A 1 268 ? -17.26470 -3.60175  29.89246  1.000 28.66813 ? 268 LEU A O    1 
ATOM   4034 C CB   . LEU A 1 268 ? -18.14645 -6.44980  31.35624  1.000 27.30816 ? 268 LEU A CB   1 
ATOM   4035 C CG   . LEU A 1 268 ? -18.32276 -6.81700  29.88139  1.000 27.00074 ? 268 LEU A CG   1 
ATOM   4036 C CD1  . LEU A 1 268 ? -16.97466 -6.91464  29.18260  1.000 29.70519 ? 268 LEU A CD1  1 
ATOM   4037 C CD2  . LEU A 1 268 ? -19.08453 -8.12769  29.75450  1.000 28.94873 ? 268 LEU A CD2  1 
ATOM   4038 H H    . LEU A 1 268 ? -17.65901 -5.56757  33.56285  1.000 35.70609 ? 268 LEU A H    1 
ATOM   4039 H HA   . LEU A 1 268 ? -16.37319 -5.42299  31.31414  1.000 38.97750 ? 268 LEU A HA   1 
ATOM   4040 H HB2  . LEU A 1 268 ? -17.75784 -7.22091  31.79813  1.000 32.79257 ? 268 LEU A HB2  1 
ATOM   4041 H HB3  . LEU A 1 268 ? -19.03044 -6.27284  31.71421  1.000 32.79257 ? 268 LEU A HB3  1 
ATOM   4042 H HG   . LEU A 1 268 ? -18.83442 -6.12003  29.44170  1.000 32.42366 ? 268 LEU A HG   1 
ATOM   4043 H HD11 . LEU A 1 268 ? -17.09590 -7.34332  28.32096  1.000 35.66900 ? 268 LEU A HD11 1 
ATOM   4044 H HD12 . LEU A 1 268 ? -16.61695 -6.02135  29.06022  1.000 35.66900 ? 268 LEU A HD12 1 
ATOM   4045 H HD13 . LEU A 1 268 ? -16.37173 -7.44005  29.73154  1.000 35.66900 ? 268 LEU A HD13 1 
ATOM   4046 H HD21 . LEU A 1 268 ? -19.98863 -8.00049  30.08212  1.000 34.76125 ? 268 LEU A HD21 1 
ATOM   4047 H HD22 . LEU A 1 268 ? -19.10495 -8.39203  28.82144  1.000 34.76125 ? 268 LEU A HD22 1 
ATOM   4048 H HD23 . LEU A 1 268 ? -18.63443 -8.80680  30.28092  1.000 34.76125 ? 268 LEU A HD23 1 
ATOM   4049 N N    . LYS A 1 269 ? -18.83058 -3.37890  31.49540  1.000 32.29172 ? 269 LYS A N    1 
ATOM   4050 C CA   . LYS A 1 269 ? -19.37362 -2.15376  30.92046  1.000 38.07317 ? 269 LYS A CA   1 
ATOM   4051 C C    . LYS A 1 269 ? -18.28539 -1.10121  30.73438  1.000 33.65313 ? 269 LYS A C    1 
ATOM   4052 O O    . LYS A 1 269 ? -18.17417 -0.48489  29.66830  1.000 35.14047 ? 269 LYS A O    1 
ATOM   4053 C CB   . LYS A 1 269 ? -20.49427 -1.63646  31.82329  1.000 36.39372 ? 269 LYS A CB   1 
ATOM   4054 C CG   . LYS A 1 269 ? -21.05624 -0.28455  31.45193  1.000 43.31326 ? 269 LYS A CG   1 
ATOM   4055 C CD   . LYS A 1 269 ? -22.16741 0.09567   32.41867  1.000 43.82783 ? 269 LYS A CD   1 
ATOM   4056 C CE   . LYS A 1 269 ? -22.71977 1.48299   32.14674  1.000 50.12203 ? 269 LYS A CE   1 
ATOM   4057 N NZ   . LYS A 1 269 ? -23.84357 1.80055   33.07622  1.000 55.38100 ? 269 LYS A NZ   1 
ATOM   4058 H H    . LYS A 1 269 ? -19.23765 -3.64626  32.20421  1.000 38.77284 ? 269 LYS A H    1 
ATOM   4059 H HA   . LYS A 1 269 ? -19.74617 -2.34131  30.04471  1.000 45.71058 ? 269 LYS A HA   1 
ATOM   4060 H HB2  . LYS A 1 269 ? -21.22692 -2.27152  31.79449  1.000 43.69524 ? 269 LYS A HB2  1 
ATOM   4061 H HB3  . LYS A 1 269 ? -20.15024 -1.56763  32.72762  1.000 43.69524 ? 269 LYS A HB3  1 
ATOM   4062 H HG2  . LYS A 1 269 ? -20.35690 0.38580   31.50143  1.000 51.99869 ? 269 LYS A HG2  1 
ATOM   4063 H HG3  . LYS A 1 269 ? -21.42168 -0.31706  30.55400  1.000 51.99869 ? 269 LYS A HG3  1 
ATOM   4064 H HD2  . LYS A 1 269 ? -22.89485 -0.54026  32.33306  1.000 52.61617 ? 269 LYS A HD2  1 
ATOM   4065 H HD3  . LYS A 1 269 ? -21.81968 0.08206   33.32410  1.000 52.61617 ? 269 LYS A HD3  1 
ATOM   4066 H HE2  . LYS A 1 269 ? -22.01888 2.14107   32.27553  1.000 60.16922 ? 269 LYS A HE2  1 
ATOM   4067 H HE3  . LYS A 1 269 ? -23.05206 1.52604   31.23646  1.000 60.16922 ? 269 LYS A HE3  1 
ATOM   4068 H HZ1  . LYS A 1 269 ? -24.51863 1.23640   32.94157  1.000 66.47998 ? 269 LYS A HZ1  1 
ATOM   4069 H HZ2  . LYS A 1 269 ? -23.57039 1.72791   33.92013  1.000 66.47998 ? 269 LYS A HZ2  1 
ATOM   4070 H HZ3  . LYS A 1 269 ? -24.12928 2.63164   32.93563  1.000 66.47998 ? 269 LYS A HZ3  1 
ATOM   4071 N N    . GLU A 1 270 ? -17.46713 -0.88305  31.76608  1.000 34.51289 ? 270 GLU A N    1 
ATOM   4072 C CA   . GLU A 1 270 ? -16.40960 0.11756   31.66138  1.000 38.55872 ? 270 GLU A CA   1 
ATOM   4073 C C    . GLU A 1 270 ? -15.35748 -0.29547  30.63889  1.000 36.80550 ? 270 GLU A C    1 
ATOM   4074 O O    . GLU A 1 270 ? -14.82412 0.55141   29.91293  1.000 35.44195 ? 270 GLU A O    1 
ATOM   4075 C CB   . GLU A 1 270 ? -15.77052 0.35192   33.03073  1.000 39.79549 ? 270 GLU A CB   1 
ATOM   4076 C CG   . GLU A 1 270 ? -16.71846 0.95022   34.07010  1.000 44.43918 ? 270 GLU A CG   1 
ATOM   4077 C CD   . GLU A 1 270 ? -17.42540 2.20442   33.57830  1.000 57.41180 ? 270 GLU A CD   1 
ATOM   4078 O OE1  . GLU A 1 270 ? -16.78508 3.01863   32.87760  1.000 52.47112 ? 270 GLU A OE1  1 
ATOM   4079 O OE2  . GLU A 1 270 ? -18.62576 2.37064   33.88586  1.000 56.95285 ? 270 GLU A OE2  1 
ATOM   4080 H H    . GLU A 1 270 ? -17.50337 -1.29293  32.52126  1.000 41.43824 ? 270 GLU A H    1 
ATOM   4081 H HA   . GLU A 1 270 ? -16.79985 0.95539   31.36704  1.000 46.29325 ? 270 GLU A HA   1 
ATOM   4082 H HB2  . GLU A 1 270 ? -15.45472 -0.49810  33.37516  1.000 47.77736 ? 270 GLU A HB2  1 
ATOM   4083 H HB3  . GLU A 1 270 ? -15.02572 0.96423   32.92467  1.000 47.77736 ? 270 GLU A HB3  1 
ATOM   4084 H HG2  . GLU A 1 270 ? -17.39627 0.29328   34.29351  1.000 53.34979 ? 270 GLU A HG2  1 
ATOM   4085 H HG3  . GLU A 1 270 ? -16.21005 1.18487   34.86215  1.000 53.34979 ? 270 GLU A HG3  1 
ATOM   4086 N N    . LEU A 1 271 ? -15.04751 -1.59104  30.56182  1.000 33.93931 ? 271 LEU A N    1 
ATOM   4087 C CA   . LEU A 1 271 ? -14.09230 -2.05386  29.56176  1.000 35.69994 ? 271 LEU A CA   1 
ATOM   4088 C C    . LEU A 1 271 ? -14.63026 -1.86603  28.14972  1.000 32.82855 ? 271 LEU A C    1 
ATOM   4089 O O    . LEU A 1 271 ? -13.85533 -1.61092  27.22114  1.000 33.72226 ? 271 LEU A O    1 
ATOM   4090 C CB   . LEU A 1 271 ? -13.74969 -3.52347  29.80405  1.000 33.19604 ? 271 LEU A CB   1 
ATOM   4091 C CG   . LEU A 1 271 ? -12.93151 -3.85735  31.05300  1.000 33.41581 ? 271 LEU A CG   1 
ATOM   4092 C CD1  . LEU A 1 271 ? -13.03132 -5.34816  31.35304  1.000 30.67040 ? 271 LEU A CD1  1 
ATOM   4093 C CD2  . LEU A 1 271 ? -11.47360 -3.44213  30.88510  1.000 38.11792 ? 271 LEU A CD2  1 
ATOM   4094 H H    . LEU A 1 271 ? -15.37025 -2.20786  31.06676  1.000 40.74995 ? 271 LEU A H    1 
ATOM   4095 H HA   . LEU A 1 271 ? -13.27570 -1.53723  29.64638  1.000 42.86270 ? 271 LEU A HA   1 
ATOM   4096 H HB2  . LEU A 1 271 ? -14.58288 -4.01526  29.87364  1.000 39.85803 ? 271 LEU A HB2  1 
ATOM   4097 H HB3  . LEU A 1 271 ? -13.24059 -3.83956  29.04129  1.000 39.85803 ? 271 LEU A HB3  1 
ATOM   4098 H HG   . LEU A 1 271 ? -13.28901 -3.36167  31.80626  1.000 40.12175 ? 271 LEU A HG   1 
ATOM   4099 H HD11 . LEU A 1 271 ? -12.44973 -5.55959  32.10000  1.000 36.82726 ? 271 LEU A HD11 1 
ATOM   4100 H HD12 . LEU A 1 271 ? -13.94990 -5.56431  31.57753  1.000 36.82726 ? 271 LEU A HD12 1 
ATOM   4101 H HD13 . LEU A 1 271 ? -12.75639 -5.84737  30.56812  1.000 36.82726 ? 271 LEU A HD13 1 
ATOM   4102 H HD21 . LEU A 1 271 ? -10.91520 -4.02548  31.42249  1.000 45.76428 ? 271 LEU A HD21 1 
ATOM   4103 H HD22 . LEU A 1 271 ? -11.22890 -3.51960  29.94967  1.000 45.76428 ? 271 LEU A HD22 1 
ATOM   4104 H HD23 . LEU A 1 271 ? -11.37107 -2.52338  31.17883  1.000 45.76428 ? 271 LEU A HD23 1 
ATOM   4105 N N    . LEU A 1 272 ? -15.94720 -1.98434  27.96648  1.000 31.51263 ? 272 LEU A N    1 
ATOM   4106 C CA   . LEU A 1 272 ? -16.52006 -1.79978  26.63757  1.000 34.02025 ? 272 LEU A CA   1 
ATOM   4107 C C    . LEU A 1 272 ? -16.52969 -0.32969  26.24014  1.000 39.45715 ? 272 LEU A C    1 
ATOM   4108 O O    . LEU A 1 272 ? -16.23462 0.00941   25.08838  1.000 37.65292 ? 272 LEU A O    1 
ATOM   4109 C CB   . LEU A 1 272 ? -17.93693 -2.37313  26.58882  1.000 33.72029 ? 272 LEU A CB   1 
ATOM   4110 C CG   . LEU A 1 272 ? -18.05867 -3.89420  26.46425  1.000 32.73557 ? 272 LEU A CG   1 
ATOM   4111 C CD1  . LEU A 1 272 ? -19.52188 -4.31944  26.51701  1.000 32.53210 ? 272 LEU A CD1  1 
ATOM   4112 C CD2  . LEU A 1 272 ? -17.40864 -4.38083  25.17858  1.000 32.03990 ? 272 LEU A CD2  1 
ATOM   4113 H H    . LEU A 1 272 ? -16.51771 -2.16716  28.58348  1.000 37.83793 ? 272 LEU A H    1 
ATOM   4114 H HA   . LEU A 1 272 ? -15.97690 -2.28429  25.99637  1.000 40.84708 ? 272 LEU A HA   1 
ATOM   4115 H HB2  . LEU A 1 272 ? -18.39207 -2.11746  27.40636  1.000 40.48713 ? 272 LEU A HB2  1 
ATOM   4116 H HB3  . LEU A 1 272 ? -18.39000 -1.98792  25.82250  1.000 40.48713 ? 272 LEU A HB3  1 
ATOM   4117 H HG   . LEU A 1 272 ? -17.59635 -4.30822  27.20974  1.000 39.30547 ? 272 LEU A HG   1 
ATOM   4118 H HD11 . LEU A 1 272 ? -20.01762 -3.82966  25.84229  1.000 39.06130 ? 272 LEU A HD11 1 
ATOM   4119 H HD12 . LEU A 1 272 ? -19.58033 -5.27209  26.34396  1.000 39.06130 ? 272 LEU A HD12 1 
ATOM   4120 H HD13 . LEU A 1 272 ? -19.87692 -4.12082  27.39758  1.000 39.06130 ? 272 LEU A HD13 1 
ATOM   4121 H HD21 . LEU A 1 272 ? -16.44455 -4.35075  25.28112  1.000 38.47066 ? 272 LEU A HD21 1 
ATOM   4122 H HD22 . LEU A 1 272 ? -17.69459 -5.29136  25.00513  1.000 38.47066 ? 272 LEU A HD22 1 
ATOM   4123 H HD23 . LEU A 1 272 ? -17.68181 -3.80358  24.44846  1.000 38.47066 ? 272 LEU A HD23 1 
ATOM   4124 N N    . GLN A 1 273 ? -16.86530 0.55670   27.17801  1.000 37.79601 ? 273 GLN A N    1 
ATOM   4125 C CA   . GLN A 1 273 ? -16.95643 1.97797   26.87230  1.000 40.14657 ? 273 GLN A CA   1 
ATOM   4126 C C    . GLN A 1 273 ? -15.60058 2.67301   26.84622  1.000 38.89479 ? 273 GLN A C    1 
ATOM   4127 O O    . GLN A 1 273 ? -15.46972 3.71178   26.19038  1.000 42.40211 ? 273 GLN A O    1 
ATOM   4128 C CB   . GLN A 1 273 ? -17.86241 2.67296   27.89214  1.000 43.47420 ? 273 GLN A CB   1 
ATOM   4129 C CG   . GLN A 1 273 ? -19.33033 2.27903   27.79918  1.000 41.48333 ? 273 GLN A CG   1 
ATOM   4130 C CD   . GLN A 1 273 ? -20.15503 2.82769   28.94918  1.000 49.47597 ? 273 GLN A CD   1 
ATOM   4131 O OE1  . GLN A 1 273 ? -19.61225 3.33177   29.93306  1.000 49.54972 ? 273 GLN A OE1  1 
ATOM   4132 N NE2  . GLN A 1 273 ? -21.47434 2.73322   28.82975  1.000 54.98239 ? 273 GLN A NE2  1 
ATOM   4133 H H    . GLN A 1 273 ? -17.04400 0.35844   27.99554  1.000 45.37800 ? 273 GLN A H    1 
ATOM   4134 H HA   . GLN A 1 273 ? -17.35315 2.07605   25.99259  1.000 48.19867 ? 273 GLN A HA   1 
ATOM   4135 H HB2  . GLN A 1 273 ? -17.55400 2.44813   28.78390  1.000 52.19182 ? 273 GLN A HB2  1 
ATOM   4136 H HB3  . GLN A 1 273 ? -17.80627 3.63135   27.75348  1.000 52.19182 ? 273 GLN A HB3  1 
ATOM   4137 H HG2  . GLN A 1 273 ? -19.69962 2.62592   26.97203  1.000 49.80277 ? 273 GLN A HG2  1 
ATOM   4138 H HG3  . GLN A 1 273 ? -19.40024 1.31166   27.81375  1.000 49.80277 ? 273 GLN A HG3  1 
ATOM   4139 H HE21 . GLN A 1 273 ? -21.81798 2.37544   28.12725  1.000 66.00165 ? 273 GLN A HE21 1 
ATOM   4140 H HE22 . GLN A 1 273 ? -21.98502 3.02982   29.45491  1.000 66.00165 ? 273 GLN A HE22 1 
ATOM   4141 N N    . ASN A 1 274 ? -14.59287 2.12898   27.52962  1.000 41.40439 ? 274 ASN A N    1 
ATOM   4142 C CA   . ASN A 1 274 ? -13.31453 2.80606   27.69367  1.000 39.57434 ? 274 ASN A CA   1 
ATOM   4143 C C    . ASN A 1 274 ? -12.12916 2.02843   27.13832  1.000 40.31697 ? 274 ASN A C    1 
ATOM   4144 O O    . ASN A 1 274 ? -10.99761 2.51948   27.22248  1.000 42.04883 ? 274 ASN A O    1 
ATOM   4145 C CB   . ASN A 1 274 ? -13.06716 3.10493   29.18075  1.000 43.63301 ? 274 ASN A CB   1 
ATOM   4146 C CG   . ASN A 1 274 ? -14.22865 3.83433   29.83242  1.000 46.01888 ? 274 ASN A CG   1 
ATOM   4147 O OD1  . ASN A 1 274 ? -14.73184 3.41423   30.87254  1.000 46.40415 ? 274 ASN A OD1  1 
ATOM   4148 N ND2  . ASN A 1 274 ? -14.65898 4.93430   29.22229  1.000 50.08027 ? 274 ASN A ND2  1 
ATOM   4149 H H    . ASN A 1 274 ? -14.62943 1.35895   27.91085  1.000 49.70805 ? 274 ASN A H    1 
ATOM   4150 H HA   . ASN A 1 274 ? -13.35632 3.64771   27.21327  1.000 47.51198 ? 274 ASN A HA   1 
ATOM   4151 H HB2  . ASN A 1 274 ? -12.93446 2.26854   29.65376  1.000 52.38239 ? 274 ASN A HB2  1 
ATOM   4152 H HB3  . ASN A 1 274 ? -12.27767 3.66226   29.26441  1.000 52.38239 ? 274 ASN A HB3  1 
ATOM   4153 H HD21 . ASN A 1 274 ? -15.31458 5.38140   29.55380  1.000 60.11910 ? 274 ASN A HD21 1 
ATOM   4154 H HD22 . ASN A 1 274 ? -14.28177 5.19877   28.49609  1.000 60.11910 ? 274 ASN A HD22 1 
ATOM   4155 N N    . GLY A 1 275 ? -12.33723 0.84546   26.56791  1.000 43.31862 ? 275 GLY A N    1 
ATOM   4156 C CA   . GLY A 1 275 ? -11.18389 0.07250   26.15383  1.000 40.00831 ? 275 GLY A CA   1 
ATOM   4157 C C    . GLY A 1 275 ? -10.31433 -0.32058  27.33005  1.000 41.96067 ? 275 GLY A C    1 
ATOM   4158 O O    . GLY A 1 275 ? -10.62035 -0.05416  28.49548  1.000 40.41247 ? 275 GLY A O    1 
ATOM   4159 H H    . GLY A 1 275 ? -13.10508 0.48822   26.41827  1.000 52.00512 ? 275 GLY A H    1 
ATOM   4160 H HA2  . GLY A 1 275 ? -11.48066 -0.73559  25.70681  1.000 48.03275 ? 275 GLY A HA2  1 
ATOM   4161 H HA3  . GLY A 1 275 ? -10.64898 0.59631   25.53707  1.000 48.03275 ? 275 GLY A HA3  1 
ATOM   4162 N N    . MET A 1 276 ? -9.19775  -0.96129  26.99484  1.000 42.92496 ? 276 MET A N    1 
ATOM   4163 C CA   . MET A 1 276 ? -8.27915  -1.48870  27.98705  1.000 43.32004 ? 276 MET A CA   1 
ATOM   4164 C C    . MET A 1 276 ? -7.06599  -0.59619  28.21398  1.000 45.25853 ? 276 MET A C    1 
ATOM   4165 O O    . MET A 1 276 ? -6.23166  -0.93186  29.05414  1.000 46.31655 ? 276 MET A O    1 
ATOM   4166 C CB   . MET A 1 276 ? -7.80878  -2.89522  27.58567  1.000 44.97338 ? 276 MET A CB   1 
ATOM   4167 C CG   . MET A 1 276 ? -8.90417  -3.81777  27.04423  1.000 44.10538 ? 276 MET A CG   1 
ATOM   4168 S SD   . MET A 1 276 ? -8.99405  -5.42498  27.86335  1.000 49.89939 ? 276 MET A SD   1 
ATOM   4169 C CE   . MET A 1 276 ? -7.26988  -5.89790  27.96680  1.000 35.75789 ? 276 MET A CE   1 
ATOM   4170 H H    . MET A 1 276 ? -8.95004  -1.10324  26.18362  1.000 51.53273 ? 276 MET A H    1 
ATOM   4171 H HA   . MET A 1 276 ? -8.76176  -1.56772  28.82475  1.000 52.00682 ? 276 MET A HA   1 
ATOM   4172 H HB2  . MET A 1 276 ? -7.13519  -2.80706  26.89328  1.000 53.99084 ? 276 MET A HB2  1 
ATOM   4173 H HB3  . MET A 1 276 ? -7.42718  -3.32524  28.36693  1.000 53.99084 ? 276 MET A HB3  1 
ATOM   4174 H HG2  . MET A 1 276 ? -9.76258  -3.38110  27.15986  1.000 52.94923 ? 276 MET A HG2  1 
ATOM   4175 H HG3  . MET A 1 276 ? -8.73745  -3.97751  26.10211  1.000 52.94923 ? 276 MET A HG3  1 
ATOM   4176 H HE1  . MET A 1 276 ? -6.79588  -5.53267  27.20337  1.000 42.93224 ? 276 MET A HE1  1 
ATOM   4177 H HE2  . MET A 1 276 ? -6.89449  -5.54536  28.78881  1.000 42.93224 ? 276 MET A HE2  1 
ATOM   4178 H HE3  . MET A 1 276 ? -7.20714  -6.86586  27.96296  1.000 42.93224 ? 276 MET A HE3  1 
ATOM   4179 N N    . ASN A 1 277 ? -6.93882  0.52418   27.49795  1.000 44.49454 ? 277 ASN A N    1 
ATOM   4180 C CA   . ASN A 1 277 ? -5.84326  1.47348   27.72984  1.000 46.61315 ? 277 ASN A CA   1 
ATOM   4181 C C    . ASN A 1 277 ? -4.47780  0.81175   27.55560  1.000 45.12873 ? 277 ASN A C    1 
ATOM   4182 O O    . ASN A 1 277 ? -3.51926  1.12638   28.26649  1.000 45.60649 ? 277 ASN A O    1 
ATOM   4183 C CB   . ASN A 1 277 ? -5.94975  2.10329   29.12031  1.000 46.88685 ? 277 ASN A CB   1 
ATOM   4184 C CG   . ASN A 1 277 ? -7.08160  3.10249   29.22239  1.000 50.95274 ? 277 ASN A CG   1 
ATOM   4185 O OD1  . ASN A 1 277 ? -7.16178  4.04722   28.43808  1.000 49.71934 ? 277 ASN A OD1  1 
ATOM   4186 N ND2  . ASN A 1 277 ? -7.96974  2.89632   30.18993  1.000 53.75278 ? 277 ASN A ND2  1 
ATOM   4187 H H    . ASN A 1 277 ? -7.47632  0.75894   26.86899  1.000 53.41622 ? 277 ASN A H    1 
ATOM   4188 H HA   . ASN A 1 277 ? -5.91334  2.17644   27.06514  1.000 55.95856 ? 277 ASN A HA   1 
ATOM   4189 H HB2  . ASN A 1 277 ? -6.10692  1.40361   29.77349  1.000 56.28700 ? 277 ASN A HB2  1 
ATOM   4190 H HB3  . ASN A 1 277 ? -5.12151  2.56592   29.32250  1.000 56.28700 ? 277 ASN A HB3  1 
ATOM   4191 H HD21 . ASN A 1 277 ? -8.63135  3.43682   30.28864  1.000 64.52611 ? 277 ASN A HD21 1 
ATOM   4192 H HD22 . ASN A 1 277 ? -7.88267  2.22245   30.71711  1.000 64.52611 ? 277 ASN A HD22 1 
ATOM   4193 N N    . GLY A 1 278 ? -4.38459  -0.11466  26.60517  1.000 45.23474 ? 278 GLY A N    1 
ATOM   4194 C CA   . GLY A 1 278 ? -3.14707  -0.84086  26.41373  1.000 43.10945 ? 278 GLY A CA   1 
ATOM   4195 C C    . GLY A 1 278 ? -2.76827  -1.76704  27.54666  1.000 40.54724 ? 278 GLY A C    1 
ATOM   4196 O O    . GLY A 1 278 ? -1.63817  -2.26396  27.56700  1.000 39.85001 ? 278 GLY A O    1 
ATOM   4197 H H    . GLY A 1 278 ? -5.01899  -0.33433  26.06769  1.000 54.30446 ? 278 GLY A H    1 
ATOM   4198 H HA2  . GLY A 1 278 ? -3.22285  -1.37557  25.60798  1.000 51.75412 ? 278 GLY A HA2  1 
ATOM   4199 H HA3  . GLY A 1 278 ? -2.42645  -0.20129  26.30170  1.000 51.75412 ? 278 GLY A HA3  1 
ATOM   4200 N N    . ARG A 1 279 ? -3.67197  -2.00798  28.49590  1.000 41.66804 ? 279 ARG A N    1 
ATOM   4201 C CA   . ARG A 1 279 ? -3.47627  -3.02208  29.52066  1.000 38.74660 ? 279 ARG A CA   1 
ATOM   4202 C C    . ARG A 1 279 ? -3.86797  -4.38300  28.94918  1.000 36.85277 ? 279 ARG A C    1 
ATOM   4203 O O    . ARG A 1 279 ? -4.32727  -4.49174  27.81056  1.000 34.13252 ? 279 ARG A O    1 
ATOM   4204 C CB   . ARG A 1 279 ? -4.28258  -2.68855  30.77772  1.000 40.31288 ? 279 ARG A CB   1 
ATOM   4205 C CG   . ARG A 1 279 ? -3.61493  -1.66835  31.68467  1.000 42.55658 ? 279 ARG A CG   1 
ATOM   4206 C CD   . ARG A 1 279 ? -4.08714  -0.24813  31.43189  1.000 48.67092 ? 279 ARG A CD   1 
ATOM   4207 N NE   . ARG A 1 279 ? -5.39093  0.01946   32.03124  1.000 53.20058 ? 279 ARG A NE   1 
ATOM   4208 C CZ   . ARG A 1 279 ? -5.75688  1.18104   32.56312  1.000 58.23497 ? 279 ARG A CZ   1 
ATOM   4209 N NH1  . ARG A 1 279 ? -4.93398  2.21999   32.60591  1.000 54.05112 ? 279 ARG A NH1  1 
ATOM   4210 N NH2  . ARG A 1 279 ? -6.97689  1.30094   33.07917  1.000 58.49207 ? 279 ARG A NH2  1 
ATOM   4211 H H    . ARG A 1 279 ? -4.41918  -1.58809  28.56642  1.000 50.02442 ? 279 ARG A H    1 
ATOM   4212 H HA   . ARG A 1 279 ? -2.54137  -3.04256  29.77843  1.000 46.51869 ? 279 ARG A HA   1 
ATOM   4213 H HB2  . ARG A 1 279 ? -5.14214  -2.32782  30.50953  1.000 48.39824 ? 279 ARG A HB2  1 
ATOM   4214 H HB3  . ARG A 1 279 ? -4.40961  -3.50183  31.29089  1.000 48.39824 ? 279 ARG A HB3  1 
ATOM   4215 H HG2  . ARG A 1 279 ? -3.81447  -1.88900  32.60793  1.000 51.09067 ? 279 ARG A HG2  1 
ATOM   4216 H HG3  . ARG A 1 279 ? -2.65660  -1.69464  31.53695  1.000 51.09067 ? 279 ARG A HG3  1 
ATOM   4217 H HD2  . ARG A 1 279 ? -3.44685  0.37228   31.81401  1.000 58.42788 ? 279 ARG A HD2  1 
ATOM   4218 H HD3  . ARG A 1 279 ? -4.15967  -0.10295  30.47556  1.000 58.42788 ? 279 ARG A HD3  1 
ATOM   4219 H HE   . ARG A 1 279 ? -5.96423  -0.62151  32.04087  1.000 63.86348 ? 279 ARG A HE   1 
ATOM   4220 H HH11 . ARG A 1 279 ? -4.13936  2.15269   32.28398  1.000 64.88412 ? 279 ARG A HH11 1 
ATOM   4221 H HH12 . ARG A 1 279 ? -5.19492  2.96109   32.95559  1.000 64.88412 ? 279 ARG A HH12 1 
ATOM   4222 H HH21 . ARG A 1 279 ? -7.51711  0.63192   33.06577  1.000 70.21326 ? 279 ARG A HH21 1 
ATOM   4223 H HH22 . ARG A 1 279 ? -7.22551  2.04748   33.42624  1.000 70.21326 ? 279 ARG A HH22 1 
ATOM   4224 N N    . THR A 1 280 ? -3.68364  -5.44051  29.73861  1.000 35.94466 ? 280 THR A N    1 
ATOM   4225 C CA   . THR A 1 280 ? -3.93910  -6.79685  29.27333  1.000 32.62220 ? 280 THR A CA   1 
ATOM   4226 C C    . THR A 1 280 ? -4.59569  -7.61024  30.37826  1.000 33.97962 ? 280 THR A C    1 
ATOM   4227 O O    . THR A 1 280 ? -4.34067  -7.39825  31.56662  1.000 33.14821 ? 280 THR A O    1 
ATOM   4228 C CB   . THR A 1 280 ? -2.64704  -7.49130  28.81916  1.000 32.80740 ? 280 THR A CB   1 
ATOM   4229 O OG1  . THR A 1 280 ? -1.78848  -7.69024  29.94797  1.000 35.19300 ? 280 THR A OG1  1 
ATOM   4230 C CG2  . THR A 1 280 ? -1.93007  -6.64952  27.76922  1.000 33.98976 ? 280 THR A CG2  1 
ATOM   4231 H H    . THR A 1 280 ? -3.40937  -5.39484  30.55243  1.000 43.15637 ? 280 THR A H    1 
ATOM   4232 H HA   . THR A 1 280 ? -4.55290  -6.76233  28.52302  1.000 39.16941 ? 280 THR A HA   1 
ATOM   4233 H HB   . THR A 1 280 ? -2.85949  -8.35118  28.42372  1.000 39.39165 ? 280 THR A HB   1 
ATOM   4234 H HG1  . THR A 1 280 ? -2.05980  -8.34136  30.40407  1.000 42.25437 ? 280 THR A HG1  1 
ATOM   4235 H HG21 . THR A 1 280 ? -2.54719  -6.40526  27.06183  1.000 40.81049 ? 280 THR A HG21 1 
ATOM   4236 H HG22 . THR A 1 280 ? -1.58006  -5.84086  28.17476  1.000 40.81049 ? 280 THR A HG22 1 
ATOM   4237 H HG23 . THR A 1 280 ? -1.19497  -7.15298  27.38575  1.000 40.81049 ? 280 THR A HG23 1 
ATOM   4238 N N    . ILE A 1 281 ? -5.44545  -8.54626  29.96282  1.000 33.96411 ? 281 ILE A N    1 
ATOM   4239 C CA   . ILE A 1 281 ? -6.13387  -9.47058  30.85460  1.000 31.49471 ? 281 ILE A CA   1 
ATOM   4240 C C    . ILE A 1 281 ? -5.78447  -10.88421 30.41463  1.000 35.95085 ? 281 ILE A C    1 
ATOM   4241 O O    . ILE A 1 281 ? -5.99807  -11.24600 29.24927  1.000 32.21096 ? 281 ILE A O    1 
ATOM   4242 C CB   . ILE A 1 281 ? -7.65489  -9.24618  30.83685  1.000 32.25136 ? 281 ILE A CB   1 
ATOM   4243 C CG1  . ILE A 1 281 ? -7.99667  -7.86513  31.40945  1.000 37.12407 ? 281 ILE A CG1  1 
ATOM   4244 C CG2  . ILE A 1 281 ? -8.35869  -10.33333 31.62601  1.000 35.38233 ? 281 ILE A CG2  1 
ATOM   4245 C CD1  . ILE A 1 281 ? -9.37760  -7.37872  31.04448  1.000 33.30453 ? 281 ILE A CD1  1 
ATOM   4246 H H    . ILE A 1 281 ? -5.64594  -8.66854  29.13550  1.000 40.77971 ? 281 ILE A H    1 
ATOM   4247 H HA   . ILE A 1 281 ? -5.81693  -9.34622  31.76289  1.000 37.81643 ? 281 ILE A HA   1 
ATOM   4248 H HB   . ILE A 1 281 ? -7.95900  -9.28400  29.91653  1.000 38.72440 ? 281 ILE A HB   1 
ATOM   4249 H HG12 . ILE A 1 281 ? -7.94409  -7.90728  32.37711  1.000 44.57166 ? 281 ILE A HG12 1 
ATOM   4250 H HG13 . ILE A 1 281 ? -7.35661  -7.22004  31.07022  1.000 44.57166 ? 281 ILE A HG13 1 
ATOM   4251 H HG21 . ILE A 1 281 ? -7.86386  -10.50095 32.44329  1.000 42.48157 ? 281 ILE A HG21 1 
ATOM   4252 H HG22 . ILE A 1 281 ? -9.25777  -10.03763 31.83842  1.000 42.48157 ? 281 ILE A HG22 1 
ATOM   4253 H HG23 . ILE A 1 281 ? -8.39410  -11.14054 31.08931  1.000 42.48157 ? 281 ILE A HG23 1 
ATOM   4254 H HD11 . ILE A 1 281 ? -10.02863 -7.82321  31.60972  1.000 39.98821 ? 281 ILE A HD11 1 
ATOM   4255 H HD12 . ILE A 1 281 ? -9.42093  -6.41939  31.18132  1.000 39.98821 ? 281 ILE A HD12 1 
ATOM   4256 H HD13 . ILE A 1 281 ? -9.55031  -7.58813  30.11323  1.000 39.98821 ? 281 ILE A HD13 1 
ATOM   4257 N N    . LEU A 1 282 ? -5.25798  -11.67713 31.34767  1.000 32.41102 ? 282 LEU A N    1 
ATOM   4258 C CA   . LEU A 1 282 ? -4.71892  -13.00492 31.05802  1.000 35.27532 ? 282 LEU A CA   1 
ATOM   4259 C C    . LEU A 1 282 ? -3.94072  -12.99741 29.74618  1.000 33.40881 ? 282 LEU A C    1 
ATOM   4260 O O    . LEU A 1 282 ? -4.14785  -13.82612 28.85601  1.000 33.87228 ? 282 LEU A O    1 
ATOM   4261 C CB   . LEU A 1 282 ? -5.82992  -14.05422 31.04186  1.000 35.23144 ? 282 LEU A CB   1 
ATOM   4262 C CG   . LEU A 1 282 ? -6.47997  -14.27621 32.41069  1.000 34.63909 ? 282 LEU A CG   1 
ATOM   4263 C CD1  . LEU A 1 282 ? -7.80185  -15.00443 32.27723  1.000 34.64045 ? 282 LEU A CD1  1 
ATOM   4264 C CD2  . LEU A 1 282 ? -5.53378  -15.04594 33.33258  1.000 36.09000 ? 282 LEU A CD2  1 
ATOM   4265 H H    . LEU A 1 282 ? -5.20029  -11.46212 32.17836  1.000 38.91600 ? 282 LEU A H    1 
ATOM   4266 H HA   . LEU A 1 282 ? -4.09847  -13.24567 31.76370  1.000 42.35316 ? 282 LEU A HA   1 
ATOM   4267 H HB2  . LEU A 1 282 ? -6.52225  -13.76639 30.42644  1.000 42.30051 ? 282 LEU A HB2  1 
ATOM   4268 H HB3  . LEU A 1 282 ? -5.45626  -14.90003 30.74882  1.000 42.30051 ? 282 LEU A HB3  1 
ATOM   4269 H HG   . LEU A 1 282 ? -6.66077  -13.41148 32.81124  1.000 41.58968 ? 282 LEU A HG   1 
ATOM   4270 H HD11 . LEU A 1 282 ? -8.34535  -14.55306 31.61257  1.000 41.59132 ? 282 LEU A HD11 1 
ATOM   4271 H HD12 . LEU A 1 282 ? -7.63230  -15.91854 32.00055  1.000 41.59132 ? 282 LEU A HD12 1 
ATOM   4272 H HD13 . LEU A 1 282 ? -8.25449  -14.99704 33.13511  1.000 41.59132 ? 282 LEU A HD13 1 
ATOM   4273 H HD21 . LEU A 1 282 ? -5.22751  -15.84460 32.87515  1.000 43.33078 ? 282 LEU A HD21 1 
ATOM   4274 H HD22 . LEU A 1 282 ? -4.77728  -14.48001 33.55241  1.000 43.33078 ? 282 LEU A HD22 1 
ATOM   4275 H HD23 . LEU A 1 282 ? -6.01024  -15.29018 34.14142  1.000 43.33078 ? 282 LEU A HD23 1 
ATOM   4276 N N    . GLY A 1 283 ? -3.03830  -12.02383 29.63529  1.000 30.86959 ? 283 GLY A N    1 
ATOM   4277 C CA   . GLY A 1 283 ? -2.14682  -11.93627 28.49920  1.000 33.56555 ? 283 GLY A CA   1 
ATOM   4278 C C    . GLY A 1 283 ? -2.80904  -11.62495 27.18017  1.000 34.32775 ? 283 GLY A C    1 
ATOM   4279 O O    . GLY A 1 283 ? -2.20490  -11.85240 26.13087  1.000 33.87686 ? 283 GLY A O    1 
ATOM   4280 H H    . GLY A 1 283 ? -2.92605  -11.39791 30.21428  1.000 37.06629 ? 283 GLY A H    1 
ATOM   4281 H HA2  . GLY A 1 283 ? -1.49452  -11.23941 28.67180  1.000 40.30143 ? 283 GLY A HA2  1 
ATOM   4282 H HA3  . GLY A 1 283 ? -1.68533  -12.78401 28.40303  1.000 40.30143 ? 283 GLY A HA3  1 
ATOM   4283 N N    . SER A 1 284 ? -4.03788  -11.12207 27.19453  1.000 30.61199 ? 284 SER A N    1 
ATOM   4284 C CA   . SER A 1 284 ? -4.73354  -10.72173 25.98127  1.000 31.38629 ? 284 SER A CA   1 
ATOM   4285 C C    . SER A 1 284 ? -5.13607  -9.25794  26.07817  1.000 30.85146 ? 284 SER A C    1 
ATOM   4286 O O    . SER A 1 284 ? -5.49871  -8.77339  27.15451  1.000 30.84549 ? 284 SER A O    1 
ATOM   4287 C CB   . SER A 1 284 ? -5.97905  -11.57806 25.74057  1.000 31.84761 ? 284 SER A CB   1 
ATOM   4288 O OG   . SER A 1 284 ? -6.75555  -11.04046 24.68276  1.000 32.03202 ? 284 SER A OG   1 
ATOM   4289 H H    . SER A 1 284 ? -4.49760  -11.00131 27.91125  1.000 36.75716 ? 284 SER A H    1 
ATOM   4290 H HA   . SER A 1 284 ? -4.13744  -10.82998 25.22374  1.000 37.68632 ? 284 SER A HA   1 
ATOM   4291 H HB2  . SER A 1 284 ? -5.70431  -12.47836 25.50628  1.000 38.23991 ? 284 SER A HB2  1 
ATOM   4292 H HB3  . SER A 1 284 ? -6.51374  -11.59436 26.54973  1.000 38.23991 ? 284 SER A HB3  1 
ATOM   4293 H HG   . SER A 1 284 ? -7.57131  -11.18207 24.82447  1.000 38.46120 ? 284 SER A HG   1 
ATOM   4294 N N    . ALA A 1 285 ? -5.06720  -8.55612  24.94932  1.000 30.20889 ? 285 ALA A N    1 
ATOM   4295 C CA   . ALA A 1 285 ? -5.49106  -7.16653  24.86855  1.000 33.25271 ? 285 ALA A CA   1 
ATOM   4296 C C    . ALA A 1 285 ? -6.88232  -7.02036  24.26681  1.000 32.98095 ? 285 ALA A C    1 
ATOM   4297 O O    . ALA A 1 285 ? -7.30725  -5.89856  23.97241  1.000 28.68459 ? 285 ALA A O    1 
ATOM   4298 C CB   . ALA A 1 285 ? -4.47786  -6.35554  24.06418  1.000 32.84363 ? 285 ALA A CB   1 
ATOM   4299 H H    . ALA A 1 285 ? -4.77281  -8.87134  24.20529  1.000 36.27345 ? 285 ALA A H    1 
ATOM   4300 H HA   . ALA A 1 285 ? -5.51753  -6.79559  25.76443  1.000 39.92603 ? 285 ALA A HA   1 
ATOM   4301 H HB1  . ALA A 1 285 ? -3.61573  -6.39927  24.50658  1.000 39.43513 ? 285 ALA A HB1  1 
ATOM   4302 H HB2  . ALA A 1 285 ? -4.41103  -6.72964  23.17172  1.000 39.43513 ? 285 ALA A HB2  1 
ATOM   4303 H HB3  . ALA A 1 285 ? -4.77813  -5.43449  24.01512  1.000 39.43513 ? 285 ALA A HB3  1 
ATOM   4304 N N    . LEU A 1 286 ? -7.59234  -8.12826  24.07239  1.000 26.91225 ? 286 LEU A N    1 
ATOM   4305 C CA   . LEU A 1 286 ? -8.98689  -8.12802  23.66405  1.000 29.29607 ? 286 LEU A CA   1 
ATOM   4306 C C    . LEU A 1 286 ? -9.81542  -8.83901  24.72453  1.000 30.56570 ? 286 LEU A C    1 
ATOM   4307 O O    . LEU A 1 286 ? -9.29156  -9.58921  25.55286  1.000 28.57969 ? 286 LEU A O    1 
ATOM   4308 C CB   . LEU A 1 286 ? -9.19397  -8.83124  22.31457  1.000 31.62062 ? 286 LEU A CB   1 
ATOM   4309 C CG   . LEU A 1 286 ? -8.48960  -8.26582  21.08240  1.000 33.74730 ? 286 LEU A CG   1 
ATOM   4310 C CD1  . LEU A 1 286 ? -8.82523  -9.11085  19.86446  1.000 29.61773 ? 286 LEU A CD1  1 
ATOM   4311 C CD2  . LEU A 1 286 ? -8.87164  -6.81263  20.84951  1.000 33.24518 ? 286 LEU A CD2  1 
ATOM   4312 H H    . LEU A 1 286 ? -7.27294  -8.92006  24.17555  1.000 32.31748 ? 286 LEU A H    1 
ATOM   4313 H HA   . LEU A 1 286 ? -9.28936  -7.21090  23.57289  1.000 35.17806 ? 286 LEU A HA   1 
ATOM   4314 H HB2  . LEU A 1 286 ? -8.88841  -9.74670  22.41182  1.000 37.96752 ? 286 LEU A HB2  1 
ATOM   4315 H HB3  . LEU A 1 286 ? -10.14422 -8.81752  22.12032  1.000 37.96752 ? 286 LEU A HB3  1 
ATOM   4316 H HG   . LEU A 1 286 ? -7.53056  -8.29230  21.22533  1.000 40.51954 ? 286 LEU A HG   1 
ATOM   4317 H HD11 . LEU A 1 286 ? -8.23122  -8.86694  19.13744  1.000 35.56406 ? 286 LEU A HD11 1 
ATOM   4318 H HD12 . LEU A 1 286 ? -8.70752  -10.04744 20.08774  1.000 35.56406 ? 286 LEU A HD12 1 
ATOM   4319 H HD13 . LEU A 1 286 ? -9.74616  -8.94491  19.60901  1.000 35.56406 ? 286 LEU A HD13 1 
ATOM   4320 H HD21 . LEU A 1 286 ? -8.58862  -6.55042  19.95955  1.000 39.91700 ? 286 LEU A HD21 1 
ATOM   4321 H HD22 . LEU A 1 286 ? -9.83400  -6.72220  20.93064  1.000 39.91700 ? 286 LEU A HD22 1 
ATOM   4322 H HD23 . LEU A 1 286 ? -8.43034  -6.25982  21.51325  1.000 39.91700 ? 286 LEU A HD23 1 
ATOM   4323 N N    . LEU A 1 287 ? -11.12154 -8.59644  24.68846  1.000 29.54625 ? 287 LEU A N    1 
ATOM   4324 C CA   . LEU A 1 287 ? -12.05666 -9.33484  25.52636  1.000 30.02169 ? 287 LEU A CA   1 
ATOM   4325 C C    . LEU A 1 287 ? -12.33600 -10.68599 24.87415  1.000 29.04627 ? 287 LEU A C    1 
ATOM   4326 O O    . LEU A 1 287 ? -12.80224 -10.74639 23.73240  1.000 30.61794 ? 287 LEU A O    1 
ATOM   4327 C CB   . LEU A 1 287 ? -13.33847 -8.52867  25.72245  1.000 27.31107 ? 287 LEU A CB   1 
ATOM   4328 C CG   . LEU A 1 287 ? -13.14577 -7.19354  26.45480  1.000 29.95163 ? 287 LEU A CG   1 
ATOM   4329 C CD1  . LEU A 1 287 ? -14.42276 -6.36439  26.44245  1.000 34.24319 ? 287 LEU A CD1  1 
ATOM   4330 C CD2  . LEU A 1 287 ? -12.67450 -7.41815  27.89247  1.000 33.22000 ? 287 LEU A CD2  1 
ATOM   4331 H H    . LEU A 1 287 ? -11.49197 -8.00622  24.18444  1.000 35.47827 ? 287 LEU A H    1 
ATOM   4332 H HA   . LEU A 1 287 ? -11.67404 -9.49196  26.40375  1.000 36.04880 ? 287 LEU A HA   1 
ATOM   4333 H HB2  . LEU A 1 287 ? -13.71608 -8.33335  24.85058  1.000 32.79606 ? 287 LEU A HB2  1 
ATOM   4334 H HB3  . LEU A 1 287 ? -13.96100 -9.06117  26.24188  1.000 32.79606 ? 287 LEU A HB3  1 
ATOM   4335 H HG   . LEU A 1 287 ? -12.46049 -6.69215  25.98586  1.000 35.96473 ? 287 LEU A HG   1 
ATOM   4336 H HD11 . LEU A 1 287 ? -14.42904 -5.80597  25.64934  1.000 41.11460 ? 287 LEU A HD11 1 
ATOM   4337 H HD12 . LEU A 1 287 ? -15.18701 -6.96165  26.43253  1.000 41.11460 ? 287 LEU A HD12 1 
ATOM   4338 H HD13 . LEU A 1 287 ? -14.44679 -5.80964  27.23779  1.000 41.11460 ? 287 LEU A HD13 1 
ATOM   4339 H HD21 . LEU A 1 287 ? -11.82268 -7.88190  27.87676  1.000 39.88677 ? 287 LEU A HD21 1 
ATOM   4340 H HD22 . LEU A 1 287 ? -12.57495 -6.55826  28.33016  1.000 39.88677 ? 287 LEU A HD22 1 
ATOM   4341 H HD23 . LEU A 1 287 ? -13.33395 -7.95343  28.36099  1.000 39.88677 ? 287 LEU A HD23 1 
ATOM   4342 N N    . GLU A 1 288 ? -12.02816 -11.76146 25.59542  1.000 30.14036 ? 288 GLU A N    1 
ATOM   4343 C CA   A GLU A 1 288 ? -12.13389 -13.12028 25.08225  0.500 32.06891 ? 288 GLU A CA   1 
ATOM   4344 C CA   B GLU A 1 288 ? -12.13255 -13.12168 25.08025  0.500 31.90289 ? 288 GLU A CA   1 
ATOM   4345 C C    . GLU A 1 288 ? -13.47996 -13.72649 25.45581  1.000 29.17758 ? 288 GLU A C    1 
ATOM   4346 O O    . GLU A 1 288 ? -13.93011 -13.60585 26.59945  1.000 25.87174 ? 288 GLU A O    1 
ATOM   4347 C CB   A GLU A 1 288 ? -10.99855 -13.97079 25.65041  0.500 31.13682 ? 288 GLU A CB   1 
ATOM   4348 C CB   B GLU A 1 288 ? -10.99545 -13.98888 25.62870  0.500 31.24069 ? 288 GLU A CB   1 
ATOM   4349 C CG   A GLU A 1 288 ? -11.06880 -15.45941 25.32969  0.500 33.98092 ? 288 GLU A CG   1 
ATOM   4350 C CG   B GLU A 1 288 ? -9.61136  -13.46534 25.29307  0.500 31.75055 ? 288 GLU A CG   1 
ATOM   4351 C CD   A GLU A 1 288 ? -10.74733 -15.76621 23.87920  0.500 34.41955 ? 288 GLU A CD   1 
ATOM   4352 C CD   B GLU A 1 288 ? -9.33740  -13.45117 23.80068  0.500 35.32840 ? 288 GLU A CD   1 
ATOM   4353 O OE1  A GLU A 1 288 ? -9.71267  -15.27108 23.38517  0.500 34.54719 ? 288 GLU A OE1  1 
ATOM   4354 O OE1  B GLU A 1 288 ? -9.84597  -14.34731 23.09294  0.500 38.07731 ? 288 GLU A OE1  1 
ATOM   4355 O OE2  A GLU A 1 288 ? -11.53074 -16.49429 23.23279  0.500 31.44912 ? 288 GLU A OE2  1 
ATOM   4356 O OE2  B GLU A 1 288 ? -8.61787  -12.54243 23.33281  0.500 32.46484 ? 288 GLU A OE2  1 
ATOM   4357 H H    . GLU A 1 288 ? -11.74799 -11.72563 26.40772  1.000 36.19121 ? 288 GLU A H    1 
ATOM   4358 H HA   . GLU A 1 288 ? -12.07018 -13.11597 24.11435  1.000 38.30625 ? 288 GLU A HA   1 
ATOM   4359 H HB2  A GLU A 1 288 ? -10.16026 -13.63798 25.29347  0.500 37.38696 ? 288 GLU A HB2  1 
ATOM   4360 H HB2  B GLU A 1 288 ? -11.07114 -14.02779 26.59496  0.500 37.51160 ? 288 GLU A HB2  1 
ATOM   4361 H HB3  A GLU A 1 288 ? -11.00593 -13.88310 26.61641  0.500 37.38696 ? 288 GLU A HB3  1 
ATOM   4362 H HB3  B GLU A 1 288 ? -11.07408 -14.87996 25.25362  0.500 37.51160 ? 288 GLU A HB3  1 
ATOM   4363 H HG2  A GLU A 1 288 ? -10.42905 -15.93235 25.88463  0.500 40.79988 ? 288 GLU A HG2  1 
ATOM   4364 H HG2  B GLU A 1 288 ? -9.52833  -12.55669 25.62226  0.500 38.12344 ? 288 GLU A HG2  1 
ATOM   4365 H HG3  A GLU A 1 288 ? -11.96622 -15.77945 25.51162  0.500 40.79988 ? 288 GLU A HG3  1 
ATOM   4366 H HG3  B GLU A 1 288 ? -8.94746  -14.03298 25.71488  0.500 38.12344 ? 288 GLU A HG3  1 
ATOM   4367 N N    . ASP A 1 289 ? -14.11471 -14.40390 24.48551  1.000 25.50227 ? 289 ASP A N    1 
ATOM   4368 C CA   . ASP A 1 289 ? -15.45346 -14.94929 24.68788  1.000 26.39670 ? 289 ASP A CA   1 
ATOM   4369 C C    . ASP A 1 289 ? -15.57270 -16.41854 24.29041  1.000 27.20139 ? 289 ASP A C    1 
ATOM   4370 O O    . ASP A 1 289 ? -16.69325 -16.91327 24.13153  1.000 23.26356 ? 289 ASP A O    1 
ATOM   4371 C CB   . ASP A 1 289 ? -16.48948 -14.12636 23.91496  1.000 25.20978 ? 289 ASP A CB   1 
ATOM   4372 C CG   . ASP A 1 289 ? -16.52639 -14.46708 22.43346  1.000 28.86120 ? 289 ASP A CG   1 
ATOM   4373 O OD1  . ASP A 1 289 ? -15.48646 -14.88655 21.88167  1.000 26.36647 ? 289 ASP A OD1  1 
ATOM   4374 O OD2  . ASP A 1 289 ? -17.60357 -14.31126 21.81881  1.000 25.18028 ? 289 ASP A OD2  1 
ATOM   4375 H H    . ASP A 1 289 ? -13.78602 -14.55680 23.70565  1.000 30.62550 ? 289 ASP A H    1 
ATOM   4376 H HA   . ASP A 1 289 ? -15.64855 -14.89604 25.63657  1.000 31.69882 ? 289 ASP A HA   1 
ATOM   4377 H HB2  . ASP A 1 289 ? -17.36960 -14.29921 24.28431  1.000 30.27451 ? 289 ASP A HB2  1 
ATOM   4378 H HB3  . ASP A 1 289 ? -16.27278 -13.18477 24.00068  1.000 30.27451 ? 289 ASP A HB3  1 
ATOM   4379 N N    . GLU A 1 290 ? -14.45994 -17.13853 24.13470  1.000 26.67672 ? 290 GLU A N    1 
ATOM   4380 C CA   . GLU A 1 290 ? -14.51218 -18.54882 23.76550  1.000 27.34862 ? 290 GLU A CA   1 
ATOM   4381 C C    . GLU A 1 290 ? -14.26948 -19.47722 24.95328  1.000 31.14826 ? 290 GLU A C    1 
ATOM   4382 O O    . GLU A 1 290 ? -13.91328 -20.64499 24.75757  1.000 28.91616 ? 290 GLU A O    1 
ATOM   4383 C CB   . GLU A 1 290 ? -13.51348 -18.84629 22.64367  1.000 30.60302 ? 290 GLU A CB   1 
ATOM   4384 C CG   . GLU A 1 290 ? -13.75180 -18.02388 21.37881  1.000 34.07661 ? 290 GLU A CG   1 
ATOM   4385 C CD   . GLU A 1 290 ? -13.81005 -18.86909 20.11209  1.000 39.29085 ? 290 GLU A CD   1 
ATOM   4386 O OE1  . GLU A 1 290 ? -13.18098 -19.94841 20.07498  1.000 35.72343 ? 290 GLU A OE1  1 
ATOM   4387 O OE2  . GLU A 1 290 ? -14.49295 -18.45150 19.15054  1.000 35.53549 ? 290 GLU A OE2  1 
ATOM   4388 H H    . GLU A 1 290 ? -13.66414 -16.82936 24.23821  1.000 32.03484 ? 290 GLU A H    1 
ATOM   4389 H HA   . GLU A 1 290 ? -15.40107 -18.73678 23.42572  1.000 32.84112 ? 290 GLU A HA   1 
ATOM   4390 H HB2  . GLU A 1 290 ? -12.61857 -18.64908 22.96169  1.000 36.74640 ? 290 GLU A HB2  1 
ATOM   4391 H HB3  . GLU A 1 290 ? -13.58170 -19.78404 22.40522  1.000 36.74640 ? 290 GLU A HB3  1 
ATOM   4392 H HG2  . GLU A 1 290 ? -14.59713 -17.55572 21.46332  1.000 40.91471 ? 290 GLU A HG2  1 
ATOM   4393 H HG3  . GLU A 1 290 ? -13.02796 -17.38608 21.27797  1.000 40.91471 ? 290 GLU A HG3  1 
ATOM   4394 N N    . PHE A 1 291 ? -14.46528 -18.98911 26.17625  1.000 27.60651 ? 291 PHE A N    1 
ATOM   4395 C CA   . PHE A 1 291 ? -14.43856 -19.81993 27.37386  1.000 30.80795 ? 291 PHE A CA   1 
ATOM   4396 C C    . PHE A 1 291 ? -15.81912 -19.81146 28.01183  1.000 30.03628 ? 291 PHE A C    1 
ATOM   4397 O O    . PHE A 1 291 ? -16.30307 -18.75344 28.42605  1.000 25.23534 ? 291 PHE A O    1 
ATOM   4398 C CB   . PHE A 1 291 ? -13.41278 -19.31364 28.38605  1.000 32.97346 ? 291 PHE A CB   1 
ATOM   4399 C CG   . PHE A 1 291 ? -11.98814 -19.46933 27.94702  1.000 35.58174 ? 291 PHE A CG   1 
ATOM   4400 C CD1  . PHE A 1 291 ? -11.36892 -20.70747 27.98657  1.000 37.91345 ? 291 PHE A CD1  1 
ATOM   4401 C CD2  . PHE A 1 291 ? -11.25868 -18.37333 27.51782  1.000 31.76287 ? 291 PHE A CD2  1 
ATOM   4402 C CE1  . PHE A 1 291 ? -10.05382 -20.85066 27.59154  1.000 39.64536 ? 291 PHE A CE1  1 
ATOM   4403 C CE2  . PHE A 1 291 ? -9.94163  -18.51119 27.12303  1.000 37.28903 ? 291 PHE A CE2  1 
ATOM   4404 C CZ   . PHE A 1 291 ? -9.33918  -19.75033 27.16005  1.000 36.48169 ? 291 PHE A CZ   1 
ATOM   4405 H H    . PHE A 1 291 ? -14.61913 -18.15890 26.33959  1.000 33.15059 ? 291 PHE A H    1 
ATOM   4406 H HA   . PHE A 1 291 ? -14.20772 -20.72608 27.11598  1.000 36.99232 ? 291 PHE A HA   1 
ATOM   4407 H HB2  . PHE A 1 291 ? -13.57099 -18.36946 28.54222  1.000 39.59092 ? 291 PHE A HB2  1 
ATOM   4408 H HB3  . PHE A 1 291 ? -13.52177 -19.80945 29.21260  1.000 39.59092 ? 291 PHE A HB3  1 
ATOM   4409 H HD1  . PHE A 1 291 ? -11.84398 -21.45026 28.28234  1.000 45.51892 ? 291 PHE A HD1  1 
ATOM   4410 H HD2  . PHE A 1 291 ? -11.65988 -17.53463 27.49500  1.000 38.13822 ? 291 PHE A HD2  1 
ATOM   4411 H HE1  . PHE A 1 291 ? -9.64929  -21.68771 27.61597  1.000 47.59720 ? 291 PHE A HE1  1 
ATOM   4412 H HE2  . PHE A 1 291 ? -9.46239  -17.76892 26.83275  1.000 44.76961 ? 291 PHE A HE2  1 
ATOM   4413 H HZ   . PHE A 1 291 ? -8.45286  -19.84536 26.89489  1.000 43.80081 ? 291 PHE A HZ   1 
ATOM   4414 N N    . THR A 1 292 ? -16.44205 -20.98158 28.11157  1.000 28.05830 ? 292 THR A N    1 
ATOM   4415 C CA   . THR A 1 292 ? -17.69993 -21.06133 28.82677  1.000 29.91250 ? 292 THR A CA   1 
ATOM   4416 C C    . THR A 1 292 ? -17.45152 -20.99159 30.32978  1.000 31.79357 ? 292 THR A C    1 
ATOM   4417 O O    . THR A 1 292 ? -16.32330 -21.17039 30.79762  1.000 30.61998 ? 292 THR A O    1 
ATOM   4418 C CB   . THR A 1 292 ? -18.44063 -22.35517 28.50385  1.000 32.02787 ? 292 THR A CB   1 
ATOM   4419 O OG1  . THR A 1 292 ? -17.68131 -23.46862 28.98257  1.000 32.05184 ? 292 THR A OG1  1 
ATOM   4420 C CG2  . THR A 1 292 ? -18.66919 -22.50046 27.00701  1.000 29.48472 ? 292 THR A CG2  1 
ATOM   4421 H H    . THR A 1 292 ? -16.15987 -21.72330 27.78018  1.000 33.69273 ? 292 THR A H    1 
ATOM   4422 H HA   . THR A 1 292 ? -18.26307 -20.32073 28.55241  1.000 35.91778 ? 292 THR A HA   1 
ATOM   4423 H HB   . THR A 1 292 ? -19.30958 -22.34201 28.93472  1.000 38.45622 ? 292 THR A HB   1 
ATOM   4424 H HG1  . THR A 1 292 ? -18.07081 -23.82156 29.63779  1.000 38.48498 ? 292 THR A HG1  1 
ATOM   4425 H HG21 . THR A 1 292 ? -17.82001 -22.48304 26.53851  1.000 35.40444 ? 292 THR A HG21 1 
ATOM   4426 H HG22 . THR A 1 292 ? -19.11495 -23.34132 26.81954  1.000 35.40444 ? 292 THR A HG22 1 
ATOM   4427 H HG23 . THR A 1 292 ? -19.22214 -21.77208 26.68359  1.000 35.40444 ? 292 THR A HG23 1 
ATOM   4428 N N    . PRO A 1 293 ? -18.49918 -20.73189 31.11035  1.000 26.46291 ? 293 PRO A N    1 
ATOM   4429 C CA   . PRO A 1 293 ? -18.36632 -20.86760 32.57057  1.000 29.52260 ? 293 PRO A CA   1 
ATOM   4430 C C    . PRO A 1 293 ? -17.92833 -22.26153 32.99415  1.000 37.96404 ? 293 PRO A C    1 
ATOM   4431 O O    . PRO A 1 293 ? -17.06298 -22.40270 33.86806  1.000 32.51107 ? 293 PRO A O    1 
ATOM   4432 C CB   . PRO A 1 293 ? -19.77612 -20.51754 33.07102  1.000 24.87414 ? 293 PRO A CB   1 
ATOM   4433 C CG   . PRO A 1 293 ? -20.33339 -19.62231 31.99405  1.000 28.83042 ? 293 PRO A CG   1 
ATOM   4434 C CD   . PRO A 1 293 ? -19.81380 -20.19726 30.71725  1.000 27.50323 ? 293 PRO A CD   1 
ATOM   4435 H HA   . PRO A 1 293 ? -17.73636 -20.21736 32.91877  1.000 35.44990 ? 293 PRO A HA   1 
ATOM   4436 H HB2  . PRO A 1 293 ? -20.30677 -21.32392 33.16623  1.000 29.87175 ? 293 PRO A HB2  1 
ATOM   4437 H HB3  . PRO A 1 293 ? -19.72329 -20.05289 33.92085  1.000 29.87175 ? 293 PRO A HB3  1 
ATOM   4438 H HG2  . PRO A 1 293 ? -21.30296 -19.64176 32.01509  1.000 34.61928 ? 293 PRO A HG2  1 
ATOM   4439 H HG3  . PRO A 1 293 ? -20.01695 -18.71416 32.12072  1.000 34.61928 ? 293 PRO A HG3  1 
ATOM   4440 H HD2  . PRO A 1 293 ? -20.39349 -20.90462 30.39399  1.000 33.02665 ? 293 PRO A HD2  1 
ATOM   4441 H HD3  . PRO A 1 293 ? -19.72016 -19.50944 30.03973  1.000 33.02665 ? 293 PRO A HD3  1 
ATOM   4442 N N    . PHE A 1 294 ? -18.51075 -23.30001 32.38769  1.000 36.86047 ? 294 PHE A N    1 
ATOM   4443 C CA   . PHE A 1 294 ? -18.07560 -24.67064 32.64513  1.000 37.44965 ? 294 PHE A CA   1 
ATOM   4444 C C    . PHE A 1 294 ? -16.58491 -24.83111 32.36517  1.000 39.83813 ? 294 PHE A C    1 
ATOM   4445 O O    . PHE A 1 294 ? -15.86552 -25.47870 33.13565  1.000 40.60239 ? 294 PHE A O    1 
ATOM   4446 C CB   . PHE A 1 294 ? -18.90849 -25.62422 31.78096  1.000 42.24157 ? 294 PHE A CB   1 
ATOM   4447 C CG   . PHE A 1 294 ? -18.76709 -27.08858 32.12700  1.000 54.41844 ? 294 PHE A CG   1 
ATOM   4448 C CD1  . PHE A 1 294 ? -17.94957 -27.52467 33.15666  1.000 56.62550 ? 294 PHE A CD1  1 
ATOM   4449 C CD2  . PHE A 1 294 ? -19.46855 -28.03561 31.39586  1.000 73.02229 ? 294 PHE A CD2  1 
ATOM   4450 C CE1  . PHE A 1 294 ? -17.84070 -28.87556 33.44757  1.000 64.66869 ? 294 PHE A CE1  1 
ATOM   4451 C CE2  . PHE A 1 294 ? -19.35989 -29.38213 31.68249  1.000 70.32754 ? 294 PHE A CE2  1 
ATOM   4452 C CZ   . PHE A 1 294 ? -18.54436 -29.80214 32.70801  1.000 65.17789 ? 294 PHE A CZ   1 
ATOM   4453 H H    . PHE A 1 294 ? -19.15787 -23.23690 31.82480  1.000 44.25534 ? 294 PHE A H    1 
ATOM   4454 H HA   . PHE A 1 294 ? -18.22107 -24.89666 33.57715  1.000 44.96236 ? 294 PHE A HA   1 
ATOM   4455 H HB2  . PHE A 1 294 ? -19.84467 -25.39093 31.88124  1.000 50.71267 ? 294 PHE A HB2  1 
ATOM   4456 H HB3  . PHE A 1 294 ? -18.63701 -25.51660 30.85596  1.000 50.71267 ? 294 PHE A HB3  1 
ATOM   4457 H HD1  . PHE A 1 294 ? -17.46930 -26.90539 33.65741  1.000 67.97337 ? 294 PHE A HD1  1 
ATOM   4458 H HD2  . PHE A 1 294 ? -20.02135 -27.75923 30.70093  1.000 87.64952 ? 294 PHE A HD2  1 
ATOM   4459 H HE1  . PHE A 1 294 ? -17.29171 -29.15752 34.14328  1.000 77.62521 ? 294 PHE A HE1  1 
ATOM   4460 H HE2  . PHE A 1 294 ? -19.83744 -30.00441 31.18288  1.000 84.41582 ? 294 PHE A HE2  1 
ATOM   4461 H HZ   . PHE A 1 294 ? -18.46802 -30.70854 32.90172  1.000 78.23625 ? 294 PHE A HZ   1 
ATOM   4462 N N    . ASP A 1 295 ? -16.09939 -24.23042 31.27463  1.000 37.23577 ? 295 ASP A N    1 
ATOM   4463 C CA   . ASP A 1 295 ? -14.68610 -24.34696 30.92647  1.000 35.28272 ? 295 ASP A CA   1 
ATOM   4464 C C    . ASP A 1 295 ? -13.79280 -23.77373 32.02077  1.000 39.44982 ? 295 ASP A C    1 
ATOM   4465 O O    . ASP A 1 295 ? -12.75092 -24.35379 32.34835  1.000 38.90890 ? 295 ASP A O    1 
ATOM   4466 C CB   . ASP A 1 295 ? -14.40036 -23.62861 29.60536  1.000 33.29005 ? 295 ASP A CB   1 
ATOM   4467 C CG   . ASP A 1 295 ? -15.02955 -24.31302 28.40021  1.000 35.86485 ? 295 ASP A CG   1 
ATOM   4468 O OD1  . ASP A 1 295 ? -15.29978 -25.52981 28.45758  1.000 33.64790 ? 295 ASP A OD1  1 
ATOM   4469 O OD2  . ASP A 1 295 ? -15.24069 -23.62125 27.38029  1.000 30.80425 ? 295 ASP A OD2  1 
ATOM   4470 H H    . ASP A 1 295 ? -16.56301 -23.75577 30.72749  1.000 44.70570 ? 295 ASP A H    1 
ATOM   4471 H HA   . ASP A 1 295 ? -14.48063 -25.28871 30.81793  1.000 42.36204 ? 295 ASP A HA   1 
ATOM   4472 H HB2  . ASP A 1 295 ? -14.75530 -22.72724 29.65479  1.000 39.97084 ? 295 ASP A HB2  1 
ATOM   4473 H HB3  . ASP A 1 295 ? -13.44108 -23.60015 29.46439  1.000 39.97084 ? 295 ASP A HB3  1 
ATOM   4474 N N    . VAL A 1 296 ? -14.16829 -22.61881 32.57828  1.000 33.49670 ? 296 VAL A N    1 
ATOM   4475 C CA   . VAL A 1 296 ? -13.33110 -21.97519 33.58742  1.000 37.81445 ? 296 VAL A CA   1 
ATOM   4476 C C    . VAL A 1 296 ? -13.30165 -22.80280 34.86683  1.000 36.62706 ? 296 VAL A C    1 
ATOM   4477 O O    . VAL A 1 296 ? -12.24021 -22.99399 35.47268  1.000 38.70622 ? 296 VAL A O    1 
ATOM   4478 C CB   . VAL A 1 296 ? -13.82271 -20.53931 33.85021  1.000 37.65484 ? 296 VAL A CB   1 
ATOM   4479 C CG1  . VAL A 1 296 ? -12.98841 -19.87230 34.94369  1.000 36.23879 ? 296 VAL A CG1  1 
ATOM   4480 C CG2  . VAL A 1 296 ? -13.76963 -19.72487 32.56824  1.000 31.17158 ? 296 VAL A CG2  1 
ATOM   4481 H H    . VAL A 1 296 ? -14.89281 -22.19488 32.39134  1.000 40.21881 ? 296 VAL A H    1 
ATOM   4482 H HA   . VAL A 1 296 ? -12.42425 -21.92414 33.24697  1.000 45.40012 ? 296 VAL A HA   1 
ATOM   4483 H HB   . VAL A 1 296 ? -14.74257 -20.57365 34.15612  1.000 45.20858 ? 296 VAL A HB   1 
ATOM   4484 H HG11 . VAL A 1 296 ? -13.28566 -18.95542 35.05266  1.000 43.50932 ? 296 VAL A HG11 1 
ATOM   4485 H HG12 . VAL A 1 296 ? -13.10808 -20.35969 35.77376  1.000 43.50932 ? 296 VAL A HG12 1 
ATOM   4486 H HG13 . VAL A 1 296 ? -12.05442 -19.88839 34.68235  1.000 43.50932 ? 296 VAL A HG13 1 
ATOM   4487 H HG21 . VAL A 1 296 ? -13.98722 -18.80167 32.77137  1.000 37.42867 ? 296 VAL A HG21 1 
ATOM   4488 H HG22 . VAL A 1 296 ? -12.87559 -19.77979 32.19599  1.000 37.42867 ? 296 VAL A HG22 1 
ATOM   4489 H HG23 . VAL A 1 296 ? -14.41299 -20.08542 31.93817  1.000 37.42867 ? 296 VAL A HG23 1 
ATOM   4490 N N    . VAL A 1 297 ? -14.46247 -23.29603 35.30452  1.000 35.87210 ? 297 VAL A N    1 
ATOM   4491 C CA   . VAL A 1 297 ? -14.51294 -24.14933 36.49021  1.000 40.30609 ? 297 VAL A CA   1 
ATOM   4492 C C    . VAL A 1 297 ? -13.62985 -25.37676 36.29907  1.000 44.37350 ? 297 VAL A C    1 
ATOM   4493 O O    . VAL A 1 297 ? -12.80867 -25.71207 37.16075  1.000 49.51370 ? 297 VAL A O    1 
ATOM   4494 C CB   . VAL A 1 297 ? -15.96741 -24.54710 36.80183  1.000 42.08784 ? 297 VAL A CB   1 
ATOM   4495 C CG1  . VAL A 1 297 ? -16.01199 -25.69143 37.80927  1.000 41.53819 ? 297 VAL A CG1  1 
ATOM   4496 C CG2  . VAL A 1 297 ? -16.74215 -23.34940 37.32213  1.000 40.12060 ? 297 VAL A CG2  1 
ATOM   4497 H H    . VAL A 1 297 ? -15.22640 -23.15280 34.93642  1.000 43.06929 ? 297 VAL A H    1 
ATOM   4498 H HA   . VAL A 1 297 ? -14.16840 -23.64738 37.24535  1.000 48.39008 ? 297 VAL A HA   1 
ATOM   4499 H HB   . VAL A 1 297 ? -16.38880 -24.85286 35.98339  1.000 50.52819 ? 297 VAL A HB   1 
ATOM   4500 H HG11 . VAL A 1 297 ? -16.90569 -25.74951 38.18186  1.000 49.86860 ? 297 VAL A HG11 1 
ATOM   4501 H HG12 . VAL A 1 297 ? -15.78785 -26.51956 37.35665  1.000 49.86860 ? 297 VAL A HG12 1 
ATOM   4502 H HG13 . VAL A 1 297 ? -15.37013 -25.51600 38.51506  1.000 49.86860 ? 297 VAL A HG13 1 
ATOM   4503 H HG21 . VAL A 1 297 ? -17.66146 -23.61367 37.48315  1.000 48.16750 ? 297 VAL A HG21 1 
ATOM   4504 H HG22 . VAL A 1 297 ? -16.33578 -23.04527 38.14872  1.000 48.16750 ? 297 VAL A HG22 1 
ATOM   4505 H HG23 . VAL A 1 297 ? -16.71263 -22.64195 36.65915  1.000 48.16750 ? 297 VAL A HG23 1 
ATOM   4506 N N    . ARG A 1 298 ? -13.79200 -26.07066 35.16865  1.000 45.25406 ? 298 ARG A N    1 
ATOM   4507 C CA   . ARG A 1 298 ? -13.01604 -27.28376 34.92262  1.000 46.08916 ? 298 ARG A CA   1 
ATOM   4508 C C    . ARG A 1 298 ? -11.52053 -27.02557 35.03426  1.000 48.69804 ? 298 ARG A C    1 
ATOM   4509 O O    . ARG A 1 298 ? -10.79169 -27.80382 35.65961  1.000 48.87700 ? 298 ARG A O    1 
ATOM   4510 C CB   . ARG A 1 298 ? -13.34238 -27.85359 33.54170  1.000 49.45661 ? 298 ARG A CB   1 
ATOM   4511 C CG   . ARG A 1 298 ? -14.58021 -28.71697 33.52716  1.000 54.23854 ? 298 ARG A CG   1 
ATOM   4512 C CD   . ARG A 1 298 ? -14.68084 -29.58867 32.27784  1.000 55.83858 ? 298 ARG A CD   1 
ATOM   4513 N NE   . ARG A 1 298 ? -15.09953 -28.84935 31.09112  1.000 58.33280 ? 298 ARG A NE   1 
ATOM   4514 C CZ   . ARG A 1 298 ? -14.28676 -28.42208 30.13236  1.000 58.28497 ? 298 ARG A CZ   1 
ATOM   4515 N NH1  . ARG A 1 298 ? -12.97763 -28.61200 30.19369  1.000 56.64759 ? 298 ARG A NH1  1 
ATOM   4516 N NH2  . ARG A 1 298 ? -14.80231 -27.79209 29.08018  1.000 50.35050 ? 298 ARG A NH2  1 
ATOM   4517 H H    . ARG A 1 298 ? -14.33780 -25.86189 34.53768  1.000 54.32765 ? 298 ARG A H    1 
ATOM   4518 H HA   . ARG A 1 298 ? -13.26494 -27.93771 35.59441  1.000 55.32977 ? 298 ARG A HA   1 
ATOM   4519 H HB2  . ARG A 1 298 ? -13.48492 -27.11841 32.92518  1.000 59.37072 ? 298 ARG A HB2  1 
ATOM   4520 H HB3  . ARG A 1 298 ? -12.59666 -28.39724 33.24296  1.000 59.37072 ? 298 ARG A HB3  1 
ATOM   4521 H HG2  . ARG A 1 298 ? -14.56610 -29.30274 34.30019  1.000 65.10903 ? 298 ARG A HG2  1 
ATOM   4522 H HG3  . ARG A 1 298 ? -15.36399 -28.14631 33.55758  1.000 65.10903 ? 298 ARG A HG3  1 
ATOM   4523 H HD2  . ARG A 1 298 ? -13.81114 -29.97730 32.09486  1.000 67.02907 ? 298 ARG A HD2  1 
ATOM   4524 H HD3  . ARG A 1 298 ? -15.33129 -30.29068 32.43596  1.000 67.02907 ? 298 ARG A HD3  1 
ATOM   4525 H HE   . ARG A 1 298 ? -15.93784 -28.67713 31.00638  1.000 70.02214 ? 298 ARG A HE   1 
ATOM   4526 H HH11 . ARG A 1 298 ? -12.63361 -29.02144 30.86720  1.000 67.99989 ? 298 ARG A HH11 1 
ATOM   4527 H HH12 . ARG A 1 298 ? -12.47147 -28.32590 29.56001  1.000 67.99989 ? 298 ARG A HH12 1 
ATOM   4528 H HH21 . ARG A 1 298 ? -15.65147 -27.66647 29.02779  1.000 60.44338 ? 298 ARG A HH21 1 
ATOM   4529 H HH22 . ARG A 1 298 ? -14.28643 -27.51044 28.45237  1.000 60.44338 ? 298 ARG A HH22 1 
ATOM   4530 N N    . GLN A 1 299 ? -11.04143 -25.94161 34.42382  1.000 45.90192 ? 299 GLN A N    1 
ATOM   4531 C CA   . GLN A 1 299 ? -9.60592  -25.68752 34.40090  1.000 45.23457 ? 299 GLN A CA   1 
ATOM   4532 C C    . GLN A 1 299 ? -9.10606  -25.17956 35.74700  1.000 49.06610 ? 299 GLN A C    1 
ATOM   4533 O O    . GLN A 1 299 ? -8.00239  -25.53593 36.17494  1.000 48.01770 ? 299 GLN A O    1 
ATOM   4534 C CB   . GLN A 1 299 ? -9.26663  -24.69089 33.29173  1.000 39.89249 ? 299 GLN A CB   1 
ATOM   4535 C CG   . GLN A 1 299 ? -7.76868  -24.44307 33.13090  1.000 33.11829 ? 299 GLN A CG   1 
ATOM   4536 C CD   . GLN A 1 299 ? -7.40161  -23.64698 31.88315  1.000 33.66139 ? 299 GLN A CD   1 
ATOM   4537 O OE1  . GLN A 1 299 ? -6.27556  -23.16535 31.76433  1.000 31.00622 ? 299 GLN A OE1  1 
ATOM   4538 N NE2  . GLN A 1 299 ? -8.33921  -23.51491 30.94647  1.000 33.05184 ? 299 GLN A NE2  1 
ATOM   4539 H H    . GLN A 1 299 ? -11.51906 -25.34927 34.02307  1.000 55.10508 ? 299 GLN A H    1 
ATOM   4540 H HA   . GLN A 1 299 ? -9.14492  -26.51840 34.20594  1.000 54.30427 ? 299 GLN A HA   1 
ATOM   4541 H HB2  . GLN A 1 299 ? -9.60291  -25.03448 32.44926  1.000 47.89377 ? 299 GLN A HB2  1 
ATOM   4542 H HB3  . GLN A 1 299 ? -9.68799  -23.84125 33.49539  1.000 47.89377 ? 299 GLN A HB3  1 
ATOM   4543 H HG2  . GLN A 1 299 ? -7.45092  -23.94649 33.90118  1.000 39.76473 ? 299 GLN A HG2  1 
ATOM   4544 H HG3  . GLN A 1 299 ? -7.31553  -25.29908 33.07803  1.000 39.76473 ? 299 GLN A HG3  1 
ATOM   4545 H HE21 . GLN A 1 299 ? -9.11351  -23.87158 31.05981  1.000 39.68499 ? 299 GLN A HE21 1 
ATOM   4546 H HE22 . GLN A 1 299 ? -8.17032  -23.07297 30.22830  1.000 39.68499 ? 299 GLN A HE22 1 
ATOM   4547 N N    . CYS A 1 300 ? -9.89993  -24.35252 36.42740  1.000 46.95472 ? 300 CYS A N    1 
ATOM   4548 C CA   . CYS A 1 300 ? -9.54233  -23.83185 37.73988  1.000 50.27319 ? 300 CYS A CA   1 
ATOM   4549 C C    . CYS A 1 300 ? -9.90938  -24.78699 38.87452  1.000 54.64255 ? 300 CYS A C    1 
ATOM   4550 O O    . CYS A 1 300 ? -10.01361 -24.35062 40.02829  1.000 53.19723 ? 300 CYS A O    1 
ATOM   4551 C CB   . CYS A 1 300 ? -10.20488 -22.46899 37.96078  1.000 47.55602 ? 300 CYS A CB   1 
ATOM   4552 S SG   . CYS A 1 300 ? -9.67219  -21.19482 36.78831  1.000 55.03958 ? 300 CYS A SG   1 
ATOM   4553 H H    . CYS A 1 300 ? -10.66265 -24.07595 36.14216  1.000 56.36844 ? 300 CYS A H    1 
ATOM   4554 H HA   . CYS A 1 300 ? -8.58162  -23.70071 37.76719  1.000 60.35061 ? 300 CYS A HA   1 
ATOM   4555 H HB2  . CYS A 1 300 ? -11.16515 -22.57151 37.86978  1.000 57.09000 ? 300 CYS A HB2  1 
ATOM   4556 H HB3  . CYS A 1 300 ? -9.98753  -22.15848 38.85366  1.000 57.09000 ? 300 CYS A HB3  1 
ATOM   4557 H HG   . CYS A 1 300 ? -9.88027  -21.58036 35.67114  1.000 66.07027 ? 300 CYS A HG   1 
ATOM   4558 N N    . SER A 1 301 ? -10.12100 -26.07290 38.56967  1.000 57.68717 ? 301 SER A N    1 
ATOM   4559 C CA   . SER A 1 301 ? -10.28104 -27.06942 39.62250  1.000 55.53432 ? 301 SER A CA   1 
ATOM   4560 C C    . SER A 1 301 ? -9.77437  -28.44908 39.21302  1.000 55.52999 ? 301 SER A C    1 
ATOM   4561 O O    . SER A 1 301 ? -9.91403  -29.39124 40.00152  1.000 55.53066 ? 301 SER A O    1 
ATOM   4562 C CB   . SER A 1 301 ? -11.75356 -27.15793 40.05687  1.000 61.35461 ? 301 SER A CB   1 
ATOM   4563 O OG   . SER A 1 301 ? -12.55873 -27.73961 39.04663  1.000 63.50364 ? 301 SER A OG   1 
ATOM   4564 H H    . SER A 1 301 ? -10.17472 -26.38581 37.77042  1.000 69.24738 ? 301 SER A H    1 
ATOM   4565 H HA   . SER A 1 301 ? -9.77417  -26.78591 40.39942  1.000 66.66396 ? 301 SER A HA   1 
ATOM   4566 H HB2  . SER A 1 301 ? -11.81186 -27.70361 40.85670  1.000 73.64831 ? 301 SER A HB2  1 
ATOM   4567 H HB3  . SER A 1 301 ? -12.08002 -26.26329 40.24110  1.000 73.64831 ? 301 SER A HB3  1 
ATOM   4568 H HG   . SER A 1 301 ? -12.38721 -28.55912 38.97888  1.000 76.22715 ? 301 SER A HG   1 
ATOM   4569 N N    . GLY A 1 302 ? -9.21138  -28.61220 38.01518  1.000 58.23749 ? 302 GLY A N    1 
ATOM   4570 C CA   . GLY A 1 302 ? -8.48057  -29.82060 37.68062  1.000 49.07959 ? 302 GLY A CA   1 
ATOM   4571 C C    . GLY A 1 302 ? -9.31870  -31.02521 37.31934  1.000 50.44349 ? 302 GLY A C    1 
ATOM   4572 O O    . GLY A 1 302 ? -8.92447  -32.15533 37.62584  1.000 49.88054 ? 302 GLY A O    1 
ATOM   4573 H H    . GLY A 1 302 ? -9.24124  -28.03304 37.38013  1.000 69.90776 ? 302 GLY A H    1 
ATOM   4574 H HA2  . GLY A 1 302 ? -7.90452  -29.63005 36.92381  1.000 58.91829 ? 302 GLY A HA2  1 
ATOM   4575 H HA3  . GLY A 1 302 ? -7.93142  -30.06649 38.44145  1.000 58.91829 ? 302 GLY A HA3  1 
ATOM   4576 N N    . VAL A 1 303 ? -10.46012 -30.82535 36.66901  1.000 52.32824 ? 303 VAL A N    1 
ATOM   4577 C CA   . VAL A 1 303 ? -11.31037 -31.94196 36.26772  1.000 60.57065 ? 303 VAL A CA   1 
ATOM   4578 C C    . VAL A 1 303 ? -10.57376 -32.84816 35.28165  1.000 51.98072 ? 303 VAL A C    1 
ATOM   4579 O O    . VAL A 1 303 ? -10.00947 -32.38372 34.29097  1.000 47.06711 ? 303 VAL A O    1 
ATOM   4580 C CB   . VAL A 1 303 ? -12.63746 -31.44098 35.66291  1.000 53.16774 ? 303 VAL A CB   1 
ATOM   4581 C CG1  . VAL A 1 303 ? -13.33892 -32.56499 34.90955  1.000 54.88954 ? 303 VAL A CG1  1 
ATOM   4582 C CG2  . VAL A 1 303 ? -13.53841 -30.88152 36.75968  1.000 53.51027 ? 303 VAL A CG2  1 
ATOM   4583 H H    . VAL A 1 303 ? -10.76515 -30.05225 36.44794  1.000 62.81666 ? 303 VAL A H    1 
ATOM   4584 H HA   . VAL A 1 303 ? -11.52257 -32.46678 37.05540  1.000 72.70755 ? 303 VAL A HA   1 
ATOM   4585 H HB   . VAL A 1 303 ? -12.44951 -30.72930 35.03116  1.000 63.82407 ? 303 VAL A HB   1 
ATOM   4586 H HG11 . VAL A 1 303 ? -13.16022 -33.40587 35.35887  1.000 65.89023 ? 303 VAL A HG11 1 
ATOM   4587 H HG12 . VAL A 1 303 ? -14.29319 -32.39130 34.90003  1.000 65.89023 ? 303 VAL A HG12 1 
ATOM   4588 H HG13 . VAL A 1 303 ? -12.99936 -32.59649 34.00147  1.000 65.89023 ? 303 VAL A HG13 1 
ATOM   4589 H HG21 . VAL A 1 303 ? -13.01242 -30.75013 37.56403  1.000 64.23510 ? 303 VAL A HG21 1 
ATOM   4590 H HG22 . VAL A 1 303 ? -13.90751 -30.03469 36.46382  1.000 64.23510 ? 303 VAL A HG22 1 
ATOM   4591 H HG23 . VAL A 1 303 ? -14.25477 -31.51234 36.93229  1.000 64.23510 ? 303 VAL A HG23 1 
HETATM 4592 C C7   . UED B 2 .   ? -14.65240 -22.80215 -0.18185  1.000 29.18144 ? 401 UED A C7   1 
HETATM 4593 O O8   . UED B 2 .   ? -15.15486 -24.05300 -0.63219  1.000 29.90560 ? 401 UED A O8   1 
HETATM 4594 C C9   . UED B 2 .   ? -15.34590 -25.04946 0.25238   1.000 30.88575 ? 401 UED A C9   1 
HETATM 4595 O O10  . UED B 2 .   ? -14.99234 -25.01433 1.43444   1.000 27.22747 ? 401 UED A O10  1 
HETATM 4596 C C1   . UED B 2 .   ? -13.13728 -22.84104 -0.18938  1.000 33.37126 ? 401 UED A C1   1 
HETATM 4597 C C2   . UED B 2 .   ? -12.46814 -23.80385 -0.94867  1.000 32.53771 ? 401 UED A C2   1 
HETATM 4598 C C3   . UED B 2 .   ? -11.07618 -23.84025 -0.95588  1.000 35.74563 ? 401 UED A C3   1 
HETATM 4599 C C4   . UED B 2 .   ? -10.36038 -22.91359 -0.20079  1.000 32.02666 ? 401 UED A C4   1 
HETATM 4600 C C5   . UED B 2 .   ? -11.02605 -21.95643 0.56083   1.000 34.80623 ? 401 UED A C5   1 
HETATM 4601 C C6   . UED B 2 .   ? -12.41772 -21.91652 0.56792   1.000 32.59286 ? 401 UED A C6   1 
HETATM 4602 N N11  . UED B 2 .   ? -15.99395 -26.11406 -0.36070  1.000 31.10944 ? 401 UED A N11  1 
HETATM 4603 C C12  . UED B 2 .   ? -15.99573 -27.43334 0.29523   1.000 27.85179 ? 401 UED A C12  1 
HETATM 4604 C C17  . UED B 2 .   ? -14.55717 -27.91148 0.61162   1.000 27.67460 ? 401 UED A C17  1 
HETATM 4605 O O18  . UED B 2 .   ? -13.68801 -27.90948 -0.26122  1.000 30.37753 ? 401 UED A O18  1 
HETATM 4606 C C13  . UED B 2 .   ? -16.76330 -28.46519 -0.56299  1.000 32.09402 ? 401 UED A C13  1 
HETATM 4607 C C14  . UED B 2 .   ? -18.26613 -28.13509 -0.74475  1.000 29.12543 ? 401 UED A C14  1 
HETATM 4608 C C15  . UED B 2 .   ? -18.99764 -27.98134 0.60482   1.000 31.03605 ? 401 UED A C15  1 
HETATM 4609 C C16  . UED B 2 .   ? -18.95842 -29.16049 -1.67397  1.000 30.54618 ? 401 UED A C16  1 
HETATM 4610 N N19  . UED B 2 .   ? -14.34990 -28.30280 1.87932   1.000 22.02464 ? 401 UED A N19  1 
HETATM 4611 C C20  . UED B 2 .   ? -13.08457 -28.78011 2.44181   1.000 23.98990 ? 401 UED A C20  1 
HETATM 4612 C C21  . UED B 2 .   ? -13.21737 -30.27005 2.81965   1.000 23.60008 ? 401 UED A C21  1 
HETATM 4613 O O22  . UED B 2 .   ? -11.96113 -30.87771 3.03801   1.000 33.38561 ? 401 UED A O22  1 
HETATM 4614 C C24  . UED B 2 .   ? -12.63269 -27.82706 3.58624   1.000 22.24250 ? 401 UED A C24  1 
HETATM 4615 C C25  . UED B 2 .   ? -12.22943 -26.36655 3.16034   1.000 28.03514 ? 401 UED A C25  1 
HETATM 4616 C C26  . UED B 2 .   ? -11.01505 -26.28323 2.23341   1.000 30.04217 ? 401 UED A C26  1 
HETATM 4617 C C27  . UED B 2 .   ? -10.13776 -25.15591 2.73640   1.000 32.72115 ? 401 UED A C27  1 
HETATM 4618 N N28  . UED B 2 .   ? -10.56759 -24.88902 4.10069   1.000 29.61077 ? 401 UED A N28  1 
HETATM 4619 C C29  . UED B 2 .   ? -11.80385 -25.57284 4.40260   1.000 27.19240 ? 401 UED A C29  1 
HETATM 4620 O O30  . UED B 2 .   ? -12.34940 -25.48613 5.50272   1.000 22.87530 ? 401 UED A O30  1 
HETATM 4621 H H1   . UED B 2 .   ? -15.01019 -22.58328 0.82639   1.000 35.04050 ? 401 UED A H1   1 
HETATM 4622 H H2   . UED B 2 .   ? -15.00320 -21.99180 -0.82430  1.000 35.04050 ? 401 UED A H2   1 
HETATM 4623 H H3   . UED B 2 .   ? -13.02558 -24.52294 -1.53240  1.000 39.06803 ? 401 UED A H3   1 
HETATM 4624 H H4   . UED B 2 .   ? -10.55305 -24.58202 -1.54298  1.000 42.91753 ? 401 UED A H4   1 
HETATM 4625 H H5   . UED B 2 .   ? -9.28066  -22.93735 -0.20583  1.000 38.45477 ? 401 UED A H5   1 
HETATM 4626 H H6   . UED B 2 .   ? -10.46336 -21.24360 1.14719   1.000 41.79025 ? 401 UED A H6   1 
HETATM 4627 H H7   . UED B 2 .   ? -12.93350 -21.17112 1.15876   1.000 39.13421 ? 401 UED A H7   1 
HETATM 4628 H H8   . UED B 2 .   ? -16.46140 -25.99006 -1.24853  1.000 37.35410 ? 401 UED A H8   1 
HETATM 4629 H H9   . UED B 2 .   ? -16.54769 -27.36187 1.23591   1.000 33.44492 ? 401 UED A H9   1 
HETATM 4630 H H10  . UED B 2 .   ? -16.66228 -29.45584 -0.11237  1.000 38.53560 ? 401 UED A H10  1 
HETATM 4631 H H11  . UED B 2 .   ? -16.28853 -28.54277 -1.54444  1.000 38.53560 ? 401 UED A H11  1 
HETATM 4632 H H12  . UED B 2 .   ? -18.33306 -27.17735 -1.26294  1.000 34.97329 ? 401 UED A H12  1 
HETATM 4633 H H13  . UED B 2 .   ? -20.06290 -28.20137 0.52069   1.000 37.26604 ? 401 UED A H13  1 
HETATM 4634 H H14  . UED B 2 .   ? -18.91575 -26.96852 1.00203   1.000 37.26604 ? 401 UED A H14  1 
HETATM 4635 H H15  . UED B 2 .   ? -18.59689 -28.65167 1.36662   1.000 37.26604 ? 401 UED A H15  1 
HETATM 4636 H H16  . UED B 2 .   ? -18.93235 -28.86276 -2.72115  1.000 36.67819 ? 401 UED A H16  1 
HETATM 4637 H H17  . UED B 2 .   ? -18.49743 -30.14608 -1.62902  1.000 36.67819 ? 401 UED A H17  1 
HETATM 4638 H H18  . UED B 2 .   ? -20.00911 -29.30744 -1.42822  1.000 36.67819 ? 401 UED A H18  1 
HETATM 4639 H H19  . UED B 2 .   ? -15.12948 -28.27188 2.52072   1.000 26.45235 ? 401 UED A H19  1 
HETATM 4640 H H20  . UED B 2 .   ? -12.27863 -28.80156 1.70381   1.000 28.81066 ? 401 UED A H20  1 
HETATM 4641 H H21  . UED B 2 .   ? -11.79098 -28.29440 4.10159   1.000 26.71378 ? 401 UED A H21  1 
HETATM 4642 H H22  . UED B 2 .   ? -13.43948 -27.77545 4.32033   1.000 26.71378 ? 401 UED A H22  1 
HETATM 4643 H H23  . UED B 2 .   ? -13.07056 -25.85193 2.69350   1.000 33.66495 ? 401 UED A H23  1 
HETATM 4644 H H24  . UED B 2 .   ? -11.30204 -26.08784 1.20018   1.000 36.07338 ? 401 UED A H24  1 
HETATM 4645 H H25  . UED B 2 .   ? -10.44423 -27.21175 2.22297   1.000 36.07338 ? 401 UED A H25  1 
HETATM 4646 H H26  . UED B 2 .   ? -10.25558 -24.25226 2.13837   1.000 39.28815 ? 401 UED A H26  1 
HETATM 4647 H H27  . UED B 2 .   ? -9.08338  -25.43227 2.73852   1.000 39.28815 ? 401 UED A H27  1 
HETATM 4648 H H28  . UED B 2 .   ? -9.86185  -24.76808 4.81301   1.000 35.55570 ? 401 UED A H28  1 
HETATM 4649 H H31  . UED B 2 .   ? -11.28780 -30.19717 2.97186   1.000 40.08550 ? 401 UED A H31  1 
HETATM 4650 O O    . HOH C 3 .   ? -26.47489 -20.65931 2.81949   1.000 37.42184 ? 501 HOH A O    1 
HETATM 4651 O O    . HOH C 3 .   ? -25.07328 -13.30266 15.57521  1.000 37.66946 ? 502 HOH A O    1 
HETATM 4652 O O    . HOH C 3 .   ? -9.23392  -15.41815 20.98774  1.000 37.44808 ? 503 HOH A O    1 
HETATM 4653 O O    . HOH C 3 .   ? -32.56218 -18.78138 36.05238  1.000 40.96149 ? 504 HOH A O    1 
HETATM 4654 O O    . HOH C 3 .   ? -19.40373 -7.89414  44.74508  1.000 36.31666 ? 505 HOH A O    1 
HETATM 4655 O O    . HOH C 3 .   ? -33.23738 -13.16536 32.84649  1.000 39.13127 ? 506 HOH A O    1 
HETATM 4656 O O    . HOH C 3 .   ? -25.46350 -17.68697 10.62281  1.000 28.82641 ? 507 HOH A O    1 
HETATM 4657 O O    . HOH C 3 .   ? -17.63725 -3.31722  41.48387  1.000 33.36193 ? 508 HOH A O    1 
HETATM 4658 O O    . HOH C 3 .   ? -4.64572  -22.81922 36.77937  1.000 33.28529 ? 509 HOH A O    1 
HETATM 4659 O O    . HOH C 3 .   ? -5.41649  -28.03561 9.97789   1.000 31.59340 ? 510 HOH A O    1 
HETATM 4660 O O    . HOH C 3 .   ? -12.50373 -18.51289 2.55275   1.000 36.08123 ? 511 HOH A O    1 
HETATM 4661 O O    . HOH C 3 .   ? -28.07543 -3.75988  40.31007  1.000 32.25789 ? 512 HOH A O    1 
HETATM 4662 O O    . HOH C 3 .   ? -19.52119 -15.30808 4.06999   1.000 29.98554 ? 513 HOH A O    1 
HETATM 4663 O O    . HOH C 3 .   ? -25.79289 -40.16423 11.67582  1.000 28.64664 ? 514 HOH A O    1 
HETATM 4664 O O    . HOH C 3 .   ? -9.59955  -18.00458 7.78983   1.000 33.26085 ? 515 HOH A O    1 
HETATM 4665 O O    . HOH C 3 .   ? -11.12021 -35.47409 13.91861  1.000 26.32135 ? 516 HOH A O    1 
HETATM 4666 O O    . HOH C 3 .   ? -14.97320 -20.32693 17.13013  1.000 27.60588 ? 517 HOH A O    1 
HETATM 4667 O O    . HOH C 3 .   ? -32.07359 -38.24255 10.05128  1.000 39.77859 ? 518 HOH A O    1 
HETATM 4668 O O    . HOH C 3 .   ? -7.66187  -46.66941 0.49421   1.000 31.97689 ? 519 HOH A O    1 
HETATM 4669 O O    . HOH C 3 .   ? -13.24266 -58.73315 5.27431   1.000 40.82840 ? 520 HOH A O    1 
HETATM 4670 O O    . HOH C 3 .   ? -19.92322 -36.66027 26.89061  1.000 33.81455 ? 521 HOH A O    1 
HETATM 4671 O O    . HOH C 3 .   ? -20.89586 -48.29641 -9.55824  1.000 40.32591 ? 522 HOH A O    1 
HETATM 4672 O O    . HOH C 3 .   ? -21.12672 -39.73840 -9.09366  1.000 38.88818 ? 523 HOH A O    1 
HETATM 4673 O O    . HOH C 3 .   ? -12.12833 -49.98068 1.10948   1.000 26.57311 ? 524 HOH A O    1 
HETATM 4674 O O    . HOH C 3 .   ? -14.69685 -50.33571 -0.87770  1.000 31.34581 ? 525 HOH A O    1 
HETATM 4675 O O    . HOH C 3 .   ? -19.99150 -52.71016 -4.82495  1.000 30.26880 ? 526 HOH A O    1 
HETATM 4676 O O    . HOH C 3 .   ? -19.88068 -32.18046 22.38001  1.000 31.17816 ? 527 HOH A O    1 
HETATM 4677 O O    . HOH C 3 .   ? -7.65327  -35.81180 3.68340   1.000 28.38088 ? 528 HOH A O    1 
HETATM 4678 O O    . HOH C 3 .   ? -26.07805 -4.82819  41.79129  1.000 27.88343 ? 529 HOH A O    1 
HETATM 4679 O O    . HOH C 3 .   ? -11.43376 -18.21987 10.70406  1.000 32.85948 ? 530 HOH A O    1 
HETATM 4680 O O    . HOH C 3 .   ? -15.95224 -4.23733  39.67638  1.000 36.22647 ? 531 HOH A O    1 
HETATM 4681 O O    . HOH C 3 .   ? -28.63265 -25.20645 6.68690   1.000 32.73037 ? 532 HOH A O    1 
HETATM 4682 O O    . HOH C 3 .   ? -30.85175 -6.26742  37.23421  1.000 39.20963 ? 533 HOH A O    1 
HETATM 4683 O O    . HOH C 3 .   ? -10.43125 -44.72970 20.52300  1.000 33.50030 ? 534 HOH A O    1 
HETATM 4684 O O    . HOH C 3 .   ? -18.30811 -14.76604 8.85225   1.000 36.47534 ? 535 HOH A O    1 
HETATM 4685 O O    . HOH C 3 .   ? -21.72795 -20.15267 26.88841  1.000 27.32676 ? 536 HOH A O    1 
HETATM 4686 O O    . HOH C 3 .   ? -27.34834 -17.69196 18.26506  1.000 30.63676 ? 537 HOH A O    1 
HETATM 4687 O O    . HOH C 3 .   ? -13.36559 -44.65546 -5.95794  1.000 33.11082 ? 538 HOH A O    1 
HETATM 4688 O O    . HOH C 3 .   ? -3.70868  -22.78755 23.91154  1.000 32.87615 ? 539 HOH A O    1 
HETATM 4689 O O    . HOH C 3 .   ? -15.40283 -27.74297 25.67050  1.000 34.70180 ? 540 HOH A O    1 
HETATM 4690 O O    . HOH C 3 .   ? -14.53769 -12.98750 20.20918  1.000 38.14826 ? 541 HOH A O    1 
HETATM 4691 O O    . HOH C 3 .   ? -19.95752 0.34753   35.08804  1.000 33.69366 ? 542 HOH A O    1 
HETATM 4692 O O    . HOH C 3 .   ? -21.52754 1.52749   43.41700  1.000 34.63673 ? 543 HOH A O    1 
HETATM 4693 O O    . HOH C 3 .   ? -18.05460 -26.03333 28.17784  1.000 39.00235 ? 544 HOH A O    1 
HETATM 4694 O O    . HOH C 3 .   ? -2.59386  -22.68278 41.84162  1.000 32.16889 ? 545 HOH A O    1 
HETATM 4695 O O    . HOH C 3 .   ? -9.49814  -19.06442 12.46602  1.000 31.59434 ? 546 HOH A O    1 
HETATM 4696 O O    . HOH C 3 .   ? -22.27805 0.98632   36.33013  1.000 38.69862 ? 547 HOH A O    1 
HETATM 4697 O O    . HOH C 3 .   ? -17.26543 -54.15738 -0.93220  1.000 36.66429 ? 548 HOH A O    1 
HETATM 4698 O O    . HOH C 3 .   ? -20.66919 -32.41629 2.32612   1.000 21.87273 ? 549 HOH A O    1 
HETATM 4699 O O    . HOH C 3 .   ? -12.47689 -14.46632 21.65327  1.000 36.59563 ? 550 HOH A O    1 
HETATM 4700 O O    . HOH C 3 .   ? -9.06668  -44.48975 1.29186   1.000 26.80341 ? 551 HOH A O    1 
HETATM 4701 O O    . HOH C 3 .   ? -24.85093 -50.50695 12.46843  1.000 45.17099 ? 552 HOH A O    1 
HETATM 4702 O O    . HOH C 3 .   ? -21.88872 -46.17447 14.65879  1.000 29.09568 ? 553 HOH A O    1 
HETATM 4703 O O    . HOH C 3 .   ? -28.18630 -27.63434 4.54463   1.000 27.44660 ? 554 HOH A O    1 
HETATM 4704 O O    . HOH C 3 .   ? -21.67312 -24.47789 10.95209  1.000 21.28686 ? 555 HOH A O    1 
HETATM 4705 O O    . HOH C 3 .   ? -32.76019 -34.15394 9.34387   1.000 39.93489 ? 556 HOH A O    1 
HETATM 4706 O O    . HOH C 3 .   ? -29.74950 -35.98309 2.03902   1.000 31.54672 ? 557 HOH A O    1 
HETATM 4707 O O    . HOH C 3 .   ? -6.56279  -25.63407 1.31294   1.000 33.65196 ? 558 HOH A O    1 
HETATM 4708 O O    . HOH C 3 .   ? -20.46556 -14.29630 6.54181   1.000 38.22234 ? 559 HOH A O    1 
HETATM 4709 O O    . HOH C 3 .   ? -25.25262 -16.17384 40.38242  1.000 35.28148 ? 560 HOH A O    1 
HETATM 4710 O O    . HOH C 3 .   ? -28.77162 -24.22962 12.88089  1.000 32.84298 ? 561 HOH A O    1 
HETATM 4711 O O    . HOH C 3 .   ? -24.17446 -34.71824 16.54162  1.000 28.23864 ? 562 HOH A O    1 
HETATM 4712 O O    . HOH C 3 .   ? -9.03811  -49.00540 14.89610  1.000 35.25388 ? 563 HOH A O    1 
HETATM 4713 O O    . HOH C 3 .   ? -25.99698 -45.47376 -4.64303  1.000 31.49544 ? 564 HOH A O    1 
HETATM 4714 O O    . HOH C 3 .   ? -13.03983 -51.38229 -3.47091  1.000 26.98736 ? 565 HOH A O    1 
HETATM 4715 O O    . HOH C 3 .   ? -18.46304 -15.57894 11.58867  1.000 26.66745 ? 566 HOH A O    1 
HETATM 4716 O O    . HOH C 3 .   ? -28.29073 -29.27316 6.76822   1.000 24.97569 ? 567 HOH A O    1 
HETATM 4717 O O    . HOH C 3 .   ? -1.05152  -39.09314 19.67866  1.000 32.17475 ? 568 HOH A O    1 
HETATM 4718 O O    . HOH C 3 .   ? -20.66521 -55.11919 10.25464  1.000 34.02073 ? 569 HOH A O    1 
HETATM 4719 O O    . HOH C 3 .   ? -27.01777 -28.80085 2.14201   1.000 29.81017 ? 570 HOH A O    1 
HETATM 4720 O O    . HOH C 3 .   ? -33.77719 -11.99556 36.99747  1.000 40.70285 ? 571 HOH A O    1 
HETATM 4721 O O    . HOH C 3 .   ? -12.50374 -6.93794  22.87966  1.000 33.07560 ? 572 HOH A O    1 
HETATM 4722 O O    . HOH C 3 .   ? -30.610   -21.785   36.811    1.000 35.13731 ? 573 HOH A O    1 
HETATM 4723 O O    . HOH C 3 .   ? -14.23535 -16.31708 27.34647  1.000 26.77493 ? 574 HOH A O    1 
HETATM 4724 O O    . HOH C 3 .   ? -12.75997 -23.55909 26.01871  1.000 32.53309 ? 575 HOH A O    1 
HETATM 4725 O O    . HOH C 3 .   ? -15.27812 -6.99189  22.84954  1.000 34.36675 ? 576 HOH A O    1 
HETATM 4726 O O    . HOH C 3 .   ? -20.86818 -23.52487 30.81321  1.000 34.64696 ? 577 HOH A O    1 
HETATM 4727 O O    . HOH C 3 .   ? -29.33918 -25.28068 15.52106  1.000 37.13976 ? 578 HOH A O    1 
HETATM 4728 O O    . HOH C 3 .   ? -15.47672 -1.96024  23.16219  1.000 40.24008 ? 579 HOH A O    1 
HETATM 4729 O O    . HOH C 3 .   ? -28.08282 -33.06544 21.41109  1.000 37.81332 ? 580 HOH A O    1 
HETATM 4730 O O    . HOH C 3 .   ? -24.39203 -14.43160 26.93455  1.000 32.25486 ? 581 HOH A O    1 
HETATM 4731 O O    . HOH C 3 .   ? -22.74336 -22.81734 -9.33994  1.000 39.19101 ? 582 HOH A O    1 
HETATM 4732 O O    . HOH C 3 .   ? -24.94803 -21.17054 40.68847  1.000 31.45447 ? 583 HOH A O    1 
HETATM 4733 O O    . HOH C 3 .   ? -29.02926 -41.12415 -4.42221  1.000 38.24668 ? 584 HOH A O    1 
HETATM 4734 O O    . HOH C 3 .   ? -23.30337 -50.95165 -3.91342  1.000 28.92385 ? 585 HOH A O    1 
HETATM 4735 O O    . HOH C 3 .   ? -27.94507 -25.48356 17.99814  1.000 37.13900 ? 586 HOH A O    1 
HETATM 4736 O O    . HOH C 3 .   ? -20.84627 -25.71875 29.17018  1.000 38.26178 ? 587 HOH A O    1 
HETATM 4737 O O    . HOH C 3 .   ? -14.61886 -44.89337 26.28408  1.000 40.25891 ? 588 HOH A O    1 
HETATM 4738 O O    . HOH C 3 .   ? -10.19622 -24.15866 27.26837  1.000 31.04190 ? 589 HOH A O    1 
HETATM 4739 O O    . HOH C 3 .   ? -27.74194 -33.88365 -12.00163 1.000 38.74435 ? 590 HOH A O    1 
HETATM 4740 O O    . HOH C 3 .   ? -10.97691 -25.07637 30.12098  1.000 34.30324 ? 591 HOH A O    1 
HETATM 4741 O O    . HOH C 3 .   ? -19.38034 5.25162   22.00533  1.000 42.80480 ? 592 HOH A O    1 
HETATM 4742 O O    . HOH C 3 .   ? -19.08702 -26.75013 25.97863  1.000 37.12736 ? 593 HOH A O    1 
HETATM 4743 O O    . HOH C 3 .   ? -19.07480 -37.49103 -9.27656  1.000 43.00296 ? 594 HOH A O    1 
HETATM 4744 O O    . HOH C 3 .   ? -6.77997  -24.93263 21.97061  1.000 25.60273 ? 595 HOH A O    1 
HETATM 4745 O O    . HOH C 3 .   ? -29.06453 -43.15349 0.55412   1.000 39.52132 ? 596 HOH A O    1 
HETATM 4746 O O    . HOH C 3 .   ? -13.35139 -1.63704  34.22547  1.000 39.84746 ? 597 HOH A O    1 
HETATM 4747 O O    . HOH C 3 .   ? -24.31860 -32.91434 -9.95187  1.000 36.00261 ? 598 HOH A O    1 
HETATM 4748 O O    . HOH C 3 .   ? -26.63796 -18.17035 4.23568   1.000 33.60860 ? 599 HOH A O    1 
HETATM 4749 O O    . HOH C 3 .   ? -21.12871 -54.81751 -1.64882  1.000 32.31618 ? 600 HOH A O    1 
HETATM 4750 O O    . HOH C 3 .   ? -6.27178  -43.82777 9.87056   1.000 34.52723 ? 601 HOH A O    1 
HETATM 4751 O O    . HOH C 3 .   ? -13.89934 2.51277   40.58586  1.000 38.21459 ? 602 HOH A O    1 
HETATM 4752 O O    . HOH C 3 .   ? -26.29080 -40.66418 20.36953  1.000 30.64901 ? 603 HOH A O    1 
HETATM 4753 O O    . HOH C 3 .   ? -25.63157 -47.13645 5.55782   1.000 34.91557 ? 604 HOH A O    1 
HETATM 4754 O O    . HOH C 3 .   ? -26.31975 -50.06138 0.71960   1.000 35.17344 ? 605 HOH A O    1 
HETATM 4755 O O    . HOH C 3 .   ? -4.04457  -19.54323 25.27134  1.000 37.13589 ? 606 HOH A O    1 
HETATM 4756 O O    . HOH C 3 .   ? -29.59523 -10.60545 38.08753  1.000 38.70524 ? 607 HOH A O    1 
HETATM 4757 O O    . HOH C 3 .   ? -23.40007 4.91613   29.72715  1.000 53.78123 ? 608 HOH A O    1 
HETATM 4758 O O    . HOH C 3 .   ? -2.44120  -17.30294 32.56065  1.000 34.94059 ? 609 HOH A O    1 
HETATM 4759 O O    . HOH C 3 .   ? -17.39361 -10.96616 18.31281  1.000 39.34832 ? 610 HOH A O    1 
HETATM 4760 O O    . HOH C 3 .   ? -15.09758 -52.56339 -0.19275  1.000 25.31911 ? 611 HOH A O    1 
HETATM 4761 O O    . HOH C 3 .   ? -4.89360  -43.79535 6.56367   1.000 38.24915 ? 612 HOH A O    1 
HETATM 4762 O O    . HOH C 3 .   ? -28.37103 -31.97190 -4.03505  1.000 33.74553 ? 613 HOH A O    1 
HETATM 4763 O O    . HOH C 3 .   ? -29.87445 -41.09677 13.09602  1.000 38.81205 ? 614 HOH A O    1 
HETATM 4764 O O    . HOH C 3 .   ? -32.90059 -4.97003  35.35484  1.000 40.36000 ? 615 HOH A O    1 
HETATM 4765 O O    . HOH C 3 .   ? -4.87045  -10.02766 22.22049  0.50  27.25077 ? 616 HOH A O    1 
HETATM 4766 O O    . HOH C 3 .   ? -16.99971 -56.71338 -0.56109  1.000 33.18277 ? 617 HOH A O    1 
HETATM 4767 O O    . HOH C 3 .   ? -31.64985 -35.97545 11.39881  1.000 40.05018 ? 618 HOH A O    1 
HETATM 4768 O O    . HOH C 3 .   ? -4.078    -5.304    46.579    1.000 46.94651 ? 619 HOH A O    1 
HETATM 4769 O O    . HOH C 3 .   ? -21.44196 -45.93393 23.26912  1.000 36.64377 ? 620 HOH A O    1 
HETATM 4770 O O    . HOH C 3 .   ? -16.21054 -38.78101 -8.50276  1.000 39.40709 ? 621 HOH A O    1 
HETATM 4771 O O    . HOH C 3 .   ? -6.98708  -15.78282 27.64015  1.000 36.72449 ? 622 HOH A O    1 
HETATM 4772 O O    . HOH C 3 .   ? -14.38592 -46.60979 -10.07262 1.000 40.45613 ? 623 HOH A O    1 
HETATM 4773 O O    . HOH C 3 .   ? -1.42550  1.83267   30.63825  1.000 41.93973 ? 624 HOH A O    1 
HETATM 4774 O O    . HOH C 3 .   ? -29.11863 -12.92504 40.63183  1.000 31.08964 ? 625 HOH A O    1 
HETATM 4775 O O    . HOH C 3 .   ? -22.41833 -22.01267 29.04719  1.000 36.32612 ? 626 HOH A O    1 
HETATM 4776 O O    . HOH C 3 .   ? -10.60885 -39.56597 31.86071  1.000 40.49018 ? 627 HOH A O    1 
HETATM 4777 O O    . HOH C 3 .   ? -4.87045  -26.57094 22.22049  0.50  31.15531 ? 628 HOH A O    1 
HETATM 4778 O O    . HOH C 3 .   ? -2.99092  -28.38952 10.21969  1.000 38.05150 ? 629 HOH A O    1 
HETATM 4779 O O    . HOH C 3 .   ? -7.14980  -47.02991 14.04593  1.000 43.10543 ? 630 HOH A O    1 
HETATM 4780 O O    . HOH C 3 .   ? -21.61494 -31.51324 24.57070  1.000 37.76515 ? 631 HOH A O    1 
HETATM 4781 O O    . HOH C 3 .   ? -27.44438 -44.57144 -1.56346  1.000 33.06116 ? 632 HOH A O    1 
HETATM 4782 O O    . HOH C 3 .   ? -6.23786  -46.44827 -1.40499  1.000 45.29089 ? 633 HOH A O    1 
HETATM 4783 O O    . HOH C 3 .   ? -25.06258 -16.83111 25.05031  1.000 41.57613 ? 634 HOH A O    1 
HETATM 4784 O O    . HOH C 3 .   ? -26.79904 -35.19470 16.85364  1.000 35.58551 ? 635 HOH A O    1 
HETATM 4785 O O    . HOH C 3 .   ? -13.16450 -60.08964 7.45487   1.000 43.96626 ? 636 HOH A O    1 
HETATM 4786 O O    . HOH C 3 .   ? -22.58266 -40.85340 27.99670  1.000 45.23979 ? 637 HOH A O    1 
HETATM 4787 O O    . HOH C 3 .   ? -28.75235 -28.69828 -0.14350  1.000 36.89719 ? 638 HOH A O    1 
HETATM 4788 O O    . HOH C 3 .   ? -24.32624 -19.26297 26.16393  1.000 38.66293 ? 639 HOH A O    1 
HETATM 4789 O O    . HOH C 3 .   ? -32.10033 -12.99401 41.41061  1.000 43.67617 ? 640 HOH A O    1 
HETATM 4790 O O    . HOH C 3 .   ? -33.49839 -2.99926  36.83630  1.000 38.79835 ? 641 HOH A O    1 
HETATM 4791 O O    . HOH C 3 .   ? -27.04850 -41.54692 13.60013  1.000 37.33163 ? 642 HOH A O    1 
HETATM 4792 O O    . HOH C 3 .   ? -25.58641 -50.93933 -2.64143  1.000 38.20888 ? 643 HOH A O    1 
HETATM 4793 O O    . HOH C 3 .   ? -28.07145 -43.86453 -3.89664  1.000 36.84568 ? 644 HOH A O    1 
HETATM 4794 O O    . HOH C 3 .   ? -25.503   -18.847   -7.799    1.000 41.59652 ? 645 HOH A O    1 
HETATM 4795 O O    . HOH C 3 .   ? -27.79794 -18.27690 12.00875  1.000 32.09683 ? 646 HOH A O    1 
HETATM 4796 O O    . HOH C 3 .   ? 1.828     -35.398   14.114    1.000 39.94642 ? 647 HOH A O    1 
HETATM 4797 O O    . HOH C 3 .   ? -18.966   -54.712   -2.990    1.000 30.43296 ? 648 HOH A O    1 
HETATM 4798 O O    . HOH C 3 .   ? -12.11336 -36.08362 33.80637  1.000 43.03065 ? 649 HOH A O    1 
HETATM 4799 O O    . HOH C 3 .   ? -30.63026 -26.87224 4.43403   1.000 37.08275 ? 650 HOH A O    1 
HETATM 4800 O O    . HOH C 3 .   ? -22.73621 -53.14138 -5.20479  1.000 33.64378 ? 651 HOH A O    1 
HETATM 4801 O O    . HOH C 3 .   ? 0.00412   -0.43534  31.46765  1.000 35.68202 ? 652 HOH A O    1 
HETATM 4802 O O    . HOH C 3 .   ? -29.67883 -41.17874 -1.16442  1.000 36.27920 ? 653 HOH A O    1 
HETATM 4803 O O    . HOH C 3 .   ? -18.70770 -58.25123 1.01852   1.000 35.82921 ? 654 HOH A O    1 
HETATM 4804 O O    . HOH C 3 .   ? -17.94289 -60.70752 2.01138   1.000 43.55850 ? 655 HOH A O    1 
HETATM 4805 O O    . HOH C 3 .   ? -28.03984 -10.70508 40.30629  1.000 39.60139 ? 656 HOH A O    1 
HETATM 4806 O O    . HOH C 3 .   ? -14.30678 5.48364   40.81172  1.000 47.50894 ? 657 HOH A O    1 
HETATM 4807 O O    . HOH C 3 .   ? -15.66958 -4.18834  22.01750  1.000 37.12199 ? 658 HOH A O    1 
HETATM 4808 O O    . HOH C 3 .   ? -30.88762 -5.62257  40.11173  1.000 42.07379 ? 659 HOH A O    1 
# 
