data_9BO9
# 
_entry.id   9BO9 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BO9         pdb_00009bo9 10.2210/pdb9bo9/pdb 
WWPDB D_1000283421 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-12 ? 
2 'Structure model' 1 1 2025-03-12 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
_pdbx_audit_revision_category.ordinal             1 
_pdbx_audit_revision_category.revision_ordinal    2 
_pdbx_audit_revision_category.data_content_type   'Structure model' 
_pdbx_audit_revision_category.category            citation 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
5 2 'Structure model' '_citation.title'                   
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BO9 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-03 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              karen.anderson@yale.edu 
_pdbx_contact_author.name_first         Karen 
_pdbx_contact_author.name_last          Anderson 
_pdbx_contact_author.name_mi            S 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-3433-0780 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Papini, C.'     1 0000-0002-6098-4959 
'Anderson, K.S.' 2 0000-0003-3433-0780 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Acs Bio Med Chem Au' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2694-2437 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            5 
_citation.language                  ? 
_citation.page_first                215 
_citation.page_last                 226 
_citation.title                     
'Exploring Possible Drug-Resistant Variants of SARS-CoV-2 Main Protease (M pro ) with Noncovalent Preclinical Candidate, Mpro61.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acsbiomedchemau.4c00109 
_citation.pdbx_database_id_PubMed   39990941 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Kenneson, J.R.'  1 ? 
primary 'Papini, C.'      2 ? 
primary 'Tang, S.'        3 ? 
primary 'Huynh, K.'       4 ? 
primary 'Zhang, C.H.'     5 ? 
primary 'Jorgensen, W.L.' 6 ? 
primary 'Anderson, K.S.'  7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '3C-like proteinase nsp5'                                                                              33837.602 
2   3.4.22.69 ? ? ? 
2 non-polymer syn 'N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide' 405.488   
2   ?         ? ? ? 
3 water       nat water                                                                                                  18.015    
220 ?         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQIAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQIAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide' UED 
3 water                                                                                                  HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   GLY n 
1 3   PHE n 
1 4   ARG n 
1 5   LYS n 
1 6   MET n 
1 7   ALA n 
1 8   PHE n 
1 9   PRO n 
1 10  SER n 
1 11  GLY n 
1 12  LYS n 
1 13  VAL n 
1 14  GLU n 
1 15  GLY n 
1 16  CYS n 
1 17  MET n 
1 18  VAL n 
1 19  GLN n 
1 20  VAL n 
1 21  THR n 
1 22  CYS n 
1 23  GLY n 
1 24  THR n 
1 25  THR n 
1 26  THR n 
1 27  LEU n 
1 28  ASN n 
1 29  GLY n 
1 30  LEU n 
1 31  TRP n 
1 32  LEU n 
1 33  ASP n 
1 34  ASP n 
1 35  VAL n 
1 36  VAL n 
1 37  TYR n 
1 38  CYS n 
1 39  PRO n 
1 40  ARG n 
1 41  HIS n 
1 42  VAL n 
1 43  ILE n 
1 44  CYS n 
1 45  THR n 
1 46  SER n 
1 47  GLU n 
1 48  ASP n 
1 49  MET n 
1 50  LEU n 
1 51  ASN n 
1 52  PRO n 
1 53  ASN n 
1 54  TYR n 
1 55  GLU n 
1 56  ASP n 
1 57  LEU n 
1 58  LEU n 
1 59  ILE n 
1 60  ARG n 
1 61  LYS n 
1 62  SER n 
1 63  ASN n 
1 64  HIS n 
1 65  ASN n 
1 66  PHE n 
1 67  LEU n 
1 68  VAL n 
1 69  GLN n 
1 70  ALA n 
1 71  GLY n 
1 72  ASN n 
1 73  VAL n 
1 74  GLN n 
1 75  LEU n 
1 76  ARG n 
1 77  VAL n 
1 78  ILE n 
1 79  GLY n 
1 80  HIS n 
1 81  SER n 
1 82  MET n 
1 83  GLN n 
1 84  ASN n 
1 85  CYS n 
1 86  VAL n 
1 87  LEU n 
1 88  LYS n 
1 89  LEU n 
1 90  LYS n 
1 91  VAL n 
1 92  ASP n 
1 93  THR n 
1 94  ALA n 
1 95  ASN n 
1 96  PRO n 
1 97  LYS n 
1 98  THR n 
1 99  PRO n 
1 100 LYS n 
1 101 TYR n 
1 102 LYS n 
1 103 PHE n 
1 104 VAL n 
1 105 ARG n 
1 106 ILE n 
1 107 GLN n 
1 108 PRO n 
1 109 GLY n 
1 110 GLN n 
1 111 THR n 
1 112 PHE n 
1 113 SER n 
1 114 VAL n 
1 115 LEU n 
1 116 ALA n 
1 117 CYS n 
1 118 TYR n 
1 119 ASN n 
1 120 GLY n 
1 121 SER n 
1 122 PRO n 
1 123 SER n 
1 124 GLY n 
1 125 VAL n 
1 126 TYR n 
1 127 GLN n 
1 128 CYS n 
1 129 ALA n 
1 130 MET n 
1 131 ARG n 
1 132 PRO n 
1 133 ASN n 
1 134 PHE n 
1 135 THR n 
1 136 ILE n 
1 137 LYS n 
1 138 GLY n 
1 139 SER n 
1 140 PHE n 
1 141 LEU n 
1 142 ASN n 
1 143 GLY n 
1 144 SER n 
1 145 CYS n 
1 146 GLY n 
1 147 SER n 
1 148 VAL n 
1 149 GLY n 
1 150 PHE n 
1 151 ASN n 
1 152 ILE n 
1 153 ASP n 
1 154 TYR n 
1 155 ASP n 
1 156 CYS n 
1 157 VAL n 
1 158 SER n 
1 159 PHE n 
1 160 CYS n 
1 161 TYR n 
1 162 MET n 
1 163 HIS n 
1 164 HIS n 
1 165 MET n 
1 166 GLU n 
1 167 LEU n 
1 168 PRO n 
1 169 THR n 
1 170 GLY n 
1 171 VAL n 
1 172 HIS n 
1 173 ALA n 
1 174 GLY n 
1 175 THR n 
1 176 ASP n 
1 177 LEU n 
1 178 GLU n 
1 179 GLY n 
1 180 ASN n 
1 181 PHE n 
1 182 TYR n 
1 183 GLY n 
1 184 PRO n 
1 185 PHE n 
1 186 VAL n 
1 187 ASP n 
1 188 ARG n 
1 189 GLN n 
1 190 ILE n 
1 191 ALA n 
1 192 GLN n 
1 193 ALA n 
1 194 ALA n 
1 195 GLY n 
1 196 THR n 
1 197 ASP n 
1 198 THR n 
1 199 THR n 
1 200 ILE n 
1 201 THR n 
1 202 VAL n 
1 203 ASN n 
1 204 VAL n 
1 205 LEU n 
1 206 ALA n 
1 207 TRP n 
1 208 LEU n 
1 209 TYR n 
1 210 ALA n 
1 211 ALA n 
1 212 VAL n 
1 213 ILE n 
1 214 ASN n 
1 215 GLY n 
1 216 ASP n 
1 217 ARG n 
1 218 TRP n 
1 219 PHE n 
1 220 LEU n 
1 221 ASN n 
1 222 ARG n 
1 223 PHE n 
1 224 THR n 
1 225 THR n 
1 226 THR n 
1 227 LEU n 
1 228 ASN n 
1 229 ASP n 
1 230 PHE n 
1 231 ASN n 
1 232 LEU n 
1 233 VAL n 
1 234 ALA n 
1 235 MET n 
1 236 LYS n 
1 237 TYR n 
1 238 ASN n 
1 239 TYR n 
1 240 GLU n 
1 241 PRO n 
1 242 LEU n 
1 243 THR n 
1 244 GLN n 
1 245 ASP n 
1 246 HIS n 
1 247 VAL n 
1 248 ASP n 
1 249 ILE n 
1 250 LEU n 
1 251 GLY n 
1 252 PRO n 
1 253 LEU n 
1 254 SER n 
1 255 ALA n 
1 256 GLN n 
1 257 THR n 
1 258 GLY n 
1 259 ILE n 
1 260 ALA n 
1 261 VAL n 
1 262 LEU n 
1 263 ASP n 
1 264 MET n 
1 265 CYS n 
1 266 ALA n 
1 267 SER n 
1 268 LEU n 
1 269 LYS n 
1 270 GLU n 
1 271 LEU n 
1 272 LEU n 
1 273 GLN n 
1 274 ASN n 
1 275 GLY n 
1 276 MET n 
1 277 ASN n 
1 278 GLY n 
1 279 ARG n 
1 280 THR n 
1 281 ILE n 
1 282 LEU n 
1 283 GLY n 
1 284 SER n 
1 285 ALA n 
1 286 LEU n 
1 287 LEU n 
1 288 GLU n 
1 289 ASP n 
1 290 GLU n 
1 291 PHE n 
1 292 THR n 
1 293 PRO n 
1 294 PHE n 
1 295 ASP n 
1 296 VAL n 
1 297 VAL n 
1 298 ARG n 
1 299 GLN n 
1 300 CYS n 
1 301 SER n 
1 302 GLY n 
1 303 VAL n 
1 304 THR n 
1 305 PHE n 
1 306 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   306 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'rep, 1a-1b' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                                                                                ? 
'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                                                                               ? 
'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                                                                             ? 
'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                                                                        ? 
'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE                                                                                               ? 
'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE                                                                                              ? 
'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                                                                        ? 
'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                                                                                ? 
'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                                                                                              ? 
'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                                                                                  ? 
'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                                                                             ? 
'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                                                                                ? 
'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                                                                                 ? 
'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                                                                                             ? 
'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE                                                                                          ? 
'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                                                                                                ? 
'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                                                                                 ? 
'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                                                                                              ? 
'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                                                                             ? 
'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                                                                               ? 
'C9 H11 N O3'    181.189 
UED non-polymer         . 'N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide' 
'GC373 bound form, GC376 bound form' 'C21 H31 N3 O5'  405.488 
VAL 'L-peptide linking' y VALINE                                                                                                 ? 
'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   1   1   SER SER A . n 
A 1 2   GLY 2   2   2   GLY GLY A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   ARG 4   4   4   ARG ARG A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   MET 6   6   6   MET MET A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   PRO 9   9   9   PRO PRO A . n 
A 1 10  SER 10  10  10  SER SER A . n 
A 1 11  GLY 11  11  11  GLY GLY A . n 
A 1 12  LYS 12  12  12  LYS LYS A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  GLY 15  15  15  GLY GLY A . n 
A 1 16  CYS 16  16  16  CYS CYS A . n 
A 1 17  MET 17  17  17  MET MET A . n 
A 1 18  VAL 18  18  18  VAL VAL A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  THR 21  21  21  THR THR A . n 
A 1 22  CYS 22  22  22  CYS CYS A . n 
A 1 23  GLY 23  23  23  GLY GLY A . n 
A 1 24  THR 24  24  24  THR THR A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  THR 26  26  26  THR THR A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  ASN 28  28  28  ASN ASN A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  TRP 31  31  31  TRP TRP A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  ASP 33  33  33  ASP ASP A . n 
A 1 34  ASP 34  34  34  ASP ASP A . n 
A 1 35  VAL 35  35  35  VAL VAL A . n 
A 1 36  VAL 36  36  36  VAL VAL A . n 
A 1 37  TYR 37  37  37  TYR TYR A . n 
A 1 38  CYS 38  38  38  CYS CYS A . n 
A 1 39  PRO 39  39  39  PRO PRO A . n 
A 1 40  ARG 40  40  40  ARG ARG A . n 
A 1 41  HIS 41  41  41  HIS HIS A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  ILE 43  43  43  ILE ILE A . n 
A 1 44  CYS 44  44  44  CYS CYS A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  SER 46  46  46  SER SER A . n 
A 1 47  GLU 47  47  47  GLU GLU A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  MET 49  49  49  MET MET A . n 
A 1 50  LEU 50  50  50  LEU LEU A . n 
A 1 51  ASN 51  51  51  ASN ASN A . n 
A 1 52  PRO 52  52  52  PRO PRO A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  TYR 54  54  54  TYR TYR A . n 
A 1 55  GLU 55  55  55  GLU GLU A . n 
A 1 56  ASP 56  56  56  ASP ASP A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  ILE 59  59  59  ILE ILE A . n 
A 1 60  ARG 60  60  60  ARG ARG A . n 
A 1 61  LYS 61  61  61  LYS LYS A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  ASN 63  63  63  ASN ASN A . n 
A 1 64  HIS 64  64  64  HIS HIS A . n 
A 1 65  ASN 65  65  65  ASN ASN A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  GLN 69  69  69  GLN GLN A . n 
A 1 70  ALA 70  70  70  ALA ALA A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  ASN 72  72  72  ASN ASN A . n 
A 1 73  VAL 73  73  73  VAL VAL A . n 
A 1 74  GLN 74  74  74  GLN GLN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  ARG 76  76  76  ARG ARG A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  GLY 79  79  79  GLY GLY A . n 
A 1 80  HIS 80  80  80  HIS HIS A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  MET 82  82  82  MET MET A . n 
A 1 83  GLN 83  83  83  GLN GLN A . n 
A 1 84  ASN 84  84  84  ASN ASN A . n 
A 1 85  CYS 85  85  85  CYS CYS A . n 
A 1 86  VAL 86  86  86  VAL VAL A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  LYS 88  88  88  LYS LYS A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  LYS 90  90  90  LYS LYS A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  ASP 92  92  92  ASP ASP A . n 
A 1 93  THR 93  93  93  THR THR A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  PRO 96  96  96  PRO PRO A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  PRO 99  99  99  PRO PRO A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 TYR 101 101 101 TYR TYR A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 PHE 103 103 103 PHE PHE A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 ARG 105 105 105 ARG ARG A . n 
A 1 106 ILE 106 106 106 ILE ILE A . n 
A 1 107 GLN 107 107 107 GLN GLN A . n 
A 1 108 PRO 108 108 108 PRO PRO A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 GLN 110 110 110 GLN GLN A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 PHE 112 112 112 PHE PHE A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 CYS 117 117 117 CYS CYS A . n 
A 1 118 TYR 118 118 118 TYR TYR A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 SER 123 123 123 SER SER A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 MET 130 130 130 MET MET A . n 
A 1 131 ARG 131 131 131 ARG ARG A . n 
A 1 132 PRO 132 132 132 PRO PRO A . n 
A 1 133 ASN 133 133 133 ASN ASN A . n 
A 1 134 PHE 134 134 134 PHE PHE A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 LYS 137 137 137 LYS LYS A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 PHE 140 140 140 PHE PHE A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 ASN 142 142 142 ASN ASN A . n 
A 1 143 GLY 143 143 143 GLY GLY A . n 
A 1 144 SER 144 144 144 SER SER A . n 
A 1 145 CYS 145 145 145 CYS CYS A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 GLY 149 149 149 GLY GLY A . n 
A 1 150 PHE 150 150 150 PHE PHE A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 ILE 152 152 152 ILE ILE A . n 
A 1 153 ASP 153 153 153 ASP ASP A . n 
A 1 154 TYR 154 154 154 TYR TYR A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 CYS 156 156 156 CYS CYS A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 SER 158 158 158 SER SER A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 CYS 160 160 160 CYS CYS A . n 
A 1 161 TYR 161 161 161 TYR TYR A . n 
A 1 162 MET 162 162 162 MET MET A . n 
A 1 163 HIS 163 163 163 HIS HIS A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 MET 165 165 165 MET MET A . n 
A 1 166 GLU 166 166 166 GLU GLU A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 PRO 168 168 168 PRO PRO A . n 
A 1 169 THR 169 169 169 THR THR A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 VAL 171 171 171 VAL VAL A . n 
A 1 172 HIS 172 172 172 HIS HIS A . n 
A 1 173 ALA 173 173 173 ALA ALA A . n 
A 1 174 GLY 174 174 174 GLY GLY A . n 
A 1 175 THR 175 175 175 THR THR A . n 
A 1 176 ASP 176 176 176 ASP ASP A . n 
A 1 177 LEU 177 177 177 LEU LEU A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 TYR 182 182 182 TYR TYR A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 VAL 186 186 186 VAL VAL A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 GLN 189 189 189 GLN GLN A . n 
A 1 190 ILE 190 190 190 ILE ILE A . n 
A 1 191 ALA 191 191 191 ALA ALA A . n 
A 1 192 GLN 192 192 192 GLN GLN A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 THR 196 196 196 THR THR A . n 
A 1 197 ASP 197 197 197 ASP ASP A . n 
A 1 198 THR 198 198 198 THR THR A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 ILE 200 200 200 ILE ILE A . n 
A 1 201 THR 201 201 201 THR THR A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 ALA 206 206 206 ALA ALA A . n 
A 1 207 TRP 207 207 207 TRP TRP A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ALA 210 210 210 ALA ALA A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ASN 214 214 214 ASN ASN A . n 
A 1 215 GLY 215 215 215 GLY GLY A . n 
A 1 216 ASP 216 216 216 ASP ASP A . n 
A 1 217 ARG 217 217 217 ARG ARG A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 ASN 221 221 221 ASN ASN A . n 
A 1 222 ARG 222 222 222 ARG ARG A . n 
A 1 223 PHE 223 223 223 PHE PHE A . n 
A 1 224 THR 224 224 224 THR THR A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 THR 226 226 226 THR THR A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 ASN 228 228 228 ASN ASN A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 PHE 230 230 230 PHE PHE A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 VAL 233 233 233 VAL VAL A . n 
A 1 234 ALA 234 234 234 ALA ALA A . n 
A 1 235 MET 235 235 235 MET MET A . n 
A 1 236 LYS 236 236 236 LYS LYS A . n 
A 1 237 TYR 237 237 237 TYR TYR A . n 
A 1 238 ASN 238 238 238 ASN ASN A . n 
A 1 239 TYR 239 239 239 TYR TYR A . n 
A 1 240 GLU 240 240 240 GLU GLU A . n 
A 1 241 PRO 241 241 241 PRO PRO A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 THR 243 243 243 THR THR A . n 
A 1 244 GLN 244 244 244 GLN GLN A . n 
A 1 245 ASP 245 245 245 ASP ASP A . n 
A 1 246 HIS 246 246 246 HIS HIS A . n 
A 1 247 VAL 247 247 247 VAL VAL A . n 
A 1 248 ASP 248 248 248 ASP ASP A . n 
A 1 249 ILE 249 249 249 ILE ILE A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 PRO 252 252 252 PRO PRO A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 SER 254 254 254 SER SER A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 THR 257 257 257 THR THR A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 ILE 259 259 259 ILE ILE A . n 
A 1 260 ALA 260 260 260 ALA ALA A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 LEU 262 262 262 LEU LEU A . n 
A 1 263 ASP 263 263 263 ASP ASP A . n 
A 1 264 MET 264 264 264 MET MET A . n 
A 1 265 CYS 265 265 265 CYS CYS A . n 
A 1 266 ALA 266 266 266 ALA ALA A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 LYS 269 269 269 LYS LYS A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 LEU 271 271 271 LEU LEU A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 ASN 274 274 274 ASN ASN A . n 
A 1 275 GLY 275 275 275 GLY GLY A . n 
A 1 276 MET 276 276 276 MET MET A . n 
A 1 277 ASN 277 277 277 ASN ASN A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 ARG 279 279 279 ARG ARG A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 ILE 281 281 281 ILE ILE A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 GLY 283 283 283 GLY GLY A . n 
A 1 284 SER 284 284 284 SER SER A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 LEU 286 286 286 LEU LEU A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 ASP 289 289 289 ASP ASP A . n 
A 1 290 GLU 290 290 290 GLU GLU A . n 
A 1 291 PHE 291 291 291 PHE PHE A . n 
A 1 292 THR 292 292 292 THR THR A . n 
A 1 293 PRO 293 293 293 PRO PRO A . n 
A 1 294 PHE 294 294 294 PHE PHE A . n 
A 1 295 ASP 295 295 295 ASP ASP A . n 
A 1 296 VAL 296 296 296 VAL VAL A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 GLN 299 299 299 GLN GLN A . n 
A 1 300 CYS 300 300 300 CYS CYS A . n 
A 1 301 SER 301 301 301 SER SER A . n 
A 1 302 GLY 302 302 ?   ?   ?   A . n 
A 1 303 VAL 303 303 ?   ?   ?   A . n 
A 1 304 THR 304 304 ?   ?   ?   A . n 
A 1 305 PHE 305 305 ?   ?   ?   A . n 
A 1 306 GLN 306 306 ?   ?   ?   A . n 
B 1 1   SER 1   1   1   SER SER B . n 
B 1 2   GLY 2   2   2   GLY GLY B . n 
B 1 3   PHE 3   3   3   PHE PHE B . n 
B 1 4   ARG 4   4   4   ARG ARG B . n 
B 1 5   LYS 5   5   5   LYS LYS B . n 
B 1 6   MET 6   6   6   MET MET B . n 
B 1 7   ALA 7   7   7   ALA ALA B . n 
B 1 8   PHE 8   8   8   PHE PHE B . n 
B 1 9   PRO 9   9   9   PRO PRO B . n 
B 1 10  SER 10  10  10  SER SER B . n 
B 1 11  GLY 11  11  11  GLY GLY B . n 
B 1 12  LYS 12  12  12  LYS LYS B . n 
B 1 13  VAL 13  13  13  VAL VAL B . n 
B 1 14  GLU 14  14  14  GLU GLU B . n 
B 1 15  GLY 15  15  15  GLY GLY B . n 
B 1 16  CYS 16  16  16  CYS CYS B . n 
B 1 17  MET 17  17  17  MET MET B . n 
B 1 18  VAL 18  18  18  VAL VAL B . n 
B 1 19  GLN 19  19  19  GLN GLN B . n 
B 1 20  VAL 20  20  20  VAL VAL B . n 
B 1 21  THR 21  21  21  THR THR B . n 
B 1 22  CYS 22  22  22  CYS CYS B . n 
B 1 23  GLY 23  23  23  GLY GLY B . n 
B 1 24  THR 24  24  24  THR THR B . n 
B 1 25  THR 25  25  25  THR THR B . n 
B 1 26  THR 26  26  26  THR THR B . n 
B 1 27  LEU 27  27  27  LEU LEU B . n 
B 1 28  ASN 28  28  28  ASN ASN B . n 
B 1 29  GLY 29  29  29  GLY GLY B . n 
B 1 30  LEU 30  30  30  LEU LEU B . n 
B 1 31  TRP 31  31  31  TRP TRP B . n 
B 1 32  LEU 32  32  32  LEU LEU B . n 
B 1 33  ASP 33  33  33  ASP ASP B . n 
B 1 34  ASP 34  34  34  ASP ASP B . n 
B 1 35  VAL 35  35  35  VAL VAL B . n 
B 1 36  VAL 36  36  36  VAL VAL B . n 
B 1 37  TYR 37  37  37  TYR TYR B . n 
B 1 38  CYS 38  38  38  CYS CYS B . n 
B 1 39  PRO 39  39  39  PRO PRO B . n 
B 1 40  ARG 40  40  40  ARG ARG B . n 
B 1 41  HIS 41  41  41  HIS HIS B . n 
B 1 42  VAL 42  42  42  VAL VAL B . n 
B 1 43  ILE 43  43  43  ILE ILE B . n 
B 1 44  CYS 44  44  44  CYS CYS B . n 
B 1 45  THR 45  45  45  THR THR B . n 
B 1 46  SER 46  46  46  SER SER B . n 
B 1 47  GLU 47  47  47  GLU GLU B . n 
B 1 48  ASP 48  48  48  ASP ASP B . n 
B 1 49  MET 49  49  49  MET MET B . n 
B 1 50  LEU 50  50  50  LEU LEU B . n 
B 1 51  ASN 51  51  51  ASN ASN B . n 
B 1 52  PRO 52  52  52  PRO PRO B . n 
B 1 53  ASN 53  53  53  ASN ASN B . n 
B 1 54  TYR 54  54  54  TYR TYR B . n 
B 1 55  GLU 55  55  55  GLU GLU B . n 
B 1 56  ASP 56  56  56  ASP ASP B . n 
B 1 57  LEU 57  57  57  LEU LEU B . n 
B 1 58  LEU 58  58  58  LEU LEU B . n 
B 1 59  ILE 59  59  59  ILE ILE B . n 
B 1 60  ARG 60  60  60  ARG ARG B . n 
B 1 61  LYS 61  61  61  LYS LYS B . n 
B 1 62  SER 62  62  62  SER SER B . n 
B 1 63  ASN 63  63  63  ASN ASN B . n 
B 1 64  HIS 64  64  64  HIS HIS B . n 
B 1 65  ASN 65  65  65  ASN ASN B . n 
B 1 66  PHE 66  66  66  PHE PHE B . n 
B 1 67  LEU 67  67  67  LEU LEU B . n 
B 1 68  VAL 68  68  68  VAL VAL B . n 
B 1 69  GLN 69  69  69  GLN GLN B . n 
B 1 70  ALA 70  70  70  ALA ALA B . n 
B 1 71  GLY 71  71  71  GLY GLY B . n 
B 1 72  ASN 72  72  72  ASN ASN B . n 
B 1 73  VAL 73  73  73  VAL VAL B . n 
B 1 74  GLN 74  74  74  GLN GLN B . n 
B 1 75  LEU 75  75  75  LEU LEU B . n 
B 1 76  ARG 76  76  76  ARG ARG B . n 
B 1 77  VAL 77  77  77  VAL VAL B . n 
B 1 78  ILE 78  78  78  ILE ILE B . n 
B 1 79  GLY 79  79  79  GLY GLY B . n 
B 1 80  HIS 80  80  80  HIS HIS B . n 
B 1 81  SER 81  81  81  SER SER B . n 
B 1 82  MET 82  82  82  MET MET B . n 
B 1 83  GLN 83  83  83  GLN GLN B . n 
B 1 84  ASN 84  84  84  ASN ASN B . n 
B 1 85  CYS 85  85  85  CYS CYS B . n 
B 1 86  VAL 86  86  86  VAL VAL B . n 
B 1 87  LEU 87  87  87  LEU LEU B . n 
B 1 88  LYS 88  88  88  LYS LYS B . n 
B 1 89  LEU 89  89  89  LEU LEU B . n 
B 1 90  LYS 90  90  90  LYS LYS B . n 
B 1 91  VAL 91  91  91  VAL VAL B . n 
B 1 92  ASP 92  92  92  ASP ASP B . n 
B 1 93  THR 93  93  93  THR THR B . n 
B 1 94  ALA 94  94  94  ALA ALA B . n 
B 1 95  ASN 95  95  95  ASN ASN B . n 
B 1 96  PRO 96  96  96  PRO PRO B . n 
B 1 97  LYS 97  97  97  LYS LYS B . n 
B 1 98  THR 98  98  98  THR THR B . n 
B 1 99  PRO 99  99  99  PRO PRO B . n 
B 1 100 LYS 100 100 100 LYS LYS B . n 
B 1 101 TYR 101 101 101 TYR TYR B . n 
B 1 102 LYS 102 102 102 LYS LYS B . n 
B 1 103 PHE 103 103 103 PHE PHE B . n 
B 1 104 VAL 104 104 104 VAL VAL B . n 
B 1 105 ARG 105 105 105 ARG ARG B . n 
B 1 106 ILE 106 106 106 ILE ILE B . n 
B 1 107 GLN 107 107 107 GLN GLN B . n 
B 1 108 PRO 108 108 108 PRO PRO B . n 
B 1 109 GLY 109 109 109 GLY GLY B . n 
B 1 110 GLN 110 110 110 GLN GLN B . n 
B 1 111 THR 111 111 111 THR THR B . n 
B 1 112 PHE 112 112 112 PHE PHE B . n 
B 1 113 SER 113 113 113 SER SER B . n 
B 1 114 VAL 114 114 114 VAL VAL B . n 
B 1 115 LEU 115 115 115 LEU LEU B . n 
B 1 116 ALA 116 116 116 ALA ALA B . n 
B 1 117 CYS 117 117 117 CYS CYS B . n 
B 1 118 TYR 118 118 118 TYR TYR B . n 
B 1 119 ASN 119 119 119 ASN ASN B . n 
B 1 120 GLY 120 120 120 GLY GLY B . n 
B 1 121 SER 121 121 121 SER SER B . n 
B 1 122 PRO 122 122 122 PRO PRO B . n 
B 1 123 SER 123 123 123 SER SER B . n 
B 1 124 GLY 124 124 124 GLY GLY B . n 
B 1 125 VAL 125 125 125 VAL VAL B . n 
B 1 126 TYR 126 126 126 TYR TYR B . n 
B 1 127 GLN 127 127 127 GLN GLN B . n 
B 1 128 CYS 128 128 128 CYS CYS B . n 
B 1 129 ALA 129 129 129 ALA ALA B . n 
B 1 130 MET 130 130 130 MET MET B . n 
B 1 131 ARG 131 131 131 ARG ARG B . n 
B 1 132 PRO 132 132 132 PRO PRO B . n 
B 1 133 ASN 133 133 133 ASN ASN B . n 
B 1 134 PHE 134 134 134 PHE PHE B . n 
B 1 135 THR 135 135 135 THR THR B . n 
B 1 136 ILE 136 136 136 ILE ILE B . n 
B 1 137 LYS 137 137 137 LYS LYS B . n 
B 1 138 GLY 138 138 138 GLY GLY B . n 
B 1 139 SER 139 139 139 SER SER B . n 
B 1 140 PHE 140 140 140 PHE PHE B . n 
B 1 141 LEU 141 141 141 LEU LEU B . n 
B 1 142 ASN 142 142 142 ASN ASN B . n 
B 1 143 GLY 143 143 143 GLY GLY B . n 
B 1 144 SER 144 144 144 SER SER B . n 
B 1 145 CYS 145 145 145 CYS CYS B . n 
B 1 146 GLY 146 146 146 GLY GLY B . n 
B 1 147 SER 147 147 147 SER SER B . n 
B 1 148 VAL 148 148 148 VAL VAL B . n 
B 1 149 GLY 149 149 149 GLY GLY B . n 
B 1 150 PHE 150 150 150 PHE PHE B . n 
B 1 151 ASN 151 151 151 ASN ASN B . n 
B 1 152 ILE 152 152 152 ILE ILE B . n 
B 1 153 ASP 153 153 153 ASP ASP B . n 
B 1 154 TYR 154 154 154 TYR TYR B . n 
B 1 155 ASP 155 155 155 ASP ASP B . n 
B 1 156 CYS 156 156 156 CYS CYS B . n 
B 1 157 VAL 157 157 157 VAL VAL B . n 
B 1 158 SER 158 158 158 SER SER B . n 
B 1 159 PHE 159 159 159 PHE PHE B . n 
B 1 160 CYS 160 160 160 CYS CYS B . n 
B 1 161 TYR 161 161 161 TYR TYR B . n 
B 1 162 MET 162 162 162 MET MET B . n 
B 1 163 HIS 163 163 163 HIS HIS B . n 
B 1 164 HIS 164 164 164 HIS HIS B . n 
B 1 165 MET 165 165 165 MET MET B . n 
B 1 166 GLU 166 166 166 GLU GLU B . n 
B 1 167 LEU 167 167 167 LEU LEU B . n 
B 1 168 PRO 168 168 168 PRO PRO B . n 
B 1 169 THR 169 169 169 THR THR B . n 
B 1 170 GLY 170 170 170 GLY GLY B . n 
B 1 171 VAL 171 171 171 VAL VAL B . n 
B 1 172 HIS 172 172 172 HIS HIS B . n 
B 1 173 ALA 173 173 173 ALA ALA B . n 
B 1 174 GLY 174 174 174 GLY GLY B . n 
B 1 175 THR 175 175 175 THR THR B . n 
B 1 176 ASP 176 176 176 ASP ASP B . n 
B 1 177 LEU 177 177 177 LEU LEU B . n 
B 1 178 GLU 178 178 178 GLU GLU B . n 
B 1 179 GLY 179 179 179 GLY GLY B . n 
B 1 180 ASN 180 180 180 ASN ASN B . n 
B 1 181 PHE 181 181 181 PHE PHE B . n 
B 1 182 TYR 182 182 182 TYR TYR B . n 
B 1 183 GLY 183 183 183 GLY GLY B . n 
B 1 184 PRO 184 184 184 PRO PRO B . n 
B 1 185 PHE 185 185 185 PHE PHE B . n 
B 1 186 VAL 186 186 186 VAL VAL B . n 
B 1 187 ASP 187 187 187 ASP ASP B . n 
B 1 188 ARG 188 188 188 ARG ARG B . n 
B 1 189 GLN 189 189 189 GLN GLN B . n 
B 1 190 ILE 190 190 190 ILE ILE B . n 
B 1 191 ALA 191 191 191 ALA ALA B . n 
B 1 192 GLN 192 192 192 GLN GLN B . n 
B 1 193 ALA 193 193 193 ALA ALA B . n 
B 1 194 ALA 194 194 194 ALA ALA B . n 
B 1 195 GLY 195 195 195 GLY GLY B . n 
B 1 196 THR 196 196 196 THR THR B . n 
B 1 197 ASP 197 197 197 ASP ASP B . n 
B 1 198 THR 198 198 198 THR THR B . n 
B 1 199 THR 199 199 199 THR THR B . n 
B 1 200 ILE 200 200 200 ILE ILE B . n 
B 1 201 THR 201 201 201 THR THR B . n 
B 1 202 VAL 202 202 202 VAL VAL B . n 
B 1 203 ASN 203 203 203 ASN ASN B . n 
B 1 204 VAL 204 204 204 VAL VAL B . n 
B 1 205 LEU 205 205 205 LEU LEU B . n 
B 1 206 ALA 206 206 206 ALA ALA B . n 
B 1 207 TRP 207 207 207 TRP TRP B . n 
B 1 208 LEU 208 208 208 LEU LEU B . n 
B 1 209 TYR 209 209 209 TYR TYR B . n 
B 1 210 ALA 210 210 210 ALA ALA B . n 
B 1 211 ALA 211 211 211 ALA ALA B . n 
B 1 212 VAL 212 212 212 VAL VAL B . n 
B 1 213 ILE 213 213 213 ILE ILE B . n 
B 1 214 ASN 214 214 214 ASN ASN B . n 
B 1 215 GLY 215 215 215 GLY GLY B . n 
B 1 216 ASP 216 216 216 ASP ASP B . n 
B 1 217 ARG 217 217 217 ARG ARG B . n 
B 1 218 TRP 218 218 218 TRP TRP B . n 
B 1 219 PHE 219 219 219 PHE PHE B . n 
B 1 220 LEU 220 220 220 LEU LEU B . n 
B 1 221 ASN 221 221 221 ASN ASN B . n 
B 1 222 ARG 222 222 222 ARG ARG B . n 
B 1 223 PHE 223 223 223 PHE PHE B . n 
B 1 224 THR 224 224 224 THR THR B . n 
B 1 225 THR 225 225 225 THR THR B . n 
B 1 226 THR 226 226 226 THR THR B . n 
B 1 227 LEU 227 227 227 LEU LEU B . n 
B 1 228 ASN 228 228 228 ASN ASN B . n 
B 1 229 ASP 229 229 229 ASP ASP B . n 
B 1 230 PHE 230 230 230 PHE PHE B . n 
B 1 231 ASN 231 231 231 ASN ASN B . n 
B 1 232 LEU 232 232 232 LEU LEU B . n 
B 1 233 VAL 233 233 233 VAL VAL B . n 
B 1 234 ALA 234 234 234 ALA ALA B . n 
B 1 235 MET 235 235 235 MET MET B . n 
B 1 236 LYS 236 236 236 LYS LYS B . n 
B 1 237 TYR 237 237 237 TYR TYR B . n 
B 1 238 ASN 238 238 238 ASN ASN B . n 
B 1 239 TYR 239 239 239 TYR TYR B . n 
B 1 240 GLU 240 240 240 GLU GLU B . n 
B 1 241 PRO 241 241 241 PRO PRO B . n 
B 1 242 LEU 242 242 242 LEU LEU B . n 
B 1 243 THR 243 243 243 THR THR B . n 
B 1 244 GLN 244 244 244 GLN GLN B . n 
B 1 245 ASP 245 245 245 ASP ASP B . n 
B 1 246 HIS 246 246 246 HIS HIS B . n 
B 1 247 VAL 247 247 247 VAL VAL B . n 
B 1 248 ASP 248 248 248 ASP ASP B . n 
B 1 249 ILE 249 249 249 ILE ILE B . n 
B 1 250 LEU 250 250 250 LEU LEU B . n 
B 1 251 GLY 251 251 251 GLY GLY B . n 
B 1 252 PRO 252 252 252 PRO PRO B . n 
B 1 253 LEU 253 253 253 LEU LEU B . n 
B 1 254 SER 254 254 254 SER SER B . n 
B 1 255 ALA 255 255 255 ALA ALA B . n 
B 1 256 GLN 256 256 256 GLN GLN B . n 
B 1 257 THR 257 257 257 THR THR B . n 
B 1 258 GLY 258 258 258 GLY GLY B . n 
B 1 259 ILE 259 259 259 ILE ILE B . n 
B 1 260 ALA 260 260 260 ALA ALA B . n 
B 1 261 VAL 261 261 261 VAL VAL B . n 
B 1 262 LEU 262 262 262 LEU LEU B . n 
B 1 263 ASP 263 263 263 ASP ASP B . n 
B 1 264 MET 264 264 264 MET MET B . n 
B 1 265 CYS 265 265 265 CYS CYS B . n 
B 1 266 ALA 266 266 266 ALA ALA B . n 
B 1 267 SER 267 267 267 SER SER B . n 
B 1 268 LEU 268 268 268 LEU LEU B . n 
B 1 269 LYS 269 269 269 LYS LYS B . n 
B 1 270 GLU 270 270 270 GLU GLU B . n 
B 1 271 LEU 271 271 271 LEU LEU B . n 
B 1 272 LEU 272 272 272 LEU LEU B . n 
B 1 273 GLN 273 273 273 GLN GLN B . n 
B 1 274 ASN 274 274 274 ASN ASN B . n 
B 1 275 GLY 275 275 275 GLY GLY B . n 
B 1 276 MET 276 276 276 MET MET B . n 
B 1 277 ASN 277 277 277 ASN ASN B . n 
B 1 278 GLY 278 278 278 GLY GLY B . n 
B 1 279 ARG 279 279 279 ARG ARG B . n 
B 1 280 THR 280 280 280 THR THR B . n 
B 1 281 ILE 281 281 281 ILE ILE B . n 
B 1 282 LEU 282 282 282 LEU LEU B . n 
B 1 283 GLY 283 283 283 GLY GLY B . n 
B 1 284 SER 284 284 284 SER SER B . n 
B 1 285 ALA 285 285 285 ALA ALA B . n 
B 1 286 LEU 286 286 286 LEU LEU B . n 
B 1 287 LEU 287 287 287 LEU LEU B . n 
B 1 288 GLU 288 288 288 GLU GLU B . n 
B 1 289 ASP 289 289 289 ASP ASP B . n 
B 1 290 GLU 290 290 290 GLU GLU B . n 
B 1 291 PHE 291 291 291 PHE PHE B . n 
B 1 292 THR 292 292 292 THR THR B . n 
B 1 293 PRO 293 293 293 PRO PRO B . n 
B 1 294 PHE 294 294 294 PHE PHE B . n 
B 1 295 ASP 295 295 295 ASP ASP B . n 
B 1 296 VAL 296 296 296 VAL VAL B . n 
B 1 297 VAL 297 297 297 VAL VAL B . n 
B 1 298 ARG 298 298 298 ARG ARG B . n 
B 1 299 GLN 299 299 299 GLN GLN B . n 
B 1 300 CYS 300 300 300 CYS CYS B . n 
B 1 301 SER 301 301 301 SER SER B . n 
B 1 302 GLY 302 302 ?   ?   ?   B . n 
B 1 303 VAL 303 303 ?   ?   ?   B . n 
B 1 304 THR 304 304 ?   ?   ?   B . n 
B 1 305 PHE 305 305 ?   ?   ?   B . n 
B 1 306 GLN 306 306 ?   ?   ?   B . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 UED ? ? UED ? ? 'SUBJECT OF INVESTIGATION' ? 
2 UED ? ? UED ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 UED 1   401 999 UED GCA A . 
D 2 UED 1   401 999 UED GCB B . 
E 3 HOH 1   501 117 HOH HOH A . 
E 3 HOH 2   502 95  HOH HOH A . 
E 3 HOH 3   503 104 HOH HOH A . 
E 3 HOH 4   504 114 HOH HOH A . 
E 3 HOH 5   505 214 HOH HOH A . 
E 3 HOH 6   506 29  HOH HOH A . 
E 3 HOH 7   507 66  HOH HOH A . 
E 3 HOH 8   508 65  HOH HOH A . 
E 3 HOH 9   509 27  HOH HOH A . 
E 3 HOH 10  510 129 HOH HOH A . 
E 3 HOH 11  511 189 HOH HOH A . 
E 3 HOH 12  512 81  HOH HOH A . 
E 3 HOH 13  513 40  HOH HOH A . 
E 3 HOH 14  514 157 HOH HOH A . 
E 3 HOH 15  515 37  HOH HOH A . 
E 3 HOH 16  516 230 HOH HOH A . 
E 3 HOH 17  517 223 HOH HOH A . 
E 3 HOH 18  518 179 HOH HOH A . 
E 3 HOH 19  519 178 HOH HOH A . 
E 3 HOH 20  520 17  HOH HOH A . 
E 3 HOH 21  521 149 HOH HOH A . 
E 3 HOH 22  522 138 HOH HOH A . 
E 3 HOH 23  523 33  HOH HOH A . 
E 3 HOH 24  524 75  HOH HOH A . 
E 3 HOH 25  525 106 HOH HOH A . 
E 3 HOH 26  526 211 HOH HOH A . 
E 3 HOH 27  527 26  HOH HOH A . 
E 3 HOH 28  528 84  HOH HOH A . 
E 3 HOH 29  529 44  HOH HOH A . 
E 3 HOH 30  530 123 HOH HOH A . 
E 3 HOH 31  531 175 HOH HOH A . 
E 3 HOH 32  532 210 HOH HOH A . 
E 3 HOH 33  533 119 HOH HOH A . 
E 3 HOH 34  534 228 HOH HOH A . 
E 3 HOH 35  535 203 HOH HOH A . 
E 3 HOH 36  536 11  HOH HOH A . 
E 3 HOH 37  537 145 HOH HOH A . 
E 3 HOH 38  538 52  HOH HOH A . 
E 3 HOH 39  539 200 HOH HOH A . 
E 3 HOH 40  540 153 HOH HOH A . 
E 3 HOH 41  541 108 HOH HOH A . 
E 3 HOH 42  542 169 HOH HOH A . 
E 3 HOH 43  543 28  HOH HOH A . 
E 3 HOH 44  544 141 HOH HOH A . 
E 3 HOH 45  545 124 HOH HOH A . 
E 3 HOH 46  546 62  HOH HOH A . 
E 3 HOH 47  547 87  HOH HOH A . 
E 3 HOH 48  548 120 HOH HOH A . 
E 3 HOH 49  549 98  HOH HOH A . 
E 3 HOH 50  550 71  HOH HOH A . 
E 3 HOH 51  551 112 HOH HOH A . 
E 3 HOH 52  552 67  HOH HOH A . 
E 3 HOH 53  553 53  HOH HOH A . 
E 3 HOH 54  554 21  HOH HOH A . 
E 3 HOH 55  555 156 HOH HOH A . 
E 3 HOH 56  556 192 HOH HOH A . 
E 3 HOH 57  557 38  HOH HOH A . 
E 3 HOH 58  558 221 HOH HOH A . 
E 3 HOH 59  559 54  HOH HOH A . 
E 3 HOH 60  560 109 HOH HOH A . 
E 3 HOH 61  561 56  HOH HOH A . 
E 3 HOH 62  562 176 HOH HOH A . 
E 3 HOH 63  563 227 HOH HOH A . 
E 3 HOH 64  564 199 HOH HOH A . 
E 3 HOH 65  565 60  HOH HOH A . 
E 3 HOH 66  566 148 HOH HOH A . 
E 3 HOH 67  567 218 HOH HOH A . 
E 3 HOH 68  568 90  HOH HOH A . 
E 3 HOH 69  569 42  HOH HOH A . 
E 3 HOH 70  570 49  HOH HOH A . 
E 3 HOH 71  571 188 HOH HOH A . 
E 3 HOH 72  572 164 HOH HOH A . 
E 3 HOH 73  573 150 HOH HOH A . 
E 3 HOH 74  574 103 HOH HOH A . 
E 3 HOH 75  575 43  HOH HOH A . 
E 3 HOH 76  576 215 HOH HOH A . 
E 3 HOH 77  577 167 HOH HOH A . 
E 3 HOH 78  578 18  HOH HOH A . 
E 3 HOH 79  579 131 HOH HOH A . 
E 3 HOH 80  580 51  HOH HOH A . 
E 3 HOH 81  581 1   HOH HOH A . 
E 3 HOH 82  582 171 HOH HOH A . 
E 3 HOH 83  583 154 HOH HOH A . 
E 3 HOH 84  584 136 HOH HOH A . 
E 3 HOH 85  585 118 HOH HOH A . 
E 3 HOH 86  586 16  HOH HOH A . 
E 3 HOH 87  587 205 HOH HOH A . 
E 3 HOH 88  588 59  HOH HOH A . 
E 3 HOH 89  589 113 HOH HOH A . 
E 3 HOH 90  590 234 HOH HOH A . 
E 3 HOH 91  591 158 HOH HOH A . 
E 3 HOH 92  592 20  HOH HOH A . 
E 3 HOH 93  593 196 HOH HOH A . 
E 3 HOH 94  594 186 HOH HOH A . 
E 3 HOH 95  595 73  HOH HOH A . 
E 3 HOH 96  596 213 HOH HOH A . 
E 3 HOH 97  597 195 HOH HOH A . 
E 3 HOH 98  598 146 HOH HOH A . 
E 3 HOH 99  599 204 HOH HOH A . 
E 3 HOH 100 600 159 HOH HOH A . 
E 3 HOH 101 601 152 HOH HOH A . 
E 3 HOH 102 602 180 HOH HOH A . 
E 3 HOH 103 603 143 HOH HOH A . 
E 3 HOH 104 604 111 HOH HOH A . 
E 3 HOH 105 605 139 HOH HOH A . 
E 3 HOH 106 606 125 HOH HOH A . 
E 3 HOH 107 607 173 HOH HOH A . 
E 3 HOH 108 608 224 HOH HOH A . 
F 3 HOH 1   501 122 HOH HOH B . 
F 3 HOH 2   502 222 HOH HOH B . 
F 3 HOH 3   503 219 HOH HOH B . 
F 3 HOH 4   504 161 HOH HOH B . 
F 3 HOH 5   505 89  HOH HOH B . 
F 3 HOH 6   506 202 HOH HOH B . 
F 3 HOH 7   507 30  HOH HOH B . 
F 3 HOH 8   508 198 HOH HOH B . 
F 3 HOH 9   509 121 HOH HOH B . 
F 3 HOH 10  510 41  HOH HOH B . 
F 3 HOH 11  511 184 HOH HOH B . 
F 3 HOH 12  512 70  HOH HOH B . 
F 3 HOH 13  513 126 HOH HOH B . 
F 3 HOH 14  514 206 HOH HOH B . 
F 3 HOH 15  515 212 HOH HOH B . 
F 3 HOH 16  516 36  HOH HOH B . 
F 3 HOH 17  517 78  HOH HOH B . 
F 3 HOH 18  518 133 HOH HOH B . 
F 3 HOH 19  519 68  HOH HOH B . 
F 3 HOH 20  520 101 HOH HOH B . 
F 3 HOH 21  521 7   HOH HOH B . 
F 3 HOH 22  522 151 HOH HOH B . 
F 3 HOH 23  523 83  HOH HOH B . 
F 3 HOH 24  524 130 HOH HOH B . 
F 3 HOH 25  525 10  HOH HOH B . 
F 3 HOH 26  526 201 HOH HOH B . 
F 3 HOH 27  527 23  HOH HOH B . 
F 3 HOH 28  528 92  HOH HOH B . 
F 3 HOH 29  529 19  HOH HOH B . 
F 3 HOH 30  530 177 HOH HOH B . 
F 3 HOH 31  531 85  HOH HOH B . 
F 3 HOH 32  532 8   HOH HOH B . 
F 3 HOH 33  533 88  HOH HOH B . 
F 3 HOH 34  534 160 HOH HOH B . 
F 3 HOH 35  535 12  HOH HOH B . 
F 3 HOH 36  536 72  HOH HOH B . 
F 3 HOH 37  537 105 HOH HOH B . 
F 3 HOH 38  538 35  HOH HOH B . 
F 3 HOH 39  539 97  HOH HOH B . 
F 3 HOH 40  540 25  HOH HOH B . 
F 3 HOH 41  541 58  HOH HOH B . 
F 3 HOH 42  542 137 HOH HOH B . 
F 3 HOH 43  543 225 HOH HOH B . 
F 3 HOH 44  544 162 HOH HOH B . 
F 3 HOH 45  545 24  HOH HOH B . 
F 3 HOH 46  546 55  HOH HOH B . 
F 3 HOH 47  547 115 HOH HOH B . 
F 3 HOH 48  548 14  HOH HOH B . 
F 3 HOH 49  549 9   HOH HOH B . 
F 3 HOH 50  550 34  HOH HOH B . 
F 3 HOH 51  551 168 HOH HOH B . 
F 3 HOH 52  552 226 HOH HOH B . 
F 3 HOH 53  553 46  HOH HOH B . 
F 3 HOH 54  554 31  HOH HOH B . 
F 3 HOH 55  555 50  HOH HOH B . 
F 3 HOH 56  556 231 HOH HOH B . 
F 3 HOH 57  557 110 HOH HOH B . 
F 3 HOH 58  558 86  HOH HOH B . 
F 3 HOH 59  559 93  HOH HOH B . 
F 3 HOH 60  560 102 HOH HOH B . 
F 3 HOH 61  561 94  HOH HOH B . 
F 3 HOH 62  562 22  HOH HOH B . 
F 3 HOH 63  563 15  HOH HOH B . 
F 3 HOH 64  564 48  HOH HOH B . 
F 3 HOH 65  565 132 HOH HOH B . 
F 3 HOH 66  566 165 HOH HOH B . 
F 3 HOH 67  567 155 HOH HOH B . 
F 3 HOH 68  568 82  HOH HOH B . 
F 3 HOH 69  569 127 HOH HOH B . 
F 3 HOH 70  570 2   HOH HOH B . 
F 3 HOH 71  571 61  HOH HOH B . 
F 3 HOH 72  572 4   HOH HOH B . 
F 3 HOH 73  573 63  HOH HOH B . 
F 3 HOH 74  574 142 HOH HOH B . 
F 3 HOH 75  575 3   HOH HOH B . 
F 3 HOH 76  576 6   HOH HOH B . 
F 3 HOH 77  577 32  HOH HOH B . 
F 3 HOH 78  578 76  HOH HOH B . 
F 3 HOH 79  579 116 HOH HOH B . 
F 3 HOH 80  580 232 HOH HOH B . 
F 3 HOH 81  581 185 HOH HOH B . 
F 3 HOH 82  582 45  HOH HOH B . 
F 3 HOH 83  583 172 HOH HOH B . 
F 3 HOH 84  584 100 HOH HOH B . 
F 3 HOH 85  585 166 HOH HOH B . 
F 3 HOH 86  586 128 HOH HOH B . 
F 3 HOH 87  587 229 HOH HOH B . 
F 3 HOH 88  588 216 HOH HOH B . 
F 3 HOH 89  589 80  HOH HOH B . 
F 3 HOH 90  590 190 HOH HOH B . 
F 3 HOH 91  591 57  HOH HOH B . 
F 3 HOH 92  592 39  HOH HOH B . 
F 3 HOH 93  593 147 HOH HOH B . 
F 3 HOH 94  594 174 HOH HOH B . 
F 3 HOH 95  595 144 HOH HOH B . 
F 3 HOH 96  596 107 HOH HOH B . 
F 3 HOH 97  597 209 HOH HOH B . 
F 3 HOH 98  598 5   HOH HOH B . 
F 3 HOH 99  599 233 HOH HOH B . 
F 3 HOH 100 600 91  HOH HOH B . 
F 3 HOH 101 601 13  HOH HOH B . 
F 3 HOH 102 602 220 HOH HOH B . 
F 3 HOH 103 603 170 HOH HOH B . 
F 3 HOH 104 604 163 HOH HOH B . 
F 3 HOH 105 605 77  HOH HOH B . 
F 3 HOH 106 606 191 HOH HOH B . 
F 3 HOH 107 607 96  HOH HOH B . 
F 3 HOH 108 608 208 HOH HOH B . 
F 3 HOH 109 609 182 HOH HOH B . 
F 3 HOH 110 610 74  HOH HOH B . 
F 3 HOH 111 611 99  HOH HOH B . 
F 3 HOH 112 612 217 HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1   1 Y 1 A SER 46  ? OG  ? A SER 46  OG  
2   1 Y 1 A GLU 47  ? CG  ? A GLU 47  CG  
3   1 Y 1 A GLU 47  ? CD  ? A GLU 47  CD  
4   1 Y 1 A GLU 47  ? OE1 ? A GLU 47  OE1 
5   1 Y 1 A GLU 47  ? OE2 ? A GLU 47  OE2 
6   1 Y 1 A LEU 50  ? CG  ? A LEU 50  CG  
7   1 Y 1 A LEU 50  ? CD1 ? A LEU 50  CD1 
8   1 Y 1 A LEU 50  ? CD2 ? A LEU 50  CD2 
9   1 Y 1 A LEU 67  ? CG  ? A LEU 67  CG  
10  1 Y 1 A LEU 67  ? CD1 ? A LEU 67  CD1 
11  1 Y 1 A LEU 67  ? CD2 ? A LEU 67  CD2 
12  1 Y 1 A GLN 69  ? CG  ? A GLN 69  CG  
13  1 Y 1 A GLN 69  ? CD  ? A GLN 69  CD  
14  1 Y 1 A GLN 69  ? OE1 ? A GLN 69  OE1 
15  1 Y 1 A GLN 69  ? NE2 ? A GLN 69  NE2 
16  1 Y 1 A ASN 72  ? CG  ? A ASN 72  CG  
17  1 Y 1 A ASN 72  ? OD1 ? A ASN 72  OD1 
18  1 Y 1 A ASN 72  ? ND2 ? A ASN 72  ND2 
19  1 Y 1 A GLN 74  ? CG  ? A GLN 74  CG  
20  1 Y 1 A GLN 74  ? CD  ? A GLN 74  CD  
21  1 Y 1 A GLN 74  ? OE1 ? A GLN 74  OE1 
22  1 Y 1 A GLN 74  ? NE2 ? A GLN 74  NE2 
23  1 Y 1 A ARG 76  ? CG  ? A ARG 76  CG  
24  1 Y 1 A ARG 76  ? CD  ? A ARG 76  CD  
25  1 Y 1 A ARG 76  ? NE  ? A ARG 76  NE  
26  1 Y 1 A ARG 76  ? CZ  ? A ARG 76  CZ  
27  1 Y 1 A ARG 76  ? NH1 ? A ARG 76  NH1 
28  1 Y 1 A ARG 76  ? NH2 ? A ARG 76  NH2 
29  1 Y 1 A LYS 90  ? CE  ? A LYS 90  CE  
30  1 Y 1 A LYS 90  ? NZ  ? A LYS 90  NZ  
31  1 Y 1 A LYS 100 ? CD  ? A LYS 100 CD  
32  1 Y 1 A LYS 100 ? CE  ? A LYS 100 CE  
33  1 Y 1 A LYS 100 ? NZ  ? A LYS 100 NZ  
34  1 Y 1 A LYS 102 ? CD  ? A LYS 102 CD  
35  1 Y 1 A LYS 102 ? CE  ? A LYS 102 CE  
36  1 Y 1 A LYS 102 ? NZ  ? A LYS 102 NZ  
37  1 Y 1 A LYS 137 ? CD  ? A LYS 137 CD  
38  1 Y 1 A LYS 137 ? CE  ? A LYS 137 CE  
39  1 Y 1 A LYS 137 ? NZ  ? A LYS 137 NZ  
40  1 Y 1 A TYR 154 ? CG  ? A TYR 154 CG  
41  1 Y 1 A TYR 154 ? CD1 ? A TYR 154 CD1 
42  1 Y 1 A TYR 154 ? CD2 ? A TYR 154 CD2 
43  1 Y 1 A TYR 154 ? CE1 ? A TYR 154 CE1 
44  1 Y 1 A TYR 154 ? CE2 ? A TYR 154 CE2 
45  1 Y 1 A TYR 154 ? CZ  ? A TYR 154 CZ  
46  1 Y 1 A TYR 154 ? OH  ? A TYR 154 OH  
47  1 Y 1 A ASP 155 ? CG  ? A ASP 155 CG  
48  1 Y 1 A ASP 155 ? OD1 ? A ASP 155 OD1 
49  1 Y 1 A ASP 155 ? OD2 ? A ASP 155 OD2 
50  1 Y 1 A ASN 228 ? CG  ? A ASN 228 CG  
51  1 Y 1 A ASN 228 ? OD1 ? A ASN 228 OD1 
52  1 Y 1 A ASN 228 ? ND2 ? A ASN 228 ND2 
53  1 Y 1 A MET 235 ? CG  ? A MET 235 CG  
54  1 Y 1 A MET 235 ? SD  ? A MET 235 SD  
55  1 Y 1 A MET 235 ? CE  ? A MET 235 CE  
56  1 Y 1 A ASN 277 ? CG  ? A ASN 277 CG  
57  1 Y 1 A ASN 277 ? OD1 ? A ASN 277 OD1 
58  1 Y 1 A ASN 277 ? ND2 ? A ASN 277 ND2 
59  1 Y 1 A ARG 279 ? NE  ? A ARG 279 NE  
60  1 Y 1 A ARG 279 ? CZ  ? A ARG 279 CZ  
61  1 Y 1 A ARG 279 ? NH1 ? A ARG 279 NH1 
62  1 Y 1 A ARG 279 ? NH2 ? A ARG 279 NH2 
63  1 Y 1 A SER 301 ? OG  ? A SER 301 OG  
64  1 Y 1 B SER 46  ? OG  ? B SER 46  OG  
65  1 Y 1 B GLU 47  ? CG  ? B GLU 47  CG  
66  1 Y 1 B GLU 47  ? CD  ? B GLU 47  CD  
67  1 Y 1 B GLU 47  ? OE1 ? B GLU 47  OE1 
68  1 Y 1 B GLU 47  ? OE2 ? B GLU 47  OE2 
69  1 Y 1 B LEU 50  ? CG  ? B LEU 50  CG  
70  1 Y 1 B LEU 50  ? CD1 ? B LEU 50  CD1 
71  1 Y 1 B LEU 50  ? CD2 ? B LEU 50  CD2 
72  1 Y 1 B LEU 67  ? CG  ? B LEU 67  CG  
73  1 Y 1 B LEU 67  ? CD1 ? B LEU 67  CD1 
74  1 Y 1 B LEU 67  ? CD2 ? B LEU 67  CD2 
75  1 Y 1 B GLN 69  ? CD  ? B GLN 69  CD  
76  1 Y 1 B GLN 69  ? OE1 ? B GLN 69  OE1 
77  1 Y 1 B GLN 69  ? NE2 ? B GLN 69  NE2 
78  1 Y 1 B ASN 72  ? CG  ? B ASN 72  CG  
79  1 Y 1 B ASN 72  ? OD1 ? B ASN 72  OD1 
80  1 Y 1 B ASN 72  ? ND2 ? B ASN 72  ND2 
81  1 Y 1 B GLN 74  ? CG  ? B GLN 74  CG  
82  1 Y 1 B GLN 74  ? CD  ? B GLN 74  CD  
83  1 Y 1 B GLN 74  ? OE1 ? B GLN 74  OE1 
84  1 Y 1 B GLN 74  ? NE2 ? B GLN 74  NE2 
85  1 Y 1 B ARG 76  ? CG  ? B ARG 76  CG  
86  1 Y 1 B ARG 76  ? CD  ? B ARG 76  CD  
87  1 Y 1 B ARG 76  ? NE  ? B ARG 76  NE  
88  1 Y 1 B ARG 76  ? CZ  ? B ARG 76  CZ  
89  1 Y 1 B ARG 76  ? NH1 ? B ARG 76  NH1 
90  1 Y 1 B ARG 76  ? NH2 ? B ARG 76  NH2 
91  1 Y 1 B LYS 90  ? CE  ? B LYS 90  CE  
92  1 Y 1 B LYS 90  ? NZ  ? B LYS 90  NZ  
93  1 Y 1 B LYS 100 ? CG  ? B LYS 100 CG  
94  1 Y 1 B LYS 100 ? CD  ? B LYS 100 CD  
95  1 Y 1 B LYS 100 ? CE  ? B LYS 100 CE  
96  1 Y 1 B LYS 100 ? NZ  ? B LYS 100 NZ  
97  1 Y 1 B LYS 102 ? CD  ? B LYS 102 CD  
98  1 Y 1 B LYS 102 ? CE  ? B LYS 102 CE  
99  1 Y 1 B LYS 102 ? NZ  ? B LYS 102 NZ  
100 1 Y 1 B TYR 154 ? CG  ? B TYR 154 CG  
101 1 Y 1 B TYR 154 ? CD1 ? B TYR 154 CD1 
102 1 Y 1 B TYR 154 ? CD2 ? B TYR 154 CD2 
103 1 Y 1 B TYR 154 ? CE1 ? B TYR 154 CE1 
104 1 Y 1 B TYR 154 ? CE2 ? B TYR 154 CE2 
105 1 Y 1 B TYR 154 ? CZ  ? B TYR 154 CZ  
106 1 Y 1 B TYR 154 ? OH  ? B TYR 154 OH  
107 1 Y 1 B ASP 155 ? CG  ? B ASP 155 CG  
108 1 Y 1 B ASP 155 ? OD1 ? B ASP 155 OD1 
109 1 Y 1 B ASP 155 ? OD2 ? B ASP 155 OD2 
110 1 Y 1 B ARG 188 ? CG  ? B ARG 188 CG  
111 1 Y 1 B ARG 188 ? CD  ? B ARG 188 CD  
112 1 Y 1 B ARG 188 ? NE  ? B ARG 188 NE  
113 1 Y 1 B ARG 188 ? CZ  ? B ARG 188 CZ  
114 1 Y 1 B ARG 188 ? NH1 ? B ARG 188 NH1 
115 1 Y 1 B ARG 188 ? NH2 ? B ARG 188 NH2 
116 1 Y 1 B ARG 222 ? CG  ? B ARG 222 CG  
117 1 Y 1 B ARG 222 ? CD  ? B ARG 222 CD  
118 1 Y 1 B ARG 222 ? NE  ? B ARG 222 NE  
119 1 Y 1 B ARG 222 ? CZ  ? B ARG 222 CZ  
120 1 Y 1 B ARG 222 ? NH1 ? B ARG 222 NH1 
121 1 Y 1 B ARG 222 ? NH2 ? B ARG 222 NH2 
122 1 Y 1 B MET 235 ? CG  ? B MET 235 CG  
123 1 Y 1 B MET 235 ? SD  ? B MET 235 SD  
124 1 Y 1 B MET 235 ? CE  ? B MET 235 CE  
125 1 Y 1 B LYS 236 ? CD  ? B LYS 236 CD  
126 1 Y 1 B LYS 236 ? CE  ? B LYS 236 CE  
127 1 Y 1 B LYS 236 ? NZ  ? B LYS 236 NZ  
128 1 Y 1 B GLU 270 ? CG  ? B GLU 270 CG  
129 1 Y 1 B GLU 270 ? CD  ? B GLU 270 CD  
130 1 Y 1 B GLU 270 ? OE1 ? B GLU 270 OE1 
131 1 Y 1 B GLU 270 ? OE2 ? B GLU 270 OE2 
132 1 Y 1 B ASN 277 ? CG  ? B ASN 277 CG  
133 1 Y 1 B ASN 277 ? OD1 ? B ASN 277 OD1 
134 1 Y 1 B ASN 277 ? ND2 ? B ASN 277 ND2 
135 1 Y 1 B SER 301 ? OG  ? B SER 301 OG  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           4 
# 
_cell.angle_alpha                  90.872 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   109.392 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  108.270 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BO9 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     53.720 
_cell.length_a_esd                 ? 
_cell.length_b                     61.780 
_cell.length_b_esd                 ? 
_cell.length_c                     68.049 
_cell.length_c_esd                 ? 
_cell.volume                       200488.780 
_cell.volume_esd                   ? 
_cell.Z_PDB                        2 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BO9 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            'P 1' 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BO9 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.96 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          58.48 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.0 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M Imidazole, 12% w/v Polyethylene glycol 20,000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            294 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-11-09 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.920112 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSLS-II BEAMLINE 17-ID-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.920112 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   17-ID-1 
_diffrn_source.pdbx_synchrotron_site       NSLS-II 
# 
_reflns.B_iso_Wilson_estimate                          42.34 
_reflns.entry_id                                       9BO9 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.98 
_reflns.d_resolution_low                               29.67 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     52496 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           96.98 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3.5 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          8.95 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.997 
_reflns.pdbx_CC_star                                   0.999 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.06865 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.98 
_reflns_shell.d_res_low                                     2.054 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           0.85 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             4871 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               3.0 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.515 
_reflns_shell.pdbx_CC_star                                  0.824 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          90.41 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.17 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               49.05 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9BO9 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.98 
_refine.ls_d_res_low                             29.67 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     52204 
_refine.ls_number_reflns_R_free                  2568 
_refine.ls_number_reflns_R_work                  49636 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    97.01 
_refine.ls_percent_reflns_R_free                 4.92 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2036 
_refine.ls_R_factor_R_free                       0.2395 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2017 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.96 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 31.2581 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2947 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.98 
_refine_hist.d_res_low                        29.67 
_refine_hist.number_atoms_solvent             220 
_refine_hist.number_atoms_total               4803 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4525 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         58 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0074  ? 4710 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.8527  ? 6424 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0489  ? 737  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0066  ? 835  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 13.0554 ? 1630 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.98 2.02  . . 111 2444 87.47 . . . . 0.3766 . . . . . . . . . . . 0.4029 
'X-RAY DIFFRACTION' 2.02 2.06  . . 142 2763 94.29 . . . . 0.3377 . . . . . . . . . . . 0.3722 
'X-RAY DIFFRACTION' 2.06 2.11  . . 137 2675 96.20 . . . . 0.3137 . . . . . . . . . . . 0.3616 
'X-RAY DIFFRACTION' 2.11 2.16  . . 138 2800 96.61 . . . . 0.2854 . . . . . . . . . . . 0.3082 
'X-RAY DIFFRACTION' 2.16 2.21  . . 141 2769 97.26 . . . . 0.2689 . . . . . . . . . . . 0.3327 
'X-RAY DIFFRACTION' 2.21 2.27  . . 137 2749 97.30 . . . . 0.2802 . . . . . . . . . . . 0.3410 
'X-RAY DIFFRACTION' 2.27 2.34  . . 163 2782 97.84 . . . . 0.2596 . . . . . . . . . . . 0.3293 
'X-RAY DIFFRACTION' 2.34 2.41  . . 156 2745 97.74 . . . . 0.2482 . . . . . . . . . . . 0.3156 
'X-RAY DIFFRACTION' 2.41 2.50  . . 160 2754 97.79 . . . . 0.2423 . . . . . . . . . . . 0.2861 
'X-RAY DIFFRACTION' 2.50 2.60  . . 132 2796 97.99 . . . . 0.2355 . . . . . . . . . . . 0.2793 
'X-RAY DIFFRACTION' 2.60 2.72  . . 139 2815 97.94 . . . . 0.2451 . . . . . . . . . . . 0.3157 
'X-RAY DIFFRACTION' 2.72 2.86  . . 144 2802 98.33 . . . . 0.2414 . . . . . . . . . . . 0.3078 
'X-RAY DIFFRACTION' 2.86 3.04  . . 147 2769 98.08 . . . . 0.2318 . . . . . . . . . . . 0.2893 
'X-RAY DIFFRACTION' 3.04 3.27  . . 149 2798 98.27 . . . . 0.2303 . . . . . . . . . . . 0.2917 
'X-RAY DIFFRACTION' 3.27 3.60  . . 140 2808 98.53 . . . . 0.2012 . . . . . . . . . . . 0.2271 
'X-RAY DIFFRACTION' 3.60 4.12  . . 159 2777 98.26 . . . . 0.1743 . . . . . . . . . . . 0.2021 
'X-RAY DIFFRACTION' 4.12 5.19  . . 124 2807 97.86 . . . . 0.1446 . . . . . . . . . . . 0.1681 
'X-RAY DIFFRACTION' 5.19 29.67 . . 149 2783 98.32 . . . . 0.1508 . . . . . . . . . . . 0.1662 
# 
_struct.entry_id                     9BO9 
_struct.title                        'Crystal Structure of T190I SARS-CoV-2 Main Protease in Complex with GC376' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BO9 
_struct_keywords.text            'Hydrolase, VIRAL PROTEIN' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
E N N 3 ? 
F N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1AB_SARS2 
_struct_ref.pdbx_db_accession          P0DTD1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_struct_ref.pdbx_align_begin           3264 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9BO9 A 1 ? 306 ? P0DTD1 3264 ? 3569 ? 1 306 
2 1 9BO9 B 1 ? 306 ? P0DTD1 3264 ? 3569 ? 1 306 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9BO9 ILE A 190 ? UNP P0DTD1 THR 3453 conflict 190 1 
2 9BO9 ILE B 190 ? UNP P0DTD1 THR 3453 conflict 190 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2580  ? 
1 MORE         -11   ? 
1 'SSA (A^2)'  24030 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 10  ? GLY A 15  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 41  ? CYS A 44  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 GLU A 47  ? ASN A 51  ? GLU A 47  ASN A 51  5 ? 5  
HELX_P HELX_P4  AA4 ASN A 53  ? ARG A 60  ? ASN A 53  ARG A 60  1 ? 8  
HELX_P HELX_P5  AA5 SER A 62  ? HIS A 64  ? SER A 62  HIS A 64  5 ? 3  
HELX_P HELX_P6  AA6 ILE A 200 ? ASN A 214 ? ILE A 200 ASN A 214 1 ? 15 
HELX_P HELX_P7  AA7 THR A 226 ? TYR A 237 ? THR A 226 TYR A 237 1 ? 12 
HELX_P HELX_P8  AA8 THR A 243 ? LEU A 250 ? THR A 243 LEU A 250 1 ? 8  
HELX_P HELX_P9  AA9 LEU A 250 ? GLY A 258 ? LEU A 250 GLY A 258 1 ? 9  
HELX_P HELX_P10 AB1 ALA A 260 ? GLY A 275 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P11 AB2 THR A 292 ? SER A 301 ? THR A 292 SER A 301 1 ? 10 
HELX_P HELX_P12 AB3 SER B 10  ? GLY B 15  ? SER B 10  GLY B 15  1 ? 6  
HELX_P HELX_P13 AB4 HIS B 41  ? CYS B 44  ? HIS B 41  CYS B 44  5 ? 4  
HELX_P HELX_P14 AB5 SER B 46  ? ASN B 51  ? SER B 46  ASN B 51  5 ? 6  
HELX_P HELX_P15 AB6 ASN B 53  ? ARG B 60  ? ASN B 53  ARG B 60  1 ? 8  
HELX_P HELX_P16 AB7 SER B 62  ? PHE B 66  ? SER B 62  PHE B 66  5 ? 5  
HELX_P HELX_P17 AB8 ILE B 200 ? ASN B 214 ? ILE B 200 ASN B 214 1 ? 15 
HELX_P HELX_P18 AB9 THR B 226 ? TYR B 237 ? THR B 226 TYR B 237 1 ? 12 
HELX_P HELX_P19 AC1 THR B 243 ? LEU B 250 ? THR B 243 LEU B 250 1 ? 8  
HELX_P HELX_P20 AC2 LEU B 250 ? GLY B 258 ? LEU B 250 GLY B 258 1 ? 9  
HELX_P HELX_P21 AC3 ALA B 260 ? GLY B 275 ? ALA B 260 GLY B 275 1 ? 16 
HELX_P HELX_P22 AC4 THR B 292 ? CYS B 300 ? THR B 292 CYS B 300 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1 covale one ? A CYS 145 SG ? ? ? 1_555 C UED . C21 ? ? A CYS 145 A UED 401 1_555 ? ? ? ? ? ? ? 1.767 ? ? 
covale2 covale one ? B CYS 145 SG ? ? ? 1_555 D UED . C21 ? ? B CYS 145 B UED 401 1_555 ? ? ? ? ? ? ? 1.765 ? ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 UED C . ? CYS A 145 ? UED A 401 ? 1_555 CYS A 145 ? 1_555 C21 SG CYS 1 UED None 'Covalent chemical modification' 
2 UED D . ? CYS B 145 ? UED B 401 ? 1_555 CYS B 145 ? 1_555 C21 SG CYS 1 UED None 'Covalent chemical modification' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
AA4 ? 7 ? 
AA5 ? 5 ? 
AA6 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA4 5 6 ? anti-parallel 
AA4 6 7 ? anti-parallel 
AA5 1 2 ? parallel      
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA5 4 5 ? anti-parallel 
AA6 1 2 ? parallel      
AA6 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 73  ? LEU A 75  ? VAL A 73  LEU A 75  
AA1 2 PHE A 66  ? ALA A 70  ? PHE A 66  ALA A 70  
AA1 3 MET A 17  ? CYS A 22  ? MET A 17  CYS A 22  
AA1 4 THR A 25  ? LEU A 32  ? THR A 25  LEU A 32  
AA1 5 VAL A 35  ? PRO A 39  ? VAL A 35  PRO A 39  
AA1 6 VAL A 86  ? VAL A 91  ? VAL A 86  VAL A 91  
AA1 7 VAL A 77  ? GLN A 83  ? VAL A 77  GLN A 83  
AA2 1 TYR A 101 ? PHE A 103 ? TYR A 101 PHE A 103 
AA2 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA2 3 VAL A 148 ? ASP A 153 ? VAL A 148 ASP A 153 
AA2 4 THR A 111 ? TYR A 118 ? THR A 111 TYR A 118 
AA2 5 SER A 121 ? ALA A 129 ? SER A 121 ALA A 129 
AA3 1 TYR A 101 ? PHE A 103 ? TYR A 101 PHE A 103 
AA3 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA3 3 HIS A 172 ? THR A 175 ? HIS A 172 THR A 175 
AA4 1 VAL B 73  ? LEU B 75  ? VAL B 73  LEU B 75  
AA4 2 LEU B 67  ? ALA B 70  ? LEU B 67  ALA B 70  
AA4 3 MET B 17  ? CYS B 22  ? MET B 17  CYS B 22  
AA4 4 THR B 25  ? LEU B 32  ? THR B 25  LEU B 32  
AA4 5 VAL B 35  ? PRO B 39  ? VAL B 35  PRO B 39  
AA4 6 VAL B 86  ? VAL B 91  ? VAL B 86  VAL B 91  
AA4 7 VAL B 77  ? GLN B 83  ? VAL B 77  GLN B 83  
AA5 1 TYR B 101 ? PHE B 103 ? TYR B 101 PHE B 103 
AA5 2 CYS B 156 ? GLU B 166 ? CYS B 156 GLU B 166 
AA5 3 VAL B 148 ? ASP B 153 ? VAL B 148 ASP B 153 
AA5 4 THR B 111 ? TYR B 118 ? THR B 111 TYR B 118 
AA5 5 SER B 121 ? ALA B 129 ? SER B 121 ALA B 129 
AA6 1 TYR B 101 ? PHE B 103 ? TYR B 101 PHE B 103 
AA6 2 CYS B 156 ? GLU B 166 ? CYS B 156 GLU B 166 
AA6 3 HIS B 172 ? THR B 175 ? HIS B 172 THR B 175 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O LEU A 75  ? O LEU A 75  N VAL A 68  ? N VAL A 68  
AA1 2 3 O LEU A 67  ? O LEU A 67  N THR A 21  ? N THR A 21  
AA1 3 4 N VAL A 20  ? N VAL A 20  O LEU A 27  ? O LEU A 27  
AA1 4 5 N LEU A 30  ? N LEU A 30  O TYR A 37  ? O TYR A 37  
AA1 5 6 N CYS A 38  ? N CYS A 38  O LEU A 87  ? O LEU A 87  
AA1 6 7 O VAL A 86  ? O VAL A 86  N GLN A 83  ? N GLN A 83  
AA2 1 2 N LYS A 102 ? N LYS A 102 O PHE A 159 ? O PHE A 159 
AA2 2 3 O SER A 158 ? O SER A 158 N ASN A 151 ? N ASN A 151 
AA2 3 4 O PHE A 150 ? O PHE A 150 N SER A 113 ? N SER A 113 
AA2 4 5 N ALA A 116 ? N ALA A 116 O SER A 123 ? O SER A 123 
AA3 1 2 N LYS A 102 ? N LYS A 102 O PHE A 159 ? O PHE A 159 
AA3 2 3 N MET A 165 ? N MET A 165 O ALA A 173 ? O ALA A 173 
AA4 1 2 O VAL B 73  ? O VAL B 73  N ALA B 70  ? N ALA B 70  
AA4 2 3 O LEU B 67  ? O LEU B 67  N THR B 21  ? N THR B 21  
AA4 3 4 N VAL B 20  ? N VAL B 20  O LEU B 27  ? O LEU B 27  
AA4 4 5 N LEU B 30  ? N LEU B 30  O TYR B 37  ? O TYR B 37  
AA4 5 6 N CYS B 38  ? N CYS B 38  O LEU B 87  ? O LEU B 87  
AA4 6 7 O LYS B 90  ? O LYS B 90  N ILE B 78  ? N ILE B 78  
AA5 1 2 N LYS B 102 ? N LYS B 102 O PHE B 159 ? O PHE B 159 
AA5 2 3 O CYS B 156 ? O CYS B 156 N ASP B 153 ? N ASP B 153 
AA5 3 4 O PHE B 150 ? O PHE B 150 N SER B 113 ? N SER B 113 
AA5 4 5 N ALA B 116 ? N ALA B 116 O SER B 123 ? O SER B 123 
AA6 1 2 N LYS B 102 ? N LYS B 102 O PHE B 159 ? O PHE B 159 
AA6 2 3 N MET B 165 ? N MET B 165 O ALA B 173 ? O ALA B 173 
# 
_pdbx_entry_details.entry_id                   9BO9 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ASP A 33  ? ? 59.13   -130.90 
2  1 HIS A 41  ? ? -69.52  2.68    
3  1 ASN A 51  ? ? -160.35 57.03   
4  1 ASN A 84  ? ? 50.67   -127.13 
5  1 TYR A 154 ? ? 55.40   -109.93 
6  1 THR A 225 ? ? -171.10 149.33  
7  1 ASP B 33  ? ? 53.15   -142.01 
8  1 ASP B 34  ? ? -92.67  32.09   
9  1 HIS B 41  ? ? -69.72  5.82    
10 1 ASN B 51  ? ? -164.81 76.05   
11 1 ASN B 84  ? ? 46.92   -116.85 
12 1 TYR B 154 ? ? 54.18   -121.60 
13 1 GLU B 290 ? ? -99.50  30.87   
# 
_pdbx_molecule_features.prd_id    PRD_002495 
_pdbx_molecule_features.name      GC376 
_pdbx_molecule_features.type      Peptide-like 
_pdbx_molecule_features.class     Inhibitor 
_pdbx_molecule_features.details   ? 
# 
loop_
_pdbx_molecule.instance_id 
_pdbx_molecule.prd_id 
_pdbx_molecule.asym_id 
1 PRD_002495 C 
2 PRD_002495 D 
# 
_space_group_symop.id              1 
_space_group_symop.operation_xyz   x,y,z 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 302 ? A GLY 302 
2  1 Y 1 A VAL 303 ? A VAL 303 
3  1 Y 1 A THR 304 ? A THR 304 
4  1 Y 1 A PHE 305 ? A PHE 305 
5  1 Y 1 A GLN 306 ? A GLN 306 
6  1 Y 1 B GLY 302 ? B GLY 302 
7  1 Y 1 B VAL 303 ? B VAL 303 
8  1 Y 1 B THR 304 ? B THR 304 
9  1 Y 1 B PHE 305 ? B PHE 305 
10 1 Y 1 B GLN 306 ? B GLN 306 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
UED C7   C N N 372 
UED O8   O N N 373 
UED C9   C N N 374 
UED O10  O N N 375 
UED C1   C Y N 376 
UED C2   C Y N 377 
UED C3   C Y N 378 
UED C4   C Y N 379 
UED C5   C Y N 380 
UED C6   C Y N 381 
UED N11  N N N 382 
UED C12  C N S 383 
UED C17  C N N 384 
UED O18  O N N 385 
UED C13  C N N 386 
UED C14  C N N 387 
UED C15  C N N 388 
UED C16  C N N 389 
UED N19  N N N 390 
UED C20  C N S 391 
UED C21  C N N 392 
UED O22  O N N 393 
UED C24  C N N 394 
UED C25  C N S 395 
UED C26  C N N 396 
UED C27  C N N 397 
UED N28  N N N 398 
UED C29  C N N 399 
UED O30  O N N 400 
UED H1   H N N 401 
UED H2   H N N 402 
UED H3   H N N 403 
UED H4   H N N 404 
UED H5   H N N 405 
UED H6   H N N 406 
UED H7   H N N 407 
UED H8   H N N 408 
UED H9   H N N 409 
UED H10  H N N 410 
UED H11  H N N 411 
UED H12  H N N 412 
UED H13  H N N 413 
UED H14  H N N 414 
UED H15  H N N 415 
UED H16  H N N 416 
UED H17  H N N 417 
UED H18  H N N 418 
UED H19  H N N 419 
UED H20  H N N 420 
UED H21  H N N 421 
UED H22  H N N 422 
UED H23  H N N 423 
UED H24  H N N 424 
UED H25  H N N 425 
UED H26  H N N 426 
UED H27  H N N 427 
UED H28  H N N 428 
UED H29  H N N 429 
UED H30  H N N 430 
UED H31  H N N 431 
VAL N    N N N 432 
VAL CA   C N S 433 
VAL C    C N N 434 
VAL O    O N N 435 
VAL CB   C N N 436 
VAL CG1  C N N 437 
VAL CG2  C N N 438 
VAL OXT  O N N 439 
VAL H    H N N 440 
VAL H2   H N N 441 
VAL HA   H N N 442 
VAL HB   H N N 443 
VAL HG11 H N N 444 
VAL HG12 H N N 445 
VAL HG13 H N N 446 
VAL HG21 H N N 447 
VAL HG22 H N N 448 
VAL HG23 H N N 449 
VAL HXT  H N N 450 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
UED C16 C14  sing N N 358 
UED C3  C2   doub Y N 359 
UED C3  C4   sing Y N 360 
UED C2  C1   sing Y N 361 
UED C14 C13  sing N N 362 
UED C14 C15  sing N N 363 
UED C13 C12  sing N N 364 
UED C4  C5   doub Y N 365 
UED O8  C7   sing N N 366 
UED O8  C9   sing N N 367 
UED N11 C12  sing N N 368 
UED N11 C9   sing N N 369 
UED C1  C7   sing N N 370 
UED C1  C6   doub Y N 371 
UED O18 C17  doub N N 372 
UED C5  C6   sing Y N 373 
UED C12 C17  sing N N 374 
UED C9  O10  doub N N 375 
UED C17 N19  sing N N 376 
UED C26 C27  sing N N 377 
UED C26 C25  sing N N 378 
UED N19 C20  sing N N 379 
UED C20 C21  sing N N 380 
UED C20 C24  sing N N 381 
UED C27 N28  sing N N 382 
UED O22 C21  sing N N 383 
UED C25 C24  sing N N 384 
UED C25 C29  sing N N 385 
UED N28 C29  sing N N 386 
UED C29 O30  doub N N 387 
UED C7  H1   sing N N 388 
UED C7  H2   sing N N 389 
UED C2  H3   sing N N 390 
UED C3  H4   sing N N 391 
UED C4  H5   sing N N 392 
UED C5  H6   sing N N 393 
UED C6  H7   sing N N 394 
UED N11 H8   sing N N 395 
UED C12 H9   sing N N 396 
UED C13 H10  sing N N 397 
UED C13 H11  sing N N 398 
UED C14 H12  sing N N 399 
UED C15 H13  sing N N 400 
UED C15 H14  sing N N 401 
UED C15 H15  sing N N 402 
UED C16 H16  sing N N 403 
UED C16 H17  sing N N 404 
UED C16 H18  sing N N 405 
UED N19 H19  sing N N 406 
UED C20 H20  sing N N 407 
UED C24 H21  sing N N 408 
UED C24 H22  sing N N 409 
UED C25 H23  sing N N 410 
UED C26 H24  sing N N 411 
UED C26 H25  sing N N 412 
UED C27 H26  sing N N 413 
UED C27 H27  sing N N 414 
UED N28 H28  sing N N 415 
UED C21 H29  sing N N 416 
UED C21 H30  sing N N 417 
UED O22 H31  sing N N 418 
VAL N   CA   sing N N 419 
VAL N   H    sing N N 420 
VAL N   H2   sing N N 421 
VAL CA  C    sing N N 422 
VAL CA  CB   sing N N 423 
VAL CA  HA   sing N N 424 
VAL C   O    doub N N 425 
VAL C   OXT  sing N N 426 
VAL CB  CG1  sing N N 427 
VAL CB  CG2  sing N N 428 
VAL CB  HB   sing N N 429 
VAL CG1 HG11 sing N N 430 
VAL CG1 HG12 sing N N 431 
VAL CG1 HG13 sing N N 432 
VAL CG2 HG21 sing N N 433 
VAL CG2 HG22 sing N N 434 
VAL CG2 HG23 sing N N 435 
VAL OXT HXT  sing N N 436 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' 'P30 GM133893' 1 
'Department of Energy (DOE, United States)'                                                'United States' KP1607011      2 
'Other government'                                                                         ?               DE-SC0012704   3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7U29 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 1' 
_space_group.name_Hall        'P 1' 
_space_group.IT_number        1 
_space_group.crystal_system   triclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9BO9 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.018615 
_atom_sites.fract_transf_matrix[1][2]   0.006146 
_atom_sites.fract_transf_matrix[1][3]   0.007437 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.017046 
_atom_sites.fract_transf_matrix[2][3]   0.002291 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.015719 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . SER A 1 1   ? -34.61362 -22.94978 18.00956  1.000 45.86153 ? 1   SER A N   1 
ATOM   2    C CA  . SER A 1 1   ? -34.40678 -23.25430 16.60180  1.000 46.05875 ? 1   SER A CA  1 
ATOM   3    C C   . SER A 1 1   ? -34.22293 -21.98391 15.74281  1.000 45.80716 ? 1   SER A C   1 
ATOM   4    O O   . SER A 1 1   ? -34.50735 -20.87500 16.20432  1.000 43.03308 ? 1   SER A O   1 
ATOM   5    C CB  . SER A 1 1   ? -35.58007 -24.07926 16.09009  1.000 45.42614 ? 1   SER A CB  1 
ATOM   6    O OG  . SER A 1 1   ? -35.67848 -24.00985 14.68034  1.000 51.52907 ? 1   SER A OG  1 
ATOM   7    N N   . GLY A 1 2   ? -33.78310 -22.16326 14.50142  1.000 41.17960 ? 2   GLY A N   1 
ATOM   8    C CA  . GLY A 1 2   ? -33.52184 -21.10262 13.54140  1.000 46.47915 ? 2   GLY A CA  1 
ATOM   9    C C   . GLY A 1 2   ? -32.03972 -20.77435 13.45658  1.000 40.18267 ? 2   GLY A C   1 
ATOM   10   O O   . GLY A 1 2   ? -31.28033 -20.96506 14.40968  1.000 44.41846 ? 2   GLY A O   1 
ATOM   11   N N   . PHE A 1 3   ? -31.61030 -20.26856 12.29684  1.000 44.42328 ? 3   PHE A N   1 
ATOM   12   C CA  . PHE A 1 3   ? -30.18928 -19.96053 12.09806  1.000 41.36593 ? 3   PHE A CA  1 
ATOM   13   C C   . PHE A 1 3   ? -30.05549 -18.74367 11.19510  1.000 44.87967 ? 3   PHE A C   1 
ATOM   14   O O   . PHE A 1 3   ? -30.40475 -18.80633 10.01386  1.000 48.00672 ? 3   PHE A O   1 
ATOM   15   C CB  . PHE A 1 3   ? -29.43655 -21.15443 11.50865  1.000 43.12345 ? 3   PHE A CB  1 
ATOM   16   C CG  . PHE A 1 3   ? -27.93935 -21.07408 11.69584  1.000 42.63054 ? 3   PHE A CG  1 
ATOM   17   C CD1 . PHE A 1 3   ? -27.36621 -21.37199 12.92330  1.000 39.22957 ? 3   PHE A CD1 1 
ATOM   18   C CD2 . PHE A 1 3   ? -27.10914 -20.66250 10.64594  1.000 41.39902 ? 3   PHE A CD2 1 
ATOM   19   C CE1 . PHE A 1 3   ? -25.99111 -21.28650 13.10394  1.000 41.89449 ? 3   PHE A CE1 1 
ATOM   20   C CE2 . PHE A 1 3   ? -25.72383 -20.57855 10.81520  1.000 37.47169 ? 3   PHE A CE2 1 
ATOM   21   C CZ  . PHE A 1 3   ? -25.16743 -20.89172 12.05601  1.000 40.13621 ? 3   PHE A CZ  1 
ATOM   22   N N   . ARG A 1 4   ? -29.53109 -17.64663 11.73513  1.000 39.83386 ? 4   ARG A N   1 
ATOM   23   C CA  . ARG A 1 4   ? -29.43354 -16.40167 10.99630  1.000 44.66847 ? 4   ARG A CA  1 
ATOM   24   C C   . ARG A 1 4   ? -27.98715 -15.92730 10.94416  1.000 41.39494 ? 4   ARG A C   1 
ATOM   25   O O   . ARG A 1 4   ? -27.18614 -16.21570 11.83615  1.000 40.88715 ? 4   ARG A O   1 
ATOM   26   C CB  . ARG A 1 4   ? -30.28927 -15.30285 11.63012  1.000 43.61527 ? 4   ARG A CB  1 
ATOM   27   C CG  . ARG A 1 4   ? -31.64366 -15.74410 12.09574  1.000 48.71963 ? 4   ARG A CG  1 
ATOM   28   C CD  . ARG A 1 4   ? -32.54668 -15.98582 10.91605  1.000 52.45756 ? 4   ARG A CD  1 
ATOM   29   N NE  . ARG A 1 4   ? -32.27747 -15.02616 9.85308   1.000 50.99165 ? 4   ARG A NE  1 
ATOM   30   C CZ  . ARG A 1 4   ? -33.06732 -14.01093 9.52429   1.000 54.53920 ? 4   ARG A CZ  1 
ATOM   31   N NH1 . ARG A 1 4   ? -34.19481 -13.77438 10.16572  1.000 45.72788 ? 4   ARG A NH1 1 
ATOM   32   N NH2 . ARG A 1 4   ? -32.71639 -13.21632 8.51437   1.000 61.12315 ? 4   ARG A NH2 1 
ATOM   33   N N   . LYS A 1 5   ? -27.66285 -15.17239 9.90425   1.000 43.03226 ? 5   LYS A N   1 
ATOM   34   C CA  . LYS A 1 5   ? -26.39995 -14.44875 9.90901   1.000 42.55054 ? 5   LYS A CA  1 
ATOM   35   C C   . LYS A 1 5   ? -26.50349 -13.36058 10.97171  1.000 38.38702 ? 5   LYS A C   1 
ATOM   36   O O   . LYS A 1 5   ? -27.25318 -12.39397 10.81118  1.000 43.91956 ? 5   LYS A O   1 
ATOM   37   C CB  . LYS A 1 5   ? -26.10689 -13.88128 8.52543   1.000 44.80286 ? 5   LYS A CB  1 
ATOM   38   C CG  . LYS A 1 5   ? -24.64864 -13.52299 8.33320   1.000 45.99909 ? 5   LYS A CG  1 
ATOM   39   C CD  . LYS A 1 5   ? -23.89413 -14.61999 7.61981   1.000 49.20501 ? 5   LYS A CD  1 
ATOM   40   C CE  . LYS A 1 5   ? -24.21355 -14.61837 6.14587   1.000 51.91708 ? 5   LYS A CE  1 
ATOM   41   N NZ  . LYS A 1 5   ? -23.55191 -15.77063 5.49235   1.000 50.17453 ? 5   LYS A NZ  1 
ATOM   42   N N   . MET A 1 6   ? -25.77591 -13.52498 12.06999  1.000 35.35635 ? 6   MET A N   1 
ATOM   43   C CA  . MET A 1 6   ? -25.98663 -12.74948 13.28735  1.000 41.21292 ? 6   MET A CA  1 
ATOM   44   C C   . MET A 1 6   ? -24.74820 -11.94245 13.66099  1.000 36.49284 ? 6   MET A C   1 
ATOM   45   O O   . MET A 1 6   ? -23.66884 -12.50668 13.84138  1.000 39.28825 ? 6   MET A O   1 
ATOM   46   C CB  . MET A 1 6   ? -26.34588 -13.68903 14.43873  1.000 42.61316 ? 6   MET A CB  1 
ATOM   47   C CG  . MET A 1 6   ? -26.46437 -13.03956 15.78714  1.000 46.61895 ? 6   MET A CG  1 
ATOM   48   S SD  . MET A 1 6   ? -27.19125 -14.23326 16.94473  1.000 49.23728 ? 6   MET A SD  1 
ATOM   49   C CE  . MET A 1 6   ? -28.25865 -15.12226 15.82348  1.000 47.87361 ? 6   MET A CE  1 
ATOM   50   N N   . ALA A 1 7   ? -24.92292 -10.64612 13.86640  1.000 39.59911 ? 7   ALA A N   1 
ATOM   51   C CA  . ALA A 1 7   ? -23.80825 -9.79243  14.25305  1.000 40.43676 ? 7   ALA A CA  1 
ATOM   52   C C   . ALA A 1 7   ? -23.69266 -9.71373  15.77584  1.000 43.87494 ? 7   ALA A C   1 
ATOM   53   O O   . ALA A 1 7   ? -24.63295 -10.03332 16.50976  1.000 40.04856 ? 7   ALA A O   1 
ATOM   54   C CB  . ALA A 1 7   ? -23.97215 -8.39228  13.65974  1.000 43.13140 ? 7   ALA A CB  1 
ATOM   55   N N   . PHE A 1 8   ? -22.50943 -9.30777  16.25032  1.000 39.73495 ? 8   PHE A N   1 
ATOM   56   C CA  . PHE A 1 8   ? -22.34785 -9.04191  17.67393  1.000 43.48639 ? 8   PHE A CA  1 
ATOM   57   C C   . PHE A 1 8   ? -23.12161 -7.78399  18.07115  1.000 44.71223 ? 8   PHE A C   1 
ATOM   58   O O   . PHE A 1 8   ? -23.30031 -6.87773  17.26137  1.000 38.52340 ? 8   PHE A O   1 
ATOM   59   C CB  . PHE A 1 8   ? -20.88085 -8.86398  18.04228  1.000 47.74129 ? 8   PHE A CB  1 
ATOM   60   C CG  . PHE A 1 8   ? -20.09659 -10.14053 18.05777  1.000 47.47688 ? 8   PHE A CG  1 
ATOM   61   C CD1 . PHE A 1 8   ? -20.18340 -11.00318 19.12920  1.000 49.63175 ? 8   PHE A CD1 1 
ATOM   62   C CD2 . PHE A 1 8   ? -19.25026 -10.46313 17.01043  1.000 48.02138 ? 8   PHE A CD2 1 
ATOM   63   C CE1 . PHE A 1 8   ? -19.46134 -12.17859 19.14684  1.000 51.25421 ? 8   PHE A CE1 1 
ATOM   64   C CE2 . PHE A 1 8   ? -18.52937 -11.64156 17.02271  1.000 47.93837 ? 8   PHE A CE2 1 
ATOM   65   C CZ  . PHE A 1 8   ? -18.63305 -12.49463 18.09817  1.000 48.06836 ? 8   PHE A CZ  1 
ATOM   66   N N   . PRO A 1 9   ? -23.63143 -7.72417  19.29993  1.000 47.86578 ? 9   PRO A N   1 
ATOM   67   C CA  . PRO A 1 9   ? -24.22426 -6.46893  19.77455  1.000 44.35380 ? 9   PRO A CA  1 
ATOM   68   C C   . PRO A 1 9   ? -23.17264 -5.37206  19.69577  1.000 43.36158 ? 9   PRO A C   1 
ATOM   69   O O   . PRO A 1 9   ? -22.02964 -5.56157  20.11234  1.000 46.96669 ? 9   PRO A O   1 
ATOM   70   C CB  . PRO A 1 9   ? -24.62961 -6.77793  21.22253  1.000 42.40165 ? 9   PRO A CB  1 
ATOM   71   C CG  . PRO A 1 9   ? -24.60354 -8.27269  21.33916  1.000 48.58401 ? 9   PRO A CG  1 
ATOM   72   C CD  . PRO A 1 9   ? -23.61132 -8.77118  20.33456  1.000 39.13838 ? 9   PRO A CD  1 
ATOM   73   N N   . SER A 1 10  ? -23.55693 -4.23151  19.12786  1.000 42.44197 ? 10  SER A N   1 
ATOM   74   C CA  . SER A 1 10  ? -22.60320 -3.22980  18.65752  1.000 41.52210 ? 10  SER A CA  1 
ATOM   75   C C   . SER A 1 10  ? -22.46201 -2.02839  19.58762  1.000 47.12143 ? 10  SER A C   1 
ATOM   76   O O   . SER A 1 10  ? -21.73625 -1.07629  19.24697  1.000 46.83747 ? 10  SER A O   1 
ATOM   77   C CB  . SER A 1 10  ? -23.00834 -2.74609  17.26187  1.000 36.21834 ? 10  SER A CB  1 
ATOM   78   O OG  . SER A 1 10  ? -24.23061 -2.02333  17.32626  1.000 41.92014 ? 10  SER A OG  1 
ATOM   79   N N   . GLY A 1 11  ? -23.11672 -2.05218  20.75104  1.000 42.11572 ? 11  GLY A N   1 
ATOM   80   C CA  . GLY A 1 11  ? -23.12058 -0.88380  21.61902  1.000 45.53589 ? 11  GLY A CA  1 
ATOM   81   C C   . GLY A 1 11  ? -21.73153 -0.42655  22.02925  1.000 45.87777 ? 11  GLY A C   1 
ATOM   82   O O   . GLY A 1 11  ? -21.45292 0.77049   22.06320  1.000 46.43582 ? 11  GLY A O   1 
ATOM   83   N N   . LYS A 1 12  ? -20.85339 -1.36818  22.38224  1.000 42.97450 ? 12  LYS A N   1 
ATOM   84   C CA  . LYS A 1 12  ? -19.51683 -1.00803  22.83639  1.000 43.42542 ? 12  LYS A CA  1 
ATOM   85   C C   . LYS A 1 12  ? -18.68304 -0.35191  21.74074  1.000 50.14000 ? 12  LYS A C   1 
ATOM   86   O O   . LYS A 1 12  ? -17.74944 0.40469   22.04902  1.000 53.86117 ? 12  LYS A O   1 
ATOM   87   C CB  . LYS A 1 12  ? -18.80074 -2.25085  23.36599  1.000 47.65150 ? 12  LYS A CB  1 
ATOM   88   C CG  . LYS A 1 12  ? -19.39528 -2.78377  24.66017  1.000 53.28156 ? 12  LYS A CG  1 
ATOM   89   C CD  . LYS A 1 12  ? -18.65259 -4.00479  25.18747  1.000 55.22803 ? 12  LYS A CD  1 
ATOM   90   C CE  . LYS A 1 12  ? -19.26629 -4.43950  26.51369  1.000 61.25605 ? 12  LYS A CE  1 
ATOM   91   N NZ  . LYS A 1 12  ? -18.77151 -5.77164  26.97794  1.000 72.46058 ? 12  LYS A NZ  1 
ATOM   92   N N   . VAL A 1 13  ? -18.99249 -0.62224  20.47588  1.000 46.07305 ? 13  VAL A N   1 
ATOM   93   C CA  . VAL A 1 13  ? -18.27975 0.01814   19.37555  1.000 46.25160 ? 13  VAL A CA  1 
ATOM   94   C C   . VAL A 1 13  ? -18.93284 1.33350   18.95309  1.000 48.21981 ? 13  VAL A C   1 
ATOM   95   O O   . VAL A 1 13  ? -18.22954 2.25259   18.51699  1.000 42.47384 ? 13  VAL A O   1 
ATOM   96   C CB  . VAL A 1 13  ? -18.16803 -0.95211  18.19105  1.000 41.16000 ? 13  VAL A CB  1 
ATOM   97   C CG1 . VAL A 1 13  ? -17.52973 -0.26069  16.99701  1.000 41.60347 ? 13  VAL A CG1 1 
ATOM   98   C CG2 . VAL A 1 13  ? -17.36922 -2.17128  18.60138  1.000 36.97895 ? 13  VAL A CG2 1 
ATOM   99   N N   . GLU A 1 14  ? -20.26318 1.45559   19.08432  1.000 44.76429 ? 14  GLU A N   1 
ATOM   100  C CA  . GLU A 1 14  ? -20.91085 2.73820   18.81255  1.000 43.64128 ? 14  GLU A CA  1 
ATOM   101  C C   . GLU A 1 14  ? -20.30716 3.84084   19.67430  1.000 44.05040 ? 14  GLU A C   1 
ATOM   102  O O   . GLU A 1 14  ? -20.08312 4.96079   19.20236  1.000 45.77095 ? 14  GLU A O   1 
ATOM   103  C CB  . GLU A 1 14  ? -22.42086 2.65693   19.06155  1.000 43.82897 ? 14  GLU A CB  1 
ATOM   104  C CG  . GLU A 1 14  ? -23.18779 1.61466   18.22091  1.000 40.13218 ? 14  GLU A CG  1 
ATOM   105  C CD  . GLU A 1 14  ? -24.57845 1.31906   18.78271  1.000 47.42387 ? 14  GLU A CD  1 
ATOM   106  O OE1 . GLU A 1 14  ? -25.27733 2.27307   19.17563  1.000 47.52006 ? 14  GLU A OE1 1 
ATOM   107  O OE2 . GLU A 1 14  ? -24.96981 0.13259   18.83825  1.000 43.44618 ? 14  GLU A OE2 1 
ATOM   108  N N   . GLY A 1 15  ? -20.02279 3.53667   20.94074  1.000 44.41481 ? 15  GLY A N   1 
ATOM   109  C CA  . GLY A 1 15  ? -19.44397 4.52865   21.82324  1.000 48.55981 ? 15  GLY A CA  1 
ATOM   110  C C   . GLY A 1 15  ? -18.05957 5.00190   21.41685  1.000 48.20163 ? 15  GLY A C   1 
ATOM   111  O O   . GLY A 1 15  ? -17.54301 5.93202   22.04277  1.000 47.89439 ? 15  GLY A O   1 
ATOM   112  N N   . CYS A 1 16  ? -17.44125 4.37688   20.41559  1.000 45.08417 ? 16  CYS A N   1 
ATOM   113  C CA  . CYS A 1 16  ? -16.09569 4.72711   19.98576  1.000 46.02894 ? 16  CYS A CA  1 
ATOM   114  C C   . CYS A 1 16  ? -16.05367 5.44913   18.65318  1.000 44.74289 ? 16  CYS A C   1 
ATOM   115  O O   . CYS A 1 16  ? -14.96512 5.75633   18.17322  1.000 48.97299 ? 16  CYS A O   1 
ATOM   116  C CB  . CYS A 1 16  ? -15.22004 3.48273   19.88260  1.000 48.05962 ? 16  CYS A CB  1 
ATOM   117  S SG  . CYS A 1 16  ? -15.14560 2.54376   21.37101  1.000 51.72034 ? 16  CYS A SG  1 
ATOM   118  N N   . MET A 1 17  ? -17.18783 5.71637   18.03076  1.000 46.14963 ? 17  MET A N   1 
ATOM   119  C CA  . MET A 1 17  ? -17.17122 6.27977   16.69371  1.000 45.47680 ? 17  MET A CA  1 
ATOM   120  C C   . MET A 1 17  ? -17.17084 7.80230   16.75581  1.000 49.17718 ? 17  MET A C   1 
ATOM   121  O O   . MET A 1 17  ? -17.85195 8.40806   17.59261  1.000 46.70388 ? 17  MET A O   1 
ATOM   122  C CB  . MET A 1 17  ? -18.36098 5.77274   15.88150  1.000 44.08198 ? 17  MET A CB  1 
ATOM   123  C CG  . MET A 1 17  ? -18.36749 4.24339   15.71746  1.000 44.05536 ? 17  MET A CG  1 
ATOM   124  S SD  . MET A 1 17  ? -16.79045 3.48831   15.21578  1.000 41.99349 ? 17  MET A SD  1 
ATOM   125  C CE  . MET A 1 17  ? -16.49424 4.28299   13.63137  1.000 44.16659 ? 17  MET A CE  1 
ATOM   126  N N   . VAL A 1 18  ? -16.38878 8.41521   15.86644  1.000 42.89529 ? 18  VAL A N   1 
ATOM   127  C CA  . VAL A 1 18  ? -16.29366 9.86331   15.77740  1.000 46.01037 ? 18  VAL A CA  1 
ATOM   128  C C   . VAL A 1 18  ? -16.10526 10.25602  14.31704  1.000 49.39735 ? 18  VAL A C   1 
ATOM   129  O O   . VAL A 1 18  ? -15.83797 9.42480   13.44079  1.000 47.98689 ? 18  VAL A O   1 
ATOM   130  C CB  . VAL A 1 18  ? -15.15490 10.43789  16.65151  1.000 47.27351 ? 18  VAL A CB  1 
ATOM   131  C CG1 . VAL A 1 18  ? -15.37140 10.09728  18.13748  1.000 39.16748 ? 18  VAL A CG1 1 
ATOM   132  C CG2 . VAL A 1 18  ? -13.77334 9.95940   16.14924  1.000 39.11013 ? 18  VAL A CG2 1 
ATOM   133  N N   . GLN A 1 19  ? -16.28006 11.54409  14.06717  1.000 46.18605 ? 19  GLN A N   1 
ATOM   134  C CA  . GLN A 1 19  ? -16.14877 12.12751  12.74636  1.000 45.87952 ? 19  GLN A CA  1 
ATOM   135  C C   . GLN A 1 19  ? -14.79181 12.80626  12.66556  1.000 45.41522 ? 19  GLN A C   1 
ATOM   136  O O   . GLN A 1 19  ? -14.35723 13.45258  13.62122  1.000 49.41569 ? 19  GLN A O   1 
ATOM   137  C CB  . GLN A 1 19  ? -17.27837 13.13320  12.50751  1.000 50.40375 ? 19  GLN A CB  1 
ATOM   138  C CG  . GLN A 1 19  ? -17.36013 13.71816  11.11853  1.000 51.25010 ? 19  GLN A CG  1 
ATOM   139  C CD  . GLN A 1 19  ? -18.66800 14.43573  10.90349  1.000 52.89704 ? 19  GLN A CD  1 
ATOM   140  O OE1 . GLN A 1 19  ? -19.11500 14.62164  9.77108   1.000 55.41978 ? 19  GLN A OE1 1 
ATOM   141  N NE2 . GLN A 1 19  ? -19.30199 14.83412  11.99640  1.000 57.30646 ? 19  GLN A NE2 1 
ATOM   142  N N   . VAL A 1 20  ? -14.10264 12.63095  11.54813  1.000 46.46787 ? 20  VAL A N   1 
ATOM   143  C CA  . VAL A 1 20  ? -12.80191 13.25479  11.35615  1.000 42.17263 ? 20  VAL A CA  1 
ATOM   144  C C   . VAL A 1 20  ? -12.82778 13.97474  10.02348  1.000 47.60663 ? 20  VAL A C   1 
ATOM   145  O O   . VAL A 1 20  ? -13.23056 13.39921  9.00652   1.000 46.40884 ? 20  VAL A O   1 
ATOM   146  C CB  . VAL A 1 20  ? -11.64082 12.24292  11.40233  1.000 40.71037 ? 20  VAL A CB  1 
ATOM   147  C CG1 . VAL A 1 20  ? -10.31570 12.96415  11.11673  1.000 46.34983 ? 20  VAL A CG1 1 
ATOM   148  C CG2 . VAL A 1 20  ? -11.58414 11.54512  12.73788  1.000 42.44661 ? 20  VAL A CG2 1 
ATOM   149  N N   . THR A 1 21  ? -12.39265 15.22951  10.03251  1.000 52.04764 ? 21  THR A N   1 
ATOM   150  C CA  . THR A 1 21  ? -12.46072 16.10383  8.87506   1.000 50.60125 ? 21  THR A CA  1 
ATOM   151  C C   . THR A 1 21  ? -11.10738 16.76143  8.67453   1.000 53.22946 ? 21  THR A C   1 
ATOM   152  O O   . THR A 1 21  ? -10.48880 17.23433  9.63485   1.000 53.28737 ? 21  THR A O   1 
ATOM   153  C CB  . THR A 1 21  ? -13.54759 17.16320  9.05932   1.000 54.63933 ? 21  THR A CB  1 
ATOM   154  O OG1 . THR A 1 21  ? -14.82709 16.51983  9.10076   1.000 51.80600 ? 21  THR A OG1 1 
ATOM   155  C CG2 . THR A 1 21  ? -13.51448 18.15800  7.92262   1.000 49.73588 ? 21  THR A CG2 1 
ATOM   156  N N   . CYS A 1 22  ? -10.63913 16.75037  7.43334   1.000 50.64589 ? 22  CYS A N   1 
ATOM   157  C CA  . CYS A 1 22  ? -9.41100  17.42123  7.05057   1.000 57.27947 ? 22  CYS A CA  1 
ATOM   158  C C   . CYS A 1 22  ? -9.65071  17.98759  5.66409   1.000 57.49311 ? 22  CYS A C   1 
ATOM   159  O O   . CYS A 1 22  ? -10.02416 17.25041  4.74621   1.000 58.34998 ? 22  CYS A O   1 
ATOM   160  C CB  . CYS A 1 22  ? -8.21904  16.46004  7.06838   1.000 55.00360 ? 22  CYS A CB  1 
ATOM   161  S SG  . CYS A 1 22  ? -6.64241  17.25200  6.74664   1.000 66.35903 ? 22  CYS A SG  1 
ATOM   162  N N   . GLY A 1 23  ? -9.47530  19.29183  5.52092   1.000 58.52235 ? 23  GLY A N   1 
ATOM   163  C CA  . GLY A 1 23  ? -9.88835  19.92293  4.28212   1.000 55.19396 ? 23  GLY A CA  1 
ATOM   164  C C   . GLY A 1 23  ? -11.37704 19.73742  4.10450   1.000 56.26087 ? 23  GLY A C   1 
ATOM   165  O O   . GLY A 1 23  ? -12.17622 20.03591  5.00095   1.000 60.19743 ? 23  GLY A O   1 
ATOM   166  N N   . THR A 1 24  ? -11.76411 19.20654  2.94538   1.000 59.68133 ? 24  THR A N   1 
ATOM   167  C CA  . THR A 1 24  ? -13.14728 18.83284  2.68743   1.000 62.88881 ? 24  THR A CA  1 
ATOM   168  C C   . THR A 1 24  ? -13.31870 17.32256  2.58057   1.000 61.51152 ? 24  THR A C   1 
ATOM   169  O O   . THR A 1 24  ? -14.23683 16.84368  1.91023   1.000 61.94411 ? 24  THR A O   1 
ATOM   170  C CB  . THR A 1 24  ? -13.66928 19.49606  1.41842   1.000 64.68141 ? 24  THR A CB  1 
ATOM   171  O OG1 . THR A 1 24  ? -12.76250 19.23534  0.33963   1.000 64.48092 ? 24  THR A OG1 1 
ATOM   172  C CG2 . THR A 1 24  ? -13.82880 20.99198  1.63082   1.000 65.09773 ? 24  THR A CG2 1 
ATOM   173  N N   . THR A 1 25  ? -12.43750 16.55705  3.21100   1.000 58.88587 ? 25  THR A N   1 
ATOM   174  C CA  . THR A 1 25  ? -12.62322 15.11731  3.30573   1.000 57.08169 ? 25  THR A CA  1 
ATOM   175  C C   . THR A 1 25  ? -13.09665 14.77013  4.70799   1.000 51.32753 ? 25  THR A C   1 
ATOM   176  O O   . THR A 1 25  ? -12.49509 15.19998  5.69885   1.000 53.52830 ? 25  THR A O   1 
ATOM   177  C CB  . THR A 1 25  ? -11.34536 14.35522  2.96798   1.000 55.28417 ? 25  THR A CB  1 
ATOM   178  O OG1 . THR A 1 25  ? -10.96586 14.66202  1.62435   1.000 61.41446 ? 25  THR A OG1 1 
ATOM   179  C CG2 . THR A 1 25  ? -11.61057 12.85962  3.06362   1.000 49.88913 ? 25  THR A CG2 1 
ATOM   180  N N   . THR A 1 26  ? -14.19266 14.02350  4.78805   1.000 53.74711 ? 26  THR A N   1 
ATOM   181  C CA  . THR A 1 26  ? -14.74331 13.60036  6.06545   1.000 50.31256 ? 26  THR A CA  1 
ATOM   182  C C   . THR A 1 26  ? -14.91249 12.09279  6.04261   1.000 43.89894 ? 26  THR A C   1 
ATOM   183  O O   . THR A 1 26  ? -15.40361 11.53239  5.05910   1.000 45.80475 ? 26  THR A O   1 
ATOM   184  C CB  . THR A 1 26  ? -16.08127 14.28356  6.36666   1.000 48.10675 ? 26  THR A CB  1 
ATOM   185  O OG1 . THR A 1 26  ? -15.87066 15.69351  6.50905   1.000 57.59735 ? 26  THR A OG1 1 
ATOM   186  C CG2 . THR A 1 26  ? -16.64538 13.76268  7.66374   1.000 51.97808 ? 26  THR A CG2 1 
ATOM   187  N N   . LEU A 1 27  ? -14.48890 11.44501  7.11832   1.000 43.39609 ? 27  LEU A N   1 
ATOM   188  C CA  . LEU A 1 27  ? -14.70779 10.02169  7.29261   1.000 44.12231 ? 27  LEU A CA  1 
ATOM   189  C C   . LEU A 1 27  ? -14.78566 9.74001   8.78644   1.000 43.74135 ? 27  LEU A C   1 
ATOM   190  O O   . LEU A 1 27  ? -14.74444 10.65851  9.61576   1.000 40.92129 ? 27  LEU A O   1 
ATOM   191  C CB  . LEU A 1 27  ? -13.60765 9.21697   6.58964   1.000 44.40346 ? 27  LEU A CB  1 
ATOM   192  C CG  . LEU A 1 27  ? -12.16041 9.70540   6.69946   1.000 38.11406 ? 27  LEU A CG  1 
ATOM   193  C CD1 . LEU A 1 27  ? -11.66366 9.73945   8.13065   1.000 36.84638 ? 27  LEU A CD1 1 
ATOM   194  C CD2 . LEU A 1 27  ? -11.29277 8.78299   5.89179   1.000 39.24652 ? 27  LEU A CD2 1 
ATOM   195  N N   . ASN A 1 28  ? -14.88894 8.45529   9.13356   1.000 38.61730 ? 28  ASN A N   1 
ATOM   196  C CA  . ASN A 1 28  ? -15.03856 8.06933   10.52558  1.000 32.80931 ? 28  ASN A CA  1 
ATOM   197  C C   . ASN A 1 28  ? -13.69758 7.73125   11.16053  1.000 33.13505 ? 28  ASN A C   1 
ATOM   198  O O   . ASN A 1 28  ? -12.76566 7.26735   10.49613  1.000 39.67236 ? 28  ASN A O   1 
ATOM   199  C CB  . ASN A 1 28  ? -15.98476 6.85890   10.66060  1.000 41.62579 ? 28  ASN A CB  1 
ATOM   200  C CG  . ASN A 1 28  ? -17.26420 7.03970   9.87326   1.000 37.01532 ? 28  ASN A CG  1 
ATOM   201  O OD1 . ASN A 1 28  ? -18.23145 7.60244   10.36793  1.000 39.99445 ? 28  ASN A OD1 1 
ATOM   202  N ND2 . ASN A 1 28  ? -17.25779 6.59731   8.62880   1.000 36.56516 ? 28  ASN A ND2 1 
ATOM   203  N N   . GLY A 1 29  ? -13.61013 7.95471   12.46993  1.000 36.96523 ? 29  GLY A N   1 
ATOM   204  C CA  . GLY A 1 29  ? -12.46475 7.51326   13.23370  1.000 38.10336 ? 29  GLY A CA  1 
ATOM   205  C C   . GLY A 1 29  ? -12.89584 6.73165   14.45199  1.000 39.00415 ? 29  GLY A C   1 
ATOM   206  O O   . GLY A 1 29  ? -14.03728 6.79394   14.89161  1.000 40.54204 ? 29  GLY A O   1 
ATOM   207  N N   . LEU A 1 30  ? -11.93861 6.00213   15.00937  1.000 41.83690 ? 30  LEU A N   1 
ATOM   208  C CA  . LEU A 1 30  ? -12.13314 5.13527   16.15708  1.000 42.95835 ? 30  LEU A CA  1 
ATOM   209  C C   . LEU A 1 30  ? -11.39666 5.72780   17.35123  1.000 45.29586 ? 30  LEU A C   1 
ATOM   210  O O   . LEU A 1 30  ? -10.16237 5.78266   17.35945  1.000 41.79066 ? 30  LEU A O   1 
ATOM   211  C CB  . LEU A 1 30  ? -11.62182 3.73064   15.85096  1.000 43.83378 ? 30  LEU A CB  1 
ATOM   212  C CG  . LEU A 1 30  ? -11.90760 2.62932   16.88198  1.000 46.73087 ? 30  LEU A CG  1 
ATOM   213  C CD1 . LEU A 1 30  ? -13.41112 2.31623   16.99208  1.000 43.32368 ? 30  LEU A CD1 1 
ATOM   214  C CD2 . LEU A 1 30  ? -11.11157 1.39538   16.53139  1.000 38.80275 ? 30  LEU A CD2 1 
ATOM   215  N N   . TRP A 1 31  ? -12.15128 6.14066   18.36178  1.000 43.68227 ? 31  TRP A N   1 
ATOM   216  C CA  . TRP A 1 31  ? -11.61384 6.84333   19.52150  1.000 48.97057 ? 31  TRP A CA  1 
ATOM   217  C C   . TRP A 1 31  ? -11.47183 5.85756   20.67851  1.000 49.50290 ? 31  TRP A C   1 
ATOM   218  O O   . TRP A 1 31  ? -12.47242 5.39619   21.23709  1.000 51.58866 ? 31  TRP A O   1 
ATOM   219  C CB  . TRP A 1 31  ? -12.52890 8.01310   19.88189  1.000 46.31672 ? 31  TRP A CB  1 
ATOM   220  C CG  . TRP A 1 31  ? -12.10932 8.84563   21.06738  1.000 55.81275 ? 31  TRP A CG  1 
ATOM   221  C CD1 . TRP A 1 31  ? -10.84076 9.02971   21.54844  1.000 53.82759 ? 31  TRP A CD1 1 
ATOM   222  C CD2 . TRP A 1 31  ? -12.97512 9.60529   21.92082  1.000 55.71870 ? 31  TRP A CD2 1 
ATOM   223  N NE1 . TRP A 1 31  ? -10.86940 9.85869   22.65072  1.000 53.12495 ? 31  TRP A NE1 1 
ATOM   224  C CE2 . TRP A 1 31  ? -12.16383 10.23361  22.89081  1.000 54.17003 ? 31  TRP A CE2 1 
ATOM   225  C CE3 . TRP A 1 31  ? -14.35795 9.82047   21.95303  1.000 54.08481 ? 31  TRP A CE3 1 
ATOM   226  C CZ2 . TRP A 1 31  ? -12.69042 11.05015  23.88524  1.000 59.22922 ? 31  TRP A CZ2 1 
ATOM   227  C CZ3 . TRP A 1 31  ? -14.87960 10.63453  22.93804  1.000 57.57845 ? 31  TRP A CZ3 1 
ATOM   228  C CH2 . TRP A 1 31  ? -14.04843 11.24076  23.89216  1.000 59.99576 ? 31  TRP A CH2 1 
ATOM   229  N N   . LEU A 1 32  ? -10.22742 5.53864   21.03368  1.000 52.49938 ? 32  LEU A N   1 
ATOM   230  C CA  . LEU A 1 32  ? -9.90899  4.65593   22.15212  1.000 49.89512 ? 32  LEU A CA  1 
ATOM   231  C C   . LEU A 1 32  ? -8.89423  5.35352   23.04827  1.000 53.42741 ? 32  LEU A C   1 
ATOM   232  O O   . LEU A 1 32  ? -7.79839  5.70252   22.59406  1.000 50.17659 ? 32  LEU A O   1 
ATOM   233  C CB  . LEU A 1 32  ? -9.35397  3.31962   21.65485  1.000 48.65295 ? 32  LEU A CB  1 
ATOM   234  C CG  . LEU A 1 32  ? -10.27809 2.55046   20.71292  1.000 51.79361 ? 32  LEU A CG  1 
ATOM   235  C CD1 . LEU A 1 32  ? -9.59884  1.30465   20.17422  1.000 50.33777 ? 32  LEU A CD1 1 
ATOM   236  C CD2 . LEU A 1 32  ? -11.58017 2.19362   21.42163  1.000 48.09258 ? 32  LEU A CD2 1 
ATOM   237  N N   . ASP A 1 33  ? -9.24633  5.54209   24.31674  1.000 56.53051 ? 33  ASP A N   1 
ATOM   238  C CA  . ASP A 1 33  ? -8.41146  6.31796   25.24548  1.000 56.67351 ? 33  ASP A CA  1 
ATOM   239  C C   . ASP A 1 33  ? -8.28267  7.71469   24.63833  1.000 57.44656 ? 33  ASP A C   1 
ATOM   240  O O   . ASP A 1 33  ? -9.30484  8.29556   24.23769  1.000 58.29934 ? 33  ASP A O   1 
ATOM   241  C CB  . ASP A 1 33  ? -7.10743  5.57248   25.50361  1.000 54.15786 ? 33  ASP A CB  1 
ATOM   242  C CG  . ASP A 1 33  ? -7.33443  4.20684   26.15388  1.000 60.44123 ? 33  ASP A CG  1 
ATOM   243  O OD1 . ASP A 1 33  ? -8.18517  4.12605   27.06530  1.000 56.63523 ? 33  ASP A OD1 1 
ATOM   244  O OD2 . ASP A 1 33  ? -6.66363  3.21933   25.75863  1.000 59.54082 ? 33  ASP A OD2 1 
ATOM   245  N N   . ASP A 1 34  ? -7.08129  8.28612   24.52660  1.000 58.19390 ? 34  ASP A N   1 
ATOM   246  C CA  . ASP A 1 34  ? -6.91812  9.62704   23.97355  1.000 54.52093 ? 34  ASP A CA  1 
ATOM   247  C C   . ASP A 1 34  ? -6.36930  9.60353   22.54970  1.000 58.75692 ? 34  ASP A C   1 
ATOM   248  O O   . ASP A 1 34  ? -5.63281  10.51445  22.14823  1.000 58.53113 ? 34  ASP A O   1 
ATOM   249  C CB  . ASP A 1 34  ? -6.03408  10.48914  24.88375  1.000 57.99613 ? 34  ASP A CB  1 
ATOM   250  C CG  . ASP A 1 34  ? -4.62879  9.91725   25.08891  1.000 59.88933 ? 34  ASP A CG  1 
ATOM   251  O OD1 . ASP A 1 34  ? -4.31830  8.83193   24.56103  1.000 54.98409 ? 34  ASP A OD1 1 
ATOM   252  O OD2 . ASP A 1 34  ? -3.82018  10.57638  25.78526  1.000 65.21006 ? 34  ASP A OD2 1 
ATOM   253  N N   . VAL A 1 35  ? -6.71575  8.57674   21.77345  1.000 52.82523 ? 35  VAL A N   1 
ATOM   254  C CA  . VAL A 1 35  ? -6.22489  8.42142   20.41054  1.000 48.78804 ? 35  VAL A CA  1 
ATOM   255  C C   . VAL A 1 35  ? -7.40328  8.18796   19.48336  1.000 50.77345 ? 35  VAL A C   1 
ATOM   256  O O   . VAL A 1 35  ? -8.32899  7.43842   19.81639  1.000 48.65401 ? 35  VAL A O   1 
ATOM   257  C CB  . VAL A 1 35  ? -5.22721  7.25998   20.29653  1.000 46.31382 ? 35  VAL A CB  1 
ATOM   258  C CG1 . VAL A 1 35  ? -4.76729  7.11456   18.85341  1.000 44.61259 ? 35  VAL A CG1 1 
ATOM   259  C CG2 . VAL A 1 35  ? -4.05959  7.48660   21.21554  1.000 45.96383 ? 35  VAL A CG2 1 
ATOM   260  N N   . VAL A 1 36  ? -7.36321  8.81247   18.31234  1.000 46.01418 ? 36  VAL A N   1 
ATOM   261  C CA  . VAL A 1 36  ? -8.37118  8.59010   17.28499  1.000 46.23418 ? 36  VAL A CA  1 
ATOM   262  C C   . VAL A 1 36  ? -7.68020  7.97847   16.07368  1.000 44.87089 ? 36  VAL A C   1 
ATOM   263  O O   . VAL A 1 36  ? -6.72326  8.55328   15.53878  1.000 47.56273 ? 36  VAL A O   1 
ATOM   264  C CB  . VAL A 1 36  ? -9.10975  9.88440   16.92190  1.000 39.44429 ? 36  VAL A CB  1 
ATOM   265  C CG1 . VAL A 1 36  ? -9.91781  9.69759   15.65683  1.000 37.64246 ? 36  VAL A CG1 1 
ATOM   266  C CG2 . VAL A 1 36  ? -9.99514  10.31413  18.07612  1.000 41.92684 ? 36  VAL A CG2 1 
ATOM   267  N N   . TYR A 1 37  ? -8.15398  6.80805   15.65375  1.000 41.44881 ? 37  TYR A N   1 
ATOM   268  C CA  . TYR A 1 37  ? -7.58939  6.06999   14.53052  1.000 41.18630 ? 37  TYR A CA  1 
ATOM   269  C C   . TYR A 1 37  ? -8.49513  6.26450   13.32650  1.000 42.88005 ? 37  TYR A C   1 
ATOM   270  O O   . TYR A 1 37  ? -9.72209  6.14117   13.45372  1.000 45.87977 ? 37  TYR A O   1 
ATOM   271  C CB  . TYR A 1 37  ? -7.49083  4.57458   14.85216  1.000 42.06698 ? 37  TYR A CB  1 
ATOM   272  C CG  . TYR A 1 37  ? -6.70816  4.23703   16.10001  1.000 40.28949 ? 37  TYR A CG  1 
ATOM   273  C CD1 . TYR A 1 37  ? -7.26471  4.39100   17.36285  1.000 40.79773 ? 37  TYR A CD1 1 
ATOM   274  C CD2 . TYR A 1 37  ? -5.40080  3.77631   16.01108  1.000 45.57835 ? 37  TYR A CD2 1 
ATOM   275  C CE1 . TYR A 1 37  ? -6.53570  4.08229   18.50610  1.000 41.28796 ? 37  TYR A CE1 1 
ATOM   276  C CE2 . TYR A 1 37  ? -4.67149  3.46457   17.14195  1.000 43.35203 ? 37  TYR A CE2 1 
ATOM   277  C CZ  . TYR A 1 37  ? -5.23839  3.62215   18.37792  1.000 40.99425 ? 37  TYR A CZ  1 
ATOM   278  O OH  . TYR A 1 37  ? -4.49211  3.31161   19.48243  1.000 48.79766 ? 37  TYR A OH  1 
ATOM   279  N N   . CYS A 1 38  ? -7.90549  6.53817   12.16525  1.000 36.92252 ? 38  CYS A N   1 
ATOM   280  C CA  . CYS A 1 38  ? -8.69342  6.72288   10.95596  1.000 36.95222 ? 38  CYS A CA  1 
ATOM   281  C C   . CYS A 1 38  ? -7.81139  6.44478   9.74996   1.000 35.20166 ? 38  CYS A C   1 
ATOM   282  O O   . CYS A 1 38  ? -6.58492  6.32436   9.87317   1.000 42.40725 ? 38  CYS A O   1 
ATOM   283  C CB  . CYS A 1 38  ? -9.30029  8.13409   10.89603  1.000 36.80955 ? 38  CYS A CB  1 
ATOM   284  S SG  . CYS A 1 38  ? -8.09716  9.46809   10.57634  1.000 40.71898 ? 38  CYS A SG  1 
ATOM   285  N N   . PRO A 1 39  ? -8.40086  6.29881   8.56830   1.000 36.68692 ? 39  PRO A N   1 
ATOM   286  C CA  . PRO A 1 39  ? -7.58023  6.08384   7.37391   1.000 34.48842 ? 39  PRO A CA  1 
ATOM   287  C C   . PRO A 1 39  ? -6.77381  7.33581   7.06538   1.000 39.12814 ? 39  PRO A C   1 
ATOM   288  O O   . PRO A 1 39  ? -7.26480  8.45432   7.21098   1.000 37.62934 ? 39  PRO A O   1 
ATOM   289  C CB  . PRO A 1 39  ? -8.60825  5.79541   6.27530   1.000 34.23635 ? 39  PRO A CB  1 
ATOM   290  C CG  . PRO A 1 39  ? -9.83262  5.25432   7.03900   1.000 36.26540 ? 39  PRO A CG  1 
ATOM   291  C CD  . PRO A 1 39  ? -9.83168  6.01057   8.34154   1.000 39.45563 ? 39  PRO A CD  1 
ATOM   292  N N   . ARG A 1 40  ? -5.52012  7.14219   6.65873   1.000 38.25265 ? 40  ARG A N   1 
ATOM   293  C CA  . ARG A 1 40  ? -4.68375  8.29504   6.35692   1.000 38.68539 ? 40  ARG A CA  1 
ATOM   294  C C   . ARG A 1 40  ? -5.17313  9.04869   5.13151   1.000 42.90766 ? 40  ARG A C   1 
ATOM   295  O O   . ARG A 1 40  ? -4.86745  10.24425  4.99817   1.000 44.13447 ? 40  ARG A O   1 
ATOM   296  C CB  . ARG A 1 40  ? -3.21604  7.87678   6.18918   1.000 40.20312 ? 40  ARG A CB  1 
ATOM   297  C CG  . ARG A 1 40  ? -2.89369  7.08382   4.93434   1.000 39.21422 ? 40  ARG A CG  1 
ATOM   298  C CD  . ARG A 1 40  ? -1.40058  6.73257   4.85765   1.000 34.71781 ? 40  ARG A CD  1 
ATOM   299  N NE  . ARG A 1 40  ? -1.13259  5.89306   3.70290   1.000 39.42403 ? 40  ARG A NE  1 
ATOM   300  C CZ  . ARG A 1 40  ? 0.05024   5.37729   3.41292   1.000 43.23904 ? 40  ARG A CZ  1 
ATOM   301  N NH1 . ARG A 1 40  ? 1.11148   5.62680   4.16294   1.000 46.01491 ? 40  ARG A NH1 1 
ATOM   302  N NH2 . ARG A 1 40  ? 0.16861   4.58571   2.34878   1.000 41.07649 ? 40  ARG A NH2 1 
ATOM   303  N N   . HIS A 1 41  ? -5.96289  8.41397   4.25425   1.000 37.83974 ? 41  HIS A N   1 
ATOM   304  C CA  . HIS A 1 41  ? -6.34989  9.18171   3.07187   1.000 43.75138 ? 41  HIS A CA  1 
ATOM   305  C C   . HIS A 1 41  ? -7.30983  10.31760  3.39857   1.000 42.67340 ? 41  HIS A C   1 
ATOM   306  O O   . HIS A 1 41  ? -7.73663  11.02669  2.48101   1.000 44.15349 ? 41  HIS A O   1 
ATOM   307  C CB  . HIS A 1 41  ? -6.94418  8.27524   1.98618   1.000 42.02294 ? 41  HIS A CB  1 
ATOM   308  C CG  . HIS A 1 41  ? -8.29020  7.70254   2.31497   1.000 43.68021 ? 41  HIS A CG  1 
ATOM   309  N ND1 . HIS A 1 41  ? -8.47755  6.36139   2.57316   1.000 41.65468 ? 41  HIS A ND1 1 
ATOM   310  C CD2 . HIS A 1 41  ? -9.51937  8.27136   2.37104   1.000 39.60359 ? 41  HIS A CD2 1 
ATOM   311  C CE1 . HIS A 1 41  ? -9.76185  6.13124   2.79459   1.000 42.02067 ? 41  HIS A CE1 1 
ATOM   312  N NE2 . HIS A 1 41  ? -10.41779 7.26967   2.67081   1.000 44.24885 ? 41  HIS A NE2 1 
ATOM   313  N N   . VAL A 1 42  ? -7.63764  10.52018  4.67633   1.000 34.64579 ? 42  VAL A N   1 
ATOM   314  C CA  . VAL A 1 42  ? -8.38996  11.70038  5.06947   1.000 42.14627 ? 42  VAL A CA  1 
ATOM   315  C C   . VAL A 1 42  ? -7.59359  12.98247  4.85247   1.000 46.00207 ? 42  VAL A C   1 
ATOM   316  O O   . VAL A 1 42  ? -8.19071  14.05976  4.75204   1.000 44.69444 ? 42  VAL A O   1 
ATOM   317  C CB  . VAL A 1 42  ? -8.81970  11.62062  6.53769   1.000 38.28349 ? 42  VAL A CB  1 
ATOM   318  C CG1 . VAL A 1 42  ? -7.61222  11.80023  7.46057   1.000 37.05929 ? 42  VAL A CG1 1 
ATOM   319  C CG2 . VAL A 1 42  ? -9.89655  12.63677  6.82079   1.000 43.24322 ? 42  VAL A CG2 1 
ATOM   320  N N   . ILE A 1 43  ? -6.25768  12.90402  4.80884   1.000 46.01789 ? 43  ILE A N   1 
ATOM   321  C CA  . ILE A 1 43  ? -5.45353  14.08921  4.51626   1.000 48.13888 ? 43  ILE A CA  1 
ATOM   322  C C   . ILE A 1 43  ? -5.33709  14.36067  3.02502   1.000 51.48039 ? 43  ILE A C   1 
ATOM   323  O O   . ILE A 1 43  ? -4.64785  15.31339  2.63343   1.000 50.73727 ? 43  ILE A O   1 
ATOM   324  C CB  . ILE A 1 43  ? -4.02808  14.01665  5.10971   1.000 40.93845 ? 43  ILE A CB  1 
ATOM   325  C CG1 . ILE A 1 43  ? -3.18791  12.93964  4.42771   1.000 42.45460 ? 43  ILE A CG1 1 
ATOM   326  C CG2 . ILE A 1 43  ? -4.05899  13.82493  6.62236   1.000 38.83742 ? 43  ILE A CG2 1 
ATOM   327  C CD1 . ILE A 1 43  ? -1.78909  12.79657  5.02816   1.000 42.53272 ? 43  ILE A CD1 1 
ATOM   328  N N   . CYS A 1 44  ? -5.98981  13.57050  2.17700   1.000 48.85520 ? 44  CYS A N   1 
ATOM   329  C CA  . CYS A 1 44  ? -5.94394  13.82576  0.74420   1.000 56.64989 ? 44  CYS A CA  1 
ATOM   330  C C   . CYS A 1 44  ? -7.11246  14.68369  0.27687   1.000 67.22383 ? 44  CYS A C   1 
ATOM   331  O O   . CYS A 1 44  ? -8.22337  14.61259  0.81430   1.000 65.75797 ? 44  CYS A O   1 
ATOM   332  C CB  . CYS A 1 44  ? -5.94993  12.53041  -0.04706  1.000 59.39276 ? 44  CYS A CB  1 
ATOM   333  S SG  . CYS A 1 44  ? -4.54064  11.53446  0.27163   1.000 60.11315 ? 44  CYS A SG  1 
ATOM   334  N N   . THR A 1 45  ? -6.83853  15.48868  -0.75266  1.000 72.14432 ? 45  THR A N   1 
ATOM   335  C CA  . THR A 1 45  ? -7.82220  16.26287  -1.49324  1.000 74.03664 ? 45  THR A CA  1 
ATOM   336  C C   . THR A 1 45  ? -8.18674  15.51878  -2.77743  1.000 76.47599 ? 45  THR A C   1 
ATOM   337  O O   . THR A 1 45  ? -7.66570  14.44121  -3.06760  1.000 75.56034 ? 45  THR A O   1 
ATOM   338  C CB  . THR A 1 45  ? -7.28624  17.66007  -1.83150  1.000 74.57206 ? 45  THR A CB  1 
ATOM   339  O OG1 . THR A 1 45  ? -6.30210  17.55643  -2.87097  1.000 75.07734 ? 45  THR A OG1 1 
ATOM   340  C CG2 . THR A 1 45  ? -6.65872  18.32348  -0.61122  1.000 70.00344 ? 45  THR A CG2 1 
ATOM   341  N N   . SER A 1 46  ? -9.07807  16.12079  -3.56981  1.000 79.03841 ? 46  SER A N   1 
ATOM   342  C CA  . SER A 1 46  ? -9.48159  15.53075  -4.84375  1.000 78.44610 ? 46  SER A CA  1 
ATOM   343  C C   . SER A 1 46  ? -8.27046  15.07142  -5.65281  1.000 82.44589 ? 46  SER A C   1 
ATOM   344  O O   . SER A 1 46  ? -8.13502  13.88596  -5.98296  1.000 83.80600 ? 46  SER A O   1 
ATOM   345  C CB  . SER A 1 46  ? -10.31282 16.53866  -5.64281  1.000 75.38863 ? 46  SER A CB  1 
ATOM   346  N N   . GLU A 1 47  ? -7.36890  16.00783  -5.97136  1.000 81.92509 ? 47  GLU A N   1 
ATOM   347  C CA  . GLU A 1 47  ? -6.20373  15.68463  -6.79312  1.000 79.57933 ? 47  GLU A CA  1 
ATOM   348  C C   . GLU A 1 47  ? -5.20362  14.79157  -6.05515  1.000 79.84277 ? 47  GLU A C   1 
ATOM   349  O O   . GLU A 1 47  ? -4.54111  13.95440  -6.68223  1.000 78.90640 ? 47  GLU A O   1 
ATOM   350  C CB  . GLU A 1 47  ? -5.52885  16.97583  -7.26029  1.000 75.94814 ? 47  GLU A CB  1 
ATOM   351  N N   . ASP A 1 48  ? -5.08574  14.94454  -4.73218  1.000 77.34136 ? 48  ASP A N   1 
ATOM   352  C CA  . ASP A 1 48  ? -4.09246  14.18297  -3.97666  1.000 73.79439 ? 48  ASP A CA  1 
ATOM   353  C C   . ASP A 1 48  ? -4.28334  12.67638  -4.14618  1.000 76.29705 ? 48  ASP A C   1 
ATOM   354  O O   . ASP A 1 48  ? -3.30282  11.92770  -4.24539  1.000 73.38422 ? 48  ASP A O   1 
ATOM   355  C CB  . ASP A 1 48  ? -4.15753  14.56204  -2.49055  1.000 72.73602 ? 48  ASP A CB  1 
ATOM   356  C CG  . ASP A 1 48  ? -3.64479  15.97588  -2.20846  1.000 75.32738 ? 48  ASP A CG  1 
ATOM   357  O OD1 . ASP A 1 48  ? -2.75287  16.45715  -2.94058  1.000 74.18160 ? 48  ASP A OD1 1 
ATOM   358  O OD2 . ASP A 1 48  ? -4.12367  16.60015  -1.23709  1.000 73.04751 ? 48  ASP A OD2 1 
ATOM   359  N N   . MET A 1 49  ? -5.53994  12.21453  -4.18325  1.000 76.93449 ? 49  MET A N   1 
ATOM   360  C CA  . MET A 1 49  ? -5.85047  10.78899  -4.06564  1.000 74.65291 ? 49  MET A CA  1 
ATOM   361  C C   . MET A 1 49  ? -5.35432  9.95911   -5.24701  1.000 72.14396 ? 49  MET A C   1 
ATOM   362  O O   . MET A 1 49  ? -5.23609  8.73552   -5.11622  1.000 70.66992 ? 49  MET A O   1 
ATOM   363  C CB  . MET A 1 49  ? -7.36525  10.59448  -3.90277  1.000 76.72692 ? 49  MET A CB  1 
ATOM   364  C CG  . MET A 1 49  ? -7.96003  11.20409  -2.62346  1.000 76.18988 ? 49  MET A CG  1 
ATOM   365  S SD  . MET A 1 49  ? -9.69571  10.75580  -2.34368  1.000 85.76793 ? 49  MET A SD  1 
ATOM   366  C CE  . MET A 1 49  ? -9.97104  11.36923  -0.67285  1.000 65.27349 ? 49  MET A CE  1 
ATOM   367  N N   . LEU A 1 50  ? -5.06120  10.58566  -6.39005  1.000 73.80517 ? 50  LEU A N   1 
ATOM   368  C CA  . LEU A 1 50  ? -4.62328  9.82681   -7.56073  1.000 74.31688 ? 50  LEU A CA  1 
ATOM   369  C C   . LEU A 1 50  ? -3.24069  9.21408   -7.35460  1.000 73.42316 ? 50  LEU A C   1 
ATOM   370  O O   . LEU A 1 50  ? -2.97593  8.09628   -7.81872  1.000 74.05808 ? 50  LEU A O   1 
ATOM   371  C CB  . LEU A 1 50  ? -4.62636  10.72483  -8.79916  1.000 73.77701 ? 50  LEU A CB  1 
ATOM   372  N N   . ASN A 1 51  ? -2.34608  9.92686   -6.66003  1.000 73.18840 ? 51  ASN A N   1 
ATOM   373  C CA  . ASN A 1 51  ? -0.94927  9.51681   -6.58686  1.000 69.27001 ? 51  ASN A CA  1 
ATOM   374  C C   . ASN A 1 51  ? -0.24597  10.16207  -5.39901  1.000 63.63140 ? 51  ASN A C   1 
ATOM   375  O O   . ASN A 1 51  ? 0.78039   10.83317  -5.56768  1.000 66.29399 ? 51  ASN A O   1 
ATOM   376  C CB  . ASN A 1 51  ? -0.24119  9.88608   -7.88670  1.000 73.47418 ? 51  ASN A CB  1 
ATOM   377  C CG  . ASN A 1 51  ? 1.00199   9.08412   -8.10830  1.000 74.63946 ? 51  ASN A CG  1 
ATOM   378  O OD1 . ASN A 1 51  ? 2.11494   9.56932   -7.90040  1.000 76.92701 ? 51  ASN A OD1 1 
ATOM   379  N ND2 . ASN A 1 51  ? 0.82659   7.83965   -8.54107  1.000 81.37752 ? 51  ASN A ND2 1 
ATOM   380  N N   . PRO A 1 52  ? -0.74410  9.96683   -4.18581  1.000 62.17985 ? 52  PRO A N   1 
ATOM   381  C CA  . PRO A 1 52  ? -0.26755  10.77236  -3.06177  1.000 57.98657 ? 52  PRO A CA  1 
ATOM   382  C C   . PRO A 1 52  ? 1.00409   10.21332  -2.44310  1.000 55.78246 ? 52  PRO A C   1 
ATOM   383  O O   . PRO A 1 52  ? 1.21517   9.00138   -2.37334  1.000 53.24098 ? 52  PRO A O   1 
ATOM   384  C CB  . PRO A 1 52  ? -1.43728  10.68863  -2.07363  1.000 53.87689 ? 52  PRO A CB  1 
ATOM   385  C CG  . PRO A 1 52  ? -1.94151  9.27853   -2.28684  1.000 55.30002 ? 52  PRO A CG  1 
ATOM   386  C CD  . PRO A 1 52  ? -1.74672  8.96919   -3.76016  1.000 57.65151 ? 52  PRO A CD  1 
ATOM   387  N N   . ASN A 1 53  ? 1.85420   11.11743  -1.96901  1.000 47.78177 ? 53  ASN A N   1 
ATOM   388  C CA  . ASN A 1 53  ? 2.91036   10.75584  -1.02752  1.000 48.22071 ? 53  ASN A CA  1 
ATOM   389  C C   . ASN A 1 53  ? 2.42291   11.19722  0.34487   1.000 49.25275 ? 53  ASN A C   1 
ATOM   390  O O   . ASN A 1 53  ? 2.32480   12.40032  0.61334   1.000 44.04117 ? 53  ASN A O   1 
ATOM   391  C CB  . ASN A 1 53  ? 4.25045   11.40566  -1.37617  1.000 49.24329 ? 53  ASN A CB  1 
ATOM   392  C CG  . ASN A 1 53  ? 5.38036   10.88008  -0.51407  1.000 43.61369 ? 53  ASN A CG  1 
ATOM   393  O OD1 . ASN A 1 53  ? 5.46183   11.18431  0.67864   1.000 42.12129 ? 53  ASN A OD1 1 
ATOM   394  N ND2 . ASN A 1 53  ? 6.23357   10.05278  -1.09970  1.000 49.49291 ? 53  ASN A ND2 1 
ATOM   395  N N   . TYR A 1 54  ? 2.07620   10.22480  1.20109   1.000 46.58176 ? 54  TYR A N   1 
ATOM   396  C CA  . TYR A 1 54  ? 1.40319   10.56301  2.45336   1.000 44.42486 ? 54  TYR A CA  1 
ATOM   397  C C   . TYR A 1 54  ? 2.36205   11.19952  3.44687   1.000 41.08660 ? 54  TYR A C   1 
ATOM   398  O O   . TYR A 1 54  ? 1.96257   12.06657  4.23357   1.000 39.74757 ? 54  TYR A O   1 
ATOM   399  C CB  . TYR A 1 54  ? 0.73732   9.31665   3.07082   1.000 42.66379 ? 54  TYR A CB  1 
ATOM   400  C CG  . TYR A 1 54  ? -0.50702  8.91157   2.33483   1.000 41.04886 ? 54  TYR A CG  1 
ATOM   401  C CD1 . TYR A 1 54  ? -1.66982  9.65198   2.46692   1.000 40.81873 ? 54  TYR A CD1 1 
ATOM   402  C CD2 . TYR A 1 54  ? -0.51380  7.82329   1.47081   1.000 44.77912 ? 54  TYR A CD2 1 
ATOM   403  C CE1 . TYR A 1 54  ? -2.80271  9.31615   1.78606   1.000 46.13601 ? 54  TYR A CE1 1 
ATOM   404  C CE2 . TYR A 1 54  ? -1.66158  7.46391   0.78345   1.000 46.02653 ? 54  TYR A CE2 1 
ATOM   405  C CZ  . TYR A 1 54  ? -2.80675  8.22065   0.94844   1.000 48.46571 ? 54  TYR A CZ  1 
ATOM   406  O OH  . TYR A 1 54  ? -3.96935  7.91103   0.27490   1.000 46.00367 ? 54  TYR A OH  1 
ATOM   407  N N   . GLU A 1 55  ? 3.60451   10.72589  3.48027   1.000 42.19468 ? 55  GLU A N   1 
ATOM   408  C CA  . GLU A 1 55  ? 4.61850   11.36126  4.30663   1.000 46.13771 ? 55  GLU A CA  1 
ATOM   409  C C   . GLU A 1 55  ? 4.76057   12.83300  3.92464   1.000 45.89227 ? 55  GLU A C   1 
ATOM   410  O O   . GLU A 1 55  ? 4.75868   13.72267  4.78396   1.000 41.77495 ? 55  GLU A O   1 
ATOM   411  C CB  . GLU A 1 55  ? 5.94354   10.61259  4.14537   1.000 48.02788 ? 55  GLU A CB  1 
ATOM   412  C CG  . GLU A 1 55  ? 7.06646   11.09759  5.05273   1.000 54.86644 ? 55  GLU A CG  1 
ATOM   413  C CD  . GLU A 1 55  ? 8.39157   10.39745  4.75551   1.000 63.81742 ? 55  GLU A CD  1 
ATOM   414  O OE1 . GLU A 1 55  ? 8.41735   9.51927   3.85683   1.000 64.25920 ? 55  GLU A OE1 1 
ATOM   415  O OE2 . GLU A 1 55  ? 9.40306   10.72290  5.42092   1.000 63.73325 ? 55  GLU A OE2 1 
ATOM   416  N N   . ASP A 1 56  ? 4.81621   13.10428  2.62772   1.000 43.51446 ? 56  ASP A N   1 
ATOM   417  C CA  . ASP A 1 56  ? 4.97270   14.47504  2.16680   1.000 48.75352 ? 56  ASP A CA  1 
ATOM   418  C C   . ASP A 1 56  ? 3.70577   15.28085  2.40310   1.000 50.39509 ? 56  ASP A C   1 
ATOM   419  O O   . ASP A 1 56  ? 3.78097   16.47158  2.73988   1.000 46.29441 ? 56  ASP A O   1 
ATOM   420  C CB  . ASP A 1 56  ? 5.36993   14.48032  0.68734   1.000 47.87698 ? 56  ASP A CB  1 
ATOM   421  C CG  . ASP A 1 56  ? 6.07549   15.77109  0.27537   1.000 50.76891 ? 56  ASP A CG  1 
ATOM   422  O OD1 . ASP A 1 56  ? 7.26427   15.94067  0.62597   1.000 49.72670 ? 56  ASP A OD1 1 
ATOM   423  O OD2 . ASP A 1 56  ? 5.43270   16.61052  -0.39361  1.000 50.90434 ? 56  ASP A OD2 1 
ATOM   424  N N   . LEU A 1 57  ? 2.53338   14.64895  2.28042   1.000 44.95218 ? 57  LEU A N   1 
ATOM   425  C CA  . LEU A 1 57  ? 1.30413   15.38694  2.54782   1.000 42.75883 ? 57  LEU A CA  1 
ATOM   426  C C   . LEU A 1 57  ? 1.13708   15.66239  4.03026   1.000 44.18825 ? 57  LEU A C   1 
ATOM   427  O O   . LEU A 1 57  ? 0.58825   16.70318  4.40432   1.000 46.84255 ? 57  LEU A O   1 
ATOM   428  C CB  . LEU A 1 57  ? 0.09380   14.63537  1.99626   1.000 50.04046 ? 57  LEU A CB  1 
ATOM   429  C CG  . LEU A 1 57  ? 0.04911   14.63002  0.46273   1.000 54.87963 ? 57  LEU A CG  1 
ATOM   430  C CD1 . LEU A 1 57  ? -0.79177  13.46929  -0.06707  1.000 51.12211 ? 57  LEU A CD1 1 
ATOM   431  C CD2 . LEU A 1 57  ? -0.46579  15.96039  -0.06530  1.000 51.08101 ? 57  LEU A CD2 1 
ATOM   432  N N   . LEU A 1 58  ? 1.62242   14.76487  4.88742   1.000 45.08533 ? 58  LEU A N   1 
ATOM   433  C CA  . LEU A 1 58  ? 1.32355   14.85776  6.31486   1.000 42.66686 ? 58  LEU A CA  1 
ATOM   434  C C   . LEU A 1 58  ? 2.24360   15.84508  7.02458   1.000 42.85279 ? 58  LEU A C   1 
ATOM   435  O O   . LEU A 1 58  ? 1.84330   16.47676  8.01122   1.000 40.82010 ? 58  LEU A O   1 
ATOM   436  C CB  . LEU A 1 58  ? 1.44249   13.48106  6.97537   1.000 36.99644 ? 58  LEU A CB  1 
ATOM   437  C CG  . LEU A 1 58  ? 1.05680   13.49773  8.45785   1.000 40.88236 ? 58  LEU A CG  1 
ATOM   438  C CD1 . LEU A 1 58  ? -0.41311  13.81825  8.60265   1.000 46.07656 ? 58  LEU A CD1 1 
ATOM   439  C CD2 . LEU A 1 58  ? 1.35597   12.15880  9.12896   1.000 50.32492 ? 58  LEU A CD2 1 
ATOM   440  N N   . ILE A 1 59  ? 3.50275   15.92195  6.59020   1.000 44.43698 ? 59  ILE A N   1 
ATOM   441  C CA  . ILE A 1 59  ? 4.43859   16.89238  7.15706   1.000 49.73899 ? 59  ILE A CA  1 
ATOM   442  C C   . ILE A 1 59  ? 3.88713   18.30612  7.00947   1.000 48.25433 ? 59  ILE A C   1 
ATOM   443  O O   . ILE A 1 59  ? 4.13078   19.17799  7.85712   1.000 50.48787 ? 59  ILE A O   1 
ATOM   444  C CB  . ILE A 1 59  ? 5.82476   16.73858  6.48222   1.000 51.84970 ? 59  ILE A CB  1 
ATOM   445  C CG1 . ILE A 1 59  ? 6.90685   17.49376  7.25312   1.000 52.12592 ? 59  ILE A CG1 1 
ATOM   446  C CG2 . ILE A 1 59  ? 5.78859   17.23373  5.05419   1.000 50.00141 ? 59  ILE A CG2 1 
ATOM   447  C CD1 . ILE A 1 59  ? 7.39102   16.73659  8.46955   1.000 56.90179 ? 59  ILE A CD1 1 
ATOM   448  N N   . ARG A 1 60  ? 3.11800   18.54428  5.94593   1.000 45.82537 ? 60  ARG A N   1 
ATOM   449  C CA  . ARG A 1 60  ? 2.55348   19.84188  5.61791   1.000 44.44924 ? 60  ARG A CA  1 
ATOM   450  C C   . ARG A 1 60  ? 1.32489   20.17849  6.44640   1.000 47.28892 ? 60  ARG A C   1 
ATOM   451  O O   . ARG A 1 60  ? 0.78974   21.27951  6.30065   1.000 47.87707 ? 60  ARG A O   1 
ATOM   452  C CB  . ARG A 1 60  ? 2.22404   19.89387  4.11550   1.000 40.24989 ? 60  ARG A CB  1 
ATOM   453  C CG  . ARG A 1 60  ? 3.44837   19.70313  3.20045   1.000 41.99629 ? 60  ARG A CG  1 
ATOM   454  C CD  . ARG A 1 60  ? 3.07234   19.72774  1.71587   1.000 40.99345 ? 60  ARG A CD  1 
ATOM   455  N NE  . ARG A 1 60  ? 4.13011   19.22690  0.83783   1.000 43.83239 ? 60  ARG A NE  1 
ATOM   456  C CZ  . ARG A 1 60  ? 5.09111   19.96922  0.28725   1.000 53.80823 ? 60  ARG A CZ  1 
ATOM   457  N NH1 . ARG A 1 60  ? 5.20011   21.26913  0.53837   1.000 44.33332 ? 60  ARG A NH1 1 
ATOM   458  N NH2 . ARG A 1 60  ? 5.97368   19.39257  -0.53076  1.000 47.95781 ? 60  ARG A NH2 1 
ATOM   459  N N   . LYS A 1 61  ? 0.88311   19.28495  7.33070   1.000 43.15569 ? 61  LYS A N   1 
ATOM   460  C CA  . LYS A 1 61  ? -0.33728  19.48106  8.09460   1.000 47.18518 ? 61  LYS A CA  1 
ATOM   461  C C   . LYS A 1 61  ? -0.02435  19.99236  9.49651   1.000 47.07741 ? 61  LYS A C   1 
ATOM   462  O O   . LYS A 1 61  ? 0.99690   19.64738  10.09386  1.000 50.43887 ? 61  LYS A O   1 
ATOM   463  C CB  . LYS A 1 61  ? -1.14144  18.16370  8.19593   1.000 45.94735 ? 61  LYS A CB  1 
ATOM   464  C CG  . LYS A 1 61  ? -2.32710  18.07631  7.25079   1.000 46.09803 ? 61  LYS A CG  1 
ATOM   465  C CD  . LYS A 1 61  ? -1.89982  17.89464  5.80194   1.000 50.35899 ? 61  LYS A CD  1 
ATOM   466  C CE  . LYS A 1 61  ? -3.12116  17.94235  4.88454   1.000 51.63077 ? 61  LYS A CE  1 
ATOM   467  N NZ  . LYS A 1 61  ? -4.03208  19.06840  5.22693   1.000 57.50431 ? 61  LYS A NZ  1 
ATOM   468  N N   . SER A 1 62  ? -0.94430  20.77377  10.04374  1.000 48.12270 ? 62  SER A N   1 
ATOM   469  C CA  . SER A 1 62  ? -0.91026  21.09217  11.46084  1.000 55.00752 ? 62  SER A CA  1 
ATOM   470  C C   . SER A 1 62  ? -2.02066  20.35000  12.20082  1.000 56.27477 ? 62  SER A C   1 
ATOM   471  O O   . SER A 1 62  ? -3.01253  19.91165  11.60985  1.000 55.63259 ? 62  SER A O   1 
ATOM   472  C CB  . SER A 1 62  ? -1.05191  22.59689  11.70130  1.000 54.64093 ? 62  SER A CB  1 
ATOM   473  O OG  . SER A 1 62  ? -1.15683  22.85550  13.09469  1.000 61.83319 ? 62  SER A OG  1 
ATOM   474  N N   . ASN A 1 63  ? -1.84312  20.22980  13.51935  1.000 54.74658 ? 63  ASN A N   1 
ATOM   475  C CA  . ASN A 1 63  ? -2.88986  19.66245  14.36155  1.000 55.61356 ? 63  ASN A CA  1 
ATOM   476  C C   . ASN A 1 63  ? -4.24168  20.30229  14.07664  1.000 57.52765 ? 63  ASN A C   1 
ATOM   477  O O   . ASN A 1 63  ? -5.26327  19.60904  14.00764  1.000 58.50927 ? 63  ASN A O   1 
ATOM   478  C CB  . ASN A 1 63  ? -2.52758  19.82541  15.83751  1.000 57.92280 ? 63  ASN A CB  1 
ATOM   479  C CG  . ASN A 1 63  ? -1.40343  18.89951  16.27568  1.000 64.89775 ? 63  ASN A CG  1 
ATOM   480  O OD1 . ASN A 1 63  ? -1.24515  17.79248  15.75205  1.000 64.63503 ? 63  ASN A OD1 1 
ATOM   481  N ND2 . ASN A 1 63  ? -0.62356  19.34426  17.25575  1.000 61.63937 ? 63  ASN A ND2 1 
ATOM   482  N N   . HIS A 1 64  ? -4.27294  21.62254  13.89061  1.000 52.74996 ? 64  HIS A N   1 
ATOM   483  C CA  . HIS A 1 64  ? -5.55332  22.30201  13.71938  1.000 51.01773 ? 64  HIS A CA  1 
ATOM   484  C C   . HIS A 1 64  ? -6.16867  22.07703  12.34680  1.000 48.68852 ? 64  HIS A C   1 
ATOM   485  O O   . HIS A 1 64  ? -7.30987  22.48884  12.13268  1.000 52.99486 ? 64  HIS A O   1 
ATOM   486  C CB  . HIS A 1 64  ? -5.40710  23.81016  13.99092  1.000 55.04892 ? 64  HIS A CB  1 
ATOM   487  C CG  . HIS A 1 64  ? -4.44282  24.50769  13.08263  1.000 58.00207 ? 64  HIS A CG  1 
ATOM   488  N ND1 . HIS A 1 64  ? -3.13536  24.76340  13.44120  1.000 59.88325 ? 64  HIS A ND1 1 
ATOM   489  C CD2 . HIS A 1 64  ? -4.59552  25.00890  11.83266  1.000 55.57447 ? 64  HIS A CD2 1 
ATOM   490  C CE1 . HIS A 1 64  ? -2.52491  25.39247  12.45106  1.000 57.56902 ? 64  HIS A CE1 1 
ATOM   491  N NE2 . HIS A 1 64  ? -3.38643  25.54703  11.46073  1.000 61.15284 ? 64  HIS A NE2 1 
ATOM   492  N N   . ASN A 1 65  ? -5.45250  21.44692  11.41012  1.000 54.72922 ? 65  ASN A N   1 
ATOM   493  C CA  . ASN A 1 65  ? -6.09014  21.01151  10.17091  1.000 53.15061 ? 65  ASN A CA  1 
ATOM   494  C C   . ASN A 1 65  ? -7.04393  19.82451  10.38535  1.000 52.77573 ? 65  ASN A C   1 
ATOM   495  O O   . ASN A 1 65  ? -7.79795  19.47640  9.46950   1.000 50.69259 ? 65  ASN A O   1 
ATOM   496  C CB  . ASN A 1 65  ? -5.02433  20.64200  9.12574   1.000 52.43920 ? 65  ASN A CB  1 
ATOM   497  C CG  . ASN A 1 65  ? -4.19609  21.84058  8.65637   1.000 54.35534 ? 65  ASN A CG  1 
ATOM   498  O OD1 . ASN A 1 65  ? -2.96464  21.80696  8.68480   1.000 51.83321 ? 65  ASN A OD1 1 
ATOM   499  N ND2 . ASN A 1 65  ? -4.87087  22.88616  8.19621   1.000 51.74420 ? 65  ASN A ND2 1 
ATOM   500  N N   . PHE A 1 66  ? -7.05207  19.20857  11.56612  1.000 51.04130 ? 66  PHE A N   1 
ATOM   501  C CA  . PHE A 1 66  ? -7.86484  18.01537  11.82384  1.000 53.02053 ? 66  PHE A CA  1 
ATOM   502  C C   . PHE A 1 66  ? -9.04726  18.39095  12.70891  1.000 51.08774 ? 66  PHE A C   1 
ATOM   503  O O   . PHE A 1 66  ? -8.86165  18.74601  13.87682  1.000 54.70493 ? 66  PHE A O   1 
ATOM   504  C CB  . PHE A 1 66  ? -7.03711  16.91643  12.49207  1.000 52.70266 ? 66  PHE A CB  1 
ATOM   505  C CG  . PHE A 1 66  ? -5.92916  16.37026  11.63335  1.000 53.92957 ? 66  PHE A CG  1 
ATOM   506  C CD1 . PHE A 1 66  ? -6.19414  15.41499  10.66047  1.000 51.38523 ? 66  PHE A CD1 1 
ATOM   507  C CD2 . PHE A 1 66  ? -4.62401  16.79829  11.81040  1.000 52.22365 ? 66  PHE A CD2 1 
ATOM   508  C CE1 . PHE A 1 66  ? -5.18007  14.90838  9.87442   1.000 52.40025 ? 66  PHE A CE1 1 
ATOM   509  C CE2 . PHE A 1 66  ? -3.59759  16.29218  11.02602  1.000 52.62310 ? 66  PHE A CE2 1 
ATOM   510  C CZ  . PHE A 1 66  ? -3.87500  15.34606  10.05694  1.000 52.52387 ? 66  PHE A CZ  1 
ATOM   511  N N   . LEU A 1 67  ? -10.25827 18.30140  12.16391  1.000 50.39133 ? 67  LEU A N   1 
ATOM   512  C CA  . LEU A 1 67  ? -11.47787 18.54666  12.92583  1.000 50.65380 ? 67  LEU A CA  1 
ATOM   513  C C   . LEU A 1 67  ? -12.09537 17.20080  13.31081  1.000 52.70932 ? 67  LEU A C   1 
ATOM   514  O O   . LEU A 1 67  ? -12.45119 16.40380  12.43453  1.000 50.92907 ? 67  LEU A O   1 
ATOM   515  C CB  . LEU A 1 67  ? -12.45794 19.39450  12.11175  1.000 51.49032 ? 67  LEU A CB  1 
ATOM   516  N N   . VAL A 1 68  ? -12.20881 16.94813  14.61441  1.000 52.84740 ? 68  VAL A N   1 
ATOM   517  C CA  . VAL A 1 68  ? -12.72211 15.69452  15.15715  1.000 54.36876 ? 68  VAL A CA  1 
ATOM   518  C C   . VAL A 1 68  ? -13.94875 16.01387  16.00721  1.000 57.58306 ? 68  VAL A C   1 
ATOM   519  O O   . VAL A 1 68  ? -13.86062 16.80212  16.95910  1.000 59.87678 ? 68  VAL A O   1 
ATOM   520  C CB  . VAL A 1 68  ? -11.65091 14.96574  15.98914  1.000 58.30851 ? 68  VAL A CB  1 
ATOM   521  C CG1 . VAL A 1 68  ? -12.15065 13.58162  16.46068  1.000 51.35758 ? 68  VAL A CG1 1 
ATOM   522  C CG2 . VAL A 1 68  ? -10.36113 14.84377  15.19622  1.000 53.41490 ? 68  VAL A CG2 1 
ATOM   523  N N   . GLN A 1 69  ? -15.08560 15.40122  15.67732  1.000 53.20051 ? 69  GLN A N   1 
ATOM   524  C CA  . GLN A 1 69  ? -16.33226 15.61269  16.40885  1.000 52.75174 ? 69  GLN A CA  1 
ATOM   525  C C   . GLN A 1 69  ? -16.82277 14.29361  16.98843  1.000 57.51462 ? 69  GLN A C   1 
ATOM   526  O O   . GLN A 1 69  ? -16.94807 13.29779  16.26432  1.000 51.40061 ? 69  GLN A O   1 
ATOM   527  C CB  . GLN A 1 69  ? -17.41258 16.22832  15.50917  1.000 51.59756 ? 69  GLN A CB  1 
ATOM   528  N N   . ALA A 1 70  ? -17.08810 14.29060  18.29209  1.000 54.00765 ? 70  ALA A N   1 
ATOM   529  C CA  . ALA A 1 70  ? -17.69168 13.16482  19.00173  1.000 57.50107 ? 70  ALA A CA  1 
ATOM   530  C C   . ALA A 1 70  ? -19.08641 13.62571  19.41768  1.000 62.73306 ? 70  ALA A C   1 
ATOM   531  O O   . ALA A 1 70  ? -19.26497 14.24394  20.46847  1.000 63.14278 ? 70  ALA A O   1 
ATOM   532  C CB  . ALA A 1 70  ? -16.85591 12.73924  20.20546  1.000 54.79048 ? 70  ALA A CB  1 
ATOM   533  N N   . GLY A 1 71  ? -20.07143 13.33199  18.57602  1.000 64.67471 ? 71  GLY A N   1 
ATOM   534  C CA  . GLY A 1 71  ? -21.39005 13.91483  18.76948  1.000 64.70724 ? 71  GLY A CA  1 
ATOM   535  C C   . GLY A 1 71  ? -21.33014 15.39387  18.45822  1.000 66.59396 ? 71  GLY A C   1 
ATOM   536  O O   . GLY A 1 71  ? -20.86634 15.80852  17.38769  1.000 70.27508 ? 71  GLY A O   1 
ATOM   537  N N   . ASN A 1 72  ? -21.78833 16.21273  19.40416  1.000 69.20466 ? 72  ASN A N   1 
ATOM   538  C CA  . ASN A 1 72  ? -21.66677 17.65650  19.24109  1.000 74.51415 ? 72  ASN A CA  1 
ATOM   539  C C   . ASN A 1 72  ? -20.27458 18.15844  19.61538  1.000 73.84813 ? 72  ASN A C   1 
ATOM   540  O O   . ASN A 1 72  ? -19.79949 19.14260  19.03747  1.000 77.05037 ? 72  ASN A O   1 
ATOM   541  C CB  . ASN A 1 72  ? -22.73177 18.36933  20.07992  1.000 78.97884 ? 72  ASN A CB  1 
ATOM   542  N N   . VAL A 1 73  ? -19.59852 17.48113  20.54297  1.000 70.79663 ? 73  VAL A N   1 
ATOM   543  C CA  . VAL A 1 73  ? -18.37084 17.99895  21.14189  1.000 68.89805 ? 73  VAL A CA  1 
ATOM   544  C C   . VAL A 1 73  ? -17.21519 17.91746  20.14835  1.000 67.01576 ? 73  VAL A C   1 
ATOM   545  O O   . VAL A 1 73  ? -16.82137 16.83084  19.70669  1.000 63.41920 ? 73  VAL A O   1 
ATOM   546  C CB  . VAL A 1 73  ? -18.03417 17.23646  22.42956  1.000 67.65945 ? 73  VAL A CB  1 
ATOM   547  C CG1 . VAL A 1 73  ? -16.70917 17.72019  22.99523  1.000 73.48537 ? 73  VAL A CG1 1 
ATOM   548  C CG2 . VAL A 1 73  ? -19.14445 17.39519  23.44831  1.000 67.72065 ? 73  VAL A CG2 1 
ATOM   549  N N   . GLN A 1 74  ? -16.64041 19.06748  19.81230  1.000 70.41697 ? 74  GLN A N   1 
ATOM   550  C CA  . GLN A 1 74  ? -15.37042 19.05396  19.10645  1.000 62.19003 ? 74  GLN A CA  1 
ATOM   551  C C   . GLN A 1 74  ? -14.29437 18.51519  20.03879  1.000 66.05487 ? 74  GLN A C   1 
ATOM   552  O O   . GLN A 1 74  ? -14.30098 18.78956  21.24194  1.000 69.41157 ? 74  GLN A O   1 
ATOM   553  C CB  . GLN A 1 74  ? -15.00519 20.45353  18.61355  1.000 65.76408 ? 74  GLN A CB  1 
ATOM   554  N N   . LEU A 1 75  ? -13.39572 17.70534  19.48873  1.000 62.31053 ? 75  LEU A N   1 
ATOM   555  C CA  . LEU A 1 75  ? -12.22454 17.21511  20.20387  1.000 61.96159 ? 75  LEU A CA  1 
ATOM   556  C C   . LEU A 1 75  ? -10.98485 17.88444  19.63162  1.000 64.91127 ? 75  LEU A C   1 
ATOM   557  O O   . LEU A 1 75  ? -10.81881 17.94154  18.40751  1.000 64.55756 ? 75  LEU A O   1 
ATOM   558  C CB  . LEU A 1 75  ? -12.09924 15.69365  20.08849  1.000 63.13779 ? 75  LEU A CB  1 
ATOM   559  C CG  . LEU A 1 75  ? -12.88004 14.87258  21.10700  1.000 64.11119 ? 75  LEU A CG  1 
ATOM   560  C CD1 . LEU A 1 75  ? -12.36553 13.44061  21.13984  1.000 62.71735 ? 75  LEU A CD1 1 
ATOM   561  C CD2 . LEU A 1 75  ? -12.77835 15.52480  22.47785  1.000 69.86356 ? 75  LEU A CD2 1 
ATOM   562  N N   . ARG A 1 76  ? -10.11474 18.38122  20.50749  1.000 64.18410 ? 76  ARG A N   1 
ATOM   563  C CA  . ARG A 1 76  ? -8.91132  19.07611  20.06718  1.000 60.93685 ? 76  ARG A CA  1 
ATOM   564  C C   . ARG A 1 76  ? -7.79692  18.07308  19.79311  1.000 58.92027 ? 76  ARG A C   1 
ATOM   565  O O   . ARG A 1 76  ? -7.45986  17.25380  20.65536  1.000 62.73644 ? 76  ARG A O   1 
ATOM   566  C CB  . ARG A 1 76  ? -8.46030  20.10304  21.10975  1.000 60.84778 ? 76  ARG A CB  1 
ATOM   567  N N   . VAL A 1 77  ? -7.22685  18.14769  18.59378  1.000 59.79064 ? 77  VAL A N   1 
ATOM   568  C CA  . VAL A 1 77  ? -6.08605  17.31832  18.22210  1.000 60.72521 ? 77  VAL A CA  1 
ATOM   569  C C   . VAL A 1 77  ? -4.81145  17.95962  18.75880  1.000 64.30846 ? 77  VAL A C   1 
ATOM   570  O O   . VAL A 1 77  ? -4.49892  19.11199  18.43842  1.000 58.60515 ? 77  VAL A O   1 
ATOM   571  C CB  . VAL A 1 77  ? -6.01109  17.13185  16.70175  1.000 56.56622 ? 77  VAL A CB  1 
ATOM   572  C CG1 . VAL A 1 77  ? -4.80780  16.27438  16.33617  1.000 58.16779 ? 77  VAL A CG1 1 
ATOM   573  C CG2 . VAL A 1 77  ? -7.30699  16.51632  16.18175  1.000 61.54345 ? 77  VAL A CG2 1 
ATOM   574  N N   . ILE A 1 78  ? -4.07224  17.20492  19.57171  1.000 63.43036 ? 78  ILE A N   1 
ATOM   575  C CA  . ILE A 1 78  ? -2.84273  17.65645  20.21146  1.000 63.69360 ? 78  ILE A CA  1 
ATOM   576  C C   . ILE A 1 78  ? -1.62572  16.90799  19.70659  1.000 64.26792 ? 78  ILE A C   1 
ATOM   577  O O   . ILE A 1 78  ? -0.50323  17.19010  20.15144  1.000 66.31095 ? 78  ILE A O   1 
ATOM   578  C CB  . ILE A 1 78  ? -2.94208  17.52807  21.74189  1.000 63.63613 ? 78  ILE A CB  1 
ATOM   579  C CG1 . ILE A 1 78  ? -3.07656  16.04858  22.12234  1.000 62.00524 ? 78  ILE A CG1 1 
ATOM   580  C CG2 . ILE A 1 78  ? -4.11252  18.35365  22.25714  1.000 56.43385 ? 78  ILE A CG2 1 
ATOM   581  C CD1 . ILE A 1 78  ? -2.99942  15.76564  23.60725  1.000 61.98317 ? 78  ILE A CD1 1 
ATOM   582  N N   . GLY A 1 79  ? -1.81186  15.94804  18.81355  1.000 60.94581 ? 79  GLY A N   1 
ATOM   583  C CA  . GLY A 1 79  ? -0.70350  15.22496  18.23179  1.000 57.19705 ? 79  GLY A CA  1 
ATOM   584  C C   . GLY A 1 79  ? -1.19370  14.41590  17.05665  1.000 56.71880 ? 79  GLY A C   1 
ATOM   585  O O   . GLY A 1 79  ? -2.39960  14.23145  16.86149  1.000 57.63385 ? 79  GLY A O   1 
ATOM   586  N N   . HIS A 1 80  ? -0.24515  13.96145  16.25341  1.000 53.63237 ? 80  HIS A N   1 
ATOM   587  C CA  . HIS A 1 80  ? -0.61968  13.06924  15.17576  1.000 52.19168 ? 80  HIS A CA  1 
ATOM   588  C C   . HIS A 1 80  ? 0.60743   12.31120  14.72624  1.000 56.89192 ? 80  HIS A C   1 
ATOM   589  O O   . HIS A 1 80  ? 1.73420   12.81688  14.77456  1.000 57.04044 ? 80  HIS A O   1 
ATOM   590  C CB  . HIS A 1 80  ? -1.26579  13.80416  13.99878  1.000 55.41084 ? 80  HIS A CB  1 
ATOM   591  C CG  . HIS A 1 80  ? -0.37610  14.81857  13.34807  1.000 53.95459 ? 80  HIS A CG  1 
ATOM   592  N ND1 . HIS A 1 80  ? -0.46680  16.16638  13.61726  1.000 57.18734 ? 80  HIS A ND1 1 
ATOM   593  C CD2 . HIS A 1 80  ? 0.60274   14.68413  12.41992  1.000 55.39427 ? 80  HIS A CD2 1 
ATOM   594  C CE1 . HIS A 1 80  ? 0.42996   16.81951  12.89404  1.000 59.43488 ? 80  HIS A CE1 1 
ATOM   595  N NE2 . HIS A 1 80  ? 1.09346   15.94265  12.15962  1.000 54.14084 ? 80  HIS A NE2 1 
ATOM   596  N N   . SER A 1 81  ? 0.36056   11.07895  14.31128  1.000 50.79080 ? 81  SER A N   1 
ATOM   597  C CA  . SER A 1 81  ? 1.37257   10.18710  13.78526  1.000 52.94857 ? 81  SER A CA  1 
ATOM   598  C C   . SER A 1 81  ? 0.71357   9.35758   12.69509  1.000 49.43466 ? 81  SER A C   1 
ATOM   599  O O   . SER A 1 81  ? -0.51119  9.19929   12.67576  1.000 54.96738 ? 81  SER A O   1 
ATOM   600  C CB  . SER A 1 81  ? 1.94459   9.30215   14.90116  1.000 52.32722 ? 81  SER A CB  1 
ATOM   601  O OG  . SER A 1 81  ? 2.41698   8.06505   14.40005  1.000 64.68430 ? 81  SER A OG  1 
ATOM   602  N N   . MET A 1 82  ? 1.52518   8.84433   11.78770  1.000 39.62482 ? 82  MET A N   1 
ATOM   603  C CA  . MET A 1 82  ? 1.07590   7.95373   10.73669  1.000 45.14623 ? 82  MET A CA  1 
ATOM   604  C C   . MET A 1 82  ? 1.69742   6.58824   11.00095  1.000 51.98426 ? 82  MET A C   1 
ATOM   605  O O   . MET A 1 82  ? 2.91842   6.48144   11.15403  1.000 54.37740 ? 82  MET A O   1 
ATOM   606  C CB  . MET A 1 82  ? 1.46699   8.48072   9.35968   1.000 43.44825 ? 82  MET A CB  1 
ATOM   607  C CG  . MET A 1 82  ? 1.16672   7.51841   8.24003   1.000 43.69662 ? 82  MET A CG  1 
ATOM   608  S SD  . MET A 1 82  ? 1.25467   8.22152   6.58017   1.000 51.98587 ? 82  MET A SD  1 
ATOM   609  C CE  . MET A 1 82  ? 2.99788   8.64655   6.46581   1.000 52.00657 ? 82  MET A CE  1 
ATOM   610  N N   . GLN A 1 83  ? 0.86081   5.55768   11.09529  1.000 44.13838 ? 83  GLN A N   1 
ATOM   611  C CA  . GLN A 1 83  ? 1.31638   4.16805   11.16422  1.000 44.84513 ? 83  GLN A CA  1 
ATOM   612  C C   . GLN A 1 83  ? 0.75486   3.42379   9.95669   1.000 43.54710 ? 83  GLN A C   1 
ATOM   613  O O   . GLN A 1 83  ? -0.44884  3.15066   9.89500   1.000 45.80727 ? 83  GLN A O   1 
ATOM   614  C CB  . GLN A 1 83  ? 0.88603   3.49861   12.47395  1.000 47.31688 ? 83  GLN A CB  1 
ATOM   615  C CG  . GLN A 1 83  ? 1.63302   2.18372   12.74520  1.000 47.63221 ? 83  GLN A CG  1 
ATOM   616  C CD  . GLN A 1 83  ? 1.03603   1.34545   13.85908  1.000 51.81625 ? 83  GLN A CD  1 
ATOM   617  O OE1 . GLN A 1 83  ? 0.10060   1.76760   14.54827  1.000 50.87831 ? 83  GLN A OE1 1 
ATOM   618  N NE2 . GLN A 1 83  ? 1.57929   0.13363   14.04053  1.000 50.49318 ? 83  GLN A NE2 1 
ATOM   619  N N   . ASN A 1 84  ? 1.62134   3.10736   8.99652   1.000 38.43633 ? 84  ASN A N   1 
ATOM   620  C CA  . ASN A 1 84  ? 1.23117   2.43825   7.75068   1.000 44.46043 ? 84  ASN A CA  1 
ATOM   621  C C   . ASN A 1 84  ? 0.05800   3.21863   7.15773   1.000 48.75860 ? 84  ASN A C   1 
ATOM   622  O O   . ASN A 1 84  ? 0.17518   4.44170   6.98954   1.000 46.00823 ? 84  ASN A O   1 
ATOM   623  C CB  . ASN A 1 84  ? 0.97630   0.97081   8.04699   1.000 45.32864 ? 84  ASN A CB  1 
ATOM   624  C CG  . ASN A 1 84  ? 2.15281   0.32295   8.73438   1.000 45.84428 ? 84  ASN A CG  1 
ATOM   625  O OD1 . ASN A 1 84  ? 3.20843   0.13638   8.12719   1.000 50.36391 ? 84  ASN A OD1 1 
ATOM   626  N ND2 . ASN A 1 84  ? 1.99701   0.01063   10.01368  1.000 46.96711 ? 84  ASN A ND2 1 
ATOM   627  N N   . CYS A 1 85  ? -1.07428  2.58789   6.82983   1.000 42.01188 ? 85  CYS A N   1 
ATOM   628  C CA  . CYS A 1 85  ? -2.13030  3.37017   6.19679   1.000 42.69370 ? 85  CYS A CA  1 
ATOM   629  C C   . CYS A 1 85  ? -3.09853  3.98638   7.19645   1.000 38.96399 ? 85  CYS A C   1 
ATOM   630  O O   . CYS A 1 85  ? -4.15236  4.48879   6.79377   1.000 34.16903 ? 85  CYS A O   1 
ATOM   631  C CB  . CYS A 1 85  ? -2.88894  2.53216   5.18264   1.000 40.35638 ? 85  CYS A CB  1 
ATOM   632  S SG  . CYS A 1 85  ? -1.82581  1.73085   4.01069   1.000 37.69923 ? 85  CYS A SG  1 
ATOM   633  N N   . VAL A 1 86  ? -2.76029  3.99603   8.47904   1.000 35.70652 ? 86  VAL A N   1 
ATOM   634  C CA  . VAL A 1 86  ? -3.65805  4.52397   9.49290   1.000 38.01799 ? 86  VAL A CA  1 
ATOM   635  C C   . VAL A 1 86  ? -3.06132  5.77788   10.11138  1.000 43.54977 ? 86  VAL A C   1 
ATOM   636  O O   . VAL A 1 86  ? -1.83883  5.90434   10.25932  1.000 41.80692 ? 86  VAL A O   1 
ATOM   637  C CB  . VAL A 1 86  ? -3.95588  3.45835   10.56458  1.000 42.23410 ? 86  VAL A CB  1 
ATOM   638  C CG1 . VAL A 1 86  ? -4.37239  4.10958   11.88067  1.000 43.55401 ? 86  VAL A CG1 1 
ATOM   639  C CG2 . VAL A 1 86  ? -5.05234  2.53044   10.04768  1.000 42.50752 ? 86  VAL A CG2 1 
ATOM   640  N N   . LEU A 1 87  ? -3.94181  6.71730   10.45637  1.000 43.28583 ? 87  LEU A N   1 
ATOM   641  C CA  . LEU A 1 87  ? -3.57195  7.94926   11.14438  1.000 45.33263 ? 87  LEU A CA  1 
ATOM   642  C C   . LEU A 1 87  ? -3.97107  7.83490   12.60487  1.000 46.32389 ? 87  LEU A C   1 
ATOM   643  O O   . LEU A 1 87  ? -5.12585  7.50943   12.91252  1.000 44.89083 ? 87  LEU A O   1 
ATOM   644  C CB  . LEU A 1 87  ? -4.25711  9.16947   10.52300  1.000 45.20312 ? 87  LEU A CB  1 
ATOM   645  C CG  . LEU A 1 87  ? -3.44044  10.27594  9.84739   1.000 52.06749 ? 87  LEU A CG  1 
ATOM   646  C CD1 . LEU A 1 87  ? -4.30548  11.50663  9.59832   1.000 46.01785 ? 87  LEU A CD1 1 
ATOM   647  C CD2 . LEU A 1 87  ? -2.21776  10.64910  10.67339  1.000 51.68647 ? 87  LEU A CD2 1 
ATOM   648  N N   . LYS A 1 88  ? -3.02121  8.10341   13.49939  1.000 46.99184 ? 88  LYS A N   1 
ATOM   649  C CA  . LYS A 1 88  ? -3.27376  8.14847   14.93446  1.000 45.42631 ? 88  LYS A CA  1 
ATOM   650  C C   . LYS A 1 88  ? -3.27564  9.60941   15.36764  1.000 49.87629 ? 88  LYS A C   1 
ATOM   651  O O   . LYS A 1 88  ? -2.22763  10.26451  15.34922  1.000 51.70910 ? 88  LYS A O   1 
ATOM   652  C CB  . LYS A 1 88  ? -2.22582  7.36192   15.71374  1.000 47.27365 ? 88  LYS A CB  1 
ATOM   653  C CG  . LYS A 1 88  ? -2.01623  5.91309   15.28462  1.000 49.75504 ? 88  LYS A CG  1 
ATOM   654  C CD  . LYS A 1 88  ? -1.42657  5.13380   16.46051  1.000 50.78309 ? 88  LYS A CD  1 
ATOM   655  C CE  . LYS A 1 88  ? -0.43671  4.08842   16.01318  1.000 59.10856 ? 88  LYS A CE  1 
ATOM   656  N NZ  . LYS A 1 88  ? 0.63047   4.69454   15.17854  1.000 55.29085 ? 88  LYS A NZ  1 
ATOM   657  N N   . LEU A 1 89  ? -4.44663  10.11402  15.77194  1.000 50.64401 ? 89  LEU A N   1 
ATOM   658  C CA  . LEU A 1 89  ? -4.61333  11.50403  16.19623  1.000 51.88976 ? 89  LEU A CA  1 
ATOM   659  C C   . LEU A 1 89  ? -4.74839  11.54749  17.71243  1.000 51.93435 ? 89  LEU A C   1 
ATOM   660  O O   . LEU A 1 89  ? -5.78344  11.14525  18.25429  1.000 50.30706 ? 89  LEU A O   1 
ATOM   661  C CB  . LEU A 1 89  ? -5.84512  12.13053  15.54860  1.000 47.21264 ? 89  LEU A CB  1 
ATOM   662  C CG  . LEU A 1 89  ? -5.96974  12.15213  14.03513  1.000 44.32112 ? 89  LEU A CG  1 
ATOM   663  C CD1 . LEU A 1 89  ? -7.29483  12.77465  13.66097  1.000 43.79470 ? 89  LEU A CD1 1 
ATOM   664  C CD2 . LEU A 1 89  ? -4.81603  12.94992  13.41820  1.000 46.47156 ? 89  LEU A CD2 1 
ATOM   665  N N   . LYS A 1 90  ? -3.71727  12.04127  18.39818  1.000 49.35930 ? 90  LYS A N   1 
ATOM   666  C CA  . LYS A 1 90  ? -3.82612  12.23797  19.83849  1.000 54.05561 ? 90  LYS A CA  1 
ATOM   667  C C   . LYS A 1 90  ? -4.78465  13.38912  20.12022  1.000 56.78795 ? 90  LYS A C   1 
ATOM   668  O O   . LYS A 1 90  ? -4.77569  14.40498  19.41779  1.000 57.85018 ? 90  LYS A O   1 
ATOM   669  C CB  . LYS A 1 90  ? -2.45286  12.51935  20.45518  1.000 60.01941 ? 90  LYS A CB  1 
ATOM   670  C CG  . LYS A 1 90  ? -2.42427  12.44612  21.98737  1.000 60.35474 ? 90  LYS A CG  1 
ATOM   671  C CD  . LYS A 1 90  ? -2.11812  11.03765  22.48155  1.000 63.68314 ? 90  LYS A CD  1 
ATOM   672  N N   . VAL A 1 91  ? -5.63171  13.21682  21.14026  1.000 55.46966 ? 91  VAL A N   1 
ATOM   673  C CA  . VAL A 1 91  ? -6.66853  14.18016  21.49041  1.000 56.58712 ? 91  VAL A CA  1 
ATOM   674  C C   . VAL A 1 91  ? -6.58490  14.49888  22.97966  1.000 60.54823 ? 91  VAL A C   1 
ATOM   675  O O   . VAL A 1 91  ? -5.94506  13.79010  23.75998  1.000 61.71463 ? 91  VAL A O   1 
ATOM   676  C CB  . VAL A 1 91  ? -8.09052  13.68886  21.12837  1.000 60.15188 ? 91  VAL A CB  1 
ATOM   677  C CG1 . VAL A 1 91  ? -8.32771  13.80464  19.63401  1.000 50.95501 ? 91  VAL A CG1 1 
ATOM   678  C CG2 . VAL A 1 91  ? -8.32109  12.25314  21.61908  1.000 57.87018 ? 91  VAL A CG2 1 
ATOM   679  N N   . ASP A 1 92  ? -7.24625  15.59100  23.36721  1.000 63.28992 ? 92  ASP A N   1 
ATOM   680  C CA  . ASP A 1 92  ? -7.16215  16.12504  24.72265  1.000 65.13916 ? 92  ASP A CA  1 
ATOM   681  C C   . ASP A 1 92  ? -8.17906  15.51119  25.67684  1.000 69.04444 ? 92  ASP A C   1 
ATOM   682  O O   . ASP A 1 92  ? -8.38546  16.04813  26.77081  1.000 68.85299 ? 92  ASP A O   1 
ATOM   683  C CB  . ASP A 1 92  ? -7.32908  17.65081  24.70179  1.000 69.01217 ? 92  ASP A CB  1 
ATOM   684  C CG  . ASP A 1 92  ? -8.67614  18.08943  24.15385  1.000 71.14449 ? 92  ASP A CG  1 
ATOM   685  O OD1 . ASP A 1 92  ? -9.55762  17.22436  23.94911  1.000 73.00898 ? 92  ASP A OD1 1 
ATOM   686  O OD2 . ASP A 1 92  ? -8.85025  19.30574  23.91946  1.000 71.38664 ? 92  ASP A OD2 1 
ATOM   687  N N   . THR A 1 93  ? -8.80955  14.40233  25.29540  1.000 64.66153 ? 93  THR A N   1 
ATOM   688  C CA  . THR A 1 93  ? -9.84747  13.78806  26.11379  1.000 62.95017 ? 93  THR A CA  1 
ATOM   689  C C   . THR A 1 93  ? -9.80695  12.28869  25.87530  1.000 62.44184 ? 93  THR A C   1 
ATOM   690  O O   . THR A 1 93  ? -9.94295  11.84758  24.73150  1.000 60.21000 ? 93  THR A O   1 
ATOM   691  C CB  . THR A 1 93  ? -11.22141 14.34852  25.75028  1.000 61.63235 ? 93  THR A CB  1 
ATOM   692  O OG1 . THR A 1 93  ? -11.09668 15.73938  25.43076  1.000 70.54118 ? 93  THR A OG1 1 
ATOM   693  C CG2 . THR A 1 93  ? -12.19533 14.18814  26.90255  1.000 66.28783 ? 93  THR A CG2 1 
ATOM   694  N N   . ALA A 1 94  ? -9.59470  11.51105  26.93152  1.000 58.46896 ? 94  ALA A N   1 
ATOM   695  C CA  . ALA A 1 94  ? -9.72856  10.06877  26.80307  1.000 58.57795 ? 94  ALA A CA  1 
ATOM   696  C C   . ALA A 1 94  ? -11.20506 9.71227   26.68338  1.000 58.29626 ? 94  ALA A C   1 
ATOM   697  O O   . ALA A 1 94  ? -12.04860 10.26435  27.39461  1.000 57.89711 ? 94  ALA A O   1 
ATOM   698  C CB  . ALA A 1 94  ? -9.09491  9.35570   27.99796  1.000 52.66626 ? 94  ALA A CB  1 
ATOM   699  N N   . ASN A 1 95  ? -11.52278 8.80793   25.75917  1.000 59.61311 ? 95  ASN A N   1 
ATOM   700  C CA  . ASN A 1 95  ? -12.90326 8.35132   25.60462  1.000 56.84760 ? 95  ASN A CA  1 
ATOM   701  C C   . ASN A 1 95  ? -13.39240 7.75064   26.91729  1.000 55.01544 ? 95  ASN A C   1 
ATOM   702  O O   . ASN A 1 95  ? -12.82185 6.75392   27.38299  1.000 56.40915 ? 95  ASN A O   1 
ATOM   703  C CB  . ASN A 1 95  ? -13.02323 7.32105   24.47843  1.000 58.03992 ? 95  ASN A CB  1 
ATOM   704  C CG  . ASN A 1 95  ? -14.47962 7.01291   24.10213  1.000 52.65672 ? 95  ASN A CG  1 
ATOM   705  O OD1 . ASN A 1 95  ? -15.41505 7.34821   24.82595  1.000 54.05149 ? 95  ASN A OD1 1 
ATOM   706  N ND2 . ASN A 1 95  ? -14.66288 6.36990   22.96204  1.000 53.31999 ? 95  ASN A ND2 1 
ATOM   707  N N   . PRO A 1 96  ? -14.42932 8.31258   27.54180  1.000 51.98626 ? 96  PRO A N   1 
ATOM   708  C CA  . PRO A 1 96  ? -14.96083 7.70224   28.76902  1.000 57.95189 ? 96  PRO A CA  1 
ATOM   709  C C   . PRO A 1 96  ? -15.66956 6.37951   28.51757  1.000 57.41797 ? 96  PRO A C   1 
ATOM   710  O O   . PRO A 1 96  ? -15.78209 5.56535   29.44413  1.000 56.10449 ? 96  PRO A O   1 
ATOM   711  C CB  . PRO A 1 96  ? -15.92654 8.76905   29.30094  1.000 53.56978 ? 96  PRO A CB  1 
ATOM   712  C CG  . PRO A 1 96  ? -16.36965 9.51994   28.07162  1.000 52.75939 ? 96  PRO A CG  1 
ATOM   713  C CD  . PRO A 1 96  ? -15.22208 9.47140   27.09269  1.000 55.04203 ? 96  PRO A CD  1 
ATOM   714  N N   . LYS A 1 97  ? -16.13446 6.14162   27.29089  1.000 58.15274 ? 97  LYS A N   1 
ATOM   715  C CA  . LYS A 1 97  ? -16.77750 4.89535   26.90266  1.000 58.87930 ? 97  LYS A CA  1 
ATOM   716  C C   . LYS A 1 97  ? -15.80195 3.90246   26.29626  1.000 56.05611 ? 97  LYS A C   1 
ATOM   717  O O   . LYS A 1 97  ? -16.22869 3.00895   25.56196  1.000 54.80250 ? 97  LYS A O   1 
ATOM   718  C CB  . LYS A 1 97  ? -17.90947 5.16876   25.90926  1.000 56.68430 ? 97  LYS A CB  1 
ATOM   719  C CG  . LYS A 1 97  ? -19.02827 6.01962   26.46761  1.000 59.36752 ? 97  LYS A CG  1 
ATOM   720  C CD  . LYS A 1 97  ? -19.95620 6.45567   25.35852  1.000 59.33281 ? 97  LYS A CD  1 
ATOM   721  C CE  . LYS A 1 97  ? -21.28300 6.94586   25.90966  1.000 62.18067 ? 97  LYS A CE  1 
ATOM   722  N NZ  . LYS A 1 97  ? -22.23880 7.25679   24.80640  1.000 65.45876 ? 97  LYS A NZ  1 
ATOM   723  N N   . THR A 1 98  ? -14.50937 4.05053   26.55421  1.000 55.31956 ? 98  THR A N   1 
ATOM   724  C CA  . THR A 1 98  ? -13.55187 3.10252   26.00637  1.000 56.00901 ? 98  THR A CA  1 
ATOM   725  C C   . THR A 1 98  ? -13.77479 1.73795   26.64909  1.000 52.48075 ? 98  THR A C   1 
ATOM   726  O O   . THR A 1 98  ? -13.74046 1.62738   27.87979  1.000 53.14410 ? 98  THR A O   1 
ATOM   727  C CB  . THR A 1 98  ? -12.10911 3.55887   26.23804  1.000 54.34575 ? 98  THR A CB  1 
ATOM   728  O OG1 . THR A 1 98  ? -11.89395 4.82940   25.61309  1.000 54.36085 ? 98  THR A OG1 1 
ATOM   729  C CG2 . THR A 1 98  ? -11.12888 2.54597   25.64197  1.000 52.65316 ? 98  THR A CG2 1 
ATOM   730  N N   . PRO A 1 99  ? -13.99800 0.68818   25.86849  1.000 53.22927 ? 99  PRO A N   1 
ATOM   731  C CA  . PRO A 1 99  ? -14.14350 -0.65353  26.43040  1.000 49.75644 ? 99  PRO A CA  1 
ATOM   732  C C   . PRO A 1 99  ? -12.81179 -1.39269  26.44979  1.000 55.58304 ? 99  PRO A C   1 
ATOM   733  O O   . PRO A 1 99  ? -11.84050 -1.00995  25.78574  1.000 54.67815 ? 99  PRO A O   1 
ATOM   734  C CB  . PRO A 1 99  ? -15.09736 -1.31468  25.43477  1.000 54.46374 ? 99  PRO A CB  1 
ATOM   735  C CG  . PRO A 1 99  ? -14.57649 -0.77419  24.12190  1.000 53.50680 ? 99  PRO A CG  1 
ATOM   736  C CD  . PRO A 1 99  ? -14.21056 0.67780   24.41170  1.000 50.82148 ? 99  PRO A CD  1 
ATOM   737  N N   . LYS A 1 100 ? -12.79307 -2.48808  27.20542  1.000 53.24615 ? 100 LYS A N   1 
ATOM   738  C CA  . LYS A 1 100 ? -11.70491 -3.44077  27.06622  1.000 56.28604 ? 100 LYS A CA  1 
ATOM   739  C C   . LYS A 1 100 ? -11.60128 -3.84193  25.60595  1.000 53.55608 ? 100 LYS A C   1 
ATOM   740  O O   . LYS A 1 100 ? -12.61334 -4.12032  24.95798  1.000 51.35743 ? 100 LYS A O   1 
ATOM   741  C CB  . LYS A 1 100 ? -11.94394 -4.67020  27.94303  1.000 53.08084 ? 100 LYS A CB  1 
ATOM   742  C CG  . LYS A 1 100 ? -10.73994 -5.59418  28.03070  1.000 53.66914 ? 100 LYS A CG  1 
ATOM   743  N N   . TYR A 1 101 ? -10.38139 -3.84208  25.08036  1.000 50.85078 ? 101 TYR A N   1 
ATOM   744  C CA  . TYR A 1 101 ? -10.21653 -3.99533  23.64381  1.000 51.71789 ? 101 TYR A CA  1 
ATOM   745  C C   . TYR A 1 101 ? -8.81337  -4.47425  23.32608  1.000 54.07455 ? 101 TYR A C   1 
ATOM   746  O O   . TYR A 1 101 ? -7.88022  -4.31328  24.11696  1.000 60.39142 ? 101 TYR A O   1 
ATOM   747  C CB  . TYR A 1 101 ? -10.48311 -2.68368  22.91074  1.000 54.13435 ? 101 TYR A CB  1 
ATOM   748  C CG  . TYR A 1 101 ? -9.33098  -1.69500  22.95463  1.000 53.06771 ? 101 TYR A CG  1 
ATOM   749  C CD1 . TYR A 1 101 ? -9.24442  -0.74515  23.96455  1.000 54.83837 ? 101 TYR A CD1 1 
ATOM   750  C CD2 . TYR A 1 101 ? -8.34885  -1.69526  21.97141  1.000 53.28413 ? 101 TYR A CD2 1 
ATOM   751  C CE1 . TYR A 1 101 ? -8.21068  0.17452   23.99627  1.000 55.11054 ? 101 TYR A CE1 1 
ATOM   752  C CE2 . TYR A 1 101 ? -7.30346  -0.77768  21.99872  1.000 53.82340 ? 101 TYR A CE2 1 
ATOM   753  C CZ  . TYR A 1 101 ? -7.24438  0.15222   23.01306  1.000 58.36409 ? 101 TYR A CZ  1 
ATOM   754  O OH  . TYR A 1 101 ? -6.21571  1.06011   23.05467  1.000 59.93277 ? 101 TYR A OH  1 
ATOM   755  N N   . LYS A 1 102 ? -8.67645  -5.04833  22.13757  1.000 48.65872 ? 102 LYS A N   1 
ATOM   756  C CA  . LYS A 1 102 ? -7.36746  -5.34743  21.60159  1.000 48.59439 ? 102 LYS A CA  1 
ATOM   757  C C   . LYS A 1 102 ? -7.43106  -5.15707  20.09566  1.000 48.42950 ? 102 LYS A C   1 
ATOM   758  O O   . LYS A 1 102 ? -8.51099  -5.04246  19.51150  1.000 47.46476 ? 102 LYS A O   1 
ATOM   759  C CB  . LYS A 1 102 ? -6.90089  -6.75748  21.98903  1.000 51.43616 ? 102 LYS A CB  1 
ATOM   760  C CG  . LYS A 1 102 ? -7.74695  -7.88086  21.44851  1.000 50.87288 ? 102 LYS A CG  1 
ATOM   761  N N   . PHE A 1 103 ? -6.25490  -5.05781  19.48587  1.000 44.37893 ? 103 PHE A N   1 
ATOM   762  C CA  . PHE A 1 103 ? -6.10632  -5.04038  18.04093  1.000 43.68425 ? 103 PHE A CA  1 
ATOM   763  C C   . PHE A 1 103 ? -5.57914  -6.39718  17.61598  1.000 46.20314 ? 103 PHE A C   1 
ATOM   764  O O   . PHE A 1 103 ? -4.58144  -6.86900  18.16596  1.000 48.52821 ? 103 PHE A O   1 
ATOM   765  C CB  . PHE A 1 103 ? -5.13993  -3.93664  17.58561  1.000 44.53518 ? 103 PHE A CB  1 
ATOM   766  C CG  . PHE A 1 103 ? -5.65153  -2.53483  17.81206  1.000 44.16504 ? 103 PHE A CG  1 
ATOM   767  C CD1 . PHE A 1 103 ? -6.99492  -2.31228  18.09352  1.000 42.96597 ? 103 PHE A CD1 1 
ATOM   768  C CD2 . PHE A 1 103 ? -4.78962  -1.43826  17.72468  1.000 45.45828 ? 103 PHE A CD2 1 
ATOM   769  C CE1 . PHE A 1 103 ? -7.47665  -1.04175  18.29801  1.000 39.76511 ? 103 PHE A CE1 1 
ATOM   770  C CE2 . PHE A 1 103 ? -5.25898  -0.14768  17.92025  1.000 40.21677 ? 103 PHE A CE2 1 
ATOM   771  C CZ  . PHE A 1 103 ? -6.59942  0.05769   18.19880  1.000 49.50924 ? 103 PHE A CZ  1 
ATOM   772  N N   . VAL A 1 104 ? -6.25623  -7.03782  16.66509  1.000 44.30463 ? 104 VAL A N   1 
ATOM   773  C CA  . VAL A 1 104 ? -5.81708  -8.33241  16.16505  1.000 43.19814 ? 104 VAL A CA  1 
ATOM   774  C C   . VAL A 1 104 ? -5.96601  -8.32880  14.65940  1.000 42.63847 ? 104 VAL A C   1 
ATOM   775  O O   . VAL A 1 104 ? -6.79805  -7.61136  14.09717  1.000 45.40044 ? 104 VAL A O   1 
ATOM   776  C CB  . VAL A 1 104 ? -6.59662  -9.52958  16.76159  1.000 48.63012 ? 104 VAL A CB  1 
ATOM   777  C CG1 . VAL A 1 104 ? -6.90010  -9.32447  18.24143  1.000 45.63924 ? 104 VAL A CG1 1 
ATOM   778  C CG2 . VAL A 1 104 ? -7.86026  -9.77799  15.96446  1.000 46.64910 ? 104 VAL A CG2 1 
ATOM   779  N N   . ARG A 1 105 ? -5.14290  -9.13355  14.00702  1.000 40.95460 ? 105 ARG A N   1 
ATOM   780  C CA  . ARG A 1 105 ? -5.25535  -9.36964  12.57793  1.000 39.62056 ? 105 ARG A CA  1 
ATOM   781  C C   . ARG A 1 105 ? -5.91051  -10.72797 12.36923  1.000 46.71759 ? 105 ARG A C   1 
ATOM   782  O O   . ARG A 1 105 ? -5.44306  -11.73397 12.91246  1.000 45.16867 ? 105 ARG A O   1 
ATOM   783  C CB  . ARG A 1 105 ? -3.88065  -9.32444  11.92222  1.000 44.57399 ? 105 ARG A CB  1 
ATOM   784  C CG  . ARG A 1 105 ? -3.88941  -9.51231  10.42758  1.000 46.06445 ? 105 ARG A CG  1 
ATOM   785  C CD  . ARG A 1 105 ? -2.59163  -9.00468  9.85064   1.000 39.42973 ? 105 ARG A CD  1 
ATOM   786  N NE  . ARG A 1 105 ? -2.54985  -9.20442  8.40900   1.000 44.84987 ? 105 ARG A NE  1 
ATOM   787  C CZ  . ARG A 1 105 ? -2.81102  -8.26133  7.51592   1.000 40.77528 ? 105 ARG A CZ  1 
ATOM   788  N NH1 . ARG A 1 105 ? -3.08373  -7.01855  7.88466   1.000 40.82119 ? 105 ARG A NH1 1 
ATOM   789  N NH2 . ARG A 1 105 ? -2.81533  -8.57782  6.22421   1.000 32.35297 ? 105 ARG A NH2 1 
ATOM   790  N N   . ILE A 1 106 ? -7.00457  -10.75224 11.61977  1.000 44.58473 ? 106 ILE A N   1 
ATOM   791  C CA  . ILE A 1 106 ? -7.74026  -11.99363 11.43394  1.000 49.48989 ? 106 ILE A CA  1 
ATOM   792  C C   . ILE A 1 106 ? -7.18277  -12.72561 10.22339  1.000 48.59320 ? 106 ILE A C   1 
ATOM   793  O O   . ILE A 1 106 ? -6.51504  -12.14781 9.35937   1.000 43.90556 ? 106 ILE A O   1 
ATOM   794  C CB  . ILE A 1 106 ? -9.26596  -11.78188 11.30234  1.000 46.56439 ? 106 ILE A CB  1 
ATOM   795  C CG1 . ILE A 1 106 ? -9.60012  -10.62156 10.37124  1.000 47.15324 ? 106 ILE A CG1 1 
ATOM   796  C CG2 . ILE A 1 106 ? -9.89342  -11.58271 12.65985  1.000 54.10216 ? 106 ILE A CG2 1 
ATOM   797  C CD1 . ILE A 1 106 ? -9.32153  -10.90066 8.91269   1.000 50.64364 ? 106 ILE A CD1 1 
ATOM   798  N N   . GLN A 1 107 ? -7.46480  -14.01326 10.16685  1.000 45.65953 ? 107 GLN A N   1 
ATOM   799  C CA  . GLN A 1 107 ? -7.07826  -14.95316 9.12878   1.000 46.20422 ? 107 GLN A CA  1 
ATOM   800  C C   . GLN A 1 107 ? -8.17822  -15.08456 8.08514   1.000 44.37584 ? 107 GLN A C   1 
ATOM   801  O O   . GLN A 1 107 ? -9.36095  -14.88969 8.38509   1.000 44.33368 ? 107 GLN A O   1 
ATOM   802  C CB  . GLN A 1 107 ? -6.78749  -16.32095 9.73466   1.000 51.07882 ? 107 GLN A CB  1 
ATOM   803  C CG  . GLN A 1 107 ? -5.60668  -16.29881 10.67747  1.000 56.15982 ? 107 GLN A CG  1 
ATOM   804  C CD  . GLN A 1 107 ? -4.35650  -15.88653 9.94969   1.000 53.61923 ? 107 GLN A CD  1 
ATOM   805  O OE1 . GLN A 1 107 ? -4.16541  -16.24962 8.78815   1.000 58.65691 ? 107 GLN A OE1 1 
ATOM   806  N NE2 . GLN A 1 107 ? -3.51161  -15.09726 10.60648  1.000 55.72974 ? 107 GLN A NE2 1 
ATOM   807  N N   . PRO A 1 108 ? -7.79276  -15.40143 6.85477   1.000 48.60992 ? 108 PRO A N   1 
ATOM   808  C CA  . PRO A 1 108 ? -8.79512  -15.64730 5.81399   1.000 47.07692 ? 108 PRO A CA  1 
ATOM   809  C C   . PRO A 1 108 ? -9.73926  -16.76422 6.24064   1.000 43.16387 ? 108 PRO A C   1 
ATOM   810  O O   . PRO A 1 108 ? -9.31237  -17.81069 6.73704   1.000 43.28745 ? 108 PRO A O   1 
ATOM   811  C CB  . PRO A 1 108 ? -7.95533  -16.04197 4.59423   1.000 47.22378 ? 108 PRO A CB  1 
ATOM   812  C CG  . PRO A 1 108 ? -6.57995  -15.45619 4.87470   1.000 50.25845 ? 108 PRO A CG  1 
ATOM   813  C CD  . PRO A 1 108 ? -6.41073  -15.54995 6.36413   1.000 44.86541 ? 108 PRO A CD  1 
ATOM   814  N N   . GLY A 1 109 ? -11.03281 -16.52679 6.04340   1.000 44.32068 ? 109 GLY A N   1 
ATOM   815  C CA  . GLY A 1 109 ? -12.06599 -17.46425 6.42662   1.000 44.55626 ? 109 GLY A CA  1 
ATOM   816  C C   . GLY A 1 109 ? -12.72926 -17.15623 7.74877   1.000 46.69714 ? 109 GLY A C   1 
ATOM   817  O O   . GLY A 1 109 ? -13.78945 -17.72642 8.03507   1.000 43.69894 ? 109 GLY A O   1 
ATOM   818  N N   . GLN A 1 110 ? -12.13886 -16.28508 8.56764   1.000 43.75921 ? 110 GLN A N   1 
ATOM   819  C CA  . GLN A 1 110 ? -12.77485 -15.90916 9.82201   1.000 43.44058 ? 110 GLN A CA  1 
ATOM   820  C C   . GLN A 1 110 ? -13.81280 -14.82233 9.56913   1.000 41.82981 ? 110 GLN A C   1 
ATOM   821  O O   . GLN A 1 110 ? -13.82287 -14.17917 8.52014   1.000 44.22609 ? 110 GLN A O   1 
ATOM   822  C CB  . GLN A 1 110 ? -11.74068 -15.43347 10.83984  1.000 39.95644 ? 110 GLN A CB  1 
ATOM   823  C CG  . GLN A 1 110 ? -10.82664 -16.53884 11.31635  1.000 44.99348 ? 110 GLN A CG  1 
ATOM   824  C CD  . GLN A 1 110 ? -11.58961 -17.76256 11.81401  1.000 56.23913 ? 110 GLN A CD  1 
ATOM   825  O OE1 . GLN A 1 110 ? -12.16298 -17.74895 12.90682  1.000 62.53875 ? 110 GLN A OE1 1 
ATOM   826  N NE2 . GLN A 1 110 ? -11.60293 -18.82748 11.00879  1.000 49.55448 ? 110 GLN A NE2 1 
ATOM   827  N N   . THR A 1 111 ? -14.71763 -14.64563 10.53133  1.000 43.10366 ? 111 THR A N   1 
ATOM   828  C CA  . THR A 1 111 ? -15.81479 -13.70306 10.38330  1.000 36.89158 ? 111 THR A CA  1 
ATOM   829  C C   . THR A 1 111 ? -15.69535 -12.58143 11.40538  1.000 37.56159 ? 111 THR A C   1 
ATOM   830  O O   . THR A 1 111 ? -15.00367 -12.69732 12.42178  1.000 37.89315 ? 111 THR A O   1 
ATOM   831  C CB  . THR A 1 111 ? -17.18154 -14.40157 10.54297  1.000 39.77136 ? 111 THR A CB  1 
ATOM   832  O OG1 . THR A 1 111 ? -17.25596 -15.02938 11.82911  1.000 37.98977 ? 111 THR A OG1 1 
ATOM   833  C CG2 . THR A 1 111 ? -17.37960 -15.42984 9.46783   1.000 37.58179 ? 111 THR A CG2 1 
ATOM   834  N N   . PHE A 1 112 ? -16.41748 -11.49832 11.14327  1.000 37.86302 ? 112 PHE A N   1 
ATOM   835  C CA  . PHE A 1 112 ? -16.47348 -10.39373 12.09290  1.000 41.98875 ? 112 PHE A CA  1 
ATOM   836  C C   . PHE A 1 112 ? -17.69558 -9.53820  11.79094  1.000 37.42338 ? 112 PHE A C   1 
ATOM   837  O O   . PHE A 1 112 ? -18.31223 -9.63595  10.72578  1.000 35.90157 ? 112 PHE A O   1 
ATOM   838  C CB  . PHE A 1 112 ? -15.17677 -9.54669  12.07894  1.000 36.11225 ? 112 PHE A CB  1 
ATOM   839  C CG  . PHE A 1 112 ? -14.78205 -9.03107  10.72628  1.000 41.35104 ? 112 PHE A CG  1 
ATOM   840  C CD1 . PHE A 1 112 ? -13.96872 -9.78827  9.88822   1.000 42.30974 ? 112 PHE A CD1 1 
ATOM   841  C CD2 . PHE A 1 112 ? -15.18103 -7.76151  10.30125  1.000 38.83216 ? 112 PHE A CD2 1 
ATOM   842  C CE1 . PHE A 1 112 ? -13.58161 -9.30321  8.63714   1.000 44.73606 ? 112 PHE A CE1 1 
ATOM   843  C CE2 . PHE A 1 112 ? -14.80644 -7.28078  9.06229   1.000 42.27923 ? 112 PHE A CE2 1 
ATOM   844  C CZ  . PHE A 1 112 ? -14.00172 -8.04375  8.22516   1.000 40.71857 ? 112 PHE A CZ  1 
ATOM   845  N N   . SER A 1 113 ? -18.06295 -8.72906  12.76747  1.000 33.98668 ? 113 SER A N   1 
ATOM   846  C CA  . SER A 1 113 ? -19.15515 -7.78929  12.59508  1.000 37.81765 ? 113 SER A CA  1 
ATOM   847  C C   . SER A 1 113 ? -18.59320 -6.47001  12.08183  1.000 37.88045 ? 113 SER A C   1 
ATOM   848  O O   . SER A 1 113 ? -17.53296 -6.04221  12.52433  1.000 36.81476 ? 113 SER A O   1 
ATOM   849  C CB  . SER A 1 113 ? -19.87361 -7.55467  13.91701  1.000 39.83853 ? 113 SER A CB  1 
ATOM   850  O OG  . SER A 1 113 ? -20.38350 -8.76996  14.43072  1.000 39.46082 ? 113 SER A OG  1 
ATOM   851  N N   . VAL A 1 114 ? -19.32355 -5.83043  11.16962  1.000 35.69496 ? 114 VAL A N   1 
ATOM   852  C CA  . VAL A 1 114 ? -18.99546 -4.50364  10.65806  1.000 40.30023 ? 114 VAL A CA  1 
ATOM   853  C C   . VAL A 1 114 ? -20.06781 -3.54464  11.14234  1.000 41.11331 ? 114 VAL A C   1 
ATOM   854  O O   . VAL A 1 114 ? -21.26958 -3.82029  11.00165  1.000 36.60273 ? 114 VAL A O   1 
ATOM   855  C CB  . VAL A 1 114 ? -18.90650 -4.48259  9.12260   1.000 36.26833 ? 114 VAL A CB  1 
ATOM   856  C CG1 . VAL A 1 114 ? -18.77741 -3.05323  8.62248   1.000 39.87073 ? 114 VAL A CG1 1 
ATOM   857  C CG2 . VAL A 1 114 ? -17.74160 -5.34602  8.64018   1.000 36.99579 ? 114 VAL A CG2 1 
ATOM   858  N N   . LEU A 1 115 ? -19.63270 -2.43260  11.73004  1.000 39.07745 ? 115 LEU A N   1 
ATOM   859  C CA  . LEU A 1 115 ? -20.52273 -1.34952  12.12405  1.000 36.06722 ? 115 LEU A CA  1 
ATOM   860  C C   . LEU A 1 115 ? -20.36760 -0.26407  11.06657  1.000 40.92293 ? 115 LEU A C   1 
ATOM   861  O O   . LEU A 1 115 ? -19.41892 0.53260   11.10274  1.000 39.58196 ? 115 LEU A O   1 
ATOM   862  C CB  . LEU A 1 115 ? -20.19204 -0.84915  13.52277  1.000 36.81036 ? 115 LEU A CB  1 
ATOM   863  C CG  . LEU A 1 115 ? -21.17943 0.18886   14.05129  1.000 34.46571 ? 115 LEU A CG  1 
ATOM   864  C CD1 . LEU A 1 115 ? -22.51483 -0.47086  14.46025  1.000 41.47458 ? 115 LEU A CD1 1 
ATOM   865  C CD2 . LEU A 1 115 ? -20.59017 0.95412   15.20880  1.000 40.10075 ? 115 LEU A CD2 1 
ATOM   866  N N   . ALA A 1 116 ? -21.25945 -0.28152  10.08293  1.000 39.00317 ? 116 ALA A N   1 
ATOM   867  C CA  . ALA A 1 116 ? -21.22833 0.73514   9.05266   1.000 38.58789 ? 116 ALA A CA  1 
ATOM   868  C C   . ALA A 1 116 ? -21.54424 2.08336   9.68426   1.000 41.63173 ? 116 ALA A C   1 
ATOM   869  O O   . ALA A 1 116 ? -22.51218 2.20970   10.43755  1.000 42.91631 ? 116 ALA A O   1 
ATOM   870  C CB  . ALA A 1 116 ? -22.22442 0.40609   7.94418   1.000 36.16605 ? 116 ALA A CB  1 
ATOM   871  N N   . CYS A 1 117 ? -20.74186 3.09395   9.34954   1.000 40.00643 ? 117 CYS A N   1 
ATOM   872  C CA  A CYS A 1 117 ? -20.83308 4.41041   9.96629   0.500 40.35509 ? 117 CYS A CA  1 
ATOM   873  C CA  B CYS A 1 117 ? -20.80932 4.40214   9.97692   0.500 40.43288 ? 117 CYS A CA  1 
ATOM   874  C C   . CYS A 1 117 ? -20.66482 5.49373   8.91634   1.000 37.23161 ? 117 CYS A C   1 
ATOM   875  O O   . CYS A 1 117 ? -19.99781 5.30057   7.90116   1.000 37.61645 ? 117 CYS A O   1 
ATOM   876  C CB  A CYS A 1 117 ? -19.77194 4.63348   11.03709  0.500 39.95576 ? 117 CYS A CB  1 
ATOM   877  C CB  B CYS A 1 117 ? -19.71434 4.50637   11.04101  0.500 39.97037 ? 117 CYS A CB  1 
ATOM   878  S SG  A CYS A 1 117 ? -19.93081 3.58876   12.45050  0.500 36.13462 ? 117 CYS A SG  1 
ATOM   879  S SG  B CYS A 1 117 ? -19.94410 5.75932   12.27792  0.500 42.68953 ? 117 CYS A SG  1 
ATOM   880  N N   . TYR A 1 118 ? -21.29844 6.63959   9.16439   1.000 38.46960 ? 118 TYR A N   1 
ATOM   881  C CA  . TYR A 1 118 ? -21.21969 7.81548   8.30070   1.000 45.20551 ? 118 TYR A CA  1 
ATOM   882  C C   . TYR A 1 118 ? -21.23454 9.05486   9.17649   1.000 46.48690 ? 118 TYR A C   1 
ATOM   883  O O   . TYR A 1 118 ? -22.09280 9.17343   10.05897  1.000 43.61745 ? 118 TYR A O   1 
ATOM   884  C CB  . TYR A 1 118 ? -22.37424 7.87023   7.29560   1.000 42.20959 ? 118 TYR A CB  1 
ATOM   885  C CG  . TYR A 1 118 ? -22.35985 6.68150   6.36860   1.000 46.95633 ? 118 TYR A CG  1 
ATOM   886  C CD1 . TYR A 1 118 ? -23.04004 5.50440   6.70385   1.000 46.19971 ? 118 TYR A CD1 1 
ATOM   887  C CD2 . TYR A 1 118 ? -21.63454 6.71770   5.18363   1.000 37.22668 ? 118 TYR A CD2 1 
ATOM   888  C CE1 . TYR A 1 118 ? -23.00768 4.39945   5.87598   1.000 42.44584 ? 118 TYR A CE1 1 
ATOM   889  C CE2 . TYR A 1 118 ? -21.58987 5.62677   4.33918   1.000 39.77692 ? 118 TYR A CE2 1 
ATOM   890  C CZ  . TYR A 1 118 ? -22.29102 4.46477   4.69601   1.000 44.51085 ? 118 TYR A CZ  1 
ATOM   891  O OH  . TYR A 1 118 ? -22.26849 3.36378   3.88308   1.000 39.70680 ? 118 TYR A OH  1 
ATOM   892  N N   . ASN A 1 119 ? -20.29052 9.96894   8.92943   1.000 44.19457 ? 119 ASN A N   1 
ATOM   893  C CA  . ASN A 1 119 ? -20.18472 11.21809  9.69204   1.000 49.18805 ? 119 ASN A CA  1 
ATOM   894  C C   . ASN A 1 119 ? -20.10320 10.94434  11.18813  1.000 42.43932 ? 119 ASN A C   1 
ATOM   895  O O   . ASN A 1 119 ? -20.71222 11.63654  11.99946  1.000 46.58411 ? 119 ASN A O   1 
ATOM   896  C CB  . ASN A 1 119 ? -21.35696 12.16133  9.39261   1.000 51.35943 ? 119 ASN A CB  1 
ATOM   897  C CG  . ASN A 1 119 ? -21.43310 12.55885  7.92945   1.000 48.04585 ? 119 ASN A CG  1 
ATOM   898  O OD1 . ASN A 1 119 ? -22.27291 12.04842  7.18462   1.000 55.33050 ? 119 ASN A OD1 1 
ATOM   899  N ND2 . ASN A 1 119 ? -20.56126 13.47249  7.50974   1.000 53.17391 ? 119 ASN A ND2 1 
ATOM   900  N N   . GLY A 1 120 ? -19.36176 9.90756   11.55787  1.000 43.34000 ? 120 GLY A N   1 
ATOM   901  C CA  . GLY A 1 120 ? -19.28688 9.50383   12.94690  1.000 44.98691 ? 120 GLY A CA  1 
ATOM   902  C C   . GLY A 1 120 ? -20.52993 8.86163   13.54515  1.000 47.47700 ? 120 GLY A C   1 
ATOM   903  O O   . GLY A 1 120 ? -20.51293 8.53961   14.73996  1.000 47.11897 ? 120 GLY A O   1 
ATOM   904  N N   . SER A 1 121 ? -21.60765 8.66134   12.77986  1.000 42.82947 ? 121 SER A N   1 
ATOM   905  C CA  . SER A 1 121 ? -22.84480 8.10063   13.33690  1.000 47.24195 ? 121 SER A CA  1 
ATOM   906  C C   . SER A 1 121 ? -23.07514 6.65912   12.89005  1.000 44.73045 ? 121 SER A C   1 
ATOM   907  O O   . SER A 1 121 ? -23.23079 6.42415   11.68090  1.000 42.89465 ? 121 SER A O   1 
ATOM   908  C CB  . SER A 1 121 ? -24.03490 8.95915   12.92235  1.000 49.15107 ? 121 SER A CB  1 
ATOM   909  O OG  . SER A 1 121 ? -24.08300 10.15103  13.66693  1.000 61.16290 ? 121 SER A OG  1 
ATOM   910  N N   . PRO A 1 122 ? -23.15215 5.67535   13.79848  1.000 47.23998 ? 122 PRO A N   1 
ATOM   911  C CA  . PRO A 1 122 ? -23.47870 4.30877   13.37028  1.000 44.70460 ? 122 PRO A CA  1 
ATOM   912  C C   . PRO A 1 122 ? -24.76174 4.26268   12.55549  1.000 42.74581 ? 122 PRO A C   1 
ATOM   913  O O   . PRO A 1 122 ? -25.76482 4.89805   12.88410  1.000 44.40609 ? 122 PRO A O   1 
ATOM   914  C CB  . PRO A 1 122 ? -23.61174 3.54347   14.69041  1.000 43.28047 ? 122 PRO A CB  1 
ATOM   915  C CG  . PRO A 1 122 ? -22.59496 4.21319   15.56376  1.000 46.94095 ? 122 PRO A CG  1 
ATOM   916  C CD  . PRO A 1 122 ? -22.71645 5.70485   15.20687  1.000 38.40039 ? 122 PRO A CD  1 
ATOM   917  N N   . SER A 1 123 ? -24.70550 3.49317   11.47806  1.000 42.57285 ? 123 SER A N   1 
ATOM   918  C CA  . SER A 1 123 ? -25.77700 3.32998   10.50786  1.000 42.65570 ? 123 SER A CA  1 
ATOM   919  C C   . SER A 1 123 ? -26.38693 1.93372   10.49850  1.000 41.21965 ? 123 SER A C   1 
ATOM   920  O O   . SER A 1 123 ? -27.57500 1.79510   10.19847  1.000 42.41928 ? 123 SER A O   1 
ATOM   921  C CB  . SER A 1 123 ? -25.23071 3.62394   9.10934   1.000 39.79034 ? 123 SER A CB  1 
ATOM   922  O OG  . SER A 1 123 ? -26.21071 3.47080   8.10831   1.000 55.98191 ? 123 SER A OG  1 
ATOM   923  N N   . GLY A 1 124 ? -25.59475 0.89898   10.75983  1.000 36.99399 ? 124 GLY A N   1 
ATOM   924  C CA  . GLY A 1 124 ? -26.08648 -0.47351  10.66090  1.000 39.55931 ? 124 GLY A CA  1 
ATOM   925  C C   . GLY A 1 124 ? -24.98342 -1.44156  11.03026  1.000 42.09926 ? 124 GLY A C   1 
ATOM   926  O O   . GLY A 1 124 ? -23.81634 -1.06319  11.17597  1.000 41.47844 ? 124 GLY A O   1 
ATOM   927  N N   . VAL A 1 125 ? -25.36480 -2.71310  11.17115  1.000 40.29054 ? 125 VAL A N   1 
ATOM   928  C CA  . VAL A 1 125 ? -24.42700 -3.75109  11.58745  1.000 40.49548 ? 125 VAL A CA  1 
ATOM   929  C C   . VAL A 1 125 ? -24.74467 -5.05459  10.86300  1.000 40.35355 ? 125 VAL A C   1 
ATOM   930  O O   . VAL A 1 125 ? -25.91112 -5.43937  10.73573  1.000 43.89064 ? 125 VAL A O   1 
ATOM   931  C CB  . VAL A 1 125 ? -24.45779 -3.94533  13.11754  1.000 39.32809 ? 125 VAL A CB  1 
ATOM   932  C CG1 . VAL A 1 125 ? -25.76969 -4.48661  13.53748  1.000 42.66282 ? 125 VAL A CG1 1 
ATOM   933  C CG2 . VAL A 1 125 ? -23.33245 -4.86512  13.55896  1.000 37.42512 ? 125 VAL A CG2 1 
ATOM   934  N N   . TYR A 1 126 ? -23.69805 -5.74010  10.39856  1.000 41.01702 ? 126 TYR A N   1 
ATOM   935  C CA  . TYR A 1 126 ? -23.83842 -6.97945  9.64262   1.000 42.19513 ? 126 TYR A CA  1 
ATOM   936  C C   . TYR A 1 126 ? -22.54842 -7.77722  9.76948   1.000 40.03000 ? 126 TYR A C   1 
ATOM   937  O O   . TYR A 1 126 ? -21.51896 -7.25770  10.19897  1.000 37.92568 ? 126 TYR A O   1 
ATOM   938  C CB  . TYR A 1 126 ? -24.16972 -6.71559  8.16814   1.000 36.53642 ? 126 TYR A CB  1 
ATOM   939  C CG  . TYR A 1 126 ? -23.19616 -5.80718  7.46602   1.000 40.33791 ? 126 TYR A CG  1 
ATOM   940  C CD1 . TYR A 1 126 ? -22.05978 -6.32370  6.86493   1.000 43.40492 ? 126 TYR A CD1 1 
ATOM   941  C CD2 . TYR A 1 126 ? -23.41206 -4.43480  7.39457   1.000 41.22149 ? 126 TYR A CD2 1 
ATOM   942  C CE1 . TYR A 1 126 ? -21.16716 -5.51880  6.21117   1.000 38.02435 ? 126 TYR A CE1 1 
ATOM   943  C CE2 . TYR A 1 126 ? -22.50190 -3.59659  6.73610   1.000 39.99526 ? 126 TYR A CE2 1 
ATOM   944  C CZ  . TYR A 1 126 ? -21.38155 -4.15471  6.15014   1.000 41.30731 ? 126 TYR A CZ  1 
ATOM   945  O OH  . TYR A 1 126 ? -20.45761 -3.36439  5.48734   1.000 45.52372 ? 126 TYR A OH  1 
ATOM   946  N N   . GLN A 1 127 ? -22.62552 -9.05100  9.37204   1.000 40.06018 ? 127 GLN A N   1 
ATOM   947  C CA  . GLN A 1 127 ? -21.54211 -10.02348 9.48569   1.000 37.57990 ? 127 GLN A CA  1 
ATOM   948  C C   . GLN A 1 127 ? -20.81334 -10.16247 8.16701   1.000 38.94830 ? 127 GLN A C   1 
ATOM   949  O O   . GLN A 1 127 ? -21.44179 -10.20030 7.10985   1.000 43.09268 ? 127 GLN A O   1 
ATOM   950  C CB  . GLN A 1 127 ? -22.08030 -11.40970 9.87650   1.000 40.41106 ? 127 GLN A CB  1 
ATOM   951  C CG  . GLN A 1 127 ? -22.31109 -11.60105 11.32424  1.000 41.03242 ? 127 GLN A CG  1 
ATOM   952  C CD  . GLN A 1 127 ? -21.02445 -11.56769 12.11064  1.000 41.85648 ? 127 GLN A CD  1 
ATOM   953  O OE1 . GLN A 1 127 ? -20.75398 -10.60685 12.81521  1.000 44.18797 ? 127 GLN A OE1 1 
ATOM   954  N NE2 . GLN A 1 127 ? -20.23313 -12.63046 12.01442  1.000 42.81599 ? 127 GLN A NE2 1 
ATOM   955  N N   . CYS A 1 128 ? -19.48889 -10.28818 8.24294   1.000 35.54098 ? 128 CYS A N   1 
ATOM   956  C CA  . CYS A 1 128 ? -18.61858 -10.42919 7.08866   1.000 43.87095 ? 128 CYS A CA  1 
ATOM   957  C C   . CYS A 1 128 ? -17.65028 -11.56057 7.35388   1.000 42.31827 ? 128 CYS A C   1 
ATOM   958  O O   . CYS A 1 128 ? -17.27174 -11.82693 8.50142   1.000 44.12681 ? 128 CYS A O   1 
ATOM   959  C CB  . CYS A 1 128 ? -17.78873 -9.12455  6.77579   1.000 33.45356 ? 128 CYS A CB  1 
ATOM   960  S SG  . CYS A 1 128 ? -18.78470 -8.00887  5.84737   1.000 47.92896 ? 128 CYS A SG  1 
ATOM   961  N N   . ALA A 1 129 ? -17.23790 -12.20796 6.28169   1.000 41.72623 ? 129 ALA A N   1 
ATOM   962  C CA  . ALA A 1 129 ? -16.07536 -13.07170 6.32394   1.000 41.94696 ? 129 ALA A CA  1 
ATOM   963  C C   . ALA A 1 129 ? -14.95095 -12.39985 5.55731   1.000 40.12862 ? 129 ALA A C   1 
ATOM   964  O O   . ALA A 1 129 ? -15.19742 -11.70276 4.57351   1.000 39.82937 ? 129 ALA A O   1 
ATOM   965  C CB  . ALA A 1 129 ? -16.37904 -14.44486 5.72578   1.000 37.44455 ? 129 ALA A CB  1 
ATOM   966  N N   . MET A 1 130 ? -13.72168 -12.60826 6.01254   1.000 38.41174 ? 130 MET A N   1 
ATOM   967  C CA  . MET A 1 130 ? -12.53908 -12.22506 5.24270   1.000 41.88187 ? 130 MET A CA  1 
ATOM   968  C C   . MET A 1 130 ? -12.32969 -13.28465 4.16857   1.000 41.95320 ? 130 MET A C   1 
ATOM   969  O O   . MET A 1 130 ? -11.97474 -14.42418 4.48212   1.000 43.53543 ? 130 MET A O   1 
ATOM   970  C CB  . MET A 1 130 ? -11.33061 -12.10667 6.16702   1.000 41.01698 ? 130 MET A CB  1 
ATOM   971  C CG  . MET A 1 130 ? -9.99928  -11.84519 5.47198   1.000 43.90990 ? 130 MET A CG  1 
ATOM   972  S SD  . MET A 1 130 ? -9.91171  -10.18120 4.78180   1.000 44.16511 ? 130 MET A SD  1 
ATOM   973  C CE  . MET A 1 130 ? -10.23348 -9.23133  6.26620   1.000 38.53947 ? 130 MET A CE  1 
ATOM   974  N N   . ARG A 1 131 ? -12.59894 -12.93882 2.90646   1.000 40.08286 ? 131 ARG A N   1 
ATOM   975  C CA  . ARG A 1 131 ? -12.49626 -13.92551 1.84761   1.000 40.76090 ? 131 ARG A CA  1 
ATOM   976  C C   . ARG A 1 131 ? -11.05823 -14.43700 1.73083   1.000 42.93044 ? 131 ARG A C   1 
ATOM   977  O O   . ARG A 1 131 ? -10.12399 -13.84009 2.27477   1.000 42.35893 ? 131 ARG A O   1 
ATOM   978  C CB  . ARG A 1 131 ? -12.95721 -13.35046 0.51016   1.000 33.36801 ? 131 ARG A CB  1 
ATOM   979  C CG  . ARG A 1 131 ? -14.35956 -12.75702 0.50165   1.000 38.38605 ? 131 ARG A CG  1 
ATOM   980  C CD  . ARG A 1 131 ? -15.44790 -13.76526 0.93286   1.000 40.14103 ? 131 ARG A CD  1 
ATOM   981  N NE  . ARG A 1 131 ? -15.34922 -15.05248 0.24998   1.000 39.88700 ? 131 ARG A NE  1 
ATOM   982  C CZ  . ARG A 1 131 ? -16.06981 -16.13230 0.55143   1.000 47.19946 ? 131 ARG A CZ  1 
ATOM   983  N NH1 . ARG A 1 131 ? -16.96706 -16.12313 1.52663   1.000 39.32309 ? 131 ARG A NH1 1 
ATOM   984  N NH2 . ARG A 1 131 ? -15.88256 -17.25242 -0.14223  1.000 40.67721 ? 131 ARG A NH2 1 
ATOM   985  N N   . PRO A 1 132 ? -10.86546 -15.57301 1.05484   1.000 43.64608 ? 132 PRO A N   1 
ATOM   986  C CA  . PRO A 1 132 ? -9.49578  -16.06326 0.85298   1.000 44.43370 ? 132 PRO A CA  1 
ATOM   987  C C   . PRO A 1 132 ? -8.65065  -15.10177 0.02994   1.000 43.59302 ? 132 PRO A C   1 
ATOM   988  O O   . PRO A 1 132 ? -7.42092  -15.09835 0.16236   1.000 43.46640 ? 132 PRO A O   1 
ATOM   989  C CB  . PRO A 1 132 ? -9.71193  -17.40540 0.14558   1.000 47.05769 ? 132 PRO A CB  1 
ATOM   990  C CG  . PRO A 1 132 ? -11.10847 -17.84581 0.62714   1.000 46.03409 ? 132 PRO A CG  1 
ATOM   991  C CD  . PRO A 1 132 ? -11.87798 -16.54636 0.61415   1.000 46.21862 ? 132 PRO A CD  1 
ATOM   992  N N   . ASN A 1 133 ? -9.28014  -14.27844 -0.81028  1.000 40.56869 ? 133 ASN A N   1 
ATOM   993  C CA  . ASN A 1 133 ? -8.59258  -13.24716 -1.56005  1.000 41.48278 ? 133 ASN A CA  1 
ATOM   994  C C   . ASN A 1 133 ? -8.50917  -11.91831 -0.80721  1.000 43.58108 ? 133 ASN A C   1 
ATOM   995  O O   . ASN A 1 133 ? -8.26410  -10.88266 -1.43581  1.000 42.07702 ? 133 ASN A O   1 
ATOM   996  C CB  . ASN A 1 133 ? -9.27016  -13.05521 -2.92088  1.000 41.12160 ? 133 ASN A CB  1 
ATOM   997  C CG  . ASN A 1 133 ? -10.63370 -12.40892 -2.81478  1.000 39.57415 ? 133 ASN A CG  1 
ATOM   998  O OD1 . ASN A 1 133 ? -11.10620 -12.07971 -1.71797  1.000 39.65404 ? 133 ASN A OD1 1 
ATOM   999  N ND2 . ASN A 1 133 ? -11.28560 -12.23043 -3.96104  1.000 41.84051 ? 133 ASN A ND2 1 
ATOM   1000 N N   . PHE A 1 134 ? -8.75095  -11.91272 0.50580   1.000 42.25940 ? 134 PHE A N   1 
ATOM   1001 C CA  . PHE A 1 134 ? -8.50172  -10.74907 1.36487   1.000 41.84540 ? 134 PHE A CA  1 
ATOM   1002 C C   . PHE A 1 134 ? -9.40401  -9.54957  1.05968   1.000 42.36734 ? 134 PHE A C   1 
ATOM   1003 O O   . PHE A 1 134 ? -9.04782  -8.41306  1.38900   1.000 48.36733 ? 134 PHE A O   1 
ATOM   1004 C CB  . PHE A 1 134 ? -7.03375  -10.31030 1.27942   1.000 41.59810 ? 134 PHE A CB  1 
ATOM   1005 C CG  . PHE A 1 134 ? -6.08146  -11.33740 1.77042   1.000 41.24075 ? 134 PHE A CG  1 
ATOM   1006 C CD1 . PHE A 1 134 ? -5.83897  -11.47110 3.12486   1.000 40.11358 ? 134 PHE A CD1 1 
ATOM   1007 C CD2 . PHE A 1 134 ? -5.43813  -12.18675 0.88388   1.000 44.50983 ? 134 PHE A CD2 1 
ATOM   1008 C CE1 . PHE A 1 134 ? -4.96466  -12.43310 3.59412   1.000 43.92831 ? 134 PHE A CE1 1 
ATOM   1009 C CE2 . PHE A 1 134 ? -4.55856  -13.15613 1.34922   1.000 45.30581 ? 134 PHE A CE2 1 
ATOM   1010 C CZ  . PHE A 1 134 ? -4.32951  -13.27661 2.70369   1.000 46.47706 ? 134 PHE A CZ  1 
ATOM   1011 N N   . THR A 1 135 ? -10.53227 -9.75504  0.39364   1.000 40.74648 ? 135 THR A N   1 
ATOM   1012 C CA  . THR A 1 135 ? -11.58548 -8.75829  0.29213   1.000 38.82510 ? 135 THR A CA  1 
ATOM   1013 C C   . THR A 1 135 ? -12.72172 -9.13498  1.24664   1.000 38.71253 ? 135 THR A C   1 
ATOM   1014 O O   . THR A 1 135 ? -12.76528 -10.23617 1.80841   1.000 39.14895 ? 135 THR A O   1 
ATOM   1015 C CB  . THR A 1 135 ? -12.10014 -8.65837  -1.15237  1.000 36.68596 ? 135 THR A CB  1 
ATOM   1016 O OG1 . THR A 1 135 ? -12.79798 -9.85515  -1.51272  1.000 40.39841 ? 135 THR A OG1 1 
ATOM   1017 C CG2 . THR A 1 135 ? -10.94764 -8.46890  -2.13353  1.000 44.74295 ? 135 THR A CG2 1 
ATOM   1018 N N   . ILE A 1 136 ? -13.66335 -8.21989  1.41758   1.000 37.29328 ? 136 ILE A N   1 
ATOM   1019 C CA  . ILE A 1 136 ? -14.90941 -8.56059  2.09147   1.000 37.18468 ? 136 ILE A CA  1 
ATOM   1020 C C   . ILE A 1 136 ? -16.05500 -8.13593  1.19572   1.000 40.13342 ? 136 ILE A C   1 
ATOM   1021 O O   . ILE A 1 136 ? -15.95371 -7.16569  0.44309   1.000 36.89397 ? 136 ILE A O   1 
ATOM   1022 C CB  . ILE A 1 136 ? -15.04873 -7.91803  3.48195   1.000 41.12468 ? 136 ILE A CB  1 
ATOM   1023 C CG1 . ILE A 1 136 ? -14.90856 -6.39420  3.39282   1.000 41.94364 ? 136 ILE A CG1 1 
ATOM   1024 C CG2 . ILE A 1 136 ? -14.03492 -8.52195  4.44695   1.000 45.12320 ? 136 ILE A CG2 1 
ATOM   1025 C CD1 . ILE A 1 136 ? -15.15314 -5.70252  4.72149   1.000 35.39687 ? 136 ILE A CD1 1 
ATOM   1026 N N   . LYS A 1 137 ? -17.15741 -8.87806  1.27603   1.000 41.79427 ? 137 LYS A N   1 
ATOM   1027 C CA  . LYS A 1 137 ? -18.36477 -8.50454  0.55204   1.000 38.55174 ? 137 LYS A CA  1 
ATOM   1028 C C   . LYS A 1 137 ? -19.19486 -7.71070  1.54702   1.000 41.15505 ? 137 LYS A C   1 
ATOM   1029 O O   . LYS A 1 137 ? -19.98842 -8.25991  2.32439   1.000 38.43811 ? 137 LYS A O   1 
ATOM   1030 C CB  . LYS A 1 137 ? -19.08309 -9.73417  0.01351   1.000 45.38645 ? 137 LYS A CB  1 
ATOM   1031 C CG  . LYS A 1 137 ? -18.19880 -10.67159 -0.78592  1.000 40.81459 ? 137 LYS A CG  1 
ATOM   1032 N N   . GLY A 1 138 ? -18.97753 -6.39617  1.54082   1.000 39.60626 ? 138 GLY A N   1 
ATOM   1033 C CA  . GLY A 1 138 ? -19.59994 -5.50078  2.48574   1.000 34.54058 ? 138 GLY A CA  1 
ATOM   1034 C C   . GLY A 1 138 ? -20.67734 -4.65272  1.83999   1.000 35.77373 ? 138 GLY A C   1 
ATOM   1035 O O   . GLY A 1 138 ? -21.13165 -4.89429  0.71858   1.000 37.24437 ? 138 GLY A O   1 
ATOM   1036 N N   . SER A 1 139 ? -21.09807 -3.64353  2.58134   1.000 33.46402 ? 139 SER A N   1 
ATOM   1037 C CA  . SER A 1 139 ? -22.06780 -2.67275  2.08809   1.000 38.43821 ? 139 SER A CA  1 
ATOM   1038 C C   . SER A 1 139 ? -21.54600 -1.31956  2.55012   1.000 36.06811 ? 139 SER A C   1 
ATOM   1039 O O   . SER A 1 139 ? -21.64336 -0.98040  3.73299   1.000 38.88090 ? 139 SER A O   1 
ATOM   1040 C CB  . SER A 1 139 ? -23.46664 -2.94362  2.60924   1.000 37.46127 ? 139 SER A CB  1 
ATOM   1041 O OG  . SER A 1 139 ? -24.37734 -2.06321  1.99588   1.000 39.46365 ? 139 SER A OG  1 
ATOM   1042 N N   . PHE A 1 140 ? -20.97155 -0.57036  1.62418   1.000 38.69933 ? 140 PHE A N   1 
ATOM   1043 C CA  . PHE A 1 140 ? -20.22063 0.63418   1.97368   1.000 38.13410 ? 140 PHE A CA  1 
ATOM   1044 C C   . PHE A 1 140 ? -20.47465 1.69188   0.91839   1.000 37.81352 ? 140 PHE A C   1 
ATOM   1045 O O   . PHE A 1 140 ? -20.32096 1.41817   -0.27521  1.000 36.88299 ? 140 PHE A O   1 
ATOM   1046 C CB  . PHE A 1 140 ? -18.71747 0.36042   2.03607   1.000 35.40418 ? 140 PHE A CB  1 
ATOM   1047 C CG  . PHE A 1 140 ? -18.27498 -0.47619  3.20632   1.000 34.03744 ? 140 PHE A CG  1 
ATOM   1048 C CD1 . PHE A 1 140 ? -18.29799 0.02435   4.48785   1.000 35.04236 ? 140 PHE A CD1 1 
ATOM   1049 C CD2 . PHE A 1 140 ? -17.76712 -1.75329  3.00287   1.000 39.12685 ? 140 PHE A CD2 1 
ATOM   1050 C CE1 . PHE A 1 140 ? -17.83643 -0.73481  5.54763   1.000 36.01200 ? 140 PHE A CE1 1 
ATOM   1051 C CE2 . PHE A 1 140 ? -17.32529 -2.51522  4.05913   1.000 37.35205 ? 140 PHE A CE2 1 
ATOM   1052 C CZ  . PHE A 1 140 ? -17.34270 -2.00672  5.32349   1.000 33.21701 ? 140 PHE A CZ  1 
ATOM   1053 N N   . LEU A 1 141 ? -20.85639 2.88593   1.35110   1.000 37.25491 ? 141 LEU A N   1 
ATOM   1054 C CA  . LEU A 1 141 ? -21.01520 4.02695   0.46183   1.000 41.75032 ? 141 LEU A CA  1 
ATOM   1055 C C   . LEU A 1 141 ? -19.91985 5.06312   0.75467   1.000 42.63413 ? 141 LEU A C   1 
ATOM   1056 O O   . LEU A 1 141 ? -19.10247 4.90373   1.66722   1.000 40.29723 ? 141 LEU A O   1 
ATOM   1057 C CB  . LEU A 1 141 ? -22.41834 4.61899   0.61506   1.000 40.64415 ? 141 LEU A CB  1 
ATOM   1058 C CG  . LEU A 1 141 ? -23.58251 3.65682   0.35887   1.000 45.54538 ? 141 LEU A CG  1 
ATOM   1059 C CD1 . LEU A 1 141 ? -24.86669 4.28386   0.81103   1.000 49.28316 ? 141 LEU A CD1 1 
ATOM   1060 C CD2 . LEU A 1 141 ? -23.66580 3.28282   -1.12180  1.000 45.91702 ? 141 LEU A CD2 1 
ATOM   1061 N N   . ASN A 1 142 ? -19.87420 6.13189   -0.03978  1.000 43.95498 ? 142 ASN A N   1 
ATOM   1062 C CA  A ASN A 1 142 ? -18.94080 7.20661   0.26371   0.500 42.94109 ? 142 ASN A CA  1 
ATOM   1063 C CA  B ASN A 1 142 ? -18.93574 7.20818   0.26446   0.500 42.94321 ? 142 ASN A CA  1 
ATOM   1064 C C   . ASN A 1 142 ? -19.23366 7.75515   1.65386   1.000 42.99789 ? 142 ASN A C   1 
ATOM   1065 O O   . ASN A 1 142 ? -20.39319 7.86082   2.06601   1.000 44.45034 ? 142 ASN A O   1 
ATOM   1066 C CB  A ASN A 1 142 ? -19.02896 8.29963   -0.79691  0.500 43.55466 ? 142 ASN A CB  1 
ATOM   1067 C CB  B ASN A 1 142 ? -19.00986 8.32056   -0.78555  0.500 43.59265 ? 142 ASN A CB  1 
ATOM   1068 C CG  A ASN A 1 142 ? -18.26495 7.94116   -2.05647  0.500 45.08841 ? 142 ASN A CG  1 
ATOM   1069 C CG  B ASN A 1 142 ? -17.88613 9.36549   -0.63096  0.500 45.67289 ? 142 ASN A CG  1 
ATOM   1070 O OD1 A ASN A 1 142 ? -17.03824 8.07461   -2.11737  0.500 51.81170 ? 142 ASN A OD1 1 
ATOM   1071 O OD1 B ASN A 1 142 ? -16.84535 9.10745   -0.01338  0.500 43.32347 ? 142 ASN A OD1 1 
ATOM   1072 N ND2 A ASN A 1 142 ? -18.98491 7.47910   -3.06837  0.500 46.32227 ? 142 ASN A ND2 1 
ATOM   1073 N ND2 B ASN A 1 142 ? -18.10392 10.54892  -1.20004  0.500 42.59701 ? 142 ASN A ND2 1 
ATOM   1074 N N   . GLY A 1 143 ? -18.17817 8.05350   2.39954   1.000 43.85230 ? 143 GLY A N   1 
ATOM   1075 C CA  . GLY A 1 143 ? -18.31514 8.46142   3.78103   1.000 41.90436 ? 143 GLY A CA  1 
ATOM   1076 C C   . GLY A 1 143 ? -18.10813 7.35415   4.79420   1.000 37.38043 ? 143 GLY A C   1 
ATOM   1077 O O   . GLY A 1 143 ? -18.02917 7.64535   5.99096   1.000 39.62302 ? 143 GLY A O   1 
ATOM   1078 N N   . SER A 1 144 ? -18.00515 6.09934   4.36064   1.000 38.03121 ? 144 SER A N   1 
ATOM   1079 C CA  . SER A 1 144 ? -17.98205 4.97742   5.29950   1.000 37.44453 ? 144 SER A CA  1 
ATOM   1080 C C   . SER A 1 144 ? -16.58198 4.61201   5.77328   1.000 39.84933 ? 144 SER A C   1 
ATOM   1081 O O   . SER A 1 144 ? -16.44479 3.81801   6.71475   1.000 33.58007 ? 144 SER A O   1 
ATOM   1082 C CB  . SER A 1 144 ? -18.63363 3.74264   4.66681   1.000 39.76265 ? 144 SER A CB  1 
ATOM   1083 O OG  . SER A 1 144 ? -17.95407 3.32602   3.49448   1.000 37.67151 ? 144 SER A OG  1 
ATOM   1084 N N   . CYS A 1 145 ? -15.53706 5.16152   5.15080   1.000 37.02735 ? 145 CYS A N   1 
ATOM   1085 C CA  . CYS A 1 145 ? -14.18216 4.82343   5.57006   1.000 37.36075 ? 145 CYS A CA  1 
ATOM   1086 C C   . CYS A 1 145 ? -14.00008 5.15982   7.04300   1.000 33.48637 ? 145 CYS A C   1 
ATOM   1087 O O   . CYS A 1 145 ? -14.66582 6.04047   7.58638   1.000 38.75323 ? 145 CYS A O   1 
ATOM   1088 C CB  . CYS A 1 145 ? -13.15675 5.55030   4.69849   1.000 35.44394 ? 145 CYS A CB  1 
ATOM   1089 S SG  . CYS A 1 145 ? -13.16068 4.84643   3.04259   1.000 41.54689 ? 145 CYS A SG  1 
ATOM   1090 N N   . GLY A 1 146 ? -13.12879 4.40928   7.70873   1.000 31.53009 ? 146 GLY A N   1 
ATOM   1091 C CA  . GLY A 1 146 ? -13.04616 4.45694   9.15012   1.000 33.13260 ? 146 GLY A CA  1 
ATOM   1092 C C   . GLY A 1 146 ? -14.02162 3.53730   9.88950   1.000 33.20361 ? 146 GLY A C   1 
ATOM   1093 O O   . GLY A 1 146 ? -13.84110 3.31363   11.09043  1.000 36.41111 ? 146 GLY A O   1 
ATOM   1094 N N   . SER A 1 147 ? -15.08384 3.05535   9.23878   1.000 39.51928 ? 147 SER A N   1 
ATOM   1095 C CA  . SER A 1 147 ? -15.91751 2.01546   9.86592   1.000 35.68120 ? 147 SER A CA  1 
ATOM   1096 C C   . SER A 1 147 ? -15.05213 0.80633   10.21926  1.000 35.06505 ? 147 SER A C   1 
ATOM   1097 O O   . SER A 1 147 ? -14.11775 0.47122   9.49389   1.000 37.90089 ? 147 SER A O   1 
ATOM   1098 C CB  . SER A 1 147 ? -17.03914 1.57672   8.92354   1.000 36.23279 ? 147 SER A CB  1 
ATOM   1099 O OG  . SER A 1 147 ? -17.87394 2.64984   8.55719   1.000 36.98797 ? 147 SER A OG  1 
ATOM   1100 N N   . VAL A 1 148 ? -15.36267 0.12570   11.33808  1.000 37.32938 ? 148 VAL A N   1 
ATOM   1101 C CA  . VAL A 1 148 ? -14.47098 -0.93205  11.80993  1.000 39.50165 ? 148 VAL A CA  1 
ATOM   1102 C C   . VAL A 1 148 ? -15.21183 -2.27107  11.84705  1.000 39.53563 ? 148 VAL A C   1 
ATOM   1103 O O   . VAL A 1 148 ? -16.44014 -2.32407  11.96226  1.000 36.47332 ? 148 VAL A O   1 
ATOM   1104 C CB  . VAL A 1 148 ? -13.84730 -0.61694  13.19417  1.000 37.47410 ? 148 VAL A CB  1 
ATOM   1105 C CG1 . VAL A 1 148 ? -12.91310 0.61804   13.11949  1.000 39.28258 ? 148 VAL A CG1 1 
ATOM   1106 C CG2 . VAL A 1 148 ? -14.93173 -0.44325  14.26315  1.000 38.78056 ? 148 VAL A CG2 1 
ATOM   1107 N N   . GLY A 1 149 ? -14.44423 -3.35193  11.68777  1.000 36.18034 ? 149 GLY A N   1 
ATOM   1108 C CA  . GLY A 1 149 ? -14.92049 -4.70661  11.90668  1.000 39.01387 ? 149 GLY A CA  1 
ATOM   1109 C C   . GLY A 1 149 ? -14.33338 -5.20724  13.21177  1.000 43.32128 ? 149 GLY A C   1 
ATOM   1110 O O   . GLY A 1 149 ? -13.23666 -4.79141  13.60757  1.000 38.51430 ? 149 GLY A O   1 
ATOM   1111 N N   . PHE A 1 150 ? -15.07669 -6.09012  13.89348  1.000 35.02598 ? 150 PHE A N   1 
ATOM   1112 C CA  . PHE A 1 150 ? -14.69004 -6.50887  15.22867  1.000 40.49645 ? 150 PHE A CA  1 
ATOM   1113 C C   . PHE A 1 150 ? -15.39526 -7.81623  15.59916  1.000 43.23483 ? 150 PHE A C   1 
ATOM   1114 O O   . PHE A 1 150 ? -16.43051 -8.18203  15.03168  1.000 40.79091 ? 150 PHE A O   1 
ATOM   1115 C CB  . PHE A 1 150 ? -15.03277 -5.41969  16.25338  1.000 39.44158 ? 150 PHE A CB  1 
ATOM   1116 C CG  . PHE A 1 150 ? -16.50336 -5.13852  16.35237  1.000 35.14666 ? 150 PHE A CG  1 
ATOM   1117 C CD1 . PHE A 1 150 ? -17.14535 -4.42014  15.35664  1.000 38.40178 ? 150 PHE A CD1 1 
ATOM   1118 C CD2 . PHE A 1 150 ? -17.24876 -5.61614  17.42172  1.000 44.18447 ? 150 PHE A CD2 1 
ATOM   1119 C CE1 . PHE A 1 150 ? -18.51039 -4.15890  15.42454  1.000 39.61120 ? 150 PHE A CE1 1 
ATOM   1120 C CE2 . PHE A 1 150 ? -18.62429 -5.36745  17.50647  1.000 43.84595 ? 150 PHE A CE2 1 
ATOM   1121 C CZ  . PHE A 1 150 ? -19.25359 -4.63570  16.50504  1.000 45.62716 ? 150 PHE A CZ  1 
ATOM   1122 N N   . ASN A 1 151 ? -14.81188 -8.50550  16.57104  1.000 43.18992 ? 151 ASN A N   1 
ATOM   1123 C CA  . ASN A 1 151 ? -15.47033 -9.57097  17.30597  1.000 43.83144 ? 151 ASN A CA  1 
ATOM   1124 C C   . ASN A 1 151 ? -15.46998 -9.21325  18.78201  1.000 50.35152 ? 151 ASN A C   1 
ATOM   1125 O O   . ASN A 1 151 ? -14.71262 -8.34519  19.22861  1.000 46.96671 ? 151 ASN A O   1 
ATOM   1126 C CB  . ASN A 1 151 ? -14.76801 -10.90144 17.10032  1.000 42.84334 ? 151 ASN A CB  1 
ATOM   1127 C CG  . ASN A 1 151 ? -15.00399 -11.46963 15.71696  1.000 48.66005 ? 151 ASN A CG  1 
ATOM   1128 O OD1 . ASN A 1 151 ? -16.05838 -12.04947 15.44350  1.000 48.92709 ? 151 ASN A OD1 1 
ATOM   1129 N ND2 . ASN A 1 151 ? -14.02041 -11.32263 14.83832  1.000 40.37174 ? 151 ASN A ND2 1 
ATOM   1130 N N   . ILE A 1 152 ? -16.33688 -9.87962  19.54009  1.000 43.60081 ? 152 ILE A N   1 
ATOM   1131 C CA  . ILE A 1 152 ? -16.40573 -9.69970  20.98089  1.000 49.81355 ? 152 ILE A CA  1 
ATOM   1132 C C   . ILE A 1 152 ? -16.22246 -11.05321 21.65327  1.000 52.58474 ? 152 ILE A C   1 
ATOM   1133 O O   . ILE A 1 152 ? -16.74907 -12.06363 21.18123  1.000 54.24961 ? 152 ILE A O   1 
ATOM   1134 C CB  . ILE A 1 152 ? -17.72627 -9.03801  21.40888  1.000 43.64553 ? 152 ILE A CB  1 
ATOM   1135 C CG1 . ILE A 1 152 ? -17.90586 -7.70402  20.67653  1.000 49.47778 ? 152 ILE A CG1 1 
ATOM   1136 C CG2 . ILE A 1 152 ? -17.73720 -8.83244  22.89896  1.000 51.31341 ? 152 ILE A CG2 1 
ATOM   1137 C CD1 . ILE A 1 152 ? -19.17266 -6.95168  21.05982  1.000 54.00728 ? 152 ILE A CD1 1 
ATOM   1138 N N   . ASP A 1 153 ? -15.43801 -11.06887 22.73286  1.000 59.32181 ? 153 ASP A N   1 
ATOM   1139 C CA  . ASP A 1 153 ? -15.15222 -12.26772 23.52281  1.000 61.75635 ? 153 ASP A CA  1 
ATOM   1140 C C   . ASP A 1 153 ? -15.22787 -11.86227 24.98618  1.000 68.18191 ? 153 ASP A C   1 
ATOM   1141 O O   . ASP A 1 153 ? -14.36590 -11.11671 25.46489  1.000 69.25267 ? 153 ASP A O   1 
ATOM   1142 C CB  . ASP A 1 153 ? -13.77467 -12.84341 23.20404  1.000 61.10022 ? 153 ASP A CB  1 
ATOM   1143 C CG  . ASP A 1 153 ? -13.53466 -12.99008 21.71800  1.000 69.68891 ? 153 ASP A CG  1 
ATOM   1144 O OD1 . ASP A 1 153 ? -14.21165 -13.83948 21.09390  1.000 76.56887 ? 153 ASP A OD1 1 
ATOM   1145 O OD2 . ASP A 1 153 ? -12.68416 -12.24473 21.17013  1.000 66.32402 ? 153 ASP A OD2 1 
ATOM   1146 N N   . TYR A 1 154 ? -16.24930 -12.34649 25.69218  1.000 65.12550 ? 154 TYR A N   1 
ATOM   1147 C CA  . TYR A 1 154 ? -16.49425 -11.91743 27.06193  1.000 69.61266 ? 154 TYR A CA  1 
ATOM   1148 C C   . TYR A 1 154 ? -16.62168 -10.39758 27.11078  1.000 71.69798 ? 154 TYR A C   1 
ATOM   1149 O O   . TYR A 1 154 ? -17.60584 -9.83945  26.61174  1.000 74.41243 ? 154 TYR A O   1 
ATOM   1150 C CB  . TYR A 1 154 ? -15.38125 -12.41512 27.98898  1.000 69.32968 ? 154 TYR A CB  1 
ATOM   1151 N N   . ASP A 1 155 ? -15.63788 -9.71355  27.69767  1.000 67.01379 ? 155 ASP A N   1 
ATOM   1152 C CA  . ASP A 1 155 ? -15.68615 -8.26141  27.81073  1.000 71.10944 ? 155 ASP A CA  1 
ATOM   1153 C C   . ASP A 1 155 ? -14.83707 -7.55283  26.76003  1.000 66.63604 ? 155 ASP A C   1 
ATOM   1154 O O   . ASP A 1 155 ? -14.89663 -6.32166  26.66264  1.000 64.35585 ? 155 ASP A O   1 
ATOM   1155 C CB  . ASP A 1 155 ? -15.23668 -7.82441  29.21680  1.000 62.07924 ? 155 ASP A CB  1 
ATOM   1156 N N   . CYS A 1 156 ? -14.08348 -8.29533  25.95386  1.000 62.61517 ? 156 CYS A N   1 
ATOM   1157 C CA  . CYS A 1 156 ? -13.03010 -7.72932  25.12444  1.000 59.06393 ? 156 CYS A CA  1 
ATOM   1158 C C   . CYS A 1 156 ? -13.48141 -7.56878  23.67401  1.000 57.66002 ? 156 CYS A C   1 
ATOM   1159 O O   . CYS A 1 156 ? -13.75753 -8.56004  22.98652  1.000 53.17932 ? 156 CYS A O   1 
ATOM   1160 C CB  . CYS A 1 156 ? -11.78433 -8.60572  25.19385  1.000 56.93066 ? 156 CYS A CB  1 
ATOM   1161 S SG  . CYS A 1 156 ? -10.38110 -7.85457  24.36557  1.000 58.64650 ? 156 CYS A SG  1 
ATOM   1162 N N   . VAL A 1 157 ? -13.52873 -6.32341  23.20882  1.000 51.72710 ? 157 VAL A N   1 
ATOM   1163 C CA  . VAL A 1 157 ? -13.75562 -6.02948  21.79804  1.000 50.23257 ? 157 VAL A CA  1 
ATOM   1164 C C   . VAL A 1 157 ? -12.43441 -6.18192  21.05752  1.000 50.71242 ? 157 VAL A C   1 
ATOM   1165 O O   . VAL A 1 157 ? -11.48921 -5.43260  21.31199  1.000 46.75561 ? 157 VAL A O   1 
ATOM   1166 C CB  . VAL A 1 157 ? -14.31812 -4.61513  21.60812  1.000 46.34541 ? 157 VAL A CB  1 
ATOM   1167 C CG1 . VAL A 1 157 ? -14.34793 -4.25705  20.11562  1.000 42.96830 ? 157 VAL A CG1 1 
ATOM   1168 C CG2 . VAL A 1 157 ? -15.70219 -4.49019  22.25745  1.000 48.93430 ? 157 VAL A CG2 1 
ATOM   1169 N N   . SER A 1 158 ? -12.36679 -7.14517  20.13961  1.000 46.39462 ? 158 SER A N   1 
ATOM   1170 C CA  . SER A 1 158 ? -11.19611 -7.33998  19.28488  1.000 45.79573 ? 158 SER A CA  1 
ATOM   1171 C C   . SER A 1 158 ? -11.46125 -6.66022  17.94833  1.000 46.59870 ? 158 SER A C   1 
ATOM   1172 O O   . SER A 1 158 ? -12.21699 -7.17809  17.12186  1.000 44.56369 ? 158 SER A O   1 
ATOM   1173 C CB  . SER A 1 158 ? -10.89288 -8.82209  19.08561  1.000 47.29820 ? 158 SER A CB  1 
ATOM   1174 O OG  . SER A 1 158 ? -10.07592 -9.31908  20.12289  1.000 48.56477 ? 158 SER A OG  1 
ATOM   1175 N N   . PHE A 1 159 ? -10.82666 -5.50076  17.72828  1.000 44.06967 ? 159 PHE A N   1 
ATOM   1176 C CA  . PHE A 1 159 ? -10.92443 -4.81566  16.44553  1.000 44.05867 ? 159 PHE A CA  1 
ATOM   1177 C C   . PHE A 1 159 ? -10.00113 -5.48622  15.44504  1.000 39.24535 ? 159 PHE A C   1 
ATOM   1178 O O   . PHE A 1 159 ? -8.84010  -5.74573  15.75274  1.000 42.34399 ? 159 PHE A O   1 
ATOM   1179 C CB  . PHE A 1 159 ? -10.55656 -3.33861  16.59580  1.000 40.03386 ? 159 PHE A CB  1 
ATOM   1180 C CG  . PHE A 1 159 ? -11.48762 -2.58028  17.47309  1.000 38.20646 ? 159 PHE A CG  1 
ATOM   1181 C CD1 . PHE A 1 159 ? -12.72035 -2.16137  16.99291  1.000 35.76344 ? 159 PHE A CD1 1 
ATOM   1182 C CD2 . PHE A 1 159 ? -11.14637 -2.28402  18.78045  1.000 42.84609 ? 159 PHE A CD2 1 
ATOM   1183 C CE1 . PHE A 1 159 ? -13.58551 -1.44410  17.78145  1.000 33.95075 ? 159 PHE A CE1 1 
ATOM   1184 C CE2 . PHE A 1 159 ? -12.02258 -1.57146  19.58724  1.000 40.94650 ? 159 PHE A CE2 1 
ATOM   1185 C CZ  . PHE A 1 159 ? -13.24776 -1.15882  19.08957  1.000 39.99914 ? 159 PHE A CZ  1 
ATOM   1186 N N   . CYS A 1 160 ? -10.51779 -5.78989  14.25374  1.000 41.00451 ? 160 CYS A N   1 
ATOM   1187 C CA  . CYS A 1 160 ? -9.72556  -6.49417  13.25316  1.000 40.92329 ? 160 CYS A CA  1 
ATOM   1188 C C   . CYS A 1 160 ? -9.73686  -5.85902  11.87248  1.000 36.21171 ? 160 CYS A C   1 
ATOM   1189 O O   . CYS A 1 160 ? -8.93682  -6.27640  11.02660  1.000 39.76688 ? 160 CYS A O   1 
ATOM   1190 C CB  . CYS A 1 160 ? -10.20840 -7.95620  13.11300  1.000 42.23812 ? 160 CYS A CB  1 
ATOM   1191 S SG  . CYS A 1 160 ? -11.92854 -8.06977  12.55670  1.000 42.08908 ? 160 CYS A SG  1 
ATOM   1192 N N   . TYR A 1 161 ? -10.61502 -4.89075  11.60402  1.000 36.83588 ? 161 TYR A N   1 
ATOM   1193 C CA  . TYR A 1 161 ? -10.72162 -4.31525  10.26903  1.000 40.56114 ? 161 TYR A CA  1 
ATOM   1194 C C   . TYR A 1 161 ? -11.05808 -2.83127  10.36041  1.000 38.59248 ? 161 TYR A C   1 
ATOM   1195 O O   . TYR A 1 161 ? -11.78500 -2.40401  11.26176  1.000 38.35005 ? 161 TYR A O   1 
ATOM   1196 C CB  . TYR A 1 161 ? -11.78633 -5.04667  9.45964   1.000 35.21464 ? 161 TYR A CB  1 
ATOM   1197 C CG  . TYR A 1 161 ? -12.04752 -4.53336  8.06067   1.000 32.82750 ? 161 TYR A CG  1 
ATOM   1198 C CD1 . TYR A 1 161 ? -11.29131 -4.98227  6.99410   1.000 34.80228 ? 161 TYR A CD1 1 
ATOM   1199 C CD2 . TYR A 1 161 ? -13.08388 -3.64203  7.79817   1.000 28.74669 ? 161 TYR A CD2 1 
ATOM   1200 C CE1 . TYR A 1 161 ? -11.52891 -4.55268  5.69657   1.000 36.57149 ? 161 TYR A CE1 1 
ATOM   1201 C CE2 . TYR A 1 161 ? -13.34481 -3.21318  6.48775   1.000 29.67923 ? 161 TYR A CE2 1 
ATOM   1202 C CZ  . TYR A 1 161 ? -12.55632 -3.66882  5.44594   1.000 33.86297 ? 161 TYR A CZ  1 
ATOM   1203 O OH  . TYR A 1 161 ? -12.76924 -3.26214  4.13721   1.000 34.54192 ? 161 TYR A OH  1 
ATOM   1204 N N   . MET A 1 162 ? -10.49401 -2.05472  9.44031   1.000 39.45964 ? 162 MET A N   1 
ATOM   1205 C CA  . MET A 1 162 ? -10.90891 -0.68076  9.19420   1.000 36.28772 ? 162 MET A CA  1 
ATOM   1206 C C   . MET A 1 162 ? -11.14237 -0.51162  7.70008   1.000 33.87291 ? 162 MET A C   1 
ATOM   1207 O O   . MET A 1 162 ? -10.31398 -0.94109  6.88790   1.000 38.47473 ? 162 MET A O   1 
ATOM   1208 C CB  . MET A 1 162 ? -9.86250  0.32126   9.70478   1.000 38.17774 ? 162 MET A CB  1 
ATOM   1209 C CG  . MET A 1 162 ? -10.17890 1.77099   9.35016   1.000 38.72867 ? 162 MET A CG  1 
ATOM   1210 S SD  . MET A 1 162 ? -9.27017  2.99452   10.34815  1.000 44.61026 ? 162 MET A SD  1 
ATOM   1211 C CE  . MET A 1 162 ? -10.20016 3.02432   11.88281  1.000 36.12303 ? 162 MET A CE  1 
ATOM   1212 N N   . HIS A 1 163 ? -12.25281 0.13243   7.32899   1.000 29.70038 ? 163 HIS A N   1 
ATOM   1213 C CA  . HIS A 1 163 ? -12.59331 0.23005   5.91363   1.000 29.27727 ? 163 HIS A CA  1 
ATOM   1214 C C   . HIS A 1 163 ? -11.84299 1.35793   5.20264   1.000 34.85078 ? 163 HIS A C   1 
ATOM   1215 O O   . HIS A 1 163 ? -11.82947 2.48600   5.69409   1.000 32.84669 ? 163 HIS A O   1 
ATOM   1216 C CB  . HIS A 1 163 ? -14.07940 0.48651   5.73852   1.000 29.08786 ? 163 HIS A CB  1 
ATOM   1217 C CG  . HIS A 1 163 ? -14.49582 0.38454   4.31861   1.000 27.56279 ? 163 HIS A CG  1 
ATOM   1218 N ND1 . HIS A 1 163 ? -14.05582 -0.63887  3.50432   1.000 30.76840 ? 163 HIS A ND1 1 
ATOM   1219 C CD2 . HIS A 1 163 ? -15.20088 1.22191   3.53044   1.000 29.93080 ? 163 HIS A CD2 1 
ATOM   1220 C CE1 . HIS A 1 163 ? -14.52171 -0.45241  2.28201   1.000 33.52609 ? 163 HIS A CE1 1 
ATOM   1221 N NE2 . HIS A 1 163 ? -15.20736 0.67744   2.26866   1.000 34.47178 ? 163 HIS A NE2 1 
ATOM   1222 N N   . HIS A 1 164 ? -11.32273 1.07032   3.98883   1.000 33.79358 ? 164 HIS A N   1 
ATOM   1223 C CA  . HIS A 1 164 ? -10.58077 2.06104   3.18859   1.000 37.97413 ? 164 HIS A CA  1 
ATOM   1224 C C   . HIS A 1 164 ? -11.12427 2.26236   1.77621   1.000 39.39372 ? 164 HIS A C   1 
ATOM   1225 O O   . HIS A 1 164 ? -11.05965 3.38450   1.27167   1.000 38.97191 ? 164 HIS A O   1 
ATOM   1226 C CB  . HIS A 1 164 ? -9.08756  1.71033   3.04879   1.000 31.48727 ? 164 HIS A CB  1 
ATOM   1227 C CG  . HIS A 1 164 ? -8.29869  1.93168   4.30002   1.000 38.28796 ? 164 HIS A CG  1 
ATOM   1228 N ND1 . HIS A 1 164 ? -7.35501  2.93415   4.43034   1.000 36.65670 ? 164 HIS A ND1 1 
ATOM   1229 C CD2 . HIS A 1 164 ? -8.31435  1.27253   5.48114   1.000 34.34737 ? 164 HIS A CD2 1 
ATOM   1230 C CE1 . HIS A 1 164 ? -6.83026  2.88130   5.64398   1.000 33.68641 ? 164 HIS A CE1 1 
ATOM   1231 N NE2 . HIS A 1 164 ? -7.39529  1.88340   6.30002   1.000 40.32375 ? 164 HIS A NE2 1 
ATOM   1232 N N   . MET A 1 165 ? -11.67116 1.23121   1.12143   1.000 37.93939 ? 165 MET A N   1 
ATOM   1233 C CA  . MET A 1 165 ? -11.97342 1.41285   -0.29782  1.000 39.68550 ? 165 MET A CA  1 
ATOM   1234 C C   . MET A 1 165 ? -12.79959 0.25860   -0.86178  1.000 41.55465 ? 165 MET A C   1 
ATOM   1235 O O   . MET A 1 165 ? -12.97833 -0.78812  -0.23113  1.000 43.02133 ? 165 MET A O   1 
ATOM   1236 C CB  . MET A 1 165 ? -10.67845 1.55524   -1.09211  1.000 42.30930 ? 165 MET A CB  1 
ATOM   1237 C CG  . MET A 1 165 ? -9.91126  0.25629   -1.18110  1.000 45.10413 ? 165 MET A CG  1 
ATOM   1238 S SD  . MET A 1 165 ? -8.25440  0.51072   -1.87830  1.000 58.49675 ? 165 MET A SD  1 
ATOM   1239 C CE  . MET A 1 165 ? -7.98611  -1.06086  -2.68438  1.000 51.83552 ? 165 MET A CE  1 
ATOM   1240 N N   . GLU A 1 166 ? -13.29515 0.47540   -2.07948  1.000 41.53310 ? 166 GLU A N   1 
ATOM   1241 C CA  . GLU A 1 166 ? -14.08297 -0.48900  -2.82821  1.000 39.89620 ? 166 GLU A CA  1 
ATOM   1242 C C   . GLU A 1 166 ? -13.37631 -0.78870  -4.14100  1.000 48.39814 ? 166 GLU A C   1 
ATOM   1243 O O   . GLU A 1 166 ? -12.89334 0.13169   -4.81691  1.000 41.51663 ? 166 GLU A O   1 
ATOM   1244 C CB  . GLU A 1 166 ? -15.48931 0.05491   -3.09521  1.000 43.20068 ? 166 GLU A CB  1 
ATOM   1245 C CG  . GLU A 1 166 ? -16.33822 -0.77504  -4.06320  1.000 45.82784 ? 166 GLU A CG  1 
ATOM   1246 C CD  . GLU A 1 166 ? -17.80734 -0.32671  -4.10090  1.000 46.59676 ? 166 GLU A CD  1 
ATOM   1247 O OE1 . GLU A 1 166 ? -18.37177 -0.03831  -3.02828  1.000 40.05807 ? 166 GLU A OE1 1 
ATOM   1248 O OE2 . GLU A 1 166 ? -18.38874 -0.24750  -5.20527  1.000 49.83509 ? 166 GLU A OE2 1 
ATOM   1249 N N   . LEU A 1 167 ? -13.32059 -2.06647  -4.49828  1.000 45.54933 ? 167 LEU A N   1 
ATOM   1250 C CA  . LEU A 1 167 ? -12.65441 -2.50116  -5.71503  1.000 46.01296 ? 167 LEU A CA  1 
ATOM   1251 C C   . LEU A 1 167 ? -13.64570 -2.54741  -6.86158  1.000 49.33770 ? 167 LEU A C   1 
ATOM   1252 O O   . LEU A 1 167 ? -14.86585 -2.50181  -6.66144  1.000 53.46684 ? 167 LEU A O   1 
ATOM   1253 C CB  . LEU A 1 167 ? -11.99984 -3.85926  -5.49051  1.000 46.40067 ? 167 LEU A CB  1 
ATOM   1254 C CG  . LEU A 1 167 ? -10.87104 -3.83846  -4.46064  1.000 43.50388 ? 167 LEU A CG  1 
ATOM   1255 C CD1 . LEU A 1 167 ? -10.42167 -5.25577  -4.09542  1.000 45.54616 ? 167 LEU A CD1 1 
ATOM   1256 C CD2 . LEU A 1 167 ? -9.72186  -3.02739  -4.99266  1.000 51.15509 ? 167 LEU A CD2 1 
ATOM   1257 N N   . PRO A 1 168 ? -13.14713 -2.63703  -8.09559  1.000 51.66954 ? 168 PRO A N   1 
ATOM   1258 C CA  . PRO A 1 168 ? -14.04749 -2.53942  -9.25224  1.000 49.68112 ? 168 PRO A CA  1 
ATOM   1259 C C   . PRO A 1 168 ? -15.13756 -3.59486  -9.27358  1.000 51.35973 ? 168 PRO A C   1 
ATOM   1260 O O   . PRO A 1 168 ? -16.23950 -3.31192  -9.75899  1.000 52.70912 ? 168 PRO A O   1 
ATOM   1261 C CB  . PRO A 1 168 ? -13.08976 -2.68156  -10.44090 1.000 52.99823 ? 168 PRO A CB  1 
ATOM   1262 C CG  . PRO A 1 168 ? -11.77474 -2.19973  -9.91672  1.000 51.47835 ? 168 PRO A CG  1 
ATOM   1263 C CD  . PRO A 1 168 ? -11.72689 -2.64102  -8.49205  1.000 51.17281 ? 168 PRO A CD  1 
ATOM   1264 N N   . THR A 1 169 ? -14.86720 -4.80733  -8.77899  1.000 50.48808 ? 169 THR A N   1 
ATOM   1265 C CA  . THR A 1 169 ? -15.89047 -5.84072  -8.74518  1.000 50.83024 ? 169 THR A CA  1 
ATOM   1266 C C   . THR A 1 169 ? -16.97986 -5.57577  -7.70258  1.000 55.04268 ? 169 THR A C   1 
ATOM   1267 O O   . THR A 1 169 ? -17.92958 -6.36699  -7.62332  1.000 57.26856 ? 169 THR A O   1 
ATOM   1268 C CB  . THR A 1 169 ? -15.25621 -7.21346  -8.47737  1.000 52.84505 ? 169 THR A CB  1 
ATOM   1269 O OG1 . THR A 1 169 ? -14.57640 -7.19966  -7.20950  1.000 54.32080 ? 169 THR A OG1 1 
ATOM   1270 C CG2 . THR A 1 169 ? -14.27264 -7.57276  -9.57921  1.000 55.51566 ? 169 THR A CG2 1 
ATOM   1271 N N   . GLY A 1 170 ? -16.87264 -4.52088  -6.89531  1.000 47.36255 ? 170 GLY A N   1 
ATOM   1272 C CA  . GLY A 1 170 ? -17.87905 -4.24121  -5.88413  1.000 46.58305 ? 170 GLY A CA  1 
ATOM   1273 C C   . GLY A 1 170 ? -17.65375 -4.89806  -4.53865  1.000 48.75953 ? 170 GLY A C   1 
ATOM   1274 O O   . GLY A 1 170 ? -18.60149 -5.00574  -3.74911  1.000 52.02284 ? 170 GLY A O   1 
ATOM   1275 N N   . VAL A 1 171 ? -16.43937 -5.37061  -4.26157  1.000 43.74805 ? 171 VAL A N   1 
ATOM   1276 C CA  . VAL A 1 171 ? -16.08264 -5.85864  -2.93585  1.000 41.03360 ? 171 VAL A CA  1 
ATOM   1277 C C   . VAL A 1 171 ? -15.15983 -4.84468  -2.27611  1.000 41.51536 ? 171 VAL A C   1 
ATOM   1278 O O   . VAL A 1 171 ? -14.74796 -3.85153  -2.89752  1.000 41.87336 ? 171 VAL A O   1 
ATOM   1279 C CB  . VAL A 1 171 ? -15.43282 -7.25680  -2.98929  1.000 44.84410 ? 171 VAL A CB  1 
ATOM   1280 C CG1 . VAL A 1 171 ? -16.44035 -8.29820  -3.50283  1.000 43.81193 ? 171 VAL A CG1 1 
ATOM   1281 C CG2 . VAL A 1 171 ? -14.16657 -7.25060  -3.84921  1.000 37.56006 ? 171 VAL A CG2 1 
ATOM   1282 N N   . HIS A 1 172 ? -14.82852 -5.08747  -1.01292  1.000 39.54398 ? 172 HIS A N   1 
ATOM   1283 C CA  . HIS A 1 172 ? -14.25196 -4.06159  -0.16669  1.000 40.80160 ? 172 HIS A CA  1 
ATOM   1284 C C   . HIS A 1 172 ? -12.90711 -4.49058  0.39548   1.000 39.54170 ? 172 HIS A C   1 
ATOM   1285 O O   . HIS A 1 172 ? -12.61618 -5.68290  0.55554   1.000 35.70789 ? 172 HIS A O   1 
ATOM   1286 C CB  . HIS A 1 172 ? -15.24830 -3.69466  0.93413   1.000 39.42314 ? 172 HIS A CB  1 
ATOM   1287 C CG  . HIS A 1 172 ? -16.52167 -3.15050  0.37593   1.000 39.70102 ? 172 HIS A CG  1 
ATOM   1288 N ND1 . HIS A 1 172 ? -17.67228 -3.90227  0.27560   1.000 36.96650 ? 172 HIS A ND1 1 
ATOM   1289 C CD2 . HIS A 1 172 ? -16.80342 -1.94974  -0.18629  1.000 39.09903 ? 172 HIS A CD2 1 
ATOM   1290 C CE1 . HIS A 1 172 ? -18.62278 -3.17107  -0.28169  1.000 40.06717 ? 172 HIS A CE1 1 
ATOM   1291 N NE2 . HIS A 1 172 ? -18.11665 -1.98646  -0.58440  1.000 41.29132 ? 172 HIS A NE2 1 
ATOM   1292 N N   . ALA A 1 173 ? -12.07314 -3.49068  0.64164   1.000 37.94361 ? 173 ALA A N   1 
ATOM   1293 C CA  . ALA A 1 173 ? -10.69189 -3.71841  1.02835   1.000 38.40662 ? 173 ALA A CA  1 
ATOM   1294 C C   . ALA A 1 173 ? -10.35729 -2.78044  2.16790   1.000 35.50388 ? 173 ALA A C   1 
ATOM   1295 O O   . ALA A 1 173 ? -10.88432 -1.66991  2.25776   1.000 37.04811 ? 173 ALA A O   1 
ATOM   1296 C CB  . ALA A 1 173 ? -9.72125  -3.49626  -0.14181  1.000 39.07948 ? 173 ALA A CB  1 
ATOM   1297 N N   . GLY A 1 174 ? -9.48151  -3.23627  3.03886   1.000 31.97029 ? 174 GLY A N   1 
ATOM   1298 C CA  . GLY A 1 174 ? -9.15773  -2.43971  4.19194   1.000 30.99101 ? 174 GLY A CA  1 
ATOM   1299 C C   . GLY A 1 174 ? -7.95920  -3.01351  4.89376   1.000 32.55949 ? 174 GLY A C   1 
ATOM   1300 O O   . GLY A 1 174 ? -7.27268  -3.89184  4.37352   1.000 38.35193 ? 174 GLY A O   1 
ATOM   1301 N N   . THR A 1 175 ? -7.74290  -2.52393  6.10472   1.000 35.14076 ? 175 THR A N   1 
ATOM   1302 C CA  . THR A 1 175 ? -6.55423  -2.80933  6.87885   1.000 37.18741 ? 175 THR A CA  1 
ATOM   1303 C C   . THR A 1 175 ? -6.95445  -3.29748  8.25658   1.000 35.33182 ? 175 THR A C   1 
ATOM   1304 O O   . THR A 1 175 ? -8.09905  -3.15451  8.69586   1.000 37.59277 ? 175 THR A O   1 
ATOM   1305 C CB  . THR A 1 175 ? -5.67976  -1.55312  7.04836   1.000 38.36436 ? 175 THR A CB  1 
ATOM   1306 O OG1 . THR A 1 175 ? -6.35853  -0.64466  7.93270   1.000 37.36409 ? 175 THR A OG1 1 
ATOM   1307 C CG2 . THR A 1 175 ? -5.45714  -0.90441  5.71955   1.000 36.56244 ? 175 THR A CG2 1 
ATOM   1308 N N   . ASP A 1 176 ? -5.96779  -3.83815  8.94989   1.000 39.00898 ? 176 ASP A N   1 
ATOM   1309 C CA  . ASP A 1 176 ? -6.09114  -4.02223  10.37590  1.000 38.96109 ? 176 ASP A CA  1 
ATOM   1310 C C   . ASP A 1 176 ? -5.88932  -2.67475  11.06356  1.000 40.65134 ? 176 ASP A C   1 
ATOM   1311 O O   . ASP A 1 176 ? -5.64656  -1.64315  10.42561  1.000 41.64831 ? 176 ASP A O   1 
ATOM   1312 C CB  . ASP A 1 176 ? -5.10602  -5.08500  10.85590  1.000 38.22957 ? 176 ASP A CB  1 
ATOM   1313 C CG  . ASP A 1 176 ? -3.65874  -4.76276  10.49704  1.000 41.39205 ? 176 ASP A CG  1 
ATOM   1314 O OD1 . ASP A 1 176 ? -3.29255  -3.56964  10.37703  1.000 43.65901 ? 176 ASP A OD1 1 
ATOM   1315 O OD2 . ASP A 1 176 ? -2.87944  -5.71523  10.33024  1.000 39.81167 ? 176 ASP A OD2 1 
ATOM   1316 N N   . LEU A 1 177 ? -5.99979  -2.67453  12.37911  1.000 39.68458 ? 177 LEU A N   1 
ATOM   1317 C CA  . LEU A 1 177 ? -5.90003  -1.41767  13.08749  1.000 45.39348 ? 177 LEU A CA  1 
ATOM   1318 C C   . LEU A 1 177 ? -4.46653  -0.94494  13.21951  1.000 44.49225 ? 177 LEU A C   1 
ATOM   1319 O O   . LEU A 1 177 ? -4.25537  0.15300   13.72315  1.000 45.97561 ? 177 LEU A O   1 
ATOM   1320 C CB  . LEU A 1 177 ? -6.54947  -1.51919  14.46534  1.000 31.70751 ? 177 LEU A CB  1 
ATOM   1321 C CG  . LEU A 1 177 ? -8.03878  -1.15643  14.56215  1.000 46.85193 ? 177 LEU A CG  1 
ATOM   1322 C CD1 . LEU A 1 177 ? -8.28224  0.32161   14.32941  1.000 41.62815 ? 177 LEU A CD1 1 
ATOM   1323 C CD2 . LEU A 1 177 ? -8.91108  -2.00998  13.59953  1.000 44.06899 ? 177 LEU A CD2 1 
ATOM   1324 N N   . GLU A 1 178 ? -3.48677  -1.75148  12.80681  1.000 49.74263 ? 178 GLU A N   1 
ATOM   1325 C CA  . GLU A 1 178 ? -2.13507  -1.24167  12.62302  1.000 45.73117 ? 178 GLU A CA  1 
ATOM   1326 C C   . GLU A 1 178 ? -1.96865  -0.53995  11.29431  1.000 44.73047 ? 178 GLU A C   1 
ATOM   1327 O O   . GLU A 1 178 ? -0.87541  -0.04539  11.01443  1.000 49.77951 ? 178 GLU A O   1 
ATOM   1328 C CB  . GLU A 1 178 ? -1.09718  -2.36196  12.69686  1.000 45.84777 ? 178 GLU A CB  1 
ATOM   1329 C CG  . GLU A 1 178 ? -0.82802  -2.94767  14.06463  1.000 51.15862 ? 178 GLU A CG  1 
ATOM   1330 C CD  . GLU A 1 178 ? 0.11686   -4.14794  13.96961  1.000 58.58277 ? 178 GLU A CD  1 
ATOM   1331 O OE1 . GLU A 1 178 ? 0.88414   -4.23850  12.97941  1.000 61.83612 ? 178 GLU A OE1 1 
ATOM   1332 O OE2 . GLU A 1 178 ? 0.09232   -5.00052  14.87866  1.000 60.00891 ? 178 GLU A OE2 1 
ATOM   1333 N N   . GLY A 1 179 ? -2.99326  -0.52260  10.45494  1.000 40.14606 ? 179 GLY A N   1 
ATOM   1334 C CA  . GLY A 1 179 ? -2.89888  0.14671   9.17496   1.000 40.87568 ? 179 GLY A CA  1 
ATOM   1335 C C   . GLY A 1 179 ? -2.33568  -0.68279  8.04942   1.000 44.89562 ? 179 GLY A C   1 
ATOM   1336 O O   . GLY A 1 179 ? -2.09586  -0.13450  6.96801   1.000 38.57037 ? 179 GLY A O   1 
ATOM   1337 N N   . ASN A 1 180 ? -2.13205  -1.98879  8.24871   1.000 43.72949 ? 180 ASN A N   1 
ATOM   1338 C CA  . ASN A 1 180 ? -1.57673  -2.84211  7.20046   1.000 41.00138 ? 180 ASN A CA  1 
ATOM   1339 C C   . ASN A 1 180 ? -2.71816  -3.49192  6.42714   1.000 39.97150 ? 180 ASN A C   1 
ATOM   1340 O O   . ASN A 1 180 ? -3.55610  -4.19860  7.01127   1.000 40.31939 ? 180 ASN A O   1 
ATOM   1341 C CB  . ASN A 1 180 ? -0.63224  -3.90014  7.78663   1.000 41.61661 ? 180 ASN A CB  1 
ATOM   1342 C CG  . ASN A 1 180 ? 0.69475   -3.30811  8.28169   1.000 50.06170 ? 180 ASN A CG  1 
ATOM   1343 O OD1 . ASN A 1 180 ? 1.30889   -2.45098  7.61444   1.000 48.32642 ? 180 ASN A OD1 1 
ATOM   1344 N ND2 . ASN A 1 180 ? 1.13322   -3.74669  9.46592   1.000 42.27883 ? 180 ASN A ND2 1 
ATOM   1345 N N   . PHE A 1 181 ? -2.75634  -3.26033  5.11954   1.000 37.54023 ? 181 PHE A N   1 
ATOM   1346 C CA  . PHE A 1 181 ? -3.86262  -3.77730  4.32776   1.000 38.44221 ? 181 PHE A CA  1 
ATOM   1347 C C   . PHE A 1 181 ? -3.98189  -5.29413  4.46366   1.000 38.13813 ? 181 PHE A C   1 
ATOM   1348 O O   . PHE A 1 181 ? -2.99014  -6.00898  4.65216   1.000 36.92864 ? 181 PHE A O   1 
ATOM   1349 C CB  . PHE A 1 181 ? -3.69149  -3.41887  2.85634   1.000 36.59631 ? 181 PHE A CB  1 
ATOM   1350 C CG  . PHE A 1 181 ? -4.45171  -2.18855  2.43905   1.000 42.97673 ? 181 PHE A CG  1 
ATOM   1351 C CD1 . PHE A 1 181 ? -5.82161  -2.25351  2.20172   1.000 38.91561 ? 181 PHE A CD1 1 
ATOM   1352 C CD2 . PHE A 1 181 ? -3.79283  -0.95840  2.28052   1.000 36.34781 ? 181 PHE A CD2 1 
ATOM   1353 C CE1 . PHE A 1 181 ? -6.53271  -1.13109  1.81438   1.000 41.73570 ? 181 PHE A CE1 1 
ATOM   1354 C CE2 . PHE A 1 181 ? -4.49738  0.16653   1.89436   1.000 38.29869 ? 181 PHE A CE2 1 
ATOM   1355 C CZ  . PHE A 1 181 ? -5.87574  0.08994   1.65979   1.000 34.66465 ? 181 PHE A CZ  1 
ATOM   1356 N N   . TYR A 1 182 ? -5.21871  -5.78206  4.36915   1.000 35.31695 ? 182 TYR A N   1 
ATOM   1357 C CA  . TYR A 1 182 ? -5.46917  -7.18331  4.05741   1.000 33.05622 ? 182 TYR A CA  1 
ATOM   1358 C C   . TYR A 1 182 ? -5.45087  -7.31950  2.54075   1.000 31.55000 ? 182 TYR A C   1 
ATOM   1359 O O   . TYR A 1 182 ? -6.21506  -6.64512  1.84392   1.000 39.63939 ? 182 TYR A O   1 
ATOM   1360 C CB  . TYR A 1 182 ? -6.81522  -7.65680  4.61629   1.000 33.86527 ? 182 TYR A CB  1 
ATOM   1361 C CG  . TYR A 1 182 ? -6.92800  -7.70509  6.12597   1.000 34.46246 ? 182 TYR A CG  1 
ATOM   1362 C CD1 . TYR A 1 182 ? -6.38328  -8.76343  6.85212   1.000 34.49867 ? 182 TYR A CD1 1 
ATOM   1363 C CD2 . TYR A 1 182 ? -7.62433  -6.72849  6.82204   1.000 33.69046 ? 182 TYR A CD2 1 
ATOM   1364 C CE1 . TYR A 1 182 ? -6.50024  -8.82676  8.24704   1.000 36.02524 ? 182 TYR A CE1 1 
ATOM   1365 C CE2 . TYR A 1 182 ? -7.74505  -6.77799  8.20441   1.000 35.18708 ? 182 TYR A CE2 1 
ATOM   1366 C CZ  . TYR A 1 182 ? -7.18271  -7.84118  8.91050   1.000 37.06349 ? 182 TYR A CZ  1 
ATOM   1367 O OH  . TYR A 1 182 ? -7.29937  -7.90679  10.28128  1.000 37.57898 ? 182 TYR A OH  1 
ATOM   1368 N N   . GLY A 1 183 ? -4.57962  -8.16441  2.02442   1.000 32.11747 ? 183 GLY A N   1 
ATOM   1369 C CA  . GLY A 1 183 ? -4.46865  -8.34107  0.59395   1.000 37.75850 ? 183 GLY A CA  1 
ATOM   1370 C C   . GLY A 1 183 ? -3.50287  -7.34706  -0.03459  1.000 40.92374 ? 183 GLY A C   1 
ATOM   1371 O O   . GLY A 1 183 ? -2.98973  -6.44405  0.63227   1.000 40.83070 ? 183 GLY A O   1 
ATOM   1372 N N   . PRO A 1 184 ? -3.25501  -7.49874  -1.34965  1.000 38.37115 ? 184 PRO A N   1 
ATOM   1373 C CA  . PRO A 1 184 ? -2.22743  -6.70525  -2.05028  1.000 43.28104 ? 184 PRO A CA  1 
ATOM   1374 C C   . PRO A 1 184 ? -2.76271  -5.38749  -2.60032  1.000 41.86065 ? 184 PRO A C   1 
ATOM   1375 O O   . PRO A 1 184 ? -2.63665  -5.09171  -3.79743  1.000 43.78525 ? 184 PRO A O   1 
ATOM   1376 C CB  . PRO A 1 184 ? -1.80545  -7.64133  -3.18472  1.000 42.48081 ? 184 PRO A CB  1 
ATOM   1377 C CG  . PRO A 1 184 ? -3.10495  -8.36418  -3.51938  1.000 45.79024 ? 184 PRO A CG  1 
ATOM   1378 C CD  . PRO A 1 184 ? -3.84843  -8.52667  -2.21966  1.000 38.02728 ? 184 PRO A CD  1 
ATOM   1379 N N   . PHE A 1 185 ? -3.39181  -4.59415  -1.74258  1.000 36.34057 ? 185 PHE A N   1 
ATOM   1380 C CA  . PHE A 1 185 ? -4.05499  -3.38521  -2.18646  1.000 40.42898 ? 185 PHE A CA  1 
ATOM   1381 C C   . PHE A 1 185 ? -3.37215  -2.15975  -1.57401  1.000 42.76009 ? 185 PHE A C   1 
ATOM   1382 O O   . PHE A 1 185 ? -2.63162  -2.25073  -0.58556  1.000 37.95148 ? 185 PHE A O   1 
ATOM   1383 C CB  . PHE A 1 185 ? -5.55527  -3.44947  -1.83586  1.000 43.07297 ? 185 PHE A CB  1 
ATOM   1384 C CG  . PHE A 1 185 ? -6.20623  -4.76561  -2.21749  1.000 42.03459 ? 185 PHE A CG  1 
ATOM   1385 C CD1 . PHE A 1 185 ? -6.36382  -5.12000  -3.55095  1.000 42.59802 ? 185 PHE A CD1 1 
ATOM   1386 C CD2 . PHE A 1 185 ? -6.66076  -5.64004  -1.24333  1.000 42.58125 ? 185 PHE A CD2 1 
ATOM   1387 C CE1 . PHE A 1 185 ? -6.95663  -6.34130  -3.90719  1.000 45.36555 ? 185 PHE A CE1 1 
ATOM   1388 C CE2 . PHE A 1 185 ? -7.25198  -6.85398  -1.59394  1.000 40.58715 ? 185 PHE A CE2 1 
ATOM   1389 C CZ  . PHE A 1 185 ? -7.39806  -7.19566  -2.92672  1.000 40.86012 ? 185 PHE A CZ  1 
ATOM   1390 N N   . VAL A 1 186 ? -3.61920  -0.99913  -2.17045  1.000 41.66820 ? 186 VAL A N   1 
ATOM   1391 C CA  . VAL A 1 186 ? -3.01687  0.23814   -1.68547  1.000 39.40767 ? 186 VAL A CA  1 
ATOM   1392 C C   . VAL A 1 186 ? -4.08368  1.32383   -1.60233  1.000 40.22526 ? 186 VAL A C   1 
ATOM   1393 O O   . VAL A 1 186 ? -5.05856  1.32194   -2.35923  1.000 40.87636 ? 186 VAL A O   1 
ATOM   1394 C CB  . VAL A 1 186 ? -1.85070  0.67681   -2.59593  1.000 39.61885 ? 186 VAL A CB  1 
ATOM   1395 C CG1 . VAL A 1 186 ? -0.70162  -0.30176  -2.47099  1.000 36.99927 ? 186 VAL A CG1 1 
ATOM   1396 C CG2 . VAL A 1 186 ? -2.32434  0.75564   -4.02498  1.000 38.62084 ? 186 VAL A CG2 1 
ATOM   1397 N N   . ASP A 1 187 ? -3.90251  2.25899   -0.67074  1.000 40.59254 ? 187 ASP A N   1 
ATOM   1398 C CA  . ASP A 1 187 ? -4.89259  3.32020   -0.48148  1.000 43.08093 ? 187 ASP A CA  1 
ATOM   1399 C C   . ASP A 1 187 ? -4.59859  4.48408   -1.43386  1.000 46.25632 ? 187 ASP A C   1 
ATOM   1400 O O   . ASP A 1 187 ? -4.18608  5.57173   -1.04151  1.000 46.00671 ? 187 ASP A O   1 
ATOM   1401 C CB  . ASP A 1 187 ? -4.94257  3.76408   0.98073   1.000 46.29300 ? 187 ASP A CB  1 
ATOM   1402 C CG  . ASP A 1 187 ? -3.57887  4.16103   1.53517   1.000 42.39025 ? 187 ASP A CG  1 
ATOM   1403 O OD1 . ASP A 1 187 ? -2.56687  3.78288   0.91989   1.000 41.59261 ? 187 ASP A OD1 1 
ATOM   1404 O OD2 . ASP A 1 187 ? -3.52826  4.81628   2.60476   1.000 39.69261 ? 187 ASP A OD2 1 
ATOM   1405 N N   . ARG A 1 188 ? -4.85243  4.23366   -2.71882  1.000 49.10467 ? 188 ARG A N   1 
ATOM   1406 C CA  . ARG A 1 188 ? -4.80590  5.27088   -3.74123  1.000 51.06505 ? 188 ARG A CA  1 
ATOM   1407 C C   . ARG A 1 188 ? -5.78753  4.92345   -4.85699  1.000 57.67555 ? 188 ARG A C   1 
ATOM   1408 O O   . ARG A 1 188 ? -6.09091  3.74785   -5.09516  1.000 47.88981 ? 188 ARG A O   1 
ATOM   1409 C CB  . ARG A 1 188 ? -3.38932  5.43694   -4.29956  1.000 52.26903 ? 188 ARG A CB  1 
ATOM   1410 C CG  . ARG A 1 188 ? -2.90518  4.23353   -5.05318  1.000 51.38553 ? 188 ARG A CG  1 
ATOM   1411 C CD  . ARG A 1 188 ? -1.42295  4.05039   -4.85697  1.000 53.12931 ? 188 ARG A CD  1 
ATOM   1412 N NE  . ARG A 1 188 ? -0.67749  5.21377   -5.31477  1.000 49.03668 ? 188 ARG A NE  1 
ATOM   1413 C CZ  . ARG A 1 188 ? 0.64394   5.29919   -5.31049  1.000 56.90235 ? 188 ARG A CZ  1 
ATOM   1414 N NH1 . ARG A 1 188 ? 1.39775   4.32247   -4.83447  1.000 50.47110 ? 188 ARG A NH1 1 
ATOM   1415 N NH2 . ARG A 1 188 ? 1.22463   6.39211   -5.79761  1.000 61.52957 ? 188 ARG A NH2 1 
ATOM   1416 N N   . GLN A 1 189 ? -6.27651  5.95666   -5.55147  1.000 56.98780 ? 189 GLN A N   1 
ATOM   1417 C CA  . GLN A 1 189 ? -7.33458  5.78217   -6.55144  1.000 59.01314 ? 189 GLN A CA  1 
ATOM   1418 C C   . GLN A 1 189 ? -6.77522  5.30811   -7.89462  1.000 62.68200 ? 189 GLN A C   1 
ATOM   1419 O O   . GLN A 1 189 ? -6.95402  5.93972   -8.93578  1.000 67.81349 ? 189 GLN A O   1 
ATOM   1420 C CB  . GLN A 1 189 ? -8.11810  7.07415   -6.73365  1.000 59.97168 ? 189 GLN A CB  1 
ATOM   1421 C CG  . GLN A 1 189 ? -8.79219  7.57434   -5.47982  1.000 64.67045 ? 189 GLN A CG  1 
ATOM   1422 C CD  . GLN A 1 189 ? -10.29393 7.37950   -5.49781  1.000 61.32109 ? 189 GLN A CD  1 
ATOM   1423 O OE1 . GLN A 1 189 ? -10.80836 6.46760   -6.13876  1.000 59.64658 ? 189 GLN A OE1 1 
ATOM   1424 N NE2 . GLN A 1 189 ? -11.00613 8.24745   -4.79394  1.000 67.48046 ? 189 GLN A NE2 1 
ATOM   1425 N N   . ILE A 1 190 ? -6.09878  4.16519   -7.86409  1.000 61.12811 ? 190 ILE A N   1 
ATOM   1426 C CA  . ILE A 1 190 ? -5.55911  3.56023   -9.07143  1.000 61.52360 ? 190 ILE A CA  1 
ATOM   1427 C C   . ILE A 1 190 ? -6.31493  2.27063   -9.36065  1.000 62.93808 ? 190 ILE A C   1 
ATOM   1428 O O   . ILE A 1 190 ? -7.09951  1.77767   -8.54621  1.000 52.91021 ? 190 ILE A O   1 
ATOM   1429 C CB  . ILE A 1 190 ? -4.04571  3.28929   -8.97728  1.000 60.72483 ? 190 ILE A CB  1 
ATOM   1430 C CG1 . ILE A 1 190 ? -3.75225  2.28301   -7.86391  1.000 57.22822 ? 190 ILE A CG1 1 
ATOM   1431 C CG2 . ILE A 1 190 ? -3.26318  4.59469   -8.79383  1.000 63.20534 ? 190 ILE A CG2 1 
ATOM   1432 C CD1 . ILE A 1 190 ? -2.36064  1.69209   -7.96321  1.000 58.19286 ? 190 ILE A CD1 1 
ATOM   1433 N N   . ALA A 1 191 ? -6.06164  1.72794   -10.54819 1.000 63.26055 ? 191 ALA A N   1 
ATOM   1434 C CA  . ALA A 1 191 ? -6.65196  0.46603   -10.96720 1.000 68.20961 ? 191 ALA A CA  1 
ATOM   1435 C C   . ALA A 1 191 ? -6.02102  -0.68000  -10.18647 1.000 62.57639 ? 191 ALA A C   1 
ATOM   1436 O O   . ALA A 1 191 ? -4.79991  -0.87579  -10.23284 1.000 63.64925 ? 191 ALA A O   1 
ATOM   1437 C CB  . ALA A 1 191 ? -6.44919  0.27084   -12.46958 1.000 67.47607 ? 191 ALA A CB  1 
ATOM   1438 N N   . GLN A 1 192 ? -6.84601  -1.41925  -9.45145  1.000 57.67070 ? 192 GLN A N   1 
ATOM   1439 C CA  . GLN A 1 192 ? -6.40343  -2.63364  -8.78363  1.000 52.14357 ? 192 GLN A CA  1 
ATOM   1440 C C   . GLN A 1 192 ? -7.59451  -3.56848  -8.70309  1.000 58.64628 ? 192 GLN A C   1 
ATOM   1441 O O   . GLN A 1 192 ? -8.74735  -3.14487  -8.82037  1.000 60.30200 ? 192 GLN A O   1 
ATOM   1442 C CB  . GLN A 1 192 ? -5.81560  -2.35928  -7.38990  1.000 48.20109 ? 192 GLN A CB  1 
ATOM   1443 C CG  . GLN A 1 192 ? -6.17695  -1.00757  -6.82853  1.000 47.97730 ? 192 GLN A CG  1 
ATOM   1444 C CD  . GLN A 1 192 ? -5.57433  -0.74810  -5.46163  1.000 45.59138 ? 192 GLN A CD  1 
ATOM   1445 O OE1 . GLN A 1 192 ? -4.86990  -1.58958  -4.90229  1.000 43.58761 ? 192 GLN A OE1 1 
ATOM   1446 N NE2 . GLN A 1 192 ? -5.84697  0.43364   -4.91613  1.000 44.44061 ? 192 GLN A NE2 1 
ATOM   1447 N N   . ALA A 1 193 ? -7.30442  -4.85148  -8.51150  1.000 52.36814 ? 193 ALA A N   1 
ATOM   1448 C CA  . ALA A 1 193 ? -8.32043  -5.87780  -8.66363  1.000 51.11579 ? 193 ALA A CA  1 
ATOM   1449 C C   . ALA A 1 193 ? -8.06731  -6.99439  -7.66717  1.000 52.50140 ? 193 ALA A C   1 
ATOM   1450 O O   . ALA A 1 193 ? -6.91716  -7.32119  -7.35072  1.000 47.50266 ? 193 ALA A O   1 
ATOM   1451 C CB  . ALA A 1 193 ? -8.34472  -6.44759  -10.08686 1.000 45.96189 ? 193 ALA A CB  1 
ATOM   1452 N N   . ALA A 1 194 ? -9.15683  -7.55941  -7.16487  1.000 48.05682 ? 194 ALA A N   1 
ATOM   1453 C CA  . ALA A 1 194 ? -9.05756  -8.68094  -6.24666  1.000 49.65144 ? 194 ALA A CA  1 
ATOM   1454 C C   . ALA A 1 194 ? -8.56162  -9.91744  -6.98258  1.000 49.24821 ? 194 ALA A C   1 
ATOM   1455 O O   . ALA A 1 194 ? -8.93391  -10.15744 -8.13526  1.000 48.79508 ? 194 ALA A O   1 
ATOM   1456 C CB  . ALA A 1 194 ? -10.42420 -8.95786  -5.61856  1.000 54.02786 ? 194 ALA A CB  1 
ATOM   1457 N N   . GLY A 1 195 ? -7.71737  -10.70177 -6.31677  1.000 41.84771 ? 195 GLY A N   1 
ATOM   1458 C CA  . GLY A 1 195 ? -7.37110  -12.01195 -6.83216  1.000 52.59737 ? 195 GLY A CA  1 
ATOM   1459 C C   . GLY A 1 195 ? -8.59670  -12.91138 -6.93383  1.000 49.71843 ? 195 GLY A C   1 
ATOM   1460 O O   . GLY A 1 195 ? -9.70255  -12.56915 -6.51770  1.000 47.97338 ? 195 GLY A O   1 
ATOM   1461 N N   . THR A 1 196 ? -8.38764  -14.09473 -7.50580  1.000 54.58985 ? 196 THR A N   1 
ATOM   1462 C CA  . THR A 1 196 ? -9.48387  -15.04588 -7.67367  1.000 56.58519 ? 196 THR A CA  1 
ATOM   1463 C C   . THR A 1 196 ? -9.91206  -15.60748 -6.32491  1.000 53.76296 ? 196 THR A C   1 
ATOM   1464 O O   . THR A 1 196 ? -9.07613  -15.99716 -5.49909  1.000 51.19141 ? 196 THR A O   1 
ATOM   1465 C CB  . THR A 1 196 ? -9.08097  -16.19264 -8.60375  1.000 58.97929 ? 196 THR A CB  1 
ATOM   1466 O OG1 . THR A 1 196 ? -8.70077  -15.67065 -9.88289  1.000 63.40254 ? 196 THR A OG1 1 
ATOM   1467 C CG2 . THR A 1 196 ? -10.24542 -17.15064 -8.79163  1.000 59.07470 ? 196 THR A CG2 1 
ATOM   1468 N N   . ASP A 1 197 ? -11.21622 -15.66814 -6.10410  1.000 52.17026 ? 197 ASP A N   1 
ATOM   1469 C CA  . ASP A 1 197 ? -11.67556 -16.13969 -4.81436  1.000 48.44317 ? 197 ASP A CA  1 
ATOM   1470 C C   . ASP A 1 197 ? -11.98297 -17.63582 -4.85478  1.000 53.74396 ? 197 ASP A C   1 
ATOM   1471 O O   . ASP A 1 197 ? -12.01556 -18.27042 -5.91334  1.000 52.05655 ? 197 ASP A O   1 
ATOM   1472 C CB  . ASP A 1 197 ? -12.90006 -15.36061 -4.35879  1.000 46.19097 ? 197 ASP A CB  1 
ATOM   1473 C CG  . ASP A 1 197 ? -13.02074 -15.32856 -2.85956  1.000 45.73671 ? 197 ASP A CG  1 
ATOM   1474 O OD1 . ASP A 1 197 ? -11.99532 -15.58563 -2.18501  1.000 45.59992 ? 197 ASP A OD1 1 
ATOM   1475 O OD2 . ASP A 1 197 ? -14.13234 -15.06290 -2.35270  1.000 47.39233 ? 197 ASP A OD2 1 
ATOM   1476 N N   . THR A 1 198 ? -12.20879 -18.19082 -3.66354  1.000 51.60219 ? 198 THR A N   1 
ATOM   1477 C CA  . THR A 1 198 ? -12.53757 -19.59450 -3.47173  1.000 49.74634 ? 198 THR A CA  1 
ATOM   1478 C C   . THR A 1 198 ? -13.52089 -19.70067 -2.31575  1.000 48.85717 ? 198 THR A C   1 
ATOM   1479 O O   . THR A 1 198 ? -13.73387 -18.74381 -1.56260  1.000 48.27159 ? 198 THR A O   1 
ATOM   1480 C CB  . THR A 1 198 ? -11.28515 -20.43100 -3.19825  1.000 52.13107 ? 198 THR A CB  1 
ATOM   1481 O OG1 . THR A 1 198 ? -10.62446 -19.92534 -2.03017  1.000 50.97393 ? 198 THR A OG1 1 
ATOM   1482 C CG2 . THR A 1 198 ? -10.32977 -20.34319 -4.38229  1.000 54.50940 ? 198 THR A CG2 1 
ATOM   1483 N N   . THR A 1 199 ? -14.12661 -20.87715 -2.18306  1.000 44.49884 ? 199 THR A N   1 
ATOM   1484 C CA  . THR A 1 199 ? -15.11202 -21.12522 -1.14365  1.000 41.18726 ? 199 THR A CA  1 
ATOM   1485 C C   . THR A 1 199 ? -14.42309 -21.67573 0.09771   1.000 39.49696 ? 199 THR A C   1 
ATOM   1486 O O   . THR A 1 199 ? -13.51616 -22.50645 -0.00464  1.000 41.52398 ? 199 THR A O   1 
ATOM   1487 C CB  . THR A 1 199 ? -16.17238 -22.09908 -1.65503  1.000 44.14203 ? 199 THR A CB  1 
ATOM   1488 O OG1 . THR A 1 199 ? -16.83950 -21.52990 -2.79181  1.000 40.35923 ? 199 THR A OG1 1 
ATOM   1489 C CG2 . THR A 1 199 ? -17.17856 -22.41604 -0.56858  1.000 41.30252 ? 199 THR A CG2 1 
ATOM   1490 N N   . ILE A 1 200 ? -14.85553 -21.20662 1.27266   1.000 35.47167 ? 200 ILE A N   1 
ATOM   1491 C CA  . ILE A 1 200 ? -14.25947 -21.63524 2.53787   1.000 32.38731 ? 200 ILE A CA  1 
ATOM   1492 C C   . ILE A 1 200 ? -14.87814 -22.96945 2.96761   1.000 40.12552 ? 200 ILE A C   1 
ATOM   1493 O O   . ILE A 1 200 ? -15.89480 -23.01136 3.68104   1.000 35.76082 ? 200 ILE A O   1 
ATOM   1494 C CB  . ILE A 1 200 ? -14.42749 -20.55586 3.61914   1.000 35.00600 ? 200 ILE A CB  1 
ATOM   1495 C CG1 . ILE A 1 200 ? -13.93363 -19.18790 3.09128   1.000 41.15265 ? 200 ILE A CG1 1 
ATOM   1496 C CG2 . ILE A 1 200 ? -13.61641 -20.90807 4.85446   1.000 35.63259 ? 200 ILE A CG2 1 
ATOM   1497 C CD1 . ILE A 1 200 ? -14.69319 -18.02862 3.67321   1.000 37.48522 ? 200 ILE A CD1 1 
ATOM   1498 N N   . THR A 1 201 ? -14.24205 -24.06683 2.55021   1.000 41.38467 ? 201 THR A N   1 
ATOM   1499 C CA  . THR A 1 201 ? -14.79933 -25.40353 2.76947   1.000 40.75810 ? 201 THR A CA  1 
ATOM   1500 C C   . THR A 1 201 ? -15.14094 -25.64322 4.22657   1.000 41.31849 ? 201 THR A C   1 
ATOM   1501 O O   . THR A 1 201 ? -16.24763 -26.09260 4.55552   1.000 43.66843 ? 201 THR A O   1 
ATOM   1502 C CB  . THR A 1 201 ? -13.81076 -26.45927 2.28674   1.000 38.11748 ? 201 THR A CB  1 
ATOM   1503 O OG1 . THR A 1 201 ? -13.33678 -26.07715 0.99592   1.000 37.99279 ? 201 THR A OG1 1 
ATOM   1504 C CG2 . THR A 1 201 ? -14.51429 -27.85673 2.18649   1.000 38.35669 ? 201 THR A CG2 1 
ATOM   1505 N N   . VAL A 1 202 ? -14.18879 -25.38315 5.12270   1.000 36.78304 ? 202 VAL A N   1 
ATOM   1506 C CA  . VAL A 1 202 ? -14.43711 -25.68548 6.52726   1.000 41.13534 ? 202 VAL A CA  1 
ATOM   1507 C C   . VAL A 1 202 ? -15.73635 -25.03265 6.99254   1.000 43.39401 ? 202 VAL A C   1 
ATOM   1508 O O   . VAL A 1 202 ? -16.51697 -25.63042 7.73684   1.000 38.41894 ? 202 VAL A O   1 
ATOM   1509 C CB  . VAL A 1 202 ? -13.23822 -25.26424 7.39153   1.000 41.82816 ? 202 VAL A CB  1 
ATOM   1510 C CG1 . VAL A 1 202 ? -12.88042 -23.75431 7.15924   1.000 44.38127 ? 202 VAL A CG1 1 
ATOM   1511 C CG2 . VAL A 1 202 ? -13.52339 -25.57692 8.86002   1.000 45.66408 ? 202 VAL A CG2 1 
ATOM   1512 N N   . ASN A 1 203 ? -15.99504 -23.80381 6.54383   1.000 43.99310 ? 203 ASN A N   1 
ATOM   1513 C CA  . ASN A 1 203 ? -17.22482 -23.11989 6.92421   1.000 41.38920 ? 203 ASN A CA  1 
ATOM   1514 C C   . ASN A 1 203 ? -18.45315 -23.77319 6.30005   1.000 37.49003 ? 203 ASN A C   1 
ATOM   1515 O O   . ASN A 1 203 ? -19.51850 -23.81220 6.92416   1.000 37.66169 ? 203 ASN A O   1 
ATOM   1516 C CB  . ASN A 1 203 ? -17.15217 -21.64826 6.52141   1.000 38.55279 ? 203 ASN A CB  1 
ATOM   1517 C CG  . ASN A 1 203 ? -16.19312 -20.84250 7.39441   1.000 40.87347 ? 203 ASN A CG  1 
ATOM   1518 O OD1 . ASN A 1 203 ? -15.51661 -21.38129 8.27632   1.000 36.13617 ? 203 ASN A OD1 1 
ATOM   1519 N ND2 . ASN A 1 203 ? -16.14068 -19.52996 7.14965   1.000 41.98313 ? 203 ASN A ND2 1 
ATOM   1520 N N   . VAL A 1 204 ? -18.35804 -24.21856 5.04659   1.000 39.17933 ? 204 VAL A N   1 
ATOM   1521 C CA  . VAL A 1 204 ? -19.51219 -24.87095 4.44855   1.000 41.66485 ? 204 VAL A CA  1 
ATOM   1522 C C   . VAL A 1 204 ? -19.90735 -26.06916 5.29455   1.000 40.29418 ? 204 VAL A C   1 
ATOM   1523 O O   . VAL A 1 204 ? -21.08457 -26.26798 5.59471   1.000 36.81422 ? 204 VAL A O   1 
ATOM   1524 C CB  . VAL A 1 204 ? -19.23550 -25.26965 2.99081   1.000 42.28585 ? 204 VAL A CB  1 
ATOM   1525 C CG1 . VAL A 1 204 ? -20.36585 -26.13672 2.47586   1.000 43.73457 ? 204 VAL A CG1 1 
ATOM   1526 C CG2 . VAL A 1 204 ? -19.07644 -24.02182 2.11592   1.000 41.72129 ? 204 VAL A CG2 1 
ATOM   1527 N N   . LEU A 1 205 ? -18.91348 -26.83893 5.74866   1.000 41.70613 ? 205 LEU A N   1 
ATOM   1528 C CA  . LEU A 1 205 ? -19.16692 -27.98142 6.61893   1.000 43.89181 ? 205 LEU A CA  1 
ATOM   1529 C C   . LEU A 1 205 ? -19.76382 -27.54989 7.95441   1.000 41.24514 ? 205 LEU A C   1 
ATOM   1530 O O   . LEU A 1 205 ? -20.68564 -28.20341 8.47170   1.000 39.51575 ? 205 LEU A O   1 
ATOM   1531 C CB  . LEU A 1 205 ? -17.86057 -28.75353 6.82765   1.000 42.19919 ? 205 LEU A CB  1 
ATOM   1532 C CG  . LEU A 1 205 ? -17.30345 -29.45279 5.59391   1.000 44.55844 ? 205 LEU A CG  1 
ATOM   1533 C CD1 . LEU A 1 205 ? -15.88133 -29.98089 5.82983   1.000 39.39220 ? 205 LEU A CD1 1 
ATOM   1534 C CD2 . LEU A 1 205 ? -18.25183 -30.58886 5.19984   1.000 40.06512 ? 205 LEU A CD2 1 
ATOM   1535 N N   . ALA A 1 206 ? -19.24597 -26.45877 8.54121   1.000 37.31594 ? 206 ALA A N   1 
ATOM   1536 C CA  . ALA A 1 206 ? -19.80211 -25.97593 9.80745   1.000 35.59673 ? 206 ALA A CA  1 
ATOM   1537 C C   . ALA A 1 206 ? -21.28870 -25.69493 9.65963   1.000 38.81534 ? 206 ALA A C   1 
ATOM   1538 O O   . ALA A 1 206 ? -22.08811 -25.96378 10.57023  1.000 40.66284 ? 206 ALA A O   1 
ATOM   1539 C CB  . ALA A 1 206 ? -19.06518 -24.71271 10.27096  1.000 41.02516 ? 206 ALA A CB  1 
ATOM   1540 N N   . TRP A 1 207 ? -21.67522 -25.18404 8.49751   1.000 36.71331 ? 207 TRP A N   1 
ATOM   1541 C CA  . TRP A 1 207 ? -23.04663 -24.78345 8.24387   1.000 38.64311 ? 207 TRP A CA  1 
ATOM   1542 C C   . TRP A 1 207 ? -23.94829 -25.99858 7.98422   1.000 40.31069 ? 207 TRP A C   1 
ATOM   1543 O O   . TRP A 1 207 ? -25.08076 -26.05559 8.48605   1.000 35.45297 ? 207 TRP A O   1 
ATOM   1544 C CB  . TRP A 1 207 ? -23.01547 -23.79766 7.08297   1.000 31.94224 ? 207 TRP A CB  1 
ATOM   1545 C CG  . TRP A 1 207 ? -24.29323 -23.36694 6.50217   1.000 33.84213 ? 207 TRP A CG  1 
ATOM   1546 C CD1 . TRP A 1 207 ? -25.15187 -22.42037 6.98856   1.000 35.49617 ? 207 TRP A CD1 1 
ATOM   1547 C CD2 . TRP A 1 207 ? -24.84898 -23.82320 5.27100   1.000 36.95189 ? 207 TRP A CD2 1 
ATOM   1548 N NE1 . TRP A 1 207 ? -26.21552 -22.27026 6.12971   1.000 36.74426 ? 207 TRP A NE1 1 
ATOM   1549 C CE2 . TRP A 1 207 ? -26.04841 -23.12199 5.06865   1.000 34.75115 ? 207 TRP A CE2 1 
ATOM   1550 C CE3 . TRP A 1 207 ? -24.44445 -24.76361 4.31587   1.000 36.26145 ? 207 TRP A CE3 1 
ATOM   1551 C CZ2 . TRP A 1 207 ? -26.83865 -23.32183 3.95692   1.000 39.02512 ? 207 TRP A CZ2 1 
ATOM   1552 C CZ3 . TRP A 1 207 ? -25.23685 -24.96216 3.21130   1.000 39.16246 ? 207 TRP A CZ3 1 
ATOM   1553 C CH2 . TRP A 1 207 ? -26.42571 -24.25206 3.04588   1.000 39.90169 ? 207 TRP A CH2 1 
ATOM   1554 N N   . LEU A 1 208 ? -23.45758 -26.98587 7.22468   1.000 40.48245 ? 208 LEU A N   1 
ATOM   1555 C CA  . LEU A 1 208 ? -24.15270 -28.26960 7.13945   1.000 38.31913 ? 208 LEU A CA  1 
ATOM   1556 C C   . LEU A 1 208 ? -24.40272 -28.85006 8.52301   1.000 40.62721 ? 208 LEU A C   1 
ATOM   1557 O O   . LEU A 1 208 ? -25.47371 -29.41604 8.78329   1.000 41.25845 ? 208 LEU A O   1 
ATOM   1558 C CB  . LEU A 1 208 ? -23.35328 -29.24593 6.27586   1.000 39.72383 ? 208 LEU A CB  1 
ATOM   1559 C CG  . LEU A 1 208 ? -23.25993 -28.83748 4.80438   1.000 35.23802 ? 208 LEU A CG  1 
ATOM   1560 C CD1 . LEU A 1 208 ? -22.52366 -29.87277 3.99078   1.000 40.21663 ? 208 LEU A CD1 1 
ATOM   1561 C CD2 . LEU A 1 208 ? -24.63726 -28.58430 4.21365   1.000 38.51052 ? 208 LEU A CD2 1 
ATOM   1562 N N   . TYR A 1 209 ? -23.43707 -28.70307 9.43970   1.000 38.53263 ? 209 TYR A N   1 
ATOM   1563 C CA  . TYR A 1 209 ? -23.66905 -29.15503 10.80952  1.000 41.73698 ? 209 TYR A CA  1 
ATOM   1564 C C   . TYR A 1 209 ? -24.79185 -28.36909 11.47523  1.000 44.56781 ? 209 TYR A C   1 
ATOM   1565 O O   . TYR A 1 209 ? -25.65234 -28.95236 12.15041  1.000 36.70926 ? 209 TYR A O   1 
ATOM   1566 C CB  . TYR A 1 209 ? -22.39451 -29.06405 11.63874  1.000 40.30966 ? 209 TYR A CB  1 
ATOM   1567 C CG  . TYR A 1 209 ? -21.51216 -30.27668 11.47273  1.000 42.97827 ? 209 TYR A CG  1 
ATOM   1568 C CD1 . TYR A 1 209 ? -21.89894 -31.51912 11.99203  1.000 45.91408 ? 209 TYR A CD1 1 
ATOM   1569 C CD2 . TYR A 1 209 ? -20.30015 -30.19345 10.79430  1.000 41.41958 ? 209 TYR A CD2 1 
ATOM   1570 C CE1 . TYR A 1 209 ? -21.10651 -32.64370 11.83543  1.000 44.55882 ? 209 TYR A CE1 1 
ATOM   1571 C CE2 . TYR A 1 209 ? -19.49073 -31.31508 10.63122  1.000 44.40364 ? 209 TYR A CE2 1 
ATOM   1572 C CZ  . TYR A 1 209 ? -19.90432 -32.54072 11.15460  1.000 48.11078 ? 209 TYR A CZ  1 
ATOM   1573 O OH  . TYR A 1 209 ? -19.11370 -33.64833 10.99449  1.000 48.31264 ? 209 TYR A OH  1 
ATOM   1574 N N   . ALA A 1 210 ? -24.79483 -27.04124 11.31573  1.000 39.91951 ? 210 ALA A N   1 
ATOM   1575 C CA  . ALA A 1 210 ? -25.90161 -26.25609 11.85376  1.000 42.70535 ? 210 ALA A CA  1 
ATOM   1576 C C   . ALA A 1 210 ? -27.23403 -26.75269 11.30920  1.000 37.79507 ? 210 ALA A C   1 
ATOM   1577 O O   . ALA A 1 210 ? -28.24588 -26.73891 12.01650  1.000 39.04363 ? 210 ALA A O   1 
ATOM   1578 C CB  . ALA A 1 210 ? -25.72175 -24.77249 11.52567  1.000 34.53767 ? 210 ALA A CB  1 
ATOM   1579 N N   . ALA A 1 211 ? -27.25632 -27.14517 10.03630  1.000 37.36752 ? 211 ALA A N   1 
ATOM   1580 C CA  . ALA A 1 211 ? -28.48516 -27.60769 9.41858   1.000 37.43623 ? 211 ALA A CA  1 
ATOM   1581 C C   . ALA A 1 211 ? -28.98350 -28.88819 10.08568  1.000 41.03421 ? 211 ALA A C   1 
ATOM   1582 O O   . ALA A 1 211 ? -30.18519 -29.04524 10.31592  1.000 42.16630 ? 211 ALA A O   1 
ATOM   1583 C CB  . ALA A 1 211 ? -28.26506 -27.82039 7.91964   1.000 31.96067 ? 211 ALA A CB  1 
ATOM   1584 N N   . VAL A 1 212 ? -28.06881 -29.79051 10.43769  1.000 39.32890 ? 212 VAL A N   1 
ATOM   1585 C CA  . VAL A 1 212 ? -28.44876 -31.00526 11.14970  1.000 43.19065 ? 212 VAL A CA  1 
ATOM   1586 C C   . VAL A 1 212 ? -28.88079 -30.67087 12.57308  1.000 48.15283 ? 212 VAL A C   1 
ATOM   1587 O O   . VAL A 1 212 ? -29.92465 -31.14259 13.05482  1.000 38.84441 ? 212 VAL A O   1 
ATOM   1588 C CB  . VAL A 1 212 ? -27.29165 -32.02313 11.11167  1.000 38.95832 ? 212 VAL A CB  1 
ATOM   1589 C CG1 . VAL A 1 212 ? -27.64869 -33.28760 11.89960  1.000 47.95382 ? 212 VAL A CG1 1 
ATOM   1590 C CG2 . VAL A 1 212 ? -26.98010 -32.37213 9.66478   1.000 40.46440 ? 212 VAL A CG2 1 
ATOM   1591 N N   . ILE A 1 213 ? -28.10536 -29.82569 13.26043  1.000 41.36826 ? 213 ILE A N   1 
ATOM   1592 C CA  . ILE A 1 213 ? -28.47343 -29.44760 14.62503  1.000 42.56009 ? 213 ILE A CA  1 
ATOM   1593 C C   . ILE A 1 213 ? -29.89917 -28.91723 14.65848  1.000 46.99879 ? 213 ILE A C   1 
ATOM   1594 O O   . ILE A 1 213 ? -30.66335 -29.19758 15.59156  1.000 45.11954 ? 213 ILE A O   1 
ATOM   1595 C CB  . ILE A 1 213 ? -27.47771 -28.42123 15.19718  1.000 41.83972 ? 213 ILE A CB  1 
ATOM   1596 C CG1 . ILE A 1 213 ? -26.10681 -29.06507 15.42380  1.000 48.87529 ? 213 ILE A CG1 1 
ATOM   1597 C CG2 . ILE A 1 213 ? -28.00953 -27.81090 16.49638  1.000 44.90507 ? 213 ILE A CG2 1 
ATOM   1598 C CD1 . ILE A 1 213 ? -25.12283 -28.17141 16.16631  1.000 45.56665 ? 213 ILE A CD1 1 
ATOM   1599 N N   . ASN A 1 214 ? -30.28808 -28.15849 13.63427  1.000 43.66845 ? 214 ASN A N   1 
ATOM   1600 C CA  . ASN A 1 214 ? -31.60780 -27.54713 13.60868  1.000 45.21131 ? 214 ASN A CA  1 
ATOM   1601 C C   . ASN A 1 214 ? -32.67447 -28.46068 12.99757  1.000 47.89166 ? 214 ASN A C   1 
ATOM   1602 O O   . ASN A 1 214 ? -33.75423 -27.97567 12.63745  1.000 47.94869 ? 214 ASN A O   1 
ATOM   1603 C CB  . ASN A 1 214 ? -31.55464 -26.19893 12.87738  1.000 43.63230 ? 214 ASN A CB  1 
ATOM   1604 C CG  . ASN A 1 214 ? -30.88695 -25.10786 13.71804  1.000 46.93483 ? 214 ASN A CG  1 
ATOM   1605 O OD1 . ASN A 1 214 ? -31.56196 -24.35495 14.41501  1.000 53.66464 ? 214 ASN A OD1 1 
ATOM   1606 N ND2 . ASN A 1 214 ? -29.55162 -25.04037 13.67026  1.000 50.04094 ? 214 ASN A ND2 1 
ATOM   1607 N N   . GLY A 1 215 ? -32.39668 -29.75994 12.87482  1.000 45.39283 ? 215 GLY A N   1 
ATOM   1608 C CA  . GLY A 1 215 ? -33.41292 -30.74056 12.54085  1.000 48.01310 ? 215 GLY A CA  1 
ATOM   1609 C C   . GLY A 1 215 ? -33.47949 -31.18640 11.09500  1.000 53.60064 ? 215 GLY A C   1 
ATOM   1610 O O   . GLY A 1 215 ? -34.39970 -31.93387 10.74522  1.000 54.94615 ? 215 GLY A O   1 
ATOM   1611 N N   . ASP A 1 216 ? -32.52883 -30.78855 10.25046  1.000 48.61445 ? 216 ASP A N   1 
ATOM   1612 C CA  . ASP A 1 216 ? -32.58168 -31.09609 8.82462   1.000 51.52365 ? 216 ASP A CA  1 
ATOM   1613 C C   . ASP A 1 216 ? -31.48897 -32.09537 8.43311   1.000 54.61092 ? 216 ASP A C   1 
ATOM   1614 O O   . ASP A 1 216 ? -30.31417 -31.88405 8.75044   1.000 46.16241 ? 216 ASP A O   1 
ATOM   1615 C CB  . ASP A 1 216 ? -32.44332 -29.81414 8.00820   1.000 47.31345 ? 216 ASP A CB  1 
ATOM   1616 C CG  . ASP A 1 216 ? -32.94323 -29.98008 6.60214   1.000 57.21963 ? 216 ASP A CG  1 
ATOM   1617 O OD1 . ASP A 1 216 ? -33.44797 -31.08422 6.30747   1.000 54.18175 ? 216 ASP A OD1 1 
ATOM   1618 O OD2 . ASP A 1 216 ? -32.83381 -29.01881 5.79902   1.000 59.70134 ? 216 ASP A OD2 1 
ATOM   1619 N N   . ARG A 1 217 ? -31.87738 -33.17719 7.71259   1.000 50.29993 ? 217 ARG A N   1 
ATOM   1620 C CA  . ARG A 1 217 ? -30.93946 -34.23623 7.34628   1.000 45.46582 ? 217 ARG A CA  1 
ATOM   1621 C C   . ARG A 1 217 ? -31.03608 -34.70595 5.89386   1.000 44.93713 ? 217 ARG A C   1 
ATOM   1622 O O   . ARG A 1 217 ? -30.37624 -35.69529 5.54422   1.000 43.42462 ? 217 ARG A O   1 
ATOM   1623 C CB  . ARG A 1 217 ? -31.12264 -35.46706 8.25452   1.000 51.40503 ? 217 ARG A CB  1 
ATOM   1624 C CG  . ARG A 1 217 ? -30.84962 -35.24694 9.73654   1.000 50.34837 ? 217 ARG A CG  1 
ATOM   1625 C CD  . ARG A 1 217 ? -31.19014 -36.52036 10.52000  1.000 48.93673 ? 217 ARG A CD  1 
ATOM   1626 N NE  . ARG A 1 217 ? -30.38684 -37.65439 10.07730  1.000 47.90311 ? 217 ARG A NE  1 
ATOM   1627 C CZ  . ARG A 1 217 ? -29.34103 -38.13660 10.73213  1.000 44.96326 ? 217 ARG A CZ  1 
ATOM   1628 N NH1 . ARG A 1 217 ? -28.97080 -37.64245 11.90041  1.000 48.00812 ? 217 ARG A NH1 1 
ATOM   1629 N NH2 . ARG A 1 217 ? -28.63759 -39.12936 10.19256  1.000 47.30841 ? 217 ARG A NH2 1 
ATOM   1630 N N   . TRP A 1 218 ? -31.79808 -34.02643 5.02719   1.000 44.57069 ? 218 TRP A N   1 
ATOM   1631 C CA  . TRP A 1 218 ? -32.11474 -34.58972 3.71206   1.000 40.51640 ? 218 TRP A CA  1 
ATOM   1632 C C   . TRP A 1 218 ? -30.87665 -34.81301 2.85919   1.000 44.50741 ? 218 TRP A C   1 
ATOM   1633 O O   . TRP A 1 218 ? -30.88544 -35.67833 1.97228   1.000 43.47218 ? 218 TRP A O   1 
ATOM   1634 C CB  . TRP A 1 218 ? -33.09806 -33.68683 2.95313   1.000 42.94236 ? 218 TRP A CB  1 
ATOM   1635 C CG  . TRP A 1 218 ? -32.53141 -32.32808 2.47994   1.000 44.37941 ? 218 TRP A CG  1 
ATOM   1636 C CD1 . TRP A 1 218 ? -32.71443 -31.11065 3.08506   1.000 43.71352 ? 218 TRP A CD1 1 
ATOM   1637 C CD2 . TRP A 1 218 ? -31.76314 -32.06731 1.29324   1.000 42.03236 ? 218 TRP A CD2 1 
ATOM   1638 N NE1 . TRP A 1 218 ? -32.08742 -30.11760 2.36162   1.000 43.47492 ? 218 TRP A NE1 1 
ATOM   1639 C CE2 . TRP A 1 218 ? -31.49528 -30.67212 1.26147   1.000 42.92814 ? 218 TRP A CE2 1 
ATOM   1640 C CE3 . TRP A 1 218 ? -31.25618 -32.87196 0.26665   1.000 44.24932 ? 218 TRP A CE3 1 
ATOM   1641 C CZ2 . TRP A 1 218 ? -30.75015 -30.07065 0.24087   1.000 48.35767 ? 218 TRP A CZ2 1 
ATOM   1642 C CZ3 . TRP A 1 218 ? -30.51285 -32.27370 -0.74735  1.000 48.25805 ? 218 TRP A CZ3 1 
ATOM   1643 C CH2 . TRP A 1 218 ? -30.26667 -30.88049 -0.75164  1.000 50.04578 ? 218 TRP A CH2 1 
ATOM   1644 N N   . PHE A 1 219 ? -29.81705 -34.03104 3.08880   1.000 41.01653 ? 219 PHE A N   1 
ATOM   1645 C CA  . PHE A 1 219 ? -28.61034 -34.06676 2.27629   1.000 40.02449 ? 219 PHE A CA  1 
ATOM   1646 C C   . PHE A 1 219 ? -27.59664 -35.10386 2.74858   1.000 40.07913 ? 219 PHE A C   1 
ATOM   1647 O O   . PHE A 1 219 ? -26.61379 -35.35286 2.04186   1.000 42.44511 ? 219 PHE A O   1 
ATOM   1648 C CB  . PHE A 1 219 ? -27.95639 -32.66655 2.28248   1.000 37.77669 ? 219 PHE A CB  1 
ATOM   1649 C CG  . PHE A 1 219 ? -27.86871 -32.07493 3.65778   1.000 36.59144 ? 219 PHE A CG  1 
ATOM   1650 C CD1 . PHE A 1 219 ? -26.82436 -32.41121 4.50145   1.000 36.00468 ? 219 PHE A CD1 1 
ATOM   1651 C CD2 . PHE A 1 219 ? -28.88599 -31.26893 4.14499   1.000 36.23071 ? 219 PHE A CD2 1 
ATOM   1652 C CE1 . PHE A 1 219 ? -26.77123 -31.90398 5.79495   1.000 39.15273 ? 219 PHE A CE1 1 
ATOM   1653 C CE2 . PHE A 1 219 ? -28.83942 -30.76469 5.43332   1.000 36.83967 ? 219 PHE A CE2 1 
ATOM   1654 C CZ  . PHE A 1 219 ? -27.76873 -31.06890 6.25457   1.000 35.94285 ? 219 PHE A CZ  1 
ATOM   1655 N N   . LEU A 1 220 ? -27.77501 -35.68667 3.92956   1.000 43.23212 ? 220 LEU A N   1 
ATOM   1656 C CA  . LEU A 1 220 ? -26.84890 -36.72795 4.36345   1.000 46.29458 ? 220 LEU A CA  1 
ATOM   1657 C C   . LEU A 1 220 ? -26.93134 -37.93571 3.42548   1.000 44.45697 ? 220 LEU A C   1 
ATOM   1658 O O   . LEU A 1 220 ? -27.85333 -38.06155 2.61851   1.000 41.61728 ? 220 LEU A O   1 
ATOM   1659 C CB  . LEU A 1 220 ? -27.13408 -37.14138 5.80916   1.000 42.88533 ? 220 LEU A CB  1 
ATOM   1660 C CG  . LEU A 1 220 ? -26.97813 -36.03570 6.85654   1.000 43.57533 ? 220 LEU A CG  1 
ATOM   1661 C CD1 . LEU A 1 220 ? -27.11613 -36.62151 8.25975   1.000 43.69837 ? 220 LEU A CD1 1 
ATOM   1662 C CD2 . LEU A 1 220 ? -25.63521 -35.28616 6.69105   1.000 42.19985 ? 220 LEU A CD2 1 
ATOM   1663 N N   . ASN A 1 221 ? -25.90842 -38.79382 3.48586   1.000 46.42431 ? 221 ASN A N   1 
ATOM   1664 C CA  . ASN A 1 221 ? -25.89522 -40.03543 2.71639   1.000 41.58766 ? 221 ASN A CA  1 
ATOM   1665 C C   . ASN A 1 221 ? -25.13196 -41.09059 3.49979   1.000 44.00657 ? 221 ASN A C   1 
ATOM   1666 O O   . ASN A 1 221 ? -24.57394 -40.81935 4.56766   1.000 39.26362 ? 221 ASN A O   1 
ATOM   1667 C CB  . ASN A 1 221 ? -25.30356 -39.85628 1.30702   1.000 43.57418 ? 221 ASN A CB  1 
ATOM   1668 C CG  . ASN A 1 221 ? -23.82630 -39.40819 1.31661   1.000 51.23363 ? 221 ASN A CG  1 
ATOM   1669 O OD1 . ASN A 1 221 ? -23.02315 -39.83356 2.15528   1.000 49.97100 ? 221 ASN A OD1 1 
ATOM   1670 N ND2 . ASN A 1 221 ? -23.47538 -38.54012 0.37241   1.000 44.35315 ? 221 ASN A ND2 1 
ATOM   1671 N N   . ARG A 1 222 ? -25.17081 -42.32779 2.98611   1.000 50.93425 ? 222 ARG A N   1 
ATOM   1672 C CA  . ARG A 1 222 ? -24.51104 -43.45245 3.64574   1.000 52.05573 ? 222 ARG A CA  1 
ATOM   1673 C C   . ARG A 1 222 ? -23.04158 -43.56809 3.26562   1.000 52.16733 ? 222 ARG A C   1 
ATOM   1674 O O   . ARG A 1 222 ? -22.32363 -44.39854 3.83242   1.000 53.54267 ? 222 ARG A O   1 
ATOM   1675 C CB  . ARG A 1 222 ? -25.22968 -44.77454 3.32329   1.000 52.10454 ? 222 ARG A CB  1 
ATOM   1676 C CG  . ARG A 1 222 ? -25.44857 -45.05056 1.83273   1.000 50.41799 ? 222 ARG A CG  1 
ATOM   1677 C CD  . ARG A 1 222 ? -25.12184 -46.50765 1.46158   1.000 55.36807 ? 222 ARG A CD  1 
ATOM   1678 N NE  . ARG A 1 222 ? -25.54355 -46.81220 0.09847   1.000 59.24136 ? 222 ARG A NE  1 
ATOM   1679 C CZ  . ARG A 1 222 ? -24.87093 -47.58426 -0.74701  1.000 64.72731 ? 222 ARG A CZ  1 
ATOM   1680 N NH1 . ARG A 1 222 ? -23.74091 -48.17747 -0.39263  1.000 63.99932 ? 222 ARG A NH1 1 
ATOM   1681 N NH2 . ARG A 1 222 ? -25.33889 -47.75719 -1.98315  1.000 60.93372 ? 222 ARG A NH2 1 
ATOM   1682 N N   . PHE A 1 223 ? -22.57042 -42.73910 2.34585   1.000 52.63823 ? 223 PHE A N   1 
ATOM   1683 C CA  . PHE A 1 223 ? -21.22268 -42.88633 1.82300   1.000 50.46693 ? 223 PHE A CA  1 
ATOM   1684 C C   . PHE A 1 223 ? -20.20581 -42.23461 2.75145   1.000 52.58000 ? 223 PHE A C   1 
ATOM   1685 O O   . PHE A 1 223 ? -20.53999 -41.60032 3.75755   1.000 47.55982 ? 223 PHE A O   1 
ATOM   1686 C CB  . PHE A 1 223 ? -21.15852 -42.31614 0.41265   1.000 50.73588 ? 223 PHE A CB  1 
ATOM   1687 C CG  . PHE A 1 223 ? -22.10870 -42.99143 -0.52836  1.000 58.18303 ? 223 PHE A CG  1 
ATOM   1688 C CD1 . PHE A 1 223 ? -21.87297 -44.29519 -0.94836  1.000 57.80141 ? 223 PHE A CD1 1 
ATOM   1689 C CD2 . PHE A 1 223 ? -23.26186 -42.34979 -0.95676  1.000 58.11797 ? 223 PHE A CD2 1 
ATOM   1690 C CE1 . PHE A 1 223 ? -22.74973 -44.93538 -1.80358  1.000 56.26174 ? 223 PHE A CE1 1 
ATOM   1691 C CE2 . PHE A 1 223 ? -24.14761 -42.98800 -1.81393  1.000 59.07875 ? 223 PHE A CE2 1 
ATOM   1692 C CZ  . PHE A 1 223 ? -23.88726 -44.28435 -2.23911  1.000 60.14756 ? 223 PHE A CZ  1 
ATOM   1693 N N   . THR A 1 224 ? -18.93525 -42.40664 2.41265   1.000 56.73286 ? 224 THR A N   1 
ATOM   1694 C CA  . THR A 1 224 ? -17.86825 -41.74789 3.14147   1.000 54.79606 ? 224 THR A CA  1 
ATOM   1695 C C   . THR A 1 224 ? -16.75192 -41.44569 2.15191   1.000 53.29744 ? 224 THR A C   1 
ATOM   1696 O O   . THR A 1 224 ? -16.90514 -41.64630 0.94226   1.000 58.01902 ? 224 THR A O   1 
ATOM   1697 C CB  . THR A 1 224 ? -17.40296 -42.60942 4.31852   1.000 56.10673 ? 224 THR A CB  1 
ATOM   1698 O OG1 . THR A 1 224 ? -16.66191 -41.79702 5.23473   1.000 57.57297 ? 224 THR A OG1 1 
ATOM   1699 C CG2 . THR A 1 224 ? -16.52189 -43.74732 3.81795   1.000 54.85040 ? 224 THR A CG2 1 
ATOM   1700 N N   . THR A 1 225 ? -15.62029 -40.97025 2.66634   1.000 56.57644 ? 225 THR A N   1 
ATOM   1701 C CA  . THR A 1 225 ? -14.56399 -40.47612 1.78922   1.000 55.35085 ? 225 THR A CA  1 
ATOM   1702 C C   . THR A 1 225 ? -13.30618 -40.19986 2.60901   1.000 53.34304 ? 225 THR A C   1 
ATOM   1703 O O   . THR A 1 225 ? -13.37863 -39.86507 3.79890   1.000 54.26948 ? 225 THR A O   1 
ATOM   1704 C CB  . THR A 1 225 ? -15.02757 -39.20999 1.04747   1.000 52.79641 ? 225 THR A CB  1 
ATOM   1705 O OG1 . THR A 1 225 ? -14.08476 -38.85617 0.03008   1.000 55.16123 ? 225 THR A OG1 1 
ATOM   1706 C CG2 . THR A 1 225 ? -15.18182 -38.04550 2.01626   1.000 52.46617 ? 225 THR A CG2 1 
ATOM   1707 N N   . THR A 1 226 ? -12.15391 -40.36595 1.96492   1.000 56.40017 ? 226 THR A N   1 
ATOM   1708 C CA  . THR A 1 226 ? -10.87941 -39.96801 2.54996   1.000 59.30985 ? 226 THR A CA  1 
ATOM   1709 C C   . THR A 1 226 ? -10.63408 -38.48211 2.31135   1.000 53.52986 ? 226 THR A C   1 
ATOM   1710 O O   . THR A 1 226 ? -11.09735 -37.90166 1.32370   1.000 52.24985 ? 226 THR A O   1 
ATOM   1711 C CB  . THR A 1 226 ? -9.71365  -40.77297 1.96130   1.000 54.69952 ? 226 THR A CB  1 
ATOM   1712 O OG1 . THR A 1 226 ? -9.66986  -40.59249 0.53393   1.000 51.98427 ? 226 THR A OG1 1 
ATOM   1713 C CG2 . THR A 1 226 ? -9.86722  -42.25420 2.28481   1.000 55.72954 ? 226 THR A CG2 1 
ATOM   1714 N N   . LEU A 1 227 ? -9.88794  -37.87392 3.23045   1.000 51.32777 ? 227 LEU A N   1 
ATOM   1715 C CA  . LEU A 1 227 ? -9.52730  -36.46995 3.08435   1.000 52.37218 ? 227 LEU A CA  1 
ATOM   1716 C C   . LEU A 1 227 ? -8.99393  -36.18140 1.68417   1.000 53.45635 ? 227 LEU A C   1 
ATOM   1717 O O   . LEU A 1 227 ? -9.50276  -35.30154 0.98079   1.000 54.50274 ? 227 LEU A O   1 
ATOM   1718 C CB  . LEU A 1 227 ? -8.51244  -36.09728 4.16073   1.000 48.79043 ? 227 LEU A CB  1 
ATOM   1719 C CG  . LEU A 1 227 ? -8.33572  -34.61358 4.46635   1.000 54.24796 ? 227 LEU A CG  1 
ATOM   1720 C CD1 . LEU A 1 227 ? -9.66177  -33.87430 4.30772   1.000 50.76693 ? 227 LEU A CD1 1 
ATOM   1721 C CD2 . LEU A 1 227 ? -7.78351  -34.45273 5.88148   1.000 53.68732 ? 227 LEU A CD2 1 
ATOM   1722 N N   . ASN A 1 228 ? -7.97646  -36.92605 1.24748   1.000 58.62078 ? 228 ASN A N   1 
ATOM   1723 C CA  . ASN A 1 228 ? -7.44612  -36.69090 -0.09277  1.000 54.08858 ? 228 ASN A CA  1 
ATOM   1724 C C   . ASN A 1 228 ? -8.53734  -36.86244 -1.14278  1.000 57.22008 ? 228 ASN A C   1 
ATOM   1725 O O   . ASN A 1 228 ? -8.65275  -36.04988 -2.06914  1.000 54.02013 ? 228 ASN A O   1 
ATOM   1726 C CB  . ASN A 1 228 ? -6.26506  -37.62290 -0.37509  1.000 58.84021 ? 228 ASN A CB  1 
ATOM   1727 N N   . ASP A 1 229 ? -9.37300  -37.89848 -0.99688  1.000 58.36980 ? 229 ASP A N   1 
ATOM   1728 C CA  . ASP A 1 229 ? -10.43189 -38.12957 -1.97753  1.000 54.94070 ? 229 ASP A CA  1 
ATOM   1729 C C   . ASP A 1 229 ? -11.44139 -36.98803 -1.97513  1.000 53.52672 ? 229 ASP A C   1 
ATOM   1730 O O   . ASP A 1 229 ? -11.91607 -36.56102 -3.03646  1.000 52.65265 ? 229 ASP A O   1 
ATOM   1731 C CB  . ASP A 1 229 ? -11.12271 -39.46790 -1.70592  1.000 58.44469 ? 229 ASP A CB  1 
ATOM   1732 C CG  . ASP A 1 229 ? -10.45421 -40.62417 -2.42869  1.000 62.13568 ? 229 ASP A CG  1 
ATOM   1733 O OD1 . ASP A 1 229 ? -9.47824  -40.38321 -3.17851  1.000 59.08093 ? 229 ASP A OD1 1 
ATOM   1734 O OD2 . ASP A 1 229 ? -10.90625 -41.77370 -2.25102  1.000 64.18373 ? 229 ASP A OD2 1 
ATOM   1735 N N   . PHE A 1 230 ? -11.77811 -36.47252 -0.79304  1.000 50.63245 ? 230 PHE A N   1 
ATOM   1736 C CA  . PHE A 1 230 ? -12.62335 -35.28326 -0.74062  1.000 55.44274 ? 230 PHE A CA  1 
ATOM   1737 C C   . PHE A 1 230 ? -11.94803 -34.09169 -1.41808  1.000 50.37231 ? 230 PHE A C   1 
ATOM   1738 O O   . PHE A 1 230 ? -12.54072 -33.44462 -2.28741  1.000 51.91112 ? 230 PHE A O   1 
ATOM   1739 C CB  . PHE A 1 230 ? -12.98596 -34.93948 0.70276   1.000 53.70229 ? 230 PHE A CB  1 
ATOM   1740 C CG  . PHE A 1 230 ? -13.69641 -33.62281 0.83450   1.000 53.59272 ? 230 PHE A CG  1 
ATOM   1741 C CD1 . PHE A 1 230 ? -15.05009 -33.51501 0.52254   1.000 50.63548 ? 230 PHE A CD1 1 
ATOM   1742 C CD2 . PHE A 1 230 ? -13.00975 -32.49077 1.24443   1.000 51.54466 ? 230 PHE A CD2 1 
ATOM   1743 C CE1 . PHE A 1 230 ? -15.70708 -32.30776 0.62740   1.000 48.02642 ? 230 PHE A CE1 1 
ATOM   1744 C CE2 . PHE A 1 230 ? -13.65813 -31.26785 1.34920   1.000 52.31879 ? 230 PHE A CE2 1 
ATOM   1745 C CZ  . PHE A 1 230 ? -15.00883 -31.17730 1.04214   1.000 52.87753 ? 230 PHE A CZ  1 
ATOM   1746 N N   . ASN A 1 231 ? -10.69735 -33.79841 -1.04921  1.000 51.75722 ? 231 ASN A N   1 
ATOM   1747 C CA  . ASN A 1 231 ? -10.03088 -32.60582 -1.58442  1.000 55.97611 ? 231 ASN A CA  1 
ATOM   1748 C C   . ASN A 1 231 ? -9.87147  -32.64185 -3.09607  1.000 54.90726 ? 231 ASN A C   1 
ATOM   1749 O O   . ASN A 1 231 ? -9.69697  -31.58782 -3.71138  1.000 55.98781 ? 231 ASN A O   1 
ATOM   1750 C CB  . ASN A 1 231 ? -8.66398  -32.41509 -0.93933  1.000 47.69049 ? 231 ASN A CB  1 
ATOM   1751 C CG  . ASN A 1 231 ? -8.76281  -31.81893 0.44599   1.000 55.18490 ? 231 ASN A CG  1 
ATOM   1752 O OD1 . ASN A 1 231 ? -9.47723  -30.83792 0.66031   1.000 55.47006 ? 231 ASN A OD1 1 
ATOM   1753 N ND2 . ASN A 1 231 ? -8.06224  -32.41785 1.40203   1.000 54.85569 ? 231 ASN A ND2 1 
ATOM   1754 N N   . LEU A 1 232 ? -9.92130  -33.81747 -3.71950  1.000 54.53117 ? 232 LEU A N   1 
ATOM   1755 C CA  . LEU A 1 232 ? -9.84448  -33.84388 -5.17678  1.000 54.32793 ? 232 LEU A CA  1 
ATOM   1756 C C   . LEU A 1 232 ? -11.11854 -33.28434 -5.79322  1.000 58.18270 ? 232 LEU A C   1 
ATOM   1757 O O   . LEU A 1 232 ? -11.06414 -32.54756 -6.78730  1.000 58.07317 ? 232 LEU A O   1 
ATOM   1758 C CB  . LEU A 1 232 ? -9.56795  -35.26624 -5.67125  1.000 55.29422 ? 232 LEU A CB  1 
ATOM   1759 C CG  . LEU A 1 232 ? -8.11398  -35.73083 -5.51812  1.000 58.24909 ? 232 LEU A CG  1 
ATOM   1760 C CD1 . LEU A 1 232 ? -8.01921  -37.24585 -5.62550  1.000 61.33814 ? 232 LEU A CD1 1 
ATOM   1761 C CD2 . LEU A 1 232 ? -7.19661  -35.05897 -6.54564  1.000 52.24688 ? 232 LEU A CD2 1 
ATOM   1762 N N   . VAL A 1 233 ? -12.27541 -33.60126 -5.19972  1.000 54.42647 ? 233 VAL A N   1 
ATOM   1763 C CA  . VAL A 1 233 ? -13.52571 -33.00531 -5.66184  1.000 56.43646 ? 233 VAL A CA  1 
ATOM   1764 C C   . VAL A 1 233 ? -13.57089 -31.51766 -5.32093  1.000 53.88941 ? 233 VAL A C   1 
ATOM   1765 O O   . VAL A 1 233 ? -14.07171 -30.70695 -6.10791  1.000 51.75343 ? 233 VAL A O   1 
ATOM   1766 C CB  . VAL A 1 233 ? -14.73259 -33.76631 -5.08051  1.000 54.32136 ? 233 VAL A CB  1 
ATOM   1767 C CG1 . VAL A 1 233 ? -16.03670 -33.11006 -5.52535  1.000 47.29037 ? 233 VAL A CG1 1 
ATOM   1768 C CG2 . VAL A 1 233 ? -14.68423 -35.22851 -5.51767  1.000 50.08314 ? 233 VAL A CG2 1 
ATOM   1769 N N   . ALA A 1 234 ? -13.04081 -31.13734 -4.15234  1.000 52.60344 ? 234 ALA A N   1 
ATOM   1770 C CA  . ALA A 1 234 ? -13.01063 -29.73049 -3.75875  1.000 55.55831 ? 234 ALA A CA  1 
ATOM   1771 C C   . ALA A 1 234 ? -12.29407 -28.87959 -4.79724  1.000 55.87834 ? 234 ALA A C   1 
ATOM   1772 O O   . ALA A 1 234 ? -12.84866 -27.89214 -5.29385  1.000 55.06070 ? 234 ALA A O   1 
ATOM   1773 C CB  . ALA A 1 234 ? -12.32763 -29.57792 -2.39973  1.000 54.62489 ? 234 ALA A CB  1 
ATOM   1774 N N   . MET A 1 235 ? -11.04552 -29.24139 -5.12316  1.000 54.91074 ? 235 MET A N   1 
ATOM   1775 C CA  . MET A 1 235 ? -10.27711 -28.48188 -6.09940  1.000 55.43391 ? 235 MET A CA  1 
ATOM   1776 C C   . MET A 1 235 ? -11.07878 -28.27204 -7.37398  1.000 55.33987 ? 235 MET A C   1 
ATOM   1777 O O   . MET A 1 235 ? -11.06103 -27.18372 -7.95644  1.000 56.11085 ? 235 MET A O   1 
ATOM   1778 C CB  . MET A 1 235 ? -8.95599  -29.19800 -6.39398  1.000 62.43046 ? 235 MET A CB  1 
ATOM   1779 N N   . LYS A 1 236 ? -11.82425 -29.29254 -7.80086  1.000 52.18274 ? 236 LYS A N   1 
ATOM   1780 C CA  . LYS A 1 236 ? -12.60382 -29.18328 -9.02839  1.000 51.32654 ? 236 LYS A CA  1 
ATOM   1781 C C   . LYS A 1 236 ? -13.72076 -28.14754 -8.92630  1.000 50.84902 ? 236 LYS A C   1 
ATOM   1782 O O   . LYS A 1 236 ? -14.14309 -27.60666 -9.95521  1.000 48.06431 ? 236 LYS A O   1 
ATOM   1783 C CB  . LYS A 1 236 ? -13.18929 -30.55344 -9.39809  1.000 54.83140 ? 236 LYS A CB  1 
ATOM   1784 C CG  . LYS A 1 236 ? -14.01812 -30.54415 -10.68014 1.000 54.64599 ? 236 LYS A CG  1 
ATOM   1785 C CD  . LYS A 1 236 ? -14.46803 -31.94551 -11.08730 1.000 59.62554 ? 236 LYS A CD  1 
ATOM   1786 C CE  . LYS A 1 236 ? -15.49736 -31.90235 -12.22292 1.000 60.90935 ? 236 LYS A CE  1 
ATOM   1787 N NZ  . LYS A 1 236 ? -16.37989 -33.12778 -12.22975 1.000 65.19528 ? 236 LYS A NZ  1 
ATOM   1788 N N   . TYR A 1 237 ? -14.21381 -27.86156 -7.71761  1.000 51.44873 ? 237 TYR A N   1 
ATOM   1789 C CA  . TYR A 1 237 ? -15.31959 -26.92574 -7.51531  1.000 51.36975 ? 237 TYR A CA  1 
ATOM   1790 C C   . TYR A 1 237 ? -14.86231 -25.61477 -6.88604  1.000 53.07080 ? 237 TYR A C   1 
ATOM   1791 O O   . TYR A 1 237 ? -15.68891 -24.84967 -6.37267  1.000 51.24497 ? 237 TYR A O   1 
ATOM   1792 C CB  . TYR A 1 237 ? -16.42812 -27.56726 -6.67625  1.000 49.46620 ? 237 TYR A CB  1 
ATOM   1793 C CG  . TYR A 1 237 ? -17.15584 -28.64216 -7.45097  1.000 51.12986 ? 237 TYR A CG  1 
ATOM   1794 C CD1 . TYR A 1 237 ? -18.21520 -28.32007 -8.29696  1.000 49.54810 ? 237 TYR A CD1 1 
ATOM   1795 C CD2 . TYR A 1 237 ? -16.74098 -29.97068 -7.39166  1.000 50.72027 ? 237 TYR A CD2 1 
ATOM   1796 C CE1 . TYR A 1 237 ? -18.86864 -29.30376 -9.03409  1.000 53.90655 ? 237 TYR A CE1 1 
ATOM   1797 C CE2 . TYR A 1 237 ? -17.38363 -30.95486 -8.13091  1.000 50.22487 ? 237 TYR A CE2 1 
ATOM   1798 C CZ  . TYR A 1 237 ? -18.44272 -30.61305 -8.95174  1.000 51.17983 ? 237 TYR A CZ  1 
ATOM   1799 O OH  . TYR A 1 237 ? -19.09272 -31.58148 -9.68188  1.000 54.58231 ? 237 TYR A OH  1 
ATOM   1800 N N   . ASN A 1 238 ? -13.56011 -25.34317 -6.92330  1.000 52.45015 ? 238 ASN A N   1 
ATOM   1801 C CA  . ASN A 1 238 ? -13.01682 -24.06696 -6.48413  1.000 51.88529 ? 238 ASN A CA  1 
ATOM   1802 C C   . ASN A 1 238 ? -13.22477 -23.86697 -4.98355  1.000 52.85742 ? 238 ASN A C   1 
ATOM   1803 O O   . ASN A 1 238 ? -13.48016 -22.75852 -4.50875  1.000 50.32863 ? 238 ASN A O   1 
ATOM   1804 C CB  . ASN A 1 238 ? -13.62107 -22.91910 -7.28591  1.000 50.43896 ? 238 ASN A CB  1 
ATOM   1805 C CG  . ASN A 1 238 ? -12.78677 -21.67173 -7.19521  1.000 61.44790 ? 238 ASN A CG  1 
ATOM   1806 O OD1 . ASN A 1 238 ? -11.66490 -21.70625 -6.67738  1.000 60.47675 ? 238 ASN A OD1 1 
ATOM   1807 N ND2 . ASN A 1 238 ? -13.32282 -20.55642 -7.68331  1.000 63.31196 ? 238 ASN A ND2 1 
ATOM   1808 N N   . TYR A 1 239 ? -13.12252 -24.95713 -4.23887  1.000 47.76785 ? 239 TYR A N   1 
ATOM   1809 C CA  . TYR A 1 239 ? -13.18945 -24.95895 -2.79264  1.000 45.46383 ? 239 TYR A CA  1 
ATOM   1810 C C   . TYR A 1 239 ? -11.77803 -25.09805 -2.24527  1.000 43.83256 ? 239 TYR A C   1 
ATOM   1811 O O   . TYR A 1 239 ? -10.95234 -25.82849 -2.79309  1.000 43.33337 ? 239 TYR A O   1 
ATOM   1812 C CB  . TYR A 1 239 ? -14.06417 -26.12464 -2.27794  1.000 40.53766 ? 239 TYR A CB  1 
ATOM   1813 C CG  . TYR A 1 239 ? -15.57512 -25.87498 -2.17345  1.000 37.18764 ? 239 TYR A CG  1 
ATOM   1814 C CD1 . TYR A 1 239 ? -16.31335 -25.45632 -3.26813  1.000 38.90333 ? 239 TYR A CD1 1 
ATOM   1815 C CD2 . TYR A 1 239 ? -16.26636 -26.11454 -0.97752  1.000 42.99757 ? 239 TYR A CD2 1 
ATOM   1816 C CE1 . TYR A 1 239 ? -17.69425 -25.24274 -3.18616  1.000 41.44286 ? 239 TYR A CE1 1 
ATOM   1817 C CE2 . TYR A 1 239 ? -17.65903 -25.90943 -0.88078  1.000 39.54218 ? 239 TYR A CE2 1 
ATOM   1818 C CZ  . TYR A 1 239 ? -18.36436 -25.47628 -1.99112  1.000 39.21490 ? 239 TYR A CZ  1 
ATOM   1819 O OH  . TYR A 1 239 ? -19.72460 -25.24733 -1.91756  1.000 45.47067 ? 239 TYR A OH  1 
ATOM   1820 N N   . GLU A 1 240 ? -11.52365 -24.42909 -1.13195  1.000 48.83415 ? 240 GLU A N   1 
ATOM   1821 C CA  . GLU A 1 240 ? -10.22037 -24.52189 -0.49648  1.000 50.89579 ? 240 GLU A CA  1 
ATOM   1822 C C   . GLU A 1 240 ? -9.95399  -25.95467 -0.04927  1.000 51.91670 ? 240 GLU A C   1 
ATOM   1823 O O   . GLU A 1 240 ? -10.87123 -26.64240 0.41121   1.000 50.49219 ? 240 GLU A O   1 
ATOM   1824 C CB  . GLU A 1 240 ? -10.14835 -23.58516 0.70763   1.000 51.13524 ? 240 GLU A CB  1 
ATOM   1825 C CG  . GLU A 1 240 ? -10.25362 -22.13499 0.32004   1.000 54.80010 ? 240 GLU A CG  1 
ATOM   1826 C CD  . GLU A 1 240 ? -9.07250  -21.33136 0.80728   1.000 65.14209 ? 240 GLU A CD  1 
ATOM   1827 O OE1 . GLU A 1 240 ? -8.92480  -21.22582 2.04510   1.000 74.73384 ? 240 GLU A OE1 1 
ATOM   1828 O OE2 . GLU A 1 240 ? -8.28690  -20.83294 -0.03939  1.000 62.29607 ? 240 GLU A OE2 1 
ATOM   1829 N N   . PRO A 1 241 ? -8.71655  -26.42969 -0.14344  1.000 54.97465 ? 241 PRO A N   1 
ATOM   1830 C CA  . PRO A 1 241 ? -8.39877  -27.74969 0.40980   1.000 51.31203 ? 241 PRO A CA  1 
ATOM   1831 C C   . PRO A 1 241 ? -8.75409  -27.80470 1.88931   1.000 49.16445 ? 241 PRO A C   1 
ATOM   1832 O O   . PRO A 1 241 ? -8.60098  -26.82276 2.61841   1.000 43.88498 ? 241 PRO A O   1 
ATOM   1833 C CB  . PRO A 1 241 ? -6.88477  -27.87375 0.17942   1.000 54.31252 ? 241 PRO A CB  1 
ATOM   1834 C CG  . PRO A 1 241 ? -6.56509  -26.84214 -0.86390  1.000 48.70890 ? 241 PRO A CG  1 
ATOM   1835 C CD  . PRO A 1 241 ? -7.51413  -25.72370 -0.61809  1.000 48.68444 ? 241 PRO A CD  1 
ATOM   1836 N N   . LEU A 1 242 ? -9.26297  -28.95684 2.33251   1.000 51.54049 ? 242 LEU A N   1 
ATOM   1837 C CA  . LEU A 1 242 ? -9.57856  -29.16234 3.73924   1.000 48.28002 ? 242 LEU A CA  1 
ATOM   1838 C C   . LEU A 1 242 ? -8.40097  -29.85215 4.41209   1.000 49.82742 ? 242 LEU A C   1 
ATOM   1839 O O   . LEU A 1 242 ? -7.91273  -30.87181 3.92039   1.000 53.18932 ? 242 LEU A O   1 
ATOM   1840 C CB  . LEU A 1 242 ? -10.85623 -29.99696 3.90855   1.000 50.89556 ? 242 LEU A CB  1 
ATOM   1841 C CG  . LEU A 1 242 ? -11.40588 -30.19295 5.32776   1.000 48.46218 ? 242 LEU A CG  1 
ATOM   1842 C CD1 . LEU A 1 242 ? -12.18680 -28.97443 5.80209   1.000 49.30933 ? 242 LEU A CD1 1 
ATOM   1843 C CD2 . LEU A 1 242 ? -12.29201 -31.46687 5.42248   1.000 50.19484 ? 242 LEU A CD2 1 
ATOM   1844 N N   . THR A 1 243 ? -7.96127  -29.31138 5.53939   1.000 54.00097 ? 243 THR A N   1 
ATOM   1845 C CA  . THR A 1 243 ? -6.79614  -29.82919 6.24119   1.000 56.71718 ? 243 THR A CA  1 
ATOM   1846 C C   . THR A 1 243 ? -7.22452  -30.62589 7.46231   1.000 56.51759 ? 243 THR A C   1 
ATOM   1847 O O   . THR A 1 243 ? -8.36730  -30.55012 7.91829   1.000 55.52929 ? 243 THR A O   1 
ATOM   1848 C CB  . THR A 1 243 ? -5.87548  -28.68955 6.67508   1.000 55.46235 ? 243 THR A CB  1 
ATOM   1849 O OG1 . THR A 1 243 ? -6.30184  -28.19797 7.95625   1.000 54.73498 ? 243 THR A OG1 1 
ATOM   1850 C CG2 . THR A 1 243 ? -5.92326  -27.56051 5.65272   1.000 56.35434 ? 243 THR A CG2 1 
ATOM   1851 N N   . GLN A 1 244 ? -6.27767  -31.38948 8.00982   1.000 57.32260 ? 244 GLN A N   1 
ATOM   1852 C CA  . GLN A 1 244 ? -6.57531  -32.10981 9.24201   1.000 57.87003 ? 244 GLN A CA  1 
ATOM   1853 C C   . GLN A 1 244 ? -6.89227  -31.14621 10.37410  1.000 56.44439 ? 244 GLN A C   1 
ATOM   1854 O O   . GLN A 1 244 ? -7.69283  -31.47144 11.26253  1.000 55.85192 ? 244 GLN A O   1 
ATOM   1855 C CB  . GLN A 1 244 ? -5.41363  -33.02452 9.63161   1.000 57.94979 ? 244 GLN A CB  1 
ATOM   1856 C CG  . GLN A 1 244 ? -5.64404  -33.76419 10.94826  1.000 55.81782 ? 244 GLN A CG  1 
ATOM   1857 C CD  . GLN A 1 244 ? -6.77987  -34.77426 10.86276  1.000 57.32840 ? 244 GLN A CD  1 
ATOM   1858 O OE1 . GLN A 1 244 ? -7.01009  -35.37655 9.80850   1.000 58.68741 ? 244 GLN A OE1 1 
ATOM   1859 N NE2 . GLN A 1 244 ? -7.49504  -34.96478 11.97347  1.000 53.41344 ? 244 GLN A NE2 1 
ATOM   1860 N N   . ASP A 1 245 ? -6.30144  -29.94658 10.34457  1.000 55.05111 ? 245 ASP A N   1 
ATOM   1861 C CA  . ASP A 1 245 ? -6.58977  -28.95809 11.37964  1.000 57.80354 ? 245 ASP A CA  1 
ATOM   1862 C C   . ASP A 1 245 ? -8.03907  -28.48695 11.29912  1.000 53.99045 ? 245 ASP A C   1 
ATOM   1863 O O   . ASP A 1 245 ? -8.67756  -28.25591 12.32896  1.000 55.39662 ? 245 ASP A O   1 
ATOM   1864 C CB  . ASP A 1 245 ? -5.62401  -27.77704 11.26409  1.000 60.69859 ? 245 ASP A CB  1 
ATOM   1865 C CG  . ASP A 1 245 ? -5.52387  -26.97659 12.55156  1.000 65.28864 ? 245 ASP A CG  1 
ATOM   1866 O OD1 . ASP A 1 245 ? -6.17842  -27.34882 13.55267  1.000 69.77807 ? 245 ASP A OD1 1 
ATOM   1867 O OD2 . ASP A 1 245 ? -4.78028  -25.97491 12.56754  1.000 76.98781 ? 245 ASP A OD2 1 
ATOM   1868 N N   . HIS A 1 246 ? -8.56505  -28.32619 10.08164  1.000 53.87047 ? 246 HIS A N   1 
ATOM   1869 C CA  . HIS A 1 246 ? -9.99446  -28.08589 9.89963   1.000 50.48885 ? 246 HIS A CA  1 
ATOM   1870 C C   . HIS A 1 246 ? -10.81920 -29.22897 10.49958  1.000 52.13049 ? 246 HIS A C   1 
ATOM   1871 O O   . HIS A 1 246 ? -11.75984 -28.99836 11.27346  1.000 45.46057 ? 246 HIS A O   1 
ATOM   1872 C CB  . HIS A 1 246 ? -10.29920 -27.91051 8.40320   1.000 46.65472 ? 246 HIS A CB  1 
ATOM   1873 C CG  . HIS A 1 246 ? -9.65322  -26.70152 7.77714   1.000 53.20832 ? 246 HIS A CG  1 
ATOM   1874 N ND1 . HIS A 1 246 ? -9.36905  -26.62027 6.42745   1.000 53.13337 ? 246 HIS A ND1 1 
ATOM   1875 C CD2 . HIS A 1 246 ? -9.25821  -25.51892 8.31241   1.000 51.20538 ? 246 HIS A CD2 1 
ATOM   1876 C CE1 . HIS A 1 246 ? -8.82080  -25.44501 6.16053   1.000 52.25958 ? 246 HIS A CE1 1 
ATOM   1877 N NE2 . HIS A 1 246 ? -8.74178  -24.75726 7.28719   1.000 46.79705 ? 246 HIS A NE2 1 
ATOM   1878 N N   . VAL A 1 247 ? -10.45924 -30.47543 10.17102  1.000 49.77718 ? 247 VAL A N   1 
ATOM   1879 C CA  . VAL A 1 247 ? -11.16790 -31.63552 10.71824  1.000 45.80008 ? 247 VAL A CA  1 
ATOM   1880 C C   . VAL A 1 247 ? -11.18240 -31.58651 12.24044  1.000 49.09065 ? 247 VAL A C   1 
ATOM   1881 O O   . VAL A 1 247 ? -12.22438 -31.78627 12.88218  1.000 50.96825 ? 247 VAL A O   1 
ATOM   1882 C CB  . VAL A 1 247 ? -10.54000 -32.94200 10.20336  1.000 46.70125 ? 247 VAL A CB  1 
ATOM   1883 C CG1 . VAL A 1 247 ? -11.20881 -34.16077 10.88898  1.000 42.04608 ? 247 VAL A CG1 1 
ATOM   1884 C CG2 . VAL A 1 247 ? -10.65901 -33.02851 8.69295   1.000 44.72869 ? 247 VAL A CG2 1 
ATOM   1885 N N   . ASP A 1 248 ? -10.02674 -31.31191 12.84479  1.000 51.28088 ? 248 ASP A N   1 
ATOM   1886 C CA  . ASP A 1 248 ? -9.96544  -31.25089 14.30314  1.000 53.47175 ? 248 ASP A CA  1 
ATOM   1887 C C   . ASP A 1 248 ? -10.88982 -30.16905 14.84736  1.000 53.60875 ? 248 ASP A C   1 
ATOM   1888 O O   . ASP A 1 248 ? -11.55957 -30.37009 15.86536  1.000 55.27934 ? 248 ASP A O   1 
ATOM   1889 C CB  . ASP A 1 248 ? -8.52799  -30.99514 14.76322  1.000 63.62413 ? 248 ASP A CB  1 
ATOM   1890 C CG  . ASP A 1 248 ? -7.52070  -31.91856 14.09730  1.000 62.23291 ? 248 ASP A CG  1 
ATOM   1891 O OD1 . ASP A 1 248 ? -7.77908  -33.13846 14.02130  1.000 60.30451 ? 248 ASP A OD1 1 
ATOM   1892 O OD2 . ASP A 1 248 ? -6.47134  -31.41128 13.63646  1.000 65.86230 ? 248 ASP A OD2 1 
ATOM   1893 N N   . ILE A 1 249 ? -10.92791 -29.00627 14.18558  1.000 52.51020 ? 249 ILE A N   1 
ATOM   1894 C CA  . ILE A 1 249 ? -11.76310 -27.90293 14.65513  1.000 51.82945 ? 249 ILE A CA  1 
ATOM   1895 C C   . ILE A 1 249 ? -13.23875 -28.25441 14.56104  1.000 45.99079 ? 249 ILE A C   1 
ATOM   1896 O O   . ILE A 1 249 ? -14.03967 -27.81330 15.39235  1.000 51.02799 ? 249 ILE A O   1 
ATOM   1897 C CB  . ILE A 1 249 ? -11.45896 -26.61808 13.86376  1.000 53.86641 ? 249 ILE A CB  1 
ATOM   1898 C CG1 . ILE A 1 249 ? -10.09561 -26.06221 14.26307  1.000 51.42337 ? 249 ILE A CG1 1 
ATOM   1899 C CG2 . ILE A 1 249 ? -12.56159 -25.58804 14.09781  1.000 51.13008 ? 249 ILE A CG2 1 
ATOM   1900 C CD1 . ILE A 1 249 ? -9.58113  -24.98832 13.31953  1.000 57.58708 ? 249 ILE A CD1 1 
ATOM   1901 N N   . LEU A 1 250 ? -13.62298 -29.02705 13.54559  1.000 48.25855 ? 250 LEU A N   1 
ATOM   1902 C CA  . LEU A 1 250 ? -14.98370 -29.52175 13.36795  1.000 47.83848 ? 250 LEU A CA  1 
ATOM   1903 C C   . LEU A 1 250 ? -15.33491 -30.66934 14.31586  1.000 52.21333 ? 250 LEU A C   1 
ATOM   1904 O O   . LEU A 1 250 ? -16.46893 -31.16498 14.27553  1.000 51.63447 ? 250 LEU A O   1 
ATOM   1905 C CB  . LEU A 1 250 ? -15.16821 -29.96342 11.91725  1.000 43.95776 ? 250 LEU A CB  1 
ATOM   1906 C CG  . LEU A 1 250 ? -15.28248 -28.88490 10.84815  1.000 43.89924 ? 250 LEU A CG  1 
ATOM   1907 C CD1 . LEU A 1 250 ? -15.30539 -29.50095 9.44097   1.000 42.62656 ? 250 LEU A CD1 1 
ATOM   1908 C CD2 . LEU A 1 250 ? -16.52447 -28.02128 11.10029  1.000 41.35444 ? 250 LEU A CD2 1 
ATOM   1909 N N   . GLY A 1 251 ? -14.40183 -31.09669 15.16534  1.000 54.63015 ? 251 GLY A N   1 
ATOM   1910 C CA  . GLY A 1 251 ? -14.63817 -32.17193 16.09492  1.000 49.28278 ? 251 GLY A CA  1 
ATOM   1911 C C   . GLY A 1 251 ? -15.87848 -31.97907 16.94782  1.000 54.11342 ? 251 GLY A C   1 
ATOM   1912 O O   . GLY A 1 251 ? -16.77914 -32.82416 16.96985  1.000 53.40248 ? 251 GLY A O   1 
ATOM   1913 N N   . PRO A 1 252 ? -15.94754 -30.87049 17.68680  1.000 51.82123 ? 252 PRO A N   1 
ATOM   1914 C CA  . PRO A 1 252 ? -17.06799 -30.71227 18.63325  1.000 53.43269 ? 252 PRO A CA  1 
ATOM   1915 C C   . PRO A 1 252 ? -18.43415 -30.75919 17.96581  1.000 54.96820 ? 252 PRO A C   1 
ATOM   1916 O O   . PRO A 1 252 ? -19.38074 -31.32446 18.53435  1.000 52.78390 ? 252 PRO A O   1 
ATOM   1917 C CB  . PRO A 1 252 ? -16.78977 -29.34601 19.27725  1.000 48.91584 ? 252 PRO A CB  1 
ATOM   1918 C CG  . PRO A 1 252 ? -15.32887 -29.14508 19.11074  1.000 51.07005 ? 252 PRO A CG  1 
ATOM   1919 C CD  . PRO A 1 252 ? -14.97106 -29.77439 17.79326  1.000 52.22021 ? 252 PRO A CD  1 
ATOM   1920 N N   . LEU A 1 253 ? -18.56025 -30.17544 16.76678  1.000 54.94878 ? 253 LEU A N   1 
ATOM   1921 C CA  . LEU A 1 253 ? -19.81695 -30.24726 16.02225  1.000 50.34621 ? 253 LEU A CA  1 
ATOM   1922 C C   . LEU A 1 253 ? -20.11043 -31.67738 15.58714  1.000 51.35597 ? 253 LEU A C   1 
ATOM   1923 O O   . LEU A 1 253 ? -21.24424 -32.15688 15.70852  1.000 51.73684 ? 253 LEU A O   1 
ATOM   1924 C CB  . LEU A 1 253 ? -19.76604 -29.31595 14.80808  1.000 45.42785 ? 253 LEU A CB  1 
ATOM   1925 C CG  . LEU A 1 253 ? -19.94610 -27.82430 15.10183  1.000 48.84579 ? 253 LEU A CG  1 
ATOM   1926 C CD1 . LEU A 1 253 ? -19.78160 -26.99205 13.82775  1.000 44.64956 ? 253 LEU A CD1 1 
ATOM   1927 C CD2 . LEU A 1 253 ? -21.30784 -27.58040 15.74618  1.000 44.25211 ? 253 LEU A CD2 1 
ATOM   1928 N N   . SER A 1 254 ? -19.09985 -32.36058 15.05192  1.000 47.63700 ? 254 SER A N   1 
ATOM   1929 C CA  . SER A 1 254 ? -19.21305 -33.78172 14.75782  1.000 52.57565 ? 254 SER A CA  1 
ATOM   1930 C C   . SER A 1 254 ? -19.73849 -34.55590 15.96270  1.000 53.64931 ? 254 SER A C   1 
ATOM   1931 O O   . SER A 1 254 ? -20.61216 -35.41938 15.82875  1.000 49.51366 ? 254 SER A O   1 
ATOM   1932 C CB  . SER A 1 254 ? -17.84430 -34.31245 14.32856  1.000 51.24787 ? 254 SER A CB  1 
ATOM   1933 O OG  . SER A 1 254 ? -17.91061 -35.66051 13.90307  1.000 47.14245 ? 254 SER A OG  1 
ATOM   1934 N N   . ALA A 1 255 ? -19.22287 -34.24113 17.15126  1.000 54.32501 ? 255 ALA A N   1 
ATOM   1935 C CA  . ALA A 1 255 ? -19.59990 -34.96047 18.35703  1.000 53.31891 ? 255 ALA A CA  1 
ATOM   1936 C C   . ALA A 1 255 ? -21.04657 -34.68923 18.73372  1.000 55.53244 ? 255 ALA A C   1 
ATOM   1937 O O   . ALA A 1 255 ? -21.77305 -35.60002 19.14623  1.000 54.28849 ? 255 ALA A O   1 
ATOM   1938 C CB  . ALA A 1 255 ? -18.66747 -34.55612 19.49702  1.000 54.77757 ? 255 ALA A CB  1 
ATOM   1939 N N   . GLN A 1 256 ? -21.48169 -33.43907 18.61805  1.000 58.71700 ? 256 GLN A N   1 
ATOM   1940 C CA  . GLN A 1 256 ? -22.83966 -33.11648 19.03200  1.000 52.80467 ? 256 GLN A CA  1 
ATOM   1941 C C   . GLN A 1 256 ? -23.86996 -33.72931 18.09640  1.000 53.18349 ? 256 GLN A C   1 
ATOM   1942 O O   . GLN A 1 256 ? -24.99897 -34.00198 18.52036  1.000 52.10014 ? 256 GLN A O   1 
ATOM   1943 C CB  . GLN A 1 256 ? -23.02417 -31.60250 19.11338  1.000 51.85434 ? 256 GLN A CB  1 
ATOM   1944 C CG  . GLN A 1 256 ? -24.38926 -31.17896 19.60140  1.000 53.62418 ? 256 GLN A CG  1 
ATOM   1945 C CD  . GLN A 1 256 ? -24.66986 -29.72654 19.27919  1.000 58.27869 ? 256 GLN A CD  1 
ATOM   1946 O OE1 . GLN A 1 256 ? -23.77509 -28.99808 18.83939  1.000 59.17602 ? 256 GLN A OE1 1 
ATOM   1947 N NE2 . GLN A 1 256 ? -25.91535 -29.29646 19.48136  1.000 56.11284 ? 256 GLN A NE2 1 
ATOM   1948 N N   . THR A 1 257 ? -23.51225 -33.95943 16.83208  1.000 47.21096 ? 257 THR A N   1 
ATOM   1949 C CA  . THR A 1 257 ? -24.46053 -34.52393 15.87848  1.000 50.22604 ? 257 THR A CA  1 
ATOM   1950 C C   . THR A 1 257 ? -24.28166 -36.01700 15.63888  1.000 48.37365 ? 257 THR A C   1 
ATOM   1951 O O   . THR A 1 257 ? -25.11848 -36.61523 14.96392  1.000 46.11769 ? 257 THR A O   1 
ATOM   1952 C CB  . THR A 1 257 ? -24.35451 -33.81330 14.52639  1.000 43.71543 ? 257 THR A CB  1 
ATOM   1953 O OG1 . THR A 1 257 ? -23.03125 -33.97893 14.00596  1.000 45.26545 ? 257 THR A OG1 1 
ATOM   1954 C CG2 . THR A 1 257 ? -24.68361 -32.33835 14.67929  1.000 45.11182 ? 257 THR A CG2 1 
ATOM   1955 N N   . GLY A 1 258 ? -23.20361 -36.61743 16.13121  1.000 49.88211 ? 258 GLY A N   1 
ATOM   1956 C CA  . GLY A 1 258 ? -22.90297 -37.99160 15.78719  1.000 51.24029 ? 258 GLY A CA  1 
ATOM   1957 C C   . GLY A 1 258 ? -22.55903 -38.23675 14.33476  1.000 52.05068 ? 258 GLY A C   1 
ATOM   1958 O O   . GLY A 1 258 ? -22.59298 -39.38616 13.88934  1.000 50.83200 ? 258 GLY A O   1 
ATOM   1959 N N   . ILE A 1 259 ? -22.21055 -37.20385 13.57202  1.000 46.08927 ? 259 ILE A N   1 
ATOM   1960 C CA  . ILE A 1 259 ? -21.82763 -37.38300 12.17538  1.000 48.25550 ? 259 ILE A CA  1 
ATOM   1961 C C   . ILE A 1 259 ? -20.33298 -37.11879 12.04681  1.000 51.17987 ? 259 ILE A C   1 
ATOM   1962 O O   . ILE A 1 259 ? -19.86649 -35.99363 12.28612  1.000 48.66351 ? 259 ILE A O   1 
ATOM   1963 C CB  . ILE A 1 259 ? -22.62720 -36.47146 11.23442  1.000 49.20536 ? 259 ILE A CB  1 
ATOM   1964 C CG1 . ILE A 1 259 ? -24.12206 -36.78788 11.33365  1.000 50.88468 ? 259 ILE A CG1 1 
ATOM   1965 C CG2 . ILE A 1 259 ? -22.09482 -36.59294 9.79355   1.000 41.98850 ? 259 ILE A CG2 1 
ATOM   1966 C CD1 . ILE A 1 259 ? -24.98895 -35.78204 10.60767  1.000 48.58370 ? 259 ILE A CD1 1 
ATOM   1967 N N   . ALA A 1 260 ? -19.58882 -38.15009 11.64454  1.000 47.75877 ? 260 ALA A N   1 
ATOM   1968 C CA  . ALA A 1 260 ? -18.15831 -37.99483 11.41385  1.000 49.92844 ? 260 ALA A CA  1 
ATOM   1969 C C   . ALA A 1 260 ? -17.89274 -36.89908 10.38674  1.000 46.06138 ? 260 ALA A C   1 
ATOM   1970 O O   . ALA A 1 260 ? -18.62517 -36.74871 9.40312   1.000 47.85760 ? 260 ALA A O   1 
ATOM   1971 C CB  . ALA A 1 260 ? -17.54642 -39.31373 10.93514  1.000 41.76273 ? 260 ALA A CB  1 
ATOM   1972 N N   . VAL A 1 261 ? -16.80717 -36.15492 10.59965  1.000 45.69243 ? 261 VAL A N   1 
ATOM   1973 C CA  . VAL A 1 261 ? -16.40934 -35.12089 9.64244   1.000 42.14206 ? 261 VAL A CA  1 
ATOM   1974 C C   . VAL A 1 261 ? -16.35752 -35.69666 8.22804   1.000 45.86493 ? 261 VAL A C   1 
ATOM   1975 O O   . VAL A 1 261 ? -16.99061 -35.18342 7.29174   1.000 42.71265 ? 261 VAL A O   1 
ATOM   1976 C CB  . VAL A 1 261 ? -15.05952 -34.50686 10.05603  1.000 41.73424 ? 261 VAL A CB  1 
ATOM   1977 C CG1 . VAL A 1 261 ? -14.59572 -33.46792 9.02720   1.000 42.40083 ? 261 VAL A CG1 1 
ATOM   1978 C CG2 . VAL A 1 261 ? -15.16060 -33.90783 11.42758  1.000 42.83948 ? 261 VAL A CG2 1 
ATOM   1979 N N   . LEU A 1 262 ? -15.60820 -36.78899 8.05344   1.000 42.73296 ? 262 LEU A N   1 
ATOM   1980 C CA  . LEU A 1 262 ? -15.44460 -37.34790 6.71478   1.000 45.35108 ? 262 LEU A CA  1 
ATOM   1981 C C   . LEU A 1 262 ? -16.77389 -37.81355 6.12779   1.000 46.00766 ? 262 LEU A C   1 
ATOM   1982 O O   . LEU A 1 262 ? -16.93926 -37.81528 4.90041   1.000 48.23114 ? 262 LEU A O   1 
ATOM   1983 C CB  . LEU A 1 262 ? -14.41387 -38.48786 6.73888   1.000 48.27537 ? 262 LEU A CB  1 
ATOM   1984 C CG  . LEU A 1 262 ? -12.93927 -38.08715 6.93622   1.000 51.86466 ? 262 LEU A CG  1 
ATOM   1985 C CD1 . LEU A 1 262 ? -11.99098 -39.26642 6.77044   1.000 51.83804 ? 262 LEU A CD1 1 
ATOM   1986 C CD2 . LEU A 1 262 ? -12.56129 -36.97797 5.98125   1.000 44.92978 ? 262 LEU A CD2 1 
ATOM   1987 N N   . ASP A 1 263 ? -17.73603 -38.19869 6.97922   1.000 46.48195 ? 263 ASP A N   1 
ATOM   1988 C CA  . ASP A 1 263 ? -19.06909 -38.51478 6.47861   1.000 45.54250 ? 263 ASP A CA  1 
ATOM   1989 C C   . ASP A 1 263 ? -19.79000 -37.25963 5.99711   1.000 43.05973 ? 263 ASP A C   1 
ATOM   1990 O O   . ASP A 1 263 ? -20.39476 -37.26002 4.91483   1.000 45.76742 ? 263 ASP A O   1 
ATOM   1991 C CB  . ASP A 1 263 ? -19.89054 -39.23252 7.55259   1.000 47.88077 ? 263 ASP A CB  1 
ATOM   1992 C CG  . ASP A 1 263 ? -19.38401 -40.64984 7.85045   1.000 50.54897 ? 263 ASP A CG  1 
ATOM   1993 O OD1 . ASP A 1 263 ? -18.65790 -41.22637 7.01914   1.000 54.55957 ? 263 ASP A OD1 1 
ATOM   1994 O OD2 . ASP A 1 263 ? -19.71799 -41.18797 8.92678   1.000 50.49436 ? 263 ASP A OD2 1 
ATOM   1995 N N   . MET A 1 264 ? -19.73415 -36.17120 6.77002   1.000 43.96377 ? 264 MET A N   1 
ATOM   1996 C CA  . MET A 1 264 ? -20.26459 -34.90855 6.24576   1.000 45.98860 ? 264 MET A CA  1 
ATOM   1997 C C   . MET A 1 264 ? -19.54922 -34.46920 4.96949   1.000 43.15426 ? 264 MET A C   1 
ATOM   1998 O O   . MET A 1 264 ? -20.16468 -33.84601 4.08659   1.000 40.19860 ? 264 MET A O   1 
ATOM   1999 C CB  . MET A 1 264 ? -20.17703 -33.79946 7.28773   1.000 41.73749 ? 264 MET A CB  1 
ATOM   2000 C CG  . MET A 1 264 ? -20.95335 -32.56494 6.82748   1.000 45.33448 ? 264 MET A CG  1 
ATOM   2001 S SD  . MET A 1 264 ? -22.73628 -32.87024 6.92532   1.000 41.06046 ? 264 MET A SD  1 
ATOM   2002 C CE  . MET A 1 264 ? -22.98924 -32.42599 8.64111   1.000 39.91431 ? 264 MET A CE  1 
ATOM   2003 N N   . CYS A 1 265 ? -18.25516 -34.78699 4.84402   1.000 41.24115 ? 265 CYS A N   1 
ATOM   2004 C CA  . CYS A 1 265 ? -17.54910 -34.46114 3.61119   1.000 43.13841 ? 265 CYS A CA  1 
ATOM   2005 C C   . CYS A 1 265 ? -18.12889 -35.21323 2.42661   1.000 44.66366 ? 265 CYS A C   1 
ATOM   2006 O O   . CYS A 1 265 ? -18.18355 -34.67583 1.31133   1.000 40.15178 ? 265 CYS A O   1 
ATOM   2007 C CB  . CYS A 1 265 ? -16.05337 -34.76826 3.74234   1.000 49.73355 ? 265 CYS A CB  1 
ATOM   2008 S SG  . CYS A 1 265 ? -15.06526 -33.56427 4.65841   1.000 46.24019 ? 265 CYS A SG  1 
ATOM   2009 N N   . ALA A 1 266 ? -18.54291 -36.47787 2.63043   1.000 43.89621 ? 266 ALA A N   1 
ATOM   2010 C CA  . ALA A 1 266 ? -19.13940 -37.20357 1.51490   1.000 40.65866 ? 266 ALA A CA  1 
ATOM   2011 C C   . ALA A 1 266 ? -20.48772 -36.59424 1.16312   1.000 37.57189 ? 266 ALA A C   1 
ATOM   2012 O O   . ALA A 1 266 ? -20.87052 -36.52395 -0.00843  1.000 39.16793 ? 266 ALA A O   1 
ATOM   2013 C CB  . ALA A 1 266 ? -19.26972 -38.69346 1.84841   1.000 47.17938 ? 266 ALA A CB  1 
ATOM   2014 N N   . SER A 1 267 ? -21.22414 -36.14371 2.17193   1.000 41.78597 ? 267 SER A N   1 
ATOM   2015 C CA  . SER A 1 267 ? -22.44039 -35.39673 1.89879   1.000 40.78110 ? 267 SER A CA  1 
ATOM   2016 C C   . SER A 1 267 ? -22.12573 -34.16290 1.04962   1.000 44.30783 ? 267 SER A C   1 
ATOM   2017 O O   . SER A 1 267 ? -22.67114 -33.98182 -0.05129  1.000 42.45985 ? 267 SER A O   1 
ATOM   2018 C CB  . SER A 1 267 ? -23.10478 -35.03107 3.22280   1.000 38.24727 ? 267 SER A CB  1 
ATOM   2019 O OG  . SER A 1 267 ? -24.23122 -34.21751 2.99574   1.000 44.91738 ? 267 SER A OG  1 
ATOM   2020 N N   . LEU A 1 268 ? -21.20400 -33.31891 1.52323   1.000 43.22372 ? 268 LEU A N   1 
ATOM   2021 C CA  . LEU A 1 268 ? -20.80157 -32.16133 0.71379   1.000 40.32361 ? 268 LEU A CA  1 
ATOM   2022 C C   . LEU A 1 268 ? -20.39139 -32.59192 -0.69366  1.000 41.64084 ? 268 LEU A C   1 
ATOM   2023 O O   . LEU A 1 268 ? -20.84254 -32.00723 -1.69093  1.000 40.34369 ? 268 LEU A O   1 
ATOM   2024 C CB  . LEU A 1 268 ? -19.67843 -31.38369 1.40619   1.000 39.85383 ? 268 LEU A CB  1 
ATOM   2025 C CG  . LEU A 1 268 ? -19.04505 -30.13360 0.73532   1.000 35.94594 ? 268 LEU A CG  1 
ATOM   2026 C CD1 . LEU A 1 268 ? -20.10424 -29.20931 0.16680   1.000 32.36321 ? 268 LEU A CD1 1 
ATOM   2027 C CD2 . LEU A 1 268 ? -18.22625 -29.40421 1.75735   1.000 39.17881 ? 268 LEU A CD2 1 
ATOM   2028 N N   . LYS A 1 269 ? -19.55232 -33.63325 -0.80224  1.000 41.84467 ? 269 LYS A N   1 
ATOM   2029 C CA  . LYS A 1 269 ? -19.15931 -34.11044 -2.12908  1.000 43.22100 ? 269 LYS A CA  1 
ATOM   2030 C C   . LYS A 1 269 ? -20.38370 -34.38545 -2.99700  1.000 45.31160 ? 269 LYS A C   1 
ATOM   2031 O O   . LYS A 1 269 ? -20.43922 -33.97660 -4.16117  1.000 45.12101 ? 269 LYS A O   1 
ATOM   2032 C CB  . LYS A 1 269 ? -18.28789 -35.36728 -2.01799  1.000 45.07505 ? 269 LYS A CB  1 
ATOM   2033 C CG  . LYS A 1 269 ? -17.88743 -35.92558 -3.38606  1.000 50.88672 ? 269 LYS A CG  1 
ATOM   2034 C CD  . LYS A 1 269 ? -17.15556 -37.26992 -3.31998  1.000 52.97749 ? 269 LYS A CD  1 
ATOM   2035 C CE  . LYS A 1 269 ? -16.06622 -37.27715 -2.26080  1.000 54.10775 ? 269 LYS A CE  1 
ATOM   2036 N NZ  . LYS A 1 269 ? -15.47592 -38.63770 -2.07645  1.000 58.81985 ? 269 LYS A NZ  1 
ATOM   2037 N N   . GLU A 1 270 ? -21.39396 -35.08296 -2.44063  1.000 45.20050 ? 270 GLU A N   1 
ATOM   2038 C CA  . GLU A 1 270 ? -22.59447 -35.35150 -3.22834  1.000 45.34281 ? 270 GLU A CA  1 
ATOM   2039 C C   . GLU A 1 270 ? -23.34668 -34.06029 -3.54448  1.000 45.02206 ? 270 GLU A C   1 
ATOM   2040 O O   . GLU A 1 270 ? -23.86515 -33.88949 -4.65587  1.000 46.83855 ? 270 GLU A O   1 
ATOM   2041 C CB  . GLU A 1 270 ? -23.50480 -36.35323 -2.50276  1.000 44.45872 ? 270 GLU A CB  1 
ATOM   2042 C CG  . GLU A 1 270 ? -24.61702 -36.87290 -3.37062  1.000 51.46372 ? 270 GLU A CG  1 
ATOM   2043 C CD  . GLU A 1 270 ? -25.52964 -37.87084 -2.64059  1.000 54.29188 ? 270 GLU A CD  1 
ATOM   2044 O OE1 . GLU A 1 270 ? -25.13074 -38.39688 -1.57995  1.000 48.09142 ? 270 GLU A OE1 1 
ATOM   2045 O OE2 . GLU A 1 270 ? -26.64808 -38.11519 -3.13446  1.000 61.97216 ? 270 GLU A OE2 1 
ATOM   2046 N N   . LEU A 1 271 ? -23.41991 -33.13988 -2.58033  1.000 43.47847 ? 271 LEU A N   1 
ATOM   2047 C CA  . LEU A 1 271 ? -24.04444 -31.84220 -2.84278  1.000 47.27767 ? 271 LEU A CA  1 
ATOM   2048 C C   . LEU A 1 271 ? -23.34479 -31.09118 -3.97540  1.000 45.37240 ? 271 LEU A C   1 
ATOM   2049 O O   . LEU A 1 271 ? -24.00365 -30.52136 -4.85456  1.000 48.31702 ? 271 LEU A O   1 
ATOM   2050 C CB  . LEU A 1 271 ? -24.04579 -31.00804 -1.56930  1.000 46.17738 ? 271 LEU A CB  1 
ATOM   2051 C CG  . LEU A 1 271 ? -25.26014 -31.23538 -0.69020  1.000 46.34492 ? 271 LEU A CG  1 
ATOM   2052 C CD1 . LEU A 1 271 ? -25.01449 -30.75407 0.74178   1.000 43.28758 ? 271 LEU A CD1 1 
ATOM   2053 C CD2 . LEU A 1 271 ? -26.45315 -30.52712 -1.32065  1.000 49.01602 ? 271 LEU A CD2 1 
ATOM   2054 N N   . LEU A 1 272 ? -22.01405 -31.08452 -3.98425  1.000 45.24237 ? 272 LEU A N   1 
ATOM   2055 C CA  . LEU A 1 272 ? -21.31104 -30.39449 -5.06547  1.000 46.94470 ? 272 LEU A CA  1 
ATOM   2056 C C   . LEU A 1 272 ? -21.54498 -31.07939 -6.40370  1.000 51.86594 ? 272 LEU A C   1 
ATOM   2057 O O   . LEU A 1 272 ? -21.69766 -30.41276 -7.43503  1.000 53.96168 ? 272 LEU A O   1 
ATOM   2058 C CB  . LEU A 1 272 ? -19.81970 -30.32311 -4.76641  1.000 48.06096 ? 272 LEU A CB  1 
ATOM   2059 C CG  . LEU A 1 272 ? -19.50121 -29.41566 -3.58607  1.000 45.80427 ? 272 LEU A CG  1 
ATOM   2060 C CD1 . LEU A 1 272 ? -18.04547 -29.54400 -3.24668  1.000 44.52807 ? 272 LEU A CD1 1 
ATOM   2061 C CD2 . LEU A 1 272 ? -19.86625 -27.97876 -3.92769  1.000 39.64946 ? 272 LEU A CD2 1 
ATOM   2062 N N   . GLN A 1 273 ? -21.58211 -32.41444 -6.40577  1.000 53.26411 ? 273 GLN A N   1 
ATOM   2063 C CA  . GLN A 1 273 ? -21.69763 -33.14766 -7.65705  1.000 53.72258 ? 273 GLN A CA  1 
ATOM   2064 C C   . GLN A 1 273 ? -23.11200 -33.12111 -8.21464  1.000 56.69470 ? 273 GLN A C   1 
ATOM   2065 O O   . GLN A 1 273 ? -23.28598 -33.10857 -9.43885  1.000 57.64972 ? 273 GLN A O   1 
ATOM   2066 C CB  . GLN A 1 273 ? -21.21689 -34.58382 -7.45662  1.000 55.23982 ? 273 GLN A CB  1 
ATOM   2067 C CG  . GLN A 1 273 ? -19.70605 -34.67673 -7.34854  1.000 55.54851 ? 273 GLN A CG  1 
ATOM   2068 C CD  . GLN A 1 273 ? -19.23559 -36.02219 -6.84208  1.000 60.23124 ? 273 GLN A CD  1 
ATOM   2069 O OE1 . GLN A 1 273 ? -20.04056 -36.87789 -6.48504  1.000 62.00912 ? 273 GLN A OE1 1 
ATOM   2070 N NE2 . GLN A 1 273 ? -17.92216 -36.21182 -6.79861  1.000 63.62345 ? 273 GLN A NE2 1 
ATOM   2071 N N   . ASN A 1 274 ? -24.12695 -33.09030 -7.34742  1.000 57.72719 ? 274 ASN A N   1 
ATOM   2072 C CA  . ASN A 1 274 ? -25.51046 -33.14997 -7.79680  1.000 57.03934 ? 274 ASN A CA  1 
ATOM   2073 C C   . ASN A 1 274 ? -26.24626 -31.82099 -7.72205  1.000 57.70047 ? 274 ASN A C   1 
ATOM   2074 O O   . ASN A 1 274 ? -27.27753 -31.66894 -8.38534  1.000 61.04093 ? 274 ASN A O   1 
ATOM   2075 C CB  . ASN A 1 274 ? -26.28974 -34.18461 -6.97865  1.000 58.32357 ? 274 ASN A CB  1 
ATOM   2076 C CG  . ASN A 1 274 ? -25.69368 -35.57061 -7.07595  1.000 61.05188 ? 274 ASN A CG  1 
ATOM   2077 O OD1 . ASN A 1 274 ? -24.81195 -35.82341 -7.89529  1.000 62.19535 ? 274 ASN A OD1 1 
ATOM   2078 N ND2 . ASN A 1 274 ? -26.17612 -36.48384 -6.23436  1.000 63.67859 ? 274 ASN A ND2 1 
ATOM   2079 N N   . GLY A 1 275 ? -25.75225 -30.85798 -6.95587  1.000 58.21967 ? 275 GLY A N   1 
ATOM   2080 C CA  . GLY A 1 275 ? -26.56720 -29.69728 -6.67232  1.000 58.51879 ? 275 GLY A CA  1 
ATOM   2081 C C   . GLY A 1 275 ? -27.60137 -30.03921 -5.61226  1.000 59.05855 ? 275 GLY A C   1 
ATOM   2082 O O   . GLY A 1 275 ? -27.47751 -31.02648 -4.88024  1.000 53.85056 ? 275 GLY A O   1 
ATOM   2083 N N   . MET A 1 276 ? -28.64409 -29.21404 -5.53525  1.000 58.09786 ? 276 MET A N   1 
ATOM   2084 C CA  . MET A 1 276 ? -29.63577 -29.37631 -4.48773  1.000 59.91304 ? 276 MET A CA  1 
ATOM   2085 C C   . MET A 1 276 ? -31.00590 -29.82638 -4.98126  1.000 63.09470 ? 276 MET A C   1 
ATOM   2086 O O   . MET A 1 276 ? -31.84928 -30.18311 -4.14999  1.000 64.08591 ? 276 MET A O   1 
ATOM   2087 C CB  . MET A 1 276 ? -29.76212 -28.07457 -3.68093  1.000 57.01432 ? 276 MET A CB  1 
ATOM   2088 C CG  . MET A 1 276 ? -28.61076 -27.92019 -2.68552  1.000 59.65837 ? 276 MET A CG  1 
ATOM   2089 S SD  . MET A 1 276 ? -28.50742 -26.35241 -1.81191  1.000 62.40553 ? 276 MET A SD  1 
ATOM   2090 C CE  . MET A 1 276 ? -29.98657 -26.41982 -0.82855  1.000 49.82740 ? 276 MET A CE  1 
ATOM   2091 N N   . ASN A 1 277 ? -31.24398 -29.85986 -6.29417  1.000 63.50983 ? 277 ASN A N   1 
ATOM   2092 C CA  . ASN A 1 277 ? -32.51637 -30.33888 -6.84862  1.000 66.53894 ? 277 ASN A CA  1 
ATOM   2093 C C   . ASN A 1 277 ? -33.69855 -29.55839 -6.27623  1.000 62.26866 ? 277 ASN A C   1 
ATOM   2094 O O   . ASN A 1 277 ? -34.68382 -30.13215 -5.80420  1.000 63.47743 ? 277 ASN A O   1 
ATOM   2095 C CB  . ASN A 1 277 ? -32.69795 -31.84404 -6.61509  1.000 67.34060 ? 277 ASN A CB  1 
ATOM   2096 N N   . GLY A 1 278 ? -33.59572 -28.23299 -6.32638  1.000 62.31723 ? 278 GLY A N   1 
ATOM   2097 C CA  . GLY A 1 278 ? -34.68136 -27.37539 -5.90282  1.000 61.46637 ? 278 GLY A CA  1 
ATOM   2098 C C   . GLY A 1 278 ? -34.89646 -27.27808 -4.40996  1.000 62.78871 ? 278 GLY A C   1 
ATOM   2099 O O   . GLY A 1 278 ? -35.75981 -26.50594 -3.97901  1.000 67.27536 ? 278 GLY A O   1 
ATOM   2100 N N   . ARG A 1 279 ? -34.15645 -28.03285 -3.60696  1.000 61.76951 ? 279 ARG A N   1 
ATOM   2101 C CA  . ARG A 1 279 ? -34.28135 -27.96338 -2.16071  1.000 56.27692 ? 279 ARG A CA  1 
ATOM   2102 C C   . ARG A 1 279 ? -33.38903 -26.85051 -1.60895  1.000 54.56531 ? 279 ARG A C   1 
ATOM   2103 O O   . ARG A 1 279 ? -32.56613 -26.25695 -2.31609  1.000 54.34545 ? 279 ARG A O   1 
ATOM   2104 C CB  . ARG A 1 279 ? -33.92513 -29.31096 -1.52137  1.000 54.29142 ? 279 ARG A CB  1 
ATOM   2105 C CG  . ARG A 1 279 ? -34.81409 -30.48402 -1.96604  1.000 60.85799 ? 279 ARG A CG  1 
ATOM   2106 C CD  . ARG A 1 279 ? -34.33950 -31.82406 -1.40317  1.000 52.22002 ? 279 ARG A CD  1 
ATOM   2107 N N   . THR A 1 280 ? -33.56952 -26.56098 -0.32402  1.000 49.55393 ? 280 THR A N   1 
ATOM   2108 C CA  . THR A 1 280 ? -32.79374 -25.53579 0.35568   1.000 48.22259 ? 280 THR A CA  1 
ATOM   2109 C C   . THR A 1 280 ? -32.24589 -26.10479 1.65247   1.000 47.94491 ? 280 THR A C   1 
ATOM   2110 O O   . THR A 1 280 ? -32.72020 -27.13374 2.15737   1.000 41.81965 ? 280 THR A O   1 
ATOM   2111 C CB  . THR A 1 280 ? -33.63572 -24.29118 0.64243   1.000 46.70753 ? 280 THR A CB  1 
ATOM   2112 O OG1 . THR A 1 280 ? -34.79071 -24.66730 1.40896   1.000 52.11126 ? 280 THR A OG1 1 
ATOM   2113 C CG2 . THR A 1 280 ? -34.07972 -23.65503 -0.66578  1.000 47.51794 ? 280 THR A CG2 1 
ATOM   2114 N N   . ILE A 1 281 ? -31.22193 -25.42734 2.16633   1.000 38.64477 ? 281 ILE A N   1 
ATOM   2115 C CA  . ILE A 1 281 ? -30.61954 -25.73124 3.45724   1.000 36.11310 ? 281 ILE A CA  1 
ATOM   2116 C C   . ILE A 1 281 ? -30.58500 -24.45090 4.27475   1.000 41.40443 ? 281 ILE A C   1 
ATOM   2117 O O   . ILE A 1 281 ? -29.98125 -23.45006 3.85184   1.000 41.88824 ? 281 ILE A O   1 
ATOM   2118 C CB  . ILE A 1 281 ? -29.20506 -26.31004 3.32007   1.000 34.71377 ? 281 ILE A CB  1 
ATOM   2119 C CG1 . ILE A 1 281 ? -29.22301 -27.62373 2.53882   1.000 44.42268 ? 281 ILE A CG1 1 
ATOM   2120 C CG2 . ILE A 1 281 ? -28.59368 -26.47359 4.68055   1.000 37.95715 ? 281 ILE A CG2 1 
ATOM   2121 C CD1 . ILE A 1 281 ? -27.82912 -28.17616 2.24744   1.000 42.28213 ? 281 ILE A CD1 1 
ATOM   2122 N N   . LEU A 1 282 ? -31.19697 -24.48902 5.45884   1.000 39.64535 ? 282 LEU A N   1 
ATOM   2123 C CA  . LEU A 1 282 ? -31.33035 -23.29464 6.29181   1.000 39.47314 ? 282 LEU A CA  1 
ATOM   2124 C C   . LEU A 1 282 ? -31.78147 -22.09973 5.45488   1.000 44.07101 ? 282 LEU A C   1 
ATOM   2125 O O   . LEU A 1 282 ? -31.25642 -20.99248 5.57205   1.000 42.18622 ? 282 LEU A O   1 
ATOM   2126 C CB  . LEU A 1 282 ? -30.02481 -22.99131 7.02000   1.000 40.59506 ? 282 LEU A CB  1 
ATOM   2127 C CG  . LEU A 1 282 ? -29.70048 -24.05453 8.06713   1.000 45.28551 ? 282 LEU A CG  1 
ATOM   2128 C CD1 . LEU A 1 282 ? -28.29182 -23.92605 8.57214   1.000 39.72054 ? 282 LEU A CD1 1 
ATOM   2129 C CD2 . LEU A 1 282 ? -30.67625 -23.97813 9.21295   1.000 40.95995 ? 282 LEU A CD2 1 
ATOM   2130 N N   . GLY A 1 283 ? -32.73768 -22.33990 4.56412   1.000 46.94876 ? 283 GLY A N   1 
ATOM   2131 C CA  . GLY A 1 283 ? -33.31953 -21.26046 3.79074   1.000 46.39903 ? 283 GLY A CA  1 
ATOM   2132 C C   . GLY A 1 283 ? -32.46577 -20.72642 2.66792   1.000 47.01865 ? 283 GLY A C   1 
ATOM   2133 O O   . GLY A 1 283 ? -32.79034 -19.67579 2.10230   1.000 49.14548 ? 283 GLY A O   1 
ATOM   2134 N N   . SER A 1 284 ? -31.37396 -21.38951 2.33498   1.000 43.77168 ? 284 SER A N   1 
ATOM   2135 C CA  . SER A 1 284 ? -30.52947 -20.94637 1.24108   1.000 44.13383 ? 284 SER A CA  1 
ATOM   2136 C C   . SER A 1 284 ? -30.51464 -22.00583 0.15153   1.000 46.83063 ? 284 SER A C   1 
ATOM   2137 O O   . SER A 1 284 ? -30.49254 -23.20740 0.44046   1.000 41.82187 ? 284 SER A O   1 
ATOM   2138 C CB  . SER A 1 284 ? -29.10697 -20.65336 1.71277   1.000 40.74713 ? 284 SER A CB  1 
ATOM   2139 O OG  . SER A 1 284 ? -28.26924 -20.45411 0.57821   1.000 46.70019 ? 284 SER A OG  1 
ATOM   2140 N N   . ALA A 1 285 ? -30.53653 -21.55302 -1.10016  1.000 40.21752 ? 285 ALA A N   1 
ATOM   2141 C CA  . ALA A 1 285 ? -30.35918 -22.43661 -2.24244  1.000 44.39500 ? 285 ALA A CA  1 
ATOM   2142 C C   . ALA A 1 285 ? -28.89559 -22.58241 -2.64425  1.000 48.84550 ? 285 ALA A C   1 
ATOM   2143 O O   . ALA A 1 285 ? -28.60310 -23.25950 -3.63671  1.000 50.39508 ? 285 ALA A O   1 
ATOM   2144 C CB  . ALA A 1 285 ? -31.17631 -21.93375 -3.43713  1.000 46.17161 ? 285 ALA A CB  1 
ATOM   2145 N N   . LEU A 1 286 ? -27.98039 -21.96820 -1.89639  1.000 43.85533 ? 286 LEU A N   1 
ATOM   2146 C CA  . LEU A 1 286 ? -26.54440 -22.05590 -2.11756  1.000 45.96008 ? 286 LEU A CA  1 
ATOM   2147 C C   . LEU A 1 286 ? -25.88026 -22.60612 -0.86273  1.000 43.88955 ? 286 LEU A C   1 
ATOM   2148 O O   . LEU A 1 286 ? -26.42187 -22.51437 0.23885   1.000 46.17184 ? 286 LEU A O   1 
ATOM   2149 C CB  . LEU A 1 286 ? -25.93719 -20.67788 -2.45662  1.000 44.04376 ? 286 LEU A CB  1 
ATOM   2150 C CG  . LEU A 1 286 ? -26.42232 -20.02770 -3.74756  1.000 49.35356 ? 286 LEU A CG  1 
ATOM   2151 C CD1 . LEU A 1 286 ? -25.83023 -18.63316 -3.93910  1.000 48.80628 ? 286 LEU A CD1 1 
ATOM   2152 C CD2 . LEU A 1 286 ? -26.08808 -20.92495 -4.93089  1.000 54.35262 ? 286 LEU A CD2 1 
ATOM   2153 N N   . LEU A 1 287 ? -24.69383 -23.17994 -1.02844  1.000 44.36484 ? 287 LEU A N   1 
ATOM   2154 C CA  . LEU A 1 287 ? -23.91540 -23.60944 0.12477   1.000 38.09478 ? 287 LEU A CA  1 
ATOM   2155 C C   . LEU A 1 287 ? -23.22633 -22.38792 0.73617   1.000 40.87023 ? 287 LEU A C   1 
ATOM   2156 O O   . LEU A 1 287 ? -22.42382 -21.71678 0.07779   1.000 40.17730 ? 287 LEU A O   1 
ATOM   2157 C CB  . LEU A 1 287 ? -22.91901 -24.68768 -0.29150  1.000 43.28019 ? 287 LEU A CB  1 
ATOM   2158 C CG  . LEU A 1 287 ? -23.55534 -25.91890 -0.95885  1.000 41.35547 ? 287 LEU A CG  1 
ATOM   2159 C CD1 . LEU A 1 287 ? -22.51685 -26.87468 -1.49123  1.000 43.93747 ? 287 LEU A CD1 1 
ATOM   2160 C CD2 . LEU A 1 287 ? -24.48426 -26.65043 0.00070   1.000 43.53712 ? 287 LEU A CD2 1 
ATOM   2161 N N   . GLU A 1 288 ? -23.55164 -22.10405 1.99105   1.000 43.92506 ? 288 GLU A N   1 
ATOM   2162 C CA  A GLU A 1 288 ? -23.11740 -20.88640 2.66224   0.500 40.48275 ? 288 GLU A CA  1 
ATOM   2163 C CA  B GLU A 1 288 ? -23.12615 -20.89138 2.67607   0.500 40.18151 ? 288 GLU A CA  1 
ATOM   2164 C C   . GLU A 1 288 ? -21.74737 -21.08417 3.29612   1.000 41.36544 ? 288 GLU A C   1 
ATOM   2165 O O   . GLU A 1 288 ? -21.53557 -22.02628 4.05502   1.000 37.83808 ? 288 GLU A O   1 
ATOM   2166 C CB  A GLU A 1 288 ? -24.13373 -20.48829 3.72896   0.500 38.20804 ? 288 GLU A CB  1 
ATOM   2167 C CB  B GLU A 1 288 ? -24.14578 -20.54070 3.75851   0.500 38.36289 ? 288 GLU A CB  1 
ATOM   2168 C CG  A GLU A 1 288 ? -25.49115 -20.11789 3.17416   0.500 39.64193 ? 288 GLU A CG  1 
ATOM   2169 C CG  B GLU A 1 288 ? -23.79191 -19.32417 4.57580   0.500 40.84519 ? 288 GLU A CG  1 
ATOM   2170 C CD  A GLU A 1 288 ? -25.51628 -18.70418 2.63272   0.500 42.94875 ? 288 GLU A CD  1 
ATOM   2171 C CD  B GLU A 1 288 ? -23.65202 -18.10106 3.70748   0.500 42.27012 ? 288 GLU A CD  1 
ATOM   2172 O OE1 A GLU A 1 288 ? -25.08333 -17.78705 3.36701   0.500 39.47402 ? 288 GLU A OE1 1 
ATOM   2173 O OE1 B GLU A 1 288 ? -24.44992 -17.97548 2.75068   0.500 42.16483 ? 288 GLU A OE1 1 
ATOM   2174 O OE2 A GLU A 1 288 ? -25.95643 -18.51915 1.47787   0.500 41.17706 ? 288 GLU A OE2 1 
ATOM   2175 O OE2 B GLU A 1 288 ? -22.73816 -17.29343 3.96423   0.500 37.15775 ? 288 GLU A OE2 1 
ATOM   2176 N N   . ASP A 1 289 ? -20.80729 -20.18194 3.00024   1.000 41.26936 ? 289 ASP A N   1 
ATOM   2177 C CA  . ASP A 1 289 ? -19.48295 -20.37420 3.57437   1.000 41.71238 ? 289 ASP A CA  1 
ATOM   2178 C C   . ASP A 1 289 ? -19.04851 -19.24197 4.50714   1.000 42.53082 ? 289 ASP A C   1 
ATOM   2179 O O   . ASP A 1 289 ? -17.86344 -19.15428 4.84635   1.000 42.68956 ? 289 ASP A O   1 
ATOM   2180 C CB  . ASP A 1 289 ? -18.45075 -20.59737 2.46773   1.000 39.80228 ? 289 ASP A CB  1 
ATOM   2181 C CG  . ASP A 1 289 ? -18.02545 -19.29493 1.76701   1.000 42.40296 ? 289 ASP A CG  1 
ATOM   2182 O OD1 . ASP A 1 289 ? -18.67621 -18.23960 1.93417   1.000 37.99453 ? 289 ASP A OD1 1 
ATOM   2183 O OD2 . ASP A 1 289 ? -17.05436 -19.36610 1.00397   1.000 38.02269 ? 289 ASP A OD2 1 
ATOM   2184 N N   . GLU A 1 290 ? -19.96717 -18.39586 4.97706   1.000 37.44119 ? 290 GLU A N   1 
ATOM   2185 C CA  . GLU A 1 290 ? -19.57441 -17.30274 5.86257   1.000 44.13981 ? 290 GLU A CA  1 
ATOM   2186 C C   . GLU A 1 290 ? -20.01934 -17.52460 7.30807   1.000 43.32672 ? 290 GLU A C   1 
ATOM   2187 O O   . GLU A 1 290 ? -20.28689 -16.56432 8.03631   1.000 43.23997 ? 290 GLU A O   1 
ATOM   2188 C CB  . GLU A 1 290 ? -20.06868 -15.95783 5.31822   1.000 43.72867 ? 290 GLU A CB  1 
ATOM   2189 C CG  . GLU A 1 290 ? -19.41962 -15.63307 3.96772   1.000 42.14450 ? 290 GLU A CG  1 
ATOM   2190 C CD  . GLU A 1 290 ? -19.04310 -14.16629 3.79277   1.000 47.94225 ? 290 GLU A CD  1 
ATOM   2191 O OE1 . GLU A 1 290 ? -19.64913 -13.29988 4.46626   1.000 44.08180 ? 290 GLU A OE1 1 
ATOM   2192 O OE2 . GLU A 1 290 ? -18.13664 -13.89506 2.96488   1.000 46.82671 ? 290 GLU A OE2 1 
ATOM   2193 N N   . PHE A 1 291 ? -20.07581 -18.78899 7.74041   1.000 38.24599 ? 291 PHE A N   1 
ATOM   2194 C CA  . PHE A 1 291 ? -20.19751 -19.15535 9.14574   1.000 36.79658 ? 291 PHE A CA  1 
ATOM   2195 C C   . PHE A 1 291 ? -19.00171 -20.02661 9.51453   1.000 41.38104 ? 291 PHE A C   1 
ATOM   2196 O O   . PHE A 1 291 ? -18.81044 -21.09400 8.91973   1.000 41.01152 ? 291 PHE A O   1 
ATOM   2197 C CB  . PHE A 1 291 ? -21.49757 -19.93689 9.43195   1.000 39.50426 ? 291 PHE A CB  1 
ATOM   2198 C CG  . PHE A 1 291 ? -22.76652 -19.14235 9.26283   1.000 40.14657 ? 291 PHE A CG  1 
ATOM   2199 C CD1 . PHE A 1 291 ? -23.28500 -18.39442 10.31358  1.000 37.70170 ? 291 PHE A CD1 1 
ATOM   2200 C CD2 . PHE A 1 291 ? -23.46812 -19.18490 8.07502   1.000 38.16546 ? 291 PHE A CD2 1 
ATOM   2201 C CE1 . PHE A 1 291 ? -24.46156 -17.68019 10.15964  1.000 43.51849 ? 291 PHE A CE1 1 
ATOM   2202 C CE2 . PHE A 1 291 ? -24.64706 -18.47173 7.92202   1.000 40.18179 ? 291 PHE A CE2 1 
ATOM   2203 C CZ  . PHE A 1 291 ? -25.14261 -17.72082 8.95943   1.000 36.52979 ? 291 PHE A CZ  1 
ATOM   2204 N N   . THR A 1 292 ? -18.21634 -19.60601 10.50517  1.000 39.62196 ? 292 THR A N   1 
ATOM   2205 C CA  . THR A 1 292 ? -17.18778 -20.49740 11.01741  1.000 39.35679 ? 292 THR A CA  1 
ATOM   2206 C C   . THR A 1 292 ? -17.81122 -21.57323 11.90818  1.000 41.17480 ? 292 THR A C   1 
ATOM   2207 O O   . THR A 1 292 ? -18.97593 -21.49595 12.29503  1.000 38.95583 ? 292 THR A O   1 
ATOM   2208 C CB  . THR A 1 292 ? -16.14395 -19.72229 11.80694  1.000 37.97799 ? 292 THR A CB  1 
ATOM   2209 O OG1 . THR A 1 292 ? -16.75625 -19.13722 12.95460  1.000 39.12149 ? 292 THR A OG1 1 
ATOM   2210 C CG2 . THR A 1 292 ? -15.47277 -18.61445 10.93345  1.000 40.62978 ? 292 THR A CG2 1 
ATOM   2211 N N   . PRO A 1 293 ? -17.02982 -22.58204 12.28288  1.000 44.56640 ? 293 PRO A N   1 
ATOM   2212 C CA  . PRO A 1 293 ? -17.50366 -23.52484 13.31140  1.000 40.32024 ? 293 PRO A CA  1 
ATOM   2213 C C   . PRO A 1 293 ? -17.83507 -22.83126 14.62529  1.000 45.17456 ? 293 PRO A C   1 
ATOM   2214 O O   . PRO A 1 293 ? -18.82704 -23.18212 15.28334  1.000 40.25384 ? 293 PRO A O   1 
ATOM   2215 C CB  . PRO A 1 293 ? -16.32487 -24.50416 13.44178  1.000 40.60186 ? 293 PRO A CB  1 
ATOM   2216 C CG  . PRO A 1 293 ? -15.67682 -24.49110 12.10397  1.000 43.68087 ? 293 PRO A CG  1 
ATOM   2217 C CD  . PRO A 1 293 ? -15.77229 -23.02420 11.65452  1.000 41.56608 ? 293 PRO A CD  1 
ATOM   2218 N N   . PHE A 1 294 ? -17.04649 -21.81382 15.00089  1.000 47.86359 ? 294 PHE A N   1 
ATOM   2219 C CA  . PHE A 1 294 ? -17.32599 -21.05470 16.21814  1.000 41.35505 ? 294 PHE A CA  1 
ATOM   2220 C C   . PHE A 1 294 ? -18.64897 -20.31692 16.11104  1.000 43.99692 ? 294 PHE A C   1 
ATOM   2221 O O   . PHE A 1 294 ? -19.44711 -20.33022 17.05841  1.000 48.65073 ? 294 PHE A O   1 
ATOM   2222 C CB  . PHE A 1 294 ? -16.18074 -20.08121 16.50658  1.000 51.13184 ? 294 PHE A CB  1 
ATOM   2223 C CG  . PHE A 1 294 ? -16.41575 -19.19999 17.71091  1.000 58.20087 ? 294 PHE A CG  1 
ATOM   2224 C CD1 . PHE A 1 294 ? -17.24771 -18.07776 17.62727  1.000 55.72737 ? 294 PHE A CD1 1 
ATOM   2225 C CD2 . PHE A 1 294 ? -15.79524 -19.47842 18.92106  1.000 57.69512 ? 294 PHE A CD2 1 
ATOM   2226 C CE1 . PHE A 1 294 ? -17.48024 -17.26982 18.73778  1.000 56.64105 ? 294 PHE A CE1 1 
ATOM   2227 C CE2 . PHE A 1 294 ? -16.01099 -18.66313 20.03579  1.000 60.98862 ? 294 PHE A CE2 1 
ATOM   2228 C CZ  . PHE A 1 294 ? -16.85452 -17.56079 19.94353  1.000 62.23636 ? 294 PHE A CZ  1 
ATOM   2229 N N   . ASP A 1 295 ? -18.91273 -19.68383 14.96091  1.000 38.59362 ? 295 ASP A N   1 
ATOM   2230 C CA  . ASP A 1 295 ? -20.20482 -19.03598 14.74502  1.000 36.68201 ? 295 ASP A CA  1 
ATOM   2231 C C   . ASP A 1 295 ? -21.36555 -19.99712 14.98010  1.000 44.85777 ? 295 ASP A C   1 
ATOM   2232 O O   . ASP A 1 295 ? -22.39335 -19.60034 15.53944  1.000 37.86175 ? 295 ASP A O   1 
ATOM   2233 C CB  . ASP A 1 295 ? -20.29615 -18.47727 13.33188  1.000 35.06696 ? 295 ASP A CB  1 
ATOM   2234 C CG  . ASP A 1 295 ? -19.30154 -17.32441 13.09674  1.000 39.91640 ? 295 ASP A CG  1 
ATOM   2235 O OD1 . ASP A 1 295 ? -18.85792 -16.72871 14.10254  1.000 38.77663 ? 295 ASP A OD1 1 
ATOM   2236 O OD2 . ASP A 1 295 ? -19.00156 -17.01762 11.92131  1.000 35.53421 ? 295 ASP A OD2 1 
ATOM   2237 N N   . VAL A 1 296 ? -21.24523 -21.24136 14.49710  1.000 43.36191 ? 296 VAL A N   1 
ATOM   2238 C CA  . VAL A 1 296 ? -22.34149 -22.20598 14.63322  1.000 43.02808 ? 296 VAL A CA  1 
ATOM   2239 C C   . VAL A 1 296 ? -22.55471 -22.57202 16.09575  1.000 41.91138 ? 296 VAL A C   1 
ATOM   2240 O O   . VAL A 1 296 ? -23.67510 -22.49705 16.61660  1.000 46.70582 ? 296 VAL A O   1 
ATOM   2241 C CB  . VAL A 1 296 ? -22.07990 -23.46514 13.78957  1.000 36.60173 ? 296 VAL A CB  1 
ATOM   2242 C CG1 . VAL A 1 296 ? -23.17450 -24.52306 14.06705  1.000 41.60353 ? 296 VAL A CG1 1 
ATOM   2243 C CG2 . VAL A 1 296 ? -22.01467 -23.13424 12.29365  1.000 34.72304 ? 296 VAL A CG2 1 
ATOM   2244 N N   . VAL A 1 297 ? -21.48972 -23.00920 16.76797  1.000 46.01924 ? 297 VAL A N   1 
ATOM   2245 C CA  . VAL A 1 297 ? -21.58527 -23.36199 18.18032  1.000 45.61804 ? 297 VAL A CA  1 
ATOM   2246 C C   . VAL A 1 297 ? -22.14710 -22.20033 18.98952  1.000 51.14909 ? 297 VAL A C   1 
ATOM   2247 O O   . VAL A 1 297 ? -23.01554 -22.38418 19.84840  1.000 51.18658 ? 297 VAL A O   1 
ATOM   2248 C CB  . VAL A 1 297 ? -20.20890 -23.80772 18.70415  1.000 47.08825 ? 297 VAL A CB  1 
ATOM   2249 C CG1 . VAL A 1 297 ? -20.19740 -23.80196 20.21575  1.000 49.28623 ? 297 VAL A CG1 1 
ATOM   2250 C CG2 . VAL A 1 297 ? -19.88445 -25.18794 18.17693  1.000 42.18850 ? 297 VAL A CG2 1 
ATOM   2251 N N   . ARG A 1 298 ? -21.67897 -20.98180 18.71762  1.000 45.64763 ? 298 ARG A N   1 
ATOM   2252 C CA  . ARG A 1 298 ? -22.14326 -19.83833 19.49110  1.000 46.12522 ? 298 ARG A CA  1 
ATOM   2253 C C   . ARG A 1 298 ? -23.63444 -19.61294 19.28943  1.000 50.53880 ? 298 ARG A C   1 
ATOM   2254 O O   . ARG A 1 298 ? -24.37035 -19.36647 20.25131  1.000 51.63712 ? 298 ARG A O   1 
ATOM   2255 C CB  . ARG A 1 298 ? -21.32567 -18.59437 19.11620  1.000 50.14410 ? 298 ARG A CB  1 
ATOM   2256 C CG  . ARG A 1 298 ? -22.01049 -17.24284 19.35263  1.000 55.58687 ? 298 ARG A CG  1 
ATOM   2257 C CD  . ARG A 1 298 ? -21.28415 -16.09897 18.56958  1.000 56.74869 ? 298 ARG A CD  1 
ATOM   2258 N NE  . ARG A 1 298 ? -22.16390 -14.95089 18.36274  1.000 57.77816 ? 298 ARG A NE  1 
ATOM   2259 C CZ  . ARG A 1 298 ? -22.17345 -14.16767 17.28762  1.000 59.31999 ? 298 ARG A CZ  1 
ATOM   2260 N NH1 . ARG A 1 298 ? -21.31122 -14.33548 16.29284  1.000 55.78987 ? 298 ARG A NH1 1 
ATOM   2261 N NH2 . ARG A 1 298 ? -23.08619 -13.20103 17.19997  1.000 52.25495 ? 298 ARG A NH2 1 
ATOM   2262 N N   . GLN A 1 299 ? -24.11343 -19.72276 18.05428  1.000 46.74621 ? 299 GLN A N   1 
ATOM   2263 C CA  . GLN A 1 299 ? -25.51711 -19.40905 17.83474  1.000 46.39361 ? 299 GLN A CA  1 
ATOM   2264 C C   . GLN A 1 299 ? -26.41651 -20.56318 18.25733  1.000 54.02406 ? 299 GLN A C   1 
ATOM   2265 O O   . GLN A 1 299 ? -27.47278 -20.34267 18.86428  1.000 56.01560 ? 299 GLN A O   1 
ATOM   2266 C CB  . GLN A 1 299 ? -25.75590 -19.04116 16.36999  1.000 44.18104 ? 299 GLN A CB  1 
ATOM   2267 C CG  . GLN A 1 299 ? -27.21986 -18.83790 16.07317  1.000 45.78186 ? 299 GLN A CG  1 
ATOM   2268 C CD  . GLN A 1 299 ? -27.48447 -18.12163 14.77636  1.000 46.18716 ? 299 GLN A CD  1 
ATOM   2269 O OE1 . GLN A 1 299 ? -28.64001 -17.92973 14.40143  1.000 44.85741 ? 299 GLN A OE1 1 
ATOM   2270 N NE2 . GLN A 1 299 ? -26.42380 -17.70377 14.08508  1.000 44.67081 ? 299 GLN A NE2 1 
ATOM   2271 N N   . CYS A 1 300 ? -26.00729 -21.79794 17.95988  1.000 51.70552 ? 300 CYS A N   1 
ATOM   2272 C CA  . CYS A 1 300 ? -26.81264 -22.97328 18.27038  1.000 49.68057 ? 300 CYS A CA  1 
ATOM   2273 C C   . CYS A 1 300 ? -26.81167 -23.31638 19.75773  1.000 58.27054 ? 300 CYS A C   1 
ATOM   2274 O O   . CYS A 1 300 ? -27.62974 -24.14226 20.18796  1.000 66.49123 ? 300 CYS A O   1 
ATOM   2275 C CB  . CYS A 1 300 ? -26.31880 -24.16040 17.43688  1.000 43.10352 ? 300 CYS A CB  1 
ATOM   2276 S SG  . CYS A 1 300 ? -26.70074 -23.98230 15.66936  1.000 51.40174 ? 300 CYS A SG  1 
ATOM   2277 N N   . SER A 1 301 ? -25.93573 -22.69353 20.54570  1.000 63.42807 ? 301 SER A N   1 
ATOM   2278 C CA  . SER A 1 301 ? -25.89961 -22.87850 21.99397  1.000 65.76391 ? 301 SER A CA  1 
ATOM   2279 C C   . SER A 1 301 ? -25.94784 -21.52484 22.71106  1.000 63.85838 ? 301 SER A C   1 
ATOM   2280 O O   . SER A 1 301 ? -26.15480 -21.45568 23.92844  1.000 62.57907 ? 301 SER A O   1 
ATOM   2281 C CB  . SER A 1 301 ? -24.64271 -23.66073 22.40594  1.000 65.90767 ? 301 SER A CB  1 
ATOM   2282 N N   . SER B 1 1   ? -21.09709 0.74757   -2.58131  1.000 40.89086 ? 1   SER B N   1 
ATOM   2283 C CA  . SER B 1 1   ? -21.92768 -0.29063  -3.16713  1.000 45.45176 ? 1   SER B CA  1 
ATOM   2284 C C   . SER B 1 1   ? -21.92324 -1.54301  -2.27953  1.000 39.50668 ? 1   SER B C   1 
ATOM   2285 O O   . SER B 1 1   ? -21.28090 -1.56252  -1.22209  1.000 40.91440 ? 1   SER B O   1 
ATOM   2286 C CB  . SER B 1 1   ? -21.45119 -0.61461  -4.59512  1.000 40.69901 ? 1   SER B CB  1 
ATOM   2287 O OG  . SER B 1 1   ? -20.85616 -1.90091  -4.67094  1.000 44.97187 ? 1   SER B OG  1 
ATOM   2288 N N   . GLY B 1 2   ? -22.62048 -2.57473  -2.72380  1.000 38.75949 ? 2   GLY B N   1 
ATOM   2289 C CA  . GLY B 1 2   ? -22.82939 -3.79088  -1.96197  1.000 42.43089 ? 2   GLY B CA  1 
ATOM   2290 C C   . GLY B 1 2   ? -24.18225 -3.79037  -1.26654  1.000 40.17531 ? 2   GLY B C   1 
ATOM   2291 O O   . GLY B 1 2   ? -24.76719 -2.74058  -0.98541  1.000 42.67229 ? 2   GLY B O   1 
ATOM   2292 N N   . PHE B 1 3   ? -24.68895 -4.98558  -0.95866  1.000 39.86402 ? 3   PHE B N   1 
ATOM   2293 C CA  . PHE B 1 3   ? -26.02797 -5.08881  -0.38348  1.000 44.16678 ? 3   PHE B CA  1 
ATOM   2294 C C   . PHE B 1 3   ? -26.06832 -6.22588  0.61959   1.000 45.29669 ? 3   PHE B C   1 
ATOM   2295 O O   . PHE B 1 3   ? -25.83574 -7.38199  0.25647   1.000 43.88993 ? 3   PHE B O   1 
ATOM   2296 C CB  . PHE B 1 3   ? -27.09076 -5.29556  -1.46558  1.000 40.66529 ? 3   PHE B CB  1 
ATOM   2297 C CG  . PHE B 1 3   ? -28.45132 -4.82075  -1.04566  1.000 42.99030 ? 3   PHE B CG  1 
ATOM   2298 C CD1 . PHE B 1 3   ? -28.72084 -3.46550  -0.94896  1.000 44.41727 ? 3   PHE B CD1 1 
ATOM   2299 C CD2 . PHE B 1 3   ? -29.44154 -5.71998  -0.70860  1.000 42.35170 ? 3   PHE B CD2 1 
ATOM   2300 C CE1 . PHE B 1 3   ? -29.96461 -3.01772  -0.53242  1.000 46.88320 ? 3   PHE B CE1 1 
ATOM   2301 C CE2 . PHE B 1 3   ? -30.69750 -5.27889  -0.30263  1.000 42.85760 ? 3   PHE B CE2 1 
ATOM   2302 C CZ  . PHE B 1 3   ? -30.95182 -3.92758  -0.21084  1.000 40.56770 ? 3   PHE B CZ  1 
ATOM   2303 N N   . ARG B 1 4   ? -26.36158 -5.89933  1.87644   1.000 42.22788 ? 4   ARG B N   1 
ATOM   2304 C CA  . ARG B 1 4   ? -26.32146 -6.86668  2.95818   1.000 43.65700 ? 4   ARG B CA  1 
ATOM   2305 C C   . ARG B 1 4   ? -27.58162 -6.75408  3.81224   1.000 41.18988 ? 4   ARG B C   1 
ATOM   2306 O O   . ARG B 1 4   ? -28.17257 -5.67309  3.94543   1.000 36.87161 ? 4   ARG B O   1 
ATOM   2307 C CB  . ARG B 1 4   ? -25.05916 -6.65680  3.82054   1.000 42.77295 ? 4   ARG B CB  1 
ATOM   2308 C CG  . ARG B 1 4   ? -23.85446 -7.47610  3.36385   1.000 42.78987 ? 4   ARG B CG  1 
ATOM   2309 C CD  . ARG B 1 4   ? -24.14752 -8.95418  3.58237   1.000 45.67502 ? 4   ARG B CD  1 
ATOM   2310 N NE  . ARG B 1 4   ? -23.02905 -9.83129  3.26318   1.000 58.52050 ? 4   ARG B NE  1 
ATOM   2311 C CZ  . ARG B 1 4   ? -21.85131 -9.78178  3.86771   1.000 52.17165 ? 4   ARG B CZ  1 
ATOM   2312 N NH1 . ARG B 1 4   ? -21.57409 -8.82754  4.73940   1.000 47.15695 ? 4   ARG B NH1 1 
ATOM   2313 N NH2 . ARG B 1 4   ? -20.92567 -10.70762 3.58183   1.000 41.22846 ? 4   ARG B NH2 1 
ATOM   2314 N N   . LYS B 1 5   ? -28.00367 -7.88354  4.38186   1.000 39.51014 ? 5   LYS B N   1 
ATOM   2315 C CA  . LYS B 1 5   ? -29.03663 -7.84096  5.41236   1.000 34.28940 ? 5   LYS B CA  1 
ATOM   2316 C C   . LYS B 1 5   ? -28.44573 -7.18207  6.65055   1.000 34.53905 ? 5   LYS B C   1 
ATOM   2317 O O   . LYS B 1 5   ? -27.55874 -7.73987  7.30158   1.000 42.10477 ? 5   LYS B O   1 
ATOM   2318 C CB  . LYS B 1 5   ? -29.56243 -9.24303  5.70771   1.000 41.74629 ? 5   LYS B CB  1 
ATOM   2319 C CG  . LYS B 1 5   ? -31.08481 -9.30696  5.81059   1.000 41.04784 ? 5   LYS B CG  1 
ATOM   2320 C CD  . LYS B 1 5   ? -31.57635 -10.73516 5.52720   1.000 45.33865 ? 5   LYS B CD  1 
ATOM   2321 C CE  . LYS B 1 5   ? -33.10244 -10.84778 5.47018   1.000 52.59478 ? 5   LYS B CE  1 
ATOM   2322 N NZ  . LYS B 1 5   ? -33.84355 -11.01436 6.81187   1.000 48.81640 ? 5   LYS B NZ  1 
ATOM   2323 N N   . MET B 1 6   ? -28.89604 -5.96954  6.94123   1.000 33.65636 ? 6   MET B N   1 
ATOM   2324 C CA  . MET B 1 6   ? -28.24531 -5.07232  7.88320   1.000 37.12864 ? 6   MET B CA  1 
ATOM   2325 C C   . MET B 1 6   ? -29.20717 -4.72817  9.01876   1.000 35.97272 ? 6   MET B C   1 
ATOM   2326 O O   . MET B 1 6   ? -30.34033 -4.30804  8.76622   1.000 37.91697 ? 6   MET B O   1 
ATOM   2327 C CB  . MET B 1 6   ? -27.78644 -3.80565  7.13194   1.000 35.71724 ? 6   MET B CB  1 
ATOM   2328 C CG  . MET B 1 6   ? -27.16917 -2.74726  7.96868   1.000 42.63159 ? 6   MET B CG  1 
ATOM   2329 S SD  . MET B 1 6   ? -26.53854 -1.35277  6.98489   1.000 47.74821 ? 6   MET B SD  1 
ATOM   2330 C CE  . MET B 1 6   ? -25.90134 -2.21034  5.55986   1.000 44.84803 ? 6   MET B CE  1 
ATOM   2331 N N   . ALA B 1 7   ? -28.75712 -4.90171  10.25974  1.000 34.69665 ? 7   ALA B N   1 
ATOM   2332 C CA  . ALA B 1 7   ? -29.54344 -4.51229  11.42228  1.000 38.16713 ? 7   ALA B CA  1 
ATOM   2333 C C   . ALA B 1 7   ? -29.20742 -3.09461  11.86820  1.000 42.07782 ? 7   ALA B C   1 
ATOM   2334 O O   . ALA B 1 7   ? -28.17673 -2.52431  11.50704  1.000 37.98654 ? 7   ALA B O   1 
ATOM   2335 C CB  . ALA B 1 7   ? -29.31495 -5.46419  12.59086  1.000 39.03798 ? 7   ALA B CB  1 
ATOM   2336 N N   . PHE B 1 8   ? -30.11955 -2.52326  12.64766  1.000 42.91362 ? 8   PHE B N   1 
ATOM   2337 C CA  . PHE B 1 8   ? -29.85195 -1.26592  13.30692  1.000 41.25931 ? 8   PHE B CA  1 
ATOM   2338 C C   . PHE B 1 8   ? -28.83331 -1.47728  14.42143  1.000 38.11971 ? 8   PHE B C   1 
ATOM   2339 O O   . PHE B 1 8   ? -28.73740 -2.56685  14.98463  1.000 37.76721 ? 8   PHE B O   1 
ATOM   2340 C CB  . PHE B 1 8   ? -31.14482 -0.65759  13.85606  1.000 35.66945 ? 8   PHE B CB  1 
ATOM   2341 C CG  . PHE B 1 8   ? -31.99803 -0.02447  12.79598  1.000 39.67282 ? 8   PHE B CG  1 
ATOM   2342 C CD1 . PHE B 1 8   ? -31.65054 1.21122   12.25200  1.000 42.18975 ? 8   PHE B CD1 1 
ATOM   2343 C CD2 . PHE B 1 8   ? -33.12407 -0.67641  12.30830  1.000 38.96496 ? 8   PHE B CD2 1 
ATOM   2344 C CE1 . PHE B 1 8   ? -32.43687 1.80023   11.26626  1.000 41.12862 ? 8   PHE B CE1 1 
ATOM   2345 C CE2 . PHE B 1 8   ? -33.91724 -0.09905  11.31141  1.000 36.61122 ? 8   PHE B CE2 1 
ATOM   2346 C CZ  . PHE B 1 8   ? -33.56904 1.15116   10.79692  1.000 42.82612 ? 8   PHE B CZ  1 
ATOM   2347 N N   . PRO B 1 9   ? -28.00480 -0.47428  14.69706  1.000 40.36437 ? 9   PRO B N   1 
ATOM   2348 C CA  . PRO B 1 9   ? -27.07414 -0.58437  15.82336  1.000 43.48818 ? 9   PRO B CA  1 
ATOM   2349 C C   . PRO B 1 9   ? -27.86701 -0.76791  17.10160  1.000 42.20533 ? 9   PRO B C   1 
ATOM   2350 O O   . PRO B 1 9   ? -28.88388 -0.10882  17.31767  1.000 42.76664 ? 9   PRO B O   1 
ATOM   2351 C CB  . PRO B 1 9   ? -26.32093 0.75110   15.80388  1.000 42.62750 ? 9   PRO B CB  1 
ATOM   2352 C CG  . PRO B 1 9   ? -26.45906 1.23983   14.37984  1.000 45.16917 ? 9   PRO B CG  1 
ATOM   2353 C CD  . PRO B 1 9   ? -27.83096 0.77385   13.94007  1.000 41.17974 ? 9   PRO B CD  1 
ATOM   2354 N N   . SER B 1 10  ? -27.39436 -1.67771  17.94823  1.000 45.42494 ? 10  SER B N   1 
ATOM   2355 C CA  . SER B 1 10  ? -28.18536 -2.21589  19.04111  1.000 42.95444 ? 10  SER B CA  1 
ATOM   2356 C C   . SER B 1 10  ? -27.86917 -1.57699  20.37746  1.000 46.36139 ? 10  SER B C   1 
ATOM   2357 O O   . SER B 1 10  ? -28.47460 -1.96207  21.38096  1.000 45.70100 ? 10  SER B O   1 
ATOM   2358 C CB  . SER B 1 10  ? -27.96918 -3.71975  19.14847  1.000 41.88392 ? 10  SER B CB  1 
ATOM   2359 O OG  . SER B 1 10  ? -26.59371 -3.99235  19.36271  1.000 44.24467 ? 10  SER B OG  1 
ATOM   2360 N N   . GLY B 1 11  ? -26.94410 -0.61683  20.41468  1.000 41.46975 ? 11  GLY B N   1 
ATOM   2361 C CA  . GLY B 1 11  ? -26.55000 -0.02061  21.68384  1.000 43.62644 ? 11  GLY B CA  1 
ATOM   2362 C C   . GLY B 1 11  ? -27.72987 0.45243   22.50797  1.000 45.12967 ? 11  GLY B C   1 
ATOM   2363 O O   . GLY B 1 11  ? -27.85503 0.12200   23.68701  1.000 44.61571 ? 11  GLY B O   1 
ATOM   2364 N N   . LYS B 1 12  ? -28.61656 1.23089   21.89232  1.000 41.31603 ? 12  LYS B N   1 
ATOM   2365 C CA  . LYS B 1 12  ? -29.71067 1.83668   22.63526  1.000 43.45698 ? 12  LYS B CA  1 
ATOM   2366 C C   . LYS B 1 12  ? -30.62920 0.78273   23.23472  1.000 42.48222 ? 12  LYS B C   1 
ATOM   2367 O O   . LYS B 1 12  ? -31.20768 0.99436   24.30530  1.000 51.04153 ? 12  LYS B O   1 
ATOM   2368 C CB  . LYS B 1 12  ? -30.46944 2.79235   21.71412  1.000 42.45512 ? 12  LYS B CB  1 
ATOM   2369 C CG  . LYS B 1 12  ? -29.64877 4.03225   21.36538  1.000 46.18848 ? 12  LYS B CG  1 
ATOM   2370 C CD  . LYS B 1 12  ? -30.40194 4.99822   20.47908  1.000 49.03832 ? 12  LYS B CD  1 
ATOM   2371 C CE  . LYS B 1 12  ? -29.57654 6.26728   20.28237  1.000 51.50317 ? 12  LYS B CE  1 
ATOM   2372 N NZ  . LYS B 1 12  ? -28.19978 5.92874   19.83082  1.000 55.00808 ? 12  LYS B NZ  1 
ATOM   2373 N N   . VAL B 1 13  ? -30.74128 -0.37061  22.58475  1.000 43.11687 ? 13  VAL B N   1 
ATOM   2374 C CA  . VAL B 1 13  ? -31.59863 -1.43759  23.08900  1.000 42.48323 ? 13  VAL B CA  1 
ATOM   2375 C C   . VAL B 1 13  ? -30.86228 -2.29298  24.10620  1.000 45.36359 ? 13  VAL B C   1 
ATOM   2376 O O   . VAL B 1 13  ? -31.46495 -2.76081  25.07401  1.000 45.69347 ? 13  VAL B O   1 
ATOM   2377 C CB  . VAL B 1 13  ? -32.11733 -2.27976  21.92184  1.000 36.46861 ? 13  VAL B CB  1 
ATOM   2378 C CG1 . VAL B 1 13  ? -32.88082 -3.49137  22.46266  1.000 38.45623 ? 13  VAL B CG1 1 
ATOM   2379 C CG2 . VAL B 1 13  ? -32.99712 -1.41798  21.04221  1.000 36.67958 ? 13  VAL B CG2 1 
ATOM   2380 N N   . GLU B 1 14  ? -29.55488 -2.50510  23.91707  1.000 46.75190 ? 14  GLU B N   1 
ATOM   2381 C CA  . GLU B 1 14  ? -28.77760 -3.26333  24.89243  1.000 45.57929 ? 14  GLU B CA  1 
ATOM   2382 C C   . GLU B 1 14  ? -28.91870 -2.67859  26.29211  1.000 50.28073 ? 14  GLU B C   1 
ATOM   2383 O O   . GLU B 1 14  ? -29.01775 -3.41988  27.27717  1.000 50.74420 ? 14  GLU B O   1 
ATOM   2384 C CB  . GLU B 1 14  ? -27.30446 -3.28550  24.48926  1.000 45.75311 ? 14  GLU B CB  1 
ATOM   2385 C CG  . GLU B 1 14  ? -27.01263 -3.79042  23.08142  1.000 43.81455 ? 14  GLU B CG  1 
ATOM   2386 C CD  . GLU B 1 14  ? -25.55351 -3.60535  22.71770  1.000 46.52669 ? 14  GLU B CD  1 
ATOM   2387 O OE1 . GLU B 1 14  ? -24.72186 -3.55358  23.64057  1.000 47.75237 ? 14  GLU B OE1 1 
ATOM   2388 O OE2 . GLU B 1 14  ? -25.23399 -3.48855  21.52293  1.000 44.49086 ? 14  GLU B OE2 1 
ATOM   2389 N N   . GLY B 1 15  ? -28.91630 -1.34604  26.40059  1.000 51.68277 ? 15  GLY B N   1 
ATOM   2390 C CA  . GLY B 1 15  ? -28.98111 -0.68168  27.69155  1.000 53.03165 ? 15  GLY B CA  1 
ATOM   2391 C C   . GLY B 1 15  ? -30.32768 -0.80943  28.38200  1.000 52.72819 ? 15  GLY B C   1 
ATOM   2392 O O   . GLY B 1 15  ? -30.52734 -0.31938  29.49842  1.000 49.05542 ? 15  GLY B O   1 
ATOM   2393 N N   . CYS B 1 16  ? -31.26537 -1.46563  27.71327  1.000 47.97551 ? 16  CYS B N   1 
ATOM   2394 C CA  . CYS B 1 16  ? -32.60395 -1.65806  28.23950  1.000 48.25613 ? 16  CYS B CA  1 
ATOM   2395 C C   . CYS B 1 16  ? -32.88539 -3.09541  28.65462  1.000 49.54767 ? 16  CYS B C   1 
ATOM   2396 O O   . CYS B 1 16  ? -33.97203 -3.36653  29.16721  1.000 50.42537 ? 16  CYS B O   1 
ATOM   2397 C CB  . CYS B 1 16  ? -33.63726 -1.21547  27.20215  1.000 45.38890 ? 16  CYS B CB  1 
ATOM   2398 S SG  . CYS B 1 16  ? -33.53207 0.50497   26.74473  1.000 50.34347 ? 16  CYS B SG  1 
ATOM   2399 N N   . MET B 1 17  ? -31.95277 -4.02584  28.44865  1.000 49.53707 ? 17  MET B N   1 
ATOM   2400 C CA  . MET B 1 17  ? -32.24038 -5.43844  28.68095  1.000 50.14904 ? 17  MET B CA  1 
ATOM   2401 C C   . MET B 1 17  ? -31.95419 -5.81896  30.13148  1.000 51.66494 ? 17  MET B C   1 
ATOM   2402 O O   . MET B 1 17  ? -30.90287 -5.47643  30.68120  1.000 54.39208 ? 17  MET B O   1 
ATOM   2403 C CB  . MET B 1 17  ? -31.43597 -6.33087  27.73182  1.000 50.30596 ? 17  MET B CB  1 
ATOM   2404 C CG  . MET B 1 17  ? -31.74584 -6.11738  26.25449  1.000 49.56355 ? 17  MET B CG  1 
ATOM   2405 S SD  . MET B 1 17  ? -33.52357 -6.01552  25.90345  1.000 46.89940 ? 17  MET B SD  1 
ATOM   2406 C CE  . MET B 1 17  ? -34.16384 -7.59532  26.50611  1.000 44.75518 ? 17  MET B CE  1 
ATOM   2407 N N   . VAL B 1 18  ? -32.89047 -6.53943  30.74643  1.000 52.70564 ? 18  VAL B N   1 
ATOM   2408 C CA  . VAL B 1 18  ? -32.73945 -7.00422  32.11659  1.000 53.62046 ? 18  VAL B CA  1 
ATOM   2409 C C   . VAL B 1 18  ? -33.19144 -8.45454  32.19812  1.000 54.14353 ? 18  VAL B C   1 
ATOM   2410 O O   . VAL B 1 18  ? -33.79297 -9.00014  31.27131  1.000 52.49961 ? 18  VAL B O   1 
ATOM   2411 C CB  . VAL B 1 18  ? -33.52355 -6.13509  33.11949  1.000 54.48033 ? 18  VAL B CB  1 
ATOM   2412 C CG1 . VAL B 1 18  ? -33.05973 -4.68282  33.03318  1.000 51.93171 ? 18  VAL B CG1 1 
ATOM   2413 C CG2 . VAL B 1 18  ? -35.02280 -6.25311  32.87424  1.000 48.53536 ? 18  VAL B CG2 1 
ATOM   2414 N N   . GLN B 1 19  ? -32.87904 -9.07933  33.32801  1.000 57.78123 ? 19  GLN B N   1 
ATOM   2415 C CA  . GLN B 1 19  ? -33.29504 -10.44115 33.61741  1.000 57.79920 ? 19  GLN B CA  1 
ATOM   2416 C C   . GLN B 1 19  ? -34.50620 -10.41586 34.53748  1.000 57.03215 ? 19  GLN B C   1 
ATOM   2417 O O   . GLN B 1 19  ? -34.56793 -9.62164  35.48110  1.000 61.69958 ? 19  GLN B O   1 
ATOM   2418 C CB  . GLN B 1 19  ? -32.15626 -11.23089 34.26623  1.000 61.86364 ? 19  GLN B CB  1 
ATOM   2419 C CG  . GLN B 1 19  ? -32.35652 -12.73107 34.22326  1.000 61.39758 ? 19  GLN B CG  1 
ATOM   2420 C CD  . GLN B 1 19  ? -31.40077 -13.47493 35.13085  1.000 65.22681 ? 19  GLN B CD  1 
ATOM   2421 O OE1 . GLN B 1 19  ? -30.53082 -14.21439 34.66421  1.000 60.74955 ? 19  GLN B OE1 1 
ATOM   2422 N NE2 . GLN B 1 19  ? -31.56893 -13.29825 36.44081  1.000 71.84048 ? 19  GLN B NE2 1 
ATOM   2423 N N   . VAL B 1 20  ? -35.47703 -11.27631 34.25754  1.000 57.93850 ? 20  VAL B N   1 
ATOM   2424 C CA  . VAL B 1 20  ? -36.66691 -11.37730 35.08848  1.000 55.57898 ? 20  VAL B CA  1 
ATOM   2425 C C   . VAL B 1 20  ? -36.85101 -12.83546 35.47664  1.000 58.03788 ? 20  VAL B C   1 
ATOM   2426 O O   . VAL B 1 20  ? -36.97225 -13.70513 34.60579  1.000 57.39130 ? 20  VAL B O   1 
ATOM   2427 C CB  . VAL B 1 20  ? -37.91735 -10.83349 34.38295  1.000 56.02871 ? 20  VAL B CB  1 
ATOM   2428 C CG1 . VAL B 1 20  ? -39.15224 -11.03159 35.27575  1.000 56.41885 ? 20  VAL B CG1 1 
ATOM   2429 C CG2 . VAL B 1 20  ? -37.73168 -9.37251  34.05432  1.000 52.09986 ? 20  VAL B CG2 1 
ATOM   2430 N N   . THR B 1 21  ? -36.86819 -13.10319 36.77967  1.000 61.25888 ? 21  THR B N   1 
ATOM   2431 C CA  . THR B 1 21  ? -36.97024 -14.45618 37.30443  1.000 58.98448 ? 21  THR B CA  1 
ATOM   2432 C C   . THR B 1 21  ? -38.18892 -14.54060 38.21086  1.000 60.78935 ? 21  THR B C   1 
ATOM   2433 O O   . THR B 1 21  ? -38.36814 -13.69609 39.09323  1.000 60.43018 ? 21  THR B O   1 
ATOM   2434 C CB  . THR B 1 21  ? -35.70197 -14.84015 38.07388  1.000 61.78193 ? 21  THR B CB  1 
ATOM   2435 O OG1 . THR B 1 21  ? -34.54653 -14.37657 37.36180  1.000 67.64380 ? 21  THR B OG1 1 
ATOM   2436 C CG2 . THR B 1 21  ? -35.61265 -16.34876 38.23075  1.000 65.37448 ? 21  THR B CG2 1 
ATOM   2437 N N   . CYS B 1 22  ? -39.02775 -15.55061 37.98593  1.000 63.70556 ? 22  CYS B N   1 
ATOM   2438 C CA  . CYS B 1 22  ? -40.22428 -15.76802 38.79553  1.000 64.79809 ? 22  CYS B CA  1 
ATOM   2439 C C   . CYS B 1 22  ? -40.33175 -17.26129 39.06385  1.000 64.73583 ? 22  CYS B C   1 
ATOM   2440 O O   . CYS B 1 22  ? -40.60465 -18.04129 38.14648  1.000 64.74292 ? 22  CYS B O   1 
ATOM   2441 C CB  . CYS B 1 22  ? -41.47560 -15.24253 38.09384  1.000 63.17597 ? 22  CYS B CB  1 
ATOM   2442 S SG  . CYS B 1 22  ? -43.00509 -15.48866 39.03173  1.000 73.03200 ? 22  CYS B SG  1 
ATOM   2443 N N   . GLY B 1 23  ? -40.12200 -17.66155 40.31207  1.000 64.68613 ? 23  GLY B N   1 
ATOM   2444 C CA  . GLY B 1 23  ? -40.01761 -19.07293 40.60293  1.000 64.68485 ? 23  GLY B CA  1 
ATOM   2445 C C   . GLY B 1 23  ? -38.74482 -19.60023 39.98501  1.000 63.27057 ? 23  GLY B C   1 
ATOM   2446 O O   . GLY B 1 23  ? -37.65782 -19.10336 40.29566  1.000 68.96746 ? 23  GLY B O   1 
ATOM   2447 N N   . THR B 1 24  ? -38.85937 -20.58379 39.09266  1.000 62.77843 ? 24  THR B N   1 
ATOM   2448 C CA  . THR B 1 24  ? -37.71658 -21.07955 38.33473  1.000 68.79288 ? 24  THR B CA  1 
ATOM   2449 C C   . THR B 1 24  ? -37.85440 -20.81261 36.83545  1.000 66.64024 ? 24  THR B C   1 
ATOM   2450 O O   . THR B 1 24  ? -37.28154 -21.53337 36.01501  1.000 70.82958 ? 24  THR B O   1 
ATOM   2451 C CB  . THR B 1 24  ? -37.51050 -22.57186 38.58062  1.000 68.43371 ? 24  THR B CB  1 
ATOM   2452 O OG1 . THR B 1 24  ? -38.75754 -23.25330 38.40867  1.000 65.29111 ? 24  THR B OG1 1 
ATOM   2453 C CG2 . THR B 1 24  ? -36.95703 -22.81412 39.97658  1.000 62.77776 ? 24  THR B CG2 1 
ATOM   2454 N N   . THR B 1 25  ? -38.61940 -19.79579 36.45963  1.000 64.88261 ? 25  THR B N   1 
ATOM   2455 C CA  . THR B 1 25  ? -38.71124 -19.35622 35.07420  1.000 62.98606 ? 25  THR B CA  1 
ATOM   2456 C C   . THR B 1 25  ? -37.94357 -18.04777 34.94895  1.000 60.51739 ? 25  THR B C   1 
ATOM   2457 O O   . THR B 1 25  ? -38.23922 -17.07993 35.66057  1.000 57.09143 ? 25  THR B O   1 
ATOM   2458 C CB  . THR B 1 25  ? -40.16977 -19.18378 34.64382  1.000 64.59507 ? 25  THR B CB  1 
ATOM   2459 O OG1 . THR B 1 25  ? -40.83112 -20.45369 34.67779  1.000 67.26225 ? 25  THR B OG1 1 
ATOM   2460 C CG2 . THR B 1 25  ? -40.25617 -18.62106 33.22932  1.000 57.82401 ? 25  THR B CG2 1 
ATOM   2461 N N   . THR B 1 26  ? -36.94535 -18.02592 34.06795  1.000 61.84711 ? 26  THR B N   1 
ATOM   2462 C CA  . THR B 1 26  ? -36.15383 -16.83018 33.81614  1.000 57.10256 ? 26  THR B CA  1 
ATOM   2463 C C   . THR B 1 26  ? -36.23424 -16.50120 32.33647  1.000 53.61893 ? 26  THR B C   1 
ATOM   2464 O O   . THR B 1 26  ? -35.93496 -17.34893 31.49084  1.000 52.34000 ? 26  THR B O   1 
ATOM   2465 C CB  . THR B 1 26  ? -34.69741 -17.02223 34.23717  1.000 59.12843 ? 26  THR B CB  1 
ATOM   2466 O OG1 . THR B 1 26  ? -34.62928 -17.17939 35.65632  1.000 64.69421 ? 26  THR B OG1 1 
ATOM   2467 C CG2 . THR B 1 26  ? -33.87002 -15.81419 33.83805  1.000 57.61703 ? 26  THR B CG2 1 
ATOM   2468 N N   . LEU B 1 27  ? -36.63745 -15.27784 32.02754  1.000 52.65585 ? 27  LEU B N   1 
ATOM   2469 C CA  . LEU B 1 27  ? -36.56549 -14.77022 30.66933  1.000 50.00095 ? 27  LEU B CA  1 
ATOM   2470 C C   . LEU B 1 27  ? -36.05149 -13.33263 30.73311  1.000 50.92480 ? 27  LEU B C   1 
ATOM   2471 O O   . LEU B 1 27  ? -35.62745 -12.84720 31.79116  1.000 50.98227 ? 27  LEU B O   1 
ATOM   2472 C CB  . LEU B 1 27  ? -37.92490 -14.90988 29.97459  1.000 46.82300 ? 27  LEU B CB  1 
ATOM   2473 C CG  . LEU B 1 27  ? -39.13739 -14.61853 30.84005  1.000 47.86325 ? 27  LEU B CG  1 
ATOM   2474 C CD1 . LEU B 1 27  ? -39.20256 -13.14795 31.15782  1.000 48.25892 ? 27  LEU B CD1 1 
ATOM   2475 C CD2 . LEU B 1 27  ? -40.37729 -15.06349 30.10956  1.000 49.47599 ? 27  LEU B CD2 1 
ATOM   2476 N N   . ASN B 1 28  ? -36.09333 -12.64857 29.59022  1.000 44.08814 ? 28  ASN B N   1 
ATOM   2477 C CA  . ASN B 1 28  ? -35.57754 -11.29085 29.45684  1.000 44.44774 ? 28  ASN B CA  1 
ATOM   2478 C C   . ASN B 1 28  ? -36.71104 -10.29468 29.60891  1.000 44.55626 ? 28  ASN B C   1 
ATOM   2479 O O   . ASN B 1 28  ? -37.86769 -10.60998 29.32589  1.000 49.04307 ? 28  ASN B O   1 
ATOM   2480 C CB  . ASN B 1 28  ? -34.91471 -11.07522 28.08856  1.000 41.09638 ? 28  ASN B CB  1 
ATOM   2481 C CG  . ASN B 1 28  ? -33.79231 -12.03900 27.82218  1.000 42.10419 ? 28  ASN B CG  1 
ATOM   2482 O OD1 . ASN B 1 28  ? -32.69556 -11.89913 28.37195  1.000 47.80012 ? 28  ASN B OD1 1 
ATOM   2483 N ND2 . ASN B 1 28  ? -34.05064 -13.03110 26.97108  1.000 44.18608 ? 28  ASN B ND2 1 
ATOM   2484 N N   . GLY B 1 29  ? -36.37055 -9.07528  30.02085  1.000 46.93608 ? 29  GLY B N   1 
ATOM   2485 C CA  . GLY B 1 29  ? -37.35537 -8.01655  30.11864  1.000 47.03444 ? 29  GLY B CA  1 
ATOM   2486 C C   . GLY B 1 29  ? -36.79033 -6.71377  29.58714  1.000 47.91978 ? 29  GLY B C   1 
ATOM   2487 O O   . GLY B 1 29  ? -35.57679 -6.55456  29.44088  1.000 49.53875 ? 29  GLY B O   1 
ATOM   2488 N N   . LEU B 1 30  ? -37.69135 -5.77610  29.29786  1.000 43.78455 ? 30  LEU B N   1 
ATOM   2489 C CA  . LEU B 1 30  ? -37.31736 -4.48230  28.73499  1.000 50.54230 ? 30  LEU B CA  1 
ATOM   2490 C C   . LEU B 1 30  ? -37.54544 -3.38657  29.77318  1.000 52.11084 ? 30  LEU B C   1 
ATOM   2491 O O   . LEU B 1 30  ? -38.69253 -3.06841  30.10619  1.000 50.17223 ? 30  LEU B O   1 
ATOM   2492 C CB  . LEU B 1 30  ? -38.10378 -4.19041  27.45749  1.000 51.57095 ? 30  LEU B CB  1 
ATOM   2493 C CG  . LEU B 1 30  ? -37.52993 -3.02764  26.64413  1.000 47.46383 ? 30  LEU B CG  1 
ATOM   2494 C CD1 . LEU B 1 30  ? -36.21379 -3.46359  26.01004  1.000 43.57285 ? 30  LEU B CD1 1 
ATOM   2495 C CD2 . LEU B 1 30  ? -38.51536 -2.52494  25.59406  1.000 45.63118 ? 30  LEU B CD2 1 
ATOM   2496 N N   . TRP B 1 31  ? -36.45075 -2.77578  30.23637  1.000 52.44958 ? 31  TRP B N   1 
ATOM   2497 C CA  . TRP B 1 31  ? -36.47297 -1.77061  31.29767  1.000 51.54923 ? 31  TRP B CA  1 
ATOM   2498 C C   . TRP B 1 31  ? -36.45729 -0.38816  30.64932  1.000 52.40824 ? 31  TRP B C   1 
ATOM   2499 O O   . TRP B 1 31  ? -35.41795 0.08276   30.17581  1.000 53.65249 ? 31  TRP B O   1 
ATOM   2500 C CB  . TRP B 1 31  ? -35.29369 -1.99170  32.24272  1.000 53.22363 ? 31  TRP B CB  1 
ATOM   2501 C CG  . TRP B 1 31  ? -35.19374 -1.03929  33.42543  1.000 59.65536 ? 31  TRP B CG  1 
ATOM   2502 C CD1 . TRP B 1 31  ? -36.21473 -0.36055  34.03382  1.000 58.04616 ? 31  TRP B CD1 1 
ATOM   2503 C CD2 . TRP B 1 31  ? -33.99465 -0.67137  34.13042  1.000 59.64563 ? 31  TRP B CD2 1 
ATOM   2504 N NE1 . TRP B 1 31  ? -35.72728 0.39658   35.07351  1.000 56.61451 ? 31  TRP B NE1 1 
ATOM   2505 C CE2 . TRP B 1 31  ? -34.36935 0.22423   35.15373  1.000 62.36233 ? 31  TRP B CE2 1 
ATOM   2506 C CE3 . TRP B 1 31  ? -32.64405 -1.01798  33.99725  1.000 60.66892 ? 31  TRP B CE3 1 
ATOM   2507 C CZ2 . TRP B 1 31  ? -33.44202 0.78476   36.03125  1.000 62.64234 ? 31  TRP B CZ2 1 
ATOM   2508 C CZ3 . TRP B 1 31  ? -31.72426 -0.46246  34.87429  1.000 63.99622 ? 31  TRP B CZ3 1 
ATOM   2509 C CH2 . TRP B 1 31  ? -32.13011 0.42863   35.87787  1.000 63.72902 ? 31  TRP B CH2 1 
ATOM   2510 N N   . LEU B 1 32  ? -37.62774 0.24187   30.59874  1.000 49.81967 ? 32  LEU B N   1 
ATOM   2511 C CA  . LEU B 1 32  ? -37.79930 1.59835   30.09367  1.000 51.52374 ? 32  LEU B CA  1 
ATOM   2512 C C   . LEU B 1 32  ? -38.39129 2.43903   31.21612  1.000 57.52723 ? 32  LEU B C   1 
ATOM   2513 O O   . LEU B 1 32  ? -39.44297 2.09160   31.76666  1.000 55.75875 ? 32  LEU B O   1 
ATOM   2514 C CB  . LEU B 1 32  ? -38.70730 1.62259   28.86108  1.000 51.05276 ? 32  LEU B CB  1 
ATOM   2515 C CG  . LEU B 1 32  ? -38.22650 0.83992   27.63153  1.000 51.43116 ? 32  LEU B CG  1 
ATOM   2516 C CD1 . LEU B 1 32  ? -39.31182 0.71740   26.56732  1.000 48.88099 ? 32  LEU B CD1 1 
ATOM   2517 C CD2 . LEU B 1 32  ? -37.00612 1.51826   27.06756  1.000 52.14551 ? 32  LEU B CD2 1 
ATOM   2518 N N   . ASP B 1 33  ? -37.71798 3.53571   31.56001  1.000 60.60095 ? 33  ASP B N   1 
ATOM   2519 C CA  . ASP B 1 33  ? -38.13523 4.30499   32.72255  1.000 60.82142 ? 33  ASP B CA  1 
ATOM   2520 C C   . ASP B 1 33  ? -38.22546 3.36463   33.91351  1.000 58.60991 ? 33  ASP B C   1 
ATOM   2521 O O   . ASP B 1 33  ? -37.40291 2.45165   34.04280  1.000 59.19969 ? 33  ASP B O   1 
ATOM   2522 C CB  . ASP B 1 33  ? -39.46827 5.00153   32.45218  1.000 57.37120 ? 33  ASP B CB  1 
ATOM   2523 C CG  . ASP B 1 33  ? -39.39991 5.91445   31.24492  1.000 63.70137 ? 33  ASP B CG  1 
ATOM   2524 O OD1 . ASP B 1 33  ? -38.42594 6.69754   31.15544  1.000 63.65791 ? 33  ASP B OD1 1 
ATOM   2525 O OD2 . ASP B 1 33  ? -40.29683 5.83635   30.37206  1.000 65.55530 ? 33  ASP B OD2 1 
ATOM   2526 N N   . ASP B 1 34  ? -39.22437 3.56010   34.77855  1.000 60.50145 ? 34  ASP B N   1 
ATOM   2527 C CA  . ASP B 1 34  ? -39.41029 2.70758   35.94607  1.000 62.85187 ? 34  ASP B CA  1 
ATOM   2528 C C   . ASP B 1 34  ? -40.36176 1.54002   35.67938  1.000 60.92545 ? 34  ASP B C   1 
ATOM   2529 O O   . ASP B 1 34  ? -41.06506 1.10067   36.59417  1.000 62.53522 ? 34  ASP B O   1 
ATOM   2530 C CB  . ASP B 1 34  ? -39.88543 3.54271   37.14034  1.000 63.01399 ? 34  ASP B CB  1 
ATOM   2531 C CG  . ASP B 1 34  ? -41.27779 4.13761   36.94310  1.000 71.56127 ? 34  ASP B CG  1 
ATOM   2532 O OD1 . ASP B 1 34  ? -41.89901 3.92159   35.87867  1.000 68.47953 ? 34  ASP B OD1 1 
ATOM   2533 O OD2 . ASP B 1 34  ? -41.75799 4.82616   37.87235  1.000 75.37196 ? 34  ASP B OD2 1 
ATOM   2534 N N   . VAL B 1 35  ? -40.39506 1.01705   34.45187  1.000 58.35959 ? 35  VAL B N   1 
ATOM   2535 C CA  . VAL B 1 35  ? -41.21747 -0.13721  34.10003  1.000 52.54780 ? 35  VAL B CA  1 
ATOM   2536 C C   . VAL B 1 35  ? -40.34533 -1.18964  33.43046  1.000 52.22380 ? 35  VAL B C   1 
ATOM   2537 O O   . VAL B 1 35  ? -39.46199 -0.86380  32.62570  1.000 52.27400 ? 35  VAL B O   1 
ATOM   2538 C CB  . VAL B 1 35  ? -42.38385 0.24549   33.16565  1.000 50.72829 ? 35  VAL B CB  1 
ATOM   2539 C CG1 . VAL B 1 35  ? -43.19608 -0.98969  32.81501  1.000 50.36623 ? 35  VAL B CG1 1 
ATOM   2540 C CG2 . VAL B 1 35  ? -43.25551 1.30615   33.79566  1.000 52.32367 ? 35  VAL B CG2 1 
ATOM   2541 N N   . VAL B 1 36  ? -40.59694 -2.45068  33.76069  1.000 47.99509 ? 36  VAL B N   1 
ATOM   2542 C CA  . VAL B 1 36  ? -39.99911 -3.59438  33.08000  1.000 48.88714 ? 36  VAL B CA  1 
ATOM   2543 C C   . VAL B 1 36  ? -41.13054 -4.34615  32.38824  1.000 53.52848 ? 36  VAL B C   1 
ATOM   2544 O O   . VAL B 1 36  ? -42.09581 -4.76093  33.04284  1.000 52.06348 ? 36  VAL B O   1 
ATOM   2545 C CB  . VAL B 1 36  ? -39.22447 -4.50923  34.05061  1.000 51.11228 ? 36  VAL B CB  1 
ATOM   2546 C CG1 . VAL B 1 36  ? -38.79087 -5.79229  33.36693  1.000 44.01622 ? 36  VAL B CG1 1 
ATOM   2547 C CG2 . VAL B 1 36  ? -37.98594 -3.78791  34.60274  1.000 51.92471 ? 36  VAL B CG2 1 
ATOM   2548 N N   . TYR B 1 37  ? -41.03083 -4.49146  31.06529  1.000 47.85912 ? 37  TYR B N   1 
ATOM   2549 C CA  . TYR B 1 37  ? -42.00048 -5.24067  30.27304  1.000 46.35987 ? 37  TYR B CA  1 
ATOM   2550 C C   . TYR B 1 37  ? -41.43195 -6.61669  29.95416  1.000 47.19446 ? 37  TYR B C   1 
ATOM   2551 O O   . TYR B 1 37  ? -40.28905 -6.71471  29.50014  1.000 49.30752 ? 37  TYR B O   1 
ATOM   2552 C CB  . TYR B 1 37  ? -42.31806 -4.50841  28.97027  1.000 47.71010 ? 37  TYR B CB  1 
ATOM   2553 C CG  . TYR B 1 37  ? -42.74600 -3.07097  29.13258  1.000 47.94953 ? 37  TYR B CG  1 
ATOM   2554 C CD1 . TYR B 1 37  ? -41.81316 -2.06222  29.34198  1.000 47.07965 ? 37  TYR B CD1 1 
ATOM   2555 C CD2 . TYR B 1 37  ? -44.08231 -2.71694  29.04726  1.000 46.28294 ? 37  TYR B CD2 1 
ATOM   2556 C CE1 . TYR B 1 37  ? -42.20738 -0.74048  29.48543  1.000 49.38887 ? 37  TYR B CE1 1 
ATOM   2557 C CE2 . TYR B 1 37  ? -44.48616 -1.40280  29.19336  1.000 47.28630 ? 37  TYR B CE2 1 
ATOM   2558 C CZ  . TYR B 1 37  ? -43.54069 -0.42042  29.41142  1.000 50.03274 ? 37  TYR B CZ  1 
ATOM   2559 O OH  . TYR B 1 37  ? -43.93242 0.88161   29.55232  1.000 48.89518 ? 37  TYR B OH  1 
ATOM   2560 N N   . CYS B 1 38  ? -42.21962 -7.67175  30.16787  1.000 48.14143 ? 38  CYS B N   1 
ATOM   2561 C CA  . CYS B 1 38  ? -41.77103 -9.01836  29.83590  1.000 43.65946 ? 38  CYS B CA  1 
ATOM   2562 C C   . CYS B 1 38  ? -42.97318 -9.88207  29.48322  1.000 45.68337 ? 38  CYS B C   1 
ATOM   2563 O O   . CYS B 1 38  ? -44.12228 -9.50017  29.74783  1.000 50.56362 ? 38  CYS B O   1 
ATOM   2564 C CB  . CYS B 1 38  ? -40.96096 -9.64338  30.98169  1.000 47.74566 ? 38  CYS B CB  1 
ATOM   2565 S SG  . CYS B 1 38  ? -41.90021 -9.96536  32.51450  1.000 49.72682 ? 38  CYS B SG  1 
ATOM   2566 N N   . PRO B 1 39  ? -42.75021 -11.04150 28.86260  1.000 41.39554 ? 39  PRO B N   1 
ATOM   2567 C CA  . PRO B 1 39  ? -43.87398 -11.93788 28.56845  1.000 47.12753 ? 39  PRO B CA  1 
ATOM   2568 C C   . PRO B 1 39  ? -44.52642 -12.38512 29.86143  1.000 47.53557 ? 39  PRO B C   1 
ATOM   2569 O O   . PRO B 1 39  ? -43.84672 -12.69520 30.84254  1.000 45.42367 ? 39  PRO B O   1 
ATOM   2570 C CB  . PRO B 1 39  ? -43.21780 -13.11098 27.83252  1.000 45.63006 ? 39  PRO B CB  1 
ATOM   2571 C CG  . PRO B 1 39  ? -41.91722 -12.52481 27.30201  1.000 40.74634 ? 39  PRO B CG  1 
ATOM   2572 C CD  . PRO B 1 39  ? -41.47509 -11.60335 28.39851  1.000 46.06251 ? 39  PRO B CD  1 
ATOM   2573 N N   . ARG B 1 40  ? -45.85774 -12.38896 29.86620  1.000 47.09449 ? 40  ARG B N   1 
ATOM   2574 C CA  . ARG B 1 40  ? -46.56782 -12.73051 31.09341  1.000 52.49699 ? 40  ARG B CA  1 
ATOM   2575 C C   . ARG B 1 40  ? -46.33516 -14.17427 31.51211  1.000 51.30065 ? 40  ARG B C   1 
ATOM   2576 O O   . ARG B 1 40  ? -46.44169 -14.47954 32.70709  1.000 54.49477 ? 40  ARG B O   1 
ATOM   2577 C CB  . ARG B 1 40  ? -48.06773 -12.45799 30.94599  1.000 47.97214 ? 40  ARG B CB  1 
ATOM   2578 C CG  . ARG B 1 40  ? -48.84795 -13.48605 30.15407  1.000 47.53534 ? 40  ARG B CG  1 
ATOM   2579 C CD  . ARG B 1 40  ? -50.30158 -13.05914 30.02913  1.000 44.24040 ? 40  ARG B CD  1 
ATOM   2580 N NE  . ARG B 1 40  ? -51.01646 -13.90331 29.08095  1.000 47.50492 ? 40  ARG B NE  1 
ATOM   2581 C CZ  . ARG B 1 40  ? -52.32204 -13.84478 28.85161  1.000 48.02547 ? 40  ARG B CZ  1 
ATOM   2582 N NH1 . ARG B 1 40  ? -53.10448 -13.00034 29.50937  1.000 47.23267 ? 40  ARG B NH1 1 
ATOM   2583 N NH2 . ARG B 1 40  ? -52.85525 -14.65041 27.93540  1.000 44.80584 ? 40  ARG B NH2 1 
ATOM   2584 N N   . HIS B 1 41  ? -45.99811 -15.06731 30.56766  1.000 49.20618 ? 41  HIS B N   1 
ATOM   2585 C CA  . HIS B 1 41  ? -45.84491 -16.45617 30.96622  1.000 47.77960 ? 41  HIS B CA  1 
ATOM   2586 C C   . HIS B 1 41  ? -44.61194 -16.69972 31.84716  1.000 51.66375 ? 41  HIS B C   1 
ATOM   2587 O O   . HIS B 1 41  ? -44.34142 -17.86293 32.19897  1.000 50.94638 ? 41  HIS B O   1 
ATOM   2588 C CB  . HIS B 1 41  ? -45.84182 -17.37286 29.73881  1.000 47.01153 ? 41  HIS B CB  1 
ATOM   2589 C CG  . HIS B 1 41  ? -44.63890 -17.24051 28.85634  1.000 52.93166 ? 41  HIS B CG  1 
ATOM   2590 N ND1 . HIS B 1 41  ? -43.42696 -17.83418 29.14714  1.000 51.45805 ? 41  HIS B ND1 1 
ATOM   2591 C CD2 . HIS B 1 41  ? -44.47870 -16.62842 27.66093  1.000 47.58767 ? 41  HIS B CD2 1 
ATOM   2592 C CE1 . HIS B 1 41  ? -42.56507 -17.57221 28.18293  1.000 49.60264 ? 41  HIS B CE1 1 
ATOM   2593 N NE2 . HIS B 1 41  ? -43.17849 -16.84457 27.26738  1.000 51.51203 ? 41  HIS B NE2 1 
ATOM   2594 N N   . VAL B 1 42  ? -43.88399 -15.65756 32.25947  1.000 48.12138 ? 42  VAL B N   1 
ATOM   2595 C CA  . VAL B 1 42  ? -42.84201 -15.83807 33.26806  1.000 49.74183 ? 42  VAL B CA  1 
ATOM   2596 C C   . VAL B 1 42  ? -43.42904 -16.30048 34.60286  1.000 57.13883 ? 42  VAL B C   1 
ATOM   2597 O O   . VAL B 1 42  ? -42.74626 -16.96060 35.39537  1.000 58.45415 ? 42  VAL B O   1 
ATOM   2598 C CB  . VAL B 1 42  ? -42.04902 -14.53813 33.44030  1.000 48.65568 ? 42  VAL B CB  1 
ATOM   2599 C CG1 . VAL B 1 42  ? -42.95024 -13.44768 33.99009  1.000 48.66368 ? 42  VAL B CG1 1 
ATOM   2600 C CG2 . VAL B 1 42  ? -40.83563 -14.77172 34.32453  1.000 53.92361 ? 42  VAL B CG2 1 
ATOM   2601 N N   . ILE B 1 43  ? -44.68591 -15.95363 34.88929  1.000 53.86692 ? 43  ILE B N   1 
ATOM   2602 C CA  . ILE B 1 43  ? -45.28395 -16.37825 36.15081  1.000 57.69871 ? 43  ILE B CA  1 
ATOM   2603 C C   . ILE B 1 43  ? -45.67349 -17.84618 36.15356  1.000 53.48569 ? 43  ILE B C   1 
ATOM   2604 O O   . ILE B 1 43  ? -45.92076 -18.40732 37.22453  1.000 62.95627 ? 43  ILE B O   1 
ATOM   2605 C CB  . ILE B 1 43  ? -46.53281 -15.54960 36.50271  1.000 50.83478 ? 43  ILE B CB  1 
ATOM   2606 C CG1 . ILE B 1 43  ? -47.67222 -15.88017 35.53697  1.000 46.73482 ? 43  ILE B CG1 1 
ATOM   2607 C CG2 . ILE B 1 43  ? -46.19424 -14.06613 36.57623  1.000 52.43077 ? 43  ILE B CG2 1 
ATOM   2608 C CD1 . ILE B 1 43  ? -48.91414 -15.06534 35.76292  1.000 52.86360 ? 43  ILE B CD1 1 
ATOM   2609 N N   . CYS B 1 44  ? -45.73593 -18.48230 34.99017  1.000 52.58915 ? 44  CYS B N   1 
ATOM   2610 C CA  . CYS B 1 44  ? -46.16878 -19.86496 34.90100  1.000 59.21057 ? 44  CYS B CA  1 
ATOM   2611 C C   . CYS B 1 44  ? -45.06708 -20.82192 35.32817  1.000 64.02252 ? 44  CYS B C   1 
ATOM   2612 O O   . CYS B 1 44  ? -43.87459 -20.51035 35.26059  1.000 65.86617 ? 44  CYS B O   1 
ATOM   2613 C CB  . CYS B 1 44  ? -46.60238 -20.19925 33.47770  1.000 60.40171 ? 44  CYS B CB  1 
ATOM   2614 S SG  . CYS B 1 44  ? -47.99462 -19.22382 32.93528  1.000 64.57706 ? 44  CYS B SG  1 
ATOM   2615 N N   . THR B 1 45  ? -45.49102 -21.99529 35.77494  1.000 67.45093 ? 45  THR B N   1 
ATOM   2616 C CA  . THR B 1 45  ? -44.62921 -23.12358 36.08132  1.000 70.29206 ? 45  THR B CA  1 
ATOM   2617 C C   . THR B 1 45  ? -44.61948 -24.07474 34.89196  1.000 76.50478 ? 45  THR B C   1 
ATOM   2618 O O   . THR B 1 45  ? -45.37162 -23.90389 33.93013  1.000 78.85097 ? 45  THR B O   1 
ATOM   2619 C CB  . THR B 1 45  ? -45.12760 -23.85008 37.33467  1.000 71.60473 ? 45  THR B CB  1 
ATOM   2620 O OG1 . THR B 1 45  ? -46.44706 -24.34933 37.08762  1.000 72.56764 ? 45  THR B OG1 1 
ATOM   2621 C CG2 . THR B 1 45  ? -45.17404 -22.90333 38.53445  1.000 65.32467 ? 45  THR B CG2 1 
ATOM   2622 N N   . SER B 1 46  ? -43.76821 -25.10089 34.97065  1.000 77.90125 ? 46  SER B N   1 
ATOM   2623 C CA  . SER B 1 46  ? -43.70902 -26.08240 33.89087  1.000 81.49763 ? 46  SER B CA  1 
ATOM   2624 C C   . SER B 1 46  ? -45.10020 -26.62886 33.57274  1.000 84.05091 ? 46  SER B C   1 
ATOM   2625 O O   . SER B 1 46  ? -45.56119 -26.56666 32.42478  1.000 84.79317 ? 46  SER B O   1 
ATOM   2626 C CB  . SER B 1 46  ? -42.74589 -27.21335 34.25980  1.000 79.49128 ? 46  SER B CB  1 
ATOM   2627 N N   . GLU B 1 47  ? -45.79470 -27.15022 34.58996  1.000 82.24190 ? 47  GLU B N   1 
ATOM   2628 C CA  . GLU B 1 47  ? -47.13205 -27.70075 34.39735  1.000 82.99141 ? 47  GLU B CA  1 
ATOM   2629 C C   . GLU B 1 47  ? -48.19729 -26.62421 34.20092  1.000 83.38547 ? 47  GLU B C   1 
ATOM   2630 O O   . GLU B 1 47  ? -49.27495 -26.92644 33.67315  1.000 86.21780 ? 47  GLU B O   1 
ATOM   2631 C CB  . GLU B 1 47  ? -47.50863 -28.59225 35.58416  1.000 72.95857 ? 47  GLU B CB  1 
ATOM   2632 N N   . ASP B 1 48  ? -47.92863 -25.38086 34.60746  1.000 79.77315 ? 48  ASP B N   1 
ATOM   2633 C CA  . ASP B 1 48  ? -48.89872 -24.30681 34.41872  1.000 78.90040 ? 48  ASP B CA  1 
ATOM   2634 C C   . ASP B 1 48  ? -48.96676 -23.81519 32.97821  1.000 77.42956 ? 48  ASP B C   1 
ATOM   2635 O O   . ASP B 1 48  ? -50.00227 -23.27662 32.57127  1.000 72.90155 ? 48  ASP B O   1 
ATOM   2636 C CB  . ASP B 1 48  ? -48.57245 -23.13268 35.34157  1.000 73.82272 ? 48  ASP B CB  1 
ATOM   2637 C CG  . ASP B 1 48  ? -49.50476 -23.05523 36.54054  1.000 75.00140 ? 48  ASP B CG  1 
ATOM   2638 O OD1 . ASP B 1 48  ? -50.69618 -23.41245 36.39065  1.000 73.61022 ? 48  ASP B OD1 1 
ATOM   2639 O OD2 . ASP B 1 48  ? -49.04820 -22.63180 37.62822  1.000 74.22426 ? 48  ASP B OD2 1 
ATOM   2640 N N   . MET B 1 49  ? -47.90010 -24.00508 32.19588  1.000 79.59524 ? 49  MET B N   1 
ATOM   2641 C CA  . MET B 1 49  ? -47.88077 -23.51266 30.82387  1.000 75.41588 ? 49  MET B CA  1 
ATOM   2642 C C   . MET B 1 49  ? -48.79020 -24.31287 29.89826  1.000 74.28696 ? 49  MET B C   1 
ATOM   2643 O O   . MET B 1 49  ? -49.10450 -23.83348 28.80555  1.000 72.32799 ? 49  MET B O   1 
ATOM   2644 C CB  . MET B 1 49  ? -46.44144 -23.50883 30.29101  1.000 75.69854 ? 49  MET B CB  1 
ATOM   2645 C CG  . MET B 1 49  ? -45.54051 -22.45511 30.96233  1.000 76.06059 ? 49  MET B CG  1 
ATOM   2646 S SD  . MET B 1 49  ? -43.79652 -22.38665 30.43939  1.000 79.89662 ? 49  MET B SD  1 
ATOM   2647 C CE  . MET B 1 49  ? -43.22329 -20.96838 31.38159  1.000 59.19909 ? 49  MET B CE  1 
ATOM   2648 N N   . LEU B 1 50  ? -49.23405 -25.50503 30.30922  1.000 76.01547 ? 50  LEU B N   1 
ATOM   2649 C CA  . LEU B 1 50  ? -50.06002 -26.33116 29.43010  1.000 72.66739 ? 50  LEU B CA  1 
ATOM   2650 C C   . LEU B 1 50  ? -51.34026 -25.60700 29.02563  1.000 68.27338 ? 50  LEU B C   1 
ATOM   2651 O O   . LEU B 1 50  ? -51.75154 -25.65326 27.85945  1.000 64.37673 ? 50  LEU B O   1 
ATOM   2652 C CB  . LEU B 1 50  ? -50.38115 -27.65986 30.11735  1.000 70.73521 ? 50  LEU B CB  1 
ATOM   2653 N N   . ASN B 1 51  ? -51.98317 -24.93825 29.97100  1.000 68.98552 ? 51  ASN B N   1 
ATOM   2654 C CA  . ASN B 1 51  ? -53.17885 -24.15998 29.68276  1.000 68.06619 ? 51  ASN B CA  1 
ATOM   2655 C C   . ASN B 1 51  ? -53.43914 -23.23678 30.86231  1.000 69.72600 ? 51  ASN B C   1 
ATOM   2656 O O   . ASN B 1 51  ? -54.33702 -23.49110 31.67852  1.000 71.53847 ? 51  ASN B O   1 
ATOM   2657 C CB  . ASN B 1 51  ? -54.38846 -25.05777 29.42121  1.000 74.93792 ? 51  ASN B CB  1 
ATOM   2658 C CG  . ASN B 1 51  ? -55.52838 -24.30882 28.75437  1.000 80.24056 ? 51  ASN B CG  1 
ATOM   2659 O OD1 . ASN B 1 51  ? -55.30443 -23.33688 28.02369  1.000 84.13418 ? 51  ASN B OD1 1 
ATOM   2660 N ND2 . ASN B 1 51  ? -56.75580 -24.74822 29.00641  1.000 81.86755 ? 51  ASN B ND2 1 
ATOM   2661 N N   . PRO B 1 52  ? -52.67483 -22.16070 30.98367  1.000 65.49203 ? 52  PRO B N   1 
ATOM   2662 C CA  . PRO B 1 52  ? -52.73230 -21.34763 32.19646  1.000 61.44608 ? 52  PRO B CA  1 
ATOM   2663 C C   . PRO B 1 52  ? -53.94165 -20.43556 32.23080  1.000 59.93401 ? 52  PRO B C   1 
ATOM   2664 O O   . PRO B 1 52  ? -54.49669 -20.04700 31.20162  1.000 65.05509 ? 52  PRO B O   1 
ATOM   2665 C CB  . PRO B 1 52  ? -51.43770 -20.53056 32.12579  1.000 64.12669 ? 52  PRO B CB  1 
ATOM   2666 C CG  . PRO B 1 52  ? -51.16781 -20.41313 30.66582  1.000 61.98611 ? 52  PRO B CG  1 
ATOM   2667 C CD  . PRO B 1 52  ? -51.62238 -21.70688 30.05691  1.000 64.48243 ? 52  PRO B CD  1 
ATOM   2668 N N   . ASN B 1 53  ? -54.34142 -20.09695 33.44955  1.000 59.63015 ? 53  ASN B N   1 
ATOM   2669 C CA  . ASN B 1 53  ? -55.31826 -19.04790 33.71521  1.000 59.75846 ? 53  ASN B CA  1 
ATOM   2670 C C   . ASN B 1 53  ? -54.52189 -17.91664 34.34700  1.000 59.94660 ? 53  ASN B C   1 
ATOM   2671 O O   . ASN B 1 53  ? -54.22659 -17.94841 35.54546  1.000 60.34575 ? 53  ASN B O   1 
ATOM   2672 C CB  . ASN B 1 53  ? -56.43988 -19.53633 34.62808  1.000 62.30591 ? 53  ASN B CB  1 
ATOM   2673 C CG  . ASN B 1 53  ? -57.53917 -18.50382 34.80119  1.000 66.25398 ? 53  ASN B CG  1 
ATOM   2674 O OD1 . ASN B 1 53  ? -57.27642 -17.30108 34.87913  1.000 62.29348 ? 53  ASN B OD1 1 
ATOM   2675 N ND2 . ASN B 1 53  ? -58.78288 -18.96978 34.85053  1.000 71.25226 ? 53  ASN B ND2 1 
ATOM   2676 N N   . TYR B 1 54  ? -54.15693 -16.92566 33.53082  1.000 60.47397 ? 54  TYR B N   1 
ATOM   2677 C CA  . TYR B 1 54  ? -53.14826 -15.96242 33.96010  1.000 57.06327 ? 54  TYR B CA  1 
ATOM   2678 C C   . TYR B 1 54  ? -53.69452 -15.01222 35.01663  1.000 54.10962 ? 54  TYR B C   1 
ATOM   2679 O O   . TYR B 1 54  ? -52.97237 -14.63383 35.94414  1.000 52.59879 ? 54  TYR B O   1 
ATOM   2680 C CB  . TYR B 1 54  ? -52.61179 -15.17376 32.76005  1.000 55.45641 ? 54  TYR B CB  1 
ATOM   2681 C CG  . TYR B 1 54  ? -51.64719 -15.93423 31.86333  1.000 50.95705 ? 54  TYR B CG  1 
ATOM   2682 C CD1 . TYR B 1 54  ? -50.31817 -16.11042 32.22350  1.000 51.48553 ? 54  TYR B CD1 1 
ATOM   2683 C CD2 . TYR B 1 54  ? -52.06964 -16.46325 30.65390  1.000 49.67037 ? 54  TYR B CD2 1 
ATOM   2684 C CE1 . TYR B 1 54  ? -49.43296 -16.79361 31.39825  1.000 50.14008 ? 54  TYR B CE1 1 
ATOM   2685 C CE2 . TYR B 1 54  ? -51.19448 -17.15046 29.82755  1.000 50.86718 ? 54  TYR B CE2 1 
ATOM   2686 C CZ  . TYR B 1 54  ? -49.87799 -17.31024 30.20653  1.000 50.15360 ? 54  TYR B CZ  1 
ATOM   2687 O OH  . TYR B 1 54  ? -49.00817 -17.99455 29.38650  1.000 54.09963 ? 54  TYR B OH  1 
ATOM   2688 N N   . GLU B 1 55  ? -54.94886 -14.57958 34.87757  1.000 54.71997 ? 55  GLU B N   1 
ATOM   2689 C CA  . GLU B 1 55  ? -55.51397 -13.70822 35.90110  1.000 58.53245 ? 55  GLU B CA  1 
ATOM   2690 C C   . GLU B 1 55  ? -55.49674 -14.39151 37.26165  1.000 55.91692 ? 55  GLU B C   1 
ATOM   2691 O O   . GLU B 1 55  ? -55.26708 -13.73082 38.28013  1.000 56.48917 ? 55  GLU B O   1 
ATOM   2692 C CB  . GLU B 1 55  ? -56.93277 -13.27768 35.52613  1.000 54.91545 ? 55  GLU B CB  1 
ATOM   2693 C CG  . GLU B 1 55  ? -57.10546 -12.90795 34.06399  1.000 62.28236 ? 55  GLU B CG  1 
ATOM   2694 C CD  . GLU B 1 55  ? -57.36100 -14.12641 33.18936  1.000 73.67442 ? 55  GLU B CD  1 
ATOM   2695 O OE1 . GLU B 1 55  ? -58.27608 -14.91917 33.52766  1.000 84.49961 ? 55  GLU B OE1 1 
ATOM   2696 O OE2 . GLU B 1 55  ? -56.64338 -14.30413 32.17848  1.000 70.95843 ? 55  GLU B OE2 1 
ATOM   2697 N N   . ASP B 1 56  ? -55.68775 -15.71591 37.28831  1.000 58.12465 ? 56  ASP B N   1 
ATOM   2698 C CA  . ASP B 1 56  ? -55.62640 -16.46946 38.53849  1.000 58.92208 ? 56  ASP B CA  1 
ATOM   2699 C C   . ASP B 1 56  ? -54.20092 -16.56363 39.05272  1.000 60.57186 ? 56  ASP B C   1 
ATOM   2700 O O   . ASP B 1 56  ? -53.93871 -16.31737 40.23761  1.000 58.49880 ? 56  ASP B O   1 
ATOM   2701 C CB  . ASP B 1 56  ? -56.19343 -17.87481 38.33854  1.000 63.88289 ? 56  ASP B CB  1 
ATOM   2702 C CG  . ASP B 1 56  ? -57.60343 -18.01828 38.86174  1.000 66.48182 ? 56  ASP B CG  1 
ATOM   2703 O OD1 . ASP B 1 56  ? -57.98193 -17.29167 39.80663  1.000 64.23982 ? 56  ASP B OD1 1 
ATOM   2704 O OD2 . ASP B 1 56  ? -58.33229 -18.87280 38.32176  1.000 73.54442 ? 56  ASP B OD2 1 
ATOM   2705 N N   . LEU B 1 57  ? -53.26735 -16.95023 38.17710  1.000 58.01438 ? 57  LEU B N   1 
ATOM   2706 C CA  . LEU B 1 57  ? -51.88571 -17.11313 38.60615  1.000 53.02782 ? 57  LEU B CA  1 
ATOM   2707 C C   . LEU B 1 57  ? -51.30104 -15.79731 39.07728  1.000 49.77785 ? 57  LEU B C   1 
ATOM   2708 O O   . LEU B 1 57  ? -50.40337 -15.78786 39.92371  1.000 49.12710 ? 57  LEU B O   1 
ATOM   2709 C CB  . LEU B 1 57  ? -51.04770 -17.69708 37.47087  1.000 54.85223 ? 57  LEU B CB  1 
ATOM   2710 C CG  . LEU B 1 57  ? -51.61553 -18.99929 36.90444  1.000 59.19279 ? 57  LEU B CG  1 
ATOM   2711 C CD1 . LEU B 1 57  ? -50.77361 -19.51940 35.76001  1.000 61.67515 ? 57  LEU B CD1 1 
ATOM   2712 C CD2 . LEU B 1 57  ? -51.70704 -20.04005 37.99984  1.000 60.98843 ? 57  LEU B CD2 1 
ATOM   2713 N N   . LEU B 1 58  ? -51.79956 -14.67826 38.54960  1.000 51.68069 ? 58  LEU B N   1 
ATOM   2714 C CA  . LEU B 1 58  ? -51.22604 -13.37814 38.87831  1.000 52.38411 ? 58  LEU B CA  1 
ATOM   2715 C C   . LEU B 1 58  ? -51.78296 -12.83630 40.18710  1.000 52.12427 ? 58  LEU B C   1 
ATOM   2716 O O   . LEU B 1 58  ? -51.05931 -12.18648 40.94700  1.000 52.02090 ? 58  LEU B O   1 
ATOM   2717 C CB  . LEU B 1 58  ? -51.48343 -12.37758 37.75178  1.000 45.77076 ? 58  LEU B CB  1 
ATOM   2718 C CG  . LEU B 1 58  ? -50.83775 -11.00008 37.95969  1.000 50.94321 ? 58  LEU B CG  1 
ATOM   2719 C CD1 . LEU B 1 58  ? -49.31073 -11.07203 37.99560  1.000 55.98556 ? 58  LEU B CD1 1 
ATOM   2720 C CD2 . LEU B 1 58  ? -51.29201 -10.02382 36.89041  1.000 53.26654 ? 58  LEU B CD2 1 
ATOM   2721 N N   . ILE B 1 59  ? -53.06855 -13.07602 40.46117  1.000 56.62465 ? 59  ILE B N   1 
ATOM   2722 C CA  . ILE B 1 59  ? -53.64480 -12.59332 41.71356  1.000 56.59890 ? 59  ILE B CA  1 
ATOM   2723 C C   . ILE B 1 59  ? -52.99650 -13.27474 42.91187  1.000 51.81259 ? 59  ILE B C   1 
ATOM   2724 O O   . ILE B 1 59  ? -52.98957 -12.71985 44.01549  1.000 59.49727 ? 59  ILE B O   1 
ATOM   2725 C CB  . ILE B 1 59  ? -55.17749 -12.77330 41.70083  1.000 55.16550 ? 59  ILE B CB  1 
ATOM   2726 C CG1 . ILE B 1 59  ? -55.83973 -11.70714 42.57606  1.000 59.71814 ? 59  ILE B CG1 1 
ATOM   2727 C CG2 . ILE B 1 59  ? -55.56885 -14.17645 42.15044  1.000 55.28090 ? 59  ILE B CG2 1 
ATOM   2728 C CD1 . ILE B 1 59  ? -57.35225 -11.75101 42.53644  1.000 58.72399 ? 59  ILE B CD1 1 
ATOM   2729 N N   . ARG B 1 60  ? -52.40201 -14.44313 42.70680  1.000 53.45081 ? 60  ARG B N   1 
ATOM   2730 C CA  . ARG B 1 60  ? -51.70895 -15.18620 43.74804  1.000 52.56201 ? 60  ARG B CA  1 
ATOM   2731 C C   . ARG B 1 60  ? -50.24477 -14.79180 43.89254  1.000 56.28565 ? 60  ARG B C   1 
ATOM   2732 O O   . ARG B 1 60  ? -49.49328 -15.49909 44.57012  1.000 56.46302 ? 60  ARG B O   1 
ATOM   2733 C CB  . ARG B 1 60  ? -51.81509 -16.68825 43.46355  1.000 50.12557 ? 60  ARG B CB  1 
ATOM   2734 C CG  . ARG B 1 60  ? -53.22235 -17.13561 43.17358  1.000 50.25974 ? 60  ARG B CG  1 
ATOM   2735 C CD  . ARG B 1 60  ? -53.29747 -18.59891 42.78747  1.000 52.38921 ? 60  ARG B CD  1 
ATOM   2736 N NE  . ARG B 1 60  ? -54.63317 -19.11973 43.04533  1.000 59.18276 ? 60  ARG B NE  1 
ATOM   2737 C CZ  . ARG B 1 60  ? -55.41696 -19.69915 42.14728  1.000 62.78439 ? 60  ARG B CZ  1 
ATOM   2738 N NH1 . ARG B 1 60  ? -55.01506 -19.89800 40.90130  1.000 69.59286 ? 60  ARG B NH1 1 
ATOM   2739 N NH2 . ARG B 1 60  ? -56.63041 -20.10562 42.51539  1.000 63.32999 ? 60  ARG B NH2 1 
ATOM   2740 N N   . LYS B 1 61  ? -49.81698 -13.69089 43.27448  1.000 56.68339 ? 61  LYS B N   1 
ATOM   2741 C CA  . LYS B 1 61  ? -48.42522 -13.26291 43.30496  1.000 56.92286 ? 61  LYS B CA  1 
ATOM   2742 C C   . LYS B 1 61  ? -48.31541 -11.88276 43.94255  1.000 59.00888 ? 61  LYS B C   1 
ATOM   2743 O O   . LYS B 1 61  ? -49.23504 -11.06169 43.84910  1.000 57.82188 ? 61  LYS B O   1 
ATOM   2744 C CB  . LYS B 1 61  ? -47.81355 -13.21683 41.88082  1.000 58.87638 ? 61  LYS B CB  1 
ATOM   2745 C CG  . LYS B 1 61  ? -47.72074 -14.55879 41.16535  1.000 58.03430 ? 61  LYS B CG  1 
ATOM   2746 C CD  . LYS B 1 61  ? -46.31338 -15.12507 41.23249  1.000 56.39137 ? 61  LYS B CD  1 
ATOM   2747 C CE  . LYS B 1 61  ? -46.23447 -16.50625 40.59992  1.000 57.79495 ? 61  LYS B CE  1 
ATOM   2748 N NZ  . LYS B 1 61  ? -45.12780 -17.28602 41.21430  1.000 57.73358 ? 61  LYS B NZ  1 
ATOM   2749 N N   . SER B 1 62  ? -47.17769 -11.62196 44.58048  1.000 61.64004 ? 62  SER B N   1 
ATOM   2750 C CA  . SER B 1 62  ? -46.85949 -10.28582 45.06866  1.000 65.64224 ? 62  SER B CA  1 
ATOM   2751 C C   . SER B 1 62  ? -45.52929 -9.81088  44.48477  1.000 68.86924 ? 62  SER B C   1 
ATOM   2752 O O   . SER B 1 62  ? -44.75885 -10.58975 43.91112  1.000 65.95335 ? 62  SER B O   1 
ATOM   2753 C CB  . SER B 1 62  ? -46.82067 -10.25051 46.60153  1.000 67.31403 ? 62  SER B CB  1 
ATOM   2754 O OG  . SER B 1 62  ? -45.99014 -11.27635 47.10998  1.000 73.13750 ? 62  SER B OG  1 
ATOM   2755 N N   . ASN B 1 63  ? -45.27271 -8.50499  44.64081  1.000 65.35831 ? 63  ASN B N   1 
ATOM   2756 C CA  . ASN B 1 63  ? -44.04978 -7.89132  44.12976  1.000 66.74556 ? 63  ASN B CA  1 
ATOM   2757 C C   . ASN B 1 63  ? -42.81253 -8.75188  44.39278  1.000 70.38602 ? 63  ASN B C   1 
ATOM   2758 O O   . ASN B 1 63  ? -42.02645 -9.02773  43.47872  1.000 67.91308 ? 63  ASN B O   1 
ATOM   2759 C CB  . ASN B 1 63  ? -43.87124 -6.49557  44.74155  1.000 70.44338 ? 63  ASN B CB  1 
ATOM   2760 C CG  . ASN B 1 63  ? -44.90649 -5.48971  44.24310  1.000 71.90115 ? 63  ASN B CG  1 
ATOM   2761 O OD1 . ASN B 1 63  ? -45.56081 -5.69949  43.22033  1.000 69.42632 ? 63  ASN B OD1 1 
ATOM   2762 N ND2 . ASN B 1 63  ? -45.04045 -4.37820  44.96085  1.000 73.37825 ? 63  ASN B ND2 1 
ATOM   2763 N N   . HIS B 1 64  ? -42.63135 -9.20202  45.63645  1.000 70.27001 ? 64  HIS B N   1 
ATOM   2764 C CA  . HIS B 1 64  ? -41.43929 -9.95879  46.01166  1.000 65.17934 ? 64  HIS B CA  1 
ATOM   2765 C C   . HIS B 1 64  ? -41.31935 -11.30469 45.30115  1.000 65.36417 ? 64  HIS B C   1 
ATOM   2766 O O   . HIS B 1 64  ? -40.31574 -11.99519 45.51615  1.000 66.52653 ? 64  HIS B O   1 
ATOM   2767 C CB  . HIS B 1 64  ? -41.40199 -10.16918 47.53142  1.000 65.82412 ? 64  HIS B CB  1 
ATOM   2768 C CG  . HIS B 1 64  ? -42.25268 -11.30464 48.01252  1.000 68.09329 ? 64  HIS B CG  1 
ATOM   2769 N ND1 . HIS B 1 64  ? -43.50109 -11.12123 48.56998  1.000 68.77136 ? 64  HIS B ND1 1 
ATOM   2770 C CD2 . HIS B 1 64  ? -42.02995 -12.64071 48.01987  1.000 65.76486 ? 64  HIS B CD2 1 
ATOM   2771 C CE1 . HIS B 1 64  ? -44.01027 -12.29551 48.89759  1.000 68.37451 ? 64  HIS B CE1 1 
ATOM   2772 N NE2 . HIS B 1 64  ? -43.13879 -13.23388 48.57136  1.000 71.13046 ? 64  HIS B NE2 1 
ATOM   2773 N N   . ASN B 1 65  ? -42.28981 -11.70469 44.47624  1.000 66.49152 ? 65  ASN B N   1 
ATOM   2774 C CA  . ASN B 1 65  ? -42.16396 -12.93671 43.70106  1.000 67.37209 ? 65  ASN B CA  1 
ATOM   2775 C C   . ASN B 1 65  ? -41.40639 -12.74647 42.38677  1.000 65.53684 ? 65  ASN B C   1 
ATOM   2776 O O   . ASN B 1 65  ? -41.18510 -13.73869 41.68103  1.000 63.39280 ? 65  ASN B O   1 
ATOM   2777 C CB  . ASN B 1 65  ? -43.54687 -13.52821 43.40359  1.000 65.09065 ? 65  ASN B CB  1 
ATOM   2778 C CG  . ASN B 1 65  ? -44.21358 -14.11044 44.63314  1.000 65.81187 ? 65  ASN B CG  1 
ATOM   2779 O OD1 . ASN B 1 65  ? -45.33598 -13.74059 44.98104  1.000 64.28629 ? 65  ASN B OD1 1 
ATOM   2780 N ND2 . ASN B 1 65  ? -43.52710 -15.03052 45.29500  1.000 62.68580 ? 65  ASN B ND2 1 
ATOM   2781 N N   . PHE B 1 66  ? -41.00294 -11.51316 42.05040  1.000 63.64179 ? 66  PHE B N   1 
ATOM   2782 C CA  . PHE B 1 66  ? -40.33112 -11.18542 40.78935  1.000 62.24751 ? 66  PHE B CA  1 
ATOM   2783 C C   . PHE B 1 66  ? -38.92221 -10.67439 41.07178  1.000 62.16918 ? 66  PHE B C   1 
ATOM   2784 O O   . PHE B 1 66  ? -38.75489 -9.54264  41.53817  1.000 64.45185 ? 66  PHE B O   1 
ATOM   2785 C CB  . PHE B 1 66  ? -41.10704 -10.12263 40.00992  1.000 58.85664 ? 66  PHE B CB  1 
ATOM   2786 C CG  . PHE B 1 66  ? -42.50712 -10.51463 39.66276  1.000 59.20224 ? 66  PHE B CG  1 
ATOM   2787 C CD1 . PHE B 1 66  ? -42.75191 -11.48582 38.70332  1.000 59.97412 ? 66  PHE B CD1 1 
ATOM   2788 C CD2 . PHE B 1 66  ? -43.58640 -9.89522  40.27929  1.000 59.73849 ? 66  PHE B CD2 1 
ATOM   2789 C CE1 . PHE B 1 66  ? -44.05228 -11.84640 38.37636  1.000 61.83534 ? 66  PHE B CE1 1 
ATOM   2790 C CE2 . PHE B 1 66  ? -44.88073 -10.24569 39.96146  1.000 62.56196 ? 66  PHE B CE2 1 
ATOM   2791 C CZ  . PHE B 1 66  ? -45.11898 -11.22634 39.00800  1.000 62.84079 ? 66  PHE B CZ  1 
ATOM   2792 N N   . LEU B 1 67  ? -37.90837 -11.48114 40.75709  1.000 61.28084 ? 67  LEU B N   1 
ATOM   2793 C CA  . LEU B 1 67  ? -36.51675 -11.05727 40.88642  1.000 61.06009 ? 67  LEU B CA  1 
ATOM   2794 C C   . LEU B 1 67  ? -36.07813 -10.41376 39.57299  1.000 64.52047 ? 67  LEU B C   1 
ATOM   2795 O O   . LEU B 1 67  ? -35.97063 -11.09233 38.54622  1.000 63.88855 ? 67  LEU B O   1 
ATOM   2796 C CB  . LEU B 1 67  ? -35.61317 -12.23629 41.24119  1.000 60.08267 ? 67  LEU B CB  1 
ATOM   2797 N N   . VAL B 1 68  ? -35.81291 -9.11247  39.60400  1.000 61.75012 ? 68  VAL B N   1 
ATOM   2798 C CA  . VAL B 1 68  ? -35.33658 -8.37895  38.43970  1.000 63.16684 ? 68  VAL B CA  1 
ATOM   2799 C C   . VAL B 1 68  ? -33.87174 -8.03787  38.66589  1.000 64.63249 ? 68  VAL B C   1 
ATOM   2800 O O   . VAL B 1 68  ? -33.52593 -7.38457  39.65679  1.000 68.78726 ? 68  VAL B O   1 
ATOM   2801 C CB  . VAL B 1 68  ? -36.17599 -7.11874  38.18808  1.000 62.11376 ? 68  VAL B CB  1 
ATOM   2802 C CG1 . VAL B 1 68  ? -35.57240 -6.29261  37.07292  1.000 64.69395 ? 68  VAL B CG1 1 
ATOM   2803 C CG2 . VAL B 1 68  ? -37.60415 -7.51735  37.84687  1.000 57.95490 ? 68  VAL B CG2 1 
ATOM   2804 N N   . GLN B 1 69  ? -33.01011 -8.47468  37.75070  1.000 64.76202 ? 69  GLN B N   1 
ATOM   2805 C CA  . GLN B 1 69  ? -31.57198 -8.25200  37.85295  1.000 62.23682 ? 69  GLN B CA  1 
ATOM   2806 C C   . GLN B 1 69  ? -31.11798 -7.38748  36.68572  1.000 65.61053 ? 69  GLN B C   1 
ATOM   2807 O O   . GLN B 1 69  ? -31.30733 -7.75915  35.52342  1.000 66.07626 ? 69  GLN B O   1 
ATOM   2808 C CB  . GLN B 1 69  ? -30.81244 -9.57978  37.86723  1.000 64.07651 ? 69  GLN B CB  1 
ATOM   2809 C CG  . GLN B 1 69  ? -29.53122 -9.56454  38.69102  1.000 68.61596 ? 69  GLN B CG  1 
ATOM   2810 N N   . ALA B 1 70  ? -30.53062 -6.23526  36.99304  1.000 66.39550 ? 70  ALA B N   1 
ATOM   2811 C CA  . ALA B 1 70  ? -29.94494 -5.34863  35.98762  1.000 65.03598 ? 70  ALA B CA  1 
ATOM   2812 C C   . ALA B 1 70  ? -28.43046 -5.49475  36.08456  1.000 68.30628 ? 70  ALA B C   1 
ATOM   2813 O O   . ALA B 1 70  ? -27.76716 -4.79485  36.85027  1.000 67.78395 ? 70  ALA B O   1 
ATOM   2814 C CB  . ALA B 1 70  ? -30.38702 -3.90593  36.19974  1.000 61.31464 ? 70  ALA B CB  1 
ATOM   2815 N N   . GLY B 1 71  ? -27.88293 -6.41737  35.29710  1.000 69.56668 ? 71  GLY B N   1 
ATOM   2816 C CA  . GLY B 1 71  ? -26.48532 -6.77180  35.42877  1.000 69.29756 ? 71  GLY B CA  1 
ATOM   2817 C C   . GLY B 1 71  ? -26.26441 -7.48921  36.74127  1.000 74.69468 ? 71  GLY B C   1 
ATOM   2818 O O   . GLY B 1 71  ? -26.64687 -8.65571  36.88916  1.000 74.24304 ? 71  GLY B O   1 
ATOM   2819 N N   . ASN B 1 72  ? -25.66553 -6.79304  37.70899  1.000 79.14674 ? 72  ASN B N   1 
ATOM   2820 C CA  . ASN B 1 72  ? -25.62437 -7.26093  39.09026  1.000 79.35599 ? 72  ASN B CA  1 
ATOM   2821 C C   . ASN B 1 72  ? -26.66385 -6.58053  39.97274  1.000 77.51070 ? 72  ASN B C   1 
ATOM   2822 O O   . ASN B 1 72  ? -27.17603 -7.20836  40.90647  1.000 78.70305 ? 72  ASN B O   1 
ATOM   2823 C CB  . ASN B 1 72  ? -24.22882 -7.04247  39.68968  1.000 72.19305 ? 72  ASN B CB  1 
ATOM   2824 N N   . VAL B 1 73  ? -27.00272 -5.32450  39.67211  1.000 72.37757 ? 73  VAL B N   1 
ATOM   2825 C CA  . VAL B 1 73  ? -27.95394 -4.56130  40.47262  1.000 69.76901 ? 73  VAL B CA  1 
ATOM   2826 C C   . VAL B 1 73  ? -29.32456 -5.21889  40.41267  1.000 71.20665 ? 73  VAL B C   1 
ATOM   2827 O O   . VAL B 1 73  ? -29.95225 -5.28429  39.34973  1.000 72.20305 ? 73  VAL B O   1 
ATOM   2828 C CB  . VAL B 1 73  ? -28.01839 -3.11236  39.97812  1.000 73.96188 ? 73  VAL B CB  1 
ATOM   2829 C CG1 . VAL B 1 73  ? -29.06385 -2.32766  40.76376  1.000 78.39039 ? 73  VAL B CG1 1 
ATOM   2830 C CG2 . VAL B 1 73  ? -26.64150 -2.45478  40.06208  1.000 67.92755 ? 73  VAL B CG2 1 
ATOM   2831 N N   . GLN B 1 74  ? -29.80768 -5.69503  41.55640  1.000 75.79867 ? 74  GLN B N   1 
ATOM   2832 C CA  . GLN B 1 74  ? -31.16356 -6.22348  41.63726  1.000 71.60097 ? 74  GLN B CA  1 
ATOM   2833 C C   . GLN B 1 74  ? -32.13381 -5.05919  41.80706  1.000 72.69004 ? 74  GLN B C   1 
ATOM   2834 O O   . GLN B 1 74  ? -31.99713 -4.25999  42.73881  1.000 76.18567 ? 74  GLN B O   1 
ATOM   2835 C CB  . GLN B 1 74  ? -31.28998 -7.21893  42.79062  1.000 70.02927 ? 74  GLN B CB  1 
ATOM   2836 N N   . LEU B 1 75  ? -33.09702 -4.94808  40.90148  1.000 71.61899 ? 75  LEU B N   1 
ATOM   2837 C CA  . LEU B 1 75  ? -34.10989 -3.90855  40.98868  1.000 70.89795 ? 75  LEU B CA  1 
ATOM   2838 C C   . LEU B 1 75  ? -35.27591 -4.38208  41.84563  1.000 74.57155 ? 75  LEU B C   1 
ATOM   2839 O O   . LEU B 1 75  ? -35.62730 -5.56649  41.85272  1.000 71.50817 ? 75  LEU B O   1 
ATOM   2840 C CB  . LEU B 1 75  ? -34.60896 -3.52336  39.59712  1.000 67.12270 ? 75  LEU B CB  1 
ATOM   2841 C CG  . LEU B 1 75  ? -33.50854 -3.08037  38.62954  1.000 72.10569 ? 75  LEU B CG  1 
ATOM   2842 C CD1 . LEU B 1 75  ? -34.10204 -2.69304  37.28567  1.000 68.30744 ? 75  LEU B CD1 1 
ATOM   2843 C CD2 . LEU B 1 75  ? -32.69635 -1.92516  39.21728  1.000 70.72468 ? 75  LEU B CD2 1 
ATOM   2844 N N   . ARG B 1 76  ? -35.87911 -3.43872  42.56769  1.000 76.41930 ? 76  ARG B N   1 
ATOM   2845 C CA  . ARG B 1 76  ? -36.99676 -3.73682  43.45498  1.000 75.12495 ? 76  ARG B CA  1 
ATOM   2846 C C   . ARG B 1 76  ? -38.31624 -3.56215  42.71508  1.000 71.33679 ? 76  ARG B C   1 
ATOM   2847 O O   . ARG B 1 76  ? -38.57896 -2.50116  42.13936  1.000 70.64329 ? 76  ARG B O   1 
ATOM   2848 C CB  . ARG B 1 76  ? -36.96553 -2.83364  44.69080  1.000 78.23589 ? 76  ARG B CB  1 
ATOM   2849 N N   . VAL B 1 77  ? -39.14068 -4.60338  42.73450  1.000 72.09369 ? 77  VAL B N   1 
ATOM   2850 C CA  . VAL B 1 77  ? -40.46400 -4.54852  42.11969  1.000 74.63039 ? 77  VAL B CA  1 
ATOM   2851 C C   . VAL B 1 77  ? -41.44863 -3.94508  43.12006  1.000 74.43993 ? 77  VAL B C   1 
ATOM   2852 O O   . VAL B 1 77  ? -41.69202 -4.51757  44.18807  1.000 77.13932 ? 77  VAL B O   1 
ATOM   2853 C CB  . VAL B 1 77  ? -40.91494 -5.94479  41.66547  1.000 68.52140 ? 77  VAL B CB  1 
ATOM   2854 C CG1 . VAL B 1 77  ? -42.28682 -5.87398  41.00793  1.000 67.11057 ? 77  VAL B CG1 1 
ATOM   2855 C CG2 . VAL B 1 77  ? -39.87696 -6.55667  40.71763  1.000 69.37523 ? 77  VAL B CG2 1 
ATOM   2856 N N   . ILE B 1 78  ? -42.02554 -2.79221  42.77136  1.000 70.88004 ? 78  ILE B N   1 
ATOM   2857 C CA  . ILE B 1 78  ? -42.91086 -2.05770  43.67425  1.000 72.06408 ? 78  ILE B CA  1 
ATOM   2858 C C   . ILE B 1 78  ? -44.29797 -1.90820  43.06346  1.000 72.72079 ? 78  ILE B C   1 
ATOM   2859 O O   . ILE B 1 78  ? -45.03416 -0.96363  43.37656  1.000 73.99833 ? 78  ILE B O   1 
ATOM   2860 C CB  . ILE B 1 78  ? -42.32844 -0.67616  44.00869  1.000 70.48192 ? 78  ILE B CB  1 
ATOM   2861 C CG1 . ILE B 1 78  ? -42.39575 0.22522   42.77633  1.000 70.95761 ? 78  ILE B CG1 1 
ATOM   2862 C CG2 . ILE B 1 78  ? -40.90127 -0.81606  44.51088  1.000 73.17345 ? 78  ILE B CG2 1 
ATOM   2863 C CD1 . ILE B 1 78  ? -41.56058 1.48173   42.90024  1.000 71.32221 ? 78  ILE B CD1 1 
ATOM   2864 N N   . GLY B 1 79  ? -44.66018 -2.83087  42.19348  1.000 68.61641 ? 79  GLY B N   1 
ATOM   2865 C CA  . GLY B 1 79  ? -45.91525 -2.75296  41.48107  1.000 64.49606 ? 79  GLY B CA  1 
ATOM   2866 C C   . GLY B 1 79  ? -45.92488 -3.73074  40.33772  1.000 64.81399 ? 79  GLY B C   1 
ATOM   2867 O O   . GLY B 1 79  ? -44.88660 -4.20680  39.87450  1.000 66.28465 ? 79  GLY B O   1 
ATOM   2868 N N   . HIS B 1 80  ? -47.12906 -4.06626  39.89155  1.000 64.55007 ? 80  HIS B N   1 
ATOM   2869 C CA  . HIS B 1 80  ? -47.23890 -4.92179  38.72247  1.000 60.12860 ? 80  HIS B CA  1 
ATOM   2870 C C   . HIS B 1 80  ? -48.66287 -4.86905  38.20523  1.000 60.45439 ? 80  HIS B C   1 
ATOM   2871 O O   . HIS B 1 80  ? -49.60271 -4.55192  38.93883  1.000 58.80429 ? 80  HIS B O   1 
ATOM   2872 C CB  . HIS B 1 80  ? -46.79655 -6.36627  39.01431  1.000 57.69704 ? 80  HIS B CB  1 
ATOM   2873 C CG  . HIS B 1 80  ? -47.64411 -7.09439  40.01792  1.000 65.80685 ? 80  HIS B CG  1 
ATOM   2874 N ND1 . HIS B 1 80  ? -47.29992 -7.19766  41.34995  1.000 64.74791 ? 80  HIS B ND1 1 
ATOM   2875 C CD2 . HIS B 1 80  ? -48.78838 -7.80491  39.87307  1.000 64.68358 ? 80  HIS B CD2 1 
ATOM   2876 C CE1 . HIS B 1 80  ? -48.20797 -7.91556  41.98682  1.000 66.41553 ? 80  HIS B CE1 1 
ATOM   2877 N NE2 . HIS B 1 80  ? -49.12105 -8.29972  41.11301  1.000 67.19674 ? 80  HIS B NE2 1 
ATOM   2878 N N   . SER B 1 81  ? -48.79273 -5.14169  36.91095  1.000 55.88039 ? 81  SER B N   1 
ATOM   2879 C CA  . SER B 1 81  ? -50.07951 -5.27843  36.24650  1.000 56.02139 ? 81  SER B CA  1 
ATOM   2880 C C   . SER B 1 81  ? -49.89231 -6.19089  35.04448  1.000 57.38356 ? 81  SER B C   1 
ATOM   2881 O O   . SER B 1 81  ? -48.78762 -6.66223  34.75611  1.000 63.15725 ? 81  SER B O   1 
ATOM   2882 C CB  . SER B 1 81  ? -50.64539 -3.92615  35.81828  1.000 51.42544 ? 81  SER B CB  1 
ATOM   2883 O OG  . SER B 1 81  ? -49.72129 -3.22928  35.00483  1.000 55.71652 ? 81  SER B OG  1 
ATOM   2884 N N   . MET B 1 82  ? -50.97786 -6.42134  34.32556  1.000 52.61075 ? 82  MET B N   1 
ATOM   2885 C CA  . MET B 1 82  ? -50.95203 -7.24894  33.13452  1.000 51.01324 ? 82  MET B CA  1 
ATOM   2886 C C   . MET B 1 82  ? -51.70840 -6.51447  32.04478  1.000 53.49351 ? 82  MET B C   1 
ATOM   2887 O O   . MET B 1 82  ? -52.86951 -6.13787  32.23690  1.000 55.43310 ? 82  MET B O   1 
ATOM   2888 C CB  . MET B 1 82  ? -51.58053 -8.61105  33.39176  1.000 51.64314 ? 82  MET B CB  1 
ATOM   2889 C CG  . MET B 1 82  ? -50.98837 -9.70460  32.55951  1.000 53.41159 ? 82  MET B CG  1 
ATOM   2890 S SD  . MET B 1 82  ? -52.06553 -11.11896 32.45219  1.000 57.62076 ? 82  MET B SD  1 
ATOM   2891 C CE  . MET B 1 82  ? -53.36118 -10.47176 31.38262  1.000 56.79434 ? 82  MET B CE  1 
ATOM   2892 N N   . GLN B 1 83  ? -51.05041 -6.30171  30.91312  1.000 50.85139 ? 83  GLN B N   1 
ATOM   2893 C CA  . GLN B 1 83  ? -51.67590 -5.71140  29.73717  1.000 48.23754 ? 83  GLN B CA  1 
ATOM   2894 C C   . GLN B 1 83  ? -51.60857 -6.77829  28.66157  1.000 47.30761 ? 83  GLN B C   1 
ATOM   2895 O O   . GLN B 1 83  ? -50.52077 -7.11075  28.18176  1.000 48.12534 ? 83  GLN B O   1 
ATOM   2896 C CB  . GLN B 1 83  ? -50.97942 -4.41680  29.31223  1.000 46.95410 ? 83  GLN B CB  1 
ATOM   2897 C CG  . GLN B 1 83  ? -51.70947 -3.68159  28.18236  1.000 47.33433 ? 83  GLN B CG  1 
ATOM   2898 C CD  . GLN B 1 83  ? -50.96299 -2.46011  27.66468  1.000 48.42736 ? 83  GLN B CD  1 
ATOM   2899 O OE1 . GLN B 1 83  ? -49.85843 -2.14656  28.10958  1.000 46.95017 ? 83  GLN B OE1 1 
ATOM   2900 N NE2 . GLN B 1 83  ? -51.57163 -1.76471  26.71566  1.000 47.94850 ? 83  GLN B NE2 1 
ATOM   2901 N N   . ASN B 1 84  ? -52.76180 -7.35807  28.34239  1.000 48.62111 ? 84  ASN B N   1 
ATOM   2902 C CA  . ASN B 1 84  ? -52.85239 -8.48648  27.42746  1.000 46.89407 ? 84  ASN B CA  1 
ATOM   2903 C C   . ASN B 1 84  ? -51.80868 -9.54092  27.77567  1.000 51.45646 ? 84  ASN B C   1 
ATOM   2904 O O   . ASN B 1 84  ? -51.85541 -10.10595 28.87438  1.000 50.39851 ? 84  ASN B O   1 
ATOM   2905 C CB  . ASN B 1 84  ? -52.73473 -7.98388  25.99540  1.000 46.72872 ? 84  ASN B CB  1 
ATOM   2906 C CG  . ASN B 1 84  ? -53.81340 -6.95942  25.66633  1.000 46.25191 ? 84  ASN B CG  1 
ATOM   2907 O OD1 . ASN B 1 84  ? -54.98737 -7.30090  25.54207  1.000 46.73613 ? 84  ASN B OD1 1 
ATOM   2908 N ND2 . ASN B 1 84  ? -53.42137 -5.69848  25.54472  1.000 48.64821 ? 84  ASN B ND2 1 
ATOM   2909 N N   . CYS B 1 85  ? -50.85668 -9.82478  26.88737  1.000 44.50717 ? 85  CYS B N   1 
ATOM   2910 C CA  . CYS B 1 85  ? -49.91758 -10.90804 27.15549  1.000 43.94233 ? 85  CYS B CA  1 
ATOM   2911 C C   . CYS B 1 85  ? -48.59370 -10.44484 27.75136  1.000 44.16054 ? 85  CYS B C   1 
ATOM   2912 O O   . CYS B 1 85  ? -47.68252 -11.26110 27.90608  1.000 45.72865 ? 85  CYS B O   1 
ATOM   2913 C CB  . CYS B 1 85  ? -49.66000 -11.72259 25.89170  1.000 42.53053 ? 85  CYS B CB  1 
ATOM   2914 S SG  . CYS B 1 85  ? -51.09891 -12.57060 25.27265  1.000 46.81415 ? 85  CYS B SG  1 
ATOM   2915 N N   . VAL B 1 86  ? -48.45420 -9.17869  28.11743  1.000 46.21196 ? 86  VAL B N   1 
ATOM   2916 C CA  . VAL B 1 86  ? -47.21705 -8.74948  28.75561  1.000 46.04029 ? 86  VAL B CA  1 
ATOM   2917 C C   . VAL B 1 86  ? -47.48229 -8.42008  30.21749  1.000 50.58075 ? 86  VAL B C   1 
ATOM   2918 O O   . VAL B 1 86  ? -48.56286 -7.95867  30.60025  1.000 50.52432 ? 86  VAL B O   1 
ATOM   2919 C CB  . VAL B 1 86  ? -46.53601 -7.55207  28.05795  1.000 43.59388 ? 86  VAL B CB  1 
ATOM   2920 C CG1 . VAL B 1 86  ? -46.22405 -7.89694  26.59052  1.000 46.30474 ? 86  VAL B CG1 1 
ATOM   2921 C CG2 . VAL B 1 86  ? -47.37166 -6.29604  28.18969  1.000 40.54950 ? 86  VAL B CG2 1 
ATOM   2922 N N   . LEU B 1 87  ? -46.46746 -8.68114  31.02976  1.000 50.98035 ? 87  LEU B N   1 
ATOM   2923 C CA  . LEU B 1 87  ? -46.34165 -8.17444  32.38298  1.000 48.85914 ? 87  LEU B CA  1 
ATOM   2924 C C   . LEU B 1 87  ? -45.60445 -6.84087  32.38089  1.000 51.92977 ? 87  LEU B C   1 
ATOM   2925 O O   . LEU B 1 87  ? -44.58433 -6.68262  31.69866  1.000 54.07949 ? 87  LEU B O   1 
ATOM   2926 C CB  . LEU B 1 87  ? -45.55591 -9.17656  33.21499  1.000 49.87381 ? 87  LEU B CB  1 
ATOM   2927 C CG  . LEU B 1 87  ? -46.09728 -9.49422  34.58323  1.000 59.80932 ? 87  LEU B CG  1 
ATOM   2928 C CD1 . LEU B 1 87  ? -47.55852 -9.83974  34.40786  1.000 60.54274 ? 87  LEU B CD1 1 
ATOM   2929 C CD2 . LEU B 1 87  ? -45.30223 -10.66373 35.14634  1.000 59.54552 ? 87  LEU B CD2 1 
ATOM   2930 N N   . LYS B 1 88  ? -46.11191 -5.89012  33.16134  1.000 51.48117 ? 88  LYS B N   1 
ATOM   2931 C CA  . LYS B 1 88  ? -45.45966 -4.60663  33.40310  1.000 47.66194 ? 88  LYS B CA  1 
ATOM   2932 C C   . LYS B 1 88  ? -45.12296 -4.51949  34.88639  1.000 55.97902 ? 88  LYS B C   1 
ATOM   2933 O O   . LYS B 1 88  ? -46.02676 -4.46212  35.73174  1.000 60.21752 ? 88  LYS B O   1 
ATOM   2934 C CB  . LYS B 1 88  ? -46.35414 -3.44306  32.97307  1.000 49.63865 ? 88  LYS B CB  1 
ATOM   2935 C CG  . LYS B 1 88  ? -46.75552 -3.49901  31.50835  1.000 51.64379 ? 88  LYS B CG  1 
ATOM   2936 C CD  . LYS B 1 88  ? -47.40877 -2.21502  31.03741  1.000 51.53758 ? 88  LYS B CD  1 
ATOM   2937 C CE  . LYS B 1 88  ? -48.78184 -2.06791  31.61630  1.000 50.72295 ? 88  LYS B CE  1 
ATOM   2938 N NZ  . LYS B 1 88  ? -49.60713 -1.15135  30.79486  1.000 51.98704 ? 88  LYS B NZ  1 
ATOM   2939 N N   . LEU B 1 89  ? -43.82960 -4.50822  35.19759  1.000 53.36673 ? 89  LEU B N   1 
ATOM   2940 C CA  . LEU B 1 89  ? -43.32300 -4.50807  36.56715  1.000 58.03160 ? 89  LEU B CA  1 
ATOM   2941 C C   . LEU B 1 89  ? -42.82099 -3.11032  36.91369  1.000 62.38878 ? 89  LEU B C   1 
ATOM   2942 O O   . LEU B 1 89  ? -41.80818 -2.65730  36.36482  1.000 61.51418 ? 89  LEU B O   1 
ATOM   2943 C CB  . LEU B 1 89  ? -42.20972 -5.54346  36.71891  1.000 58.53648 ? 89  LEU B CB  1 
ATOM   2944 C CG  . LEU B 1 89  ? -42.60318 -6.97683  36.33691  1.000 52.11876 ? 89  LEU B CG  1 
ATOM   2945 C CD1 . LEU B 1 89  ? -41.44287 -7.94711  36.50598  1.000 55.68635 ? 89  LEU B CD1 1 
ATOM   2946 C CD2 . LEU B 1 89  ? -43.77898 -7.42083  37.16371  1.000 56.38684 ? 89  LEU B CD2 1 
ATOM   2947 N N   . LYS B 1 90  ? -43.52804 -2.42350  37.81452  1.000 62.20933 ? 90  LYS B N   1 
ATOM   2948 C CA  . LYS B 1 90  ? -43.04823 -1.13674  38.30365  1.000 61.87587 ? 90  LYS B CA  1 
ATOM   2949 C C   . LYS B 1 90  ? -41.87371 -1.36405  39.24768  1.000 66.73667 ? 90  LYS B C   1 
ATOM   2950 O O   . LYS B 1 90  ? -41.94610 -2.20155  40.15252  1.000 69.05833 ? 90  LYS B O   1 
ATOM   2951 C CB  . LYS B 1 90  ? -44.16677 -0.37663  39.01338  1.000 64.45571 ? 90  LYS B CB  1 
ATOM   2952 C CG  . LYS B 1 90  ? -43.79556 1.04020   39.43720  1.000 66.67206 ? 90  LYS B CG  1 
ATOM   2953 C CD  . LYS B 1 90  ? -44.10643 2.05148   38.33779  1.000 67.64319 ? 90  LYS B CD  1 
ATOM   2954 N N   . VAL B 1 91  ? -40.78330 -0.62674  39.03059  1.000 66.45466 ? 91  VAL B N   1 
ATOM   2955 C CA  . VAL B 1 91  ? -39.55896 -0.80762  39.79660  1.000 70.14117 ? 91  VAL B CA  1 
ATOM   2956 C C   . VAL B 1 91  ? -39.14227 0.52701   40.40319  1.000 69.45619 ? 91  VAL B C   1 
ATOM   2957 O O   . VAL B 1 91  ? -39.59901 1.59737   39.99110  1.000 71.56614 ? 91  VAL B O   1 
ATOM   2958 C CB  . VAL B 1 91  ? -38.42124 -1.39640  38.93521  1.000 68.57877 ? 91  VAL B CB  1 
ATOM   2959 C CG1 . VAL B 1 91  ? -38.73171 -2.84227  38.57179  1.000 62.69173 ? 91  VAL B CG1 1 
ATOM   2960 C CG2 . VAL B 1 91  ? -38.22612 -0.56178  37.68278  1.000 63.89890 ? 91  VAL B CG2 1 
ATOM   2961 N N   . ASP B 1 92  ? -38.25127 0.44771   41.39849  1.000 70.04816 ? 92  ASP B N   1 
ATOM   2962 C CA  . ASP B 1 92  ? -37.89734 1.62484   42.18789  1.000 73.18754 ? 92  ASP B CA  1 
ATOM   2963 C C   . ASP B 1 92  ? -36.96737 2.57136   41.44029  1.000 72.85470 ? 92  ASP B C   1 
ATOM   2964 O O   . ASP B 1 92  ? -37.03131 3.78737   41.65238  1.000 76.48337 ? 92  ASP B O   1 
ATOM   2965 C CB  . ASP B 1 92  ? -37.26175 1.19863   43.51645  1.000 75.55383 ? 92  ASP B CB  1 
ATOM   2966 C CG  . ASP B 1 92  ? -36.13933 0.18698   43.33649  1.000 78.32284 ? 92  ASP B CG  1 
ATOM   2967 O OD1 . ASP B 1 92  ? -35.79743 -0.13739  42.17766  1.000 79.24049 ? 92  ASP B OD1 1 
ATOM   2968 O OD2 . ASP B 1 92  ? -35.60078 -0.29015  44.35970  1.000 80.93885 ? 92  ASP B OD2 1 
ATOM   2969 N N   . THR B 1 93  ? -36.11471 2.04376   40.56743  1.000 73.08371 ? 93  THR B N   1 
ATOM   2970 C CA  . THR B 1 93  ? -35.16706 2.83746   39.79742  1.000 67.52606 ? 93  THR B CA  1 
ATOM   2971 C C   . THR B 1 93  ? -35.69395 3.05762   38.38581  1.000 68.26171 ? 93  THR B C   1 
ATOM   2972 O O   . THR B 1 93  ? -36.15978 2.11651   37.73663  1.000 66.54133 ? 93  THR B O   1 
ATOM   2973 C CB  . THR B 1 93  ? -33.80802 2.13671   39.71745  1.000 67.20576 ? 93  THR B CB  1 
ATOM   2974 O OG1 . THR B 1 93  ? -33.44939 1.62494   41.00415  1.000 75.79313 ? 93  THR B OG1 1 
ATOM   2975 C CG2 . THR B 1 93  ? -32.73772 3.09730   39.24618  1.000 67.33320 ? 93  THR B CG2 1 
ATOM   2976 N N   . ALA B 1 94  ? -35.60855 4.29818   37.90634  1.000 64.50110 ? 94  ALA B N   1 
ATOM   2977 C CA  . ALA B 1 94  ? -35.84655 4.56937   36.49576  1.000 61.34503 ? 94  ALA B CA  1 
ATOM   2978 C C   . ALA B 1 94  ? -34.57706 4.28003   35.70700  1.000 61.93869 ? 94  ALA B C   1 
ATOM   2979 O O   . ALA B 1 94  ? -33.47838 4.64804   36.12635  1.000 62.53646 ? 94  ALA B O   1 
ATOM   2980 C CB  . ALA B 1 94  ? -36.28595 6.01522   36.28325  1.000 62.24579 ? 94  ALA B CB  1 
ATOM   2981 N N   . ASN B 1 95  ? -34.72525 3.58799   34.57944  1.000 64.04358 ? 95  ASN B N   1 
ATOM   2982 C CA  . ASN B 1 95  ? -33.56234 3.19626   33.78891  1.000 60.58548 ? 95  ASN B CA  1 
ATOM   2983 C C   . ASN B 1 95  ? -32.82580 4.43786   33.29300  1.000 59.44218 ? 95  ASN B C   1 
ATOM   2984 O O   . ASN B 1 95  ? -33.38687 5.20772   32.49696  1.000 59.84664 ? 95  ASN B O   1 
ATOM   2985 C CB  . ASN B 1 95  ? -33.96915 2.31717   32.60505  1.000 58.59340 ? 95  ASN B CB  1 
ATOM   2986 C CG  . ASN B 1 95  ? -32.76221 1.78329   31.81528  1.000 59.11794 ? 95  ASN B CG  1 
ATOM   2987 O OD1 . ASN B 1 95  ? -31.62785 2.22697   32.00513  1.000 59.59135 ? 95  ASN B OD1 1 
ATOM   2988 N ND2 . ASN B 1 95  ? -33.01396 0.83428   30.92136  1.000 54.73560 ? 95  ASN B ND2 1 
ATOM   2989 N N   . PRO B 1 96  ? -31.58321 4.66844   33.72256  1.000 58.85098 ? 96  PRO B N   1 
ATOM   2990 C CA  . PRO B 1 96  ? -30.86217 5.87621   33.27580  1.000 58.67267 ? 96  PRO B CA  1 
ATOM   2991 C C   . PRO B 1 96  ? -30.49091 5.86843   31.79480  1.000 60.38412 ? 96  PRO B C   1 
ATOM   2992 O O   . PRO B 1 96  ? -30.32182 6.94554   31.20660  1.000 56.89395 ? 96  PRO B O   1 
ATOM   2993 C CB  . PRO B 1 96  ? -29.61154 5.88545   34.16431  1.000 55.65980 ? 96  PRO B CB  1 
ATOM   2994 C CG  . PRO B 1 96  ? -29.43850 4.44641   34.59038  1.000 58.72749 ? 96  PRO B CG  1 
ATOM   2995 C CD  . PRO B 1 96  ? -30.80765 3.85798   34.68023  1.000 56.90856 ? 96  PRO B CD  1 
ATOM   2996 N N   . LYS B 1 97  ? -30.36410 4.69879   31.17202  1.000 58.33302 ? 97  LYS B N   1 
ATOM   2997 C CA  . LYS B 1 97  ? -30.03205 4.59891   29.75955  1.000 61.78543 ? 97  LYS B CA  1 
ATOM   2998 C C   . LYS B 1 97  ? -31.26900 4.59649   28.86008  1.000 59.25541 ? 97  LYS B C   1 
ATOM   2999 O O   . LYS B 1 97  ? -31.16510 4.23585   27.68335  1.000 62.42331 ? 97  LYS B O   1 
ATOM   3000 C CB  . LYS B 1 97  ? -29.18446 3.34518   29.51025  1.000 60.74941 ? 97  LYS B CB  1 
ATOM   3001 C CG  . LYS B 1 97  ? -27.83641 3.34861   30.21497  1.000 54.46863 ? 97  LYS B CG  1 
ATOM   3002 C CD  . LYS B 1 97  ? -27.23149 1.95707   30.24508  1.000 59.63835 ? 97  LYS B CD  1 
ATOM   3003 C CE  . LYS B 1 97  ? -25.82127 1.96771   30.82937  1.000 64.25350 ? 97  LYS B CE  1 
ATOM   3004 N NZ  . LYS B 1 97  ? -24.91708 2.90406   30.09663  1.000 71.35707 ? 97  LYS B NZ  1 
ATOM   3005 N N   . THR B 1 98  ? -32.42225 5.00834   29.37235  1.000 58.27580 ? 98  THR B N   1 
ATOM   3006 C CA  . THR B 1 98  ? -33.65228 4.93609   28.59182  1.000 57.35625 ? 98  THR B CA  1 
ATOM   3007 C C   . THR B 1 98  ? -33.57360 5.85815   27.37733  1.000 58.47619 ? 98  THR B C   1 
ATOM   3008 O O   . THR B 1 98  ? -33.33830 7.06550   27.53756  1.000 56.87959 ? 98  THR B O   1 
ATOM   3009 C CB  . THR B 1 98  ? -34.86254 5.30076   29.44903  1.000 59.01729 ? 98  THR B CB  1 
ATOM   3010 O OG1 . THR B 1 98  ? -35.00947 4.34657   30.50669  1.000 58.03484 ? 98  THR B OG1 1 
ATOM   3011 C CG2 . THR B 1 98  ? -36.13312 5.31765   28.60591  1.000 58.47419 ? 98  THR B CG2 1 
ATOM   3012 N N   . PRO B 1 99  ? -33.76261 5.34762   26.16393  1.000 59.14540 ? 99  PRO B N   1 
ATOM   3013 C CA  . PRO B 1 99  ? -33.72459 6.20527   24.98027  1.000 54.05696 ? 99  PRO B CA  1 
ATOM   3014 C C   . PRO B 1 99  ? -35.10009 6.75132   24.63378  1.000 52.11521 ? 99  PRO B C   1 
ATOM   3015 O O   . PRO B 1 99  ? -36.13133 6.27659   25.11208  1.000 54.57209 ? 99  PRO B O   1 
ATOM   3016 C CB  . PRO B 1 99  ? -33.23746 5.24670   23.88791  1.000 53.55111 ? 99  PRO B CB  1 
ATOM   3017 C CG  . PRO B 1 99  ? -33.85266 3.93365   24.28958  1.000 53.61463 ? 99  PRO B CG  1 
ATOM   3018 C CD  . PRO B 1 99  ? -33.91385 3.92330   25.80537  1.000 53.31648 ? 99  PRO B CD  1 
ATOM   3019 N N   . LYS B 1 100 ? -35.09929 7.77437   23.78770  1.000 51.89617 ? 100 LYS B N   1 
ATOM   3020 C CA  . LYS B 1 100 ? -36.33942 8.15324   23.13724  1.000 54.06163 ? 100 LYS B CA  1 
ATOM   3021 C C   . LYS B 1 100 ? -36.92684 6.90613   22.48928  1.000 53.74689 ? 100 LYS B C   1 
ATOM   3022 O O   . LYS B 1 100 ? -36.23568 6.18694   21.76256  1.000 54.36642 ? 100 LYS B O   1 
ATOM   3023 C CB  . LYS B 1 100 ? -36.08899 9.25208   22.09858  1.000 49.97883 ? 100 LYS B CB  1 
ATOM   3024 N N   . TYR B 1 101 ? -38.18596 6.61053   22.78977  1.000 49.07578 ? 101 TYR B N   1 
ATOM   3025 C CA  . TYR B 1 101 ? -38.75928 5.37833   22.27431  1.000 51.86085 ? 101 TYR B CA  1 
ATOM   3026 C C   . TYR B 1 101 ? -40.22921 5.55758   21.96238  1.000 45.70992 ? 101 TYR B C   1 
ATOM   3027 O O   . TYR B 1 101 ? -40.88999 6.48597   22.43439  1.000 48.04519 ? 101 TYR B O   1 
ATOM   3028 C CB  . TYR B 1 101 ? -38.58367 4.20820   23.24370  1.000 49.17725 ? 101 TYR B CB  1 
ATOM   3029 C CG  . TYR B 1 101 ? -39.39603 4.30527   24.51303  1.000 50.56033 ? 101 TYR B CG  1 
ATOM   3030 C CD1 . TYR B 1 101 ? -38.92365 5.01288   25.60908  1.000 52.20304 ? 101 TYR B CD1 1 
ATOM   3031 C CD2 . TYR B 1 101 ? -40.62679 3.65640   24.62911  1.000 53.02028 ? 101 TYR B CD2 1 
ATOM   3032 C CE1 . TYR B 1 101 ? -39.66217 5.08343   26.78773  1.000 54.39382 ? 101 TYR B CE1 1 
ATOM   3033 C CE2 . TYR B 1 101 ? -41.37243 3.72458   25.80258  1.000 50.63207 ? 101 TYR B CE2 1 
ATOM   3034 C CZ  . TYR B 1 101 ? -40.88029 4.44248   26.87351  1.000 53.26401 ? 101 TYR B CZ  1 
ATOM   3035 O OH  . TYR B 1 101 ? -41.60854 4.52785   28.03586  1.000 61.80353 ? 101 TYR B OH  1 
ATOM   3036 N N   . LYS B 1 102 ? -40.72320 4.64336   21.13866  1.000 46.91965 ? 102 LYS B N   1 
ATOM   3037 C CA  . LYS B 1 102 ? -42.14539 4.48348   20.89647  1.000 46.65328 ? 102 LYS B CA  1 
ATOM   3038 C C   . LYS B 1 102 ? -42.45167 2.99578   20.90548  1.000 46.46460 ? 102 LYS B C   1 
ATOM   3039 O O   . LYS B 1 102 ? -41.55780 2.15929   20.74334  1.000 45.59357 ? 102 LYS B O   1 
ATOM   3040 C CB  . LYS B 1 102 ? -42.57273 5.11984   19.56304  1.000 50.58532 ? 102 LYS B CB  1 
ATOM   3041 C CG  . LYS B 1 102 ? -42.23014 6.60760   19.43305  1.000 47.94567 ? 102 LYS B CG  1 
ATOM   3042 N N   . PHE B 1 103 ? -43.72329 2.67932   21.12749  1.000 43.40347 ? 103 PHE B N   1 
ATOM   3043 C CA  . PHE B 1 103 ? -44.27131 1.34576   20.92469  1.000 44.92907 ? 103 PHE B CA  1 
ATOM   3044 C C   . PHE B 1 103 ? -45.11595 1.38596   19.65957  1.000 46.58940 ? 103 PHE B C   1 
ATOM   3045 O O   . PHE B 1 103 ? -46.07357 2.16423   19.57779  1.000 44.35462 ? 103 PHE B O   1 
ATOM   3046 C CB  . PHE B 1 103 ? -45.13491 0.90677   22.10769  1.000 39.59553 ? 103 PHE B CB  1 
ATOM   3047 C CG  . PHE B 1 103 ? -44.36319 0.58625   23.35766  1.000 42.85166 ? 103 PHE B CG  1 
ATOM   3048 C CD1 . PHE B 1 103 ? -42.98088 0.63036   23.37766  1.000 39.51648 ? 103 PHE B CD1 1 
ATOM   3049 C CD2 . PHE B 1 103 ? -45.04411 0.21534   24.52359  1.000 45.54201 ? 103 PHE B CD2 1 
ATOM   3050 C CE1 . PHE B 1 103 ? -42.28025 0.31603   24.53568  1.000 42.34194 ? 103 PHE B CE1 1 
ATOM   3051 C CE2 . PHE B 1 103 ? -44.35591 -0.09478  25.68644  1.000 41.73849 ? 103 PHE B CE2 1 
ATOM   3052 C CZ  . PHE B 1 103 ? -42.97066 -0.05297  25.68829  1.000 48.17042 ? 103 PHE B CZ  1 
ATOM   3053 N N   . VAL B 1 104 ? -44.79469 0.53591   18.69057  1.000 43.01656 ? 104 VAL B N   1 
ATOM   3054 C CA  . VAL B 1 104 ? -45.54559 0.52446   17.44418  1.000 39.75041 ? 104 VAL B CA  1 
ATOM   3055 C C   . VAL B 1 104 ? -45.89578 -0.90403  17.06658  1.000 42.68890 ? 104 VAL B C   1 
ATOM   3056 O O   . VAL B 1 104 ? -45.19988 -1.85593  17.42444  1.000 42.32728 ? 104 VAL B O   1 
ATOM   3057 C CB  . VAL B 1 104 ? -44.76334 1.22410   16.31000  1.000 45.09689 ? 104 VAL B CB  1 
ATOM   3058 C CG1 . VAL B 1 104 ? -44.07309 2.45107   16.86629  1.000 44.20445 ? 104 VAL B CG1 1 
ATOM   3059 C CG2 . VAL B 1 104 ? -43.75804 0.28441   15.67723  1.000 43.41835 ? 104 VAL B CG2 1 
ATOM   3060 N N   . ARG B 1 105 ? -46.98767 -1.04459  16.33636  1.000 41.78352 ? 105 ARG B N   1 
ATOM   3061 C CA  . ARG B 1 105 ? -47.40888 -2.32301  15.79720  1.000 47.62329 ? 105 ARG B CA  1 
ATOM   3062 C C   . ARG B 1 105 ? -47.10871 -2.31383  14.30626  1.000 42.40506 ? 105 ARG B C   1 
ATOM   3063 O O   . ARG B 1 105 ? -47.75250 -1.58615  13.54320  1.000 44.38647 ? 105 ARG B O   1 
ATOM   3064 C CB  . ARG B 1 105 ? -48.89091 -2.56488  16.06816  1.000 44.14929 ? 105 ARG B CB  1 
ATOM   3065 C CG  . ARG B 1 105 ? -49.35357 -3.90409  15.61422  1.000 42.21123 ? 105 ARG B CG  1 
ATOM   3066 C CD  . ARG B 1 105 ? -50.58798 -4.29831  16.33564  1.000 44.09209 ? 105 ARG B CD  1 
ATOM   3067 N NE  . ARG B 1 105 ? -51.05971 -5.59525  15.86601  1.000 45.72604 ? 105 ARG B NE  1 
ATOM   3068 C CZ  . ARG B 1 105 ? -50.79285 -6.74974  16.45743  1.000 43.74764 ? 105 ARG B CZ  1 
ATOM   3069 N NH1 . ARG B 1 105 ? -50.06426 -6.80757  17.55929  1.000 42.72093 ? 105 ARG B NH1 1 
ATOM   3070 N NH2 . ARG B 1 105 ? -51.28510 -7.87227  15.93895  1.000 39.92080 ? 105 ARG B NH2 1 
ATOM   3071 N N   . ILE B 1 106 ? -46.15096 -3.14035  13.89543  1.000 39.16559 ? 106 ILE B N   1 
ATOM   3072 C CA  A ILE B 1 106 ? -45.74495 -3.13233  12.49786  0.500 42.91406 ? 106 ILE B CA  1 
ATOM   3073 C CA  B ILE B 1 106 ? -45.70377 -3.18805  12.51222  0.500 43.05126 ? 106 ILE B CA  1 
ATOM   3074 C C   . ILE B 1 106 ? -46.67290 -4.02138  11.67998  1.000 45.36130 ? 106 ILE B C   1 
ATOM   3075 O O   . ILE B 1 106 ? -47.36272 -4.90763  12.19017  1.000 45.96764 ? 106 ILE B O   1 
ATOM   3076 C CB  A ILE B 1 106 ? -44.27287 -3.55188  12.32494  0.500 41.27284 ? 106 ILE B CB  1 
ATOM   3077 C CB  B ILE B 1 106 ? -44.27539 -3.75915  12.45808  0.500 41.32850 ? 106 ILE B CB  1 
ATOM   3078 C CG1 A ILE B 1 106 ? -43.93435 -4.71714  13.25171  0.500 41.05173 ? 106 ILE B CG1 1 
ATOM   3079 C CG1 B ILE B 1 106 ? -43.49313 -3.19748  11.28129  0.500 41.33474 ? 106 ILE B CG1 1 
ATOM   3080 C CG2 A ILE B 1 106 ? -43.34562 -2.36801  12.53700  0.500 42.14450 ? 106 ILE B CG2 1 
ATOM   3081 C CG2 B ILE B 1 106 ? -44.30231 -5.28338  12.40761  0.500 40.76907 ? 106 ILE B CG2 1 
ATOM   3082 C CD1 A ILE B 1 106 ? -44.60526 -5.99216  12.85731  0.500 41.66901 ? 106 ILE B CD1 1 
ATOM   3083 C CD1 B ILE B 1 106 ? -42.01033 -3.48822  11.39230  0.500 40.40937 ? 106 ILE B CD1 1 
ATOM   3084 N N   . GLN B 1 107 ? -46.70057 -3.75933  10.38844  1.000 43.96485 ? 107 GLN B N   1 
ATOM   3085 C CA  . GLN B 1 107 ? -47.51305 -4.49039  9.42376   1.000 44.22126 ? 107 GLN B CA  1 
ATOM   3086 C C   . GLN B 1 107 ? -46.74581 -5.67789  8.85663   1.000 41.83109 ? 107 GLN B C   1 
ATOM   3087 O O   . GLN B 1 107 ? -45.51639 -5.64083  8.75294   1.000 43.64031 ? 107 GLN B O   1 
ATOM   3088 C CB  . GLN B 1 107 ? -47.92764 -3.58212  8.25848   1.000 50.69207 ? 107 GLN B CB  1 
ATOM   3089 C CG  . GLN B 1 107 ? -48.70398 -2.33025  8.63226   1.000 51.76573 ? 107 GLN B CG  1 
ATOM   3090 C CD  . GLN B 1 107 ? -47.82058 -1.20824  9.18455   1.000 60.20013 ? 107 GLN B CD  1 
ATOM   3091 O OE1 . GLN B 1 107 ? -46.57898 -1.27136  9.13863   1.000 63.07933 ? 107 GLN B OE1 1 
ATOM   3092 N NE2 . GLN B 1 107 ? -48.46339 -0.16843  9.71139   1.000 62.48013 ? 107 GLN B NE2 1 
ATOM   3093 N N   . PRO B 1 108 ? -47.45971 -6.72206  8.44040   1.000 45.71998 ? 108 PRO B N   1 
ATOM   3094 C CA  . PRO B 1 108 ? -46.80550 -7.80701  7.70116   1.000 39.91702 ? 108 PRO B CA  1 
ATOM   3095 C C   . PRO B 1 108 ? -46.10120 -7.25857  6.46303   1.000 41.69746 ? 108 PRO B C   1 
ATOM   3096 O O   . PRO B 1 108 ? -46.63246 -6.41591  5.73296   1.000 37.64352 ? 108 PRO B O   1 
ATOM   3097 C CB  . PRO B 1 108 ? -47.96761 -8.74408  7.34011   1.000 40.55397 ? 108 PRO B CB  1 
ATOM   3098 C CG  . PRO B 1 108 ? -49.14036 -7.84917  7.27394   1.000 44.66908 ? 108 PRO B CG  1 
ATOM   3099 C CD  . PRO B 1 108 ? -48.92330 -6.76547  8.31235   1.000 39.17658 ? 108 PRO B CD  1 
ATOM   3100 N N   . GLY B 1 109 ? -44.87489 -7.72278  6.25142   1.000 40.91743 ? 109 GLY B N   1 
ATOM   3101 C CA  . GLY B 1 109 ? -44.04664 -7.25310  5.18009   1.000 42.39870 ? 109 GLY B CA  1 
ATOM   3102 C C   . GLY B 1 109 ? -42.97158 -6.28167  5.62164   1.000 38.46328 ? 109 GLY B C   1 
ATOM   3103 O O   . GLY B 1 109 ? -41.93267 -6.19509  4.96238   1.000 43.21716 ? 109 GLY B O   1 
ATOM   3104 N N   . GLN B 1 110 ? -43.18958 -5.56260  6.72448   1.000 39.31342 ? 110 GLN B N   1 
ATOM   3105 C CA  . GLN B 1 110 ? -42.18619 -4.66574  7.28711   1.000 39.97424 ? 110 GLN B CA  1 
ATOM   3106 C C   . GLN B 1 110 ? -41.09823 -5.46553  7.99724   1.000 40.93388 ? 110 GLN B C   1 
ATOM   3107 O O   . GLN B 1 110 ? -41.31541 -6.59704  8.43623   1.000 38.65716 ? 110 GLN B O   1 
ATOM   3108 C CB  . GLN B 1 110 ? -42.82058 -3.67532  8.26563   1.000 38.50466 ? 110 GLN B CB  1 
ATOM   3109 C CG  . GLN B 1 110 ? -43.74582 -2.70725  7.59310   1.000 42.68168 ? 110 GLN B CG  1 
ATOM   3110 C CD  . GLN B 1 110 ? -43.04721 -2.00605  6.43832   1.000 46.14727 ? 110 GLN B CD  1 
ATOM   3111 O OE1 . GLN B 1 110 ? -42.13818 -1.18966  6.65092   1.000 50.65279 ? 110 GLN B OE1 1 
ATOM   3112 N NE2 . GLN B 1 110 ? -43.44164 -2.34310  5.20884   1.000 42.92187 ? 110 GLN B NE2 1 
ATOM   3113 N N   . THR B 1 111 ? -39.91400 -4.86731  8.09976   1.000 35.23796 ? 111 THR B N   1 
ATOM   3114 C CA  . THR B 1 111 ? -38.77035 -5.52985  8.70227   1.000 32.99957 ? 111 THR B CA  1 
ATOM   3115 C C   . THR B 1 111 ? -38.41636 -4.83672  10.00726  1.000 31.25429 ? 111 THR B C   1 
ATOM   3116 O O   . THR B 1 111 ? -38.88929 -3.74266  10.30078  1.000 36.99699 ? 111 THR B O   1 
ATOM   3117 C CB  . THR B 1 111 ? -37.55873 -5.53965  7.75926   1.000 34.15161 ? 111 THR B CB  1 
ATOM   3118 O OG1 . THR B 1 111 ? -37.20711 -4.19009  7.40004   1.000 35.92851 ? 111 THR B OG1 1 
ATOM   3119 C CG2 . THR B 1 111 ? -37.85297 -6.36545  6.53751   1.000 31.58911 ? 111 THR B CG2 1 
ATOM   3120 N N   . PHE B 1 112 ? -37.56569 -5.49555  10.78783  1.000 31.34265 ? 112 PHE B N   1 
ATOM   3121 C CA  . PHE B 1 112 ? -37.06968 -4.94153  12.03850  1.000 32.40885 ? 112 PHE B CA  1 
ATOM   3122 C C   . PHE B 1 112 ? -35.85070 -5.74290  12.46808  1.000 35.06291 ? 112 PHE B C   1 
ATOM   3123 O O   . PHE B 1 112 ? -35.56953 -6.82716  11.95421  1.000 37.93771 ? 112 PHE B O   1 
ATOM   3124 C CB  . PHE B 1 112 ? -38.15142 -4.91191  13.15197  1.000 35.32511 ? 112 PHE B CB  1 
ATOM   3125 C CG  . PHE B 1 112 ? -38.80694 -6.24843  13.43873  1.000 37.75580 ? 112 PHE B CG  1 
ATOM   3126 C CD1 . PHE B 1 112 ? -38.26149 -7.13001  14.37118  1.000 38.27845 ? 112 PHE B CD1 1 
ATOM   3127 C CD2 . PHE B 1 112 ? -39.99161 -6.60148  12.81169  1.000 40.16539 ? 112 PHE B CD2 1 
ATOM   3128 C CE1 . PHE B 1 112 ? -38.87709 -8.34079  14.66877  1.000 40.42701 ? 112 PHE B CE1 1 
ATOM   3129 C CE2 . PHE B 1 112 ? -40.62771 -7.82918  13.10208  1.000 40.38810 ? 112 PHE B CE2 1 
ATOM   3130 C CZ  . PHE B 1 112 ? -40.05293 -8.70259  14.02376  1.000 40.28707 ? 112 PHE B CZ  1 
ATOM   3131 N N   . SER B 1 113 ? -35.11760 -5.17701  13.40454  1.000 35.51929 ? 113 SER B N   1 
ATOM   3132 C CA  . SER B 1 113 ? -33.95261 -5.81369  13.98923  1.000 37.14352 ? 113 SER B CA  1 
ATOM   3133 C C   . SER B 1 113 ? -34.35474 -6.47125  15.29663  1.000 36.39664 ? 113 SER B C   1 
ATOM   3134 O O   . SER B 1 113 ? -35.21831 -5.97175  16.02106  1.000 35.58727 ? 113 SER B O   1 
ATOM   3135 C CB  . SER B 1 113 ? -32.84526 -4.79209  14.26756  1.000 40.41442 ? 113 SER B CB  1 
ATOM   3136 O OG  . SER B 1 113 ? -32.59095 -3.97643  13.13931  1.000 36.96881 ? 113 SER B OG  1 
ATOM   3137 N N   . VAL B 1 114 ? -33.67806 -7.56223  15.61391  1.000 33.34764 ? 114 VAL B N   1 
ATOM   3138 C CA  . VAL B 1 114 ? -33.93274 -8.34013  16.81541  1.000 37.64997 ? 114 VAL B CA  1 
ATOM   3139 C C   . VAL B 1 114 ? -32.63229 -8.38912  17.59592  1.000 37.15115 ? 114 VAL B C   1 
ATOM   3140 O O   . VAL B 1 114 ? -31.58849 -8.73614  17.03500  1.000 38.90155 ? 114 VAL B O   1 
ATOM   3141 C CB  . VAL B 1 114 ? -34.40697 -9.76929  16.47609  1.000 35.67297 ? 114 VAL B CB  1 
ATOM   3142 C CG1 . VAL B 1 114 ? -34.40149 -10.64684 17.73129  1.000 34.99349 ? 114 VAL B CG1 1 
ATOM   3143 C CG2 . VAL B 1 114 ? -35.77091 -9.74729  15.81047  1.000 37.97022 ? 114 VAL B CG2 1 
ATOM   3144 N N   . LEU B 1 115 ? -32.68780 -8.06086  18.88147  1.000 39.42633 ? 115 LEU B N   1 
ATOM   3145 C CA  . LEU B 1 115 ? -31.54268 -8.27559  19.76258  1.000 40.20254 ? 115 LEU B CA  1 
ATOM   3146 C C   . LEU B 1 115 ? -31.83653 -9.53323  20.56724  1.000 40.61132 ? 115 LEU B C   1 
ATOM   3147 O O   . LEU B 1 115 ? -32.63334 -9.50775  21.51237  1.000 41.94360 ? 115 LEU B O   1 
ATOM   3148 C CB  . LEU B 1 115 ? -31.28309 -7.06593  20.65442  1.000 40.61335 ? 115 LEU B CB  1 
ATOM   3149 C CG  . LEU B 1 115 ? -30.04477 -7.11731  21.55390  1.000 39.02446 ? 115 LEU B CG  1 
ATOM   3150 C CD1 . LEU B 1 115 ? -28.73090 -7.14781  20.74555  1.000 41.46360 ? 115 LEU B CD1 1 
ATOM   3151 C CD2 . LEU B 1 115 ? -30.06077 -5.96987  22.53731  1.000 41.42828 ? 115 LEU B CD2 1 
ATOM   3152 N N   . ALA B 1 116 ? -31.21868 -10.64394 20.15849  1.000 41.23905 ? 116 ALA B N   1 
ATOM   3153 C CA  . ALA B 1 116 ? -31.34694 -11.89285 20.89287  1.000 41.06557 ? 116 ALA B CA  1 
ATOM   3154 C C   . ALA B 1 116 ? -30.59024 -11.79771 22.20841  1.000 46.79234 ? 116 ALA B C   1 
ATOM   3155 O O   . ALA B 1 116 ? -29.40157 -11.45864 22.22667  1.000 45.13471 ? 116 ALA B O   1 
ATOM   3156 C CB  . ALA B 1 116 ? -30.81820 -13.06402 20.07179  1.000 39.56158 ? 116 ALA B CB  1 
ATOM   3157 N N   . CYS B 1 117 ? -31.29206 -12.08780 23.30617  1.000 39.52286 ? 117 CYS B N   1 
ATOM   3158 C CA  . CYS B 1 117 ? -30.76849 -11.99010 24.66377  1.000 44.08809 ? 117 CYS B CA  1 
ATOM   3159 C C   . CYS B 1 117 ? -31.06197 -13.26893 25.43013  1.000 47.60823 ? 117 CYS B C   1 
ATOM   3160 O O   . CYS B 1 117 ? -32.04655 -13.95266 25.15806  1.000 42.91486 ? 117 CYS B O   1 
ATOM   3161 C CB  . CYS B 1 117 ? -31.39011 -10.82868 25.45091  1.000 42.59402 ? 117 CYS B CB  1 
ATOM   3162 S SG  . CYS B 1 117 ? -31.00670 -9.20252  24.79459  1.000 55.03565 ? 117 CYS B SG  1 
ATOM   3163 N N   . TYR B 1 118 ? -30.19272 -13.57771 26.39432  1.000 52.49051 ? 118 TYR B N   1 
ATOM   3164 C CA  . TYR B 1 118 ? -30.39210 -14.66723 27.34611  1.000 49.89893 ? 118 TYR B CA  1 
ATOM   3165 C C   . TYR B 1 118 ? -29.95168 -14.15514 28.70886  1.000 51.44046 ? 118 TYR B C   1 
ATOM   3166 O O   . TYR B 1 118 ? -28.92581 -13.47494 28.80254  1.000 49.89037 ? 118 TYR B O   1 
ATOM   3167 C CB  . TYR B 1 118 ? -29.60445 -15.91058 26.91431  1.000 47.60178 ? 118 TYR B CB  1 
ATOM   3168 C CG  . TYR B 1 118 ? -30.03642 -16.37766 25.54347  1.000 48.16848 ? 118 TYR B CG  1 
ATOM   3169 C CD1 . TYR B 1 118 ? -31.11443 -17.24474 25.40366  1.000 43.85420 ? 118 TYR B CD1 1 
ATOM   3170 C CD2 . TYR B 1 118 ? -29.40441 -15.91701 24.38744  1.000 43.16060 ? 118 TYR B CD2 1 
ATOM   3171 C CE1 . TYR B 1 118 ? -31.54557 -17.65843 24.17116  1.000 44.71012 ? 118 TYR B CE1 1 
ATOM   3172 C CE2 . TYR B 1 118 ? -29.82978 -16.32944 23.13167  1.000 46.00791 ? 118 TYR B CE2 1 
ATOM   3173 C CZ  . TYR B 1 118 ? -30.91016 -17.20761 23.03749  1.000 48.08776 ? 118 TYR B CZ  1 
ATOM   3174 O OH  . TYR B 1 118 ? -31.37048 -17.64166 21.81480  1.000 44.66762 ? 118 TYR B OH  1 
ATOM   3175 N N   . ASN B 1 119 ? -30.75898 -14.41646 29.74517  1.000 51.14238 ? 119 ASN B N   1 
ATOM   3176 C CA  . ASN B 1 119 ? -30.46223 -13.96716 31.11357  1.000 53.62008 ? 119 ASN B CA  1 
ATOM   3177 C C   . ASN B 1 119 ? -30.15703 -12.46775 31.17372  1.000 52.75659 ? 119 ASN B C   1 
ATOM   3178 O O   . ASN B 1 119 ? -29.38128 -12.00543 32.00949  1.000 54.05219 ? 119 ASN B O   1 
ATOM   3179 C CB  . ASN B 1 119 ? -29.30819 -14.77258 31.71444  1.000 54.72258 ? 119 ASN B CB  1 
ATOM   3180 C CG  . ASN B 1 119 ? -29.56030 -16.26063 31.66627  1.000 57.61086 ? 119 ASN B CG  1 
ATOM   3181 O OD1 . ASN B 1 119 ? -28.88550 -16.99066 30.93478  1.000 64.38987 ? 119 ASN B OD1 1 
ATOM   3182 N ND2 . ASN B 1 119 ? -30.54370 -16.72342 32.43964  1.000 53.99142 ? 119 ASN B ND2 1 
ATOM   3183 N N   . GLY B 1 120 ? -30.76324 -11.69385 30.28483  1.000 50.93371 ? 120 GLY B N   1 
ATOM   3184 C CA  . GLY B 1 120 ? -30.58862 -10.26173 30.28797  1.000 55.79671 ? 120 GLY B CA  1 
ATOM   3185 C C   . GLY B 1 120 ? -29.38552 -9.74136  29.53206  1.000 51.99567 ? 120 GLY B C   1 
ATOM   3186 O O   . GLY B 1 120 ? -29.16739 -8.52567  29.52631  1.000 54.78919 ? 120 GLY B O   1 
ATOM   3187 N N   . SER B 1 121 ? -28.60170 -10.60965 28.89010  1.000 52.56842 ? 121 SER B N   1 
ATOM   3188 C CA  . SER B 1 121 ? -27.40035 -10.16341 28.19495  1.000 53.66378 ? 121 SER B CA  1 
ATOM   3189 C C   . SER B 1 121 ? -27.53033 -10.37021 26.69598  1.000 54.26114 ? 121 SER B C   1 
ATOM   3190 O O   . SER B 1 121 ? -27.87242 -11.47490 26.25472  1.000 46.95377 ? 121 SER B O   1 
ATOM   3191 C CB  . SER B 1 121 ? -26.17140 -10.91486 28.70925  1.000 52.90537 ? 121 SER B CB  1 
ATOM   3192 O OG  . SER B 1 121 ? -26.07609 -10.77758 30.11119  1.000 59.36138 ? 121 SER B OG  1 
ATOM   3193 N N   . PRO B 1 122 ? -27.24549 -9.35100  25.88737  1.000 53.25258 ? 122 PRO B N   1 
ATOM   3194 C CA  . PRO B 1 122 ? -27.31276 -9.52659  24.43375  1.000 52.37190 ? 122 PRO B CA  1 
ATOM   3195 C C   . PRO B 1 122 ? -26.36534 -10.61140 23.94208  1.000 52.32387 ? 122 PRO B C   1 
ATOM   3196 O O   . PRO B 1 122 ? -25.23015 -10.73583 24.41112  1.000 50.14194 ? 122 PRO B O   1 
ATOM   3197 C CB  . PRO B 1 122 ? -26.91636 -8.14797  23.90009  1.000 54.87703 ? 122 PRO B CB  1 
ATOM   3198 C CG  . PRO B 1 122 ? -27.36481 -7.21072  24.98836  1.000 57.46290 ? 122 PRO B CG  1 
ATOM   3199 C CD  . PRO B 1 122 ? -27.05649 -7.93855  26.26264  1.000 56.96872 ? 122 PRO B CD  1 
ATOM   3200 N N   . SER B 1 123 ? -26.85565 -11.40203 22.98393  1.000 46.84955 ? 123 SER B N   1 
ATOM   3201 C CA  . SER B 1 123 ? -26.06149 -12.40568 22.28910  1.000 46.92752 ? 123 SER B CA  1 
ATOM   3202 C C   . SER B 1 123 ? -25.71004 -12.03118 20.84663  1.000 50.35987 ? 123 SER B C   1 
ATOM   3203 O O   . SER B 1 123 ? -24.63652 -12.41435 20.37091  1.000 47.31495 ? 123 SER B O   1 
ATOM   3204 C CB  . SER B 1 123 ? -26.80022 -13.75244 22.28789  1.000 50.72818 ? 123 SER B CB  1 
ATOM   3205 O OG  . SER B 1 123 ? -25.97037 -14.77893 21.76490  1.000 58.00024 ? 123 SER B OG  1 
ATOM   3206 N N   . GLY B 1 124 ? -26.57055 -11.27797 20.14685  1.000 46.18253 ? 124 GLY B N   1 
ATOM   3207 C CA  . GLY B 1 124 ? -26.40074 -10.99254 18.72998  1.000 38.88822 ? 124 GLY B CA  1 
ATOM   3208 C C   . GLY B 1 124 ? -27.57730 -10.24367 18.12714  1.000 42.63899 ? 124 GLY B C   1 
ATOM   3209 O O   . GLY B 1 124 ? -28.66315 -10.18341 18.72095  1.000 42.47925 ? 124 GLY B O   1 
ATOM   3210 N N   . VAL B 1 125 ? -27.39061 -9.67858  16.93663  1.000 39.04154 ? 125 VAL B N   1 
ATOM   3211 C CA  . VAL B 1 125 ? -28.39085 -8.81269  16.32777  1.000 40.55841 ? 125 VAL B CA  1 
ATOM   3212 C C   . VAL B 1 125 ? -28.59220 -9.24392  14.88047  1.000 38.13714 ? 125 VAL B C   1 
ATOM   3213 O O   . VAL B 1 125 ? -27.62425 -9.57177  14.18366  1.000 42.24029 ? 125 VAL B O   1 
ATOM   3214 C CB  . VAL B 1 125 ? -27.96301 -7.32939  16.43707  1.000 35.70184 ? 125 VAL B CB  1 
ATOM   3215 C CG1 . VAL B 1 125 ? -26.70209 -7.09865  15.67516  1.000 45.31860 ? 125 VAL B CG1 1 
ATOM   3216 C CG2 . VAL B 1 125 ? -29.05174 -6.40324  15.95210  1.000 38.71317 ? 125 VAL B CG2 1 
ATOM   3217 N N   . TYR B 1 126 ? -29.84946 -9.27392  14.43505  1.000 37.19889 ? 126 TYR B N   1 
ATOM   3218 C CA  . TYR B 1 126 ? -30.14458 -9.71438  13.07512  1.000 35.55446 ? 126 TYR B CA  1 
ATOM   3219 C C   . TYR B 1 126 ? -31.47016 -9.10756  12.64301  1.000 39.48929 ? 126 TYR B C   1 
ATOM   3220 O O   . TYR B 1 126 ? -32.25789 -8.64087  13.47052  1.000 39.86239 ? 126 TYR B O   1 
ATOM   3221 C CB  . TYR B 1 126 ? -30.17755 -11.25689 12.95533  1.000 38.32164 ? 126 TYR B CB  1 
ATOM   3222 C CG  . TYR B 1 126 ? -31.14835 -11.97256 13.89977  1.000 41.66819 ? 126 TYR B CG  1 
ATOM   3223 C CD1 . TYR B 1 126 ? -32.49812 -12.08066 13.60173  1.000 40.20574 ? 126 TYR B CD1 1 
ATOM   3224 C CD2 . TYR B 1 126 ? -30.69643 -12.55748 15.07375  1.000 41.30514 ? 126 TYR B CD2 1 
ATOM   3225 C CE1 . TYR B 1 126 ? -33.38665 -12.73919 14.47100  1.000 43.44766 ? 126 TYR B CE1 1 
ATOM   3226 C CE2 . TYR B 1 126 ? -31.56459 -13.20313 15.94240  1.000 43.17728 ? 126 TYR B CE2 1 
ATOM   3227 C CZ  . TYR B 1 126 ? -32.90298 -13.29791 15.64028  1.000 42.50386 ? 126 TYR B CZ  1 
ATOM   3228 O OH  . TYR B 1 126 ? -33.73451 -13.96093 16.52080  1.000 45.56087 ? 126 TYR B OH  1 
ATOM   3229 N N   . GLN B 1 127 ? -31.70358 -9.12917  11.32997  1.000 39.69564 ? 127 GLN B N   1 
ATOM   3230 C CA  . GLN B 1 127 ? -32.92207 -8.61843  10.70168  1.000 38.94725 ? 127 GLN B CA  1 
ATOM   3231 C C   . GLN B 1 127 ? -33.91467 -9.73137  10.43465  1.000 42.40894 ? 127 GLN B C   1 
ATOM   3232 O O   . GLN B 1 127 ? -33.52859 -10.81509 9.98524   1.000 45.31920 ? 127 GLN B O   1 
ATOM   3233 C CB  . GLN B 1 127 ? -32.61873 -7.95469  9.35636   1.000 41.06136 ? 127 GLN B CB  1 
ATOM   3234 C CG  . GLN B 1 127 ? -31.97289 -6.63642  9.45050   1.000 39.95880 ? 127 GLN B CG  1 
ATOM   3235 C CD  . GLN B 1 127 ? -32.90702 -5.59372  9.99805   1.000 39.30927 ? 127 GLN B CD  1 
ATOM   3236 O OE1 . GLN B 1 127 ? -32.81775 -5.23757  11.17219  1.000 39.90492 ? 127 GLN B OE1 1 
ATOM   3237 N NE2 . GLN B 1 127 ? -33.79455 -5.06700  9.14332   1.000 35.00006 ? 127 GLN B NE2 1 
ATOM   3238 N N   . CYS B 1 128 ? -35.19995 -9.43005  10.67226  1.000 40.18992 ? 128 CYS B N   1 
ATOM   3239 C CA  . CYS B 1 128 ? -36.33814 -10.29032 10.36974  1.000 43.06939 ? 128 CYS B CA  1 
ATOM   3240 C C   . CYS B 1 128 ? -37.39854 -9.46335  9.66390   1.000 41.32377 ? 128 CYS B C   1 
ATOM   3241 O O   . CYS B 1 128 ? -37.48787 -8.24884  9.86249   1.000 34.76023 ? 128 CYS B O   1 
ATOM   3242 C CB  . CYS B 1 128 ? -37.00234 -10.87361 11.62434  1.000 39.64039 ? 128 CYS B CB  1 
ATOM   3243 S SG  . CYS B 1 128 ? -35.94627 -11.84318 12.63654  1.000 49.89218 ? 128 CYS B SG  1 
ATOM   3244 N N   . ALA B 1 129 ? -38.22571 -10.12957 8.86708   1.000 34.66894 ? 129 ALA B N   1 
ATOM   3245 C CA  . ALA B 1 129 ? -39.44626 -9.52236  8.37455   1.000 33.45277 ? 129 ALA B CA  1 
ATOM   3246 C C   . ALA B 1 129 ? -40.62209 -10.18395 9.07302   1.000 35.80532 ? 129 ALA B C   1 
ATOM   3247 O O   . ALA B 1 129 ? -40.60640 -11.39890 9.31576   1.000 38.13719 ? 129 ALA B O   1 
ATOM   3248 C CB  . ALA B 1 129 ? -39.59155 -9.67547  6.86307   1.000 29.81843 ? 129 ALA B CB  1 
ATOM   3249 N N   . MET B 1 130 ? -41.63649 -9.38970  9.39164   1.000 37.96977 ? 130 MET B N   1 
ATOM   3250 C CA  . MET B 1 130 ? -42.91690 -9.95725  9.80648   1.000 39.16361 ? 130 MET B CA  1 
ATOM   3251 C C   . MET B 1 130 ? -43.53971 -10.60312 8.57411   1.000 42.80842 ? 130 MET B C   1 
ATOM   3252 O O   . MET B 1 130 ? -43.88779 -9.90472  7.61650   1.000 44.79622 ? 130 MET B O   1 
ATOM   3253 C CB  . MET B 1 130 ? -43.80082 -8.86045  10.39796  1.000 39.66172 ? 130 MET B CB  1 
ATOM   3254 C CG  . MET B 1 130 ? -45.21993 -9.25814  10.78327  1.000 43.26589 ? 130 MET B CG  1 
ATOM   3255 S SD  . MET B 1 130 ? -45.27152 -10.47612 12.09985  1.000 46.20705 ? 130 MET B SD  1 
ATOM   3256 C CE  . MET B 1 130 ? -44.42478 -9.66126  13.42928  1.000 37.95863 ? 130 MET B CE  1 
ATOM   3257 N N   . ARG B 1 131 ? -43.59590 -11.93607 8.55475   1.000 39.74618 ? 131 ARG B N   1 
ATOM   3258 C CA  . ARG B 1 131 ? -44.14973 -12.66146 7.41758   1.000 37.84714 ? 131 ARG B CA  1 
ATOM   3259 C C   . ARG B 1 131 ? -45.62606 -12.31780 7.22424   1.000 41.53087 ? 131 ARG B C   1 
ATOM   3260 O O   . ARG B 1 131 ? -46.31162 -11.93380 8.17449   1.000 42.00549 ? 131 ARG B O   1 
ATOM   3261 C CB  . ARG B 1 131 ? -44.02323 -14.17025 7.61791   1.000 41.35804 ? 131 ARG B CB  1 
ATOM   3262 C CG  . ARG B 1 131 ? -42.62718 -14.65066 7.98045   1.000 43.15931 ? 131 ARG B CG  1 
ATOM   3263 C CD  . ARG B 1 131 ? -41.65014 -14.38211 6.85796   1.000 35.58739 ? 131 ARG B CD  1 
ATOM   3264 N NE  . ARG B 1 131 ? -42.20051 -14.71657 5.54825   1.000 38.57808 ? 131 ARG B NE  1 
ATOM   3265 C CZ  . ARG B 1 131 ? -41.71237 -14.26495 4.39690   1.000 44.69499 ? 131 ARG B CZ  1 
ATOM   3266 N NH1 . ARG B 1 131 ? -40.64359 -13.47820 4.36135   1.000 34.10994 ? 131 ARG B NH1 1 
ATOM   3267 N NH2 . ARG B 1 131 ? -42.29331 -14.63281 3.25284   1.000 37.03374 ? 131 ARG B NH2 1 
ATOM   3268 N N   . PRO B 1 132 ? -46.14768 -12.46386 6.00700   1.000 38.34529 ? 132 PRO B N   1 
ATOM   3269 C CA  . PRO B 1 132 ? -47.59179 -12.27794 5.81402   1.000 41.28474 ? 132 PRO B CA  1 
ATOM   3270 C C   . PRO B 1 132 ? -48.46111 -13.10987 6.76230   1.000 39.06880 ? 132 PRO B C   1 
ATOM   3271 O O   . PRO B 1 132 ? -49.56524 -12.66579 7.09136   1.000 40.57715 ? 132 PRO B O   1 
ATOM   3272 C CB  . PRO B 1 132 ? -47.79185 -12.68205 4.34512   1.000 44.35381 ? 132 PRO B CB  1 
ATOM   3273 C CG  . PRO B 1 132 ? -46.52261 -12.26285 3.69300   1.000 41.00433 ? 132 PRO B CG  1 
ATOM   3274 C CD  . PRO B 1 132 ? -45.44689 -12.64024 4.72184   1.000 40.48655 ? 132 PRO B CD  1 
ATOM   3275 N N   . ASN B 1 133 ? -48.00890 -14.28861 7.21274   1.000 40.42574 ? 133 ASN B N   1 
ATOM   3276 C CA  . ASN B 1 133 ? -48.76210 -15.09916 8.16532   1.000 42.00103 ? 133 ASN B CA  1 
ATOM   3277 C C   . ASN B 1 133 ? -48.42368 -14.76110 9.61307   1.000 41.09756 ? 133 ASN B C   1 
ATOM   3278 O O   . ASN B 1 133 ? -48.66231 -15.58621 10.49924  1.000 39.23567 ? 133 ASN B O   1 
ATOM   3279 C CB  . ASN B 1 133 ? -48.53860 -16.59273 7.89899   1.000 42.75926 ? 133 ASN B CB  1 
ATOM   3280 C CG  . ASN B 1 133 ? -47.13406 -17.05724 8.24255   1.000 45.19526 ? 133 ASN B CG  1 
ATOM   3281 O OD1 . ASN B 1 133 ? -46.26692 -16.26621 8.64499   1.000 37.56868 ? 133 ASN B OD1 1 
ATOM   3282 N ND2 . ASN B 1 133 ? -46.90448 -18.36111 8.09109   1.000 41.45989 ? 133 ASN B ND2 1 
ATOM   3283 N N   . PHE B 1 134 ? -47.84123 -13.58108 9.85586   1.000 39.28065 ? 134 PHE B N   1 
ATOM   3284 C CA  . PHE B 1 134 ? -47.58715 -13.01277 11.18150  1.000 40.30664 ? 134 PHE B CA  1 
ATOM   3285 C C   . PHE B 1 134 ? -46.57286 -13.79763 11.99500  1.000 42.24375 ? 134 PHE B C   1 
ATOM   3286 O O   . PHE B 1 134 ? -46.47595 -13.61217 13.21259  1.000 49.89647 ? 134 PHE B O   1 
ATOM   3287 C CB  . PHE B 1 134 ? -48.88431 -12.84727 11.98504  1.000 35.78002 ? 134 PHE B CB  1 
ATOM   3288 C CG  . PHE B 1 134 ? -49.79054 -11.80939 11.40874  1.000 41.21614 ? 134 PHE B CG  1 
ATOM   3289 C CD1 . PHE B 1 134 ? -49.44296 -10.47526 11.48515  1.000 42.09521 ? 134 PHE B CD1 1 
ATOM   3290 C CD2 . PHE B 1 134 ? -50.94298 -12.16447 10.72887  1.000 41.94873 ? 134 PHE B CD2 1 
ATOM   3291 C CE1 . PHE B 1 134 ? -50.25390 -9.50036  10.93251  1.000 48.88293 ? 134 PHE B CE1 1 
ATOM   3292 C CE2 . PHE B 1 134 ? -51.76545 -11.19719 10.17211  1.000 43.36544 ? 134 PHE B CE2 1 
ATOM   3293 C CZ  . PHE B 1 134 ? -51.41973 -9.86141  10.27382  1.000 47.83843 ? 134 PHE B CZ  1 
ATOM   3294 N N   . THR B 1 135 ? -45.82005 -14.67569 11.36197  1.000 41.80283 ? 135 THR B N   1 
ATOM   3295 C CA  . THR B 1 135 ? -44.67630 -15.30623 11.99426  1.000 39.28527 ? 135 THR B CA  1 
ATOM   3296 C C   . THR B 1 135 ? -43.40424 -14.59053 11.55644  1.000 39.38268 ? 135 THR B C   1 
ATOM   3297 O O   . THR B 1 135 ? -43.39461 -13.81930 10.59849  1.000 39.02106 ? 135 THR B O   1 
ATOM   3298 C CB  . THR B 1 135 ? -44.61377 -16.77830 11.61648  1.000 39.37721 ? 135 THR B CB  1 
ATOM   3299 O OG1 . THR B 1 135 ? -44.39413 -16.88695 10.20698  1.000 39.41989 ? 135 THR B OG1 1 
ATOM   3300 C CG2 . THR B 1 135 ? -45.94658 -17.47191 11.95251  1.000 41.72312 ? 135 THR B CG2 1 
ATOM   3301 N N   . ILE B 1 136 ? -42.32582 -14.85008 12.27077  1.000 39.18764 ? 136 ILE B N   1 
ATOM   3302 C CA  . ILE B 1 136 ? -41.01802 -14.37766 11.84669  1.000 44.18634 ? 136 ILE B CA  1 
ATOM   3303 C C   . ILE B 1 136 ? -40.08786 -15.57251 11.87130  1.000 44.68395 ? 136 ILE B C   1 
ATOM   3304 O O   . ILE B 1 136 ? -40.27561 -16.51106 12.65518  1.000 38.91329 ? 136 ILE B O   1 
ATOM   3305 C CB  . ILE B 1 136 ? -40.47230 -13.23188 12.72711  1.000 39.65014 ? 136 ILE B CB  1 
ATOM   3306 C CG1 . ILE B 1 136 ? -40.07779 -13.75036 14.11625  1.000 38.59141 ? 136 ILE B CG1 1 
ATOM   3307 C CG2 . ILE B 1 136 ? -41.49268 -12.08043 12.81075  1.000 37.95666 ? 136 ILE B CG2 1 
ATOM   3308 C CD1 . ILE B 1 136 ? -39.29425 -12.74830 14.94726  1.000 40.95324 ? 136 ILE B CD1 1 
ATOM   3309 N N   . LYS B 1 137 ? -39.09340 -15.53852 10.98759  1.000 38.52469 ? 137 LYS B N   1 
ATOM   3310 C CA  . LYS B 1 137 ? -38.10170 -16.60132 10.85478  1.000 43.23077 ? 137 LYS B CA  1 
ATOM   3311 C C   . LYS B 1 137 ? -36.87201 -16.15294 11.63290  1.000 43.38456 ? 137 LYS B C   1 
ATOM   3312 O O   . LYS B 1 137 ? -35.94017 -15.56509 11.08114  1.000 41.34139 ? 137 LYS B O   1 
ATOM   3313 C CB  . LYS B 1 137 ? -37.78772 -16.86827 9.38537   1.000 42.82871 ? 137 LYS B CB  1 
ATOM   3314 C CG  . LYS B 1 137 ? -38.93806 -17.49699 8.64005   1.000 44.33245 ? 137 LYS B CG  1 
ATOM   3315 C CD  . LYS B 1 137 ? -38.77165 -17.39516 7.12807   1.000 52.99160 ? 137 LYS B CD  1 
ATOM   3316 C CE  . LYS B 1 137 ? -39.81317 -18.25573 6.37445   1.000 55.44255 ? 137 LYS B CE  1 
ATOM   3317 N NZ  . LYS B 1 137 ? -39.76822 -18.01121 4.88611   1.000 62.94649 ? 137 LYS B NZ  1 
ATOM   3318 N N   . GLY B 1 138 ? -36.87690 -16.44249 12.93160  1.000 41.08916 ? 138 GLY B N   1 
ATOM   3319 C CA  . GLY B 1 138 ? -35.88123 -15.93746 13.84585  1.000 34.35728 ? 138 GLY B CA  1 
ATOM   3320 C C   . GLY B 1 138 ? -34.83879 -16.97585 14.21631  1.000 37.28983 ? 138 GLY B C   1 
ATOM   3321 O O   . GLY B 1 138 ? -34.69589 -18.02772 13.58945  1.000 44.13843 ? 138 GLY B O   1 
ATOM   3322 N N   . SER B 1 139 ? -34.08535 -16.65220 15.26112  1.000 37.44468 ? 139 SER B N   1 
ATOM   3323 C CA  . SER B 1 139 ? -33.11242 -17.57576 15.84187  1.000 41.37887 ? 139 SER B CA  1 
ATOM   3324 C C   . SER B 1 139 ? -33.20026 -17.36332 17.34585  1.000 41.21078 ? 139 SER B C   1 
ATOM   3325 O O   . SER B 1 139 ? -32.64805 -16.39732 17.88365  1.000 42.28112 ? 139 SER B O   1 
ATOM   3326 C CB  . SER B 1 139 ? -31.69989 -17.34751 15.31008  1.000 40.89553 ? 139 SER B CB  1 
ATOM   3327 O OG  . SER B 1 139 ? -30.75930 -18.11944 16.02677  1.000 39.11209 ? 139 SER B OG  1 
ATOM   3328 N N   . PHE B 1 140 ? -33.89219 -18.28571 18.00452  1.000 39.88608 ? 140 PHE B N   1 
ATOM   3329 C CA  . PHE B 1 140 ? -34.39575 -18.13515 19.36034  1.000 46.10866 ? 140 PHE B CA  1 
ATOM   3330 C C   . PHE B 1 140 ? -34.28445 -19.48212 20.05189  1.000 46.27372 ? 140 PHE B C   1 
ATOM   3331 O O   . PHE B 1 140 ? -34.81309 -20.47869 19.54903  1.000 40.02246 ? 140 PHE B O   1 
ATOM   3332 C CB  . PHE B 1 140 ? -35.86094 -17.69336 19.36838  1.000 40.74625 ? 140 PHE B CB  1 
ATOM   3333 C CG  . PHE B 1 140 ? -36.08357 -16.28668 18.91171  1.000 41.03279 ? 140 PHE B CG  1 
ATOM   3334 C CD1 . PHE B 1 140 ? -35.60327 -15.22374 19.65022  1.000 42.17459 ? 140 PHE B CD1 1 
ATOM   3335 C CD2 . PHE B 1 140 ? -36.80924 -16.02370 17.76455  1.000 40.02415 ? 140 PHE B CD2 1 
ATOM   3336 C CE1 . PHE B 1 140 ? -35.83280 -13.91628 19.24744  1.000 42.34803 ? 140 PHE B CE1 1 
ATOM   3337 C CE2 . PHE B 1 140 ? -37.03198 -14.72284 17.35581  1.000 43.37352 ? 140 PHE B CE2 1 
ATOM   3338 C CZ  . PHE B 1 140 ? -36.54906 -13.66982 18.10140  1.000 40.12543 ? 140 PHE B CZ  1 
ATOM   3339 N N   . LEU B 1 141 ? -33.58151 -19.51047 21.17593  1.000 45.45740 ? 141 LEU B N   1 
ATOM   3340 C CA  . LEU B 1 141 ? -33.41248 -20.70720 21.97871  1.000 50.23204 ? 141 LEU B CA  1 
ATOM   3341 C C   . LEU B 1 141 ? -34.16985 -20.54192 23.28946  1.000 50.84410 ? 141 LEU B C   1 
ATOM   3342 O O   . LEU B 1 141 ? -34.77571 -19.49775 23.56045  1.000 44.52068 ? 141 LEU B O   1 
ATOM   3343 C CB  . LEU B 1 141 ? -31.92368 -20.98115 22.23223  1.000 46.33686 ? 141 LEU B CB  1 
ATOM   3344 C CG  . LEU B 1 141 ? -31.03459 -21.21888 21.01081  1.000 50.38834 ? 141 LEU B CG  1 
ATOM   3345 C CD1 . LEU B 1 141 ? -29.56522 -21.23806 21.42811  1.000 48.83007 ? 141 LEU B CD1 1 
ATOM   3346 C CD2 . LEU B 1 141 ? -31.40485 -22.51432 20.29268  1.000 50.24450 ? 141 LEU B CD2 1 
ATOM   3347 N N   . ASN B 1 142 ? -34.14901 -21.59957 24.10199  1.000 53.38343 ? 142 ASN B N   1 
ATOM   3348 C CA  . ASN B 1 142 ? -34.67085 -21.49164 25.45715  1.000 50.82083 ? 142 ASN B CA  1 
ATOM   3349 C C   . ASN B 1 142 ? -34.01943 -20.31625 26.17217  1.000 51.03048 ? 142 ASN B C   1 
ATOM   3350 O O   . ASN B 1 142 ? -32.80702 -20.11633 26.09365  1.000 49.12250 ? 142 ASN B O   1 
ATOM   3351 C CB  . ASN B 1 142 ? -34.41775 -22.78486 26.23467  1.000 54.26115 ? 142 ASN B CB  1 
ATOM   3352 C CG  . ASN B 1 142 ? -35.41474 -23.85945 25.89847  1.000 61.56838 ? 142 ASN B CG  1 
ATOM   3353 O OD1 . ASN B 1 142 ? -36.61026 -23.58679 25.76392  1.000 62.30246 ? 142 ASN B OD1 1 
ATOM   3354 N ND2 . ASN B 1 142 ? -34.93478 -25.09200 25.75276  1.000 60.74317 ? 142 ASN B ND2 1 
ATOM   3355 N N   . GLY B 1 143 ? -34.83471 -19.53111 26.86785  1.000 46.53593 ? 143 GLY B N   1 
ATOM   3356 C CA  . GLY B 1 143 ? -34.33734 -18.37762 27.57413  1.000 49.73783 ? 143 GLY B CA  1 
ATOM   3357 C C   . GLY B 1 143 ? -34.40440 -17.08237 26.80183  1.000 46.00858 ? 143 GLY B C   1 
ATOM   3358 O O   . GLY B 1 143 ? -34.23175 -16.02461 27.40637  1.000 50.76687 ? 143 GLY B O   1 
ATOM   3359 N N   . SER B 1 144 ? -34.66515 -17.13162 25.48925  1.000 46.03196 ? 144 SER B N   1 
ATOM   3360 C CA  . SER B 1 144 ? -34.66129 -15.94401 24.63537  1.000 43.70145 ? 144 SER B CA  1 
ATOM   3361 C C   . SER B 1 144 ? -35.92945 -15.10548 24.75348  1.000 46.48865 ? 144 SER B C   1 
ATOM   3362 O O   . SER B 1 144 ? -35.96453 -13.99355 24.22042  1.000 39.33499 ? 144 SER B O   1 
ATOM   3363 C CB  . SER B 1 144 ? -34.47157 -16.35723 23.17010  1.000 44.37460 ? 144 SER B CB  1 
ATOM   3364 O OG  . SER B 1 144 ? -35.53664 -17.20138 22.73777  1.000 42.65717 ? 144 SER B OG  1 
ATOM   3365 N N   . CYS B 1 145 ? -36.97589 -15.59766 25.41641  1.000 38.56199 ? 145 CYS B N   1 
ATOM   3366 C CA  . CYS B 1 145 ? -38.20097 -14.81979 25.48286  1.000 41.88589 ? 145 CYS B CA  1 
ATOM   3367 C C   . CYS B 1 145 ? -37.94491 -13.48441 26.17365  1.000 40.62845 ? 145 CYS B C   1 
ATOM   3368 O O   . CYS B 1 145 ? -37.07273 -13.35842 27.03361  1.000 43.01255 ? 145 CYS B O   1 
ATOM   3369 C CB  . CYS B 1 145 ? -39.29741 -15.60458 26.20411  1.000 41.51250 ? 145 CYS B CB  1 
ATOM   3370 S SG  . CYS B 1 145 ? -40.09791 -16.84887 25.17641  1.000 46.16316 ? 145 CYS B SG  1 
ATOM   3371 N N   . GLY B 1 146 ? -38.73317 -12.48156 25.79788  1.000 37.86162 ? 146 GLY B N   1 
ATOM   3372 C CA  . GLY B 1 146 ? -38.50162 -11.13069 26.23204  1.000 39.15850 ? 146 GLY B CA  1 
ATOM   3373 C C   . GLY B 1 146 ? -37.55182 -10.34622 25.34786  1.000 39.73829 ? 146 GLY B C   1 
ATOM   3374 O O   . GLY B 1 146 ? -37.48922 -9.12290  25.47832  1.000 40.70812 ? 146 GLY B O   1 
ATOM   3375 N N   . SER B 1 147 ? -36.80859 -11.01235 24.46340  1.000 41.28485 ? 147 SER B N   1 
ATOM   3376 C CA  . SER B 1 147 ? -36.05438 -10.31044 23.42483  1.000 39.20167 ? 147 SER B CA  1 
ATOM   3377 C C   . SER B 1 147 ? -37.00739 -9.47350  22.57968  1.000 40.54608 ? 147 SER B C   1 
ATOM   3378 O O   . SER B 1 147 ? -38.14540 -9.87917  22.31577  1.000 41.54512 ? 147 SER B O   1 
ATOM   3379 C CB  . SER B 1 147 ? -35.31235 -11.30943 22.52983  1.000 41.69738 ? 147 SER B CB  1 
ATOM   3380 O OG  . SER B 1 147 ? -34.36994 -12.08556 23.25109  1.000 39.66080 ? 147 SER B OG  1 
ATOM   3381 N N   . VAL B 1 148 ? -36.54155 -8.30660  22.14902  1.000 39.34623 ? 148 VAL B N   1 
ATOM   3382 C CA  . VAL B 1 148 ? -37.37552 -7.35729  21.42496  1.000 41.56225 ? 148 VAL B CA  1 
ATOM   3383 C C   . VAL B 1 148 ? -36.86844 -7.18754  19.99476  1.000 38.04335 ? 148 VAL B C   1 
ATOM   3384 O O   . VAL B 1 148 ? -35.70987 -7.45690  19.66843  1.000 39.33435 ? 148 VAL B O   1 
ATOM   3385 C CB  . VAL B 1 148 ? -37.46466 -5.98728  22.14256  1.000 39.32793 ? 148 VAL B CB  1 
ATOM   3386 C CG1 . VAL B 1 148 ? -38.02212 -6.16286  23.54080  1.000 41.13464 ? 148 VAL B CG1 1 
ATOM   3387 C CG2 . VAL B 1 148 ? -36.12027 -5.27753  22.18736  1.000 38.41291 ? 148 VAL B CG2 1 
ATOM   3388 N N   . GLY B 1 149 ? -37.79071 -6.80392  19.12180  1.000 36.44528 ? 149 GLY B N   1 
ATOM   3389 C CA  . GLY B 1 149 ? -37.45834 -6.37818  17.78017  1.000 39.73572 ? 149 GLY B CA  1 
ATOM   3390 C C   . GLY B 1 149 ? -37.80511 -4.90681  17.66046  1.000 41.25120 ? 149 GLY B C   1 
ATOM   3391 O O   . GLY B 1 149 ? -38.69927 -4.40353  18.35098  1.000 38.87101 ? 149 GLY B O   1 
ATOM   3392 N N   . PHE B 1 150 ? -37.06086 -4.20190  16.81571  1.000 37.21316 ? 150 PHE B N   1 
ATOM   3393 C CA  . PHE B 1 150 ? -37.12345 -2.74992  16.88811  1.000 38.45344 ? 150 PHE B CA  1 
ATOM   3394 C C   . PHE B 1 150 ? -36.60989 -2.13940  15.59618  1.000 42.02907 ? 150 PHE B C   1 
ATOM   3395 O O   . PHE B 1 150 ? -35.87459 -2.77581  14.83434  1.000 36.15627 ? 150 PHE B O   1 
ATOM   3396 C CB  . PHE B 1 150 ? -36.31235 -2.21549  18.07716  1.000 37.84730 ? 150 PHE B CB  1 
ATOM   3397 C CG  . PHE B 1 150 ? -34.83810 -2.50350  17.98595  1.000 39.98288 ? 150 PHE B CG  1 
ATOM   3398 C CD1 . PHE B 1 150 ? -34.33223 -3.74364  18.37205  1.000 39.17466 ? 150 PHE B CD1 1 
ATOM   3399 C CD2 . PHE B 1 150 ? -33.95736 -1.53502  17.50615  1.000 39.83040 ? 150 PHE B CD2 1 
ATOM   3400 C CE1 . PHE B 1 150 ? -32.97454 -4.02049  18.28170  1.000 41.39935 ? 150 PHE B CE1 1 
ATOM   3401 C CE2 . PHE B 1 150 ? -32.59666 -1.78929  17.41780  1.000 41.19700 ? 150 PHE B CE2 1 
ATOM   3402 C CZ  . PHE B 1 150 ? -32.09782 -3.02961  17.80393  1.000 40.68741 ? 150 PHE B CZ  1 
ATOM   3403 N N   . ASN B 1 151 ? -37.01542 -0.88918  15.36615  1.000 40.46287 ? 151 ASN B N   1 
ATOM   3404 C CA  . ASN B 1 151 ? -36.41753 -0.02190  14.35943  1.000 43.67178 ? 151 ASN B CA  1 
ATOM   3405 C C   . ASN B 1 151 ? -35.92746 1.25392   15.03194  1.000 46.78056 ? 151 ASN B C   1 
ATOM   3406 O O   . ASN B 1 151 ? -36.37372 1.61296   16.12680  1.000 47.68009 ? 151 ASN B O   1 
ATOM   3407 C CB  . ASN B 1 151 ? -37.42042 0.30872   13.24551  1.000 41.89623 ? 151 ASN B CB  1 
ATOM   3408 C CG  . ASN B 1 151 ? -37.65196 -0.86735  12.30516  1.000 43.22439 ? 151 ASN B CG  1 
ATOM   3409 O OD1 . ASN B 1 151 ? -36.83848 -1.11726  11.40964  1.000 40.11036 ? 151 ASN B OD1 1 
ATOM   3410 N ND2 . ASN B 1 151 ? -38.76492 -1.58781  12.49093  1.000 35.59307 ? 151 ASN B ND2 1 
ATOM   3411 N N   . ILE B 1 152 ? -34.99272 1.93996   14.38358  1.000 45.86604 ? 152 ILE B N   1 
ATOM   3412 C CA  . ILE B 1 152 ? -34.50870 3.22263   14.87513  1.000 46.76969 ? 152 ILE B CA  1 
ATOM   3413 C C   . ILE B 1 152 ? -34.74494 4.28447   13.81284  1.000 53.06567 ? 152 ILE B C   1 
ATOM   3414 O O   . ILE B 1 152 ? -34.48872 4.06046   12.62428  1.000 51.28972 ? 152 ILE B O   1 
ATOM   3415 C CB  . ILE B 1 152 ? -33.02361 3.17636   15.26322  1.000 42.02783 ? 152 ILE B CB  1 
ATOM   3416 C CG1 . ILE B 1 152 ? -32.76976 2.07632   16.29496  1.000 46.02366 ? 152 ILE B CG1 1 
ATOM   3417 C CG2 . ILE B 1 152 ? -32.58896 4.53955   15.79195  1.000 45.67702 ? 152 ILE B CG2 1 
ATOM   3418 C CD1 . ILE B 1 152 ? -31.33101 2.05604   16.81315  1.000 47.60012 ? 152 ILE B CD1 1 
ATOM   3419 N N   . ASP B 1 153 ? -35.23409 5.44293   14.25182  1.000 54.36980 ? 153 ASP B N   1 
ATOM   3420 C CA  . ASP B 1 153 ? -35.49189 6.58636   13.38153  1.000 59.81703 ? 153 ASP B CA  1 
ATOM   3421 C C   . ASP B 1 153 ? -34.98688 7.82992   14.08646  1.000 58.40909 ? 153 ASP B C   1 
ATOM   3422 O O   . ASP B 1 153 ? -35.41925 8.12350   15.20654  1.000 61.03294 ? 153 ASP B O   1 
ATOM   3423 C CB  . ASP B 1 153 ? -36.98027 6.72439   13.06909  1.000 61.47602 ? 153 ASP B CB  1 
ATOM   3424 C CG  . ASP B 1 153 ? -37.51598 5.54494   12.29785  1.000 70.29867 ? 153 ASP B CG  1 
ATOM   3425 O OD1 . ASP B 1 153 ? -37.03617 5.33033   11.15906  1.000 74.06301 ? 153 ASP B OD1 1 
ATOM   3426 O OD2 . ASP B 1 153 ? -38.39230 4.82400   12.84121  1.000 63.12523 ? 153 ASP B OD2 1 
ATOM   3427 N N   . TYR B 1 154 ? -34.08643 8.55936   13.43503  1.000 58.16406 ? 154 TYR B N   1 
ATOM   3428 C CA  . TYR B 1 154 ? -33.37521 9.62105   14.12966  1.000 62.31993 ? 154 TYR B CA  1 
ATOM   3429 C C   . TYR B 1 154 ? -32.72989 9.01724   15.37351  1.000 59.86420 ? 154 TYR B C   1 
ATOM   3430 O O   . TYR B 1 154 ? -31.94056 8.07135   15.26613  1.000 62.66497 ? 154 TYR B O   1 
ATOM   3431 C CB  . TYR B 1 154 ? -34.32311 10.77242  14.47554  1.000 60.74289 ? 154 TYR B CB  1 
ATOM   3432 N N   . ASP B 1 155 ? -33.05927 9.52940   16.55875  1.000 56.21480 ? 155 ASP B N   1 
ATOM   3433 C CA  . ASP B 1 155 ? -32.54849 8.95362   17.79850  1.000 61.55571 ? 155 ASP B CA  1 
ATOM   3434 C C   . ASP B 1 155 ? -33.61470 8.14542   18.54371  1.000 55.24631 ? 155 ASP B C   1 
ATOM   3435 O O   . ASP B 1 155 ? -33.43623 7.83151   19.72732  1.000 55.01251 ? 155 ASP B O   1 
ATOM   3436 C CB  . ASP B 1 155 ? -31.97215 10.05265  18.69878  1.000 54.13358 ? 155 ASP B CB  1 
ATOM   3437 N N   . CYS B 1 156 ? -34.70576 7.78069   17.86395  1.000 53.06752 ? 156 CYS B N   1 
ATOM   3438 C CA  . CYS B 1 156 ? -35.88593 7.18251   18.48726  1.000 53.20669 ? 156 CYS B CA  1 
ATOM   3439 C C   . CYS B 1 156 ? -35.99036 5.69312   18.15274  1.000 52.98534 ? 156 CYS B C   1 
ATOM   3440 O O   . CYS B 1 156 ? -36.02444 5.31861   16.97337  1.000 49.15073 ? 156 CYS B O   1 
ATOM   3441 C CB  . CYS B 1 156 ? -37.14589 7.91761   18.02796  1.000 47.81388 ? 156 CYS B CB  1 
ATOM   3442 S SG  . CYS B 1 156 ? -38.66391 7.42861   18.87586  1.000 57.66156 ? 156 CYS B SG  1 
ATOM   3443 N N   . VAL B 1 157 ? -36.07167 4.85359   19.18889  1.000 47.97943 ? 157 VAL B N   1 
ATOM   3444 C CA  . VAL B 1 157 ? -36.28038 3.41392   19.03150  1.000 47.71033 ? 157 VAL B CA  1 
ATOM   3445 C C   . VAL B 1 157 ? -37.77721 3.13158   19.02392  1.000 48.64914 ? 157 VAL B C   1 
ATOM   3446 O O   . VAL B 1 157 ? -38.46853 3.38158   20.01592  1.000 43.50648 ? 157 VAL B O   1 
ATOM   3447 C CB  . VAL B 1 157 ? -35.59978 2.61855   20.15405  1.000 44.24896 ? 157 VAL B CB  1 
ATOM   3448 C CG1 . VAL B 1 157 ? -35.87386 1.10561   19.96371  1.000 41.39531 ? 157 VAL B CG1 1 
ATOM   3449 C CG2 . VAL B 1 157 ? -34.11946 2.93117   20.19630  1.000 44.27638 ? 157 VAL B CG2 1 
ATOM   3450 N N   . SER B 1 158 ? -38.28428 2.62805   17.90469  1.000 46.40802 ? 158 SER B N   1 
ATOM   3451 C CA  . SER B 1 158 ? -39.66086 2.15817   17.83151  1.000 45.33750 ? 158 SER B CA  1 
ATOM   3452 C C   . SER B 1 158 ? -39.63881 0.66436   18.10008  1.000 43.65332 ? 158 SER B C   1 
ATOM   3453 O O   . SER B 1 158 ? -39.28054 -0.12658  17.22381  1.000 41.46077 ? 158 SER B O   1 
ATOM   3454 C CB  . SER B 1 158 ? -40.28754 2.46549   16.47832  1.000 44.28376 ? 158 SER B CB  1 
ATOM   3455 O OG  . SER B 1 158 ? -40.49157 3.85506   16.31884  1.000 51.81809 ? 158 SER B OG  1 
ATOM   3456 N N   . PHE B 1 159 ? -40.01211 0.27651   19.32192  1.000 44.30359 ? 159 PHE B N   1 
ATOM   3457 C CA  . PHE B 1 159 ? -40.16859 -1.13723  19.63998  1.000 43.40628 ? 159 PHE B CA  1 
ATOM   3458 C C   . PHE B 1 159 ? -41.41826 -1.67697  18.97144  1.000 39.71708 ? 159 PHE B C   1 
ATOM   3459 O O   . PHE B 1 159 ? -42.49961 -1.09215  19.09313  1.000 41.18241 ? 159 PHE B O   1 
ATOM   3460 C CB  . PHE B 1 159 ? -40.25120 -1.35187  21.14802  1.000 42.05292 ? 159 PHE B CB  1 
ATOM   3461 C CG  . PHE B 1 159 ? -38.99913 -0.99400  21.87550  1.000 40.09728 ? 159 PHE B CG  1 
ATOM   3462 C CD1 . PHE B 1 159 ? -37.89582 -1.83798  21.83315  1.000 41.58958 ? 159 PHE B CD1 1 
ATOM   3463 C CD2 . PHE B 1 159 ? -38.91435 0.18622   22.59853  1.000 41.05448 ? 159 PHE B CD2 1 
ATOM   3464 C CE1 . PHE B 1 159 ? -36.71784 -1.50899  22.49457  1.000 37.21618 ? 159 PHE B CE1 1 
ATOM   3465 C CE2 . PHE B 1 159 ? -37.74344 0.51979   23.26554  1.000 42.41393 ? 159 PHE B CE2 1 
ATOM   3466 C CZ  . PHE B 1 159 ? -36.64506 -0.33598  23.21543  1.000 41.31842 ? 159 PHE B CZ  1 
ATOM   3467 N N   . CYS B 1 160 ? -41.27483 -2.79905  18.26656  1.000 40.21304 ? 160 CYS B N   1 
ATOM   3468 C CA  . CYS B 1 160 ? -42.39985 -3.39154  17.57224  1.000 41.27887 ? 160 CYS B CA  1 
ATOM   3469 C C   . CYS B 1 160 ? -42.66477 -4.85507  17.91880  1.000 37.57999 ? 160 CYS B C   1 
ATOM   3470 O O   . CYS B 1 160 ? -43.72120 -5.35839  17.53874  1.000 39.72925 ? 160 CYS B O   1 
ATOM   3471 C CB  . CYS B 1 160 ? -42.22301 -3.26573  16.04651  1.000 41.90891 ? 160 CYS B CB  1 
ATOM   3472 S SG  . CYS B 1 160 ? -40.80047 -4.13316  15.35852  1.000 42.62681 ? 160 CYS B SG  1 
ATOM   3473 N N   . TYR B 1 161 ? -41.77291 -5.54843  18.62695  1.000 38.10294 ? 161 TYR B N   1 
ATOM   3474 C CA  . TYR B 1 161 ? -41.96706 -6.98537  18.82016  1.000 40.09587 ? 161 TYR B CA  1 
ATOM   3475 C C   . TYR B 1 161 ? -41.33931 -7.43784  20.12720  1.000 37.88173 ? 161 TYR B C   1 
ATOM   3476 O O   . TYR B 1 161 ? -40.28513 -6.93796  20.51798  1.000 37.03076 ? 161 TYR B O   1 
ATOM   3477 C CB  . TYR B 1 161 ? -41.35125 -7.76094  17.64520  1.000 43.00614 ? 161 TYR B CB  1 
ATOM   3478 C CG  . TYR B 1 161 ? -41.39349 -9.26603  17.73558  1.000 35.87762 ? 161 TYR B CG  1 
ATOM   3479 C CD1 . TYR B 1 161 ? -42.45998 -9.97241  17.20924  1.000 37.91504 ? 161 TYR B CD1 1 
ATOM   3480 C CD2 . TYR B 1 161 ? -40.35011 -9.98181  18.31046  1.000 38.09654 ? 161 TYR B CD2 1 
ATOM   3481 C CE1 . TYR B 1 161 ? -42.50619 -11.33603 17.26489  1.000 37.73056 ? 161 TYR B CE1 1 
ATOM   3482 C CE2 . TYR B 1 161 ? -40.38060 -11.34626 18.37004  1.000 34.11331 ? 161 TYR B CE2 1 
ATOM   3483 C CZ  . TYR B 1 161 ? -41.46452 -12.02532 17.84288  1.000 35.87444 ? 161 TYR B CZ  1 
ATOM   3484 O OH  . TYR B 1 161 ? -41.53949 -13.39991 17.87863  1.000 32.78794 ? 161 TYR B OH  1 
ATOM   3485 N N   . MET B 1 162 ? -41.99873 -8.38449  20.80138  1.000 41.54524 ? 162 MET B N   1 
ATOM   3486 C CA  . MET B 1 162 ? -41.41106 -9.09477  21.92697  1.000 40.19417 ? 162 MET B CA  1 
ATOM   3487 C C   . MET B 1 162 ? -41.63303 -10.58022 21.70273  1.000 35.70607 ? 162 MET B C   1 
ATOM   3488 O O   . MET B 1 162 ? -42.72854 -10.99938 21.32130  1.000 39.18560 ? 162 MET B O   1 
ATOM   3489 C CB  . MET B 1 162 ? -42.01411 -8.65728  23.27899  1.000 38.14068 ? 162 MET B CB  1 
ATOM   3490 C CG  . MET B 1 162 ? -41.36481 -9.32735  24.50784  1.000 40.34657 ? 162 MET B CG  1 
ATOM   3491 S SD  . MET B 1 162 ? -41.95779 -8.72159  26.13775  1.000 50.31576 ? 162 MET B SD  1 
ATOM   3492 C CE  . MET B 1 162 ? -40.73347 -7.46717  26.49776  1.000 41.80341 ? 162 MET B CE  1 
ATOM   3493 N N   . HIS B 1 163 ? -40.58609 -11.37008 21.92653  1.000 32.87670 ? 163 HIS B N   1 
ATOM   3494 C CA  . HIS B 1 163 ? -40.62284 -12.78728 21.61101  1.000 34.75594 ? 163 HIS B CA  1 
ATOM   3495 C C   . HIS B 1 163 ? -41.31600 -13.59110 22.71095  1.000 38.72789 ? 163 HIS B C   1 
ATOM   3496 O O   . HIS B 1 163 ? -41.03573 -13.39710 23.89684  1.000 37.61769 ? 163 HIS B O   1 
ATOM   3497 C CB  . HIS B 1 163 ? -39.20417 -13.31284 21.42107  1.000 32.78496 ? 163 HIS B CB  1 
ATOM   3498 C CG  . HIS B 1 163 ? -39.16355 -14.72185 20.93957  1.000 36.47672 ? 163 HIS B CG  1 
ATOM   3499 N ND1 . HIS B 1 163 ? -39.90016 -15.15468 19.85733  1.000 35.60436 ? 163 HIS B ND1 1 
ATOM   3500 C CD2 . HIS B 1 163 ? -38.51580 -15.80887 21.41468  1.000 39.14189 ? 163 HIS B CD2 1 
ATOM   3501 C CE1 . HIS B 1 163 ? -39.69870 -16.44541 19.68087  1.000 36.37620 ? 163 HIS B CE1 1 
ATOM   3502 N NE2 . HIS B 1 163 ? -38.86347 -16.86730 20.61254  1.000 37.66404 ? 163 HIS B NE2 1 
ATOM   3503 N N   . HIS B 1 164 ? -42.19120 -14.52833 22.30626  1.000 37.25588 ? 164 HIS B N   1 
ATOM   3504 C CA  . HIS B 1 164 ? -42.89576 -15.39446 23.26281  1.000 38.50115 ? 164 HIS B CA  1 
ATOM   3505 C C   . HIS B 1 164 ? -42.77337 -16.87995 22.96661  1.000 42.07665 ? 164 HIS B C   1 
ATOM   3506 O O   . HIS B 1 164 ? -42.86201 -17.68275 23.89953  1.000 47.23577 ? 164 HIS B O   1 
ATOM   3507 C CB  . HIS B 1 164 ? -44.39250 -15.10721 23.31716  1.000 36.24032 ? 164 HIS B CB  1 
ATOM   3508 C CG  . HIS B 1 164 ? -44.75377 -13.79469 23.93349  1.000 39.40484 ? 164 HIS B CG  1 
ATOM   3509 N ND1 . HIS B 1 164 ? -45.58940 -13.69519 25.02609  1.000 40.86068 ? 164 HIS B ND1 1 
ATOM   3510 C CD2 . HIS B 1 164 ? -44.43672 -12.52520 23.58491  1.000 38.92808 ? 164 HIS B CD2 1 
ATOM   3511 C CE1 . HIS B 1 164 ? -45.75893 -12.42172 25.33341  1.000 41.81980 ? 164 HIS B CE1 1 
ATOM   3512 N NE2 . HIS B 1 164 ? -45.06808 -11.69098 24.47421  1.000 41.88901 ? 164 HIS B NE2 1 
ATOM   3513 N N   . MET B 1 165 ? -42.62511 -17.28598 21.70241  1.000 40.19944 ? 165 MET B N   1 
ATOM   3514 C CA  . MET B 1 165 ? -42.74916 -18.71834 21.44093  1.000 45.49432 ? 165 MET B CA  1 
ATOM   3515 C C   . MET B 1 165 ? -42.24051 -19.09600 20.06146  1.000 43.89783 ? 165 MET B C   1 
ATOM   3516 O O   . MET B 1 165 ? -42.13200 -18.26444 19.16261  1.000 41.65453 ? 165 MET B O   1 
ATOM   3517 C CB  . MET B 1 165 ? -44.19682 -19.17921 21.57575  1.000 45.41293 ? 165 MET B CB  1 
ATOM   3518 C CG  . MET B 1 165 ? -45.16540 -18.55895 20.58186  1.000 46.41936 ? 165 MET B CG  1 
ATOM   3519 S SD  . MET B 1 165 ? -46.88767 -19.10351 20.87389  1.000 60.14934 ? 165 MET B SD  1 
ATOM   3520 C CE  . MET B 1 165 ? -46.85541 -20.81150 20.34782  1.000 54.14536 ? 165 MET B CE  1 
ATOM   3521 N N   . GLU B 1 166 ? -41.94378 -20.38349 19.92128  1.000 41.14468 ? 166 GLU B N   1 
ATOM   3522 C CA  . GLU B 1 166 ? -41.59856 -21.01603 18.65945  1.000 42.19497 ? 166 GLU B CA  1 
ATOM   3523 C C   . GLU B 1 166 ? -42.67720 -22.01438 18.27309  1.000 47.24345 ? 166 GLU B C   1 
ATOM   3524 O O   . GLU B 1 166 ? -43.07004 -22.85165 19.09000  1.000 48.48170 ? 166 GLU B O   1 
ATOM   3525 C CB  . GLU B 1 166 ? -40.25572 -21.72549 18.77485  1.000 43.65402 ? 166 GLU B CB  1 
ATOM   3526 C CG  . GLU B 1 166 ? -39.91590 -22.60084 17.60114  1.000 43.60569 ? 166 GLU B CG  1 
ATOM   3527 C CD  . GLU B 1 166 ? -38.47259 -23.01169 17.63703  1.000 48.20126 ? 166 GLU B CD  1 
ATOM   3528 O OE1 . GLU B 1 166 ? -37.62510 -22.18638 18.05560  1.000 41.83348 ? 166 GLU B OE1 1 
ATOM   3529 O OE2 . GLU B 1 166 ? -38.18288 -24.16022 17.26499  1.000 50.61823 ? 166 GLU B OE2 1 
ATOM   3530 N N   . LEU B 1 167 ? -43.14113 -21.93953 17.03247  1.000 47.15048 ? 167 LEU B N   1 
ATOM   3531 C CA  . LEU B 1 167 ? -44.14570 -22.86495 16.54858  1.000 44.84014 ? 167 LEU B CA  1 
ATOM   3532 C C   . LEU B 1 167 ? -43.50623 -24.19628 16.19617  1.000 51.36738 ? 167 LEU B C   1 
ATOM   3533 O O   . LEU B 1 167 ? -42.28013 -24.31282 16.14156  1.000 47.75256 ? 167 LEU B O   1 
ATOM   3534 C CB  . LEU B 1 167 ? -44.85744 -22.27851 15.34028  1.000 42.74551 ? 167 LEU B CB  1 
ATOM   3535 C CG  . LEU B 1 167 ? -45.52344 -20.94542 15.64039  1.000 39.85771 ? 167 LEU B CG  1 
ATOM   3536 C CD1 . LEU B 1 167 ? -46.36648 -20.52853 14.45921  1.000 42.65457 ? 167 LEU B CD1 1 
ATOM   3537 C CD2 . LEU B 1 167 ? -46.36799 -21.06866 16.89553  1.000 49.47781 ? 167 LEU B CD2 1 
ATOM   3538 N N   . PRO B 1 168 ? -44.32833 -25.23133 15.96291  1.000 52.22052 ? 168 PRO B N   1 
ATOM   3539 C CA  . PRO B 1 168 ? -43.77435 -26.54532 15.59890  1.000 47.19951 ? 168 PRO B CA  1 
ATOM   3540 C C   . PRO B 1 168 ? -42.97260 -26.53237 14.31309  1.000 52.13347 ? 168 PRO B C   1 
ATOM   3541 O O   . PRO B 1 168 ? -41.99978 -27.28773 14.19830  1.000 51.21628 ? 168 PRO B O   1 
ATOM   3542 C CB  . PRO B 1 168 ? -45.02529 -27.42948 15.47456  1.000 52.29935 ? 168 PRO B CB  1 
ATOM   3543 C CG  . PRO B 1 168 ? -46.04648 -26.76560 16.34154  1.000 52.83681 ? 168 PRO B CG  1 
ATOM   3544 C CD  . PRO B 1 168 ? -45.78474 -25.28054 16.16116  1.000 49.41973 ? 168 PRO B CD  1 
ATOM   3545 N N   . THR B 1 169 ? -43.34977 -25.70989 13.33231  1.000 51.83550 ? 169 THR B N   1 
ATOM   3546 C CA  . THR B 1 169 ? -42.56036 -25.62373 12.10905  1.000 53.14231 ? 169 THR B CA  1 
ATOM   3547 C C   . THR B 1 169 ? -41.22480 -24.91079 12.30377  1.000 50.74281 ? 169 THR B C   1 
ATOM   3548 O O   . THR B 1 169 ? -40.42742 -24.85374 11.36332  1.000 50.06784 ? 169 THR B O   1 
ATOM   3549 C CB  . THR B 1 169 ? -43.36692 -24.92632 11.01446  1.000 57.21961 ? 169 THR B CB  1 
ATOM   3550 O OG1 . THR B 1 169 ? -43.62307 -23.55683 11.38757  1.000 48.27781 ? 169 THR B OG1 1 
ATOM   3551 C CG2 . THR B 1 169 ? -44.67840 -25.67583 10.80530  1.000 52.57763 ? 169 THR B CG2 1 
ATOM   3552 N N   . GLY B 1 170 ? -40.93424 -24.38260 13.48319  1.000 49.85447 ? 170 GLY B N   1 
ATOM   3553 C CA  . GLY B 1 170 ? -39.65879 -23.74545 13.71466  1.000 50.58675 ? 170 GLY B CA  1 
ATOM   3554 C C   . GLY B 1 170 ? -39.64636 -22.24575 13.50311  1.000 46.76604 ? 170 GLY B C   1 
ATOM   3555 O O   . GLY B 1 170 ? -38.61712 -21.61887 13.75636  1.000 42.20495 ? 170 GLY B O   1 
ATOM   3556 N N   . VAL B 1 171 ? -40.74993 -21.65273 13.04702  1.000 44.35596 ? 171 VAL B N   1 
ATOM   3557 C CA  . VAL B 1 171 ? -40.81680 -20.19720 12.96072  1.000 42.66812 ? 171 VAL B CA  1 
ATOM   3558 C C   . VAL B 1 171 ? -41.26379 -19.66190 14.31643  1.000 46.41170 ? 171 VAL B C   1 
ATOM   3559 O O   . VAL B 1 171 ? -41.60010 -20.43070 15.22839  1.000 39.92318 ? 171 VAL B O   1 
ATOM   3560 C CB  . VAL B 1 171 ? -41.75289 -19.72306 11.83050  1.000 45.38528 ? 171 VAL B CB  1 
ATOM   3561 C CG1 . VAL B 1 171 ? -41.17711 -20.11703 10.46652  1.000 46.62504 ? 171 VAL B CG1 1 
ATOM   3562 C CG2 . VAL B 1 171 ? -43.17859 -20.26740 12.01773  1.000 39.79376 ? 171 VAL B CG2 1 
ATOM   3563 N N   . HIS B 1 172 ? -41.29154 -18.34373 14.45333  1.000 39.65583 ? 172 HIS B N   1 
ATOM   3564 C CA  . HIS B 1 172 ? -41.38868 -17.72431 15.75847  1.000 40.09730 ? 172 HIS B CA  1 
ATOM   3565 C C   . HIS B 1 172 ? -42.57710 -16.77380 15.81895  1.000 39.34879 ? 172 HIS B C   1 
ATOM   3566 O O   . HIS B 1 172 ? -43.08342 -16.30733 14.79519  1.000 40.51712 ? 172 HIS B O   1 
ATOM   3567 C CB  . HIS B 1 172 ? -40.07316 -17.03043 16.07823  1.000 38.60163 ? 172 HIS B CB  1 
ATOM   3568 C CG  . HIS B 1 172 ? -38.92272 -17.98079 16.19495  1.000 41.51651 ? 172 HIS B CG  1 
ATOM   3569 N ND1 . HIS B 1 172 ? -37.94705 -18.10351 15.22303  1.000 38.90807 ? 172 HIS B ND1 1 
ATOM   3570 C CD2 . HIS B 1 172 ? -38.60603 -18.87606 17.16196  1.000 41.23591 ? 172 HIS B CD2 1 
ATOM   3571 C CE1 . HIS B 1 172 ? -37.06451 -19.01244 15.60103  1.000 42.02933 ? 172 HIS B CE1 1 
ATOM   3572 N NE2 . HIS B 1 172 ? -37.44374 -19.49932 16.77202  1.000 44.14480 ? 172 HIS B NE2 1 
ATOM   3573 N N   . ALA B 1 173 ? -43.05111 -16.52115 17.03633  1.000 32.76167 ? 173 ALA B N   1 
ATOM   3574 C CA  . ALA B 1 173 ? -44.25736 -15.72217 17.22520  1.000 35.05155 ? 173 ALA B CA  1 
ATOM   3575 C C   . ALA B 1 173 ? -44.12858 -14.89650 18.49473  1.000 37.15169 ? 173 ALA B C   1 
ATOM   3576 O O   . ALA B 1 173 ? -43.37518 -15.23109 19.40824  1.000 39.96844 ? 173 ALA B O   1 
ATOM   3577 C CB  . ALA B 1 173 ? -45.52635 -16.60135 17.28093  1.000 39.97960 ? 173 ALA B CB  1 
ATOM   3578 N N   . GLY B 1 174 ? -44.87765 -13.80645 18.54425  1.000 35.12050 ? 174 GLY B N   1 
ATOM   3579 C CA  . GLY B 1 174 ? -44.81566 -12.93782 19.69374  1.000 36.59637 ? 174 GLY B CA  1 
ATOM   3580 C C   . GLY B 1 174 ? -45.76692 -11.78114 19.53254  1.000 35.14290 ? 174 GLY B C   1 
ATOM   3581 O O   . GLY B 1 174 ? -46.65762 -11.80024 18.67869  1.000 40.57208 ? 174 GLY B O   1 
ATOM   3582 N N   . THR B 1 175 ? -45.56135 -10.76624 20.35647  1.000 34.96479 ? 175 THR B N   1 
ATOM   3583 C CA  . THR B 1 175 ? -46.54134 -9.70695  20.52230  1.000 39.83454 ? 175 THR B CA  1 
ATOM   3584 C C   . THR B 1 175 ? -45.90413 -8.37144  20.19406  1.000 39.43541 ? 175 THR B C   1 
ATOM   3585 O O   . THR B 1 175 ? -44.67851 -8.25920  20.10353  1.000 42.68198 ? 175 THR B O   1 
ATOM   3586 C CB  . THR B 1 175 ? -47.08303 -9.67897  21.95789  1.000 41.78027 ? 175 THR B CB  1 
ATOM   3587 O OG1 . THR B 1 175 ? -46.06455 -9.19586  22.85411  1.000 37.94472 ? 175 THR B OG1 1 
ATOM   3588 C CG2 . THR B 1 175 ? -47.51616 -11.09543 22.37900  1.000 39.72992 ? 175 THR B CG2 1 
ATOM   3589 N N   . ASP B 1 176 ? -46.75182 -7.35853  20.01159  1.000 38.39242 ? 176 ASP B N   1 
ATOM   3590 C CA  . ASP B 1 176 ? -46.26578 -5.98769  20.11640  1.000 40.42233 ? 176 ASP B CA  1 
ATOM   3591 C C   . ASP B 1 176 ? -45.99232 -5.68133  21.59138  1.000 44.19628 ? 176 ASP B C   1 
ATOM   3592 O O   . ASP B 1 176 ? -46.16360 -6.52988  22.47568  1.000 43.05725 ? 176 ASP B O   1 
ATOM   3593 C CB  . ASP B 1 176 ? -47.26353 -5.00579  19.48546  1.000 38.54754 ? 176 ASP B CB  1 
ATOM   3594 C CG  . ASP B 1 176 ? -48.63026 -5.00201  20.18033  1.000 45.76298 ? 176 ASP B CG  1 
ATOM   3595 O OD1 . ASP B 1 176 ? -48.70102 -5.30825  21.38872  1.000 41.02862 ? 176 ASP B OD1 1 
ATOM   3596 O OD2 . ASP B 1 176 ? -49.64123 -4.68914  19.51166  1.000 43.81542 ? 176 ASP B OD2 1 
ATOM   3597 N N   . LEU B 1 177 ? -45.58121 -4.45403  21.86985  1.000 38.51551 ? 177 LEU B N   1 
ATOM   3598 C CA  . LEU B 1 177 ? -45.19138 -4.09596  23.22833  1.000 43.09746 ? 177 LEU B CA  1 
ATOM   3599 C C   . LEU B 1 177 ? -46.37983 -3.78382  24.12670  1.000 41.67136 ? 177 LEU B C   1 
ATOM   3600 O O   . LEU B 1 177 ? -46.17119 -3.50703  25.30916  1.000 44.32125 ? 177 LEU B O   1 
ATOM   3601 C CB  . LEU B 1 177 ? -44.21448 -2.90002  23.21571  1.000 31.93627 ? 177 LEU B CB  1 
ATOM   3602 C CG  . LEU B 1 177 ? -42.75583 -3.34170  23.09422  1.000 39.76674 ? 177 LEU B CG  1 
ATOM   3603 C CD1 . LEU B 1 177 ? -42.26464 -3.97082  24.37005  1.000 36.30980 ? 177 LEU B CD1 1 
ATOM   3604 C CD2 . LEU B 1 177 ? -42.58068 -4.31399  21.92630  1.000 37.03470 ? 177 LEU B CD2 1 
ATOM   3605 N N   . GLU B 1 178 ? -47.59745 -3.79048  23.58939  1.000 42.61885 ? 178 GLU B N   1 
ATOM   3606 C CA  . GLU B 1 178 ? -48.81689 -3.74725  24.38257  1.000 45.37537 ? 178 GLU B CA  1 
ATOM   3607 C C   . GLU B 1 178 ? -49.40163 -5.13117  24.63392  1.000 43.03051 ? 178 GLU B C   1 
ATOM   3608 O O   . GLU B 1 178 ? -50.49383 -5.23174  25.19917  1.000 44.26469 ? 178 GLU B O   1 
ATOM   3609 C CB  . GLU B 1 178 ? -49.85640 -2.85213  23.70139  1.000 41.96556 ? 178 GLU B CB  1 
ATOM   3610 C CG  . GLU B 1 178 ? -49.40403 -1.38168  23.59875  1.000 49.66761 ? 178 GLU B CG  1 
ATOM   3611 C CD  . GLU B 1 178 ? -50.50512 -0.47609  23.09535  1.000 54.31902 ? 178 GLU B CD  1 
ATOM   3612 O OE1 . GLU B 1 178 ? -51.39395 -0.97806  22.36653  1.000 55.57741 ? 178 GLU B OE1 1 
ATOM   3613 O OE2 . GLU B 1 178 ? -50.48711 0.72781   23.43883  1.000 52.87716 ? 178 GLU B OE2 1 
ATOM   3614 N N   . GLY B 1 179 ? -48.70461 -6.19070  24.23000  1.000 41.48730 ? 179 GLY B N   1 
ATOM   3615 C CA  . GLY B 1 179 ? -49.06045 -7.54708  24.57728  1.000 40.10015 ? 179 GLY B CA  1 
ATOM   3616 C C   . GLY B 1 179 ? -49.95209 -8.27998  23.60192  1.000 45.53990 ? 179 GLY B C   1 
ATOM   3617 O O   . GLY B 1 179 ? -50.22378 -9.46912  23.81879  1.000 47.10357 ? 179 GLY B O   1 
ATOM   3618 N N   . ASN B 1 180 ? -50.42363 -7.62263  22.54624  1.000 43.42639 ? 180 ASN B N   1 
ATOM   3619 C CA  . ASN B 1 180 ? -51.25215 -8.27518  21.53674  1.000 38.93733 ? 180 ASN B CA  1 
ATOM   3620 C C   . ASN B 1 180 ? -50.37558 -9.07512  20.58317  1.000 43.70158 ? 180 ASN B C   1 
ATOM   3621 O O   . ASN B 1 180 ? -49.45394 -8.52303  19.96625  1.000 41.54350 ? 180 ASN B O   1 
ATOM   3622 C CB  . ASN B 1 180 ? -52.06410 -7.24067  20.76280  1.000 42.67387 ? 180 ASN B CB  1 
ATOM   3623 C CG  . ASN B 1 180 ? -52.95010 -6.40994  21.66517  1.000 47.05268 ? 180 ASN B CG  1 
ATOM   3624 O OD1 . ASN B 1 180 ? -52.88602 -5.18195  21.65858  1.000 54.35255 ? 180 ASN B OD1 1 
ATOM   3625 N ND2 . ASN B 1 180 ? -53.76689 -7.07898  22.46177  1.000 38.78412 ? 180 ASN B ND2 1 
ATOM   3626 N N   . PHE B 1 181 ? -50.65936 -10.37176 20.47256  1.000 43.90793 ? 181 PHE B N   1 
ATOM   3627 C CA  . PHE B 1 181 ? -49.95347 -11.22569 19.52611  1.000 41.11745 ? 181 PHE B CA  1 
ATOM   3628 C C   . PHE B 1 181 ? -50.06277 -10.68537 18.10896  1.000 42.80170 ? 181 PHE B C   1 
ATOM   3629 O O   . PHE B 1 181 ? -51.09596 -10.13807 17.70898  1.000 41.26661 ? 181 PHE B O   1 
ATOM   3630 C CB  . PHE B 1 181 ? -50.51106 -12.65541 19.57278  1.000 39.23966 ? 181 PHE B CB  1 
ATOM   3631 C CG  . PHE B 1 181 ? -49.68548 -13.56991 20.40394  1.000 41.43578 ? 181 PHE B CG  1 
ATOM   3632 C CD1 . PHE B 1 181 ? -49.87720 -13.63520 21.77284  1.000 40.60620 ? 181 PHE B CD1 1 
ATOM   3633 C CD2 . PHE B 1 181 ? -48.65889 -14.29628 19.83574  1.000 40.28155 ? 181 PHE B CD2 1 
ATOM   3634 C CE1 . PHE B 1 181 ? -49.09228 -14.43899 22.55955  1.000 41.93717 ? 181 PHE B CE1 1 
ATOM   3635 C CE2 . PHE B 1 181 ? -47.86030 -15.10549 20.61350  1.000 42.01989 ? 181 PHE B CE2 1 
ATOM   3636 C CZ  . PHE B 1 181 ? -48.08582 -15.18408 21.98145  1.000 46.64477 ? 181 PHE B CZ  1 
ATOM   3637 N N   . TYR B 1 182 ? -48.98243 -10.83951 17.34769  1.000 41.34023 ? 182 TYR B N   1 
ATOM   3638 C CA  . TYR B 1 182 ? -49.09563 -10.81982 15.90038  1.000 38.16360 ? 182 TYR B CA  1 
ATOM   3639 C C   . TYR B 1 182 ? -49.62017 -12.18316 15.47745  1.000 38.45667 ? 182 TYR B C   1 
ATOM   3640 O O   . TYR B 1 182 ? -49.04522 -13.21074 15.84827  1.000 37.77578 ? 182 TYR B O   1 
ATOM   3641 C CB  . TYR B 1 182 ? -47.74105 -10.50650 15.25036  1.000 36.94501 ? 182 TYR B CB  1 
ATOM   3642 C CG  . TYR B 1 182 ? -47.26792 -9.09531  15.50162  1.000 36.67963 ? 182 TYR B CG  1 
ATOM   3643 C CD1 . TYR B 1 182 ? -47.77241 -8.02894  14.75999  1.000 40.98026 ? 182 TYR B CD1 1 
ATOM   3644 C CD2 . TYR B 1 182 ? -46.30189 -8.82096  16.46357  1.000 39.67578 ? 182 TYR B CD2 1 
ATOM   3645 C CE1 . TYR B 1 182 ? -47.32994 -6.70750  14.98210  1.000 40.27032 ? 182 TYR B CE1 1 
ATOM   3646 C CE2 . TYR B 1 182 ? -45.84397 -7.51196  16.68550  1.000 36.68611 ? 182 TYR B CE2 1 
ATOM   3647 C CZ  . TYR B 1 182 ? -46.37995 -6.46908  15.95140  1.000 39.15644 ? 182 TYR B CZ  1 
ATOM   3648 O OH  . TYR B 1 182 ? -45.95651 -5.19300  16.18191  1.000 40.73084 ? 182 TYR B OH  1 
ATOM   3649 N N   . GLY B 1 183 ? -50.72574 -12.20445 14.73545  1.000 38.70291 ? 183 GLY B N   1 
ATOM   3650 C CA  . GLY B 1 183 ? -51.26370 -13.44457 14.24050  1.000 38.60063 ? 183 GLY B CA  1 
ATOM   3651 C C   . GLY B 1 183 ? -52.19498 -14.11338 15.24285  1.000 39.20057 ? 183 GLY B C   1 
ATOM   3652 O O   . GLY B 1 183 ? -52.34652 -13.66551 16.38597  1.000 39.06518 ? 183 GLY B O   1 
ATOM   3653 N N   . PRO B 1 184 ? -52.81685 -15.20506 14.82869  1.000 39.06748 ? 184 PRO B N   1 
ATOM   3654 C CA  . PRO B 1 184 ? -53.81581 -15.90718 15.67336  1.000 41.08969 ? 184 PRO B CA  1 
ATOM   3655 C C   . PRO B 1 184 ? -53.17423 -16.92569 16.60852  1.000 45.50495 ? 184 PRO B C   1 
ATOM   3656 O O   . PRO B 1 184 ? -53.42386 -18.13336 16.52078  1.000 52.33392 ? 184 PRO B O   1 
ATOM   3657 C CB  . PRO B 1 184 ? -54.69188 -16.59901 14.62674  1.000 43.06082 ? 184 PRO B CB  1 
ATOM   3658 C CG  . PRO B 1 184 ? -53.66581 -17.05013 13.61032  1.000 45.47566 ? 184 PRO B CG  1 
ATOM   3659 C CD  . PRO B 1 184 ? -52.69443 -15.83421 13.50151  1.000 42.23880 ? 184 PRO B CD  1 
ATOM   3660 N N   . PHE B 1 185 ? -52.32969 -16.44764 17.50396  1.000 44.14762 ? 185 PHE B N   1 
ATOM   3661 C CA  . PHE B 1 185 ? -51.61350 -17.32443 18.40612  1.000 42.84998 ? 185 PHE B CA  1 
ATOM   3662 C C   . PHE B 1 185 ? -51.93411 -16.91977 19.83953  1.000 48.40947 ? 185 PHE B C   1 
ATOM   3663 O O   . PHE B 1 185 ? -52.41857 -15.81558 20.09845  1.000 47.44505 ? 185 PHE B O   1 
ATOM   3664 C CB  . PHE B 1 185 ? -50.10038 -17.27509 18.13168  1.000 44.64630 ? 185 PHE B CB  1 
ATOM   3665 C CG  . PHE B 1 185 ? -49.73817 -17.49564 16.67545  1.000 45.07590 ? 185 PHE B CG  1 
ATOM   3666 C CD1 . PHE B 1 185 ? -49.86981 -18.75105 16.08684  1.000 42.99098 ? 185 PHE B CD1 1 
ATOM   3667 C CD2 . PHE B 1 185 ? -49.26468 -16.44343 15.90027  1.000 45.22698 ? 185 PHE B CD2 1 
ATOM   3668 C CE1 . PHE B 1 185 ? -49.56323 -18.95226 14.75134  1.000 41.78985 ? 185 PHE B CE1 1 
ATOM   3669 C CE2 . PHE B 1 185 ? -48.93753 -16.63255 14.56354  1.000 41.81074 ? 185 PHE B CE2 1 
ATOM   3670 C CZ  . PHE B 1 185 ? -49.08780 -17.88212 13.98492  1.000 44.50009 ? 185 PHE B CZ  1 
ATOM   3671 N N   . VAL B 1 186 ? -51.68181 -17.83593 20.77422  1.000 43.30962 ? 186 VAL B N   1 
ATOM   3672 C CA  . VAL B 1 186 ? -51.87847 -17.57057 22.19001  1.000 44.33833 ? 186 VAL B CA  1 
ATOM   3673 C C   . VAL B 1 186 ? -50.64912 -18.05849 22.94271  1.000 43.02424 ? 186 VAL B C   1 
ATOM   3674 O O   . VAL B 1 186 ? -49.89800 -18.90906 22.45964  1.000 43.95291 ? 186 VAL B O   1 
ATOM   3675 C CB  . VAL B 1 186 ? -53.16117 -18.25254 22.71829  1.000 44.39980 ? 186 VAL B CB  1 
ATOM   3676 C CG1 . VAL B 1 186 ? -54.38480 -17.59856 22.10975  1.000 47.27966 ? 186 VAL B CG1 1 
ATOM   3677 C CG2 . VAL B 1 186 ? -53.13430 -19.73905 22.38366  1.000 46.16626 ? 186 VAL B CG2 1 
ATOM   3678 N N   . ASP B 1 187 ? -50.42852 -17.49395 24.13541  1.000 42.98417 ? 187 ASP B N   1 
ATOM   3679 C CA  . ASP B 1 187 ? -49.28717 -17.91529 24.96251  1.000 46.99227 ? 187 ASP B CA  1 
ATOM   3680 C C   . ASP B 1 187 ? -49.70379 -19.06357 25.88377  1.000 50.47468 ? 187 ASP B C   1 
ATOM   3681 O O   . ASP B 1 187 ? -49.80616 -18.94186 27.10816  1.000 53.28905 ? 187 ASP B O   1 
ATOM   3682 C CB  . ASP B 1 187 ? -48.71306 -16.74509 25.75299  1.000 45.22054 ? 187 ASP B CB  1 
ATOM   3683 C CG  . ASP B 1 187 ? -49.78225 -15.93314 26.46225  1.000 44.82088 ? 187 ASP B CG  1 
ATOM   3684 O OD1 . ASP B 1 187 ? -50.97710 -16.14552 26.17164  1.000 48.56667 ? 187 ASP B OD1 1 
ATOM   3685 O OD2 . ASP B 1 187 ? -49.42606 -15.08346 27.31075  1.000 43.77607 ? 187 ASP B OD2 1 
ATOM   3686 N N   . ARG B 1 188 ? -49.95383 -20.19430 25.24877  1.000 46.22255 ? 188 ARG B N   1 
ATOM   3687 C CA  . ARG B 1 188 ? -50.13026 -21.47243 25.91339  1.000 56.36123 ? 188 ARG B CA  1 
ATOM   3688 C C   . ARG B 1 188 ? -49.24040 -22.47567 25.19959  1.000 59.05592 ? 188 ARG B C   1 
ATOM   3689 O O   . ARG B 1 188 ? -49.09548 -22.42164 23.97570  1.000 53.94117 ? 188 ARG B O   1 
ATOM   3690 C CB  . ARG B 1 188 ? -51.59085 -21.93060 25.88355  1.000 52.30309 ? 188 ARG B CB  1 
ATOM   3691 N N   . GLN B 1 189 ? -48.63411 -23.37636 25.96965  1.000 65.49349 ? 189 GLN B N   1 
ATOM   3692 C CA  . GLN B 1 189 ? -47.75945 -24.40966 25.42551  1.000 62.14121 ? 189 GLN B CA  1 
ATOM   3693 C C   . GLN B 1 189 ? -48.54009 -25.50684 24.70945  1.000 62.06582 ? 189 GLN B C   1 
ATOM   3694 O O   . GLN B 1 189 ? -48.62050 -26.64014 25.19703  1.000 63.86169 ? 189 GLN B O   1 
ATOM   3695 C CB  . GLN B 1 189 ? -46.92468 -25.02838 26.54252  1.000 64.67586 ? 189 GLN B CB  1 
ATOM   3696 C CG  . GLN B 1 189 ? -45.99192 -26.10998 26.06334  1.000 61.82017 ? 189 GLN B CG  1 
ATOM   3697 C CD  . GLN B 1 189 ? -44.67588 -25.54081 25.63478  1.000 61.73519 ? 189 GLN B CD  1 
ATOM   3698 O OE1 . GLN B 1 189 ? -44.21352 -24.55769 26.21300  1.000 55.38053 ? 189 GLN B OE1 1 
ATOM   3699 N NE2 . GLN B 1 189 ? -44.06028 -26.13993 24.61080  1.000 59.91051 ? 189 GLN B NE2 1 
ATOM   3700 N N   . ILE B 1 190 ? -49.10871 -25.18485 23.55095  1.000 61.61279 ? 190 ILE B N   1 
ATOM   3701 C CA  . ILE B 1 190 ? -49.88811 -26.12886 22.76149  1.000 63.10976 ? 190 ILE B CA  1 
ATOM   3702 C C   . ILE B 1 190 ? -49.54315 -25.92056 21.29080  1.000 63.89405 ? 190 ILE B C   1 
ATOM   3703 O O   . ILE B 1 190 ? -49.21583 -24.80710 20.86121  1.000 61.14196 ? 190 ILE B O   1 
ATOM   3704 C CB  . ILE B 1 190 ? -51.40550 -25.96202 23.02265  1.000 63.07003 ? 190 ILE B CB  1 
ATOM   3705 C CG1 . ILE B 1 190 ? -52.18473 -27.14247 22.43920  1.000 62.22122 ? 190 ILE B CG1 1 
ATOM   3706 C CG2 . ILE B 1 190 ? -51.90514 -24.64133 22.44679  1.000 58.42470 ? 190 ILE B CG2 1 
ATOM   3707 C CD1 . ILE B 1 190 ? -53.66757 -27.12179 22.75500  1.000 62.42656 ? 190 ILE B CD1 1 
ATOM   3708 N N   . ALA B 1 191 ? -49.58504 -27.00616 20.51743  1.000 61.86504 ? 191 ALA B N   1 
ATOM   3709 C CA  . ALA B 1 191 ? -49.24924 -26.90200 19.10079  1.000 60.85388 ? 191 ALA B CA  1 
ATOM   3710 C C   . ALA B 1 191 ? -50.23264 -25.97185 18.40121  1.000 59.25771 ? 191 ALA B C   1 
ATOM   3711 O O   . ALA B 1 191 ? -51.44734 -26.05892 18.60914  1.000 50.37121 ? 191 ALA B O   1 
ATOM   3712 C CB  . ALA B 1 191 ? -49.24966 -28.27996 18.43195  1.000 59.28620 ? 191 ALA B CB  1 
ATOM   3713 N N   . GLN B 1 192 ? -49.69627 -25.05971 17.58788  1.000 58.19839 ? 192 GLN B N   1 
ATOM   3714 C CA  . GLN B 1 192 ? -50.49432 -24.06428 16.89011  1.000 52.14840 ? 192 GLN B CA  1 
ATOM   3715 C C   . GLN B 1 192 ? -49.98074 -23.95487 15.46615  1.000 52.10896 ? 192 GLN B C   1 
ATOM   3716 O O   . GLN B 1 192 ? -48.77063 -24.02633 15.22599  1.000 56.90264 ? 192 GLN B O   1 
ATOM   3717 C CB  . GLN B 1 192 ? -50.43180 -22.69932 17.59705  1.000 52.77175 ? 192 GLN B CB  1 
ATOM   3718 C CG  . GLN B 1 192 ? -50.81358 -22.76826 19.07042  1.000 50.87619 ? 192 GLN B CG  1 
ATOM   3719 C CD  . GLN B 1 192 ? -50.77080 -21.42810 19.76060  1.000 47.72538 ? 192 GLN B CD  1 
ATOM   3720 O OE1 . GLN B 1 192 ? -51.34584 -20.44575 19.28525  1.000 50.24967 ? 192 GLN B OE1 1 
ATOM   3721 N NE2 . GLN B 1 192 ? -50.08453 -21.37652 20.89488  1.000 46.69983 ? 192 GLN B NE2 1 
ATOM   3722 N N   . ALA B 1 193 ? -50.89284 -23.79540 14.52086  1.000 46.33592 ? 193 ALA B N   1 
ATOM   3723 C CA  . ALA B 1 193 ? -50.51738 -23.77399 13.11673  1.000 48.81253 ? 193 ALA B CA  1 
ATOM   3724 C C   . ALA B 1 193 ? -50.52758 -22.34585 12.59065  1.000 47.39318 ? 193 ALA B C   1 
ATOM   3725 O O   . ALA B 1 193 ? -51.52299 -21.62982 12.73489  1.000 44.36372 ? 193 ALA B O   1 
ATOM   3726 C CB  . ALA B 1 193 ? -51.45556 -24.64169 12.28378  1.000 39.79086 ? 193 ALA B CB  1 
ATOM   3727 N N   . ALA B 1 194 ? -49.42940 -21.93664 11.97073  1.000 54.93514 ? 194 ALA B N   1 
ATOM   3728 C CA  . ALA B 1 194 ? -49.47421 -20.69669 11.21520  1.000 49.31287 ? 194 ALA B CA  1 
ATOM   3729 C C   . ALA B 1 194 ? -50.28550 -20.91058 9.94294   1.000 50.21538 ? 194 ALA B C   1 
ATOM   3730 O O   . ALA B 1 194 ? -50.31667 -22.00653 9.37707   1.000 52.57159 ? 194 ALA B O   1 
ATOM   3731 C CB  . ALA B 1 194 ? -48.06746 -20.21940 10.87372  1.000 47.81373 ? 194 ALA B CB  1 
ATOM   3732 N N   . GLY B 1 195 ? -50.98044 -19.86361 9.51908   1.000 48.25141 ? 195 GLY B N   1 
ATOM   3733 C CA  . GLY B 1 195 ? -51.54685 -19.83507 8.18579   1.000 50.33517 ? 195 GLY B CA  1 
ATOM   3734 C C   . GLY B 1 195 ? -50.51850 -20.11265 7.10631   1.000 53.99761 ? 195 GLY B C   1 
ATOM   3735 O O   . GLY B 1 195 ? -49.30861 -20.06914 7.35385   1.000 45.09005 ? 195 GLY B O   1 
ATOM   3736 N N   . THR B 1 196 ? -50.98137 -20.43847 5.90690   1.000 57.22065 ? 196 THR B N   1 
ATOM   3737 C CA  . THR B 1 196 ? -50.04652 -20.67994 4.82205   1.000 54.42450 ? 196 THR B CA  1 
ATOM   3738 C C   . THR B 1 196 ? -49.31265 -19.38134 4.51292   1.000 48.36453 ? 196 THR B C   1 
ATOM   3739 O O   . THR B 1 196 ? -49.92857 -18.32348 4.36994   1.000 52.18623 ? 196 THR B O   1 
ATOM   3740 C CB  . THR B 1 196 ? -50.77908 -21.21156 3.58113   1.000 57.52438 ? 196 THR B CB  1 
ATOM   3741 O OG1 . THR B 1 196 ? -51.04616 -22.61935 3.73299   1.000 61.20318 ? 196 THR B OG1 1 
ATOM   3742 C CG2 . THR B 1 196 ? -49.94047 -20.98165 2.31554   1.000 58.10818 ? 196 THR B CG2 1 
ATOM   3743 N N   . ASP B 1 197 ? -47.99354 -19.44798 4.45047   1.000 47.57420 ? 197 ASP B N   1 
ATOM   3744 C CA  . ASP B 1 197 ? -47.26510 -18.21771 4.18605   1.000 51.16140 ? 197 ASP B CA  1 
ATOM   3745 C C   . ASP B 1 197 ? -47.22407 -17.91239 2.68560   1.000 52.54591 ? 197 ASP B C   1 
ATOM   3746 O O   . ASP B 1 197 ? -47.50502 -18.76480 1.83540   1.000 55.24079 ? 197 ASP B O   1 
ATOM   3747 C CB  . ASP B 1 197 ? -45.84775 -18.28686 4.74509   1.000 47.26067 ? 197 ASP B CB  1 
ATOM   3748 C CG  . ASP B 1 197 ? -45.23258 -16.89145 4.93769   1.000 49.80815 ? 197 ASP B CG  1 
ATOM   3749 O OD1 . ASP B 1 197 ? -45.99316 -15.90493 5.16554   1.000 45.11116 ? 197 ASP B OD1 1 
ATOM   3750 O OD2 . ASP B 1 197 ? -43.99229 -16.78678 4.84712   1.000 47.01149 ? 197 ASP B OD2 1 
ATOM   3751 N N   . THR B 1 198 ? -46.88416 -16.66332 2.37083   1.000 50.72688 ? 198 THR B N   1 
ATOM   3752 C CA  . THR B 1 198 ? -46.77020 -16.19022 0.99907   1.000 50.44938 ? 198 THR B CA  1 
ATOM   3753 C C   . THR B 1 198 ? -45.56950 -15.25747 0.90926   1.000 41.34718 ? 198 THR B C   1 
ATOM   3754 O O   . THR B 1 198 ? -45.05245 -14.78483 1.92360   1.000 46.57905 ? 198 THR B O   1 
ATOM   3755 C CB  . THR B 1 198 ? -48.04289 -15.46842 0.53955   1.000 46.99829 ? 198 THR B CB  1 
ATOM   3756 O OG1 . THR B 1 198 ? -48.31313 -14.37207 1.42324   1.000 48.04239 ? 198 THR B OG1 1 
ATOM   3757 C CG2 . THR B 1 198 ? -49.22835 -16.42563 0.52384   1.000 49.54395 ? 198 THR B CG2 1 
ATOM   3758 N N   . THR B 1 199 ? -45.13304 -14.98633 -0.31567  1.000 43.71371 ? 199 THR B N   1 
ATOM   3759 C CA  . THR B 1 199 ? -43.96358 -14.14376 -0.56500  1.000 40.44604 ? 199 THR B CA  1 
ATOM   3760 C C   . THR B 1 199 ? -44.35923 -12.67169 -0.64273  1.000 38.97315 ? 199 THR B C   1 
ATOM   3761 O O   . THR B 1 199 ? -45.37755 -12.32156 -1.24316  1.000 38.39769 ? 199 THR B O   1 
ATOM   3762 C CB  . THR B 1 199 ? -43.26574 -14.56781 -1.86246  1.000 42.95309 ? 199 THR B CB  1 
ATOM   3763 O OG1 . THR B 1 199 ? -42.99178 -15.97171 -1.82521  1.000 43.83948 ? 199 THR B OG1 1 
ATOM   3764 C CG2 . THR B 1 199 ? -41.94671 -13.84884 -2.03128  1.000 39.36122 ? 199 THR B CG2 1 
ATOM   3765 N N   . ILE B 1 200 ? -43.55177 -11.80571 -0.02611  1.000 34.89150 ? 200 ILE B N   1 
ATOM   3766 C CA  . ILE B 1 200 ? -43.85172 -10.37508 -0.00411  1.000 33.07576 ? 200 ILE B CA  1 
ATOM   3767 C C   . ILE B 1 200 ? -43.39051 -9.73902  -1.32266  1.000 40.95320 ? 200 ILE B C   1 
ATOM   3768 O O   . ILE B 1 200 ? -42.23778 -9.31038  -1.45376  1.000 35.31691 ? 200 ILE B O   1 
ATOM   3769 C CB  . ILE B 1 200 ? -43.18924 -9.68292  1.20057   1.000 35.72549 ? 200 ILE B CB  1 
ATOM   3770 C CG1 . ILE B 1 200 ? -43.43227 -10.47818 2.48213   1.000 38.10454 ? 200 ILE B CG1 1 
ATOM   3771 C CG2 . ILE B 1 200 ? -43.70179 -8.25359  1.34369   1.000 35.68238 ? 200 ILE B CG2 1 
ATOM   3772 C CD1 . ILE B 1 200 ? -42.37603 -10.23978 3.54960   1.000 37.12397 ? 200 ILE B CD1 1 
ATOM   3773 N N   . THR B 1 201 ? -44.31011 -9.64790  -2.29194  1.000 42.63653 ? 201 THR B N   1 
ATOM   3774 C CA  . THR B 1 201 ? -43.97311 -9.26278  -3.66291  1.000 39.20928 ? 201 THR B CA  1 
ATOM   3775 C C   . THR B 1 201 ? -43.29700 -7.89791  -3.73513  1.000 38.58001 ? 201 THR B C   1 
ATOM   3776 O O   . THR B 1 201 ? -42.29128 -7.72762  -4.44002  1.000 40.36580 ? 201 THR B O   1 
ATOM   3777 C CB  . THR B 1 201 ? -45.23938 -9.27013  -4.52132  1.000 40.02776 ? 201 THR B CB  1 
ATOM   3778 O OG1 . THR B 1 201 ? -45.95162 -10.50154 -4.32083  1.000 44.91151 ? 201 THR B OG1 1 
ATOM   3779 C CG2 . THR B 1 201 ? -44.88671 -9.10784  -6.00176  1.000 41.23933 ? 201 THR B CG2 1 
ATOM   3780 N N   . VAL B 1 202 ? -43.84731 -6.89396  -3.04489  1.000 36.82004 ? 202 VAL B N   1 
ATOM   3781 C CA  . VAL B 1 202 ? -43.25300 -5.56430  -3.15986  1.000 35.62751 ? 202 VAL B CA  1 
ATOM   3782 C C   . VAL B 1 202 ? -41.80283 -5.59138  -2.69382  1.000 38.83255 ? 202 VAL B C   1 
ATOM   3783 O O   . VAL B 1 202 ? -40.95527 -4.88845  -3.25045  1.000 35.94055 ? 202 VAL B O   1 
ATOM   3784 C CB  . VAL B 1 202 ? -44.09070 -4.50664  -2.40876  1.000 36.06381 ? 202 VAL B CB  1 
ATOM   3785 C CG1 . VAL B 1 202 ? -44.13167 -4.77504  -0.88842  1.000 34.89526 ? 202 VAL B CG1 1 
ATOM   3786 C CG2 . VAL B 1 202 ? -43.57268 -3.08574  -2.73068  1.000 39.49536 ? 202 VAL B CG2 1 
ATOM   3787 N N   . ASN B 1 203 ? -41.48655 -6.43001  -1.69888  1.000 39.12899 ? 203 ASN B N   1 
ATOM   3788 C CA  . ASN B 1 203 ? -40.10691 -6.55664  -1.24258  1.000 34.96786 ? 203 ASN B CA  1 
ATOM   3789 C C   . ASN B 1 203 ? -39.22254 -7.23610  -2.27911  1.000 37.83204 ? 203 ASN B C   1 
ATOM   3790 O O   . ASN B 1 203 ? -38.04552 -6.88771  -2.41088  1.000 38.04352 ? 203 ASN B O   1 
ATOM   3791 C CB  . ASN B 1 203 ? -40.04463 -7.33233  0.06897   1.000 31.31050 ? 203 ASN B CB  1 
ATOM   3792 C CG  . ASN B 1 203 ? -40.55759 -6.52657  1.24613   1.000 36.13856 ? 203 ASN B CG  1 
ATOM   3793 O OD1 . ASN B 1 203 ? -41.07008 -5.40158  1.09425   1.000 32.78685 ? 203 ASN B OD1 1 
ATOM   3794 N ND2 . ASN B 1 203 ? -40.42381 -7.09857  2.43519   1.000 34.51904 ? 203 ASN B ND2 1 
ATOM   3795 N N   . VAL B 1 204 ? -39.74366 -8.23984  -2.98633  1.000 36.22289 ? 204 VAL B N   1 
ATOM   3796 C CA  . VAL B 1 204 ? -38.93606 -8.87051  -4.02137  1.000 32.92494 ? 204 VAL B CA  1 
ATOM   3797 C C   . VAL B 1 204 ? -38.57220 -7.84735  -5.08882  1.000 37.87306 ? 204 VAL B C   1 
ATOM   3798 O O   . VAL B 1 204 ? -37.42049 -7.77435  -5.53764  1.000 38.04046 ? 204 VAL B O   1 
ATOM   3799 C CB  . VAL B 1 204 ? -39.66942 -10.07882 -4.62599  1.000 38.44147 ? 204 VAL B CB  1 
ATOM   3800 C CG1 . VAL B 1 204 ? -38.89037 -10.59414 -5.80792  1.000 36.70389 ? 204 VAL B CG1 1 
ATOM   3801 C CG2 . VAL B 1 204 ? -39.87087 -11.17274 -3.57092  1.000 33.14707 ? 204 VAL B CG2 1 
ATOM   3802 N N   . LEU B 1 205 ? -39.54966 -7.03967  -5.50599  1.000 34.66041 ? 205 LEU B N   1 
ATOM   3803 C CA  . LEU B 1 205 ? -39.30574 -6.01492  -6.51307  1.000 41.78648 ? 205 LEU B CA  1 
ATOM   3804 C C   . LEU B 1 205 ? -38.28483 -4.99093  -6.03406  1.000 39.46110 ? 205 LEU B C   1 
ATOM   3805 O O   . LEU B 1 205 ? -37.40887 -4.57874  -6.80090  1.000 41.99913 ? 205 LEU B O   1 
ATOM   3806 C CB  . LEU B 1 205 ? -40.61754 -5.32532  -6.88643  1.000 38.54924 ? 205 LEU B CB  1 
ATOM   3807 C CG  . LEU B 1 205 ? -41.58458 -6.21611  -7.65995  1.000 41.14315 ? 205 LEU B CG  1 
ATOM   3808 C CD1 . LEU B 1 205 ? -43.03579 -5.66134  -7.68183  1.000 37.40740 ? 205 LEU B CD1 1 
ATOM   3809 C CD2 . LEU B 1 205 ? -41.05340 -6.47002  -9.05425  1.000 36.09038 ? 205 LEU B CD2 1 
ATOM   3810 N N   . ALA B 1 206 ? -38.38950 -4.55073  -4.77981  1.000 37.14995 ? 206 ALA B N   1 
ATOM   3811 C CA  . ALA B 1 206 ? -37.39511 -3.62278  -4.26240  1.000 37.72051 ? 206 ALA B CA  1 
ATOM   3812 C C   . ALA B 1 206 ? -36.00683 -4.23427  -4.35505  1.000 39.81246 ? 206 ALA B C   1 
ATOM   3813 O O   . ALA B 1 206 ? -35.05259 -3.58671  -4.80593  1.000 36.33415 ? 206 ALA B O   1 
ATOM   3814 C CB  . ALA B 1 206 ? -37.71398 -3.23784  -2.82211  1.000 35.66099 ? 206 ALA B CB  1 
ATOM   3815 N N   . TRP B 1 207 ? -35.88515 -5.49667  -3.95613  1.000 34.22093 ? 207 TRP B N   1 
ATOM   3816 C CA  . TRP B 1 207 ? -34.58983 -6.16158  -3.99298  1.000 38.85172 ? 207 TRP B CA  1 
ATOM   3817 C C   . TRP B 1 207 ? -34.07611 -6.32552  -5.42104  1.000 41.17904 ? 207 TRP B C   1 
ATOM   3818 O O   . TRP B 1 207 ? -32.86962 -6.21805  -5.65789  1.000 40.12607 ? 207 TRP B O   1 
ATOM   3819 C CB  . TRP B 1 207 ? -34.70901 -7.49862  -3.27274  1.000 35.85678 ? 207 TRP B CB  1 
ATOM   3820 C CG  . TRP B 1 207 ? -33.55248 -8.45767  -3.35386  1.000 38.95343 ? 207 TRP B CG  1 
ATOM   3821 C CD1 . TRP B 1 207 ? -32.39359 -8.43547  -2.61549  1.000 37.01190 ? 207 TRP B CD1 1 
ATOM   3822 C CD2 . TRP B 1 207 ? -33.48811 -9.63628  -4.16482  1.000 39.94750 ? 207 TRP B CD2 1 
ATOM   3823 N NE1 . TRP B 1 207 ? -31.60619 -9.51597  -2.94634  1.000 31.99181 ? 207 TRP B NE1 1 
ATOM   3824 C CE2 . TRP B 1 207 ? -32.25211 -10.26317 -3.89928  1.000 40.59812 ? 207 TRP B CE2 1 
ATOM   3825 C CE3 . TRP B 1 207 ? -34.34918 -10.21171 -5.10645  1.000 37.57189 ? 207 TRP B CE3 1 
ATOM   3826 C CZ2 . TRP B 1 207 ? -31.86931 -11.45186 -4.53193  1.000 42.26227 ? 207 TRP B CZ2 1 
ATOM   3827 C CZ3 . TRP B 1 207 ? -33.95944 -11.38231 -5.74651  1.000 40.38239 ? 207 TRP B CZ3 1 
ATOM   3828 C CH2 . TRP B 1 207 ? -32.74137 -11.99458 -5.44935  1.000 36.87113 ? 207 TRP B CH2 1 
ATOM   3829 N N   . LEU B 1 208 ? -34.96162 -6.55496  -6.39080  1.000 41.75845 ? 208 LEU B N   1 
ATOM   3830 C CA  . LEU B 1 208 ? -34.51311 -6.53283  -7.78100  1.000 40.57123 ? 208 LEU B CA  1 
ATOM   3831 C C   . LEU B 1 208 ? -33.96333 -5.16450  -8.16258  1.000 41.83558 ? 208 LEU B C   1 
ATOM   3832 O O   . LEU B 1 208 ? -32.97970 -5.06987  -8.90528  1.000 41.60882 ? 208 LEU B O   1 
ATOM   3833 C CB  . LEU B 1 208 ? -35.64980 -6.93073  -8.71173  1.000 37.62476 ? 208 LEU B CB  1 
ATOM   3834 C CG  . LEU B 1 208 ? -36.08853 -8.39266  -8.59262  1.000 36.89088 ? 208 LEU B CG  1 
ATOM   3835 C CD1 . LEU B 1 208 ? -37.21429 -8.70139  -9.56878  1.000 37.53968 ? 208 LEU B CD1 1 
ATOM   3836 C CD2 . LEU B 1 208 ? -34.91673 -9.34593  -8.80993  1.000 39.73116 ? 208 LEU B CD2 1 
ATOM   3837 N N   . TYR B 1 209 ? -34.59151 -4.08876  -7.67964  1.000 42.62804 ? 209 TYR B N   1 
ATOM   3838 C CA  . TYR B 1 209 ? -34.05355 -2.75135  -7.93070  1.000 39.75309 ? 209 TYR B CA  1 
ATOM   3839 C C   . TYR B 1 209 ? -32.70794 -2.55299  -7.24546  1.000 44.54354 ? 209 TYR B C   1 
ATOM   3840 O O   . TYR B 1 209 ? -31.78028 -1.97580  -7.83582  1.000 38.64191 ? 209 TYR B O   1 
ATOM   3841 C CB  . TYR B 1 209 ? -35.03315 -1.68322  -7.46535  1.000 38.40446 ? 209 TYR B CB  1 
ATOM   3842 C CG  . TYR B 1 209 ? -36.15149 -1.38988  -8.42877  1.000 40.69986 ? 209 TYR B CG  1 
ATOM   3843 C CD1 . TYR B 1 209 ? -35.92347 -0.62974  -9.58422  1.000 40.94496 ? 209 TYR B CD1 1 
ATOM   3844 C CD2 . TYR B 1 209 ? -37.44671 -1.83183  -8.17197  1.000 39.25798 ? 209 TYR B CD2 1 
ATOM   3845 C CE1 . TYR B 1 209 ? -36.94558 -0.35258  -10.46625 1.000 44.63260 ? 209 TYR B CE1 1 
ATOM   3846 C CE2 . TYR B 1 209 ? -38.47613 -1.56160  -9.04963  1.000 40.66184 ? 209 TYR B CE2 1 
ATOM   3847 C CZ  . TYR B 1 209 ? -38.23061 -0.82156  -10.18747 1.000 41.54603 ? 209 TYR B CZ  1 
ATOM   3848 O OH  . TYR B 1 209 ? -39.26470 -0.56932  -11.05232 1.000 42.31551 ? 209 TYR B OH  1 
ATOM   3849 N N   . ALA B 1 210 ? -32.58723 -2.99879  -5.99056  1.000 36.45301 ? 210 ALA B N   1 
ATOM   3850 C CA  . ALA B 1 210 ? -31.28415 -2.99144  -5.33351  1.000 37.31849 ? 210 ALA B CA  1 
ATOM   3851 C C   . ALA B 1 210 ? -30.23741 -3.69823  -6.19023  1.000 43.92209 ? 210 ALA B C   1 
ATOM   3852 O O   . ALA B 1 210 ? -29.08690 -3.24964  -6.27419  1.000 40.12218 ? 210 ALA B O   1 
ATOM   3853 C CB  . ALA B 1 210 ? -31.37306 -3.64211  -3.95512  1.000 42.16266 ? 210 ALA B CB  1 
ATOM   3854 N N   . ALA B 1 211 ? -30.62073 -4.80396  -6.83538  1.000 42.87691 ? 211 ALA B N   1 
ATOM   3855 C CA  . ALA B 1 211 ? -29.68075 -5.54366  -7.67185  1.000 45.17915 ? 211 ALA B CA  1 
ATOM   3856 C C   . ALA B 1 211 ? -29.24926 -4.72149  -8.88286  1.000 47.11562 ? 211 ALA B C   1 
ATOM   3857 O O   . ALA B 1 211 ? -28.05474 -4.63289  -9.18974  1.000 48.56113 ? 211 ALA B O   1 
ATOM   3858 C CB  . ALA B 1 211 ? -30.30639 -6.86227  -8.10861  1.000 40.68107 ? 211 ALA B CB  1 
ATOM   3859 N N   . VAL B 1 212 ? -30.21132 -4.11932  -9.58806  1.000 43.77536 ? 212 VAL B N   1 
ATOM   3860 C CA  . VAL B 1 212 ? -29.87845 -3.24136  -10.70587 1.000 47.33761 ? 212 VAL B CA  1 
ATOM   3861 C C   . VAL B 1 212 ? -28.97406 -2.11426  -10.24220 1.000 48.32246 ? 212 VAL B C   1 
ATOM   3862 O O   . VAL B 1 212 ? -27.93591 -1.84357  -10.85637 1.000 52.06257 ? 212 VAL B O   1 
ATOM   3863 C CB  . VAL B 1 212 ? -31.14994 -2.69604  -11.37808 1.000 44.40357 ? 212 VAL B CB  1 
ATOM   3864 C CG1 . VAL B 1 212 ? -30.77816 -1.61363  -12.40134 1.000 47.40092 ? 212 VAL B CG1 1 
ATOM   3865 C CG2 . VAL B 1 212 ? -31.92532 -3.83620  -12.02527 1.000 43.48073 ? 212 VAL B CG2 1 
ATOM   3866 N N   . ILE B 1 213 ? -29.35516 -1.42781  -9.15723  1.000 44.34481 ? 213 ILE B N   1 
ATOM   3867 C CA  . ILE B 1 213 ? -28.51285 -0.34946  -8.64193  1.000 44.96353 ? 213 ILE B CA  1 
ATOM   3868 C C   . ILE B 1 213 ? -27.09533 -0.84391  -8.39608  1.000 52.17802 ? 213 ILE B C   1 
ATOM   3869 O O   . ILE B 1 213 ? -26.13278 -0.07301  -8.50475  1.000 48.21111 ? 213 ILE B O   1 
ATOM   3870 C CB  . ILE B 1 213 ? -29.11589 0.26118   -7.36212  1.000 42.86704 ? 213 ILE B CB  1 
ATOM   3871 C CG1 . ILE B 1 213 ? -30.38310 1.04202   -7.68688  1.000 43.84569 ? 213 ILE B CG1 1 
ATOM   3872 C CG2 . ILE B 1 213 ? -28.10441 1.16561   -6.66922  1.000 41.34775 ? 213 ILE B CG2 1 
ATOM   3873 C CD1 . ILE B 1 213 ? -31.14977 1.49018   -6.44264  1.000 39.73874 ? 213 ILE B CD1 1 
ATOM   3874 N N   . ASN B 1 214 ? -26.93512 -2.13161  -8.07816  1.000 48.42725 ? 214 ASN B N   1 
ATOM   3875 C CA  . ASN B 1 214 ? -25.61608 -2.70740  -7.84181  1.000 50.85625 ? 214 ASN B CA  1 
ATOM   3876 C C   . ASN B 1 214 ? -25.00811 -3.40508  -9.06794  1.000 53.03533 ? 214 ASN B C   1 
ATOM   3877 O O   . ASN B 1 214 ? -23.97830 -4.06762  -8.92601  1.000 52.41024 ? 214 ASN B O   1 
ATOM   3878 C CB  . ASN B 1 214 ? -25.67341 -3.68164  -6.66165  1.000 46.53821 ? 214 ASN B CB  1 
ATOM   3879 C CG  . ASN B 1 214 ? -25.42146 -2.99216  -5.32175  1.000 50.28615 ? 214 ASN B CG  1 
ATOM   3880 O OD1 . ASN B 1 214 ? -24.27332 -2.82856  -4.90358  1.000 53.34961 ? 214 ASN B OD1 1 
ATOM   3881 N ND2 . ASN B 1 214 ? -26.49591 -2.57737  -4.64718  1.000 46.03743 ? 214 ASN B ND2 1 
ATOM   3882 N N   . GLY B 1 215 ? -25.61078 -3.28290  -10.25542 1.000 51.68377 ? 215 GLY B N   1 
ATOM   3883 C CA  . GLY B 1 215 ? -25.03855 -3.82804  -11.48032 1.000 54.92341 ? 215 GLY B CA  1 
ATOM   3884 C C   . GLY B 1 215 ? -25.46663 -5.22590  -11.90762 1.000 58.73414 ? 215 GLY B C   1 
ATOM   3885 O O   . GLY B 1 215 ? -24.85913 -5.78135  -12.83410 1.000 61.74821 ? 215 GLY B O   1 
ATOM   3886 N N   . ASP B 1 216 ? -26.47000 -5.82089  -11.26804 1.000 52.65903 ? 216 ASP B N   1 
ATOM   3887 C CA  . ASP B 1 216 ? -27.02180 -7.11309  -11.68922 1.000 54.56409 ? 216 ASP B CA  1 
ATOM   3888 C C   . ASP B 1 216 ? -28.15390 -6.83964  -12.66978 1.000 58.98939 ? 216 ASP B C   1 
ATOM   3889 O O   . ASP B 1 216 ? -29.25596 -6.46772  -12.25938 1.000 53.68670 ? 216 ASP B O   1 
ATOM   3890 C CB  . ASP B 1 216 ? -27.55483 -7.88908  -10.49151 1.000 56.66495 ? 216 ASP B CB  1 
ATOM   3891 C CG  . ASP B 1 216 ? -26.68046 -9.04226  -10.10104 1.000 58.78594 ? 216 ASP B CG  1 
ATOM   3892 O OD1 . ASP B 1 216 ? -26.06532 -9.63862  -11.01193 1.000 59.13084 ? 216 ASP B OD1 1 
ATOM   3893 O OD2 . ASP B 1 216 ? -26.62460 -9.34339  -8.88302  1.000 50.34695 ? 216 ASP B OD2 1 
ATOM   3894 N N   . ARG B 1 217 ? -27.91095 -7.03558  -13.96931 1.000 56.95628 ? 217 ARG B N   1 
ATOM   3895 C CA  . ARG B 1 217 ? -28.92591 -6.69664  -14.95955 1.000 51.41199 ? 217 ARG B CA  1 
ATOM   3896 C C   . ARG B 1 217 ? -29.34677 -7.85992  -15.84232 1.000 50.39529 ? 217 ARG B C   1 
ATOM   3897 O O   . ARG B 1 217 ? -30.19196 -7.67346  -16.72472 1.000 51.86563 ? 217 ARG B O   1 
ATOM   3898 C CB  . ARG B 1 217 ? -28.44572 -5.53594  -15.83520 1.000 51.07438 ? 217 ARG B CB  1 
ATOM   3899 C CG  . ARG B 1 217 ? -28.40376 -4.19207  -15.13705 1.000 55.41320 ? 217 ARG B CG  1 
ATOM   3900 C CD  . ARG B 1 217 ? -27.98254 -3.08124  -16.10427 1.000 54.70916 ? 217 ARG B CD  1 
ATOM   3901 N NE  . ARG B 1 217 ? -28.96905 -2.88337  -17.15749 1.000 52.11412 ? 217 ARG B NE  1 
ATOM   3902 C CZ  . ARG B 1 217 ? -29.81224 -1.86254  -17.20816 1.000 50.83731 ? 217 ARG B CZ  1 
ATOM   3903 N NH1 . ARG B 1 217 ? -29.76398 -0.88365  -16.31941 1.000 56.48994 ? 217 ARG B NH1 1 
ATOM   3904 N NH2 . ARG B 1 217 ? -30.74118 -1.83206  -18.16273 1.000 44.98941 ? 217 ARG B NH2 1 
ATOM   3905 N N   . TRP B 1 218 ? -28.82561 -9.06177  -15.60932 1.000 48.07536 ? 218 TRP B N   1 
ATOM   3906 C CA  . TRP B 1 218 ? -29.10855 -10.16457 -16.51576 1.000 52.86642 ? 218 TRP B CA  1 
ATOM   3907 C C   . TRP B 1 218 ? -30.58741 -10.52000 -16.58279 1.000 54.01333 ? 218 TRP B C   1 
ATOM   3908 O O   . TRP B 1 218 ? -31.01877 -11.11035 -17.57781 1.000 52.15373 ? 218 TRP B O   1 
ATOM   3909 C CB  . TRP B 1 218 ? -28.30161 -11.40069 -16.11471 1.000 52.89027 ? 218 TRP B CB  1 
ATOM   3910 C CG  . TRP B 1 218 ? -28.61894 -11.98436 -14.74722 1.000 57.09254 ? 218 TRP B CG  1 
ATOM   3911 C CD1 . TRP B 1 218 ? -27.97485 -11.71099 -13.57177 1.000 52.78172 ? 218 TRP B CD1 1 
ATOM   3912 C CD2 . TRP B 1 218 ? -29.62047 -12.96478 -14.43126 1.000 55.46658 ? 218 TRP B CD2 1 
ATOM   3913 N NE1 . TRP B 1 218 ? -28.51173 -12.45162 -12.55294 1.000 54.56210 ? 218 TRP B NE1 1 
ATOM   3914 C CE2 . TRP B 1 218 ? -29.52863 -13.22431 -13.04969 1.000 56.32943 ? 218 TRP B CE2 1 
ATOM   3915 C CE3 . TRP B 1 218 ? -30.59462 -13.63365 -15.17634 1.000 56.97153 ? 218 TRP B CE3 1 
ATOM   3916 C CZ2 . TRP B 1 218 ? -30.36995 -14.12591 -12.40296 1.000 55.08993 ? 218 TRP B CZ2 1 
ATOM   3917 C CZ3 . TRP B 1 218 ? -31.42382 -14.52892 -14.53363 1.000 57.59580 ? 218 TRP B CZ3 1 
ATOM   3918 C CH2 . TRP B 1 218 ? -31.30935 -14.76543 -13.16054 1.000 54.74706 ? 218 TRP B CH2 1 
ATOM   3919 N N   . PHE B 1 219 ? -31.37313 -10.19387 -15.55306 1.000 54.20603 ? 219 PHE B N   1 
ATOM   3920 C CA  . PHE B 1 219 ? -32.77442 -10.60692 -15.49454 1.000 51.48014 ? 219 PHE B CA  1 
ATOM   3921 C C   . PHE B 1 219 ? -33.71900 -9.58351  -16.11666 1.000 50.40210 ? 219 PHE B C   1 
ATOM   3922 O O   . PHE B 1 219 ? -34.92308 -9.85130  -16.20748 1.000 48.82264 ? 219 PHE B O   1 
ATOM   3923 C CB  . PHE B 1 219 ? -33.18841 -10.86540 -14.03199 1.000 46.94569 ? 219 PHE B CB  1 
ATOM   3924 C CG  . PHE B 1 219 ? -32.77904 -9.75920  -13.11029 1.000 46.45197 ? 219 PHE B CG  1 
ATOM   3925 C CD1 . PHE B 1 219 ? -33.53348 -8.60299  -13.02129 1.000 45.05764 ? 219 PHE B CD1 1 
ATOM   3926 C CD2 . PHE B 1 219 ? -31.60523 -9.84402  -12.38462 1.000 49.10262 ? 219 PHE B CD2 1 
ATOM   3927 C CE1 . PHE B 1 219 ? -33.13226 -7.55470  -12.20933 1.000 46.76399 ? 219 PHE B CE1 1 
ATOM   3928 C CE2 . PHE B 1 219 ? -31.19596 -8.79741  -11.55890 1.000 48.14434 ? 219 PHE B CE2 1 
ATOM   3929 C CZ  . PHE B 1 219 ? -31.95822 -7.65024  -11.47574 1.000 46.63259 ? 219 PHE B CZ  1 
ATOM   3930 N N   . LEU B 1 220 ? -33.21493 -8.41966  -16.52632 1.000 49.25634 ? 220 LEU B N   1 
ATOM   3931 C CA  . LEU B 1 220 ? -34.05378 -7.43085  -17.18877 1.000 47.21736 ? 220 LEU B CA  1 
ATOM   3932 C C   . LEU B 1 220 ? -34.47799 -7.93192  -18.57073 1.000 49.36189 ? 220 LEU B C   1 
ATOM   3933 O O   . LEU B 1 220 ? -33.85909 -8.82505  -19.15456 1.000 51.22080 ? 220 LEU B O   1 
ATOM   3934 C CB  . LEU B 1 220 ? -33.31895 -6.09369  -17.30134 1.000 45.62054 ? 220 LEU B CB  1 
ATOM   3935 C CG  . LEU B 1 220 ? -33.02263 -5.37965  -15.98246 1.000 48.17173 ? 220 LEU B CG  1 
ATOM   3936 C CD1 . LEU B 1 220 ? -32.43549 -4.00415  -16.21541 1.000 44.97877 ? 220 LEU B CD1 1 
ATOM   3937 C CD2 . LEU B 1 220 ? -34.30648 -5.27357  -15.14121 1.000 46.20772 ? 220 LEU B CD2 1 
ATOM   3938 N N   . ASN B 1 221 ? -35.56731 -7.36324  -19.08480 1.000 53.26755 ? 221 ASN B N   1 
ATOM   3939 C CA  . ASN B 1 221 ? -36.06449 -7.73008  -20.40576 1.000 54.35126 ? 221 ASN B CA  1 
ATOM   3940 C C   . ASN B 1 221 ? -36.72838 -6.50980  -21.02517 1.000 56.49519 ? 221 ASN B C   1 
ATOM   3941 O O   . ASN B 1 221 ? -36.78993 -5.43534  -20.42046 1.000 53.47305 ? 221 ASN B O   1 
ATOM   3942 C CB  . ASN B 1 221 ? -36.99483 -8.96063  -20.35424 1.000 55.85533 ? 221 ASN B CB  1 
ATOM   3943 C CG  . ASN B 1 221 ? -38.28877 -8.72931  -19.55934 1.000 59.31390 ? 221 ASN B CG  1 
ATOM   3944 O OD1 . ASN B 1 221 ? -38.87167 -7.64390  -19.57433 1.000 59.64780 ? 221 ASN B OD1 1 
ATOM   3945 N ND2 . ASN B 1 221 ? -38.75463 -9.77945  -18.88302 1.000 53.61808 ? 221 ASN B ND2 1 
ATOM   3946 N N   . ARG B 1 222 ? -37.17303 -6.66790  -22.26908 1.000 63.35155 ? 222 ARG B N   1 
ATOM   3947 C CA  . ARG B 1 222 ? -37.84001 -5.58685  -22.98148 1.000 65.18653 ? 222 ARG B CA  1 
ATOM   3948 C C   . ARG B 1 222 ? -39.35534 -5.66323  -22.86585 1.000 62.72036 ? 222 ARG B C   1 
ATOM   3949 O O   . ARG B 1 222 ? -40.03254 -4.65541  -23.10117 1.000 67.99956 ? 222 ARG B O   1 
ATOM   3950 C CB  . ARG B 1 222 ? -37.42971 -5.58908  -24.46231 1.000 62.37849 ? 222 ARG B CB  1 
ATOM   3951 N N   . PHE B 1 223 ? -39.89431 -6.82242  -22.49434 1.000 63.55169 ? 223 PHE B N   1 
ATOM   3952 C CA  . PHE B 1 223 ? -41.32576 -6.96873  -22.31032 1.000 61.88625 ? 223 PHE B CA  1 
ATOM   3953 C C   . PHE B 1 223 ? -41.83826 -6.01477  -21.23202 1.000 62.87160 ? 223 PHE B C   1 
ATOM   3954 O O   . PHE B 1 223 ? -41.08394 -5.45046  -20.43552 1.000 60.18410 ? 223 PHE B O   1 
ATOM   3955 C CB  . PHE B 1 223 ? -41.67737 -8.39760  -21.91061 1.000 66.56921 ? 223 PHE B CB  1 
ATOM   3956 C CG  . PHE B 1 223 ? -40.95810 -9.44158  -22.69866 1.000 72.39132 ? 223 PHE B CG  1 
ATOM   3957 C CD1 . PHE B 1 223 ? -41.37906 -9.77698  -23.97713 1.000 78.12601 ? 223 PHE B CD1 1 
ATOM   3958 C CD2 . PHE B 1 223 ? -39.86576 -10.10212 -22.15978 1.000 74.74923 ? 223 PHE B CD2 1 
ATOM   3959 C CE1 . PHE B 1 223 ? -40.71764 -10.74757 -24.71037 1.000 77.56192 ? 223 PHE B CE1 1 
ATOM   3960 C CE2 . PHE B 1 223 ? -39.19529 -11.07522 -22.88792 1.000 78.65484 ? 223 PHE B CE2 1 
ATOM   3961 C CZ  . PHE B 1 223 ? -39.62447 -11.39883 -24.16375 1.000 83.21897 ? 223 PHE B CZ  1 
ATOM   3962 N N   . THR B 1 224 ? -43.15662 -5.84676  -21.21837 1.000 65.09951 ? 224 THR B N   1 
ATOM   3963 C CA  . THR B 1 224 ? -43.85199 -5.17525  -20.13365 1.000 63.49223 ? 224 THR B CA  1 
ATOM   3964 C C   . THR B 1 224 ? -45.10617 -5.98749  -19.82580 1.000 55.99853 ? 224 THR B C   1 
ATOM   3965 O O   . THR B 1 224 ? -45.40633 -6.97203  -20.50174 1.000 62.82483 ? 224 THR B O   1 
ATOM   3966 C CB  . THR B 1 224 ? -44.17117 -3.71456  -20.48660 1.000 61.01165 ? 224 THR B CB  1 
ATOM   3967 O OG1 . THR B 1 224 ? -44.69415 -3.04881  -19.32952 1.000 62.54911 ? 224 THR B OG1 1 
ATOM   3968 C CG2 . THR B 1 224 ? -45.18398 -3.64079  -21.62604 1.000 59.21601 ? 224 THR B CG2 1 
ATOM   3969 N N   . THR B 1 225 ? -45.82839 -5.59304  -18.77954 1.000 57.23263 ? 225 THR B N   1 
ATOM   3970 C CA  . THR B 1 225 ? -47.00070 -6.34599  -18.34476 1.000 55.31350 ? 225 THR B CA  1 
ATOM   3971 C C   . THR B 1 225 ? -47.99746 -5.38943  -17.70681 1.000 53.42206 ? 225 THR B C   1 
ATOM   3972 O O   . THR B 1 225 ? -47.64772 -4.28296  -17.27570 1.000 54.35767 ? 225 THR B O   1 
ATOM   3973 C CB  . THR B 1 225 ? -46.63087 -7.47343  -17.35953 1.000 52.65118 ? 225 THR B CB  1 
ATOM   3974 O OG1 . THR B 1 225 ? -47.78273 -8.28349  -17.08463 1.000 55.97326 ? 225 THR B OG1 1 
ATOM   3975 C CG2 . THR B 1 225 ? -46.11444 -6.89731  -16.05396 1.000 49.77601 ? 225 THR B CG2 1 
ATOM   3976 N N   . THR B 1 226 ? -49.25488 -5.81832  -17.67860 1.000 53.15247 ? 226 THR B N   1 
ATOM   3977 C CA  . THR B 1 226 ? -50.26546 -5.11577  -16.90588 1.000 52.00586 ? 226 THR B CA  1 
ATOM   3978 C C   . THR B 1 226 ? -50.20116 -5.56799  -15.45312 1.000 46.08542 ? 226 THR B C   1 
ATOM   3979 O O   . THR B 1 226 ? -49.74752 -6.66988  -15.14022 1.000 46.57724 ? 226 THR B O   1 
ATOM   3980 C CB  . THR B 1 226 ? -51.66898 -5.36843  -17.47166 1.000 53.29005 ? 226 THR B CB  1 
ATOM   3981 O OG1 . THR B 1 226 ? -51.99261 -6.76052  -17.35699 1.000 54.61302 ? 226 THR B OG1 1 
ATOM   3982 C CG2 . THR B 1 226 ? -51.73524 -4.95450  -18.93397 1.000 54.27712 ? 226 THR B CG2 1 
ATOM   3983 N N   . LEU B 1 227 ? -50.66317 -4.69918  -14.55528 1.000 46.64158 ? 227 LEU B N   1 
ATOM   3984 C CA  . LEU B 1 227 ? -50.76143 -5.10025  -13.15636 1.000 46.91371 ? 227 LEU B CA  1 
ATOM   3985 C C   . LEU B 1 227 ? -51.63847 -6.34384  -13.00550 1.000 50.65483 ? 227 LEU B C   1 
ATOM   3986 O O   . LEU B 1 227 ? -51.30046 -7.26146  -12.24752 1.000 46.83102 ? 227 LEU B O   1 
ATOM   3987 C CB  . LEU B 1 227 ? -51.29130 -3.93541  -12.31831 1.000 47.92475 ? 227 LEU B CB  1 
ATOM   3988 C CG  . LEU B 1 227 ? -51.19074 -3.98988  -10.79010 1.000 45.64183 ? 227 LEU B CG  1 
ATOM   3989 C CD1 . LEU B 1 227 ? -49.79051 -4.35350  -10.31386 1.000 38.49398 ? 227 LEU B CD1 1 
ATOM   3990 C CD2 . LEU B 1 227 ? -51.58597 -2.63344  -10.23558 1.000 47.68436 ? 227 LEU B CD2 1 
ATOM   3991 N N   . ASN B 1 228 ? -52.75550 -6.41009  -13.73985 1.000 51.86096 ? 228 ASN B N   1 
ATOM   3992 C CA  . ASN B 1 228 ? -53.62386 -7.58673  -13.65545 1.000 53.14866 ? 228 ASN B CA  1 
ATOM   3993 C C   . ASN B 1 228 ? -52.92447 -8.82811  -14.18704 1.000 52.69654 ? 228 ASN B C   1 
ATOM   3994 O O   . ASN B 1 228 ? -52.90070 -9.87092  -13.52600 1.000 49.58596 ? 228 ASN B O   1 
ATOM   3995 C CB  . ASN B 1 228 ? -54.92447 -7.34993  -14.41869 1.000 54.19454 ? 228 ASN B CB  1 
ATOM   3996 C CG  . ASN B 1 228 ? -55.96796 -6.67953  -13.57324 1.000 62.44520 ? 228 ASN B CG  1 
ATOM   3997 O OD1 . ASN B 1 228 ? -55.95889 -6.81309  -12.34890 1.000 68.12590 ? 228 ASN B OD1 1 
ATOM   3998 N ND2 . ASN B 1 228 ? -56.87683 -5.94562  -14.21393 1.000 68.57607 ? 228 ASN B ND2 1 
ATOM   3999 N N   . ASP B 1 229 ? -52.34618 -8.73751  -15.38698 1.000 56.64863 ? 229 ASP B N   1 
ATOM   4000 C CA  . ASP B 1 229 ? -51.64574 -9.89268  -15.93712 1.000 54.36904 ? 229 ASP B CA  1 
ATOM   4001 C C   . ASP B 1 229 ? -50.47032 -10.30266 -15.05581 1.000 51.78082 ? 229 ASP B C   1 
ATOM   4002 O O   . ASP B 1 229 ? -50.12505 -11.48765 -15.00178 1.000 54.28828 ? 229 ASP B O   1 
ATOM   4003 C CB  . ASP B 1 229 ? -51.19058 -9.60415  -17.37174 1.000 60.31219 ? 229 ASP B CB  1 
ATOM   4004 C CG  . ASP B 1 229 ? -52.35903 -9.55159  -18.36278 1.000 63.45500 ? 229 ASP B CG  1 
ATOM   4005 O OD1 . ASP B 1 229 ? -53.50477 -9.86606  -17.96660 1.000 62.11159 ? 229 ASP B OD1 1 
ATOM   4006 O OD2 . ASP B 1 229 ? -52.12986 -9.19136  -19.53901 1.000 66.01759 ? 229 ASP B OD2 1 
ATOM   4007 N N   . PHE B 1 230 ? -49.86404 -9.35800  -14.32836 1.000 50.13530 ? 230 PHE B N   1 
ATOM   4008 C CA  . PHE B 1 230 ? -48.80523 -9.74730  -13.39947 1.000 50.38763 ? 230 PHE B CA  1 
ATOM   4009 C C   . PHE B 1 230 ? -49.36238 -10.49685 -12.19223 1.000 47.36639 ? 230 PHE B C   1 
ATOM   4010 O O   . PHE B 1 230 ? -48.83416 -11.54413 -11.80884 1.000 46.58851 ? 230 PHE B O   1 
ATOM   4011 C CB  . PHE B 1 230 ? -47.99481 -8.54582  -12.91605 1.000 49.17881 ? 230 PHE B CB  1 
ATOM   4012 C CG  . PHE B 1 230 ? -47.05528 -8.90689  -11.80366 1.000 43.74101 ? 230 PHE B CG  1 
ATOM   4013 C CD1 . PHE B 1 230 ? -45.82936 -9.47413  -12.08267 1.000 45.57508 ? 230 PHE B CD1 1 
ATOM   4014 C CD2 . PHE B 1 230 ? -47.43301 -8.76142  -10.48227 1.000 46.59834 ? 230 PHE B CD2 1 
ATOM   4015 C CE1 . PHE B 1 230 ? -44.98157 -9.84169  -11.07430 1.000 43.94685 ? 230 PHE B CE1 1 
ATOM   4016 C CE2 . PHE B 1 230 ? -46.59166 -9.14167  -9.46518  1.000 44.92719 ? 230 PHE B CE2 1 
ATOM   4017 C CZ  . PHE B 1 230 ? -45.36302 -9.68096  -9.76421  1.000 45.82234 ? 230 PHE B CZ  1 
ATOM   4018 N N   . ASN B 1 231 ? -50.40640 -9.95742  -11.55312 1.000 48.35864 ? 231 ASN B N   1 
ATOM   4019 C CA  . ASN B 1 231 ? -50.94355 -10.60659 -10.35818 1.000 47.99332 ? 231 ASN B CA  1 
ATOM   4020 C C   . ASN B 1 231 ? -51.46843 -12.00605 -10.65953 1.000 50.85930 ? 231 ASN B C   1 
ATOM   4021 O O   . ASN B 1 231 ? -51.48869 -12.86431 -9.76902  1.000 49.27931 ? 231 ASN B O   1 
ATOM   4022 C CB  . ASN B 1 231 ? -52.03317 -9.74192  -9.72835  1.000 41.79551 ? 231 ASN B CB  1 
ATOM   4023 C CG  . ASN B 1 231 ? -51.45786 -8.59608  -8.90451  1.000 46.21299 ? 231 ASN B CG  1 
ATOM   4024 O OD1 . ASN B 1 231 ? -50.45289 -8.76380  -8.20696  1.000 44.06497 ? 231 ASN B OD1 1 
ATOM   4025 N ND2 . ASN B 1 231 ? -52.08112 -7.42110  -8.99398  1.000 45.59232 ? 231 ASN B ND2 1 
ATOM   4026 N N   . LEU B 1 232 ? -51.88022 -12.26674 -11.90281 1.000 52.64908 ? 232 LEU B N   1 
ATOM   4027 C CA  . LEU B 1 232 ? -52.31882 -13.61360 -12.25475 1.000 53.12220 ? 232 LEU B CA  1 
ATOM   4028 C C   . LEU B 1 232 ? -51.17982 -14.61475 -12.10574 1.000 52.49562 ? 232 LEU B C   1 
ATOM   4029 O O   . LEU B 1 232 ? -51.39510 -15.74243 -11.64642 1.000 53.37775 ? 232 LEU B O   1 
ATOM   4030 C CB  . LEU B 1 232 ? -52.88668 -13.62908 -13.67664 1.000 51.20405 ? 232 LEU B CB  1 
ATOM   4031 C CG  . LEU B 1 232 ? -54.31230 -13.07810 -13.77080 1.000 53.79869 ? 232 LEU B CG  1 
ATOM   4032 C CD1 . LEU B 1 232 ? -54.76336 -12.92216 -15.20336 1.000 59.00947 ? 232 LEU B CD1 1 
ATOM   4033 C CD2 . LEU B 1 232 ? -55.26599 -13.98785 -13.00606 1.000 52.79841 ? 232 LEU B CD2 1 
ATOM   4034 N N   . VAL B 1 233 ? -49.95450 -14.21260 -12.46280 1.000 49.94843 ? 233 VAL B N   1 
ATOM   4035 C CA  . VAL B 1 233 ? -48.80143 -15.10249 -12.31659 1.000 48.31151 ? 233 VAL B CA  1 
ATOM   4036 C C   . VAL B 1 233 ? -48.40357 -15.22785 -10.85066 1.000 49.82879 ? 233 VAL B C   1 
ATOM   4037 O O   . VAL B 1 233 ? -48.21138 -16.33456 -10.33328 1.000 53.88546 ? 233 VAL B O   1 
ATOM   4038 C CB  . VAL B 1 233 ? -47.62318 -14.60395 -13.17170 1.000 52.32924 ? 233 VAL B CB  1 
ATOM   4039 C CG1 . VAL B 1 233 ? -46.45716 -15.58632 -13.08249 1.000 49.45770 ? 233 VAL B CG1 1 
ATOM   4040 C CG2 . VAL B 1 233 ? -48.06569 -14.40036 -14.60700 1.000 51.67677 ? 233 VAL B CG2 1 
ATOM   4041 N N   . ALA B 1 234 ? -48.28952 -14.09303 -10.15675 1.000 49.88074 ? 234 ALA B N   1 
ATOM   4042 C CA  . ALA B 1 234 ? -47.97587 -14.10700 -8.72922  1.000 49.19872 ? 234 ALA B CA  1 
ATOM   4043 C C   . ALA B 1 234 ? -48.91502 -15.01437 -7.93695  1.000 50.05471 ? 234 ALA B C   1 
ATOM   4044 O O   . ALA B 1 234 ? -48.47939 -15.72482 -7.02618  1.000 49.95990 ? 234 ALA B O   1 
ATOM   4045 C CB  . ALA B 1 234 ? -48.02688 -12.68155 -8.17570  1.000 49.49782 ? 234 ALA B CB  1 
ATOM   4046 N N   . MET B 1 235 ? -50.21180 -14.98628 -8.24145  1.000 51.33737 ? 235 MET B N   1 
ATOM   4047 C CA  . MET B 1 235 ? -51.12197 -15.87497 -7.53399  1.000 51.97166 ? 235 MET B CA  1 
ATOM   4048 C C   . MET B 1 235 ? -50.65522 -17.31829 -7.65712  1.000 54.60505 ? 235 MET B C   1 
ATOM   4049 O O   . MET B 1 235 ? -50.65228 -18.06291 -6.67093  1.000 53.84788 ? 235 MET B O   1 
ATOM   4050 C CB  . MET B 1 235 ? -52.54757 -15.71453 -8.06549  1.000 55.61512 ? 235 MET B CB  1 
ATOM   4051 N N   . LYS B 1 236 ? -50.21487 -17.72116 -8.85274  1.000 50.89488 ? 236 LYS B N   1 
ATOM   4052 C CA  . LYS B 1 236 ? -49.85138 -19.12023 -9.06484  1.000 56.13416 ? 236 LYS B CA  1 
ATOM   4053 C C   . LYS B 1 236 ? -48.65109 -19.52012 -8.21031  1.000 55.13413 ? 236 LYS B C   1 
ATOM   4054 O O   . LYS B 1 236 ? -48.56474 -20.66253 -7.74239  1.000 56.52841 ? 236 LYS B O   1 
ATOM   4055 C CB  . LYS B 1 236 ? -49.56408 -19.38092 -10.54830 1.000 55.51507 ? 236 LYS B CB  1 
ATOM   4056 C CG  . LYS B 1 236 ? -50.74635 -19.15220 -11.46949 1.000 52.33911 ? 236 LYS B CG  1 
ATOM   4057 N N   . TYR B 1 237 ? -47.71327 -18.59727 -7.99267  1.000 54.93196 ? 237 TYR B N   1 
ATOM   4058 C CA  . TYR B 1 237 ? -46.49806 -18.89242 -7.24204  1.000 51.04376 ? 237 TYR B CA  1 
ATOM   4059 C C   . TYR B 1 237 ? -46.60269 -18.49625 -5.77897  1.000 51.23302 ? 237 TYR B C   1 
ATOM   4060 O O   . TYR B 1 237 ? -45.57722 -18.40658 -5.09596  1.000 50.15365 ? 237 TYR B O   1 
ATOM   4061 C CB  . TYR B 1 237 ? -45.29174 -18.21395 -7.88883  1.000 49.04646 ? 237 TYR B CB  1 
ATOM   4062 C CG  . TYR B 1 237 ? -44.96828 -18.81504 -9.22200  1.000 50.10842 ? 237 TYR B CG  1 
ATOM   4063 C CD1 . TYR B 1 237 ? -44.22111 -19.97778 -9.31278  1.000 52.95356 ? 237 TYR B CD1 1 
ATOM   4064 C CD2 . TYR B 1 237 ? -45.45760 -18.25471 -10.38698 1.000 53.44045 ? 237 TYR B CD2 1 
ATOM   4065 C CE1 . TYR B 1 237 ? -43.94632 -20.55247 -10.53788 1.000 56.51275 ? 237 TYR B CE1 1 
ATOM   4066 C CE2 . TYR B 1 237 ? -45.18857 -18.81520 -11.61360 1.000 56.11989 ? 237 TYR B CE2 1 
ATOM   4067 C CZ  . TYR B 1 237 ? -44.43087 -19.96034 -11.68586 1.000 55.65324 ? 237 TYR B CZ  1 
ATOM   4068 O OH  . TYR B 1 237 ? -44.17672 -20.51317 -12.91608 1.000 54.22728 ? 237 TYR B OH  1 
ATOM   4069 N N   . ASN B 1 238 ? -47.81968 -18.24944 -5.28995  1.000 51.31667 ? 238 ASN B N   1 
ATOM   4070 C CA  . ASN B 1 238 ? -48.05616 -17.91858 -3.88340  1.000 51.54509 ? 238 ASN B CA  1 
ATOM   4071 C C   . ASN B 1 238 ? -47.38043 -16.61030 -3.46720  1.000 47.53204 ? 238 ASN B C   1 
ATOM   4072 O O   . ASN B 1 238 ? -46.78924 -16.51118 -2.38980  1.000 47.11946 ? 238 ASN B O   1 
ATOM   4073 C CB  . ASN B 1 238 ? -47.60704 -19.05286 -2.97627  1.000 48.65619 ? 238 ASN B CB  1 
ATOM   4074 C CG  . ASN B 1 238 ? -48.62420 -19.36954 -1.93398  1.000 63.14030 ? 238 ASN B CG  1 
ATOM   4075 O OD1 . ASN B 1 238 ? -49.80804 -19.55053 -2.24131  1.000 70.37917 ? 238 ASN B OD1 1 
ATOM   4076 N ND2 . ASN B 1 238 ? -48.18847 -19.41694 -0.67863  1.000 69.53013 ? 238 ASN B ND2 1 
ATOM   4077 N N   . TYR B 1 239 ? -47.47721 -15.59815 -4.32012  1.000 46.14222 ? 239 TYR B N   1 
ATOM   4078 C CA  . TYR B 1 239 ? -47.00337 -14.25251 -4.02868  1.000 39.67226 ? 239 TYR B CA  1 
ATOM   4079 C C   . TYR B 1 239 ? -48.18477 -13.37815 -3.62315  1.000 40.04010 ? 239 TYR B C   1 
ATOM   4080 O O   . TYR B 1 239 ? -49.27837 -13.51058 -4.17785  1.000 43.47383 ? 239 TYR B O   1 
ATOM   4081 C CB  . TYR B 1 239 ? -46.32083 -13.64895 -5.25876  1.000 41.23992 ? 239 TYR B CB  1 
ATOM   4082 C CG  . TYR B 1 239 ? -44.83017 -13.89557 -5.38702  1.000 42.61481 ? 239 TYR B CG  1 
ATOM   4083 C CD1 . TYR B 1 239 ? -44.29542 -15.18007 -5.35341  1.000 46.54533 ? 239 TYR B CD1 1 
ATOM   4084 C CD2 . TYR B 1 239 ? -43.95834 -12.82581 -5.57448  1.000 43.39238 ? 239 TYR B CD2 1 
ATOM   4085 C CE1 . TYR B 1 239 ? -42.90866 -15.38207 -5.49300  1.000 45.57426 ? 239 TYR B CE1 1 
ATOM   4086 C CE2 . TYR B 1 239 ? -42.59431 -13.01117 -5.71661  1.000 43.97335 ? 239 TYR B CE2 1 
ATOM   4087 C CZ  . TYR B 1 239 ? -42.07255 -14.27848 -5.67230  1.000 46.08620 ? 239 TYR B CZ  1 
ATOM   4088 O OH  . TYR B 1 239 ? -40.71090 -14.41721 -5.80459  1.000 42.79077 ? 239 TYR B OH  1 
ATOM   4089 N N   . GLU B 1 240 ? -47.95888 -12.48542 -2.66051  1.000 44.14063 ? 240 GLU B N   1 
ATOM   4090 C CA  . GLU B 1 240 ? -48.97346 -11.50692 -2.28558  1.000 40.02101 ? 240 GLU B CA  1 
ATOM   4091 C C   . GLU B 1 240 ? -49.41376 -10.71273 -3.50956  1.000 40.95326 ? 240 GLU B C   1 
ATOM   4092 O O   . GLU B 1 240 ? -48.56360 -10.29031 -4.31152  1.000 42.07518 ? 240 GLU B O   1 
ATOM   4093 C CB  . GLU B 1 240 ? -48.43502 -10.52562 -1.24181  1.000 42.17566 ? 240 GLU B CB  1 
ATOM   4094 C CG  . GLU B 1 240 ? -48.22892 -11.11259 0.11588   1.000 53.67088 ? 240 GLU B CG  1 
ATOM   4095 C CD  . GLU B 1 240 ? -49.45739 -10.97648 0.97397   1.000 58.07891 ? 240 GLU B CD  1 
ATOM   4096 O OE1 . GLU B 1 240 ? -49.73128 -9.83495  1.40371   1.000 64.51842 ? 240 GLU B OE1 1 
ATOM   4097 O OE2 . GLU B 1 240 ? -50.14865 -12.00087 1.19746   1.000 58.60916 ? 240 GLU B OE2 1 
ATOM   4098 N N   . PRO B 1 241 ? -50.70839 -10.43109 -3.65636  1.000 37.31598 ? 241 PRO B N   1 
ATOM   4099 C CA  . PRO B 1 241 ? -51.13703 -9.53644  -4.73111  1.000 38.54028 ? 241 PRO B CA  1 
ATOM   4100 C C   . PRO B 1 241 ? -50.39429 -8.20425  -4.63158  1.000 36.61602 ? 241 PRO B C   1 
ATOM   4101 O O   . PRO B 1 241 ? -50.04322 -7.73191  -3.54667  1.000 36.20739 ? 241 PRO B O   1 
ATOM   4102 C CB  . PRO B 1 241 ? -52.64337 -9.37344  -4.48838  1.000 38.63579 ? 241 PRO B CB  1 
ATOM   4103 C CG  . PRO B 1 241 ? -53.04264 -10.61299 -3.66978  1.000 39.07722 ? 241 PRO B CG  1 
ATOM   4104 C CD  . PRO B 1 241 ? -51.83365 -10.89468 -2.81414  1.000 40.91578 ? 241 PRO B CD  1 
ATOM   4105 N N   . LEU B 1 242 ? -50.13410 -7.61141  -5.77783  1.000 39.85215 ? 242 LEU B N   1 
ATOM   4106 C CA  . LEU B 1 242 ? -49.44295 -6.32914  -5.85182  1.000 34.80262 ? 242 LEU B CA  1 
ATOM   4107 C C   . LEU B 1 242 ? -50.47648 -5.25324  -6.14871  1.000 36.38853 ? 242 LEU B C   1 
ATOM   4108 O O   . LEU B 1 242 ? -51.18784 -5.34631  -7.15233  1.000 39.02874 ? 242 LEU B O   1 
ATOM   4109 C CB  . LEU B 1 242 ? -48.37405 -6.35121  -6.94094  1.000 38.08929 ? 242 LEU B CB  1 
ATOM   4110 C CG  . LEU B 1 242 ? -47.42828 -5.14950  -6.89243  1.000 34.97414 ? 242 LEU B CG  1 
ATOM   4111 C CD1 . LEU B 1 242 ? -46.42630 -5.36322  -5.77393  1.000 30.44905 ? 242 LEU B CD1 1 
ATOM   4112 C CD2 . LEU B 1 242 ? -46.71711 -4.94278  -8.21934  1.000 35.13663 ? 242 LEU B CD2 1 
ATOM   4113 N N   . THR B 1 243 ? -50.55352 -4.24048  -5.29158  1.000 34.71924 ? 243 THR B N   1 
ATOM   4114 C CA  . THR B 1 243 ? -51.52025 -3.16146  -5.44965  1.000 36.32058 ? 243 THR B CA  1 
ATOM   4115 C C   . THR B 1 243 ? -50.84459 -1.90565  -5.97531  1.000 37.70103 ? 243 THR B C   1 
ATOM   4116 O O   . THR B 1 243 ? -49.62206 -1.78491  -5.97971  1.000 38.06338 ? 243 THR B O   1 
ATOM   4117 C CB  . THR B 1 243 ? -52.19664 -2.82105  -4.12372  1.000 36.80086 ? 243 THR B CB  1 
ATOM   4118 O OG1 . THR B 1 243 ? -51.24305 -2.15754  -3.28344  1.000 35.02962 ? 243 THR B OG1 1 
ATOM   4119 C CG2 . THR B 1 243 ? -52.76839 -4.10792  -3.43499  1.000 36.19667 ? 243 THR B CG2 1 
ATOM   4120 N N   . GLN B 1 244 ? -51.67585 -0.95658  -6.41271  1.000 40.13787 ? 244 GLN B N   1 
ATOM   4121 C CA  . GLN B 1 244 ? -51.16202 0.33410   -6.85853  1.000 42.23305 ? 244 GLN B CA  1 
ATOM   4122 C C   . GLN B 1 244 ? -50.43471 1.05511   -5.73095  1.000 42.78097 ? 244 GLN B C   1 
ATOM   4123 O O   . GLN B 1 244 ? -49.50206 1.82798   -5.99059  1.000 44.02805 ? 244 GLN B O   1 
ATOM   4124 C CB  . GLN B 1 244 ? -52.30754 1.19152   -7.40973  1.000 42.38034 ? 244 GLN B CB  1 
ATOM   4125 C CG  . GLN B 1 244 ? -51.86289 2.49762   -8.04808  1.000 46.69432 ? 244 GLN B CG  1 
ATOM   4126 C CD  . GLN B 1 244 ? -50.90101 2.29067   -9.20430  1.000 48.36564 ? 244 GLN B CD  1 
ATOM   4127 O OE1 . GLN B 1 244 ? -51.09269 1.40690   -10.05269 1.000 46.49837 ? 244 GLN B OE1 1 
ATOM   4128 N NE2 . GLN B 1 244 ? -49.85594 3.11557   -9.25092  1.000 46.87900 ? 244 GLN B NE2 1 
ATOM   4129 N N   . ASP B 1 245 ? -50.83019 0.81444   -4.47438  1.000 38.69995 ? 245 ASP B N   1 
ATOM   4130 C CA  . ASP B 1 245 ? -50.10451 1.42796   -3.36856  1.000 39.57190 ? 245 ASP B CA  1 
ATOM   4131 C C   . ASP B 1 245 ? -48.67974 0.91012   -3.31296  1.000 40.72534 ? 245 ASP B C   1 
ATOM   4132 O O   . ASP B 1 245 ? -47.74774 1.67121   -3.02076  1.000 40.81939 ? 245 ASP B O   1 
ATOM   4133 C CB  . ASP B 1 245 ? -50.79442 1.16584   -2.03402  1.000 34.26051 ? 245 ASP B CB  1 
ATOM   4134 C CG  . ASP B 1 245 ? -51.99048 2.04100   -1.80171  1.000 37.34408 ? 245 ASP B CG  1 
ATOM   4135 O OD1 . ASP B 1 245 ? -52.59260 2.50166   -2.78040  1.000 40.32957 ? 245 ASP B OD1 1 
ATOM   4136 O OD2 . ASP B 1 245 ? -52.33673 2.26060   -0.62404  1.000 39.78271 ? 245 ASP B OD2 1 
ATOM   4137 N N   . HIS B 1 246 ? -48.50273 -0.39350  -3.54981  1.000 39.55499 ? 246 HIS B N   1 
ATOM   4138 C CA  . HIS B 1 246 ? -47.16454 -0.96665  -3.67540  1.000 38.69640 ? 246 HIS B CA  1 
ATOM   4139 C C   . HIS B 1 246 ? -46.42908 -0.37283  -4.87042  1.000 40.41105 ? 246 HIS B C   1 
ATOM   4140 O O   . HIS B 1 246 ? -45.24154 -0.03446  -4.78395  1.000 39.23369 ? 246 HIS B O   1 
ATOM   4141 C CB  . HIS B 1 246 ? -47.24577 -2.48611  -3.84185  1.000 38.30327 ? 246 HIS B CB  1 
ATOM   4142 C CG  . HIS B 1 246 ? -47.84008 -3.20522  -2.67229  1.000 37.68521 ? 246 HIS B CG  1 
ATOM   4143 N ND1 . HIS B 1 246 ? -48.63859 -4.32054  -2.82182  1.000 37.24675 ? 246 HIS B ND1 1 
ATOM   4144 C CD2 . HIS B 1 246 ? -47.75873 -2.97278  -1.33989  1.000 37.31044 ? 246 HIS B CD2 1 
ATOM   4145 C CE1 . HIS B 1 246 ? -49.01612 -4.75206  -1.63180  1.000 37.89250 ? 246 HIS B CE1 1 
ATOM   4146 N NE2 . HIS B 1 246 ? -48.49264 -3.95562  -0.71505  1.000 36.55690 ? 246 HIS B NE2 1 
ATOM   4147 N N   . VAL B 1 247 ? -47.10635 -0.28574  -6.01576  1.000 40.54767 ? 247 VAL B N   1 
ATOM   4148 C CA  . VAL B 1 247 ? -46.47714 0.31984   -7.18290  1.000 43.49011 ? 247 VAL B CA  1 
ATOM   4149 C C   . VAL B 1 247 ? -46.02122 1.73867   -6.85603  1.000 43.23822 ? 247 VAL B C   1 
ATOM   4150 O O   . VAL B 1 247 ? -44.90440 2.14913   -7.21004  1.000 41.25438 ? 247 VAL B O   1 
ATOM   4151 C CB  . VAL B 1 247 ? -47.43924 0.28305   -8.38325  1.000 42.40750 ? 247 VAL B CB  1 
ATOM   4152 C CG1 . VAL B 1 247 ? -46.84703 1.06079   -9.54938  1.000 42.66786 ? 247 VAL B CG1 1 
ATOM   4153 C CG2 . VAL B 1 247 ? -47.74656 -1.14742  -8.78144  1.000 41.70065 ? 247 VAL B CG2 1 
ATOM   4154 N N   . ASP B 1 248 ? -46.85651 2.49629   -6.13727  1.000 39.45628 ? 248 ASP B N   1 
ATOM   4155 C CA  . ASP B 1 248 ? -46.49100 3.86752   -5.78840  1.000 45.59125 ? 248 ASP B CA  1 
ATOM   4156 C C   . ASP B 1 248 ? -45.28437 3.90788   -4.86391  1.000 46.04018 ? 248 ASP B C   1 
ATOM   4157 O O   . ASP B 1 248 ? -44.46958 4.83587   -4.94023  1.000 43.00319 ? 248 ASP B O   1 
ATOM   4158 C CB  . ASP B 1 248 ? -47.66967 4.59049   -5.13995  1.000 42.46736 ? 248 ASP B CB  1 
ATOM   4159 C CG  . ASP B 1 248 ? -48.71790 4.97605   -6.13637  1.000 40.95841 ? 248 ASP B CG  1 
ATOM   4160 O OD1 . ASP B 1 248 ? -48.41531 4.97658   -7.34587  1.000 43.87378 ? 248 ASP B OD1 1 
ATOM   4161 O OD2 . ASP B 1 248 ? -49.83770 5.28643   -5.71720  1.000 43.75417 ? 248 ASP B OD2 1 
ATOM   4162 N N   . ILE B 1 249 ? -45.14875 2.91817   -3.98011  1.000 40.42810 ? 249 ILE B N   1 
ATOM   4163 C CA  . ILE B 1 249 ? -44.06031 2.97684   -3.00971  1.000 37.99330 ? 249 ILE B CA  1 
ATOM   4164 C C   . ILE B 1 249 ? -42.72697 2.68519   -3.68663  1.000 40.11759 ? 249 ILE B C   1 
ATOM   4165 O O   . ILE B 1 249 ? -41.67368 3.17087   -3.24437  1.000 40.52668 ? 249 ILE B O   1 
ATOM   4166 C CB  . ILE B 1 249 ? -44.32801 2.01175   -1.83909  1.000 41.58348 ? 249 ILE B CB  1 
ATOM   4167 C CG1 . ILE B 1 249 ? -43.43449 2.33740   -0.64445  1.000 43.65268 ? 249 ILE B CG1 1 
ATOM   4168 C CG2 . ILE B 1 249 ? -44.06096 0.59697   -2.26899  1.000 39.20466 ? 249 ILE B CG2 1 
ATOM   4169 C CD1 . ILE B 1 249 ? -44.03024 3.33209   0.30994   1.000 50.67269 ? 249 ILE B CD1 1 
ATOM   4170 N N   . LEU B 1 250 ? -42.74347 1.91713   -4.77300  1.000 36.14496 ? 250 LEU B N   1 
ATOM   4171 C CA  . LEU B 1 250 ? -41.53883 1.64455   -5.55084  1.000 35.98527 ? 250 LEU B CA  1 
ATOM   4172 C C   . LEU B 1 250 ? -41.15462 2.80045   -6.46829  1.000 43.90433 ? 250 LEU B C   1 
ATOM   4173 O O   . LEU B 1 250 ? -40.14981 2.69377   -7.18432  1.000 39.14599 ? 250 LEU B O   1 
ATOM   4174 C CB  . LEU B 1 250 ? -41.72306 0.38357   -6.39253  1.000 36.63500 ? 250 LEU B CB  1 
ATOM   4175 C CG  . LEU B 1 250 ? -41.90587 -0.88136  -5.54837  1.000 39.16468 ? 250 LEU B CG  1 
ATOM   4176 C CD1 . LEU B 1 250 ? -42.49767 -2.00958  -6.36636  1.000 38.32832 ? 250 LEU B CD1 1 
ATOM   4177 C CD2 . LEU B 1 250 ? -40.56045 -1.28044  -4.97042  1.000 36.45339 ? 250 LEU B CD2 1 
ATOM   4178 N N   . GLY B 1 251 ? -41.92635 3.87985   -6.46196  1.000 43.26304 ? 251 GLY B N   1 
ATOM   4179 C CA  . GLY B 1 251 ? -41.68146 5.00669   -7.32844  1.000 48.20239 ? 251 GLY B CA  1 
ATOM   4180 C C   . GLY B 1 251 ? -40.23470 5.44329   -7.31406  1.000 44.92451 ? 251 GLY B C   1 
ATOM   4181 O O   . GLY B 1 251 ? -39.53644 5.37991   -8.32951  1.000 50.00410 ? 251 GLY B O   1 
ATOM   4182 N N   . PRO B 1 252 ? -39.75603 5.89508   -6.15009  1.000 44.73208 ? 252 PRO B N   1 
ATOM   4183 C CA  . PRO B 1 252 ? -38.34705 6.31342   -6.04036  1.000 44.81248 ? 252 PRO B CA  1 
ATOM   4184 C C   . PRO B 1 252 ? -37.35022 5.34729   -6.65768  1.000 45.86217 ? 252 PRO B C   1 
ATOM   4185 O O   . PRO B 1 252 ? -36.43745 5.78806   -7.36637  1.000 44.19697 ? 252 PRO B O   1 
ATOM   4186 C CB  . PRO B 1 252 ? -38.15555 6.43026   -4.52735  1.000 46.32200 ? 252 PRO B CB  1 
ATOM   4187 C CG  . PRO B 1 252 ? -39.52076 6.84459   -4.02783  1.000 45.03682 ? 252 PRO B CG  1 
ATOM   4188 C CD  . PRO B 1 252 ? -40.50743 6.12240   -4.90098  1.000 45.19255 ? 252 PRO B CD  1 
ATOM   4189 N N   . LEU B 1 253 ? -37.48541 4.03920   -6.41357  1.000 40.71892 ? 253 LEU B N   1 
ATOM   4190 C CA  . LEU B 1 253 ? -36.51181 3.10359   -6.97118  1.000 41.90433 ? 253 LEU B CA  1 
ATOM   4191 C C   . LEU B 1 253 ? -36.64429 3.00680   -8.48830  1.000 45.58532 ? 253 LEU B C   1 
ATOM   4192 O O   . LEU B 1 253 ? -35.63759 2.89555   -9.20266  1.000 45.69642 ? 253 LEU B O   1 
ATOM   4193 C CB  . LEU B 1 253 ? -36.66521 1.72664   -6.32314  1.000 38.90818 ? 253 LEU B CB  1 
ATOM   4194 C CG  . LEU B 1 253 ? -36.22762 1.67030   -4.86544  1.000 42.12194 ? 253 LEU B CG  1 
ATOM   4195 C CD1 . LEU B 1 253 ? -36.63282 0.31610   -4.22875  1.000 34.54539 ? 253 LEU B CD1 1 
ATOM   4196 C CD2 . LEU B 1 253 ? -34.73239 1.89582   -4.76269  1.000 44.74766 ? 253 LEU B CD2 1 
ATOM   4197 N N   . SER B 1 254 ? -37.87895 3.05618   -8.99233  1.000 39.81601 ? 254 SER B N   1 
ATOM   4198 C CA  . SER B 1 254 ? -38.11491 3.09003   -10.42951 1.000 41.27897 ? 254 SER B CA  1 
ATOM   4199 C C   . SER B 1 254 ? -37.45028 4.31284   -11.05453 1.000 45.84214 ? 254 SER B C   1 
ATOM   4200 O O   . SER B 1 254 ? -36.83337 4.21684   -12.11748 1.000 41.84598 ? 254 SER B O   1 
ATOM   4201 C CB  . SER B 1 254 ? -39.62302 3.10279   -10.69778 1.000 44.95496 ? 254 SER B CB  1 
ATOM   4202 O OG  . SER B 1 254 ? -39.92511 2.94486   -12.07290 1.000 45.76720 ? 254 SER B OG  1 
ATOM   4203 N N   . ALA B 1 255 ? -37.55844 5.46697   -10.39183 1.000 44.03755 ? 255 ALA B N   1 
ATOM   4204 C CA  . ALA B 1 255 ? -36.97238 6.69594   -10.91837 1.000 48.39283 ? 255 ALA B CA  1 
ATOM   4205 C C   . ALA B 1 255 ? -35.45128 6.63615   -10.90395 1.000 50.71911 ? 255 ALA B C   1 
ATOM   4206 O O   . ALA B 1 255 ? -34.79894 7.03654   -11.87701 1.000 49.83582 ? 255 ALA B O   1 
ATOM   4207 C CB  . ALA B 1 255 ? -37.46722 7.89597   -10.11124 1.000 44.77074 ? 255 ALA B CB  1 
ATOM   4208 N N   . GLN B 1 256 ? -34.86658 6.14207   -9.80894  1.000 47.46054 ? 256 GLN B N   1 
ATOM   4209 C CA  . GLN B 1 256 ? -33.41343 6.10125   -9.70867  1.000 52.48914 ? 256 GLN B CA  1 
ATOM   4210 C C   . GLN B 1 256 ? -32.81000 5.23197   -10.80449 1.000 54.35065 ? 256 GLN B C   1 
ATOM   4211 O O   . GLN B 1 256 ? -31.78649 5.59401   -11.39853 1.000 52.33823 ? 256 GLN B O   1 
ATOM   4212 C CB  . GLN B 1 256 ? -32.99942 5.60116   -8.32477  1.000 53.31134 ? 256 GLN B CB  1 
ATOM   4213 C CG  . GLN B 1 256 ? -31.50341 5.37540   -8.15470  1.000 54.86414 ? 256 GLN B CG  1 
ATOM   4214 C CD  . GLN B 1 256 ? -31.12333 5.10796   -6.71353  1.000 56.11365 ? 256 GLN B CD  1 
ATOM   4215 O OE1 . GLN B 1 256 ? -31.95727 5.22331   -5.81789  1.000 60.76731 ? 256 GLN B OE1 1 
ATOM   4216 N NE2 . GLN B 1 256 ? -29.85812 4.76412   -6.47824  1.000 58.08708 ? 256 GLN B NE2 1 
ATOM   4217 N N   . THR B 1 257 ? -33.43636 4.09360   -11.10219 1.000 45.20587 ? 257 THR B N   1 
ATOM   4218 C CA  . THR B 1 257 ? -32.90116 3.15259   -12.08432 1.000 46.83511 ? 257 THR B CA  1 
ATOM   4219 C C   . THR B 1 257 ? -33.40861 3.38098   -13.50512 1.000 42.61561 ? 257 THR B C   1 
ATOM   4220 O O   . THR B 1 257 ? -32.87767 2.77348   -14.43913 1.000 43.09276 ? 257 THR B O   1 
ATOM   4221 C CB  . THR B 1 257 ? -33.25177 1.71322   -11.68793 1.000 47.74499 ? 257 THR B CB  1 
ATOM   4222 O OG1 . THR B 1 257 ? -34.67531 1.56618   -11.67405 1.000 46.80263 ? 257 THR B OG1 1 
ATOM   4223 C CG2 . THR B 1 257 ? -32.68672 1.36445   -10.32082 1.000 46.03003 ? 257 THR B CG2 1 
ATOM   4224 N N   . GLY B 1 258 ? -34.45205 4.18230   -13.69063 1.000 46.03153 ? 258 GLY B N   1 
ATOM   4225 C CA  . GLY B 1 258 ? -35.06322 4.30880   -14.99816 1.000 45.54881 ? 258 GLY B CA  1 
ATOM   4226 C C   . GLY B 1 258 ? -35.83573 3.10761   -15.49954 1.000 50.73257 ? 258 GLY B C   1 
ATOM   4227 O O   . GLY B 1 258 ? -36.15414 3.05853   -16.69233 1.000 48.61962 ? 258 GLY B O   1 
ATOM   4228 N N   . ILE B 1 259 ? -36.15712 2.13976   -14.63944 1.000 45.65686 ? 259 ILE B N   1 
ATOM   4229 C CA  . ILE B 1 259 ? -36.92162 0.95645   -15.02059 1.000 46.39698 ? 259 ILE B CA  1 
ATOM   4230 C C   . ILE B 1 259 ? -38.32260 1.08554   -14.43456 1.000 45.49615 ? 259 ILE B C   1 
ATOM   4231 O O   . ILE B 1 259 ? -38.47717 1.23123   -13.21576 1.000 43.89487 ? 259 ILE B O   1 
ATOM   4232 C CB  . ILE B 1 259 ? -36.24116 -0.32843  -14.53650 1.000 46.87122 ? 259 ILE B CB  1 
ATOM   4233 C CG1 . ILE B 1 259 ? -34.89296 -0.48933  -15.23562 1.000 43.43182 ? 259 ILE B CG1 1 
ATOM   4234 C CG2 . ILE B 1 259 ? -37.16439 -1.55407  -14.74417 1.000 40.24450 ? 259 ILE B CG2 1 
ATOM   4235 C CD1 . ILE B 1 259 ? -34.03655 -1.51605  -14.60081 1.000 43.96173 ? 259 ILE B CD1 1 
ATOM   4236 N N   . ALA B 1 260 ? -39.33832 1.04388   -15.29905 1.000 46.79962 ? 260 ALA B N   1 
ATOM   4237 C CA  . ALA B 1 260 ? -40.71890 1.18453   -14.84821 1.000 48.44440 ? 260 ALA B CA  1 
ATOM   4238 C C   . ALA B 1 260 ? -41.11639 0.00287   -13.96852 1.000 41.16339 ? 260 ALA B C   1 
ATOM   4239 O O   . ALA B 1 260 ? -40.69084 -1.13270  -14.18933 1.000 46.87117 ? 260 ALA B O   1 
ATOM   4240 C CB  . ALA B 1 260 ? -41.67643 1.28536   -16.04334 1.000 45.81468 ? 260 ALA B CB  1 
ATOM   4241 N N   . VAL B 1 261 ? -41.96761 0.27568   -12.97512 1.000 46.80110 ? 261 VAL B N   1 
ATOM   4242 C CA  . VAL B 1 261 ? -42.34096 -0.76235  -12.01075 1.000 42.98246 ? 261 VAL B CA  1 
ATOM   4243 C C   . VAL B 1 261 ? -42.92560 -1.97427  -12.72743 1.000 43.66195 ? 261 VAL B C   1 
ATOM   4244 O O   . VAL B 1 261 ? -42.59236 -3.12651  -12.42236 1.000 46.56360 ? 261 VAL B O   1 
ATOM   4245 C CB  . VAL B 1 261 ? -43.30490 -0.19040  -10.95497 1.000 42.06578 ? 261 VAL B CB  1 
ATOM   4246 C CG1 . VAL B 1 261 ? -43.91770 -1.31394  -10.10856 1.000 42.64671 ? 261 VAL B CG1 1 
ATOM   4247 C CG2 . VAL B 1 261 ? -42.55468 0.80371   -10.07087 1.000 42.15029 ? 261 VAL B CG2 1 
ATOM   4248 N N   . LEU B 1 262 ? -43.79677 -1.73760  -13.70404 1.000 42.43055 ? 262 LEU B N   1 
ATOM   4249 C CA  . LEU B 1 262 ? -44.39265 -2.85846  -14.42346 1.000 42.52782 ? 262 LEU B CA  1 
ATOM   4250 C C   . LEU B 1 262 ? -43.38264 -3.54880  -15.34390 1.000 47.85350 ? 262 LEU B C   1 
ATOM   4251 O O   . LEU B 1 262 ? -43.51884 -4.74924  -15.62622 1.000 48.15918 ? 262 LEU B O   1 
ATOM   4252 C CB  . LEU B 1 262 ? -45.62249 -2.36677  -15.19092 1.000 42.43824 ? 262 LEU B CB  1 
ATOM   4253 C CG  . LEU B 1 262 ? -46.78454 -2.04585  -14.24176 1.000 45.51040 ? 262 LEU B CG  1 
ATOM   4254 C CD1 . LEU B 1 262 ? -47.78982 -1.12125  -14.88951 1.000 47.69413 ? 262 LEU B CD1 1 
ATOM   4255 C CD2 . LEU B 1 262 ? -47.44917 -3.34550  -13.80232 1.000 40.43727 ? 262 LEU B CD2 1 
ATOM   4256 N N   . ASP B 1 263 ? -42.35320 -2.82726  -15.80340 1.000 43.14660 ? 263 ASP B N   1 
ATOM   4257 C CA  . ASP B 1 263 ? -41.27771 -3.50133  -16.52258 1.000 46.78140 ? 263 ASP B CA  1 
ATOM   4258 C C   . ASP B 1 263 ? -40.53629 -4.45588  -15.59702 1.000 42.21726 ? 263 ASP B C   1 
ATOM   4259 O O   . ASP B 1 263 ? -40.30190 -5.62173  -15.94282 1.000 46.26115 ? 263 ASP B O   1 
ATOM   4260 C CB  . ASP B 1 263 ? -40.31791 -2.47472  -17.14578 1.000 49.09169 ? 263 ASP B CB  1 
ATOM   4261 C CG  . ASP B 1 263 ? -40.91081 -1.77183  -18.37806 1.000 55.16568 ? 263 ASP B CG  1 
ATOM   4262 O OD1 . ASP B 1 263 ? -42.04330 -2.12147  -18.78847 1.000 54.33490 ? 263 ASP B OD1 1 
ATOM   4263 O OD2 . ASP B 1 263 ? -40.24217 -0.86835  -18.94027 1.000 51.14307 ? 263 ASP B OD2 1 
ATOM   4264 N N   . MET B 1 264 ? -40.17498 -3.98462  -14.40122 1.000 43.58723 ? 264 MET B N   1 
ATOM   4265 C CA  . MET B 1 264 ? -39.61828 -4.88296  -13.39092 1.000 43.42251 ? 264 MET B CA  1 
ATOM   4266 C C   . MET B 1 264 ? -40.56956 -6.03687  -13.07546 1.000 44.98450 ? 264 MET B C   1 
ATOM   4267 O O   . MET B 1 264 ? -40.12822 -7.17585  -12.84875 1.000 43.38668 ? 264 MET B O   1 
ATOM   4268 C CB  . MET B 1 264 ? -39.28999 -4.10227  -12.12006 1.000 40.60965 ? 264 MET B CB  1 
ATOM   4269 C CG  . MET B 1 264 ? -38.38714 -4.86446  -11.17760 1.000 40.68101 ? 264 MET B CG  1 
ATOM   4270 S SD  . MET B 1 264 ? -36.76639 -5.16375  -11.93124 1.000 44.41369 ? 264 MET B SD  1 
ATOM   4271 C CE  . MET B 1 264 ? -35.91161 -3.69186  -11.42600 1.000 35.73595 ? 264 MET B CE  1 
ATOM   4272 N N   . CYS B 1 265 ? -41.88034 -5.77198  -13.05369 1.000 44.21543 ? 265 CYS B N   1 
ATOM   4273 C CA  . CYS B 1 265 ? -42.82540 -6.87145  -12.86520 1.000 43.19818 ? 265 CYS B CA  1 
ATOM   4274 C C   . CYS B 1 265 ? -42.69967 -7.89811  -13.98072 1.000 44.60420 ? 265 CYS B C   1 
ATOM   4275 O O   . CYS B 1 265 ? -42.82954 -9.10497  -13.74025 1.000 43.12230 ? 265 CYS B O   1 
ATOM   4276 C CB  . CYS B 1 265 ? -44.26094 -6.34796  -12.78900 1.000 43.86902 ? 265 CYS B CB  1 
ATOM   4277 S SG  . CYS B 1 265 ? -44.67933 -5.52727  -11.25442 1.000 42.70995 ? 265 CYS B SG  1 
ATOM   4278 N N   . ALA B 1 266 ? -42.47462 -7.44128  -15.21852 1.000 45.26294 ? 266 ALA B N   1 
ATOM   4279 C CA  . ALA B 1 266 ? -42.24896 -8.39584  -16.30365 1.000 46.80866 ? 266 ALA B CA  1 
ATOM   4280 C C   . ALA B 1 266 ? -40.99317 -9.21951  -16.04834 1.000 46.49083 ? 266 ALA B C   1 
ATOM   4281 O O   . ALA B 1 266 ? -40.98105 -10.43462 -16.27944 1.000 51.20699 ? 266 ALA B O   1 
ATOM   4282 C CB  . ALA B 1 266 ? -42.15813 -7.67755  -17.65058 1.000 47.22213 ? 266 ALA B CB  1 
ATOM   4283 N N   . SER B 1 267 ? -39.93203 -8.58254  -15.55126 1.000 46.55676 ? 267 SER B N   1 
ATOM   4284 C CA  . SER B 1 267 ? -38.74793 -9.33725  -15.15588 1.000 44.71769 ? 267 SER B CA  1 
ATOM   4285 C C   . SER B 1 267 ? -39.09562 -10.39918 -14.11990 1.000 47.94672 ? 267 SER B C   1 
ATOM   4286 O O   . SER B 1 267 ? -38.80707 -11.59026 -14.30567 1.000 49.15288 ? 267 SER B O   1 
ATOM   4287 C CB  . SER B 1 267 ? -37.68402 -8.38242  -14.62332 1.000 45.39690 ? 267 SER B CB  1 
ATOM   4288 O OG  . SER B 1 267 ? -36.58135 -8.33445  -15.49364 1.000 48.62233 ? 267 SER B OG  1 
ATOM   4289 N N   . LEU B 1 268 ? -39.73681 -9.98644  -13.02122 1.000 49.37762 ? 268 LEU B N   1 
ATOM   4290 C CA  . LEU B 1 268 ? -40.10838 -10.94280 -11.98601 1.000 44.59146 ? 268 LEU B CA  1 
ATOM   4291 C C   . LEU B 1 268 ? -40.95816 -12.06953 -12.55451 1.000 46.50660 ? 268 LEU B C   1 
ATOM   4292 O O   . LEU B 1 268 ? -40.75068 -13.24074 -12.22038 1.000 50.69443 ? 268 LEU B O   1 
ATOM   4293 C CB  . LEU B 1 268 ? -40.84090 -10.23034 -10.84582 1.000 41.61109 ? 268 LEU B CB  1 
ATOM   4294 C CG  . LEU B 1 268 ? -41.30692 -11.07553 -9.65500  1.000 42.35899 ? 268 LEU B CG  1 
ATOM   4295 C CD1 . LEU B 1 268 ? -40.19155 -11.97120 -9.08916  1.000 37.52611 ? 268 LEU B CD1 1 
ATOM   4296 C CD2 . LEU B 1 268 ? -41.86606 -10.17414 -8.56196  1.000 39.48520 ? 268 LEU B CD2 1 
ATOM   4297 N N   . LYS B 1 269 ? -41.93298 -11.74348 -13.40296 1.000 48.59958 ? 269 LYS B N   1 
ATOM   4298 C CA  . LYS B 1 269 ? -42.75025 -12.79660 -14.00309 1.000 46.78003 ? 269 LYS B CA  1 
ATOM   4299 C C   . LYS B 1 269 ? -41.87990 -13.82100 -14.72139 1.000 48.55497 ? 269 LYS B C   1 
ATOM   4300 O O   . LYS B 1 269 ? -42.03935 -15.02834 -14.52589 1.000 52.30605 ? 269 LYS B O   1 
ATOM   4301 C CB  . LYS B 1 269 ? -43.77138 -12.18726 -14.96590 1.000 52.05047 ? 269 LYS B CB  1 
ATOM   4302 C CG  . LYS B 1 269 ? -44.67275 -13.20498 -15.64484 1.000 53.04152 ? 269 LYS B CG  1 
ATOM   4303 C CD  . LYS B 1 269 ? -45.53021 -12.55445 -16.73064 1.000 54.89170 ? 269 LYS B CD  1 
ATOM   4304 C CE  . LYS B 1 269 ? -46.51300 -11.54900 -16.14005 1.000 55.98914 ? 269 LYS B CE  1 
ATOM   4305 N NZ  . LYS B 1 269 ? -47.28689 -10.79478 -17.16922 1.000 61.07063 ? 269 LYS B NZ  1 
ATOM   4306 N N   . GLU B 1 270 ? -40.93706 -13.35173 -15.55337 1.000 52.04407 ? 270 GLU B N   1 
ATOM   4307 C CA  . GLU B 1 270 ? -40.03410 -14.26957 -16.24650 1.000 53.42893 ? 270 GLU B CA  1 
ATOM   4308 C C   . GLU B 1 270 ? -39.24344 -15.11529 -15.24967 1.000 55.41744 ? 270 GLU B C   1 
ATOM   4309 O O   . GLU B 1 270 ? -39.21723 -16.34899 -15.34841 1.000 58.38085 ? 270 GLU B O   1 
ATOM   4310 C CB  . GLU B 1 270 ? -39.09698 -13.48668 -17.17646 1.000 47.38619 ? 270 GLU B CB  1 
ATOM   4311 N N   . LEU B 1 271 ? -38.60614 -14.46572 -14.26573 1.000 52.44867 ? 271 LEU B N   1 
ATOM   4312 C CA  . LEU B 1 271 ? -37.86128 -15.19482 -13.23861 1.000 49.89729 ? 271 LEU B CA  1 
ATOM   4313 C C   . LEU B 1 271 ? -38.70874 -16.27041 -12.56883 1.000 54.33080 ? 271 LEU B C   1 
ATOM   4314 O O   . LEU B 1 271 ? -38.19305 -17.32683 -12.18645 1.000 54.48700 ? 271 LEU B O   1 
ATOM   4315 C CB  . LEU B 1 271 ? -37.32768 -14.22271 -12.18225 1.000 49.86803 ? 271 LEU B CB  1 
ATOM   4316 C CG  . LEU B 1 271 ? -36.11173 -13.36576 -12.53144 1.000 49.48202 ? 271 LEU B CG  1 
ATOM   4317 C CD1 . LEU B 1 271 ? -35.88075 -12.28131 -11.48546 1.000 46.57117 ? 271 LEU B CD1 1 
ATOM   4318 C CD2 . LEU B 1 271 ? -34.88947 -14.24849 -12.64424 1.000 55.37792 ? 271 LEU B CD2 1 
ATOM   4319 N N   . LEU B 1 272 ? -40.00647 -16.01257 -12.38458 1.000 50.78272 ? 272 LEU B N   1 
ATOM   4320 C CA  . LEU B 1 272 ? -40.84091 -16.98098 -11.67674 1.000 54.90189 ? 272 LEU B CA  1 
ATOM   4321 C C   . LEU B 1 272 ? -41.15791 -18.18339 -12.55232 1.000 54.14994 ? 272 LEU B C   1 
ATOM   4322 O O   . LEU B 1 272 ? -41.17114 -19.32454 -12.07533 1.000 53.00906 ? 272 LEU B O   1 
ATOM   4323 C CB  . LEU B 1 272 ? -42.13713 -16.32329 -11.20385 1.000 52.59011 ? 272 LEU B CB  1 
ATOM   4324 C CG  . LEU B 1 272 ? -42.12145 -15.57749 -9.87084  1.000 50.54561 ? 272 LEU B CG  1 
ATOM   4325 C CD1 . LEU B 1 272 ? -43.42460 -14.80024 -9.71862  1.000 44.25710 ? 272 LEU B CD1 1 
ATOM   4326 C CD2 . LEU B 1 272 ? -41.92550 -16.55611 -8.72852  1.000 51.43836 ? 272 LEU B CD2 1 
ATOM   4327 N N   . GLN B 1 273 ? -41.42128 -17.94428 -13.83688 1.000 59.31547 ? 273 GLN B N   1 
ATOM   4328 C CA  . GLN B 1 273 ? -41.81492 -19.03018 -14.72571 1.000 61.08138 ? 273 GLN B CA  1 
ATOM   4329 C C   . GLN B 1 273 ? -40.63153 -19.90855 -15.11116 1.000 63.01268 ? 273 GLN B C   1 
ATOM   4330 O O   . GLN B 1 273 ? -40.81185 -21.10583 -15.37270 1.000 62.32560 ? 273 GLN B O   1 
ATOM   4331 C CB  . GLN B 1 273 ? -42.48976 -18.45619 -15.97253 1.000 58.82586 ? 273 GLN B CB  1 
ATOM   4332 C CG  . GLN B 1 273 ? -43.85529 -17.84032 -15.69841 1.000 58.10814 ? 273 GLN B CG  1 
ATOM   4333 C CD  . GLN B 1 273 ? -44.35979 -17.00981 -16.85724 1.000 57.04988 ? 273 GLN B CD  1 
ATOM   4334 O OE1 . GLN B 1 273 ? -43.58161 -16.57609 -17.70628 1.000 62.78409 ? 273 GLN B OE1 1 
ATOM   4335 N NE2 . GLN B 1 273 ? -45.66726 -16.78333 -16.90186 1.000 57.27659 ? 273 GLN B NE2 1 
ATOM   4336 N N   . ASN B 1 274 ? -39.41835 -19.34633 -15.12810 1.000 62.38632 ? 274 ASN B N   1 
ATOM   4337 C CA  . ASN B 1 274 ? -38.25149 -20.04293 -15.64788 1.000 56.64142 ? 274 ASN B CA  1 
ATOM   4338 C C   . ASN B 1 274 ? -37.12847 -20.24774 -14.63862 1.000 58.05884 ? 274 ASN B C   1 
ATOM   4339 O O   . ASN B 1 274 ? -36.11308 -20.86609 -14.98166 1.000 62.55590 ? 274 ASN B O   1 
ATOM   4340 C CB  . ASN B 1 274 ? -37.72245 -19.29293 -16.87072 1.000 62.51889 ? 274 ASN B CB  1 
ATOM   4341 C CG  . ASN B 1 274 ? -38.73348 -19.26437 -17.99717 1.000 71.09557 ? 274 ASN B CG  1 
ATOM   4342 O OD1 . ASN B 1 274 ? -38.74136 -20.14297 -18.86114 1.000 79.06235 ? 274 ASN B OD1 1 
ATOM   4343 N ND2 . ASN B 1 274 ? -39.61494 -18.27117 -17.97768 1.000 71.97385 ? 274 ASN B ND2 1 
ATOM   4344 N N   . GLY B 1 275 ? -37.27862 -19.78051 -13.40979 1.000 57.36177 ? 275 GLY B N   1 
ATOM   4345 C CA  . GLY B 1 275 ? -36.18549 -19.87540 -12.46430 1.000 57.51115 ? 275 GLY B CA  1 
ATOM   4346 C C   . GLY B 1 275 ? -35.02161 -19.02182 -12.93801 1.000 60.32724 ? 275 GLY B C   1 
ATOM   4347 O O   . GLY B 1 275 ? -35.12705 -18.23921 -13.87969 1.000 58.84720 ? 275 GLY B O   1 
ATOM   4348 N N   . MET B 1 276 ? -33.88955 -19.18269 -12.25840 1.000 59.76763 ? 276 MET B N   1 
ATOM   4349 C CA  . MET B 1 276 ? -32.71564 -18.38524 -12.57892 1.000 62.74995 ? 276 MET B CA  1 
ATOM   4350 C C   . MET B 1 276 ? -31.71822 -19.11009 -13.47229 1.000 66.59650 ? 276 MET B C   1 
ATOM   4351 O O   . MET B 1 276 ? -30.82536 -18.45946 -14.02773 1.000 68.03317 ? 276 MET B O   1 
ATOM   4352 C CB  . MET B 1 276 ? -32.03350 -17.91865 -11.28863 1.000 63.67976 ? 276 MET B CB  1 
ATOM   4353 C CG  . MET B 1 276 ? -32.90691 -16.94928 -10.51498 1.000 64.47814 ? 276 MET B CG  1 
ATOM   4354 S SD  . MET B 1 276 ? -32.41309 -16.67185 -8.81367  1.000 68.27935 ? 276 MET B SD  1 
ATOM   4355 C CE  . MET B 1 276 ? -30.84289 -15.86664 -9.05518  1.000 55.04109 ? 276 MET B CE  1 
ATOM   4356 N N   . ASN B 1 277 ? -31.86790 -20.41950 -13.65578 1.000 71.06427 ? 277 ASN B N   1 
ATOM   4357 C CA  . ASN B 1 277 ? -30.99785 -21.19907 -14.53337 1.000 71.72557 ? 277 ASN B CA  1 
ATOM   4358 C C   . ASN B 1 277 ? -29.53209 -21.01510 -14.13716 1.000 72.50473 ? 277 ASN B C   1 
ATOM   4359 O O   . ASN B 1 277 ? -28.68506 -20.59259 -14.92849 1.000 76.05498 ? 277 ASN B O   1 
ATOM   4360 C CB  . ASN B 1 277 ? -31.22943 -20.83220 -16.00403 1.000 70.60030 ? 277 ASN B CB  1 
ATOM   4361 N N   . GLY B 1 278 ? -29.25322 -21.32201 -12.87018 1.000 71.05892 ? 278 GLY B N   1 
ATOM   4362 C CA  . GLY B 1 278 ? -27.89913 -21.35746 -12.36283 1.000 67.76076 ? 278 GLY B CA  1 
ATOM   4363 C C   . GLY B 1 278 ? -27.24182 -20.01854 -12.10069 1.000 68.86845 ? 278 GLY B C   1 
ATOM   4364 O O   . GLY B 1 278 ? -26.06571 -19.99385 -11.71972 1.000 68.28978 ? 278 GLY B O   1 
ATOM   4365 N N   . ARG B 1 279 ? -27.93778 -18.90684 -12.28920 1.000 68.17348 ? 279 ARG B N   1 
ATOM   4366 C CA  . ARG B 1 279 ? -27.37868 -17.60813 -11.94313 1.000 62.97141 ? 279 ARG B CA  1 
ATOM   4367 C C   . ARG B 1 279 ? -27.91131 -17.15717 -10.58703 1.000 54.97294 ? 279 ARG B C   1 
ATOM   4368 O O   . ARG B 1 279 ? -28.79433 -17.77680 -9.99664  1.000 57.02814 ? 279 ARG B O   1 
ATOM   4369 C CB  . ARG B 1 279 ? -27.68724 -16.57359 -13.02736 1.000 60.16469 ? 279 ARG B CB  1 
ATOM   4370 C CG  . ARG B 1 279 ? -26.84487 -16.74315 -14.27944 1.000 68.17538 ? 279 ARG B CG  1 
ATOM   4371 C CD  . ARG B 1 279 ? -27.46160 -16.01602 -15.45991 1.000 66.40576 ? 279 ARG B CD  1 
ATOM   4372 N NE  . ARG B 1 279 ? -28.77488 -16.56603 -15.77480 1.000 69.33799 ? 279 ARG B NE  1 
ATOM   4373 C CZ  . ARG B 1 279 ? -29.51008 -16.20515 -16.81781 1.000 68.71605 ? 279 ARG B CZ  1 
ATOM   4374 N NH1 . ARG B 1 279 ? -29.09577 -15.27654 -17.66807 1.000 63.84601 ? 279 ARG B NH1 1 
ATOM   4375 N NH2 . ARG B 1 279 ? -30.68971 -16.79194 -17.01290 1.000 69.15266 ? 279 ARG B NH2 1 
ATOM   4376 N N   . THR B 1 280 ? -27.34087 -16.07055 -10.08644 1.000 54.89973 ? 280 THR B N   1 
ATOM   4377 C CA  . THR B 1 280 ? -27.66881 -15.55573 -8.77032  1.000 52.54854 ? 280 THR B CA  1 
ATOM   4378 C C   . THR B 1 280 ? -27.98108 -14.07494 -8.87763  1.000 51.03649 ? 280 THR B C   1 
ATOM   4379 O O   . THR B 1 280 ? -27.63214 -13.41650 -9.86219  1.000 45.19448 ? 280 THR B O   1 
ATOM   4380 C CB  . THR B 1 280 ? -26.51913 -15.75788 -7.77972  1.000 49.57191 ? 280 THR B CB  1 
ATOM   4381 O OG1 . THR B 1 280 ? -25.36396 -15.05072 -8.24919  1.000 45.63007 ? 280 THR B OG1 1 
ATOM   4382 C CG2 . THR B 1 280 ? -26.19202 -17.23557 -7.63760  1.000 49.87823 ? 280 THR B CG2 1 
ATOM   4383 N N   . ILE B 1 281 ? -28.65386 -13.56174 -7.84871  1.000 47.80424 ? 281 ILE B N   1 
ATOM   4384 C CA  . ILE B 1 281 ? -28.91997 -12.13511 -7.71436  1.000 47.40368 ? 281 ILE B CA  1 
ATOM   4385 C C   . ILE B 1 281 ? -28.45582 -11.70015 -6.33133  1.000 46.75029 ? 281 ILE B C   1 
ATOM   4386 O O   . ILE B 1 281 ? -28.93057 -12.23198 -5.31604  1.000 44.17942 ? 281 ILE B O   1 
ATOM   4387 C CB  . ILE B 1 281 ? -30.40514 -11.79859 -7.93674  1.000 43.48447 ? 281 ILE B CB  1 
ATOM   4388 C CG1 . ILE B 1 281 ? -30.82105 -12.18819 -9.35336  1.000 45.39448 ? 281 ILE B CG1 1 
ATOM   4389 C CG2 . ILE B 1 281 ? -30.66607 -10.32356 -7.69323  1.000 43.48980 ? 281 ILE B CG2 1 
ATOM   4390 C CD1 . ILE B 1 281 ? -32.19803 -11.69489 -9.74943  1.000 48.81670 ? 281 ILE B CD1 1 
ATOM   4391 N N   . LEU B 1 282 ? -27.52891 -10.73771 -6.29546  1.000 49.43886 ? 282 LEU B N   1 
ATOM   4392 C CA  . LEU B 1 282 ? -26.91042 -10.26952 -5.05052  1.000 46.74969 ? 282 LEU B CA  1 
ATOM   4393 C C   . LEU B 1 282 ? -26.57916 -11.43884 -4.12233  1.000 49.35549 ? 282 LEU B C   1 
ATOM   4394 O O   . LEU B 1 282 ? -26.86103 -11.42158 -2.92053  1.000 47.73408 ? 282 LEU B O   1 
ATOM   4395 C CB  . LEU B 1 282 ? -27.80723 -9.26102  -4.33839  1.000 45.13805 ? 282 LEU B CB  1 
ATOM   4396 C CG  . LEU B 1 282 ? -28.02850 -7.92044  -5.04385  1.000 44.60426 ? 282 LEU B CG  1 
ATOM   4397 C CD1 . LEU B 1 282 ? -29.19990 -7.16571  -4.40924  1.000 42.27333 ? 282 LEU B CD1 1 
ATOM   4398 C CD2 . LEU B 1 282 ? -26.76735 -7.07356  -5.07386  1.000 44.63387 ? 282 LEU B CD2 1 
ATOM   4399 N N   . GLY B 1 283 ? -26.00091 -12.48413 -4.70642  1.000 47.30883 ? 283 GLY B N   1 
ATOM   4400 C CA  . GLY B 1 283 ? -25.49115 -13.60945 -3.95353  1.000 43.12856 ? 283 GLY B CA  1 
ATOM   4401 C C   . GLY B 1 283 ? -26.52179 -14.61568 -3.48131  1.000 50.48667 ? 283 GLY B C   1 
ATOM   4402 O O   . GLY B 1 283 ? -26.16303 -15.53549 -2.73031  1.000 52.96522 ? 283 GLY B O   1 
ATOM   4403 N N   . SER B 1 284 ? -27.78544 -14.48132 -3.87485  1.000 44.26479 ? 284 SER B N   1 
ATOM   4404 C CA  . SER B 1 284 ? -28.78738 -15.48650 -3.55415  1.000 44.54318 ? 284 SER B CA  1 
ATOM   4405 C C   . SER B 1 284 ? -29.25438 -16.19727 -4.81398  1.000 44.84804 ? 284 SER B C   1 
ATOM   4406 O O   . SER B 1 284 ? -29.47531 -15.56705 -5.84811  1.000 48.39710 ? 284 SER B O   1 
ATOM   4407 C CB  . SER B 1 284 ? -30.00648 -14.88049 -2.84205  1.000 41.03888 ? 284 SER B CB  1 
ATOM   4408 O OG  . SER B 1 284 ? -31.00837 -15.88528 -2.66280  1.000 46.93835 ? 284 SER B OG  1 
ATOM   4409 N N   . ALA B 1 285 ? -29.42659 -17.51262 -4.71060  1.000 43.45727 ? 285 ALA B N   1 
ATOM   4410 C CA  . ALA B 1 285 ? -30.11262 -18.26613 -5.74416  1.000 46.96686 ? 285 ALA B CA  1 
ATOM   4411 C C   . ALA B 1 285 ? -31.62607 -18.26921 -5.55556  1.000 48.49793 ? 285 ALA B C   1 
ATOM   4412 O O   . ALA B 1 285 ? -32.31750 -18.95116 -6.31724  1.000 51.01217 ? 285 ALA B O   1 
ATOM   4413 C CB  . ALA B 1 285 ? -29.59303 -19.70820 -5.78386  1.000 45.72871 ? 285 ALA B CB  1 
ATOM   4414 N N   . LEU B 1 286 ? -32.14842 -17.54051 -4.56390  1.000 41.52646 ? 286 LEU B N   1 
ATOM   4415 C CA  . LEU B 1 286 ? -33.57941 -17.41404 -4.32674  1.000 46.23514 ? 286 LEU B CA  1 
ATOM   4416 C C   . LEU B 1 286 ? -33.99166 -15.96091 -4.47975  1.000 43.36174 ? 286 LEU B C   1 
ATOM   4417 O O   . LEU B 1 286 ? -33.16182 -15.05562 -4.42299  1.000 42.63978 ? 286 LEU B O   1 
ATOM   4418 C CB  . LEU B 1 286 ? -33.96711 -17.89548 -2.92799  1.000 45.02120 ? 286 LEU B CB  1 
ATOM   4419 C CG  . LEU B 1 286 ? -33.70923 -19.36664 -2.68773  1.000 50.02934 ? 286 LEU B CG  1 
ATOM   4420 C CD1 . LEU B 1 286 ? -34.19367 -19.76735 -1.30665  1.000 45.84685 ? 286 LEU B CD1 1 
ATOM   4421 C CD2 . LEU B 1 286 ? -34.38659 -20.17642 -3.79676  1.000 42.55557 ? 286 LEU B CD2 1 
ATOM   4422 N N   . LEU B 1 287 ? -35.28875 -15.73842 -4.65605  1.000 41.50613 ? 287 LEU B N   1 
ATOM   4423 C CA  . LEU B 1 287 ? -35.82360 -14.38448 -4.72150  1.000 44.14429 ? 287 LEU B CA  1 
ATOM   4424 C C   . LEU B 1 287 ? -36.05944 -13.89224 -3.29454  1.000 41.52487 ? 287 LEU B C   1 
ATOM   4425 O O   . LEU B 1 287 ? -36.92743 -14.40662 -2.59537  1.000 44.74061 ? 287 LEU B O   1 
ATOM   4426 C CB  . LEU B 1 287 ? -37.09525 -14.36241 -5.56323  1.000 43.10690 ? 287 LEU B CB  1 
ATOM   4427 C CG  . LEU B 1 287 ? -36.87249 -14.81155 -7.01169  1.000 42.00739 ? 287 LEU B CG  1 
ATOM   4428 C CD1 . LEU B 1 287 ? -38.18100 -15.02884 -7.76676  1.000 42.40578 ? 287 LEU B CD1 1 
ATOM   4429 C CD2 . LEU B 1 287 ? -35.97598 -13.81993 -7.74754  1.000 43.81160 ? 287 LEU B CD2 1 
ATOM   4430 N N   . GLU B 1 288 ? -35.28107 -12.89967 -2.86298  1.000 40.91227 ? 288 GLU B N   1 
ATOM   4431 C CA  . GLU B 1 288 ? -35.32234 -12.42513 -1.48143  1.000 39.87638 ? 288 GLU B CA  1 
ATOM   4432 C C   . GLU B 1 288 ? -36.49534 -11.48335 -1.24747  1.000 40.82493 ? 288 GLU B C   1 
ATOM   4433 O O   . GLU B 1 288 ? -36.69679 -10.52855 -2.00381  1.000 41.59779 ? 288 GLU B O   1 
ATOM   4434 C CB  . GLU B 1 288 ? -34.03072 -11.70199 -1.12290  1.000 40.92437 ? 288 GLU B CB  1 
ATOM   4435 C CG  . GLU B 1 288 ? -32.83365 -12.60787 -0.99779  1.000 50.71733 ? 288 GLU B CG  1 
ATOM   4436 C CD  . GLU B 1 288 ? -32.86566 -13.42177 0.28056   1.000 56.62247 ? 288 GLU B CD  1 
ATOM   4437 O OE1 . GLU B 1 288 ? -33.24726 -12.85627 1.33762   1.000 51.16537 ? 288 GLU B OE1 1 
ATOM   4438 O OE2 . GLU B 1 288 ? -32.50662 -14.61949 0.21271   1.000 56.24420 ? 288 GLU B OE2 1 
ATOM   4439 N N   . ASP B 1 289 ? -37.24964 -11.72178 -0.17560  1.000 35.03899 ? 289 ASP B N   1 
ATOM   4440 C CA  . ASP B 1 289 ? -38.38379 -10.85453 0.11428   1.000 38.06957 ? 289 ASP B CA  1 
ATOM   4441 C C   . ASP B 1 289 ? -38.32387 -10.20180 1.49274   1.000 34.29500 ? 289 ASP B C   1 
ATOM   4442 O O   . ASP B 1 289 ? -39.29013 -9.54878  1.88783   1.000 33.73833 ? 289 ASP B O   1 
ATOM   4443 C CB  . ASP B 1 289 ? -39.70888 -11.61486 -0.08236  1.000 35.53204 ? 289 ASP B CB  1 
ATOM   4444 C CG  . ASP B 1 289 ? -40.01841 -12.60767 1.03347   1.000 38.41110 ? 289 ASP B CG  1 
ATOM   4445 O OD1 . ASP B 1 289 ? -39.13043 -12.94885 1.84752   1.000 40.61186 ? 289 ASP B OD1 1 
ATOM   4446 O OD2 . ASP B 1 289 ? -41.18271 -13.04827 1.08083   1.000 39.04955 ? 289 ASP B OD2 1 
ATOM   4447 N N   . GLU B 1 290 ? -37.20154 -10.27551 2.20759   1.000 34.33122 ? 290 GLU B N   1 
ATOM   4448 C CA  . GLU B 1 290 ? -37.11072 -9.61413  3.50641   1.000 36.91012 ? 290 GLU B CA  1 
ATOM   4449 C C   . GLU B 1 290 ? -36.37910 -8.25872  3.43666   1.000 37.87062 ? 290 GLU B C   1 
ATOM   4450 O O   . GLU B 1 290 ? -35.77342 -7.82934  4.42292   1.000 35.23513 ? 290 GLU B O   1 
ATOM   4451 C CB  . GLU B 1 290 ? -36.48244 -10.56252 4.54148   1.000 36.69067 ? 290 GLU B CB  1 
ATOM   4452 C CG  . GLU B 1 290 ? -37.27639 -11.91462 4.68996   1.000 33.91161 ? 290 GLU B CG  1 
ATOM   4453 C CD  . GLU B 1 290 ? -37.49552 -12.41518 6.14570   1.000 42.70991 ? 290 GLU B CD  1 
ATOM   4454 O OE1 . GLU B 1 290 ? -36.75694 -11.99149 7.06168   1.000 39.98461 ? 290 GLU B OE1 1 
ATOM   4455 O OE2 . GLU B 1 290 ? -38.42655 -13.25876 6.36853   1.000 45.61495 ? 290 GLU B OE2 1 
ATOM   4456 N N   . PHE B 1 291 ? -36.47621 -7.55181  2.30344   1.000 32.77717 ? 291 PHE B N   1 
ATOM   4457 C CA  . PHE B 1 291 ? -36.00594 -6.16909  2.16069   1.000 35.92674 ? 291 PHE B CA  1 
ATOM   4458 C C   . PHE B 1 291 ? -37.17192 -5.27354  1.74247   1.000 37.36896 ? 291 PHE B C   1 
ATOM   4459 O O   . PHE B 1 291 ? -37.73560 -5.44938  0.65769   1.000 37.83074 ? 291 PHE B O   1 
ATOM   4460 C CB  . PHE B 1 291 ? -34.87696 -6.06234  1.12409   1.000 37.27780 ? 291 PHE B CB  1 
ATOM   4461 C CG  . PHE B 1 291 ? -33.58020 -6.68713  1.55990   1.000 41.02626 ? 291 PHE B CG  1 
ATOM   4462 C CD1 . PHE B 1 291 ? -32.68899 -5.98943  2.37038   1.000 44.39990 ? 291 PHE B CD1 1 
ATOM   4463 C CD2 . PHE B 1 291 ? -33.23794 -7.95354  1.14263   1.000 37.30020 ? 291 PHE B CD2 1 
ATOM   4464 C CE1 . PHE B 1 291 ? -31.48961 -6.56458  2.77206   1.000 44.61937 ? 291 PHE B CE1 1 
ATOM   4465 C CE2 . PHE B 1 291 ? -32.04399 -8.53120  1.54450   1.000 42.35724 ? 291 PHE B CE2 1 
ATOM   4466 C CZ  . PHE B 1 291 ? -31.17616 -7.83943  2.35889   1.000 41.86261 ? 291 PHE B CZ  1 
ATOM   4467 N N   . THR B 1 292 ? -37.52081 -4.30084  2.57652   1.000 36.18927 ? 292 THR B N   1 
ATOM   4468 C CA  . THR B 1 292 ? -38.51899 -3.34057  2.13807   1.000 35.19913 ? 292 THR B CA  1 
ATOM   4469 C C   . THR B 1 292 ? -37.91594 -2.33222  1.15406   1.000 39.97743 ? 292 THR B C   1 
ATOM   4470 O O   . THR B 1 292 ? -36.69934 -2.18000  1.07159   1.000 36.38544 ? 292 THR B O   1 
ATOM   4471 C CB  . THR B 1 292 ? -39.08543 -2.57476  3.32305   1.000 37.39893 ? 292 THR B CB  1 
ATOM   4472 O OG1 . THR B 1 292 ? -38.02683 -1.87509  3.98021   1.000 39.41689 ? 292 THR B OG1 1 
ATOM   4473 C CG2 . THR B 1 292 ? -39.78406 -3.49062  4.32122   1.000 36.19752 ? 292 THR B CG2 1 
ATOM   4474 N N   . PRO B 1 293 ? -38.76191 -1.62570  0.40265   1.000 37.20495 ? 293 PRO B N   1 
ATOM   4475 C CA  . PRO B 1 293 ? -38.27976 -0.47178  -0.36126  1.000 40.43615 ? 293 PRO B CA  1 
ATOM   4476 C C   . PRO B 1 293 ? -37.47515 0.49934   0.48482   1.000 44.13015 ? 293 PRO B C   1 
ATOM   4477 O O   . PRO B 1 293 ? -36.42707 0.97334   0.03208   1.000 38.77276 ? 293 PRO B O   1 
ATOM   4478 C CB  . PRO B 1 293 ? -39.58041 0.15748   -0.88105  1.000 37.76645 ? 293 PRO B CB  1 
ATOM   4479 C CG  . PRO B 1 293 ? -40.50601 -0.99868  -1.01975  1.000 37.55643 ? 293 PRO B CG  1 
ATOM   4480 C CD  . PRO B 1 293 ? -40.18360 -1.90981  0.14594   1.000 38.54650 ? 293 PRO B CD  1 
ATOM   4481 N N   . PHE B 1 294 ? -37.92537 0.78622   1.71495   1.000 41.18807 ? 294 PHE B N   1 
ATOM   4482 C CA  . PHE B 1 294 ? -37.15089 1.63916   2.61358   1.000 38.66982 ? 294 PHE B CA  1 
ATOM   4483 C C   . PHE B 1 294 ? -35.77404 1.04332   2.88273   1.000 41.44417 ? 294 PHE B C   1 
ATOM   4484 O O   . PHE B 1 294 ? -34.76526 1.75584   2.84719   1.000 40.44080 ? 294 PHE B O   1 
ATOM   4485 C CB  . PHE B 1 294 ? -37.90649 1.86480   3.92711   1.000 43.92189 ? 294 PHE B CB  1 
ATOM   4486 C CG  . PHE B 1 294 ? -37.11744 2.64931   4.95640   1.000 47.57447 ? 294 PHE B CG  1 
ATOM   4487 C CD1 . PHE B 1 294 ? -36.09493 2.04258   5.69218   1.000 49.31626 ? 294 PHE B CD1 1 
ATOM   4488 C CD2 . PHE B 1 294 ? -37.39938 3.98654   5.19421   1.000 46.81761 ? 294 PHE B CD2 1 
ATOM   4489 C CE1 . PHE B 1 294 ? -35.35370 2.76399   6.63010   1.000 51.60948 ? 294 PHE B CE1 1 
ATOM   4490 C CE2 . PHE B 1 294 ? -36.66844 4.71106   6.13173   1.000 48.90071 ? 294 PHE B CE2 1 
ATOM   4491 C CZ  . PHE B 1 294 ? -35.64423 4.09880   6.84815   1.000 48.40655 ? 294 PHE B CZ  1 
ATOM   4492 N N   . ASP B 1 295 ? -35.71232 -0.26444  3.17403   1.000 39.36097 ? 295 ASP B N   1 
ATOM   4493 C CA  . ASP B 1 295 ? -34.41634 -0.90836  3.39638   1.000 41.53675 ? 295 ASP B CA  1 
ATOM   4494 C C   . ASP B 1 295 ? -33.50090 -0.75509  2.18653   1.000 43.62064 ? 295 ASP B C   1 
ATOM   4495 O O   . ASP B 1 295 ? -32.27974 -0.65009  2.33754   1.000 43.74223 ? 295 ASP B O   1 
ATOM   4496 C CB  . ASP B 1 295 ? -34.59194 -2.39129  3.70135   1.000 37.58354 ? 295 ASP B CB  1 
ATOM   4497 C CG  . ASP B 1 295 ? -35.38150 -2.63973  4.97840   1.000 42.42145 ? 295 ASP B CG  1 
ATOM   4498 O OD1 . ASP B 1 295 ? -35.52508 -1.68753  5.78313   1.000 41.02631 ? 295 ASP B OD1 1 
ATOM   4499 O OD2 . ASP B 1 295 ? -35.84185 -3.79602  5.15991   1.000 36.57767 ? 295 ASP B OD2 1 
ATOM   4500 N N   . VAL B 1 296 ? -34.06913 -0.78333  0.97680   1.000 39.25479 ? 296 VAL B N   1 
ATOM   4501 C CA  . VAL B 1 296 ? -33.24865 -0.67996  -0.22722  1.000 39.99210 ? 296 VAL B CA  1 
ATOM   4502 C C   . VAL B 1 296 ? -32.67066 0.73028   -0.35169  1.000 44.11630 ? 296 VAL B C   1 
ATOM   4503 O O   . VAL B 1 296 ? -31.46100 0.90683   -0.53461  1.000 45.19134 ? 296 VAL B O   1 
ATOM   4504 C CB  . VAL B 1 296 ? -34.06805 -1.08192  -1.46532  1.000 37.81243 ? 296 VAL B CB  1 
ATOM   4505 C CG1 . VAL B 1 296 ? -33.28933 -0.81912  -2.75572  1.000 41.14858 ? 296 VAL B CG1 1 
ATOM   4506 C CG2 . VAL B 1 296 ? -34.48199 -2.54593  -1.38235  1.000 37.33813 ? 296 VAL B CG2 1 
ATOM   4507 N N   . VAL B 1 297 ? -33.51875 1.74949   -0.19060  1.000 42.76287 ? 297 VAL B N   1 
ATOM   4508 C CA  . VAL B 1 297 ? -33.08114 3.13970   -0.29967  1.000 49.89363 ? 297 VAL B CA  1 
ATOM   4509 C C   . VAL B 1 297 ? -32.02100 3.45392   0.74828   1.000 51.76396 ? 297 VAL B C   1 
ATOM   4510 O O   . VAL B 1 297 ? -30.96405 4.00936   0.43534   1.000 50.23717 ? 297 VAL B O   1 
ATOM   4511 C CB  . VAL B 1 297 ? -34.28479 4.09098   -0.17443  1.000 46.43354 ? 297 VAL B CB  1 
ATOM   4512 C CG1 . VAL B 1 297 ? -33.80612 5.49871   0.03975   1.000 46.85372 ? 297 VAL B CG1 1 
ATOM   4513 C CG2 . VAL B 1 297 ? -35.17401 4.00553   -1.40682  1.000 48.36903 ? 297 VAL B CG2 1 
ATOM   4514 N N   . ARG B 1 298 ? -32.30003 3.11333   2.00978   1.000 47.40827 ? 298 ARG B N   1 
ATOM   4515 C CA  . ARG B 1 298 ? -31.37840 3.37650   3.11524   1.000 50.25239 ? 298 ARG B CA  1 
ATOM   4516 C C   . ARG B 1 298 ? -29.96089 2.91438   2.80274   1.000 53.17601 ? 298 ARG B C   1 
ATOM   4517 O O   . ARG B 1 298 ? -28.98625 3.52955   3.25551   1.000 54.05379 ? 298 ARG B O   1 
ATOM   4518 C CB  . ARG B 1 298 ? -31.91661 2.69001   4.38871   1.000 49.76560 ? 298 ARG B CB  1 
ATOM   4519 C CG  . ARG B 1 298 ? -30.90629 2.31511   5.49216   1.000 51.45587 ? 298 ARG B CG  1 
ATOM   4520 C CD  . ARG B 1 298 ? -31.56903 1.34584   6.52731   1.000 56.50406 ? 298 ARG B CD  1 
ATOM   4521 N NE  . ARG B 1 298 ? -30.65770 0.89471   7.58061   1.000 60.48149 ? 298 ARG B NE  1 
ATOM   4522 C CZ  . ARG B 1 298 ? -30.80889 -0.20608  8.31534   1.000 52.38663 ? 298 ARG B CZ  1 
ATOM   4523 N NH1 . ARG B 1 298 ? -31.81821 -1.04331  8.12176   1.000 52.20357 ? 298 ARG B NH1 1 
ATOM   4524 N NH2 . ARG B 1 298 ? -29.92245 -0.47132  9.27558   1.000 50.54406 ? 298 ARG B NH2 1 
ATOM   4525 N N   . GLN B 1 299 ? -29.82406 1.84954   2.01787   1.000 53.10247 ? 299 GLN B N   1 
ATOM   4526 C CA  . GLN B 1 299 ? -28.53870 1.19870   1.81658   1.000 50.73316 ? 299 GLN B CA  1 
ATOM   4527 C C   . GLN B 1 299 ? -27.91889 1.47633   0.45263   1.000 55.49579 ? 299 GLN B C   1 
ATOM   4528 O O   . GLN B 1 299 ? -26.69837 1.33063   0.29904   1.000 57.69586 ? 299 GLN B O   1 
ATOM   4529 C CB  . GLN B 1 299 ? -28.69913 -0.31240  2.00441   1.000 47.38851 ? 299 GLN B CB  1 
ATOM   4530 C CG  . GLN B 1 299 ? -27.47966 -0.97602  2.54776   1.000 46.42514 ? 299 GLN B CG  1 
ATOM   4531 C CD  . GLN B 1 299 ? -27.63125 -2.46323  2.66238   1.000 47.33566 ? 299 GLN B CD  1 
ATOM   4532 O OE1 . GLN B 1 299 ? -26.69430 -3.20245  2.37444   1.000 46.18607 ? 299 GLN B OE1 1 
ATOM   4533 N NE2 . GLN B 1 299 ? -28.81481 -2.92438  3.10364   1.000 41.79508 ? 299 GLN B NE2 1 
ATOM   4534 N N   . CYS B 1 300 ? -28.72209 1.84134   -0.53985  1.000 52.41012 ? 300 CYS B N   1 
ATOM   4535 C CA  . CYS B 1 300 ? -28.23690 2.23716   -1.84830  1.000 56.37252 ? 300 CYS B CA  1 
ATOM   4536 C C   . CYS B 1 300 ? -28.22395 3.77572   -1.92350  1.000 59.79520 ? 300 CYS B C   1 
ATOM   4537 O O   . CYS B 1 300 ? -28.43175 4.46625   -0.91519  1.000 58.50485 ? 300 CYS B O   1 
ATOM   4538 C CB  . CYS B 1 300 ? -29.09021 1.56139   -2.92586  1.000 51.40789 ? 300 CYS B CB  1 
ATOM   4539 S SG  . CYS B 1 300 ? -29.22031 -0.30409  -2.78677  1.000 49.17600 ? 300 CYS B SG  1 
ATOM   4540 N N   . SER B 1 301 ? -27.95914 4.32824   -3.11040  1.000 60.30153 ? 301 SER B N   1 
ATOM   4541 C CA  . SER B 1 301 ? -27.82885 5.79490   -3.25279  1.000 65.57265 ? 301 SER B CA  1 
ATOM   4542 C C   . SER B 1 301 ? -27.75385 6.25438   -4.70675  1.000 68.75443 ? 301 SER B C   1 
ATOM   4543 O O   . SER B 1 301 ? -26.98560 7.15828   -5.04733  1.000 69.51237 ? 301 SER B O   1 
ATOM   4544 C CB  . SER B 1 301 ? -26.59117 6.30495   -2.50796  1.000 60.56885 ? 301 SER B CB  1 
HETATM 4545 C C7  . UED C 2 .   ? -13.32650 3.42975   -5.73014  1.000 52.96384 ? 401 UED A C7  1 
HETATM 4546 O O8  . UED C 2 .   ? -12.33645 4.16585   -5.01055  1.000 46.83803 ? 401 UED A O8  1 
HETATM 4547 C C9  . UED C 2 .   ? -12.29397 4.09272   -3.66090  1.000 50.08717 ? 401 UED A C9  1 
HETATM 4548 O O10 . UED C 2 .   ? -13.00943 3.35213   -2.95650  1.000 48.29507 ? 401 UED A O10 1 
HETATM 4549 C C1  . UED C 2 .   ? -14.73153 4.02942   -5.64359  1.000 55.65875 ? 401 UED A C1  1 
HETATM 4550 C C2  . UED C 2 .   ? -14.95588 5.33561   -5.18610  1.000 56.39739 ? 401 UED A C2  1 
HETATM 4551 C C3  . UED C 2 .   ? -16.25439 5.84974   -5.13448  1.000 59.00644 ? 401 UED A C3  1 
HETATM 4552 C C4  . UED C 2 .   ? -17.33606 5.05970   -5.53694  1.000 61.25541 ? 401 UED A C4  1 
HETATM 4553 C C5  . UED C 2 .   ? -17.12767 3.75928   -5.99344  1.000 60.71313 ? 401 UED A C5  1 
HETATM 4554 C C6  . UED C 2 .   ? -15.82788 3.24869   -6.04790  1.000 61.36487 ? 401 UED A C6  1 
HETATM 4555 N N11 . UED C 2 .   ? -11.33294 4.98301   -3.19091  1.000 44.64885 ? 401 UED A N11 1 
HETATM 4556 C C12 . UED C 2 .   ? -11.26519 5.35484   -1.76683  1.000 43.97723 ? 401 UED A C12 1 
HETATM 4557 C C17 . UED C 2 .   ? -12.65756 5.76112   -1.20853  1.000 45.22029 ? 401 UED A C17 1 
HETATM 4558 O O18 . UED C 2 .   ? -13.37340 6.48641   -1.89847  1.000 48.23459 ? 401 UED A O18 1 
HETATM 4559 C C13 . UED C 2 .   ? -10.23819 6.49603   -1.54063  1.000 43.75227 ? 401 UED A C13 1 
HETATM 4560 C C14 . UED C 2 .   ? -8.75094  6.10445   -1.78611  1.000 51.65111 ? 401 UED A C14 1 
HETATM 4561 C C15 . UED C 2 .   ? -8.19170  5.21471   -0.64540  1.000 49.63913 ? 401 UED A C15 1 
HETATM 4562 C C16 . UED C 2 .   ? -7.80028  7.30241   -2.07880  1.000 53.19290 ? 401 UED A C16 1 
HETATM 4563 N N19 . UED C 2 .   ? -13.00969 5.26662   -0.00125  1.000 39.20975 ? 401 UED A N19 1 
HETATM 4564 C C20 . UED C 2 .   ? -14.27054 5.50034   0.72221   1.000 39.86344 ? 401 UED A C20 1 
HETATM 4565 C C21 . UED C 2 .   ? -13.89152 6.13770   2.08260   1.000 39.29243 ? 401 UED A C21 1 
HETATM 4566 O O22 . UED C 2 .   ? -14.97712 6.79799   2.70922   1.000 50.47881 ? 401 UED A O22 1 
HETATM 4567 C C24 . UED C 2 .   ? -15.13571 4.19257   0.77572   1.000 38.33590 ? 401 UED A C24 1 
HETATM 4568 C C25 . UED C 2 .   ? -15.61798 3.64229   -0.60327  1.000 38.78664 ? 401 UED A C25 1 
HETATM 4569 C C26 . UED C 2 .   ? -16.61652 4.57366   -1.29080  1.000 42.98551 ? 401 UED A C26 1 
HETATM 4570 C C27 . UED C 2 .   ? -17.62663 3.65865   -1.97280  1.000 49.77590 ? 401 UED A C27 1 
HETATM 4571 N N28 . UED C 2 .   ? -17.51867 2.42617   -1.21059  1.000 39.66411 ? 401 UED A N28 1 
HETATM 4572 C C29 . UED C 2 .   ? -16.42764 2.33474   -0.43082  1.000 41.48783 ? 401 UED A C29 1 
HETATM 4573 O O30 . UED C 2 .   ? -16.11436 1.39232   0.28294   1.000 42.32705 ? 401 UED A O30 1 
HETATM 4574 H H1  . UED C 2 .   ? -13.04235 3.36983   -6.78282  1.000 63.55661 ? 401 UED A H1  1 
HETATM 4575 H H2  . UED C 2 .   ? -13.36559 2.40600   -5.35216  1.000 63.55661 ? 401 UED A H2  1 
HETATM 4576 H H3  . UED C 2 .   ? -14.12652 5.95005   -4.87167  1.000 67.67686 ? 401 UED A H3  1 
HETATM 4577 H H4  . UED C 2 .   ? -16.42236 6.85729   -4.78371  1.000 70.80773 ? 401 UED A H4  1 
HETATM 4578 H H5  . UED C 2 .   ? -18.33801 5.46044   -5.49338  1.000 73.50649 ? 401 UED A H5  1 
HETATM 4579 H H6  . UED C 2 .   ? -17.96616 3.14967   -6.30334  1.000 72.85576 ? 401 UED A H6  1 
HETATM 4580 H H7  . UED C 2 .   ? -15.66946 2.24013   -6.40627  1.000 73.63785 ? 401 UED A H7  1 
HETATM 4581 H H8  . UED C 2 .   ? -10.66511 5.38623   -3.83398  1.000 53.57862 ? 401 UED A H8  1 
HETATM 4582 H H9  . UED C 2 .   ? -10.89631 4.49055   -1.20863  1.000 52.77267 ? 401 UED A H9  1 
HETATM 4583 H H10 . UED C 2 .   ? -10.49561 7.33758   -2.18716  1.000 52.50272 ? 401 UED A H10 1 
HETATM 4584 H H11 . UED C 2 .   ? -10.34351 6.87029   -0.52019  1.000 52.50272 ? 401 UED A H11 1 
HETATM 4585 H H12 . UED C 2 .   ? -8.75943  5.54810   -2.72456  1.000 61.98133 ? 401 UED A H12 1 
HETATM 4586 H H13 . UED C 2 .   ? -8.76432  5.32433   0.27675   1.000 59.56696 ? 401 UED A H13 1 
HETATM 4587 H H14 . UED C 2 .   ? -8.21220  4.15541   -0.90566  1.000 59.56696 ? 401 UED A H14 1 
HETATM 4588 H H15 . UED C 2 .   ? -7.15632  5.46075   -0.40516  1.000 59.56696 ? 401 UED A H15 1 
HETATM 4589 H H16 . UED C 2 .   ? -6.80571  6.98459   -2.39171  1.000 63.83148 ? 401 UED A H16 1 
HETATM 4590 H H17 . UED C 2 .   ? -8.17177  7.95132   -2.87191  1.000 63.83148 ? 401 UED A H17 1 
HETATM 4591 H H18 . UED C 2 .   ? -7.65132  7.94423   -1.21048  1.000 63.83148 ? 401 UED A H18 1 
HETATM 4592 H H19 . UED C 2 .   ? -12.34738 4.66870   0.47196   1.000 47.05170 ? 401 UED A H19 1 
HETATM 4593 H H20 . UED C 2 .   ? -14.91965 6.24437   0.25114   1.000 47.83612 ? 401 UED A H20 1 
HETATM 4594 H H21 . UED C 2 .   ? -16.00387 4.38367   1.41168   1.000 46.00308 ? 401 UED A H21 1 
HETATM 4595 H H22 . UED C 2 .   ? -14.55650 3.42114   1.28959   1.000 46.00308 ? 401 UED A H22 1 
HETATM 4596 H H23 . UED C 2 .   ? -14.76652 3.41415   -1.24611  1.000 46.54397 ? 401 UED A H23 1 
HETATM 4597 H H24 . UED C 2 .   ? -17.12587 5.23216   -0.58566  1.000 51.58262 ? 401 UED A H24 1 
HETATM 4598 H H25 . UED C 2 .   ? -16.14182 5.22166   -2.02906  1.000 51.58262 ? 401 UED A H25 1 
HETATM 4599 H H26 . UED C 2 .   ? -18.64400 4.04615   -1.91888  1.000 59.73108 ? 401 UED A H26 1 
HETATM 4600 H H27 . UED C 2 .   ? -17.38412 3.47577   -3.01963  1.000 59.73108 ? 401 UED A H27 1 
HETATM 4601 H H28 . UED C 2 .   ? -18.21663 1.69703   -1.26839  1.000 47.59693 ? 401 UED A H28 1 
HETATM 4602 H H31 . UED C 2 .   ? -14.65296 7.60587   3.11994   1.000 60.57457 ? 401 UED A H31 1 
HETATM 4603 C C7  . UED D 2 .   ? -42.88045 -24.53591 22.03241  1.000 54.84870 ? 401 UED B C7  1 
HETATM 4604 O O8  . UED D 2 .   ? -43.24642 -23.84991 23.23093  1.000 47.99838 ? 401 UED B O8  1 
HETATM 4605 C C9  . UED D 2 .   ? -42.99269 -22.52446 23.33997  1.000 54.16487 ? 401 UED B C9  1 
HETATM 4606 O O10 . UED D 2 .   ? -42.34126 -21.87591 22.51940  1.000 50.82234 ? 401 UED B O10 1 
HETATM 4607 C C1  . UED D 2 .   ? -41.41756 -24.98116 22.04984  1.000 60.34632 ? 401 UED B C1  1 
HETATM 4608 C C2  . UED D 2 .   ? -40.70912 -24.99210 23.26296  1.000 61.21220 ? 401 UED B C2  1 
HETATM 4609 C C3  . UED D 2 .   ? -39.37296 -25.40338 23.28956  1.000 58.32318 ? 401 UED B C3  1 
HETATM 4610 C C4  . UED D 2 .   ? -38.74698 -25.81382 22.10663  1.000 60.80716 ? 401 UED B C4  1 
HETATM 4611 C C5  . UED D 2 .   ? -39.43913 -25.80582 20.89296  1.000 58.73715 ? 401 UED B C5  1 
HETATM 4612 C C6  . UED D 2 .   ? -40.77552 -25.39193 20.86413  1.000 59.29314 ? 401 UED B C6  1 
HETATM 4613 N N11 . UED D 2 .   ? -43.55152 -22.00565 24.50017  1.000 54.00576 ? 401 UED B N11 1 
HETATM 4614 C C12 . UED D 2 .   ? -42.98483 -20.80659 25.14157  1.000 51.36982 ? 401 UED B C12 1 
HETATM 4615 C C17 . UED D 2 .   ? -41.45163 -20.87164 25.29886  1.000 49.03497 ? 401 UED B C17 1 
HETATM 4616 O O18 . UED D 2 .   ? -40.89443 -21.90940 25.62188  1.000 53.09183 ? 401 UED B O18 1 
HETATM 4617 C C13 . UED D 2 .   ? -43.77737 -20.56507 26.45281  1.000 52.41870 ? 401 UED B C13 1 
HETATM 4618 C C14 . UED D 2 .   ? -45.29753 -20.79845 26.28178  1.000 55.43260 ? 401 UED B C14 1 
HETATM 4619 C C15 . UED D 2 .   ? -45.96393 -20.07928 25.09451  1.000 53.74860 ? 401 UED B C15 1 
HETATM 4620 C C16 . UED D 2 .   ? -46.05075 -20.48559 27.59152  1.000 56.35840 ? 401 UED B C16 1 
HETATM 4621 N N19 . UED D 2 .   ? -40.83148 -19.71638 25.00960  1.000 49.00135 ? 401 UED B N19 1 
HETATM 4622 C C20 . UED D 2 .   ? -39.39675 -19.43526 25.03471  1.000 47.90024 ? 401 UED B C20 1 
HETATM 4623 C C21 . UED D 2 .   ? -39.20046 -18.17948 25.91152  1.000 47.54068 ? 401 UED B C21 1 
HETATM 4624 O O22 . UED D 2 .   ? -37.91356 -18.09401 26.50024  1.000 55.40905 ? 401 UED B O22 1 
HETATM 4625 C C24 . UED D 2 .   ? -38.90126 -19.35132 23.57095  1.000 44.22695 ? 401 UED B C24 1 
HETATM 4626 C C25 . UED D 2 .   ? -38.98172 -20.63094 22.69373  1.000 45.77406 ? 401 UED B C25 1 
HETATM 4627 C C26 . UED D 2 .   ? -38.25265 -21.84850 23.23407  1.000 50.38547 ? 401 UED B C26 1 
HETATM 4628 C C27 . UED D 2 .   ? -37.27270 -22.27493 22.15843  1.000 52.93995 ? 401 UED B C27 1 
HETATM 4629 N N28 . UED D 2 .   ? -37.33908 -21.22189 21.15600  1.000 47.37051 ? 401 UED B N28 1 
HETATM 4630 C C29 . UED D 2 .   ? -38.27278 -20.28227 21.37268  1.000 47.73229 ? 401 UED B C29 1 
HETATM 4631 O O30 . UED D 2 .   ? -38.51419 -19.30536 20.66600  1.000 44.04131 ? 401 UED B O30 1 
HETATM 4632 H H1  . UED D 2 .   ? -43.03486 -23.86970 21.18491  1.000 65.81844 ? 401 UED B H1  1 
HETATM 4633 H H2  . UED D 2 .   ? -43.51396 -25.41490 21.92304  1.000 65.81844 ? 401 UED B H2  1 
HETATM 4634 H H3  . UED D 2 .   ? -41.20005 -24.68064 24.18141  1.000 73.45464 ? 401 UED B H3  1 
HETATM 4635 H H4  . UED D 2 .   ? -38.82145 -25.40430 24.22741  1.000 69.98781 ? 401 UED B H4  1 
HETATM 4636 H H5  . UED D 2 .   ? -37.71018 -26.14261 22.13271  1.000 72.96859 ? 401 UED B H5  1 
HETATM 4637 H H6  . UED D 2 .   ? -38.94280 -26.11909 19.97685  1.000 70.48458 ? 401 UED B H6  1 
HETATM 4638 H H7  . UED D 2 .   ? -41.32122 -25.38714 19.92289  1.000 71.15176 ? 401 UED B H7  1 
HETATM 4639 H H8  . UED D 2 .   ? -44.35405 -22.45448 24.90827  1.000 64.80691 ? 401 UED B H8  1 
HETATM 4640 H H9  . UED D 2 .   ? -43.14263 -19.92119 24.52749  1.000 61.64378 ? 401 UED B H9  1 
HETATM 4641 H H10 . UED D 2 .   ? -43.61200 -19.54030 26.78206  1.000 62.90243 ? 401 UED B H10 1 
HETATM 4642 H H11 . UED D 2 .   ? -43.40095 -21.23754 27.22223  1.000 62.90243 ? 401 UED B H11 1 
HETATM 4643 H H12 . UED D 2 .   ? -45.37373 -21.86183 26.05966  1.000 66.51911 ? 401 UED B H12 1 
HETATM 4644 H H13 . UED D 2 .   ? -46.97447 -19.78474 25.36981  1.000 64.49833 ? 401 UED B H13 1 
HETATM 4645 H H14 . UED D 2 .   ? -45.38604 -19.19450 24.83578  1.000 64.49833 ? 401 UED B H14 1 
HETATM 4646 H H15 . UED D 2 .   ? -46.00212 -20.75048 24.23907  1.000 64.49833 ? 401 UED B H15 1 
HETATM 4647 H H16 . UED D 2 .   ? -47.07766 -20.83951 27.51331  1.000 67.63008 ? 401 UED B H16 1 
HETATM 4648 H H17 . UED D 2 .   ? -45.55678 -20.98617 28.42299  1.000 67.63008 ? 401 UED B H17 1 
HETATM 4649 H H18 . UED D 2 .   ? -46.04967 -19.41019 27.76308  1.000 67.63008 ? 401 UED B H18 1 
HETATM 4650 H H19 . UED D 2 .   ? -41.42731 -18.95088 24.74305  1.000 58.80162 ? 401 UED B H19 1 
HETATM 4651 H H20 . UED D 2 .   ? -38.80495 -20.21080 25.51868  1.000 57.48029 ? 401 UED B H20 1 
HETATM 4652 H H21 . UED D 2 .   ? -37.85845 -19.03503 23.59549  1.000 53.07234 ? 401 UED B H21 1 
HETATM 4653 H H22 . UED D 2 .   ? -39.48118 -18.57453 23.07258  1.000 53.07234 ? 401 UED B H22 1 
HETATM 4654 H H23 . UED D 2 .   ? -40.01308 -20.93282 22.53027  1.000 54.92887 ? 401 UED B H23 1 
HETATM 4655 H H24 . UED D 2 .   ? -38.96109 -22.64744 23.42653  1.000 60.46256 ? 401 UED B H24 1 
HETATM 4656 H H25 . UED D 2 .   ? -37.71614 -21.58548 24.13972  1.000 60.46256 ? 401 UED B H25 1 
HETATM 4657 H H26 . UED D 2 .   ? -37.58003 -23.22468 21.72568  1.000 63.52794 ? 401 UED B H26 1 
HETATM 4658 H H27 . UED D 2 .   ? -36.26753 -22.33821 22.56998  1.000 63.52794 ? 401 UED B H27 1 
HETATM 4659 H H28 . UED D 2 .   ? -36.72770 -21.19963 20.35615  1.000 56.84461 ? 401 UED B H28 1 
HETATM 4660 H H29 . UED D 2 .   ? -39.95054 -18.17743 26.69963  1.000 57.04882 ? 401 UED B H29 1 
HETATM 4661 H H31 . UED D 2 .   ? -37.98402 -17.86068 27.41640  1.000 66.49086 ? 401 UED B H31 1 
HETATM 4662 O O   . HOH E 3 .   ? -21.10938 -40.59744 10.72196  1.000 44.54268 ? 501 HOH A O   1 
HETATM 4663 O O   . HOH E 3 .   ? -15.48946 16.55639  11.41261  1.000 48.99527 ? 502 HOH A O   1 
HETATM 4664 O O   . HOH E 3 .   ? -11.43372 19.01963  16.29304  1.000 57.00318 ? 503 HOH A O   1 
HETATM 4665 O O   . HOH E 3 .   ? -9.03600  -11.54963 19.93519  1.000 61.52391 ? 504 HOH A O   1 
HETATM 4666 O O   . HOH E 3 .   ? -17.88845 1.66926   24.16771  1.000 51.82844 ? 505 HOH A O   1 
HETATM 4667 O O   . HOH E 3 .   ? -12.31348 -41.87437 0.01286   1.000 51.46248 ? 506 HOH A O   1 
HETATM 4668 O O   . HOH E 3 .   ? -32.31250 -26.70735 6.59213   1.000 42.57258 ? 507 HOH A O   1 
HETATM 4669 O O   . HOH E 3 .   ? -20.92112 -21.28523 6.36876   1.000 37.97098 ? 508 HOH A O   1 
HETATM 4670 O O   . HOH E 3 .   ? -17.24216 -11.20542 3.20907   1.000 35.70547 ? 509 HOH A O   1 
HETATM 4671 O O   . HOH E 3 .   ? -6.15574  -16.85628 1.43132   1.000 46.94321 ? 510 HOH A O   1 
HETATM 4672 O O   . HOH E 3 .   ? -27.12314 -26.60054 20.24088  1.000 58.47743 ? 511 HOH A O   1 
HETATM 4673 O O   . HOH E 3 .   ? -21.55105 -12.96307 6.07717   1.000 49.01725 ? 512 HOH A O   1 
HETATM 4674 O O   . HOH E 3 .   ? -19.46826 -17.77660 -0.42392  1.000 46.44815 ? 513 HOH A O   1 
HETATM 4675 O O   . HOH E 3 .   ? -3.07957  17.21805  2.03941   1.000 54.89400 ? 514 HOH A O   1 
HETATM 4676 O O   . HOH E 3 .   ? -23.40588 1.18598   4.59207   1.000 43.02001 ? 515 HOH A O   1 
HETATM 4677 O O   . HOH E 3 .   ? -37.13278 -23.63095 1.09119   1.000 59.60142 ? 516 HOH A O   1 
HETATM 4678 O O   . HOH E 3 .   ? -20.25154 -44.96718 5.26823   1.000 56.24926 ? 517 HOH A O   1 
HETATM 4679 O O   . HOH E 3 .   ? -15.29008 13.61737  2.45802   1.000 56.83402 ? 518 HOH A O   1 
HETATM 4680 O O   . HOH E 3 .   ? 1.59629   18.06198  17.78597  1.000 59.47558 ? 519 HOH A O   1 
HETATM 4681 O O   . HOH E 3 .   ? -8.76714  -5.97676  2.31345   1.000 36.95665 ? 520 HOH A O   1 
HETATM 4682 O O   . HOH E 3 .   ? -14.11126 -38.09730 9.78058   1.000 50.15822 ? 521 HOH A O   1 
HETATM 4683 O O   . HOH E 3 .   ? -2.24678  1.15182   15.57973  1.000 53.99220 ? 522 HOH A O   1 
HETATM 4684 O O   . HOH E 3 .   ? -6.79916  -10.48428 -3.85246  1.000 46.90628 ? 523 HOH A O   1 
HETATM 4685 O O   . HOH E 3 .   ? -18.37115 10.07473  6.96491   1.000 41.57361 ? 524 HOH A O   1 
HETATM 4686 O O   . HOH E 3 .   ? -2.70185  -2.99043  -5.52857  1.000 44.80359 ? 525 HOH A O   1 
HETATM 4687 O O   . HOH E 3 .   ? -26.22511 1.65664   6.16438   1.000 53.94252 ? 526 HOH A O   1 
HETATM 4688 O O   . HOH E 3 .   ? -34.61226 -24.60392 4.06151   1.000 46.83866 ? 527 HOH A O   1 
HETATM 4689 O O   . HOH E 3 .   ? -17.77365 -13.44168 13.94269  1.000 44.94988 ? 528 HOH A O   1 
HETATM 4690 O O   . HOH E 3 .   ? -5.68323  -25.58741 7.72773   1.000 50.94823 ? 529 HOH A O   1 
HETATM 4691 O O   . HOH E 3 .   ? -9.38831  -18.96489 9.17075   1.000 54.30588 ? 530 HOH A O   1 
HETATM 4692 O O   . HOH E 3 .   ? -12.20381 21.35836  -1.23940  1.000 70.05986 ? 531 HOH A O   1 
HETATM 4693 O O   . HOH E 3 .   ? -4.56961  13.13699  26.23866  1.000 64.94008 ? 532 HOH A O   1 
HETATM 4694 O O   . HOH E 3 .   ? -18.15559 -44.57050 0.98629   1.000 56.81839 ? 533 HOH A O   1 
HETATM 4695 O O   . HOH E 3 .   ? -0.71515  22.87012  15.76591  1.000 56.09635 ? 534 HOH A O   1 
HETATM 4696 O O   . HOH E 3 .   ? -19.58550 -6.48106  -1.70015  1.000 51.69478 ? 535 HOH A O   1 
HETATM 4697 O O   . HOH E 3 .   ? -27.99472 2.19506   19.06373  1.000 42.57169 ? 536 HOH A O   1 
HETATM 4698 O O   . HOH E 3 .   ? -8.21733  -17.42851 -3.34927  1.000 55.25088 ? 537 HOH A O   1 
HETATM 4699 O O   . HOH E 3 .   ? -5.94350  -5.02721  14.12015  1.000 44.31627 ? 538 HOH A O   1 
HETATM 4700 O O   . HOH E 3 .   ? -10.34564 -22.36590 4.06768   1.000 48.77668 ? 539 HOH A O   1 
HETATM 4701 O O   . HOH E 3 .   ? -22.65611 -14.43816 20.99202  1.000 55.70346 ? 540 HOH A O   1 
HETATM 4702 O O   . HOH E 3 .   ? -29.56671 -35.70677 13.74791  1.000 46.44979 ? 541 HOH A O   1 
HETATM 4703 O O   . HOH E 3 .   ? -7.69505  19.65456  16.19645  1.000 56.60067 ? 542 HOH A O   1 
HETATM 4704 O O   . HOH E 3 .   ? -6.11018  5.27232   3.63961   1.000 39.16054 ? 543 HOH A O   1 
HETATM 4705 O O   . HOH E 3 .   ? -16.23538 -16.39111 -3.56021  1.000 51.73683 ? 544 HOH A O   1 
HETATM 4706 O O   . HOH E 3 .   ? -9.42735  -36.87619 12.48716  1.000 54.14555 ? 545 HOH A O   1 
HETATM 4707 O O   . HOH E 3 .   ? -14.42771 -21.19863 14.34735  1.000 44.69497 ? 546 HOH A O   1 
HETATM 4708 O O   . HOH E 3 .   ? 7.53049   17.45165  -1.99569  1.000 49.37208 ? 547 HOH A O   1 
HETATM 4709 O O   . HOH E 3 .   ? -7.90812  1.57895   28.11988  1.000 58.51253 ? 548 HOH A O   1 
HETATM 4710 O O   . HOH E 3 .   ? -12.90940 -20.66923 8.88783   1.000 41.70062 ? 549 HOH A O   1 
HETATM 4711 O O   . HOH E 3 .   ? -21.22450 5.86921   -2.77901  1.000 47.48595 ? 550 HOH A O   1 
HETATM 4712 O O   . HOH E 3 .   ? 1.87551   13.76017  -2.81170  1.000 51.25446 ? 551 HOH A O   1 
HETATM 4713 O O   . HOH E 3 .   ? -17.50014 1.44905   12.92181  1.000 44.55995 ? 552 HOH A O   1 
HETATM 4714 O O   . HOH E 3 .   ? -22.91457 -38.56282 4.65342   1.000 39.31152 ? 553 HOH A O   1 
HETATM 4715 O O   . HOH E 3 .   ? -20.94244 -15.38128 10.72029  1.000 40.08503 ? 554 HOH A O   1 
HETATM 4716 O O   . HOH E 3 .   ? -16.75324 -27.94748 16.11483  1.000 51.89751 ? 555 HOH A O   1 
HETATM 4717 O O   . HOH E 3 .   ? -14.07548 -15.17183 13.39747  1.000 41.52669 ? 556 HOH A O   1 
HETATM 4718 O O   . HOH E 3 .   ? -23.53207 -17.08167 14.94624  1.000 46.74438 ? 557 HOH A O   1 
HETATM 4719 O O   . HOH E 3 .   ? -15.33844 -35.20077 17.52976  1.000 53.18584 ? 558 HOH A O   1 
HETATM 4720 O O   . HOH E 3 .   ? -28.45514 -20.55207 5.81399   1.000 39.96609 ? 559 HOH A O   1 
HETATM 4721 O O   . HOH E 3 .   ? -4.34486  -12.43350 7.53128   1.000 47.70608 ? 560 HOH A O   1 
HETATM 4722 O O   . HOH E 3 .   ? -21.81973 -4.25781  22.64300  1.000 48.63744 ? 561 HOH A O   1 
HETATM 4723 O O   . HOH E 3 .   ? 2.98548   17.31238  10.51375  1.000 49.68421 ? 562 HOH A O   1 
HETATM 4724 O O   . HOH E 3 .   ? 4.02850   14.52961  14.67177  1.000 52.89507 ? 563 HOH A O   1 
HETATM 4725 O O   . HOH E 3 .   ? -3.35721  -10.71450 15.60711  1.000 46.33658 ? 564 HOH A O   1 
HETATM 4726 O O   . HOH E 3 .   ? -19.60094 11.17717  16.71889  1.000 54.31475 ? 565 HOH A O   1 
HETATM 4727 O O   . HOH E 3 .   ? -13.74193 -10.73021 -4.24884  1.000 46.30773 ? 566 HOH A O   1 
HETATM 4728 O O   . HOH E 3 .   ? -2.64429  -6.24011  -6.45317  1.000 57.08652 ? 567 HOH A O   1 
HETATM 4729 O O   . HOH E 3 .   ? -3.68179  -8.41539  20.44782  1.000 52.23341 ? 568 HOH A O   1 
HETATM 4730 O O   . HOH E 3 .   ? -0.37307  -2.38957  3.71591   1.000 36.08845 ? 569 HOH A O   1 
HETATM 4731 O O   . HOH E 3 .   ? -31.30415 -33.70920 13.10308  1.000 50.64712 ? 570 HOH A O   1 
HETATM 4732 O O   . HOH E 3 .   ? -8.56975  -39.70147 5.08573   1.000 51.63000 ? 571 HOH A O   1 
HETATM 4733 O O   . HOH E 3 .   ? -15.75168 -16.79497 14.39550  1.000 45.83819 ? 572 HOH A O   1 
HETATM 4734 O O   . HOH E 3 .   ? -3.59043  -5.06202  20.70037  1.000 50.27292 ? 573 HOH A O   1 
HETATM 4735 O O   . HOH E 3 .   ? -20.46294 -38.95025 -1.63387  1.000 45.75856 ? 574 HOH A O   1 
HETATM 4736 O O   . HOH E 3 .   ? -29.80816 -13.35392 8.01538   1.000 50.62619 ? 575 HOH A O   1 
HETATM 4737 O O   . HOH E 3 .   ? -14.97676 -37.08085 12.73501  1.000 54.05647 ? 576 HOH A O   1 
HETATM 4738 O O   . HOH E 3 .   ? -21.75484 -7.41977  -0.69628  1.000 49.71292 ? 577 HOH A O   1 
HETATM 4739 O O   . HOH E 3 .   ? 0.90613   -1.14451  16.62839  1.000 50.45959 ? 578 HOH A O   1 
HETATM 4740 O O   . HOH E 3 .   ? -0.23010  -5.17114  3.94093   1.000 44.46717 ? 579 HOH A O   1 
HETATM 4741 O O   . HOH E 3 .   ? -11.59359 -9.73275  15.47755  1.000 42.33391 ? 580 HOH A O   1 
HETATM 4742 O O   . HOH E 3 .   ? 4.78473   8.23607   2.32347   1.000 53.52824 ? 581 HOH A O   1 
HETATM 4743 O O   . HOH E 3 .   ? -0.99062  -13.49268 10.47668  1.000 54.23263 ? 582 HOH A O   1 
HETATM 4744 O O   . HOH E 3 .   ? 3.94023   5.77652   3.18414   1.000 57.89128 ? 583 HOH A O   1 
HETATM 4745 O O   . HOH E 3 .   ? -33.48042 -21.45517 10.26873  1.000 45.98494 ? 584 HOH A O   1 
HETATM 4746 O O   . HOH E 3 .   ? -11.03854 -15.41417 14.44315  1.000 52.36875 ? 585 HOH A O   1 
HETATM 4747 O O   . HOH E 3 .   ? -29.71573 -18.69062 -1.67858  1.000 41.61362 ? 586 HOH A O   1 
HETATM 4748 O O   . HOH E 3 .   ? -5.08234  -14.88982 -1.77021  1.000 51.97388 ? 587 HOH A O   1 
HETATM 4749 O O   . HOH E 3 .   ? -22.47940 -27.46639 -7.50218  1.000 52.52533 ? 588 HOH A O   1 
HETATM 4750 O O   . HOH E 3 .   ? -29.10361 -29.23221 -8.58627  1.000 66.72880 ? 589 HOH A O   1 
HETATM 4751 O O   . HOH E 3 .   ? -29.38851 -25.82210 22.07018  1.000 71.43281 ? 590 HOH A O   1 
HETATM 4752 O O   . HOH E 3 .   ? -25.910   -40.175   11.195    1.000 53.59318 ? 591 HOH A O   1 
HETATM 4753 O O   . HOH E 3 .   ? -23.35107 -15.35685 12.63420  1.000 39.49408 ? 592 HOH A O   1 
HETATM 4754 O O   . HOH E 3 .   ? -34.39784 -24.98449 20.35483  1.000 51.38527 ? 593 HOH A O   1 
HETATM 4755 O O   . HOH E 3 .   ? -25.59326 -9.88723  9.88178   1.000 44.81313 ? 594 HOH A O   1 
HETATM 4756 O O   . HOH E 3 .   ? 3.11437   7.32837   0.57452   1.000 48.13808 ? 595 HOH A O   1 
HETATM 4757 O O   . HOH E 3 .   ? 2.95861   18.75293  12.41447  1.000 48.52170 ? 596 HOH A O   1 
HETATM 4758 O O   . HOH E 3 .   ? -0.71433  -4.76119  18.11440  1.000 56.27765 ? 597 HOH A O   1 
HETATM 4759 O O   . HOH E 3 .   ? -20.21481 13.28249  14.88585  1.000 54.97171 ? 598 HOH A O   1 
HETATM 4760 O O   . HOH E 3 .   ? -30.17420 -24.50221 17.58186  1.000 50.11247 ? 599 HOH A O   1 
HETATM 4761 O O   . HOH E 3 .   ? -4.80829  -31.28066 0.86834   1.000 59.70705 ? 600 HOH A O   1 
HETATM 4762 O O   . HOH E 3 .   ? -2.92952  -26.70104 8.44956   1.000 55.80084 ? 601 HOH A O   1 
HETATM 4763 O O   . HOH E 3 .   ? 3.62487   13.16717  -4.84058  1.000 65.31960 ? 602 HOH A O   1 
HETATM 4764 O O   . HOH E 3 .   ? -23.494   -40.215   10.014    1.000 53.73306 ? 603 HOH A O   1 
HETATM 4765 O O   . HOH E 3 .   ? 0.517     -15.950   9.865     1.000 52.12955 ? 604 HOH A O   1 
HETATM 4766 O O   . HOH E 3 .   ? -27.88708 -12.56472 6.21894   1.000 47.17318 ? 605 HOH A O   1 
HETATM 4767 O O   . HOH E 3 .   ? -22.29609 -18.23556 24.10680  1.000 48.83463 ? 606 HOH A O   1 
HETATM 4768 O O   . HOH E 3 .   ? -5.60745  -30.63967 -2.02052  1.000 58.10969 ? 607 HOH A O   1 
HETATM 4769 O O   . HOH E 3 .   ? -20.37743 -25.18631 -6.58216  1.000 51.77568 ? 608 HOH A O   1 
HETATM 4770 O O   . HOH F 3 .   ? -46.98723 5.61988   -9.01026  1.000 53.07840 ? 501 HOH B O   1 
HETATM 4771 O O   . HOH F 3 .   ? -53.43208 -16.89466 -11.20402 1.000 56.31488 ? 502 HOH B O   1 
HETATM 4772 O O   . HOH F 3 .   ? -51.47074 -25.90504 33.29375  1.000 73.10052 ? 503 HOH B O   1 
HETATM 4773 O O   . HOH F 3 .   ? -53.71785 -20.11956 18.67803  1.000 47.64666 ? 504 HOH B O   1 
HETATM 4774 O O   . HOH F 3 .   ? -38.84037 0.95328   -17.93265 1.000 50.37816 ? 505 HOH B O   1 
HETATM 4775 O O   . HOH F 3 .   ? -47.50084 -1.78968  27.28460  1.000 51.20814 ? 506 HOH B O   1 
HETATM 4776 O O   . HOH F 3 .   ? -48.05320 3.80466   -1.70389  1.000 42.72608 ? 507 HOH B O   1 
HETATM 4777 O O   . HOH F 3 .   ? -38.43003 5.27074   15.68205  1.000 54.16070 ? 508 HOH B O   1 
HETATM 4778 O O   . HOH F 3 .   ? -31.86952 8.35895   29.69192  1.000 62.41509 ? 509 HOH B O   1 
HETATM 4779 O O   . HOH F 3 .   ? -34.15736 -5.48097  6.17771   1.000 35.60349 ? 510 HOH B O   1 
HETATM 4780 O O   . HOH F 3 .   ? -52.02469 -2.38747  -0.80511  1.000 34.16094 ? 511 HOH B O   1 
HETATM 4781 O O   . HOH F 3 .   ? -33.78713 -7.80532  23.11939  1.000 46.22943 ? 512 HOH B O   1 
HETATM 4782 O O   . HOH F 3 .   ? -24.81388 -12.62494 -7.45794  1.000 53.57325 ? 513 HOH B O   1 
HETATM 4783 O O   . HOH F 3 .   ? -30.06402 3.27614   8.47104   1.000 49.66087 ? 514 HOH B O   1 
HETATM 4784 O O   . HOH F 3 .   ? -42.47087 0.23177   -19.85226 1.000 61.50569 ? 515 HOH B O   1 
HETATM 4785 O O   . HOH F 3 .   ? -30.39955 -16.76018 19.54903  1.000 42.89310 ? 516 HOH B O   1 
HETATM 4786 O O   . HOH F 3 .   ? -24.54767 0.77416   1.68590   1.000 45.72497 ? 517 HOH B O   1 
HETATM 4787 O O   . HOH F 3 .   ? -46.91816 -24.48919 13.43323  1.000 52.97407 ? 518 HOH B O   1 
HETATM 4788 O O   . HOH F 3 .   ? -40.46107 0.43843   5.39888   1.000 46.98941 ? 519 HOH B O   1 
HETATM 4789 O O   . HOH F 3 .   ? -32.30628 8.12937   22.11741  1.000 52.80592 ? 520 HOH B O   1 
HETATM 4790 O O   . HOH F 3 .   ? -46.32497 -13.47443 15.86654  1.000 38.29197 ? 521 HOH B O   1 
HETATM 4791 O O   . HOH F 3 .   ? -50.66573 -22.30021 -7.91302  1.000 64.27684 ? 522 HOH B O   1 
HETATM 4792 O O   . HOH F 3 .   ? -39.13827 3.43886   -4.05876  1.000 43.70299 ? 523 HOH B O   1 
HETATM 4793 O O   . HOH F 3 .   ? -48.58841 -12.96640 -18.06420 1.000 65.14725 ? 524 HOH B O   1 
HETATM 4794 O O   . HOH F 3 .   ? -45.65433 -2.04024  20.06956  1.000 42.62962 ? 525 HOH B O   1 
HETATM 4795 O O   . HOH F 3 .   ? -29.63845 2.25940   26.10074  1.000 54.11577 ? 526 HOH B O   1 
HETATM 4796 O O   . HOH F 3 .   ? -38.77334 -13.37472 9.11386   1.000 34.46352 ? 527 HOH B O   1 
HETATM 4797 O O   . HOH F 3 .   ? -54.07378 -4.35397  -14.91727 1.000 49.44149 ? 528 HOH B O   1 
HETATM 4798 O O   . HOH F 3 .   ? -36.61803 -8.21417  -0.51699  1.000 34.55894 ? 529 HOH B O   1 
HETATM 4799 O O   . HOH F 3 .   ? -44.36968 4.27244   -8.82958  1.000 46.90153 ? 530 HOH B O   1 
HETATM 4800 O O   . HOH F 3 .   ? -35.82930 -2.57731  9.33878   1.000 35.47980 ? 531 HOH B O   1 
HETATM 4801 O O   . HOH F 3 .   ? -51.78197 -7.39917  -1.47148  1.000 36.47563 ? 532 HOH B O   1 
HETATM 4802 O O   . HOH F 3 .   ? -50.89889 -17.31679 10.50882  1.000 42.94066 ? 533 HOH B O   1 
HETATM 4803 O O   . HOH F 3 .   ? -51.79187 -18.11721 -3.47027  1.000 57.47122 ? 534 HOH B O   1 
HETATM 4804 O O   . HOH F 3 .   ? -43.04083 -4.02152  2.42781   1.000 39.98952 ? 535 HOH B O   1 
HETATM 4805 O O   . HOH F 3 .   ? -54.64418 1.52698   0.68937   1.000 40.48628 ? 536 HOH B O   1 
HETATM 4806 O O   . HOH F 3 .   ? -50.113   5.314     -2.973    1.000 50.56281 ? 537 HOH B O   1 
HETATM 4807 O O   . HOH F 3 .   ? -37.99413 -5.87192  -17.64901 1.000 50.04556 ? 538 HOH B O   1 
HETATM 4808 O O   . HOH F 3 .   ? -38.64108 -15.65709 2.06091   1.000 47.18667 ? 539 HOH B O   1 
HETATM 4809 O O   . HOH F 3 .   ? -40.51773 -20.01995 -9.48223  1.000 48.66838 ? 540 HOH B O   1 
HETATM 4810 O O   . HOH F 3 .   ? -44.46904 -19.44695 8.83546   1.000 49.26219 ? 541 HOH B O   1 
HETATM 4811 O O   . HOH F 3 .   ? -53.87187 -5.01285  -7.75111  1.000 49.04262 ? 542 HOH B O   1 
HETATM 4812 O O   . HOH F 3 .   ? -53.78950 -10.76293 17.90037  1.000 50.54410 ? 543 HOH B O   1 
HETATM 4813 O O   . HOH F 3 .   ? -55.86293 -13.01374 29.83092  1.000 62.14770 ? 544 HOH B O   1 
HETATM 4814 O O   . HOH F 3 .   ? -51.49135 -2.25028  -15.59966 1.000 54.47314 ? 545 HOH B O   1 
HETATM 4815 O O   . HOH F 3 .   ? -49.97769 -5.82675  11.86503  1.000 48.89115 ? 546 HOH B O   1 
HETATM 4816 O O   . HOH F 3 .   ? -31.87582 -20.68061 -8.46281  1.000 59.16296 ? 547 HOH B O   1 
HETATM 4817 O O   . HOH F 3 .   ? -46.12761 -3.87265  4.68528   1.000 39.81075 ? 548 HOH B O   1 
HETATM 4818 O O   . HOH F 3 .   ? -52.83638 -11.46501 21.85353  1.000 41.87556 ? 549 HOH B O   1 
HETATM 4819 O O   . HOH F 3 .   ? -52.88917 -15.23626 24.32798  1.000 46.61333 ? 550 HOH B O   1 
HETATM 4820 O O   . HOH F 3 .   ? -54.35000 -1.75439  -6.73101  1.000 42.22187 ? 551 HOH B O   1 
HETATM 4821 O O   . HOH F 3 .   ? -52.48353 -12.07907 -7.25367  1.000 47.88856 ? 552 HOH B O   1 
HETATM 4822 O O   . HOH F 3 .   ? -48.88932 0.99169   15.88474  1.000 47.45791 ? 553 HOH B O   1 
HETATM 4823 O O   . HOH F 3 .   ? -38.22985 -0.71520  6.54853   1.000 36.33041 ? 554 HOH B O   1 
HETATM 4824 O O   . HOH F 3 .   ? -44.61511 -21.77753 9.41602   1.000 50.58466 ? 555 HOH B O   1 
HETATM 4825 O O   . HOH F 3 .   ? -22.54205 -6.91405  -14.01138 1.000 63.51746 ? 556 HOH B O   1 
HETATM 4826 O O   . HOH F 3 .   ? -29.35618 -10.60659 -1.60052  1.000 46.40711 ? 557 HOH B O   1 
HETATM 4827 O O   . HOH F 3 .   ? -23.40386 -6.82103  -2.70687  1.000 47.52119 ? 558 HOH B O   1 
HETATM 4828 O O   . HOH F 3 .   ? -31.03585 -1.88957  4.58547   1.000 41.17062 ? 559 HOH B O   1 
HETATM 4829 O O   . HOH F 3 .   ? -54.37644 4.20913   -1.32063  1.000 42.43267 ? 560 HOH B O   1 
HETATM 4830 O O   . HOH F 3 .   ? -23.99492 -16.06420 23.40546  1.000 56.45000 ? 561 HOH B O   1 
HETATM 4831 O O   . HOH F 3 .   ? -39.95658 -17.10824 -5.07881  1.000 48.75201 ? 562 HOH B O   1 
HETATM 4832 O O   . HOH F 3 .   ? -40.64513 -0.89211  14.58182  1.000 39.20359 ? 563 HOH B O   1 
HETATM 4833 O O   . HOH F 3 .   ? -49.69034 -0.02261  -12.15166 1.000 47.72170 ? 564 HOH B O   1 
HETATM 4834 O O   . HOH F 3 .   ? -50.33963 -1.54889  12.22570  1.000 48.83441 ? 565 HOH B O   1 
HETATM 4835 O O   . HOH F 3 .   ? -54.93600 -10.84770 38.38155  1.000 47.50019 ? 566 HOH B O   1 
HETATM 4836 O O   . HOH F 3 .   ? -43.12292 2.94149   -12.93441 1.000 49.47562 ? 567 HOH B O   1 
HETATM 4837 O O   . HOH F 3 .   ? -37.23367 -20.92960 27.76994  1.000 51.69974 ? 568 HOH B O   1 
HETATM 4838 O O   . HOH F 3 .   ? -42.33296 5.00211   14.33659  1.000 54.84940 ? 569 HOH B O   1 
HETATM 4839 O O   . HOH F 3 .   ? -46.61581 -7.10297  -2.06493  1.000 36.81038 ? 570 HOH B O   1 
HETATM 4840 O O   . HOH F 3 .   ? -35.19517 8.41608   -6.85817  1.000 50.96257 ? 571 HOH B O   1 
HETATM 4841 O O   . HOH F 3 .   ? -39.79169 -1.67174  8.40042   1.000 37.05469 ? 572 HOH B O   1 
HETATM 4842 O O   . HOH F 3 .   ? -30.15100 -21.39649 25.92947  1.000 60.42010 ? 573 HOH B O   1 
HETATM 4843 O O   . HOH F 3 .   ? -40.39480 -17.30592 -2.36562  1.000 48.55523 ? 574 HOH B O   1 
HETATM 4844 O O   . HOH F 3 .   ? -40.70892 0.55132   2.72558   1.000 36.85975 ? 575 HOH B O   1 
HETATM 4845 O O   . HOH F 3 .   ? -21.03030 3.37406   -3.97614  1.000 46.56747 ? 576 HOH B O   1 
HETATM 4846 O O   . HOH F 3 .   ? -31.25455 -4.52571  5.84411   1.000 38.34819 ? 577 HOH B O   1 
HETATM 4847 O O   . HOH F 3 .   ? -52.67749 -10.13822 13.79190  1.000 43.48326 ? 578 HOH B O   1 
HETATM 4848 O O   . HOH F 3 .   ? -33.76411 -24.16765 22.59066  1.000 53.92943 ? 579 HOH B O   1 
HETATM 4849 O O   . HOH F 3 .   ? -23.16275 -15.67527 -2.81029  1.000 57.75953 ? 580 HOH B O   1 
HETATM 4850 O O   . HOH F 3 .   ? -53.57059 -13.82584 22.03956  1.000 48.75419 ? 581 HOH B O   1 
HETATM 4851 O O   . HOH F 3 .   ? -45.33584 0.85520   -13.95983 1.000 47.85810 ? 582 HOH B O   1 
HETATM 4852 O O   . HOH F 3 .   ? -48.31921 3.58923   -11.81767 1.000 55.61258 ? 583 HOH B O   1 
HETATM 4853 O O   . HOH F 3 .   ? -43.01632 -1.31807  2.36131   1.000 43.77506 ? 584 HOH B O   1 
HETATM 4854 O O   . HOH F 3 .   ? -37.43466 -17.91957 -4.74939  1.000 47.00417 ? 585 HOH B O   1 
HETATM 4855 O O   . HOH F 3 .   ? -28.95871 -20.04522 31.18208  1.000 62.77431 ? 586 HOH B O   1 
HETATM 4856 O O   . HOH F 3 .   ? -29.08646 -7.46564  32.67869  1.000 60.07025 ? 587 HOH B O   1 
HETATM 4857 O O   . HOH F 3 .   ? -47.74970 0.43237   42.97141  1.000 71.63100 ? 588 HOH B O   1 
HETATM 4858 O O   . HOH F 3 .   ? -51.86047 -7.30475  12.94728  1.000 51.50639 ? 589 HOH B O   1 
HETATM 4859 O O   . HOH F 3 .   ? -22.91099 -12.37276 25.67159  1.000 60.75566 ? 590 HOH B O   1 
HETATM 4860 O O   . HOH F 3 .   ? -53.46069 -17.98576 26.63054  1.000 48.23212 ? 591 HOH B O   1 
HETATM 4861 O O   . HOH F 3 .   ? -55.54644 -16.88798 30.69993  1.000 52.56653 ? 592 HOH B O   1 
HETATM 4862 O O   . HOH F 3 .   ? -37.94119 8.55751   26.45815  1.000 50.40838 ? 593 HOH B O   1 
HETATM 4863 O O   . HOH F 3 .   ? -28.23772 6.41956   4.45149   1.000 61.02194 ? 594 HOH B O   1 
HETATM 4864 O O   . HOH F 3 .   ? -60.34896 -16.80781 36.66589  1.000 69.84729 ? 595 HOH B O   1 
HETATM 4865 O O   . HOH F 3 .   ? -39.61566 8.71143   24.79653  1.000 51.67682 ? 596 HOH B O   1 
HETATM 4866 O O   . HOH F 3 .   ? -28.41022 -9.42825  33.75478  1.000 60.09904 ? 597 HOH B O   1 
HETATM 4867 O O   . HOH F 3 .   ? -41.50736 0.17722   9.61656   1.000 47.90070 ? 598 HOH B O   1 
HETATM 4868 O O   . HOH F 3 .   ? -54.76857 -11.59556 -9.04622  1.000 55.87485 ? 599 HOH B O   1 
HETATM 4869 O O   . HOH F 3 .   ? -48.44816 -1.28868  19.84712  1.000 52.99346 ? 600 HOH B O   1 
HETATM 4870 O O   . HOH F 3 .   ? -51.83105 -5.08527  0.16471   1.000 38.70348 ? 601 HOH B O   1 
HETATM 4871 O O   . HOH F 3 .   ? -55.10442 -16.44664 25.64058  1.000 51.51858 ? 602 HOH B O   1 
HETATM 4872 O O   . HOH F 3 .   ? -53.66614 -9.40409  40.05406  1.000 54.96806 ? 603 HOH B O   1 
HETATM 4873 O O   . HOH F 3 .   ? -41.02572 3.32493   2.09336   1.000 48.39465 ? 604 HOH B O   1 
HETATM 4874 O O   . HOH F 3 .   ? -45.71091 -4.41020  2.29727   1.000 46.41275 ? 605 HOH B O   1 
HETATM 4875 O O   . HOH F 3 .   ? -46.01690 5.94738   -1.30454  1.000 42.49230 ? 606 HOH B O   1 
HETATM 4876 O O   . HOH F 3 .   ? -51.37520 -0.49134  -13.83622 1.000 51.89534 ? 607 HOH B O   1 
HETATM 4877 O O   . HOH F 3 .   ? -45.31049 1.09565   -16.80217 1.000 51.68980 ? 608 HOH B O   1 
HETATM 4878 O O   . HOH F 3 .   ? -56.31437 -14.22090 21.90222  1.000 53.60211 ? 609 HOH B O   1 
HETATM 4879 O O   . HOH F 3 .   ? -25.75132 6.49457   4.60400   1.000 56.52051 ? 610 HOH B O   1 
HETATM 4880 O O   . HOH F 3 .   ? -47.43945 1.69194   -13.12978 1.000 50.98552 ? 611 HOH B O   1 
HETATM 4881 O O   . HOH F 3 .   ? -41.12308 -19.43800 -6.81396  1.000 57.96212 ? 612 HOH B O   1 
# 
