data_9BO8
# 
_entry.id   9BO8 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BO8         pdb_00009bo8 10.2210/pdb9bo8/pdb 
WWPDB D_1000283733 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-12 ? 
2 'Structure model' 1 1 2025-03-12 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
_pdbx_audit_revision_category.ordinal             1 
_pdbx_audit_revision_category.revision_ordinal    2 
_pdbx_audit_revision_category.data_content_type   'Structure model' 
_pdbx_audit_revision_category.category            citation 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
5 2 'Structure model' '_citation.title'                   
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BO8 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-03 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              karen.anderson@yale.edu 
_pdbx_contact_author.name_first         Karen 
_pdbx_contact_author.name_last          Anderson 
_pdbx_contact_author.name_mi            S 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-3433-0780 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Papini, C.'     1 0000-0002-6098-4959 
'Anderson, K.S.' 2 0000-0003-3433-0780 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Acs Bio Med Chem Au' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2694-2437 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            5 
_citation.language                  ? 
_citation.page_first                215 
_citation.page_last                 226 
_citation.title                     
'Exploring Possible Drug-Resistant Variants of SARS-CoV-2 Main Protease (M pro ) with Noncovalent Preclinical Candidate, Mpro61.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acsbiomedchemau.4c00109 
_citation.pdbx_database_id_PubMed   39990941 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Kenneson, J.R.'  1 ? 
primary 'Papini, C.'      2 ? 
primary 'Tang, S.'        3 ? 
primary 'Huynh, K.'       4 ? 
primary 'Zhang, C.H.'     5 ? 
primary 'Jorgensen, W.L.' 6 ? 
primary 'Anderson, K.S.'  7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '3C-like proteinase'                                                                                   33837.602 
1   3.4.22.69 ? ? ? 
2 non-polymer syn 'N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide' 405.488   
1   ?         ? ? ? 
3 water       nat water                                                                                                  18.015    
274 ?         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '3CL-PRO, 3CLp, Main protease, Mpro, Non-structural protein 5, nsp5, SARS coronavirus main proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SGFRKMAFPSGKVEGCMVQVICGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SGFRKMAFPSGKVEGCMVQVICGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide' UED 
3 water                                                                                                  HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   GLY n 
1 3   PHE n 
1 4   ARG n 
1 5   LYS n 
1 6   MET n 
1 7   ALA n 
1 8   PHE n 
1 9   PRO n 
1 10  SER n 
1 11  GLY n 
1 12  LYS n 
1 13  VAL n 
1 14  GLU n 
1 15  GLY n 
1 16  CYS n 
1 17  MET n 
1 18  VAL n 
1 19  GLN n 
1 20  VAL n 
1 21  ILE n 
1 22  CYS n 
1 23  GLY n 
1 24  THR n 
1 25  THR n 
1 26  THR n 
1 27  LEU n 
1 28  ASN n 
1 29  GLY n 
1 30  LEU n 
1 31  TRP n 
1 32  LEU n 
1 33  ASP n 
1 34  ASP n 
1 35  VAL n 
1 36  VAL n 
1 37  TYR n 
1 38  CYS n 
1 39  PRO n 
1 40  ARG n 
1 41  HIS n 
1 42  VAL n 
1 43  ILE n 
1 44  CYS n 
1 45  THR n 
1 46  SER n 
1 47  GLU n 
1 48  ASP n 
1 49  MET n 
1 50  LEU n 
1 51  ASN n 
1 52  PRO n 
1 53  ASN n 
1 54  TYR n 
1 55  GLU n 
1 56  ASP n 
1 57  LEU n 
1 58  LEU n 
1 59  ILE n 
1 60  ARG n 
1 61  LYS n 
1 62  SER n 
1 63  ASN n 
1 64  HIS n 
1 65  ASN n 
1 66  PHE n 
1 67  LEU n 
1 68  VAL n 
1 69  GLN n 
1 70  ALA n 
1 71  GLY n 
1 72  ASN n 
1 73  VAL n 
1 74  GLN n 
1 75  LEU n 
1 76  ARG n 
1 77  VAL n 
1 78  ILE n 
1 79  GLY n 
1 80  HIS n 
1 81  SER n 
1 82  MET n 
1 83  GLN n 
1 84  ASN n 
1 85  CYS n 
1 86  VAL n 
1 87  LEU n 
1 88  LYS n 
1 89  LEU n 
1 90  LYS n 
1 91  VAL n 
1 92  ASP n 
1 93  THR n 
1 94  ALA n 
1 95  ASN n 
1 96  PRO n 
1 97  LYS n 
1 98  THR n 
1 99  PRO n 
1 100 LYS n 
1 101 TYR n 
1 102 LYS n 
1 103 PHE n 
1 104 VAL n 
1 105 ARG n 
1 106 ILE n 
1 107 GLN n 
1 108 PRO n 
1 109 GLY n 
1 110 GLN n 
1 111 THR n 
1 112 PHE n 
1 113 SER n 
1 114 VAL n 
1 115 LEU n 
1 116 ALA n 
1 117 CYS n 
1 118 TYR n 
1 119 ASN n 
1 120 GLY n 
1 121 SER n 
1 122 PRO n 
1 123 SER n 
1 124 GLY n 
1 125 VAL n 
1 126 TYR n 
1 127 GLN n 
1 128 CYS n 
1 129 ALA n 
1 130 MET n 
1 131 ARG n 
1 132 PRO n 
1 133 ASN n 
1 134 PHE n 
1 135 THR n 
1 136 ILE n 
1 137 LYS n 
1 138 GLY n 
1 139 SER n 
1 140 PHE n 
1 141 LEU n 
1 142 ASN n 
1 143 GLY n 
1 144 SER n 
1 145 CYS n 
1 146 GLY n 
1 147 SER n 
1 148 VAL n 
1 149 GLY n 
1 150 PHE n 
1 151 ASN n 
1 152 ILE n 
1 153 ASP n 
1 154 TYR n 
1 155 ASP n 
1 156 CYS n 
1 157 VAL n 
1 158 SER n 
1 159 PHE n 
1 160 CYS n 
1 161 TYR n 
1 162 MET n 
1 163 HIS n 
1 164 HIS n 
1 165 MET n 
1 166 GLU n 
1 167 LEU n 
1 168 PRO n 
1 169 THR n 
1 170 GLY n 
1 171 VAL n 
1 172 HIS n 
1 173 ALA n 
1 174 GLY n 
1 175 THR n 
1 176 ASP n 
1 177 LEU n 
1 178 GLU n 
1 179 GLY n 
1 180 ASN n 
1 181 PHE n 
1 182 TYR n 
1 183 GLY n 
1 184 PRO n 
1 185 PHE n 
1 186 VAL n 
1 187 ASP n 
1 188 ARG n 
1 189 GLN n 
1 190 THR n 
1 191 ALA n 
1 192 GLN n 
1 193 ALA n 
1 194 ALA n 
1 195 GLY n 
1 196 THR n 
1 197 ASP n 
1 198 THR n 
1 199 THR n 
1 200 ILE n 
1 201 THR n 
1 202 VAL n 
1 203 ASN n 
1 204 VAL n 
1 205 LEU n 
1 206 ALA n 
1 207 TRP n 
1 208 LEU n 
1 209 TYR n 
1 210 ALA n 
1 211 ALA n 
1 212 VAL n 
1 213 ILE n 
1 214 ASN n 
1 215 GLY n 
1 216 ASP n 
1 217 ARG n 
1 218 TRP n 
1 219 PHE n 
1 220 LEU n 
1 221 ASN n 
1 222 ARG n 
1 223 PHE n 
1 224 THR n 
1 225 THR n 
1 226 THR n 
1 227 LEU n 
1 228 ASN n 
1 229 ASP n 
1 230 PHE n 
1 231 ASN n 
1 232 LEU n 
1 233 VAL n 
1 234 ALA n 
1 235 MET n 
1 236 LYS n 
1 237 TYR n 
1 238 ASN n 
1 239 TYR n 
1 240 GLU n 
1 241 PRO n 
1 242 LEU n 
1 243 THR n 
1 244 GLN n 
1 245 ASP n 
1 246 HIS n 
1 247 VAL n 
1 248 ASP n 
1 249 ILE n 
1 250 LEU n 
1 251 GLY n 
1 252 PRO n 
1 253 LEU n 
1 254 SER n 
1 255 ALA n 
1 256 GLN n 
1 257 THR n 
1 258 GLY n 
1 259 ILE n 
1 260 ALA n 
1 261 VAL n 
1 262 LEU n 
1 263 ASP n 
1 264 MET n 
1 265 CYS n 
1 266 ALA n 
1 267 SER n 
1 268 LEU n 
1 269 LYS n 
1 270 GLU n 
1 271 LEU n 
1 272 LEU n 
1 273 GLN n 
1 274 ASN n 
1 275 GLY n 
1 276 MET n 
1 277 ASN n 
1 278 GLY n 
1 279 ARG n 
1 280 THR n 
1 281 ILE n 
1 282 LEU n 
1 283 GLY n 
1 284 SER n 
1 285 ALA n 
1 286 LEU n 
1 287 LEU n 
1 288 GLU n 
1 289 ASP n 
1 290 GLU n 
1 291 PHE n 
1 292 THR n 
1 293 PRO n 
1 294 PHE n 
1 295 ASP n 
1 296 VAL n 
1 297 VAL n 
1 298 ARG n 
1 299 GLN n 
1 300 CYS n 
1 301 SER n 
1 302 GLY n 
1 303 VAL n 
1 304 THR n 
1 305 PHE n 
1 306 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   306 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                                                                                ? 
'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                                                                               ? 
'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                                                                             ? 
'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                                                                        ? 
'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE                                                                                               ? 
'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE                                                                                              ? 
'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                                                                        ? 
'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                                                                                ? 
'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                                                                                              ? 
'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                                                                                  ? 
'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                                                                             ? 
'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                                                                                ? 
'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                                                                                 ? 
'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                                                                                             ? 
'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE                                                                                          ? 
'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                                                                                                ? 
'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                                                                                 ? 
'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                                                                                              ? 
'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                                                                             ? 
'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                                                                               ? 
'C9 H11 N O3'    181.189 
UED non-polymer         . 'N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide' 
'GC373 bound form, GC376 bound form' 'C21 H31 N3 O5'  405.488 
VAL 'L-peptide linking' y VALINE                                                                                                 ? 
'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   1   1   SER SER A . n 
A 1 2   GLY 2   2   2   GLY GLY A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   ARG 4   4   4   ARG ARG A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   MET 6   6   6   MET MET A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   PRO 9   9   9   PRO PRO A . n 
A 1 10  SER 10  10  10  SER SER A . n 
A 1 11  GLY 11  11  11  GLY GLY A . n 
A 1 12  LYS 12  12  12  LYS LYS A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  GLY 15  15  15  GLY GLY A . n 
A 1 16  CYS 16  16  16  CYS CYS A . n 
A 1 17  MET 17  17  17  MET MET A . n 
A 1 18  VAL 18  18  18  VAL VAL A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  ILE 21  21  21  ILE ILE A . n 
A 1 22  CYS 22  22  22  CYS CYS A . n 
A 1 23  GLY 23  23  23  GLY GLY A . n 
A 1 24  THR 24  24  24  THR THR A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  THR 26  26  26  THR THR A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  ASN 28  28  28  ASN ASN A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  TRP 31  31  31  TRP TRP A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  ASP 33  33  33  ASP ASP A . n 
A 1 34  ASP 34  34  34  ASP ASP A . n 
A 1 35  VAL 35  35  35  VAL VAL A . n 
A 1 36  VAL 36  36  36  VAL VAL A . n 
A 1 37  TYR 37  37  37  TYR TYR A . n 
A 1 38  CYS 38  38  38  CYS CYS A . n 
A 1 39  PRO 39  39  39  PRO PRO A . n 
A 1 40  ARG 40  40  40  ARG ARG A . n 
A 1 41  HIS 41  41  41  HIS HIS A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  ILE 43  43  43  ILE ILE A . n 
A 1 44  CYS 44  44  44  CYS CYS A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  SER 46  46  46  SER SER A . n 
A 1 47  GLU 47  47  47  GLU GLU A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  MET 49  49  49  MET MET A . n 
A 1 50  LEU 50  50  50  LEU LEU A . n 
A 1 51  ASN 51  51  51  ASN ASN A . n 
A 1 52  PRO 52  52  52  PRO PRO A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  TYR 54  54  54  TYR TYR A . n 
A 1 55  GLU 55  55  55  GLU GLU A . n 
A 1 56  ASP 56  56  56  ASP ASP A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  ILE 59  59  59  ILE ILE A . n 
A 1 60  ARG 60  60  60  ARG ARG A . n 
A 1 61  LYS 61  61  61  LYS LYS A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  ASN 63  63  63  ASN ASN A . n 
A 1 64  HIS 64  64  64  HIS HIS A . n 
A 1 65  ASN 65  65  65  ASN ASN A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  GLN 69  69  69  GLN GLN A . n 
A 1 70  ALA 70  70  70  ALA ALA A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  ASN 72  72  72  ASN ASN A . n 
A 1 73  VAL 73  73  73  VAL VAL A . n 
A 1 74  GLN 74  74  74  GLN GLN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  ARG 76  76  76  ARG ARG A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  GLY 79  79  79  GLY GLY A . n 
A 1 80  HIS 80  80  80  HIS HIS A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  MET 82  82  82  MET MET A . n 
A 1 83  GLN 83  83  83  GLN GLN A . n 
A 1 84  ASN 84  84  84  ASN ASN A . n 
A 1 85  CYS 85  85  85  CYS CYS A . n 
A 1 86  VAL 86  86  86  VAL VAL A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  LYS 88  88  88  LYS LYS A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  LYS 90  90  90  LYS LYS A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  ASP 92  92  92  ASP ASP A . n 
A 1 93  THR 93  93  93  THR THR A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  PRO 96  96  96  PRO PRO A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  PRO 99  99  99  PRO PRO A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 TYR 101 101 101 TYR TYR A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 PHE 103 103 103 PHE PHE A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 ARG 105 105 105 ARG ARG A . n 
A 1 106 ILE 106 106 106 ILE ILE A . n 
A 1 107 GLN 107 107 107 GLN GLN A . n 
A 1 108 PRO 108 108 108 PRO PRO A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 GLN 110 110 110 GLN GLN A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 PHE 112 112 112 PHE PHE A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 CYS 117 117 117 CYS CYS A . n 
A 1 118 TYR 118 118 118 TYR TYR A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 SER 123 123 123 SER SER A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 MET 130 130 130 MET MET A . n 
A 1 131 ARG 131 131 131 ARG ARG A . n 
A 1 132 PRO 132 132 132 PRO PRO A . n 
A 1 133 ASN 133 133 133 ASN ASN A . n 
A 1 134 PHE 134 134 134 PHE PHE A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 LYS 137 137 137 LYS LYS A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 PHE 140 140 140 PHE PHE A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 ASN 142 142 142 ASN ASN A . n 
A 1 143 GLY 143 143 143 GLY GLY A . n 
A 1 144 SER 144 144 144 SER SER A . n 
A 1 145 CYS 145 145 145 CYS CYS A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 GLY 149 149 149 GLY GLY A . n 
A 1 150 PHE 150 150 150 PHE PHE A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 ILE 152 152 152 ILE ILE A . n 
A 1 153 ASP 153 153 153 ASP ASP A . n 
A 1 154 TYR 154 154 154 TYR TYR A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 CYS 156 156 156 CYS CYS A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 SER 158 158 158 SER SER A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 CYS 160 160 160 CYS CYS A . n 
A 1 161 TYR 161 161 161 TYR TYR A . n 
A 1 162 MET 162 162 162 MET MET A . n 
A 1 163 HIS 163 163 163 HIS HIS A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 MET 165 165 165 MET MET A . n 
A 1 166 GLU 166 166 166 GLU GLU A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 PRO 168 168 168 PRO PRO A . n 
A 1 169 THR 169 169 169 THR THR A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 VAL 171 171 171 VAL VAL A . n 
A 1 172 HIS 172 172 172 HIS HIS A . n 
A 1 173 ALA 173 173 173 ALA ALA A . n 
A 1 174 GLY 174 174 174 GLY GLY A . n 
A 1 175 THR 175 175 175 THR THR A . n 
A 1 176 ASP 176 176 176 ASP ASP A . n 
A 1 177 LEU 177 177 177 LEU LEU A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 TYR 182 182 182 TYR TYR A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 VAL 186 186 186 VAL VAL A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 GLN 189 189 189 GLN GLN A . n 
A 1 190 THR 190 190 190 THR THR A . n 
A 1 191 ALA 191 191 191 ALA ALA A . n 
A 1 192 GLN 192 192 192 GLN GLN A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 THR 196 196 196 THR THR A . n 
A 1 197 ASP 197 197 197 ASP ASP A . n 
A 1 198 THR 198 198 198 THR THR A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 ILE 200 200 200 ILE ILE A . n 
A 1 201 THR 201 201 201 THR THR A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 ALA 206 206 206 ALA ALA A . n 
A 1 207 TRP 207 207 207 TRP TRP A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ALA 210 210 210 ALA ALA A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ASN 214 214 214 ASN ASN A . n 
A 1 215 GLY 215 215 215 GLY GLY A . n 
A 1 216 ASP 216 216 216 ASP ASP A . n 
A 1 217 ARG 217 217 217 ARG ARG A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 ASN 221 221 221 ASN ASN A . n 
A 1 222 ARG 222 222 222 ARG ARG A . n 
A 1 223 PHE 223 223 223 PHE PHE A . n 
A 1 224 THR 224 224 224 THR THR A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 THR 226 226 226 THR THR A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 ASN 228 228 228 ASN ASN A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 PHE 230 230 230 PHE PHE A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 VAL 233 233 233 VAL VAL A . n 
A 1 234 ALA 234 234 234 ALA ALA A . n 
A 1 235 MET 235 235 235 MET MET A . n 
A 1 236 LYS 236 236 236 LYS LYS A . n 
A 1 237 TYR 237 237 237 TYR TYR A . n 
A 1 238 ASN 238 238 238 ASN ASN A . n 
A 1 239 TYR 239 239 239 TYR TYR A . n 
A 1 240 GLU 240 240 240 GLU GLU A . n 
A 1 241 PRO 241 241 241 PRO PRO A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 THR 243 243 243 THR THR A . n 
A 1 244 GLN 244 244 244 GLN GLN A . n 
A 1 245 ASP 245 245 245 ASP ASP A . n 
A 1 246 HIS 246 246 246 HIS HIS A . n 
A 1 247 VAL 247 247 247 VAL VAL A . n 
A 1 248 ASP 248 248 248 ASP ASP A . n 
A 1 249 ILE 249 249 249 ILE ILE A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 PRO 252 252 252 PRO PRO A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 SER 254 254 254 SER SER A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 THR 257 257 257 THR THR A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 ILE 259 259 259 ILE ILE A . n 
A 1 260 ALA 260 260 260 ALA ALA A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 LEU 262 262 262 LEU LEU A . n 
A 1 263 ASP 263 263 263 ASP ASP A . n 
A 1 264 MET 264 264 264 MET MET A . n 
A 1 265 CYS 265 265 265 CYS CYS A . n 
A 1 266 ALA 266 266 266 ALA ALA A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 LYS 269 269 269 LYS LYS A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 LEU 271 271 271 LEU LEU A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 ASN 274 274 274 ASN ASN A . n 
A 1 275 GLY 275 275 275 GLY GLY A . n 
A 1 276 MET 276 276 276 MET MET A . n 
A 1 277 ASN 277 277 277 ASN ASN A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 ARG 279 279 279 ARG ARG A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 ILE 281 281 281 ILE ILE A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 GLY 283 283 283 GLY GLY A . n 
A 1 284 SER 284 284 284 SER SER A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 LEU 286 286 286 LEU LEU A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 ASP 289 289 289 ASP ASP A . n 
A 1 290 GLU 290 290 290 GLU GLU A . n 
A 1 291 PHE 291 291 291 PHE PHE A . n 
A 1 292 THR 292 292 292 THR THR A . n 
A 1 293 PRO 293 293 293 PRO PRO A . n 
A 1 294 PHE 294 294 294 PHE PHE A . n 
A 1 295 ASP 295 295 295 ASP ASP A . n 
A 1 296 VAL 296 296 296 VAL VAL A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 GLN 299 299 299 GLN GLN A . n 
A 1 300 CYS 300 300 300 CYS CYS A . n 
A 1 301 SER 301 301 ?   ?   ?   A . n 
A 1 302 GLY 302 302 ?   ?   ?   A . n 
A 1 303 VAL 303 303 ?   ?   ?   A . n 
A 1 304 THR 304 304 ?   ?   ?   A . n 
A 1 305 PHE 305 305 ?   ?   ?   A . n 
A 1 306 GLN 306 306 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        UED 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   UED 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 UED 1   401 999 UED GCA A . 
C 3 HOH 1   501 265 HOH HOH A . 
C 3 HOH 2   502 167 HOH HOH A . 
C 3 HOH 3   503 236 HOH HOH A . 
C 3 HOH 4   504 166 HOH HOH A . 
C 3 HOH 5   505 219 HOH HOH A . 
C 3 HOH 6   506 207 HOH HOH A . 
C 3 HOH 7   507 41  HOH HOH A . 
C 3 HOH 8   508 150 HOH HOH A . 
C 3 HOH 9   509 171 HOH HOH A . 
C 3 HOH 10  510 261 HOH HOH A . 
C 3 HOH 11  511 99  HOH HOH A . 
C 3 HOH 12  512 164 HOH HOH A . 
C 3 HOH 13  513 141 HOH HOH A . 
C 3 HOH 14  514 118 HOH HOH A . 
C 3 HOH 15  515 176 HOH HOH A . 
C 3 HOH 16  516 205 HOH HOH A . 
C 3 HOH 17  517 52  HOH HOH A . 
C 3 HOH 18  518 135 HOH HOH A . 
C 3 HOH 19  519 230 HOH HOH A . 
C 3 HOH 20  520 283 HOH HOH A . 
C 3 HOH 21  521 137 HOH HOH A . 
C 3 HOH 22  522 55  HOH HOH A . 
C 3 HOH 23  523 89  HOH HOH A . 
C 3 HOH 24  524 254 HOH HOH A . 
C 3 HOH 25  525 273 HOH HOH A . 
C 3 HOH 26  526 187 HOH HOH A . 
C 3 HOH 27  527 21  HOH HOH A . 
C 3 HOH 28  528 256 HOH HOH A . 
C 3 HOH 29  529 115 HOH HOH A . 
C 3 HOH 30  530 143 HOH HOH A . 
C 3 HOH 31  531 218 HOH HOH A . 
C 3 HOH 32  532 29  HOH HOH A . 
C 3 HOH 33  533 281 HOH HOH A . 
C 3 HOH 34  534 247 HOH HOH A . 
C 3 HOH 35  535 142 HOH HOH A . 
C 3 HOH 36  536 62  HOH HOH A . 
C 3 HOH 37  537 282 HOH HOH A . 
C 3 HOH 38  538 35  HOH HOH A . 
C 3 HOH 39  539 28  HOH HOH A . 
C 3 HOH 40  540 80  HOH HOH A . 
C 3 HOH 41  541 15  HOH HOH A . 
C 3 HOH 42  542 191 HOH HOH A . 
C 3 HOH 43  543 94  HOH HOH A . 
C 3 HOH 44  544 92  HOH HOH A . 
C 3 HOH 45  545 33  HOH HOH A . 
C 3 HOH 46  546 280 HOH HOH A . 
C 3 HOH 47  547 108 HOH HOH A . 
C 3 HOH 48  548 13  HOH HOH A . 
C 3 HOH 49  549 109 HOH HOH A . 
C 3 HOH 50  550 284 HOH HOH A . 
C 3 HOH 51  551 97  HOH HOH A . 
C 3 HOH 52  552 18  HOH HOH A . 
C 3 HOH 53  553 60  HOH HOH A . 
C 3 HOH 54  554 175 HOH HOH A . 
C 3 HOH 55  555 217 HOH HOH A . 
C 3 HOH 56  556 26  HOH HOH A . 
C 3 HOH 57  557 149 HOH HOH A . 
C 3 HOH 58  558 100 HOH HOH A . 
C 3 HOH 59  559 114 HOH HOH A . 
C 3 HOH 60  560 113 HOH HOH A . 
C 3 HOH 61  561 98  HOH HOH A . 
C 3 HOH 62  562 88  HOH HOH A . 
C 3 HOH 63  563 194 HOH HOH A . 
C 3 HOH 64  564 37  HOH HOH A . 
C 3 HOH 65  565 186 HOH HOH A . 
C 3 HOH 66  566 122 HOH HOH A . 
C 3 HOH 67  567 246 HOH HOH A . 
C 3 HOH 68  568 242 HOH HOH A . 
C 3 HOH 69  569 134 HOH HOH A . 
C 3 HOH 70  570 16  HOH HOH A . 
C 3 HOH 71  571 119 HOH HOH A . 
C 3 HOH 72  572 104 HOH HOH A . 
C 3 HOH 73  573 196 HOH HOH A . 
C 3 HOH 74  574 54  HOH HOH A . 
C 3 HOH 75  575 112 HOH HOH A . 
C 3 HOH 76  576 1   HOH HOH A . 
C 3 HOH 77  577 147 HOH HOH A . 
C 3 HOH 78  578 151 HOH HOH A . 
C 3 HOH 79  579 61  HOH HOH A . 
C 3 HOH 80  580 81  HOH HOH A . 
C 3 HOH 81  581 10  HOH HOH A . 
C 3 HOH 82  582 65  HOH HOH A . 
C 3 HOH 83  583 126 HOH HOH A . 
C 3 HOH 84  584 34  HOH HOH A . 
C 3 HOH 85  585 206 HOH HOH A . 
C 3 HOH 86  586 48  HOH HOH A . 
C 3 HOH 87  587 82  HOH HOH A . 
C 3 HOH 88  588 95  HOH HOH A . 
C 3 HOH 89  589 49  HOH HOH A . 
C 3 HOH 90  590 71  HOH HOH A . 
C 3 HOH 91  591 101 HOH HOH A . 
C 3 HOH 92  592 67  HOH HOH A . 
C 3 HOH 93  593 170 HOH HOH A . 
C 3 HOH 94  594 130 HOH HOH A . 
C 3 HOH 95  595 4   HOH HOH A . 
C 3 HOH 96  596 155 HOH HOH A . 
C 3 HOH 97  597 201 HOH HOH A . 
C 3 HOH 98  598 50  HOH HOH A . 
C 3 HOH 99  599 188 HOH HOH A . 
C 3 HOH 100 600 20  HOH HOH A . 
C 3 HOH 101 601 183 HOH HOH A . 
C 3 HOH 102 602 278 HOH HOH A . 
C 3 HOH 103 603 144 HOH HOH A . 
C 3 HOH 104 604 125 HOH HOH A . 
C 3 HOH 105 605 179 HOH HOH A . 
C 3 HOH 106 606 5   HOH HOH A . 
C 3 HOH 107 607 68  HOH HOH A . 
C 3 HOH 108 608 56  HOH HOH A . 
C 3 HOH 109 609 133 HOH HOH A . 
C 3 HOH 110 610 87  HOH HOH A . 
C 3 HOH 111 611 85  HOH HOH A . 
C 3 HOH 112 612 105 HOH HOH A . 
C 3 HOH 113 613 14  HOH HOH A . 
C 3 HOH 114 614 269 HOH HOH A . 
C 3 HOH 115 615 140 HOH HOH A . 
C 3 HOH 116 616 84  HOH HOH A . 
C 3 HOH 117 617 27  HOH HOH A . 
C 3 HOH 118 618 75  HOH HOH A . 
C 3 HOH 119 619 70  HOH HOH A . 
C 3 HOH 120 620 69  HOH HOH A . 
C 3 HOH 121 621 178 HOH HOH A . 
C 3 HOH 122 622 12  HOH HOH A . 
C 3 HOH 123 623 107 HOH HOH A . 
C 3 HOH 124 624 74  HOH HOH A . 
C 3 HOH 125 625 138 HOH HOH A . 
C 3 HOH 126 626 31  HOH HOH A . 
C 3 HOH 127 627 8   HOH HOH A . 
C 3 HOH 128 628 17  HOH HOH A . 
C 3 HOH 129 629 22  HOH HOH A . 
C 3 HOH 130 630 190 HOH HOH A . 
C 3 HOH 131 631 19  HOH HOH A . 
C 3 HOH 132 632 46  HOH HOH A . 
C 3 HOH 133 633 174 HOH HOH A . 
C 3 HOH 134 634 77  HOH HOH A . 
C 3 HOH 135 635 2   HOH HOH A . 
C 3 HOH 136 636 42  HOH HOH A . 
C 3 HOH 137 637 229 HOH HOH A . 
C 3 HOH 138 638 185 HOH HOH A . 
C 3 HOH 139 639 216 HOH HOH A . 
C 3 HOH 140 640 177 HOH HOH A . 
C 3 HOH 141 641 40  HOH HOH A . 
C 3 HOH 142 642 123 HOH HOH A . 
C 3 HOH 143 643 111 HOH HOH A . 
C 3 HOH 144 644 32  HOH HOH A . 
C 3 HOH 145 645 64  HOH HOH A . 
C 3 HOH 146 646 6   HOH HOH A . 
C 3 HOH 147 647 110 HOH HOH A . 
C 3 HOH 148 648 197 HOH HOH A . 
C 3 HOH 149 649 23  HOH HOH A . 
C 3 HOH 150 650 152 HOH HOH A . 
C 3 HOH 151 651 233 HOH HOH A . 
C 3 HOH 152 652 66  HOH HOH A . 
C 3 HOH 153 653 51  HOH HOH A . 
C 3 HOH 154 654 45  HOH HOH A . 
C 3 HOH 155 655 180 HOH HOH A . 
C 3 HOH 156 656 189 HOH HOH A . 
C 3 HOH 157 657 47  HOH HOH A . 
C 3 HOH 158 658 271 HOH HOH A . 
C 3 HOH 159 659 9   HOH HOH A . 
C 3 HOH 160 660 209 HOH HOH A . 
C 3 HOH 161 661 53  HOH HOH A . 
C 3 HOH 162 662 57  HOH HOH A . 
C 3 HOH 163 663 30  HOH HOH A . 
C 3 HOH 164 664 116 HOH HOH A . 
C 3 HOH 165 665 59  HOH HOH A . 
C 3 HOH 166 666 121 HOH HOH A . 
C 3 HOH 167 667 129 HOH HOH A . 
C 3 HOH 168 668 131 HOH HOH A . 
C 3 HOH 169 669 25  HOH HOH A . 
C 3 HOH 170 670 58  HOH HOH A . 
C 3 HOH 171 671 38  HOH HOH A . 
C 3 HOH 172 672 117 HOH HOH A . 
C 3 HOH 173 673 79  HOH HOH A . 
C 3 HOH 174 674 136 HOH HOH A . 
C 3 HOH 175 675 39  HOH HOH A . 
C 3 HOH 176 676 270 HOH HOH A . 
C 3 HOH 177 677 44  HOH HOH A . 
C 3 HOH 178 678 11  HOH HOH A . 
C 3 HOH 179 679 199 HOH HOH A . 
C 3 HOH 180 680 204 HOH HOH A . 
C 3 HOH 181 681 259 HOH HOH A . 
C 3 HOH 182 682 132 HOH HOH A . 
C 3 HOH 183 683 102 HOH HOH A . 
C 3 HOH 184 684 253 HOH HOH A . 
C 3 HOH 185 685 43  HOH HOH A . 
C 3 HOH 186 686 165 HOH HOH A . 
C 3 HOH 187 687 7   HOH HOH A . 
C 3 HOH 188 688 78  HOH HOH A . 
C 3 HOH 189 689 146 HOH HOH A . 
C 3 HOH 190 690 24  HOH HOH A . 
C 3 HOH 191 691 127 HOH HOH A . 
C 3 HOH 192 692 148 HOH HOH A . 
C 3 HOH 193 693 124 HOH HOH A . 
C 3 HOH 194 694 212 HOH HOH A . 
C 3 HOH 195 695 154 HOH HOH A . 
C 3 HOH 196 696 3   HOH HOH A . 
C 3 HOH 197 697 244 HOH HOH A . 
C 3 HOH 198 698 275 HOH HOH A . 
C 3 HOH 199 699 128 HOH HOH A . 
C 3 HOH 200 700 231 HOH HOH A . 
C 3 HOH 201 701 226 HOH HOH A . 
C 3 HOH 202 702 238 HOH HOH A . 
C 3 HOH 203 703 279 HOH HOH A . 
C 3 HOH 204 704 36  HOH HOH A . 
C 3 HOH 205 705 203 HOH HOH A . 
C 3 HOH 206 706 195 HOH HOH A . 
C 3 HOH 207 707 237 HOH HOH A . 
C 3 HOH 208 708 169 HOH HOH A . 
C 3 HOH 209 709 227 HOH HOH A . 
C 3 HOH 210 710 222 HOH HOH A . 
C 3 HOH 211 711 145 HOH HOH A . 
C 3 HOH 212 712 260 HOH HOH A . 
C 3 HOH 213 713 202 HOH HOH A . 
C 3 HOH 214 714 252 HOH HOH A . 
C 3 HOH 215 715 240 HOH HOH A . 
C 3 HOH 216 716 184 HOH HOH A . 
C 3 HOH 217 717 250 HOH HOH A . 
C 3 HOH 218 718 232 HOH HOH A . 
C 3 HOH 219 719 182 HOH HOH A . 
C 3 HOH 220 720 158 HOH HOH A . 
C 3 HOH 221 721 160 HOH HOH A . 
C 3 HOH 222 722 223 HOH HOH A . 
C 3 HOH 223 723 221 HOH HOH A . 
C 3 HOH 224 724 208 HOH HOH A . 
C 3 HOH 225 725 264 HOH HOH A . 
C 3 HOH 226 726 277 HOH HOH A . 
C 3 HOH 227 727 224 HOH HOH A . 
C 3 HOH 228 728 214 HOH HOH A . 
C 3 HOH 229 729 73  HOH HOH A . 
C 3 HOH 230 730 210 HOH HOH A . 
C 3 HOH 231 731 76  HOH HOH A . 
C 3 HOH 232 732 285 HOH HOH A . 
C 3 HOH 233 733 120 HOH HOH A . 
C 3 HOH 234 734 272 HOH HOH A . 
C 3 HOH 235 735 251 HOH HOH A . 
C 3 HOH 236 736 93  HOH HOH A . 
C 3 HOH 237 737 72  HOH HOH A . 
C 3 HOH 238 738 241 HOH HOH A . 
C 3 HOH 239 739 91  HOH HOH A . 
C 3 HOH 240 740 200 HOH HOH A . 
C 3 HOH 241 741 86  HOH HOH A . 
C 3 HOH 242 742 234 HOH HOH A . 
C 3 HOH 243 743 248 HOH HOH A . 
C 3 HOH 244 744 225 HOH HOH A . 
C 3 HOH 245 745 257 HOH HOH A . 
C 3 HOH 246 746 161 HOH HOH A . 
C 3 HOH 247 747 258 HOH HOH A . 
C 3 HOH 248 748 235 HOH HOH A . 
C 3 HOH 249 749 228 HOH HOH A . 
C 3 HOH 250 750 255 HOH HOH A . 
C 3 HOH 251 751 139 HOH HOH A . 
C 3 HOH 252 752 198 HOH HOH A . 
C 3 HOH 253 753 159 HOH HOH A . 
C 3 HOH 254 754 249 HOH HOH A . 
C 3 HOH 255 755 103 HOH HOH A . 
C 3 HOH 256 756 156 HOH HOH A . 
C 3 HOH 257 757 106 HOH HOH A . 
C 3 HOH 258 758 274 HOH HOH A . 
C 3 HOH 259 759 173 HOH HOH A . 
C 3 HOH 260 760 63  HOH HOH A . 
C 3 HOH 261 761 162 HOH HOH A . 
C 3 HOH 262 762 172 HOH HOH A . 
C 3 HOH 263 763 220 HOH HOH A . 
C 3 HOH 264 764 157 HOH HOH A . 
C 3 HOH 265 765 181 HOH HOH A . 
C 3 HOH 266 766 193 HOH HOH A . 
C 3 HOH 267 767 153 HOH HOH A . 
C 3 HOH 268 768 192 HOH HOH A . 
C 3 HOH 269 769 215 HOH HOH A . 
C 3 HOH 270 770 90  HOH HOH A . 
C 3 HOH 271 771 163 HOH HOH A . 
C 3 HOH 272 772 96  HOH HOH A . 
C 3 HOH 273 773 276 HOH HOH A . 
C 3 HOH 274 774 267 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A SER 46  ? OG  ? A SER 46  OG  
2  1 Y 1 A GLU 47  ? CG  ? A GLU 47  CG  
3  1 Y 1 A GLU 47  ? CD  ? A GLU 47  CD  
4  1 Y 1 A GLU 47  ? OE1 ? A GLU 47  OE1 
5  1 Y 1 A GLU 47  ? OE2 ? A GLU 47  OE2 
6  1 Y 1 A MET 49  ? CG  ? A MET 49  CG  
7  1 Y 1 A MET 49  ? SD  ? A MET 49  SD  
8  1 Y 1 A MET 49  ? CE  ? A MET 49  CE  
9  1 Y 1 A LEU 50  ? CG  ? A LEU 50  CG  
10 1 Y 1 A LEU 50  ? CD1 ? A LEU 50  CD1 
11 1 Y 1 A LEU 50  ? CD2 ? A LEU 50  CD2 
12 1 Y 1 A ASN 51  ? CG  ? A ASN 51  CG  
13 1 Y 1 A ASN 51  ? OD1 ? A ASN 51  OD1 
14 1 Y 1 A ASN 51  ? ND2 ? A ASN 51  ND2 
15 1 Y 1 A ASN 72  ? CG  ? A ASN 72  CG  
16 1 Y 1 A ASN 72  ? OD1 ? A ASN 72  OD1 
17 1 Y 1 A ASN 72  ? ND2 ? A ASN 72  ND2 
18 1 Y 1 A ASP 153 ? CG  ? A ASP 153 CG  
19 1 Y 1 A ASP 153 ? OD1 ? A ASP 153 OD1 
20 1 Y 1 A ASP 153 ? OD2 ? A ASP 153 OD2 
21 1 Y 1 A TYR 154 ? CG  ? A TYR 154 CG  
22 1 Y 1 A TYR 154 ? CD1 ? A TYR 154 CD1 
23 1 Y 1 A TYR 154 ? CD2 ? A TYR 154 CD2 
24 1 Y 1 A TYR 154 ? CE1 ? A TYR 154 CE1 
25 1 Y 1 A TYR 154 ? CE2 ? A TYR 154 CE2 
26 1 Y 1 A TYR 154 ? CZ  ? A TYR 154 CZ  
27 1 Y 1 A TYR 154 ? OH  ? A TYR 154 OH  
28 1 Y 1 A PHE 223 ? CG  ? A PHE 223 CG  
29 1 Y 1 A PHE 223 ? CD1 ? A PHE 223 CD1 
30 1 Y 1 A PHE 223 ? CD2 ? A PHE 223 CD2 
31 1 Y 1 A PHE 223 ? CE1 ? A PHE 223 CE1 
32 1 Y 1 A PHE 223 ? CE2 ? A PHE 223 CE2 
33 1 Y 1 A PHE 223 ? CZ  ? A PHE 223 CZ  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   114.429 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BO8 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     99.172 
_cell.length_a_esd                 ? 
_cell.length_b                     80.598 
_cell.length_b_esd                 ? 
_cell.length_c                     51.859 
_cell.length_c_esd                 ? 
_cell.volume                       377402.906 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BO8 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y' 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BO8 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.79 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          55.89 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M BIS-TRIS, 16% w/v Polyethylene glycol 10,000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            294 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-02-23 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.920105 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSLS-II BEAMLINE 17-ID-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.920105 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   17-ID-1 
_diffrn_source.pdbx_synchrotron_site       NSLS-II 
# 
_reflns.B_iso_Wilson_estimate                          19.39 
_reflns.entry_id                                       9BO8 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.49 
_reflns.d_resolution_low                               30.06 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     59162 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           96.84 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                4.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          8.56 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.996 
_reflns.pdbx_CC_star                                   0.999 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.09103 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.49 
_reflns_shell.d_res_low                                     1.544 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           0.80 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             5288 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               3.7 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.421 
_reflns_shell.pdbx_CC_star                                  0.77 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          88.06 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.505 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               27.56 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9BO8 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.49 
_refine.ls_d_res_low                             30.06 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     58589 
_refine.ls_number_reflns_R_free                  2888 
_refine.ls_number_reflns_R_work                  55701 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    96.86 
_refine.ls_percent_reflns_R_free                 4.93 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1785 
_refine.ls_R_factor_R_free                       0.2022 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1773 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.36 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 23.9089 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2162 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.49 
_refine_hist.d_res_low                        30.06 
_refine_hist.number_atoms_solvent             274 
_refine_hist.number_atoms_total               2594 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2291 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         29 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0118  ? 2415 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.0453  ? 3294 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0878  ? 373  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0085  ? 430  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 13.1152 ? 870  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.49 1.51  . . 118 2227 81.62  . . . . 0.3324 . . . . . . . . . . . 0.3707 
'X-RAY DIFFRACTION' 1.51 1.54  . . 113 2565 94.06  . . . . 0.3328 . . . . . . . . . . . 0.3714 
'X-RAY DIFFRACTION' 1.54 1.57  . . 138 2658 97.46  . . . . 0.3086 . . . . . . . . . . . 0.3238 
'X-RAY DIFFRACTION' 1.57 1.60  . . 127 2734 99.48  . . . . 0.2888 . . . . . . . . . . . 0.3173 
'X-RAY DIFFRACTION' 1.60 1.63  . . 133 2707 99.93  . . . . 0.2778 . . . . . . . . . . . 0.3312 
'X-RAY DIFFRACTION' 1.63 1.67  . . 138 2745 100.00 . . . . 0.2661 . . . . . . . . . . . 0.2994 
'X-RAY DIFFRACTION' 1.67 1.71  . . 151 2709 99.93  . . . . 0.2398 . . . . . . . . . . . 0.2730 
'X-RAY DIFFRACTION' 1.71 1.75  . . 157 2740 99.90  . . . . 0.2192 . . . . . . . . . . . 0.2594 
'X-RAY DIFFRACTION' 1.75 1.80  . . 145 2712 100.00 . . . . 0.2141 . . . . . . . . . . . 0.2137 
'X-RAY DIFFRACTION' 1.80 1.85  . . 138 2748 100.00 . . . . 0.1976 . . . . . . . . . . . 0.2346 
'X-RAY DIFFRACTION' 1.85 1.91  . . 85  1710 63.09  . . . . 0.2025 . . . . . . . . . . . 0.2323 
'X-RAY DIFFRACTION' 1.91 1.98  . . 147 2728 99.65  . . . . 0.1929 . . . . . . . . . . . 0.2449 
'X-RAY DIFFRACTION' 1.98 2.06  . . 165 2742 100.00 . . . . 0.1907 . . . . . . . . . . . 0.2332 
'X-RAY DIFFRACTION' 2.06 2.15  . . 146 2695 99.89  . . . . 0.1720 . . . . . . . . . . . 0.1898 
'X-RAY DIFFRACTION' 2.15 2.26  . . 144 2733 99.65  . . . . 0.1704 . . . . . . . . . . . 0.2285 
'X-RAY DIFFRACTION' 2.26 2.40  . . 142 2733 99.97  . . . . 0.1656 . . . . . . . . . . . 0.1893 
'X-RAY DIFFRACTION' 2.40 2.59  . . 140 2763 99.90  . . . . 0.1682 . . . . . . . . . . . 0.1870 
'X-RAY DIFFRACTION' 2.59 2.85  . . 144 2731 99.76  . . . . 0.1689 . . . . . . . . . . . 0.2031 
'X-RAY DIFFRACTION' 2.85 3.26  . . 132 2757 99.76  . . . . 0.1597 . . . . . . . . . . . 0.1894 
'X-RAY DIFFRACTION' 3.26 4.11  . . 136 2758 99.76  . . . . 0.1455 . . . . . . . . . . . 0.1591 
'X-RAY DIFFRACTION' 4.11 30.06 . . 149 2806 99.83  . . . . 0.1478 . . . . . . . . . . . 0.1556 
# 
_struct.entry_id                     9BO8 
_struct.title                        'Crystal Structure of T21I SARS-CoV-2 Main Protease in Complex with GC376' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BO8 
_struct_keywords.text            'Hydrolase, VIRAL PROTEIN' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1A_SARS2 
_struct_ref.pdbx_db_accession          P0DTC1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_struct_ref.pdbx_align_begin           3264 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9BO8 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 306 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P0DTC1 
_struct_ref_seq.db_align_beg                  3264 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3569 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       306 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             9BO8 
_struct_ref_seq_dif.mon_id                       ILE 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      21 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   P0DTC1 
_struct_ref_seq_dif.db_mon_id                    THR 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          3284 
_struct_ref_seq_dif.details                      'engineered mutation' 
_struct_ref_seq_dif.pdbx_auth_seq_num            21 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2580  ? 
1 MORE         -10   ? 
1 'SSA (A^2)'  24850 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z     1.0000000000  0.0000000000 0.0000000000 0.0000000000   0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000  
2 'crystal symmetry operation' 2_556 -x,y,-z+1 -1.0000000000 0.0000000000 0.0000000000 -21.4470836867 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 47.2162946697 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 10  ? GLY A 15  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 41  ? CYS A 44  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 GLU A 47  ? ASN A 51  ? GLU A 47  ASN A 51  5 ? 5  
HELX_P HELX_P4  AA4 ASN A 53  ? ARG A 60  ? ASN A 53  ARG A 60  1 ? 8  
HELX_P HELX_P5  AA5 SER A 62  ? HIS A 64  ? SER A 62  HIS A 64  5 ? 3  
HELX_P HELX_P6  AA6 ILE A 200 ? ASN A 214 ? ILE A 200 ASN A 214 1 ? 15 
HELX_P HELX_P7  AA7 THR A 226 ? TYR A 237 ? THR A 226 TYR A 237 1 ? 12 
HELX_P HELX_P8  AA8 THR A 243 ? LEU A 250 ? THR A 243 LEU A 250 1 ? 8  
HELX_P HELX_P9  AA9 LEU A 250 ? GLY A 258 ? LEU A 250 GLY A 258 1 ? 9  
HELX_P HELX_P10 AB1 ALA A 260 ? GLY A 275 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P11 AB2 THR A 292 ? CYS A 300 ? THR A 292 CYS A 300 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            covale1 
_struct_conn.conn_type_id                  covale 
_struct_conn.pdbx_leaving_atom_flag        one 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            145 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           B 
_struct_conn.ptnr2_label_comp_id           UED 
_struct_conn.ptnr2_label_seq_id            . 
_struct_conn.ptnr2_label_atom_id           C21 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             145 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            UED 
_struct_conn.ptnr2_auth_seq_id             401 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               1.768 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      UED 
_pdbx_modification_feature.label_asym_id                      B 
_pdbx_modification_feature.label_seq_id                       . 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      145 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       UED 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        401 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       145 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               C21 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                CYS 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        UED 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Covalent chemical modification' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 73  ? LEU A 75  ? VAL A 73  LEU A 75  
AA1 2 PHE A 66  ? ALA A 70  ? PHE A 66  ALA A 70  
AA1 3 MET A 17  ? CYS A 22  ? MET A 17  CYS A 22  
AA1 4 THR A 25  ? LEU A 32  ? THR A 25  LEU A 32  
AA1 5 VAL A 35  ? PRO A 39  ? VAL A 35  PRO A 39  
AA1 6 VAL A 86  ? VAL A 91  ? VAL A 86  VAL A 91  
AA1 7 VAL A 77  ? GLN A 83  ? VAL A 77  GLN A 83  
AA2 1 LYS A 100 ? PHE A 103 ? LYS A 100 PHE A 103 
AA2 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA2 3 VAL A 148 ? ASP A 153 ? VAL A 148 ASP A 153 
AA2 4 THR A 111 ? TYR A 118 ? THR A 111 TYR A 118 
AA2 5 SER A 121 ? ALA A 129 ? SER A 121 ALA A 129 
AA3 1 LYS A 100 ? PHE A 103 ? LYS A 100 PHE A 103 
AA3 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA3 3 HIS A 172 ? THR A 175 ? HIS A 172 THR A 175 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL A 73  ? O VAL A 73  N ALA A 70  ? N ALA A 70  
AA1 2 3 O LEU A 67  ? O LEU A 67  N ILE A 21  ? N ILE A 21  
AA1 3 4 N VAL A 20  ? N VAL A 20  O LEU A 27  ? O LEU A 27  
AA1 4 5 N LEU A 32  ? N LEU A 32  O VAL A 35  ? O VAL A 35  
AA1 5 6 N CYS A 38  ? N CYS A 38  O LEU A 87  ? O LEU A 87  
AA1 6 7 O LYS A 88  ? O LYS A 88  N SER A 81  ? N SER A 81  
AA2 1 2 N LYS A 100 ? N LYS A 100 O VAL A 157 ? O VAL A 157 
AA2 2 3 O SER A 158 ? O SER A 158 N ASN A 151 ? N ASN A 151 
AA2 3 4 O PHE A 150 ? O PHE A 150 N SER A 113 ? N SER A 113 
AA2 4 5 N ALA A 116 ? N ALA A 116 O SER A 123 ? O SER A 123 
AA3 1 2 N LYS A 100 ? N LYS A 100 O VAL A 157 ? O VAL A 157 
AA3 2 3 N MET A 165 ? N MET A 165 O ALA A 173 ? O ALA A 173 
# 
_pdbx_entry_details.entry_id                   9BO8 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 33  ? ? 51.34  -132.19 
2 1 MET A 49  ? ? -65.45 4.27    
3 1 ASN A 84  ? ? 57.70  -122.19 
4 1 TYR A 154 ? ? 60.09  -116.95 
# 
_pdbx_molecule_features.prd_id    PRD_002495 
_pdbx_molecule_features.name      GC376 
_pdbx_molecule_features.type      Peptide-like 
_pdbx_molecule_features.class     Inhibitor 
_pdbx_molecule_features.details   ? 
# 
_pdbx_molecule.instance_id   1 
_pdbx_molecule.prd_id        PRD_002495 
_pdbx_molecule.asym_id       B 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 661 ? C HOH . 
2 1 A HOH 690 ? C HOH . 
3 1 A HOH 695 ? C HOH . 
4 1 A HOH 759 ? C HOH . 
5 1 A HOH 771 ? C HOH . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 -x,y,-z         
3 x+1/2,y+1/2,z   
4 -x+1/2,y+1/2,-z 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A SER 301 ? A SER 301 
2 1 Y 1 A GLY 302 ? A GLY 302 
3 1 Y 1 A VAL 303 ? A VAL 303 
4 1 Y 1 A THR 304 ? A THR 304 
5 1 Y 1 A PHE 305 ? A PHE 305 
6 1 Y 1 A GLN 306 ? A GLN 306 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PRO N    N N N 273 
PRO CA   C N S 274 
PRO C    C N N 275 
PRO O    O N N 276 
PRO CB   C N N 277 
PRO CG   C N N 278 
PRO CD   C N N 279 
PRO OXT  O N N 280 
PRO H    H N N 281 
PRO HA   H N N 282 
PRO HB2  H N N 283 
PRO HB3  H N N 284 
PRO HG2  H N N 285 
PRO HG3  H N N 286 
PRO HD2  H N N 287 
PRO HD3  H N N 288 
PRO HXT  H N N 289 
SER N    N N N 290 
SER CA   C N S 291 
SER C    C N N 292 
SER O    O N N 293 
SER CB   C N N 294 
SER OG   O N N 295 
SER OXT  O N N 296 
SER H    H N N 297 
SER H2   H N N 298 
SER HA   H N N 299 
SER HB2  H N N 300 
SER HB3  H N N 301 
SER HG   H N N 302 
SER HXT  H N N 303 
THR N    N N N 304 
THR CA   C N S 305 
THR C    C N N 306 
THR O    O N N 307 
THR CB   C N R 308 
THR OG1  O N N 309 
THR CG2  C N N 310 
THR OXT  O N N 311 
THR H    H N N 312 
THR H2   H N N 313 
THR HA   H N N 314 
THR HB   H N N 315 
THR HG1  H N N 316 
THR HG21 H N N 317 
THR HG22 H N N 318 
THR HG23 H N N 319 
THR HXT  H N N 320 
TRP N    N N N 321 
TRP CA   C N S 322 
TRP C    C N N 323 
TRP O    O N N 324 
TRP CB   C N N 325 
TRP CG   C Y N 326 
TRP CD1  C Y N 327 
TRP CD2  C Y N 328 
TRP NE1  N Y N 329 
TRP CE2  C Y N 330 
TRP CE3  C Y N 331 
TRP CZ2  C Y N 332 
TRP CZ3  C Y N 333 
TRP CH2  C Y N 334 
TRP OXT  O N N 335 
TRP H    H N N 336 
TRP H2   H N N 337 
TRP HA   H N N 338 
TRP HB2  H N N 339 
TRP HB3  H N N 340 
TRP HD1  H N N 341 
TRP HE1  H N N 342 
TRP HE3  H N N 343 
TRP HZ2  H N N 344 
TRP HZ3  H N N 345 
TRP HH2  H N N 346 
TRP HXT  H N N 347 
TYR N    N N N 348 
TYR CA   C N S 349 
TYR C    C N N 350 
TYR O    O N N 351 
TYR CB   C N N 352 
TYR CG   C Y N 353 
TYR CD1  C Y N 354 
TYR CD2  C Y N 355 
TYR CE1  C Y N 356 
TYR CE2  C Y N 357 
TYR CZ   C Y N 358 
TYR OH   O N N 359 
TYR OXT  O N N 360 
TYR H    H N N 361 
TYR H2   H N N 362 
TYR HA   H N N 363 
TYR HB2  H N N 364 
TYR HB3  H N N 365 
TYR HD1  H N N 366 
TYR HD2  H N N 367 
TYR HE1  H N N 368 
TYR HE2  H N N 369 
TYR HH   H N N 370 
TYR HXT  H N N 371 
UED C7   C N N 372 
UED O8   O N N 373 
UED C9   C N N 374 
UED O10  O N N 375 
UED C1   C Y N 376 
UED C2   C Y N 377 
UED C3   C Y N 378 
UED C4   C Y N 379 
UED C5   C Y N 380 
UED C6   C Y N 381 
UED N11  N N N 382 
UED C12  C N S 383 
UED C17  C N N 384 
UED O18  O N N 385 
UED C13  C N N 386 
UED C14  C N N 387 
UED C15  C N N 388 
UED C16  C N N 389 
UED N19  N N N 390 
UED C20  C N S 391 
UED C21  C N N 392 
UED O22  O N N 393 
UED C24  C N N 394 
UED C25  C N S 395 
UED C26  C N N 396 
UED C27  C N N 397 
UED N28  N N N 398 
UED C29  C N N 399 
UED O30  O N N 400 
UED H1   H N N 401 
UED H2   H N N 402 
UED H3   H N N 403 
UED H4   H N N 404 
UED H5   H N N 405 
UED H6   H N N 406 
UED H7   H N N 407 
UED H8   H N N 408 
UED H9   H N N 409 
UED H10  H N N 410 
UED H11  H N N 411 
UED H12  H N N 412 
UED H13  H N N 413 
UED H14  H N N 414 
UED H15  H N N 415 
UED H16  H N N 416 
UED H17  H N N 417 
UED H18  H N N 418 
UED H19  H N N 419 
UED H20  H N N 420 
UED H21  H N N 421 
UED H22  H N N 422 
UED H23  H N N 423 
UED H24  H N N 424 
UED H25  H N N 425 
UED H26  H N N 426 
UED H27  H N N 427 
UED H28  H N N 428 
UED H29  H N N 429 
UED H30  H N N 430 
UED H31  H N N 431 
VAL N    N N N 432 
VAL CA   C N S 433 
VAL C    C N N 434 
VAL O    O N N 435 
VAL CB   C N N 436 
VAL CG1  C N N 437 
VAL CG2  C N N 438 
VAL OXT  O N N 439 
VAL H    H N N 440 
VAL H2   H N N 441 
VAL HA   H N N 442 
VAL HB   H N N 443 
VAL HG11 H N N 444 
VAL HG12 H N N 445 
VAL HG13 H N N 446 
VAL HG21 H N N 447 
VAL HG22 H N N 448 
VAL HG23 H N N 449 
VAL HXT  H N N 450 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
UED C16 C14  sing N N 358 
UED C3  C2   doub Y N 359 
UED C3  C4   sing Y N 360 
UED C2  C1   sing Y N 361 
UED C14 C13  sing N N 362 
UED C14 C15  sing N N 363 
UED C13 C12  sing N N 364 
UED C4  C5   doub Y N 365 
UED O8  C7   sing N N 366 
UED O8  C9   sing N N 367 
UED N11 C12  sing N N 368 
UED N11 C9   sing N N 369 
UED C1  C7   sing N N 370 
UED C1  C6   doub Y N 371 
UED O18 C17  doub N N 372 
UED C5  C6   sing Y N 373 
UED C12 C17  sing N N 374 
UED C9  O10  doub N N 375 
UED C17 N19  sing N N 376 
UED C26 C27  sing N N 377 
UED C26 C25  sing N N 378 
UED N19 C20  sing N N 379 
UED C20 C21  sing N N 380 
UED C20 C24  sing N N 381 
UED C27 N28  sing N N 382 
UED O22 C21  sing N N 383 
UED C25 C24  sing N N 384 
UED C25 C29  sing N N 385 
UED N28 C29  sing N N 386 
UED C29 O30  doub N N 387 
UED C7  H1   sing N N 388 
UED C7  H2   sing N N 389 
UED C2  H3   sing N N 390 
UED C3  H4   sing N N 391 
UED C4  H5   sing N N 392 
UED C5  H6   sing N N 393 
UED C6  H7   sing N N 394 
UED N11 H8   sing N N 395 
UED C12 H9   sing N N 396 
UED C13 H10  sing N N 397 
UED C13 H11  sing N N 398 
UED C14 H12  sing N N 399 
UED C15 H13  sing N N 400 
UED C15 H14  sing N N 401 
UED C15 H15  sing N N 402 
UED C16 H16  sing N N 403 
UED C16 H17  sing N N 404 
UED C16 H18  sing N N 405 
UED N19 H19  sing N N 406 
UED C20 H20  sing N N 407 
UED C24 H21  sing N N 408 
UED C24 H22  sing N N 409 
UED C25 H23  sing N N 410 
UED C26 H24  sing N N 411 
UED C26 H25  sing N N 412 
UED C27 H26  sing N N 413 
UED C27 H27  sing N N 414 
UED N28 H28  sing N N 415 
UED C21 H29  sing N N 416 
UED C21 H30  sing N N 417 
UED O22 H31  sing N N 418 
VAL N   CA   sing N N 419 
VAL N   H    sing N N 420 
VAL N   H2   sing N N 421 
VAL CA  C    sing N N 422 
VAL CA  CB   sing N N 423 
VAL CA  HA   sing N N 424 
VAL C   O    doub N N 425 
VAL C   OXT  sing N N 426 
VAL CB  CG1  sing N N 427 
VAL CB  CG2  sing N N 428 
VAL CB  HB   sing N N 429 
VAL CG1 HG11 sing N N 430 
VAL CG1 HG12 sing N N 431 
VAL CG1 HG13 sing N N 432 
VAL CG2 HG21 sing N N 433 
VAL CG2 HG22 sing N N 434 
VAL CG2 HG23 sing N N 435 
VAL OXT HXT  sing N N 436 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' 'P30 GM133893' 1 
'Department of Energy (DOE, United States)'                                                'United States' KP1607011      2 
'Other government'                                                                         ?               DE-SC0012704   3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7NF5 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'C 1 2 1' 
_space_group.name_Hall        'C 2y' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9BO8 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.010083 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.004580 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.012407 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.021179 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . SER A 1 1   ? 0.07220   20.72375 36.90423  1.000 23.94573  ? 1   SER A N    1 
ATOM   2    C CA   . SER A 1 1   ? 0.01119   19.67477 35.90640  1.000 22.17163  ? 1   SER A CA   1 
ATOM   3    C C    . SER A 1 1   ? -1.35331  19.58011 35.24591  1.000 25.74649  ? 1   SER A C    1 
ATOM   4    O O    . SER A 1 1   ? -2.20646  20.44607 35.43694  1.000 20.12110  ? 1   SER A O    1 
ATOM   5    C CB   . SER A 1 1   ? 0.41383   18.32391 36.51787  1.000 36.71827  ? 1   SER A CB   1 
ATOM   6    O OG   . SER A 1 1   ? -0.59812  17.81147 37.33071  1.000 31.16252  ? 1   SER A OG   1 
ATOM   7    H H1   . SER A 1 1   ? -0.50262  20.54373 37.55942  1.000 28.73488  ? 1   SER A H1   1 
ATOM   8    H H2   . SER A 1 1   ? 0.89645   20.76920 37.23684  1.000 28.73488  ? 1   SER A H2   1 
ATOM   9    H H3   . SER A 1 1   ? -0.13977  21.50257 36.52924  1.000 28.73488  ? 1   SER A H3   1 
ATOM   10   H HA   . SER A 1 1   ? 0.64475   19.88850 35.20368  1.000 26.60596  ? 1   SER A HA   1 
ATOM   11   H HB2  . SER A 1 1   ? 0.58878   17.69472 35.80064  1.000 44.06192  ? 1   SER A HB2  1 
ATOM   12   H HB3  . SER A 1 1   ? 1.21336   18.44775 37.05295  1.000 44.06192  ? 1   SER A HB3  1 
ATOM   13   H HG   . SER A 1 1   ? -0.40908  17.02723 37.56487  1.000 37.39502  ? 1   SER A HG   1 
ATOM   14   N N    . GLY A 1 2   ? -1.54718  18.52835 34.45642  1.000 23.50202  ? 2   GLY A N    1 
ATOM   15   C CA   . GLY A 1 2   ? -2.70222  18.32834 33.61842  1.000 19.49364  ? 2   GLY A CA   1 
ATOM   16   C C    . GLY A 1 2   ? -2.38088  18.67232 32.17152  1.000 21.11231  ? 2   GLY A C    1 
ATOM   17   O O    . GLY A 1 2   ? -1.46401  19.41011 31.87688  1.000 26.20490  ? 2   GLY A O    1 
ATOM   18   H H    . GLY A 1 2   ? -0.98411  17.88164 34.39069  1.000 28.20243  ? 2   GLY A H    1 
ATOM   19   H HA2  . GLY A 1 2   ? -2.98434  17.40143 33.66464  1.000 23.39237  ? 2   GLY A HA2  1 
ATOM   20   H HA3  . GLY A 1 2   ? -3.42896  18.89509 33.92099  1.000 23.39237  ? 2   GLY A HA3  1 
ATOM   21   N N    . PHE A 1 3   ? -3.18435  18.12519 31.27565  1.000 21.74746  ? 3   PHE A N    1 
ATOM   22   C CA   . PHE A 1 3   ? -2.93639  18.33342 29.84085  1.000 19.35844  ? 3   PHE A CA   1 
ATOM   23   C C    . PHE A 1 3   ? -4.25741  18.39906 29.12754  1.000 20.58044  ? 3   PHE A C    1 
ATOM   24   O O    . PHE A 1 3   ? -5.02453  17.43271 29.12750  1.000 24.79337  ? 3   PHE A O    1 
ATOM   25   C CB   . PHE A 1 3   ? -2.04897  17.22682 29.26721  1.000 21.80160  ? 3   PHE A CB   1 
ATOM   26   C CG   . PHE A 1 3   ? -1.45929  17.58131 27.91613  1.000 23.14416  ? 3   PHE A CG   1 
ATOM   27   C CD1  . PHE A 1 3   ? -0.39884  18.43445 27.84176  1.000 23.80381  ? 3   PHE A CD1  1 
ATOM   28   C CD2  . PHE A 1 3   ? -1.99981  17.08015 26.76050  1.000 23.34758  ? 3   PHE A CD2  1 
ATOM   29   C CE1  . PHE A 1 3   ? 0.13632   18.80375 26.61664  1.000 27.40874  ? 3   PHE A CE1  1 
ATOM   30   C CE2  . PHE A 1 3   ? -1.47500  17.42074 25.53256  1.000 29.38616  ? 3   PHE A CE2  1 
ATOM   31   C CZ   . PHE A 1 3   ? -0.39728  18.27419 25.47446  1.000 25.02081  ? 3   PHE A CZ   1 
ATOM   32   H H    . PHE A 1 3   ? -3.86841  17.63759 31.45982  1.000 26.09695  ? 3   PHE A H    1 
ATOM   33   H HA   . PHE A 1 3   ? -2.48274  19.18068 29.70951  1.000 23.23012  ? 3   PHE A HA   1 
ATOM   34   H HB2  . PHE A 1 3   ? -1.31537  17.06210 29.88006  1.000 26.16192  ? 3   PHE A HB2  1 
ATOM   35   H HB3  . PHE A 1 3   ? -2.57922  16.42163 29.16041  1.000 26.16192  ? 3   PHE A HB3  1 
ATOM   36   H HD1  . PHE A 1 3   ? -0.02854  18.77406 28.62435  1.000 28.56457  ? 3   PHE A HD1  1 
ATOM   37   H HD2  . PHE A 1 3   ? -2.72853  16.50410 26.80554  1.000 28.01710  ? 3   PHE A HD2  1 
ATOM   38   H HE1  . PHE A 1 3   ? 0.84689   19.40213 26.57269  1.000 32.89048  ? 3   PHE A HE1  1 
ATOM   39   H HE2  . PHE A 1 3   ? -1.84530  17.07743 24.75159  1.000 35.26339  ? 3   PHE A HE2  1 
ATOM   40   H HZ   . PHE A 1 3   ? -0.02784  18.49320 24.64957  1.000 30.02497  ? 3   PHE A HZ   1 
ATOM   41   N N    . ARG A 1 4   ? -4.54463  19.55488 28.51148  1.000 21.44865  ? 4   ARG A N    1 
ATOM   42   C CA   A ARG A 1 4   ? -5.82145  19.77824 27.85751  0.500 18.59030  ? 4   ARG A CA   1 
ATOM   43   C CA   B ARG A 1 4   ? -5.81625  19.77834 27.85714  0.500 18.57976  ? 4   ARG A CA   1 
ATOM   44   C C    . ARG A 1 4   ? -5.58167  20.31980 26.45179  1.000 19.03276  ? 4   ARG A C    1 
ATOM   45   O O    . ARG A 1 4   ? -4.58058  20.98025 26.19951  1.000 23.18751  ? 4   ARG A O    1 
ATOM   46   C CB   A ARG A 1 4   ? -6.68942  20.81193 28.65757  0.500 21.15390  ? 4   ARG A CB   1 
ATOM   47   C CB   B ARG A 1 4   ? -6.63203  20.81216 28.67962  0.500 21.06229  ? 4   ARG A CB   1 
ATOM   48   C CG   A ARG A 1 4   ? -7.46183  20.23931 29.86790  0.500 21.67577  ? 4   ARG A CG   1 
ATOM   49   C CG   B ARG A 1 4   ? -6.94711  20.32820 30.09308  0.500 19.12570  ? 4   ARG A CG   1 
ATOM   50   C CD   A ARG A 1 4   ? -8.80726  19.61072 29.46533  0.500 27.51631  ? 4   ARG A CD   1 
ATOM   51   C CD   B ARG A 1 4   ? -7.80751  19.06783 30.05493  0.500 21.96825  ? 4   ARG A CD   1 
ATOM   52   N NE   A ARG A 1 4   ? -9.70818  19.44282 30.61714  0.500 24.48552  ? 4   ARG A NE   1 
ATOM   53   N NE   B ARG A 1 4   ? -8.91382  19.24536 29.11463  0.500 22.23626  ? 4   ARG A NE   1 
ATOM   54   C CZ   A ARG A 1 4   ? -10.88963 18.83934 30.55377  0.500 26.75492  ? 4   ARG A CZ   1 
ATOM   55   C CZ   B ARG A 1 4   ? -9.96338  20.02115 29.35129  0.500 23.97745  ? 4   ARG A CZ   1 
ATOM   56   N NH1  A ARG A 1 4   ? -11.33701 18.30245 29.42268  0.500 24.74963  ? 4   ARG A NH1  1 
ATOM   57   N NH1  B ARG A 1 4   ? -10.12235 20.63099 30.53342  0.500 18.59703  ? 4   ARG A NH1  1 
ATOM   58   N NH2  A ARG A 1 4   ? -11.64381 18.76771 31.64775  0.500 17.96521  ? 4   ARG A NH2  1 
ATOM   59   N NH2  B ARG A 1 4   ? -10.87245 20.18680 28.39775  0.500 20.67980  ? 4   ARG A NH2  1 
ATOM   60   H H    . ARG A 1 4   ? -4.00429  20.22243 28.46651  1.000 25.73838  ? 4   ARG A H    1 
ATOM   61   H HA   . ARG A 1 4   ? -6.30569  18.94028 27.79244  1.000 22.29571  ? 4   ARG A HA   1 
ATOM   62   H HB2  A ARG A 1 4   ? -6.10259  21.50767 28.99294  0.500 25.38469  ? 4   ARG A HB2  1 
ATOM   63   H HB2  B ARG A 1 4   ? -6.12039  21.63319 28.75056  0.500 25.27475  ? 4   ARG A HB2  1 
ATOM   64   H HB3  A ARG A 1 4   ? -7.34409  21.19349 28.05200  0.500 25.38469  ? 4   ARG A HB3  1 
ATOM   65   H HB3  B ARG A 1 4   ? -7.47252  20.98312 28.22657  0.500 25.27475  ? 4   ARG A HB3  1 
ATOM   66   H HG2  A ARG A 1 4   ? -6.92390  19.55211 30.29133  0.500 26.01092  ? 4   ARG A HG2  1 
ATOM   67   H HG2  B ARG A 1 4   ? -6.12041  20.12268 30.55701  0.500 22.95084  ? 4   ARG A HG2  1 
ATOM   68   H HG3  A ARG A 1 4   ? -7.64109  20.95517 30.49744  0.500 26.01092  ? 4   ARG A HG3  1 
ATOM   69   H HG3  B ARG A 1 4   ? -7.43305  21.01833 30.57107  0.500 22.95084  ? 4   ARG A HG3  1 
ATOM   70   H HD2  A ARG A 1 4   ? -9.24667  20.18529 28.81906  0.500 33.01957  ? 4   ARG A HD2  1 
ATOM   71   H HD2  B ARG A 1 4   ? -7.27027  18.31410 29.76484  0.500 26.36190  ? 4   ARG A HD2  1 
ATOM   72   H HD3  A ARG A 1 4   ? -8.64693  18.73643 29.07697  0.500 33.01957  ? 4   ARG A HD3  1 
ATOM   73   H HD3  B ARG A 1 4   ? -8.17303  18.89491 30.93663  0.500 26.36190  ? 4   ARG A HD3  1 
ATOM   74   H HE   A ARG A 1 4   ? -9.45412  19.75443 31.37737  0.500 29.38262  ? 4   ARG A HE   1 
ATOM   75   H HE   B ARG A 1 4   ? -8.88198  18.82295 28.36620  0.500 26.68351  ? 4   ARG A HE   1 
ATOM   76   H HH11 A ARG A 1 4   ? -10.85813 18.34124 28.70940  0.500 29.69956  ? 4   ARG A HH11 1 
ATOM   77   H HH11 B ARG A 1 4   ? -9.53809  20.52273 31.15513  0.500 22.31643  ? 4   ARG A HH11 1 
ATOM   78   H HH12 A ARG A 1 4   ? -12.10528 17.91640 29.40434  0.500 29.69956  ? 4   ARG A HH12 1 
ATOM   79   H HH12 B ARG A 1 4   ? -10.80866 21.13074 30.67061  0.500 22.31643  ? 4   ARG A HH12 1 
ATOM   80   H HH21 A ARG A 1 4   ? -11.36470 19.11011 32.38563  0.500 21.55826  ? 4   ARG A HH21 1 
ATOM   81   H HH21 B ARG A 1 4   ? -10.77628 19.79359 27.63898  0.500 24.81576  ? 4   ARG A HH21 1 
ATOM   82   H HH22 A ARG A 1 4   ? -12.41033 18.37901 31.61690  0.500 21.55826  ? 4   ARG A HH22 1 
ATOM   83   H HH22 B ARG A 1 4   ? -11.55741 20.68730 28.53893  0.500 24.81576  ? 4   ARG A HH22 1 
ATOM   84   N N    . LYS A 1 5   ? -6.52413  20.05671 25.56122  1.000 19.09619  ? 5   LYS A N    1 
ATOM   85   C CA   . LYS A 1 5   ? -6.53466  20.71827 24.26811  1.000 19.29691  ? 5   LYS A CA   1 
ATOM   86   C C    . LYS A 1 5   ? -6.88131  22.16999 24.52246  1.000 21.75504  ? 5   LYS A C    1 
ATOM   87   O O    . LYS A 1 5   ? -7.98458  22.48378 24.96247  1.000 27.48635  ? 5   LYS A O    1 
ATOM   88   C CB   . LYS A 1 5   ? -7.52865  20.03598 23.34876  1.000 23.17666  ? 5   LYS A CB   1 
ATOM   89   C CG   . LYS A 1 5   ? -7.12874  20.16786 21.88371  1.000 26.97912  ? 5   LYS A CG   1 
ATOM   90   C CD   . LYS A 1 5   ? -8.09886  19.41488 20.98146  1.000 35.42092  ? 5   LYS A CD   1 
ATOM   91   C CE   . LYS A 1 5   ? -7.94423  17.91437 21.09130  1.000 45.88155  ? 5   LYS A CE   1 
ATOM   92   N NZ   . LYS A 1 5   ? -7.11290  17.36916 19.99670  1.000 43.05299  ? 5   LYS A NZ   1 
ATOM   93   H H    . LYS A 1 5   ? -7.16809  19.49952 25.68153  1.000 22.91543  ? 5   LYS A H    1 
ATOM   94   H HA   . LYS A 1 5   ? -5.67101  20.66781 23.82939  1.000 23.15629  ? 5   LYS A HA   1 
ATOM   95   H HB2  . LYS A 1 5   ? -7.57128  19.09223 23.56880  1.000 27.81199  ? 5   LYS A HB2  1 
ATOM   96   H HB3  . LYS A 1 5   ? -8.40148  20.44322 23.46378  1.000 27.81199  ? 5   LYS A HB3  1 
ATOM   97   H HG2  . LYS A 1 5   ? -7.13717  21.10394 21.62960  1.000 32.37494  ? 5   LYS A HG2  1 
ATOM   98   H HG3  . LYS A 1 5   ? -6.24127  19.79755 21.75656  1.000 32.37494  ? 5   LYS A HG3  1 
ATOM   99   H HD2  . LYS A 1 5   ? -9.00778  19.64272 21.23217  1.000 42.50510  ? 5   LYS A HD2  1 
ATOM   100  H HD3  . LYS A 1 5   ? -7.93593  19.66732 20.05916  1.000 42.50510  ? 5   LYS A HD3  1 
ATOM   101  H HE2  . LYS A 1 5   ? -7.51728  17.69715 21.93477  1.000 55.05786  ? 5   LYS A HE2  1 
ATOM   102  H HE3  . LYS A 1 5   ? -8.81906  17.49789 21.04534  1.000 55.05786  ? 5   LYS A HE3  1 
ATOM   103  H HZ1  . LYS A 1 5   ? -7.41151  17.66401 19.21185  1.000 51.66358  ? 5   LYS A HZ1  1 
ATOM   104  H HZ2  . LYS A 1 5   ? -6.26726  17.62696 20.09934  1.000 51.66358  ? 5   LYS A HZ2  1 
ATOM   105  H HZ3  . LYS A 1 5   ? -7.14652  16.47982 20.00293  1.000 51.66358  ? 5   LYS A HZ3  1 
ATOM   106  N N    . MET A 1 6   ? -5.93687  23.05026 24.29906  1.000 16.44305  ? 6   MET A N    1 
ATOM   107  C CA   . MET A 1 6   ? -6.01791  24.43266 24.72830  1.000 18.85522  ? 6   MET A CA   1 
ATOM   108  C C    . MET A 1 6   ? -5.85371  25.36143 23.52923  1.000 20.28964  ? 6   MET A C    1 
ATOM   109  O O    . MET A 1 6   ? -4.90008  25.21323 22.75421  1.000 18.94627  ? 6   MET A O    1 
ATOM   110  C CB   . MET A 1 6   ? -4.87262  24.68414 25.75566  1.000 20.82067  ? 6   MET A CB   1 
ATOM   111  C CG   . MET A 1 6   ? -4.90839  25.97184 26.40948  1.000 41.18289  ? 6   MET A CG   1 
ATOM   112  S SD   . MET A 1 6   ? -3.49130  25.98829 27.51583  1.000 30.00763  ? 6   MET A SD   1 
ATOM   113  C CE   . MET A 1 6   ? -3.86119  24.67931 28.67164  1.000 24.28310  ? 6   MET A CE   1 
ATOM   114  H H    . MET A 1 6   ? -5.20640  22.86780 23.88346  1.000 19.73166  ? 6   MET A H    1 
ATOM   115  H HA   . MET A 1 6   ? -6.88200  24.61698 25.12865  1.000 22.62626  ? 6   MET A HA   1 
ATOM   116  H HB2  . MET A 1 6   ? -4.92633  24.00578 26.44692  1.000 24.98481  ? 6   MET A HB2  1 
ATOM   117  H HB3  . MET A 1 6   ? -4.02377  24.61778 25.29095  1.000 24.98481  ? 6   MET A HB3  1 
ATOM   118  H HG2  . MET A 1 6   ? -4.82903  26.68871 25.76086  1.000 49.41947  ? 6   MET A HG2  1 
ATOM   119  H HG3  . MET A 1 6   ? -5.72675  26.07531 26.91985  1.000 49.41947  ? 6   MET A HG3  1 
ATOM   120  H HE1  . MET A 1 6   ? -3.27018  24.75732 29.43684  1.000 29.13972  ? 6   MET A HE1  1 
ATOM   121  H HE2  . MET A 1 6   ? -4.78456  24.76166 28.95712  1.000 29.13972  ? 6   MET A HE2  1 
ATOM   122  H HE3  . MET A 1 6   ? -3.72514  23.82418 28.23444  1.000 29.13972  ? 6   MET A HE3  1 
ATOM   123  N N    . ALA A 1 7   ? -6.79005  26.27117 23.36431  1.000 16.60080  ? 7   ALA A N    1 
ATOM   124  C CA   . ALA A 1 7   ? -6.72467  27.27187 22.31719  1.000 15.16262  ? 7   ALA A CA   1 
ATOM   125  C C    . ALA A 1 7   ? -6.02503  28.53060 22.82644  1.000 17.52065  ? 7   ALA A C    1 
ATOM   126  O O    . ALA A 1 7   ? -5.88933  28.74031 24.03179  1.000 16.87692  ? 7   ALA A O    1 
ATOM   127  C CB   . ALA A 1 7   ? -8.11347  27.65744 21.85941  1.000 18.30911  ? 7   ALA A CB   1 
ATOM   128  H H    . ALA A 1 7   ? -7.49203  26.33345 23.85720  1.000 19.92096  ? 7   ALA A H    1 
ATOM   129  H HA   . ALA A 1 7   ? -6.23046  26.90480 21.56758  1.000 18.19514  ? 7   ALA A HA   1 
ATOM   130  H HB1  . ALA A 1 7   ? -8.04831  28.41359 21.25536  1.000 21.97093  ? 7   ALA A HB1  1 
ATOM   131  H HB2  . ALA A 1 7   ? -8.51622  26.90264 21.40228  1.000 21.97093  ? 7   ALA A HB2  1 
ATOM   132  H HB3  . ALA A 1 7   ? -8.64592  27.89763 22.63382  1.000 21.97093  ? 7   ALA A HB3  1 
ATOM   133  N N    . PHE A 1 8   ? -5.56823  29.35598 21.89590  1.000 14.85558  ? 8   PHE A N    1 
ATOM   134  C CA   . PHE A 1 8   ? -5.07073  30.66990 22.25110  1.000 13.54870  ? 8   PHE A CA   1 
ATOM   135  C C    . PHE A 1 8   ? -6.22393  31.57823 22.66679  1.000 14.83513  ? 8   PHE A C    1 
ATOM   136  O O    . PHE A 1 8   ? -7.36458  31.44048 22.20170  1.000 15.66317  ? 8   PHE A O    1 
ATOM   137  C CB   . PHE A 1 8   ? -4.31958  31.29282 21.04981  1.000 15.98501  ? 8   PHE A CB   1 
ATOM   138  C CG   . PHE A 1 8   ? -2.97482  30.70378 20.80638  1.000 18.51768  ? 8   PHE A CG   1 
ATOM   139  C CD1  . PHE A 1 8   ? -1.93043  30.96939 21.63547  1.000 20.34400  ? 8   PHE A CD1  1 
ATOM   140  C CD2  . PHE A 1 8   ? -2.77808  29.82699 19.75277  1.000 19.93698  ? 8   PHE A CD2  1 
ATOM   141  C CE1  . PHE A 1 8   ? -0.69180  30.41022 21.44218  1.000 23.90872  ? 8   PHE A CE1  1 
ATOM   142  C CE2  . PHE A 1 8   ? -1.52872  29.26240 19.53349  1.000 24.49057  ? 8   PHE A CE2  1 
ATOM   143  C CZ   . PHE A 1 8   ? -0.49276  29.56169 20.39751  1.000 23.43990  ? 8   PHE A CZ   1 
ATOM   144  H H    . PHE A 1 8   ? -5.53640  29.17819 21.05508  1.000 17.82670  ? 8   PHE A H    1 
ATOM   145  H HA   . PHE A 1 8   ? -4.45580  30.59951 22.99797  1.000 16.25844  ? 8   PHE A HA   1 
ATOM   146  H HB2  . PHE A 1 8   ? -4.84966  31.15951 20.24848  1.000 19.18201  ? 8   PHE A HB2  1 
ATOM   147  H HB3  . PHE A 1 8   ? -4.20086  32.24124 21.21509  1.000 19.18201  ? 8   PHE A HB3  1 
ATOM   148  H HD1  . PHE A 1 8   ? -2.05887  31.54608 22.35367  1.000 24.41280  ? 8   PHE A HD1  1 
ATOM   149  H HD2  . PHE A 1 8   ? -3.48669  29.61514 19.18896  1.000 23.92437  ? 8   PHE A HD2  1 
ATOM   150  H HE1  . PHE A 1 8   ? 0.00729   30.61026 22.02197  1.000 28.69046  ? 8   PHE A HE1  1 
ATOM   151  H HE2  . PHE A 1 8   ? -1.39079  28.68974 18.81382  1.000 29.38869  ? 8   PHE A HE2  1 
ATOM   152  H HZ   . PHE A 1 8   ? 0.34520   29.18097 20.26419  1.000 28.12788  ? 8   PHE A HZ   1 
ATOM   153  N N    . PRO A 1 9   ? -5.97413  32.48971 23.59872  1.000 16.28030  ? 9   PRO A N    1 
ATOM   154  C CA   . PRO A 1 9   ? -6.99569  33.47767 23.91752  1.000 16.59582  ? 9   PRO A CA   1 
ATOM   155  C C    . PRO A 1 9   ? -7.37891  34.24072 22.64743  1.000 19.04626  ? 9   PRO A C    1 
ATOM   156  O O    . PRO A 1 9   ? -6.52237  34.60387 21.83422  1.000 20.13269  ? 9   PRO A O    1 
ATOM   157  C CB   . PRO A 1 9   ? -6.29664  34.40224 24.93293  1.000 18.90389  ? 9   PRO A CB   1 
ATOM   158  C CG   . PRO A 1 9   ? -5.11771  33.63917 25.45288  1.000 20.90265  ? 9   PRO A CG   1 
ATOM   159  C CD   . PRO A 1 9   ? -4.67921  32.75959 24.24183  1.000 17.10117  ? 9   PRO A CD   1 
ATOM   160  H HA   . PRO A 1 9   ? -7.77410  33.07321 24.33152  1.000 19.91498  ? 9   PRO A HA   1 
ATOM   161  H HB2  . PRO A 1 9   ? -6.00944  35.21506 24.48824  1.000 22.68467  ? 9   PRO A HB2  1 
ATOM   162  H HB3  . PRO A 1 9   ? -6.91018  34.61701 25.65289  1.000 22.68467  ? 9   PRO A HB3  1 
ATOM   163  H HG2  . PRO A 1 9   ? -4.41219  34.25056 25.71621  1.000 25.08318  ? 9   PRO A HG2  1 
ATOM   164  H HG3  . PRO A 1 9   ? -5.38022  33.09034 26.20837  1.000 25.08318  ? 9   PRO A HG3  1 
ATOM   165  H HD2  . PRO A 1 9   ? -4.08539  33.24620 23.64897  1.000 20.52140  ? 9   PRO A HD2  1 
ATOM   166  H HD3  . PRO A 1 9   ? -4.25409  31.93924 24.53712  1.000 20.52140  ? 9   PRO A HD3  1 
ATOM   167  N N    . SER A 1 10  ? -8.66556  34.44276 22.48321  1.000 18.77580  ? 10  SER A N    1 
ATOM   168  C CA   . SER A 1 10  ? -9.23066  34.86317 21.19478  1.000 17.09549  ? 10  SER A CA   1 
ATOM   169  C C    . SER A 1 10  ? -9.47943  36.35762 21.09591  1.000 17.97740  ? 10  SER A C    1 
ATOM   170  O O    . SER A 1 10  ? -9.88253  36.82711 20.02176  1.000 16.27859  ? 10  SER A O    1 
ATOM   171  C CB   . SER A 1 10  ? -10.52662 34.11574 20.92374  1.000 18.58955  ? 10  SER A CB   1 
ATOM   172  O OG   . SER A 1 10  ? -11.46971 34.32899 21.98258  1.000 19.82510  ? 10  SER A OG   1 
ATOM   173  H H    . SER A 1 10  ? -9.25173  34.34488 23.10484  1.000 22.53096  ? 10  SER A H    1 
ATOM   174  H HA   . SER A 1 10  ? -8.59437  34.63073 20.50052  1.000 20.51458  ? 10  SER A HA   1 
ATOM   175  H HB2  . SER A 1 10  ? -10.90815 34.43671 20.09169  1.000 22.30747  ? 10  SER A HB2  1 
ATOM   176  H HB3  . SER A 1 10  ? -10.33593 33.16700 20.85708  1.000 22.30747  ? 10  SER A HB3  1 
ATOM   177  H HG   . SER A 1 10  ? -12.23387 34.07660 21.74184  1.000 23.79012  ? 10  SER A HG   1 
ATOM   178  N N    . GLY A 1 11  ? -9.28900  37.10798 22.17328  1.000 18.67022  ? 11  GLY A N    1 
ATOM   179  C CA   . GLY A 1 11  ? -9.65956  38.52555 22.15606  1.000 18.24413  ? 11  GLY A CA   1 
ATOM   180  C C    . GLY A 1 11  ? -9.13863  39.29477 20.95316  1.000 18.26780  ? 11  GLY A C    1 
ATOM   181  O O    . GLY A 1 11  ? -9.87084  40.09680 20.36113  1.000 20.78033  ? 11  GLY A O    1 
ATOM   182  H H    . GLY A 1 11  ? -8.95388  36.83178 22.91558  1.000 22.40426  ? 11  GLY A H    1 
ATOM   183  H HA2  . GLY A 1 11  ? -10.62695 38.59658 22.15817  1.000 21.89295  ? 11  GLY A HA2  1 
ATOM   184  H HA3  . GLY A 1 11  ? -9.30996  38.95053 22.95485  1.000 21.89295  ? 11  GLY A HA3  1 
ATOM   185  N N    . LYS A 1 12  ? -7.85184  39.11965 20.64215  1.000 18.68202  ? 12  LYS A N    1 
ATOM   186  C CA   . LYS A 1 12  ? -7.24577  39.87946 19.53468  1.000 15.76883  ? 12  LYS A CA   1 
ATOM   187  C C    . LYS A 1 12  ? -7.94203  39.62154 18.21425  1.000 20.60835  ? 12  LYS A C    1 
ATOM   188  O O    . LYS A 1 12  ? -8.01876  40.52508 17.36161  1.000 20.59878  ? 12  LYS A O    1 
ATOM   189  C CB   . LYS A 1 12  ? -5.76815  39.55853 19.42266  1.000 19.00772  ? 12  LYS A CB   1 
ATOM   190  C CG   . LYS A 1 12  ? -4.91422  40.21100 20.51023  1.000 24.08393  ? 12  LYS A CG   1 
ATOM   191  C CD   . LYS A 1 12  ? -3.44117  39.88263 20.29103  1.000 23.63770  ? 12  LYS A CD   1 
ATOM   192  C CE   . LYS A 1 12  ? -2.53726  40.73573 21.19878  1.000 38.60218  ? 12  LYS A CE   1 
ATOM   193  N NZ   . LYS A 1 12  ? -2.79739  40.50728 22.64093  1.000 52.08505  ? 12  LYS A NZ   1 
ATOM   194  H H    . LYS A 1 12  ? -7.31581  38.58065 21.04433  1.000 22.41843  ? 12  LYS A H    1 
ATOM   195  H HA   . LYS A 1 12  ? -7.33402  40.82480 19.73329  1.000 18.92260  ? 12  LYS A HA   1 
ATOM   196  H HB2  . LYS A 1 12  ? -5.65135  38.59797 19.49035  1.000 22.80927  ? 12  LYS A HB2  1 
ATOM   197  H HB3  . LYS A 1 12  ? -5.44482  39.87233 18.56365  1.000 22.80927  ? 12  LYS A HB3  1 
ATOM   198  H HG2  . LYS A 1 12  ? -5.02551  41.17407 20.47846  1.000 28.90071  ? 12  LYS A HG2  1 
ATOM   199  H HG3  . LYS A 1 12  ? -5.18099  39.87472 21.38008  1.000 28.90071  ? 12  LYS A HG3  1 
ATOM   200  H HD2  . LYS A 1 12  ? -3.28558  38.94752 20.49656  1.000 28.36525  ? 12  LYS A HD2  1 
ATOM   201  H HD3  . LYS A 1 12  ? -3.20486  40.06315 19.36773  1.000 28.36525  ? 12  LYS A HD3  1 
ATOM   202  H HE2  . LYS A 1 12  ? -1.60995  40.51268 21.02202  1.000 46.32262  ? 12  LYS A HE2  1 
ATOM   203  H HE3  . LYS A 1 12  ? -2.69447  41.67418 21.01039  1.000 46.32262  ? 12  LYS A HE3  1 
ATOM   204  H HZ1  . LYS A 1 12  ? -2.19588  40.94278 23.13146  1.000 62.50206  ? 12  LYS A HZ1  1 
ATOM   205  H HZ2  . LYS A 1 12  ? -3.61040  40.80024 22.85373  1.000 62.50206  ? 12  LYS A HZ2  1 
ATOM   206  H HZ3  . LYS A 1 12  ? -2.74606  39.63816 22.82555  1.000 62.50206  ? 12  LYS A HZ3  1 
ATOM   207  N N    . VAL A 1 13  ? -8.47142  38.42734 18.02526  1.000 17.78414  ? 13  VAL A N    1 
ATOM   208  C CA   . VAL A 1 13  ? -9.19169  38.10026 16.80483  1.000 16.43153  ? 13  VAL A CA   1 
ATOM   209  C C    . VAL A 1 13  ? -10.65121 38.51508 16.85515  1.000 18.46936  ? 13  VAL A C    1 
ATOM   210  O O    . VAL A 1 13  ? -11.20151 38.98258 15.87804  1.000 18.45152  ? 13  VAL A O    1 
ATOM   211  C CB   . VAL A 1 13  ? -9.01958  36.59609 16.50282  1.000 16.47453  ? 13  VAL A CB   1 
ATOM   212  C CG1  . VAL A 1 13  ? -9.74142  36.22023 15.18715  1.000 20.16116  ? 13  VAL A CG1  1 
ATOM   213  C CG2  . VAL A 1 13  ? -7.54284  36.25175 16.40247  1.000 18.27406  ? 13  VAL A CG2  1 
ATOM   214  H H    . VAL A 1 13  ? -8.42869  37.78147 18.59149  1.000 21.34096  ? 13  VAL A H    1 
ATOM   215  H HA   . VAL A 1 13  ? -8.80044  38.60471 16.07452  1.000 19.71784  ? 13  VAL A HA   1 
ATOM   216  H HB   . VAL A 1 13  ? -9.41401  36.08268 17.22513  1.000 19.76943  ? 13  VAL A HB   1 
ATOM   217  H HG11 . VAL A 1 13  ? -10.64824 36.56340 15.21530  1.000 24.19340  ? 13  VAL A HG11 1 
ATOM   218  H HG12 . VAL A 1 13  ? -9.26220  36.61281 14.44074  1.000 24.19340  ? 13  VAL A HG12 1 
ATOM   219  H HG13 . VAL A 1 13  ? -9.75586  35.25429 15.09969  1.000 24.19340  ? 13  VAL A HG13 1 
ATOM   220  H HG21 . VAL A 1 13  ? -7.44976  35.37520 15.99763  1.000 21.92887  ? 13  VAL A HG21 1 
ATOM   221  H HG22 . VAL A 1 13  ? -7.09974  36.91806 15.85421  1.000 21.92887  ? 13  VAL A HG22 1 
ATOM   222  H HG23 . VAL A 1 13  ? -7.15838  36.24731 17.29302  1.000 21.92887  ? 13  VAL A HG23 1 
ATOM   223  N N    . GLU A 1 14  ? -11.29029 38.39921 18.03499  1.000 18.82818  ? 14  GLU A N    1 
ATOM   224  C CA   . GLU A 1 14  ? -12.67801 38.82996 18.16881  1.000 15.19419  ? 14  GLU A CA   1 
ATOM   225  C C    . GLU A 1 14  ? -12.85258 40.26550 17.68640  1.000 18.58103  ? 14  GLU A C    1 
ATOM   226  O O    . GLU A 1 14  ? -13.84446 40.57719 17.02852  1.000 21.32066  ? 14  GLU A O    1 
ATOM   227  C CB   . GLU A 1 14  ? -13.10273 38.74443 19.64468  1.000 20.54568  ? 14  GLU A CB   1 
ATOM   228  C CG   . GLU A 1 14  ? -13.21291 37.30108 20.19916  1.000 18.70872  ? 14  GLU A CG   1 
ATOM   229  C CD   . GLU A 1 14  ? -13.38111 37.28571 21.72921  1.000 23.24769  ? 14  GLU A CD   1 
ATOM   230  O OE1  . GLU A 1 14  ? -14.29884 37.95259 22.24016  1.000 25.88501  ? 14  GLU A OE1  1 
ATOM   231  O OE2  . GLU A 1 14  ? -12.59322 36.60581 22.36398  1.000 18.86865  ? 14  GLU A OE2  1 
ATOM   232  H H    . GLU A 1 14  ? -10.94303 38.07993 18.75407  1.000 22.59381  ? 14  GLU A H    1 
ATOM   233  H HA   . GLU A 1 14  ? -13.24042 38.24480 17.63759  1.000 18.23303  ? 14  GLU A HA   1 
ATOM   234  H HB2  . GLU A 1 14  ? -12.44736 39.21569 20.18256  1.000 24.65481  ? 14  GLU A HB2  1 
ATOM   235  H HB3  . GLU A 1 14  ? -13.97285 39.16231 19.74046  1.000 24.65481  ? 14  GLU A HB3  1 
ATOM   236  H HG2  . GLU A 1 14  ? -13.98438 36.86524 19.80447  1.000 22.45046  ? 14  GLU A HG2  1 
ATOM   237  H HG3  . GLU A 1 14  ? -12.40560 36.81118 19.97748  1.000 22.45046  ? 14  GLU A HG3  1 
ATOM   238  N N    . GLY A 1 15  ? -11.87895 41.11221 17.95429  1.000 18.13550  ? 15  GLY A N    1 
ATOM   239  C CA   . GLY A 1 15  ? -11.97616 42.51315 17.57107  1.000 24.00347  ? 15  GLY A CA   1 
ATOM   240  C C    . GLY A 1 15  ? -11.82990 42.75646 16.08192  1.000 22.84082  ? 15  GLY A C    1 
ATOM   241  O O    . GLY A 1 15  ? -11.93893 43.90497 15.64311  1.000 21.39338  ? 15  GLY A O    1 
ATOM   242  H H    . GLY A 1 15  ? -11.14845 40.90418 18.35764  1.000 21.76260  ? 15  GLY A H    1 
ATOM   243  H HA2  . GLY A 1 15  ? -12.84106 42.85482 17.84694  1.000 28.80417  ? 15  GLY A HA2  1 
ATOM   244  H HA3  . GLY A 1 15  ? -11.27976 43.01213 18.02599  1.000 28.80417  ? 15  GLY A HA3  1 
ATOM   245  N N    . CYS A 1 16  ? -11.60081 41.70687 15.32582  1.000 17.56884  ? 16  CYS A N    1 
ATOM   246  C CA   . CYS A 1 16  ? -11.45478 41.82723 13.87058  1.000 18.50266  ? 16  CYS A CA   1 
ATOM   247  C C    . CYS A 1 16  ? -12.61416 41.23319 13.10446  1.000 21.96459  ? 16  CYS A C    1 
ATOM   248  O O    . CYS A 1 16  ? -12.65048 41.34991 11.87655  1.000 20.06971  ? 16  CYS A O    1 
ATOM   249  C CB   . CYS A 1 16  ? -10.17211 41.14157 13.39390  1.000 20.16376  ? 16  CYS A CB   1 
ATOM   250  S SG   . CYS A 1 16  ? -8.65183  41.72259 14.10558  1.000 22.44054  ? 16  CYS A SG   1 
ATOM   251  H H    . CYS A 1 16  ? -11.52324 40.90333 15.62232  1.000 21.08261  ? 16  CYS A H    1 
ATOM   252  H HA   . CYS A 1 16  ? -11.38968 42.77085 13.65551  1.000 22.20319  ? 16  CYS A HA   1 
ATOM   253  H HB2  . CYS A 1 16  ? -10.24072 40.19661 13.60182  1.000 24.19651  ? 16  CYS A HB2  1 
ATOM   254  H HB3  . CYS A 1 16  ? -10.10293 41.26598 12.43441  1.000 24.19651  ? 16  CYS A HB3  1 
ATOM   255  H HG   . CYS A 1 16  ? -8.65301  42.92259 14.10354  1.000 26.92864  ? 16  CYS A HG   1 
ATOM   256  N N    . MET A 1 17  ? -13.54297 40.55750 13.75580  1.000 15.39864  ? 17  MET A N    1 
ATOM   257  C CA   . MET A 1 17  ? -14.59572 39.85613 13.06948  1.000 17.60826  ? 17  MET A CA   1 
ATOM   258  C C    . MET A 1 17  ? -15.73602 40.80853 12.74644  1.000 22.63662  ? 17  MET A C    1 
ATOM   259  O O    . MET A 1 17  ? -16.15581 41.60462 13.58785  1.000 21.22489  ? 17  MET A O    1 
ATOM   260  C CB   . MET A 1 17  ? -15.09482 38.68021 13.90419  1.000 19.59916  ? 17  MET A CB   1 
ATOM   261  C CG   . MET A 1 17  ? -14.02458 37.67130 14.21938  1.000 17.49169  ? 17  MET A CG   1 
ATOM   262  S SD   . MET A 1 17  ? -13.07095 37.06796 12.81653  1.000 20.15635  ? 17  MET A SD   1 
ATOM   263  C CE   . MET A 1 17  ? -14.32823 36.46447 11.67629  1.000 22.18400  ? 17  MET A CE   1 
ATOM   264  H H    . MET A 1 17  ? -13.58211 40.49150 14.61237  1.000 18.47837  ? 17  MET A H    1 
ATOM   265  H HA   . MET A 1 17  ? -14.24475 39.49545 12.24024  1.000 21.12991  ? 17  MET A HA   1 
ATOM   266  H HB2  . MET A 1 17  ? -15.44156 39.01812 14.74472  1.000 23.51899  ? 17  MET A HB2  1 
ATOM   267  H HB3  . MET A 1 17  ? -15.79752 38.22494 13.41446  1.000 23.51899  ? 17  MET A HB3  1 
ATOM   268  H HG2  . MET A 1 17  ? -13.39753 38.07728 14.83816  1.000 20.99003  ? 17  MET A HG2  1 
ATOM   269  H HG3  . MET A 1 17  ? -14.44572 36.90083 14.63158  1.000 20.99003  ? 17  MET A HG3  1 
ATOM   270  H HE1  . MET A 1 17  ? -15.06141 37.09902 11.64996  1.000 26.62079  ? 17  MET A HE1  1 
ATOM   271  H HE2  . MET A 1 17  ? -13.93678 36.37450 10.79336  1.000 26.62079  ? 17  MET A HE2  1 
ATOM   272  H HE3  . MET A 1 17  ? -14.64773 35.60251 11.98587  1.000 26.62079  ? 17  MET A HE3  1 
ATOM   273  N N    . VAL A 1 18  ? -16.21421 40.73180 11.51070  1.000 17.09589  ? 18  VAL A N    1 
ATOM   274  C CA   . VAL A 1 18  ? -17.34914 41.49188 11.02280  1.000 19.82741  ? 18  VAL A CA   1 
ATOM   275  C C    . VAL A 1 18  ? -18.28194 40.57575 10.23276  1.000 20.74469  ? 18  VAL A C    1 
ATOM   276  O O    . VAL A 1 18  ? -17.94921 39.44918 9.86333   1.000 17.37290  ? 18  VAL A O    1 
ATOM   277  C CB   . VAL A 1 18  ? -16.90227 42.69874 10.13779  1.000 18.15481  ? 18  VAL A CB   1 
ATOM   278  C CG1  . VAL A 1 18  ? -15.98553 43.62662 10.86597  1.000 20.96952  ? 18  VAL A CG1  1 
ATOM   279  C CG2  . VAL A 1 18  ? -16.22477 42.20259 8.86024   1.000 20.51358  ? 18  VAL A CG2  1 
ATOM   280  H H    . VAL A 1 18  ? -15.87812 40.21875 10.90786  1.000 20.51507  ? 18  VAL A H    1 
ATOM   281  H HA   . VAL A 1 18  ? -17.84669 41.82480 11.78603  1.000 23.79289  ? 18  VAL A HA   1 
ATOM   282  H HB   . VAL A 1 18  ? -17.70076 43.19874 9.90688   1.000 21.78577  ? 18  VAL A HB   1 
ATOM   283  H HG11 . VAL A 1 18  ? -15.84712 44.42120 10.32709  1.000 25.16343  ? 18  VAL A HG11 1 
ATOM   284  H HG12 . VAL A 1 18  ? -16.38934 43.86838 11.71414  1.000 25.16343  ? 18  VAL A HG12 1 
ATOM   285  H HG13 . VAL A 1 18  ? -15.13875 43.17874 11.01849  1.000 25.16343  ? 18  VAL A HG13 1 
ATOM   286  H HG21 . VAL A 1 18  ? -15.83860 42.95987 8.39302   1.000 24.61630  ? 18  VAL A HG21 1 
ATOM   287  H HG22 . VAL A 1 18  ? -15.52859 41.57005 9.09718   1.000 24.61630  ? 18  VAL A HG22 1 
ATOM   288  H HG23 . VAL A 1 18  ? -16.88729 41.77038 8.29885   1.000 24.61630  ? 18  VAL A HG23 1 
ATOM   289  N N    . GLN A 1 19  ? -19.48512 41.08034 9.95418   1.000 20.27983  ? 19  GLN A N    1 
ATOM   290  C CA   . GLN A 1 19  ? -20.44412 40.39645 9.12334   1.000 20.70971  ? 19  GLN A CA   1 
ATOM   291  C C    . GLN A 1 19  ? -20.41033 40.97832 7.71295   1.000 19.30322  ? 19  GLN A C    1 
ATOM   292  O O    . GLN A 1 19  ? -20.30088 42.19658 7.54153   1.000 20.34322  ? 19  GLN A O    1 
ATOM   293  C CB   . GLN A 1 19  ? -21.85453 40.58465 9.68616   1.000 22.19264  ? 19  GLN A CB   1 
ATOM   294  C CG   . GLN A 1 19  ? -22.92003 39.92531 8.86584   1.000 27.25519  ? 19  GLN A CG   1 
ATOM   295  C CD   . GLN A 1 19  ? -24.29083 40.24693 9.38708   1.000 32.93485  ? 19  GLN A CD   1 
ATOM   296  O OE1  . GLN A 1 19  ? -24.81081 41.34104 9.13678   1.000 35.54273  ? 19  GLN A OE1  1 
ATOM   297  N NE2  . GLN A 1 19  ? -24.87204 39.32528 10.13682  1.000 30.08372  ? 19  GLN A NE2  1 
ATOM   298  H H    . GLN A 1 19  ? -19.76561 41.83829 10.24816  1.000 24.33579  ? 19  GLN A H    1 
ATOM   299  H HA   . GLN A 1 19  ? -20.22823 39.45147 9.08726   1.000 24.85165  ? 19  GLN A HA   1 
ATOM   300  H HB2  . GLN A 1 19  ? -21.88843 40.20433 10.57785  1.000 26.63117  ? 19  GLN A HB2  1 
ATOM   301  H HB3  . GLN A 1 19  ? -22.05240 41.53356 9.72246   1.000 26.63117  ? 19  GLN A HB3  1 
ATOM   302  H HG2  . GLN A 1 19  ? -22.86013 40.23857 7.94977   1.000 32.70623  ? 19  GLN A HG2  1 
ATOM   303  H HG3  . GLN A 1 19  ? -22.79952 38.96330 8.89605   1.000 32.70623  ? 19  GLN A HG3  1 
ATOM   304  H HE21 . GLN A 1 19  ? -24.46443 38.58652 10.30323  1.000 36.10046  ? 19  GLN A HE21 1 
ATOM   305  H HE22 . GLN A 1 19  ? -25.65756 39.46477 10.45790  1.000 36.10046  ? 19  GLN A HE22 1 
ATOM   306  N N    . VAL A 1 20  ? -20.46264 40.10015 6.72221   1.000 19.54336  ? 20  VAL A N    1 
ATOM   307  C CA   . VAL A 1 20  ? -20.51426 40.51560 5.31694   1.000 23.35892  ? 20  VAL A CA   1 
ATOM   308  C C    . VAL A 1 20  ? -21.74768 39.89269 4.69491   1.000 21.71294  ? 20  VAL A C    1 
ATOM   309  O O    . VAL A 1 20  ? -21.92877 38.66465 4.73082   1.000 20.14639  ? 20  VAL A O    1 
ATOM   310  C CB   . VAL A 1 20  ? -19.25417 40.10706 4.53764   1.000 20.30421  ? 20  VAL A CB   1 
ATOM   311  C CG1  . VAL A 1 20  ? -19.40276 40.63536 3.07896   1.000 21.72948  ? 20  VAL A CG1  1 
ATOM   312  C CG2  . VAL A 1 20  ? -18.01369 40.68091 5.10674   1.000 18.82763  ? 20  VAL A CG2  1 
ATOM   313  H H    . VAL A 1 20  ? -20.46963 39.24757 6.83472   1.000 23.45204  ? 20  VAL A H    1 
ATOM   314  H HA   . VAL A 1 20  ? -20.59468 41.48149 5.27852   1.000 28.03071  ? 20  VAL A HA   1 
ATOM   315  H HB   . VAL A 1 20  ? -19.17357 39.14123 4.57750   1.000 24.36505  ? 20  VAL A HB   1 
ATOM   316  H HG11 . VAL A 1 20  ? -20.10382 41.30533 3.05561   1.000 26.07537  ? 20  VAL A HG11 1 
ATOM   317  H HG12 . VAL A 1 20  ? -18.56119 41.02728 2.79776   1.000 26.07537  ? 20  VAL A HG12 1 
ATOM   318  H HG13 . VAL A 1 20  ? -19.63358 39.89463 2.49678   1.000 26.07537  ? 20  VAL A HG13 1 
ATOM   319  H HG21 . VAL A 1 20  ? -17.24904 40.29018 4.65558   1.000 22.59315  ? 20  VAL A HG21 1 
ATOM   320  H HG22 . VAL A 1 20  ? -18.02049 41.64179 4.97423   1.000 22.59315  ? 20  VAL A HG22 1 
ATOM   321  H HG23 . VAL A 1 20  ? -17.97775 40.47796 6.05459   1.000 22.59315  ? 20  VAL A HG23 1 
ATOM   322  N N    . ILE A 1 21  ? -22.60781 40.73466 4.09609   1.000 24.33195  ? 21  ILE A N    1 
ATOM   323  C CA   . ILE A 1 21  ? -23.78799 40.27973 3.38055   1.000 19.90096  ? 21  ILE A CA   1 
ATOM   324  C C    . ILE A 1 21  ? -23.68084 40.71325 1.91805   1.000 19.68367  ? 21  ILE A C    1 
ATOM   325  O O    . ILE A 1 21  ? -23.35166 41.86955 1.63117   1.000 27.57011  ? 21  ILE A O    1 
ATOM   326  C CB   . ILE A 1 21  ? -25.08004 40.87158 3.99284   1.000 26.61626  ? 21  ILE A CB   1 
ATOM   327  C CG1  . ILE A 1 21  ? -25.30325 40.32754 5.40996   1.000 31.32354  ? 21  ILE A CG1  1 
ATOM   328  C CG2  . ILE A 1 21  ? -26.26395 40.54379 3.10390   1.000 30.97075  ? 21  ILE A CG2  1 
ATOM   329  C CD1  . ILE A 1 21  ? -26.43201 41.03842 6.15652   1.000 31.75802  ? 21  ILE A CD1  1 
ATOM   330  H H    . ILE A 1 21  ? -22.51691 41.58984 4.09718   1.000 29.19834  ? 21  ILE A H    1 
ATOM   331  H HA   . ILE A 1 21  ? -23.81807 39.31101 3.42036   1.000 23.88115  ? 21  ILE A HA   1 
ATOM   332  N N    . CYS A 1 22  ? -23.95960 39.79511 1.02556   1.000 24.85791  ? 22  CYS A N    1 
ATOM   333  C CA   . CYS A 1 22  ? -24.12890 40.10907 -0.38624  1.000 25.17955  ? 22  CYS A CA   1 
ATOM   334  C C    . CYS A 1 22  ? -25.34652 39.33395 -0.85629  1.000 34.61315  ? 22  CYS A C    1 
ATOM   335  O O    . CYS A 1 22  ? -25.36814 38.09802 -0.78884  1.000 30.67269  ? 22  CYS A O    1 
ATOM   336  C CB   . CYS A 1 22  ? -22.87481 39.73022 -1.17461  1.000 21.26621  ? 22  CYS A CB   1 
ATOM   337  S SG   . CYS A 1 22  ? -22.89909 40.26348 -2.87939  1.000 30.43980  ? 22  CYS A SG   1 
ATOM   338  H H    . CYS A 1 22  ? -24.05966 38.96086 1.20892   1.000 29.82950  ? 22  CYS A H    1 
ATOM   339  H HA   . CYS A 1 22  ? -24.28487 41.05584 -0.52839  1.000 30.21547  ? 22  CYS A HA   1 
ATOM   340  H HB2  . CYS A 1 22  ? -22.10488 40.13842 -0.74862  1.000 25.51945  ? 22  CYS A HB2  1 
ATOM   341  H HB3  . CYS A 1 22  ? -22.78402 38.76449 -1.16872  1.000 25.51945  ? 22  CYS A HB3  1 
ATOM   342  H HG   . CYS A 1 22  ? -21.82565 40.04914 -3.37112  1.000 36.52776  ? 22  CYS A HG   1 
ATOM   343  N N    . GLY A 1 23  ? -26.36788 40.06040 -1.30407  1.000 37.12264  ? 23  GLY A N    1 
ATOM   344  C CA   . GLY A 1 23  ? -27.62113 39.41284 -1.68240  1.000 43.87349  ? 23  GLY A CA   1 
ATOM   345  C C    . GLY A 1 23  ? -28.28372 38.77369 -0.47589  1.000 32.46210  ? 23  GLY A C    1 
ATOM   346  O O    . GLY A 1 23  ? -28.58454 39.43511 0.52649   1.000 40.78509  ? 23  GLY A O    1 
ATOM   347  H H    . GLY A 1 23  ? -26.36226 40.91533 -1.39711  1.000 44.54717  ? 23  GLY A H    1 
ATOM   348  H HA2  . GLY A 1 23  ? -28.22772 40.06867 -2.06034  1.000 52.64819  ? 23  GLY A HA2  1 
ATOM   349  H HA3  . GLY A 1 23  ? -27.44778 38.72489 -2.34390  1.000 52.64819  ? 23  GLY A HA3  1 
ATOM   350  N N    . THR A 1 24  ? -28.52176 37.46943 -0.55735  1.000 34.56023  ? 24  THR A N    1 
ATOM   351  C CA   . THR A 1 24  ? -29.09373 36.71513 0.55432   1.000 44.56978  ? 24  THR A CA   1 
ATOM   352  C C    . THR A 1 24  ? -28.06498 35.87254 1.29838   1.000 40.17875  ? 24  THR A C    1 
ATOM   353  O O    . THR A 1 24  ? -28.43459 35.14180 2.21520   1.000 40.19835  ? 24  THR A O    1 
ATOM   354  C CB   . THR A 1 24  ? -30.21289 35.80410 0.04450   1.000 52.01909  ? 24  THR A CB   1 
ATOM   355  O OG1  . THR A 1 24  ? -29.72209 34.99364 -1.03561  1.000 50.31378  ? 24  THR A OG1  1 
ATOM   356  C CG2  . THR A 1 24  ? -31.39481 36.64203 -0.43125  1.000 55.22872  ? 24  THR A CG2  1 
ATOM   357  H H    . THR A 1 24  ? -28.35878 36.99255 -1.25421  1.000 41.47228  ? 24  THR A H    1 
ATOM   358  H HA   . THR A 1 24  ? -29.47429 37.34529 1.18596   1.000 53.48374  ? 24  THR A HA   1 
ATOM   359  H HB   . THR A 1 24  ? -30.51803 35.22385 0.75942   1.000 62.42291  ? 24  THR A HB   1 
ATOM   360  H HG1  . THR A 1 24  ? -29.21097 34.39718 -0.73797  1.000 60.37654  ? 24  THR A HG1  1 
ATOM   361  H HG21 . THR A 1 24  ? -32.16219 36.07130 -0.59343  1.000 66.27446  ? 24  THR A HG21 1 
ATOM   362  H HG22 . THR A 1 24  ? -31.62821 37.29932 0.24284   1.000 66.27446  ? 24  THR A HG22 1 
ATOM   363  H HG23 . THR A 1 24  ? -31.16545 37.10236 -1.25368  1.000 66.27446  ? 24  THR A HG23 1 
ATOM   364  N N    . THR A 1 25  ? -26.79318 35.95955 0.92977   1.000 35.57106  ? 25  THR A N    1 
ATOM   365  C CA   . THR A 1 25  ? -25.74101 35.19441 1.58502   1.000 35.38821  ? 25  THR A CA   1 
ATOM   366  C C    . THR A 1 25  ? -25.13917 36.03562 2.69592   1.000 29.12969  ? 25  THR A C    1 
ATOM   367  O O    . THR A 1 25  ? -24.74978 37.19647 2.48702   1.000 26.62325  ? 25  THR A O    1 
ATOM   368  C CB   . THR A 1 25  ? -24.67305 34.78569 0.57077   1.000 35.02572  ? 25  THR A CB   1 
ATOM   369  O OG1  . THR A 1 25  ? -25.25510 33.92576 -0.41123  1.000 40.26683  ? 25  THR A OG1  1 
ATOM   370  C CG2  . THR A 1 25  ? -23.51622 34.04344 1.23966   1.000 30.11133  ? 25  THR A CG2  1 
ATOM   371  H H    . THR A 1 25  ? -26.50986 36.46286 0.29257   1.000 42.68527  ? 25  THR A H    1 
ATOM   372  H HA   . THR A 1 25  ? -26.10427 34.38431 1.97576   1.000 42.46585  ? 25  THR A HA   1 
ATOM   373  H HB   . THR A 1 25  ? -24.31872 35.58710 0.15474   1.000 42.03087  ? 25  THR A HB   1 
ATOM   374  H HG1  . THR A 1 25  ? -24.87954 34.04181 -1.15358  1.000 48.32020  ? 25  THR A HG1  1 
ATOM   375  H HG21 . THR A 1 25  ? -22.95383 33.62984 0.56620   1.000 36.13359  ? 25  THR A HG21 1 
ATOM   376  H HG22 . THR A 1 25  ? -22.98087 34.66312 1.75957   1.000 36.13359  ? 25  THR A HG22 1 
ATOM   377  H HG23 . THR A 1 25  ? -23.86075 33.35410 1.82873   1.000 36.13359  ? 25  THR A HG23 1 
ATOM   378  N N    . THR A 1 26  ? -25.08315 35.45930 3.89454   1.000 26.95534  ? 26  THR A N    1 
ATOM   379  C CA   . THR A 1 26  ? -24.43585 36.08809 5.03978   1.000 27.76106  ? 26  THR A CA   1 
ATOM   380  C C    . THR A 1 26  ? -23.27326 35.20712 5.49823   1.000 22.99343  ? 26  THR A C    1 
ATOM   381  O O    . THR A 1 26  ? -23.43016 33.98522 5.62692   1.000 26.65877  ? 26  THR A O    1 
ATOM   382  C CB   . THR A 1 26  ? -25.43268 36.26419 6.19758   1.000 34.17350  ? 26  THR A CB   1 
ATOM   383  O OG1  . THR A 1 26  ? -26.52521 37.07398 5.75123   1.000 37.22703  ? 26  THR A OG1  1 
ATOM   384  C CG2  . THR A 1 26  ? -24.77733 36.93272 7.39864   1.000 26.52875  ? 26  THR A CG2  1 
ATOM   385  H H    . THR A 1 26  ? -25.42049 34.68810 4.07076   1.000 32.34641  ? 26  THR A H    1 
ATOM   386  H HA   . THR A 1 26  ? -24.09098 36.95794 4.78417   1.000 33.31328  ? 26  THR A HA   1 
ATOM   387  H HB   . THR A 1 26  ? -25.75087 35.39260 6.48037   1.000 41.00820  ? 26  THR A HB   1 
ATOM   388  H HG1  . THR A 1 26  ? -26.24650 37.83379 5.52624   1.000 44.67243  ? 26  THR A HG1  1 
ATOM   389  H HG21 . THR A 1 26  ? -24.05240 36.38057 7.73106   1.000 31.83450  ? 26  THR A HG21 1 
ATOM   390  H HG22 . THR A 1 26  ? -24.42211 37.79853 7.14353   1.000 31.83450  ? 26  THR A HG22 1 
ATOM   391  H HG23 . THR A 1 26  ? -25.42917 37.05599 8.10633   1.000 31.83450  ? 26  THR A HG23 1 
ATOM   392  N N    . LEU A 1 27  ? -22.11706 35.82586 5.70264   1.000 23.88346  ? 27  LEU A N    1 
ATOM   393  C CA   . LEU A 1 27  ? -20.96710 35.11715 6.29505   1.000 21.38761  ? 27  LEU A CA   1 
ATOM   394  C C    . LEU A 1 27  ? -20.09927 36.13074 7.03235   1.000 19.49462  ? 27  LEU A C    1 
ATOM   395  O O    . LEU A 1 27  ? -20.49694 37.28431 7.27185   1.000 20.70050  ? 27  LEU A O    1 
ATOM   396  C CB   . LEU A 1 27  ? -20.26185 34.24601 5.24425   1.000 18.83351  ? 27  LEU A CB   1 
ATOM   397  C CG   . LEU A 1 27  ? -19.89456 34.87257 3.90123   1.000 20.20333  ? 27  LEU A CG   1 
ATOM   398  C CD1  . LEU A 1 27  ? -18.94777 36.02005 4.03413   1.000 19.33973  ? 27  LEU A CD1  1 
ATOM   399  C CD2  . LEU A 1 27  ? -19.26999 33.80205 2.98502   1.000 20.51397  ? 27  LEU A CD2  1 
ATOM   400  H H    . LEU A 1 27  ? -21.96569 36.65043 5.51090   1.000 28.66016  ? 27  LEU A H    1 
ATOM   401  H HA   . LEU A 1 27  ? -21.27282 34.49962 6.97776   1.000 25.66513  ? 27  LEU A HA   1 
ATOM   402  H HB2  . LEU A 1 27  ? -19.43323 33.92894 5.63638   1.000 22.60021  ? 27  LEU A HB2  1 
ATOM   403  H HB3  . LEU A 1 27  ? -20.84457 33.49572 5.04830   1.000 22.60021  ? 27  LEU A HB3  1 
ATOM   404  H HG   . LEU A 1 27  ? -20.71005 35.22170 3.50880   1.000 24.24400  ? 27  LEU A HG   1 
ATOM   405  H HD11 . LEU A 1 27  ? -18.74070 36.36259 3.15057   1.000 23.20768  ? 27  LEU A HD11 1 
ATOM   406  H HD12 . LEU A 1 27  ? -19.36529 36.71373 4.56835   1.000 23.20768  ? 27  LEU A HD12 1 
ATOM   407  H HD13 . LEU A 1 27  ? -18.13674 35.71169 4.46779   1.000 23.20768  ? 27  LEU A HD13 1 
ATOM   408  H HD21 . LEU A 1 27  ? -18.40575 34.11599 2.67610   1.000 24.61676  ? 27  LEU A HD21 1 
ATOM   409  H HD22 . LEU A 1 27  ? -19.16272 32.97956 3.48792   1.000 24.61676  ? 27  LEU A HD22 1 
ATOM   410  H HD23 . LEU A 1 27  ? -19.85759 33.65257 2.22787   1.000 24.61676  ? 27  LEU A HD23 1 
ATOM   411  N N    . ASN A 1 28  ? -18.91583 35.70308 7.44298   1.000 16.93280  ? 28  ASN A N    1 
ATOM   412  C CA   . ASN A 1 28  ? -18.06383 36.51578 8.27217   1.000 15.85234  ? 28  ASN A CA   1 
ATOM   413  C C    . ASN A 1 28  ? -16.91113 37.03999 7.46500   1.000 14.83731  ? 28  ASN A C    1 
ATOM   414  O O    . ASN A 1 28  ? -16.50709 36.41838 6.47404   1.000 16.28413  ? 28  ASN A O    1 
ATOM   415  C CB   . ASN A 1 28  ? -17.48787 35.69696 9.46429   1.000 16.19376  ? 28  ASN A CB   1 
ATOM   416  C CG   . ASN A 1 28  ? -18.58321 35.00176 10.25989  1.000 16.61661  ? 28  ASN A CG   1 
ATOM   417  O OD1  . ASN A 1 28  ? -19.26241 35.62964 11.06459  1.000 19.12925  ? 28  ASN A OD1  1 
ATOM   418  N ND2  . ASN A 1 28  ? -18.77326 33.72502 10.02042  1.000 17.81638  ? 28  ASN A ND2  1 
ATOM   419  H H    . ASN A 1 28  ? -18.58582 34.93330 7.24772   1.000 20.31935  ? 28  ASN A H    1 
ATOM   420  H HA   . ASN A 1 28  ? -18.58174 37.25920 8.61858   1.000 19.02281  ? 28  ASN A HA   1 
ATOM   421  H HB2  . ASN A 1 28  ? -16.88385 35.01885 9.12335   1.000 19.43251  ? 28  ASN A HB2  1 
ATOM   422  H HB3  . ASN A 1 28  ? -17.01210 36.29490 10.06179  1.000 19.43251  ? 28  ASN A HB3  1 
ATOM   423  H HD21 . ASN A 1 28  ? -19.38202 33.29332 10.44779  1.000 21.37965  ? 28  ASN A HD21 1 
ATOM   424  H HD22 . ASN A 1 28  ? -18.28900 33.32036 9.43618   1.000 21.37965  ? 28  ASN A HD22 1 
ATOM   425  N N    . GLY A 1 29  ? -16.39078 38.19198 7.88536   1.000 17.12780  ? 29  GLY A N    1 
ATOM   426  C CA   . GLY A 1 29  ? -15.15096 38.70712 7.34873   1.000 17.18587  ? 29  GLY A CA   1 
ATOM   427  C C    . GLY A 1 29  ? -14.16510 39.09204 8.44040   1.000 16.43706  ? 29  GLY A C    1 
ATOM   428  O O    . GLY A 1 29  ? -14.52412 39.20184 9.62503   1.000 16.61565  ? 29  GLY A O    1 
ATOM   429  H H    . GLY A 1 29  ? -16.74642 38.69315 8.48699   1.000 20.55335  ? 29  GLY A H    1 
ATOM   430  H HA2  . GLY A 1 29  ? -14.73784 38.03186 6.78815   1.000 20.62305  ? 29  GLY A HA2  1 
ATOM   431  H HA3  . GLY A 1 29  ? -15.33498 39.49382 6.81193   1.000 20.62305  ? 29  GLY A HA3  1 
ATOM   432  N N    . LEU A 1 30  ? -12.92815 39.27150 8.04803   1.000 15.74789  ? 30  LEU A N    1 
ATOM   433  C CA   . LEU A 1 30  ? -11.81473 39.63844 8.90944   1.000 17.04632  ? 30  LEU A CA   1 
ATOM   434  C C    . LEU A 1 30  ? -11.34834 41.04576 8.55035   1.000 15.70447  ? 30  LEU A C    1 
ATOM   435  O O    . LEU A 1 30  ? -10.88633 41.29529 7.42488   1.000 17.34951  ? 30  LEU A O    1 
ATOM   436  C CB   . LEU A 1 30  ? -10.68399 38.62780 8.75456   1.000 14.99815  ? 30  LEU A CB   1 
ATOM   437  C CG   . LEU A 1 30  ? -9.43745  38.80327 9.58361   1.000 17.46219  ? 30  LEU A CG   1 
ATOM   438  C CD1  . LEU A 1 30  ? -9.77602  38.45929 11.02703  1.000 18.71672  ? 30  LEU A CD1  1 
ATOM   439  C CD2  . LEU A 1 30  ? -8.32621  37.91830 9.05736   1.000 18.04592  ? 30  LEU A CD2  1 
ATOM   440  H H    . LEU A 1 30  ? -12.68305 39.18163 7.22861   1.000 18.89747  ? 30  LEU A H    1 
ATOM   441  H HA   . LEU A 1 30  ? -12.09825 39.65187 9.83699   1.000 20.45559  ? 30  LEU A HA   1 
ATOM   442  H HB2  . LEU A 1 30  ? -11.04152 37.75380 8.97637   1.000 17.99778  ? 30  LEU A HB2  1 
ATOM   443  H HB3  . LEU A 1 30  ? -10.40227 38.64524 7.82653   1.000 17.99778  ? 30  LEU A HB3  1 
ATOM   444  H HG   . LEU A 1 30  ? -9.11769  39.71795 9.53886   1.000 20.95463  ? 30  LEU A HG   1 
ATOM   445  H HD11 . LEU A 1 30  ? -8.95489  38.41117 11.54116  1.000 22.46006  ? 30  LEU A HD11 1 
ATOM   446  H HD12 . LEU A 1 30  ? -10.35308 39.14975 11.38921  1.000 22.46006  ? 30  LEU A HD12 1 
ATOM   447  H HD13 . LEU A 1 30  ? -10.23086 37.60282 11.04923  1.000 22.46006  ? 30  LEU A HD13 1 
ATOM   448  H HD21 . LEU A 1 30  ? -7.50860  38.11747 9.53981   1.000 21.65510  ? 30  LEU A HD21 1 
ATOM   449  H HD22 . LEU A 1 30  ? -8.57169  36.98955 9.19173   1.000 21.65510  ? 30  LEU A HD22 1 
ATOM   450  H HD23 . LEU A 1 30  ? -8.20338  38.09444 8.11143   1.000 21.65510  ? 30  LEU A HD23 1 
ATOM   451  N N    . TRP A 1 31  ? -11.48585 41.96866 9.47463   1.000 17.03890  ? 31  TRP A N    1 
ATOM   452  C CA   . TRP A 1 31  ? -11.25307 43.40040 9.25799   1.000 16.58188  ? 31  TRP A CA   1 
ATOM   453  C C    . TRP A 1 31  ? -9.90047  43.77336 9.84665   1.000 19.86367  ? 31  TRP A C    1 
ATOM   454  O O    . TRP A 1 31  ? -9.72204  43.78784 11.07592  1.000 18.24967  ? 31  TRP A O    1 
ATOM   455  C CB   . TRP A 1 31  ? -12.39550 44.16355 9.92627   1.000 16.89584  ? 31  TRP A CB   1 
ATOM   456  C CG   . TRP A 1 31  ? -12.35464 45.65099 9.79679   1.000 23.27970  ? 31  TRP A CG   1 
ATOM   457  C CD1  . TRP A 1 31  ? -11.70809 46.39268 8.83491   1.000 20.66342  ? 31  TRP A CD1  1 
ATOM   458  C CD2  . TRP A 1 31  ? -12.99432 46.60390 10.67051  1.000 20.88297  ? 31  TRP A CD2  1 
ATOM   459  N NE1  . TRP A 1 31  ? -11.91743 47.73386 9.06157   1.000 25.09286  ? 31  TRP A NE1  1 
ATOM   460  C CE2  . TRP A 1 31  ? -12.69495 47.89507 10.17535  1.000 25.72275  ? 31  TRP A CE2  1 
ATOM   461  C CE3  . TRP A 1 31  ? -13.78555 46.48341 11.81819  1.000 25.52698  ? 31  TRP A CE3  1 
ATOM   462  C CZ2  . TRP A 1 31  ? -13.14114 49.06212 10.80483  1.000 27.07330  ? 31  TRP A CZ2  1 
ATOM   463  C CZ3  . TRP A 1 31  ? -14.23821 47.64308 12.45021  1.000 27.02500  ? 31  TRP A CZ3  1 
ATOM   464  C CH2  . TRP A 1 31  ? -13.91934 48.91482 11.92145  1.000 25.92175  ? 31  TRP A CH2  1 
ATOM   465  H H    . TRP A 1 31  ? -11.72534 41.79316 10.28174  1.000 20.44668  ? 31  TRP A H    1 
ATOM   466  H HA   . TRP A 1 31  ? -11.21611 43.61656 8.31310   1.000 19.89825  ? 31  TRP A HA   1 
ATOM   467  H HB2  . TRP A 1 31  ? -13.23035 43.86490 9.53293   1.000 20.27501  ? 31  TRP A HB2  1 
ATOM   468  H HB3  . TRP A 1 31  ? -12.38328 43.95839 10.87424  1.000 20.27501  ? 31  TRP A HB3  1 
ATOM   469  H HD1  . TRP A 1 31  ? -11.20511 46.04049 8.13643   1.000 24.79611  ? 31  TRP A HD1  1 
ATOM   470  H HE1  . TRP A 1 31  ? -11.60688 48.37291 8.57704   1.000 30.11144  ? 31  TRP A HE1  1 
ATOM   471  H HE3  . TRP A 1 31  ? -14.00625 45.64487 12.15439  1.000 30.63238  ? 31  TRP A HE3  1 
ATOM   472  H HZ2  . TRP A 1 31  ? -12.91814 49.90376 10.47799  1.000 32.48797  ? 31  TRP A HZ2  1 
ATOM   473  H HZ3  . TRP A 1 31  ? -14.75196 47.57865 13.22274  1.000 32.43001  ? 31  TRP A HZ3  1 
ATOM   474  H HH2  . TRP A 1 31  ? -14.24828 49.67457 12.34511  1.000 31.10610  ? 31  TRP A HH2  1 
ATOM   475  N N    . LEU A 1 32  ? -8.91830  44.01273 8.97573   1.000 19.10860  ? 32  LEU A N    1 
ATOM   476  C CA   . LEU A 1 32  ? -7.58914  44.35946 9.36242   1.000 17.07472  ? 32  LEU A CA   1 
ATOM   477  C C    . LEU A 1 32  ? -7.23008  45.65650 8.64660   1.000 22.51391  ? 32  LEU A C    1 
ATOM   478  O O    . LEU A 1 32  ? -7.33091  45.73599 7.41821   1.000 20.03767  ? 32  LEU A O    1 
ATOM   479  C CB   . LEU A 1 32  ? -6.56549  43.28224 8.99026   1.000 21.96456  ? 32  LEU A CB   1 
ATOM   480  C CG   . LEU A 1 32  ? -6.72323  41.89176 9.62895   1.000 18.38672  ? 32  LEU A CG   1 
ATOM   481  C CD1  . LEU A 1 32  ? -5.80320  40.89036 8.95160   1.000 20.56407  ? 32  LEU A CD1  1 
ATOM   482  C CD2  . LEU A 1 32  ? -6.43159  41.95817 11.13133  1.000 18.67242  ? 32  LEU A CD2  1 
ATOM   483  H H    . LEU A 1 32  ? -9.02084  43.97398 8.12274   1.000 22.93032  ? 32  LEU A H    1 
ATOM   484  H HA   . LEU A 1 32  ? -7.55531  44.47510 10.32491  1.000 20.48967  ? 32  LEU A HA   1 
ATOM   485  H HB2  . LEU A 1 32  ? -6.60691  43.15479 8.02956   1.000 26.35747  ? 32  LEU A HB2  1 
ATOM   486  H HB3  . LEU A 1 32  ? -5.68796  43.60843 9.24412   1.000 26.35747  ? 32  LEU A HB3  1 
ATOM   487  H HG   . LEU A 1 32  ? -7.63746  41.58957 9.51160   1.000 22.06406  ? 32  LEU A HG   1 
ATOM   488  H HD11 . LEU A 1 32  ? -5.78877  40.07219 9.47246   1.000 24.67688  ? 32  LEU A HD11 1 
ATOM   489  H HD12 . LEU A 1 32  ? -6.13677  40.70846 8.05911   1.000 24.67688  ? 32  LEU A HD12 1 
ATOM   490  H HD13 . LEU A 1 32  ? -4.91030  41.26594 8.90083   1.000 24.67688  ? 32  LEU A HD13 1 
ATOM   491  H HD21 . LEU A 1 32  ? -6.50154  41.06633 11.50633  1.000 22.40690  ? 32  LEU A HD21 1 
ATOM   492  H HD22 . LEU A 1 32  ? -5.53486  42.30340 11.26400  1.000 22.40690  ? 32  LEU A HD22 1 
ATOM   493  H HD23 . LEU A 1 32  ? -7.07801  42.54587 11.55283  1.000 22.40690  ? 32  LEU A HD23 1 
ATOM   494  N N    . ASP A 1 33  ? -6.79908  46.65958 9.39841   1.000 20.94230  ? 33  ASP A N    1 
ATOM   495  C CA   . ASP A 1 33  ? -6.57424  48.00739 8.79429   1.000 20.83950  ? 33  ASP A CA   1 
ATOM   496  C C    . ASP A 1 33  ? -7.86065  48.35488 8.04351   1.000 20.56105  ? 33  ASP A C    1 
ATOM   497  O O    . ASP A 1 33  ? -8.95330  48.18535 8.59616   1.000 23.74026  ? 33  ASP A O    1 
ATOM   498  C CB   . ASP A 1 33  ? -5.29064  48.04189 7.99629   1.000 25.64975  ? 33  ASP A CB   1 
ATOM   499  C CG   . ASP A 1 33  ? -4.08706  47.65356 8.82292   1.000 34.95643  ? 33  ASP A CG   1 
ATOM   500  O OD1  . ASP A 1 33  ? -3.96752  48.16958 9.94998   1.000 38.40921  ? 33  ASP A OD1  1 
ATOM   501  O OD2  . ASP A 1 33  ? -3.27442  46.82635 8.35249   1.000 45.39678  ? 33  ASP A OD2  1 
ATOM   502  H H    . ASP A 1 33  ? -6.62906  46.60457 10.23963  1.000 25.13077  ? 33  ASP A H    1 
ATOM   503  H HA   . ASP A 1 33  ? -6.45596  48.65715 9.50473   1.000 25.00740  ? 33  ASP A HA   1 
ATOM   504  H HB2  . ASP A 1 33  ? -5.36077  47.41970 7.25544   1.000 30.77970  ? 33  ASP A HB2  1 
ATOM   505  H HB3  . ASP A 1 33  ? -5.14897  48.94133 7.66188   1.000 30.77970  ? 33  ASP A HB3  1 
ATOM   506  N N    . ASP A 1 34  ? -7.79544  48.82019 6.77901   1.000 22.83344  ? 34  ASP A N    1 
ATOM   507  C CA   . ASP A 1 34  ? -8.99250  49.23239 6.05257   1.000 21.75946  ? 34  ASP A CA   1 
ATOM   508  C C    . ASP A 1 34  ? -9.43191  48.21791 5.01452   1.000 24.45345  ? 34  ASP A C    1 
ATOM   509  O O    . ASP A 1 34  ? -10.03974 48.58057 3.99095   1.000 23.82921  ? 34  ASP A O    1 
ATOM   510  C CB   . ASP A 1 34  ? -8.80954  50.62365 5.41715   1.000 23.94154  ? 34  ASP A CB   1 
ATOM   511  C CG   . ASP A 1 34  ? -7.81287  50.61984 4.28149   1.000 32.57535  ? 34  ASP A CG   1 
ATOM   512  O OD1  . ASP A 1 34  ? -6.93431  49.72342 4.22632   1.000 33.11834  ? 34  ASP A OD1  1 
ATOM   513  O OD2  . ASP A 1 34  ? -7.90581  51.52446 3.42364   1.000 43.20108  ? 34  ASP A OD2  1 
ATOM   514  H H    . ASP A 1 34  ? -7.06598  48.90217 6.33093   1.000 27.40012  ? 34  ASP A H    1 
ATOM   515  H HA   . ASP A 1 34  ? -9.71166  49.30771 6.69913   1.000 26.11135  ? 34  ASP A HA   1 
ATOM   516  H HB2  . ASP A 1 34  ? -9.66215  50.92611 5.06719   1.000 28.72985  ? 34  ASP A HB2  1 
ATOM   517  H HB3  . ASP A 1 34  ? -8.49090  51.24107 6.09403   1.000 28.72985  ? 34  ASP A HB3  1 
ATOM   518  N N    . VAL A 1 35  ? -9.19718  46.92507 5.27465   1.000 20.01481  ? 35  VAL A N    1 
ATOM   519  C CA   . VAL A 1 35  ? -9.63327  45.87359 4.35931   1.000 20.32774  ? 35  VAL A CA   1 
ATOM   520  C C    . VAL A 1 35  ? -10.39468 44.81856 5.14618   1.000 18.01123  ? 35  VAL A C    1 
ATOM   521  O O    . VAL A 1 35  ? -10.01853 44.49690 6.28604   1.000 18.21805  ? 35  VAL A O    1 
ATOM   522  C CB   . VAL A 1 35  ? -8.42091  45.22324 3.66614   1.000 24.97181  ? 35  VAL A CB   1 
ATOM   523  C CG1  . VAL A 1 35  ? -8.88315  44.09221 2.77508   1.000 21.15790  ? 35  VAL A CG1  1 
ATOM   524  C CG2  . VAL A 1 35  ? -7.65742  46.25799 2.83716   1.000 26.69965  ? 35  VAL A CG2  1 
ATOM   525  H H    . VAL A 1 35  ? -8.78785  46.63812 5.97445   1.000 24.01777  ? 35  VAL A H    1 
ATOM   526  H HA   . VAL A 1 35  ? -10.22950 46.25227 3.69447   1.000 24.39328  ? 35  VAL A HA   1 
ATOM   527  H HB   . VAL A 1 35  ? -7.82273  44.87028 4.34326   1.000 29.96617  ? 35  VAL A HB   1 
ATOM   528  H HG11 . VAL A 1 35  ? -8.20579  43.92383 2.10148   1.000 25.38948  ? 35  VAL A HG11 1 
ATOM   529  H HG12 . VAL A 1 35  ? -9.01624  43.29816 3.31607   1.000 25.38948  ? 35  VAL A HG12 1 
ATOM   530  H HG13 . VAL A 1 35  ? -9.71700  44.34606 2.34946   1.000 25.38948  ? 35  VAL A HG13 1 
ATOM   531  H HG21 . VAL A 1 35  ? -6.82827  45.86307 2.52501   1.000 32.03958  ? 35  VAL A HG21 1 
ATOM   532  H HG22 . VAL A 1 35  ? -8.20375  46.52166 2.08026   1.000 32.03958  ? 35  VAL A HG22 1 
ATOM   533  H HG23 . VAL A 1 35  ? -7.46748  47.03000 3.39289   1.000 32.03958  ? 35  VAL A HG23 1 
ATOM   534  N N    . VAL A 1 36  ? -11.45353 44.29404 4.54225   1.000 17.34076  ? 36  VAL A N    1 
ATOM   535  C CA   . VAL A 1 36  ? -12.20285 43.15281 5.05401   1.000 16.91939  ? 36  VAL A CA   1 
ATOM   536  C C    . VAL A 1 36  ? -11.96195 41.99942 4.09282   1.000 23.04036  ? 36  VAL A C    1 
ATOM   537  O O    . VAL A 1 36  ? -12.21012 42.12729 2.88439   1.000 18.50766  ? 36  VAL A O    1 
ATOM   538  C CB   . VAL A 1 36  ? -13.70448 43.45455 5.18900   1.000 17.37183  ? 36  VAL A CB   1 
ATOM   539  C CG1  . VAL A 1 36  ? -14.47971 42.22113 5.57114   1.000 19.89818  ? 36  VAL A CG1  1 
ATOM   540  C CG2  . VAL A 1 36  ? -13.92877 44.56937 6.20859   1.000 22.17281  ? 36  VAL A CG2  1 
ATOM   541  H H    . VAL A 1 36  ? -11.77113 44.59518 3.80195   1.000 20.80891  ? 36  VAL A H    1 
ATOM   542  H HA   . VAL A 1 36  ? -11.87104 42.91384 5.93361   1.000 20.30327  ? 36  VAL A HA   1 
ATOM   543  H HB   . VAL A 1 36  ? -14.03725 43.75102 4.32745   1.000 20.84620  ? 36  VAL A HB   1 
ATOM   544  H HG11 . VAL A 1 36  ? -15.37694 42.48057 5.83301   1.000 23.87781  ? 36  VAL A HG11 1 
ATOM   545  H HG12 . VAL A 1 36  ? -14.51765 41.62305 4.80841   1.000 23.87781  ? 36  VAL A HG12 1 
ATOM   546  H HG13 . VAL A 1 36  ? -14.03219 41.78390 6.31240   1.000 23.87781  ? 36  VAL A HG13 1 
ATOM   547  H HG21 . VAL A 1 36  ? -13.58538 44.28364 7.06960   1.000 26.60737  ? 36  VAL A HG21 1 
ATOM   548  H HG22 . VAL A 1 36  ? -13.46057 45.36602 5.91359   1.000 26.60737  ? 36  VAL A HG22 1 
ATOM   549  H HG23 . VAL A 1 36  ? -14.87949 44.74997 6.27504   1.000 26.60737  ? 36  VAL A HG23 1 
ATOM   550  N N    . TYR A 1 37  ? -11.47925 40.89080 4.61703   1.000 17.03822  ? 37  TYR A N    1 
ATOM   551  C CA   . TYR A 1 37  ? -11.23349 39.67397 3.84887   1.000 14.60965  ? 37  TYR A CA   1 
ATOM   552  C C    . TYR A 1 37  ? -12.37191 38.69354 4.07276   1.000 14.33658  ? 37  TYR A C    1 
ATOM   553  O O    . TYR A 1 37  ? -12.81360 38.48681 5.22488   1.000 16.17566  ? 37  TYR A O    1 
ATOM   554  C CB   . TYR A 1 37  ? -9.93075  39.00303 4.30595   1.000 16.18335  ? 37  TYR A CB   1 
ATOM   555  C CG   . TYR A 1 37  ? -8.70751  39.86328 4.21720   1.000 16.93694  ? 37  TYR A CG   1 
ATOM   556  C CD1  . TYR A 1 37  ? -8.40530  40.82735 5.15673   1.000 19.23687  ? 37  TYR A CD1  1 
ATOM   557  C CD2  . TYR A 1 37  ? -7.86352  39.75708 3.08968   1.000 18.77835  ? 37  TYR A CD2  1 
ATOM   558  C CE1  . TYR A 1 37  ? -7.29069  41.64076 5.02428   1.000 21.87728  ? 37  TYR A CE1  1 
ATOM   559  C CE2  . TYR A 1 37  ? -6.75259  40.54383 2.98960   1.000 17.31407  ? 37  TYR A CE2  1 
ATOM   560  C CZ   . TYR A 1 37  ? -6.47774  41.48390 3.96401   1.000 20.33416  ? 37  TYR A CZ   1 
ATOM   561  O OH   . TYR A 1 37  ? -5.35494  42.28615 3.82780   1.000 28.93505  ? 37  TYR A OH   1 
ATOM   562  H H    . TYR A 1 37  ? -11.27598 40.80904 5.44865   1.000 20.44586  ? 37  TYR A H    1 
ATOM   563  H HA   . TYR A 1 37  ? -11.17130 39.89584 2.90664   1.000 17.53158  ? 37  TYR A HA   1 
ATOM   564  H HB2  . TYR A 1 37  ? -10.03187 38.73697 5.23325   1.000 19.42002  ? 37  TYR A HB2  1 
ATOM   565  H HB3  . TYR A 1 37  ? -9.77723  38.22201 3.75157   1.000 19.42002  ? 37  TYR A HB3  1 
ATOM   566  H HD1  . TYR A 1 37  ? -8.96123  40.93375 5.89464   1.000 23.08425  ? 37  TYR A HD1  1 
ATOM   567  H HD2  . TYR A 1 37  ? -8.06501  39.15018 2.41442   1.000 22.53402  ? 37  TYR A HD2  1 
ATOM   568  H HE1  . TYR A 1 37  ? -7.10624  42.29027 5.66383   1.000 26.25274  ? 37  TYR A HE1  1 
ATOM   569  H HE2  . TYR A 1 37  ? -6.17932  40.44683 2.26375   1.000 20.77689  ? 37  TYR A HE2  1 
ATOM   570  H HH   . TYR A 1 37  ? -5.41247  42.95008 4.33916   1.000 34.72206  ? 37  TYR A HH   1 
ATOM   571  N N    . CYS A 1 38  ? -12.87692 38.06863 3.01074   1.000 14.55268  ? 38  CYS A N    1 
ATOM   572  C CA   . CYS A 1 38  ? -13.94525 37.09833 3.17600   1.000 18.46272  ? 38  CYS A CA   1 
ATOM   573  C C    . CYS A 1 38  ? -13.95296 36.11313 2.01822   1.000 15.72022  ? 38  CYS A C    1 
ATOM   574  O O    . CYS A 1 38  ? -13.31894 36.34936 0.99541   1.000 16.09647  ? 38  CYS A O    1 
ATOM   575  C CB   . CYS A 1 38  ? -15.29861 37.76613 3.35827   1.000 18.08973  ? 38  CYS A CB   1 
ATOM   576  S SG   . CYS A 1 38  ? -15.96818 38.48917 1.80325   1.000 21.15920  ? 38  CYS A SG   1 
ATOM   577  H H    . CYS A 1 38  ? -12.61874 38.19067 2.19953   1.000 17.46322  ? 38  CYS A H    1 
ATOM   578  H HA   . CYS A 1 38  ? -13.76051 36.57870 3.97397   1.000 22.15526  ? 38  CYS A HA   1 
ATOM   579  H HB2  . CYS A 1 38  ? -15.93349 37.10608 3.67789   1.000 21.70768  ? 38  CYS A HB2  1 
ATOM   580  H HB3  . CYS A 1 38  ? -15.21012 38.48240 4.00637   1.000 21.70768  ? 38  CYS A HB3  1 
ATOM   581  H HG   . CYS A 1 38  ? -16.10983 37.61384 0.99471   1.000 25.39104  ? 38  CYS A HG   1 
ATOM   582  N N    . PRO A 1 39  ? -14.58871 34.96498 2.17252   1.000 14.56631  ? 39  PRO A N    1 
ATOM   583  C CA   . PRO A 1 39  ? -14.66389 33.99905 1.06451   1.000 16.99012  ? 39  PRO A CA   1 
ATOM   584  C C    . PRO A 1 39  ? -15.37437 34.58975 -0.14639  1.000 18.52639  ? 39  PRO A C    1 
ATOM   585  O O    . PRO A 1 39  ? -16.40527 35.22668 -0.02823  1.000 16.97627  ? 39  PRO A O    1 
ATOM   586  C CB   . PRO A 1 39  ? -15.46992 32.83982 1.65021   1.000 19.54497  ? 39  PRO A CB   1 
ATOM   587  C CG   . PRO A 1 39  ? -15.23010 32.94398 3.15536   1.000 15.29519  ? 39  PRO A CG   1 
ATOM   588  C CD   . PRO A 1 39  ? -15.21403 34.44692 3.40797   1.000 16.33180  ? 39  PRO A CD   1 
ATOM   589  H HA   . PRO A 1 39  ? -13.77384 33.70154 0.81917   1.000 20.38815  ? 39  PRO A HA   1 
ATOM   590  H HB2  . PRO A 1 39  ? -16.41026 32.94558 1.43694   1.000 23.45397  ? 39  PRO A HB2  1 
ATOM   591  H HB3  . PRO A 1 39  ? -15.14337 31.99591 1.30080   1.000 23.45397  ? 39  PRO A HB3  1 
ATOM   592  H HG2  . PRO A 1 39  ? -15.94985 32.51255 3.64190   1.000 18.35423  ? 39  PRO A HG2  1 
ATOM   593  H HG3  . PRO A 1 39  ? -14.38097 32.53808 3.39016   1.000 18.35423  ? 39  PRO A HG3  1 
ATOM   594  H HD2  . PRO A 1 39  ? -16.11388 34.79272 3.51555   1.000 19.59816  ? 39  PRO A HD2  1 
ATOM   595  H HD3  . PRO A 1 39  ? -14.67961 34.66441 4.18771   1.000 19.59816  ? 39  PRO A HD3  1 
ATOM   596  N N    . ARG A 1 40  ? -14.80685 34.34681 -1.31581  1.000 16.53293  ? 40  ARG A N    1 
ATOM   597  C CA   . ARG A 1 40  ? -15.40642 34.94475 -2.53098  1.000 16.55602  ? 40  ARG A CA   1 
ATOM   598  C C    . ARG A 1 40  ? -16.76953 34.37372 -2.84284  1.000 19.01247  ? 40  ARG A C    1 
ATOM   599  O O    . ARG A 1 40  ? -17.54966 35.04542 -3.55027  1.000 21.87413  ? 40  ARG A O    1 
ATOM   600  C CB   . ARG A 1 40  ? -14.46268 34.81106 -3.71888  1.000 14.71467  ? 40  ARG A CB   1 
ATOM   601  C CG   . ARG A 1 40  ? -14.23792 33.40863 -4.21641  1.000 15.80573  ? 40  ARG A CG   1 
ATOM   602  C CD   . ARG A 1 40  ? -13.40993 33.37748 -5.47342  1.000 13.35265  ? 40  ARG A CD   1 
ATOM   603  N NE   . ARG A 1 40  ? -13.16484 32.01967 -5.89353  1.000 14.92417  ? 40  ARG A NE   1 
ATOM   604  C CZ   . ARG A 1 40  ? -12.53493 31.70655 -7.01228  1.000 18.51245  ? 40  ARG A CZ   1 
ATOM   605  N NH1  . ARG A 1 40  ? -12.04386 32.64336 -7.80315  1.000 20.32772  ? 40  ARG A NH1  1 
ATOM   606  N NH2  . ARG A 1 40  ? -12.41104 30.42939 -7.35702  1.000 18.74680  ? 40  ARG A NH2  1 
ATOM   607  H H    . ARG A 1 40  ? -14.10668 33.86383 -1.44265  1.000 19.83951  ? 40  ARG A H    1 
ATOM   608  H HA   . ARG A 1 40  ? -15.52662 35.89568 -2.38201  1.000 19.86722  ? 40  ARG A HA   1 
ATOM   609  H HB2  . ARG A 1 40  ? -14.82764 35.32372 -4.45705  1.000 17.65760  ? 40  ARG A HB2  1 
ATOM   610  H HB3  . ARG A 1 40  ? -13.59793 35.16801 -3.46258  1.000 17.65760  ? 40  ARG A HB3  1 
ATOM   611  H HG2  . ARG A 1 40  ? -13.77165 32.89959 -3.53496  1.000 18.96688  ? 40  ARG A HG2  1 
ATOM   612  H HG3  . ARG A 1 40  ? -15.09513 32.99760 -4.40916  1.000 18.96688  ? 40  ARG A HG3  1 
ATOM   613  H HD2  . ARG A 1 40  ? -13.88270 33.83881 -6.18374  1.000 16.02318  ? 40  ARG A HD2  1 
ATOM   614  H HD3  . ARG A 1 40  ? -12.55619 33.80767 -5.30920  1.000 16.02318  ? 40  ARG A HD3  1 
ATOM   615  H HE   . ARG A 1 40  ? -13.44309 31.38058 -5.38980  1.000 17.90900  ? 40  ARG A HE   1 
ATOM   616  H HH11 . ARG A 1 40  ? -12.13157 33.47273 -7.59327  1.000 24.39326  ? 40  ARG A HH11 1 
ATOM   617  H HH12 . ARG A 1 40  ? -11.63637 32.42401 -8.52803  1.000 24.39326  ? 40  ARG A HH12 1 
ATOM   618  H HH21 . ARG A 1 40  ? -12.73944 29.81431 -6.85360  1.000 22.49616  ? 40  ARG A HH21 1 
ATOM   619  H HH22 . ARG A 1 40  ? -12.00244 30.21780 -8.08357  1.000 22.49616  ? 40  ARG A HH22 1 
ATOM   620  N N    . HIS A 1 41  ? -17.12538 33.18316 -2.32079  1.000 17.05340  ? 41  HIS A N    1 
ATOM   621  C CA   . HIS A 1 41  ? -18.43604 32.62504 -2.66226  1.000 20.88970  ? 41  HIS A CA   1 
ATOM   622  C C    . HIS A 1 41  ? -19.58388 33.42008 -2.07325  1.000 19.95406  ? 41  HIS A C    1 
ATOM   623  O O    . HIS A 1 41  ? -20.73851 33.10376 -2.40400  1.000 22.96484  ? 41  HIS A O    1 
ATOM   624  C CB   . HIS A 1 41  ? -18.58122 31.13649 -2.33265  1.000 19.08223  ? 41  HIS A CB   1 
ATOM   625  C CG   . HIS A 1 41  ? -18.64095 30.82024 -0.86848  1.000 21.65505  ? 41  HIS A CG   1 
ATOM   626  N ND1  . HIS A 1 41  ? -17.59103 30.27320 -0.17594  1.000 21.42921  ? 41  HIS A ND1  1 
ATOM   627  C CD2  . HIS A 1 41  ? -19.67849 30.86793 -0.00693  1.000 22.34060  ? 41  HIS A CD2  1 
ATOM   628  C CE1  . HIS A 1 41  ? -17.96611 30.05031 1.09509   1.000 16.89756  ? 41  HIS A CE1  1 
ATOM   629  N NE2  . HIS A 1 41  ? -19.23776 30.38908 1.20611   1.000 23.79206  ? 41  HIS A NE2  1 
ATOM   630  H H    . HIS A 1 41  ? -16.64343 32.70634 -1.79167  1.000 20.46408  ? 41  HIS A H    1 
ATOM   631  H HA   . HIS A 1 41  ? -18.50095 32.65900 -3.62949  1.000 25.06763  ? 41  HIS A HA   1 
ATOM   632  H HB2  . HIS A 1 41  ? -19.40135 30.81052 -2.73518  1.000 22.89867  ? 41  HIS A HB2  1 
ATOM   633  H HB3  . HIS A 1 41  ? -17.81935 30.66348 -2.70241  1.000 22.89867  ? 41  HIS A HB3  1 
ATOM   634  H HD2  . HIS A 1 41  ? -20.53699 31.17001 -0.19830  1.000 26.80872  ? 41  HIS A HD2  1 
ATOM   635  H HE1  . HIS A 1 41  ? -17.42647 29.71697 1.77521   1.000 20.27708  ? 41  HIS A HE1  1 
ATOM   636  H HE2  . HIS A 1 41  ? -19.71293 30.32154 1.91973   1.000 28.55047  ? 41  HIS A HE2  1 
ATOM   637  N N    . VAL A 1 42  ? -19.31324 34.45544 -1.28534  1.000 19.82466  ? 42  VAL A N    1 
ATOM   638  C CA   . VAL A 1 42  ? -20.36432 35.34165 -0.79576  1.000 22.31901  ? 42  VAL A CA   1 
ATOM   639  C C    . VAL A 1 42  ? -21.13074 35.96693 -1.95622  1.000 23.33893  ? 42  VAL A C    1 
ATOM   640  O O    . VAL A 1 42  ? -22.29894 36.33557 -1.79513  1.000 24.71198  ? 42  VAL A O    1 
ATOM   641  C CB   . VAL A 1 42  ? -19.79191 36.42173 0.11052   1.000 21.33336  ? 42  VAL A CB   1 
ATOM   642  C CG1  . VAL A 1 42  ? -19.01116 37.43555 -0.67902  1.000 19.95587  ? 42  VAL A CG1  1 
ATOM   643  C CG2  . VAL A 1 42  ? -20.90822 37.11339 0.89339   1.000 26.82706  ? 42  VAL A CG2  1 
ATOM   644  H H    . VAL A 1 42  ? -18.52441 34.66881 -1.01735  1.000 23.78960  ? 42  VAL A H    1 
ATOM   645  H HA   . VAL A 1 42  ? -20.97942 34.81310 -0.26361  1.000 26.78281  ? 42  VAL A HA   1 
ATOM   646  H HB   . VAL A 1 42  ? -19.18661 35.99874 0.73948   1.000 25.60003  ? 42  VAL A HB   1 
ATOM   647  H HG11 . VAL A 1 42  ? -18.43311 37.92847 -0.07587  1.000 23.94704  ? 42  VAL A HG11 1 
ATOM   648  H HG12 . VAL A 1 42  ? -18.47786 36.97439 -1.34522  1.000 23.94704  ? 42  VAL A HG12 1 
ATOM   649  H HG13 . VAL A 1 42  ? -19.63057 38.04259 -1.11345  1.000 23.94704  ? 42  VAL A HG13 1 
ATOM   650  H HG21 . VAL A 1 42  ? -20.51235 37.71757 1.54081   1.000 32.19247  ? 42  VAL A HG21 1 
ATOM   651  H HG22 . VAL A 1 42  ? -21.46630 37.61054 0.27509   1.000 32.19247  ? 42  VAL A HG22 1 
ATOM   652  H HG23 . VAL A 1 42  ? -21.43776 36.44067 1.34938   1.000 32.19247  ? 42  VAL A HG23 1 
ATOM   653  N N    . ILE A 1 43  ? -20.50883 36.05935 -3.12971  1.000 24.43371  ? 43  ILE A N    1 
ATOM   654  C CA   . ILE A 1 43  ? -21.18139 36.70600 -4.28450  1.000 22.59173  ? 43  ILE A CA   1 
ATOM   655  C C    . ILE A 1 43  ? -22.04198 35.75888 -5.08238  1.000 34.99257  ? 43  ILE A C    1 
ATOM   656  O O    . ILE A 1 43  ? -22.70784 36.19468 -6.03331  1.000 35.73290  ? 43  ILE A O    1 
ATOM   657  C CB   . ILE A 1 43  ? -20.19916 37.44021 -5.21865  1.000 20.12740  ? 43  ILE A CB   1 
ATOM   658  C CG1  . ILE A 1 43  ? -19.31417 36.43341 -5.96690  1.000 21.65857  ? 43  ILE A CG1  1 
ATOM   659  C CG2  . ILE A 1 43  ? -19.41355 38.50549 -4.47825  1.000 23.90261  ? 43  ILE A CG2  1 
ATOM   660  C CD1  . ILE A 1 43  ? -18.32734 37.07866 -6.91822  1.000 22.41287  ? 43  ILE A CD1  1 
ATOM   661  H H    . ILE A 1 43  ? -19.71655 35.76625 -3.29087  1.000 29.32045  ? 43  ILE A H    1 
ATOM   662  H HA   . ILE A 1 43  ? -21.76466 37.38023 -3.90225  1.000 27.11007  ? 43  ILE A HA   1 
ATOM   663  H HB   . ILE A 1 43  ? -20.71004 37.91573 -5.89228  1.000 24.15288  ? 43  ILE A HB   1 
ATOM   664  H HG12 . ILE A 1 43  ? -18.80777 35.92039 -5.31785  1.000 25.99029  ? 43  ILE A HG12 1 
ATOM   665  H HG13 . ILE A 1 43  ? -19.88293 35.84313 -6.48553  1.000 25.99029  ? 43  ILE A HG13 1 
ATOM   666  H HG21 . ILE A 1 43  ? -18.98049 39.08489 -5.12451  1.000 28.68313  ? 43  ILE A HG21 1 
ATOM   667  H HG22 . ILE A 1 43  ? -20.02278 39.02151 -3.92738  1.000 28.68313  ? 43  ILE A HG22 1 
ATOM   668  H HG23 . ILE A 1 43  ? -18.74663 38.07551 -3.92036  1.000 28.68313  ? 43  ILE A HG23 1 
ATOM   669  H HD11 . ILE A 1 43  ? -17.82955 36.38347 -7.37628  1.000 26.89545  ? 43  ILE A HD11 1 
ATOM   670  H HD12 . ILE A 1 43  ? -18.81469 37.61569 -7.56242  1.000 26.89545  ? 43  ILE A HD12 1 
ATOM   671  H HD13 . ILE A 1 43  ? -17.72068 37.64031 -6.41088  1.000 26.89545  ? 43  ILE A HD13 1 
ATOM   672  N N    . CYS A 1 44  ? -22.04529 34.48282 -4.75598  1.000 26.78902  ? 44  CYS A N    1 
ATOM   673  C CA   . CYS A 1 44  ? -22.78836 33.50005 -5.52310  1.000 26.92848  ? 44  CYS A CA   1 
ATOM   674  C C    . CYS A 1 44  ? -24.23992 33.40564 -5.06443  1.000 44.07116  ? 44  CYS A C    1 
ATOM   675  O O    . CYS A 1 44  ? -24.58252 33.73496 -3.92422  1.000 43.68435  ? 44  CYS A O    1 
ATOM   676  C CB   . CYS A 1 44  ? -22.14341 32.12079 -5.39685  1.000 35.61862  ? 44  CYS A CB   1 
ATOM   677  S SG   . CYS A 1 44  ? -20.49477 32.03564 -6.09382  1.000 51.58439  ? 44  CYS A SG   1 
ATOM   678  H H    . CYS A 1 44  ? -21.61952 34.15387 -4.08508  1.000 32.14682  ? 44  CYS A H    1 
ATOM   679  H HA   . CYS A 1 44  ? -22.78279 33.77512 -6.45326  1.000 32.31418  ? 44  CYS A HA   1 
ATOM   680  H HB2  . CYS A 1 44  ? -22.08101 31.88974 -4.45684  1.000 42.74235  ? 44  CYS A HB2  1 
ATOM   681  H HB3  . CYS A 1 44  ? -22.69639 31.47340 -5.86161  1.000 42.74235  ? 44  CYS A HB3  1 
ATOM   682  H HG   . CYS A 1 44  ? -20.12419 30.89436 -6.08224  1.000 61.90126  ? 44  CYS A HG   1 
ATOM   683  N N    . THR A 1 45  ? -25.09272 32.96464 -5.99018  1.000 57.06542  ? 45  THR A N    1 
ATOM   684  C CA   . THR A 1 45  ? -26.45451 32.55103 -5.69901  1.000 58.78780  ? 45  THR A CA   1 
ATOM   685  C C    . THR A 1 45  ? -26.51607 31.02739 -5.74532  1.000 65.23694  ? 45  THR A C    1 
ATOM   686  O O    . THR A 1 45  ? -25.54645 30.35258 -6.10757  1.000 66.05878  ? 45  THR A O    1 
ATOM   687  C CB   . THR A 1 45  ? -27.42284 33.13630 -6.72699  1.000 54.95690  ? 45  THR A CB   1 
ATOM   688  O OG1  . THR A 1 45  ? -27.23463 32.46741 -7.97884  1.000 51.75860  ? 45  THR A OG1  1 
ATOM   689  C CG2  . THR A 1 45  ? -27.18431 34.63570 -6.91044  1.000 45.75480  ? 45  THR A CG2  1 
ATOM   690  H H    . THR A 1 45  ? -24.89290 32.89543 -6.82377  1.000 68.47851  ? 45  THR A H    1 
ATOM   691  H HA   . THR A 1 45  ? -26.70600 32.87210 -4.81892  1.000 70.54536  ? 45  THR A HA   1 
ATOM   692  H HB   . THR A 1 45  ? -28.33533 33.01515 -6.42107  1.000 65.94828  ? 45  THR A HB   1 
ATOM   693  H HG1  . THR A 1 45  ? -27.95345 32.46359 -8.41345  1.000 62.11032  ? 45  THR A HG1  1 
ATOM   694  H HG21 . THR A 1 45  ? -26.51425 34.78360 -7.59605  1.000 54.90576  ? 45  THR A HG21 1 
ATOM   695  H HG22 . THR A 1 45  ? -28.00850 35.07267 -7.17630  1.000 54.90576  ? 45  THR A HG22 1 
ATOM   696  H HG23 . THR A 1 45  ? -26.87494 35.02667 -6.07838  1.000 54.90576  ? 45  THR A HG23 1 
ATOM   697  N N    . SER A 1 46  ? -27.68320 30.47880 -5.39869  1.000 67.36188  ? 46  SER A N    1 
ATOM   698  C CA   . SER A 1 46  ? -27.86258 29.02775 -5.44180  1.000 76.12193  ? 46  SER A CA   1 
ATOM   699  C C    . SER A 1 46  ? -27.51254 28.46559 -6.81892  1.000 76.57125  ? 46  SER A C    1 
ATOM   700  O O    . SER A 1 46  ? -26.79093 27.46711 -6.93276  1.000 75.22487  ? 46  SER A O    1 
ATOM   701  C CB   . SER A 1 46  ? -29.30280 28.67192 -5.06200  1.000 73.56767  ? 46  SER A CB   1 
ATOM   702  H H    . SER A 1 46  ? -28.37561 30.91789 -5.13912  1.000 80.83425  ? 46  SER A H    1 
ATOM   703  H HA   . SER A 1 46  ? -27.26787 28.61903 -4.79360  1.000 91.34632  ? 46  SER A HA   1 
ATOM   704  N N    . GLU A 1 47  ? -28.01128 29.10350 -7.88169  1.000 72.71858  ? 47  GLU A N    1 
ATOM   705  C CA   . GLU A 1 47  ? -27.74942 28.60749 -9.22960  1.000 71.44205  ? 47  GLU A CA   1 
ATOM   706  C C    . GLU A 1 47  ? -26.27053 28.72125 -9.59142  1.000 79.14362  ? 47  GLU A C    1 
ATOM   707  O O    . GLU A 1 47  ? -25.69586 27.79595 -10.17959 1.000 80.75645  ? 47  GLU A O    1 
ATOM   708  C CB   . GLU A 1 47  ? -28.60590 29.37478 -10.23511 1.000 63.42198  ? 47  GLU A CB   1 
ATOM   709  H H    . GLU A 1 47  ? -28.49576 29.81325 -7.84818  1.000 87.26230  ? 47  GLU A H    1 
ATOM   710  H HA   . GLU A 1 47  ? -27.99296 27.66945 -9.27056  1.000 85.73046  ? 47  GLU A HA   1 
ATOM   711  N N    . ASP A 1 48  ? -25.63746 29.84696 -9.24909  1.000 78.83408  ? 48  ASP A N    1 
ATOM   712  C CA   . ASP A 1 48  ? -24.23459 30.04530 -9.59984  1.000 81.14767  ? 48  ASP A CA   1 
ATOM   713  C C    . ASP A 1 48  ? -23.35031 28.95808 -9.00454  1.000 76.30134  ? 48  ASP A C    1 
ATOM   714  O O    . ASP A 1 48  ? -22.44028 28.45473 -9.67290  1.000 63.22988  ? 48  ASP A O    1 
ATOM   715  C CB   . ASP A 1 48  ? -23.75984 31.41292 -9.09842  1.000 68.08840  ? 48  ASP A CB   1 
ATOM   716  C CG   . ASP A 1 48  ? -24.39251 32.57005 -9.85575  1.000 74.03670  ? 48  ASP A CG   1 
ATOM   717  O OD1  . ASP A 1 48  ? -24.49655 32.48671 -11.10105 1.000 74.62379  ? 48  ASP A OD1  1 
ATOM   718  O OD2  . ASP A 1 48  ? -24.78031 33.56522 -9.19940  1.000 56.33113  ? 48  ASP A OD2  1 
ATOM   719  H H    . ASP A 1 48  ? -25.99424 30.50102 -8.81953  1.000 94.60089  ? 48  ASP A H    1 
ATOM   720  H HA   . ASP A 1 48  ? -24.15622 30.01507 -10.56620 1.000 97.37720  ? 48  ASP A HA   1 
ATOM   721  H HB2  . ASP A 1 48  ? -23.99342 31.50444 -8.16142  1.000 81.70609  ? 48  ASP A HB2  1 
ATOM   722  H HB3  . ASP A 1 48  ? -22.79793 31.47314 -9.20796  1.000 81.70609  ? 48  ASP A HB3  1 
ATOM   723  N N    . MET A 1 49  ? -23.61170 28.57369 -7.75017  1.000 84.52780  ? 49  MET A N    1 
ATOM   724  C CA   . MET A 1 49  ? -22.67833 27.77007 -6.95942  1.000 72.28266  ? 49  MET A CA   1 
ATOM   725  C C    . MET A 1 49  ? -22.46440 26.36880 -7.51852  1.000 76.20123  ? 49  MET A C    1 
ATOM   726  O O    . MET A 1 49  ? -21.75029 25.57671 -6.88481  1.000 70.63420  ? 49  MET A O    1 
ATOM   727  C CB   . MET A 1 49  ? -23.15914 27.69345 -5.51179  1.000 65.07261  ? 49  MET A CB   1 
ATOM   728  H H    . MET A 1 49  ? -24.33539 28.76962 -7.32888  1.000 101.43336 ? 49  MET A H    1 
ATOM   729  H HA   . MET A 1 49  ? -21.81853 28.21913 -6.95814  1.000 86.73920  ? 49  MET A HA   1 
ATOM   730  N N    . LEU A 1 50  ? -23.04173 26.03706 -8.66743  1.000 78.10679  ? 50  LEU A N    1 
ATOM   731  C CA   . LEU A 1 50  ? -22.72302 24.78344 -9.33519  1.000 75.74586  ? 50  LEU A CA   1 
ATOM   732  C C    . LEU A 1 50  ? -21.34700 24.88772 -9.98124  1.000 69.36183  ? 50  LEU A C    1 
ATOM   733  O O    . LEU A 1 50  ? -20.39611 24.23218 -9.53836  1.000 63.00018  ? 50  LEU A O    1 
ATOM   734  C CB   . LEU A 1 50  ? -23.78412 24.44211 -10.37998 1.000 75.12954  ? 50  LEU A CB   1 
ATOM   735  H H    . LEU A 1 50  ? -23.62085 26.52097 -9.07980  1.000 93.72815  ? 50  LEU A H    1 
ATOM   736  H HA   . LEU A 1 50  ? -22.71257 24.06033 -8.68874  1.000 90.89503  ? 50  LEU A HA   1 
ATOM   737  N N    . ASN A 1 51  ? -21.23230 25.70973 -11.02673 1.000 72.13903  ? 51  ASN A N    1 
ATOM   738  C CA   . ASN A 1 51  ? -19.96103 25.95082 -11.71506 1.000 64.04679  ? 51  ASN A CA   1 
ATOM   739  C C    . ASN A 1 51  ? -19.82459 27.44595 -11.98355 1.000 53.54495  ? 51  ASN A C    1 
ATOM   740  O O    . ASN A 1 51  ? -20.03477 27.91592 -13.10484 1.000 62.53194  ? 51  ASN A O    1 
ATOM   741  C CB   . ASN A 1 51  ? -19.88088 25.14990 -13.01558 1.000 62.11014  ? 51  ASN A CB   1 
ATOM   742  H H    . ASN A 1 51  ? -21.89086 26.14875 -11.36311 1.000 86.56684  ? 51  ASN A H    1 
ATOM   743  H HA   . ASN A 1 51  ? -19.22945 25.67636 -11.14028 1.000 76.85615  ? 51  ASN A HA   1 
ATOM   744  N N    . PRO A 1 52  ? -19.46073 28.22594 -10.97291 1.000 51.54522  ? 52  PRO A N    1 
ATOM   745  C CA   . PRO A 1 52  ? -19.45926 29.68183 -11.13655 1.000 46.92545  ? 52  PRO A CA   1 
ATOM   746  C C    . PRO A 1 52  ? -18.19810 30.19431 -11.80288 1.000 44.38813  ? 52  PRO A C    1 
ATOM   747  O O    . PRO A 1 52  ? -17.09915 29.67514 -11.60754 1.000 39.39889  ? 52  PRO A O    1 
ATOM   748  C CB   . PRO A 1 52  ? -19.55698 30.19706 -9.69256  1.000 45.80959  ? 52  PRO A CB   1 
ATOM   749  C CG   . PRO A 1 52  ? -19.07722 29.05486 -8.81377  1.000 56.11933  ? 52  PRO A CG   1 
ATOM   750  C CD   . PRO A 1 52  ? -18.94901 27.81412 -9.65572  1.000 51.60412  ? 52  PRO A CD   1 
ATOM   751  H HA   . PRO A 1 52  ? -20.23268 29.96534 -11.64875 1.000 56.31053  ? 52  PRO A HA   1 
ATOM   752  H HB2  . PRO A 1 52  ? -18.98982 30.97650 -9.58433  1.000 54.97151  ? 52  PRO A HB2  1 
ATOM   753  H HB3  . PRO A 1 52  ? -20.47731 30.42552 -9.48839  1.000 54.97151  ? 52  PRO A HB3  1 
ATOM   754  H HG2  . PRO A 1 52  ? -18.21584 29.28977 -8.43465  1.000 67.34320  ? 52  PRO A HG2  1 
ATOM   755  H HG3  . PRO A 1 52  ? -19.72337 28.91025 -8.10492  1.000 67.34320  ? 52  PRO A HG3  1 
ATOM   756  H HD2  . PRO A 1 52  ? -18.02153 27.53731 -9.71943  1.000 61.92494  ? 52  PRO A HD2  1 
ATOM   757  H HD3  . PRO A 1 52  ? -19.48571 27.09405 -9.28919  1.000 61.92494  ? 52  PRO A HD3  1 
ATOM   758  N N    . ASN A 1 53  ? -18.36784 31.25149 -12.60929 1.000 33.48451  ? 53  ASN A N    1 
ATOM   759  C CA   . ASN A 1 53  ? -17.23991 32.01203 -13.11661 1.000 27.78723  ? 53  ASN A CA   1 
ATOM   760  C C    . ASN A 1 53  ? -17.12750 33.25124 -12.23345 1.000 39.37566  ? 53  ASN A C    1 
ATOM   761  O O    . ASN A 1 53  ? -17.87240 34.22185 -12.40904 1.000 24.98990  ? 53  ASN A O    1 
ATOM   762  C CB   . ASN A 1 53  ? -17.40212 32.40420 -14.57580 1.000 41.25509  ? 53  ASN A CB   1 
ATOM   763  C CG   . ASN A 1 53  ? -16.13644 32.99048 -15.13688 1.000 46.24039  ? 53  ASN A CG   1 
ATOM   764  O OD1  . ASN A 1 53  ? -15.80538 34.14398 -14.87544 1.000 35.58785  ? 53  ASN A OD1  1 
ATOM   765  N ND2  . ASN A 1 53  ? -15.37869 32.17876 -15.87247 1.000 62.03695  ? 53  ASN A ND2  1 
ATOM   766  H H    . ASN A 1 53  ? -19.13388 31.54092 -12.87197 1.000 40.18141  ? 53  ASN A H    1 
ATOM   767  H HA   . ASN A 1 53  ? -16.43987 31.46701 -13.05517 1.000 33.34468  ? 53  ASN A HA   1 
ATOM   768  H HB2  . ASN A 1 53  ? -17.62987 31.61747 -15.09550 1.000 49.50611  ? 53  ASN A HB2  1 
ATOM   769  H HB3  . ASN A 1 53  ? -18.10544 33.06775 -14.65286 1.000 49.50611  ? 53  ASN A HB3  1 
ATOM   770  H HD21 . ASN A 1 53  ? -15.62317 31.36495 -16.00491 1.000 74.44434  ? 53  ASN A HD21 1 
ATOM   771  H HD22 . ASN A 1 53  ? -14.64496 32.46848 -16.21497 1.000 74.44434  ? 53  ASN A HD22 1 
ATOM   772  N N    . TYR A 1 54  ? -16.19077 33.22291 -11.27175 1.000 27.71628  ? 54  TYR A N    1 
ATOM   773  C CA   . TYR A 1 54  ? -16.17635 34.27269 -10.29134 1.000 23.57509  ? 54  TYR A CA   1 
ATOM   774  C C    . TYR A 1 54  ? -15.78135 35.60956 -10.88944 1.000 22.91913  ? 54  TYR A C    1 
ATOM   775  O O    . TYR A 1 54  ? -16.19755 36.65286 -10.38705 1.000 23.70438  ? 54  TYR A O    1 
ATOM   776  C CB   . TYR A 1 54  ? -15.21486 33.89074 -9.14516  1.000 20.56021  ? 54  TYR A CB   1 
ATOM   777  C CG   . TYR A 1 54  ? -15.81442 32.89730 -8.21902  1.000 18.43674  ? 54  TYR A CG   1 
ATOM   778  C CD1  . TYR A 1 54  ? -16.68107 33.29438 -7.21287  1.000 22.08228  ? 54  TYR A CD1  1 
ATOM   779  C CD2  . TYR A 1 54  ? -15.48792 31.54134 -8.29564  1.000 21.03985  ? 54  TYR A CD2  1 
ATOM   780  C CE1  . TYR A 1 54  ? -17.21481 32.40104 -6.33345  1.000 22.26250  ? 54  TYR A CE1  1 
ATOM   781  C CE2  . TYR A 1 54  ? -16.03724 30.63386 -7.40479  1.000 19.87851  ? 54  TYR A CE2  1 
ATOM   782  C CZ   . TYR A 1 54  ? -16.90140 31.05783 -6.43837  1.000 20.58718  ? 54  TYR A CZ   1 
ATOM   783  O OH   . TYR A 1 54  ? -17.45339 30.19510 -5.54606  1.000 25.48854  ? 54  TYR A OH   1 
ATOM   784  H H    . TYR A 1 54  ? -15.58218 32.62184 -11.18266 1.000 33.25954  ? 54  TYR A H    1 
ATOM   785  H HA   . TYR A 1 54  ? -17.06940 34.37267 -9.92615  1.000 28.29011  ? 54  TYR A HA   1 
ATOM   786  H HB2  . TYR A 1 54  ? -14.40825 33.50546 -9.52177  1.000 24.67225  ? 54  TYR A HB2  1 
ATOM   787  H HB3  . TYR A 1 54  ? -14.99578 34.68637 -8.63538  1.000 24.67225  ? 54  TYR A HB3  1 
ATOM   788  H HD1  . TYR A 1 54  ? -16.90405 34.19398 -7.13604  1.000 26.49874  ? 54  TYR A HD1  1 
ATOM   789  H HD2  . TYR A 1 54  ? -14.89700 31.24542 -8.94998  1.000 25.24782  ? 54  TYR A HD2  1 
ATOM   790  H HE1  . TYR A 1 54  ? -17.78925 32.69402 -5.66332  1.000 26.71500  ? 54  TYR A HE1  1 
ATOM   791  H HE2  . TYR A 1 54  ? -15.81611 29.73260 -7.46582  1.000 23.85421  ? 54  TYR A HE2  1 
ATOM   792  H HH   . TYR A 1 54  ? -17.99035 30.60375 -5.04577  1.000 30.58624  ? 54  TYR A HH   1 
ATOM   793  N N    . GLU A 1 55  ? -14.96412 35.60759 -11.93886 1.000 24.00688  ? 55  GLU A N    1 
ATOM   794  C CA   . GLU A 1 55  ? -14.55494 36.86715 -12.52931 1.000 22.88782  ? 55  GLU A CA   1 
ATOM   795  C C    . GLU A 1 55  ? -15.76845 37.56562 -13.15644 1.000 25.56403  ? 55  GLU A C    1 
ATOM   796  O O    . GLU A 1 55  ? -15.96986 38.76418 -12.94268 1.000 25.43308  ? 55  GLU A O    1 
ATOM   797  C CB   . GLU A 1 55  ? -13.45778 36.61336 -13.56851 1.000 30.03444  ? 55  GLU A CB   1 
ATOM   798  C CG   . GLU A 1 55  ? -12.15998 36.01846 -12.96721 1.000 44.26293  ? 55  GLU A CG   1 
ATOM   799  C CD   . GLU A 1 55  ? -12.30919 34.55838 -12.47911 1.000 76.62901  ? 55  GLU A CD   1 
ATOM   800  O OE1  . GLU A 1 55  ? -13.10341 33.78651 -13.06899 1.000 58.86920  ? 55  GLU A OE1  1 
ATOM   801  O OE2  . GLU A 1 55  ? -11.63516 34.18293 -11.48877 1.000 76.95717  ? 55  GLU A OE2  1 
ATOM   802  H H    . GLU A 1 55  ? -14.64193 34.90527 -12.31641 1.000 28.80825  ? 55  GLU A H    1 
ATOM   803  H HA   . GLU A 1 55  ? -14.18215 37.45302 -11.85205 1.000 27.46539  ? 55  GLU A HA   1 
ATOM   804  H HB2  . GLU A 1 55  ? -13.79254 35.98765 -14.22982 1.000 36.04132  ? 55  GLU A HB2  1 
ATOM   805  H HB3  . GLU A 1 55  ? -13.22944 37.45481 -13.99363 1.000 36.04132  ? 55  GLU A HB3  1 
ATOM   806  H HG2  . GLU A 1 55  ? -11.46648 36.03377 -13.64524 1.000 53.11551  ? 55  GLU A HG2  1 
ATOM   807  H HG3  . GLU A 1 55  ? -11.89255 36.55815 -12.20687 1.000 53.11551  ? 55  GLU A HG3  1 
ATOM   808  N N    . ASP A 1 56  ? -16.59480 36.79921 -13.84720 1.000 27.22167  ? 56  ASP A N    1 
ATOM   809  C CA   . ASP A 1 56  ? -17.85887 37.32540 -14.37735 1.000 33.64984  ? 56  ASP A CA   1 
ATOM   810  C C    . ASP A 1 56  ? -18.77750 37.78819 -13.24838 1.000 35.89287  ? 56  ASP A C    1 
ATOM   811  O O    . ASP A 1 56  ? -19.36831 38.87898 -13.31891 1.000 27.94765  ? 56  ASP A O    1 
ATOM   812  C CB   . ASP A 1 56  ? -18.56815 36.24745 -15.19728 1.000 37.64807  ? 56  ASP A CB   1 
ATOM   813  C CG   . ASP A 1 56  ? -18.06733 36.15895 -16.62224 1.000 47.06408  ? 56  ASP A CG   1 
ATOM   814  O OD1  . ASP A 1 56  ? -17.24159 37.00743 -17.02586 1.000 42.07162  ? 56  ASP A OD1  1 
ATOM   815  O OD2  . ASP A 1 56  ? -18.51153 35.23266 -17.33977 1.000 50.65491  ? 56  ASP A OD2  1 
ATOM   816  H H    . ASP A 1 56  ? -16.45582 35.97000 -14.02801 1.000 32.66600  ? 56  ASP A H    1 
ATOM   817  H HA   . ASP A 1 56  ? -17.65951 38.08131 -14.95159 1.000 40.37981  ? 56  ASP A HA   1 
ATOM   818  H HB2  . ASP A 1 56  ? -18.42355 35.38568 -14.77615 1.000 45.17768  ? 56  ASP A HB2  1 
ATOM   819  H HB3  . ASP A 1 56  ? -19.51685 36.44749 -15.22634 1.000 45.17768  ? 56  ASP A HB3  1 
ATOM   820  N N    . LEU A 1 57  ? -18.92940 36.95749 -12.19804 1.000 25.27092  ? 57  LEU A N    1 
ATOM   821  C CA   . LEU A 1 57  ? -19.83756 37.31340 -11.12832 1.000 24.12468  ? 57  LEU A CA   1 
ATOM   822  C C    . LEU A 1 57  ? -19.41093 38.60719 -10.46412 1.000 22.72855  ? 57  LEU A C    1 
ATOM   823  O O    . LEU A 1 57  ? -20.25246 39.42452 -10.08277 1.000 25.28298  ? 57  LEU A O    1 
ATOM   824  C CB   . LEU A 1 57  ? -19.92800 36.17926 -10.09756 1.000 25.64834  ? 57  LEU A CB   1 
ATOM   825  C CG   . LEU A 1 57  ? -20.56475 34.88546 -10.61510 1.000 33.09502  ? 57  LEU A CG   1 
ATOM   826  C CD1  . LEU A 1 57  ? -20.59872 33.82493 -9.52241  1.000 34.02972  ? 57  LEU A CD1  1 
ATOM   827  C CD2  . LEU A 1 57  ? -21.98285 35.13126 -11.13422 1.000 38.06840  ? 57  LEU A CD2  1 
ATOM   828  H H    . LEU A 1 57  ? -18.52338 36.20619 -12.09663 1.000 30.32510  ? 57  LEU A H    1 
ATOM   829  H HA   . LEU A 1 57  ? -20.72381 37.43948 -11.50190 1.000 28.94962  ? 57  LEU A HA   1 
ATOM   830  H HB2  . LEU A 1 57  ? -19.03050 35.96376 -9.79931  1.000 30.77801  ? 57  LEU A HB2  1 
ATOM   831  H HB3  . LEU A 1 57  ? -20.46147 36.48766 -9.34843  1.000 30.77801  ? 57  LEU A HB3  1 
ATOM   832  H HG   . LEU A 1 57  ? -20.02305 34.56060 -11.35126 1.000 39.71402  ? 57  LEU A HG   1 
ATOM   833  H HD11 . LEU A 1 57  ? -21.03452 33.02995 -9.86735  1.000 40.83566  ? 57  LEU A HD11 1 
ATOM   834  H HD12 . LEU A 1 57  ? -19.68947 33.61515 -9.25755  1.000 40.83566  ? 57  LEU A HD12 1 
ATOM   835  H HD13 . LEU A 1 57  ? -21.09330 34.17000 -8.76267  1.000 40.83566  ? 57  LEU A HD13 1 
ATOM   836  H HD21 . LEU A 1 57  ? -22.53663 34.36574 -10.91465 1.000 45.68208  ? 57  LEU A HD21 1 
ATOM   837  H HD22 . LEU A 1 57  ? -22.33940 35.92908 -10.71320 1.000 45.68208  ? 57  LEU A HD22 1 
ATOM   838  H HD23 . LEU A 1 57  ? -21.95062 35.25116 -12.09624 1.000 45.68208  ? 57  LEU A HD23 1 
ATOM   839  N N    . LEU A 1 58  ? -18.09127 38.82737 -10.32171 1.000 20.19618  ? 58  LEU A N    1 
ATOM   840  C CA   . LEU A 1 58  ? -17.63770 39.97632 -9.58687  1.000 19.96373  ? 58  LEU A CA   1 
ATOM   841  C C    . LEU A 1 58  ? -17.73085 41.25995 -10.39850 1.000 18.67013  ? 58  LEU A C    1 
ATOM   842  O O    . LEU A 1 58  ? -17.97723 42.32343 -9.81830  1.000 20.00791  ? 58  LEU A O    1 
ATOM   843  C CB   . LEU A 1 58  ? -16.19326 39.76714 -9.08824  1.000 25.65064  ? 58  LEU A CB   1 
ATOM   844  C CG   . LEU A 1 58  ? -15.70401 40.86214 -8.14061  1.000 24.22543  ? 58  LEU A CG   1 
ATOM   845  C CD1  . LEU A 1 58  ? -16.55585 40.95957 -6.88092  1.000 23.57537  ? 58  LEU A CD1  1 
ATOM   846  C CD2  . LEU A 1 58  ? -14.24980 40.60722 -7.75284  1.000 27.05082  ? 58  LEU A CD2  1 
ATOM   847  H H    . LEU A 1 58  ? -17.46782 38.32786 -10.64014 1.000 24.23542  ? 58  LEU A H    1 
ATOM   848  H HA   . LEU A 1 58  ? -18.20591 40.07788 -8.80730  1.000 23.95648  ? 58  LEU A HA   1 
ATOM   849  H HB2  . LEU A 1 58  ? -16.14705 38.92209 -8.61427  1.000 30.78077  ? 58  LEU A HB2  1 
ATOM   850  H HB3  . LEU A 1 58  ? -15.59889 39.75060 -9.85463  1.000 30.78077  ? 58  LEU A HB3  1 
ATOM   851  H HG   . LEU A 1 58  ? -15.77609 41.70984 -8.60658  1.000 29.07051  ? 58  LEU A HG   1 
ATOM   852  H HD11 . LEU A 1 58  ? -16.06767 41.45849 -6.20737  1.000 28.29045  ? 58  LEU A HD11 1 
ATOM   853  H HD12 . LEU A 1 58  ? -17.38464 41.41598 -7.09466  1.000 28.29045  ? 58  LEU A HD12 1 
ATOM   854  H HD13 . LEU A 1 58  ? -16.74485 40.06481 -6.55752  1.000 28.29045  ? 58  LEU A HD13 1 
ATOM   855  H HD21 . LEU A 1 58  ? -13.96981 41.28279 -7.11557  1.000 32.46099  ? 58  LEU A HD21 1 
ATOM   856  H HD22 . LEU A 1 58  ? -14.17931 39.72616 -7.35327  1.000 32.46099  ? 58  LEU A HD22 1 
ATOM   857  H HD23 . LEU A 1 58  ? -13.69772 40.65450 -8.54900  1.000 32.46099  ? 58  LEU A HD23 1 
ATOM   858  N N    . ILE A 1 59  ? -17.53016 41.17995 -11.71516 1.000 24.14266  ? 59  ILE A N    1 
ATOM   859  C CA   . ILE A 1 59  ? -17.63622 42.39151 -12.52919 1.000 22.42008  ? 59  ILE A CA   1 
ATOM   860  C C    . ILE A 1 59  ? -19.06335 42.93196 -12.50173 1.000 22.46622  ? 59  ILE A C    1 
ATOM   861  O O    . ILE A 1 59  ? -19.27732 44.13325 -12.69327 1.000 23.21570  ? 59  ILE A O    1 
ATOM   862  C CB   . ILE A 1 59  ? -17.10810 42.14549 -13.97218 1.000 23.74200  ? 59  ILE A CB   1 
ATOM   863  C CG1  . ILE A 1 59  ? -16.96694 43.47949 -14.71141 1.000 29.86017  ? 59  ILE A CG1  1 
ATOM   864  C CG2  . ILE A 1 59  ? -18.03187 41.26151 -14.74990 1.000 28.79039  ? 59  ILE A CG2  1 
ATOM   865  C CD1  . ILE A 1 59  ? -15.84894 44.35659 -14.18716 1.000 39.19699  ? 59  ILE A CD1  1 
ATOM   866  H H    . ILE A 1 59  ? -17.33801 40.46158 -12.14717 1.000 28.97119  ? 59  ILE A H    1 
ATOM   867  H HA   . ILE A 1 59  ? -17.06313 43.07274 -12.14397 1.000 26.90410  ? 59  ILE A HA   1 
ATOM   868  H HB   . ILE A 1 59  ? -16.24533 41.70906 -13.89440 1.000 28.49040  ? 59  ILE A HB   1 
ATOM   869  H HG12 . ILE A 1 59  ? -16.78680 43.29919 -15.64733 1.000 35.83221  ? 59  ILE A HG12 1 
ATOM   870  H HG13 . ILE A 1 59  ? -17.79671 43.97394 -14.62253 1.000 35.83221  ? 59  ILE A HG13 1 
ATOM   871  H HG21 . ILE A 1 59  ? -17.72284 41.21168 -15.66801 1.000 34.54847  ? 59  ILE A HG21 1 
ATOM   872  H HG22 . ILE A 1 59  ? -18.03156 40.37674 -14.35230 1.000 34.54847  ? 59  ILE A HG22 1 
ATOM   873  H HG23 . ILE A 1 59  ? -18.92601 41.63649 -14.72174 1.000 34.54847  ? 59  ILE A HG23 1 
ATOM   874  H HD11 . ILE A 1 59  ? -15.78446 45.15056 -14.74065 1.000 47.03638  ? 59  ILE A HD11 1 
ATOM   875  H HD12 . ILE A 1 59  ? -16.04711 44.60707 -13.27125 1.000 47.03638  ? 59  ILE A HD12 1 
ATOM   876  H HD13 . ILE A 1 59  ? -15.01595 43.86078 -14.22165 1.000 47.03638  ? 59  ILE A HD13 1 
ATOM   877  N N    . ARG A 1 60  ? -20.04296 42.07136 -12.27049 1.000 21.25003  ? 60  ARG A N    1 
ATOM   878  C CA   . ARG A 1 60  ? -21.44418 42.47281 -12.19156 1.000 21.04732  ? 60  ARG A CA   1 
ATOM   879  C C    . ARG A 1 60  ? -21.82734 43.06584 -10.85732 1.000 25.03012  ? 60  ARG A C    1 
ATOM   880  O O    . ARG A 1 60  ? -22.98707 43.46359 -10.70913 1.000 22.89704  ? 60  ARG A O    1 
ATOM   881  C CB   . ARG A 1 60  ? -22.35113 41.30709 -12.52070 1.000 20.13477  ? 60  ARG A CB   1 
ATOM   882  C CG   . ARG A 1 60  ? -22.11235 40.79583 -13.92068 1.000 18.77871  ? 60  ARG A CG   1 
ATOM   883  C CD   . ARG A 1 60  ? -22.77821 39.48856 -14.21267 1.000 23.79674  ? 60  ARG A CD   1 
ATOM   884  N NE   . ARG A 1 60  ? -22.29611 38.95605 -15.47912 1.000 24.15062  ? 60  ARG A NE   1 
ATOM   885  C CZ   . ARG A 1 60  ? -22.28825 37.67190 -15.80747 1.000 32.62648  ? 60  ARG A CZ   1 
ATOM   886  N NH1  . ARG A 1 60  ? -22.78725 36.75462 -14.99756 1.000 33.52930  ? 60  ARG A NH1  1 
ATOM   887  N NH2  . ARG A 1 60  ? -21.76192 37.30392 -16.97248 1.000 35.18625  ? 60  ARG A NH2  1 
ATOM   888  H H    . ARG A 1 60  ? -19.92216 41.22809 -12.15255 1.000 25.50004  ? 60  ARG A H    1 
ATOM   889  H HA   . ARG A 1 60  ? -21.59585 43.15623 -12.86300 1.000 25.25678  ? 60  ARG A HA   1 
ATOM   890  H HB2  . ARG A 1 60  ? -22.18073 40.58310 -11.89803 1.000 24.16172  ? 60  ARG A HB2  1 
ATOM   891  H HB3  . ARG A 1 60  ? -23.27591 41.59193 -12.45325 1.000 24.16172  ? 60  ARG A HB3  1 
ATOM   892  H HG2  . ARG A 1 60  ? -22.45351 41.44752 -14.55298 1.000 22.53446  ? 60  ARG A HG2  1 
ATOM   893  H HG3  . ARG A 1 60  ? -21.15858 40.67565 -14.05023 1.000 22.53446  ? 60  ARG A HG3  1 
ATOM   894  H HD2  . ARG A 1 60  ? -22.57289 38.85294 -13.50929 1.000 28.55609  ? 60  ARG A HD2  1 
ATOM   895  H HD3  . ARG A 1 60  ? -23.73771 39.61705 -14.27399 1.000 28.55609  ? 60  ARG A HD3  1 
ATOM   896  H HE   . ARG A 1 60  ? -21.99392 39.51647 -16.05723 1.000 28.98074  ? 60  ARG A HE   1 
ATOM   897  H HH11 . ARG A 1 60  ? -23.12528 36.98654 -14.24155 1.000 40.23515  ? 60  ARG A HH11 1 
ATOM   898  H HH12 . ARG A 1 60  ? -22.77396 35.92576 -15.22649 1.000 40.23515  ? 60  ARG A HH12 1 
ATOM   899  H HH21 . ARG A 1 60  ? -21.43242 37.89631 -17.50173 1.000 42.22350  ? 60  ARG A HH21 1 
ATOM   900  H HH22 . ARG A 1 60  ? -21.75116 36.47365 -17.19638 1.000 42.22350  ? 60  ARG A HH22 1 
ATOM   901  N N    . LYS A 1 61  ? -20.90775 43.10915 -9.88957  1.000 22.85274  ? 61  LYS A N    1 
ATOM   902  C CA   . LYS A 1 61  ? -21.16129 43.65322 -8.57246  1.000 18.71114  ? 61  LYS A CA   1 
ATOM   903  C C    . LYS A 1 61  ? -20.59803 45.06234 -8.45249  1.000 22.68617  ? 61  LYS A C    1 
ATOM   904  O O    . LYS A 1 61  ? -19.68042 45.45421 -9.18336  1.000 25.96792  ? 61  LYS A O    1 
ATOM   905  C CB   . LYS A 1 61  ? -20.50284 42.76404 -7.47635  1.000 20.71693  ? 61  LYS A CB   1 
ATOM   906  C CG   . LYS A 1 61  ? -21.11623 41.37875 -7.41625  1.000 22.10389  ? 61  LYS A CG   1 
ATOM   907  C CD   . LYS A 1 61  ? -22.48890 41.39934 -6.79642  1.000 30.06934  ? 61  LYS A CD   1 
ATOM   908  C CE   . LYS A 1 61  ? -23.04326 40.00283 -6.67541  1.000 34.14557  ? 61  LYS A CE   1 
ATOM   909  N NZ   . LYS A 1 61  ? -24.50589 39.99358 -6.70148  1.000 40.69424  ? 61  LYS A NZ   1 
ATOM   910  H H    . LYS A 1 61  ? -20.10451 42.81694 -9.98446  1.000 27.42329  ? 61  LYS A H    1 
ATOM   911  H HA   . LYS A 1 61  ? -22.12024 43.68270 -8.42951  1.000 22.45336  ? 61  LYS A HA   1 
ATOM   912  H HB2  . LYS A 1 61  ? -19.55737 42.66813 -7.67077  1.000 24.86032  ? 61  LYS A HB2  1 
ATOM   913  H HB3  . LYS A 1 61  ? -20.62249 43.18573 -6.61104  1.000 24.86032  ? 61  LYS A HB3  1 
ATOM   914  H HG2  . LYS A 1 61  ? -21.19492 41.02444 -8.31579  1.000 26.52467  ? 61  LYS A HG2  1 
ATOM   915  H HG3  . LYS A 1 61  ? -20.55019 40.80124 -6.88054  1.000 26.52467  ? 61  LYS A HG3  1 
ATOM   916  H HD2  . LYS A 1 61  ? -22.43784 41.78807 -5.90919  1.000 36.08321  ? 61  LYS A HD2  1 
ATOM   917  H HD3  . LYS A 1 61  ? -23.08788 41.92098 -7.35321  1.000 36.08321  ? 61  LYS A HD3  1 
ATOM   918  H HE2  . LYS A 1 61  ? -22.72302 39.46624 -7.41731  1.000 40.97469  ? 61  LYS A HE2  1 
ATOM   919  H HE3  . LYS A 1 61  ? -22.75215 39.61488 -5.83539  1.000 40.97469  ? 61  LYS A HE3  1 
ATOM   920  H HZ1  . LYS A 1 61  ? -24.80814 39.17344 -6.53378  1.000 48.83308  ? 61  LYS A HZ1  1 
ATOM   921  H HZ2  . LYS A 1 61  ? -24.82486 40.55062 -6.08498  1.000 48.83308  ? 61  LYS A HZ2  1 
ATOM   922  H HZ3  . LYS A 1 61  ? -24.79771 40.25090 -7.50193  1.000 48.83308  ? 61  LYS A HZ3  1 
ATOM   923  N N    . SER A 1 62  ? -21.14994 45.81679 -7.49565  1.000 25.28244  ? 62  SER A N    1 
ATOM   924  C CA   . SER A 1 62  ? -20.68012 47.14012 -7.13481  1.000 28.32498  ? 62  SER A CA   1 
ATOM   925  C C    . SER A 1 62  ? -20.37607 47.17162 -5.62690  1.000 21.16161  ? 62  SER A C    1 
ATOM   926  O O    . SER A 1 62  ? -20.80823 46.28332 -4.88037  1.000 27.23601  ? 62  SER A O    1 
ATOM   927  C CB   . SER A 1 62  ? -21.76243 48.19790 -7.41021  1.000 38.39348  ? 62  SER A CB   1 
ATOM   928  O OG   . SER A 1 62  ? -22.20593 48.13917 -8.75541  1.000 51.78660  ? 62  SER A OG   1 
ATOM   929  H H    . SER A 1 62  ? -21.82568 45.56494 -7.02709  1.000 30.33892  ? 62  SER A H    1 
ATOM   930  H HA   . SER A 1 62  ? -19.88040 47.34751 -7.64307  1.000 33.98998  ? 62  SER A HA   1 
ATOM   931  H HB2  . SER A 1 62  ? -22.51724 48.03560 -6.82299  1.000 46.07218  ? 62  SER A HB2  1 
ATOM   932  H HB3  . SER A 1 62  ? -21.39242 49.07812 -7.23934  1.000 46.07218  ? 62  SER A HB3  1 
ATOM   933  H HG   . SER A 1 62  ? -21.61608 48.45021 -9.26623  1.000 62.14392  ? 62  SER A HG   1 
ATOM   934  N N    . ASN A 1 63  ? -19.63373 48.19557 -5.20172  1.000 23.80465  ? 63  ASN A N    1 
ATOM   935  C CA   . ASN A 1 63  ? -19.34879 48.37239 -3.77787  1.000 23.14647  ? 63  ASN A CA   1 
ATOM   936  C C    . ASN A 1 63  ? -20.61518 48.32284 -2.93735  1.000 25.04312  ? 63  ASN A C    1 
ATOM   937  O O    . ASN A 1 63  ? -20.62882 47.73685 -1.83253  1.000 24.93953  ? 63  ASN A O    1 
ATOM   938  C CB   . ASN A 1 63  ? -18.63614 49.70649 -3.53185  1.000 26.48765  ? 63  ASN A CB   1 
ATOM   939  C CG   . ASN A 1 63  ? -17.20796 49.72603 -4.03654  1.000 32.24738  ? 63  ASN A CG   1 
ATOM   940  O OD1  . ASN A 1 63  ? -16.54874 48.69223 -4.13069  1.000 25.89659  ? 63  ASN A OD1  1 
ATOM   941  N ND2  . ASN A 1 63  ? -16.69854 50.92898 -4.33655  1.000 30.77864  ? 63  ASN A ND2  1 
ATOM   942  H H    . ASN A 1 63  ? -19.28689 48.79542 -5.71111  1.000 28.56558  ? 63  ASN A H    1 
ATOM   943  H HA   . ASN A 1 63  ? -18.76262 47.64944 -3.50464  1.000 27.77576  ? 63  ASN A HA   1 
ATOM   944  H HB2  . ASN A 1 63  ? -19.12251 50.41093 -3.98805  1.000 31.78517  ? 63  ASN A HB2  1 
ATOM   945  H HB3  . ASN A 1 63  ? -18.61691 49.88079 -2.57783  1.000 31.78517  ? 63  ASN A HB3  1 
ATOM   946  H HD21 . ASN A 1 63  ? -15.89172 50.99397 -4.62708  1.000 36.93437  ? 63  ASN A HD21 1 
ATOM   947  H HD22 . ASN A 1 63  ? -17.17852 51.63581 -4.23851  1.000 36.93437  ? 63  ASN A HD22 1 
ATOM   948  N N    . HIS A 1 64  ? -21.71460 48.90680 -3.43283  1.000 27.61065  ? 64  HIS A N    1 
ATOM   949  C CA   . HIS A 1 64  ? -22.92298 49.00067 -2.63307  1.000 27.38455  ? 64  HIS A CA   1 
ATOM   950  C C    . HIS A 1 64  ? -23.64311 47.67655 -2.47875  1.000 28.05452  ? 64  HIS A C    1 
ATOM   951  O O    . HIS A 1 64  ? -24.53258 47.57633 -1.63555  1.000 32.11072  ? 64  HIS A O    1 
ATOM   952  C CB   . HIS A 1 64  ? -23.87872 50.05937 -3.22509  1.000 37.00801  ? 64  HIS A CB   1 
ATOM   953  C CG   . HIS A 1 64  ? -24.58813 49.60941 -4.45731  1.000 38.74115  ? 64  HIS A CG   1 
ATOM   954  N ND1  . HIS A 1 64  ? -24.14414 49.92401 -5.72551  1.000 47.11322  ? 64  HIS A ND1  1 
ATOM   955  C CD2  . HIS A 1 64  ? -25.72058 48.88387 -4.62472  1.000 37.80152  ? 64  HIS A CD2  1 
ATOM   956  C CE1  . HIS A 1 64  ? -24.96344 49.39797 -6.61941  1.000 43.75532  ? 64  HIS A CE1  1 
ATOM   957  N NE2  . HIS A 1 64  ? -25.92764 48.76233 -5.97876  1.000 49.14583  ? 64  HIS A NE2  1 
ATOM   958  H H    . HIS A 1 64  ? -21.77703 49.24907 -4.21931  1.000 33.13278  ? 64  HIS A H    1 
ATOM   959  H HA   . HIS A 1 64  ? -22.67350 49.29719 -1.74383  1.000 32.86146  ? 64  HIS A HA   1 
ATOM   960  H HB2  . HIS A 1 64  ? -24.55048 50.27889 -2.56067  1.000 44.40961  ? 64  HIS A HB2  1 
ATOM   961  H HB3  . HIS A 1 64  ? -23.36530 50.85053 -3.45173  1.000 44.40961  ? 64  HIS A HB3  1 
ATOM   962  H HD2  . HIS A 1 64  ? -26.25697 48.53388 -3.95041  1.000 45.36183  ? 64  HIS A HD2  1 
ATOM   963  H HE1  . HIS A 1 64  ? -24.87578 49.46422 -7.54290  1.000 52.50639  ? 64  HIS A HE1  1 
ATOM   964  H HE2  . HIS A 1 64  ? -26.57956 48.34061 -6.34856  1.000 58.97500  ? 64  HIS A HE2  1 
ATOM   965  N N    . ASN A 1 65  ? -23.28089 46.65895 -3.24869  1.000 24.92029  ? 65  ASN A N    1 
ATOM   966  C CA   . ASN A 1 65  ? -23.82760 45.33259 -3.06330  1.000 21.20486  ? 65  ASN A CA   1 
ATOM   967  C C    . ASN A 1 65  ? -23.22483 44.59120 -1.85058  1.000 21.20461  ? 65  ASN A C    1 
ATOM   968  O O    . ASN A 1 65  ? -23.73120 43.52039 -1.51509  1.000 26.18654  ? 65  ASN A O    1 
ATOM   969  C CB   . ASN A 1 65  ? -23.57382 44.46180 -4.30433  1.000 25.18334  ? 65  ASN A CB   1 
ATOM   970  C CG   . ASN A 1 65  ? -24.24976 44.99508 -5.54742  1.000 36.00794  ? 65  ASN A CG   1 
ATOM   971  O OD1  . ASN A 1 65  ? -23.62247 45.10648 -6.59177  1.000 27.54947  ? 65  ASN A OD1  1 
ATOM   972  N ND2  . ASN A 1 65  ? -25.52532 45.33526 -5.43224  1.000 42.40249  ? 65  ASN A ND2  1 
ATOM   973  H H    . ASN A 1 65  ? -22.71295 46.71603 -3.89196  1.000 29.90435  ? 65  ASN A H    1 
ATOM   974  H HA   . ASN A 1 65  ? -24.78405 45.43171 -2.93571  1.000 25.44583  ? 65  ASN A HA   1 
ATOM   975  H HB2  . ASN A 1 65  ? -22.61957 44.42614 -4.47472  1.000 30.22001  ? 65  ASN A HB2  1 
ATOM   976  H HB3  . ASN A 1 65  ? -23.91475 43.56902 -4.13816  1.000 30.22001  ? 65  ASN A HB3  1 
ATOM   977  H HD21 . ASN A 1 65  ? -25.95129 45.64349 -6.11279  1.000 50.88299  ? 65  ASN A HD21 1 
ATOM   978  H HD22 . ASN A 1 65  ? -25.92717 45.24779 -4.67695  1.000 50.88299  ? 65  ASN A HD22 1 
ATOM   979  N N    . PHE A 1 66  ? -22.18427 45.12409 -1.24934  1.000 22.99944  ? 66  PHE A N    1 
ATOM   980  C CA   . PHE A 1 66  ? -21.55660 44.49960 -0.07188  1.000 25.76962  ? 66  PHE A CA   1 
ATOM   981  C C    . PHE A 1 66  ? -21.92753 45.30252 1.18269   1.000 26.63736  ? 66  PHE A C    1 
ATOM   982  O O    . PHE A 1 66  ? -21.52700 46.46028 1.33119   1.000 28.93547  ? 66  PHE A O    1 
ATOM   983  C CB   . PHE A 1 66  ? -20.04060 44.46549 -0.23898  1.000 22.43063  ? 66  PHE A CB   1 
ATOM   984  C CG   . PHE A 1 66  ? -19.57927 43.66332 -1.40420  1.000 22.68491  ? 66  PHE A CG   1 
ATOM   985  C CD1  . PHE A 1 66  ? -19.52130 42.28189 -1.33110  1.000 22.18356  ? 66  PHE A CD1  1 
ATOM   986  C CD2  . PHE A 1 66  ? -19.25015 44.27246 -2.60131  1.000 24.96621  ? 66  PHE A CD2  1 
ATOM   987  C CE1  . PHE A 1 66  ? -19.11296 41.54056 -2.42023  1.000 25.93620  ? 66  PHE A CE1  1 
ATOM   988  C CE2  . PHE A 1 66  ? -18.85348 43.53476 -3.70129  1.000 24.24594  ? 66  PHE A CE2  1 
ATOM   989  C CZ   . PHE A 1 66  ? -18.77832 42.16854 -3.61339  1.000 22.98882  ? 66  PHE A CZ   1 
ATOM   990  H H    . PHE A 1 66  ? -21.80838 45.85674 -1.49741  1.000 27.59933  ? 66  PHE A H    1 
ATOM   991  H HA   . PHE A 1 66  ? -21.89066 43.59498 0.03284   1.000 30.92354  ? 66  PHE A HA   1 
ATOM   992  H HB2  . PHE A 1 66  ? -19.72043 45.37309 -0.36003  1.000 26.91675  ? 66  PHE A HB2  1 
ATOM   993  H HB3  . PHE A 1 66  ? -19.64819 44.07899 0.55948   1.000 26.91675  ? 66  PHE A HB3  1 
ATOM   994  H HD1  . PHE A 1 66  ? -19.75934 41.85084 -0.54216  1.000 26.62027  ? 66  PHE A HD1  1 
ATOM   995  H HD2  . PHE A 1 66  ? -19.29668 45.19891 -2.66793  1.000 29.95945  ? 66  PHE A HD2  1 
ATOM   996  H HE1  . PHE A 1 66  ? -19.06133 40.61426 -2.35541  1.000 31.12344  ? 66  PHE A HE1  1 
ATOM   997  H HE2  . PHE A 1 66  ? -18.63842 43.96368 -4.49795  1.000 29.09513  ? 66  PHE A HE2  1 
ATOM   998  H HZ   . PHE A 1 66  ? -18.50541 41.66611 -4.34687  1.000 27.58659  ? 66  PHE A HZ   1 
ATOM   999  N N    . LEU A 1 67  ? -22.66212 44.67344 2.08091   1.000 25.12686  ? 67  LEU A N    1 
ATOM   1000 C CA   . LEU A 1 67  ? -23.01966 45.27260 3.35783   1.000 24.64483  ? 67  LEU A CA   1 
ATOM   1001 C C    . LEU A 1 67  ? -22.13734 44.65848 4.44151   1.000 22.83785  ? 67  LEU A C    1 
ATOM   1002 O O    . LEU A 1 67  ? -22.15625 43.43842 4.61978   1.000 25.89435  ? 67  LEU A O    1 
ATOM   1003 C CB   . LEU A 1 67  ? -24.49241 45.00212 3.65205   1.000 30.93425  ? 67  LEU A CB   1 
ATOM   1004 C CG   . LEU A 1 67  ? -25.43227 45.63993 2.63341   1.000 39.90917  ? 67  LEU A CG   1 
ATOM   1005 C CD1  . LEU A 1 67  ? -26.84733 45.08929 2.76309   1.000 50.10671  ? 67  LEU A CD1  1 
ATOM   1006 C CD2  . LEU A 1 67  ? -25.41174 47.15665 2.78110   1.000 53.48938  ? 67  LEU A CD2  1 
ATOM   1007 H H    . LEU A 1 67  ? -22.97415 43.87925 1.97365   1.000 30.15224  ? 67  LEU A H    1 
ATOM   1008 H HA   . LEU A 1 67  ? -22.86861 46.23065 3.34261   1.000 29.57380  ? 67  LEU A HA   1 
ATOM   1009 H HB2  . LEU A 1 67  ? -24.64390 44.04409 3.64090   1.000 37.12110  ? 67  LEU A HB2  1 
ATOM   1010 H HB3  . LEU A 1 67  ? -24.70908 45.36212 4.52632   1.000 37.12110  ? 67  LEU A HB3  1 
ATOM   1011 H HG   . LEU A 1 67  ? -25.12673 45.41914 1.73965   1.000 47.89100  ? 67  LEU A HG   1 
ATOM   1012 H HD11 . LEU A 1 67  ? -27.41758 45.52742 2.11212   1.000 60.12805  ? 67  LEU A HD11 1 
ATOM   1013 H HD12 . LEU A 1 67  ? -26.83065 44.13357 2.59812   1.000 60.12805  ? 67  LEU A HD12 1 
ATOM   1014 H HD13 . LEU A 1 67  ? -27.17347 45.26457 3.65964   1.000 60.12805  ? 67  LEU A HD13 1 
ATOM   1015 H HD21 . LEU A 1 67  ? -25.57437 47.38577 3.70951   1.000 64.18725  ? 67  LEU A HD21 1 
ATOM   1016 H HD22 . LEU A 1 67  ? -24.54309 47.48904 2.50564   1.000 64.18725  ? 67  LEU A HD22 1 
ATOM   1017 H HD23 . LEU A 1 67  ? -26.10498 47.53800 2.21995   1.000 64.18725  ? 67  LEU A HD23 1 
ATOM   1018 N N    . VAL A 1 68  ? -21.36293 45.50700 5.11597   1.000 21.42438  ? 68  VAL A N    1 
ATOM   1019 C CA   . VAL A 1 68  ? -20.41574 45.10284 6.14263   1.000 20.80345  ? 68  VAL A CA   1 
ATOM   1020 C C    . VAL A 1 68  ? -20.83803 45.73125 7.46622   1.000 30.57232  ? 68  VAL A C    1 
ATOM   1021 O O    . VAL A 1 68  ? -20.97202 46.95230 7.55662   1.000 26.03463  ? 68  VAL A O    1 
ATOM   1022 C CB   . VAL A 1 68  ? -18.98350 45.55456 5.77376   1.000 23.60776  ? 68  VAL A CB   1 
ATOM   1023 C CG1  . VAL A 1 68  ? -17.98766 45.13071 6.84942   1.000 29.42879  ? 68  VAL A CG1  1 
ATOM   1024 C CG2  . VAL A 1 68  ? -18.59265 44.97306 4.41218   1.000 25.13948  ? 68  VAL A CG2  1 
ATOM   1025 H H    . VAL A 1 68  ? -21.37195 46.35734 4.98777   1.000 25.70926  ? 68  VAL A H    1 
ATOM   1026 H HA   . VAL A 1 68  ? -20.43629 44.13806 6.24102   1.000 24.96415  ? 68  VAL A HA   1 
ATOM   1027 H HB   . VAL A 1 68  ? -18.95844 46.52257 5.71688   1.000 28.32932  ? 68  VAL A HB   1 
ATOM   1028 H HG11 . VAL A 1 68  ? -17.08857 45.32519 6.54167   1.000 35.31455  ? 68  VAL A HG11 1 
ATOM   1029 H HG12 . VAL A 1 68  ? -18.17276 45.62471 7.66342   1.000 35.31455  ? 68  VAL A HG12 1 
ATOM   1030 H HG13 . VAL A 1 68  ? -18.08336 44.17906 7.01102   1.000 35.31455  ? 68  VAL A HG13 1 
ATOM   1031 H HG21 . VAL A 1 68  ? -17.63875 45.09017 4.28083   1.000 30.16737  ? 68  VAL A HG21 1 
ATOM   1032 H HG22 . VAL A 1 68  ? -18.81532 44.02910 4.39625   1.000 30.16737  ? 68  VAL A HG22 1 
ATOM   1033 H HG23 . VAL A 1 68  ? -19.08207 45.44014 3.71706   1.000 30.16737  ? 68  VAL A HG23 1 
ATOM   1034 N N    . GLN A 1 69  ? -20.99010 44.89712 8.49715   1.000 27.02860  ? 69  GLN A N    1 
ATOM   1035 C CA   A GLN A 1 69  ? -21.41341 45.34102 9.82426   0.500 32.02360  ? 69  GLN A CA   1 
ATOM   1036 C CA   B GLN A 1 69  ? -21.41229 45.34195 9.82351   0.500 32.02260  ? 69  GLN A CA   1 
ATOM   1037 C C    . GLN A 1 69  ? -20.33861 44.95619 10.82972  1.000 29.32375  ? 69  GLN A C    1 
ATOM   1038 O O    . GLN A 1 69  ? -20.00239 43.77605 10.95134  1.000 21.99467  ? 69  GLN A O    1 
ATOM   1039 C CB   A GLN A 1 69  ? -22.73166 44.67098 10.23194  0.500 39.90548  ? 69  GLN A CB   1 
ATOM   1040 C CB   B GLN A 1 69  ? -22.73776 44.67598 10.20415  0.500 39.87454  ? 69  GLN A CB   1 
ATOM   1041 C CG   A GLN A 1 69  ? -23.74900 44.45930 9.11922   0.500 43.81685  ? 69  GLN A CG   1 
ATOM   1042 C CG   B GLN A 1 69  ? -23.48159 45.34118 11.35646  0.500 42.42232  ? 69  GLN A CG   1 
ATOM   1043 C CD   A GLN A 1 69  ? -24.86125 45.49176 9.11589   0.500 52.48590  ? 69  GLN A CD   1 
ATOM   1044 C CD   B GLN A 1 69  ? -24.51008 46.34521 10.87271  0.500 48.39358  ? 69  GLN A CD   1 
ATOM   1045 O OE1  A GLN A 1 69  ? -24.90407 46.38789 9.96275   0.500 54.81764  ? 69  GLN A OE1  1 
ATOM   1046 O OE1  B GLN A 1 69  ? -25.38598 46.01333 10.07311  0.500 53.60698  ? 69  GLN A OE1  1 
ATOM   1047 N NE2  A GLN A 1 69  ? -25.76921 45.37042 8.15193   0.500 50.20308  ? 69  GLN A NE2  1 
ATOM   1048 N NE2  B GLN A 1 69  ? -24.40485 47.58002 11.35198  0.500 45.09225  ? 69  GLN A NE2  1 
ATOM   1049 H H    . GLN A 1 69  ? -20.85005 44.05012 8.44630   1.000 32.43432  ? 69  GLN A H    1 
ATOM   1050 H HA   . GLN A 1 69  ? -21.52592 46.30443 9.81528   1.000 38.42712  ? 69  GLN A HA   1 
ATOM   1051 H HB2  A GLN A 1 69  ? -22.52572 43.79783 10.60087  0.500 47.88657  ? 69  GLN A HB2  1 
ATOM   1052 H HB2  B GLN A 1 69  ? -23.32338 44.69257 9.43105   0.500 47.84945  ? 69  GLN A HB2  1 
ATOM   1053 H HB3  A GLN A 1 69  ? -23.15633 45.22422 10.90609  0.500 47.88657  ? 69  GLN A HB3  1 
ATOM   1054 H HB3  B GLN A 1 69  ? -22.55762 43.75904 10.46427  0.500 47.84945  ? 69  GLN A HB3  1 
ATOM   1055 H HG2  A GLN A 1 69  ? -23.29380 44.50993 8.26416   0.500 52.58022  ? 69  GLN A HG2  1 
ATOM   1056 H HG2  B GLN A 1 69  ? -23.94260 44.66115 11.87215  0.500 50.90679  ? 69  GLN A HG2  1 
ATOM   1057 H HG3  A GLN A 1 69  ? -24.15514 43.58512 9.22760   0.500 52.58022  ? 69  GLN A HG3  1 
ATOM   1058 H HG3  B GLN A 1 69  ? -22.84424 45.80870 11.91870  0.500 50.90679  ? 69  GLN A HG3  1 
ATOM   1059 H HE21 A GLN A 1 69  ? -26.42153 45.92869 8.10288   0.500 60.24370  ? 69  GLN A HE21 1 
ATOM   1060 H HE21 B GLN A 1 69  ? -24.96471 48.18532 11.10753  0.500 54.11070  ? 69  GLN A HE21 1 
ATOM   1061 H HE22 A GLN A 1 69  ? -25.70408 44.73366 7.57756   0.500 60.24370  ? 69  GLN A HE22 1 
ATOM   1062 H HE22 B GLN A 1 69  ? -23.77687 47.77393 11.90665  0.500 54.11070  ? 69  GLN A HE22 1 
ATOM   1063 N N    . ALA A 1 70  ? -19.80930 45.93915 11.54775  1.000 27.35969  ? 70  ALA A N    1 
ATOM   1064 C CA   . ALA A 1 70  ? -18.83990 45.72445 12.63214  1.000 26.53579  ? 70  ALA A CA   1 
ATOM   1065 C C    . ALA A 1 70  ? -19.59454 45.98423 13.93135  1.000 38.46009  ? 70  ALA A C    1 
ATOM   1066 O O    . ALA A 1 70  ? -19.73804 47.13126 14.35767  1.000 32.33186  ? 70  ALA A O    1 
ATOM   1067 C CB   . ALA A 1 70  ? -17.62596 46.63444 12.49056  1.000 30.72678  ? 70  ALA A CB   1 
ATOM   1068 H H    . ALA A 1 70  ? -19.99871 46.76916 11.42607  1.000 32.83163  ? 70  ALA A H    1 
ATOM   1069 H HA   . ALA A 1 70  ? -18.51538 44.81049 12.61605  1.000 31.84295  ? 70  ALA A HA   1 
ATOM   1070 H HB1  . ALA A 1 70  ? -17.03721 46.49581 13.24888  1.000 36.87214  ? 70  ALA A HB1  1 
ATOM   1071 H HB2  . ALA A 1 70  ? -17.16190 46.41607 11.66723  1.000 36.87214  ? 70  ALA A HB2  1 
ATOM   1072 H HB3  . ALA A 1 70  ? -17.92399 47.55723 12.46753  1.000 36.87214  ? 70  ALA A HB3  1 
ATOM   1073 N N    . GLY A 1 71  ? -20.07160 44.91618 14.54929  1.000 41.37926  ? 71  GLY A N    1 
ATOM   1074 C CA   . GLY A 1 71  ? -20.97141 45.05176 15.67803  1.000 43.60459  ? 71  GLY A CA   1 
ATOM   1075 C C    . GLY A 1 71  ? -22.25625 45.71909 15.24367  1.000 43.54135  ? 71  GLY A C    1 
ATOM   1076 O O    . GLY A 1 71  ? -23.02122 45.15778 14.44981  1.000 48.54129  ? 71  GLY A O    1 
ATOM   1077 H H    . GLY A 1 71  ? -19.88919 44.10382 14.33389  1.000 49.65511  ? 71  GLY A H    1 
ATOM   1078 H HA2  . GLY A 1 71  ? -21.17808 44.17651 16.04152  1.000 52.32551  ? 71  GLY A HA2  1 
ATOM   1079 H HA3  . GLY A 1 71  ? -20.55448 45.59017 16.36882  1.000 52.32551  ? 71  GLY A HA3  1 
ATOM   1080 N N    . ASN A 1 72  ? -22.49896 46.92849 15.74738  1.000 39.30215  ? 72  ASN A N    1 
ATOM   1081 C CA   . ASN A 1 72  ? -23.68452 47.69712 15.38221  1.000 59.18361  ? 72  ASN A CA   1 
ATOM   1082 C C    . ASN A 1 72  ? -23.32063 48.93683 14.57282  1.000 54.93724  ? 72  ASN A C    1 
ATOM   1083 O O    . ASN A 1 72  ? -24.01502 49.95353 14.63695  1.000 62.17109  ? 72  ASN A O    1 
ATOM   1084 C CB   . ASN A 1 72  ? -24.48575 48.08071 16.63021  1.000 73.22269  ? 72  ASN A CB   1 
ATOM   1085 H H    . ASN A 1 72  ? -21.98445 47.32793 16.30892  1.000 47.16258  ? 72  ASN A H    1 
ATOM   1086 H HA   . ASN A 1 72  ? -24.25571 47.14149 14.82912  1.000 71.02033  ? 72  ASN A HA   1 
ATOM   1087 N N    . VAL A 1 73  ? -22.22223 48.87045 13.82221  1.000 38.46532  ? 73  VAL A N    1 
ATOM   1088 C CA   . VAL A 1 73  ? -21.76109 49.97799 12.99426  1.000 38.57055  ? 73  VAL A CA   1 
ATOM   1089 C C    . VAL A 1 73  ? -21.61306 49.48034 11.56610  1.000 42.27308  ? 73  VAL A C    1 
ATOM   1090 O O    . VAL A 1 73  ? -20.91140 48.49535 11.32023  1.000 34.19849  ? 73  VAL A O    1 
ATOM   1091 C CB   . VAL A 1 73  ? -20.42096 50.53726 13.49756  1.000 37.88339  ? 73  VAL A CB   1 
ATOM   1092 C CG1  . VAL A 1 73  ? -19.89141 51.58045 12.53027  1.000 48.19829  ? 73  VAL A CG1  1 
ATOM   1093 C CG2  . VAL A 1 73  ? -20.57321 51.11236 14.89626  1.000 50.01589  ? 73  VAL A CG2  1 
ATOM   1094 H H    . VAL A 1 73  ? -21.71680 48.17614 13.77660  1.000 46.15839  ? 73  VAL A H    1 
ATOM   1095 H HA   . VAL A 1 73  ? -22.42341 50.68654 13.00853  1.000 46.28466  ? 73  VAL A HA   1 
ATOM   1096 H HB   . VAL A 1 73  ? -19.77288 49.81713 13.54567  1.000 45.46007  ? 73  VAL A HB   1 
ATOM   1097 H HG11 . VAL A 1 73  ? -19.25304 52.14525 12.99328  1.000 57.83795  ? 73  VAL A HG11 1 
ATOM   1098 H HG12 . VAL A 1 73  ? -19.45810 51.13142 11.78763  1.000 57.83795  ? 73  VAL A HG12 1 
ATOM   1099 H HG13 . VAL A 1 73  ? -20.63258 52.11574 12.20620  1.000 57.83795  ? 73  VAL A HG13 1 
ATOM   1100 H HG21 . VAL A 1 73  ? -19.73767 51.52919 15.15900  1.000 60.01906  ? 73  VAL A HG21 1 
ATOM   1101 H HG22 . VAL A 1 73  ? -21.28452 51.77184 14.89085  1.000 60.01906  ? 73  VAL A HG22 1 
ATOM   1102 H HG23 . VAL A 1 73  ? -20.79234 50.39452 15.51074  1.000 60.01906  ? 73  VAL A HG23 1 
ATOM   1103 N N    . GLN A 1 74  ? -22.26049 50.16404 10.62802  1.000 40.66208  ? 74  GLN A N    1 
ATOM   1104 C CA   . GLN A 1 74  ? -22.11238 49.83690 9.21437   1.000 41.94534  ? 74  GLN A CA   1 
ATOM   1105 C C    . GLN A 1 74  ? -20.80465 50.40827 8.69537   1.000 47.79881  ? 74  GLN A C    1 
ATOM   1106 O O    . GLN A 1 74  ? -20.50850 51.58712 8.90699   1.000 43.69184  ? 74  GLN A O    1 
ATOM   1107 C CB   . GLN A 1 74  ? -23.27758 50.43097 8.42078   1.000 54.09051  ? 74  GLN A CB   1 
ATOM   1108 C CG   . GLN A 1 74  ? -24.47108 49.50299 8.25572   1.000 56.94333  ? 74  GLN A CG   1 
ATOM   1109 C CD   . GLN A 1 74  ? -24.36902 48.63362 7.00492   1.000 77.63335  ? 74  GLN A CD   1 
ATOM   1110 O OE1  . GLN A 1 74  ? -24.37620 47.40049 7.09240   1.000 67.96015  ? 74  GLN A OE1  1 
ATOM   1111 N NE2  . GLN A 1 74  ? -24.28342 49.27208 5.83411   1.000 59.98502  ? 74  GLN A NE2  1 
ATOM   1112 H H    . GLN A 1 74  ? -22.79167 50.82209 10.78428  1.000 48.79450  ? 74  GLN A H    1 
ATOM   1113 H HA   . GLN A 1 74  ? -22.10735 48.87397 9.09760   1.000 50.33441  ? 74  GLN A HA   1 
ATOM   1114 H HB2  . GLN A 1 74  ? -23.58797 51.22779 8.87864   1.000 64.90861  ? 74  GLN A HB2  1 
ATOM   1115 H HB3  . GLN A 1 74  ? -22.96082 50.66052 7.53316   1.000 64.90861  ? 74  GLN A HB3  1 
ATOM   1116 H HG2  . GLN A 1 74  ? -24.52503 48.91617 9.02620   1.000 68.33200  ? 74  GLN A HG2  1 
ATOM   1117 H HG3  . GLN A 1 74  ? -25.27907 50.03526 8.18686   1.000 68.33200  ? 74  GLN A HG3  1 
ATOM   1118 H HE21 . GLN A 1 74  ? -24.28759 50.13178 5.81182   1.000 71.98203  ? 74  GLN A HE21 1 
ATOM   1119 H HE22 . GLN A 1 74  ? -24.22417 48.82326 5.10291   1.000 71.98203  ? 74  GLN A HE22 1 
ATOM   1120 N N    . LEU A 1 75  ? -20.02171 49.57559 8.00759   1.000 29.28597  ? 75  LEU A N    1 
ATOM   1121 C CA   . LEU A 1 75  ? -18.80780 50.02922 7.35781   1.000 30.56798  ? 75  LEU A CA   1 
ATOM   1122 C C    . LEU A 1 75  ? -19.11585 50.26484 5.88320   1.000 33.72853  ? 75  LEU A C    1 
ATOM   1123 O O    . LEU A 1 75  ? -19.75914 49.43846 5.22990   1.000 43.55517  ? 75  LEU A O    1 
ATOM   1124 C CB   . LEU A 1 75  ? -17.68705 48.99869 7.46302   1.000 30.08410  ? 75  LEU A CB   1 
ATOM   1125 C CG   . LEU A 1 75  ? -17.24315 48.60209 8.87071   1.000 30.02599  ? 75  LEU A CG   1 
ATOM   1126 C CD1  . LEU A 1 75  ? -15.96123 47.75598 8.78676   1.000 37.52223  ? 75  LEU A CD1  1 
ATOM   1127 C CD2  . LEU A 1 75  ? -17.02095 49.80898 9.75131   1.000 33.52613  ? 75  LEU A CD2  1 
ATOM   1128 H H    . LEU A 1 75  ? -20.18047 48.73646 7.90639   1.000 35.14316  ? 75  LEU A H    1 
ATOM   1129 H HA   . LEU A 1 75  ? -18.50048 50.84656 7.78018   1.000 36.68157  ? 75  LEU A HA   1 
ATOM   1130 H HB2  . LEU A 1 75  ? -17.98374 48.18811 7.02049   1.000 36.10092  ? 75  LEU A HB2  1 
ATOM   1131 H HB3  . LEU A 1 75  ? -16.90763 49.35742 7.01058   1.000 36.10092  ? 75  LEU A HB3  1 
ATOM   1132 H HG   . LEU A 1 75  ? -17.94765 48.07799 9.28289   1.000 36.03119  ? 75  LEU A HG   1 
ATOM   1133 H HD11 . LEU A 1 75  ? -15.86173 47.25101 9.60896   1.000 45.02668  ? 75  LEU A HD11 1 
ATOM   1134 H HD12 . LEU A 1 75  ? -16.03174 47.14982 8.03277   1.000 45.02668  ? 75  LEU A HD12 1 
ATOM   1135 H HD13 . LEU A 1 75  ? -15.20070 48.34599 8.66685   1.000 45.02668  ? 75  LEU A HD13 1 
ATOM   1136 H HD21 . LEU A 1 75  ? -16.55722 49.53117 10.55672  1.000 40.23136  ? 75  LEU A HD21 1 
ATOM   1137 H HD22 . LEU A 1 75  ? -16.48553 50.45792 9.26850   1.000 40.23136  ? 75  LEU A HD22 1 
ATOM   1138 H HD23 . LEU A 1 75  ? -17.88072 50.19486 9.98107   1.000 40.23136  ? 75  LEU A HD23 1 
ATOM   1139 N N    . ARG A 1 76  ? -18.63090 51.38048 5.36702   1.000 30.89902  ? 76  ARG A N    1 
ATOM   1140 C CA   . ARG A 1 76  ? -18.83852 51.75149 3.97215   1.000 33.87402  ? 76  ARG A CA   1 
ATOM   1141 C C    . ARG A 1 76  ? -17.74158 51.12508 3.10919   1.000 22.69856  ? 76  ARG A C    1 
ATOM   1142 O O    . ARG A 1 76  ? -16.55539 51.41597 3.30183   1.000 27.18985  ? 76  ARG A O    1 
ATOM   1143 C CB   . ARG A 1 76  ? -18.80492 53.28025 3.85583   1.000 37.43466  ? 76  ARG A CB   1 
ATOM   1144 C CG   . ARG A 1 76  ? -19.14026 53.82655 2.46254   1.000 47.22588  ? 76  ARG A CG   1 
ATOM   1145 C CD   . ARG A 1 76  ? -18.46028 55.17844 2.26973   1.000 57.71564  ? 76  ARG A CD   1 
ATOM   1146 N NE   . ARG A 1 76  ? -18.60312 55.69553 0.91465   1.000 71.65060  ? 76  ARG A NE   1 
ATOM   1147 C CZ   . ARG A 1 76  ? -17.80856 56.61462 0.37941   1.000 91.01684  ? 76  ARG A CZ   1 
ATOM   1148 N NH1  . ARG A 1 76  ? -16.79059 57.12791 1.05442   1.000 88.18103  ? 76  ARG A NH1  1 
ATOM   1149 N NH2  . ARG A 1 76  ? -18.03477 57.02172 -0.86752  1.000 81.52160  ? 76  ARG A NH2  1 
ATOM   1150 H H    . ARG A 1 76  ? -18.16801 51.95351 5.81083   1.000 37.07882  ? 76  ARG A H    1 
ATOM   1151 H HA   . ARG A 1 76  ? -19.69283 51.41786 3.65631   1.000 40.64883  ? 76  ARG A HA   1 
ATOM   1152 H HB2  . ARG A 1 76  ? -19.45082 53.65052 4.47761   1.000 44.92160  ? 76  ARG A HB2  1 
ATOM   1153 H HB3  . ARG A 1 76  ? -17.91291 53.58665 4.08242   1.000 44.92160  ? 76  ARG A HB3  1 
ATOM   1154 H HG2  . ARG A 1 76  ? -18.81845 53.21405 1.78270   1.000 56.67106  ? 76  ARG A HG2  1 
ATOM   1155 H HG3  . ARG A 1 76  ? -20.09941 53.94310 2.37687   1.000 56.67106  ? 76  ARG A HG3  1 
ATOM   1156 H HD2  . ARG A 1 76  ? -18.85652 55.82111 2.87871   1.000 69.25876  ? 76  ARG A HD2  1 
ATOM   1157 H HD3  . ARG A 1 76  ? -17.51296 55.08506 2.45621   1.000 69.25876  ? 76  ARG A HD3  1 
ATOM   1158 H HE   . ARG A 1 76  ? -19.24298 55.38549 0.43086   1.000 85.98072  ? 76  ARG A HE   1 
ATOM   1159 H HH11 . ARG A 1 76  ? -16.63225 56.86660 1.85832   1.000 105.81724 ? 76  ARG A HH11 1 
ATOM   1160 H HH12 . ARG A 1 76  ? -16.28818 57.72239 0.68868   1.000 105.81724 ? 76  ARG A HH12 1 
ATOM   1161 H HH21 . ARG A 1 76  ? -18.68914 56.68988 -1.31616  1.000 97.82592  ? 76  ARG A HH21 1 
ATOM   1162 H HH22 . ARG A 1 76  ? -17.52655 57.61659 -1.22452  1.000 97.82592  ? 76  ARG A HH22 1 
ATOM   1163 N N    . VAL A 1 77  ? -18.15098 50.29517 2.16713   1.000 25.74824  ? 77  VAL A N    1 
ATOM   1164 C CA   . VAL A 1 77  ? -17.24377 49.67247 1.21380   1.000 25.15319  ? 77  VAL A CA   1 
ATOM   1165 C C    . VAL A 1 77  ? -16.92254 50.64852 0.08553   1.000 23.09702  ? 77  VAL A C    1 
ATOM   1166 O O    . VAL A 1 77  ? -17.83062 51.16518 -0.56895  1.000 30.80289  ? 77  VAL A O    1 
ATOM   1167 C CB   . VAL A 1 77  ? -17.86144 48.39418 0.64698   1.000 23.42479  ? 77  VAL A CB   1 
ATOM   1168 C CG1  . VAL A 1 77  ? -17.00150 47.82731 -0.45432  1.000 21.96732  ? 77  VAL A CG1  1 
ATOM   1169 C CG2  . VAL A 1 77  ? -18.05104 47.35539 1.76620   1.000 33.52370  ? 77  VAL A CG2  1 
ATOM   1170 H H    . VAL A 1 77  ? -18.97250 50.06782 2.05303   1.000 30.89789  ? 77  VAL A H    1 
ATOM   1171 H HA   . VAL A 1 77  ? -16.41736 49.45652 1.67349   1.000 30.18383  ? 77  VAL A HA   1 
ATOM   1172 H HB   . VAL A 1 77  ? -18.72970 48.60681 0.27043   1.000 28.10975  ? 77  VAL A HB   1 
ATOM   1173 H HG11 . VAL A 1 77  ? -17.27547 46.91360 -0.63032  1.000 26.36078  ? 77  VAL A HG11 1 
ATOM   1174 H HG12 . VAL A 1 77  ? -17.11500 48.36629 -1.25276  1.000 26.36078  ? 77  VAL A HG12 1 
ATOM   1175 H HG13 . VAL A 1 77  ? -16.07373 47.84586 -0.17182  1.000 26.36078  ? 77  VAL A HG13 1 
ATOM   1176 H HG21 . VAL A 1 77  ? -18.50186 46.57754 1.40205   1.000 40.22844  ? 77  VAL A HG21 1 
ATOM   1177 H HG22 . VAL A 1 77  ? -17.18112 47.10168 2.11227   1.000 40.22844  ? 77  VAL A HG22 1 
ATOM   1178 H HG23 . VAL A 1 77  ? -18.58689 47.74736 2.47340   1.000 40.22844  ? 77  VAL A HG23 1 
ATOM   1179 N N    . ILE A 1 78  ? -15.63043 50.88720 -0.13507  1.000 22.77153  ? 78  ILE A N    1 
ATOM   1180 C CA   . ILE A 1 78  ? -15.17267 51.84370 -1.13994  1.000 27.57666  ? 78  ILE A CA   1 
ATOM   1181 C C    . ILE A 1 78  ? -14.34894 51.20908 -2.24257  1.000 37.02717  ? 78  ILE A C    1 
ATOM   1182 O O    . ILE A 1 78  ? -13.93680 51.91117 -3.17421  1.000 29.39631  ? 78  ILE A O    1 
ATOM   1183 C CB   . ILE A 1 78  ? -14.40519 53.00654 -0.48691  1.000 27.21838  ? 78  ILE A CB   1 
ATOM   1184 C CG1  . ILE A 1 78  ? -13.17845 52.48231 0.26627   1.000 27.28516  ? 78  ILE A CG1  1 
ATOM   1185 C CG2  . ILE A 1 78  ? -15.31514 53.77429 0.44181   1.000 32.81011  ? 78  ILE A CG2  1 
ATOM   1186 C CD1  . ILE A 1 78  ? -12.21087 53.55127 0.72929   1.000 37.85664  ? 78  ILE A CD1  1 
ATOM   1187 H H    . ILE A 1 78  ? -14.99121 50.50119 0.29154   1.000 27.32584  ? 78  ILE A H    1 
ATOM   1188 H HA   . ILE A 1 78  ? -15.95539 52.21638 -1.57511  1.000 33.09200  ? 78  ILE A HA   1 
ATOM   1189 H HB   . ILE A 1 78  ? -14.09872 53.60585 -1.18533  1.000 32.66205  ? 78  ILE A HB   1 
ATOM   1190 H HG12 . ILE A 1 78  ? -13.48214 52.00355 1.05333   1.000 32.74219  ? 78  ILE A HG12 1 
ATOM   1191 H HG13 . ILE A 1 78  ? -12.69107 51.88219 -0.31958  1.000 32.74219  ? 78  ILE A HG13 1 
ATOM   1192 H HG21 . ILE A 1 78  ? -14.85302 54.56913 0.75096   1.000 39.37213  ? 78  ILE A HG21 1 
ATOM   1193 H HG22 . ILE A 1 78  ? -16.11892 54.02523 -0.03973  1.000 39.37213  ? 78  ILE A HG22 1 
ATOM   1194 H HG23 . ILE A 1 78  ? -15.54443 53.21023 1.19690   1.000 39.37213  ? 78  ILE A HG23 1 
ATOM   1195 H HD11 . ILE A 1 78  ? -12.67658 54.16483 1.31883   1.000 45.42796  ? 78  ILE A HD11 1 
ATOM   1196 H HD12 . ILE A 1 78  ? -11.47743 53.12934 1.20356   1.000 45.42796  ? 78  ILE A HD12 1 
ATOM   1197 H HD13 . ILE A 1 78  ? -11.87328 54.02839 -0.04484  1.000 45.42796  ? 78  ILE A HD13 1 
ATOM   1198 N N    . GLY A 1 79  ? -14.09325 49.90583 -2.17281  1.000 23.46425  ? 79  GLY A N    1 
ATOM   1199 C CA   . GLY A 1 79  ? -13.42632 49.21063 -3.24730  1.000 22.93770  ? 79  GLY A CA   1 
ATOM   1200 C C    . GLY A 1 79  ? -13.55984 47.72488 -3.01650  1.000 23.61589  ? 79  GLY A C    1 
ATOM   1201 O O    . GLY A 1 79  ? -13.82611 47.27807 -1.90453  1.000 22.44665  ? 79  GLY A O    1 
ATOM   1202 H H    . GLY A 1 79  ? -14.30044 49.40432 -1.50561  1.000 28.15709  ? 79  GLY A H    1 
ATOM   1203 H HA2  . GLY A 1 79  ? -13.83053 49.44095 -4.09846  1.000 27.52524  ? 79  GLY A HA2  1 
ATOM   1204 H HA3  . GLY A 1 79  ? -12.48632 49.44897 -3.26931  1.000 27.52524  ? 79  GLY A HA3  1 
ATOM   1205 N N    . HIS A 1 80  ? -13.44925 46.96991 -4.09314  1.000 20.46270  ? 80  HIS A N    1 
ATOM   1206 C CA   . HIS A 1 80  ? -13.51285 45.51090 -3.99650  1.000 20.84441  ? 80  HIS A CA   1 
ATOM   1207 C C    . HIS A 1 80  ? -12.57953 44.88574 -5.02300  1.000 29.75871  ? 80  HIS A C    1 
ATOM   1208 O O    . HIS A 1 80  ? -12.37879 45.41650 -6.13869  1.000 27.53983  ? 80  HIS A O    1 
ATOM   1209 C CB   . HIS A 1 80  ? -14.92180 44.97508 -4.14907  1.000 20.29707  ? 80  HIS A CB   1 
ATOM   1210 C CG   . HIS A 1 80  ? -15.55253 45.30309 -5.46980  1.000 26.71473  ? 80  HIS A CG   1 
ATOM   1211 N ND1  . HIS A 1 80  ? -16.05739 46.55078 -5.74845  1.000 30.82137  ? 80  HIS A ND1  1 
ATOM   1212 C CD2  . HIS A 1 80  ? -15.76428 44.54602 -6.57978  1.000 30.17636  ? 80  HIS A CD2  1 
ATOM   1213 C CE1  . HIS A 1 80  ? -16.53727 46.55888 -6.99004  1.000 36.35139  ? 80  HIS A CE1  1 
ATOM   1214 N NE2  . HIS A 1 80  ? -16.38108 45.35199 -7.51016  1.000 29.36459  ? 80  HIS A NE2  1 
ATOM   1215 H H    . HIS A 1 80  ? -13.33705 47.27030 -4.89112  1.000 24.55523  ? 80  HIS A H    1 
ATOM   1216 H HA   . HIS A 1 80  ? -13.19970 45.24803 -3.11688  1.000 25.01329  ? 80  HIS A HA   1 
ATOM   1217 H HB2  . HIS A 1 80  ? -14.89924 44.00914 -4.06339  1.000 24.35648  ? 80  HIS A HB2  1 
ATOM   1218 H HB3  . HIS A 1 80  ? -15.47803 45.35706 -3.45222  1.000 24.35648  ? 80  HIS A HB3  1 
ATOM   1219 H HD1  . HIS A 1 80  ? -16.06244 47.21916 -5.20731  1.000 36.98564  ? 80  HIS A HD1  1 
ATOM   1220 H HD2  . HIS A 1 80  ? -15.53529 43.65138 -6.68970  1.000 36.21163  ? 80  HIS A HD2  1 
ATOM   1221 H HE1  . HIS A 1 80  ? -16.91845 47.29015 -7.41998  1.000 43.62167  ? 80  HIS A HE1  1 
ATOM   1222 N N    . SER A 1 81  ? -12.00384 43.74236 -4.65265  1.000 20.92296  ? 81  SER A N    1 
ATOM   1223 C CA   . SER A 1 81  ? -11.14948 43.01184 -5.57584  1.000 19.12476  ? 81  SER A CA   1 
ATOM   1224 C C    . SER A 1 81  ? -11.11157 41.56090 -5.12328  1.000 20.79410  ? 81  SER A C    1 
ATOM   1225 O O    . SER A 1 81  ? -11.46279 41.25711 -3.97973  1.000 22.18202  ? 81  SER A O    1 
ATOM   1226 C CB   . SER A 1 81  ? -9.73166  43.57346 -5.62160  1.000 24.02889  ? 81  SER A CB   1 
ATOM   1227 O OG   . SER A 1 81  ? -9.10384  43.46728 -4.38839  1.000 28.00022  ? 81  SER A OG   1 
ATOM   1228 H H    . SER A 1 81  ? -12.09370 43.37587 -3.87986  1.000 25.10755  ? 81  SER A H    1 
ATOM   1229 H HA   . SER A 1 81  ? -11.52446 43.06978 -6.46855  1.000 22.94971  ? 81  SER A HA   1 
ATOM   1230 H HB2  . SER A 1 81  ? -9.21882  43.07659 -6.27812  1.000 28.83467  ? 81  SER A HB2  1 
ATOM   1231 H HB3  . SER A 1 81  ? -9.77335  44.50954 -5.87244  1.000 28.83467  ? 81  SER A HB3  1 
ATOM   1232 H HG   . SER A 1 81  ? -9.52588  43.90934 -3.81214  1.000 33.60026  ? 81  SER A HG   1 
ATOM   1233 N N    . MET A 1 82  ? -10.70131 40.68361 -6.01737  1.000 19.15081  ? 82  MET A N    1 
ATOM   1234 C CA   . MET A 1 82  ? -10.58423 39.26293 -5.76387  1.000 20.57507  ? 82  MET A CA   1 
ATOM   1235 C C    . MET A 1 82  ? -9.11783  38.89044 -5.73267  1.000 22.33728  ? 82  MET A C    1 
ATOM   1236 O O    . MET A 1 82  ? -8.33822  39.29740 -6.60778  1.000 23.53880  ? 82  MET A O    1 
ATOM   1237 C CB   . MET A 1 82  ? -11.32358 38.44995 -6.80814  1.000 23.03894  ? 82  MET A CB   1 
ATOM   1238 C CG   . MET A 1 82  ? -11.43166 37.01188 -6.51186  1.000 23.29465  ? 82  MET A CG   1 
ATOM   1239 S SD   . MET A 1 82  ? -12.59965 36.15752 -7.57050  1.000 28.27533  ? 82  MET A SD   1 
ATOM   1240 C CE   . MET A 1 82  ? -12.11998 36.75478 -9.20205  1.000 33.95758  ? 82  MET A CE   1 
ATOM   1241 H H    . MET A 1 82  ? -10.47360 40.89808 -6.81846  1.000 22.98098  ? 82  MET A H    1 
ATOM   1242 H HA   . MET A 1 82  ? -10.98467 39.05522 -4.90514  1.000 24.69008  ? 82  MET A HA   1 
ATOM   1243 H HB2  . MET A 1 82  ? -12.22491 38.79937 -6.88821  1.000 27.64673  ? 82  MET A HB2  1 
ATOM   1244 H HB3  . MET A 1 82  ? -10.85697 38.53881 -7.65388  1.000 27.64673  ? 82  MET A HB3  1 
ATOM   1245 H HG2  . MET A 1 82  ? -10.56213 36.59967 -6.63390  1.000 27.95358  ? 82  MET A HG2  1 
ATOM   1246 H HG3  . MET A 1 82  ? -11.72533 36.90134 -5.59401  1.000 27.95358  ? 82  MET A HG3  1 
ATOM   1247 H HE1  . MET A 1 82  ? -12.62765 36.27568 -9.87557  1.000 40.74910  ? 82  MET A HE1  1 
ATOM   1248 H HE2  . MET A 1 82  ? -12.30892 37.70450 -9.25882  1.000 40.74910  ? 82  MET A HE2  1 
ATOM   1249 H HE3  . MET A 1 82  ? -11.17122 36.59809 -9.32935  1.000 40.74910  ? 82  MET A HE3  1 
ATOM   1250 N N    . GLN A 1 83  ? -8.73894  38.11977 -4.71890  1.000 18.13450  ? 83  GLN A N    1 
ATOM   1251 C CA   . GLN A 1 83  ? -7.39542  37.53761 -4.63451  1.000 20.79235  ? 83  GLN A CA   1 
ATOM   1252 C C    . GLN A 1 83  ? -7.57590  36.02873 -4.42947  1.000 15.86020  ? 83  GLN A C    1 
ATOM   1253 O O    . GLN A 1 83  ? -7.89602  35.58635 -3.30876  1.000 17.09693  ? 83  GLN A O    1 
ATOM   1254 C CB   . GLN A 1 83  ? -6.57117  38.13448 -3.49283  1.000 28.84278  ? 83  GLN A CB   1 
ATOM   1255 C CG   . GLN A 1 83  ? -5.14701  37.55740 -3.47879  1.000 31.08037  ? 83  GLN A CG   1 
ATOM   1256 C CD   . GLN A 1 83  ? -4.20820  38.25834 -2.54446  1.000 45.25187  ? 83  GLN A CD   1 
ATOM   1257 O OE1  . GLN A 1 83  ? -4.48725  39.34746 -2.06532  1.000 41.79510  ? 83  GLN A OE1  1 
ATOM   1258 N NE2  . GLN A 1 83  ? -3.04649  37.64426 -2.31093  1.000 62.22619  ? 83  GLN A NE2  1 
ATOM   1259 H H    . GLN A 1 83  ? -9.24726  37.91451 -4.05627  1.000 21.76140  ? 83  GLN A H    1 
ATOM   1260 H HA   . GLN A 1 83  ? -6.92538  37.71166 -5.46497  1.000 24.95082  ? 83  GLN A HA   1 
ATOM   1261 H HB2  . GLN A 1 83  ? -6.51217  39.09597 -3.60662  1.000 34.61133  ? 83  GLN A HB2  1 
ATOM   1262 H HB3  . GLN A 1 83  ? -6.99570  37.92607 -2.64592  1.000 34.61133  ? 83  GLN A HB3  1 
ATOM   1263 H HG2  . GLN A 1 83  ? -5.19169  36.62732 -3.20702  1.000 37.29645  ? 83  GLN A HG2  1 
ATOM   1264 H HG3  . GLN A 1 83  ? -4.77616  37.62442 -4.37259  1.000 37.29645  ? 83  GLN A HG3  1 
ATOM   1265 H HE21 . GLN A 1 83  ? -2.87463  36.89111 -2.68886  1.000 74.67143  ? 83  GLN A HE21 1 
ATOM   1266 H HE22 . GLN A 1 83  ? -2.46976  38.00172 -1.78252  1.000 74.67143  ? 83  GLN A HE22 1 
ATOM   1267 N N    . ASN A 1 84  ? -7.39189  35.25222 -5.49990  1.000 16.51989  ? 84  ASN A N    1 
ATOM   1268 C CA   . ASN A 1 84  ? -7.55277  33.79720 -5.43712  1.000 15.09765  ? 84  ASN A CA   1 
ATOM   1269 C C    . ASN A 1 84  ? -8.96491  33.54281 -4.95577  1.000 17.00287  ? 84  ASN A C    1 
ATOM   1270 O O    . ASN A 1 84  ? -9.90078  34.10511 -5.53087  1.000 17.23174  ? 84  ASN A O    1 
ATOM   1271 C CB   . ASN A 1 84  ? -6.40773  33.18229 -4.62724  1.000 16.49485  ? 84  ASN A CB   1 
ATOM   1272 C CG   . ASN A 1 84  ? -5.05731  33.58670 -5.18419  1.000 14.27503  ? 84  ASN A CG   1 
ATOM   1273 O OD1  . ASN A 1 84  ? -4.82274  33.39865 -6.39588  1.000 19.38087  ? 84  ASN A OD1  1 
ATOM   1274 N ND2  . ASN A 1 84  ? -4.21733  34.14075 -4.37553  1.000 17.13236  ? 84  ASN A ND2  1 
ATOM   1275 H H    . ASN A 1 84  ? -7.17234  35.54713 -6.27734  1.000 19.82387  ? 84  ASN A H    1 
ATOM   1276 H HA   . ASN A 1 84  ? -7.47932  33.42248 -6.32879  1.000 18.11717  ? 84  ASN A HA   1 
ATOM   1277 H HB2  . ASN A 1 84  ? -6.46353  33.48823 -3.70844  1.000 19.79382  ? 84  ASN A HB2  1 
ATOM   1278 H HB3  . ASN A 1 84  ? -6.47453  32.21514 -4.65950  1.000 19.79382  ? 84  ASN A HB3  1 
ATOM   1279 H HD21 . ASN A 1 84  ? -3.44231  34.38218 -4.65954  1.000 20.55883  ? 84  ASN A HD21 1 
ATOM   1280 H HD22 . ASN A 1 84  ? -4.43276  34.26843 -3.55280  1.000 20.55883  ? 84  ASN A HD22 1 
ATOM   1281 N N    . CYS A 1 85  ? -9.18963  32.82635 -3.84277  1.000 13.89738  ? 85  CYS A N    1 
ATOM   1282 C CA   . CYS A 1 85  ? -10.54270 32.49968 -3.42959  1.000 13.26692  ? 85  CYS A CA   1 
ATOM   1283 C C    . CYS A 1 85  ? -11.06930 33.41270 -2.32495  1.000 17.48522  ? 85  CYS A C    1 
ATOM   1284 O O    . CYS A 1 85  ? -12.11649 33.08904 -1.76001  1.000 16.06448  ? 85  CYS A O    1 
ATOM   1285 C CB   . CYS A 1 85  ? -10.60993 31.01016 -3.00181  1.000 15.97847  ? 85  CYS A CB   1 
ATOM   1286 S SG   . CYS A 1 85  ? -10.22163 29.87602 -4.34451  1.000 18.85440  ? 85  CYS A SG   1 
ATOM   1287 H H    . CYS A 1 85  ? -8.57365  32.52626 -3.32305  1.000 16.67686  ? 85  CYS A H    1 
ATOM   1288 H HA   . CYS A 1 85  ? -11.13816 32.61540 -4.18651  1.000 15.92030  ? 85  CYS A HA   1 
ATOM   1289 H HB2  . CYS A 1 85  ? -9.97144  30.85864 -2.28748  1.000 19.17416  ? 85  CYS A HB2  1 
ATOM   1290 H HB3  . CYS A 1 85  ? -11.50750 30.81177 -2.69212  1.000 19.17416  ? 85  CYS A HB3  1 
ATOM   1291 H HG   . CYS A 1 85  ? -9.10391  30.08960 -4.72541  1.000 22.62528  ? 85  CYS A HG   1 
ATOM   1292 N N    . VAL A 1 86  ? -10.42491 34.54780 -2.05504  1.000 15.64566  ? 86  VAL A N    1 
ATOM   1293 C CA   . VAL A 1 86  ? -10.92808 35.49911 -1.08863  1.000 16.22364  ? 86  VAL A CA   1 
ATOM   1294 C C    . VAL A 1 86  ? -11.24980 36.80890 -1.80766  1.000 18.12190  ? 86  VAL A C    1 
ATOM   1295 O O    . VAL A 1 86  ? -10.70451 37.12544 -2.87544  1.000 18.31543  ? 86  VAL A O    1 
ATOM   1296 C CB   . VAL A 1 86  ? -10.04148 35.76739 0.13445   1.000 18.02867  ? 86  VAL A CB   1 
ATOM   1297 C CG1  . VAL A 1 86  ? -9.94094  34.45278 0.99274   1.000 19.54487  ? 86  VAL A CG1  1 
ATOM   1298 C CG2  . VAL A 1 86  ? -8.73672  36.25660 -0.25049  1.000 23.25152  ? 86  VAL A CG2  1 
ATOM   1299 H H    . VAL A 1 86  ? -9.68664  34.78415 -2.42746  1.000 18.77479  ? 86  VAL A H    1 
ATOM   1300 H HA   . VAL A 1 86  ? -11.73875 35.10345 -0.73202  1.000 19.46836  ? 86  VAL A HA   1 
ATOM   1301 H HB   . VAL A 1 86  ? -10.44031 36.46551 0.67709   1.000 21.63440  ? 86  VAL A HB   1 
ATOM   1302 H HG11 . VAL A 1 86  ? -9.20677  34.54089 1.62054   1.000 23.45385  ? 86  VAL A HG11 1 
ATOM   1303 H HG12 . VAL A 1 86  ? -10.77370 34.32502 1.47346   1.000 23.45385  ? 86  VAL A HG12 1 
ATOM   1304 H HG13 . VAL A 1 86  ? -9.78180  33.70076 0.40111   1.000 23.45385  ? 86  VAL A HG13 1 
ATOM   1305 H HG21 . VAL A 1 86  ? -8.69252  36.31066 -1.21797  1.000 27.90183  ? 86  VAL A HG21 1 
ATOM   1306 H HG22 . VAL A 1 86  ? -8.60236  37.13590 0.13642   1.000 27.90183  ? 86  VAL A HG22 1 
ATOM   1307 H HG23 . VAL A 1 86  ? -8.06021  35.64387 0.07783   1.000 27.90183  ? 86  VAL A HG23 1 
ATOM   1308 N N    . LEU A 1 87  ? -12.17980 37.54675 -1.23920  1.000 16.05594  ? 87  LEU A N    1 
ATOM   1309 C CA   . LEU A 1 87  ? -12.44683 38.92012 -1.63473  1.000 18.38567  ? 87  LEU A CA   1 
ATOM   1310 C C    . LEU A 1 87  ? -11.78845 39.86366 -0.65648  1.000 18.35320  ? 87  LEU A C    1 
ATOM   1311 O O    . LEU A 1 87  ? -11.69215 39.56425 0.55326   1.000 18.40256  ? 87  LEU A O    1 
ATOM   1312 C CB   . LEU A 1 87  ? -13.93587 39.21419 -1.62538  1.000 19.96464  ? 87  LEU A CB   1 
ATOM   1313 C CG   . LEU A 1 87  ? -14.88566 38.70953 -2.62925  1.000 26.99097  ? 87  LEU A CG   1 
ATOM   1314 C CD1  . LEU A 1 87  ? -16.24217 39.35170 -2.34560  1.000 28.35949  ? 87  LEU A CD1  1 
ATOM   1315 C CD2  . LEU A 1 87  ? -14.39963 38.99074 -4.05529  1.000 37.05715  ? 87  LEU A CD2  1 
ATOM   1316 H H    . LEU A 1 87  ? -12.68691 37.26955 -0.60233  1.000 19.26713  ? 87  LEU A H    1 
ATOM   1317 H HA   . LEU A 1 87  ? -12.09612 39.06153 -2.52799  1.000 22.06280  ? 87  LEU A HA   1 
ATOM   1318 H HB2  . LEU A 1 87  ? -14.27017 38.88535 -0.77626  1.000 23.95757  ? 87  LEU A HB2  1 
ATOM   1319 H HB3  . LEU A 1 87  ? -14.02010 40.17977 -1.66358  1.000 23.95757  ? 87  LEU A HB3  1 
ATOM   1320 H HG   . LEU A 1 87  ? -14.96806 37.74468 -2.57292  1.000 32.38917  ? 87  LEU A HG   1 
ATOM   1321 H HD11 . LEU A 1 87  ? -16.86025 39.10963 -3.05291  1.000 34.03139  ? 87  LEU A HD11 1 
ATOM   1322 H HD12 . LEU A 1 87  ? -16.57243 39.02849 -1.49275  1.000 34.03139  ? 87  LEU A HD12 1 
ATOM   1323 H HD13 . LEU A 1 87  ? -16.13523 40.31531 -2.31522  1.000 34.03139  ? 87  LEU A HD13 1 
ATOM   1324 H HD21 . LEU A 1 87  ? -13.60817 38.45785 -4.23002  1.000 44.46858  ? 87  LEU A HD21 1 
ATOM   1325 H HD22 . LEU A 1 87  ? -15.10230 38.75432 -4.68080  1.000 44.46858  ? 87  LEU A HD22 1 
ATOM   1326 H HD23 . LEU A 1 87  ? -14.18797 39.93387 -4.13658  1.000 44.46858  ? 87  LEU A HD23 1 
ATOM   1327 N N    . LYS A 1 88  ? -11.29186 40.98895 -1.15874  1.000 19.98192  ? 88  LYS A N    1 
ATOM   1328 C CA   . LYS A 1 88  ? -10.73258 42.06522 -0.35832  1.000 18.25817  ? 88  LYS A CA   1 
ATOM   1329 C C    . LYS A 1 88  ? -11.66329 43.26093 -0.54062  1.000 21.49282  ? 88  LYS A C    1 
ATOM   1330 O O    . LYS A 1 88  ? -11.80719 43.77150 -1.66813  1.000 21.83456  ? 88  LYS A O    1 
ATOM   1331 C CB   . LYS A 1 88  ? -9.30399  42.40709 -0.76160  1.000 21.61428  ? 88  LYS A CB   1 
ATOM   1332 C CG   . LYS A 1 88  ? -8.33683  41.25745 -0.52935  1.000 21.53529  ? 88  LYS A CG   1 
ATOM   1333 C CD   . LYS A 1 88  ? -6.92402  41.56089 -1.01384  1.000 28.88508  ? 88  LYS A CD   1 
ATOM   1334 C CE   . LYS A 1 88  ? -6.22632  42.59224 -0.16929  1.000 33.61572  ? 88  LYS A CE   1 
ATOM   1335 N NZ   . LYS A 1 88  ? -4.74394  42.61363 -0.41546  1.000 46.48144  ? 88  LYS A NZ   1 
ATOM   1336 H H    . LYS A 1 88  ? -11.26808 41.15736 -2.00175  1.000 23.97830  ? 88  LYS A H    1 
ATOM   1337 H HA   . LYS A 1 88  ? -10.70153 41.80145 0.57461   1.000 21.90980  ? 88  LYS A HA   1 
ATOM   1338 H HB2  . LYS A 1 88  ? -9.28680  42.62811 -1.70593  1.000 25.93714  ? 88  LYS A HB2  1 
ATOM   1339 H HB3  . LYS A 1 88  ? -9.00090  43.16521 -0.23787  1.000 25.93714  ? 88  LYS A HB3  1 
ATOM   1340 H HG2  . LYS A 1 88  ? -8.29251  41.06947 0.42123   1.000 25.84235  ? 88  LYS A HG2  1 
ATOM   1341 H HG3  . LYS A 1 88  ? -8.65501  40.47584 -1.00762  1.000 25.84235  ? 88  LYS A HG3  1 
ATOM   1342 H HD2  . LYS A 1 88  ? -6.39839  40.74612 -0.98618  1.000 34.66209  ? 88  LYS A HD2  1 
ATOM   1343 H HD3  . LYS A 1 88  ? -6.96678  41.89742 -1.92258  1.000 34.66209  ? 88  LYS A HD3  1 
ATOM   1344 H HE2  . LYS A 1 88  ? -6.58093  43.47016 -0.38003  1.000 40.33887  ? 88  LYS A HE2  1 
ATOM   1345 H HE3  . LYS A 1 88  ? -6.37473  42.39069 0.76786   1.000 40.33887  ? 88  LYS A HE3  1 
ATOM   1346 H HZ1  . LYS A 1 88  ? -4.40234  41.80186 -0.28724  1.000 55.77772  ? 88  LYS A HZ1  1 
ATOM   1347 H HZ2  . LYS A 1 88  ? -4.57793  42.86802 -1.25202  1.000 55.77772  ? 88  LYS A HZ2  1 
ATOM   1348 H HZ3  . LYS A 1 88  ? -4.35078  43.18400 0.14329   1.000 55.77772  ? 88  LYS A HZ3  1 
ATOM   1349 N N    . LEU A 1 89  ? -12.37034 43.64178 0.52134   1.000 20.74375  ? 89  LEU A N    1 
ATOM   1350 C CA   . LEU A 1 89  ? -13.29169 44.76493 0.50240   1.000 17.80768  ? 89  LEU A CA   1 
ATOM   1351 C C    . LEU A 1 89  ? -12.61348 45.93492 1.19202   1.000 25.01253  ? 89  LEU A C    1 
ATOM   1352 O O    . LEU A 1 89  ? -12.40166 45.91227 2.40881   1.000 24.49716  ? 89  LEU A O    1 
ATOM   1353 C CB   . LEU A 1 89  ? -14.61562 44.42070 1.16747   1.000 19.19902  ? 89  LEU A CB   1 
ATOM   1354 C CG   . LEU A 1 89  ? -15.36233 43.20870 0.66352   1.000 19.27159  ? 89  LEU A CG   1 
ATOM   1355 C CD1  . LEU A 1 89  ? -16.62098 42.96159 1.46762   1.000 27.41913  ? 89  LEU A CD1  1 
ATOM   1356 C CD2  . LEU A 1 89  ? -15.71919 43.41026 -0.83836  1.000 21.19611  ? 89  LEU A CD2  1 
ATOM   1357 H H    . LEU A 1 89  ? -12.32899 43.25010 1.28585   1.000 24.89250  ? 89  LEU A H    1 
ATOM   1358 H HA   . LEU A 1 89  ? -13.48433 45.00598 -0.41721  1.000 21.36922  ? 89  LEU A HA   1 
ATOM   1359 H HB2  . LEU A 1 89  ? -14.44241 44.27032 2.10996   1.000 23.03883  ? 89  LEU A HB2  1 
ATOM   1360 H HB3  . LEU A 1 89  ? -15.20839 45.18040 1.05618   1.000 23.03883  ? 89  LEU A HB3  1 
ATOM   1361 H HG   . LEU A 1 89  ? -14.79728 42.42628 0.76064   1.000 23.12591  ? 89  LEU A HG   1 
ATOM   1362 H HD11 . LEU A 1 89  ? -17.01881 42.12426 1.18213   1.000 32.90296  ? 89  LEU A HD11 1 
ATOM   1363 H HD12 . LEU A 1 89  ? -16.39037 42.91437 2.40863   1.000 32.90296  ? 89  LEU A HD12 1 
ATOM   1364 H HD13 . LEU A 1 89  ? -17.24142 43.69149 1.31533   1.000 32.90296  ? 89  LEU A HD13 1 
ATOM   1365 H HD21 . LEU A 1 89  ? -16.20820 44.24205 -0.93788  1.000 25.43533  ? 89  LEU A HD21 1 
ATOM   1366 H HD22 . LEU A 1 89  ? -14.89950 43.44449 -1.35588  1.000 25.43533  ? 89  LEU A HD22 1 
ATOM   1367 H HD23 . LEU A 1 89  ? -16.26705 42.66690 -1.13529  1.000 25.43533  ? 89  LEU A HD23 1 
ATOM   1368 N N    . LYS A 1 90  ? -12.25751 46.96752 0.42723   1.000 19.75918  ? 90  LYS A N    1 
ATOM   1369 C CA   . LYS A 1 90  ? -11.69114 48.16196 1.03185   1.000 19.86296  ? 90  LYS A CA   1 
ATOM   1370 C C    . LYS A 1 90  ? -12.82491 48.95244 1.68225   1.000 20.44980  ? 90  LYS A C    1 
ATOM   1371 O O    . LYS A 1 90  ? -13.88658 49.15452 1.06906   1.000 24.68258  ? 90  LYS A O    1 
ATOM   1372 C CB   . LYS A 1 90  ? -10.97384 49.02287 -0.01927  1.000 25.96366  ? 90  LYS A CB   1 
ATOM   1373 C CG   . LYS A 1 90  ? -9.93535  49.93657 0.58222   1.000 31.53680  ? 90  LYS A CG   1 
ATOM   1374 C CD   . LYS A 1 90  ? -9.43402  50.95576 -0.41947  1.000 43.94983  ? 90  LYS A CD   1 
ATOM   1375 C CE   . LYS A 1 90  ? -8.16696  51.63841 0.09000   1.000 65.65288  ? 90  LYS A CE   1 
ATOM   1376 N NZ   . LYS A 1 90  ? -7.85364  52.89901 -0.65333  1.000 65.82366  ? 90  LYS A NZ   1 
ATOM   1377 H H    . LYS A 1 90  ? -12.33433 46.99610 -0.42886  1.000 23.71101  ? 90  LYS A H    1 
ATOM   1378 H HA   . LYS A 1 90  ? -11.03313 47.91954 1.70203   1.000 23.83556  ? 90  LYS A HA   1 
ATOM   1379 H HB2  . LYS A 1 90  ? -10.52897 48.43985 -0.65416  1.000 31.15639  ? 90  LYS A HB2  1 
ATOM   1380 H HB3  . LYS A 1 90  ? -11.62885 49.57305 -0.47661  1.000 31.15639  ? 90  LYS A HB3  1 
ATOM   1381 H HG2  . LYS A 1 90  ? -10.32445 50.41373 1.33177   1.000 37.84416  ? 90  LYS A HG2  1 
ATOM   1382 H HG3  . LYS A 1 90  ? -9.17911  49.40815 0.88185   1.000 37.84416  ? 90  LYS A HG3  1 
ATOM   1383 H HD2  . LYS A 1 90  ? -9.22920  50.51265 -1.25768  1.000 52.73980  ? 90  LYS A HD2  1 
ATOM   1384 H HD3  . LYS A 1 90  ? -10.11363 51.63349 -0.55990  1.000 52.73980  ? 90  LYS A HD3  1 
ATOM   1385 H HE2  . LYS A 1 90  ? -8.28270  51.86290 1.02655   1.000 78.78345  ? 90  LYS A HE2  1 
ATOM   1386 H HE3  . LYS A 1 90  ? -7.41649  51.03300 -0.01575  1.000 78.78345  ? 90  LYS A HE3  1 
ATOM   1387 H HZ1  . LYS A 1 90  ? -7.08761  53.24353 -0.35905  1.000 78.98839  ? 90  LYS A HZ1  1 
ATOM   1388 H HZ2  . LYS A 1 90  ? -7.77822  52.72850 -1.52358  1.000 78.98839  ? 90  LYS A HZ2  1 
ATOM   1389 H HZ3  . LYS A 1 90  ? -8.50393  53.49420 -0.53092  1.000 78.98839  ? 90  LYS A HZ3  1 
ATOM   1390 N N    . VAL A 1 91  ? -12.61733 49.35276 2.93789   1.000 23.13759  ? 91  VAL A N    1 
ATOM   1391 C CA   . VAL A 1 91  ? -13.61556 50.10396 3.68938   1.000 25.44939  ? 91  VAL A CA   1 
ATOM   1392 C C    . VAL A 1 91  ? -13.02315 51.45185 4.08647   1.000 23.87026  ? 91  VAL A C    1 
ATOM   1393 O O    . VAL A 1 91  ? -11.81027 51.67039 4.04323   1.000 27.40473  ? 91  VAL A O    1 
ATOM   1394 C CB   . VAL A 1 91  ? -14.13055 49.32303 4.92070   1.000 24.85150  ? 91  VAL A CB   1 
ATOM   1395 C CG1  . VAL A 1 91  ? -14.95961 48.11097 4.45154   1.000 24.57027  ? 91  VAL A CG1  1 
ATOM   1396 C CG2  . VAL A 1 91  ? -12.99421 48.88956 5.82710   1.000 28.55434  ? 91  VAL A CG2  1 
ATOM   1397 H H    . VAL A 1 91  ? -11.89557 49.19767 3.37903   1.000 27.76511  ? 91  VAL A H    1 
ATOM   1398 H HA   . VAL A 1 91  ? -14.37880 50.28196 3.11782   1.000 30.53927  ? 91  VAL A HA   1 
ATOM   1399 H HB   . VAL A 1 91  ? -14.69745 49.90741 5.44797   1.000 29.82179  ? 91  VAL A HB   1 
ATOM   1400 H HG11 . VAL A 1 91  ? -15.29293 47.63635 5.22905   1.000 29.48433  ? 91  VAL A HG11 1 
ATOM   1401 H HG12 . VAL A 1 91  ? -15.70220 48.42582 3.91271   1.000 29.48433  ? 91  VAL A HG12 1 
ATOM   1402 H HG13 . VAL A 1 91  ? -14.39321 47.52587 3.92452   1.000 29.48433  ? 91  VAL A HG13 1 
ATOM   1403 H HG21 . VAL A 1 91  ? -13.35274 48.34272 6.54356   1.000 34.26521  ? 91  VAL A HG21 1 
ATOM   1404 H HG22 . VAL A 1 91  ? -12.35438 48.37723 5.30841   1.000 34.26521  ? 91  VAL A HG22 1 
ATOM   1405 H HG23 . VAL A 1 91  ? -12.56573 49.67799 6.19546   1.000 34.26521  ? 91  VAL A HG23 1 
ATOM   1406 N N    . ASP A 1 92  ? -13.90502 52.36832 4.47085   1.000 27.69302  ? 92  ASP A N    1 
ATOM   1407 C CA   . ASP A 1 92  ? -13.48278 53.75154 4.68979   1.000 32.40466  ? 92  ASP A CA   1 
ATOM   1408 C C    . ASP A 1 92  ? -12.88837 53.98505 6.06784   1.000 41.72184  ? 92  ASP A C    1 
ATOM   1409 O O    . ASP A 1 92  ? -12.45700 55.10688 6.35198   1.000 41.54961  ? 92  ASP A O    1 
ATOM   1410 C CB   . ASP A 1 92  ? -14.67021 54.71184 4.48351   1.000 39.16413  ? 92  ASP A CB   1 
ATOM   1411 C CG   . ASP A 1 92  ? -15.79506 54.47772 5.47697   1.000 49.72797  ? 92  ASP A CG   1 
ATOM   1412 O OD1  . ASP A 1 92  ? -15.67776 53.57140 6.33767   1.000 54.70136  ? 92  ASP A OD1  1 
ATOM   1413 O OD2  . ASP A 1 92  ? -16.80970 55.20117 5.39505   1.000 56.02295  ? 92  ASP A OD2  1 
ATOM   1414 H H    . ASP A 1 92  ? -14.74040 52.21858 4.60985   1.000 33.23162  ? 92  ASP A H    1 
ATOM   1415 H HA   . ASP A 1 92  ? -12.80362 53.96455 4.03080   1.000 38.88559  ? 92  ASP A HA   1 
ATOM   1416 H HB2  . ASP A 1 92  ? -14.36062 55.62484 4.59072   1.000 46.99695  ? 92  ASP A HB2  1 
ATOM   1417 H HB3  . ASP A 1 92  ? -15.02753 54.58537 3.59064   1.000 46.99695  ? 92  ASP A HB3  1 
ATOM   1418 N N    . THR A 1 93  ? -12.84518 52.95927 6.92121   1.000 33.59962  ? 93  THR A N    1 
ATOM   1419 C CA   . THR A 1 93  ? -12.35927 53.09142 8.28860   1.000 32.07131  ? 93  THR A CA   1 
ATOM   1420 C C    . THR A 1 93  ? -11.36793 51.96611 8.55851   1.000 30.16988  ? 93  THR A C    1 
ATOM   1421 O O    . THR A 1 93  ? -11.66896 50.80177 8.27284   1.000 27.96683  ? 93  THR A O    1 
ATOM   1422 C CB   . THR A 1 93  ? -13.52047 52.96423 9.27032   1.000 27.14803  ? 93  THR A CB   1 
ATOM   1423 O OG1  . THR A 1 93  ? -14.63321 53.75327 8.83184   1.000 48.50338  ? 93  THR A OG1  1 
ATOM   1424 C CG2  . THR A 1 93  ? -13.09176 53.41776 10.67104  1.000 42.56385  ? 93  THR A CG2  1 
ATOM   1425 H H    . THR A 1 93  ? -13.09826 52.16157 6.72316   1.000 40.31955  ? 93  THR A H    1 
ATOM   1426 H HA   . THR A 1 93  ? -11.91847 53.94742 8.40630   1.000 38.48557  ? 93  THR A HA   1 
ATOM   1427 H HB   . THR A 1 93  ? -13.79487 52.03502 9.31690   1.000 32.57763  ? 93  THR A HB   1 
ATOM   1428 H HG1  . THR A 1 93  ? -14.39487 54.55159 8.72475   1.000 58.20406  ? 93  THR A HG1  1 
ATOM   1429 H HG21 . THR A 1 93  ? -12.97282 54.38032 10.68617  1.000 51.07662  ? 93  THR A HG21 1 
ATOM   1430 H HG22 . THR A 1 93  ? -13.76967 53.17408 11.32062  1.000 51.07662  ? 93  THR A HG22 1 
ATOM   1431 H HG23 . THR A 1 93  ? -12.25453 52.99323 10.91544  1.000 51.07662  ? 93  THR A HG23 1 
ATOM   1432 N N    . ALA A 1 94  ? -10.19459 52.31943 9.08705   1.000 28.84928  ? 94  ALA A N    1 
ATOM   1433 C CA   . ALA A 1 94  ? -9.25351  51.32268 9.54213   1.000 31.27600  ? 94  ALA A CA   1 
ATOM   1434 C C    . ALA A 1 94  ? -9.72579  50.78282 10.88924  1.000 26.73872  ? 94  ALA A C    1 
ATOM   1435 O O    . ALA A 1 94  ? -10.20940 51.52665 11.74618  1.000 28.73418  ? 94  ALA A O    1 
ATOM   1436 C CB   . ALA A 1 94  ? -7.86435  51.92050 9.68543   1.000 28.20093  ? 94  ALA A CB   1 
ATOM   1437 H H    . ALA A 1 94  ? -9.92927  53.13114 9.18874   1.000 34.61914  ? 94  ALA A H    1 
ATOM   1438 H HA   . ALA A 1 94  ? -9.19480  50.59738 8.90072   1.000 37.53120  ? 94  ALA A HA   1 
ATOM   1439 H HB1  . ALA A 1 94  ? -7.89309  52.63181 10.34430  1.000 33.84112  ? 94  ALA A HB1  1 
ATOM   1440 H HB2  . ALA A 1 94  ? -7.25036  51.22712 9.97378   1.000 33.84112  ? 94  ALA A HB2  1 
ATOM   1441 H HB3  . ALA A 1 94  ? -7.58325  52.27540 8.82757   1.000 33.84112  ? 94  ALA A HB3  1 
ATOM   1442 N N    . ASN A 1 95  ? -9.62288  49.48289 11.06266  1.000 23.29971  ? 95  ASN A N    1 
ATOM   1443 C CA   . ASN A 1 95  ? -10.02645 48.87746 12.34025  1.000 23.01293  ? 95  ASN A CA   1 
ATOM   1444 C C    . ASN A 1 95  ? -9.08761  49.34282 13.43912  1.000 20.93549  ? 95  ASN A C    1 
ATOM   1445 O O    . ASN A 1 95  ? -7.89619  49.05345 13.40705  1.000 23.09711  ? 95  ASN A O    1 
ATOM   1446 C CB   . ASN A 1 95  ? -9.97889  47.36320 12.19531  1.000 23.02112  ? 95  ASN A CB   1 
ATOM   1447 C CG   . ASN A 1 95  ? -10.47241 46.65947 13.43986  1.000 25.89405  ? 95  ASN A CG   1 
ATOM   1448 O OD1  . ASN A 1 95  ? -10.80169 47.29708 14.45549  1.000 23.38300  ? 95  ASN A OD1  1 
ATOM   1449 N ND2  . ASN A 1 95  ? -10.53982 45.33844 13.37376  1.000 20.09815  ? 95  ASN A ND2  1 
ATOM   1450 H H    . ASN A 1 95  ? -9.32926  48.92815 10.47474  1.000 27.95965  ? 95  ASN A H    1 
ATOM   1451 H HA   . ASN A 1 95  ? -10.92768 49.14363 12.58074  1.000 27.61552  ? 95  ASN A HA   1 
ATOM   1452 H HB2  . ASN A 1 95  ? -10.54228 47.09595 11.45230  1.000 27.62535  ? 95  ASN A HB2  1 
ATOM   1453 H HB3  . ASN A 1 95  ? -9.06328  47.08677 12.03360  1.000 27.62535  ? 95  ASN A HB3  1 
ATOM   1454 H HD21 . ASN A 1 95  ? -10.81371 44.88734 14.05280  1.000 24.11778  ? 95  ASN A HD21 1 
ATOM   1455 H HD22 . ASN A 1 95  ? -10.30969 44.93173 12.65180  1.000 24.11778  ? 95  ASN A HD22 1 
ATOM   1456 N N    . PRO A 1 96  ? -9.58277  50.06156 14.44764  1.000 24.98793  ? 96  PRO A N    1 
ATOM   1457 C CA   . PRO A 1 96  ? -8.69062  50.52431 15.51755  1.000 28.65299  ? 96  PRO A CA   1 
ATOM   1458 C C    . PRO A 1 96  ? -8.18909  49.38927 16.40910  1.000 27.15482  ? 96  PRO A C    1 
ATOM   1459 O O    . PRO A 1 96  ? -7.21612  49.57634 17.15498  1.000 29.69012  ? 96  PRO A O    1 
ATOM   1460 C CB   . PRO A 1 96  ? -9.57297  51.50168 16.29948  1.000 26.43255  ? 96  PRO A CB   1 
ATOM   1461 C CG   . PRO A 1 96  ? -10.94536 51.03870 16.05823  1.000 28.15449  ? 96  PRO A CG   1 
ATOM   1462 C CD   . PRO A 1 96  ? -10.98860 50.46470 14.66065  1.000 26.24908  ? 96  PRO A CD   1 
ATOM   1463 H HA   . PRO A 1 96  ? -7.93245  51.00691 15.15263  1.000 34.38359  ? 96  PRO A HA   1 
ATOM   1464 H HB2  . PRO A 1 96  ? -9.35351  51.46383 17.24356  1.000 31.71907  ? 96  PRO A HB2  1 
ATOM   1465 H HB3  . PRO A 1 96  ? -9.44572  52.40332 15.96518  1.000 31.71907  ? 96  PRO A HB3  1 
ATOM   1466 H HG2  . PRO A 1 96  ? -11.17376 50.35797 16.71040  1.000 33.78539  ? 96  PRO A HG2  1 
ATOM   1467 H HG3  . PRO A 1 96  ? -11.55530 51.78908 16.13443  1.000 33.78539  ? 96  PRO A HG3  1 
ATOM   1468 H HD2  . PRO A 1 96  ? -11.58268 49.69926 14.61516  1.000 31.49890  ? 96  PRO A HD2  1 
ATOM   1469 H HD3  . PRO A 1 96  ? -11.26172 51.13545 14.01536  1.000 31.49890  ? 96  PRO A HD3  1 
ATOM   1470 N N    . LYS A 1 97  ? -8.81617  48.22638 16.32272  1.000 23.37014  ? 97  LYS A N    1 
ATOM   1471 C CA   . LYS A 1 97  ? -8.41830  47.06115 17.08951  1.000 25.18280  ? 97  LYS A CA   1 
ATOM   1472 C C    . LYS A 1 97  ? -7.48996  46.12856 16.32067  1.000 27.36918  ? 97  LYS A C    1 
ATOM   1473 O O    . LYS A 1 97  ? -7.29393  44.98914 16.75198  1.000 22.35540  ? 97  LYS A O    1 
ATOM   1474 C CB   . LYS A 1 97  ? -9.67326  46.32055 17.55111  1.000 23.79271  ? 97  LYS A CB   1 
ATOM   1475 C CG   . LYS A 1 97  ? -10.51519 47.11658 18.53829  1.000 31.40922  ? 97  LYS A CG   1 
ATOM   1476 C CD   . LYS A 1 97  ? -11.74612 46.32622 18.95687  1.000 34.18380  ? 97  LYS A CD   1 
ATOM   1477 C CE   . LYS A 1 97  ? -12.53000 47.05166 20.02350  1.000 52.25890  ? 97  LYS A CE   1 
ATOM   1478 N NZ   . LYS A 1 97  ? -13.67389 46.22141 20.50044  1.000 64.66000  ? 97  LYS A NZ   1 
ATOM   1479 H H    . LYS A 1 97  ? -9.49366  48.08521 15.81215  1.000 28.04417  ? 97  LYS A H    1 
ATOM   1480 H HA   . LYS A 1 97  ? -7.92730  47.34763 17.87548  1.000 30.21936  ? 97  LYS A HA   1 
ATOM   1481 H HB2  . LYS A 1 97  ? -10.22521 46.12689 16.77732  1.000 28.55125  ? 97  LYS A HB2  1 
ATOM   1482 H HB3  . LYS A 1 97  ? -9.40788  45.49432 17.98448  1.000 28.55125  ? 97  LYS A HB3  1 
ATOM   1483 H HG2  . LYS A 1 97  ? -9.98958  47.31035 19.33018  1.000 37.69107  ? 97  LYS A HG2  1 
ATOM   1484 H HG3  . LYS A 1 97  ? -10.80654 47.94335 18.12299  1.000 37.69107  ? 97  LYS A HG3  1 
ATOM   1485 H HD2  . LYS A 1 97  ? -12.32318 46.19833 18.18775  1.000 41.02057  ? 97  LYS A HD2  1 
ATOM   1486 H HD3  . LYS A 1 97  ? -11.47099 45.46644 19.31181  1.000 41.02057  ? 97  LYS A HD3  1 
ATOM   1487 H HE2  . LYS A 1 97  ? -11.95094 47.24021 20.77851  1.000 62.71068  ? 97  LYS A HE2  1 
ATOM   1488 H HE3  . LYS A 1 97  ? -12.88131 47.87951 19.65998  1.000 62.71068  ? 97  LYS A HE3  1 
ATOM   1489 H HZ1  . LYS A 1 97  ? -14.22264 46.04151 19.82323  1.000 77.59199  ? 97  LYS A HZ1  1 
ATOM   1490 H HZ2  . LYS A 1 97  ? -13.37342 45.45556 20.84000  1.000 77.59199  ? 97  LYS A HZ2  1 
ATOM   1491 H HZ3  . LYS A 1 97  ? -14.12587 46.65890 21.13006  1.000 77.59199  ? 97  LYS A HZ3  1 
ATOM   1492 N N    . THR A 1 98  ? -6.92455  46.57603 15.19887  1.000 27.83359  ? 98  THR A N    1 
ATOM   1493 C CA   . THR A 1 98  ? -6.05525  45.71237 14.40522  1.000 20.82975  ? 98  THR A CA   1 
ATOM   1494 C C    . THR A 1 98  ? -4.83015  45.31303 15.22372  1.000 23.17256  ? 98  THR A C    1 
ATOM   1495 O O    . THR A 1 98  ? -4.06519  46.18154 15.64333  1.000 23.64648  ? 98  THR A O    1 
ATOM   1496 C CB   . THR A 1 98  ? -5.59576  46.44691 13.12851  1.000 23.01242  ? 98  THR A CB   1 
ATOM   1497 O OG1  . THR A 1 98  ? -6.73679  46.84307 12.38103  1.000 24.27126  ? 98  THR A OG1  1 
ATOM   1498 C CG2  . THR A 1 98  ? -4.71749  45.53761 12.29938  1.000 24.15864  ? 98  THR A CG2  1 
ATOM   1499 H H    . THR A 1 98  ? -7.02837  47.36806 14.88028  1.000 33.40031  ? 98  THR A H    1 
ATOM   1500 H HA   . THR A 1 98  ? -6.54576  44.91515 14.15078  1.000 24.99570  ? 98  THR A HA   1 
ATOM   1501 H HB   . THR A 1 98  ? -5.08064  47.23608 13.35824  1.000 27.61491  ? 98  THR A HB   1 
ATOM   1502 H HG1  . THR A 1 98  ? -7.29275  46.21412 12.35043  1.000 29.12551  ? 98  THR A HG1  1 
ATOM   1503 H HG21 . THR A 1 98  ? -5.13334  44.66583 12.21003  1.000 28.99037  ? 98  THR A HG21 1 
ATOM   1504 H HG22 . THR A 1 98  ? -4.58799  45.91664 11.41594  1.000 28.99037  ? 98  THR A HG22 1 
ATOM   1505 H HG23 . THR A 1 98  ? -3.85297  45.43173 12.72632  1.000 28.99037  ? 98  THR A HG23 1 
ATOM   1506 N N    . PRO A 1 99  ? -4.59668  44.02239 15.45613  1.000 20.23134  ? 99  PRO A N    1 
ATOM   1507 C CA   . PRO A 1 99  ? -3.38288  43.59959 16.15227  1.000 20.77468  ? 99  PRO A CA   1 
ATOM   1508 C C    . PRO A 1 99  ? -2.20365  43.56404 15.19334  1.000 19.94246  ? 99  PRO A C    1 
ATOM   1509 O O    . PRO A 1 99  ? -2.36307  43.65507 13.99151  1.000 20.66011  ? 99  PRO A O    1 
ATOM   1510 C CB   . PRO A 1 99  ? -3.75547  42.17693 16.61511  1.000 22.28087  ? 99  PRO A CB   1 
ATOM   1511 C CG   . PRO A 1 99  ? -4.63075  41.67588 15.49716  1.000 24.00348  ? 99  PRO A CG   1 
ATOM   1512 C CD   . PRO A 1 99  ? -5.40970  42.86850 15.01168  1.000 24.51282  ? 99  PRO A CD   1 
ATOM   1513 H HA   . PRO A 1 99  ? -3.17854  44.16469 16.91372  1.000 24.92962  ? 99  PRO A HA   1 
ATOM   1514 H HB2  . PRO A 1 99  ? -2.95816  41.63304 16.71198  1.000 26.73704  ? 99  PRO A HB2  1 
ATOM   1515 H HB3  . PRO A 1 99  ? -4.23845  42.21029 17.45565  1.000 26.73704  ? 99  PRO A HB3  1 
ATOM   1516 H HG2  . PRO A 1 99  ? -4.07784  41.31519 14.78647  1.000 28.80418  ? 99  PRO A HG2  1 
ATOM   1517 H HG3  . PRO A 1 99  ? -5.22845  40.98977 15.83318  1.000 28.80418  ? 99  PRO A HG3  1 
ATOM   1518 H HD2  . PRO A 1 99  ? -5.48980  42.85643 14.04507  1.000 29.41538  ? 99  PRO A HD2  1 
ATOM   1519 H HD3  . PRO A 1 99  ? -6.29051  42.89205 15.41730  1.000 29.41538  ? 99  PRO A HD3  1 
ATOM   1520 N N    . LYS A 1 100 ? -1.00668  43.44725 15.74549  1.000 19.14483  ? 100 LYS A N    1 
ATOM   1521 C CA   . LYS A 1 100 ? 0.13302   43.02522 14.94126  1.000 20.06966  ? 100 LYS A CA   1 
ATOM   1522 C C    . LYS A 1 100 ? -0.23137  41.66377 14.36649  1.000 20.42551  ? 100 LYS A C    1 
ATOM   1523 O O    . LYS A 1 100 ? -0.73850  40.79291 15.09196  1.000 19.81594  ? 100 LYS A O    1 
ATOM   1524 C CB   . LYS A 1 100 ? 1.37519   42.87395 15.79672  1.000 24.90210  ? 100 LYS A CB   1 
ATOM   1525 C CG   . LYS A 1 100 ? 1.91747   44.16873 16.38691  1.000 47.35147  ? 100 LYS A CG   1 
ATOM   1526 C CD   . LYS A 1 100 ? 3.33539   43.92117 16.91954  1.000 70.88343  ? 100 LYS A CD   1 
ATOM   1527 C CE   . LYS A 1 100 ? 4.04136   45.20978 17.31309  1.000 89.66320  ? 100 LYS A CE   1 
ATOM   1528 N NZ   . LYS A 1 100 ? 5.46153   44.95311 17.70255  1.000 75.13525  ? 100 LYS A NZ   1 
ATOM   1529 H H    . LYS A 1 100 ? -0.82736  43.60357 16.57193  1.000 22.97379  ? 100 LYS A H    1 
ATOM   1530 H HA   . LYS A 1 100 ? 0.33158   43.67802 14.25183  1.000 24.08359  ? 100 LYS A HA   1 
ATOM   1531 H HB2  . LYS A 1 100 ? 1.16705   42.28266 16.53695  1.000 29.88252  ? 100 LYS A HB2  1 
ATOM   1532 H HB3  . LYS A 1 100 ? 2.07773   42.48750 15.25082  1.000 29.88252  ? 100 LYS A HB3  1 
ATOM   1533 H HG2  . LYS A 1 100 ? 1.95344   44.85467 15.70201  1.000 56.82177  ? 100 LYS A HG2  1 
ATOM   1534 H HG3  . LYS A 1 100 ? 1.35224   44.46045 17.11925  1.000 56.82177  ? 100 LYS A HG3  1 
ATOM   1535 H HD2  . LYS A 1 100 ? 3.28524   43.35377 17.70468  1.000 85.06012  ? 100 LYS A HD2  1 
ATOM   1536 H HD3  . LYS A 1 100 ? 3.86253   43.48782 16.23017  1.000 85.06012  ? 100 LYS A HD3  1 
ATOM   1537 H HE2  . LYS A 1 100 ? 4.03627   45.82233 16.56099  1.000 107.59584 ? 100 LYS A HE2  1 
ATOM   1538 H HE3  . LYS A 1 100 ? 3.58410   45.60935 18.06950  1.000 107.59584 ? 100 LYS A HE3  1 
ATOM   1539 H HZ1  . LYS A 1 100 ? 5.86035   45.71822 17.92084  1.000 90.16230  ? 100 LYS A HZ1  1 
ATOM   1540 H HZ2  . LYS A 1 100 ? 5.49083   44.40252 18.40119  1.000 90.16230  ? 100 LYS A HZ2  1 
ATOM   1541 H HZ3  . LYS A 1 100 ? 5.90102   44.58177 17.02353  1.000 90.16230  ? 100 LYS A HZ3  1 
ATOM   1542 N N    . TYR A 1 101 ? -0.02489  41.49364 13.05903  1.000 20.00528  ? 101 TYR A N    1 
ATOM   1543 C CA   . TYR A 1 101 ? -0.40363  40.21153 12.45133  1.000 17.95187  ? 101 TYR A CA   1 
ATOM   1544 C C    . TYR A 1 101 ? 0.49725   39.84761 11.29923  1.000 20.07845  ? 101 TYR A C    1 
ATOM   1545 O O    . TYR A 1 101 ? 1.26469   40.67155 10.77034  1.000 21.90518  ? 101 TYR A O    1 
ATOM   1546 C CB   . TYR A 1 101 ? -1.85182  40.25760 11.99505  1.000 18.00308  ? 101 TYR A CB   1 
ATOM   1547 C CG   . TYR A 1 101 ? -2.07673  41.12087 10.74649  1.000 17.97307  ? 101 TYR A CG   1 
ATOM   1548 C CD1  . TYR A 1 101 ? -2.33925  42.47285 10.85415  1.000 20.91867  ? 101 TYR A CD1  1 
ATOM   1549 C CD2  . TYR A 1 101 ? -2.01982  40.55591 9.49121   1.000 20.17338  ? 101 TYR A CD2  1 
ATOM   1550 C CE1  . TYR A 1 101 ? -2.54706  43.24399 9.73441   1.000 24.43629  ? 101 TYR A CE1  1 
ATOM   1551 C CE2  . TYR A 1 101 ? -2.21980  41.33641 8.34961   1.000 23.26104  ? 101 TYR A CE2  1 
ATOM   1552 C CZ   . TYR A 1 101 ? -2.48701  42.66770 8.48714   1.000 25.16578  ? 101 TYR A CZ   1 
ATOM   1553 O OH   . TYR A 1 101 ? -2.67569  43.46355 7.37092   1.000 28.53870  ? 101 TYR A OH   1 
ATOM   1554 H H    . TYR A 1 101 ? 0.31645   42.07616 12.52634  1.000 24.00634  ? 101 TYR A H    1 
ATOM   1555 H HA   . TYR A 1 101 ? -0.27996  39.51274 13.11261  1.000 21.54224  ? 101 TYR A HA   1 
ATOM   1556 H HB2  . TYR A 1 101 ? -2.14292  39.35570 11.78833  1.000 21.60370  ? 101 TYR A HB2  1 
ATOM   1557 H HB3  . TYR A 1 101 ? -2.39327  40.62505 12.71108  1.000 21.60370  ? 101 TYR A HB3  1 
ATOM   1558 H HD1  . TYR A 1 101 ? -2.37600  42.86715 11.69562  1.000 25.10240  ? 101 TYR A HD1  1 
ATOM   1559 H HD2  . TYR A 1 101 ? -1.84666  39.64646 9.40285   1.000 24.20805  ? 101 TYR A HD2  1 
ATOM   1560 H HE1  . TYR A 1 101 ? -2.72760  44.15223 9.82042   1.000 29.32355  ? 101 TYR A HE1  1 
ATOM   1561 H HE2  . TYR A 1 101 ? -2.17127  40.95233 7.50402   1.000 27.91325  ? 101 TYR A HE2  1 
ATOM   1562 H HH   . TYR A 1 101 ? -2.87150  44.24595 7.60569   1.000 34.24644  ? 101 TYR A HH   1 
ATOM   1563 N N    . LYS A 1 102 ? 0.39249   38.57145 10.93045  1.000 16.14595  ? 102 LYS A N    1 
ATOM   1564 C CA   . LYS A 1 102 ? 1.04216   38.02175 9.73310   1.000 16.55111  ? 102 LYS A CA   1 
ATOM   1565 C C    . LYS A 1 102 ? 0.06198   37.05304 9.08326   1.000 18.87600  ? 102 LYS A C    1 
ATOM   1566 O O    . LYS A 1 102 ? -0.82649  36.50034 9.73699   1.000 16.14170  ? 102 LYS A O    1 
ATOM   1567 C CB   . LYS A 1 102 ? 2.26982   37.16543 10.08385  1.000 19.54074  ? 102 LYS A CB   1 
ATOM   1568 C CG   . LYS A 1 102 ? 3.41447   37.83810 10.79318  1.000 25.23555  ? 102 LYS A CG   1 
ATOM   1569 C CD   . LYS A 1 102 ? 4.36000   36.78230 11.33769  1.000 31.71544  ? 102 LYS A CD   1 
ATOM   1570 C CE   . LYS A 1 102 ? 5.70497   37.36729 11.71018  1.000 47.90329  ? 102 LYS A CE   1 
ATOM   1571 N NZ   . LYS A 1 102 ? 6.47322   36.41590 12.55590  1.000 58.26353  ? 102 LYS A NZ   1 
ATOM   1572 H H    . LYS A 1 102 ? -0.06101  37.98553 11.36707  1.000 19.37514  ? 102 LYS A H    1 
ATOM   1573 H HA   . LYS A 1 102 ? 1.29222   38.75509 9.14950   1.000 19.86133  ? 102 LYS A HA   1 
ATOM   1574 H HB2  . LYS A 1 102 ? 1.97229   36.44237 10.65793  1.000 23.44889  ? 102 LYS A HB2  1 
ATOM   1575 H HB3  . LYS A 1 102 ? 2.62678   36.80661 9.25636   1.000 23.44889  ? 102 LYS A HB3  1 
ATOM   1576 H HG2  . LYS A 1 102 ? 3.89983   38.40378 10.17243  1.000 30.28267  ? 102 LYS A HG2  1 
ATOM   1577 H HG3  . LYS A 1 102 ? 3.07783   38.36882 11.53203  1.000 30.28267  ? 102 LYS A HG3  1 
ATOM   1578 H HD2  . LYS A 1 102 ? 3.97168   36.38467 12.13267  1.000 38.05853  ? 102 LYS A HD2  1 
ATOM   1579 H HD3  . LYS A 1 102 ? 4.50230   36.10128 10.66177  1.000 38.05853  ? 102 LYS A HD3  1 
ATOM   1580 H HE2  . LYS A 1 102 ? 6.21533   37.54616 10.90492  1.000 57.48395  ? 102 LYS A HE2  1 
ATOM   1581 H HE3  . LYS A 1 102 ? 5.57459   38.18855 12.20960  1.000 57.48395  ? 102 LYS A HE3  1 
ATOM   1582 H HZ1  . LYS A 1 102 ? 7.33286   36.64599 12.56898  1.000 69.91623  ? 102 LYS A HZ1  1 
ATOM   1583 H HZ2  . LYS A 1 102 ? 6.15873   36.42631 13.38843  1.000 69.91623  ? 102 LYS A HZ2  1 
ATOM   1584 H HZ3  . LYS A 1 102 ? 6.39991   35.59107 12.22975  1.000 69.91623  ? 102 LYS A HZ3  1 
ATOM   1585 N N    . PHE A 1 103 ? 0.22492   36.85403 7.76600   1.000 15.39509  ? 103 PHE A N    1 
ATOM   1586 C CA   . PHE A 1 103 ? -0.48138  35.80173 7.04156   1.000 16.29201  ? 103 PHE A CA   1 
ATOM   1587 C C    . PHE A 1 103 ? 0.54951   34.70945 6.76895   1.000 16.80203  ? 103 PHE A C    1 
ATOM   1588 O O    . PHE A 1 103 ? 1.50897   34.91992 6.00300   1.000 16.86040  ? 103 PHE A O    1 
ATOM   1589 C CB   . PHE A 1 103 ? -1.03308  36.32865 5.70365   1.000 16.31011  ? 103 PHE A CB   1 
ATOM   1590 C CG   . PHE A 1 103 ? -2.21378  37.26412 5.82696   1.000 15.15550  ? 103 PHE A CG   1 
ATOM   1591 C CD1  . PHE A 1 103 ? -2.86021  37.47963 7.04441   1.000 17.05011  ? 103 PHE A CD1  1 
ATOM   1592 C CD2  . PHE A 1 103 ? -2.70598  37.92854 4.70899   1.000 17.80598  ? 103 PHE A CD2  1 
ATOM   1593 C CE1  . PHE A 1 103 ? -3.96792  38.31395 7.11794   1.000 19.40424  ? 103 PHE A CE1  1 
ATOM   1594 C CE2  . PHE A 1 103 ? -3.79189  38.76568 4.77902   1.000 19.96438  ? 103 PHE A CE2  1 
ATOM   1595 C CZ   . PHE A 1 103 ? -4.44163  38.95697 6.00784   1.000 17.96144  ? 103 PHE A CZ   1 
ATOM   1596 H H    . PHE A 1 103 ? 0.74683   37.32482 7.27045   1.000 18.47411  ? 103 PHE A H    1 
ATOM   1597 H HA   . PHE A 1 103 ? -1.22053  35.46544 7.57210   1.000 19.55041  ? 103 PHE A HA   1 
ATOM   1598 H HB2  . PHE A 1 103 ? -0.32563  36.81107 5.24792   1.000 19.57213  ? 103 PHE A HB2  1 
ATOM   1599 H HB3  . PHE A 1 103 ? -1.31637  35.57112 5.16812   1.000 19.57213  ? 103 PHE A HB3  1 
ATOM   1600 H HD1  . PHE A 1 103 ? -2.54658  37.06095 7.81334   1.000 20.46013  ? 103 PHE A HD1  1 
ATOM   1601 H HD2  . PHE A 1 103 ? -2.28668  37.80194 3.88859   1.000 21.36718  ? 103 PHE A HD2  1 
ATOM   1602 H HE1  . PHE A 1 103 ? -4.39439  38.43736 7.93513   1.000 23.28509  ? 103 PHE A HE1  1 
ATOM   1603 H HE2  . PHE A 1 103 ? -4.09503  39.20337 4.01650   1.000 23.95726  ? 103 PHE A HE2  1 
ATOM   1604 H HZ   . PHE A 1 103 ? -5.18439  39.51353 6.06660   1.000 21.55373  ? 103 PHE A HZ   1 
ATOM   1605 N N    . VAL A 1 104 ? 0.36086   33.54931 7.36951   1.000 16.29759  ? 104 VAL A N    1 
ATOM   1606 C CA   . VAL A 1 104 ? 1.28037   32.42614 7.25052   1.000 17.24880  ? 104 VAL A CA   1 
ATOM   1607 C C    . VAL A 1 104 ? 0.45768   31.26772 6.70026   1.000 20.58330  ? 104 VAL A C    1 
ATOM   1608 O O    . VAL A 1 104 ? -0.77817  31.20392 6.86970   1.000 27.69675  ? 104 VAL A O    1 
ATOM   1609 C CB   . VAL A 1 104 ? 1.95471   32.05197 8.57272   1.000 16.82465  ? 104 VAL A CB   1 
ATOM   1610 C CG1  . VAL A 1 104 ? 2.63782   33.31155 9.18078   1.000 20.67610  ? 104 VAL A CG1  1 
ATOM   1611 C CG2  . VAL A 1 104 ? 0.95491   31.41299 9.49362   1.000 21.84549  ? 104 VAL A CG2  1 
ATOM   1612 H H    . VAL A 1 104 ? -0.31671  33.37855 7.87085   1.000 19.55711  ? 104 VAL A H    1 
ATOM   1613 H HA   . VAL A 1 104 ? 2.00082   32.64647 6.63953   1.000 20.69856  ? 104 VAL A HA   1 
ATOM   1614 H HB   . VAL A 1 104 ? 2.65421   31.39468 8.43284   1.000 20.18958  ? 104 VAL A HB   1 
ATOM   1615 H HG11 . VAL A 1 104 ? 3.31849   33.62900 8.56693   1.000 24.81132  ? 104 VAL A HG11 1 
ATOM   1616 H HG12 . VAL A 1 104 ? 1.96779   33.99972 9.31639   1.000 24.81132  ? 104 VAL A HG12 1 
ATOM   1617 H HG13 . VAL A 1 104 ? 3.04294   33.07258 10.02911  1.000 24.81132  ? 104 VAL A HG13 1 
ATOM   1618 H HG21 . VAL A 1 104 ? 1.32431   31.38468 10.39009  1.000 26.21458  ? 104 VAL A HG21 1 
ATOM   1619 H HG22 . VAL A 1 104 ? 0.13965   31.93854 9.48825   1.000 26.21458  ? 104 VAL A HG22 1 
ATOM   1620 H HG23 . VAL A 1 104 ? 0.77015   30.51269 9.18341   1.000 26.21458  ? 104 VAL A HG23 1 
ATOM   1621 N N    . ARG A 1 105 ? 1.10233   30.39223 5.95353   1.000 12.92998  ? 105 ARG A N    1 
ATOM   1622 C CA   . ARG A 1 105 ? 0.48815   29.15338 5.54323   1.000 11.60315  ? 105 ARG A CA   1 
ATOM   1623 C C    . ARG A 1 105 ? 1.10269   28.04730 6.37311   1.000 16.04814  ? 105 ARG A C    1 
ATOM   1624 O O    . ARG A 1 105 ? 2.32916   27.98010 6.51239   1.000 18.88993  ? 105 ARG A O    1 
ATOM   1625 C CB   . ARG A 1 105 ? 0.70915   28.89853 4.06731   1.000 14.42045  ? 105 ARG A CB   1 
ATOM   1626 C CG   . ARG A 1 105 ? -0.02535  27.69879 3.55155   1.000 13.64935  ? 105 ARG A CG   1 
ATOM   1627 C CD   . ARG A 1 105 ? 0.19051   27.56943 2.04119   1.000 12.99359  ? 105 ARG A CD   1 
ATOM   1628 N NE   . ARG A 1 105 ? -0.44737  26.36643 1.58027   1.000 13.20797  ? 105 ARG A NE   1 
ATOM   1629 C CZ   . ARG A 1 105 ? -1.64549  26.31757 0.99799   1.000 12.49400  ? 105 ARG A CZ   1 
ATOM   1630 N NH1  . ARG A 1 105 ? -2.39796  27.41189 0.87176   1.000 14.76820  ? 105 ARG A NH1  1 
ATOM   1631 N NH2  . ARG A 1 105 ? -2.08722  25.15673 0.55102   1.000 12.06268  ? 105 ARG A NH2  1 
ATOM   1632 H H    . ARG A 1 105 ? 1.90730   30.49806 5.66992   1.000 15.51597  ? 105 ARG A H    1 
ATOM   1633 H HA   . ARG A 1 105 ? -0.47009  29.17641 5.69203   1.000 13.92379  ? 105 ARG A HA   1 
ATOM   1634 H HB2  . ARG A 1 105 ? 0.40383   29.67160 3.56726   1.000 17.30454  ? 105 ARG A HB2  1 
ATOM   1635 H HB3  . ARG A 1 105 ? 1.65616   28.75635 3.91282   1.000 17.30454  ? 105 ARG A HB3  1 
ATOM   1636 H HG2  . ARG A 1 105 ? 0.30972   26.89804 3.98447   1.000 16.37922  ? 105 ARG A HG2  1 
ATOM   1637 H HG3  . ARG A 1 105 ? -0.97490  27.79652 3.72391   1.000 16.37922  ? 105 ARG A HG3  1 
ATOM   1638 H HD2  . ARG A 1 105 ? -0.20202  28.32989 1.58455   1.000 15.59231  ? 105 ARG A HD2  1 
ATOM   1639 H HD3  . ARG A 1 105 ? 1.13926   27.51861 1.84574   1.000 15.59231  ? 105 ARG A HD3  1 
ATOM   1640 H HE   . ARG A 1 105 ? -0.02556  25.62476 1.68796   1.000 15.84956  ? 105 ARG A HE   1 
ATOM   1641 H HH11 . ARG A 1 105 ? -2.11234  28.16675 1.16877   1.000 17.72184  ? 105 ARG A HH11 1 
ATOM   1642 H HH12 . ARG A 1 105 ? -3.16867  27.36250 0.49338   1.000 17.72184  ? 105 ARG A HH12 1 
ATOM   1643 H HH21 . ARG A 1 105 ? -1.60432  24.45046 0.63814   1.000 14.47522  ? 105 ARG A HH21 1 
ATOM   1644 H HH22 . ARG A 1 105 ? -2.85791  25.10671 0.17268   1.000 14.47522  ? 105 ARG A HH22 1 
ATOM   1645 N N    . ILE A 1 106 ? 0.28183   27.18904 6.94410   1.000 14.86759  ? 106 ILE A N    1 
ATOM   1646 C CA   . ILE A 1 106 ? 0.78887   26.13187 7.78473   1.000 16.96849  ? 106 ILE A CA   1 
ATOM   1647 C C    . ILE A 1 106 ? 0.96894   24.85492 6.97361   1.000 16.55963  ? 106 ILE A C    1 
ATOM   1648 O O    . ILE A 1 106 ? 0.49466   24.70683 5.85137   1.000 16.66602  ? 106 ILE A O    1 
ATOM   1649 C CB   . ILE A 1 106 ? -0.06733  25.88069 9.02673   1.000 18.94962  ? 106 ILE A CB   1 
ATOM   1650 C CG1  . ILE A 1 106 ? -1.44731  25.44763 8.63693   1.000 16.66223  ? 106 ILE A CG1  1 
ATOM   1651 C CG2  . ILE A 1 106 ? -0.00305  27.11042 9.93545   1.000 29.04233  ? 106 ILE A CG2  1 
ATOM   1652 C CD1  . ILE A 1 106 ? -2.22965  24.91362 9.84778   1.000 26.55260  ? 106 ILE A CD1  1 
ATOM   1653 H H    . ILE A 1 106 ? -0.57383  27.20004 6.85843   1.000 17.84111  ? 106 ILE A H    1 
ATOM   1654 H HA   . ILE A 1 106 ? 1.66393   26.41846 8.08975   1.000 20.36219  ? 106 ILE A HA   1 
ATOM   1655 H HB   . ILE A 1 106 ? 0.28248   25.13972 9.54586   1.000 22.73955  ? 106 ILE A HB   1 
ATOM   1656 H HG12 . ILE A 1 106 ? -1.92998  26.20497 8.27036   1.000 19.99468  ? 106 ILE A HG12 1 
ATOM   1657 H HG13 . ILE A 1 106 ? -1.38717  24.74082 7.97534   1.000 19.99468  ? 106 ILE A HG13 1 
ATOM   1658 H HG21 . ILE A 1 106 ? -0.23423  26.84713 10.83995  1.000 34.85080  ? 106 ILE A HG21 1 
ATOM   1659 H HG22 . ILE A 1 106 ? 0.89726   27.47091 9.91576   1.000 34.85080  ? 106 ILE A HG22 1 
ATOM   1660 H HG23 . ILE A 1 106 ? -0.63237  27.77449 9.61317   1.000 34.85080  ? 106 ILE A HG23 1 
ATOM   1661 H HD11 . ILE A 1 106 ? -1.96073  23.99740 10.01841  1.000 31.86312  ? 106 ILE A HD11 1 
ATOM   1662 H HD12 . ILE A 1 106 ? -2.03155  25.46582 10.62026  1.000 31.86312  ? 106 ILE A HD12 1 
ATOM   1663 H HD13 . ILE A 1 106 ? -3.17881  24.94855 9.65087   1.000 31.86312  ? 106 ILE A HD13 1 
ATOM   1664 N N    . GLN A 1 107 ? 1.68364   23.89240 7.58295   1.000 15.36782  ? 107 GLN A N    1 
ATOM   1665 C CA   . GLN A 1 107 ? 1.92880   22.57806 7.08842   1.000 14.23893  ? 107 GLN A CA   1 
ATOM   1666 C C    . GLN A 1 107 ? 0.99111   21.58050 7.71048   1.000 14.44240  ? 107 GLN A C    1 
ATOM   1667 O O    . GLN A 1 107 ? 0.62268   21.71785 8.89496   1.000 16.16688  ? 107 GLN A O    1 
ATOM   1668 C CB   . GLN A 1 107 ? 3.36440   22.15768 7.50804   1.000 19.54445  ? 107 GLN A CB   1 
ATOM   1669 C CG   . GLN A 1 107 ? 4.45732   22.83791 6.72859   1.000 20.39861  ? 107 GLN A CG   1 
ATOM   1670 C CD   . GLN A 1 107 ? 4.52527   22.34582 5.31162   1.000 19.23428  ? 107 GLN A CD   1 
ATOM   1671 O OE1  . GLN A 1 107 ? 4.37789   21.12441 5.06718   1.000 18.46436  ? 107 GLN A OE1  1 
ATOM   1672 N NE2  . GLN A 1 107 ? 4.68100   23.27807 4.36610   1.000 22.46271  ? 107 GLN A NE2  1 
ATOM   1673 H H    . GLN A 1 107 ? 2.05884   24.00966 8.34785   1.000 18.44138  ? 107 GLN A H    1 
ATOM   1674 H HA   . GLN A 1 107 ? 1.81776   22.56238 6.12493   1.000 17.08672  ? 107 GLN A HA   1 
ATOM   1675 H HB2  . GLN A 1 107 ? 3.49057   22.37650 8.44458   1.000 23.45334  ? 107 GLN A HB2  1 
ATOM   1676 H HB3  . GLN A 1 107 ? 3.45912   21.20152 7.37507   1.000 23.45334  ? 107 GLN A HB3  1 
ATOM   1677 H HG2  . GLN A 1 107 ? 4.28942   23.79309 6.71036   1.000 24.47833  ? 107 GLN A HG2  1 
ATOM   1678 H HG3  . GLN A 1 107 ? 5.31096   22.65916 7.15314   1.000 24.47833  ? 107 GLN A HG3  1 
ATOM   1679 H HE21 . GLN A 1 107 ? 4.73648   24.10781 4.58533   1.000 26.95525  ? 107 GLN A HE21 1 
ATOM   1680 H HE22 . GLN A 1 107 ? 4.72570   23.04803 3.53864   1.000 26.95525  ? 107 GLN A HE22 1 
ATOM   1681 N N    . PRO A 1 108 ? 0.66851   20.50107 7.01002   1.000 17.60215  ? 108 PRO A N    1 
ATOM   1682 C CA   . PRO A 1 108 ? 0.01393   19.37049 7.66164   1.000 18.81612  ? 108 PRO A CA   1 
ATOM   1683 C C    . PRO A 1 108 ? 0.78675   18.93690 8.88349   1.000 17.36552  ? 108 PRO A C    1 
ATOM   1684 O O    . PRO A 1 108 ? 2.02744   18.96194 8.92921   1.000 19.98290  ? 108 PRO A O    1 
ATOM   1685 C CB   . PRO A 1 108 ? 0.02251   18.28145 6.58040   1.000 23.03007  ? 108 PRO A CB   1 
ATOM   1686 C CG   . PRO A 1 108 ? 0.02371   19.04519 5.30680   1.000 22.74113  ? 108 PRO A CG   1 
ATOM   1687 C CD   . PRO A 1 108 ? 0.86921   20.27253 5.55290   1.000 14.18855  ? 108 PRO A CD   1 
ATOM   1688 H HA   . PRO A 1 108 ? -0.90043  19.58868 7.90088   1.000 22.57935  ? 108 PRO A HA   1 
ATOM   1689 H HB2  . PRO A 1 108 ? 0.81920   17.73425 6.66267   1.000 27.63609  ? 108 PRO A HB2  1 
ATOM   1690 H HB3  . PRO A 1 108 ? -0.76993  17.72733 6.65702   1.000 27.63609  ? 108 PRO A HB3  1 
ATOM   1691 H HG2  . PRO A 1 108 ? 0.40708   18.50126 4.60106   1.000 27.28936  ? 108 PRO A HG2  1 
ATOM   1692 H HG3  . PRO A 1 108 ? -0.88456  19.29577 5.07628   1.000 27.28936  ? 108 PRO A HG3  1 
ATOM   1693 H HD2  . PRO A 1 108 ? 1.80229   20.10096 5.35084   1.000 17.02627  ? 108 PRO A HD2  1 
ATOM   1694 H HD3  . PRO A 1 108 ? 0.55050   21.02699 5.03318   1.000 17.02627  ? 108 PRO A HD3  1 
ATOM   1695 N N    . GLY A 1 109 ? 0.04622   18.60543 9.93594   1.000 15.65260  ? 109 GLY A N    1 
ATOM   1696 C CA   . GLY A 1 109 ? 0.61743   18.24979 11.21495  1.000 16.02500  ? 109 GLY A CA   1 
ATOM   1697 C C    . GLY A 1 109 ? 0.70115   19.38468 12.20928  1.000 16.39220  ? 109 GLY A C    1 
ATOM   1698 O O    . GLY A 1 109 ? 0.87192   19.13018 13.40969  1.000 20.76120  ? 109 GLY A O    1 
ATOM   1699 H H    . GLY A 1 109 ? -0.81337  18.58066 9.92635   1.000 18.78312  ? 109 GLY A H    1 
ATOM   1700 H HA2  . GLY A 1 109 ? 0.07843   17.54775 11.61183  1.000 19.23000  ? 109 GLY A HA2  1 
ATOM   1701 H HA3  . GLY A 1 109 ? 1.51645   17.91491 11.07170  1.000 19.23000  ? 109 GLY A HA3  1 
ATOM   1702 N N    . GLN A 1 110 ? 0.58885   20.63284 11.76913  1.000 13.85363  ? 110 GLN A N    1 
ATOM   1703 C CA   A GLN A 1 110 ? 0.62044   21.79802 12.63032  0.500 15.18588  ? 110 GLN A CA   1 
ATOM   1704 C CA   B GLN A 1 110 ? 0.62402   21.77850 12.64760  0.500 15.19685  ? 110 GLN A CA   1 
ATOM   1705 C C    . GLN A 1 110 ? -0.77999  22.10186 13.16867  1.000 15.94873  ? 110 GLN A C    1 
ATOM   1706 O O    . GLN A 1 110 ? -1.78564  21.76634 12.55957  1.000 16.32761  ? 110 GLN A O    1 
ATOM   1707 C CB   A GLN A 1 110 ? 1.13021   23.04040 11.89595  0.500 17.88744  ? 110 GLN A CB   1 
ATOM   1708 C CB   B GLN A 1 110 ? 1.28700   22.97180 11.98123  0.500 18.34775  ? 110 GLN A CB   1 
ATOM   1709 C CG   A GLN A 1 110 ? 2.63023   23.08850 11.53198  0.500 22.24754  ? 110 GLN A CG   1 
ATOM   1710 C CG   B GLN A 1 110 ? 2.77728   22.70309 11.65458  0.500 17.19246  ? 110 GLN A CG   1 
ATOM   1711 C CD   A GLN A 1 110 ? 3.06453   24.49815 11.02873  0.500 25.92628  ? 110 GLN A CD   1 
ATOM   1712 C CD   B GLN A 1 110 ? 3.61914   22.27795 12.85603  0.500 23.07183  ? 110 GLN A CD   1 
ATOM   1713 O OE1  A GLN A 1 110 ? 3.29966   24.73892 9.82654   0.500 12.16179  ? 110 GLN A OE1  1 
ATOM   1714 O OE1  B GLN A 1 110 ? 4.09314   21.13591 12.92682  0.500 26.77029  ? 110 GLN A OE1  1 
ATOM   1715 N NE2  A GLN A 1 110 ? 3.17161   25.43792 11.97242  0.500 31.71759  ? 110 GLN A NE2  1 
ATOM   1716 N NE2  B GLN A 1 110 ? 3.79286   23.18489 13.81460  0.500 24.54396  ? 110 GLN A NE2  1 
ATOM   1717 H H    . GLN A 1 110 ? 0.48931   20.83446 10.93905  1.000 16.62436  ? 110 GLN A H    1 
ATOM   1718 H HA   . GLN A 1 110 ? 1.22528   21.60753 13.36433  1.000 18.23622  ? 110 GLN A HA   1 
ATOM   1719 H HB2  A GLN A 1 110 ? 0.63763   23.11672 11.06382  0.500 21.46493  ? 110 GLN A HB2  1 
ATOM   1720 H HB2  B GLN A 1 110 ? 0.82560   23.16977 11.15128  0.500 22.01731  ? 110 GLN A HB2  1 
ATOM   1721 H HB3  A GLN A 1 110 ? 0.95363   23.81108 12.45788  0.500 21.46493  ? 110 GLN A HB3  1 
ATOM   1722 H HB3  B GLN A 1 110 ? 1.24019   23.73570 12.57720  0.500 22.01731  ? 110 GLN A HB3  1 
ATOM   1723 H HG2  A GLN A 1 110 ? 3.15616   22.87192 12.31772  0.500 26.69705  ? 110 GLN A HG2  1 
ATOM   1724 H HG2  B GLN A 1 110 ? 2.82693   21.99277 10.99589  0.500 20.63096  ? 110 GLN A HG2  1 
ATOM   1725 H HG3  A GLN A 1 110 ? 2.80797   22.44685 10.82658  0.500 26.69705  ? 110 GLN A HG3  1 
ATOM   1726 H HG3  B GLN A 1 110 ? 3.16737   23.51569 11.29624  0.500 20.63096  ? 110 GLN A HG3  1 
ATOM   1727 H HE21 A GLN A 1 110 ? 3.00460   25.24387 12.79342  0.500 38.06111  ? 110 GLN A HE21 1 
ATOM   1728 H HE21 B GLN A 1 110 ? 3.43844   23.96471 13.73808  0.500 29.45275  ? 110 GLN A HE21 1 
ATOM   1729 H HE22 A GLN A 1 110 ? 3.40754   26.23687 11.75882  0.500 38.06111  ? 110 GLN A HE22 1 
ATOM   1730 H HE22 B GLN A 1 110 ? 4.25953   22.99106 14.51048  0.500 29.45275  ? 110 GLN A HE22 1 
ATOM   1731 N N    . THR A 1 111 ? -0.82619  22.76409 14.33107  1.000 14.80504  ? 111 THR A N    1 
ATOM   1732 C CA   . THR A 1 111 ? -2.09554  23.09748 14.95416  1.000 13.52740  ? 111 THR A CA   1 
ATOM   1733 C C    . THR A 1 111 ? -2.36066  24.59311 14.92974  1.000 15.50379  ? 111 THR A C    1 
ATOM   1734 O O    . THR A 1 111 ? -1.47972  25.41235 14.72963  1.000 16.49522  ? 111 THR A O    1 
ATOM   1735 C CB   . THR A 1 111 ? -2.12116  22.59992 16.42831  1.000 16.08560  ? 111 THR A CB   1 
ATOM   1736 O OG1  . THR A 1 111 ? -1.01141  23.18016 17.07403  1.000 17.35353  ? 111 THR A OG1  1 
ATOM   1737 C CG2  . THR A 1 111 ? -2.06045  21.07004 16.43528  1.000 16.36809  ? 111 THR A CG2  1 
ATOM   1738 H H    . THR A 1 111 ? -0.13406  23.02601 14.76920  1.000 17.76605  ? 111 THR A H    1 
ATOM   1739 H HA   . THR A 1 111 ? -2.80504  22.66811 14.45103  1.000 16.23288  ? 111 THR A HA   1 
ATOM   1740 H HB   . THR A 1 111 ? -2.92811  22.85003 16.90492  1.000 19.30272  ? 111 THR A HB   1 
ATOM   1741 H HG1  . THR A 1 111 ? -0.83823  22.76025 17.78063  1.000 20.82423  ? 111 THR A HG1  1 
ATOM   1742 H HG21 . THR A 1 111 ? -1.97949  20.74538 17.34575  1.000 19.64171  ? 111 THR A HG21 1 
ATOM   1743 H HG22 . THR A 1 111 ? -2.86778  20.70419 16.04123  1.000 19.64171  ? 111 THR A HG22 1 
ATOM   1744 H HG23 . THR A 1 111 ? -1.29463  20.76607 15.92341  1.000 19.64171  ? 111 THR A HG23 1 
ATOM   1745 N N    . PHE A 1 112 ? -3.62128  24.93880 15.15818  1.000 14.08055  ? 112 PHE A N    1 
ATOM   1746 C CA   . PHE A 1 112 ? -4.02660  26.31793 15.26444  1.000 14.98975  ? 112 PHE A CA   1 
ATOM   1747 C C    . PHE A 1 112 ? -5.36876  26.37387 15.98979  1.000 15.76258  ? 112 PHE A C    1 
ATOM   1748 O O    . PHE A 1 112 ? -6.05649  25.37309 16.12939  1.000 15.58629  ? 112 PHE A O    1 
ATOM   1749 C CB   . PHE A 1 112 ? -4.13392  26.97695 13.87272  1.000 14.20702  ? 112 PHE A CB   1 
ATOM   1750 C CG   . PHE A 1 112 ? -5.06164  26.30063 12.91338  1.000 15.74821  ? 112 PHE A CG   1 
ATOM   1751 C CD1  . PHE A 1 112 ? -4.61684  25.24179 12.16237  1.000 18.23295  ? 112 PHE A CD1  1 
ATOM   1752 C CD2  . PHE A 1 112 ? -6.34566  26.69340 12.76167  1.000 13.41521  ? 112 PHE A CD2  1 
ATOM   1753 C CE1  . PHE A 1 112 ? -5.45528  24.61320 11.23949  1.000 19.64410  ? 112 PHE A CE1  1 
ATOM   1754 C CE2  . PHE A 1 112 ? -7.20790  26.12261 11.80678  1.000 17.15950  ? 112 PHE A CE2  1 
ATOM   1755 C CZ   . PHE A 1 112 ? -6.76557  25.05858 11.05778  1.000 18.00489  ? 112 PHE A CZ   1 
ATOM   1756 H H    . PHE A 1 112 ? -4.26624  24.37838 15.25598  1.000 16.89666  ? 112 PHE A H    1 
ATOM   1757 H HA   . PHE A 1 112 ? -3.37511  26.81029 15.78793  1.000 17.98770  ? 112 PHE A HA   1 
ATOM   1758 H HB2  . PHE A 1 112 ? -4.45058  27.88644 13.98878  1.000 17.04842  ? 112 PHE A HB2  1 
ATOM   1759 H HB3  . PHE A 1 112 ? -3.25242  26.98169 13.46796  1.000 17.04842  ? 112 PHE A HB3  1 
ATOM   1760 H HD1  . PHE A 1 112 ? -3.74428  24.93841 12.26961  1.000 21.87954  ? 112 PHE A HD1  1 
ATOM   1761 H HD2  . PHE A 1 112 ? -6.67315  27.36872 13.31085  1.000 16.09825  ? 112 PHE A HD2  1 
ATOM   1762 H HE1  . PHE A 1 112 ? -5.13875  23.89341 10.74289  1.000 23.57291  ? 112 PHE A HE1  1 
ATOM   1763 H HE2  . PHE A 1 112 ? -8.06547  26.46095 11.68432  1.000 20.59140  ? 112 PHE A HE2  1 
ATOM   1764 H HZ   . PHE A 1 112 ? -7.32719  24.64424 10.44311  1.000 21.60587  ? 112 PHE A HZ   1 
ATOM   1765 N N    . SER A 1 113 ? -5.72065  27.56385 16.43855  1.000 14.40636  ? 113 SER A N    1 
ATOM   1766 C CA   . SER A 1 113 ? -6.99084  27.79537 17.09012  1.000 12.63845  ? 113 SER A CA   1 
ATOM   1767 C C    . SER A 1 113 ? -7.97267  28.36629 16.08383  1.000 14.41253  ? 113 SER A C    1 
ATOM   1768 O O    . SER A 1 113 ? -7.59353  29.19269 15.24358  1.000 16.09843  ? 113 SER A O    1 
ATOM   1769 C CB   . SER A 1 113 ? -6.82928  28.85611 18.17298  1.000 16.11000  ? 113 SER A CB   1 
ATOM   1770 O OG   . SER A 1 113 ? -5.87639  28.42779 19.18441  1.000 16.01331  ? 113 SER A OG   1 
ATOM   1771 H H    . SER A 1 113 ? -5.22920  28.26675 16.37527  1.000 17.28764  ? 113 SER A H    1 
ATOM   1772 H HA   . SER A 1 113 ? -7.31903  26.96166 17.46177  1.000 15.16614  ? 113 SER A HA   1 
ATOM   1773 H HB2  . SER A 1 113 ? -6.50905  29.67608 17.76555  1.000 19.33199  ? 113 SER A HB2  1 
ATOM   1774 H HB3  . SER A 1 113 ? -7.68918  29.00913 18.59494  1.000 19.33199  ? 113 SER A HB3  1 
ATOM   1775 H HG   . SER A 1 113 ? -6.04832  27.64209 19.42670  1.000 19.21597  ? 113 SER A HG   1 
ATOM   1776 N N    . VAL A 1 114 ? -9.23981  27.96208 16.20083  1.000 15.27958  ? 114 VAL A N    1 
ATOM   1777 C CA   . VAL A 1 114 ? -10.32690 28.39606 15.33685  1.000 17.01819  ? 114 VAL A CA   1 
ATOM   1778 C C    . VAL A 1 114 ? -11.29022 29.20888 16.19050  1.000 13.46265  ? 114 VAL A C    1 
ATOM   1779 O O    . VAL A 1 114 ? -11.67909 28.76751 17.28257  1.000 16.32594  ? 114 VAL A O    1 
ATOM   1780 C CB   . VAL A 1 114 ? -11.06740 27.20163 14.71909  1.000 12.97865  ? 114 VAL A CB   1 
ATOM   1781 C CG1  . VAL A 1 114 ? -12.33653 27.65806 14.05736  1.000 16.98289  ? 114 VAL A CG1  1 
ATOM   1782 C CG2  . VAL A 1 114 ? -10.15633 26.47338 13.76064  1.000 16.55016  ? 114 VAL A CG2  1 
ATOM   1783 H H    . VAL A 1 114 ? -9.50155  27.40894 16.80509  1.000 18.33550  ? 114 VAL A H    1 
ATOM   1784 H HA   . VAL A 1 114 ? -9.97037  28.94747 14.62289  1.000 20.42182  ? 114 VAL A HA   1 
ATOM   1785 H HB   . VAL A 1 114 ? -11.32084 26.57435 15.41421  1.000 15.57438  ? 114 VAL A HB   1 
ATOM   1786 H HG11 . VAL A 1 114 ? -12.70187 26.92606 13.53620  1.000 20.37947  ? 114 VAL A HG11 1 
ATOM   1787 H HG12 . VAL A 1 114 ? -12.97040 27.92606 14.74095  1.000 20.37947  ? 114 VAL A HG12 1 
ATOM   1788 H HG13 . VAL A 1 114 ? -12.13769 28.40990 13.47762  1.000 20.37947  ? 114 VAL A HG13 1 
ATOM   1789 H HG21 . VAL A 1 114 ? -10.67145 25.80635 13.28040  1.000 19.86019  ? 114 VAL A HG21 1 
ATOM   1790 H HG22 . VAL A 1 114 ? -9.77902  27.11260 13.13619  1.000 19.86019  ? 114 VAL A HG22 1 
ATOM   1791 H HG23 . VAL A 1 114 ? -9.44677  26.04417 14.26383  1.000 19.86019  ? 114 VAL A HG23 1 
ATOM   1792 N N    . LEU A 1 115 ? -11.58961 30.41317 15.76388  1.000 14.95696  ? 115 LEU A N    1 
ATOM   1793 C CA   . LEU A 1 115 ? -12.66257 31.22578 16.33877  1.000 15.23918  ? 115 LEU A CA   1 
ATOM   1794 C C    . LEU A 1 115 ? -13.89565 31.08286 15.47405  1.000 16.51735  ? 115 LEU A C    1 
ATOM   1795 O O    . LEU A 1 115 ? -14.00350 31.73406 14.42488  1.000 16.36606  ? 115 LEU A O    1 
ATOM   1796 C CB   . LEU A 1 115 ? -12.26159 32.68919 16.49354  1.000 15.66342  ? 115 LEU A CB   1 
ATOM   1797 C CG   . LEU A 1 115 ? -13.28647 33.58364 17.15319  1.000 15.92920  ? 115 LEU A CG   1 
ATOM   1798 C CD1  . LEU A 1 115 ? -13.52834 33.16830 18.65804  1.000 18.02280  ? 115 LEU A CD1  1 
ATOM   1799 C CD2  . LEU A 1 115 ? -12.86178 35.05680 17.12076  1.000 18.99818  ? 115 LEU A CD2  1 
ATOM   1800 H H    . LEU A 1 115 ? -11.17675 30.80534 15.11941  1.000 17.94836  ? 115 LEU A H    1 
ATOM   1801 H HA   . LEU A 1 115 ? -12.85751 30.87625 17.22236  1.000 18.28701  ? 115 LEU A HA   1 
ATOM   1802 H HB2  . LEU A 1 115 ? -11.45575 32.72781 17.03208  1.000 18.79611  ? 115 LEU A HB2  1 
ATOM   1803 H HB3  . LEU A 1 115 ? -12.08822 33.05144 15.61058  1.000 18.79611  ? 115 LEU A HB3  1 
ATOM   1804 H HG   . LEU A 1 115 ? -14.11115 33.48160 16.65280  1.000 19.11504  ? 115 LEU A HG   1 
ATOM   1805 H HD11 . LEU A 1 115 ? -14.00017 32.32107 18.67988  1.000 21.62736  ? 115 LEU A HD11 1 
ATOM   1806 H HD12 . LEU A 1 115 ? -12.67098 33.08102 19.10326  1.000 21.62736  ? 115 LEU A HD12 1 
ATOM   1807 H HD13 . LEU A 1 115 ? -14.05891 33.85371 19.09346  1.000 21.62736  ? 115 LEU A HD13 1 
ATOM   1808 H HD21 . LEU A 1 115 ? -12.92132 35.38263 16.20906  1.000 22.79782  ? 115 LEU A HD21 1 
ATOM   1809 H HD22 . LEU A 1 115 ? -13.45335 35.56870 17.69427  1.000 22.79782  ? 115 LEU A HD22 1 
ATOM   1810 H HD23 . LEU A 1 115 ? -11.94831 35.12920 17.43892  1.000 22.79782  ? 115 LEU A HD23 1 
ATOM   1811 N N    . ALA A 1 116 ? -14.78736 30.16800 15.85563  1.000 15.96327  ? 116 ALA A N    1 
ATOM   1812 C CA   . ALA A 1 116 ? -16.03242 29.97713 15.12934  1.000 13.55191  ? 116 ALA A CA   1 
ATOM   1813 C C    . ALA A 1 116 ? -16.91418 31.19856 15.30886  1.000 17.82847  ? 116 ALA A C    1 
ATOM   1814 O O    . ALA A 1 116 ? -17.12732 31.64911 16.45367  1.000 18.57791  ? 116 ALA A O    1 
ATOM   1815 C CB   . ALA A 1 116 ? -16.71758 28.70120 15.57355  1.000 18.79444  ? 116 ALA A CB   1 
ATOM   1816 H H    . ALA A 1 116 ? -14.69152 29.64660 16.53279  1.000 19.15593  ? 116 ALA A H    1 
ATOM   1817 H HA   . ALA A 1 116 ? -15.85960 29.87692 14.18014  1.000 16.26229  ? 116 ALA A HA   1 
ATOM   1818 H HB1  . ALA A 1 116 ? -17.58798 28.64586 15.14900  1.000 22.55332  ? 116 ALA A HB1  1 
ATOM   1819 H HB2  . ALA A 1 116 ? -16.17290 27.94255 15.31150  1.000 22.55332  ? 116 ALA A HB2  1 
ATOM   1820 H HB3  . ALA A 1 116 ? -16.82037 28.71722 16.53795  1.000 22.55332  ? 116 ALA A HB3  1 
ATOM   1821 N N    . CYS A 1 117 ? -17.48356 31.69533 14.19733  1.000 14.92270  ? 117 CYS A N    1 
ATOM   1822 C CA   A CYS A 1 117 ? -18.24857 32.91814 14.20235  0.500 17.72391  ? 117 CYS A CA   1 
ATOM   1823 C CA   B CYS A 1 117 ? -18.23533 32.92311 14.19742  0.500 17.71356  ? 117 CYS A CA   1 
ATOM   1824 C C    . CYS A 1 117 ? -19.47541 32.75783 13.32298  1.000 19.14330  ? 117 CYS A C    1 
ATOM   1825 O O    . CYS A 1 117 ? -19.45352 32.06370 12.31366  1.000 18.06925  ? 117 CYS A O    1 
ATOM   1826 C CB   A CYS A 1 117 ? -17.45997 34.09826 13.63628  0.500 20.60443  ? 117 CYS A CB   1 
ATOM   1827 C CB   B CYS A 1 117 ? -17.32007 34.02452 13.63555  0.500 21.10745  ? 117 CYS A CB   1 
ATOM   1828 S SG   A CYS A 1 117 ? -16.09879 34.60473 14.62783  0.500 15.34608  ? 117 CYS A SG   1 
ATOM   1829 S SG   B CYS A 1 117 ? -17.77934 35.71895 13.87357  0.500 28.40074  ? 117 CYS A SG   1 
ATOM   1830 H H    . CYS A 1 117 ? -17.43003 31.32322 13.42385  1.000 17.90725  ? 117 CYS A H    1 
ATOM   1831 H HA   . CYS A 1 117 ? -18.50808 33.09860 15.11940  1.000 21.25627  ? 117 CYS A HA   1 
ATOM   1832 H HB2  A CYS A 1 117 ? -17.11224 33.84875 12.76580  0.500 24.72532  ? 117 CYS A HB2  1 
ATOM   1833 H HB2  B CYS A 1 117 ? -16.44759 33.91644 14.04543  0.500 25.32894  ? 117 CYS A HB2  1 
ATOM   1834 H HB3  A CYS A 1 117 ? -18.05824 34.85684 13.54954  0.500 24.72532  ? 117 CYS A HB3  1 
ATOM   1835 H HB3  B CYS A 1 117 ? -17.25537 33.88969 12.67715  0.500 25.32894  ? 117 CYS A HB3  1 
ATOM   1836 H HG   A CYS A 1 117 ? -15.30628 33.70593 14.69186  0.500 18.41530  ? 117 CYS A HG   1 
ATOM   1837 H HG   B CYS A 1 117 ? -17.49153 36.04848 14.99096  0.500 34.08089  ? 117 CYS A HG   1 
ATOM   1838 N N    . TYR A 1 118 ? -20.54526 33.44045 13.70551  1.000 17.61926  ? 118 TYR A N    1 
ATOM   1839 C CA   . TYR A 1 118 ? -21.79212 33.49755 12.95751  1.000 18.86560  ? 118 TYR A CA   1 
ATOM   1840 C C    . TYR A 1 118 ? -22.30044 34.93740 13.00481  1.000 18.55441  ? 118 TYR A C    1 
ATOM   1841 O O    . TYR A 1 118 ? -22.25922 35.59008 14.04978  1.000 19.65633  ? 118 TYR A O    1 
ATOM   1842 C CB   . TYR A 1 118 ? -22.84809 32.55368 13.53473  1.000 20.74646  ? 118 TYR A CB   1 
ATOM   1843 C CG   . TYR A 1 118 ? -22.36900 31.12596 13.48628  1.000 15.78088  ? 118 TYR A CG   1 
ATOM   1844 C CD1  . TYR A 1 118 ? -21.59346 30.60920 14.53622  1.000 15.48802  ? 118 TYR A CD1  1 
ATOM   1845 C CD2  . TYR A 1 118 ? -22.56698 30.33755 12.37521  1.000 20.73692  ? 118 TYR A CD2  1 
ATOM   1846 C CE1  . TYR A 1 118 ? -21.10659 29.32954 14.48012  1.000 18.01518  ? 118 TYR A CE1  1 
ATOM   1847 C CE2  . TYR A 1 118 ? -22.09873 29.05476 12.31208  1.000 18.91822  ? 118 TYR A CE2  1 
ATOM   1848 C CZ   . TYR A 1 118 ? -21.32992 28.56033 13.36575  1.000 21.90075  ? 118 TYR A CZ   1 
ATOM   1849 O OH   . TYR A 1 118 ? -20.82221 27.27273 13.25601  1.000 20.01447  ? 118 TYR A OH   1 
ATOM   1850 H H    . TYR A 1 118 ? -20.57530 33.90160 14.43079  1.000 21.14312  ? 118 TYR A H    1 
ATOM   1851 H HA   . TYR A 1 118 ? -21.64167 33.23692 12.03538  1.000 22.63872  ? 118 TYR A HA   1 
ATOM   1852 H HB2  . TYR A 1 118 ? -23.02272 32.78989 14.45918  1.000 24.89576  ? 118 TYR A HB2  1 
ATOM   1853 H HB3  . TYR A 1 118 ? -23.66386 32.62376 13.01462  1.000 24.89576  ? 118 TYR A HB3  1 
ATOM   1854 H HD1  . TYR A 1 118 ? -21.40839 31.14038 15.27683  1.000 18.58563  ? 118 TYR A HD1  1 
ATOM   1855 H HD2  . TYR A 1 118 ? -23.03124 30.68662 11.64891  1.000 24.88430  ? 118 TYR A HD2  1 
ATOM   1856 H HE1  . TYR A 1 118 ? -20.62537 28.98271 15.19639  1.000 21.61821  ? 118 TYR A HE1  1 
ATOM   1857 H HE2  . TYR A 1 118 ? -22.29018 28.51890 11.57649  1.000 22.70187  ? 118 TYR A HE2  1 
ATOM   1858 H HH   . TYR A 1 118 ? -20.08262 27.22091 13.65088  1.000 24.01736  ? 118 TYR A HH   1 
ATOM   1859 N N    . ASN A 1 119 ? -22.74495 35.43508 11.85195  1.000 22.59474  ? 119 ASN A N    1 
ATOM   1860 C CA   . ASN A 1 119 ? -23.26742 36.80553 11.76340  1.000 23.69786  ? 119 ASN A CA   1 
ATOM   1861 C C    . ASN A 1 119 ? -22.27805 37.84463 12.26858  1.000 22.30656  ? 119 ASN A C    1 
ATOM   1862 O O    . ASN A 1 119 ? -22.65235 38.85448 12.86591  1.000 24.71536  ? 119 ASN A O    1 
ATOM   1863 C CB   . ASN A 1 119 ? -24.60955 36.90647 12.49553  1.000 27.44805  ? 119 ASN A CB   1 
ATOM   1864 C CG   . ASN A 1 119 ? -25.58579 35.83374 12.04765  1.000 26.87362  ? 119 ASN A CG   1 
ATOM   1865 O OD1  . ASN A 1 119 ? -25.95885 34.95769 12.84638  1.000 35.68654  ? 119 ASN A OD1  1 
ATOM   1866 N ND2  . ASN A 1 119 ? -25.98765 35.87634 10.81103  1.000 34.84306  ? 119 ASN A ND2  1 
ATOM   1867 H H    . ASN A 1 119 ? -22.75579 35.00343 11.10820  1.000 27.11369  ? 119 ASN A H    1 
ATOM   1868 H HA   . ASN A 1 119 ? -23.40783 37.01623 10.82703  1.000 28.43743  ? 119 ASN A HA   1 
ATOM   1869 H HB2  . ASN A 1 119 ? -24.46140 36.80231 13.44847  1.000 32.93766  ? 119 ASN A HB2  1 
ATOM   1870 H HB3  . ASN A 1 119 ? -25.00712 37.77249 12.31430  1.000 32.93766  ? 119 ASN A HB3  1 
ATOM   1871 H HD21 . ASN A 1 119 ? -26.54078 35.28656 10.51808  1.000 41.81168  ? 119 ASN A HD21 1 
ATOM   1872 H HD22 . ASN A 1 119 ? -25.70017 36.49427 10.28651  1.000 41.81168  ? 119 ASN A HD22 1 
ATOM   1873 N N    . GLY A 1 120 ? -20.97584 37.62274 12.01479  1.000 17.65337  ? 120 GLY A N    1 
ATOM   1874 C CA   . GLY A 1 120 ? -19.93810 38.45658 12.54730  1.000 20.49180  ? 120 GLY A CA   1 
ATOM   1875 C C    . GLY A 1 120 ? -19.71918 38.38861 14.04371  1.000 21.65394  ? 120 GLY A C    1 
ATOM   1876 O O    . GLY A 1 120 ? -18.88945 39.15041 14.57512  1.000 25.17441  ? 120 GLY A O    1 
ATOM   1877 H H    . GLY A 1 120 ? -20.68266 36.97885 11.52585  1.000 21.18405  ? 120 GLY A H    1 
ATOM   1878 H HA2  . GLY A 1 120 ? -19.10189 38.21078 12.12158  1.000 24.59016  ? 120 GLY A HA2  1 
ATOM   1879 H HA3  . GLY A 1 120 ? -20.14552 39.37825 12.32728  1.000 24.59016  ? 120 GLY A HA3  1 
ATOM   1880 N N    . SER A 1 121 ? -20.38685 37.46084 14.74493  1.000 20.82756  ? 121 SER A N    1 
ATOM   1881 C CA   . SER A 1 121 ? -20.28889 37.39632 16.20538  1.000 22.77125  ? 121 SER A CA   1 
ATOM   1882 C C    . SER A 1 121 ? -19.58748 36.10642 16.63669  1.000 19.41770  ? 121 SER A C    1 
ATOM   1883 O O    . SER A 1 121 ? -20.06157 35.00469 16.30549  1.000 21.57441  ? 121 SER A O    1 
ATOM   1884 C CB   . SER A 1 121 ? -21.70466 37.40823 16.78876  1.000 22.31473  ? 121 SER A CB   1 
ATOM   1885 O OG   . SER A 1 121 ? -22.21378 38.71965 16.77490  1.000 38.79999  ? 121 SER A OG   1 
ATOM   1886 H H    . SER A 1 121 ? -20.89850 36.86345 14.39717  1.000 24.99308  ? 121 SER A H    1 
ATOM   1887 H HA   . SER A 1 121 ? -19.77063 38.14934 16.52985  1.000 27.32550  ? 121 SER A HA   1 
ATOM   1888 H HB2  . SER A 1 121 ? -22.27663 36.83714 16.25247  1.000 26.77768  ? 121 SER A HB2  1 
ATOM   1889 H HB3  . SER A 1 121 ? -21.67684 37.08532 17.70301  1.000 26.77768  ? 121 SER A HB3  1 
ATOM   1890 H HG   . SER A 1 121 ? -21.69054 39.23529 17.18226  1.000 46.55999  ? 121 SER A HG   1 
ATOM   1891 N N    . PRO A 1 122 ? -18.45442 36.20389 17.33345  1.000 21.63128  ? 122 PRO A N    1 
ATOM   1892 C CA   . PRO A 1 122 ? -17.77784 34.98810 17.80323  1.000 19.94420  ? 122 PRO A CA   1 
ATOM   1893 C C    . PRO A 1 122 ? -18.64943 34.13115 18.70174  1.000 21.39628  ? 122 PRO A C    1 
ATOM   1894 O O    . PRO A 1 122 ? -19.31261 34.63738 19.60999  1.000 23.58723  ? 122 PRO A O    1 
ATOM   1895 C CB   . PRO A 1 122 ? -16.56233 35.53863 18.54279  1.000 25.68612  ? 122 PRO A CB   1 
ATOM   1896 C CG   . PRO A 1 122 ? -16.26813 36.82839 17.83552  1.000 29.19807  ? 122 PRO A CG   1 
ATOM   1897 C CD   . PRO A 1 122 ? -17.61401 37.40431 17.49874  1.000 24.91462  ? 122 PRO A CD   1 
ATOM   1898 H HA   . PRO A 1 122 ? -17.49911 34.44887 17.04663  1.000 23.93303  ? 122 PRO A HA   1 
ATOM   1899 H HB2  . PRO A 1 122 ? -16.77847 35.69077 19.47608  1.000 30.82335  ? 122 PRO A HB2  1 
ATOM   1900 H HB3  . PRO A 1 122 ? -15.81816 34.92060 18.47107  1.000 30.82335  ? 122 PRO A HB3  1 
ATOM   1901 H HG2  . PRO A 1 122 ? -15.77430 37.42199 18.42260  1.000 35.03769  ? 122 PRO A HG2  1 
ATOM   1902 H HG3  . PRO A 1 122 ? -15.75456 36.65449 17.03121  1.000 35.03769  ? 122 PRO A HG3  1 
ATOM   1903 H HD2  . PRO A 1 122 ? -17.94341 37.96125 18.22139  1.000 29.89755  ? 122 PRO A HD2  1 
ATOM   1904 H HD3  . PRO A 1 122 ? -17.57578 37.91667 16.67598  1.000 29.89755  ? 122 PRO A HD3  1 
ATOM   1905 N N    . SER A 1 123 ? -18.61462 32.82776 18.46444  1.000 21.22905  ? 123 SER A N    1 
ATOM   1906 C CA   . SER A 1 123 ? -19.40778 31.82366 19.15569  1.000 20.96375  ? 123 SER A CA   1 
ATOM   1907 C C    . SER A 1 123 ? -18.58517 30.87853 20.01960  1.000 22.59928  ? 123 SER A C    1 
ATOM   1908 O O    . SER A 1 123 ? -19.05883 30.45798 21.10014  1.000 20.92328  ? 123 SER A O    1 
ATOM   1909 C CB   . SER A 1 123 ? -20.13104 30.97131 18.10182  1.000 29.80890  ? 123 SER A CB   1 
ATOM   1910 O OG   . SER A 1 123 ? -20.62762 29.77047 18.64959  1.000 47.86741  ? 123 SER A OG   1 
ATOM   1911 H H    . SER A 1 123 ? -18.10473 32.47732 17.86710  1.000 25.47486  ? 123 SER A H    1 
ATOM   1912 H HA   . SER A 1 123 ? -20.04977 32.26992 19.72980  1.000 25.15650  ? 123 SER A HA   1 
ATOM   1913 H HB2  . SER A 1 123 ? -20.87436 31.48186 17.74445  1.000 35.77068  ? 123 SER A HB2  1 
ATOM   1914 H HB3  . SER A 1 123 ? -19.50550 30.75532 17.39263  1.000 35.77068  ? 123 SER A HB3  1 
ATOM   1915 H HG   . SER A 1 123 ? -21.03589 29.33300 18.06007  1.000 57.44089  ? 123 SER A HG   1 
ATOM   1916 N N    . GLY A 1 124 ? -17.36230 30.53516 19.63799  1.000 17.90709  ? 124 GLY A N    1 
ATOM   1917 C CA   . GLY A 1 124 ? -16.56507 29.59890 20.42797  1.000 19.78543  ? 124 GLY A CA   1 
ATOM   1918 C C    . GLY A 1 124 ? -15.17805 29.48109 19.84289  1.000 18.28390  ? 124 GLY A C    1 
ATOM   1919 O O    . GLY A 1 124 ? -14.93150 29.89271 18.69141  1.000 16.86414  ? 124 GLY A O    1 
ATOM   1920 H H    . GLY A 1 124 ? -16.97046 30.82673 18.93014  1.000 21.48851  ? 124 GLY A H    1 
ATOM   1921 H HA2  . GLY A 1 124 ? -16.49570 29.91338 21.34295  1.000 23.74252  ? 124 GLY A HA2  1 
ATOM   1922 H HA3  . GLY A 1 124 ? -16.98367 28.72388 20.42565  1.000 23.74252  ? 124 GLY A HA3  1 
ATOM   1923 N N    . VAL A 1 125 ? -14.27961 28.91359 20.61983  1.000 14.24745  ? 125 VAL A N    1 
ATOM   1924 C CA   . VAL A 1 125 ? -12.87366 28.79010 20.27127  1.000 16.66675  ? 125 VAL A CA   1 
ATOM   1925 C C    . VAL A 1 125 ? -12.40772 27.37223 20.56170  1.000 17.51417  ? 125 VAL A C    1 
ATOM   1926 O O    . VAL A 1 125 ? -12.71466 26.81945 21.62766  1.000 18.95789  ? 125 VAL A O    1 
ATOM   1927 C CB   . VAL A 1 125 ? -11.99201 29.86841 20.90512  1.000 19.65452  ? 125 VAL A CB   1 
ATOM   1928 C CG1  . VAL A 1 125 ? -11.86412 29.63157 22.37327  1.000 24.07974  ? 125 VAL A CG1  1 
ATOM   1929 C CG2  . VAL A 1 125 ? -10.60846 29.94455 20.26588  1.000 21.03315  ? 125 VAL A CG2  1 
ATOM   1930 H H    . VAL A 1 125 ? -14.46464 28.57633 21.38899  1.000 17.09695  ? 125 VAL A H    1 
ATOM   1931 H HA   . VAL A 1 125 ? -12.77814 28.91692 19.31435  1.000 20.00010  ? 125 VAL A HA   1 
ATOM   1932 H HB   . VAL A 1 125 ? -12.42292 30.72363 20.75076  1.000 23.58542  ? 125 VAL A HB   1 
ATOM   1933 H HG11 . VAL A 1 125 ? -12.57734 29.04051 22.66111  1.000 28.89568  ? 125 VAL A HG11 1 
ATOM   1934 H HG12 . VAL A 1 125 ? -11.00299 29.22304 22.55342  1.000 28.89568  ? 125 VAL A HG12 1 
ATOM   1935 H HG13 . VAL A 1 125 ? -11.93085 30.48084 22.83715  1.000 28.89568  ? 125 VAL A HG13 1 
ATOM   1936 H HG21 . VAL A 1 125 ? -10.27893 29.04430 20.11802  1.000 25.23978  ? 125 VAL A HG21 1 
ATOM   1937 H HG22 . VAL A 1 125 ? -10.67672 30.41486 19.42028  1.000 25.23978  ? 125 VAL A HG22 1 
ATOM   1938 H HG23 . VAL A 1 125 ? -10.01076 30.42175 20.86249  1.000 25.23978  ? 125 VAL A HG23 1 
ATOM   1939 N N    . TYR A 1 126 ? -11.65610 26.77479 19.63921  1.000 15.80588  ? 126 TYR A N    1 
ATOM   1940 C CA   . TYR A 1 126 ? -11.17354 25.40532 19.80175  1.000 15.58712  ? 126 TYR A CA   1 
ATOM   1941 C C    . TYR A 1 126 ? -9.90434  25.21427 18.98994  1.000 18.56818  ? 126 TYR A C    1 
ATOM   1942 O O    . TYR A 1 126 ? -9.62900  25.98109 18.06702  1.000 18.57998  ? 126 TYR A O    1 
ATOM   1943 C CB   . TYR A 1 126 ? -12.22820 24.38262 19.46731  1.000 16.66598  ? 126 TYR A CB   1 
ATOM   1944 C CG   . TYR A 1 126 ? -12.79578 24.46156 18.08206  1.000 16.24142  ? 126 TYR A CG   1 
ATOM   1945 C CD1  . TYR A 1 126 ? -12.20545 23.79156 17.03164  1.000 23.01375  ? 126 TYR A CD1  1 
ATOM   1946 C CD2  . TYR A 1 126 ? -13.90968 25.23056 17.81570  1.000 20.03595  ? 126 TYR A CD2  1 
ATOM   1947 C CE1  . TYR A 1 126 ? -12.73298 23.86293 15.75676  1.000 23.87868  ? 126 TYR A CE1  1 
ATOM   1948 C CE2  . TYR A 1 126 ? -14.45295 25.30548 16.52619  1.000 20.58842  ? 126 TYR A CE2  1 
ATOM   1949 C CZ   . TYR A 1 126 ? -13.85025 24.62173 15.51479  1.000 19.22033  ? 126 TYR A CZ   1 
ATOM   1950 O OH   . TYR A 1 126 ? -14.37847 24.68273 14.22445  1.000 23.75610  ? 126 TYR A OH   1 
ATOM   1951 H H    . TYR A 1 126 ? -11.40941 27.14474 18.90308  1.000 18.96705  ? 126 TYR A H    1 
ATOM   1952 H HA   . TYR A 1 126 ? -10.93385 25.26600 20.73129  1.000 18.70454  ? 126 TYR A HA   1 
ATOM   1953 H HB2  . TYR A 1 126 ? -11.83889 23.49998 19.56868  1.000 19.99917  ? 126 TYR A HB2  1 
ATOM   1954 H HB3  . TYR A 1 126 ? -12.96614 24.49291 20.08713  1.000 19.99917  ? 126 TYR A HB3  1 
ATOM   1955 H HD1  . TYR A 1 126 ? -11.44100 23.28416 17.18348  1.000 27.61650  ? 126 TYR A HD1  1 
ATOM   1956 H HD2  . TYR A 1 126 ? -14.30832 25.70919 18.50628  1.000 24.04314  ? 126 TYR A HD2  1 
ATOM   1957 H HE1  . TYR A 1 126 ? -12.32989 23.39562 15.06103  1.000 28.65442  ? 126 TYR A HE1  1 
ATOM   1958 H HE2  . TYR A 1 126 ? -15.21396 25.81474 16.36363  1.000 24.70610  ? 126 TYR A HE2  1 
ATOM   1959 H HH   . TYR A 1 126 ? -15.04801 25.18983 14.21178  1.000 28.50732  ? 126 TYR A HH   1 
ATOM   1960 N N    . GLN A 1 127 ? -9.15724  24.16074 19.33107  1.000 15.09106  ? 127 GLN A N    1 
ATOM   1961 C CA   A GLN A 1 127 ? -7.93232  23.80817 18.62358  0.500 17.88155  ? 127 GLN A CA   1 
ATOM   1962 C CA   B GLN A 1 127 ? -7.93204  23.80203 18.61820  0.500 17.88320  ? 127 GLN A CA   1 
ATOM   1963 C C    . GLN A 1 127 ? -8.21623  22.80799 17.50064  1.000 19.18172  ? 127 GLN A C    1 
ATOM   1964 O O    . GLN A 1 127 ? -9.00176  21.87398 17.66408  1.000 24.37944  ? 127 GLN A O    1 
ATOM   1965 C CB   A GLN A 1 127 ? -6.97841  23.18297 19.65906  0.500 22.38884  ? 127 GLN A CB   1 
ATOM   1966 C CB   B GLN A 1 127 ? -6.96082  23.12649 19.60111  0.500 22.46605  ? 127 GLN A CB   1 
ATOM   1967 C CG   A GLN A 1 127 ? -5.53040  23.32689 19.36132  0.500 19.13546  ? 127 GLN A CG   1 
ATOM   1968 C CG   B GLN A 1 127 ? -6.16197  24.04458 20.40803  0.500 13.16731  ? 127 GLN A CG   1 
ATOM   1969 C CD   A GLN A 1 127 ? -5.05963  24.77477 19.38075  0.500 17.60340  ? 127 GLN A CD   1 
ATOM   1970 C CD   B GLN A 1 127 ? -5.13894  24.82926 19.60714  0.500 17.24987  ? 127 GLN A CD   1 
ATOM   1971 O OE1  A GLN A 1 127 ? -5.86736  25.72145 19.51774  0.500 16.45776  ? 127 GLN A OE1  1 
ATOM   1972 O OE1  B GLN A 1 127 ? -5.36301  25.99899 19.26155  0.500 19.73539  ? 127 GLN A OE1  1 
ATOM   1973 N NE2  A GLN A 1 127 ? -3.75629  24.96206 19.23939  0.500 20.94920  ? 127 GLN A NE2  1 
ATOM   1974 N NE2  B GLN A 1 127 ? -4.00854  24.19269 19.30495  0.500 17.66274  ? 127 GLN A NE2  1 
ATOM   1975 H H    . GLN A 1 127 ? -9.34375  23.63117 19.98251  1.000 18.10927  ? 127 GLN A H    1 
ATOM   1976 H HA   . GLN A 1 127 ? -7.52940  24.58600 18.20701  1.000 21.45984  ? 127 GLN A HA   1 
ATOM   1977 H HB2  A GLN A 1 127 ? -7.14029  23.60520 20.51721  0.500 26.86661  ? 127 GLN A HB2  1 
ATOM   1978 H HB2  B GLN A 1 127 ? -7.47548  22.57538 20.21128  0.500 26.95926  ? 127 GLN A HB2  1 
ATOM   1979 H HB3  A GLN A 1 127 ? -7.16883  22.23350 19.71530  0.500 26.86661  ? 127 GLN A HB3  1 
ATOM   1980 H HB3  B GLN A 1 127 ? -6.34548  22.57421 19.09391  0.500 26.95926  ? 127 GLN A HB3  1 
ATOM   1981 H HG2  A GLN A 1 127 ? -5.02171  22.83830 20.02722  0.500 22.96255  ? 127 GLN A HG2  1 
ATOM   1982 H HG2  B GLN A 1 127 ? -6.75521  24.68199 20.83544  0.500 15.80078  ? 127 GLN A HG2  1 
ATOM   1983 H HG3  A GLN A 1 127 ? -5.35297  22.96679 18.47829  0.500 22.96255  ? 127 GLN A HG3  1 
ATOM   1984 H HG3  B GLN A 1 127 ? -5.68347  23.53441 21.08009  0.500 15.80078  ? 127 GLN A HG3  1 
ATOM   1985 H HE21 A GLN A 1 127 ? -3.23263  24.28654 19.14425  0.500 25.13904  ? 127 GLN A HE21 1 
ATOM   1986 H HE21 B GLN A 1 127 ? -3.39693  24.59375 18.85253  0.500 21.19529  ? 127 GLN A HE21 1 
ATOM   1987 H HE22 A GLN A 1 127 ? -3.43357  25.75920 19.24272  0.500 25.13904  ? 127 GLN A HE22 1 
ATOM   1988 H HE22 B GLN A 1 127 ? -3.89033  23.38065 19.56228  0.500 21.19529  ? 127 GLN A HE22 1 
ATOM   1989 N N    . CYS A 1 128 ? -7.52345  22.98570 16.36053  1.000 19.93652  ? 128 CYS A N    1 
ATOM   1990 C CA   . CYS A 1 128 ? -7.56331  22.09156 15.22343  1.000 22.38931  ? 128 CYS A CA   1 
ATOM   1991 C C    . CYS A 1 128 ? -6.13823  21.77061 14.78769  1.000 19.25947  ? 128 CYS A C    1 
ATOM   1992 O O    . CYS A 1 128 ? -5.22817  22.54614 15.02664  1.000 23.24295  ? 128 CYS A O    1 
ATOM   1993 C CB   . CYS A 1 128 ? -8.26096  22.76103 13.96900  1.000 18.01953  ? 128 CYS A CB   1 
ATOM   1994 S SG   . CYS A 1 128 ? -10.01952 22.70073 14.12175  1.000 31.71192  ? 128 CYS A SG   1 
ATOM   1995 H H    . CYS A 1 128 ? -7.00066  23.65588 16.22957  1.000 23.92382  ? 128 CYS A H    1 
ATOM   1996 H HA   . CYS A 1 128 ? -8.04014  21.28863 15.48579  1.000 26.86717  ? 128 CYS A HA   1 
ATOM   1997 H HB2  . CYS A 1 128 ? -7.98842  23.68978 13.90533  1.000 21.62344  ? 128 CYS A HB2  1 
ATOM   1998 H HB3  . CYS A 1 128 ? -8.00461  22.28414 13.16416  1.000 21.62344  ? 128 CYS A HB3  1 
ATOM   1999 H HG   . CYS A 1 128 ? -10.36568 21.55451 14.20138  1.000 38.05431  ? 128 CYS A HG   1 
ATOM   2000 N N    . ALA A 1 129 ? -5.95346  20.60039 14.13720  1.000 20.20482  ? 129 ALA A N    1 
ATOM   2001 C CA   . ALA A 1 129 ? -4.72059  20.30602 13.42663  1.000 17.08249  ? 129 ALA A CA   1 
ATOM   2002 C C    . ALA A 1 129 ? -5.04746  20.24724 11.94477  1.000 17.53335  ? 129 ALA A C    1 
ATOM   2003 O O    . ALA A 1 129 ? -6.11753  19.78916 11.57330  1.000 18.66595  ? 129 ALA A O    1 
ATOM   2004 C CB   . ALA A 1 129 ? -4.15104  18.96381 13.83649  1.000 18.89963  ? 129 ALA A CB   1 
ATOM   2005 H H    . ALA A 1 129 ? -6.53766  19.97025 14.10212  1.000 24.24579  ? 129 ALA A H    1 
ATOM   2006 H HA   . ALA A 1 129 ? -4.05806  20.98961 13.61282  1.000 20.49898  ? 129 ALA A HA   1 
ATOM   2007 H HB1  . ALA A 1 129 ? -3.97297  18.97416 14.78995  1.000 22.67956  ? 129 ALA A HB1  1 
ATOM   2008 H HB2  . ALA A 1 129 ? -4.79612  18.27005 13.62798  1.000 22.67956  ? 129 ALA A HB2  1 
ATOM   2009 H HB3  . ALA A 1 129 ? -3.32775  18.80761 13.34791  1.000 22.67956  ? 129 ALA A HB3  1 
ATOM   2010 N N    . MET A 1 130 ? -4.10700  20.67690 11.10932  1.000 15.26779  ? 130 MET A N    1 
ATOM   2011 C CA   . MET A 1 130 ? -4.19789  20.47129 9.66518   1.000 15.26222  ? 130 MET A CA   1 
ATOM   2012 C C    . MET A 1 130 ? -3.83640  19.00828 9.40691   1.000 17.76056  ? 130 MET A C    1 
ATOM   2013 O O    . MET A 1 130 ? -2.71116  18.56281 9.71774   1.000 15.72047  ? 130 MET A O    1 
ATOM   2014 C CB   . MET A 1 130 ? -3.26919  21.42252 8.93095   1.000 15.93790  ? 130 MET A CB   1 
ATOM   2015 C CG   . MET A 1 130 ? -3.24407  21.27647 7.39156   1.000 21.41069  ? 130 MET A CG   1 
ATOM   2016 S SD   . MET A 1 130 ? -4.80057  21.72140 6.60477   1.000 21.05212  ? 130 MET A SD   1 
ATOM   2017 C CE   . MET A 1 130 ? -5.09849  23.39702 7.08958   1.000 17.96433  ? 130 MET A CE   1 
ATOM   2018 H H    . MET A 1 130 ? -3.39729  21.09550 11.35565  1.000 18.32135  ? 130 MET A H    1 
ATOM   2019 H HA   . MET A 1 130 ? -5.09095  20.66141 9.33777   1.000 18.31466  ? 130 MET A HA   1 
ATOM   2020 H HB2  . MET A 1 130 ? -3.54443  22.33113 9.12984   1.000 19.12548  ? 130 MET A HB2  1 
ATOM   2021 H HB3  . MET A 1 130 ? -2.36538  21.27239 9.24953   1.000 19.12548  ? 130 MET A HB3  1 
ATOM   2022 H HG2  . MET A 1 130 ? -2.55366  21.85581 7.03296   1.000 25.69283  ? 130 MET A HG2  1 
ATOM   2023 H HG3  . MET A 1 130 ? -3.05134  20.35260 7.16746   1.000 25.69283  ? 130 MET A HG3  1 
ATOM   2024 H HE1  . MET A 1 130 ? -5.90313  23.71447 6.65063   1.000 21.55720  ? 130 MET A HE1  1 
ATOM   2025 H HE2  . MET A 1 130 ? -5.21118  23.43193 8.05237   1.000 21.55720  ? 130 MET A HE2  1 
ATOM   2026 H HE3  . MET A 1 130 ? -4.34065  23.94175 6.82528   1.000 21.55720  ? 130 MET A HE3  1 
ATOM   2027 N N    . ARG A 1 131 ? -4.78052  18.25961 8.89033   1.000 15.50458  ? 131 ARG A N    1 
ATOM   2028 C CA   . ARG A 1 131 ? -4.53317  16.80705 8.63034   1.000 16.44582  ? 131 ARG A CA   1 
ATOM   2029 C C    . ARG A 1 131 ? -3.56140  16.64154 7.46968   1.000 15.41971  ? 131 ARG A C    1 
ATOM   2030 O O    . ARG A 1 131 ? -3.41655  17.53129 6.62732   1.000 15.57382  ? 131 ARG A O    1 
ATOM   2031 C CB   . ARG A 1 131 ? -5.82744  16.08682 8.28481   1.000 17.67630  ? 131 ARG A CB   1 
ATOM   2032 C CG   . ARG A 1 131 ? -6.91873  16.11334 9.32524   1.000 17.87648  ? 131 ARG A CG   1 
ATOM   2033 C CD   . ARG A 1 131 ? -6.42469  15.70296 10.70749  1.000 18.21241  ? 131 ARG A CD   1 
ATOM   2034 N NE   . ARG A 1 131 ? -5.79483  14.40358 10.64937  1.000 18.43222  ? 131 ARG A NE   1 
ATOM   2035 C CZ   . ARG A 1 131 ? -5.14079  13.86801 11.68202  1.000 20.63986  ? 131 ARG A CZ   1 
ATOM   2036 N NH1  . ARG A 1 131 ? -5.09689  14.47958 12.86742  1.000 20.76665  ? 131 ARG A NH1  1 
ATOM   2037 N NH2  . ARG A 1 131 ? -4.53748  12.69429 11.52462  1.000 20.25163  ? 131 ARG A NH2  1 
ATOM   2038 H H    . ARG A 1 131 ? -5.56626  18.53579 8.67604   1.000 18.60550  ? 131 ARG A H    1 
ATOM   2039 H HA   . ARG A 1 131 ? -4.15921  16.40573 9.43033   1.000 19.73499  ? 131 ARG A HA   1 
ATOM   2040 H HB2  . ARG A 1 131 ? -6.19142  16.49245 7.48238   1.000 21.21156  ? 131 ARG A HB2  1 
ATOM   2041 H HB3  . ARG A 1 131 ? -5.61690  15.15456 8.11909   1.000 21.21156  ? 131 ARG A HB3  1 
ATOM   2042 H HG2  . ARG A 1 131 ? -7.27355  17.01386 9.38902   1.000 21.45178  ? 131 ARG A HG2  1 
ATOM   2043 H HG3  . ARG A 1 131 ? -7.62110  15.49781 9.06313   1.000 21.45178  ? 131 ARG A HG3  1 
ATOM   2044 H HD2  . ARG A 1 131 ? -5.77471  16.34869 11.02600  1.000 21.85489  ? 131 ARG A HD2  1 
ATOM   2045 H HD3  . ARG A 1 131 ? -7.17464  15.65689 11.32097  1.000 21.85489  ? 131 ARG A HD3  1 
ATOM   2046 H HE   . ARG A 1 131 ? -5.84364  13.95563 9.91687   1.000 22.11866  ? 131 ARG A HE   1 
ATOM   2047 H HH11 . ARG A 1 131 ? -5.49503  15.23394 12.97710  1.000 24.91998  ? 131 ARG A HH11 1 
ATOM   2048 H HH12 . ARG A 1 131 ? -4.67046  14.11932 13.52162  1.000 24.91998  ? 131 ARG A HH12 1 
ATOM   2049 H HH21 . ARG A 1 131 ? -4.57210  12.29137 10.76563  1.000 24.30195  ? 131 ARG A HH21 1 
ATOM   2050 H HH22 . ARG A 1 131 ? -4.11246  12.33772 12.18175  1.000 24.30195  ? 131 ARG A HH22 1 
ATOM   2051 N N    . PRO A 1 132 ? -2.88226  15.48380 7.39420   1.000 15.43322  ? 132 PRO A N    1 
ATOM   2052 C CA   . PRO A 1 132 ? -2.06291  15.17856 6.21380   1.000 17.24175  ? 132 PRO A CA   1 
ATOM   2053 C C    . PRO A 1 132 ? -2.79298  15.33205 4.89208   1.000 17.62043  ? 132 PRO A C    1 
ATOM   2054 O O    . PRO A 1 132 ? -2.15640  15.63217 3.86112   1.000 17.55045  ? 132 PRO A O    1 
ATOM   2055 C CB   . PRO A 1 132 ? -1.64355  13.71298 6.44121   1.000 17.99698  ? 132 PRO A CB   1 
ATOM   2056 C CG   . PRO A 1 132 ? -1.56226  13.60899 7.95517   1.000 18.57135  ? 132 PRO A CG   1 
ATOM   2057 C CD   . PRO A 1 132 ? -2.74034  14.43854 8.45086   1.000 19.94160  ? 132 PRO A CD   1 
ATOM   2058 H HA   . PRO A 1 132 ? -1.27978  15.75092 6.21753   1.000 20.69010  ? 132 PRO A HA   1 
ATOM   2059 H HB2  . PRO A 1 132 ? -2.31249  13.11031 6.08037   1.000 21.59638  ? 132 PRO A HB2  1 
ATOM   2060 H HB3  . PRO A 1 132 ? -0.78335  13.53970 6.02776   1.000 21.59638  ? 132 PRO A HB3  1 
ATOM   2061 H HG2  . PRO A 1 132 ? -1.64618  12.68287 8.23114   1.000 22.28562  ? 132 PRO A HG2  1 
ATOM   2062 H HG3  . PRO A 1 132 ? -0.72058  13.97406 8.27013   1.000 22.28562  ? 132 PRO A HG3  1 
ATOM   2063 H HD2  . PRO A 1 132 ? -3.54311  13.89765 8.51318   1.000 23.92991  ? 132 PRO A HD2  1 
ATOM   2064 H HD3  . PRO A 1 132 ? -2.54340  14.84037 9.31147   1.000 23.92991  ? 132 PRO A HD3  1 
ATOM   2065 N N    . ASN A 1 133 ? -4.10328  15.12423 4.86792   1.000 16.04395  ? 133 ASN A N    1 
ATOM   2066 C CA   . ASN A 1 133 ? -4.87560  15.25934 3.64063   1.000 16.20755  ? 133 ASN A CA   1 
ATOM   2067 C C    . ASN A 1 133 ? -5.43886  16.66856 3.43449   1.000 15.06508  ? 133 ASN A C    1 
ATOM   2068 O O    . ASN A 1 133 ? -6.33023  16.84376 2.57979   1.000 16.19103  ? 133 ASN A O    1 
ATOM   2069 C CB   . ASN A 1 133 ? -5.98201  14.21081 3.55190   1.000 16.66334  ? 133 ASN A CB   1 
ATOM   2070 C CG   . ASN A 1 133 ? -7.07600  14.42960 4.56738   1.000 16.66159  ? 133 ASN A CG   1 
ATOM   2071 O OD1  . ASN A 1 133 ? -7.02455  15.38910 5.35652   1.000 16.44150  ? 133 ASN A OD1  1 
ATOM   2072 N ND2  . ASN A 1 133 ? -8.04622  13.54080 4.58475   1.000 19.10377  ? 133 ASN A ND2  1 
ATOM   2073 H H    . ASN A 1 133 ? -4.57073  14.90238 5.55485   1.000 19.25274  ? 133 ASN A H    1 
ATOM   2074 H HA   . ASN A 1 133 ? -4.27674  15.07883 2.89922   1.000 19.44907  ? 133 ASN A HA   1 
ATOM   2075 H HB2  . ASN A 1 133 ? -6.38119  14.24644 2.66856   1.000 19.99601  ? 133 ASN A HB2  1 
ATOM   2076 H HB3  . ASN A 1 133 ? -5.59916  13.33330 3.70780   1.000 19.99601  ? 133 ASN A HB3  1 
ATOM   2077 H HD21 . ASN A 1 133 ? -8.69324  13.62141 5.14553   1.000 22.92453  ? 133 ASN A HD21 1 
ATOM   2078 H HD22 . ASN A 1 133 ? -8.03329  12.87932 4.03531   1.000 22.92453  ? 133 ASN A HD22 1 
ATOM   2079 N N    . PHE A 1 134 ? -4.98012  17.63887 4.23602   1.000 13.03081  ? 134 PHE A N    1 
ATOM   2080 C CA   . PHE A 1 134 ? -5.30714  19.05428 4.10030   1.000 14.46373  ? 134 PHE A CA   1 
ATOM   2081 C C    . PHE A 1 134 ? -6.76043  19.36731 4.42411   1.000 16.92103  ? 134 PHE A C    1 
ATOM   2082 O O    . PHE A 1 134 ? -7.30865  20.39329 3.97240   1.000 22.87601  ? 134 PHE A O    1 
ATOM   2083 C CB   . PHE A 1 134 ? -4.99097  19.56609 2.68848   1.000 14.91416  ? 134 PHE A CB   1 
ATOM   2084 C CG   . PHE A 1 134 ? -3.51330  19.65732 2.38624   1.000 15.18622  ? 134 PHE A CG   1 
ATOM   2085 C CD1  . PHE A 1 134 ? -2.75860  20.66302 2.90081   1.000 17.36785  ? 134 PHE A CD1  1 
ATOM   2086 C CD2  . PHE A 1 134 ? -2.90552  18.70743 1.59089   1.000 18.28248  ? 134 PHE A CD2  1 
ATOM   2087 C CE1  . PHE A 1 134 ? -1.38434  20.77923 2.60611   1.000 21.39296  ? 134 PHE A CE1  1 
ATOM   2088 C CE2  . PHE A 1 134 ? -1.51283  18.78911 1.31655   1.000 19.78186  ? 134 PHE A CE2  1 
ATOM   2089 C CZ   . PHE A 1 134 ? -0.78211  19.82565 1.81418   1.000 19.32659  ? 134 PHE A CZ   1 
ATOM   2090 H H    . PHE A 1 134 ? -4.45144  17.48770 4.89727   1.000 15.63697  ? 134 PHE A H    1 
ATOM   2091 H HA   . PHE A 1 134 ? -4.75779  19.53598 4.73834   1.000 17.35647  ? 134 PHE A HA   1 
ATOM   2092 H HB2  . PHE A 1 134 ? -5.38782  18.96141 2.04212   1.000 17.89700  ? 134 PHE A HB2  1 
ATOM   2093 H HB3  . PHE A 1 134 ? -5.36841  20.45392 2.58752   1.000 17.89700  ? 134 PHE A HB3  1 
ATOM   2094 H HD1  . PHE A 1 134 ? -3.15757  21.28949 3.46050   1.000 20.84142  ? 134 PHE A HD1  1 
ATOM   2095 H HD2  . PHE A 1 134 ? -3.40843  18.01169 1.23321   1.000 21.93898  ? 134 PHE A HD2  1 
ATOM   2096 H HE1  . PHE A 1 134 ? -0.88998  21.49152 2.94249   1.000 25.67156  ? 134 PHE A HE1  1 
ATOM   2097 H HE2  . PHE A 1 134 ? -1.10127  18.13586 0.79812   1.000 23.73823  ? 134 PHE A HE2  1 
ATOM   2098 H HZ   . PHE A 1 134 ? 0.12492   19.88984 1.61906   1.000 23.19190  ? 134 PHE A HZ   1 
ATOM   2099 N N    . THR A 1 135 ? -7.40307  18.53988 5.22707   1.000 14.10935  ? 135 THR A N    1 
ATOM   2100 C CA   . THR A 1 135 ? -8.66647  18.88221 5.84289   1.000 13.86571  ? 135 THR A CA   1 
ATOM   2101 C C    . THR A 1 135 ? -8.44164  19.16240 7.31767   1.000 17.15913  ? 135 THR A C    1 
ATOM   2102 O O    . THR A 1 135 ? -7.36387  18.90354 7.85828   1.000 16.16806  ? 135 THR A O    1 
ATOM   2103 C CB   . THR A 1 135 ? -9.67890  17.73188 5.68692   1.000 13.81512  ? 135 THR A CB   1 
ATOM   2104 O OG1  . THR A 1 135 ? -9.29024  16.56401 6.39569   1.000 16.23216  ? 135 THR A OG1  1 
ATOM   2105 C CG2  . THR A 1 135 ? -9.87942  17.37854 4.22782   1.000 17.69426  ? 135 THR A CG2  1 
ATOM   2106 H H    . THR A 1 135 ? -7.11855  17.75523 5.43435   1.000 16.93122  ? 135 THR A H    1 
ATOM   2107 H HA   . THR A 1 135 ? -9.03158  19.67245 5.41498   1.000 16.63885  ? 135 THR A HA   1 
ATOM   2108 H HB   . THR A 1 135 ? -10.51874 18.04086 6.06123   1.000 16.57815  ? 135 THR A HB   1 
ATOM   2109 H HG1  . THR A 1 135 ? -8.46683  16.42949 6.29824   1.000 19.47860  ? 135 THR A HG1  1 
ATOM   2110 H HG21 . THR A 1 135 ? -10.54674 16.67952 4.14442   1.000 21.23311  ? 135 THR A HG21 1 
ATOM   2111 H HG22 . THR A 1 135 ? -10.17799 18.15913 3.73544   1.000 21.23311  ? 135 THR A HG22 1 
ATOM   2112 H HG23 . THR A 1 135 ? -9.04531  17.06479 3.84479   1.000 21.23311  ? 135 THR A HG23 1 
ATOM   2113 N N    . ILE A 1 136 ? -9.47353  19.72968 7.95982   1.000 14.43834  ? 136 ILE A N    1 
ATOM   2114 C CA   . ILE A 1 136 ? -9.48227  19.89290 9.40143   1.000 13.45823  ? 136 ILE A CA   1 
ATOM   2115 C C    . ILE A 1 136 ? -10.77272 19.29384 9.93043   1.000 14.18783  ? 136 ILE A C    1 
ATOM   2116 O O    . ILE A 1 136 ? -11.79421 19.26660 9.26157   1.000 15.90548  ? 136 ILE A O    1 
ATOM   2117 C CB   . ILE A 1 136 ? -9.29373  21.32341 9.88378   1.000 17.59090  ? 136 ILE A CB   1 
ATOM   2118 C CG1  . ILE A 1 136 ? -10.46898 22.20446 9.55565   1.000 16.20638  ? 136 ILE A CG1  1 
ATOM   2119 C CG2  . ILE A 1 136 ? -8.01452  21.88494 9.24389   1.000 19.01506  ? 136 ILE A CG2  1 
ATOM   2120 C CD1  . ILE A 1 136 ? -10.42727 23.58734 10.19014  1.000 16.43482  ? 136 ILE A CD1  1 
ATOM   2121 H H    . ILE A 1 136 ? -10.18017 20.02663 7.56983   1.000 17.32601  ? 136 ILE A H    1 
ATOM   2122 H HA   . ILE A 1 136 ? -8.72810  19.40171 9.76319   1.000 16.14988  ? 136 ILE A HA   1 
ATOM   2123 H HB   . ILE A 1 136 ? -9.22153  21.30989 10.85100  1.000 21.10908  ? 136 ILE A HB   1 
ATOM   2124 H HG12 . ILE A 1 136 ? -10.50360 22.32588 8.59391   1.000 19.44765  ? 136 ILE A HG12 1 
ATOM   2125 H HG13 . ILE A 1 136 ? -11.27763 21.76645 9.86407   1.000 19.44765  ? 136 ILE A HG13 1 
ATOM   2126 H HG21 . ILE A 1 136 ? -7.64700  22.57125 9.82251   1.000 22.81808  ? 136 ILE A HG21 1 
ATOM   2127 H HG22 . ILE A 1 136 ? -7.37330  21.16519 9.13579   1.000 22.81808  ? 136 ILE A HG22 1 
ATOM   2128 H HG23 . ILE A 1 136 ? -8.23457  22.26461 8.37882   1.000 22.81808  ? 136 ILE A HG23 1 
ATOM   2129 H HD11 . ILE A 1 136 ? -9.86175  24.16422 9.65322   1.000 19.72178  ? 136 ILE A HD11 1 
ATOM   2130 H HD12 . ILE A 1 136 ? -11.32779 23.94618 10.22479  1.000 19.72178  ? 136 ILE A HD12 1 
ATOM   2131 H HD13 . ILE A 1 136 ? -10.06632 23.51238 11.08736  1.000 19.72178  ? 136 ILE A HD13 1 
ATOM   2132 N N    . LYS A 1 137 ? -10.72061 18.78193 11.14869  1.000 15.00595  ? 137 LYS A N    1 
ATOM   2133 C CA   . LYS A 1 137 ? -11.90346 18.19045 11.80416  1.000 16.86521  ? 137 LYS A CA   1 
ATOM   2134 C C    . LYS A 1 137 ? -12.41874 19.25184 12.76024  1.000 19.22895  ? 137 LYS A C    1 
ATOM   2135 O O    . LYS A 1 137 ? -12.02922 19.32928 13.91978  1.000 19.68150  ? 137 LYS A O    1 
ATOM   2136 C CB   . LYS A 1 137 ? -11.51811 16.90406 12.51843  1.000 18.08246  ? 137 LYS A CB   1 
ATOM   2137 C CG   . LYS A 1 137 ? -11.06809 15.77318 11.59118  1.000 23.22665  ? 137 LYS A CG   1 
ATOM   2138 C CD   . LYS A 1 137 ? -10.54364 14.56716 12.38778  1.000 41.47071  ? 137 LYS A CD   1 
ATOM   2139 C CE   . LYS A 1 137 ? -10.06444 13.44735 11.45669  1.000 57.25844  ? 137 LYS A CE   1 
ATOM   2140 N NZ   . LYS A 1 137 ? -9.27387  12.40544 12.19344  1.000 66.54888  ? 137 LYS A NZ   1 
ATOM   2141 H H    . LYS A 1 137 ? -10.00886 18.75969 11.63090  1.000 18.00713  ? 137 LYS A H    1 
ATOM   2142 H HA   . LYS A 1 137 ? -12.59577 17.97693 11.15918  1.000 20.23826  ? 137 LYS A HA   1 
ATOM   2143 H HB2  . LYS A 1 137 ? -10.78525 17.09499 13.12455  1.000 21.69895  ? 137 LYS A HB2  1 
ATOM   2144 H HB3  . LYS A 1 137 ? -12.28671 16.58557 13.01714  1.000 21.69895  ? 137 LYS A HB3  1 
ATOM   2145 H HG2  . LYS A 1 137 ? -11.82029 15.47978 11.05358  1.000 27.87199  ? 137 LYS A HG2  1 
ATOM   2146 H HG3  . LYS A 1 137 ? -10.35466 16.09297 11.01703  1.000 27.87199  ? 137 LYS A HG3  1 
ATOM   2147 H HD2  . LYS A 1 137 ? -9.79616  14.84640 12.93932  1.000 49.76486  ? 137 LYS A HD2  1 
ATOM   2148 H HD3  . LYS A 1 137 ? -11.25511 14.21644 12.94609  1.000 49.76486  ? 137 LYS A HD3  1 
ATOM   2149 H HE2  . LYS A 1 137 ? -10.83399 13.01550 11.05395  1.000 68.71013  ? 137 LYS A HE2  1 
ATOM   2150 H HE3  . LYS A 1 137 ? -9.49774  13.82623 10.76662  1.000 68.71013  ? 137 LYS A HE3  1 
ATOM   2151 H HZ1  . LYS A 1 137 ? -8.56779  12.77968 12.58523  1.000 79.85865  ? 137 LYS A HZ1  1 
ATOM   2152 H HZ2  . LYS A 1 137 ? -9.78101  12.02284 12.81676  1.000 79.85865  ? 137 LYS A HZ2  1 
ATOM   2153 H HZ3  . LYS A 1 137 ? -8.99187  11.77998 11.62654  1.000 79.85865  ? 137 LYS A HZ3  1 
ATOM   2154 N N    . GLY A 1 138 ? -13.28930 20.10748 12.24942  1.000 16.88289  ? 138 GLY A N    1 
ATOM   2155 C CA   . GLY A 1 138 ? -13.77842 21.24502 12.96236  1.000 17.84448  ? 138 GLY A CA   1 
ATOM   2156 C C    . GLY A 1 138 ? -15.22128 21.08100 13.39155  1.000 16.52028  ? 138 GLY A C    1 
ATOM   2157 O O    . GLY A 1 138 ? -15.76336 19.97381 13.44646  1.000 19.10380  ? 138 GLY A O    1 
ATOM   2158 H H    . GLY A 1 138 ? -13.61759 20.03665 11.45771  1.000 20.25947  ? 138 GLY A H    1 
ATOM   2159 H HA2  . GLY A 1 138 ? -13.23748 21.38350 13.75553  1.000 21.41337  ? 138 GLY A HA2  1 
ATOM   2160 H HA3  . GLY A 1 138 ? -13.71536 22.03004 12.39609  1.000 21.41337  ? 138 GLY A HA3  1 
ATOM   2161 N N    . SER A 1 139 ? -15.83143 22.20229 13.74495  1.000 16.47821  ? 139 SER A N    1 
ATOM   2162 C CA   . SER A 1 139 ? -17.23400 22.25720 14.11945  1.000 13.54233  ? 139 SER A CA   1 
ATOM   2163 C C    . SER A 1 139 ? -17.75461 23.54051 13.49980  1.000 17.31102  ? 139 SER A C    1 
ATOM   2164 O O    . SER A 1 139 ? -17.50829 24.62551 14.01161  1.000 16.93744  ? 139 SER A O    1 
ATOM   2165 C CB   . SER A 1 139 ? -17.42445 22.24896 15.61842  1.000 18.65066  ? 139 SER A CB   1 
ATOM   2166 O OG   . SER A 1 139 ? -18.78689 22.43896 15.93293  1.000 20.86720  ? 139 SER A OG   1 
ATOM   2167 H H    . SER A 1 139 ? -15.44133 22.96808 13.77637  1.000 19.77385  ? 139 SER A H    1 
ATOM   2168 H HA   . SER A 1 139 ? -17.71207 21.48938 13.76901  1.000 16.25079  ? 139 SER A HA   1 
ATOM   2169 H HB2  . SER A 1 139 ? -17.13128 21.39488 15.97266  1.000 22.38079  ? 139 SER A HB2  1 
ATOM   2170 H HB3  . SER A 1 139 ? -16.90333 22.96715 16.01026  1.000 22.38079  ? 139 SER A HB3  1 
ATOM   2171 H HG   . SER A 1 139 ? -19.24724 21.81901 15.60228  1.000 25.04064  ? 139 SER A HG   1 
ATOM   2172 N N    . PHE A 1 140 ? -18.44161 23.40393 12.35736  1.000 17.13088  ? 140 PHE A N    1 
ATOM   2173 C CA   . PHE A 1 140 ? -18.84432 24.55990 11.57249  1.000 17.66061  ? 140 PHE A CA   1 
ATOM   2174 C C    . PHE A 1 140 ? -20.24916 24.30234 11.01528  1.000 23.38967  ? 140 PHE A C    1 
ATOM   2175 O O    . PHE A 1 140 ? -20.49963 23.23912 10.43114  1.000 21.63215  ? 140 PHE A O    1 
ATOM   2176 C CB   . PHE A 1 140 ? -17.91552 24.72957 10.37370  1.000 17.69979  ? 140 PHE A CB   1 
ATOM   2177 C CG   . PHE A 1 140 ? -16.51212 25.18661 10.68465  1.000 17.98182  ? 140 PHE A CG   1 
ATOM   2178 C CD1  . PHE A 1 140 ? -16.24208 26.48628 11.03238  1.000 25.17968  ? 140 PHE A CD1  1 
ATOM   2179 C CD2  . PHE A 1 140 ? -15.47303 24.31163 10.57457  1.000 16.40558  ? 140 PHE A CD2  1 
ATOM   2180 C CE1  . PHE A 1 140 ? -14.93390 26.90384 11.26972  1.000 28.38823  ? 140 PHE A CE1  1 
ATOM   2181 C CE2  . PHE A 1 140 ? -14.17192 24.71259 10.82299  1.000 18.60457  ? 140 PHE A CE2  1 
ATOM   2182 C CZ   . PHE A 1 140 ? -13.90847 26.00580 11.12723  1.000 16.43818  ? 140 PHE A CZ   1 
ATOM   2183 H H    . PHE A 1 140 ? -18.68223 22.64896 12.02312  1.000 20.55706  ? 140 PHE A H    1 
ATOM   2184 H HA   . PHE A 1 140 ? -18.83805 25.35183 12.13259  1.000 21.19274  ? 140 PHE A HA   1 
ATOM   2185 H HB2  . PHE A 1 140 ? -17.84474 23.87435 9.92150   1.000 21.23974  ? 140 PHE A HB2  1 
ATOM   2186 H HB3  . PHE A 1 140 ? -18.30607 25.38832 9.77836   1.000 21.23974  ? 140 PHE A HB3  1 
ATOM   2187 H HD1  . PHE A 1 140 ? -16.94030 27.09561 11.11058  1.000 30.21561  ? 140 PHE A HD1  1 
ATOM   2188 H HD2  . PHE A 1 140 ? -15.64106 23.43066 10.32849  1.000 19.68670  ? 140 PHE A HD2  1 
ATOM   2189 H HE1  . PHE A 1 140 ? -14.75876 27.78170 11.52189  1.000 34.06588  ? 140 PHE A HE1  1 
ATOM   2190 H HE2  . PHE A 1 140 ? -13.47862 24.09414 10.78101  1.000 22.32548  ? 140 PHE A HE2  1 
ATOM   2191 H HZ   . PHE A 1 140 ? -13.02866 26.28538 11.23983  1.000 19.72581  ? 140 PHE A HZ   1 
ATOM   2192 N N    . LEU A 1 141 ? -21.13098 25.27636 11.14907  1.000 20.22710  ? 141 LEU A N    1 
ATOM   2193 C CA   . LEU A 1 141 ? -22.49893 25.18498 10.64775  1.000 22.74469  ? 141 LEU A CA   1 
ATOM   2194 C C    . LEU A 1 141 ? -22.67767 26.21228 9.54183   1.000 21.36245  ? 141 LEU A C    1 
ATOM   2195 O O    . LEU A 1 141 ? -21.79400 27.00718 9.23711   1.000 21.11967  ? 141 LEU A O    1 
ATOM   2196 C CB   . LEU A 1 141 ? -23.50028 25.42350 11.77754  1.000 21.39353  ? 141 LEU A CB   1 
ATOM   2197 C CG   . LEU A 1 141 ? -23.38535 24.48408 12.98124  1.000 29.65541  ? 141 LEU A CG   1 
ATOM   2198 C CD1  . LEU A 1 141 ? -24.21749 24.99484 14.13584  1.000 34.51747  ? 141 LEU A CD1  1 
ATOM   2199 C CD2  . LEU A 1 141 ? -23.79285 23.09126 12.60042  1.000 25.25441  ? 141 LEU A CD2  1 
ATOM   2200 H H    . LEU A 1 141 ? -20.95926 26.02407 11.53772  1.000 24.27252  ? 141 LEU A H    1 
ATOM   2201 H HA   . LEU A 1 141 ? -22.65687 24.29725 10.29014  1.000 27.29363  ? 141 LEU A HA   1 
ATOM   2202 H HB2  . LEU A 1 141 ? -23.37711 26.32799 12.10559  1.000 25.67223  ? 141 LEU A HB2  1 
ATOM   2203 H HB3  . LEU A 1 141 ? -24.39465 25.32047 11.41643  1.000 25.67223  ? 141 LEU A HB3  1 
ATOM   2204 H HG   . LEU A 1 141 ? -22.46108 24.45401 13.27401  1.000 35.58649  ? 141 LEU A HG   1 
ATOM   2205 H HD11 . LEU A 1 141 ? -25.00733 24.43904 14.22604  1.000 41.42097  ? 141 LEU A HD11 1 
ATOM   2206 H HD12 . LEU A 1 141 ? -23.68933 24.95344 14.94839  1.000 41.42097  ? 141 LEU A HD12 1 
ATOM   2207 H HD13 . LEU A 1 141 ? -24.47718 25.91206 13.95650  1.000 41.42097  ? 141 LEU A HD13 1 
ATOM   2208 H HD21 . LEU A 1 141 ? -23.75442 22.52480 13.38689  1.000 30.30529  ? 141 LEU A HD21 1 
ATOM   2209 H HD22 . LEU A 1 141 ? -24.69753 23.11128 12.25107  1.000 30.30529  ? 141 LEU A HD22 1 
ATOM   2210 H HD23 . LEU A 1 141 ? -23.18390 22.75819 11.92281  1.000 30.30529  ? 141 LEU A HD23 1 
ATOM   2211 N N    . ASN A 1 142 ? -23.86010 26.20285 8.92289   1.000 25.70365  ? 142 ASN A N    1 
ATOM   2212 C CA   . ASN A 1 142 ? -24.15003 27.25463 7.95549   1.000 22.67218  ? 142 ASN A CA   1 
ATOM   2213 C C    . ASN A 1 142 ? -23.95381 28.61943 8.61826   1.000 16.74435  ? 142 ASN A C    1 
ATOM   2214 O O    . ASN A 1 142 ? -24.31856 28.83861 9.78141   1.000 20.97970  ? 142 ASN A O    1 
ATOM   2215 C CB   . ASN A 1 142 ? -25.58277 27.09878 7.45348   1.000 32.50080  ? 142 ASN A CB   1 
ATOM   2216 C CG   . ASN A 1 142 ? -25.66695 26.15161 6.29819   1.000 40.25587  ? 142 ASN A CG   1 
ATOM   2217 O OD1  . ASN A 1 142 ? -26.03858 24.98616 6.45983   1.000 63.35199  ? 142 ASN A OD1  1 
ATOM   2218 N ND2  . ASN A 1 142 ? -25.29890 26.63271 5.11370   1.000 57.92153  ? 142 ASN A ND2  1 
ATOM   2219 H H    . ASN A 1 142 ? -24.48322 25.62224 9.04214   1.000 30.84438  ? 142 ASN A H    1 
ATOM   2220 H HA   . ASN A 1 142 ? -23.55682 27.19470 7.19037   1.000 27.20662  ? 142 ASN A HA   1 
ATOM   2221 H HB2  . ASN A 1 142 ? -26.13710 26.75345 8.17068   1.000 39.00096  ? 142 ASN A HB2  1 
ATOM   2222 H HB3  . ASN A 1 142 ? -25.91566 27.96244 7.16334   1.000 39.00096  ? 142 ASN A HB3  1 
ATOM   2223 H HD21 . ASN A 1 142 ? -25.32847 26.12929 4.41707   1.000 69.50583  ? 142 ASN A HD21 1 
ATOM   2224 H HD22 . ASN A 1 142 ? -25.03140 27.44713 5.04464   1.000 69.50583  ? 142 ASN A HD22 1 
ATOM   2225 N N    . GLY A 1 143 ? -23.33669 29.53711 7.85989   1.000 19.35083  ? 143 GLY A N    1 
ATOM   2226 C CA   . GLY A 1 143 ? -23.05522 30.85724 8.36119   1.000 21.06532  ? 143 GLY A CA   1 
ATOM   2227 C C    . GLY A 1 143 ? -21.65267 31.02454 8.91099   1.000 20.74418  ? 143 GLY A C    1 
ATOM   2228 O O    . GLY A 1 143 ? -21.26303 32.13605 9.19481   1.000 19.18382  ? 143 GLY A O    1 
ATOM   2229 H H    . GLY A 1 143 ? -23.07673 29.40299 7.05117   1.000 23.22099  ? 143 GLY A H    1 
ATOM   2230 H HA2  . GLY A 1 143 ? -23.17284 31.49749 7.64207   1.000 25.27838  ? 143 GLY A HA2  1 
ATOM   2231 H HA3  . GLY A 1 143 ? -23.68175 31.06276 9.07261   1.000 25.27838  ? 143 GLY A HA3  1 
ATOM   2232 N N    . SER A 1 144 ? -20.89075 29.93451 9.02122   1.000 17.06802  ? 144 SER A N    1 
ATOM   2233 C CA   . SER A 1 144 ? -19.57954 29.98249 9.67473   1.000 17.02311  ? 144 SER A CA   1 
ATOM   2234 C C    . SER A 1 144 ? -18.45271 30.36432 8.72359   1.000 15.73790  ? 144 SER A C    1 
ATOM   2235 O O    . SER A 1 144 ? -17.34628 30.64502 9.20393   1.000 13.54081  ? 144 SER A O    1 
ATOM   2236 C CB   . SER A 1 144 ? -19.25385 28.59773 10.24445  1.000 14.04695  ? 144 SER A CB   1 
ATOM   2237 O OG   . SER A 1 144 ? -19.14446 27.62805 9.29060   1.000 17.70389  ? 144 SER A OG   1 
ATOM   2238 H H    . SER A 1 144 ? -21.10990 29.15689 8.72646   1.000 20.48163  ? 144 SER A H    1 
ATOM   2239 H HA   . SER A 1 144 ? -19.61349 30.63500 10.39165  1.000 20.42773  ? 144 SER A HA   1 
ATOM   2240 H HB2  . SER A 1 144 ? -18.41025 28.65432 10.71988  1.000 16.85633  ? 144 SER A HB2  1 
ATOM   2241 H HB3  . SER A 1 144 ? -19.96307 28.34514 10.85609  1.000 16.85633  ? 144 SER A HB3  1 
ATOM   2242 H HG   . SER A 1 144 ? -19.81761 27.64189 8.78832   1.000 21.24467  ? 144 SER A HG   1 
ATOM   2243 N N    . CYS A 1 145 ? -18.71171 30.35518 7.40372   1.000 17.04473  ? 145 CYS A N    1 
ATOM   2244 C CA   . CYS A 1 145 ? -17.66695 30.72284 6.45742   1.000 15.07412  ? 145 CYS A CA   1 
ATOM   2245 C C    . CYS A 1 145 ? -17.08888 32.09085 6.79283   1.000 13.23596  ? 145 CYS A C    1 
ATOM   2246 O O    . CYS A 1 145 ? -17.76323 33.01234 7.28099   1.000 15.87302  ? 145 CYS A O    1 
ATOM   2247 C CB   . CYS A 1 145 ? -18.19174 30.65839 5.02173   1.000 17.09219  ? 145 CYS A CB   1 
ATOM   2248 S SG   . CYS A 1 145 ? -18.35866 28.95860 4.56316   1.000 19.40120  ? 145 CYS A SG   1 
ATOM   2249 H H    . CYS A 1 145 ? -19.46623 30.14443 7.04894   1.000 20.45367  ? 145 CYS A H    1 
ATOM   2250 H HA   . CYS A 1 145 ? -16.93646 30.08731 6.51552   1.000 18.08894  ? 145 CYS A HA   1 
ATOM   2251 H HB2  . CYS A 1 145 ? -19.05855 31.09010 4.96532   1.000 20.51063  ? 145 CYS A HB2  1 
ATOM   2252 H HB3  . CYS A 1 145 ? -17.56599 31.09072 4.41971   1.000 20.51063  ? 145 CYS A HB3  1 
ATOM   2253 N N    . GLY A 1 146 ? -15.79318 32.24699 6.56172   1.000 11.66473  ? 146 GLY A N    1 
ATOM   2254 C CA   . GLY A 1 146 ? -15.07240 33.41510 6.92559   1.000 14.99217  ? 146 GLY A CA   1 
ATOM   2255 C C    . GLY A 1 146 ? -14.51443 33.37541 8.33145   1.000 15.40603  ? 146 GLY A C    1 
ATOM   2256 O O    . GLY A 1 146 ? -13.72719 34.26700 8.68338   1.000 15.56365  ? 146 GLY A O    1 
ATOM   2257 H H    . GLY A 1 146 ? -15.30304 31.65402 6.17733   1.000 13.99767  ? 146 GLY A H    1 
ATOM   2258 H HA2  . GLY A 1 146 ? -14.33078 33.53143 6.31128   1.000 17.99060  ? 146 GLY A HA2  1 
ATOM   2259 H HA3  . GLY A 1 146 ? -15.66185 34.18248 6.85795   1.000 17.99060  ? 146 GLY A HA3  1 
ATOM   2260 N N    . SER A 1 147 ? -14.89840 32.37945 9.14424   1.000 16.33891  ? 147 SER A N    1 
ATOM   2261 C CA   . SER A 1 147 ? -14.22138 32.17047 10.43886  1.000 13.10659  ? 147 SER A CA   1 
ATOM   2262 C C    . SER A 1 147 ? -12.75929 31.85604 10.17629  1.000 14.27339  ? 147 SER A C    1 
ATOM   2263 O O    . SER A 1 147 ? -12.42296 31.26444 9.12648   1.000 14.73380  ? 147 SER A O    1 
ATOM   2264 C CB   . SER A 1 147 ? -14.81203 30.98084 11.17863  1.000 15.85310  ? 147 SER A CB   1 
ATOM   2265 O OG   . SER A 1 147 ? -16.14889 31.24012 11.56191  1.000 17.26926  ? 147 SER A OG   1 
ATOM   2266 H H    . SER A 1 147 ? -15.53228 31.82313 8.97599   1.000 19.60670  ? 147 SER A H    1 
ATOM   2267 H HA   . SER A 1 147 ? -14.32460 32.96485 10.98584  1.000 15.72791  ? 147 SER A HA   1 
ATOM   2268 H HB2  . SER A 1 147 ? -14.79535 30.20612 10.59517  1.000 19.02372  ? 147 SER A HB2  1 
ATOM   2269 H HB3  . SER A 1 147 ? -14.28327 30.80899 11.97348  1.000 19.02372  ? 147 SER A HB3  1 
ATOM   2270 H HG   . SER A 1 147 ? -16.67010 31.05466 10.92982  1.000 20.72311  ? 147 SER A HG   1 
ATOM   2271 N N    . VAL A 1 148 ? -11.88809 32.24692 11.09568  1.000 14.09154  ? 148 VAL A N    1 
ATOM   2272 C CA   . VAL A 1 148 ? -10.46265 32.12890 10.85692  1.000 13.52030  ? 148 VAL A CA   1 
ATOM   2273 C C    . VAL A 1 148 ? -9.76524  31.24497 11.88017  1.000 12.46743  ? 148 VAL A C    1 
ATOM   2274 O O    . VAL A 1 148 ? -10.23086 31.09819 13.02360  1.000 14.55855  ? 148 VAL A O    1 
ATOM   2275 C CB   . VAL A 1 148 ? -9.71506  33.47099 10.71836  1.000 15.36396  ? 148 VAL A CB   1 
ATOM   2276 C CG1  . VAL A 1 148 ? -10.24571 34.23032 9.50543   1.000 16.80968  ? 148 VAL A CG1  1 
ATOM   2277 C CG2  . VAL A 1 148 ? -9.81507  34.27542 12.01496  1.000 17.04186  ? 148 VAL A CG2  1 
ATOM   2278 H H    . VAL A 1 148 ? -12.09962 32.58096 11.85940  1.000 16.90985  ? 148 VAL A H    1 
ATOM   2279 H HA   . VAL A 1 148 ? -10.40971 31.66738 10.00539  1.000 16.22435  ? 148 VAL A HA   1 
ATOM   2280 H HB   . VAL A 1 148 ? -8.76945  33.31612 10.56761  1.000 18.43675  ? 148 VAL A HB   1 
ATOM   2281 H HG11 . VAL A 1 148 ? -11.19209 34.04287 9.40473   1.000 20.17161  ? 148 VAL A HG11 1 
ATOM   2282 H HG12 . VAL A 1 148 ? -10.10963 35.18075 9.64352   1.000 20.17161  ? 148 VAL A HG12 1 
ATOM   2283 H HG13 . VAL A 1 148 ? -9.76482  33.93871 8.71511   1.000 20.17161  ? 148 VAL A HG13 1 
ATOM   2284 H HG21 . VAL A 1 148 ? -8.93141  34.59259 12.25878  1.000 20.45023  ? 148 VAL A HG21 1 
ATOM   2285 H HG22 . VAL A 1 148 ? -10.40970 35.02874 11.87417  1.000 20.45023  ? 148 VAL A HG22 1 
ATOM   2286 H HG23 . VAL A 1 148 ? -10.16605 33.70333 12.71527  1.000 20.45023  ? 148 VAL A HG23 1 
ATOM   2287 N N    . GLY A 1 149 ? -8.63359  30.66438 11.45023  1.000 16.07628  ? 149 GLY A N    1 
ATOM   2288 C CA   . GLY A 1 149 ? -7.70846  29.97165 12.31399  1.000 15.06801  ? 149 GLY A CA   1 
ATOM   2289 C C    . GLY A 1 149 ? -6.41144  30.74697 12.45054  1.000 13.26894  ? 149 GLY A C    1 
ATOM   2290 O O    . GLY A 1 149 ? -5.97455  31.45219 11.51358  1.000 14.81372  ? 149 GLY A O    1 
ATOM   2291 H H    . GLY A 1 149 ? -8.38373  30.66683 10.62733  1.000 19.29153  ? 149 GLY A H    1 
ATOM   2292 H HA2  . GLY A 1 149 ? -8.10105  29.86353 13.19438  1.000 18.08161  ? 149 GLY A HA2  1 
ATOM   2293 H HA3  . GLY A 1 149 ? -7.51083  29.09593 11.94662  1.000 18.08161  ? 149 GLY A HA3  1 
ATOM   2294 N N    . PHE A 1 150 ? -5.76437  30.60422 13.61652  1.000 13.87718  ? 150 PHE A N    1 
ATOM   2295 C CA   . PHE A 1 150 ? -4.66043  31.48091 13.92450  1.000 14.38867  ? 150 PHE A CA   1 
ATOM   2296 C C    . PHE A 1 150 ? -3.81656  30.86925 15.04344  1.000 14.74636  ? 150 PHE A C    1 
ATOM   2297 O O    . PHE A 1 150 ? -4.28326  30.00221 15.79017  1.000 13.62784  ? 150 PHE A O    1 
ATOM   2298 C CB   . PHE A 1 150 ? -5.18703  32.86435 14.37365  1.000 17.97044  ? 150 PHE A CB   1 
ATOM   2299 C CG   . PHE A 1 150 ? -6.03608  32.80626 15.58705  1.000 18.45809  ? 150 PHE A CG   1 
ATOM   2300 C CD1  . PHE A 1 150 ? -7.37663  32.48687 15.49494  1.000 19.32671  ? 150 PHE A CD1  1 
ATOM   2301 C CD2  . PHE A 1 150 ? -5.47999  33.03455 16.83960  1.000 20.42255  ? 150 PHE A CD2  1 
ATOM   2302 C CE1  . PHE A 1 150 ? -8.15126  32.38904 16.65635  1.000 20.38866  ? 150 PHE A CE1  1 
ATOM   2303 C CE2  . PHE A 1 150 ? -6.27280  32.95096 17.99486  1.000 20.17465  ? 150 PHE A CE2  1 
ATOM   2304 C CZ   . PHE A 1 150 ? -7.61444  32.63884 17.86356  1.000 20.65232  ? 150 PHE A CZ   1 
ATOM   2305 H H    . PHE A 1 150 ? -5.95081  30.01986 14.21932  1.000 16.65262  ? 150 PHE A H    1 
ATOM   2306 H HA   . PHE A 1 150 ? -4.09779  31.57436 13.13989  1.000 17.26640  ? 150 PHE A HA   1 
ATOM   2307 H HB2  . PHE A 1 150 ? -4.43041  33.43961 14.56733  1.000 21.56453  ? 150 PHE A HB2  1 
ATOM   2308 H HB3  . PHE A 1 150 ? -5.71827  33.24499 13.65686  1.000 21.56453  ? 150 PHE A HB3  1 
ATOM   2309 H HD1  . PHE A 1 150 ? -7.76377  32.33710 14.66272  1.000 23.19206  ? 150 PHE A HD1  1 
ATOM   2310 H HD2  . PHE A 1 150 ? -4.57687  33.24403 16.91305  1.000 24.50706  ? 150 PHE A HD2  1 
ATOM   2311 H HE1  . PHE A 1 150 ? -9.04736  32.14856 16.59247  1.000 24.46639  ? 150 PHE A HE1  1 
ATOM   2312 H HE2  . PHE A 1 150 ? -5.90261  33.10280 18.83439  1.000 24.20958  ? 150 PHE A HE2  1 
ATOM   2313 H HZ   . PHE A 1 150 ? -8.15257  32.60130 18.62113  1.000 24.78279  ? 150 PHE A HZ   1 
ATOM   2314 N N    . ASN A 1 151 ? -2.57078  31.33086 15.13086  1.000 13.36567  ? 151 ASN A N    1 
ATOM   2315 C CA   . ASN A 1 151 ? -1.70163  31.11342 16.29660  1.000 13.86294  ? 151 ASN A CA   1 
ATOM   2316 C C    . ASN A 1 151 ? -1.25983  32.48384 16.78635  1.000 16.28690  ? 151 ASN A C    1 
ATOM   2317 O O    . ASN A 1 151 ? -1.26265  33.47081 16.04862  1.000 16.88926  ? 151 ASN A O    1 
ATOM   2318 C CB   . ASN A 1 151 ? -0.50525  30.27384 15.93001  1.000 15.41201  ? 151 ASN A CB   1 
ATOM   2319 C CG   . ASN A 1 151 ? -0.82661  28.81281 15.70350  1.000 21.49224  ? 151 ASN A CG   1 
ATOM   2320 O OD1  . ASN A 1 151 ? -0.94254  28.05231 16.66366  1.000 23.50540  ? 151 ASN A OD1  1 
ATOM   2321 N ND2  . ASN A 1 151 ? -1.01349  28.41308 14.46832  1.000 18.38492  ? 151 ASN A ND2  1 
ATOM   2322 H H    . ASN A 1 151 ? -2.19041  31.78816 14.50974  1.000 16.03881  ? 151 ASN A H    1 
ATOM   2323 H HA   . ASN A 1 151 ? -2.16926  30.64750 17.00733  1.000 16.63553  ? 151 ASN A HA   1 
ATOM   2324 H HB2  . ASN A 1 151 ? -0.11999  30.62153 15.11050  1.000 18.49441  ? 151 ASN A HB2  1 
ATOM   2325 H HB3  . ASN A 1 151 ? 0.14345   30.32501 16.64936  1.000 18.49441  ? 151 ASN A HB3  1 
ATOM   2326 H HD21 . ASN A 1 151 ? -1.19768  27.58880 14.30633  1.000 22.06191  ? 151 ASN A HD21 1 
ATOM   2327 H HD22 . ASN A 1 151 ? -0.95184  28.97526 13.82044  1.000 22.06191  ? 151 ASN A HD22 1 
ATOM   2328 N N    . ILE A 1 152 ? -0.87250  32.58054 18.06810  1.000 16.07205  ? 152 ILE A N    1 
ATOM   2329 C CA   . ILE A 1 152 ? -0.38494  33.83468 18.61866  1.000 19.56618  ? 152 ILE A CA   1 
ATOM   2330 C C    . ILE A 1 152 ? 0.99197   33.57789 19.20718  1.000 23.74716  ? 152 ILE A C    1 
ATOM   2331 O O    . ILE A 1 152 ? 1.18375   32.61280 19.94260  1.000 25.62890  ? 152 ILE A O    1 
ATOM   2332 C CB   . ILE A 1 152 ? -1.32486  34.41884 19.67450  1.000 23.39560  ? 152 ILE A CB   1 
ATOM   2333 C CG1  . ILE A 1 152 ? -2.72805  34.60429 19.11583  1.000 24.69519  ? 152 ILE A CG1  1 
ATOM   2334 C CG2  . ILE A 1 152 ? -0.77681  35.76995 20.16922  1.000 25.98133  ? 152 ILE A CG2  1 
ATOM   2335 C CD1  . ILE A 1 152 ? -3.69980  35.28160 20.06863  1.000 34.40987  ? 152 ILE A CD1  1 
ATOM   2336 H H    . ILE A 1 152 ? -0.88685  31.92878 18.62900  1.000 19.28646  ? 152 ILE A H    1 
ATOM   2337 H HA   . ILE A 1 152 ? -0.30906  34.48506 17.90302  1.000 23.47941  ? 152 ILE A HA   1 
ATOM   2338 H HB   . ILE A 1 152 ? -1.37253  33.79401 20.41492  1.000 28.07472  ? 152 ILE A HB   1 
ATOM   2339 H HG12 . ILE A 1 152 ? -2.67283  35.15051 18.31614  1.000 29.63423  ? 152 ILE A HG12 1 
ATOM   2340 H HG13 . ILE A 1 152 ? -3.09170  33.73199 18.89732  1.000 29.63423  ? 152 ILE A HG13 1 
ATOM   2341 H HG21 . ILE A 1 152 ? -0.84989  36.42129 19.45416  1.000 31.17759  ? 152 ILE A HG21 1 
ATOM   2342 H HG22 . ILE A 1 152 ? -1.29633  36.06005 20.93527  1.000 31.17759  ? 152 ILE A HG22 1 
ATOM   2343 H HG23 . ILE A 1 152 ? 0.15301   35.65987 20.42264  1.000 31.17759  ? 152 ILE A HG23 1 
ATOM   2344 H HD11 . ILE A 1 152 ? -3.49488  36.22888 20.10809  1.000 41.29185  ? 152 ILE A HD11 1 
ATOM   2345 H HD12 . ILE A 1 152 ? -4.60404  35.15209 19.74231  1.000 41.29185  ? 152 ILE A HD12 1 
ATOM   2346 H HD13 . ILE A 1 152 ? -3.60611  34.88594 20.94929  1.000 41.29185  ? 152 ILE A HD13 1 
ATOM   2347 N N    . ASP A 1 153 ? 1.95401   34.40264 18.82263  1.000 27.23759  ? 153 ASP A N    1 
ATOM   2348 C CA   . ASP A 1 153 ? 3.31757   34.34601 19.36189  1.000 29.88544  ? 153 ASP A CA   1 
ATOM   2349 C C    . ASP A 1 153 ? 3.64236   35.74562 19.85546  1.000 37.15758  ? 153 ASP A C    1 
ATOM   2350 O O    . ASP A 1 153 ? 3.64506   36.69957 19.06863  1.000 33.75522  ? 153 ASP A O    1 
ATOM   2351 C CB   . ASP A 1 153 ? 4.32405   33.90824 18.29681  1.000 29.58821  ? 153 ASP A CB   1 
ATOM   2352 H H    . ASP A 1 153 ? 1.84516   35.02181 18.23580  1.000 32.68510  ? 153 ASP A H    1 
ATOM   2353 H HA   . ASP A 1 153 ? 3.37138   33.71148 20.09359  1.000 35.86253  ? 153 ASP A HA   1 
ATOM   2354 N N    . TYR A 1 154 ? 3.88943   35.87423 21.15973  1.000 33.66859  ? 154 TYR A N    1 
ATOM   2355 C CA   . TYR A 1 154 ? 4.08575   37.17441 21.79230  1.000 38.32309  ? 154 TYR A CA   1 
ATOM   2356 C C    . TYR A 1 154 ? 2.80632   37.96622 21.56672  1.000 38.34924  ? 154 TYR A C    1 
ATOM   2357 O O    . TYR A 1 154 ? 1.74243   37.54283 22.05341  1.000 42.97071  ? 154 TYR A O    1 
ATOM   2358 C CB   . TYR A 1 154 ? 5.38720   37.78120 21.26473  1.000 36.35546  ? 154 TYR A CB   1 
ATOM   2359 H H    . TYR A 1 154 ? 3.94835   35.21142 21.70453  1.000 40.40231  ? 154 TYR A H    1 
ATOM   2360 H HA   . TYR A 1 154 ? 4.18872   37.07022 22.75118  1.000 45.98770  ? 154 TYR A HA   1 
ATOM   2361 N N    . ASP A 1 155 ? 2.83525   39.08227 20.85159  1.000 29.23660  ? 155 ASP A N    1 
ATOM   2362 C CA   . ASP A 1 155 ? 1.63847   39.88900 20.64218  1.000 35.69111  ? 155 ASP A CA   1 
ATOM   2363 C C    . ASP A 1 155 ? 1.14739   39.83351 19.19138  1.000 27.23016  ? 155 ASP A C    1 
ATOM   2364 O O    . ASP A 1 155 ? 0.28546   40.62558 18.80629  1.000 29.50578  ? 155 ASP A O    1 
ATOM   2365 C CB   . ASP A 1 155 ? 1.93320   41.34062 21.03109  1.000 52.60908  ? 155 ASP A CB   1 
ATOM   2366 C CG   . ASP A 1 155 ? 3.16121   41.88681 20.31293  1.000 71.09203  ? 155 ASP A CG   1 
ATOM   2367 O OD1  . ASP A 1 155 ? 3.98634   41.05770 19.84987  1.000 57.68635  ? 155 ASP A OD1  1 
ATOM   2368 O OD2  . ASP A 1 155 ? 3.29710   43.12700 20.20864  1.000 69.60035  ? 155 ASP A OD2  1 
ATOM   2369 H H    . ASP A 1 155 ? 3.54116   39.39650 20.47403  1.000 35.08392  ? 155 ASP A H    1 
ATOM   2370 H HA   . ASP A 1 155 ? 0.92685   39.55289 21.20921  1.000 42.82933  ? 155 ASP A HA   1 
ATOM   2371 H HB2  . ASP A 1 155 ? 1.17277   41.89465 20.79508  1.000 63.13090  ? 155 ASP A HB2  1 
ATOM   2372 H HB3  . ASP A 1 155 ? 2.09465   41.38832 21.98636  1.000 63.13090  ? 155 ASP A HB3  1 
ATOM   2373 N N    . CYS A 1 156 ? 1.66474   38.90969 18.41266  1.000 23.46409  ? 156 CYS A N    1 
ATOM   2374 C CA   . CYS A 1 156 ? 1.43988   38.89419 16.94802  1.000 23.49990  ? 156 CYS A CA   1 
ATOM   2375 C C    . CYS A 1 156 ? 0.55366   37.71258 16.57776  1.000 20.12984  ? 156 CYS A C    1 
ATOM   2376 O O    . CYS A 1 156 ? 0.87164   36.56250 16.92076  1.000 19.62940  ? 156 CYS A O    1 
ATOM   2377 C CB   . CYS A 1 156 ? 2.78516   38.77484 16.24561  1.000 23.76392  ? 156 CYS A CB   1 
ATOM   2378 S SG   . CYS A 1 156 ? 2.69855   38.66596 14.42335  1.000 25.92626  ? 156 CYS A SG   1 
ATOM   2379 H H    . CYS A 1 156 ? 2.15874   38.26488 18.69513  1.000 28.15691  ? 156 CYS A H    1 
ATOM   2380 H HA   . CYS A 1 156 ? 0.98215   39.70347 16.67154  1.000 28.19988  ? 156 CYS A HA   1 
ATOM   2381 H HB2  . CYS A 1 156 ? 3.31640   39.55611 16.46537  1.000 28.51670  ? 156 CYS A HB2  1 
ATOM   2382 H HB3  . CYS A 1 156 ? 3.22752   37.97252 16.56422  1.000 28.51670  ? 156 CYS A HB3  1 
ATOM   2383 H HG   . CYS A 1 156 ? 3.81133   38.57141 13.98429  1.000 31.11151  ? 156 CYS A HG   1 
ATOM   2384 N N    . VAL A 1 157 ? -0.55847  38.00369 15.89885  1.000 17.93064  ? 157 VAL A N    1 
ATOM   2385 C CA   . VAL A 1 157 ? -1.47612  36.98008 15.44342  1.000 16.87196  ? 157 VAL A CA   1 
ATOM   2386 C C    . VAL A 1 157 ? -1.02300  36.52230 14.05140  1.000 17.18769  ? 157 VAL A C    1 
ATOM   2387 O O    . VAL A 1 157 ? -0.96890  37.32994 13.10631  1.000 18.09734  ? 157 VAL A O    1 
ATOM   2388 C CB   . VAL A 1 157 ? -2.91147  37.49436 15.37191  1.000 17.15142  ? 157 VAL A CB   1 
ATOM   2389 C CG1  . VAL A 1 157 ? -3.88120  36.38381 14.94710  1.000 19.02704  ? 157 VAL A CG1  1 
ATOM   2390 C CG2  . VAL A 1 157 ? -3.34606  38.10702 16.72242  1.000 20.30397  ? 157 VAL A CG2  1 
ATOM   2391 H H    . VAL A 1 157 ? -0.79975  38.80244 15.69059  1.000 21.51677  ? 157 VAL A H    1 
ATOM   2392 H HA   . VAL A 1 157 ? -1.44182  36.23516 16.06375  1.000 20.24635  ? 157 VAL A HA   1 
ATOM   2393 H HB   . VAL A 1 157 ? -2.94653  38.19139 14.69826  1.000 20.58170  ? 157 VAL A HB   1 
ATOM   2394 H HG11 . VAL A 1 157 ? -4.79139  36.70320 15.04928  1.000 22.83245  ? 157 VAL A HG11 1 
ATOM   2395 H HG12 . VAL A 1 157 ? -3.71296  36.15543 14.01950  1.000 22.83245  ? 157 VAL A HG12 1 
ATOM   2396 H HG13 . VAL A 1 157 ? -3.73803  35.60708 15.51020  1.000 22.83245  ? 157 VAL A HG13 1 
ATOM   2397 H HG21 . VAL A 1 157 ? -4.29335  38.31245 16.68576  1.000 24.36476  ? 157 VAL A HG21 1 
ATOM   2398 H HG22 . VAL A 1 157 ? -3.17370  37.46623 17.42995  1.000 24.36476  ? 157 VAL A HG22 1 
ATOM   2399 H HG23 . VAL A 1 157 ? -2.83757  38.91798 16.87953  1.000 24.36476  ? 157 VAL A HG23 1 
ATOM   2400 N N    . SER A 1 158 ? -0.72855  35.22869 13.92010  1.000 16.25819  ? 158 SER A N    1 
ATOM   2401 C CA   . SER A 1 158 ? -0.40311  34.63405 12.61775  1.000 15.66927  ? 158 SER A CA   1 
ATOM   2402 C C    . SER A 1 158 ? -1.66566  33.92202 12.14186  1.000 17.62134  ? 158 SER A C    1 
ATOM   2403 O O    . SER A 1 158 ? -2.01078  32.84255 12.64705  1.000 16.61322  ? 158 SER A O    1 
ATOM   2404 C CB   . SER A 1 158 ? 0.75164   33.67196 12.72348  1.000 18.50279  ? 158 SER A CB   1 
ATOM   2405 O OG   . SER A 1 158 ? 1.97363   34.39072 12.89156  1.000 22.66083  ? 158 SER A OG   1 
ATOM   2406 H H    . SER A 1 158 ? -0.71007  34.66997 14.57362  1.000 19.50983  ? 158 SER A H    1 
ATOM   2407 H HA   . SER A 1 158 ? -0.15311  35.33088 11.99099  1.000 18.80312  ? 158 SER A HA   1 
ATOM   2408 H HB2  . SER A 1 158 ? 0.61471   33.09226 13.48905  1.000 22.20335  ? 158 SER A HB2  1 
ATOM   2409 H HB3  . SER A 1 158 ? 0.80165   33.14329 11.91175  1.000 22.20335  ? 158 SER A HB3  1 
ATOM   2410 H HG   . SER A 1 158 ? 2.62064   33.85559 12.91627  1.000 27.19300  ? 158 SER A HG   1 
ATOM   2411 N N    . PHE A 1 159 ? -2.37827  34.55028 11.20419  1.000 16.12737  ? 159 PHE A N    1 
ATOM   2412 C CA   . PHE A 1 159 ? -3.56479  33.96038 10.61177  1.000 14.51203  ? 159 PHE A CA   1 
ATOM   2413 C C    . PHE A 1 159 ? -3.13398  32.93640 9.58376   1.000 14.39981  ? 159 PHE A C    1 
ATOM   2414 O O    . PHE A 1 159 ? -2.30867  33.22713 8.69611   1.000 15.89422  ? 159 PHE A O    1 
ATOM   2415 C CB   . PHE A 1 159 ? -4.41170  35.05246 9.92723   1.000 14.56374  ? 159 PHE A CB   1 
ATOM   2416 C CG   . PHE A 1 159 ? -5.00478  36.02048 10.88299  1.000 15.27538  ? 159 PHE A CG   1 
ATOM   2417 C CD1  . PHE A 1 159 ? -6.12452  35.70277 11.63912  1.000 16.67679  ? 159 PHE A CD1  1 
ATOM   2418 C CD2  . PHE A 1 159 ? -4.47063  37.30117 11.00376  1.000 16.41994  ? 159 PHE A CD2  1 
ATOM   2419 C CE1  . PHE A 1 159 ? -6.68198  36.63377 12.50213  1.000 19.21828  ? 159 PHE A CE1  1 
ATOM   2420 C CE2  . PHE A 1 159 ? -5.02654  38.25474 11.85282  1.000 18.47593  ? 159 PHE A CE2  1 
ATOM   2421 C CZ   . PHE A 1 159 ? -6.15136  37.91560 12.59034  1.000 16.27141  ? 159 PHE A CZ   1 
ATOM   2422 H H    . PHE A 1 159 ? -2.18764  35.32944 10.89409  1.000 19.35284  ? 159 PHE A H    1 
ATOM   2423 H HA   . PHE A 1 159 ? -4.10525  33.53276 11.29437  1.000 17.41444  ? 159 PHE A HA   1 
ATOM   2424 H HB2  . PHE A 1 159 ? -3.84764  35.54775 9.31289   1.000 17.47649  ? 159 PHE A HB2  1 
ATOM   2425 H HB3  . PHE A 1 159 ? -5.13767  34.62889 9.44302   1.000 17.47649  ? 159 PHE A HB3  1 
ATOM   2426 H HD1  . PHE A 1 159 ? -6.50459  34.85712 11.56616  1.000 20.01215  ? 159 PHE A HD1  1 
ATOM   2427 H HD2  . PHE A 1 159 ? -3.72035  37.52616 10.50241  1.000 19.70393  ? 159 PHE A HD2  1 
ATOM   2428 H HE1  . PHE A 1 159 ? -7.41472  36.39947 13.02472  1.000 23.06193  ? 159 PHE A HE1  1 
ATOM   2429 H HE2  . PHE A 1 159 ? -4.65092  39.10253 11.92402  1.000 22.17111  ? 159 PHE A HE2  1 
ATOM   2430 H HZ   . PHE A 1 159 ? -6.55100  38.54656 13.14449  1.000 19.52570  ? 159 PHE A HZ   1 
ATOM   2431 N N    . CYS A 1 160 ? -3.69408  31.75173 9.67405   1.000 14.23152  ? 160 CYS A N    1 
ATOM   2432 C CA   . CYS A 1 160 ? -3.36565  30.66253 8.76775   1.000 15.81229  ? 160 CYS A CA   1 
ATOM   2433 C C    . CYS A 1 160 ? -4.51421  30.04130 8.01641   1.000 14.01486  ? 160 CYS A C    1 
ATOM   2434 O O    . CYS A 1 160 ? -4.25181  29.30506 7.06778   1.000 16.69590  ? 160 CYS A O    1 
ATOM   2435 C CB   . CYS A 1 160 ? -2.59936  29.55256 9.49309   1.000 14.01920  ? 160 CYS A CB   1 
ATOM   2436 S SG   . CYS A 1 160 ? -3.44186  28.84968 10.91121  1.000 17.83993  ? 160 CYS A SG   1 
ATOM   2437 H H    . CYS A 1 160 ? -4.28302  31.54260 10.26482  1.000 17.07782  ? 160 CYS A H    1 
ATOM   2438 H HA   . CYS A 1 160 ? -2.78371  31.04706 8.09367   1.000 18.97475  ? 160 CYS A HA   1 
ATOM   2439 H HB2  . CYS A 1 160 ? -2.43646  28.83153 8.86501   1.000 16.82304  ? 160 CYS A HB2  1 
ATOM   2440 H HB3  . CYS A 1 160 ? -1.75652  29.91622 9.80657   1.000 16.82304  ? 160 CYS A HB3  1 
ATOM   2441 H HG   . CYS A 1 160 ? -4.59270  28.66140 10.62815  1.000 21.40791  ? 160 CYS A HG   1 
ATOM   2442 N N    . TYR A 1 161 ? -5.75465  30.27492 8.38461   1.000 13.58274  ? 161 TYR A N    1 
ATOM   2443 C CA   . TYR A 1 161 ? -6.89668  29.54182 7.84458   1.000 12.17237  ? 161 TYR A CA   1 
ATOM   2444 C C    . TYR A 1 161 ? -8.11762  30.43714 7.78630   1.000 13.81682  ? 161 TYR A C    1 
ATOM   2445 O O    . TYR A 1 161 ? -8.36099  31.23036 8.68694   1.000 13.75072  ? 161 TYR A O    1 
ATOM   2446 C CB   . TYR A 1 161 ? -7.22920  28.31001 8.66632   1.000 12.94725  ? 161 TYR A CB   1 
ATOM   2447 C CG   . TYR A 1 161 ? -8.40742  27.49169 8.20181   1.000 11.74099  ? 161 TYR A CG   1 
ATOM   2448 C CD1  . TYR A 1 161 ? -8.26010  26.50518 7.22873   1.000 12.12941  ? 161 TYR A CD1  1 
ATOM   2449 C CD2  . TYR A 1 161 ? -9.66821  27.61939 8.76495   1.000 15.23283  ? 161 TYR A CD2  1 
ATOM   2450 C CE1  . TYR A 1 161 ? -9.32165  25.75485 6.78367   1.000 13.45481  ? 161 TYR A CE1  1 
ATOM   2451 C CE2  . TYR A 1 161 ? -10.73178 26.84153 8.36433   1.000 13.51523  ? 161 TYR A CE2  1 
ATOM   2452 C CZ   . TYR A 1 161 ? -10.56012 25.91379 7.33297   1.000 13.11525  ? 161 TYR A CZ   1 
ATOM   2453 O OH   . TYR A 1 161 ? -11.59582 25.13098 6.89952   1.000 14.61926  ? 161 TYR A OH   1 
ATOM   2454 H H    . TYR A 1 161 ? -5.97710  30.87039 8.96386   1.000 16.29929  ? 161 TYR A H    1 
ATOM   2455 H HA   . TYR A 1 161 ? -6.67051  29.26890 6.94166   1.000 14.60684  ? 161 TYR A HA   1 
ATOM   2456 H HB2  . TYR A 1 161 ? -6.45561  27.72485 8.65899   1.000 15.53669  ? 161 TYR A HB2  1 
ATOM   2457 H HB3  . TYR A 1 161 ? -7.42074  28.59538 9.57339   1.000 15.53669  ? 161 TYR A HB3  1 
ATOM   2458 H HD1  . TYR A 1 161 ? -7.41662  26.34974 6.86918   1.000 14.55529  ? 161 TYR A HD1  1 
ATOM   2459 H HD2  . TYR A 1 161 ? -9.79983  28.25083 9.43493   1.000 18.27940  ? 161 TYR A HD2  1 
ATOM   2460 H HE1  . TYR A 1 161 ? -9.19487  25.13405 6.10290   1.000 16.14577  ? 161 TYR A HE1  1 
ATOM   2461 H HE2  . TYR A 1 161 ? -11.55977 26.93302 8.77779   1.000 16.21828  ? 161 TYR A HE2  1 
ATOM   2462 H HH   . TYR A 1 161 ? -11.31628 24.56654 6.34377   1.000 17.54311  ? 161 TYR A HH   1 
ATOM   2463 N N    . MET A 1 162 ? -8.85116  30.33563 6.69900   1.000 12.94899  ? 162 MET A N    1 
ATOM   2464 C CA   . MET A 1 162 ? -10.18613 30.92088 6.56768   1.000 11.07150  ? 162 MET A CA   1 
ATOM   2465 C C    . MET A 1 162 ? -11.12975 29.84364 6.06500   1.000 11.61664  ? 162 MET A C    1 
ATOM   2466 O O    . MET A 1 162 ? -10.82323 29.12724 5.10044   1.000 11.34059  ? 162 MET A O    1 
ATOM   2467 C CB   . MET A 1 162 ? -10.22272 32.12545 5.58659   1.000 14.20321  ? 162 MET A CB   1 
ATOM   2468 C CG   . MET A 1 162 ? -11.62203 32.69366 5.48803   1.000 16.80649  ? 162 MET A CG   1 
ATOM   2469 S SD   . MET A 1 162 ? -11.72034 34.37483 4.69908   1.000 21.06420  ? 162 MET A SD   1 
ATOM   2470 C CE   . MET A 1 162 ? -11.39929 35.44176 6.11570   1.000 20.99070  ? 162 MET A CE   1 
ATOM   2471 H H    . MET A 1 162 ? -8.59582  29.91840 5.99167   1.000 15.53879  ? 162 MET A H    1 
ATOM   2472 H HA   . MET A 1 162 ? -10.46236 31.24701 7.43844   1.000 13.28580  ? 162 MET A HA   1 
ATOM   2473 H HB2  . MET A 1 162 ? -9.62838  32.82183 5.90710   1.000 17.04385  ? 162 MET A HB2  1 
ATOM   2474 H HB3  . MET A 1 162 ? -9.94535  31.83264 4.70441   1.000 17.04385  ? 162 MET A HB3  1 
ATOM   2475 H HG2  . MET A 1 162 ? -12.16421 32.08952 4.95703   1.000 20.16778  ? 162 MET A HG2  1 
ATOM   2476 H HG3  . MET A 1 162 ? -11.98876 32.76892 6.38288   1.000 20.16778  ? 162 MET A HG3  1 
ATOM   2477 H HE1  . MET A 1 162 ? -11.40046 36.36609 5.82157   1.000 25.18884  ? 162 MET A HE1  1 
ATOM   2478 H HE2  . MET A 1 162 ? -12.09431 35.30460 6.77829   1.000 25.18884  ? 162 MET A HE2  1 
ATOM   2479 H HE3  . MET A 1 162 ? -10.53433 35.21544 6.49190   1.000 25.18884  ? 162 MET A HE3  1 
ATOM   2480 N N    . HIS A 1 163 ? -12.27050 29.70996 6.69660   1.000 13.73147  ? 163 HIS A N    1 
ATOM   2481 C CA   . HIS A 1 163 ? -13.18471 28.59792 6.43165   1.000 12.11913  ? 163 HIS A CA   1 
ATOM   2482 C C    . HIS A 1 163 ? -14.09021 28.81251 5.21939   1.000 12.97182  ? 163 HIS A C    1 
ATOM   2483 O O    . HIS A 1 163 ? -14.72538 29.84800 5.11647   1.000 13.94678  ? 163 HIS A O    1 
ATOM   2484 C CB   . HIS A 1 163 ? -14.10440 28.37915 7.63204   1.000 13.46842  ? 163 HIS A CB   1 
ATOM   2485 C CG   . HIS A 1 163 ? -14.92482 27.15432 7.49179   1.000 16.25381  ? 163 HIS A CG   1 
ATOM   2486 N ND1  . HIS A 1 163 ? -14.38174 25.93414 7.19845   1.000 14.05380  ? 163 HIS A ND1  1 
ATOM   2487 C CD2  . HIS A 1 163 ? -16.25892 26.97946 7.48191   1.000 13.63381  ? 163 HIS A CD2  1 
ATOM   2488 C CE1  . HIS A 1 163 ? -15.34797 25.05431 7.03167   1.000 15.56230  ? 163 HIS A CE1  1 
ATOM   2489 N NE2  . HIS A 1 163 ? -16.49585 25.67613 7.20833   1.000 15.58182  ? 163 HIS A NE2  1 
ATOM   2490 H H    . HIS A 1 163 ? -12.55537 30.25474 7.29799   1.000 16.47776  ? 163 HIS A H    1 
ATOM   2491 H HA   . HIS A 1 163 ? -12.62040 27.82933 6.25355   1.000 14.54296  ? 163 HIS A HA   1 
ATOM   2492 H HB2  . HIS A 1 163 ? -13.56547 28.29239 8.43386   1.000 16.16211  ? 163 HIS A HB2  1 
ATOM   2493 H HB3  . HIS A 1 163 ? -14.70386 29.13715 7.71563   1.000 16.16211  ? 163 HIS A HB3  1 
ATOM   2494 H HD2  . HIS A 1 163 ? -16.90072 27.63483 7.63515   1.000 16.36057  ? 163 HIS A HD2  1 
ATOM   2495 H HE1  . HIS A 1 163 ? -15.23906 24.15395 6.82576   1.000 18.67476  ? 163 HIS A HE1  1 
ATOM   2496 H HE2  . HIS A 1 163 ? -17.27292 25.31116 7.15771   1.000 18.69819  ? 163 HIS A HE2  1 
ATOM   2497 N N    . HIS A 1 164 ? -14.15963 27.80520 4.35835   1.000 14.22654  ? 164 HIS A N    1 
ATOM   2498 C CA   . HIS A 1 164 ? -15.00396 27.84611 3.16152   1.000 12.95206  ? 164 HIS A CA   1 
ATOM   2499 C C    . HIS A 1 164 ? -16.02468 26.73232 3.02249   1.000 14.54979  ? 164 HIS A C    1 
ATOM   2500 O O    . HIS A 1 164 ? -17.09088 26.99764 2.40817   1.000 15.41995  ? 164 HIS A O    1 
ATOM   2501 C CB   . HIS A 1 164 ? -14.13072 27.81207 1.87200   1.000 12.21217  ? 164 HIS A CB   1 
ATOM   2502 C CG   . HIS A 1 164 ? -13.31956 29.04662 1.67277   1.000 15.86484  ? 164 HIS A CG   1 
ATOM   2503 N ND1  . HIS A 1 164 ? -13.46843 29.88593 0.59154   1.000 14.78800  ? 164 HIS A ND1  1 
ATOM   2504 C CD2  . HIS A 1 164 ? -12.25663 29.52386 2.36735   1.000 13.69855  ? 164 HIS A CD2  1 
ATOM   2505 C CE1  . HIS A 1 164 ? -12.59965 30.87089 0.67786   1.000 15.18530  ? 164 HIS A CE1  1 
ATOM   2506 N NE2  . HIS A 1 164 ? -11.83728 30.66980 1.74251   1.000 15.16001  ? 164 HIS A NE2  1 
ATOM   2507 H H    . HIS A 1 164 ? -13.72008 27.07092 4.44338   1.000 17.07185  ? 164 HIS A H    1 
ATOM   2508 H HA   . HIS A 1 164 ? -15.49240 28.68270 3.21091   1.000 15.54247  ? 164 HIS A HA   1 
ATOM   2509 H HB2  . HIS A 1 164 ? -13.51994 27.06053 1.92717   1.000 14.65460  ? 164 HIS A HB2  1 
ATOM   2510 H HB3  . HIS A 1 164 ? -14.71247 27.71099 1.10243   1.000 14.65460  ? 164 HIS A HB3  1 
ATOM   2511 H HD1  . HIS A 1 164 ? -14.04056 29.78260 -0.04217  1.000 17.74559  ? 164 HIS A HD1  1 
ATOM   2512 H HD2  . HIS A 1 164 ? -11.88104 29.14329 3.12827   1.000 16.43826  ? 164 HIS A HD2  1 
ATOM   2513 H HE1  . HIS A 1 164 ? -12.53223 31.58816 0.08975   1.000 18.22236  ? 164 HIS A HE1  1 
ATOM   2514 N N    . MET A 1 165 ? -15.77379 25.50569 3.47678   1.000 15.19195  ? 165 MET A N    1 
ATOM   2515 C CA   . MET A 1 165 ? -16.72612 24.46489 3.12629   1.000 18.30423  ? 165 MET A CA   1 
ATOM   2516 C C    . MET A 1 165 ? -16.59371 23.21085 3.97337   1.000 18.21354  ? 165 MET A C    1 
ATOM   2517 O O    . MET A 1 165 ? -15.59417 22.98232 4.67181   1.000 16.72242  ? 165 MET A O    1 
ATOM   2518 C CB   . MET A 1 165 ? -16.56325 24.06824 1.65507   1.000 22.98563  ? 165 MET A CB   1 
ATOM   2519 C CG   . MET A 1 165 ? -15.18817 23.64909 1.38026   1.000 22.24378  ? 165 MET A CG   1 
ATOM   2520 S SD   . MET A 1 165 ? -14.90102 23.49978 -0.45386  1.000 34.39709  ? 165 MET A SD   1 
ATOM   2521 C CE   . MET A 1 165 ? -14.65792 21.76452 -0.39559  1.000 22.81060  ? 165 MET A CE   1 
ATOM   2522 H H    . MET A 1 165 ? -15.10127 25.27026 3.95833   1.000 18.23034  ? 165 MET A H    1 
ATOM   2523 H HA   . MET A 1 165 ? -17.59868 24.84504 3.31349   1.000 21.96508  ? 165 MET A HA   1 
ATOM   2524 H HB2  . MET A 1 165 ? -17.15785 23.32935 1.45163   1.000 27.58276  ? 165 MET A HB2  1 
ATOM   2525 H HB3  . MET A 1 165 ? -16.77320 24.82826 1.09010   1.000 27.58276  ? 165 MET A HB3  1 
ATOM   2526 H HG2  . MET A 1 165 ? -14.57130 24.30728 1.73686   1.000 26.69254  ? 165 MET A HG2  1 
ATOM   2527 H HG3  . MET A 1 165 ? -15.02472 22.78510 1.78978   1.000 26.69254  ? 165 MET A HG3  1 
ATOM   2528 H HE1  . MET A 1 165 ? -13.96900 21.56389 0.25712   1.000 27.37272  ? 165 MET A HE1  1 
ATOM   2529 H HE2  . MET A 1 165 ? -15.49041 21.33742 -0.13977  1.000 27.37272  ? 165 MET A HE2  1 
ATOM   2530 H HE3  . MET A 1 165 ? -14.38298 21.45453 -1.27264  1.000 27.37272  ? 165 MET A HE3  1 
ATOM   2531 N N    . GLU A 1 166 ? -17.62542 22.37434 3.86440   1.000 15.33139  ? 166 GLU A N    1 
ATOM   2532 C CA   . GLU A 1 166 ? -17.64149 21.07289 4.51925   1.000 15.28200  ? 166 GLU A CA   1 
ATOM   2533 C C    . GLU A 1 166 ? -17.70799 19.98152 3.45902   1.000 20.43058  ? 166 GLU A C    1 
ATOM   2534 O O    . GLU A 1 166 ? -18.54226 20.05307 2.54111   1.000 20.61917  ? 166 GLU A O    1 
ATOM   2535 C CB   . GLU A 1 166 ? -18.86690 20.95309 5.43750   1.000 17.62000  ? 166 GLU A CB   1 
ATOM   2536 C CG   . GLU A 1 166 ? -18.97411 19.58658 6.12907   1.000 20.72094  ? 166 GLU A CG   1 
ATOM   2537 C CD   . GLU A 1 166 ? -19.98704 19.56909 7.25899   1.000 26.53891  ? 166 GLU A CD   1 
ATOM   2538 O OE1  . GLU A 1 166 ? -19.96090 20.47996 8.11688   1.000 23.71180  ? 166 GLU A OE1  1 
ATOM   2539 O OE2  . GLU A 1 166 ? -20.81356 18.62559 7.27909   1.000 27.31831  ? 166 GLU A OE2  1 
ATOM   2540 H H    . GLU A 1 166 ? -18.33551 22.54364 3.40974   1.000 18.39767  ? 166 GLU A H    1 
ATOM   2541 H HA   . GLU A 1 166 ? -16.83127 20.95930 5.04035   1.000 18.33840  ? 166 GLU A HA   1 
ATOM   2542 H HB2  . GLU A 1 166 ? -18.80997 21.63287 6.12712   1.000 21.14400  ? 166 GLU A HB2  1 
ATOM   2543 H HB3  . GLU A 1 166 ? -19.66942 21.08357 4.90850   1.000 21.14400  ? 166 GLU A HB3  1 
ATOM   2544 H HG2  . GLU A 1 166 ? -19.24483 18.92322 5.47519   1.000 24.86513  ? 166 GLU A HG2  1 
ATOM   2545 H HG3  . GLU A 1 166 ? -18.10892 19.35282 6.50016   1.000 24.86513  ? 166 GLU A HG3  1 
ATOM   2546 N N    . LEU A 1 167 ? -16.86527 18.98064 3.58321   1.000 17.98535  ? 167 LEU A N    1 
ATOM   2547 C CA   . LEU A 1 167 ? -16.81414 17.85042 2.66240   1.000 16.16377  ? 167 LEU A CA   1 
ATOM   2548 C C    . LEU A 1 167 ? -17.79129 16.77624 3.09144   1.000 21.07295  ? 167 LEU A C    1 
ATOM   2549 O O    . LEU A 1 167 ? -18.34392 16.81362 4.18907   1.000 21.77362  ? 167 LEU A O    1 
ATOM   2550 C CB   . LEU A 1 167 ? -15.39364 17.33166 2.59980   1.000 18.83705  ? 167 LEU A CB   1 
ATOM   2551 C CG   . LEU A 1 167 ? -14.41628 18.36809 2.08223   1.000 21.53625  ? 167 LEU A CG   1 
ATOM   2552 C CD1  . LEU A 1 167 ? -12.99614 17.94059 2.35047   1.000 25.20734  ? 167 LEU A CD1  1 
ATOM   2553 C CD2  . LEU A 1 167 ? -14.63155 18.59495 0.57276   1.000 26.94988  ? 167 LEU A CD2  1 
ATOM   2554 H H    . LEU A 1 167 ? -16.28607 18.92383 4.21637   1.000 21.58242  ? 167 LEU A H    1 
ATOM   2555 H HA   . LEU A 1 167 ? -17.07044 18.13128 1.77003   1.000 19.39652  ? 167 LEU A HA   1 
ATOM   2556 H HB2  . LEU A 1 167 ? -15.11323 17.07143 3.49118   1.000 22.60446  ? 167 LEU A HB2  1 
ATOM   2557 H HB3  . LEU A 1 167 ? -15.36345 16.56554 2.00562   1.000 22.60446  ? 167 LEU A HB3  1 
ATOM   2558 H HG   . LEU A 1 167 ? -14.56960 19.20679 2.54482   1.000 25.84350  ? 167 LEU A HG   1 
ATOM   2559 H HD11 . LEU A 1 167 ? -12.39636 18.65817 2.09307   1.000 30.24881  ? 167 LEU A HD11 1 
ATOM   2560 H HD12 . LEU A 1 167 ? -12.89705 17.74993 3.29637   1.000 30.24881  ? 167 LEU A HD12 1 
ATOM   2561 H HD13 . LEU A 1 167 ? -12.80230 17.14495 1.83058   1.000 30.24881  ? 167 LEU A HD13 1 
ATOM   2562 H HD21 . LEU A 1 167 ? -13.92900 19.17337 0.23698   1.000 32.33985  ? 167 LEU A HD21 1 
ATOM   2563 H HD22 . LEU A 1 167 ? -14.60126 17.73906 0.11730   1.000 32.33985  ? 167 LEU A HD22 1 
ATOM   2564 H HD23 . LEU A 1 167 ? -15.49670 19.01183 0.43628   1.000 32.33985  ? 167 LEU A HD23 1 
ATOM   2565 N N    . PRO A 1 168 ? -18.05562 15.78702 2.21021   1.000 23.12924  ? 168 PRO A N    1 
ATOM   2566 C CA   . PRO A 1 168 ? -19.12998 14.82558 2.50220   1.000 28.41969  ? 168 PRO A CA   1 
ATOM   2567 C C    . PRO A 1 168 ? -18.90322 13.99844 3.74569   1.000 28.75698  ? 168 PRO A C    1 
ATOM   2568 O O    . PRO A 1 168 ? -19.87958 13.54182 4.35235   1.000 30.74538  ? 168 PRO A O    1 
ATOM   2569 C CB   . PRO A 1 168 ? -19.16565 13.95226 1.24346   1.000 26.86129  ? 168 PRO A CB   1 
ATOM   2570 C CG   . PRO A 1 168 ? -18.63427 14.85348 0.14568   1.000 29.79911  ? 168 PRO A CG   1 
ATOM   2571 C CD   . PRO A 1 168 ? -17.56567 15.68060 0.82508   1.000 25.10634  ? 168 PRO A CD   1 
ATOM   2572 H HA   . PRO A 1 168 ? -19.97019 15.30148 2.59425   1.000 34.10363  ? 168 PRO A HA   1 
ATOM   2573 H HB2  . PRO A 1 168 ? -18.59860 13.17425 1.36204   1.000 32.23355  ? 168 PRO A HB2  1 
ATOM   2574 H HB3  . PRO A 1 168 ? -20.07601 13.67399 1.05718   1.000 32.23355  ? 168 PRO A HB3  1 
ATOM   2575 H HG2  . PRO A 1 168 ? -18.25886 14.31927 -0.57166  1.000 35.75893  ? 168 PRO A HG2  1 
ATOM   2576 H HG3  . PRO A 1 168 ? -19.34599 15.41627 -0.19730  1.000 35.75893  ? 168 PRO A HG3  1 
ATOM   2577 H HD2  . PRO A 1 168 ? -16.70769 15.22907 0.79538   1.000 30.12761  ? 168 PRO A HD2  1 
ATOM   2578 H HD3  . PRO A 1 168 ? -17.49379 16.55686 0.41531   1.000 30.12761  ? 168 PRO A HD3  1 
ATOM   2579 N N    . THR A 1 169 ? -17.65179 13.79132 4.15871   1.000 27.97100  ? 169 THR A N    1 
ATOM   2580 C CA   . THR A 1 169 ? -17.38502 13.02702 5.36967   1.000 26.26134  ? 169 THR A CA   1 
ATOM   2581 C C    . THR A 1 169 ? -17.53910 13.84764 6.64443   1.000 24.84365  ? 169 THR A C    1 
ATOM   2582 O O    . THR A 1 169 ? -17.30654 13.32142 7.72261   1.000 27.35556  ? 169 THR A O    1 
ATOM   2583 C CB   . THR A 1 169 ? -15.96662 12.41841 5.31844   1.000 28.87813  ? 169 THR A CB   1 
ATOM   2584 O OG1  . THR A 1 169 ? -15.01433 13.43682 4.95270   1.000 27.11086  ? 169 THR A OG1  1 
ATOM   2585 C CG2  . THR A 1 169 ? -15.91717 11.27707 4.27974   1.000 31.28086  ? 169 THR A CG2  1 
ATOM   2586 H H    . THR A 1 169 ? -16.94944 14.08179 3.75632   1.000 33.56520  ? 169 THR A H    1 
ATOM   2587 H HA   . THR A 1 169 ? -18.02160 12.29623 5.40983   1.000 31.51361  ? 169 THR A HA   1 
ATOM   2588 H HB   . THR A 1 169 ? -15.73308 12.05914 6.18866   1.000 34.65376  ? 169 THR A HB   1 
ATOM   2589 H HG1  . THR A 1 169 ? -14.99717 14.03801 5.53910   1.000 32.53303  ? 169 THR A HG1  1 
ATOM   2590 H HG21 . THR A 1 169 ? -15.05123 10.84084 4.30715   1.000 37.53703  ? 169 THR A HG21 1 
ATOM   2591 H HG22 . THR A 1 169 ? -16.60590 10.62208 4.47351   1.000 37.53703  ? 169 THR A HG22 1 
ATOM   2592 H HG23 . THR A 1 169 ? -16.06251 11.63258 3.38902   1.000 37.53703  ? 169 THR A HG23 1 
ATOM   2593 N N    . GLY A 1 170 ? -17.89917 15.11727 6.54032   1.000 21.06404  ? 170 GLY A N    1 
ATOM   2594 C CA   . GLY A 1 170 ? -18.09875 15.94073 7.70606   1.000 25.34699  ? 170 GLY A CA   1 
ATOM   2595 C C    . GLY A 1 170 ? -16.85880 16.70598 8.14578   1.000 21.89097  ? 170 GLY A C    1 
ATOM   2596 O O    . GLY A 1 170 ? -16.91910 17.39722 9.15601   1.000 25.49331  ? 170 GLY A O    1 
ATOM   2597 H H    . GLY A 1 170 ? -18.03409 15.52387 5.79461   1.000 25.27685  ? 170 GLY A H    1 
ATOM   2598 H HA2  . GLY A 1 170 ? -18.79776 16.58640 7.51796   1.000 30.41639  ? 170 GLY A HA2  1 
ATOM   2599 H HA3  . GLY A 1 170 ? -18.37971 15.37705 8.44378   1.000 30.41639  ? 170 GLY A HA3  1 
ATOM   2600 N N    . VAL A 1 171 ? -15.76607 16.60827 7.40676   1.000 20.09490  ? 171 VAL A N    1 
ATOM   2601 C CA   . VAL A 1 171 ? -14.55460 17.36155 7.68663   1.000 16.08180  ? 171 VAL A CA   1 
ATOM   2602 C C    . VAL A 1 171 ? -14.58718 18.65471 6.87433   1.000 17.19199  ? 171 VAL A C    1 
ATOM   2603 O O    . VAL A 1 171 ? -15.45203 18.83975 6.00857   1.000 17.00311  ? 171 VAL A O    1 
ATOM   2604 C CB   . VAL A 1 171 ? -13.27195 16.56974 7.39816   1.000 17.33430  ? 171 VAL A CB   1 
ATOM   2605 C CG1  . VAL A 1 171 ? -13.23234 15.26641 8.21926   1.000 22.56857  ? 171 VAL A CG1  1 
ATOM   2606 C CG2  . VAL A 1 171 ? -13.11718 16.26850 5.89787   1.000 18.15681  ? 171 VAL A CG2  1 
ATOM   2607 H H    . VAL A 1 171 ? -15.69829 16.09808 6.71777   1.000 24.11388  ? 171 VAL A H    1 
ATOM   2608 H HA   . VAL A 1 171 ? -14.54593 17.57254 8.63336   1.000 19.29816  ? 171 VAL A HA   1 
ATOM   2609 H HB   . VAL A 1 171 ? -12.51880 17.11972 7.66497   1.000 20.80116  ? 171 VAL A HB   1 
ATOM   2610 H HG11 . VAL A 1 171 ? -12.37495 14.83357 8.08350   1.000 27.08228  ? 171 VAL A HG11 1 
ATOM   2611 H HG12 . VAL A 1 171 ? -13.34966 15.48086 9.15796   1.000 27.08228  ? 171 VAL A HG12 1 
ATOM   2612 H HG13 . VAL A 1 171 ? -13.94804 14.68349 7.92117   1.000 27.08228  ? 171 VAL A HG13 1 
ATOM   2613 H HG21 . VAL A 1 171 ? -12.40475 15.62129 5.77756   1.000 21.78818  ? 171 VAL A HG21 1 
ATOM   2614 H HG22 . VAL A 1 171 ? -13.95206 15.90797 5.56038   1.000 21.78818  ? 171 VAL A HG22 1 
ATOM   2615 H HG23 . VAL A 1 171 ? -12.89939 17.09068 5.43150   1.000 21.78818  ? 171 VAL A HG23 1 
ATOM   2616 N N    . HIS A 1 172 ? -13.61784 19.52184 7.09970   1.000 14.96428  ? 172 HIS A N    1 
ATOM   2617 C CA   . HIS A 1 172 ? -13.72143 20.92088 6.68020   1.000 15.65438  ? 172 HIS A CA   1 
ATOM   2618 C C    . HIS A 1 172 ? -12.52296 21.32470 5.85260   1.000 16.43331  ? 172 HIS A C    1 
ATOM   2619 O O    . HIS A 1 172 ? -11.41750 20.79377 6.01801   1.000 14.33703  ? 172 HIS A O    1 
ATOM   2620 C CB   . HIS A 1 172 ? -13.88887 21.79815 7.93424   1.000 12.91362  ? 172 HIS A CB   1 
ATOM   2621 C CG   . HIS A 1 172 ? -15.13219 21.45245 8.67434   1.000 12.91914  ? 172 HIS A CG   1 
ATOM   2622 N ND1  . HIS A 1 172 ? -15.13762 20.75079 9.87740   1.000 15.43129  ? 172 HIS A ND1  1 
ATOM   2623 C CD2  . HIS A 1 172 ? -16.42499 21.66451 8.34893   1.000 16.97745  ? 172 HIS A CD2  1 
ATOM   2624 C CE1  . HIS A 1 172 ? -16.39008 20.55957 10.24933  1.000 18.32719  ? 172 HIS A CE1  1 
ATOM   2625 N NE2  . HIS A 1 172 ? -17.18315 21.10300 9.34696   1.000 16.55405  ? 172 HIS A NE2  1 
ATOM   2626 H H    . HIS A 1 172 ? -12.88006 19.32899 7.49730   1.000 17.95713  ? 172 HIS A H    1 
ATOM   2627 H HA   . HIS A 1 172 ? -14.48080 21.06185 6.09336   1.000 18.78526  ? 172 HIS A HA   1 
ATOM   2628 H HB2  . HIS A 1 172 ? -13.13225 21.66105 8.52554   1.000 15.49634  ? 172 HIS A HB2  1 
ATOM   2629 H HB3  . HIS A 1 172 ? -13.93879 22.73012 7.66997   1.000 15.49634  ? 172 HIS A HB3  1 
ATOM   2630 H HD2  . HIS A 1 172 ? -16.74143 22.10598 7.59403   1.000 20.37295  ? 172 HIS A HD2  1 
ATOM   2631 H HE1  . HIS A 1 172 ? -16.66645 20.11604 11.01862  1.000 21.99263  ? 172 HIS A HE1  1 
ATOM   2632 H HE2  . HIS A 1 172 ? -18.04257 21.10546 9.37849   1.000 19.86486  ? 172 HIS A HE2  1 
ATOM   2633 N N    . ALA A 1 173 ? -12.74688 22.29017 4.97260   1.000 15.19637  ? 173 ALA A N    1 
ATOM   2634 C CA   . ALA A 1 173 ? -11.72944 22.71930 4.01836   1.000 13.50230  ? 173 ALA A CA   1 
ATOM   2635 C C    . ALA A 1 173 ? -11.79730 24.24390 3.90153   1.000 13.17681  ? 173 ALA A C    1 
ATOM   2636 O O    . ALA A 1 173 ? -12.84793 24.86544 4.02234   1.000 14.61622  ? 173 ALA A O    1 
ATOM   2637 C CB   . ALA A 1 173 ? -11.89488 22.06644 2.64063   1.000 16.04579  ? 173 ALA A CB   1 
ATOM   2638 H H    . ALA A 1 173 ? -13.48930 22.71907 4.90583   1.000 18.23565  ? 173 ALA A H    1 
ATOM   2639 H HA   . ALA A 1 173 ? -10.85064 22.46608 4.34162   1.000 16.20276  ? 173 ALA A HA   1 
ATOM   2640 H HB1  . ALA A 1 173 ? -11.75358 21.11052 2.72512   1.000 19.25495  ? 173 ALA A HB1  1 
ATOM   2641 H HB2  . ALA A 1 173 ? -12.79154 22.24070 2.31421   1.000 19.25495  ? 173 ALA A HB2  1 
ATOM   2642 H HB3  . ALA A 1 173 ? -11.24174 22.44479 2.03140   1.000 19.25495  ? 173 ALA A HB3  1 
ATOM   2643 N N    . GLY A 1 174 ? -10.65265 24.83883 3.60690   1.000 13.48938  ? 174 GLY A N    1 
ATOM   2644 C CA   . GLY A 1 174 ? -10.55536 26.27318 3.51685   1.000 12.46643  ? 174 GLY A CA   1 
ATOM   2645 C C    . GLY A 1 174 ? -9.22492  26.68783 2.96062   1.000 13.97099  ? 174 GLY A C    1 
ATOM   2646 O O    . GLY A 1 174 ? -8.50218  25.88186 2.38133   1.000 13.86270  ? 174 GLY A O    1 
ATOM   2647 H H    . GLY A 1 174 ? -9.91358  24.42650 3.45409   1.000 16.18726  ? 174 GLY A H    1 
ATOM   2648 H HA2  . GLY A 1 174 ? -11.25470 26.61241 2.93655   1.000 14.95971  ? 174 GLY A HA2  1 
ATOM   2649 H HA3  . GLY A 1 174 ? -10.65949 26.66383 4.39858   1.000 14.95971  ? 174 GLY A HA3  1 
ATOM   2650 N N    . THR A 1 175 ? -8.96837  27.99531 3.06765   1.000 12.31038  ? 175 THR A N    1 
ATOM   2651 C CA   . THR A 1 175 ? -7.81302  28.57256 2.41168   1.000 13.26705  ? 175 THR A CA   1 
ATOM   2652 C C    . THR A 1 175 ? -6.88708  29.22086 3.42105   1.000 12.27533  ? 175 THR A C    1 
ATOM   2653 O O    . THR A 1 175 ? -7.24649  29.42739 4.58616   1.000 13.83138  ? 175 THR A O    1 
ATOM   2654 C CB   . THR A 1 175 ? -8.23525  29.68016 1.42659   1.000 16.03198  ? 175 THR A CB   1 
ATOM   2655 O OG1  . THR A 1 175 ? -8.80680  30.80062 2.15125   1.000 14.65988  ? 175 THR A OG1  1 
ATOM   2656 C CG2  . THR A 1 175 ? -9.21467  29.18424 0.38836   1.000 12.45246  ? 175 THR A CG2  1 
ATOM   2657 H H    . THR A 1 175 ? -9.44906  28.55337 3.51161   1.000 14.77246  ? 175 THR A H    1 
ATOM   2658 H HA   . THR A 1 175 ? -7.35147  27.85369 1.95222   1.000 15.92046  ? 175 THR A HA   1 
ATOM   2659 H HB   . THR A 1 175 ? -7.44470  29.97556 0.94839   1.000 19.23838  ? 175 THR A HB   1 
ATOM   2660 H HG1  . THR A 1 175 ? -9.59431  30.62166 2.38232   1.000 17.59185  ? 175 THR A HG1  1 
ATOM   2661 H HG21 . THR A 1 175 ? -8.77822  28.55265 -0.20452  1.000 14.94295  ? 175 THR A HG21 1 
ATOM   2662 H HG22 . THR A 1 175 ? -9.96278  28.74418 0.82146   1.000 14.94295  ? 175 THR A HG22 1 
ATOM   2663 H HG23 . THR A 1 175 ? -9.54815  29.92924 -0.13574  1.000 14.94295  ? 175 THR A HG23 1 
ATOM   2664 N N    . ASP A 1 176 ? -5.65976  29.53261 2.98748   1.000 14.15135  ? 176 ASP A N    1 
ATOM   2665 C CA   . ASP A 1 176 ? -4.85960  30.52676 3.70453   1.000 14.55657  ? 176 ASP A CA   1 
ATOM   2666 C C    . ASP A 1 176 ? -5.47202  31.92162 3.48117   1.000 13.41582  ? 176 ASP A C    1 
ATOM   2667 O O    . ASP A 1 176 ? -6.50650  32.08373 2.77371   1.000 13.96367  ? 176 ASP A O    1 
ATOM   2668 C CB   . ASP A 1 176 ? -3.38088  30.33537 3.36848   1.000 14.05958  ? 176 ASP A CB   1 
ATOM   2669 C CG   . ASP A 1 176 ? -3.02911  30.69371 1.94473   1.000 18.39822  ? 176 ASP A CG   1 
ATOM   2670 O OD1  . ASP A 1 176 ? -3.77837  31.44618 1.29956   1.000 15.77007  ? 176 ASP A OD1  1 
ATOM   2671 O OD2  . ASP A 1 176 ? -1.95701  30.19834 1.46507   1.000 20.76917  ? 176 ASP A OD2  1 
ATOM   2672 H H    . ASP A 1 176 ? -5.27865  29.18967 2.29701   1.000 16.98161  ? 176 ASP A H    1 
ATOM   2673 H HA   . ASP A 1 176 ? -4.88749  30.41101 4.66720   1.000 17.46788  ? 176 ASP A HA   1 
ATOM   2674 H HB2  . ASP A 1 176 ? -2.85203  30.89911 3.95450   1.000 16.87150  ? 176 ASP A HB2  1 
ATOM   2675 H HB3  . ASP A 1 176 ? -3.14771  29.40378 3.50509   1.000 16.87150  ? 176 ASP A HB3  1 
ATOM   2676 N N    . LEU A 1 177 ? -4.88189  32.94057 4.12544   1.000 15.20353  ? 177 LEU A N    1 
ATOM   2677 C CA   . LEU A 1 177 ? -5.44340  34.27683 4.03936   1.000 16.08606  ? 177 LEU A CA   1 
ATOM   2678 C C    . LEU A 1 177 ? -5.07483  34.98958 2.75353   1.000 18.32596  ? 177 LEU A C    1 
ATOM   2679 O O    . LEU A 1 177 ? -5.53472  36.11319 2.53029   1.000 20.65191  ? 177 LEU A O    1 
ATOM   2680 C CB   . LEU A 1 177 ? -5.07453  35.13384 5.24337   1.000 15.58416  ? 177 LEU A CB   1 
ATOM   2681 C CG   . LEU A 1 177 ? -6.09249  35.11761 6.39721   1.000 16.81845  ? 177 LEU A CG   1 
ATOM   2682 C CD1  . LEU A 1 177 ? -7.44150  35.70841 6.01816   1.000 19.56378  ? 177 LEU A CD1  1 
ATOM   2683 C CD2  . LEU A 1 177 ? -6.24900  33.66364 6.91669   1.000 19.08703  ? 177 LEU A CD2  1 
ATOM   2684 H H    . LEU A 1 177 ? -4.17148  32.87447 4.60559   1.000 18.24423  ? 177 LEU A H    1 
ATOM   2685 H HA   . LEU A 1 177 ? -6.40880  34.18653 4.06681   1.000 19.30327  ? 177 LEU A HA   1 
ATOM   2686 H HB2  . LEU A 1 177 ? -4.22933  34.81556 5.59726   1.000 18.70099  ? 177 LEU A HB2  1 
ATOM   2687 H HB3  . LEU A 1 177 ? -4.98523  36.05338 4.94778   1.000 18.70099  ? 177 LEU A HB3  1 
ATOM   2688 H HG   . LEU A 1 177 ? -5.75474  35.68574 7.10718   1.000 20.18214  ? 177 LEU A HG   1 
ATOM   2689 H HD11 . LEU A 1 177 ? -7.82572  36.14281 6.79570   1.000 23.47654  ? 177 LEU A HD11 1 
ATOM   2690 H HD12 . LEU A 1 177 ? -7.31422  36.35553 5.30686   1.000 23.47654  ? 177 LEU A HD12 1 
ATOM   2691 H HD13 . LEU A 1 177 ? -8.02498  34.99496 5.71577   1.000 23.47654  ? 177 LEU A HD13 1 
ATOM   2692 H HD21 . LEU A 1 177 ? -6.82799  33.66695 7.69493   1.000 22.90444  ? 177 LEU A HD21 1 
ATOM   2693 H HD22 . LEU A 1 177 ? -6.63969  33.11830 6.21607   1.000 22.90444  ? 177 LEU A HD22 1 
ATOM   2694 H HD23 . LEU A 1 177 ? -5.37488  33.31804 7.15620   1.000 22.90444  ? 177 LEU A HD23 1 
ATOM   2695 N N    . GLU A 1 178 ? -4.21493  34.38219 1.94643   1.000 14.83321  ? 178 GLU A N    1 
ATOM   2696 C CA   . GLU A 1 178 ? -4.04876  34.86091 0.57755   1.000 17.68541  ? 178 GLU A CA   1 
ATOM   2697 C C    . GLU A 1 178 ? -5.05238  34.24290 -0.36358  1.000 16.39039  ? 178 GLU A C    1 
ATOM   2698 O O    . GLU A 1 178 ? -4.98260  34.49494 -1.56627  1.000 16.77744  ? 178 GLU A O    1 
ATOM   2699 C CB   . GLU A 1 178 ? -2.63040  34.56977 0.09738   1.000 18.57293  ? 178 GLU A CB   1 
ATOM   2700 C CG   . GLU A 1 178 ? -1.53154  35.12255 1.02672   1.000 25.11764  ? 178 GLU A CG   1 
ATOM   2701 C CD   . GLU A 1 178 ? -1.40173  36.61643 0.95646   1.000 23.67954  ? 178 GLU A CD   1 
ATOM   2702 O OE1  . GLU A 1 178 ? -2.17469  37.27996 0.27172   1.000 34.81705  ? 178 GLU A OE1  1 
ATOM   2703 O OE2  . GLU A 1 178 ? -0.46115  37.13824 1.64395   1.000 58.16518  ? 178 GLU A OE2  1 
ATOM   2704 H H    . GLU A 1 178 ? -3.72748  33.70720 2.16176   1.000 17.79985  ? 178 GLU A H    1 
ATOM   2705 H HA   . GLU A 1 178 ? -4.17110  35.82286 0.55336   1.000 21.22250  ? 178 GLU A HA   1 
ATOM   2706 H HB2  . GLU A 1 178 ? -2.51249  33.60873 0.03909   1.000 22.28751  ? 178 GLU A HB2  1 
ATOM   2707 H HB3  . GLU A 1 178 ? -2.50870  34.97256 -0.77661  1.000 22.28751  ? 178 GLU A HB3  1 
ATOM   2708 H HG2  . GLU A 1 178 ? -1.74358  34.88356 1.94259   1.000 30.14117  ? 178 GLU A HG2  1 
ATOM   2709 H HG3  . GLU A 1 178 ? -0.67919  34.73600 0.77182   1.000 30.14117  ? 178 GLU A HG3  1 
ATOM   2710 N N    . GLY A 1 179 ? -5.95825  33.40988 0.12241   1.000 13.33489  ? 179 GLY A N    1 
ATOM   2711 C CA   . GLY A 1 179 ? -7.02360  32.82649 -0.62633  1.000 14.85649  ? 179 GLY A CA   1 
ATOM   2712 C C    . GLY A 1 179 ? -6.69699  31.55170 -1.39095  1.000 14.25661  ? 179 GLY A C    1 
ATOM   2713 O O    . GLY A 1 179 ? -7.49590  31.13393 -2.26864  1.000 15.36640  ? 179 GLY A O    1 
ATOM   2714 H H    . GLY A 1 179 ? -5.96728  33.15638 0.94415   1.000 16.00187  ? 179 GLY A H    1 
ATOM   2715 H HA2  . GLY A 1 179 ? -7.74720  32.61902 -0.01456  1.000 17.82778  ? 179 GLY A HA2  1 
ATOM   2716 H HA3  . GLY A 1 179 ? -7.33411  33.47957 -1.27284  1.000 17.82778  ? 179 GLY A HA3  1 
ATOM   2717 N N    . ASN A 1 180 ? -5.56002  30.90839 -1.06523  1.000 13.10165  ? 180 ASN A N    1 
ATOM   2718 C CA   . ASN A 1 180 ? -5.17689  29.66924 -1.69220  1.000 13.42395  ? 180 ASN A CA   1 
ATOM   2719 C C    . ASN A 1 180 ? -5.61309  28.47365 -0.87597  1.000 12.50229  ? 180 ASN A C    1 
ATOM   2720 O O    . ASN A 1 180 ? -5.26173  28.36756 0.29875   1.000 11.06915  ? 180 ASN A O    1 
ATOM   2721 C CB   . ASN A 1 180 ? -3.65010  29.65159 -1.88927  1.000 13.92305  ? 180 ASN A CB   1 
ATOM   2722 C CG   . ASN A 1 180 ? -3.14663  30.86196 -2.67834  1.000 16.72088  ? 180 ASN A CG   1 
ATOM   2723 O OD1  . ASN A 1 180 ? -2.40693  31.71243 -2.16416  1.000 23.51616  ? 180 ASN A OD1  1 
ATOM   2724 N ND2  . ASN A 1 180 ? -3.53831  30.90880 -3.90336  1.000 15.76184  ? 180 ASN A ND2  1 
ATOM   2725 H H    . ASN A 1 180 ? -5.00043  31.18816 -0.47515  1.000 15.72198  ? 180 ASN A H    1 
ATOM   2726 H HA   . ASN A 1 180 ? -5.63224  29.59828 -2.54574  1.000 16.10874  ? 180 ASN A HA   1 
ATOM   2727 H HB2  . ASN A 1 180 ? -3.21833  29.65789 -1.02069  1.000 16.70766  ? 180 ASN A HB2  1 
ATOM   2728 H HB3  . ASN A 1 180 ? -3.40271  28.85041 -2.37693  1.000 16.70766  ? 180 ASN A HB3  1 
ATOM   2729 H HD21 . ASN A 1 180 ? -3.29444  31.56097 -4.40814  1.000 18.91421  ? 180 ASN A HD21 1 
ATOM   2730 H HD22 . ASN A 1 180 ? -4.04393  30.28794 -4.21718  1.000 18.91421  ? 180 ASN A HD22 1 
ATOM   2731 N N    . PHE A 1 181 ? -6.39795  27.58589 -1.47874  1.000 14.94979  ? 181 PHE A N    1 
ATOM   2732 C CA   . PHE A 1 181 ? -6.89529  26.42880 -0.73843  1.000 15.41226  ? 181 PHE A CA   1 
ATOM   2733 C C    . PHE A 1 181 ? -5.77710  25.57435 -0.17167  1.000 15.25768  ? 181 PHE A C    1 
ATOM   2734 O O    . PHE A 1 181 ? -4.69503  25.43572 -0.75827  1.000 13.89248  ? 181 PHE A O    1 
ATOM   2735 C CB   . PHE A 1 181 ? -7.82425  25.55448 -1.60156  1.000 12.97642  ? 181 PHE A CB   1 
ATOM   2736 C CG   . PHE A 1 181 ? -9.28080  25.84661 -1.40236  1.000 15.03771  ? 181 PHE A CG   1 
ATOM   2737 C CD1  . PHE A 1 181 ? -9.95185  25.23361 -0.36696  1.000 15.04594  ? 181 PHE A CD1  1 
ATOM   2738 C CD2  . PHE A 1 181 ? -9.91346  26.76831 -2.18127  1.000 16.58976  ? 181 PHE A CD2  1 
ATOM   2739 C CE1  . PHE A 1 181 ? -11.32427 25.49061 -0.16208  1.000 20.78623  ? 181 PHE A CE1  1 
ATOM   2740 C CE2  . PHE A 1 181 ? -11.27622 27.04538 -2.01491  1.000 15.06701  ? 181 PHE A CE2  1 
ATOM   2741 C CZ   . PHE A 1 181 ? -11.96447 26.42196 -0.94822  1.000 16.31261  ? 181 PHE A CZ   1 
ATOM   2742 H H    . PHE A 1 181 ? -6.65297  27.62820 -2.29897  1.000 17.93975  ? 181 PHE A H    1 
ATOM   2743 H HA   . PHE A 1 181 ? -7.40998  26.77661 0.00657   1.000 18.49471  ? 181 PHE A HA   1 
ATOM   2744 H HB2  . PHE A 1 181 ? -7.61646  25.70669 -2.53674  1.000 15.57171  ? 181 PHE A HB2  1 
ATOM   2745 H HB3  . PHE A 1 181 ? -7.67505  24.62296 -1.37592  1.000 15.57171  ? 181 PHE A HB3  1 
ATOM   2746 H HD1  . PHE A 1 181 ? -9.49960  24.64944 0.19794   1.000 18.05513  ? 181 PHE A HD1  1 
ATOM   2747 H HD2  . PHE A 1 181 ? -9.43177  27.22155 -2.83508  1.000 19.90772  ? 181 PHE A HD2  1 
ATOM   2748 H HE1  . PHE A 1 181 ? -11.79274 25.03420 0.49908   1.000 24.94348  ? 181 PHE A HE1  1 
ATOM   2749 H HE2  . PHE A 1 181 ? -11.71801 27.62549 -2.59214  1.000 18.08041  ? 181 PHE A HE2  1 
ATOM   2750 H HZ   . PHE A 1 181 ? -12.85184 26.64175 -0.77740  1.000 19.57513  ? 181 PHE A HZ   1 
ATOM   2751 N N    . TYR A 1 182 ? -6.03637  25.04700 1.02381   1.000 13.02855  ? 182 TYR A N    1 
ATOM   2752 C CA   . TYR A 1 182 ? -5.30099  23.90601 1.51307   1.000 10.95271  ? 182 TYR A CA   1 
ATOM   2753 C C    . TYR A 1 182 ? -5.88501  22.67412 0.86078   1.000 14.35579  ? 182 TYR A C    1 
ATOM   2754 O O    . TYR A 1 182 ? -7.06916  22.41793 0.98123   1.000 15.24438  ? 182 TYR A O    1 
ATOM   2755 C CB   . TYR A 1 182 ? -5.44181  23.79471 3.00973   1.000 12.48014  ? 182 TYR A CB   1 
ATOM   2756 C CG   . TYR A 1 182 ? -4.71013  24.83529 3.79722   1.000 11.70018  ? 182 TYR A CG   1 
ATOM   2757 C CD1  . TYR A 1 182 ? -3.30252  24.69907 3.97183   1.000 14.08781  ? 182 TYR A CD1  1 
ATOM   2758 C CD2  . TYR A 1 182 ? -5.31977  25.91497 4.33419   1.000 12.49435  ? 182 TYR A CD2  1 
ATOM   2759 C CE1  . TYR A 1 182 ? -2.57075  25.64957 4.71774   1.000 13.10756  ? 182 TYR A CE1  1 
ATOM   2760 C CE2  . TYR A 1 182 ? -4.61670  26.87620 5.04181   1.000 12.52823  ? 182 TYR A CE2  1 
ATOM   2761 C CZ   . TYR A 1 182 ? -3.23755  26.74397 5.27025   1.000 13.01183  ? 182 TYR A CZ   1 
ATOM   2762 O OH   . TYR A 1 182 ? -2.56276  27.65612 6.01217   1.000 13.22392  ? 182 TYR A OH   1 
ATOM   2763 H H    . TYR A 1 182 ? -6.63710  25.33953 1.56524   1.000 15.63425  ? 182 TYR A H    1 
ATOM   2764 H HA   . TYR A 1 182 ? -4.35938  23.99442 1.29756   1.000 13.14326  ? 182 TYR A HA   1 
ATOM   2765 H HB2  . TYR A 1 182 ? -6.38235  23.86852 3.23522   1.000 14.97617  ? 182 TYR A HB2  1 
ATOM   2766 H HB3  . TYR A 1 182 ? -5.10136  22.92943 3.28591   1.000 14.97617  ? 182 TYR A HB3  1 
ATOM   2767 H HD1  . TYR A 1 182 ? -2.86021  23.97554 3.59004   1.000 16.90537  ? 182 TYR A HD1  1 
ATOM   2768 H HD2  . TYR A 1 182 ? -6.23790  26.01569 4.22558   1.000 14.99323  ? 182 TYR A HD2  1 
ATOM   2769 H HE1  . TYR A 1 182 ? -1.65444  25.54716 4.83934   1.000 15.72907  ? 182 TYR A HE1  1 
ATOM   2770 H HE2  . TYR A 1 182 ? -5.06546  27.62130 5.37097   1.000 15.03387  ? 182 TYR A HE2  1 
ATOM   2771 H HH   . TYR A 1 182 ? -2.93283  28.40762 5.94978   1.000 15.86870  ? 182 TYR A HH   1 
ATOM   2772 N N    . GLY A 1 183 ? -5.08129  21.93935 0.10535   1.000 12.76109  ? 183 GLY A N    1 
ATOM   2773 C CA   . GLY A 1 183 ? -5.53289  20.69009 -0.44831  1.000 13.26311  ? 183 GLY A CA   1 
ATOM   2774 C C    . GLY A 1 183 ? -6.18969  20.87606 -1.80641  1.000 16.09597  ? 183 GLY A C    1 
ATOM   2775 O O    . GLY A 1 183 ? -6.36149  21.98984 -2.27495  1.000 13.64970  ? 183 GLY A O    1 
ATOM   2776 H H    . GLY A 1 183 ? -4.27206  22.14918 -0.09643  1.000 15.31331  ? 183 GLY A H    1 
ATOM   2777 H HA2  . GLY A 1 183 ? -4.77731  20.09062 -0.55146  1.000 15.91573  ? 183 GLY A HA2  1 
ATOM   2778 H HA3  . GLY A 1 183 ? -6.17775  20.28491 0.15243   1.000 15.91573  ? 183 GLY A HA3  1 
ATOM   2779 N N    . PRO A 1 184 ? -6.60983  19.77875 -2.38843  1.000 15.58626  ? 184 PRO A N    1 
ATOM   2780 C CA   . PRO A 1 184 ? -7.10732  19.77860 -3.78600  1.000 16.69529  ? 184 PRO A CA   1 
ATOM   2781 C C    . PRO A 1 184 ? -8.61005  20.04359 -3.83731  1.000 18.86614  ? 184 PRO A C    1 
ATOM   2782 O O    . PRO A 1 184 ? -9.40549  19.20876 -4.31930  1.000 25.62309  ? 184 PRO A O    1 
ATOM   2783 C CB   . PRO A 1 184 ? -6.77849  18.34747 -4.22752  1.000 18.53377  ? 184 PRO A CB   1 
ATOM   2784 C CG   . PRO A 1 184 ? -6.94361  17.54770 -2.98193  1.000 21.39581  ? 184 PRO A CG   1 
ATOM   2785 C CD   . PRO A 1 184 ? -6.42455  18.42144 -1.87500  1.000 18.64586  ? 184 PRO A CD   1 
ATOM   2786 H HA   . PRO A 1 184 ? -6.62763  20.42220 -4.33059  1.000 20.03435  ? 184 PRO A HA   1 
ATOM   2787 H HB2  . PRO A 1 184 ? -7.39749  18.05826 -4.91607  1.000 22.24052  ? 184 PRO A HB2  1 
ATOM   2788 H HB3  . PRO A 1 184 ? -5.86798  18.29937 -4.55849  1.000 22.24052  ? 184 PRO A HB3  1 
ATOM   2789 H HG2  . PRO A 1 184 ? -7.88127  17.33948 -2.84651  1.000 25.67497  ? 184 PRO A HG2  1 
ATOM   2790 H HG3  . PRO A 1 184 ? -6.42779  16.72872 -3.04599  1.000 25.67497  ? 184 PRO A HG3  1 
ATOM   2791 H HD2  . PRO A 1 184 ? -6.93780  18.28828 -1.06275  1.000 22.37503  ? 184 PRO A HD2  1 
ATOM   2792 H HD3  . PRO A 1 184 ? -5.48601  18.24259 -1.70746  1.000 22.37503  ? 184 PRO A HD3  1 
ATOM   2793 N N    . PHE A 1 185 ? -9.01309  21.17438 -3.30511  1.000 16.65475  ? 185 PHE A N    1 
ATOM   2794 C CA   . PHE A 1 185 ? -10.43791 21.49659 -3.13690  1.000 16.49942  ? 185 PHE A CA   1 
ATOM   2795 C C    . PHE A 1 185 ? -10.71105 22.82047 -3.81494  1.000 17.03498  ? 185 PHE A C    1 
ATOM   2796 O O    . PHE A 1 185 ? -9.81256  23.63567 -4.01505  1.000 21.59880  ? 185 PHE A O    1 
ATOM   2797 C CB   . PHE A 1 185 ? -10.85010 21.58128 -1.68012  1.000 20.02104  ? 185 PHE A CB   1 
ATOM   2798 C CG   . PHE A 1 185 ? -10.49716 20.35449 -0.91042  1.000 19.21128  ? 185 PHE A CG   1 
ATOM   2799 C CD1  . PHE A 1 185 ? -11.09494 19.14629 -1.19847  1.000 16.35563  ? 185 PHE A CD1  1 
ATOM   2800 C CD2  . PHE A 1 185 ? -9.50628  20.37485 0.06881   1.000 18.28506  ? 185 PHE A CD2  1 
ATOM   2801 C CE1  . PHE A 1 185 ? -10.75178 18.00382 -0.51838  1.000 18.75985  ? 185 PHE A CE1  1 
ATOM   2802 C CE2  . PHE A 1 185 ? -9.17979  19.25561 0.73346   1.000 16.33109  ? 185 PHE A CE2  1 
ATOM   2803 C CZ   . PHE A 1 185 ? -9.76367  18.04632 0.44610   1.000 18.63325  ? 185 PHE A CZ   1 
ATOM   2804 H H    . PHE A 1 185 ? -8.48215  21.79012 -3.02481  1.000 19.98570  ? 185 PHE A H    1 
ATOM   2805 H HA   . PHE A 1 185 ? -10.97604 20.79907 -3.54283  1.000 19.79930  ? 185 PHE A HA   1 
ATOM   2806 H HB2  . PHE A 1 185 ? -10.39978 22.33489 -1.26760  1.000 24.02525  ? 185 PHE A HB2  1 
ATOM   2807 H HB3  . PHE A 1 185 ? -11.81135 21.70131 -1.63017  1.000 24.02525  ? 185 PHE A HB3  1 
ATOM   2808 H HD1  . PHE A 1 185 ? -11.74202 19.10417 -1.86511  1.000 19.62675  ? 185 PHE A HD1  1 
ATOM   2809 H HD2  . PHE A 1 185 ? -9.06718  21.17118 0.26361   1.000 21.94207  ? 185 PHE A HD2  1 
ATOM   2810 H HE1  . PHE A 1 185 ? -11.18411 17.20228 -0.70686  1.000 22.51182  ? 185 PHE A HE1  1 
ATOM   2811 H HE2  . PHE A 1 185 ? -8.54040  19.30018 1.40733   1.000 19.59731  ? 185 PHE A HE2  1 
ATOM   2812 H HZ   . PHE A 1 185 ? -9.49980  17.27334 0.89081   1.000 22.35990  ? 185 PHE A HZ   1 
ATOM   2813 N N    . VAL A 1 186 ? -11.96917 22.99279 -4.24364  1.000 18.15996  ? 186 VAL A N    1 
ATOM   2814 C CA   . VAL A 1 186 ? -12.39589 24.16426 -5.01136  1.000 18.57728  ? 186 VAL A CA   1 
ATOM   2815 C C    . VAL A 1 186 ? -13.70622 24.67123 -4.43671  1.000 20.55093  ? 186 VAL A C    1 
ATOM   2816 O O    . VAL A 1 186 ? -14.52099 23.89447 -3.91052  1.000 20.66016  ? 186 VAL A O    1 
ATOM   2817 C CB   . VAL A 1 186 ? -12.57276 23.84375 -6.53100  1.000 19.13699  ? 186 VAL A CB   1 
ATOM   2818 C CG1  . VAL A 1 186 ? -11.19535 23.54421 -7.15445  1.000 23.24581  ? 186 VAL A CG1  1 
ATOM   2819 C CG2  . VAL A 1 186 ? -13.48281 22.67753 -6.72546  1.000 21.69294  ? 186 VAL A CG2  1 
ATOM   2820 H H    . VAL A 1 186 ? -12.60411 22.43145 -4.09752  1.000 21.79195  ? 186 VAL A H    1 
ATOM   2821 H HA   . VAL A 1 186 ? -11.72274 24.85672 -4.92044  1.000 22.29273  ? 186 VAL A HA   1 
ATOM   2822 H HB   . VAL A 1 186 ? -12.96901 24.61063 -6.97347  1.000 22.96439  ? 186 VAL A HB   1 
ATOM   2823 H HG11 . VAL A 1 186 ? -10.73053 22.89945 -6.59846  1.000 27.89498  ? 186 VAL A HG11 1 
ATOM   2824 H HG12 . VAL A 1 186 ? -11.32387 23.18141 -8.04482  1.000 27.89498  ? 186 VAL A HG12 1 
ATOM   2825 H HG13 . VAL A 1 186 ? -10.68501 24.36766 -7.20329  1.000 27.89498  ? 186 VAL A HG13 1 
ATOM   2826 H HG21 . VAL A 1 186 ? -14.30629 22.83474 -6.23753  1.000 26.03153  ? 186 VAL A HG21 1 
ATOM   2827 H HG22 . VAL A 1 186 ? -13.67256 22.57934 -7.67164  1.000 26.03153  ? 186 VAL A HG22 1 
ATOM   2828 H HG23 . VAL A 1 186 ? -13.04747 21.87797 -6.39069  1.000 26.03153  ? 186 VAL A HG23 1 
ATOM   2829 N N    . ASP A 1 187 ? -13.89396 25.99158 -4.52276  1.000 15.63053  ? 187 ASP A N    1 
ATOM   2830 C CA   . ASP A 1 187 ? -15.10652 26.61626 -3.96704  1.000 17.93194  ? 187 ASP A CA   1 
ATOM   2831 C C    . ASP A 1 187 ? -16.25901 26.60420 -4.97435  1.000 29.90123  ? 187 ASP A C    1 
ATOM   2832 O O    . ASP A 1 187 ? -16.76542 27.63672 -5.40067  1.000 27.00824  ? 187 ASP A O    1 
ATOM   2833 C CB   . ASP A 1 187 ? -14.82371 28.01655 -3.44894  1.000 18.68426  ? 187 ASP A CB   1 
ATOM   2834 C CG   . ASP A 1 187 ? -14.09873 28.91685 -4.43326  1.000 17.46702  ? 187 ASP A CG   1 
ATOM   2835 O OD1  . ASP A 1 187 ? -13.62287 28.44559 -5.48692  1.000 20.15117  ? 187 ASP A OD1  1 
ATOM   2836 O OD2  . ASP A 1 187 ? -14.02597 30.12205 -4.10350  1.000 18.82356  ? 187 ASP A OD2  1 
ATOM   2837 H H    . ASP A 1 187 ? -13.34445 26.54073 -4.89165  1.000 18.75663  ? 187 ASP A H    1 
ATOM   2838 H HA   . ASP A 1 187 ? -15.38104 26.07915 -3.20740  1.000 21.51832  ? 187 ASP A HA   1 
ATOM   2839 H HB2  . ASP A 1 187 ? -15.66759 28.44187 -3.23012  1.000 22.42112  ? 187 ASP A HB2  1 
ATOM   2840 H HB3  . ASP A 1 187 ? -14.27147 27.94694 -2.65453  1.000 22.42112  ? 187 ASP A HB3  1 
ATOM   2841 N N    . ARG A 1 188 ? -16.64804 25.39328 -5.34506  1.000 29.51984  ? 188 ARG A N    1 
ATOM   2842 C CA   . ARG A 1 188 ? -17.77116 25.14780 -6.24738  1.000 43.76003  ? 188 ARG A CA   1 
ATOM   2843 C C    . ARG A 1 188 ? -18.29013 23.74610 -5.95733  1.000 59.31674  ? 188 ARG A C    1 
ATOM   2844 O O    . ARG A 1 188 ? -17.69066 22.98886 -5.18689  1.000 39.71361  ? 188 ARG A O    1 
ATOM   2845 C CB   . ARG A 1 188 ? -17.37656 25.31113 -7.71671  1.000 41.26684  ? 188 ARG A CB   1 
ATOM   2846 C CG   . ARG A 1 188 ? -16.29215 24.37564 -8.21370  1.000 48.10162  ? 188 ARG A CG   1 
ATOM   2847 C CD   . ARG A 1 188 ? -15.99442 24.61752 -9.69178  1.000 52.54032  ? 188 ARG A CD   1 
ATOM   2848 N NE   . ARG A 1 188 ? -15.26889 23.50884 -10.29733 1.000 49.07826  ? 188 ARG A NE   1 
ATOM   2849 C CZ   . ARG A 1 188 ? -13.95530 23.45860 -10.44985 1.000 41.61287  ? 188 ARG A CZ   1 
ATOM   2850 N NH1  . ARG A 1 188 ? -13.17829 24.47314 -10.09136 1.000 53.11384  ? 188 ARG A NH1  1 
ATOM   2851 N NH2  . ARG A 1 188 ? -13.40270 22.35406 -10.95975 1.000 52.77075  ? 188 ARG A NH2  1 
ATOM   2852 H H    . ARG A 1 188 ? -16.26671 24.66931 -5.08040  1.000 35.42381  ? 188 ARG A H    1 
ATOM   2853 H HA   . ARG A 1 188 ? -18.47814 25.78802 -6.07071  1.000 52.51203  ? 188 ARG A HA   1 
ATOM   2854 H HB2  . ARG A 1 188 ? -18.16337 25.15538 -8.26221  1.000 49.52020  ? 188 ARG A HB2  1 
ATOM   2855 H HB3  . ARG A 1 188 ? -17.05671 26.21758 -7.84693  1.000 49.52020  ? 188 ARG A HB3  1 
ATOM   2856 H HG2  . ARG A 1 188 ? -15.47830 24.52692 -7.70807  1.000 57.72194  ? 188 ARG A HG2  1 
ATOM   2857 H HG3  . ARG A 1 188 ? -16.58377 23.45682 -8.10587  1.000 57.72194  ? 188 ARG A HG3  1 
ATOM   2858 H HD2  . ARG A 1 188 ? -16.83058 24.72854 -10.17074 1.000 63.04839  ? 188 ARG A HD2  1 
ATOM   2859 H HD3  . ARG A 1 188 ? -15.45258 25.41717 -9.78048  1.000 63.04839  ? 188 ARG A HD3  1 
ATOM   2860 H HE   . ARG A 1 188 ? -15.72816 22.83739 -10.57631 1.000 58.89391  ? 188 ARG A HE   1 
ATOM   2861 H HH11 . ARG A 1 188 ? -13.52653 25.18243 -9.75188  1.000 63.73660  ? 188 ARG A HH11 1 
ATOM   2862 H HH12 . ARG A 1 188 ? -12.32658 24.42124 -10.19855 1.000 63.73660  ? 188 ARG A HH12 1 
ATOM   2863 H HH21 . ARG A 1 188 ? -13.89947 21.68871 -11.18364 1.000 63.32490  ? 188 ARG A HH21 1 
ATOM   2864 H HH22 . ARG A 1 188 ? -12.55027 22.30851 -11.06405 1.000 63.32490  ? 188 ARG A HH22 1 
ATOM   2865 N N    . GLN A 1 189 ? -19.42048 23.40703 -6.56836  1.000 64.20724  ? 189 GLN A N    1 
ATOM   2866 C CA   . GLN A 1 189 ? -20.07626 22.13158 -6.28777  1.000 73.73401  ? 189 GLN A CA   1 
ATOM   2867 C C    . GLN A 1 189 ? -19.52591 21.05737 -7.22406  1.000 57.44632  ? 189 GLN A C    1 
ATOM   2868 O O    . GLN A 1 189 ? -19.76962 21.08426 -8.43407  1.000 44.75174  ? 189 GLN A O    1 
ATOM   2869 C CB   . GLN A 1 189 ? -21.59376 22.23651 -6.41106  1.000 64.60930  ? 189 GLN A CB   1 
ATOM   2870 C CG   . GLN A 1 189 ? -22.32437 21.17946 -5.60345  1.000 57.20951  ? 189 GLN A CG   1 
ATOM   2871 C CD   . GLN A 1 189 ? -21.95020 21.21268 -4.13281  1.000 89.47398  ? 189 GLN A CD   1 
ATOM   2872 O OE1  . GLN A 1 189 ? -21.80974 20.16833 -3.49069  1.000 97.85479  ? 189 GLN A OE1  1 
ATOM   2873 N NE2  . GLN A 1 189 ? -21.77881 22.41952 -3.59339  1.000 85.96589  ? 189 GLN A NE2  1 
ATOM   2874 H H    . GLN A 1 189 ? -19.82646 23.89625 -7.14754  1.000 77.04869  ? 189 GLN A H    1 
ATOM   2875 H HA   . GLN A 1 189 ? -19.86548 21.88092 -5.37473  1.000 88.48081  ? 189 GLN A HA   1 
ATOM   2876 H HB2  . GLN A 1 189 ? -21.87674 23.10742 -6.09118  1.000 77.53116  ? 189 GLN A HB2  1 
ATOM   2877 H HB3  . GLN A 1 189 ? -21.84281 22.12811 -7.34226  1.000 77.53116  ? 189 GLN A HB3  1 
ATOM   2878 H HG2  . GLN A 1 189 ? -23.27998 21.32993 -5.67467  1.000 68.65141  ? 189 GLN A HG2  1 
ATOM   2879 H HG3  . GLN A 1 189 ? -22.09974 20.30247 -5.95176  1.000 68.65141  ? 189 GLN A HG3  1 
ATOM   2880 H HE21 . GLN A 1 189 ? -21.56606 22.49326 -2.76339  1.000 103.15907 ? 189 GLN A HE21 1 
ATOM   2881 H HE22 . GLN A 1 189 ? -21.88099 23.12440 -4.07537  1.000 103.15907 ? 189 GLN A HE22 1 
ATOM   2882 N N    . THR A 1 190 ? -18.77608 20.12078 -6.65256  1.000 39.65954  ? 190 THR A N    1 
ATOM   2883 C CA   . THR A 1 190 ? -18.36437 18.91221 -7.33231  1.000 36.42165  ? 190 THR A CA   1 
ATOM   2884 C C    . THR A 1 190 ? -18.57202 17.75818 -6.35867  1.000 45.78759  ? 190 THR A C    1 
ATOM   2885 O O    . THR A 1 190 ? -19.04342 17.94048 -5.22370  1.000 33.76176  ? 190 THR A O    1 
ATOM   2886 C CB   . THR A 1 190 ? -16.89474 18.97276 -7.78132  1.000 49.10066  ? 190 THR A CB   1 
ATOM   2887 O OG1  . THR A 1 190 ? -16.04221 18.90588 -6.62918  1.000 41.52611  ? 190 THR A OG1  1 
ATOM   2888 C CG2  . THR A 1 190 ? -16.60528 20.26197 -8.55563  1.000 43.97662  ? 190 THR A CG2  1 
ATOM   2889 H H    . THR A 1 190 ? -18.48666 20.16998 -5.84422  1.000 47.59145  ? 190 THR A H    1 
ATOM   2890 H HA   . THR A 1 190 ? -18.91162 18.79056 -8.12390  1.000 43.70598  ? 190 THR A HA   1 
ATOM   2891 H HB   . THR A 1 190 ? -16.70953 18.22493 -8.37068  1.000 58.92080  ? 190 THR A HB   1 
ATOM   2892 H HG1  . THR A 1 190 ? -15.96377 19.66819 -6.28519  1.000 49.83133  ? 190 THR A HG1  1 
ATOM   2893 H HG21 . THR A 1 190 ? -16.83128 21.03311 -8.01235  1.000 52.77195  ? 190 THR A HG21 1 
ATOM   2894 H HG22 . THR A 1 190 ? -15.66450 20.30534 -8.78790  1.000 52.77195  ? 190 THR A HG22 1 
ATOM   2895 H HG23 . THR A 1 190 ? -17.13196 20.28528 -9.36986  1.000 52.77195  ? 190 THR A HG23 1 
ATOM   2896 N N    . ALA A 1 191 ? -18.20510 16.55631 -6.79648  1.000 50.42569  ? 191 ALA A N    1 
ATOM   2897 C CA   . ALA A 1 191 ? -18.20609 15.40160 -5.91432  1.000 47.77472  ? 191 ALA A CA   1 
ATOM   2898 C C    . ALA A 1 191 ? -16.92657 15.29998 -5.10458  1.000 36.88256  ? 191 ALA A C    1 
ATOM   2899 O O    . ALA A 1 191 ? -16.58578 14.19495 -4.64573  1.000 33.78177  ? 191 ALA A O    1 
ATOM   2900 C CB   . ALA A 1 191 ? -18.41312 14.11547 -6.72125  1.000 41.98006  ? 191 ALA A CB   1 
ATOM   2901 H H    . ALA A 1 191 ? -17.95213 16.38847 -7.60112  1.000 60.51083  ? 191 ALA A H    1 
ATOM   2902 H HA   . ALA A 1 191 ? -18.95170 15.48398 -5.29936  1.000 57.32966  ? 191 ALA A HA   1 
ATOM   2903 H HB1  . ALA A 1 191 ? -18.57689 13.38131 -6.10880  1.000 50.37607  ? 191 ALA A HB1  1 
ATOM   2904 H HB2  . ALA A 1 191 ? -19.17521 14.23130 -7.31006  1.000 50.37607  ? 191 ALA A HB2  1 
ATOM   2905 H HB3  . ALA A 1 191 ? -17.61526 13.93861 -7.24378  1.000 50.37607  ? 191 ALA A HB3  1 
ATOM   2906 N N    . GLN A 1 192 ? -16.21827 16.41545 -4.92914  1.000 32.41318  ? 192 GLN A N    1 
ATOM   2907 C CA   . GLN A 1 192 ? -14.91470 16.38432 -4.26752  1.000 25.32340  ? 192 GLN A CA   1 
ATOM   2908 C C    . GLN A 1 192 ? -15.02532 15.77172 -2.87958  1.000 28.81946  ? 192 GLN A C    1 
ATOM   2909 O O    . GLN A 1 192 ? -16.02464 15.93529 -2.17231  1.000 34.88763  ? 192 GLN A O    1 
ATOM   2910 C CB   . GLN A 1 192 ? -14.32034 17.79437 -4.16087  1.000 29.60445  ? 192 GLN A CB   1 
ATOM   2911 C CG   . GLN A 1 192 ? -15.20565 18.84340 -3.55062  1.000 28.39045  ? 192 GLN A CG   1 
ATOM   2912 C CD   . GLN A 1 192 ? -14.64559 20.26454 -3.74491  1.000 21.29570  ? 192 GLN A CD   1 
ATOM   2913 O OE1  . GLN A 1 192 ? -13.44332 20.45812 -3.84598  1.000 22.74971  ? 192 GLN A OE1  1 
ATOM   2914 N NE2  . GLN A 1 192 ? -15.52260 21.24216 -3.82600  1.000 20.92335  ? 192 GLN A NE2  1 
ATOM   2915 H H    . GLN A 1 192 ? -16.46816 17.19845 -5.18227  1.000 38.89582  ? 192 GLN A H    1 
ATOM   2916 H HA   . GLN A 1 192 ? -14.31142 15.84064 -4.79796  1.000 30.38808  ? 192 GLN A HA   1 
ATOM   2917 H HB2  . GLN A 1 192 ? -13.51946 17.74431 -3.61591  1.000 35.52534  ? 192 GLN A HB2  1 
ATOM   2918 H HB3  . GLN A 1 192 ? -14.09498 18.09573 -5.05490  1.000 35.52534  ? 192 GLN A HB3  1 
ATOM   2919 H HG2  . GLN A 1 192 ? -16.08020 18.80370 -3.96833  1.000 34.06854  ? 192 GLN A HG2  1 
ATOM   2920 H HG3  . GLN A 1 192 ? -15.28507 18.67767 -2.59819  1.000 34.06854  ? 192 GLN A HG3  1 
ATOM   2921 H HE21 . GLN A 1 192 ? -16.36358 21.07111 -3.77039  1.000 25.10802  ? 192 GLN A HE21 1 
ATOM   2922 H HE22 . GLN A 1 192 ? -15.25481 22.05216 -3.93459  1.000 25.10802  ? 192 GLN A HE22 1 
ATOM   2923 N N    . ALA A 1 193 ? -13.97211 15.05461 -2.50186  1.000 23.00312  ? 193 ALA A N    1 
ATOM   2924 C CA   . ALA A 1 193 ? -13.95637 14.28305 -1.26530  1.000 28.19449  ? 193 ALA A CA   1 
ATOM   2925 C C    . ALA A 1 193 ? -12.53984 14.29817 -0.70825  1.000 26.06903  ? 193 ALA A C    1 
ATOM   2926 O O    . ALA A 1 193 ? -11.56282 14.37534 -1.46307  1.000 28.21620  ? 193 ALA A O    1 
ATOM   2927 C CB   . ALA A 1 193 ? -14.37140 12.81641 -1.48887  1.000 32.20425  ? 193 ALA A CB   1 
ATOM   2928 H H    . ALA A 1 193 ? -13.24190 14.99789 -2.95260  1.000 27.60375  ? 193 ALA A H    1 
ATOM   2929 H HA   . ALA A 1 193 ? -14.57012 14.69083 -0.63449  1.000 33.83339  ? 193 ALA A HA   1 
ATOM   2930 H HB1  . ALA A 1 193 ? -14.28503 12.33276 -0.65250  1.000 38.64510  ? 193 ALA A HB1  1 
ATOM   2931 H HB2  . ALA A 1 193 ? -15.29256 12.79154 -1.79176  1.000 38.64510  ? 193 ALA A HB2  1 
ATOM   2932 H HB3  . ALA A 1 193 ? -13.79184 12.42298 -2.15986  1.000 38.64510  ? 193 ALA A HB3  1 
ATOM   2933 N N    . ALA A 1 194 ? -12.45597 14.19555 0.62666   1.000 25.98472  ? 194 ALA A N    1 
ATOM   2934 C CA   . ALA A 1 194 ? -11.15079 14.10550 1.27503   1.000 32.12131  ? 194 ALA A CA   1 
ATOM   2935 C C    . ALA A 1 194 ? -10.43244 12.85185 0.79006   1.000 32.98184  ? 194 ALA A C    1 
ATOM   2936 O O    . ALA A 1 194 ? -11.03707 11.78539 0.65896   1.000 30.86487  ? 194 ALA A O    1 
ATOM   2937 C CB   . ALA A 1 194 ? -11.34513 14.02985 2.79518   1.000 29.57132  ? 194 ALA A CB   1 
ATOM   2938 H H    . ALA A 1 194 ? -13.12776 14.17673 1.16326   1.000 31.18166  ? 194 ALA A H    1 
ATOM   2939 H HA   . ALA A 1 194 ? -10.61159 14.88414 1.06552   1.000 38.54557  ? 194 ALA A HA   1 
ATOM   2940 H HB1  . ALA A 1 194 ? -11.84343 13.22589 3.01022   1.000 35.48559  ? 194 ALA A HB1  1 
ATOM   2941 H HB2  . ALA A 1 194 ? -10.47538 14.00453 3.22387   1.000 35.48559  ? 194 ALA A HB2  1 
ATOM   2942 H HB3  . ALA A 1 194 ? -11.83659 14.81242 3.09005   1.000 35.48559  ? 194 ALA A HB3  1 
ATOM   2943 N N    . GLY A 1 195 ? -9.14235  12.98785 0.51818   1.000 29.02510  ? 195 GLY A N    1 
ATOM   2944 C CA   . GLY A 1 195 ? -8.30882  11.85394 0.23103   1.000 36.33122  ? 195 GLY A CA   1 
ATOM   2945 C C    . GLY A 1 195 ? -7.97148  11.07823 1.50836   1.000 30.43628  ? 195 GLY A C    1 
ATOM   2946 O O    . GLY A 1 195 ? -8.35141  11.44442 2.62481   1.000 30.14365  ? 195 GLY A O    1 
ATOM   2947 H H    . GLY A 1 195 ? -8.72837  13.74131 0.49571   1.000 34.83013  ? 195 GLY A H    1 
ATOM   2948 H HA2  . GLY A 1 195 ? -8.76810  11.25888 -0.38204  1.000 43.59747  ? 195 GLY A HA2  1 
ATOM   2949 H HA3  . GLY A 1 195 ? -7.48201  12.15282 -0.17881  1.000 43.59747  ? 195 GLY A HA3  1 
ATOM   2950 N N    . THR A 1 196 ? -7.23787  9.97962  1.32735   1.000 30.95727  ? 196 THR A N    1 
ATOM   2951 C CA   . THR A 1 196 ? -6.90532  9.14082  2.46779   1.000 31.82147  ? 196 THR A CA   1 
ATOM   2952 C C    . THR A 1 196 ? -6.01869  9.90164  3.44743   1.000 24.21475  ? 196 THR A C    1 
ATOM   2953 O O    . THR A 1 196 ? -5.14191  10.66689 3.05011   1.000 29.09581  ? 196 THR A O    1 
ATOM   2954 C CB   . THR A 1 196 ? -6.19160  7.86658  2.00293   1.000 35.64515  ? 196 THR A CB   1 
ATOM   2955 O OG1  . THR A 1 196 ? -5.01188  8.23336  1.26773   1.000 40.57151  ? 196 THR A OG1  1 
ATOM   2956 C CG2  . THR A 1 196 ? -7.12733  7.03378  1.11309   1.000 31.67500  ? 196 THR A CG2  1 
ATOM   2957 H H    . THR A 1 196 ? -6.92989  9.70781  0.57179   1.000 37.14873  ? 196 THR A H    1 
ATOM   2958 H HA   . THR A 1 196 ? -7.72202  8.88358  2.92355   1.000 38.18577  ? 196 THR A HA   1 
ATOM   2959 H HB   . THR A 1 196 ? -5.93803  7.32308  2.76530   1.000 42.77418  ? 196 THR A HB   1 
ATOM   2960 H HG1  . THR A 1 196 ? -5.22222  8.69771  0.60009   1.000 48.68581  ? 196 THR A HG1  1 
ATOM   2961 H HG21 . THR A 1 196 ? -6.61659  6.36860  0.62567   1.000 38.01000  ? 196 THR A HG21 1 
ATOM   2962 H HG22 . THR A 1 196 ? -7.79058  6.58344  1.65915   1.000 38.01000  ? 196 THR A HG22 1 
ATOM   2963 H HG23 . THR A 1 196 ? -7.58094  7.60988  0.47806   1.000 38.01000  ? 196 THR A HG23 1 
ATOM   2964 N N    . ASP A 1 197 ? -6.27588  9.69897  4.70923   1.000 27.04340  ? 197 ASP A N    1 
ATOM   2965 C CA   . ASP A 1 197 ? -5.53669  10.38427 5.76327   1.000 25.08464  ? 197 ASP A CA   1 
ATOM   2966 C C    . ASP A 1 197 ? -4.58841  9.38358  6.44423   1.000 31.63359  ? 197 ASP A C    1 
ATOM   2967 O O    . ASP A 1 197 ? -4.70479  8.16541  6.28040   1.000 30.66201  ? 197 ASP A O    1 
ATOM   2968 C CB   . ASP A 1 197 ? -6.47768  11.00995 6.77859   1.000 22.99644  ? 197 ASP A CB   1 
ATOM   2969 C CG   . ASP A 1 197 ? -5.87316  12.25961 7.46357   1.000 26.57121  ? 197 ASP A CG   1 
ATOM   2970 O OD1  . ASP A 1 197 ? -4.95603  12.93198 6.87363   1.000 23.46933  ? 197 ASP A OD1  1 
ATOM   2971 O OD2  . ASP A 1 197 ? -6.32223  12.58129 8.57038   1.000 26.36787  ? 197 ASP A OD2  1 
ATOM   2972 H H    . ASP A 1 197 ? -6.88238  9.16201  4.99805   1.000 32.45209  ? 197 ASP A H    1 
ATOM   2973 H HA   . ASP A 1 197 ? -5.00687  11.10390 5.38599   1.000 30.10157  ? 197 ASP A HA   1 
ATOM   2974 H HB2  . ASP A 1 197 ? -7.29393  11.27946 6.32915   1.000 27.59573  ? 197 ASP A HB2  1 
ATOM   2975 H HB3  . ASP A 1 197 ? -6.67834  10.35754 7.46780   1.000 27.59573  ? 197 ASP A HB3  1 
ATOM   2976 N N    . THR A 1 198 ? -3.61993  9.92954  7.18183   1.000 22.97160  ? 198 THR A N    1 
ATOM   2977 C CA   . THR A 1 198 ? -2.66752  9.14960  7.94424   1.000 22.13136  ? 198 THR A CA   1 
ATOM   2978 C C    . THR A 1 198 ? -2.51756  9.81259  9.31424   1.000 22.78724  ? 198 THR A C    1 
ATOM   2979 O O    . THR A 1 198 ? -2.98592  10.93586 9.53353   1.000 19.54090  ? 198 THR A O    1 
ATOM   2980 C CB   . THR A 1 198 ? -1.30999  9.06919  7.26983   1.000 28.97475  ? 198 THR A CB   1 
ATOM   2981 O OG1  . THR A 1 198 ? -0.78254  10.39517 7.09103   1.000 32.41377  ? 198 THR A OG1  1 
ATOM   2982 C CG2  . THR A 1 198 ? -1.44350  8.42367  5.88430   1.000 36.69126  ? 198 THR A CG2  1 
ATOM   2983 H H    . THR A 1 198 ? -3.49673  10.77763 7.25374   1.000 27.56592  ? 198 THR A H    1 
ATOM   2984 H HA   . THR A 1 198 ? -3.00452  8.24534  8.04242   1.000 26.55763  ? 198 THR A HA   1 
ATOM   2985 H HB   . THR A 1 198 ? -0.71114  8.53910  7.81873   1.000 34.76970  ? 198 THR A HB   1 
ATOM   2986 H HG1  . THR A 1 198 ? -0.05910  10.36162 6.66546   1.000 38.89653  ? 198 THR A HG1  1 
ATOM   2987 H HG21 . THR A 1 198 ? -2.32106  8.02159  5.78880   1.000 44.02951  ? 198 THR A HG21 1 
ATOM   2988 H HG22 . THR A 1 198 ? -1.32766  9.09442  5.19324   1.000 44.02951  ? 198 THR A HG22 1 
ATOM   2989 H HG23 . THR A 1 198 ? -0.76838  7.73626  5.77212   1.000 44.02951  ? 198 THR A HG23 1 
ATOM   2990 N N    . THR A 1 199 ? -1.91521  9.08275  10.25654  1.000 20.04752  ? 199 THR A N    1 
ATOM   2991 C CA   . THR A 1 199 ? -1.71580  9.58367  11.61125  1.000 21.10783  ? 199 THR A CA   1 
ATOM   2992 C C    . THR A 1 199 ? -0.38103  10.28478 11.70352  1.000 18.68585  ? 199 THR A C    1 
ATOM   2993 O O    . THR A 1 199 ? 0.61802   9.82825  11.15652  1.000 20.39352  ? 199 THR A O    1 
ATOM   2994 C CB   . THR A 1 199 ? -1.79452  8.42331  12.60182  1.000 19.22191  ? 199 THR A CB   1 
ATOM   2995 O OG1  . THR A 1 199 ? -3.10412  7.85854  12.60743  1.000 22.37634  ? 199 THR A OG1  1 
ATOM   2996 C CG2  . THR A 1 199 ? -1.45529  8.87351  14.01780  1.000 20.83172  ? 199 THR A CG2  1 
ATOM   2997 H H    . THR A 1 199 ? -1.61181  8.28787  10.13115  1.000 24.05703  ? 199 THR A H    1 
ATOM   2998 H HA   . THR A 1 199 ? -2.40271  10.22711 11.84586  1.000 25.32940  ? 199 THR A HA   1 
ATOM   2999 H HB   . THR A 1 199 ? -1.14980  7.75248  12.32756  1.000 23.06629  ? 199 THR A HB   1 
ATOM   3000 H HG1  . THR A 1 199 ? -3.65463  8.41263  12.91650  1.000 26.85161  ? 199 THR A HG1  1 
ATOM   3001 H HG21 . THR A 1 199 ? -1.68523  8.17621  14.65167  1.000 24.99806  ? 199 THR A HG21 1 
ATOM   3002 H HG22 . THR A 1 199 ? -0.50633  9.06196  14.08762  1.000 24.99806  ? 199 THR A HG22 1 
ATOM   3003 H HG23 . THR A 1 199 ? -1.95276  9.67637  14.23880  1.000 24.99806  ? 199 THR A HG23 1 
ATOM   3004 N N    . ILE A 1 200 ? -0.35619  11.39074 12.44428  1.000 17.93415  ? 200 ILE A N    1 
ATOM   3005 C CA   . ILE A 1 200 ? 0.81266   12.25466 12.53970  1.000 17.83028  ? 200 ILE A CA   1 
ATOM   3006 C C    . ILE A 1 200 ? 1.73523   11.71055 13.62892  1.000 17.44651  ? 200 ILE A C    1 
ATOM   3007 O O    . ILE A 1 200 ? 1.59767   12.07359 14.78503  1.000 17.38722  ? 200 ILE A O    1 
ATOM   3008 C CB   . ILE A 1 200 ? 0.42061   13.69417 12.85903  1.000 18.05267  ? 200 ILE A CB   1 
ATOM   3009 C CG1  . ILE A 1 200 ? -0.62044  14.20709 11.80917  1.000 17.52896  ? 200 ILE A CG1  1 
ATOM   3010 C CG2  . ILE A 1 200 ? 1.66149   14.59463 12.83331  1.000 20.05049  ? 200 ILE A CG2  1 
ATOM   3011 C CD1  . ILE A 1 200 ? -1.48047  15.37225 12.33449  1.000 20.10708  ? 200 ILE A CD1  1 
ATOM   3012 H H    . ILE A 1 200 ? -1.02279  11.66703 12.91217  1.000 21.52098  ? 200 ILE A H    1 
ATOM   3013 H HA   . ILE A 1 200 ? 1.27949   12.21527 11.69033  1.000 21.39634  ? 200 ILE A HA   1 
ATOM   3014 H HB   . ILE A 1 200 ? 0.02439   13.71934 13.74406  1.000 21.66321  ? 200 ILE A HB   1 
ATOM   3015 H HG12 . ILE A 1 200 ? -0.14676  14.51624 11.02117  1.000 21.03476  ? 200 ILE A HG12 1 
ATOM   3016 H HG13 . ILE A 1 200 ? -1.21557  13.47816 11.57384  1.000 21.03476  ? 200 ILE A HG13 1 
ATOM   3017 H HG21 . ILE A 1 200 ? 2.16912   14.40985 12.02766  1.000 24.06059  ? 200 ILE A HG21 1 
ATOM   3018 H HG22 . ILE A 1 200 ? 1.37861   15.52244 12.84052  1.000 24.06059  ? 200 ILE A HG22 1 
ATOM   3019 H HG23 . ILE A 1 200 ? 2.20341   14.40796 13.61585  1.000 24.06059  ? 200 ILE A HG23 1 
ATOM   3020 H HD11 . ILE A 1 200 ? -0.92316  15.96102 12.86709  1.000 24.12849  ? 200 ILE A HD11 1 
ATOM   3021 H HD12 . ILE A 1 200 ? -1.84858  15.85823 11.58002  1.000 24.12849  ? 200 ILE A HD12 1 
ATOM   3022 H HD13 . ILE A 1 200 ? -2.19856  15.01408 12.87941  1.000 24.12849  ? 200 ILE A HD13 1 
ATOM   3023 N N    . THR A 1 201 ? 2.73492   10.90911 13.23596  1.000 16.39378  ? 201 THR A N    1 
ATOM   3024 C CA   . THR A 1 201 ? 3.52333   10.13369 14.20051  1.000 17.26605  ? 201 THR A CA   1 
ATOM   3025 C C    . THR A 1 201 ? 4.26848   11.00706 15.19084  1.000 16.57561  ? 201 THR A C    1 
ATOM   3026 O O    . THR A 1 201 ? 4.24989   10.72894 16.41901  1.000 15.72608  ? 201 THR A O    1 
ATOM   3027 C CB   . THR A 1 201 ? 4.53426   9.29943  13.40000  1.000 19.90037  ? 201 THR A CB   1 
ATOM   3028 O OG1  . THR A 1 201 ? 3.81350   8.56949  12.40294  1.000 20.22555  ? 201 THR A OG1  1 
ATOM   3029 C CG2  . THR A 1 201 ? 5.32163   8.37833  14.35934  1.000 22.44292  ? 201 THR A CG2  1 
ATOM   3030 H H    . THR A 1 201 ? 2.97615   10.79705 12.41812  1.000 19.67253  ? 201 THR A H    1 
ATOM   3031 H HA   . THR A 1 201 ? 2.92464   9.57006  14.71509  1.000 20.71926  ? 201 THR A HA   1 
ATOM   3032 H HB   . THR A 1 201 ? 5.19377   9.85075  12.95058  1.000 23.88045  ? 201 THR A HB   1 
ATOM   3033 H HG1  . THR A 1 201 ? 3.00706   8.49723  12.62661  1.000 24.27067  ? 201 THR A HG1  1 
ATOM   3034 H HG21 . THR A 1 201 ? 5.89188   7.78017  13.85148  1.000 26.93150  ? 201 THR A HG21 1 
ATOM   3035 H HG22 . THR A 1 201 ? 5.87369   8.91143  14.95258  1.000 26.93150  ? 201 THR A HG22 1 
ATOM   3036 H HG23 . THR A 1 201 ? 4.70637   7.85022  14.89175  1.000 26.93150  ? 201 THR A HG23 1 
ATOM   3037 N N    . VAL A 1 202 ? 4.92219   12.08311 14.72350  1.000 16.33076  ? 202 VAL A N    1 
ATOM   3038 C CA   . VAL A 1 202 ? 5.70794   12.91673 15.63242  1.000 17.44019  ? 202 VAL A CA   1 
ATOM   3039 C C    . VAL A 1 202 ? 4.80404   13.48344 16.73857  1.000 12.98870  ? 202 VAL A C    1 
ATOM   3040 O O    . VAL A 1 202 ? 5.23719   13.64715 17.87302  1.000 15.10701  ? 202 VAL A O    1 
ATOM   3041 C CB   . VAL A 1 202 ? 6.49158   14.02270 14.87088  1.000 15.86690  ? 202 VAL A CB   1 
ATOM   3042 C CG1  . VAL A 1 202 ? 5.54675   15.01442 14.20805  1.000 20.84094  ? 202 VAL A CG1  1 
ATOM   3043 C CG2  . VAL A 1 202 ? 7.47812   14.69573 15.82538  1.000 20.58535  ? 202 VAL A CG2  1 
ATOM   3044 H H    . VAL A 1 202 ? 4.92409   12.34220 13.90346  1.000 19.59691  ? 202 VAL A H    1 
ATOM   3045 H HA   . VAL A 1 202 ? 6.38280   12.35978 16.05107  1.000 20.92823  ? 202 VAL A HA   1 
ATOM   3046 H HB   . VAL A 1 202 ? 7.00299   13.62494 14.14898  1.000 19.04028  ? 202 VAL A HB   1 
ATOM   3047 H HG11 . VAL A 1 202 ? 6.06948   15.68395 13.73967  1.000 25.00912  ? 202 VAL A HG11 1 
ATOM   3048 H HG12 . VAL A 1 202 ? 4.97946   14.53933 13.58086  1.000 25.00912  ? 202 VAL A HG12 1 
ATOM   3049 H HG13 . VAL A 1 202 ? 5.00306   15.43743 14.89096  1.000 25.00912  ? 202 VAL A HG13 1 
ATOM   3050 H HG21 . VAL A 1 202 ? 8.11769   15.20955 15.30785  1.000 24.70242  ? 202 VAL A HG21 1 
ATOM   3051 H HG22 . VAL A 1 202 ? 6.98889   15.28237 16.42320  1.000 24.70242  ? 202 VAL A HG22 1 
ATOM   3052 H HG23 . VAL A 1 202 ? 7.93914   14.01232 16.33658  1.000 24.70242  ? 202 VAL A HG23 1 
ATOM   3053 N N    . ASN A 1 203 ? 3.54664   13.80449 16.40927  1.000 14.91873  ? 203 ASN A N    1 
ATOM   3054 C CA   . ASN A 1 203 ? 2.62736   14.32909 17.40548  1.000 15.09955  ? 203 ASN A CA   1 
ATOM   3055 C C    . ASN A 1 203 ? 2.19840   13.25870 18.39024  1.000 13.70527  ? 203 ASN A C    1 
ATOM   3056 O O    . ASN A 1 203 ? 2.06866   13.55397 19.59768  1.000 14.17870  ? 203 ASN A O    1 
ATOM   3057 C CB   . ASN A 1 203 ? 1.39443   14.90181 16.69899  1.000 16.43902  ? 203 ASN A CB   1 
ATOM   3058 C CG   . ASN A 1 203 ? 1.67928   16.21154 15.95232  1.000 14.39127  ? 203 ASN A CG   1 
ATOM   3059 O OD1  . ASN A 1 203 ? 2.81115   16.66236 15.88728  1.000 14.95881  ? 203 ASN A OD1  1 
ATOM   3060 N ND2  . ASN A 1 203 ? 0.61136   16.79970 15.36361  1.000 15.31369  ? 203 ASN A ND2  1 
ATOM   3061 H H    . ASN A 1 203 ? 3.21029   13.72643 15.62163  1.000 17.90247  ? 203 ASN A H    1 
ATOM   3062 H HA   . ASN A 1 203 ? 3.07281   15.03377 17.90136  1.000 18.11946  ? 203 ASN A HA   1 
ATOM   3063 H HB2  . ASN A 1 203 ? 1.07335   14.25392 16.05242  1.000 19.72683  ? 203 ASN A HB2  1 
ATOM   3064 H HB3  . ASN A 1 203 ? 0.70726   15.07913 17.36025  1.000 19.72683  ? 203 ASN A HB3  1 
ATOM   3065 H HD21 . ASN A 1 203 ? 0.71045   17.53621 14.93078  1.000 18.37643  ? 203 ASN A HD21 1 
ATOM   3066 H HD22 . ASN A 1 203 ? -0.16610  16.43680 15.42247  1.000 18.37643  ? 203 ASN A HD22 1 
ATOM   3067 N N    . VAL A 1 204 ? 1.97531   12.02635 17.94640  1.000 13.92817  ? 204 VAL A N    1 
ATOM   3068 C CA   . VAL A 1 204 ? 1.66576   10.96045 18.91399  1.000 14.90075  ? 204 VAL A CA   1 
ATOM   3069 C C    . VAL A 1 204 ? 2.81309   10.80666 19.89162  1.000 14.89940  ? 204 VAL A C    1 
ATOM   3070 O O    . VAL A 1 204 ? 2.59754   10.72184 21.10348  1.000 14.64097  ? 204 VAL A O    1 
ATOM   3071 C CB   . VAL A 1 204 ? 1.38189   9.63216  18.20313  1.000 13.29683  ? 204 VAL A CB   1 
ATOM   3072 C CG1  . VAL A 1 204 ? 1.14448   8.51924  19.22464  1.000 14.27334  ? 204 VAL A CG1  1 
ATOM   3073 C CG2  . VAL A 1 204 ? 0.12818   9.76625  17.30271  1.000 15.18152  ? 204 VAL A CG2  1 
ATOM   3074 H H    . VAL A 1 204 ? 1.99462   11.78209 17.12204  1.000 16.71380  ? 204 VAL A H    1 
ATOM   3075 H HA   . VAL A 1 204 ? 0.86402   11.21694 19.39599  1.000 17.88090  ? 204 VAL A HA   1 
ATOM   3076 H HB   . VAL A 1 204 ? 2.15000   9.40399  17.65646  1.000 15.95620  ? 204 VAL A HB   1 
ATOM   3077 H HG11 . VAL A 1 204 ? 0.52582   8.83763  19.90049  1.000 17.12800  ? 204 VAL A HG11 1 
ATOM   3078 H HG12 . VAL A 1 204 ? 0.77010   7.74825  18.77040  1.000 17.12800  ? 204 VAL A HG12 1 
ATOM   3079 H HG13 . VAL A 1 204 ? 1.99044   8.28232  19.63588  1.000 17.12800  ? 204 VAL A HG13 1 
ATOM   3080 H HG21 . VAL A 1 204 ? -0.10255  8.89242  16.95044  1.000 18.21782  ? 204 VAL A HG21 1 
ATOM   3081 H HG22 . VAL A 1 204 ? -0.60596  10.11342 17.83319  1.000 18.21782  ? 204 VAL A HG22 1 
ATOM   3082 H HG23 . VAL A 1 204 ? 0.32644   10.37489 16.57390  1.000 18.21782  ? 204 VAL A HG23 1 
ATOM   3083 N N    . LEU A 1 205 ? 4.05389   10.83225 19.39697  1.000 14.17898  ? 205 LEU A N    1 
ATOM   3084 C CA   . LEU A 1 205 ? 5.20268   10.74306 20.27572  1.000 17.46878  ? 205 LEU A CA   1 
ATOM   3085 C C    . LEU A 1 205 ? 5.22997   11.90430 21.26507  1.000 15.67142  ? 205 LEU A C    1 
ATOM   3086 O O    . LEU A 1 205 ? 5.44917   11.70686 22.44904  1.000 15.45251  ? 205 LEU A O    1 
ATOM   3087 C CB   . LEU A 1 205 ? 6.49221   10.67841 19.45840  1.000 16.61080  ? 205 LEU A CB   1 
ATOM   3088 C CG   . LEU A 1 205 ? 6.64307   9.36132  18.74914  1.000 16.84954  ? 205 LEU A CG   1 
ATOM   3089 C CD1  . LEU A 1 205 ? 7.79258   9.49719  17.73759  1.000 18.44838  ? 205 LEU A CD1  1 
ATOM   3090 C CD2  . LEU A 1 205 ? 6.91633   8.19460  19.68355  1.000 21.14012  ? 205 LEU A CD2  1 
ATOM   3091 H H    . LEU A 1 205 ? 4.24870   10.90021 18.56209  1.000 17.01477  ? 205 LEU A H    1 
ATOM   3092 H HA   . LEU A 1 205 ? 5.14478   9.92140  20.78800  1.000 20.96254  ? 205 LEU A HA   1 
ATOM   3093 H HB2  . LEU A 1 205 ? 6.48228   11.38342 18.79225  1.000 19.93296  ? 205 LEU A HB2  1 
ATOM   3094 H HB3  . LEU A 1 205 ? 7.25096   10.79324 20.05171  1.000 19.93296  ? 205 LEU A HB3  1 
ATOM   3095 H HG   . LEU A 1 205 ? 5.80420   9.15267  18.30908  1.000 20.21945  ? 205 LEU A HG   1 
ATOM   3096 H HD11 . LEU A 1 205 ? 7.48878   10.02630 16.98351  1.000 22.13805  ? 205 LEU A HD11 1 
ATOM   3097 H HD12 . LEU A 1 205 ? 8.54251   9.93598  18.16883  1.000 22.13805  ? 205 LEU A HD12 1 
ATOM   3098 H HD13 . LEU A 1 205 ? 8.05491   8.61303  17.43702  1.000 22.13805  ? 205 LEU A HD13 1 
ATOM   3099 H HD21 . LEU A 1 205 ? 7.21286   7.43362  19.16022  1.000 25.36815  ? 205 LEU A HD21 1 
ATOM   3100 H HD22 . LEU A 1 205 ? 7.60650   8.45080  20.31516  1.000 25.36815  ? 205 LEU A HD22 1 
ATOM   3101 H HD23 . LEU A 1 205 ? 6.10002   7.97197  20.15785  1.000 25.36815  ? 205 LEU A HD23 1 
ATOM   3102 N N    . ALA A 1 206 ? 4.94988   13.12124 20.80322  1.000 13.56308  ? 206 ALA A N    1 
ATOM   3103 C CA   . ALA A 1 206 ? 4.93588   14.26233 21.70408  1.000 16.97185  ? 206 ALA A CA   1 
ATOM   3104 C C    . ALA A 1 206 ? 3.90737   14.06720 22.80847  1.000 15.64198  ? 206 ALA A C    1 
ATOM   3105 O O    . ALA A 1 206 ? 4.17454   14.40492 23.95272  1.000 16.41566  ? 206 ALA A O    1 
ATOM   3106 C CB   . ALA A 1 206 ? 4.64362   15.54039 20.92069  1.000 15.24780  ? 206 ALA A CB   1 
ATOM   3107 H H    . ALA A 1 206 ? 4.76738   13.30799 19.98382  1.000 16.27570  ? 206 ALA A H    1 
ATOM   3108 H HA   . ALA A 1 206 ? 5.81000   14.35444 22.11435  1.000 20.36622  ? 206 ALA A HA   1 
ATOM   3109 H HB1  . ALA A 1 206 ? 4.71448   16.30066 21.51892  1.000 18.29736  ? 206 ALA A HB1  1 
ATOM   3110 H HB2  . ALA A 1 206 ? 5.28881   15.62433 20.20125  1.000 18.29736  ? 206 ALA A HB2  1 
ATOM   3111 H HB3  . ALA A 1 206 ? 3.74628   15.48900 20.55594  1.000 18.29736  ? 206 ALA A HB3  1 
ATOM   3112 N N    . TRP A 1 207 ? 2.72632   13.59387 22.45670  1.000 12.33478  ? 207 TRP A N    1 
ATOM   3113 C CA   . TRP A 1 207 ? 1.66051   13.37688 23.41742  1.000 15.47944  ? 207 TRP A CA   1 
ATOM   3114 C C    . TRP A 1 207 ? 2.03375   12.26758 24.41024  1.000 16.21530  ? 207 TRP A C    1 
ATOM   3115 O O    . TRP A 1 207 ? 1.75266   12.39406 25.61157  1.000 15.44785  ? 207 TRP A O    1 
ATOM   3116 C CB   . TRP A 1 207 ? 0.40970   13.05127 22.66649  1.000 16.75121  ? 207 TRP A CB   1 
ATOM   3117 C CG   . TRP A 1 207 ? -0.77875  12.60127 23.43596  1.000 16.19474  ? 207 TRP A CG   1 
ATOM   3118 C CD1  . TRP A 1 207 ? -1.66876  13.39601 24.11199  1.000 17.95765  ? 207 TRP A CD1  1 
ATOM   3119 C CD2  . TRP A 1 207 ? -1.26230  11.26974 23.52077  1.000 14.51475  ? 207 TRP A CD2  1 
ATOM   3120 N NE1  . TRP A 1 207 ? -2.68042  12.60554 24.61397  1.000 20.07207  ? 207 TRP A NE1  1 
ATOM   3121 C CE2  . TRP A 1 207 ? -2.46007  11.30687 24.26942  1.000 17.02691  ? 207 TRP A CE2  1 
ATOM   3122 C CE3  . TRP A 1 207 ? -0.82360  10.04279 23.01189  1.000 17.86352  ? 207 TRP A CE3  1 
ATOM   3123 C CZ2  . TRP A 1 207 ? -3.18115  10.16211 24.53939  1.000 19.32758  ? 207 TRP A CZ2  1 
ATOM   3124 C CZ3  . TRP A 1 207 ? -1.53328  8.91824  23.32233  1.000 21.83885  ? 207 TRP A CZ3  1 
ATOM   3125 C CH2  . TRP A 1 207 ? -2.69450  8.99338  24.07986  1.000 19.29627  ? 207 TRP A CH2  1 
ATOM   3126 H H    . TRP A 1 207 ? 2.50939   13.38510 21.65112  1.000 14.80174  ? 207 TRP A H    1 
ATOM   3127 H HA   . TRP A 1 207 ? 1.50287   14.17942 23.93894  1.000 18.57532  ? 207 TRP A HA   1 
ATOM   3128 H HB2  . TRP A 1 207 ? 0.14050   13.84862 22.18413  1.000 20.10146  ? 207 TRP A HB2  1 
ATOM   3129 H HB3  . TRP A 1 207 ? 0.61910   12.34001 22.04107  1.000 20.10146  ? 207 TRP A HB3  1 
ATOM   3130 H HD1  . TRP A 1 207 ? -1.60088  14.31779 24.21497  1.000 21.54918  ? 207 TRP A HD1  1 
ATOM   3131 H HE1  . TRP A 1 207 ? -3.34888  12.88943 25.07459  1.000 24.08648  ? 207 TRP A HE1  1 
ATOM   3132 H HE3  . TRP A 1 207 ? -0.06609  9.99410  22.47456  1.000 21.43622  ? 207 TRP A HE3  1 
ATOM   3133 H HZ2  . TRP A 1 207 ? -3.97550  10.19626 25.02183  1.000 23.19309  ? 207 TRP A HZ2  1 
ATOM   3134 H HZ3  . TRP A 1 207 ? -1.23460  8.09026  23.02210  1.000 26.20662  ? 207 TRP A HZ3  1 
ATOM   3135 H HH2  . TRP A 1 207 ? -3.15270  8.20847  24.27701  1.000 23.15553  ? 207 TRP A HH2  1 
ATOM   3136 N N    . LEU A 1 208 ? 2.73975   11.24507 23.95827  1.000 13.93132  ? 208 LEU A N    1 
ATOM   3137 C CA   . LEU A 1 208 ? 3.26104   10.24410 24.91025  1.000 15.07258  ? 208 LEU A CA   1 
ATOM   3138 C C    . LEU A 1 208 ? 4.23556   10.87194 25.89516  1.000 15.48848  ? 208 LEU A C    1 
ATOM   3139 O O    . LEU A 1 208 ? 4.20930   10.56185 27.11248  1.000 15.66688  ? 208 LEU A O    1 
ATOM   3140 C CB   . LEU A 1 208 ? 3.90365   9.06010  24.16602  1.000 16.82522  ? 208 LEU A CB   1 
ATOM   3141 C CG   . LEU A 1 208 ? 2.93405   8.15908  23.39548  1.000 16.86804  ? 208 LEU A CG   1 
ATOM   3142 C CD1  . LEU A 1 208 ? 3.74388   7.16506  22.57066  1.000 17.93580  ? 208 LEU A CD1  1 
ATOM   3143 C CD2  . LEU A 1 208 ? 1.92830   7.41304  24.27430  1.000 16.89407  ? 208 LEU A CD2  1 
ATOM   3144 H H    . LEU A 1 208 ? 2.93256   11.10014 23.13279  1.000 16.71758  ? 208 LEU A H    1 
ATOM   3145 H HA   . LEU A 1 208 ? 2.51556   9.88755  25.41821  1.000 18.08710  ? 208 LEU A HA   1 
ATOM   3146 H HB2  . LEU A 1 208 ? 4.54098   9.41322  23.52569  1.000 20.19026  ? 208 LEU A HB2  1 
ATOM   3147 H HB3  . LEU A 1 208 ? 4.36031   8.50386  24.81637  1.000 20.19026  ? 208 LEU A HB3  1 
ATOM   3148 H HG   . LEU A 1 208 ? 2.39536   8.73144  22.82704  1.000 20.24165  ? 208 LEU A HG   1 
ATOM   3149 H HD11 . LEU A 1 208 ? 4.62528   7.07175  22.96478  1.000 21.52296  ? 208 LEU A HD11 1 
ATOM   3150 H HD12 . LEU A 1 208 ? 3.28854   6.30857  22.57207  1.000 21.52296  ? 208 LEU A HD12 1 
ATOM   3151 H HD13 . LEU A 1 208 ? 3.82107   7.49713  21.66255  1.000 21.52296  ? 208 LEU A HD13 1 
ATOM   3152 H HD21 . LEU A 1 208 ? 1.53612   8.03704  24.90494  1.000 20.27289  ? 208 LEU A HD21 1 
ATOM   3153 H HD22 . LEU A 1 208 ? 1.23621   7.03397  23.71020  1.000 20.27289  ? 208 LEU A HD22 1 
ATOM   3154 H HD23 . LEU A 1 208 ? 2.38975   6.70609  24.75200  1.000 20.27289  ? 208 LEU A HD23 1 
ATOM   3155 N N    . TYR A 1 209 ? 5.08496   11.79784 25.45579  1.000 15.53363  ? 209 TYR A N    1 
ATOM   3156 C CA   . TYR A 1 209 ? 5.95230   12.52253 26.37482  1.000 18.61526  ? 209 TYR A CA   1 
ATOM   3157 C C    . TYR A 1 209 ? 5.14591   13.38206 27.34590  1.000 18.10128  ? 209 TYR A C    1 
ATOM   3158 O O    . TYR A 1 209 ? 5.44300   13.42827 28.55030  1.000 16.13575  ? 209 TYR A O    1 
ATOM   3159 C CB   . TYR A 1 209 ? 6.97321   13.36886 25.62040  1.000 16.09836  ? 209 TYR A CB   1 
ATOM   3160 C CG   . TYR A 1 209 ? 8.16325   12.62523 25.10713  1.000 16.68902  ? 209 TYR A CG   1 
ATOM   3161 C CD1  . TYR A 1 209 ? 9.15611   12.18448 25.98894  1.000 19.54592  ? 209 TYR A CD1  1 
ATOM   3162 C CD2  . TYR A 1 209 ? 8.31573   12.34644 23.76373  1.000 18.31660  ? 209 TYR A CD2  1 
ATOM   3163 C CE1  . TYR A 1 209 ? 10.26173  11.50362 25.52508  1.000 19.73137  ? 209 TYR A CE1  1 
ATOM   3164 C CE2  . TYR A 1 209 ? 9.42051   11.65788 23.28344  1.000 21.50539  ? 209 TYR A CE2  1 
ATOM   3165 C CZ   . TYR A 1 209 ? 10.38996  11.23845 24.18512  1.000 21.86935  ? 209 TYR A CZ   1 
ATOM   3166 O OH   . TYR A 1 209 ? 11.48944  10.53951 23.72971  1.000 22.40658  ? 209 TYR A OH   1 
ATOM   3167 H H    . TYR A 1 209 ? 5.17787   12.02443 24.63140  1.000 18.64035  ? 209 TYR A H    1 
ATOM   3168 H HA   . TYR A 1 209 ? 6.44941   11.86974 26.89218  1.000 22.33831  ? 209 TYR A HA   1 
ATOM   3169 H HB2  . TYR A 1 209 ? 6.53186   13.77187 24.85641  1.000 19.31804  ? 209 TYR A HB2  1 
ATOM   3170 H HB3  . TYR A 1 209 ? 7.29912   14.05998 26.21792  1.000 19.31804  ? 209 TYR A HB3  1 
ATOM   3171 H HD1  . TYR A 1 209 ? 9.06923   12.35288 26.89943  1.000 23.45511  ? 209 TYR A HD1  1 
ATOM   3172 H HD2  . TYR A 1 209 ? 7.66142   12.62723 23.16546  1.000 21.97992  ? 209 TYR A HD2  1 
ATOM   3173 H HE1  . TYR A 1 209 ? 10.91986  11.22443 26.11990  1.000 23.67764  ? 209 TYR A HE1  1 
ATOM   3174 H HE2  . TYR A 1 209 ? 9.51010   11.48060 22.37490  1.000 25.80647  ? 209 TYR A HE2  1 
ATOM   3175 H HH   . TYR A 1 209 ? 11.67453  10.77477 22.94485  1.000 26.88790  ? 209 TYR A HH   1 
ATOM   3176 N N    . ALA A 1 210 ? 4.07285   14.03694 26.85833  1.000 16.65906  ? 210 ALA A N    1 
ATOM   3177 C CA   . ALA A 1 210 ? 3.19947   14.79447 27.73993  1.000 17.30550  ? 210 ALA A CA   1 
ATOM   3178 C C    . ALA A 1 210 ? 2.60293   13.87390 28.79682  1.000 15.13025  ? 210 ALA A C    1 
ATOM   3179 O O    . ALA A 1 210 ? 2.47158   14.26320 29.96902  1.000 17.38977  ? 210 ALA A O    1 
ATOM   3180 C CB   . ALA A 1 210 ? 2.05993   15.40954 26.95954  1.000 15.63527  ? 210 ALA A CB   1 
ATOM   3181 H H    . ALA A 1 210 ? 3.84109   14.05145 26.03028  1.000 19.99087  ? 210 ALA A H    1 
ATOM   3182 H HA   . ALA A 1 210 ? 3.71878   15.50224 28.15258  1.000 20.76660  ? 210 ALA A HA   1 
ATOM   3183 H HB1  . ALA A 1 210 ? 1.55964   16.00039 27.54393  1.000 18.76233  ? 210 ALA A HB1  1 
ATOM   3184 H HB2  . ALA A 1 210 ? 2.42305   15.91191 26.21344  1.000 18.76233  ? 210 ALA A HB2  1 
ATOM   3185 H HB3  . ALA A 1 210 ? 1.48304   14.70175 26.63224  1.000 18.76233  ? 210 ALA A HB3  1 
ATOM   3186 N N    . ALA A 1 211 ? 2.27727   12.64405 28.41680  1.000 15.19973  ? 211 ALA A N    1 
ATOM   3187 C CA   . ALA A 1 211 ? 1.68029   11.70292 29.34635  1.000 17.74508  ? 211 ALA A CA   1 
ATOM   3188 C C    . ALA A 1 211 ? 2.68222   11.36467 30.43695  1.000 17.74936  ? 211 ALA A C    1 
ATOM   3189 O O    . ALA A 1 211 ? 2.35441   11.36938 31.62733  1.000 18.67345  ? 211 ALA A O    1 
ATOM   3190 C CB   . ALA A 1 211 ? 1.26350   10.44045 28.62971  1.000 17.03433  ? 211 ALA A CB   1 
ATOM   3191 H H    . ALA A 1 211 ? 2.39263   12.33086 27.62420  1.000 18.23968  ? 211 ALA A H    1 
ATOM   3192 H HA   . ALA A 1 211 ? 0.88557   12.10009 29.73569  1.000 21.29410  ? 211 ALA A HA   1 
ATOM   3193 H HB1  . ALA A 1 211 ? 0.78810   9.86693  29.25099  1.000 20.44120  ? 211 ALA A HB1  1 
ATOM   3194 H HB2  . ALA A 1 211 ? 0.68507   10.67507 27.88724  1.000 20.44120  ? 211 ALA A HB2  1 
ATOM   3195 H HB3  . ALA A 1 211 ? 2.05588   9.98742  28.30139  1.000 20.44120  ? 211 ALA A HB3  1 
ATOM   3196 N N    . VAL A 1 212 ? 3.92747   11.09935 30.05757  1.000 14.74873  ? 212 VAL A N    1 
ATOM   3197 C CA   . VAL A 1 212 ? 4.96450   10.79055 31.04775  1.000 22.80434  ? 212 VAL A CA   1 
ATOM   3198 C C    . VAL A 1 212 ? 5.17446   11.97430 31.98253  1.000 19.00506  ? 212 VAL A C    1 
ATOM   3199 O O    . VAL A 1 212 ? 5.26647   11.81100 33.20855  1.000 21.14546  ? 212 VAL A O    1 
ATOM   3200 C CB   . VAL A 1 212 ? 6.27255   10.37788 30.34122  1.000 23.10324  ? 212 VAL A CB   1 
ATOM   3201 C CG1  . VAL A 1 212 ? 7.43124   10.29498 31.34337  1.000 21.51495  ? 212 VAL A CG1  1 
ATOM   3202 C CG2  . VAL A 1 212 ? 6.09788   9.06066  29.61363  1.000 23.04283  ? 212 VAL A CG2  1 
ATOM   3203 H H    . VAL A 1 212 ? 4.20045   11.09044 29.24209  1.000 17.69848  ? 212 VAL A H    1 
ATOM   3204 H HA   . VAL A 1 212 ? 4.66727   10.04025 31.58590  1.000 27.36521  ? 212 VAL A HA   1 
ATOM   3205 H HB   . VAL A 1 212 ? 6.49402   11.05608 29.68403  1.000 27.72389  ? 212 VAL A HB   1 
ATOM   3206 H HG11 . VAL A 1 212 ? 8.20285   9.90616  30.90253  1.000 25.81794  ? 212 VAL A HG11 1 
ATOM   3207 H HG12 . VAL A 1 212 ? 7.64378   11.18863 31.65502  1.000 25.81794  ? 212 VAL A HG12 1 
ATOM   3208 H HG13 . VAL A 1 212 ? 7.16261   9.73896  32.09143  1.000 25.81794  ? 212 VAL A HG13 1 
ATOM   3209 H HG21 . VAL A 1 212 ? 6.95097   8.79153  29.23853  1.000 27.65139  ? 212 VAL A HG21 1 
ATOM   3210 H HG22 . VAL A 1 212 ? 5.78722   8.39105  30.24292  1.000 27.65139  ? 212 VAL A HG22 1 
ATOM   3211 H HG23 . VAL A 1 212 ? 5.44620   9.17564  28.90440  1.000 27.65139  ? 212 VAL A HG23 1 
ATOM   3212 N N    . ILE A 1 213 ? 5.27639   13.19308 31.43761  1.000 17.41505  ? 213 ILE A N    1 
ATOM   3213 C CA   . ILE A 1 213 ? 5.43643   14.37245 32.28432  1.000 18.76881  ? 213 ILE A CA   1 
ATOM   3214 C C    . ILE A 1 213 ? 4.30793   14.47665 33.29781  1.000 20.97323  ? 213 ILE A C    1 
ATOM   3215 O O    . ILE A 1 213 ? 4.52556   14.93878 34.44712  1.000 23.47665  ? 213 ILE A O    1 
ATOM   3216 C CB   . ILE A 1 213 ? 5.57844   15.62905 31.40129  1.000 20.99724  ? 213 ILE A CB   1 
ATOM   3217 C CG1  . ILE A 1 213 ? 6.87440   15.55576 30.60261  1.000 19.62207  ? 213 ILE A CG1  1 
ATOM   3218 C CG2  . ILE A 1 213 ? 5.49014   16.88580 32.25688  1.000 21.71496  ? 213 ILE A CG2  1 
ATOM   3219 C CD1  . ILE A 1 213 ? 6.97351   16.53220 29.46921  1.000 25.85568  ? 213 ILE A CD1  1 
ATOM   3220 H H    . ILE A 1 213 ? 5.25579   13.35821 30.59386  1.000 20.89806  ? 213 ILE A H    1 
ATOM   3221 H HA   . ILE A 1 213 ? 6.25406   14.28799 32.79933  1.000 22.52257  ? 213 ILE A HA   1 
ATOM   3222 H HB   . ILE A 1 213 ? 4.84724   15.66517 30.76495  1.000 25.19668  ? 213 ILE A HB   1 
ATOM   3223 H HG12 . ILE A 1 213 ? 7.61590   15.73044 31.20308  1.000 23.54649  ? 213 ILE A HG12 1 
ATOM   3224 H HG13 . ILE A 1 213 ? 6.95424   14.66491 30.22724  1.000 23.54649  ? 213 ILE A HG13 1 
ATOM   3225 H HG21 . ILE A 1 213 ? 5.87365   17.62948 31.76621  1.000 26.05795  ? 213 ILE A HG21 1 
ATOM   3226 H HG22 . ILE A 1 213 ? 4.55841   17.06683 32.45692  1.000 26.05795  ? 213 ILE A HG22 1 
ATOM   3227 H HG23 . ILE A 1 213 ? 5.98341   16.74292 33.07978  1.000 26.05795  ? 213 ILE A HG23 1 
ATOM   3228 H HD11 . ILE A 1 213 ? 7.72296   16.28589 28.90480  1.000 31.02682  ? 213 ILE A HD11 1 
ATOM   3229 H HD12 . ILE A 1 213 ? 6.15051   16.50553 28.95652  1.000 31.02682  ? 213 ILE A HD12 1 
ATOM   3230 H HD13 . ILE A 1 213 ? 7.10970   17.42220 29.83012  1.000 31.02682  ? 213 ILE A HD13 1 
ATOM   3231 N N    . ASN A 1 214 ? 3.12425   14.00402 32.94507  1.000 18.84133  ? 214 ASN A N    1 
ATOM   3232 C CA   . ASN A 1 214 ? 1.95129   14.07810 33.78967  1.000 22.85739  ? 214 ASN A CA   1 
ATOM   3233 C C    . ASN A 1 214 ? 1.69294   12.80930 34.59805  1.000 27.88355  ? 214 ASN A C    1 
ATOM   3234 O O    . ASN A 1 214 ? 0.61364   12.67284 35.18390  1.000 28.77642  ? 214 ASN A O    1 
ATOM   3235 C CB   . ASN A 1 214 ? 0.72701   14.44932 32.96038  1.000 23.60015  ? 214 ASN A CB   1 
ATOM   3236 C CG   . ASN A 1 214 ? 0.66213   15.93149 32.71162  1.000 30.52848  ? 214 ASN A CG   1 
ATOM   3237 O OD1  . ASN A 1 214 ? 0.11970   16.66497 33.52824  1.000 31.20101  ? 214 ASN A OD1  1 
ATOM   3238 N ND2  . ASN A 1 214 ? 1.25851   16.39334 31.61303  1.000 26.63525  ? 214 ASN A ND2  1 
ATOM   3239 H H    . ASN A 1 214 ? 2.97174   13.62095 32.19036  1.000 22.60959  ? 214 ASN A H    1 
ATOM   3240 H HA   . ASN A 1 214 ? 2.09513   14.78768 34.43520  1.000 27.42886  ? 214 ASN A HA   1 
ATOM   3241 H HB2  . ASN A 1 214 ? 0.77016   13.99704 32.10337  1.000 28.32018  ? 214 ASN A HB2  1 
ATOM   3242 H HB3  . ASN A 1 214 ? -0.07573  14.18362 33.43568  1.000 28.32018  ? 214 ASN A HB3  1 
ATOM   3243 H HD21 . ASN A 1 214 ? 1.24283   17.23493 31.43673  1.000 31.96230  ? 214 ASN A HD21 1 
ATOM   3244 H HD22 . ASN A 1 214 ? 1.65905   15.84981 31.08037  1.000 31.96230  ? 214 ASN A HD22 1 
ATOM   3245 N N    . GLY A 1 215 ? 2.64114   11.87812 34.62201  1.000 22.53638  ? 215 GLY A N    1 
ATOM   3246 C CA   . GLY A 1 215 ? 2.56936   10.73139 35.50571  1.000 25.02727  ? 215 GLY A CA   1 
ATOM   3247 C C    . GLY A 1 215 ? 2.04737   9.44391  34.93165  1.000 23.33109  ? 215 GLY A C    1 
ATOM   3248 O O    . GLY A 1 215 ? 1.95840   8.45528  35.67351  1.000 27.48652  ? 215 GLY A O    1 
ATOM   3249 H H    . GLY A 1 215 ? 3.34420   11.89263 34.12693  1.000 27.04366  ? 215 GLY A H    1 
ATOM   3250 H HA2  . GLY A 1 215 ? 3.46282   10.55269 35.83843  1.000 30.03272  ? 215 GLY A HA2  1 
ATOM   3251 H HA3  . GLY A 1 215 ? 1.99495   10.96337 36.25212  1.000 30.03272  ? 215 GLY A HA3  1 
ATOM   3252 N N    . ASP A 1 216 ? 1.68838   9.38438  33.64061  1.000 19.38134  ? 216 ASP A N    1 
ATOM   3253 C CA   . ASP A 1 216 ? 1.28143   8.14924  33.02704  1.000 21.92049  ? 216 ASP A CA   1 
ATOM   3254 C C    . ASP A 1 216 ? 2.53791   7.47848  32.49150  1.000 25.04048  ? 216 ASP A C    1 
ATOM   3255 O O    . ASP A 1 216 ? 3.19781   8.02350  31.57745  1.000 25.70582  ? 216 ASP A O    1 
ATOM   3256 C CB   . ASP A 1 216 ? 0.30966   8.38501  31.85720  1.000 27.61038  ? 216 ASP A CB   1 
ATOM   3257 C CG   . ASP A 1 216 ? -1.10872  8.66601  32.31814  1.000 47.65199  ? 216 ASP A CG   1 
ATOM   3258 O OD1  . ASP A 1 216 ? -1.45929  8.25182  33.43796  1.000 54.95352  ? 216 ASP A OD1  1 
ATOM   3259 O OD2  . ASP A 1 216 ? -1.87479  9.29295  31.53618  1.000 33.54700  ? 216 ASP A OD2  1 
ATOM   3260 H H    . ASP A 1 216 ? 1.67788   10.06058 33.10933  1.000 23.25761  ? 216 ASP A H    1 
ATOM   3261 H HA   . ASP A 1 216 ? 0.83356   7.59444  33.68469  1.000 26.30459  ? 216 ASP A HA   1 
ATOM   3262 H HB2  . ASP A 1 216 ? 0.61433   9.14860  31.34241  1.000 33.13246  ? 216 ASP A HB2  1 
ATOM   3263 H HB3  . ASP A 1 216 ? 0.29148   7.59325  31.29713  1.000 33.13246  ? 216 ASP A HB3  1 
ATOM   3264 N N    . ARG A 1 217 ? 2.86826   6.30547  33.04983  1.000 21.58623  ? 217 ARG A N    1 
ATOM   3265 C CA   . ARG A 1 217 ? 4.10932   5.61726  32.69235  1.000 18.36603  ? 217 ARG A CA   1 
ATOM   3266 C C    . ARG A 1 217 ? 3.90786   4.17000  32.31455  1.000 17.06361  ? 217 ARG A C    1 
ATOM   3267 O O    . ARG A 1 217 ? 4.88950   3.50468  32.01666  1.000 21.58868  ? 217 ARG A O    1 
ATOM   3268 C CB   . ARG A 1 217 ? 5.09378   5.64432  33.88603  1.000 21.53774  ? 217 ARG A CB   1 
ATOM   3269 C CG   . ARG A 1 217 ? 5.45180   7.03456  34.34948  1.000 23.37332  ? 217 ARG A CG   1 
ATOM   3270 C CD   . ARG A 1 217 ? 6.52279   6.97937  35.44180  1.000 22.31447  ? 217 ARG A CD   1 
ATOM   3271 N NE   . ARG A 1 217 ? 7.77575   6.40471  34.94790  1.000 21.21188  ? 217 ARG A NE   1 
ATOM   3272 C CZ   . ARG A 1 217 ? 8.77927   7.10492  34.43878  1.000 22.99298  ? 217 ARG A CZ   1 
ATOM   3273 N NH1  . ARG A 1 217 ? 8.70369   8.42852  34.27436  1.000 20.55381  ? 217 ARG A NH1  1 
ATOM   3274 N NH2  . ARG A 1 217 ? 9.87173   6.46347  34.03603  1.000 21.01409  ? 217 ARG A NH2  1 
ATOM   3275 H H    . ARG A 1 217 ? 2.39071   5.89330  33.63435  1.000 25.90347  ? 217 ARG A H    1 
ATOM   3276 H HA   . ARG A 1 217 ? 4.50259   6.08483  31.93894  1.000 22.03923  ? 217 ARG A HA   1 
ATOM   3277 H HB2  . ARG A 1 217 ? 4.68905   5.17814  34.63421  1.000 25.84529  ? 217 ARG A HB2  1 
ATOM   3278 H HB3  . ARG A 1 217 ? 5.91470   5.19963  33.62290  1.000 25.84529  ? 217 ARG A HB3  1 
ATOM   3279 H HG2  . ARG A 1 217 ? 5.79913   7.54648  33.60236  1.000 28.04798  ? 217 ARG A HG2  1 
ATOM   3280 H HG3  . ARG A 1 217 ? 4.66380   7.46908  34.71161  1.000 28.04798  ? 217 ARG A HG3  1 
ATOM   3281 H HD2  . ARG A 1 217 ? 6.70463   7.87851  35.75705  1.000 26.77736  ? 217 ARG A HD2  1 
ATOM   3282 H HD3  . ARG A 1 217 ? 6.20434   6.42903  36.17434  1.000 26.77736  ? 217 ARG A HD3  1 
ATOM   3283 H HE   . ARG A 1 217 ? 7.86713   5.55069  34.99135  1.000 25.45426  ? 217 ARG A HE   1 
ATOM   3284 H HH11 . ARG A 1 217 ? 7.98919   8.84991  34.50134  1.000 24.66457  ? 217 ARG A HH11 1 
ATOM   3285 H HH12 . ARG A 1 217 ? 9.36954   8.85920  33.94155  1.000 24.66457  ? 217 ARG A HH12 1 
ATOM   3286 H HH21 . ARG A 1 217 ? 10.53116  6.90418  33.70357  1.000 25.21690  ? 217 ARG A HH21 1 
ATOM   3287 H HH22 . ARG A 1 217 ? 9.91906   5.60779  34.10794  1.000 25.21690  ? 217 ARG A HH22 1 
ATOM   3288 N N    . TRP A 1 218 ? 2.68844   3.65890  32.34734  1.000 19.75092  ? 218 TRP A N    1 
ATOM   3289 C CA   . TRP A 1 218 ? 2.47480   2.22384  32.21908  1.000 23.63482  ? 218 TRP A CA   1 
ATOM   3290 C C    . TRP A 1 218 ? 2.93693   1.67582  30.88329  1.000 23.73008  ? 218 TRP A C    1 
ATOM   3291 O O    . TRP A 1 218 ? 3.26564   0.48979  30.78217  1.000 24.03053  ? 218 TRP A O    1 
ATOM   3292 C CB   . TRP A 1 218 ? 1.01100   1.84415  32.46096  1.000 23.48316  ? 218 TRP A CB   1 
ATOM   3293 C CG   . TRP A 1 218 ? 0.00511   2.47248  31.48356  1.000 25.35881  ? 218 TRP A CG   1 
ATOM   3294 C CD1  . TRP A 1 218 ? -0.74956  3.58945  31.69659  1.000 23.70685  ? 218 TRP A CD1  1 
ATOM   3295 C CD2  . TRP A 1 218 ? -0.33413  1.97846  30.18941  1.000 22.97773  ? 218 TRP A CD2  1 
ATOM   3296 N NE1  . TRP A 1 218 ? -1.54853  3.82315  30.57884  1.000 26.75937  ? 218 TRP A NE1  1 
ATOM   3297 C CE2  . TRP A 1 218 ? -1.31403  2.85016  29.65420  1.000 22.69503  ? 218 TRP A CE2  1 
ATOM   3298 C CE3  . TRP A 1 218 ? 0.08134   0.88766  29.42980  1.000 25.35985  ? 218 TRP A CE3  1 
ATOM   3299 C CZ2  . TRP A 1 218 ? -1.86177  2.67000  28.38428  1.000 23.50320  ? 218 TRP A CZ2  1 
ATOM   3300 C CZ3  . TRP A 1 218 ? -0.47035  0.69808  28.16910  1.000 24.60316  ? 218 TRP A CZ3  1 
ATOM   3301 C CH2  . TRP A 1 218 ? -1.44743  1.59898  27.66522  1.000 24.46142  ? 218 TRP A CH2  1 
ATOM   3302 H H    . TRP A 1 218 ? 1.96707   4.11733  32.44251  1.000 23.70111  ? 218 TRP A H    1 
ATOM   3303 H HA   . TRP A 1 218 ? 3.00488   1.80323  32.91406  1.000 28.36179  ? 218 TRP A HA   1 
ATOM   3304 H HB2  . TRP A 1 218 ? 0.92722   0.88081  32.38444  1.000 28.17979  ? 218 TRP A HB2  1 
ATOM   3305 H HB3  . TRP A 1 218 ? 0.76387   2.12869  33.35476  1.000 28.17979  ? 218 TRP A HB3  1 
ATOM   3306 H HD1  . TRP A 1 218 ? -0.73325  4.11190  32.46579  1.000 28.44822  ? 218 TRP A HD1  1 
ATOM   3307 H HE1  . TRP A 1 218 ? -2.10058  4.47621  30.48743  1.000 32.11125  ? 218 TRP A HE1  1 
ATOM   3308 H HE3  . TRP A 1 218 ? 0.71767   0.29587  29.76112  1.000 30.43182  ? 218 TRP A HE3  1 
ATOM   3309 H HZ2  . TRP A 1 218 ? -2.48993  3.26468  28.04271  1.000 28.20384  ? 218 TRP A HZ2  1 
ATOM   3310 H HZ3  . TRP A 1 218 ? -0.19812  -0.02429 27.65047  1.000 29.52379  ? 218 TRP A HZ3  1 
ATOM   3311 H HH2  . TRP A 1 218 ? -1.81085  1.44983  26.82226  1.000 29.35370  ? 218 TRP A HH2  1 
ATOM   3312 N N    . PHE A 1 219 ? 2.97340   2.51676  29.82798  1.000 21.43527  ? 219 PHE A N    1 
ATOM   3313 C CA   . PHE A 1 219 ? 3.32718   2.04159  28.49705  1.000 19.19006  ? 219 PHE A CA   1 
ATOM   3314 C C    . PHE A 1 219 ? 4.82151   2.06645  28.24127  1.000 19.11894  ? 219 PHE A C    1 
ATOM   3315 O O    . PHE A 1 219 ? 5.26411   1.75019  27.12235  1.000 22.24018  ? 219 PHE A O    1 
ATOM   3316 C CB   . PHE A 1 219 ? 2.60805   2.94258  27.43566  1.000 22.64314  ? 219 PHE A CB   1 
ATOM   3317 C CG   . PHE A 1 219 ? 2.79009   4.40139  27.69010  1.000 17.75309  ? 219 PHE A CG   1 
ATOM   3318 C CD1  . PHE A 1 219 ? 3.91373   5.06097  27.25084  1.000 17.66090  ? 219 PHE A CD1  1 
ATOM   3319 C CD2  . PHE A 1 219 ? 1.83894   5.12306  28.40501  1.000 21.46525  ? 219 PHE A CD2  1 
ATOM   3320 C CE1  . PHE A 1 219 ? 4.11117   6.40736  27.51329  1.000 18.53460  ? 219 PHE A CE1  1 
ATOM   3321 C CE2  . PHE A 1 219 ? 2.03823   6.47123  28.65641  1.000 21.61539  ? 219 PHE A CE2  1 
ATOM   3322 C CZ   . PHE A 1 219 ? 3.17567   7.11187  28.22439  1.000 18.82092  ? 219 PHE A CZ   1 
ATOM   3323 H H    . PHE A 1 219 ? 2.79684   3.35740  29.86965  1.000 25.72232  ? 219 PHE A H    1 
ATOM   3324 H HA   . PHE A 1 219 ? 3.02732   1.12511  28.39199  1.000 23.02807  ? 219 PHE A HA   1 
ATOM   3325 H HB2  . PHE A 1 219 ? 2.96973   2.74449  26.55768  1.000 27.17177  ? 219 PHE A HB2  1 
ATOM   3326 H HB3  . PHE A 1 219 ? 1.65711   2.75206  27.45345  1.000 27.17177  ? 219 PHE A HB3  1 
ATOM   3327 H HD1  . PHE A 1 219 ? 4.55549   4.59319  26.76687  1.000 21.19308  ? 219 PHE A HD1  1 
ATOM   3328 H HD2  . PHE A 1 219 ? 1.07002   4.70086  28.71389  1.000 25.75830  ? 219 PHE A HD2  1 
ATOM   3329 H HE1  . PHE A 1 219 ? 4.87911   6.83290  27.20655  1.000 22.24152  ? 219 PHE A HE1  1 
ATOM   3330 H HE2  . PHE A 1 219 ? 1.39279   6.95002  29.12446  1.000 25.93846  ? 219 PHE A HE2  1 
ATOM   3331 H HZ   . PHE A 1 219 ? 3.30840   8.01288  28.41271  1.000 22.58510  ? 219 PHE A HZ   1 
ATOM   3332 N N    . LEU A 1 220 ? 5.61116   2.46896  29.20944  1.000 20.38220  ? 220 LEU A N    1 
ATOM   3333 C CA   . LEU A 1 220 ? 7.05569   2.51053  29.05031  1.000 18.87945  ? 220 LEU A CA   1 
ATOM   3334 C C    . LEU A 1 220 ? 7.63472   1.09252  29.14336  1.000 24.42460  ? 220 LEU A C    1 
ATOM   3335 O O    . LEU A 1 220 ? 7.03895   0.18983  29.72184  1.000 25.06710  ? 220 LEU A O    1 
ATOM   3336 C CB   . LEU A 1 220 ? 7.68259   3.42894  30.07094  1.000 22.20223  ? 220 LEU A CB   1 
ATOM   3337 C CG   . LEU A 1 220 ? 7.28986   4.91125  29.97677  1.000 20.99318  ? 220 LEU A CG   1 
ATOM   3338 C CD1  . LEU A 1 220 ? 7.92274   5.70807  31.09433  1.000 21.26756  ? 220 LEU A CD1  1 
ATOM   3339 C CD2  . LEU A 1 220 ? 7.66549   5.48212  28.59632  1.000 23.76820  ? 220 LEU A CD2  1 
ATOM   3340 H H    . LEU A 1 220 ? 5.33750   2.72844  29.98235  1.000 24.45864  ? 220 LEU A H    1 
ATOM   3341 H HA   . LEU A 1 220 ? 7.28337   2.86646  28.17717  1.000 22.65534  ? 220 LEU A HA   1 
ATOM   3342 H HB2  . LEU A 1 220 ? 7.42586   3.11965  30.95374  1.000 26.64268  ? 220 LEU A HB2  1 
ATOM   3343 H HB3  . LEU A 1 220 ? 8.64606   3.38041  29.96960  1.000 26.64268  ? 220 LEU A HB3  1 
ATOM   3344 H HG   . LEU A 1 220 ? 6.32828   4.99150  30.07584  1.000 25.19182  ? 220 LEU A HG   1 
ATOM   3345 H HD11 . LEU A 1 220 ? 7.80288   5.23030  31.92996  1.000 25.52107  ? 220 LEU A HD11 1 
ATOM   3346 H HD12 . LEU A 1 220 ? 8.86849   5.81691  30.90825  1.000 25.52107  ? 220 LEU A HD12 1 
ATOM   3347 H HD13 . LEU A 1 220 ? 7.49357   6.57647  31.14531  1.000 25.52107  ? 220 LEU A HD13 1 
ATOM   3348 H HD21 . LEU A 1 220 ? 7.09907   5.07581  27.92180  1.000 28.52185  ? 220 LEU A HD21 1 
ATOM   3349 H HD22 . LEU A 1 220 ? 7.53237   6.44290  28.60504  1.000 28.52185  ? 220 LEU A HD22 1 
ATOM   3350 H HD23 . LEU A 1 220 ? 8.59606   5.27876  28.41306  1.000 28.52185  ? 220 LEU A HD23 1 
ATOM   3351 N N    . ASN A 1 221 ? 8.80525   0.92310  28.54385  1.000 24.48525  ? 221 ASN A N    1 
ATOM   3352 C CA   . ASN A 1 221 ? 9.51182   -0.35409 28.58804  1.000 27.83825  ? 221 ASN A CA   1 
ATOM   3353 C C    . ASN A 1 221 ? 10.99980  -0.06837 28.51209  1.000 31.81916  ? 221 ASN A C    1 
ATOM   3354 O O    . ASN A 1 221 ? 11.42782  1.05100  28.23565  1.000 29.97138  ? 221 ASN A O    1 
ATOM   3355 C CB   . ASN A 1 221 ? 9.05530   -1.30433 27.48408  1.000 28.97058  ? 221 ASN A CB   1 
ATOM   3356 C CG   . ASN A 1 221 ? 8.96136   -0.63906 26.12132  1.000 49.85960  ? 221 ASN A CG   1 
ATOM   3357 O OD1  . ASN A 1 221 ? 7.86701   -0.40675 25.61663  1.000 45.91276  ? 221 ASN A OD1  1 
ATOM   3358 N ND2  . ASN A 1 221 ? 10.11261  -0.32216 25.52172  1.000 33.15803  ? 221 ASN A ND2  1 
ATOM   3359 H H    . ASN A 1 221 ? 9.21604   1.53545  28.10126  1.000 29.38230  ? 221 ASN A H    1 
ATOM   3360 H HA   . ASN A 1 221 ? 9.32843   -0.79809 29.43074  1.000 33.40590  ? 221 ASN A HA   1 
ATOM   3361 H HB2  . ASN A 1 221 ? 9.68990   -2.03476 27.41587  1.000 34.76469  ? 221 ASN A HB2  1 
ATOM   3362 H HB3  . ASN A 1 221 ? 8.17659   -1.64818 27.70891  1.000 34.76469  ? 221 ASN A HB3  1 
ATOM   3363 H HD21 . ASN A 1 221 ? 10.10533  0.05586  24.74929  1.000 39.78963  ? 221 ASN A HD21 1 
ATOM   3364 H HD22 . ASN A 1 221 ? 10.86089  -0.49621 25.90823  1.000 39.78963  ? 221 ASN A HD22 1 
ATOM   3365 N N    . ARG A 1 222 ? 11.79475  -1.10142 28.80267  1.000 36.46535  ? 222 ARG A N    1 
ATOM   3366 C CA   . ARG A 1 222 ? 13.24366  -0.99193 28.71198  1.000 43.16893  ? 222 ARG A CA   1 
ATOM   3367 C C    . ARG A 1 222 ? 13.74634  -1.21392 27.29280  1.000 36.21705  ? 222 ARG A C    1 
ATOM   3368 O O    . ARG A 1 222 ? 14.85880  -0.77949 26.97211  1.000 49.31337  ? 222 ARG A O    1 
ATOM   3369 C CB   . ARG A 1 222 ? 13.90743  -2.03794 29.61798  1.000 50.78673  ? 222 ARG A CB   1 
ATOM   3370 C CG   . ARG A 1 222 ? 14.00477  -3.41028 28.95602  1.000 65.79403  ? 222 ARG A CG   1 
ATOM   3371 C CD   . ARG A 1 222 ? 14.20559  -4.53922 29.95570  1.000 62.45978  ? 222 ARG A CD   1 
ATOM   3372 N NE   . ARG A 1 222 ? 14.33447  -5.82152 29.27045  1.000 73.13577  ? 222 ARG A NE   1 
ATOM   3373 C CZ   . ARG A 1 222 ? 13.31192  -6.54762 28.84087  1.000 74.03420  ? 222 ARG A CZ   1 
ATOM   3374 N NH1  . ARG A 1 222 ? 12.06187  -6.16801 29.04475  1.000 75.47639  ? 222 ARG A NH1  1 
ATOM   3375 N NH2  . ARG A 1 222 ? 13.54942  -7.68653 28.19314  1.000 80.06733  ? 222 ARG A NH2  1 
ATOM   3376 H H    . ARG A 1 222 ? 11.51561  -1.87493 29.05440  1.000 43.75842  ? 222 ARG A H    1 
ATOM   3377 H HA   . ARG A 1 222 ? 13.50464  -0.10647 29.00989  1.000 51.80271  ? 222 ARG A HA   1 
ATOM   3378 H HB2  . ARG A 1 222 ? 14.80598  -1.74390 29.83492  1.000 60.94407  ? 222 ARG A HB2  1 
ATOM   3379 H HB3  . ARG A 1 222 ? 13.38402  -2.13145 30.42927  1.000 60.94407  ? 222 ARG A HB3  1 
ATOM   3380 H HG2  . ARG A 1 222 ? 13.18403  -3.58490 28.46941  1.000 78.95283  ? 222 ARG A HG2  1 
ATOM   3381 H HG3  . ARG A 1 222 ? 14.75914  -3.41377 28.34625  1.000 78.95283  ? 222 ARG A HG3  1 
ATOM   3382 H HD2  . ARG A 1 222 ? 15.01512  -4.37983 30.46576  1.000 74.95174  ? 222 ARG A HD2  1 
ATOM   3383 H HD3  . ARG A 1 222 ? 13.44145  -4.58382 30.55152  1.000 74.95174  ? 222 ARG A HD3  1 
ATOM   3384 H HE   . ARG A 1 222 ? 15.12728  -6.12660 29.13633  1.000 87.76293  ? 222 ARG A HE   1 
ATOM   3385 H HH11 . ARG A 1 222 ? 11.89794  -5.43541 29.46430  1.000 90.57167  ? 222 ARG A HH11 1 
ATOM   3386 H HH12 . ARG A 1 222 ? 11.41275  -6.65371 28.75781  1.000 90.57167  ? 222 ARG A HH12 1 
ATOM   3387 H HH21 . ARG A 1 222 ? 14.35890  -7.94346 28.05773  1.000 96.08080  ? 222 ARG A HH21 1 
ATOM   3388 H HH22 . ARG A 1 222 ? 12.89333  -8.16518 27.91022  1.000 96.08080  ? 222 ARG A HH22 1 
ATOM   3389 N N    . PHE A 1 223 ? 12.95560  -1.87044 26.44797  1.000 38.20674  ? 223 PHE A N    1 
ATOM   3390 C CA   . PHE A 1 223 ? 13.35970  -2.15936 25.08249  1.000 42.20859  ? 223 PHE A CA   1 
ATOM   3391 C C    . PHE A 1 223 ? 13.53415  -0.86742 24.27569  1.000 48.36600  ? 223 PHE A C    1 
ATOM   3392 O O    . PHE A 1 223 ? 13.05856  0.21771  24.63894  1.000 35.53535  ? 223 PHE A O    1 
ATOM   3393 C CB   . PHE A 1 223 ? 12.31118  -3.05115 24.40493  1.000 43.20437  ? 223 PHE A CB   1 
ATOM   3394 H H    . PHE A 1 223 ? 12.17105  -2.16180 26.64593  1.000 45.84808  ? 223 PHE A H    1 
ATOM   3395 H HA   . PHE A 1 223 ? 14.21089  -2.62442 25.09186  1.000 50.65031  ? 223 PHE A HA   1 
ATOM   3396 N N    . THR A 1 224 ? 14.26291  -0.98623 23.17361  1.000 34.16437  ? 224 THR A N    1 
ATOM   3397 C CA   . THR A 1 224 ? 14.43134  0.09017  22.21855  1.000 40.64298  ? 224 THR A CA   1 
ATOM   3398 C C    . THR A 1 224 ? 14.17120  -0.45977 20.82006  1.000 36.96450  ? 224 THR A C    1 
ATOM   3399 O O    . THR A 1 224 ? 13.84476  -1.64097 20.64007  1.000 43.07043  ? 224 THR A O    1 
ATOM   3400 C CB   . THR A 1 224 ? 15.83088  0.69342  22.31089  1.000 43.95926  ? 224 THR A CB   1 
ATOM   3401 O OG1  . THR A 1 224 ? 15.86873  1.93304  21.59510  1.000 45.54849  ? 224 THR A OG1  1 
ATOM   3402 C CG2  . THR A 1 224 ? 16.86269  -0.26647 21.71383  1.000 42.70143  ? 224 THR A CG2  1 
ATOM   3403 H H    . THR A 1 224 ? 14.68101  -1.70498 22.95410  1.000 40.99725  ? 224 THR A H    1 
ATOM   3404 H HA   . THR A 1 224 ? 13.78686  0.79098  22.40407  1.000 48.77158  ? 224 THR A HA   1 
ATOM   3405 H HB   . THR A 1 224 ? 16.05631  0.85145  23.24100  1.000 52.75112  ? 224 THR A HB   1 
ATOM   3406 H HG1  . THR A 1 224 ? 15.53590  2.54563  22.06367  1.000 54.65819  ? 224 THR A HG1  1 
ATOM   3407 H HG21 . THR A 1 224 ? 17.74954  -0.04334 22.03728  1.000 51.24172  ? 224 THR A HG21 1 
ATOM   3408 H HG22 . THR A 1 224 ? 16.65446  -1.17859 21.96993  1.000 51.24172  ? 224 THR A HG22 1 
ATOM   3409 H HG23 . THR A 1 224 ? 16.85505  -0.20169 20.74603  1.000 51.24172  ? 224 THR A HG23 1 
ATOM   3410 N N    . THR A 1 225 ? 14.27896  0.41405  19.82974  1.000 33.14837  ? 225 THR A N    1 
ATOM   3411 C CA   . THR A 1 225 ? 14.12576  0.00578  18.44323  1.000 33.22275  ? 225 THR A CA   1 
ATOM   3412 C C    . THR A 1 225 ? 14.99047  0.89622  17.56357  1.000 34.04161  ? 225 THR A C    1 
ATOM   3413 O O    . THR A 1 225 ? 15.46768  1.95194  17.98035  1.000 32.36198  ? 225 THR A O    1 
ATOM   3414 C CB   . THR A 1 225 ? 12.65754  0.08667  17.98255  1.000 47.37019  ? 225 THR A CB   1 
ATOM   3415 O OG1  . THR A 1 225 ? 12.55256  -0.35018 16.61960  1.000 46.02424  ? 225 THR A OG1  1 
ATOM   3416 C CG2  . THR A 1 225 ? 12.14041  1.52137  18.06664  1.000 34.76895  ? 225 THR A CG2  1 
ATOM   3417 H H    . THR A 1 225 ? 14.44100  1.25197  19.93575  1.000 39.77805  ? 225 THR A H    1 
ATOM   3418 H HA   . THR A 1 225 ? 14.43060  -0.91133 18.36021  1.000 39.86730  ? 225 THR A HA   1 
ATOM   3419 H HB   . THR A 1 225 ? 12.11734  -0.47766 18.55754  1.000 56.84423  ? 225 THR A HB   1 
ATOM   3420 H HG1  . THR A 1 225 ? 11.75035  -0.32728 16.37154  1.000 55.22908  ? 225 THR A HG1  1 
ATOM   3421 H HG21 . THR A 1 225 ? 11.18005  1.53635  17.93109  1.000 41.72274  ? 225 THR A HG21 1 
ATOM   3422 H HG22 . THR A 1 225 ? 12.34113  1.89579  18.93866  1.000 41.72274  ? 225 THR A HG22 1 
ATOM   3423 H HG23 . THR A 1 225 ? 12.56309  2.06686  17.38496  1.000 41.72274  ? 225 THR A HG23 1 
ATOM   3424 N N    . THR A 1 226 ? 15.17925  0.45777  16.32637  1.000 30.73298  ? 226 THR A N    1 
ATOM   3425 C CA   . THR A 1 226 ? 15.83553  1.27123  15.31619  1.000 35.32888  ? 226 THR A CA   1 
ATOM   3426 C C    . THR A 1 226 ? 14.77839  2.12058  14.61018  1.000 29.42626  ? 226 THR A C    1 
ATOM   3427 O O    . THR A 1 226 ? 13.60061  1.74640  14.55592  1.000 28.82478  ? 226 THR A O    1 
ATOM   3428 C CB   . THR A 1 226 ? 16.55235  0.39374  14.28006  1.000 34.66077  ? 226 THR A CB   1 
ATOM   3429 O OG1  . THR A 1 226 ? 15.59650  -0.20984 13.39939  1.000 36.95604  ? 226 THR A OG1  1 
ATOM   3430 C CG2  . THR A 1 226 ? 17.32864  -0.72696 14.97297  1.000 41.19264  ? 226 THR A CG2  1 
ATOM   3431 H H    . THR A 1 226 ? 14.93294  -0.31670 16.04506  1.000 36.87957  ? 226 THR A H    1 
ATOM   3432 H HA   . THR A 1 226 ? 16.50100  1.84271  15.73027  1.000 42.39465  ? 226 THR A HA   1 
ATOM   3433 H HB   . THR A 1 226 ? 17.16611  0.94871  13.77390  1.000 41.59292  ? 226 THR A HB   1 
ATOM   3434 H HG1  . THR A 1 226 ? 15.99161  -0.67204 12.81986  1.000 44.34724  ? 226 THR A HG1  1 
ATOM   3435 H HG21 . THR A 1 226 ? 17.95471  -1.13028 14.35146  1.000 49.43116  ? 226 THR A HG21 1 
ATOM   3436 H HG22 . THR A 1 226 ? 17.82091  -0.37111 15.72924  1.000 49.43116  ? 226 THR A HG22 1 
ATOM   3437 H HG23 . THR A 1 226 ? 16.71552  -1.40887 15.28918  1.000 49.43116  ? 226 THR A HG23 1 
ATOM   3438 N N    . LEU A 1 227 ? 15.21654  3.26265  14.07979  1.000 26.97709  ? 227 LEU A N    1 
ATOM   3439 C CA   . LEU A 1 227 ? 14.33057  4.10413  13.28898  1.000 30.82674  ? 227 LEU A CA   1 
ATOM   3440 C C    . LEU A 1 227 ? 13.75087  3.34849  12.09897  1.000 40.40180  ? 227 LEU A C    1 
ATOM   3441 O O    . LEU A 1 227 ? 12.54831  3.44269  11.81537  1.000 27.70414  ? 227 LEU A O    1 
ATOM   3442 C CB   . LEU A 1 227 ? 15.09159  5.35537  12.85009  1.000 30.74591  ? 227 LEU A CB   1 
ATOM   3443 C CG   . LEU A 1 227 ? 14.28317  6.45355  12.16811  1.000 35.42929  ? 227 LEU A CG   1 
ATOM   3444 C CD1  . LEU A 1 227 ? 13.07679  6.84884  13.01018  1.000 36.70671  ? 227 LEU A CD1  1 
ATOM   3445 C CD2  . LEU A 1 227 ? 15.14885  7.66494  11.89265  1.000 35.59173  ? 227 LEU A CD2  1 
ATOM   3446 H H    . LEU A 1 227 ? 16.01604  3.56820  14.16368  1.000 32.37251  ? 227 LEU A H    1 
ATOM   3447 H HA   . LEU A 1 227 ? 13.57706  4.38482  13.83152  1.000 36.99208  ? 227 LEU A HA   1 
ATOM   3448 H HB2  . LEU A 1 227 ? 15.49658  5.75015  13.63815  1.000 36.89509  ? 227 LEU A HB2  1 
ATOM   3449 H HB3  . LEU A 1 227 ? 15.78071  5.08157  12.22475  1.000 36.89509  ? 227 LEU A HB3  1 
ATOM   3450 H HG   . LEU A 1 227 ? 13.95820  6.11161  11.32054  1.000 42.51515  ? 227 LEU A HG   1 
ATOM   3451 H HD11 . LEU A 1 227 ? 12.79781  7.74399  12.76161  1.000 44.04806  ? 227 LEU A HD11 1 
ATOM   3452 H HD12 . LEU A 1 227 ? 12.35678  6.22017  12.84511  1.000 44.04806  ? 227 LEU A HD12 1 
ATOM   3453 H HD13 . LEU A 1 227 ? 13.32553  6.82821  13.94752  1.000 44.04806  ? 227 LEU A HD13 1 
ATOM   3454 H HD21 . LEU A 1 227 ? 15.88284  7.40375  11.31478  1.000 42.71008  ? 227 LEU A HD21 1 
ATOM   3455 H HD22 . LEU A 1 227 ? 14.61115  8.34499  11.45755  1.000 42.71008  ? 227 LEU A HD22 1 
ATOM   3456 H HD23 . LEU A 1 227 ? 15.49420  8.00403  12.73328  1.000 42.71008  ? 227 LEU A HD23 1 
ATOM   3457 N N    . ASN A 1 228 ? 14.57901  2.55607  11.40409  1.000 33.55140  ? 228 ASN A N    1 
ATOM   3458 C CA   . ASN A 1 228 ? 14.07866  1.80470  10.26042  1.000 37.41046  ? 228 ASN A CA   1 
ATOM   3459 C C    . ASN A 1 228 ? 13.03687  0.78995  10.68702  1.000 31.23831  ? 228 ASN A C    1 
ATOM   3460 O O    . ASN A 1 228 ? 11.98521  0.66035  10.05233  1.000 36.24755  ? 228 ASN A O    1 
ATOM   3461 C CB   . ASN A 1 228 ? 15.23452  1.10401  9.53607   1.000 49.63210  ? 228 ASN A CB   1 
ATOM   3462 C CG   . ASN A 1 228 ? 16.11615  2.07407  8.77283   1.000 62.76784  ? 228 ASN A CG   1 
ATOM   3463 O OD1  . ASN A 1 228 ? 15.75730  3.24131  8.57879   1.000 58.91979  ? 228 ASN A OD1  1 
ATOM   3464 N ND2  . ASN A 1 228 ? 17.27400  1.59566  8.32580   1.000 63.99092  ? 228 ASN A ND2  1 
ATOM   3465 H H    . ASN A 1 228 ? 15.41423  2.44253  11.57475  1.000 40.26168  ? 228 ASN A H    1 
ATOM   3466 H HA   . ASN A 1 228 ? 13.66627  2.42773  9.64182   1.000 44.89255  ? 228 ASN A HA   1 
ATOM   3467 H HB2  . ASN A 1 228 ? 15.78642  0.64586  10.18907  1.000 59.55852  ? 228 ASN A HB2  1 
ATOM   3468 H HB3  . ASN A 1 228 ? 14.87100  0.46565  8.90262   1.000 59.55852  ? 228 ASN A HB3  1 
ATOM   3469 H HD21 . ASN A 1 228 ? 17.80951  2.10600  7.88719   1.000 76.78911  ? 228 ASN A HD21 1 
ATOM   3470 H HD22 . ASN A 1 228 ? 17.48707  0.77601  8.47538   1.000 76.78911  ? 228 ASN A HD22 1 
ATOM   3471 N N    . ASP A 1 229 ? 13.31146  0.04246  11.76782  1.000 29.53419  ? 229 ASP A N    1 
ATOM   3472 C CA   . ASP A 1 229 ? 12.35294  -0.96482 12.21169  1.000 35.52618  ? 229 ASP A CA   1 
ATOM   3473 C C    . ASP A 1 229 ? 11.05143  -0.31163 12.67599  1.000 35.47862  ? 229 ASP A C    1 
ATOM   3474 O O    . ASP A 1 229 ? 9.95576   -0.84984 12.45769  1.000 33.81615  ? 229 ASP A O    1 
ATOM   3475 C CB   . ASP A 1 229 ? 12.95793  -1.83178 13.31780  1.000 39.61236  ? 229 ASP A CB   1 
ATOM   3476 C CG   . ASP A 1 229 ? 14.07344  -2.74528 12.79870  1.000 73.24843  ? 229 ASP A CG   1 
ATOM   3477 O OD1  . ASP A 1 229 ? 14.14044  -2.97437 11.56424  1.000 63.10817  ? 229 ASP A OD1  1 
ATOM   3478 O OD2  . ASP A 1 229 ? 14.87556  -3.23556 13.62430  1.000 69.52195  ? 229 ASP A OD2  1 
ATOM   3479 H H    . ASP A 1 229 ? 14.02544  0.10109  12.24363  1.000 35.44103  ? 229 ASP A H    1 
ATOM   3480 H HA   . ASP A 1 229 ? 12.14703  -1.55142 11.46712  1.000 42.63142  ? 229 ASP A HA   1 
ATOM   3481 H HB2  . ASP A 1 229 ? 13.33346  -1.25649 14.00258  1.000 47.53483  ? 229 ASP A HB2  1 
ATOM   3482 H HB3  . ASP A 1 229 ? 12.26299  -2.39105 13.69881  1.000 47.53483  ? 229 ASP A HB3  1 
ATOM   3483 N N    . PHE A 1 230 ? 11.14764  0.85792  13.31363  1.000 32.69906  ? 230 PHE A N    1 
ATOM   3484 C CA   . PHE A 1 230 ? 9.92257   1.54291  13.71013  1.000 29.35543  ? 230 PHE A CA   1 
ATOM   3485 C C    . PHE A 1 230 ? 9.11316   1.96481  12.48625  1.000 27.67499  ? 230 PHE A C    1 
ATOM   3486 O O    . PHE A 1 230 ? 7.89813   1.78157  12.45237  1.000 28.19671  ? 230 PHE A O    1 
ATOM   3487 C CB   . PHE A 1 230 ? 10.22082  2.78110  14.54137  1.000 24.27653  ? 230 PHE A CB   1 
ATOM   3488 C CG   . PHE A 1 230 ? 8.98471   3.57642  14.84088  1.000 26.19412  ? 230 PHE A CG   1 
ATOM   3489 C CD1  . PHE A 1 230 ? 8.11213   3.17923  15.83757  1.000 26.32111  ? 230 PHE A CD1  1 
ATOM   3490 C CD2  . PHE A 1 230 ? 8.66148   4.69125  14.06519  1.000 27.95550  ? 230 PHE A CD2  1 
ATOM   3491 C CE1  . PHE A 1 230 ? 6.95347   3.89984  16.08014  1.000 31.67284  ? 230 PHE A CE1  1 
ATOM   3492 C CE2  . PHE A 1 230 ? 7.50122   5.40617  14.31330  1.000 31.69006  ? 230 PHE A CE2  1 
ATOM   3493 C CZ   . PHE A 1 230 ? 6.65841   5.01178  15.32492  1.000 25.77023  ? 230 PHE A CZ   1 
ATOM   3494 H H    . PHE A 1 230 ? 11.88082  1.25775  13.51902  1.000 39.23887  ? 230 PHE A H    1 
ATOM   3495 H HA   . PHE A 1 230 ? 9.40916   0.92514  14.25389  1.000 35.22651  ? 230 PHE A HA   1 
ATOM   3496 H HB2  . PHE A 1 230 ? 10.61739  2.50993  15.38404  1.000 29.13183  ? 230 PHE A HB2  1 
ATOM   3497 H HB3  . PHE A 1 230 ? 10.83588  3.35067  14.05331  1.000 29.13183  ? 230 PHE A HB3  1 
ATOM   3498 H HD1  . PHE A 1 230 ? 8.30370   2.42530  16.34726  1.000 31.58533  ? 230 PHE A HD1  1 
ATOM   3499 H HD2  . PHE A 1 230 ? 9.22884   4.95565  13.37737  1.000 33.54660  ? 230 PHE A HD2  1 
ATOM   3500 H HE1  . PHE A 1 230 ? 6.37339   3.63107  16.75555  1.000 38.00741  ? 230 PHE A HE1  1 
ATOM   3501 H HE2  . PHE A 1 230 ? 7.29308   6.15100  13.79677  1.000 38.02808  ? 230 PHE A HE2  1 
ATOM   3502 H HZ   . PHE A 1 230 ? 5.88545   5.49846  15.49977  1.000 30.92427  ? 230 PHE A HZ   1 
ATOM   3503 N N    . ASN A 1 231 ? 9.78046   2.50458  11.47501  1.000 27.16623  ? 231 ASN A N    1 
ATOM   3504 C CA   . ASN A 1 231 ? 9.07100   2.98835  10.28779  1.000 31.16055  ? 231 ASN A CA   1 
ATOM   3505 C C    . ASN A 1 231 ? 8.41960   1.85674  9.50448   1.000 32.03706  ? 231 ASN A C    1 
ATOM   3506 O O    . ASN A 1 231 ? 7.40886   2.08658  8.82768   1.000 30.89058  ? 231 ASN A O    1 
ATOM   3507 C CB   . ASN A 1 231 ? 9.98806   3.84806  9.43642   1.000 27.56776  ? 231 ASN A CB   1 
ATOM   3508 C CG   . ASN A 1 231 ? 10.11589  5.26183  9.96484   1.000 35.32546  ? 231 ASN A CG   1 
ATOM   3509 O OD1  . ASN A 1 231 ? 9.15017   5.82386  10.47189  1.000 39.36183  ? 231 ASN A OD1  1 
ATOM   3510 N ND2  . ASN A 1 231 ? 11.30747  5.83898  9.88107   1.000 31.50993  ? 231 ASN A ND2  1 
ATOM   3511 H H    . ASN A 1 231 ? 10.63428  2.60357  11.44667  1.000 32.59948  ? 231 ASN A H    1 
ATOM   3512 H HA   . ASN A 1 231 ? 8.34637   3.57433  10.55692  1.000 37.39266  ? 231 ASN A HA   1 
ATOM   3513 H HB2  . ASN A 1 231 ? 10.87286  3.45076  9.42337   1.000 33.08131  ? 231 ASN A HB2  1 
ATOM   3514 H HB3  . ASN A 1 231 ? 9.63208   3.89487  8.53532   1.000 33.08131  ? 231 ASN A HB3  1 
ATOM   3515 H HD21 . ASN A 1 231 ? 11.41807  6.64110  10.17086  1.000 37.81191  ? 231 ASN A HD21 1 
ATOM   3516 H HD22 . ASN A 1 231 ? 11.96931  5.41101  9.53697   1.000 37.81191  ? 231 ASN A HD22 1 
ATOM   3517 N N    . LEU A 1 232 ? 8.94127   0.63287  9.61291   1.000 29.27318  ? 232 LEU A N    1 
ATOM   3518 C CA   . LEU A 1 232 ? 8.23131   -0.51428 9.05814   1.000 29.02592  ? 232 LEU A CA   1 
ATOM   3519 C C    . LEU A 1 232 ? 6.90452   -0.72957 9.75772   1.000 32.15188  ? 232 LEU A C    1 
ATOM   3520 O O    . LEU A 1 232 ? 5.90142   -1.06713 9.11627   1.000 34.96568  ? 232 LEU A O    1 
ATOM   3521 C CB   . LEU A 1 232 ? 9.10156   -1.76943 9.19577   1.000 35.02091  ? 232 LEU A CB   1 
ATOM   3522 C CG   . LEU A 1 232 ? 10.29224  -1.88442 8.24067   1.000 52.78594  ? 232 LEU A CG   1 
ATOM   3523 C CD1  . LEU A 1 232 ? 11.13874  -3.09599 8.60369   1.000 55.85363  ? 232 LEU A CD1  1 
ATOM   3524 C CD2  . LEU A 1 232 ? 9.81619   -1.97861 6.80205   1.000 43.37129  ? 232 LEU A CD2  1 
ATOM   3525 H H    . LEU A 1 232 ? 9.68864   0.44565  9.99498   1.000 35.12782  ? 232 LEU A H    1 
ATOM   3526 H HA   . LEU A 1 232 ? 8.05771   -0.35219 8.11766   1.000 34.83111  ? 232 LEU A HA   1 
ATOM   3527 H HB2  . LEU A 1 232 ? 9.45704   -1.79085 10.09803  1.000 42.02509  ? 232 LEU A HB2  1 
ATOM   3528 H HB3  . LEU A 1 232 ? 8.53787   -2.54387 9.04280   1.000 42.02509  ? 232 LEU A HB3  1 
ATOM   3529 H HG   . LEU A 1 232 ? 10.84358  -1.09035 8.32057   1.000 63.34312  ? 232 LEU A HG   1 
ATOM   3530 H HD11 . LEU A 1 232 ? 11.83791  -3.20309 7.93992   1.000 67.02435  ? 232 LEU A HD11 1 
ATOM   3531 H HD12 . LEU A 1 232 ? 11.53238  -2.95539 9.47901   1.000 67.02435  ? 232 LEU A HD12 1 
ATOM   3532 H HD13 . LEU A 1 232 ? 10.57289  -3.88371 8.61814   1.000 67.02435  ? 232 LEU A HD13 1 
ATOM   3533 H HD21 . LEU A 1 232 ? 10.53731  -2.32378 6.25274   1.000 52.04555  ? 232 LEU A HD21 1 
ATOM   3534 H HD22 . LEU A 1 232 ? 9.05336   -2.57632 6.76033   1.000 52.04555  ? 232 LEU A HD22 1 
ATOM   3535 H HD23 . LEU A 1 232 ? 9.56083   -1.09450 6.49538   1.000 52.04555  ? 232 LEU A HD23 1 
ATOM   3536 N N    . VAL A 1 233 ? 6.87872   -0.55531 11.08812  1.000 29.58410  ? 233 VAL A N    1 
ATOM   3537 C CA   . VAL A 1 233 ? 5.62285   -0.69170 11.81974  1.000 28.61545  ? 233 VAL A CA   1 
ATOM   3538 C C    . VAL A 1 233 ? 4.68731   0.47113  11.50026  1.000 28.26614  ? 233 VAL A C    1 
ATOM   3539 O O    . VAL A 1 233 ? 3.47462   0.28239  11.31705  1.000 31.45981  ? 233 VAL A O    1 
ATOM   3540 C CB   . VAL A 1 233 ? 5.91046   -0.80277 13.32160  1.000 35.39869  ? 233 VAL A CB   1 
ATOM   3541 C CG1  . VAL A 1 233 ? 4.60936   -0.97947 14.11896  1.000 40.10543  ? 233 VAL A CG1  1 
ATOM   3542 C CG2  . VAL A 1 233 ? 6.88232   -1.95701 13.57869  1.000 32.45623  ? 233 VAL A CG2  1 
ATOM   3543 H H    . VAL A 1 233 ? 7.56114   -0.36220 11.57456  1.000 35.50092  ? 233 VAL A H    1 
ATOM   3544 H HA   . VAL A 1 233 ? 5.17877   -1.50615 11.53625  1.000 34.33853  ? 233 VAL A HA   1 
ATOM   3545 H HB   . VAL A 1 233 ? 6.32402   0.01855  13.63031  1.000 42.47843  ? 233 VAL A HB   1 
ATOM   3546 H HG11 . VAL A 1 233 ? 4.82672   -1.08770 15.05808  1.000 48.12652  ? 233 VAL A HG11 1 
ATOM   3547 H HG12 . VAL A 1 233 ? 4.05457   -0.19330 13.99632  1.000 48.12652  ? 233 VAL A HG12 1 
ATOM   3548 H HG13 . VAL A 1 233 ? 4.14436   -1.76639 13.79424  1.000 48.12652  ? 233 VAL A HG13 1 
ATOM   3549 H HG21 . VAL A 1 233 ? 6.87772   -2.16884 14.52526  1.000 38.94748  ? 233 VAL A HG21 1 
ATOM   3550 H HG22 . VAL A 1 233 ? 6.59804   -2.72947 13.06548  1.000 38.94748  ? 233 VAL A HG22 1 
ATOM   3551 H HG23 . VAL A 1 233 ? 7.77275   -1.68714 13.30445  1.000 38.94748  ? 233 VAL A HG23 1 
ATOM   3552 N N    . ALA A 1 234 ? 5.22971   1.68648  11.41997  1.000 31.16918  ? 234 ALA A N    1 
ATOM   3553 C CA   . ALA A 1 234 ? 4.40463   2.85320  11.11112  1.000 31.69124  ? 234 ALA A CA   1 
ATOM   3554 C C    . ALA A 1 234 ? 3.66253   2.66445  9.79672   1.000 31.50691  ? 234 ALA A C    1 
ATOM   3555 O O    . ALA A 1 234 ? 2.45480   2.89722  9.70870   1.000 29.94560  ? 234 ALA A O    1 
ATOM   3556 C CB   . ALA A 1 234 ? 5.27986   4.10852  11.05686  1.000 32.27263  ? 234 ALA A CB   1 
ATOM   3557 H H    . ALA A 1 234 ? 6.06340   1.86106  11.53861  1.000 37.40301  ? 234 ALA A H    1 
ATOM   3558 H HA   . ALA A 1 234 ? 3.74798   2.96907  11.81560  1.000 38.02948  ? 234 ALA A HA   1 
ATOM   3559 H HB1  . ALA A 1 234 ? 5.93767   4.00463  10.35160  1.000 38.72715  ? 234 ALA A HB1  1 
ATOM   3560 H HB2  . ALA A 1 234 ? 4.71781   4.87772  10.87426  1.000 38.72715  ? 234 ALA A HB2  1 
ATOM   3561 H HB3  . ALA A 1 234 ? 5.72560   4.21989  11.91115  1.000 38.72715  ? 234 ALA A HB3  1 
ATOM   3562 N N    . MET A 1 235 ? 4.37218   2.22138  8.76125   1.000 29.17733  ? 235 MET A N    1 
ATOM   3563 C CA   . MET A 1 235 ? 3.72561   1.98618  7.47007   1.000 28.52175  ? 235 MET A CA   1 
ATOM   3564 C C    . MET A 1 235 ? 2.55037   1.02618  7.59983   1.000 31.60601  ? 235 MET A C    1 
ATOM   3565 O O    . MET A 1 235 ? 1.47693   1.26659  7.03305   1.000 35.36669  ? 235 MET A O    1 
ATOM   3566 C CB   . MET A 1 235 ? 4.75555   1.45496  6.47822   1.000 45.59068  ? 235 MET A CB   1 
ATOM   3567 C CG   . MET A 1 235 ? 4.23524   1.34737  5.04118   1.000 59.89144  ? 235 MET A CG   1 
ATOM   3568 S SD   . MET A 1 235 ? 5.50639   1.75741  3.82526   1.000 80.32416  ? 235 MET A SD   1 
ATOM   3569 C CE   . MET A 1 235 ? 6.79842   0.58463  4.26651   1.000 72.86042  ? 235 MET A CE   1 
ATOM   3570 H H    . MET A 1 235 ? 5.21506   2.05138  8.77739   1.000 35.01279  ? 235 MET A H    1 
ATOM   3571 H HA   . MET A 1 235 ? 3.38690   2.82935  7.13060   1.000 34.22610  ? 235 MET A HA   1 
ATOM   3572 H HB2  . MET A 1 235 ? 5.51914   2.05312  6.47208   1.000 54.70881  ? 235 MET A HB2  1 
ATOM   3573 H HB3  . MET A 1 235 ? 5.03076   0.56854  6.76006   1.000 54.70881  ? 235 MET A HB3  1 
ATOM   3574 H HG2  . MET A 1 235 ? 3.94075   0.43798  4.87628   1.000 71.86973  ? 235 MET A HG2  1 
ATOM   3575 H HG3  . MET A 1 235 ? 3.49442   1.96243  4.92376   1.000 71.86973  ? 235 MET A HG3  1 
ATOM   3576 H HE1  . MET A 1 235 ? 6.44896   -0.31639 4.18315   1.000 87.43251  ? 235 MET A HE1  1 
ATOM   3577 H HE2  . MET A 1 235 ? 7.55154   0.70409  3.66697   1.000 87.43251  ? 235 MET A HE2  1 
ATOM   3578 H HE3  . MET A 1 235 ? 7.07487   0.74884  5.18166   1.000 87.43251  ? 235 MET A HE3  1 
ATOM   3579 N N    . LYS A 1 236 ? 2.71955   -0.05819 8.37515   1.000 30.76619  ? 236 LYS A N    1 
ATOM   3580 C CA   . LYS A 1 236 ? 1.66242   -1.05032 8.49226   1.000 26.09642  ? 236 LYS A CA   1 
ATOM   3581 C C    . LYS A 1 236 ? 0.41426   -0.49628 9.14333   1.000 31.69018  ? 236 LYS A C    1 
ATOM   3582 O O    . LYS A 1 236 ? -0.70232  -0.94478 8.82987   1.000 31.82418  ? 236 LYS A O    1 
ATOM   3583 C CB   . LYS A 1 236 ? 2.17089   -2.27210 9.26118   1.000 33.63171  ? 236 LYS A CB   1 
ATOM   3584 C CG   . LYS A 1 236 ? 1.09409   -3.28293 9.62764   1.000 47.27042  ? 236 LYS A CG   1 
ATOM   3585 C CD   . LYS A 1 236 ? 1.71494   -4.55978 10.21343  1.000 63.42508  ? 236 LYS A CD   1 
ATOM   3586 C CE   . LYS A 1 236 ? 0.76202   -5.29361 11.15711  1.000 62.67579  ? 236 LYS A CE   1 
ATOM   3587 N NZ   . LYS A 1 236 ? -0.47113  -5.80021 10.48810  1.000 60.14406  ? 236 LYS A NZ   1 
ATOM   3588 H H    . LYS A 1 236 ? 3.42712   -0.23209 8.83199   1.000 36.91943  ? 236 LYS A H    1 
ATOM   3589 H HA   . LYS A 1 236 ? 1.41624   -1.33496 7.59824   1.000 31.31571  ? 236 LYS A HA   1 
ATOM   3590 H HB2  . LYS A 1 236 ? 2.82773   -2.72990 8.71356   1.000 40.35806  ? 236 LYS A HB2  1 
ATOM   3591 H HB3  . LYS A 1 236 ? 2.58046   -1.96876 10.08649  1.000 40.35806  ? 236 LYS A HB3  1 
ATOM   3592 H HG2  . LYS A 1 236 ? 0.50119   -2.89734 10.29149  1.000 56.72450  ? 236 LYS A HG2  1 
ATOM   3593 H HG3  . LYS A 1 236 ? 0.59165   -3.52238 8.83321   1.000 56.72450  ? 236 LYS A HG3  1 
ATOM   3594 H HD2  . LYS A 1 236 ? 1.94409   -5.16268 9.48893   1.000 76.11010  ? 236 LYS A HD2  1 
ATOM   3595 H HD3  . LYS A 1 236 ? 2.51186   -4.32461 10.71395  1.000 76.11010  ? 236 LYS A HD3  1 
ATOM   3596 H HE2  . LYS A 1 236 ? 1.22532   -6.05524 11.53942  1.000 75.21095  ? 236 LYS A HE2  1 
ATOM   3597 H HE3  . LYS A 1 236 ? 0.48797   -4.68464 11.86065  1.000 75.21095  ? 236 LYS A HE3  1 
ATOM   3598 H HZ1  . LYS A 1 236 ? -0.25495  -6.38976 9.85739   1.000 72.17288  ? 236 LYS A HZ1  1 
ATOM   3599 H HZ2  . LYS A 1 236 ? -1.00018  -6.19606 11.08435  1.000 72.17288  ? 236 LYS A HZ2  1 
ATOM   3600 H HZ3  . LYS A 1 236 ? -0.91322  -5.12498 10.11299  1.000 72.17288  ? 236 LYS A HZ3  1 
ATOM   3601 N N    . TYR A 1 237 ? 0.56990   0.46748  10.05877  1.000 26.78143  ? 237 TYR A N    1 
ATOM   3602 C CA   . TYR A 1 237 ? -0.55151  1.04910  10.78375  1.000 27.53016  ? 237 TYR A CA   1 
ATOM   3603 C C    . TYR A 1 237 ? -0.97697  2.41715  10.23542  1.000 26.26442  ? 237 TYR A C    1 
ATOM   3604 O O    . TYR A 1 237 ? -1.73042  3.14022  10.89649  1.000 28.07579  ? 237 TYR A O    1 
ATOM   3605 C CB   . TYR A 1 237 ? -0.21504  1.13598  12.26944  1.000 22.18226  ? 237 TYR A CB   1 
ATOM   3606 C CG   . TYR A 1 237 ? -0.20367  -0.24865 12.90539  1.000 24.45904  ? 237 TYR A CG   1 
ATOM   3607 C CD1  . TYR A 1 237 ? -1.35786  -0.79956 13.40633  1.000 26.71640  ? 237 TYR A CD1  1 
ATOM   3608 C CD2  . TYR A 1 237 ? 0.96724   -0.98599 12.94632  1.000 30.67123  ? 237 TYR A CD2  1 
ATOM   3609 C CE1  . TYR A 1 237 ? -1.35502  -2.07174 13.96256  1.000 38.36309  ? 237 TYR A CE1  1 
ATOM   3610 C CE2  . TYR A 1 237 ? 0.98497   -2.25803 13.50659  1.000 33.04204  ? 237 TYR A CE2  1 
ATOM   3611 C CZ   . TYR A 1 237 ? -0.18155  -2.79128 13.99372  1.000 34.54392  ? 237 TYR A CZ   1 
ATOM   3612 O OH   . TYR A 1 237 ? -0.18033  -4.05357 14.56093  1.000 42.88732  ? 237 TYR A OH   1 
ATOM   3613 H H    . TYR A 1 237 ? 1.33134   0.80262  10.27669  1.000 32.13772  ? 237 TYR A H    1 
ATOM   3614 H HA   . TYR A 1 237 ? -1.31801  0.46284  10.68541  1.000 33.03620  ? 237 TYR A HA   1 
ATOM   3615 H HB2  . TYR A 1 237 ? 0.66331   1.53272  12.37897  1.000 26.61871  ? 237 TYR A HB2  1 
ATOM   3616 H HB3  . TYR A 1 237 ? -0.88200  1.67690  12.72051  1.000 26.61871  ? 237 TYR A HB3  1 
ATOM   3617 H HD1  . TYR A 1 237 ? -2.15073  -0.31467 13.37255  1.000 32.05968  ? 237 TYR A HD1  1 
ATOM   3618 H HD2  . TYR A 1 237 ? 1.74996   -0.62666 12.59542  1.000 36.80548  ? 237 TYR A HD2  1 
ATOM   3619 H HE1  . TYR A 1 237 ? -2.13766  -2.43410 14.31049  1.000 46.03570  ? 237 TYR A HE1  1 
ATOM   3620 H HE2  . TYR A 1 237 ? 1.77802   -2.74180 13.55070  1.000 39.65044  ? 237 TYR A HE2  1 
ATOM   3621 H HH   . TYR A 1 237 ? 0.55975   -4.42781 14.42742  1.000 51.46478  ? 237 TYR A HH   1 
ATOM   3622 N N    . ASN A 1 238 ? -0.54952  2.76095  9.02437   1.000 25.73326  ? 238 ASN A N    1 
ATOM   3623 C CA   . ASN A 1 238 ? -0.95616  4.01858  8.37889   1.000 23.51834  ? 238 ASN A CA   1 
ATOM   3624 C C    . ASN A 1 238 ? -0.52571  5.24236  9.20580   1.000 25.06854  ? 238 ASN A C    1 
ATOM   3625 O O    . ASN A 1 238 ? -1.25082  6.23970  9.30193   1.000 25.57597  ? 238 ASN A O    1 
ATOM   3626 C CB   . ASN A 1 238 ? -2.45152  4.04646  8.12323   1.000 23.69225  ? 238 ASN A CB   1 
ATOM   3627 C CG   . ASN A 1 238 ? -2.84051  5.16151  7.18185   1.000 32.14477  ? 238 ASN A CG   1 
ATOM   3628 O OD1  . ASN A 1 238 ? -2.00885  5.62672  6.40765   1.000 35.28430  ? 238 ASN A OD1  1 
ATOM   3629 N ND2  . ASN A 1 238 ? -4.08149  5.62140  7.27351   1.000 36.39464  ? 238 ASN A ND2  1 
ATOM   3630 H H    . ASN A 1 238 ? -0.01816  2.28204  8.54698   1.000 30.87992  ? 238 ASN A H    1 
ATOM   3631 H HA   . ASN A 1 238 ? -0.50350  4.07445  7.52281   1.000 28.22201  ? 238 ASN A HA   1 
ATOM   3632 H HB2  . ASN A 1 238 ? -2.72344  3.20454  7.72558   1.000 28.43070  ? 238 ASN A HB2  1 
ATOM   3633 H HB3  . ASN A 1 238 ? -2.91685  4.18213  8.96345   1.000 28.43070  ? 238 ASN A HB3  1 
ATOM   3634 H HD21 . ASN A 1 238 ? -4.34419  6.25607  6.75603   1.000 43.67357  ? 238 ASN A HD21 1 
ATOM   3635 H HD22 . ASN A 1 238 ? -4.62328  5.28485  7.85040   1.000 43.67357  ? 238 ASN A HD22 1 
ATOM   3636 N N    . TYR A 1 239 ? 0.67144   5.17856  9.76133   1.000 22.66818  ? 239 TYR A N    1 
ATOM   3637 C CA   . TYR A 1 239 ? 1.32500   6.29269  10.41981  1.000 22.29609  ? 239 TYR A CA   1 
ATOM   3638 C C    . TYR A 1 239 ? 2.37406   6.87113  9.47952   1.000 27.06196  ? 239 TYR A C    1 
ATOM   3639 O O    . TYR A 1 239 ? 3.01963   6.14393  8.73448   1.000 27.83988  ? 239 TYR A O    1 
ATOM   3640 C CB   . TYR A 1 239 ? 2.04397   5.80639  11.69532  1.000 21.45716  ? 239 TYR A CB   1 
ATOM   3641 C CG   . TYR A 1 239 ? 1.20620   5.82413  12.94548  1.000 21.03001  ? 239 TYR A CG   1 
ATOM   3642 C CD1  . TYR A 1 239 ? -0.04326  5.21320  13.01593  1.000 20.41940  ? 239 TYR A CD1  1 
ATOM   3643 C CD2  . TYR A 1 239 ? 1.69010   6.44486  14.08335  1.000 20.29686  ? 239 TYR A CD2  1 
ATOM   3644 C CE1  . TYR A 1 239 ? -0.79220  5.24153  14.17543  1.000 23.63763  ? 239 TYR A CE1  1 
ATOM   3645 C CE2  . TYR A 1 239 ? 0.94730   6.47475  15.27089  1.000 20.36509  ? 239 TYR A CE2  1 
ATOM   3646 C CZ   . TYR A 1 239 ? -0.26667  5.88366  15.31577  1.000 20.49259  ? 239 TYR A CZ   1 
ATOM   3647 O OH   . TYR A 1 239 ? -0.98160  5.94337  16.48209  1.000 23.50681  ? 239 TYR A OH   1 
ATOM   3648 H H    . TYR A 1 239 ? 1.14929   4.46359  9.76992   1.000 27.20181  ? 239 TYR A H    1 
ATOM   3649 H HA   . TYR A 1 239 ? 0.67386   6.97193  10.65551  1.000 26.75531  ? 239 TYR A HA   1 
ATOM   3650 H HB2  . TYR A 1 239 ? 2.33510   4.89201  11.55368  1.000 25.74860  ? 239 TYR A HB2  1 
ATOM   3651 H HB3  . TYR A 1 239 ? 2.81152   6.37846  11.85186  1.000 25.74860  ? 239 TYR A HB3  1 
ATOM   3652 H HD1  . TYR A 1 239 ? -0.38005  4.77724  12.26666  1.000 24.50328  ? 239 TYR A HD1  1 
ATOM   3653 H HD2  . TYR A 1 239 ? 2.52639   6.85099  14.05940  1.000 24.35623  ? 239 TYR A HD2  1 
ATOM   3654 H HE1  . TYR A 1 239 ? -1.63181  4.84261  14.20409  1.000 28.36516  ? 239 TYR A HE1  1 
ATOM   3655 H HE2  . TYR A 1 239 ? 1.28831   6.89947  16.02470  1.000 24.43811  ? 239 TYR A HE2  1 
ATOM   3656 H HH   . TYR A 1 239 ? -1.75954  5.65206  16.35743  1.000 28.20818  ? 239 TYR A HH   1 
ATOM   3657 N N    . GLU A 1 240 ? 2.57721   8.18379  9.55601   1.000 19.73661  ? 240 GLU A N    1 
ATOM   3658 C CA   . GLU A 1 240 ? 3.56556   8.82048  8.71668   1.000 22.20305  ? 240 GLU A CA   1 
ATOM   3659 C C    . GLU A 1 240 ? 4.94379   8.35823  9.14102   1.000 25.20964  ? 240 GLU A C    1 
ATOM   3660 O O    . GLU A 1 240 ? 5.17407   8.05930  10.30804  1.000 24.77540  ? 240 GLU A O    1 
ATOM   3661 C CB   . GLU A 1 240 ? 3.45735   10.33890 8.81691   1.000 25.22959  ? 240 GLU A CB   1 
ATOM   3662 C CG   . GLU A 1 240 ? 2.13463   10.86507 8.32030   1.000 40.94917  ? 240 GLU A CG   1 
ATOM   3663 C CD   . GLU A 1 240 ? 2.20250   12.33270 7.94493   1.000 57.02212  ? 240 GLU A CD   1 
ATOM   3664 O OE1  . GLU A 1 240 ? 2.53597   13.14952 8.83198   1.000 50.69653  ? 240 GLU A OE1  1 
ATOM   3665 O OE2  . GLU A 1 240 ? 1.93808   12.65050 6.76081   1.000 53.13399  ? 240 GLU A OE2  1 
ATOM   3666 H H    . GLU A 1 240 ? 2.15624   8.71725  10.08307  1.000 23.68394  ? 240 GLU A H    1 
ATOM   3667 H HA   . GLU A 1 240 ? 3.42728   8.58308  7.78640   1.000 26.64366  ? 240 GLU A HA   1 
ATOM   3668 H HB2  . GLU A 1 240 ? 3.55518   10.60144 9.74557   1.000 30.27551  ? 240 GLU A HB2  1 
ATOM   3669 H HB3  . GLU A 1 240 ? 4.15999   10.74111 8.28266   1.000 30.27551  ? 240 GLU A HB3  1 
ATOM   3670 H HG2  . GLU A 1 240 ? 1.86879   10.36432 7.53323   1.000 49.13900  ? 240 GLU A HG2  1 
ATOM   3671 H HG3  . GLU A 1 240 ? 1.46950   10.76277 9.01890   1.000 49.13900  ? 240 GLU A HG3  1 
ATOM   3672 N N    . PRO A 1 241 ? 5.88201   8.23826  8.20917   1.000 24.00573  ? 241 PRO A N    1 
ATOM   3673 C CA   . PRO A 1 241 ? 7.24483   7.86787  8.61302   1.000 25.71944  ? 241 PRO A CA   1 
ATOM   3674 C C    . PRO A 1 241 ? 7.86355   8.91900  9.51479   1.000 24.16158  ? 241 PRO A C    1 
ATOM   3675 O O    . PRO A 1 241 ? 7.55806   10.11438 9.44330   1.000 30.16682  ? 241 PRO A O    1 
ATOM   3676 C CB   . PRO A 1 241 ? 8.00466   7.74472  7.27063   1.000 35.44453  ? 241 PRO A CB   1 
ATOM   3677 C CG   . PRO A 1 241 ? 7.10830   8.30945  6.23919   1.000 32.69858  ? 241 PRO A CG   1 
ATOM   3678 C CD   . PRO A 1 241 ? 5.70727   8.24817  6.73512   1.000 33.80735  ? 241 PRO A CD   1 
ATOM   3679 H HA   . PRO A 1 241 ? 7.24745   7.00987  9.06548   1.000 30.86333  ? 241 PRO A HA   1 
ATOM   3680 H HB2  . PRO A 1 241 ? 8.83296   8.24730  7.31791   1.000 42.53343  ? 241 PRO A HB2  1 
ATOM   3681 H HB3  . PRO A 1 241 ? 8.19314   6.81099  7.08752   1.000 42.53343  ? 241 PRO A HB3  1 
ATOM   3682 H HG2  . PRO A 1 241 ? 7.36182   9.23066  6.07184   1.000 39.23830  ? 241 PRO A HG2  1 
ATOM   3683 H HG3  . PRO A 1 241 ? 7.19627   7.78816  5.42591   1.000 39.23830  ? 241 PRO A HG3  1 
ATOM   3684 H HD2  . PRO A 1 241 ? 5.20361   9.02668  6.45027   1.000 40.56882  ? 241 PRO A HD2  1 
ATOM   3685 H HD3  . PRO A 1 241 ? 5.26664   7.43888  6.43212   1.000 40.56882  ? 241 PRO A HD3  1 
ATOM   3686 N N    . LEU A 1 242 ? 8.71323   8.45749  10.42144  1.000 29.86678  ? 242 LEU A N    1 
ATOM   3687 C CA   . LEU A 1 242 ? 9.41454   9.33445  11.33976  1.000 23.67764  ? 242 LEU A CA   1 
ATOM   3688 C C    . LEU A 1 242 ? 10.78071  9.64670  10.75274  1.000 28.43809  ? 242 LEU A C    1 
ATOM   3689 O O    . LEU A 1 242 ? 11.51216  8.73345  10.38195  1.000 30.22432  ? 242 LEU A O    1 
ATOM   3690 C CB   . LEU A 1 242 ? 9.58626   8.63611  12.69543  1.000 26.79058  ? 242 LEU A CB   1 
ATOM   3691 C CG   . LEU A 1 242 ? 9.98218   9.51117  13.88363  1.000 25.61018  ? 242 LEU A CG   1 
ATOM   3692 C CD1  . LEU A 1 242 ? 8.87976   10.51563 14.17515  1.000 28.84939  ? 242 LEU A CD1  1 
ATOM   3693 C CD2  . LEU A 1 242 ? 10.27574  8.62302  15.09135  1.000 28.02973  ? 242 LEU A CD2  1 
ATOM   3694 H H    . LEU A 1 242 ? 8.90183   7.62472  10.52399  1.000 35.84014  ? 242 LEU A H    1 
ATOM   3695 H HA   . LEU A 1 242 ? 8.92323   10.16087 11.46841  1.000 28.41317  ? 242 LEU A HA   1 
ATOM   3696 H HB2  . LEU A 1 242 ? 8.74235   8.21555  12.92313  1.000 32.14870  ? 242 LEU A HB2  1 
ATOM   3697 H HB3  . LEU A 1 242 ? 10.27718  7.96225  12.59824  1.000 32.14870  ? 242 LEU A HB3  1 
ATOM   3698 H HG   . LEU A 1 242 ? 10.78629  10.01583 13.68457  1.000 30.73221  ? 242 LEU A HG   1 
ATOM   3699 H HD11 . LEU A 1 242 ? 8.02389   10.05951 14.15634  1.000 34.61927  ? 242 LEU A HD11 1 
ATOM   3700 H HD12 . LEU A 1 242 ? 9.02905   10.90278 15.05192  1.000 34.61927  ? 242 LEU A HD12 1 
ATOM   3701 H HD13 . LEU A 1 242 ? 8.89903   11.21081 13.49895  1.000 34.61927  ? 242 LEU A HD13 1 
ATOM   3702 H HD21 . LEU A 1 242 ? 9.44040   8.26564  15.43103  1.000 33.63568  ? 242 LEU A HD21 1 
ATOM   3703 H HD22 . LEU A 1 242 ? 10.85811  7.89783  14.81595  1.000 33.63568  ? 242 LEU A HD22 1 
ATOM   3704 H HD23 . LEU A 1 242 ? 10.71078  9.15477  15.77610  1.000 33.63568  ? 242 LEU A HD23 1 
ATOM   3705 N N    . THR A 1 243 ? 11.10362  10.93429 10.67344  1.000 28.34623  ? 243 THR A N    1 
ATOM   3706 C CA   . THR A 1 243 ? 12.37766  11.37661 10.12816  1.000 31.89430  ? 243 THR A CA   1 
ATOM   3707 C C    . THR A 1 243 ? 13.33776  11.71864 11.25558  1.000 30.08177  ? 243 THR A C    1 
ATOM   3708 O O    . THR A 1 243 ? 12.94240  12.01655 12.40338  1.000 24.45273  ? 243 THR A O    1 
ATOM   3709 C CB   . THR A 1 243 ? 12.20795  12.62025 9.25834   1.000 28.44289  ? 243 THR A CB   1 
ATOM   3710 O OG1  . THR A 1 243 ? 11.83187  13.71633 10.09023  1.000 28.40712  ? 243 THR A OG1  1 
ATOM   3711 C CG2  . THR A 1 243 ? 11.17668  12.40516 8.17434   1.000 27.35803  ? 243 THR A CG2  1 
ATOM   3712 H H    . THR A 1 243 ? 10.59328  11.57603 10.93290  1.000 34.01547  ? 243 THR A H    1 
ATOM   3713 H HA   . THR A 1 243 ? 12.74367  10.66078 9.58546   1.000 38.27316  ? 243 THR A HA   1 
ATOM   3714 H HB   . THR A 1 243 ? 13.04474  12.82146 8.81092   1.000 34.13146  ? 243 THR A HB   1 
ATOM   3715 H HG1  . THR A 1 243 ? 11.76103  14.41534 9.62984   1.000 34.08854  ? 243 THR A HG1  1 
ATOM   3716 H HG21 . THR A 1 243 ? 11.11711  13.19328 7.61201   1.000 32.82964  ? 243 THR A HG21 1 
ATOM   3717 H HG22 . THR A 1 243 ? 11.42572  11.64503 7.62563   1.000 32.82964  ? 243 THR A HG22 1 
ATOM   3718 H HG23 . THR A 1 243 ? 10.30818  12.23554 8.57163   1.000 32.82964  ? 243 THR A HG23 1 
ATOM   3719 N N    . GLN A 1 244 ? 14.62252  11.76505 10.90109  1.000 30.80416  ? 244 GLN A N    1 
ATOM   3720 C CA   . GLN A 1 244 ? 15.59865  12.25019 11.86651  1.000 26.41219  ? 244 GLN A CA   1 
ATOM   3721 C C    . GLN A 1 244 ? 15.28809  13.66171 12.33808  1.000 26.45939  ? 244 GLN A C    1 
ATOM   3722 O O    . GLN A 1 244 ? 15.56939  14.00549 13.49091  1.000 22.84687  ? 244 GLN A O    1 
ATOM   3723 C CB   . GLN A 1 244 ? 17.00982  12.18947 11.25437  1.000 27.17161  ? 244 GLN A CB   1 
ATOM   3724 C CG   . GLN A 1 244 ? 18.10167  12.55003 12.23861  1.000 28.52304  ? 244 GLN A CG   1 
ATOM   3725 C CD   . GLN A 1 244 ? 18.10595  11.63458 13.45387  1.000 28.77396  ? 244 GLN A CD   1 
ATOM   3726 O OE1  . GLN A 1 244 ? 17.92182  10.41862 13.32863  1.000 34.40401  ? 244 GLN A OE1  1 
ATOM   3727 N NE2  . GLN A 1 244 ? 18.29493  12.21604 14.62424  1.000 33.66129  ? 244 GLN A NE2  1 
ATOM   3728 H H    . GLN A 1 244 ? 14.94007  11.53012 10.13717  1.000 36.96499  ? 244 GLN A H    1 
ATOM   3729 H HA   . GLN A 1 244 ? 15.57600  11.67205 12.64507  1.000 31.69463  ? 244 GLN A HA   1 
ATOM   3730 H HB2  . GLN A 1 244 ? 17.17722  11.28728 10.93987  1.000 32.60593  ? 244 GLN A HB2  1 
ATOM   3731 H HB3  . GLN A 1 244 ? 17.05782  12.81343 10.51324  1.000 32.60593  ? 244 GLN A HB3  1 
ATOM   3732 H HG2  . GLN A 1 244 ? 18.96340  12.47389 11.79983  1.000 34.22765  ? 244 GLN A HG2  1 
ATOM   3733 H HG3  . GLN A 1 244 ? 17.96515  13.45983 12.54605  1.000 34.22765  ? 244 GLN A HG3  1 
ATOM   3734 H HE21 . GLN A 1 244 ? 18.40687  13.06759 14.66824  1.000 40.39355  ? 244 GLN A HE21 1 
ATOM   3735 H HE22 . GLN A 1 244 ? 18.30608  11.74320 15.34250  1.000 40.39355  ? 244 GLN A HE22 1 
ATOM   3736 N N    . ASP A 1 245 ? 14.70287  14.50157 11.48109  1.000 25.33162  ? 245 ASP A N    1 
ATOM   3737 C CA   . ASP A 1 245 ? 14.32858  15.83483 11.94700  1.000 25.39983  ? 245 ASP A CA   1 
ATOM   3738 C C    . ASP A 1 245 ? 13.26890  15.75971 13.04625  1.000 22.83305  ? 245 ASP A C    1 
ATOM   3739 O O    . ASP A 1 245 ? 13.31664  16.53065 14.00086  1.000 23.60918  ? 245 ASP A O    1 
ATOM   3740 C CB   . ASP A 1 245 ? 13.85756  16.70910 10.78717  1.000 28.47584  ? 245 ASP A CB   1 
ATOM   3741 C CG   . ASP A 1 245 ? 13.67698  18.16440 11.19623  1.000 41.01571  ? 245 ASP A CG   1 
ATOM   3742 O OD1  . ASP A 1 245 ? 14.58316  18.72017 11.85929  1.000 33.93829  ? 245 ASP A OD1  1 
ATOM   3743 O OD2  . ASP A 1 245 ? 12.64321  18.77203 10.84157  1.000 54.25342  ? 245 ASP A OD2  1 
ATOM   3744 H H    . ASP A 1 245 ? 14.51934  14.33022 10.65856  1.000 30.39794  ? 245 ASP A H    1 
ATOM   3745 H HA   . ASP A 1 245 ? 15.11689  16.26019 12.31920  1.000 30.47979  ? 245 ASP A HA   1 
ATOM   3746 H HB2  . ASP A 1 245 ? 14.51607  16.67507 10.07576  1.000 34.17101  ? 245 ASP A HB2  1 
ATOM   3747 H HB3  . ASP A 1 245 ? 13.00442  16.37791 10.46566  1.000 34.17101  ? 245 ASP A HB3  1 
ATOM   3748 N N    . HIS A 1 246 ? 12.31706  14.83421 12.91592  1.000 24.63779  ? 246 HIS A N    1 
ATOM   3749 C CA   . HIS A 1 246 ? 11.32600  14.63143 13.98258  1.000 23.42527  ? 246 HIS A CA   1 
ATOM   3750 C C    . HIS A 1 246 ? 12.00372  14.20570 15.27694  1.000 26.17237  ? 246 HIS A C    1 
ATOM   3751 O O    . HIS A 1 246 ? 11.64195  14.67912 16.36823  1.000 22.13232  ? 246 HIS A O    1 
ATOM   3752 C CB   . HIS A 1 246 ? 10.32750  13.56594 13.56416  1.000 22.91875  ? 246 HIS A CB   1 
ATOM   3753 C CG   . HIS A 1 246 ? 9.44496   13.96038 12.41971  1.000 24.01284  ? 246 HIS A CG   1 
ATOM   3754 N ND1  . HIS A 1 246 ? 9.01656   13.05723 11.46757  1.000 28.20449  ? 246 HIS A ND1  1 
ATOM   3755 C CD2  . HIS A 1 246 ? 8.91450   15.15806 12.07020  1.000 25.20949  ? 246 HIS A CD2  1 
ATOM   3756 C CE1  . HIS A 1 246 ? 8.25066   13.67667 10.58801  1.000 25.94564  ? 246 HIS A CE1  1 
ATOM   3757 N NE2  . HIS A 1 246 ? 8.16178   14.95400 10.93121  1.000 30.28329  ? 246 HIS A NE2  1 
ATOM   3758 H H    . HIS A 1 246 ? 12.22128  14.31825 12.23459  1.000 29.56535  ? 246 HIS A H    1 
ATOM   3759 H HA   . HIS A 1 246 ? 10.85259  15.46490 14.13125  1.000 28.11033  ? 246 HIS A HA   1 
ATOM   3760 H HB2  . HIS A 1 246 ? 10.81618  12.77159 13.29751  1.000 27.50250  ? 246 HIS A HB2  1 
ATOM   3761 H HB3  . HIS A 1 246 ? 9.75458   13.36469 14.32057  1.000 27.50250  ? 246 HIS A HB3  1 
ATOM   3762 H HD2  . HIS A 1 246 ? 9.03516   15.96601 12.51467  1.000 30.25138  ? 246 HIS A HD2  1 
ATOM   3763 H HE1  . HIS A 1 246 ? 7.84208   13.28277 9.85125   1.000 31.13477  ? 246 HIS A HE1  1 
ATOM   3764 H HE2  . HIS A 1 246 ? 7.71039   15.55536 10.51381  1.000 36.33995  ? 246 HIS A HE2  1 
ATOM   3765 N N    . VAL A 1 247 ? 12.98111  13.30636 15.17664  1.000 25.39995  ? 247 VAL A N    1 
ATOM   3766 C CA   . VAL A 1 247 ? 13.74166  12.88955 16.35565  1.000 22.04419  ? 247 VAL A CA   1 
ATOM   3767 C C    . VAL A 1 247 ? 14.41931  14.08798 16.98926  1.000 21.53826  ? 247 VAL A C    1 
ATOM   3768 O O    . VAL A 1 247 ? 14.39446  14.26209 18.20424  1.000 24.71773  ? 247 VAL A O    1 
ATOM   3769 C CB   . VAL A 1 247 ? 14.72065  11.76467 15.98660  1.000 27.36249  ? 247 VAL A CB   1 
ATOM   3770 C CG1  . VAL A 1 247 ? 15.59494  11.39327 17.15671  1.000 31.66731  ? 247 VAL A CG1  1 
ATOM   3771 C CG2  . VAL A 1 247 ? 13.95894  10.54812 15.50277  1.000 28.77347  ? 247 VAL A CG2  1 
ATOM   3772 H H    . VAL A 1 247 ? 13.22302  12.92463 14.44496  1.000 30.47994  ? 247 VAL A H    1 
ATOM   3773 H HA   . VAL A 1 247 ? 13.13414  12.52490 17.01810  1.000 26.45303  ? 247 VAL A HA   1 
ATOM   3774 H HB   . VAL A 1 247 ? 15.29630  12.08324 15.27384  1.000 32.83498  ? 247 VAL A HB   1 
ATOM   3775 H HG11 . VAL A 1 247 ? 16.06178  12.18528 17.46604  1.000 38.00077  ? 247 VAL A HG11 1 
ATOM   3776 H HG12 . VAL A 1 247 ? 15.03779  11.03903 17.86734  1.000 38.00077  ? 247 VAL A HG12 1 
ATOM   3777 H HG13 . VAL A 1 247 ? 16.23485  10.72206 16.87230  1.000 38.00077  ? 247 VAL A HG13 1 
ATOM   3778 H HG21 . VAL A 1 247 ? 14.58574  9.82440  15.34707  1.000 34.52817  ? 247 VAL A HG21 1 
ATOM   3779 H HG22 . VAL A 1 247 ? 13.31542  10.28832 16.18048  1.000 34.52817  ? 247 VAL A HG22 1 
ATOM   3780 H HG23 . VAL A 1 247 ? 13.49923  10.77072 14.67814  1.000 34.52817  ? 247 VAL A HG23 1 
ATOM   3781 N N    . ASP A 1 248 ? 15.03642  14.94382 16.17315  1.000 26.49976  ? 248 ASP A N    1 
ATOM   3782 C CA   . ASP A 1 248 ? 15.68572  16.12859 16.71280  1.000 29.21848  ? 248 ASP A CA   1 
ATOM   3783 C C    . ASP A 1 248 ? 14.69220  17.04612 17.39975  1.000 26.47408  ? 248 ASP A C    1 
ATOM   3784 O O    . ASP A 1 248 ? 14.97273  17.58987 18.47562  1.000 26.25587  ? 248 ASP A O    1 
ATOM   3785 C CB   . ASP A 1 248 ? 16.41723  16.88336 15.58113  1.000 31.04529  ? 248 ASP A CB   1 
ATOM   3786 C CG   . ASP A 1 248 ? 17.55111  16.07083 14.96806  1.000 36.94583  ? 248 ASP A CG   1 
ATOM   3787 O OD1  . ASP A 1 248 ? 18.03063  15.10519 15.60359  1.000 31.63972  ? 248 ASP A OD1  1 
ATOM   3788 O OD2  . ASP A 1 248 ? 17.96604  16.39881 13.82955  1.000 36.21047  ? 248 ASP A OD2  1 
ATOM   3789 H H    . ASP A 1 248 ? 15.09079  14.86019 15.31896  1.000 31.79971  ? 248 ASP A H    1 
ATOM   3790 H HA   . ASP A 1 248 ? 16.33974  15.85055 17.37299  1.000 35.06217  ? 248 ASP A HA   1 
ATOM   3791 H HB2  . ASP A 1 248 ? 15.78240  17.09079 14.87766  1.000 37.25434  ? 248 ASP A HB2  1 
ATOM   3792 H HB3  . ASP A 1 248 ? 16.79449  17.70198 15.93951  1.000 37.25434  ? 248 ASP A HB3  1 
ATOM   3793 N N    . ILE A 1 249 ? 13.51999  17.26172 16.78500  1.000 24.72415  ? 249 ILE A N    1 
ATOM   3794 C CA   . ILE A 1 249 ? 12.50011  18.13726 17.36228  1.000 22.33373  ? 249 ILE A CA   1 
ATOM   3795 C C    . ILE A 1 249 ? 12.01720  17.61702 18.71691  1.000 22.68976  ? 249 ILE A C    1 
ATOM   3796 O O    . ILE A 1 249 ? 11.64139  18.40067 19.59463  1.000 26.44923  ? 249 ILE A O    1 
ATOM   3797 C CB   . ILE A 1 249 ? 11.33398  18.25717 16.35230  1.000 25.26651  ? 249 ILE A CB   1 
ATOM   3798 C CG1  . ILE A 1 249 ? 11.74027  19.18987 15.20250  1.000 28.14843  ? 249 ILE A CG1  1 
ATOM   3799 C CG2  . ILE A 1 249 ? 10.08498  18.75923 17.02571  1.000 31.03894  ? 249 ILE A CG2  1 
ATOM   3800 C CD1  . ILE A 1 249 ? 10.87443  19.04430 13.95589  1.000 38.40260  ? 249 ILE A CD1  1 
ATOM   3801 H H    . ILE A 1 249 ? 13.29347  16.91160 16.03287  1.000 29.66898  ? 249 ILE A H    1 
ATOM   3802 H HA   . ILE A 1 249 ? 12.88315  19.01414 17.52128  1.000 26.80047  ? 249 ILE A HA   1 
ATOM   3803 H HB   . ILE A 1 249 ? 11.14458  17.37547 15.99505  1.000 30.31981  ? 249 ILE A HB   1 
ATOM   3804 H HG12 . ILE A 1 249 ? 11.66920  20.10831 15.50634  1.000 33.77811  ? 249 ILE A HG12 1 
ATOM   3805 H HG13 . ILE A 1 249 ? 12.65629  18.99360 14.95091  1.000 33.77811  ? 249 ILE A HG13 1 
ATOM   3806 H HG21 . ILE A 1 249 ? 9.45369   19.04558 16.34721  1.000 37.24673  ? 249 ILE A HG21 1 
ATOM   3807 H HG22 . ILE A 1 249 ? 9.70060   18.04186 17.55348  1.000 37.24673  ? 249 ILE A HG22 1 
ATOM   3808 H HG23 . ILE A 1 249 ? 10.31450  19.50625 17.60033  1.000 37.24673  ? 249 ILE A HG23 1 
ATOM   3809 H HD11 . ILE A 1 249 ? 10.79325  18.10307 13.73592  1.000 46.08312  ? 249 ILE A HD11 1 
ATOM   3810 H HD12 . ILE A 1 249 ? 9.99778   19.41899 14.13476  1.000 46.08312  ? 249 ILE A HD12 1 
ATOM   3811 H HD13 . ILE A 1 249 ? 11.29426  19.52040 13.22243  1.000 46.08312  ? 249 ILE A HD13 1 
ATOM   3812 N N    . LEU A 1 250 ? 12.03041  16.31605 18.90401  1.000 22.55782  ? 250 LEU A N    1 
ATOM   3813 C CA   . LEU A 1 250 ? 11.59712  15.71496 20.16295  1.000 22.35205  ? 250 LEU A CA   1 
ATOM   3814 C C    . LEU A 1 250 ? 12.69145  15.71920 21.22452  1.000 28.15723  ? 250 LEU A C    1 
ATOM   3815 O O    . LEU A 1 250 ? 12.40673  15.36288 22.36936  1.000 26.49932  ? 250 LEU A O    1 
ATOM   3816 C CB   . LEU A 1 250 ? 11.11566  14.29149 19.90739  1.000 21.01502  ? 250 LEU A CB   1 
ATOM   3817 C CG   . LEU A 1 250 ? 9.78408   14.19197 19.16676  1.000 19.41789  ? 250 LEU A CG   1 
ATOM   3818 C CD1  . LEU A 1 250 ? 9.57357   12.77963 18.72755  1.000 21.05160  ? 250 LEU A CD1  1 
ATOM   3819 C CD2  . LEU A 1 250 ? 8.62172   14.66924 20.06906  1.000 22.67778  ? 250 LEU A CD2  1 
ATOM   3820 H H    . LEU A 1 250 ? 12.28773  15.74465 18.31503  1.000 27.06939  ? 250 LEU A H    1 
ATOM   3821 H HA   . LEU A 1 250 ? 10.84944  16.21961 20.51961  1.000 26.82246  ? 250 LEU A HA   1 
ATOM   3822 H HB2  . LEU A 1 250 ? 11.78276  13.83240 19.37343  1.000 25.21802  ? 250 LEU A HB2  1 
ATOM   3823 H HB3  . LEU A 1 250 ? 11.00963  13.84465 20.76179  1.000 25.21802  ? 250 LEU A HB3  1 
ATOM   3824 H HG   . LEU A 1 250 ? 9.79549   14.76524 18.38437  1.000 23.30147  ? 250 LEU A HG   1 
ATOM   3825 H HD11 . LEU A 1 250 ? 10.27490  12.53505 18.10368  1.000 25.26192  ? 250 LEU A HD11 1 
ATOM   3826 H HD12 . LEU A 1 250 ? 9.60466   12.19940 19.50426  1.000 25.26192  ? 250 LEU A HD12 1 
ATOM   3827 H HD13 . LEU A 1 250 ? 8.70766   12.70878 18.29620  1.000 25.26192  ? 250 LEU A HD13 1 
ATOM   3828 H HD21 . LEU A 1 250 ? 7.77953   14.46950 19.63121  1.000 27.21334  ? 250 LEU A HD21 1 
ATOM   3829 H HD22 . LEU A 1 250 ? 8.67079   14.20491 20.91929  1.000 27.21334  ? 250 LEU A HD22 1 
ATOM   3830 H HD23 . LEU A 1 250 ? 8.70298   15.62561 20.20929  1.000 27.21334  ? 250 LEU A HD23 1 
ATOM   3831 N N    . GLY A 1 251 ? 13.90786  16.13842 20.88128  1.000 31.33048  ? 251 GLY A N    1 
ATOM   3832 C CA   . GLY A 1 251 ? 15.02931  16.12525 21.79549  1.000 30.24480  ? 251 GLY A CA   1 
ATOM   3833 C C    . GLY A 1 251 ? 14.74853  16.74072 23.14751  1.000 29.78357  ? 251 GLY A C    1 
ATOM   3834 O O    . GLY A 1 251 ? 14.99017  16.12568 24.18932  1.000 27.68829  ? 251 GLY A O    1 
ATOM   3835 H H    . GLY A 1 251 ? 14.10746  16.44205 20.10182  1.000 37.59657  ? 251 GLY A H    1 
ATOM   3836 H HA2  . GLY A 1 251 ? 15.30339  15.20608 21.94010  1.000 36.29377  ? 251 GLY A HA2  1 
ATOM   3837 H HA3  . GLY A 1 251 ? 15.76460  16.61470 21.39464  1.000 36.29377  ? 251 GLY A HA3  1 
ATOM   3838 N N    . PRO A 1 252 ? 14.23615  17.97579 23.16722  1.000 31.75346  ? 252 PRO A N    1 
ATOM   3839 C CA   . PRO A 1 252 ? 13.95122  18.62053 24.45822  1.000 30.83587  ? 252 PRO A CA   1 
ATOM   3840 C C    . PRO A 1 252 ? 13.00966  17.82682 25.35217  1.000 33.69408  ? 252 PRO A C    1 
ATOM   3841 O O    . PRO A 1 252 ? 13.23514  17.72975 26.56595  1.000 29.17225  ? 252 PRO A O    1 
ATOM   3842 C CB   . PRO A 1 252 ? 13.36391  19.97562 24.05426  1.000 35.45223  ? 252 PRO A CB   1 
ATOM   3843 C CG   . PRO A 1 252 ? 13.96908  20.24497 22.69437  1.000 33.14194  ? 252 PRO A CG   1 
ATOM   3844 C CD   . PRO A 1 252 ? 14.08665  18.90410 22.02804  1.000 35.90393  ? 252 PRO A CD   1 
ATOM   3845 H HA   . PRO A 1 252 ? 14.78377  18.76416 24.93480  1.000 37.00304  ? 252 PRO A HA   1 
ATOM   3846 H HB2  . PRO A 1 252 ? 12.39692  19.91901 24.00304  1.000 42.54268  ? 252 PRO A HB2  1 
ATOM   3847 H HB3  . PRO A 1 252 ? 13.62291  20.65655 24.69470  1.000 42.54268  ? 252 PRO A HB3  1 
ATOM   3848 H HG2  . PRO A 1 252 ? 13.38649  20.83138 22.18682  1.000 39.77033  ? 252 PRO A HG2  1 
ATOM   3849 H HG3  . PRO A 1 252 ? 14.84207  20.65453 22.79954  1.000 39.77033  ? 252 PRO A HG3  1 
ATOM   3850 H HD2  . PRO A 1 252 ? 13.28719  18.69996 21.51806  1.000 43.08472  ? 252 PRO A HD2  1 
ATOM   3851 H HD3  . PRO A 1 252 ? 14.86560  18.87173 21.45090  1.000 43.08472  ? 252 PRO A HD3  1 
ATOM   3852 N N    . LEU A 1 253 ? 11.95395  17.24440 24.79292  1.000 23.79015  ? 253 LEU A N    1 
ATOM   3853 C CA   . LEU A 1 253 ? 11.05512  16.42358 25.58261  1.000 18.23531  ? 253 LEU A CA   1 
ATOM   3854 C C    . LEU A 1 253 ? 11.74086  15.13651 26.04187  1.000 23.71316  ? 253 LEU A C    1 
ATOM   3855 O O    . LEU A 1 253 ? 11.52973  14.68540 27.17772  1.000 21.59064  ? 253 LEU A O    1 
ATOM   3856 C CB   . LEU A 1 253 ? 9.79384   16.09659 24.79112  1.000 22.86835  ? 253 LEU A CB   1 
ATOM   3857 C CG   . LEU A 1 253 ? 8.83214   17.27471 24.61424  1.000 22.13564  ? 253 LEU A CG   1 
ATOM   3858 C CD1  . LEU A 1 253 ? 7.73662   16.93282 23.63272  1.000 20.43542  ? 253 LEU A CD1  1 
ATOM   3859 C CD2  . LEU A 1 253 ? 8.20991   17.66523 25.93898  1.000 23.20133  ? 253 LEU A CD2  1 
ATOM   3860 H H    . LEU A 1 253 ? 11.73921  17.30983 23.96274  1.000 28.54818  ? 253 LEU A H    1 
ATOM   3861 H HA   . LEU A 1 253 ? 10.79141  16.92805 26.36802  1.000 21.88237  ? 253 LEU A HA   1 
ATOM   3862 H HB2  . LEU A 1 253 ? 10.05435  15.79487 23.90681  1.000 27.44202  ? 253 LEU A HB2  1 
ATOM   3863 H HB3  . LEU A 1 253 ? 9.31344   15.39229 25.25380  1.000 27.44202  ? 253 LEU A HB3  1 
ATOM   3864 H HG   . LEU A 1 253 ? 9.33825   18.02719 24.26997  1.000 26.56277  ? 253 LEU A HG   1 
ATOM   3865 H HD11 . LEU A 1 253 ? 7.21571   16.19448 23.98543  1.000 24.52250  ? 253 LEU A HD11 1 
ATOM   3866 H HD12 . LEU A 1 253 ? 7.16866   17.70955 23.51021  1.000 24.52250  ? 253 LEU A HD12 1 
ATOM   3867 H HD13 . LEU A 1 253 ? 8.13818   16.67994 22.78673  1.000 24.52250  ? 253 LEU A HD13 1 
ATOM   3868 H HD21 . LEU A 1 253 ? 7.87211   16.86809 26.37642  1.000 27.84160  ? 253 LEU A HD21 1 
ATOM   3869 H HD22 . LEU A 1 253 ? 8.88563   18.08570 26.49352  1.000 27.84160  ? 253 LEU A HD22 1 
ATOM   3870 H HD23 . LEU A 1 253 ? 7.48283   18.28615 25.77554  1.000 27.84160  ? 253 LEU A HD23 1 
ATOM   3871 N N    . SER A 1 254 ? 12.56113  14.54962 25.18176  1.000 25.54297  ? 254 SER A N    1 
ATOM   3872 C CA   A SER A 1 254 ? 13.34779  13.38725 25.57300  0.790 24.22521  ? 254 SER A CA   1 
ATOM   3873 C CA   B SER A 1 254 ? 13.34877  13.38805 25.57396  0.210 24.31817  ? 254 SER A CA   1 
ATOM   3874 C C    . SER A 1 254 ? 14.29915  13.72661 26.71827  1.000 26.23601  ? 254 SER A C    1 
ATOM   3875 O O    . SER A 1 254 ? 14.44691  12.93952 27.67466  1.000 25.78357  ? 254 SER A O    1 
ATOM   3876 C CB   . SER A 1 254 ? 14.13042  12.87395 24.36637  1.000 28.46068  ? 254 SER A CB   1 
ATOM   3877 O OG   . SER A 1 254 ? 14.99027  11.80886 24.73287  1.000 35.53032  ? 254 SER A OG   1 
ATOM   3878 H H    A SER A 1 254 ? 12.68166  14.80201 24.36851  0.790 30.65157  ? 254 SER A H    1 
ATOM   3879 H H    B SER A 1 254 ? 12.68111  14.80141 24.36824  0.210 30.65157  ? 254 SER A H    1 
ATOM   3880 H HA   A SER A 1 254 ? 12.75113  12.68515 25.87626  0.790 29.07025  ? 254 SER A HA   1 
ATOM   3881 H HA   B SER A 1 254 ? 12.75260  12.68615 25.87861  0.210 29.18181  ? 254 SER A HA   1 
ATOM   3882 H HB2  A SER A 1 254 ? 13.50441  12.55708 23.69659  0.790 34.15282  ? 254 SER A HB2  1 
ATOM   3883 H HB2  B SER A 1 254 ? 13.50377  12.55689 23.69728  0.210 34.15282  ? 254 SER A HB2  1 
ATOM   3884 H HB3  A SER A 1 254 ? 14.66376  13.59922 24.00523  0.790 34.15282  ? 254 SER A HB3  1 
ATOM   3885 H HB3  B SER A 1 254 ? 14.66362  13.59892 24.00441  0.210 34.15282  ? 254 SER A HB3  1 
ATOM   3886 H HG   A SER A 1 254 ? 14.55297  11.09416 24.79267  0.790 42.63638  ? 254 SER A HG   1 
ATOM   3887 H HG   B SER A 1 254 ? 15.70116  11.84711 24.28703  0.210 42.63638  ? 254 SER A HG   1 
ATOM   3888 N N    . ALA A 1 255 ? 14.93879  14.89512 26.65550  1.000 24.46251  ? 255 ALA A N    1 
ATOM   3889 C CA   . ALA A 1 255 ? 15.86495  15.28741 27.72342  1.000 33.12695  ? 255 ALA A CA   1 
ATOM   3890 C C    . ALA A 1 255 ? 15.12572  15.50359 29.03234  1.000 39.80418  ? 255 ALA A C    1 
ATOM   3891 O O    . ALA A 1 255 ? 15.59045  15.07290 30.10533  1.000 32.22940  ? 255 ALA A O    1 
ATOM   3892 C CB   . ALA A 1 255 ? 16.61291  16.56450 27.32088  1.000 33.75104  ? 255 ALA A CB   1 
ATOM   3893 H H    . ALA A 1 255 ? 14.85785  15.46889 26.02001  1.000 29.35501  ? 255 ALA A H    1 
ATOM   3894 H HA   . ALA A 1 255 ? 16.51569  14.57971 27.85222  1.000 39.75234  ? 255 ALA A HA   1 
ATOM   3895 H HB1  . ALA A 1 255 ? 17.26323  16.77940 28.00776  1.000 40.50125  ? 255 ALA A HB1  1 
ATOM   3896 H HB2  . ALA A 1 255 ? 17.06291  16.41357 26.47494  1.000 40.50125  ? 255 ALA A HB2  1 
ATOM   3897 H HB3  . ALA A 1 255 ? 15.97461  17.28938 27.23130  1.000 40.50125  ? 255 ALA A HB3  1 
ATOM   3898 N N    . GLN A 1 256 ? 13.96689  16.15857 28.96920  1.000 25.77854  ? 256 GLN A N    1 
ATOM   3899 C CA   . GLN A 1 256 ? 13.23068  16.47256 30.18272  1.000 26.24231  ? 256 GLN A CA   1 
ATOM   3900 C C    . GLN A 1 256 ? 12.79073  15.21007 30.91260  1.000 29.89060  ? 256 GLN A C    1 
ATOM   3901 O O    . GLN A 1 256 ? 12.80238  15.16293 32.14634  1.000 30.93247  ? 256 GLN A O    1 
ATOM   3902 C CB   . GLN A 1 256 ? 12.02696  17.34658 29.84480  1.000 27.69149  ? 256 GLN A CB   1 
ATOM   3903 C CG   . GLN A 1 256 ? 11.15459  17.66242 31.02103  1.000 33.10403  ? 256 GLN A CG   1 
ATOM   3904 C CD   . GLN A 1 256 ? 10.03657  18.60505 30.68955  1.000 36.97188  ? 256 GLN A CD   1 
ATOM   3905 O OE1  . GLN A 1 256 ? 9.99128   19.19042 29.59726  1.000 42.67352  ? 256 GLN A OE1  1 
ATOM   3906 N NE2  . GLN A 1 256 ? 9.12348   18.75200 31.60598  1.000 29.75035  ? 256 GLN A NE2  1 
ATOM   3907 H H    . GLN A 1 256 ? 13.59223  16.42779 28.24342  1.000 30.93425  ? 256 GLN A H    1 
ATOM   3908 H HA   . GLN A 1 256 ? 13.81024  16.97066 30.78013  1.000 31.49077  ? 256 GLN A HA   1 
ATOM   3909 H HB2  . GLN A 1 256 ? 12.34555  18.18679 29.47948  1.000 33.22979  ? 256 GLN A HB2  1 
ATOM   3910 H HB3  . GLN A 1 256 ? 11.48192  16.88490 29.18854  1.000 33.22979  ? 256 GLN A HB3  1 
ATOM   3911 H HG2  . GLN A 1 256 ? 10.76245  16.83923 31.35191  1.000 39.72484  ? 256 GLN A HG2  1 
ATOM   3912 H HG3  . GLN A 1 256 ? 11.69607  18.07351 31.71292  1.000 39.72484  ? 256 GLN A HG3  1 
ATOM   3913 H HE21 . GLN A 1 256 ? 9.18506   18.32063 32.34742  1.000 35.70042  ? 256 GLN A HE21 1 
ATOM   3914 H HE22 . GLN A 1 256 ? 8.45878   19.28044 31.46987  1.000 35.70042  ? 256 GLN A HE22 1 
ATOM   3915 N N    . THR A 1 257 ? 12.35765  14.19926 30.18153  1.000 24.25383  ? 257 THR A N    1 
ATOM   3916 C CA   . THR A 1 257 ? 11.85537  12.97001 30.76031  1.000 24.58350  ? 257 THR A CA   1 
ATOM   3917 C C    . THR A 1 257 ? 12.92557  11.88696 30.93562  1.000 25.90776  ? 257 THR A C    1 
ATOM   3918 O O    . THR A 1 257 ? 12.67116  10.91613 31.64572  1.000 28.01669  ? 257 THR A O    1 
ATOM   3919 C CB   . THR A 1 257 ? 10.74042  12.37003 29.90308  1.000 22.63548  ? 257 THR A CB   1 
ATOM   3920 O OG1  . THR A 1 257 ? 11.25565  12.07393 28.58186  1.000 24.27553  ? 257 THR A OG1  1 
ATOM   3921 C CG2  . THR A 1 257 ? 9.58406   13.36156 29.78006  1.000 21.91537  ? 257 THR A CG2  1 
ATOM   3922 H H    . THR A 1 257 ? 12.34434  14.20158 29.32164  1.000 29.10460  ? 257 THR A H    1 
ATOM   3923 H HA   . THR A 1 257 ? 11.49286  13.20089 31.62990  1.000 29.50020  ? 257 THR A HA   1 
ATOM   3924 H HB   . THR A 1 257 ? 10.41127  11.55493 30.31317  1.000 27.16258  ? 257 THR A HB   1 
ATOM   3925 H HG1  . THR A 1 257 ? 11.59092  11.30383 28.57017  1.000 29.13064  ? 257 THR A HG1  1 
ATOM   3926 H HG21 . THR A 1 257 ? 9.84231   14.22004 30.15048  1.000 26.29845  ? 257 THR A HG21 1 
ATOM   3927 H HG22 . THR A 1 257 ? 9.34636   13.47993 28.84711  1.000 26.29845  ? 257 THR A HG22 1 
ATOM   3928 H HG23 . THR A 1 257 ? 8.81039   13.03046 30.26246  1.000 26.29845  ? 257 THR A HG23 1 
ATOM   3929 N N    . GLY A 1 258 ? 14.08146  12.03194 30.29942  1.000 26.02774  ? 258 GLY A N    1 
ATOM   3930 C CA   . GLY A 1 258 ? 15.08541  10.99499 30.30339  1.000 29.06978  ? 258 GLY A CA   1 
ATOM   3931 C C    . GLY A 1 258 ? 14.74460  9.75925  29.51597  1.000 34.94365  ? 258 GLY A C    1 
ATOM   3932 O O    . GLY A 1 258 ? 15.34354  8.70960  29.73013  1.000 30.27881  ? 258 GLY A O    1 
ATOM   3933 H H    . GLY A 1 258 ? 14.30613  12.73245 29.85399  1.000 31.23329  ? 258 GLY A H    1 
ATOM   3934 H HA2  . GLY A 1 258 ? 15.90588  11.35929 29.93595  1.000 34.88373  ? 258 GLY A HA2  1 
ATOM   3935 H HA3  . GLY A 1 258 ? 15.24370  10.72310 31.22096  1.000 34.88373  ? 258 GLY A HA3  1 
ATOM   3936 N N    . ILE A 1 259 ? 13.78641  9.84186  28.59737  1.000 25.90113  ? 259 ILE A N    1 
ATOM   3937 C CA   . ILE A 1 259 ? 13.39542  8.70572  27.77358  1.000 25.34357  ? 259 ILE A CA   1 
ATOM   3938 C C    . ILE A 1 259 ? 13.81680  9.02352  26.35096  1.000 28.19683  ? 259 ILE A C    1 
ATOM   3939 O O    . ILE A 1 259 ? 13.32715  9.99709  25.75764  1.000 24.25146  ? 259 ILE A O    1 
ATOM   3940 C CB   . ILE A 1 259 ? 11.88882  8.42694  27.85858  1.000 25.26148  ? 259 ILE A CB   1 
ATOM   3941 C CG1  . ILE A 1 259 ? 11.50017  8.08385  29.30988  1.000 25.75887  ? 259 ILE A CG1  1 
ATOM   3942 C CG2  . ILE A 1 259 ? 11.49692  7.31802  26.92979  1.000 22.57320  ? 259 ILE A CG2  1 
ATOM   3943 C CD1  . ILE A 1 259 ? 10.05131  8.16142  29.56091  1.000 31.28034  ? 259 ILE A CD1  1 
ATOM   3944 H H    . ILE A 1 259 ? 13.34172  10.55905 28.43158  1.000 31.08136  ? 259 ILE A H    1 
ATOM   3945 H HA   . ILE A 1 259 ? 13.86074  7.90828  28.07101  1.000 30.41228  ? 259 ILE A HA   1 
ATOM   3946 H HB   . ILE A 1 259 ? 11.41274  9.22708  27.58653  1.000 30.31377  ? 259 ILE A HB   1 
ATOM   3947 H HG12 . ILE A 1 259 ? 11.78810  7.17849  29.50566  1.000 30.91065  ? 259 ILE A HG12 1 
ATOM   3948 H HG13 . ILE A 1 259 ? 11.93970  8.70840  29.90793  1.000 30.91065  ? 259 ILE A HG13 1 
ATOM   3949 H HG21 . ILE A 1 259 ? 12.09435  6.56606  27.06593  1.000 27.08784  ? 259 ILE A HG21 1 
ATOM   3950 H HG22 . ILE A 1 259 ? 10.58349  7.05366  27.12127  1.000 27.08784  ? 259 ILE A HG22 1 
ATOM   3951 H HG23 . ILE A 1 259 ? 11.56517  7.63331  26.01500  1.000 27.08784  ? 259 ILE A HG23 1 
ATOM   3952 H HD11 . ILE A 1 259 ? 9.74825   9.06585  29.38468  1.000 37.53640  ? 259 ILE A HD11 1 
ATOM   3953 H HD12 . ILE A 1 259 ? 9.59517   7.53925  28.97291  1.000 37.53640  ? 259 ILE A HD12 1 
ATOM   3954 H HD13 . ILE A 1 259 ? 9.87831   7.92907  30.48664  1.000 37.53640  ? 259 ILE A HD13 1 
ATOM   3955 N N    . ALA A 1 260 ? 14.75478  8.23890  25.82706  1.000 25.07093  ? 260 ALA A N    1 
ATOM   3956 C CA   . ALA A 1 260 ? 15.25248  8.47875  24.47837  1.000 29.08058  ? 260 ALA A CA   1 
ATOM   3957 C C    . ALA A 1 260 ? 14.12469  8.33087  23.46286  1.000 23.50225  ? 260 ALA A C    1 
ATOM   3958 O O    . ALA A 1 260 ? 13.19510  7.54195  23.63668  1.000 20.25721  ? 260 ALA A O    1 
ATOM   3959 C CB   . ALA A 1 260 ? 16.38109  7.48956  24.15348  1.000 33.99794  ? 260 ALA A CB   1 
ATOM   3960 H H    . ALA A 1 260 ? 15.11507  7.56864  26.22774  1.000 30.08512  ? 260 ALA A H    1 
ATOM   3961 H HA   . ALA A 1 260 ? 15.60531  9.38005  24.41455  1.000 34.89670  ? 260 ALA A HA   1 
ATOM   3962 H HB1  . ALA A 1 260 ? 16.68707  7.64635  23.24646  1.000 40.79753  ? 260 ALA A HB1  1 
ATOM   3963 H HB2  . ALA A 1 260 ? 17.11103  7.62729  24.77728  1.000 40.79753  ? 260 ALA A HB2  1 
ATOM   3964 H HB3  . ALA A 1 260 ? 16.04151  6.58472  24.23626  1.000 40.79753  ? 260 ALA A HB3  1 
ATOM   3965 N N    . VAL A 1 261 ? 14.22404  9.10514  22.37540  1.000 24.02225  ? 261 VAL A N    1 
ATOM   3966 C CA   . VAL A 1 261 ? 13.16674  9.08962  21.36790  1.000 21.87065  ? 261 VAL A CA   1 
ATOM   3967 C C    . VAL A 1 261 ? 12.92033  7.67711  20.86745  1.000 20.49768  ? 261 VAL A C    1 
ATOM   3968 O O    . VAL A 1 261 ? 11.78716  7.22571  20.77200  1.000 21.01442  ? 261 VAL A O    1 
ATOM   3969 C CB   . VAL A 1 261 ? 13.47999  10.07510 20.23050  1.000 22.86372  ? 261 VAL A CB   1 
ATOM   3970 C CG1  . VAL A 1 261 ? 12.41868  9.96451  19.14175  1.000 24.28215  ? 261 VAL A CG1  1 
ATOM   3971 C CG2  . VAL A 1 261 ? 13.58205  11.48184 20.75238  1.000 24.95750  ? 261 VAL A CG2  1 
ATOM   3972 H H    . VAL A 1 261 ? 14.87941  9.63500  22.20413  1.000 28.82670  ? 261 VAL A H    1 
ATOM   3973 H HA   . VAL A 1 261 ? 12.34386  9.38968  21.78471  1.000 26.24478  ? 261 VAL A HA   1 
ATOM   3974 H HB   . VAL A 1 261 ? 14.33954  9.85090  19.84088  1.000 27.43647  ? 261 VAL A HB   1 
ATOM   3975 H HG11 . VAL A 1 261 ? 12.48220  10.73745 18.55914  1.000 29.13857  ? 261 VAL A HG11 1 
ATOM   3976 H HG12 . VAL A 1 261 ? 12.57181  9.15313  18.63271  1.000 29.13857  ? 261 VAL A HG12 1 
ATOM   3977 H HG13 . VAL A 1 261 ? 11.54247  9.93423  19.55676  1.000 29.13857  ? 261 VAL A HG13 1 
ATOM   3978 H HG21 . VAL A 1 261 ? 13.72978  12.08514 20.00732  1.000 29.94900  ? 261 VAL A HG21 1 
ATOM   3979 H HG22 . VAL A 1 261 ? 12.75547  11.71148 21.20507  1.000 29.94900  ? 261 VAL A HG22 1 
ATOM   3980 H HG23 . VAL A 1 261 ? 14.32519  11.53511 21.37351  1.000 29.94900  ? 261 VAL A HG23 1 
ATOM   3981 N N    . LEU A 1 262 ? 13.99012  6.93301  20.54458  1.000 22.81299  ? 262 LEU A N    1 
ATOM   3982 C CA   . LEU A 1 262 ? 13.79296  5.59047  20.02063  1.000 28.14287  ? 262 LEU A CA   1 
ATOM   3983 C C    . LEU A 1 262 ? 13.26737  4.61216  21.06045  1.000 24.40393  ? 262 LEU A C    1 
ATOM   3984 O O    . LEU A 1 262 ? 12.65954  3.60385  20.68590  1.000 25.46609  ? 262 LEU A O    1 
ATOM   3985 C CB   . LEU A 1 262 ? 15.09663  5.08531  19.36052  1.000 28.85110  ? 262 LEU A CB   1 
ATOM   3986 C CG   . LEU A 1 262 ? 15.41046  5.81986  18.03649  1.000 27.13253  ? 262 LEU A CG   1 
ATOM   3987 C CD1  . LEU A 1 262 ? 16.80306  5.43367  17.58126  1.000 38.79033  ? 262 LEU A CD1  1 
ATOM   3988 C CD2  . LEU A 1 262 ? 14.39383  5.49887  16.95117  1.000 29.05815  ? 262 LEU A CD2  1 
ATOM   3989 H H    . LEU A 1 262 ? 14.80996  7.18156  20.62001  1.000 27.37558  ? 262 LEU A H    1 
ATOM   3990 H HA   . LEU A 1 262 ? 13.11808  5.62147  19.32459  1.000 33.77144  ? 262 LEU A HA   1 
ATOM   3991 H HB2  . LEU A 1 262 ? 15.83695  5.23115  19.97008  1.000 34.62132  ? 262 LEU A HB2  1 
ATOM   3992 H HB3  . LEU A 1 262 ? 15.00732  4.13891  19.16749  1.000 34.62132  ? 262 LEU A HB3  1 
ATOM   3993 H HG   . LEU A 1 262 ? 15.36407  6.77696  18.18716  1.000 32.55904  ? 262 LEU A HG   1 
ATOM   3994 H HD11 . LEU A 1 262 ? 17.03239  5.95062  16.79318  1.000 46.54839  ? 262 LEU A HD11 1 
ATOM   3995 H HD12 . LEU A 1 262 ? 17.43225  5.62208  18.29507  1.000 46.54839  ? 262 LEU A HD12 1 
ATOM   3996 H HD13 . LEU A 1 262 ? 16.81532  4.48684  17.37087  1.000 46.54839  ? 262 LEU A HD13 1 
ATOM   3997 H HD21 . LEU A 1 262 ? 14.71249  5.85169  16.10566  1.000 34.86977  ? 262 LEU A HD21 1 
ATOM   3998 H HD22 . LEU A 1 262 ? 14.29042  4.53634  16.89003  1.000 34.86977  ? 262 LEU A HD22 1 
ATOM   3999 H HD23 . LEU A 1 262 ? 13.54549  5.90870  17.18194  1.000 34.86977  ? 262 LEU A HD23 1 
ATOM   4000 N N    . ASP A 1 263 ? 13.44187  4.90037  22.35997  1.000 23.59394  ? 263 ASP A N    1 
ATOM   4001 C CA   . ASP A 1 263 ? 12.77569  4.11274  23.38469  1.000 24.98765  ? 263 ASP A CA   1 
ATOM   4002 C C    . ASP A 1 263 ? 11.27436  4.38630  23.38396  1.000 21.64945  ? 263 ASP A C    1 
ATOM   4003 O O    . ASP A 1 263 ? 10.46388  3.45956  23.45807  1.000 22.72370  ? 263 ASP A O    1 
ATOM   4004 C CB   . ASP A 1 263 ? 13.34266  4.43231  24.76164  1.000 29.60921  ? 263 ASP A CB   1 
ATOM   4005 C CG   . ASP A 1 263 ? 14.74004  3.87604  24.96995  1.000 47.40866  ? 263 ASP A CG   1 
ATOM   4006 O OD1  . ASP A 1 263 ? 15.31277  3.30439  24.00899  1.000 38.44951  ? 263 ASP A OD1  1 
ATOM   4007 O OD2  . ASP A 1 263 ? 15.25964  4.01455  26.10056  1.000 43.13998  ? 263 ASP A OD2  1 
ATOM   4008 H H    . ASP A 1 263 ? 13.93422  5.53777  22.66148  1.000 28.31273  ? 263 ASP A H    1 
ATOM   4009 H HA   . ASP A 1 263 ? 12.93499  3.17417  23.19869  1.000 29.98518  ? 263 ASP A HA   1 
ATOM   4010 H HB2  . ASP A 1 263 ? 13.38487  5.39536  24.86961  1.000 35.53106  ? 263 ASP A HB2  1 
ATOM   4011 H HB3  . ASP A 1 263 ? 12.76363  4.04769  25.43817  1.000 35.53106  ? 263 ASP A HB3  1 
ATOM   4012 N N    . MET A 1 264 ? 10.89267  5.65502  23.24797  1.000 21.35180  ? 264 MET A N    1 
ATOM   4013 C CA   . MET A 1 264 ? 9.46791   5.96469  23.12454  1.000 21.93764  ? 264 MET A CA   1 
ATOM   4014 C C    . MET A 1 264 ? 8.87790   5.36185  21.86250  1.000 22.16300  ? 264 MET A C    1 
ATOM   4015 O O    . MET A 1 264 ? 7.71496   4.95004  21.84646  1.000 24.48083  ? 264 MET A O    1 
ATOM   4016 C CB   . MET A 1 264 ? 9.27183   7.48390  23.16914  1.000 19.11117  ? 264 MET A CB   1 
ATOM   4017 C CG   . MET A 1 264 ? 7.79070   7.87425  23.40590  1.000 21.07342  ? 264 MET A CG   1 
ATOM   4018 S SD   . MET A 1 264 ? 7.20033   7.37843  25.05887  1.000 21.82485  ? 264 MET A SD   1 
ATOM   4019 C CE   . MET A 1 264 ? 7.69559   8.81411  25.99821  1.000 20.44785  ? 264 MET A CE   1 
ATOM   4020 H H    . MET A 1 264 ? 11.41980  6.33413  23.22474  1.000 25.62216  ? 264 MET A H    1 
ATOM   4021 H HA   . MET A 1 264 ? 8.98857   5.59085  23.88044  1.000 26.32517  ? 264 MET A HA   1 
ATOM   4022 H HB2  . MET A 1 264 ? 9.80180   7.85196  23.89341  1.000 22.93340  ? 264 MET A HB2  1 
ATOM   4023 H HB3  . MET A 1 264 ? 9.55461   7.86613  22.32366  1.000 22.93340  ? 264 MET A HB3  1 
ATOM   4024 H HG2  . MET A 1 264 ? 7.69947   8.83688  23.32889  1.000 25.28810  ? 264 MET A HG2  1 
ATOM   4025 H HG3  . MET A 1 264 ? 7.23613   7.43434  22.74270  1.000 25.28810  ? 264 MET A HG3  1 
ATOM   4026 H HE1  . MET A 1 264 ? 8.63178   8.99829  25.82347  1.000 24.53743  ? 264 MET A HE1  1 
ATOM   4027 H HE2  . MET A 1 264 ? 7.15331   9.57132  25.72717  1.000 24.53743  ? 264 MET A HE2  1 
ATOM   4028 H HE3  . MET A 1 264 ? 7.56445   8.63441  26.94236  1.000 24.53743  ? 264 MET A HE3  1 
ATOM   4029 N N    . CYS A 1 265 ? 9.66273   5.28000  20.77664  1.000 22.03325  ? 265 CYS A N    1 
ATOM   4030 C CA   . CYS A 1 265 ? 9.17253   4.60815  19.58158  1.000 20.97244  ? 265 CYS A CA   1 
ATOM   4031 C C    . CYS A 1 265 ? 8.87933   3.13146  19.83382  1.000 19.52249  ? 265 CYS A C    1 
ATOM   4032 O O    . CYS A 1 265 ? 7.90121   2.59065  19.32428  1.000 22.25397  ? 265 CYS A O    1 
ATOM   4033 C CB   . CYS A 1 265 ? 10.18735  4.74623  18.43455  1.000 24.58172  ? 265 CYS A CB   1 
ATOM   4034 S SG   . CYS A 1 265 ? 10.29840  6.39395  17.73575  1.000 23.59388  ? 265 CYS A SG   1 
ATOM   4035 H H    . CYS A 1 265 ? 10.45923  5.59838  20.71484  1.000 26.43990  ? 265 CYS A H    1 
ATOM   4036 H HA   . CYS A 1 265 ? 8.34500   5.04067  19.31885  1.000 25.16693  ? 265 CYS A HA   1 
ATOM   4037 H HB2  . CYS A 1 265 ? 11.06644  4.50998  18.76965  1.000 29.49806  ? 265 CYS A HB2  1 
ATOM   4038 H HB3  . CYS A 1 265 ? 9.93092   4.14164  17.72068  1.000 29.49806  ? 265 CYS A HB3  1 
ATOM   4039 H HG   . CYS A 1 265 ? 10.70343  7.14838  18.57646  1.000 28.31266  ? 265 CYS A HG   1 
ATOM   4040 N N    . ALA A 1 266 ? 9.71493   2.47028  20.64581  1.000 23.38487  ? 266 ALA A N    1 
ATOM   4041 C CA   . ALA A 1 266 ? 9.43774   1.08829  21.00607  1.000 25.08826  ? 266 ALA A CA   1 
ATOM   4042 C C    . ALA A 1 266 ? 8.13572   0.97541  21.78604  1.000 23.27714  ? 266 ALA A C    1 
ATOM   4043 O O    . ALA A 1 266 ? 7.36243   0.03832  21.58457  1.000 26.23107  ? 266 ALA A O    1 
ATOM   4044 C CB   . ALA A 1 266 ? 10.60487  0.51476  21.81580  1.000 30.10965  ? 266 ALA A CB   1 
ATOM   4045 H H    . ALA A 1 266 ? 10.43166  2.79727  20.99073  1.000 28.06184  ? 266 ALA A H    1 
ATOM   4046 H HA   . ALA A 1 266 ? 9.34822   0.56285  20.19564  1.000 30.10591  ? 266 ALA A HA   1 
ATOM   4047 H HB1  . ALA A 1 266 ? 10.43388  -0.42298 21.99552  1.000 36.13159  ? 266 ALA A HB1  1 
ATOM   4048 H HB2  . ALA A 1 266 ? 11.42225  0.60944  21.30216  1.000 36.13159  ? 266 ALA A HB2  1 
ATOM   4049 H HB3  . ALA A 1 266 ? 10.68028  1.00314  22.65048  1.000 36.13159  ? 266 ALA A HB3  1 
ATOM   4050 N N    . SER A 1 267 ? 7.86398   1.93710  22.68219  1.000 21.34472  ? 267 SER A N    1 
ATOM   4051 C CA   . SER A 1 267 ? 6.58357   1.94412  23.37279  1.000 19.09026  ? 267 SER A CA   1 
ATOM   4052 C C    . SER A 1 267 ? 5.43272   2.09643  22.40053  1.000 20.15951  ? 267 SER A C    1 
ATOM   4053 O O    . SER A 1 267 ? 4.40243   1.42400  22.51921  1.000 22.09697  ? 267 SER A O    1 
ATOM   4054 C CB   . SER A 1 267 ? 6.54118   3.08767  24.38113  1.000 23.84976  ? 267 SER A CB   1 
ATOM   4055 O OG   . SER A 1 267 ? 7.39803   2.82921  25.48181  1.000 27.42897  ? 267 SER A OG   1 
ATOM   4056 H H    . SER A 1 267 ? 8.39573   2.57770  22.89776  1.000 25.61366  ? 267 SER A H    1 
ATOM   4057 H HA   . SER A 1 267 ? 6.48761   1.10133  23.84333  1.000 22.90831  ? 267 SER A HA   1 
ATOM   4058 H HB2  . SER A 1 267 ? 6.82852   3.90420  23.94340  1.000 28.61971  ? 267 SER A HB2  1 
ATOM   4059 H HB3  . SER A 1 267 ? 5.63267   3.18743  24.70602  1.000 28.61971  ? 267 SER A HB3  1 
ATOM   4060 H HG   . SER A 1 267 ? 8.18043   2.68908  25.21012  1.000 32.91476  ? 267 SER A HG   1 
ATOM   4061 N N    . LEU A 1 268 ? 5.57808   3.00682  21.43887  1.000 21.94281  ? 268 LEU A N    1 
ATOM   4062 C CA   . LEU A 1 268 ? 4.50476   3.20565  20.46592  1.000 20.62750  ? 268 LEU A CA   1 
ATOM   4063 C C    . LEU A 1 268 ? 4.29449   1.95897  19.60945  1.000 18.53758  ? 268 LEU A C    1 
ATOM   4064 O O    . LEU A 1 268 ? 3.16043   1.58571  19.33076  1.000 21.60930  ? 268 LEU A O    1 
ATOM   4065 C CB   . LEU A 1 268 ? 4.81137   4.43521  19.60528  1.000 23.72344  ? 268 LEU A CB   1 
ATOM   4066 C CG   . LEU A 1 268 ? 3.79488   4.76186  18.52820  1.000 20.56207  ? 268 LEU A CG   1 
ATOM   4067 C CD1  . LEU A 1 268 ? 2.38762   4.84255  19.09776  1.000 20.33188  ? 268 LEU A CD1  1 
ATOM   4068 C CD2  . LEU A 1 268 ? 4.19051   6.07172  17.87383  1.000 19.59138  ? 268 LEU A CD2  1 
ATOM   4069 H H    . LEU A 1 268 ? 6.26793   3.50862  21.32976  1.000 26.33137  ? 268 LEU A H    1 
ATOM   4070 H HA   . LEU A 1 268 ? 3.67239   3.37480  20.93437  1.000 24.75300  ? 268 LEU A HA   1 
ATOM   4071 H HB2  . LEU A 1 268 ? 4.86866   5.20709  20.18993  1.000 28.46813  ? 268 LEU A HB2  1 
ATOM   4072 H HB3  . LEU A 1 268 ? 5.66234   4.29026  19.16285  1.000 28.46813  ? 268 LEU A HB3  1 
ATOM   4073 H HG   . LEU A 1 268 ? 3.78251   4.05689  17.86204  1.000 24.67448  ? 268 LEU A HG   1 
ATOM   4074 H HD11 . LEU A 1 268 ? 2.44206   4.94257  20.06105  1.000 24.39826  ? 268 LEU A HD11 1 
ATOM   4075 H HD12 . LEU A 1 268 ? 1.93374   5.60755  18.71090  1.000 24.39826  ? 268 LEU A HD12 1 
ATOM   4076 H HD13 . LEU A 1 268 ? 1.91009   4.02780  18.87627  1.000 24.39826  ? 268 LEU A HD13 1 
ATOM   4077 H HD21 . LEU A 1 268 ? 3.71879   6.15868  17.03073  1.000 23.50966  ? 268 LEU A HD21 1 
ATOM   4078 H HD22 . LEU A 1 268 ? 3.95186   6.80404  18.46346  1.000 23.50966  ? 268 LEU A HD22 1 
ATOM   4079 H HD23 . LEU A 1 268 ? 5.14800   6.07063  17.71856  1.000 23.50966  ? 268 LEU A HD23 1 
ATOM   4080 N N    . LYS A 1 269 ? 5.37713   1.31677  19.17995  1.000 21.03858  ? 269 LYS A N    1 
ATOM   4081 C CA   . LYS A 1 269 ? 5.25020   0.05109  18.44963  1.000 27.23084  ? 269 LYS A CA   1 
ATOM   4082 C C    . LYS A 1 269 ? 4.40367   -0.94403 19.22893  1.000 23.34607  ? 269 LYS A C    1 
ATOM   4083 O O    . LYS A 1 269 ? 3.48631   -1.56871 18.68622  1.000 26.95315  ? 269 LYS A O    1 
ATOM   4084 C CB   . LYS A 1 269 ? 6.64749   -0.51334 18.15711  1.000 24.90072  ? 269 LYS A CB   1 
ATOM   4085 C CG   . LYS A 1 269 ? 6.65541   -1.88816 17.51889  1.000 32.88398  ? 269 LYS A CG   1 
ATOM   4086 C CD   . LYS A 1 269 ? 8.08986   -2.35286 17.23306  1.000 42.01824  ? 269 LYS A CD   1 
ATOM   4087 C CE   . LYS A 1 269 ? 8.21730   -3.89143 17.20791  1.000 59.20150  ? 269 LYS A CE   1 
ATOM   4088 N NZ   . LYS A 1 269 ? 8.17520   -4.47598 15.83486  1.000 66.45973  ? 269 LYS A NZ   1 
ATOM   4089 H H    . LYS A 1 269 ? 6.18622   1.58485  19.29445  1.000 25.24630  ? 269 LYS A H    1 
ATOM   4090 H HA   . LYS A 1 269 ? 4.80889   0.20943  17.60047  1.000 32.67700  ? 269 LYS A HA   1 
ATOM   4091 H HB2  . LYS A 1 269 ? 7.10372   0.09209  17.55196  1.000 29.88087  ? 269 LYS A HB2  1 
ATOM   4092 H HB3  . LYS A 1 269 ? 7.13525   -0.57677 18.99316  1.000 29.88087  ? 269 LYS A HB3  1 
ATOM   4093 H HG2  . LYS A 1 269 ? 6.24002   -2.52608 18.12005  1.000 39.46078  ? 269 LYS A HG2  1 
ATOM   4094 H HG3  . LYS A 1 269 ? 6.16951   -1.85793 16.67991  1.000 39.46078  ? 269 LYS A HG3  1 
ATOM   4095 H HD2  . LYS A 1 269 ? 8.36709   -2.01385 16.36754  1.000 50.42189  ? 269 LYS A HD2  1 
ATOM   4096 H HD3  . LYS A 1 269 ? 8.67772   -2.01360 17.92604  1.000 50.42189  ? 269 LYS A HD3  1 
ATOM   4097 H HE2  . LYS A 1 269 ? 9.06407   -4.14145 17.60963  1.000 71.04180  ? 269 LYS A HE2  1 
ATOM   4098 H HE3  . LYS A 1 269 ? 7.48394   -4.27404 17.71454  1.000 71.04180  ? 269 LYS A HE3  1 
ATOM   4099 H HZ1  . LYS A 1 269 ? 8.88235   -4.20547 15.36704  1.000 79.75167  ? 269 LYS A HZ1  1 
ATOM   4100 H HZ2  . LYS A 1 269 ? 8.18284   -5.36470 15.88202  1.000 79.75167  ? 269 LYS A HZ2  1 
ATOM   4101 H HZ3  . LYS A 1 269 ? 7.43464   -4.21534 15.41564  1.000 79.75167  ? 269 LYS A HZ3  1 
ATOM   4102 N N    . GLU A 1 270 ? 4.66426   -1.07563 20.54387  1.000 23.21053  ? 270 GLU A N    1 
ATOM   4103 C CA   . GLU A 1 270 ? 3.89754   -2.02392 21.33771  1.000 21.68577  ? 270 GLU A CA   1 
ATOM   4104 C C    . GLU A 1 270 ? 2.44108   -1.60483 21.44229  1.000 24.63993  ? 270 GLU A C    1 
ATOM   4105 O O    . GLU A 1 270 ? 1.54111   -2.44874 21.40572  1.000 27.37329  ? 270 GLU A O    1 
ATOM   4106 C CB   . GLU A 1 270 ? 4.52026   -2.16966 22.73930  1.000 27.63368  ? 270 GLU A CB   1 
ATOM   4107 C CG   . GLU A 1 270 ? 5.88163   -2.81655 22.73035  1.000 39.17702  ? 270 GLU A CG   1 
ATOM   4108 C CD   . GLU A 1 270 ? 5.88852   -4.15615 22.01126  1.000 59.07588  ? 270 GLU A CD   1 
ATOM   4109 O OE1  . GLU A 1 270 ? 5.06666   -5.02895 22.37109  1.000 59.08494  ? 270 GLU A OE1  1 
ATOM   4110 O OE2  . GLU A 1 270 ? 6.70211   -4.31805 21.07602  1.000 52.81289  ? 270 GLU A OE2  1 
ATOM   4111 H H    . GLU A 1 270 ? 5.26319   -0.63675 20.97777  1.000 27.85264  ? 270 GLU A H    1 
ATOM   4112 H HA   . GLU A 1 270 ? 3.93094   -2.89074 20.90366  1.000 26.02292  ? 270 GLU A HA   1 
ATOM   4113 H HB2  . GLU A 1 270 ? 4.61311   -1.28808 23.13312  1.000 33.16041  ? 270 GLU A HB2  1 
ATOM   4114 H HB3  . GLU A 1 270 ? 3.93504   -2.71717 23.28579  1.000 33.16041  ? 270 GLU A HB3  1 
ATOM   4115 H HG2  . GLU A 1 270 ? 6.50794   -2.22975 22.27836  1.000 47.01242  ? 270 GLU A HG2  1 
ATOM   4116 H HG3  . GLU A 1 270 ? 6.16743   -2.96526 23.64529  1.000 47.01242  ? 270 GLU A HG3  1 
ATOM   4117 N N    . LEU A 1 271 ? 2.18132   -0.29443 21.58553  1.000 23.44760  ? 271 LEU A N    1 
ATOM   4118 C CA   . LEU A 1 271 ? 0.78920   0.15940  21.65872  1.000 23.16271  ? 271 LEU A CA   1 
ATOM   4119 C C    . LEU A 1 271 ? 0.04981   -0.11593 20.36240  1.000 21.30406  ? 271 LEU A C    1 
ATOM   4120 O O    . LEU A 1 271 ? -1.13702  -0.45083 20.37479  1.000 25.46098  ? 271 LEU A O    1 
ATOM   4121 C CB   . LEU A 1 271 ? 0.75173   1.65923  22.00300  1.000 25.19549  ? 271 LEU A CB   1 
ATOM   4122 C CG   . LEU A 1 271 ? 1.13363   2.01749  23.44785  1.000 22.23820  ? 271 LEU A CG   1 
ATOM   4123 C CD1  . LEU A 1 271 ? 1.35599   3.52825  23.58238  1.000 22.27238  ? 271 LEU A CD1  1 
ATOM   4124 C CD2  . LEU A 1 271 ? 0.08336   1.55158  24.44017  1.000 23.54305  ? 271 LEU A CD2  1 
ATOM   4125 H H    . LEU A 1 271 ? 2.77309   0.32717  21.64054  1.000 28.13712  ? 271 LEU A H    1 
ATOM   4126 H HA   . LEU A 1 271 ? 0.33377   -0.32496 22.36503  1.000 27.79526  ? 271 LEU A HA   1 
ATOM   4127 H HB2  . LEU A 1 271 ? 1.37146   2.12134  21.41709  1.000 30.23459  ? 271 LEU A HB2  1 
ATOM   4128 H HB3  . LEU A 1 271 ? -0.15031  1.98313  21.85359  1.000 30.23459  ? 271 LEU A HB3  1 
ATOM   4129 H HG   . LEU A 1 271 ? 1.96032   1.55829  23.66375  1.000 26.68585  ? 271 LEU A HG   1 
ATOM   4130 H HD11 . LEU A 1 271 ? 1.55589   3.73681  24.50836  1.000 26.72685  ? 271 LEU A HD11 1 
ATOM   4131 H HD12 . LEU A 1 271 ? 2.09922   3.78968  23.01654  1.000 26.72685  ? 271 LEU A HD12 1 
ATOM   4132 H HD13 . LEU A 1 271 ? 0.55029   3.99195  23.30537  1.000 26.72685  ? 271 LEU A HD13 1 
ATOM   4133 H HD21 . LEU A 1 271 ? -0.06942  0.60181  24.31567  1.000 28.25166  ? 271 LEU A HD21 1 
ATOM   4134 H HD22 . LEU A 1 271 ? 0.40277   1.72001  25.34045  1.000 28.25166  ? 271 LEU A HD22 1 
ATOM   4135 H HD23 . LEU A 1 271 ? -0.73866  2.04216  24.28363  1.000 28.25166  ? 271 LEU A HD23 1 
ATOM   4136 N N    . LEU A 1 272 ? 0.73808   0.01809  19.23672  1.000 22.55671  ? 272 LEU A N    1 
ATOM   4137 C CA   . LEU A 1 272 ? 0.09511   -0.22391 17.95001  1.000 21.69879  ? 272 LEU A CA   1 
ATOM   4138 C C    . LEU A 1 272 ? -0.21284  -1.70513 17.78114  1.000 25.65417  ? 272 LEU A C    1 
ATOM   4139 O O    . LEU A 1 272 ? -1.29180  -2.06868 17.30338  1.000 27.48822  ? 272 LEU A O    1 
ATOM   4140 C CB   . LEU A 1 272 ? 0.97703   0.27748  16.82412  1.000 23.97752  ? 272 LEU A CB   1 
ATOM   4141 C CG   . LEU A 1 272 ? 0.99971   1.81785  16.69649  1.000 23.45807  ? 272 LEU A CG   1 
ATOM   4142 C CD1  . LEU A 1 272 ? 2.01085   2.25889  15.66280  1.000 26.61655  ? 272 LEU A CD1  1 
ATOM   4143 C CD2  . LEU A 1 272 ? -0.38715  2.33551  16.36987  1.000 27.81801  ? 272 LEU A CD2  1 
ATOM   4144 H H    . LEU A 1 272 ? 1.56630   0.24461  19.18843  1.000 27.06805  ? 272 LEU A H    1 
ATOM   4145 H HA   . LEU A 1 272 ? -0.73910  0.26926  17.90778  1.000 26.03855  ? 272 LEU A HA   1 
ATOM   4146 H HB2  . LEU A 1 272 ? 1.88603   -0.02144 16.98310  1.000 28.77303  ? 272 LEU A HB2  1 
ATOM   4147 H HB3  . LEU A 1 272 ? 0.65007   -0.08584 15.98627  1.000 28.77303  ? 272 LEU A HB3  1 
ATOM   4148 H HG   . LEU A 1 272 ? 1.27048   2.20549  17.54343  1.000 28.14969  ? 272 LEU A HG   1 
ATOM   4149 H HD11 . LEU A 1 272 ? 1.96954   3.22377  15.57223  1.000 31.93986  ? 272 LEU A HD11 1 
ATOM   4150 H HD12 . LEU A 1 272 ? 2.89681   1.99158  15.95352  1.000 31.93986  ? 272 LEU A HD12 1 
ATOM   4151 H HD13 . LEU A 1 272 ? 1.79986   1.83773  14.81486  1.000 31.93986  ? 272 LEU A HD13 1 
ATOM   4152 H HD21 . LEU A 1 272 ? -0.31562  3.24631  16.04397  1.000 33.38162  ? 272 LEU A HD21 1 
ATOM   4153 H HD22 . LEU A 1 272 ? -0.78271  1.77031  15.68798  1.000 33.38162  ? 272 LEU A HD22 1 
ATOM   4154 H HD23 . LEU A 1 272 ? -0.92985  2.31342  17.17353  1.000 33.38162  ? 272 LEU A HD23 1 
ATOM   4155 N N    . GLN A 1 273 ? 0.69715   -2.55914 18.23887  1.000 30.57388  ? 273 GLN A N    1 
ATOM   4156 C CA   . GLN A 1 273 ? 0.56617   -4.00361 18.01253  1.000 35.22931  ? 273 GLN A CA   1 
ATOM   4157 C C    . GLN A 1 273 ? -0.36379  -4.66962 19.01479  1.000 32.75705  ? 273 GLN A C    1 
ATOM   4158 O O    . GLN A 1 273 ? -0.97635  -5.68884 18.69209  1.000 42.41842  ? 273 GLN A O    1 
ATOM   4159 C CB   . GLN A 1 273 ? 1.94738   -4.64445 18.06815  1.000 26.28615  ? 273 GLN A CB   1 
ATOM   4160 C CG   . GLN A 1 273 ? 2.79496   -4.32604 16.87328  1.000 26.43463  ? 273 GLN A CG   1 
ATOM   4161 C CD   . GLN A 1 273 ? 4.21233   -4.85482 16.97895  1.000 39.72634  ? 273 GLN A CD   1 
ATOM   4162 O OE1  . GLN A 1 273 ? 4.64307   -5.32620 18.03528  1.000 45.17561  ? 273 GLN A OE1  1 
ATOM   4163 N NE2  . GLN A 1 273 ? 4.94942   -4.76023 15.88762  1.000 40.75884  ? 273 GLN A NE2  1 
ATOM   4164 H H    . GLN A 1 273 ? 1.39881   -2.33403 18.68227  1.000 36.68865  ? 273 GLN A H    1 
ATOM   4165 H HA   . GLN A 1 273 ? 0.18919   -4.15334 17.13142  1.000 42.27518  ? 273 GLN A HA   1 
ATOM   4166 H HB2  . GLN A 1 273 ? 2.41104   -4.32299 18.85718  1.000 31.54338  ? 273 GLN A HB2  1 
ATOM   4167 H HB3  . GLN A 1 273 ? 1.84481   -5.60796 18.11311  1.000 31.54338  ? 273 GLN A HB3  1 
ATOM   4168 H HG2  . GLN A 1 273 ? 2.38846   -4.72180 16.08649  1.000 31.72155  ? 273 GLN A HG2  1 
ATOM   4169 H HG3  . GLN A 1 273 ? 2.84442   -3.36260 16.77212  1.000 31.72155  ? 273 GLN A HG3  1 
ATOM   4170 H HE21 . GLN A 1 273 ? 4.61791   -4.41427 15.17347  1.000 48.91061  ? 273 GLN A HE21 1 
ATOM   4171 H HE22 . GLN A 1 273 ? 5.76105   -5.04458 15.89092  1.000 48.91061  ? 273 GLN A HE22 1 
ATOM   4172 N N    . ASN A 1 274 ? -0.51195  -4.10118 20.21313  1.000 32.46718  ? 274 ASN A N    1 
ATOM   4173 C CA   . ASN A 1 274 ? -1.26633  -4.73900 21.27184  1.000 33.14429  ? 274 ASN A CA   1 
ATOM   4174 C C    . ASN A 1 274 ? -2.42665  -3.91490 21.79654  1.000 37.69545  ? 274 ASN A C    1 
ATOM   4175 O O    . ASN A 1 274 ? -3.24636  -4.44733 22.55167  1.000 37.44468  ? 274 ASN A O    1 
ATOM   4176 C CB   . ASN A 1 274 ? -0.32622  -5.08575 22.43969  1.000 41.82117  ? 274 ASN A CB   1 
ATOM   4177 C CG   . ASN A 1 274 ? 0.73930   -6.09311 22.03830  1.000 44.33886  ? 274 ASN A CG   1 
ATOM   4178 O OD1  . ASN A 1 274 ? 1.88131   -5.73287 21.76383  1.000 55.78127  ? 274 ASN A OD1  1 
ATOM   4179 N ND2  . ASN A 1 274 ? 0.36222   -7.36371 21.99225  1.000 64.65123  ? 274 ASN A ND2  1 
ATOM   4180 H H    . ASN A 1 274 ? -0.17867  -3.33899 20.43128  1.000 38.96062  ? 274 ASN A H    1 
ATOM   4181 H HA   . ASN A 1 274 ? -1.64339  -5.56418 20.92862  1.000 39.77315  ? 274 ASN A HA   1 
ATOM   4182 H HB2  . ASN A 1 274 ? 0.11902   -4.27821 22.74059  1.000 50.18540  ? 274 ASN A HB2  1 
ATOM   4183 H HB3  . ASN A 1 274 ? -0.84594  -5.46766 23.16421  1.000 50.18540  ? 274 ASN A HB3  1 
ATOM   4184 H HD21 . ASN A 1 274 ? 0.92792   -7.97236 21.77061  1.000 77.58148  ? 274 ASN A HD21 1 
ATOM   4185 H HD22 . ASN A 1 274 ? -0.44800  -7.57901 22.18402  1.000 77.58148  ? 274 ASN A HD22 1 
ATOM   4186 N N    . GLY A 1 275 ? -2.54908  -2.65010 21.39733  1.000 34.80611  ? 275 GLY A N    1 
ATOM   4187 C CA   . GLY A 1 275 ? -3.58423  -1.83663 21.99039  1.000 31.76196  ? 275 GLY A CA   1 
ATOM   4188 C C    . GLY A 1 275 ? -3.22358  -1.47019 23.42916  1.000 27.40797  ? 275 GLY A C    1 
ATOM   4189 O O    . GLY A 1 275 ? -2.08432  -1.59912 23.86971  1.000 33.97161  ? 275 GLY A O    1 
ATOM   4190 H H    . GLY A 1 275 ? -2.06018  -2.26080 20.80655  1.000 41.76734  ? 275 GLY A H    1 
ATOM   4191 H HA2  . GLY A 1 275 ? -3.69399  -1.02053 21.47771  1.000 38.11435  ? 275 GLY A HA2  1 
ATOM   4192 H HA3  . GLY A 1 275 ? -4.42314  -2.32358 21.99236  1.000 38.11435  ? 275 GLY A HA3  1 
ATOM   4193 N N    . MET A 1 276 ? -4.23451  -1.01837 24.16488  1.000 29.80706  ? 276 MET A N    1 
ATOM   4194 C CA   . MET A 1 276 ? -4.05613  -0.49666 25.50224  1.000 38.73429  ? 276 MET A CA   1 
ATOM   4195 C C    . MET A 1 276 ? -4.50974  -1.45005 26.59939  1.000 42.49208  ? 276 MET A C    1 
ATOM   4196 O O    . MET A 1 276 ? -4.18105  -1.20929 27.76375  1.000 35.78966  ? 276 MET A O    1 
ATOM   4197 C CB   . MET A 1 276 ? -4.80179  0.82791  25.66255  1.000 32.52890  ? 276 MET A CB   1 
ATOM   4198 C CG   . MET A 1 276 ? -4.29689  1.91567  24.72014  1.000 36.53020  ? 276 MET A CG   1 
ATOM   4199 S SD   . MET A 1 276 ? -4.61068  3.55201  25.37381  1.000 35.56354  ? 276 MET A SD   1 
ATOM   4200 C CE   . MET A 1 276 ? -4.06766  4.53269  23.95896  1.000 35.41744  ? 276 MET A CE   1 
ATOM   4201 H H    . MET A 1 276 ? -5.05227  -1.00585 23.89896  1.000 35.76847  ? 276 MET A H    1 
ATOM   4202 H HA   . MET A 1 276 ? -3.10936  -0.32333 25.62255  1.000 46.48115  ? 276 MET A HA   1 
ATOM   4203 H HB2  . MET A 1 276 ? -5.74270  0.68368  25.47603  1.000 39.03468  ? 276 MET A HB2  1 
ATOM   4204 H HB3  . MET A 1 276 ? -4.68865  1.14435  26.57247  1.000 39.03468  ? 276 MET A HB3  1 
ATOM   4205 H HG2  . MET A 1 276 ? -3.33996  1.81471  24.59766  1.000 43.83624  ? 276 MET A HG2  1 
ATOM   4206 H HG3  . MET A 1 276 ? -4.75081  1.83620  23.86660  1.000 43.83624  ? 276 MET A HG3  1 
ATOM   4207 H HE1  . MET A 1 276 ? -3.64022  5.34173  24.28088  1.000 42.50092  ? 276 MET A HE1  1 
ATOM   4208 H HE2  . MET A 1 276 ? -3.43825  4.01150  23.43637  1.000 42.50092  ? 276 MET A HE2  1 
ATOM   4209 H HE3  . MET A 1 276 ? -4.83953  4.75953  23.41705  1.000 42.50092  ? 276 MET A HE3  1 
ATOM   4210 N N    . ASN A 1 277 ? -5.23229  -2.51706 26.26354  1.000 42.76792  ? 277 ASN A N    1 
ATOM   4211 C CA   . ASN A 1 277 ? -5.72768  -3.47253 27.26131  1.000 45.85947  ? 277 ASN A CA   1 
ATOM   4212 C C    . ASN A 1 277 ? -6.56299  -2.77391 28.33472  1.000 44.21327  ? 277 ASN A C    1 
ATOM   4213 O O    . ASN A 1 277 ? -6.34155  -2.94237 29.54180  1.000 41.35147  ? 277 ASN A O    1 
ATOM   4214 C CB   . ASN A 1 277 ? -4.58581  -4.27728 27.88301  1.000 53.96104  ? 277 ASN A CB   1 
ATOM   4215 C CG   . ASN A 1 277 ? -4.09015  -5.37444 26.96593  1.000 68.25189  ? 277 ASN A CG   1 
ATOM   4216 O OD1  . ASN A 1 277 ? -4.69147  -6.44708 26.88615  1.000 84.82499  ? 277 ASN A OD1  1 
ATOM   4217 N ND2  . ASN A 1 277 ? -2.98866  -5.11219 26.26364  1.000 52.91968  ? 277 ASN A ND2  1 
ATOM   4218 H H    . ASN A 1 277 ? -5.45279  -2.71412 25.45598  1.000 51.32150  ? 277 ASN A H    1 
ATOM   4219 H HA   . ASN A 1 277 ? -6.31151  -4.10011 26.80723  1.000 55.03137  ? 277 ASN A HA   1 
ATOM   4220 H HB2  . ASN A 1 277 ? -3.84308  -3.68226 28.07063  1.000 64.75324  ? 277 ASN A HB2  1 
ATOM   4221 H HB3  . ASN A 1 277 ? -4.89728  -4.68836 28.70453  1.000 64.75324  ? 277 ASN A HB3  1 
ATOM   4222 H HD21 . ASN A 1 277 ? -2.66850  -5.70464 25.72876  1.000 63.50361  ? 277 ASN A HD21 1 
ATOM   4223 H HD22 . ASN A 1 277 ? -2.59787  -4.35046 26.34521  1.000 63.50361  ? 277 ASN A HD22 1 
ATOM   4224 N N    . GLY A 1 278 ? -7.53281  -1.98101 27.88007  1.000 41.40804  ? 278 GLY A N    1 
ATOM   4225 C CA   . GLY A 1 278 ? -8.47268  -1.32927 28.76253  1.000 35.98975  ? 278 GLY A CA   1 
ATOM   4226 C C    . GLY A 1 278 ? -7.93692  -0.15129 29.54110  1.000 36.19060  ? 278 GLY A C    1 
ATOM   4227 O O    . GLY A 1 278 ? -8.67420  0.42363  30.34856  1.000 45.33167  ? 278 GLY A O    1 
ATOM   4228 H H    . GLY A 1 278 ? -7.66253  -1.80694 27.04792  1.000 49.68965  ? 278 GLY A H    1 
ATOM   4229 H HA2  . GLY A 1 278 ? -9.22137  -1.01276 28.23321  1.000 43.18770  ? 278 GLY A HA2  1 
ATOM   4230 H HA3  . GLY A 1 278 ? -8.79336  -1.98171 29.40470  1.000 43.18770  ? 278 GLY A HA3  1 
ATOM   4231 N N    . ARG A 1 279 ? -6.68141  0.23270  29.32692  1.000 36.04742  ? 279 ARG A N    1 
ATOM   4232 C CA   . ARG A 1 279 ? -6.10490  1.36801  30.02645  1.000 33.63817  ? 279 ARG A CA   1 
ATOM   4233 C C    . ARG A 1 279 ? -6.23406  2.63198  29.17452  1.000 24.99320  ? 279 ARG A C    1 
ATOM   4234 O O    . ARG A 1 279 ? -6.66200  2.59910  28.01600  1.000 29.01073  ? 279 ARG A O    1 
ATOM   4235 C CB   . ARG A 1 279 ? -4.64107  1.08228  30.35496  1.000 31.56183  ? 279 ARG A CB   1 
ATOM   4236 C CG   . ARG A 1 279 ? -4.48880  0.01669  31.46067  1.000 36.73486  ? 279 ARG A CG   1 
ATOM   4237 C CD   . ARG A 1 279 ? -3.05911  -0.46579 31.57612  1.000 35.42280  ? 279 ARG A CD   1 
ATOM   4238 N NE   . ARG A 1 279 ? -2.65327  -1.21384 30.39081  1.000 41.89886  ? 279 ARG A NE   1 
ATOM   4239 C CZ   . ARG A 1 279 ? -1.48752  -1.83478 30.26035  1.000 39.59629  ? 279 ARG A CZ   1 
ATOM   4240 N NH1  . ARG A 1 279 ? -0.59435  -1.84813 31.24340  1.000 39.05110  ? 279 ARG A NH1  1 
ATOM   4241 N NH2  . ARG A 1 279 ? -1.20543  -2.45230 29.11482  1.000 36.74529  ? 279 ARG A NH2  1 
ATOM   4242 H H    . ARG A 1 279 ? -6.14325  -0.15246 28.77771  1.000 43.25691  ? 279 ARG A H    1 
ATOM   4243 H HA   . ARG A 1 279 ? -6.57869  1.51847  30.85938  1.000 40.36580  ? 279 ARG A HA   1 
ATOM   4244 H HB2  . ARG A 1 279 ? -4.19404  0.75735  29.55778  1.000 37.87420  ? 279 ARG A HB2  1 
ATOM   4245 H HB3  . ARG A 1 279 ? -4.21890  1.89977  30.66217  1.000 37.87420  ? 279 ARG A HB3  1 
ATOM   4246 H HG2  . ARG A 1 279 ? -4.75095  0.39873  32.31286  1.000 44.08183  ? 279 ARG A HG2  1 
ATOM   4247 H HG3  . ARG A 1 279 ? -5.05136  -0.74537 31.25164  1.000 44.08183  ? 279 ARG A HG3  1 
ATOM   4248 H HD2  . ARG A 1 279 ? -2.46877  0.29781  31.67263  1.000 42.50736  ? 279 ARG A HD2  1 
ATOM   4249 H HD3  . ARG A 1 279 ? -2.97742  -1.04790 32.34773  1.000 42.50736  ? 279 ARG A HD3  1 
ATOM   4250 H HE   . ARG A 1 279 ? -3.20601  -1.25509 29.73325  1.000 50.27863  ? 279 ARG A HE   1 
ATOM   4251 H HH11 . ARG A 1 279 ? -0.76551  -1.44835 31.98535  1.000 46.86132  ? 279 ARG A HH11 1 
ATOM   4252 H HH12 . ARG A 1 279 ? 0.15510   -2.25654 31.13794  1.000 46.86132  ? 279 ARG A HH12 1 
ATOM   4253 H HH21 . ARG A 1 279 ? -1.77549  -2.44549 28.47093  1.000 44.09434  ? 279 ARG A HH21 1 
ATOM   4254 H HH22 . ARG A 1 279 ? -0.45319  -2.85792 29.01887  1.000 44.09434  ? 279 ARG A HH22 1 
ATOM   4255 N N    . THR A 1 280 ? -5.85790  3.74498  29.77333  1.000 27.81789  ? 280 THR A N    1 
ATOM   4256 C CA   . THR A 1 280 ? -5.95586  5.04826  29.11812  1.000 26.59167  ? 280 THR A CA   1 
ATOM   4257 C C    . THR A 1 280 ? -4.66415  5.81879  29.30876  1.000 21.25805  ? 280 THR A C    1 
ATOM   4258 O O    . THR A 1 280 ? -3.84900  5.55098  30.20808  1.000 21.92295  ? 280 THR A O    1 
ATOM   4259 C CB   . THR A 1 280 ? -7.13248  5.86620  29.67248  1.000 25.15551  ? 280 THR A CB   1 
ATOM   4260 O OG1  . THR A 1 280 ? -6.96886  6.07046  31.08139  1.000 28.26661  ? 280 THR A OG1  1 
ATOM   4261 C CG2  . THR A 1 280 ? -8.44385  5.10166  29.41731  1.000 28.57792  ? 280 THR A CG2  1 
ATOM   4262 H H    . THR A 1 280 ? -5.53721  3.77877  30.57058  1.000 33.38146  ? 280 THR A H    1 
ATOM   4263 H HA   . THR A 1 280 ? -6.09064  4.91660  28.16659  1.000 31.91000  ? 280 THR A HA   1 
ATOM   4264 H HB   . THR A 1 280 ? -7.17163  6.73127  29.23542  1.000 30.18661  ? 280 THR A HB   1 
ATOM   4265 H HG1  . THR A 1 280 ? -7.51994  6.64248  31.35467  1.000 33.91993  ? 280 THR A HG1  1 
ATOM   4266 H HG21 . THR A 1 280 ? -8.58531  4.44333  30.11551  1.000 34.29350  ? 280 THR A HG21 1 
ATOM   4267 H HG22 . THR A 1 280 ? -9.19193  5.71910  29.41058  1.000 34.29350  ? 280 THR A HG22 1 
ATOM   4268 H HG23 . THR A 1 280 ? -8.40224  4.64820  28.56084  1.000 34.29350  ? 280 THR A HG23 1 
ATOM   4269 N N    . ILE A 1 281 ? -4.46861  6.80872  28.43481  1.000 17.87141  ? 281 ILE A N    1 
ATOM   4270 C CA   . ILE A 1 281 ? -3.35219  7.72234  28.47071  1.000 18.02464  ? 281 ILE A CA   1 
ATOM   4271 C C    . ILE A 1 281 ? -3.94402  9.13214  28.38153  1.000 19.22790  ? 281 ILE A C    1 
ATOM   4272 O O    . ILE A 1 281 ? -4.63148  9.45594  27.40180  1.000 20.26148  ? 281 ILE A O    1 
ATOM   4273 C CB   . ILE A 1 281 ? -2.39018  7.48590  27.28796  1.000 19.42100  ? 281 ILE A CB   1 
ATOM   4274 C CG1  . ILE A 1 281 ? -1.84623  6.05129  27.30663  1.000 19.89570  ? 281 ILE A CG1  1 
ATOM   4275 C CG2  . ILE A 1 281 ? -1.27677  8.50389  27.30303  1.000 19.21709  ? 281 ILE A CG2  1 
ATOM   4276 C CD1  . ILE A 1 281 ? -1.02019  5.66886  26.09072  1.000 20.60313  ? 281 ILE A CD1  1 
ATOM   4277 H H    . ILE A 1 281 ? -5.00398  6.97035  27.78147  1.000 21.44570  ? 281 ILE A H    1 
ATOM   4278 H HA   . ILE A 1 281 ? -2.85926  7.62266  29.30016  1.000 21.62957  ? 281 ILE A HA   1 
ATOM   4279 H HB   . ILE A 1 281 ? -2.88528  7.59781  26.46137  1.000 23.30520  ? 281 ILE A HB   1 
ATOM   4280 H HG12 . ILE A 1 281 ? -1.28126  5.94617  28.08808  1.000 23.87484  ? 281 ILE A HG12 1 
ATOM   4281 H HG13 . ILE A 1 281 ? -2.59624  5.43804  27.35456  1.000 23.87484  ? 281 ILE A HG13 1 
ATOM   4282 H HG21 . ILE A 1 281 ? -0.62059  8.26420  26.63007  1.000 23.06051  ? 281 ILE A HG21 1 
ATOM   4283 H HG22 . ILE A 1 281 ? -1.64645  9.37914  27.10762  1.000 23.06051  ? 281 ILE A HG22 1 
ATOM   4284 H HG23 . ILE A 1 281 ? -0.86411  8.50759  28.18087  1.000 23.06051  ? 281 ILE A HG23 1 
ATOM   4285 H HD11 . ILE A 1 281 ? -0.95447  4.70217  26.04492  1.000 24.72375  ? 281 ILE A HD11 1 
ATOM   4286 H HD12 . ILE A 1 281 ? -1.45562  6.00893  25.29345  1.000 24.72375  ? 281 ILE A HD12 1 
ATOM   4287 H HD13 . ILE A 1 281 ? -0.13524  6.05692  26.17537  1.000 24.72375  ? 281 ILE A HD13 1 
ATOM   4288 N N    . LEU A 1 282 ? -3.67403  9.96284  29.38701  1.000 21.40246  ? 282 LEU A N    1 
ATOM   4289 C CA   . LEU A 1 282 ? -4.18145  11.33745 29.41707  1.000 20.06091  ? 282 LEU A CA   1 
ATOM   4290 C C    . LEU A 1 282 ? -5.67677  11.39523 29.11612  1.000 24.64886  ? 282 LEU A C    1 
ATOM   4291 O O    . LEU A 1 282 ? -6.14918  12.25625 28.37714  1.000 23.53440  ? 282 LEU A O    1 
ATOM   4292 C CB   . LEU A 1 282 ? -3.39443  12.26488 28.49356  1.000 19.97153  ? 282 LEU A CB   1 
ATOM   4293 C CG   . LEU A 1 282 ? -1.98061  12.56025 28.99212  1.000 16.60830  ? 282 LEU A CG   1 
ATOM   4294 C CD1  . LEU A 1 282 ? -1.16319  13.29099 27.93306  1.000 21.17745  ? 282 LEU A CD1  1 
ATOM   4295 C CD2  . LEU A 1 282 ? -1.99228  13.38100 30.30263  1.000 22.15430  ? 282 LEU A CD2  1 
ATOM   4296 H H    . LEU A 1 282 ? -3.19525  9.75400  30.07020  1.000 25.68295  ? 282 LEU A H    1 
ATOM   4297 H HA   . LEU A 1 282 ? -4.05780  11.66630 30.32122  1.000 24.07310  ? 282 LEU A HA   1 
ATOM   4298 H HB2  . LEU A 1 282 ? -3.32202  11.84870 27.62037  1.000 23.96584  ? 282 LEU A HB2  1 
ATOM   4299 H HB3  . LEU A 1 282 ? -3.86747  13.10858 28.42075  1.000 23.96584  ? 282 LEU A HB3  1 
ATOM   4300 H HG   . LEU A 1 282 ? -1.55594  11.70800 29.17712  1.000 19.92996  ? 282 LEU A HG   1 
ATOM   4301 H HD11 . LEU A 1 282 ? -0.28533  13.49092 28.29402  1.000 25.41294  ? 282 LEU A HD11 1 
ATOM   4302 H HD12 . LEU A 1 282 ? -1.07797  12.72229 27.15189  1.000 25.41294  ? 282 LEU A HD12 1 
ATOM   4303 H HD13 . LEU A 1 282 ? -1.61825  14.11390 27.69508  1.000 25.41294  ? 282 LEU A HD13 1 
ATOM   4304 H HD21 . LEU A 1 282 ? -1.10156  13.72895 30.46528  1.000 26.58516  ? 282 LEU A HD21 1 
ATOM   4305 H HD22 . LEU A 1 282 ? -2.62182  14.11325 30.21106  1.000 26.58516  ? 282 LEU A HD22 1 
ATOM   4306 H HD23 . LEU A 1 282 ? -2.26060  12.80365 31.03445  1.000 26.58516  ? 282 LEU A HD23 1 
ATOM   4307 N N    . GLY A 1 283 ? -6.41928  10.46434 29.70128  1.000 24.17770  ? 283 GLY A N    1 
ATOM   4308 C CA   . GLY A 1 283 ? -7.85849  10.44908 29.55992  1.000 28.03479  ? 283 GLY A CA   1 
ATOM   4309 C C    . GLY A 1 283 ? -8.39654  9.94742  28.23548  1.000 24.79831  ? 283 GLY A C    1 
ATOM   4310 O O    . GLY A 1 283 ? -9.58594  10.13112 27.95578  1.000 30.44900  ? 283 GLY A O    1 
ATOM   4311 H H    . GLY A 1 283 ? -6.10671  9.82798  30.18806  1.000 29.01323  ? 283 GLY A H    1 
ATOM   4312 H HA2  . GLY A 1 283 ? -8.22732  9.88277  30.25574  1.000 33.64174  ? 283 GLY A HA2  1 
ATOM   4313 H HA3  . GLY A 1 283 ? -8.18656  11.35371 29.68204  1.000 33.64174  ? 283 GLY A HA3  1 
ATOM   4314 N N    . SER A 1 284 ? -7.56040  9.35282  27.38604  1.000 22.37541  ? 284 SER A N    1 
ATOM   4315 C CA   . SER A 1 284 ? -7.96767  8.84422  26.09219  1.000 20.82287  ? 284 SER A CA   1 
ATOM   4316 C C    . SER A 1 284 ? -7.68889  7.35120  25.98643  1.000 21.56589  ? 284 SER A C    1 
ATOM   4317 O O    . SER A 1 284 ? -6.66899  6.85741  26.48537  1.000 23.99245  ? 284 SER A O    1 
ATOM   4318 C CB   . SER A 1 284 ? -7.22172  9.59713  24.98924  1.000 22.89569  ? 284 SER A CB   1 
ATOM   4319 O OG   . SER A 1 284 ? -7.59063  9.10763  23.70398  1.000 26.99836  ? 284 SER A OG   1 
ATOM   4320 H H    . SER A 1 284 ? -6.72472  9.23151  27.54889  1.000 26.85049  ? 284 SER A H    1 
ATOM   4321 H HA   . SER A 1 284 ? -8.92379  8.96035  25.97705  1.000 24.98745  ? 284 SER A HA   1 
ATOM   4322 H HB2  . SER A 1 284 ? -7.44419  10.53968 25.04410  1.000 27.47483  ? 284 SER A HB2  1 
ATOM   4323 H HB3  . SER A 1 284 ? -6.26750  9.47377  25.11231  1.000 27.47483  ? 284 SER A HB3  1 
ATOM   4324 H HG   . SER A 1 284 ? -8.42494  9.02150  23.65797  1.000 32.39803  ? 284 SER A HG   1 
ATOM   4325 N N    . ALA A 1 285 ? -8.58778  6.63858  25.32841  1.000 22.84482  ? 285 ALA A N    1 
ATOM   4326 C CA   . ALA A 1 285 ? -8.34073  5.25027  24.95495  1.000 21.64637  ? 285 ALA A CA   1 
ATOM   4327 C C    . ALA A 1 285 ? -7.84243  5.10770  23.52688  1.000 23.38107  ? 285 ALA A C    1 
ATOM   4328 O O    . ALA A 1 285 ? -7.79101  3.98259  23.02375  1.000 25.54066  ? 285 ALA A O    1 
ATOM   4329 C CB   . ALA A 1 285 ? -9.61632  4.41798  25.14454  1.000 27.15774  ? 285 ALA A CB   1 
ATOM   4330 H H    . ALA A 1 285 ? -9.35627  6.93691  25.08341  1.000 27.41379  ? 285 ALA A H    1 
ATOM   4331 H HA   . ALA A 1 285 ? -7.65815  4.89307  25.54434  1.000 25.97565  ? 285 ALA A HA   1 
ATOM   4332 H HB1  . ALA A 1 285 ? -9.45996  3.52024  24.81210  1.000 32.58928  ? 285 ALA A HB1  1 
ATOM   4333 H HB2  . ALA A 1 285 ? -9.83603  4.38744  26.08883  1.000 32.58928  ? 285 ALA A HB2  1 
ATOM   4334 H HB3  . ALA A 1 285 ? -10.34033 4.83253  24.64970  1.000 32.58928  ? 285 ALA A HB3  1 
ATOM   4335 N N    . LEU A 1 286 ? -7.48868  6.21240  22.86348  1.000 20.51028  ? 286 LEU A N    1 
ATOM   4336 C CA   . LEU A 1 286 ? -6.89166  6.19224  21.53594  1.000 21.27054  ? 286 LEU A CA   1 
ATOM   4337 C C    . LEU A 1 286 ? -5.59718  7.00615  21.56452  1.000 18.21991  ? 286 LEU A C    1 
ATOM   4338 O O    . LEU A 1 286 ? -5.40029  7.86704  22.42755  1.000 22.14281  ? 286 LEU A O    1 
ATOM   4339 C CB   . LEU A 1 286 ? -7.80650  6.85714  20.49979  1.000 25.24944  ? 286 LEU A CB   1 
ATOM   4340 C CG   . LEU A 1 286 ? -9.18147  6.27946  20.30147  1.000 39.15957  ? 286 LEU A CG   1 
ATOM   4341 C CD1  . LEU A 1 286 ? -9.94496  7.12619  19.29331  1.000 33.19359  ? 286 LEU A CD1  1 
ATOM   4342 C CD2  . LEU A 1 286 ? -9.06317  4.82563  19.85264  1.000 33.89344  ? 286 LEU A CD2  1 
ATOM   4343 H H    . LEU A 1 286 ? -7.58983  7.00729  23.17575  1.000 24.61234  ? 286 LEU A H    1 
ATOM   4344 H HA   . LEU A 1 286 ? -6.71585  5.27151  21.28646  1.000 25.52464  ? 286 LEU A HA   1 
ATOM   4345 H HB2  . LEU A 1 286 ? -7.92809  7.78243  20.76427  1.000 30.29933  ? 286 LEU A HB2  1 
ATOM   4346 H HB3  . LEU A 1 286 ? -7.35901  6.81383  19.64027  1.000 30.29933  ? 286 LEU A HB3  1 
ATOM   4347 H HG   . LEU A 1 286 ? -9.68424  6.28791  21.13096  1.000 46.99148  ? 286 LEU A HG   1 
ATOM   4348 H HD11 . LEU A 1 286 ? -9.89814  8.05684  19.56275  1.000 39.83231  ? 286 LEU A HD11 1 
ATOM   4349 H HD12 . LEU A 1 286 ? -9.54229  7.01462  18.41792  1.000 39.83231  ? 286 LEU A HD12 1 
ATOM   4350 H HD13 . LEU A 1 286 ? -10.86972 6.83421  19.27167  1.000 39.83231  ? 286 LEU A HD13 1 
ATOM   4351 H HD21 . LEU A 1 286 ? -8.73466  4.29222  20.59322  1.000 40.67213  ? 286 LEU A HD21 1 
ATOM   4352 H HD22 . LEU A 1 286 ? -9.93753  4.50769  19.57824  1.000 40.67213  ? 286 LEU A HD22 1 
ATOM   4353 H HD23 . LEU A 1 286 ? -8.44386  4.77446  19.10782  1.000 40.67213  ? 286 LEU A HD23 1 
ATOM   4354 N N    . LEU A 1 287 ? -4.73196  6.75434  20.58478  1.000 18.20246  ? 287 LEU A N    1 
ATOM   4355 C CA   . LEU A 1 287 ? -3.48597  7.50645  20.48054  1.000 19.36960  ? 287 LEU A CA   1 
ATOM   4356 C C    . LEU A 1 287 ? -3.78507  8.84419  19.79301  1.000 18.30443  ? 287 LEU A C    1 
ATOM   4357 O O    . LEU A 1 287 ? -4.26121  8.87581  18.64135  1.000 25.69264  ? 287 LEU A O    1 
ATOM   4358 C CB   . LEU A 1 287 ? -2.45907  6.69550  19.67593  1.000 20.44360  ? 287 LEU A CB   1 
ATOM   4359 C CG   . LEU A 1 287 ? -2.17695  5.30970  20.28670  1.000 20.48449  ? 287 LEU A CG   1 
ATOM   4360 C CD1  . LEU A 1 287 ? -1.28926  4.46839  19.37778  1.000 27.87733  ? 287 LEU A CD1  1 
ATOM   4361 C CD2  . LEU A 1 287 ? -1.55943  5.44416  21.65277  1.000 26.34406  ? 287 LEU A CD2  1 
ATOM   4362 H H    . LEU A 1 287 ? -4.84307  6.15869  19.97448  1.000 21.84295  ? 287 LEU A H    1 
ATOM   4363 H HA   . LEU A 1 287 ? -3.11520  7.68017  21.35988  1.000 23.24352  ? 287 LEU A HA   1 
ATOM   4364 H HB2  . LEU A 1 287 ? -2.79750  6.56395  18.77645  1.000 24.53232  ? 287 LEU A HB2  1 
ATOM   4365 H HB3  . LEU A 1 287 ? -1.62322  7.18685  19.64735  1.000 24.53232  ? 287 LEU A HB3  1 
ATOM   4366 H HG   . LEU A 1 287 ? -3.02218  4.84309  20.38027  1.000 24.58138  ? 287 LEU A HG   1 
ATOM   4367 H HD11 . LEU A 1 287 ? -1.61283  4.53991  18.46614  1.000 33.45280  ? 287 LEU A HD11 1 
ATOM   4368 H HD12 . LEU A 1 287 ? -0.37868  4.79815  19.43242  1.000 33.45280  ? 287 LEU A HD12 1 
ATOM   4369 H HD13 . LEU A 1 287 ? -1.32438  3.54401  19.66967  1.000 33.45280  ? 287 LEU A HD13 1 
ATOM   4370 H HD21 . LEU A 1 287 ? -2.22255  5.79856  22.26560  1.000 31.61287  ? 287 LEU A HD21 1 
ATOM   4371 H HD22 . LEU A 1 287 ? -1.26468  4.57033  21.95349  1.000 31.61287  ? 287 LEU A HD22 1 
ATOM   4372 H HD23 . LEU A 1 287 ? -0.80238  6.04822  21.59905  1.000 31.61287  ? 287 LEU A HD23 1 
ATOM   4373 N N    . GLU A 1 288 ? -3.49991  9.92729  20.48056  1.000 18.54352  ? 288 GLU A N    1 
ATOM   4374 C CA   A GLU A 1 288 ? -3.86156  11.27270 20.04363  0.500 15.98440  ? 288 GLU A CA   1 
ATOM   4375 C CA   B GLU A 1 288 ? -3.86553  11.26840 20.03672  0.500 15.98167  ? 288 GLU A CA   1 
ATOM   4376 C C    . GLU A 1 288 ? -2.73297  11.90411 19.23817  1.000 18.31027  ? 288 GLU A C    1 
ATOM   4377 O O    . GLU A 1 288 ? -1.56121  11.90667 19.66023  1.000 17.34733  ? 288 GLU A O    1 
ATOM   4378 C CB   A GLU A 1 288 ? -4.15117  12.12359 21.27808  0.500 18.24242  ? 288 GLU A CB   1 
ATOM   4379 C CB   B GLU A 1 288 ? -4.21670  12.13667 21.23915  0.500 18.28943  ? 288 GLU A CB   1 
ATOM   4380 C CG   A GLU A 1 288 ? -4.31889  13.61534 21.03322  0.500 20.07430  ? 288 GLU A CG   1 
ATOM   4381 C CG   B GLU A 1 288 ? -5.37802  11.59151 22.08998  0.500 18.48906  ? 288 GLU A CG   1 
ATOM   4382 C CD   A GLU A 1 288 ? -5.64835  13.96740 20.39927  0.500 28.23308  ? 288 GLU A CD   1 
ATOM   4383 C CD   B GLU A 1 288 ? -6.71686  11.59919 21.38279  0.500 28.95672  ? 288 GLU A CD   1 
ATOM   4384 O OE1  A GLU A 1 288 ? -6.68354  13.48119 20.90151  0.500 21.62529  ? 288 GLU A OE1  1 
ATOM   4385 O OE1  B GLU A 1 288 ? -6.84465  12.24791 20.32266  0.500 23.34929  ? 288 GLU A OE1  1 
ATOM   4386 O OE2  A GLU A 1 288 ? -5.63887  14.71849 19.40316  0.500 18.59238  ? 288 GLU A OE2  1 
ATOM   4387 O OE2  B GLU A 1 288 ? -7.65653  10.96275 21.89466  0.500 25.12611  ? 288 GLU A OE2  1 
ATOM   4388 H H    . GLU A 1 288 ? -3.08216  9.91665  21.23221  1.000 22.25223  ? 288 GLU A H    1 
ATOM   4389 H HA   . GLU A 1 288 ? -4.64156  11.23396 19.46831  1.000 19.17800  ? 288 GLU A HA   1 
ATOM   4390 H HB2  A GLU A 1 288 ? -4.97431  11.80460 21.68006  0.500 21.89090  ? 288 GLU A HB2  1 
ATOM   4391 H HB2  B GLU A 1 288 ? -3.43711  12.20304 21.81250  0.500 21.94732  ? 288 GLU A HB2  1 
ATOM   4392 H HB3  A GLU A 1 288 ? -3.41475  12.01607 21.90019  0.500 21.89090  ? 288 GLU A HB3  1 
ATOM   4393 H HB3  B GLU A 1 288 ? -4.47151  13.01737 20.92239  0.500 21.94732  ? 288 GLU A HB3  1 
ATOM   4394 H HG2  A GLU A 1 288 ? -4.25969  14.08220 21.88142  0.500 24.08916  ? 288 GLU A HG2  1 
ATOM   4395 H HG2  B GLU A 1 288 ? -5.17997  10.67429 22.33569  0.500 22.18687  ? 288 GLU A HG2  1 
ATOM   4396 H HG3  A GLU A 1 288 ? -3.61504  13.91779 20.43823  0.500 24.08916  ? 288 GLU A HG3  1 
ATOM   4397 H HG3  B GLU A 1 288 ? -5.46286  12.13760 22.88716  0.500 22.18687  ? 288 GLU A HG3  1 
ATOM   4398 N N    . ASP A 1 289 ? -3.08275  12.45782 18.05012  1.000 16.74128  ? 289 ASP A N    1 
ATOM   4399 C CA   . ASP A 1 289 ? -2.07380  13.01062 17.15801  1.000 16.88429  ? 289 ASP A CA   1 
ATOM   4400 C C    . ASP A 1 289 ? -2.26718  14.49292 16.82898  1.000 15.73655  ? 289 ASP A C    1 
ATOM   4401 O O    . ASP A 1 289 ? -1.63840  14.98520 15.87650  1.000 16.87755  ? 289 ASP A O    1 
ATOM   4402 C CB   . ASP A 1 289 ? -1.94057  12.17441 15.88400  1.000 16.70732  ? 289 ASP A CB   1 
ATOM   4403 C CG   . ASP A 1 289 ? -3.04092  12.46590 14.83305  1.000 17.96573  ? 289 ASP A CG   1 
ATOM   4404 O OD1  . ASP A 1 289 ? -4.09391  13.04173 15.19174  1.000 19.81446  ? 289 ASP A OD1  1 
ATOM   4405 O OD2  . ASP A 1 289 ? -2.80303  12.11776 13.65123  1.000 18.27332  ? 289 ASP A OD2  1 
ATOM   4406 H H    . ASP A 1 289 ? -3.88948  12.51633 17.75795  1.000 20.08953  ? 289 ASP A H    1 
ATOM   4407 H HA   . ASP A 1 289 ? -1.22888  12.95864 17.63162  1.000 20.26114  ? 289 ASP A HA   1 
ATOM   4408 H HB2  . ASP A 1 289 ? -1.08188  12.36318 15.47422  1.000 20.04878  ? 289 ASP A HB2  1 
ATOM   4409 H HB3  . ASP A 1 289 ? -1.99664  11.23499 16.11906  1.000 20.04878  ? 289 ASP A HB3  1 
ATOM   4410 N N    . GLU A 1 290 ? -3.06006  15.22529 17.59571  1.000 17.24543  ? 290 GLU A N    1 
ATOM   4411 C CA   . GLU A 1 290 ? -3.28239  16.63974 17.30830  1.000 17.59898  ? 290 GLU A CA   1 
ATOM   4412 C C    . GLU A 1 290 ? -2.59990  17.58409 18.29101  1.000 19.18223  ? 290 GLU A C    1 
ATOM   4413 O O    . GLU A 1 290 ? -2.98675  18.75072 18.40167  1.000 20.87944  ? 290 GLU A O    1 
ATOM   4414 C CB   . GLU A 1 290 ? -4.78852  16.94279 17.13668  1.000 20.68559  ? 290 GLU A CB   1 
ATOM   4415 C CG   . GLU A 1 290 ? -5.40820  16.15938 15.94085  1.000 24.50267  ? 290 GLU A CG   1 
ATOM   4416 C CD   . GLU A 1 290 ? -6.52703  16.90691 15.19606  1.000 34.66273  ? 290 GLU A CD   1 
ATOM   4417 O OE1  . GLU A 1 290 ? -7.00634  17.95933 15.70693  1.000 30.40330  ? 290 GLU A OE1  1 
ATOM   4418 O OE2  . GLU A 1 290 ? -6.94937  16.42381 14.07858  1.000 23.78271  ? 290 GLU A OE2  1 
ATOM   4419 H H    . GLU A 1 290 ? -3.47990  14.92978 18.28564  1.000 20.69452  ? 290 GLU A H    1 
ATOM   4420 H HA   . GLU A 1 290 ? -2.87010  16.83222 16.45164  1.000 21.11877  ? 290 GLU A HA   1 
ATOM   4421 H HB2  . GLU A 1 290 ? -5.25942  16.68575 17.94482  1.000 24.82271  ? 290 GLU A HB2  1 
ATOM   4422 H HB3  . GLU A 1 290 ? -4.90594  17.89144 16.97178  1.000 24.82271  ? 290 GLU A HB3  1 
ATOM   4423 H HG2  . GLU A 1 290 ? -4.70623  15.96970 15.29886  1.000 29.40320  ? 290 GLU A HG2  1 
ATOM   4424 H HG3  . GLU A 1 290 ? -5.78397  15.33037 16.27618  1.000 29.40320  ? 290 GLU A HG3  1 
ATOM   4425 N N    . PHE A 1 291 ? -1.52711  17.12768 18.97098  1.000 15.58632  ? 291 PHE A N    1 
ATOM   4426 C CA   . PHE A 1 291 ? -0.65193  17.98670 19.75047  1.000 17.25299  ? 291 PHE A CA   1 
ATOM   4427 C C    . PHE A 1 291 ? 0.75595   17.95574 19.14661  1.000 17.74944  ? 291 PHE A C    1 
ATOM   4428 O O    . PHE A 1 291 ? 1.35605   16.88220 19.03160  1.000 17.53957  ? 291 PHE A O    1 
ATOM   4429 C CB   . PHE A 1 291 ? -0.56960  17.49160 21.22649  1.000 16.33292  ? 291 PHE A CB   1 
ATOM   4430 C CG   . PHE A 1 291 ? -1.84262  17.57353 21.97486  1.000 21.13606  ? 291 PHE A CG   1 
ATOM   4431 C CD1  . PHE A 1 291 ? -2.19357  18.76787 22.58577  1.000 28.25698  ? 291 PHE A CD1  1 
ATOM   4432 C CD2  . PHE A 1 291 ? -2.66865  16.48327 22.08672  1.000 23.96360  ? 291 PHE A CD2  1 
ATOM   4433 C CE1  . PHE A 1 291 ? -3.38009  18.84978 23.32372  1.000 30.68179  ? 291 PHE A CE1  1 
ATOM   4434 C CE2  . PHE A 1 291 ? -3.85067  16.56570 22.82604  1.000 36.75612  ? 291 PHE A CE2  1 
ATOM   4435 C CZ   . PHE A 1 291 ? -4.18874  17.74620 23.42834  1.000 25.29933  ? 291 PHE A CZ   1 
ATOM   4436 H H    . PHE A 1 291 ? -1.29176  16.30068 18.98747  1.000 18.70359  ? 291 PHE A H    1 
ATOM   4437 H HA   . PHE A 1 291 ? -0.99548  18.89328 19.71931  1.000 20.70359  ? 291 PHE A HA   1 
ATOM   4438 H HB2  . PHE A 1 291 ? -0.29021  16.56271 21.22536  1.000 19.59951  ? 291 PHE A HB2  1 
ATOM   4439 H HB3  . PHE A 1 291 ? 0.08227   18.03354 21.69794  1.000 19.59951  ? 291 PHE A HB3  1 
ATOM   4440 H HD1  . PHE A 1 291 ? -1.64211  19.51240 22.50539  1.000 33.90837  ? 291 PHE A HD1  1 
ATOM   4441 H HD2  . PHE A 1 291 ? -2.44001  15.68505 21.66783  1.000 28.75633  ? 291 PHE A HD2  1 
ATOM   4442 H HE1  . PHE A 1 291 ? -3.61865  19.64640 23.74011  1.000 36.81814  ? 291 PHE A HE1  1 
ATOM   4443 H HE2  . PHE A 1 291 ? -4.40416  15.82288 22.90826  1.000 44.10734  ? 291 PHE A HE2  1 
ATOM   4444 H HZ   . PHE A 1 291 ? -4.97860  17.80176 23.91613  1.000 30.35920  ? 291 PHE A HZ   1 
ATOM   4445 N N    . THR A 1 292 ? 1.26590   19.12368 18.78582  1.000 16.63502  ? 292 THR A N    1 
ATOM   4446 C CA   . THR A 1 292 ? 2.62272   19.18793 18.28030  1.000 15.67247  ? 292 THR A CA   1 
ATOM   4447 C C    . THR A 1 292 ? 3.60401   19.15461 19.43522  1.000 16.78636  ? 292 THR A C    1 
ATOM   4448 O O    . THR A 1 292 ? 3.24250   19.41762 20.58896  1.000 16.39637  ? 292 THR A O    1 
ATOM   4449 C CB   . THR A 1 292 ? 2.86380   20.46881 17.50735  1.000 18.30013  ? 292 THR A CB   1 
ATOM   4450 O OG1  . THR A 1 292 ? 2.72100   21.56581 18.40330  1.000 19.37777  ? 292 THR A OG1  1 
ATOM   4451 C CG2  . THR A 1 292 ? 1.89125   20.56992 16.32218  1.000 17.15564  ? 292 THR A CG2  1 
ATOM   4452 H H    . THR A 1 292 ? 0.85310   19.87716 18.82418  1.000 19.96202  ? 292 THR A H    1 
ATOM   4453 H HA   . THR A 1 292 ? 2.76486   18.43511 17.68535  1.000 18.80696  ? 292 THR A HA   1 
ATOM   4454 H HB   . THR A 1 292 ? 3.75747   20.49021 17.13080  1.000 21.96015  ? 292 THR A HB   1 
ATOM   4455 H HG1  . THR A 1 292 ? 3.47374   21.79911 18.69410  1.000 23.25333  ? 292 THR A HG1  1 
ATOM   4456 H HG21 . THR A 1 292 ? 2.06656   21.37939 15.81728  1.000 20.58676  ? 292 THR A HG21 1 
ATOM   4457 H HG22 . THR A 1 292 ? 2.00056   19.80404 15.73704  1.000 20.58676  ? 292 THR A HG22 1 
ATOM   4458 H HG23 . THR A 1 292 ? 0.97662   20.59182 16.64449  1.000 20.58676  ? 292 THR A HG23 1 
ATOM   4459 N N    . PRO A 1 293 ? 4.85756   18.89117 19.17397  1.000 15.43180  ? 293 PRO A N    1 
ATOM   4460 C CA   . PRO A 1 293 ? 5.87666   19.00471 20.24001  1.000 17.09501  ? 293 PRO A CA   1 
ATOM   4461 C C    . PRO A 1 293 ? 5.85971   20.36901 20.89159  1.000 18.08860  ? 293 PRO A C    1 
ATOM   4462 O O    . PRO A 1 293 ? 5.99157   20.46260 22.11666  1.000 18.27407  ? 293 PRO A O    1 
ATOM   4463 C CB   . PRO A 1 293 ? 7.16772   18.68969 19.48837  1.000 20.30591  ? 293 PRO A CB   1 
ATOM   4464 C CG   . PRO A 1 293 ? 6.75183   17.76668 18.39749  1.000 22.43071  ? 293 PRO A CG   1 
ATOM   4465 C CD   . PRO A 1 293 ? 5.39798   18.25278 17.94719  1.000 17.62464  ? 293 PRO A CD   1 
ATOM   4466 H HA   . PRO A 1 293 ? 5.76319   18.33036 20.92796  1.000 20.51401  ? 293 PRO A HA   1 
ATOM   4467 H HB2  . PRO A 1 293 ? 7.54924   19.50550 19.12809  1.000 24.36709  ? 293 PRO A HB2  1 
ATOM   4468 H HB3  . PRO A 1 293 ? 7.80230   18.26156 20.08412  1.000 24.36709  ? 293 PRO A HB3  1 
ATOM   4469 H HG2  . PRO A 1 293 ? 7.39220   17.80902 17.67015  1.000 26.91685  ? 293 PRO A HG2  1 
ATOM   4470 H HG3  . PRO A 1 293 ? 6.69627   16.86021 18.73826  1.000 26.91685  ? 293 PRO A HG3  1 
ATOM   4471 H HD2  . PRO A 1 293 ? 5.48177   18.89779 17.22758  1.000 21.14957  ? 293 PRO A HD2  1 
ATOM   4472 H HD3  . PRO A 1 293 ? 4.83864   17.51210 17.66535  1.000 21.14957  ? 293 PRO A HD3  1 
ATOM   4473 N N    . PHE A 1 294 ? 5.64303   21.43830 20.11151  1.000 20.48470  ? 294 PHE A N    1 
ATOM   4474 C CA   . PHE A 1 294 ? 5.55938   22.78044 20.68292  1.000 23.64401  ? 294 PHE A CA   1 
ATOM   4475 C C    . PHE A 1 294 ? 4.36098   22.93319 21.59343  1.000 18.90193  ? 294 PHE A C    1 
ATOM   4476 O O    . PHE A 1 294 ? 4.47095   23.54412 22.67095  1.000 21.60208  ? 294 PHE A O    1 
ATOM   4477 C CB   . PHE A 1 294 ? 5.47219   23.80804 19.53996  1.000 25.54196  ? 294 PHE A CB   1 
ATOM   4478 C CG   . PHE A 1 294 ? 5.20885   25.22311 20.00127  1.000 38.32896  ? 294 PHE A CG   1 
ATOM   4479 C CD1  . PHE A 1 294 ? 3.91635   25.65338 20.29352  1.000 49.35519  ? 294 PHE A CD1  1 
ATOM   4480 C CD2  . PHE A 1 294 ? 6.24726   26.12423 20.12602  1.000 53.06255  ? 294 PHE A CD2  1 
ATOM   4481 C CE1  . PHE A 1 294 ? 3.67570   26.95261 20.72319  1.000 52.03488  ? 294 PHE A CE1  1 
ATOM   4482 C CE2  . PHE A 1 294 ? 6.01106   27.42436 20.55438  1.000 50.11086  ? 294 PHE A CE2  1 
ATOM   4483 C CZ   . PHE A 1 294 ? 4.72778   27.83375 20.85195  1.000 40.92767  ? 294 PHE A CZ   1 
ATOM   4484 H H    . PHE A 1 294 ? 5.54257   21.41003 19.25786  1.000 24.58163  ? 294 PHE A H    1 
ATOM   4485 H HA   . PHE A 1 294 ? 6.35716   22.94383 21.20994  1.000 28.37281  ? 294 PHE A HA   1 
ATOM   4486 H HB2  . PHE A 1 294 ? 6.31333   23.80736 19.05686  1.000 30.65035  ? 294 PHE A HB2  1 
ATOM   4487 H HB3  . PHE A 1 294 ? 4.74868   23.55210 18.94672  1.000 30.65035  ? 294 PHE A HB3  1 
ATOM   4488 H HD1  . PHE A 1 294 ? 3.20440   25.06244 20.19964  1.000 59.22622  ? 294 PHE A HD1  1 
ATOM   4489 H HD2  . PHE A 1 294 ? 7.11441   25.85793 19.92102  1.000 63.67506  ? 294 PHE A HD2  1 
ATOM   4490 H HE1  . PHE A 1 294 ? 2.80955   27.22619 20.92280  1.000 62.44185  ? 294 PHE A HE1  1 
ATOM   4491 H HE2  . PHE A 1 294 ? 6.71982   28.02026 20.64076  1.000 60.13304  ? 294 PHE A HE2  1 
ATOM   4492 H HZ   . PHE A 1 294 ? 4.57246   28.70444 21.13950  1.000 49.11320  ? 294 PHE A HZ   1 
ATOM   4493 N N    . ASP A 1 295 ? 3.20229   22.40419 21.19240  1.000 18.19859  ? 295 ASP A N    1 
ATOM   4494 C CA   . ASP A 1 295 ? 2.02425   22.45427 22.03677  1.000 18.92446  ? 295 ASP A CA   1 
ATOM   4495 C C    . ASP A 1 295 ? 2.30907   21.79078 23.38773  1.000 19.31022  ? 295 ASP A C    1 
ATOM   4496 O O    . ASP A 1 295 ? 1.86147   22.26883 24.43839  1.000 20.47834  ? 295 ASP A O    1 
ATOM   4497 C CB   . ASP A 1 295 ? 0.85406   21.72810 21.38272  1.000 19.61118  ? 295 ASP A CB   1 
ATOM   4498 C CG   . ASP A 1 295 ? 0.38042   22.39063 20.10351  1.000 28.29784  ? 295 ASP A CG   1 
ATOM   4499 O OD1  . ASP A 1 295 ? 0.67596   23.57928 19.91496  1.000 24.32714  ? 295 ASP A OD1  1 
ATOM   4500 O OD2  . ASP A 1 295 ? -0.28812  21.69953 19.28952  1.000 22.90246  ? 295 ASP A OD2  1 
ATOM   4501 H H    . ASP A 1 295 ? 3.07837   22.01291 20.43666  1.000 21.83831  ? 295 ASP A H    1 
ATOM   4502 H HA   . ASP A 1 295 ? 1.78224   23.38537 22.16077  1.000 22.70936  ? 295 ASP A HA   1 
ATOM   4503 H HB2  . ASP A 1 295 ? 1.12706   20.82284 21.16625  1.000 23.53341  ? 295 ASP A HB2  1 
ATOM   4504 H HB3  . ASP A 1 295 ? 0.10856   21.71042 22.00306  1.000 23.53341  ? 295 ASP A HB3  1 
ATOM   4505 N N    . VAL A 1 296 ? 3.03466   20.66393 23.36986  1.000 17.39655  ? 296 VAL A N    1 
ATOM   4506 C CA   . VAL A 1 296 ? 3.34658   19.95725 24.60924  1.000 19.29534  ? 296 VAL A CA   1 
ATOM   4507 C C    . VAL A 1 296 ? 4.29237   20.78559 25.47941  1.000 20.32303  ? 296 VAL A C    1 
ATOM   4508 O O    . VAL A 1 296 ? 4.05686   20.96955 26.67931  1.000 21.31068  ? 296 VAL A O    1 
ATOM   4509 C CB   . VAL A 1 296 ? 3.90776   18.55606 24.30899  1.000 18.23572  ? 296 VAL A CB   1 
ATOM   4510 C CG1  . VAL A 1 296 ? 4.43194   17.89260 25.62467  1.000 19.68067  ? 296 VAL A CG1  1 
ATOM   4511 C CG2  . VAL A 1 296 ? 2.86412   17.69712 23.66724  1.000 17.93841  ? 296 VAL A CG2  1 
ATOM   4512 H H    . VAL A 1 296 ? 3.35220   20.29584 22.66044  1.000 20.87586  ? 296 VAL A H    1 
ATOM   4513 H HA   . VAL A 1 296 ? 2.52386   19.83853 25.10918  1.000 23.15441  ? 296 VAL A HA   1 
ATOM   4514 H HB   . VAL A 1 296 ? 4.64976   18.63904 23.68976  1.000 21.88287  ? 296 VAL A HB   1 
ATOM   4515 H HG11 . VAL A 1 296 ? 5.20506   18.38581 25.94076  1.000 23.61681  ? 296 VAL A HG11 1 
ATOM   4516 H HG12 . VAL A 1 296 ? 3.72869   17.91654 26.29233  1.000 23.61681  ? 296 VAL A HG12 1 
ATOM   4517 H HG13 . VAL A 1 296 ? 4.67960   16.97352 25.43793  1.000 23.61681  ? 296 VAL A HG13 1 
ATOM   4518 H HG21 . VAL A 1 296 ? 1.98721   18.05095 23.88342  1.000 21.52609  ? 296 VAL A HG21 1 
ATOM   4519 H HG22 . VAL A 1 296 ? 2.99613   17.70458 22.70629  1.000 21.52609  ? 296 VAL A HG22 1 
ATOM   4520 H HG23 . VAL A 1 296 ? 2.94821   16.79197 24.00566  1.000 21.52609  ? 296 VAL A HG23 1 
ATOM   4521 N N    . VAL A 1 297 ? 5.36075   21.30057 24.90661  1.000 19.54215  ? 297 VAL A N    1 
ATOM   4522 C CA   . VAL A 1 297 ? 6.29594   22.12679 25.66659  1.000 24.03545  ? 297 VAL A CA   1 
ATOM   4523 C C    . VAL A 1 297 ? 5.60268   23.37078 26.21566  1.000 31.30799  ? 297 VAL A C    1 
ATOM   4524 O O    . VAL A 1 297 ? 5.84483   23.76340 27.36682  1.000 28.37327  ? 297 VAL A O    1 
ATOM   4525 C CB   . VAL A 1 297 ? 7.52352   22.48849 24.81028  1.000 25.42458  ? 297 VAL A CB   1 
ATOM   4526 C CG1  . VAL A 1 297 ? 8.41114   23.45971 25.56529  1.000 29.70949  ? 297 VAL A CG1  1 
ATOM   4527 C CG2  . VAL A 1 297 ? 8.29616   21.24299 24.45260  1.000 31.69524  ? 297 VAL A CG2  1 
ATOM   4528 H H    . VAL A 1 297 ? 5.57440   21.19181 24.08070  1.000 23.45058  ? 297 VAL A H    1 
ATOM   4529 H HA   . VAL A 1 297 ? 6.60677   21.60605 26.42363  1.000 28.84254  ? 297 VAL A HA   1 
ATOM   4530 H HB   . VAL A 1 297 ? 7.22848   22.91095 23.98847  1.000 30.50949  ? 297 VAL A HB   1 
ATOM   4531 H HG11 . VAL A 1 297 ? 9.29696   23.45058 25.17013  1.000 35.65139  ? 297 VAL A HG11 1 
ATOM   4532 H HG12 . VAL A 1 297 ? 8.03025   24.34961 25.50286  1.000 35.65139  ? 297 VAL A HG12 1 
ATOM   4533 H HG13 . VAL A 1 297 ? 8.46058   23.18550 26.49441  1.000 35.65139  ? 297 VAL A HG13 1 
ATOM   4534 H HG21 . VAL A 1 297 ? 8.92531   21.45393 23.74508  1.000 38.03429  ? 297 VAL A HG21 1 
ATOM   4535 H HG22 . VAL A 1 297 ? 8.77333   20.93108 25.23741  1.000 38.03429  ? 297 VAL A HG22 1 
ATOM   4536 H HG23 . VAL A 1 297 ? 7.67504   20.56184 24.15070  1.000 38.03429  ? 297 VAL A HG23 1 
ATOM   4537 N N    . ARG A 1 298 ? 4.74564   24.00484 25.40294  1.000 27.59396  ? 298 ARG A N    1 
ATOM   4538 C CA   . ARG A 1 298 ? 4.03653   25.22074 25.81262  1.000 33.92025  ? 298 ARG A CA   1 
ATOM   4539 C C    . ARG A 1 298 ? 3.24093   24.97497 27.07846  1.000 35.62031  ? 298 ARG A C    1 
ATOM   4540 O O    . ARG A 1 298 ? 3.22483   25.81462 27.98864  1.000 37.76559  ? 298 ARG A O    1 
ATOM   4541 C CB   . ARG A 1 298 ? 3.07895   25.68361 24.69884  1.000 36.07782  ? 298 ARG A CB   1 
ATOM   4542 C CG   . ARG A 1 298 ? 2.41244   27.06249 24.91454  1.000 52.93862  ? 298 ARG A CG   1 
ATOM   4543 C CD   . ARG A 1 298 ? 0.85170   27.06919 24.85668  1.000 73.27352  ? 298 ARG A CD   1 
ATOM   4544 N NE   . ARG A 1 298 ? 0.27143   26.53271 23.62223  1.000 75.95679  ? 298 ARG A NE   1 
ATOM   4545 C CZ   . ARG A 1 298 ? -0.98133  26.73879 23.21084  1.000 49.55271  ? 298 ARG A CZ   1 
ATOM   4546 N NH1  . ARG A 1 298 ? -1.81205  27.54395 23.86168  1.000 52.37814  ? 298 ARG A NH1  1 
ATOM   4547 N NH2  . ARG A 1 298 ? -1.40913  26.13463 22.10390  1.000 55.36722  ? 298 ARG A NH2  1 
ATOM   4548 H H    . ARG A 1 298 ? 4.55647   23.74900 24.60397  1.000 33.11275  ? 298 ARG A H    1 
ATOM   4549 H HA   . ARG A 1 298 ? 4.69068   25.91931 25.97069  1.000 40.70430  ? 298 ARG A HA   1 
ATOM   4550 H HB2  . ARG A 1 298 ? 3.57902   25.73273 23.86913  1.000 43.29339  ? 298 ARG A HB2  1 
ATOM   4551 H HB3  . ARG A 1 298 ? 2.36705   25.02961 24.61893  1.000 43.29339  ? 298 ARG A HB3  1 
ATOM   4552 H HG2  . ARG A 1 298 ? 2.66971   27.39349 25.78927  1.000 63.52634  ? 298 ARG A HG2  1 
ATOM   4553 H HG3  . ARG A 1 298 ? 2.72888   27.66680 24.22491  1.000 63.52634  ? 298 ARG A HG3  1 
ATOM   4554 H HD2  . ARG A 1 298 ? 0.51496   26.53309 25.59160  1.000 87.92823  ? 298 ARG A HD2  1 
ATOM   4555 H HD3  . ARG A 1 298 ? 0.54511   27.98507 24.94642  1.000 87.92823  ? 298 ARG A HD3  1 
ATOM   4556 H HE   . ARG A 1 298 ? 0.77758   26.04742 23.12433  1.000 91.14815  ? 298 ARG A HE   1 
ATOM   4557 H HH11 . ARG A 1 298 ? -1.54803  27.95150 24.57147  1.000 62.85377  ? 298 ARG A HH11 1 
ATOM   4558 H HH12 . ARG A 1 298 ? -2.61427  27.65805 23.57356  1.000 62.85377  ? 298 ARG A HH12 1 
ATOM   4559 H HH21 . ARG A 1 298 ? -0.88011  25.61903 21.66357  1.000 66.44066  ? 298 ARG A HH21 1 
ATOM   4560 H HH22 . ARG A 1 298 ? -2.21442  26.26006 21.82937  1.000 66.44066  ? 298 ARG A HH22 1 
ATOM   4561 N N    . GLN A 1 299 ? 2.57727   23.82817 27.16199  1.000 34.10808  ? 299 GLN A N    1 
ATOM   4562 C CA   . GLN A 1 299 ? 1.67141   23.53750 28.25939  1.000 34.80827  ? 299 GLN A CA   1 
ATOM   4563 C C    . GLN A 1 299 ? 2.36441   22.87445 29.43752  1.000 34.72151  ? 299 GLN A C    1 
ATOM   4564 O O    . GLN A 1 299 ? 2.09272   23.24178 30.58158  1.000 50.50893  ? 299 GLN A O    1 
ATOM   4565 C CB   . GLN A 1 299 ? 0.53190   22.64535 27.77129  1.000 31.40152  ? 299 GLN A CB   1 
ATOM   4566 C CG   . GLN A 1 299 ? -0.75659  22.89457 28.41524  1.000 22.86254  ? 299 GLN A CG   1 
ATOM   4567 C CD   . GLN A 1 299 ? -1.86143  22.01397 27.93571  1.000 24.17808  ? 299 GLN A CD   1 
ATOM   4568 O OE1  . GLN A 1 299 ? -2.60403  21.45096 28.73244  1.000 21.94714  ? 299 GLN A OE1  1 
ATOM   4569 N NE2  . GLN A 1 299 ? -1.99586  21.87606 26.62042  1.000 20.30743  ? 299 GLN A NE2  1 
ATOM   4570 H H    . GLN A 1 299 ? 2.63684   23.19312 26.58513  1.000 40.92970  ? 299 GLN A H    1 
ATOM   4571 H HA   . GLN A 1 299 ? 1.29454   24.37465 28.57251  1.000 41.76992  ? 299 GLN A HA   1 
ATOM   4572 H HB2  . GLN A 1 299 ? 0.41510   22.78782 26.81894  1.000 37.68182  ? 299 GLN A HB2  1 
ATOM   4573 H HB3  . GLN A 1 299 ? 0.76978   21.72054 27.94167  1.000 37.68182  ? 299 GLN A HB3  1 
ATOM   4574 H HG2  . GLN A 1 299 ? -0.65961  22.75070 29.36960  1.000 27.43505  ? 299 GLN A HG2  1 
ATOM   4575 H HG3  . GLN A 1 299 ? -1.01722  23.81288 28.24297  1.000 27.43505  ? 299 GLN A HG3  1 
ATOM   4576 H HE21 . GLN A 1 299 ? -1.45870  22.28545 26.08801  1.000 24.36891  ? 299 GLN A HE21 1 
ATOM   4577 H HE22 . GLN A 1 299 ? -2.61998  21.37744 26.30191  1.000 24.36891  ? 299 GLN A HE22 1 
ATOM   4578 N N    . CYS A 1 300 ? 3.25115   21.91086 29.19685  1.000 31.89839  ? 300 CYS A N    1 
ATOM   4579 C CA   . CYS A 1 300 ? 3.94178   21.17637 30.23098  1.000 32.76506  ? 300 CYS A CA   1 
ATOM   4580 C C    . CYS A 1 300 ? 5.21377   21.92088 30.67180  1.000 44.91962  ? 300 CYS A C    1 
ATOM   4581 O O    . CYS A 1 300 ? 5.34061   23.12750 30.46124  1.000 51.24323  ? 300 CYS A O    1 
ATOM   4582 C CB   . CYS A 1 300 ? 4.34788   19.78180 29.75001  1.000 24.70427  ? 300 CYS A CB   1 
ATOM   4583 S SG   . CYS A 1 300 ? 3.02723   18.67378 29.21791  1.000 32.18445  ? 300 CYS A SG   1 
ATOM   4584 H H    . CYS A 1 300 ? 3.47433   21.65877 28.40549  1.000 38.27807  ? 300 CYS A H    1 
ATOM   4585 H HA   . CYS A 1 300 ? 3.33728   21.08174 30.98365  1.000 39.31808  ? 300 CYS A HA   1 
ATOM   4586 H HB2  . CYS A 1 300 ? 4.94591   19.88976 28.99397  1.000 29.64512  ? 300 CYS A HB2  1 
ATOM   4587 H HB3  . CYS A 1 300 ? 4.81046   19.33842 30.47825  1.000 29.64512  ? 300 CYS A HB3  1 
ATOM   4588 H HG   . CYS A 1 300 ? 2.52233   19.11694 28.22359  1.000 38.62134  ? 300 CYS A HG   1 
HETATM 4589 C C7   . UED B 2 .   ? -21.41570 21.26179 1.56162   1.000 28.57450  ? 401 UED A C7   1 
HETATM 4590 O O8   . UED B 2 .   ? -21.33622 22.48458 0.82619   1.000 28.02055  ? 401 UED A O8   1 
HETATM 4591 C C9   . UED B 2 .   ? -20.56572 23.46981 1.29374   1.000 29.87230  ? 401 UED A C9   1 
HETATM 4592 O O10  . UED B 2 .   ? -19.96438 23.41669 2.35915   1.000 22.98190  ? 401 UED A O10  1 
HETATM 4593 C C1   . UED B 2 .   ? -22.44264 21.34683 2.68272   1.000 31.40492  ? 401 UED A C1   1 
HETATM 4594 C C2   . UED B 2 .   ? -23.34286 22.42122 2.75465   1.000 34.00886  ? 401 UED A C2   1 
HETATM 4595 C C3   . UED B 2 .   ? -24.28747 22.47958 3.78456   1.000 34.88657  ? 401 UED A C3   1 
HETATM 4596 C C4   . UED B 2 .   ? -24.32843 21.45194 4.73415   1.000 44.66556  ? 401 UED A C4   1 
HETATM 4597 C C5   . UED B 2 .   ? -23.43392 20.37646 4.65634   1.000 43.53478  ? 401 UED A C5   1 
HETATM 4598 C C6   . UED B 2 .   ? -22.48626 20.31986 3.63943   1.000 36.39145  ? 401 UED A C6   1 
HETATM 4599 N N11  . UED B 2 .   ? -20.55838 24.55475 0.42782   1.000 23.31575  ? 401 UED A N11  1 
HETATM 4600 C C12  . UED B 2 .   ? -20.04090 25.83213 0.90205   1.000 19.68027  ? 401 UED A C12  1 
HETATM 4601 C C17  . UED B 2 .   ? -20.74398 26.29164 2.19247   1.000 23.86032  ? 401 UED A C17  1 
HETATM 4602 O O18  . UED B 2 .   ? -21.95481 26.10167 2.35040   1.000 24.41262  ? 401 UED A O18  1 
HETATM 4603 C C13  . UED B 2 .   ? -20.18271 26.89158 -0.22475  1.000 21.15149  ? 401 UED A C13  1 
HETATM 4604 C C14  . UED B 2 .   ? -19.44846 26.47701 -1.50815  1.000 24.62863  ? 401 UED A C14  1 
HETATM 4605 C C15  . UED B 2 .   ? -17.93124 26.33560 -1.28972  1.000 26.12759  ? 401 UED A C15  1 
HETATM 4606 C C16  . UED B 2 .   ? -19.78088 27.45907 -2.66785  1.000 32.01892  ? 401 UED A C16  1 
HETATM 4607 N N19  . UED B 2 .   ? -19.97803 26.86301 3.13696   1.000 19.63716  ? 401 UED A N19  1 
HETATM 4608 C C20  . UED B 2 .   ? -20.45388 27.35100 4.41038   1.000 18.49178  ? 401 UED A C20  1 
HETATM 4609 C C21  . UED B 2 .   ? -20.12410 28.86415 4.58288   1.000 20.79546  ? 401 UED A C21  1 
HETATM 4610 O O22  . UED B 2 .   ? -20.78816 29.34330 5.73726   1.000 24.99794  ? 401 UED A O22  1 
HETATM 4611 C C24  . UED B 2 .   ? -19.94757 26.47573 5.62715   1.000 21.02544  ? 401 UED A C24  1 
HETATM 4612 C C25  . UED B 2 .   ? -20.46037 25.08126 5.61224   1.000 18.98812  ? 401 UED A C25  1 
HETATM 4613 C C26  . UED B 2 .   ? -21.96984 24.84463 5.73721   1.000 24.94995  ? 401 UED A C26  1 
HETATM 4614 C C27  . UED B 2 .   ? -22.12589 23.53696 6.48832   1.000 27.02734  ? 401 UED A C27  1 
HETATM 4615 N N28  . UED B 2 .   ? -20.82205 23.30343 7.13771   1.000 24.84267  ? 401 UED A N28  1 
HETATM 4616 C C29  . UED B 2 .   ? -19.83062 24.18351 6.64982   1.000 24.11826  ? 401 UED A C29  1 
HETATM 4617 O O30  . UED B 2 .   ? -18.66598 24.13105 7.01990   1.000 19.90216  ? 401 UED A O30  1 
HETATM 4618 H H1   . UED B 2 .   ? -20.44095 21.01717 1.98880   1.000 34.28940  ? 401 UED A H1   1 
HETATM 4619 H H2   . UED B 2 .   ? -21.68342 20.43976 0.89449   1.000 34.28940  ? 401 UED A H2   1 
HETATM 4620 H H3   . UED B 2 .   ? -23.31068 23.20867 2.01476   1.000 40.81063  ? 401 UED A H3   1 
HETATM 4621 H H4   . UED B 2 .   ? -24.97870 23.30830 3.84773   1.000 41.86389  ? 401 UED A H4   1 
HETATM 4622 H H5   . UED B 2 .   ? -25.05463 21.48790 5.53274   1.000 53.59867  ? 401 UED A H5   1 
HETATM 4623 H H6   . UED B 2 .   ? -23.47925 19.58455 5.39077   1.000 52.24173  ? 401 UED A H6   1 
HETATM 4624 H H7   . UED B 2 .   ? -21.79224 19.49122 3.59037   1.000 43.66973  ? 401 UED A H7   1 
HETATM 4625 H H8   . UED B 2 .   ? -20.90530 24.46549 -0.51759  1.000 27.97891  ? 401 UED A H8   1 
HETATM 4626 H H9   . UED B 2 .   ? -18.97411 25.73531 1.11939   1.000 23.61633  ? 401 UED A H9   1 
HETATM 4627 H H10  . UED B 2 .   ? -19.80156 27.85458 0.12456   1.000 25.38179  ? 401 UED A H10  1 
HETATM 4628 H H11  . UED B 2 .   ? -21.24068 27.05946 -0.44193  1.000 25.38179  ? 401 UED A H11  1 
HETATM 4629 H H12  . UED B 2 .   ? -19.82583 25.50002 -1.81372  1.000 29.55435  ? 401 UED A H12  1 
HETATM 4630 H H13  . UED B 2 .   ? -17.37184 26.44127 -2.22041  1.000 31.35311  ? 401 UED A H13  1 
HETATM 4631 H H14  . UED B 2 .   ? -17.66646 25.36319 -0.87189  1.000 31.35311  ? 401 UED A H14  1 
HETATM 4632 H H15  . UED B 2 .   ? -17.54436 27.08949 -0.60251  1.000 31.35311  ? 401 UED A H15  1 
HETATM 4633 H H16  . UED B 2 .   ? -20.84603 27.50045 -2.89073  1.000 38.42271  ? 401 UED A H16  1 
HETATM 4634 H H17  . UED B 2 .   ? -19.47805 28.48245 -2.45127  1.000 38.42271  ? 401 UED A H17  1 
HETATM 4635 H H18  . UED B 2 .   ? -19.28777 27.18958 -3.60066  1.000 38.42271  ? 401 UED A H18  1 
HETATM 4636 H H19  . UED B 2 .   ? -18.98919 26.96797 2.96015   1.000 23.56459  ? 401 UED A H19  1 
HETATM 4637 H H20  . UED B 2 .   ? -21.54591 27.30546 4.40428   1.000 22.19014  ? 401 UED A H20  1 
HETATM 4638 H H21  . UED B 2 .   ? -20.23879 26.96699 6.55791   1.000 25.23053  ? 401 UED A H21  1 
HETATM 4639 H H22  . UED B 2 .   ? -18.85560 26.46833 5.62365   1.000 25.23053  ? 401 UED A H22  1 
HETATM 4640 H H23  . UED B 2 .   ? -20.15442 24.66535 4.65115   1.000 22.78574  ? 401 UED A H23  1 
HETATM 4641 H H24  . UED B 2 .   ? -22.46064 24.77616 4.76637   1.000 29.93994  ? 401 UED A H24  1 
HETATM 4642 H H25  . UED B 2 .   ? -22.47181 25.64629 6.27894   1.000 29.93994  ? 401 UED A H25  1 
HETATM 4643 H H26  . UED B 2 .   ? -22.35382 22.70642 5.82022   1.000 32.43281  ? 401 UED A H26  1 
HETATM 4644 H H27  . UED B 2 .   ? -22.90607 23.59213 7.24751   1.000 32.43281  ? 401 UED A H27  1 
HETATM 4645 H H28  . UED B 2 .   ? -20.57995 22.35768 7.39661   1.000 29.81120  ? 401 UED A H28  1 
HETATM 4646 H H31  . UED B 2 .   ? -20.93756 30.29336 5.62439   1.000 29.99753  ? 401 UED A H31  1 
HETATM 4647 O O    . HOH C 3 .   ? -13.03353 11.12793 1.53515   1.000 49.25070  ? 501 HOH A O    1 
HETATM 4648 O O    . HOH C 3 .   ? -21.65105 48.34640 4.46997   1.000 33.19879  ? 502 HOH A O    1 
HETATM 4649 O O    . HOH C 3 .   ? -17.98753 12.84804 -3.38839  1.000 49.90351  ? 503 HOH A O    1 
HETATM 4650 O O    . HOH C 3 .   ? 15.76892  5.95603  27.32448  1.000 31.20158  ? 504 HOH A O    1 
HETATM 4651 O O    . HOH C 3 .   ? -23.98954 36.57972 -7.99257  1.000 40.81402  ? 505 HOH A O    1 
HETATM 4652 O O    . HOH C 3 .   ? 14.10291  4.94086  8.68540   1.000 41.81485  ? 506 HOH A O    1 
HETATM 4653 O O    . HOH C 3 .   ? 10.40569  18.08787 10.40999  1.000 33.87863  ? 507 HOH A O    1 
HETATM 4654 O O    . HOH C 3 .   ? 4.35499   13.95081 10.18660  1.000 36.28760  ? 508 HOH A O    1 
HETATM 4655 O O    . HOH C 3 .   ? -24.52399 48.28389 -9.48252  1.000 38.14910  ? 509 HOH A O    1 
HETATM 4656 O O    . HOH C 3 .   ? -5.56649  8.61814  16.60279  1.000 42.06891  ? 510 HOH A O    1 
HETATM 4657 O O    . HOH C 3 .   ? -21.05717 16.98383 5.48016   1.000 32.42165  ? 511 HOH A O    1 
HETATM 4658 O O    . HOH C 3 .   ? -7.26737  19.37336 17.71332  1.000 29.70578  ? 512 HOH A O    1 
HETATM 4659 O O    . HOH C 3 .   ? -9.32607  53.54160 3.89967   1.000 43.42749  ? 513 HOH A O    1 
HETATM 4660 O O    . HOH C 3 .   ? 4.90817   23.63274 16.02594  1.000 40.39155  ? 514 HOH A O    1 
HETATM 4661 O O    . HOH C 3 .   ? 1.85570   15.11666 6.26358   1.000 37.69354  ? 515 HOH A O    1 
HETATM 4662 O O    . HOH C 3 .   ? -21.36591 48.98739 1.44312   1.000 42.46292  ? 516 HOH A O    1 
HETATM 4663 O O    . HOH C 3 .   ? 2.06195   15.63073 9.05610   1.000 33.66882  ? 517 HOH A O    1 
HETATM 4664 O O    . HOH C 3 .   ? -5.34545  -4.16368 23.95280  1.000 40.43950  ? 518 HOH A O    1 
HETATM 4665 O O    . HOH C 3 .   ? 4.00759   -4.68007 13.53028  1.000 46.47872  ? 519 HOH A O    1 
HETATM 4666 O O    . HOH C 3 .   ? -7.93668  4.61207  32.92321  1.000 48.23266  ? 520 HOH A O    1 
HETATM 4667 O O    . HOH C 3 .   ? -10.079   10.213   21.712    1.000 35.76505  ? 521 HOH A O    1 
HETATM 4668 O O    . HOH C 3 .   ? -19.52497 26.27880 15.21283  1.000 25.74331  ? 522 HOH A O    1 
HETATM 4669 O O    . HOH C 3 .   ? 5.74410   -2.32424 6.89139   1.000 37.14647  ? 523 HOH A O    1 
HETATM 4670 O O    . HOH C 3 .   ? -4.99983  20.25974 18.93476  1.000 42.24991  ? 524 HOH A O    1 
HETATM 4671 O O    . HOH C 3 .   ? 3.07907   30.87191 20.00479  1.000 54.11816  ? 525 HOH A O    1 
HETATM 4672 O O    . HOH C 3 .   ? 12.04150  20.94299 19.52068  1.000 39.05537  ? 526 HOH A O    1 
HETATM 4673 O O    . HOH C 3 .   ? -4.810    29.377   -5.545    1.000 29.08153  ? 527 HOH A O    1 
HETATM 4674 O O    . HOH C 3 .   ? 13.66603  16.82272 33.93418  1.000 47.82155  ? 528 HOH A O    1 
HETATM 4675 O O    . HOH C 3 .   ? -15.114   17.491   13.824    1.000 35.56562  ? 529 HOH A O    1 
HETATM 4676 O O    . HOH C 3 .   ? -23.95736 28.85675 5.15979   1.000 34.99965  ? 530 HOH A O    1 
HETATM 4677 O O    . HOH C 3 .   ? -1.22118  38.65880 -3.85608  1.000 46.68482  ? 531 HOH A O    1 
HETATM 4678 O O    . HOH C 3 .   ? -8.37149  42.97460 18.17697  1.000 29.53882  ? 532 HOH A O    1 
HETATM 4679 O O    . HOH C 3 .   ? 16.22400  1.35535  27.60498  1.000 54.71418  ? 533 HOH A O    1 
HETATM 4680 O O    . HOH C 3 .   ? -7.16258  38.72952 -8.87490  1.000 42.81889  ? 534 HOH A O    1 
HETATM 4681 O O    . HOH C 3 .   ? -1.08043  -2.59657 26.07048  1.000 39.84087  ? 535 HOH A O    1 
HETATM 4682 O O    . HOH C 3 .   ? -11.56948 19.28871 -5.79235  1.000 29.21344  ? 536 HOH A O    1 
HETATM 4683 O O    . HOH C 3 .   ? 16.71543  -5.85534 28.17918  1.000 55.18886  ? 537 HOH A O    1 
HETATM 4684 O O    . HOH C 3 .   ? -13.05690 33.84009 13.18510  1.000 19.02998  ? 538 HOH A O    1 
HETATM 4685 O O    . HOH C 3 .   ? -22.82771 34.23788 9.26155   1.000 23.88280  ? 539 HOH A O    1 
HETATM 4686 O O    . HOH C 3 .   ? -3.16857  -0.40673 16.53764  1.000 36.31979  ? 540 HOH A O    1 
HETATM 4687 O O    . HOH C 3 .   ? -1.44588  25.82719 17.96342  1.000 21.97109  ? 541 HOH A O    1 
HETATM 4688 O O    . HOH C 3 .   ? -8.45699  1.12182  26.76899  1.000 45.14225  ? 542 HOH A O    1 
HETATM 4689 O O    . HOH C 3 .   ? -21.08086 23.45565 15.11424  1.000 31.75966  ? 543 HOH A O    1 
HETATM 4690 O O    . HOH C 3 .   ? 0.40607   15.82515 3.25658   1.000 35.95429  ? 544 HOH A O    1 
HETATM 4691 O O    . HOH C 3 .   ? 6.65958   10.45508 35.00278  1.000 24.04358  ? 545 HOH A O    1 
HETATM 4692 O O    . HOH C 3 .   ? -3.06317  0.18254  8.42669   1.000 53.93435  ? 546 HOH A O    1 
HETATM 4693 O O    . HOH C 3 .   ? -22.79277 38.69103 -9.93697  1.000 34.22603  ? 547 HOH A O    1 
HETATM 4694 O O    . HOH C 3 .   ? 3.80848   18.13760 13.92482  1.000 23.94581  ? 548 HOH A O    1 
HETATM 4695 O O    . HOH C 3 .   ? -10.16945 21.07648 25.51686  1.000 34.53002  ? 549 HOH A O    1 
HETATM 4696 O O    . HOH C 3 .   ? -11.62613 10.55759 -1.63113  1.000 49.26509  ? 550 HOH A O    1 
HETATM 4697 O O    . HOH C 3 .   ? -5.79882  8.38384  31.70879  1.000 33.71279  ? 551 HOH A O    1 
HETATM 4698 O O    . HOH C 3 .   ? -8.22551  18.50369 12.59565  1.000 20.99988  ? 552 HOH A O    1 
HETATM 4699 O O    . HOH C 3 .   ? -10.04179 54.01142 12.71930  1.000 43.56339  ? 553 HOH A O    1 
HETATM 4700 O O    . HOH C 3 .   ? -26.09006 42.75164 -2.51241  1.000 41.57468  ? 554 HOH A O    1 
HETATM 4701 O O    . HOH C 3 .   ? -27.89798 34.66983 9.37608   1.000 50.00114  ? 555 HOH A O    1 
HETATM 4702 O O    . HOH C 3 .   ? -2.51497  32.82099 5.62864   1.000 28.36396  ? 556 HOH A O    1 
HETATM 4703 O O    . HOH C 3 .   ? 10.82285  10.39251 33.51378  1.000 40.54674  ? 557 HOH A O    1 
HETATM 4704 O O    . HOH C 3 .   ? -4.42428  6.77855  14.67548  1.000 38.97129  ? 558 HOH A O    1 
HETATM 4705 O O    . HOH C 3 .   ? 10.83848  18.25403 22.14852  1.000 29.79512  ? 559 HOH A O    1 
HETATM 4706 O O    . HOH C 3 .   ? -16.82571 44.72544 -10.13532 1.000 30.23084  ? 560 HOH A O    1 
HETATM 4707 O O    . HOH C 3 .   ? -3.76193  6.19891  10.60196  1.000 33.04781  ? 561 HOH A O    1 
HETATM 4708 O O    . HOH C 3 .   ? 2.62358   34.86545 15.45665  1.000 27.44888  ? 562 HOH A O    1 
HETATM 4709 O O    . HOH C 3 .   ? 16.58418  13.98879 19.74677  1.000 36.86822  ? 563 HOH A O    1 
HETATM 4710 O O    . HOH C 3 .   ? 9.76466   3.14041  26.73037  1.000 27.69192  ? 564 HOH A O    1 
HETATM 4711 O O    . HOH C 3 .   ? 8.55299   -2.40051 20.67712  1.000 38.47093  ? 565 HOH A O    1 
HETATM 4712 O O    . HOH C 3 .   ? -24.97444 36.28835 -3.15104  1.000 42.39255  ? 566 HOH A O    1 
HETATM 4713 O O    . HOH C 3 .   ? -4.40979  38.48733 1.17650   1.000 35.97234  ? 567 HOH A O    1 
HETATM 4714 O O    . HOH C 3 .   ? -9.78980  18.80972 26.34228  1.000 35.80541  ? 568 HOH A O    1 
HETATM 4715 O O    . HOH C 3 .   ? -24.16150 25.74548 0.83310   1.000 43.13580  ? 569 HOH A O    1 
HETATM 4716 O O    . HOH C 3 .   ? -8.66965  22.65079 3.36719   1.000 17.13113  ? 570 HOH A O    1 
HETATM 4717 O O    . HOH C 3 .   ? 17.23804  17.75938 11.60059  1.000 34.09163  ? 571 HOH A O    1 
HETATM 4718 O O    . HOH C 3 .   ? -2.65791  11.43237 3.82072   1.000 38.78915  ? 572 HOH A O    1 
HETATM 4719 O O    . HOH C 3 .   ? -16.59980 38.62202 20.96472  1.000 37.66119  ? 573 HOH A O    1 
HETATM 4720 O O    . HOH C 3 .   ? 2.30057   24.10356 17.53324  1.000 27.98807  ? 574 HOH A O    1 
HETATM 4721 O O    . HOH C 3 .   ? 4.77745   5.14449  6.92072   1.000 31.64685  ? 575 HOH A O    1 
HETATM 4722 O O    . HOH C 3 .   ? -7.21848  15.42767 0.43133   1.000 27.01017  ? 576 HOH A O    1 
HETATM 4723 O O    . HOH C 3 .   ? -18.17658 47.66134 -9.77228  1.000 33.07917  ? 577 HOH A O    1 
HETATM 4724 O O    . HOH C 3 .   ? -26.27029 28.29972 11.62014  1.000 45.94978  ? 578 HOH A O    1 
HETATM 4725 O O    . HOH C 3 .   ? -18.52973 16.87531 -2.75064  1.000 32.65029  ? 579 HOH A O    1 
HETATM 4726 O O    . HOH C 3 .   ? 7.34808   12.07303 7.54142   1.000 40.54547  ? 580 HOH A O    1 
HETATM 4727 O O    . HOH C 3 .   ? -0.61203  14.48410 19.67755  1.000 15.68863  ? 581 HOH A O    1 
HETATM 4728 O O    . HOH C 3 .   ? 4.16296   19.67751 10.50287  1.000 30.40080  ? 582 HOH A O    1 
HETATM 4729 O O    . HOH C 3 .   ? 11.86324  1.34444  7.39387   1.000 39.31212  ? 583 HOH A O    1 
HETATM 4730 O O    . HOH C 3 .   ? 17.28360  8.36203  15.03791  1.000 35.07098  ? 584 HOH A O    1 
HETATM 4731 O O    . HOH C 3 .   ? -6.09505  15.09758 30.11891  1.000 42.86201  ? 585 HOH A O    1 
HETATM 4732 O O    . HOH C 3 .   ? -9.07406  12.52516 8.46390   1.000 34.18945  ? 586 HOH A O    1 
HETATM 4733 O O    . HOH C 3 .   ? -6.21286  11.34796 14.70124  1.000 37.09008  ? 587 HOH A O    1 
HETATM 4734 O O    . HOH C 3 .   ? -13.13390 47.24991 15.92645  1.000 36.04757  ? 588 HOH A O    1 
HETATM 4735 O O    . HOH C 3 .   ? -14.94665 13.78729 2.21759   1.000 27.61794  ? 589 HOH A O    1 
HETATM 4736 O O    . HOH C 3 .   ? -3.51742  4.86740  16.31468  1.000 27.86212  ? 590 HOH A O    1 
HETATM 4737 O O    . HOH C 3 .   ? -0.97907  43.07691 18.71163  1.000 27.93456  ? 591 HOH A O    1 
HETATM 4738 O O    . HOH C 3 .   ? 3.96129   32.50511 12.55833  1.000 33.02631  ? 592 HOH A O    1 
HETATM 4739 O O    . HOH C 3 .   ? -20.06235 18.04546 1.41092   1.000 35.85000  ? 593 HOH A O    1 
HETATM 4740 O O    . HOH C 3 .   ? -22.334   50.738   -9.680    1.000 39.43636  ? 594 HOH A O    1 
HETATM 4741 O O    . HOH C 3 .   ? -3.39253  26.31485 -3.03467  1.000 17.61183  ? 595 HOH A O    1 
HETATM 4742 O O    . HOH C 3 .   ? 3.175     20.184   2.760     1.000 20.81993  ? 596 HOH A O    1 
HETATM 4743 O O    . HOH C 3 .   ? -3.87916  6.01643  32.93667  1.000 41.90728  ? 597 HOH A O    1 
HETATM 4744 O O    . HOH C 3 .   ? 10.62199  15.90482 8.90207   1.000 28.82323  ? 598 HOH A O    1 
HETATM 4745 O O    . HOH C 3 .   ? 15.32474  20.24638 14.04855  1.000 51.19104  ? 599 HOH A O    1 
HETATM 4746 O O    . HOH C 3 .   ? -11.24191 27.15863 -6.08061  1.000 24.11541  ? 600 HOH A O    1 
HETATM 4747 O O    . HOH C 3 .   ? -18.35474 22.85132 -10.81189 1.000 48.48551  ? 601 HOH A O    1 
HETATM 4748 O O    . HOH C 3 .   ? -18.92997 37.09067 20.85680  1.000 41.05476  ? 602 HOH A O    1 
HETATM 4749 O O    . HOH C 3 .   ? 3.28635   28.12129 11.25668  1.000 38.58255  ? 603 HOH A O    1 
HETATM 4750 O O    . HOH C 3 .   ? 7.05451   15.35465 35.53893  1.000 44.78176  ? 604 HOH A O    1 
HETATM 4751 O O    . HOH C 3 .   ? 18.61403  8.71759  11.23240  1.000 41.22200  ? 605 HOH A O    1 
HETATM 4752 O O    . HOH C 3 .   ? 1.17375   34.42442 3.27796   1.000 20.97501  ? 606 HOH A O    1 
HETATM 4753 O O    . HOH C 3 .   ? -14.04299 40.65314 -12.23286 1.000 36.17248  ? 607 HOH A O    1 
HETATM 4754 O O    . HOH C 3 .   ? -15.251   37.402   24.809    1.000 26.71248  ? 608 HOH A O    1 
HETATM 4755 O O    . HOH C 3 .   ? -22.63823 31.45983 4.72792   1.000 33.76204  ? 609 HOH A O    1 
HETATM 4756 O O    . HOH C 3 .   ? 4.04270   0.17421  25.16274  1.000 29.12544  ? 610 HOH A O    1 
HETATM 4757 O O    . HOH C 3 .   ? -3.02549  21.72871 20.19249  1.000 23.57874  ? 611 HOH A O    1 
HETATM 4758 O O    . HOH C 3 .   ? -3.71117  2.19565  12.63501  1.000 35.27685  ? 612 HOH A O    1 
HETATM 4759 O O    . HOH C 3 .   ? -10.25574 13.93226 6.50913   1.000 23.73578  ? 613 HOH A O    1 
HETATM 4760 O O    . HOH C 3 .   ? -8.11030  -1.52076 25.17253  1.000 49.43500  ? 614 HOH A O    1 
HETATM 4761 O O    . HOH C 3 .   ? -15.05393 54.35208 -3.99886  1.000 44.38435  ? 615 HOH A O    1 
HETATM 4762 O O    . HOH C 3 .   ? -12.54799 12.61325 6.03407   1.000 31.56662  ? 616 HOH A O    1 
HETATM 4763 O O    . HOH C 3 .   ? -9.33903  34.47996 -8.26659  1.000 26.44256  ? 617 HOH A O    1 
HETATM 4764 O O    . HOH C 3 .   ? -4.38610  15.84453 32.44847  1.000 32.63175  ? 618 HOH A O    1 
HETATM 4765 O O    . HOH C 3 .   ? 16.62987  10.50338 21.83056  1.000 35.98544  ? 619 HOH A O    1 
HETATM 4766 O O    . HOH C 3 .   ? 7.23018   4.61816  7.55904   1.000 35.89046  ? 620 HOH A O    1 
HETATM 4767 O O    . HOH C 3 .   ? -2.18236  15.04534 1.08502   1.000 32.13026  ? 621 HOH A O    1 
HETATM 4768 O O    . HOH C 3 .   ? 1.27608   24.82354 15.07504  1.000 28.12166  ? 622 HOH A O    1 
HETATM 4769 O O    . HOH C 3 .   ? -9.92579  16.42045 -4.50210  1.000 40.81242  ? 623 HOH A O    1 
HETATM 4770 O O    . HOH C 3 .   ? -9.94317  45.65687 -2.71857  1.000 30.44440  ? 624 HOH A O    1 
HETATM 4771 O O    . HOH C 3 .   ? 4.19432   18.84513 6.77457   1.000 29.96213  ? 625 HOH A O    1 
HETATM 4772 O O    . HOH C 3 .   ? -25.60258 42.77285 -11.63205 1.000 32.01161  ? 626 HOH A O    1 
HETATM 4773 O O    . HOH C 3 .   ? -7.00620  27.79762 -4.26460  1.000 17.85852  ? 627 HOH A O    1 
HETATM 4774 O O    . HOH C 3 .   ? -15.07652 30.91781 -1.53613  1.000 17.40320  ? 628 HOH A O    1 
HETATM 4775 O O    . HOH C 3 .   ? 2.67039   21.34849 37.92954  1.000 28.91796  ? 629 HOH A O    1 
HETATM 4776 O O    . HOH C 3 .   ? -24.18885 45.78129 -9.31630  1.000 39.09492  ? 630 HOH A O    1 
HETATM 4777 O O    . HOH C 3 .   ? -9.63173  23.13029 21.96146  1.000 25.92073  ? 631 HOH A O    1 
HETATM 4778 O O    . HOH C 3 .   ? -15.10360 17.19756 11.36636  1.000 31.73568  ? 632 HOH A O    1 
HETATM 4779 O O    . HOH C 3 .   ? -6.17675  12.65023 17.48790  1.000 36.54536  ? 633 HOH A O    1 
HETATM 4780 O O    . HOH C 3 .   ? 2.22910   38.48556 6.50604   1.000 26.42583  ? 634 HOH A O    1 
HETATM 4781 O O    . HOH C 3 .   ? 1.28638   24.45266 3.09734   1.000 19.31075  ? 635 HOH A O    1 
HETATM 4782 O O    . HOH C 3 .   ? -0.63910  30.33234 12.34079  1.000 19.87033  ? 636 HOH A O    1 
HETATM 4783 O O    . HOH C 3 .   ? -7.00925  10.35966 10.26558  1.000 43.90342  ? 637 HOH A O    1 
HETATM 4784 O O    . HOH C 3 .   ? -0.95176  45.73055 12.58034  1.000 36.70366  ? 638 HOH A O    1 
HETATM 4785 O O    . HOH C 3 .   ? -3.43503  40.99525 1.57541   1.000 44.10639  ? 639 HOH A O    1 
HETATM 4786 O O    . HOH C 3 .   ? -22.89216 24.14382 -1.57211  1.000 37.63591  ? 640 HOH A O    1 
HETATM 4787 O O    . HOH C 3 .   ? -5.22376  13.37487 25.88262  1.000 26.25918  ? 641 HOH A O    1 
HETATM 4788 O O    . HOH C 3 .   ? 14.58918  19.84454 27.99810  1.000 43.42618  ? 642 HOH A O    1 
HETATM 4789 O O    . HOH C 3 .   ? -19.27661 42.17640 14.04946  1.000 32.18803  ? 643 HOH A O    1 
HETATM 4790 O O    . HOH C 3 .   ? -10.48442 41.75018 -8.70581  1.000 24.92604  ? 644 HOH A O    1 
HETATM 4791 O O    . HOH C 3 .   ? -21.55530 51.20238 -5.44844  1.000 33.85165  ? 645 HOH A O    1 
HETATM 4792 O O    . HOH C 3 .   ? -0.91084  23.18884 24.27068  1.000 21.69823  ? 646 HOH A O    1 
HETATM 4793 O O    . HOH C 3 .   ? 5.14665   35.90768 15.09481  1.000 38.76156  ? 647 HOH A O    1 
HETATM 4794 O O    . HOH C 3 .   ? -21.05116 32.13090 -13.31402 1.000 42.98813  ? 648 HOH A O    1 
HETATM 4795 O O    . HOH C 3 .   ? -8.83936  26.01100 -5.39436  1.000 22.27660  ? 649 HOH A O    1 
HETATM 4796 O O    . HOH C 3 .   ? -15.00384 50.64652 -6.69766  1.000 40.47267  ? 650 HOH A O    1 
HETATM 4797 O O    . HOH C 3 .   ? -25.58931 37.89116 -4.98525  1.000 49.43030  ? 651 HOH A O    1 
HETATM 4798 O O    . HOH C 3 .   ? -13.28212 18.55757 -7.52729  1.000 35.96866  ? 652 HOH A O    1 
HETATM 4799 O O    . HOH C 3 .   ? -14.09360 31.15245 -11.49425 1.000 37.13495  ? 653 HOH A O    1 
HETATM 4800 O O    . HOH C 3 .   ? -14.28783 27.27935 -8.12099  1.000 32.09781  ? 654 HOH A O    1 
HETATM 4801 O O    . HOH C 3 .   ? 17.52561  2.78004  11.50114  1.000 41.66364  ? 655 HOH A O    1 
HETATM 4802 O O    . HOH C 3 .   ? -17.545   15.621   -9.527    1.000 43.41324  ? 656 HOH A O    1 
HETATM 4803 O O    . HOH C 3 .   ? 1.01019   4.80790  34.80295  1.000 29.23776  ? 657 HOH A O    1 
HETATM 4804 O O    . HOH C 3 .   ? -1.24352  47.19685 10.58842  1.000 49.65267  ? 658 HOH A O    1 
HETATM 4805 O O    . HOH C 3 .   ? 5.53458   12.18131 11.82668  1.000 24.76861  ? 659 HOH A O    1 
HETATM 4806 O O    . HOH C 3 .   ? 12.42214  7.70021  33.15955  1.000 46.33249  ? 660 HOH A O    1 
HETATM 4807 O O    . HOH C 3 .   ? 0.00000   23.11456 0.00000   0.50  19.49882  ? 661 HOH A O    1 
HETATM 4808 O O    . HOH C 3 .   ? -6.39477  36.29070 -8.10753  1.000 30.83129  ? 662 HOH A O    1 
HETATM 4809 O O    . HOH C 3 .   ? 15.16220  14.60620 8.53862   1.000 28.25451  ? 663 HOH A O    1 
HETATM 4810 O O    . HOH C 3 .   ? -10.03735 55.22075 9.75021   1.000 41.45083  ? 664 HOH A O    1 
HETATM 4811 O O    . HOH C 3 .   ? 4.70013   26.10460 5.32613   1.000 27.61562  ? 665 HOH A O    1 
HETATM 4812 O O    . HOH C 3 .   ? -6.96923  -0.77514 22.98764  1.000 43.79274  ? 666 HOH A O    1 
HETATM 4813 O O    . HOH C 3 .   ? -18.07249 49.78286 -7.19455  1.000 37.50298  ? 667 HOH A O    1 
HETATM 4814 O O    . HOH C 3 .   ? 4.02013   41.39146 11.67516  1.000 36.58345  ? 668 HOH A O    1 
HETATM 4815 O O    . HOH C 3 .   ? 16.72931  8.12515  20.43955  1.000 31.18266  ? 669 HOH A O    1 
HETATM 4816 O O    . HOH C 3 .   ? -13.28021 48.50939 -6.65417  1.000 30.45104  ? 670 HOH A O    1 
HETATM 4817 O O    . HOH C 3 .   ? -5.40066  4.76911  18.44551  1.000 31.24863  ? 671 HOH A O    1 
HETATM 4818 O O    . HOH C 3 .   ? -12.09880 14.82540 -4.83359  1.000 35.59372  ? 672 HOH A O    1 
HETATM 4819 O O    . HOH C 3 .   ? 18.16661  3.84430  14.21907  1.000 34.65214  ? 673 HOH A O    1 
HETATM 4820 O O    . HOH C 3 .   ? -26.40879 32.76374 4.12158   1.000 43.53388  ? 674 HOH A O    1 
HETATM 4821 O O    . HOH C 3 .   ? -5.07963  44.64063 5.69401   1.000 31.53984  ? 675 HOH A O    1 
HETATM 4822 O O    . HOH C 3 .   ? -3.61141  0.73901  19.11403  1.000 47.98495  ? 676 HOH A O    1 
HETATM 4823 O O    . HOH C 3 .   ? -25.51566 23.67981 9.19800   1.000 34.08888  ? 677 HOH A O    1 
HETATM 4824 O O    . HOH C 3 .   ? -3.31802  22.53105 22.85701  1.000 22.96572  ? 678 HOH A O    1 
HETATM 4825 O O    . HOH C 3 .   ? 5.032     26.513   8.070     1.000 41.41061  ? 679 HOH A O    1 
HETATM 4826 O O    . HOH C 3 .   ? 3.69772   33.67453 23.26219  1.000 43.31875  ? 680 HOH A O    1 
HETATM 4827 O O    . HOH C 3 .   ? -5.99139  30.93365 -7.76074  1.000 40.50853  ? 681 HOH A O    1 
HETATM 4828 O O    . HOH C 3 .   ? 1.29406   33.29242 22.92305  1.000 42.39551  ? 682 HOH A O    1 
HETATM 4829 O O    . HOH C 3 .   ? -11.77326 26.88675 -8.83937  1.000 36.44837  ? 683 HOH A O    1 
HETATM 4830 O O    . HOH C 3 .   ? -6.03265  16.03709 26.57715  1.000 42.74213  ? 684 HOH A O    1 
HETATM 4831 O O    . HOH C 3 .   ? 6.28515   21.61601 17.10129  1.000 28.19175  ? 685 HOH A O    1 
HETATM 4832 O O    . HOH C 3 .   ? -0.79940  -0.99440 34.20244  1.000 48.70255  ? 686 HOH A O    1 
HETATM 4833 O O    . HOH C 3 .   ? 1.01242   44.01969 11.61933  1.000 29.14482  ? 687 HOH A O    1 
HETATM 4834 O O    . HOH C 3 .   ? -4.114    36.307   -7.154    1.000 32.12539  ? 688 HOH A O    1 
HETATM 4835 O O    . HOH C 3 .   ? 19.18143  11.15651 17.39408  1.000 45.60512  ? 689 HOH A O    1 
HETATM 4836 O O    . HOH C 3 .   ? -10.72354 8.08228  23.60815  0.50  22.39770  ? 690 HOH A O    1 
HETATM 4837 O O    . HOH C 3 .   ? -3.51608  37.51146 23.04470  1.000 43.12074  ? 691 HOH A O    1 
HETATM 4838 O O    . HOH C 3 .   ? -4.96283  3.35297  32.73153  1.000 39.46439  ? 692 HOH A O    1 
HETATM 4839 O O    . HOH C 3 .   ? -25.60556 33.39650 8.95259   1.000 41.43247  ? 693 HOH A O    1 
HETATM 4840 O O    . HOH C 3 .   ? -21.60559 33.96411 -15.82191 1.000 46.35841  ? 694 HOH A O    1 
HETATM 4841 O O    . HOH C 3 .   ? -10.72354 25.40123 23.60815  0.50  25.96396  ? 695 HOH A O    1 
HETATM 4842 O O    . HOH C 3 .   ? -2.31561  22.34683 -1.35131  1.000 19.20161  ? 696 HOH A O    1 
HETATM 4843 O O    . HOH C 3 .   ? 1.97691   28.16247 17.85491  1.000 34.28230  ? 697 HOH A O    1 
HETATM 4844 O O    . HOH C 3 .   ? -18.55654 56.68782 7.56422   1.000 59.01210  ? 698 HOH A O    1 
HETATM 4845 O O    . HOH C 3 .   ? -7.77460  22.58148 -6.20351  1.000 33.63921  ? 699 HOH A O    1 
HETATM 4846 O O    . HOH C 3 .   ? -24.48638 49.61275 0.79840   1.000 53.64248  ? 700 HOH A O    1 
HETATM 4847 O O    . HOH C 3 .   ? -5.64662  9.74072  12.31327  1.000 43.92594  ? 701 HOH A O    1 
HETATM 4848 O O    . HOH C 3 .   ? -20.63588 48.16150 18.01345  1.000 48.72309  ? 702 HOH A O    1 
HETATM 4849 O O    . HOH C 3 .   ? -10.85020 8.65816  0.03077   1.000 51.99530  ? 703 HOH A O    1 
HETATM 4850 O O    . HOH C 3 .   ? -0.74540  32.52528 3.39462   1.000 32.25118  ? 704 HOH A O    1 
HETATM 4851 O O    . HOH C 3 .   ? -12.87149 43.67934 -8.87201  1.000 45.69434  ? 705 HOH A O    1 
HETATM 4852 O O    . HOH C 3 .   ? 0.99134   43.61866 9.35519   1.000 51.22884  ? 706 HOH A O    1 
HETATM 4853 O O    . HOH C 3 .   ? -28.52739 33.13080 11.92893  1.000 50.90110  ? 707 HOH A O    1 
HETATM 4854 O O    . HOH C 3 .   ? -24.51403 37.44361 -12.26072 1.000 35.35985  ? 708 HOH A O    1 
HETATM 4855 O O    . HOH C 3 .   ? -10.09580 22.51397 -10.65881 1.000 47.19132  ? 709 HOH A O    1 
HETATM 4856 O O    . HOH C 3 .   ? -19.584   18.883   -10.933   1.000 45.96728  ? 710 HOH A O    1 
HETATM 4857 O O    . HOH C 3 .   ? -21.60435 42.02314 13.75208  1.000 53.11909  ? 711 HOH A O    1 
HETATM 4858 O O    . HOH C 3 .   ? -20.611   33.066   22.608    1.000 49.07788  ? 712 HOH A O    1 
HETATM 4859 O O    . HOH C 3 .   ? -13.42926 47.11299 -8.90257  1.000 48.30077  ? 713 HOH A O    1 
HETATM 4860 O O    . HOH C 3 .   ? 12.63975  3.73244  7.22590   1.000 52.23083  ? 714 HOH A O    1 
HETATM 4861 O O    . HOH C 3 .   ? 7.92374   18.24173 11.92239  1.000 34.59839  ? 715 HOH A O    1 
HETATM 4862 O O    . HOH C 3 .   ? -8.95534  43.42039 20.68464  1.000 38.44269  ? 716 HOH A O    1 
HETATM 4863 O O    . HOH C 3 .   ? -15.32012 44.61461 16.29979  1.000 62.22769  ? 717 HOH A O    1 
HETATM 4864 O O    . HOH C 3 .   ? 10.76735  -2.84419 19.38977  1.000 51.20483  ? 718 HOH A O    1 
HETATM 4865 O O    . HOH C 3 .   ? -10.05612 47.99522 -3.90900  1.000 46.88786  ? 719 HOH A O    1 
HETATM 4866 O O    . HOH C 3 .   ? 6.16788   21.36058 10.00298  1.000 37.51506  ? 720 HOH A O    1 
HETATM 4867 O O    . HOH C 3 .   ? -25.88871 31.89013 10.94017  1.000 47.93221  ? 721 HOH A O    1 
HETATM 4868 O O    . HOH C 3 .   ? -21.63154 11.59242 6.88308   1.000 55.32781  ? 722 HOH A O    1 
HETATM 4869 O O    . HOH C 3 .   ? -21.56804 14.14208 7.53634   1.000 45.77471  ? 723 HOH A O    1 
HETATM 4870 O O    . HOH C 3 .   ? -13.50185 28.90041 -10.51904 1.000 45.82082  ? 724 HOH A O    1 
HETATM 4871 O O    . HOH C 3 .   ? 1.41418   13.28548 3.15099   1.000 49.92635  ? 725 HOH A O    1 
HETATM 4872 O O    . HOH C 3 .   ? -11.62952 10.56095 4.13087   1.000 48.92691  ? 726 HOH A O    1 
HETATM 4873 O O    . HOH C 3 .   ? -8.14594  20.46973 -7.60479  1.000 39.31743  ? 727 HOH A O    1 
HETATM 4874 O O    . HOH C 3 .   ? -9.48040  25.19584 -9.97872  1.000 48.11370  ? 728 HOH A O    1 
HETATM 4875 O O    . HOH C 3 .   ? 12.90102  16.01529 7.29058   1.000 31.42217  ? 729 HOH A O    1 
HETATM 4876 O O    . HOH C 3 .   ? -10.65269 48.78008 -6.19072  1.000 49.19927  ? 730 HOH A O    1 
HETATM 4877 O O    . HOH C 3 .   ? -14.38216 43.18665 -10.99275 1.000 32.74060  ? 731 HOH A O    1 
HETATM 4878 O O    . HOH C 3 .   ? -7.98119  53.75188 13.88295  1.000 49.83949  ? 732 HOH A O    1 
HETATM 4879 O O    . HOH C 3 .   ? 3.57867   40.44013 7.69641   1.000 44.89196  ? 733 HOH A O    1 
HETATM 4880 O O    . HOH C 3 .   ? -8.57448  8.99199  33.01954  1.000 42.63742  ? 734 HOH A O    1 
HETATM 4881 O O    . HOH C 3 .   ? -11.15294 1.40565  27.46298  1.000 47.91465  ? 735 HOH A O    1 
HETATM 4882 O O    . HOH C 3 .   ? 6.79501   18.73219 14.57875  1.000 37.67252  ? 736 HOH A O    1 
HETATM 4883 O O    . HOH C 3 .   ? 4.52199   17.07048 11.38056  1.000 32.11624  ? 737 HOH A O    1 
HETATM 4884 O O    . HOH C 3 .   ? -4.21961  0.03007  10.78806  1.000 52.52620  ? 738 HOH A O    1 
HETATM 4885 O O    . HOH C 3 .   ? 2.13036   30.23844 12.79100  1.000 38.61884  ? 739 HOH A O    1 
HETATM 4886 O O    . HOH C 3 .   ? -6.97626  53.85202 6.56387   1.000 47.86394  ? 740 HOH A O    1 
HETATM 4887 O O    . HOH C 3 .   ? 8.47657   15.83089 7.01103   1.000 40.10195  ? 741 HOH A O    1 
HETATM 4888 O O    . HOH C 3 .   ? 9.16413   23.22303 20.93237  1.000 46.47214  ? 742 HOH A O    1 
HETATM 4889 O O    . HOH C 3 .   ? -7.72738  15.98962 31.75775  1.000 45.68331  ? 743 HOH A O    1 
HETATM 4890 O O    . HOH C 3 .   ? 8.75073   22.93144 17.98760  1.000 48.53058  ? 744 HOH A O    1 
HETATM 4891 O O    . HOH C 3 .   ? 6.62064   27.92493 28.63865  1.000 58.98476  ? 745 HOH A O    1 
HETATM 4892 O O    . HOH C 3 .   ? 1.02364   -3.70564 25.49735  1.000 53.00934  ? 746 HOH A O    1 
HETATM 4893 O O    . HOH C 3 .   ? -19.844   14.943   -10.186   1.000 44.43134  ? 747 HOH A O    1 
HETATM 4894 O O    . HOH C 3 .   ? 9.835     38.341   11.053    1.000 54.76108  ? 748 HOH A O    1 
HETATM 4895 O O    . HOH C 3 .   ? -16.31450 11.49142 0.88411   1.000 48.01830  ? 749 HOH A O    1 
HETATM 4896 O O    . HOH C 3 .   ? 6.635     18.796   7.795     1.000 41.76430  ? 750 HOH A O    1 
HETATM 4897 O O    . HOH C 3 .   ? -13.27188 11.35122 8.30251   1.000 40.54196  ? 751 HOH A O    1 
HETATM 4898 O O    . HOH C 3 .   ? -12.18489 54.16951 14.56829  1.000 49.50633  ? 752 HOH A O    1 
HETATM 4899 O O    . HOH C 3 .   ? -3.79075  15.92037 -0.86163  1.000 34.29963  ? 753 HOH A O    1 
HETATM 4900 O O    . HOH C 3 .   ? 2.35710   -1.46959 26.53607  1.000 46.83098  ? 754 HOH A O    1 
HETATM 4901 O O    . HOH C 3 .   ? -7.50988  46.01812 -1.18762  1.000 38.75028  ? 755 HOH A O    1 
HETATM 4902 O O    . HOH C 3 .   ? 18.60047  6.08963  14.00152  1.000 35.41453  ? 756 HOH A O    1 
HETATM 4903 O O    . HOH C 3 .   ? -5.34336  2.43379  19.68468  1.000 46.01225  ? 757 HOH A O    1 
HETATM 4904 O O    . HOH C 3 .   ? 19.46514  2.80204  16.27919  1.000 47.16910  ? 758 HOH A O    1 
HETATM 4905 O O    . HOH C 3 .   ? 0.00000   15.37964 0.00000   0.50  33.59915  ? 759 HOH A O    1 
HETATM 4906 O O    . HOH C 3 .   ? -7.66652  24.84115 -7.77999  1.000 38.76240  ? 760 HOH A O    1 
HETATM 4907 O O    . HOH C 3 .   ? 3.771     16.661   5.341     1.000 27.93457  ? 761 HOH A O    1 
HETATM 4908 O O    . HOH C 3 .   ? 0.17472   41.12484 3.70049   1.000 45.24216  ? 762 HOH A O    1 
HETATM 4909 O O    . HOH C 3 .   ? 9.45164   4.84424  5.85397   1.000 41.36024  ? 763 HOH A O    1 
HETATM 4910 O O    . HOH C 3 .   ? 2.647     17.442   2.907     1.000 24.63419  ? 764 HOH A O    1 
HETATM 4911 O O    . HOH C 3 .   ? 5.541     14.973   5.054     1.000 38.81757  ? 765 HOH A O    1 
HETATM 4912 O O    . HOH C 3 .   ? -26.42762 40.50716 -11.73052 1.000 45.99978  ? 766 HOH A O    1 
HETATM 4913 O O    . HOH C 3 .   ? 18.59827  6.30304  21.14151  1.000 42.26517  ? 767 HOH A O    1 
HETATM 4914 O O    . HOH C 3 .   ? -11.63389 39.97007 -10.57336 1.000 37.12353  ? 768 HOH A O    1 
HETATM 4915 O O    . HOH C 3 .   ? -14.16989 52.08978 14.27361  1.000 42.42089  ? 769 HOH A O    1 
HETATM 4916 O O    . HOH C 3 .   ? 18.03020  8.60175  17.79582  1.000 36.16055  ? 770 HOH A O    1 
HETATM 4917 O O    . HOH C 3 .   ? -10.72354 18.68805 23.60815  0.50  28.56668  ? 771 HOH A O    1 
HETATM 4918 O O    . HOH C 3 .   ? -3.76460  2.10797  15.16990  1.000 34.11043  ? 772 HOH A O    1 
HETATM 4919 O O    . HOH C 3 .   ? -18.00488 10.90731 -1.29625  1.000 47.05590  ? 773 HOH A O    1 
HETATM 4920 O O    . HOH C 3 .   ? -20.66547 11.04123 -0.57207  1.000 48.41833  ? 774 HOH A O    1 
# 
