data_9BOA
# 
_entry.id   9BOA 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BOA         pdb_00009boa 10.2210/pdb9boa/pdb 
WWPDB D_1000283734 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-12 ? 
2 'Structure model' 1 1 2025-03-12 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
_pdbx_audit_revision_category.ordinal             1 
_pdbx_audit_revision_category.revision_ordinal    2 
_pdbx_audit_revision_category.data_content_type   'Structure model' 
_pdbx_audit_revision_category.category            citation 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
5 2 'Structure model' '_citation.title'                   
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BOA 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-03 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              karen.anderson@yale.edu 
_pdbx_contact_author.name_first         Karen 
_pdbx_contact_author.name_last          Anderson 
_pdbx_contact_author.name_mi            S 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-3433-0780 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Papini, C.'     1 0000-0002-6098-4959 
'Kenneson, J.'   2 ?                   
'Anderson, K.S.' 3 0000-0003-3433-0780 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Acs Bio Med Chem Au' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2694-2437 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            5 
_citation.language                  ? 
_citation.page_first                215 
_citation.page_last                 226 
_citation.title                     
'Exploring Possible Drug-Resistant Variants of SARS-CoV-2 Main Protease (M pro ) with Noncovalent Preclinical Candidate, Mpro61.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acsbiomedchemau.4c00109 
_citation.pdbx_database_id_PubMed   39990941 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Kenneson, J.R.'  1 ? 
primary 'Papini, C.'      2 ? 
primary 'Tang, S.'        3 ? 
primary 'Huynh, K.'       4 ? 
primary 'Zhang, C.H.'     5 ? 
primary 'Jorgensen, W.L.' 6 ? 
primary 'Anderson, K.S.'  7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '3C-like proteinase nsp5'                                                                              33853.598 
1   3.4.22.69 ? ? ? 
2 non-polymer syn 'N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide' 405.488   
1   ?         ? ? ? 
3 water       nat water                                                                                                  18.015    
146 ?         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHVGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHVGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide' UED 
3 water                                                                                                  HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   GLY n 
1 3   PHE n 
1 4   ARG n 
1 5   LYS n 
1 6   MET n 
1 7   ALA n 
1 8   PHE n 
1 9   PRO n 
1 10  SER n 
1 11  GLY n 
1 12  LYS n 
1 13  VAL n 
1 14  GLU n 
1 15  GLY n 
1 16  CYS n 
1 17  MET n 
1 18  VAL n 
1 19  GLN n 
1 20  VAL n 
1 21  THR n 
1 22  CYS n 
1 23  GLY n 
1 24  THR n 
1 25  THR n 
1 26  THR n 
1 27  LEU n 
1 28  ASN n 
1 29  GLY n 
1 30  LEU n 
1 31  TRP n 
1 32  LEU n 
1 33  ASP n 
1 34  ASP n 
1 35  VAL n 
1 36  VAL n 
1 37  TYR n 
1 38  CYS n 
1 39  PRO n 
1 40  ARG n 
1 41  HIS n 
1 42  VAL n 
1 43  ILE n 
1 44  CYS n 
1 45  THR n 
1 46  SER n 
1 47  GLU n 
1 48  ASP n 
1 49  MET n 
1 50  LEU n 
1 51  ASN n 
1 52  PRO n 
1 53  ASN n 
1 54  TYR n 
1 55  GLU n 
1 56  ASP n 
1 57  LEU n 
1 58  LEU n 
1 59  ILE n 
1 60  ARG n 
1 61  LYS n 
1 62  SER n 
1 63  ASN n 
1 64  HIS n 
1 65  ASN n 
1 66  PHE n 
1 67  LEU n 
1 68  VAL n 
1 69  GLN n 
1 70  ALA n 
1 71  GLY n 
1 72  ASN n 
1 73  VAL n 
1 74  GLN n 
1 75  LEU n 
1 76  ARG n 
1 77  VAL n 
1 78  ILE n 
1 79  GLY n 
1 80  HIS n 
1 81  SER n 
1 82  MET n 
1 83  GLN n 
1 84  ASN n 
1 85  CYS n 
1 86  VAL n 
1 87  LEU n 
1 88  LYS n 
1 89  LEU n 
1 90  LYS n 
1 91  VAL n 
1 92  ASP n 
1 93  THR n 
1 94  ALA n 
1 95  ASN n 
1 96  PRO n 
1 97  LYS n 
1 98  THR n 
1 99  PRO n 
1 100 LYS n 
1 101 TYR n 
1 102 LYS n 
1 103 PHE n 
1 104 VAL n 
1 105 ARG n 
1 106 ILE n 
1 107 GLN n 
1 108 PRO n 
1 109 GLY n 
1 110 GLN n 
1 111 THR n 
1 112 PHE n 
1 113 SER n 
1 114 VAL n 
1 115 LEU n 
1 116 ALA n 
1 117 CYS n 
1 118 TYR n 
1 119 ASN n 
1 120 GLY n 
1 121 SER n 
1 122 PRO n 
1 123 SER n 
1 124 GLY n 
1 125 VAL n 
1 126 TYR n 
1 127 GLN n 
1 128 CYS n 
1 129 ALA n 
1 130 MET n 
1 131 ARG n 
1 132 PRO n 
1 133 ASN n 
1 134 PHE n 
1 135 THR n 
1 136 ILE n 
1 137 LYS n 
1 138 GLY n 
1 139 SER n 
1 140 PHE n 
1 141 LEU n 
1 142 ASN n 
1 143 GLY n 
1 144 SER n 
1 145 CYS n 
1 146 GLY n 
1 147 SER n 
1 148 VAL n 
1 149 GLY n 
1 150 PHE n 
1 151 ASN n 
1 152 ILE n 
1 153 ASP n 
1 154 TYR n 
1 155 ASP n 
1 156 CYS n 
1 157 VAL n 
1 158 SER n 
1 159 PHE n 
1 160 CYS n 
1 161 TYR n 
1 162 MET n 
1 163 HIS n 
1 164 HIS n 
1 165 MET n 
1 166 GLU n 
1 167 LEU n 
1 168 PRO n 
1 169 THR n 
1 170 GLY n 
1 171 VAL n 
1 172 HIS n 
1 173 VAL n 
1 174 GLY n 
1 175 THR n 
1 176 ASP n 
1 177 LEU n 
1 178 GLU n 
1 179 GLY n 
1 180 ASN n 
1 181 PHE n 
1 182 TYR n 
1 183 GLY n 
1 184 PRO n 
1 185 PHE n 
1 186 VAL n 
1 187 ASP n 
1 188 ARG n 
1 189 GLN n 
1 190 THR n 
1 191 ALA n 
1 192 GLN n 
1 193 ALA n 
1 194 ALA n 
1 195 GLY n 
1 196 THR n 
1 197 ASP n 
1 198 THR n 
1 199 THR n 
1 200 ILE n 
1 201 THR n 
1 202 VAL n 
1 203 ASN n 
1 204 VAL n 
1 205 LEU n 
1 206 ALA n 
1 207 TRP n 
1 208 LEU n 
1 209 TYR n 
1 210 ALA n 
1 211 ALA n 
1 212 VAL n 
1 213 ILE n 
1 214 ASN n 
1 215 GLY n 
1 216 ASP n 
1 217 ARG n 
1 218 TRP n 
1 219 PHE n 
1 220 LEU n 
1 221 ASN n 
1 222 ARG n 
1 223 PHE n 
1 224 THR n 
1 225 THR n 
1 226 THR n 
1 227 LEU n 
1 228 ASN n 
1 229 ASP n 
1 230 PHE n 
1 231 ASN n 
1 232 LEU n 
1 233 VAL n 
1 234 ALA n 
1 235 MET n 
1 236 LYS n 
1 237 TYR n 
1 238 ASN n 
1 239 TYR n 
1 240 GLU n 
1 241 PRO n 
1 242 LEU n 
1 243 THR n 
1 244 GLN n 
1 245 ASP n 
1 246 HIS n 
1 247 VAL n 
1 248 ASP n 
1 249 ILE n 
1 250 LEU n 
1 251 GLY n 
1 252 PRO n 
1 253 LEU n 
1 254 SER n 
1 255 ALA n 
1 256 GLN n 
1 257 THR n 
1 258 GLY n 
1 259 ILE n 
1 260 ALA n 
1 261 VAL n 
1 262 LEU n 
1 263 ASP n 
1 264 MET n 
1 265 CYS n 
1 266 ALA n 
1 267 SER n 
1 268 LEU n 
1 269 LYS n 
1 270 GLU n 
1 271 LEU n 
1 272 LEU n 
1 273 GLN n 
1 274 ASN n 
1 275 GLY n 
1 276 MET n 
1 277 ASN n 
1 278 GLY n 
1 279 ARG n 
1 280 THR n 
1 281 ILE n 
1 282 LEU n 
1 283 GLY n 
1 284 SER n 
1 285 ALA n 
1 286 LEU n 
1 287 LEU n 
1 288 GLU n 
1 289 ASP n 
1 290 GLU n 
1 291 PHE n 
1 292 THR n 
1 293 PRO n 
1 294 PHE n 
1 295 ASP n 
1 296 VAL n 
1 297 VAL n 
1 298 ARG n 
1 299 GLN n 
1 300 CYS n 
1 301 SER n 
1 302 GLY n 
1 303 VAL n 
1 304 THR n 
1 305 PHE n 
1 306 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   306 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'rep, 1a-1b' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                                                                                ? 
'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                                                                               ? 
'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                                                                             ? 
'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                                                                        ? 
'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE                                                                                               ? 
'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE                                                                                              ? 
'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                                                                        ? 
'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                                                                                ? 
'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                                                                                              ? 
'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                                                                                  ? 
'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                                                                             ? 
'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                                                                                ? 
'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                                                                                 ? 
'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                                                                                             ? 
'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE                                                                                          ? 
'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                                                                                                ? 
'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                                                                                 ? 
'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                                                                                              ? 
'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                                                                             ? 
'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                                                                               ? 
'C9 H11 N O3'    181.189 
UED non-polymer         . 'N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide' 
'GC373 bound form, GC376 bound form' 'C21 H31 N3 O5'  405.488 
VAL 'L-peptide linking' y VALINE                                                                                                 ? 
'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   1   1   SER SER A . n 
A 1 2   GLY 2   2   2   GLY GLY A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   ARG 4   4   4   ARG ARG A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   MET 6   6   6   MET MET A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   PRO 9   9   9   PRO PRO A . n 
A 1 10  SER 10  10  10  SER SER A . n 
A 1 11  GLY 11  11  11  GLY GLY A . n 
A 1 12  LYS 12  12  12  LYS LYS A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  GLY 15  15  15  GLY GLY A . n 
A 1 16  CYS 16  16  16  CYS CYS A . n 
A 1 17  MET 17  17  17  MET MET A . n 
A 1 18  VAL 18  18  18  VAL VAL A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  THR 21  21  21  THR THR A . n 
A 1 22  CYS 22  22  22  CYS CYS A . n 
A 1 23  GLY 23  23  23  GLY GLY A . n 
A 1 24  THR 24  24  24  THR THR A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  THR 26  26  26  THR THR A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  ASN 28  28  28  ASN ASN A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  TRP 31  31  31  TRP TRP A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  ASP 33  33  33  ASP ASP A . n 
A 1 34  ASP 34  34  34  ASP ASP A . n 
A 1 35  VAL 35  35  35  VAL VAL A . n 
A 1 36  VAL 36  36  36  VAL VAL A . n 
A 1 37  TYR 37  37  37  TYR TYR A . n 
A 1 38  CYS 38  38  38  CYS CYS A . n 
A 1 39  PRO 39  39  39  PRO PRO A . n 
A 1 40  ARG 40  40  40  ARG ARG A . n 
A 1 41  HIS 41  41  41  HIS HIS A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  ILE 43  43  43  ILE ILE A . n 
A 1 44  CYS 44  44  44  CYS CYS A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  SER 46  46  46  SER SER A . n 
A 1 47  GLU 47  47  47  GLU GLU A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  MET 49  49  49  MET MET A . n 
A 1 50  LEU 50  50  50  LEU LEU A . n 
A 1 51  ASN 51  51  51  ASN ASN A . n 
A 1 52  PRO 52  52  52  PRO PRO A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  TYR 54  54  54  TYR TYR A . n 
A 1 55  GLU 55  55  55  GLU GLU A . n 
A 1 56  ASP 56  56  56  ASP ASP A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  ILE 59  59  59  ILE ILE A . n 
A 1 60  ARG 60  60  60  ARG ARG A . n 
A 1 61  LYS 61  61  61  LYS LYS A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  ASN 63  63  63  ASN ASN A . n 
A 1 64  HIS 64  64  64  HIS HIS A . n 
A 1 65  ASN 65  65  65  ASN ASN A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  GLN 69  69  69  GLN GLN A . n 
A 1 70  ALA 70  70  70  ALA ALA A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  ASN 72  72  72  ASN ASN A . n 
A 1 73  VAL 73  73  73  VAL VAL A . n 
A 1 74  GLN 74  74  74  GLN GLN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  ARG 76  76  76  ARG ARG A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  GLY 79  79  79  GLY GLY A . n 
A 1 80  HIS 80  80  80  HIS HIS A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  MET 82  82  82  MET MET A . n 
A 1 83  GLN 83  83  83  GLN GLN A . n 
A 1 84  ASN 84  84  84  ASN ASN A . n 
A 1 85  CYS 85  85  85  CYS CYS A . n 
A 1 86  VAL 86  86  86  VAL VAL A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  LYS 88  88  88  LYS LYS A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  LYS 90  90  90  LYS LYS A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  ASP 92  92  92  ASP ASP A . n 
A 1 93  THR 93  93  93  THR THR A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  PRO 96  96  96  PRO PRO A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  PRO 99  99  99  PRO PRO A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 TYR 101 101 101 TYR TYR A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 PHE 103 103 103 PHE PHE A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 ARG 105 105 105 ARG ARG A . n 
A 1 106 ILE 106 106 106 ILE ILE A . n 
A 1 107 GLN 107 107 107 GLN GLN A . n 
A 1 108 PRO 108 108 108 PRO PRO A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 GLN 110 110 110 GLN GLN A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 PHE 112 112 112 PHE PHE A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 CYS 117 117 117 CYS CYS A . n 
A 1 118 TYR 118 118 118 TYR TYR A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 SER 123 123 123 SER SER A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 MET 130 130 130 MET MET A . n 
A 1 131 ARG 131 131 131 ARG ARG A . n 
A 1 132 PRO 132 132 132 PRO PRO A . n 
A 1 133 ASN 133 133 133 ASN ASN A . n 
A 1 134 PHE 134 134 134 PHE PHE A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 LYS 137 137 137 LYS LYS A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 PHE 140 140 140 PHE PHE A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 ASN 142 142 142 ASN ASN A . n 
A 1 143 GLY 143 143 143 GLY GLY A . n 
A 1 144 SER 144 144 144 SER SER A . n 
A 1 145 CYS 145 145 145 CYS CYS A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 GLY 149 149 149 GLY GLY A . n 
A 1 150 PHE 150 150 150 PHE PHE A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 ILE 152 152 152 ILE ILE A . n 
A 1 153 ASP 153 153 153 ASP ASP A . n 
A 1 154 TYR 154 154 154 TYR TYR A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 CYS 156 156 156 CYS CYS A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 SER 158 158 158 SER SER A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 CYS 160 160 160 CYS CYS A . n 
A 1 161 TYR 161 161 161 TYR TYR A . n 
A 1 162 MET 162 162 162 MET MET A . n 
A 1 163 HIS 163 163 163 HIS HIS A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 MET 165 165 165 MET MET A . n 
A 1 166 GLU 166 166 166 GLU GLU A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 PRO 168 168 168 PRO PRO A . n 
A 1 169 THR 169 169 169 THR THR A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 VAL 171 171 171 VAL VAL A . n 
A 1 172 HIS 172 172 172 HIS HIS A . n 
A 1 173 VAL 173 173 173 VAL VAL A . n 
A 1 174 GLY 174 174 174 GLY GLY A . n 
A 1 175 THR 175 175 175 THR THR A . n 
A 1 176 ASP 176 176 176 ASP ASP A . n 
A 1 177 LEU 177 177 177 LEU LEU A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 TYR 182 182 182 TYR TYR A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 VAL 186 186 186 VAL VAL A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 GLN 189 189 189 GLN GLN A . n 
A 1 190 THR 190 190 190 THR THR A . n 
A 1 191 ALA 191 191 191 ALA ALA A . n 
A 1 192 GLN 192 192 192 GLN GLN A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 THR 196 196 196 THR THR A . n 
A 1 197 ASP 197 197 197 ASP ASP A . n 
A 1 198 THR 198 198 198 THR THR A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 ILE 200 200 200 ILE ILE A . n 
A 1 201 THR 201 201 201 THR THR A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 ALA 206 206 206 ALA ALA A . n 
A 1 207 TRP 207 207 207 TRP TRP A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ALA 210 210 210 ALA ALA A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ASN 214 214 214 ASN ASN A . n 
A 1 215 GLY 215 215 215 GLY GLY A . n 
A 1 216 ASP 216 216 216 ASP ASP A . n 
A 1 217 ARG 217 217 217 ARG ARG A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 ASN 221 221 221 ASN ASN A . n 
A 1 222 ARG 222 222 222 ARG ARG A . n 
A 1 223 PHE 223 223 223 PHE PHE A . n 
A 1 224 THR 224 224 224 THR THR A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 THR 226 226 226 THR THR A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 ASN 228 228 228 ASN ASN A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 PHE 230 230 230 PHE PHE A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 VAL 233 233 233 VAL VAL A . n 
A 1 234 ALA 234 234 234 ALA ALA A . n 
A 1 235 MET 235 235 235 MET MET A . n 
A 1 236 LYS 236 236 236 LYS LYS A . n 
A 1 237 TYR 237 237 237 TYR TYR A . n 
A 1 238 ASN 238 238 238 ASN ASN A . n 
A 1 239 TYR 239 239 239 TYR TYR A . n 
A 1 240 GLU 240 240 240 GLU GLU A . n 
A 1 241 PRO 241 241 241 PRO PRO A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 THR 243 243 243 THR THR A . n 
A 1 244 GLN 244 244 244 GLN GLN A . n 
A 1 245 ASP 245 245 245 ASP ASP A . n 
A 1 246 HIS 246 246 246 HIS HIS A . n 
A 1 247 VAL 247 247 247 VAL VAL A . n 
A 1 248 ASP 248 248 248 ASP ASP A . n 
A 1 249 ILE 249 249 249 ILE ILE A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 PRO 252 252 252 PRO PRO A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 SER 254 254 254 SER SER A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 THR 257 257 257 THR THR A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 ILE 259 259 259 ILE ILE A . n 
A 1 260 ALA 260 260 260 ALA ALA A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 LEU 262 262 262 LEU LEU A . n 
A 1 263 ASP 263 263 263 ASP ASP A . n 
A 1 264 MET 264 264 264 MET MET A . n 
A 1 265 CYS 265 265 265 CYS CYS A . n 
A 1 266 ALA 266 266 266 ALA ALA A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 LYS 269 269 269 LYS LYS A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 LEU 271 271 271 LEU LEU A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 ASN 274 274 274 ASN ASN A . n 
A 1 275 GLY 275 275 275 GLY GLY A . n 
A 1 276 MET 276 276 276 MET MET A . n 
A 1 277 ASN 277 277 277 ASN ASN A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 ARG 279 279 279 ARG ARG A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 ILE 281 281 281 ILE ILE A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 GLY 283 283 283 GLY GLY A . n 
A 1 284 SER 284 284 284 SER SER A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 LEU 286 286 286 LEU LEU A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 ASP 289 289 289 ASP ASP A . n 
A 1 290 GLU 290 290 290 GLU GLU A . n 
A 1 291 PHE 291 291 291 PHE PHE A . n 
A 1 292 THR 292 292 292 THR THR A . n 
A 1 293 PRO 293 293 293 PRO PRO A . n 
A 1 294 PHE 294 294 294 PHE PHE A . n 
A 1 295 ASP 295 295 295 ASP ASP A . n 
A 1 296 VAL 296 296 296 VAL VAL A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 GLN 299 299 299 GLN GLN A . n 
A 1 300 CYS 300 300 300 CYS CYS A . n 
A 1 301 SER 301 301 301 SER SER A . n 
A 1 302 GLY 302 302 302 GLY GLY A . n 
A 1 303 VAL 303 303 ?   ?   ?   A . n 
A 1 304 THR 304 304 ?   ?   ?   A . n 
A 1 305 PHE 305 305 ?   ?   ?   A . n 
A 1 306 GLN 306 306 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        UED 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   UED 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 UED 1   401 999 UED GCA A . 
C 3 HOH 1   501 5   HOH HOH A . 
C 3 HOH 2   502 13  HOH HOH A . 
C 3 HOH 3   503 147 HOH HOH A . 
C 3 HOH 4   504 101 HOH HOH A . 
C 3 HOH 5   505 2   HOH HOH A . 
C 3 HOH 6   506 149 HOH HOH A . 
C 3 HOH 7   507 105 HOH HOH A . 
C 3 HOH 8   508 10  HOH HOH A . 
C 3 HOH 9   509 62  HOH HOH A . 
C 3 HOH 10  510 72  HOH HOH A . 
C 3 HOH 11  511 112 HOH HOH A . 
C 3 HOH 12  512 29  HOH HOH A . 
C 3 HOH 13  513 132 HOH HOH A . 
C 3 HOH 14  514 131 HOH HOH A . 
C 3 HOH 15  515 104 HOH HOH A . 
C 3 HOH 16  516 71  HOH HOH A . 
C 3 HOH 17  517 65  HOH HOH A . 
C 3 HOH 18  518 16  HOH HOH A . 
C 3 HOH 19  519 86  HOH HOH A . 
C 3 HOH 20  520 125 HOH HOH A . 
C 3 HOH 21  521 97  HOH HOH A . 
C 3 HOH 22  522 26  HOH HOH A . 
C 3 HOH 23  523 98  HOH HOH A . 
C 3 HOH 24  524 88  HOH HOH A . 
C 3 HOH 25  525 45  HOH HOH A . 
C 3 HOH 26  526 49  HOH HOH A . 
C 3 HOH 27  527 95  HOH HOH A . 
C 3 HOH 28  528 121 HOH HOH A . 
C 3 HOH 29  529 9   HOH HOH A . 
C 3 HOH 30  530 138 HOH HOH A . 
C 3 HOH 31  531 77  HOH HOH A . 
C 3 HOH 32  532 52  HOH HOH A . 
C 3 HOH 33  533 67  HOH HOH A . 
C 3 HOH 34  534 153 HOH HOH A . 
C 3 HOH 35  535 21  HOH HOH A . 
C 3 HOH 36  536 36  HOH HOH A . 
C 3 HOH 37  537 116 HOH HOH A . 
C 3 HOH 38  538 50  HOH HOH A . 
C 3 HOH 39  539 117 HOH HOH A . 
C 3 HOH 40  540 66  HOH HOH A . 
C 3 HOH 41  541 89  HOH HOH A . 
C 3 HOH 42  542 33  HOH HOH A . 
C 3 HOH 43  543 123 HOH HOH A . 
C 3 HOH 44  544 25  HOH HOH A . 
C 3 HOH 45  545 103 HOH HOH A . 
C 3 HOH 46  546 28  HOH HOH A . 
C 3 HOH 47  547 39  HOH HOH A . 
C 3 HOH 48  548 102 HOH HOH A . 
C 3 HOH 49  549 70  HOH HOH A . 
C 3 HOH 50  550 46  HOH HOH A . 
C 3 HOH 51  551 3   HOH HOH A . 
C 3 HOH 52  552 11  HOH HOH A . 
C 3 HOH 53  553 133 HOH HOH A . 
C 3 HOH 54  554 76  HOH HOH A . 
C 3 HOH 55  555 118 HOH HOH A . 
C 3 HOH 56  556 19  HOH HOH A . 
C 3 HOH 57  557 55  HOH HOH A . 
C 3 HOH 58  558 4   HOH HOH A . 
C 3 HOH 59  559 96  HOH HOH A . 
C 3 HOH 60  560 87  HOH HOH A . 
C 3 HOH 61  561 69  HOH HOH A . 
C 3 HOH 62  562 27  HOH HOH A . 
C 3 HOH 63  563 60  HOH HOH A . 
C 3 HOH 64  564 32  HOH HOH A . 
C 3 HOH 65  565 8   HOH HOH A . 
C 3 HOH 66  566 43  HOH HOH A . 
C 3 HOH 67  567 108 HOH HOH A . 
C 3 HOH 68  568 106 HOH HOH A . 
C 3 HOH 69  569 44  HOH HOH A . 
C 3 HOH 70  570 91  HOH HOH A . 
C 3 HOH 71  571 80  HOH HOH A . 
C 3 HOH 72  572 20  HOH HOH A . 
C 3 HOH 73  573 139 HOH HOH A . 
C 3 HOH 74  574 1   HOH HOH A . 
C 3 HOH 75  575 93  HOH HOH A . 
C 3 HOH 76  576 84  HOH HOH A . 
C 3 HOH 77  577 63  HOH HOH A . 
C 3 HOH 78  578 17  HOH HOH A . 
C 3 HOH 79  579 140 HOH HOH A . 
C 3 HOH 80  580 22  HOH HOH A . 
C 3 HOH 81  581 68  HOH HOH A . 
C 3 HOH 82  582 12  HOH HOH A . 
C 3 HOH 83  583 6   HOH HOH A . 
C 3 HOH 84  584 23  HOH HOH A . 
C 3 HOH 85  585 114 HOH HOH A . 
C 3 HOH 86  586 38  HOH HOH A . 
C 3 HOH 87  587 107 HOH HOH A . 
C 3 HOH 88  588 64  HOH HOH A . 
C 3 HOH 89  589 30  HOH HOH A . 
C 3 HOH 90  590 79  HOH HOH A . 
C 3 HOH 91  591 99  HOH HOH A . 
C 3 HOH 92  592 145 HOH HOH A . 
C 3 HOH 93  593 42  HOH HOH A . 
C 3 HOH 94  594 31  HOH HOH A . 
C 3 HOH 95  595 126 HOH HOH A . 
C 3 HOH 96  596 58  HOH HOH A . 
C 3 HOH 97  597 51  HOH HOH A . 
C 3 HOH 98  598 142 HOH HOH A . 
C 3 HOH 99  599 151 HOH HOH A . 
C 3 HOH 100 600 78  HOH HOH A . 
C 3 HOH 101 601 41  HOH HOH A . 
C 3 HOH 102 602 122 HOH HOH A . 
C 3 HOH 103 603 92  HOH HOH A . 
C 3 HOH 104 604 47  HOH HOH A . 
C 3 HOH 105 605 14  HOH HOH A . 
C 3 HOH 106 606 37  HOH HOH A . 
C 3 HOH 107 607 127 HOH HOH A . 
C 3 HOH 108 608 100 HOH HOH A . 
C 3 HOH 109 609 40  HOH HOH A . 
C 3 HOH 110 610 24  HOH HOH A . 
C 3 HOH 111 611 18  HOH HOH A . 
C 3 HOH 112 612 35  HOH HOH A . 
C 3 HOH 113 613 54  HOH HOH A . 
C 3 HOH 114 614 143 HOH HOH A . 
C 3 HOH 115 615 56  HOH HOH A . 
C 3 HOH 116 616 75  HOH HOH A . 
C 3 HOH 117 617 148 HOH HOH A . 
C 3 HOH 118 618 73  HOH HOH A . 
C 3 HOH 119 619 53  HOH HOH A . 
C 3 HOH 120 620 136 HOH HOH A . 
C 3 HOH 121 621 83  HOH HOH A . 
C 3 HOH 122 622 57  HOH HOH A . 
C 3 HOH 123 623 134 HOH HOH A . 
C 3 HOH 124 624 15  HOH HOH A . 
C 3 HOH 125 625 146 HOH HOH A . 
C 3 HOH 126 626 135 HOH HOH A . 
C 3 HOH 127 627 61  HOH HOH A . 
C 3 HOH 128 628 141 HOH HOH A . 
C 3 HOH 129 629 85  HOH HOH A . 
C 3 HOH 130 630 82  HOH HOH A . 
C 3 HOH 131 631 150 HOH HOH A . 
C 3 HOH 132 632 119 HOH HOH A . 
C 3 HOH 133 633 81  HOH HOH A . 
C 3 HOH 134 634 90  HOH HOH A . 
C 3 HOH 135 635 109 HOH HOH A . 
C 3 HOH 136 636 115 HOH HOH A . 
C 3 HOH 137 637 113 HOH HOH A . 
C 3 HOH 138 638 74  HOH HOH A . 
C 3 HOH 139 639 94  HOH HOH A . 
C 3 HOH 140 640 129 HOH HOH A . 
C 3 HOH 141 641 110 HOH HOH A . 
C 3 HOH 142 642 137 HOH HOH A . 
C 3 HOH 143 643 7   HOH HOH A . 
C 3 HOH 144 644 59  HOH HOH A . 
C 3 HOH 145 645 152 HOH HOH A . 
C 3 HOH 146 646 120 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A LEU 50  ? CG  ? A LEU 50  CG  
2  1 Y 1 A LEU 50  ? CD1 ? A LEU 50  CD1 
3  1 Y 1 A LEU 50  ? CD2 ? A LEU 50  CD2 
4  1 Y 1 A ASN 72  ? CG  ? A ASN 72  CG  
5  1 Y 1 A ASN 72  ? OD1 ? A ASN 72  OD1 
6  1 Y 1 A ASN 72  ? ND2 ? A ASN 72  ND2 
7  1 Y 1 A ARG 188 ? CG  ? A ARG 188 CG  
8  1 Y 1 A ARG 188 ? CD  ? A ARG 188 CD  
9  1 Y 1 A ARG 188 ? NE  ? A ARG 188 NE  
10 1 Y 1 A ARG 188 ? CZ  ? A ARG 188 CZ  
11 1 Y 1 A ARG 188 ? NH1 ? A ARG 188 NH1 
12 1 Y 1 A ARG 188 ? NH2 ? A ARG 188 NH2 
13 1 Y 1 A ARG 217 ? CG  ? A ARG 217 CG  
14 1 Y 1 A ARG 217 ? CD  ? A ARG 217 CD  
15 1 Y 1 A ARG 217 ? NE  ? A ARG 217 NE  
16 1 Y 1 A ARG 217 ? CZ  ? A ARG 217 CZ  
17 1 Y 1 A ARG 217 ? NH1 ? A ARG 217 NH1 
18 1 Y 1 A ARG 217 ? NH2 ? A ARG 217 NH2 
19 1 Y 1 A ARG 222 ? CG  ? A ARG 222 CG  
20 1 Y 1 A ARG 222 ? CD  ? A ARG 222 CD  
21 1 Y 1 A ARG 222 ? NE  ? A ARG 222 NE  
22 1 Y 1 A ARG 222 ? CZ  ? A ARG 222 CZ  
23 1 Y 1 A ARG 222 ? NH1 ? A ARG 222 NH1 
24 1 Y 1 A ARG 222 ? NH2 ? A ARG 222 NH2 
25 1 Y 1 A ASP 229 ? CG  ? A ASP 229 CG  
26 1 Y 1 A ASP 229 ? OD1 ? A ASP 229 OD1 
27 1 Y 1 A ASP 229 ? OD2 ? A ASP 229 OD2 
28 1 Y 1 A MET 235 ? CG  ? A MET 235 CG  
29 1 Y 1 A MET 235 ? SD  ? A MET 235 SD  
30 1 Y 1 A MET 235 ? CE  ? A MET 235 CE  
31 1 Y 1 A LYS 236 ? CG  ? A LYS 236 CG  
32 1 Y 1 A LYS 236 ? CD  ? A LYS 236 CD  
33 1 Y 1 A LYS 236 ? CE  ? A LYS 236 CE  
34 1 Y 1 A LYS 236 ? NZ  ? A LYS 236 NZ  
35 1 Y 1 A ARG 279 ? CG  ? A ARG 279 CG  
36 1 Y 1 A ARG 279 ? CD  ? A ARG 279 CD  
37 1 Y 1 A ARG 279 ? NE  ? A ARG 279 NE  
38 1 Y 1 A ARG 279 ? CZ  ? A ARG 279 CZ  
39 1 Y 1 A ARG 279 ? NH1 ? A ARG 279 NH1 
40 1 Y 1 A ARG 279 ? NH2 ? A ARG 279 NH2 
41 1 Y 1 A PHE 294 ? CG  ? A PHE 294 CG  
42 1 Y 1 A PHE 294 ? CD1 ? A PHE 294 CD1 
43 1 Y 1 A PHE 294 ? CD2 ? A PHE 294 CD2 
44 1 Y 1 A PHE 294 ? CE1 ? A PHE 294 CE1 
45 1 Y 1 A PHE 294 ? CE2 ? A PHE 294 CE2 
46 1 Y 1 A PHE 294 ? CZ  ? A PHE 294 CZ  
47 1 Y 1 A ARG 298 ? CG  ? A ARG 298 CG  
48 1 Y 1 A ARG 298 ? CD  ? A ARG 298 CD  
49 1 Y 1 A ARG 298 ? NE  ? A ARG 298 NE  
50 1 Y 1 A ARG 298 ? CZ  ? A ARG 298 CZ  
51 1 Y 1 A ARG 298 ? NH1 ? A ARG 298 NH1 
52 1 Y 1 A ARG 298 ? NH2 ? A ARG 298 NH2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   102.262 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BOA 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     114.265 
_cell.length_a_esd                 ? 
_cell.length_b                     53.460 
_cell.length_b_esd                 ? 
_cell.length_c                     45.626 
_cell.length_c_esd                 ? 
_cell.volume                       272352.959 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BOA 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y' 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BOA 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.01 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          38.84 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              9.0 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '10% v/v Polyethylene glycol 200, 0.1 M BIS-TRIS propane, 18% w/v Polyethylene glycol 8,000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            294 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-01-25 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.920126 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSLS-II BEAMLINE 17-ID-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.920126 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   17-ID-1 
_diffrn_source.pdbx_synchrotron_site       NSLS-II 
# 
_reflns.B_iso_Wilson_estimate                          32.24 
_reflns.entry_id                                       9BOA 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.7 
_reflns.d_resolution_low                               31.33 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     29326 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           98.19 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                7.0 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          9.84 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.996 
_reflns.pdbx_CC_star                                   0.999 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.08844 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.7 
_reflns_shell.d_res_low                                     1.76 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           0.92 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2833 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               6.5 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.462 
_reflns_shell.pdbx_CC_star                                  0.795 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          95.39 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.409 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               39.82 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9BOA 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.70 
_refine.ls_d_res_low                             31.33 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     29326 
_refine.ls_number_reflns_R_free                  1440 
_refine.ls_number_reflns_R_work                  27886 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.18 
_refine.ls_percent_reflns_R_free                 4.91 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1938 
_refine.ls_R_factor_R_free                       0.2400 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1913 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 28.5178 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2207 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.70 
_refine_hist.d_res_low                        31.33 
_refine_hist.number_atoms_solvent             146 
_refine_hist.number_atoms_total               2458 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2283 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         29 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0107  ? 2378 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.1596  ? 3243 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0633  ? 370  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0088  ? 423  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 13.3119 ? 828  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.70 1.76  . . 141 2704 95.12 . . . . 0.2990 . . . . . . . . . . . 0.3346 
'X-RAY DIFFRACTION' 1.76 1.83  . . 135 2726 97.61 . . . . 0.2833 . . . . . . . . . . . 0.3260 
'X-RAY DIFFRACTION' 1.83 1.91  . . 147 2791 97.90 . . . . 0.2577 . . . . . . . . . . . 0.2930 
'X-RAY DIFFRACTION' 1.91 2.01  . . 152 2741 98.00 . . . . 0.2321 . . . . . . . . . . . 0.2907 
'X-RAY DIFFRACTION' 2.01 2.14  . . 139 2777 98.35 . . . . 0.2194 . . . . . . . . . . . 0.2958 
'X-RAY DIFFRACTION' 2.14 2.30  . . 133 2788 98.48 . . . . 0.2177 . . . . . . . . . . . 0.2452 
'X-RAY DIFFRACTION' 2.30 2.53  . . 149 2824 98.87 . . . . 0.2179 . . . . . . . . . . . 0.2987 
'X-RAY DIFFRACTION' 2.53 2.90  . . 134 2813 98.99 . . . . 0.2068 . . . . . . . . . . . 0.2733 
'X-RAY DIFFRACTION' 2.90 3.65  . . 155 2833 99.24 . . . . 0.1847 . . . . . . . . . . . 0.2546 
'X-RAY DIFFRACTION' 3.65 31.33 . . 155 2889 99.19 . . . . 0.1561 . . . . . . . . . . . 0.1871 
# 
_struct.entry_id                     9BOA 
_struct.title                        'Crystal Structure of A173V SARS-CoV-2 Main Protease in Complex with GC376' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BOA 
_struct_keywords.text            'Hydrolase, VIRAL PROTEIN' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1AB_SARS2 
_struct_ref.pdbx_db_accession          P0DTD1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_struct_ref.pdbx_align_begin           3264 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9BOA 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 306 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P0DTD1 
_struct_ref_seq.db_align_beg                  3264 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3569 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       306 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             9BOA 
_struct_ref_seq_dif.mon_id                       VAL 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      173 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   P0DTD1 
_struct_ref_seq_dif.db_mon_id                    ALA 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          3436 
_struct_ref_seq_dif.details                      'engineered mutation' 
_struct_ref_seq_dif.pdbx_auth_seq_num            173 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2680  ? 
1 MORE         -15   ? 
1 'SSA (A^2)'  24480 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z     1.0000000000  0.0000000000 0.0000000000 0.0000000000  0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000  
2 'crystal symmetry operation' 2_556 -x,y,-z+1 -1.0000000000 0.0000000000 0.0000000000 -9.6901565675 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 44.5851179397 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 10  ? GLY A 15  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 41  ? CYS A 44  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 GLU A 47  ? ASN A 51  ? GLU A 47  ASN A 51  5 ? 5  
HELX_P HELX_P4  AA4 ASN A 53  ? ARG A 60  ? ASN A 53  ARG A 60  1 ? 8  
HELX_P HELX_P5  AA5 LYS A 61  ? PHE A 66  ? LYS A 61  PHE A 66  5 ? 6  
HELX_P HELX_P6  AA6 ILE A 200 ? ASN A 214 ? ILE A 200 ASN A 214 1 ? 15 
HELX_P HELX_P7  AA7 THR A 226 ? TYR A 237 ? THR A 226 TYR A 237 1 ? 12 
HELX_P HELX_P8  AA8 THR A 243 ? GLY A 258 ? THR A 243 GLY A 258 1 ? 16 
HELX_P HELX_P9  AA9 ALA A 260 ? GLY A 275 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P10 AB1 THR A 292 ? SER A 301 ? THR A 292 SER A 301 1 ? 10 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            covale1 
_struct_conn.conn_type_id                  covale 
_struct_conn.pdbx_leaving_atom_flag        one 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            145 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           B 
_struct_conn.ptnr2_label_comp_id           UED 
_struct_conn.ptnr2_label_seq_id            . 
_struct_conn.ptnr2_label_atom_id           C21 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             145 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            UED 
_struct_conn.ptnr2_auth_seq_id             401 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               1.771 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      UED 
_pdbx_modification_feature.label_asym_id                      B 
_pdbx_modification_feature.label_seq_id                       . 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      145 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       UED 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        401 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       145 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               C21 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                CYS 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        UED 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Covalent chemical modification' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 73  ? LEU A 75  ? VAL A 73  LEU A 75  
AA1 2 LEU A 67  ? ALA A 70  ? LEU A 67  ALA A 70  
AA1 3 MET A 17  ? CYS A 22  ? MET A 17  CYS A 22  
AA1 4 THR A 25  ? LEU A 32  ? THR A 25  LEU A 32  
AA1 5 VAL A 35  ? PRO A 39  ? VAL A 35  PRO A 39  
AA1 6 VAL A 86  ? VAL A 91  ? VAL A 86  VAL A 91  
AA1 7 VAL A 77  ? GLN A 83  ? VAL A 77  GLN A 83  
AA2 1 LYS A 100 ? PHE A 103 ? LYS A 100 PHE A 103 
AA2 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA2 3 VAL A 148 ? ASP A 153 ? VAL A 148 ASP A 153 
AA2 4 THR A 111 ? TYR A 118 ? THR A 111 TYR A 118 
AA2 5 SER A 121 ? ALA A 129 ? SER A 121 ALA A 129 
AA3 1 LYS A 100 ? PHE A 103 ? LYS A 100 PHE A 103 
AA3 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA3 3 HIS A 172 ? THR A 175 ? HIS A 172 THR A 175 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL A 73  ? O VAL A 73  N ALA A 70  ? N ALA A 70  
AA1 2 3 O LEU A 67  ? O LEU A 67  N THR A 21  ? N THR A 21  
AA1 3 4 N VAL A 20  ? N VAL A 20  O LEU A 27  ? O LEU A 27  
AA1 4 5 N LEU A 30  ? N LEU A 30  O TYR A 37  ? O TYR A 37  
AA1 5 6 N CYS A 38  ? N CYS A 38  O LEU A 87  ? O LEU A 87  
AA1 6 7 O VAL A 86  ? O VAL A 86  N GLN A 83  ? N GLN A 83  
AA2 1 2 N LYS A 100 ? N LYS A 100 O VAL A 157 ? O VAL A 157 
AA2 2 3 O SER A 158 ? O SER A 158 N ASN A 151 ? N ASN A 151 
AA2 3 4 O PHE A 150 ? O PHE A 150 N SER A 113 ? N SER A 113 
AA2 4 5 N ALA A 116 ? N ALA A 116 O SER A 123 ? O SER A 123 
AA3 1 2 N LYS A 100 ? N LYS A 100 O VAL A 157 ? O VAL A 157 
AA3 2 3 N MET A 165 ? N MET A 165 O VAL A 173 ? O VAL A 173 
# 
_pdbx_entry_details.entry_id                   9BOA 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 33  ? ? 49.87   -137.77 
2 1 ASN A 51  ? ? -159.24 69.93   
3 1 ASN A 84  ? ? 53.62   -124.54 
4 1 TYR A 154 ? ? 46.32   -93.23  
5 1 PRO A 184 ? ? -86.64  38.50   
# 
_pdbx_molecule_features.prd_id    PRD_002495 
_pdbx_molecule_features.name      GC376 
_pdbx_molecule_features.type      Peptide-like 
_pdbx_molecule_features.class     Inhibitor 
_pdbx_molecule_features.details   ? 
# 
_pdbx_molecule.instance_id   1 
_pdbx_molecule.prd_id        PRD_002495 
_pdbx_molecule.asym_id       B 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 605 ? C HOH . 
2 1 A HOH 610 ? C HOH . 
3 1 A HOH 643 ? C HOH . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 -x,y,-z         
3 x+1/2,y+1/2,z   
4 -x+1/2,y+1/2,-z 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A VAL 303 ? A VAL 303 
2 1 Y 1 A THR 304 ? A THR 304 
3 1 Y 1 A PHE 305 ? A PHE 305 
4 1 Y 1 A GLN 306 ? A GLN 306 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
UED C7   C N N 372 
UED O8   O N N 373 
UED C9   C N N 374 
UED O10  O N N 375 
UED C1   C Y N 376 
UED C2   C Y N 377 
UED C3   C Y N 378 
UED C4   C Y N 379 
UED C5   C Y N 380 
UED C6   C Y N 381 
UED N11  N N N 382 
UED C12  C N S 383 
UED C17  C N N 384 
UED O18  O N N 385 
UED C13  C N N 386 
UED C14  C N N 387 
UED C15  C N N 388 
UED C16  C N N 389 
UED N19  N N N 390 
UED C20  C N S 391 
UED C21  C N N 392 
UED O22  O N N 393 
UED C24  C N N 394 
UED C25  C N S 395 
UED C26  C N N 396 
UED C27  C N N 397 
UED N28  N N N 398 
UED C29  C N N 399 
UED O30  O N N 400 
UED H1   H N N 401 
UED H2   H N N 402 
UED H3   H N N 403 
UED H4   H N N 404 
UED H5   H N N 405 
UED H6   H N N 406 
UED H7   H N N 407 
UED H8   H N N 408 
UED H9   H N N 409 
UED H10  H N N 410 
UED H11  H N N 411 
UED H12  H N N 412 
UED H13  H N N 413 
UED H14  H N N 414 
UED H15  H N N 415 
UED H16  H N N 416 
UED H17  H N N 417 
UED H18  H N N 418 
UED H19  H N N 419 
UED H20  H N N 420 
UED H21  H N N 421 
UED H22  H N N 422 
UED H23  H N N 423 
UED H24  H N N 424 
UED H25  H N N 425 
UED H26  H N N 426 
UED H27  H N N 427 
UED H28  H N N 428 
UED H29  H N N 429 
UED H30  H N N 430 
UED H31  H N N 431 
VAL N    N N N 432 
VAL CA   C N S 433 
VAL C    C N N 434 
VAL O    O N N 435 
VAL CB   C N N 436 
VAL CG1  C N N 437 
VAL CG2  C N N 438 
VAL OXT  O N N 439 
VAL H    H N N 440 
VAL H2   H N N 441 
VAL HA   H N N 442 
VAL HB   H N N 443 
VAL HG11 H N N 444 
VAL HG12 H N N 445 
VAL HG13 H N N 446 
VAL HG21 H N N 447 
VAL HG22 H N N 448 
VAL HG23 H N N 449 
VAL HXT  H N N 450 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
UED C16 C14  sing N N 358 
UED C3  C2   doub Y N 359 
UED C3  C4   sing Y N 360 
UED C2  C1   sing Y N 361 
UED C14 C13  sing N N 362 
UED C14 C15  sing N N 363 
UED C13 C12  sing N N 364 
UED C4  C5   doub Y N 365 
UED O8  C7   sing N N 366 
UED O8  C9   sing N N 367 
UED N11 C12  sing N N 368 
UED N11 C9   sing N N 369 
UED C1  C7   sing N N 370 
UED C1  C6   doub Y N 371 
UED O18 C17  doub N N 372 
UED C5  C6   sing Y N 373 
UED C12 C17  sing N N 374 
UED C9  O10  doub N N 375 
UED C17 N19  sing N N 376 
UED C26 C27  sing N N 377 
UED C26 C25  sing N N 378 
UED N19 C20  sing N N 379 
UED C20 C21  sing N N 380 
UED C20 C24  sing N N 381 
UED C27 N28  sing N N 382 
UED O22 C21  sing N N 383 
UED C25 C24  sing N N 384 
UED C25 C29  sing N N 385 
UED N28 C29  sing N N 386 
UED C29 O30  doub N N 387 
UED C7  H1   sing N N 388 
UED C7  H2   sing N N 389 
UED C2  H3   sing N N 390 
UED C3  H4   sing N N 391 
UED C4  H5   sing N N 392 
UED C5  H6   sing N N 393 
UED C6  H7   sing N N 394 
UED N11 H8   sing N N 395 
UED C12 H9   sing N N 396 
UED C13 H10  sing N N 397 
UED C13 H11  sing N N 398 
UED C14 H12  sing N N 399 
UED C15 H13  sing N N 400 
UED C15 H14  sing N N 401 
UED C15 H15  sing N N 402 
UED C16 H16  sing N N 403 
UED C16 H17  sing N N 404 
UED C16 H18  sing N N 405 
UED N19 H19  sing N N 406 
UED C20 H20  sing N N 407 
UED C24 H21  sing N N 408 
UED C24 H22  sing N N 409 
UED C25 H23  sing N N 410 
UED C26 H24  sing N N 411 
UED C26 H25  sing N N 412 
UED C27 H26  sing N N 413 
UED C27 H27  sing N N 414 
UED N28 H28  sing N N 415 
UED C21 H29  sing N N 416 
UED C21 H30  sing N N 417 
UED O22 H31  sing N N 418 
VAL N   CA   sing N N 419 
VAL N   H    sing N N 420 
VAL N   H2   sing N N 421 
VAL CA  C    sing N N 422 
VAL CA  CB   sing N N 423 
VAL CA  HA   sing N N 424 
VAL C   O    doub N N 425 
VAL C   OXT  sing N N 426 
VAL CB  CG1  sing N N 427 
VAL CB  CG2  sing N N 428 
VAL CB  HB   sing N N 429 
VAL CG1 HG11 sing N N 430 
VAL CG1 HG12 sing N N 431 
VAL CG1 HG13 sing N N 432 
VAL CG2 HG21 sing N N 433 
VAL CG2 HG22 sing N N 434 
VAL CG2 HG23 sing N N 435 
VAL OXT HXT  sing N N 436 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' 'P30 GM133893' 1 
'Department of Energy (DOE, United States)'                                                'United States' KP1607011      2 
'Other government'                                                                         ?               DE-SC0012704   3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7NF5 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'C 1 2 1' 
_space_group.name_Hall        'C 2y' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9BOA 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.008752 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.001902 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.018706 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.022429 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . SER A 1 1   ? -1.87971  -22.25734 39.24671  1.000 34.03006  ? 1   SER A N    1 
ATOM   2    C CA   . SER A 1 1   ? -2.68564  -21.20045 38.59509  1.000 34.17006  ? 1   SER A CA   1 
ATOM   3    C C    . SER A 1 1   ? -2.34638  -21.12527 37.12529  1.000 36.59814  ? 1   SER A C    1 
ATOM   4    O O    . SER A 1 1   ? -1.55103  -21.92821 36.62230  1.000 31.41484  ? 1   SER A O    1 
ATOM   5    C CB   . SER A 1 1   ? -2.43883  -19.83425 39.24976  1.000 41.24354  ? 1   SER A CB   1 
ATOM   6    O OG   . SER A 1 1   ? -1.20411  -19.28524 38.84482  1.000 40.90394  ? 1   SER A OG   1 
ATOM   7    H H1   . SER A 1 1   ? -2.31103  -23.03407 39.19424  1.000 40.89018  ? 1   SER A H1   1 
ATOM   8    H H2   . SER A 1 1   ? -1.09322  -22.32637 38.83590  1.000 40.89018  ? 1   SER A H2   1 
ATOM   9    H H3   . SER A 1 1   ? -1.75035  -22.04698 40.10177  1.000 40.89018  ? 1   SER A H3   1 
ATOM   10   H HA   . SER A 1 1   ? -3.62706  -21.41046 38.69766  1.000 41.05817  ? 1   SER A HA   1 
ATOM   11   H HB2  . SER A 1 1   ? -3.15118  -19.22905 38.99055  1.000 49.54635  ? 1   SER A HB2  1 
ATOM   12   H HB3  . SER A 1 1   ? -2.43180  -19.94499 40.21339  1.000 49.54635  ? 1   SER A HB3  1 
ATOM   13   H HG   . SER A 1 1   ? -1.05442  -18.57360 39.26526  1.000 49.13883  ? 1   SER A HG   1 
ATOM   14   N N    . GLY A 1 2   ? -2.93294  -20.15203 36.44479  1.000 34.14578  ? 2   GLY A N    1 
ATOM   15   C CA   . GLY A 1 2   ? -2.77220  -19.93430 35.02111  1.000 36.68844  ? 2   GLY A CA   1 
ATOM   16   C C    . GLY A 1 2   ? -4.03794  -20.35746 34.29231  1.000 33.93955  ? 2   GLY A C    1 
ATOM   17   O O    . GLY A 1 2   ? -4.81080  -21.19434 34.78024  1.000 37.84667  ? 2   GLY A O    1 
ATOM   18   H H    . GLY A 1 2   ? -3.45714  -19.57401 36.80633  1.000 41.02904  ? 2   GLY A H    1 
ATOM   19   H HA2  . GLY A 1 2   ? -2.60460  -18.99508 34.84598  1.000 44.08023  ? 2   GLY A HA2  1 
ATOM   20   H HA3  . GLY A 1 2   ? -2.02527  -20.45585 34.68799  1.000 44.08023  ? 2   GLY A HA3  1 
ATOM   21   N N    . PHE A 1 3   ? -4.26440  -19.75625 33.13433  1.000 30.01829  ? 3   PHE A N    1 
ATOM   22   C CA   . PHE A 1 3   ? -5.48045  -20.03127 32.37068  1.000 30.49685  ? 3   PHE A CA   1 
ATOM   23   C C    . PHE A 1 3   ? -5.13479  -20.08206 30.90301  1.000 29.80722  ? 3   PHE A C    1 
ATOM   24   O O    . PHE A 1 3   ? -4.58189  -19.12583 30.36206  1.000 35.99431  ? 3   PHE A O    1 
ATOM   25   C CB   . PHE A 1 3   ? -6.56133  -18.97410 32.63539  1.000 35.76736  ? 3   PHE A CB   1 
ATOM   26   C CG   . PHE A 1 3   ? -7.93061  -19.38938 32.16432  1.000 36.55112  ? 3   PHE A CG   1 
ATOM   27   C CD1  . PHE A 1 3   ? -8.68712  -20.30086 32.89748  1.000 42.39107  ? 3   PHE A CD1  1 
ATOM   28   C CD2  . PHE A 1 3   ? -8.45990  -18.86943 30.99947  1.000 35.28136  ? 3   PHE A CD2  1 
ATOM   29   C CE1  . PHE A 1 3   ? -9.95675  -20.69058 32.46047  1.000 44.86370  ? 3   PHE A CE1  1 
ATOM   30   C CE2  . PHE A 1 3   ? -9.71660  -19.26043 30.55891  1.000 38.33887  ? 3   PHE A CE2  1 
ATOM   31   C CZ   . PHE A 1 3   ? -10.46876 -20.15179 31.29282  1.000 39.95370  ? 3   PHE A CZ   1 
ATOM   32   H H    . PHE A 1 3   ? -3.73364  -19.18708 32.76835  1.000 36.07605  ? 3   PHE A H    1 
ATOM   33   H HA   . PHE A 1 3   ? -5.83106  -20.89719 32.63174  1.000 36.65032  ? 3   PHE A HA   1 
ATOM   34   H HB2  . PHE A 1 3   ? -6.61197  -18.80978 33.59003  1.000 42.97493  ? 3   PHE A HB2  1 
ATOM   35   H HB3  . PHE A 1 3   ? -6.32147  -18.15730 32.17041  1.000 42.97493  ? 3   PHE A HB3  1 
ATOM   36   H HD1  . PHE A 1 3   ? -8.34384  -20.65405 33.68635  1.000 50.92339  ? 3   PHE A HD1  1 
ATOM   37   H HD2  . PHE A 1 3   ? -7.96996  -18.25192 30.50598  1.000 42.39174  ? 3   PHE A HD2  1 
ATOM   38   H HE1  . PHE A 1 3   ? -10.45284 -21.30635 32.94998  1.000 53.89054  ? 3   PHE A HE1  1 
ATOM   39   H HE2  . PHE A 1 3   ? -10.05356 -18.91832 29.76247  1.000 46.06074  ? 3   PHE A HE2  1 
ATOM   40   H HZ   . PHE A 1 3   ? -11.31969 -20.39115 31.00382  1.000 47.99854  ? 3   PHE A HZ   1 
ATOM   41   N N    . ARG A 1 4   ? -5.42256  -21.20688 30.25711  1.000 32.29738  ? 4   ARG A N    1 
ATOM   42   C CA   . ARG A 1 4   ? -4.98699  -21.45311 28.88816  1.000 29.28102  ? 4   ARG A CA   1 
ATOM   43   C C    . ARG A 1 4   ? -6.13232  -22.08198 28.12358  1.000 29.92753  ? 4   ARG A C    1 
ATOM   44   O O    . ARG A 1 4   ? -6.93324  -22.82805 28.68443  1.000 34.50071  ? 4   ARG A O    1 
ATOM   45   C CB   . ARG A 1 4   ? -3.79371  -22.40352 28.83321  1.000 31.00500  ? 4   ARG A CB   1 
ATOM   46   C CG   . ARG A 1 4   ? -2.47850  -21.83228 29.33188  1.000 34.95559  ? 4   ARG A CG   1 
ATOM   47   C CD   . ARG A 1 4   ? -2.00836  -20.67490 28.46575  1.000 35.65045  ? 4   ARG A CD   1 
ATOM   48   N NE   . ARG A 1 4   ? -2.02198  -21.08997 27.07525  1.000 30.00685  ? 4   ARG A NE   1 
ATOM   49   C CZ   . ARG A 1 4   ? -1.14966  -21.91579 26.52780  1.000 33.11485  ? 4   ARG A CZ   1 
ATOM   50   N NH1  . ARG A 1 4   ? -0.09058  -22.34001 27.19762  1.000 40.37485  ? 4   ARG A NH1  1 
ATOM   51   N NH2  . ARG A 1 4   ? -1.36329  -22.33452 25.27705  1.000 31.92254  ? 4   ARG A NH2  1 
ATOM   52   H H    . ARG A 1 4   ? -5.87667  -21.85350 30.59662  1.000 38.81096  ? 4   ARG A H    1 
ATOM   53   H HA   . ARG A 1 4   ? -4.73686  -20.61154 28.47574  1.000 35.19132  ? 4   ARG A HA   1 
ATOM   54   H HB2  . ARG A 1 4   ? -3.99658  -23.17945 29.37881  1.000 37.26010  ? 4   ARG A HB2  1 
ATOM   55   H HB3  . ARG A 1 4   ? -3.66025  -22.67229 27.91079  1.000 37.26010  ? 4   ARG A HB3  1 
ATOM   56   H HG2  . ARG A 1 4   ? -2.59276  -21.50739 30.23868  1.000 42.00081  ? 4   ARG A HG2  1 
ATOM   57   H HG3  . ARG A 1 4   ? -1.79915  -22.52433 29.31055  1.000 42.00081  ? 4   ARG A HG3  1 
ATOM   58   H HD2  . ARG A 1 4   ? -2.60400  -19.91712 28.57474  1.000 42.83464  ? 4   ARG A HD2  1 
ATOM   59   H HD3  . ARG A 1 4   ? -1.10410  -20.42413 28.71139  1.000 42.83464  ? 4   ARG A HD3  1 
ATOM   60   H HE   . ARG A 1 4   ? -2.64355  -20.77505 26.57120  1.000 36.06232  ? 4   ARG A HE   1 
ATOM   61   H HH11 . ARG A 1 4   ? 0.04022   -22.07781 28.00616  1.000 48.50392  ? 4   ARG A HH11 1 
ATOM   62   H HH12 . ARG A 1 4   ? 0.46707   -22.87797 26.82448  1.000 48.50392  ? 4   ARG A HH12 1 
ATOM   63   H HH21 . ARG A 1 4   ? -2.05747  -22.06586 24.84631  1.000 38.36115  ? 4   ARG A HH21 1 
ATOM   64   H HH22 . ARG A 1 4   ? -0.80662  -22.87269 24.90278  1.000 38.36115  ? 4   ARG A HH22 1 
ATOM   65   N N    . LYS A 1 5   ? -6.21462  -21.77926 26.84154  1.000 31.37214  ? 5   LYS A N    1 
ATOM   66   C CA   . LYS A 1 5   ? -7.18145  -22.47047 26.00583  1.000 30.83427  ? 5   LYS A CA   1 
ATOM   67   C C    . LYS A 1 5   ? -6.71363  -23.92606 25.84282  1.000 30.15026  ? 5   LYS A C    1 
ATOM   68   O O    . LYS A 1 5   ? -5.62038  -24.18731 25.34196  1.000 32.31383  ? 5   LYS A O    1 
ATOM   69   C CB   . LYS A 1 5   ? -7.31941  -21.77097 24.66887  1.000 34.45495  ? 5   LYS A CB   1 
ATOM   70   C CG   . LYS A 1 5   ? -8.69521  -21.91914 24.10984  1.000 43.43103  ? 5   LYS A CG   1 
ATOM   71   C CD   . LYS A 1 5   ? -8.77459  -21.34038 22.72151  1.000 42.59209  ? 5   LYS A CD   1 
ATOM   72   C CE   . LYS A 1 5   ? -9.18153  -19.88464 22.72795  1.000 40.52761  ? 5   LYS A CE   1 
ATOM   73   N NZ   . LYS A 1 5   ? -9.21908  -19.36681 21.33970  1.000 51.14730  ? 5   LYS A NZ   1 
ATOM   74   H H    . LYS A 1 5   ? -5.73382  -21.19107 26.43847  1.000 37.70067  ? 5   LYS A H    1 
ATOM   75   H HA   . LYS A 1 5   ? -8.06046  -22.46437 26.41595  1.000 37.05522  ? 5   LYS A HA   1 
ATOM   76   H HB2  . LYS A 1 5   ? -7.13631  -20.82517 24.78217  1.000 41.40004  ? 5   LYS A HB2  1 
ATOM   77   H HB3  . LYS A 1 5   ? -6.69091  -22.15745 24.03916  1.000 41.40004  ? 5   LYS A HB3  1 
ATOM   78   H HG2  . LYS A 1 5   ? -8.92678  -22.86001 24.06462  1.000 52.17134  ? 5   LYS A HG2  1 
ATOM   79   H HG3  . LYS A 1 5   ? -9.32712  -21.44878 24.67583  1.000 52.17134  ? 5   LYS A HG3  1 
ATOM   80   H HD2  . LYS A 1 5   ? -7.90430  -21.40801 22.29850  1.000 51.16461  ? 5   LYS A HD2  1 
ATOM   81   H HD3  . LYS A 1 5   ? -9.43240  -21.83479 22.20795  1.000 51.16461  ? 5   LYS A HD3  1 
ATOM   82   H HE2  . LYS A 1 5   ? -10.06446 -19.79318 23.11907  1.000 48.68724  ? 5   LYS A HE2  1 
ATOM   83   H HE3  . LYS A 1 5   ? -8.53805  -19.36700 23.23675  1.000 48.68724  ? 5   LYS A HE3  1 
ATOM   84   H HZ1  . LYS A 1 5   ? -9.80718  -19.82962 20.85799  1.000 61.43086  ? 5   LYS A HZ1  1 
ATOM   85   H HZ2  . LYS A 1 5   ? -9.45776  -18.50941 21.34098  1.000 61.43086  ? 5   LYS A HZ2  1 
ATOM   86   H HZ3  . LYS A 1 5   ? -8.41544  -19.44236 20.96479  1.000 61.43086  ? 5   LYS A HZ3  1 
ATOM   87   N N    . MET A 1 6   ? -7.53633  -24.86126 26.29037  1.000 29.93696  ? 6   MET A N    1 
ATOM   88   C CA   . MET A 1 6   ? -7.13837  -26.25093 26.48891  1.000 29.33427  ? 6   MET A CA   1 
ATOM   89   C C    . MET A 1 6   ? -8.08655  -27.19213 25.76416  1.000 29.88825  ? 6   MET A C    1 
ATOM   90   O O    . MET A 1 6   ? -9.30017  -27.08991 25.95955  1.000 35.05506  ? 6   MET A O    1 
ATOM   91   C CB   . MET A 1 6   ? -7.21040  -26.51718 28.00703  1.000 36.77163  ? 6   MET A CB   1 
ATOM   92   C CG   . MET A 1 6   ? -6.39401  -27.61251 28.47600  1.000 40.98633  ? 6   MET A CG   1 
ATOM   93   S SD   . MET A 1 6   ? -6.46957  -27.60964 30.27486  1.000 41.81487  ? 6   MET A SD   1 
ATOM   94   C CE   . MET A 1 6   ? -5.49546  -26.22071 30.72469  1.000 38.29711  ? 6   MET A CE   1 
ATOM   95   H H    . MET A 1 6   ? -8.35870  -24.71312 26.49375  1.000 35.97845  ? 6   MET A H    1 
ATOM   96   H HA   . MET A 1 6   ? -6.25122  -26.41143 26.13097  1.000 35.25522  ? 6   MET A HA   1 
ATOM   97   H HB2  . MET A 1 6   ? -6.91914  -25.71768 28.47272  1.000 44.18006  ? 6   MET A HB2  1 
ATOM   98   H HB3  . MET A 1 6   ? -8.13002  -26.72006 28.23947  1.000 44.18006  ? 6   MET A HB3  1 
ATOM   99   H HG2  . MET A 1 6   ? -6.73722  -28.45544 28.14047  1.000 49.23770  ? 6   MET A HG2  1 
ATOM   100  H HG3  . MET A 1 6   ? -5.47437  -27.49213 28.19198  1.000 49.23770  ? 6   MET A HG3  1 
ATOM   101  H HE1  . MET A 1 6   ? -4.78639  -26.10773 30.07250  1.000 46.01064  ? 6   MET A HE1  1 
ATOM   102  H HE2  . MET A 1 6   ? -6.05914  -25.43146 30.74055  1.000 46.01064  ? 6   MET A HE2  1 
ATOM   103  H HE3  . MET A 1 6   ? -5.11503  -26.37320 31.60385  1.000 46.01064  ? 6   MET A HE3  1 
ATOM   104  N N    . ALA A 1 7   ? -7.55176  -28.11711 24.96881  1.000 27.49647  ? 7   ALA A N    1 
ATOM   105  C CA   . ALA A 1 7   ? -8.40532  -29.14357 24.37114  1.000 26.20775  ? 7   ALA A CA   1 
ATOM   106  C C    . ALA A 1 7   ? -8.45291  -30.41926 25.20107  1.000 26.38660  ? 7   ALA A C    1 
ATOM   107  O O    . ALA A 1 7   ? -7.58249  -30.69177 26.01465  1.000 29.49693  ? 7   ALA A O    1 
ATOM   108  C CB   . ALA A 1 7   ? -7.89343  -29.49807 22.98282  1.000 31.10646  ? 7   ALA A CB   1 
ATOM   109  H H    . ALA A 1 7   ? -6.71798  -28.17035 24.76491  1.000 33.04986  ? 7   ALA A H    1 
ATOM   110  H HA   . ALA A 1 7   ? -9.30624  -28.78752 24.32137  1.000 31.50340  ? 7   ALA A HA   1 
ATOM   111  H HB1  . ALA A 1 7   ? -6.92452  -29.53861 23.00432  1.000 37.38186  ? 7   ALA A HB1  1 
ATOM   112  H HB2  . ALA A 1 7   ? -8.25489  -30.36006 22.72355  1.000 37.38186  ? 7   ALA A HB2  1 
ATOM   113  H HB3  . ALA A 1 7   ? -8.18215  -28.81628 22.35616  1.000 37.38186  ? 7   ALA A HB3  1 
ATOM   114  N N    . PHE A 1 8   ? -9.47588  -31.23257 24.94233  1.000 28.86840  ? 8   PHE A N    1 
ATOM   115  C CA   . PHE A 1 8   ? -9.52061  -32.55292 25.54501  1.000 29.46717  ? 8   PHE A CA   1 
ATOM   116  C C    . PHE A 1 8   ? -8.41054  -33.42529 24.99122  1.000 31.11469  ? 8   PHE A C    1 
ATOM   117  O O    . PHE A 1 8   ? -8.01780  -33.30089 23.81724  1.000 29.35492  ? 8   PHE A O    1 
ATOM   118  C CB   . PHE A 1 8   ? -10.85726 -33.22062 25.32157  1.000 29.10891  ? 8   PHE A CB   1 
ATOM   119  C CG   . PHE A 1 8   ? -11.98352 -32.57988 26.03940  1.000 28.51102  ? 8   PHE A CG   1 
ATOM   120  C CD1  . PHE A 1 8   ? -12.26380 -32.89833 27.36283  1.000 35.33214  ? 8   PHE A CD1  1 
ATOM   121  C CD2  . PHE A 1 8   ? -12.78961 -31.67103 25.39162  1.000 36.77383  ? 8   PHE A CD2  1 
ATOM   122  C CE1  . PHE A 1 8   ? -13.34948 -32.31453 28.00314  1.000 35.90782  ? 8   PHE A CE1  1 
ATOM   123  C CE2  . PHE A 1 8   ? -13.84215 -31.08273 26.02010  1.000 37.39465  ? 8   PHE A CE2  1 
ATOM   124  C CZ   . PHE A 1 8   ? -14.13814 -31.40540 27.33372  1.000 34.76132  ? 8   PHE A CZ   1 
ATOM   125  H H    . PHE A 1 8   ? -10.14114 -31.04378 24.43107  1.000 34.69618  ? 8   PHE A H    1 
ATOM   126  H HA   . PHE A 1 8   ? -9.39632  -32.46318 26.50282  1.000 35.41470  ? 8   PHE A HA   1 
ATOM   127  H HB2  . PHE A 1 8   ? -11.06115 -33.19703 24.37354  1.000 34.98480  ? 8   PHE A HB2  1 
ATOM   128  H HB3  . PHE A 1 8   ? -10.79948 -34.13989 25.62572  1.000 34.98480  ? 8   PHE A HB3  1 
ATOM   129  H HD1  . PHE A 1 8   ? -11.72433 -33.50246 27.81988  1.000 42.45267  ? 8   PHE A HD1  1 
ATOM   130  H HD2  . PHE A 1 8   ? -12.61039 -31.45480 24.50504  1.000 44.18270  ? 8   PHE A HD2  1 
ATOM   131  H HE1  . PHE A 1 8   ? -13.54397 -32.53782 28.88474  1.000 43.14349  ? 8   PHE A HE1  1 
ATOM   132  H HE2  . PHE A 1 8   ? -14.36486 -30.46169 25.56625  1.000 44.92769  ? 8   PHE A HE2  1 
ATOM   133  H HZ   . PHE A 1 8   ? -14.86414 -31.01111 27.76077  1.000 41.76769  ? 8   PHE A HZ   1 
ATOM   134  N N    . PRO A 1 9   ? -7.90992  -34.34647 25.80749  1.000 33.62078  ? 9   PRO A N    1 
ATOM   135  C CA   . PRO A 1 9   ? -7.02773  -35.39921 25.29069  1.000 33.22290  ? 9   PRO A CA   1 
ATOM   136  C C    . PRO A 1 9   ? -7.74101  -36.13625 24.15972  1.000 27.40911  ? 9   PRO A C    1 
ATOM   137  O O    . PRO A 1 9   ? -8.93065  -36.44572 24.25420  1.000 35.11672  ? 9   PRO A O    1 
ATOM   138  C CB   . PRO A 1 9   ? -6.77734  -36.29790 26.51499  1.000 36.61288  ? 9   PRO A CB   1 
ATOM   139  C CG   . PRO A 1 9   ? -7.20954  -35.48181 27.72419  1.000 41.72387  ? 9   PRO A CG   1 
ATOM   140  C CD   . PRO A 1 9   ? -8.34929  -34.61161 27.19522  1.000 34.64998  ? 9   PRO A CD   1 
ATOM   141  H HA   . PRO A 1 9   ? -6.17494  -35.04989 24.98798  1.000 39.92158  ? 9   PRO A HA   1 
ATOM   142  H HB2  . PRO A 1 9   ? -7.30603  -37.10764 26.43954  1.000 43.98955  ? 9   PRO A HB2  1 
ATOM   143  H HB3  . PRO A 1 9   ? -5.83488  -36.52088 26.56937  1.000 43.98955  ? 9   PRO A HB3  1 
ATOM   144  H HG2  . PRO A 1 9   ? -7.51705  -36.06953 28.43195  1.000 50.12275  ? 9   PRO A HG2  1 
ATOM   145  H HG3  . PRO A 1 9   ? -6.47188  -34.93782 28.04173  1.000 50.12275  ? 9   PRO A HG3  1 
ATOM   146  H HD2  . PRO A 1 9   ? -9.19257  -35.09070 27.21064  1.000 41.63407  ? 9   PRO A HD2  1 
ATOM   147  H HD3  . PRO A 1 9   ? -8.42621  -33.78819 27.70213  1.000 41.63407  ? 9   PRO A HD3  1 
ATOM   148  N N    . SER A 1 10  ? -7.02363  -36.36206 23.08737  1.000 31.92620  ? 10  SER A N    1 
ATOM   149  C CA   . SER A 1 10  ? -7.65994  -36.75571 21.84054  1.000 35.60989  ? 10  SER A CA   1 
ATOM   150  C C    . SER A 1 10  ? -7.55079  -38.23502 21.53939  1.000 37.09199  ? 10  SER A C    1 
ATOM   151  O O    . SER A 1 10  ? -8.07475  -38.67108 20.51523  1.000 31.82595  ? 10  SER A O    1 
ATOM   152  C CB   . SER A 1 10  ? -7.07802  -35.95073 20.70245  1.000 31.15310  ? 10  SER A CB   1 
ATOM   153  O OG   . SER A 1 10  ? -5.67518  -36.11435 20.57804  1.000 32.40139  ? 10  SER A OG   1 
ATOM   154  H H    . SER A 1 10  ? -6.16702  -36.29598 23.04926  1.000 38.36554  ? 10  SER A H    1 
ATOM   155  H HA   . SER A 1 10  ? -8.60715  -36.55601 21.90233  1.000 42.78597  ? 10  SER A HA   1 
ATOM   156  H HB2  . SER A 1 10  ? -7.49647  -36.23819 19.87592  1.000 37.43782  ? 10  SER A HB2  1 
ATOM   157  H HB3  . SER A 1 10  ? -7.26617  -35.01240 20.86070  1.000 37.43782  ? 10  SER A HB3  1 
ATOM   158  H HG   . SER A 1 10  ? -5.30435  -35.98967 21.32137  1.000 38.93577  ? 10  SER A HG   1 
ATOM   159  N N    . GLY A 1 11  ? -6.92771  -39.02319 22.42171  1.000 34.41655  ? 11  GLY A N    1 
ATOM   160  C CA   . GLY A 1 11  ? -6.64161  -40.41455 22.07481  1.000 33.64824  ? 11  GLY A CA   1 
ATOM   161  C C    . GLY A 1 11  ? -7.86843  -41.21942 21.68035  1.000 34.78056  ? 11  GLY A C    1 
ATOM   162  O O    . GLY A 1 11  ? -7.82401  -42.00337 20.72223  1.000 35.88763  ? 11  GLY A O    1 
ATOM   163  H H    . GLY A 1 11  ? -6.66783  -38.78282 23.20548  1.000 41.35396  ? 11  GLY A H    1 
ATOM   164  H HA2  . GLY A 1 11  ? -6.02105  -40.43157 21.32948  1.000 40.43198  ? 11  GLY A HA2  1 
ATOM   165  H HA3  . GLY A 1 11  ? -6.23096  -40.85077 22.83768  1.000 40.43198  ? 11  GLY A HA3  1 
ATOM   166  N N    . LYS A 1 12  ? -8.96235  -41.05949 22.40937  1.000 31.87933  ? 12  LYS A N    1 
ATOM   167  C CA   . LYS A 1 12  ? -10.16643 -41.82362 22.11360  1.000 31.75645  ? 12  LYS A CA   1 
ATOM   168  C C    . LYS A 1 12  ? -10.67020 -41.54974 20.70339  1.000 38.01099  ? 12  LYS A C    1 
ATOM   169  O O    . LYS A 1 12  ? -11.25235 -42.43809 20.07669  1.000 37.26512  ? 12  LYS A O    1 
ATOM   170  C CB   . LYS A 1 12  ? -11.26516 -41.50607 23.11978  1.000 38.94705  ? 12  LYS A CB   1 
ATOM   171  C CG   . LYS A 1 12  ? -10.98565 -42.02467 24.56480  1.000 39.10866  ? 12  LYS A CG   1 
ATOM   172  C CD   . LYS A 1 12  ? -12.26399 -41.95831 25.39805  1.000 59.01269  ? 12  LYS A CD   1 
ATOM   173  C CE   . LYS A 1 12  ? -12.04852 -42.24405 26.89777  1.000 60.39072  ? 12  LYS A CE   1 
ATOM   174  N NZ   . LYS A 1 12  ? -12.08455 -40.98440 27.71875  1.000 63.63760  ? 12  LYS A NZ   1 
ATOM   175  H H    . LYS A 1 12  ? -9.03558  -40.52038 23.07541  1.000 38.30930  ? 12  LYS A H    1 
ATOM   176  H HA   . LYS A 1 12  ? -9.95163  -42.76648 22.18961  1.000 38.16184  ? 12  LYS A HA   1 
ATOM   177  H HB2  . LYS A 1 12  ? -11.37058 -40.54307 23.16896  1.000 46.79057  ? 12  LYS A HB2  1 
ATOM   178  H HB3  . LYS A 1 12  ? -12.09052 -41.91507 22.81582  1.000 46.79057  ? 12  LYS A HB3  1 
ATOM   179  H HG2  . LYS A 1 12  ? -10.68450 -42.94605 24.52931  1.000 46.98449  ? 12  LYS A HG2  1 
ATOM   180  H HG3  . LYS A 1 12  ? -10.31003 -41.47081 24.98632  1.000 46.98449  ? 12  LYS A HG3  1 
ATOM   181  H HD2  . LYS A 1 12  ? -12.64202 -41.06850 25.31911  1.000 70.86932  ? 12  LYS A HD2  1 
ATOM   182  H HD3  . LYS A 1 12  ? -12.89127 -42.61645 25.05999  1.000 70.86932  ? 12  LYS A HD3  1 
ATOM   183  H HE2  . LYS A 1 12  ? -12.75064 -42.83332 27.21508  1.000 72.52296  ? 12  LYS A HE2  1 
ATOM   184  H HE3  . LYS A 1 12  ? -11.18247 -42.66280 27.02227  1.000 72.52296  ? 12  LYS A HE3  1 
ATOM   185  H HZ1  . LYS A 1 12  ? -11.86081 -41.16370 28.56130  1.000 76.41923  ? 12  LYS A HZ1  1 
ATOM   186  H HZ2  . LYS A 1 12  ? -11.51148 -40.38909 27.38815  1.000 76.41923  ? 12  LYS A HZ2  1 
ATOM   187  H HZ3  . LYS A 1 12  ? -12.90324 -40.63559 27.70528  1.000 76.41923  ? 12  LYS A HZ3  1 
ATOM   188  N N    . VAL A 1 13  ? -10.48537 -40.33581 20.20652  1.000 31.16558  ? 13  VAL A N    1 
ATOM   189  C CA   . VAL A 1 13  ? -10.94142 -39.96432 18.87262  1.000 32.85069  ? 13  VAL A CA   1 
ATOM   190  C C    . VAL A 1 13  ? -9.92514  -40.33768 17.81269  1.000 31.47445  ? 13  VAL A C    1 
ATOM   191  O O    . VAL A 1 13  ? -10.29398 -40.71038 16.70174  1.000 33.52599  ? 13  VAL A O    1 
ATOM   192  C CB   . VAL A 1 13  ? -11.26825 -38.45908 18.82942  1.000 25.44021  ? 13  VAL A CB   1 
ATOM   193  C CG1  . VAL A 1 13  ? -11.67316 -38.04911 17.38883  1.000 29.39659  ? 13  VAL A CG1  1 
ATOM   194  C CG2  . VAL A 1 13  ? -12.34584 -38.09775 19.75682  1.000 29.98810  ? 13  VAL A CG2  1 
ATOM   195  H H    . VAL A 1 13  ? -10.09226 -39.69692 20.62709  1.000 37.45279  ? 13  VAL A H    1 
ATOM   196  H HA   . VAL A 1 13  ? -11.75654 -40.45446 18.68224  1.000 39.47492  ? 13  VAL A HA   1 
ATOM   197  H HB   . VAL A 1 13  ? -10.47179 -37.97738 19.10242  1.000 30.58235  ? 13  VAL A HB   1 
ATOM   198  H HG11 . VAL A 1 13  ? -12.27029 -37.28600 17.43370  1.000 35.33000  ? 13  VAL A HG11 1 
ATOM   199  H HG12 . VAL A 1 13  ? -10.87435 -37.81521 16.89074  1.000 35.33000  ? 13  VAL A HG12 1 
ATOM   200  H HG13 . VAL A 1 13  ? -12.12210 -38.79577 16.96239  1.000 35.33000  ? 13  VAL A HG13 1 
ATOM   201  H HG21 . VAL A 1 13  ? -12.43870 -37.13233 19.77230  1.000 36.03982  ? 13  VAL A HG21 1 
ATOM   202  H HG22 . VAL A 1 13  ? -13.17267 -38.50478 19.45419  1.000 36.03982  ? 13  VAL A HG22 1 
ATOM   203  H HG23 . VAL A 1 13  ? -12.12212 -38.42279 20.64294  1.000 36.03982  ? 13  VAL A HG23 1 
ATOM   204  N N    . GLU A 1 14  ? -8.62544  -40.21582 18.12523  1.000 29.78740  ? 14  GLU A N    1 
ATOM   205  C CA   . GLU A 1 14  ? -7.59913  -40.64620 17.17986  1.000 29.59379  ? 14  GLU A CA   1 
ATOM   206  C C    . GLU A 1 14  ? -7.89472  -42.04348 16.65363  1.000 36.26342  ? 14  GLU A C    1 
ATOM   207  O O    . GLU A 1 14  ? -7.67995  -42.33158 15.46289  1.000 32.46220  ? 14  GLU A O    1 
ATOM   208  C CB   . GLU A 1 14  ? -6.21580  -40.60690 17.83288  1.000 31.09242  ? 14  GLU A CB   1 
ATOM   209  C CG   . GLU A 1 14  ? -5.78949  -39.18509 18.23860  1.000 31.21644  ? 14  GLU A CG   1 
ATOM   210  C CD   . GLU A 1 14  ? -4.54943  -39.14021 19.12428  1.000 31.52245  ? 14  GLU A CD   1 
ATOM   211  O OE1  . GLU A 1 14  ? -3.58111  -39.85632 18.84113  1.000 37.05171  ? 14  GLU A OE1  1 
ATOM   212  O OE2  . GLU A 1 14  ? -4.58431  -38.40877 20.11537  1.000 35.95578  ? 14  GLU A OE2  1 
ATOM   213  H H    . GLU A 1 14  ? -8.32326  -39.89365 18.86312  1.000 35.79898  ? 14  GLU A H    1 
ATOM   214  H HA   . GLU A 1 14  ? -7.58955  -40.02912 16.43151  1.000 35.56666  ? 14  GLU A HA   1 
ATOM   215  H HB2  . GLU A 1 14  ? -6.22829  -41.15637 18.63214  1.000 37.36500  ? 14  GLU A HB2  1 
ATOM   216  H HB3  . GLU A 1 14  ? -5.56049  -40.94937 17.20505  1.000 37.36500  ? 14  GLU A HB3  1 
ATOM   217  H HG2  . GLU A 1 14  ? -5.59681  -38.67648 17.43543  1.000 37.51382  ? 14  GLU A HG2  1 
ATOM   218  H HG3  . GLU A 1 14  ? -6.51662  -38.76953 18.72798  1.000 37.51382  ? 14  GLU A HG3  1 
ATOM   219  N N    . GLY A 1 15  ? -8.39927  -42.91714 17.51177  1.000 33.96009  ? 15  GLY A N    1 
ATOM   220  C CA   . GLY A 1 15  ? -8.60387  -44.30953 17.14114  1.000 39.37349  ? 15  GLY A CA   1 
ATOM   221  C C    . GLY A 1 15  ? -9.79140  -44.55633 16.25582  1.000 38.66842  ? 15  GLY A C    1 
ATOM   222  O O    . GLY A 1 15  ? -10.04961 -45.68096 15.83777  1.000 36.02119  ? 15  GLY A O    1 
ATOM   223  H H    . GLY A 1 15  ? -8.63207  -42.72794 18.31775  1.000 40.80621  ? 15  GLY A H    1 
ATOM   224  H HA2  . GLY A 1 15  ? -7.81491  -44.62603 16.67394  1.000 47.30229  ? 15  GLY A HA2  1 
ATOM   225  H HA3  . GLY A 1 15  ? -8.72307  -44.83214 17.94957  1.000 47.30229  ? 15  GLY A HA3  1 
ATOM   226  N N    . CYS A 1 16  ? -10.52012 -43.48858 15.94102  1.000 32.22158  ? 16  CYS A N    1 
ATOM   227  C CA   . CYS A 1 16  ? -11.69577 -43.56904 15.10398  1.000 32.28797  ? 16  CYS A CA   1 
ATOM   228  C C    . CYS A 1 16  ? -11.49424 -42.93548 13.73706  1.000 31.61699  ? 16  CYS A C    1 
ATOM   229  O O    . CYS A 1 16  ? -12.42342 -42.96734 12.94635  1.000 32.21655  ? 16  CYS A O    1 
ATOM   230  C CB   . CYS A 1 16  ? -12.88722 -42.90741 15.79822  1.000 28.56403  ? 16  CYS A CB   1 
ATOM   231  S SG   . CYS A 1 16  ? -13.33141 -43.56561 17.42580  1.000 35.98329  ? 16  CYS A SG   1 
ATOM   232  H H    . CYS A 1 16  ? -10.34342 -42.69113 16.21020  1.000 38.71999  ? 16  CYS A H    1 
ATOM   233  H HA   . CYS A 1 16  ? -11.91043 -44.50550 14.97032  1.000 38.79966  ? 16  CYS A HA   1 
ATOM   234  H HB2  . CYS A 1 16  ? -12.68359 -41.96643 15.91648  1.000 34.33094  ? 16  CYS A HB2  1 
ATOM   235  H HB3  . CYS A 1 16  ? -13.66452 -43.00940 15.22699  1.000 34.33094  ? 16  CYS A HB3  1 
ATOM   236  H HG   . CYS A 1 16  ? -12.33614 -43.67787 18.08673  1.000 43.23405  ? 16  CYS A HG   1 
ATOM   237  N N    . MET A 1 17  ? -10.34978 -42.30348 13.46700  1.000 27.60263  ? 17  MET A N    1 
ATOM   238  C CA   . MET A 1 17  ? -10.15722 -41.56109 12.23351  1.000 31.62761  ? 17  MET A CA   1 
ATOM   239  C C    . MET A 1 17  ? -9.71790  -42.54525 11.15321  1.000 30.65970  ? 17  MET A C    1 
ATOM   240  O O    . MET A 1 17  ? -8.87857  -43.41681 11.40912  1.000 34.95327  ? 17  MET A O    1 
ATOM   241  C CB   . MET A 1 17  ? -9.14122  -40.43278 12.40131  1.000 32.13539  ? 17  MET A CB   1 
ATOM   242  C CG   . MET A 1 17  ? -9.62134  -39.32458 13.38515  1.000 26.04391  ? 17  MET A CG   1 
ATOM   243  S SD   . MET A 1 17  ? -11.37344 -38.87601 13.37721  1.000 30.58450  ? 17  MET A SD   1 
ATOM   244  C CE   . MET A 1 17  ? -11.55413 -38.24046 11.72695  1.000 33.40559  ? 17  MET A CE   1 
ATOM   245  H H    . MET A 1 17  ? -9.66785  -42.29353 13.99089  1.000 33.17726  ? 17  MET A H    1 
ATOM   246  H HA   . MET A 1 17  ? -10.98801 -41.13235 11.97492  1.000 38.00723  ? 17  MET A HA   1 
ATOM   247  H HB2  . MET A 1 17  ? -8.31401  -40.80274 12.74736  1.000 38.61657  ? 17  MET A HB2  1 
ATOM   248  H HB3  . MET A 1 17  ? -8.98420  -40.01941 11.53796  1.000 38.61657  ? 17  MET A HB3  1 
ATOM   249  H HG2  . MET A 1 17  ? -9.41570  -39.62042 14.28576  1.000 31.30679  ? 17  MET A HG2  1 
ATOM   250  H HG3  . MET A 1 17  ? -9.12767  -38.51492 13.18108  1.000 31.30679  ? 17  MET A HG3  1 
ATOM   251  H HE1  . MET A 1 17  ? -12.44932 -37.88169 11.62296  1.000 40.14081  ? 17  MET A HE1  1 
ATOM   252  H HE2  . MET A 1 17  ? -10.89844 -37.53992 11.58478  1.000 40.14081  ? 17  MET A HE2  1 
ATOM   253  H HE3  . MET A 1 17  ? -11.41092 -38.96104 11.09359  1.000 40.14081  ? 17  MET A HE3  1 
ATOM   254  N N    . VAL A 1 18  ? -10.36157 -42.46653 9.99196   1.000 31.81905  ? 18  VAL A N    1 
ATOM   255  C CA   . VAL A 1 18  ? -10.02400 -43.26641 8.82712   1.000 30.57842  ? 18  VAL A CA   1 
ATOM   256  C C    . VAL A 1 18  ? -9.99090  -42.34829 7.61641   1.000 32.60700  ? 18  VAL A C    1 
ATOM   257  O O    . VAL A 1 18  ? -10.42647 -41.19163 7.66713   1.000 28.55166  ? 18  VAL A O    1 
ATOM   258  C CB   . VAL A 1 18  ? -11.00510 -44.44210 8.58608   1.000 28.63429  ? 18  VAL A CB   1 
ATOM   259  C CG1  . VAL A 1 18  ? -11.01354 -45.38522 9.77510   1.000 35.54851  ? 18  VAL A CG1  1 
ATOM   260  C CG2  . VAL A 1 18  ? -12.40982 -43.97149 8.25826   1.000 33.50387  ? 18  VAL A CG2  1 
ATOM   261  H H    . VAL A 1 18  ? -11.02303 -41.93485 9.85271   1.000 38.23696  ? 18  VAL A H    1 
ATOM   262  H HA   . VAL A 1 18  ? -9.14135  -43.64668 8.95841   1.000 36.74820  ? 18  VAL A HA   1 
ATOM   263  H HB   . VAL A 1 18  ? -10.68911 -44.92806 7.80833   1.000 34.41525  ? 18  VAL A HB   1 
ATOM   264  H HG11 . VAL A 1 18  ? -10.52195 -44.97744 10.50513  1.000 42.71231  ? 18  VAL A HG11 1 
ATOM   265  H HG12 . VAL A 1 18  ? -11.93154 -45.54642 10.04381  1.000 42.71231  ? 18  VAL A HG12 1 
ATOM   266  H HG13 . VAL A 1 18  ? -10.59242 -46.22055 9.51861   1.000 42.71231  ? 18  VAL A HG13 1 
ATOM   267  H HG21 . VAL A 1 18  ? -12.88512 -44.68649 7.80685   1.000 40.25875  ? 18  VAL A HG21 1 
ATOM   268  H HG22 . VAL A 1 18  ? -12.86576 -43.74007 9.08255   1.000 40.25875  ? 18  VAL A HG22 1 
ATOM   269  H HG23 . VAL A 1 18  ? -12.35569 -43.19407 7.68069   1.000 40.25875  ? 18  VAL A HG23 1 
ATOM   270  N N    . GLN A 1 19  ? -9.45131  -42.87353 6.51528   1.000 32.03567  ? 19  GLN A N    1 
ATOM   271  C CA   . GLN A 1 19  ? -9.35574  -42.16481 5.25471   1.000 32.20912  ? 19  GLN A CA   1 
ATOM   272  C C    . GLN A 1 19  ? -10.45235 -42.67795 4.33107   1.000 30.34467  ? 19  GLN A C    1 
ATOM   273  O O    . GLN A 1 19  ? -10.66797 -43.88789 4.23194   1.000 33.24793  ? 19  GLN A O    1 
ATOM   274  C CB   . GLN A 1 19  ? -7.97471  -42.39941 4.62383   1.000 31.62476  ? 19  GLN A CB   1 
ATOM   275  C CG   . GLN A 1 19  ? -7.78752  -41.75471 3.29034   1.000 42.38567  ? 19  GLN A CG   1 
ATOM   276  C CD   . GLN A 1 19  ? -6.51472  -42.21842 2.63027   1.000 42.29452  ? 19  GLN A CD   1 
ATOM   277  O OE1  . GLN A 1 19  ? -6.41904  -43.36356 2.19333   1.000 51.30903  ? 19  GLN A OE1  1 
ATOM   278  N NE2  . GLN A 1 19  ? -5.51917  -41.35521 2.59734   1.000 44.18396  ? 19  GLN A NE2  1 
ATOM   279  H H    . GLN A 1 19  ? -9.12400  -43.66802 6.47979   1.000 38.49691  ? 19  GLN A H    1 
ATOM   280  H HA   . GLN A 1 19  ? -9.47106  -41.20982 5.37955   1.000 38.70504  ? 19  GLN A HA   1 
ATOM   281  H HB2  . GLN A 1 19  ? -7.29783  -42.04231 5.21984   1.000 38.00381  ? 19  GLN A HB2  1 
ATOM   282  H HB3  . GLN A 1 19  ? -7.84540  -43.35385 4.50889   1.000 38.00381  ? 19  GLN A HB3  1 
ATOM   283  H HG2  . GLN A 1 19  ? -8.53271  -41.98597 2.71404   1.000 50.91690  ? 19  GLN A HG2  1 
ATOM   284  H HG3  . GLN A 1 19  ? -7.74092  -40.79232 3.40228   1.000 50.91690  ? 19  GLN A HG3  1 
ATOM   285  H HE21 . GLN A 1 19  ? -5.61639  -40.57334 2.94206   1.000 53.07485  ? 19  GLN A HE21 1 
ATOM   286  H HE22 . GLN A 1 19  ? -4.77239  -41.57386 2.23113   1.000 53.07485  ? 19  GLN A HE22 1 
ATOM   287  N N    . VAL A 1 20  ? -11.14751 -41.76866 3.65904   1.000 29.28243  ? 20  VAL A N    1 
ATOM   288  C CA   . VAL A 1 20  ? -12.19817 -42.15197 2.71068   1.000 32.22812  ? 20  VAL A CA   1 
ATOM   289  C C    . VAL A 1 20  ? -11.89856 -41.52348 1.36437   1.000 32.67766  ? 20  VAL A C    1 
ATOM   290  O O    . VAL A 1 20  ? -11.77955 -40.29292 1.24925   1.000 33.29285  ? 20  VAL A O    1 
ATOM   291  C CB   . VAL A 1 20  ? -13.59601 -41.74132 3.19998   1.000 33.77898  ? 20  VAL A CB   1 
ATOM   292  C CG1  . VAL A 1 20  ? -14.66736 -42.10264 2.14327   1.000 39.19507  ? 20  VAL A CG1  1 
ATOM   293  C CG2  . VAL A 1 20  ? -13.89842 -42.42406 4.50754   1.000 32.11609  ? 20  VAL A CG2  1 
ATOM   294  H H    . VAL A 1 20  ? -11.03162 -40.91970 3.73276   1.000 35.19302  ? 20  VAL A H    1 
ATOM   295  H HA   . VAL A 1 20  ? -12.17863 -43.11520 2.59796   1.000 38.72785  ? 20  VAL A HA   1 
ATOM   296  H HB   . VAL A 1 20  ? -13.61874 -40.78111 3.33558   1.000 40.58887  ? 20  VAL A HB   1 
ATOM   297  H HG11 . VAL A 1 20  ? -14.46862 -41.63239 1.31848   1.000 47.08819  ? 20  VAL A HG11 1 
ATOM   298  H HG12 . VAL A 1 20  ? -14.64981 -43.06037 1.99046   1.000 47.08819  ? 20  VAL A HG12 1 
ATOM   299  H HG13 . VAL A 1 20  ? -15.53951 -41.83636 2.47395   1.000 47.08819  ? 20  VAL A HG13 1 
ATOM   300  H HG21 . VAL A 1 20  ? -14.84486 -42.33330 4.69970   1.000 38.59341  ? 20  VAL A HG21 1 
ATOM   301  H HG22 . VAL A 1 20  ? -13.66405 -43.36255 4.43538   1.000 38.59341  ? 20  VAL A HG22 1 
ATOM   302  H HG23 . VAL A 1 20  ? -13.37663 -42.00589 5.21023   1.000 38.59341  ? 20  VAL A HG23 1 
ATOM   303  N N    . THR A 1 21  ? -11.78882 -42.35683 0.32901   1.000 30.74542  ? 21  THR A N    1 
ATOM   304  C CA   . THR A 1 21  ? -11.52006 -41.91854 -1.01959  1.000 33.78932  ? 21  THR A CA   1 
ATOM   305  C C    . THR A 1 21  ? -12.66452 -42.36797 -1.92581  1.000 31.94901  ? 21  THR A C    1 
ATOM   306  O O    . THR A 1 21  ? -13.11641 -43.50365 -1.86024  1.000 36.31624  ? 21  THR A O    1 
ATOM   307  C CB   . THR A 1 21  ? -10.18878 -42.49013 -1.55265  1.000 36.76412  ? 21  THR A CB   1 
ATOM   308  O OG1  . THR A 1 21  ? -9.12656  -42.06696 -0.69898  1.000 35.16648  ? 21  THR A OG1  1 
ATOM   309  C CG2  . THR A 1 21  ? -9.93535  -41.99627 -2.97607  1.000 34.75400  ? 21  THR A CG2  1 
ATOM   310  H H    . THR A 1 21  ? -11.87085 -43.21028 0.39609   1.000 36.94860  ? 21  THR A H    1 
ATOM   311  H HA   . THR A 1 21  ? -11.45796 -40.95070 -1.03726  1.000 40.60129  ? 21  THR A HA   1 
ATOM   312  H HB   . THR A 1 21  ? -10.22286 -43.45937 -1.57039  1.000 44.17105  ? 21  THR A HB   1 
ATOM   313  H HG1  . THR A 1 21  ? -9.04633  -41.23148 -0.73275  1.000 42.25388  ? 21  THR A HG1  1 
ATOM   314  H HG21 . THR A 1 21  ? -10.51638 -41.24548 -3.17512  1.000 41.75890  ? 21  THR A HG21 1 
ATOM   315  H HG22 . THR A 1 21  ? -9.01224  -41.71342 -3.06967  1.000 41.75890  ? 21  THR A HG22 1 
ATOM   316  H HG23 . THR A 1 21  ? -10.11234 -42.70820 -3.61068  1.000 41.75890  ? 21  THR A HG23 1 
ATOM   317  N N    . CYS A 1 22  ? -13.11119 -41.47392 -2.78337  1.000 32.74623  ? 22  CYS A N    1 
ATOM   318  C CA   . CYS A 1 22  ? -14.08299 -41.79230 -3.82087  1.000 39.51182  ? 22  CYS A CA   1 
ATOM   319  C C    . CYS A 1 22  ? -13.59271 -41.04439 -5.04620  1.000 39.31463  ? 22  CYS A C    1 
ATOM   320  O O    . CYS A 1 22  ? -13.46280 -39.81374 -5.01239  1.000 40.58641  ? 22  CYS A O    1 
ATOM   321  C CB   . CYS A 1 22  ? -15.50334 -41.38315 -3.41611  1.000 40.24622  ? 22  CYS A CB   1 
ATOM   322  S SG   . CYS A 1 22  ? -16.83084 -41.93514 -4.52995  1.000 43.63720  ? 22  CYS A SG   1 
ATOM   323  H H    . CYS A 1 22  ? -12.86247 -40.65069 -2.78924  1.000 39.34957  ? 22  CYS A H    1 
ATOM   324  H HA   . CYS A 1 22  ? -14.12921 -42.74362 -4.00462  1.000 47.46828  ? 22  CYS A HA   1 
ATOM   325  H HB2  . CYS A 1 22  ? -15.68913 -41.75570 -2.53999  1.000 48.34956  ? 22  CYS A HB2  1 
ATOM   326  H HB3  . CYS A 1 22  ? -15.54213 -40.41461 -3.37980  1.000 48.34956  ? 22  CYS A HB3  1 
ATOM   327  H HG   . CYS A 1 22  ? -16.86122 -43.13474 -4.53715  1.000 52.41875  ? 22  CYS A HG   1 
ATOM   328  N N    . GLY A 1 23  ? -13.23475 -41.78384 -6.09197  1.000 44.76261  ? 23  GLY A N    1 
ATOM   329  C CA   . GLY A 1 23  ? -12.63634 -41.13494 -7.25260  1.000 41.67144  ? 23  GLY A CA   1 
ATOM   330  C C    . GLY A 1 23  ? -11.30385 -40.50886 -6.88717  1.000 35.32302  ? 23  GLY A C    1 
ATOM   331  O O    . GLY A 1 23  ? -10.42137 -41.14824 -6.30666  1.000 42.23119  ? 23  GLY A O    1 
ATOM   332  H H    . GLY A 1 23  ? -13.32443 -42.63693 -6.15361  1.000 53.76923  ? 23  GLY A H    1 
ATOM   333  H HA2  . GLY A 1 23  ? -12.49287 -41.78745 -7.95585  1.000 50.05982  ? 23  GLY A HA2  1 
ATOM   334  H HA3  . GLY A 1 23  ? -13.22822 -40.44062 -7.58199  1.000 50.05982  ? 23  GLY A HA3  1 
ATOM   335  N N    . THR A 1 24  ? -11.13995 -39.24058 -7.24386  1.000 44.50739  ? 24  THR A N    1 
ATOM   336  C CA   . THR A 1 24  ? -9.93256  -38.50181 -6.92275  1.000 48.30213  ? 24  THR A CA   1 
ATOM   337  C C    . THR A 1 24  ? -10.11240 -37.61867 -5.69176  1.000 54.54084  ? 24  THR A C    1 
ATOM   338  O O    . THR A 1 24  ? -9.26559  -36.75746 -5.41842  1.000 49.15546  ? 24  THR A O    1 
ATOM   339  C CB   . THR A 1 24  ? -9.49076  -37.67284 -8.13675  1.000 53.62882  ? 24  THR A CB   1 
ATOM   340  O OG1  . THR A 1 24  ? -8.36528  -36.85732 -7.78691  1.000 62.19310  ? 24  THR A OG1  1 
ATOM   341  C CG2  . THR A 1 24  ? -10.62486 -36.79380 -8.66893  1.000 49.19921  ? 24  THR A CG2  1 
ATOM   342  H H    . THR A 1 24  ? -11.72393 -38.78274 -7.67855  1.000 53.46297  ? 24  THR A H    1 
ATOM   343  H HA   . THR A 1 24  ? -9.21551  -39.12516 -6.72736  1.000 58.01665  ? 24  THR A HA   1 
ATOM   344  H HB   . THR A 1 24  ? -9.23887  -38.27961 -8.85039  1.000 64.40868  ? 24  THR A HB   1 
ATOM   345  H HG1  . THR A 1 24  ? -8.09127  -36.44060 -8.46283  1.000 74.68582  ? 24  THR A HG1  1 
ATOM   346  H HG21 . THR A 1 24  ? -10.26819 -36.11727 -9.26559  1.000 59.09315  ? 24  THR A HG21 1 
ATOM   347  H HG22 . THR A 1 24  ? -11.26503 -37.33655 -9.15524  1.000 59.09315  ? 24  THR A HG22 1 
ATOM   348  H HG23 . THR A 1 24  ? -11.07891 -36.35589 -7.93206  1.000 59.09315  ? 24  THR A HG23 1 
ATOM   349  N N    . THR A 1 25  ? -11.17612 -37.83163 -4.92562  1.000 44.75132  ? 25  THR A N    1 
ATOM   350  C CA   . THR A 1 25  ? -11.45499 -37.03278 -3.72975  1.000 43.18415  ? 25  THR A CA   1 
ATOM   351  C C    . THR A 1 25  ? -11.14138 -37.87087 -2.50121  1.000 40.94438  ? 25  THR A C    1 
ATOM   352  O O    . THR A 1 25  ? -11.69724 -38.96697 -2.34021  1.000 40.04364  ? 25  THR A O    1 
ATOM   353  C CB   . THR A 1 25  ? -12.91126 -36.57834 -3.70431  1.000 39.05220  ? 25  THR A CB   1 
ATOM   354  O OG1  . THR A 1 25  ? -13.23444 -35.96303 -4.95782  1.000 45.95605  ? 25  THR A OG1  1 
ATOM   355  C CG2  . THR A 1 25  ? -13.15373 -35.59877 -2.58421  1.000 37.84642  ? 25  THR A CG2  1 
ATOM   356  H H    . THR A 1 25  ? -11.76212 -38.44236 -5.07798  1.000 53.75568  ? 25  THR A H    1 
ATOM   357  H HA   . THR A 1 25  ? -10.88681 -36.24661 -3.72507  1.000 51.87508  ? 25  THR A HA   1 
ATOM   358  H HB   . THR A 1 25  ? -13.48678 -37.34505 -3.55655  1.000 46.91674  ? 25  THR A HB   1 
ATOM   359  H HG1  . THR A 1 25  ? -12.62282 -35.43359 -5.18412  1.000 55.20137  ? 25  THR A HG1  1 
ATOM   360  H HG21 . THR A 1 25  ? -12.95495 -36.01481 -1.73080  1.000 45.46980  ? 25  THR A HG21 1 
ATOM   361  H HG22 . THR A 1 25  ? -12.58528 -34.82066 -2.69510  1.000 45.46980  ? 25  THR A HG22 1 
ATOM   362  H HG23 . THR A 1 25  ? -14.08104 -35.31419 -2.58728  1.000 45.46980  ? 25  THR A HG23 1 
ATOM   363  N N    . THR A 1 26  ? -10.28471 -37.35009 -1.62600  1.000 41.26346  ? 26  THR A N    1 
ATOM   364  C CA   . THR A 1 26  ? -9.95810  -37.98977 -0.35547  1.000 37.00877  ? 26  THR A CA   1 
ATOM   365  C C    . THR A 1 26  ? -10.26830 -37.05070 0.80933   1.000 35.11187  ? 26  THR A C    1 
ATOM   366  O O    . THR A 1 26  ? -9.93958  -35.85550 0.76923   1.000 35.92624  ? 26  THR A O    1 
ATOM   367  C CB   . THR A 1 26  ? -8.48723  -38.42521 -0.33680  1.000 38.79943  ? 26  THR A CB   1 
ATOM   368  O OG1  . THR A 1 26  ? -8.29866  -39.52868 -1.24437  1.000 48.13495  ? 26  THR A OG1  1 
ATOM   369  C CG2  . THR A 1 26  ? -8.06550  -38.87081 1.03070   1.000 35.97548  ? 26  THR A CG2  1 
ATOM   370  H H    . THR A 1 26  ? -9.86952  -36.60723 -1.74999  1.000 49.57026  ? 26  THR A H    1 
ATOM   371  H HA   . THR A 1 26  ? -10.51461 -38.77527 -0.23641  1.000 44.46463  ? 26  THR A HA   1 
ATOM   372  H HB   . THR A 1 26  ? -7.93946  -37.66900 -0.59949  1.000 46.61342  ? 26  THR A HB   1 
ATOM   373  H HG1  . THR A 1 26  ? -8.55416  -39.31364 -2.01513  1.000 57.81604  ? 26  THR A HG1  1 
ATOM   374  H HG21 . THR A 1 26  ? -7.31136  -39.47722 0.96414   1.000 43.22468  ? 26  THR A HG21 1 
ATOM   375  H HG22 . THR A 1 26  ? -7.80625  -38.10344 1.56441   1.000 43.22468  ? 26  THR A HG22 1 
ATOM   376  H HG23 . THR A 1 26  ? -8.79884  -39.32764 1.47162   1.000 43.22468  ? 26  THR A HG23 1 
ATOM   377  N N    . LEU A 1 27  ? -10.92780 -37.57858 1.82850   1.000 31.40289  ? 27  LEU A N    1 
ATOM   378  C CA   . LEU A 1 27  ? -11.06598 -36.83790 3.08785   1.000 29.82245  ? 27  LEU A CA   1 
ATOM   379  C C    . LEU A 1 27  ? -11.12998 -37.81941 4.24662   1.000 29.48396  ? 27  LEU A C    1 
ATOM   380  O O    . LEU A 1 27  ? -10.81188 -39.00302 4.11078   1.000 29.38811  ? 27  LEU A O    1 
ATOM   381  C CB   . LEU A 1 27  ? -12.25826 -35.91316 2.96824   1.000 27.72505  ? 27  LEU A CB   1 
ATOM   382  C CG   . LEU A 1 27  ? -13.52733 -36.52030 2.42131   1.000 28.71902  ? 27  LEU A CG   1 
ATOM   383  C CD1  . LEU A 1 27  ? -14.14777 -37.55150 3.28090   1.000 32.17403  ? 27  LEU A CD1  1 
ATOM   384  C CD2  . LEU A 1 27  ? -14.46885 -35.35126 2.17742   1.000 30.80765  ? 27  LEU A CD2  1 
ATOM   385  H H    . LEU A 1 27  ? -11.30160 -38.35307 1.82227   1.000 37.73757  ? 27  LEU A H    1 
ATOM   386  H HA   . LEU A 1 27  ? -10.27539 -36.30182 3.25659   1.000 35.84105  ? 27  LEU A HA   1 
ATOM   387  H HB2  . LEU A 1 27  ? -12.46355 -35.57131 3.85249   1.000 33.32416  ? 27  LEU A HB2  1 
ATOM   388  H HB3  . LEU A 1 27  ? -12.01424 -35.18267 2.37855   1.000 33.32416  ? 27  LEU A HB3  1 
ATOM   389  H HG   . LEU A 1 27  ? -13.33194 -37.01342 1.60918   1.000 34.51692  ? 27  LEU A HG   1 
ATOM   390  H HD11 . LEU A 1 27  ? -14.14985 -37.23798 4.19883   1.000 38.66294  ? 27  LEU A HD11 1 
ATOM   391  H HD12 . LEU A 1 27  ? -15.05756 -37.70610 2.98210   1.000 38.66294  ? 27  LEU A HD12 1 
ATOM   392  H HD13 . LEU A 1 27  ? -13.63335 -38.37100 3.21242   1.000 38.66294  ? 27  LEU A HD13 1 
ATOM   393  H HD21 . LEU A 1 27  ? -14.02888 -34.70618 1.60193   1.000 37.02328  ? 27  LEU A HD21 1 
ATOM   394  H HD22 . LEU A 1 27  ? -15.27565 -35.67933 1.75041   1.000 37.02328  ? 27  LEU A HD22 1 
ATOM   395  H HD23 . LEU A 1 27  ? -14.68857 -34.93998 3.02799   1.000 37.02328  ? 27  LEU A HD23 1 
ATOM   396  N N    . ASN A 1 28  ? -11.50876 -37.32500 5.44600   1.000 27.19838  ? 28  ASN A N    1 
ATOM   397  C CA   . ASN A 1 28  ? -11.49471 -38.15126 6.64142   1.000 25.92776  ? 28  ASN A CA   1 
ATOM   398  C C    . ASN A 1 28  ? -12.88232 -38.67993 6.93365   1.000 29.20944  ? 28  ASN A C    1 
ATOM   399  O O    . ASN A 1 28  ? -13.87864 -38.05232 6.56666   1.000 27.03468  ? 28  ASN A O    1 
ATOM   400  C CB   . ASN A 1 28  ? -11.01788 -37.33706 7.84025   1.000 28.57821  ? 28  ASN A CB   1 
ATOM   401  C CG   . ASN A 1 28  ? -9.69772  -36.64392 7.57948   1.000 30.10328  ? 28  ASN A CG   1 
ATOM   402  O OD1  . ASN A 1 28  ? -8.64212  -37.25786 7.66687   1.000 31.44846  ? 28  ASN A OD1  1 
ATOM   403  N ND2  . ASN A 1 28  ? -9.75201  -35.35605 7.28494   1.000 30.81790  ? 28  ASN A ND2  1 
ATOM   404  H H    . ASN A 1 28  ? -11.77377 -36.51730 5.57636   1.000 32.69216  ? 28  ASN A H    1 
ATOM   405  H HA   . ASN A 1 28  ? -10.89714 -38.90305 6.50495   1.000 31.16741  ? 28  ASN A HA   1 
ATOM   406  H HB2  . ASN A 1 28  ? -11.67927 -36.65798 8.04596   1.000 34.34796  ? 28  ASN A HB2  1 
ATOM   407  H HB3  . ASN A 1 28  ? -10.90256 -37.92882 8.60013   1.000 34.34796  ? 28  ASN A HB3  1 
ATOM   408  H HD21 . ASN A 1 28  ? -9.02753  -34.91973 7.12886   1.000 37.03558  ? 28  ASN A HD21 1 
ATOM   409  H HD22 . ASN A 1 28  ? -10.51179 -34.95472 7.24944   1.000 37.03558  ? 28  ASN A HD22 1 
ATOM   410  N N    . GLY A 1 29  ? -12.93246 -39.85193 7.57759   1.000 27.36929  ? 29  GLY A N    1 
ATOM   411  C CA   . GLY A 1 29  ? -14.17744 -40.42422 8.00353   1.000 28.31830  ? 29  GLY A CA   1 
ATOM   412  C C    . GLY A 1 29  ? -14.03945 -40.75251 9.48178   1.000 28.47231  ? 29  GLY A C    1 
ATOM   413  O O    . GLY A 1 29  ? -12.92948 -40.87816 10.00987  1.000 25.93211  ? 29  GLY A O    1 
ATOM   414  H H    . GLY A 1 29  ? -12.24326 -40.32735 7.77397   1.000 32.89725  ? 29  GLY A H    1 
ATOM   415  H HA2  . GLY A 1 29  ? -14.90417 -39.79480 7.87474   1.000 34.03606  ? 29  GLY A HA2  1 
ATOM   416  H HA3  . GLY A 1 29  ? -14.36900 -41.23406 7.50516   1.000 34.03606  ? 29  GLY A HA3  1 
ATOM   417  N N    . LEU A 1 30  ? -15.17218 -40.88349 10.13280  1.000 27.22564  ? 30  LEU A N    1 
ATOM   418  C CA   . LEU A 1 30  ? -15.21324 -41.28797 11.53600  1.000 28.23833  ? 30  LEU A CA   1 
ATOM   419  C C    . LEU A 1 30  ? -15.81690 -42.67765 11.64189  1.000 25.95326  ? 30  LEU A C    1 
ATOM   420  O O    . LEU A 1 30  ? -16.96745 -42.87589 11.24750  1.000 29.80784  ? 30  LEU A O    1 
ATOM   421  C CB   . LEU A 1 30  ? -16.02678 -40.28629 12.34296  1.000 26.16763  ? 30  LEU A CB   1 
ATOM   422  C CG   . LEU A 1 30  ? -16.19679 -40.48016 13.86950  1.000 30.90359  ? 30  LEU A CG   1 
ATOM   423  C CD1  . LEU A 1 30  ? -14.91483 -40.08097 14.60815  1.000 32.16739  ? 30  LEU A CD1  1 
ATOM   424  C CD2  . LEU A 1 30  ? -17.40316 -39.73365 14.40528  1.000 28.28668  ? 30  LEU A CD2  1 
ATOM   425  H H    . LEU A 1 30  ? -15.94653 -40.74354 9.78581   1.000 32.72487  ? 30  LEU A H    1 
ATOM   426  H HA   . LEU A 1 30  ? -14.31231 -41.32862 11.89316  1.000 33.94010  ? 30  LEU A HA   1 
ATOM   427  H HB2  . LEU A 1 30  ? -15.61049 -39.41803 12.22576  1.000 31.45526  ? 30  LEU A HB2  1 
ATOM   428  H HB3  . LEU A 1 30  ? -16.92236 -40.27781 11.97045  1.000 31.45526  ? 30  LEU A HB3  1 
ATOM   429  H HG   . LEU A 1 30  ? -16.35938 -41.42084 14.04148  1.000 37.13841  ? 30  LEU A HG   1 
ATOM   430  H HD11 . LEU A 1 30  ? -14.15139 -40.26960 14.04028  1.000 38.65497  ? 30  LEU A HD11 1 
ATOM   431  H HD12 . LEU A 1 30  ? -14.94964 -39.13318 14.81153  1.000 38.65497  ? 30  LEU A HD12 1 
ATOM   432  H HD13 . LEU A 1 30  ? -14.85091 -40.59336 15.42929  1.000 38.65497  ? 30  LEU A HD13 1 
ATOM   433  H HD21 . LEU A 1 30  ? -17.30871 -39.62823 15.36490  1.000 33.99812  ? 30  LEU A HD21 1 
ATOM   434  H HD22 . LEU A 1 30  ? -17.45038 -38.86315 13.97994  1.000 33.99812  ? 30  LEU A HD22 1 
ATOM   435  H HD23 . LEU A 1 30  ? -18.20407 -40.24318 14.20573  1.000 33.99812  ? 30  LEU A HD23 1 
ATOM   436  N N    . TRP A 1 31  ? -15.04406 -43.61666 12.19342  1.000 29.41340  ? 31  TRP A N    1 
ATOM   437  C CA   . TRP A 1 31  ? -15.34251 -45.05109 12.23077  1.000 29.10594  ? 31  TRP A CA   1 
ATOM   438  C C    . TRP A 1 31  ? -15.76199 -45.43668 13.63924  1.000 31.43889  ? 31  TRP A C    1 
ATOM   439  O O    . TRP A 1 31  ? -14.94695 -45.42882 14.56377  1.000 33.52625  ? 31  TRP A O    1 
ATOM   440  C CB   . TRP A 1 31  ? -14.11992 -45.85422 11.79129  1.000 29.04664  ? 31  TRP A CB   1 
ATOM   441  C CG   . TRP A 1 31  ? -14.34200 -47.40223 11.70288  1.000 28.12143  ? 31  TRP A CG   1 
ATOM   442  C CD1  . TRP A 1 31  ? -15.53698 -48.07069 11.63517  1.000 33.22935  ? 31  TRP A CD1  1 
ATOM   443  C CD2  . TRP A 1 31  ? -13.32479 -48.39983 11.76230  1.000 37.41953  ? 31  TRP A CD2  1 
ATOM   444  N NE1  . TRP A 1 31  ? -15.30945 -49.44779 11.61998  1.000 34.98907  ? 31  TRP A NE1  1 
ATOM   445  C CE2  . TRP A 1 31  ? -13.95767 -49.66380 11.68889  1.000 32.68610  ? 31  TRP A CE2  1 
ATOM   446  C CE3  . TRP A 1 31  ? -11.94105 -48.35250 11.85815  1.000 33.56362  ? 31  TRP A CE3  1 
ATOM   447  C CZ2  . TRP A 1 31  ? -13.23948 -50.85141 11.69819  1.000 36.08376  ? 31  TRP A CZ2  1 
ATOM   448  C CZ3  . TRP A 1 31  ? -11.23107 -49.53125 11.85154  1.000 35.81058  ? 31  TRP A CZ3  1 
ATOM   449  C CH2  . TRP A 1 31  ? -11.88751 -50.77080 11.79287  1.000 34.46623  ? 31  TRP A CH2  1 
ATOM   450  H H    . TRP A 1 31  ? -14.29530 -43.43580 12.57584  1.000 35.35018  ? 31  TRP A H    1 
ATOM   451  H HA   . TRP A 1 31  ? -16.08477 -45.23939 11.63537  1.000 34.98123  ? 31  TRP A HA   1 
ATOM   452  H HB2  . TRP A 1 31  ? -13.85170 -45.54825 10.91076  1.000 34.91007  ? 31  TRP A HB2  1 
ATOM   453  H HB3  . TRP A 1 31  ? -13.40518 -45.69898 12.42842  1.000 34.91007  ? 31  TRP A HB3  1 
ATOM   454  H HD1  . TRP A 1 31  ? -16.37419 -47.66696 11.60401  1.000 39.92932  ? 31  TRP A HD1  1 
ATOM   455  H HE1  . TRP A 1 31  ? -15.91461 -50.05718 11.57501  1.000 42.04099  ? 31  TRP A HE1  1 
ATOM   456  H HE3  . TRP A 1 31  ? -11.50026 -47.53640 11.92583  1.000 40.33044  ? 31  TRP A HE3  1 
ATOM   457  H HZ2  . TRP A 1 31  ? -13.66951 -51.67406 11.64152  1.000 43.35462  ? 31  TRP A HZ2  1 
ATOM   458  H HZ3  . TRP A 1 31  ? -10.30206 -49.50637 11.88648  1.000 43.02679  ? 31  TRP A HZ3  1 
ATOM   459  H HH2  . TRP A 1 31  ? -11.38565 -51.55332 11.81943  1.000 41.41357  ? 31  TRP A HH2  1 
ATOM   460  N N    . LEU A 1 32  ? -17.03333 -45.73677 13.80506  1.000 30.04772  ? 32  LEU A N    1 
ATOM   461  C CA   . LEU A 1 32  ? -17.59614 -46.10383 15.09844  1.000 33.00171  ? 32  LEU A CA   1 
ATOM   462  C C    . LEU A 1 32  ? -18.46576 -47.32765 14.89598  1.000 34.68038  ? 32  LEU A C    1 
ATOM   463  O O    . LEU A 1 32  ? -19.27931 -47.34818 13.97399  1.000 32.67453  ? 32  LEU A O    1 
ATOM   464  C CB   . LEU A 1 32  ? -18.42056 -44.98691 15.69306  1.000 30.67161  ? 32  LEU A CB   1 
ATOM   465  C CG   . LEU A 1 32  ? -17.70408 -43.65399 15.98205  1.000 33.24210  ? 32  LEU A CG   1 
ATOM   466  C CD1  . LEU A 1 32  ? -18.77838 -42.59557 15.95882  1.000 30.99735  ? 32  LEU A CD1  1 
ATOM   467  C CD2  . LEU A 1 32  ? -16.96854 -43.71879 17.30387  1.000 36.76257  ? 32  LEU A CD2  1 
ATOM   468  H H    . LEU A 1 32  ? -17.61132 -45.73647 13.16824  1.000 36.11136  ? 32  LEU A H    1 
ATOM   469  H HA   . LEU A 1 32  ? -16.87999 -46.30696 15.72035  1.000 39.65615  ? 32  LEU A HA   1 
ATOM   470  H HB2  . LEU A 1 32  ? -19.14276 -44.79002 15.07617  1.000 36.86003  ? 32  LEU A HB2  1 
ATOM   471  H HB3  . LEU A 1 32  ? -18.78139 -45.30096 16.53691  1.000 36.86003  ? 32  LEU A HB3  1 
ATOM   472  H HG   . LEU A 1 32  ? -17.02095 -43.44299 15.32652  1.000 39.94462  ? 32  LEU A HG   1 
ATOM   473  H HD11 . LEU A 1 32  ? -19.14059 -42.53290 15.06117  1.000 37.25092  ? 32  LEU A HD11 1 
ATOM   474  H HD12 . LEU A 1 32  ? -19.47935 -42.84337 16.58182  1.000 37.25092  ? 32  LEU A HD12 1 
ATOM   475  H HD13 . LEU A 1 32  ? -18.38998 -41.74562 16.21888  1.000 37.25092  ? 32  LEU A HD13 1 
ATOM   476  H HD21 . LEU A 1 32  ? -16.23595 -43.08320 17.28911  1.000 44.16918  ? 32  LEU A HD21 1 
ATOM   477  H HD22 . LEU A 1 32  ? -17.58472 -43.49677 18.01936  1.000 44.16918  ? 32  LEU A HD22 1 
ATOM   478  H HD23 . LEU A 1 32  ? -16.62472 -44.61697 17.43024  1.000 44.16918  ? 32  LEU A HD23 1 
ATOM   479  N N    . ASP A 1 33  ? -18.30404 -48.34179 15.74418  1.000 40.35965  ? 33  ASP A N    1 
ATOM   480  C CA   . ASP A 1 33  ? -18.98565 -49.60819 15.46430  1.000 35.57119  ? 33  ASP A CA   1 
ATOM   481  C C    . ASP A 1 33  ? -18.67646 -49.96842 14.01239  1.000 35.05785  ? 33  ASP A C    1 
ATOM   482  O O    . ASP A 1 33  ? -17.54273 -49.79893 13.57055  1.000 33.69383  ? 33  ASP A O    1 
ATOM   483  C CB   . ASP A 1 33  ? -20.48040 -49.48900 15.75890  1.000 40.09852  ? 33  ASP A CB   1 
ATOM   484  C CG   . ASP A 1 33  ? -20.75017 -49.14356 17.22200  1.000 47.85856  ? 33  ASP A CG   1 
ATOM   485  O OD1  . ASP A 1 33  ? -19.89633 -49.48315 18.05677  1.000 44.83447  ? 33  ASP A OD1  1 
ATOM   486  O OD2  . ASP A 1 33  ? -21.77672 -48.51895 17.54917  1.000 43.07246  ? 33  ASP A OD2  1 
ATOM   487  H H    . ASP A 1 33  ? -17.82569 -48.32418 16.45866  1.000 48.48569  ? 33  ASP A H    1 
ATOM   488  H HA   . ASP A 1 33  ? -18.68149 -50.33134 16.03478  1.000 42.73953  ? 33  ASP A HA   1 
ATOM   489  H HB2  . ASP A 1 33  ? -20.85921 -48.78700 15.20699  1.000 48.17232  ? 33  ASP A HB2  1 
ATOM   490  H HB3  . ASP A 1 33  ? -20.91256 -50.33493 15.56262  1.000 48.17232  ? 33  ASP A HB3  1 
ATOM   491  N N    . ASP A 1 34  ? -19.65505 -50.44354 13.24716  1.000 38.69363  ? 34  ASP A N    1 
ATOM   492  C CA   . ASP A 1 34  ? -19.39137 -50.83229 11.85879  1.000 34.46623  ? 34  ASP A CA   1 
ATOM   493  C C    . ASP A 1 34  ? -19.88610 -49.79799 10.86368  1.000 38.83693  ? 34  ASP A C    1 
ATOM   494  O O    . ASP A 1 34  ? -20.31404 -50.10539 9.75261   1.000 35.87787  ? 34  ASP A O    1 
ATOM   495  C CB   . ASP A 1 34  ? -19.98523 -52.21580 11.57882  1.000 38.99125  ? 34  ASP A CB   1 
ATOM   496  C CG   . ASP A 1 34  ? -21.49390 -52.28850 11.80047  1.000 48.97711  ? 34  ASP A CG   1 
ATOM   497  O OD1  . ASP A 1 34  ? -22.11775 -51.27793 12.20992  1.000 41.71475  ? 34  ASP A OD1  1 
ATOM   498  O OD2  . ASP A 1 34  ? -22.06856 -53.38068 11.52994  1.000 43.91686  ? 34  ASP A OD2  1 
ATOM   499  H H    . ASP A 1 34  ? -20.46902 -50.54928 13.50382  1.000 46.48646  ? 34  ASP A H    1 
ATOM   500  H HA   . ASP A 1 34  ? -18.43193 -50.89757 11.73180  1.000 41.41358  ? 34  ASP A HA   1 
ATOM   501  H HB2  . ASP A 1 34  ? -19.80973 -52.45047 10.65414  1.000 46.84360  ? 34  ASP A HB2  1 
ATOM   502  H HB3  . ASP A 1 34  ? -19.56722 -52.86131 12.16999  1.000 46.84360  ? 34  ASP A HB3  1 
ATOM   503  N N    . VAL A 1 35  ? -19.77036 -48.52561 11.20238  1.000 34.36700  ? 35  VAL A N    1 
ATOM   504  C CA   . VAL A 1 35  ? -20.26629 -47.46267 10.35213  1.000 29.72255  ? 35  VAL A CA   1 
ATOM   505  C C    . VAL A 1 35  ? -19.16162 -46.42300 10.22139  1.000 29.05049  ? 35  VAL A C    1 
ATOM   506  O O    . VAL A 1 35  ? -18.49757 -46.09286 11.21003  1.000 32.15284  ? 35  VAL A O    1 
ATOM   507  C CB   . VAL A 1 35  ? -21.53835 -46.80059 10.90809  1.000 34.85381  ? 35  VAL A CB   1 
ATOM   508  C CG1  . VAL A 1 35  ? -21.94236 -45.64226 9.98692   1.000 33.19481  ? 35  VAL A CG1  1 
ATOM   509  C CG2  . VAL A 1 35  ? -22.61875 -47.81828 11.05920  1.000 33.83567  ? 35  VAL A CG2  1 
ATOM   510  H H    . VAL A 1 35  ? -19.40310 -48.25108 11.92994  1.000 41.29450  ? 35  VAL A H    1 
ATOM   511  H HA   . VAL A 1 35  ? -20.47997 -47.83244 9.48120   1.000 35.72116  ? 35  VAL A HA   1 
ATOM   512  H HB   . VAL A 1 35  ? -21.37996 -46.43176 11.79114  1.000 41.87867  ? 35  VAL A HB   1 
ATOM   513  H HG11 . VAL A 1 35  ? -22.87873 -45.43496 10.13233  1.000 39.88787  ? 35  VAL A HG11 1 
ATOM   514  H HG12 . VAL A 1 35  ? -21.39605 -44.86815 10.19479  1.000 39.88787  ? 35  VAL A HG12 1 
ATOM   515  H HG13 . VAL A 1 35  ? -21.80181 -45.90832 9.06478   1.000 39.88787  ? 35  VAL A HG13 1 
ATOM   516  H HG21 . VAL A 1 35  ? -23.42274 -47.38016 11.37945  1.000 40.65690  ? 35  VAL A HG21 1 
ATOM   517  H HG22 . VAL A 1 35  ? -22.78742 -48.23014 10.19733  1.000 40.65690  ? 35  VAL A HG22 1 
ATOM   518  H HG23 . VAL A 1 35  ? -22.33218 -48.49080 11.69677  1.000 40.65690  ? 35  VAL A HG23 1 
ATOM   519  N N    . VAL A 1 36  ? -18.95256 -45.91957 9.00932   1.000 31.26660  ? 36  VAL A N    1 
ATOM   520  C CA   . VAL A 1 36  ? -17.98918 -44.84380 8.79938   1.000 31.83862  ? 36  VAL A CA   1 
ATOM   521  C C    . VAL A 1 36  ? -18.76812 -43.63449 8.29782   1.000 31.51461  ? 36  VAL A C    1 
ATOM   522  O O    . VAL A 1 36  ? -19.45455 -43.71133 7.26613   1.000 30.37372  ? 36  VAL A O    1 
ATOM   523  C CB   . VAL A 1 36  ? -16.87927 -45.22165 7.81595   1.000 29.37932  ? 36  VAL A CB   1 
ATOM   524  C CG1  . VAL A 1 36  ? -15.99822 -43.95287 7.54331   1.000 27.54605  ? 36  VAL A CG1  1 
ATOM   525  C CG2  . VAL A 1 36  ? -16.00040 -46.36636 8.33310   1.000 25.41122  ? 36  VAL A CG2  1 
ATOM   526  H H    . VAL A 1 36  ? -19.35503 -46.18376 8.29671   1.000 37.57402  ? 36  VAL A H    1 
ATOM   527  H HA   . VAL A 1 36  ? -17.56723 -44.62665 9.64537   1.000 38.26044  ? 36  VAL A HA   1 
ATOM   528  H HB   . VAL A 1 36  ? -17.28915 -45.53640 6.99508   1.000 35.30928  ? 36  VAL A HB   1 
ATOM   529  H HG11 . VAL A 1 36  ? -15.19826 -44.22082 7.06460   1.000 33.10936  ? 36  VAL A HG11 1 
ATOM   530  H HG12 . VAL A 1 36  ? -16.50781 -43.32328 7.00961   1.000 33.10936  ? 36  VAL A HG12 1 
ATOM   531  H HG13 . VAL A 1 36  ? -15.75645 -43.54818 8.39106   1.000 33.10936  ? 36  VAL A HG13 1 
ATOM   532  H HG21 . VAL A 1 36  ? -15.28036 -45.99538 8.86677   1.000 30.54757  ? 36  VAL A HG21 1 
ATOM   533  H HG22 . VAL A 1 36  ? -16.54234 -46.96017 8.87586   1.000 30.54757  ? 36  VAL A HG22 1 
ATOM   534  H HG23 . VAL A 1 36  ? -15.63537 -46.85096 7.57625   1.000 30.54757  ? 36  VAL A HG23 1 
ATOM   535  N N    . TYR A 1 37  ? -18.67045 -42.51142 9.03083   1.000 31.82774  ? 37  TYR A N    1 
ATOM   536  C CA   . TYR A 1 37  ? -19.36806 -41.26661 8.70701   1.000 31.26928  ? 37  TYR A CA   1 
ATOM   537  C C    . TYR A 1 37  ? -18.43126 -40.30288 8.00084   1.000 25.09634  ? 37  TYR A C    1 
ATOM   538  O O    . TYR A 1 37  ? -17.30592 -40.10734 8.45768   1.000 30.06022  ? 37  TYR A O    1 
ATOM   539  C CB   . TYR A 1 37  ? -19.87131 -40.60078 9.99987   1.000 26.83153  ? 37  TYR A CB   1 
ATOM   540  C CG   . TYR A 1 37  ? -20.70673 -41.49514 10.84143  1.000 28.36248  ? 37  TYR A CG   1 
ATOM   541  C CD1  . TYR A 1 37  ? -20.13378 -42.45066 11.67206  1.000 31.99004  ? 37  TYR A CD1  1 
ATOM   542  C CD2  . TYR A 1 37  ? -22.09370 -41.40160 10.80860  1.000 25.72909  ? 37  TYR A CD2  1 
ATOM   543  C CE1  . TYR A 1 37  ? -20.90720 -43.28510 12.41954  1.000 32.66588  ? 37  TYR A CE1  1 
ATOM   544  C CE2  . TYR A 1 37  ? -22.87487 -42.26230 11.58198  1.000 29.94518  ? 37  TYR A CE2  1 
ATOM   545  C CZ   . TYR A 1 37  ? -22.26592 -43.19331 12.37040  1.000 29.85500  ? 37  TYR A CZ   1 
ATOM   546  O OH   . TYR A 1 37  ? -22.98452 -44.10751 13.14446  1.000 34.27218  ? 37  TYR A OH   1 
ATOM   547  H H    . TYR A 1 37  ? -18.18965 -42.45016 9.74124   1.000 38.24739  ? 37  TYR A H    1 
ATOM   548  H HA   . TYR A 1 37  ? -20.11142 -41.46461 8.11616   1.000 37.57723  ? 37  TYR A HA   1 
ATOM   549  H HB2  . TYR A 1 37  ? -19.10584 -40.32545 10.52821  1.000 32.25194  ? 37  TYR A HB2  1 
ATOM   550  H HB3  . TYR A 1 37  ? -20.40774 -39.82750 9.76499   1.000 32.25194  ? 37  TYR A HB3  1 
ATOM   551  H HD1  . TYR A 1 37  ? -19.20759 -42.52115 11.71799  1.000 38.44215  ? 37  TYR A HD1  1 
ATOM   552  H HD2  . TYR A 1 37  ? -22.50242 -40.76342 10.26955  1.000 30.92901  ? 37  TYR A HD2  1 
ATOM   553  H HE1  . TYR A 1 37  ? -20.50613 -43.92123 12.96669  1.000 39.25316  ? 37  TYR A HE1  1 
ATOM   554  H HE2  . TYR A 1 37  ? -23.80259 -42.20116 11.55961  1.000 35.98832  ? 37  TYR A HE2  1 
ATOM   555  H HH   . TYR A 1 37  ? -23.79702 -43.89490 13.15974  1.000 41.18072  ? 37  TYR A HH   1 
ATOM   556  N N    . CYS A 1 38  ? -18.87461 -39.67052 6.91184   1.000 28.12032  ? 38  CYS A N    1 
ATOM   557  C CA   . CYS A 1 38  ? -18.02867 -38.65631 6.28033   1.000 32.24396  ? 38  CYS A CA   1 
ATOM   558  C C    . CYS A 1 38  ? -18.90171 -37.64899 5.52395   1.000 28.30664  ? 38  CYS A C    1 
ATOM   559  O O    . CYS A 1 38  ? -20.08516 -37.86908 5.30837   1.000 30.72606  ? 38  CYS A O    1 
ATOM   560  C CB   . CYS A 1 38  ? -16.99755 -39.29491 5.35508   1.000 36.69427  ? 38  CYS A CB   1 
ATOM   561  S SG   . CYS A 1 38  ? -17.68496 -40.02213 3.80239   1.000 30.91354  ? 38  CYS A SG   1 
ATOM   562  H H    . CYS A 1 38  ? -19.63488 -39.80684 6.53368   1.000 33.79848  ? 38  CYS A H    1 
ATOM   563  H HA   . CYS A 1 38  ? -17.56317 -38.16102 6.97235   1.000 38.74685  ? 38  CYS A HA   1 
ATOM   564  H HB2  . CYS A 1 38  ? -16.35390 -38.61622 5.09820   1.000 44.08723  ? 38  CYS A HB2  1 
ATOM   565  H HB3  . CYS A 1 38  ? -16.55225 -40.00855 5.83812   1.000 44.08723  ? 38  CYS A HB3  1 
ATOM   566  H HG   . CYS A 1 38  ? -18.04525 -39.13350 3.08091   1.000 37.15035  ? 38  CYS A HG   1 
ATOM   567  N N    . PRO A 1 39  ? -18.30369 -36.52133 5.14905   1.000 26.18286  ? 39  PRO A N    1 
ATOM   568  C CA   . PRO A 1 39  ? -19.05757 -35.52881 4.36465   1.000 25.51272  ? 39  PRO A CA   1 
ATOM   569  C C    . PRO A 1 39  ? -19.43406 -36.09309 3.00951   1.000 27.46170  ? 39  PRO A C    1 
ATOM   570  O O    . PRO A 1 39  ? -18.63900 -36.76337 2.34758   1.000 31.57980  ? 39  PRO A O    1 
ATOM   571  C CB   . PRO A 1 39  ? -18.07668 -34.35723 4.24019   1.000 28.76554  ? 39  PRO A CB   1 
ATOM   572  C CG   . PRO A 1 39  ? -17.01946 -34.58755 5.28003   1.000 34.26491  ? 39  PRO A CG   1 
ATOM   573  C CD   . PRO A 1 39  ? -16.92312 -36.11736 5.35911   1.000 28.49288  ? 39  PRO A CD   1 
ATOM   574  H HA   . PRO A 1 39  ? -19.85352 -35.23636 4.83566   1.000 30.66936  ? 39  PRO A HA   1 
ATOM   575  H HB2  . PRO A 1 39  ? -17.68817 -34.35077 3.35142   1.000 34.57275  ? 39  PRO A HB2  1 
ATOM   576  H HB3  . PRO A 1 39  ? -18.54340 -33.52288 4.40432   1.000 34.57275  ? 39  PRO A HB3  1 
ATOM   577  H HG2  . PRO A 1 39  ? -16.17825 -34.19577 4.99759   1.000 41.17199  ? 39  PRO A HG2  1 
ATOM   578  H HG3  . PRO A 1 39  ? -17.29387 -34.20753 6.12926   1.000 41.17199  ? 39  PRO A HG3  1 
ATOM   579  H HD2  . PRO A 1 39  ? -16.34633 -36.46789 4.66244   1.000 34.24556  ? 39  PRO A HD2  1 
ATOM   580  H HD3  . PRO A 1 39  ? -16.60368 -36.40311 6.22928   1.000 34.24556  ? 39  PRO A HD3  1 
ATOM   581  N N    . ARG A 1 40  ? -20.67372 -35.83273 2.60371   1.000 29.53429  ? 40  ARG A N    1 
ATOM   582  C CA   . ARG A 1 40  ? -21.12746 -36.39506 1.33987   1.000 29.62358  ? 40  ARG A CA   1 
ATOM   583  C C    . ARG A 1 40  ? -20.39489 -35.79782 0.13517   1.000 32.29203  ? 40  ARG A C    1 
ATOM   584  O O    . ARG A 1 40  ? -20.39271 -36.42399 -0.91121  1.000 31.81652  ? 40  ARG A O    1 
ATOM   585  C CB   . ARG A 1 40  ? -22.64985 -36.21221 1.19234   1.000 31.28491  ? 40  ARG A CB   1 
ATOM   586  C CG   . ARG A 1 40  ? -23.12683 -34.76091 1.08511   1.000 29.94833  ? 40  ARG A CG   1 
ATOM   587  C CD   . ARG A 1 40  ? -24.60459 -34.75374 0.83165   1.000 30.13554  ? 40  ARG A CD   1 
ATOM   588  N NE   . ARG A 1 40  ? -25.11625 -33.40556 0.72748   1.000 28.77102  ? 40  ARG A NE   1 
ATOM   589  C CZ   . ARG A 1 40  ? -26.37964 -33.09283 0.50210   1.000 33.75641  ? 40  ARG A CZ   1 
ATOM   590  N NH1  . ARG A 1 40  ? -27.29294 -34.02479 0.30210   1.000 33.66249  ? 40  ARG A NH1  1 
ATOM   591  N NH2  . ARG A 1 40  ? -26.73898 -31.81032 0.49469   1.000 33.34935  ? 40  ARG A NH2  1 
ATOM   592  H H    . ARG A 1 40  ? -21.24832 -35.35209 3.02610   1.000 35.49525  ? 40  ARG A H    1 
ATOM   593  H HA   . ARG A 1 40  ? -20.94782 -37.34828 1.34240   1.000 35.60240  ? 40  ARG A HA   1 
ATOM   594  H HB2  . ARG A 1 40  ? -22.93652 -36.67150 0.38749   1.000 37.59599  ? 40  ARG A HB2  1 
ATOM   595  H HB3  . ARG A 1 40  ? -23.08143 -36.60232 1.96852   1.000 37.59599  ? 40  ARG A HB3  1 
ATOM   596  H HG2  . ARG A 1 40  ? -22.94626 -34.29075 1.91411   1.000 35.99210  ? 40  ARG A HG2  1 
ATOM   597  H HG3  . ARG A 1 40  ? -22.67779 -34.31821 0.34804   1.000 35.99210  ? 40  ARG A HG3  1 
ATOM   598  H HD2  . ARG A 1 40  ? -24.79010 -35.21590 -0.00075  1.000 36.21674  ? 40  ARG A HD2  1 
ATOM   599  H HD3  . ARG A 1 40  ? -25.05864 -35.19680 1.56543   1.000 36.21674  ? 40  ARG A HD3  1 
ATOM   600  H HE   . ARG A 1 40  ? -24.55643 -32.75918 0.81906   1.000 34.57932  ? 40  ARG A HE   1 
ATOM   601  H HH11 . ARG A 1 40  ? -27.07023 -34.85532 0.31701   1.000 40.44909  ? 40  ARG A HH11 1 
ATOM   602  H HH12 . ARG A 1 40  ? -28.11063 -33.80141 0.15691   1.000 40.44909  ? 40  ARG A HH12 1 
ATOM   603  H HH21 . ARG A 1 40  ? -26.15142 -31.19831 0.63549   1.000 40.07332  ? 40  ARG A HH21 1 
ATOM   604  H HH22 . ARG A 1 40  ? -27.55856 -31.59423 0.34912   1.000 40.07332  ? 40  ARG A HH22 1 
ATOM   605  N N    . HIS A 1 41  ? -19.74803 -34.61985 0.24650   1.000 27.10774  ? 41  HIS A N    1 
ATOM   606  C CA   . HIS A 1 41  ? -19.05949 -34.11984 -0.93453  1.000 32.95520  ? 41  HIS A CA   1 
ATOM   607  C C    . HIS A 1 41  ? -17.80155 -34.92995 -1.26772  1.000 28.74379  ? 41  HIS A C    1 
ATOM   608  O O    . HIS A 1 41  ? -17.10082 -34.55431 -2.23093  1.000 34.02345  ? 41  HIS A O    1 
ATOM   609  C CB   . HIS A 1 41  ? -18.75903 -32.61811 -0.81143  1.000 26.66956  ? 41  HIS A CB   1 
ATOM   610  C CG   . HIS A 1 41  ? -17.64633 -32.25130 0.13567   1.000 29.41902  ? 41  HIS A CG   1 
ATOM   611  N ND1  . HIS A 1 41  ? -17.88302 -31.72290 1.38171   1.000 30.93838  ? 41  HIS A ND1  1 
ATOM   612  C CD2  . HIS A 1 41  ? -16.30041 -32.25400 -0.02481  1.000 31.13642  ? 41  HIS A CD2  1 
ATOM   613  C CE1  . HIS A 1 41  ? -16.72243 -31.42908 1.95996   1.000 29.02799  ? 41  HIS A CE1  1 
ATOM   614  N NE2  . HIS A 1 41  ? -15.74874 -31.75880 1.13384   1.000 31.75800  ? 41  HIS A NE2  1 
ATOM   615  H H    . HIS A 1 41  ? -19.70342 -34.13275 0.95385   1.000 32.58339  ? 41  HIS A H    1 
ATOM   616  H HA   . HIS A 1 41  ? -19.65511 -34.19811 -1.69611  1.000 39.60034  ? 41  HIS A HA   1 
ATOM   617  H HB2  . HIS A 1 41  ? -18.51284 -32.28393 -1.68814  1.000 32.05757  ? 41  HIS A HB2  1 
ATOM   618  H HB3  . HIS A 1 41  ? -19.56163 -32.17152 -0.49952  1.000 32.05757  ? 41  HIS A HB3  1 
ATOM   619  H HD2  . HIS A 1 41  ? -15.83591 -32.53809 -0.77876  1.000 37.41780  ? 41  HIS A HD2  1 
ATOM   620  H HE1  . HIS A 1 41  ? -16.61533 -31.05434 2.80435   1.000 34.88769  ? 41  HIS A HE1  1 
ATOM   621  H HE2  . HIS A 1 41  ? -14.90755 -31.67758 1.29325   1.000 38.16370  ? 41  HIS A HE2  1 
ATOM   622  N N    . VAL A 1 42  ? -17.53811 -36.03680 -0.57800  1.000 29.63356  ? 42  VAL A N    1 
ATOM   623  C CA   . VAL A 1 42  ? -16.46814 -36.91639 -1.04173  1.000 32.37931  ? 42  VAL A CA   1 
ATOM   624  C C    . VAL A 1 42  ? -16.79404 -37.47884 -2.42465  1.000 39.59631  ? 42  VAL A C    1 
ATOM   625  O O    . VAL A 1 42  ? -15.88491 -37.94299 -3.14611  1.000 33.62220  ? 42  VAL A O    1 
ATOM   626  C CB   . VAL A 1 42  ? -16.18176 -38.05081 -0.07149  1.000 27.86428  ? 42  VAL A CB   1 
ATOM   627  C CG1  . VAL A 1 42  ? -17.29924 -39.08692 -0.02173  1.000 29.16743  ? 42  VAL A CG1  1 
ATOM   628  C CG2  . VAL A 1 42  ? -14.79682 -38.71554 -0.36298  1.000 30.97008  ? 42  VAL A CG2  1 
ATOM   629  H H    . VAL A 1 42  ? -17.94778 -36.29177 0.13387   1.000 35.61437  ? 42  VAL A H    1 
ATOM   630  H HA   . VAL A 1 42  ? -15.66103 -36.38020 -1.08616  1.000 38.90927  ? 42  VAL A HA   1 
ATOM   631  H HB   . VAL A 1 42  ? -16.14075 -37.65791 0.81442   1.000 33.49124  ? 42  VAL A HB   1 
ATOM   632  H HG11 . VAL A 1 42  ? -18.14895 -38.63031 0.08030   1.000 35.05502  ? 42  VAL A HG11 1 
ATOM   633  H HG12 . VAL A 1 42  ? -17.29452 -39.59639 -0.84715  1.000 35.05502  ? 42  VAL A HG12 1 
ATOM   634  H HG13 . VAL A 1 42  ? -17.14862 -39.67787 0.73259   1.000 35.05502  ? 42  VAL A HG13 1 
ATOM   635  H HG21 . VAL A 1 42  ? -14.90318 -39.67969 -0.36362  1.000 37.21820  ? 42  VAL A HG21 1 
ATOM   636  H HG22 . VAL A 1 42  ? -14.47949 -38.41719 -1.22969  1.000 37.21820  ? 42  VAL A HG22 1 
ATOM   637  H HG23 . VAL A 1 42  ? -14.16865 -38.45251 0.32776   1.000 37.21820  ? 42  VAL A HG23 1 
ATOM   638  N N    . ILE A 1 43  ? -18.07098 -37.46265 -2.81980  1.000 31.86581  ? 43  ILE A N    1 
ATOM   639  C CA   . ILE A 1 43  ? -18.42249 -38.02454 -4.13600  1.000 35.93405  ? 43  ILE A CA   1 
ATOM   640  C C    . ILE A 1 43  ? -18.29687 -37.02810 -5.27566  1.000 43.02995  ? 43  ILE A C    1 
ATOM   641  O O    . ILE A 1 43  ? -18.40404 -37.41676 -6.45463  1.000 38.69479  ? 43  ILE A O    1 
ATOM   642  C CB   . ILE A 1 43  ? -19.85209 -38.61529 -4.14656  1.000 35.02225  ? 43  ILE A CB   1 
ATOM   643  C CG1  . ILE A 1 43  ? -20.91636 -37.51070 -4.08493  1.000 36.66165  ? 43  ILE A CG1  1 
ATOM   644  C CG2  . ILE A 1 43  ? -19.99251 -39.64920 -3.05267  1.000 36.31717  ? 43  ILE A CG2  1 
ATOM   645  C CD1  . ILE A 1 43  ? -22.35296 -38.04353 -4.11471  1.000 38.70923  ? 43  ILE A CD1  1 
ATOM   646  H H    . ILE A 1 43  ? -18.72852 -37.14560 -2.36514  1.000 38.29308  ? 43  ILE A H    1 
ATOM   647  H HA   . ILE A 1 43  ? -17.79297 -38.74380 -4.30116  1.000 43.17496  ? 43  ILE A HA   1 
ATOM   648  H HB   . ILE A 1 43  ? -20.00048 -39.07007 -4.99040  1.000 42.08080  ? 43  ILE A HB   1 
ATOM   649  H HG12 . ILE A 1 43  ? -20.80168 -37.01141 -3.26124  1.000 44.04808  ? 43  ILE A HG12 1 
ATOM   650  H HG13 . ILE A 1 43  ? -20.80165 -36.92284 -4.84793  1.000 44.04808  ? 43  ILE A HG13 1 
ATOM   651  H HG21 . ILE A 1 43  ? -19.89983 -39.21243 -2.19154  1.000 43.63471  ? 43  ILE A HG21 1 
ATOM   652  H HG22 . ILE A 1 43  ? -20.86660 -40.06421 -3.12070  1.000 43.63471  ? 43  ILE A HG22 1 
ATOM   653  H HG23 . ILE A 1 43  ? -19.29910 -40.31891 -3.16022  1.000 43.63471  ? 43  ILE A HG23 1 
ATOM   654  H HD11 . ILE A 1 43  ? -22.96838 -37.29500 -4.07151  1.000 46.50518  ? 43  ILE A HD11 1 
ATOM   655  H HD12 . ILE A 1 43  ? -22.48972 -38.53708 -4.93849  1.000 46.50518  ? 43  ILE A HD12 1 
ATOM   656  H HD13 . ILE A 1 43  ? -22.48890 -38.62792 -3.35253  1.000 46.50518  ? 43  ILE A HD13 1 
ATOM   657  N N    . CYS A 1 44  ? -18.03716 -35.76729 -4.98642  1.000 33.95435  ? 44  CYS A N    1 
ATOM   658  C CA   . CYS A 1 44  ? -17.99027 -34.75591 -6.02067  1.000 36.29205  ? 44  CYS A CA   1 
ATOM   659  C C    . CYS A 1 44  ? -16.61468 -34.70530 -6.67150  1.000 43.04042  ? 44  CYS A C    1 
ATOM   660  O O    . CYS A 1 44  ? -15.58601 -34.87340 -6.00631  1.000 42.08372  ? 44  CYS A O    1 
ATOM   661  C CB   . CYS A 1 44  ? -18.29250 -33.36934 -5.45842  1.000 41.32808  ? 44  CYS A CB   1 
ATOM   662  S SG   . CYS A 1 44  ? -19.89328 -33.18028 -4.70788  1.000 39.76364  ? 44  CYS A SG   1 
ATOM   663  H H    . CYS A 1 44  ? -17.88368 -35.47042 -4.19401  1.000 40.79932  ? 44  CYS A H    1 
ATOM   664  H HA   . CYS A 1 44  ? -18.65950 -34.98314 -6.68504  1.000 43.60456  ? 44  CYS A HA   1 
ATOM   665  H HB2  . CYS A 1 44  ? -17.62966 -33.16395 -4.78066  1.000 49.64779  ? 44  CYS A HB2  1 
ATOM   666  H HB3  . CYS A 1 44  ? -18.23573 -32.72729 -6.18330  1.000 49.64779  ? 44  CYS A HB3  1 
ATOM   667  H HG   . CYS A 1 44  ? -20.08800 -32.01624 -4.49084  1.000 47.77047  ? 44  CYS A HG   1 
ATOM   668  N N    . THR A 1 45  ? -16.60694 -34.43790 -7.96729  1.000 40.52196  ? 45  THR A N    1 
ATOM   669  C CA   . THR A 1 45  ? -15.40600 -33.94048 -8.61369  1.000 47.35205  ? 45  THR A CA   1 
ATOM   670  C C    . THR A 1 45  ? -15.31319 -32.43068 -8.41068  1.000 57.31754  ? 45  THR A C    1 
ATOM   671  O O    . THR A 1 45  ? -16.29161 -31.76996 -8.04514  1.000 53.60742  ? 45  THR A O    1 
ATOM   672  C CB   . THR A 1 45  ? -15.43911 -34.29957 -10.09552 1.000 49.55154  ? 45  THR A CB   1 
ATOM   673  O OG1  . THR A 1 45  ? -16.58576 -33.69882 -10.69948 1.000 51.04520  ? 45  THR A OG1  1 
ATOM   674  C CG2  . THR A 1 45  ? -15.53049 -35.80645 -10.25679 1.000 44.99676  ? 45  THR A CG2  1 
ATOM   675  H H    . THR A 1 45  ? -17.28130 -34.53565 -8.49197  1.000 48.68046  ? 45  THR A H    1 
ATOM   676  H HA   . THR A 1 45  ? -14.60871 -34.34155 -8.23374  1.000 56.87657  ? 45  THR A HA   1 
ATOM   677  H HB   . THR A 1 45  ? -14.63389 -33.98190 -10.53325 1.000 59.51595  ? 45  THR A HB   1 
ATOM   678  H HG1  . THR A 1 45  ? -16.46241 -32.87307 -10.79179 1.000 61.30834  ? 45  THR A HG1  1 
ATOM   679  H HG21 . THR A 1 45  ? -15.44088 -36.04601 -11.19246 1.000 54.05022  ? 45  THR A HG21 1 
ATOM   680  H HG22 . THR A 1 45  ? -14.82303 -36.23760 -9.75230  1.000 54.05022  ? 45  THR A HG22 1 
ATOM   681  H HG23 . THR A 1 45  ? -16.38747 -36.12357 -9.93132  1.000 54.05022  ? 45  THR A HG23 1 
ATOM   682  N N    . SER A 1 46  ? -14.11862 -31.87736 -8.63593  1.000 61.00797  ? 46  SER A N    1 
ATOM   683  C CA   . SER A 1 46  ? -13.95464 -30.44116 -8.40577  1.000 68.57244  ? 46  SER A CA   1 
ATOM   684  C C    . SER A 1 46  ? -14.97994 -29.63358 -9.19525  1.000 66.72229  ? 46  SER A C    1 
ATOM   685  O O    . SER A 1 46  ? -15.42070 -28.57165 -8.74043  1.000 58.22955  ? 46  SER A O    1 
ATOM   686  C CB   . SER A 1 46  ? -12.53115 -30.01360 -8.75173  1.000 71.35207  ? 46  SER A CB   1 
ATOM   687  O OG   . SER A 1 46  ? -11.61226 -30.66477 -7.89219  1.000 69.71479  ? 46  SER A OG   1 
ATOM   688  H H    . SER A 1 46  ? -13.41750 -32.29303 -8.91025  1.000 73.26366  ? 46  SER A H    1 
ATOM   689  H HA   . SER A 1 46  ? -14.09201 -30.25037 -7.46469  1.000 82.34103  ? 46  SER A HA   1 
ATOM   690  H HB2  . SER A 1 46  ? -12.33810 -30.25779 -9.67043  1.000 85.67659  ? 46  SER A HB2  1 
ATOM   691  H HB3  . SER A 1 46  ? -12.44921 -29.05362 -8.63939  1.000 85.67659  ? 46  SER A HB3  1 
ATOM   692  H HG   . SER A 1 46  ? -11.80557 -30.50454 -7.09060  1.000 83.71185  ? 46  SER A HG   1 
ATOM   693  N N    . GLU A 1 47  ? -15.40139 -30.14540 -10.35568 1.000 62.59594  ? 47  GLU A N    1 
ATOM   694  C CA   . GLU A 1 47  ? -16.43202 -29.48323 -11.15204 1.000 66.44341  ? 47  GLU A CA   1 
ATOM   695  C C    . GLU A 1 47  ? -17.81699 -29.60599 -10.51384 1.000 57.84574  ? 47  GLU A C    1 
ATOM   696  O O    . GLU A 1 47  ? -18.56787 -28.62244 -10.45415 1.000 58.57094  ? 47  GLU A O    1 
ATOM   697  C CB   . GLU A 1 47  ? -16.41681 -30.08111 -12.56020 1.000 68.61880  ? 47  GLU A CB   1 
ATOM   698  C CG   . GLU A 1 47  ? -17.69528 -29.89684 -13.34357 1.000 90.06990  ? 47  GLU A CG   1 
ATOM   699  C CD   . GLU A 1 47  ? -17.47482 -29.97425 -14.84673 1.000 100.64248 ? 47  GLU A CD   1 
ATOM   700  O OE1  . GLU A 1 47  ? -16.30524 -30.03314 -15.28265 1.000 106.38013 ? 47  GLU A OE1  1 
ATOM   701  O OE2  . GLU A 1 47  ? -18.47566 -29.97077 -15.59314 1.000 100.62878 ? 47  GLU A OE2  1 
ATOM   702  H H    . GLU A 1 47  ? -15.10599 -30.87465 -10.70286 1.000 75.16923  ? 47  GLU A H    1 
ATOM   703  H HA   . GLU A 1 47  ? -16.23765 -28.53469 -11.21019 1.000 79.78619  ? 47  GLU A HA   1 
ATOM   704  H HB2  . GLU A 1 47  ? -15.70294 -29.66081 -13.06481 1.000 82.39666  ? 47  GLU A HB2  1 
ATOM   705  H HB3  . GLU A 1 47  ? -16.25474 -31.03470 -12.48745 1.000 82.39666  ? 47  GLU A HB3  1 
ATOM   706  H HG2  . GLU A 1 47  ? -18.32236 -30.59397 -13.09523 1.000 108.13798 ? 47  GLU A HG2  1 
ATOM   707  H HG3  . GLU A 1 47  ? -18.06954 -29.02566 -13.13892 1.000 108.13798 ? 47  GLU A HG3  1 
ATOM   708  N N    . ASP A 1 48  ? -18.17248 -30.79163 -10.02940 1.000 50.09351  ? 48  ASP A N    1 
ATOM   709  C CA   . ASP A 1 48  ? -19.46110 -30.98956 -9.38270  1.000 50.09232  ? 48  ASP A CA   1 
ATOM   710  C C    . ASP A 1 48  ? -19.67778 -30.05035 -8.19773  1.000 48.86012  ? 48  ASP A C    1 
ATOM   711  O O    . ASP A 1 48  ? -20.82915 -29.83347 -7.78367  1.000 43.50386  ? 48  ASP A O    1 
ATOM   712  C CB   . ASP A 1 48  ? -19.58666 -32.42564 -8.86086  1.000 48.75391  ? 48  ASP A CB   1 
ATOM   713  C CG   . ASP A 1 48  ? -19.52002 -33.47720 -9.95565  1.000 50.81306  ? 48  ASP A CG   1 
ATOM   714  O OD1  . ASP A 1 48  ? -19.86090 -33.18318 -11.12338 1.000 56.22340  ? 48  ASP A OD1  1 
ATOM   715  O OD2  . ASP A 1 48  ? -19.14214 -34.61883 -9.62086  1.000 45.84059  ? 48  ASP A OD2  1 
ATOM   716  H H    . ASP A 1 48  ? -17.68405 -31.49868 -10.06292 1.000 60.16631  ? 48  ASP A H    1 
ATOM   717  H HA   . ASP A 1 48  ? -20.14427 -30.82611 -10.05163 1.000 60.16488  ? 48  ASP A HA   1 
ATOM   718  H HB2  . ASP A 1 48  ? -18.86159 -32.59761 -8.23989  1.000 58.55879  ? 48  ASP A HB2  1 
ATOM   719  H HB3  . ASP A 1 48  ? -20.43984 -32.52120 -8.40935  1.000 58.55879  ? 48  ASP A HB3  1 
ATOM   720  N N    . MET A 1 49  ? -18.61056 -29.52495 -7.60921  1.000 53.75130  ? 49  MET A N    1 
ATOM   721  C CA   . MET A 1 49  ? -18.77334 -28.82442 -6.33905  1.000 47.99445  ? 49  MET A CA   1 
ATOM   722  C C    . MET A 1 49  ? -19.42395 -27.45823 -6.49486  1.000 44.89116  ? 49  MET A C    1 
ATOM   723  O O    . MET A 1 49  ? -19.88734 -26.89858 -5.49830  1.000 39.99383  ? 49  MET A O    1 
ATOM   724  C CB   . MET A 1 49  ? -17.41302 -28.72468 -5.62658  1.000 52.21737  ? 49  MET A CB   1 
ATOM   725  C CG   . MET A 1 49  ? -16.91713 -30.09175 -5.08009  1.000 53.09520  ? 49  MET A CG   1 
ATOM   726  S SD   . MET A 1 49  ? -15.35733 -30.04375 -4.13522  1.000 57.71681  ? 49  MET A SD   1 
ATOM   727  C CE   . MET A 1 49  ? -15.04067 -31.78301 -3.81350  1.000 45.52649  ? 49  MET A CE   1 
ATOM   728  H H    . MET A 1 49  ? -17.80689 -29.55838 -7.91350  1.000 64.55566  ? 49  MET A H    1 
ATOM   729  H HA   . MET A 1 49  ? -19.35177 -29.34601 -5.76090  1.000 57.64744  ? 49  MET A HA   1 
ATOM   730  H HB2  . MET A 1 49  ? -16.75150 -28.39479 -6.25465  1.000 62.71495  ? 49  MET A HB2  1 
ATOM   731  H HB3  . MET A 1 49  ? -17.49330 -28.11342 -4.87770  1.000 62.71495  ? 49  MET A HB3  1 
ATOM   732  H HG2  . MET A 1 49  ? -17.59939 -30.45056 -4.49129  1.000 63.76834  ? 49  MET A HG2  1 
ATOM   733  H HG3  . MET A 1 49  ? -16.78000 -30.68923 -5.83183  1.000 63.76834  ? 49  MET A HG3  1 
ATOM   734  H HE1  . MET A 1 49  ? -15.07145 -32.26996 -4.65185  1.000 54.68589  ? 49  MET A HE1  1 
ATOM   735  H HE2  . MET A 1 49  ? -14.16354 -31.87487 -3.40963  1.000 54.68589  ? 49  MET A HE2  1 
ATOM   736  H HE3  . MET A 1 49  ? -15.72005 -32.12122 -3.20938  1.000 54.68589  ? 49  MET A HE3  1 
ATOM   737  N N    . LEU A 1 50  ? -19.54965 -26.92826 -7.70390  1.000 41.83038  ? 50  LEU A N    1 
ATOM   738  C CA   . LEU A 1 50  ? -20.17028 -25.61063 -7.82929  1.000 39.09525  ? 50  LEU A CA   1 
ATOM   739  C C    . LEU A 1 50  ? -21.68680 -25.67253 -7.67356  1.000 43.51335  ? 50  LEU A C    1 
ATOM   740  O O    . LEU A 1 50  ? -22.28829 -24.72941 -7.15772  1.000 46.33645  ? 50  LEU A O    1 
ATOM   741  C CB   . LEU A 1 50  ? -19.79445 -24.97802 -9.17618  1.000 50.00710  ? 50  LEU A CB   1 
ATOM   742  H H    . LEU A 1 50  ? -19.29531 -27.29319 -8.43993  1.000 50.25056  ? 50  LEU A H    1 
ATOM   743  H HA   . LEU A 1 50  ? -19.82757 -25.03540 -7.12746  1.000 46.96840  ? 50  LEU A HA   1 
ATOM   744  N N    . ASN A 1 51  ? -22.31860 -26.78872 -8.08028  1.000 46.22559  ? 51  ASN A N    1 
ATOM   745  C CA   . ASN A 1 51  ? -23.76345 -26.95559 -7.99770  1.000 52.16048  ? 51  ASN A CA   1 
ATOM   746  C C    . ASN A 1 51  ? -24.10574 -28.44519 -8.03572  1.000 44.77955  ? 51  ASN A C    1 
ATOM   747  O O    . ASN A 1 51  ? -24.65671 -28.95354 -9.02262  1.000 43.77984  ? 51  ASN A O    1 
ATOM   748  C CB   . ASN A 1 51  ? -24.46739 -26.22100 -9.13311  1.000 58.11079  ? 51  ASN A CB   1 
ATOM   749  C CG   . ASN A 1 51  ? -25.95912 -26.09289 -8.89795  1.000 67.78681  ? 51  ASN A CG   1 
ATOM   750  O OD1  . ASN A 1 51  ? -26.46290 -26.39371 -7.81209  1.000 57.91005  ? 51  ASN A OD1  1 
ATOM   751  N ND2  . ASN A 1 51  ? -26.67442 -25.63461 -9.91589  1.000 91.76876  ? 51  ASN A ND2  1 
ATOM   752  H H    . ASN A 1 51  ? -21.91620 -27.47204 -8.41307  1.000 55.52481  ? 51  ASN A H    1 
ATOM   753  H HA   . ASN A 1 51  ? -24.08193 -26.58090 -7.16159  1.000 62.64668  ? 51  ASN A HA   1 
ATOM   754  H HB2  . ASN A 1 51  ? -24.09653 -25.32819 -9.21215  1.000 69.78705  ? 51  ASN A HB2  1 
ATOM   755  H HB3  . ASN A 1 51  ? -24.33309 -26.71041 -9.95976  1.000 69.78705  ? 51  ASN A HB3  1 
ATOM   756  H HD21 . ASN A 1 51  ? -27.52574 -25.54236 -9.83621  1.000 110.17661 ? 51  ASN A HD21 1 
ATOM   757  H HD22 . ASN A 1 51  ? -26.28708 -25.42960 -10.65584 1.000 110.17661 ? 51  ASN A HD22 1 
ATOM   758  N N    . PRO A 1 52  ? -23.78367 -29.17384 -6.98060  1.000 37.55497  ? 52  PRO A N    1 
ATOM   759  C CA   . PRO A 1 52  ? -23.91134 -30.63529 -7.02521  1.000 37.31890  ? 52  PRO A CA   1 
ATOM   760  C C    . PRO A 1 52  ? -25.35375 -31.06700 -6.82651  1.000 41.31217  ? 52  PRO A C    1 
ATOM   761  O O    . PRO A 1 52  ? -26.08794 -30.50648 -6.01694  1.000 38.65333  ? 52  PRO A O    1 
ATOM   762  C CB   . PRO A 1 52  ? -23.01156 -31.09829 -5.87197  1.000 40.00547  ? 52  PRO A CB   1 
ATOM   763  C CG   . PRO A 1 52  ? -23.11074 -29.92998 -4.85111  1.000 39.91983  ? 52  PRO A CG   1 
ATOM   764  C CD   . PRO A 1 52  ? -23.29469 -28.67028 -5.67737  1.000 42.87054  ? 52  PRO A CD   1 
ATOM   765  H HA   . PRO A 1 52  ? -23.57682 -30.99822 -7.86024  1.000 44.83678  ? 52  PRO A HA   1 
ATOM   766  H HB2  . PRO A 1 52  ? -23.34655 -31.92673 -5.49465  1.000 48.06066  ? 52  PRO A HB2  1 
ATOM   767  H HB3  . PRO A 1 52  ? -22.10076 -31.21970 -6.18279  1.000 48.06066  ? 52  PRO A HB3  1 
ATOM   768  H HG2  . PRO A 1 52  ? -23.87136 -30.07085 -4.26587  1.000 47.95790  ? 52  PRO A HG2  1 
ATOM   769  H HG3  . PRO A 1 52  ? -22.29473 -29.88195 -4.32889  1.000 47.95790  ? 52  PRO A HG3  1 
ATOM   770  H HD2  . PRO A 1 52  ? -23.94965 -28.08342 -5.26806  1.000 51.49875  ? 52  PRO A HD2  1 
ATOM   771  H HD3  . PRO A 1 52  ? -22.45135 -28.20305 -5.78401  1.000 51.49875  ? 52  PRO A HD3  1 
ATOM   772  N N    . ASN A 1 53  ? -25.77451 -32.04697 -7.61516  1.000 29.57884  ? 53  ASN A N    1 
ATOM   773  C CA   . ASN A 1 53  ? -27.03241 -32.74985 -7.35644  1.000 38.14537  ? 53  ASN A CA   1 
ATOM   774  C C    . ASN A 1 53  ? -26.62701 -34.03814 -6.64722  1.000 36.14914  ? 53  ASN A C    1 
ATOM   775  O O    . ASN A 1 53  ? -26.27298 -35.01534 -7.30420  1.000 36.02018  ? 53  ASN A O    1 
ATOM   776  C CB   . ASN A 1 53  ? -27.77759 -33.03539 -8.65308  1.000 42.50081  ? 53  ASN A CB   1 
ATOM   777  C CG   . ASN A 1 53  ? -29.12495 -33.69200 -8.41130  1.000 40.05812  ? 53  ASN A CG   1 
ATOM   778  O OD1  . ASN A 1 53  ? -29.24638 -34.59870 -7.58829  1.000 48.09713  ? 53  ASN A OD1  1 
ATOM   779  N ND2  . ASN A 1 53  ? -30.14826 -33.22569 -9.12104  1.000 44.66419  ? 53  ASN A ND2  1 
ATOM   780  H H    . ASN A 1 53  ? -25.35011 -32.32613 -8.30911  1.000 35.54871  ? 53  ASN A H    1 
ATOM   781  H HA   . ASN A 1 53  ? -27.62109 -32.22063 -6.79584  1.000 45.82855  ? 53  ASN A HA   1 
ATOM   782  H HB2  . ASN A 1 53  ? -27.92878 -32.20049 -9.12317  1.000 51.05507  ? 53  ASN A HB2  1 
ATOM   783  H HB3  . ASN A 1 53  ? -27.24473 -33.63278 -9.20089  1.000 51.05507  ? 53  ASN A HB3  1 
ATOM   784  H HD21 . ASN A 1 53  ? -30.93194 -33.56508 -9.01977  1.000 53.65113  ? 53  ASN A HD21 1 
ATOM   785  H HD22 . ASN A 1 53  ? -30.02638 -32.58472 -9.68132  1.000 53.65113  ? 53  ASN A HD22 1 
ATOM   786  N N    . TYR A 1 54  ? -26.64782 -34.04356 -5.29701  1.000 33.16531  ? 54  TYR A N    1 
ATOM   787  C CA   . TYR A 1 54  ? -26.02061 -35.16134 -4.61120  1.000 35.19877  ? 54  TYR A CA   1 
ATOM   788  C C    . TYR A 1 54  ? -26.76008 -36.47465 -4.84039  1.000 40.41641  ? 54  TYR A C    1 
ATOM   789  O O    . TYR A 1 54  ? -26.12194 -37.52084 -4.91491  1.000 31.59973  ? 54  TYR A O    1 
ATOM   790  C CB   . TYR A 1 54  ? -25.91756 -34.90798 -3.12070  1.000 36.60338  ? 54  TYR A CB   1 
ATOM   791  C CG   . TYR A 1 54  ? -24.82330 -33.95271 -2.77630  1.000 33.75661  ? 54  TYR A CG   1 
ATOM   792  C CD1  . TYR A 1 54  ? -23.50484 -34.36985 -2.74815  1.000 31.52248  ? 54  TYR A CD1  1 
ATOM   793  C CD2  . TYR A 1 54  ? -25.10166 -32.62652 -2.49812  1.000 34.32805  ? 54  TYR A CD2  1 
ATOM   794  C CE1  . TYR A 1 54  ? -22.47938 -33.48177 -2.43890  1.000 28.52215  ? 54  TYR A CE1  1 
ATOM   795  C CE2  . TYR A 1 54  ? -24.08731 -31.73853 -2.15939  1.000 34.48088  ? 54  TYR A CE2  1 
ATOM   796  C CZ   . TYR A 1 54  ? -22.77846 -32.18935 -2.15743  1.000 24.55899  ? 54  TYR A CZ   1 
ATOM   797  O OH   . TYR A 1 54  ? -21.75772 -31.32003 -1.82596  1.000 31.30328  ? 54  TYR A OH   1 
ATOM   798  H H    . TYR A 1 54  ? -27.00121 -33.44127 -4.79504  1.000 39.85248  ? 54  TYR A H    1 
ATOM   799  H HA   . TYR A 1 54  ? -25.12288 -35.24135 -4.96978  1.000 42.29263  ? 54  TYR A HA   1 
ATOM   800  H HB2  . TYR A 1 54  ? -26.75472 -34.53352 -2.80474  1.000 43.97816  ? 54  TYR A HB2  1 
ATOM   801  H HB3  . TYR A 1 54  ? -25.73797 -35.74724 -2.66872  1.000 43.97816  ? 54  TYR A HB3  1 
ATOM   802  H HD1  . TYR A 1 54  ? -23.30077 -35.25695 -2.93873  1.000 37.88108  ? 54  TYR A HD1  1 
ATOM   803  H HD2  . TYR A 1 54  ? -25.98037 -32.32461 -2.53833  1.000 41.24777  ? 54  TYR A HD2  1 
ATOM   804  H HE1  . TYR A 1 54  ? -21.59598 -33.77215 -2.42533  1.000 34.28068  ? 54  TYR A HE1  1 
ATOM   805  H HE2  . TYR A 1 54  ? -24.28448 -30.85706 -1.93798  1.000 41.43115  ? 54  TYR A HE2  1 
ATOM   806  H HH   . TYR A 1 54  ? -22.05400 -30.53579 -1.77324  1.000 37.61804  ? 54  TYR A HH   1 
ATOM   807  N N    . GLU A 1 55  ? -28.08702 -36.43428 -4.98069  1.000 40.01330  ? 55  GLU A N    1 
ATOM   808  C CA   . GLU A 1 55  ? -28.83393 -37.65521 -5.25990  1.000 35.74142  ? 55  GLU A CA   1 
ATOM   809  C C    . GLU A 1 55  ? -28.36935 -38.29236 -6.56046  1.000 34.22403  ? 55  GLU A C    1 
ATOM   810  O O    . GLU A 1 55  ? -28.00021 -39.47831 -6.58665  1.000 38.86704  ? 55  GLU A O    1 
ATOM   811  C CB   . GLU A 1 55  ? -30.32964 -37.35442 -5.32549  1.000 43.32940  ? 55  GLU A CB   1 
ATOM   812  C CG   . GLU A 1 55  ? -30.97290 -37.06327 -3.99036  1.000 54.86641  ? 55  GLU A CG   1 
ATOM   813  C CD   . GLU A 1 55  ? -30.46496 -35.77870 -3.31420  1.000 68.12116  ? 55  GLU A CD   1 
ATOM   814  O OE1  . GLU A 1 55  ? -30.10541 -34.78525 -4.01478  1.000 55.21555  ? 55  GLU A OE1  1 
ATOM   815  O OE2  . GLU A 1 55  ? -30.43002 -35.76291 -2.05810  1.000 71.90803  ? 55  GLU A OE2  1 
ATOM   816  H H    . GLU A 1 55  ? -28.56815 -35.72408 -4.91956  1.000 48.07006  ? 55  GLU A H    1 
ATOM   817  H HA   . GLU A 1 55  ? -28.68117 -38.28332 -4.53668  1.000 42.94380  ? 55  GLU A HA   1 
ATOM   818  H HB2  . GLU A 1 55  ? -30.46332 -36.57707 -5.89008  1.000 52.04938  ? 55  GLU A HB2  1 
ATOM   819  H HB3  . GLU A 1 55  ? -30.78226 -38.12304 -5.70661  1.000 52.04938  ? 55  GLU A HB3  1 
ATOM   820  H HG2  . GLU A 1 55  ? -31.92948 -36.96863 -4.12033  1.000 65.89380  ? 55  GLU A HG2  1 
ATOM   821  H HG3  . GLU A 1 55  ? -30.79127 -37.80316 -3.38996  1.000 65.89380  ? 55  GLU A HG3  1 
ATOM   822  N N    . ASP A 1 56  ? -28.33530 -37.52018 -7.63772  1.000 37.39263  ? 56  ASP A N    1 
ATOM   823  C CA   . ASP A 1 56  ? -27.88000 -38.06891 -8.90797  1.000 40.52956  ? 56  ASP A CA   1 
ATOM   824  C C    . ASP A 1 56  ? -26.43386 -38.53702 -8.81464  1.000 42.72334  ? 56  ASP A C    1 
ATOM   825  O O    . ASP A 1 56  ? -26.08812 -39.59913 -9.33724  1.000 43.67891  ? 56  ASP A O    1 
ATOM   826  C CB   . ASP A 1 56  ? -28.03967 -37.03621 -10.02425 1.000 41.29678  ? 56  ASP A CB   1 
ATOM   827  C CG   . ASP A 1 56  ? -29.49291 -36.81696 -10.41807 1.000 48.84362  ? 56  ASP A CG   1 
ATOM   828  O OD1  . ASP A 1 56  ? -30.42638 -37.38662 -9.75822  1.000 44.20208  ? 56  ASP A OD1  1 
ATOM   829  O OD2  . ASP A 1 56  ? -29.68532 -36.07858 -11.40633 1.000 44.70470  ? 56  ASP A OD2  1 
ATOM   830  H H    . ASP A 1 56  ? -28.56540 -36.69187 -7.66134  1.000 44.92525  ? 56  ASP A H    1 
ATOM   831  H HA   . ASP A 1 56  ? -28.43360 -38.83326 -9.13202  1.000 48.68957  ? 56  ASP A HA   1 
ATOM   832  H HB2  . ASP A 1 56  ? -27.67875 -36.18743 -9.72390  1.000 49.61024  ? 56  ASP A HB2  1 
ATOM   833  H HB3  . ASP A 1 56  ? -27.55883 -37.34204 -10.80922 1.000 49.61024  ? 56  ASP A HB3  1 
ATOM   834  N N    . LEU A 1 57  ? -25.57149 -37.76221 -8.14860  1.000 39.52600  ? 57  LEU A N    1 
ATOM   835  C CA   . LEU A 1 57  ? -24.16679 -38.14078 -8.08932  1.000 35.91784  ? 57  LEU A CA   1 
ATOM   836  C C    . LEU A 1 57  ? -23.99257 -39.44780 -7.33849  1.000 38.01205  ? 57  LEU A C    1 
ATOM   837  O O    . LEU A 1 57  ? -23.20081 -40.31111 -7.74252  1.000 37.63890  ? 57  LEU A O    1 
ATOM   838  C CB   . LEU A 1 57  ? -23.33232 -37.03421 -7.43540  1.000 33.97032  ? 57  LEU A CB   1 
ATOM   839  C CG   . LEU A 1 57  ? -23.12195 -35.80337 -8.30389  1.000 38.78803  ? 57  LEU A CG   1 
ATOM   840  C CD1  . LEU A 1 57  ? -22.51164 -34.71374 -7.41731  1.000 40.03570  ? 57  LEU A CD1  1 
ATOM   841  C CD2  . LEU A 1 57  ? -22.22727 -36.17390 -9.46693  1.000 44.80472  ? 57  LEU A CD2  1 
ATOM   842  H H    . LEU A 1 57  ? -25.77243 -37.03479 -7.73619  1.000 47.48530  ? 57  LEU A H    1 
ATOM   843  H HA   . LEU A 1 57  ? -23.83991 -38.25604 -8.99528  1.000 43.15551  ? 57  LEU A HA   1 
ATOM   844  H HB2  . LEU A 1 57  ? -23.78166 -36.74789 -6.62484  1.000 40.81848  ? 57  LEU A HB2  1 
ATOM   845  H HB3  . LEU A 1 57  ? -22.45771 -37.39437 -7.22035  1.000 40.81848  ? 57  LEU A HB3  1 
ATOM   846  H HG   . LEU A 1 57  ? -23.94830 -35.46225 -8.68032  1.000 46.59974  ? 57  LEU A HG   1 
ATOM   847  H HD11 . LEU A 1 57  ? -22.20202 -33.98614 -7.97913  1.000 48.09695  ? 57  LEU A HD11 1 
ATOM   848  H HD12 . LEU A 1 57  ? -23.18858 -34.39143 -6.80187  1.000 48.09695  ? 57  LEU A HD12 1 
ATOM   849  H HD13 . LEU A 1 57  ? -21.76679 -35.08962 -6.92252  1.000 48.09695  ? 57  LEU A HD13 1 
ATOM   850  H HD21 . LEU A 1 57  ? -21.87504 -35.36267 -9.86536  1.000 53.81976  ? 57  LEU A HD21 1 
ATOM   851  H HD22 . LEU A 1 57  ? -21.49897 -36.72593 -9.14175  1.000 53.81976  ? 57  LEU A HD22 1 
ATOM   852  H HD23 . LEU A 1 57  ? -22.74772 -36.66505 -10.12176 1.000 53.81976  ? 57  LEU A HD23 1 
ATOM   853  N N    . LEU A 1 58  ? -24.74860 -39.62338 -6.25584  1.000 36.74999  ? 58  LEU A N    1 
ATOM   854  C CA   . LEU A 1 58  ? -24.59910 -40.80002 -5.42301  1.000 33.29456  ? 58  LEU A CA   1 
ATOM   855  C C    . LEU A 1 58  ? -25.00963 -42.05355 -6.17511  1.000 35.46596  ? 58  LEU A C    1 
ATOM   856  O O    . LEU A 1 58  ? -24.41866 -43.11837 -5.98322  1.000 36.42519  ? 58  LEU A O    1 
ATOM   857  C CB   . LEU A 1 58  ? -25.43480 -40.65042 -4.14569  1.000 34.72613  ? 58  LEU A CB   1 
ATOM   858  C CG   . LEU A 1 58  ? -25.21521 -41.69246 -3.07151  1.000 33.68412  ? 58  LEU A CG   1 
ATOM   859  C CD1  . LEU A 1 58  ? -23.72384 -41.84938 -2.80096  1.000 37.61322  ? 58  LEU A CD1  1 
ATOM   860  C CD2  . LEU A 1 58  ? -25.97085 -41.33087 -1.78937  1.000 34.59767  ? 58  LEU A CD2  1 
ATOM   861  H H    . LEU A 1 58  ? -25.35300 -39.07417 -5.98629  1.000 44.15409  ? 58  LEU A H    1 
ATOM   862  H HA   . LEU A 1 58  ? -23.66934 -40.88872 -5.16113  1.000 40.00758  ? 58  LEU A HA   1 
ATOM   863  H HB2  . LEU A 1 58  ? -25.23076 -39.78761 -3.75219  1.000 41.72546  ? 58  LEU A HB2  1 
ATOM   864  H HB3  . LEU A 1 58  ? -26.37190 -40.68889 -4.39323  1.000 41.72546  ? 58  LEU A HB3  1 
ATOM   865  H HG   . LEU A 1 58  ? -25.56335 -42.54469 -3.37713  1.000 40.47504  ? 58  LEU A HG   1 
ATOM   866  H HD11 . LEU A 1 58  ? -23.60252 -42.27365 -1.93715  1.000 45.18996  ? 58  LEU A HD11 1 
ATOM   867  H HD12 . LEU A 1 58  ? -23.33269 -42.39953 -3.49755  1.000 45.18996  ? 58  LEU A HD12 1 
ATOM   868  H HD13 . LEU A 1 58  ? -23.30909 -40.97253 -2.79999  1.000 45.18996  ? 58  LEU A HD13 1 
ATOM   869  H HD21 . LEU A 1 58  ? -26.89213 -41.12560 -2.01299  1.000 41.57130  ? 58  LEU A HD21 1 
ATOM   870  H HD22 . LEU A 1 58  ? -25.93846 -42.08513 -1.18033  1.000 41.57130  ? 58  LEU A HD22 1 
ATOM   871  H HD23 . LEU A 1 58  ? -25.54938 -40.55818 -1.38166  1.000 41.57130  ? 58  LEU A HD23 1 
ATOM   872  N N    . ILE A 1 59  ? -25.99450 -41.92512 -7.04875  1.000 40.51480  ? 59  ILE A N    1 
ATOM   873  C CA   . ILE A 1 59  ? -26.58563 -43.08144 -7.70662  1.000 36.22970  ? 59  ILE A CA   1 
ATOM   874  C C    . ILE A 1 59  ? -25.59082 -43.76831 -8.61979  1.000 41.94681  ? 59  ILE A C    1 
ATOM   875  O O    . ILE A 1 59  ? -25.68771 -44.97438 -8.85469  1.000 45.94801  ? 59  ILE A O    1 
ATOM   876  C CB   . ILE A 1 59  ? -27.84132 -42.61381 -8.46314  1.000 43.09781  ? 59  ILE A CB   1 
ATOM   877  C CG1  . ILE A 1 59  ? -28.99584 -42.54456 -7.46048  1.000 47.46983  ? 59  ILE A CG1  1 
ATOM   878  C CG2  . ILE A 1 59  ? -28.07958 -43.48372 -9.66995  1.000 53.24850  ? 59  ILE A CG2  1 
ATOM   879  C CD1  . ILE A 1 59  ? -30.22786 -41.93487 -7.99899  1.000 57.19890  ? 59  ILE A CD1  1 
ATOM   880  H H    . ILE A 1 59  ? -26.34370 -41.17468 -7.28221  1.000 48.67186  ? 59  ILE A H    1 
ATOM   881  H HA   . ILE A 1 59  ? -26.84023 -43.73980 -7.04130  1.000 43.52975  ? 59  ILE A HA   1 
ATOM   882  H HB   . ILE A 1 59  ? -27.73621 -41.72189 -8.82963  1.000 51.77147  ? 59  ILE A HB   1 
ATOM   883  H HG12 . ILE A 1 59  ? -29.21371 -43.44573 -7.17532  1.000 57.01789  ? 59  ILE A HG12 1 
ATOM   884  H HG13 . ILE A 1 59  ? -28.71384 -42.01455 -6.69859  1.000 57.01789  ? 59  ILE A HG13 1 
ATOM   885  H HG21 . ILE A 1 59  ? -28.96466 -43.30010 -10.02183 1.000 63.95230  ? 59  ILE A HG21 1 
ATOM   886  H HG22 . ILE A 1 59  ? -27.40862 -43.28326 -10.34117 1.000 63.95230  ? 59  ILE A HG22 1 
ATOM   887  H HG23 . ILE A 1 59  ? -28.01528 -44.41483 -9.40574  1.000 63.95230  ? 59  ILE A HG23 1 
ATOM   888  H HD11 . ILE A 1 59  ? -30.90174 -41.91587 -7.30155  1.000 68.69278  ? 59  ILE A HD11 1 
ATOM   889  H HD12 . ILE A 1 59  ? -30.03079 -41.03182 -8.29322  1.000 68.69278  ? 59  ILE A HD12 1 
ATOM   890  H HD13 . ILE A 1 59  ? -30.54166 -42.46566 -8.74779  1.000 68.69278  ? 59  ILE A HD13 1 
ATOM   891  N N    . ARG A 1 60  ? -24.64091 -43.02572 -9.16666  1.000 39.19945  ? 60  ARG A N    1 
ATOM   892  C CA   . ARG A 1 60  ? -23.58829 -43.64061 -9.96384  1.000 43.42078  ? 60  ARG A CA   1 
ATOM   893  C C    . ARG A 1 60  ? -22.53803 -44.33790 -9.10716  1.000 41.09860  ? 60  ARG A C    1 
ATOM   894  O O    . ARG A 1 60  ? -21.62608 -44.96848 -9.65813  1.000 41.27636  ? 60  ARG A O    1 
ATOM   895  C CB   . ARG A 1 60  ? -22.98803 -42.56158 -10.87467 1.000 50.45321  ? 60  ARG A CB   1 
ATOM   896  C CG   . ARG A 1 60  ? -24.02110 -42.04911 -11.91215 1.000 60.02002  ? 60  ARG A CG   1 
ATOM   897  C CD   . ARG A 1 60  ? -23.35779 -41.47619 -13.15117 1.000 86.14490  ? 60  ARG A CD   1 
ATOM   898  N NE   . ARG A 1 60  ? -22.47063 -40.37250 -12.80673 1.000 94.76079  ? 60  ARG A NE   1 
ATOM   899  C CZ   . ARG A 1 60  ? -22.88131 -39.14109 -12.53845 1.000 79.21623  ? 60  ARG A CZ   1 
ATOM   900  N NH1  . ARG A 1 60  ? -24.16692 -38.82078 -12.56154 1.000 77.84037  ? 60  ARG A NH1  1 
ATOM   901  N NH2  . ARG A 1 60  ? -21.97994 -38.20779 -12.24173 1.000 77.19846  ? 60  ARG A NH2  1 
ATOM   902  H H    . ARG A 1 60  ? -24.58318 -42.17090 -9.09222  1.000 47.09345  ? 60  ARG A H    1 
ATOM   903  H HA   . ARG A 1 60  ? -23.94489 -44.33266 -10.54245 1.000 52.15903  ? 60  ARG A HA   1 
ATOM   904  H HB2  . ARG A 1 60  ? -22.70051 -41.80971 -10.33344 1.000 60.59795  ? 60  ARG A HB2  1 
ATOM   905  H HB3  . ARG A 1 60  ? -22.23165 -42.93297 -11.35514 1.000 60.59795  ? 60  ARG A HB3  1 
ATOM   906  H HG2  . ARG A 1 60  ? -24.58816 -42.78638 -12.18744 1.000 72.07813  ? 60  ARG A HG2  1 
ATOM   907  H HG3  . ARG A 1 60  ? -24.55857 -41.35031 -11.50755 1.000 72.07813  ? 60  ARG A HG3  1 
ATOM   908  H HD2  . ARG A 1 60  ? -22.83375 -42.16722 -13.58563 1.000 103.42798 ? 60  ARG A HD2  1 
ATOM   909  H HD3  . ARG A 1 60  ? -24.03837 -41.14516 -13.75791 1.000 103.42798 ? 60  ARG A HD3  1 
ATOM   910  H HE   . ARG A 1 60  ? -21.62582 -40.53039 -12.77551 1.000 113.76704 ? 60  ARG A HE   1 
ATOM   911  H HH11 . ARG A 1 60  ? -24.75541 -39.41775 -12.75365 1.000 93.46254  ? 60  ARG A HH11 1 
ATOM   912  H HH12 . ARG A 1 60  ? -24.41279 -38.01594 -12.38442 1.000 93.46254  ? 60  ARG A HH12 1 
ATOM   913  H HH21 . ARG A 1 60  ? -21.14356 -38.40736 -12.22592 1.000 92.69225  ? 60  ARG A HH21 1 
ATOM   914  H HH22 . ARG A 1 60  ? -22.23391 -37.40520 -12.06581 1.000 92.69225  ? 60  ARG A HH22 1 
ATOM   915  N N    . LYS A 1 61  ? -22.68375 -44.33976 -7.78562  1.000 41.50277  ? 61  LYS A N    1 
ATOM   916  C CA   . LYS A 1 61  ? -21.68387 -44.90458 -6.88968  1.000 40.86251  ? 61  LYS A CA   1 
ATOM   917  C C    . LYS A 1 61  ? -22.17702 -46.21246 -6.28545  1.000 38.74900  ? 61  LYS A C    1 
ATOM   918  O O    . LYS A 1 61  ? -23.34430 -46.33253 -5.89411  1.000 41.87284  ? 61  LYS A O    1 
ATOM   919  C CB   . LYS A 1 61  ? -21.33685 -43.92631 -5.75921  1.000 38.96319  ? 61  LYS A CB   1 
ATOM   920  C CG   . LYS A 1 61  ? -20.75344 -42.60129 -6.25426  1.000 39.39841  ? 61  LYS A CG   1 
ATOM   921  C CD   . LYS A 1 61  ? -19.44663 -42.76673 -7.00834  1.000 41.72650  ? 61  LYS A CD   1 
ATOM   922  C CE   . LYS A 1 61  ? -19.00024 -41.39545 -7.46747  1.000 43.33754  ? 61  LYS A CE   1 
ATOM   923  N NZ   . LYS A 1 61  ? -17.69124 -41.40565 -8.18495  1.000 51.89924  ? 61  LYS A NZ   1 
ATOM   924  H H    . LYS A 1 61  ? -23.36702 -44.01290 -7.37830  1.000 49.85742  ? 61  LYS A H    1 
ATOM   925  H HA   . LYS A 1 61  ? -20.88154 -45.09118 -7.40189  1.000 49.08912  ? 61  LYS A HA   1 
ATOM   926  H HB2  . LYS A 1 61  ? -22.14404 -43.72711 -5.25954  1.000 46.80993  ? 61  LYS A HB2  1 
ATOM   927  H HB3  . LYS A 1 61  ? -20.68049 -44.34091 -5.17765  1.000 46.80993  ? 61  LYS A HB3  1 
ATOM   928  H HG2  . LYS A 1 61  ? -21.39085 -42.18081 -6.85242  1.000 47.33220  ? 61  LYS A HG2  1 
ATOM   929  H HG3  . LYS A 1 61  ? -20.58574 -42.02664 -5.49101  1.000 47.33220  ? 61  LYS A HG3  1 
ATOM   930  H HD2  . LYS A 1 61  ? -18.76944 -43.14571 -6.42638  1.000 50.12590  ? 61  LYS A HD2  1 
ATOM   931  H HD3  . LYS A 1 61  ? -19.57602 -43.33710 -7.78218  1.000 50.12590  ? 61  LYS A HD3  1 
ATOM   932  H HE2  . LYS A 1 61  ? -19.66729 -41.03474 -8.07232  1.000 52.05914  ? 61  LYS A HE2  1 
ATOM   933  H HE3  . LYS A 1 61  ? -18.90922 -40.81947 -6.69232  1.000 52.05914  ? 61  LYS A HE3  1 
ATOM   934  H HZ1  . LYS A 1 61  ? -17.48778 -40.58362 -8.45876  1.000 62.33319  ? 61  LYS A HZ1  1 
ATOM   935  H HZ2  . LYS A 1 61  ? -17.04880 -41.69653 -7.64203  1.000 62.33319  ? 61  LYS A HZ2  1 
ATOM   936  H HZ3  . LYS A 1 61  ? -17.73636 -41.94304 -8.89296  1.000 62.33319  ? 61  LYS A HZ3  1 
ATOM   937  N N    . SER A 1 62  ? -21.27609 -47.18238 -6.19056  1.000 35.86606  ? 62  SER A N    1 
ATOM   938  C CA   . SER A 1 62  ? -21.53662 -48.45446 -5.54807  1.000 34.42075  ? 62  SER A CA   1 
ATOM   939  C C    . SER A 1 62  ? -20.56891 -48.59786 -4.37589  1.000 38.04471  ? 62  SER A C    1 
ATOM   940  O O    . SER A 1 62  ? -19.60683 -47.83344 -4.25192  1.000 40.23008  ? 62  SER A O    1 
ATOM   941  C CB   . SER A 1 62  ? -21.39717 -49.62698 -6.53270  1.000 37.61690  ? 62  SER A CB   1 
ATOM   942  O OG   . SER A 1 62  ? -22.03159 -49.34917 -7.76914  1.000 47.72911  ? 62  SER A OG   1 
ATOM   943  H H    . SER A 1 62  ? -20.47769 -47.12039 -6.50412  1.000 43.09337  ? 62  SER A H    1 
ATOM   944  H HA   . SER A 1 62  ? -22.44629 -48.48305 -5.21253  1.000 41.35900  ? 62  SER A HA   1 
ATOM   945  H HB2  . SER A 1 62  ? -20.45456 -49.78894 -6.69445  1.000 45.19439  ? 62  SER A HB2  1 
ATOM   946  H HB3  . SER A 1 62  ? -21.80667 -50.41434 -6.14120  1.000 45.19439  ? 62  SER A HB3  1 
ATOM   947  H HG   . SER A 1 62  ? -21.45686 -49.15099 -8.34881  1.000 57.32904  ? 62  SER A HG   1 
ATOM   948  N N    . ASN A 1 63  ? -20.82670 -49.60474 -3.52213  1.000 37.75961  ? 63  ASN A N    1 
ATOM   949  C CA   . ASN A 1 63  ? -19.99127 -49.82736 -2.34256  1.000 33.15403  ? 63  ASN A CA   1 
ATOM   950  C C    . ASN A 1 63  ? -18.49542 -49.87205 -2.68434  1.000 38.37546  ? 63  ASN A C    1 
ATOM   951  O O    . ASN A 1 63  ? -17.67277 -49.31016 -1.95979  1.000 34.07554  ? 63  ASN A O    1 
ATOM   952  C CB   . ASN A 1 63  ? -20.37701 -51.12293 -1.64418  1.000 36.34427  ? 63  ASN A CB   1 
ATOM   953  C CG   . ASN A 1 63  ? -21.80075 -51.09563 -1.06898  1.000 40.87441  ? 63  ASN A CG   1 
ATOM   954  O OD1  . ASN A 1 63  ? -22.27782 -50.06064 -0.62114  1.000 33.55699  ? 63  ASN A OD1  1 
ATOM   955  N ND2  . ASN A 1 63  ? -22.46819 -52.24300 -1.08256  1.000 40.32874  ? 63  ASN A ND2  1 
ATOM   956  H H    . ASN A 1 63  ? -21.47399 -50.16459 -3.60694  1.000 45.36563  ? 63  ASN A H    1 
ATOM   957  H HA   . ASN A 1 63  ? -20.14900 -49.08413 -1.73954  1.000 39.83893  ? 63  ASN A HA   1 
ATOM   958  H HB2  . ASN A 1 63  ? -20.32667 -51.85173 -2.28231  1.000 43.66722  ? 63  ASN A HB2  1 
ATOM   959  H HB3  . ASN A 1 63  ? -19.76174 -51.28077 -0.91108  1.000 43.66722  ? 63  ASN A HB3  1 
ATOM   960  H HD21 . ASN A 1 63  ? -23.26913 -52.27825 -0.77133  1.000 48.44859  ? 63  ASN A HD21 1 
ATOM   961  H HD22 . ASN A 1 63  ? -22.09967 -52.95108 -1.40258  1.000 48.44859  ? 63  ASN A HD22 1 
ATOM   962  N N    . HIS A 1 64  ? -18.11972 -50.57650 -3.74924  1.000 37.95616  ? 64  HIS A N    1 
ATOM   963  C CA   . HIS A 1 64  ? -16.69309 -50.74022 -4.04252  1.000 40.08472  ? 64  HIS A CA   1 
ATOM   964  C C    . HIS A 1 64  ? -16.03401 -49.45959 -4.53780  1.000 39.96456  ? 64  HIS A C    1 
ATOM   965  O O    . HIS A 1 64  ? -14.79568 -49.43171 -4.66406  1.000 35.31707  ? 64  HIS A O    1 
ATOM   966  C CB   . HIS A 1 64  ? -16.48145 -51.87187 -5.06919  1.000 43.08730  ? 64  HIS A CB   1 
ATOM   967  C CG   . HIS A 1 64  ? -17.03065 -51.58309 -6.43214  1.000 41.61080  ? 64  HIS A CG   1 
ATOM   968  N ND1  . HIS A 1 64  ? -18.22513 -52.10769 -6.87379  1.000 45.57634  ? 64  HIS A ND1  1 
ATOM   969  C CD2  . HIS A 1 64  ? -16.53330 -50.85714 -7.46279  1.000 42.71287  ? 64  HIS A CD2  1 
ATOM   970  C CE1  . HIS A 1 64  ? -18.44689 -51.70315 -8.11398  1.000 52.60034  ? 64  HIS A CE1  1 
ATOM   971  N NE2  . HIS A 1 64  ? -17.43014 -50.95241 -8.49871  1.000 40.30666  ? 64  HIS A NE2  1 
ATOM   972  H H    . HIS A 1 64  ? -18.65397 -50.95986 -4.30351  1.000 45.60149  ? 64  HIS A H    1 
ATOM   973  H HA   . HIS A 1 64  ? -16.24441 -51.00072 -3.22293  1.000 48.15576  ? 64  HIS A HA   1 
ATOM   974  H HB2  . HIS A 1 64  ? -15.52898 -52.02894 -5.16425  1.000 51.75886  ? 64  HIS A HB2  1 
ATOM   975  H HB3  . HIS A 1 64  ? -16.91866 -52.67305 -4.74076  1.000 51.75886  ? 64  HIS A HB3  1 
ATOM   976  H HD2  . HIS A 1 64  ? -15.73346 -50.38268 -7.46772  1.000 51.30955  ? 64  HIS A HD2  1 
ATOM   977  H HE1  . HIS A 1 64  ? -19.19300 -51.91216 -8.62831  1.000 63.17451  ? 64  HIS A HE1  1 
ATOM   978  H HE2  . HIS A 1 64  ? -17.34397 -50.58387 -9.27095  1.000 48.42209  ? 64  HIS A HE2  1 
ATOM   979  N N    . ASN A 1 65  ? -16.80999 -48.40995 -4.82269  1.000 37.44020  ? 65  ASN A N    1 
ATOM   980  C CA   . ASN A 1 65  ? -16.24948 -47.11719 -5.16283  1.000 34.34638  ? 65  ASN A CA   1 
ATOM   981  C C    . ASN A 1 65  ? -15.83317 -46.32459 -3.92780  1.000 39.49986  ? 65  ASN A C    1 
ATOM   982  O O    . ASN A 1 65  ? -15.16728 -45.31107 -4.06019  1.000 34.89955  ? 65  ASN A O    1 
ATOM   983  C CB   . ASN A 1 65  ? -17.23799 -46.25996 -5.95375  1.000 33.28512  ? 65  ASN A CB   1 
ATOM   984  C CG   . ASN A 1 65  ? -17.62188 -46.86950 -7.29554  1.000 44.53669  ? 65  ASN A CG   1 
ATOM   985  O OD1  . ASN A 1 65  ? -18.80740 -47.01467 -7.59946  1.000 42.34584  ? 65  ASN A OD1  1 
ATOM   986  N ND2  . ASN A 1 65  ? -16.62400 -47.20975 -8.10980  1.000 39.75015  ? 65  ASN A ND2  1 
ATOM   987  H H    . ASN A 1 65  ? -17.66978 -48.42904 -4.82369  1.000 44.98234  ? 65  ASN A H    1 
ATOM   988  H HA   . ASN A 1 65  ? -15.47934 -47.27860 -5.73005  1.000 41.26976  ? 65  ASN A HA   1 
ATOM   989  H HB2  . ASN A 1 65  ? -18.04879 -46.15312 -5.43214  1.000 39.99625  ? 65  ASN A HB2  1 
ATOM   990  H HB3  . ASN A 1 65  ? -16.83648 -45.39354 -6.12405  1.000 39.99625  ? 65  ASN A HB3  1 
ATOM   991  H HD21 . ASN A 1 65  ? -16.79502 -47.55737 -8.87760  1.000 47.75428  ? 65  ASN A HD21 1 
ATOM   992  H HD22 . ASN A 1 65  ? -15.80877 -47.08180 -7.86768  1.000 47.75428  ? 65  ASN A HD22 1 
ATOM   993  N N    . PHE A 1 66  ? -16.20480 -46.74832 -2.73661  1.000 36.38340  ? 66  PHE A N    1 
ATOM   994  C CA   . PHE A 1 66  ? -15.75693 -46.06882 -1.52521  1.000 38.30887  ? 66  PHE A CA   1 
ATOM   995  C C    . PHE A 1 66  ? -14.59406 -46.84694 -0.92773  1.000 36.70707  ? 66  PHE A C    1 
ATOM   996  O O    . PHE A 1 66  ? -14.78515 -47.93644 -0.37256  1.000 38.22132  ? 66  PHE A O    1 
ATOM   997  C CB   . PHE A 1 66  ? -16.92023 -45.93343 -0.55353  1.000 37.80733  ? 66  PHE A CB   1 
ATOM   998  C CG   . PHE A 1 66  ? -18.00590 -45.06357 -1.06740  1.000 42.85612  ? 66  PHE A CG   1 
ATOM   999  C CD1  . PHE A 1 66  ? -17.86308 -43.67696 -1.04267  1.000 37.20796  ? 66  PHE A CD1  1 
ATOM   1000 C CD2  . PHE A 1 66  ? -19.17751 -45.61183 -1.55650  1.000 39.72324  ? 66  PHE A CD2  1 
ATOM   1001 C CE1  . PHE A 1 66  ? -18.85860 -42.86735 -1.51873  1.000 36.75200  ? 66  PHE A CE1  1 
ATOM   1002 C CE2  . PHE A 1 66  ? -20.18944 -44.79901 -2.02817  1.000 42.43230  ? 66  PHE A CE2  1 
ATOM   1003 C CZ   . PHE A 1 66  ? -20.02622 -43.41515 -1.99963  1.000 41.73258  ? 66  PHE A CZ   1 
ATOM   1004 H H    . PHE A 1 66  ? -16.71556 -47.42629 -2.59843  1.000 43.71418  ? 66  PHE A H    1 
ATOM   1005 H HA   . PHE A 1 66  ? -15.42796 -45.18124 -1.73707  1.000 46.02474  ? 66  PHE A HA   1 
ATOM   1006 H HB2  . PHE A 1 66  ? -17.29477 -46.81245 -0.38636  1.000 45.42290  ? 66  PHE A HB2  1 
ATOM   1007 H HB3  . PHE A 1 66  ? -16.59504 -45.54829 0.27521   1.000 45.42290  ? 66  PHE A HB3  1 
ATOM   1008 H HD1  . PHE A 1 66  ? -17.08537 -43.29924 -0.70006  1.000 44.70366  ? 66  PHE A HD1  1 
ATOM   1009 H HD2  . PHE A 1 66  ? -19.28483 -46.53554 -1.56787  1.000 47.72199  ? 66  PHE A HD2  1 
ATOM   1010 H HE1  . PHE A 1 66  ? -18.74583 -41.94421 -1.51730  1.000 44.15650  ? 66  PHE A HE1  1 
ATOM   1011 H HE2  . PHE A 1 66  ? -20.97325 -45.17192 -2.36206  1.000 50.97286  ? 66  PHE A HE2  1 
ATOM   1012 H HZ   . PHE A 1 66  ? -20.70732 -42.86095 -2.30600  1.000 50.13320  ? 66  PHE A HZ   1 
ATOM   1013 N N    . LEU A 1 67  ? -13.40376 -46.26714 -1.02972  1.000 34.30441  ? 67  LEU A N    1 
ATOM   1014 C CA   . LEU A 1 67  ? -12.18666 -46.82003 -0.46414  1.000 38.45974  ? 67  LEU A CA   1 
ATOM   1015 C C    . LEU A 1 67  ? -11.97125 -46.25940 0.93816   1.000 37.17557  ? 67  LEU A C    1 
ATOM   1016 O O    . LEU A 1 67  ? -11.69347 -45.06617 1.09051   1.000 31.57113  ? 67  LEU A O    1 
ATOM   1017 C CB   . LEU A 1 67  ? -10.98616 -46.46549 -1.33825  1.000 38.42910  ? 67  LEU A CB   1 
ATOM   1018 C CG   . LEU A 1 67  ? -10.99730 -46.97451 -2.77769  1.000 53.13051  ? 67  LEU A CG   1 
ATOM   1019 C CD1  . LEU A 1 67  ? -9.82643  -46.38176 -3.57469  1.000 50.10102  ? 67  LEU A CD1  1 
ATOM   1020 C CD2  . LEU A 1 67  ? -10.93658 -48.48819 -2.76194  1.000 55.82233  ? 67  LEU A CD2  1 
ATOM   1021 H H    . LEU A 1 67  ? -13.27301 -45.52226 -1.43919  1.000 41.21939  ? 67  LEU A H    1 
ATOM   1022 H HA   . LEU A 1 67  ? -12.27549 -47.78441 -0.40949  1.000 46.20578  ? 67  LEU A HA   1 
ATOM   1023 H HB2  . LEU A 1 67  ? -10.92450 -45.49841 -1.38145  1.000 46.16902  ? 67  LEU A HB2  1 
ATOM   1024 H HB3  . LEU A 1 67  ? -10.19249 -46.83000 -0.91622  1.000 46.16902  ? 67  LEU A HB3  1 
ATOM   1025 H HG   . LEU A 1 67  ? -11.81234 -46.69649 -3.22413  1.000 63.81072  ? 67  LEU A HG   1 
ATOM   1026 H HD11 . LEU A 1 67  ? -9.98228  -45.43352 -3.70680  1.000 60.17532  ? 67  LEU A HD11 1 
ATOM   1027 H HD12 . LEU A 1 67  ? -9.00518  -46.51569 -3.07618  1.000 60.17532  ? 67  LEU A HD12 1 
ATOM   1028 H HD13 . LEU A 1 67  ? -9.76936  -46.83031 -4.43285  1.000 60.17532  ? 67  LEU A HD13 1 
ATOM   1029 H HD21 . LEU A 1 67  ? -11.65666 -48.82738 -2.20756  1.000 67.04090  ? 67  LEU A HD21 1 
ATOM   1030 H HD22 . LEU A 1 67  ? -11.03420 -48.81762 -3.66905  1.000 67.04090  ? 67  LEU A HD22 1 
ATOM   1031 H HD23 . LEU A 1 67  ? -10.08092 -48.76617 -2.39936  1.000 67.04090  ? 67  LEU A HD23 1 
ATOM   1032 N N    . VAL A 1 68  ? -12.01838 -47.13846 1.92556   1.000 30.81877  ? 68  VAL A N    1 
ATOM   1033 C CA   . VAL A 1 68  ? -11.88871 -46.78218 3.33812   1.000 32.16390  ? 68  VAL A CA   1 
ATOM   1034 C C    . VAL A 1 68  ? -10.65699 -47.47542 3.89127   1.000 35.28830  ? 68  VAL A C    1 
ATOM   1035 O O    . VAL A 1 68  ? -10.58672 -48.71978 3.89356   1.000 39.89006  ? 68  VAL A O    1 
ATOM   1036 C CB   . VAL A 1 68  ? -13.15120 -47.18395 4.11944   1.000 36.47630  ? 68  VAL A CB   1 
ATOM   1037 C CG1  . VAL A 1 68  ? -13.06902 -46.77207 5.61523   1.000 37.34345  ? 68  VAL A CG1  1 
ATOM   1038 C CG2  . VAL A 1 68  ? -14.36946 -46.58574 3.42820   1.000 38.99307  ? 68  VAL A CG2  1 
ATOM   1039 H H    . VAL A 1 68  ? -12.12897 -47.98235 1.80218   1.000 37.03662  ? 68  VAL A H    1 
ATOM   1040 H HA   . VAL A 1 68  ? -11.75241 -45.82598 3.42756   1.000 38.65078  ? 68  VAL A HA   1 
ATOM   1041 H HB   . VAL A 1 68  ? -13.23458 -48.15035 4.12209   1.000 43.82566  ? 68  VAL A HB   1 
ATOM   1042 H HG11 . VAL A 1 68  ? -12.87343 -45.82365 5.67134   1.000 44.86624  ? 68  VAL A HG11 1 
ATOM   1043 H HG12 . VAL A 1 68  ? -13.91966 -46.96018 6.04177   1.000 44.86624  ? 68  VAL A HG12 1 
ATOM   1044 H HG13 . VAL A 1 68  ? -12.36388 -47.28121 6.04470   1.000 44.86624  ? 68  VAL A HG13 1 
ATOM   1045 H HG21 . VAL A 1 68  ? -14.07564 -45.90114 2.80700   1.000 46.84579  ? 68  VAL A HG21 1 
ATOM   1046 H HG22 . VAL A 1 68  ? -14.83748 -47.28777 2.94966   1.000 46.84579  ? 68  VAL A HG22 1 
ATOM   1047 H HG23 . VAL A 1 68  ? -14.95304 -46.19620 4.09798   1.000 46.84579  ? 68  VAL A HG23 1 
ATOM   1048 N N    . GLN A 1 69  ? -9.69007  -46.68114 4.37059   1.000 35.68249  ? 69  GLN A N    1 
ATOM   1049 C CA   . GLN A 1 69  ? -8.43705  -47.17447 4.91901   1.000 44.85601  ? 69  GLN A CA   1 
ATOM   1050 C C    . GLN A 1 69  ? -8.27958  -46.74594 6.37362   1.000 46.28310  ? 69  GLN A C    1 
ATOM   1051 O O    . GLN A 1 69  ? -8.36783  -45.55763 6.68009   1.000 38.13791  ? 69  GLN A O    1 
ATOM   1052 C CB   . GLN A 1 69  ? -7.25729  -46.63657 4.09107   1.000 47.41639  ? 69  GLN A CB   1 
ATOM   1053 C CG   . GLN A 1 69  ? -6.10398  -47.59140 4.00029   1.000 53.46004  ? 69  GLN A CG   1 
ATOM   1054 C CD   . GLN A 1 69  ? -5.09925  -47.22018 2.92474   1.000 52.20304  ? 69  GLN A CD   1 
ATOM   1055 O OE1  . GLN A 1 69  ? -5.39110  -46.45308 2.00912   1.000 50.46429  ? 69  GLN A OE1  1 
ATOM   1056 N NE2  . GLN A 1 69  ? -3.90847  -47.79599 3.02152   1.000 66.29960  ? 69  GLN A NE2  1 
ATOM   1057 H H    . GLN A 1 69  ? -9.74701  -45.82315 4.38557   1.000 42.87308  ? 69  GLN A H    1 
ATOM   1058 H HA   . GLN A 1 69  ? -8.44136  -48.14431 4.90189   1.000 53.88131  ? 69  GLN A HA   1 
ATOM   1059 H HB2  . GLN A 1 69  ? -7.56504  -46.45595 3.18909   1.000 56.95377  ? 69  GLN A HB2  1 
ATOM   1060 H HB3  . GLN A 1 69  ? -6.93446  -45.81907 4.50140   1.000 56.95377  ? 69  GLN A HB3  1 
ATOM   1061 H HG2  . GLN A 1 69  ? -5.63833  -47.60293 4.85113   1.000 64.20616  ? 69  GLN A HG2  1 
ATOM   1062 H HG3  . GLN A 1 69  ? -6.44456  -48.47648 3.79648   1.000 64.20616  ? 69  GLN A HG3  1 
ATOM   1063 H HE21 . GLN A 1 69  ? -3.74594  -48.34197 3.66579   1.000 79.61362  ? 69  GLN A HE21 1 
ATOM   1064 H HE22 . GLN A 1 69  ? -3.29884  -47.62339 2.44000   1.000 79.61362  ? 69  GLN A HE22 1 
ATOM   1065 N N    . ALA A 1 70  ? -8.04823  -47.71000 7.26763   1.000 41.77248  ? 70  ALA A N    1 
ATOM   1066 C CA   . ALA A 1 70  ? -7.70572  -47.44379 8.66202   1.000 43.87256  ? 70  ALA A CA   1 
ATOM   1067 C C    . ALA A 1 70  ? -6.22501  -47.76547 8.82845   1.000 57.17483  ? 70  ALA A C    1 
ATOM   1068 O O    . ALA A 1 70  ? -5.84232  -48.94346 8.86065   1.000 59.77786  ? 70  ALA A O    1 
ATOM   1069 C CB   . ALA A 1 70  ? -8.56658  -48.26219 9.62110   1.000 49.43263  ? 70  ALA A CB   1 
ATOM   1070 H H    . ALA A 1 70  ? -8.08548  -48.54891 7.08208   1.000 50.18108  ? 70  ALA A H    1 
ATOM   1071 H HA   . ALA A 1 70  ? -7.85772  -46.50772 8.86591   1.000 52.70117  ? 70  ALA A HA   1 
ATOM   1072 H HB1  . ALA A 1 70  ? -8.35433  -48.00657 10.53242  1.000 59.37326  ? 70  ALA A HB1  1 
ATOM   1073 H HB2  . ALA A 1 70  ? -9.50197  -48.08341 9.43674   1.000 59.37326  ? 70  ALA A HB2  1 
ATOM   1074 H HB3  . ALA A 1 70  ? -8.37768  -49.20444 9.48931   1.000 59.37326  ? 70  ALA A HB3  1 
ATOM   1075 N N    . GLY A 1 71  ? -5.39579  -46.73653 8.91235   1.000 54.90902  ? 71  GLY A N    1 
ATOM   1076 C CA   . GLY A 1 71  ? -3.96680  -46.98492 8.86658   1.000 54.09080  ? 71  GLY A CA   1 
ATOM   1077 C C    . GLY A 1 71  ? -3.61076  -47.55421 7.51349   1.000 58.25283  ? 71  GLY A C    1 
ATOM   1078 O O    . GLY A 1 71  ? -4.02781  -47.03577 6.47407   1.000 59.57411  ? 71  GLY A O    1 
ATOM   1079 H H    . GLY A 1 71  ? -5.62690  -45.91216 8.99360   1.000 65.94492  ? 71  GLY A H    1 
ATOM   1080 H HA2  . GLY A 1 71  ? -3.47876  -46.15798 9.00403   1.000 64.96306  ? 71  GLY A HA2  1 
ATOM   1081 H HA3  . GLY A 1 71  ? -3.71497  -47.61864 9.55643   1.000 64.96306  ? 71  GLY A HA3  1 
ATOM   1082 N N    . ASN A 1 72  ? -2.83183  -48.63174 7.50046   1.000 62.31940  ? 72  ASN A N    1 
ATOM   1083 C CA   . ASN A 1 72  ? -2.54638  -49.34894 6.26510   1.000 60.77555  ? 72  ASN A CA   1 
ATOM   1084 C C    . ASN A 1 72  ? -3.61639  -50.38201 5.93475   1.000 65.57421  ? 72  ASN A C    1 
ATOM   1085 O O    . ASN A 1 72  ? -3.53714  -51.01726 4.87856   1.000 63.36409  ? 72  ASN A O    1 
ATOM   1086 C CB   . ASN A 1 72  ? -1.17754  -50.04388 6.34641   1.000 60.33634  ? 72  ASN A CB   1 
ATOM   1087 H H    . ASN A 1 72  ? -2.45626  -48.96699 8.19771   1.000 74.83738  ? 72  ASN A H    1 
ATOM   1088 H HA   . ASN A 1 72  ? -2.50423  -48.70636 5.53969   1.000 72.98476  ? 72  ASN A HA   1 
ATOM   1089 N N    . VAL A 1 73  ? -4.61532  -50.53892 6.80496   1.000 67.54642  ? 73  VAL A N    1 
ATOM   1090 C CA   . VAL A 1 73  ? -5.61435  -51.60227 6.72047   1.000 58.64076  ? 73  VAL A CA   1 
ATOM   1091 C C    . VAL A 1 73  ? -6.81570  -51.11270 5.91266   1.000 60.06527  ? 73  VAL A C    1 
ATOM   1092 O O    . VAL A 1 73  ? -7.47355  -50.13886 6.29464   1.000 50.93911  ? 73  VAL A O    1 
ATOM   1093 C CB   . VAL A 1 73  ? -6.05732  -52.03345 8.13126   1.000 54.48346  ? 73  VAL A CB   1 
ATOM   1094 C CG1  . VAL A 1 73  ? -6.71611  -53.39479 8.10312   1.000 59.98176  ? 73  VAL A CG1  1 
ATOM   1095 C CG2  . VAL A 1 73  ? -4.87298  -52.00572 9.09362   1.000 77.82770  ? 73  VAL A CG2  1 
ATOM   1096 H H    . VAL A 1 73  ? -4.73963  -50.02055 7.47983   1.000 81.10980  ? 73  VAL A H    1 
ATOM   1097 H HA   . VAL A 1 73  ? -5.22895  -52.35835 6.25068   1.000 70.42301  ? 73  VAL A HA   1 
ATOM   1098 H HB   . VAL A 1 73  ? -6.71892  -51.40336 8.45711   1.000 65.43425  ? 73  VAL A HB   1 
ATOM   1099 H HG11 . VAL A 1 73  ? -6.14216  -54.01355 7.62498   1.000 72.03221  ? 73  VAL A HG11 1 
ATOM   1100 H HG12 . VAL A 1 73  ? -6.84671  -53.70133 9.01409   1.000 72.03221  ? 73  VAL A HG12 1 
ATOM   1101 H HG13 . VAL A 1 73  ? -7.57209  -53.32214 7.65264   1.000 72.03221  ? 73  VAL A HG13 1 
ATOM   1102 H HG21 . VAL A 1 73  ? -5.08382  -52.54824 9.86958   1.000 93.44734  ? 73  VAL A HG21 1 
ATOM   1103 H HG22 . VAL A 1 73  ? -4.09154  -52.36243 8.64306   1.000 93.44734  ? 73  VAL A HG22 1 
ATOM   1104 H HG23 . VAL A 1 73  ? -4.70844  -51.08928 9.36558   1.000 93.44734  ? 73  VAL A HG23 1 
ATOM   1105 N N    . GLN A 1 74  ? -7.12719  -51.80540 4.81064   1.000 50.49368  ? 74  GLN A N    1 
ATOM   1106 C CA   . GLN A 1 74  ? -8.30655  -51.45865 4.02119   1.000 48.30357  ? 74  GLN A CA   1 
ATOM   1107 C C    . GLN A 1 74  ? -9.55329  -52.12875 4.58570   1.000 50.92199  ? 74  GLN A C    1 
ATOM   1108 O O    . GLN A 1 74  ? -9.52541  -53.29418 4.99213   1.000 50.41530  ? 74  GLN A O    1 
ATOM   1109 C CB   . GLN A 1 74  ? -8.11851  -51.86324 2.55766   1.000 50.93556  ? 74  GLN A CB   1 
ATOM   1110 C CG   . GLN A 1 74  ? -7.00583  -51.08249 1.84800   1.000 61.60598  ? 74  GLN A CG   1 
ATOM   1111 C CD   . GLN A 1 74  ? -7.48095  -49.81738 1.16024   1.000 52.75214  ? 74  GLN A CD   1 
ATOM   1112 O OE1  . GLN A 1 74  ? -8.67711  -49.51475 1.09633   1.000 52.20987  ? 74  GLN A OE1  1 
ATOM   1113 N NE2  . GLN A 1 74  ? -6.53769  -49.08451 0.59848   1.000 67.70149  ? 74  GLN A NE2  1 
ATOM   1114 H H    . GLN A 1 74  ? -6.67555  -52.47088 4.50608   1.000 60.64652  ? 74  GLN A H    1 
ATOM   1115 H HA   . GLN A 1 74  ? -8.43514  -50.49784 4.05592   1.000 58.01839  ? 74  GLN A HA   1 
ATOM   1116 H HB2  . GLN A 1 74  ? -7.89154  -52.80555 2.51994   1.000 61.17677  ? 74  GLN A HB2  1 
ATOM   1117 H HB3  . GLN A 1 74  ? -8.94683  -51.70210 2.07931   1.000 61.17677  ? 74  GLN A HB3  1 
ATOM   1118 H HG2  . GLN A 1 74  ? -6.33749  -50.82815 2.50339   1.000 73.98127  ? 74  GLN A HG2  1 
ATOM   1119 H HG3  . GLN A 1 74  ? -6.60754  -51.65319 1.17230   1.000 73.98127  ? 74  GLN A HG3  1 
ATOM   1120 H HE21 . GLN A 1 74  ? -5.71644  -49.33663 0.63814   1.000 81.29589  ? 74  GLN A HE21 1 
ATOM   1121 H HE22 . GLN A 1 74  ? -6.74441  -48.35491 0.19283   1.000 81.29589  ? 74  GLN A HE22 1 
ATOM   1122 N N    . LEU A 1 75  ? -10.66142 -51.38231 4.59839   1.000 39.85354  ? 75  LEU A N    1 
ATOM   1123 C CA   . LEU A 1 75  ? -11.92734 -51.87761 5.12039   1.000 40.63107  ? 75  LEU A CA   1 
ATOM   1124 C C    . LEU A 1 75  ? -12.86479 -52.21488 3.97061   1.000 39.66808  ? 75  LEU A C    1 
ATOM   1125 O O    . LEU A 1 75  ? -12.80732 -51.60536 2.90462   1.000 39.15987  ? 75  LEU A O    1 
ATOM   1126 C CB   . LEU A 1 75  ? -12.59566 -50.84759 6.03175   1.000 47.29348  ? 75  LEU A CB   1 
ATOM   1127 C CG   . LEU A 1 75  ? -11.79487 -50.42877 7.26894   1.000 44.33536  ? 75  LEU A CG   1 
ATOM   1128 C CD1  . LEU A 1 75  ? -12.70857 -49.64985 8.22389   1.000 38.62463  ? 75  LEU A CD1  1 
ATOM   1129 C CD2  . LEU A 1 75  ? -11.18618 -51.61104 7.96510   1.000 52.32817  ? 75  LEU A CD2  1 
ATOM   1130 H H    . LEU A 1 75  ? -10.70024 -50.57494 4.30472   1.000 47.87835  ? 75  LEU A H    1 
ATOM   1131 H HA   . LEU A 1 75  ? -11.76381 -52.67884 5.64211   1.000 48.81139  ? 75  LEU A HA   1 
ATOM   1132 H HB2  . LEU A 1 75  ? -12.76176 -50.04580 5.51170   1.000 56.80628  ? 75  LEU A HB2  1 
ATOM   1133 H HB3  . LEU A 1 75  ? -13.43493 -51.21974 6.34484   1.000 56.80628  ? 75  LEU A HB3  1 
ATOM   1134 H HG   . LEU A 1 75  ? -11.05987 -49.85956 6.99202   1.000 53.25654  ? 75  LEU A HG   1 
ATOM   1135 H HD11 . LEU A 1 75  ? -13.07643 -48.88453 7.75500   1.000 46.40366  ? 75  LEU A HD11 1 
ATOM   1136 H HD12 . LEU A 1 75  ? -13.42553 -50.23216 8.52019   1.000 46.40366  ? 75  LEU A HD12 1 
ATOM   1137 H HD13 . LEU A 1 75  ? -12.18803 -49.35185 8.98621   1.000 46.40366  ? 75  LEU A HD13 1 
ATOM   1138 H HD21 . LEU A 1 75  ? -10.84444 -51.32811 8.82769   1.000 62.84791  ? 75  LEU A HD21 1 
ATOM   1139 H HD22 . LEU A 1 75  ? -11.86700 -52.29131 8.08598   1.000 62.84791  ? 75  LEU A HD22 1 
ATOM   1140 H HD23 . LEU A 1 75  ? -10.46288 -51.95995 7.42103   1.000 62.84791  ? 75  LEU A HD23 1 
ATOM   1141 N N    . ARG A 1 76  ? -13.73716 -53.19544 4.20387   1.000 36.50051  ? 76  ARG A N    1 
ATOM   1142 C CA   . ARG A 1 76  ? -14.65285 -53.68896 3.18427   1.000 47.84406  ? 76  ARG A CA   1 
ATOM   1143 C C    . ARG A 1 76  ? -16.02518 -53.04706 3.38364   1.000 42.83845  ? 76  ARG A C    1 
ATOM   1144 O O    . ARG A 1 76  ? -16.64620 -53.22693 4.42591   1.000 37.11244  ? 76  ARG A O    1 
ATOM   1145 C CB   . ARG A 1 76  ? -14.73675 -55.21913 3.24114   1.000 52.06716  ? 76  ARG A CB   1 
ATOM   1146 C CG   . ARG A 1 76  ? -15.43815 -55.83396 2.04104   1.000 59.19962  ? 76  ARG A CG   1 
ATOM   1147 C CD   . ARG A 1 76  ? -15.47880 -57.36516 2.12227   1.000 52.07383  ? 76  ARG A CD   1 
ATOM   1148 N NE   . ARG A 1 76  ? -14.15031 -57.95420 2.01532   1.000 48.77725  ? 76  ARG A NE   1 
ATOM   1149 C CZ   . ARG A 1 76  ? -13.50651 -58.17533 0.87354   1.000 41.09947  ? 76  ARG A CZ   1 
ATOM   1150 N NH1  . ARG A 1 76  ? -14.04021 -57.86177 -0.29648  1.000 50.57673  ? 76  ARG A NH1  1 
ATOM   1151 N NH2  . ARG A 1 76  ? -12.28287 -58.68968 0.91454   1.000 39.65113  ? 76  ARG A NH2  1 
ATOM   1152 H H    . ARG A 1 76  ? -13.81636 -53.59614 4.96068   1.000 43.85471  ? 76  ARG A H    1 
ATOM   1153 H HA   . ARG A 1 76  ? -14.33651 -53.43374 2.30354   1.000 57.46697  ? 76  ARG A HA   1 
ATOM   1154 H HB2  . ARG A 1 76  ? -13.83724 -55.58040 3.27667   1.000 62.53469  ? 76  ARG A HB2  1 
ATOM   1155 H HB3  . ARG A 1 76  ? -15.22903 -55.47584 4.03654   1.000 62.53469  ? 76  ARG A HB3  1 
ATOM   1156 H HG2  . ARG A 1 76  ? -16.35108 -55.50836 2.00315   1.000 71.09365  ? 76  ARG A HG2  1 
ATOM   1157 H HG3  . ARG A 1 76  ? -14.96368 -55.58610 1.23212   1.000 71.09365  ? 76  ARG A HG3  1 
ATOM   1158 H HD2  . ARG A 1 76  ? -15.85939 -57.62939 2.97446   1.000 62.54269  ? 76  ARG A HD2  1 
ATOM   1159 H HD3  . ARG A 1 76  ? -16.02172 -57.70884 1.39562   1.000 62.54269  ? 76  ARG A HD3  1 
ATOM   1160 H HE   . ARG A 1 76  ? -13.75311 -58.17527 2.74536   1.000 58.58680  ? 76  ARG A HE   1 
ATOM   1161 H HH11 . ARG A 1 76  ? -14.82228 -57.50568 -0.33079  1.000 60.74618  ? 76  ARG A HH11 1 
ATOM   1162 H HH12 . ARG A 1 76  ? -13.60490 -58.01414 -1.02235  1.000 60.74618  ? 76  ARG A HH12 1 
ATOM   1163 H HH21 . ARG A 1 76  ? -11.91915 -58.87424 1.67167   1.000 47.63546  ? 76  ARG A HH21 1 
ATOM   1164 H HH22 . ARG A 1 76  ? -11.85415 -58.83820 0.18397   1.000 47.63546  ? 76  ARG A HH22 1 
ATOM   1165 N N    . VAL A 1 77  ? -16.48877 -52.32411 2.37268   1.000 39.94049  ? 77  VAL A N    1 
ATOM   1166 C CA   . VAL A 1 77  ? -17.73496 -51.56719 2.43074   1.000 40.24191  ? 77  VAL A CA   1 
ATOM   1167 C C    . VAL A 1 77  ? -18.86654 -52.40566 1.85943   1.000 42.48396  ? 77  VAL A C    1 
ATOM   1168 O O    . VAL A 1 77  ? -18.79334 -52.85088 0.70741   1.000 40.54578  ? 77  VAL A O    1 
ATOM   1169 C CB   . VAL A 1 77  ? -17.60554 -50.25948 1.63753   1.000 40.58399  ? 77  VAL A CB   1 
ATOM   1170 C CG1  . VAL A 1 77  ? -18.94923 -49.53834 1.59173   1.000 35.80340  ? 77  VAL A CG1  1 
ATOM   1171 C CG2  . VAL A 1 77  ? -16.50265 -49.42092 2.19847   1.000 40.94683  ? 77  VAL A CG2  1 
ATOM   1172 H H    . VAL A 1 77  ? -16.08680 -52.25271 1.61576   1.000 47.98269  ? 77  VAL A H    1 
ATOM   1173 H HA   . VAL A 1 77  ? -17.93523 -51.36993 3.35912   1.000 48.34439  ? 77  VAL A HA   1 
ATOM   1174 H HB   . VAL A 1 77  ? -17.36333 -50.44653 0.71707   1.000 48.75489  ? 77  VAL A HB   1 
ATOM   1175 H HG11 . VAL A 1 77  ? -19.46194 -49.77547 2.38028   1.000 43.01818  ? 77  VAL A HG11 1 
ATOM   1176 H HG12 . VAL A 1 77  ? -18.79346 -48.58110 1.57397   1.000 43.01818  ? 77  VAL A HG12 1 
ATOM   1177 H HG13 . VAL A 1 77  ? -19.42670 -49.81065 0.79250   1.000 43.01818  ? 77  VAL A HG13 1 
ATOM   1178 H HG21 . VAL A 1 77  ? -16.51707 -48.55149 1.76861   1.000 49.19030  ? 77  VAL A HG21 1 
ATOM   1179 H HG22 . VAL A 1 77  ? -16.63732 -49.31989 3.15375   1.000 49.19030  ? 77  VAL A HG22 1 
ATOM   1180 H HG23 . VAL A 1 77  ? -15.65450 -49.85988 2.02859   1.000 49.19030  ? 77  VAL A HG23 1 
ATOM   1181 N N    . ILE A 1 78  ? -19.93289 -52.55591 2.63183   1.000 41.09356  ? 78  ILE A N    1 
ATOM   1182 C CA   . ILE A 1 78  ? -21.03807 -53.45939 2.35230   1.000 37.04210  ? 78  ILE A CA   1 
ATOM   1183 C C    . ILE A 1 78  ? -22.36248 -52.73525 2.24144   1.000 42.86324  ? 78  ILE A C    1 
ATOM   1184 O O    . ILE A 1 78  ? -23.39327 -53.37886 2.03785   1.000 38.24420  ? 78  ILE A O    1 
ATOM   1185 C CB   . ILE A 1 78  ? -21.08254 -54.57405 3.41537   1.000 36.39063  ? 78  ILE A CB   1 
ATOM   1186 C CG1  . ILE A 1 78  ? -21.33026 -54.02099 4.80908   1.000 42.87647  ? 78  ILE A CG1  1 
ATOM   1187 C CG2  . ILE A 1 78  ? -19.72797 -55.29277 3.46222   1.000 43.55835  ? 78  ILE A CG2  1 
ATOM   1188 C CD1  . ILE A 1 78  ? -21.33271 -55.10359 5.89275   1.000 46.61775  ? 78  ILE A CD1  1 
ATOM   1189 H H    . ILE A 1 78  ? -20.04537 -52.12061 3.36495   1.000 49.36637  ? 78  ILE A H    1 
ATOM   1190 H HA   . ILE A 1 78  ? -20.90511 -53.88461 1.49066   1.000 44.50462  ? 78  ILE A HA   1 
ATOM   1191 H HB   . ILE A 1 78  ? -21.80640 -55.16919 3.16490   1.000 43.72286  ? 78  ILE A HB   1 
ATOM   1192 H HG12 . ILE A 1 78  ? -20.63050 -53.38453 5.02388   1.000 51.50587  ? 78  ILE A HG12 1 
ATOM   1193 H HG13 . ILE A 1 78  ? -22.19470 -53.58118 4.82389   1.000 51.50587  ? 78  ILE A HG13 1 
ATOM   1194 H HG21 . ILE A 1 78  ? -19.07805 -54.71404 3.89068   1.000 52.32412  ? 78  ILE A HG21 1 
ATOM   1195 H HG22 . ILE A 1 78  ? -19.82382 -56.11449 3.96868   1.000 52.32412  ? 78  ILE A HG22 1 
ATOM   1196 H HG23 . ILE A 1 78  ? -19.44554 -55.49363 2.55625   1.000 52.32412  ? 78  ILE A HG23 1 
ATOM   1197 H HD11 . ILE A 1 78  ? -20.42174 -55.39990 6.04517   1.000 55.99540  ? 78  ILE A HD11 1 
ATOM   1198 H HD12 . ILE A 1 78  ? -21.70070 -54.73188 6.70964   1.000 55.99540  ? 78  ILE A HD12 1 
ATOM   1199 H HD13 . ILE A 1 78  ? -21.87720 -55.84856 5.59367   1.000 55.99540  ? 78  ILE A HD13 1 
ATOM   1200 N N    . GLY A 1 79  ? -22.35933 -51.42526 2.32791   1.000 39.22453  ? 79  GLY A N    1 
ATOM   1201 C CA   . GLY A 1 79  ? -23.57283 -50.66236 2.31000   1.000 33.09063  ? 79  GLY A CA   1 
ATOM   1202 C C    . GLY A 1 79  ? -23.27048 -49.19052 2.38246   1.000 37.53896  ? 79  GLY A C    1 
ATOM   1203 O O    . GLY A 1 79  ? -22.22889 -48.78778 2.91273   1.000 34.21542  ? 79  GLY A O    1 
ATOM   1204 H H    . GLY A 1 79  ? -21.64849 -50.94651 2.39937   1.000 47.12354  ? 79  GLY A H    1 
ATOM   1205 H HA2  . GLY A 1 79  ? -24.06177 -50.84251 1.49183   1.000 39.76285  ? 79  GLY A HA2  1 
ATOM   1206 H HA3  . GLY A 1 79  ? -24.12560 -50.90703 3.06861   1.000 39.76285  ? 79  GLY A HA3  1 
ATOM   1207 N N    . HIS A 1 80  ? -24.12263 -48.38098 1.76959   1.000 38.43367  ? 80  HIS A N    1 
ATOM   1208 C CA   . HIS A 1 80  ? -23.93320 -46.93978 1.82124   1.000 35.76701  ? 80  HIS A CA   1 
ATOM   1209 C C    . HIS A 1 80  ? -25.28223 -46.24185 1.82621   1.000 39.08601  ? 80  HIS A C    1 
ATOM   1210 O O    . HIS A 1 80  ? -26.23422 -46.71473 1.19827   1.000 34.64513  ? 80  HIS A O    1 
ATOM   1211 C CB   . HIS A 1 80  ? -23.05315 -46.45993 0.66489   1.000 37.18820  ? 80  HIS A CB   1 
ATOM   1212 C CG   . HIS A 1 80  ? -23.65999 -46.59778 -0.70667  1.000 40.47851  ? 80  HIS A CG   1 
ATOM   1213 N ND1  . HIS A 1 80  ? -23.52607 -47.74252 -1.46869  1.000 42.95648  ? 80  HIS A ND1  1 
ATOM   1214 C CD2  . HIS A 1 80  ? -24.31799 -45.70541 -1.48548  1.000 39.23650  ? 80  HIS A CD2  1 
ATOM   1215 C CE1  . HIS A 1 80  ? -24.10128 -47.55642 -2.64718  1.000 38.84107  ? 80  HIS A CE1  1 
ATOM   1216 N NE2  . HIS A 1 80  ? -24.59489 -46.33442 -2.68112  1.000 38.94580  ? 80  HIS A NE2  1 
ATOM   1217 H H    . HIS A 1 80  ? -24.81038 -48.63931 1.32254   1.000 46.17450  ? 80  HIS A H    1 
ATOM   1218 H HA   . HIS A 1 80  ? -23.49371 -46.69568 2.65080   1.000 42.97452  ? 80  HIS A HA   1 
ATOM   1219 H HB2  . HIS A 1 80  ? -22.85543 -45.52006 0.80069   1.000 44.67994  ? 80  HIS A HB2  1 
ATOM   1220 H HB3  . HIS A 1 80  ? -22.23185 -46.97600 0.67111   1.000 44.67994  ? 80  HIS A HB3  1 
ATOM   1221 H HD1  . HIS A 1 80  ? -23.13076 -48.46361 -1.21699  1.000 51.60188  ? 80  HIS A HD1  1 
ATOM   1222 H HD2  . HIS A 1 80  ? -24.54116 -44.83209 -1.25657  1.000 47.13790  ? 80  HIS A HD2  1 
ATOM   1223 H HE1  . HIS A 1 80  ? -24.14887 -48.18159 -3.33405  1.000 46.66338  ? 80  HIS A HE1  1 
ATOM   1224 N N    . SER A 1 81  ? -25.35198 -45.11565 2.55648   1.000 35.19205  ? 81  SER A N    1 
ATOM   1225 C CA   . SER A 1 81  ? -26.56792 -44.32455 2.65476   1.000 35.77827  ? 81  SER A CA   1 
ATOM   1226 C C    . SER A 1 81  ? -26.18694 -42.85450 2.82623   1.000 38.77360  ? 81  SER A C    1 
ATOM   1227 O O    . SER A 1 81  ? -25.10558 -42.52914 3.33026   1.000 35.21964  ? 81  SER A O    1 
ATOM   1228 C CB   . SER A 1 81  ? -27.42798 -44.79090 3.84189   1.000 33.08507  ? 81  SER A CB   1 
ATOM   1229 O OG   . SER A 1 81  ? -28.51690 -43.89715 4.04731   1.000 62.38048  ? 81  SER A OG   1 
ATOM   1230 H H    . SER A 1 81  ? -24.69415 -44.79286 3.00667   1.000 42.28456  ? 81  SER A H    1 
ATOM   1231 H HA   . SER A 1 81  ? -27.08784 -44.40961 1.84030   1.000 42.98803  ? 81  SER A HA   1 
ATOM   1232 H HB2  . SER A 1 81  ? -27.77546 -45.67673 3.65359   1.000 39.75619  ? 81  SER A HB2  1 
ATOM   1233 H HB3  . SER A 1 81  ? -26.87985 -44.81268 4.64187   1.000 39.75619  ? 81  SER A HB3  1 
ATOM   1234 H HG   . SER A 1 81  ? -28.98195 -44.15553 4.69736   1.000 74.91067  ? 81  SER A HG   1 
ATOM   1235 N N    . MET A 1 82  ? -27.06114 -41.97479 2.36972   1.000 33.61860  ? 82  MET A N    1 
ATOM   1236 C CA   . MET A 1 82  ? -26.89732 -40.54693 2.57149   1.000 32.12075  ? 82  MET A CA   1 
ATOM   1237 C C    . MET A 1 82  ? -27.92766 -40.07399 3.58169   1.000 34.49500  ? 82  MET A C    1 
ATOM   1238 O O    . MET A 1 82  ? -29.13149 -40.29927 3.40027   1.000 37.19244  ? 82  MET A O    1 
ATOM   1239 C CB   . MET A 1 82  ? -27.03806 -39.78520 1.25566   1.000 31.55745  ? 82  MET A CB   1 
ATOM   1240 C CG   . MET A 1 82  ? -26.86166 -38.29902 1.38897   1.000 33.41187  ? 82  MET A CG   1 
ATOM   1241 S SD   . MET A 1 82  ? -26.63480 -37.42916 -0.15019  1.000 34.74959  ? 82  MET A SD   1 
ATOM   1242 C CE   . MET A 1 82  ? -28.19823 -37.68884 -0.99292  1.000 47.32440  ? 82  MET A CE   1 
ATOM   1243 H H    . MET A 1 82  ? -27.77071 -42.18517 1.93172   1.000 40.39642  ? 82  MET A H    1 
ATOM   1244 H HA   . MET A 1 82  ? -26.00868 -40.37485 2.92022   1.000 38.59900  ? 82  MET A HA   1 
ATOM   1245 H HB2  . MET A 1 82  ? -26.36525 -40.10798 0.63596   1.000 37.92304  ? 82  MET A HB2  1 
ATOM   1246 H HB3  . MET A 1 82  ? -27.92456 -39.94626 0.89637   1.000 37.92304  ? 82  MET A HB3  1 
ATOM   1247 H HG2  . MET A 1 82  ? -27.65144 -37.93245 1.81650   1.000 40.14834  ? 82  MET A HG2  1 
ATOM   1248 H HG3  . MET A 1 82  ? -26.07918 -38.12984 1.93669   1.000 40.14834  ? 82  MET A HG3  1 
ATOM   1249 H HE1  . MET A 1 82  ? -28.14980 -37.29332 -1.87729  1.000 56.84338  ? 82  MET A HE1  1 
ATOM   1250 H HE2  . MET A 1 82  ? -28.36343 -38.64192 -1.06541  1.000 56.84338  ? 82  MET A HE2  1 
ATOM   1251 H HE3  . MET A 1 82  ? -28.90666 -37.26835 -0.48085  1.000 56.84338  ? 82  MET A HE3  1 
ATOM   1252 N N    . GLN A 1 83  ? -27.44674 -39.44423 4.65555   1.000 32.35922  ? 83  GLN A N    1 
ATOM   1253 C CA   . GLN A 1 83  ? -28.25724 -38.86289 5.72112   1.000 34.86713  ? 83  GLN A CA   1 
ATOM   1254 C C    . GLN A 1 83  ? -27.88620 -37.38706 5.75322   1.000 28.59839  ? 83  GLN A C    1 
ATOM   1255 O O    . GLN A 1 83  ? -26.79088 -37.03980 6.21078   1.000 29.20925  ? 83  GLN A O    1 
ATOM   1256 C CB   . GLN A 1 83  ? -27.99840 -39.52208 7.07246   1.000 29.28202  ? 83  GLN A CB   1 
ATOM   1257 C CG   . GLN A 1 83  ? -28.71198 -38.82551 8.21120   1.000 32.50734  ? 83  GLN A CG   1 
ATOM   1258 C CD   . GLN A 1 83  ? -28.54459 -39.49045 9.57221   1.000 35.66788  ? 83  GLN A CD   1 
ATOM   1259 O OE1  . GLN A 1 83  ? -27.61014 -40.27241 9.80545   1.000 37.28747  ? 83  GLN A OE1  1 
ATOM   1260 N NE2  . GLN A 1 83  ? -29.45509 -39.17719 10.48723  1.000 39.50770  ? 83  GLN A NE2  1 
ATOM   1261 H H    . GLN A 1 83  ? -26.60493 -39.33637 4.79451   1.000 38.88516  ? 83  GLN A H    1 
ATOM   1262 H HA   . GLN A 1 83  ? -29.20133 -38.97920 5.53125   1.000 41.89466  ? 83  GLN A HA   1 
ATOM   1263 H HB2  . GLN A 1 83  ? -28.30933 -40.44033 7.04027   1.000 35.19253  ? 83  GLN A HB2  1 
ATOM   1264 H HB3  . GLN A 1 83  ? -27.04632 -39.50047 7.25682   1.000 35.19253  ? 83  GLN A HB3  1 
ATOM   1265 H HG2  . GLN A 1 83  ? -28.36720 -37.92180 8.28420   1.000 39.06291  ? 83  GLN A HG2  1 
ATOM   1266 H HG3  . GLN A 1 83  ? -29.66118 -38.80342 8.01262   1.000 39.06291  ? 83  GLN A HG3  1 
ATOM   1267 H HE21 . GLN A 1 83  ? -30.08883 -38.62915 10.29322  1.000 47.46335  ? 83  GLN A HE21 1 
ATOM   1268 H HE22 . GLN A 1 83  ? -29.41085 -39.52240 11.27366  1.000 47.46335  ? 83  GLN A HE22 1 
ATOM   1269 N N    . ASN A 1 84  ? -28.79351 -36.52835 5.25966   1.000 31.48943  ? 84  ASN A N    1 
ATOM   1270 C CA   . ASN A 1 84  ? -28.56313 -35.09380 5.19145   1.000 29.01883  ? 84  ASN A CA   1 
ATOM   1271 C C    . ASN A 1 84  ? -27.23196 -34.86345 4.44429   1.000 30.02289  ? 84  ASN A C    1 
ATOM   1272 O O    . ASN A 1 84  ? -27.06783 -35.38436 3.31876   1.000 33.45404  ? 84  ASN A O    1 
ATOM   1273 C CB   . ASN A 1 84  ? -28.63984 -34.50343 6.59157   1.000 30.14090  ? 84  ASN A CB   1 
ATOM   1274 C CG   . ASN A 1 84  ? -30.00857 -34.76386 7.23724   1.000 32.13723  ? 84  ASN A CG   1 
ATOM   1275 O OD1  . ASN A 1 84  ? -31.03754 -34.48774 6.63177   1.000 33.09825  ? 84  ASN A OD1  1 
ATOM   1276 N ND2  . ASN A 1 84  ? -30.00952 -35.36061 8.41523   1.000 32.64850  ? 84  ASN A ND2  1 
ATOM   1277 H H    . ASN A 1 84  ? -29.56192 -36.76512 4.95455   1.000 37.84142  ? 84  ASN A H    1 
ATOM   1278 H HA   . ASN A 1 84  ? -29.24134 -34.61296 4.69174   1.000 34.87670  ? 84  ASN A HA   1 
ATOM   1279 H HB2  . ASN A 1 84  ? -27.95723 -34.90894 7.14879   1.000 36.22318  ? 84  ASN A HB2  1 
ATOM   1280 H HB3  . ASN A 1 84  ? -28.50237 -33.54442 6.54355   1.000 36.22318  ? 84  ASN A HB3  1 
ATOM   1281 H HD21 . ASN A 1 84  ? -30.75391 -35.52584 8.81295   1.000 39.23230  ? 84  ASN A HD21 1 
ATOM   1282 H HD22 . ASN A 1 84  ? -29.26575 -35.58401 8.78468   1.000 39.23230  ? 84  ASN A HD22 1 
ATOM   1283 N N    . CYS A 1 85  ? -26.27985 -34.15429 5.03368   1.000 26.52913  ? 85  CYS A N    1 
ATOM   1284 C CA   . CYS A 1 85  ? -25.03217 -33.86536 4.32377   1.000 25.89389  ? 85  CYS A CA   1 
ATOM   1285 C C    . CYS A 1 85  ? -23.88529 -34.83464 4.64737   1.000 30.81671  ? 85  CYS A C    1 
ATOM   1286 O O    . CYS A 1 85  ? -22.73884 -34.53759 4.31624   1.000 26.64435  ? 85  CYS A O    1 
ATOM   1287 C CB   . CYS A 1 85  ? -24.60864 -32.43263 4.61539   1.000 28.22234  ? 85  CYS A CB   1 
ATOM   1288 S SG   . CYS A 1 85  ? -25.82963 -31.30245 4.02784   1.000 30.94921  ? 85  CYS A SG   1 
ATOM   1289 H H    . CYS A 1 85  ? -26.32832 -33.83337 5.83008   1.000 31.88906  ? 85  CYS A H    1 
ATOM   1290 H HA   . CYS A 1 85  ? -25.20401 -33.96048 3.37386   1.000 31.12677  ? 85  CYS A HA   1 
ATOM   1291 H HB2  . CYS A 1 85  ? -24.50813 -32.31179 5.57257   1.000 33.92091  ? 85  CYS A HB2  1 
ATOM   1292 H HB3  . CYS A 1 85  ? -23.76927 -32.24416 4.16725   1.000 33.92091  ? 85  CYS A HB3  1 
ATOM   1293 H HG   . CYS A 1 85  ? -25.85533 -31.34360 2.82883   1.000 37.19315  ? 85  CYS A HG   1 
ATOM   1294 N N    . VAL A 1 86  ? -24.15604 -35.98073 5.24160   1.000 26.64525  ? 86  VAL A N    1 
ATOM   1295 C CA   . VAL A 1 86  ? -23.12964 -36.99072 5.51144   1.000 29.16760  ? 86  VAL A CA   1 
ATOM   1296 C C    . VAL A 1 86  ? -23.49978 -38.30000 4.83508   1.000 33.18506  ? 86  VAL A C    1 
ATOM   1297 O O    . VAL A 1 86  ? -24.67603 -38.64249 4.68120   1.000 31.18901  ? 86  VAL A O    1 
ATOM   1298 C CB   . VAL A 1 86  ? -22.83592 -37.31800 7.00457   1.000 31.95232  ? 86  VAL A CB   1 
ATOM   1299 C CG1  . VAL A 1 86  ? -22.26423 -36.07779 7.75027   1.000 34.44577  ? 86  VAL A CG1  1 
ATOM   1300 C CG2  . VAL A 1 86  ? -24.06284 -37.91147 7.70939   1.000 34.79039  ? 86  VAL A CG2  1 
ATOM   1301 H H    . VAL A 1 86  ? -24.94160 -36.20912 5.50680   1.000 32.02840  ? 86  VAL A H    1 
ATOM   1302 H HA   . VAL A 1 86  ? -22.32683 -36.59979 5.13252   1.000 35.05522  ? 86  VAL A HA   1 
ATOM   1303 H HB   . VAL A 1 86  ? -22.15025 -38.00346 7.03456   1.000 38.39689  ? 86  VAL A HB   1 
ATOM   1304 H HG11 . VAL A 1 86  ? -22.62623 -35.27281 7.34795   1.000 41.38903  ? 86  VAL A HG11 1 
ATOM   1305 H HG12 . VAL A 1 86  ? -22.52099 -36.12493 8.68448   1.000 41.38903  ? 86  VAL A HG12 1 
ATOM   1306 H HG13 . VAL A 1 86  ? -21.29736 -36.08047 7.67242   1.000 41.38903  ? 86  VAL A HG13 1 
ATOM   1307 H HG21 . VAL A 1 86  ? -23.82023 -38.15103 8.61749   1.000 41.80258  ? 86  VAL A HG21 1 
ATOM   1308 H HG22 . VAL A 1 86  ? -24.77181 -37.24955 7.72009   1.000 41.80258  ? 86  VAL A HG22 1 
ATOM   1309 H HG23 . VAL A 1 86  ? -24.35404 -38.70028 7.22578   1.000 41.80258  ? 86  VAL A HG23 1 
ATOM   1310 N N    . LEU A 1 87  ? -22.45002 -39.04031 4.46492   1.000 30.87211  ? 87  LEU A N    1 
ATOM   1311 C CA   . LEU A 1 87  ? -22.55524 -40.43865 4.07691   1.000 37.38412  ? 87  LEU A CA   1 
ATOM   1312 C C    . LEU A 1 87  ? -22.28095 -41.33307 5.26650   1.000 32.71068  ? 87  LEU A C    1 
ATOM   1313 O O    . LEU A 1 87  ? -21.41625 -41.04149 6.09808   1.000 31.59464  ? 87  LEU A O    1 
ATOM   1314 C CB   . LEU A 1 87  ? -21.53205 -40.78619 2.98527   1.000 34.69760  ? 87  LEU A CB   1 
ATOM   1315 C CG   . LEU A 1 87  ? -21.68805 -40.08490 1.65648   1.000 41.46182  ? 87  LEU A CG   1 
ATOM   1316 C CD1  . LEU A 1 87  ? -20.66611 -40.68774 0.67459   1.000 41.42736  ? 87  LEU A CD1  1 
ATOM   1317 C CD2  . LEU A 1 87  ? -23.13049 -40.19736 1.18615   1.000 40.02831  ? 87  LEU A CD2  1 
ATOM   1318 H H    . LEU A 1 87  ? -21.64446 -38.74109 4.43125   1.000 37.10063  ? 87  LEU A H    1 
ATOM   1319 H HA   . LEU A 1 87  ? -23.45173 -40.59665 3.74189   1.000 44.91504  ? 87  LEU A HA   1 
ATOM   1320 H HB2  . LEU A 1 87  ? -20.64944 -40.56451 3.32106   1.000 41.69122  ? 87  LEU A HB2  1 
ATOM   1321 H HB3  . LEU A 1 87  ? -21.59147 -41.73873 2.81194   1.000 41.69122  ? 87  LEU A HB3  1 
ATOM   1322 H HG   . LEU A 1 87  ? -21.50465 -39.13423 1.71559   1.000 49.80829  ? 87  LEU A HG   1 
ATOM   1323 H HD11 . LEU A 1 87  ? -20.85350 -40.35804 -0.21820  1.000 49.76693  ? 87  LEU A HD11 1 
ATOM   1324 H HD12 . LEU A 1 87  ? -19.77340 -40.42151 0.94492   1.000 49.76693  ? 87  LEU A HD12 1 
ATOM   1325 H HD13 . LEU A 1 87  ? -20.74278 -41.65453 0.69303   1.000 49.76693  ? 87  LEU A HD13 1 
ATOM   1326 H HD21 . LEU A 1 87  ? -23.16922 -40.00221 0.23678   1.000 48.08807  ? 87  LEU A HD21 1 
ATOM   1327 H HD22 . LEU A 1 87  ? -23.44723 -41.09913 1.35167   1.000 48.08807  ? 87  LEU A HD22 1 
ATOM   1328 H HD23 . LEU A 1 87  ? -23.67329 -39.56078 1.67711   1.000 48.08807  ? 87  LEU A HD23 1 
ATOM   1329 N N    . LYS A 1 88  ? -23.00933 -42.44300 5.34895   1.000 29.47530  ? 88  LYS A N    1 
ATOM   1330 C CA   . LYS A 1 88  ? -22.75384 -43.52658 6.26621   1.000 28.86665  ? 88  LYS A CA   1 
ATOM   1331 C C    . LYS A 1 88  ? -22.35002 -44.71372 5.40654   1.000 35.60636  ? 88  LYS A C    1 
ATOM   1332 O O    . LYS A 1 88  ? -23.13354 -45.15058 4.55619   1.000 36.70240  ? 88  LYS A O    1 
ATOM   1333 C CB   . LYS A 1 88  ? -23.99627 -43.82823 7.10115   1.000 37.68205  ? 88  LYS A CB   1 
ATOM   1334 C CG   . LYS A 1 88  ? -24.51150 -42.56612 7.78711   1.000 41.30428  ? 88  LYS A CG   1 
ATOM   1335 C CD   . LYS A 1 88  ? -25.45121 -42.85427 8.93151   1.000 39.87834  ? 88  LYS A CD   1 
ATOM   1336 C CE   . LYS A 1 88  ? -26.74541 -43.51914 8.49900   1.000 41.84807  ? 88  LYS A CE   1 
ATOM   1337 N NZ   . LYS A 1 88  ? -27.86991 -43.14228 9.40629   1.000 40.48663  ? 88  LYS A NZ   1 
ATOM   1338 H H    . LYS A 1 88  ? -23.69462 -42.59132 4.85098   1.000 35.42446  ? 88  LYS A H    1 
ATOM   1339 H HA   . LYS A 1 88  ? -22.03937 -43.31717 6.88797   1.000 34.69408  ? 88  LYS A HA   1 
ATOM   1340 H HB2  . LYS A 1 88  ? -24.69620 -44.17342 6.52509   1.000 45.27257  ? 88  LYS A HB2  1 
ATOM   1341 H HB3  . LYS A 1 88  ? -23.77579 -44.48156 7.78338   1.000 45.27257  ? 88  LYS A HB3  1 
ATOM   1342 H HG2  . LYS A 1 88  ? -23.75692 -42.06874 8.13940   1.000 49.61923  ? 88  LYS A HG2  1 
ATOM   1343 H HG3  . LYS A 1 88  ? -24.98974 -42.02746 7.13747   1.000 49.61923  ? 88  LYS A HG3  1 
ATOM   1344 H HD2  . LYS A 1 88  ? -25.00879 -43.44702 9.55904   1.000 47.90811  ? 88  LYS A HD2  1 
ATOM   1345 H HD3  . LYS A 1 88  ? -25.67886 -42.01871 9.36845   1.000 47.90811  ? 88  LYS A HD3  1 
ATOM   1346 H HE2  . LYS A 1 88  ? -26.96900 -43.23570 7.59869   1.000 50.27179  ? 88  LYS A HE2  1 
ATOM   1347 H HE3  . LYS A 1 88  ? -26.63837 -44.48282 8.52648   1.000 50.27179  ? 88  LYS A HE3  1 
ATOM   1348 H HZ1  . LYS A 1 88  ? -27.73201 -43.47957 10.21828  1.000 48.63806  ? 88  LYS A HZ1  1 
ATOM   1349 H HZ2  . LYS A 1 88  ? -27.92775 -42.25628 9.46757   1.000 48.63806  ? 88  LYS A HZ2  1 
ATOM   1350 H HZ3  . LYS A 1 88  ? -28.63766 -43.46052 9.08790   1.000 48.63806  ? 88  LYS A HZ3  1 
ATOM   1351 N N    . LEU A 1 89  ? -21.12880 -45.17261 5.56813   1.000 31.77813  ? 89  LEU A N    1 
ATOM   1352 C CA   . LEU A 1 89  ? -20.62659 -46.36395 4.88752   1.000 34.10780  ? 89  LEU A CA   1 
ATOM   1353 C C    . LEU A 1 89  ? -20.61185 -47.49992 5.88726   1.000 35.42291  ? 89  LEU A C    1 
ATOM   1354 O O    . LEU A 1 89  ? -19.93727 -47.40984 6.92578   1.000 34.54417  ? 89  LEU A O    1 
ATOM   1355 C CB   . LEU A 1 89  ? -19.22997 -46.11733 4.32744   1.000 32.85695  ? 89  LEU A CB   1 
ATOM   1356 C CG   . LEU A 1 89  ? -19.09794 -44.81655 3.56316   1.000 32.67060  ? 89  LEU A CG   1 
ATOM   1357 C CD1  . LEU A 1 89  ? -17.63810 -44.56562 3.18324   1.000 33.54502  ? 89  LEU A CD1  1 
ATOM   1358 C CD2  . LEU A 1 89  ? -19.99778 -44.85469 2.30366   1.000 32.27518  ? 89  LEU A CD2  1 
ATOM   1359 H H    . LEU A 1 89  ? -20.54606 -44.80466 6.08256   1.000 38.18785  ? 89  LEU A H    1 
ATOM   1360 H HA   . LEU A 1 89  ? -21.20778 -46.60023 4.14774   1.000 40.98346  ? 89  LEU A HA   1 
ATOM   1361 H HB2  . LEU A 1 89  ? -18.59935 -46.09366 5.06409   1.000 39.48244  ? 89  LEU A HB2  1 
ATOM   1362 H HB3  . LEU A 1 89  ? -19.00566 -46.84107 3.72182   1.000 39.48244  ? 89  LEU A HB3  1 
ATOM   1363 H HG   . LEU A 1 89  ? -19.38715 -44.07873 4.12253   1.000 39.25883  ? 89  LEU A HG   1 
ATOM   1364 H HD11 . LEU A 1 89  ? -17.51817 -43.62132 2.99664   1.000 40.30813  ? 89  LEU A HD11 1 
ATOM   1365 H HD12 . LEU A 1 89  ? -17.06919 -44.83158 3.92250   1.000 40.30813  ? 89  LEU A HD12 1 
ATOM   1366 H HD13 . LEU A 1 89  ? -17.42251 -45.08851 2.39519   1.000 40.30813  ? 89  LEU A HD13 1 
ATOM   1367 H HD21 . LEU A 1 89  ? -19.88701 -44.02638 1.81119   1.000 38.78432  ? 89  LEU A HD21 1 
ATOM   1368 H HD22 . LEU A 1 89  ? -19.73445 -45.60641 1.75005   1.000 38.78432  ? 89  LEU A HD22 1 
ATOM   1369 H HD23 . LEU A 1 89  ? -20.92247 -44.95463 2.57909   1.000 38.78432  ? 89  LEU A HD23 1 
ATOM   1370 N N    . LYS A 1 90  ? -21.37664 -48.55550 5.59933   1.000 35.77493  ? 90  LYS A N    1 
ATOM   1371 C CA   . LYS A 1 90  ? -21.38139 -49.74371 6.43643   1.000 31.75172  ? 90  LYS A CA   1 
ATOM   1372 C C    . LYS A 1 90  ? -20.17325 -50.57588 6.04349   1.000 34.12122  ? 90  LYS A C    1 
ATOM   1373 O O    . LYS A 1 90  ? -19.93291 -50.77969 4.85836   1.000 34.64875  ? 90  LYS A O    1 
ATOM   1374 C CB   . LYS A 1 90  ? -22.68095 -50.53079 6.24972   1.000 32.07105  ? 90  LYS A CB   1 
ATOM   1375 C CG   . LYS A 1 90  ? -22.72077 -51.92028 6.94534   1.000 40.54863  ? 90  LYS A CG   1 
ATOM   1376 C CD   . LYS A 1 90  ? -22.89612 -51.87067 8.44313   1.000 56.59729  ? 90  LYS A CD   1 
ATOM   1377 C CE   . LYS A 1 90  ? -23.96353 -52.85979 8.90108   1.000 66.35029  ? 90  LYS A CE   1 
ATOM   1378 N NZ   . LYS A 1 90  ? -24.06517 -52.91009 10.39415  1.000 61.16182  ? 90  LYS A NZ   1 
ATOM   1379 H H    . LYS A 1 90  ? -21.90225 -48.60327 4.92032   1.000 42.98401  ? 90  LYS A H    1 
ATOM   1380 H HA   . LYS A 1 90  ? -21.33051 -49.51448 7.37758   1.000 38.15616  ? 90  LYS A HA   1 
ATOM   1381 H HB2  . LYS A 1 90  ? -23.41167 -50.00496 6.61090   1.000 38.53936  ? 90  LYS A HB2  1 
ATOM   1382 H HB3  . LYS A 1 90  ? -22.81573 -50.67807 5.30049   1.000 38.53936  ? 90  LYS A HB3  1 
ATOM   1383 H HG2  . LYS A 1 90  ? -23.46389 -52.42671 6.58175   1.000 48.71246  ? 90  LYS A HG2  1 
ATOM   1384 H HG3  . LYS A 1 90  ? -21.88601 -52.38021 6.76494   1.000 48.71246  ? 90  LYS A HG3  1 
ATOM   1385 H HD2  . LYS A 1 90  ? -22.05849 -52.10128 8.87451   1.000 67.97085  ? 90  LYS A HD2  1 
ATOM   1386 H HD3  . LYS A 1 90  ? -23.17067 -50.97858 8.70712   1.000 67.97085  ? 90  LYS A HD3  1 
ATOM   1387 H HE2  . LYS A 1 90  ? -24.82477 -52.58922 8.54620   1.000 79.67444  ? 90  LYS A HE2  1 
ATOM   1388 H HE3  . LYS A 1 90  ? -23.73683 -53.74704 8.58125   1.000 79.67444  ? 90  LYS A HE3  1 
ATOM   1389 H HZ1  . LYS A 1 90  ? -23.89676 -52.10663 10.73796  1.000 73.44828  ? 90  LYS A HZ1  1 
ATOM   1390 H HZ2  . LYS A 1 90  ? -24.88418 -53.16151 10.63520  1.000 73.44828  ? 90  LYS A HZ2  1 
ATOM   1391 H HZ3  . LYS A 1 90  ? -23.47655 -53.49279 10.71987  1.000 73.44828  ? 90  LYS A HZ3  1 
ATOM   1392 N N    . VAL A 1 91  ? -19.38210 -50.99371 7.02881   1.000 35.23755  ? 91  VAL A N    1 
ATOM   1393 C CA   . VAL A 1 91  ? -18.20516 -51.81773 6.79562   1.000 35.15327  ? 91  VAL A CA   1 
ATOM   1394 C C    . VAL A 1 91  ? -18.43090 -53.15562 7.50063   1.000 38.24940  ? 91  VAL A C    1 
ATOM   1395 O O    . VAL A 1 91  ? -19.39315 -53.32920 8.24644   1.000 37.77296  ? 91  VAL A O    1 
ATOM   1396 C CB   . VAL A 1 91  ? -16.90626 -51.13019 7.24084   1.000 33.61428  ? 91  VAL A CB   1 
ATOM   1397 C CG1  . VAL A 1 91  ? -16.62199 -49.91525 6.34600   1.000 36.43359  ? 91  VAL A CG1  1 
ATOM   1398 C CG2  . VAL A 1 91  ? -16.95937 -50.68520 8.70033   1.000 39.11744  ? 91  VAL A CG2  1 
ATOM   1399 H H    . VAL A 1 91  ? -19.51171 -50.80719 7.85828   1.000 42.33916  ? 91  VAL A H    1 
ATOM   1400 H HA   . VAL A 1 91  ? -18.10730 -51.99679 5.84732   1.000 42.23802  ? 91  VAL A HA   1 
ATOM   1401 H HB   . VAL A 1 91  ? -16.18831 -51.77713 7.15765   1.000 40.39124  ? 91  VAL A HB   1 
ATOM   1402 H HG11 . VAL A 1 91  ? -15.77003 -49.52780 6.60082   1.000 43.77441  ? 91  VAL A HG11 1 
ATOM   1403 H HG12 . VAL A 1 91  ? -16.59012 -50.20500 5.42084   1.000 43.77441  ? 91  VAL A HG12 1 
ATOM   1404 H HG13 . VAL A 1 91  ? -17.33044 -49.26331 6.46422   1.000 43.77441  ? 91  VAL A HG13 1 
ATOM   1405 H HG21 . VAL A 1 91  ? -17.88102 -50.70205 9.00228   1.000 46.99503  ? 91  VAL A HG21 1 
ATOM   1406 H HG22 . VAL A 1 91  ? -16.42485 -51.29262 9.23533   1.000 46.99503  ? 91  VAL A HG22 1 
ATOM   1407 H HG23 . VAL A 1 91  ? -16.60519 -49.78479 8.76904   1.000 46.99503  ? 91  VAL A HG23 1 
ATOM   1408 N N    . ASP A 1 92  ? -17.56996 -54.13693 7.19242   1.000 41.09288  ? 92  ASP A N    1 
ATOM   1409 C CA   . ASP A 1 92  ? -17.76168 -55.49384 7.70657   1.000 43.27906  ? 92  ASP A CA   1 
ATOM   1410 C C    . ASP A 1 92  ? -17.05288 -55.74869 9.03356   1.000 48.67935  ? 92  ASP A C    1 
ATOM   1411 O O    . ASP A 1 92  ? -17.15746 -56.85264 9.58304   1.000 42.75159  ? 92  ASP A O    1 
ATOM   1412 C CB   . ASP A 1 92  ? -17.28496 -56.54009 6.66913   1.000 45.97104  ? 92  ASP A CB   1 
ATOM   1413 C CG   . ASP A 1 92  ? -15.77668 -56.51926 6.44485   1.000 53.02393  ? 92  ASP A CG   1 
ATOM   1414 O OD1  . ASP A 1 92  ? -15.08211 -55.66110 7.01182   1.000 51.81619  ? 92  ASP A OD1  1 
ATOM   1415 O OD2  . ASP A 1 92  ? -15.27830 -57.38102 5.68639   1.000 59.76521  ? 92  ASP A OD2  1 
ATOM   1416 H H    . ASP A 1 92  ? -16.87677 -54.03857 6.69301   1.000 49.36556  ? 92  ASP A H    1 
ATOM   1417 H HA   . ASP A 1 92  ? -18.71253 -55.62192 7.84932   1.000 51.98897  ? 92  ASP A HA   1 
ATOM   1418 H HB2  . ASP A 1 92  ? -17.52770 -57.42578 6.98144   1.000 55.21935  ? 92  ASP A HB2  1 
ATOM   1419 H HB3  . ASP A 1 92  ? -17.71529 -56.35859 5.81897   1.000 55.21935  ? 92  ASP A HB3  1 
ATOM   1420 N N    . THR A 1 93  ? -16.34259 -54.76213 9.56077   1.000 44.56445  ? 93  THR A N    1 
ATOM   1421 C CA   . THR A 1 93  ? -15.56186 -54.89344 10.78042  1.000 34.98802  ? 93  THR A CA   1 
ATOM   1422 C C    . THR A 1 93  ? -15.96422 -53.75174 11.69920  1.000 43.27953  ? 93  THR A C    1 
ATOM   1423 O O    . THR A 1 93  ? -15.89994 -52.58748 11.29287  1.000 42.42605  ? 93  THR A O    1 
ATOM   1424 C CB   . THR A 1 93  ? -14.05954 -54.81437 10.46943  1.000 39.83300  ? 93  THR A CB   1 
ATOM   1425 O OG1  . THR A 1 93  ? -13.69181 -55.92018 9.62956   1.000 48.91772  ? 93  THR A OG1  1 
ATOM   1426 C CG2  . THR A 1 93  ? -13.22071 -54.82705 11.74159  1.000 43.32550  ? 93  THR A CG2  1 
ATOM   1427 H H    . THR A 1 93  ? -16.29551 -53.97566 9.21603   1.000 53.53144  ? 93  THR A H    1 
ATOM   1428 H HA   . THR A 1 93  ? -15.73874 -55.74051 11.21870  1.000 42.03973  ? 93  THR A HA   1 
ATOM   1429 H HB   . THR A 1 93  ? -13.87191 -53.97955 10.01252  1.000 47.85370  ? 93  THR A HB   1 
ATOM   1430 H HG1  . THR A 1 93  ? -13.73238 -56.63746 10.06482  1.000 58.75537  ? 93  THR A HG1  1 
ATOM   1431 H HG21 . THR A 1 93  ? -12.28794 -54.97813 11.52244  1.000 52.04470  ? 93  THR A HG21 1 
ATOM   1432 H HG22 . THR A 1 93  ? -13.30235 -53.97682 12.20130  1.000 52.04470  ? 93  THR A HG22 1 
ATOM   1433 H HG23 . THR A 1 93  ? -13.52397 -55.53449 12.33190  1.000 52.04470  ? 93  THR A HG23 1 
ATOM   1434 N N    . ALA A 1 94  ? -16.38312 -54.07899 12.91936  1.000 35.11612  ? 94  ALA A N    1 
ATOM   1435 C CA   . ALA A 1 94  ? -16.61500 -53.05916 13.93115  1.000 37.15095  ? 94  ALA A CA   1 
ATOM   1436 C C    . ALA A 1 94  ? -15.27453 -52.51183 14.40884  1.000 41.54990  ? 94  ALA A C    1 
ATOM   1437 O O    . ALA A 1 94  ? -14.29283 -53.24593 14.52683  1.000 39.55911  ? 94  ALA A O    1 
ATOM   1438 C CB   . ALA A 1 94  ? -17.40355 -53.63258 15.10380  1.000 42.42849  ? 94  ALA A CB   1 
ATOM   1439 H H    . ALA A 1 94  ? -16.53939 -54.88230 13.18371  1.000 42.19345  ? 94  ALA A H    1 
ATOM   1440 H HA   . ALA A 1 94  ? -17.13985 -52.33334 13.55883  1.000 44.63524  ? 94  ALA A HA   1 
ATOM   1441 H HB1  . ALA A 1 94  ? -16.88707 -54.34381 15.51402  1.000 50.96829  ? 94  ALA A HB1  1 
ATOM   1442 H HB2  . ALA A 1 94  ? -17.56669 -52.92744 15.74960  1.000 50.96829  ? 94  ALA A HB2  1 
ATOM   1443 H HB3  . ALA A 1 94  ? -18.24678 -53.98271 14.77626  1.000 50.96829  ? 94  ALA A HB3  1 
ATOM   1444 N N    . ASN A 1 95  ? -15.21159 -51.20967 14.65034  1.000 39.83647  ? 95  ASN A N    1 
ATOM   1445 C CA   . ASN A 1 95  ? -13.94274 -50.61696 15.07889  1.000 30.98216  ? 95  ASN A CA   1 
ATOM   1446 C C    . ASN A 1 95  ? -13.62128 -51.15533 16.46543  1.000 30.03715  ? 95  ASN A C    1 
ATOM   1447 O O    . ASN A 1 95  ? -14.38315 -50.90383 17.40653  1.000 35.60501  ? 95  ASN A O    1 
ATOM   1448 C CB   . ASN A 1 95  ? -14.04417 -49.07526 15.10450  1.000 32.38200  ? 95  ASN A CB   1 
ATOM   1449 C CG   . ASN A 1 95  ? -12.71620 -48.37865 15.45089  1.000 36.11150  ? 95  ASN A CG   1 
ATOM   1450 O OD1  . ASN A 1 95  ? -11.72411 -48.99974 15.81246  1.000 35.05722  ? 95  ASN A OD1  1 
ATOM   1451 N ND2  . ASN A 1 95  ? -12.70339 -47.04646 15.31038  1.000 33.24213  ? 95  ASN A ND2  1 
ATOM   1452 H H    . ASN A 1 95  ? -15.86811 -50.65902 14.57696  1.000 47.85787  ? 95  ASN A H    1 
ATOM   1453 H HA   . ASN A 1 95  ? -13.23196 -50.84768 14.46047  1.000 37.23270  ? 95  ASN A HA   1 
ATOM   1454 H HB2  . ASN A 1 95  ? -14.32240 -48.76504 14.22858  1.000 38.91250  ? 95  ASN A HB2  1 
ATOM   1455 H HB3  . ASN A 1 95  ? -14.69850 -48.81542 15.77176  1.000 38.91250  ? 95  ASN A HB3  1 
ATOM   1456 H HD21 . ASN A 1 95  ? -11.98912 -46.60208 15.48913  1.000 39.94465  ? 95  ASN A HD21 1 
ATOM   1457 H HD22 . ASN A 1 95  ? -13.40942 -46.63563 15.04144  1.000 39.94465  ? 95  ASN A HD22 1 
ATOM   1458 N N    . PRO A 1 96  ? -12.50570 -51.86705 16.65417  1.000 34.94988  ? 96  PRO A N    1 
ATOM   1459 C CA   . PRO A 1 96  ? -12.21302 -52.42048 17.98987  1.000 37.16204  ? 96  PRO A CA   1 
ATOM   1460 C C    . PRO A 1 96  ? -11.90274 -51.35732 19.01841  1.000 39.87051  ? 96  PRO A C    1 
ATOM   1461 O O    . PRO A 1 96  ? -11.97763 -51.62819 20.22557  1.000 36.39130  ? 96  PRO A O    1 
ATOM   1462 C CB   . PRO A 1 96  ? -11.00104 -53.33159 17.73689  1.000 36.95764  ? 96  PRO A CB   1 
ATOM   1463 C CG   . PRO A 1 96  ? -10.31716 -52.74238 16.54969  1.000 42.01071  ? 96  PRO A CG   1 
ATOM   1464 C CD   . PRO A 1 96  ? -11.41490 -52.10987 15.68761  1.000 36.08917  ? 96  PRO A CD   1 
ATOM   1465 H HA   . PRO A 1 96  ? -12.95418 -52.96285 18.30199  1.000 44.64854  ? 96  PRO A HA   1 
ATOM   1466 H HB2  . PRO A 1 96  ? -10.41724 -53.32727 18.51153  1.000 44.40327  ? 96  PRO A HB2  1 
ATOM   1467 H HB3  . PRO A 1 96  ? -11.30033 -54.23556 17.55205  1.000 44.40327  ? 96  PRO A HB3  1 
ATOM   1468 H HG2  . PRO A 1 96  ? -9.68189  -52.06983 16.84126  1.000 50.46696  ? 96  PRO A HG2  1 
ATOM   1469 H HG3  . PRO A 1 96  ? -9.85800  -53.44181 16.05890  1.000 50.46696  ? 96  PRO A HG3  1 
ATOM   1470 H HD2  . PRO A 1 96  ? -11.10924 -51.27712 15.29519  1.000 43.36111  ? 96  PRO A HD2  1 
ATOM   1471 H HD3  . PRO A 1 96  ? -11.70093 -52.72008 14.98994  1.000 43.36111  ? 96  PRO A HD3  1 
ATOM   1472 N N    . LYS A 1 97  ? -11.59537 -50.14326 18.56329  1.000 39.49847  ? 97  LYS A N    1 
ATOM   1473 C CA   . LYS A 1 97  ? -11.26179 -49.01488 19.41107  1.000 37.97491  ? 97  LYS A CA   1 
ATOM   1474 C C    . LYS A 1 97  ? -12.43556 -48.08061 19.64085  1.000 37.90236  ? 97  LYS A C    1 
ATOM   1475 O O    . LYS A 1 97  ? -12.24340 -46.99236 20.18713  1.000 42.74102  ? 97  LYS A O    1 
ATOM   1476 C CB   . LYS A 1 97  ? -10.12251 -48.22082 18.78905  1.000 36.26688  ? 97  LYS A CB   1 
ATOM   1477 C CG   . LYS A 1 97  ? -8.83988  -49.01984 18.62406  1.000 46.42671  ? 97  LYS A CG   1 
ATOM   1478 C CD   . LYS A 1 97  ? -7.73406  -48.12512 18.05705  1.000 44.65385  ? 97  LYS A CD   1 
ATOM   1479 C CE   . LYS A 1 97  ? -6.48303  -48.91568 17.69963  1.000 51.13560  ? 97  LYS A CE   1 
ATOM   1480 N NZ   . LYS A 1 97  ? -5.53399  -48.05689 16.95165  1.000 56.63310  ? 97  LYS A NZ   1 
ATOM   1481 H H    . LYS A 1 97  ? -11.57399 -49.94528 17.72667  1.000 47.45226  ? 97  LYS A H    1 
ATOM   1482 H HA   . LYS A 1 97  ? -10.97558 -49.36137 20.27068  1.000 45.62399  ? 97  LYS A HA   1 
ATOM   1483 H HB2  . LYS A 1 97  ? -10.39756 -47.91688 17.90992  1.000 43.57435  ? 97  LYS A HB2  1 
ATOM   1484 H HB3  . LYS A 1 97  ? -9.92639  -47.45934 19.35701  1.000 43.57435  ? 97  LYS A HB3  1 
ATOM   1485 H HG2  . LYS A 1 97  ? -8.55340  -49.35993 19.48614  1.000 55.76616  ? 97  LYS A HG2  1 
ATOM   1486 H HG3  . LYS A 1 97  ? -8.98986  -49.75581 18.01027  1.000 55.76616  ? 97  LYS A HG3  1 
ATOM   1487 H HD2  . LYS A 1 97  ? -8.05693  -47.69039 17.25228  1.000 53.63872  ? 97  LYS A HD2  1 
ATOM   1488 H HD3  . LYS A 1 97  ? -7.49170  -47.45921 18.71941  1.000 53.63872  ? 97  LYS A HD3  1 
ATOM   1489 H HE2  . LYS A 1 97  ? -6.04967  -49.22510 18.51041  1.000 61.41682  ? 97  LYS A HE2  1 
ATOM   1490 H HE3  . LYS A 1 97  ? -6.72319  -49.67239 17.14230  1.000 61.41682  ? 97  LYS A HE3  1 
ATOM   1491 H HZ1  . LYS A 1 97  ? -4.78980  -48.51062 16.77162  1.000 68.01382  ? 97  LYS A HZ1  1 
ATOM   1492 H HZ2  . LYS A 1 97  ? -5.90236  -47.79089 16.18637  1.000 68.01382  ? 97  LYS A HZ2  1 
ATOM   1493 H HZ3  . LYS A 1 97  ? -5.32520  -47.34014 17.43619  1.000 68.01382  ? 97  LYS A HZ3  1 
ATOM   1494 N N    . THR A 1 98  ? -13.63403 -48.46248 19.22586  1.000 36.34567  ? 98  THR A N    1 
ATOM   1495 C CA   . THR A 1 98  ? -14.79464 -47.61335 19.44981  1.000 32.74139  ? 98  THR A CA   1 
ATOM   1496 C C    . THR A 1 98  ? -14.89439 -47.24279 20.92195  1.000 38.60453  ? 98  THR A C    1 
ATOM   1497 O O    . THR A 1 98  ? -15.02308 -48.13795 21.79220  1.000 35.38678  ? 98  THR A O    1 
ATOM   1498 C CB   . THR A 1 98  ? -16.07559 -48.29626 18.97135  1.000 33.49207  ? 98  THR A CB   1 
ATOM   1499 O OG1  . THR A 1 98  ? -15.90425 -48.69287 17.60474  1.000 36.84382  ? 98  THR A OG1  1 
ATOM   1500 C CG2  . THR A 1 98  ? -17.27533 -47.35764 19.03971  1.000 36.69043  ? 98  THR A CG2  1 
ATOM   1501 H H    . THR A 1 98  ? -13.80021 -49.20040 18.81664  1.000 43.66890  ? 98  THR A H    1 
ATOM   1502 H HA   . THR A 1 98  ? -14.69656 -46.79869 18.93250  1.000 39.34377  ? 98  THR A HA   1 
ATOM   1503 H HB   . THR A 1 98  ? -16.25341 -49.06026 19.54195  1.000 40.24458  ? 98  THR A HB   1 
ATOM   1504 H HG1  . THR A 1 98  ? -15.87566 -48.01451 17.11014  1.000 44.26668  ? 98  THR A HG1  1 
ATOM   1505 H HG21 . THR A 1 98  ? -18.09804 -47.87129 19.05363  1.000 44.08262  ? 98  THR A HG21 1 
ATOM   1506 H HG22 . THR A 1 98  ? -17.22815 -46.81694 19.84366  1.000 44.08262  ? 98  THR A HG22 1 
ATOM   1507 H HG23 . THR A 1 98  ? -17.28288 -46.77202 18.26648  1.000 44.08262  ? 98  THR A HG23 1 
ATOM   1508 N N    . PRO A 1 99  ? -14.85270 -45.96393 21.25967  1.000 39.81061  ? 99  PRO A N    1 
ATOM   1509 C CA   . PRO A 1 99  ? -15.09656 -45.54333 22.63750  1.000 38.33659  ? 99  PRO A CA   1 
ATOM   1510 C C    . PRO A 1 99  ? -16.58683 -45.56637 22.93175  1.000 38.52169  ? 99  PRO A C    1 
ATOM   1511 O O    . PRO A 1 99  ? -17.41884 -45.66597 22.03834  1.000 39.92790  ? 99  PRO A O    1 
ATOM   1512 C CB   . PRO A 1 99  ? -14.53955 -44.11235 22.66735  1.000 36.60421  ? 99  PRO A CB   1 
ATOM   1513 C CG   . PRO A 1 99  ? -14.90037 -43.59109 21.25920  1.000 40.08148  ? 99  PRO A CG   1 
ATOM   1514 C CD   . PRO A 1 99  ? -14.74161 -44.81584 20.33201  1.000 36.05485  ? 99  PRO A CD   1 
ATOM   1515 H HA   . PRO A 1 99  ? -14.61640 -46.08932 23.27956  1.000 46.05801  ? 99  PRO A HA   1 
ATOM   1516 H HB2  . PRO A 1 99  ? -14.97225 -43.59218 23.36240  1.000 43.97916  ? 99  PRO A HB2  1 
ATOM   1517 H HB3  . PRO A 1 99  ? -13.58005 -44.12256 22.80932  1.000 43.97916  ? 99  PRO A HB3  1 
ATOM   1518 H HG2  . PRO A 1 99  ? -15.81389 -43.26505 21.25059  1.000 48.15187  ? 99  PRO A HG2  1 
ATOM   1519 H HG3  . PRO A 1 99  ? -14.29201 -42.88034 21.00302  1.000 48.15187  ? 99  PRO A HG3  1 
ATOM   1520 H HD2  . PRO A 1 99  ? -15.44805 -44.83948 19.66772  1.000 43.31992  ? 99  PRO A HD2  1 
ATOM   1521 H HD3  . PRO A 1 99  ? -13.87557 -44.80784 19.89518  1.000 43.31992  ? 99  PRO A HD3  1 
ATOM   1522 N N    . LYS A 1 100 ? -16.92507 -45.44733 24.21693  1.000 36.03502  ? 100 LYS A N    1 
ATOM   1523 C CA   . LYS A 1 100 ? -18.28469 -45.05970 24.54576  1.000 35.83953  ? 100 LYS A CA   1 
ATOM   1524 C C    . LYS A 1 100 ? -18.52255 -43.69354 23.92123  1.000 34.07877  ? 100 LYS A C    1 
ATOM   1525 O O    . LYS A 1 100 ? -17.68796 -42.79530 24.07068  1.000 37.70094  ? 100 LYS A O    1 
ATOM   1526 C CB   . LYS A 1 100 ? -18.50164 -44.97332 26.05667  1.000 42.65935  ? 100 LYS A CB   1 
ATOM   1527 C CG   . LYS A 1 100 ? -18.15811 -46.22434 26.82441  1.000 62.38129  ? 100 LYS A CG   1 
ATOM   1528 C CD   . LYS A 1 100 ? -18.66759 -46.06668 28.24357  1.000 70.99495  ? 100 LYS A CD   1 
ATOM   1529 C CE   . LYS A 1 100 ? -18.05132 -47.07305 29.18644  1.000 76.42144  ? 100 LYS A CE   1 
ATOM   1530 N NZ   . LYS A 1 100 ? -18.68353 -46.98514 30.53847  1.000 77.74366  ? 100 LYS A NZ   1 
ATOM   1531 H H    . LYS A 1 100 ? -16.40251 -45.58135 24.88669  1.000 43.29613  ? 100 LYS A H    1 
ATOM   1532 H HA   . LYS A 1 100 ? -18.91080 -45.72177 24.21329  1.000 43.06153  ? 100 LYS A HA   1 
ATOM   1533 H HB2  . LYS A 1 100 ? -17.94801 -44.25727 26.40548  1.000 51.24532  ? 100 LYS A HB2  1 
ATOM   1534 H HB3  . LYS A 1 100 ? -19.43765 -44.77929 26.22142  1.000 51.24532  ? 100 LYS A HB3  1 
ATOM   1535 H HG2  . LYS A 1 100 ? -18.58535 -46.99376 26.41654  1.000 74.91164  ? 100 LYS A HG2  1 
ATOM   1536 H HG3  . LYS A 1 100 ? -17.19651 -46.35026 26.84366  1.000 74.91164  ? 100 LYS A HG3  1 
ATOM   1537 H HD2  . LYS A 1 100 ? -18.44727 -45.17816 28.56433  1.000 85.24805  ? 100 LYS A HD2  1 
ATOM   1538 H HD3  . LYS A 1 100 ? -19.62919 -46.19377 28.25284  1.000 85.24805  ? 100 LYS A HD3  1 
ATOM   1539 H HE2  . LYS A 1 100 ? -18.18796 -47.96853 28.83954  1.000 91.75983  ? 100 LYS A HE2  1 
ATOM   1540 H HE3  . LYS A 1 100 ? -17.10239 -46.89365 29.27727  1.000 91.75983  ? 100 LYS A HE3  1 
ATOM   1541 H HZ1  . LYS A 1 100 ? -19.56987 -47.01181 30.46237  1.000 93.34650  ? 100 LYS A HZ1  1 
ATOM   1542 H HZ2  . LYS A 1 100 ? -18.41643 -47.66696 31.04431  1.000 93.34650  ? 100 LYS A HZ2  1 
ATOM   1543 H HZ3  . LYS A 1 100 ? -18.45044 -46.22297 30.93453  1.000 93.34650  ? 100 LYS A HZ3  1 
ATOM   1544 N N    . TYR A 1 101 ? -19.66014 -43.52182 23.24960  1.000 36.76693  ? 101 TYR A N    1 
ATOM   1545 C CA   . TYR A 1 101 ? -19.90439 -42.26983 22.55212  1.000 37.27949  ? 101 TYR A CA   1 
ATOM   1546 C C    . TYR A 1 101 ? -21.38885 -42.01773 22.37949  1.000 41.04064  ? 101 TYR A C    1 
ATOM   1547 O O    . TYR A 1 101 ? -22.22071 -42.92150 22.47803  1.000 33.08009  ? 101 TYR A O    1 
ATOM   1548 C CB   . TYR A 1 101 ? -19.24411 -42.24857 21.14382  1.000 31.24764  ? 101 TYR A CB   1 
ATOM   1549 C CG   . TYR A 1 101 ? -19.96865 -43.13813 20.11918  1.000 37.92249  ? 101 TYR A CG   1 
ATOM   1550 C CD1  . TYR A 1 101 ? -19.68977 -44.50626 20.01289  1.000 39.95812  ? 101 TYR A CD1  1 
ATOM   1551 C CD2  . TYR A 1 101 ? -20.94914 -42.61020 19.27858  1.000 39.40194  ? 101 TYR A CD2  1 
ATOM   1552 C CE1  . TYR A 1 101 ? -20.35910 -45.29991 19.10359  1.000 41.42232  ? 101 TYR A CE1  1 
ATOM   1553 C CE2  . TYR A 1 101 ? -21.63256 -43.40944 18.38233  1.000 40.00447  ? 101 TYR A CE2  1 
ATOM   1554 C CZ   . TYR A 1 101 ? -21.32182 -44.73515 18.28168  1.000 40.55565  ? 101 TYR A CZ   1 
ATOM   1555 O OH   . TYR A 1 101 ? -21.99821 -45.50120 17.35560  1.000 41.63737  ? 101 TYR A OH   1 
ATOM   1556 H H    . TYR A 1 101 ? -20.28952 -44.10450 23.18657  1.000 44.17442  ? 101 TYR A H    1 
ATOM   1557 H HA   . TYR A 1 101 ? -19.53549 -41.56573 23.10806  1.000 44.78949  ? 101 TYR A HA   1 
ATOM   1558 H HB2  . TYR A 1 101 ? -19.25217 -41.33886 20.80728  1.000 37.55127  ? 101 TYR A HB2  1 
ATOM   1559 H HB3  . TYR A 1 101 ? -18.33067 -42.56574 21.22081  1.000 37.55127  ? 101 TYR A HB3  1 
ATOM   1560 H HD1  . TYR A 1 101 ? -19.04359 -44.88593 20.56352  1.000 48.00385  ? 101 TYR A HD1  1 
ATOM   1561 H HD2  . TYR A 1 101 ? -21.14659 -41.70246 19.32238  1.000 47.33643  ? 101 TYR A HD2  1 
ATOM   1562 H HE1  . TYR A 1 101 ? -20.16552 -46.20750 19.04271  1.000 49.76088  ? 101 TYR A HE1  1 
ATOM   1563 H HE2  . TYR A 1 101 ? -22.30214 -43.04553 17.84929  1.000 48.05946  ? 101 TYR A HE2  1 
ATOM   1564 H HH   . TYR A 1 101 ? -21.71871 -46.29300 17.37858  1.000 50.01895  ? 101 TYR A HH   1 
ATOM   1565 N N    . LYS A 1 102 ? -21.69743 -40.75470 22.08607  1.000 32.64293  ? 102 LYS A N    1 
ATOM   1566 C CA   . LYS A 1 102 ? -23.02715 -40.31871 21.68596  1.000 33.97097  ? 102 LYS A CA   1 
ATOM   1567 C C    . LYS A 1 102 ? -22.83600 -39.19568 20.66016  1.000 31.63165  ? 102 LYS A C    1 
ATOM   1568 O O    . LYS A 1 102 ? -21.74624 -38.63128 20.52896  1.000 32.54149  ? 102 LYS A O    1 
ATOM   1569 C CB   . LYS A 1 102 ? -23.86885 -39.86330 22.88510  1.000 43.62488  ? 102 LYS A CB   1 
ATOM   1570 C CG   . LYS A 1 102 ? -23.28217 -38.72898 23.69959  1.000 44.23779  ? 102 LYS A CG   1 
ATOM   1571 C CD   . LYS A 1 102 ? -24.22592 -38.31128 24.86367  1.000 48.89372  ? 102 LYS A CD   1 
ATOM   1572 C CE   . LYS A 1 102 ? -24.40142 -39.41401 25.90347  1.000 64.72502  ? 102 LYS A CE   1 
ATOM   1573 N NZ   . LYS A 1 102 ? -25.33054 -39.01924 27.01631  1.000 74.70698  ? 102 LYS A NZ   1 
ATOM   1574 H H    . LYS A 1 102 ? -21.12998 -40.10905 22.11324  1.000 39.22562  ? 102 LYS A H    1 
ATOM   1575 H HA   . LYS A 1 102 ? -23.51931 -41.04358 21.26975  1.000 40.81927  ? 102 LYS A HA   1 
ATOM   1576 H HB2  . LYS A 1 102 ? -24.73213 -39.56677 22.55690  1.000 52.40396  ? 102 LYS A HB2  1 
ATOM   1577 H HB3  . LYS A 1 102 ? -23.98277 -40.61897 23.48250  1.000 52.40396  ? 102 LYS A HB3  1 
ATOM   1578 H HG2  . LYS A 1 102 ? -22.43596 -39.01161 24.08032  1.000 53.13945  ? 102 LYS A HG2  1 
ATOM   1579 H HG3  . LYS A 1 102 ? -23.14705 -37.95854 23.12595  1.000 53.13945  ? 102 LYS A HG3  1 
ATOM   1580 H HD2  . LYS A 1 102 ? -23.85373 -37.53470 25.31010  1.000 58.72656  ? 102 LYS A HD2  1 
ATOM   1581 H HD3  . LYS A 1 102 ? -25.10036 -38.09853 24.50174  1.000 58.72656  ? 102 LYS A HD3  1 
ATOM   1582 H HE2  . LYS A 1 102 ? -24.76842 -40.20105 25.47130  1.000 77.72413  ? 102 LYS A HE2  1 
ATOM   1583 H HE3  . LYS A 1 102 ? -23.53784 -39.62185 26.29326  1.000 77.72413  ? 102 LYS A HE3  1 
ATOM   1584 H HZ1  . LYS A 1 102 ? -25.36281 -39.66392 27.62904  1.000 89.70248  ? 102 LYS A HZ1  1 
ATOM   1585 H HZ2  . LYS A 1 102 ? -25.04381 -38.26949 27.40071  1.000 89.70248  ? 102 LYS A HZ2  1 
ATOM   1586 H HZ3  . LYS A 1 102 ? -26.14969 -38.88437 26.69553  1.000 89.70248  ? 102 LYS A HZ3  1 
ATOM   1587 N N    . PHE A 1 103 ? -23.88888 -38.92055 19.91085  1.000 31.23012  ? 103 PHE A N    1 
ATOM   1588 C CA   . PHE A 1 103 ? -23.92670 -37.79856 18.98698  1.000 30.50222  ? 103 PHE A CA   1 
ATOM   1589 C C    . PHE A 1 103 ? -24.75724 -36.71297 19.64865  1.000 34.26925  ? 103 PHE A C    1 
ATOM   1590 O O    . PHE A 1 103 ? -25.85392 -36.99719 20.14578  1.000 37.61393  ? 103 PHE A O    1 
ATOM   1591 C CB   . PHE A 1 103 ? -24.57122 -38.16273 17.64802  1.000 30.17806  ? 103 PHE A CB   1 
ATOM   1592 C CG   . PHE A 1 103 ? -23.74852 -39.08937 16.78875  1.000 29.11143  ? 103 PHE A CG   1 
ATOM   1593 C CD1  . PHE A 1 103 ? -22.41600 -39.34320 17.06664  1.000 26.33269  ? 103 PHE A CD1  1 
ATOM   1594 C CD2  . PHE A 1 103 ? -24.33152 -39.70386 15.68963  1.000 31.33031  ? 103 PHE A CD2  1 
ATOM   1595 C CE1  . PHE A 1 103 ? -21.67936 -40.16637 16.29100  1.000 32.69293  ? 103 PHE A CE1  1 
ATOM   1596 C CE2  . PHE A 1 103 ? -23.59317 -40.55872 14.89356  1.000 34.37066  ? 103 PHE A CE2  1 
ATOM   1597 C CZ   . PHE A 1 103 ? -22.26428 -40.79255 15.19015  1.000 32.51474  ? 103 PHE A CZ   1 
ATOM   1598 H H    . PHE A 1 103 ? -24.61483 -39.38156 19.91901  1.000 37.53025  ? 103 PHE A H    1 
ATOM   1599 H HA   . PHE A 1 103 ? -23.02328 -37.49891 18.80006  1.000 36.65677  ? 103 PHE A HA   1 
ATOM   1600 H HB2  . PHE A 1 103 ? -25.41904 -38.60062 17.82226  1.000 36.26777  ? 103 PHE A HB2  1 
ATOM   1601 H HB3  . PHE A 1 103 ? -24.71657 -37.34728 17.14323  1.000 36.26777  ? 103 PHE A HB3  1 
ATOM   1602 H HD1  . PHE A 1 103 ? -22.01988 -38.93762 17.80387  1.000 31.65333  ? 103 PHE A HD1  1 
ATOM   1603 H HD2  . PHE A 1 103 ? -25.22429 -39.53945 15.48758  1.000 37.65047  ? 103 PHE A HD2  1 
ATOM   1604 H HE1  . PHE A 1 103 ? -20.78332 -40.31585 16.49014  1.000 39.28562  ? 103 PHE A HE1  1 
ATOM   1605 H HE2  . PHE A 1 103 ? -23.98886 -40.97453 14.16183  1.000 41.29890  ? 103 PHE A HE2  1 
ATOM   1606 H HZ   . PHE A 1 103 ? -21.76127 -41.36555 14.65765  1.000 39.07179  ? 103 PHE A HZ   1 
ATOM   1607 N N    . VAL A 1 104 ? -24.26113 -35.48097 19.65855  1.000 30.14549  ? 104 VAL A N    1 
ATOM   1608 C CA   . VAL A 1 104 ? -25.02886 -34.40017 20.25725  1.000 36.14805  ? 104 VAL A CA   1 
ATOM   1609 C C    . VAL A 1 104 ? -24.98952 -33.17429 19.35468  1.000 37.09527  ? 104 VAL A C    1 
ATOM   1610 O O    . VAL A 1 104 ? -24.03038 -32.94607 18.60339  1.000 35.24675  ? 104 VAL A O    1 
ATOM   1611 C CB   . VAL A 1 104 ? -24.50688 -34.03769 21.66857  1.000 35.39382  ? 104 VAL A CB   1 
ATOM   1612 C CG1  . VAL A 1 104 ? -24.41085 -35.28715 22.58711  1.000 37.16951  ? 104 VAL A CG1  1 
ATOM   1613 C CG2  . VAL A 1 104 ? -23.20618 -33.29739 21.53902  1.000 37.99272  ? 104 VAL A CG2  1 
ATOM   1614 H H    . VAL A 1 104 ? -23.49902 -35.25324 19.33156  1.000 36.22869  ? 104 VAL A H    1 
ATOM   1615 H HA   . VAL A 1 104 ? -25.95286 -34.68719 20.32605  1.000 43.43177  ? 104 VAL A HA   1 
ATOM   1616 H HB   . VAL A 1 104 ? -25.13844 -33.45012 22.11219  1.000 42.52668  ? 104 VAL A HB   1 
ATOM   1617 H HG11 . VAL A 1 104 ? -24.09710 -35.01201 23.46276  1.000 44.65752  ? 104 VAL A HG11 1 
ATOM   1618 H HG12 . VAL A 1 104 ? -25.28914 -35.69189 22.66256  1.000 44.65752  ? 104 VAL A HG12 1 
ATOM   1619 H HG13 . VAL A 1 104 ? -23.78775 -35.91942 22.19610  1.000 44.65752  ? 104 VAL A HG13 1 
ATOM   1620 H HG21 . VAL A 1 104 ? -23.38896 -32.34710 21.47236  1.000 45.64537  ? 104 VAL A HG21 1 
ATOM   1621 H HG22 . VAL A 1 104 ? -22.66212 -33.47545 22.32209  1.000 45.64537  ? 104 VAL A HG22 1 
ATOM   1622 H HG23 . VAL A 1 104 ? -22.74716 -33.60273 20.74092  1.000 45.64537  ? 104 VAL A HG23 1 
ATOM   1623 N N    . ARG A 1 105 ? -26.03317 -32.37143 19.43635  1.000 34.12225  ? 105 ARG A N    1 
ATOM   1624 C CA   . ARG A 1 105 ? -26.07748 -31.11233 18.70387  1.000 34.64679  ? 105 ARG A CA   1 
ATOM   1625 C C    . ARG A 1 105 ? -25.82450 -30.00668 19.70997  1.000 37.40915  ? 105 ARG A C    1 
ATOM   1626 O O    . ARG A 1 105 ? -26.69033 -29.71244 20.53224  1.000 39.50815  ? 105 ARG A O    1 
ATOM   1627 C CB   . ARG A 1 105 ? -27.40322 -30.90210 17.99428  1.000 40.12575  ? 105 ARG A CB   1 
ATOM   1628 C CG   . ARG A 1 105 ? -27.30576 -29.77564 16.95674  1.000 35.77201  ? 105 ARG A CG   1 
ATOM   1629 C CD   . ARG A 1 105 ? -28.45708 -29.80417 16.01742  1.000 38.55999  ? 105 ARG A CD   1 
ATOM   1630 N NE   . ARG A 1 105 ? -28.49227 -28.56083 15.26921  1.000 38.58768  ? 105 ARG A NE   1 
ATOM   1631 C CZ   . ARG A 1 105 ? -27.96275 -28.39513 14.06695  1.000 39.35616  ? 105 ARG A CZ   1 
ATOM   1632 N NH1  . ARG A 1 105 ? -27.31464 -29.36892 13.46076  1.000 35.62985  ? 105 ARG A NH1  1 
ATOM   1633 N NH2  . ARG A 1 105 ? -28.09217 -27.22470 13.46127  1.000 35.11975  ? 105 ARG A NH2  1 
ATOM   1634 H H    . ARG A 1 105 ? -26.73266 -32.53134 19.91043  1.000 41.00080  ? 105 ARG A H    1 
ATOM   1635 H HA   . ARG A 1 105 ? -25.38721 -31.11357 18.02238  1.000 41.63025  ? 105 ARG A HA   1 
ATOM   1636 H HB2  . ARG A 1 105 ? -27.65629 -31.71929 17.53705  1.000 48.20501  ? 105 ARG A HB2  1 
ATOM   1637 H HB3  . ARG A 1 105 ? -28.08158 -30.66220 18.64480  1.000 48.20501  ? 105 ARG A HB3  1 
ATOM   1638 H HG2  . ARG A 1 105 ? -27.30347 -28.91872 17.41125  1.000 42.98052  ? 105 ARG A HG2  1 
ATOM   1639 H HG3  . ARG A 1 105 ? -26.48971 -29.88090 16.44305  1.000 42.98052  ? 105 ARG A HG3  1 
ATOM   1640 H HD2  . ARG A 1 105 ? -28.35806 -30.54268 15.39638  1.000 46.32608  ? 105 ARG A HD2  1 
ATOM   1641 H HD3  . ARG A 1 105 ? -29.28548 -29.89666 16.51350  1.000 46.32608  ? 105 ARG A HD3  1 
ATOM   1642 H HE   . ARG A 1 105 ? -28.88358 -27.88604 15.63133  1.000 46.35931  ? 105 ARG A HE   1 
ATOM   1643 H HH11 . ARG A 1 105 ? -27.22809 -30.13292 13.84602  1.000 42.80993  ? 105 ARG A HH11 1 
ATOM   1644 H HH12 . ARG A 1 105 ? -26.97814 -29.24058 12.67980  1.000 42.80993  ? 105 ARG A HH12 1 
ATOM   1645 H HH21 . ARG A 1 105 ? -28.51574 -26.58445 13.84891  1.000 42.19781  ? 105 ARG A HH21 1 
ATOM   1646 H HH22 . ARG A 1 105 ? -27.75265 -27.10482 12.68027  1.000 42.19781  ? 105 ARG A HH22 1 
ATOM   1647 N N    . ILE A 1 106 ? -24.63912 -29.39776 19.64030  1.000 34.11613  ? 106 ILE A N    1 
ATOM   1648 C CA   . ILE A 1 106 ? -24.30152 -28.38381 20.61969  1.000 36.54791  ? 106 ILE A CA   1 
ATOM   1649 C C    . ILE A 1 106 ? -25.08514 -27.10216 20.36223  1.000 37.06924  ? 106 ILE A C    1 
ATOM   1650 O O    . ILE A 1 106 ? -25.55286 -26.80430 19.25967  1.000 31.63577  ? 106 ILE A O    1 
ATOM   1651 C CB   . ILE A 1 106 ? -22.79407 -28.07039 20.65972  1.000 32.45302  ? 106 ILE A CB   1 
ATOM   1652 C CG1  . ILE A 1 106 ? -22.30506 -27.70716 19.27210  1.000 36.31707  ? 106 ILE A CG1  1 
ATOM   1653 C CG2  . ILE A 1 106 ? -22.03315 -29.12757 21.42101  1.000 50.44011  ? 106 ILE A CG2  1 
ATOM   1654 C CD1  . ILE A 1 106 ? -20.91800 -27.21152 19.30720  1.000 48.35327  ? 106 ILE A CD1  1 
ATOM   1655 H H    . ILE A 1 106 ? -24.03359 -29.55348 19.04980  1.000 40.99345  ? 106 ILE A H    1 
ATOM   1656 H HA   . ILE A 1 106 ? -24.55485 -28.74347 21.48420  1.000 43.91160  ? 106 ILE A HA   1 
ATOM   1657 H HB   . ILE A 1 106 ? -22.61577 -27.27326 21.18288  1.000 38.99773  ? 106 ILE A HB   1 
ATOM   1658 H HG12 . ILE A 1 106 ? -22.33552 -28.49317 18.70451  1.000 43.63459  ? 106 ILE A HG12 1 
ATOM   1659 H HG13 . ILE A 1 106 ? -22.87050 -27.01015 18.90419  1.000 43.63459  ? 106 ILE A HG13 1 
ATOM   1660 H HG21 . ILE A 1 106 ? -21.15902 -28.77936 21.65669  1.000 60.58223  ? 106 ILE A HG21 1 
ATOM   1661 H HG22 . ILE A 1 106 ? -22.52649 -29.35455 22.22475  1.000 60.58223  ? 106 ILE A HG22 1 
ATOM   1662 H HG23 . ILE A 1 106 ? -21.93612 -29.91265 20.85965  1.000 60.58223  ? 106 ILE A HG23 1 
ATOM   1663 H HD11 . ILE A 1 106 ? -20.78418 -26.70507 20.12359  1.000 58.07803  ? 106 ILE A HD11 1 
ATOM   1664 H HD12 . ILE A 1 106 ? -20.31157 -27.96824 19.28420  1.000 58.07803  ? 106 ILE A HD12 1 
ATOM   1665 H HD13 . ILE A 1 106 ? -20.76635 -26.64256 18.53637  1.000 58.07803  ? 106 ILE A HD13 1 
ATOM   1666 N N    . GLN A 1 107 ? -25.15667 -26.28792 21.39409  1.000 39.69033  ? 107 GLN A N    1 
ATOM   1667 C CA   . GLN A 1 107 ? -25.80975 -24.99653 21.29170  1.000 36.24534  ? 107 GLN A CA   1 
ATOM   1668 C C    . GLN A 1 107 ? -24.79400 -23.89784 21.00063  1.000 32.36008  ? 107 GLN A C    1 
ATOM   1669 O O    . GLN A 1 107 ? -23.61576 -24.01566 21.34570  1.000 31.61783  ? 107 GLN A O    1 
ATOM   1670 C CB   . GLN A 1 107 ? -26.56828 -24.69316 22.59403  1.000 37.81598  ? 107 GLN A CB   1 
ATOM   1671 C CG   . GLN A 1 107 ? -27.82657 -25.56819 22.78268  1.000 44.96684  ? 107 GLN A CG   1 
ATOM   1672 C CD   . GLN A 1 107 ? -28.97164 -25.20074 21.83350  1.000 51.54872  ? 107 GLN A CD   1 
ATOM   1673 O OE1  . GLN A 1 107 ? -29.49156 -24.08864 21.86819  1.000 55.05043  ? 107 GLN A OE1  1 
ATOM   1674 N NE2  . GLN A 1 107 ? -29.37489 -26.15026 20.99174  1.000 56.98966  ? 107 GLN A NE2  1 
ATOM   1675 H H    . GLN A 1 107 ? -24.83303 -26.45862 22.17237  1.000 47.68250  ? 107 GLN A H    1 
ATOM   1676 H HA   . GLN A 1 107 ? -26.45050 -24.99683 20.56346  1.000 43.54851  ? 107 GLN A HA   1 
ATOM   1677 H HB2  . GLN A 1 107 ? -25.97736 -24.85382 23.34629  1.000 45.43328  ? 107 GLN A HB2  1 
ATOM   1678 H HB3  . GLN A 1 107 ? -26.84889 -23.76468 22.58497  1.000 45.43328  ? 107 GLN A HB3  1 
ATOM   1679 H HG2  . GLN A 1 107 ? -27.59130 -26.49499 22.61966  1.000 54.01430  ? 107 GLN A HG2  1 
ATOM   1680 H HG3  . GLN A 1 107 ? -28.14854 -25.46257 23.69157  1.000 54.01430  ? 107 GLN A HG3  1 
ATOM   1681 H HE21 . GLN A 1 107 ? -28.99555 -26.92203 21.00043  1.000 68.44170  ? 107 GLN A HE21 1 
ATOM   1682 H HE22 . GLN A 1 107 ? -30.01470 -25.99180 20.43935  1.000 68.44170  ? 107 GLN A HE22 1 
ATOM   1683 N N    . PRO A 1 108 ? -25.18841 -22.82018 20.33159  1.000 35.92284  ? 108 PRO A N    1 
ATOM   1684 C CA   . PRO A 1 108 ? -24.25983 -21.68804 20.17490  1.000 36.06556  ? 108 PRO A CA   1 
ATOM   1685 C C    . PRO A 1 108 ? -23.78388 -21.19463 21.53770  1.000 34.79781  ? 108 PRO A C    1 
ATOM   1686 O O    . PRO A 1 108 ? -24.52410 -21.21522 22.52664  1.000 35.65046  ? 108 PRO A O    1 
ATOM   1687 C CB   . PRO A 1 108 ? -25.09083 -20.63744 19.41930  1.000 36.29632  ? 108 PRO A CB   1 
ATOM   1688 C CG   . PRO A 1 108 ? -26.52332 -21.00704 19.69492  1.000 40.71976  ? 108 PRO A CG   1 
ATOM   1689 C CD   . PRO A 1 108 ? -26.53296 -22.51692 19.80471  1.000 37.88162  ? 108 PRO A CD   1 
ATOM   1690 H HA   . PRO A 1 108 ? -23.49445 -21.92714 19.62908  1.000 43.33278  ? 108 PRO A HA   1 
ATOM   1691 H HB2  . PRO A 1 108 ? -24.88936 -19.75086 19.75738  1.000 43.60969  ? 108 PRO A HB2  1 
ATOM   1692 H HB3  . PRO A 1 108 ? -24.89667 -20.68254 18.47000  1.000 43.60969  ? 108 PRO A HB3  1 
ATOM   1693 H HG2  . PRO A 1 108 ? -26.81499 -20.59844 20.52491  1.000 48.91781  ? 108 PRO A HG2  1 
ATOM   1694 H HG3  . PRO A 1 108 ? -27.08663 -20.71027 18.96314  1.000 48.91781  ? 108 PRO A HG3  1 
ATOM   1695 H HD2  . PRO A 1 108 ? -27.22128 -22.81505 20.41972  1.000 45.51205  ? 108 PRO A HD2  1 
ATOM   1696 H HD3  . PRO A 1 108 ? -26.66477 -22.92653 18.93538  1.000 45.51205  ? 108 PRO A HD3  1 
ATOM   1697 N N    . GLY A 1 109 ? -22.49726 -20.89378 21.60250  1.000 28.13104  ? 109 GLY A N    1 
ATOM   1698 C CA   . GLY A 1 109 ? -21.80846 -20.45500 22.79663  1.000 30.42648  ? 109 GLY A CA   1 
ATOM   1699 C C    . GLY A 1 109 ? -21.09931 -21.55009 23.55736  1.000 39.14093  ? 109 GLY A C    1 
ATOM   1700 O O    . GLY A 1 109 ? -20.35119 -21.23875 24.48848  1.000 35.96265  ? 109 GLY A O    1 
ATOM   1701 H H    . GLY A 1 109 ? -21.97131 -20.93974 20.92363  1.000 33.81135  ? 109 GLY A H    1 
ATOM   1702 H HA2  . GLY A 1 109 ? -21.14652 -19.79116 22.54753  1.000 36.56588  ? 109 GLY A HA2  1 
ATOM   1703 H HA3  . GLY A 1 109 ? -22.45363 -20.04824 23.39596  1.000 36.56588  ? 109 GLY A HA3  1 
ATOM   1704 N N    . GLN A 1 110 ? -21.34270 -22.81496 23.22256  1.000 32.62977  ? 110 GLN A N    1 
ATOM   1705 C CA   . GLN A 1 110 ? -20.64641 -23.94293 23.81350  1.000 36.78329  ? 110 GLN A CA   1 
ATOM   1706 C C    . GLN A 1 110 ? -19.35234 -24.20252 23.06113  1.000 32.46671  ? 110 GLN A C    1 
ATOM   1707 O O    . GLN A 1 110 ? -19.16876 -23.75550 21.93388  1.000 27.35161  ? 110 GLN A O    1 
ATOM   1708 C CB   . GLN A 1 110 ? -21.53625 -25.18732 23.79087  1.000 34.74919  ? 110 GLN A CB   1 
ATOM   1709 C CG   . GLN A 1 110 ? -22.80243 -25.00803 24.59932  1.000 38.85393  ? 110 GLN A CG   1 
ATOM   1710 C CD   . GLN A 1 110 ? -22.48811 -24.67220 26.03921  1.000 55.22231  ? 110 GLN A CD   1 
ATOM   1711 O OE1  . GLN A 1 110 ? -22.74648 -23.55359 26.50531  1.000 53.63355  ? 110 GLN A OE1  1 
ATOM   1712 N NE2  . GLN A 1 110 ? -21.91076 -25.63206 26.75545  1.000 53.80305  ? 110 GLN A NE2  1 
ATOM   1713 H H    . GLN A 1 110 ? -21.92651 -23.04871 22.63593  1.000 39.20983  ? 110 GLN A H    1 
ATOM   1714 H HA   . GLN A 1 110 ? -20.42802 -23.75120 24.73894  1.000 44.19405  ? 110 GLN A HA   1 
ATOM   1715 H HB2  . GLN A 1 110 ? -21.78848 -25.37967 22.87420  1.000 41.75313  ? 110 GLN A HB2  1 
ATOM   1716 H HB3  . GLN A 1 110 ? -21.04399 -25.93549 24.16347  1.000 41.75313  ? 110 GLN A HB3  1 
ATOM   1717 H HG2  . GLN A 1 110 ? -23.32527 -24.28308 24.22252  1.000 46.67882  ? 110 GLN A HG2  1 
ATOM   1718 H HG3  . GLN A 1 110 ? -23.31533 -25.83114 24.58141  1.000 46.67882  ? 110 GLN A HG3  1 
ATOM   1719 H HE21 . GLN A 1 110 ? -21.73694 -26.39282 26.39402  1.000 64.61777  ? 110 GLN A HE21 1 
ATOM   1720 H HE22 . GLN A 1 110 ? -21.71112 -25.49218 27.58018  1.000 64.61777  ? 110 GLN A HE22 1 
ATOM   1721 N N    . THR A 1 111 ? -18.44346 -24.92786 23.70956  1.000 29.57158  ? 111 THR A N    1 
ATOM   1722 C CA   . THR A 1 111 ? -17.12476 -25.17709 23.16411  1.000 32.17473  ? 111 THR A CA   1 
ATOM   1723 C C    . THR A 1 111 ? -16.93776 -26.66260 22.95584  1.000 28.89361  ? 111 THR A C    1 
ATOM   1724 O O    . THR A 1 111 ? -17.70431 -27.50076 23.45978  1.000 29.65396  ? 111 THR A O    1 
ATOM   1725 C CB   . THR A 1 111 ? -16.04949 -24.61375 24.09124  1.000 30.93534  ? 111 THR A CB   1 
ATOM   1726 O OG1  . THR A 1 111 ? -16.21546 -25.16600 25.40465  1.000 33.13092  ? 111 THR A OG1  1 
ATOM   1727 C CG2  . THR A 1 111 ? -16.17502 -23.09116 24.12976  1.000 33.22510  ? 111 THR A CG2  1 
ATOM   1728 H H    . THR A 1 111 ? -18.57570 -25.28900 24.47878  1.000 35.54000  ? 111 THR A H    1 
ATOM   1729 H HA   . THR A 1 111 ? -17.02649 -24.74833 22.29958  1.000 38.66378  ? 111 THR A HA   1 
ATOM   1730 H HB   . THR A 1 111 ? -15.16167 -24.84321 23.77498  1.000 37.17651  ? 111 THR A HB   1 
ATOM   1731 H HG1  . THR A 1 111 ? -15.47772 -25.17921 25.80609  1.000 39.81121  ? 111 THR A HG1  1 
ATOM   1732 H HG21 . THR A 1 111 ? -15.77563 -22.74583 24.94347  1.000 39.92422  ? 111 THR A HG21 1 
ATOM   1733 H HG22 . THR A 1 111 ? -15.72104 -22.70143 23.36627  1.000 39.92422  ? 111 THR A HG22 1 
ATOM   1734 H HG23 . THR A 1 111 ? -17.11015 -22.83463 24.10462  1.000 39.92422  ? 111 THR A HG23 1 
ATOM   1735 N N    . PHE A 1 112 ? -15.92464 -26.98260 22.16710  1.000 26.81876  ? 112 PHE A N    1 
ATOM   1736 C CA   . PHE A 1 112 ? -15.57569 -28.36929 21.88549  1.000 28.97303  ? 112 PHE A CA   1 
ATOM   1737 C C    . PHE A 1 112 ? -14.17175 -28.38894 21.30548  1.000 27.15809  ? 112 PHE A C    1 
ATOM   1738 O O    . PHE A 1 112 ? -13.63404 -27.36296 20.90997  1.000 30.00663  ? 112 PHE A O    1 
ATOM   1739 C CB   . PHE A 1 112 ? -16.58726 -29.01449 20.93686  1.000 28.74730  ? 112 PHE A CB   1 
ATOM   1740 C CG   . PHE A 1 112 ? -16.74191 -28.30089 19.62659  1.000 29.33063  ? 112 PHE A CG   1 
ATOM   1741 C CD1  . PHE A 1 112 ? -15.95687 -28.63657 18.53487  1.000 26.17391  ? 112 PHE A CD1  1 
ATOM   1742 C CD2  . PHE A 1 112 ? -17.68935 -27.29045 19.47816  1.000 32.94391  ? 112 PHE A CD2  1 
ATOM   1743 C CE1  . PHE A 1 112 ? -16.12084 -27.99627 17.30728  1.000 25.91873  ? 112 PHE A CE1  1 
ATOM   1744 C CE2  . PHE A 1 112 ? -17.84844 -26.66256 18.25962  1.000 31.13581  ? 112 PHE A CE2  1 
ATOM   1745 C CZ   . PHE A 1 112 ? -17.06153 -27.02179 17.16985  1.000 28.66876  ? 112 PHE A CZ   1 
ATOM   1746 H H    . PHE A 1 112 ? -15.41598 -26.40941 21.77682  1.000 32.23661  ? 112 PHE A H    1 
ATOM   1747 H HA   . PHE A 1 112 ? -15.57229 -28.88290 22.70835  1.000 34.82174  ? 112 PHE A HA   1 
ATOM   1748 H HB2  . PHE A 1 112 ? -16.29946 -29.92097 20.74615  1.000 34.55086  ? 112 PHE A HB2  1 
ATOM   1749 H HB3  . PHE A 1 112 ? -17.45515 -29.02614 21.36990  1.000 34.55086  ? 112 PHE A HB3  1 
ATOM   1750 H HD1  . PHE A 1 112 ? -15.31046 -29.29943 18.62254  1.000 31.46279  ? 112 PHE A HD1  1 
ATOM   1751 H HD2  . PHE A 1 112 ? -18.21595 -27.03841 20.20209  1.000 39.58679  ? 112 PHE A HD2  1 
ATOM   1752 H HE1  . PHE A 1 112 ? -15.58822 -28.23460 16.58312  1.000 31.15657  ? 112 PHE A HE1  1 
ATOM   1753 H HE2  . PHE A 1 112 ? -18.48737 -25.99330 18.16600  1.000 37.41708  ? 112 PHE A HE2  1 
ATOM   1754 H HZ   . PHE A 1 112 ? -17.17775 -26.59768 16.35038  1.000 34.45661  ? 112 PHE A HZ   1 
ATOM   1755 N N    . SER A 1 113 ? -13.56699 -29.58050 21.26911  1.000 24.75886  ? 113 SER A N    1 
ATOM   1756 C CA   . SER A 1 113 ? -12.20855 -29.76265 20.80766  1.000 26.19546  ? 113 SER A CA   1 
ATOM   1757 C C    . SER A 1 113 ? -12.32859 -30.25127 19.36966  1.000 29.56119  ? 113 SER A C    1 
ATOM   1758 O O    . SER A 1 113 ? -13.19274 -31.10541 19.10700  1.000 26.43575  ? 113 SER A O    1 
ATOM   1759 C CB   . SER A 1 113 ? -11.44234 -30.80790 21.61374  1.000 29.33265  ? 113 SER A CB   1 
ATOM   1760 O OG   . SER A 1 113 ? -11.24632 -30.45801 22.97360  1.000 31.97455  ? 113 SER A OG   1 
ATOM   1761 H H    . SER A 1 113 ? -13.94293 -30.31349 21.51608  1.000 29.76473  ? 113 SER A H    1 
ATOM   1762 H HA   . SER A 1 113 ? -11.70783 -28.93559 20.88604  1.000 31.48865  ? 113 SER A HA   1 
ATOM   1763 H HB2  . SER A 1 113 ? -11.94129 -31.63919 21.58369  1.000 35.25328  ? 113 SER A HB2  1 
ATOM   1764 H HB3  . SER A 1 113 ? -10.57172 -30.92850 21.20341  1.000 35.25328  ? 113 SER A HB3  1 
ATOM   1765 H HG   . SER A 1 113 ? -10.67879 -29.84155 23.03271  1.000 38.42356  ? 113 SER A HG   1 
ATOM   1766 N N    . VAL A 1 114 ? -11.49939 -29.71391 18.48297  1.000 27.70291  ? 114 VAL A N    1 
ATOM   1767 C CA   . VAL A 1 114 ? -11.34972 -30.19658 17.09863  1.000 23.90294  ? 114 VAL A CA   1 
ATOM   1768 C C    . VAL A 1 114 ? -10.07236 -31.01153 16.97388  1.000 26.97969  ? 114 VAL A C    1 
ATOM   1769 O O    . VAL A 1 114 ? -8.99366  -30.56741 17.37143  1.000 27.21054  ? 114 VAL A O    1 
ATOM   1770 C CB   . VAL A 1 114 ? -11.35259 -29.01688 16.11229  1.000 27.95655  ? 114 VAL A CB   1 
ATOM   1771 C CG1  . VAL A 1 114 ? -10.98949 -29.51213 14.68182  1.000 31.21307  ? 114 VAL A CG1  1 
ATOM   1772 C CG2  . VAL A 1 114 ? -12.70019 -28.33500 16.13982  1.000 28.52280  ? 114 VAL A CG2  1 
ATOM   1773 H H    . VAL A 1 114 ? -10.99045 -29.04328 18.65856  1.000 33.29759  ? 114 VAL A H    1 
ATOM   1774 H HA   . VAL A 1 114 ? -12.08939 -30.78811 16.88913  1.000 28.73763  ? 114 VAL A HA   1 
ATOM   1775 H HB   . VAL A 1 114 ? -10.68272 -28.36523 16.37214  1.000 33.60197  ? 114 VAL A HB   1 
ATOM   1776 H HG11 . VAL A 1 114 ? -11.52415 -30.29412 14.47318  1.000 37.50979  ? 114 VAL A HG11 1 
ATOM   1777 H HG12 . VAL A 1 114 ? -11.17650 -28.80422 14.04559  1.000 37.50979  ? 114 VAL A HG12 1 
ATOM   1778 H HG13 . VAL A 1 114 ? -10.04686 -29.73946 14.65612  1.000 37.50979  ? 114 VAL A HG13 1 
ATOM   1779 H HG21 . VAL A 1 114 ? -12.71265 -27.68926 16.86353  1.000 34.28147  ? 114 VAL A HG21 1 
ATOM   1780 H HG22 . VAL A 1 114 ? -12.84384 -27.88509 15.29256  1.000 34.28147  ? 114 VAL A HG22 1 
ATOM   1781 H HG23 . VAL A 1 114 ? -13.38930 -29.00299 16.28063  1.000 34.28147  ? 114 VAL A HG23 1 
ATOM   1782 N N    . LEU A 1 115 ? -10.19040 -32.20436 16.39045  1.000 28.87061  ? 115 LEU A N    1 
ATOM   1783 C CA   . LEU A 1 115 ? -9.06476  -33.05782 16.06719  1.000 26.28042  ? 115 LEU A CA   1 
ATOM   1784 C C    . LEU A 1 115 ? -8.92829  -32.89535 14.55095  1.000 28.40717  ? 115 LEU A C    1 
ATOM   1785 O O    . LEU A 1 115 ? -9.65831  -33.53273 13.78597  1.000 28.43144  ? 115 LEU A O    1 
ATOM   1786 C CB   . LEU A 1 115 ? -9.28250  -34.50754 16.48717  1.000 27.45395  ? 115 LEU A CB   1 
ATOM   1787 C CG   . LEU A 1 115 ? -8.06144  -35.39081 16.19557  1.000 30.09681  ? 115 LEU A CG   1 
ATOM   1788 C CD1  . LEU A 1 115 ? -6.80662  -34.94936 16.99629  1.000 34.07183  ? 115 LEU A CD1  1 
ATOM   1789 C CD2  . LEU A 1 115 ? -8.33086  -36.86205 16.47479  1.000 31.52656  ? 115 LEU A CD2  1 
ATOM   1790 H H    . LEU A 1 115 ? -10.94617 -32.54804 16.16617  1.000 34.69884  ? 115 LEU A H    1 
ATOM   1791 H HA   . LEU A 1 115 ? -8.25875  -32.78174 16.53090  1.000 31.59060  ? 115 LEU A HA   1 
ATOM   1792 H HB2  . LEU A 1 115 ? -9.45698  -34.53787 17.44086  1.000 32.99884  ? 115 LEU A HB2  1 
ATOM   1793 H HB3  . LEU A 1 115 ? -10.03980 -34.86783 15.99973  1.000 32.99884  ? 115 LEU A HB3  1 
ATOM   1794 H HG   . LEU A 1 115 ? -7.87828  -35.28319 15.24912  1.000 36.17027  ? 115 LEU A HG   1 
ATOM   1795 H HD11 . LEU A 1 115 ? -6.78203  -35.43301 17.83675  1.000 40.94029  ? 115 LEU A HD11 1 
ATOM   1796 H HD12 . LEU A 1 115 ? -6.01310  -35.15012 16.47578  1.000 40.94029  ? 115 LEU A HD12 1 
ATOM   1797 H HD13 . LEU A 1 115 ? -6.85903  -33.99557 17.16493  1.000 40.94029  ? 115 LEU A HD13 1 
ATOM   1798 H HD21 . LEU A 1 115 ? -7.48515  -37.33495 16.51993  1.000 37.88598  ? 115 LEU A HD21 1 
ATOM   1799 H HD22 . LEU A 1 115 ? -8.80025  -36.94231 17.31985  1.000 37.88598  ? 115 LEU A HD22 1 
ATOM   1800 H HD23 . LEU A 1 115 ? -8.87494  -37.22496 15.75843  1.000 37.88598  ? 115 LEU A HD23 1 
ATOM   1801 N N    . ALA A 1 116 ? -8.02872  -32.00101 14.16523  1.000 24.41765  ? 116 ALA A N    1 
ATOM   1802 C CA   . ALA A 1 116 ? -7.77820  -31.71572 12.75578  1.000 24.45444  ? 116 ALA A CA   1 
ATOM   1803 C C    . ALA A 1 116 ? -6.99977  -32.87225 12.17621  1.000 27.96320  ? 116 ALA A C    1 
ATOM   1804 O O    . ALA A 1 116 ? -6.04469  -33.34074 12.80255  1.000 29.18221  ? 116 ALA A O    1 
ATOM   1805 C CB   . ALA A 1 116 ? -6.98408  -30.42585 12.58937  1.000 26.12560  ? 116 ALA A CB   1 
ATOM   1806 H H    . ALA A 1 116 ? -7.54309  -31.53900 14.70403  1.000 29.35528  ? 116 ALA A H    1 
ATOM   1807 H HA   . ALA A 1 116 ? -8.61825  -31.60041 12.28470  1.000 29.39943  ? 116 ALA A HA   1 
ATOM   1808 H HB1  . ALA A 1 116 ? -6.82009  -30.27553 11.64522  1.000 31.40482  ? 116 ALA A HB1  1 
ATOM   1809 H HB2  . ALA A 1 116 ? -7.49711  -29.68944 12.95734  1.000 31.40482  ? 116 ALA A HB2  1 
ATOM   1810 H HB3  . ALA A 1 116 ? -6.14132  -30.51064 13.06208  1.000 31.40482  ? 116 ALA A HB3  1 
ATOM   1811 N N    . CYS A 1 117 ? -7.46762  -33.38559 11.03552  1.000 26.18875  ? 117 CYS A N    1 
ATOM   1812 C CA   . CYS A 1 117 ? -6.90431  -34.59409 10.42527  1.000 26.64890  ? 117 CYS A CA   1 
ATOM   1813 C C    . CYS A 1 117 ? -6.73523  -34.38532 8.92208   1.000 31.62222  ? 117 CYS A C    1 
ATOM   1814 O O    . CYS A 1 117 ? -7.51079  -33.64934 8.31387   1.000 25.04261  ? 117 CYS A O    1 
ATOM   1815 C CB   . CYS A 1 117 ? -7.80219  -35.83068 10.61311  1.000 34.36525  ? 117 CYS A CB   1 
ATOM   1816 S SG   . CYS A 1 117 ? -8.02505  -36.32284 12.31376  1.000 35.43736  ? 117 CYS A SG   1 
ATOM   1817 H H    . CYS A 1 117 ? -8.12032  -33.04734 10.58924  1.000 31.48060  ? 117 CYS A H    1 
ATOM   1818 H HA   . CYS A 1 117 ? -6.04224  -34.75394 10.84023  1.000 32.03279  ? 117 CYS A HA   1 
ATOM   1819 H HB2  . CYS A 1 117 ? -8.67864  -35.63580 10.24601  1.000 41.29240  ? 117 CYS A HB2  1 
ATOM   1820 H HB3  . CYS A 1 117 ? -7.40322  -36.57791 10.14050  1.000 41.29240  ? 117 CYS A HB3  1 
ATOM   1821 H HG   . CYS A 1 117 ? -9.18955  -36.53670 12.50919  1.000 42.57893  ? 117 CYS A HG   1 
ATOM   1822 N N    . TYR A 1 118 ? -5.74923  -35.09224 8.33486   1.000 30.63792  ? 118 TYR A N    1 
ATOM   1823 C CA   . TYR A 1 118 ? -5.50211  -35.18754 6.88695   1.000 29.69039  ? 118 TYR A CA   1 
ATOM   1824 C C    . TYR A 1 118 ? -5.22498  -36.65347 6.53469   1.000 32.10037  ? 118 TYR A C    1 
ATOM   1825 O O    . TYR A 1 118 ? -4.52226  -37.35328 7.26389   1.000 30.42332  ? 118 TYR A O    1 
ATOM   1826 C CB   . TYR A 1 118 ? -4.34651  -34.25477 6.45376   1.000 32.22326  ? 118 TYR A CB   1 
ATOM   1827 C CG   . TYR A 1 118 ? -4.68243  -32.79888 6.78803   1.000 33.43789  ? 118 TYR A CG   1 
ATOM   1828 C CD1  . TYR A 1 118 ? -5.41231  -32.00979 5.90143   1.000 35.02218  ? 118 TYR A CD1  1 
ATOM   1829 C CD2  . TYR A 1 118 ? -4.35705  -32.25360 8.02475   1.000 36.03798  ? 118 TYR A CD2  1 
ATOM   1830 C CE1  . TYR A 1 118 ? -5.78535  -30.72705 6.23294   1.000 30.70615  ? 118 TYR A CE1  1 
ATOM   1831 C CE2  . TYR A 1 118 ? -4.72425  -30.95621 8.36697   1.000 34.68171  ? 118 TYR A CE2  1 
ATOM   1832 C CZ   . TYR A 1 118 ? -5.43622  -30.19105 7.46091   1.000 34.68722  ? 118 TYR A CZ   1 
ATOM   1833 O OH   . TYR A 1 118 ? -5.80909  -28.91320 7.80226   1.000 32.62705  ? 118 TYR A OH   1 
ATOM   1834 H H    . TYR A 1 118 ? -5.17753  -35.55181 8.78381   1.000 36.81960  ? 118 TYR A H    1 
ATOM   1835 H HA   . TYR A 1 118 ? -6.28370  -34.91435 6.38158   1.000 35.68258  ? 118 TYR A HA   1 
ATOM   1836 H HB2  . TYR A 1 118 ? -3.53547  -34.50211 6.92486   1.000 38.72201  ? 118 TYR A HB2  1 
ATOM   1837 H HB3  . TYR A 1 118 ? -4.21005  -34.32978 5.49634   1.000 38.72201  ? 118 TYR A HB3  1 
ATOM   1838 H HD1  . TYR A 1 118 ? -5.65139  -32.35558 5.07187   1.000 42.08072  ? 118 TYR A HD1  1 
ATOM   1839 H HD2  . TYR A 1 118 ? -3.88292  -32.76807 8.63747   1.000 43.29967  ? 118 TYR A HD2  1 
ATOM   1840 H HE1  . TYR A 1 118 ? -6.27488  -30.21726 5.62848   1.000 36.90148  ? 118 TYR A HE1  1 
ATOM   1841 H HE2  . TYR A 1 118 ? -4.49321  -30.60656 9.19719   1.000 41.67215  ? 118 TYR A HE2  1 
ATOM   1842 H HH   . TYR A 1 118 ? -5.36721  -28.65303 8.46758   1.000 39.20657  ? 118 TYR A HH   1 
ATOM   1843 N N    . ASN A 1 119 ? -5.84196  -37.12602 5.45100   1.000 36.03479  ? 119 ASN A N    1 
ATOM   1844 C CA   . ASN A 1 119 ? -5.64170  -38.50177 4.96637   1.000 35.70259  ? 119 ASN A CA   1 
ATOM   1845 C C    . ASN A 1 119 ? -5.85563  -39.51832 6.08354   1.000 36.75715  ? 119 ASN A C    1 
ATOM   1846 O O    . ASN A 1 119 ? -5.15630  -40.53052 6.19372   1.000 35.79219  ? 119 ASN A O    1 
ATOM   1847 C CB   . ASN A 1 119 ? -4.25145  -38.65737 4.34636   1.000 37.30138  ? 119 ASN A CB   1 
ATOM   1848 C CG   . ASN A 1 119 ? -4.01582  -37.68119 3.21650   1.000 40.56201  ? 119 ASN A CG   1 
ATOM   1849 O OD1  . ASN A 1 119 ? -4.59235  -37.81692 2.13694   1.000 49.41764  ? 119 ASN A OD1  1 
ATOM   1850 N ND2  . ASN A 1 119 ? -3.16746  -36.69159 3.45641   1.000 46.21586  ? 119 ASN A ND2  1 
ATOM   1851 H H    . ASN A 1 119 ? -6.38853  -36.66760 4.97068   1.000 43.29585  ? 119 ASN A H    1 
ATOM   1852 H HA   . ASN A 1 119 ? -6.30274  -38.68450 4.28041   1.000 42.89720  ? 119 ASN A HA   1 
ATOM   1853 H HB2  . ASN A 1 119 ? -3.57973  -38.49845 5.02786   1.000 44.81576  ? 119 ASN A HB2  1 
ATOM   1854 H HB3  . ASN A 1 119 ? -4.15954  -39.55609 3.99315   1.000 44.81576  ? 119 ASN A HB3  1 
ATOM   1855 H HD21 . ASN A 1 119 ? -3.00046  -36.11058 2.84474   1.000 55.51314  ? 119 ASN A HD21 1 
ATOM   1856 H HD22 . ASN A 1 119 ? -2.78398  -36.63047 4.22374   1.000 55.51314  ? 119 ASN A HD22 1 
ATOM   1857 N N    . GLY A 1 120 ? -6.82235  -39.22668 6.94969   1.000 29.31995  ? 120 GLY A N    1 
ATOM   1858 C CA   . GLY A 1 120 ? -7.12474  -40.11624 8.02218   1.000 29.99548  ? 120 GLY A CA   1 
ATOM   1859 C C    . GLY A 1 120 ? -6.16872  -40.11871 9.18467   1.000 31.23962  ? 120 GLY A C    1 
ATOM   1860 O O    . GLY A 1 120 ? -6.34304  -40.95049 10.09507  1.000 35.06737  ? 120 GLY A O    1 
ATOM   1861 H H    . GLY A 1 120 ? -7.30719  -38.51686 6.92353   1.000 35.23804  ? 120 GLY A H    1 
ATOM   1862 H HA2  . GLY A 1 120 ? -8.00073  -39.88641 8.36964   1.000 36.04867  ? 120 GLY A HA2  1 
ATOM   1863 H HA3  . GLY A 1 120 ? -7.15199  -41.01935 7.66924   1.000 36.04867  ? 120 GLY A HA3  1 
ATOM   1864 N N    A SER A 1 121 ? -5.21327  -39.20080 9.23305   0.608 30.76667  ? 121 SER A N    1 
ATOM   1865 N N    B SER A 1 121 ? -5.18539  -39.21259 9.21024   0.392 31.46100  ? 121 SER A N    1 
ATOM   1866 C CA   A SER A 1 121 ? -4.24000  -39.19412 10.30808  0.608 33.14131  ? 121 SER A CA   1 
ATOM   1867 C CA   B SER A 1 121 ? -4.18926  -39.15975 10.27739  0.392 32.80299  ? 121 SER A CA   1 
ATOM   1868 C C    A SER A 1 121 ? -4.32477  -37.89729 11.10505  0.608 32.51365  ? 121 SER A C    1 
ATOM   1869 C C    B SER A 1 121 ? -4.34719  -37.88558 11.09629  0.392 32.71608  ? 121 SER A C    1 
ATOM   1870 O O    A SER A 1 121 ? -4.27084  -36.79976 10.52294  0.608 30.39984  ? 121 SER A O    1 
ATOM   1871 O O    B SER A 1 121 ? -4.35046  -36.78586 10.52217  0.392 30.63825  ? 121 SER A O    1 
ATOM   1872 C CB   A SER A 1 121 ? -2.82040  -39.38635 9.74805   0.608 37.59604  ? 121 SER A CB   1 
ATOM   1873 C CB   B SER A 1 121 ? -2.76988  -39.21777 9.68763   0.392 37.28323  ? 121 SER A CB   1 
ATOM   1874 O OG   A SER A 1 121 ? -2.69291  -40.71475 9.25651   0.608 36.53983  ? 121 SER A OG   1 
ATOM   1875 O OG   B SER A 1 121 ? -1.80024  -38.92963 10.67515  0.392 33.48405  ? 121 SER A OG   1 
ATOM   1876 H H    A SER A 1 121 ? -5.11070  -38.57338 8.65389   0.608 36.97410  ? 121 SER A H    1 
ATOM   1877 H H    B SER A 1 121 ? -5.07496  -38.60837 8.60831   0.392 37.80730  ? 121 SER A H    1 
ATOM   1878 H HA   A SER A 1 121 ? -4.43318  -39.92271 10.91861  0.608 39.82367  ? 121 SER A HA   1 
ATOM   1879 H HA   B SER A 1 121 ? -4.31726  -39.91962 10.86655  0.392 39.41769  ? 121 SER A HA   1 
ATOM   1880 H HB2  A SER A 1 121 ? -2.67076  -38.75820 9.02422   0.608 45.16935  ? 121 SER A HB2  1 
ATOM   1881 H HB2  B SER A 1 121 ? -2.60955  -40.10850 9.33865   0.392 44.79398  ? 121 SER A HB2  1 
ATOM   1882 H HB3  A SER A 1 121 ? -2.17180  -39.23944 10.45420  0.608 45.16935  ? 121 SER A HB3  1 
ATOM   1883 H HB3  B SER A 1 121 ? -2.69769  -38.56412 8.97459   0.392 44.79398  ? 121 SER A HB3  1 
ATOM   1884 H HG   A SER A 1 121 ? -3.24091  -40.84427 8.63319   0.608 43.90189  ? 121 SER A HG   1 
ATOM   1885 H HG   B SER A 1 121 ? -1.84465  -39.49486 11.29495  0.392 40.23496  ? 121 SER A HG   1 
ATOM   1886 N N    . PRO A 1 122 ? -4.46216  -37.97422 12.41912  1.000 35.05204  ? 122 PRO A N    1 
ATOM   1887 C CA   . PRO A 1 122 ? -4.54678  -36.76367 13.23572  1.000 33.07503  ? 122 PRO A CA   1 
ATOM   1888 C C    . PRO A 1 122 ? -3.32452  -35.87804 13.08603  1.000 32.71503  ? 122 PRO A C    1 
ATOM   1889 O O    . PRO A 1 122 ? -2.18592  -36.34388 13.09288  1.000 40.77177  ? 122 PRO A O    1 
ATOM   1890 C CB   . PRO A 1 122 ? -4.66950  -37.30460 14.66532  1.000 36.74780  ? 122 PRO A CB   1 
ATOM   1891 C CG   . PRO A 1 122 ? -5.38519  -38.61678 14.50687  1.000 43.25803  ? 122 PRO A CG   1 
ATOM   1892 C CD   . PRO A 1 122 ? -4.77927  -39.18948 13.21050  1.000 41.54429  ? 122 PRO A CD   1 
ATOM   1893 H HA   . PRO A 1 122 ? -5.33976  -36.25882 12.99657  1.000 39.74414  ? 122 PRO A HA   1 
ATOM   1894 H HB2  . PRO A 1 122 ? -3.78810  -37.43144 15.04995  1.000 44.15146  ? 122 PRO A HB2  1 
ATOM   1895 H HB3  . PRO A 1 122 ? -5.18415  -36.68944 15.21086  1.000 44.15146  ? 122 PRO A HB3  1 
ATOM   1896 H HG2  . PRO A 1 122 ? -5.20633  -39.19367 15.26589  1.000 51.96374  ? 122 PRO A HG2  1 
ATOM   1897 H HG3  . PRO A 1 122 ? -6.34026  -38.47275 14.41742  1.000 51.96374  ? 122 PRO A HG3  1 
ATOM   1898 H HD2  . PRO A 1 122 ? -3.97532  -39.69805 13.40000  1.000 49.90725  ? 122 PRO A HD2  1 
ATOM   1899 H HD3  . PRO A 1 122 ? -5.42247  -39.74686 12.74517  1.000 49.90725  ? 122 PRO A HD3  1 
ATOM   1900 N N    . SER A 1 123 ? -3.58144  -34.57986 12.93094  1.000 32.05653  ? 123 SER A N    1 
ATOM   1901 C CA   . SER A 1 123 ? -2.60403  -33.51545 12.79472  1.000 28.12856  ? 123 SER A CA   1 
ATOM   1902 C C    . SER A 1 123 ? -2.44696  -32.66683 14.04788  1.000 30.24873  ? 123 SER A C    1 
ATOM   1903 O O    . SER A 1 123 ? -1.33918  -32.26366 14.38317  1.000 32.96366  ? 123 SER A O    1 
ATOM   1904 C CB   . SER A 1 123 ? -3.01582  -32.61846 11.61192  1.000 35.20197  ? 123 SER A CB   1 
ATOM   1905 O OG   . SER A 1 123 ? -2.04989  -31.64595 11.29793  1.000 47.56087  ? 123 SER A OG   1 
ATOM   1906 H H    . SER A 1 123 ? -4.38332  -34.27064 12.89964  1.000 38.52193  ? 123 SER A H    1 
ATOM   1907 H HA   . SER A 1 123 ? -1.73212  -33.89655 12.60648  1.000 33.80837  ? 123 SER A HA   1 
ATOM   1908 H HB2  . SER A 1 123 ? -3.15057  -33.18028 10.83275  1.000 42.29647  ? 123 SER A HB2  1 
ATOM   1909 H HB3  . SER A 1 123 ? -3.84277  -32.16683 11.84229  1.000 42.29647  ? 123 SER A HB3  1 
ATOM   1910 H HG   . SER A 1 123 ? -2.31429  -31.17584 10.65397  1.000 57.12714  ? 123 SER A HG   1 
ATOM   1911 N N    . GLY A 1 124 ? -3.51002  -32.41752 14.80020  1.000 29.57084  ? 124 GLY A N    1 
ATOM   1912 C CA   . GLY A 1 124 ? -3.38771  -31.47184 15.88998  1.000 29.60578  ? 124 GLY A CA   1 
ATOM   1913 C C    . GLY A 1 124 ? -4.73325  -31.25205 16.53696  1.000 26.72177  ? 124 GLY A C    1 
ATOM   1914 O O    . GLY A 1 124 ? -5.78349  -31.60684 15.95728  1.000 30.51682  ? 124 GLY A O    1 
ATOM   1915 H H    . GLY A 1 124 ? -4.28663  -32.77323 14.70047  1.000 35.53911  ? 124 GLY A H    1 
ATOM   1916 H HA2  . GLY A 1 124 ? -2.76937  -31.81285 16.55501  1.000 35.58103  ? 124 GLY A HA2  1 
ATOM   1917 H HA3  . GLY A 1 124 ? -3.05579  -30.62399 15.55549  1.000 35.58103  ? 124 GLY A HA3  1 
ATOM   1918 N N    . VAL A 1 125 ? -4.75880  -30.70608 17.75029  1.000 27.98627  ? 125 VAL A N    1 
ATOM   1919 C CA   . VAL A 1 125 ? -5.99446  -30.53244 18.48073  1.000 28.38076  ? 125 VAL A CA   1 
ATOM   1920 C C    . VAL A 1 125 ? -6.08316  -29.12448 19.06079  1.000 28.36414  ? 125 VAL A C    1 
ATOM   1921 O O    . VAL A 1 125 ? -5.08735  -28.56655 19.53420  1.000 31.65572  ? 125 VAL A O    1 
ATOM   1922 C CB   . VAL A 1 125 ? -6.12464  -31.60808 19.59151  1.000 31.11727  ? 125 VAL A CB   1 
ATOM   1923 C CG1  . VAL A 1 125 ? -5.11386  -31.37630 20.69520  1.000 42.76668  ? 125 VAL A CG1  1 
ATOM   1924 C CG2  . VAL A 1 125 ? -7.51530  -31.61469 20.18129  1.000 33.77716  ? 125 VAL A CG2  1 
ATOM   1925 H H    . VAL A 1 125 ? -4.06119  -30.42782 18.16924  1.000 33.63763  ? 125 VAL A H    1 
ATOM   1926 H HA   . VAL A 1 125 ? -6.73845  -30.61515 17.86385  1.000 34.11101  ? 125 VAL A HA   1 
ATOM   1927 H HB   . VAL A 1 125 ? -5.95250  -32.47179 19.18498  1.000 37.39483  ? 125 VAL A HB   1 
ATOM   1928 H HG11 . VAL A 1 125 ? -4.54941  -30.62526 20.45388  1.000 51.37412  ? 125 VAL A HG11 1 
ATOM   1929 H HG12 . VAL A 1 125 ? -5.58592  -31.18359 21.52038  1.000 51.37412  ? 125 VAL A HG12 1 
ATOM   1930 H HG13 . VAL A 1 125 ? -4.57393  -32.17506 20.80180  1.000 51.37412  ? 125 VAL A HG13 1 
ATOM   1931 H HG21 . VAL A 1 125 ? -7.56546  -32.30178 20.86414  1.000 40.58669  ? 125 VAL A HG21 1 
ATOM   1932 H HG22 . VAL A 1 125 ? -7.69658  -30.74575 20.57242  1.000 40.58669  ? 125 VAL A HG22 1 
ATOM   1933 H HG23 . VAL A 1 125 ? -8.15605  -31.80068 19.47720  1.000 40.58669  ? 125 VAL A HG23 1 
ATOM   1934 N N    . TYR A 1 126 ? -7.29363  -28.56319 19.02793  1.000 29.54669  ? 126 TYR A N    1 
ATOM   1935 C CA   . TYR A 1 126 ? -7.50776  -27.21066 19.52517  1.000 27.73078  ? 126 TYR A CA   1 
ATOM   1936 C C    . TYR A 1 126 ? -8.97867  -26.98817 19.85322  1.000 28.02100  ? 126 TYR A C    1 
ATOM   1937 O O    . TYR A 1 126 ? -9.86774  -27.63784 19.29645  1.000 29.47645  ? 126 TYR A O    1 
ATOM   1938 C CB   . TYR A 1 126 ? -7.03759  -26.16401 18.49866  1.000 25.89176  ? 126 TYR A CB   1 
ATOM   1939 C CG   . TYR A 1 126 ? -7.61272  -26.28164 17.11133  1.000 26.87793  ? 126 TYR A CG   1 
ATOM   1940 C CD1  . TYR A 1 126 ? -8.79440  -25.64509 16.76548  1.000 31.73195  ? 126 TYR A CD1  1 
ATOM   1941 C CD2  . TYR A 1 126 ? -6.96423  -27.00182 16.13042  1.000 34.27435  ? 126 TYR A CD2  1 
ATOM   1942 C CE1  . TYR A 1 126 ? -9.29500  -25.75137 15.46257  1.000 28.91313  ? 126 TYR A CE1  1 
ATOM   1943 C CE2  . TYR A 1 126 ? -7.46569  -27.10820 14.86379  1.000 31.90432  ? 126 TYR A CE2  1 
ATOM   1944 C CZ   . TYR A 1 126 ? -8.62626  -26.48107 14.53361  1.000 34.26780  ? 126 TYR A CZ   1 
ATOM   1945 O OH   . TYR A 1 126 ? -9.09964  -26.56927 13.23381  1.000 33.53343  ? 126 TYR A OH   1 
ATOM   1946 H H    . TYR A 1 126 ? -8.00100  -28.94595 18.72342  1.000 35.51013  ? 126 TYR A H    1 
ATOM   1947 H HA   . TYR A 1 126 ? -7.00775  -27.10936 20.35018  1.000 33.33103  ? 126 TYR A HA   1 
ATOM   1948 H HB2  . TYR A 1 126 ? -7.27692  -25.28531 18.83261  1.000 31.12421  ? 126 TYR A HB2  1 
ATOM   1949 H HB3  . TYR A 1 126 ? -6.07392  -26.23578 18.41449  1.000 31.12421  ? 126 TYR A HB3  1 
ATOM   1950 H HD1  . TYR A 1 126 ? -9.25573  -25.14624 17.40049  1.000 38.13244  ? 126 TYR A HD1  1 
ATOM   1951 H HD2  . TYR A 1 126 ? -6.16324  -27.42699 16.33667  1.000 41.18332  ? 126 TYR A HD2  1 
ATOM   1952 H HE1  . TYR A 1 126 ? -10.08702 -25.32136 15.23302  1.000 34.74986  ? 126 TYR A HE1  1 
ATOM   1953 H HE2  . TYR A 1 126 ? -7.01220  -27.61068 14.22601  1.000 38.33928  ? 126 TYR A HE2  1 
ATOM   1954 H HH   . TYR A 1 126 ? -8.47780  -26.79536 12.71631  1.000 40.29421  ? 126 TYR A HH   1 
ATOM   1955 N N    . GLN A 1 127 ? -9.21978  -26.01130 20.72521  1.000 26.17959  ? 127 GLN A N    1 
ATOM   1956 C CA   . GLN A 1 127 ? -10.57243 -25.67846 21.17742  1.000 27.96253  ? 127 GLN A CA   1 
ATOM   1957 C C    . GLN A 1 127 ? -11.26271 -24.68754 20.24927  1.000 30.47477  ? 127 GLN A C    1 
ATOM   1958 O O    . GLN A 1 127 ? -10.65533 -23.72075 19.80119  1.000 34.94411  ? 127 GLN A O    1 
ATOM   1959 C CB   . GLN A 1 127 ? -10.53734 -25.00632 22.56232  1.000 30.13005  ? 127 GLN A CB   1 
ATOM   1960 C CG   . GLN A 1 127 ? -10.35890 -25.85764 23.71522  1.000 37.26262  ? 127 GLN A CG   1 
ATOM   1961 C CD   . GLN A 1 127 ? -11.52969 -26.79572 23.90616  1.000 36.04205  ? 127 GLN A CD   1 
ATOM   1962 O OE1  . GLN A 1 127 ? -11.51048 -27.90981 23.38939  1.000 37.41563  ? 127 GLN A OE1  1 
ATOM   1963 N NE2  . GLN A 1 127 ? -12.53076 -26.37647 24.69131  1.000 36.94327  ? 127 GLN A NE2  1 
ATOM   1964 H H    . GLN A 1 127 ? -8.60848  -25.51833 21.07577  1.000 31.46961  ? 127 GLN A H    1 
ATOM   1965 H HA   . GLN A 1 127 ? -11.07007 -26.51081 21.19881  1.000 33.60914  ? 127 GLN A HA   1 
ATOM   1966 H HB2  . GLN A 1 127 ? -9.80272  -24.37291 22.56621  1.000 36.21016  ? 127 GLN A HB2  1 
ATOM   1967 H HB3  . GLN A 1 127 ? -11.37848 -24.53959 22.68702  1.000 36.21016  ? 127 GLN A HB3  1 
ATOM   1968 H HG2  . GLN A 1 127 ? -9.55752  -26.39140 23.59779  1.000 44.76925  ? 127 GLN A HG2  1 
ATOM   1969 H HG3  . GLN A 1 127 ? -10.27745 -25.30725 24.50978  1.000 44.76925  ? 127 GLN A HG3  1 
ATOM   1970 H HE21 . GLN A 1 127 ? -12.49044 -25.60184 25.06270  1.000 44.38602  ? 127 GLN A HE21 1 
ATOM   1971 H HE22 . GLN A 1 127 ? -13.21377 -26.88192 24.82398  1.000 44.38602  ? 127 GLN A HE22 1 
ATOM   1972 N N    . CYS A 1 128 ? -12.57688 -24.85838 20.09305  1.000 28.86718  ? 128 CYS A N    1 
ATOM   1973 C CA   . CYS A 1 128 ? -13.38349 -23.93852 19.30960  1.000 29.42699  ? 128 CYS A CA   1 
ATOM   1974 C C    . CYS A 1 128 ? -14.70558 -23.71557 20.03167  1.000 29.62631  ? 128 CYS A C    1 
ATOM   1975 O O    . CYS A 1 128 ? -15.22900 -24.60841 20.70335  1.000 30.21953  ? 128 CYS A O    1 
ATOM   1976 C CB   . CYS A 1 128 ? -13.72124 -24.45592 17.91220  1.000 31.88210  ? 128 CYS A CB   1 
ATOM   1977 S SG   . CYS A 1 128 ? -12.37859 -24.45568 16.73418  1.000 32.56159  ? 128 CYS A SG   1 
ATOM   1978 H H    . CYS A 1 128 ? -13.02348 -25.50796 20.43686  1.000 34.69472  ? 128 CYS A H    1 
ATOM   1979 H HA   . CYS A 1 128 ? -12.88309 -23.11228 19.22107  1.000 35.36649  ? 128 CYS A HA   1 
ATOM   1980 H HB2  . CYS A 1 128 ? -14.03077 -25.37152 17.99439  1.000 38.31262  ? 128 CYS A HB2  1 
ATOM   1981 H HB3  . CYS A 1 128 ? -14.42556 -23.89933 17.54472  1.000 38.31262  ? 128 CYS A HB3  1 
ATOM   1982 H HG   . CYS A 1 128 ? -12.11500 -23.32191 16.44247  1.000 39.12801  ? 128 CYS A HG   1 
ATOM   1983 N N    . ALA A 1 129 ? -15.25071 -22.51821 19.87129  1.000 29.84342  ? 129 ALA A N    1 
ATOM   1984 C CA   . ALA A 1 129 ? -16.60785 -22.22881 20.28581  1.000 35.08446  ? 129 ALA A CA   1 
ATOM   1985 C C    . ALA A 1 129 ? -17.50083 -22.20418 19.06270  1.000 26.53280  ? 129 ALA A C    1 
ATOM   1986 O O    . ALA A 1 129 ? -17.12957 -21.62768 18.03164  1.000 30.78831  ? 129 ALA A O    1 
ATOM   1987 C CB   . ALA A 1 129 ? -16.69515 -20.87721 20.98365  1.000 35.67817  ? 129 ALA A CB   1 
ATOM   1988 H H    . ALA A 1 129 ? -14.84432 -21.84757 19.51818  1.000 35.86620  ? 129 ALA A H    1 
ATOM   1989 H HA   . ALA A 1 129 ? -16.91056 -22.91277 20.90344  1.000 42.15546  ? 129 ALA A HA   1 
ATOM   1990 H HB1  . ALA A 1 129 ? -17.60736 -20.73337 21.28044  1.000 42.86790  ? 129 ALA A HB1  1 
ATOM   1991 H HB2  . ALA A 1 129 ? -16.09523 -20.87601 21.74588  1.000 42.86790  ? 129 ALA A HB2  1 
ATOM   1992 H HB3  . ALA A 1 129 ? -16.43714 -20.18181 20.35854  1.000 42.86790  ? 129 ALA A HB3  1 
ATOM   1993 N N    . MET A 1 130 ? -18.69341 -22.78402 19.19239  1.000 27.31141  ? 130 MET A N    1 
ATOM   1994 C CA   . MET A 1 130 ? -19.74260 -22.57086 18.19654  1.000 27.40567  ? 130 MET A CA   1 
ATOM   1995 C C    . MET A 1 130 ? -20.27920 -21.16749 18.40163  1.000 35.94772  ? 130 MET A C    1 
ATOM   1996 O O    . MET A 1 130 ? -20.90289 -20.89930 19.44109  1.000 32.87703  ? 130 MET A O    1 
ATOM   1997 C CB   . MET A 1 130 ? -20.84442 -23.59169 18.36056  1.000 28.59281  ? 130 MET A CB   1 
ATOM   1998 C CG   . MET A 1 130 ? -22.01740 -23.49455 17.38776  1.000 30.08337  ? 130 MET A CG   1 
ATOM   1999 S SD   . MET A 1 130 ? -21.44935 -23.65440 15.69784  1.000 31.18495  ? 130 MET A SD   1 
ATOM   2000 C CE   . MET A 1 130 ? -20.87785 -25.33203 15.67369  1.000 29.15204  ? 130 MET A CE   1 
ATOM   2001 H H    . MET A 1 130 ? -18.91779 -23.30068 19.84225  1.000 32.82779  ? 130 MET A H    1 
ATOM   2002 H HA   . MET A 1 130 ? -19.38093 -22.67840 17.30294  1.000 32.94090  ? 130 MET A HA   1 
ATOM   2003 H HB2  . MET A 1 130 ? -20.45607 -24.47363 18.24976  1.000 34.36547  ? 130 MET A HB2  1 
ATOM   2004 H HB3  . MET A 1 130 ? -21.20888 -23.49963 19.25476  1.000 34.36547  ? 130 MET A HB3  1 
ATOM   2005 H HG2  . MET A 1 130 ? -22.64967 -24.20725 17.56995  1.000 36.15414  ? 130 MET A HG2  1 
ATOM   2006 H HG3  . MET A 1 130 ? -22.45111 -22.63269 17.48776  1.000 36.15414  ? 130 MET A HG3  1 
ATOM   2007 H HE1  . MET A 1 130 ? -20.66403 -25.57970 14.76054  1.000 35.03655  ? 130 MET A HE1  1 
ATOM   2008 H HE2  . MET A 1 130 ? -20.08645 -25.40409 16.22992  1.000 35.03655  ? 130 MET A HE2  1 
ATOM   2009 H HE3  . MET A 1 130 ? -21.57761 -25.90901 16.01770  1.000 35.03655  ? 130 MET A HE3  1 
ATOM   2010 N N    . ARG A 1 131 ? -20.00295 -20.28031 17.45707  1.000 32.61970  ? 131 ARG A N    1 
ATOM   2011 C CA   . ARG A 1 131 ? -20.33762 -18.86749 17.62964  1.000 29.36847  ? 131 ARG A CA   1 
ATOM   2012 C C    . ARG A 1 131 ? -21.83496 -18.67895 17.47207  1.000 31.83881  ? 131 ARG A C    1 
ATOM   2013 O O    . ARG A 1 131 ? -22.52215 -19.54836 16.93202  1.000 27.98314  ? 131 ARG A O    1 
ATOM   2014 C CB   . ARG A 1 131 ? -19.54183 -18.01889 16.64533  1.000 31.98432  ? 131 ARG A CB   1 
ATOM   2015 C CG   . ARG A 1 131 ? -18.03690 -18.25910 16.89842  1.000 38.11783  ? 131 ARG A CG   1 
ATOM   2016 C CD   . ARG A 1 131 ? -17.16028 -17.07960 16.61715  1.000 38.08496  ? 131 ARG A CD   1 
ATOM   2017 N NE   . ARG A 1 131 ? -17.67282 -15.88276 17.27122  1.000 38.83408  ? 131 ARG A NE   1 
ATOM   2018 C CZ   . ARG A 1 131 ? -17.43975 -15.54821 18.52974  1.000 42.49452  ? 131 ARG A CZ   1 
ATOM   2019 N NH1  . ARG A 1 131 ? -16.64226 -16.27545 19.30830  1.000 32.57510  ? 131 ARG A NH1  1 
ATOM   2020 N NH2  . ARG A 1 131 ? -18.01745 -14.45541 19.01997  1.000 35.02030  ? 131 ARG A NH2  1 
ATOM   2021 H H    . ARG A 1 131 ? -19.62343 -20.46586 16.70798  1.000 39.19774  ? 131 ARG A H    1 
ATOM   2022 H HA   . ARG A 1 131 ? -20.10007 -18.55687 18.51732  1.000 35.29626  ? 131 ARG A HA   1 
ATOM   2023 H HB2  . ARG A 1 131 ? -19.75675 -18.27659 15.73522  1.000 38.43528  ? 131 ARG A HB2  1 
ATOM   2024 H HB3  . ARG A 1 131 ? -19.74133 -17.07923 16.77996  1.000 38.43528  ? 131 ARG A HB3  1 
ATOM   2025 H HG2  . ARG A 1 131 ? -17.91438 -18.49743 17.83067  1.000 45.79550  ? 131 ARG A HG2  1 
ATOM   2026 H HG3  . ARG A 1 131 ? -17.73965 -18.98552 16.32845  1.000 45.79550  ? 131 ARG A HG3  1 
ATOM   2027 H HD2  . ARG A 1 131 ? -16.26657 -17.25395 16.95150  1.000 45.75606  ? 131 ARG A HD2  1 
ATOM   2028 H HD3  . ARG A 1 131 ? -17.13131 -16.91901 15.66098  1.000 45.75606  ? 131 ARG A HD3  1 
ATOM   2029 H HE   . ARG A 1 131 ? -18.16402 -15.35379 16.80377  1.000 46.65500  ? 131 ARG A HE   1 
ATOM   2030 H HH11 . ARG A 1 131 ? -16.26409 -16.98191 18.99605  1.000 39.14422  ? 131 ARG A HH11 1 
ATOM   2031 H HH12 . ARG A 1 131 ? -16.50506 -16.03895 20.12369  1.000 39.14422  ? 131 ARG A HH12 1 
ATOM   2032 H HH21 . ARG A 1 131 ? -18.53202 -13.98030 18.52087  1.000 42.07846  ? 131 ARG A HH21 1 
ATOM   2033 H HH22 . ARG A 1 131 ? -17.87651 -14.22377 19.83610  1.000 42.07846  ? 131 ARG A HH22 1 
ATOM   2034 N N    . PRO A 1 132 ? -22.36600 -17.57281 17.99181  1.000 29.17943  ? 132 PRO A N    1 
ATOM   2035 C CA   . PRO A 1 132 ? -23.80653 -17.30568 17.81986  1.000 29.79938  ? 132 PRO A CA   1 
ATOM   2036 C C    . PRO A 1 132 ? -24.28168 -17.39285 16.38539  1.000 32.96298  ? 132 PRO A C    1 
ATOM   2037 O O    . PRO A 1 132 ? -25.45343 -17.73636 16.14043  1.000 32.95577  ? 132 PRO A O    1 
ATOM   2038 C CB   . PRO A 1 132 ? -23.94737 -15.88866 18.38821  1.000 31.87202  ? 132 PRO A CB   1 
ATOM   2039 C CG   . PRO A 1 132 ? -22.92089 -15.84673 19.48845  1.000 34.19920  ? 132 PRO A CG   1 
ATOM   2040 C CD   . PRO A 1 132 ? -21.71758 -16.56945 18.86506  1.000 29.07491  ? 132 PRO A CD   1 
ATOM   2041 H HA   . PRO A 1 132 ? -24.32792 -17.92469 18.35454  1.000 35.81336  ? 132 PRO A HA   1 
ATOM   2042 H HB2  . PRO A 1 132 ? -23.75540 -15.23067 17.70184  1.000 38.30053  ? 132 PRO A HB2  1 
ATOM   2043 H HB3  . PRO A 1 132 ? -24.84268 -15.75358 18.73615  1.000 38.30053  ? 132 PRO A HB3  1 
ATOM   2044 H HG2  . PRO A 1 132 ? -22.70416 -14.92873 19.71477  1.000 41.09314  ? 132 PRO A HG2  1 
ATOM   2045 H HG3  . PRO A 1 132 ? -23.24660 -16.31395 20.27364  1.000 41.09314  ? 132 PRO A HG3  1 
ATOM   2046 H HD2  . PRO A 1 132 ? -21.17301 -15.95640 18.34687  1.000 34.94400  ? 132 PRO A HD2  1 
ATOM   2047 H HD3  . PRO A 1 132 ? -21.17704 -16.99820 19.54689  1.000 34.94400  ? 132 PRO A HD3  1 
ATOM   2048 N N    . ASN A 1 133 ? -23.41557 -17.11264 15.42312  1.000 31.18234  ? 133 ASN A N    1 
ATOM   2049 C CA   . ASN A 1 133 ? -23.81677 -17.17807 14.02334  1.000 28.78851  ? 133 ASN A CA   1 
ATOM   2050 C C    . ASN A 1 133 ? -23.46744 -18.50971 13.37397  1.000 28.97105  ? 133 ASN A C    1 
ATOM   2051 O O    . ASN A 1 133 ? -23.33178 -18.57341 12.15183  1.000 28.77388  ? 133 ASN A O    1 
ATOM   2052 C CB   . ASN A 1 133 ? -23.21930 -16.04763 13.22856  1.000 25.54720  ? 133 ASN A CB   1 
ATOM   2053 C CG   . ASN A 1 133 ? -21.71187 -16.16710 13.04385  1.000 36.03023  ? 133 ASN A CG   1 
ATOM   2054 O OD1  . ASN A 1 133 ? -21.05656 -17.05476 13.60245  1.000 30.80624  ? 133 ASN A OD1  1 
ATOM   2055 N ND2  . ASN A 1 133 ? -21.15722 -15.27415 12.26299  1.000 31.80456  ? 133 ASN A ND2  1 
ATOM   2056 H H    . ASN A 1 133 ? -22.59682 -16.88403 15.55346  1.000 37.47291  ? 133 ASN A H    1 
ATOM   2057 H HA   . ASN A 1 133 ? -24.78073 -17.07344 13.99620  1.000 34.60031  ? 133 ASN A HA   1 
ATOM   2058 H HB2  . ASN A 1 133 ? -23.62627 -16.03406 12.34817  1.000 30.71074  ? 133 ASN A HB2  1 
ATOM   2059 H HB3  . ASN A 1 133 ? -23.39686 -15.21257 13.68904  1.000 30.71074  ? 133 ASN A HB3  1 
ATOM   2060 H HD21 . ASN A 1 133 ? -20.30899 -15.29331 12.12249  1.000 38.21957  ? 133 ASN A HD21 1 
ATOM   2061 H HD22 . ASN A 1 133 ? -21.64118 -14.66854 11.89068  1.000 38.21957  ? 133 ASN A HD22 1 
ATOM   2062 N N    . PHE A 1 134 ? -23.22322 -19.52936 14.19138  1.000 28.47111  ? 134 PHE A N    1 
ATOM   2063 C CA   . PHE A 1 134 ? -23.00606 -20.92168 13.75747  1.000 29.64598  ? 134 PHE A CA   1 
ATOM   2064 C C    . PHE A 1 134 ? -21.78841 -21.08084 12.85318  1.000 32.53110  ? 134 PHE A C    1 
ATOM   2065 O O    . PHE A 1 134 ? -21.75716 -21.96209 11.96825  1.000 30.75697  ? 134 PHE A O    1 
ATOM   2066 C CB   . PHE A 1 134 ? -24.28122 -21.48752 13.11986  1.000 29.25615  ? 134 PHE A CB   1 
ATOM   2067 C CG   . PHE A 1 134 ? -25.42692 -21.60452 14.09642  1.000 29.89904  ? 134 PHE A CG   1 
ATOM   2068 C CD1  . PHE A 1 134 ? -25.38168 -22.55385 15.11221  1.000 32.77321  ? 134 PHE A CD1  1 
ATOM   2069 C CD2  . PHE A 1 134 ? -26.50395 -20.72440 14.03614  1.000 33.60272  ? 134 PHE A CD2  1 
ATOM   2070 C CE1  . PHE A 1 134 ? -26.40876 -22.66093 16.03668  1.000 36.90172  ? 134 PHE A CE1  1 
ATOM   2071 C CE2  . PHE A 1 134 ? -27.54206 -20.82067 14.94623  1.000 33.16470  ? 134 PHE A CE2  1 
ATOM   2072 C CZ   . PHE A 1 134 ? -27.50508 -21.77896 15.94677  1.000 39.51576  ? 134 PHE A CZ   1 
ATOM   2073 H H    . PHE A 1 134 ? -23.17445 -19.44388 15.04573  1.000 34.21943  ? 134 PHE A H    1 
ATOM   2074 H HA   . PHE A 1 134 ? -22.80388 -21.45953 14.53897  1.000 35.62928  ? 134 PHE A HA   1 
ATOM   2075 H HB2  . PHE A 1 134 ? -24.56039 -20.90054 12.39985  1.000 35.16148  ? 134 PHE A HB2  1 
ATOM   2076 H HB3  . PHE A 1 134 ? -24.09294 -22.37314 12.77182  1.000 35.16148  ? 134 PHE A HB3  1 
ATOM   2077 H HD1  . PHE A 1 134 ? -24.65071 -23.12571 15.17194  1.000 39.38196  ? 134 PHE A HD1  1 
ATOM   2078 H HD2  . PHE A 1 134 ? -26.52597 -20.06659 13.37910  1.000 40.37736  ? 134 PHE A HD2  1 
ATOM   2079 H HE1  . PHE A 1 134 ? -26.37527 -23.30517 16.70655  1.000 44.33616  ? 134 PHE A HE1  1 
ATOM   2080 H HE2  . PHE A 1 134 ? -28.26656 -20.24066 14.88625  1.000 39.85174  ? 134 PHE A HE2  1 
ATOM   2081 H HZ   . PHE A 1 134 ? -28.20293 -21.84020 16.55846  1.000 47.47302  ? 134 PHE A HZ   1 
ATOM   2082 N N    . THR A 1 135 ? -20.75230 -20.28555 13.11496  1.000 32.93623  ? 135 THR A N    1 
ATOM   2083 C CA   . THR A 1 135 ? -19.44414 -20.49298 12.52601  1.000 29.19581  ? 135 THR A CA   1 
ATOM   2084 C C    . THR A 1 135 ? -18.43519 -20.77752 13.63276  1.000 33.03770  ? 135 THR A C    1 
ATOM   2085 O O    . THR A 1 135 ? -18.71020 -20.54858 14.83048  1.000 29.04563  ? 135 THR A O    1 
ATOM   2086 C CB   . THR A 1 135 ? -18.92448 -19.27829 11.73368  1.000 34.94460  ? 135 THR A CB   1 
ATOM   2087 O OG1  . THR A 1 135 ? -18.66862 -18.19436 12.64402  1.000 32.10002  ? 135 THR A OG1  1 
ATOM   2088 C CG2  . THR A 1 135 ? -19.91631 -18.86802 10.66544  1.000 33.51870  ? 135 THR A CG2  1 
ATOM   2089 H H    . THR A 1 135 ? -20.78978 -19.60715 13.64218  1.000 39.57757  ? 135 THR A H    1 
ATOM   2090 H HA   . THR A 1 135 ? -19.51758 -21.24268 11.91490  1.000 35.08908  ? 135 THR A HA   1 
ATOM   2091 H HB   . THR A 1 135 ? -18.09803 -19.50450 11.27903  1.000 41.98762  ? 135 THR A HB   1 
ATOM   2092 H HG1  . THR A 1 135 ? -19.27494 -18.15723 13.22418  1.000 38.57412  ? 135 THR A HG1  1 
ATOM   2093 H HG21 . THR A 1 135 ? -19.51853 -18.20402 10.08083  1.000 40.27654  ? 135 THR A HG21 1 
ATOM   2094 H HG22 . THR A 1 135 ? -20.17265 -19.63981 10.13673  1.000 40.27654  ? 135 THR A HG22 1 
ATOM   2095 H HG23 . THR A 1 135 ? -20.70962 -18.49059 11.07666  1.000 40.27654  ? 135 THR A HG23 1 
ATOM   2096 N N    . ILE A 1 136 ? -17.28279 -21.31198 13.22943  1.000 30.67331  ? 136 ILE A N    1 
ATOM   2097 C CA   . ILE A 1 136 ? -16.16808 -21.48989 14.15094  1.000 28.11354  ? 136 ILE A CA   1 
ATOM   2098 C C    . ILE A 1 136 ? -14.92496 -20.92445 13.48001  1.000 29.23380  ? 136 ILE A C    1 
ATOM   2099 O O    . ILE A 1 136 ? -14.84285 -20.81359 12.25459  1.000 28.43885  ? 136 ILE A O    1 
ATOM   2100 C CB   . ILE A 1 136 ? -15.94334 -22.96742 14.56970  1.000 31.66462  ? 136 ILE A CB   1 
ATOM   2101 C CG1  . ILE A 1 136 ? -15.33149 -23.78715 13.42914  1.000 29.75666  ? 136 ILE A CG1  1 
ATOM   2102 C CG2  . ILE A 1 136 ? -17.25566 -23.57032 15.09134  1.000 30.01086  ? 136 ILE A CG2  1 
ATOM   2103 C CD1  . ILE A 1 136 ? -15.04593 -25.21707 13.81967  1.000 32.05543  ? 136 ILE A CD1  1 
ATOM   2104 H H    . ILE A 1 136 ? -17.12562 -21.57812 12.42689  1.000 36.86208  ? 136 ILE A H    1 
ATOM   2105 H HA   . ILE A 1 136 ? -16.35047 -20.99610 14.96569  1.000 33.79034  ? 136 ILE A HA   1 
ATOM   2106 H HB   . ILE A 1 136 ? -15.29783 -22.99052 15.29336  1.000 38.05164  ? 136 ILE A HB   1 
ATOM   2107 H HG12 . ILE A 1 136 ? -15.95025 -23.79852 12.68221  1.000 35.76209  ? 136 ILE A HG12 1 
ATOM   2108 H HG13 . ILE A 1 136 ? -14.49447 -23.37720 13.16035  1.000 35.76209  ? 136 ILE A HG13 1 
ATOM   2109 H HG21 . ILE A 1 136 ? -17.09029 -24.47952 15.38613  1.000 36.06713  ? 136 ILE A HG21 1 
ATOM   2110 H HG22 . ILE A 1 136 ? -17.57594 -23.03487 15.83404  1.000 36.06713  ? 136 ILE A HG22 1 
ATOM   2111 H HG23 . ILE A 1 136 ? -17.91044 -23.56856 14.37569  1.000 36.06713  ? 136 ILE A HG23 1 
ATOM   2112 H HD11 . ILE A 1 136 ? -15.88296 -25.70512 13.86544  1.000 38.52062  ? 136 ILE A HD11 1 
ATOM   2113 H HD12 . ILE A 1 136 ? -14.46601 -25.61680 13.15273  1.000 38.52062  ? 136 ILE A HD12 1 
ATOM   2114 H HD13 . ILE A 1 136 ? -14.60961 -25.22673 14.68594  1.000 38.52062  ? 136 ILE A HD13 1 
ATOM   2115 N N    . LYS A 1 137 ? -13.96650 -20.51799 14.30619  1.000 29.94005  ? 137 LYS A N    1 
ATOM   2116 C CA   . LYS A 1 137 ? -12.71423 -19.92420 13.87952  1.000 32.34814  ? 137 LYS A CA   1 
ATOM   2117 C C    . LYS A 1 137 ? -11.63899 -20.98106 14.08628  1.000 33.38005  ? 137 LYS A C    1 
ATOM   2118 O O    . LYS A 1 137 ? -11.05901 -21.10236 15.17469  1.000 31.06854  ? 137 LYS A O    1 
ATOM   2119 C CB   . LYS A 1 137 ? -12.43868 -18.64394 14.66993  1.000 37.52204  ? 137 LYS A CB   1 
ATOM   2120 C CG   . LYS A 1 137 ? -13.48703 -17.58821 14.40161  1.000 44.96080  ? 137 LYS A CG   1 
ATOM   2121 C CD   . LYS A 1 137 ? -13.24056 -16.32459 15.22303  1.000 61.18238  ? 137 LYS A CD   1 
ATOM   2122 C CE   . LYS A 1 137 ? -13.88108 -15.09860 14.57211  1.000 66.70061  ? 137 LYS A CE   1 
ATOM   2123 N NZ   . LYS A 1 137 ? -15.31091 -14.91220 14.93550  1.000 58.18323  ? 137 LYS A NZ   1 
ATOM   2124 H H    . LYS A 1 137 ? -14.02640 -20.58119 15.16177  1.000 35.98216  ? 137 LYS A H    1 
ATOM   2125 H HA   . LYS A 1 137 ? -12.74226 -19.69462 12.93749  1.000 38.87187  ? 137 LYS A HA   1 
ATOM   2126 H HB2  . LYS A 1 137 ? -12.44453 -18.84588 15.61866  1.000 45.08055  ? 137 LYS A HB2  1 
ATOM   2127 H HB3  . LYS A 1 137 ? -11.57399 -18.28815 14.41180  1.000 45.08055  ? 137 LYS A HB3  1 
ATOM   2128 H HG2  . LYS A 1 137 ? -13.46709 -17.34845 13.46192  1.000 54.00706  ? 137 LYS A HG2  1 
ATOM   2129 H HG3  . LYS A 1 137 ? -14.36095 -17.93756 14.63639  1.000 54.00706  ? 137 LYS A HG3  1 
ATOM   2130 H HD2  . LYS A 1 137 ? -13.62457 -16.43598 16.10679  1.000 73.47296  ? 137 LYS A HD2  1 
ATOM   2131 H HD3  . LYS A 1 137 ? -12.28581 -16.16839 15.29344  1.000 73.47296  ? 137 LYS A HD3  1 
ATOM   2132 H HE2  . LYS A 1 137 ? -13.39794 -14.30601 14.85369  1.000 80.09484  ? 137 LYS A HE2  1 
ATOM   2133 H HE3  . LYS A 1 137 ? -13.83017 -15.19316 13.60808  1.000 80.09484  ? 137 LYS A HE3  1 
ATOM   2134 H HZ1  . LYS A 1 137 ? -15.39462 -14.84898 15.81929  1.000 69.87398  ? 137 LYS A HZ1  1 
ATOM   2135 H HZ2  . LYS A 1 137 ? -15.62552 -14.16833 14.56162  1.000 69.87398  ? 137 LYS A HZ2  1 
ATOM   2136 H HZ3  . LYS A 1 137 ? -15.79065 -15.60481 14.64873  1.000 69.87398  ? 137 LYS A HZ3  1 
ATOM   2137 N N    . GLY A 1 138 ? -11.40294 -21.75532 13.04113  1.000 31.83007  ? 138 GLY A N    1 
ATOM   2138 C CA   . GLY A 1 138 ? -10.48929 -22.86731 13.15682  1.000 36.01816  ? 138 GLY A CA   1 
ATOM   2139 C C    . GLY A 1 138 ? -9.27473  -22.68313 12.28264  1.000 33.89216  ? 138 GLY A C    1 
ATOM   2140 O O    . GLY A 1 138 ? -8.87789  -21.54888 11.93436  1.000 31.51787  ? 138 GLY A O    1 
ATOM   2141 H H    . GLY A 1 138 ? -11.75720 -21.65595 12.26381  1.000 38.25018  ? 138 GLY A H    1 
ATOM   2142 H HA2  . GLY A 1 138 ? -10.19707 -22.95164 14.07790  1.000 43.27589  ? 138 GLY A HA2  1 
ATOM   2143 H HA3  . GLY A 1 138 ? -10.93931 -23.68484 12.89217  1.000 43.27589  ? 138 GLY A HA3  1 
ATOM   2144 N N    . SER A 1 139 ? -8.65868  -23.82041 11.97652  1.000 30.56831  ? 139 SER A N    1 
ATOM   2145 C CA   . SER A 1 139 ? -7.48399  -23.95535 11.11481  1.000 27.10414  ? 139 SER A CA   1 
ATOM   2146 C C    . SER A 1 139 ? -7.71172  -25.21970 10.28859  1.000 30.85785  ? 139 SER A C    1 
ATOM   2147 O O    . SER A 1 139 ? -7.52620  -26.33250 10.79095  1.000 29.25856  ? 139 SER A O    1 
ATOM   2148 C CB   . SER A 1 139 ? -6.19735  -24.05134 11.91942  1.000 31.20404  ? 139 SER A CB   1 
ATOM   2149 O OG   . SER A 1 139 ? -5.06595  -24.11189 11.07134  1.000 33.42798  ? 139 SER A OG   1 
ATOM   2150 H H    . SER A 1 139 ? -8.91922  -24.58331 12.27601  1.000 36.73607  ? 139 SER A H    1 
ATOM   2151 H HA   . SER A 1 139 ? -7.41016  -23.18375 10.53164  1.000 32.57907  ? 139 SER A HA   1 
ATOM   2152 H HB2  . SER A 1 139 ? -6.12278  -23.26855 12.48739  1.000 37.49895  ? 139 SER A HB2  1 
ATOM   2153 H HB3  . SER A 1 139 ? -6.22587  -24.85417 12.46307  1.000 37.49895  ? 139 SER A HB3  1 
ATOM   2154 H HG   . SER A 1 139 ? -4.37137  -24.23528 11.52733  1.000 40.16768  ? 139 SER A HG   1 
ATOM   2155 N N    . PHE A 1 140 ? -8.10217  -25.05512 9.03019   1.000 28.62264  ? 140 PHE A N    1 
ATOM   2156 C CA   . PHE A 1 140 ? -8.49150  -26.16100 8.18616   1.000 28.08214  ? 140 PHE A CA   1 
ATOM   2157 C C    . PHE A 1 140 ? -7.96593  -25.92528 6.77616   1.000 29.46369  ? 140 PHE A C    1 
ATOM   2158 O O    . PHE A 1 140 ? -8.14961  -24.82813 6.22239   1.000 32.40626  ? 140 PHE A O    1 
ATOM   2159 C CB   . PHE A 1 140 ? -10.01315 -26.32462 8.08881   1.000 28.83102  ? 140 PHE A CB   1 
ATOM   2160 C CG   . PHE A 1 140 ? -10.70389 -26.70403 9.36068   1.000 30.18997  ? 140 PHE A CG   1 
ATOM   2161 C CD1  . PHE A 1 140 ? -10.71900 -28.00326 9.83426   1.000 31.54509  ? 140 PHE A CD1  1 
ATOM   2162 C CD2  . PHE A 1 140 ? -11.41168 -25.75010 10.05646  1.000 32.37967  ? 140 PHE A CD2  1 
ATOM   2163 C CE1  . PHE A 1 140 ? -11.40413 -28.31195 10.99968  1.000 25.73640  ? 140 PHE A CE1  1 
ATOM   2164 C CE2  . PHE A 1 140 ? -12.10068 -26.04961 11.19973  1.000 29.19326  ? 140 PHE A CE2  1 
ATOM   2165 C CZ   . PHE A 1 140 ? -12.12437 -27.26298 11.67579  1.000 24.29937  ? 140 PHE A CZ   1 
ATOM   2166 H H    . PHE A 1 140 ? -8.14896  -24.29089 8.63857   1.000 34.40127  ? 140 PHE A H    1 
ATOM   2167 H HA   . PHE A 1 140 ? -8.10682  -26.96691 8.56487   1.000 33.75267  ? 140 PHE A HA   1 
ATOM   2168 H HB2  . PHE A 1 140 ? -10.39234 -25.48150 7.79511   1.000 34.65133  ? 140 PHE A HB2  1 
ATOM   2169 H HB3  . PHE A 1 140 ? -10.20424 -27.01871 7.43871   1.000 34.65133  ? 140 PHE A HB3  1 
ATOM   2170 H HD1  . PHE A 1 140 ? -10.26861 -28.67151 9.37005   1.000 37.90821  ? 140 PHE A HD1  1 
ATOM   2171 H HD2  . PHE A 1 140 ? -11.42176 -24.87574 9.73977   1.000 38.90971  ? 140 PHE A HD2  1 
ATOM   2172 H HE1  . PHE A 1 140 ? -11.39888 -29.17823 11.33796  1.000 30.93779  ? 140 PHE A HE1  1 
ATOM   2173 H HE2  . PHE A 1 140 ? -12.56057 -25.37528 11.64548  1.000 35.08601  ? 140 PHE A HE2  1 
ATOM   2174 H HZ   . PHE A 1 140 ? -12.60477 -27.45102 12.44959  1.000 29.21335  ? 140 PHE A HZ   1 
ATOM   2175 N N    . LEU A 1 141 ? -7.29762  -26.91683 6.22529   1.000 29.47638  ? 141 LEU A N    1 
ATOM   2176 C CA   . LEU A 1 141 ? -6.82427  -26.86794 4.84640   1.000 30.54172  ? 141 LEU A CA   1 
ATOM   2177 C C    . LEU A 1 141 ? -7.57346  -27.86198 3.97935   1.000 34.08254  ? 141 LEU A C    1 
ATOM   2178 O O    . LEU A 1 141 ? -8.38541  -28.67306 4.43201   1.000 32.17678  ? 141 LEU A O    1 
ATOM   2179 C CB   . LEU A 1 141 ? -5.32417  -27.15262 4.78125   1.000 31.73055  ? 141 LEU A CB   1 
ATOM   2180 C CG   . LEU A 1 141 ? -4.47163  -26.13113 5.52549   1.000 34.69348  ? 141 LEU A CG   1 
ATOM   2181 C CD1  . LEU A 1 141 ? -3.04038  -26.62331 5.62532   1.000 41.37914  ? 141 LEU A CD1  1 
ATOM   2182 C CD2  . LEU A 1 141 ? -4.54234  -24.76156 4.87283   1.000 41.73015  ? 141 LEU A CD2  1 
ATOM   2183 H H    . LEU A 1 141 ? -7.09881  -27.64687 6.63409   1.000 35.42576  ? 141 LEU A H    1 
ATOM   2184 H HA   . LEU A 1 141 ? -6.99151  -25.97894 4.49624   1.000 36.70417  ? 141 LEU A HA   1 
ATOM   2185 H HB2  . LEU A 1 141 ? -5.15535  -28.02299 5.17476   1.000 38.13076  ? 141 LEU A HB2  1 
ATOM   2186 H HB3  . LEU A 1 141 ? -5.04704  -27.14942 3.85168   1.000 38.13076  ? 141 LEU A HB3  1 
ATOM   2187 H HG   . LEU A 1 141 ? -4.82008  -26.02664 6.42469   1.000 41.68628  ? 141 LEU A HG   1 
ATOM   2188 H HD11 . LEU A 1 141 ? -3.04587  -27.57975 5.78686   1.000 49.70907  ? 141 LEU A HD11 1 
ATOM   2189 H HD12 . LEU A 1 141 ? -2.58153  -26.43112 4.79260   1.000 49.70907  ? 141 LEU A HD12 1 
ATOM   2190 H HD13 . LEU A 1 141 ? -2.59977  -26.16649 6.35886   1.000 49.70907  ? 141 LEU A HD13 1 
ATOM   2191 H HD21 . LEU A 1 141 ? -5.47249  -24.53089 4.72277   1.000 50.13028  ? 141 LEU A HD21 1 
ATOM   2192 H HD22 . LEU A 1 141 ? -4.13066  -24.10963 5.46138   1.000 50.13028  ? 141 LEU A HD22 1 
ATOM   2193 H HD23 . LEU A 1 141 ? -4.06799  -24.78985 4.02720   1.000 50.13028  ? 141 LEU A HD23 1 
ATOM   2194 N N    . ASN A 1 142 ? -7.27777  -27.80304 2.68501   1.000 35.69277  ? 142 ASN A N    1 
ATOM   2195 C CA   . ASN A 1 142 ? -7.75172  -28.85631 1.81087   1.000 36.49641  ? 142 ASN A CA   1 
ATOM   2196 C C    . ASN A 1 142 ? -7.44587  -30.22630 2.40215   1.000 32.05552  ? 142 ASN A C    1 
ATOM   2197 O O    . ASN A 1 142 ? -6.34144  -30.47712 2.89160   1.000 38.04758  ? 142 ASN A O    1 
ATOM   2198 C CB   . ASN A 1 142 ? -7.09457  -28.69990 0.44547   1.000 39.01640  ? 142 ASN A CB   1 
ATOM   2199 C CG   . ASN A 1 142 ? -8.07936  -28.76117 -0.63550  1.000 53.25243  ? 142 ASN A CG   1 
ATOM   2200 O OD1  . ASN A 1 142 ? -8.66452  -27.73539 -1.01013  1.000 62.61626  ? 142 ASN A OD1  1 
ATOM   2201 N ND2  . ASN A 1 142 ? -8.34128  -29.97537 -1.12456  1.000 59.06088  ? 142 ASN A ND2  1 
ATOM   2202 H H    . ASN A 1 142 ? -6.81922  -27.18246 2.30527   1.000 42.88542  ? 142 ASN A H    1 
ATOM   2203 H HA   . ASN A 1 142 ? -8.71338  -28.79091 1.70213   1.000 43.84979  ? 142 ASN A HA   1 
ATOM   2204 H HB2  . ASN A 1 142 ? -6.64666  -27.84063 0.40168   1.000 46.87378  ? 142 ASN A HB2  1 
ATOM   2205 H HB3  . ASN A 1 142 ? -6.45298  -29.41552 0.31449   1.000 46.87378  ? 142 ASN A HB3  1 
ATOM   2206 H HD21 . ASN A 1 142 ? -8.91218  -30.06866 -1.76093  1.000 70.92715  ? 142 ASN A HD21 1 
ATOM   2207 H HD22 . ASN A 1 142 ? -7.93912  -30.66430 -0.80325  1.000 70.92715  ? 142 ASN A HD22 1 
ATOM   2208 N N    . GLY A 1 143 ? -8.44015  -31.10918 2.38245   1.000 31.10465  ? 143 GLY A N    1 
ATOM   2209 C CA   . GLY A 1 143 ? -8.27978  -32.43907 2.88928   1.000 28.99784  ? 143 GLY A CA   1 
ATOM   2210 C C    . GLY A 1 143 ? -8.68311  -32.62764 4.34093   1.000 27.72722  ? 143 GLY A C    1 
ATOM   2211 O O    . GLY A 1 143 ? -8.69430  -33.76326 4.81817   1.000 30.59379  ? 143 GLY A O    1 
ATOM   2212 H H    . GLY A 1 143 ? -9.22552  -30.94578 2.07243   1.000 37.37968  ? 143 GLY A H    1 
ATOM   2213 H HA2  . GLY A 1 143 ? -8.81816  -33.04191 2.35296   1.000 34.85151  ? 143 GLY A HA2  1 
ATOM   2214 H HA3  . GLY A 1 143 ? -7.34674  -32.69130 2.80733   1.000 34.85151  ? 143 GLY A HA3  1 
ATOM   2215 N N    . SER A 1 144 ? -9.04247  -31.54188 5.03082   1.000 29.01605  ? 144 SER A N    1 
ATOM   2216 C CA   . SER A 1 144 ? -9.41223  -31.59289 6.45225   1.000 32.42697  ? 144 SER A CA   1 
ATOM   2217 C C    . SER A 1 144 ? -10.87776 -31.93751 6.69699   1.000 31.05811  ? 144 SER A C    1 
ATOM   2218 O O    . SER A 1 144 ? -11.26229 -32.24201 7.84390   1.000 28.05470  ? 144 SER A O    1 
ATOM   2219 C CB   . SER A 1 144 ? -9.09237  -30.23226 7.08190   1.000 27.52887  ? 144 SER A CB   1 
ATOM   2220 O OG   . SER A 1 144 ? -9.92435  -29.21556 6.54485   1.000 29.97088  ? 144 SER A OG   1 
ATOM   2221 H H    . SER A 1 144 ? -9.08144  -30.75090 4.69552   1.000 34.87336  ? 144 SER A H    1 
ATOM   2222 H HA   . SER A 1 144 ? -8.89079  -32.28282 6.89157   1.000 38.96647  ? 144 SER A HA   1 
ATOM   2223 H HB2  . SER A 1 144 ? -9.23828  -30.28591 8.03936   1.000 33.08875  ? 144 SER A HB2  1 
ATOM   2224 H HB3  . SER A 1 144 ? -8.16586  -30.01049 6.89942   1.000 33.08875  ? 144 SER A HB3  1 
ATOM   2225 H HG   . SER A 1 144 ? -10.73096 -29.39452 6.69637   1.000 36.01915  ? 144 SER A HG   1 
ATOM   2226 N N    . CYS A 1 145 ? -11.70982 -31.94885 5.64956   1.000 27.62891  ? 145 CYS A N    1 
ATOM   2227 C CA   . CYS A 1 145 ? -13.10465 -32.29210 5.85530   1.000 29.58751  ? 145 CYS A CA   1 
ATOM   2228 C C    . CYS A 1 145 ? -13.24499 -33.70074 6.40904   1.000 31.79170  ? 145 CYS A C    1 
ATOM   2229 O O    . CYS A 1 145 ? -12.46845 -34.59438 6.10326   1.000 28.48308  ? 145 CYS A O    1 
ATOM   2230 C CB   . CYS A 1 145 ? -13.86548 -32.12525 4.55658   1.000 29.07488  ? 145 CYS A CB   1 
ATOM   2231 S SG   . CYS A 1 145 ? -14.07113 -30.38826 4.16882   1.000 28.10294  ? 145 CYS A SG   1 
ATOM   2232 H H    . CYS A 1 145 ? -11.49113 -31.76623 4.83812   1.000 33.20879  ? 145 CYS A H    1 
ATOM   2233 H HA   . CYS A 1 145 ? -13.50179 -31.69685 6.51016   1.000 35.55912  ? 145 CYS A HA   1 
ATOM   2234 H HB2  . CYS A 1 145 ? -13.37281 -32.54760 3.83560   1.000 34.94396  ? 145 CYS A HB2  1 
ATOM   2235 H HB3  . CYS A 1 145 ? -14.74294 -32.53013 4.64051   1.000 34.94396  ? 145 CYS A HB3  1 
ATOM   2236 N N    . GLY A 1 146 ? -14.24615 -33.87554 7.27334   1.000 27.09716  ? 146 GLY A N    1 
ATOM   2237 C CA   . GLY A 1 146 ? -14.41358 -35.08264 8.04258   1.000 28.63615  ? 146 GLY A CA   1 
ATOM   2238 C C    . GLY A 1 146 ? -13.74554 -35.06766 9.39763   1.000 26.74735  ? 146 GLY A C    1 
ATOM   2239 O O    . GLY A 1 146 ? -14.06522 -35.91802 10.23213  1.000 28.52957  ? 146 GLY A O    1 
ATOM   2240 H H    . GLY A 1 146 ? -14.85259 -33.28566 7.42786   1.000 32.57070  ? 146 GLY A H    1 
ATOM   2241 H HA2  . GLY A 1 146 ? -15.36160 -35.23389 8.18143   1.000 34.41748  ? 146 GLY A HA2  1 
ATOM   2242 H HA3  . GLY A 1 146 ? -14.04564 -35.82569 7.53920   1.000 34.41748  ? 146 GLY A HA3  1 
ATOM   2243 N N    . SER A 1 147 ? -12.79779 -34.15185 9.61575   1.000 28.66823  ? 147 SER A N    1 
ATOM   2244 C CA   . SER A 1 147 ? -12.33124 -33.87235 10.96437  1.000 24.67628  ? 147 SER A CA   1 
ATOM   2245 C C    . SER A 1 147 ? -13.52832 -33.51813 11.83353  1.000 28.58810  ? 147 SER A C    1 
ATOM   2246 O O    . SER A 1 147 ? -14.47240 -32.86865 11.34500  1.000 27.21270  ? 147 SER A O    1 
ATOM   2247 C CB   . SER A 1 147 ? -11.36111 -32.72181 10.97157  1.000 27.73913  ? 147 SER A CB   1 
ATOM   2248 O OG   . SER A 1 147 ? -10.22488 -32.94487 10.18745  1.000 33.31785  ? 147 SER A OG   1 
ATOM   2249 H H    . SER A 1 147 ? -12.41548 -33.68564 9.00249   1.000 34.45598  ? 147 SER A H    1 
ATOM   2250 H HA   . SER A 1 147 ? -11.87286 -34.65046 11.31840  1.000 29.66564  ? 147 SER A HA   1 
ATOM   2251 H HB2  . SER A 1 147 ? -11.81713 -31.93626 10.63118  1.000 33.34105  ? 147 SER A HB2  1 
ATOM   2252 H HB3  . SER A 1 147 ? -11.07550 -32.56945 11.88597  1.000 33.34105  ? 147 SER A HB3  1 
ATOM   2253 H HG   . SER A 1 147 ? -10.24164 -32.44892 9.50970   1.000 40.03552  ? 147 SER A HG   1 
ATOM   2254 N N    . VAL A 1 148 ? -13.48454 -33.93390 13.11441  1.000 26.23225  ? 148 VAL A N    1 
ATOM   2255 C CA   . VAL A 1 148 ? -14.63806 -33.81426 14.00759  1.000 23.33459  ? 148 VAL A CA   1 
ATOM   2256 C C    . VAL A 1 148 ? -14.31761 -33.01880 15.25054  1.000 24.61761  ? 148 VAL A C    1 
ATOM   2257 O O    . VAL A 1 148 ? -13.15398 -32.83454 15.65336  1.000 25.86555  ? 148 VAL A O    1 
ATOM   2258 C CB   . VAL A 1 148 ? -15.21186 -35.18890 14.42487  1.000 24.99529  ? 148 VAL A CB   1 
ATOM   2259 C CG1  . VAL A 1 148 ? -15.62608 -35.95954 13.19720  1.000 26.54923  ? 148 VAL A CG1  1 
ATOM   2260 C CG2  . VAL A 1 148 ? -14.19444 -35.97023 15.22839  1.000 29.55036  ? 148 VAL A CG2  1 
ATOM   2261 H H    . VAL A 1 148 ? -12.79310 -34.28835 13.48301  1.000 31.53280  ? 148 VAL A H    1 
ATOM   2262 H HA   . VAL A 1 148 ? -15.30236 -33.30968 13.51262  1.000 28.05560  ? 148 VAL A HA   1 
ATOM   2263 H HB   . VAL A 1 148 ? -15.99143 -35.05471 14.98627  1.000 30.04845  ? 148 VAL A HB   1 
ATOM   2264 H HG11 . VAL A 1 148 ? -16.20425 -35.40131 12.65406  1.000 31.91318  ? 148 VAL A HG11 1 
ATOM   2265 H HG12 . VAL A 1 148 ? -14.83301 -36.20230 12.69421  1.000 31.91318  ? 148 VAL A HG12 1 
ATOM   2266 H HG13 . VAL A 1 148 ? -16.10131 -36.75933 13.47180  1.000 31.91318  ? 148 VAL A HG13 1 
ATOM   2267 H HG21 . VAL A 1 148 ? -13.30310 -35.70187 14.95564  1.000 35.51454  ? 148 VAL A HG21 1 
ATOM   2268 H HG22 . VAL A 1 148 ? -14.32316 -35.78038 16.17088  1.000 35.51454  ? 148 VAL A HG22 1 
ATOM   2269 H HG23 . VAL A 1 148 ? -14.32028 -36.91745 15.06157  1.000 35.51454  ? 148 VAL A HG23 1 
ATOM   2270 N N    . GLY A 1 149 ? -15.38758 -32.47223 15.81358  1.000 25.78716  ? 149 GLY A N    1 
ATOM   2271 C CA   . GLY A 1 149 ? -15.33829 -31.76682 17.08294  1.000 27.24341  ? 149 GLY A CA   1 
ATOM   2272 C C    . GLY A 1 149 ? -16.01999 -32.61481 18.13996  1.000 27.77344  ? 149 GLY A C    1 
ATOM   2273 O O    . GLY A 1 149 ? -17.00019 -33.29491 17.86484  1.000 27.25884  ? 149 GLY A O    1 
ATOM   2274 H H    . GLY A 1 149 ? -16.17478 -32.49850 15.46828  1.000 30.99869  ? 149 GLY A H    1 
ATOM   2275 H HA2  . GLY A 1 149 ? -14.41731 -31.60920 17.34341  1.000 32.74619  ? 149 GLY A HA2  1 
ATOM   2276 H HA3  . GLY A 1 149 ? -15.79638 -30.91482 17.01108  1.000 32.74619  ? 149 GLY A HA3  1 
ATOM   2277 N N    . PHE A 1 150 ? -15.52422 -32.52936 19.36446  1.000 27.52030  ? 150 PHE A N    1 
ATOM   2278 C CA   . PHE A 1 150 ? -16.01600 -33.43435 20.39280  1.000 28.69054  ? 150 PHE A CA   1 
ATOM   2279 C C    . PHE A 1 150 ? -15.79439 -32.80766 21.76875  1.000 31.02002  ? 150 PHE A C    1 
ATOM   2280 O O    . PHE A 1 150 ? -14.91792 -31.95092 21.95281  1.000 28.70408  ? 150 PHE A O    1 
ATOM   2281 C CB   . PHE A 1 150 ? -15.32164 -34.77622 20.33653  1.000 27.16737  ? 150 PHE A CB   1 
ATOM   2282 C CG   . PHE A 1 150 ? -13.84457 -34.70176 20.53723  1.000 25.29554  ? 150 PHE A CG   1 
ATOM   2283 C CD1  . PHE A 1 150 ? -13.00831 -34.31816 19.49848  1.000 30.13504  ? 150 PHE A CD1  1 
ATOM   2284 C CD2  . PHE A 1 150 ? -13.29760 -34.94748 21.78337  1.000 29.06998  ? 150 PHE A CD2  1 
ATOM   2285 C CE1  . PHE A 1 150 ? -11.64038 -34.22078 19.68703  1.000 30.59537  ? 150 PHE A CE1  1 
ATOM   2286 C CE2  . PHE A 1 150 ? -11.94234 -34.88130 21.97111  1.000 29.42510  ? 150 PHE A CE2  1 
ATOM   2287 C CZ   . PHE A 1 150 ? -11.10510 -34.49496 20.93179  1.000 29.55033  ? 150 PHE A CZ   1 
ATOM   2288 H H    . PHE A 1 150 ? -14.92011 -31.97257 19.61869  1.000 33.07846  ? 150 PHE A H    1 
ATOM   2289 H HA   . PHE A 1 150 ? -16.96793 -33.56110 20.25614  1.000 34.48275  ? 150 PHE A HA   1 
ATOM   2290 H HB2  . PHE A 1 150 ? -15.68609 -35.34476 21.03283  1.000 32.65495  ? 150 PHE A HB2  1 
ATOM   2291 H HB3  . PHE A 1 150 ? -15.48186 -35.17339 19.46620  1.000 32.65495  ? 150 PHE A HB3  1 
ATOM   2292 H HD1  . PHE A 1 150 ? -13.37160 -34.12394 18.66469  1.000 36.21615  ? 150 PHE A HD1  1 
ATOM   2293 H HD2  . PHE A 1 150 ? -13.85337 -35.15898 22.49841  1.000 34.93808  ? 150 PHE A HD2  1 
ATOM   2294 H HE1  . PHE A 1 150 ? -11.08626 -33.97306 18.98242  1.000 36.76855  ? 150 PHE A HE1  1 
ATOM   2295 H HE2  . PHE A 1 150 ? -11.58004 -35.09649 22.80016  1.000 35.36422  ? 150 PHE A HE2  1 
ATOM   2296 H HZ   . PHE A 1 150 ? -10.18882 -34.42116 21.07284  1.000 35.51450  ? 150 PHE A HZ   1 
ATOM   2297 N N    . ASN A 1 151 ? -16.55427 -33.31797 22.73163  1.000 30.47057  ? 151 ASN A N    1 
ATOM   2298 C CA   . ASN A 1 151 ? -16.33638 -33.13496 24.16322  1.000 35.65906  ? 151 ASN A CA   1 
ATOM   2299 C C    . ASN A 1 151 ? -16.17072 -34.50336 24.82046  1.000 36.90453  ? 151 ASN A C    1 
ATOM   2300 O O    . ASN A 1 151 ? -16.65663 -35.50556 24.31006  1.000 32.00276  ? 151 ASN A O    1 
ATOM   2301 C CB   . ASN A 1 151 ? -17.51393 -32.41049 24.77431  1.000 33.34673  ? 151 ASN A CB   1 
ATOM   2302 C CG   . ASN A 1 151 ? -17.51018 -30.94757 24.45647  1.000 34.54076  ? 151 ASN A CG   1 
ATOM   2303 O OD1  . ASN A 1 151 ? -18.22971 -30.47931 23.58507  1.000 35.36002  ? 151 ASN A OD1  1 
ATOM   2304 N ND2  . ASN A 1 151 ? -16.64906 -30.21815 25.13789  1.000 34.35770  ? 151 ASN A ND2  1 
ATOM   2305 H H    . ASN A 1 151 ? -17.24522 -33.80425 22.57124  1.000 36.61879  ? 151 ASN A H    1 
ATOM   2306 H HA   . ASN A 1 151 ? -15.53174 -32.61826 24.32597  1.000 42.84497  ? 151 ASN A HA   1 
ATOM   2307 H HB2  . ASN A 1 151 ? -18.33590 -32.79214 24.42845  1.000 40.07017  ? 151 ASN A HB2  1 
ATOM   2308 H HB3  . ASN A 1 151 ? -17.48217 -32.50966 25.73870  1.000 40.07017  ? 151 ASN A HB3  1 
ATOM   2309 H HD21 . ASN A 1 151 ? -16.59952 -29.37072 25.00006  1.000 41.28334  ? 151 ASN A HD21 1 
ATOM   2310 H HD22 . ASN A 1 151 ? -16.13683 -30.58975 25.72024  1.000 41.28334  ? 151 ASN A HD22 1 
ATOM   2311 N N    . ILE A 1 152 ? -15.51558 -34.55137 25.98333  1.000 36.92595  ? 152 ILE A N    1 
ATOM   2312 C CA   . ILE A 1 152 ? -15.36630 -35.81030 26.71347  1.000 31.16323  ? 152 ILE A CA   1 
ATOM   2313 C C    . ILE A 1 152 ? -15.86784 -35.59296 28.13360  1.000 44.29458  ? 152 ILE A C    1 
ATOM   2314 O O    . ILE A 1 152 ? -15.53459 -34.58471 28.75947  1.000 41.92048  ? 152 ILE A O    1 
ATOM   2315 C CB   . ILE A 1 152 ? -13.91629 -36.31712 26.70856  1.000 31.09457  ? 152 ILE A CB   1 
ATOM   2316 C CG1  . ILE A 1 152 ? -13.40976 -36.44727 25.26387  1.000 36.90376  ? 152 ILE A CG1  1 
ATOM   2317 C CG2  . ILE A 1 152 ? -13.81320 -37.63462 27.47685  1.000 39.78472  ? 152 ILE A CG2  1 
ATOM   2318 C CD1  . ILE A 1 152 ? -12.02457 -37.06336 25.14286  1.000 42.65164  ? 152 ILE A CD1  1 
ATOM   2319 H H    . ILE A 1 152 ? -15.15218 -33.87184 26.36513  1.000 44.36524  ? 152 ILE A H    1 
ATOM   2320 H HA   . ILE A 1 152 ? -15.91545 -36.49278 26.29687  1.000 37.44998  ? 152 ILE A HA   1 
ATOM   2321 H HB   . ILE A 1 152 ? -13.34914 -35.67293 27.16050  1.000 37.36758  ? 152 ILE A HB   1 
ATOM   2322 H HG12 . ILE A 1 152 ? -14.02603 -37.00907 24.76841  1.000 44.33861  ? 152 ILE A HG12 1 
ATOM   2323 H HG13 . ILE A 1 152 ? -13.37430 -35.56304 24.86666  1.000 44.33861  ? 152 ILE A HG13 1 
ATOM   2324 H HG21 . ILE A 1 152 ? -14.37107 -38.29832 27.04189  1.000 47.79577  ? 152 ILE A HG21 1 
ATOM   2325 H HG22 . ILE A 1 152 ? -12.88878 -37.92846 27.47726  1.000 47.79577  ? 152 ILE A HG22 1 
ATOM   2326 H HG23 . ILE A 1 152 ? -14.11587 -37.49363 28.38757  1.000 47.79577  ? 152 ILE A HG23 1 
ATOM   2327 H HD11 . ILE A 1 152 ? -11.43211 -36.63623 25.78119  1.000 51.23607  ? 152 ILE A HD11 1 
ATOM   2328 H HD12 . ILE A 1 152 ? -12.08386 -38.01313 25.33077  1.000 51.23607  ? 152 ILE A HD12 1 
ATOM   2329 H HD13 . ILE A 1 152 ? -11.69485 -36.92449 24.24126  1.000 51.23607  ? 152 ILE A HD13 1 
ATOM   2330 N N    . ASP A 1 153 ? -16.69694 -36.51833 28.62110  1.000 53.89539  ? 153 ASP A N    1 
ATOM   2331 C CA   . ASP A 1 153 ? -17.18905 -36.53185 29.99842  1.000 51.18315  ? 153 ASP A CA   1 
ATOM   2332 C C    . ASP A 1 153 ? -16.78110 -37.86598 30.61016  1.000 47.03688  ? 153 ASP A C    1 
ATOM   2333 O O    . ASP A 1 153 ? -17.35634 -38.90554 30.27645  1.000 47.99472  ? 153 ASP A O    1 
ATOM   2334 C CB   . ASP A 1 153 ? -18.70336 -36.33594 30.03310  1.000 54.18719  ? 153 ASP A CB   1 
ATOM   2335 C CG   . ASP A 1 153 ? -19.28368 -36.46369 31.43551  1.000 65.86406  ? 153 ASP A CG   1 
ATOM   2336 O OD1  . ASP A 1 153 ? -18.50269 -36.53923 32.41650  1.000 61.03209  ? 153 ASP A OD1  1 
ATOM   2337 O OD2  . ASP A 1 153 ? -20.52806 -36.49044 31.55366  1.000 71.67161  ? 153 ASP A OD2  1 
ATOM   2338 H H    . ASP A 1 153 ? -16.99938 -37.17370 28.15354  1.000 64.72857  ? 153 ASP A H    1 
ATOM   2339 H HA   . ASP A 1 153 ? -16.78386 -35.81604 30.51256  1.000 61.47388  ? 153 ASP A HA   1 
ATOM   2340 H HB2  . ASP A 1 153 ? -18.91483 -35.44947 29.70091  1.000 65.07873  ? 153 ASP A HB2  1 
ATOM   2341 H HB3  . ASP A 1 153 ? -19.12175 -37.00856 29.47326  1.000 65.07873  ? 153 ASP A HB3  1 
ATOM   2342 N N    . TYR A 1 154 ? -15.79214 -37.83246 31.50129  1.000 47.61379  ? 154 TYR A N    1 
ATOM   2343 C CA   . TYR A 1 154 ? -15.10325 -39.02126 31.99390  1.000 49.35337  ? 154 TYR A CA   1 
ATOM   2344 C C    . TYR A 1 154 ? -14.73137 -39.94648 30.83487  1.000 49.42021  ? 154 TYR A C    1 
ATOM   2345 O O    . TYR A 1 154 ? -13.66969 -39.77316 30.22928  1.000 44.44043  ? 154 TYR A O    1 
ATOM   2346 C CB   . TYR A 1 154 ? -15.93007 -39.78329 33.03750  1.000 52.12553  ? 154 TYR A CB   1 
ATOM   2347 C CG   . TYR A 1 154 ? -15.14113 -40.94066 33.64804  1.000 71.46889  ? 154 TYR A CG   1 
ATOM   2348 C CD1  . TYR A 1 154 ? -13.85924 -40.74572 34.16282  1.000 82.25601  ? 154 TYR A CD1  1 
ATOM   2349 C CD2  . TYR A 1 154 ? -15.66466 -42.23010 33.68956  1.000 71.28058  ? 154 TYR A CD2  1 
ATOM   2350 C CE1  . TYR A 1 154 ? -13.12421 -41.80228 34.69977  1.000 76.93870  ? 154 TYR A CE1  1 
ATOM   2351 C CE2  . TYR A 1 154 ? -14.93417 -43.28927 34.23235  1.000 74.00667  ? 154 TYR A CE2  1 
ATOM   2352 C CZ   . TYR A 1 154 ? -13.66593 -43.06574 34.73474  1.000 74.98628  ? 154 TYR A CZ   1 
ATOM   2353 O OH   . TYR A 1 154 ? -12.92878 -44.09902 35.27272  1.000 89.42578  ? 154 TYR A OH   1 
ATOM   2354 H H    . TYR A 1 154 ? -15.49059 -37.10587 31.84875  1.000 57.19065  ? 154 TYR A H    1 
ATOM   2355 H HA   . TYR A 1 154 ? -14.29129 -38.73074 32.43801  1.000 59.27815  ? 154 TYR A HA   1 
ATOM   2356 H HB2  . TYR A 1 154 ? -16.18217 -39.17640 33.75096  1.000 62.60473  ? 154 TYR A HB2  1 
ATOM   2357 H HB3  . TYR A 1 154 ? -16.72402 -40.14551 32.61403  1.000 62.60473  ? 154 TYR A HB3  1 
ATOM   2358 H HD1  . TYR A 1 154 ? -13.48715 -39.89353 34.14761  1.000 98.76131  ? 154 TYR A HD1  1 
ATOM   2359 H HD2  . TYR A 1 154 ? -16.51574 -42.38880 33.34987  1.000 85.59079  ? 154 TYR A HD2  1 
ATOM   2360 H HE1  . TYR A 1 154 ? -12.26918 -41.65264 35.03360  1.000 92.38054  ? 154 TYR A HE1  1 
ATOM   2361 H HE2  . TYR A 1 154 ? -15.30040 -44.14380 34.25581  1.000 88.86211  ? 154 TYR A HE2  1 
ATOM   2362 H HH   . TYR A 1 154 ? -13.40035 -44.53820 35.81156  1.000 107.36504 ? 154 TYR A HH   1 
ATOM   2363 N N    . ASP A 1 155 ? -15.58302 -40.92362 30.50936  1.000 46.30692  ? 155 ASP A N    1 
ATOM   2364 C CA   . ASP A 1 155 ? -15.24144 -41.90320 29.48275  1.000 51.76769  ? 155 ASP A CA   1 
ATOM   2365 C C    . ASP A 1 155 ? -16.08584 -41.81541 28.21617  1.000 45.06314  ? 155 ASP A C    1 
ATOM   2366 O O    . ASP A 1 155 ? -15.82379 -42.57362 27.27340  1.000 43.90045  ? 155 ASP A O    1 
ATOM   2367 C CB   . ASP A 1 155 ? -15.33221 -43.33171 30.06059  1.000 58.95714  ? 155 ASP A CB   1 
ATOM   2368 C CG   . ASP A 1 155 ? -16.71977 -43.67218 30.62102  1.000 58.95878  ? 155 ASP A CG   1 
ATOM   2369 O OD1  . ASP A 1 155 ? -17.65846 -42.86236 30.51044  1.000 52.53078  ? 155 ASP A OD1  1 
ATOM   2370 O OD2  . ASP A 1 155 ? -16.87321 -44.77623 31.19281  1.000 64.72579  ? 155 ASP A OD2  1 
ATOM   2371 H H    . ASP A 1 155 ? -16.35664 -41.03588 30.86786  1.000 55.62240  ? 155 ASP A H    1 
ATOM   2372 H HA   . ASP A 1 155 ? -14.32386 -41.73388 29.21765  1.000 62.17533  ? 155 ASP A HA   1 
ATOM   2373 H HB2  . ASP A 1 155 ? -15.13079 -43.96847 29.35713  1.000 70.80267  ? 155 ASP A HB2  1 
ATOM   2374 H HB3  . ASP A 1 155 ? -14.68984 -43.42012 30.78201  1.000 70.80267  ? 155 ASP A HB3  1 
ATOM   2375 N N    . CYS A 1 156 ? -17.06021 -40.90279 28.14860  1.000 36.20151  ? 156 CYS A N    1 
ATOM   2376 C CA   . CYS A 1 156 ? -17.99930 -40.84964 27.04123  1.000 41.31612  ? 156 CYS A CA   1 
ATOM   2377 C C    . CYS A 1 156 ? -17.60117 -39.71064 26.10965  1.000 39.67906  ? 156 CYS A C    1 
ATOM   2378 O O    . CYS A 1 156 ? -17.45502 -38.56372 26.55893  1.000 36.98699  ? 156 CYS A O    1 
ATOM   2379 C CB   . CYS A 1 156 ? -19.43985 -40.64866 27.50859  1.000 43.61726  ? 156 CYS A CB   1 
ATOM   2380 S SG   . CYS A 1 156 ? -20.62413 -40.97544 26.15883  1.000 52.10026  ? 156 CYS A SG   1 
ATOM   2381 H H    . CYS A 1 156 ? -17.19357 -40.29767 28.74496  1.000 43.49591  ? 156 CYS A H    1 
ATOM   2382 H HA   . CYS A 1 156 ? -17.95394 -41.69414 26.56619  1.000 49.63345  ? 156 CYS A HA   1 
ATOM   2383 H HB2  . CYS A 1 156 ? -19.62941 -41.25954 28.23783  1.000 52.39481  ? 156 CYS A HB2  1 
ATOM   2384 H HB3  . CYS A 1 156 ? -19.55692 -39.73233 27.80448  1.000 52.39481  ? 156 CYS A HB3  1 
ATOM   2385 H HG   . CYS A 1 156 ? -21.64612 -41.39370 26.62851  1.000 62.57441  ? 156 CYS A HG   1 
ATOM   2386 N N    . VAL A 1 157 ? -17.41114 -40.02261 24.83323  1.000 32.99073  ? 157 VAL A N    1 
ATOM   2387 C CA   . VAL A 1 157 ? -17.12228 -39.01020 23.81924  1.000 35.33358  ? 157 VAL A CA   1 
ATOM   2388 C C    . VAL A 1 157 ? -18.44946 -38.56758 23.22704  1.000 31.45432  ? 157 VAL A C    1 
ATOM   2389 O O    . VAL A 1 157 ? -19.21656 -39.39783 22.72924  1.000 33.49600  ? 157 VAL A O    1 
ATOM   2390 C CB   . VAL A 1 157 ? -16.19566 -39.53316 22.71491  1.000 29.16662  ? 157 VAL A CB   1 
ATOM   2391 C CG1  . VAL A 1 157 ? -15.94275 -38.43139 21.65470  1.000 31.02218  ? 157 VAL A CG1  1 
ATOM   2392 C CG2  . VAL A 1 157 ? -14.90110 -39.99101 23.30568  1.000 32.59072  ? 157 VAL A CG2  1 
ATOM   2393 H H    . VAL A 1 157 ? -17.44444 -40.82417 24.52341  1.000 39.64298  ? 157 VAL A H    1 
ATOM   2394 H HA   . VAL A 1 157 ? -16.68006 -38.25902 24.24475  1.000 42.45439  ? 157 VAL A HA   1 
ATOM   2395 H HB   . VAL A 1 157 ? -16.61969 -40.28679 22.27543  1.000 35.05404  ? 157 VAL A HB   1 
ATOM   2396 H HG11 . VAL A 1 157 ? -16.78620 -38.00652 21.43338  1.000 37.28071  ? 157 VAL A HG11 1 
ATOM   2397 H HG12 . VAL A 1 157 ? -15.32827 -37.77609 22.02062  1.000 37.28071  ? 157 VAL A HG12 1 
ATOM   2398 H HG13 . VAL A 1 157 ? -15.55918 -38.83803 20.86197  1.000 37.28071  ? 157 VAL A HG13 1 
ATOM   2399 H HG21 . VAL A 1 157 ? -14.30983 -40.27324 22.59039  1.000 39.16296  ? 157 VAL A HG21 1 
ATOM   2400 H HG22 . VAL A 1 157 ? -14.50017 -39.25616 23.79572  1.000 39.16296  ? 157 VAL A HG22 1 
ATOM   2401 H HG23 . VAL A 1 157 ? -15.07284 -40.73384 23.90537  1.000 39.16296  ? 157 VAL A HG23 1 
ATOM   2402 N N    . SER A 1 158 ? -18.70614 -37.26770 23.26257  1.000 30.49728  ? 158 SER A N    1 
ATOM   2403 C CA   . SER A 1 158 ? -19.87955 -36.66036 22.65817  1.000 30.59022  ? 158 SER A CA   1 
ATOM   2404 C C    . SER A 1 158 ? -19.38229 -35.94200 21.41777  1.000 30.26023  ? 158 SER A C    1 
ATOM   2405 O O    . SER A 1 158 ? -18.75106 -34.89138 21.54665  1.000 28.36028  ? 158 SER A O    1 
ATOM   2406 C CB   . SER A 1 158 ? -20.56970 -35.66196 23.57737  1.000 34.15205  ? 158 SER A CB   1 
ATOM   2407 O OG   . SER A 1 158 ? -21.29135 -36.30995 24.59201  1.000 37.47315  ? 158 SER A OG   1 
ATOM   2408 H H    . SER A 1 158 ? -18.19305 -36.69476 23.64737  1.000 36.65083  ? 158 SER A H    1 
ATOM   2409 H HA   . SER A 1 158 ? -20.52304 -37.35406 22.44464  1.000 36.76236  ? 158 SER A HA   1 
ATOM   2410 H HB2  . SER A 1 158 ? -19.89672 -35.09478 23.98516  1.000 41.03656  ? 158 SER A HB2  1 
ATOM   2411 H HB3  . SER A 1 158 ? -21.18255 -35.12429 23.05179  1.000 41.03656  ? 158 SER A HB3  1 
ATOM   2412 H HG   . SER A 1 158 ? -20.76462 -36.71826 25.10332  1.000 45.02189  ? 158 SER A HG   1 
ATOM   2413 N N    . PHE A 1 159 ? -19.65356 -36.51020 20.25115  1.000 32.34252  ? 159 PHE A N    1 
ATOM   2414 C CA   . PHE A 1 159 ? -19.33798 -35.87636 18.98708  1.000 28.82500  ? 159 PHE A CA   1 
ATOM   2415 C C    . PHE A 1 159 ? -20.38668 -34.85788 18.59801  1.000 27.83467  ? 159 PHE A C    1 
ATOM   2416 O O    . PHE A 1 159 ? -21.58467 -35.15611 18.55227  1.000 34.24717  ? 159 PHE A O    1 
ATOM   2417 C CB   . PHE A 1 159 ? -19.23058 -36.94395 17.87664  1.000 26.03054  ? 159 PHE A CB   1 
ATOM   2418 C CG   . PHE A 1 159 ? -18.11382 -37.92795 18.09088  1.000 24.43113  ? 159 PHE A CG   1 
ATOM   2419 C CD1  . PHE A 1 159 ? -16.78160 -37.59516 17.77032  1.000 27.16281  ? 159 PHE A CD1  1 
ATOM   2420 C CD2  . PHE A 1 159 ? -18.38250 -39.18664 18.56191  1.000 30.73112  ? 159 PHE A CD2  1 
ATOM   2421 C CE1  . PHE A 1 159 ? -15.75841 -38.53686 17.93286  1.000 26.69354  ? 159 PHE A CE1  1 
ATOM   2422 C CE2  . PHE A 1 159 ? -17.35088 -40.11710 18.73258  1.000 26.04160  ? 159 PHE A CE2  1 
ATOM   2423 C CZ   . PHE A 1 159 ? -16.06508 -39.80945 18.42818  1.000 28.64004  ? 159 PHE A CZ   1 
ATOM   2424 H H    . PHE A 1 159 ? -20.02839 -37.27950 20.16582  1.000 38.86512  ? 159 PHE A H    1 
ATOM   2425 H HA   . PHE A 1 159 ? -18.49153 -35.41208 19.08126  1.000 34.64410  ? 159 PHE A HA   1 
ATOM   2426 H HB2  . PHE A 1 159 ? -20.06201 -37.44232 17.84125  1.000 31.29075  ? 159 PHE A HB2  1 
ATOM   2427 H HB3  . PHE A 1 159 ? -19.07453 -36.49841 17.02927  1.000 31.29075  ? 159 PHE A HB3  1 
ATOM   2428 H HD1  . PHE A 1 159 ? -16.58155 -36.74560 17.44920  1.000 32.64948  ? 159 PHE A HD1  1 
ATOM   2429 H HD2  . PHE A 1 159 ? -19.25723 -39.42442 18.76979  1.000 36.93144  ? 159 PHE A HD2  1 
ATOM   2430 H HE1  . PHE A 1 159 ? -14.88149 -38.31842 17.71334  1.000 32.08635  ? 159 PHE A HE1  1 
ATOM   2431 H HE2  . PHE A 1 159 ? -17.55098 -40.96369 19.06143  1.000 31.30402  ? 159 PHE A HE2  1 
ATOM   2432 H HZ   . PHE A 1 159 ? -15.39197 -40.43993 18.54784  1.000 34.42215  ? 159 PHE A HZ   1 
ATOM   2433 N N    . CYS A 1 160 ? -19.93266 -33.66783 18.23744  1.000 27.24644  ? 160 CYS A N    1 
ATOM   2434 C CA   . CYS A 1 160 ? -20.87997 -32.62337 17.95820  1.000 25.53017  ? 160 CYS A CA   1 
ATOM   2435 C C    . CYS A 1 160 ? -20.68218 -31.90958 16.63844  1.000 29.66415  ? 160 CYS A C    1 
ATOM   2436 O O    . CYS A 1 160 ? -21.58666 -31.17544 16.22903  1.000 30.79059  ? 160 CYS A O    1 
ATOM   2437 C CB   . CYS A 1 160 ? -20.85502 -31.57769 19.09199  1.000 28.11740  ? 160 CYS A CB   1 
ATOM   2438 S SG   . CYS A 1 160 ? -19.25606 -30.75384 19.37503  1.000 29.91998  ? 160 CYS A SG   1 
ATOM   2439 H H    . CYS A 1 160 ? -19.10386 -33.45468 18.15219  1.000 32.74982  ? 160 CYS A H    1 
ATOM   2440 H HA   . CYS A 1 160 ? -21.76283 -33.02376 17.92443  1.000 30.69030  ? 160 CYS A HA   1 
ATOM   2441 H HB2  . CYS A 1 160 ? -21.50158 -30.88592 18.88149  1.000 33.79498  ? 160 CYS A HB2  1 
ATOM   2442 H HB3  . CYS A 1 160 ? -21.10060 -32.02068 19.91924  1.000 33.79498  ? 160 CYS A HB3  1 
ATOM   2443 H HG   . CYS A 1 160 ? -19.01394 -30.03959 18.44163  1.000 35.95808  ? 160 CYS A HG   1 
ATOM   2444 N N    . TYR A 1 161 ? -19.57576 -32.13329 15.93212  1.000 26.20378  ? 161 TYR A N    1 
ATOM   2445 C CA   . TYR A 1 161 ? -19.23312 -31.33664 14.76681  1.000 23.08753  ? 161 TYR A CA   1 
ATOM   2446 C C    . TYR A 1 161 ? -18.46978 -32.21536 13.78689  1.000 25.44796  ? 161 TYR A C    1 
ATOM   2447 O O    . TYR A 1 161 ? -17.57882 -32.96023 14.20047  1.000 24.07788  ? 161 TYR A O    1 
ATOM   2448 C CB   . TYR A 1 161 ? -18.32849 -30.13367 15.09999  1.000 24.45561  ? 161 TYR A CB   1 
ATOM   2449 C CG   . TYR A 1 161 ? -17.92093 -29.25602 13.93260  1.000 25.39290  ? 161 TYR A CG   1 
ATOM   2450 C CD1  . TYR A 1 161 ? -18.76442 -28.27190 13.50758  1.000 24.95658  ? 161 TYR A CD1  1 
ATOM   2451 C CD2  . TYR A 1 161 ? -16.65701 -29.35533 13.31344  1.000 24.47750  ? 161 TYR A CD2  1 
ATOM   2452 C CE1  . TYR A 1 161 ? -18.42990 -27.45897 12.45205  1.000 26.71237  ? 161 TYR A CE1  1 
ATOM   2453 C CE2  . TYR A 1 161 ? -16.29286 -28.51412 12.28457  1.000 26.50899  ? 161 TYR A CE2  1 
ATOM   2454 C CZ   . TYR A 1 161 ? -17.18805 -27.58889 11.84583  1.000 27.98854  ? 161 TYR A CZ   1 
ATOM   2455 O OH   . TYR A 1 161 ? -16.87172 -26.74255 10.82225  1.000 26.29845  ? 161 TYR A OH   1 
ATOM   2456 H H    . TYR A 1 161 ? -19.00332 -32.74901 16.11324  1.000 31.49864  ? 161 TYR A H    1 
ATOM   2457 H HA   . TYR A 1 161 ? -20.06031 -31.01172 14.37810  1.000 27.75913  ? 161 TYR A HA   1 
ATOM   2458 H HB2  . TYR A 1 161 ? -18.79923 -29.56764 15.73159  1.000 29.40083  ? 161 TYR A HB2  1 
ATOM   2459 H HB3  . TYR A 1 161 ? -17.51255 -30.47144 15.50132  1.000 29.40083  ? 161 TYR A HB3  1 
ATOM   2460 H HD1  . TYR A 1 161 ? -19.57897 -28.14935 13.93931  1.000 30.00200  ? 161 TYR A HD1  1 
ATOM   2461 H HD2  . TYR A 1 161 ? -16.05667 -30.00254 13.60606  1.000 29.42710  ? 161 TYR A HD2  1 
ATOM   2462 H HE1  . TYR A 1 161 ? -19.03434 -26.82275 12.14418  1.000 32.10895  ? 161 TYR A HE1  1 
ATOM   2463 H HE2  . TYR A 1 161 ? -15.44987 -28.57790 11.89701  1.000 31.86488  ? 161 TYR A HE2  1 
ATOM   2464 H HH   . TYR A 1 161 ? -16.04150 -26.74401 10.69440  1.000 31.61224  ? 161 TYR A HH   1 
ATOM   2465 N N    . MET A 1 162 ? -18.71878 -32.00387 12.49804  1.000 21.96434  ? 162 MET A N    1 
ATOM   2466 C CA   . MET A 1 162 ? -17.93060 -32.55867 11.40108  1.000 24.89905  ? 162 MET A CA   1 
ATOM   2467 C C    . MET A 1 162 ? -17.66671 -31.43467 10.41713  1.000 26.50619  ? 162 MET A C    1 
ATOM   2468 O O    . MET A 1 162 ? -18.58696 -30.69343 10.08059  1.000 23.10268  ? 162 MET A O    1 
ATOM   2469 C CB   . MET A 1 162 ? -18.64426 -33.72747 10.68382  1.000 26.86420  ? 162 MET A CB   1 
ATOM   2470 C CG   . MET A 1 162 ? -17.79163 -34.29683 9.60904   1.000 31.56492  ? 162 MET A CG   1 
ATOM   2471 S SD   . MET A 1 162 ? -18.34103 -35.89190 8.93450   1.000 28.21463  ? 162 MET A SD   1 
ATOM   2472 C CE   . MET A 1 162 ? -17.42971 -37.02287 9.96887   1.000 29.74934  ? 162 MET A CE   1 
ATOM   2473 H H    . MET A 1 162 ? -19.37153 -31.51812 12.21954  1.000 26.41131  ? 162 MET A H    1 
ATOM   2474 H HA   . MET A 1 162 ? -17.09990 -32.91413 11.75391  1.000 29.93297  ? 162 MET A HA   1 
ATOM   2475 H HB2  . MET A 1 162 ? -18.83858 -34.42840 11.32557  1.000 32.29114  ? 162 MET A HB2  1 
ATOM   2476 H HB3  . MET A 1 162 ? -19.46764 -33.40553 10.28468  1.000 32.29114  ? 162 MET A HB3  1 
ATOM   2477 H HG2  . MET A 1 162 ? -17.76695 -33.66594 8.87264   1.000 37.93200  ? 162 MET A HG2  1 
ATOM   2478 H HG3  . MET A 1 162 ? -16.89856 -34.42683 9.96460   1.000 37.93200  ? 162 MET A HG3  1 
ATOM   2479 H HE1  . MET A 1 162 ? -17.38858 -36.66421 10.86919  1.000 35.75332  ? 162 MET A HE1  1 
ATOM   2480 H HE2  . MET A 1 162 ? -17.88289 -37.88048 9.97483   1.000 35.75332  ? 162 MET A HE2  1 
ATOM   2481 H HE3  . MET A 1 162 ? -16.53346 -37.12482 9.61216   1.000 35.75332  ? 162 MET A HE3  1 
ATOM   2482 N N    . HIS A 1 163 ? -16.41800 -31.29187 9.98175   1.000 26.18476  ? 163 HIS A N    1 
ATOM   2483 C CA   . HIS A 1 163 ? -16.01209 -30.14638 9.17679   1.000 26.88123  ? 163 HIS A CA   1 
ATOM   2484 C C    . HIS A 1 163 ? -16.33872 -30.32642 7.69456   1.000 25.36949  ? 163 HIS A C    1 
ATOM   2485 O O    . HIS A 1 163 ? -16.01875 -31.38764 7.11569   1.000 29.49505  ? 163 HIS A O    1 
ATOM   2486 C CB   . HIS A 1 163 ? -14.50614 -29.85796 9.27265   1.000 25.58261  ? 163 HIS A CB   1 
ATOM   2487 C CG   . HIS A 1 163 ? -14.15701 -28.58299 8.58802   1.000 24.94838  ? 163 HIS A CG   1 
ATOM   2488 N ND1  . HIS A 1 163 ? -14.79188 -27.39590 8.90145   1.000 26.71647  ? 163 HIS A ND1  1 
ATOM   2489 C CD2  . HIS A 1 163 ? -13.37077 -28.31269 7.51688   1.000 28.44695  ? 163 HIS A CD2  1 
ATOM   2490 C CE1  . HIS A 1 163 ? -14.35896 -26.43791 8.10216   1.000 30.63871  ? 163 HIS A CE1  1 
ATOM   2491 N NE2  . HIS A 1 163 ? -13.46815 -26.96417 7.27244   1.000 29.41581  ? 163 HIS A NE2  1 
ATOM   2492 H H    . HIS A 1 163 ? -15.78273 -31.84935 10.14061  1.000 31.47581  ? 163 HIS A H    1 
ATOM   2493 H HA   . HIS A 1 163 ? -16.51399 -29.39774 9.53533   1.000 32.31158  ? 163 HIS A HA   1 
ATOM   2494 H HB2  . HIS A 1 163 ? -14.25142 -29.78484 10.20575  1.000 30.75323  ? 163 HIS A HB2  1 
ATOM   2495 H HB3  . HIS A 1 163 ? -14.01313 -30.57830 8.84963   1.000 30.75323  ? 163 HIS A HB3  1 
ATOM   2496 H HD2  . HIS A 1 163 ? -12.86108 -28.92531 7.03748   1.000 34.19044  ? 163 HIS A HD2  1 
ATOM   2497 H HE1  . HIS A 1 163 ? -14.63138 -25.54885 8.11830   1.000 36.82055  ? 163 HIS A HE1  1 
ATOM   2498 H HE2  . HIS A 1 163 ? -13.02321 -26.53116 6.67736   1.000 35.35307  ? 163 HIS A HE2  1 
ATOM   2499 N N    . HIS A 1 164 ? -16.91580 -29.27490 7.07346   1.000 26.52957  ? 164 HIS A N    1 
ATOM   2500 C CA   . HIS A 1 164 ? -17.23476 -29.31982 5.64610   1.000 25.71803  ? 164 HIS A CA   1 
ATOM   2501 C C    . HIS A 1 164 ? -16.73754 -28.17863 4.75336   1.000 30.96279  ? 164 HIS A C    1 
ATOM   2502 O O    . HIS A 1 164 ? -16.51921 -28.40243 3.57180   1.000 27.89253  ? 164 HIS A O    1 
ATOM   2503 C CB   . HIS A 1 164 ? -18.74448 -29.34485 5.37459   1.000 27.34673  ? 164 HIS A CB   1 
ATOM   2504 C CG   . HIS A 1 164 ? -19.44351 -30.56093 5.85477   1.000 29.31988  ? 164 HIS A CG   1 
ATOM   2505 N ND1  . HIS A 1 164 ? -20.08096 -31.42971 5.00289   1.000 24.92488  ? 164 HIS A ND1  1 
ATOM   2506 C CD2  . HIS A 1 164 ? -19.63161 -31.04863 7.10154   1.000 25.79311  ? 164 HIS A CD2  1 
ATOM   2507 C CE1  . HIS A 1 164 ? -20.64572 -32.39337 5.69250   1.000 24.38654  ? 164 HIS A CE1  1 
ATOM   2508 N NE2  . HIS A 1 164 ? -20.36318 -32.20469 6.97459   1.000 25.91132  ? 164 HIS A NE2  1 
ATOM   2509 H H    . HIS A 1 164 ? -17.12670 -28.53622 7.46008   1.000 31.88958  ? 164 HIS A H    1 
ATOM   2510 H HA   . HIS A 1 164 ? -16.76817 -30.13439 5.40182   1.000 30.91574  ? 164 HIS A HA   1 
ATOM   2511 H HB2  . HIS A 1 164 ? -19.14931 -28.58227 5.81674   1.000 32.87018  ? 164 HIS A HB2  1 
ATOM   2512 H HB3  . HIS A 1 164 ? -18.88585 -29.28652 4.41672   1.000 32.87018  ? 164 HIS A HB3  1 
ATOM   2513 H HD1  . HIS A 1 164 ? -20.10625 -31.35374 4.14663   1.000 29.96395  ? 164 HIS A HD1  1 
ATOM   2514 H HD2  . HIS A 1 164 ? -19.32412 -30.67288 7.89474   1.000 31.00584  ? 164 HIS A HD2  1 
ATOM   2515 H HE1  . HIS A 1 164 ? -21.15561 -33.08804 5.34271   1.000 29.31795  ? 164 HIS A HE1  1 
ATOM   2516 N N    . MET A 1 165 ? -16.62775 -26.95555 5.26016   1.000 27.74890  ? 165 MET A N    1 
ATOM   2517 C CA   . MET A 1 165 ? -16.49082 -25.81932 4.35622   1.000 30.41160  ? 165 MET A CA   1 
ATOM   2518 C C    . MET A 1 165 ? -15.90927 -24.59840 5.04545   1.000 31.72227  ? 165 MET A C    1 
ATOM   2519 O O    . MET A 1 165 ? -16.00974 -24.43660 6.25803   1.000 28.02256  ? 165 MET A O    1 
ATOM   2520 C CB   . MET A 1 165 ? -17.87118 -25.53504 3.73746   1.000 32.85152  ? 165 MET A CB   1 
ATOM   2521 C CG   . MET A 1 165 ? -18.03471 -24.20380 3.05664   1.000 45.56765  ? 165 MET A CG   1 
ATOM   2522 S SD   . MET A 1 165 ? -19.51692 -24.06260 1.96535   1.000 45.09147  ? 165 MET A SD   1 
ATOM   2523 C CE   . MET A 1 165 ? -20.43130 -25.47758 2.19393   1.000 44.30002  ? 165 MET A CE   1 
ATOM   2524 H H    . MET A 1 165 ? -16.62975 -26.76312 6.09835   1.000 33.35278  ? 165 MET A H    1 
ATOM   2525 H HA   . MET A 1 165 ? -15.84447 -26.02701 3.66341   1.000 36.54802  ? 165 MET A HA   1 
ATOM   2526 H HB2  . MET A 1 165 ? -18.05110 -26.21897 3.07356   1.000 39.47593  ? 165 MET A HB2  1 
ATOM   2527 H HB3  . MET A 1 165 ? -18.53357 -25.57694 4.44485   1.000 39.47593  ? 165 MET A HB3  1 
ATOM   2528 H HG2  . MET A 1 165 ? -18.10916 -23.51724 3.73782   1.000 54.73528  ? 165 MET A HG2  1 
ATOM   2529 H HG3  . MET A 1 165 ? -17.25248 -24.04178 2.50640   1.000 54.73528  ? 165 MET A HG3  1 
ATOM   2530 H HE1  . MET A 1 165 ? -20.86243 -25.71352 1.35765   1.000 53.21412  ? 165 MET A HE1  1 
ATOM   2531 H HE2  . MET A 1 165 ? -19.84027 -26.19357 2.47490   1.000 53.21412  ? 165 MET A HE2  1 
ATOM   2532 H HE3  . MET A 1 165 ? -21.10073 -25.31415 2.87661   1.000 53.21412  ? 165 MET A HE3  1 
ATOM   2533 N N    . GLU A 1 166 ? -15.22823 -23.77394 4.25181   1.000 31.01607  ? 166 GLU A N    1 
ATOM   2534 C CA   . GLU A 1 166 ? -14.71853 -22.48977 4.70078   1.000 30.78459  ? 166 GLU A CA   1 
ATOM   2535 C C    . GLU A 1 166 ? -15.41953 -21.36325 3.95401   1.000 41.07762  ? 166 GLU A C    1 
ATOM   2536 O O    . GLU A 1 166 ? -15.46633 -21.37168 2.71882   1.000 36.86631  ? 166 GLU A O    1 
ATOM   2537 C CB   . GLU A 1 166 ? -13.21505 -22.37255 4.48755   1.000 34.18082  ? 166 GLU A CB   1 
ATOM   2538 C CG   . GLU A 1 166 ? -12.68054 -20.99364 4.85735   1.000 33.23210  ? 166 GLU A CG   1 
ATOM   2539 C CD   . GLU A 1 166 ? -11.18332 -20.95777 4.77277   1.000 40.24689  ? 166 GLU A CD   1 
ATOM   2540 O OE1  . GLU A 1 166 ? -10.54452 -21.94333 5.24068   1.000 31.90976  ? 166 GLU A OE1  1 
ATOM   2541 O OE2  . GLU A 1 166 ? -10.64945 -19.95718 4.21367   1.000 40.05474  ? 166 GLU A OE2  1 
ATOM   2542 H H    . GLU A 1 166 ? -15.04668 -23.94525 3.42883   1.000 37.27339  ? 166 GLU A H    1 
ATOM   2543 H HA   . GLU A 1 166 ? -14.90472 -22.40393 5.64887   1.000 36.99561  ? 166 GLU A HA   1 
ATOM   2544 H HB2  . GLU A 1 166 ? -12.76435 -23.02928 5.04117   1.000 41.07109  ? 166 GLU A HB2  1 
ATOM   2545 H HB3  . GLU A 1 166 ? -13.01419 -22.53314 3.55226   1.000 41.07109  ? 166 GLU A HB3  1 
ATOM   2546 H HG2  . GLU A 1 166 ? -13.03905 -20.33318 4.24402   1.000 39.93262  ? 166 GLU A HG2  1 
ATOM   2547 H HG3  . GLU A 1 166 ? -12.94238 -20.77891 5.76632   1.000 39.93262  ? 166 GLU A HG3  1 
ATOM   2548 N N    . LEU A 1 167 ? -15.93666 -20.39649 4.70699   1.000 41.33640  ? 167 LEU A N    1 
ATOM   2549 C CA   . LEU A 1 167 ? -16.64981 -19.26280 4.13897   1.000 43.57118  ? 167 LEU A CA   1 
ATOM   2550 C C    . LEU A 1 167 ? -15.68077 -18.21675 3.59973   1.000 47.64165  ? 167 LEU A C    1 
ATOM   2551 O O    . LEU A 1 167 ? -14.51415 -18.15659 4.01179   1.000 34.86463  ? 167 LEU A O    1 
ATOM   2552 C CB   . LEU A 1 167 ? -17.54005 -18.62449 5.19439   1.000 44.05520  ? 167 LEU A CB   1 
ATOM   2553 C CG   . LEU A 1 167 ? -18.67018 -19.48396 5.78123   1.000 36.54235  ? 167 LEU A CG   1 
ATOM   2554 C CD1  . LEU A 1 167 ? -19.61369 -18.63941 6.66199   1.000 36.40428  ? 167 LEU A CD1  1 
ATOM   2555 C CD2  . LEU A 1 167 ? -19.39977 -20.15295 4.65110   1.000 40.71854  ? 167 LEU A CD2  1 
ATOM   2556 H H    . LEU A 1 167 ? -15.88597 -20.37547 5.56524   1.000 49.65778  ? 167 LEU A H    1 
ATOM   2557 H HA   . LEU A 1 167 ? -17.20368 -19.57439 3.40615   1.000 52.33952  ? 167 LEU A HA   1 
ATOM   2558 H HB2  . LEU A 1 167 ? -16.97561 -18.35757 5.93672   1.000 52.92034  ? 167 LEU A HB2  1 
ATOM   2559 H HB3  . LEU A 1 167 ? -17.95764 -17.84397 4.79776   1.000 52.92034  ? 167 LEU A HB3  1 
ATOM   2560 H HG   . LEU A 1 167 ? -18.30648 -20.16920 6.36353   1.000 43.90493  ? 167 LEU A HG   1 
ATOM   2561 H HD11 . LEU A 1 167 ? -20.23917 -19.22951 7.11083   1.000 43.73924  ? 167 LEU A HD11 1 
ATOM   2562 H HD12 . LEU A 1 167 ? -19.08607 -18.15654 7.31724   1.000 43.73924  ? 167 LEU A HD12 1 
ATOM   2563 H HD13 . LEU A 1 167 ? -20.09534 -18.01347 6.09887   1.000 43.73924  ? 167 LEU A HD13 1 
ATOM   2564 H HD21 . LEU A 1 167 ? -19.58218 -19.49663 3.96054   1.000 48.91635  ? 167 LEU A HD21 1 
ATOM   2565 H HD22 . LEU A 1 167 ? -18.84473 -20.86364 4.29367   1.000 48.91635  ? 167 LEU A HD22 1 
ATOM   2566 H HD23 . LEU A 1 167 ? -20.23248 -20.52045 4.98641   1.000 48.91635  ? 167 LEU A HD23 1 
ATOM   2567 N N    . PRO A 1 168 ? -16.15486 -17.34953 2.69764   1.000 45.68126  ? 168 PRO A N    1 
ATOM   2568 C CA   . PRO A 1 168 ? -15.28619 -16.27920 2.18739   1.000 45.90414  ? 168 PRO A CA   1 
ATOM   2569 C C    . PRO A 1 168 ? -14.62934 -15.48615 3.27904   1.000 40.61658  ? 168 PRO A C    1 
ATOM   2570 O O    . PRO A 1 168 ? -13.52839 -14.96473 3.07465   1.000 48.46247  ? 168 PRO A O    1 
ATOM   2571 C CB   . PRO A 1 168 ? -16.24586 -15.40051 1.36944   1.000 48.65345  ? 168 PRO A CB   1 
ATOM   2572 C CG   . PRO A 1 168 ? -17.37369 -16.29101 1.00172   1.000 51.77599  ? 168 PRO A CG   1 
ATOM   2573 C CD   . PRO A 1 168 ? -17.51863 -17.27939 2.14452   1.000 45.16700  ? 168 PRO A CD   1 
ATOM   2574 H HA   . PRO A 1 168 ? -14.61342 -16.65481 1.59815   1.000 55.13907  ? 168 PRO A HA   1 
ATOM   2575 H HB2  . PRO A 1 168 ? -16.55410 -14.65732 1.91125   1.000 58.43824  ? 168 PRO A HB2  1 
ATOM   2576 H HB3  . PRO A 1 168 ? -15.79427 -15.06893 0.57759   1.000 58.43824  ? 168 PRO A HB3  1 
ATOM   2577 H HG2  . PRO A 1 168 ? -18.18296 -15.76648 0.89753   1.000 62.18529  ? 168 PRO A HG2  1 
ATOM   2578 H HG3  . PRO A 1 168 ? -17.16846 -16.75239 0.17352   1.000 62.18529  ? 168 PRO A HG3  1 
ATOM   2579 H HD2  . PRO A 1 168 ? -18.14517 -16.95156 2.80851   1.000 54.25451  ? 168 PRO A HD2  1 
ATOM   2580 H HD3  . PRO A 1 168 ? -17.80490 -18.14675 1.81798   1.000 54.25451  ? 168 PRO A HD3  1 
ATOM   2581 N N    . THR A 1 169 ? -15.28355 -15.34276 4.44308   1.000 39.91702  ? 169 THR A N    1 
ATOM   2582 C CA   . THR A 1 169 ? -14.67014 -14.57784 5.51570   1.000 41.44515  ? 169 THR A CA   1 
ATOM   2583 C C    . THR A 1 169 ? -13.52503 -15.32244 6.19438   1.000 42.98452  ? 169 THR A C    1 
ATOM   2584 O O    . THR A 1 169 ? -12.90924 -14.75295 7.10301   1.000 45.46531  ? 169 THR A O    1 
ATOM   2585 C CB   . THR A 1 169 ? -15.70242 -14.19704 6.58578   1.000 46.96658  ? 169 THR A CB   1 
ATOM   2586 O OG1  . THR A 1 169 ? -16.45305 -15.36523 6.95157   1.000 47.72649  ? 169 THR A OG1  1 
ATOM   2587 C CG2  . THR A 1 169 ? -16.65405 -13.10128 6.10333   1.000 40.69938  ? 169 THR A CG2  1 
ATOM   2588 H H    . THR A 1 169 ? -16.05796 -15.67174 4.62100   1.000 47.95453  ? 169 THR A H    1 
ATOM   2589 H HA   . THR A 1 169 ? -14.32802 -13.75850 5.12515   1.000 49.78828  ? 169 THR A HA   1 
ATOM   2590 H HB   . THR A 1 169 ? -15.23679 -13.84424 7.36013   1.000 56.41400  ? 169 THR A HB   1 
ATOM   2591 H HG1  . THR A 1 169 ? -16.00545 -16.05706 6.78842   1.000 57.32588  ? 169 THR A HG1  1 
ATOM   2592 H HG21 . THR A 1 169 ? -17.20607 -13.43633 5.37951   1.000 48.89336  ? 169 THR A HG21 1 
ATOM   2593 H HG22 . THR A 1 169 ? -17.22833 -12.81645 6.83133   1.000 48.89336  ? 169 THR A HG22 1 
ATOM   2594 H HG23 . THR A 1 169 ? -16.14704 -12.33798 5.78520   1.000 48.89336  ? 169 THR A HG23 1 
ATOM   2595 N N    . GLY A 1 170 ? -13.25567 -16.56708 5.82421   1.000 42.74186  ? 170 GLY A N    1 
ATOM   2596 C CA   . GLY A 1 170 ? -12.22618 -17.36263 6.47221   1.000 40.38040  ? 170 GLY A CA   1 
ATOM   2597 C C    . GLY A 1 170 ? -12.65053 -18.12008 7.71210   1.000 45.21735  ? 170 GLY A C    1 
ATOM   2598 O O    . GLY A 1 170 ? -11.78986 -18.72775 8.36427   1.000 38.78546  ? 170 GLY A O    1 
ATOM   2599 H H    . GLY A 1 170 ? -13.66293 -16.97980 5.18908   1.000 51.34434  ? 170 GLY A H    1 
ATOM   2600 H HA2  . GLY A 1 170 ? -11.89570 -18.01339 5.83331   1.000 48.51058  ? 170 GLY A HA2  1 
ATOM   2601 H HA3  . GLY A 1 170 ? -11.49942 -16.77280 6.72681   1.000 48.51058  ? 170 GLY A HA3  1 
ATOM   2602 N N    . VAL A 1 171 ? -13.94456 -18.09751 8.06114   1.000 37.04365  ? 171 VAL A N    1 
ATOM   2603 C CA   . VAL A 1 171 ? -14.47025 -18.83671 9.20516   1.000 35.33325  ? 171 VAL A CA   1 
ATOM   2604 C C    . VAL A 1 171 ? -14.95097 -20.17100 8.64549   1.000 31.19817  ? 171 VAL A C    1 
ATOM   2605 O O    . VAL A 1 171 ? -15.00601 -20.37384 7.41939   1.000 30.81298  ? 171 VAL A O    1 
ATOM   2606 C CB   . VAL A 1 171 ? -15.60051 -18.11031 9.96055   1.000 33.33198  ? 171 VAL A CB   1 
ATOM   2607 C CG1  . VAL A 1 171 ? -15.07071 -16.83013 10.64591  1.000 38.21752  ? 171 VAL A CG1  1 
ATOM   2608 C CG2  . VAL A 1 171 ? -16.76405 -17.80532 9.03205   1.000 38.81026  ? 171 VAL A CG2  1 
ATOM   2609 H H    . VAL A 1 171 ? -14.54618 -17.65075 7.63918   1.000 44.50649  ? 171 VAL A H    1 
ATOM   2610 H HA   . VAL A 1 171 ? -13.76779 -18.95539 9.86346   1.000 42.45400  ? 171 VAL A HA   1 
ATOM   2611 H HB   . VAL A 1 171 ? -15.93346 -18.69576 10.65862  1.000 40.05248  ? 171 VAL A HB   1 
ATOM   2612 H HG11 . VAL A 1 171 ? -15.80974 -16.37467 11.07869  1.000 45.91513  ? 171 VAL A HG11 1 
ATOM   2613 H HG12 . VAL A 1 171 ? -14.40332 -17.07777 11.30481  1.000 45.91513  ? 171 VAL A HG12 1 
ATOM   2614 H HG13 . VAL A 1 171 ? -14.67436 -16.25330 9.97429   1.000 45.91513  ? 171 VAL A HG13 1 
ATOM   2615 H HG21 . VAL A 1 171 ? -17.36340 -17.18172 9.47114   1.000 46.62641  ? 171 VAL A HG21 1 
ATOM   2616 H HG22 . VAL A 1 171 ? -16.42078 -17.41370 8.21370   1.000 46.62641  ? 171 VAL A HG22 1 
ATOM   2617 H HG23 . VAL A 1 171 ? -17.23343 -18.63038 8.83240   1.000 46.62641  ? 171 VAL A HG23 1 
ATOM   2618 N N    . HIS A 1 172 ? -15.31015 -21.06906 9.53408   1.000 28.52074  ? 172 HIS A N    1 
ATOM   2619 C CA   . HIS A 1 172 ? -15.46775 -22.47722 9.17249   1.000 29.85767  ? 172 HIS A CA   1 
ATOM   2620 C C    . HIS A 1 172 ? -16.83103 -22.95934 9.59144   1.000 27.26691  ? 172 HIS A C    1 
ATOM   2621 O O    . HIS A 1 172 ? -17.31942 -22.56661 10.64957  1.000 24.87845  ? 172 HIS A O    1 
ATOM   2622 C CB   . HIS A 1 172 ? -14.36940 -23.30318 9.82787   1.000 27.93283  ? 172 HIS A CB   1 
ATOM   2623 C CG   . HIS A 1 172 ? -13.01009 -22.93421 9.33456   1.000 30.93390  ? 172 HIS A CG   1 
ATOM   2624 N ND1  . HIS A 1 172 ? -12.07913 -22.29737 10.12301  1.000 29.31649  ? 172 HIS A ND1  1 
ATOM   2625 C CD2  . HIS A 1 172 ? -12.45998 -23.04631 8.09756   1.000 30.40844  ? 172 HIS A CD2  1 
ATOM   2626 C CE1  . HIS A 1 172 ? -10.98778 -22.06100 9.40290   1.000 30.45987  ? 172 HIS A CE1  1 
ATOM   2627 N NE2  . HIS A 1 172 ? -11.19285 -22.51536 8.17372   1.000 30.61977  ? 172 HIS A NE2  1 
ATOM   2628 H H    . HIS A 1 172 ? -15.47154 -20.89569 10.36082  1.000 34.27899  ? 172 HIS A H    1 
ATOM   2629 H HA   . HIS A 1 172 ? -15.41181 -22.59547 8.21135   1.000 35.88331  ? 172 HIS A HA   1 
ATOM   2630 H HB2  . HIS A 1 172 ? -14.39241 -23.15776 10.78663  1.000 33.57350  ? 172 HIS A HB2  1 
ATOM   2631 H HB3  . HIS A 1 172 ? -14.51769 -24.24134 9.63095   1.000 33.57350  ? 172 HIS A HB3  1 
ATOM   2632 H HD2  . HIS A 1 172 ? -12.86282 -23.41204 7.34333   1.000 36.54423  ? 172 HIS A HD2  1 
ATOM   2633 H HE1  . HIS A 1 172 ? -10.21272 -21.64768 9.70844   1.000 36.60594  ? 172 HIS A HE1  1 
ATOM   2634 H HE2  . HIS A 1 172 ? -10.62531 -22.48327 7.52838   1.000 36.79782  ? 172 HIS A HE2  1 
ATOM   2635 N N    . VAL A 1 173 ? -17.41679 -23.84005 8.77123   1.000 24.68957  ? 173 VAL A N    1 
ATOM   2636 C CA   . VAL A 1 173 ? -18.76378 -24.33752 8.95900   1.000 24.02000  ? 173 VAL A CA   1 
ATOM   2637 C C    . VAL A 1 173 ? -18.82475 -25.83288 8.66995   1.000 25.06830  ? 173 VAL A C    1 
ATOM   2638 O O    . VAL A 1 173 ? -18.00366 -26.39033 7.94154   1.000 26.85745  ? 173 VAL A O    1 
ATOM   2639 C CB   . VAL A 1 173 ? -19.80470 -23.60069 8.10096   1.000 25.10317  ? 173 VAL A CB   1 
ATOM   2640 C CG1  . VAL A 1 173 ? -19.77674 -22.07854 8.47488   1.000 26.94966  ? 173 VAL A CG1  1 
ATOM   2641 C CG2  . VAL A 1 173 ? -19.61405 -23.81401 6.58019   1.000 28.04211  ? 173 VAL A CG2  1 
ATOM   2642 H H    . VAL A 1 173 ? -17.03144 -24.16979 8.07670   1.000 29.68159  ? 173 VAL A H    1 
ATOM   2643 H HA   . VAL A 1 173 ? -18.98926 -24.20944 9.89370   1.000 28.87810  ? 173 VAL A HA   1 
ATOM   2644 N N    . GLY A 1 174 ? -19.87445 -26.43647 9.20787   1.000 26.45988  ? 174 GLY A N    1 
ATOM   2645 C CA   . GLY A 1 174 ? -19.98824 -27.88488 9.22325   1.000 27.72669  ? 174 GLY A CA   1 
ATOM   2646 C C    . GLY A 1 174 ? -21.27690 -28.32482 9.87249   1.000 25.72887  ? 174 GLY A C    1 
ATOM   2647 O O    . GLY A 1 174 ? -22.17252 -27.52527 10.12976  1.000 26.89987  ? 174 GLY A O    1 
ATOM   2648 H H    . GLY A 1 174 ? -20.53795 -26.02843 9.57240   1.000 31.80595  ? 174 GLY A H    1 
ATOM   2649 H HA2  . GLY A 1 174 ? -19.96765 -28.22318 8.31439   1.000 33.32613  ? 174 GLY A HA2  1 
ATOM   2650 H HA3  . GLY A 1 174 ? -19.24592 -28.26498 9.71861   1.000 33.32613  ? 174 GLY A HA3  1 
ATOM   2651 N N    . THR A 1 175 ? -21.36559 -29.62321 10.11249  1.000 27.09266  ? 175 THR A N    1 
ATOM   2652 C CA   . THR A 1 175 ? -22.60337 -30.29190 10.46809  1.000 24.35879  ? 175 THR A CA   1 
ATOM   2653 C C    . THR A 1 175 ? -22.43470 -30.95149 11.83528  1.000 27.50595  ? 175 THR A C    1 
ATOM   2654 O O    . THR A 1 175 ? -21.32162 -31.07930 12.35649  1.000 29.28349  ? 175 THR A O    1 
ATOM   2655 C CB   . THR A 1 175 ? -22.96853 -31.38715 9.43315   1.000 25.93135  ? 175 THR A CB   1 
ATOM   2656 O OG1  . THR A 1 175 ? -21.95882 -32.41010 9.43078   1.000 23.64437  ? 175 THR A OG1  1 
ATOM   2657 C CG2  . THR A 1 175 ? -23.13496 -30.81016 8.02356   1.000 26.77648  ? 175 THR A CG2  1 
ATOM   2658 H H    . THR A 1 175 ? -20.69387 -30.15882 10.07365  1.000 32.56530  ? 175 THR A H    1 
ATOM   2659 H HA   . THR A 1 175 ? -23.31911 -29.63799 10.49982  1.000 29.28464  ? 175 THR A HA   1 
ATOM   2660 H HB   . THR A 1 175 ? -23.82107 -31.77727 9.68195   1.000 31.17172  ? 175 THR A HB   1 
ATOM   2661 H HG1  . THR A 1 175 ? -22.13197 -32.98606 10.01721  1.000 28.42735  ? 175 THR A HG1  1 
ATOM   2662 H HG21 . THR A 1 175 ? -22.65557 -29.97010 7.95021   1.000 32.18587  ? 175 THR A HG21 1 
ATOM   2663 H HG22 . THR A 1 175 ? -22.78333 -31.43164 7.36704   1.000 32.18587  ? 175 THR A HG22 1 
ATOM   2664 H HG23 . THR A 1 175 ? -24.07410 -30.65394 7.83777   1.000 32.18587  ? 175 THR A HG23 1 
ATOM   2665 N N    . ASP A 1 176 ? -23.55956 -31.42521 12.38007  1.000 27.97395  ? 176 ASP A N    1 
ATOM   2666 C CA   . ASP A 1 176 ? -23.55720 -32.39976 13.46128  1.000 28.92217  ? 176 ASP A CA   1 
ATOM   2667 C C    . ASP A 1 176 ? -23.35729 -33.79405 12.84543  1.000 26.02180  ? 176 ASP A C    1 
ATOM   2668 O O    . ASP A 1 176 ? -23.18697 -33.93623 11.62880  1.000 27.58832  ? 176 ASP A O    1 
ATOM   2669 C CB   . ASP A 1 176 ? -24.84152 -32.29191 14.30171  1.000 30.81105  ? 176 ASP A CB   1 
ATOM   2670 C CG   . ASP A 1 176 ? -26.13274 -32.62064 13.54083  1.000 33.38822  ? 176 ASP A CG   1 
ATOM   2671 O OD1  . ASP A 1 176 ? -26.07046 -33.33788 12.50982  1.000 31.83961  ? 176 ASP A OD1  1 
ATOM   2672 O OD2  . ASP A 1 176 ? -27.23178 -32.17732 14.00015  1.000 32.95322  ? 176 ASP A OD2  1 
ATOM   2673 H H    . ASP A 1 176 ? -24.34901 -31.19020 12.13281  1.000 33.62285  ? 176 ASP A H    1 
ATOM   2674 H HA   . ASP A 1 176 ? -22.82662 -32.22299 14.07439  1.000 34.76070  ? 176 ASP A HA   1 
ATOM   2675 H HB2  . ASP A 1 176 ? -24.77612 -32.90987 15.04652  1.000 37.02736  ? 176 ASP A HB2  1 
ATOM   2676 H HB3  . ASP A 1 176 ? -24.91992 -31.38281 14.63080  1.000 37.02736  ? 176 ASP A HB3  1 
ATOM   2677 N N    . LEU A 1 177 ? -23.35309 -34.82957 13.66152  1.000 26.42937  ? 177 LEU A N    1 
ATOM   2678 C CA   . LEU A 1 177 ? -23.02696 -36.15218 13.11124  1.000 27.31229  ? 177 LEU A CA   1 
ATOM   2679 C C    . LEU A 1 177 ? -24.23433 -36.84897 12.49162  1.000 30.32173  ? 177 LEU A C    1 
ATOM   2680 O O    . LEU A 1 177 ? -24.09170 -37.99047 12.00637  1.000 30.92923  ? 177 LEU A O    1 
ATOM   2681 C CB   . LEU A 1 177 ? -22.37208 -37.03558 14.17190  1.000 28.66562  ? 177 LEU A CB   1 
ATOM   2682 C CG   . LEU A 1 177 ? -20.84250 -36.95458 14.21871  1.000 32.90165  ? 177 LEU A CG   1 
ATOM   2683 C CD1  . LEU A 1 177 ? -20.19671 -37.56544 12.92827  1.000 29.56842  ? 177 LEU A CD1  1 
ATOM   2684 C CD2  . LEU A 1 177 ? -20.32052 -35.50971 14.48033  1.000 31.12306  ? 177 LEU A CD2  1 
ATOM   2685 H H    . LEU A 1 177 ? -23.52681 -34.80402 14.50340  1.000 31.76935  ? 177 LEU A H    1 
ATOM   2686 H HA   . LEU A 1 177 ? -22.36886 -36.03949 12.40760  1.000 32.82885  ? 177 LEU A HA   1 
ATOM   2687 H HB2  . LEU A 1 177 ? -22.70600 -36.76905 15.04275  1.000 34.45285  ? 177 LEU A HB2  1 
ATOM   2688 H HB3  . LEU A 1 177 ? -22.61089 -37.95860 13.99329  1.000 34.45285  ? 177 LEU A HB3  1 
ATOM   2689 H HG   . LEU A 1 177 ? -20.55443 -37.48825 14.97575  1.000 39.53608  ? 177 LEU A HG   1 
ATOM   2690 H HD11 . LEU A 1 177 ? -20.89311 -37.72654 12.27255  1.000 35.53620  ? 177 LEU A HD11 1 
ATOM   2691 H HD12 . LEU A 1 177 ? -19.54681 -36.93886 12.57343  1.000 35.53620  ? 177 LEU A HD12 1 
ATOM   2692 H HD13 . LEU A 1 177 ? -19.75977 -38.40025 13.15864  1.000 35.53620  ? 177 LEU A HD13 1 
ATOM   2693 H HD21 . LEU A 1 177 ? -20.92092 -35.06408 15.09826  1.000 37.40177  ? 177 LEU A HD21 1 
ATOM   2694 H HD22 . LEU A 1 177 ? -19.43028 -35.55987 14.86225  1.000 37.40177  ? 177 LEU A HD22 1 
ATOM   2695 H HD23 . LEU A 1 177 ? -20.29302 -35.02679 13.63954  1.000 37.40177  ? 177 LEU A HD23 1 
ATOM   2696 N N    . GLU A 1 178 ? -25.40943 -36.21777 12.50406  1.000 27.87792  ? 178 GLU A N    1 
ATOM   2697 C CA   . GLU A 1 178 ? -26.52465 -36.58412 11.62174  1.000 30.66025  ? 178 GLU A CA   1 
ATOM   2698 C C    . GLU A 1 178 ? -26.50347 -35.83042 10.29944  1.000 28.08251  ? 178 GLU A C    1 
ATOM   2699 O O    . GLU A 1 178 ? -27.40912 -36.00670 9.48148   1.000 30.73173  ? 178 GLU A O    1 
ATOM   2700 C CB   . GLU A 1 178 ? -27.86455 -36.36648 12.33810  1.000 33.40251  ? 178 GLU A CB   1 
ATOM   2701 C CG   . GLU A 1 178 ? -28.06654 -37.34238 13.51143  1.000 38.16579  ? 178 GLU A CG   1 
ATOM   2702 C CD   . GLU A 1 178 ? -29.34917 -37.07230 14.27566  1.000 46.25762  ? 178 GLU A CD   1 
ATOM   2703 O OE1  . GLU A 1 178 ? -29.90921 -35.96632 14.11001  1.000 47.11921  ? 178 GLU A OE1  1 
ATOM   2704 O OE2  . GLU A 1 178 ? -29.77384 -37.94945 15.04765  1.000 55.12931  ? 178 GLU A OE2  1 
ATOM   2705 H H    . GLU A 1 178 ? -25.59156 -35.55877 13.02573  1.000 33.50760  ? 178 GLU A H    1 
ATOM   2706 H HA   . GLU A 1 178 ? -26.46122 -37.53003 11.41646  1.000 36.84640  ? 178 GLU A HA   1 
ATOM   2707 H HB2  . GLU A 1 178 ? -27.89367 -35.46250 12.68863  1.000 40.13711  ? 178 GLU A HB2  1 
ATOM   2708 H HB3  . GLU A 1 178 ? -28.58777 -36.50056 11.70574  1.000 40.13711  ? 178 GLU A HB3  1 
ATOM   2709 H HG2  . GLU A 1 178 ? -28.10605 -38.24842 13.16730  1.000 45.85305  ? 178 GLU A HG2  1 
ATOM   2710 H HG3  . GLU A 1 178 ? -27.32371 -37.25415 14.12895  1.000 45.85305  ? 178 GLU A HG3  1 
ATOM   2711 N N    . GLY A 1 179 ? -25.50832 -34.97193 10.06530  1.000 28.93527  ? 179 GLY A N    1 
ATOM   2712 C CA   . GLY A 1 179 ? -25.33373 -34.31320 8.78153   1.000 28.24188  ? 179 GLY A CA   1 
ATOM   2713 C C    . GLY A 1 179 ? -26.13595 -33.05838 8.56529   1.000 29.35217  ? 179 GLY A C    1 
ATOM   2714 O O    . GLY A 1 179 ? -26.15295 -32.52613 7.44544   1.000 28.24748  ? 179 GLY A O    1 
ATOM   2715 H H    . GLY A 1 179 ? -24.91365 -34.75400 10.64708  1.000 34.77643  ? 179 GLY A H    1 
ATOM   2716 H HA2  . GLY A 1 179 ? -24.39744 -34.07970 8.68292   1.000 33.94436  ? 179 GLY A HA2  1 
ATOM   2717 H HA3  . GLY A 1 179 ? -25.57868 -34.93850 8.08160   1.000 33.94436  ? 179 GLY A HA3  1 
ATOM   2718 N N    . ASN A 1 180 ? -26.73807 -32.51237 9.62612   1.000 29.34651  ? 180 ASN A N    1 
ATOM   2719 C CA   . ASN A 1 180 ? -27.40412 -31.22991 9.55849   1.000 30.57526  ? 180 ASN A CA   1 
ATOM   2720 C C    . ASN A 1 180 ? -26.41910 -30.12118 9.86396   1.000 27.24600  ? 180 ASN A C    1 
ATOM   2721 O O    . ASN A 1 180 ? -25.83464 -30.09422 10.94914  1.000 30.89745  ? 180 ASN A O    1 
ATOM   2722 C CB   . ASN A 1 180 ? -28.54314 -31.18203 10.56828  1.000 29.39418  ? 180 ASN A CB   1 
ATOM   2723 C CG   . ASN A 1 180 ? -29.55598 -32.25065 10.32063  1.000 33.12765  ? 180 ASN A CG   1 
ATOM   2724 O OD1  . ASN A 1 180 ? -30.17985 -32.27758 9.26222   1.000 39.12892  ? 180 ASN A OD1  1 
ATOM   2725 N ND2  . ASN A 1 180 ? -29.65448 -33.19854 11.25241  1.000 36.79949  ? 180 ASN A ND2  1 
ATOM   2726 H H    . ASN A 1 180 ? -26.76941 -32.87876 10.40353  1.000 35.26991  ? 180 ASN A H    1 
ATOM   2727 H HA   . ASN A 1 180 ? -27.75139 -31.10095 8.66202   1.000 36.74441  ? 180 ASN A HA   1 
ATOM   2728 H HB2  . ASN A 1 180 ? -28.18368 -31.30609 11.46064  1.000 35.32712  ? 180 ASN A HB2  1 
ATOM   2729 H HB3  . ASN A 1 180 ? -28.98824 -30.32240 10.50647  1.000 35.32712  ? 180 ASN A HB3  1 
ATOM   2730 H HD21 . ASN A 1 180 ? -30.22267 -33.83714 11.15778  1.000 44.21349  ? 180 ASN A HD21 1 
ATOM   2731 H HD22 . ASN A 1 180 ? -29.14985 -33.17157 11.94826  1.000 44.21349  ? 180 ASN A HD22 1 
ATOM   2732 N N    . PHE A 1 181 ? -26.25415 -29.21718 8.92797   1.000 29.25537  ? 181 PHE A N    1 
ATOM   2733 C CA   . PHE A 1 181 ? -25.41920 -28.04594 9.16899   1.000 28.93998  ? 181 PHE A CA   1 
ATOM   2734 C C    . PHE A 1 181 ? -25.84147 -27.29915 10.42566  1.000 29.06906  ? 181 PHE A C    1 
ATOM   2735 O O    . PHE A 1 181 ? -27.02091 -27.17408 10.72335  1.000 29.86249  ? 181 PHE A O    1 
ATOM   2736 C CB   . PHE A 1 181 ? -25.48935 -27.10473 7.97416   1.000 27.27657  ? 181 PHE A CB   1 
ATOM   2737 C CG   . PHE A 1 181 ? -24.40726 -27.32870 6.99820   1.000 30.96707  ? 181 PHE A CG   1 
ATOM   2738 C CD1  . PHE A 1 181 ? -23.16055 -26.73077 7.16496   1.000 29.95739  ? 181 PHE A CD1  1 
ATOM   2739 C CD2  . PHE A 1 181 ? -24.60684 -28.16980 5.91189   1.000 32.22914  ? 181 PHE A CD2  1 
ATOM   2740 C CE1  . PHE A 1 181 ? -22.13252 -26.97432 6.27302   1.000 29.76509  ? 181 PHE A CE1  1 
ATOM   2741 C CE2  . PHE A 1 181 ? -23.59496 -28.40802 5.00825   1.000 30.29747  ? 181 PHE A CE2  1 
ATOM   2742 C CZ   . PHE A 1 181 ? -22.35727 -27.81600 5.18230   1.000 31.26104  ? 181 PHE A CZ   1 
ATOM   2743 H H    . PHE A 1 181 ? -26.60896 -29.24966 8.14525   1.000 35.16054  ? 181 PHE A H    1 
ATOM   2744 H HA   . PHE A 1 181 ? -24.50375 -28.34237 9.29137   1.000 34.78208  ? 181 PHE A HA   1 
ATOM   2745 H HB2  . PHE A 1 181 ? -26.33526 -27.23748 7.51840   1.000 32.78599  ? 181 PHE A HB2  1 
ATOM   2746 H HB3  . PHE A 1 181 ? -25.42261 -26.19001 8.28994   1.000 32.78599  ? 181 PHE A HB3  1 
ATOM   2747 H HD1  . PHE A 1 181 ? -23.01769 -26.16038 7.88548   1.000 36.00297  ? 181 PHE A HD1  1 
ATOM   2748 H HD2  . PHE A 1 181 ? -25.43417 -28.57754 5.79280   1.000 38.72907  ? 181 PHE A HD2  1 
ATOM   2749 H HE1  . PHE A 1 181 ? -21.29915 -26.58109 6.39856   1.000 35.77220  ? 181 PHE A HE1  1 
ATOM   2750 H HE2  . PHE A 1 181 ? -23.74416 -28.96746 4.28046   1.000 36.41107  ? 181 PHE A HE2  1 
ATOM   2751 H HZ   . PHE A 1 181 ? -21.67435 -27.97871 4.57234   1.000 37.56735  ? 181 PHE A HZ   1 
ATOM   2752 N N    . TYR A 1 182 ? -24.85188 -26.82108 11.15894  1.000 30.28997  ? 182 TYR A N    1 
ATOM   2753 C CA   . TYR A 1 182 ? -25.04063 -25.68148 12.02132  1.000 27.49060  ? 182 TYR A CA   1 
ATOM   2754 C C    . TYR A 1 182 ? -25.14087 -24.43133 11.15320  1.000 28.38706  ? 182 TYR A C    1 
ATOM   2755 O O    . TYR A 1 182 ? -24.25174 -24.15654 10.34326  1.000 29.81521  ? 182 TYR A O    1 
ATOM   2756 C CB   . TYR A 1 182 ? -23.87522 -25.59678 12.99415  1.000 23.99507  ? 182 TYR A CB   1 
ATOM   2757 C CG   . TYR A 1 182 ? -23.84408 -26.72252 14.00978  1.000 28.21948  ? 182 TYR A CG   1 
ATOM   2758 C CD1  . TYR A 1 182 ? -24.59565 -26.66372 15.16967  1.000 27.77064  ? 182 TYR A CD1  1 
ATOM   2759 C CD2  . TYR A 1 182 ? -22.99871 -27.78359 13.84707  1.000 28.75359  ? 182 TYR A CD2  1 
ATOM   2760 C CE1  . TYR A 1 182 ? -24.54974 -27.66828 16.09366  1.000 31.08340  ? 182 TYR A CE1  1 
ATOM   2761 C CE2  . TYR A 1 182 ? -22.93167 -28.79828 14.77416  1.000 27.69163  ? 182 TYR A CE2  1 
ATOM   2762 C CZ   . TYR A 1 182 ? -23.70075 -28.74820 15.89111  1.000 25.43406  ? 182 TYR A CZ   1 
ATOM   2763 O OH   . TYR A 1 182 ? -23.61055 -29.75959 16.81478  1.000 26.29337  ? 182 TYR A OH   1 
ATOM   2764 H H    . TYR A 1 182 ? -24.05522 -27.14472 11.17230  1.000 36.40206  ? 182 TYR A H    1 
ATOM   2765 H HA   . TYR A 1 182 ? -25.85656 -25.76051 12.53988  1.000 33.04282  ? 182 TYR A HA   1 
ATOM   2766 H HB2  . TYR A 1 182 ? -23.04633 -25.62865 12.49133  1.000 28.84819  ? 182 TYR A HB2  1 
ATOM   2767 H HB3  . TYR A 1 182 ? -23.93580 -24.76015 13.48127  1.000 28.84819  ? 182 TYR A HB3  1 
ATOM   2768 H HD1  . TYR A 1 182 ? -25.14197 -25.92688 15.32297  1.000 33.37887  ? 182 TYR A HD1  1 
ATOM   2769 H HD2  . TYR A 1 182 ? -22.45627 -27.82087 13.09257  1.000 34.55841  ? 182 TYR A HD2  1 
ATOM   2770 H HE1  . TYR A 1 182 ? -25.08388 -27.62932 16.85397  1.000 37.35418  ? 182 TYR A HE1  1 
ATOM   2771 H HE2  . TYR A 1 182 ? -22.35947 -29.51814 14.63530  1.000 33.28406  ? 182 TYR A HE2  1 
ATOM   2772 H HH   . TYR A 1 182 ? -22.91025 -30.20509 16.68553  1.000 31.60615  ? 182 TYR A HH   1 
ATOM   2773 N N    . GLY A 1 183 ? -26.23586 -23.67406 11.30474  1.000 30.27044  ? 183 GLY A N    1 
ATOM   2774 C CA   . GLY A 1 183 ? -26.43110 -22.45931 10.54910  1.000 28.80488  ? 183 GLY A CA   1 
ATOM   2775 C C    . GLY A 1 183 ? -27.07002 -22.62687 9.17415   1.000 35.25132  ? 183 GLY A C    1 
ATOM   2776 O O    . GLY A 1 183 ? -27.42392 -23.73170 8.73352   1.000 33.55805  ? 183 GLY A O    1 
ATOM   2777 H H    . GLY A 1 183 ? -26.87831 -23.85517 11.84701  1.000 36.37863  ? 183 GLY A H    1 
ATOM   2778 H HA2  . GLY A 1 183 ? -26.99983 -21.86526 11.06344  1.000 34.61996  ? 183 GLY A HA2  1 
ATOM   2779 H HA3  . GLY A 1 183 ? -25.56808 -22.03605 10.41895  1.000 34.61996  ? 183 GLY A HA3  1 
ATOM   2780 N N    . PRO A 1 184 ? -27.17310 -21.51047 8.46405   1.000 30.69757  ? 184 PRO A N    1 
ATOM   2781 C CA   . PRO A 1 184 ? -27.91616 -21.45658 7.18960   1.000 33.31477  ? 184 PRO A CA   1 
ATOM   2782 C C    . PRO A 1 184 ? -27.09960 -21.84260 5.96154   1.000 43.68484  ? 184 PRO A C    1 
ATOM   2783 O O    . PRO A 1 184 ? -27.22208 -21.22922 4.89905   1.000 51.44009  ? 184 PRO A O    1 
ATOM   2784 C CB   . PRO A 1 184 ? -28.30191 -19.96985 7.10698   1.000 38.10009  ? 184 PRO A CB   1 
ATOM   2785 C CG   . PRO A 1 184 ? -27.10038 -19.29658 7.71456   1.000 38.50895  ? 184 PRO A CG   1 
ATOM   2786 C CD   . PRO A 1 184 ? -26.68063 -20.17714 8.86366   1.000 37.45980  ? 184 PRO A CD   1 
ATOM   2787 H HA   . PRO A 1 184 ? -28.69131 -22.03683 7.24749   1.000 40.03183  ? 184 PRO A HA   1 
ATOM   2788 H HB2  . PRO A 1 184 ? -28.43322 -19.70180 6.18405   1.000 45.77421  ? 184 PRO A HB2  1 
ATOM   2789 H HB3  . PRO A 1 184 ? -29.10643 -19.79664 7.62043   1.000 45.77421  ? 184 PRO A HB3  1 
ATOM   2790 H HG2  . PRO A 1 184 ? -26.39248 -19.23050 7.05470   1.000 46.26484  ? 184 PRO A HG2  1 
ATOM   2791 H HG3  . PRO A 1 184 ? -27.34401 -18.41205 8.02946   1.000 46.26484  ? 184 PRO A HG3  1 
ATOM   2792 H HD2  . PRO A 1 184 ? -25.71564 -20.18034 8.96203   1.000 45.00586  ? 184 PRO A HD2  1 
ATOM   2793 H HD3  . PRO A 1 184 ? -27.09745 -19.88832 9.69056   1.000 45.00586  ? 184 PRO A HD3  1 
ATOM   2794 N N    . PHE A 1 185 ? -26.24510 -22.83035 6.08964   1.000 34.70232  ? 185 PHE A N    1 
ATOM   2795 C CA   . PHE A 1 185 ? -25.27133 -23.16175 5.05629   1.000 34.90845  ? 185 PHE A CA   1 
ATOM   2796 C C    . PHE A 1 185 ? -25.66899 -24.43195 4.31557   1.000 30.37594  ? 185 PHE A C    1 
ATOM   2797 O O    . PHE A 1 185 ? -26.39696 -25.29522 4.83888   1.000 30.44075  ? 185 PHE A O    1 
ATOM   2798 C CB   . PHE A 1 185 ? -23.86849 -23.29746 5.68721   1.000 32.76832  ? 185 PHE A CB   1 
ATOM   2799 C CG   . PHE A 1 185 ? -23.50592 -22.12724 6.55928   1.000 29.20638  ? 185 PHE A CG   1 
ATOM   2800 C CD1  . PHE A 1 185 ? -23.32291 -20.87234 6.01058   1.000 34.23513  ? 185 PHE A CD1  1 
ATOM   2801 C CD2  . PHE A 1 185 ? -23.40312 -22.27554 7.92958   1.000 31.55488  ? 185 PHE A CD2  1 
ATOM   2802 C CE1  . PHE A 1 185 ? -23.03365 -19.75193 6.81811   1.000 31.90171  ? 185 PHE A CE1  1 
ATOM   2803 C CE2  . PHE A 1 185 ? -23.11736 -21.16712 8.73820   1.000 31.10263  ? 185 PHE A CE2  1 
ATOM   2804 C CZ   . PHE A 1 185 ? -22.92963 -19.92355 8.18794   1.000 30.14449  ? 185 PHE A CZ   1 
ATOM   2805 H H    . PHE A 1 185 ? -26.20240 -23.34068 6.78054   1.000 41.69689  ? 185 PHE A H    1 
ATOM   2806 H HA   . PHE A 1 185 ? -25.24056 -22.46027 4.38704   1.000 41.94425  ? 185 PHE A HA   1 
ATOM   2807 H HB2  . PHE A 1 185 ? -23.84463 -24.09815 6.23423   1.000 39.37608  ? 185 PHE A HB2  1 
ATOM   2808 H HB3  . PHE A 1 185 ? -23.20864 -23.35975 4.97896   1.000 39.37608  ? 185 PHE A HB3  1 
ATOM   2809 H HD1  . PHE A 1 185 ? -23.39185 -20.76387 5.08950   1.000 41.13626  ? 185 PHE A HD1  1 
ATOM   2810 H HD2  . PHE A 1 185 ? -23.52387 -23.11283 8.31593   1.000 37.91995  ? 185 PHE A HD2  1 
ATOM   2811 H HE1  . PHE A 1 185 ? -22.91485 -18.91219 6.43650   1.000 38.33616  ? 185 PHE A HE1  1 
ATOM   2812 H HE2  . PHE A 1 185 ? -23.05407 -21.27548 9.65969   1.000 37.37726  ? 185 PHE A HE2  1 
ATOM   2813 H HZ   . PHE A 1 185 ? -22.73285 -19.19735 8.73459   1.000 36.22749  ? 185 PHE A HZ   1 
ATOM   2814 N N    . VAL A 1 186 ? -25.18370 -24.50700 3.06739   1.000 32.82406  ? 186 VAL A N    1 
ATOM   2815 C CA   . VAL A 1 186 ? -25.36315 -25.64731 2.17172   1.000 29.18347  ? 186 VAL A CA   1 
ATOM   2816 C C    . VAL A 1 186 ? -23.97914 -26.08246 1.69084   1.000 29.98262  ? 186 VAL A C    1 
ATOM   2817 O O    . VAL A 1 186 ? -23.07983 -25.24983 1.53015   1.000 31.81876  ? 186 VAL A O    1 
ATOM   2818 C CB   . VAL A 1 186 ? -26.25682 -25.31021 0.95772   1.000 34.01937  ? 186 VAL A CB   1 
ATOM   2819 C CG1  . VAL A 1 186 ? -27.70215 -24.99314 1.41439   1.000 36.19565  ? 186 VAL A CG1  1 
ATOM   2820 C CG2  . VAL A 1 186 ? -25.67162 -24.16212 0.11476   1.000 33.70508  ? 186 VAL A CG2  1 
ATOM   2821 H H    . VAL A 1 186 ? -24.72555 -23.87633 2.70414   1.000 39.44297  ? 186 VAL A H    1 
ATOM   2822 H HA   . VAL A 1 186 ? -25.78351 -26.37243 2.65999   1.000 35.07426  ? 186 VAL A HA   1 
ATOM   2823 H HB   . VAL A 1 186 ? -26.28799 -26.09050 0.38234   1.000 40.87735  ? 186 VAL A HB   1 
ATOM   2824 H HG11 . VAL A 1 186 ? -28.30275 -25.10295 0.66065   1.000 43.48888  ? 186 VAL A HG11 1 
ATOM   2825 H HG12 . VAL A 1 186 ? -27.94958 -25.60387 2.12621   1.000 43.48888  ? 186 VAL A HG12 1 
ATOM   2826 H HG13 . VAL A 1 186 ? -27.73836 -24.07862 1.73570   1.000 43.48888  ? 186 VAL A HG13 1 
ATOM   2827 H HG21 . VAL A 1 186 ? -26.28461 -23.95717 -0.60853  1.000 40.50020  ? 186 VAL A HG21 1 
ATOM   2828 H HG22 . VAL A 1 186 ? -25.55498 -23.38275 0.68034   1.000 40.50020  ? 186 VAL A HG22 1 
ATOM   2829 H HG23 . VAL A 1 186 ? -24.81525 -24.44006 -0.24616  1.000 40.50020  ? 186 VAL A HG23 1 
ATOM   2830 N N    . ASP A 1 187 ? -23.82044 -27.38924 1.41217   1.000 28.93220  ? 187 ASP A N    1 
ATOM   2831 C CA   . ASP A 1 187 ? -22.54776 -27.87815 0.89039   1.000 26.97390  ? 187 ASP A CA   1 
ATOM   2832 C C    . ASP A 1 187 ? -22.49497 -27.74079 -0.62738  1.000 30.96875  ? 187 ASP A C    1 
ATOM   2833 O O    . ASP A 1 187 ? -22.58221 -28.71338 -1.38241  1.000 34.16697  ? 187 ASP A O    1 
ATOM   2834 C CB   . ASP A 1 187 ? -22.26622 -29.31369 1.33737   1.000 24.62066  ? 187 ASP A CB   1 
ATOM   2835 C CG   . ASP A 1 187 ? -23.43473 -30.27232 1.15478   1.000 30.04602  ? 187 ASP A CG   1 
ATOM   2836 O OD1  . ASP A 1 187 ? -24.61190 -29.86891 0.92115   1.000 32.86116  ? 187 ASP A OD1  1 
ATOM   2837 O OD2  . ASP A 1 187 ? -23.14204 -31.48212 1.27181   1.000 29.42806  ? 187 ASP A OD2  1 
ATOM   2838 H H    . ASP A 1 187 ? -24.42541 -27.99139 1.51710   1.000 34.77274  ? 187 ASP A H    1 
ATOM   2839 H HA   . ASP A 1 187 ? -21.85894 -27.30134 1.25606   1.000 32.42278  ? 187 ASP A HA   1 
ATOM   2840 H HB2  . ASP A 1 187 ? -21.52152 -29.65837 0.82014   1.000 29.59889  ? 187 ASP A HB2  1 
ATOM   2841 H HB3  . ASP A 1 187 ? -22.03942 -29.30524 2.28045   1.000 29.59889  ? 187 ASP A HB3  1 
ATOM   2842 N N    . ARG A 1 188 ? -22.26905 -26.50166 -1.07311  1.000 31.96610  ? 188 ARG A N    1 
ATOM   2843 C CA   . ARG A 1 188 ? -21.98274 -26.14495 -2.46553  1.000 30.05752  ? 188 ARG A CA   1 
ATOM   2844 C C    . ARG A 1 188 ? -20.96581 -25.02342 -2.43465  1.000 34.49150  ? 188 ARG A C    1 
ATOM   2845 O O    . ARG A 1 188 ? -21.00024 -24.17450 -1.54025  1.000 32.09677  ? 188 ARG A O    1 
ATOM   2846 C CB   . ARG A 1 188 ? -23.24427 -25.63025 -3.21267  1.000 37.48852  ? 188 ARG A CB   1 
ATOM   2847 H H    . ARG A 1 188 ? -22.27664 -25.81194 -0.55948  1.000 38.41342  ? 188 ARG A H    1 
ATOM   2848 H HA   . ARG A 1 188 ? -21.64102 -26.91797 -2.94153  1.000 36.12312  ? 188 ARG A HA   1 
ATOM   2849 N N    . GLN A 1 189 ? -20.09264 -24.99449 -3.44527  1.000 32.86669  ? 189 GLN A N    1 
ATOM   2850 C CA   . GLN A 1 189 ? -19.03397 -23.99552 -3.49079  1.000 37.06410  ? 189 GLN A CA   1 
ATOM   2851 C C    . GLN A 1 189 ? -19.58421 -22.74464 -4.15146  1.000 37.60396  ? 189 GLN A C    1 
ATOM   2852 O O    . GLN A 1 189 ? -19.33450 -22.44218 -5.32018  1.000 40.12461  ? 189 GLN A O    1 
ATOM   2853 C CB   . GLN A 1 189 ? -17.82001 -24.53011 -4.22110  1.000 40.92912  ? 189 GLN A CB   1 
ATOM   2854 C CG   . GLN A 1 189 ? -16.54696 -24.11064 -3.58387  1.000 43.52543  ? 189 GLN A CG   1 
ATOM   2855 C CD   . GLN A 1 189 ? -15.46661 -25.04608 -3.98425  1.000 47.32441  ? 189 GLN A CD   1 
ATOM   2856 O OE1  . GLN A 1 189 ? -15.16107 -25.99076 -3.26684  1.000 41.69204  ? 189 GLN A OE1  1 
ATOM   2857 N NE2  . GLN A 1 189 ? -14.93978 -24.84923 -5.18674  1.000 49.46528  ? 189 GLN A NE2  1 
ATOM   2858 H H    . GLN A 1 189 ? -20.09663 -25.54093 -4.10933  1.000 39.49413  ? 189 GLN A H    1 
ATOM   2859 H HA   . GLN A 1 189 ? -18.76796 -23.77491 -2.58444  1.000 44.53102  ? 189 GLN A HA   1 
ATOM   2860 H HB2  . GLN A 1 189 ? -17.85207 -25.49958 -4.22217  1.000 49.16904  ? 189 GLN A HB2  1 
ATOM   2861 H HB3  . GLN A 1 189 ? -17.82582 -24.19697 -5.13208  1.000 49.16904  ? 189 GLN A HB3  1 
ATOM   2862 H HG2  . GLN A 1 189 ? -16.31207 -23.21576 -3.87527  1.000 52.28462  ? 189 GLN A HG2  1 
ATOM   2863 H HG3  . GLN A 1 189 ? -16.63936 -24.13165 -2.61851  1.000 52.28462  ? 189 GLN A HG3  1 
ATOM   2864 H HE21 . GLN A 1 189 ? -15.22808 -24.20867 -5.68290  1.000 59.41243  ? 189 GLN A HE21 1 
ATOM   2865 H HE22 . GLN A 1 189 ? -14.31019 -25.36226 -5.46960  1.000 59.41243  ? 189 GLN A HE22 1 
ATOM   2866 N N    . THR A 1 190 ? -20.36028 -22.00976 -3.35785  1.000 34.37646  ? 190 THR A N    1 
ATOM   2867 C CA   . THR A 1 190 ? -20.92515 -20.72816 -3.73972  1.000 36.31776  ? 190 THR A CA   1 
ATOM   2868 C C    . THR A 1 190 ? -20.78445 -19.80513 -2.53821  1.000 40.70960  ? 190 THR A C    1 
ATOM   2869 O O    . THR A 1 190 ? -20.66059 -20.25376 -1.38749  1.000 38.52188  ? 190 THR A O    1 
ATOM   2870 C CB   . THR A 1 190 ? -22.37755 -20.90979 -4.22409  1.000 43.20823  ? 190 THR A CB   1 
ATOM   2871 O OG1  . THR A 1 190 ? -22.87350 -19.67394 -4.74810  1.000 48.17374  ? 190 THR A OG1  1 
ATOM   2872 C CG2  . THR A 1 190 ? -23.28368 -21.40787 -3.09319  1.000 40.97592  ? 190 THR A CG2  1 
ATOM   2873 H H    . THR A 1 190 ? -20.58073 -22.24586 -2.56081  1.000 41.30585  ? 190 THR A H    1 
ATOM   2874 H HA   . THR A 1 190 ? -20.45112 -20.30475 -4.47247  1.000 43.63541  ? 190 THR A HA   1 
ATOM   2875 H HB   . THR A 1 190 ? -22.39666 -21.57955 -4.92549  1.000 51.90397  ? 190 THR A HB   1 
ATOM   2876 H HG1  . THR A 1 190 ? -23.68154 -19.75636 -4.96229  1.000 57.86259  ? 190 THR A HG1  1 
ATOM   2877 H HG21 . THR A 1 190 ? -22.79704 -22.02638 -2.52615  1.000 49.22521  ? 190 THR A HG21 1 
ATOM   2878 H HG22 . THR A 1 190 ? -23.58557 -20.65895 -2.55571  1.000 49.22521  ? 190 THR A HG22 1 
ATOM   2879 H HG23 . THR A 1 190 ? -24.05697 -21.86179 -3.46317  1.000 49.22521  ? 190 THR A HG23 1 
ATOM   2880 N N    . ALA A 1 191 ? -20.77619 -18.49965 -2.81396  1.000 39.21787  ? 191 ALA A N    1 
ATOM   2881 C CA   . ALA A 1 191 ? -20.61767 -17.50496 -1.76143  1.000 40.21563  ? 191 ALA A CA   1 
ATOM   2882 C C    . ALA A 1 191 ? -21.77961 -17.59219 -0.78543  1.000 40.74010  ? 191 ALA A C    1 
ATOM   2883 O O    . ALA A 1 191 ? -22.94354 -17.65452 -1.19931  1.000 43.84168  ? 191 ALA A O    1 
ATOM   2884 C CB   . ALA A 1 191 ? -20.54007 -16.10263 -2.37495  1.000 47.91511  ? 191 ALA A CB   1 
ATOM   2885 H H    . ALA A 1 191 ? -20.86068 -18.16714 -3.60257  1.000 47.11555  ? 191 ALA A H    1 
ATOM   2886 H HA   . ALA A 1 191 ? -19.79391 -17.66878 -1.27616  1.000 48.31286  ? 191 ALA A HA   1 
ATOM   2887 H HB1  . ALA A 1 191 ? -19.80444 -16.07454 -3.00658  1.000 57.55223  ? 191 ALA A HB1  1 
ATOM   2888 H HB2  . ALA A 1 191 ? -21.37466 -15.91058 -2.83044  1.000 57.55223  ? 191 ALA A HB2  1 
ATOM   2889 H HB3  . ALA A 1 191 ? -20.39314 -15.45592 -1.66708  1.000 57.55223  ? 191 ALA A HB3  1 
ATOM   2890 N N    . GLN A 1 192 ? -21.46716 -17.62969 0.51768   1.000 37.86419  ? 192 GLN A N    1 
ATOM   2891 C CA   . GLN A 1 192 ? -22.49079 -17.78826 1.53508   1.000 37.31873  ? 192 GLN A CA   1 
ATOM   2892 C C    . GLN A 1 192 ? -22.18552 -16.92192 2.74490   1.000 39.22993  ? 192 GLN A C    1 
ATOM   2893 O O    . GLN A 1 192 ? -21.04614 -16.87514 3.21593   1.000 37.89693  ? 192 GLN A O    1 
ATOM   2894 C CB   . GLN A 1 192 ? -22.61455 -19.24267 1.99402   1.000 33.95855  ? 192 GLN A CB   1 
ATOM   2895 C CG   . GLN A 1 192 ? -23.08140 -20.13838 0.89491   1.000 31.88470  ? 192 GLN A CG   1 
ATOM   2896 C CD   . GLN A 1 192 ? -23.10477 -21.58474 1.27462   1.000 34.49861  ? 192 GLN A CD   1 
ATOM   2897 O OE1  . GLN A 1 192 ? -23.77178 -21.97452 2.22444   1.000 30.29746  ? 192 GLN A OE1  1 
ATOM   2898 N NE2  . GLN A 1 192 ? -22.39540 -22.40458 0.51285   1.000 33.98934  ? 192 GLN A NE2  1 
ATOM   2899 H H    . GLN A 1 192 ? -20.66751 -17.56461 0.82739   1.000 45.49113  ? 192 GLN A H    1 
ATOM   2900 H HA   . GLN A 1 192 ? -23.33520 -17.49697 1.15690   1.000 44.83657  ? 192 GLN A HA   1 
ATOM   2901 H HB2  . GLN A 1 192 ? -21.74727 -19.55691 2.29397   1.000 40.80436  ? 192 GLN A HB2  1 
ATOM   2902 H HB3  . GLN A 1 192 ? -23.25542 -19.29404 2.72034   1.000 40.80436  ? 192 GLN A HB3  1 
ATOM   2903 H HG2  . GLN A 1 192 ? -23.98279 -19.88272 0.64385   1.000 38.31574  ? 192 GLN A HG2  1 
ATOM   2904 H HG3  . GLN A 1 192 ? -22.48520 -20.04022 0.13610   1.000 38.31574  ? 192 GLN A HG3  1 
ATOM   2905 H HE21 . GLN A 1 192 ? -21.95458 -22.09513 -0.15762  1.000 40.84131  ? 192 GLN A HE21 1 
ATOM   2906 H HE22 . GLN A 1 192 ? -22.37579 -23.24614 0.68888   1.000 40.84131  ? 192 GLN A HE22 1 
ATOM   2907 N N    . ALA A 1 193 ? -23.21642 -16.27918 3.26551   1.000 38.53621  ? 193 ALA A N    1 
ATOM   2908 C CA   . ALA A 1 193 ? -23.05554 -15.30892 4.34112   1.000 41.97668  ? 193 ALA A CA   1 
ATOM   2909 C C    . ALA A 1 193 ? -23.47418 -15.93565 5.65920   1.000 34.77448  ? 193 ALA A C    1 
ATOM   2910 O O    . ALA A 1 193 ? -24.48587 -16.64467 5.73931   1.000 39.22572  ? 193 ALA A O    1 
ATOM   2911 C CB   . ALA A 1 193 ? -23.89188 -14.05144 4.08480   1.000 47.47418  ? 193 ALA A CB   1 
ATOM   2912 H H    . ALA A 1 193 ? -24.03081 -16.38733 3.01121   1.000 46.29755  ? 193 ALA A H    1 
ATOM   2913 H HA   . ALA A 1 193 ? -22.12384 -15.04505 4.39778   1.000 50.42612  ? 193 ALA A HA   1 
ATOM   2914 H HB1  . ALA A 1 193 ? -23.81142 -13.45773 4.84765   1.000 57.02311  ? 193 ALA A HB1  1 
ATOM   2915 H HB2  . ALA A 1 193 ? -23.56238 -13.61038 3.28618   1.000 57.02311  ? 193 ALA A HB2  1 
ATOM   2916 H HB3  . ALA A 1 193 ? -24.81912 -14.30846 3.96204   1.000 57.02311  ? 193 ALA A HB3  1 
ATOM   2917 N N    . ALA A 1 194 ? -22.71906 -15.63406 6.71543   1.000 36.47170  ? 194 ALA A N    1 
ATOM   2918 C CA   . ALA A 1 194 ? -23.07437 -16.04663 8.06304   1.000 38.14931  ? 194 ALA A CA   1 
ATOM   2919 C C    . ALA A 1 194 ? -23.83010 -14.97733 8.84703   1.000 45.92182  ? 194 ALA A C    1 
ATOM   2920 O O    . ALA A 1 194 ? -24.46104 -15.28959 9.86255   1.000 39.76985  ? 194 ALA A O    1 
ATOM   2921 C CB   . ALA A 1 194 ? -21.79026 -16.44015 8.81559   1.000 43.74746  ? 194 ALA A CB   1 
ATOM   2922 H H    . ALA A 1 194 ? -21.98687 -15.18501 6.67228   1.000 43.82014  ? 194 ALA A H    1 
ATOM   2923 H HA   . ALA A 1 194 ? -23.65564 -16.82232 8.02649   1.000 45.83327  ? 194 ALA A HA   1 
ATOM   2924 H HB1  . ALA A 1 194 ? -21.99591 -16.54497 9.75773   1.000 52.55105  ? 194 ALA A HB1  1 
ATOM   2925 H HB2  . ALA A 1 194 ? -21.45650 -17.27642 8.45484   1.000 52.55105  ? 194 ALA A HB2  1 
ATOM   2926 H HB3  . ALA A 1 194 ? -21.12815 -15.74121 8.69732   1.000 52.55105  ? 194 ALA A HB3  1 
ATOM   2927 N N    . GLY A 1 195 ? -23.78968 -13.73273 8.42191   1.000 38.60521  ? 195 GLY A N    1 
ATOM   2928 C CA   . GLY A 1 195 ? -24.42075 -12.68105 9.18616   1.000 41.21362  ? 195 GLY A CA   1 
ATOM   2929 C C    . GLY A 1 195 ? -23.62163 -12.27249 10.41646  1.000 47.04693  ? 195 GLY A C    1 
ATOM   2930 O O    . GLY A 1 195 ? -22.61271 -12.87487 10.80644  1.000 37.60588  ? 195 GLY A O    1 
ATOM   2931 H H    . GLY A 1 195 ? -23.40509 -13.47294 7.69789   1.000 46.38035  ? 195 GLY A H    1 
ATOM   2932 H HA2  . GLY A 1 195 ? -24.52871 -11.89916 8.62235   1.000 49.51045  ? 195 GLY A HA2  1 
ATOM   2933 H HA3  . GLY A 1 195 ? -25.29496 -12.98193 9.47962   1.000 49.51045  ? 195 GLY A HA3  1 
ATOM   2934 N N    . THR A 1 196 ? -24.11959 -11.23009 11.06181  1.000 38.16790  ? 196 THR A N    1 
ATOM   2935 C CA   . THR A 1 196 ? -23.38656 -10.55354 12.11191  1.000 43.38604  ? 196 THR A CA   1 
ATOM   2936 C C    . THR A 1 196 ? -22.92181 -11.51385 13.19461  1.000 33.18398  ? 196 THR A C    1 
ATOM   2937 O O    . THR A 1 196 ? -23.67398 -12.37615 13.64522  1.000 37.50556  ? 196 THR A O    1 
ATOM   2938 C CB   . THR A 1 196 ? -24.29221 -9.46555  12.70287  1.000 46.22792  ? 196 THR A CB   1 
ATOM   2939 O OG1  . THR A 1 196 ? -24.79734 -8.66033  11.62397  1.000 41.22307  ? 196 THR A OG1  1 
ATOM   2940 C CG2  . THR A 1 196 ? -23.51720 -8.63638  13.68633  1.000 49.11195  ? 196 THR A CG2  1 
ATOM   2941 H H    . THR A 1 196 ? -24.89405 -10.88986 10.90673  1.000 45.85558  ? 196 THR A H    1 
ATOM   2942 H HA   . THR A 1 196 ? -22.58447 -10.14882 11.74620  1.000 52.11735  ? 196 THR A HA   1 
ATOM   2943 H HB   . THR A 1 196 ? -25.04258 -9.85067  13.18196  1.000 55.52761  ? 196 THR A HB   1 
ATOM   2944 H HG1  . THR A 1 196 ? -24.19412 -8.53347  11.05333  1.000 49.52178  ? 196 THR A HG1  1 
ATOM   2945 H HG21 . THR A 1 196 ? -24.03517 -7.85809  13.94494  1.000 58.98844  ? 196 THR A HG21 1 
ATOM   2946 H HG22 . THR A 1 196 ? -23.31914 -9.16009  14.47841  1.000 58.98844  ? 196 THR A HG22 1 
ATOM   2947 H HG23 . THR A 1 196 ? -22.68367 -8.34143  13.28741  1.000 58.98844  ? 196 THR A HG23 1 
ATOM   2948 N N    . ASP A 1 197 ? -21.67339 -11.32009 13.62862  1.000 35.04589  ? 197 ASP A N    1 
ATOM   2949 C CA   . ASP A 1 197 ? -20.94869 -12.20881 14.55510  1.000 40.81631  ? 197 ASP A CA   1 
ATOM   2950 C C    . ASP A 1 197 ? -20.93188 -11.60148 15.95793  1.000 47.37243  ? 197 ASP A C    1 
ATOM   2951 O O    . ASP A 1 197 ? -19.97421 -10.94179 16.36184  1.000 49.30475  ? 197 ASP A O    1 
ATOM   2952 C CB   . ASP A 1 197 ? -19.53443 -12.41608 14.01461  1.000 45.44524  ? 197 ASP A CB   1 
ATOM   2953 C CG   . ASP A 1 197 ? -18.72540 -13.46076 14.78632  1.000 46.91607  ? 197 ASP A CG   1 
ATOM   2954 O OD1  . ASP A 1 197 ? -19.26772 -14.13408 15.69799  1.000 36.12486  ? 197 ASP A OD1  1 
ATOM   2955 O OD2  . ASP A 1 197 ? -17.52443 -13.59691 14.46053  1.000 52.33007  ? 197 ASP A OD2  1 
ATOM   2956 H H    . ASP A 1 197 ? -21.19625 -10.64558 13.38993  1.000 42.10917  ? 197 ASP A H    1 
ATOM   2957 H HA   . ASP A 1 197 ? -21.42018 -13.05326 14.62934  1.000 49.03368  ? 197 ASP A HA   1 
ATOM   2958 H HB2  . ASP A 1 197 ? -19.59287 -12.71001 13.09206  1.000 54.58839  ? 197 ASP A HB2  1 
ATOM   2959 H HB3  . ASP A 1 197 ? -19.05466 -11.57454 14.06492  1.000 54.58839  ? 197 ASP A HB3  1 
ATOM   2960 N N    . THR A 1 198 ? -21.97428 -11.88438 16.73576  1.000 34.21559  ? 198 THR A N    1 
ATOM   2961 C CA   . THR A 1 198 ? -22.11579 -11.28871 18.05705  1.000 35.55962  ? 198 THR A CA   1 
ATOM   2962 C C    . THR A 1 198 ? -21.28047 -11.99037 19.13100  1.000 39.82507  ? 198 THR A C    1 
ATOM   2963 O O    . THR A 1 198 ? -20.90609 -13.16547 19.02759  1.000 37.93555  ? 198 THR A O    1 
ATOM   2964 C CB   . THR A 1 198 ? -23.58815 -11.30111 18.45516  1.000 49.69958  ? 198 THR A CB   1 
ATOM   2965 O OG1  . THR A 1 198 ? -24.01845 -12.65702 18.58908  1.000 49.13199  ? 198 THR A OG1  1 
ATOM   2966 C CG2  . THR A 1 198 ? -24.43663 -10.61737 17.38145  1.000 53.79288  ? 198 THR A CG2  1 
ATOM   2967 H H    . THR A 1 198 ? -22.61254 -12.41872 16.51964  1.000 41.11280  ? 198 THR A H    1 
ATOM   2968 H HA   . THR A 1 198 ? -21.78634 -10.37716 18.01890  1.000 42.72564  ? 198 THR A HA   1 
ATOM   2969 H HB   . THR A 1 198 ? -23.70768 -10.82639 19.29257  1.000 59.69360  ? 198 THR A HB   1 
ATOM   2970 H HG1  . THR A 1 198 ? -24.78788 -12.68240 18.92513  1.000 59.01249  ? 198 THR A HG1  1 
ATOM   2971 H HG21 . THR A 1 198 ? -24.85829 -11.28431 16.81728  1.000 64.60555  ? 198 THR A HG21 1 
ATOM   2972 H HG22 . THR A 1 198 ? -25.12557 -10.07618 17.79783  1.000 64.60555  ? 198 THR A HG22 1 
ATOM   2973 H HG23 . THR A 1 198 ? -23.87805 -10.04679 16.83071  1.000 64.60555  ? 198 THR A HG23 1 
ATOM   2974 N N    . THR A 1 199 ? -20.99250 -11.24737 20.18303  1.000 30.42199  ? 199 THR A N    1 
ATOM   2975 C CA   . THR A 1 199 ? -20.12464 -11.73643 21.25727  1.000 35.42396  ? 199 THR A CA   1 
ATOM   2976 C C    . THR A 1 199 ? -20.91340 -12.45599 22.34401  1.000 37.50136  ? 199 THR A C    1 
ATOM   2977 O O    . THR A 1 199 ? -22.00085 -12.03268 22.74720  1.000 34.16693  ? 199 THR A O    1 
ATOM   2978 C CB   . THR A 1 199 ? -19.32827 -10.57588 21.84486  1.000 36.21217  ? 199 THR A CB   1 
ATOM   2979 O OG1  . THR A 1 199 ? -18.61910 -9.93652  20.78548  1.000 33.64460  ? 199 THR A OG1  1 
ATOM   2980 C CG2  . THR A 1 199 ? -18.31559 -11.06056 22.83305  1.000 30.94532  ? 199 THR A CG2  1 
ATOM   2981 H H    . THR A 1 199 ? -21.28607 -10.44849 20.30636  1.000 36.56049  ? 199 THR A H    1 
ATOM   2982 H HA   . THR A 1 199 ? -19.50622 -12.38942 20.89388  1.000 42.56285  ? 199 THR A HA   1 
ATOM   2983 H HB   . THR A 1 199 ? -19.93523 -9.96533  22.29178  1.000 43.50871  ? 199 THR A HB   1 
ATOM   2984 H HG1  . THR A 1 199 ? -18.75215 -10.34454 20.06339  1.000 40.42762  ? 199 THR A HG1  1 
ATOM   2985 H HG21 . THR A 1 199 ? -17.76406 -10.32101 23.13271  1.000 37.18848  ? 199 THR A HG21 1 
ATOM   2986 H HG22 . THR A 1 199 ? -18.76166 -11.45173 23.60046  1.000 37.18848  ? 199 THR A HG22 1 
ATOM   2987 H HG23 . THR A 1 199 ? -17.74715 -11.73146 22.42359  1.000 37.18848  ? 199 THR A HG23 1 
ATOM   2988 N N    . ILE A 1 200 ? -20.34175 -13.56786 22.81259  1.000 32.36687  ? 200 ILE A N    1 
ATOM   2989 C CA   . ILE A 1 200 ? -20.94809 -14.41044 23.82308  1.000 28.65700  ? 200 ILE A CA   1 
ATOM   2990 C C    . ILE A 1 200 ? -20.73680 -13.82749 25.21314  1.000 31.37649  ? 200 ILE A C    1 
ATOM   2991 O O    . ILE A 1 200 ? -19.76173 -14.16597 25.90244  1.000 28.50091  ? 200 ILE A O    1 
ATOM   2992 C CB   . ILE A 1 200 ? -20.36287 -15.83605 23.74775  1.000 26.35439  ? 200 ILE A CB   1 
ATOM   2993 C CG1  . ILE A 1 200 ? -20.44030 -16.39877 22.33384  1.000 31.50888  ? 200 ILE A CG1  1 
ATOM   2994 C CG2  . ILE A 1 200 ? -21.07564 -16.72164 24.72770  1.000 30.01190  ? 200 ILE A CG2  1 
ATOM   2995 C CD1  . ILE A 1 200 ? -19.35763 -17.47956 22.04739  1.000 29.32421  ? 200 ILE A CD1  1 
ATOM   2996 H H    . ILE A 1 200 ? -19.57708 -13.85837 22.54708  1.000 38.89435  ? 200 ILE A H    1 
ATOM   2997 H HA   . ILE A 1 200 ? -21.90452 -14.43611 23.66343  1.000 34.44250  ? 200 ILE A HA   1 
ATOM   2998 H HB   . ILE A 1 200 ? -19.42246 -15.79622 23.98216  1.000 31.67937  ? 200 ILE A HB   1 
ATOM   2999 H HG12 . ILE A 1 200 ? -21.31103 -16.80629 22.20476  1.000 37.86475  ? 200 ILE A HG12 1 
ATOM   3000 H HG13 . ILE A 1 200 ? -20.31542 -15.67516 21.70005  1.000 37.86475  ? 200 ILE A HG13 1 
ATOM   3001 H HG21 . ILE A 1 200 ? -20.70224 -17.61536 24.67530  1.000 36.06838  ? 200 ILE A HG21 1 
ATOM   3002 H HG22 . ILE A 1 200 ? -20.95517 -16.36471 25.62156  1.000 36.06838  ? 200 ILE A HG22 1 
ATOM   3003 H HG23 . ILE A 1 200 ? -22.01942 -16.74388 24.50482  1.000 36.06838  ? 200 ILE A HG23 1 
ATOM   3004 H HD11 . ILE A 1 200 ? -19.78073 -18.24889 21.63505  1.000 35.24315  ? 200 ILE A HD11 1 
ATOM   3005 H HD12 . ILE A 1 200 ? -18.69121 -17.10800 21.44845  1.000 35.24315  ? 200 ILE A HD12 1 
ATOM   3006 H HD13 . ILE A 1 200 ? -18.94190 -17.73969 22.88429  1.000 35.24315  ? 200 ILE A HD13 1 
ATOM   3007 N N    . THR A 1 201 ? -21.68994 -12.99933 25.65928  1.000 33.55455  ? 201 THR A N    1 
ATOM   3008 C CA   . THR A 1 201 ? -21.54711 -12.24460 26.90068  1.000 28.88512  ? 201 THR A CA   1 
ATOM   3009 C C    . THR A 1 201 ? -21.23694 -13.11676 28.10604  1.000 27.57886  ? 201 THR A C    1 
ATOM   3010 O O    . THR A 1 201 ? -20.31642 -12.80570 28.87595  1.000 30.05858  ? 201 THR A O    1 
ATOM   3011 C CB   . THR A 1 201 ? -22.83188 -11.44798 27.14648  1.000 33.94859  ? 201 THR A CB   1 
ATOM   3012 O OG1  . THR A 1 201 ? -23.14503 -10.75463 25.93251  1.000 29.42359  ? 201 THR A OG1  1 
ATOM   3013 C CG2  . THR A 1 201 ? -22.66073 -10.47975 28.34060  1.000 34.33956  ? 201 THR A CG2  1 
ATOM   3014 H H    . THR A 1 201 ? -22.43555 -12.85764 25.25482  1.000 40.31956  ? 201 THR A H    1 
ATOM   3015 H HA   . THR A 1 201 ? -20.79495 -11.64116 26.79571  1.000 34.71625  ? 201 THR A HA   1 
ATOM   3016 H HB   . THR A 1 201 ? -23.57247 -12.02726 27.38492  1.000 40.79241  ? 201 THR A HB   1 
ATOM   3017 H HG1  . THR A 1 201 ? -22.44380 -10.44373 25.59013  1.000 35.36241  ? 201 THR A HG1  1 
ATOM   3018 H HG21 . THR A 1 201 ? -21.93824 -9.85756  28.16232  1.000 41.26158  ? 201 THR A HG21 1 
ATOM   3019 H HG22 . THR A 1 201 ? -23.47953 -9.97924  28.48188  1.000 41.26158  ? 201 THR A HG22 1 
ATOM   3020 H HG23 . THR A 1 201 ? -22.45430 -10.97946 29.14595  1.000 41.26158  ? 201 THR A HG23 1 
ATOM   3021 N N    . VAL A 1 202 ? -21.99221 -14.20384 28.30804  1.000 27.39695  ? 202 VAL A N    1 
ATOM   3022 C CA   . VAL A 1 202 ? -21.77009 -14.99666 29.50423  1.000 30.83467  ? 202 VAL A CA   1 
ATOM   3023 C C    . VAL A 1 202 ? -20.35241 -15.55969 29.54194  1.000 31.30177  ? 202 VAL A C    1 
ATOM   3024 O O    . VAL A 1 202 ? -19.78898 -15.77159 30.62804  1.000 28.74164  ? 202 VAL A O    1 
ATOM   3025 C CB   . VAL A 1 202 ? -22.83559 -16.10470 29.62654  1.000 25.56997  ? 202 VAL A CB   1 
ATOM   3026 C CG1  . VAL A 1 202 ? -22.78820 -17.12025 28.45103  1.000 36.72252  ? 202 VAL A CG1  1 
ATOM   3027 C CG2  . VAL A 1 202 ? -22.64211 -16.83077 30.92805  1.000 31.24325  ? 202 VAL A CG2  1 
ATOM   3028 H H    . VAL A 1 202 ? -22.61312 -14.48635 27.78434  1.000 32.93044  ? 202 VAL A H    1 
ATOM   3029 H HA   . VAL A 1 202 ? -21.86663 -14.41243 30.27252  1.000 37.05570  ? 202 VAL A HA   1 
ATOM   3030 H HB   . VAL A 1 202 ? -23.70853 -15.68286 29.59609  1.000 30.73806  ? 202 VAL A HB   1 
ATOM   3031 H HG11 . VAL A 1 202 ? -22.21576 -16.76755 27.75188  1.000 44.12112  ? 202 VAL A HG11 1 
ATOM   3032 H HG12 . VAL A 1 202 ? -22.43329 -17.96264 28.77558  1.000 44.12112  ? 202 VAL A HG12 1 
ATOM   3033 H HG13 . VAL A 1 202 ? -23.68665 -17.24964 28.10907  1.000 44.12112  ? 202 VAL A HG13 1 
ATOM   3034 H HG21 . VAL A 1 202 ? -23.43122 -17.36381 31.11265  1.000 37.54600  ? 202 VAL A HG21 1 
ATOM   3035 H HG22 . VAL A 1 202 ? -21.86403 -17.40553 30.85640  1.000 37.54600  ? 202 VAL A HG22 1 
ATOM   3036 H HG23 . VAL A 1 202 ? -22.50912 -16.18069 31.63559  1.000 37.54600  ? 202 VAL A HG23 1 
ATOM   3037 N N    . ASN A 1 203 ? -19.77377 -15.85093 28.37573  1.000 31.13081  ? 203 ASN A N    1 
ATOM   3038 C CA   . ASN A 1 203 ? -18.39799 -16.35166 28.32082  1.000 25.25490  ? 203 ASN A CA   1 
ATOM   3039 C C    . ASN A 1 203 ? -17.37783 -15.24006 28.61037  1.000 30.64293  ? 203 ASN A C    1 
ATOM   3040 O O    . ASN A 1 203 ? -16.36055 -15.48557 29.25357  1.000 32.61177  ? 203 ASN A O    1 
ATOM   3041 C CB   . ASN A 1 203 ? -18.12035 -16.98171 26.95594  1.000 29.94675  ? 203 ASN A CB   1 
ATOM   3042 C CG   . ASN A 1 203 ? -18.87037 -18.29610 26.70568  1.000 34.94224  ? 203 ASN A CG   1 
ATOM   3043 O OD1  . ASN A 1 203 ? -19.68141 -18.77762 27.51692  1.000 30.05393  ? 203 ASN A OD1  1 
ATOM   3044 N ND2  . ASN A 1 203 ? -18.61310 -18.87189 25.54379  1.000 32.71964  ? 203 ASN A ND2  1 
ATOM   3045 H H    . ASN A 1 203 ? -20.15128 -15.76880 27.60739  1.000 37.41107  ? 203 ASN A H    1 
ATOM   3046 H HA   . ASN A 1 203 ? -18.29597 -17.03691 28.99974  1.000 30.35998  ? 203 ASN A HA   1 
ATOM   3047 H HB2  . ASN A 1 203 ? -18.38670 -16.35534 26.26485  1.000 35.99020  ? 203 ASN A HB2  1 
ATOM   3048 H HB3  . ASN A 1 203 ? -17.17083 -17.16763 26.88714  1.000 35.99020  ? 203 ASN A HB3  1 
ATOM   3049 H HD21 . ASN A 1 203 ? -18.99836 -19.61218 25.33608  1.000 39.31767  ? 203 ASN A HD21 1 
ATOM   3050 H HD22 . ASN A 1 203 ? -18.06047 -18.50616 24.99566  1.000 39.31767  ? 203 ASN A HD22 1 
ATOM   3051 N N    . VAL A 1 204 ? -17.61943 -14.01685 28.13629  1.000 30.45037  ? 204 VAL A N    1 
ATOM   3052 C CA   . VAL A 1 204 ? -16.71604 -12.93870 28.53914  1.000 28.01143  ? 204 VAL A CA   1 
ATOM   3053 C C    . VAL A 1 204 ? -16.68780 -12.80213 30.05520  1.000 30.59303  ? 204 VAL A C    1 
ATOM   3054 O O    . VAL A 1 204 ? -15.61495 -12.62033 30.65524  1.000 29.64792  ? 204 VAL A O    1 
ATOM   3055 C CB   . VAL A 1 204 ? -17.10886 -11.61605 27.86394  1.000 31.74986  ? 204 VAL A CB   1 
ATOM   3056 C CG1  . VAL A 1 204 ? -16.20754 -10.47154 28.32434  1.000 29.63913  ? 204 VAL A CG1  1 
ATOM   3057 C CG2  . VAL A 1 204 ? -17.02311 -11.79707 26.41622  1.000 28.15759  ? 204 VAL A CG2  1 
ATOM   3058 H H    . VAL A 1 204 ? -18.26290 -13.79679 27.60987  1.000 36.59454  ? 204 VAL A H    1 
ATOM   3059 H HA   . VAL A 1 204 ? -15.82261 -13.16992 28.24045  1.000 33.66781  ? 204 VAL A HA   1 
ATOM   3060 H HB   . VAL A 1 204 ? -18.01527 -11.37429 28.11068  1.000 38.15393  ? 204 VAL A HB   1 
ATOM   3061 H HG11 . VAL A 1 204 ? -16.49889 -9.64963  27.89952  1.000 35.62106  ? 204 VAL A HG11 1 
ATOM   3062 H HG12 . VAL A 1 204 ? -16.27251 -10.38664 29.28843  1.000 35.62106  ? 204 VAL A HG12 1 
ATOM   3063 H HG13 . VAL A 1 204 ? -15.29231 -10.66865 28.07057  1.000 35.62106  ? 204 VAL A HG13 1 
ATOM   3064 H HG21 . VAL A 1 204 ? -16.79819 -10.94804 26.00457  1.000 33.84321  ? 204 VAL A HG21 1 
ATOM   3065 H HG22 . VAL A 1 204 ? -16.33528 -12.45229 26.22008  1.000 33.84321  ? 204 VAL A HG22 1 
ATOM   3066 H HG23 . VAL A 1 204 ? -17.88028 -12.10822 26.08554  1.000 33.84321  ? 204 VAL A HG23 1 
ATOM   3067 N N    . LEU A 1 205 ? -17.86590 -12.83784 30.68850  1.000 30.31289  ? 205 LEU A N    1 
ATOM   3068 C CA   . LEU A 1 205 ? -17.94544 -12.71154 32.14159  1.000 31.01611  ? 205 LEU A CA   1 
ATOM   3069 C C    . LEU A 1 205 ? -17.26241 -13.87589 32.81265  1.000 31.30992  ? 205 LEU A C    1 
ATOM   3070 O O    . LEU A 1 205 ? -16.53127 -13.69933 33.78951  1.000 32.20982  ? 205 LEU A O    1 
ATOM   3071 C CB   . LEU A 1 205 ? -19.41589 -12.62957 32.56966  1.000 30.51561  ? 205 LEU A CB   1 
ATOM   3072 C CG   . LEU A 1 205 ? -20.17875 -11.42712 32.02073  1.000 34.14063  ? 205 LEU A CG   1 
ATOM   3073 C CD1  . LEU A 1 205 ? -21.68576 -11.55564 32.29027  1.000 35.80312  ? 205 LEU A CD1  1 
ATOM   3074 C CD2  . LEU A 1 205 ? -19.62311 -10.10179 32.60953  1.000 32.87018  ? 205 LEU A CD2  1 
ATOM   3075 H H    . LEU A 1 205 ? -18.62741 -12.93370 30.30054  1.000 36.42957  ? 205 LEU A H    1 
ATOM   3076 H HA   . LEU A 1 205 ? -17.50250 -11.89542 32.42202  1.000 37.27344  ? 205 LEU A HA   1 
ATOM   3077 H HB2  . LEU A 1 205 ? -19.87019 -13.42915 32.26114  1.000 36.67283  ? 205 LEU A HB2  1 
ATOM   3078 H HB3  . LEU A 1 205 ? -19.45124 -12.58057 33.53778  1.000 36.67283  ? 205 LEU A HB3  1 
ATOM   3079 H HG   . LEU A 1 205 ? -20.05490 -11.39968 31.05906  1.000 41.02286  ? 205 LEU A HG   1 
ATOM   3080 H HD11 . LEU A 1 205 ? -22.16185 -10.92275 31.73019  1.000 43.01784  ? 205 LEU A HD11 1 
ATOM   3081 H HD12 . LEU A 1 205 ? -21.96797 -12.45984 32.08128  1.000 43.01784  ? 205 LEU A HD12 1 
ATOM   3082 H HD13 . LEU A 1 205 ? -21.85680 -11.36359 33.22556  1.000 43.01784  ? 205 LEU A HD13 1 
ATOM   3083 H HD21 . LEU A 1 205 ? -20.25466 -9.38757  32.43083  1.000 39.49831  ? 205 LEU A HD21 1 
ATOM   3084 H HD22 . LEU A 1 205 ? -19.50443 -10.20664 33.56651  1.000 39.49831  ? 205 LEU A HD22 1 
ATOM   3085 H HD23 . LEU A 1 205 ? -18.77129 -9.90266  32.19042  1.000 39.49831  ? 205 LEU A HD23 1 
ATOM   3086 N N    . ALA A 1 206 ? -17.41294 -15.08456 32.25609  1.000 27.60873  ? 206 ALA A N    1 
ATOM   3087 C CA   . ALA A 1 206 ? -16.74764 -16.22275 32.85830  1.000 33.53999  ? 206 ALA A CA   1 
ATOM   3088 C C    . ALA A 1 206 ? -15.23986 -16.00650 32.85808  1.000 33.31273  ? 206 ALA A C    1 
ATOM   3089 O O    . ALA A 1 206 ? -14.54995 -16.34752 33.83407  1.000 34.68469  ? 206 ALA A O    1 
ATOM   3090 C CB   . ALA A 1 206 ? -17.15068 -17.49449 32.11671  1.000 30.37078  ? 206 ALA A CB   1 
ATOM   3091 H H    . ALA A 1 206 ? -17.87993 -15.25719 31.55486  1.000 33.18458  ? 206 ALA A H    1 
ATOM   3092 H HA   . ALA A 1 206 ? -17.02503 -16.33386 33.78113  1.000 40.30209  ? 206 ALA A HA   1 
ATOM   3093 H HB1  . ALA A 1 206 ? -18.09430 -17.66187 32.26661  1.000 36.49904  ? 206 ALA A HB1  1 
ATOM   3094 H HB2  . ALA A 1 206 ? -16.98255 -17.37416 31.16900  1.000 36.49904  ? 206 ALA A HB2  1 
ATOM   3095 H HB3  . ALA A 1 206 ? -16.62537 -18.23681 32.45422  1.000 36.49904  ? 206 ALA A HB3  1 
ATOM   3096 N N    . TRP A 1 207 ? -14.72243 -15.47171 31.75262  1.000 27.83887  ? 207 TRP A N    1 
ATOM   3097 C CA   . TRP A 1 207 ? -13.28629 -15.25129 31.58198  1.000 29.82837  ? 207 TRP A CA   1 
ATOM   3098 C C    . TRP A 1 207 ? -12.78612 -14.10459 32.45151  1.000 34.58469  ? 207 TRP A C    1 
ATOM   3099 O O    . TRP A 1 207 ? -11.69589 -14.18854 33.02414  1.000 34.12164  ? 207 TRP A O    1 
ATOM   3100 C CB   . TRP A 1 207 ? -13.01821 -15.01260 30.09314  1.000 29.21096  ? 207 TRP A CB   1 
ATOM   3101 C CG   . TRP A 1 207 ? -11.63186 -14.54150 29.67393  1.000 30.72148  ? 207 TRP A CG   1 
ATOM   3102 C CD1  . TRP A 1 207 ? -10.49765 -15.31333 29.45497  1.000 32.60038  ? 207 TRP A CD1  1 
ATOM   3103 C CD2  . TRP A 1 207 ? -11.24740 -13.19484 29.35684  1.000 29.89006  ? 207 TRP A CD2  1 
ATOM   3104 N NE1  . TRP A 1 207 ? -9.45996  -14.52180 29.03999  1.000 34.28029  ? 207 TRP A NE1  1 
ATOM   3105 C CE2  . TRP A 1 207 ? -9.89056  -13.22040 28.97084  1.000 33.89498  ? 207 TRP A CE2  1 
ATOM   3106 C CE3  . TRP A 1 207 ? -11.92299 -11.97145 29.36305  1.000 35.33843  ? 207 TRP A CE3  1 
ATOM   3107 C CZ2  . TRP A 1 207 ? -9.20016  -12.06596 28.60900  1.000 37.57662  ? 207 TRP A CZ2  1 
ATOM   3108 C CZ3  . TRP A 1 207 ? -11.23325 -10.83203 28.99559  1.000 37.95755  ? 207 TRP A CZ3  1 
ATOM   3109 C CH2  . TRP A 1 207 ? -9.88929  -10.89643 28.60911  1.000 34.22786  ? 207 TRP A CH2  1 
ATOM   3110 H H    . TRP A 1 207 ? -15.18804 -15.22292 31.07372  1.000 33.46074  ? 207 TRP A H    1 
ATOM   3111 H HA   . TRP A 1 207 ? -12.78578 -16.03355 31.86208  1.000 35.84815  ? 207 TRP A HA   1 
ATOM   3112 H HB2  . TRP A 1 207 ? -13.17799 -15.84867 29.62800  1.000 35.10725  ? 207 TRP A HB2  1 
ATOM   3113 H HB3  . TRP A 1 207 ? -13.64359 -14.33753 29.78642  1.000 35.10725  ? 207 TRP A HB3  1 
ATOM   3114 H HD1  . TRP A 1 207 ? -10.44996 -16.23456 29.57314  1.000 39.17456  ? 207 TRP A HD1  1 
ATOM   3115 H HE1  . TRP A 1 207 ? -8.66658  -14.79593 28.85293  1.000 41.19045  ? 207 TRP A HE1  1 
ATOM   3116 H HE3  . TRP A 1 207 ? -12.81855 -11.92522 29.60950  1.000 42.46021  ? 207 TRP A HE3  1 
ATOM   3117 H HZ2  . TRP A 1 207 ? -8.30032  -12.09537 28.37594  1.000 45.14604  ? 207 TRP A HZ2  1 
ATOM   3118 H HZ3  . TRP A 1 207 ? -11.66829 -10.01011 29.00514  1.000 45.60316  ? 207 TRP A HZ3  1 
ATOM   3119 H HH2  . TRP A 1 207 ? -9.45673  -10.11660 28.34521  1.000 41.12753  ? 207 TRP A HH2  1 
ATOM   3120 N N    . LEU A 1 208 ? -13.59124 -13.05765 32.62059  1.000 32.88773  ? 208 LEU A N    1 
ATOM   3121 C CA   . LEU A 1 208 ? -13.30497 -12.07552 33.66981  1.000 32.68707  ? 208 LEU A CA   1 
ATOM   3122 C C    . LEU A 1 208 ? -13.25682 -12.70230 35.06711  1.000 32.94888  ? 208 LEU A C    1 
ATOM   3123 O O    . LEU A 1 208 ? -12.37815 -12.35453 35.86376  1.000 36.10977  ? 208 LEU A O    1 
ATOM   3124 C CB   . LEU A 1 208 ? -14.33346 -10.95053 33.61583  1.000 31.99909  ? 208 LEU A CB   1 
ATOM   3125 C CG   . LEU A 1 208 ? -14.19019 -10.07829 32.37136  1.000 32.49611  ? 208 LEU A CG   1 
ATOM   3126 C CD1  . LEU A 1 208 ? -15.26606 -8.99749  32.31185  1.000 33.82527  ? 208 LEU A CD1  1 
ATOM   3127 C CD2  . LEU A 1 208 ? -12.81488 -9.43362  32.25939  1.000 34.06503  ? 208 LEU A CD2  1 
ATOM   3128 H H    . LEU A 1 208 ? -14.29451 -12.89371 32.15353  1.000 39.51937  ? 208 LEU A H    1 
ATOM   3129 H HA   . LEU A 1 208 ? -12.42636 -11.70066 33.50121  1.000 39.27859  ? 208 LEU A HA   1 
ATOM   3130 H HB2  . LEU A 1 208 ? -15.22312 -11.33702 33.61167  1.000 38.45301  ? 208 LEU A HB2  1 
ATOM   3131 H HB3  . LEU A 1 208 ? -14.22159 -10.38381 34.39507  1.000 38.45301  ? 208 LEU A HB3  1 
ATOM   3132 H HG   . LEU A 1 208 ? -14.30055 -10.67073 31.61127  1.000 39.04943  ? 208 LEU A HG   1 
ATOM   3133 H HD11 . LEU A 1 208 ? -16.09811 -9.36102  32.65311  1.000 40.64443  ? 208 LEU A HD11 1 
ATOM   3134 H HD12 . LEU A 1 208 ? -14.98696 -8.24383  32.85498  1.000 40.64443  ? 208 LEU A HD12 1 
ATOM   3135 H HD13 . LEU A 1 208 ? -15.38100 -8.71670  31.39052  1.000 40.64443  ? 208 LEU A HD13 1 
ATOM   3136 H HD21 . LEU A 1 208 ? -12.83706 -8.76166  31.56019  1.000 40.93213  ? 208 LEU A HD21 1 
ATOM   3137 H HD22 . LEU A 1 208 ? -12.58956 -9.02088  33.10779  1.000 40.93213  ? 208 LEU A HD22 1 
ATOM   3138 H HD23 . LEU A 1 208 ? -12.16250 -10.11730 32.04054  1.000 40.93213  ? 208 LEU A HD23 1 
ATOM   3139 N N    . TYR A 1 209 ? -14.18330 -13.61856 35.39639  1.000 31.59564  ? 209 TYR A N    1 
ATOM   3140 C CA   . TYR A 1 209 ? -14.06199 -14.34746 36.65542  1.000 38.05840  ? 209 TYR A CA   1 
ATOM   3141 C C    . TYR A 1 209 ? -12.77236 -15.15145 36.68614  1.000 40.39777  ? 209 TYR A C    1 
ATOM   3142 O O    . TYR A 1 209 ? -12.04102 -15.12925 37.67733  1.000 40.10633  ? 209 TYR A O    1 
ATOM   3143 C CB   . TYR A 1 209 ? -15.26117 -15.26367 36.90366  1.000 34.35122  ? 209 TYR A CB   1 
ATOM   3144 C CG   . TYR A 1 209 ? -16.44575 -14.51957 37.48137  1.000 39.79862  ? 209 TYR A CG   1 
ATOM   3145 C CD1  . TYR A 1 209 ? -16.46835 -14.15032 38.83113  1.000 43.88515  ? 209 TYR A CD1  1 
ATOM   3146 C CD2  . TYR A 1 209 ? -17.51717 -14.15253 36.69241  1.000 37.02956  ? 209 TYR A CD2  1 
ATOM   3147 C CE1  . TYR A 1 209 ? -17.52883 -13.45064 39.35317  1.000 43.21637  ? 209 TYR A CE1  1 
ATOM   3148 C CE2  . TYR A 1 209 ? -18.59581 -13.45010 37.22427  1.000 41.34663  ? 209 TYR A CE2  1 
ATOM   3149 C CZ   . TYR A 1 209 ? -18.58390 -13.09443 38.54863  1.000 45.48311  ? 209 TYR A CZ   1 
ATOM   3150 O OH   . TYR A 1 209 ? -19.64017 -12.38609 39.07721  1.000 40.27411  ? 209 TYR A OH   1 
ATOM   3151 H H    . TYR A 1 209 ? -14.86805 -13.82604 34.91923  1.000 37.96887  ? 209 TYR A H    1 
ATOM   3152 H HA   . TYR A 1 209 ? -14.05359 -13.69690 37.37486  1.000 45.72418  ? 209 TYR A HA   1 
ATOM   3153 H HB2  . TYR A 1 209 ? -15.53562 -15.66160 36.06269  1.000 41.27556  ? 209 TYR A HB2  1 
ATOM   3154 H HB3  . TYR A 1 209 ? -15.00541 -15.95767 37.53124  1.000 41.27556  ? 209 TYR A HB3  1 
ATOM   3155 H HD1  . TYR A 1 209 ? -15.75574 -14.38180 39.38203  1.000 52.71628  ? 209 TYR A HD1  1 
ATOM   3156 H HD2  . TYR A 1 209 ? -17.51885 -14.37814 35.79019  1.000 44.48957  ? 209 TYR A HD2  1 
ATOM   3157 H HE1  . TYR A 1 209 ? -17.53262 -13.21749 40.25346  1.000 51.91374  ? 209 TYR A HE1  1 
ATOM   3158 H HE2  . TYR A 1 209 ? -19.31901 -13.22388 36.68510  1.000 49.67006  ? 209 TYR A HE2  1 
ATOM   3159 H HH   . TYR A 1 209 ? -19.66123 -12.48147 39.91151  1.000 48.38303  ? 209 TYR A HH   1 
ATOM   3160 N N    . ALA A 1 210 ? -12.44680 -15.83916 35.58378  1.000 38.49985  ? 210 ALA A N    1 
ATOM   3161 C CA   . ALA A 1 210 ? -11.19700 -16.58992 35.55321  1.000 32.13741  ? 210 ALA A CA   1 
ATOM   3162 C C    . ALA A 1 210 ? -10.01827 -15.66260 35.78827  1.000 34.18397  ? 210 ALA A C    1 
ATOM   3163 O O    . ALA A 1 210 ? -9.02369  -16.05174 36.41587  1.000 40.52878  ? 210 ALA A O    1 
ATOM   3164 C CB   . ALA A 1 210 ? -11.03791 -17.31797 34.21009  1.000 34.68124  ? 210 ALA A CB   1 
ATOM   3165 H H    . ALA A 1 210 ? -12.91926 -15.88310 34.86653  1.000 46.25393  ? 210 ALA A H    1 
ATOM   3166 H HA   . ALA A 1 210 ? -11.21661 -17.26199 36.25237  1.000 38.61900  ? 210 ALA A HA   1 
ATOM   3167 H HB1  . ALA A 1 210 ? -10.30330 -17.94783 34.27737  1.000 41.67159  ? 210 ALA A HB1  1 
ATOM   3168 H HB2  . ALA A 1 210 ? -11.86074 -17.78990 34.00728  1.000 41.67159  ? 210 ALA A HB2  1 
ATOM   3169 H HB3  . ALA A 1 210 ? -10.85155 -16.66524 33.51719  1.000 41.67159  ? 210 ALA A HB3  1 
ATOM   3170 N N    . ALA A 1 211 ? -10.09755 -14.42625 35.26957  1.000 37.60510  ? 211 ALA A N    1 
ATOM   3171 C CA   . ALA A 1 211 ? -9.01082  -13.47188 35.41763  1.000 38.32066  ? 211 ALA A CA   1 
ATOM   3172 C C    . ALA A 1 211 ? -8.84608  -13.10198 36.88058  1.000 43.29362  ? 211 ALA A C    1 
ATOM   3173 O O    . ALA A 1 211 ? -7.73266  -13.08902 37.41067  1.000 46.00904  ? 211 ALA A O    1 
ATOM   3174 C CB   . ALA A 1 211 ? -9.29146  -12.22115 34.58875  1.000 36.47234  ? 211 ALA A CB   1 
ATOM   3175 H H    . ALA A 1 211 ? -10.77202 -14.12407 34.82981  1.000 45.18022  ? 211 ALA A H    1 
ATOM   3176 H HA   . ALA A 1 211 ? -8.18795  -13.86829 35.09106  1.000 46.03890  ? 211 ALA A HA   1 
ATOM   3177 H HB1  . ALA A 1 211 ? -9.93033  -11.66545 35.06198  1.000 43.82091  ? 211 ALA A HB1  1 
ATOM   3178 H HB2  . ALA A 1 211 ? -8.46200  -11.73509 34.45977  1.000 43.82091  ? 211 ALA A HB2  1 
ATOM   3179 H HB3  . ALA A 1 211 ? -9.65623  -12.48664 33.73005  1.000 43.82091  ? 211 ALA A HB3  1 
ATOM   3180 N N    . VAL A 1 212 ? -9.96594  -12.82436 37.55363  1.000 43.00253  ? 212 VAL A N    1 
ATOM   3181 C CA   . VAL A 1 212 ? -9.91098  -12.50214 38.97833  1.000 48.98280  ? 212 VAL A CA   1 
ATOM   3182 C C    . VAL A 1 212 ? -9.33262  -13.67364 39.75943  1.000 42.95026  ? 212 VAL A C    1 
ATOM   3183 O O    . VAL A 1 212 ? -8.45857  -13.50172 40.61441  1.000 53.38333  ? 212 VAL A O    1 
ATOM   3184 C CB   . VAL A 1 212 ? -11.30576 -12.11236 39.49940  1.000 48.96101  ? 212 VAL A CB   1 
ATOM   3185 C CG1  . VAL A 1 212 ? -11.30036 -12.03439 41.02416  1.000 52.98698  ? 212 VAL A CG1  1 
ATOM   3186 C CG2  . VAL A 1 212 ? -11.73218 -10.79767 38.88418  1.000 46.29179  ? 212 VAL A CG2  1 
ATOM   3187 H H    . VAL A 1 212 ? -10.75585 -12.81623 37.21369  1.000 51.65714  ? 212 VAL A H    1 
ATOM   3188 H HA   . VAL A 1 212 ? -9.32434  -11.73908 39.09868  1.000 58.83346  ? 212 VAL A HA   1 
ATOM   3189 H HB   . VAL A 1 212 ? -11.95141 -12.78958 39.24365  1.000 58.80731  ? 212 VAL A HB   1 
ATOM   3190 H HG11 . VAL A 1 212 ? -12.14004 -11.65222 41.32381  1.000 63.63848  ? 212 VAL A HG11 1 
ATOM   3191 H HG12 . VAL A 1 212 ? -11.19613 -12.92843 41.38572  1.000 63.63848  ? 212 VAL A HG12 1 
ATOM   3192 H HG13 . VAL A 1 212 ? -10.56157 -11.47414 41.30911  1.000 63.63848  ? 212 VAL A HG13 1 
ATOM   3193 H HG21 . VAL A 1 212 ? -10.98977 -10.42934 38.38014  1.000 55.60425  ? 212 VAL A HG21 1 
ATOM   3194 H HG22 . VAL A 1 212 ? -12.48652 -10.95469 38.29492  1.000 55.60425  ? 212 VAL A HG22 1 
ATOM   3195 H HG23 . VAL A 1 212 ? -11.98729 -10.18569 39.59220  1.000 55.60425  ? 212 VAL A HG23 1 
ATOM   3196 N N    . ILE A 1 213 ? -9.82704  -14.88392 39.48864  1.000 49.78618  ? 213 ILE A N    1 
ATOM   3197 C CA   . ILE A 1 213 ? -9.32406  -16.07644 40.17078  1.000 43.97074  ? 213 ILE A CA   1 
ATOM   3198 C C    . ILE A 1 213 ? -7.81289  -16.17422 40.04147  1.000 49.09642  ? 213 ILE A C    1 
ATOM   3199 O O    . ILE A 1 213 ? -7.13344  -16.64541 40.96506  1.000 49.09111  ? 213 ILE A O    1 
ATOM   3200 C CB   . ILE A 1 213 ? -10.04306 -17.33161 39.61989  1.000 40.66796  ? 213 ILE A CB   1 
ATOM   3201 C CG1  . ILE A 1 213 ? -11.50780 -17.31147 40.08872  1.000 45.14668  ? 213 ILE A CG1  1 
ATOM   3202 C CG2  . ILE A 1 213 ? -9.33558  -18.59729 40.02927  1.000 46.04653  ? 213 ILE A CG2  1 
ATOM   3203 C CD1  . ILE A 1 213 ? -12.41285 -18.37007 39.45172  1.000 55.71644  ? 213 ILE A CD1  1 
ATOM   3204 H H    . ILE A 1 213 ? -10.45051 -15.04065 38.91740  1.000 59.79751  ? 213 ILE A H    1 
ATOM   3205 H HA   . ILE A 1 213 ? -9.52595  -16.01281 41.11741  1.000 52.81899  ? 213 ILE A HA   1 
ATOM   3206 H HB   . ILE A 1 213 ? -10.02350 -17.31180 38.65029  1.000 48.85565  ? 213 ILE A HB   1 
ATOM   3207 H HG12 . ILE A 1 213 ? -11.52411 -17.45573 41.04780  1.000 54.23012  ? 213 ILE A HG12 1 
ATOM   3208 H HG13 . ILE A 1 213 ? -11.88481 -16.44308 39.87740  1.000 54.23012  ? 213 ILE A HG13 1 
ATOM   3209 H HG21 . ILE A 1 213 ? -9.93125  -19.35049 39.89231  1.000 55.30994  ? 213 ILE A HG21 1 
ATOM   3210 H HG22 . ILE A 1 213 ? -8.53843  -18.70309 39.48681  1.000 55.30994  ? 213 ILE A HG22 1 
ATOM   3211 H HG23 . ILE A 1 213 ? -9.09218  -18.53415 40.96611  1.000 55.30994  ? 213 ILE A HG23 1 
ATOM   3212 H HD11 . ILE A 1 213 ? -13.27371 -18.35987 39.89862  1.000 66.91383  ? 213 ILE A HD11 1 
ATOM   3213 H HD12 . ILE A 1 213 ? -12.52620 -18.16379 38.51071  1.000 66.91383  ? 213 ILE A HD12 1 
ATOM   3214 H HD13 . ILE A 1 213 ? -11.99851 -19.24139 39.55177  1.000 66.91383  ? 213 ILE A HD13 1 
ATOM   3215 N N    . ASN A 1 214 ? -7.25547  -15.69152 38.92577  1.000 46.00225  ? 214 ASN A N    1 
ATOM   3216 C CA   . ASN A 1 214 ? -5.83795  -15.85956 38.62268  1.000 44.25172  ? 214 ASN A CA   1 
ATOM   3217 C C    . ASN A 1 214 ? -5.02775  -14.59461 38.89557  1.000 48.44404  ? 214 ASN A C    1 
ATOM   3218 O O    . ASN A 1 214 ? -3.89431  -14.47573 38.42067  1.000 49.23400  ? 214 ASN A O    1 
ATOM   3219 C CB   . ASN A 1 214 ? -5.68516  -16.34950 37.17447  1.000 48.36817  ? 214 ASN A CB   1 
ATOM   3220 C CG   . ASN A 1 214 ? -6.00215  -17.82924 37.03819  1.000 41.29129  ? 214 ASN A CG   1 
ATOM   3221 O OD1  . ASN A 1 214 ? -5.14439  -18.67820 37.30903  1.000 50.53817  ? 214 ASN A OD1  1 
ATOM   3222 N ND2  . ASN A 1 214 ? -7.24528  -18.16356 36.65981  1.000 39.93734  ? 214 ASN A ND2  1 
ATOM   3223 H H    . ASN A 1 214 ? -7.68813  -15.25716 38.32266  1.000 55.25680  ? 214 ASN A H    1 
ATOM   3224 H HA   . ASN A 1 214 ? -5.45961  -16.54357 39.19705  1.000 53.15617  ? 214 ASN A HA   1 
ATOM   3225 H HB2  . ASN A 1 214 ? -6.29465  -15.85509 36.60439  1.000 58.09591  ? 214 ASN A HB2  1 
ATOM   3226 H HB3  . ASN A 1 214 ? -4.77053  -16.20737 36.88437  1.000 58.09591  ? 214 ASN A HB3  1 
ATOM   3227 H HD21 . ASN A 1 214 ? -7.46009  -18.99171 36.57245  1.000 47.97891  ? 214 ASN A HD21 1 
ATOM   3228 H HD22 . ASN A 1 214 ? -7.82726  -17.54970 36.50465  1.000 47.97891  ? 214 ASN A HD22 1 
ATOM   3229 N N    . GLY A 1 215 ? -5.57890  -13.66070 39.68166  1.000 51.00852  ? 215 GLY A N    1 
ATOM   3230 C CA   . GLY A 1 215 ? -4.84410  -12.50908 40.16158  1.000 47.75531  ? 215 GLY A CA   1 
ATOM   3231 C C    . GLY A 1 215 ? -4.97203  -11.24117 39.34147  1.000 53.42658  ? 215 GLY A C    1 
ATOM   3232 O O    . GLY A 1 215 ? -4.46116  -10.19568 39.77011  1.000 58.54746  ? 215 GLY A O    1 
ATOM   3233 H H    . GLY A 1 215 ? -6.39548  -13.68197 39.95065  1.000 61.26432  ? 215 GLY A H    1 
ATOM   3234 H HA2  . GLY A 1 215 ? -5.14942  -12.30519 41.05941  1.000 57.36047  ? 215 GLY A HA2  1 
ATOM   3235 H HA3  . GLY A 1 215 ? -3.90246  -12.73978 40.19300  1.000 57.36047  ? 215 GLY A HA3  1 
ATOM   3236 N N    . ASP A 1 216 ? -5.62603  -11.29424 38.17807  1.000 48.87460  ? 216 ASP A N    1 
ATOM   3237 C CA   . ASP A 1 216 ? -5.83015  -10.13326 37.32109  1.000 49.21698  ? 216 ASP A CA   1 
ATOM   3238 C C    . ASP A 1 216 ? -7.10335  -9.41908  37.77951  1.000 54.95739  ? 216 ASP A C    1 
ATOM   3239 O O    . ASP A 1 216 ? -8.21533  -9.90596  37.52876  1.000 51.51884  ? 216 ASP A O    1 
ATOM   3240 C CB   . ASP A 1 216 ? -5.94897  -10.56647 35.85832  1.000 46.21355  ? 216 ASP A CB   1 
ATOM   3241 C CG   . ASP A 1 216 ? -4.72647  -10.23046 35.03836  1.000 57.13785  ? 216 ASP A CG   1 
ATOM   3242 O OD1  . ASP A 1 216 ? -3.98349  -9.29552  35.41548  1.000 64.97663  ? 216 ASP A OD1  1 
ATOM   3243 O OD2  . ASP A 1 216 ? -4.52265  -10.89957 33.99762  1.000 52.65817  ? 216 ASP A OD2  1 
ATOM   3244 H H    . ASP A 1 216 ? -5.96942  -12.01469 37.85769  1.000 58.70362  ? 216 ASP A H    1 
ATOM   3245 H HA   . ASP A 1 216 ? -5.07859  -9.52585  37.40552  1.000 59.11447  ? 216 ASP A HA   1 
ATOM   3246 H HB2  . ASP A 1 216 ? -6.07605  -11.52750 35.82421  1.000 55.51036  ? 216 ASP A HB2  1 
ATOM   3247 H HB3  . ASP A 1 216 ? -6.70948  -10.11683 35.45788  1.000 55.51036  ? 216 ASP A HB3  1 
ATOM   3248 N N    . ARG A 1 217 ? -6.94997  -8.27930  38.45813  1.000 52.86503  ? 217 ARG A N    1 
ATOM   3249 C CA   . ARG A 1 217 ? -8.10114  -7.63452  39.08824  1.000 54.52041  ? 217 ARG A CA   1 
ATOM   3250 C C    . ARG A 1 217 ? -8.21520  -6.13663  38.81705  1.000 51.22877  ? 217 ARG A C    1 
ATOM   3251 O O    . ARG A 1 217 ? -9.16774  -5.51139  39.30483  1.000 51.06355  ? 217 ARG A O    1 
ATOM   3252 C CB   . ARG A 1 217 ? -8.07283  -7.87616  40.61143  1.000 42.71881  ? 217 ARG A CB   1 
ATOM   3253 H H    . ARG A 1 217 ? -6.20211  -7.86835  38.56505  1.000 63.49214  ? 217 ARG A H    1 
ATOM   3254 H HA   . ARG A 1 217 ? -8.90522  -8.04208  38.73012  1.000 65.47860  ? 217 ARG A HA   1 
ATOM   3255 N N    . TRP A 1 218 ? -7.31130  -5.56009  38.01283  1.000 51.01383  ? 218 TRP A N    1 
ATOM   3256 C CA   . TRP A 1 218 ? -7.25076  -4.11056  37.83679  1.000 45.37693  ? 218 TRP A CA   1 
ATOM   3257 C C    . TRP A 1 218 ? -8.52908  -3.52970  37.24298  1.000 52.05994  ? 218 TRP A C    1 
ATOM   3258 O O    . TRP A 1 218 ? -8.81019  -2.33271  37.42825  1.000 50.21548  ? 218 TRP A O    1 
ATOM   3259 C CB   . TRP A 1 218 ? -6.06796  -3.72838  36.92966  1.000 48.11767  ? 218 TRP A CB   1 
ATOM   3260 C CG   . TRP A 1 218 ? -6.14525  -4.28606  35.50598  1.000 48.93260  ? 218 TRP A CG   1 
ATOM   3261 C CD1  . TRP A 1 218 ? -5.55990  -5.43935  35.04520  1.000 50.97354  ? 218 TRP A CD1  1 
ATOM   3262 C CD2  . TRP A 1 218 ? -6.84252  -3.71895  34.38609  1.000 50.76036  ? 218 TRP A CD2  1 
ATOM   3263 N NE1  . TRP A 1 218 ? -5.84273  -5.61604  33.70715  1.000 47.02177  ? 218 TRP A NE1  1 
ATOM   3264 C CE2  . TRP A 1 218 ? -6.63516  -4.58470  33.27889  1.000 44.60271  ? 218 TRP A CE2  1 
ATOM   3265 C CE3  . TRP A 1 218 ? -7.62678  -2.57359  34.20856  1.000 44.90335  ? 218 TRP A CE3  1 
ATOM   3266 C CZ2  . TRP A 1 218 ? -7.17962  -4.33041  32.01907  1.000 43.34498  ? 218 TRP A CZ2  1 
ATOM   3267 C CZ3  . TRP A 1 218 ? -8.16339  -2.31752  32.95821  1.000 43.22090  ? 218 TRP A CZ3  1 
ATOM   3268 C CH2  . TRP A 1 218 ? -7.93901  -3.19905  31.87390  1.000 50.34936  ? 218 TRP A CH2  1 
ATOM   3269 H H    . TRP A 1 218 ? -6.72144  -5.98977  37.55781  1.000 61.27069  ? 218 TRP A H    1 
ATOM   3270 H HA   . TRP A 1 218 ? -7.12052  -3.72368  38.71671  1.000 54.50642  ? 218 TRP A HA   1 
ATOM   3271 H HB2  . TRP A 1 218 ? -6.03114  -2.76141  36.86253  1.000 57.79531  ? 218 TRP A HB2  1 
ATOM   3272 H HB3  . TRP A 1 218 ? -5.25113  -4.06445  37.33060  1.000 57.79531  ? 218 TRP A HB3  1 
ATOM   3273 H HD1  . TRP A 1 218 ? -5.04650  -6.01815  35.56125  1.000 61.22235  ? 218 TRP A HD1  1 
ATOM   3274 H HE1  . TRP A 1 218 ? -5.56606  -6.26868  33.22020  1.000 56.48022  ? 218 TRP A HE1  1 
ATOM   3275 H HE3  . TRP A 1 218 ? -7.78487  -1.99414  34.91858  1.000 53.93812  ? 218 TRP A HE3  1 
ATOM   3276 H HZ2  . TRP A 1 218 ? -7.03247  -4.90741  31.30470  1.000 52.06808  ? 218 TRP A HZ2  1 
ATOM   3277 H HZ3  . TRP A 1 218 ? -8.67919  -1.55456  32.82884  1.000 51.91918  ? 218 TRP A HZ3  1 
ATOM   3278 H HH2  . TRP A 1 218 ? -8.31491  -3.00638  31.04536  1.000 60.47333  ? 218 TRP A HH2  1 
ATOM   3279 N N    . PHE A 1 219 ? -9.28634  -4.33084  36.48958  1.000 49.35422  ? 219 PHE A N    1 
ATOM   3280 C CA   . PHE A 1 219 ? -10.46797 -3.85869  35.77662  1.000 48.45297  ? 219 PHE A CA   1 
ATOM   3281 C C    . PHE A 1 219 ? -11.69992 -3.79249  36.66602  1.000 46.37294  ? 219 PHE A C    1 
ATOM   3282 O O    . PHE A 1 219 ? -12.76483 -3.37065  36.19751  1.000 43.04467  ? 219 PHE A O    1 
ATOM   3283 C CB   . PHE A 1 219 ? -10.76101 -4.78001  34.58533  1.000 45.32817  ? 219 PHE A CB   1 
ATOM   3284 C CG   . PHE A 1 219 ? -10.81374 -6.21841  34.96783  1.000 43.22227  ? 219 PHE A CG   1 
ATOM   3285 C CD1  . PHE A 1 219 ? -11.98570 -6.78174  35.42364  1.000 40.41200  ? 219 PHE A CD1  1 
ATOM   3286 C CD2  . PHE A 1 219 ? -9.66845  -7.00708  34.90928  1.000 44.98534  ? 219 PHE A CD2  1 
ATOM   3287 C CE1  . PHE A 1 219 ? -12.03349 -8.10097  35.80754  1.000 41.74535  ? 219 PHE A CE1  1 
ATOM   3288 C CE2  . PHE A 1 219 ? -9.71182  -8.32747  35.29188  1.000 43.82476  ? 219 PHE A CE2  1 
ATOM   3289 C CZ   . PHE A 1 219 ? -10.90562 -8.87976  35.74427  1.000 42.14249  ? 219 PHE A CZ   1 
ATOM   3290 H H    . PHE A 1 219 ? -9.13073  -5.16886  36.37506  1.000 59.27916  ? 219 PHE A H    1 
ATOM   3291 H HA   . PHE A 1 219 ? -10.28904 -2.96799  35.43670  1.000 58.19766  ? 219 PHE A HA   1 
ATOM   3292 H HB2  . PHE A 1 219 ? -11.61971 -4.53919  34.20382  1.000 54.44790  ? 219 PHE A HB2  1 
ATOM   3293 H HB3  . PHE A 1 219 ? -10.06123 -4.67113  33.92249  1.000 54.44790  ? 219 PHE A HB3  1 
ATOM   3294 H HD1  . PHE A 1 219 ? -12.75543 -6.26208  35.47227  1.000 48.54850  ? 219 PHE A HD1  1 
ATOM   3295 H HD2  . PHE A 1 219 ? -8.86876  -6.63891  34.60955  1.000 54.03651  ? 219 PHE A HD2  1 
ATOM   3296 H HE1  . PHE A 1 219 ? -12.83286 -8.46670  36.11110  1.000 50.14852  ? 219 PHE A HE1  1 
ATOM   3297 H HE2  . PHE A 1 219 ? -8.94398  -8.85035  35.24816  1.000 52.64381  ? 219 PHE A HE2  1 
ATOM   3298 H HZ   . PHE A 1 219 ? -10.93914 -9.77253  36.00260  1.000 50.62509  ? 219 PHE A HZ   1 
ATOM   3299 N N    . LEU A 1 220 ? -11.58502 -4.24773  37.90580  1.000 42.33055  ? 220 LEU A N    1 
ATOM   3300 C CA   . LEU A 1 220 ? -12.68544 -4.18586  38.85249  1.000 53.19773  ? 220 LEU A CA   1 
ATOM   3301 C C    . LEU A 1 220 ? -12.91638 -2.74358  39.28106  1.000 52.68725  ? 220 LEU A C    1 
ATOM   3302 O O    . LEU A 1 220 ? -11.97967 -1.94494  39.36746  1.000 55.75172  ? 220 LEU A O    1 
ATOM   3303 C CB   . LEU A 1 220 ? -12.37854 -5.05235  40.06734  1.000 45.23303  ? 220 LEU A CB   1 
ATOM   3304 C CG   . LEU A 1 220 ? -12.26082 -6.54844  39.76344  1.000 53.31170  ? 220 LEU A CG   1 
ATOM   3305 C CD1  . LEU A 1 220 ? -11.91880 -7.34883  41.02831  1.000 48.85547  ? 220 LEU A CD1  1 
ATOM   3306 C CD2  . LEU A 1 220 ? -13.55188 -7.06869  39.14278  1.000 56.09609  ? 220 LEU A CD2  1 
ATOM   3307 H H    . LEU A 1 220 ? -10.87042 -4.60188  38.22755  1.000 50.85076  ? 220 LEU A H    1 
ATOM   3308 H HA   . LEU A 1 220 ? -13.49927 -4.52061  38.44443  1.000 63.89138  ? 220 LEU A HA   1 
ATOM   3309 H HB2  . LEU A 1 220 ? -11.53487 -4.76233  40.44817  1.000 54.33374  ? 220 LEU A HB2  1 
ATOM   3310 H HB3  . LEU A 1 220 ? -13.09141 -4.93907  40.71533  1.000 54.33374  ? 220 LEU A HB3  1 
ATOM   3311 H HG   . LEU A 1 220 ? -11.53861 -6.67641  39.12867  1.000 64.02814  ? 220 LEU A HG   1 
ATOM   3312 H HD11 . LEU A 1 220 ? -11.92244 -8.29485  40.81401  1.000 58.68066  ? 220 LEU A HD11 1 
ATOM   3313 H HD12 . LEU A 1 220 ? -11.03979 -7.08401  41.34155  1.000 58.68066  ? 220 LEU A HD12 1 
ATOM   3314 H HD13 . LEU A 1 220 ? -12.58312 -7.16149  41.70983  1.000 58.68066  ? 220 LEU A HD13 1 
ATOM   3315 H HD21 . LEU A 1 220 ? -13.56792 -8.03611  39.21159  1.000 67.36941  ? 220 LEU A HD21 1 
ATOM   3316 H HD22 . LEU A 1 220 ? -14.30669 -6.69054  39.62046  1.000 67.36941  ? 220 LEU A HD22 1 
ATOM   3317 H HD23 . LEU A 1 220 ? -13.58361 -6.80281  38.21047  1.000 67.36941  ? 220 LEU A HD23 1 
ATOM   3318 N N    . ASN A 1 221 ? -14.17609 -2.39934  39.52605  1.000 55.38480  ? 221 ASN A N    1 
ATOM   3319 C CA   . ASN A 1 221 ? -14.49814 -1.01940  39.85538  1.000 55.44985  ? 221 ASN A CA   1 
ATOM   3320 C C    . ASN A 1 221 ? -15.54671 -0.95584  40.95411  1.000 53.44485  ? 221 ASN A C    1 
ATOM   3321 O O    . ASN A 1 221 ? -16.09016 -1.96871  41.39788  1.000 58.01327  ? 221 ASN A O    1 
ATOM   3322 C CB   . ASN A 1 221 ? -14.96709 -0.24003  38.61571  1.000 52.06440  ? 221 ASN A CB   1 
ATOM   3323 C CG   . ASN A 1 221 ? -16.30497 -0.71944  38.08429  1.000 50.99164  ? 221 ASN A CG   1 
ATOM   3324 O OD1  . ASN A 1 221 ? -17.10838 -1.33589  38.80282  1.000 49.67237  ? 221 ASN A OD1  1 
ATOM   3325 N ND2  . ASN A 1 221 ? -16.55533 -0.42992  36.80156  1.000 55.04494  ? 221 ASN A ND2  1 
ATOM   3326 H H    . ASN A 1 221 ? -14.84673 -2.93740  39.50757  1.000 66.51586  ? 221 ASN A H    1 
ATOM   3327 H HA   . ASN A 1 221 ? -13.69656 -0.60034  40.20575  1.000 66.59392  ? 221 ASN A HA   1 
ATOM   3328 H HB2  . ASN A 1 221 ? -15.05650 0.69745   38.84814  1.000 62.53138  ? 221 ASN A HB2  1 
ATOM   3329 H HB3  . ASN A 1 221 ? -14.31006 -0.34566  37.90998  1.000 62.53138  ? 221 ASN A HB3  1 
ATOM   3330 H HD21 . ASN A 1 221 ? -17.29724 -0.67508  36.44230  1.000 66.10803  ? 221 ASN A HD21 1 
ATOM   3331 H HD22 . ASN A 1 221 ? -15.97426 0.00123   36.33673  1.000 66.10803  ? 221 ASN A HD22 1 
ATOM   3332 N N    . ARG A 1 222 ? -15.81589 0.27832   41.38418  1.000 61.37337  ? 222 ARG A N    1 
ATOM   3333 C CA   . ARG A 1 222 ? -16.70237 0.58877   42.49709  1.000 60.22072  ? 222 ARG A CA   1 
ATOM   3334 C C    . ARG A 1 222 ? -18.16658 0.69113   42.08525  1.000 59.47773  ? 222 ARG A C    1 
ATOM   3335 O O    . ARG A 1 222 ? -18.99414 1.11384   42.89817  1.000 58.71714  ? 222 ARG A O    1 
ATOM   3336 C CB   . ARG A 1 222 ? -16.25897 1.91075   43.14297  1.000 58.78756  ? 222 ARG A CB   1 
ATOM   3337 H H    . ARG A 1 222 ? -15.47854 0.98428   41.02725  1.000 73.70214  ? 222 ARG A H    1 
ATOM   3338 H HA   . ARG A 1 222 ? -16.63450 -0.12078  43.15498  1.000 72.31896  ? 222 ARG A HA   1 
ATOM   3339 N N    . PHE A 1 223 ? -18.49636 0.32984   40.84534  1.000 49.23310  ? 223 PHE A N    1 
ATOM   3340 C CA   . PHE A 1 223 ? -19.81696 0.55711   40.29421  1.000 47.35851  ? 223 PHE A CA   1 
ATOM   3341 C C    . PHE A 1 223 ? -20.56430 -0.76145  40.18896  1.000 49.15259  ? 223 PHE A C    1 
ATOM   3342 O O    . PHE A 1 223 ? -19.97283 -1.84179  40.26310  1.000 39.65015  ? 223 PHE A O    1 
ATOM   3343 C CB   . PHE A 1 223 ? -19.77606 1.18479   38.89921  1.000 52.35234  ? 223 PHE A CB   1 
ATOM   3344 C CG   . PHE A 1 223 ? -18.72264 2.23789   38.72530  1.000 53.35544  ? 223 PHE A CG   1 
ATOM   3345 C CD1  . PHE A 1 223 ? -18.20884 2.93028   39.81335  1.000 59.11321  ? 223 PHE A CD1  1 
ATOM   3346 C CD2  . PHE A 1 223 ? -18.24557 2.53486   37.46300  1.000 63.94759  ? 223 PHE A CD2  1 
ATOM   3347 C CE1  . PHE A 1 223 ? -17.22842 3.88908   39.64197  1.000 66.64548  ? 223 PHE A CE1  1 
ATOM   3348 C CE2  . PHE A 1 223 ? -17.27128 3.49889   37.28203  1.000 64.18193  ? 223 PHE A CE2  1 
ATOM   3349 C CZ   . PHE A 1 223 ? -16.76212 4.17515   38.37553  1.000 64.89440  ? 223 PHE A CZ   1 
ATOM   3350 H H    . PHE A 1 223 ? -17.95594 -0.05598  40.29881  1.000 59.13382  ? 223 PHE A H    1 
ATOM   3351 H HA   . PHE A 1 223 ? -20.28263 1.16668   40.88792  1.000 56.88432  ? 223 PHE A HA   1 
ATOM   3352 H HB2  . PHE A 1 223 ? -19.60180 0.48539   38.25008  1.000 62.87691  ? 223 PHE A HB2  1 
ATOM   3353 H HB3  . PHE A 1 223 ? -20.63559 1.59709   38.71998  1.000 62.87691  ? 223 PHE A HB3  1 
ATOM   3354 H HD1  . PHE A 1 223 ? -18.52806 2.74680   40.66736  1.000 70.98995  ? 223 PHE A HD1  1 
ATOM   3355 H HD2  . PHE A 1 223 ? -18.58421 2.08041   36.72564  1.000 76.79121  ? 223 PHE A HD2  1 
ATOM   3356 H HE1  . PHE A 1 223 ? -16.88386 4.34032   40.37855  1.000 80.02868  ? 223 PHE A HE1  1 
ATOM   3357 H HE2  . PHE A 1 223 ? -16.95925 3.69199   36.42749  1.000 77.07242  ? 223 PHE A HE2  1 
ATOM   3358 H HZ   . PHE A 1 223 ? -16.10532 4.82284   38.25717  1.000 77.92738  ? 223 PHE A HZ   1 
ATOM   3359 N N    . THR A 1 224 ? -21.87277 -0.65228  40.02689  1.000 42.56882  ? 224 THR A N    1 
ATOM   3360 C CA   . THR A 1 224 ? -22.68990 -1.77675  39.63330  1.000 41.73032  ? 224 THR A CA   1 
ATOM   3361 C C    . THR A 1 224 ? -23.63554 -1.31298  38.53971  1.000 40.29888  ? 224 THR A C    1 
ATOM   3362 O O    . THR A 1 224 ? -23.58901 -0.16307  38.09346  1.000 39.69515  ? 224 THR A O    1 
ATOM   3363 C CB   . THR A 1 224 ? -23.47470 -2.36060  40.80221  1.000 40.25600  ? 224 THR A CB   1 
ATOM   3364 O OG1  . THR A 1 224 ? -24.02201 -3.61103  40.37456  1.000 40.57872  ? 224 THR A OG1  1 
ATOM   3365 C CG2  . THR A 1 224 ? -24.61408 -1.42770  41.19841  1.000 43.79710  ? 224 THR A CG2  1 
ATOM   3366 H H    . THR A 1 224 ? -22.31343 0.07720   40.14213  1.000 51.13669  ? 224 THR A H    1 
ATOM   3367 H HA   . THR A 1 224 ? -22.11253 -2.47745  39.29189  1.000 50.13048  ? 224 THR A HA   1 
ATOM   3368 H HB   . THR A 1 224 ? -22.90130 -2.47925  41.57553  1.000 48.36130  ? 224 THR A HB   1 
ATOM   3369 H HG1  . THR A 1 224 ? -24.28917 -4.05000  41.03904  1.000 48.74857  ? 224 THR A HG1  1 
ATOM   3370 H HG21 . THR A 1 224 ? -24.89004 -1.60973  42.11034  1.000 52.61062  ? 224 THR A HG21 1 
ATOM   3371 H HG22 . THR A 1 224 ? -24.32383 -0.50427  41.13572  1.000 52.61062  ? 224 THR A HG22 1 
ATOM   3372 H HG23 . THR A 1 224 ? -25.37202 -1.56024  40.60776  1.000 52.61062  ? 224 THR A HG23 1 
ATOM   3373 N N    . THR A 1 225 ? -24.48718 -2.22776  38.08034  1.000 40.72356  ? 225 THR A N    1 
ATOM   3374 C CA   . THR A 1 225 ? -25.45355 -1.91668  37.03769  1.000 45.75754  ? 225 THR A CA   1 
ATOM   3375 C C    . THR A 1 225 ? -26.66352 -2.82243  37.21072  1.000 42.89550  ? 225 THR A C    1 
ATOM   3376 O O    . THR A 1 225 ? -26.76475 -3.57945  38.19391  1.000 38.72325  ? 225 THR A O    1 
ATOM   3377 C CB   . THR A 1 225 ? -24.82317 -2.03834  35.63479  1.000 52.71417  ? 225 THR A CB   1 
ATOM   3378 O OG1  . THR A 1 225 ? -25.72194 -1.50665  34.65230  1.000 52.06867  ? 225 THR A OG1  1 
ATOM   3379 C CG2  . THR A 1 225 ? -24.51504 -3.49463  35.27621  1.000 47.17872  ? 225 THR A CG2  1 
ATOM   3380 H H    . THR A 1 225 ? -24.52276 -3.04013  38.36033  1.000 48.92237  ? 225 THR A H    1 
ATOM   3381 H HA   . THR A 1 225 ? -25.75255 -1.00021  37.14535  1.000 54.96315  ? 225 THR A HA   1 
ATOM   3382 H HB   . THR A 1 225 ? -23.98911 -1.54313  35.63123  1.000 63.31111  ? 225 THR A HB   1 
ATOM   3383 H HG1  . THR A 1 225 ? -25.31821 -1.39482  33.92422  1.000 62.53651  ? 225 THR A HG1  1 
ATOM   3384 H HG21 . THR A 1 225 ? -24.00162 -3.53238  34.45410  1.000 56.66857  ? 225 THR A HG21 1 
ATOM   3385 H HG22 . THR A 1 225 ? -24.00208 -3.90993  35.98706  1.000 56.66857  ? 225 THR A HG22 1 
ATOM   3386 H HG23 . THR A 1 225 ? -25.34113 -3.98823  35.15440  1.000 56.66857  ? 225 THR A HG23 1 
ATOM   3387 N N    . THR A 1 226 ? -27.60758 -2.70190  36.27162  1.000 48.34007  ? 226 THR A N    1 
ATOM   3388 C CA   . THR A 1 226 ? -28.80420 -3.52728  36.18361  1.000 48.04674  ? 226 THR A CA   1 
ATOM   3389 C C    . THR A 1 226 ? -28.74107 -4.37663  34.91899  1.000 46.12837  ? 226 THR A C    1 
ATOM   3390 O O    . THR A 1 226 ? -28.06701 -4.02401  33.94753  1.000 41.09898  ? 226 THR A O    1 
ATOM   3391 C CB   . THR A 1 226 ? -30.08737 -2.68262  36.12668  1.000 45.59163  ? 226 THR A CB   1 
ATOM   3392 O OG1  . THR A 1 226 ? -30.07191 -1.84672  34.95512  1.000 40.21872  ? 226 THR A OG1  1 
ATOM   3393 C CG2  . THR A 1 226 ? -30.23101 -1.81711  37.37048  1.000 46.59823  ? 226 THR A CG2  1 
ATOM   3394 H H    . THR A 1 226 ? -27.56994 -2.11591  35.64329  1.000 58.06219  ? 226 THR A H    1 
ATOM   3395 H HA   . THR A 1 226 ? -28.84519 -4.09293  36.97055  1.000 57.71018  ? 226 THR A HA   1 
ATOM   3396 H HB   . THR A 1 226 ? -30.85371 -3.27594  36.08689  1.000 54.76406  ? 226 THR A HB   1 
ATOM   3397 H HG1  . THR A 1 226 ? -29.69756 -1.11515  35.12908  1.000 48.31656  ? 226 THR A HG1  1 
ATOM   3398 H HG21 . THR A 1 226 ? -31.00121 -1.23416  37.28186  1.000 55.97198  ? 226 THR A HG21 1 
ATOM   3399 H HG22 . THR A 1 226 ? -30.34904 -2.37791  38.15308  1.000 55.97198  ? 226 THR A HG22 1 
ATOM   3400 H HG23 . THR A 1 226 ? -29.43669 -1.27330  37.48978  1.000 55.97198  ? 226 THR A HG23 1 
ATOM   3401 N N    . LEU A 1 227 ? -29.50191 -5.47927  34.91774  1.000 41.30159  ? 227 LEU A N    1 
ATOM   3402 C CA   . LEU A 1 227 ? -29.53568 -6.31309  33.71273  1.000 44.42780  ? 227 LEU A CA   1 
ATOM   3403 C C    . LEU A 1 227 ? -30.01112 -5.49516  32.52080  1.000 48.02050  ? 227 LEU A C    1 
ATOM   3404 O O    . LEU A 1 227 ? -29.39965 -5.53562  31.44673  1.000 47.42511  ? 227 LEU A O    1 
ATOM   3405 C CB   . LEU A 1 227 ? -30.41714 -7.54149  33.94391  1.000 47.60335  ? 227 LEU A CB   1 
ATOM   3406 C CG   . LEU A 1 227 ? -29.94010 -8.88318  33.37957  1.000 50.17903  ? 227 LEU A CG   1 
ATOM   3407 C CD1  . LEU A 1 227 ? -28.62663 -9.37214  33.98876  1.000 47.95687  ? 227 LEU A CD1  1 
ATOM   3408 C CD2  . LEU A 1 227 ? -30.99528 -9.96439  33.56239  1.000 50.18519  ? 227 LEU A CD2  1 
ATOM   3409 H H    . LEU A 1 227 ? -29.98632 -5.75388  35.57312  1.000 49.61601  ? 227 LEU A H    1 
ATOM   3410 H HA   . LEU A 1 227 ? -28.64457 -6.64146  33.51522  1.000 53.36747  ? 227 LEU A HA   1 
ATOM   3411 H HB2  . LEU A 1 227 ? -30.51233 -7.65995  34.90193  1.000 57.17812  ? 227 LEU A HB2  1 
ATOM   3412 H HB3  . LEU A 1 227 ? -31.28265 -7.36272  33.54411  1.000 57.17812  ? 227 LEU A HB3  1 
ATOM   3413 H HG   . LEU A 1 227 ? -29.78265 -8.72883  32.43496  1.000 60.26894  ? 227 LEU A HG   1 
ATOM   3414 H HD11 . LEU A 1 227 ? -27.90111 -8.81746  33.66188  1.000 57.60234  ? 227 LEU A HD11 1 
ATOM   3415 H HD12 . LEU A 1 227 ? -28.68317 -9.30727  34.95493  1.000 57.60234  ? 227 LEU A HD12 1 
ATOM   3416 H HD13 . LEU A 1 227 ? -28.48134 -10.29482 33.72712  1.000 57.60234  ? 227 LEU A HD13 1 
ATOM   3417 H HD21 . LEU A 1 227 ? -31.85030 -9.62679  33.25275  1.000 60.27633  ? 227 LEU A HD21 1 
ATOM   3418 H HD22 . LEU A 1 227 ? -30.74083 -10.74463 33.04530  1.000 60.27633  ? 227 LEU A HD22 1 
ATOM   3419 H HD23 . LEU A 1 227 ? -31.05162 -10.19486 34.50292  1.000 60.27633  ? 227 LEU A HD23 1 
ATOM   3420 N N    . ASN A 1 228 ? -31.06547 -4.69690  32.69799  1.000 51.97216  ? 228 ASN A N    1 
ATOM   3421 C CA   . ASN A 1 228 ? -31.56378 -3.91151  31.56833  1.000 49.91718  ? 228 ASN A CA   1 
ATOM   3422 C C    . ASN A 1 228 ? -30.60373 -2.77492  31.20956  1.000 50.27851  ? 228 ASN A C    1 
ATOM   3423 O O    . ASN A 1 228 ? -30.43137 -2.44193  30.02865  1.000 47.70652  ? 228 ASN A O    1 
ATOM   3424 C CB   . ASN A 1 228 ? -32.97025 -3.38251  31.87396  1.000 63.87162  ? 228 ASN A CB   1 
ATOM   3425 C CG   . ASN A 1 228 ? -34.07635 -4.38713  31.50586  1.000 56.95749  ? 228 ASN A CG   1 
ATOM   3426 O OD1  . ASN A 1 228 ? -33.79786 -5.51030  31.06251  1.000 58.33791  ? 228 ASN A OD1  1 
ATOM   3427 N ND2  . ASN A 1 228 ? -35.33305 -3.97834  31.68492  1.000 50.22245  ? 228 ASN A ND2  1 
ATOM   3428 H H    . ASN A 1 228 ? -31.49555 -4.59512  33.43574  1.000 62.42069  ? 228 ASN A H    1 
ATOM   3429 H HA   . ASN A 1 228 ? -31.63218 -4.48716  30.79061  1.000 59.95472  ? 228 ASN A HA   1 
ATOM   3430 H HB2  . ASN A 1 228 ? -33.03843 -3.19567  32.82335  1.000 76.70005  ? 228 ASN A HB2  1 
ATOM   3431 H HB3  . ASN A 1 228 ? -33.12044 -2.57085  31.36449  1.000 76.70005  ? 228 ASN A HB3  1 
ATOM   3432 H HD21 . ASN A 1 228 ? -35.98721 -4.50296  31.49401  1.000 60.32104  ? 228 ASN A HD21 1 
ATOM   3433 H HD22 . ASN A 1 228 ? -35.48930 -3.19011  31.99130  1.000 60.32104  ? 228 ASN A HD22 1 
ATOM   3434 N N    . ASP A 1 229 ? -29.95072 -2.17229  32.20524  1.000 48.10254  ? 229 ASP A N    1 
ATOM   3435 C CA   . ASP A 1 229 ? -28.94061 -1.16068  31.90151  1.000 50.01183  ? 229 ASP A CA   1 
ATOM   3436 C C    . ASP A 1 229 ? -27.76111 -1.78625  31.16022  1.000 53.84570  ? 229 ASP A C    1 
ATOM   3437 O O    . ASP A 1 229 ? -27.32142 -1.28776  30.11661  1.000 46.48788  ? 229 ASP A O    1 
ATOM   3438 C CB   . ASP A 1 229 ? -28.47316 -0.47435  33.19181  1.000 48.28457  ? 229 ASP A CB   1 
ATOM   3439 H H    . ASP A 1 229 ? -30.07095 -2.32721  33.04258  1.000 57.77714  ? 229 ASP A H    1 
ATOM   3440 H HA   . ASP A 1 229 ? -29.33366 -0.48055  31.33244  1.000 60.06829  ? 229 ASP A HA   1 
ATOM   3441 N N    . PHE A 1 230 ? -27.23569 -2.89107  31.68545  1.000 51.05008  ? 230 PHE A N    1 
ATOM   3442 C CA   . PHE A 1 230 ? -26.11820 -3.53048  31.00232  1.000 55.69888  ? 230 PHE A CA   1 
ATOM   3443 C C    . PHE A 1 230 ? -26.50031 -3.90186  29.57353  1.000 55.60146  ? 230 PHE A C    1 
ATOM   3444 O O    . PHE A 1 230 ? -25.78104 -3.57554  28.62422  1.000 52.14979  ? 230 PHE A O    1 
ATOM   3445 C CB   . PHE A 1 230 ? -25.65684 -4.75829  31.77049  1.000 49.69065  ? 230 PHE A CB   1 
ATOM   3446 C CG   . PHE A 1 230 ? -24.66228 -5.57020  31.01469  1.000 56.47560  ? 230 PHE A CG   1 
ATOM   3447 C CD1  . PHE A 1 230 ? -23.32635 -5.20046  30.98663  1.000 60.17081  ? 230 PHE A CD1  1 
ATOM   3448 C CD2  . PHE A 1 230 ? -25.06947 -6.67446  30.28999  1.000 52.64004  ? 230 PHE A CD2  1 
ATOM   3449 C CE1  . PHE A 1 230 ? -22.40026 -5.93670  30.26105  1.000 56.20259  ? 230 PHE A CE1  1 
ATOM   3450 C CE2  . PHE A 1 230 ? -24.14782 -7.41173  29.56071  1.000 54.31228  ? 230 PHE A CE2  1 
ATOM   3451 C CZ   . PHE A 1 230 ? -22.81583 -7.04027  29.54591  1.000 55.69041  ? 230 PHE A CZ   1 
ATOM   3452 H H    . PHE A 1 230 ? -27.49839 -3.27526  32.40862  1.000 61.31420  ? 230 PHE A H    1 
ATOM   3453 H HA   . PHE A 1 230 ? -25.37537 -2.90752  30.97043  1.000 66.89275  ? 230 PHE A HA   1 
ATOM   3454 H HB2  . PHE A 1 230 ? -25.24395 -4.47448  32.60108  1.000 59.68289  ? 230 PHE A HB2  1 
ATOM   3455 H HB3  . PHE A 1 230 ? -26.42455 -5.32109  31.95698  1.000 59.68289  ? 230 PHE A HB3  1 
ATOM   3456 H HD1  . PHE A 1 230 ? -23.04741 -4.44997  31.45976  1.000 72.25907  ? 230 PHE A HD1  1 
ATOM   3457 H HD2  . PHE A 1 230 ? -25.96526 -6.92438  30.29122  1.000 63.22215  ? 230 PHE A HD2  1 
ATOM   3458 H HE1  . PHE A 1 230 ? -21.50435 -5.68724  30.25711  1.000 67.49721  ? 230 PHE A HE1  1 
ATOM   3459 H HE2  . PHE A 1 230 ? -24.42654 -8.15780  29.08050  1.000 65.22884  ? 230 PHE A HE2  1 
ATOM   3460 H HZ   . PHE A 1 230 ? -22.20053 -7.53446  29.05390  1.000 66.88260  ? 230 PHE A HZ   1 
ATOM   3461 N N    . ASN A 1 231 ? -27.65419 -4.55322  29.40426  1.000 52.97958  ? 231 ASN A N    1 
ATOM   3462 C CA   . ASN A 1 231 ? -28.04806 -5.04768  28.08948  1.000 47.48922  ? 231 ASN A CA   1 
ATOM   3463 C C    . ASN A 1 231 ? -28.16748 -3.93598  27.06783  1.000 56.05645  ? 231 ASN A C    1 
ATOM   3464 O O    . ASN A 1 231 ? -28.02535 -4.18924  25.86884  1.000 58.12753  ? 231 ASN A O    1 
ATOM   3465 C CB   . ASN A 1 231 ? -29.36809 -5.79636  28.18600  1.000 47.07085  ? 231 ASN A CB   1 
ATOM   3466 C CG   . ASN A 1 231 ? -29.18009 -7.21556  28.65677  1.000 49.98512  ? 231 ASN A CG   1 
ATOM   3467 O OD1  . ASN A 1 231 ? -28.09637 -7.78357  28.49491  1.000 50.83598  ? 231 ASN A OD1  1 
ATOM   3468 N ND2  . ASN A 1 231 ? -30.20929 -7.78903  29.26089  1.000 50.51911  ? 231 ASN A ND2  1 
ATOM   3469 H H    . ASN A 1 231 ? -28.22025 -4.71930  30.03004  1.000 63.62959  ? 231 ASN A H    1 
ATOM   3470 H HA   . ASN A 1 231 ? -27.36253 -5.66216  27.78393  1.000 57.04117  ? 231 ASN A HA   1 
ATOM   3471 H HB2  . ASN A 1 231 ? -29.94705 -5.34178  28.81770  1.000 56.53912  ? 231 ASN A HB2  1 
ATOM   3472 H HB3  . ASN A 1 231 ? -29.78585 -5.82026  27.31089  1.000 56.53912  ? 231 ASN A HB3  1 
ATOM   3473 H HD21 . ASN A 1 231 ? -30.14475 -8.59809  29.54524  1.000 60.67704  ? 231 ASN A HD21 1 
ATOM   3474 H HD22 . ASN A 1 231 ? -30.94231 -7.35245  29.36894  1.000 60.67704  ? 231 ASN A HD22 1 
ATOM   3475 N N    . LEU A 1 232 ? -28.45871 -2.70601  27.51266  1.000 55.38003  ? 232 LEU A N    1 
ATOM   3476 C CA   . LEU A 1 232 ? -28.47603 -1.58510  26.58323  1.000 57.10877  ? 232 LEU A CA   1 
ATOM   3477 C C    . LEU A 1 232 ? -27.07816 -1.26922  26.08279  1.000 52.31634  ? 232 LEU A C    1 
ATOM   3478 O O    . LEU A 1 232 ? -26.91576 -0.69162  25.00199  1.000 54.84146  ? 232 LEU A O    1 
ATOM   3479 C CB   . LEU A 1 232 ? -29.06854 -0.34672  27.24946  1.000 62.22680  ? 232 LEU A CB   1 
ATOM   3480 C CG   . LEU A 1 232 ? -30.58708 -0.20613  27.18992  1.000 70.82699  ? 232 LEU A CG   1 
ATOM   3481 C CD1  . LEU A 1 232 ? -30.97034 1.09117   27.87624  1.000 89.12932  ? 232 LEU A CD1  1 
ATOM   3482 C CD2  . LEU A 1 232 ? -31.11559 -0.23471  25.76144  1.000 71.82861  ? 232 LEU A CD2  1 
ATOM   3483 H H    . LEU A 1 232 ? -28.64435 -2.50489  28.32795  1.000 66.51014  ? 232 LEU A H    1 
ATOM   3484 H HA   . LEU A 1 232 ? -29.03829 -1.81982  25.82847  1.000 68.58462  ? 232 LEU A HA   1 
ATOM   3485 H HB2  . LEU A 1 232 ? -28.81955 -0.36104  28.18685  1.000 74.72626  ? 232 LEU A HB2  1 
ATOM   3486 H HB3  . LEU A 1 232 ? -28.69207 0.43631   26.81813  1.000 74.72626  ? 232 LEU A HB3  1 
ATOM   3487 H HG   . LEU A 1 232 ? -30.99810 -0.95964  27.64180  1.000 85.04649  ? 232 LEU A HG   1 
ATOM   3488 H HD11 . LEU A 1 232 ? -31.93110 1.20943   27.81415  1.000 107.00928 ? 232 LEU A HD11 1 
ATOM   3489 H HD12 . LEU A 1 232 ? -30.70197 1.04712   28.80734  1.000 107.00928 ? 232 LEU A HD12 1 
ATOM   3490 H HD13 . LEU A 1 232 ? -30.51732 1.82721   27.43589  1.000 107.00928 ? 232 LEU A HD13 1 
ATOM   3491 H HD21 . LEU A 1 232 ? -32.04416 0.04576   25.76260  1.000 86.24844  ? 232 LEU A HD21 1 
ATOM   3492 H HD22 . LEU A 1 232 ? -30.58791 0.37058   25.21732  1.000 86.24844  ? 232 LEU A HD22 1 
ATOM   3493 H HD23 . LEU A 1 232 ? -31.04340 -1.13824  25.41602  1.000 86.24844  ? 232 LEU A HD23 1 
ATOM   3494 N N    . VAL A 1 233 ? -26.06791 -1.59425  26.88400  1.000 53.57282  ? 233 VAL A N    1 
ATOM   3495 C CA   . VAL A 1 233 ? -24.69255 -1.48507  26.42251  1.000 52.05159  ? 233 VAL A CA   1 
ATOM   3496 C C    . VAL A 1 233 ? -24.32217 -2.67025  25.54302  1.000 48.28840  ? 233 VAL A C    1 
ATOM   3497 O O    . VAL A 1 233 ? -23.59989 -2.51936  24.55223  1.000 49.71034  ? 233 VAL A O    1 
ATOM   3498 C CB   . VAL A 1 233 ? -23.74649 -1.36018  27.62831  1.000 55.21763  ? 233 VAL A CB   1 
ATOM   3499 C CG1  . VAL A 1 233 ? -22.33497 -1.00867  27.16570  1.000 61.55622  ? 233 VAL A CG1  1 
ATOM   3500 C CG2  . VAL A 1 233 ? -24.29057 -0.32326  28.59756  1.000 55.15764  ? 233 VAL A CG2  1 
ATOM   3501 H H    . VAL A 1 233 ? -26.15250 -1.87786  27.69147  1.000 64.34149  ? 233 VAL A H    1 
ATOM   3502 H HA   . VAL A 1 233 ? -24.60886 -0.68158  25.88557  1.000 62.51600  ? 233 VAL A HA   1 
ATOM   3503 H HB   . VAL A 1 233 ? -23.69267 -2.20963  28.09355  1.000 66.31525  ? 233 VAL A HB   1 
ATOM   3504 H HG11 . VAL A 1 233 ? -21.72843 -1.08132  27.91918  1.000 73.92157  ? 233 VAL A HG11 1 
ATOM   3505 H HG12 . VAL A 1 233 ? -22.06900 -1.62587  26.46625  1.000 73.92157  ? 233 VAL A HG12 1 
ATOM   3506 H HG13 . VAL A 1 233 ? -22.33140 -0.10065  26.82454  1.000 73.92157  ? 233 VAL A HG13 1 
ATOM   3507 H HG21 . VAL A 1 233 ? -24.93771 0.23216   28.13537  1.000 66.24326  ? 233 VAL A HG21 1 
ATOM   3508 H HG22 . VAL A 1 233 ? -24.71629 -0.77845  29.34084  1.000 66.24326  ? 233 VAL A HG22 1 
ATOM   3509 H HG23 . VAL A 1 233 ? -23.55680 0.22278   28.92056  1.000 66.24326  ? 233 VAL A HG23 1 
ATOM   3510 N N    . ALA A 1 234 ? -24.78297 -3.87137  25.89162  1.000 53.79212  ? 234 ALA A N    1 
ATOM   3511 C CA   . ALA A 1 234 ? -24.47809 -5.02546  25.04671  1.000 44.09047  ? 234 ALA A CA   1 
ATOM   3512 C C    . ALA A 1 234 ? -25.00141 -4.80277  23.63605  1.000 53.96379  ? 234 ALA A C    1 
ATOM   3513 O O    . ALA A 1 234 ? -24.32938 -5.13890  22.65268  1.000 53.30748  ? 234 ALA A O    1 
ATOM   3514 C CB   . ALA A 1 234 ? -25.07839 -6.29653  25.64729  1.000 48.38140  ? 234 ALA A CB   1 
ATOM   3515 H H    . ALA A 1 234 ? -25.25814 -4.04022  26.58826  1.000 64.60464  ? 234 ALA A H    1 
ATOM   3516 H HA   . ALA A 1 234 ? -23.51644 -5.14595  25.00661  1.000 52.96266  ? 234 ALA A HA   1 
ATOM   3517 H HB1  . ALA A 1 234 ? -24.92574 -7.03608  25.03847  1.000 58.11178  ? 234 ALA A HB1  1 
ATOM   3518 H HB2  . ALA A 1 234 ? -24.65069 -6.47576  26.49926  1.000 58.11178  ? 234 ALA A HB2  1 
ATOM   3519 H HB3  . ALA A 1 234 ? -26.03080 -6.16552  25.77637  1.000 58.11178  ? 234 ALA A HB3  1 
ATOM   3520 N N    . MET A 1 235 ? -26.20883 -4.23670  23.52485  1.000 57.85104  ? 235 MET A N    1 
ATOM   3521 C CA   . MET A 1 235 ? -26.77992 -3.88534  22.22991  1.000 54.34347  ? 235 MET A CA   1 
ATOM   3522 C C    . MET A 1 235 ? -25.78824 -3.10241  21.37715  1.000 51.49161  ? 235 MET A C    1 
ATOM   3523 O O    . MET A 1 235 ? -25.43840 -3.51200  20.26305  1.000 48.50783  ? 235 MET A O    1 
ATOM   3524 C CB   . MET A 1 235 ? -28.06400 -3.07043  22.44641  1.000 61.68592  ? 235 MET A CB   1 
ATOM   3525 H H    . MET A 1 235 ? -26.71793 -4.04603  24.19123  1.000 69.47535  ? 235 MET A H    1 
ATOM   3526 H HA   . MET A 1 235 ? -27.00883 -4.70315  21.76120  1.000 65.26627  ? 235 MET A HA   1 
ATOM   3527 N N    . LYS A 1 236 ? -25.32815 -1.95499  21.88354  1.000 53.56080  ? 236 LYS A N    1 
ATOM   3528 C CA   . LYS A 1 236 ? -24.43921 -1.11935  21.08734  1.000 56.41878  ? 236 LYS A CA   1 
ATOM   3529 C C    . LYS A 1 236 ? -23.22901 -1.90758  20.60642  1.000 54.27872  ? 236 LYS A C    1 
ATOM   3530 O O    . LYS A 1 236 ? -22.74036 -1.67914  19.49608  1.000 53.83208  ? 236 LYS A O    1 
ATOM   3531 C CB   . LYS A 1 236 ? -23.99832 0.11800   21.88688  1.000 53.41823  ? 236 LYS A CB   1 
ATOM   3532 H H    . LYS A 1 236 ? -25.51279 -1.64856  22.66559  1.000 64.32707  ? 236 LYS A H    1 
ATOM   3533 H HA   . LYS A 1 236 ? -24.92208 -0.79903  20.30944  1.000 67.75664  ? 236 LYS A HA   1 
ATOM   3534 N N    . TYR A 1 237 ? -22.76268 -2.87569  21.40017  1.000 56.08726  ? 237 TYR A N    1 
ATOM   3535 C CA   . TYR A 1 237 ? -21.48946 -3.54305  21.15748  1.000 47.46959  ? 237 TYR A CA   1 
ATOM   3536 C C    . TYR A 1 237 ? -21.65526 -4.93948  20.56484  1.000 49.12432  ? 237 TYR A C    1 
ATOM   3537 O O    . TYR A 1 237 ? -20.69682 -5.71679  20.53883  1.000 49.91866  ? 237 TYR A O    1 
ATOM   3538 C CB   . TYR A 1 237 ? -20.69080 -3.56509  22.46190  1.000 44.50914  ? 237 TYR A CB   1 
ATOM   3539 C CG   . TYR A 1 237 ? -20.20739 -2.16986  22.84207  1.000 46.35702  ? 237 TYR A CG   1 
ATOM   3540 C CD1  . TYR A 1 237 ? -18.99651 -1.67912  22.36131  1.000 55.58276  ? 237 TYR A CD1  1 
ATOM   3541 C CD2  . TYR A 1 237 ? -20.97492 -1.33939  23.63813  1.000 49.52383  ? 237 TYR A CD2  1 
ATOM   3542 C CE1  . TYR A 1 237 ? -18.55599 -0.39563  22.68937  1.000 58.17263  ? 237 TYR A CE1  1 
ATOM   3543 C CE2  . TYR A 1 237 ? -20.54221 -0.05656  23.97272  1.000 54.56068  ? 237 TYR A CE2  1 
ATOM   3544 C CZ   . TYR A 1 237 ? -19.33588 0.40517   23.50498  1.000 57.40707  ? 237 TYR A CZ   1 
ATOM   3545 O OH   . TYR A 1 237 ? -18.92797 1.67848   23.84883  1.000 57.20173  ? 237 TYR A OH   1 
ATOM   3546 H H    . TYR A 1 237 ? -23.17611 -3.16526  22.09646  1.000 67.35882  ? 237 TYR A H    1 
ATOM   3547 H HA   . TYR A 1 237 ? -20.97748 -3.04205  20.50344  1.000 57.01761  ? 237 TYR A HA   1 
ATOM   3548 H HB2  . TYR A 1 237 ? -21.25401 -3.89936  23.17741  1.000 53.46507  ? 237 TYR A HB2  1 
ATOM   3549 H HB3  . TYR A 1 237 ? -19.91597 -4.13862  22.35412  1.000 53.46507  ? 237 TYR A HB3  1 
ATOM   3550 H HD1  . TYR A 1 237 ? -18.47189 -2.21570  21.81199  1.000 66.75342  ? 237 TYR A HD1  1 
ATOM   3551 H HD2  . TYR A 1 237 ? -21.79477 -1.64197  23.95621  1.000 59.48270  ? 237 TYR A HD2  1 
ATOM   3552 H HE1  . TYR A 1 237 ? -17.74427 -0.08113  22.36212  1.000 69.86125  ? 237 TYR A HE1  1 
ATOM   3553 H HE2  . TYR A 1 237 ? -21.07027 0.48631   24.51248  1.000 65.52692  ? 237 TYR A HE2  1 
ATOM   3554 H HH   . TYR A 1 237 ? -18.23536 1.88385   23.42020  1.000 68.69618  ? 237 TYR A HH   1 
ATOM   3555 N N    . ASN A 1 238 ? -22.83430 -5.24336  20.03367  1.000 50.13230  ? 238 ASN A N    1 
ATOM   3556 C CA   . ASN A 1 238 ? -23.12873 -6.55211  19.45712  1.000 42.28952  ? 238 ASN A CA   1 
ATOM   3557 C C    . ASN A 1 238 ? -22.75622 -7.66170  20.42744  1.000 40.83064  ? 238 ASN A C    1 
ATOM   3558 O O    . ASN A 1 238 ? -22.23470 -8.69606  20.03540  1.000 41.00197  ? 238 ASN A O    1 
ATOM   3559 C CB   . ASN A 1 238 ? -22.42807 -6.72829  18.10774  1.000 44.61629  ? 238 ASN A CB   1 
ATOM   3560 C CG   . ASN A 1 238 ? -23.09372 -5.91581  16.98722  1.000 64.98253  ? 238 ASN A CG   1 
ATOM   3561 O OD1  . ASN A 1 238 ? -24.32230 -5.85526  16.89483  1.000 64.14580  ? 238 ASN A OD1  1 
ATOM   3562 N ND2  . ASN A 1 238 ? -22.28067 -5.28107  16.14397  1.000 64.58424  ? 238 ASN A ND2  1 
ATOM   3563 H H    . ASN A 1 238 ? -23.49664 -4.69626  19.99373  1.000 60.21286  ? 238 ASN A H    1 
ATOM   3564 H HA   . ASN A 1 238 ? -24.08336 -6.61511  19.29705  1.000 50.80152  ? 238 ASN A HA   1 
ATOM   3565 H HB2  . ASN A 1 238 ? -21.50774 -6.43248  18.18765  1.000 53.59364  ? 238 ASN A HB2  1 
ATOM   3566 H HB3  . ASN A 1 238 ? -22.45492 -7.66486  17.85674  1.000 53.59364  ? 238 ASN A HB3  1 
ATOM   3567 H HD21 . ASN A 1 238 ? -22.60818 -4.81364  15.50066  1.000 77.55519  ? 238 ASN A HD21 1 
ATOM   3568 H HD22 . ASN A 1 238 ? -21.42833 -5.33877  16.24296  1.000 77.55519  ? 238 ASN A HD22 1 
ATOM   3569 N N    . TYR A 1 239 ? -23.04968 -7.44807  21.70358  1.000 30.31041  ? 239 TYR A N    1 
ATOM   3570 C CA   . TYR A 1 239 ? -23.03248 -8.54056  22.65846  1.000 35.60288  ? 239 TYR A CA   1 
ATOM   3571 C C    . TYR A 1 239 ? -24.40179 -9.19521  22.80130  1.000 42.44845  ? 239 TYR A C    1 
ATOM   3572 O O    . TYR A 1 239 ? -25.44356 -8.54168  22.71552  1.000 39.55263  ? 239 TYR A O    1 
ATOM   3573 C CB   . TYR A 1 239 ? -22.56776 -8.03499  24.00933  1.000 31.67530  ? 239 TYR A CB   1 
ATOM   3574 C CG   . TYR A 1 239 ? -21.08527 -8.03326  24.22731  1.000 33.35434  ? 239 TYR A CG   1 
ATOM   3575 C CD1  . TYR A 1 239 ? -20.23448 -7.37200  23.35686  1.000 36.97618  ? 239 TYR A CD1  1 
ATOM   3576 C CD2  . TYR A 1 239 ? -20.54174 -8.66553  25.32971  1.000 33.86950  ? 239 TYR A CD2  1 
ATOM   3577 C CE1  . TYR A 1 239 ? -18.84354 -7.38333  23.56244  1.000 37.96385  ? 239 TYR A CE1  1 
ATOM   3578 C CE2  . TYR A 1 239 ? -19.18111 -8.64648  25.56641  1.000 37.45366  ? 239 TYR A CE2  1 
ATOM   3579 C CZ   . TYR A 1 239 ? -18.33092 -8.00819  24.67605  1.000 39.23641  ? 239 TYR A CZ   1 
ATOM   3580 O OH   . TYR A 1 239 ? -16.96986 -8.01746  24.92587  1.000 33.71589  ? 239 TYR A OH   1 
ATOM   3581 H H    . TYR A 1 239 ? -23.26021 -6.68342  22.03612  1.000 36.42659  ? 239 TYR A H    1 
ATOM   3582 H HA   . TYR A 1 239 ? -22.42134 -9.22377  22.34121  1.000 42.77755  ? 239 TYR A HA   1 
ATOM   3583 H HB2  . TYR A 1 239 ? -22.87517 -7.12101  24.11443  1.000 38.06446  ? 239 TYR A HB2  1 
ATOM   3584 H HB3  . TYR A 1 239 ? -22.95894 -8.59760  24.69588  1.000 38.06446  ? 239 TYR A HB3  1 
ATOM   3585 H HD1  . TYR A 1 239 ? -20.58746 -6.91510  22.62778  1.000 44.42552  ? 239 TYR A HD1  1 
ATOM   3586 H HD2  . TYR A 1 239 ? -21.10222 -9.11178  25.92269  1.000 40.69750  ? 239 TYR A HD2  1 
ATOM   3587 H HE1  . TYR A 1 239 ? -18.27540 -6.97237  22.95152  1.000 45.61072  ? 239 TYR A HE1  1 
ATOM   3588 H HE2  . TYR A 1 239 ? -18.83504 -9.06183  26.32313  1.000 44.99849  ? 239 TYR A HE2  1 
ATOM   3589 H HH   . TYR A 1 239 ? -16.56779 -7.56479  24.34361  1.000 40.51316  ? 239 TYR A HH   1 
ATOM   3590 N N    . GLU A 1 240 ? -24.39684 -10.50268 23.03752  1.000 37.42752  ? 240 GLU A N    1 
ATOM   3591 C CA   . GLU A 1 240 ? -25.65269 -11.17976 23.34050  1.000 40.37702  ? 240 GLU A CA   1 
ATOM   3592 C C    . GLU A 1 240 ? -26.24525 -10.64402 24.63901  1.000 38.91200  ? 240 GLU A C    1 
ATOM   3593 O O    . GLU A 1 240 ? -25.50682 -10.35041 25.58752  1.000 40.29892  ? 240 GLU A O    1 
ATOM   3594 C CB   . GLU A 1 240 ? -25.45017 -12.67941 23.49873  1.000 41.51987  ? 240 GLU A CB   1 
ATOM   3595 C CG   . GLU A 1 240 ? -25.18123 -13.41609 22.24083  1.000 50.43050  ? 240 GLU A CG   1 
ATOM   3596 C CD   . GLU A 1 240 ? -25.06978 -14.88036 22.55507  1.000 57.03581  ? 240 GLU A CD   1 
ATOM   3597 O OE1  . GLU A 1 240 ? -24.96060 -15.19210 23.77322  1.000 56.45855  ? 240 GLU A OE1  1 
ATOM   3598 O OE2  . GLU A 1 240 ? -25.11682 -15.70341 21.61757  1.000 63.63945  ? 240 GLU A OE2  1 
ATOM   3599 H H    . GLU A 1 240 ? -23.70051 -11.00731 23.02901  1.000 44.96713  ? 240 GLU A H    1 
ATOM   3600 H HA   . GLU A 1 240 ? -26.26524 -11.01621 22.60638  1.000 48.50653  ? 240 GLU A HA   1 
ATOM   3601 H HB2  . GLU A 1 240 ? -24.69363 -12.82574 24.08790  1.000 49.87794  ? 240 GLU A HB2  1 
ATOM   3602 H HB3  . GLU A 1 240 ? -26.25332 -13.05725 23.89000  1.000 49.87794  ? 240 GLU A HB3  1 
ATOM   3603 H HG2  . GLU A 1 240 ? -25.90992 -13.28078 21.61506  1.000 60.57070  ? 240 GLU A HG2  1 
ATOM   3604 H HG3  . GLU A 1 240 ? -24.34737 -13.11144 21.84997  1.000 60.57070  ? 240 GLU A HG3  1 
ATOM   3605 N N    . PRO A 1 241 ? -27.56559 -10.50532 24.73504  1.000 44.25092  ? 241 PRO A N    1 
ATOM   3606 C CA   . PRO A 1 241 ? -28.13691 -9.95686  25.96851  1.000 42.60047  ? 241 PRO A CA   1 
ATOM   3607 C C    . PRO A 1 241 ? -28.03649 -10.95622 27.10628  1.000 46.36540  ? 241 PRO A C    1 
ATOM   3608 O O    . PRO A 1 241 ? -28.15516 -12.16903 26.91316  1.000 38.90982  ? 241 PRO A O    1 
ATOM   3609 C CB   . PRO A 1 241 ? -29.59067 -9.64578  25.58410  1.000 48.83908  ? 241 PRO A CB   1 
ATOM   3610 C CG   . PRO A 1 241 ? -29.55395 -9.50007  24.07830  1.000 49.52008  ? 241 PRO A CG   1 
ATOM   3611 C CD   . PRO A 1 241 ? -28.53665 -10.51115 23.62555  1.000 46.68973  ? 241 PRO A CD   1 
ATOM   3612 H HA   . PRO A 1 241 ? -27.69786 -9.13139  26.22686  1.000 51.17466  ? 241 PRO A HA   1 
ATOM   3613 H HB2  . PRO A 1 241 ? -30.16971 -10.37681 25.85095  1.000 58.66100  ? 241 PRO A HB2  1 
ATOM   3614 H HB3  . PRO A 1 241 ? -29.87877 -8.82248  26.00845  1.000 58.66100  ? 241 PRO A HB3  1 
ATOM   3615 H HG2  . PRO A 1 241 ? -30.42773 -9.69357  23.70418  1.000 59.47819  ? 241 PRO A HG2  1 
ATOM   3616 H HG3  . PRO A 1 241 ? -29.28191 -8.60058  23.83788  1.000 59.47819  ? 241 PRO A HG3  1 
ATOM   3617 H HD2  . PRO A 1 241 ? -28.93946 -11.38721 23.51987  1.000 56.08178  ? 241 PRO A HD2  1 
ATOM   3618 H HD3  . PRO A 1 241 ? -28.11804 -10.23609 22.79488  1.000 56.08178  ? 241 PRO A HD3  1 
ATOM   3619 N N    . LEU A 1 242 ? -27.77157 -10.44045 28.29850  1.000 40.16467  ? 242 LEU A N    1 
ATOM   3620 C CA   . LEU A 1 242 ? -27.60367 -11.28439 29.46834  1.000 39.21325  ? 242 LEU A CA   1 
ATOM   3621 C C    . LEU A 1 242 ? -28.95771 -11.52713 30.13673  1.000 47.56239  ? 242 LEU A C    1 
ATOM   3622 O O    . LEU A 1 242 ? -29.81048 -10.63581 30.20123  1.000 45.88837  ? 242 LEU A O    1 
ATOM   3623 C CB   . LEU A 1 242 ? -26.62449 -10.64555 30.44695  1.000 41.51277  ? 242 LEU A CB   1 
ATOM   3624 C CG   . LEU A 1 242 ? -26.04262 -11.61314 31.47438  1.000 35.49033  ? 242 LEU A CG   1 
ATOM   3625 C CD1  . LEU A 1 242 ? -24.99304 -12.53204 30.87119  1.000 43.86454  ? 242 LEU A CD1  1 
ATOM   3626 C CD2  . LEU A 1 242 ? -25.47219 -10.84604 32.61281  1.000 44.71507  ? 242 LEU A CD2  1 
ATOM   3627 H H    . LEU A 1 242 ? -27.68405 -9.59935  28.45501  1.000 48.25171  ? 242 LEU A H    1 
ATOM   3628 H HA   . LEU A 1 242 ? -27.24198 -12.14576 29.20736  1.000 47.11000  ? 242 LEU A HA   1 
ATOM   3629 H HB2  . LEU A 1 242 ? -25.88493 -10.27045 29.94370  1.000 49.86943  ? 242 LEU A HB2  1 
ATOM   3630 H HB3  . LEU A 1 242 ? -27.08581 -9.94341  30.93180  1.000 49.86943  ? 242 LEU A HB3  1 
ATOM   3631 H HG   . LEU A 1 242 ? -26.75691 -12.18485 31.79661  1.000 42.64250  ? 242 LEU A HG   1 
ATOM   3632 H HD11 . LEU A 1 242 ? -24.55624 -13.02354 31.58430  1.000 52.69155  ? 242 LEU A HD11 1 
ATOM   3633 H HD12 . LEU A 1 242 ? -25.42664 -13.14933 30.26139  1.000 52.69155  ? 242 LEU A HD12 1 
ATOM   3634 H HD13 . LEU A 1 242 ? -24.34198 -11.99607 30.39187  1.000 52.69155  ? 242 LEU A HD13 1 
ATOM   3635 H HD21 . LEU A 1 242 ? -24.94923 -11.44594 33.16737  1.000 53.71218  ? 242 LEU A HD21 1 
ATOM   3636 H HD22 . LEU A 1 242 ? -24.90621 -10.13910 32.26524  1.000 53.71218  ? 242 LEU A HD22 1 
ATOM   3637 H HD23 . LEU A 1 242 ? -26.19759 -10.46421 33.13136  1.000 53.71218  ? 242 LEU A HD23 1 
ATOM   3638 N N    . THR A 1 243 ? -29.13255 -12.74423 30.64110  1.000 46.11947  ? 243 THR A N    1 
ATOM   3639 C CA   . THR A 1 243 ? -30.38789 -13.22021 31.19679  1.000 47.74100  ? 243 THR A CA   1 
ATOM   3640 C C    . THR A 1 243 ? -30.13629 -13.79073 32.57936  1.000 40.93008  ? 243 THR A C    1 
ATOM   3641 O O    . THR A 1 243 ? -29.00099 -14.10648 32.94185  1.000 42.30720  ? 243 THR A O    1 
ATOM   3642 C CB   . THR A 1 243 ? -30.97836 -14.32620 30.34062  1.000 41.62466  ? 243 THR A CB   1 
ATOM   3643 O OG1  . THR A 1 243 ? -30.19366 -15.50261 30.56969  1.000 41.89267  ? 243 THR A OG1  1 
ATOM   3644 C CG2  . THR A 1 243 ? -30.91800 -13.94994 28.88636  1.000 44.67264  ? 243 THR A CG2  1 
ATOM   3645 H H    . THR A 1 243 ? -28.50968 -13.33637 30.67271  1.000 55.39746  ? 243 THR A H    1 
ATOM   3646 H HA   . THR A 1 243 ? -31.01119 -12.47929 31.25549  1.000 57.34330  ? 243 THR A HA   1 
ATOM   3647 H HB   . THR A 1 243 ? -31.90921 -14.48532 30.56221  1.000 50.00370  ? 243 THR A HB   1 
ATOM   3648 H HG1  . THR A 1 243 ? -30.54558 -15.96981 31.17258  1.000 50.32530  ? 243 THR A HG1  1 
ATOM   3649 H HG21 . THR A 1 243 ? -31.46145 -14.55966 28.36309  1.000 53.66126  ? 243 THR A HG21 1 
ATOM   3650 H HG22 . THR A 1 243 ? -31.25050 -13.04707 28.76319  1.000 53.66126  ? 243 THR A HG22 1 
ATOM   3651 H HG23 . THR A 1 243 ? -30.00209 -13.99400 28.57001  1.000 53.66126  ? 243 THR A HG23 1 
ATOM   3652 N N    . GLN A 1 244 ? -31.21752 -13.96417 33.35044  1.000 37.82853  ? 244 GLN A N    1 
ATOM   3653 C CA   . GLN A 1 244 ? -31.06136 -14.54783 34.67687  1.000 44.37087  ? 244 GLN A CA   1 
ATOM   3654 C C    . GLN A 1 244 ? -30.47609 -15.95991 34.59701  1.000 38.81350  ? 244 GLN A C    1 
ATOM   3655 O O    . GLN A 1 244 ? -29.64215 -16.34212 35.42923  1.000 44.84719  ? 244 GLN A O    1 
ATOM   3656 C CB   . GLN A 1 244 ? -32.41007 -14.51750 35.40368  1.000 52.32932  ? 244 GLN A CB   1 
ATOM   3657 C CG   . GLN A 1 244 ? -32.36772 -14.86374 36.89994  1.000 43.50741  ? 244 GLN A CG   1 
ATOM   3658 C CD   . GLN A 1 244 ? -31.43564 -13.97380 37.70809  1.000 43.18979  ? 244 GLN A CD   1 
ATOM   3659 O OE1  . GLN A 1 244 ? -31.46548 -12.73781 37.60513  1.000 48.83217  ? 244 GLN A OE1  1 
ATOM   3660 N NE2  . GLN A 1 244 ? -30.58810 -14.60105 38.51016  1.000 46.09504  ? 244 GLN A NE2  1 
ATOM   3661 H H    . GLN A 1 244 ? -32.02336 -13.75774 33.13224  1.000 45.44834  ? 244 GLN A H    1 
ATOM   3662 H HA   . GLN A 1 244 ? -30.43760 -14.02019 35.19977  1.000 53.29915  ? 244 GLN A HA   1 
ATOM   3663 H HB2  . GLN A 1 244 ? -32.77797 -13.62340 35.32534  1.000 62.84929  ? 244 GLN A HB2  1 
ATOM   3664 H HB3  . GLN A 1 244 ? -33.00043 -15.15777 34.97657  1.000 62.84929  ? 244 GLN A HB3  1 
ATOM   3665 H HG2  . GLN A 1 244 ? -33.26018 -14.76875 37.26790  1.000 52.26299  ? 244 GLN A HG2  1 
ATOM   3666 H HG3  . GLN A 1 244 ? -32.06325 -15.77925 37.00018  1.000 52.26299  ? 244 GLN A HG3  1 
ATOM   3667 H HE21 . GLN A 1 244 ? -30.58901 -15.46015 38.54953  1.000 55.36815  ? 244 GLN A HE21 1 
ATOM   3668 H HE22 . GLN A 1 244 ? -30.03699 -14.14913 38.99147  1.000 55.36815  ? 244 GLN A HE22 1 
ATOM   3669 N N    . ASP A 1 245 ? -30.84372 -16.73931 33.57638  1.000 44.44736  ? 245 ASP A N    1 
ATOM   3670 C CA   . ASP A 1 245 ? -30.20521 -18.04567 33.42572  1.000 41.54989  ? 245 ASP A CA   1 
ATOM   3671 C C    . ASP A 1 245 ? -28.68553 -17.91433 33.35126  1.000 41.75403  ? 245 ASP A C    1 
ATOM   3672 O O    . ASP A 1 245 ? -27.95273 -18.69082 33.99067  1.000 42.06124  ? 245 ASP A O    1 
ATOM   3673 C CB   . ASP A 1 245 ? -30.73500 -18.75773 32.18664  1.000 46.91820  ? 245 ASP A CB   1 
ATOM   3674 C CG   . ASP A 1 245 ? -32.20578 -19.03955 32.27955  1.000 57.49301  ? 245 ASP A CG   1 
ATOM   3675 O OD1  . ASP A 1 245 ? -32.61376 -19.68861 33.26886  1.000 52.28610  ? 245 ASP A OD1  1 
ATOM   3676 O OD2  . ASP A 1 245 ? -32.95406 -18.56555 31.39742  1.000 80.39537  ? 245 ASP A OD2  1 
ATOM   3677 H H    . ASP A 1 245 ? -31.43483 -16.54296 32.98339  1.000 53.39093  ? 245 ASP A H    1 
ATOM   3678 H HA   . ASP A 1 245 ? -30.42746 -18.58609 34.19996  1.000 49.91397  ? 245 ASP A HA   1 
ATOM   3679 H HB2  . ASP A 1 245 ? -30.58300 -18.19840 31.40886  1.000 56.35595  ? 245 ASP A HB2  1 
ATOM   3680 H HB3  . ASP A 1 245 ? -30.27121 -19.60334 32.08293  1.000 56.35595  ? 245 ASP A HB3  1 
ATOM   3681 N N    . HIS A 1 246 ? -28.19629 -16.94361 32.57845  1.000 43.49403  ? 246 HIS A N    1 
ATOM   3682 C CA   . HIS A 1 246 ? -26.76519 -16.65001 32.56039  1.000 41.26343  ? 246 HIS A CA   1 
ATOM   3683 C C    . HIS A 1 246 ? -26.26649 -16.26480 33.94958  1.000 38.20482  ? 246 HIS A C    1 
ATOM   3684 O O    . HIS A 1 246 ? -25.23627 -16.77624 34.42306  1.000 37.17987  ? 246 HIS A O    1 
ATOM   3685 C CB   . HIS A 1 246 ? -26.46180 -15.51271 31.58049  1.000 39.83785  ? 246 HIS A CB   1 
ATOM   3686 C CG   . HIS A 1 246 ? -26.76087 -15.82956 30.15140  1.000 38.98366  ? 246 HIS A CG   1 
ATOM   3687 N ND1  . HIS A 1 246 ? -27.18387 -14.86790 29.25921  1.000 40.72899  ? 246 HIS A ND1  1 
ATOM   3688 C CD2  . HIS A 1 246 ? -26.66907 -16.98333 29.44623  1.000 41.29479  ? 246 HIS A CD2  1 
ATOM   3689 C CE1  . HIS A 1 246 ? -27.35405 -15.41723 28.06651  1.000 43.56017  ? 246 HIS A CE1  1 
ATOM   3690 N NE2  . HIS A 1 246 ? -27.05023 -16.69906 28.15424  1.000 44.53228  ? 246 HIS A NE2  1 
ATOM   3691 H H    . HIS A 1 246 ? -28.66763 -16.44496 32.05999  1.000 52.24693  ? 246 HIS A H    1 
ATOM   3692 H HA   . HIS A 1 246 ? -26.29999 -17.44791 32.26401  1.000 49.57021  ? 246 HIS A HA   1 
ATOM   3693 H HB2  . HIS A 1 246 ? -26.99579 -14.74147 31.82738  1.000 47.85952  ? 246 HIS A HB2  1 
ATOM   3694 H HB3  . HIS A 1 246 ? -25.51825 -15.29609 31.64114  1.000 47.85952  ? 246 HIS A HB3  1 
ATOM   3695 H HD2  . HIS A 1 246 ? -26.39941 -17.81105 29.77344  1.000 49.60784  ? 246 HIS A HD2  1 
ATOM   3696 H HE1  . HIS A 1 246 ? -27.63868 -14.97597 27.29893  1.000 52.32630  ? 246 HIS A HE1  1 
ATOM   3697 H HE2  . HIS A 1 246 ? -27.08487 -17.26550 27.50806  1.000 53.49284  ? 246 HIS A HE2  1 
ATOM   3698 N N    . VAL A 1 247 ? -26.95999 -15.33273 34.60847  1.000 40.76667  ? 247 VAL A N    1 
ATOM   3699 C CA   . VAL A 1 247 ? -26.61107 -15.01210 35.99174  1.000 35.34480  ? 247 VAL A CA   1 
ATOM   3700 C C    . VAL A 1 247 ? -26.51680 -16.28716 36.83196  1.000 36.44580  ? 247 VAL A C    1 
ATOM   3701 O O    . VAL A 1 247 ? -25.54650 -16.49261 37.57612  1.000 44.05304  ? 247 VAL A O    1 
ATOM   3702 C CB   . VAL A 1 247 ? -27.60568 -13.99406 36.56884  1.000 38.10899  ? 247 VAL A CB   1 
ATOM   3703 C CG1  . VAL A 1 247 ? -27.23321 -13.67064 37.97814  1.000 42.52611  ? 247 VAL A CG1  1 
ATOM   3704 C CG2  . VAL A 1 247 ? -27.61271 -12.70888 35.71003  1.000 39.76734  ? 247 VAL A CG2  1 
ATOM   3705 H H    . VAL A 1 247 ? -27.61883 -14.88423 34.28540  1.000 48.97411  ? 247 VAL A H    1 
ATOM   3706 H HA   . VAL A 1 247 ? -25.73327 -14.59964 36.00738  1.000 42.46786  ? 247 VAL A HA   1 
ATOM   3707 H HB   . VAL A 1 247 ? -28.49855 -14.37299 36.55895  1.000 45.78489  ? 247 VAL A HB   1 
ATOM   3708 H HG11 . VAL A 1 247 ? -27.82323 -12.97550 38.30914  1.000 51.08544  ? 247 VAL A HG11 1 
ATOM   3709 H HG12 . VAL A 1 247 ? -27.32615 -14.46939 38.52060  1.000 51.08544  ? 247 VAL A HG12 1 
ATOM   3710 H HG13 . VAL A 1 247 ? -26.31392 -13.36181 37.99890  1.000 51.08544  ? 247 VAL A HG13 1 
ATOM   3711 H HG21 . VAL A 1 247 ? -28.22268 -12.06737 36.10664  1.000 47.77491  ? 247 VAL A HG21 1 
ATOM   3712 H HG22 . VAL A 1 247 ? -26.71564 -12.34073 35.68522  1.000 47.77491  ? 247 VAL A HG22 1 
ATOM   3713 H HG23 . VAL A 1 247 ? -27.90413 -12.93084 34.81186  1.000 47.77491  ? 247 VAL A HG23 1 
ATOM   3714 N N    . ASP A 1 248 ? -27.50519 -17.19179 36.69780  1.000 40.69553  ? 248 ASP A N    1 
ATOM   3715 C CA   . ASP A 1 248 ? -27.50163 -18.41473 37.50532  1.000 45.31982  ? 248 ASP A CA   1 
ATOM   3716 C C    . ASP A 1 248 ? -26.33245 -19.31017 37.15810  1.000 44.21369  ? 248 ASP A C    1 
ATOM   3717 O O    . ASP A 1 248 ? -25.70011 -19.90548 38.04110  1.000 41.07349  ? 248 ASP A O    1 
ATOM   3718 C CB   . ASP A 1 248 ? -28.78966 -19.20516 37.30015  1.000 44.57602  ? 248 ASP A CB   1 
ATOM   3719 C CG   . ASP A 1 248 ? -29.95872 -18.60356 38.00326  1.000 44.21098  ? 248 ASP A CG   1 
ATOM   3720 O OD1  . ASP A 1 248 ? -29.76307 -17.71551 38.87340  1.000 47.70837  ? 248 ASP A OD1  1 
ATOM   3721 O OD2  . ASP A 1 248 ? -31.07958 -19.03545 37.68933  1.000 45.25446  ? 248 ASP A OD2  1 
ATOM   3722 H H    . ASP A 1 248 ? -28.17100 -17.11890 36.15838  1.000 48.88874  ? 248 ASP A H    1 
ATOM   3723 H HA   . ASP A 1 248 ? -27.43858 -18.14424 38.43471  1.000 54.43788  ? 248 ASP A HA   1 
ATOM   3724 H HB2  . ASP A 1 248 ? -28.99366 -19.23531 36.35232  1.000 53.54532  ? 248 ASP A HB2  1 
ATOM   3725 H HB3  . ASP A 1 248 ? -28.66558 -20.10457 37.64157  1.000 53.54532  ? 248 ASP A HB3  1 
ATOM   3726 N N    . ILE A 1 249 ? -26.05039 -19.44272 35.86527  1.000 44.46621  ? 249 ILE A N    1 
ATOM   3727 C CA   . ILE A 1 249 ? -24.90565 -20.22521 35.43073  1.000 42.06998  ? 249 ILE A CA   1 
ATOM   3728 C C    . ILE A 1 249 ? -23.61899 -19.68178 36.03277  1.000 37.32187  ? 249 ILE A C    1 
ATOM   3729 O O    . ILE A 1 249 ? -22.69722 -20.44817 36.34214  1.000 40.61847  ? 249 ILE A O    1 
ATOM   3730 C CB   . ILE A 1 249 ? -24.85039 -20.23962 33.88151  1.000 44.02013  ? 249 ILE A CB   1 
ATOM   3731 C CG1  . ILE A 1 249 ? -25.95479 -21.14597 33.30887  1.000 41.34310  ? 249 ILE A CG1  1 
ATOM   3732 C CG2  . ILE A 1 249 ? -23.48888 -20.69764 33.44224  1.000 44.77181  ? 249 ILE A CG2  1 
ATOM   3733 C CD1  . ILE A 1 249 ? -26.47903 -20.73432 31.90066  1.000 42.43180  ? 249 ILE A CD1  1 
ATOM   3734 H H    . ILE A 1 249 ? -26.50457 -19.09100 35.22525  1.000 53.41355  ? 249 ILE A H    1 
ATOM   3735 H HA   . ILE A 1 249 ? -25.00902 -21.13766 35.74322  1.000 50.53807  ? 249 ILE A HA   1 
ATOM   3736 H HB   . ILE A 1 249 ? -25.00676 -19.34334 33.54516  1.000 52.87826  ? 249 ILE A HB   1 
ATOM   3737 H HG12 . ILE A 1 249 ? -25.60534 -22.04797 33.23690  1.000 49.66582  ? 249 ILE A HG12 1 
ATOM   3738 H HG13 . ILE A 1 249 ? -26.71067 -21.13053 33.91658  1.000 49.66582  ? 249 ILE A HG13 1 
ATOM   3739 H HG21 . ILE A 1 249 ? -23.22649 -21.46448 33.97516  1.000 53.78028  ? 249 ILE A HG21 1 
ATOM   3740 H HG22 . ILE A 1 249 ? -23.52566 -20.94342 32.50461  1.000 53.78028  ? 249 ILE A HG22 1 
ATOM   3741 H HG23 . ILE A 1 249 ? -22.85580 -19.97389 33.56989  1.000 53.78028  ? 249 ILE A HG23 1 
ATOM   3742 H HD11 . ILE A 1 249 ? -26.67646 -19.78463 31.90239  1.000 50.97226  ? 249 ILE A HD11 1 
ATOM   3743 H HD12 . ILE A 1 249 ? -25.79593 -20.92896 31.24007  1.000 50.97226  ? 249 ILE A HD12 1 
ATOM   3744 H HD13 . ILE A 1 249 ? -27.28350 -21.23905 31.70321  1.000 50.97226  ? 249 ILE A HD13 1 
ATOM   3745 N N    . LEU A 1 250 ? -23.52679 -18.35585 36.20596  1.000 43.42683  ? 250 LEU A N    1 
ATOM   3746 C CA   . LEU A 1 250 ? -22.33357 -17.71924 36.75502  1.000 41.46778  ? 250 LEU A CA   1 
ATOM   3747 C C    . LEU A 1 250 ? -22.25169 -17.81947 38.27645  1.000 48.38588  ? 250 LEU A C    1 
ATOM   3748 O O    . LEU A 1 250 ? -21.20065 -17.50577 38.85649  1.000 46.89370  ? 250 LEU A O    1 
ATOM   3749 C CB   . LEU A 1 250 ? -22.30238 -16.25844 36.31801  1.000 39.17368  ? 250 LEU A CB   1 
ATOM   3750 C CG   . LEU A 1 250 ? -22.00932 -16.09390 34.81190  1.000 40.58415  ? 250 LEU A CG   1 
ATOM   3751 C CD1  . LEU A 1 250 ? -22.19565 -14.67958 34.30293  1.000 37.84133  ? 250 LEU A CD1  1 
ATOM   3752 C CD2  . LEU A 1 250 ? -20.57741 -16.56549 34.48950  1.000 36.10573  ? 250 LEU A CD2  1 
ATOM   3753 H H    . LEU A 1 250 ? -24.15287 -17.80013 36.00899  1.000 52.16629  ? 250 LEU A H    1 
ATOM   3754 H HA   . LEU A 1 250 ? -21.54243 -18.15536 36.40176  1.000 49.81543  ? 250 LEU A HA   1 
ATOM   3755 H HB2  . LEU A 1 250 ? -23.16516 -15.85552 36.50287  1.000 47.06252  ? 250 LEU A HB2  1 
ATOM   3756 H HB3  . LEU A 1 250 ? -21.60758 -15.79617 36.81243  1.000 47.06252  ? 250 LEU A HB3  1 
ATOM   3757 H HG   . LEU A 1 250 ? -22.65841 -16.64384 34.34590  1.000 48.75509  ? 250 LEU A HG   1 
ATOM   3758 H HD11 . LEU A 1 250 ? -23.10696 -14.39797 34.47929  1.000 45.46369  ? 250 LEU A HD11 1 
ATOM   3759 H HD12 . LEU A 1 250 ? -21.57369 -14.09405 34.76252  1.000 45.46369  ? 250 LEU A HD12 1 
ATOM   3760 H HD13 . LEU A 1 250 ? -22.02284 -14.66205 33.34861  1.000 45.46369  ? 250 LEU A HD13 1 
ATOM   3761 H HD21 . LEU A 1 250 ? -20.25953 -16.09502 33.70305  1.000 43.38097  ? 250 LEU A HD21 1 
ATOM   3762 H HD22 . LEU A 1 250 ? -20.00282 -16.37060 35.24631  1.000 43.38097  ? 250 LEU A HD22 1 
ATOM   3763 H HD23 . LEU A 1 250 ? -20.58992 -17.52067 34.32101  1.000 43.38097  ? 250 LEU A HD23 1 
ATOM   3764 N N    . GLY A 1 251 ? -23.31997 -18.25780 38.92319  1.000 42.40261  ? 251 GLY A N    1 
ATOM   3765 C CA   . GLY A 1 251 ? -23.39830 -18.28262 40.36452  1.000 48.47377  ? 251 GLY A CA   1 
ATOM   3766 C C    . GLY A 1 251 ? -22.18465 -18.87245 41.04811  1.000 48.92109  ? 251 GLY A C    1 
ATOM   3767 O O    . GLY A 1 251 ? -21.56846 -18.24071 41.91084  1.000 53.72048  ? 251 GLY A O    1 
ATOM   3768 H H    . GLY A 1 251 ? -24.02874 -18.55292 38.53569  1.000 50.93724  ? 251 GLY A H    1 
ATOM   3769 H HA2  . GLY A 1 251 ? -23.50871 -17.37468 40.68757  1.000 58.22262  ? 251 GLY A HA2  1 
ATOM   3770 H HA3  . GLY A 1 251 ? -24.17080 -18.80731 40.62692  1.000 58.22262  ? 251 GLY A HA3  1 
ATOM   3771 N N    . PRO A 1 252 ? -21.83114 -20.10699 40.69176  1.000 48.36399  ? 252 PRO A N    1 
ATOM   3772 C CA   . PRO A 1 252 ? -20.62840 -20.71897 41.29849  1.000 50.79803  ? 252 PRO A CA   1 
ATOM   3773 C C    . PRO A 1 252 ? -19.39640 -19.85406 41.22081  1.000 51.30782  ? 252 PRO A C    1 
ATOM   3774 O O    . PRO A 1 252 ? -18.63397 -19.76037 42.19305  1.000 50.12732  ? 252 PRO A O    1 
ATOM   3775 C CB   . PRO A 1 252 ? -20.46981 -22.00593 40.47512  1.000 48.79794  ? 252 PRO A CB   1 
ATOM   3776 C CG   . PRO A 1 252 ? -21.88232 -22.37158 40.13449  1.000 49.26416  ? 252 PRO A CG   1 
ATOM   3777 C CD   . PRO A 1 252 ? -22.62445 -21.08059 39.92065  1.000 51.79390  ? 252 PRO A CD   1 
ATOM   3778 H HA   . PRO A 1 252 ? -20.80110 -20.93476 42.22828  1.000 61.01174  ? 252 PRO A HA   1 
ATOM   3779 H HB2  . PRO A 1 252 ? -19.94698 -21.83312 39.67657  1.000 58.61163  ? 252 PRO A HB2  1 
ATOM   3780 H HB3  . PRO A 1 252 ? -20.04439 -22.69644 41.00721  1.000 58.61163  ? 252 PRO A HB3  1 
ATOM   3781 H HG2  . PRO A 1 252 ? -21.89182 -22.90749 39.32602  1.000 59.17110  ? 252 PRO A HG2  1 
ATOM   3782 H HG3  . PRO A 1 252 ? -22.27315 -22.87122 40.86832  1.000 59.17110  ? 252 PRO A HG3  1 
ATOM   3783 H HD2  . PRO A 1 252 ? -22.64310 -20.84404 38.98012  1.000 62.20678  ? 252 PRO A HD2  1 
ATOM   3784 H HD3  . PRO A 1 252 ? -23.52903 -21.14037 40.26570  1.000 62.20678  ? 252 PRO A HD3  1 
ATOM   3785 N N    . LEU A 1 253 ? -19.15262 -19.23016 40.07441  1.000 53.43327  ? 253 LEU A N    1 
ATOM   3786 C CA   . LEU A 1 253 ? -18.00667 -18.34490 39.94537  1.000 55.07434  ? 253 LEU A CA   1 
ATOM   3787 C C    . LEU A 1 253 ? -18.22081 -17.06449 40.73663  1.000 51.45584  ? 253 LEU A C    1 
ATOM   3788 O O    . LEU A 1 253 ? -17.28419 -16.54960 41.36202  1.000 48.89258  ? 253 LEU A O    1 
ATOM   3789 C CB   . LEU A 1 253 ? -17.74886 -18.01455 38.47426  1.000 52.85059  ? 253 LEU A CB   1 
ATOM   3790 C CG   . LEU A 1 253 ? -17.09577 -19.11430 37.63412  1.000 46.80703  ? 253 LEU A CG   1 
ATOM   3791 C CD1  . LEU A 1 253 ? -17.12297 -18.72884 36.15900  1.000 41.44425  ? 253 LEU A CD1  1 
ATOM   3792 C CD2  . LEU A 1 253 ? -15.68898 -19.33623 38.12280  1.000 52.46091  ? 253 LEU A CD2  1 
ATOM   3793 H H    . LEU A 1 253 ? -19.63103 -19.30198 39.36338  1.000 64.17402  ? 253 LEU A H    1 
ATOM   3794 H HA   . LEU A 1 253 ? -17.22342 -18.80025 40.29189  1.000 66.14331  ? 253 LEU A HA   1 
ATOM   3795 H HB2  . LEU A 1 253 ? -18.60034 -17.80588 38.05914  1.000 63.47481  ? 253 LEU A HB2  1 
ATOM   3796 H HB3  . LEU A 1 253 ? -17.16366 -17.24182 38.43758  1.000 63.47481  ? 253 LEU A HB3  1 
ATOM   3797 H HG   . LEU A 1 253 ? -17.58279 -19.94850 37.72263  1.000 56.22254  ? 253 LEU A HG   1 
ATOM   3798 H HD11 . LEU A 1 253 ? -16.64721 -19.40210 35.64784  1.000 49.78720  ? 253 LEU A HD11 1 
ATOM   3799 H HD12 . LEU A 1 253 ? -18.04522 -18.67893 35.86258  1.000 49.78720  ? 253 LEU A HD12 1 
ATOM   3800 H HD13 . LEU A 1 253 ? -16.69336 -17.86601 36.05009  1.000 49.78720  ? 253 LEU A HD13 1 
ATOM   3801 H HD21 . LEU A 1 253 ? -15.21139 -18.49215 38.10429  1.000 63.00719  ? 253 LEU A HD21 1 
ATOM   3802 H HD22 . LEU A 1 253 ? -15.72007 -19.67887 39.02973  1.000 63.00719  ? 253 LEU A HD22 1 
ATOM   3803 H HD23 . LEU A 1 253 ? -15.25030 -19.97730 37.54186  1.000 63.00719  ? 253 LEU A HD23 1 
ATOM   3804 N N    . SER A 1 254 ? -19.43914 -16.52402 40.69612  1.000 53.65224  ? 254 SER A N    1 
ATOM   3805 C CA   . SER A 1 254 ? -19.75074 -15.33718 41.48955  1.000 49.32322  ? 254 SER A CA   1 
ATOM   3806 C C    . SER A 1 254 ? -19.51885 -15.59937 42.96927  1.000 50.54136  ? 254 SER A C    1 
ATOM   3807 O O    . SER A 1 254 ? -18.92044 -14.77992 43.67142  1.000 49.43926  ? 254 SER A O    1 
ATOM   3808 C CB   . SER A 1 254 ? -21.19231 -14.90138 41.24982  1.000 53.26698  ? 254 SER A CB   1 
ATOM   3809 O OG   . SER A 1 254 ? -21.44073 -13.65160 41.87950  1.000 55.37620  ? 254 SER A OG   1 
ATOM   3810 H H    . SER A 1 254 ? -20.09381 -16.82100 40.22409  1.000 64.43679  ? 254 SER A H    1 
ATOM   3811 H HA   . SER A 1 254 ? -19.16781 -14.61510 41.20727  1.000 59.24197  ? 254 SER A HA   1 
ATOM   3812 H HB2  . SER A 1 254 ? -21.34305 -14.81224 40.29576  1.000 63.97447  ? 254 SER A HB2  1 
ATOM   3813 H HB3  . SER A 1 254 ? -21.79177 -15.56838 41.61951  1.000 63.97447  ? 254 SER A HB3  1 
ATOM   3814 H HG   . SER A 1 254 ? -21.03081 -13.03981 41.47542  1.000 66.50554  ? 254 SER A HG   1 
ATOM   3815 N N    . ALA A 1 255 ? -19.98813 -16.74837 43.46077  1.000 51.26805  ? 255 ALA A N    1 
ATOM   3816 C CA   . ALA A 1 255 ? -19.83247 -17.06333 44.87513  1.000 54.30699  ? 255 ALA A CA   1 
ATOM   3817 C C    . ALA A 1 255 ? -18.38748 -17.40583 45.20306  1.000 57.76039  ? 255 ALA A C    1 
ATOM   3818 O O    . ALA A 1 255 ? -17.86643 -16.98183 46.24199  1.000 62.38268  ? 255 ALA A O    1 
ATOM   3819 C CB   . ALA A 1 255 ? -20.76192 -18.21455 45.26478  1.000 65.88507  ? 255 ALA A CB   1 
ATOM   3820 H H    . ALA A 1 255 ? -20.39393 -17.35171 43.00151  1.000 61.57577  ? 255 ALA A H    1 
ATOM   3821 H HA   . ALA A 1 255 ? -20.08539 -16.28710 45.39896  1.000 65.22249  ? 255 ALA A HA   1 
ATOM   3822 H HB1  . ALA A 1 255 ? -20.67304 -18.38417 46.21569  1.000 79.11619  ? 255 ALA A HB1  1 
ATOM   3823 H HB2  . ALA A 1 255 ? -21.67633 -17.96629 45.05712  1.000 79.11619  ? 255 ALA A HB2  1 
ATOM   3824 H HB3  . ALA A 1 255 ? -20.51192 -19.00602 44.76281  1.000 79.11619  ? 255 ALA A HB3  1 
ATOM   3825 N N    . GLN A 1 256 ? -17.71720 -18.15259 44.32200  1.000 56.26192  ? 256 GLN A N    1 
ATOM   3826 C CA   . GLN A 1 256 ? -16.31182 -18.48957 44.53753  1.000 53.71395  ? 256 GLN A CA   1 
ATOM   3827 C C    . GLN A 1 256 ? -15.39765 -17.26814 44.51288  1.000 57.72778  ? 256 GLN A C    1 
ATOM   3828 O O    . GLN A 1 256 ? -14.24164 -17.37374 44.94363  1.000 61.99937  ? 256 GLN A O    1 
ATOM   3829 C CB   . GLN A 1 256 ? -15.85470 -19.51101 43.48435  1.000 56.79083  ? 256 GLN A CB   1 
ATOM   3830 C CG   . GLN A 1 256 ? -14.35533 -19.51775 43.20416  1.000 63.85013  ? 256 GLN A CG   1 
ATOM   3831 C CD   . GLN A 1 256 ? -13.95272 -20.54199 42.15674  1.000 70.64949  ? 256 GLN A CD   1 
ATOM   3832 O OE1  . GLN A 1 256 ? -14.79230 -21.05608 41.41409  1.000 75.48653  ? 256 GLN A OE1  1 
ATOM   3833 N NE2  . GLN A 1 256 ? -12.66196 -20.84387 42.09492  1.000 65.16918  ? 256 GLN A NE2  1 
ATOM   3834 H H    . GLN A 1 256 ? -18.05146 -18.47347 43.59749  1.000 67.56841  ? 256 GLN A H    1 
ATOM   3835 H HA   . GLN A 1 256 ? -16.22509 -18.89517 45.41438  1.000 64.51085  ? 256 GLN A HA   1 
ATOM   3836 H HB2  . GLN A 1 256 ? -16.09757 -20.39853 43.79132  1.000 68.20310  ? 256 GLN A HB2  1 
ATOM   3837 H HB3  . GLN A 1 256 ? -16.30620 -19.31387 42.64878  1.000 68.20310  ? 256 GLN A HB3  1 
ATOM   3838 H HG2  . GLN A 1 256 ? -14.09065 -18.64159 42.88292  1.000 76.67425  ? 256 GLN A HG2  1 
ATOM   3839 H HG3  . GLN A 1 256 ? -13.88217 -19.72717 44.02462  1.000 76.67425  ? 256 GLN A HG3  1 
ATOM   3840 H HE21 . GLN A 1 256 ? -12.10569 -20.46534 42.63053  1.000 78.25712  ? 256 GLN A HE21 1 
ATOM   3841 H HE22 . GLN A 1 256 ? -12.38174 -21.41804 41.51924  1.000 78.25712  ? 256 GLN A HE22 1 
ATOM   3842 N N    . THR A 1 257 ? -15.86273 -16.12029 44.00043  1.000 53.56417  ? 257 THR A N    1 
ATOM   3843 C CA   . THR A 1 257 ? -15.05888 -14.90438 44.03729  1.000 57.32080  ? 257 THR A CA   1 
ATOM   3844 C C    . THR A 1 257 ? -15.64838 -13.79123 44.90502  1.000 51.41049  ? 257 THR A C    1 
ATOM   3845 O O    . THR A 1 257 ? -14.96017 -12.80186 45.15172  1.000 54.56521  ? 257 THR A O    1 
ATOM   3846 C CB   . THR A 1 257 ? -14.84038 -14.32216 42.62299  1.000 50.76658  ? 257 THR A CB   1 
ATOM   3847 O OG1  . THR A 1 257 ? -16.09310 -13.90856 42.06039  1.000 48.38044  ? 257 THR A OG1  1 
ATOM   3848 C CG2  . THR A 1 257 ? -14.16664 -15.32364 41.71422  1.000 66.52025  ? 257 THR A CG2  1 
ATOM   3849 H H    . THR A 1 257 ? -16.63388 -16.02784 43.63112  1.000 64.33111  ? 257 THR A H    1 
ATOM   3850 H HA   . THR A 1 257 ? -14.19470 -15.15746 44.39790  1.000 68.83906  ? 257 THR A HA   1 
ATOM   3851 H HB   . THR A 1 257 ? -14.25666 -13.55022 42.68840  1.000 60.97399  ? 257 THR A HB   1 
ATOM   3852 H HG1  . THR A 1 257 ? -16.54310 -14.58125 41.83547  1.000 58.11063  ? 257 THR A HG1  1 
ATOM   3853 H HG21 . THR A 1 257 ? -13.25534 -15.47808 42.00846  1.000 79.87840  ? 257 THR A HG21 1 
ATOM   3854 H HG22 . THR A 1 257 ? -14.64973 -16.16461 41.73127  1.000 79.87840  ? 257 THR A HG22 1 
ATOM   3855 H HG23 . THR A 1 257 ? -14.15103 -14.98796 40.80429  1.000 79.87840  ? 257 THR A HG23 1 
ATOM   3856 N N    . GLY A 1 258 ? -16.90330 -13.89682 45.32677  1.000 50.64331  ? 258 GLY A N    1 
ATOM   3857 C CA   . GLY A 1 258 ? -17.49655 -12.79744 46.06383  1.000 46.15548  ? 258 GLY A CA   1 
ATOM   3858 C C    . GLY A 1 258 ? -17.85642 -11.57970 45.24668  1.000 51.38776  ? 258 GLY A C    1 
ATOM   3859 O O    . GLY A 1 258 ? -18.13131 -10.52573 45.82795  1.000 51.03798  ? 258 GLY A O    1 
ATOM   3860 H H    . GLY A 1 258 ? -17.41507 -14.57643 45.20097  1.000 60.82607  ? 258 GLY A H    1 
ATOM   3861 H HA2  . GLY A 1 258 ? -18.30891 -13.11504 46.48822  1.000 55.44067  ? 258 GLY A HA2  1 
ATOM   3862 H HA3  . GLY A 1 258 ? -16.87163 -12.51479 46.74975  1.000 55.44067  ? 258 GLY A HA3  1 
ATOM   3863 N N    . ILE A 1 259 ? -17.86378 -11.67333 43.91503  1.000 46.25126  ? 259 ILE A N    1 
ATOM   3864 C CA   . ILE A 1 259 ? -18.19923 -10.53856 43.06371  1.000 49.90275  ? 259 ILE A CA   1 
ATOM   3865 C C    . ILE A 1 259 ? -19.56321 -10.79524 42.45876  1.000 51.94388  ? 259 ILE A C    1 
ATOM   3866 O O    . ILE A 1 259 ? -19.71509 -11.69424 41.61711  1.000 46.54177  ? 259 ILE A O    1 
ATOM   3867 C CB   . ILE A 1 259 ? -17.17754 -10.29754 41.94235  1.000 43.47539  ? 259 ILE A CB   1 
ATOM   3868 C CG1  . ILE A 1 259 ? -15.77949 -10.21722 42.53383  1.000 47.75863  ? 259 ILE A CG1  1 
ATOM   3869 C CG2  . ILE A 1 259 ? -17.60143 -9.04454  41.13169  1.000 42.63589  ? 259 ILE A CG2  1 
ATOM   3870 C CD1  . ILE A 1 259 ? -14.71065 -10.11776 41.51379  1.000 57.83159  ? 259 ILE A CD1  1 
ATOM   3871 H H    . ILE A 1 259 ? -17.67563 -12.39200 43.48177  1.000 55.55562  ? 259 ILE A H    1 
ATOM   3872 H HA   . ILE A 1 259 ? -18.23264 -9.75153  43.62972  1.000 59.93740  ? 259 ILE A HA   1 
ATOM   3873 H HB   . ILE A 1 259 ? -17.15922 -11.03907 41.31729  1.000 52.22457  ? 259 ILE A HB   1 
ATOM   3874 H HG12 . ILE A 1 259 ? -15.72401 -9.43135  43.09973  1.000 57.36446  ? 259 ILE A HG12 1 
ATOM   3875 H HG13 . ILE A 1 259 ? -15.61562 -11.01628 43.05876  1.000 57.36446  ? 259 ILE A HG13 1 
ATOM   3876 H HG21 . ILE A 1 259 ? -18.44207 -9.22773  40.68374  1.000 51.21717  ? 259 ILE A HG21 1 
ATOM   3877 H HG22 . ILE A 1 259 ? -17.70676 -8.29594  41.73948  1.000 51.21717  ? 259 ILE A HG22 1 
ATOM   3878 H HG23 . ILE A 1 259 ? -16.91432 -8.84477  40.47681  1.000 51.21717  ? 259 ILE A HG23 1 
ATOM   3879 H HD11 . ILE A 1 259 ? -14.80266 -9.27578  41.04103  1.000 69.45201  ? 259 ILE A HD11 1 
ATOM   3880 H HD12 . ILE A 1 259 ? -13.84795 -10.15653 41.95554  1.000 69.45201  ? 259 ILE A HD12 1 
ATOM   3881 H HD13 . ILE A 1 259 ? -14.79752 -10.85734 40.89221  1.000 69.45201  ? 259 ILE A HD13 1 
ATOM   3882 N N    . ALA A 1 260 ? -20.54421 -9.99089  42.86039  1.000 44.23587  ? 260 ALA A N    1 
ATOM   3883 C CA   . ALA A 1 260 ? -21.87157 -10.10456 42.28071  1.000 50.06317  ? 260 ALA A CA   1 
ATOM   3884 C C    . ALA A 1 260 ? -21.76481 -10.00634 40.76488  1.000 45.14975  ? 260 ALA A C    1 
ATOM   3885 O O    . ALA A 1 260 ? -20.91023 -9.29486  40.23387  1.000 40.66711  ? 260 ALA A O    1 
ATOM   3886 C CB   . ALA A 1 260 ? -22.78602 -9.01395  42.84449  1.000 51.35929  ? 260 ALA A CB   1 
ATOM   3887 H H    . ALA A 1 260 ? -20.46491 -9.37948  43.45996  1.000 53.13714  ? 260 ALA A H    1 
ATOM   3888 H HA   . ALA A 1 260 ? -22.27365 -10.95774 42.50726  1.000 60.12990  ? 260 ALA A HA   1 
ATOM   3889 H HB1  . ALA A 1 260 ? -23.67226 -9.11701  42.46389  1.000 61.68525  ? 260 ALA A HB1  1 
ATOM   3890 H HB2  . ALA A 1 260 ? -22.82781 -9.10448  43.80935  1.000 61.68525  ? 260 ALA A HB2  1 
ATOM   3891 H HB3  . ALA A 1 260 ? -22.42391 -8.14539  42.60913  1.000 61.68525  ? 260 ALA A HB3  1 
ATOM   3892 N N    . VAL A 1 261 ? -22.61094 -10.77066 40.07673  1.000 40.68430  ? 261 VAL A N    1 
ATOM   3893 C CA   . VAL A 1 261 ? -22.57941 -10.80406 38.61977  1.000 45.82443  ? 261 VAL A CA   1 
ATOM   3894 C C    . VAL A 1 261 ? -22.78889 -9.41291  38.05162  1.000 44.49811  ? 261 VAL A C    1 
ATOM   3895 O O    . VAL A 1 261 ? -22.13946 -9.01352  37.07037  1.000 35.55216  ? 261 VAL A O    1 
ATOM   3896 C CB   . VAL A 1 261 ? -23.64148 -11.79822 38.10645  1.000 45.03154  ? 261 VAL A CB   1 
ATOM   3897 C CG1  . VAL A 1 261 ? -23.89965 -11.60102 36.61293  1.000 47.57296  ? 261 VAL A CG1  1 
ATOM   3898 C CG2  . VAL A 1 261 ? -23.20977 -13.21885 38.39937  1.000 48.46910  ? 261 VAL A CG2  1 
ATOM   3899 H H    . VAL A 1 261 ? -23.21027 -11.27700 40.42889  1.000 48.87527  ? 261 VAL A H    1 
ATOM   3900 H HA   . VAL A 1 261 ? -21.70618 -11.10888 38.32744  1.000 55.04342  ? 261 VAL A HA   1 
ATOM   3901 H HB   . VAL A 1 261 ? -24.47739 -11.63214 38.56966  1.000 54.09194  ? 261 VAL A HB   1 
ATOM   3902 H HG11 . VAL A 1 261 ? -24.38651 -10.77211 36.48335  1.000 57.14165  ? 261 VAL A HG11 1 
ATOM   3903 H HG12 . VAL A 1 261 ? -23.04926 -11.56130 36.14799  1.000 57.14165  ? 261 VAL A HG12 1 
ATOM   3904 H HG13 . VAL A 1 261 ? -24.42320 -12.34739 36.28169  1.000 57.14165  ? 261 VAL A HG13 1 
ATOM   3905 H HG21 . VAL A 1 261 ? -22.44746 -13.20000 38.99889  1.000 58.21703  ? 261 VAL A HG21 1 
ATOM   3906 H HG22 . VAL A 1 261 ? -23.94634 -13.69327 38.81566  1.000 58.21703  ? 261 VAL A HG22 1 
ATOM   3907 H HG23 . VAL A 1 261 ? -22.96526 -13.65261 37.56692  1.000 58.21703  ? 261 VAL A HG23 1 
ATOM   3908 N N    . LEU A 1 262 ? -23.69445 -8.64031  38.65911  1.000 40.55842  ? 262 LEU A N    1 
ATOM   3909 C CA   . LEU A 1 262 ? -23.96105 -7.31241  38.12488  1.000 40.62731  ? 262 LEU A CA   1 
ATOM   3910 C C    . LEU A 1 262 ? -22.81387 -6.35569  38.43105  1.000 32.34201  ? 262 LEU A C    1 
ATOM   3911 O O    . LEU A 1 262 ? -22.61032 -5.38568  37.69664  1.000 35.00241  ? 262 LEU A O    1 
ATOM   3912 C CB   . LEU A 1 262 ? -25.29069 -6.79585  38.68695  1.000 48.69335  ? 262 LEU A CB   1 
ATOM   3913 C CG   . LEU A 1 262 ? -26.52391 -7.59678  38.25357  1.000 44.11215  ? 262 LEU A CG   1 
ATOM   3914 C CD1  . LEU A 1 262 ? -27.75852 -7.11335  39.01508  1.000 55.82693  ? 262 LEU A CD1  1 
ATOM   3915 C CD2  . LEU A 1 262 ? -26.72987 -7.47316  36.75436  1.000 36.01956  ? 262 LEU A CD2  1 
ATOM   3916 H H    . LEU A 1 262 ? -24.14925 -8.85705  39.35609  1.000 48.72420  ? 262 LEU A H    1 
ATOM   3917 H HA   . LEU A 1 262 ? -24.04975 -7.35473  37.15987  1.000 48.80688  ? 262 LEU A HA   1 
ATOM   3918 H HB2  . LEU A 1 262 ? -25.24752 -6.82609  39.65552  1.000 58.48612  ? 262 LEU A HB2  1 
ATOM   3919 H HB3  . LEU A 1 262 ? -25.41596 -5.88134  38.38884  1.000 58.48612  ? 262 LEU A HB3  1 
ATOM   3920 H HG   . LEU A 1 262 ? -26.39160 -8.53523  38.46023  1.000 52.98868  ? 262 LEU A HG   1 
ATOM   3921 H HD11 . LEU A 1 262 ? -28.51689 -7.66667  38.77093  1.000 67.04642  ? 262 LEU A HD11 1 
ATOM   3922 H HD12 . LEU A 1 262 ? -27.59002 -7.18473  39.96766  1.000 67.04642  ? 262 LEU A HD12 1 
ATOM   3923 H HD13 . LEU A 1 262 ? -27.93364 -6.18908  38.77849  1.000 67.04642  ? 262 LEU A HD13 1 
ATOM   3924 H HD21 . LEU A 1 262 ? -27.61071 -7.81029  36.52774  1.000 43.27757  ? 262 LEU A HD21 1 
ATOM   3925 H HD22 . LEU A 1 262 ? -26.65796 -6.53942  36.50164  1.000 43.27757  ? 262 LEU A HD22 1 
ATOM   3926 H HD23 . LEU A 1 262 ? -26.04944 -7.99264  36.29822  1.000 43.27757  ? 262 LEU A HD23 1 
ATOM   3927 N N    . ASP A 1 263 ? -22.06029 -6.60859  39.50232  1.000 31.36373  ? 263 ASP A N    1 
ATOM   3928 C CA   . ASP A 1 263 ? -20.82115 -5.84455  39.68532  1.000 37.52150  ? 263 ASP A CA   1 
ATOM   3929 C C    . ASP A 1 263 ? -19.83159 -6.17608  38.57721  1.000 34.70699  ? 263 ASP A C    1 
ATOM   3930 O O    . ASP A 1 263 ? -19.16345 -5.29786  38.03560  1.000 36.65015  ? 263 ASP A O    1 
ATOM   3931 C CB   . ASP A 1 263 ? -20.19576 -6.14798  41.04314  1.000 41.00443  ? 263 ASP A CB   1 
ATOM   3932 C CG   . ASP A 1 263 ? -21.03143 -5.61487  42.22179  1.000 40.73037  ? 263 ASP A CG   1 
ATOM   3933 O OD1  . ASP A 1 263 ? -22.15238 -5.10934  41.99253  1.000 43.92666  ? 263 ASP A OD1  1 
ATOM   3934 O OD2  . ASP A 1 263 ? -20.57671 -5.73673  43.37920  1.000 42.93478  ? 263 ASP A OD2  1 
ATOM   3935 H H    . ASP A 1 263 ? -22.23372 -7.19014  40.11168  1.000 37.69057  ? 263 ASP A H    1 
ATOM   3936 H HA   . ASP A 1 263 ? -21.03113 -4.89787  39.66078  1.000 45.07990  ? 263 ASP A HA   1 
ATOM   3937 H HB2  . ASP A 1 263 ? -20.11404 -7.10915  41.14499  1.000 49.25942  ? 263 ASP A HB2  1 
ATOM   3938 H HB3  . ASP A 1 263 ? -19.31955 -5.73410  41.08635  1.000 49.25942  ? 263 ASP A HB3  1 
ATOM   3939 N N    . MET A 1 264 ? -19.73275 -7.44281  38.21138  1.000 37.17398  ? 264 MET A N    1 
ATOM   3940 C CA   . MET A 1 264 ? -18.83803 -7.78496  37.10811  1.000 39.38297  ? 264 MET A CA   1 
ATOM   3941 C C    . MET A 1 264 ? -19.34707 -7.19265  35.80191  1.000 35.38260  ? 264 MET A C    1 
ATOM   3942 O O    . MET A 1 264 ? -18.55726 -6.71441  34.98404  1.000 41.92881  ? 264 MET A O    1 
ATOM   3943 C CB   . MET A 1 264 ? -18.67304 -9.29656  36.99976  1.000 45.08545  ? 264 MET A CB   1 
ATOM   3944 C CG   . MET A 1 264 ? -17.50355 -9.70537  36.07751  1.000 42.00583  ? 264 MET A CG   1 
ATOM   3945 S SD   . MET A 1 264 ? -15.86577 -9.21612  36.68879  1.000 39.89638  ? 264 MET A SD   1 
ATOM   3946 C CE   . MET A 1 264 ? -15.49007 -10.64729 37.68426  1.000 41.21084  ? 264 MET A CE   1 
ATOM   3947 H H    . MET A 1 264 ? -20.15416 -8.10216  38.56814  1.000 44.66288  ? 264 MET A H    1 
ATOM   3948 H HA   . MET A 1 264 ? -17.95854 -7.42150  37.29593  1.000 47.31366  ? 264 MET A HA   1 
ATOM   3949 H HB2  . MET A 1 264 ? -18.50031 -9.65933  37.88263  1.000 54.15664  ? 264 MET A HB2  1 
ATOM   3950 H HB3  . MET A 1 264 ? -19.48828 -9.67795  36.63805  1.000 54.15664  ? 264 MET A HB3  1 
ATOM   3951 H HG2  . MET A 1 264 ? -17.50544 -10.67079 35.98340  1.000 50.46110  ? 264 MET A HG2  1 
ATOM   3952 H HG3  . MET A 1 264 ? -17.63059 -9.28736  35.21146  1.000 50.46110  ? 264 MET A HG3  1 
ATOM   3953 H HE1  . MET A 1 264 ? -14.71079 -10.45692 38.22959  1.000 49.50711  ? 264 MET A HE1  1 
ATOM   3954 H HE2  . MET A 1 264 ? -16.25095 -10.84540 38.25235  1.000 49.50711  ? 264 MET A HE2  1 
ATOM   3955 H HE3  . MET A 1 264 ? -15.30889 -11.39985 37.09969  1.000 49.50711  ? 264 MET A HE3  1 
ATOM   3956 N N    . CYS A 1 265 ? -20.66754 -7.20277  35.58422  1.000 39.02458  ? 265 CYS A N    1 
ATOM   3957 C CA   . CYS A 1 265 ? -21.22432 -6.51948  34.42108  1.000 38.37854  ? 265 CYS A CA   1 
ATOM   3958 C C    . CYS A 1 265 ? -20.80102 -5.06449  34.35948  1.000 40.57092  ? 265 CYS A C    1 
ATOM   3959 O O    . CYS A 1 265 ? -20.53109 -4.51972  33.27220  1.000 38.36373  ? 265 CYS A O    1 
ATOM   3960 C CB   . CYS A 1 265 ? -22.74768 -6.60864  34.44633  1.000 39.72082  ? 265 CYS A CB   1 
ATOM   3961 S SG   . CYS A 1 265 ? -23.35701 -8.28381  34.10224  1.000 37.87323  ? 265 CYS A SG   1 
ATOM   3962 H H    . CYS A 1 265 ? -21.24785 -7.59090  36.08641  1.000 46.88360  ? 265 CYS A H    1 
ATOM   3963 H HA   . CYS A 1 265 ? -20.89452 -6.96358  33.62427  1.000 46.10835  ? 265 CYS A HA   1 
ATOM   3964 H HB2  . CYS A 1 265 ? -23.06478 -6.34788  35.32517  1.000 47.71909  ? 265 CYS A HB2  1 
ATOM   3965 H HB3  . CYS A 1 265 ? -23.11015 -6.01245  33.77248  1.000 47.71909  ? 265 CYS A HB3  1 
ATOM   3966 H HG   . CYS A 1 265 ? -23.04075 -9.00778  35.00549  1.000 45.50198  ? 265 CYS A HG   1 
ATOM   3967 N N    . ALA A 1 266 ? -20.79040 -4.38884  35.51255  1.000 39.03197  ? 266 ALA A N    1 
ATOM   3968 C CA   . ALA A 1 266 ? -20.42150 -2.97717  35.51756  1.000 41.01667  ? 266 ALA A CA   1 
ATOM   3969 C C    . ALA A 1 266 ? -18.98185 -2.79348  35.07409  1.000 41.22742  ? 266 ALA A C    1 
ATOM   3970 O O    . ALA A 1 266 ? -18.66514 -1.84534  34.35190  1.000 40.69095  ? 266 ALA A O    1 
ATOM   3971 C CB   . ALA A 1 266 ? -20.63500 -2.38103  36.90998  1.000 41.11727  ? 266 ALA A CB   1 
ATOM   3972 H H    . ALA A 1 266 ? -20.98745 -4.71734  36.28252  1.000 46.89247  ? 266 ALA A H    1 
ATOM   3973 H HA   . ALA A 1 266 ? -20.99504 -2.49903  34.89842  1.000 49.27411  ? 266 ALA A HA   1 
ATOM   3974 H HB1  . ALA A 1 266 ? -20.07685 -2.85564  37.54568  1.000 49.39483  ? 266 ALA A HB1  1 
ATOM   3975 H HB2  . ALA A 1 266 ? -20.39149 -1.44226  36.89232  1.000 49.39483  ? 266 ALA A HB2  1 
ATOM   3976 H HB3  . ALA A 1 266 ? -21.56890 -2.47597  37.15435  1.000 49.39483  ? 266 ALA A HB3  1 
ATOM   3977 N N    . SER A 1 267 ? -18.09676 -3.70565  35.48848  1.000 42.14006  ? 267 SER A N    1 
ATOM   3978 C CA   . SER A 1 267 ? -16.72669 -3.69674  34.98720  1.000 45.90345  ? 267 SER A CA   1 
ATOM   3979 C C    . SER A 1 267 ? -16.68318 -3.91309  33.48288  1.000 41.73830  ? 267 SER A C    1 
ATOM   3980 O O    . SER A 1 267 ? -15.94509 -3.22813  32.77423  1.000 37.73111  ? 267 SER A O    1 
ATOM   3981 C CB   . SER A 1 267 ? -15.90171 -4.77624  35.67748  1.000 43.33133  ? 267 SER A CB   1 
ATOM   3982 O OG   . SER A 1 267 ? -15.55563 -4.37684  36.98806  1.000 48.83109  ? 267 SER A OG   1 
ATOM   3983 H H    . SER A 1 267 ? -18.26518 -4.33214  36.05306  1.000 50.62218  ? 267 SER A H    1 
ATOM   3984 H HA   . SER A 1 267 ? -16.34174 -2.82984  35.19019  1.000 55.13825  ? 267 SER A HA   1 
ATOM   3985 H HB2  . SER A 1 267 ? -16.42328 -5.59282  35.72272  1.000 52.05170  ? 267 SER A HB2  1 
ATOM   3986 H HB3  . SER A 1 267 ? -15.09028 -4.92863  35.16831  1.000 52.05170  ? 267 SER A HB3  1 
ATOM   3987 H HG   . SER A 1 267 ? -15.24681 -5.03067  37.41554  1.000 58.65141  ? 267 SER A HG   1 
ATOM   3988 N N    . LEU A 1 268 ? -17.42413 -4.90041  32.98016  1.000 38.90966  ? 268 LEU A N    1 
ATOM   3989 C CA   . LEU A 1 268 ? -17.43667 -5.14251  31.53925  1.000 44.37768  ? 268 LEU A CA   1 
ATOM   3990 C C    . LEU A 1 268 ? -17.87567 -3.88562  30.78730  1.000 40.24376  ? 268 LEU A C    1 
ATOM   3991 O O    . LEU A 1 268 ? -17.21592 -3.45562  29.83058  1.000 40.72672  ? 268 LEU A O    1 
ATOM   3992 C CB   . LEU A 1 268 ? -18.32751 -6.34054  31.21198  1.000 37.49526  ? 268 LEU A CB   1 
ATOM   3993 C CG   . LEU A 1 268 ? -18.49091 -6.78378  29.76435  1.000 40.57252  ? 268 LEU A CG   1 
ATOM   3994 C CD1  . LEU A 1 268 ? -17.16399 -6.81452  29.03091  1.000 45.45593  ? 268 LEU A CD1  1 
ATOM   3995 C CD2  . LEU A 1 268 ? -19.13721 -8.17550  29.74169  1.000 40.88727  ? 268 LEU A CD2  1 
ATOM   3996 H H    . LEU A 1 268 ? -17.91763 -5.43275  33.44131  1.000 46.74570  ? 268 LEU A H    1 
ATOM   3997 H HA   . LEU A 1 268 ? -16.54100 -5.36691  31.24205  1.000 53.30732  ? 268 LEU A HA   1 
ATOM   3998 H HB2  . LEU A 1 268 ? -17.97024 -7.10456  31.69108  1.000 45.04842  ? 268 LEU A HB2  1 
ATOM   3999 H HB3  . LEU A 1 268 ? -19.21854 -6.13363  31.53470  1.000 45.04842  ? 268 LEU A HB3  1 
ATOM   4000 H HG   . LEU A 1 268 ? -19.05637 -6.14709  29.29983  1.000 48.74112  ? 268 LEU A HG   1 
ATOM   4001 H HD11 . LEU A 1 268 ? -17.30112 -7.18611  28.14547  1.000 54.60122  ? 268 LEU A HD11 1 
ATOM   4002 H HD12 . LEU A 1 268 ? -16.82103 -5.90991  28.96053  1.000 54.60122  ? 268 LEU A HD12 1 
ATOM   4003 H HD13 . LEU A 1 268 ? -16.54083 -7.36675  29.52852  1.000 54.60122  ? 268 LEU A HD13 1 
ATOM   4004 H HD21 . LEU A 1 268 ? -19.37513 -8.39837  28.82811  1.000 49.11882  ? 268 LEU A HD21 1 
ATOM   4005 H HD22 . LEU A 1 268 ? -18.50310 -8.82382  30.08591  1.000 49.11882  ? 268 LEU A HD22 1 
ATOM   4006 H HD23 . LEU A 1 268 ? -19.93240 -8.16350  30.29705  1.000 49.11882  ? 268 LEU A HD23 1 
ATOM   4007 N N    . LYS A 1 269 ? -18.96519 -3.25474  31.23820  1.000 44.54442  ? 269 LYS A N    1 
ATOM   4008 C CA   . LYS A 1 269 ? -19.44491 -2.01655  30.61389  1.000 49.32650  ? 269 LYS A CA   1 
ATOM   4009 C C    . LYS A 1 269 ? -18.33194 -0.97296  30.47995  1.000 40.69349  ? 269 LYS A C    1 
ATOM   4010 O O    . LYS A 1 269 ? -18.15693 -0.35105  29.41611  1.000 44.63020  ? 269 LYS A O    1 
ATOM   4011 C CB   . LYS A 1 269 ? -20.61972 -1.48269  31.44073  1.000 49.35150  ? 269 LYS A CB   1 
ATOM   4012 C CG   . LYS A 1 269 ? -21.26715 -0.17631  30.97749  1.000 62.25787  ? 269 LYS A CG   1 
ATOM   4013 C CD   . LYS A 1 269 ? -22.50724 0.10729   31.85424  1.000 61.06779  ? 269 LYS A CD   1 
ATOM   4014 C CE   . LYS A 1 269 ? -23.15140 1.45894   31.58336  1.000 76.11677  ? 269 LYS A CE   1 
ATOM   4015 N NZ   . LYS A 1 269 ? -24.41972 1.59589   32.38554  1.000 78.76688  ? 269 LYS A NZ   1 
ATOM   4016 H H    . LYS A 1 269 ? -19.44340 -3.52106  31.90153  1.000 53.50740  ? 269 LYS A H    1 
ATOM   4017 H HA   . LYS A 1 269 ? -19.75335 -2.20344  29.71342  1.000 59.24590  ? 269 LYS A HA   1 
ATOM   4018 H HB2  . LYS A 1 269 ? -21.31644 -2.15758  31.43891  1.000 59.27590  ? 269 LYS A HB2  1 
ATOM   4019 H HB3  . LYS A 1 269 ? -20.30400 -1.33424  32.34582  1.000 59.27590  ? 269 LYS A HB3  1 
ATOM   4020 H HG2  . LYS A 1 269 ? -20.63889 0.55653   31.07302  1.000 74.76355  ? 269 LYS A HG2  1 
ATOM   4021 H HG3  . LYS A 1 269 ? -21.54646 -0.25533  30.05194  1.000 74.76355  ? 269 LYS A HG3  1 
ATOM   4022 H HD2  . LYS A 1 269 ? -23.17352 -0.57694  31.68455  1.000 73.33544  ? 269 LYS A HD2  1 
ATOM   4023 H HD3  . LYS A 1 269 ? -22.24198 0.08796   32.78707  1.000 73.33544  ? 269 LYS A HD3  1 
ATOM   4024 H HE2  . LYS A 1 269 ? -22.54226 2.16865   31.84058  1.000 91.39423  ? 269 LYS A HE2  1 
ATOM   4025 H HE3  . LYS A 1 269 ? -23.36938 1.53408   30.64116  1.000 91.39423  ? 269 LYS A HE3  1 
ATOM   4026 H HZ1  . LYS A 1 269 ? -24.85772 2.33053   32.13944  1.000 94.57436  ? 269 LYS A HZ1  1 
ATOM   4027 H HZ2  . LYS A 1 269 ? -24.94306 0.88876   32.25064  1.000 94.57436  ? 269 LYS A HZ2  1 
ATOM   4028 H HZ3  . LYS A 1 269 ? -24.22698 1.65136   33.25264  1.000 94.57436  ? 269 LYS A HZ3  1 
ATOM   4029 N N    . GLU A 1 270 ? -17.56695 -0.76229  31.54728  1.000 40.16513  ? 270 GLU A N    1 
ATOM   4030 C CA   . GLU A 1 270 ? -16.50909 0.24405   31.48791  1.000 47.19068  ? 270 GLU A CA   1 
ATOM   4031 C C    . GLU A 1 270 ? -15.40623 -0.19204  30.52778  1.000 46.43918  ? 270 GLU A C    1 
ATOM   4032 O O    . GLU A 1 270 ? -14.84140 0.62722   29.79460  1.000 41.02691  ? 270 GLU A O    1 
ATOM   4033 C CB   . GLU A 1 270 ? -15.96711 0.49940   32.89184  1.000 47.91112  ? 270 GLU A CB   1 
ATOM   4034 C CG   . GLU A 1 270 ? -16.95511 1.24737   33.82353  1.000 56.11157  ? 270 GLU A CG   1 
ATOM   4035 C CD   . GLU A 1 270 ? -17.45062 2.58266   33.22904  1.000 62.34279  ? 270 GLU A CD   1 
ATOM   4036 O OE1  . GLU A 1 270 ? -16.60892 3.41921   32.81974  1.000 62.22715  ? 270 GLU A OE1  1 
ATOM   4037 O OE2  . GLU A 1 270 ? -18.68477 2.78375   33.15407  1.000 63.23165  ? 270 GLU A OE2  1 
ATOM   4038 H H    . GLU A 1 270 ? -17.63629 -1.17607  32.29800  1.000 48.25225  ? 270 GLU A H    1 
ATOM   4039 H HA   . GLU A 1 270 ? -16.86801 1.08307   31.15910  1.000 56.68291  ? 270 GLU A HA   1 
ATOM   4040 H HB2  . GLU A 1 270 ? -15.76030 -0.35350  33.30499  1.000 57.54744  ? 270 GLU A HB2  1 
ATOM   4041 H HB3  . GLU A 1 270 ? -15.16316 1.03755   32.82146  1.000 57.54744  ? 270 GLU A HB3  1 
ATOM   4042 H HG2  . GLU A 1 270 ? -17.72919 0.68401   33.97947  1.000 67.38798  ? 270 GLU A HG2  1 
ATOM   4043 H HG3  . GLU A 1 270 ? -16.51087 1.44080   34.66385  1.000 67.38798  ? 270 GLU A HG3  1 
ATOM   4044 N N    . LEU A 1 271 ? -15.09913 -1.48916  30.49789  1.000 41.29725  ? 271 LEU A N    1 
ATOM   4045 C CA   . LEU A 1 271 ? -14.16157 -1.99395  29.50311  1.000 39.90992  ? 271 LEU A CA   1 
ATOM   4046 C C    . LEU A 1 271 ? -14.68277 -1.76773  28.08796  1.000 41.27714  ? 271 LEU A C    1 
ATOM   4047 O O    . LEU A 1 271 ? -13.92023 -1.38918  27.19189  1.000 43.50220  ? 271 LEU A O    1 
ATOM   4048 C CB   . LEU A 1 271 ? -13.90511 -3.48199  29.75992  1.000 37.77486  ? 271 LEU A CB   1 
ATOM   4049 C CG   . LEU A 1 271 ? -13.08077 -3.77318  31.00779  1.000 34.94820  ? 271 LEU A CG   1 
ATOM   4050 C CD1  . LEU A 1 271 ? -13.05225 -5.28132  31.27644  1.000 43.02525  ? 271 LEU A CD1  1 
ATOM   4051 C CD2  . LEU A 1 271 ? -11.67438 -3.23747  30.90945  1.000 45.84996  ? 271 LEU A CD2  1 
ATOM   4052 H H    . LEU A 1 271 ? -15.41439 -2.08452  31.03246  1.000 49.61080  ? 271 LEU A H    1 
ATOM   4053 H HA   . LEU A 1 271 ? -13.31901 -1.52007  29.58327  1.000 47.94600  ? 271 LEU A HA   1 
ATOM   4054 H HB2  . LEU A 1 271 ? -14.75978 -3.92939  29.86123  1.000 45.38393  ? 271 LEU A HB2  1 
ATOM   4055 H HB3  . LEU A 1 271 ? -13.42692 -3.84836  28.99965  1.000 45.38393  ? 271 LEU A HB3  1 
ATOM   4056 H HG   . LEU A 1 271 ? -13.50194 -3.31922  31.75441  1.000 41.99194  ? 271 LEU A HG   1 
ATOM   4057 H HD11 . LEU A 1 271 ? -12.54987 -5.44785  32.08932  1.000 51.68440  ? 271 LEU A HD11 1 
ATOM   4058 H HD12 . LEU A 1 271 ? -13.96229 -5.60115  31.37863  1.000 51.68440  ? 271 LEU A HD12 1 
ATOM   4059 H HD13 . LEU A 1 271 ? -12.62696 -5.72752  30.52748  1.000 51.68440  ? 271 LEU A HD13 1 
ATOM   4060 H HD21 . LEU A 1 271 ? -11.13424 -3.63812  31.60847  1.000 55.07405  ? 271 LEU A HD21 1 
ATOM   4061 H HD22 . LEU A 1 271 ? -11.31032 -3.46391  30.03935  1.000 55.07405  ? 271 LEU A HD22 1 
ATOM   4062 H HD23 . LEU A 1 271 ? -11.69513 -2.27388  31.01876  1.000 55.07405  ? 271 LEU A HD23 1 
ATOM   4063 N N    . LEU A 1 272 ? -15.98406 -1.98260  27.86637  1.000 39.48572  ? 272 LEU A N    1 
ATOM   4064 C CA   . LEU A 1 272 ? -16.53147 -1.82251  26.52556  1.000 45.99031  ? 272 LEU A CA   1 
ATOM   4065 C C    . LEU A 1 272 ? -16.52176 -0.36011  26.11448  1.000 50.01567  ? 272 LEU A C    1 
ATOM   4066 O O    . LEU A 1 272 ? -16.18512 -0.03822  24.97082  1.000 50.49079  ? 272 LEU A O    1 
ATOM   4067 C CB   . LEU A 1 272 ? -17.95544 -2.36912  26.44709  1.000 46.10508  ? 272 LEU A CB   1 
ATOM   4068 C CG   . LEU A 1 272 ? -18.05860 -3.89854  26.40224  1.000 38.49553  ? 272 LEU A CG   1 
ATOM   4069 C CD1  . LEU A 1 272 ? -19.48972 -4.39642  26.30761  1.000 39.66776  ? 272 LEU A CD1  1 
ATOM   4070 C CD2  . LEU A 1 272 ? -17.27056 -4.40639  25.21867  1.000 48.26750  ? 272 LEU A CD2  1 
ATOM   4071 H H    . LEU A 1 272 ? -16.55566 -2.21667  28.46477  1.000 47.43697  ? 272 LEU A H    1 
ATOM   4072 H HA   . LEU A 1 272 ? -15.98306 -2.33403  25.91034  1.000 55.24247  ? 272 LEU A HA   1 
ATOM   4073 H HB2  . LEU A 1 272 ? -18.44363 -2.06644  27.22873  1.000 55.38019  ? 272 LEU A HB2  1 
ATOM   4074 H HB3  . LEU A 1 272 ? -18.37219 -2.02473  25.64173  1.000 55.38019  ? 272 LEU A HB3  1 
ATOM   4075 H HG   . LEU A 1 272 ? -17.69972 -4.24765  27.23304  1.000 46.24874  ? 272 LEU A HG   1 
ATOM   4076 H HD11 . LEU A 1 272 ? -19.48890 -5.36614  26.33070  1.000 47.65542  ? 272 LEU A HD11 1 
ATOM   4077 H HD12 . LEU A 1 272 ? -19.99556 -4.04810  27.05841  1.000 47.65542  ? 272 LEU A HD12 1 
ATOM   4078 H HD13 . LEU A 1 272 ? -19.87776 -4.08571  25.47467  1.000 47.65542  ? 272 LEU A HD13 1 
ATOM   4079 H HD21 . LEU A 1 272 ? -16.32785 -4.41467  25.44701  1.000 57.97510  ? 272 LEU A HD21 1 
ATOM   4080 H HD22 . LEU A 1 272 ? -17.56681 -5.30476  25.00402  1.000 57.97510  ? 272 LEU A HD22 1 
ATOM   4081 H HD23 . LEU A 1 272 ? -17.42254 -3.81840  24.46231  1.000 57.97510  ? 272 LEU A HD23 1 
ATOM   4082 N N    . GLN A 1 273 ? -16.91369 0.53155   27.03590  1.000 46.48712  ? 273 GLN A N    1 
ATOM   4083 C CA   . GLN A 1 273 ? -16.97307 1.96241   26.75115  1.000 49.67611  ? 273 GLN A CA   1 
ATOM   4084 C C    . GLN A 1 273 ? -15.60384 2.63375   26.73364  1.000 51.76561  ? 273 GLN A C    1 
ATOM   4085 O O    . GLN A 1 273 ? -15.41430 3.62438   26.01271  1.000 52.89004  ? 273 GLN A O    1 
ATOM   4086 C CB   . GLN A 1 273 ? -17.85008 2.66749   27.79071  1.000 48.55395  ? 273 GLN A CB   1 
ATOM   4087 C CG   . GLN A 1 273 ? -19.33949 2.38258   27.67112  1.000 54.14428  ? 273 GLN A CG   1 
ATOM   4088 C CD   . GLN A 1 273 ? -20.12928 2.69950   28.94676  1.000 54.47514  ? 273 GLN A CD   1 
ATOM   4089 O OE1  . GLN A 1 273 ? -19.57768 3.15258   29.95139  1.000 57.12213  ? 273 GLN A OE1  1 
ATOM   4090 N NE2  . GLN A 1 273 ? -21.42769 2.43565   28.90819  1.000 58.59940  ? 273 GLN A NE2  1 
ATOM   4091 H H    . GLN A 1 273 ? -17.15094 0.32806   27.83709  1.000 55.83865  ? 273 GLN A H    1 
ATOM   4092 H HA   . GLN A 1 273 ? -17.36738 2.06560   25.87094  1.000 59.66543  ? 273 GLN A HA   1 
ATOM   4093 H HB2  . GLN A 1 273 ? -17.56900 2.38232   28.67421  1.000 58.31884  ? 273 GLN A HB2  1 
ATOM   4094 H HB3  . GLN A 1 273 ? -17.72828 3.62522   27.69685  1.000 58.31884  ? 273 GLN A HB3  1 
ATOM   4095 H HG2  . GLN A 1 273 ? -19.70502 2.92394   26.95403  1.000 65.02724  ? 273 GLN A HG2  1 
ATOM   4096 H HG3  . GLN A 1 273 ? -19.46301 1.44126   27.47222  1.000 65.02724  ? 273 GLN A HG3  1 
ATOM   4097 H HE21 . GLN A 1 273 ? -21.77855 2.10625   28.19545  1.000 70.37338  ? 273 GLN A HE21 1 
ATOM   4098 H HE22 . GLN A 1 273 ? -21.91925 2.59385   29.59590  1.000 70.37338  ? 273 GLN A HE22 1 
ATOM   4099 N N    . ASN A 1 274 ? -14.64466 2.14487   27.52529  1.000 49.15399  ? 274 ASN A N    1 
ATOM   4100 C CA   . ASN A 1 274 ? -13.37653 2.84662   27.70255  1.000 48.95287  ? 274 ASN A CA   1 
ATOM   4101 C C    . ASN A 1 274 ? -12.17565 2.08850   27.16514  1.000 51.21668  ? 274 ASN A C    1 
ATOM   4102 O O    . ASN A 1 274 ? -11.06720 2.63320   27.17895  1.000 49.89521  ? 274 ASN A O    1 
ATOM   4103 C CB   . ASN A 1 274 ? -13.16480 3.15024   29.19393  1.000 52.95550  ? 274 ASN A CB   1 
ATOM   4104 C CG   . ASN A 1 274 ? -14.31512 3.95226   29.77562  1.000 56.08973  ? 274 ASN A CG   1 
ATOM   4105 O OD1  . ASN A 1 274 ? -14.74504 4.93928   29.18287  1.000 59.27862  ? 274 ASN A OD1  1 
ATOM   4106 N ND2  . ASN A 1 274 ? -14.84633 3.50887   30.91316  1.000 52.52489  ? 274 ASN A ND2  1 
ATOM   4107 H H    . ASN A 1 274 ? -14.70748 1.41018   27.96788  1.000 59.03889  ? 274 ASN A H    1 
ATOM   4108 H HA   . ASN A 1 274 ? -13.41423 3.68893   27.22298  1.000 58.79754  ? 274 ASN A HA   1 
ATOM   4109 H HB2  . ASN A 1 274 ? -13.09800 2.31564   29.68371  1.000 63.60070  ? 274 ASN A HB2  1 
ATOM   4110 H HB3  . ASN A 1 274 ? -12.34986 3.66495   29.30281  1.000 63.60070  ? 274 ASN A HB3  1 
ATOM   4111 H HD21 . ASN A 1 274 ? -15.49985 3.93347   31.27678  1.000 63.08396  ? 274 ASN A HD21 1 
ATOM   4112 H HD22 . ASN A 1 274 ? -14.53592 2.79787   31.28428  1.000 63.08396  ? 274 ASN A HD22 1 
ATOM   4113 N N    . GLY A 1 275 ? -12.35854 0.86814   26.69244  1.000 48.44883  ? 275 GLY A N    1 
ATOM   4114 C CA   . GLY A 1 275 ? -11.23187 0.13289   26.18063  1.000 41.75885  ? 275 GLY A CA   1 
ATOM   4115 C C    . GLY A 1 275 ? -10.34104 -0.33795  27.31659  1.000 48.09295  ? 275 GLY A C    1 
ATOM   4116 O O    . GLY A 1 275 ? -10.64246 -0.17736  28.49965  1.000 44.96649  ? 275 GLY A O    1 
ATOM   4117 H H    . GLY A 1 275 ? -13.11250 0.45574   26.65972  1.000 58.19270  ? 275 GLY A H    1 
ATOM   4118 H HA2  . GLY A 1 275 ? -11.54280 -0.64077  25.68497  1.000 50.16473  ? 275 GLY A HA2  1 
ATOM   4119 H HA3  . GLY A 1 275 ? -10.71209 0.69906   25.58887  1.000 50.16473  ? 275 GLY A HA3  1 
ATOM   4120 N N    . MET A 1 276 ? -9.21139  -0.92087  26.92883  1.000 43.92431  ? 276 MET A N    1 
ATOM   4121 C CA   . MET A 1 276 ? -8.28407  -1.53071  27.87233  1.000 46.04183  ? 276 MET A CA   1 
ATOM   4122 C C    . MET A 1 276 ? -7.09140  -0.64178  28.21084  1.000 54.02965  ? 276 MET A C    1 
ATOM   4123 O O    . MET A 1 276 ? -6.28055  -1.01011  29.06717  1.000 47.44319  ? 276 MET A O    1 
ATOM   4124 C CB   . MET A 1 276 ? -7.78157  -2.87158  27.32761  1.000 53.66904  ? 276 MET A CB   1 
ATOM   4125 C CG   . MET A 1 276 ? -8.81121  -4.00502  27.39922  1.000 51.57229  ? 276 MET A CG   1 
ATOM   4126 S SD   . MET A 1 276 ? -8.00460  -5.61624  27.49603  1.000 62.39754  ? 276 MET A SD   1 
ATOM   4127 C CE   . MET A 1 276 ? -9.41291  -6.63046  27.92043  1.000 62.56328  ? 276 MET A CE   1 
ATOM   4128 H H    . MET A 1 276 ? -8.95640  -0.97627  26.10937  1.000 52.76327  ? 276 MET A H    1 
ATOM   4129 H HA   . MET A 1 276 ? -8.77087  -1.70674  28.69266  1.000 55.30430  ? 276 MET A HA   1 
ATOM   4130 H HB2  . MET A 1 276 ? -7.53614  -2.75550  26.39637  1.000 64.45695  ? 276 MET A HB2  1 
ATOM   4131 H HB3  . MET A 1 276 ? -7.00681  -3.14493  27.84329  1.000 64.45695  ? 276 MET A HB3  1 
ATOM   4132 H HG2  . MET A 1 276 ? -9.36186  -3.89015  28.18946  1.000 61.94084  ? 276 MET A HG2  1 
ATOM   4133 H HG3  . MET A 1 276 ? -9.36535  -3.98720  26.60328  1.000 61.94084  ? 276 MET A HG3  1 
ATOM   4134 H HE1  . MET A 1 276 ? -9.88715  -6.21889  28.65976  1.000 75.13004  ? 276 MET A HE1  1 
ATOM   4135 H HE2  . MET A 1 276 ? -9.99731  -6.69802  27.14919  1.000 75.13004  ? 276 MET A HE2  1 
ATOM   4136 H HE3  . MET A 1 276 ? -9.10105  -7.51229  28.17739  1.000 75.13004  ? 276 MET A HE3  1 
ATOM   4137 N N    . ASN A 1 277 ? -6.95792  0.51384   27.57056  1.000 49.55691  ? 277 ASN A N    1 
ATOM   4138 C CA   . ASN A 1 277 ? -5.88826  1.44713   27.91255  1.000 51.90631  ? 277 ASN A CA   1 
ATOM   4139 C C    . ASN A 1 277 ? -4.51502  0.80599   27.77915  1.000 48.32604  ? 277 ASN A C    1 
ATOM   4140 O O    . ASN A 1 277 ? -3.59518  1.12124   28.53646  1.000 50.10862  ? 277 ASN A O    1 
ATOM   4141 C CB   . ASN A 1 277 ? -6.07530  1.98210   29.33286  1.000 54.80203  ? 277 ASN A CB   1 
ATOM   4142 C CG   . ASN A 1 277 ? -7.03265  3.12455   29.39071  1.000 58.07997  ? 277 ASN A CG   1 
ATOM   4143 O OD1  . ASN A 1 277 ? -6.65108  4.26907   29.16733  1.000 78.39112  ? 277 ASN A OD1  1 
ATOM   4144 N ND2  . ASN A 1 277 ? -8.29287  2.83183   29.68196  1.000 70.95131  ? 277 ASN A ND2  1 
ATOM   4145 H H    . ASN A 1 277 ? -7.47281  0.78047   26.93543  1.000 59.52239  ? 277 ASN A H    1 
ATOM   4146 H HA   . ASN A 1 277 ? -5.92352  2.19109   27.29111  1.000 62.34167  ? 277 ASN A HA   1 
ATOM   4147 H HB2  . ASN A 1 277 ? -6.41977  1.27179   29.89650  1.000 65.81654  ? 277 ASN A HB2  1 
ATOM   4148 H HB3  . ASN A 1 277 ? -5.21964  2.28887   29.67145  1.000 65.81654  ? 277 ASN A HB3  1 
ATOM   4149 H HD21 . ASN A 1 277 ? -8.88056  3.45812   29.72645  1.000 85.19567  ? 277 ASN A HD21 1 
ATOM   4150 H HD22 . ASN A 1 277 ? -8.52243  2.01571   29.82635  1.000 85.19567  ? 277 ASN A HD22 1 
ATOM   4151 N N    . GLY A 1 278 ? -4.36291  -0.11246  26.82701  1.000 46.52295  ? 278 GLY A N    1 
ATOM   4152 C CA   . GLY A 1 278 ? -3.08281  -0.74994  26.59905  1.000 53.40920  ? 278 GLY A CA   1 
ATOM   4153 C C    . GLY A 1 278 ? -2.69449  -1.79400  27.61930  1.000 49.74197  ? 278 GLY A C    1 
ATOM   4154 O O    . GLY A 1 278 ? -1.54479  -2.25300  27.61082  1.000 46.79843  ? 278 GLY A O    1 
ATOM   4155 H H    . GLY A 1 278 ? -4.98999  -0.37963  26.30262  1.000 55.88164  ? 278 GLY A H    1 
ATOM   4156 H HA2  . GLY A 1 278 ? -3.10192  -1.18021  25.72992  1.000 64.14514  ? 278 GLY A HA2  1 
ATOM   4157 H HA3  . GLY A 1 278 ? -2.39323  -0.06775  26.59861  1.000 64.14514  ? 278 GLY A HA3  1 
ATOM   4158 N N    . ARG A 1 279 ? -3.60781  -2.16037  28.51542  1.000 46.38174  ? 279 ARG A N    1 
ATOM   4159 C CA   . ARG A 1 279 ? -3.36488  -3.20262  29.48982  1.000 44.01168  ? 279 ARG A CA   1 
ATOM   4160 C C    . ARG A 1 279 ? -3.81769  -4.54222  28.91775  1.000 42.14828  ? 279 ARG A C    1 
ATOM   4161 O O    . ARG A 1 279 ? -4.40225  -4.62515  27.82538  1.000 40.17392  ? 279 ARG A O    1 
ATOM   4162 C CB   . ARG A 1 279 ? -4.08954  -2.90637  30.79330  1.000 40.57734  ? 279 ARG A CB   1 
ATOM   4163 H H    . ARG A 1 279 ? -4.39044  -1.80892  28.57528  1.000 55.71218  ? 279 ARG A H    1 
ATOM   4164 H HA   . ARG A 1 279 ? -2.41392  -3.23641  29.67806  1.000 52.86812  ? 279 ARG A HA   1 
ATOM   4165 N N    . THR A 1 280 ? -3.56354  -5.59967  29.67205  1.000 40.80401  ? 280 THR A N    1 
ATOM   4166 C CA   . THR A 1 280 ? -3.96171  -6.94714  29.30200  1.000 35.99667  ? 280 THR A CA   1 
ATOM   4167 C C    . THR A 1 280 ? -4.68545  -7.61804  30.45686  1.000 40.37705  ? 280 THR A C    1 
ATOM   4168 O O    . THR A 1 280 ? -4.58156  -7.21891  31.62448  1.000 40.30292  ? 280 THR A O    1 
ATOM   4169 C CB   . THR A 1 280 ? -2.74209  -7.77493  28.86905  1.000 40.56231  ? 280 THR A CB   1 
ATOM   4170 O OG1  . THR A 1 280 ? -1.88962  -7.99864  29.99394  1.000 41.79528  ? 280 THR A OG1  1 
ATOM   4171 C CG2  . THR A 1 280 ? -1.99763  -7.03586  27.78714  1.000 48.10946  ? 280 THR A CG2  1 
ATOM   4172 H H    . THR A 1 280 ? -3.14957  -5.56094  30.42486  1.000 49.01891  ? 280 THR A H    1 
ATOM   4173 H HA   . THR A 1 280 ? -4.58760  -6.91125  28.56181  1.000 43.25010  ? 280 THR A HA   1 
ATOM   4174 H HB   . THR A 1 280 ? -3.02037  -8.63628  28.52044  1.000 48.72888  ? 280 THR A HB   1 
ATOM   4175 H HG1  . THR A 1 280 ? -1.90560  -7.33123  30.50375  1.000 50.20844  ? 280 THR A HG1  1 
ATOM   4176 H HG21 . THR A 1 280 ? -1.58766  -6.23657  28.15315  1.000 57.78546  ? 280 THR A HG21 1 
ATOM   4177 H HG22 . THR A 1 280 ? -1.30437  -7.60293  27.41469  1.000 57.78546  ? 280 THR A HG22 1 
ATOM   4178 H HG23 . THR A 1 280 ? -2.60919  -6.77996  27.07904  1.000 57.78546  ? 280 THR A HG23 1 
ATOM   4179 N N    . ILE A 1 281 ? -5.47105  -8.62636  30.08452  1.000 34.38201  ? 281 ILE A N    1 
ATOM   4180 C CA   . ILE A 1 281 ? -6.21090  -9.48889  30.98245  1.000 33.14593  ? 281 ILE A CA   1 
ATOM   4181 C C    . ILE A 1 281 ? -5.89182  -10.90818 30.54988  1.000 40.45480  ? 281 ILE A C    1 
ATOM   4182 O O    . ILE A 1 281 ? -6.09800  -11.25524 29.38102  1.000 37.49629  ? 281 ILE A O    1 
ATOM   4183 C CB   . ILE A 1 281 ? -7.72351  -9.21736  30.91816  1.000 39.20199  ? 281 ILE A CB   1 
ATOM   4184 C CG1  . ILE A 1 281 ? -7.98222  -7.73376  31.23383  1.000 43.08316  ? 281 ILE A CG1  1 
ATOM   4185 C CG2  . ILE A 1 281 ? -8.46814  -10.13625 31.83023  1.000 37.86531  ? 281 ILE A CG2  1 
ATOM   4186 C CD1  . ILE A 1 281 ? -9.43477  -7.36138  31.37320  1.000 42.55419  ? 281 ILE A CD1  1 
ATOM   4187 H H    . ILE A 1 281 ? -5.59528  -8.83917  29.26058  1.000 41.31251  ? 281 ILE A H    1 
ATOM   4188 H HA   . ILE A 1 281 ? -5.92922  -9.35987  31.90165  1.000 39.82922  ? 281 ILE A HA   1 
ATOM   4189 H HB   . ILE A 1 281 ? -8.05077  -9.39689  30.02285  1.000 47.09649  ? 281 ILE A HB   1 
ATOM   4190 H HG12 . ILE A 1 281 ? -7.54382  -7.51627  32.07132  1.000 51.75390  ? 281 ILE A HG12 1 
ATOM   4191 H HG13 . ILE A 1 281 ? -7.61123  -7.19710  30.51601  1.000 51.75390  ? 281 ILE A HG13 1 
ATOM   4192 H HG21 . ILE A 1 281 ? -9.32491  -10.35243 31.43009  1.000 45.49247  ? 281 ILE A HG21 1 
ATOM   4193 H HG22 . ILE A 1 281 ? -7.94839  -10.94548 31.95642  1.000 45.49247  ? 281 ILE A HG22 1 
ATOM   4194 H HG23 . ILE A 1 281 ? -8.60344  -9.69373  32.68273  1.000 45.49247  ? 281 ILE A HG23 1 
ATOM   4195 H HD11 . ILE A 1 281 ? -9.50557  -6.39967  31.47811  1.000 51.11913  ? 281 ILE A HD11 1 
ATOM   4196 H HD12 . ILE A 1 281 ? -9.91088  -7.64314  30.57644  1.000 51.11913  ? 281 ILE A HD12 1 
ATOM   4197 H HD13 . ILE A 1 281 ? -9.80164  -7.80705  32.15274  1.000 51.11913  ? 281 ILE A HD13 1 
ATOM   4198 N N    . LEU A 1 282 ? -5.36142  -11.70250 31.47221  1.000 36.93085  ? 282 LEU A N    1 
ATOM   4199 C CA   . LEU A 1 282 ? -4.95460  -13.07660 31.19642  1.000 37.36721  ? 282 LEU A CA   1 
ATOM   4200 C C    . LEU A 1 282 ? -4.15308  -13.15413 29.90100  1.000 31.13959  ? 282 LEU A C    1 
ATOM   4201 O O    . LEU A 1 282 ? -4.35915  -14.02582 29.05013  1.000 40.03057  ? 282 LEU A O    1 
ATOM   4202 C CB   . LEU A 1 282 ? -6.16500  -14.00198 31.14381  1.000 38.39170  ? 282 LEU A CB   1 
ATOM   4203 C CG   . LEU A 1 282 ? -6.79085  -14.32879 32.49489  1.000 37.77667  ? 282 LEU A CG   1 
ATOM   4204 C CD1  . LEU A 1 282 ? -7.99898  -15.22313 32.28009  1.000 38.65243  ? 282 LEU A CD1  1 
ATOM   4205 C CD2  . LEU A 1 282 ? -5.77942  -15.01521 33.40720  1.000 44.70467  ? 282 LEU A CD2  1 
ATOM   4206 H H    . LEU A 1 282 ? -5.22311  -11.46323 32.28660  1.000 44.37113  ? 282 LEU A H    1 
ATOM   4207 H HA   . LEU A 1 282 ? -4.38004  -13.37666 31.91804  1.000 44.89476  ? 282 LEU A HA   1 
ATOM   4208 H HB2  . LEU A 1 282 ? -6.84912  -13.57976 30.60104  1.000 46.12414  ? 282 LEU A HB2  1 
ATOM   4209 H HB3  . LEU A 1 282 ? -5.89142  -14.84031 30.73976  1.000 46.12414  ? 282 LEU A HB3  1 
ATOM   4210 H HG   . LEU A 1 282 ? -7.07191  -13.50962 32.93178  1.000 45.38611  ? 282 LEU A HG   1 
ATOM   4211 H HD11 . LEU A 1 282 ? -8.49048  -15.29543 33.11321  1.000 46.43701  ? 282 LEU A HD11 1 
ATOM   4212 H HD12 . LEU A 1 282 ? -8.56395  -14.83170 31.59563  1.000 46.43701  ? 282 LEU A HD12 1 
ATOM   4213 H HD13 . LEU A 1 282 ? -7.69630  -16.10027 31.99741  1.000 46.43701  ? 282 LEU A HD13 1 
ATOM   4214 H HD21 . LEU A 1 282 ? -5.28858  -14.33896 33.89982  1.000 53.69970  ? 282 LEU A HD21 1 
ATOM   4215 H HD22 . LEU A 1 282 ? -6.25301  -15.59515 34.02388  1.000 53.69970  ? 282 LEU A HD22 1 
ATOM   4216 H HD23 . LEU A 1 282 ? -5.16845  -15.53786 32.86458  1.000 53.69970  ? 282 LEU A HD23 1 
ATOM   4217 N N    . GLY A 1 283 ? -3.22269  -12.21974 29.74845  1.000 34.19641  ? 283 GLY A N    1 
ATOM   4218 C CA   . GLY A 1 283 ? -2.34923  -12.23521 28.59644  1.000 37.49478  ? 283 GLY A CA   1 
ATOM   4219 C C    . GLY A 1 283 ? -2.95834  -11.77618 27.29801  1.000 40.13452  ? 283 GLY A C    1 
ATOM   4220 O O    . GLY A 1 283 ? -2.32655  -11.93253 26.24837  1.000 40.90055  ? 283 GLY A O    1 
ATOM   4221 H H    . GLY A 1 283 ? -3.08194  -11.57254 30.29701  1.000 41.08979  ? 283 GLY A H    1 
ATOM   4222 H HA2  . GLY A 1 283 ? -1.59005  -11.66021 28.78061  1.000 45.04783  ? 283 GLY A HA2  1 
ATOM   4223 H HA3  . GLY A 1 283 ? -2.03332  -13.14278 28.46443  1.000 45.04783  ? 283 GLY A HA3  1 
ATOM   4224 N N    . SER A 1 284 ? -4.18328  -11.23521 27.31435  1.000 40.28444  ? 284 SER A N    1 
ATOM   4225 C CA   . SER A 1 284 ? -4.86846  -10.80858 26.10669  1.000 37.29071  ? 284 SER A CA   1 
ATOM   4226 C C    . SER A 1 284 ? -5.17095  -9.31394  26.15633  1.000 36.79290  ? 284 SER A C    1 
ATOM   4227 O O    . SER A 1 284 ? -5.45596  -8.75338  27.21798  1.000 36.83589  ? 284 SER A O    1 
ATOM   4228 C CB   . SER A 1 284 ? -6.18256  -11.59971 25.92085  1.000 33.56316  ? 284 SER A CB   1 
ATOM   4229 O OG   . SER A 1 284 ? -6.92890  -11.12359 24.81640  1.000 38.28857  ? 284 SER A OG   1 
ATOM   4230 H H    . SER A 1 284 ? -4.63968  -11.10615 28.03173  1.000 48.39543  ? 284 SER A H    1 
ATOM   4231 H HA   . SER A 1 284 ? -4.29474  -10.96314 25.33997  1.000 44.80295  ? 284 SER A HA   1 
ATOM   4232 H HB2  . SER A 1 284 ? -5.96646  -12.53361 25.77240  1.000 40.32989  ? 284 SER A HB2  1 
ATOM   4233 H HB3  . SER A 1 284 ? -6.71909  -11.50689 26.72361  1.000 40.32989  ? 284 SER A HB3  1 
ATOM   4234 H HG   . SER A 1 284 ? -7.62686  -11.58145 24.72248  1.000 46.00039  ? 284 SER A HG   1 
ATOM   4235 N N    . ALA A 1 285 ? -5.10957  -8.67441  24.98402  1.000 36.65044  ? 285 ALA A N    1 
ATOM   4236 C CA   . ALA A 1 285 ? -5.48040  -7.26847  24.83201  1.000 39.98102  ? 285 ALA A CA   1 
ATOM   4237 C C    . ALA A 1 285 ? -6.86810  -7.07733  24.22851  1.000 39.92985  ? 285 ALA A C    1 
ATOM   4238 O O    . ALA A 1 285 ? -7.21891  -5.95704  23.82834  1.000 43.07377  ? 285 ALA A O    1 
ATOM   4239 C CB   . ALA A 1 285 ? -4.43027  -6.54909  23.99649  1.000 37.34740  ? 285 ALA A CB   1 
ATOM   4240 H H    . ALA A 1 285 ? -4.85131  -9.04244  24.25091  1.000 44.03463  ? 285 ALA A H    1 
ATOM   4241 H HA   . ALA A 1 285 ? -5.49773  -6.85632  25.70993  1.000 48.03133  ? 285 ALA A HA   1 
ATOM   4242 H HB1  . ALA A 1 285 ? -4.76478  -5.67070  23.75684  1.000 44.87098  ? 285 ALA A HB1  1 
ATOM   4243 H HB2  . ALA A 1 285 ? -3.61693  -6.46237  24.51789  1.000 44.87098  ? 285 ALA A HB2  1 
ATOM   4244 H HB3  . ALA A 1 285 ? -4.25568  -7.06658  23.19485  1.000 44.87098  ? 285 ALA A HB3  1 
ATOM   4245 N N    . LEU A 1 286 ? -7.66710  -8.13849  24.16479  1.000 36.07189  ? 286 LEU A N    1 
ATOM   4246 C CA   . LEU A 1 286 ? -9.06662  -8.05635  23.79252  1.000 36.68851  ? 286 LEU A CA   1 
ATOM   4247 C C    . LEU A 1 286 ? -9.87392  -8.86803  24.79471  1.000 35.74536  ? 286 LEU A C    1 
ATOM   4248 O O    . LEU A 1 286 ? -9.32835  -9.68001  25.54153  1.000 37.00377  ? 286 LEU A O    1 
ATOM   4249 C CB   . LEU A 1 286 ? -9.33540  -8.62383  22.41226  1.000 37.94506  ? 286 LEU A CB   1 
ATOM   4250 C CG   . LEU A 1 286 ? -8.39636  -8.24482  21.29249  1.000 46.48646  ? 286 LEU A CG   1 
ATOM   4251 C CD1  . LEU A 1 286 ? -8.55815  -9.29567  20.24729  1.000 37.37727  ? 286 LEU A CD1  1 
ATOM   4252 C CD2  . LEU A 1 286 ? -8.71443  -6.86862  20.76395  1.000 45.10491  ? 286 LEU A CD2  1 
ATOM   4253 H H    . LEU A 1 286 ? -7.40879  -8.94004  24.33911  1.000 43.34037  ? 286 LEU A H    1 
ATOM   4254 H HA   . LEU A 1 286 ? -9.33194  -7.12340  23.80324  1.000 44.08031  ? 286 LEU A HA   1 
ATOM   4255 H HB2  . LEU A 1 286 ? -9.30938  -9.59099  22.48170  1.000 45.58817  ? 286 LEU A HB2  1 
ATOM   4256 H HB3  . LEU A 1 286 ? -10.22102 -8.33429  22.14254  1.000 45.58817  ? 286 LEU A HB3  1 
ATOM   4257 H HG   . LEU A 1 286 ? -7.47320  -8.20012  21.58690  1.000 55.83785  ? 286 LEU A HG   1 
ATOM   4258 H HD11 . LEU A 1 286 ? -7.93419  -9.12166  19.52528  1.000 44.90682  ? 286 LEU A HD11 1 
ATOM   4259 H HD12 . LEU A 1 286 ? -8.37519  -10.16321 20.64072  1.000 44.90682  ? 286 LEU A HD12 1 
ATOM   4260 H HD13 . LEU A 1 286 ? -9.46788  -9.26988  19.91170  1.000 44.90682  ? 286 LEU A HD13 1 
ATOM   4261 H HD21 . LEU A 1 286 ? -8.29961  -6.76088  19.89377  1.000 54.17999  ? 286 LEU A HD21 1 
ATOM   4262 H HD22 . LEU A 1 286 ? -9.67672  -6.77507  20.68553  1.000 54.17999  ? 286 LEU A HD22 1 
ATOM   4263 H HD23 . LEU A 1 286 ? -8.36677  -6.20540  21.38052  1.000 54.17999  ? 286 LEU A HD23 1 
ATOM   4264 N N    . LEU A 1 287 ? -11.18129 -8.65438  24.78954  1.000 31.51584  ? 287 LEU A N    1 
ATOM   4265 C CA   . LEU A 1 287 ? -12.09874 -9.45782  25.59103  1.000 34.24908  ? 287 LEU A CA   1 
ATOM   4266 C C    . LEU A 1 287 ? -12.35499 -10.79998 24.92654  1.000 34.85699  ? 287 LEU A C    1 
ATOM   4267 O O    . LEU A 1 287 ? -12.82479 -10.85905 23.78891  1.000 37.55672  ? 287 LEU A O    1 
ATOM   4268 C CB   . LEU A 1 287 ? -13.39784 -8.68347  25.76212  1.000 35.07761  ? 287 LEU A CB   1 
ATOM   4269 C CG   . LEU A 1 287 ? -13.14629 -7.28213  26.33825  1.000 40.17687  ? 287 LEU A CG   1 
ATOM   4270 C CD1  . LEU A 1 287 ? -14.37640 -6.41796  26.23481  1.000 41.33915  ? 287 LEU A CD1  1 
ATOM   4271 C CD2  . LEU A 1 287 ? -12.67519 -7.38173  27.78346  1.000 40.78133  ? 287 LEU A CD2  1 
ATOM   4272 H H    . LEU A 1 287 ? -11.56925 -8.04313  24.32536  1.000 37.87310  ? 287 LEU A H    1 
ATOM   4273 H HA   . LEU A 1 287 ? -11.70693 -9.63967  26.45954  1.000 41.15299  ? 287 LEU A HA   1 
ATOM   4274 H HB2  . LEU A 1 287 ? -13.82869 -8.58674  24.89846  1.000 42.14724  ? 287 LEU A HB2  1 
ATOM   4275 H HB3  . LEU A 1 287 ? -13.97947 -9.16505  26.37095  1.000 42.14724  ? 287 LEU A HB3  1 
ATOM   4276 H HG   . LEU A 1 287 ? -12.44870 -6.85314  25.81841  1.000 48.26634  ? 287 LEU A HG   1 
ATOM   4277 H HD11 . LEU A 1 287 ? -14.33383 -5.72556  26.91280  1.000 49.66108  ? 287 LEU A HD11 1 
ATOM   4278 H HD12 . LEU A 1 287 ? -14.40649 -6.01572  25.35266  1.000 49.66108  ? 287 LEU A HD12 1 
ATOM   4279 H HD13 . LEU A 1 287 ? -15.16226 -6.96928  26.37395  1.000 49.66108  ? 287 LEU A HD13 1 
ATOM   4280 H HD21 . LEU A 1 287 ? -12.62165 -6.48955  28.16036  1.000 48.99170  ? 287 LEU A HD21 1 
ATOM   4281 H HD22 . LEU A 1 287 ? -13.30985 -7.91574  28.28641  1.000 48.99170  ? 287 LEU A HD22 1 
ATOM   4282 H HD23 . LEU A 1 287 ? -11.80110 -7.80184  27.80245  1.000 48.99170  ? 287 LEU A HD23 1 
ATOM   4283 N N    . GLU A 1 288 ? -12.06812 -11.87036 25.64657  1.000 32.64502  ? 288 GLU A N    1 
ATOM   4284 C CA   A GLU A 1 288 ? -12.16853 -13.22965 25.13545  0.456 32.18790  ? 288 GLU A CA   1 
ATOM   4285 C CA   B GLU A 1 288 ? -12.16905 -13.22248 25.12487  0.544 32.16499  ? 288 GLU A CA   1 
ATOM   4286 C C    . GLU A 1 288 ? -13.52884 -13.83653 25.45190  1.000 28.69453  ? 288 GLU A C    1 
ATOM   4287 O O    . GLU A 1 288 ? -13.98550 -13.80408 26.59831  1.000 31.74764  ? 288 GLU A O    1 
ATOM   4288 C CB   A GLU A 1 288 ? -11.06269 -14.09107 25.75483  0.456 33.12132  ? 288 GLU A CB   1 
ATOM   4289 C CB   B GLU A 1 288 ? -11.02537 -14.06624 25.69591  0.544 33.07749  ? 288 GLU A CB   1 
ATOM   4290 C CG   A GLU A 1 288 ? -11.11757 -15.54534 25.33763  0.456 36.11101  ? 288 GLU A CG   1 
ATOM   4291 C CG   B GLU A 1 288 ? -9.62839  -13.51798 25.36447  0.544 29.47737  ? 288 GLU A CG   1 
ATOM   4292 C CD   A GLU A 1 288 ? -10.87157 -15.68515 23.86220  0.456 34.74543  ? 288 GLU A CD   1 
ATOM   4293 C CD   B GLU A 1 288 ? -9.26135  -13.65670 23.89604  0.544 39.20109  ? 288 GLU A CD   1 
ATOM   4294 O OE1  A GLU A 1 288 ? -9.72352  -15.41809 23.46531  0.456 35.57663  ? 288 GLU A OE1  1 
ATOM   4295 O OE1  B GLU A 1 288 ? -9.94963  -14.40768 23.17527  0.544 38.75743  ? 288 GLU A OE1  1 
ATOM   4296 O OE2  A GLU A 1 288 ? -11.82509 -16.02190 23.12012  0.456 32.35249  ? 288 GLU A OE2  1 
ATOM   4297 O OE2  B GLU A 1 288 ? -8.28169  -13.01459 23.46980  0.544 36.96211  ? 288 GLU A OE2  1 
ATOM   4298 H H    . GLU A 1 288 ? -11.80490 -11.83850 26.46468  1.000 39.22812  ? 288 GLU A H    1 
ATOM   4299 H HA   . GLU A 1 288 ? -12.07394 -13.21351 24.17021  1.000 38.65209  ? 288 GLU A HA   1 
ATOM   4300 H HB2  A GLU A 1 288 ? -10.20182 -13.73691 25.48210  0.456 39.79969  ? 288 GLU A HB2  1 
ATOM   4301 H HB2  B GLU A 1 288 ? -11.11100 -14.09515 26.66169  0.544 39.74709  ? 288 GLU A HB2  1 
ATOM   4302 H HB3  A GLU A 1 288 ? -11.14465 -14.05667 26.72074  0.456 39.79969  ? 288 GLU A HB3  1 
ATOM   4303 H HB3  B GLU A 1 288 ? -11.08636 -14.96270 25.33046  0.544 39.74709  ? 288 GLU A HB3  1 
ATOM   4304 H HG2  A GLU A 1 288 ? -10.43497 -16.04451 25.81280  0.456 43.38731  ? 288 GLU A HG2  1 
ATOM   4305 H HG2  B GLU A 1 288 ? -9.59915  -12.57522 25.59086  0.544 35.42695  ? 288 GLU A HG2  1 
ATOM   4306 H HG3  A GLU A 1 288 ? -11.99448 -15.90734 25.53980  0.456 43.38731  ? 288 GLU A HG3  1 
ATOM   4307 H HG3  B GLU A 1 288 ? -8.96885  -14.00439 25.88342  0.544 35.42695  ? 288 GLU A HG3  1 
ATOM   4308 N N    . ASP A 1 289 ? -14.17181 -14.42369 24.44208  1.000 28.97188  ? 289 ASP A N    1 
ATOM   4309 C CA   . ASP A 1 289 ? -15.50600 -14.97206 24.63140  1.000 29.00190  ? 289 ASP A CA   1 
ATOM   4310 C C    . ASP A 1 289 ? -15.65136 -16.44164 24.27442  1.000 29.32915  ? 289 ASP A C    1 
ATOM   4311 O O    . ASP A 1 289 ? -16.76972 -16.93338 24.19812  1.000 27.45251  ? 289 ASP A O    1 
ATOM   4312 C CB   . ASP A 1 289 ? -16.53522 -14.13527 23.85191  1.000 32.00485  ? 289 ASP A CB   1 
ATOM   4313 C CG   . ASP A 1 289 ? -16.63129 -14.49035 22.37586  1.000 33.04834  ? 289 ASP A CG   1 
ATOM   4314 O OD1  . ASP A 1 289 ? -15.66208 -15.02435 21.78315  1.000 32.70135  ? 289 ASP A OD1  1 
ATOM   4315 O OD2  . ASP A 1 289 ? -17.69883 -14.18437 21.78233  1.000 32.90402  ? 289 ASP A OD2  1 
ATOM   4316 H H    . ASP A 1 289 ? -13.85562 -14.51362 23.64739  1.000 34.82035  ? 289 ASP A H    1 
ATOM   4317 H HA   . ASP A 1 289 ? -15.70466 -14.91226 25.57896  1.000 34.85639  ? 289 ASP A HA   1 
ATOM   4318 H HB2  . ASP A 1 289 ? -17.41090 -14.27321 24.24569  1.000 38.45992  ? 289 ASP A HB2  1 
ATOM   4319 H HB3  . ASP A 1 289 ? -16.28706 -13.19963 23.91428  1.000 38.45992  ? 289 ASP A HB3  1 
ATOM   4320 N N    . GLU A 1 290 ? -14.55186 -17.18718 24.08325  1.000 32.09182  ? 290 GLU A N    1 
ATOM   4321 C CA   . GLU A 1 290 ? -14.66943 -18.59668 23.74957  1.000 30.48614  ? 290 GLU A CA   1 
ATOM   4322 C C    . GLU A 1 290 ? -14.35892 -19.49937 24.92492  1.000 32.05056  ? 290 GLU A C    1 
ATOM   4323 O O    . GLU A 1 290 ? -14.04171 -20.67216 24.72679  1.000 31.22296  ? 290 GLU A O    1 
ATOM   4324 C CB   . GLU A 1 290 ? -13.78188 -18.95031 22.53391  1.000 31.88161  ? 290 GLU A CB   1 
ATOM   4325 C CG   . GLU A 1 290 ? -14.23617 -18.18020 21.30303  1.000 32.49400  ? 290 GLU A CG   1 
ATOM   4326 C CD   . GLU A 1 290 ? -14.11646 -18.95835 20.01657  1.000 42.96033  ? 290 GLU A CD   1 
ATOM   4327 O OE1  . GLU A 1 290 ? -13.52752 -20.06451 20.03720  1.000 37.42165  ? 290 GLU A OE1  1 
ATOM   4328 O OE2  . GLU A 1 290 ? -14.63511 -18.47044 18.98479  1.000 37.26702  ? 290 GLU A OE2  1 
ATOM   4329 H H    . GLU A 1 290 ? -13.74529 -16.89474 24.14260  1.000 38.56428  ? 290 GLU A H    1 
ATOM   4330 H HA   . GLU A 1 290 ? -15.58920 -18.76692 23.49277  1.000 36.63747  ? 290 GLU A HA   1 
ATOM   4331 H HB2  . GLU A 1 290 ? -12.86065 -18.71426 22.72499  1.000 38.31203  ? 290 GLU A HB2  1 
ATOM   4332 H HB3  . GLU A 1 290 ? -13.84932 -19.89994 22.34806  1.000 38.31203  ? 290 GLU A HB3  1 
ATOM   4333 H HG2  . GLU A 1 290 ? -15.16831 -17.93612 21.41456  1.000 39.04690  ? 290 GLU A HG2  1 
ATOM   4334 H HG3  . GLU A 1 290 ? -13.69219 -17.38175 21.21660  1.000 39.04690  ? 290 GLU A HG3  1 
ATOM   4335 N N    . PHE A 1 291 ? -14.54239 -19.02341 26.15421  1.000 30.41775  ? 291 PHE A N    1 
ATOM   4336 C CA   . PHE A 1 291 ? -14.53222 -19.89589 27.32606  1.000 33.67475  ? 291 PHE A CA   1 
ATOM   4337 C C    . PHE A 1 291 ? -15.91155 -19.90655 27.96351  1.000 37.62197  ? 291 PHE A C    1 
ATOM   4338 O O    . PHE A 1 291 ? -16.39936 -18.84976 28.35965  1.000 32.15277  ? 291 PHE A O    1 
ATOM   4339 C CB   . PHE A 1 291 ? -13.52160 -19.42402 28.36631  1.000 34.95131  ? 291 PHE A CB   1 
ATOM   4340 C CG   . PHE A 1 291 ? -12.11482 -19.51028 27.89670  1.000 34.34008  ? 291 PHE A CG   1 
ATOM   4341 C CD1  . PHE A 1 291 ? -11.42536 -20.72430 27.97751  1.000 45.06682  ? 291 PHE A CD1  1 
ATOM   4342 C CD2  . PHE A 1 291 ? -11.48787 -18.41776 27.35034  1.000 33.63844  ? 291 PHE A CD2  1 
ATOM   4343 C CE1  . PHE A 1 291 ? -10.12243 -20.81922 27.53242  1.000 40.70575  ? 291 PHE A CE1  1 
ATOM   4344 C CE2  . PHE A 1 291 ? -10.18387 -18.50649 26.89858  1.000 47.21318  ? 291 PHE A CE2  1 
ATOM   4345 C CZ   . PHE A 1 291 ? -9.50395  -19.72822 26.99282  1.000 39.67053  ? 291 PHE A CZ   1 
ATOM   4346 H H    . PHE A 1 291 ? -14.67549 -18.19333 26.33545  1.000 36.55541  ? 291 PHE A H    1 
ATOM   4347 H HA   . PHE A 1 291 ? -14.30257 -20.79075 27.03046  1.000 40.46380  ? 291 PHE A HA   1 
ATOM   4348 H HB2  . PHE A 1 291 ? -13.70654 -18.49754 28.58616  1.000 41.99567  ? 291 PHE A HB2  1 
ATOM   4349 H HB3  . PHE A 1 291 ? -13.60593 -19.97635 29.15922  1.000 41.99567  ? 291 PHE A HB3  1 
ATOM   4350 H HD1  . PHE A 1 291 ? -11.84760 -21.47255 28.33350  1.000 54.13429  ? 291 PHE A HD1  1 
ATOM   4351 H HD2  . PHE A 1 291 ? -11.94453 -17.61037 27.28343  1.000 40.42023  ? 291 PHE A HD2  1 
ATOM   4352 H HE1  . PHE A 1 291 ? -9.66567  -21.62650 27.60007  1.000 48.90101  ? 291 PHE A HE1  1 
ATOM   4353 H HE2  . PHE A 1 291 ? -9.76173  -17.76168 26.53531  1.000 56.70992  ? 291 PHE A HE2  1 
ATOM   4354 H HZ   . PHE A 1 291 ? -8.62839  -19.79608 26.68674  1.000 47.65873  ? 291 PHE A HZ   1 
ATOM   4355 N N    . THR A 1 292 ? -16.51952 -21.09637 28.09803  1.000 32.93458  ? 292 THR A N    1 
ATOM   4356 C CA   . THR A 1 292 ? -17.77080 -21.21134 28.83621  1.000 35.91652  ? 292 THR A CA   1 
ATOM   4357 C C    . THR A 1 292 ? -17.54348 -21.16008 30.35533  1.000 32.45294  ? 292 THR A C    1 
ATOM   4358 O O    . THR A 1 292 ? -16.42336 -21.37288 30.84224  1.000 32.90425  ? 292 THR A O    1 
ATOM   4359 C CB   . THR A 1 292 ? -18.49977 -22.52432 28.57062  1.000 34.57774  ? 292 THR A CB   1 
ATOM   4360 O OG1  . THR A 1 292 ? -17.75988 -23.58948 29.18386  1.000 39.92409  ? 292 THR A OG1  1 
ATOM   4361 C CG2  . THR A 1 292 ? -18.70106 -22.75803 27.09078  1.000 36.48792  ? 292 THR A CG2  1 
ATOM   4362 H H    . THR A 1 292 ? -16.22580 -21.83647 27.77312  1.000 39.57559  ? 292 THR A H    1 
ATOM   4363 H HA   . THR A 1 292 ? -18.31757 -20.46908 28.53458  1.000 43.15393  ? 292 THR A HA   1 
ATOM   4364 H HB   . THR A 1 292 ? -19.39049 -22.50042 28.95396  1.000 41.54739  ? 292 THR A HB   1 
ATOM   4365 H HG1  . THR A 1 292 ? -18.24785 -24.00103 29.72985  1.000 47.96300  ? 292 THR A HG1  1 
ATOM   4366 H HG21 . THR A 1 292 ? -17.84314 -22.87633 26.65387  1.000 43.83960  ? 292 THR A HG21 1 
ATOM   4367 H HG22 . THR A 1 292 ? -19.23808 -23.55355 26.95057  1.000 43.83960  ? 292 THR A HG22 1 
ATOM   4368 H HG23 . THR A 1 292 ? -19.15449 -21.99809 26.69355  1.000 43.83960  ? 292 THR A HG23 1 
ATOM   4369 N N    . PRO A 1 293 ? -18.59595 -20.91723 31.12034  1.000 36.12777  ? 293 PRO A N    1 
ATOM   4370 C CA   . PRO A 1 293 ? -18.45558 -21.04175 32.58306  1.000 34.26869  ? 293 PRO A CA   1 
ATOM   4371 C C    . PRO A 1 293 ? -17.94669 -22.40540 32.98540  1.000 42.75746  ? 293 PRO A C    1 
ATOM   4372 O O    . PRO A 1 293 ? -17.04345 -22.49939 33.82839  1.000 38.91264  ? 293 PRO A O    1 
ATOM   4373 C CB   . PRO A 1 293 ? -19.86754 -20.75787 33.08406  1.000 33.22684  ? 293 PRO A CB   1 
ATOM   4374 C CG   . PRO A 1 293 ? -20.44264 -19.85311 32.05404  1.000 36.72774  ? 293 PRO A CG   1 
ATOM   4375 C CD   . PRO A 1 293 ? -19.89727 -20.35315 30.72776  1.000 37.33208  ? 293 PRO A CD   1 
ATOM   4376 H HA   . PRO A 1 293 ? -17.86480 -20.36064 32.94076  1.000 41.17653  ? 293 PRO A HA   1 
ATOM   4377 H HB2  . PRO A 1 293 ? -20.37214 -21.58399 33.14582  1.000 39.92631  ? 293 PRO A HB2  1 
ATOM   4378 H HB3  . PRO A 1 293 ? -19.83314 -20.32451 33.95119  1.000 39.92631  ? 293 PRO A HB3  1 
ATOM   4379 H HG2  . PRO A 1 293 ? -21.41093 -19.90789 32.07176  1.000 44.12738  ? 293 PRO A HG2  1 
ATOM   4380 H HG3  . PRO A 1 293 ? -20.15883 -18.94090 32.22205  1.000 44.12738  ? 293 PRO A HG3  1 
ATOM   4381 H HD2  . PRO A 1 293 ? -20.47331 -21.03477 30.34767  1.000 44.85260  ? 293 PRO A HD2  1 
ATOM   4382 H HD3  . PRO A 1 293 ? -19.78636 -19.62366 30.09813  1.000 44.85260  ? 293 PRO A HD3  1 
ATOM   4383 N N    . PHE A 1 294 ? -18.47607 -23.47014 32.36522  1.000 40.25545  ? 294 PHE A N    1 
ATOM   4384 C CA   . PHE A 1 294 ? -17.98642 -24.81142 32.66942  1.000 40.63509  ? 294 PHE A CA   1 
ATOM   4385 C C    . PHE A 1 294 ? -16.51207 -24.93912 32.33736  1.000 39.18886  ? 294 PHE A C    1 
ATOM   4386 O O    . PHE A 1 294 ? -15.74677 -25.53132 33.10774  1.000 45.90507  ? 294 PHE A O    1 
ATOM   4387 C CB   . PHE A 1 294 ? -18.81726 -25.85478 31.91809  1.000 42.69764  ? 294 PHE A CB   1 
ATOM   4388 H H    . PHE A 1 294 ? -19.10453 -23.43911 31.77898  1.000 48.36065  ? 294 PHE A H    1 
ATOM   4389 H HA   . PHE A 1 294 ? -18.09119 -24.98314 33.61834  1.000 48.81621  ? 294 PHE A HA   1 
ATOM   4390 N N    . ASP A 1 295 ? -16.08321 -24.37064 31.19849  1.000 42.38089  ? 295 ASP A N    1 
ATOM   4391 C CA   . ASP A 1 295 ? -14.67038 -24.35117 30.84362  1.000 35.95425  ? 295 ASP A CA   1 
ATOM   4392 C C    . ASP A 1 295 ? -13.81816 -23.75197 31.94909  1.000 44.05633  ? 295 ASP A C    1 
ATOM   4393 O O    . ASP A 1 295 ? -12.75170 -24.27104 32.28245  1.000 44.00143  ? 295 ASP A O    1 
ATOM   4394 C CB   . ASP A 1 295 ? -14.43748 -23.55812 29.54871  1.000 38.88823  ? 295 ASP A CB   1 
ATOM   4395 C CG   . ASP A 1 295 ? -14.96875 -24.26909 28.32862  1.000 45.63086  ? 295 ASP A CG   1 
ATOM   4396 O OD1  . ASP A 1 295 ? -15.15994 -25.50079 28.40405  1.000 39.91167  ? 295 ASP A OD1  1 
ATOM   4397 O OD2  . ASP A 1 295 ? -15.17819 -23.59472 27.29238  1.000 36.12685  ? 295 ASP A OD2  1 
ATOM   4398 H H    . ASP A 1 295 ? -16.59477 -23.99203 30.62008  1.000 50.91117  ? 295 ASP A H    1 
ATOM   4399 H HA   . ASP A 1 295 ? -14.40174 -25.27184 30.69835  1.000 43.19920  ? 295 ASP A HA   1 
ATOM   4400 H HB2  . ASP A 1 295 ? -14.88737 -22.70147 29.61691  1.000 46.71998  ? 295 ASP A HB2  1 
ATOM   4401 H HB3  . ASP A 1 295 ? -13.48460 -23.42365 29.42692  1.000 46.71998  ? 295 ASP A HB3  1 
ATOM   4402 N N    . VAL A 1 296 ? -14.26739 -22.61546 32.50285  1.000 41.96678  ? 296 VAL A N    1 
ATOM   4403 C CA   . VAL A 1 296 ? -13.50105 -21.91899 33.53245  1.000 44.73313  ? 296 VAL A CA   1 
ATOM   4404 C C    . VAL A 1 296 ? -13.46176 -22.73763 34.81229  1.000 42.89719  ? 296 VAL A C    1 
ATOM   4405 O O    . VAL A 1 296 ? -12.40976 -22.85838 35.44925  1.000 44.45831  ? 296 VAL A O    1 
ATOM   4406 C CB   . VAL A 1 296 ? -14.10916 -20.51882 33.76523  1.000 41.44594  ? 296 VAL A CB   1 
ATOM   4407 C CG1  . VAL A 1 296 ? -13.44171 -19.82112 34.94226  1.000 43.96511  ? 296 VAL A CG1  1 
ATOM   4408 C CG2  . VAL A 1 296 ? -13.93157 -19.65198 32.51845  1.000 36.33388  ? 296 VAL A CG2  1 
ATOM   4409 H H    . VAL A 1 296 ? -15.00964 -22.23251 32.29789  1.000 50.41424  ? 296 VAL A H    1 
ATOM   4410 H HA   . VAL A 1 296 ? -12.58622 -21.80988 33.22900  1.000 53.73386  ? 296 VAL A HA   1 
ATOM   4411 H HB   . VAL A 1 296 ? -15.05327 -20.63033 33.95794  1.000 49.78922  ? 296 VAL A HB   1 
ATOM   4412 H HG11 . VAL A 1 296 ? -13.73080 -18.89550 34.96599  1.000 52.81223  ? 296 VAL A HG11 1 
ATOM   4413 H HG12 . VAL A 1 296 ? -13.69982 -20.26941 35.76282  1.000 52.81223  ? 296 VAL A HG12 1 
ATOM   4414 H HG13 . VAL A 1 296 ? -12.47914 -19.86426 34.83045  1.000 52.81223  ? 296 VAL A HG13 1 
ATOM   4415 H HG21 . VAL A 1 296 ? -14.28897 -18.76770 32.69510  1.000 43.65476  ? 296 VAL A HG21 1 
ATOM   4416 H HG22 . VAL A 1 296 ? -12.98659 -19.59090 32.30827  1.000 43.65476  ? 296 VAL A HG22 1 
ATOM   4417 H HG23 . VAL A 1 296 ? -14.40910 -20.06019 31.77938  1.000 43.65476  ? 296 VAL A HG23 1 
ATOM   4418 N N    . VAL A 1 297 ? -14.60364 -23.29862 35.21512  1.000 42.08198  ? 297 VAL A N    1 
ATOM   4419 C CA   . VAL A 1 297 ? -14.65454 -24.12742 36.42101  1.000 46.18615  ? 297 VAL A CA   1 
ATOM   4420 C C    . VAL A 1 297 ? -13.80368 -25.38141 36.25363  1.000 53.45184  ? 297 VAL A C    1 
ATOM   4421 O O    . VAL A 1 297 ? -12.99289 -25.71803 37.12767  1.000 54.61173  ? 297 VAL A O    1 
ATOM   4422 C CB   . VAL A 1 297 ? -16.11358 -24.49415 36.75284  1.000 43.77306  ? 297 VAL A CB   1 
ATOM   4423 C CG1  . VAL A 1 297 ? -16.16158 -25.61802 37.77376  1.000 47.32845  ? 297 VAL A CG1  1 
ATOM   4424 C CG2  . VAL A 1 297 ? -16.85102 -23.27992 37.27414  1.000 48.56503  ? 297 VAL A CG2  1 
ATOM   4425 H H    . VAL A 1 297 ? -15.35837 -23.21594 34.81121  1.000 50.55247  ? 297 VAL A H    1 
ATOM   4426 H HA   . VAL A 1 297 ? -14.28702 -23.61255 37.15636  1.000 55.47748  ? 297 VAL A HA   1 
ATOM   4427 H HB   . VAL A 1 297 ? -16.55318 -24.79984 35.94401  1.000 52.58177  ? 297 VAL A HB   1 
ATOM   4428 H HG11 . VAL A 1 297 ? -15.36542 -25.57692 38.32634  1.000 56.84825  ? 297 VAL A HG11 1 
ATOM   4429 H HG12 . VAL A 1 297 ? -16.95258 -25.51053 38.32481  1.000 56.84825  ? 297 VAL A HG12 1 
ATOM   4430 H HG13 . VAL A 1 297 ? -16.19666 -26.46752 37.30684  1.000 56.84825  ? 297 VAL A HG13 1 
ATOM   4431 H HG21 . VAL A 1 297 ? -17.76529 -23.53007 37.48017  1.000 58.33213  ? 297 VAL A HG21 1 
ATOM   4432 H HG22 . VAL A 1 297 ? -16.40694 -22.96057 38.07521  1.000 58.33213  ? 297 VAL A HG22 1 
ATOM   4433 H HG23 . VAL A 1 297 ? -16.84252 -22.58894 36.59343  1.000 58.33213  ? 297 VAL A HG23 1 
ATOM   4434 N N    . ARG A 1 298 ? -14.01009 -26.12012 35.15391  1.000 60.75040  ? 298 ARG A N    1 
ATOM   4435 C CA   . ARG A 1 298 ? -13.26846 -27.36359 34.93705  1.000 51.53056  ? 298 ARG A CA   1 
ATOM   4436 C C    . ARG A 1 298 ? -11.76749 -27.12494 35.03953  1.000 47.69626  ? 298 ARG A C    1 
ATOM   4437 O O    . ARG A 1 298 ? -11.03374 -27.93952 35.61264  1.000 53.48630  ? 298 ARG A O    1 
ATOM   4438 C CB   . ARG A 1 298 ? -13.61370 -27.96810 33.56717  1.000 42.85852  ? 298 ARG A CB   1 
ATOM   4439 H H    . ARG A 1 298 ? -14.56665 -25.92420 34.52823  1.000 72.95458  ? 298 ARG A H    1 
ATOM   4440 H HA   . ARG A 1 298 ? -13.53157 -28.00268 35.61766  1.000 61.89078  ? 298 ARG A HA   1 
ATOM   4441 N N    . GLN A 1 299 ? -11.29836 -25.99638 34.49887  1.000 48.40707  ? 299 GLN A N    1 
ATOM   4442 C CA   . GLN A 1 299 ? -9.87172  -25.71960 34.44727  1.000 50.82237  ? 299 GLN A CA   1 
ATOM   4443 C C    . GLN A 1 299 ? -9.34174  -25.10309 35.73285  1.000 48.27746  ? 299 GLN A C    1 
ATOM   4444 O O    . GLN A 1 299 ? -8.15400  -25.24031 36.03252  1.000 55.70371  ? 299 GLN A O    1 
ATOM   4445 C CB   . GLN A 1 299 ? -9.54161  -24.77278 33.29208  1.000 45.85321  ? 299 GLN A CB   1 
ATOM   4446 C CG   . GLN A 1 299 ? -8.05596  -24.46996 33.24389  1.000 33.89021  ? 299 GLN A CG   1 
ATOM   4447 C CD   . GLN A 1 299 ? -7.58920  -23.70645 32.00392  1.000 38.08707  ? 299 GLN A CD   1 
ATOM   4448 O OE1  . GLN A 1 299 ? -6.47630  -23.19117 32.00475  1.000 32.09303  ? 299 GLN A OE1  1 
ATOM   4449 N NE2  . GLN A 1 299 ? -8.42296  -23.62829 30.95847  1.000 41.13306  ? 299 GLN A NE2  1 
ATOM   4450 H H    . GLN A 1 299 ? -11.78906 -25.37852 34.15672  1.000 58.14259  ? 299 GLN A H    1 
ATOM   4451 H HA   . GLN A 1 299 ? -9.42474  -26.56751 34.29839  1.000 61.04095  ? 299 GLN A HA   1 
ATOM   4452 H HB2  . GLN A 1 299 ? -9.79871  -25.18614 32.45307  1.000 55.07796  ? 299 GLN A HB2  1 
ATOM   4453 H HB3  . GLN A 1 299 ? -10.02190 -23.93858 33.41182  1.000 55.07796  ? 299 GLN A HB3  1 
ATOM   4454 H HG2  . GLN A 1 299 ? -7.82686  -23.93276 34.01838  1.000 40.72235  ? 299 GLN A HG2  1 
ATOM   4455 H HG3  . GLN A 1 299 ? -7.57062  -25.30949 33.26712  1.000 40.72235  ? 299 GLN A HG3  1 
ATOM   4456 H HE21 . GLN A 1 299 ? -9.19670  -24.00174 30.99667  1.000 49.41377  ? 299 GLN A HE21 1 
ATOM   4457 H HE22 . GLN A 1 299 ? -8.18453  -23.20465 30.24904  1.000 49.41377  ? 299 GLN A HE22 1 
ATOM   4458 N N    . CYS A 1 300 ? -10.17850 -24.40937 36.48389  1.000 51.62197  ? 300 CYS A N    1 
ATOM   4459 C CA   . CYS A 1 300 ? -9.76092  -23.87359 37.77174  1.000 57.07847  ? 300 CYS A CA   1 
ATOM   4460 C C    . CYS A 1 300 ? -10.01660 -24.86290 38.91651  1.000 57.08991  ? 300 CYS A C    1 
ATOM   4461 O O    . CYS A 1 300 ? -9.81711  -24.50763 40.08225  1.000 60.68661  ? 300 CYS A O    1 
ATOM   4462 C CB   . CYS A 1 300 ? -10.45705 -22.53309 38.02004  1.000 52.35694  ? 300 CYS A CB   1 
ATOM   4463 S SG   . CYS A 1 300 ? -10.02545 -21.19321 36.81641  1.000 66.06730  ? 300 CYS A SG   1 
ATOM   4464 H H    . CYS A 1 300 ? -10.99330 -24.23444 36.27153  1.000 62.00047  ? 300 CYS A H    1 
ATOM   4465 H HA   . CYS A 1 300 ? -8.80756  -23.69496 37.76206  1.000 68.54826  ? 300 CYS A HA   1 
ATOM   4466 H HB2  . CYS A 1 300 ? -11.41587 -22.67123 37.97028  1.000 62.88243  ? 300 CYS A HB2  1 
ATOM   4467 H HB3  . CYS A 1 300 ? -10.21253 -22.21942 38.90475  1.000 62.88243  ? 300 CYS A HB3  1 
ATOM   4468 H HG   . CYS A 1 300 ? -10.32186 -21.55146 35.71016  1.000 79.33487  ? 300 CYS A HG   1 
ATOM   4469 N N    . SER A 1 301 ? -10.42599 -26.11150 38.59834  1.000 57.75858  ? 301 SER A N    1 
ATOM   4470 C CA   . SER A 1 301 ? -10.58820 -27.15575 39.60253  1.000 58.22698  ? 301 SER A CA   1 
ATOM   4471 C C    . SER A 1 301 ? -10.10114 -28.53709 39.15559  1.000 61.92771  ? 301 SER A C    1 
ATOM   4472 O O    . SER A 1 301 ? -10.42467 -29.53324 39.82575  1.000 60.60018  ? 301 SER A O    1 
ATOM   4473 C CB   . SER A 1 301 ? -12.06089 -27.27408 40.02010  1.000 71.31339  ? 301 SER A CB   1 
ATOM   4474 O OG   . SER A 1 301 ? -12.82346 -27.90866 39.00534  1.000 79.56973  ? 301 SER A OG   1 
ATOM   4475 H H    . SER A 1 301 ? -10.61438 -26.36898 37.79971  1.000 69.36440  ? 301 SER A H    1 
ATOM   4476 H HA   . SER A 1 301 ? -10.05478 -26.89729 40.37035  1.000 69.92648  ? 301 SER A HA   1 
ATOM   4477 H HB2  . SER A 1 301 ? -12.11738 -27.80002 40.83317  1.000 85.63017  ? 301 SER A HB2  1 
ATOM   4478 H HB3  . SER A 1 301 ? -12.41784 -26.38543 40.17434  1.000 85.63017  ? 301 SER A HB3  1 
ATOM   4479 H HG   . SER A 1 301 ? -12.66242 -28.73305 38.99808  1.000 95.53777  ? 301 SER A HG   1 
ATOM   4480 N N    . GLY A 1 302 ? -9.35746  -28.64161 38.05056  1.000 60.25498  ? 302 GLY A N    1 
ATOM   4481 C CA   . GLY A 1 302 ? -8.69227  -29.88057 37.66049  1.000 50.60107  ? 302 GLY A CA   1 
ATOM   4482 C C    . GLY A 1 302 ? -9.57055  -30.99778 37.12820  1.000 47.14992  ? 302 GLY A C    1 
ATOM   4483 O O    . GLY A 1 302 ? -9.22301  -32.17745 37.31201  1.000 47.58022  ? 302 GLY A O    1 
ATOM   4484 H H    . GLY A 1 302 ? -9.22185  -27.99422 37.50093  1.000 72.36008  ? 302 GLY A H    1 
ATOM   4485 H HA2  . GLY A 1 302 ? -8.04531  -29.67156 36.96863  1.000 60.77538  ? 302 GLY A HA2  1 
ATOM   4486 H HA3  . GLY A 1 302 ? -8.22446  -30.22950 38.43528  1.000 60.77538  ? 302 GLY A HA3  1 
HETATM 4487 C C7   . UED B 2 .   ? -14.25483 -22.67303 -0.03041  1.000 39.80444  ? 401 UED A C7   1 
HETATM 4488 O O8   . UED B 2 .   ? -14.89932 -23.83886 -0.56927  1.000 35.84840  ? 401 UED A O8   1 
HETATM 4489 C C9   . UED B 2 .   ? -15.10601 -24.88399 0.25432   1.000 38.97228  ? 401 UED A C9   1 
HETATM 4490 O O10  . UED B 2 .   ? -14.91394 -24.80783 1.46412   1.000 34.82738  ? 401 UED A O10  1 
HETATM 4491 C C1   . UED B 2 .   ? -12.73689 -22.80102 -0.11385  1.000 44.28578  ? 401 UED A C1   1 
HETATM 4492 C C2   . UED B 2 .   ? -12.14644 -23.83734 -0.85318  1.000 48.17307  ? 401 UED A C2   1 
HETATM 4493 C C3   . UED B 2 .   ? -10.75074 -23.94907 -0.93362  1.000 43.65689  ? 401 UED A C3   1 
HETATM 4494 C C4   . UED B 2 .   ? -9.93893  -23.01941 -0.27405  1.000 49.27039  ? 401 UED A C4   1 
HETATM 4495 C C5   . UED B 2 .   ? -10.51474 -21.98665 0.46387   1.000 49.23811  ? 401 UED A C5   1 
HETATM 4496 C C6   . UED B 2 .   ? -11.90896 -21.87248 0.54862   1.000 47.95343  ? 401 UED A C6   1 
HETATM 4497 N N11  . UED B 2 .   ? -15.54982 -25.99985 -0.41197  1.000 37.50721  ? 401 UED A N11  1 
HETATM 4498 C C12  . UED B 2 .   ? -15.69310 -27.27397 0.30453   1.000 31.51354  ? 401 UED A C12  1 
HETATM 4499 C C17  . UED B 2 .   ? -14.27903 -27.74016 0.71584   1.000 35.52338  ? 401 UED A C17  1 
HETATM 4500 O O18  . UED B 2 .   ? -13.33697 -27.62947 -0.06785  1.000 35.69821  ? 401 UED A O18  1 
HETATM 4501 C C13  . UED B 2 .   ? -16.36724 -28.30588 -0.59171  1.000 34.12144  ? 401 UED A C13  1 
HETATM 4502 C C14  . UED B 2 .   ? -17.86957 -28.01759 -0.84237  1.000 38.22623  ? 401 UED A C14  1 
HETATM 4503 C C15  . UED B 2 .   ? -18.69706 -27.96173 0.46016   1.000 39.77711  ? 401 UED A C15  1 
HETATM 4504 C C16  . UED B 2 .   ? -18.47663 -29.04663 -1.82263  1.000 41.54696  ? 401 UED A C16  1 
HETATM 4505 N N19  . UED B 2 .   ? -14.10639 -28.23261 1.94175   1.000 32.40951  ? 401 UED A N19  1 
HETATM 4506 C C20  . UED B 2 .   ? -12.81508 -28.70633 2.44607   1.000 31.13717  ? 401 UED A C20  1 
HETATM 4507 C C21  . UED B 2 .   ? -12.94592 -30.20764 2.81285   1.000 33.10563  ? 401 UED A C21  1 
HETATM 4508 O O22  . UED B 2 .   ? -11.69476 -30.88935 2.89608   1.000 36.58691  ? 401 UED A O22  1 
HETATM 4509 C C24  . UED B 2 .   ? -12.29035 -27.80379 3.58789   1.000 31.05883  ? 401 UED A C24  1 
HETATM 4510 C C25  . UED B 2 .   ? -11.98113 -26.29218 3.11634   1.000 30.08176  ? 401 UED A C25  1 
HETATM 4511 C C26  . UED B 2 .   ? -10.69470 -26.16420 2.30047   1.000 35.06107  ? 401 UED A C26  1 
HETATM 4512 C C27  . UED B 2 .   ? -9.97753  -24.95493 2.83922   1.000 34.23190  ? 401 UED A C27  1 
HETATM 4513 N N28  . UED B 2 .   ? -10.50618 -24.72905 4.18282   1.000 33.49005  ? 401 UED A N28  1 
HETATM 4514 C C29  . UED B 2 .   ? -11.68449 -25.53269 4.39324   1.000 32.03452  ? 401 UED A C29  1 
HETATM 4515 O O30  . UED B 2 .   ? -12.31687 -25.52539 5.42972   1.000 33.52220  ? 401 UED A O30  1 
HETATM 4516 H H1   . UED B 2 .   ? -14.54692 -22.52741 1.01168   1.000 47.81944  ? 401 UED A H1   1 
HETATM 4517 H H2   . UED B 2 .   ? -14.57117 -21.78076 -0.57469  1.000 47.81944  ? 401 UED A H2   1 
HETATM 4518 H H3   . UED B 2 .   ? -12.76726 -24.55801 -1.36676  1.000 57.86179  ? 401 UED A H3   1 
HETATM 4519 H H4   . UED B 2 .   ? -10.30187 -24.75069 -1.50325  1.000 52.44237  ? 401 UED A H4   1 
HETATM 4520 H H5   . UED B 2 .   ? -8.86391  -23.10191 -0.33661  1.000 59.17857  ? 401 UED A H5   1 
HETATM 4521 H H6   . UED B 2 .   ? -9.88501  -21.27058 0.97304   1.000 59.13983  ? 401 UED A H6   1 
HETATM 4522 H H7   . UED B 2 .   ? -12.34612 -21.06797 1.12515   1.000 57.59822  ? 401 UED A H7   1 
HETATM 4523 H H8   . UED B 2 .   ? -15.77915 -25.94955 -1.39533  1.000 45.06275  ? 401 UED A H8   1 
HETATM 4524 H H9   . UED B 2 .   ? -16.34565 -27.17524 1.17579   1.000 37.87035  ? 401 UED A H9   1 
HETATM 4525 H H10  . UED B 2 .   ? -16.25622 -29.29895 -0.14885  1.000 40.99983  ? 401 UED A H10  1 
HETATM 4526 H H11  . UED B 2 .   ? -15.84136 -28.35418 -1.54867  1.000 40.99983  ? 401 UED A H11  1 
HETATM 4527 H H12  . UED B 2 .   ? -17.92281 -27.03858 -1.32089  1.000 45.92557  ? 401 UED A H12  1 
HETATM 4528 H H13  . UED B 2 .   ? -19.73998 -28.23613 0.29493   1.000 47.78664  ? 401 UED A H13  1 
HETATM 4529 H H14  . UED B 2 .   ? -18.70009 -26.96376 0.90099   1.000 47.78664  ? 401 UED A H14  1 
HETATM 4530 H H15  . UED B 2 .   ? -18.30955 -28.64085 1.22102   1.000 47.78664  ? 401 UED A H15  1 
HETATM 4531 H H16  . UED B 2 .   ? -18.15922 -28.88428 -2.85162  1.000 49.91045  ? 401 UED A H16  1 
HETATM 4532 H H17  . UED B 2 .   ? -18.20019 -30.07160 -1.57984  1.000 49.91045  ? 401 UED A H17  1 
HETATM 4533 H H18  . UED B 2 .   ? -19.56529 -29.02280 -1.83545  1.000 49.91045  ? 401 UED A H18  1 
HETATM 4534 H H19  . UED B 2 .   ? -14.89530 -28.28997 2.56979   1.000 38.94551  ? 401 UED A H19  1 
HETATM 4535 H H20  . UED B 2 .   ? -12.05046 -28.68562 1.66532   1.000 37.41871  ? 401 UED A H20  1 
HETATM 4536 H H21  . UED B 2 .   ? -11.38799 -28.25408 4.00677   1.000 37.32469  ? 401 UED A H21  1 
HETATM 4537 H H22  . UED B 2 .   ? -13.02316 -27.79770 4.39748   1.000 37.32469  ? 401 UED A H22  1 
HETATM 4538 H H23  . UED B 2 .   ? -12.79605 -25.82467 2.56170   1.000 36.15222  ? 401 UED A H23  1 
HETATM 4539 H H24  . UED B 2 .   ? -10.89049 -26.03540 1.23596   1.000 42.12738  ? 401 UED A H24  1 
HETATM 4540 H H25  . UED B 2 .   ? -10.05760 -27.04397 2.39103   1.000 42.12738  ? 401 UED A H25  1 
HETATM 4541 H H26  . UED B 2 .   ? -10.15970 -24.07069 2.22844   1.000 41.13238  ? 401 UED A H26  1 
HETATM 4542 H H27  . UED B 2 .   ? -8.90117  -25.11598 2.89935   1.000 41.13238  ? 401 UED A H27  1 
HETATM 4543 H H28  . UED B 2 .   ? -9.86260  -24.54080 4.93812   1.000 40.24216  ? 401 UED A H28  1 
HETATM 4544 H H31  . UED B 2 .   ? -11.06205 -30.35467 3.37435   1.000 43.95839  ? 401 UED A H31  1 
HETATM 4545 O O    . HOH C 3 .   ? -21.31389 -14.90893 16.12184  1.000 34.84007  ? 501 HOH A O    1 
HETATM 4546 O O    . HOH C 3 .   ? -10.94870 -35.48870 13.75326  1.000 32.46049  ? 502 HOH A O    1 
HETATM 4547 O O    . HOH C 3 .   ? -26.12631 -20.40480 2.90006   1.000 43.37683  ? 503 HOH A O    1 
HETATM 4548 O O    . HOH C 3 .   ? -26.34402 -17.73007 21.07432  1.000 64.86993  ? 504 HOH A O    1 
HETATM 4549 O O    . HOH C 3 .   ? -11.55573 -21.16842 20.93687  1.000 35.83322  ? 505 HOH A O    1 
HETATM 4550 O O    . HOH C 3 .   ? -22.65350 0.96478   36.11095  1.000 50.93632  ? 506 HOH A O    1 
HETATM 4551 O O    . HOH C 3 .   ? -20.70342 -48.16698 -9.48784  1.000 50.42151  ? 507 HOH A O    1 
HETATM 4552 O O    . HOH C 3 .   ? -25.26500 -17.51674 10.58839  1.000 34.42031  ? 508 HOH A O    1 
HETATM 4553 O O    . HOH C 3 .   ? -25.42855 -16.66664 2.15744   1.000 45.10088  ? 509 HOH A O    1 
HETATM 4554 O O    . HOH C 3 .   ? -17.43302 -53.81088 -1.19376  1.000 39.29100  ? 510 HOH A O    1 
HETATM 4555 O O    . HOH C 3 .   ? -29.65019 -32.93774 13.77764  1.000 47.72269  ? 511 HOH A O    1 
HETATM 4556 O O    . HOH C 3 .   ? -12.11832 -49.97418 1.08370   1.000 36.59991  ? 512 HOH A O    1 
HETATM 4557 O O    . HOH C 3 .   ? -19.78765 -7.80974  44.62301  1.000 46.85543  ? 513 HOH A O    1 
HETATM 4558 O O    . HOH C 3 .   ? -13.68539 -44.96663 -6.11520  1.000 50.58506  ? 514 HOH A O    1 
HETATM 4559 O O    . HOH C 3 .   ? -32.33711 -10.21835 30.34315  1.000 61.59876  ? 515 HOH A O    1 
HETATM 4560 O O    . HOH C 3 .   ? -19.05696 -37.63536 -8.93484  1.000 46.74867  ? 516 HOH A O    1 
HETATM 4561 O O    . HOH C 3 .   ? -4.48596  -25.39453 8.91548   1.000 42.14587  ? 517 HOH A O    1 
HETATM 4562 O O    . HOH C 3 .   ? -19.96739 -52.71448 -5.05582  1.000 37.71987  ? 518 HOH A O    1 
HETATM 4563 O O    . HOH C 3 .   ? -21.95370 -46.02359 14.55158  1.000 35.87582  ? 519 HOH A O    1 
HETATM 4564 O O    . HOH C 3 .   ? -19.20817 -15.27087 4.11654   1.000 39.26531  ? 520 HOH A O    1 
HETATM 4565 O O    . HOH C 3 .   ? -14.54209 -50.45593 -0.96958  1.000 44.37939  ? 521 HOH A O    1 
HETATM 4566 O O    . HOH C 3 .   ? -1.21735  -39.36564 19.82111  1.000 36.45935  ? 522 HOH A O    1 
HETATM 4567 O O    . HOH C 3 .   ? -24.76615 -21.88936 25.03233  1.000 40.00825  ? 523 HOH A O    1 
HETATM 4568 O O    . HOH C 3 .   ? -26.53792 -13.14261 19.05791  1.000 49.62068  ? 524 HOH A O    1 
HETATM 4569 O O    . HOH C 3 .   ? -28.14590 -3.70972  40.40753  1.000 38.64126  ? 525 HOH A O    1 
HETATM 4570 O O    . HOH C 3 .   ? -10.39537 -44.89941 20.37465  1.000 43.72516  ? 526 HOH A O    1 
HETATM 4571 O O    . HOH C 3 .   ? -11.95814 -20.35311 17.95008  1.000 42.50140  ? 527 HOH A O    1 
HETATM 4572 O O    . HOH C 3 .   ? -20.34686 -20.25069 37.50367  1.000 41.02682  ? 528 HOH A O    1 
HETATM 4573 O O    . HOH C 3 .   ? -14.87995 -20.49897 17.26148  1.000 32.30571  ? 529 HOH A O    1 
HETATM 4574 O O    . HOH C 3 .   ? -27.53276 -25.69261 17.92349  1.000 46.79910  ? 530 HOH A O    1 
HETATM 4575 O O    . HOH C 3 .   ? -28.31516 -25.15242 6.69759   1.000 43.88514  ? 531 HOH A O    1 
HETATM 4576 O O    . HOH C 3 .   ? -9.60949  -19.06006 12.41814  1.000 37.91947  ? 532 HOH A O    1 
HETATM 4577 O O    . HOH C 3 .   ? -21.21790 -39.84461 -9.42809  1.000 46.03120  ? 533 HOH A O    1 
HETATM 4578 O O    . HOH C 3 .   ? -15.19194 -1.61923  23.09006  1.000 50.62026  ? 534 HOH A O    1 
HETATM 4579 O O    . HOH C 3 .   ? -3.82345  -22.80021 23.96920  1.000 32.21867  ? 535 HOH A O    1 
HETATM 4580 O O    . HOH C 3 .   ? -26.29220 -17.89370 4.24824   1.000 42.58536  ? 536 HOH A O    1 
HETATM 4581 O O    . HOH C 3 .   ? -2.92999  -22.70278 41.65143  1.000 42.46337  ? 537 HOH A O    1 
HETATM 4582 O O    . HOH C 3 .   ? -7.62626  -46.66343 0.38070   1.000 44.43405  ? 538 HOH A O    1 
HETATM 4583 O O    . HOH C 3 .   ? -16.12041 -4.21279  39.69735  1.000 51.68999  ? 539 HOH A O    1 
HETATM 4584 O O    . HOH C 3 .   ? -7.64141  -35.96070 3.73440   1.000 37.72294  ? 540 HOH A O    1 
HETATM 4585 O O    . HOH C 3 .   ? -20.09793 -37.06508 26.85930  1.000 43.50107  ? 541 HOH A O    1 
HETATM 4586 O O    . HOH C 3 .   ? -5.42158  -28.10898 10.32107  1.000 35.23315  ? 542 HOH A O    1 
HETATM 4587 O O    . HOH C 3 .   ? -12.01009 -22.22416 23.91527  1.000 41.53988  ? 543 HOH A O    1 
HETATM 4588 O O    . HOH C 3 .   ? -26.69073 -28.57187 2.01403   1.000 33.36208  ? 544 HOH A O    1 
HETATM 4589 O O    . HOH C 3 .   ? -25.70064 -40.24858 11.70611  1.000 41.47722  ? 545 HOH A O    1 
HETATM 4590 O O    . HOH C 3 .   ? -15.28148 -7.04970  23.03644  1.000 39.62589  ? 546 HOH A O    1 
HETATM 4591 O O    . HOH C 3 .   ? -9.08657  -44.32124 1.21584   1.000 37.28351  ? 547 HOH A O    1 
HETATM 4592 O O    . HOH C 3 .   ? -21.14745 -55.10148 9.61517   1.000 47.18623  ? 548 HOH A O    1 
HETATM 4593 O O    . HOH C 3 .   ? -28.03683 -34.08720 -12.30076 1.000 50.71344  ? 549 HOH A O    1 
HETATM 4594 O O    . HOH C 3 .   ? -18.93620 -27.19940 25.88451  1.000 43.24065  ? 550 HOH A O    1 
HETATM 4595 O O    . HOH C 3 .   ? -21.35814 -24.44871 10.89085  1.000 28.38726  ? 551 HOH A O    1 
HETATM 4596 O O    . HOH C 3 .   ? -21.81497 -20.40632 26.96725  1.000 33.65114  ? 552 HOH A O    1 
HETATM 4597 O O    . HOH C 3 .   ? -28.98249 -42.84708 0.61209   1.000 41.27349  ? 553 HOH A O    1 
HETATM 4598 O O    . HOH C 3 .   ? -6.37287  -25.55563 1.37744   1.000 48.01457  ? 554 HOH A O    1 
HETATM 4599 O O    . HOH C 3 .   ? -29.84334 -10.53761 38.00053  1.000 47.99017  ? 555 HOH A O    1 
HETATM 4600 O O    . HOH C 3 .   ? -19.92092 -32.29394 22.33730  1.000 35.68105  ? 556 HOH A O    1 
HETATM 4601 O O    . HOH C 3 .   ? -28.40808 -24.08306 12.98636  1.000 38.63587  ? 557 HOH A O    1 
HETATM 4602 O O    . HOH C 3 .   ? -14.56172 -16.42132 27.35415  1.000 27.34174  ? 558 HOH A O    1 
HETATM 4603 O O    . HOH C 3 .   ? -28.28822 -33.21184 20.83942  1.000 40.44612  ? 559 HOH A O    1 
HETATM 4604 O O    . HOH C 3 .   ? -17.87772 -14.69858 9.25772   1.000 46.93101  ? 560 HOH A O    1 
HETATM 4605 O O    . HOH C 3 .   ? -18.08843 -26.13506 28.08619  1.000 40.84930  ? 561 HOH A O    1 
HETATM 4606 O O    . HOH C 3 .   ? -15.19683 -27.89676 25.68354  1.000 39.68718  ? 562 HOH A O    1 
HETATM 4607 O O    . HOH C 3 .   ? -24.63090 -32.85255 -10.03305 1.000 37.65008  ? 563 HOH A O    1 
HETATM 4608 O O    . HOH C 3 .   ? -27.93567 -27.59311 4.40158   1.000 33.34047  ? 564 HOH A O    1 
HETATM 4609 O O    . HOH C 3 .   ? -4.23834  -19.97781 25.77232  1.000 33.11434  ? 565 HOH A O    1 
HETATM 4610 O O    . HOH C 3 .   ? -10.08701 -24.48009 27.40103  1.000 39.96171  ? 566 HOH A O    1 
HETATM 4611 O O    . HOH C 3 .   ? -33.67026 -12.73655 32.67652  1.000 48.25738  ? 567 HOH A O    1 
HETATM 4612 O O    . HOH C 3 .   ? -26.22080 -4.60095  41.85557  1.000 45.93498  ? 568 HOH A O    1 
HETATM 4613 O O    . HOH C 3 .   ? -13.08798 -51.47555 -3.70503  1.000 38.39323  ? 569 HOH A O    1 
HETATM 4614 O O    . HOH C 3 .   ? -27.31398 -17.95047 18.26579  1.000 41.70484  ? 570 HOH A O    1 
HETATM 4615 O O    . HOH C 3 .   ? -12.43838 -6.91796  22.93712  1.000 42.44117  ? 571 HOH A O    1 
HETATM 4616 O O    . HOH C 3 .   ? -23.95938 -34.77178 16.43148  1.000 34.95112  ? 572 HOH A O    1 
HETATM 4617 O O    . HOH C 3 .   ? -25.30464 -46.81899 5.30954   1.000 42.04751  ? 573 HOH A O    1 
HETATM 4618 O O    . HOH C 3 .   ? -20.58397 -32.27643 2.21694   1.000 27.79796  ? 574 HOH A O    1 
HETATM 4619 O O    . HOH C 3 .   ? -4.63347  -23.10214 36.88096  1.000 45.33408  ? 575 HOH A O    1 
HETATM 4620 O O    . HOH C 3 .   ? -11.46789 -18.05732 11.11554  1.000 42.53987  ? 576 HOH A O    1 
HETATM 4621 O O    . HOH C 3 .   ? -24.40205 -14.48425 26.81138  1.000 42.61049  ? 577 HOH A O    1 
HETATM 4622 O O    . HOH C 3 .   ? -12.75265 -23.75623 25.80259  1.000 35.68868  ? 578 HOH A O    1 
HETATM 4623 O O    . HOH C 3 .   ? -3.98308  -50.30834 0.20389   1.000 53.05729  ? 579 HOH A O    1 
HETATM 4624 O O    . HOH C 3 .   ? -26.04855 -45.22794 -4.93617  1.000 40.05145  ? 580 HOH A O    1 
HETATM 4625 O O    . HOH C 3 .   ? -29.55021 -35.66370 1.88503   1.000 39.21460  ? 581 HOH A O    1 
HETATM 4626 O O    . HOH C 3 .   ? -18.31420 -15.44613 11.74353  1.000 34.85104  ? 582 HOH A O    1 
HETATM 4627 O O    . HOH C 3 .   ? -6.84947  -25.06220 22.11525  1.000 26.57446  ? 583 HOH A O    1 
HETATM 4628 O O    . HOH C 3 .   ? -23.42736 -50.79965 -4.05494  1.000 37.26238  ? 584 HOH A O    1 
HETATM 4629 O O    . HOH C 3 .   ? -1.13483  -15.31305 38.84920  1.000 51.75281  ? 585 HOH A O    1 
HETATM 4630 O O    . HOH C 3 .   ? -28.32511 -32.02739 -4.01213  1.000 43.40836  ? 586 HOH A O    1 
HETATM 4631 O O    . HOH C 3 .   ? -6.38816  -12.43029 21.32152  1.000 48.91178  ? 587 HOH A O    1 
HETATM 4632 O O    . HOH C 3 .   ? -14.76862 -45.17595 26.43265  1.000 46.92513  ? 588 HOH A O    1 
HETATM 4633 O O    . HOH C 3 .   ? -28.15144 -29.24402 6.67317   1.000 33.15705  ? 589 HOH A O    1 
HETATM 4634 O O    . HOH C 3 .   ? -6.31381  -43.96082 9.37839   1.000 45.28037  ? 590 HOH A O    1 
HETATM 4635 O O    . HOH C 3 .   ? -24.98585 3.89254   30.57928  1.000 55.06213  ? 591 HOH A O    1 
HETATM 4636 O O    . HOH C 3 .   ? -20.02599 -9.35757  12.10825  1.000 49.40525  ? 592 HOH A O    1 
HETATM 4637 O O    . HOH C 3 .   ? -28.84317 -41.06583 -4.20975  1.000 40.67433  ? 593 HOH A O    1 
HETATM 4638 O O    . HOH C 3 .   ? -10.96595 -25.06483 30.02314  1.000 37.27186  ? 594 HOH A O    1 
HETATM 4639 O O    . HOH C 3 .   ? -8.89214  -49.23307 14.88905  1.000 45.14277  ? 595 HOH A O    1 
HETATM 4640 O O    . HOH C 3 .   ? -26.27278 -49.96008 0.42147   1.000 42.97074  ? 596 HOH A O    1 
HETATM 4641 O O    . HOH C 3 .   ? -21.22487 -54.94837 -1.46612  1.000 37.04553  ? 597 HOH A O    1 
HETATM 4642 O O    . HOH C 3 .   ? -17.64898 -11.29063 18.27541  1.000 47.38670  ? 598 HOH A O    1 
HETATM 4643 O O    . HOH C 3 .   ? -22.98053 -44.17160 25.11271  1.000 56.77538  ? 599 HOH A O    1 
HETATM 4644 O O    . HOH C 3 .   ? -21.50491 -45.91927 23.27875  1.000 44.42811  ? 600 HOH A O    1 
HETATM 4645 O O    . HOH C 3 .   ? -21.06666 -23.52904 30.80217  1.000 38.83444  ? 601 HOH A O    1 
HETATM 4646 O O    . HOH C 3 .   ? -26.25731 -27.59681 -5.04077  1.000 54.97404  ? 602 HOH A O    1 
HETATM 4647 O O    . HOH C 3 .   ? -3.32536  -30.38459 3.22755   1.000 48.32241  ? 603 HOH A O    1 
HETATM 4648 O O    . HOH C 3 .   ? -31.55781 -37.64600 4.68009   1.000 46.98960  ? 604 HOH A O    1 
HETATM 4649 O O    . HOH C 3 .   ? -4.84508  -10.16921 22.29256  0.50  34.16632  ? 605 HOH A O    1 
HETATM 4650 O O    . HOH C 3 .   ? -29.22096 -12.84670 40.65941  1.000 39.53762  ? 606 HOH A O    1 
HETATM 4651 O O    . HOH C 3 .   ? -30.056   -21.913   3.814     1.000 46.51572  ? 607 HOH A O    1 
HETATM 4652 O O    . HOH C 3 .   ? -19.95956 -47.47367 22.03670  1.000 49.35430  ? 608 HOH A O    1 
HETATM 4653 O O    . HOH C 3 .   ? -26.46515 -40.66441 20.21382  1.000 44.29538  ? 609 HOH A O    1 
HETATM 4654 O O    . HOH C 3 .   ? -4.84508  -27.10557 22.29256  0.50  31.72375  ? 610 HOH A O    1 
HETATM 4655 O O    . HOH C 3 .   ? -15.05175 -52.63500 -0.39542  1.000 35.03841  ? 611 HOH A O    1 
HETATM 4656 O O    . HOH C 3 .   ? -25.80675 -9.62973  40.75627  1.000 44.54990  ? 612 HOH A O    1 
HETATM 4657 O O    . HOH C 3 .   ? -2.22946  -17.43023 32.47795  1.000 41.76424  ? 613 HOH A O    1 
HETATM 4658 O O    . HOH C 3 .   ? -9.268    -39.617   27.245    1.000 52.61844  ? 614 HOH A O    1 
HETATM 4659 O O    . HOH C 3 .   ? -29.14227 -25.19819 15.65942  1.000 42.94580  ? 615 HOH A O    1 
HETATM 4660 O O    . HOH C 3 .   ? -22.54738 -22.08510 29.32194  1.000 50.89504  ? 616 HOH A O    1 
HETATM 4661 O O    . HOH C 3 .   ? -11.19358 0.51743   37.48398  1.000 56.23017  ? 617 HOH A O    1 
HETATM 4662 O O    . HOH C 3 .   ? -3.409    -42.843   20.052    1.000 51.40369  ? 618 HOH A O    1 
HETATM 4663 O O    . HOH C 3 .   ? -17.12023 -56.74715 -0.65879  1.000 39.77928  ? 619 HOH A O    1 
HETATM 4664 O O    . HOH C 3 .   ? -19.61109 -12.19181 9.44689   1.000 50.27308  ? 620 HOH A O    1 
HETATM 4665 O O    . HOH C 3 .   ? -11.80226 -34.57041 37.92926  1.000 51.00677  ? 621 HOH A O    1 
HETATM 4666 O O    . HOH C 3 .   ? -28.20605 -28.55266 -0.10516  1.000 47.07235  ? 622 HOH A O    1 
HETATM 4667 O O    . HOH C 3 .   ? -26.91075 -34.98890 16.32450  1.000 48.25793  ? 623 HOH A O    1 
HETATM 4668 O O    . HOH C 3 .   ? -27.45951 -44.35410 -1.52023  1.000 38.68365  ? 624 HOH A O    1 
HETATM 4669 O O    . HOH C 3 .   ? -7.843    -32.076   40.795    1.000 54.57276  ? 625 HOH A O    1 
HETATM 4670 O O    . HOH C 3 .   ? -13.65640 -13.67273 11.78125  1.000 53.21156  ? 626 HOH A O    1 
HETATM 4671 O O    . HOH C 3 .   ? -25.78914 -50.83966 -2.43802  1.000 44.51988  ? 627 HOH A O    1 
HETATM 4672 O O    . HOH C 3 .   ? -26.61037 -24.01271 26.28936  1.000 50.65951  ? 628 HOH A O    1 
HETATM 4673 O O    . HOH C 3 .   ? -28.21814 -43.81659 -4.28380  1.000 38.17983  ? 629 HOH A O    1 
HETATM 4674 O O    . HOH C 3 .   ? -9.16569  -17.54755 14.72619  1.000 42.48278  ? 630 HOH A O    1 
HETATM 4675 O O    . HOH C 3 .   ? -17.63367 -37.13171 -12.69086 1.000 52.88334  ? 631 HOH A O    1 
HETATM 4676 O O    . HOH C 3 .   ? -24.15737 -19.61153 26.42983  1.000 53.77158  ? 632 HOH A O    1 
HETATM 4677 O O    . HOH C 3 .   ? -31.21632 -8.60609  38.24386  1.000 44.45148  ? 633 HOH A O    1 
HETATM 4678 O O    . HOH C 3 .   ? -26.81512 -41.74178 13.67890  1.000 48.24696  ? 634 HOH A O    1 
HETATM 4679 O O    . HOH C 3 .   ? -1.144    -43.260   18.201    1.000 54.19504  ? 635 HOH A O    1 
HETATM 4680 O O    . HOH C 3 .   ? -22.56654 -52.99283 -5.38587  1.000 45.83623  ? 636 HOH A O    1 
HETATM 4681 O O    . HOH C 3 .   ? -25.53665 -34.71723 -11.51626 1.000 45.34658  ? 637 HOH A O    1 
HETATM 4682 O O    . HOH C 3 .   ? -19.11034 -54.71420 -3.18949  1.000 42.03021  ? 638 HOH A O    1 
HETATM 4683 O O    . HOH C 3 .   ? -30.43016 -26.89212 4.27666   1.000 48.24509  ? 639 HOH A O    1 
HETATM 4684 O O    . HOH C 3 .   ? -16.600   -60.927   -2.230    1.000 40.75658  ? 640 HOH A O    1 
HETATM 4685 O O    . HOH C 3 .   ? -27.81237 -18.24083 12.09585  1.000 37.00191  ? 641 HOH A O    1 
HETATM 4686 O O    . HOH C 3 .   ? -11.77290 -4.15797  23.78052  1.000 55.13805  ? 642 HOH A O    1 
HETATM 4687 O O    . HOH C 3 .   ? -4.84508  -20.69397 22.29256  0.50  30.30571  ? 643 HOH A O    1 
HETATM 4688 O O    . HOH C 3 .   ? -27.99958 -41.01227 18.24324  1.000 55.75304  ? 644 HOH A O    1 
HETATM 4689 O O    . HOH C 3 .   ? -11.54020 -15.36137 11.80906  1.000 50.02682  ? 645 HOH A O    1 
HETATM 4690 O O    . HOH C 3 .   ? -15.79832 -4.08860  22.02120  1.000 47.24675  ? 646 HOH A O    1 
# 
