data_9BO7
# 
_entry.id   9BO7 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BO7         pdb_00009bo7 10.2210/pdb9bo7/pdb 
WWPDB D_1000282937 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-02-12 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BO7 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-03 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              karen.anderson@yale.edu 
_pdbx_contact_author.name_first         Karen 
_pdbx_contact_author.name_last          Anderson 
_pdbx_contact_author.name_mi            S 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-3433-0780 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Papini, C.'     1 0000-0002-6098-4959 
'Kenneson, J.'   2 ?                   
'Anderson, K.S.' 3 0000-0003-3433-0780 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Acs Bio Med Chem Au' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2694-2437 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Exploring Possible Drug-Resistant Variants of SARS-CoV-2 Main Protease (Mpro) with Noncovalent Preclinical Candidate, Mpro61' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acsbiomedchemau.4c00109 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Kenneson, J.R.'  1 ? 
primary 'Papini, C.'      2 ? 
primary 'Tang, S.'        3 ? 
primary 'Huynh, K.'       4 ? 
primary 'Zhang, C.H.'     5 ? 
primary 'Jorgensen, W.L.' 6 ? 
primary 'Anderson, K.S.'  7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '3C-like proteinase nsp5' 33859.562 1   3.4.22.69 ? ? ? 
2 non-polymer syn 
;(1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide
;
501.542   1   ?         ? ? ? 
3 water       nat water 18.015    314 ?         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMFNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMFNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 
;(1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide
;
4WI 
3 water HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   GLY n 
1 3   PHE n 
1 4   ARG n 
1 5   LYS n 
1 6   MET n 
1 7   ALA n 
1 8   PHE n 
1 9   PRO n 
1 10  SER n 
1 11  GLY n 
1 12  LYS n 
1 13  VAL n 
1 14  GLU n 
1 15  GLY n 
1 16  CYS n 
1 17  MET n 
1 18  VAL n 
1 19  GLN n 
1 20  VAL n 
1 21  THR n 
1 22  CYS n 
1 23  GLY n 
1 24  THR n 
1 25  THR n 
1 26  THR n 
1 27  LEU n 
1 28  ASN n 
1 29  GLY n 
1 30  LEU n 
1 31  TRP n 
1 32  LEU n 
1 33  ASP n 
1 34  ASP n 
1 35  VAL n 
1 36  VAL n 
1 37  TYR n 
1 38  CYS n 
1 39  PRO n 
1 40  ARG n 
1 41  HIS n 
1 42  VAL n 
1 43  ILE n 
1 44  CYS n 
1 45  THR n 
1 46  SER n 
1 47  GLU n 
1 48  ASP n 
1 49  MET n 
1 50  PHE n 
1 51  ASN n 
1 52  PRO n 
1 53  ASN n 
1 54  TYR n 
1 55  GLU n 
1 56  ASP n 
1 57  LEU n 
1 58  LEU n 
1 59  ILE n 
1 60  ARG n 
1 61  LYS n 
1 62  SER n 
1 63  ASN n 
1 64  HIS n 
1 65  ASN n 
1 66  PHE n 
1 67  LEU n 
1 68  VAL n 
1 69  GLN n 
1 70  ALA n 
1 71  GLY n 
1 72  ASN n 
1 73  VAL n 
1 74  GLN n 
1 75  LEU n 
1 76  ARG n 
1 77  VAL n 
1 78  ILE n 
1 79  GLY n 
1 80  HIS n 
1 81  SER n 
1 82  MET n 
1 83  GLN n 
1 84  ASN n 
1 85  CYS n 
1 86  VAL n 
1 87  LEU n 
1 88  LYS n 
1 89  LEU n 
1 90  LYS n 
1 91  VAL n 
1 92  ASP n 
1 93  THR n 
1 94  ALA n 
1 95  ASN n 
1 96  PRO n 
1 97  LYS n 
1 98  THR n 
1 99  PRO n 
1 100 LYS n 
1 101 TYR n 
1 102 LYS n 
1 103 PHE n 
1 104 VAL n 
1 105 ARG n 
1 106 ILE n 
1 107 GLN n 
1 108 PRO n 
1 109 GLY n 
1 110 GLN n 
1 111 THR n 
1 112 PHE n 
1 113 SER n 
1 114 VAL n 
1 115 LEU n 
1 116 ALA n 
1 117 CYS n 
1 118 TYR n 
1 119 ASN n 
1 120 GLY n 
1 121 SER n 
1 122 PRO n 
1 123 SER n 
1 124 GLY n 
1 125 VAL n 
1 126 TYR n 
1 127 GLN n 
1 128 CYS n 
1 129 ALA n 
1 130 MET n 
1 131 ARG n 
1 132 PRO n 
1 133 ASN n 
1 134 PHE n 
1 135 THR n 
1 136 ILE n 
1 137 LYS n 
1 138 GLY n 
1 139 SER n 
1 140 PHE n 
1 141 LEU n 
1 142 ASN n 
1 143 GLY n 
1 144 SER n 
1 145 CYS n 
1 146 GLY n 
1 147 SER n 
1 148 VAL n 
1 149 GLY n 
1 150 PHE n 
1 151 ASN n 
1 152 ILE n 
1 153 ASP n 
1 154 TYR n 
1 155 ASP n 
1 156 CYS n 
1 157 VAL n 
1 158 SER n 
1 159 PHE n 
1 160 CYS n 
1 161 TYR n 
1 162 MET n 
1 163 HIS n 
1 164 HIS n 
1 165 MET n 
1 166 GLU n 
1 167 LEU n 
1 168 PRO n 
1 169 THR n 
1 170 GLY n 
1 171 VAL n 
1 172 HIS n 
1 173 ALA n 
1 174 GLY n 
1 175 THR n 
1 176 ASP n 
1 177 LEU n 
1 178 GLU n 
1 179 GLY n 
1 180 ASN n 
1 181 PHE n 
1 182 TYR n 
1 183 GLY n 
1 184 PRO n 
1 185 PHE n 
1 186 VAL n 
1 187 ASP n 
1 188 ARG n 
1 189 GLN n 
1 190 THR n 
1 191 ALA n 
1 192 GLN n 
1 193 ALA n 
1 194 ALA n 
1 195 GLY n 
1 196 THR n 
1 197 ASP n 
1 198 THR n 
1 199 THR n 
1 200 ILE n 
1 201 THR n 
1 202 VAL n 
1 203 ASN n 
1 204 VAL n 
1 205 LEU n 
1 206 ALA n 
1 207 TRP n 
1 208 LEU n 
1 209 TYR n 
1 210 ALA n 
1 211 ALA n 
1 212 VAL n 
1 213 ILE n 
1 214 ASN n 
1 215 GLY n 
1 216 ASP n 
1 217 ARG n 
1 218 TRP n 
1 219 PHE n 
1 220 LEU n 
1 221 ASN n 
1 222 ARG n 
1 223 PHE n 
1 224 THR n 
1 225 THR n 
1 226 THR n 
1 227 LEU n 
1 228 ASN n 
1 229 ASP n 
1 230 PHE n 
1 231 ASN n 
1 232 LEU n 
1 233 VAL n 
1 234 ALA n 
1 235 MET n 
1 236 LYS n 
1 237 TYR n 
1 238 ASN n 
1 239 TYR n 
1 240 GLU n 
1 241 PRO n 
1 242 LEU n 
1 243 THR n 
1 244 GLN n 
1 245 ASP n 
1 246 HIS n 
1 247 VAL n 
1 248 ASP n 
1 249 ILE n 
1 250 LEU n 
1 251 GLY n 
1 252 PRO n 
1 253 LEU n 
1 254 SER n 
1 255 ALA n 
1 256 GLN n 
1 257 THR n 
1 258 GLY n 
1 259 ILE n 
1 260 ALA n 
1 261 VAL n 
1 262 LEU n 
1 263 ASP n 
1 264 MET n 
1 265 CYS n 
1 266 ALA n 
1 267 SER n 
1 268 LEU n 
1 269 LYS n 
1 270 GLU n 
1 271 LEU n 
1 272 LEU n 
1 273 GLN n 
1 274 ASN n 
1 275 GLY n 
1 276 MET n 
1 277 ASN n 
1 278 GLY n 
1 279 ARG n 
1 280 THR n 
1 281 ILE n 
1 282 LEU n 
1 283 GLY n 
1 284 SER n 
1 285 ALA n 
1 286 LEU n 
1 287 LEU n 
1 288 GLU n 
1 289 ASP n 
1 290 GLU n 
1 291 PHE n 
1 292 THR n 
1 293 PRO n 
1 294 PHE n 
1 295 ASP n 
1 296 VAL n 
1 297 VAL n 
1 298 ARG n 
1 299 GLN n 
1 300 CYS n 
1 301 SER n 
1 302 GLY n 
1 303 VAL n 
1 304 THR n 
1 305 PHE n 
1 306 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   306 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'rep, 1a-1b' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
4WI non-polymer         . 
;(1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide
;
'PF-07321332, bound form; nirmatrelvir, bound form; Paxlovid, bound form' 'C23 H34 F3 N5 O4' 501.542 
ALA 'L-peptide linking' y ALANINE ?                                                                         'C3 H7 N O2'       
89.093  
ARG 'L-peptide linking' y ARGININE ?                                                                         'C6 H15 N4 O2 1'   
175.209 
ASN 'L-peptide linking' y ASPARAGINE ?                                                                         'C4 H8 N2 O3'      
132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                                                                         'C4 H7 N O4' 
133.103 
CYS 'L-peptide linking' y CYSTEINE ?                                                                         'C3 H7 N O2 S'     
121.158 
GLN 'L-peptide linking' y GLUTAMINE ?                                                                         'C5 H10 N2 O3'     
146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                                                                         'C5 H9 N O4' 
147.129 
GLY 'peptide linking'   y GLYCINE ?                                                                         'C2 H5 N O2'       
75.067  
HIS 'L-peptide linking' y HISTIDINE ?                                                                         'C6 H10 N3 O2 1'   
156.162 
HOH non-polymer         . WATER ?                                                                         'H2 O'             
18.015  
ILE 'L-peptide linking' y ISOLEUCINE ?                                                                         'C6 H13 N O2'      
131.173 
LEU 'L-peptide linking' y LEUCINE ?                                                                         'C6 H13 N O2'      
131.173 
LYS 'L-peptide linking' y LYSINE ?                                                                         'C6 H15 N2 O2 1'   
147.195 
MET 'L-peptide linking' y METHIONINE ?                                                                         'C5 H11 N O2 S'    
149.211 
PHE 'L-peptide linking' y PHENYLALANINE ?                                                                         'C9 H11 N O2' 
165.189 
PRO 'L-peptide linking' y PROLINE ?                                                                         'C5 H9 N O2'       
115.130 
SER 'L-peptide linking' y SERINE ?                                                                         'C3 H7 N O3'       
105.093 
THR 'L-peptide linking' y THREONINE ?                                                                         'C4 H9 N O3'       
119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ?                                                                         'C11 H12 N2 O2'    
204.225 
TYR 'L-peptide linking' y TYROSINE ?                                                                         'C9 H11 N O3'      
181.189 
VAL 'L-peptide linking' y VALINE ?                                                                         'C5 H11 N O2'      
117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   1   1   SER SER A . n 
A 1 2   GLY 2   2   2   GLY GLY A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   ARG 4   4   4   ARG ARG A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   MET 6   6   6   MET MET A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   PRO 9   9   9   PRO PRO A . n 
A 1 10  SER 10  10  10  SER SER A . n 
A 1 11  GLY 11  11  11  GLY GLY A . n 
A 1 12  LYS 12  12  12  LYS LYS A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  GLY 15  15  15  GLY GLY A . n 
A 1 16  CYS 16  16  16  CYS CYS A . n 
A 1 17  MET 17  17  17  MET MET A . n 
A 1 18  VAL 18  18  18  VAL VAL A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  THR 21  21  21  THR THR A . n 
A 1 22  CYS 22  22  22  CYS CYS A . n 
A 1 23  GLY 23  23  23  GLY GLY A . n 
A 1 24  THR 24  24  24  THR THR A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  THR 26  26  26  THR THR A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  ASN 28  28  28  ASN ASN A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  TRP 31  31  31  TRP TRP A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  ASP 33  33  33  ASP ASP A . n 
A 1 34  ASP 34  34  34  ASP ASP A . n 
A 1 35  VAL 35  35  35  VAL VAL A . n 
A 1 36  VAL 36  36  36  VAL VAL A . n 
A 1 37  TYR 37  37  37  TYR TYR A . n 
A 1 38  CYS 38  38  38  CYS CYS A . n 
A 1 39  PRO 39  39  39  PRO PRO A . n 
A 1 40  ARG 40  40  40  ARG ARG A . n 
A 1 41  HIS 41  41  41  HIS HIS A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  ILE 43  43  43  ILE ILE A . n 
A 1 44  CYS 44  44  44  CYS CYS A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  SER 46  46  46  SER SER A . n 
A 1 47  GLU 47  47  47  GLU GLU A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  MET 49  49  49  MET MET A . n 
A 1 50  PHE 50  50  50  PHE PHE A . n 
A 1 51  ASN 51  51  51  ASN ASN A . n 
A 1 52  PRO 52  52  52  PRO PRO A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  TYR 54  54  54  TYR TYR A . n 
A 1 55  GLU 55  55  55  GLU GLU A . n 
A 1 56  ASP 56  56  56  ASP ASP A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  ILE 59  59  59  ILE ILE A . n 
A 1 60  ARG 60  60  60  ARG ARG A . n 
A 1 61  LYS 61  61  61  LYS LYS A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  ASN 63  63  63  ASN ASN A . n 
A 1 64  HIS 64  64  64  HIS HIS A . n 
A 1 65  ASN 65  65  65  ASN ASN A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  GLN 69  69  69  GLN GLN A . n 
A 1 70  ALA 70  70  70  ALA ALA A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  ASN 72  72  72  ASN ASN A . n 
A 1 73  VAL 73  73  73  VAL VAL A . n 
A 1 74  GLN 74  74  74  GLN GLN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  ARG 76  76  76  ARG ARG A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  GLY 79  79  79  GLY GLY A . n 
A 1 80  HIS 80  80  80  HIS HIS A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  MET 82  82  82  MET MET A . n 
A 1 83  GLN 83  83  83  GLN GLN A . n 
A 1 84  ASN 84  84  84  ASN ASN A . n 
A 1 85  CYS 85  85  85  CYS CYS A . n 
A 1 86  VAL 86  86  86  VAL VAL A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  LYS 88  88  88  LYS LYS A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  LYS 90  90  90  LYS LYS A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  ASP 92  92  92  ASP ASP A . n 
A 1 93  THR 93  93  93  THR THR A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  PRO 96  96  96  PRO PRO A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  PRO 99  99  99  PRO PRO A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 TYR 101 101 101 TYR TYR A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 PHE 103 103 103 PHE PHE A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 ARG 105 105 105 ARG ARG A . n 
A 1 106 ILE 106 106 106 ILE ILE A . n 
A 1 107 GLN 107 107 107 GLN GLN A . n 
A 1 108 PRO 108 108 108 PRO PRO A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 GLN 110 110 110 GLN GLN A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 PHE 112 112 112 PHE PHE A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 CYS 117 117 117 CYS CYS A . n 
A 1 118 TYR 118 118 118 TYR TYR A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 SER 123 123 123 SER SER A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 MET 130 130 130 MET MET A . n 
A 1 131 ARG 131 131 131 ARG ARG A . n 
A 1 132 PRO 132 132 132 PRO PRO A . n 
A 1 133 ASN 133 133 133 ASN ASN A . n 
A 1 134 PHE 134 134 134 PHE PHE A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 LYS 137 137 137 LYS LYS A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 PHE 140 140 140 PHE PHE A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 ASN 142 142 142 ASN ASN A . n 
A 1 143 GLY 143 143 143 GLY GLY A . n 
A 1 144 SER 144 144 144 SER SER A . n 
A 1 145 CYS 145 145 145 CYS CYS A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 GLY 149 149 149 GLY GLY A . n 
A 1 150 PHE 150 150 150 PHE PHE A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 ILE 152 152 152 ILE ILE A . n 
A 1 153 ASP 153 153 153 ASP ASP A . n 
A 1 154 TYR 154 154 154 TYR TYR A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 CYS 156 156 156 CYS CYS A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 SER 158 158 158 SER SER A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 CYS 160 160 160 CYS CYS A . n 
A 1 161 TYR 161 161 161 TYR TYR A . n 
A 1 162 MET 162 162 162 MET MET A . n 
A 1 163 HIS 163 163 163 HIS HIS A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 MET 165 165 165 MET MET A . n 
A 1 166 GLU 166 166 166 GLU GLU A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 PRO 168 168 168 PRO PRO A . n 
A 1 169 THR 169 169 169 THR THR A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 VAL 171 171 171 VAL VAL A . n 
A 1 172 HIS 172 172 172 HIS HIS A . n 
A 1 173 ALA 173 173 173 ALA ALA A . n 
A 1 174 GLY 174 174 174 GLY GLY A . n 
A 1 175 THR 175 175 175 THR THR A . n 
A 1 176 ASP 176 176 176 ASP ASP A . n 
A 1 177 LEU 177 177 177 LEU LEU A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 TYR 182 182 182 TYR TYR A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 VAL 186 186 186 VAL VAL A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 GLN 189 189 189 GLN GLN A . n 
A 1 190 THR 190 190 190 THR THR A . n 
A 1 191 ALA 191 191 191 ALA ALA A . n 
A 1 192 GLN 192 192 192 GLN GLN A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 THR 196 196 196 THR THR A . n 
A 1 197 ASP 197 197 197 ASP ASP A . n 
A 1 198 THR 198 198 198 THR THR A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 ILE 200 200 200 ILE ILE A . n 
A 1 201 THR 201 201 201 THR THR A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 ALA 206 206 206 ALA ALA A . n 
A 1 207 TRP 207 207 207 TRP TRP A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ALA 210 210 210 ALA ALA A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ASN 214 214 214 ASN ASN A . n 
A 1 215 GLY 215 215 215 GLY GLY A . n 
A 1 216 ASP 216 216 216 ASP ASP A . n 
A 1 217 ARG 217 217 217 ARG ARG A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 ASN 221 221 221 ASN ASN A . n 
A 1 222 ARG 222 222 222 ARG ARG A . n 
A 1 223 PHE 223 223 223 PHE PHE A . n 
A 1 224 THR 224 224 224 THR THR A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 THR 226 226 226 THR THR A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 ASN 228 228 228 ASN ASN A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 PHE 230 230 230 PHE PHE A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 VAL 233 233 233 VAL VAL A . n 
A 1 234 ALA 234 234 234 ALA ALA A . n 
A 1 235 MET 235 235 235 MET MET A . n 
A 1 236 LYS 236 236 236 LYS LYS A . n 
A 1 237 TYR 237 237 237 TYR TYR A . n 
A 1 238 ASN 238 238 238 ASN ASN A . n 
A 1 239 TYR 239 239 239 TYR TYR A . n 
A 1 240 GLU 240 240 240 GLU GLU A . n 
A 1 241 PRO 241 241 241 PRO PRO A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 THR 243 243 243 THR THR A . n 
A 1 244 GLN 244 244 244 GLN GLN A . n 
A 1 245 ASP 245 245 245 ASP ASP A . n 
A 1 246 HIS 246 246 246 HIS HIS A . n 
A 1 247 VAL 247 247 247 VAL VAL A . n 
A 1 248 ASP 248 248 248 ASP ASP A . n 
A 1 249 ILE 249 249 249 ILE ILE A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 PRO 252 252 252 PRO PRO A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 SER 254 254 254 SER SER A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 THR 257 257 257 THR THR A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 ILE 259 259 259 ILE ILE A . n 
A 1 260 ALA 260 260 260 ALA ALA A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 LEU 262 262 262 LEU LEU A . n 
A 1 263 ASP 263 263 263 ASP ASP A . n 
A 1 264 MET 264 264 264 MET MET A . n 
A 1 265 CYS 265 265 265 CYS CYS A . n 
A 1 266 ALA 266 266 266 ALA ALA A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 LYS 269 269 269 LYS LYS A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 LEU 271 271 271 LEU LEU A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 ASN 274 274 274 ASN ASN A . n 
A 1 275 GLY 275 275 275 GLY GLY A . n 
A 1 276 MET 276 276 276 MET MET A . n 
A 1 277 ASN 277 277 277 ASN ASN A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 ARG 279 279 279 ARG ARG A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 ILE 281 281 281 ILE ILE A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 GLY 283 283 283 GLY GLY A . n 
A 1 284 SER 284 284 284 SER SER A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 LEU 286 286 286 LEU LEU A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 ASP 289 289 289 ASP ASP A . n 
A 1 290 GLU 290 290 290 GLU GLU A . n 
A 1 291 PHE 291 291 291 PHE PHE A . n 
A 1 292 THR 292 292 292 THR THR A . n 
A 1 293 PRO 293 293 293 PRO PRO A . n 
A 1 294 PHE 294 294 294 PHE PHE A . n 
A 1 295 ASP 295 295 295 ASP ASP A . n 
A 1 296 VAL 296 296 296 VAL VAL A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 GLN 299 299 299 GLN GLN A . n 
A 1 300 CYS 300 300 300 CYS CYS A . n 
A 1 301 SER 301 301 301 SER SER A . n 
A 1 302 GLY 302 302 302 GLY GLY A . n 
A 1 303 VAL 303 303 303 VAL VAL A . n 
A 1 304 THR 304 304 304 THR THR A . n 
A 1 305 PHE 305 306 306 PHE PHE A . n 
A 1 306 GLN 306 307 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        4WI 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   4WI 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 4WI 1   401 999 4WI NMA A . 
C 3 HOH 1   501 295 HOH HOH A . 
C 3 HOH 2   502 193 HOH HOH A . 
C 3 HOH 3   503 323 HOH HOH A . 
C 3 HOH 4   504 144 HOH HOH A . 
C 3 HOH 5   505 221 HOH HOH A . 
C 3 HOH 6   506 280 HOH HOH A . 
C 3 HOH 7   507 174 HOH HOH A . 
C 3 HOH 8   508 169 HOH HOH A . 
C 3 HOH 9   509 79  HOH HOH A . 
C 3 HOH 10  510 229 HOH HOH A . 
C 3 HOH 11  511 311 HOH HOH A . 
C 3 HOH 12  512 292 HOH HOH A . 
C 3 HOH 13  513 200 HOH HOH A . 
C 3 HOH 14  514 209 HOH HOH A . 
C 3 HOH 15  515 88  HOH HOH A . 
C 3 HOH 16  516 55  HOH HOH A . 
C 3 HOH 17  517 29  HOH HOH A . 
C 3 HOH 18  518 15  HOH HOH A . 
C 3 HOH 19  519 252 HOH HOH A . 
C 3 HOH 20  520 235 HOH HOH A . 
C 3 HOH 21  521 51  HOH HOH A . 
C 3 HOH 22  522 10  HOH HOH A . 
C 3 HOH 23  523 121 HOH HOH A . 
C 3 HOH 24  524 81  HOH HOH A . 
C 3 HOH 25  525 133 HOH HOH A . 
C 3 HOH 26  526 114 HOH HOH A . 
C 3 HOH 27  527 217 HOH HOH A . 
C 3 HOH 28  528 233 HOH HOH A . 
C 3 HOH 29  529 57  HOH HOH A . 
C 3 HOH 30  530 109 HOH HOH A . 
C 3 HOH 31  531 185 HOH HOH A . 
C 3 HOH 32  532 101 HOH HOH A . 
C 3 HOH 33  533 5   HOH HOH A . 
C 3 HOH 34  534 166 HOH HOH A . 
C 3 HOH 35  535 25  HOH HOH A . 
C 3 HOH 36  536 50  HOH HOH A . 
C 3 HOH 37  537 190 HOH HOH A . 
C 3 HOH 38  538 291 HOH HOH A . 
C 3 HOH 39  539 141 HOH HOH A . 
C 3 HOH 40  540 247 HOH HOH A . 
C 3 HOH 41  541 284 HOH HOH A . 
C 3 HOH 42  542 277 HOH HOH A . 
C 3 HOH 43  543 17  HOH HOH A . 
C 3 HOH 44  544 8   HOH HOH A . 
C 3 HOH 45  545 71  HOH HOH A . 
C 3 HOH 46  546 313 HOH HOH A . 
C 3 HOH 47  547 11  HOH HOH A . 
C 3 HOH 48  548 82  HOH HOH A . 
C 3 HOH 49  549 45  HOH HOH A . 
C 3 HOH 50  550 22  HOH HOH A . 
C 3 HOH 51  551 126 HOH HOH A . 
C 3 HOH 52  552 2   HOH HOH A . 
C 3 HOH 53  553 73  HOH HOH A . 
C 3 HOH 54  554 222 HOH HOH A . 
C 3 HOH 55  555 63  HOH HOH A . 
C 3 HOH 56  556 272 HOH HOH A . 
C 3 HOH 57  557 37  HOH HOH A . 
C 3 HOH 58  558 59  HOH HOH A . 
C 3 HOH 59  559 103 HOH HOH A . 
C 3 HOH 60  560 46  HOH HOH A . 
C 3 HOH 61  561 179 HOH HOH A . 
C 3 HOH 62  562 49  HOH HOH A . 
C 3 HOH 63  563 95  HOH HOH A . 
C 3 HOH 64  564 77  HOH HOH A . 
C 3 HOH 65  565 93  HOH HOH A . 
C 3 HOH 66  566 237 HOH HOH A . 
C 3 HOH 67  567 232 HOH HOH A . 
C 3 HOH 68  568 202 HOH HOH A . 
C 3 HOH 69  569 39  HOH HOH A . 
C 3 HOH 70  570 56  HOH HOH A . 
C 3 HOH 71  571 146 HOH HOH A . 
C 3 HOH 72  572 201 HOH HOH A . 
C 3 HOH 73  573 6   HOH HOH A . 
C 3 HOH 74  574 136 HOH HOH A . 
C 3 HOH 75  575 245 HOH HOH A . 
C 3 HOH 76  576 303 HOH HOH A . 
C 3 HOH 77  577 54  HOH HOH A . 
C 3 HOH 78  578 40  HOH HOH A . 
C 3 HOH 79  579 41  HOH HOH A . 
C 3 HOH 80  580 44  HOH HOH A . 
C 3 HOH 81  581 72  HOH HOH A . 
C 3 HOH 82  582 328 HOH HOH A . 
C 3 HOH 83  583 118 HOH HOH A . 
C 3 HOH 84  584 38  HOH HOH A . 
C 3 HOH 85  585 197 HOH HOH A . 
C 3 HOH 86  586 24  HOH HOH A . 
C 3 HOH 87  587 240 HOH HOH A . 
C 3 HOH 88  588 26  HOH HOH A . 
C 3 HOH 89  589 281 HOH HOH A . 
C 3 HOH 90  590 53  HOH HOH A . 
C 3 HOH 91  591 130 HOH HOH A . 
C 3 HOH 92  592 83  HOH HOH A . 
C 3 HOH 93  593 4   HOH HOH A . 
C 3 HOH 94  594 231 HOH HOH A . 
C 3 HOH 95  595 58  HOH HOH A . 
C 3 HOH 96  596 207 HOH HOH A . 
C 3 HOH 97  597 219 HOH HOH A . 
C 3 HOH 98  598 47  HOH HOH A . 
C 3 HOH 99  599 131 HOH HOH A . 
C 3 HOH 100 600 195 HOH HOH A . 
C 3 HOH 101 601 67  HOH HOH A . 
C 3 HOH 102 602 3   HOH HOH A . 
C 3 HOH 103 603 69  HOH HOH A . 
C 3 HOH 104 604 96  HOH HOH A . 
C 3 HOH 105 605 21  HOH HOH A . 
C 3 HOH 106 606 218 HOH HOH A . 
C 3 HOH 107 607 31  HOH HOH A . 
C 3 HOH 108 608 213 HOH HOH A . 
C 3 HOH 109 609 147 HOH HOH A . 
C 3 HOH 110 610 203 HOH HOH A . 
C 3 HOH 111 611 140 HOH HOH A . 
C 3 HOH 112 612 1   HOH HOH A . 
C 3 HOH 113 613 64  HOH HOH A . 
C 3 HOH 114 614 78  HOH HOH A . 
C 3 HOH 115 615 65  HOH HOH A . 
C 3 HOH 116 616 12  HOH HOH A . 
C 3 HOH 117 617 105 HOH HOH A . 
C 3 HOH 118 618 120 HOH HOH A . 
C 3 HOH 119 619 176 HOH HOH A . 
C 3 HOH 120 620 152 HOH HOH A . 
C 3 HOH 121 621 324 HOH HOH A . 
C 3 HOH 122 622 189 HOH HOH A . 
C 3 HOH 123 623 13  HOH HOH A . 
C 3 HOH 124 624 159 HOH HOH A . 
C 3 HOH 125 625 86  HOH HOH A . 
C 3 HOH 126 626 90  HOH HOH A . 
C 3 HOH 127 627 89  HOH HOH A . 
C 3 HOH 128 628 327 HOH HOH A . 
C 3 HOH 129 629 163 HOH HOH A . 
C 3 HOH 130 630 76  HOH HOH A . 
C 3 HOH 131 631 62  HOH HOH A . 
C 3 HOH 132 632 178 HOH HOH A . 
C 3 HOH 133 633 33  HOH HOH A . 
C 3 HOH 134 634 199 HOH HOH A . 
C 3 HOH 135 635 113 HOH HOH A . 
C 3 HOH 136 636 92  HOH HOH A . 
C 3 HOH 137 637 107 HOH HOH A . 
C 3 HOH 138 638 170 HOH HOH A . 
C 3 HOH 139 639 124 HOH HOH A . 
C 3 HOH 140 640 27  HOH HOH A . 
C 3 HOH 141 641 149 HOH HOH A . 
C 3 HOH 142 642 154 HOH HOH A . 
C 3 HOH 143 643 310 HOH HOH A . 
C 3 HOH 144 644 204 HOH HOH A . 
C 3 HOH 145 645 60  HOH HOH A . 
C 3 HOH 146 646 171 HOH HOH A . 
C 3 HOH 147 647 7   HOH HOH A . 
C 3 HOH 148 648 142 HOH HOH A . 
C 3 HOH 149 649 134 HOH HOH A . 
C 3 HOH 150 650 161 HOH HOH A . 
C 3 HOH 151 651 70  HOH HOH A . 
C 3 HOH 152 652 151 HOH HOH A . 
C 3 HOH 153 653 98  HOH HOH A . 
C 3 HOH 154 654 20  HOH HOH A . 
C 3 HOH 155 655 23  HOH HOH A . 
C 3 HOH 156 656 18  HOH HOH A . 
C 3 HOH 157 657 68  HOH HOH A . 
C 3 HOH 158 658 16  HOH HOH A . 
C 3 HOH 159 659 282 HOH HOH A . 
C 3 HOH 160 660 294 HOH HOH A . 
C 3 HOH 161 661 175 HOH HOH A . 
C 3 HOH 162 662 19  HOH HOH A . 
C 3 HOH 163 663 319 HOH HOH A . 
C 3 HOH 164 664 315 HOH HOH A . 
C 3 HOH 165 665 164 HOH HOH A . 
C 3 HOH 166 666 208 HOH HOH A . 
C 3 HOH 167 667 205 HOH HOH A . 
C 3 HOH 168 668 84  HOH HOH A . 
C 3 HOH 169 669 230 HOH HOH A . 
C 3 HOH 170 670 160 HOH HOH A . 
C 3 HOH 171 671 102 HOH HOH A . 
C 3 HOH 172 672 36  HOH HOH A . 
C 3 HOH 173 673 184 HOH HOH A . 
C 3 HOH 174 674 104 HOH HOH A . 
C 3 HOH 175 675 34  HOH HOH A . 
C 3 HOH 176 676 182 HOH HOH A . 
C 3 HOH 177 677 228 HOH HOH A . 
C 3 HOH 178 678 278 HOH HOH A . 
C 3 HOH 179 679 155 HOH HOH A . 
C 3 HOH 180 680 52  HOH HOH A . 
C 3 HOH 181 681 265 HOH HOH A . 
C 3 HOH 182 682 43  HOH HOH A . 
C 3 HOH 183 683 150 HOH HOH A . 
C 3 HOH 184 684 242 HOH HOH A . 
C 3 HOH 185 685 14  HOH HOH A . 
C 3 HOH 186 686 116 HOH HOH A . 
C 3 HOH 187 687 66  HOH HOH A . 
C 3 HOH 188 688 9   HOH HOH A . 
C 3 HOH 189 689 85  HOH HOH A . 
C 3 HOH 190 690 300 HOH HOH A . 
C 3 HOH 191 691 108 HOH HOH A . 
C 3 HOH 192 692 132 HOH HOH A . 
C 3 HOH 193 693 279 HOH HOH A . 
C 3 HOH 194 694 91  HOH HOH A . 
C 3 HOH 195 695 153 HOH HOH A . 
C 3 HOH 196 696 325 HOH HOH A . 
C 3 HOH 197 697 259 HOH HOH A . 
C 3 HOH 198 698 87  HOH HOH A . 
C 3 HOH 199 699 308 HOH HOH A . 
C 3 HOH 200 700 167 HOH HOH A . 
C 3 HOH 201 701 304 HOH HOH A . 
C 3 HOH 202 702 100 HOH HOH A . 
C 3 HOH 203 703 236 HOH HOH A . 
C 3 HOH 204 704 216 HOH HOH A . 
C 3 HOH 205 705 312 HOH HOH A . 
C 3 HOH 206 706 301 HOH HOH A . 
C 3 HOH 207 707 94  HOH HOH A . 
C 3 HOH 208 708 187 HOH HOH A . 
C 3 HOH 209 709 32  HOH HOH A . 
C 3 HOH 210 710 110 HOH HOH A . 
C 3 HOH 211 711 111 HOH HOH A . 
C 3 HOH 212 712 186 HOH HOH A . 
C 3 HOH 213 713 139 HOH HOH A . 
C 3 HOH 214 714 223 HOH HOH A . 
C 3 HOH 215 715 331 HOH HOH A . 
C 3 HOH 216 716 117 HOH HOH A . 
C 3 HOH 217 717 112 HOH HOH A . 
C 3 HOH 218 718 30  HOH HOH A . 
C 3 HOH 219 719 268 HOH HOH A . 
C 3 HOH 220 720 128 HOH HOH A . 
C 3 HOH 221 721 198 HOH HOH A . 
C 3 HOH 222 722 314 HOH HOH A . 
C 3 HOH 223 723 156 HOH HOH A . 
C 3 HOH 224 724 234 HOH HOH A . 
C 3 HOH 225 725 99  HOH HOH A . 
C 3 HOH 226 726 214 HOH HOH A . 
C 3 HOH 227 727 271 HOH HOH A . 
C 3 HOH 228 728 307 HOH HOH A . 
C 3 HOH 229 729 264 HOH HOH A . 
C 3 HOH 230 730 263 HOH HOH A . 
C 3 HOH 231 731 293 HOH HOH A . 
C 3 HOH 232 732 138 HOH HOH A . 
C 3 HOH 233 733 243 HOH HOH A . 
C 3 HOH 234 734 80  HOH HOH A . 
C 3 HOH 235 735 183 HOH HOH A . 
C 3 HOH 236 736 35  HOH HOH A . 
C 3 HOH 237 737 322 HOH HOH A . 
C 3 HOH 238 738 226 HOH HOH A . 
C 3 HOH 239 739 309 HOH HOH A . 
C 3 HOH 240 740 157 HOH HOH A . 
C 3 HOH 241 741 74  HOH HOH A . 
C 3 HOH 242 742 270 HOH HOH A . 
C 3 HOH 243 743 275 HOH HOH A . 
C 3 HOH 244 744 260 HOH HOH A . 
C 3 HOH 245 745 290 HOH HOH A . 
C 3 HOH 246 746 75  HOH HOH A . 
C 3 HOH 247 747 250 HOH HOH A . 
C 3 HOH 248 748 317 HOH HOH A . 
C 3 HOH 249 749 262 HOH HOH A . 
C 3 HOH 250 750 330 HOH HOH A . 
C 3 HOH 251 751 258 HOH HOH A . 
C 3 HOH 252 752 306 HOH HOH A . 
C 3 HOH 253 753 106 HOH HOH A . 
C 3 HOH 254 754 192 HOH HOH A . 
C 3 HOH 255 755 158 HOH HOH A . 
C 3 HOH 256 756 266 HOH HOH A . 
C 3 HOH 257 757 321 HOH HOH A . 
C 3 HOH 258 758 286 HOH HOH A . 
C 3 HOH 259 759 165 HOH HOH A . 
C 3 HOH 260 760 249 HOH HOH A . 
C 3 HOH 261 761 173 HOH HOH A . 
C 3 HOH 262 762 211 HOH HOH A . 
C 3 HOH 263 763 123 HOH HOH A . 
C 3 HOH 264 764 143 HOH HOH A . 
C 3 HOH 265 765 285 HOH HOH A . 
C 3 HOH 266 766 148 HOH HOH A . 
C 3 HOH 267 767 241 HOH HOH A . 
C 3 HOH 268 768 145 HOH HOH A . 
C 3 HOH 269 769 188 HOH HOH A . 
C 3 HOH 270 770 196 HOH HOH A . 
C 3 HOH 271 771 194 HOH HOH A . 
C 3 HOH 272 772 274 HOH HOH A . 
C 3 HOH 273 773 329 HOH HOH A . 
C 3 HOH 274 774 256 HOH HOH A . 
C 3 HOH 275 775 119 HOH HOH A . 
C 3 HOH 276 776 122 HOH HOH A . 
C 3 HOH 277 777 127 HOH HOH A . 
C 3 HOH 278 778 210 HOH HOH A . 
C 3 HOH 279 779 215 HOH HOH A . 
C 3 HOH 280 780 206 HOH HOH A . 
C 3 HOH 281 781 318 HOH HOH A . 
C 3 HOH 282 782 220 HOH HOH A . 
C 3 HOH 283 783 191 HOH HOH A . 
C 3 HOH 284 784 267 HOH HOH A . 
C 3 HOH 285 785 172 HOH HOH A . 
C 3 HOH 286 786 251 HOH HOH A . 
C 3 HOH 287 787 239 HOH HOH A . 
C 3 HOH 288 788 248 HOH HOH A . 
C 3 HOH 289 789 273 HOH HOH A . 
C 3 HOH 290 790 181 HOH HOH A . 
C 3 HOH 291 791 42  HOH HOH A . 
C 3 HOH 292 792 244 HOH HOH A . 
C 3 HOH 293 793 115 HOH HOH A . 
C 3 HOH 294 794 254 HOH HOH A . 
C 3 HOH 295 795 125 HOH HOH A . 
C 3 HOH 296 796 129 HOH HOH A . 
C 3 HOH 297 797 135 HOH HOH A . 
C 3 HOH 298 798 269 HOH HOH A . 
C 3 HOH 299 799 257 HOH HOH A . 
C 3 HOH 300 800 246 HOH HOH A . 
C 3 HOH 301 801 180 HOH HOH A . 
C 3 HOH 302 802 283 HOH HOH A . 
C 3 HOH 303 803 177 HOH HOH A . 
C 3 HOH 304 804 316 HOH HOH A . 
C 3 HOH 305 805 289 HOH HOH A . 
C 3 HOH 306 806 297 HOH HOH A . 
C 3 HOH 307 807 168 HOH HOH A . 
C 3 HOH 308 808 320 HOH HOH A . 
C 3 HOH 309 809 28  HOH HOH A . 
C 3 HOH 310 810 305 HOH HOH A . 
C 3 HOH 311 811 261 HOH HOH A . 
C 3 HOH 312 812 326 HOH HOH A . 
C 3 HOH 313 813 224 HOH HOH A . 
C 3 HOH 314 814 225 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A SER 46 ? OG  ? A SER 46 OG  
2  1 Y 1 A GLU 47 ? CG  ? A GLU 47 CG  
3  1 Y 1 A GLU 47 ? CD  ? A GLU 47 CD  
4  1 Y 1 A GLU 47 ? OE1 ? A GLU 47 OE1 
5  1 Y 1 A GLU 47 ? OE2 ? A GLU 47 OE2 
6  1 Y 1 A ILE 59 ? CG1 ? A ILE 59 CG1 
7  1 Y 1 A ILE 59 ? CG2 ? A ILE 59 CG2 
8  1 Y 1 A ILE 59 ? CD1 ? A ILE 59 CD1 
9  1 Y 1 A ARG 60 ? CG  ? A ARG 60 CG  
10 1 Y 1 A ARG 60 ? CD  ? A ARG 60 CD  
11 1 Y 1 A ARG 60 ? NE  ? A ARG 60 NE  
12 1 Y 1 A ARG 60 ? CZ  ? A ARG 60 CZ  
13 1 Y 1 A ARG 60 ? NH1 ? A ARG 60 NH1 
14 1 Y 1 A ARG 60 ? NH2 ? A ARG 60 NH2 
15 1 Y 1 A ASN 72 ? CG  ? A ASN 72 CG  
16 1 Y 1 A ASN 72 ? OD1 ? A ASN 72 OD1 
17 1 Y 1 A ASN 72 ? ND2 ? A ASN 72 ND2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BO7 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     45.497 
_cell.length_a_esd                 ? 
_cell.length_b                     64.164 
_cell.length_b_esd                 ? 
_cell.length_c                     105.490 
_cell.length_c_esd                 ? 
_cell.volume                       307953.740 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BO7 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                18 
_symmetry.space_group_name_Hall            'P 2 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BO7 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.27 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          45.90 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              6.0 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M MES monohydrate pH 6.0, 20% v/v Jeffamine M-600 pH 7.0' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            294 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-09-15 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.979330 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSLS-II BEAMLINE 17-ID-2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.979330 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   17-ID-2 
_diffrn_source.pdbx_synchrotron_site       NSLS-II 
# 
_reflns.B_iso_Wilson_estimate                          16.50 
_reflns.entry_id                                       9BO7 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.54 
_reflns.d_resolution_low                               40.75 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     42592 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           91.51 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                11.7 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          8.7 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.997 
_reflns.pdbx_CC_star                                   0.999 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.1821 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.54 
_reflns_shell.d_res_low                                     1.597 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           0.74 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3915 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               6.1 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.356 
_reflns_shell.pdbx_CC_star                                  0.725 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          85.56 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.455 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               19.78 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9BO7 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.54 
_refine.ls_d_res_low                             40.75 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     42494 
_refine.ls_number_reflns_R_free                  2074 
_refine.ls_number_reflns_R_work                  40420 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    91.52 
_refine.ls_percent_reflns_R_free                 4.88 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1910 
_refine.ls_R_factor_R_free                       0.2241 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1894 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 22.8757 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1886 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.54 
_refine_hist.d_res_low                        40.75 
_refine_hist.number_atoms_solvent             314 
_refine_hist.number_atoms_total               2693 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2344 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         35 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0048  ? 2480 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.8067  ? 3394 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0473  ? 383  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0054  ? 437  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 10.9265 ? 888  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.54 1.58  . . 117 2429 83.45  . . . . 0.3092 . . . . . . . . . . . 0.3233 
'X-RAY DIFFRACTION' 1.58 1.62  . . 148 2627 91.25  . . . . 0.2793 . . . . . . . . . . . 0.3138 
'X-RAY DIFFRACTION' 1.62 1.66  . . 151 2847 98.30  . . . . 0.2659 . . . . . . . . . . . 0.2999 
'X-RAY DIFFRACTION' 1.66 1.71  . . 144 2903 99.61  . . . . 0.2327 . . . . . . . . . . . 0.2635 
'X-RAY DIFFRACTION' 1.71 1.76  . . 144 2906 100.00 . . . . 0.2169 . . . . . . . . . . . 0.2837 
'X-RAY DIFFRACTION' 1.76 1.83  . . 147 2927 100.00 . . . . 0.2066 . . . . . . . . . . . 0.2512 
'X-RAY DIFFRACTION' 1.83 1.90  . . 99  2056 70.73  . . . . 0.2176 . . . . . . . . . . . 0.2389 
'X-RAY DIFFRACTION' 1.90 1.99  . . 79  1398 47.95  . . . . 0.1962 . . . . . . . . . . . 0.2374 
'X-RAY DIFFRACTION' 1.99 2.09  . . 130 2933 99.93  . . . . 0.1822 . . . . . . . . . . . 0.2520 
'X-RAY DIFFRACTION' 2.09 2.22  . . 148 2939 100.00 . . . . 0.1792 . . . . . . . . . . . 0.2305 
'X-RAY DIFFRACTION' 2.22 2.39  . . 134 2532 85.42  . . . . 0.1797 . . . . . . . . . . . 0.2220 
'X-RAY DIFFRACTION' 2.39 2.64  . . 178 2900 100.00 . . . . 0.1886 . . . . . . . . . . . 0.2263 
'X-RAY DIFFRACTION' 2.64 3.02  . . 141 3007 100.00 . . . . 0.1890 . . . . . . . . . . . 0.2259 
'X-RAY DIFFRACTION' 3.02 3.80  . . 141 2875 95.44  . . . . 0.1678 . . . . . . . . . . . 0.1867 
'X-RAY DIFFRACTION' 3.80 40.75 . . 173 3141 99.91  . . . . 0.1677 . . . . . . . . . . . 0.1911 
# 
_struct.entry_id                     9BO7 
_struct.title                        'Crystal Structure of L50F SARS-CoV-2 Main Protease in Complex with Nirmatrelvir' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BO7 
_struct_keywords.text            'Hydrolase, VIRAL PROTEIN' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1AB_SARS2 
_struct_ref.pdbx_db_accession          P0DTD1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_struct_ref.pdbx_align_begin           3264 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9BO7 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 306 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P0DTD1 
_struct_ref_seq.db_align_beg                  3264 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3569 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       307 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             9BO7 
_struct_ref_seq_dif.mon_id                       PHE 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      50 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   P0DTD1 
_struct_ref_seq_dif.db_mon_id                    LEU 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          3313 
_struct_ref_seq_dif.details                      conflict 
_struct_ref_seq_dif.pdbx_auth_seq_num            50 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 3080  ? 
1 MORE         -14   ? 
1 'SSA (A^2)'  24570 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z     1.0000000000  0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  
0.0000000000 0.0000000000  0.0000000000 0.0000000000 1.0000000000 0.0000000000 
2 'crystal symmetry operation' 2_565 -x,-y+1,z -1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 
0.0000000000 64.1640000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 10  ? GLY A 15  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 41  ? CYS A 44  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 THR A 45  ? ASN A 51  ? THR A 45  ASN A 51  5 ? 7  
HELX_P HELX_P4  AA4 ASN A 53  ? ARG A 60  ? ASN A 53  ARG A 60  1 ? 8  
HELX_P HELX_P5  AA5 SER A 62  ? HIS A 64  ? SER A 62  HIS A 64  5 ? 3  
HELX_P HELX_P6  AA6 ILE A 200 ? ASN A 214 ? ILE A 200 ASN A 214 1 ? 15 
HELX_P HELX_P7  AA7 THR A 226 ? TYR A 237 ? THR A 226 TYR A 237 1 ? 12 
HELX_P HELX_P8  AA8 THR A 243 ? LEU A 250 ? THR A 243 LEU A 250 1 ? 8  
HELX_P HELX_P9  AA9 LEU A 250 ? GLY A 258 ? LEU A 250 GLY A 258 1 ? 9  
HELX_P HELX_P10 AB1 ALA A 260 ? GLY A 275 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P11 AB2 THR A 292 ? GLY A 302 ? THR A 292 GLY A 302 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            covale1 
_struct_conn.conn_type_id                  covale 
_struct_conn.pdbx_leaving_atom_flag        none 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            145 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           B 
_struct_conn.ptnr2_label_comp_id           4WI 
_struct_conn.ptnr2_label_seq_id            . 
_struct_conn.ptnr2_label_atom_id           C3 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             145 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            4WI 
_struct_conn.ptnr2_auth_seq_id             401 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               1.766 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      4WI 
_pdbx_modification_feature.label_asym_id                      B 
_pdbx_modification_feature.label_seq_id                       . 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      145 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       4WI 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        401 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       145 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               C3 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                CYS 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        4WI 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Covalent chemical modification' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 73  ? LEU A 75  ? VAL A 73  LEU A 75  
AA1 2 PHE A 66  ? ALA A 70  ? PHE A 66  ALA A 70  
AA1 3 MET A 17  ? CYS A 22  ? MET A 17  CYS A 22  
AA1 4 THR A 25  ? LEU A 32  ? THR A 25  LEU A 32  
AA1 5 VAL A 35  ? PRO A 39  ? VAL A 35  PRO A 39  
AA1 6 VAL A 86  ? VAL A 91  ? VAL A 86  VAL A 91  
AA1 7 VAL A 77  ? GLN A 83  ? VAL A 77  GLN A 83  
AA2 1 LYS A 100 ? PHE A 103 ? LYS A 100 PHE A 103 
AA2 2 CYS A 156 ? LEU A 167 ? CYS A 156 LEU A 167 
AA2 3 VAL A 148 ? ASP A 153 ? VAL A 148 ASP A 153 
AA2 4 THR A 111 ? TYR A 118 ? THR A 111 TYR A 118 
AA2 5 SER A 121 ? ALA A 129 ? SER A 121 ALA A 129 
AA3 1 LYS A 100 ? PHE A 103 ? LYS A 100 PHE A 103 
AA3 2 CYS A 156 ? LEU A 167 ? CYS A 156 LEU A 167 
AA3 3 VAL A 171 ? THR A 175 ? VAL A 171 THR A 175 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O LEU A 75  ? O LEU A 75  N VAL A 68  ? N VAL A 68  
AA1 2 3 O LEU A 67  ? O LEU A 67  N THR A 21  ? N THR A 21  
AA1 3 4 N VAL A 20  ? N VAL A 20  O LEU A 27  ? O LEU A 27  
AA1 4 5 N LEU A 32  ? N LEU A 32  O VAL A 35  ? O VAL A 35  
AA1 5 6 N VAL A 36  ? N VAL A 36  O LEU A 89  ? O LEU A 89  
AA1 6 7 O LYS A 88  ? O LYS A 88  N SER A 81  ? N SER A 81  
AA2 1 2 N LYS A 100 ? N LYS A 100 O VAL A 157 ? O VAL A 157 
AA2 2 3 O SER A 158 ? O SER A 158 N ASN A 151 ? N ASN A 151 
AA2 3 4 O PHE A 150 ? O PHE A 150 N SER A 113 ? N SER A 113 
AA2 4 5 N ALA A 116 ? N ALA A 116 O SER A 123 ? O SER A 123 
AA3 1 2 N LYS A 100 ? N LYS A 100 O VAL A 157 ? O VAL A 157 
AA3 2 3 N LEU A 167 ? N LEU A 167 O VAL A 171 ? O VAL A 171 
# 
_pdbx_entry_details.entry_id                   9BO7 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 33  ? ? 52.41  -130.11 
2 1 ASN A 72  ? ? -99.06 35.57   
3 1 ASN A 84  ? ? 55.24  -122.16 
4 1 TYR A 154 ? ? 59.93  -104.26 
5 1 THR A 169 ? ? 85.51  6.07    
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x+1/2,y+1/2,-z 
4 -x,-y,z         
# 
_pdbx_unobs_or_zero_occ_residues.id               1 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num    1 
_pdbx_unobs_or_zero_occ_residues.polymer_flag     Y 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag   1 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id     A 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id     GLN 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id      307 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code     ? 
_pdbx_unobs_or_zero_occ_residues.label_asym_id    A 
_pdbx_unobs_or_zero_occ_residues.label_comp_id    GLN 
_pdbx_unobs_or_zero_occ_residues.label_seq_id     306 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
4WI C8   C N N 1   
4WI C3   C N N 2   
4WI C1   C N N 3   
4WI C13  C N N 4   
4WI C21  C N N 5   
4WI C6   C N N 6   
4WI C7   C N N 7   
4WI C10  C N N 8   
4WI C5   C N S 9   
4WI C9   C N S 10  
4WI C11  C N S 11  
4WI C12  C N R 12  
4WI C18  C N N 13  
4WI C19  C N N 14  
4WI C20  C N N 15  
4WI C16  C N N 16  
4WI C17  C N N 17  
4WI C23  C N N 18  
4WI C4   C N N 19  
4WI C2   C N S 20  
4WI C14  C N S 21  
4WI C22  C N N 22  
4WI C15  C N N 23  
4WI N5   N N N 24  
4WI N2   N N N 25  
4WI N3   N N N 26  
4WI N1   N N N 27  
4WI N4   N N N 28  
4WI O1   O N N 29  
4WI O2   O N N 30  
4WI O3   O N N 31  
4WI O4   O N N 32  
4WI F1   F N N 33  
4WI F2   F N N 34  
4WI F3   F N N 35  
4WI H33  H N N 36  
4WI H5   H N N 37  
4WI H6   H N N 38  
4WI H7   H N N 39  
4WI H8   H N N 40  
4WI H11  H N N 41  
4WI H12  H N N 42  
4WI H4   H N N 43  
4WI H10  H N N 44  
4WI H13  H N N 45  
4WI H14  H N N 46  
4WI H23  H N N 47  
4WI H24  H N N 48  
4WI H25  H N N 49  
4WI H26  H N N 50  
4WI H27  H N N 51  
4WI H28  H N N 52  
4WI H17  H N N 53  
4WI H19  H N N 54  
4WI H18  H N N 55  
4WI H20  H N N 56  
4WI H21  H N N 57  
4WI H22  H N N 58  
4WI H29  H N N 59  
4WI H30  H N N 60  
4WI H31  H N N 61  
4WI H2   H N N 62  
4WI H3   H N N 63  
4WI H32  H N N 64  
4WI H15  H N N 65  
4WI H36  H N N 66  
4WI H9   H N N 67  
4WI H1   H N N 68  
4WI H16  H N N 69  
ALA N    N N N 70  
ALA CA   C N S 71  
ALA C    C N N 72  
ALA O    O N N 73  
ALA CB   C N N 74  
ALA OXT  O N N 75  
ALA H    H N N 76  
ALA H2   H N N 77  
ALA HA   H N N 78  
ALA HB1  H N N 79  
ALA HB2  H N N 80  
ALA HB3  H N N 81  
ALA HXT  H N N 82  
ARG N    N N N 83  
ARG CA   C N S 84  
ARG C    C N N 85  
ARG O    O N N 86  
ARG CB   C N N 87  
ARG CG   C N N 88  
ARG CD   C N N 89  
ARG NE   N N N 90  
ARG CZ   C N N 91  
ARG NH1  N N N 92  
ARG NH2  N N N 93  
ARG OXT  O N N 94  
ARG H    H N N 95  
ARG H2   H N N 96  
ARG HA   H N N 97  
ARG HB2  H N N 98  
ARG HB3  H N N 99  
ARG HG2  H N N 100 
ARG HG3  H N N 101 
ARG HD2  H N N 102 
ARG HD3  H N N 103 
ARG HE   H N N 104 
ARG HH11 H N N 105 
ARG HH12 H N N 106 
ARG HH21 H N N 107 
ARG HH22 H N N 108 
ARG HXT  H N N 109 
ASN N    N N N 110 
ASN CA   C N S 111 
ASN C    C N N 112 
ASN O    O N N 113 
ASN CB   C N N 114 
ASN CG   C N N 115 
ASN OD1  O N N 116 
ASN ND2  N N N 117 
ASN OXT  O N N 118 
ASN H    H N N 119 
ASN H2   H N N 120 
ASN HA   H N N 121 
ASN HB2  H N N 122 
ASN HB3  H N N 123 
ASN HD21 H N N 124 
ASN HD22 H N N 125 
ASN HXT  H N N 126 
ASP N    N N N 127 
ASP CA   C N S 128 
ASP C    C N N 129 
ASP O    O N N 130 
ASP CB   C N N 131 
ASP CG   C N N 132 
ASP OD1  O N N 133 
ASP OD2  O N N 134 
ASP OXT  O N N 135 
ASP H    H N N 136 
ASP H2   H N N 137 
ASP HA   H N N 138 
ASP HB2  H N N 139 
ASP HB3  H N N 140 
ASP HD2  H N N 141 
ASP HXT  H N N 142 
CYS N    N N N 143 
CYS CA   C N R 144 
CYS C    C N N 145 
CYS O    O N N 146 
CYS CB   C N N 147 
CYS SG   S N N 148 
CYS OXT  O N N 149 
CYS H    H N N 150 
CYS H2   H N N 151 
CYS HA   H N N 152 
CYS HB2  H N N 153 
CYS HB3  H N N 154 
CYS HG   H N N 155 
CYS HXT  H N N 156 
GLN N    N N N 157 
GLN CA   C N S 158 
GLN C    C N N 159 
GLN O    O N N 160 
GLN CB   C N N 161 
GLN CG   C N N 162 
GLN CD   C N N 163 
GLN OE1  O N N 164 
GLN NE2  N N N 165 
GLN OXT  O N N 166 
GLN H    H N N 167 
GLN H2   H N N 168 
GLN HA   H N N 169 
GLN HB2  H N N 170 
GLN HB3  H N N 171 
GLN HG2  H N N 172 
GLN HG3  H N N 173 
GLN HE21 H N N 174 
GLN HE22 H N N 175 
GLN HXT  H N N 176 
GLU N    N N N 177 
GLU CA   C N S 178 
GLU C    C N N 179 
GLU O    O N N 180 
GLU CB   C N N 181 
GLU CG   C N N 182 
GLU CD   C N N 183 
GLU OE1  O N N 184 
GLU OE2  O N N 185 
GLU OXT  O N N 186 
GLU H    H N N 187 
GLU H2   H N N 188 
GLU HA   H N N 189 
GLU HB2  H N N 190 
GLU HB3  H N N 191 
GLU HG2  H N N 192 
GLU HG3  H N N 193 
GLU HE2  H N N 194 
GLU HXT  H N N 195 
GLY N    N N N 196 
GLY CA   C N N 197 
GLY C    C N N 198 
GLY O    O N N 199 
GLY OXT  O N N 200 
GLY H    H N N 201 
GLY H2   H N N 202 
GLY HA2  H N N 203 
GLY HA3  H N N 204 
GLY HXT  H N N 205 
HIS N    N N N 206 
HIS CA   C N S 207 
HIS C    C N N 208 
HIS O    O N N 209 
HIS CB   C N N 210 
HIS CG   C Y N 211 
HIS ND1  N Y N 212 
HIS CD2  C Y N 213 
HIS CE1  C Y N 214 
HIS NE2  N Y N 215 
HIS OXT  O N N 216 
HIS H    H N N 217 
HIS H2   H N N 218 
HIS HA   H N N 219 
HIS HB2  H N N 220 
HIS HB3  H N N 221 
HIS HD1  H N N 222 
HIS HD2  H N N 223 
HIS HE1  H N N 224 
HIS HE2  H N N 225 
HIS HXT  H N N 226 
HOH O    O N N 227 
HOH H1   H N N 228 
HOH H2   H N N 229 
ILE N    N N N 230 
ILE CA   C N S 231 
ILE C    C N N 232 
ILE O    O N N 233 
ILE CB   C N S 234 
ILE CG1  C N N 235 
ILE CG2  C N N 236 
ILE CD1  C N N 237 
ILE OXT  O N N 238 
ILE H    H N N 239 
ILE H2   H N N 240 
ILE HA   H N N 241 
ILE HB   H N N 242 
ILE HG12 H N N 243 
ILE HG13 H N N 244 
ILE HG21 H N N 245 
ILE HG22 H N N 246 
ILE HG23 H N N 247 
ILE HD11 H N N 248 
ILE HD12 H N N 249 
ILE HD13 H N N 250 
ILE HXT  H N N 251 
LEU N    N N N 252 
LEU CA   C N S 253 
LEU C    C N N 254 
LEU O    O N N 255 
LEU CB   C N N 256 
LEU CG   C N N 257 
LEU CD1  C N N 258 
LEU CD2  C N N 259 
LEU OXT  O N N 260 
LEU H    H N N 261 
LEU H2   H N N 262 
LEU HA   H N N 263 
LEU HB2  H N N 264 
LEU HB3  H N N 265 
LEU HG   H N N 266 
LEU HD11 H N N 267 
LEU HD12 H N N 268 
LEU HD13 H N N 269 
LEU HD21 H N N 270 
LEU HD22 H N N 271 
LEU HD23 H N N 272 
LEU HXT  H N N 273 
LYS N    N N N 274 
LYS CA   C N S 275 
LYS C    C N N 276 
LYS O    O N N 277 
LYS CB   C N N 278 
LYS CG   C N N 279 
LYS CD   C N N 280 
LYS CE   C N N 281 
LYS NZ   N N N 282 
LYS OXT  O N N 283 
LYS H    H N N 284 
LYS H2   H N N 285 
LYS HA   H N N 286 
LYS HB2  H N N 287 
LYS HB3  H N N 288 
LYS HG2  H N N 289 
LYS HG3  H N N 290 
LYS HD2  H N N 291 
LYS HD3  H N N 292 
LYS HE2  H N N 293 
LYS HE3  H N N 294 
LYS HZ1  H N N 295 
LYS HZ2  H N N 296 
LYS HZ3  H N N 297 
LYS HXT  H N N 298 
MET N    N N N 299 
MET CA   C N S 300 
MET C    C N N 301 
MET O    O N N 302 
MET CB   C N N 303 
MET CG   C N N 304 
MET SD   S N N 305 
MET CE   C N N 306 
MET OXT  O N N 307 
MET H    H N N 308 
MET H2   H N N 309 
MET HA   H N N 310 
MET HB2  H N N 311 
MET HB3  H N N 312 
MET HG2  H N N 313 
MET HG3  H N N 314 
MET HE1  H N N 315 
MET HE2  H N N 316 
MET HE3  H N N 317 
MET HXT  H N N 318 
PHE N    N N N 319 
PHE CA   C N S 320 
PHE C    C N N 321 
PHE O    O N N 322 
PHE CB   C N N 323 
PHE CG   C Y N 324 
PHE CD1  C Y N 325 
PHE CD2  C Y N 326 
PHE CE1  C Y N 327 
PHE CE2  C Y N 328 
PHE CZ   C Y N 329 
PHE OXT  O N N 330 
PHE H    H N N 331 
PHE H2   H N N 332 
PHE HA   H N N 333 
PHE HB2  H N N 334 
PHE HB3  H N N 335 
PHE HD1  H N N 336 
PHE HD2  H N N 337 
PHE HE1  H N N 338 
PHE HE2  H N N 339 
PHE HZ   H N N 340 
PHE HXT  H N N 341 
PRO N    N N N 342 
PRO CA   C N S 343 
PRO C    C N N 344 
PRO O    O N N 345 
PRO CB   C N N 346 
PRO CG   C N N 347 
PRO CD   C N N 348 
PRO OXT  O N N 349 
PRO H    H N N 350 
PRO HA   H N N 351 
PRO HB2  H N N 352 
PRO HB3  H N N 353 
PRO HG2  H N N 354 
PRO HG3  H N N 355 
PRO HD2  H N N 356 
PRO HD3  H N N 357 
PRO HXT  H N N 358 
SER N    N N N 359 
SER CA   C N S 360 
SER C    C N N 361 
SER O    O N N 362 
SER CB   C N N 363 
SER OG   O N N 364 
SER OXT  O N N 365 
SER H    H N N 366 
SER H2   H N N 367 
SER HA   H N N 368 
SER HB2  H N N 369 
SER HB3  H N N 370 
SER HG   H N N 371 
SER HXT  H N N 372 
THR N    N N N 373 
THR CA   C N S 374 
THR C    C N N 375 
THR O    O N N 376 
THR CB   C N R 377 
THR OG1  O N N 378 
THR CG2  C N N 379 
THR OXT  O N N 380 
THR H    H N N 381 
THR H2   H N N 382 
THR HA   H N N 383 
THR HB   H N N 384 
THR HG1  H N N 385 
THR HG21 H N N 386 
THR HG22 H N N 387 
THR HG23 H N N 388 
THR HXT  H N N 389 
TRP N    N N N 390 
TRP CA   C N S 391 
TRP C    C N N 392 
TRP O    O N N 393 
TRP CB   C N N 394 
TRP CG   C Y N 395 
TRP CD1  C Y N 396 
TRP CD2  C Y N 397 
TRP NE1  N Y N 398 
TRP CE2  C Y N 399 
TRP CE3  C Y N 400 
TRP CZ2  C Y N 401 
TRP CZ3  C Y N 402 
TRP CH2  C Y N 403 
TRP OXT  O N N 404 
TRP H    H N N 405 
TRP H2   H N N 406 
TRP HA   H N N 407 
TRP HB2  H N N 408 
TRP HB3  H N N 409 
TRP HD1  H N N 410 
TRP HE1  H N N 411 
TRP HE3  H N N 412 
TRP HZ2  H N N 413 
TRP HZ3  H N N 414 
TRP HH2  H N N 415 
TRP HXT  H N N 416 
TYR N    N N N 417 
TYR CA   C N S 418 
TYR C    C N N 419 
TYR O    O N N 420 
TYR CB   C N N 421 
TYR CG   C Y N 422 
TYR CD1  C Y N 423 
TYR CD2  C Y N 424 
TYR CE1  C Y N 425 
TYR CE2  C Y N 426 
TYR CZ   C Y N 427 
TYR OH   O N N 428 
TYR OXT  O N N 429 
TYR H    H N N 430 
TYR H2   H N N 431 
TYR HA   H N N 432 
TYR HB2  H N N 433 
TYR HB3  H N N 434 
TYR HD1  H N N 435 
TYR HD2  H N N 436 
TYR HE1  H N N 437 
TYR HE2  H N N 438 
TYR HH   H N N 439 
TYR HXT  H N N 440 
VAL N    N N N 441 
VAL CA   C N S 442 
VAL C    C N N 443 
VAL O    O N N 444 
VAL CB   C N N 445 
VAL CG1  C N N 446 
VAL CG2  C N N 447 
VAL OXT  O N N 448 
VAL H    H N N 449 
VAL H2   H N N 450 
VAL HA   H N N 451 
VAL HB   H N N 452 
VAL HG11 H N N 453 
VAL HG12 H N N 454 
VAL HG13 H N N 455 
VAL HG21 H N N 456 
VAL HG22 H N N 457 
VAL HG23 H N N 458 
VAL HXT  H N N 459 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
4WI O1  C8   doub N N 1   
4WI C8  N2   sing N N 2   
4WI C8  C5   sing N N 3   
4WI N2  C7   sing N N 4   
4WI C4  C5   sing N N 5   
4WI C4  C2   sing N N 6   
4WI C5  C6   sing N N 7   
4WI N5  C3   doub N N 8   
4WI C3  C2   sing N N 9   
4WI C7  C6   sing N N 10  
4WI C2  N1   sing N N 11  
4WI N1  C1   sing N N 12  
4WI F1  C22  sing N N 13  
4WI O3  C13  doub N N 14  
4WI C1  C9   sing N N 15  
4WI C1  O2   doub N N 16  
4WI F3  C22  sing N N 17  
4WI C23 C15  sing N N 18  
4WI C22 F2   sing N N 19  
4WI C22 C21  sing N N 20  
4WI C9  N3   sing N N 21  
4WI C9  C12  sing N N 22  
4WI C13 N3   sing N N 23  
4WI C13 C14  sing N N 24  
4WI N4  C21  sing N N 25  
4WI N4  C14  sing N N 26  
4WI C19 C18  sing N N 27  
4WI N3  C10  sing N N 28  
4WI C21 O4   doub N N 29  
4WI C12 C18  sing N N 30  
4WI C12 C11  sing N N 31  
4WI C14 C15  sing N N 32  
4WI C15 C17  sing N N 33  
4WI C15 C16  sing N N 34  
4WI C18 C20  sing N N 35  
4WI C18 C11  sing N N 36  
4WI C10 C11  sing N N 37  
4WI C3  H33  sing N N 38  
4WI C6  H5   sing N N 39  
4WI C6  H6   sing N N 40  
4WI C7  H7   sing N N 41  
4WI C7  H8   sing N N 42  
4WI C10 H11  sing N N 43  
4WI C10 H12  sing N N 44  
4WI C5  H4   sing N N 45  
4WI C9  H10  sing N N 46  
4WI C11 H13  sing N N 47  
4WI C12 H14  sing N N 48  
4WI C19 H23  sing N N 49  
4WI C19 H24  sing N N 50  
4WI C19 H25  sing N N 51  
4WI C20 H26  sing N N 52  
4WI C20 H27  sing N N 53  
4WI C20 H28  sing N N 54  
4WI C16 H17  sing N N 55  
4WI C16 H19  sing N N 56  
4WI C16 H18  sing N N 57  
4WI C17 H20  sing N N 58  
4WI C17 H21  sing N N 59  
4WI C17 H22  sing N N 60  
4WI C23 H29  sing N N 61  
4WI C23 H30  sing N N 62  
4WI C23 H31  sing N N 63  
4WI C4  H2   sing N N 64  
4WI C4  H3   sing N N 65  
4WI C2  H32  sing N N 66  
4WI C14 H15  sing N N 67  
4WI N5  H36  sing N N 68  
4WI N2  H9   sing N N 69  
4WI N1  H1   sing N N 70  
4WI N4  H16  sing N N 71  
ALA N   CA   sing N N 72  
ALA N   H    sing N N 73  
ALA N   H2   sing N N 74  
ALA CA  C    sing N N 75  
ALA CA  CB   sing N N 76  
ALA CA  HA   sing N N 77  
ALA C   O    doub N N 78  
ALA C   OXT  sing N N 79  
ALA CB  HB1  sing N N 80  
ALA CB  HB2  sing N N 81  
ALA CB  HB3  sing N N 82  
ALA OXT HXT  sing N N 83  
ARG N   CA   sing N N 84  
ARG N   H    sing N N 85  
ARG N   H2   sing N N 86  
ARG CA  C    sing N N 87  
ARG CA  CB   sing N N 88  
ARG CA  HA   sing N N 89  
ARG C   O    doub N N 90  
ARG C   OXT  sing N N 91  
ARG CB  CG   sing N N 92  
ARG CB  HB2  sing N N 93  
ARG CB  HB3  sing N N 94  
ARG CG  CD   sing N N 95  
ARG CG  HG2  sing N N 96  
ARG CG  HG3  sing N N 97  
ARG CD  NE   sing N N 98  
ARG CD  HD2  sing N N 99  
ARG CD  HD3  sing N N 100 
ARG NE  CZ   sing N N 101 
ARG NE  HE   sing N N 102 
ARG CZ  NH1  sing N N 103 
ARG CZ  NH2  doub N N 104 
ARG NH1 HH11 sing N N 105 
ARG NH1 HH12 sing N N 106 
ARG NH2 HH21 sing N N 107 
ARG NH2 HH22 sing N N 108 
ARG OXT HXT  sing N N 109 
ASN N   CA   sing N N 110 
ASN N   H    sing N N 111 
ASN N   H2   sing N N 112 
ASN CA  C    sing N N 113 
ASN CA  CB   sing N N 114 
ASN CA  HA   sing N N 115 
ASN C   O    doub N N 116 
ASN C   OXT  sing N N 117 
ASN CB  CG   sing N N 118 
ASN CB  HB2  sing N N 119 
ASN CB  HB3  sing N N 120 
ASN CG  OD1  doub N N 121 
ASN CG  ND2  sing N N 122 
ASN ND2 HD21 sing N N 123 
ASN ND2 HD22 sing N N 124 
ASN OXT HXT  sing N N 125 
ASP N   CA   sing N N 126 
ASP N   H    sing N N 127 
ASP N   H2   sing N N 128 
ASP CA  C    sing N N 129 
ASP CA  CB   sing N N 130 
ASP CA  HA   sing N N 131 
ASP C   O    doub N N 132 
ASP C   OXT  sing N N 133 
ASP CB  CG   sing N N 134 
ASP CB  HB2  sing N N 135 
ASP CB  HB3  sing N N 136 
ASP CG  OD1  doub N N 137 
ASP CG  OD2  sing N N 138 
ASP OD2 HD2  sing N N 139 
ASP OXT HXT  sing N N 140 
CYS N   CA   sing N N 141 
CYS N   H    sing N N 142 
CYS N   H2   sing N N 143 
CYS CA  C    sing N N 144 
CYS CA  CB   sing N N 145 
CYS CA  HA   sing N N 146 
CYS C   O    doub N N 147 
CYS C   OXT  sing N N 148 
CYS CB  SG   sing N N 149 
CYS CB  HB2  sing N N 150 
CYS CB  HB3  sing N N 151 
CYS SG  HG   sing N N 152 
CYS OXT HXT  sing N N 153 
GLN N   CA   sing N N 154 
GLN N   H    sing N N 155 
GLN N   H2   sing N N 156 
GLN CA  C    sing N N 157 
GLN CA  CB   sing N N 158 
GLN CA  HA   sing N N 159 
GLN C   O    doub N N 160 
GLN C   OXT  sing N N 161 
GLN CB  CG   sing N N 162 
GLN CB  HB2  sing N N 163 
GLN CB  HB3  sing N N 164 
GLN CG  CD   sing N N 165 
GLN CG  HG2  sing N N 166 
GLN CG  HG3  sing N N 167 
GLN CD  OE1  doub N N 168 
GLN CD  NE2  sing N N 169 
GLN NE2 HE21 sing N N 170 
GLN NE2 HE22 sing N N 171 
GLN OXT HXT  sing N N 172 
GLU N   CA   sing N N 173 
GLU N   H    sing N N 174 
GLU N   H2   sing N N 175 
GLU CA  C    sing N N 176 
GLU CA  CB   sing N N 177 
GLU CA  HA   sing N N 178 
GLU C   O    doub N N 179 
GLU C   OXT  sing N N 180 
GLU CB  CG   sing N N 181 
GLU CB  HB2  sing N N 182 
GLU CB  HB3  sing N N 183 
GLU CG  CD   sing N N 184 
GLU CG  HG2  sing N N 185 
GLU CG  HG3  sing N N 186 
GLU CD  OE1  doub N N 187 
GLU CD  OE2  sing N N 188 
GLU OE2 HE2  sing N N 189 
GLU OXT HXT  sing N N 190 
GLY N   CA   sing N N 191 
GLY N   H    sing N N 192 
GLY N   H2   sing N N 193 
GLY CA  C    sing N N 194 
GLY CA  HA2  sing N N 195 
GLY CA  HA3  sing N N 196 
GLY C   O    doub N N 197 
GLY C   OXT  sing N N 198 
GLY OXT HXT  sing N N 199 
HIS N   CA   sing N N 200 
HIS N   H    sing N N 201 
HIS N   H2   sing N N 202 
HIS CA  C    sing N N 203 
HIS CA  CB   sing N N 204 
HIS CA  HA   sing N N 205 
HIS C   O    doub N N 206 
HIS C   OXT  sing N N 207 
HIS CB  CG   sing N N 208 
HIS CB  HB2  sing N N 209 
HIS CB  HB3  sing N N 210 
HIS CG  ND1  sing Y N 211 
HIS CG  CD2  doub Y N 212 
HIS ND1 CE1  doub Y N 213 
HIS ND1 HD1  sing N N 214 
HIS CD2 NE2  sing Y N 215 
HIS CD2 HD2  sing N N 216 
HIS CE1 NE2  sing Y N 217 
HIS CE1 HE1  sing N N 218 
HIS NE2 HE2  sing N N 219 
HIS OXT HXT  sing N N 220 
HOH O   H1   sing N N 221 
HOH O   H2   sing N N 222 
ILE N   CA   sing N N 223 
ILE N   H    sing N N 224 
ILE N   H2   sing N N 225 
ILE CA  C    sing N N 226 
ILE CA  CB   sing N N 227 
ILE CA  HA   sing N N 228 
ILE C   O    doub N N 229 
ILE C   OXT  sing N N 230 
ILE CB  CG1  sing N N 231 
ILE CB  CG2  sing N N 232 
ILE CB  HB   sing N N 233 
ILE CG1 CD1  sing N N 234 
ILE CG1 HG12 sing N N 235 
ILE CG1 HG13 sing N N 236 
ILE CG2 HG21 sing N N 237 
ILE CG2 HG22 sing N N 238 
ILE CG2 HG23 sing N N 239 
ILE CD1 HD11 sing N N 240 
ILE CD1 HD12 sing N N 241 
ILE CD1 HD13 sing N N 242 
ILE OXT HXT  sing N N 243 
LEU N   CA   sing N N 244 
LEU N   H    sing N N 245 
LEU N   H2   sing N N 246 
LEU CA  C    sing N N 247 
LEU CA  CB   sing N N 248 
LEU CA  HA   sing N N 249 
LEU C   O    doub N N 250 
LEU C   OXT  sing N N 251 
LEU CB  CG   sing N N 252 
LEU CB  HB2  sing N N 253 
LEU CB  HB3  sing N N 254 
LEU CG  CD1  sing N N 255 
LEU CG  CD2  sing N N 256 
LEU CG  HG   sing N N 257 
LEU CD1 HD11 sing N N 258 
LEU CD1 HD12 sing N N 259 
LEU CD1 HD13 sing N N 260 
LEU CD2 HD21 sing N N 261 
LEU CD2 HD22 sing N N 262 
LEU CD2 HD23 sing N N 263 
LEU OXT HXT  sing N N 264 
LYS N   CA   sing N N 265 
LYS N   H    sing N N 266 
LYS N   H2   sing N N 267 
LYS CA  C    sing N N 268 
LYS CA  CB   sing N N 269 
LYS CA  HA   sing N N 270 
LYS C   O    doub N N 271 
LYS C   OXT  sing N N 272 
LYS CB  CG   sing N N 273 
LYS CB  HB2  sing N N 274 
LYS CB  HB3  sing N N 275 
LYS CG  CD   sing N N 276 
LYS CG  HG2  sing N N 277 
LYS CG  HG3  sing N N 278 
LYS CD  CE   sing N N 279 
LYS CD  HD2  sing N N 280 
LYS CD  HD3  sing N N 281 
LYS CE  NZ   sing N N 282 
LYS CE  HE2  sing N N 283 
LYS CE  HE3  sing N N 284 
LYS NZ  HZ1  sing N N 285 
LYS NZ  HZ2  sing N N 286 
LYS NZ  HZ3  sing N N 287 
LYS OXT HXT  sing N N 288 
MET N   CA   sing N N 289 
MET N   H    sing N N 290 
MET N   H2   sing N N 291 
MET CA  C    sing N N 292 
MET CA  CB   sing N N 293 
MET CA  HA   sing N N 294 
MET C   O    doub N N 295 
MET C   OXT  sing N N 296 
MET CB  CG   sing N N 297 
MET CB  HB2  sing N N 298 
MET CB  HB3  sing N N 299 
MET CG  SD   sing N N 300 
MET CG  HG2  sing N N 301 
MET CG  HG3  sing N N 302 
MET SD  CE   sing N N 303 
MET CE  HE1  sing N N 304 
MET CE  HE2  sing N N 305 
MET CE  HE3  sing N N 306 
MET OXT HXT  sing N N 307 
PHE N   CA   sing N N 308 
PHE N   H    sing N N 309 
PHE N   H2   sing N N 310 
PHE CA  C    sing N N 311 
PHE CA  CB   sing N N 312 
PHE CA  HA   sing N N 313 
PHE C   O    doub N N 314 
PHE C   OXT  sing N N 315 
PHE CB  CG   sing N N 316 
PHE CB  HB2  sing N N 317 
PHE CB  HB3  sing N N 318 
PHE CG  CD1  doub Y N 319 
PHE CG  CD2  sing Y N 320 
PHE CD1 CE1  sing Y N 321 
PHE CD1 HD1  sing N N 322 
PHE CD2 CE2  doub Y N 323 
PHE CD2 HD2  sing N N 324 
PHE CE1 CZ   doub Y N 325 
PHE CE1 HE1  sing N N 326 
PHE CE2 CZ   sing Y N 327 
PHE CE2 HE2  sing N N 328 
PHE CZ  HZ   sing N N 329 
PHE OXT HXT  sing N N 330 
PRO N   CA   sing N N 331 
PRO N   CD   sing N N 332 
PRO N   H    sing N N 333 
PRO CA  C    sing N N 334 
PRO CA  CB   sing N N 335 
PRO CA  HA   sing N N 336 
PRO C   O    doub N N 337 
PRO C   OXT  sing N N 338 
PRO CB  CG   sing N N 339 
PRO CB  HB2  sing N N 340 
PRO CB  HB3  sing N N 341 
PRO CG  CD   sing N N 342 
PRO CG  HG2  sing N N 343 
PRO CG  HG3  sing N N 344 
PRO CD  HD2  sing N N 345 
PRO CD  HD3  sing N N 346 
PRO OXT HXT  sing N N 347 
SER N   CA   sing N N 348 
SER N   H    sing N N 349 
SER N   H2   sing N N 350 
SER CA  C    sing N N 351 
SER CA  CB   sing N N 352 
SER CA  HA   sing N N 353 
SER C   O    doub N N 354 
SER C   OXT  sing N N 355 
SER CB  OG   sing N N 356 
SER CB  HB2  sing N N 357 
SER CB  HB3  sing N N 358 
SER OG  HG   sing N N 359 
SER OXT HXT  sing N N 360 
THR N   CA   sing N N 361 
THR N   H    sing N N 362 
THR N   H2   sing N N 363 
THR CA  C    sing N N 364 
THR CA  CB   sing N N 365 
THR CA  HA   sing N N 366 
THR C   O    doub N N 367 
THR C   OXT  sing N N 368 
THR CB  OG1  sing N N 369 
THR CB  CG2  sing N N 370 
THR CB  HB   sing N N 371 
THR OG1 HG1  sing N N 372 
THR CG2 HG21 sing N N 373 
THR CG2 HG22 sing N N 374 
THR CG2 HG23 sing N N 375 
THR OXT HXT  sing N N 376 
TRP N   CA   sing N N 377 
TRP N   H    sing N N 378 
TRP N   H2   sing N N 379 
TRP CA  C    sing N N 380 
TRP CA  CB   sing N N 381 
TRP CA  HA   sing N N 382 
TRP C   O    doub N N 383 
TRP C   OXT  sing N N 384 
TRP CB  CG   sing N N 385 
TRP CB  HB2  sing N N 386 
TRP CB  HB3  sing N N 387 
TRP CG  CD1  doub Y N 388 
TRP CG  CD2  sing Y N 389 
TRP CD1 NE1  sing Y N 390 
TRP CD1 HD1  sing N N 391 
TRP CD2 CE2  doub Y N 392 
TRP CD2 CE3  sing Y N 393 
TRP NE1 CE2  sing Y N 394 
TRP NE1 HE1  sing N N 395 
TRP CE2 CZ2  sing Y N 396 
TRP CE3 CZ3  doub Y N 397 
TRP CE3 HE3  sing N N 398 
TRP CZ2 CH2  doub Y N 399 
TRP CZ2 HZ2  sing N N 400 
TRP CZ3 CH2  sing Y N 401 
TRP CZ3 HZ3  sing N N 402 
TRP CH2 HH2  sing N N 403 
TRP OXT HXT  sing N N 404 
TYR N   CA   sing N N 405 
TYR N   H    sing N N 406 
TYR N   H2   sing N N 407 
TYR CA  C    sing N N 408 
TYR CA  CB   sing N N 409 
TYR CA  HA   sing N N 410 
TYR C   O    doub N N 411 
TYR C   OXT  sing N N 412 
TYR CB  CG   sing N N 413 
TYR CB  HB2  sing N N 414 
TYR CB  HB3  sing N N 415 
TYR CG  CD1  doub Y N 416 
TYR CG  CD2  sing Y N 417 
TYR CD1 CE1  sing Y N 418 
TYR CD1 HD1  sing N N 419 
TYR CD2 CE2  doub Y N 420 
TYR CD2 HD2  sing N N 421 
TYR CE1 CZ   doub Y N 422 
TYR CE1 HE1  sing N N 423 
TYR CE2 CZ   sing Y N 424 
TYR CE2 HE2  sing N N 425 
TYR CZ  OH   sing N N 426 
TYR OH  HH   sing N N 427 
TYR OXT HXT  sing N N 428 
VAL N   CA   sing N N 429 
VAL N   H    sing N N 430 
VAL N   H2   sing N N 431 
VAL CA  C    sing N N 432 
VAL CA  CB   sing N N 433 
VAL CA  HA   sing N N 434 
VAL C   O    doub N N 435 
VAL C   OXT  sing N N 436 
VAL CB  CG1  sing N N 437 
VAL CB  CG2  sing N N 438 
VAL CB  HB   sing N N 439 
VAL CG1 HG11 sing N N 440 
VAL CG1 HG12 sing N N 441 
VAL CG1 HG13 sing N N 442 
VAL CG2 HG21 sing N N 443 
VAL CG2 HG22 sing N N 444 
VAL CG2 HG23 sing N N 445 
VAL OXT HXT  sing N N 446 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' 'P30 GM133893' 1 
'Department of Energy (DOE, United States)'                                                'United States' KP1607011      2 
'Other government'                                                                         ?               DE-SC0012704   3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6Y2F 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 2' 
_space_group.name_Hall        'P 2 2ab' 
_space_group.IT_number        18 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9BO7 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.021979 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.015585 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009480 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
F ? ? 4.90428 4.07044 ? ? 12.99538 1.63651  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . SER A 1 1   ? 15.88340  38.61331 -21.58104 1.000 15.60957 ? 1   SER A N   1 
ATOM   2    C CA  . SER A 1 1   ? 15.33099  38.05739 -20.35356 1.000 15.52427 ? 1   SER A CA  1 
ATOM   3    C C   . SER A 1 1   ? 13.80830  38.16776 -20.34998 1.000 16.64044 ? 1   SER A C   1 
ATOM   4    O O   . SER A 1 1   ? 13.20637  38.66720 -21.30651 1.000 14.38025 ? 1   SER A O   1 
ATOM   5    C CB  . SER A 1 1   ? 15.92202  38.76091 -19.12151 1.000 15.78177 ? 1   SER A CB  1 
ATOM   6    O OG  . SER A 1 1   ? 17.31669  38.52885 -19.03907 1.000 26.18082 ? 1   SER A OG  1 
ATOM   7    N N   . GLY A 1 2   ? 13.20343  37.71231 -19.26449 1.000 17.18839 ? 2   GLY A N   1 
ATOM   8    C CA  . GLY A 1 2   ? 11.76873  37.47037 -19.18684 1.000 18.38184 ? 2   GLY A CA  1 
ATOM   9    C C   . GLY A 1 2   ? 11.43312  36.02849 -19.51149 1.000 15.08943 ? 2   GLY A C   1 
ATOM   10   O O   . GLY A 1 2   ? 12.12814  35.34854 -20.26267 1.000 19.14437 ? 2   GLY A O   1 
ATOM   11   N N   . PHE A 1 3   ? 10.35133  35.53719 -18.91417 1.000 16.73723 ? 3   PHE A N   1 
ATOM   12   C CA  . PHE A 1 3   ? 9.91873   34.17273 -19.18738 1.000 16.42450 ? 3   PHE A CA  1 
ATOM   13   C C   . PHE A 1 3   ? 8.40187   34.12540 -19.21270 1.000 16.03348 ? 3   PHE A C   1 
ATOM   14   O O   . PHE A 1 3   ? 7.74921   34.45581 -18.21912 1.000 21.26896 ? 3   PHE A O   1 
ATOM   15   C CB  . PHE A 1 3   ? 10.47557  33.18401 -18.16313 1.000 21.07579 ? 3   PHE A CB  1 
ATOM   16   C CG  . PHE A 1 3   ? 10.52888  31.76842 -18.66918 1.000 17.29022 ? 3   PHE A CG  1 
ATOM   17   C CD1 . PHE A 1 3   ? 11.46279  31.39729 -19.62295 1.000 18.47309 ? 3   PHE A CD1 1 
ATOM   18   C CD2 . PHE A 1 3   ? 9.65015   30.81447 -18.19663 1.000 17.95682 ? 3   PHE A CD2 1 
ATOM   19   C CE1 . PHE A 1 3   ? 11.51240  30.10759 -20.10006 1.000 18.89531 ? 3   PHE A CE1 1 
ATOM   20   C CE2 . PHE A 1 3   ? 9.70060   29.52021 -18.66224 1.000 15.87443 ? 3   PHE A CE2 1 
ATOM   21   C CZ  . PHE A 1 3   ? 10.62981  29.16545 -19.61627 1.000 18.76533 ? 3   PHE A CZ  1 
ATOM   22   N N   . ARG A 1 4   ? 7.85483   33.70291 -20.34265 1.000 15.74826 ? 4   ARG A N   1 
ATOM   23   C CA  . ARG A 1 4   ? 6.42611   33.72798 -20.61008 1.000 13.83803 ? 4   ARG A CA  1 
ATOM   24   C C   . ARG A 1 4   ? 5.96289   32.35889 -21.07871 1.000 13.86469 ? 4   ARG A C   1 
ATOM   25   O O   . ARG A 1 4   ? 6.71604   31.61284 -21.70918 1.000 16.73481 ? 4   ARG A O   1 
ATOM   26   C CB  . ARG A 1 4   ? 6.09253   34.75784 -21.70198 1.000 17.36506 ? 4   ARG A CB  1 
ATOM   27   C CG  . ARG A 1 4   ? 5.97787   36.19309 -21.22781 1.000 22.70183 ? 4   ARG A CG  1 
ATOM   28   C CD  . ARG A 1 4   ? 4.57249   36.44505 -20.71986 1.000 28.67832 ? 4   ARG A CD  1 
ATOM   29   N NE  . ARG A 1 4   ? 4.29237   37.85978 -20.51824 1.000 43.58136 ? 4   ARG A NE  1 
ATOM   30   C CZ  . ARG A 1 4   ? 3.21125   38.31223 -19.90002 1.000 31.33458 ? 4   ARG A CZ  1 
ATOM   31   N NH1 . ARG A 1 4   ? 2.30733   37.48486 -19.40498 1.000 26.96531 ? 4   ARG A NH1 1 
ATOM   32   N NH2 . ARG A 1 4   ? 3.03725   39.62489 -19.76748 1.000 18.32665 ? 4   ARG A NH2 1 
ATOM   33   N N   . LYS A 1 5   ? 4.70883   32.03860 -20.78815 1.000 13.62941 ? 5   LYS A N   1 
ATOM   34   C CA  . LYS A 1 5   ? 4.09325   30.88593 -21.42425 1.000 14.72095 ? 5   LYS A CA  1 
ATOM   35   C C   . LYS A 1 5   ? 3.89968   31.21703 -22.89683 1.000 22.92145 ? 5   LYS A C   1 
ATOM   36   O O   . LYS A 1 5   ? 3.17458   32.15405 -23.24714 1.000 25.85186 ? 5   LYS A O   1 
ATOM   37   C CB  . LYS A 1 5   ? 2.76946   30.53753 -20.75163 1.000 13.83825 ? 5   LYS A CB  1 
ATOM   38   C CG  . LYS A 1 5   ? 2.13190   29.24023 -21.24023 1.000 22.50994 ? 5   LYS A CG  1 
ATOM   39   C CD  . LYS A 1 5   ? 3.01429   28.02478 -20.97748 1.000 18.57882 ? 5   LYS A CD  1 
ATOM   40   C CE  . LYS A 1 5   ? 3.15707   27.72864 -19.49338 1.000 24.38895 ? 5   LYS A CE  1 
ATOM   41   N NZ  . LYS A 1 5   ? 1.83824   27.52959 -18.83374 1.000 23.77805 ? 5   LYS A NZ  1 
ATOM   42   N N   . MET A 1 6   ? 4.58977   30.48554 -23.75258 1.000 14.15486 ? 6   MET A N   1 
ATOM   43   C CA  . MET A 1 6   ? 4.76419   30.85612 -25.14519 1.000 17.65051 ? 6   MET A CA  1 
ATOM   44   C C   . MET A 1 6   ? 4.18800   29.75769 -26.02323 1.000 16.81890 ? 6   MET A C   1 
ATOM   45   O O   . MET A 1 6   ? 4.44719   28.57517 -25.78460 1.000 15.92489 ? 6   MET A O   1 
ATOM   46   C CB  . MET A 1 6   ? 6.25162   31.06328 -25.42914 1.000 19.50917 ? 6   MET A CB  1 
ATOM   47   C CG  . MET A 1 6   ? 6.61829   31.45184 -26.82282 1.000 26.68814 ? 6   MET A CG  1 
ATOM   48   S SD  . MET A 1 6   ? 8.39414   31.76579 -26.82705 1.000 33.84508 ? 6   MET A SD  1 
ATOM   49   C CE  . MET A 1 6   ? 8.50107   33.18114 -25.74336 1.000 22.25521 ? 6   MET A CE  1 
ATOM   50   N N   . ALA A 1 7   ? 3.41055   30.14442 -27.02828 1.000 14.27253 ? 7   ALA A N   1 
ATOM   51   C CA  . ALA A 1 7   ? 2.87776   29.19696 -27.99391 1.000 12.43853 ? 7   ALA A CA  1 
ATOM   52   C C   . ALA A 1 7   ? 3.72387   29.22099 -29.26183 1.000 12.53127 ? 7   ALA A C   1 
ATOM   53   O O   . ALA A 1 7   ? 4.46947   30.16884 -29.51478 1.000 15.23008 ? 7   ALA A O   1 
ATOM   54   C CB  . ALA A 1 7   ? 1.41533   29.51834 -28.31860 1.000 10.95253 ? 7   ALA A CB  1 
ATOM   55   N N   . PHE A 1 8   ? 3.62923   28.14811 -30.04329 1.000 13.26095 ? 8   PHE A N   1 
ATOM   56   C CA  . PHE A 1 8   ? 4.22339   28.16648 -31.36923 1.000 12.84585 ? 8   PHE A CA  1 
ATOM   57   C C   . PHE A 1 8   ? 3.46439   29.13504 -32.27247 1.000 13.97899 ? 8   PHE A C   1 
ATOM   58   O O   . PHE A 1 8   ? 2.25246   29.31955 -32.11658 1.000 15.10113 ? 8   PHE A O   1 
ATOM   59   C CB  . PHE A 1 8   ? 4.20223   26.77920 -32.00409 1.000 14.58746 ? 8   PHE A CB  1 
ATOM   60   C CG  . PHE A 1 8   ? 5.14540   25.79219 -31.37018 1.000 14.22222 ? 8   PHE A CG  1 
ATOM   61   C CD1 . PHE A 1 8   ? 6.48001   25.74464 -31.74082 1.000 19.42833 ? 8   PHE A CD1 1 
ATOM   62   C CD2 . PHE A 1 8   ? 4.68614   24.89174 -30.41909 1.000 17.28424 ? 8   PHE A CD2 1 
ATOM   63   C CE1 . PHE A 1 8   ? 7.34221   24.82161 -31.15584 1.000 18.59243 ? 8   PHE A CE1 1 
ATOM   64   C CE2 . PHE A 1 8   ? 5.53704   23.97666 -29.83869 1.000 22.60623 ? 8   PHE A CE2 1 
ATOM   65   C CZ  . PHE A 1 8   ? 6.86246   23.94283 -30.20547 1.000 18.33259 ? 8   PHE A CZ  1 
ATOM   66   N N   . PRO A 1 9   ? 4.15419   29.75372 -33.23240 1.000 14.71038 ? 9   PRO A N   1 
ATOM   67   C CA  . PRO A 1 9   ? 3.44741   30.51840 -34.26818 1.000 13.62332 ? 9   PRO A CA  1 
ATOM   68   C C   . PRO A 1 9   ? 2.45186   29.61274 -34.97424 1.000 12.96935 ? 9   PRO A C   1 
ATOM   69   O O   . PRO A 1 9   ? 2.77814   28.48351 -35.35762 1.000 15.93091 ? 9   PRO A O   1 
ATOM   70   C CB  . PRO A 1 9   ? 4.56958   30.97726 -35.20963 1.000 13.73859 ? 9   PRO A CB  1 
ATOM   71   C CG  . PRO A 1 9   ? 5.83323   30.83391 -34.40648 1.000 19.04673 ? 9   PRO A CG  1 
ATOM   72   C CD  . PRO A 1 9   ? 5.60662   29.69866 -33.46113 1.000 18.05629 ? 9   PRO A CD  1 
ATOM   73   N N   . SER A 1 10  ? 1.23862   30.11968 -35.15381 1.000 11.80438 ? 10  SER A N   1 
ATOM   74   C CA  . SER A 1 10  ? 0.11981   29.29645 -35.59176 1.000 10.36869 ? 10  SER A CA  1 
ATOM   75   C C   . SER A 1 10  ? -0.12943  29.34451 -37.09089 1.000 14.79618 ? 10  SER A C   1 
ATOM   76   O O   . SER A 1 10  ? -0.99292  28.61204 -37.57312 1.000 14.77482 ? 10  SER A O   1 
ATOM   77   C CB  . SER A 1 10  ? -1.15770  29.70379 -34.84645 1.000 13.38036 ? 10  SER A CB  1 
ATOM   78   O OG  . SER A 1 10  ? -1.46037  31.07258 -35.03067 1.000 13.41231 ? 10  SER A OG  1 
ATOM   79   N N   . GLY A 1 11  ? 0.62035   30.15279 -37.83842 1.000 16.13390 ? 11  GLY A N   1 
ATOM   80   C CA  . GLY A 1 11  ? 0.28898   30.37121 -39.24160 1.000 13.37551 ? 11  GLY A CA  1 
ATOM   81   C C   . GLY A 1 11  ? 0.21077   29.10103 -40.06796 1.000 14.35476 ? 11  GLY A C   1 
ATOM   82   O O   . GLY A 1 11  ? -0.69679  28.94796 -40.88802 1.000 15.30500 ? 11  GLY A O   1 
ATOM   83   N N   . LYS A 1 12  ? 1.17269   28.18930 -39.89019 1.000 14.93451 ? 12  LYS A N   1 
ATOM   84   C CA  . LYS A 1 12  ? 1.18851   26.97129 -40.69794 1.000 14.78780 ? 12  LYS A CA  1 
ATOM   85   C C   . LYS A 1 12  ? -0.07606  26.15444 -40.49162 1.000 19.40781 ? 12  LYS A C   1 
ATOM   86   O O   . LYS A 1 12  ? -0.55240  25.49801 -41.42663 1.000 15.56487 ? 12  LYS A O   1 
ATOM   87   C CB  . LYS A 1 12  ? 2.41845   26.12015 -40.36388 1.000 13.22993 ? 12  LYS A CB  1 
ATOM   88   C CG  . LYS A 1 12  ? 3.73005   26.63650 -40.95356 1.000 16.20221 ? 12  LYS A CG  1 
ATOM   89   C CD  . LYS A 1 12  ? 4.91013   25.81451 -40.47408 1.000 22.79195 ? 12  LYS A CD  1 
ATOM   90   C CE  . LYS A 1 12  ? 6.22190   26.34905 -41.02657 1.000 27.08607 ? 12  LYS A CE  1 
ATOM   91   N NZ  . LYS A 1 12  ? 6.28176   26.26376 -42.50335 1.000 34.91448 ? 12  LYS A NZ  1 
ATOM   92   N N   . VAL A 1 13  ? -0.62054  26.17506 -39.27476 1.000 13.41165 ? 13  VAL A N   1 
ATOM   93   C CA  . VAL A 1 13  ? -1.83826  25.43246 -38.96024 1.000 11.80202 ? 13  VAL A CA  1 
ATOM   94   C C   . VAL A 1 13  ? -3.07604  26.19843 -39.41083 1.000 15.44167 ? 13  VAL A C   1 
ATOM   95   O O   . VAL A 1 13  ? -4.05563  25.60004 -39.86917 1.000 13.23028 ? 13  VAL A O   1 
ATOM   96   C CB  . VAL A 1 13  ? -1.87922  25.12688 -37.45257 1.000 11.24100 ? 13  VAL A CB  1 
ATOM   97   C CG1 . VAL A 1 13  ? -3.17220  24.39581 -37.09451 1.000 10.66608 ? 13  VAL A CG1 1 
ATOM   98   C CG2 . VAL A 1 13  ? -0.64439  24.32046 -37.04090 1.000 15.26904 ? 13  VAL A CG2 1 
ATOM   99   N N   . GLU A 1 14  ? -3.06817  27.52744 -39.26880 1.000 11.32516 ? 14  GLU A N   1 
ATOM   100  C CA  . GLU A 1 14  ? -4.19779  28.32818 -39.73252 1.000 13.02187 ? 14  GLU A CA  1 
ATOM   101  C C   . GLU A 1 14  ? -4.51832  28.02442 -41.18500 1.000 12.74276 ? 14  GLU A C   1 
ATOM   102  O O   . GLU A 1 14  ? -5.69243  27.92961 -41.56280 1.000 13.46210 ? 14  GLU A O   1 
ATOM   103  C CB  . GLU A 1 14  ? -3.90290  29.82164 -39.56835 1.000 13.30516 ? 14  GLU A CB  1 
ATOM   104  C CG  . GLU A 1 14  ? -3.78599  30.27938 -38.13604 1.000 14.35414 ? 14  GLU A CG  1 
ATOM   105  C CD  . GLU A 1 14  ? -3.27638  31.69823 -38.04475 1.000 16.16918 ? 14  GLU A CD  1 
ATOM   106  O OE1 . GLU A 1 14  ? -3.84856  32.56529 -38.73658 1.000 17.32276 ? 14  GLU A OE1 1 
ATOM   107  O OE2 . GLU A 1 14  ? -2.29441  31.93787 -37.30475 1.000 16.84260 ? 14  GLU A OE2 1 
ATOM   108  N N   . GLY A 1 15  ? -3.48156  27.85760 -42.00679 1.000 14.44576 ? 15  GLY A N   1 
ATOM   109  C CA  . GLY A 1 15  ? -3.65653  27.57216 -43.41974 1.000 13.79100 ? 15  GLY A CA  1 
ATOM   110  C C   . GLY A 1 15  ? -4.28706  26.22874 -43.71315 1.000 14.63546 ? 15  GLY A C   1 
ATOM   111  O O   . GLY A 1 15  ? -4.57999  25.95227 -44.88012 1.000 16.12261 ? 15  GLY A O   1 
ATOM   112  N N   . CYS A 1 16  ? -4.50753  25.39794 -42.69219 1.000 11.56829 ? 16  CYS A N   1 
ATOM   113  C CA  . CYS A 1 16  ? -5.10685  24.08228 -42.87017 1.000 13.07913 ? 16  CYS A CA  1 
ATOM   114  C C   . CYS A 1 16  ? -6.50998  23.97070 -42.29302 1.000 12.04148 ? 16  CYS A C   1 
ATOM   115  O O   . CYS A 1 16  ? -7.12279  22.91077 -42.41439 1.000 14.44820 ? 16  CYS A O   1 
ATOM   116  C CB  . CYS A 1 16  ? -4.23610  22.99891 -42.23368 1.000 11.29216 ? 16  CYS A CB  1 
ATOM   117  S SG  . CYS A 1 16  ? -2.53582  22.97105 -42.82081 1.000 16.27832 ? 16  CYS A SG  1 
ATOM   118  N N   . MET A 1 17  ? -7.03344  25.00979 -41.65241 1.000 11.21883 ? 17  MET A N   1 
ATOM   119  C CA  . MET A 1 17  ? -8.31573  24.86816 -40.97566 1.000 10.84592 ? 17  MET A CA  1 
ATOM   120  C C   . MET A 1 17  ? -9.47542  25.05960 -41.93817 1.000 14.48605 ? 17  MET A C   1 
ATOM   121  O O   . MET A 1 17  ? -9.47569  25.97923 -42.76214 1.000 14.17419 ? 17  MET A O   1 
ATOM   122  C CB  . MET A 1 17  ? -8.43199  25.86211 -39.82204 1.000 10.42691 ? 17  MET A CB  1 
ATOM   123  C CG  . MET A 1 17  ? -7.36373  25.66417 -38.74316 1.000 12.48058 ? 17  MET A CG  1 
ATOM   124  S SD  . MET A 1 17  ? -7.23968  23.96588 -38.12902 1.000 14.03650 ? 17  MET A SD  1 
ATOM   125  C CE  . MET A 1 17  ? -8.90729  23.68417 -37.52402 1.000 16.29244 ? 17  MET A CE  1 
ATOM   126  N N   . VAL A 1 18  ? -10.46196 24.17253 -41.83551 1.000 13.74898 ? 18  VAL A N   1 
ATOM   127  C CA  . VAL A 1 18  ? -11.66718 24.24044 -42.65005 1.000 10.56579 ? 18  VAL A CA  1 
ATOM   128  C C   . VAL A 1 18  ? -12.87033 23.97193 -41.75609 1.000 13.29448 ? 18  VAL A C   1 
ATOM   129  O O   . VAL A 1 18  ? -12.74233 23.57270 -40.59551 1.000 12.78908 ? 18  VAL A O   1 
ATOM   130  C CB  . VAL A 1 18  ? -11.64473 23.24600 -43.83494 1.000 12.64936 ? 18  VAL A CB  1 
ATOM   131  C CG1 . VAL A 1 18  ? -10.44768 23.52919 -44.75088 1.000 16.42530 ? 18  VAL A CG1 1 
ATOM   132  C CG2 . VAL A 1 18  ? -11.59932 21.82236 -43.33209 1.000 14.03443 ? 18  VAL A CG2 1 
ATOM   133  N N   . GLN A 1 19  ? -14.04794 24.20019 -42.32345 1.000 13.94236 ? 19  GLN A N   1 
ATOM   134  C CA  . GLN A 1 19  ? -15.32253 23.94751 -41.67774 1.000 13.14969 ? 19  GLN A CA  1 
ATOM   135  C C   . GLN A 1 19  ? -15.93345 22.68747 -42.27834 1.000 14.23186 ? 19  GLN A C   1 
ATOM   136  O O   . GLN A 1 19  ? -15.91178 22.50535 -43.49850 1.000 16.64721 ? 19  GLN A O   1 
ATOM   137  C CB  . GLN A 1 19  ? -16.25584 25.15170 -41.87699 1.000 14.59043 ? 19  GLN A CB  1 
ATOM   138  C CG  . GLN A 1 19  ? -17.54770 25.12121 -41.11188 1.000 24.04694 ? 19  GLN A CG  1 
ATOM   139  C CD  . GLN A 1 19  ? -18.35345 26.39060 -41.33150 1.000 20.36258 ? 19  GLN A CD  1 
ATOM   140  O OE1 . GLN A 1 19  ? -19.24272 26.71560 -40.55310 1.000 39.65574 ? 19  GLN A OE1 1 
ATOM   141  N NE2 . GLN A 1 19  ? -18.02860 27.12223 -42.39885 1.000 30.24299 ? 19  GLN A NE2 1 
ATOM   142  N N   . VAL A 1 20  ? -16.45295 21.80293 -41.42870 1.000 12.41735 ? 20  VAL A N   1 
ATOM   143  C CA  . VAL A 1 20  ? -17.11674 20.58279 -41.88425 1.000 16.74330 ? 20  VAL A CA  1 
ATOM   144  C C   . VAL A 1 20  ? -18.53009 20.56041 -41.32681 1.000 17.43495 ? 20  VAL A C   1 
ATOM   145  O O   . VAL A 1 20  ? -18.72165 20.63250 -40.10695 1.000 17.31037 ? 20  VAL A O   1 
ATOM   146  C CB  . VAL A 1 20  ? -16.35517 19.31727 -41.46217 1.000 18.25466 ? 20  VAL A CB  1 
ATOM   147  C CG1 . VAL A 1 20  ? -17.06081 18.06782 -41.99310 1.000 15.19765 ? 20  VAL A CG1 1 
ATOM   148  C CG2 . VAL A 1 20  ? -14.91639 19.37760 -41.94981 1.000 15.70291 ? 20  VAL A CG2 1 
ATOM   149  N N   . THR A 1 21  ? -19.51605 20.43280 -42.21542 1.000 14.99660 ? 21  THR A N   1 
ATOM   150  C CA  . THR A 1 21  ? -20.92136 20.36652 -41.83093 1.000 19.56052 ? 21  THR A CA  1 
ATOM   151  C C   . THR A 1 21  ? -21.53275 19.08759 -42.37723 1.000 18.14912 ? 21  THR A C   1 
ATOM   152  O O   . THR A 1 21  ? -21.36511 18.76983 -43.55989 1.000 18.09992 ? 21  THR A O   1 
ATOM   153  C CB  . THR A 1 21  ? -21.70939 21.56882 -42.35565 1.000 16.29282 ? 21  THR A CB  1 
ATOM   154  O OG1 . THR A 1 21  ? -21.16095 22.77966 -41.82350 1.000 18.92223 ? 21  THR A OG1 1 
ATOM   155  C CG2 . THR A 1 21  ? -23.17249 21.46018 -41.95772 1.000 21.54733 ? 21  THR A CG2 1 
ATOM   156  N N   . CYS A 1 22  ? -22.23495 18.35859 -41.51478 1.000 16.82227 ? 22  CYS A N   1 
ATOM   157  C CA  . CYS A 1 22  ? -23.03465 17.21105 -41.92141 1.000 20.89892 ? 22  CYS A CA  1 
ATOM   158  C C   . CYS A 1 22  ? -24.40893 17.37509 -41.29810 1.000 22.69534 ? 22  CYS A C   1 
ATOM   159  O O   . CYS A 1 22  ? -24.53374 17.40175 -40.06890 1.000 22.43902 ? 22  CYS A O   1 
ATOM   160  C CB  . CYS A 1 22  ? -22.38194 15.89821 -41.48013 1.000 20.69365 ? 22  CYS A CB  1 
ATOM   161  S SG  . CYS A 1 22  ? -23.14131 14.42238 -42.18611 1.000 29.01366 ? 22  CYS A SG  1 
ATOM   162  N N   . GLY A 1 23  ? -25.42954 17.51922 -42.13340 1.000 26.11308 ? 23  GLY A N   1 
ATOM   163  C CA  . GLY A 1 23  ? -26.74845 17.84404 -41.60092 1.000 18.96076 ? 23  GLY A CA  1 
ATOM   164  C C   . GLY A 1 23  ? -26.72282 19.24107 -40.99930 1.000 22.68784 ? 23  GLY A C   1 
ATOM   165  O O   . GLY A 1 23  ? -26.42758 20.24149 -41.67002 1.000 30.74155 ? 23  GLY A O   1 
ATOM   166  N N   . THR A 1 24  ? -27.03251 19.32988 -39.70742 1.000 21.62643 ? 24  THR A N   1 
ATOM   167  C CA  . THR A 1 24  ? -26.98359 20.59154 -38.98028 1.000 22.88788 ? 24  THR A CA  1 
ATOM   168  C C   . THR A 1 24  ? -25.80069 20.67118 -38.02785 1.000 24.07648 ? 24  THR A C   1 
ATOM   169  O O   . THR A 1 24  ? -25.65196 21.67847 -37.32770 1.000 27.60756 ? 24  THR A O   1 
ATOM   170  C CB  . THR A 1 24  ? -28.28795 20.82522 -38.20108 1.000 31.39262 ? 24  THR A CB  1 
ATOM   171  O OG1 . THR A 1 24  ? -28.60960 19.66234 -37.42672 1.000 31.09046 ? 24  THR A OG1 1 
ATOM   172  C CG2 . THR A 1 24  ? -29.42679 21.12485 -39.15694 1.000 32.96492 ? 24  THR A CG2 1 
ATOM   173  N N   . THR A 1 25  ? -24.95998 19.64009 -37.98328 1.000 22.28456 ? 25  THR A N   1 
ATOM   174  C CA  . THR A 1 25  ? -23.79316 19.62046 -37.11422 1.000 20.41348 ? 25  THR A CA  1 
ATOM   175  C C   . THR A 1 25  ? -22.59050 20.18421 -37.86132 1.000 18.54508 ? 25  THR A C   1 
ATOM   176  O O   . THR A 1 25  ? -22.27460 19.73471 -38.96683 1.000 19.19168 ? 25  THR A O   1 
ATOM   177  C CB  . THR A 1 25  ? -23.50084 18.19504 -36.64410 1.000 20.90515 ? 25  THR A CB  1 
ATOM   178  O OG1 . THR A 1 25  ? -24.67231 17.64335 -36.02656 1.000 28.20780 ? 25  THR A OG1 1 
ATOM   179  C CG2 . THR A 1 25  ? -22.35054 18.17857 -35.63955 1.000 22.29210 ? 25  THR A CG2 1 
ATOM   180  N N   . THR A 1 26  ? -21.93208 21.17492 -37.26095 1.000 18.47854 ? 26  THR A N   1 
ATOM   181  C CA  . THR A 1 26  ? -20.75312 21.79575 -37.84740 1.000 16.41850 ? 26  THR A CA  1 
ATOM   182  C C   . THR A 1 26  ? -19.61541 21.76282 -36.84210 1.000 21.76852 ? 26  THR A C   1 
ATOM   183  O O   . THR A 1 26  ? -19.83138 21.96311 -35.64489 1.000 21.59309 ? 26  THR A O   1 
ATOM   184  C CB  . THR A 1 26  ? -21.02432 23.24076 -38.27056 1.000 23.64524 ? 26  THR A CB  1 
ATOM   185  O OG1 . THR A 1 26  ? -21.96994 23.25327 -39.34596 1.000 25.41108 ? 26  THR A OG1 1 
ATOM   186  C CG2 . THR A 1 26  ? -19.75238 23.90558 -38.74000 1.000 22.00764 ? 26  THR A CG2 1 
ATOM   187  N N   . LEU A 1 27  ? -18.40881 21.49092 -37.33101 1.000 14.83025 ? 27  LEU A N   1 
ATOM   188  C CA  . LEU A 1 27  ? -17.20821 21.57463 -36.50208 1.000 13.90993 ? 27  LEU A CA  1 
ATOM   189  C C   . LEU A 1 27  ? -16.02534 21.84684 -37.42936 1.000 14.05198 ? 27  LEU A C   1 
ATOM   190  O O   . LEU A 1 27  ? -16.20336 22.07937 -38.62588 1.000 13.96015 ? 27  LEU A O   1 
ATOM   191  C CB  . LEU A 1 27  ? -17.04108 20.31305 -35.64446 1.000 17.73037 ? 27  LEU A CB  1 
ATOM   192  C CG  . LEU A 1 27  ? -17.25371 18.92178 -36.23443 1.000 19.57914 ? 27  LEU A CG  1 
ATOM   193  C CD1 . LEU A 1 27  ? -16.32966 18.68030 -37.42427 1.000 18.48616 ? 27  LEU A CD1 1 
ATOM   194  C CD2 . LEU A 1 27  ? -17.04607 17.85163 -35.15906 1.000 15.92299 ? 27  LEU A CD2 1 
ATOM   195  N N   . ASN A 1 28  ? -14.81601 21.84100 -36.87302 1.000 12.35800 ? 28  ASN A N   1 
ATOM   196  C CA  . ASN A 1 28  ? -13.61147 22.14459 -37.62968 1.000 12.04629 ? 28  ASN A CA  1 
ATOM   197  C C   . ASN A 1 28  ? -12.96373 20.89147 -38.21201 1.000 12.34757 ? 28  ASN A C   1 
ATOM   198  O O   . ASN A 1 28  ? -13.03083 19.79907 -37.63961 1.000 12.79822 ? 28  ASN A O   1 
ATOM   199  C CB  . ASN A 1 28  ? -12.59610 22.85671 -36.73574 1.000 12.39992 ? 28  ASN A CB  1 
ATOM   200  C CG  . ASN A 1 28  ? -13.18548 24.05535 -36.04708 1.000 14.88929 ? 28  ASN A CG  1 
ATOM   201  O OD1 . ASN A 1 28  ? -13.36892 25.09961 -36.66191 1.000 15.27938 ? 28  ASN A OD1 1 
ATOM   202  N ND2 . ASN A 1 28  ? -13.47720 23.91797 -34.74679 1.000 14.81621 ? 28  ASN A ND2 1 
ATOM   203  N N   . GLY A 1 29  ? -12.31392 21.06673 -39.36256 1.000 11.99391 ? 29  GLY A N   1 
ATOM   204  C CA  . GLY A 1 29  ? -11.48663 20.02712 -39.92553 1.000 11.79930 ? 29  GLY A CA  1 
ATOM   205  C C   . GLY A 1 29  ? -10.09712 20.53111 -40.25139 1.000 13.67850 ? 29  GLY A C   1 
ATOM   206  O O   . GLY A 1 29  ? -9.83951  21.73010 -40.33441 1.000 13.29554 ? 29  GLY A O   1 
ATOM   207  N N   . LEU A 1 30  ? -9.20157  19.57458 -40.46261 1.000 12.89183 ? 30  LEU A N   1 
ATOM   208  C CA  . LEU A 1 30  ? -7.80431  19.83212 -40.77989 1.000 13.28345 ? 30  LEU A CA  1 
ATOM   209  C C   . LEU A 1 30  ? -7.53409  19.31181 -42.18262 1.000 13.03323 ? 30  LEU A C   1 
ATOM   210  O O   . LEU A 1 30  ? -7.65902  18.10622 -42.43248 1.000 13.17766 ? 30  LEU A O   1 
ATOM   211  C CB  . LEU A 1 30  ? -6.88881  19.15042 -39.76918 1.000 12.47439 ? 30  LEU A CB  1 
ATOM   212  C CG  . LEU A 1 30  ? -5.39946  19.47308 -39.89920 1.000 14.85857 ? 30  LEU A CG  1 
ATOM   213  C CD1 . LEU A 1 30  ? -5.14375  20.89141 -39.41669 1.000 11.76872 ? 30  LEU A CD1 1 
ATOM   214  C CD2 . LEU A 1 30  ? -4.55372  18.45134 -39.15237 1.000 13.95632 ? 30  LEU A CD2 1 
ATOM   215  N N   . TRP A 1 31  ? -7.16578  20.22058 -43.08299 1.000 14.60536 ? 31  TRP A N   1 
ATOM   216  C CA  . TRP A 1 31  ? -7.01936  19.94355 -44.50924 1.000 13.23518 ? 31  TRP A CA  1 
ATOM   217  C C   . TRP A 1 31  ? -5.53308  19.82005 -44.84683 1.000 11.98578 ? 31  TRP A C   1 
ATOM   218  O O   . TRP A 1 31  ? -4.81212  20.82250 -44.87913 1.000 11.91691 ? 31  TRP A O   1 
ATOM   219  C CB  . TRP A 1 31  ? -7.68872  21.06701 -45.30395 1.000 11.05603 ? 31  TRP A CB  1 
ATOM   220  C CG  . TRP A 1 31  ? -7.67747  20.93266 -46.81971 1.000 12.26249 ? 31  TRP A CG  1 
ATOM   221  C CD1 . TRP A 1 31  ? -7.54245  19.78757 -47.54543 1.000 13.61310 ? 31  TRP A CD1 1 
ATOM   222  C CD2 . TRP A 1 31  ? -7.82593  21.99672 -47.76886 1.000 13.83060 ? 31  TRP A CD2 1 
ATOM   223  N NE1 . TRP A 1 31  ? -7.60099  20.07284 -48.89401 1.000 15.51690 ? 31  TRP A NE1 1 
ATOM   224  C CE2 . TRP A 1 31  ? -7.77398  21.42186 -49.05268 1.000 12.32070 ? 31  TRP A CE2 1 
ATOM   225  C CE3 . TRP A 1 31  ? -7.99525  23.38327 -47.65627 1.000 12.73583 ? 31  TRP A CE3 1 
ATOM   226  C CZ2 . TRP A 1 31  ? -7.88303  22.18105 -50.21069 1.000 12.76848 ? 31  TRP A CZ2 1 
ATOM   227  C CZ3 . TRP A 1 31  ? -8.09987  24.13478 -48.80531 1.000 20.93797 ? 31  TRP A CZ3 1 
ATOM   228  C CH2 . TRP A 1 31  ? -8.04440  23.53414 -50.06621 1.000 15.47528 ? 31  TRP A CH2 1 
ATOM   229  N N   . LEU A 1 32  ? -5.07024  18.58957 -45.07907 1.000 11.28789 ? 32  LEU A N   1 
ATOM   230  C CA  . LEU A 1 32  ? -3.67399  18.31494 -45.41402 1.000 11.20284 ? 32  LEU A CA  1 
ATOM   231  C C   . LEU A 1 32  ? -3.63943  17.55922 -46.73138 1.000 14.42865 ? 32  LEU A C   1 
ATOM   232  O O   . LEU A 1 32  ? -4.24978  16.49347 -46.84895 1.000 13.49159 ? 32  LEU A O   1 
ATOM   233  C CB  . LEU A 1 32  ? -2.99079  17.49002 -44.31723 1.000 10.93618 ? 32  LEU A CB  1 
ATOM   234  C CG  . LEU A 1 32  ? -2.97660  18.09399 -42.90812 1.000 14.11862 ? 32  LEU A CG  1 
ATOM   235  C CD1 . LEU A 1 32  ? -2.44122  17.08662 -41.89614 1.000 12.21565 ? 32  LEU A CD1 1 
ATOM   236  C CD2 . LEU A 1 32  ? -2.14591  19.37151 -42.88190 1.000 18.70586 ? 32  LEU A CD2 1 
ATOM   237  N N   . ASP A 1 33  ? -2.91583  18.09414 -47.71305 1.000 16.24869 ? 33  ASP A N   1 
ATOM   238  C CA  . ASP A 1 33  ? -2.94552  17.52870 -49.07004 1.000 13.33527 ? 33  ASP A CA  1 
ATOM   239  C C   . ASP A 1 33  ? -4.41523  17.43133 -49.48026 1.000 16.87467 ? 33  ASP A C   1 
ATOM   240  O O   . ASP A 1 33  ? -5.13940  18.42543 -49.33558 1.000 15.22913 ? 33  ASP A O   1 
ATOM   241  C CB  . ASP A 1 33  ? -2.16622  16.22797 -49.08881 1.000 15.16463 ? 33  ASP A CB  1 
ATOM   242  C CG  . ASP A 1 33  ? -0.67567  16.45126 -48.87377 1.000 17.18515 ? 33  ASP A CG  1 
ATOM   243  O OD1 . ASP A 1 33  ? -0.19261  17.52044 -49.29084 1.000 18.59357 ? 33  ASP A OD1 1 
ATOM   244  O OD2 . ASP A 1 33  ? -0.00766  15.57927 -48.27885 1.000 21.94815 ? 33  ASP A OD2 1 
ATOM   245  N N   . ASP A 1 34  ? -4.89155  16.28624 -49.97637 1.000 12.83326 ? 34  ASP A N   1 
ATOM   246  C CA  . ASP A 1 34  ? -6.27442  16.16677 -50.42635 1.000 14.76152 ? 34  ASP A CA  1 
ATOM   247  C C   . ASP A 1 34  ? -7.16558  15.43154 -49.42747 1.000 17.84589 ? 34  ASP A C   1 
ATOM   248  O O   . ASP A 1 34  ? -8.12992  14.77248 -49.83292 1.000 16.11725 ? 34  ASP A O   1 
ATOM   249  C CB  . ASP A 1 34  ? -6.33223  15.48770 -51.79887 1.000 16.93003 ? 34  ASP A CB  1 
ATOM   250  C CG  . ASP A 1 34  ? -5.74828  14.08514 -51.79228 1.000 16.93878 ? 34  ASP A CG  1 
ATOM   251  O OD1 . ASP A 1 34  ? -5.09997  13.69423 -50.80369 1.000 19.93909 ? 34  ASP A OD1 1 
ATOM   252  O OD2 . ASP A 1 34  ? -5.94866  13.35997 -52.79512 1.000 25.37239 ? 34  ASP A OD2 1 
ATOM   253  N N   . VAL A 1 35  ? -6.88474  15.54661 -48.12878 1.000 14.91222 ? 35  VAL A N   1 
ATOM   254  C CA  . VAL A 1 35  ? -7.67052  14.87578 -47.09992 1.000 15.23988 ? 35  VAL A CA  1 
ATOM   255  C C   . VAL A 1 35  ? -8.01497  15.87443 -46.00589 1.000 15.01527 ? 35  VAL A C   1 
ATOM   256  O O   . VAL A 1 35  ? -7.15926  16.65026 -45.57041 1.000 14.46340 ? 35  VAL A O   1 
ATOM   257  C CB  . VAL A 1 35  ? -6.92680  13.66949 -46.49792 1.000 14.87284 ? 35  VAL A CB  1 
ATOM   258  C CG1 . VAL A 1 35  ? -7.78225  13.00141 -45.42864 1.000 15.05467 ? 35  VAL A CG1 1 
ATOM   259  C CG2 . VAL A 1 35  ? -6.54585  12.68131 -47.59836 1.000 17.31509 ? 35  VAL A CG2 1 
ATOM   260  N N   . VAL A 1 36  ? -9.26631  15.83887 -45.55203 1.000 13.17023 ? 36  VAL A N   1 
ATOM   261  C CA  . VAL A 1 36  ? -9.73088  16.61535 -44.40668 1.000 14.39308 ? 36  VAL A CA  1 
ATOM   262  C C   . VAL A 1 36  ? -9.98582  15.64815 -43.25951 1.000 16.18124 ? 36  VAL A C   1 
ATOM   263  O O   . VAL A 1 36  ? -10.69724 14.65293 -43.42786 1.000 14.81183 ? 36  VAL A O   1 
ATOM   264  C CB  . VAL A 1 36  ? -11.00052 17.42128 -44.73492 1.000 13.42623 ? 36  VAL A CB  1 
ATOM   265  C CG1 . VAL A 1 36  ? -11.57726 18.04925 -43.46470 1.000 15.18408 ? 36  VAL A CG1 1 
ATOM   266  C CG2 . VAL A 1 36  ? -10.71377 18.48913 -45.78751 1.000 12.58277 ? 36  VAL A CG2 1 
ATOM   267  N N   . TYR A 1 37  ? -9.38972  15.92952 -42.10331 1.000 11.16765 ? 37  TYR A N   1 
ATOM   268  C CA  . TYR A 1 37  ? -9.53281  15.11734 -40.89952 1.000 10.23163 ? 37  TYR A CA  1 
ATOM   269  C C   . TYR A 1 37  ? -10.42227 15.86539 -39.91760 1.000 12.51930 ? 37  TYR A C   1 
ATOM   270  O O   . TYR A 1 37  ? -10.22759 17.06410 -39.69892 1.000 15.89339 ? 37  TYR A O   1 
ATOM   271  C CB  . TYR A 1 37  ? -8.16829  14.85149 -40.26418 1.000 11.27243 ? 37  TYR A CB  1 
ATOM   272  C CG  . TYR A 1 37  ? -7.15690  14.24007 -41.20008 1.000 13.10114 ? 37  TYR A CG  1 
ATOM   273  C CD1 . TYR A 1 37  ? -6.50214  15.01549 -42.15093 1.000 14.23868 ? 37  TYR A CD1 1 
ATOM   274  C CD2 . TYR A 1 37  ? -6.84481  12.88780 -41.12399 1.000 14.70239 ? 37  TYR A CD2 1 
ATOM   275  C CE1 . TYR A 1 37  ? -5.56844  14.45050 -43.01373 1.000 13.37441 ? 37  TYR A CE1 1 
ATOM   276  C CE2 . TYR A 1 37  ? -5.91906  12.31660 -41.97752 1.000 15.18699 ? 37  TYR A CE2 1 
ATOM   277  C CZ  . TYR A 1 37  ? -5.28778  13.10163 -42.91846 1.000 16.58697 ? 37  TYR A CZ  1 
ATOM   278  O OH  . TYR A 1 37  ? -4.37214  12.53703 -43.77125 1.000 17.27133 ? 37  TYR A OH  1 
ATOM   279  N N   . CYS A 1 38  ? -11.39132 15.17401 -39.32554 1.000 13.16340 ? 38  CYS A N   1 
ATOM   280  C CA  . CYS A 1 38  ? -12.27222 15.84157 -38.37658 1.000 13.09699 ? 38  CYS A CA  1 
ATOM   281  C C   . CYS A 1 38  ? -12.83793 14.80435 -37.41253 1.000 16.21631 ? 38  CYS A C   1 
ATOM   282  O O   . CYS A 1 38  ? -12.74430 13.60021 -37.66410 1.000 14.65865 ? 38  CYS A O   1 
ATOM   283  C CB  . CYS A 1 38  ? -13.40294 16.60445 -39.08426 1.000 14.68483 ? 38  CYS A CB  1 
ATOM   284  S SG  . CYS A 1 38  ? -14.72073 15.57561 -39.83452 1.000 16.33653 ? 38  CYS A SG  1 
ATOM   285  N N   . PRO A 1 39  ? -13.40198 15.24751 -36.28812 1.000 14.68871 ? 39  PRO A N   1 
ATOM   286  C CA  . PRO A 1 39  ? -13.99526 14.28407 -35.34750 1.000 13.38914 ? 39  PRO A CA  1 
ATOM   287  C C   . PRO A 1 39  ? -15.21146 13.61478 -35.95894 1.000 14.55764 ? 39  PRO A C   1 
ATOM   288  O O   . PRO A 1 39  ? -16.01592 14.25368 -36.63714 1.000 14.98276 ? 39  PRO A O   1 
ATOM   289  C CB  . PRO A 1 39  ? -14.38638 15.15204 -34.14248 1.000 15.16411 ? 39  PRO A CB  1 
ATOM   290  C CG  . PRO A 1 39  ? -13.52621 16.39426 -34.27306 1.000 15.48377 ? 39  PRO A CG  1 
ATOM   291  C CD  . PRO A 1 39  ? -13.42732 16.61940 -35.75541 1.000 13.29941 ? 39  PRO A CD  1 
ATOM   292  N N   . ARG A 1 40  ? -15.35900 12.31521 -35.69337 1.000 16.07139 ? 40  ARG A N   1 
ATOM   293  C CA  . ARG A 1 40  ? -16.43440 11.58201 -36.35197 1.000 14.49479 ? 40  ARG A CA  1 
ATOM   294  C C   . ARG A 1 40  ? -17.81574 11.99193 -35.85099 1.000 14.39693 ? 40  ARG A C   1 
ATOM   295  O O   . ARG A 1 40  ? -18.80418 11.78052 -36.56798 1.000 15.68839 ? 40  ARG A O   1 
ATOM   296  C CB  . ARG A 1 40  ? -16.23837 10.07235 -36.18791 1.000 15.99348 ? 40  ARG A CB  1 
ATOM   297  C CG  . ARG A 1 40  ? -16.19250 9.56859  -34.75564 1.000 17.31281 ? 40  ARG A CG  1 
ATOM   298  C CD  . ARG A 1 40  ? -16.04870 8.05436  -34.73593 1.000 12.06124 ? 40  ARG A CD  1 
ATOM   299  N NE  . ARG A 1 40  ? -15.97768 7.50105  -33.38899 1.000 13.82024 ? 40  ARG A NE  1 
ATOM   300  C CZ  . ARG A 1 40  ? -16.03032 6.20402  -33.11440 1.000 15.87508 ? 40  ARG A CZ  1 
ATOM   301  N NH1 . ARG A 1 40  ? -16.11097 5.29496  -34.07782 1.000 19.63221 ? 40  ARG A NH1 1 
ATOM   302  N NH2 . ARG A 1 40  ? -16.01667 5.80805  -31.84492 1.000 16.38621 ? 40  ARG A NH2 1 
ATOM   303  N N   . HIS A 1 41  ? -17.90934 12.61771 -34.65294 1.000 14.98221 ? 41  HIS A N   1 
ATOM   304  C CA  . HIS A 1 41  ? -19.28343 12.92615 -34.21531 1.000 16.79206 ? 41  HIS A CA  1 
ATOM   305  C C   . HIS A 1 41  ? -19.90689 14.09879 -34.98365 1.000 15.87160 ? 41  HIS A C   1 
ATOM   306  O O   . HIS A 1 41  ? -21.02431 14.53179 -34.63589 1.000 17.46005 ? 41  HIS A O   1 
ATOM   307  C CB  . HIS A 1 41  ? -19.32758 13.15959 -32.69248 1.000 12.17430 ? 41  HIS A CB  1 
ATOM   308  C CG  . HIS A 1 41  ? -18.70786 14.44571 -32.22319 1.000 15.55968 ? 41  HIS A CG  1 
ATOM   309  N ND1 . HIS A 1 41  ? -17.49052 14.49258 -31.57780 1.000 17.93232 ? 41  HIS A ND1 1 
ATOM   310  C CD2 . HIS A 1 41  ? -19.16221 15.72066 -32.25131 1.000 14.49753 ? 41  HIS A CD2 1 
ATOM   311  C CE1 . HIS A 1 41  ? -17.21226 15.74214 -31.24599 1.000 15.55233 ? 41  HIS A CE1 1 
ATOM   312  N NE2 . HIS A 1 41  ? -18.20722 16.50889 -31.65134 1.000 17.66435 ? 41  HIS A NE2 1 
ATOM   313  N N   . VAL A 1 42  ? -19.24573 14.60516 -36.03057 1.000 14.02222 ? 42  VAL A N   1 
ATOM   314  C CA  . VAL A 1 42  ? -19.90331 15.51211 -36.96173 1.000 13.17261 ? 42  VAL A CA  1 
ATOM   315  C C   . VAL A 1 42  ? -21.10971 14.84821 -37.61595 1.000 13.90408 ? 42  VAL A C   1 
ATOM   316  O O   . VAL A 1 42  ? -22.03088 15.54479 -38.05273 1.000 18.12713 ? 42  VAL A O   1 
ATOM   317  C CB  . VAL A 1 42  ? -18.90121 16.02215 -38.03055 1.000 12.77508 ? 42  VAL A CB  1 
ATOM   318  C CG1 . VAL A 1 42  ? -18.54551 14.92375 -39.02198 1.000 13.60538 ? 42  VAL A CG1 1 
ATOM   319  C CG2 . VAL A 1 42  ? -19.45436 17.25196 -38.75242 1.000 15.49411 ? 42  VAL A CG2 1 
ATOM   320  N N   . ILE A 1 43  ? -21.12474 13.51149 -37.70368 1.000 18.19906 ? 43  ILE A N   1 
ATOM   321  C CA  . ILE A 1 43  ? -22.24039 12.80907 -38.33727 1.000 19.72126 ? 43  ILE A CA  1 
ATOM   322  C C   . ILE A 1 43  ? -23.38747 12.54834 -37.37597 1.000 23.51114 ? 43  ILE A C   1 
ATOM   323  O O   . ILE A 1 43  ? -24.36886 11.89901 -37.76235 1.000 22.66592 ? 43  ILE A O   1 
ATOM   324  C CB  . ILE A 1 43  ? -21.81775 11.46049 -38.96494 1.000 15.95584 ? 43  ILE A CB  1 
ATOM   325  C CG1 . ILE A 1 43  ? -21.37388 10.46432 -37.89365 1.000 14.90666 ? 43  ILE A CG1 1 
ATOM   326  C CG2 . ILE A 1 43  ? -20.72133 11.66512 -39.99959 1.000 15.52814 ? 43  ILE A CG2 1 
ATOM   327  C CD1 . ILE A 1 43  ? -20.95767 9.12118  -38.46541 1.000 18.42843 ? 43  ILE A CD1 1 
ATOM   328  N N   . CYS A 1 44  ? -23.30242 13.03440 -36.14622 1.000 15.20495 ? 44  CYS A N   1 
ATOM   329  C CA  . CYS A 1 44  ? -24.33771 12.81794 -35.14318 1.000 16.85066 ? 44  CYS A CA  1 
ATOM   330  C C   . CYS A 1 44  ? -25.29325 13.99933 -35.08037 1.000 21.68116 ? 44  CYS A C   1 
ATOM   331  O O   . CYS A 1 44  ? -24.87418 15.15669 -35.15676 1.000 21.87932 ? 44  CYS A O   1 
ATOM   332  C CB  . CYS A 1 44  ? -23.72442 12.61300 -33.75844 1.000 15.70882 ? 44  CYS A CB  1 
ATOM   333  S SG  . CYS A 1 44  ? -22.80332 11.10590 -33.55577 1.000 20.14806 ? 44  CYS A SG  1 
ATOM   334  N N   . THR A 1 45  ? -26.57908 13.70407 -34.92602 1.000 22.56754 ? 45  THR A N   1 
ATOM   335  C CA  . THR A 1 45  ? -27.47208 14.73469 -34.43291 1.000 26.70816 ? 45  THR A CA  1 
ATOM   336  C C   . THR A 1 45  ? -27.30105 14.85183 -32.92140 1.000 22.05705 ? 45  THR A C   1 
ATOM   337  O O   . THR A 1 45  ? -26.62764 14.03499 -32.28628 1.000 26.10838 ? 45  THR A O   1 
ATOM   338  C CB  . THR A 1 45  ? -28.92428 14.41390 -34.78529 1.000 24.08473 ? 45  THR A CB  1 
ATOM   339  O OG1 . THR A 1 45  ? -29.35624 13.27702 -34.02702 1.000 25.75460 ? 45  THR A OG1 1 
ATOM   340  C CG2 . THR A 1 45  ? -29.04976 14.09989 -36.26876 1.000 22.71012 ? 45  THR A CG2 1 
ATOM   341  N N   . SER A 1 46  ? -27.91528 15.88640 -32.33985 1.000 30.53153 ? 46  SER A N   1 
ATOM   342  C CA  . SER A 1 46  ? -27.84868 16.05258 -30.89145 1.000 30.59644 ? 46  SER A CA  1 
ATOM   343  C C   . SER A 1 46  ? -28.30166 14.78771 -30.17629 1.000 30.12814 ? 46  SER A C   1 
ATOM   344  O O   . SER A 1 46  ? -27.68722 14.36718 -29.18911 1.000 29.22578 ? 46  SER A O   1 
ATOM   345  C CB  . SER A 1 46  ? -28.69729 17.25045 -30.45389 1.000 26.04465 ? 46  SER A CB  1 
ATOM   346  N N   . GLU A 1 47  ? -29.36390 14.15104 -30.67709 1.000 27.60323 ? 47  GLU A N   1 
ATOM   347  C CA  . GLU A 1 47  ? -29.89893 12.96142 -30.02738 1.000 20.59180 ? 47  GLU A CA  1 
ATOM   348  C C   . GLU A 1 47  ? -29.01469 11.73431 -30.22122 1.000 24.20457 ? 47  GLU A C   1 
ATOM   349  O O   . GLU A 1 47  ? -29.07202 10.80870 -29.40594 1.000 27.82169 ? 47  GLU A O   1 
ATOM   350  C CB  . GLU A 1 47  ? -31.31251 12.67551 -30.54295 1.000 37.73239 ? 47  GLU A CB  1 
ATOM   351  N N   . ASP A 1 48  ? -28.19340 11.70068 -31.26975 1.000 21.96534 ? 48  ASP A N   1 
ATOM   352  C CA  . ASP A 1 48  ? -27.33370 10.54301 -31.48724 1.000 21.93437 ? 48  ASP A CA  1 
ATOM   353  C C   . ASP A 1 48  ? -26.16096 10.48637 -30.51911 1.000 24.96791 ? 48  ASP A C   1 
ATOM   354  O O   . ASP A 1 48  ? -25.60517 9.40524  -30.29993 1.000 22.54541 ? 48  ASP A O   1 
ATOM   355  C CB  . ASP A 1 48  ? -26.77836 10.54233 -32.91401 1.000 22.34440 ? 48  ASP A CB  1 
ATOM   356  C CG  . ASP A 1 48  ? -27.84766 10.29691 -33.96575 1.000 24.75616 ? 48  ASP A CG  1 
ATOM   357  O OD1 . ASP A 1 48  ? -28.72274 9.43274  -33.74342 1.000 29.42690 ? 48  ASP A OD1 1 
ATOM   358  O OD2 . ASP A 1 48  ? -27.80161 10.96675 -35.01814 1.000 27.46200 ? 48  ASP A OD2 1 
ATOM   359  N N   . MET A 1 49  ? -25.76130 11.61473 -29.94391 1.000 21.82778 ? 49  MET A N   1 
ATOM   360  C CA  . MET A 1 49  ? -24.46510 11.66428 -29.28316 1.000 19.72199 ? 49  MET A CA  1 
ATOM   361  C C   . MET A 1 49  ? -24.43467 10.95550 -27.93392 1.000 19.90150 ? 49  MET A C   1 
ATOM   362  O O   . MET A 1 49  ? -23.34134 10.70310 -27.41430 1.000 23.22334 ? 49  MET A O   1 
ATOM   363  C CB  . MET A 1 49  ? -24.02108 13.12282 -29.14237 1.000 21.27280 ? 49  MET A CB  1 
ATOM   364  C CG  . MET A 1 49  ? -23.43691 13.66652 -30.45086 1.000 27.60736 ? 49  MET A CG  1 
ATOM   365  S SD  . MET A 1 49  ? -23.23131 15.44139 -30.45872 1.000 39.69981 ? 49  MET A SD  1 
ATOM   366  C CE  . MET A 1 49  ? -22.99642 15.75518 -32.20768 1.000 26.53235 ? 49  MET A CE  1 
ATOM   367  N N   . PHE A 1 50  ? -25.58688 10.59442 -27.36776 1.000 20.02370 ? 50  PHE A N   1 
ATOM   368  C CA  . PHE A 1 50  ? -25.58111 9.88112  -26.09295 1.000 17.56312 ? 50  PHE A CA  1 
ATOM   369  C C   . PHE A 1 50  ? -25.20055 8.41194  -26.25435 1.000 20.56628 ? 50  PHE A C   1 
ATOM   370  O O   . PHE A 1 50  ? -24.53461 7.84108  -25.38214 1.000 22.56442 ? 50  PHE A O   1 
ATOM   371  C CB  . PHE A 1 50  ? -26.94963 9.99359  -25.42585 1.000 22.17575 ? 50  PHE A CB  1 
ATOM   372  C CG  . PHE A 1 50  ? -27.36532 11.40130 -25.13907 1.000 24.62908 ? 50  PHE A CG  1 
ATOM   373  C CD1 . PHE A 1 50  ? -26.88937 12.05812 -24.01278 1.000 18.56633 ? 50  PHE A CD1 1 
ATOM   374  C CD2 . PHE A 1 50  ? -28.23702 12.06704 -25.98540 1.000 21.59006 ? 50  PHE A CD2 1 
ATOM   375  C CE1 . PHE A 1 50  ? -27.27896 13.35604 -23.73720 1.000 17.61575 ? 50  PHE A CE1 1 
ATOM   376  C CE2 . PHE A 1 50  ? -28.62351 13.35906 -25.72289 1.000 24.81177 ? 50  PHE A CE2 1 
ATOM   377  C CZ  . PHE A 1 50  ? -28.14004 14.00817 -24.59991 1.000 19.82875 ? 50  PHE A CZ  1 
ATOM   378  N N   . ASN A 1 51  ? -25.62143 7.78106  -27.35130 1.000 18.83460 ? 51  ASN A N   1 
ATOM   379  C CA  . ASN A 1 51  ? -25.34399 6.37352  -27.58403 1.000 23.39867 ? 51  ASN A CA  1 
ATOM   380  C C   . ASN A 1 51  ? -25.16528 6.14931  -29.08017 1.000 23.16090 ? 51  ASN A C   1 
ATOM   381  O O   . ASN A 1 51  ? -25.95764 5.43432  -29.70979 1.000 28.55615 ? 51  ASN A O   1 
ATOM   382  C CB  . ASN A 1 51  ? -26.47204 5.49846  -27.02890 1.000 20.66039 ? 51  ASN A CB  1 
ATOM   383  C CG  . ASN A 1 51  ? -26.11832 4.02278  -27.04279 1.000 39.60055 ? 51  ASN A CG  1 
ATOM   384  O OD1 . ASN A 1 51  ? -24.94237 3.65233  -27.06378 1.000 31.83157 ? 51  ASN A OD1 1 
ATOM   385  N ND2 . ASN A 1 51  ? -27.13681 3.17119  -27.03867 1.000 43.16926 ? 51  ASN A ND2 1 
ATOM   386  N N   . PRO A 1 52  ? -24.14193 6.75117  -29.67892 1.000 22.24256 ? 52  PRO A N   1 
ATOM   387  C CA  . PRO A 1 52  ? -24.00618 6.71928  -31.13693 1.000 19.72387 ? 52  PRO A CA  1 
ATOM   388  C C   . PRO A 1 52  ? -23.47892 5.38344  -31.63627 1.000 17.22805 ? 52  PRO A C   1 
ATOM   389  O O   . PRO A 1 52  ? -22.60551 4.76282  -31.02513 1.000 22.29568 ? 52  PRO A O   1 
ATOM   390  C CB  . PRO A 1 52  ? -22.99326 7.84032  -31.40538 1.000 17.65200 ? 52  PRO A CB  1 
ATOM   391  C CG  . PRO A 1 52  ? -22.12765 7.81457  -30.18870 1.000 20.58014 ? 52  PRO A CG  1 
ATOM   392  C CD  . PRO A 1 52  ? -23.06481 7.51801  -29.03439 1.000 19.31755 ? 52  PRO A CD  1 
ATOM   393  N N   . ASN A 1 53  ? -24.02047 4.94072  -32.76602 1.000 15.35677 ? 53  ASN A N   1 
ATOM   394  C CA  . ASN A 1 53  ? -23.42814 3.85837  -33.54434 1.000 14.81865 ? 53  ASN A CA  1 
ATOM   395  C C   . ASN A 1 53  ? -22.80784 4.52628  -34.77023 1.000 17.07938 ? 53  ASN A C   1 
ATOM   396  O O   . ASN A 1 53  ? -23.48426 4.78612  -35.76714 1.000 16.18096 ? 53  ASN A O   1 
ATOM   397  C CB  . ASN A 1 53  ? -24.46841 2.80108  -33.91607 1.000 19.29704 ? 53  ASN A CB  1 
ATOM   398  C CG  . ASN A 1 53  ? -23.86166 1.61870  -34.63762 1.000 23.10339 ? 53  ASN A CG  1 
ATOM   399  O OD1 . ASN A 1 53  ? -22.83388 1.74636  -35.30666 1.000 19.32272 ? 53  ASN A OD1 1 
ATOM   400  N ND2 . ASN A 1 53  ? -24.49948 0.45133  -34.51047 1.000 21.65075 ? 53  ASN A ND2 1 
ATOM   401  N N   . TYR A 1 54  ? -21.51446 4.83865  -34.67172 1.000 17.21665 ? 54  TYR A N   1 
ATOM   402  C CA  . TYR A 1 54  ? -20.88138 5.63004  -35.71992 1.000 19.25937 ? 54  TYR A CA  1 
ATOM   403  C C   . TYR A 1 54  ? -20.84090 4.87544  -37.03802 1.000 18.13282 ? 54  TYR A C   1 
ATOM   404  O O   . TYR A 1 54  ? -21.05832 5.46666  -38.10105 1.000 20.28508 ? 54  TYR A O   1 
ATOM   405  C CB  . TYR A 1 54  ? -19.47510 6.03856  -35.29147 1.000 14.92448 ? 54  TYR A CB  1 
ATOM   406  C CG  . TYR A 1 54  ? -19.47273 7.10903  -34.23157 1.000 15.35230 ? 54  TYR A CG  1 
ATOM   407  C CD1 . TYR A 1 54  ? -19.75591 8.43316  -34.55473 1.000 16.67917 ? 54  TYR A CD1 1 
ATOM   408  C CD2 . TYR A 1 54  ? -19.18487 6.80061  -32.90782 1.000 19.35029 ? 54  TYR A CD2 1 
ATOM   409  C CE1 . TYR A 1 54  ? -19.75234 9.42261  -33.57960 1.000 20.57347 ? 54  TYR A CE1 1 
ATOM   410  C CE2 . TYR A 1 54  ? -19.17798 7.78086  -31.92790 1.000 17.77900 ? 54  TYR A CE2 1 
ATOM   411  C CZ  . TYR A 1 54  ? -19.45999 9.08818  -32.27107 1.000 18.67578 ? 54  TYR A CZ  1 
ATOM   412  O OH  . TYR A 1 54  ? -19.45092 10.06277 -31.29585 1.000 17.23826 ? 54  TYR A OH  1 
ATOM   413  N N   . GLU A 1 55  ? -20.55053 3.57352  -36.98785 1.000 20.15196 ? 55  GLU A N   1 
ATOM   414  C CA  . GLU A 1 55  ? -20.55165 2.77220  -38.20424 1.000 20.31532 ? 55  GLU A CA  1 
ATOM   415  C C   . GLU A 1 55  ? -21.90632 2.83385  -38.89375 1.000 25.68353 ? 55  GLU A C   1 
ATOM   416  O O   . GLU A 1 55  ? -21.98316 2.99687  -40.11759 1.000 20.49883 ? 55  GLU A O   1 
ATOM   417  C CB  . GLU A 1 55  ? -20.17921 1.32563  -37.88591 1.000 18.39902 ? 55  GLU A CB  1 
ATOM   418  C CG  . GLU A 1 55  ? -18.73519 1.10547  -37.45180 1.000 17.07069 ? 55  GLU A CG  1 
ATOM   419  C CD  . GLU A 1 55  ? -18.48858 1.38580  -35.97734 1.000 19.71048 ? 55  GLU A CD  1 
ATOM   420  O OE1 . GLU A 1 55  ? -19.38629 1.93479  -35.30371 1.000 20.51100 ? 55  GLU A OE1 1 
ATOM   421  O OE2 . GLU A 1 55  ? -17.38589 1.05249  -35.49636 1.000 25.18685 ? 55  GLU A OE2 1 
ATOM   422  N N   . ASP A 1 56  ? -22.99026 2.71251  -38.12393 1.000 18.70880 ? 56  ASP A N   1 
ATOM   423  C CA  . ASP A 1 56  ? -24.31960 2.77611  -38.71795 1.000 19.56351 ? 56  ASP A CA  1 
ATOM   424  C C   . ASP A 1 56  ? -24.61091 4.16666  -39.27149 1.000 22.78071 ? 56  ASP A C   1 
ATOM   425  O O   . ASP A 1 56  ? -25.08899 4.30571  -40.40219 1.000 25.15371 ? 56  ASP A O   1 
ATOM   426  C CB  . ASP A 1 56  ? -25.37461 2.36802  -37.68919 1.000 17.57594 ? 56  ASP A CB  1 
ATOM   427  C CG  . ASP A 1 56  ? -26.77070 2.44723  -38.24040 1.000 26.82540 ? 56  ASP A CG  1 
ATOM   428  O OD1 . ASP A 1 56  ? -27.02907 1.77457  -39.25644 1.000 22.79129 ? 56  ASP A OD1 1 
ATOM   429  O OD2 . ASP A 1 56  ? -27.60056 3.17843  -37.66307 1.000 33.08828 ? 56  ASP A OD2 1 
ATOM   430  N N   . LEU A 1 57  ? -24.32534 5.21200  -38.48768 1.000 20.77344 ? 57  LEU A N   1 
ATOM   431  C CA  . LEU A 1 57  ? -24.55789 6.57528  -38.95392 1.000 17.95409 ? 57  LEU A CA  1 
ATOM   432  C C   . LEU A 1 57  ? -23.77148 6.86733  -40.22661 1.000 19.57606 ? 57  LEU A C   1 
ATOM   433  O O   . LEU A 1 57  ? -24.26812 7.55014  -41.13144 1.000 26.27033 ? 57  LEU A O   1 
ATOM   434  C CB  . LEU A 1 57  ? -24.19173 7.57360  -37.85495 1.000 19.72465 ? 57  LEU A CB  1 
ATOM   435  C CG  . LEU A 1 57  ? -25.05638 7.58355  -36.59558 1.000 23.35091 ? 57  LEU A CG  1 
ATOM   436  C CD1 . LEU A 1 57  ? -24.47279 8.54863  -35.56630 1.000 20.78031 ? 57  LEU A CD1 1 
ATOM   437  C CD2 . LEU A 1 57  ? -26.48816 7.97515  -36.94207 1.000 26.21684 ? 57  LEU A CD2 1 
ATOM   438  N N   . LEU A 1 58  ? -22.54495 6.34827  -40.31818 1.000 18.56097 ? 58  LEU A N   1 
ATOM   439  C CA  . LEU A 1 58  ? -21.70367 6.61873  -41.48111 1.000 20.43865 ? 58  LEU A CA  1 
ATOM   440  C C   . LEU A 1 58  ? -22.19746 5.86476  -42.71343 1.000 20.94203 ? 58  LEU A C   1 
ATOM   441  O O   . LEU A 1 58  ? -22.11277 6.37590  -43.83713 1.000 23.59370 ? 58  LEU A O   1 
ATOM   442  C CB  . LEU A 1 58  ? -20.25215 6.25394  -41.16824 1.000 18.57809 ? 58  LEU A CB  1 
ATOM   443  C CG  . LEU A 1 58  ? -19.23770 6.69184  -42.22691 1.000 20.69236 ? 58  LEU A CG  1 
ATOM   444  C CD1 . LEU A 1 58  ? -19.33072 8.19216  -42.46883 1.000 18.43876 ? 58  LEU A CD1 1 
ATOM   445  C CD2 . LEU A 1 58  ? -17.82938 6.29924  -41.81099 1.000 20.18329 ? 58  LEU A CD2 1 
ATOM   446  N N   . ILE A 1 59  ? -22.71174 4.64511  -42.52773 1.000 25.16051 ? 59  ILE A N   1 
ATOM   447  C CA  . ILE A 1 59  ? -23.20712 3.87120  -43.66608 1.000 30.83210 ? 59  ILE A CA  1 
ATOM   448  C C   . ILE A 1 59  ? -24.30078 4.62970  -44.40277 1.000 25.91439 ? 59  ILE A C   1 
ATOM   449  O O   . ILE A 1 59  ? -24.45778 4.48247  -45.62324 1.000 28.30163 ? 59  ILE A O   1 
ATOM   450  C CB  . ILE A 1 59  ? -23.70207 2.48687  -43.20436 1.000 24.71150 ? 59  ILE A CB  1 
ATOM   451  N N   . ARG A 1 60  ? -25.06144 5.45863  -43.68877 1.000 22.43721 ? 60  ARG A N   1 
ATOM   452  C CA  . ARG A 1 60  ? -26.16055 6.21211  -44.27764 1.000 23.48057 ? 60  ARG A CA  1 
ATOM   453  C C   . ARG A 1 60  ? -25.72090 7.51928  -44.92890 1.000 26.17985 ? 60  ARG A C   1 
ATOM   454  O O   . ARG A 1 60  ? -26.57159 8.24401  -45.45703 1.000 30.36589 ? 60  ARG A O   1 
ATOM   455  C CB  . ARG A 1 60  ? -27.22379 6.50463  -43.21349 1.000 36.86101 ? 60  ARG A CB  1 
ATOM   456  N N   . LYS A 1 61  ? -24.43346 7.84801  -44.90390 1.000 23.17145 ? 61  LYS A N   1 
ATOM   457  C CA  . LYS A 1 61  ? -23.93051 9.08787  -45.47929 1.000 23.35410 ? 61  LYS A CA  1 
ATOM   458  C C   . LYS A 1 61  ? -23.21069 8.80942  -46.79319 1.000 20.08779 ? 61  LYS A C   1 
ATOM   459  O O   . LYS A 1 61  ? -22.52896 7.79018  -46.93245 1.000 29.47936 ? 61  LYS A O   1 
ATOM   460  C CB  . LYS A 1 61  ? -22.97422 9.79066  -44.50642 1.000 20.95437 ? 61  LYS A CB  1 
ATOM   461  C CG  . LYS A 1 61  ? -23.60315 10.14585 -43.16353 1.000 24.65778 ? 61  LYS A CG  1 
ATOM   462  C CD  . LYS A 1 61  ? -24.70821 11.17153 -43.32820 1.000 33.48857 ? 61  LYS A CD  1 
ATOM   463  C CE  . LYS A 1 61  ? -25.26397 11.60387 -41.97557 1.000 35.64251 ? 61  LYS A CE  1 
ATOM   464  N NZ  . LYS A 1 61  ? -26.31728 12.65041 -42.11370 1.000 37.73113 ? 61  LYS A NZ  1 
ATOM   465  N N   . SER A 1 62  ? -23.38264 9.71210  -47.75523 1.000 22.09386 ? 62  SER A N   1 
ATOM   466  C CA  . SER A 1 62  ? -22.63342 9.72378  -49.00585 1.000 23.33040 ? 62  SER A CA  1 
ATOM   467  C C   . SER A 1 62  ? -21.67520 10.90588 -49.00611 1.000 18.96585 ? 62  SER A C   1 
ATOM   468  O O   . SER A 1 62  ? -21.79110 11.81835 -48.18593 1.000 19.56411 ? 62  SER A O   1 
ATOM   469  C CB  . SER A 1 62  ? -23.57501 9.81445  -50.21414 1.000 23.77015 ? 62  SER A CB  1 
ATOM   470  O OG  . SER A 1 62  ? -24.49275 8.73393  -50.23739 1.000 40.90186 ? 62  SER A OG  1 
ATOM   471  N N   . ASN A 1 63  ? -20.72773 10.88705 -49.95074 1.000 19.75588 ? 63  ASN A N   1 
ATOM   472  C CA  . ASN A 1 63  ? -19.75744 11.97668 -50.05358 1.000 17.24789 ? 63  ASN A CA  1 
ATOM   473  C C   . ASN A 1 63  ? -20.43982 13.33889 -50.00953 1.000 21.99345 ? 63  ASN A C   1 
ATOM   474  O O   . ASN A 1 63  ? -20.00776 14.24333 -49.28568 1.000 20.15902 ? 63  ASN A O   1 
ATOM   475  C CB  . ASN A 1 63  ? -18.93627 11.84496 -51.34021 1.000 17.74103 ? 63  ASN A CB  1 
ATOM   476  C CG  . ASN A 1 63  ? -17.97575 10.67932 -51.30999 1.000 21.70339 ? 63  ASN A CG  1 
ATOM   477  O OD1 . ASN A 1 63  ? -17.47862 10.29627 -50.25769 1.000 21.92181 ? 63  ASN A OD1 1 
ATOM   478  N ND2 . ASN A 1 63  ? -17.70029 10.10986 -52.47878 1.000 22.54737 ? 63  ASN A ND2 1 
ATOM   479  N N   . HIS A 1 64  ? -21.51639 13.50522 -50.77961 1.000 19.19117 ? 64  HIS A N   1 
ATOM   480  C CA  . HIS A 1 64  ? -22.13535 14.81486 -50.93355 1.000 19.10637 ? 64  HIS A CA  1 
ATOM   481  C C   . HIS A 1 64  ? -22.83130 15.30111 -49.66758 1.000 19.11608 ? 64  HIS A C   1 
ATOM   482  O O   . HIS A 1 64  ? -23.16923 16.48586 -49.58821 1.000 21.95328 ? 64  HIS A O   1 
ATOM   483  C CB  . HIS A 1 64  ? -23.13216 14.77879 -52.09613 1.000 18.65832 ? 64  HIS A CB  1 
ATOM   484  C CG  . HIS A 1 64  ? -23.57142 16.13142 -52.55893 1.000 18.97814 ? 64  HIS A CG  1 
ATOM   485  N ND1 . HIS A 1 64  ? -22.78936 16.92901 -53.36533 1.000 21.78165 ? 64  HIS A ND1 1 
ATOM   486  C CD2 . HIS A 1 64  ? -24.70890 16.82967 -52.32775 1.000 19.42848 ? 64  HIS A CD2 1 
ATOM   487  C CE1 . HIS A 1 64  ? -23.42714 18.05872 -53.61602 1.000 21.42476 ? 64  HIS A CE1 1 
ATOM   488  N NE2 . HIS A 1 64  ? -24.59495 18.02350 -52.99830 1.000 23.61599 ? 64  HIS A NE2 1 
ATOM   489  N N   . ASN A 1 65  ? -23.04864 14.42868 -48.67859 1.000 18.90494 ? 65  ASN A N   1 
ATOM   490  C CA  . ASN A 1 65  ? -23.61315 14.85590 -47.40291 1.000 21.38673 ? 65  ASN A CA  1 
ATOM   491  C C   . ASN A 1 65  ? -22.62877 15.65627 -46.55493 1.000 20.82820 ? 65  ASN A C   1 
ATOM   492  O O   . ASN A 1 65  ? -23.03759 16.23757 -45.54454 1.000 21.30865 ? 65  ASN A O   1 
ATOM   493  C CB  . ASN A 1 65  ? -24.09122 13.64317 -46.59808 1.000 17.35208 ? 65  ASN A CB  1 
ATOM   494  C CG  . ASN A 1 65  ? -25.13806 12.81346 -47.33237 1.000 21.46040 ? 65  ASN A CG  1 
ATOM   495  O OD1 . ASN A 1 65  ? -25.16828 11.58665 -47.20848 1.000 23.94041 ? 65  ASN A OD1 1 
ATOM   496  N ND2 . ASN A 1 65  ? -25.99974 13.47470 -48.08922 1.000 28.73869 ? 65  ASN A ND2 1 
ATOM   497  N N   . PHE A 1 66  ? -21.35156 15.68946 -46.92020 1.000 17.23057 ? 66  PHE A N   1 
ATOM   498  C CA  . PHE A 1 66  ? -20.34764 16.42979 -46.16662 1.000 15.35182 ? 66  PHE A CA  1 
ATOM   499  C C   . PHE A 1 66  ? -20.04714 17.73742 -46.88005 1.000 18.57135 ? 66  PHE A C   1 
ATOM   500  O O   . PHE A 1 66  ? -19.52886 17.73167 -48.00081 1.000 20.01890 ? 66  PHE A O   1 
ATOM   501  C CB  . PHE A 1 66  ? -19.06629 15.61266 -46.00508 1.000 14.86194 ? 66  PHE A CB  1 
ATOM   502  C CG  . PHE A 1 66  ? -19.25911 14.34967 -45.23659 1.000 18.78511 ? 66  PHE A CG  1 
ATOM   503  C CD1 . PHE A 1 66  ? -19.23745 14.35894 -43.85202 1.000 24.82202 ? 66  PHE A CD1 1 
ATOM   504  C CD2 . PHE A 1 66  ? -19.47527 13.15356 -45.89306 1.000 18.29231 ? 66  PHE A CD2 1 
ATOM   505  C CE1 . PHE A 1 66  ? -19.42369 13.19392 -43.13587 1.000 20.47802 ? 66  PHE A CE1 1 
ATOM   506  C CE2 . PHE A 1 66  ? -19.66276 11.98425 -45.18621 1.000 21.95970 ? 66  PHE A CE2 1 
ATOM   507  C CZ  . PHE A 1 66  ? -19.63396 12.00121 -43.80495 1.000 23.63459 ? 66  PHE A CZ  1 
ATOM   508  N N   . LEU A 1 67  ? -20.37006 18.84909 -46.23186 1.000 15.42552 ? 67  LEU A N   1 
ATOM   509  C CA  . LEU A 1 67  ? -20.11293 20.17691 -46.77271 1.000 16.20757 ? 67  LEU A CA  1 
ATOM   510  C C   . LEU A 1 67  ? -18.82504 20.69156 -46.14526 1.000 17.32784 ? 67  LEU A C   1 
ATOM   511  O O   . LEU A 1 67  ? -18.79291 21.01321 -44.95201 1.000 19.60833 ? 67  LEU A O   1 
ATOM   512  C CB  . LEU A 1 67  ? -21.28549 21.11310 -46.49031 1.000 21.79216 ? 67  LEU A CB  1 
ATOM   513  C CG  . LEU A 1 67  ? -21.09277 22.58168 -46.86316 1.000 27.40405 ? 67  LEU A CG  1 
ATOM   514  C CD1 . LEU A 1 67  ? -20.78693 22.73802 -48.34203 1.000 30.91481 ? 67  LEU A CD1 1 
ATOM   515  C CD2 . LEU A 1 67  ? -22.33197 23.37677 -46.47259 1.000 27.42076 ? 67  LEU A CD2 1 
ATOM   516  N N   . VAL A 1 68  ? -17.76492 20.75518 -46.94479 1.000 17.60435 ? 68  VAL A N   1 
ATOM   517  C CA  . VAL A 1 68  ? -16.45884 21.21951 -46.49711 1.000 20.34384 ? 68  VAL A CA  1 
ATOM   518  C C   . VAL A 1 68  ? -16.21943 22.59755 -47.09386 1.000 24.71041 ? 68  VAL A C   1 
ATOM   519  O O   . VAL A 1 68  ? -16.31039 22.78045 -48.31453 1.000 20.16001 ? 68  VAL A O   1 
ATOM   520  C CB  . VAL A 1 68  ? -15.34762 20.23652 -46.90135 1.000 16.79180 ? 68  VAL A CB  1 
ATOM   521  C CG1 . VAL A 1 68  ? -14.00048 20.72335 -46.39933 1.000 14.16426 ? 68  VAL A CG1 1 
ATOM   522  C CG2 . VAL A 1 68  ? -15.65236 18.85248 -46.35830 1.000 19.37267 ? 68  VAL A CG2 1 
ATOM   523  N N   . GLN A 1 69  ? -15.91978 23.57046 -46.24006 1.000 15.05031 ? 69  GLN A N   1 
ATOM   524  C CA  . GLN A 1 69  ? -15.69823 24.93690 -46.69590 1.000 18.18329 ? 69  GLN A CA  1 
ATOM   525  C C   . GLN A 1 69  ? -14.33386 25.40780 -46.21821 1.000 17.16881 ? 69  GLN A C   1 
ATOM   526  O O   . GLN A 1 69  ? -14.04281 25.36677 -45.01705 1.000 16.21514 ? 69  GLN A O   1 
ATOM   527  C CB  . GLN A 1 69  ? -16.80829 25.86021 -46.19653 1.000 20.06951 ? 69  GLN A CB  1 
ATOM   528  C CG  . GLN A 1 69  ? -18.19470 25.40844 -46.65209 1.000 22.15122 ? 69  GLN A CG  1 
ATOM   529  C CD  . GLN A 1 69  ? -19.31695 26.20331 -46.01607 1.000 47.79062 ? 69  GLN A CD  1 
ATOM   530  O OE1 . GLN A 1 69  ? -19.57251 27.34723 -46.39288 1.000 50.13100 ? 69  GLN A OE1 1 
ATOM   531  N NE2 . GLN A 1 69  ? -19.99656 25.59743 -45.04451 1.000 32.76018 ? 69  GLN A NE2 1 
ATOM   532  N N   . ALA A 1 70  ? -13.49759 25.83537 -47.15947 1.000 18.58744 ? 70  ALA A N   1 
ATOM   533  C CA  . ALA A 1 70  ? -12.20816 26.45187 -46.86963 1.000 20.97438 ? 70  ALA A CA  1 
ATOM   534  C C   . ALA A 1 70  ? -12.35397 27.92949 -47.20966 1.000 23.35904 ? 70  ALA A C   1 
ATOM   535  O O   . ALA A 1 70  ? -12.36598 28.30725 -48.38483 1.000 24.21200 ? 70  ALA A O   1 
ATOM   536  C CB  . ALA A 1 70  ? -11.08517 25.79200 -47.66339 1.000 19.28219 ? 70  ALA A CB  1 
ATOM   537  N N   . GLY A 1 71  ? -12.46760 28.76100 -46.18163 1.000 25.12543 ? 71  GLY A N   1 
ATOM   538  C CA  . GLY A 1 71  ? -12.80216 30.15270 -46.42504 1.000 38.39135 ? 71  GLY A CA  1 
ATOM   539  C C   . GLY A 1 71  ? -14.18551 30.24385 -47.03540 1.000 34.46161 ? 71  GLY A C   1 
ATOM   540  O O   . GLY A 1 71  ? -15.14999 29.65189 -46.53786 1.000 33.92958 ? 71  GLY A O   1 
ATOM   541  N N   . ASN A 1 72  ? -14.29455 30.98533 -48.13476 1.000 41.26367 ? 72  ASN A N   1 
ATOM   542  C CA  . ASN A 1 72  ? -15.54922 31.11626 -48.87419 1.000 53.25327 ? 72  ASN A CA  1 
ATOM   543  C C   . ASN A 1 72  ? -15.59127 30.19519 -50.08802 1.000 55.89704 ? 72  ASN A C   1 
ATOM   544  O O   . ASN A 1 72  ? -16.15365 30.55182 -51.12770 1.000 57.35523 ? 72  ASN A O   1 
ATOM   545  C CB  . ASN A 1 72  ? -15.76657 32.56693 -49.29561 1.000 47.03295 ? 72  ASN A CB  1 
ATOM   546  N N   . VAL A 1 73  ? -15.01102 29.00028 -49.98197 1.000 38.38636 ? 73  VAL A N   1 
ATOM   547  C CA  . VAL A 1 73  ? -14.90806 28.06591 -51.09708 1.000 31.56825 ? 73  VAL A CA  1 
ATOM   548  C C   . VAL A 1 73  ? -15.31013 26.67947 -50.61786 1.000 28.35509 ? 73  VAL A C   1 
ATOM   549  O O   . VAL A 1 73  ? -14.75887 26.17354 -49.63538 1.000 20.87926 ? 73  VAL A O   1 
ATOM   550  C CB  . VAL A 1 73  ? -13.48478 28.03217 -51.68305 1.000 28.57415 ? 73  VAL A CB  1 
ATOM   551  C CG1 . VAL A 1 73  ? -13.40901 27.03177 -52.82815 1.000 34.22024 ? 73  VAL A CG1 1 
ATOM   552  C CG2 . VAL A 1 73  ? -13.06938 29.42221 -52.13629 1.000 40.67214 ? 73  VAL A CG2 1 
ATOM   553  N N   . GLN A 1 74  ? -16.25422 26.05958 -51.31798 1.000 26.65809 ? 74  GLN A N   1 
ATOM   554  C CA  . GLN A 1 74  ? -16.65718 24.70172 -50.98774 1.000 22.31223 ? 74  GLN A CA  1 
ATOM   555  C C   . GLN A 1 74  ? -15.70209 23.71489 -51.64393 1.000 21.54612 ? 74  GLN A C   1 
ATOM   556  O O   . GLN A 1 74  ? -15.37941 23.84440 -52.82813 1.000 24.94956 ? 74  GLN A O   1 
ATOM   557  C CB  . GLN A 1 74  ? -18.09421 24.43310 -51.44022 1.000 26.37581 ? 74  GLN A CB  1 
ATOM   558  C CG  . GLN A 1 74  ? -18.58232 23.03831 -51.09052 1.000 32.74394 ? 74  GLN A CG  1 
ATOM   559  C CD  . GLN A 1 74  ? -19.96575 22.74339 -51.62935 1.000 37.51077 ? 74  GLN A CD  1 
ATOM   560  O OE1 . GLN A 1 74  ? -20.59939 23.59897 -52.24502 1.000 38.40921 ? 74  GLN A OE1 1 
ATOM   561  N NE2 . GLN A 1 74  ? -20.44045 21.52373 -51.40335 1.000 35.24077 ? 74  GLN A NE2 1 
ATOM   562  N N   . LEU A 1 75  ? -15.24482 22.73602 -50.87058 1.000 19.85658 ? 75  LEU A N   1 
ATOM   563  C CA  . LEU A 1 75  ? -14.38459 21.67340 -51.37464 1.000 22.60902 ? 75  LEU A CA  1 
ATOM   564  C C   . LEU A 1 75  ? -15.22479 20.43810 -51.65649 1.000 25.96322 ? 75  LEU A C   1 
ATOM   565  O O   . LEU A 1 75  ? -15.96642 19.97607 -50.78113 1.000 26.58964 ? 75  LEU A O   1 
ATOM   566  C CB  . LEU A 1 75  ? -13.29286 21.33213 -50.36535 1.000 18.30490 ? 75  LEU A CB  1 
ATOM   567  C CG  . LEU A 1 75  ? -12.39083 22.48512 -49.94781 1.000 18.90539 ? 75  LEU A CG  1 
ATOM   568  C CD1 . LEU A 1 75  ? -11.36764 21.95127 -48.97116 1.000 17.35805 ? 75  LEU A CD1 1 
ATOM   569  C CD2 . LEU A 1 75  ? -11.72371 23.11192 -51.15878 1.000 22.03667 ? 75  LEU A CD2 1 
ATOM   570  N N   . ARG A 1 76  ? -15.09603 19.89158 -52.86196 1.000 16.87274 ? 76  ARG A N   1 
ATOM   571  C CA  . ARG A 1 76  ? -15.90404 18.73686 -53.23914 1.000 22.56142 ? 76  ARG A CA  1 
ATOM   572  C C   . ARG A 1 76  ? -15.34070 17.47368 -52.59685 1.000 13.38881 ? 76  ARG A C   1 
ATOM   573  O O   . ARG A 1 76  ? -14.17294 17.12936 -52.80692 1.000 16.53264 ? 76  ARG A O   1 
ATOM   574  C CB  . ARG A 1 76  ? -15.95879 18.59355 -54.75740 1.000 20.05241 ? 76  ARG A CB  1 
ATOM   575  C CG  . ARG A 1 76  ? -16.83701 17.44751 -55.21657 1.000 27.43035 ? 76  ARG A CG  1 
ATOM   576  C CD  . ARG A 1 76  ? -17.15123 17.57092 -56.68302 1.000 30.19745 ? 76  ARG A CD  1 
ATOM   577  N NE  . ARG A 1 76  ? -18.05512 16.51871 -57.12189 1.000 25.95812 ? 76  ARG A NE  1 
ATOM   578  C CZ  . ARG A 1 76  ? -19.37474 16.56813 -56.99618 1.000 24.66209 ? 76  ARG A CZ  1 
ATOM   579  N NH1 . ARG A 1 76  ? -19.97627 17.59863 -56.42522 1.000 24.49819 ? 76  ARG A NH1 1 
ATOM   580  N NH2 . ARG A 1 76  ? -20.10795 15.56090 -57.46028 1.000 28.92273 ? 76  ARG A NH2 1 
ATOM   581  N N   . VAL A 1 77  ? -16.17009 16.78682 -51.81287 1.000 17.42340 ? 77  VAL A N   1 
ATOM   582  C CA  . VAL A 1 77  ? -15.76596 15.53444 -51.18823 1.000 17.28492 ? 77  VAL A CA  1 
ATOM   583  C C   . VAL A 1 77  ? -15.94638 14.39548 -52.18410 1.000 16.90012 ? 77  VAL A C   1 
ATOM   584  O O   . VAL A 1 77  ? -17.02737 14.21447 -52.75956 1.000 19.77767 ? 77  VAL A O   1 
ATOM   585  C CB  . VAL A 1 77  ? -16.56649 15.28763 -49.90220 1.000 20.47949 ? 77  VAL A CB  1 
ATOM   586  C CG1 . VAL A 1 77  ? -16.26532 13.90594 -49.34503 1.000 18.12939 ? 77  VAL A CG1 1 
ATOM   587  C CG2 . VAL A 1 77  ? -16.24258 16.36155 -48.87833 1.000 16.46890 ? 77  VAL A CG2 1 
ATOM   588  N N   . ILE A 1 78  ? -14.88359 13.61604 -52.38198 1.000 15.27864 ? 78  ILE A N   1 
ATOM   589  C CA  . ILE A 1 78  ? -14.88087 12.50691 -53.32547 1.000 16.24338 ? 78  ILE A CA  1 
ATOM   590  C C   . ILE A 1 78  ? -14.59062 11.16679 -52.66763 1.000 20.63776 ? 78  ILE A C   1 
ATOM   591  O O   . ILE A 1 78  ? -14.49515 10.15402 -53.37089 1.000 20.22657 ? 78  ILE A O   1 
ATOM   592  C CB  . ILE A 1 78  ? -13.88977 12.75749 -54.48292 1.000 16.62378 ? 78  ILE A CB  1 
ATOM   593  C CG1 . ILE A 1 78  ? -12.45752 12.91044 -53.95410 1.000 17.76286 ? 78  ILE A CG1 1 
ATOM   594  C CG2 . ILE A 1 78  ? -14.28974 14.01035 -55.26273 1.000 17.83870 ? 78  ILE A CG2 1 
ATOM   595  C CD1 . ILE A 1 78  ? -11.41584 13.05549 -55.05735 1.000 19.73911 ? 78  ILE A CD1 1 
ATOM   596  N N   . GLY A 1 79  ? -14.46564 11.12508 -51.34572 1.000 16.01498 ? 79  GLY A N   1 
ATOM   597  C CA  . GLY A 1 79  ? -14.33552 9.86841  -50.63818 1.000 19.43457 ? 79  GLY A CA  1 
ATOM   598  C C   . GLY A 1 79  ? -14.42281 10.11445 -49.15129 1.000 19.66672 ? 79  GLY A C   1 
ATOM   599  O O   . GLY A 1 79  ? -14.24198 11.24006 -48.68289 1.000 20.29071 ? 79  GLY A O   1 
ATOM   600  N N   . HIS A 1 80  ? -14.71130 9.04495  -48.41285 1.000 20.38761 ? 80  HIS A N   1 
ATOM   601  C CA  . HIS A 1 80  ? -14.80951 9.17993  -46.96568 1.000 17.25528 ? 80  HIS A CA  1 
ATOM   602  C C   . HIS A 1 80  ? -14.56013 7.83452  -46.30772 1.000 25.06338 ? 80  HIS A C   1 
ATOM   603  O O   . HIS A 1 80  ? -14.96756 6.79456  -46.82690 1.000 24.41564 ? 80  HIS A O   1 
ATOM   604  C CB  . HIS A 1 80  ? -16.17904 9.72200  -46.54326 1.000 17.59389 ? 80  HIS A CB  1 
ATOM   605  C CG  . HIS A 1 80  ? -17.31187 8.77980  -46.80390 1.000 21.62115 ? 80  HIS A CG  1 
ATOM   606  N ND1 . HIS A 1 80  ? -18.00082 8.75434  -47.99883 1.000 22.32746 ? 80  HIS A ND1 1 
ATOM   607  C CD2 . HIS A 1 80  ? -17.89169 7.84460  -46.01378 1.000 25.38742 ? 80  HIS A CD2 1 
ATOM   608  C CE1 . HIS A 1 80  ? -18.95139 7.83709  -47.93511 1.000 26.57461 ? 80  HIS A CE1 1 
ATOM   609  N NE2 . HIS A 1 80  ? -18.90648 7.27095  -46.74146 1.000 23.03864 ? 80  HIS A NE2 1 
ATOM   610  N N   . SER A 1 81  ? -13.88802 7.86792  -45.16160 1.000 18.11147 ? 81  SER A N   1 
ATOM   611  C CA  . SER A 1 81  ? -13.67962 6.67452  -44.36250 1.000 19.50899 ? 81  SER A CA  1 
ATOM   612  C C   . SER A 1 81  ? -13.53565 7.10024  -42.91367 1.000 21.40222 ? 81  SER A C   1 
ATOM   613  O O   . SER A 1 81  ? -13.32691 8.27720  -42.60962 1.000 21.41863 ? 81  SER A O   1 
ATOM   614  C CB  . SER A 1 81  ? -12.44526 5.88906  -44.80988 1.000 21.74055 ? 81  SER A CB  1 
ATOM   615  O OG  . SER A 1 81  ? -11.28504 6.68515  -44.69834 1.000 23.54952 ? 81  SER A OG  1 
ATOM   616  N N   . MET A 1 82  ? -13.65673 6.12431  -42.02333 1.000 19.28910 ? 82  MET A N   1 
ATOM   617  C CA  . MET A 1 82  ? -13.52853 6.34342  -40.59458 1.000 17.58708 ? 82  MET A CA  1 
ATOM   618  C C   . MET A 1 82  ? -12.31586 5.58123  -40.08929 1.000 22.11270 ? 82  MET A C   1 
ATOM   619  O O   . MET A 1 82  ? -12.13419 4.40094  -40.41623 1.000 21.38026 ? 82  MET A O   1 
ATOM   620  C CB  . MET A 1 82  ? -14.79124 5.90028  -39.85507 1.000 19.33649 ? 82  MET A CB  1 
ATOM   621  C CG  . MET A 1 82  ? -14.69241 6.01088  -38.35086 1.000 15.43333 ? 82  MET A CG  1 
ATOM   622  S SD  . MET A 1 82  ? -16.29871 5.89950  -37.57668 1.000 22.20087 ? 82  MET A SD  1 
ATOM   623  C CE  . MET A 1 82  ? -16.78496 4.20836  -37.94018 1.000 23.67984 ? 82  MET A CE  1 
ATOM   624  N N   . GLN A 1 83  ? -11.48511 6.26184  -39.30509 1.000 14.97488 ? 83  GLN A N   1 
ATOM   625  C CA  . GLN A 1 83  ? -10.33499 5.64329  -38.65932 1.000 17.13501 ? 83  GLN A CA  1 
ATOM   626  C C   . GLN A 1 83  ? -10.42156 5.96254  -37.17512 1.000 18.73281 ? 83  GLN A C   1 
ATOM   627  O O   . GLN A 1 83  ? -10.20156 7.10791  -36.77146 1.000 19.11588 ? 83  GLN A O   1 
ATOM   628  C CB  . GLN A 1 83  ? -9.02065  6.15454  -39.24568 1.000 18.47957 ? 83  GLN A CB  1 
ATOM   629  C CG  . GLN A 1 83  ? -7.80382  5.59454  -38.54918 1.000 17.76322 ? 83  GLN A CG  1 
ATOM   630  C CD  . GLN A 1 83  ? -6.51237  6.13594  -39.11754 1.000 19.60458 ? 83  GLN A CD  1 
ATOM   631  O OE1 . GLN A 1 83  ? -6.50278  7.14979  -39.81822 1.000 21.60937 ? 83  GLN A OE1 1 
ATOM   632  N NE2 . GLN A 1 83  ? -5.41066  5.45896  -38.82210 1.000 27.66487 ? 83  GLN A NE2 1 
ATOM   633  N N   . ASN A 1 84  ? -10.76104 4.96729  -36.36216 1.000 18.16277 ? 84  ASN A N   1 
ATOM   634  C CA  . ASN A 1 84  ? -10.94345 5.16431  -34.92248 1.000 13.70563 ? 84  ASN A CA  1 
ATOM   635  C C   . ASN A 1 84  ? -11.97072 6.27681  -34.74679 1.000 15.27503 ? 84  ASN A C   1 
ATOM   636  O O   . ASN A 1 84  ? -13.09070 6.14095  -35.26842 1.000 16.45548 ? 84  ASN A O   1 
ATOM   637  C CB  . ASN A 1 84  ? -9.57395  5.39122  -34.29023 1.000 21.71814 ? 84  ASN A CB  1 
ATOM   638  C CG  . ASN A 1 84  ? -8.65743  4.19987  -34.48454 1.000 18.92363 ? 84  ASN A CG  1 
ATOM   639  O OD1 . ASN A 1 84  ? -9.05520  3.05581  -34.23721 1.000 19.70855 ? 84  ASN A OD1 1 
ATOM   640  N ND2 . ASN A 1 84  ? -7.44490  4.45012  -34.96634 1.000 19.05860 ? 84  ASN A ND2 1 
ATOM   641  N N   . CYS A 1 85  ? -11.66259 7.37855  -34.06048 1.000 13.67730 ? 85  CYS A N   1 
ATOM   642  C CA  . CYS A 1 85  ? -12.66317 8.40684  -33.79889 1.000 13.16253 ? 85  CYS A CA  1 
ATOM   643  C C   . CYS A 1 85  ? -12.53877 9.61358  -34.72780 1.000 13.39554 ? 85  CYS A C   1 
ATOM   644  O O   . CYS A 1 85  ? -13.13912 10.65741 -34.45663 1.000 14.79982 ? 85  CYS A O   1 
ATOM   645  C CB  . CYS A 1 85  ? -12.59155 8.86233  -32.33870 1.000 11.69054 ? 85  CYS A CB  1 
ATOM   646  S SG  . CYS A 1 85  ? -12.80291 7.53447  -31.14669 1.000 17.04051 ? 85  CYS A SG  1 
ATOM   647  N N   . VAL A 1 86  ? -11.80769 9.49184  -35.83594 1.000 16.00502 ? 86  VAL A N   1 
ATOM   648  C CA  . VAL A 1 86  ? -11.73011 10.58161 -36.79978 1.000 14.28729 ? 86  VAL A CA  1 
ATOM   649  C C   . VAL A 1 86  ? -12.33109 10.12848 -38.11917 1.000 19.35513 ? 86  VAL A C   1 
ATOM   650  O O   . VAL A 1 86  ? -12.27474 8.94889  -38.47947 1.000 20.55830 ? 86  VAL A O   1 
ATOM   651  C CB  . VAL A 1 86  ? -10.28458 11.08404 -37.00843 1.000 17.89462 ? 86  VAL A CB  1 
ATOM   652  C CG1 . VAL A 1 86  ? -9.81460  11.83113 -35.77485 1.000 14.62499 ? 86  VAL A CG1 1 
ATOM   653  C CG2 . VAL A 1 86  ? -9.35646  9.92855  -37.32587 1.000 21.08417 ? 86  VAL A CG2 1 
ATOM   654  N N   . LEU A 1 87  ? -12.93422 11.07742 -38.82743 1.000 14.38261 ? 87  LEU A N   1 
ATOM   655  C CA  . LEU A 1 87  ? -13.32236 10.88423 -40.21478 1.000 14.28937 ? 87  LEU A CA  1 
ATOM   656  C C   . LEU A 1 87  ? -12.24572 11.44270 -41.12825 1.000 19.38635 ? 87  LEU A C   1 
ATOM   657  O O   . LEU A 1 87  ? -11.64356 12.47947 -40.83610 1.000 19.63213 ? 87  LEU A O   1 
ATOM   658  C CB  . LEU A 1 87  ? -14.64865 11.57259 -40.52800 1.000 22.23213 ? 87  LEU A CB  1 
ATOM   659  C CG  . LEU A 1 87  ? -15.91640 10.95899 -39.96062 1.000 26.08553 ? 87  LEU A CG  1 
ATOM   660  C CD1 . LEU A 1 87  ? -17.11270 11.75492 -40.45722 1.000 24.75814 ? 87  LEU A CD1 1 
ATOM   661  C CD2 . LEU A 1 87  ? -16.02408 9.50278  -40.36834 1.000 32.00799 ? 87  LEU A CD2 1 
ATOM   662  N N   . LYS A 1 88  ? -12.02296 10.76205 -42.24770 1.000 16.38097 ? 88  LYS A N   1 
ATOM   663  C CA  . LYS A 1 88  ? -11.11030 11.22853 -43.27862 1.000 14.85707 ? 88  LYS A CA  1 
ATOM   664  C C   . LYS A 1 88  ? -11.92764 11.46488 -44.53873 1.000 14.96130 ? 88  LYS A C   1 
ATOM   665  O O   . LYS A 1 88  ? -12.49921 10.52485 -45.09994 1.000 22.31046 ? 88  LYS A O   1 
ATOM   666  C CB  . LYS A 1 88  ? -9.97915  10.22367 -43.49238 1.000 15.91694 ? 88  LYS A CB  1 
ATOM   667  C CG  . LYS A 1 88  ? -8.96095  10.25687 -42.35382 1.000 22.27998 ? 88  LYS A CG  1 
ATOM   668  C CD  . LYS A 1 88  ? -8.44790  8.88036  -41.96702 1.000 31.00587 ? 88  LYS A CD  1 
ATOM   669  C CE  . LYS A 1 88  ? -7.67494  8.21959  -43.08497 1.000 30.68009 ? 88  LYS A CE  1 
ATOM   670  N NZ  . LYS A 1 88  ? -7.13759  6.90049  -42.64541 1.000 25.17970 ? 88  LYS A NZ  1 
ATOM   671  N N   . LEU A 1 89  ? -12.01826 12.72374 -44.95453 1.000 12.94275 ? 89  LEU A N   1 
ATOM   672  C CA  . LEU A 1 89  ? -12.78856 13.11959 -46.12825 1.000 14.13891 ? 89  LEU A CA  1 
ATOM   673  C C   . LEU A 1 89  ? -11.80148 13.44785 -47.23427 1.000 15.89379 ? 89  LEU A C   1 
ATOM   674  O O   . LEU A 1 89  ? -11.07231 14.43742 -47.14319 1.000 15.56807 ? 89  LEU A O   1 
ATOM   675  C CB  . LEU A 1 89  ? -13.68831 14.31753 -45.82824 1.000 15.51489 ? 89  LEU A CB  1 
ATOM   676  C CG  . LEU A 1 89  ? -14.58795 14.13993 -44.60740 1.000 18.00454 ? 89  LEU A CG  1 
ATOM   677  C CD1 . LEU A 1 89  ? -15.30445 15.44211 -44.27771 1.000 18.76331 ? 89  LEU A CD1 1 
ATOM   678  C CD2 . LEU A 1 89  ? -15.58459 13.00382 -44.84320 1.000 15.06268 ? 89  LEU A CD2 1 
ATOM   679  N N   . LYS A 1 90  ? -11.76629 12.61621 -48.27121 1.000 16.70734 ? 90  LYS A N   1 
ATOM   680  C CA  . LYS A 1 90  ? -10.95270 12.92805 -49.43659 1.000 12.19034 ? 90  LYS A CA  1 
ATOM   681  C C   . LYS A 1 90  ? -11.66497 13.99201 -50.25327 1.000 16.10899 ? 90  LYS A C   1 
ATOM   682  O O   . LYS A 1 90  ? -12.87267 13.89014 -50.49392 1.000 20.06929 ? 90  LYS A O   1 
ATOM   683  C CB  . LYS A 1 90  ? -10.71607 11.68204 -50.28474 1.000 18.32904 ? 90  LYS A CB  1 
ATOM   684  C CG  . LYS A 1 90  ? -9.70910  11.89657 -51.39385 1.000 21.18301 ? 90  LYS A CG  1 
ATOM   685  C CD  . LYS A 1 90  ? -9.39548  10.60307 -52.12474 1.000 29.86410 ? 90  LYS A CD  1 
ATOM   686  C CE  . LYS A 1 90  ? -8.26258  10.80924 -53.12332 1.000 31.54179 ? 90  LYS A CE  1 
ATOM   687  N NZ  . LYS A 1 90  ? -7.97105  9.57442  -53.89914 1.000 35.90804 ? 90  LYS A NZ  1 
ATOM   688  N N   . VAL A 1 91  ? -10.92827 15.02188 -50.65413 1.000 13.95288 ? 91  VAL A N   1 
ATOM   689  C CA  . VAL A 1 91  ? -11.47888 16.11129 -51.44327 1.000 14.32422 ? 91  VAL A CA  1 
ATOM   690  C C   . VAL A 1 91  ? -10.71773 16.16422 -52.76341 1.000 14.17223 ? 91  VAL A C   1 
ATOM   691  O O   . VAL A 1 91  ? -9.63134  15.60019 -52.90467 1.000 16.71205 ? 91  VAL A O   1 
ATOM   692  C CB  . VAL A 1 91  ? -11.41348 17.46026 -50.69502 1.000 15.89944 ? 91  VAL A CB  1 
ATOM   693  C CG1 . VAL A 1 91  ? -12.36020 17.43988 -49.50312 1.000 15.71039 ? 91  VAL A CG1 1 
ATOM   694  C CG2 . VAL A 1 91  ? -9.99172  17.75166 -50.23967 1.000 15.33336 ? 91  VAL A CG2 1 
ATOM   695  N N   . ASP A 1 92  ? -11.30857 16.83756 -53.74591 1.000 18.07520 ? 92  ASP A N   1 
ATOM   696  C CA  . ASP A 1 92  ? -10.75074 16.83351 -55.09193 1.000 17.48716 ? 92  ASP A CA  1 
ATOM   697  C C   . ASP A 1 92  ? -9.67875  17.89522 -55.29858 1.000 18.72521 ? 92  ASP A C   1 
ATOM   698  O O   . ASP A 1 92  ? -9.17275  18.03538 -56.41706 1.000 21.39114 ? 92  ASP A O   1 
ATOM   699  C CB  . ASP A 1 92  ? -11.86386 16.98699 -56.13234 1.000 20.63686 ? 92  ASP A CB  1 
ATOM   700  C CG  . ASP A 1 92  ? -12.45773 18.39429 -56.18238 1.000 22.67131 ? 92  ASP A CG  1 
ATOM   701  O OD1 . ASP A 1 92  ? -12.06542 19.27610 -55.38819 1.000 26.90741 ? 92  ASP A OD1 1 
ATOM   702  O OD2 . ASP A 1 92  ? -13.33758 18.61795 -57.05017 1.000 30.34518 ? 92  ASP A OD2 1 
ATOM   703  N N   . THR A 1 93  ? -9.29865  18.62479 -54.25062 1.000 19.93241 ? 93  THR A N   1 
ATOM   704  C CA  A THR A 1 93  ? -8.26649  19.64360 -54.35209 0.500 16.52960 ? 93  THR A CA  1 
ATOM   705  C CA  B THR A 1 93  ? -8.28308  19.66826 -54.33443 0.500 16.53052 ? 93  THR A CA  1 
ATOM   706  C C   . THR A 1 93  ? -7.27896  19.47275 -53.20918 1.000 13.75484 ? 93  THR A C   1 
ATOM   707  O O   . THR A 1 93  ? -7.67290  19.24055 -52.06361 1.000 15.43823 ? 93  THR A O   1 
ATOM   708  C CB  A THR A 1 93  ? -8.86531  21.06132 -54.33150 0.500 21.81871 ? 93  THR A CB  1 
ATOM   709  C CB  B THR A 1 93  ? -8.91228  21.06378 -54.24006 0.500 21.80811 ? 93  THR A CB  1 
ATOM   710  O OG1 A THR A 1 93  ? -9.58166  21.26735 -53.11053 0.500 21.64906 ? 93  THR A OG1 1 
ATOM   711  O OG1 B THR A 1 93  ? -9.87906  21.23043 -55.28403 0.500 20.46865 ? 93  THR A OG1 1 
ATOM   712  C CG2 A THR A 1 93  ? -9.82289  21.25021 -55.49352 0.500 21.16677 ? 93  THR A CG2 1 
ATOM   713  C CG2 B THR A 1 93  ? -7.84991  22.14494 -54.36137 0.500 14.03097 ? 93  THR A CG2 1 
ATOM   714  N N   . ALA A 1 94  ? -5.99191  19.56485 -53.53049 1.000 12.56425 ? 94  ALA A N   1 
ATOM   715  C CA  . ALA A 1 94  ? -4.97155  19.49536 -52.49843 1.000 12.58058 ? 94  ALA A CA  1 
ATOM   716  C C   . ALA A 1 94  ? -4.77032  20.87670 -51.89284 1.000 14.08178 ? 94  ALA A C   1 
ATOM   717  O O   . ALA A 1 94  ? -4.78687  21.88655 -52.60115 1.000 18.05246 ? 94  ALA A O   1 
ATOM   718  C CB  . ALA A 1 94  ? -3.65638  18.97438 -53.07900 1.000 15.35307 ? 94  ALA A CB  1 
ATOM   719  N N   . ASN A 1 95  ? -4.60260  20.92344 -50.57682 1.000 13.59321 ? 95  ASN A N   1 
ATOM   720  C CA  . ASN A 1 95  ? -4.41510  22.20771 -49.91623 1.000 14.10453 ? 95  ASN A CA  1 
ATOM   721  C C   . ASN A 1 95  ? -3.07204  22.80255 -50.31465 1.000 13.29999 ? 95  ASN A C   1 
ATOM   722  O O   . ASN A 1 95  ? -2.03529  22.23652 -49.95716 1.000 16.12979 ? 95  ASN A O   1 
ATOM   723  C CB  . ASN A 1 95  ? -4.48927  22.03183 -48.40098 1.000 15.52505 ? 95  ASN A CB  1 
ATOM   724  C CG  . ASN A 1 95  ? -4.36369  23.34864 -47.65114 1.000 13.23351 ? 95  ASN A CG  1 
ATOM   725  O OD1 . ASN A 1 95  ? -4.29567  24.41846 -48.25398 1.000 13.21985 ? 95  ASN A OD1 1 
ATOM   726  N ND2 . ASN A 1 95  ? -4.34872  23.27177 -46.32186 1.000 17.45216 ? 95  ASN A ND2 1 
ATOM   727  N N   . PRO A 1 96  ? -3.03175  23.92152 -51.04226 1.000 17.48795 ? 96  PRO A N   1 
ATOM   728  C CA  . PRO A 1 96  ? -1.73099  24.47069 -51.44995 1.000 18.27578 ? 96  PRO A CA  1 
ATOM   729  C C   . PRO A 1 96  ? -0.88914  24.95838 -50.28848 1.000 17.26066 ? 96  PRO A C   1 
ATOM   730  O O   . PRO A 1 96  ? 0.33097   25.09769 -50.44767 1.000 19.58538 ? 96  PRO A O   1 
ATOM   731  C CB  . PRO A 1 96  ? -2.11502  25.62872 -52.37783 1.000 21.66938 ? 96  PRO A CB  1 
ATOM   732  C CG  . PRO A 1 96  ? -3.45853  26.04464 -51.90119 1.000 24.00317 ? 96  PRO A CG  1 
ATOM   733  C CD  . PRO A 1 96  ? -4.14972  24.76804 -51.49285 1.000 21.00926 ? 96  PRO A CD  1 
ATOM   734  N N   . LYS A 1 97  ? -1.49539  25.22208 -49.13401 1.000 15.53852 ? 97  LYS A N   1 
ATOM   735  C CA  . LYS A 1 97  ? -0.78338  25.70697 -47.96155 1.000 15.04497 ? 97  LYS A CA  1 
ATOM   736  C C   . LYS A 1 97  ? -0.37298  24.58397 -47.02749 1.000 16.84964 ? 97  LYS A C   1 
ATOM   737  O O   . LYS A 1 97  ? -0.00680  24.85653 -45.88019 1.000 15.25163 ? 97  LYS A O   1 
ATOM   738  C CB  . LYS A 1 97  ? -1.64501  26.71676 -47.19859 1.000 17.14941 ? 97  LYS A CB  1 
ATOM   739  C CG  . LYS A 1 97  ? -2.01717  27.95599 -47.99578 1.000 22.84129 ? 97  LYS A CG  1 
ATOM   740  C CD  . LYS A 1 97  ? -2.95349  28.84326 -47.19815 1.000 21.19656 ? 97  LYS A CD  1 
ATOM   741  C CE  . LYS A 1 97  ? -3.30739  30.11252 -47.94896 1.000 29.07375 ? 97  LYS A CE  1 
ATOM   742  N NZ  . LYS A 1 97  ? -4.26022  30.95068 -47.16681 1.000 32.90770 ? 97  LYS A NZ  1 
ATOM   743  N N   . THR A 1 98  ? -0.43224  23.33967 -47.48135 1.000 12.73212 ? 98  THR A N   1 
ATOM   744  C CA  . THR A 1 98  ? -0.03840  22.21625 -46.64472 1.000 16.36071 ? 98  THR A CA  1 
ATOM   745  C C   . THR A 1 98  ? 1.41388   22.36785 -46.21313 1.000 15.82317 ? 98  THR A C   1 
ATOM   746  O O   . THR A 1 98  ? 2.30238   22.44634 -47.07159 1.000 18.20038 ? 98  THR A O   1 
ATOM   747  C CB  . THR A 1 98  ? -0.21608  20.89484 -47.38763 1.000 18.46439 ? 98  THR A CB  1 
ATOM   748  O OG1 . THR A 1 98  ? -1.58994  20.75270 -47.76834 1.000 14.11205 ? 98  THR A OG1 1 
ATOM   749  C CG2 . THR A 1 98  ? 0.17211   19.72745 -46.49341 1.000 14.97815 ? 98  THR A CG2 1 
ATOM   750  N N   . PRO A 1 99  ? 1.69848   22.40928 -44.92138 1.000 14.61465 ? 99  PRO A N   1 
ATOM   751  C CA  . PRO A 1 99  ? 3.08701   22.43757 -44.46628 1.000 10.96972 ? 99  PRO A CA  1 
ATOM   752  C C   . PRO A 1 99  ? 3.66982   21.03434 -44.47697 1.000 13.56693 ? 99  PRO A C   1 
ATOM   753  O O   . PRO A 1 99  ? 2.95347   20.03766 -44.59081 1.000 16.02570 ? 99  PRO A O   1 
ATOM   754  C CB  . PRO A 1 99  ? 2.95817   22.97383 -43.03876 1.000 15.53063 ? 99  PRO A CB  1 
ATOM   755  C CG  . PRO A 1 99  ? 1.65191   22.39465 -42.57785 1.000 12.45968 ? 99  PRO A CG  1 
ATOM   756  C CD  . PRO A 1 99  ? 0.74437   22.40726 -43.79737 1.000 15.21286 ? 99  PRO A CD  1 
ATOM   757  N N   . LYS A 1 100 ? 4.99531   20.96735 -44.35799 1.000 14.35774 ? 100 LYS A N   1 
ATOM   758  C CA  . LYS A 1 100 ? 5.60614   19.70390 -43.98752 1.000 14.23767 ? 100 LYS A CA  1 
ATOM   759  C C   . LYS A 1 100 ? 5.05546   19.30823 -42.62685 1.000 13.65150 ? 100 LYS A C   1 
ATOM   760  O O   . LYS A 1 100 ? 4.97777   20.14072 -41.71782 1.000 16.54120 ? 100 LYS A O   1 
ATOM   761  C CB  . LYS A 1 100 ? 7.12838   19.82639 -43.93674 1.000 18.05507 ? 100 LYS A CB  1 
ATOM   762  C CG  . LYS A 1 100 ? 7.82162   18.53682 -43.55345 1.000 19.40177 ? 100 LYS A CG  1 
ATOM   763  C CD  . LYS A 1 100 ? 9.33231   18.68257 -43.61600 1.000 22.58518 ? 100 LYS A CD  1 
ATOM   764  C CE  . LYS A 1 100 ? 10.03185  17.39444 -43.21780 1.000 26.21121 ? 100 LYS A CE  1 
ATOM   765  N NZ  . LYS A 1 100 ? 11.50578  17.51431 -43.41227 1.000 26.51824 ? 100 LYS A NZ  1 
ATOM   766  N N   . TYR A 1 101 ? 4.63320   18.05548 -42.49102 1.000 15.01748 ? 101 TYR A N   1 
ATOM   767  C CA  . TYR A 1 101 ? 3.95206   17.67613 -41.26400 1.000 15.21019 ? 101 TYR A CA  1 
ATOM   768  C C   . TYR A 1 101 ? 4.17815   16.20541 -40.96298 1.000 16.73326 ? 101 TYR A C   1 
ATOM   769  O O   . TYR A 1 101 ? 4.60636   15.42659 -41.81761 1.000 19.21892 ? 101 TYR A O   1 
ATOM   770  C CB  . TYR A 1 101 ? 2.44165   17.96043 -41.34416 1.000 13.30054 ? 101 TYR A CB  1 
ATOM   771  C CG  . TYR A 1 101 ? 1.68622   16.96380 -42.19017 1.000 16.29237 ? 101 TYR A CG  1 
ATOM   772  C CD1 . TYR A 1 101 ? 1.57042   17.13661 -43.56389 1.000 14.99146 ? 101 TYR A CD1 1 
ATOM   773  C CD2 . TYR A 1 101 ? 1.10819   15.83719 -41.61501 1.000 15.12401 ? 101 TYR A CD2 1 
ATOM   774  C CE1 . TYR A 1 101 ? 0.87833   16.21530 -44.34405 1.000 18.78104 ? 101 TYR A CE1 1 
ATOM   775  C CE2 . TYR A 1 101 ? 0.42431   14.91724 -42.38000 1.000 19.16310 ? 101 TYR A CE2 1 
ATOM   776  C CZ  . TYR A 1 101 ? 0.31279   15.10872 -43.73752 1.000 20.83860 ? 101 TYR A CZ  1 
ATOM   777  O OH  . TYR A 1 101 ? -0.37484  14.18437 -44.49225 1.000 22.45723 ? 101 TYR A OH  1 
ATOM   778  N N   . LYS A 1 102 ? 3.87960   15.83487 -39.72131 1.000 15.91840 ? 102 LYS A N   1 
ATOM   779  C CA  . LYS A 1 102 ? 3.70529   14.43703 -39.37904 1.000 17.85025 ? 102 LYS A CA  1 
ATOM   780  C C   . LYS A 1 102 ? 2.64625   14.34315 -38.29449 1.000 16.03765 ? 102 LYS A C   1 
ATOM   781  O O   . LYS A 1 102 ? 2.22687   15.34671 -37.71512 1.000 16.26060 ? 102 LYS A O   1 
ATOM   782  C CB  . LYS A 1 102 ? 5.01751   13.78558 -38.94012 1.000 29.33834 ? 102 LYS A CB  1 
ATOM   783  C CG  . LYS A 1 102 ? 5.62913   14.38387 -37.69596 1.000 33.44989 ? 102 LYS A CG  1 
ATOM   784  C CD  . LYS A 1 102 ? 6.97044   13.72027 -37.36709 1.000 33.65372 ? 102 LYS A CD  1 
ATOM   785  C CE  . LYS A 1 102 ? 7.95048   13.82403 -38.52231 1.000 47.00432 ? 102 LYS A CE  1 
ATOM   786  N NZ  . LYS A 1 102 ? 9.21568   13.08507 -38.24780 1.000 53.95954 ? 102 LYS A NZ  1 
ATOM   787  N N   . PHE A 1 103 ? 2.18784   13.12249 -38.06202 1.000 16.65314 ? 103 PHE A N   1 
ATOM   788  C CA  . PHE A 1 103 ? 1.26784   12.80928 -36.97924 1.000 14.47312 ? 103 PHE A CA  1 
ATOM   789  C C   . PHE A 1 103 ? 2.05673   12.11591 -35.88105 1.000 14.95720 ? 103 PHE A C   1 
ATOM   790  O O   . PHE A 1 103 ? 2.74197   11.12322 -36.13870 1.000 19.56870 ? 103 PHE A O   1 
ATOM   791  C CB  . PHE A 1 103 ? 0.13931   11.89517 -37.45512 1.000 13.29166 ? 103 PHE A CB  1 
ATOM   792  C CG  . PHE A 1 103 ? -0.84342  12.55023 -38.38258 1.000 15.53888 ? 103 PHE A CG  1 
ATOM   793  C CD1 . PHE A 1 103 ? -0.83040  13.91713 -38.58391 1.000 12.13924 ? 103 PHE A CD1 1 
ATOM   794  C CD2 . PHE A 1 103 ? -1.78902  11.78536 -39.03987 1.000 12.07219 ? 103 PHE A CD2 1 
ATOM   795  C CE1 . PHE A 1 103 ? -1.74555  14.51029 -39.42465 1.000 15.59108 ? 103 PHE A CE1 1 
ATOM   796  C CE2 . PHE A 1 103 ? -2.70873  12.36605 -39.88624 1.000 14.06293 ? 103 PHE A CE2 1 
ATOM   797  C CZ  . PHE A 1 103 ? -2.69233  13.73417 -40.07987 1.000 16.82923 ? 103 PHE A CZ  1 
ATOM   798  N N   . VAL A 1 104 ? 1.96434   12.63097 -34.66496 1.000 15.67235 ? 104 VAL A N   1 
ATOM   799  C CA  . VAL A 1 104 ? 2.67408   12.02801 -33.54977 1.000 15.28292 ? 104 VAL A CA  1 
ATOM   800  C C   . VAL A 1 104 ? 1.69592   11.82610 -32.40920 1.000 15.00700 ? 104 VAL A C   1 
ATOM   801  O O   . VAL A 1 104 ? 0.71910   12.56617 -32.25902 1.000 17.22133 ? 104 VAL A O   1 
ATOM   802  C CB  . VAL A 1 104 ? 3.87835   12.87691 -33.08562 1.000 18.06404 ? 104 VAL A CB  1 
ATOM   803  C CG1 . VAL A 1 104 ? 4.82940   13.14125 -34.24570 1.000 20.58691 ? 104 VAL A CG1 1 
ATOM   804  C CG2 . VAL A 1 104 ? 3.40695   14.17900 -32.46299 1.000 20.18328 ? 104 VAL A CG2 1 
ATOM   805  N N   . ARG A 1 105 ? 1.95803   10.80456 -31.61238 1.000 14.97097 ? 105 ARG A N   1 
ATOM   806  C CA  . ARG A 1 105 ? 1.26620   10.61640 -30.34971 1.000 17.57688 ? 105 ARG A CA  1 
ATOM   807  C C   . ARG A 1 105 ? 2.21390   11.03814 -29.23628 1.000 16.21041 ? 105 ARG A C   1 
ATOM   808  O O   . ARG A 1 105 ? 3.28270   10.44061 -29.06851 1.000 20.02684 ? 105 ARG A O   1 
ATOM   809  C CB  . ARG A 1 105 ? 0.82148   9.16489  -30.17554 1.000 21.53238 ? 105 ARG A CB  1 
ATOM   810  C CG  . ARG A 1 105 ? -0.12875  8.96974  -29.01092 1.000 15.28244 ? 105 ARG A CG  1 
ATOM   811  C CD  . ARG A 1 105 ? -0.67832  7.57557  -28.97645 1.000 17.31493 ? 105 ARG A CD  1 
ATOM   812  N NE  . ARG A 1 105 ? -1.50878  7.37544  -27.79421 1.000 15.91930 ? 105 ARG A NE  1 
ATOM   813  C CZ  . ARG A 1 105 ? -2.79788  7.67585  -27.71681 1.000 14.70664 ? 105 ARG A CZ  1 
ATOM   814  N NH1 . ARG A 1 105 ? -3.45153  8.20021  -28.74147 1.000 14.46034 ? 105 ARG A NH1 1 
ATOM   815  N NH2 . ARG A 1 105 ? -3.44609  7.44943  -26.57929 1.000 15.63479 ? 105 ARG A NH2 1 
ATOM   816  N N   . ILE A 1 106 ? 1.84777   12.06874 -28.49948 1.000 19.74951 ? 106 ILE A N   1 
ATOM   817  C CA  A ILE A 1 106 ? 2.72564   12.59551 -27.46672 0.500 20.30147 ? 106 ILE A CA  1 
ATOM   818  C CA  B ILE A 1 106 ? 2.73139   12.59072 -27.46838 0.500 20.30034 ? 106 ILE A CA  1 
ATOM   819  C C   . ILE A 1 106 ? 2.47484   11.84865 -26.16306 1.000 23.12721 ? 106 ILE A C   1 
ATOM   820  O O   . ILE A 1 106 ? 1.47120   11.14999 -25.99226 1.000 16.98749 ? 106 ILE A O   1 
ATOM   821  C CB  A ILE A 1 106 ? 2.55572   14.11845 -27.28209 0.500 20.92246 ? 106 ILE A CB  1 
ATOM   822  C CB  B ILE A 1 106 ? 2.57761   14.11436 -27.28118 0.500 20.92391 ? 106 ILE A CB  1 
ATOM   823  C CG1 A ILE A 1 106 ? 1.07471   14.49315 -27.23939 0.500 15.14231 ? 106 ILE A CG1 1 
ATOM   824  C CG1 B ILE A 1 106 ? 1.17130   14.46628 -26.79953 0.500 17.06198 ? 106 ILE A CG1 1 
ATOM   825  C CG2 A ILE A 1 106 ? 3.28035   14.87131 -28.39104 0.500 24.65208 ? 106 ILE A CG2 1 
ATOM   826  C CG2 B ILE A 1 106 ? 2.90955   14.84905 -28.57348 0.500 27.25293 ? 106 ILE A CG2 1 
ATOM   827  C CD1 A ILE A 1 106 ? 0.37992   14.13011 -25.94885 0.500 18.11124 ? 106 ILE A CD1 1 
ATOM   828  C CD1 B ILE A 1 106 ? 1.03317   15.91787 -26.38625 0.500 14.74707 ? 106 ILE A CD1 1 
ATOM   829  N N   . GLN A 1 107 ? 3.38425   11.99388 -25.25736 1.000 17.74639 ? 107 GLN A N   1 
ATOM   830  C CA  . GLN A 1 107 ? 3.40491   11.38888 -23.94904 1.000 20.55595 ? 107 GLN A CA  1 
ATOM   831  C C   . GLN A 1 107 ? 2.86417   12.35519 -22.90902 1.000 15.55127 ? 107 GLN A C   1 
ATOM   832  O O   . GLN A 1 107 ? 2.97412   13.57339 -23.06792 1.000 16.47534 ? 107 GLN A O   1 
ATOM   833  C CB  . GLN A 1 107 ? 4.83579   10.99390 -23.56046 1.000 22.44714 ? 107 GLN A CB  1 
ATOM   834  C CG  . GLN A 1 107 ? 5.49872   10.06827 -24.55221 1.000 34.07832 ? 107 GLN A CG  1 
ATOM   835  C CD  . GLN A 1 107 ? 4.89703   8.68518  -24.52088 1.000 41.12745 ? 107 GLN A CD  1 
ATOM   836  O OE1 . GLN A 1 107 ? 4.45248   8.21377  -23.47396 1.000 44.05756 ? 107 GLN A OE1 1 
ATOM   837  N NE2 . GLN A 1 107 ? 4.87324   8.02490  -25.67191 1.000 58.58123 ? 107 GLN A NE2 1 
ATOM   838  N N   . PRO A 1 108 ? 2.28107   11.83406 -21.83421 1.000 15.29409 ? 108 PRO A N   1 
ATOM   839  C CA  . PRO A 1 108 ? 1.88105   12.70876 -20.73098 1.000 18.17947 ? 108 PRO A CA  1 
ATOM   840  C C   . PRO A 1 108 ? 3.10006   13.44961 -20.20816 1.000 15.76875 ? 108 PRO A C   1 
ATOM   841  O O   . PRO A 1 108 ? 4.20234   12.89858 -20.13165 1.000 18.48512 ? 108 PRO A O   1 
ATOM   842  C CB  . PRO A 1 108 ? 1.30092   11.73920 -19.69297 1.000 21.22741 ? 108 PRO A CB  1 
ATOM   843  C CG  . PRO A 1 108 ? 1.86673   10.38840 -20.06785 1.000 23.45873 ? 108 PRO A CG  1 
ATOM   844  C CD  . PRO A 1 108 ? 2.02195   10.41150 -21.55253 1.000 27.09697 ? 108 PRO A CD  1 
ATOM   845  N N   . GLY A 1 109 ? 2.90208   14.72021 -19.88729 1.000 14.38564 ? 109 GLY A N   1 
ATOM   846  C CA  . GLY A 1 109 ? 3.96898   15.60642 -19.50144 1.000 14.17903 ? 109 GLY A CA  1 
ATOM   847  C C   . GLY A 1 109 ? 4.48393   16.48697 -20.62097 1.000 14.86087 ? 109 GLY A C   1 
ATOM   848  O O   . GLY A 1 109 ? 5.08446   17.52946 -20.34085 1.000 18.91376 ? 109 GLY A O   1 
ATOM   849  N N   . GLN A 1 110 ? 4.25957   16.10424 -21.87594 1.000 16.24600 ? 110 GLN A N   1 
ATOM   850  C CA  . GLN A 1 110 ? 4.72200   16.90785 -22.99448 1.000 16.64383 ? 110 GLN A CA  1 
ATOM   851  C C   . GLN A 1 110 ? 3.72203   18.01929 -23.30006 1.000 14.64763 ? 110 GLN A C   1 
ATOM   852  O O   . GLN A 1 110 ? 2.52242   17.89331 -23.04641 1.000 18.04634 ? 110 GLN A O   1 
ATOM   853  C CB  . GLN A 1 110 ? 4.95425   16.02075 -24.22022 1.000 14.59897 ? 110 GLN A CB  1 
ATOM   854  C CG  . GLN A 1 110 ? 6.07660   15.01280 -23.96430 1.000 21.91675 ? 110 GLN A CG  1 
ATOM   855  C CD  . GLN A 1 110 ? 6.42720   14.15310 -25.16505 1.000 35.54154 ? 110 GLN A CD  1 
ATOM   856  O OE1 . GLN A 1 110 ? 5.55257   13.67348 -25.89238 1.000 27.05528 ? 110 GLN A OE1 1 
ATOM   857  N NE2 . GLN A 1 110 ? 7.72493   13.94692 -25.37387 1.000 34.61409 ? 110 GLN A NE2 1 
ATOM   858  N N   . THR A 1 111 ? 4.23895   19.13089 -23.80683 1.000 12.47983 ? 111 THR A N   1 
ATOM   859  C CA  . THR A 1 111 ? 3.43900   20.30710 -24.11160 1.000 15.17664 ? 111 THR A CA  1 
ATOM   860  C C   . THR A 1 111 ? 3.20804   20.44226 -25.61205 1.000 11.71657 ? 111 THR A C   1 
ATOM   861  O O   . THR A 1 111 ? 3.89948   19.83721 -26.43779 1.000 14.42198 ? 111 THR A O   1 
ATOM   862  C CB  . THR A 1 111 ? 4.11777   21.57577 -23.59233 1.000 11.94943 ? 111 THR A CB  1 
ATOM   863  O OG1 . THR A 1 111 ? 5.45553   21.64106 -24.11019 1.000 15.16596 ? 111 THR A OG1 1 
ATOM   864  C CG2 . THR A 1 111 ? 4.13348   21.58787 -22.04877 1.000 14.09984 ? 111 THR A CG2 1 
ATOM   865  N N   . PHE A 1 112 ? 2.22319   21.26920 -25.95177 1.000 11.47358 ? 112 PHE A N   1 
ATOM   866  C CA  . PHE A 1 112 ? 1.91124   21.58992 -27.33815 1.000 12.33451 ? 112 PHE A CA  1 
ATOM   867  C C   . PHE A 1 112 ? 1.04649   22.84100 -27.35552 1.000 10.83379 ? 112 PHE A C   1 
ATOM   868  O O   . PHE A 1 112 ? 0.49716   23.25205 -26.32716 1.000 13.66222 ? 112 PHE A O   1 
ATOM   869  C CB  . PHE A 1 112 ? 1.21249   20.41964 -28.05722 1.000 11.42722 ? 112 PHE A CB  1 
ATOM   870  C CG  . PHE A 1 112 ? -0.04444  19.91360 -27.37247 1.000 14.01094 ? 112 PHE A CG  1 
ATOM   871  C CD1 . PHE A 1 112 ? 0.03034   18.95349 -26.37625 1.000 16.04787 ? 112 PHE A CD1 1 
ATOM   872  C CD2 . PHE A 1 112 ? -1.29401  20.37678 -27.75066 1.000 12.77789 ? 112 PHE A CD2 1 
ATOM   873  C CE1 . PHE A 1 112 ? -1.12092  18.46670 -25.75700 1.000 16.45526 ? 112 PHE A CE1 1 
ATOM   874  C CE2 . PHE A 1 112 ? -2.45140  19.89853 -27.13675 1.000 16.00824 ? 112 PHE A CE2 1 
ATOM   875  C CZ  . PHE A 1 112 ? -2.35914  18.94120 -26.13275 1.000 13.83031 ? 112 PHE A CZ  1 
ATOM   876  N N   . SER A 1 113 ? 0.94147   23.44717 -28.53571 1.000 10.37211 ? 113 SER A N   1 
ATOM   877  C CA  . SER A 1 113 ? 0.07243   24.59608 -28.74679 1.000 11.11336 ? 113 SER A CA  1 
ATOM   878  C C   . SER A 1 113 ? -1.26516  24.15795 -29.32572 1.000 12.86219 ? 113 SER A C   1 
ATOM   879  O O   . SER A 1 113 ? -1.33180  23.23887 -30.14517 1.000 14.48898 ? 113 SER A O   1 
ATOM   880  C CB  . SER A 1 113 ? 0.71236   25.61584 -29.68499 1.000 11.04564 ? 113 SER A CB  1 
ATOM   881  O OG  . SER A 1 113 ? 1.91578   26.11100 -29.13422 1.000 13.78397 ? 113 SER A OG  1 
ATOM   882  N N   . VAL A 1 114 ? -2.32576  24.83671 -28.90563 1.000 11.24515 ? 114 VAL A N   1 
ATOM   883  C CA  . VAL A 1 114 ? -3.67241  24.59965 -29.41342 1.000 11.03612 ? 114 VAL A CA  1 
ATOM   884  C C   . VAL A 1 114 ? -4.10683  25.83170 -30.19008 1.000 9.11017  ? 114 VAL A C   1 
ATOM   885  O O   . VAL A 1 114 ? -3.98487  26.95737 -29.69546 1.000 11.95499 ? 114 VAL A O   1 
ATOM   886  C CB  . VAL A 1 114 ? -4.66459  24.29661 -28.27471 1.000 12.11012 ? 114 VAL A CB  1 
ATOM   887  C CG1 . VAL A 1 114 ? -6.10125  24.31457 -28.79101 1.000 13.10199 ? 114 VAL A CG1 1 
ATOM   888  C CG2 . VAL A 1 114 ? -4.35446  22.94301 -27.63020 1.000 12.12058 ? 114 VAL A CG2 1 
ATOM   889  N N   . LEU A 1 115 ? -4.62583  25.62220 -31.39577 1.000 12.32162 ? 115 LEU A N   1 
ATOM   890  C CA  . LEU A 1 115 ? -5.25272  26.69277 -32.16371 1.000 10.09219 ? 115 LEU A CA  1 
ATOM   891  C C   . LEU A 1 115 ? -6.75697  26.47381 -32.05690 1.000 10.08597 ? 115 LEU A C   1 
ATOM   892  O O   . LEU A 1 115 ? -7.31946  25.60886 -32.73110 1.000 11.55838 ? 115 LEU A O   1 
ATOM   893  C CB  . LEU A 1 115 ? -4.76928  26.70190 -33.61045 1.000 14.24688 ? 115 LEU A CB  1 
ATOM   894  C CG  . LEU A 1 115 ? -5.40164  27.78657 -34.49576 1.000 12.31700 ? 115 LEU A CG  1 
ATOM   895  C CD1 . LEU A 1 115 ? -4.94661  29.17481 -34.08778 1.000 13.39447 ? 115 LEU A CD1 1 
ATOM   896  C CD2 . LEU A 1 115 ? -5.06940  27.51686 -35.95825 1.000 13.33195 ? 115 LEU A CD2 1 
ATOM   897  N N   . ALA A 1 116 ? -7.39079  27.21355 -31.15640 1.000 11.21058 ? 116 ALA A N   1 
ATOM   898  C CA  . ALA A 1 116 ? -8.82296  27.07373 -30.94854 1.000 12.06619 ? 116 ALA A CA  1 
ATOM   899  C C   . ALA A 1 116 ? -9.56626  27.69532 -32.12301 1.000 11.81854 ? 116 ALA A C   1 
ATOM   900  O O   . ALA A 1 116 ? -9.33253  28.85856 -32.46542 1.000 15.43268 ? 116 ALA A O   1 
ATOM   901  C CB  . ALA A 1 116 ? -9.23186  27.74180 -29.63640 1.000 14.09750 ? 116 ALA A CB  1 
ATOM   902  N N   . CYS A 1 117 ? -10.46654 26.92080 -32.73437 1.000 12.66876 ? 117 CYS A N   1 
ATOM   903  C CA  . CYS A 1 117 ? -11.19047 27.33679 -33.92599 1.000 14.70694 ? 117 CYS A CA  1 
ATOM   904  C C   . CYS A 1 117 ? -12.68589 27.11021 -33.76413 1.000 10.65675 ? 117 CYS A C   1 
ATOM   905  O O   . CYS A 1 117 ? -13.11918 26.19453 -33.06012 1.000 13.96923 ? 117 CYS A O   1 
ATOM   906  C CB  . CYS A 1 117 ? -10.71511 26.56871 -35.15656 1.000 15.22769 ? 117 CYS A CB  1 
ATOM   907  S SG  . CYS A 1 117 ? -9.02437  26.91315 -35.57785 1.000 16.02757 ? 117 CYS A SG  1 
ATOM   908  N N   . TYR A 1 118 ? -13.46090 27.93979 -34.46415 1.000 14.05193 ? 118 TYR A N   1 
ATOM   909  C CA  . TYR A 1 118 ? -14.90699 27.79625 -34.58323 1.000 14.01099 ? 118 TYR A CA  1 
ATOM   910  C C   . TYR A 1 118 ? -15.28472 28.05754 -36.03053 1.000 13.36067 ? 118 TYR A C   1 
ATOM   911  O O   . TYR A 1 118 ? -14.80961 29.02544 -36.63010 1.000 14.28823 ? 118 TYR A O   1 
ATOM   912  C CB  . TYR A 1 118 ? -15.64128 28.75844 -33.63085 1.000 15.63653 ? 118 TYR A CB  1 
ATOM   913  C CG  . TYR A 1 118 ? -15.24874 28.48204 -32.20408 1.000 14.23987 ? 118 TYR A CG  1 
ATOM   914  C CD1 . TYR A 1 118 ? -14.14389 29.09986 -31.63822 1.000 19.78193 ? 118 TYR A CD1 1 
ATOM   915  C CD2 . TYR A 1 118 ? -15.94748 27.55248 -31.44201 1.000 14.63708 ? 118 TYR A CD2 1 
ATOM   916  C CE1 . TYR A 1 118 ? -13.74839 28.80568 -30.34141 1.000 13.67948 ? 118 TYR A CE1 1 
ATOM   917  C CE2 . TYR A 1 118 ? -15.56571 27.25918 -30.15168 1.000 18.26601 ? 118 TYR A CE2 1 
ATOM   918  C CZ  . TYR A 1 118 ? -14.47108 27.89059 -29.60609 1.000 12.92305 ? 118 TYR A CZ  1 
ATOM   919  O OH  . TYR A 1 118 ? -14.06402 27.59871 -28.32136 1.000 15.67849 ? 118 TYR A OH  1 
ATOM   920  N N   . ASN A 1 119 ? -16.12019 27.18151 -36.59108 1.000 15.14196 ? 119 ASN A N   1 
ATOM   921  C CA  . ASN A 1 119 ? -16.58615 27.32521 -37.96740 1.000 16.36469 ? 119 ASN A CA  1 
ATOM   922  C C   . ASN A 1 119 ? -15.41927 27.47070 -38.94016 1.000 15.07868 ? 119 ASN A C   1 
ATOM   923  O O   . ASN A 1 119 ? -15.49113 28.20119 -39.92775 1.000 18.12440 ? 119 ASN A O   1 
ATOM   924  C CB  . ASN A 1 119 ? -17.54589 28.50980 -38.09648 1.000 16.48687 ? 119 ASN A CB  1 
ATOM   925  C CG  . ASN A 1 119 ? -18.75246 28.37088 -37.20380 1.000 23.13294 ? 119 ASN A CG  1 
ATOM   926  O OD1 . ASN A 1 119 ? -18.96378 29.17799 -36.30378 1.000 32.52488 ? 119 ASN A OD1 1 
ATOM   927  N ND2 . ASN A 1 119 ? -19.54578 27.33527 -37.43837 1.000 26.29914 ? 119 ASN A ND2 1 
ATOM   928  N N   . GLY A 1 120 ? -14.33018 26.76466 -38.65961 1.000 14.64458 ? 120 GLY A N   1 
ATOM   929  C CA  . GLY A 1 120 ? -13.18189 26.76558 -39.53857 1.000 13.65331 ? 120 GLY A CA  1 
ATOM   930  C C   . GLY A 1 120 ? -12.29777 27.98590 -39.44136 1.000 15.93699 ? 120 GLY A C   1 
ATOM   931  O O   . GLY A 1 120 ? -11.34712 28.09798 -40.21868 1.000 16.89627 ? 120 GLY A O   1 
ATOM   932  N N   . SER A 1 121 ? -12.57289 28.89710 -38.51091 1.000 18.66622 ? 121 SER A N   1 
ATOM   933  C CA  A SER A 1 121 ? -11.82539 30.13179 -38.36691 0.500 16.04862 ? 121 SER A CA  1 
ATOM   934  C CA  B SER A 1 121 ? -11.81786 30.12464 -38.37001 0.500 16.01979 ? 121 SER A CA  1 
ATOM   935  C C   . SER A 1 121 ? -11.12581 30.16923 -37.01542 1.000 11.41580 ? 121 SER A C   1 
ATOM   936  O O   . SER A 1 121 ? -11.72156 29.79660 -36.00148 1.000 16.80848 ? 121 SER A O   1 
ATOM   937  C CB  A SER A 1 121 ? -12.75411 31.35317 -38.49557 0.500 18.51280 ? 121 SER A CB  1 
ATOM   938  C CB  B SER A 1 121 ? -12.73580 31.34820 -38.52176 0.500 18.57140 ? 121 SER A CB  1 
ATOM   939  O OG  A SER A 1 121 ? -12.01459 32.55878 -38.40150 0.500 26.65486 ? 121 SER A OG  1 
ATOM   940  O OG  B SER A 1 121 ? -13.16108 31.48784 -39.86552 0.500 15.32505 ? 121 SER A OG  1 
ATOM   941  N N   . PRO A 1 122 ? -9.87696  30.61969 -36.96631 1.000 15.94636 ? 122 PRO A N   1 
ATOM   942  C CA  . PRO A 1 122 ? -9.13349  30.59372 -35.70411 1.000 17.88224 ? 122 PRO A CA  1 
ATOM   943  C C   . PRO A 1 122 ? -9.58110  31.69685 -34.75896 1.000 22.24812 ? 122 PRO A C   1 
ATOM   944  O O   . PRO A 1 122 ? -9.79852  32.84032 -35.16212 1.000 23.48976 ? 122 PRO A O   1 
ATOM   945  C CB  . PRO A 1 122 ? -7.68660  30.80657 -36.15674 1.000 20.74709 ? 122 PRO A CB  1 
ATOM   946  C CG  . PRO A 1 122 ? -7.82388  31.66826 -37.36629 1.000 24.19675 ? 122 PRO A CG  1 
ATOM   947  C CD  . PRO A 1 122 ? -9.09018  31.20980 -38.06296 1.000 24.58189 ? 122 PRO A CD  1 
ATOM   948  N N   . SER A 1 123 ? -9.71245  31.33813 -33.48330 1.000 17.52400 ? 123 SER A N   1 
ATOM   949  C CA  . SER A 1 123 ? -10.05117 32.26560 -32.41037 1.000 15.76480 ? 123 SER A CA  1 
ATOM   950  C C   . SER A 1 123 ? -8.83725  32.68214 -31.58268 1.000 14.98746 ? 123 SER A C   1 
ATOM   951  O O   . SER A 1 123 ? -8.73621  33.84669 -31.18147 1.000 20.01454 ? 123 SER A O   1 
ATOM   952  C CB  . SER A 1 123 ? -11.10532 31.63368 -31.49312 1.000 21.84044 ? 123 SER A CB  1 
ATOM   953  O OG  . SER A 1 123 ? -11.47351 32.50297 -30.43542 1.000 29.02539 ? 123 SER A OG  1 
ATOM   954  N N   . GLY A 1 124 ? -7.91702  31.76332 -31.30759 1.000 18.32472 ? 124 GLY A N   1 
ATOM   955  C CA  . GLY A 1 124 ? -6.76476  32.09466 -30.48260 1.000 13.64303 ? 124 GLY A CA  1 
ATOM   956  C C   . GLY A 1 124 ? -5.84301  30.90111 -30.37586 1.000 12.81817 ? 124 GLY A C   1 
ATOM   957  O O   . GLY A 1 124 ? -6.19025  29.78223 -30.76358 1.000 14.73381 ? 124 GLY A O   1 
ATOM   958  N N   . VAL A 1 125 ? -4.65665  31.15123 -29.82427 1.000 11.11029 ? 125 VAL A N   1 
ATOM   959  C CA  . VAL A 1 125 ? -3.65441  30.10789 -29.65209 1.000 11.15866 ? 125 VAL A CA  1 
ATOM   960  C C   . VAL A 1 125 ? -3.14349  30.14542 -28.21905 1.000 15.92860 ? 125 VAL A C   1 
ATOM   961  O O   . VAL A 1 125 ? -2.92343  31.22009 -27.64778 1.000 15.39201 ? 125 VAL A O   1 
ATOM   962  C CB  . VAL A 1 125 ? -2.49515  30.24167 -30.66957 1.000 19.24610 ? 125 VAL A CB  1 
ATOM   963  C CG1 . VAL A 1 125 ? -1.75376  31.55694 -30.50233 1.000 27.14744 ? 125 VAL A CG1 1 
ATOM   964  C CG2 . VAL A 1 125 ? -1.54339  29.06314 -30.55888 1.000 14.87481 ? 125 VAL A CG2 1 
ATOM   965  N N   . TYR A 1 126 ? -2.99564  28.96846 -27.62310 1.000 12.58863 ? 126 TYR A N   1 
ATOM   966  C CA  . TYR A 1 126 ? -2.42605  28.89410 -26.29187 1.000 16.54748 ? 126 TYR A CA  1 
ATOM   967  C C   . TYR A 1 126 ? -1.62914  27.60949 -26.15108 1.000 16.57017 ? 126 TYR A C   1 
ATOM   968  O O   . TYR A 1 126 ? -1.75335  26.67850 -26.94558 1.000 14.95057 ? 126 TYR A O   1 
ATOM   969  C CB  . TYR A 1 126 ? -3.50373  28.98890 -25.21020 1.000 14.11340 ? 126 TYR A CB  1 
ATOM   970  C CG  . TYR A 1 126 ? -4.64768  28.02791 -25.38872 1.000 15.12521 ? 126 TYR A CG  1 
ATOM   971  C CD1 . TYR A 1 126 ? -4.60062  26.75858 -24.83256 1.000 17.58465 ? 126 TYR A CD1 1 
ATOM   972  C CD2 . TYR A 1 126 ? -5.77456  28.39190 -26.10618 1.000 17.59767 ? 126 TYR A CD2 1 
ATOM   973  C CE1 . TYR A 1 126 ? -5.65097  25.87729 -24.98402 1.000 22.67265 ? 126 TYR A CE1 1 
ATOM   974  C CE2 . TYR A 1 126 ? -6.83278  27.51963 -26.25886 1.000 17.75020 ? 126 TYR A CE2 1 
ATOM   975  C CZ  . TYR A 1 126 ? -6.76117  26.26271 -25.69675 1.000 24.81392 ? 126 TYR A CZ  1 
ATOM   976  O OH  . TYR A 1 126 ? -7.80915  25.38783 -25.84981 1.000 20.43640 ? 126 TYR A OH  1 
ATOM   977  N N   . GLN A 1 127 ? -0.80511  27.57996 -25.11651 1.000 16.43930 ? 127 GLN A N   1 
ATOM   978  C CA  . GLN A 1 127 ? 0.10123   26.47897 -24.84049 1.000 13.97712 ? 127 GLN A CA  1 
ATOM   979  C C   . GLN A 1 127 ? -0.47016  25.64482 -23.70453 1.000 18.74897 ? 127 GLN A C   1 
ATOM   980  O O   . GLN A 1 127 ? -1.00875  26.19164 -22.73873 1.000 17.79987 ? 127 GLN A O   1 
ATOM   981  C CB  . GLN A 1 127 ? 1.48010   27.02444 -24.45624 1.000 16.46391 ? 127 GLN A CB  1 
ATOM   982  C CG  . GLN A 1 127 ? 2.55142   25.99132 -24.24771 1.000 21.88916 ? 127 GLN A CG  1 
ATOM   983  C CD  . GLN A 1 127 ? 3.09890   25.46316 -25.55201 1.000 16.90192 ? 127 GLN A CD  1 
ATOM   984  O OE1 . GLN A 1 127 ? 2.61207   25.81722 -26.63567 1.000 17.29169 ? 127 GLN A OE1 1 
ATOM   985  N NE2 . GLN A 1 127 ? 4.11214   24.60614 -25.46209 1.000 18.69603 ? 127 GLN A NE2 1 
ATOM   986  N N   . CYS A 1 128 ? -0.36175  24.32290 -23.81608 1.000 19.56105 ? 128 CYS A N   1 
ATOM   987  C CA  . CYS A 1 128 ? -0.84214  23.46950 -22.73506 1.000 19.42284 ? 128 CYS A CA  1 
ATOM   988  C C   . CYS A 1 128 ? -0.00633  22.19772 -22.67345 1.000 12.11450 ? 128 CYS A C   1 
ATOM   989  O O   . CYS A 1 128 ? 0.90316   21.98241 -23.47576 1.000 17.26124 ? 128 CYS A O   1 
ATOM   990  C CB  . CYS A 1 128 ? -2.31862  23.14816 -22.90511 1.000 19.23134 ? 128 CYS A CB  1 
ATOM   991  S SG  . CYS A 1 128 ? -2.65743  22.21479 -24.38745 1.000 30.77466 ? 128 CYS A SG  1 
ATOM   992  N N   . ALA A 1 129 ? -0.30467  21.36633 -21.68404 1.000 15.66582 ? 129 ALA A N   1 
ATOM   993  C CA  . ALA A 1 129 ? 0.39392   20.10835 -21.47664 1.000 13.15873 ? 129 ALA A CA  1 
ATOM   994  C C   . ALA A 1 129 ? -0.59429  18.95651 -21.47241 1.000 16.41940 ? 129 ALA A C   1 
ATOM   995  O O   . ALA A 1 129 ? -1.71552  19.08661 -20.97246 1.000 15.69270 ? 129 ALA A O   1 
ATOM   996  C CB  . ALA A 1 129 ? 1.16658   20.10564 -20.16011 1.000 15.64311 ? 129 ALA A CB  1 
ATOM   997  N N   . MET A 1 130 ? -0.17652  17.82434 -22.02547 1.000 15.86622 ? 130 MET A N   1 
ATOM   998  C CA  . MET A 1 130 ? -0.91138  16.58298 -21.80265 1.000 11.97952 ? 130 MET A CA  1 
ATOM   999  C C   . MET A 1 130 ? -0.71064  16.18152 -20.34840 1.000 16.95680 ? 130 MET A C   1 
ATOM   1000 O O   . MET A 1 130 ? 0.41370   15.87519 -19.94366 1.000 16.05461 ? 130 MET A O   1 
ATOM   1001 C CB  . MET A 1 130 ? -0.41784  15.49730 -22.75531 1.000 15.59244 ? 130 MET A CB  1 
ATOM   1002 C CG  . MET A 1 130 ? -1.11578  14.14784 -22.62736 1.000 15.47226 ? 130 MET A CG  1 
ATOM   1003 S SD  . MET A 1 130 ? -2.90706  14.23717 -22.83779 1.000 15.68273 ? 130 MET A SD  1 
ATOM   1004 C CE  . MET A 1 130 ? -3.03223  14.68021 -24.56850 1.000 15.17349 ? 130 MET A CE  1 
ATOM   1005 N N   . ARG A 1 131 ? -1.77991  16.23366 -19.54940 1.000 14.84880 ? 131 ARG A N   1 
ATOM   1006 C CA  . ARG A 1 131 ? -1.65593  15.94610 -18.12974 1.000 12.76590 ? 131 ARG A CA  1 
ATOM   1007 C C   . ARG A 1 131 ? -1.40301  14.45978 -17.91172 1.000 13.45723 ? 131 ARG A C   1 
ATOM   1008 O O   . ARG A 1 131 ? -1.70904  13.63436 -18.77638 1.000 14.58082 ? 131 ARG A O   1 
ATOM   1009 C CB  . ARG A 1 131 ? -2.91343  16.35528 -17.36941 1.000 16.30844 ? 131 ARG A CB  1 
ATOM   1010 C CG  . ARG A 1 131 ? -3.33765  17.80022 -17.52860 1.000 15.35529 ? 131 ARG A CG  1 
ATOM   1011 C CD  . ARG A 1 131 ? -2.24188  18.76442 -17.08625 1.000 19.80584 ? 131 ARG A CD  1 
ATOM   1012 N NE  . ARG A 1 131 ? -1.72893  18.45398 -15.75688 1.000 15.53589 ? 131 ARG A NE  1 
ATOM   1013 C CZ  . ARG A 1 131 ? -0.71535  19.09155 -15.19053 1.000 15.98711 ? 131 ARG A CZ  1 
ATOM   1014 N NH1 . ARG A 1 131 ? -0.11085  20.10049 -15.79690 1.000 14.01304 ? 131 ARG A NH1 1 
ATOM   1015 N NH2 . ARG A 1 131 ? -0.29158  18.70115 -13.99104 1.000 13.08297 ? 131 ARG A NH2 1 
ATOM   1016 N N   . PRO A 1 132 ? -0.85795  14.09354 -16.75046 1.000 15.04262 ? 132 PRO A N   1 
ATOM   1017 C CA  . PRO A 1 132 ? -0.69078  12.66643 -16.44446 1.000 13.00664 ? 132 PRO A CA  1 
ATOM   1018 C C   . PRO A 1 132 ? -1.99582  11.88589 -16.47837 1.000 17.16465 ? 132 PRO A C   1 
ATOM   1019 O O   . PRO A 1 132 ? -1.96780  10.67463 -16.73616 1.000 16.16264 ? 132 PRO A O   1 
ATOM   1020 C CB  . PRO A 1 132 ? -0.06231  12.68904 -15.04423 1.000 15.06416 ? 132 PRO A CB  1 
ATOM   1021 C CG  . PRO A 1 132 ? 0.69170   13.97173 -15.01599 1.000 14.52961 ? 132 PRO A CG  1 
ATOM   1022 C CD  . PRO A 1 132 ? -0.19235  14.94918 -15.75190 1.000 15.65918 ? 132 PRO A CD  1 
ATOM   1023 N N   . ASN A 1 133 ? -3.13926  12.53268 -16.24379 1.000 13.92706 ? 133 ASN A N   1 
ATOM   1024 C CA  . ASN A 1 133 ? -4.42545  11.85278 -16.35067 1.000 14.45257 ? 133 ASN A CA  1 
ATOM   1025 C C   . ASN A 1 133 ? -5.02045  11.92148 -17.75590 1.000 15.80191 ? 133 ASN A C   1 
ATOM   1026 O O   . ASN A 1 133 ? -6.19249  11.57409 -17.93899 1.000 17.19951 ? 133 ASN A O   1 
ATOM   1027 C CB  . ASN A 1 133 ? -5.41099  12.41093 -15.31646 1.000 17.33778 ? 133 ASN A CB  1 
ATOM   1028 C CG  . ASN A 1 133 ? -5.84076  13.83258 -15.61241 1.000 17.14331 ? 133 ASN A CG  1 
ATOM   1029 O OD1 . ASN A 1 133 ? -5.40786  14.43905 -16.59479 1.000 16.40730 ? 133 ASN A OD1 1 
ATOM   1030 N ND2 . ASN A 1 133 ? -6.72701  14.36763 -14.76770 1.000 15.16765 ? 133 ASN A ND2 1 
ATOM   1031 N N   . PHE A 1 134 ? -4.23780  12.35052 -18.74817 1.000 14.62696 ? 134 PHE A N   1 
ATOM   1032 C CA  . PHE A 1 134 ? -4.59258  12.28699 -20.16447 1.000 15.18938 ? 134 PHE A CA  1 
ATOM   1033 C C   . PHE A 1 134 ? -5.69483  13.26459 -20.55113 1.000 17.22117 ? 134 PHE A C   1 
ATOM   1034 O O   . PHE A 1 134 ? -6.42207  13.03269 -21.52462 1.000 20.67807 ? 134 PHE A O   1 
ATOM   1035 C CB  . PHE A 1 134 ? -4.96853  10.85617 -20.56733 1.000 15.68360 ? 134 PHE A CB  1 
ATOM   1036 C CG  . PHE A 1 134 ? -3.80231  9.90268  -20.54540 1.000 20.24506 ? 134 PHE A CG  1 
ATOM   1037 C CD1 . PHE A 1 134 ? -2.82007  9.96668  -21.52482 1.000 23.60258 ? 134 PHE A CD1 1 
ATOM   1038 C CD2 . PHE A 1 134 ? -3.68144  8.95808  -19.54356 1.000 31.90236 ? 134 PHE A CD2 1 
ATOM   1039 C CE1 . PHE A 1 134 ? -1.74641  9.09290  -21.50992 1.000 32.96837 ? 134 PHE A CE1 1 
ATOM   1040 C CE2 . PHE A 1 134 ? -2.60952  8.08630  -19.51751 1.000 26.92723 ? 134 PHE A CE2 1 
ATOM   1041 C CZ  . PHE A 1 134 ? -1.64066  8.15311  -20.50331 1.000 22.06676 ? 134 PHE A CZ  1 
ATOM   1042 N N   . THR A 1 135 ? -5.84401  14.34362 -19.79802 1.000 13.96281 ? 135 THR A N   1 
ATOM   1043 C CA  . THR A 1 135 ? -6.64809  15.49072 -20.18184 1.000 13.88599 ? 135 THR A CA  1 
ATOM   1044 C C   . THR A 1 135 ? -5.71526  16.66069 -20.45087 1.000 17.58024 ? 135 THR A C   1 
ATOM   1045 O O   . THR A 1 135 ? -4.51927  16.61581 -20.13985 1.000 15.27944 ? 135 THR A O   1 
ATOM   1046 C CB  . THR A 1 135 ? -7.64733  15.85496 -19.08159 1.000 14.95915 ? 135 THR A CB  1 
ATOM   1047 O OG1 . THR A 1 135 ? -6.92577  16.30862 -17.92921 1.000 17.56829 ? 135 THR A OG1 1 
ATOM   1048 C CG2 . THR A 1 135 ? -8.47999  14.63815 -18.69469 1.000 15.23222 ? 135 THR A CG2 1 
ATOM   1049 N N   . ILE A 1 136 ? -6.26644  17.71121 -21.04698 1.000 13.79274 ? 136 ILE A N   1 
ATOM   1050 C CA  . ILE A 1 136 ? -5.57196  18.98912 -21.10315 1.000 13.59964 ? 136 ILE A CA  1 
ATOM   1051 C C   . ILE A 1 136 ? -6.44071  20.05148 -20.44574 1.000 13.36987 ? 136 ILE A C   1 
ATOM   1052 O O   . ILE A 1 136 ? -7.67631  19.97055 -20.43201 1.000 14.82615 ? 136 ILE A O   1 
ATOM   1053 C CB  . ILE A 1 136 ? -5.18725  19.40676 -22.53932 1.000 14.61745 ? 136 ILE A CB  1 
ATOM   1054 C CG1 . ILE A 1 136 ? -6.42444  19.73295 -23.38651 1.000 14.68076 ? 136 ILE A CG1 1 
ATOM   1055 C CG2 . ILE A 1 136 ? -4.34301  18.32919 -23.18779 1.000 15.40800 ? 136 ILE A CG2 1 
ATOM   1056 C CD1 . ILE A 1 136 ? -6.06393  20.09024 -24.83339 1.000 17.01634 ? 136 ILE A CD1 1 
ATOM   1057 N N   . LYS A 1 137 ? -5.77569  21.04679 -19.87226 1.000 15.59160 ? 137 LYS A N   1 
ATOM   1058 C CA  . LYS A 1 137 ? -6.46021  22.20657 -19.30407 1.000 13.95141 ? 137 LYS A CA  1 
ATOM   1059 C C   . LYS A 1 137 ? -6.56652  23.24203 -20.41314 1.000 16.89439 ? 137 LYS A C   1 
ATOM   1060 O O   . LYS A 1 137 ? -5.70377  24.10545 -20.57202 1.000 15.68150 ? 137 LYS A O   1 
ATOM   1061 C CB  . LYS A 1 137 ? -5.71512  22.74258 -18.08805 1.000 17.47169 ? 137 LYS A CB  1 
ATOM   1062 C CG  . LYS A 1 137 ? -5.65925  21.76921 -16.92220 1.000 23.26040 ? 137 LYS A CG  1 
ATOM   1063 C CD  . LYS A 1 137 ? -4.77662  22.29958 -15.79504 1.000 37.67466 ? 137 LYS A CD  1 
ATOM   1064 C CE  . LYS A 1 137 ? -4.52606  21.22673 -14.74380 1.000 29.71539 ? 137 LYS A CE  1 
ATOM   1065 N NZ  . LYS A 1 137 ? -3.50498  21.63438 -13.73678 1.000 31.85017 ? 137 LYS A NZ  1 
ATOM   1066 N N   . GLY A 1 138 ? -7.64420  23.15387 -21.19639 1.000 13.64736 ? 138 GLY A N   1 
ATOM   1067 C CA  . GLY A 1 138 ? -7.84192  24.01363 -22.33578 1.000 16.06658 ? 138 GLY A CA  1 
ATOM   1068 C C   . GLY A 1 138 ? -8.90730  25.06935 -22.11264 1.000 12.21967 ? 138 GLY A C   1 
ATOM   1069 O O   . GLY A 1 138 ? -9.36984  25.31905 -20.99528 1.000 14.39531 ? 138 GLY A O   1 
ATOM   1070 N N   . SER A 1 139 ? -9.28782  25.70264 -23.21940 1.000 11.70189 ? 139 SER A N   1 
ATOM   1071 C CA  . SER A 1 139 ? -10.36873 26.68854 -23.24687 1.000 12.58564 ? 139 SER A CA  1 
ATOM   1072 C C   . SER A 1 139 ? -11.13890 26.43241 -24.53834 1.000 12.76073 ? 139 SER A C   1 
ATOM   1073 O O   . SER A 1 139 ? -10.67587 26.79721 -25.62515 1.000 14.47187 ? 139 SER A O   1 
ATOM   1074 C CB  . SER A 1 139 ? -9.81397  28.10984 -23.17491 1.000 13.06532 ? 139 SER A CB  1 
ATOM   1075 O OG  . SER A 1 139 ? -10.85549 29.07346 -23.26564 1.000 15.18530 ? 139 SER A OG  1 
ATOM   1076 N N   . PHE A 1 140 ? -12.29814 25.78719 -24.41797 1.000 14.68595 ? 140 PHE A N   1 
ATOM   1077 C CA  . PHE A 1 140 ? -13.03665 25.29341 -25.57149 1.000 11.21110 ? 140 PHE A CA  1 
ATOM   1078 C C   . PHE A 1 140 ? -14.52800 25.46808 -25.32887 1.000 15.89524 ? 140 PHE A C   1 
ATOM   1079 O O   . PHE A 1 140 ? -15.01418 25.18343 -24.23067 1.000 17.76117 ? 140 PHE A O   1 
ATOM   1080 C CB  . PHE A 1 140 ? -12.77235 23.79892 -25.82102 1.000 11.06233 ? 140 PHE A CB  1 
ATOM   1081 C CG  . PHE A 1 140 ? -11.38300 23.46186 -26.30128 1.000 13.20584 ? 140 PHE A CG  1 
ATOM   1082 C CD1 . PHE A 1 140 ? -10.99300 23.73781 -27.59845 1.000 18.66547 ? 140 PHE A CD1 1 
ATOM   1083 C CD2 . PHE A 1 140 ? -10.49969 22.78855 -25.47234 1.000 13.56045 ? 140 PHE A CD2 1 
ATOM   1084 C CE1 . PHE A 1 140 ? -9.72279  23.39179 -28.04508 1.000 17.75711 ? 140 PHE A CE1 1 
ATOM   1085 C CE2 . PHE A 1 140 ? -9.22966  22.43081 -25.91363 1.000 17.28660 ? 140 PHE A CE2 1 
ATOM   1086 C CZ  . PHE A 1 140 ? -8.84488  22.73215 -27.19666 1.000 16.91919 ? 140 PHE A CZ  1 
ATOM   1087 N N   . LEU A 1 141 ? -15.25304 25.88249 -26.36453 1.000 14.24851 ? 141 LEU A N   1 
ATOM   1088 C CA  . LEU A 1 141 ? -16.70045 26.07544 -26.31051 1.000 15.19780 ? 141 LEU A CA  1 
ATOM   1089 C C   . LEU A 1 141 ? -17.38509 25.13396 -27.29747 1.000 15.31450 ? 141 LEU A C   1 
ATOM   1090 O O   . LEU A 1 141 ? -16.73956 24.34619 -27.99659 1.000 16.77073 ? 141 LEU A O   1 
ATOM   1091 C CB  . LEU A 1 141 ? -17.06609 27.52904 -26.61927 1.000 12.27217 ? 141 LEU A CB  1 
ATOM   1092 C CG  . LEU A 1 141 ? -16.34380 28.59631 -25.79963 1.000 17.27039 ? 141 LEU A CG  1 
ATOM   1093 C CD1 . LEU A 1 141 ? -16.49779 29.95900 -26.46041 1.000 16.97745 ? 141 LEU A CD1 1 
ATOM   1094 C CD2 . LEU A 1 141 ? -16.86945 28.63107 -24.37312 1.000 14.71833 ? 141 LEU A CD2 1 
ATOM   1095 N N   . ASN A 1 142 ? -18.71526 25.22319 -27.35949 1.000 14.44629 ? 142 ASN A N   1 
ATOM   1096 C CA  . ASN A 1 142 ? -19.44646 24.53837 -28.41666 1.000 13.42238 ? 142 ASN A CA  1 
ATOM   1097 C C   . ASN A 1 142 ? -18.86717 24.89298 -29.77929 1.000 14.24040 ? 142 ASN A C   1 
ATOM   1098 O O   . ASN A 1 142 ? -18.56436 26.05492 -30.06212 1.000 16.59549 ? 142 ASN A O   1 
ATOM   1099 C CB  . ASN A 1 142 ? -20.92789 24.91666 -28.36815 1.000 16.41017 ? 142 ASN A CB  1 
ATOM   1100 C CG  . ASN A 1 142 ? -21.64929 24.27502 -27.21125 1.000 25.40412 ? 142 ASN A CG  1 
ATOM   1101 O OD1 . ASN A 1 142 ? -21.20409 23.26173 -26.67123 1.000 26.60777 ? 142 ASN A OD1 1 
ATOM   1102 N ND2 . ASN A 1 142 ? -22.78030 24.85967 -26.82275 1.000 25.46148 ? 142 ASN A ND2 1 
ATOM   1103 N N   . GLY A 1 143 ? -18.72803 23.87909 -30.62899 1.000 12.54832 ? 143 GLY A N   1 
ATOM   1104 C CA  . GLY A 1 143 ? -18.20849 24.07880 -31.96501 1.000 14.19306 ? 143 GLY A CA  1 
ATOM   1105 C C   . GLY A 1 143 ? -16.70046 24.08782 -32.07205 1.000 12.84188 ? 143 GLY A C   1 
ATOM   1106 O O   . GLY A 1 143 ? -16.17569 24.24940 -33.18174 1.000 14.28244 ? 143 GLY A O   1 
ATOM   1107 N N   . SER A 1 144 ? -15.98095 23.93004 -30.96135 1.000 13.61294 ? 144 SER A N   1 
ATOM   1108 C CA  . SER A 1 144 ? -14.52340 23.93521 -31.01139 1.000 12.70213 ? 144 SER A CA  1 
ATOM   1109 C C   . SER A 1 144 ? -13.92534 22.61821 -31.48939 1.000 13.00057 ? 144 SER A C   1 
ATOM   1110 O O   . SER A 1 144 ? -12.71838 22.56944 -31.75324 1.000 13.65837 ? 144 SER A O   1 
ATOM   1111 C CB  . SER A 1 144 ? -13.95874 24.25411 -29.62434 1.000 10.31160 ? 144 SER A CB  1 
ATOM   1112 O OG  . SER A 1 144 ? -14.31606 23.24040 -28.69864 1.000 16.07340 ? 144 SER A OG  1 
ATOM   1113 N N   . CYS A 1 145 ? -14.72132 21.55513 -31.59416 1.000 12.57925 ? 145 CYS A N   1 
ATOM   1114 C CA  . CYS A 1 145 ? -14.16175 20.24543 -31.89738 1.000 12.79992 ? 145 CYS A CA  1 
ATOM   1115 C C   . CYS A 1 145 ? -13.52494 20.24218 -33.27861 1.000 9.48937  ? 145 CYS A C   1 
ATOM   1116 O O   . CYS A 1 145 ? -13.99006 20.90810 -34.20712 1.000 13.95582 ? 145 CYS A O   1 
ATOM   1117 C CB  . CYS A 1 145 ? -15.24549 19.17357 -31.81142 1.000 14.01434 ? 145 CYS A CB  1 
ATOM   1118 S SG  . CYS A 1 145 ? -15.65436 18.76578 -30.11444 1.000 15.85875 ? 145 CYS A SG  1 
ATOM   1119 N N   . GLY A 1 146 ? -12.44038 19.47894 -33.41000 1.000 10.69709 ? 146 GLY A N   1 
ATOM   1120 C CA  . GLY A 1 146 ? -11.61971 19.53154 -34.59418 1.000 10.62143 ? 146 GLY A CA  1 
ATOM   1121 C C   . GLY A 1 146 ? -10.47600 20.51688 -34.53377 1.000 14.60158 ? 146 GLY A C   1 
ATOM   1122 O O   . GLY A 1 146 ? -9.60377  20.46556 -35.40178 1.000 12.59617 ? 146 GLY A O   1 
ATOM   1123 N N   . SER A 1 147 ? -10.47615 21.43691 -33.56881 1.000 11.44448 ? 147 SER A N   1 
ATOM   1124 C CA  . SER A 1 147 ? -9.28300  22.22190 -33.27097 1.000 10.91568 ? 147 SER A CA  1 
ATOM   1125 C C   . SER A 1 147 ? -8.14170  21.27782 -32.93270 1.000 14.05883 ? 147 SER A C   1 
ATOM   1126 O O   . SER A 1 147 ? -8.34546  20.23082 -32.32032 1.000 13.25173 ? 147 SER A O   1 
ATOM   1127 C CB  . SER A 1 147 ? -9.52614  23.16251 -32.08670 1.000 13.51010 ? 147 SER A CB  1 
ATOM   1128 O OG  . SER A 1 147 ? -10.58449 24.07579 -32.33476 1.000 12.51717 ? 147 SER A OG  1 
ATOM   1129 N N   . VAL A 1 148 ? -6.92494  21.65506 -33.31258 1.000 12.67708 ? 148 VAL A N   1 
ATOM   1130 C CA  . VAL A 1 148 ? -5.80377  20.72939 -33.18305 1.000 9.85409  ? 148 VAL A CA  1 
ATOM   1131 C C   . VAL A 1 148 ? -4.71449  21.31233 -32.29559 1.000 10.22065 ? 148 VAL A C   1 
ATOM   1132 O O   . VAL A 1 148 ? -4.58367  22.53198 -32.13905 1.000 12.39029 ? 148 VAL A O   1 
ATOM   1133 C CB  . VAL A 1 148 ? -5.21146  20.32396 -34.55177 1.000 15.40047 ? 148 VAL A CB  1 
ATOM   1134 C CG1 . VAL A 1 148 ? -6.29483  19.69393 -35.42234 1.000 13.11266 ? 148 VAL A CG1 1 
ATOM   1135 C CG2 . VAL A 1 148 ? -4.57308  21.52783 -35.24748 1.000 14.95403 ? 148 VAL A CG2 1 
ATOM   1136 N N   . GLY A 1 149 ? -3.94500  20.40778 -31.68934 1.000 12.16419 ? 149 GLY A N   1 
ATOM   1137 C CA  . GLY A 1 149 ? -2.72921  20.75279 -30.97375 1.000 12.94984 ? 149 GLY A CA  1 
ATOM   1138 C C   . GLY A 1 149 ? -1.52507  20.29327 -31.77705 1.000 12.69915 ? 149 GLY A C   1 
ATOM   1139 O O   . GLY A 1 149 ? -1.61136  19.33137 -32.55026 1.000 12.29819 ? 149 GLY A O   1 
ATOM   1140 N N   . PHE A 1 150 ? -0.39890  20.98497 -31.60153 1.000 10.40483 ? 150 PHE A N   1 
ATOM   1141 C CA  . PHE A 1 150 ? 0.73412   20.76263 -32.49117 1.000 9.56584  ? 150 PHE A CA  1 
ATOM   1142 C C   . PHE A 1 150 ? 2.01372   21.28392 -31.85605 1.000 11.01951 ? 150 PHE A C   1 
ATOM   1143 O O   . PHE A 1 150 ? 1.99429   22.14297 -30.96969 1.000 11.88781 ? 150 PHE A O   1 
ATOM   1144 C CB  . PHE A 1 150 ? 0.50894   21.44782 -33.84589 1.000 12.31724 ? 150 PHE A CB  1 
ATOM   1145 C CG  . PHE A 1 150 ? 0.33806   22.94089 -33.74114 1.000 13.91929 ? 150 PHE A CG  1 
ATOM   1146 C CD1 . PHE A 1 150 ? -0.89352  23.49300 -33.42920 1.000 13.71290 ? 150 PHE A CD1 1 
ATOM   1147 C CD2 . PHE A 1 150 ? 1.41421   23.79089 -33.95814 1.000 13.94371 ? 150 PHE A CD2 1 
ATOM   1148 C CE1 . PHE A 1 150 ? -1.04832  24.86566 -33.31466 1.000 18.60514 ? 150 PHE A CE1 1 
ATOM   1149 C CE2 . PHE A 1 150 ? 1.26219   25.16392 -33.86033 1.000 14.90602 ? 150 PHE A CE2 1 
ATOM   1150 C CZ  . PHE A 1 150 ? 0.02693   25.70220 -33.53827 1.000 14.32824 ? 150 PHE A CZ  1 
ATOM   1151 N N   . ASN A 1 151 ? 3.12977   20.74585 -32.33770 1.000 13.22318 ? 151 ASN A N   1 
ATOM   1152 C CA  . ASN A 1 151 ? 4.45382   21.28849 -32.10075 1.000 13.23363 ? 151 ASN A CA  1 
ATOM   1153 C C   . ASN A 1 151 ? 5.07312   21.59750 -33.45512 1.000 11.90823 ? 151 ASN A C   1 
ATOM   1154 O O   . ASN A 1 151 ? 4.66231   21.05248 -34.48252 1.000 14.65547 ? 151 ASN A O   1 
ATOM   1155 C CB  . ASN A 1 151 ? 5.34257   20.30671 -31.32517 1.000 15.05380 ? 151 ASN A CB  1 
ATOM   1156 C CG  . ASN A 1 151 ? 4.97631   20.22635 -29.86906 1.000 22.93031 ? 151 ASN A CG  1 
ATOM   1157 O OD1 . ASN A 1 151 ? 5.52369   20.95115 -29.04177 1.000 25.98644 ? 151 ASN A OD1 1 
ATOM   1158 N ND2 . ASN A 1 151 ? 4.04099   19.35090 -29.54482 1.000 14.85456 ? 151 ASN A ND2 1 
ATOM   1159 N N   . ILE A 1 152 ? 6.05861   22.48580 -33.46678 1.000 15.30584 ? 152 ILE A N   1 
ATOM   1160 C CA  . ILE A 1 152 ? 6.79028   22.79225 -34.68833 1.000 16.23934 ? 152 ILE A CA  1 
ATOM   1161 C C   . ILE A 1 152 ? 8.26890   22.55744 -34.43907 1.000 17.39080 ? 152 ILE A C   1 
ATOM   1162 O O   . ILE A 1 152 ? 8.79740   22.92044 -33.38312 1.000 22.53752 ? 152 ILE A O   1 
ATOM   1163 C CB  . ILE A 1 152 ? 6.54568   24.23264 -35.17264 1.000 17.43193 ? 152 ILE A CB  1 
ATOM   1164 C CG1 . ILE A 1 152 ? 5.05020   24.47300 -35.37298 1.000 15.50063 ? 152 ILE A CG1 1 
ATOM   1165 C CG2 . ILE A 1 152 ? 7.30172   24.48016 -36.47939 1.000 20.84585 ? 152 ILE A CG2 1 
ATOM   1166 C CD1 . ILE A 1 152 ? 4.72080   25.82987 -35.97692 1.000 26.37136 ? 152 ILE A CD1 1 
ATOM   1167 N N   . ASP A 1 153 ? 8.92692   21.93518 -35.41170 1.000 17.64830 ? 153 ASP A N   1 
ATOM   1168 C CA  . ASP A 1 153 ? 10.36703  21.68826 -35.36890 1.000 21.33462 ? 153 ASP A CA  1 
ATOM   1169 C C   . ASP A 1 153 ? 10.91921  22.15506 -36.71023 1.000 22.05489 ? 153 ASP A C   1 
ATOM   1170 O O   . ASP A 1 153 ? 10.73030  21.48142 -37.72648 1.000 19.13069 ? 153 ASP A O   1 
ATOM   1171 C CB  . ASP A 1 153 ? 10.66511  20.21610 -35.11784 1.000 24.30735 ? 153 ASP A CB  1 
ATOM   1172 C CG  . ASP A 1 153 ? 12.14572  19.90357 -35.16736 1.000 43.03427 ? 153 ASP A CG  1 
ATOM   1173 O OD1 . ASP A 1 153 ? 12.96211  20.83443 -34.99669 1.000 38.36361 ? 153 ASP A OD1 1 
ATOM   1174 O OD2 . ASP A 1 153 ? 12.48921  18.72589 -35.39016 1.000 47.99375 ? 153 ASP A OD2 1 
ATOM   1175 N N   . TYR A 1 154 ? 11.58093  23.31249 -36.71197 1.000 26.42950 ? 154 TYR A N   1 
ATOM   1176 C CA  . TYR A 1 154 ? 12.04780  23.94181 -37.94290 1.000 24.49487 ? 154 TYR A CA  1 
ATOM   1177 C C   . TYR A 1 154 ? 10.87810  24.24530 -38.86902 1.000 20.46959 ? 154 TYR A C   1 
ATOM   1178 O O   . TYR A 1 154 ? 10.12883  25.19994 -38.64008 1.000 26.96955 ? 154 TYR A O   1 
ATOM   1179 C CB  . TYR A 1 154 ? 13.07651  23.06437 -38.66155 1.000 24.26712 ? 154 TYR A CB  1 
ATOM   1180 C CG  . TYR A 1 154 ? 13.68318  23.73247 -39.88203 1.000 53.96629 ? 154 TYR A CG  1 
ATOM   1181 C CD1 . TYR A 1 154 ? 13.76241  25.11855 -39.97250 1.000 60.79549 ? 154 TYR A CD1 1 
ATOM   1182 C CD2 . TYR A 1 154 ? 14.15161  22.98015 -40.95249 1.000 43.03193 ? 154 TYR A CD2 1 
ATOM   1183 C CE1 . TYR A 1 154 ? 14.30656  25.73368 -41.08735 1.000 56.66301 ? 154 TYR A CE1 1 
ATOM   1184 C CE2 . TYR A 1 154 ? 14.69686  23.58628 -42.06919 1.000 46.86043 ? 154 TYR A CE2 1 
ATOM   1185 C CZ  . TYR A 1 154 ? 14.77213  24.96129 -42.13106 1.000 56.26158 ? 154 TYR A CZ  1 
ATOM   1186 O OH  . TYR A 1 154 ? 15.31531  25.56598 -43.24177 1.000 85.23959 ? 154 TYR A OH  1 
ATOM   1187 N N   . ASP A 1 155 ? 10.70862  23.44671 -39.92053 1.000 23.70922 ? 155 ASP A N   1 
ATOM   1188 C CA  . ASP A 1 155 ? 9.64489   23.67363 -40.88957 1.000 24.09508 ? 155 ASP A CA  1 
ATOM   1189 C C   . ASP A 1 155 ? 8.52079   22.65447 -40.78711 1.000 16.33240 ? 155 ASP A C   1 
ATOM   1190 O O   . ASP A 1 155 ? 7.56314   22.72557 -41.56820 1.000 26.35602 ? 155 ASP A O   1 
ATOM   1191 C CB  . ASP A 1 155 ? 10.21172  23.66778 -42.31831 1.000 23.25880 ? 155 ASP A CB  1 
ATOM   1192 C CG  . ASP A 1 155 ? 10.85358  22.33626 -42.69264 1.000 32.42864 ? 155 ASP A CG  1 
ATOM   1193 O OD1 . ASP A 1 155 ? 11.30514  21.59834 -41.78784 1.000 30.74583 ? 155 ASP A OD1 1 
ATOM   1194 O OD2 . ASP A 1 155 ? 10.91529  22.02819 -43.90131 1.000 30.56367 ? 155 ASP A OD2 1 
ATOM   1195 N N   . CYS A 1 156 ? 8.60429   21.71319 -39.85041 1.000 18.33579 ? 156 CYS A N   1 
ATOM   1196 C CA  . CYS A 1 156 ? 7.72250   20.55584 -39.82557 1.000 16.06823 ? 156 CYS A CA  1 
ATOM   1197 C C   . CYS A 1 156 ? 6.74571   20.69028 -38.66474 1.000 16.59607 ? 156 CYS A C   1 
ATOM   1198 O O   . CYS A 1 156 ? 7.16551   20.84758 -37.51045 1.000 17.11060 ? 156 CYS A O   1 
ATOM   1199 C CB  . CYS A 1 156 ? 8.53171   19.26700 -39.71329 1.000 16.92553 ? 156 CYS A CB  1 
ATOM   1200 S SG  . CYS A 1 156 ? 7.51631   17.79725 -39.61693 1.000 19.58465 ? 156 CYS A SG  1 
ATOM   1201 N N   . VAL A 1 157 ? 5.45323   20.61585 -38.97288 1.000 15.57977 ? 157 VAL A N   1 
ATOM   1202 C CA  . VAL A 1 157 ? 4.39455   20.64838 -37.96638 1.000 16.36733 ? 157 VAL A CA  1 
ATOM   1203 C C   . VAL A 1 157 ? 4.08818   19.21618 -37.55440 1.000 16.30612 ? 157 VAL A C   1 
ATOM   1204 O O   . VAL A 1 157 ? 3.69669   18.39731 -38.39182 1.000 14.00119 ? 157 VAL A O   1 
ATOM   1205 C CB  . VAL A 1 157 ? 3.12929   21.33919 -38.50156 1.000 11.70193 ? 157 VAL A CB  1 
ATOM   1206 C CG1 . VAL A 1 157 ? 2.02450   21.32925 -37.43591 1.000 16.85197 ? 157 VAL A CG1 1 
ATOM   1207 C CG2 . VAL A 1 157 ? 3.43463   22.76781 -38.96901 1.000 16.58283 ? 157 VAL A CG2 1 
ATOM   1208 N N   . SER A 1 158 ? 4.27755   18.90700 -36.27168 1.000 13.44758 ? 158 SER A N   1 
ATOM   1209 C CA  . SER A 1 158 ? 3.86727   17.62338 -35.69945 1.000 11.41838 ? 158 SER A CA  1 
ATOM   1210 C C   . SER A 1 158 ? 2.50562   17.80797 -35.03726 1.000 13.55202 ? 158 SER A C   1 
ATOM   1211 O O   . SER A 1 158 ? 2.40726   18.39330 -33.95545 1.000 14.34925 ? 158 SER A O   1 
ATOM   1212 C CB  . SER A 1 158 ? 4.89476   17.11708 -34.69403 1.000 19.61562 ? 158 SER A CB  1 
ATOM   1213 O OG  . SER A 1 158 ? 6.04147   16.62663 -35.35134 1.000 20.74957 ? 158 SER A OG  1 
ATOM   1214 N N   . PHE A 1 159 ? 1.45574   17.31926 -35.68886 1.000 12.70056 ? 159 PHE A N   1 
ATOM   1215 C CA  . PHE A 1 159 ? 0.12285   17.33962 -35.09379 1.000 14.17922 ? 159 PHE A CA  1 
ATOM   1216 C C   . PHE A 1 159 ? -0.00680  16.19770 -34.09429 1.000 14.10134 ? 159 PHE A C   1 
ATOM   1217 O O   . PHE A 1 159 ? 0.26981   15.04036 -34.42428 1.000 14.78905 ? 159 PHE A O   1 
ATOM   1218 C CB  . PHE A 1 159 ? -0.95603  17.21009 -36.17184 1.000 13.38912 ? 159 PHE A CB  1 
ATOM   1219 C CG  . PHE A 1 159 ? -0.97417  18.33632 -37.16774 1.000 12.03769 ? 159 PHE A CG  1 
ATOM   1220 C CD1 . PHE A 1 159 ? -1.57084  19.54694 -36.85353 1.000 10.70360 ? 159 PHE A CD1 1 
ATOM   1221 C CD2 . PHE A 1 159 ? -0.41758  18.17414 -38.43386 1.000 12.12540 ? 159 PHE A CD2 1 
ATOM   1222 C CE1 . PHE A 1 159 ? -1.58936  20.59505 -37.79052 1.000 11.80714 ? 159 PHE A CE1 1 
ATOM   1223 C CE2 . PHE A 1 159 ? -0.44106  19.19483 -39.36559 1.000 11.95283 ? 159 PHE A CE2 1 
ATOM   1224 C CZ  . PHE A 1 159 ? -1.02321  20.40586 -39.05187 1.000 10.76470 ? 159 PHE A CZ  1 
ATOM   1225 N N   . CYS A 1 160 ? -0.45956  16.51873 -32.87897 1.000 13.67643 ? 160 CYS A N   1 
ATOM   1226 C CA  . CYS A 1 160 ? -0.55095  15.53722 -31.80573 1.000 15.50350 ? 160 CYS A CA  1 
ATOM   1227 C C   . CYS A 1 160 ? -1.92225  15.45089 -31.14762 1.000 12.37238 ? 160 CYS A C   1 
ATOM   1228 O O   . CYS A 1 160 ? -2.15242  14.50433 -30.38373 1.000 15.83465 ? 160 CYS A O   1 
ATOM   1229 C CB  . CYS A 1 160 ? 0.49939   15.82631 -30.71586 1.000 13.53279 ? 160 CYS A CB  1 
ATOM   1230 S SG  . CYS A 1 160 ? 0.36810   17.46424 -29.93308 1.000 15.92255 ? 160 CYS A SG  1 
ATOM   1231 N N   . TYR A 1 161 ? -2.84073  16.38021 -31.42162 1.000 11.57359 ? 161 TYR A N   1 
ATOM   1232 C CA  . TYR A 1 161 ? -4.10894  16.41180 -30.69918 1.000 12.33376 ? 161 TYR A CA  1 
ATOM   1233 C C   . TYR A 1 161 ? -5.21372  16.93663 -31.59725 1.000 13.58290 ? 161 TYR A C   1 
ATOM   1234 O O   . TYR A 1 161 ? -5.00714  17.88655 -32.35430 1.000 12.87668 ? 161 TYR A O   1 
ATOM   1235 C CB  . TYR A 1 161 ? -4.00309  17.29321 -29.44171 1.000 12.73602 ? 161 TYR A CB  1 
ATOM   1236 C CG  . TYR A 1 161 ? -5.27210  17.41497 -28.61254 1.000 12.18042 ? 161 TYR A CG  1 
ATOM   1237 C CD1 . TYR A 1 161 ? -5.57630  16.48371 -27.62611 1.000 10.23172 ? 161 TYR A CD1 1 
ATOM   1238 C CD2 . TYR A 1 161 ? -6.14090  18.48436 -28.78380 1.000 10.06572 ? 161 TYR A CD2 1 
ATOM   1239 C CE1 . TYR A 1 161 ? -6.72445  16.60648 -26.85277 1.000 11.94598 ? 161 TYR A CE1 1 
ATOM   1240 C CE2 . TYR A 1 161 ? -7.29618  18.61789 -28.00768 1.000 12.18726 ? 161 TYR A CE2 1 
ATOM   1241 C CZ  . TYR A 1 161 ? -7.58412  17.67086 -27.04972 1.000 12.09033 ? 161 TYR A CZ  1 
ATOM   1242 O OH  . TYR A 1 161 ? -8.71716  17.78722 -26.27867 1.000 13.47869 ? 161 TYR A OH  1 
ATOM   1243 N N   . MET A 1 162 ? -6.39279  16.32031 -31.49081 1.000 11.54888 ? 162 MET A N   1 
ATOM   1244 C CA  . MET A 1 162 ? -7.61494  16.86170 -32.06829 1.000 9.29002  ? 162 MET A CA  1 
ATOM   1245 C C   . MET A 1 162 ? -8.67954  16.85883 -30.98376 1.000 13.00503 ? 162 MET A C   1 
ATOM   1246 O O   . MET A 1 162 ? -8.82825  15.86863 -30.26441 1.000 11.56791 ? 162 MET A O   1 
ATOM   1247 C CB  . MET A 1 162 ? -8.08551  16.06503 -33.28833 1.000 13.47422 ? 162 MET A CB  1 
ATOM   1248 C CG  . MET A 1 162 ? -9.39491  16.61086 -33.85739 1.000 12.83925 ? 162 MET A CG  1 
ATOM   1249 S SD  . MET A 1 162 ? -9.78189  16.03195 -35.51754 1.000 17.86357 ? 162 MET A SD  1 
ATOM   1250 C CE  . MET A 1 162 ? -8.67891  17.04220 -36.51760 1.000 19.75876 ? 162 MET A CE  1 
ATOM   1251 N N   . HIS A 1 163 ? -9.40459  17.96324 -30.84991 1.000 11.37562 ? 163 HIS A N   1 
ATOM   1252 C CA  . HIS A 1 163 ? -10.28880 18.13105 -29.70419 1.000 11.60213 ? 163 HIS A CA  1 
ATOM   1253 C C   . HIS A 1 163 ? -11.65611 17.47141 -29.92043 1.000 10.90560 ? 163 HIS A C   1 
ATOM   1254 O O   . HIS A 1 163 ? -12.28953 17.67165 -30.96067 1.000 12.39573 ? 163 HIS A O   1 
ATOM   1255 C CB  . HIS A 1 163 ? -10.49430 19.61342 -29.41343 1.000 13.46360 ? 163 HIS A CB  1 
ATOM   1256 C CG  . HIS A 1 163 ? -11.34064 19.84746 -28.21607 1.000 9.71997  ? 163 HIS A CG  1 
ATOM   1257 N ND1 . HIS A 1 163 ? -11.01150 19.33859 -26.97819 1.000 11.26283 ? 163 HIS A ND1 1 
ATOM   1258 C CD2 . HIS A 1 163 ? -12.53268 20.47305 -28.06630 1.000 11.20389 ? 163 HIS A CD2 1 
ATOM   1259 C CE1 . HIS A 1 163 ? -11.95178 19.66609 -26.10984 1.000 10.16263 ? 163 HIS A CE1 1 
ATOM   1260 N NE2 . HIS A 1 163 ? -12.88576 20.35202 -26.74468 1.000 10.71711 ? 163 HIS A NE2 1 
ATOM   1261 N N   . HIS A 1 164 ? -12.13556 16.73208 -28.91444 1.000 13.34962 ? 164 HIS A N   1 
ATOM   1262 C CA  . HIS A 1 164 ? -13.43406 16.06148 -28.99646 1.000 9.48857  ? 164 HIS A CA  1 
ATOM   1263 C C   . HIS A 1 164 ? -14.40876 16.41623 -27.88057 1.000 12.50807 ? 164 HIS A C   1 
ATOM   1264 O O   . HIS A 1 164 ? -15.60897 16.44027 -28.13660 1.000 15.60300 ? 164 HIS A O   1 
ATOM   1265 C CB  . HIS A 1 164 ? -13.27566 14.53184 -28.99763 1.000 11.64931 ? 164 HIS A CB  1 
ATOM   1266 C CG  . HIS A 1 164 ? -12.64190 13.98125 -30.23788 1.000 14.61506 ? 164 HIS A CG  1 
ATOM   1267 N ND1 . HIS A 1 164 ? -13.33656 13.23815 -31.16986 1.000 14.97610 ? 164 HIS A ND1 1 
ATOM   1268 C CD2 . HIS A 1 164 ? -11.37197 14.06717 -30.69641 1.000 13.43181 ? 164 HIS A CD2 1 
ATOM   1269 C CE1 . HIS A 1 164 ? -12.51882 12.88918 -32.14701 1.000 13.14269 ? 164 HIS A CE1 1 
ATOM   1270 N NE2 . HIS A 1 164 ? -11.31907 13.37363 -31.87965 1.000 12.98361 ? 164 HIS A NE2 1 
ATOM   1271 N N   . MET A 1 165 ? -13.96532 16.64725 -26.64088 1.000 12.21219 ? 165 MET A N   1 
ATOM   1272 C CA  . MET A 1 165 ? -14.96813 16.70732 -25.57665 1.000 14.46949 ? 165 MET A CA  1 
ATOM   1273 C C   . MET A 1 165 ? -14.43679 17.41691 -24.33704 1.000 10.71632 ? 165 MET A C   1 
ATOM   1274 O O   . MET A 1 165 ? -13.22920 17.58395 -24.15473 1.000 12.73192 ? 165 MET A O   1 
ATOM   1275 C CB  . MET A 1 165 ? -15.44773 15.29862 -25.21246 1.000 14.68166 ? 165 MET A CB  1 
ATOM   1276 C CG  . MET A 1 165 ? -14.37658 14.42150 -24.60265 1.000 17.96222 ? 165 MET A CG  1 
ATOM   1277 S SD  . MET A 1 165 ? -14.85266 12.68064 -24.71638 1.000 25.56100 ? 165 MET A SD  1 
ATOM   1278 C CE  . MET A 1 165 ? -14.24492 12.06268 -23.15685 1.000 28.11362 ? 165 MET A CE  1 
ATOM   1279 N N   . GLU A 1 166 ? -15.37967 17.81637 -23.47626 1.000 12.59504 ? 166 GLU A N   1 
ATOM   1280 C CA  . GLU A 1 166 ? -15.09237 18.46673 -22.20497 1.000 16.92871 ? 166 GLU A CA  1 
ATOM   1281 C C   . GLU A 1 166 ? -15.59841 17.59480 -21.06585 1.000 11.96760 ? 166 GLU A C   1 
ATOM   1282 O O   . GLU A 1 166 ? -16.75266 17.15425 -21.08307 1.000 13.23117 ? 166 GLU A O   1 
ATOM   1283 C CB  . GLU A 1 166 ? -15.74128 19.84766 -22.12119 1.000 15.82144 ? 166 GLU A CB  1 
ATOM   1284 C CG  . GLU A 1 166 ? -15.43547 20.57514 -20.81033 1.000 15.36985 ? 166 GLU A CG  1 
ATOM   1285 C CD  . GLU A 1 166 ? -15.91975 22.00674 -20.81953 1.000 18.64880 ? 166 GLU A CD  1 
ATOM   1286 O OE1 . GLU A 1 166 ? -15.46048 22.77730 -21.68333 1.000 15.05290 ? 166 GLU A OE1 1 
ATOM   1287 O OE2 . GLU A 1 166 ? -16.76021 22.35649 -19.96544 1.000 18.78428 ? 166 GLU A OE2 1 
ATOM   1288 N N   . LEU A 1 167 ? -14.73368 17.34954 -20.09303 1.000 15.35878 ? 167 LEU A N   1 
ATOM   1289 C CA  . LEU A 1 167 ? -15.00579 16.53841 -18.91745 1.000 15.02775 ? 167 LEU A CA  1 
ATOM   1290 C C   . LEU A 1 167 ? -15.34723 17.42352 -17.73061 1.000 17.43460 ? 167 LEU A C   1 
ATOM   1291 O O   . LEU A 1 167 ? -15.10699 18.63558 -17.74416 1.000 17.72806 ? 167 LEU A O   1 
ATOM   1292 C CB  . LEU A 1 167 ? -13.78597 15.67367 -18.59177 1.000 15.89763 ? 167 LEU A CB  1 
ATOM   1293 C CG  . LEU A 1 167 ? -13.48093 14.55083 -19.58402 1.000 16.77483 ? 167 LEU A CG  1 
ATOM   1294 C CD1 . LEU A 1 167 ? -12.02165 14.08939 -19.45691 1.000 15.65283 ? 167 LEU A CD1 1 
ATOM   1295 C CD2 . LEU A 1 167 ? -14.43710 13.39247 -19.32027 1.000 16.06783 ? 167 LEU A CD2 1 
ATOM   1296 N N   . PRO A 1 168 ? -15.90310 16.84255 -16.66789 1.000 21.72239 ? 168 PRO A N   1 
ATOM   1297 C CA  . PRO A 1 168 ? -16.21496 17.63506 -15.47357 1.000 20.83242 ? 168 PRO A CA  1 
ATOM   1298 C C   . PRO A 1 168 ? -14.98669 18.34789 -14.92145 1.000 24.66504 ? 168 PRO A C   1 
ATOM   1299 O O   . PRO A 1 168 ? -13.86383 17.83652 -14.96582 1.000 24.14791 ? 168 PRO A O   1 
ATOM   1300 C CB  . PRO A 1 168 ? -16.74984 16.58895 -14.48897 1.000 23.26985 ? 168 PRO A CB  1 
ATOM   1301 C CG  . PRO A 1 168 ? -17.32473 15.51925 -15.37554 1.000 22.45458 ? 168 PRO A CG  1 
ATOM   1302 C CD  . PRO A 1 168 ? -16.37686 15.45122 -16.55216 1.000 17.57933 ? 168 PRO A CD  1 
ATOM   1303 N N   . THR A 1 169 ? -15.22632 19.54929 -14.39135 1.000 23.48649 ? 169 THR A N   1 
ATOM   1304 C CA  . THR A 1 169 ? -14.20579 20.44810 -13.85452 1.000 22.23834 ? 169 THR A CA  1 
ATOM   1305 C C   . THR A 1 169 ? -13.59296 21.30669 -14.95839 1.000 23.84567 ? 169 THR A C   1 
ATOM   1306 O O   . THR A 1 169 ? -12.63879 22.05110 -14.71341 1.000 24.46392 ? 169 THR A O   1 
ATOM   1307 C CB  . THR A 1 169 ? -13.09769 19.68803 -13.10989 1.000 28.19566 ? 169 THR A CB  1 
ATOM   1308 O OG1 . THR A 1 169 ? -12.25545 18.99897 -14.04200 1.000 31.05437 ? 169 THR A OG1 1 
ATOM   1309 C CG2 . THR A 1 169 ? -13.68266 18.69139 -12.11192 1.000 34.62080 ? 169 THR A CG2 1 
ATOM   1310 N N   . GLY A 1 170 ? -14.12776 21.22191 -16.17095 1.000 19.98227 ? 170 GLY A N   1 
ATOM   1311 C CA  . GLY A 1 170 ? -13.63828 22.08571 -17.23132 1.000 16.85498 ? 170 GLY A CA  1 
ATOM   1312 C C   . GLY A 1 170 ? -12.29561 21.69123 -17.80407 1.000 17.04118 ? 170 GLY A C   1 
ATOM   1313 O O   . GLY A 1 170 ? -11.45925 22.56698 -18.07579 1.000 21.37372 ? 170 GLY A O   1 
ATOM   1314 N N   . VAL A 1 171 ? -12.05551 20.39322 -17.97819 1.000 16.93144 ? 171 VAL A N   1 
ATOM   1315 C CA  . VAL A 1 171 ? -10.83831 19.90655 -18.61091 1.000 13.99207 ? 171 VAL A CA  1 
ATOM   1316 C C   . VAL A 1 171 ? -11.24724 19.14192 -19.86039 1.000 15.38434 ? 171 VAL A C   1 
ATOM   1317 O O   . VAL A 1 171 ? -12.41932 18.80738 -20.05953 1.000 18.26352 ? 171 VAL A O   1 
ATOM   1318 C CB  . VAL A 1 171 ? -9.97743  19.03387 -17.67110 1.000 18.51185 ? 171 VAL A CB  1 
ATOM   1319 C CG1 . VAL A 1 171 ? -9.51627  19.86120 -16.47511 1.000 17.66717 ? 171 VAL A CG1 1 
ATOM   1320 C CG2 . VAL A 1 171 ? -10.75257 17.81916 -17.21205 1.000 17.49491 ? 171 VAL A CG2 1 
ATOM   1321 N N   . HIS A 1 172 ? -10.27113 18.89518 -20.72898 1.000 13.34039 ? 172 HIS A N   1 
ATOM   1322 C CA  . HIS A 1 172 ? -10.59294 18.54591 -22.10180 1.000 11.62024 ? 172 HIS A CA  1 
ATOM   1323 C C   . HIS A 1 172 ? -9.89838  17.26892 -22.55448 1.000 12.97646 ? 172 HIS A C   1 
ATOM   1324 O O   . HIS A 1 172 ? -8.81729  16.90529 -22.07943 1.000 14.39571 ? 172 HIS A O   1 
ATOM   1325 C CB  . HIS A 1 172 ? -10.26222 19.73122 -23.00960 1.000 12.12331 ? 172 HIS A CB  1 
ATOM   1326 C CG  . HIS A 1 172 ? -11.00847 20.96370 -22.62247 1.000 12.94337 ? 172 HIS A CG  1 
ATOM   1327 N ND1 . HIS A 1 172 ? -10.45313 21.96328 -21.85441 1.000 12.27802 ? 172 HIS A ND1 1 
ATOM   1328 C CD2 . HIS A 1 172 ? -12.30018 21.31675 -22.82602 1.000 14.83888 ? 172 HIS A CD2 1 
ATOM   1329 C CE1 . HIS A 1 172 ? -11.36096 22.89857 -21.63344 1.000 13.46177 ? 172 HIS A CE1 1 
ATOM   1330 N NE2 . HIS A 1 172 ? -12.49052 22.52976 -22.21132 1.000 15.35518 ? 172 HIS A NE2 1 
ATOM   1331 N N   . ALA A 1 173 ? -10.55712 16.58062 -23.48082 1.000 11.76930 ? 173 ALA A N   1 
ATOM   1332 C CA  . ALA A 1 173 ? -10.10920 15.27521 -23.93397 1.000 14.67133 ? 173 ALA A CA  1 
ATOM   1333 C C   . ALA A 1 173 ? -10.25750 15.16459 -25.44406 1.000 12.87786 ? 173 ALA A C   1 
ATOM   1334 O O   . ALA A 1 173 ? -11.15025 15.76817 -26.05288 1.000 12.87834 ? 173 ALA A O   1 
ATOM   1335 C CB  . ALA A 1 173 ? -10.88979 14.15497 -23.22756 1.000 14.08755 ? 173 ALA A CB  1 
ATOM   1336 N N   . GLY A 1 174 ? -9.36667  14.38878 -26.04387 1.000 13.02641 ? 174 GLY A N   1 
ATOM   1337 C CA  . GLY A 1 174 ? -9.34265  14.27116 -27.48973 1.000 14.82156 ? 174 GLY A CA  1 
ATOM   1338 C C   . GLY A 1 174 ? -8.43144  13.14682 -27.92420 1.000 11.52941 ? 174 GLY A C   1 
ATOM   1339 O O   . GLY A 1 174 ? -8.02268  12.30608 -27.11975 1.000 13.60807 ? 174 GLY A O   1 
ATOM   1340 N N   . THR A 1 175 ? -8.11493  13.14583 -29.21423 1.000 14.09377 ? 175 THR A N   1 
ATOM   1341 C CA  . THR A 1 175 ? -7.43005  12.03764 -29.85879 1.000 11.48760 ? 175 THR A CA  1 
ATOM   1342 C C   . THR A 1 175 ? -6.13000  12.50834 -30.49898 1.000 13.39872 ? 175 THR A C   1 
ATOM   1343 O O   . THR A 1 175 ? -5.87173  13.70707 -30.64225 1.000 12.27820 ? 175 THR A O   1 
ATOM   1344 C CB  . THR A 1 175 ? -8.32983  11.39651 -30.92804 1.000 11.08958 ? 175 THR A CB  1 
ATOM   1345 O OG1 . THR A 1 175 ? -8.55426  12.33775 -31.99255 1.000 12.58804 ? 175 THR A OG1 1 
ATOM   1346 C CG2 . THR A 1 175 ? -9.67665  10.97866 -30.32374 1.000 11.12980 ? 175 THR A CG2 1 
ATOM   1347 N N   . ASP A 1 176 ? -5.29180  11.54496 -30.87231 1.000 13.00504 ? 176 ASP A N   1 
ATOM   1348 C CA  . ASP A 1 176 ? -4.24411  11.85709 -31.82813 1.000 12.26269 ? 176 ASP A CA  1 
ATOM   1349 C C   . ASP A 1 176 ? -4.87168  11.95648 -33.21933 1.000 15.62316 ? 176 ASP A C   1 
ATOM   1350 O O   . ASP A 1 176 ? -6.08669  11.81416 -33.38617 1.000 14.24313 ? 176 ASP A O   1 
ATOM   1351 C CB  . ASP A 1 176 ? -3.11529  10.82509 -31.74122 1.000 15.26414 ? 176 ASP A CB  1 
ATOM   1352 C CG  . ASP A 1 176 ? -3.57276  9.40068  -32.05944 1.000 15.50803 ? 176 ASP A CG  1 
ATOM   1353 O OD1 . ASP A 1 176 ? -4.55585  9.22281  -32.80849 1.000 17.28835 ? 176 ASP A OD1 1 
ATOM   1354 O OD2 . ASP A 1 176 ? -2.92330  8.45373  -31.56256 1.000 19.07325 ? 176 ASP A OD2 1 
ATOM   1355 N N   . LEU A 1 177 ? -4.05429  12.22461 -34.23934 1.000 13.28346 ? 177 LEU A N   1 
ATOM   1356 C CA  . LEU A 1 177 ? -4.64118  12.42343 -35.55929 1.000 13.75392 ? 177 LEU A CA  1 
ATOM   1357 C C   . LEU A 1 177 ? -4.95649  11.10833 -36.26459 1.000 15.54518 ? 177 LEU A C   1 
ATOM   1358 O O   . LEU A 1 177 ? -5.50724  11.12977 -37.37154 1.000 19.59666 ? 177 LEU A O   1 
ATOM   1359 C CB  . LEU A 1 177 ? -3.72860  13.30837 -36.41886 1.000 12.82567 ? 177 LEU A CB  1 
ATOM   1360 C CG  . LEU A 1 177 ? -4.00675  14.81817 -36.30335 1.000 15.77054 ? 177 LEU A CG  1 
ATOM   1361 C CD1 . LEU A 1 177 ? -5.28756  15.18621 -37.02175 1.000 17.81679 ? 177 LEU A CD1 1 
ATOM   1362 C CD2 . LEU A 1 177 ? -4.06127  15.27038 -34.83449 1.000 16.01387 ? 177 LEU A CD2 1 
ATOM   1363 N N   . GLU A 1 178 ? -4.64009  9.96885  -35.64968 1.000 15.97673 ? 178 GLU A N   1 
ATOM   1364 C CA  . GLU A 1 178 ? -5.17488  8.69007  -36.08695 1.000 16.41266 ? 178 GLU A CA  1 
ATOM   1365 C C   . GLU A 1 178 ? -6.48943  8.35277  -35.38989 1.000 16.98040 ? 178 GLU A C   1 
ATOM   1366 O O   . GLU A 1 178 ? -7.00753  7.24336  -35.56299 1.000 17.94356 ? 178 GLU A O   1 
ATOM   1367 C CB  . GLU A 1 178 ? -4.14846  7.57928  -35.86006 1.000 17.30205 ? 178 GLU A CB  1 
ATOM   1368 C CG  . GLU A 1 178 ? -2.96909  7.63369  -36.82799 1.000 25.62161 ? 178 GLU A CG  1 
ATOM   1369 C CD  . GLU A 1 178 ? -1.94952  6.53764  -36.58082 1.000 31.03756 ? 178 GLU A CD  1 
ATOM   1370 O OE1 . GLU A 1 178 ? -1.81214  6.09751  -35.41997 1.000 33.25525 ? 178 GLU A OE1 1 
ATOM   1371 O OE2 . GLU A 1 178 ? -1.28961  6.11511  -37.55057 1.000 40.16418 ? 178 GLU A OE2 1 
ATOM   1372 N N   . GLY A 1 179 ? -7.03491  9.28181  -34.60169 1.000 11.90361 ? 179 GLY A N   1 
ATOM   1373 C CA  . GLY A 1 179 ? -8.33258  9.09966  -33.98046 1.000 13.26387 ? 179 GLY A CA  1 
ATOM   1374 C C   . GLY A 1 179 ? -8.34721  8.27362  -32.71361 1.000 14.91658 ? 179 GLY A C   1 
ATOM   1375 O O   . GLY A 1 179 ? -9.43285  7.90172  -32.25761 1.000 18.04431 ? 179 GLY A O   1 
ATOM   1376 N N   . ASN A 1 180 ? -7.18655  7.97961  -32.12662 1.000 15.53557 ? 180 ASN A N   1 
ATOM   1377 C CA  . ASN A 1 180 ? -7.11371  7.20549  -30.89239 1.000 13.95646 ? 180 ASN A CA  1 
ATOM   1378 C C   . ASN A 1 180 ? -7.10442  8.15201  -29.69966 1.000 14.17534 ? 180 ASN A C   1 
ATOM   1379 O O   . ASN A 1 180 ? -6.27666  9.06417  -29.63294 1.000 14.09835 ? 180 ASN A O   1 
ATOM   1380 C CB  . ASN A 1 180 ? -5.86674  6.32064  -30.87457 1.000 17.44538 ? 180 ASN A CB  1 
ATOM   1381 C CG  . ASN A 1 180 ? -5.98620  5.13950  -31.81632 1.000 19.87278 ? 180 ASN A CG  1 
ATOM   1382 O OD1 . ASN A 1 180 ? -7.03382  4.50355  -31.89014 1.000 21.98491 ? 180 ASN A OD1 1 
ATOM   1383 N ND2 . ASN A 1 180 ? -4.92365  4.85941  -32.55876 1.000 22.50294 ? 180 ASN A ND2 1 
ATOM   1384 N N   . PHE A 1 181 ? -8.02645  7.93781  -28.76613 1.000 13.83082 ? 181 PHE A N   1 
ATOM   1385 C CA  . PHE A 1 181 ? -8.11322  8.82777  -27.61958 1.000 12.61470 ? 181 PHE A CA  1 
ATOM   1386 C C   . PHE A 1 181 ? -6.85350  8.75841  -26.77180 1.000 17.10099 ? 181 PHE A C   1 
ATOM   1387 O O   . PHE A 1 181 ? -6.23920  7.70040  -26.61507 1.000 17.94366 ? 181 PHE A O   1 
ATOM   1388 C CB  . PHE A 1 181 ? -9.32861  8.48412  -26.75777 1.000 14.13128 ? 181 PHE A CB  1 
ATOM   1389 C CG  . PHE A 1 181 ? -10.51856 9.36014  -27.02471 1.000 15.73970 ? 181 PHE A CG  1 
ATOM   1390 C CD1 . PHE A 1 181 ? -10.65617 10.58196 -26.37222 1.000 17.88493 ? 181 PHE A CD1 1 
ATOM   1391 C CD2 . PHE A 1 181 ? -11.48741 8.98032  -27.93691 1.000 13.95207 ? 181 PHE A CD2 1 
ATOM   1392 C CE1 . PHE A 1 181 ? -11.74704 11.40393 -26.62859 1.000 12.75337 ? 181 PHE A CE1 1 
ATOM   1393 C CE2 . PHE A 1 181 ? -12.58167 9.79636  -28.18598 1.000 14.22533 ? 181 PHE A CE2 1 
ATOM   1394 C CZ  . PHE A 1 181 ? -12.70631 11.01037 -27.52862 1.000 14.10947 ? 181 PHE A CZ  1 
ATOM   1395 N N   . TYR A 1 182 ? -6.46304  9.90942  -26.24387 1.000 14.30996 ? 182 TYR A N   1 
ATOM   1396 C CA  . TYR A 1 182 ? -5.60530  9.95986  -25.07258 1.000 14.20168 ? 182 TYR A CA  1 
ATOM   1397 C C   . TYR A 1 182 ? -6.45230  9.65596  -23.84364 1.000 16.54766 ? 182 TYR A C   1 
ATOM   1398 O O   . TYR A 1 182 ? -7.48983  10.28992 -23.62887 1.000 16.82239 ? 182 TYR A O   1 
ATOM   1399 C CB  . TYR A 1 182 ? -4.95427  11.34350 -24.94432 1.000 13.75586 ? 182 TYR A CB  1 
ATOM   1400 C CG  . TYR A 1 182 ? -3.93864  11.65651 -26.03335 1.000 11.05030 ? 182 TYR A CG  1 
ATOM   1401 C CD1 . TYR A 1 182 ? -2.64916  11.13918 -25.97500 1.000 14.26216 ? 182 TYR A CD1 1 
ATOM   1402 C CD2 . TYR A 1 182 ? -4.27743  12.45654 -27.11950 1.000 10.72740 ? 182 TYR A CD2 1 
ATOM   1403 C CE1 . TYR A 1 182 ? -1.72100  11.41455 -26.96700 1.000 13.56379 ? 182 TYR A CE1 1 
ATOM   1404 C CE2 . TYR A 1 182 ? -3.35812  12.73674 -28.11012 1.000 10.97151 ? 182 TYR A CE2 1 
ATOM   1405 C CZ  . TYR A 1 182 ? -2.08231  12.21740 -28.02862 1.000 12.90651 ? 182 TYR A CZ  1 
ATOM   1406 O OH  . TYR A 1 182 ? -1.16856  12.49582 -29.02582 1.000 14.25351 ? 182 TYR A OH  1 
ATOM   1407 N N   . GLY A 1 183 ? -6.02626  8.67617  -23.04732 1.000 15.06152 ? 183 GLY A N   1 
ATOM   1408 C CA  . GLY A 1 183 ? -6.76844  8.28915  -21.87033 1.000 17.78155 ? 183 GLY A CA  1 
ATOM   1409 C C   . GLY A 1 183 ? -7.92776  7.35131  -22.15590 1.000 17.59315 ? 183 GLY A C   1 
ATOM   1410 O O   . GLY A 1 183 ? -8.16082  6.93211  -23.29450 1.000 21.16749 ? 183 GLY A O   1 
ATOM   1411 N N   . PRO A 1 184 ? -8.69418  7.01999  -21.10859 1.000 15.57523 ? 184 PRO A N   1 
ATOM   1412 C CA  . PRO A 1 184 ? -9.71805  5.96689  -21.22474 1.000 14.61871 ? 184 PRO A CA  1 
ATOM   1413 C C   . PRO A 1 184 ? -11.07555 6.46590  -21.69408 1.000 29.79350 ? 184 PRO A C   1 
ATOM   1414 O O   . PRO A 1 184 ? -12.09946 5.82427  -21.44568 1.000 38.68367 ? 184 PRO A O   1 
ATOM   1415 C CB  . PRO A 1 184 ? -9.79933  5.42346  -19.79495 1.000 19.66713 ? 184 PRO A CB  1 
ATOM   1416 C CG  . PRO A 1 184 ? -9.50540  6.62943  -18.94364 1.000 25.56483 ? 184 PRO A CG  1 
ATOM   1417 C CD  . PRO A 1 184 ? -8.52738  7.48885  -19.72372 1.000 18.10821 ? 184 PRO A CD  1 
ATOM   1418 N N   . PHE A 1 185 ? -11.09835 7.58985  -22.38743 1.000 16.53934 ? 185 PHE A N   1 
ATOM   1419 C CA  . PHE A 1 185 ? -12.34804 8.24777  -22.72322 1.000 13.61909 ? 185 PHE A CA  1 
ATOM   1420 C C   . PHE A 1 185 ? -12.87967 7.74847  -24.06268 1.000 17.76655 ? 185 PHE A C   1 
ATOM   1421 O O   . PHE A 1 185 ? -12.14071 7.20201  -24.88530 1.000 19.40894 ? 185 PHE A O   1 
ATOM   1422 C CB  . PHE A 1 185 ? -12.13630 9.76170  -22.73291 1.000 17.27793 ? 185 PHE A CB  1 
ATOM   1423 C CG  . PHE A 1 185 ? -11.40758 10.25655 -21.51226 1.000 14.45241 ? 185 PHE A CG  1 
ATOM   1424 C CD1 . PHE A 1 185 ? -12.01124 10.18733 -20.26649 1.000 15.38168 ? 185 PHE A CD1 1 
ATOM   1425 C CD2 . PHE A 1 185 ? -10.10785 10.74110 -21.60174 1.000 16.90274 ? 185 PHE A CD2 1 
ATOM   1426 C CE1 . PHE A 1 185 ? -11.34541 10.61367 -19.12408 1.000 13.54541 ? 185 PHE A CE1 1 
ATOM   1427 C CE2 . PHE A 1 185 ? -9.43219  11.17611 -20.47275 1.000 17.75157 ? 185 PHE A CE2 1 
ATOM   1428 C CZ  . PHE A 1 185 ? -10.05219 11.11562 -19.22785 1.000 17.44112 ? 185 PHE A CZ  1 
ATOM   1429 N N   . VAL A 1 186 ? -14.19246 7.91212  -24.25387 1.000 15.49667 ? 186 VAL A N   1 
ATOM   1430 C CA  . VAL A 1 186 ? -14.87407 7.53832  -25.48732 1.000 16.33965 ? 186 VAL A CA  1 
ATOM   1431 C C   . VAL A 1 186 ? -15.68855 8.73366  -25.95874 1.000 15.04682 ? 186 VAL A C   1 
ATOM   1432 O O   . VAL A 1 186 ? -16.15047 9.54617  -25.15115 1.000 15.39773 ? 186 VAL A O   1 
ATOM   1433 C CB  . VAL A 1 186 ? -15.78044 6.29813  -25.29358 1.000 16.81051 ? 186 VAL A CB  1 
ATOM   1434 C CG1 . VAL A 1 186 ? -14.94795 5.08675  -24.89333 1.000 20.83812 ? 186 VAL A CG1 1 
ATOM   1435 C CG2 . VAL A 1 186 ? -16.85699 6.57658  -24.25123 1.000 19.31875 ? 186 VAL A CG2 1 
ATOM   1436 N N   . ASP A 1 187 ? -15.87216 8.84785  -27.27549 1.000 13.25356 ? 187 ASP A N   1 
ATOM   1437 C CA  . ASP A 1 187 ? -16.62371 9.98251  -27.81129 1.000 14.90947 ? 187 ASP A CA  1 
ATOM   1438 C C   . ASP A 1 187 ? -18.11995 9.66807  -27.78432 1.000 16.96864 ? 187 ASP A C   1 
ATOM   1439 O O   . ASP A 1 187 ? -18.79080 9.48871  -28.80696 1.000 17.03656 ? 187 ASP A O   1 
ATOM   1440 C CB  . ASP A 1 187 ? -16.12696 10.36458 -29.20165 1.000 16.34781 ? 187 ASP A CB  1 
ATOM   1441 C CG  . ASP A 1 187 ? -16.09557 9.20295  -30.17977 1.000 20.75233 ? 187 ASP A CG  1 
ATOM   1442 O OD1 . ASP A 1 187 ? -16.14011 8.03515  -29.75695 1.000 19.37197 ? 187 ASP A OD1 1 
ATOM   1443 O OD2 . ASP A 1 187 ? -16.00447 9.48003  -31.39158 1.000 16.43351 ? 187 ASP A OD2 1 
ATOM   1444 N N   . ARG A 1 188 ? -18.63231 9.61349  -26.56008 1.000 15.06230 ? 188 ARG A N   1 
ATOM   1445 C CA  . ARG A 1 188 ? -20.04619 9.39207  -26.29818 1.000 16.73185 ? 188 ARG A CA  1 
ATOM   1446 C C   . ARG A 1 188 ? -20.45940 10.29151 -25.14670 1.000 15.06176 ? 188 ARG A C   1 
ATOM   1447 O O   . ARG A 1 188 ? -19.68997 10.49307 -24.20390 1.000 17.61060 ? 188 ARG A O   1 
ATOM   1448 C CB  . ARG A 1 188 ? -20.33595 7.92120  -25.95763 1.000 21.98704 ? 188 ARG A CB  1 
ATOM   1449 C CG  . ARG A 1 188 ? -19.55040 6.94019  -26.81909 1.000 35.69143 ? 188 ARG A CG  1 
ATOM   1450 C CD  . ARG A 1 188 ? -19.75086 5.49455  -26.38619 1.000 29.27285 ? 188 ARG A CD  1 
ATOM   1451 N NE  . ARG A 1 188 ? -21.05547 4.97981  -26.78221 1.000 45.57294 ? 188 ARG A NE  1 
ATOM   1452 C CZ  . ARG A 1 188 ? -21.33005 4.48129  -27.98021 1.000 36.21083 ? 188 ARG A CZ  1 
ATOM   1453 N NH1 . ARG A 1 188 ? -20.41544 4.43517  -28.93780 1.000 33.69175 ? 188 ARG A NH1 1 
ATOM   1454 N NH2 . ARG A 1 188 ? -22.55204 4.01936  -28.22458 1.000 28.65388 ? 188 ARG A NH2 1 
ATOM   1455 N N   . GLN A 1 189 ? -21.67152 10.83710 -25.22680 1.000 14.29993 ? 189 GLN A N   1 
ATOM   1456 C CA  . GLN A 1 189 ? -22.16145 11.76167 -24.20654 1.000 17.61399 ? 189 GLN A CA  1 
ATOM   1457 C C   . GLN A 1 189 ? -22.70788 10.95422 -23.03191 1.000 19.75855 ? 189 GLN A C   1 
ATOM   1458 O O   . GLN A 1 189 ? -23.90747 10.68884 -22.90704 1.000 18.13618 ? 189 GLN A O   1 
ATOM   1459 C CB  . GLN A 1 189 ? -23.20249 12.69719 -24.79292 1.000 17.22701 ? 189 GLN A CB  1 
ATOM   1460 C CG  . GLN A 1 189 ? -23.58319 13.82303 -23.85901 1.000 19.57526 ? 189 GLN A CG  1 
ATOM   1461 C CD  . GLN A 1 189 ? -24.28570 14.94762 -24.58303 1.000 18.13254 ? 189 GLN A CD  1 
ATOM   1462 O OE1 . GLN A 1 189 ? -24.43618 14.91905 -25.80359 1.000 20.35056 ? 189 GLN A OE1 1 
ATOM   1463 N NE2 . GLN A 1 189 ? -24.71974 15.94659 -23.83475 1.000 20.92187 ? 189 GLN A NE2 1 
ATOM   1464 N N   . THR A 1 190 ? -21.78758 10.56742 -22.15187 1.000 15.42632 ? 190 THR A N   1 
ATOM   1465 C CA  . THR A 1 190 ? -22.06177 9.66512  -21.04617 1.000 16.51777 ? 190 THR A CA  1 
ATOM   1466 C C   . THR A 1 190 ? -21.32843 10.17351 -19.81706 1.000 20.03359 ? 190 THR A C   1 
ATOM   1467 O O   . THR A 1 190 ? -20.55384 11.12870 -19.88398 1.000 22.63934 ? 190 THR A O   1 
ATOM   1468 C CB  . THR A 1 190 ? -21.61937 8.23156  -21.36701 1.000 19.76174 ? 190 THR A CB  1 
ATOM   1469 O OG1 . THR A 1 190 ? -20.20988 8.21938  -21.63821 1.000 20.09611 ? 190 THR A OG1 1 
ATOM   1470 C CG2 . THR A 1 190 ? -22.35582 7.71522  -22.59110 1.000 22.38086 ? 190 THR A CG2 1 
ATOM   1471 N N   . ALA A 1 191 ? -21.57167 9.51714  -18.68730 1.000 18.47324 ? 191 ALA A N   1 
ATOM   1472 C CA  . ALA A 1 191 ? -20.95417 9.91802  -17.42848 1.000 14.87647 ? 191 ALA A CA  1 
ATOM   1473 C C   . ALA A 1 191 ? -19.50739 9.45399  -17.45432 1.000 19.97185 ? 191 ALA A C   1 
ATOM   1474 O O   . ALA A 1 191 ? -19.21043 8.27689  -17.23668 1.000 30.80005 ? 191 ALA A O   1 
ATOM   1475 C CB  . ALA A 1 191 ? -21.70055 9.33996  -16.23317 1.000 17.76819 ? 191 ALA A CB  1 
ATOM   1476 N N   . GLN A 1 192 ? -18.60543 10.37525 -17.75479 1.000 19.07082 ? 192 GLN A N   1 
ATOM   1477 C CA  . GLN A 1 192 ? -17.17976 10.09723 -17.75634 1.000 15.17221 ? 192 GLN A CA  1 
ATOM   1478 C C   . GLN A 1 192 ? -16.49753 11.14366 -16.90312 1.000 17.14551 ? 192 GLN A C   1 
ATOM   1479 O O   . GLN A 1 192 ? -16.94894 12.28656 -16.82732 1.000 18.01711 ? 192 GLN A O   1 
ATOM   1480 C CB  . GLN A 1 192 ? -16.59700 10.11539 -19.17638 1.000 16.53044 ? 192 GLN A CB  1 
ATOM   1481 C CG  . GLN A 1 192 ? -17.28791 9.16932  -20.13716 1.000 19.32229 ? 192 GLN A CG  1 
ATOM   1482 C CD  . GLN A 1 192 ? -16.68302 9.22441  -21.53107 1.000 17.90075 ? 192 GLN A CD  1 
ATOM   1483 O OE1 . GLN A 1 192 ? -15.49154 8.95615  -21.71523 1.000 17.03688 ? 192 GLN A OE1 1 
ATOM   1484 N NE2 . GLN A 1 192 ? -17.50033 9.58742  -22.51659 1.000 17.75952 ? 192 GLN A NE2 1 
ATOM   1485 N N   . ALA A 1 193 ? -15.41595 10.73684 -16.25118 1.000 20.53400 ? 193 ALA A N   1 
ATOM   1486 C CA  . ALA A 1 193 ? -14.64393 11.63615 -15.41216 1.000 18.41028 ? 193 ALA A CA  1 
ATOM   1487 C C   . ALA A 1 193 ? -13.17393 11.29969 -15.55300 1.000 18.16337 ? 193 ALA A C   1 
ATOM   1488 O O   . ALA A 1 193 ? -12.80670 10.13047 -15.71034 1.000 21.41257 ? 193 ALA A O   1 
ATOM   1489 C CB  . ALA A 1 193 ? -15.05682 11.53909 -13.94110 1.000 16.34426 ? 193 ALA A CB  1 
ATOM   1490 N N   . ALA A 1 194 ? -12.34216 12.33308 -15.50547 1.000 18.51521 ? 194 ALA A N   1 
ATOM   1491 C CA  . ALA A 1 194 ? -10.90280 12.12762 -15.47909 1.000 17.21998 ? 194 ALA A CA  1 
ATOM   1492 C C   . ALA A 1 194 ? -10.46529 11.63134 -14.10830 1.000 18.82472 ? 194 ALA A C   1 
ATOM   1493 O O   . ALA A 1 194 ? -11.06022 11.96694 -13.08047 1.000 22.05060 ? 194 ALA A O   1 
ATOM   1494 C CB  . ALA A 1 194 ? -10.17475 13.42404 -15.82094 1.000 21.41981 ? 194 ALA A CB  1 
ATOM   1495 N N   . GLY A 1 195 ? -9.42564  10.80709 -14.10303 1.000 20.73361 ? 195 GLY A N   1 
ATOM   1496 C CA  . GLY A 1 195 ? -8.83087  10.39140 -12.85406 1.000 23.14203 ? 195 GLY A CA  1 
ATOM   1497 C C   . GLY A 1 195 ? -8.11761  11.54030 -12.16933 1.000 20.57503 ? 195 GLY A C   1 
ATOM   1498 O O   . GLY A 1 195 ? -7.99213  12.65004 -12.69061 1.000 19.16528 ? 195 GLY A O   1 
ATOM   1499 N N   . THR A 1 196 ? -7.65999  11.26912 -10.95036 1.000 19.96109 ? 196 THR A N   1 
ATOM   1500 C CA  . THR A 1 196 ? -6.87249  12.25956 -10.23505 1.000 25.71349 ? 196 THR A CA  1 
ATOM   1501 C C   . THR A 1 196 ? -5.61248  12.58564 -11.02830 1.000 20.29508 ? 196 THR A C   1 
ATOM   1502 O O   . THR A 1 196 ? -4.95772  11.69610 -11.57597 1.000 26.39441 ? 196 THR A O   1 
ATOM   1503 C CB  . THR A 1 196 ? -6.51472  11.74148 -8.84390  1.000 34.29388 ? 196 THR A CB  1 
ATOM   1504 O OG1 . THR A 1 196 ? -7.71835  11.56426 -8.08328  1.000 34.78654 ? 196 THR A OG1 1 
ATOM   1505 C CG2 . THR A 1 196 ? -5.59398  12.72283 -8.12438  1.000 30.95951 ? 196 THR A CG2 1 
ATOM   1506 N N   . ASP A 1 197 ? -5.29107  13.87197 -11.10867 1.000 19.37201 ? 197 ASP A N   1 
ATOM   1507 C CA  . ASP A 1 197 ? -4.11214  14.32520 -11.83211 1.000 16.25494 ? 197 ASP A CA  1 
ATOM   1508 C C   . ASP A 1 197 ? -2.90360  14.36253 -10.90507 1.000 22.80880 ? 197 ASP A C   1 
ATOM   1509 O O   . ASP A 1 197 ? -3.01364  14.22855 -9.68827  1.000 19.11314 ? 197 ASP A O   1 
ATOM   1510 C CB  . ASP A 1 197 ? -4.35443  15.70613 -12.43777 1.000 17.54682 ? 197 ASP A CB  1 
ATOM   1511 C CG  . ASP A 1 197 ? -3.44225  15.99911 -13.62490 1.000 18.32219 ? 197 ASP A CG  1 
ATOM   1512 O OD1 . ASP A 1 197 ? -2.82221  15.05405 -14.16191 1.000 18.41324 ? 197 ASP A OD1 1 
ATOM   1513 O OD2 . ASP A 1 197 ? -3.35165  17.17551 -14.01960 1.000 22.88223 ? 197 ASP A OD2 1 
ATOM   1514 N N   . THR A 1 198 ? -1.73133  14.54535 -11.50626 1.000 17.01914 ? 198 THR A N   1 
ATOM   1515 C CA  A THR A 1 198 ? -0.47498  14.60715 -10.77256 0.500 16.70458 ? 198 THR A CA  1 
ATOM   1516 C CA  B THR A 1 198 ? -0.47583  14.60561 -10.77739 0.500 16.71184 ? 198 THR A CA  1 
ATOM   1517 C C   . THR A 1 198 ? 0.37458   15.72831 -11.35549 1.000 15.01562 ? 198 THR A C   1 
ATOM   1518 O O   . THR A 1 198 ? 0.21449   16.11381 -12.51603 1.000 16.07174 ? 198 THR A O   1 
ATOM   1519 C CB  A THR A 1 198 ? 0.29530   13.27849 -10.83301 0.500 22.49833 ? 198 THR A CB  1 
ATOM   1520 C CB  B THR A 1 198 ? 0.27414   13.26508 -10.84798 0.500 22.49702 ? 198 THR A CB  1 
ATOM   1521 O OG1 A THR A 1 198 ? 1.04542   13.21250 -12.05071 0.500 21.27088 ? 198 THR A OG1 1 
ATOM   1522 O OG1 B THR A 1 198 ? -0.57657  12.21931 -10.36051 0.500 27.92085 ? 198 THR A OG1 1 
ATOM   1523 C CG2 A THR A 1 198 ? -0.66526  12.10231 -10.78795 0.500 19.90367 ? 198 THR A CG2 1 
ATOM   1524 C CG2 B THR A 1 198 ? 1.53516   13.30517 -10.00703 0.500 15.91594 ? 198 THR A CG2 1 
ATOM   1525 N N   . THR A 1 199 ? 1.26963   16.26340 -10.52939 1.000 13.15040 ? 199 THR A N   1 
ATOM   1526 C CA  . THR A 1 199 ? 2.15287   17.34248 -10.95553 1.000 14.30340 ? 199 THR A CA  1 
ATOM   1527 C C   . THR A 1 199 ? 3.33623   16.77408 -11.73801 1.000 12.26915 ? 199 THR A C   1 
ATOM   1528 O O   . THR A 1 199 ? 3.89349   15.73691 -11.37838 1.000 14.38288 ? 199 THR A O   1 
ATOM   1529 C CB  . THR A 1 199 ? 2.63117   18.14235 -9.73676  1.000 14.16109 ? 199 THR A CB  1 
ATOM   1530 O OG1 . THR A 1 199 ? 1.50656   18.75201 -9.08514  1.000 13.64169 ? 199 THR A OG1 1 
ATOM   1531 C CG2 . THR A 1 199 ? 3.60994   19.23332 -10.14579 1.000 13.49855 ? 199 THR A CG2 1 
ATOM   1532 N N   . ILE A 1 200 ? 3.69767   17.44267 -12.83496 1.000 11.36984 ? 200 ILE A N   1 
ATOM   1533 C CA  . ILE A 1 200 ? 4.71994   16.93505 -13.76487 1.000 10.00682 ? 200 ILE A CA  1 
ATOM   1534 C C   . ILE A 1 200 ? 6.07896   17.38888 -13.23129 1.000 14.18649 ? 200 ILE A C   1 
ATOM   1535 O O   . ILE A 1 200 ? 6.57710   18.46729 -13.55167 1.000 13.64382 ? 200 ILE A O   1 
ATOM   1536 C CB  . ILE A 1 200 ? 4.47619   17.40249 -15.19625 1.000 11.39615 ? 200 ILE A CB  1 
ATOM   1537 C CG1 . ILE A 1 200 ? 3.04631   17.07478 -15.63422 1.000 15.21010 ? 200 ILE A CG1 1 
ATOM   1538 C CG2 . ILE A 1 200 ? 5.50290   16.76180 -16.15830 1.000 14.17013 ? 200 ILE A CG2 1 
ATOM   1539 C CD1 . ILE A 1 200 ? 2.52591   17.94694 -16.76127 1.000 13.00613 ? 200 ILE A CD1 1 
ATOM   1540 N N   . THR A 1 201 ? 6.71470   16.50475 -12.45957 1.000 11.61595 ? 201 THR A N   1 
ATOM   1541 C CA  . THR A 1 201 ? 7.92285   16.84309 -11.70215 1.000 9.82977  ? 201 THR A CA  1 
ATOM   1542 C C   . THR A 1 201 ? 9.05292   17.37557 -12.58407 1.000 10.97146 ? 201 THR A C   1 
ATOM   1543 O O   . THR A 1 201 ? 9.69204   18.38310 -12.25280 1.000 12.89605 ? 201 THR A O   1 
ATOM   1544 C CB  . THR A 1 201 ? 8.38940   15.60069 -10.95102 1.000 15.50711 ? 201 THR A CB  1 
ATOM   1545 O OG1 . THR A 1 201 ? 7.29950   15.11901 -10.16588 1.000 12.66859 ? 201 THR A OG1 1 
ATOM   1546 C CG2 . THR A 1 201 ? 9.57852   15.90316 -10.04510 1.000 12.33255 ? 201 THR A CG2 1 
ATOM   1547 N N   . VAL A 1 202 ? 9.34809   16.68535 -13.68790 1.000 10.67617 ? 202 VAL A N   1 
ATOM   1548 C CA  . VAL A 1 202 ? 10.45370  17.10742 -14.54676 1.000 9.76047  ? 202 VAL A CA  1 
ATOM   1549 C C   . VAL A 1 202 ? 10.21287  18.50658 -15.10863 1.000 10.15727 ? 202 VAL A C   1 
ATOM   1550 O O   . VAL A 1 202 ? 11.16598  19.26820 -15.33073 1.000 11.69153 ? 202 VAL A O   1 
ATOM   1551 C CB  . VAL A 1 202 ? 10.67745  16.06151 -15.65943 1.000 10.79783 ? 202 VAL A CB  1 
ATOM   1552 C CG1 . VAL A 1 202 ? 9.48585   16.01071 -16.61304 1.000 14.55282 ? 202 VAL A CG1 1 
ATOM   1553 C CG2 . VAL A 1 202 ? 11.97069  16.35350 -16.41859 1.000 13.50894 ? 202 VAL A CG2 1 
ATOM   1554 N N   . ASN A 1 203 ? 8.94611   18.87519 -15.33747 1.000 12.77520 ? 203 ASN A N   1 
ATOM   1555 C CA  . ASN A 1 203 ? 8.64914   20.20877 -15.85351 1.000 11.26248 ? 203 ASN A CA  1 
ATOM   1556 C C   . ASN A 1 203 ? 8.84426   21.27588 -14.78575 1.000 10.10280 ? 203 ASN A C   1 
ATOM   1557 O O   . ASN A 1 203 ? 9.31942   22.37931 -15.08491 1.000 13.45358 ? 203 ASN A O   1 
ATOM   1558 C CB  . ASN A 1 203 ? 7.22132   20.26815 -16.39651 1.000 10.44601 ? 203 ASN A CB  1 
ATOM   1559 C CG  . ASN A 1 203 ? 7.06259   19.50886 -17.69378 1.000 12.70308 ? 203 ASN A CG  1 
ATOM   1560 O OD1 . ASN A 1 203 ? 8.00957   18.88948 -18.18692 1.000 13.66095 ? 203 ASN A OD1 1 
ATOM   1561 N ND2 . ASN A 1 203 ? 5.85381   19.54266 -18.25534 1.000 11.96866 ? 203 ASN A ND2 1 
ATOM   1562 N N   . VAL A 1 204 ? 8.47755   20.97496 -13.53534 1.000 10.58817 ? 204 VAL A N   1 
ATOM   1563 C CA  . VAL A 1 204 ? 8.73253   21.92351 -12.45564 1.000 9.03556  ? 204 VAL A CA  1 
ATOM   1564 C C   . VAL A 1 204 ? 10.22627  22.19272 -12.34905 1.000 10.45964 ? 204 VAL A C   1 
ATOM   1565 O O   . VAL A 1 204 ? 10.66557  23.34288 -12.23379 1.000 13.04998 ? 204 VAL A O   1 
ATOM   1566 C CB  . VAL A 1 204 ? 8.16712   21.40306 -11.12208 1.000 12.66565 ? 204 VAL A CB  1 
ATOM   1567 C CG1 . VAL A 1 204 ? 8.59497   22.33698 -10.01360 1.000 11.39944 ? 204 VAL A CG1 1 
ATOM   1568 C CG2 . VAL A 1 204 ? 6.65203   21.32326 -11.18178 1.000 14.69417 ? 204 VAL A CG2 1 
ATOM   1569 N N   . LEU A 1 205 ? 11.03019  21.12592 -12.39266 1.000 10.75747 ? 205 LEU A N   1 
ATOM   1570 C CA  . LEU A 1 205 ? 12.48244  21.28487 -12.35759 1.000 10.52083 ? 205 LEU A CA  1 
ATOM   1571 C C   . LEU A 1 205 ? 12.96718  22.14891 -13.51848 1.000 10.42331 ? 205 LEU A C   1 
ATOM   1572 O O   . LEU A 1 205 ? 13.78692  23.05388 -13.33007 1.000 12.12546 ? 205 LEU A O   1 
ATOM   1573 C CB  . LEU A 1 205 ? 13.16004  19.91319 -12.38475 1.000 13.64965 ? 205 LEU A CB  1 
ATOM   1574 C CG  . LEU A 1 205 ? 12.95153  19.09621 -11.09878 1.000 13.39633 ? 205 LEU A CG  1 
ATOM   1575 C CD1 . LEU A 1 205 ? 13.39907  17.64347 -11.24456 1.000 13.78384 ? 205 LEU A CD1 1 
ATOM   1576 C CD2 . LEU A 1 205 ? 13.68357  19.76003 -9.94718  1.000 12.29163 ? 205 LEU A CD2 1 
ATOM   1577 N N   . ALA A 1 206 ? 12.45557  21.88981 -14.72896 1.000 12.51401 ? 206 ALA A N   1 
ATOM   1578 C CA  . ALA A 1 206 ? 12.83995  22.70405 -15.87983 1.000 14.47887 ? 206 ALA A CA  1 
ATOM   1579 C C   . ALA A 1 206 ? 12.53752  24.17458 -15.63215 1.000 12.07851 ? 206 ALA A C   1 
ATOM   1580 O O   . ALA A 1 206 ? 13.35805  25.05096 -15.93005 1.000 12.64689 ? 206 ALA A O   1 
ATOM   1581 C CB  . ALA A 1 206 ? 12.11195  22.21514 -17.13282 1.000 11.80290 ? 206 ALA A CB  1 
ATOM   1582 N N   . TRP A 1 207 ? 11.35682  24.45882 -15.08068 1.000 9.87081  ? 207 TRP A N   1 
ATOM   1583 C CA  . TRP A 1 207 ? 10.95564  25.83119 -14.81509 1.000 9.03097  ? 207 TRP A CA  1 
ATOM   1584 C C   . TRP A 1 207 ? 11.80973  26.46973 -13.71769 1.000 12.13787 ? 207 TRP A C   1 
ATOM   1585 O O   . TRP A 1 207 ? 12.06303  27.67782 -13.76144 1.000 12.67262 ? 207 TRP A O   1 
ATOM   1586 C CB  . TRP A 1 207 ? 9.46846   25.82605 -14.46216 1.000 10.81577 ? 207 TRP A CB  1 
ATOM   1587 C CG  . TRP A 1 207 ? 8.88614   27.10227 -14.01235 1.000 14.69559 ? 207 TRP A CG  1 
ATOM   1588 C CD1 . TRP A 1 207 ? 8.52324   28.16859 -14.78754 1.000 14.63442 ? 207 TRP A CD1 1 
ATOM   1589 C CD2 . TRP A 1 207 ? 8.53521   27.43787 -12.67344 1.000 12.04903 ? 207 TRP A CD2 1 
ATOM   1590 N NE1 . TRP A 1 207 ? 7.98622   29.15907 -14.00134 1.000 16.70181 ? 207 TRP A NE1 1 
ATOM   1591 C CE2 . TRP A 1 207 ? 7.97889   28.73501 -12.70013 1.000 14.68045 ? 207 TRP A CE2 1 
ATOM   1592 C CE3 . TRP A 1 207 ? 8.63663   26.77022 -11.44976 1.000 15.24791 ? 207 TRP A CE3 1 
ATOM   1593 C CZ2 . TRP A 1 207 ? 7.53504   29.37779 -11.54714 1.000 18.36994 ? 207 TRP A CZ2 1 
ATOM   1594 C CZ3 . TRP A 1 207 ? 8.19642   27.41319 -10.30877 1.000 15.29323 ? 207 TRP A CZ3 1 
ATOM   1595 C CH2 . TRP A 1 207 ? 7.65426   28.70183 -10.36782 1.000 14.76524 ? 207 TRP A CH2 1 
ATOM   1596 N N   . LEU A 1 208 ? 12.29403  25.67981 -12.74884 1.000 10.39665 ? 208 LEU A N   1 
ATOM   1597 C CA  . LEU A 1 208 ? 13.22815  26.22614 -11.76651 1.000 11.29273 ? 208 LEU A CA  1 
ATOM   1598 C C   . LEU A 1 208 ? 14.56226  26.59596 -12.40958 1.000 10.62896 ? 208 LEU A C   1 
ATOM   1599 O O   . LEU A 1 208 ? 15.18445  27.58758 -12.01397 1.000 11.10002 ? 208 LEU A O   1 
ATOM   1600 C CB  . LEU A 1 208 ? 13.44919  25.24307 -10.61243 1.000 9.11317  ? 208 LEU A CB  1 
ATOM   1601 C CG  . LEU A 1 208 ? 12.23545  24.97383 -9.70301  1.000 10.45419 ? 208 LEU A CG  1 
ATOM   1602 C CD1 . LEU A 1 208 ? 12.61098  23.97017 -8.61394  1.000 12.63201 ? 208 LEU A CD1 1 
ATOM   1603 C CD2 . LEU A 1 208 ? 11.71294  26.26910 -9.07067  1.000 12.67829 ? 208 LEU A CD2 1 
ATOM   1604 N N   . TYR A 1 209 ? 15.03585  25.79627 -13.37213 1.000 13.10932 ? 209 TYR A N   1 
ATOM   1605 C CA  . TYR A 1 209 ? 16.20669  26.19815 -14.15059 1.000 10.92390 ? 209 TYR A CA  1 
ATOM   1606 C C   . TYR A 1 209 ? 15.93773  27.48385 -14.91902 1.000 11.87671 ? 209 TYR A C   1 
ATOM   1607 O O   . TYR A 1 209 ? 16.79998  28.36633 -14.97517 1.000 13.28618 ? 209 TYR A O   1 
ATOM   1608 C CB  . TYR A 1 209 ? 16.62499  25.08308 -15.11682 1.000 12.80574 ? 209 TYR A CB  1 
ATOM   1609 C CG  . TYR A 1 209 ? 17.39316  23.95941 -14.46522 1.000 10.74220 ? 209 TYR A CG  1 
ATOM   1610 C CD1 . TYR A 1 209 ? 18.72266  24.13307 -14.07422 1.000 10.21699 ? 209 TYR A CD1 1 
ATOM   1611 C CD2 . TYR A 1 209 ? 16.80233  22.73174 -14.23990 1.000 10.92364 ? 209 TYR A CD2 1 
ATOM   1612 C CE1 . TYR A 1 209 ? 19.43904  23.09973 -13.47232 1.000 10.36614 ? 209 TYR A CE1 1 
ATOM   1613 C CE2 . TYR A 1 209 ? 17.50472  21.69351 -13.63771 1.000 14.22040 ? 209 TYR A CE2 1 
ATOM   1614 C CZ  . TYR A 1 209 ? 18.81984  21.88631 -13.25871 1.000 15.12720 ? 209 TYR A CZ  1 
ATOM   1615 O OH  . TYR A 1 209 ? 19.51902  20.86327 -12.65703 1.000 12.14051 ? 209 TYR A OH  1 
ATOM   1616 N N   . ALA A 1 210 ? 14.74518  27.60992 -15.52233 1.000 12.60065 ? 210 ALA A N   1 
ATOM   1617 C CA  . ALA A 1 210 ? 14.39667  28.86284 -16.19111 1.000 11.32749 ? 210 ALA A CA  1 
ATOM   1618 C C   . ALA A 1 210 ? 14.50734  30.03543 -15.22903 1.000 10.45684 ? 210 ALA A C   1 
ATOM   1619 O O   . ALA A 1 210 ? 14.98516  31.11280 -15.59947 1.000 13.44248 ? 210 ALA A O   1 
ATOM   1620 C CB  . ALA A 1 210 ? 12.97958  28.79462 -16.77543 1.000 12.01197 ? 210 ALA A CB  1 
ATOM   1621 N N   . ALA A 1 211 ? 14.05548  29.84318 -13.98535 1.000 12.72770 ? 211 ALA A N   1 
ATOM   1622 C CA  . ALA A 1 211 ? 14.12816  30.90627 -12.99078 1.000 12.27680 ? 211 ALA A CA  1 
ATOM   1623 C C   . ALA A 1 211 ? 15.57476  31.31078 -12.72189 1.000 14.76411 ? 211 ALA A C   1 
ATOM   1624 O O   . ALA A 1 211 ? 15.89474  32.50211 -12.67590 1.000 13.74854 ? 211 ALA A O   1 
ATOM   1625 C CB  . ALA A 1 211 ? 13.43572  30.46417 -11.69910 1.000 12.85773 ? 211 ALA A CB  1 
ATOM   1626 N N   . VAL A 1 212 ? 16.46440  30.32953 -12.54642 1.000 11.54637 ? 212 VAL A N   1 
ATOM   1627 C CA  . VAL A 1 212 ? 17.87916  30.62687 -12.31668 1.000 12.71511 ? 212 VAL A CA  1 
ATOM   1628 C C   . VAL A 1 212 ? 18.45131  31.42210 -13.48281 1.000 12.22928 ? 212 VAL A C   1 
ATOM   1629 O O   . VAL A 1 212 ? 19.16260  32.41875 -13.29118 1.000 14.02992 ? 212 VAL A O   1 
ATOM   1630 C CB  . VAL A 1 212 ? 18.66375  29.32702 -12.08496 1.000 12.15251 ? 212 VAL A CB  1 
ATOM   1631 C CG1 . VAL A 1 212 ? 20.17425  29.61161 -12.03486 1.000 14.66097 ? 212 VAL A CG1 1 
ATOM   1632 C CG2 . VAL A 1 212 ? 18.19197  28.65290 -10.80337 1.000 13.12923 ? 212 VAL A CG2 1 
ATOM   1633 N N   . ILE A 1 213 ? 18.14199  30.99804 -14.71098 1.000 13.00522 ? 213 ILE A N   1 
ATOM   1634 C CA  . ILE A 1 213 ? 18.65394  31.69698 -15.88670 1.000 15.13638 ? 213 ILE A CA  1 
ATOM   1635 C C   . ILE A 1 213 ? 18.17865  33.14250 -15.90401 1.000 15.00326 ? 213 ILE A C   1 
ATOM   1636 O O   . ILE A 1 213 ? 18.89948  34.03764 -16.36721 1.000 18.24680 ? 213 ILE A O   1 
ATOM   1637 C CB  . ILE A 1 213 ? 18.24981  30.93800 -17.16679 1.000 11.95125 ? 213 ILE A CB  1 
ATOM   1638 C CG1 . ILE A 1 213 ? 18.95450  29.58087 -17.20760 1.000 13.82603 ? 213 ILE A CG1 1 
ATOM   1639 C CG2 . ILE A 1 213 ? 18.55919  31.75677 -18.41353 1.000 17.13614 ? 213 ILE A CG2 1 
ATOM   1640 C CD1 . ILE A 1 213 ? 18.48864  28.68621 -18.32891 1.000 16.84244 ? 213 ILE A CD1 1 
ATOM   1641 N N   . ASN A 1 214 ? 16.97691  33.40399 -15.39075 1.000 12.47236 ? 214 ASN A N   1 
ATOM   1642 C CA  . ASN A 1 214 ? 16.46197  34.76242 -15.31466 1.000 15.03595 ? 214 ASN A CA  1 
ATOM   1643 C C   . ASN A 1 214 ? 16.88083  35.49517 -14.04619 1.000 15.09499 ? 214 ASN A C   1 
ATOM   1644 O O   . ASN A 1 214 ? 16.43492  36.62898 -13.83179 1.000 20.26232 ? 214 ASN A O   1 
ATOM   1645 C CB  . ASN A 1 214 ? 14.93663  34.74828 -15.43630 1.000 17.07621 ? 214 ASN A CB  1 
ATOM   1646 C CG  . ASN A 1 214 ? 14.48368  34.73731 -16.87464 1.000 23.07016 ? 214 ASN A CG  1 
ATOM   1647 O OD1 . ASN A 1 214 ? 14.18212  35.78605 -17.44113 1.000 28.39577 ? 214 ASN A OD1 1 
ATOM   1648 N ND2 . ASN A 1 214 ? 14.47110  33.55257 -17.49077 1.000 18.81806 ? 214 ASN A ND2 1 
ATOM   1649 N N   . GLY A 1 215 ? 17.72561  34.88967 -13.20776 1.000 13.83181 ? 215 GLY A N   1 
ATOM   1650 C CA  . GLY A 1 215 ? 18.20308  35.56369 -12.01459 1.000 13.85013 ? 215 GLY A CA  1 
ATOM   1651 C C   . GLY A 1 215 ? 17.30410  35.48169 -10.80374 1.000 15.89996 ? 215 GLY A C   1 
ATOM   1652 O O   . GLY A 1 215 ? 17.53790  36.20711 -9.82917  1.000 16.63795 ? 215 GLY A O   1 
ATOM   1653 N N   . ASP A 1 216 ? 16.27708  34.63719 -10.83029 1.000 13.09019 ? 216 ASP A N   1 
ATOM   1654 C CA  . ASP A 1 216 ? 15.40456  34.42194 -9.67468  1.000 15.53096 ? 216 ASP A CA  1 
ATOM   1655 C C   . ASP A 1 216 ? 15.92139  33.16600 -8.97817  1.000 19.25692 ? 216 ASP A C   1 
ATOM   1656 O O   . ASP A 1 216 ? 15.56122  32.04417 -9.33762  1.000 17.06270 ? 216 ASP A O   1 
ATOM   1657 C CB  . ASP A 1 216 ? 13.95314  34.28733 -10.12608 1.000 14.37290 ? 216 ASP A CB  1 
ATOM   1658 C CG  . ASP A 1 216 ? 12.95312  34.78051 -9.09287  1.000 21.47546 ? 216 ASP A CG  1 
ATOM   1659 O OD1 . ASP A 1 216 ? 13.35133  35.18396 -7.97855  1.000 20.48136 ? 216 ASP A OD1 1 
ATOM   1660 O OD2 . ASP A 1 216 ? 11.74785  34.77102 -9.41730  1.000 17.41845 ? 216 ASP A OD2 1 
ATOM   1661 N N   . ARG A 1 217 ? 16.79303  33.36381 -7.98198  1.000 15.32887 ? 217 ARG A N   1 
ATOM   1662 C CA  . ARG A 1 217 ? 17.60598  32.29502 -7.41660  1.000 13.47250 ? 217 ARG A CA  1 
ATOM   1663 C C   . ARG A 1 217 ? 17.37905  32.02318 -5.93239  1.000 10.82722 ? 217 ARG A C   1 
ATOM   1664 O O   . ARG A 1 217 ? 18.08702  31.18298 -5.36285  1.000 14.92773 ? 217 ARG A O   1 
ATOM   1665 C CB  . ARG A 1 217 ? 19.10025  32.61074 -7.62687  1.000 12.38212 ? 217 ARG A CB  1 
ATOM   1666 C CG  . ARG A 1 217 ? 19.53783  32.65914 -9.08544  1.000 17.06586 ? 217 ARG A CG  1 
ATOM   1667 C CD  . ARG A 1 217 ? 21.03058  33.03250 -9.22044  1.000 17.15685 ? 217 ARG A CD  1 
ATOM   1668 N NE  . ARG A 1 217 ? 21.21912  34.47951 -9.16543  1.000 25.42863 ? 217 ARG A NE  1 
ATOM   1669 C CZ  . ARG A 1 217 ? 21.48673  35.16769 -8.06427  1.000 21.86821 ? 217 ARG A CZ  1 
ATOM   1670 N NH1 . ARG A 1 217 ? 21.69785  34.56633 -6.90611  1.000 28.74961 ? 217 ARG A NH1 1 
ATOM   1671 N NH2 . ARG A 1 217 ? 21.54178  36.49493 -8.12767  1.000 25.14510 ? 217 ARG A NH2 1 
ATOM   1672 N N   . TRP A 1 218 ? 16.40746  32.67933 -5.29319  1.000 13.83796 ? 218 TRP A N   1 
ATOM   1673 C CA  . TRP A 1 218 ? 16.33842  32.64386 -3.83401  1.000 16.73568 ? 218 TRP A CA  1 
ATOM   1674 C C   . TRP A 1 218 ? 16.14356  31.23432 -3.28499  1.000 12.90400 ? 218 TRP A C   1 
ATOM   1675 O O   . TRP A 1 218 ? 16.55985  30.95421 -2.15554  1.000 15.96773 ? 218 TRP A O   1 
ATOM   1676 C CB  . TRP A 1 218 ? 15.21563  33.55114 -3.33183  1.000 12.01157 ? 218 TRP A CB  1 
ATOM   1677 C CG  . TRP A 1 218 ? 13.82286  33.12812 -3.75524  1.000 13.28843 ? 218 TRP A CG  1 
ATOM   1678 C CD1 . TRP A 1 218 ? 13.12503  33.58053 -4.83617  1.000 14.66813 ? 218 TRP A CD1 1 
ATOM   1679 C CD2 . TRP A 1 218 ? 12.96181  32.19235 -3.08774  1.000 14.32093 ? 218 TRP A CD2 1 
ATOM   1680 N NE1 . TRP A 1 218 ? 11.88964  32.97882 -4.89266  1.000 15.46729 ? 218 TRP A NE1 1 
ATOM   1681 C CE2 . TRP A 1 218 ? 11.76389  32.12659 -3.82519  1.000 15.21704 ? 218 TRP A CE2 1 
ATOM   1682 C CE3 . TRP A 1 218 ? 13.08766  31.41068 -1.93718  1.000 15.26692 ? 218 TRP A CE3 1 
ATOM   1683 C CZ2 . TRP A 1 218 ? 10.70606  31.29358 -3.45917  1.000 13.95395 ? 218 TRP A CZ2 1 
ATOM   1684 C CZ3 . TRP A 1 218 ? 12.03662  30.59181 -1.57012  1.000 12.39809 ? 218 TRP A CZ3 1 
ATOM   1685 C CH2 . TRP A 1 218 ? 10.85835  30.53749 -2.32841  1.000 15.19154 ? 218 TRP A CH2 1 
ATOM   1686 N N   . PHE A 1 219 ? 15.51965  30.34215 -4.04963  1.000 13.19966 ? 219 PHE A N   1 
ATOM   1687 C CA  . PHE A 1 219 ? 15.13575  29.02127 -3.55585  1.000 12.13035 ? 219 PHE A CA  1 
ATOM   1688 C C   . PHE A 1 219 ? 16.27361  28.00580 -3.57984  1.000 10.09353 ? 219 PHE A C   1 
ATOM   1689 O O   . PHE A 1 219 ? 16.08714  26.89068 -3.07981  1.000 16.24858 ? 219 PHE A O   1 
ATOM   1690 C CB  . PHE A 1 219 ? 13.96357  28.48199 -4.38764  1.000 13.12552 ? 219 PHE A CB  1 
ATOM   1691 C CG  . PHE A 1 219 ? 14.23844  28.49683 -5.86582  1.000 9.89462  ? 219 PHE A CG  1 
ATOM   1692 C CD1 . PHE A 1 219 ? 14.85676  27.41698 -6.48855  1.000 10.35660 ? 219 PHE A CD1 1 
ATOM   1693 C CD2 . PHE A 1 219 ? 13.94374  29.62565 -6.61639  1.000 11.77109 ? 219 PHE A CD2 1 
ATOM   1694 C CE1 . PHE A 1 219 ? 15.15645  27.45013 -7.83643  1.000 10.05138 ? 219 PHE A CE1 1 
ATOM   1695 C CE2 . PHE A 1 219 ? 14.23416  29.66827 -7.97159  1.000 12.86767 ? 219 PHE A CE2 1 
ATOM   1696 C CZ  . PHE A 1 219 ? 14.84058  28.57609 -8.58254  1.000 11.32443 ? 219 PHE A CZ  1 
ATOM   1697 N N   . LEU A 1 220 ? 17.41803  28.33597 -4.17255  1.000 12.90452 ? 220 LEU A N   1 
ATOM   1698 C CA  . LEU A 1 220 ? 18.53733  27.40083 -4.21733  1.000 13.18516 ? 220 LEU A CA  1 
ATOM   1699 C C   . LEU A 1 220 ? 19.08229  27.18766 -2.81044  1.000 16.12994 ? 220 LEU A C   1 
ATOM   1700 O O   . LEU A 1 220 ? 19.49291  28.14903 -2.15216  1.000 17.85289 ? 220 LEU A O   1 
ATOM   1701 C CB  . LEU A 1 220 ? 19.62731  27.93883 -5.14389  1.000 12.19333 ? 220 LEU A CB  1 
ATOM   1702 C CG  . LEU A 1 220 ? 19.24376  28.05196 -6.62078  1.000 13.09663 ? 220 LEU A CG  1 
ATOM   1703 C CD1 . LEU A 1 220 ? 20.35056  28.68905 -7.43556  1.000 11.49229 ? 220 LEU A CD1 1 
ATOM   1704 C CD2 . LEU A 1 220 ? 18.85266  26.69089 -7.20379  1.000 14.85246 ? 220 LEU A CD2 1 
ATOM   1705 N N   . ASN A 1 221 ? 19.07948  25.94181 -2.33488  1.000 16.67571 ? 221 ASN A N   1 
ATOM   1706 C CA  . ASN A 1 221 ? 19.64557  25.66722 -1.02373  1.000 14.73137 ? 221 ASN A CA  1 
ATOM   1707 C C   . ASN A 1 221 ? 21.01686  25.00581 -1.17721  1.000 16.35716 ? 221 ASN A C   1 
ATOM   1708 O O   . ASN A 1 221 ? 21.52405  24.80157 -2.28066  1.000 15.76497 ? 221 ASN A O   1 
ATOM   1709 C CB  . ASN A 1 221 ? 18.67485  24.85242 -0.14980  1.000 15.20386 ? 221 ASN A CB  1 
ATOM   1710 C CG  . ASN A 1 221 ? 18.50292  23.39845 -0.58606  1.000 15.32847 ? 221 ASN A CG  1 
ATOM   1711 O OD1 . ASN A 1 221 ? 19.34888  22.81228 -1.25991  1.000 16.44276 ? 221 ASN A OD1 1 
ATOM   1712 N ND2 . ASN A 1 221 ? 17.38779  22.80205 -0.16796  1.000 18.28068 ? 221 ASN A ND2 1 
ATOM   1713 N N   . ARG A 1 222 ? 21.64601  24.70858 -0.04673  1.000 16.11601 ? 222 ARG A N   1 
ATOM   1714 C CA  . ARG A 1 222 ? 23.01794  24.22814 -0.04685  1.000 17.34549 ? 222 ARG A CA  1 
ATOM   1715 C C   . ARG A 1 222 ? 23.12664  22.70821 -0.08702  1.000 20.94518 ? 222 ARG A C   1 
ATOM   1716 O O   . ARG A 1 222 ? 24.23362  22.17911 0.05110   1.000 18.32640 ? 222 ARG A O   1 
ATOM   1717 C CB  . ARG A 1 222 ? 23.75546  24.76358 1.18406   1.000 22.82188 ? 222 ARG A CB  1 
ATOM   1718 C CG  . ARG A 1 222 ? 23.20838  24.26432 2.51123   1.000 29.74952 ? 222 ARG A CG  1 
ATOM   1719 C CD  . ARG A 1 222 ? 23.90613  24.95984 3.68139   1.000 32.72890 ? 222 ARG A CD  1 
ATOM   1720 N NE  . ARG A 1 222 ? 23.52892  24.37884 4.96334   1.000 41.52415 ? 222 ARG A NE  1 
ATOM   1721 C CZ  . ARG A 1 222 ? 22.55820  24.83840 5.74001   1.000 49.73731 ? 222 ARG A CZ  1 
ATOM   1722 N NH1 . ARG A 1 222 ? 21.84427  25.89825 5.39871   1.000 51.01388 ? 222 ARG A NH1 1 
ATOM   1723 N NH2 . ARG A 1 222 ? 22.29853  24.21902 6.88884   1.000 39.13871 ? 222 ARG A NH2 1 
ATOM   1724 N N   . PHE A 1 223 ? 22.02902  21.99523 -0.30049  1.000 16.86489 ? 223 PHE A N   1 
ATOM   1725 C CA  . PHE A 1 223 ? 22.02496  20.55066 -0.12958  1.000 11.67382 ? 223 PHE A CA  1 
ATOM   1726 C C   . PHE A 1 223 ? 21.90110  19.82833 -1.46443  1.000 14.41211 ? 223 PHE A C   1 
ATOM   1727 O O   . PHE A 1 223 ? 21.52932  20.40076 -2.49436  1.000 19.38337 ? 223 PHE A O   1 
ATOM   1728 C CB  . PHE A 1 223 ? 20.87606  20.11107 0.79034   1.000 14.57776 ? 223 PHE A CB  1 
ATOM   1729 C CG  . PHE A 1 223 ? 20.91274  20.72683 2.16016   1.000 21.42960 ? 223 PHE A CG  1 
ATOM   1730 C CD1 . PHE A 1 223 ? 21.94230  20.42986 3.03965   1.000 18.59603 ? 223 PHE A CD1 1 
ATOM   1731 C CD2 . PHE A 1 223 ? 19.90381  21.57937 2.58040   1.000 23.53517 ? 223 PHE A CD2 1 
ATOM   1732 C CE1 . PHE A 1 223 ? 21.97370  20.99052 4.30565   1.000 24.36124 ? 223 PHE A CE1 1 
ATOM   1733 C CE2 . PHE A 1 223 ? 19.93105  22.14230 3.84442   1.000 24.40494 ? 223 PHE A CE2 1 
ATOM   1734 C CZ  . PHE A 1 223 ? 20.96547  21.84604 4.70788   1.000 24.37378 ? 223 PHE A CZ  1 
ATOM   1735 N N   . THR A 1 224 ? 22.20041  18.53950 -1.42007  1.000 15.81333 ? 224 THR A N   1 
ATOM   1736 C CA  . THR A 1 224 ? 21.86824  17.59940 -2.47690  1.000 16.79023 ? 224 THR A CA  1 
ATOM   1737 C C   . THR A 1 224 ? 20.92083  16.54346 -1.91067  1.000 17.79937 ? 224 THR A C   1 
ATOM   1738 O O   . THR A 1 224 ? 20.53601  16.58502 -0.73814  1.000 21.67993 ? 224 THR A O   1 
ATOM   1739 C CB  . THR A 1 224 ? 23.13383  16.96901 -3.07564  1.000 15.62644 ? 224 THR A CB  1 
ATOM   1740 O OG1 . THR A 1 224 ? 22.83079  16.36606 -4.34593  1.000 18.33240 ? 224 THR A OG1 1 
ATOM   1741 C CG2 . THR A 1 224 ? 23.70441  15.91044 -2.15141  1.000 18.19909 ? 224 THR A CG2 1 
ATOM   1742 N N   . THR A 1 225 ? 20.52491  15.60566 -2.76534  1.000 16.37577 ? 225 THR A N   1 
ATOM   1743 C CA  . THR A 1 225 ? 19.67979  14.49478 -2.35609  1.000 16.44267 ? 225 THR A CA  1 
ATOM   1744 C C   . THR A 1 225 ? 19.92123  13.32682 -3.29663  1.000 17.99454 ? 225 THR A C   1 
ATOM   1745 O O   . THR A 1 225 ? 20.46069  13.49015 -4.39277  1.000 18.93793 ? 225 THR A O   1 
ATOM   1746 C CB  . THR A 1 225 ? 18.18532  14.86341 -2.35980  1.000 18.38674 ? 225 THR A CB  1 
ATOM   1747 O OG1 . THR A 1 225 ? 17.42179  13.76563 -1.84271  1.000 30.89103 ? 225 THR A OG1 1 
ATOM   1748 C CG2 . THR A 1 225 ? 17.70564  15.14282 -3.78754  1.000 18.84756 ? 225 THR A CG2 1 
ATOM   1749 N N   . THR A 1 226 ? 19.53102  12.13740 -2.85041  1.000 17.76313 ? 226 THR A N   1 
ATOM   1750 C CA  . THR A 1 226 ? 19.47591  11.01109 -3.76615  1.000 20.67425 ? 226 THR A CA  1 
ATOM   1751 C C   . THR A 1 226 ? 18.15204  11.02290 -4.52004  1.000 18.39851 ? 226 THR A C   1 
ATOM   1752 O O   . THR A 1 226 ? 17.14661  11.57729 -4.06231  1.000 19.51328 ? 226 THR A O   1 
ATOM   1753 C CB  . THR A 1 226 ? 19.61152  9.67591  -3.03572  1.000 19.10726 ? 226 THR A CB  1 
ATOM   1754 O OG1 . THR A 1 226 ? 18.44085  9.45390  -2.23771  1.000 20.48751 ? 226 THR A OG1 1 
ATOM   1755 C CG2 . THR A 1 226 ? 20.85095  9.66665  -2.15359  1.000 18.85547 ? 226 THR A CG2 1 
ATOM   1756 N N   . LEU A 1 227 ? 18.16441  10.39308 -5.69300  1.000 19.75969 ? 227 LEU A N   1 
ATOM   1757 C CA  . LEU A 1 227 ? 16.93658  10.25870 -6.46439  1.000 17.56995 ? 227 LEU A CA  1 
ATOM   1758 C C   . LEU A 1 227 ? 15.85705  9.54889  -5.65533  1.000 15.76883 ? 227 LEU A C   1 
ATOM   1759 O O   . LEU A 1 227 ? 14.69544  9.97783  -5.64168  1.000 17.11996 ? 227 LEU A O   1 
ATOM   1760 C CB  . LEU A 1 227 ? 17.22725  9.50948  -7.76503  1.000 18.23548 ? 227 LEU A CB  1 
ATOM   1761 C CG  . LEU A 1 227 ? 16.12086  9.40162  -8.80226  1.000 19.91022 ? 227 LEU A CG  1 
ATOM   1762 C CD1 . LEU A 1 227 ? 15.65335  10.78175 -9.22953  1.000 16.36097 ? 227 LEU A CD1 1 
ATOM   1763 C CD2 . LEU A 1 227 ? 16.64647  8.62606  -9.99407  1.000 18.49522 ? 227 LEU A CD2 1 
ATOM   1764 N N   . ASN A 1 228 ? 16.22821  8.47199  -4.95587  1.000 21.60004 ? 228 ASN A N   1 
ATOM   1765 C CA  . ASN A 1 228 ? 15.25189  7.72125  -4.17284  1.000 21.03267 ? 228 ASN A CA  1 
ATOM   1766 C C   . ASN A 1 228 ? 14.63385  8.58295  -3.08256  1.000 17.54740 ? 228 ASN A C   1 
ATOM   1767 O O   . ASN A 1 228 ? 13.41022  8.59273  -2.90287  1.000 21.73454 ? 228 ASN A O   1 
ATOM   1768 C CB  . ASN A 1 228 ? 15.90390  6.48172  -3.56031  1.000 29.26687 ? 228 ASN A CB  1 
ATOM   1769 C CG  . ASN A 1 228 ? 16.05334  5.35074  -4.55221  1.000 27.57637 ? 228 ASN A CG  1 
ATOM   1770 O OD1 . ASN A 1 228 ? 15.44985  5.36198  -5.62549  1.000 31.35253 ? 228 ASN A OD1 1 
ATOM   1771 N ND2 . ASN A 1 228 ? 16.86000  4.35565  -4.19436  1.000 45.06981 ? 228 ASN A ND2 1 
ATOM   1772 N N   . ASP A 1 229 ? 15.46451  9.30471  -2.32573  1.000 19.04155 ? 229 ASP A N   1 
ATOM   1773 C CA  A ASP A 1 229 ? 14.92142  10.10535 -1.23638  0.500 19.44581 ? 229 ASP A CA  1 
ATOM   1774 C CA  B ASP A 1 229 ? 14.94565  10.12691 -1.23486  0.500 19.40011 ? 229 ASP A CA  1 
ATOM   1775 C C   . ASP A 1 229 ? 14.06501  11.24962 -1.76612  1.000 18.58772 ? 229 ASP A C   1 
ATOM   1776 O O   . ASP A 1 229 ? 13.04825  11.60216 -1.15376  1.000 23.34483 ? 229 ASP A O   1 
ATOM   1777 C CB  A ASP A 1 229 ? 16.04915  10.61462 -0.34582  0.500 20.66290 ? 229 ASP A CB  1 
ATOM   1778 C CB  B ASP A 1 229 ? 16.09779  10.69877 -0.40768  0.500 20.59304 ? 229 ASP A CB  1 
ATOM   1779 C CG  A ASP A 1 229 ? 16.67343  9.50390  0.47227   0.500 25.66480 ? 229 ASP A CG  1 
ATOM   1780 C CG  B ASP A 1 229 ? 15.61854  11.45692 0.82025   0.500 29.59851 ? 229 ASP A CG  1 
ATOM   1781 O OD1 A ASP A 1 229 ? 15.99204  8.47805  0.69286   0.500 26.97466 ? 229 ASP A OD1 1 
ATOM   1782 O OD1 B ASP A 1 229 ? 14.39345  11.52806 1.04694   0.500 33.81408 ? 229 ASP A OD1 1 
ATOM   1783 O OD2 A ASP A 1 229 ? 17.83819  9.64791  0.88961   0.500 23.59779 ? 229 ASP A OD2 1 
ATOM   1784 O OD2 B ASP A 1 229 ? 16.47142  11.98082 1.56673   0.500 45.86239 ? 229 ASP A OD2 1 
ATOM   1785 N N   . PHE A 1 230 ? 14.43900  11.83247 -2.90852  1.000 17.58727 ? 230 PHE A N   1 
ATOM   1786 C CA  . PHE A 1 230 ? 13.56795  12.84338 -3.49778  1.000 15.92751 ? 230 PHE A CA  1 
ATOM   1787 C C   . PHE A 1 230 ? 12.21252  12.24182 -3.84475  1.000 14.86217 ? 230 PHE A C   1 
ATOM   1788 O O   . PHE A 1 230 ? 11.16226  12.83566 -3.57353  1.000 17.37845 ? 230 PHE A O   1 
ATOM   1789 C CB  . PHE A 1 230 ? 14.18876  13.46683 -4.74807  1.000 15.42465 ? 230 PHE A CB  1 
ATOM   1790 C CG  . PHE A 1 230 ? 13.22976  14.36705 -5.47904  1.000 16.29382 ? 230 PHE A CG  1 
ATOM   1791 C CD1 . PHE A 1 230 ? 12.97055  15.64793 -5.01087  1.000 14.16036 ? 230 PHE A CD1 1 
ATOM   1792 C CD2 . PHE A 1 230 ? 12.56010  13.91830 -6.60214  1.000 13.12006 ? 230 PHE A CD2 1 
ATOM   1793 C CE1 . PHE A 1 230 ? 12.06969  16.46910 -5.65388  1.000 14.93769 ? 230 PHE A CE1 1 
ATOM   1794 C CE2 . PHE A 1 230 ? 11.64968  14.73901 -7.25328  1.000 15.84153 ? 230 PHE A CE2 1 
ATOM   1795 C CZ  . PHE A 1 230 ? 11.41662  16.01856 -6.78242  1.000 17.23840 ? 230 PHE A CZ  1 
ATOM   1796 N N   . ASN A 1 231 ? 12.21590  11.06809 -4.47256  1.000 15.02527 ? 231 ASN A N   1 
ATOM   1797 C CA  . ASN A 1 231 ? 10.95152  10.50647 -4.93082  1.000 14.39719 ? 231 ASN A CA  1 
ATOM   1798 C C   . ASN A 1 231 ? 10.04266  10.12217 -3.76519  1.000 17.54005 ? 231 ASN A C   1 
ATOM   1799 O O   . ASN A 1 231 ? 8.81586   10.15852 -3.90511  1.000 18.78829 ? 231 ASN A O   1 
ATOM   1800 C CB  . ASN A 1 231 ? 11.22013  9.32555  -5.85734  1.000 13.95151 ? 231 ASN A CB  1 
ATOM   1801 C CG  . ASN A 1 231 ? 11.56651  9.77577  -7.26352  1.000 14.31790 ? 231 ASN A CG  1 
ATOM   1802 O OD1 . ASN A 1 231 ? 11.08119  10.81436 -7.72252  1.000 16.00669 ? 231 ASN A OD1 1 
ATOM   1803 N ND2 . ASN A 1 231 ? 12.39267  8.99643  -7.95917  1.000 20.34000 ? 231 ASN A ND2 1 
ATOM   1804 N N   . LEU A 1 232 ? 10.60856  9.77479  -2.60929  1.000 19.91811 ? 232 LEU A N   1 
ATOM   1805 C CA  . LEU A 1 232 ? 9.76804   9.52380  -1.43847  1.000 20.13967 ? 232 LEU A CA  1 
ATOM   1806 C C   . LEU A 1 232 ? 9.04472   10.78973 -1.00159  1.000 22.82480 ? 232 LEU A C   1 
ATOM   1807 O O   . LEU A 1 232 ? 7.85745   10.75218 -0.65446  1.000 23.25675 ? 232 LEU A O   1 
ATOM   1808 C CB  . LEU A 1 232 ? 10.60729  8.97120  -0.28758  1.000 24.51721 ? 232 LEU A CB  1 
ATOM   1809 C CG  . LEU A 1 232 ? 11.19129  7.57147  -0.44863  1.000 24.81947 ? 232 LEU A CG  1 
ATOM   1810 C CD1 . LEU A 1 232 ? 11.95463  7.18822  0.80174   1.000 26.98155 ? 232 LEU A CD1 1 
ATOM   1811 C CD2 . LEU A 1 232 ? 10.08984  6.56264  -0.72662  1.000 28.21002 ? 232 LEU A CD2 1 
ATOM   1812 N N   . VAL A 1 233 ? 9.74590   11.92302 -1.00739  1.000 26.87982 ? 233 VAL A N   1 
ATOM   1813 C CA  . VAL A 1 233 ? 9.12869   13.18501 -0.61239  1.000 31.11701 ? 233 VAL A CA  1 
ATOM   1814 C C   . VAL A 1 233 ? 8.10958   13.63071 -1.65263  1.000 32.79923 ? 233 VAL A C   1 
ATOM   1815 O O   . VAL A 1 233 ? 6.97512   13.99637 -1.31979  1.000 36.49060 ? 233 VAL A O   1 
ATOM   1816 C CB  . VAL A 1 233 ? 10.21272  14.25408 -0.38613  1.000 32.33088 ? 233 VAL A CB  1 
ATOM   1817 C CG1 . VAL A 1 233 ? 9.58325   15.58618 0.00438   1.000 33.55108 ? 233 VAL A CG1 1 
ATOM   1818 C CG2 . VAL A 1 233 ? 11.18573  13.78366 0.67016   1.000 28.18085 ? 233 VAL A CG2 1 
ATOM   1819 N N   . ALA A 1 234 ? 8.49821   13.61307 -2.92874  1.000 22.01482 ? 234 ALA A N   1 
ATOM   1820 C CA  . ALA A 1 234 ? 7.59042   14.05469 -3.98073  1.000 29.89756 ? 234 ALA A CA  1 
ATOM   1821 C C   . ALA A 1 234 ? 6.28068   13.27601 -3.94627  1.000 28.21184 ? 234 ALA A C   1 
ATOM   1822 O O   . ALA A 1 234 ? 5.20458   13.84605 -4.16767  1.000 26.09420 ? 234 ALA A O   1 
ATOM   1823 C CB  . ALA A 1 234 ? 8.25985   13.91773 -5.34755  1.000 30.22940 ? 234 ALA A CB  1 
ATOM   1824 N N   . MET A 1 235 ? 6.34636   11.97334 -3.66191  1.000 24.95977 ? 235 MET A N   1 
ATOM   1825 C CA  . MET A 1 235 ? 5.13811   11.15463 -3.71329  1.000 22.83827 ? 235 MET A CA  1 
ATOM   1826 C C   . MET A 1 235 ? 4.04410   11.72281 -2.81778  1.000 18.47904 ? 235 MET A C   1 
ATOM   1827 O O   . MET A 1 235 ? 2.88086   11.82104 -3.22459  1.000 17.70057 ? 235 MET A O   1 
ATOM   1828 C CB  . MET A 1 235 ? 5.45299   9.71291  -3.32071  1.000 21.29822 ? 235 MET A CB  1 
ATOM   1829 C CG  . MET A 1 235 ? 4.20869   8.85059  -3.21400  1.000 23.54804 ? 235 MET A CG  1 
ATOM   1830 S SD  . MET A 1 235 ? 4.58477   7.12713  -2.89217  1.000 34.03421 ? 235 MET A SD  1 
ATOM   1831 C CE  . MET A 1 235 ? 6.28273   7.26377  -2.33039  1.000 44.35099 ? 235 MET A CE  1 
ATOM   1832 N N   . LYS A 1 236 ? 4.39406   12.09607 -1.58740  1.000 14.76788 ? 236 LYS A N   1 
ATOM   1833 C CA  . LYS A 1 236 ? 3.38530   12.60653 -0.66674  1.000 15.51770 ? 236 LYS A CA  1 
ATOM   1834 C C   . LYS A 1 236 ? 2.70106   13.85774 -1.20138  1.000 19.95660 ? 236 LYS A C   1 
ATOM   1835 O O   . LYS A 1 236 ? 1.53379   14.11676 -0.87850  1.000 17.39481 ? 236 LYS A O   1 
ATOM   1836 C CB  . LYS A 1 236 ? 4.01065   12.90161 0.70039   1.000 22.00250 ? 236 LYS A CB  1 
ATOM   1837 C CG  . LYS A 1 236 ? 3.24371   13.95595 1.47172   1.000 39.77578 ? 236 LYS A CG  1 
ATOM   1838 C CD  . LYS A 1 236 ? 3.43191   13.83346 2.97595   1.000 45.16451 ? 236 LYS A CD  1 
ATOM   1839 C CE  . LYS A 1 236 ? 4.84716   14.15916 3.38404   1.000 33.44936 ? 236 LYS A CE  1 
ATOM   1840 N NZ  . LYS A 1 236 ? 4.88888   14.72980 4.76167   1.000 48.15747 ? 236 LYS A NZ  1 
ATOM   1841 N N   . TYR A 1 237 ? 3.39934   14.65153 -2.01189  1.000 20.00538 ? 237 TYR A N   1 
ATOM   1842 C CA  . TYR A 1 237 ? 2.84641   15.90455 -2.49764  1.000 15.42477 ? 237 TYR A CA  1 
ATOM   1843 C C   . TYR A 1 237 ? 2.20727   15.76390 -3.87520  1.000 16.57251 ? 237 TYR A C   1 
ATOM   1844 O O   . TYR A 1 237 ? 1.94462   16.76986 -4.53892  1.000 17.34378 ? 237 TYR A O   1 
ATOM   1845 C CB  . TYR A 1 237 ? 3.92776   16.98533 -2.47925  1.000 19.35828 ? 237 TYR A CB  1 
ATOM   1846 C CG  . TYR A 1 237 ? 4.35730   17.29243 -1.06675  1.000 14.31469 ? 237 TYR A CG  1 
ATOM   1847 C CD1 . TYR A 1 237 ? 3.58231   18.10992 -0.24998  1.000 16.24050 ? 237 TYR A CD1 1 
ATOM   1848 C CD2 . TYR A 1 237 ? 5.52054   16.74345 -0.53590  1.000 17.04389 ? 237 TYR A CD2 1 
ATOM   1849 C CE1 . TYR A 1 237 ? 3.95890   18.38360 1.05161   1.000 22.07326 ? 237 TYR A CE1 1 
ATOM   1850 C CE2 . TYR A 1 237 ? 5.90546   17.01555 0.76456   1.000 17.60649 ? 237 TYR A CE2 1 
ATOM   1851 C CZ  . TYR A 1 237 ? 5.11431   17.83469 1.55341   1.000 23.82258 ? 237 TYR A CZ  1 
ATOM   1852 O OH  . TYR A 1 237 ? 5.49122   18.10714 2.85553   1.000 27.29432 ? 237 TYR A OH  1 
ATOM   1853 N N   . ASN A 1 238 ? 1.91711   14.53254 -4.29451  1.000 16.12812 ? 238 ASN A N   1 
ATOM   1854 C CA  . ASN A 1 238 ? 1.24238   14.26959 -5.56374  1.000 11.77480 ? 238 ASN A CA  1 
ATOM   1855 C C   . ASN A 1 238 ? 2.07435   14.77862 -6.73771  1.000 15.77521 ? 238 ASN A C   1 
ATOM   1856 O O   . ASN A 1 238 ? 1.55455   15.37447 -7.68564  1.000 15.75143 ? 238 ASN A O   1 
ATOM   1857 C CB  . ASN A 1 238 ? -0.16275  14.86730 -5.58259  1.000 16.50725 ? 238 ASN A CB  1 
ATOM   1858 C CG  . ASN A 1 238 ? -1.03604  14.24299 -6.65060  1.000 15.53990 ? 238 ASN A CG  1 
ATOM   1859 O OD1 . ASN A 1 238 ? -0.82824  13.09172 -7.03464  1.000 19.61773 ? 238 ASN A OD1 1 
ATOM   1860 N ND2 . ASN A 1 238 ? -1.99601  15.00259 -7.15365  1.000 20.22936 ? 238 ASN A ND2 1 
ATOM   1861 N N   . TYR A 1 239 ? 3.38162   14.55780 -6.65178  1.000 13.47733 ? 239 TYR A N   1 
ATOM   1862 C CA  . TYR A 1 239 ? 4.31034   14.73710 -7.75994  1.000 13.70920 ? 239 TYR A CA  1 
ATOM   1863 C C   . TYR A 1 239 ? 4.60824   13.36806 -8.35484  1.000 18.36934 ? 239 TYR A C   1 
ATOM   1864 O O   . TYR A 1 239 ? 4.67238   12.37296 -7.62791  1.000 18.67378 ? 239 TYR A O   1 
ATOM   1865 C CB  . TYR A 1 239 ? 5.60601   15.40405 -7.28362  1.000 13.08410 ? 239 TYR A CB  1 
ATOM   1866 C CG  . TYR A 1 239 ? 5.57938   16.91663 -7.30009  1.000 13.89230 ? 239 TYR A CG  1 
ATOM   1867 C CD1 . TYR A 1 239 ? 4.62446   17.63047 -6.57890  1.000 14.88191 ? 239 TYR A CD1 1 
ATOM   1868 C CD2 . TYR A 1 239 ? 6.53004   17.63229 -8.02153  1.000 14.18079 ? 239 TYR A CD2 1 
ATOM   1869 C CE1 . TYR A 1 239 ? 4.60583   19.01602 -6.59402  1.000 16.58065 ? 239 TYR A CE1 1 
ATOM   1870 C CE2 . TYR A 1 239 ? 6.52180   19.01232 -8.04058  1.000 15.05717 ? 239 TYR A CE2 1 
ATOM   1871 C CZ  . TYR A 1 239 ? 5.55658   19.69721 -7.33051  1.000 16.55953 ? 239 TYR A CZ  1 
ATOM   1872 O OH  . TYR A 1 239 ? 5.55166   21.07039 -7.35489  1.000 20.76168 ? 239 TYR A OH  1 
ATOM   1873 N N   . GLU A 1 240 ? 4.75984   13.30326 -9.67640  1.000 14.25191 ? 240 GLU A N   1 
ATOM   1874 C CA  . GLU A 1 240 ? 5.07042   12.02280 -10.29279 1.000 14.87603 ? 240 GLU A CA  1 
ATOM   1875 C C   . GLU A 1 240 ? 6.51960   11.63506 -10.00478 1.000 15.51759 ? 240 GLU A C   1 
ATOM   1876 O O   . GLU A 1 240 ? 7.36609   12.48765 -9.71699  1.000 14.98287 ? 240 GLU A O   1 
ATOM   1877 C CB  . GLU A 1 240 ? 4.80340   12.06332 -11.79636 1.000 21.14849 ? 240 GLU A CB  1 
ATOM   1878 C CG  . GLU A 1 240 ? 5.73800   12.94765 -12.59775 1.000 25.89660 ? 240 GLU A CG  1 
ATOM   1879 C CD  . GLU A 1 240 ? 5.35375   12.99464 -14.06790 1.000 28.92780 ? 240 GLU A CD  1 
ATOM   1880 O OE1 . GLU A 1 240 ? 4.22398   12.57155 -14.38464 1.000 30.26864 ? 240 GLU A OE1 1 
ATOM   1881 O OE2 . GLU A 1 240 ? 6.17693   13.44445 -14.90119 1.000 29.22282 ? 240 GLU A OE2 1 
ATOM   1882 N N   . PRO A 1 241 ? 6.82758   10.34469 -10.04151 1.000 15.34692 ? 241 PRO A N   1 
ATOM   1883 C CA  . PRO A 1 241 ? 8.21328   9.93058  -9.81212  1.000 18.65659 ? 241 PRO A CA  1 
ATOM   1884 C C   . PRO A 1 241 ? 9.13509   10.53050 -10.86209 1.000 18.61079 ? 241 PRO A C   1 
ATOM   1885 O O   . PRO A 1 241 ? 8.80367   10.59328 -12.04780 1.000 19.02938 ? 241 PRO A O   1 
ATOM   1886 C CB  . PRO A 1 241 ? 8.15343   8.40207  -9.91921  1.000 21.68861 ? 241 PRO A CB  1 
ATOM   1887 C CG  . PRO A 1 241 ? 6.71166   8.06595  -9.64850  1.000 18.39207 ? 241 PRO A CG  1 
ATOM   1888 C CD  . PRO A 1 241 ? 5.92464   9.19376  -10.21733 1.000 17.49553 ? 241 PRO A CD  1 
ATOM   1889 N N   . LEU A 1 242 ? 10.30145  10.97318 -10.41535 1.000 14.13040 ? 242 LEU A N   1 
ATOM   1890 C CA  . LEU A 1 242 ? 11.33559  11.44232 -11.32528 1.000 14.49268 ? 242 LEU A CA  1 
ATOM   1891 C C   . LEU A 1 242 ? 12.19704  10.25304 -11.73281 1.000 16.87806 ? 242 LEU A C   1 
ATOM   1892 O O   . LEU A 1 242 ? 12.76101  9.56550  -10.87783 1.000 18.42659 ? 242 LEU A O   1 
ATOM   1893 C CB  . LEU A 1 242 ? 12.17748  12.53126 -10.66626 1.000 15.62045 ? 242 LEU A CB  1 
ATOM   1894 C CG  . LEU A 1 242 ? 13.20091  13.23280 -11.55455 1.000 15.19862 ? 242 LEU A CG  1 
ATOM   1895 C CD1 . LEU A 1 242 ? 12.50777  14.09604 -12.59869 1.000 16.30497 ? 242 LEU A CD1 1 
ATOM   1896 C CD2 . LEU A 1 242 ? 14.10422  14.07033 -10.69035 1.000 14.74132 ? 242 LEU A CD2 1 
ATOM   1897 N N   . THR A 1 243 ? 12.26834  9.99470  -13.03279 1.000 14.23081 ? 243 THR A N   1 
ATOM   1898 C CA  . THR A 1 243 ? 12.99382  8.85629  -13.57198 1.000 14.54848 ? 243 THR A CA  1 
ATOM   1899 C C   . THR A 1 243 ? 14.36782  9.29622  -14.06137 1.000 15.61986 ? 243 THR A C   1 
ATOM   1900 O O   . THR A 1 243 ? 14.64283  10.48551 -14.23316 1.000 15.92486 ? 243 THR A O   1 
ATOM   1901 C CB  . THR A 1 243 ? 12.21953  8.22607  -14.72789 1.000 14.63296 ? 243 THR A CB  1 
ATOM   1902 O OG1 . THR A 1 243 ? 12.18207  9.15660  -15.81855 1.000 14.32137 ? 243 THR A OG1 1 
ATOM   1903 C CG2 . THR A 1 243 ? 10.79509  7.87975  -14.31813 1.000 18.90764 ? 243 THR A CG2 1 
ATOM   1904 N N   . GLN A 1 244 ? 15.23890  8.31296  -14.30682 1.000 14.82799 ? 244 GLN A N   1 
ATOM   1905 C CA  . GLN A 1 244 ? 16.54481  8.64651  -14.86497 1.000 17.88198 ? 244 GLN A CA  1 
ATOM   1906 C C   . GLN A 1 244 ? 16.40809  9.25528  -16.25275 1.000 15.81155 ? 244 GLN A C   1 
ATOM   1907 O O   . GLN A 1 244 ? 17.21047  10.11506 -16.63163 1.000 15.86069 ? 244 GLN A O   1 
ATOM   1908 C CB  . GLN A 1 244 ? 17.44429  7.41099  -14.91070 1.000 16.97343 ? 244 GLN A CB  1 
ATOM   1909 C CG  . GLN A 1 244 ? 18.86956  7.70921  -15.36396 1.000 14.88592 ? 244 GLN A CG  1 
ATOM   1910 C CD  . GLN A 1 244 ? 19.57143  8.69843  -14.45805 1.000 18.42065 ? 244 GLN A CD  1 
ATOM   1911 O OE1 . GLN A 1 244 ? 19.53999  8.57060  -13.23389 1.000 20.05221 ? 244 GLN A OE1 1 
ATOM   1912 N NE2 . GLN A 1 244 ? 20.20952  9.69727  -15.05705 1.000 18.10262 ? 244 GLN A NE2 1 
ATOM   1913 N N   . ASP A 1 245 ? 15.40386  8.83114  -17.02521 1.000 15.18233 ? 245 ASP A N   1 
ATOM   1914 C CA  . ASP A 1 245 ? 15.15707  9.48063  -18.30815 1.000 18.45608 ? 245 ASP A CA  1 
ATOM   1915 C C   . ASP A 1 245 ? 14.87601  10.96426 -18.11108 1.000 14.84412 ? 245 ASP A C   1 
ATOM   1916 O O   . ASP A 1 245 ? 15.34450  11.80483 -18.88682 1.000 16.54194 ? 245 ASP A O   1 
ATOM   1917 C CB  . ASP A 1 245 ? 13.98169  8.82140  -19.03443 1.000 18.01915 ? 245 ASP A CB  1 
ATOM   1918 C CG  . ASP A 1 245 ? 14.35548  7.51555  -19.71998 1.000 24.41376 ? 245 ASP A CG  1 
ATOM   1919 O OD1 . ASP A 1 245 ? 15.54288  7.12272  -19.70627 1.000 24.38274 ? 245 ASP A OD1 1 
ATOM   1920 O OD2 . ASP A 1 245 ? 13.43917  6.87723  -20.28065 1.000 27.97997 ? 245 ASP A OD2 1 
ATOM   1921 N N   . HIS A 1 246 ? 14.07997  11.29998 -17.09321 1.000 16.95467 ? 246 HIS A N   1 
ATOM   1922 C CA  . HIS A 1 246 ? 13.80076  12.70129 -16.79904 1.000 15.88808 ? 246 HIS A CA  1 
ATOM   1923 C C   . HIS A 1 246 ? 15.07367  13.43665 -16.41327 1.000 14.16976 ? 246 HIS A C   1 
ATOM   1924 O O   . HIS A 1 246 ? 15.31423  14.56726 -16.86037 1.000 14.09294 ? 246 HIS A O   1 
ATOM   1925 C CB  . HIS A 1 246 ? 12.77188  12.81089 -15.67597 1.000 16.41827 ? 246 HIS A CB  1 
ATOM   1926 C CG  . HIS A 1 246 ? 11.42390  12.28453 -16.04239 1.000 22.11946 ? 246 HIS A CG  1 
ATOM   1927 N ND1 . HIS A 1 246 ? 10.52303  11.82540 -15.10591 1.000 22.57567 ? 246 HIS A ND1 1 
ATOM   1928 C CD2 . HIS A 1 246 ? 10.82248  12.14176 -17.24601 1.000 19.78133 ? 246 HIS A CD2 1 
ATOM   1929 C CE1 . HIS A 1 246 ? 9.42145   11.42683 -15.71675 1.000 27.02671 ? 246 HIS A CE1 1 
ATOM   1930 N NE2 . HIS A 1 246 ? 9.57370   11.61666 -17.01466 1.000 19.41899 ? 246 HIS A NE2 1 
ATOM   1931 N N   . VAL A 1 247 ? 15.88407  12.82775 -15.54209 1.000 13.71623 ? 247 VAL A N   1 
ATOM   1932 C CA  . VAL A 1 247 ? 17.17402  13.42669 -15.20244 1.000 13.79330 ? 247 VAL A CA  1 
ATOM   1933 C C   . VAL A 1 247 ? 17.97510  13.70435 -16.46708 1.000 14.12521 ? 247 VAL A C   1 
ATOM   1934 O O   . VAL A 1 247 ? 18.55719  14.78363 -16.63019 1.000 16.99216 ? 247 VAL A O   1 
ATOM   1935 C CB  . VAL A 1 247 ? 17.94920  12.52002 -14.23034 1.000 16.12783 ? 247 VAL A CB  1 
ATOM   1936 C CG1 . VAL A 1 247 ? 19.33274  13.09538 -13.97753 1.000 16.49204 ? 247 VAL A CG1 1 
ATOM   1937 C CG2 . VAL A 1 247 ? 17.18363  12.38394 -12.92543 1.000 15.75337 ? 247 VAL A CG2 1 
ATOM   1938 N N   . ASP A 1 248 ? 18.00451  12.74086 -17.39340 1.000 15.21164 ? 248 ASP A N   1 
ATOM   1939 C CA  . ASP A 1 248 ? 18.81052  12.90222 -18.60120 1.000 12.59256 ? 248 ASP A CA  1 
ATOM   1940 C C   . ASP A 1 248 ? 18.30485  14.04735 -19.46880 1.000 11.94491 ? 248 ASP A C   1 
ATOM   1941 O O   . ASP A 1 248 ? 19.10900  14.79705 -20.03434 1.000 16.24464 ? 248 ASP A O   1 
ATOM   1942 C CB  . ASP A 1 248 ? 18.84472  11.59590 -19.39486 1.000 14.60235 ? 248 ASP A CB  1 
ATOM   1943 C CG  . ASP A 1 248 ? 19.64648  10.49673 -18.68944 1.000 18.67001 ? 248 ASP A CG  1 
ATOM   1944 O OD1 . ASP A 1 248 ? 20.37120  10.79094 -17.71276 1.000 17.06153 ? 248 ASP A OD1 1 
ATOM   1945 O OD2 . ASP A 1 248 ? 19.55292  9.32965  -19.12501 1.000 21.64069 ? 248 ASP A OD2 1 
ATOM   1946 N N   . ILE A 1 249 ? 16.98229  14.22112 -19.58075 1.000 14.01168 ? 249 ILE A N   1 
ATOM   1947 C CA  . ILE A 1 249 ? 16.50585  15.30465 -20.43590 1.000 13.07108 ? 249 ILE A CA  1 
ATOM   1948 C C   . ILE A 1 249 ? 16.74326  16.66210 -19.78512 1.000 13.96174 ? 249 ILE A C   1 
ATOM   1949 O O   . ILE A 1 249 ? 16.73611  17.68632 -20.48112 1.000 13.73569 ? 249 ILE A O   1 
ATOM   1950 C CB  . ILE A 1 249 ? 15.02730  15.13787 -20.84845 1.000 16.60661 ? 249 ILE A CB  1 
ATOM   1951 C CG1 . ILE A 1 249 ? 14.08287  15.24348 -19.65445 1.000 16.24645 ? 249 ILE A CG1 1 
ATOM   1952 C CG2 . ILE A 1 249 ? 14.83074  13.82573 -21.57943 1.000 20.25097 ? 249 ILE A CG2 1 
ATOM   1953 C CD1 . ILE A 1 249 ? 12.62570  15.35592 -20.07409 1.000 22.26293 ? 249 ILE A CD1 1 
ATOM   1954 N N   . LEU A 1 250 ? 16.99686  16.69930 -18.47544 1.000 13.97633 ? 250 LEU A N   1 
ATOM   1955 C CA  . LEU A 1 250 ? 17.34979  17.95093 -17.81799 1.000 12.37332 ? 250 LEU A CA  1 
ATOM   1956 C C   . LEU A 1 250 ? 18.81959  18.30086 -17.99126 1.000 12.59256 ? 250 LEU A C   1 
ATOM   1957 O O   . LEU A 1 250 ? 19.25036  19.37047 -17.54020 1.000 13.78878 ? 250 LEU A O   1 
ATOM   1958 C CB  . LEU A 1 250 ? 16.99195  17.88243 -16.32298 1.000 13.39541 ? 250 LEU A CB  1 
ATOM   1959 C CG  . LEU A 1 250 ? 15.49907  18.07832 -16.02188 1.000 13.03452 ? 250 LEU A CG  1 
ATOM   1960 C CD1 . LEU A 1 250 ? 15.15515  17.58671 -14.61041 1.000 10.12266 ? 250 LEU A CD1 1 
ATOM   1961 C CD2 . LEU A 1 250 ? 15.09785  19.54917 -16.19843 1.000 10.39787 ? 250 LEU A CD2 1 
ATOM   1962 N N   . GLY A 1 251 ? 19.58575  17.43301 -18.64806 1.000 11.63479 ? 251 GLY A N   1 
ATOM   1963 C CA  . GLY A 1 251 ? 21.01725  17.59257 -18.76703 1.000 13.20021 ? 251 GLY A CA  1 
ATOM   1964 C C   . GLY A 1 251 ? 21.46517  18.92306 -19.33678 1.000 13.18342 ? 251 GLY A C   1 
ATOM   1965 O O   . GLY A 1 251 ? 22.35358  19.58008 -18.78787 1.000 13.37276 ? 251 GLY A O   1 
ATOM   1966 N N   . PRO A 1 252 ? 20.89133  19.34015 -20.46880 1.000 11.33118 ? 252 PRO A N   1 
ATOM   1967 C CA  . PRO A 1 252 ? 21.33531  20.61555 -21.05455 1.000 11.77171 ? 252 PRO A CA  1 
ATOM   1968 C C   . PRO A 1 252 ? 21.16117  21.79873 -20.12014 1.000 12.22461 ? 252 PRO A C   1 
ATOM   1969 O O   . PRO A 1 252 ? 22.06929  22.63433 -20.01617 1.000 13.06256 ? 252 PRO A O   1 
ATOM   1970 C CB  . PRO A 1 252 ? 20.46514  20.73680 -22.30810 1.000 11.51504 ? 252 PRO A CB  1 
ATOM   1971 C CG  . PRO A 1 252 ? 20.24638  19.30882 -22.72047 1.000 13.03272 ? 252 PRO A CG  1 
ATOM   1972 C CD  . PRO A 1 252 ? 20.06797  18.55886 -21.41465 1.000 12.61364 ? 252 PRO A CD  1 
ATOM   1973 N N   . LEU A 1 253 ? 20.01907  21.89442 -19.42634 1.000 12.64770 ? 253 LEU A N   1 
ATOM   1974 C CA  . LEU A 1 253 ? 19.82727  22.98498 -18.46942 1.000 10.69447 ? 253 LEU A CA  1 
ATOM   1975 C C   . LEU A 1 253 ? 20.79043  22.86897 -17.29066 1.000 12.43209 ? 253 LEU A C   1 
ATOM   1976 O O   . LEU A 1 253 ? 21.31052  23.88008 -16.79243 1.000 12.95100 ? 253 LEU A O   1 
ATOM   1977 C CB  . LEU A 1 253 ? 18.37218  23.00042 -17.98449 1.000 11.19283 ? 253 LEU A CB  1 
ATOM   1978 C CG  . LEU A 1 253 ? 17.39077  23.42360 -19.07946 1.000 11.19649 ? 253 LEU A CG  1 
ATOM   1979 C CD1 . LEU A 1 253 ? 15.94211  23.15496 -18.68045 1.000 12.12534 ? 253 LEU A CD1 1 
ATOM   1980 C CD2 . LEU A 1 253 ? 17.57017  24.89727 -19.40929 1.000 12.56511 ? 253 LEU A CD2 1 
ATOM   1981 N N   . SER A 1 254 ? 21.03494  21.64591 -16.82596 1.000 13.15005 ? 254 SER A N   1 
ATOM   1982 C CA  . SER A 1 254 ? 21.97297  21.44797 -15.73161 1.000 11.83365 ? 254 SER A CA  1 
ATOM   1983 C C   . SER A 1 254 ? 23.38462  21.85707 -16.13992 1.000 13.26461 ? 254 SER A C   1 
ATOM   1984 O O   . SER A 1 254 ? 24.10167  22.50269 -15.36593 1.000 13.95035 ? 254 SER A O   1 
ATOM   1985 C CB  . SER A 1 254 ? 21.92449  19.98771 -15.27968 1.000 13.84964 ? 254 SER A CB  1 
ATOM   1986 O OG  . SER A 1 254 ? 22.91763  19.71372 -14.30717 1.000 13.23274 ? 254 SER A OG  1 
ATOM   1987 N N   . ALA A 1 255 ? 23.79980  21.49909 -17.35744 1.000 12.39776 ? 255 ALA A N   1 
ATOM   1988 C CA  . ALA A 1 255 ? 25.13370  21.87462 -17.82129 1.000 13.51937 ? 255 ALA A CA  1 
ATOM   1989 C C   . ALA A 1 255 ? 25.24873  23.37983 -18.02761 1.000 16.84488 ? 255 ALA A C   1 
ATOM   1990 O O   . ALA A 1 255 ? 26.29735  23.97156 -17.74909 1.000 16.04388 ? 255 ALA A O   1 
ATOM   1991 C CB  . ALA A 1 255 ? 25.46484  21.13582 -19.11676 1.000 14.61385 ? 255 ALA A CB  1 
ATOM   1992 N N   . GLN A 1 256 ? 24.18759  24.01844 -18.52062 1.000 14.27300 ? 256 GLN A N   1 
ATOM   1993 C CA  . GLN A 1 256 ? 24.25108  25.45759 -18.76040 1.000 16.49814 ? 256 GLN A CA  1 
ATOM   1994 C C   . GLN A 1 256 ? 24.41360  26.23611 -17.46012 1.000 15.05105 ? 256 GLN A C   1 
ATOM   1995 O O   . GLN A 1 256 ? 25.20611  27.18388 -17.39019 1.000 19.84773 ? 256 GLN A O   1 
ATOM   1996 C CB  . GLN A 1 256 ? 22.99795  25.92493 -19.49875 1.000 18.65757 ? 256 GLN A CB  1 
ATOM   1997 C CG  . GLN A 1 256 ? 22.88502  27.43427 -19.59012 1.000 17.22795 ? 256 GLN A CG  1 
ATOM   1998 C CD  . GLN A 1 256 ? 21.63838  27.89109 -20.32137 1.000 26.72363 ? 256 GLN A CD  1 
ATOM   1999 O OE1 . GLN A 1 256 ? 20.91642  27.08179 -20.91452 1.000 28.06606 ? 256 GLN A OE1 1 
ATOM   2000 N NE2 . GLN A 1 256 ? 21.37441  29.19780 -20.28257 1.000 24.09750 ? 256 GLN A NE2 1 
ATOM   2001 N N   . THR A 1 257 ? 23.67101  25.85401 -16.42237 1.000 14.50351 ? 257 THR A N   1 
ATOM   2002 C CA  . THR A 1 257 ? 23.66582  26.57664 -15.15932 1.000 13.60713 ? 257 THR A CA  1 
ATOM   2003 C C   . THR A 1 257 ? 24.68040  26.04908 -14.16423 1.000 15.22448 ? 257 THR A C   1 
ATOM   2004 O O   . THR A 1 257 ? 24.92033  26.70627 -13.15143 1.000 14.51998 ? 257 THR A O   1 
ATOM   2005 C CB  . THR A 1 257 ? 22.27721  26.50876 -14.51120 1.000 14.04566 ? 257 THR A CB  1 
ATOM   2006 O OG1 . THR A 1 257 ? 21.93586  25.13752 -14.25622 1.000 11.87529 ? 257 THR A OG1 1 
ATOM   2007 C CG2 . THR A 1 257 ? 21.23391  27.13751 -15.42967 1.000 14.53182 ? 257 THR A CG2 1 
ATOM   2008 N N   . GLY A 1 258 ? 25.24794  24.87023 -14.40130 1.000 12.53999 ? 258 GLY A N   1 
ATOM   2009 C CA  . GLY A 1 258 ? 26.13177  24.28855 -13.41839 1.000 12.08757 ? 258 GLY A CA  1 
ATOM   2010 C C   . GLY A 1 258 ? 25.45569  23.75557 -12.18014 1.000 17.87117 ? 258 GLY A C   1 
ATOM   2011 O O   . GLY A 1 258 ? 26.14192  23.47053 -11.19498 1.000 19.60732 ? 258 GLY A O   1 
ATOM   2012 N N   . ILE A 1 259 ? 24.13305  23.62477 -12.18222 1.000 12.95647 ? 259 ILE A N   1 
ATOM   2013 C CA  . ILE A 1 259 ? 23.40607  23.08503 -11.04046 1.000 14.34517 ? 259 ILE A CA  1 
ATOM   2014 C C   . ILE A 1 259 ? 23.06602  21.63418 -11.34925 1.000 13.86690 ? 259 ILE A C   1 
ATOM   2015 O O   . ILE A 1 259 ? 22.26249  21.35274 -12.24450 1.000 14.34153 ? 259 ILE A O   1 
ATOM   2016 C CB  . ILE A 1 259 ? 22.14351  23.90087 -10.73679 1.000 14.42464 ? 259 ILE A CB  1 
ATOM   2017 C CG1 . ILE A 1 259 ? 22.51281  25.35020 -10.41319 1.000 12.15963 ? 259 ILE A CG1 1 
ATOM   2018 C CG2 . ILE A 1 259 ? 21.38971  23.28336 -9.57675  1.000 12.27294 ? 259 ILE A CG2 1 
ATOM   2019 C CD1 . ILE A 1 259 ? 21.31929  26.29646 -10.38227 1.000 17.18938 ? 259 ILE A CD1 1 
ATOM   2020 N N   . ALA A 1 260 ? 23.66789  20.70826 -10.60255 1.000 13.83423 ? 260 ALA A N   1 
ATOM   2021 C CA  . ALA A 1 260 ? 23.35067  19.29621 -10.77160 1.000 10.87879 ? 260 ALA A CA  1 
ATOM   2022 C C   . ALA A 1 260 ? 21.85350  19.06648 -10.57749 1.000 14.03606 ? 260 ALA A C   1 
ATOM   2023 O O   . ALA A 1 260 ? 21.22028  19.69563 -9.72408  1.000 13.43904 ? 260 ALA A O   1 
ATOM   2024 C CB  . ALA A 1 260 ? 24.14632  18.45174 -9.77407  1.000 13.07269 ? 260 ALA A CB  1 
ATOM   2025 N N   . VAL A 1 261 ? 21.29297  18.14639 -11.36835 1.000 13.62041 ? 261 VAL A N   1 
ATOM   2026 C CA  . VAL A 1 261 ? 19.86080  17.86542 -11.28438 1.000 14.15418 ? 261 VAL A CA  1 
ATOM   2027 C C   . VAL A 1 261 ? 19.46970  17.49030 -9.86285  1.000 14.82561 ? 261 VAL A C   1 
ATOM   2028 O O   . VAL A 1 261 ? 18.46510  17.97491 -9.32907  1.000 14.28254 ? 261 VAL A O   1 
ATOM   2029 C CB  . VAL A 1 261 ? 19.45959  16.76301 -12.28098 1.000 11.64180 ? 261 VAL A CB  1 
ATOM   2030 C CG1 . VAL A 1 261 ? 18.00858  16.37084 -12.04938 1.000 13.23309 ? 261 VAL A CG1 1 
ATOM   2031 C CG2 . VAL A 1 261 ? 19.66150  17.24940 -13.71503 1.000 12.40305 ? 261 VAL A CG2 1 
ATOM   2032 N N   . LEU A 1 262 ? 20.24020  16.60572 -9.23238  1.000 14.55585 ? 262 LEU A N   1 
ATOM   2033 C CA  . LEU A 1 262 ? 19.87523  16.19372 -7.88451  1.000 12.90428 ? 262 LEU A CA  1 
ATOM   2034 C C   . LEU A 1 262 ? 20.01196  17.32561 -6.88253  1.000 12.35583 ? 262 LEU A C   1 
ATOM   2035 O O   . LEU A 1 262 ? 19.35098  17.28719 -5.84208  1.000 14.43785 ? 262 LEU A O   1 
ATOM   2036 C CB  . LEU A 1 262 ? 20.71047  14.99024 -7.44552  1.000 14.68775 ? 262 LEU A CB  1 
ATOM   2037 C CG  . LEU A 1 262 ? 20.35824  13.66274 -8.11717  1.000 16.65820 ? 262 LEU A CG  1 
ATOM   2038 C CD1 . LEU A 1 262 ? 21.28631  12.57573 -7.60632  1.000 21.60280 ? 262 LEU A CD1 1 
ATOM   2039 C CD2 . LEU A 1 262 ? 18.89929  13.28813 -7.86158  1.000 16.27375 ? 262 LEU A CD2 1 
ATOM   2040 N N   . ASP A 1 263 ? 20.86101  18.31737 -7.16523  1.000 14.97601 ? 263 ASP A N   1 
ATOM   2041 C CA  . ASP A 1 263 ? 20.89990  19.50966 -6.32855  1.000 12.49791 ? 263 ASP A CA  1 
ATOM   2042 C C   . ASP A 1 263 ? 19.62296  20.32156 -6.49101  1.000 13.79516 ? 263 ASP A C   1 
ATOM   2043 O O   . ASP A 1 263 ? 19.04010  20.77574 -5.49981  1.000 13.43871 ? 263 ASP A O   1 
ATOM   2044 C CB  . ASP A 1 263 ? 22.12759  20.35565 -6.67074  1.000 15.94641 ? 263 ASP A CB  1 
ATOM   2045 C CG  . ASP A 1 263 ? 23.44194  19.71643 -6.20915  1.000 18.05569 ? 263 ASP A CG  1 
ATOM   2046 O OD1 . ASP A 1 263 ? 23.44475  18.53299 -5.80800  1.000 17.57266 ? 263 ASP A OD1 1 
ATOM   2047 O OD2 . ASP A 1 263 ? 24.47872  20.41209 -6.24578  1.000 20.00587 ? 263 ASP A OD2 1 
ATOM   2048 N N   . MET A 1 264 ? 19.16215  20.51010 -7.73195  1.000 12.64617 ? 264 MET A N   1 
ATOM   2049 C CA  . MET A 1 264 ? 17.87481  21.17445 -7.92631  1.000 10.64677 ? 264 MET A CA  1 
ATOM   2050 C C   . MET A 1 264 ? 16.75070  20.39974 -7.25093  1.000 10.49176 ? 264 MET A C   1 
ATOM   2051 O O   . MET A 1 264 ? 15.81852  20.99721 -6.70153  1.000 13.47361 ? 264 MET A O   1 
ATOM   2052 C CB  . MET A 1 264 ? 17.57806  21.35113 -9.41628  1.000 9.80495  ? 264 MET A CB  1 
ATOM   2053 C CG  . MET A 1 264 ? 16.41222  22.31844 -9.67197  1.000 13.22340 ? 264 MET A CG  1 
ATOM   2054 S SD  . MET A 1 264 ? 16.80974  24.01104 -9.14831  1.000 12.85320 ? 264 MET A SD  1 
ATOM   2055 C CE  . MET A 1 264 ? 17.50558  24.65065 -10.67938 1.000 15.24214 ? 264 MET A CE  1 
ATOM   2056 N N   . CYS A 1 265 ? 16.81855  19.06574 -7.28415  1.000 12.03414 ? 265 CYS A N   1 
ATOM   2057 C CA  . CYS A 1 265 ? 15.82584  18.26082 -6.58038  1.000 12.22778 ? 265 CYS A CA  1 
ATOM   2058 C C   . CYS A 1 265 ? 15.82438  18.56809 -5.08873  1.000 10.88995 ? 265 CYS A C   1 
ATOM   2059 O O   . CYS A 1 265 ? 14.75859  18.65060 -4.46737  1.000 14.46937 ? 265 CYS A O   1 
ATOM   2060 C CB  . CYS A 1 265 ? 16.08616  16.77171 -6.80246  1.000 13.84346 ? 265 CYS A CB  1 
ATOM   2061 S SG  . CYS A 1 265 ? 15.66137  16.16503 -8.44107  1.000 14.75740 ? 265 CYS A SG  1 
ATOM   2062 N N   . ALA A 1 266 ? 17.00800  18.74096 -4.49391  1.000 13.77270 ? 266 ALA A N   1 
ATOM   2063 C CA  . ALA A 1 266 ? 17.06229  19.09619 -3.08100  1.000 15.07460 ? 266 ALA A CA  1 
ATOM   2064 C C   . ALA A 1 266 ? 16.37045  20.43077 -2.81986  1.000 16.44409 ? 266 ALA A C   1 
ATOM   2065 O O   . ALA A 1 266 ? 15.66717  20.58874 -1.81626  1.000 14.52105 ? 266 ALA A O   1 
ATOM   2066 C CB  . ALA A 1 266 ? 18.51259  19.13202 -2.60493  1.000 12.87968 ? 266 ALA A CB  1 
ATOM   2067 N N   . SER A 1 267 ? 16.55140  21.40378 -3.71667  1.000 14.02058 ? 267 SER A N   1 
ATOM   2068 C CA  . SER A 1 267 ? 15.86990  22.68502 -3.55527  1.000 11.03332 ? 267 SER A CA  1 
ATOM   2069 C C   . SER A 1 267 ? 14.36097  22.53779 -3.73408  1.000 12.07805 ? 267 SER A C   1 
ATOM   2070 O O   . SER A 1 267 ? 13.57856  23.13072 -2.98028  1.000 12.19076 ? 267 SER A O   1 
ATOM   2071 C CB  . SER A 1 267 ? 16.44632  23.70503 -4.53691  1.000 13.63961 ? 267 SER A CB  1 
ATOM   2072 O OG  . SER A 1 267 ? 17.77490  24.06401 -4.15781  1.000 14.20961 ? 267 SER A OG  1 
ATOM   2073 N N   . LEU A 1 268 ? 13.92885  21.75281 -4.71912  1.000 11.11317 ? 268 LEU A N   1 
ATOM   2074 C CA  . LEU A 1 268 ? 12.49534  21.53829 -4.88523  1.000 9.85652  ? 268 LEU A CA  1 
ATOM   2075 C C   . LEU A 1 268 ? 11.90369  20.84076 -3.66672  1.000 11.03801 ? 268 LEU A C   1 
ATOM   2076 O O   . LEU A 1 268 ? 10.80344  21.18239 -3.21640  1.000 13.08799 ? 268 LEU A O   1 
ATOM   2077 C CB  . LEU A 1 268 ? 12.23351  20.72727 -6.14856  1.000 14.26637 ? 268 LEU A CB  1 
ATOM   2078 C CG  . LEU A 1 268 ? 10.78884  20.28705 -6.38292  1.000 10.34125 ? 268 LEU A CG  1 
ATOM   2079 C CD1 . LEU A 1 268 ? 9.84886   21.48466 -6.35808  1.000 12.32544 ? 268 LEU A CD1 1 
ATOM   2080 C CD2 . LEU A 1 268 ? 10.69448  19.55495 -7.71390  1.000 13.34739 ? 268 LEU A CD2 1 
ATOM   2081 N N   . LYS A 1 269 ? 12.61765  19.84788 -3.12870  1.000 13.65762 ? 269 LYS A N   1 
ATOM   2082 C CA  . LYS A 1 269 ? 12.15006  19.15269 -1.93362  1.000 13.93140 ? 269 LYS A CA  1 
ATOM   2083 C C   . LYS A 1 269 ? 11.84066  20.12926 -0.81232  1.000 14.24291 ? 269 LYS A C   1 
ATOM   2084 O O   . LYS A 1 269 ? 10.81450  20.00332 -0.13155  1.000 15.59473 ? 269 LYS A O   1 
ATOM   2085 C CB  . LYS A 1 269 ? 13.19897  18.14221 -1.47047  1.000 13.34828 ? 269 LYS A CB  1 
ATOM   2086 C CG  . LYS A 1 269 ? 12.84433  17.44493 -0.16607  1.000 20.54420 ? 269 LYS A CG  1 
ATOM   2087 C CD  . LYS A 1 269 ? 14.01965  16.66847 0.41396   1.000 21.74458 ? 269 LYS A CD  1 
ATOM   2088 C CE  . LYS A 1 269 ? 14.44676  15.51378 -0.47263  1.000 27.32806 ? 269 LYS A CE  1 
ATOM   2089 N NZ  . LYS A 1 269 ? 15.51895  14.69699 0.17704   1.000 36.50568 ? 269 LYS A NZ  1 
ATOM   2090 N N   . GLU A 1 270 ? 12.72686  21.10492 -0.59908  1.000 14.47568 ? 270 GLU A N   1 
ATOM   2091 C CA  . GLU A 1 270 ? 12.50399  22.09824 0.44417   1.000 14.29205 ? 270 GLU A CA  1 
ATOM   2092 C C   . GLU A 1 270 ? 11.28326  22.96120 0.14411   1.000 14.34983 ? 270 GLU A C   1 
ATOM   2093 O O   . GLU A 1 270 ? 10.51621  23.29511 1.05652   1.000 21.76025 ? 270 GLU A O   1 
ATOM   2094 C CB  . GLU A 1 270 ? 13.74613  22.97298 0.61808   1.000 14.37233 ? 270 GLU A CB  1 
ATOM   2095 C CG  . GLU A 1 270 ? 13.55616  24.05773 1.68568   1.000 15.32130 ? 270 GLU A CG  1 
ATOM   2096 C CD  . GLU A 1 270 ? 14.83376  24.80936 2.02759   1.000 23.10102 ? 270 GLU A CD  1 
ATOM   2097 O OE1 . GLU A 1 270 ? 15.93170  24.22402 1.91836   1.000 24.16716 ? 270 GLU A OE1 1 
ATOM   2098 O OE2 . GLU A 1 270 ? 14.73728  25.99346 2.40964   1.000 27.10936 ? 270 GLU A OE2 1 
ATOM   2099 N N   . LEU A 1 271 ? 11.07873  23.33428 -1.12408  1.000 12.04663 ? 271 LEU A N   1 
ATOM   2100 C CA  . LEU A 1 271 ? 9.88345   24.10323 -1.46772  1.000 12.98606 ? 271 LEU A CA  1 
ATOM   2101 C C   . LEU A 1 271 ? 8.61516   23.32409 -1.14360  1.000 14.77755 ? 271 LEU A C   1 
ATOM   2102 O O   . LEU A 1 271 ? 7.62754   23.89760 -0.66948  1.000 17.89371 ? 271 LEU A O   1 
ATOM   2103 C CB  . LEU A 1 271 ? 9.90062   24.48854 -2.94905  1.000 12.34952 ? 271 LEU A CB  1 
ATOM   2104 C CG  . LEU A 1 271 ? 10.94971  25.52780 -3.33248  1.000 11.03659 ? 271 LEU A CG  1 
ATOM   2105 C CD1 . LEU A 1 271 ? 11.06293  25.60790 -4.85332  1.000 12.74185 ? 271 LEU A CD1 1 
ATOM   2106 C CD2 . LEU A 1 271 ? 10.62981  26.88985 -2.73676  1.000 17.78321 ? 271 LEU A CD2 1 
ATOM   2107 N N   . LEU A 1 272 ? 8.61785   22.01616 -1.40526  1.000 14.98712 ? 272 LEU A N   1 
ATOM   2108 C CA  . LEU A 1 272 ? 7.42587   21.21124 -1.15071  1.000 13.38760 ? 272 LEU A CA  1 
ATOM   2109 C C   . LEU A 1 272 ? 7.18193   21.05733 0.34426   1.000 20.99764 ? 272 LEU A C   1 
ATOM   2110 O O   . LEU A 1 272 ? 6.03555   21.11796 0.80486   1.000 19.09149 ? 272 LEU A O   1 
ATOM   2111 C CB  . LEU A 1 272 ? 7.56865   19.84108 -1.81549  1.000 16.88762 ? 272 LEU A CB  1 
ATOM   2112 C CG  . LEU A 1 272 ? 7.67255   19.83038 -3.34445  1.000 15.60675 ? 272 LEU A CG  1 
ATOM   2113 C CD1 . LEU A 1 272 ? 7.77428   18.39865 -3.86613  1.000 12.60779 ? 272 LEU A CD1 1 
ATOM   2114 C CD2 . LEU A 1 272 ? 6.47958   20.56350 -3.95932  1.000 16.07604 ? 272 LEU A CD2 1 
ATOM   2115 N N   . GLN A 1 273 ? 8.25087   20.86632 1.11908   1.000 19.82547 ? 273 GLN A N   1 
ATOM   2116 C CA  . GLN A 1 273 ? 8.10732   20.63174 2.55098   1.000 23.79141 ? 273 GLN A CA  1 
ATOM   2117 C C   . GLN A 1 273 ? 7.84820   21.91396 3.32423   1.000 20.52442 ? 273 GLN A C   1 
ATOM   2118 O O   . GLN A 1 273 ? 7.17924   21.87537 4.36448   1.000 21.78953 ? 273 GLN A O   1 
ATOM   2119 C CB  . GLN A 1 273 ? 9.35698   19.93134 3.09009   1.000 18.34030 ? 273 GLN A CB  1 
ATOM   2120 C CG  . GLN A 1 273 ? 9.52341   18.51335 2.56133   1.000 18.73927 ? 273 GLN A CG  1 
ATOM   2121 C CD  . GLN A 1 273 ? 10.81301  17.85628 3.02718   1.000 27.49168 ? 273 GLN A CD  1 
ATOM   2122 O OE1 . GLN A 1 273 ? 11.82097  18.52740 3.25575   1.000 27.39681 ? 273 GLN A OE1 1 
ATOM   2123 N NE2 . GLN A 1 273 ? 10.78498  16.53525 3.16912   1.000 29.59555 ? 273 GLN A NE2 1 
ATOM   2124 N N   . ASN A 1 274 ? 8.34808   23.05378 2.84378   1.000 18.26978 ? 274 ASN A N   1 
ATOM   2125 C CA  . ASN A 1 274 ? 8.25051   24.29516 3.59676   1.000 23.21299 ? 274 ASN A CA  1 
ATOM   2126 C C   . ASN A 1 274 ? 7.39896   25.36416 2.93422   1.000 27.47032 ? 274 ASN A C   1 
ATOM   2127 O O   . ASN A 1 274 ? 7.10851   26.37740 3.57928   1.000 25.78100 ? 274 ASN A O   1 
ATOM   2128 C CB  . ASN A 1 274 ? 9.64996   24.87141 3.86303   1.000 19.32583 ? 274 ASN A CB  1 
ATOM   2129 C CG  . ASN A 1 274 ? 10.52309  23.92208 4.65891   1.000 25.25232 ? 274 ASN A CG  1 
ATOM   2130 O OD1 . ASN A 1 274 ? 11.67550  23.68071 4.30916   1.000 54.78845 ? 274 ASN A OD1 1 
ATOM   2131 N ND2 . ASN A 1 274 ? 9.97119   23.36876 5.73057   1.000 39.14153 ? 274 ASN A ND2 1 
ATOM   2132 N N   . GLY A 1 275 ? 6.97960   25.17113 1.68689   1.000 22.63688 ? 275 GLY A N   1 
ATOM   2133 C CA  . GLY A 1 275 ? 6.24346   26.19295 0.97861   1.000 19.77965 ? 275 GLY A CA  1 
ATOM   2134 C C   . GLY A 1 275 ? 7.14328   27.31963 0.52288   1.000 20.06708 ? 275 GLY A C   1 
ATOM   2135 O O   . GLY A 1 275 ? 8.36587   27.30669 0.69593   1.000 23.12931 ? 275 GLY A O   1 
ATOM   2136 N N   . MET A 1 276 ? 6.51976   28.32597 -0.07690  1.000 21.75818 ? 276 MET A N   1 
ATOM   2137 C CA  A MET A 1 276 ? 7.25062   29.45944 -0.62580  0.500 23.01963 ? 276 MET A CA  1 
ATOM   2138 C CA  B MET A 1 276 ? 7.25184   29.45663 -0.62570  0.500 23.01669 ? 276 MET A CA  1 
ATOM   2139 C C   . MET A 1 276 ? 7.19874   30.68847 0.27083   1.000 24.38784 ? 276 MET A C   1 
ATOM   2140 O O   . MET A 1 276 ? 7.85374   31.68821 -0.03439  1.000 25.49460 ? 276 MET A O   1 
ATOM   2141 C CB  A MET A 1 276 ? 6.72071   29.80331 -2.02290  0.500 26.03082 ? 276 MET A CB  1 
ATOM   2142 C CB  B MET A 1 276 ? 6.71939   29.78005 -2.02582  0.500 26.01335 ? 276 MET A CB  1 
ATOM   2143 C CG  A MET A 1 276 ? 7.57928   29.24394 -3.16210  0.500 18.93765 ? 276 MET A CG  1 
ATOM   2144 C CG  B MET A 1 276 ? 6.88983   28.61662 -3.01025  0.500 18.84223 ? 276 MET A CG  1 
ATOM   2145 S SD  A MET A 1 276 ? 6.92040   29.61011 -4.79439  0.500 40.16110 ? 276 MET A SD  1 
ATOM   2146 S SD  B MET A 1 276 ? 6.12810   28.88447 -4.61281  0.500 39.85782 ? 276 MET A SD  1 
ATOM   2147 C CE  A MET A 1 276 ? 5.55065   28.45942 -4.83001  0.500 18.27796 ? 276 MET A CE  1 
ATOM   2148 C CE  B MET A 1 276 ? 7.12634   30.23992 -5.22147  0.500 17.86579 ? 276 MET A CE  1 
ATOM   2149 N N   . ASN A 1 277 ? 6.44653   30.63575 1.36926   1.000 39.80954 ? 277 ASN A N   1 
ATOM   2150 C CA  . ASN A 1 277 ? 6.37620   31.72164 2.34769   1.000 34.76279 ? 277 ASN A CA  1 
ATOM   2151 C C   . ASN A 1 277 ? 6.14056   33.07131 1.67148   1.000 24.18211 ? 277 ASN A C   1 
ATOM   2152 O O   . ASN A 1 277 ? 6.91137   34.01912 1.82228   1.000 39.72660 ? 277 ASN A O   1 
ATOM   2153 C CB  . ASN A 1 277 ? 7.64223   31.75734 3.20719   1.000 34.97067 ? 277 ASN A CB  1 
ATOM   2154 C CG  . ASN A 1 277 ? 7.71520   30.60173 4.18415   1.000 56.52845 ? 277 ASN A CG  1 
ATOM   2155 O OD1 . ASN A 1 277 ? 8.04776   29.47566 3.81113   1.000 55.40335 ? 277 ASN A OD1 1 
ATOM   2156 N ND2 . ASN A 1 277 ? 7.40599   30.87534 5.44603   1.000 65.09423 ? 277 ASN A ND2 1 
ATOM   2157 N N   . GLY A 1 278 ? 5.04799   33.14357 0.91531   1.000 33.77590 ? 278 GLY A N   1 
ATOM   2158 C CA  . GLY A 1 278 ? 4.66900   34.37481 0.25630   1.000 31.47857 ? 278 GLY A CA  1 
ATOM   2159 C C   . GLY A 1 278 ? 5.59400   34.83981 -0.84625  1.000 37.07336 ? 278 GLY A C   1 
ATOM   2160 O O   . GLY A 1 278 ? 5.33293   35.89126 -1.44326  1.000 34.46216 ? 278 GLY A O   1 
ATOM   2161 N N   . ARG A 1 279 ? 6.66938   34.10925 -1.12802  1.000 25.48689 ? 279 ARG A N   1 
ATOM   2162 C CA  A ARG A 1 279 ? 7.56268   34.44545 -2.22271  0.500 22.55275 ? 279 ARG A CA  1 
ATOM   2163 C CA  B ARG A 1 279 ? 7.55363   34.46546 -2.22406  0.500 22.54815 ? 279 ARG A CA  1 
ATOM   2164 C C   . ARG A 1 279 ? 6.98298   33.97542 -3.55262  1.000 19.32340 ? 279 ARG A C   1 
ATOM   2165 O O   . ARG A 1 279 ? 6.10170   33.11517 -3.60683  1.000 23.98343 ? 279 ARG A O   1 
ATOM   2166 C CB  A ARG A 1 279 ? 8.93182   33.80552 -2.01038  0.500 25.91079 ? 279 ARG A CB  1 
ATOM   2167 C CB  B ARG A 1 279 ? 8.94852   33.87235 -2.01770  0.500 25.89756 ? 279 ARG A CB  1 
ATOM   2168 C CG  A ARG A 1 279 ? 9.83127   34.55266 -1.05580  0.500 24.34253 ? 279 ARG A CG  1 
ATOM   2169 C CG  B ARG A 1 279 ? 9.66356   34.32449 -0.75251  0.500 25.77527 ? 279 ARG A CG  1 
ATOM   2170 C CD  A ARG A 1 279 ? 10.61042  35.61289 -1.79400  0.500 33.50450 ? 279 ARG A CD  1 
ATOM   2171 C CD  B ARG A 1 279 ? 10.10507  35.77527 -0.83649  0.500 30.64002 ? 279 ARG A CD  1 
ATOM   2172 N NE  A ARG A 1 279 ? 12.00476  35.61449 -1.37667  0.500 28.84257 ? 279 ARG A NE  1 
ATOM   2173 N NE  B ARG A 1 279 ? 10.95689  36.03039 -1.99288  0.500 32.75472 ? 279 ARG A NE  1 
ATOM   2174 C CZ  A ARG A 1 279 ? 12.99445  36.16791 -2.06375  0.500 18.90652 ? 279 ARG A CZ  1 
ATOM   2175 C CZ  B ARG A 1 279 ? 12.27856  35.91393 -2.00185  0.500 27.61979 ? 279 ARG A CZ  1 
ATOM   2176 N NH1 A ARG A 1 279 ? 12.77996  36.77038 -3.22330  0.500 29.57576 ? 279 ARG A NH1 1 
ATOM   2177 N NH1 B ARG A 1 279 ? 12.94883  35.51178 -0.93265  0.500 26.50608 ? 279 ARG A NH1 1 
ATOM   2178 N NH2 A ARG A 1 279 ? 14.22967  36.10781 -1.58031  0.500 24.94223 ? 279 ARG A NH2 1 
ATOM   2179 N NH2 B ARG A 1 279 ? 12.94705  36.21360 -3.11157  0.500 32.09163 ? 279 ARG A NH2 1 
ATOM   2180 N N   . THR A 1 280 ? 7.49734   34.54783 -4.63590  1.000 16.38386 ? 280 THR A N   1 
ATOM   2181 C CA  . THR A 1 280 ? 7.17166   34.09494 -5.97763  1.000 15.21312 ? 280 THR A CA  1 
ATOM   2182 C C   . THR A 1 280 ? 8.43877   33.64557 -6.69349  1.000 13.47884 ? 280 THR A C   1 
ATOM   2183 O O   . THR A 1 280 ? 9.56127   34.01996 -6.33074  1.000 16.60028 ? 280 THR A O   1 
ATOM   2184 C CB  . THR A 1 280 ? 6.48655   35.18591 -6.81272  1.000 14.81866 ? 280 THR A CB  1 
ATOM   2185 O OG1 . THR A 1 280 ? 7.33380   36.34373 -6.88945  1.000 18.03006 ? 280 THR A OG1 1 
ATOM   2186 C CG2 . THR A 1 280 ? 5.12618   35.56117 -6.21116  1.000 17.42148 ? 280 THR A CG2 1 
ATOM   2187 N N   . ILE A 1 281 ? 8.23708   32.81789 -7.71200  1.000 14.25535 ? 281 ILE A N   1 
ATOM   2188 C CA  . ILE A 1 281 ? 9.29340   32.40085 -8.62472  1.000 16.24756 ? 281 ILE A CA  1 
ATOM   2189 C C   . ILE A 1 281 ? 8.80529   32.73940 -10.02057 1.000 16.56648 ? 281 ILE A C   1 
ATOM   2190 O O   . ILE A 1 281 ? 7.70642   32.32194 -10.40917 1.000 16.58167 ? 281 ILE A O   1 
ATOM   2191 C CB  . ILE A 1 281 ? 9.61892   30.90211 -8.49478  1.000 14.56322 ? 281 ILE A CB  1 
ATOM   2192 C CG1 . ILE A 1 281 ? 10.12886  30.60559 -7.08185  1.000 11.18547 ? 281 ILE A CG1 1 
ATOM   2193 C CG2 . ILE A 1 281 ? 10.64389  30.48389 -9.54171  1.000 15.59138 ? 281 ILE A CG2 1 
ATOM   2194 C CD1 . ILE A 1 281 ? 10.27074  29.12438 -6.77338  1.000 14.34182 ? 281 ILE A CD1 1 
ATOM   2195 N N   . LEU A 1 282 ? 9.59545   33.53046 -10.75608 1.000 14.69036 ? 282 LEU A N   1 
ATOM   2196 C CA  . LEU A 1 282 ? 9.19642   34.02101 -12.07514 1.000 16.44265 ? 282 LEU A CA  1 
ATOM   2197 C C   . LEU A 1 282 ? 7.77930   34.58468 -12.03382 1.000 16.40417 ? 282 LEU A C   1 
ATOM   2198 O O   . LEU A 1 282 ? 6.96512   34.36015 -12.93274 1.000 17.64555 ? 282 LEU A O   1 
ATOM   2199 C CB  . LEU A 1 282 ? 9.32404   32.92516 -13.13363 1.000 14.07868 ? 282 LEU A CB  1 
ATOM   2200 C CG  . LEU A 1 282 ? 10.75424  32.57543 -13.56094 1.000 15.10963 ? 282 LEU A CG  1 
ATOM   2201 C CD1 . LEU A 1 282 ? 10.75471  31.32831 -14.42724 1.000 15.25819 ? 282 LEU A CD1 1 
ATOM   2202 C CD2 . LEU A 1 282 ? 11.39169  33.74326 -14.31090 1.000 13.06460 ? 282 LEU A CD2 1 
ATOM   2203 N N   . GLY A 1 283 ? 7.47487   35.29900 -10.94930 1.000 13.96401 ? 283 GLY A N   1 
ATOM   2204 C CA  . GLY A 1 283 ? 6.19707   35.95887 -10.79140 1.000 17.06889 ? 283 GLY A CA  1 
ATOM   2205 C C   . GLY A 1 283 ? 5.06103   35.07797 -10.33027 1.000 19.42807 ? 283 GLY A C   1 
ATOM   2206 O O   . GLY A 1 283 ? 3.96597   35.59698 -10.07388 1.000 20.12527 ? 283 GLY A O   1 
ATOM   2207 N N   . SER A 1 284 ? 5.27098   33.76948 -10.21759 1.000 15.54463 ? 284 SER A N   1 
ATOM   2208 C CA  A SER A 1 284 ? 4.21891   32.83800 -9.83799  0.500 15.78682 ? 284 SER A CA  1 
ATOM   2209 C CA  B SER A 1 284 ? 4.22227   32.83212 -9.83871  0.500 15.79533 ? 284 SER A CA  1 
ATOM   2210 C C   . SER A 1 284 ? 4.31342   32.49554 -8.35805  1.000 15.19818 ? 284 SER A C   1 
ATOM   2211 O O   . SER A 1 284 ? 5.40526   32.27929 -7.82644  1.000 14.86276 ? 284 SER A O   1 
ATOM   2212 C CB  A SER A 1 284 ? 4.30550   31.55664 -10.66839 0.500 16.46294 ? 284 SER A CB  1 
ATOM   2213 C CB  B SER A 1 284 ? 4.32411   31.54491 -10.65836 0.500 16.43998 ? 284 SER A CB  1 
ATOM   2214 O OG  A SER A 1 284 ? 3.34061   30.61212 -10.23695 0.500 15.36127 ? 284 SER A OG  1 
ATOM   2215 O OG  B SER A 1 284 ? 4.09485   31.79523 -12.03064 0.500 15.63209 ? 284 SER A OG  1 
ATOM   2216 N N   . ALA A 1 285 ? 3.15650   32.43819 -7.69672  1.000 17.05664 ? 285 ALA A N   1 
ATOM   2217 C CA  . ALA A 1 285 ? 3.08987   32.00610 -6.30858  1.000 16.55971 ? 285 ALA A CA  1 
ATOM   2218 C C   . ALA A 1 285 ? 2.93868   30.49832 -6.17203  1.000 17.69632 ? 285 ALA A C   1 
ATOM   2219 O O   . ALA A 1 285 ? 3.08574   29.96992 -5.06432  1.000 22.84671 ? 285 ALA A O   1 
ATOM   2220 C CB  . ALA A 1 285 ? 1.92807   32.69991 -5.59098  1.000 17.93527 ? 285 ALA A CB  1 
ATOM   2221 N N   . LEU A 1 286 ? 2.64245   29.80223 -7.26399  1.000 18.43561 ? 286 LEU A N   1 
ATOM   2222 C CA  . LEU A 1 286 ? 2.55555   28.35249 -7.30088  1.000 12.49252 ? 286 LEU A CA  1 
ATOM   2223 C C   . LEU A 1 286 ? 3.61594   27.82423 -8.25649  1.000 17.41389 ? 286 LEU A C   1 
ATOM   2224 O O   . LEU A 1 286 ? 3.98612   28.49779 -9.22089  1.000 19.71265 ? 286 LEU A O   1 
ATOM   2225 C CB  . LEU A 1 286 ? 1.17661   27.89020 -7.76014  1.000 14.73346 ? 286 LEU A CB  1 
ATOM   2226 C CG  . LEU A 1 286 ? 0.00492   28.40364 -6.92769  1.000 20.45602 ? 286 LEU A CG  1 
ATOM   2227 C CD1 . LEU A 1 286 ? -1.30907  28.05238 -7.60616  1.000 28.43936 ? 286 LEU A CD1 1 
ATOM   2228 C CD2 . LEU A 1 286 ? 0.06925   27.82755 -5.52667  1.000 20.18633 ? 286 LEU A CD2 1 
ATOM   2229 N N   . LEU A 1 287 ? 4.10175   26.61559 -7.98866  1.000 14.63618 ? 287 LEU A N   1 
ATOM   2230 C CA  . LEU A 1 287 ? 5.08968   26.01445 -8.87222  1.000 15.49085 ? 287 LEU A CA  1 
ATOM   2231 C C   . LEU A 1 287 ? 4.43136   25.61919 -10.18862 1.000 15.12928 ? 287 LEU A C   1 
ATOM   2232 O O   . LEU A 1 287 ? 3.32195   25.08566 -10.21175 1.000 18.13279 ? 287 LEU A O   1 
ATOM   2233 C CB  . LEU A 1 287 ? 5.74153   24.80233 -8.20047  1.000 17.75556 ? 287 LEU A CB  1 
ATOM   2234 C CG  . LEU A 1 287 ? 6.38682   25.08958 -6.84045  1.000 15.83264 ? 287 LEU A CG  1 
ATOM   2235 C CD1 . LEU A 1 287 ? 7.06434   23.85862 -6.23270  1.000 16.84857 ? 287 LEU A CD1 1 
ATOM   2236 C CD2 . LEU A 1 287 ? 7.38307   26.23608 -6.97200  1.000 17.76079 ? 287 LEU A CD2 1 
ATOM   2237 N N   . GLU A 1 288 ? 5.10033   25.92362 -11.29304 1.000 12.06238 ? 288 GLU A N   1 
ATOM   2238 C CA  . GLU A 1 288 ? 4.54623   25.71983 -12.62734 1.000 12.69132 ? 288 GLU A CA  1 
ATOM   2239 C C   . GLU A 1 288 ? 5.09387   24.44305 -13.25373 1.000 12.66576 ? 288 GLU A C   1 
ATOM   2240 O O   . GLU A 1 288 ? 6.30114   24.18717 -13.21463 1.000 12.39044 ? 288 GLU A O   1 
ATOM   2241 C CB  . GLU A 1 288 ? 4.84907   26.91389 -13.53135 1.000 13.93126 ? 288 GLU A CB  1 
ATOM   2242 C CG  . GLU A 1 288 ? 4.28465   28.21070 -13.01400 1.000 19.02149 ? 288 GLU A CG  1 
ATOM   2243 C CD  . GLU A 1 288 ? 3.84170   29.13315 -14.12779 1.000 36.26198 ? 288 GLU A CD  1 
ATOM   2244 O OE1 . GLU A 1 288 ? 3.61789   28.64116 -15.25615 1.000 33.67996 ? 288 GLU A OE1 1 
ATOM   2245 O OE2 . GLU A 1 288 ? 3.71602   30.34795 -13.87366 1.000 42.53513 ? 288 GLU A OE2 1 
ATOM   2246 N N   . ASP A 1 289 ? 4.20207   23.65212 -13.86055 1.000 14.25280 ? 289 ASP A N   1 
ATOM   2247 C CA  . ASP A 1 289 ? 4.61601   22.37400 -14.42613 1.000 11.89966 ? 289 ASP A CA  1 
ATOM   2248 C C   . ASP A 1 289 ? 4.21466   22.19337 -15.88979 1.000 12.36362 ? 289 ASP A C   1 
ATOM   2249 O O   . ASP A 1 289 ? 4.14833   21.05173 -16.35952 1.000 11.93391 ? 289 ASP A O   1 
ATOM   2250 C CB  . ASP A 1 289 ? 4.08571   21.20421 -13.58018 1.000 13.75973 ? 289 ASP A CB  1 
ATOM   2251 C CG  . ASP A 1 289 ? 2.60474   20.93530 -13.78435 1.000 13.12281 ? 289 ASP A CG  1 
ATOM   2252 O OD1 . ASP A 1 289 ? 1.90217   21.77269 -14.38552 1.000 13.14444 ? 289 ASP A OD1 1 
ATOM   2253 O OD2 . ASP A 1 289 ? 2.15213   19.87413 -13.31106 1.000 13.37298 ? 289 ASP A OD2 1 
ATOM   2254 N N   . GLU A 1 290 ? 3.97285   23.27415 -16.63646 1.000 13.22048 ? 290 GLU A N   1 
ATOM   2255 C CA  . GLU A 1 290 ? 3.65032   23.12864 -18.05433 1.000 12.64325 ? 290 GLU A CA  1 
ATOM   2256 C C   . GLU A 1 290 ? 4.70158   23.77162 -18.96115 1.000 13.73813 ? 290 GLU A C   1 
ATOM   2257 O O   . GLU A 1 290 ? 4.38040   24.22394 -20.06765 1.000 12.85245 ? 290 GLU A O   1 
ATOM   2258 C CB  . GLU A 1 290 ? 2.24099   23.65477 -18.35010 1.000 14.70476 ? 290 GLU A CB  1 
ATOM   2259 C CG  . GLU A 1 290 ? 1.14691   22.83712 -17.61093 1.000 14.36571 ? 290 GLU A CG  1 
ATOM   2260 C CD  . GLU A 1 290 ? -0.23417  22.83457 -18.26768 1.000 17.08319 ? 290 GLU A CD  1 
ATOM   2261 O OE1 . GLU A 1 290 ? -0.49608  23.61708 -19.20603 1.000 14.86749 ? 290 GLU A OE1 1 
ATOM   2262 O OE2 . GLU A 1 290 ? -1.08308  22.02758 -17.82849 1.000 17.71155 ? 290 GLU A OE2 1 
ATOM   2263 N N   . PHE A 1 291 ? 5.96690   23.79245 -18.51709 1.000 11.38576 ? 291 PHE A N   1 
ATOM   2264 C CA  . PHE A 1 291 ? 7.12765   23.98561 -19.39439 1.000 10.57810 ? 291 PHE A CA  1 
ATOM   2265 C C   . PHE A 1 291 ? 7.98642   22.72625 -19.36410 1.000 13.14277 ? 291 PHE A C   1 
ATOM   2266 O O   . PHE A 1 291 ? 8.44828   22.32136 -18.29216 1.000 13.50558 ? 291 PHE A O   1 
ATOM   2267 C CB  . PHE A 1 291 ? 8.00099   25.16975 -18.96291 1.000 12.33547 ? 291 PHE A CB  1 
ATOM   2268 C CG  . PHE A 1 291 ? 7.31342   26.49742 -18.98203 1.000 14.57872 ? 291 PHE A CG  1 
ATOM   2269 C CD1 . PHE A 1 291 ? 7.26196   27.25109 -20.14221 1.000 12.49377 ? 291 PHE A CD1 1 
ATOM   2270 C CD2 . PHE A 1 291 ? 6.77596   27.01864 -17.82306 1.000 13.85077 ? 291 PHE A CD2 1 
ATOM   2271 C CE1 . PHE A 1 291 ? 6.65061   28.48787 -20.15027 1.000 16.82007 ? 291 PHE A CE1 1 
ATOM   2272 C CE2 . PHE A 1 291 ? 6.15381   28.26589 -17.82141 1.000 18.79056 ? 291 PHE A CE2 1 
ATOM   2273 C CZ  . PHE A 1 291 ? 6.09713   28.99615 -18.98745 1.000 16.92540 ? 291 PHE A CZ  1 
ATOM   2274 N N   . THR A 1 292 ? 8.23795   22.13607 -20.53794 1.000 13.41396 ? 292 THR A N   1 
ATOM   2275 C CA  . THR A 1 292 ? 9.19096   21.04213 -20.61130 1.000 14.37859 ? 292 THR A CA  1 
ATOM   2276 C C   . THR A 1 292 ? 10.61441  21.58149 -20.60371 1.000 10.59154 ? 292 THR A C   1 
ATOM   2277 O O   . THR A 1 292 ? 10.84023  22.76969 -20.84905 1.000 12.98405 ? 292 THR A O   1 
ATOM   2278 C CB  . THR A 1 292 ? 8.98267   20.21464 -21.87618 1.000 14.14745 ? 292 THR A CB  1 
ATOM   2279 O OG1 . THR A 1 292 ? 9.33965   20.99475 -23.02629 1.000 13.95020 ? 292 THR A OG1 1 
ATOM   2280 C CG2 . THR A 1 292 ? 7.52761   19.76651 -22.00434 1.000 13.21949 ? 292 THR A CG2 1 
ATOM   2281 N N   . PRO A 1 293 ? 11.60098  20.71927 -20.33545 1.000 12.74551 ? 293 PRO A N   1 
ATOM   2282 C CA  . PRO A 1 293 ? 12.99834  21.14882 -20.48695 1.000 11.03864 ? 293 PRO A CA  1 
ATOM   2283 C C   . PRO A 1 293 ? 13.27856  21.75907 -21.85035 1.000 13.24157 ? 293 PRO A C   1 
ATOM   2284 O O   . PRO A 1 293 ? 13.94650  22.79791 -21.94109 1.000 15.63917 ? 293 PRO A O   1 
ATOM   2285 C CB  . PRO A 1 293 ? 13.77997  19.84454 -20.26169 1.000 13.83155 ? 293 PRO A CB  1 
ATOM   2286 C CG  . PRO A 1 293 ? 12.88633  19.03651 -19.34951 1.000 12.11787 ? 293 PRO A CG  1 
ATOM   2287 C CD  . PRO A 1 293 ? 11.49450  19.33497 -19.84219 1.000 11.24531 ? 293 PRO A CD  1 
ATOM   2288 N N   . PHE A 1 294 ? 12.77737  21.14777 -22.92185 1.000 13.17283 ? 294 PHE A N   1 
ATOM   2289 C CA  . PHE A 1 294 ? 13.03050  21.72341 -24.23510 1.000 14.28485 ? 294 PHE A CA  1 
ATOM   2290 C C   . PHE A 1 294 ? 12.31565  23.05465 -24.42025 1.000 14.22096 ? 294 PHE A C   1 
ATOM   2291 O O   . PHE A 1 294 ? 12.85957  23.95151 -25.06981 1.000 16.61472 ? 294 PHE A O   1 
ATOM   2292 C CB  . PHE A 1 294 ? 12.63858  20.74186 -25.33206 1.000 17.77385 ? 294 PHE A CB  1 
ATOM   2293 C CG  . PHE A 1 294 ? 13.05326  21.18736 -26.70385 1.000 39.89238 ? 294 PHE A CG  1 
ATOM   2294 C CD1 . PHE A 1 294 ? 14.32054  21.71123 -26.91582 1.000 33.21481 ? 294 PHE A CD1 1 
ATOM   2295 C CD2 . PHE A 1 294 ? 12.18575  21.09037 -27.77777 1.000 36.84090 ? 294 PHE A CD2 1 
ATOM   2296 C CE1 . PHE A 1 294 ? 14.71161  22.12986 -28.16960 1.000 39.62974 ? 294 PHE A CE1 1 
ATOM   2297 C CE2 . PHE A 1 294 ? 12.57743  21.50355 -29.03784 1.000 44.66820 ? 294 PHE A CE2 1 
ATOM   2298 C CZ  . PHE A 1 294 ? 13.83941  22.02292 -29.23163 1.000 35.92148 ? 294 PHE A CZ  1 
ATOM   2299 N N   . ASP A 1 295 ? 11.11652  23.21735 -23.84894 1.000 12.33505 ? 295 ASP A N   1 
ATOM   2300 C CA  . ASP A 1 295 ? 10.46509  24.52192 -23.89423 1.000 14.06334 ? 295 ASP A CA  1 
ATOM   2301 C C   . ASP A 1 295 ? 11.36103  25.59795 -23.30668 1.000 15.61115 ? 295 ASP A C   1 
ATOM   2302 O O   . ASP A 1 295 ? 11.45768  26.70181 -23.85178 1.000 16.68593 ? 295 ASP A O   1 
ATOM   2303 C CB  . ASP A 1 295 ? 9.13996   24.50785 -23.12520 1.000 12.30863 ? 295 ASP A CB  1 
ATOM   2304 C CG  . ASP A 1 295 ? 8.06233   23.67009 -23.79021 1.000 14.77750 ? 295 ASP A CG  1 
ATOM   2305 O OD1 . ASP A 1 295 ? 8.18870   23.33009 -24.98898 1.000 19.57147 ? 295 ASP A OD1 1 
ATOM   2306 O OD2 . ASP A 1 295 ? 7.07898   23.35820 -23.08723 1.000 14.05554 ? 295 ASP A OD2 1 
ATOM   2307 N N   . VAL A 1 296 ? 12.00329  25.30329 -22.17221 1.000 12.69542 ? 296 VAL A N   1 
ATOM   2308 C CA  . VAL A 1 296 ? 12.84793  26.29487 -21.51646 1.000 13.26405 ? 296 VAL A CA  1 
ATOM   2309 C C   . VAL A 1 296 ? 14.05965  26.62718 -22.38364 1.000 17.30948 ? 296 VAL A C   1 
ATOM   2310 O O   . VAL A 1 296 ? 14.42952  27.79706 -22.54075 1.000 15.84346 ? 296 VAL A O   1 
ATOM   2311 C CB  . VAL A 1 296 ? 13.26777  25.79999 -20.11937 1.000 12.70511 ? 296 VAL A CB  1 
ATOM   2312 C CG1 . VAL A 1 296 ? 14.31414  26.74392 -19.52408 1.000 15.53775 ? 296 VAL A CG1 1 
ATOM   2313 C CG2 . VAL A 1 296 ? 12.05764  25.69032 -19.19894 1.000 14.91393 ? 296 VAL A CG2 1 
ATOM   2314 N N   . VAL A 1 297 ? 14.69524  25.61005 -22.96330 1.000 14.53747 ? 297 VAL A N   1 
ATOM   2315 C CA  . VAL A 1 297 ? 15.85582  25.85646 -23.81768 1.000 14.91977 ? 297 VAL A CA  1 
ATOM   2316 C C   . VAL A 1 297 ? 15.45194  26.64691 -25.05941 1.000 17.04161 ? 297 VAL A C   1 
ATOM   2317 O O   . VAL A 1 297 ? 16.13582  27.59774 -25.45541 1.000 20.09943 ? 297 VAL A O   1 
ATOM   2318 C CB  . VAL A 1 297 ? 16.53591  24.52568 -24.17886 1.000 16.09442 ? 297 VAL A CB  1 
ATOM   2319 C CG1 . VAL A 1 297 ? 17.55745  24.73279 -25.29202 1.000 19.75047 ? 297 VAL A CG1 1 
ATOM   2320 C CG2 . VAL A 1 297 ? 17.20321  23.92758 -22.94836 1.000 20.00389 ? 297 VAL A CG2 1 
ATOM   2321 N N   . ARG A 1 298 ? 14.33536  26.27401 -25.69047 1.000 17.28689 ? 298 ARG A N   1 
ATOM   2322 C CA  . ARG A 1 298 ? 13.85692  27.01079 -26.85911 1.000 13.87891 ? 298 ARG A CA  1 
ATOM   2323 C C   . ARG A 1 298 ? 13.67244  28.48830 -26.53766 1.000 17.79085 ? 298 ARG A C   1 
ATOM   2324 O O   . ARG A 1 298 ? 14.16875  29.36463 -27.25607 1.000 22.12335 ? 298 ARG A O   1 
ATOM   2325 C CB  . ARG A 1 298 ? 12.52925  26.43118 -27.35580 1.000 18.70098 ? 298 ARG A CB  1 
ATOM   2326 C CG  . ARG A 1 298 ? 12.62944  25.17265 -28.19264 1.000 28.89039 ? 298 ARG A CG  1 
ATOM   2327 C CD  . ARG A 1 298 ? 11.32279  24.90469 -28.96129 1.000 35.32047 ? 298 ARG A CD  1 
ATOM   2328 N NE  . ARG A 1 298 ? 10.17488  24.67727 -28.08731 1.000 38.93502 ? 298 ARG A NE  1 
ATOM   2329 C CZ  . ARG A 1 298 ? 9.17918   25.53751 -27.90348 1.000 50.69243 ? 298 ARG A CZ  1 
ATOM   2330 N NH1 . ARG A 1 298 ? 9.14460   26.70505 -28.52675 1.000 46.98776 ? 298 ARG A NH1 1 
ATOM   2331 N NH2 . ARG A 1 298 ? 8.18672   25.21504 -27.07891 1.000 46.83682 ? 298 ARG A NH2 1 
ATOM   2332 N N   . GLN A 1 299 ? 12.93430  28.78405 -25.46655 1.000 18.54489 ? 299 GLN A N   1 
ATOM   2333 C CA  . GLN A 1 299 ? 12.60372  30.16989 -25.17237 1.000 15.52136 ? 299 GLN A CA  1 
ATOM   2334 C C   . GLN A 1 299 ? 13.84063  30.95409 -24.76038 1.000 20.02255 ? 299 GLN A C   1 
ATOM   2335 O O   . GLN A 1 299 ? 14.04293  32.08738 -25.21379 1.000 22.54896 ? 299 GLN A O   1 
ATOM   2336 C CB  . GLN A 1 299 ? 11.53121  30.24802 -24.08249 1.000 14.15665 ? 299 GLN A CB  1 
ATOM   2337 C CG  . GLN A 1 299 ? 11.24988  31.68547 -23.67987 1.000 16.80222 ? 299 GLN A CG  1 
ATOM   2338 C CD  . GLN A 1 299 ? 10.01177  31.86275 -22.82448 1.000 15.06689 ? 299 GLN A CD  1 
ATOM   2339 O OE1 . GLN A 1 299 ? 9.79561   32.93711 -22.26000 1.000 16.71420 ? 299 GLN A OE1 1 
ATOM   2340 N NE2 . GLN A 1 299 ? 9.18954   30.81760 -22.71935 1.000 16.09579 ? 299 GLN A NE2 1 
ATOM   2341 N N   . CYS A 1 300 ? 14.68443  30.37023 -23.91174 1.000 19.19647 ? 300 CYS A N   1 
ATOM   2342 C CA  . CYS A 1 300 ? 15.84571  31.10192 -23.43499 1.000 20.32393 ? 300 CYS A CA  1 
ATOM   2343 C C   . CYS A 1 300 ? 16.94034  31.21987 -24.49065 1.000 21.74111 ? 300 CYS A C   1 
ATOM   2344 O O   . CYS A 1 300 ? 17.81852  32.07531 -24.34979 1.000 23.77012 ? 300 CYS A O   1 
ATOM   2345 C CB  . CYS A 1 300 ? 16.39464  30.44023 -22.17340 1.000 20.38168 ? 300 CYS A CB  1 
ATOM   2346 S SG  . CYS A 1 300 ? 15.24393  30.48860 -20.77371 1.000 22.83587 ? 300 CYS A SG  1 
ATOM   2347 N N   . SER A 1 301 ? 16.90569  30.39912 -25.54719 1.000 20.56463 ? 301 SER A N   1 
ATOM   2348 C CA  . SER A 1 301 ? 17.89447  30.47987 -26.61628 1.000 20.63866 ? 301 SER A CA  1 
ATOM   2349 C C   . SER A 1 301 ? 17.35622  31.06407 -27.91610 1.000 27.35485 ? 301 SER A C   1 
ATOM   2350 O O   . SER A 1 301 ? 18.14058  31.26528 -28.85056 1.000 27.01431 ? 301 SER A O   1 
ATOM   2351 C CB  . SER A 1 301 ? 18.48559  29.09189 -26.90617 1.000 26.33728 ? 301 SER A CB  1 
ATOM   2352 O OG  . SER A 1 301 ? 17.56656  28.29463 -27.62601 1.000 26.70404 ? 301 SER A OG  1 
ATOM   2353 N N   . GLY A 1 302 ? 16.05602  31.32629 -28.01286 1.000 26.91919 ? 302 GLY A N   1 
ATOM   2354 C CA  . GLY A 1 302 ? 15.50848  31.95840 -29.20502 1.000 20.51514 ? 302 GLY A CA  1 
ATOM   2355 C C   . GLY A 1 302 ? 15.42771  31.07358 -30.43269 1.000 28.50671 ? 302 GLY A C   1 
ATOM   2356 O O   . GLY A 1 302 ? 15.70730  31.54027 -31.54622 1.000 25.14772 ? 302 GLY A O   1 
ATOM   2357 N N   . VAL A 1 303 ? 15.03960  29.80798 -30.26247 1.000 21.91407 ? 303 VAL A N   1 
ATOM   2358 C CA  . VAL A 1 303 ? 14.88421  28.91300 -31.40347 1.000 22.95147 ? 303 VAL A CA  1 
ATOM   2359 C C   . VAL A 1 303 ? 13.74114  29.40349 -32.28093 1.000 22.57297 ? 303 VAL A C   1 
ATOM   2360 O O   . VAL A 1 303 ? 12.69141  29.82494 -31.78245 1.000 23.66324 ? 303 VAL A O   1 
ATOM   2361 C CB  . VAL A 1 303 ? 14.63878  27.47026 -30.92731 1.000 19.76047 ? 303 VAL A CB  1 
ATOM   2362 C CG1 . VAL A 1 303 ? 14.24263  26.58886 -32.09879 1.000 21.52246 ? 303 VAL A CG1 1 
ATOM   2363 C CG2 . VAL A 1 303 ? 15.88824  26.91035 -30.22838 1.000 20.54476 ? 303 VAL A CG2 1 
ATOM   2364 N N   . THR A 1 304 ? 13.93871  29.35284 -33.59735 1.000 22.37940 ? 304 THR A N   1 
ATOM   2365 C CA  . THR A 1 304 ? 12.95727  29.83728 -34.55921 1.000 18.73214 ? 304 THR A CA  1 
ATOM   2366 C C   . THR A 1 304 ? 12.49911  28.70453 -35.46935 1.000 21.61495 ? 304 THR A C   1 
ATOM   2367 O O   . THR A 1 304 ? 13.05713  27.60189 -35.46720 1.000 23.47700 ? 304 THR A O   1 
ATOM   2368 C CB  . THR A 1 304 ? 13.52825  30.98178 -35.40724 1.000 24.63151 ? 304 THR A CB  1 
ATOM   2369 O OG1 . THR A 1 304 ? 14.69955  30.52471 -36.09646 1.000 26.17376 ? 304 THR A OG1 1 
ATOM   2370 C CG2 . THR A 1 304 ? 13.88670  32.16718 -34.52607 1.000 18.66808 ? 304 THR A CG2 1 
ATOM   2371 N N   . PHE A 1 305 ? 11.47157  28.99947 -36.26171 1.000 21.98306 ? 306 PHE A N   1 
ATOM   2372 C CA  . PHE A 1 305 ? 10.87908  28.01689 -37.16405 1.000 22.55498 ? 306 PHE A CA  1 
ATOM   2373 C C   . PHE A 1 305 ? 10.72609  28.56826 -38.57839 1.000 29.57322 ? 306 PHE A C   1 
ATOM   2374 O O   . PHE A 1 305 ? 10.64525  29.78216 -38.77202 1.000 29.86448 ? 306 PHE A O   1 
ATOM   2375 C CB  . PHE A 1 305 ? 9.52574   27.56958 -36.62134 1.000 25.48038 ? 306 PHE A CB  1 
ATOM   2376 C CG  . PHE A 1 305 ? 9.56104   27.22363 -35.16823 1.000 31.65524 ? 306 PHE A CG  1 
ATOM   2377 C CD1 . PHE A 1 305 ? 10.04263  25.99273 -34.74785 1.000 23.83273 ? 306 PHE A CD1 1 
ATOM   2378 C CD2 . PHE A 1 305 ? 9.14891   28.14192 -34.21630 1.000 23.70609 ? 306 PHE A CD2 1 
ATOM   2379 C CE1 . PHE A 1 305 ? 10.08974  25.68221 -33.40152 1.000 25.61516 ? 306 PHE A CE1 1 
ATOM   2380 C CE2 . PHE A 1 305 ? 9.19514   27.83697 -32.87034 1.000 29.89142 ? 306 PHE A CE2 1 
ATOM   2381 C CZ  . PHE A 1 305 ? 9.66864   26.60718 -32.46240 1.000 28.75345 ? 306 PHE A CZ  1 
HETATM 2382 C C8  . 4WI B 2 .   ? -16.14589 21.42823 -25.19664 1.000 12.60495 ? 401 4WI A C8  1 
HETATM 2383 C C3  . 4WI B 2 .   ? -17.08645 19.71119 -29.69877 1.000 17.96746 ? 401 4WI A C3  1 
HETATM 2384 C C1  . 4WI B 2 .   ? -18.90777 17.84838 -27.36136 1.000 11.58367 ? 401 4WI A C1  1 
HETATM 2385 C C13 . 4WI B 2 .   ? -19.13274 16.78081 -24.58268 1.000 15.47579 ? 401 4WI A C13 1 
HETATM 2386 C C21 . 4WI B 2 .   ? -19.21970 14.58402 -22.09744 1.000 16.44987 ? 401 4WI A C21 1 
HETATM 2387 C C6  . 4WI B 2 .   ? -18.41542 21.60171 -25.97099 1.000 16.43732 ? 401 4WI A C6  1 
HETATM 2388 C C7  . 4WI B 2 .   ? -18.26576 22.30762 -24.63530 1.000 17.10772 ? 401 4WI A C7  1 
HETATM 2389 C C10 . 4WI B 2 .   ? -20.87170 15.41621 -25.94249 1.000 16.28539 ? 401 4WI A C10 1 
HETATM 2390 C C5  . 4WI B 2 .   ? -17.18875 20.69936 -26.03231 1.000 11.66264 ? 401 4WI A C5  1 
HETATM 2391 C C9  . 4WI B 2 .   ? -18.89166 16.37348 -27.00103 1.000 14.91268 ? 401 4WI A C9  1 
HETATM 2392 C C11 . 4WI B 2 .   ? -20.80231 14.93777 -27.35322 1.000 13.69281 ? 401 4WI A C11 1 
HETATM 2393 C C12 . 4WI B 2 .   ? -19.62340 15.53308 -28.05242 1.000 13.40364 ? 401 4WI A C12 1 
HETATM 2394 C C18 . 4WI B 2 .   ? -19.58111 14.06323 -27.66701 1.000 20.88593 ? 401 4WI A C18 1 
HETATM 2395 C C19 . 4WI B 2 .   ? -19.73981 13.03569 -28.74533 1.000 14.94088 ? 401 4WI A C19 1 
HETATM 2396 C C20 . 4WI B 2 .   ? -18.65313 13.55469 -26.60760 1.000 17.77147 ? 401 4WI A C20 1 
HETATM 2397 C C16 . 4WI B 2 .   ? -19.29679 18.89485 -22.37046 1.000 15.55032 ? 401 4WI A C16 1 
HETATM 2398 C C17 . 4WI B 2 .   ? -21.27875 17.60592 -21.52328 1.000 17.16912 ? 401 4WI A C17 1 
HETATM 2399 C C23 . 4WI B 2 .   ? -21.30918 18.55897 -23.84720 1.000 16.79900 ? 401 4WI A C23 1 
HETATM 2400 C C4  . 4WI B 2 .   ? -16.64569 20.51687 -27.42898 1.000 12.61003 ? 401 4WI A C4  1 
HETATM 2401 C C2  . 4WI B 2 .   ? -17.60987 19.73143 -28.28314 1.000 14.99682 ? 401 4WI A C2  1 
HETATM 2402 C C14 . 4WI B 2 .   ? -19.94393 16.62496 -23.30308 1.000 12.92740 ? 401 4WI A C14 1 
HETATM 2403 C C22 . 4WI B 2 .   ? -18.19964 14.01410 -21.15481 1.000 21.22051 ? 401 4WI A C22 1 
HETATM 2404 C C15 . 4WI B 2 .   ? -20.43161 17.94006 -22.75792 1.000 14.93002 ? 401 4WI A C15 1 
HETATM 2405 N N5  . 4WI B 2 .   ? -17.35886 20.71962 -30.59127 1.000 14.13089 ? 401 4WI A N5  1 
HETATM 2406 N N2  . 4WI B 2 .   ? -16.81608 22.30724 -24.44402 1.000 14.40260 ? 401 4WI A N2  1 
HETATM 2407 N N3  . 4WI B 2 .   ? -19.62720 16.23460 -25.72635 1.000 14.93171 ? 401 4WI A N3  1 
HETATM 2408 N N1  . 4WI B 2 .   ? -17.75131 18.35556 -27.81435 1.000 14.65496 ? 401 4WI A N1  1 
HETATM 2409 N N4  . 4WI B 2 .   ? -19.08053 15.88917 -22.37172 1.000 12.97423 ? 401 4WI A N4  1 
HETATM 2410 O O1  . 4WI B 2 .   ? -14.93456 21.24018 -25.20292 1.000 14.87352 ? 401 4WI A O1  1 
HETATM 2411 O O2  . 4WI B 2 .   ? -19.90146 18.57391 -27.23614 1.000 15.62570 ? 401 4WI A O2  1 
HETATM 2412 O O3  . 4WI B 2 .   ? -18.04421 17.37205 -24.62041 1.000 14.07014 ? 401 4WI A O3  1 
HETATM 2413 O O4  . 4WI B 2 .   ? -20.12450 13.91820 -22.59709 1.000 18.69028 ? 401 4WI A O4  1 
HETATM 2414 F F1  . 4WI B 2 .   ? -16.98401 14.37022 -21.56528 1.000 23.06407 ? 401 4WI A F1  1 
HETATM 2415 F F2  . 4WI B 2 .   ? -18.30749 12.68766 -21.22694 1.000 23.90480 ? 401 4WI A F2  1 
HETATM 2416 F F3  . 4WI B 2 .   ? -18.37856 14.42705 -19.91795 1.000 27.36983 ? 401 4WI A F3  1 
HETATM 2417 H H5  . 4WI B 2 .   ? -19.32920 21.00778 -25.98991 1.000 19.72597 ? 401 4WI A H5  1 
HETATM 2418 H H6  . 4WI B 2 .   ? -18.40206 22.32244 -26.78859 1.000 19.72597 ? 401 4WI A H6  1 
HETATM 2419 H H7  . 4WI B 2 .   ? -18.75871 21.74523 -23.84645 1.000 20.53046 ? 401 4WI A H7  1 
HETATM 2420 H H8  . 4WI B 2 .   ? -18.64655 23.32408 -24.69343 1.000 20.53046 ? 401 4WI A H8  1 
HETATM 2421 H H11 . 4WI B 2 .   ? -21.85150 15.81099 -25.66969 1.000 19.54366 ? 401 4WI A H11 1 
HETATM 2422 H H12 . 4WI B 2 .   ? -21.15264 14.63372 -25.23605 1.000 19.54366 ? 401 4WI A H12 1 
HETATM 2423 H H10 . 4WI B 2 .   ? -17.89513 15.94195 -26.91949 1.000 17.89641 ? 401 4WI A H10 1 
HETATM 2424 H H14 . 4WI B 2 .   ? -19.53475 15.64830 -29.13268 1.000 16.08557 ? 401 4WI A H14 1 
HETATM 2425 H H23 . 4WI B 2 .   ? -18.76088 12.68864 -29.06598 1.000 17.93026 ? 401 4WI A H23 1 
HETATM 2426 H H24 . 4WI B 2 .   ? -20.31318 12.19374 -28.36593 1.000 17.93026 ? 401 4WI A H24 1 
HETATM 2427 H H25 . 4WI B 2 .   ? -20.26144 13.47318 -29.59272 1.000 17.93026 ? 401 4WI A H25 1 
HETATM 2428 H H26 . 4WI B 2 .   ? -18.77164 12.47341 -26.51143 1.000 21.32695 ? 401 4WI A H26 1 
HETATM 2429 H H27 . 4WI B 2 .   ? -17.62328 13.78678 -26.88689 1.000 21.32695 ? 401 4WI A H27 1 
HETATM 2430 H H28 . 4WI B 2 .   ? -18.89177 14.03524 -25.65650 1.000 21.32695 ? 401 4WI A H28 1 
HETATM 2431 H H17 . 4WI B 2 .   ? -18.65846 19.06673 -23.23460 1.000 18.66158 ? 401 4WI A H17 1 
HETATM 2432 H H19 . 4WI B 2 .   ? -18.71105 18.45262 -21.56729 1.000 18.66158 ? 401 4WI A H19 1 
HETATM 2433 H H18 . 4WI B 2 .   ? -19.71860 19.84019 -22.03557 1.000 18.66158 ? 401 4WI A H18 1 
HETATM 2434 H H20 . 4WI B 2 .   ? -21.50910 18.52011 -20.98019 1.000 20.60414 ? 401 4WI A H20 1 
HETATM 2435 H H21 . 4WI B 2 .   ? -22.20560 17.12871 -21.83465 1.000 20.60414 ? 401 4WI A H21 1 
HETATM 2436 H H22 . 4WI B 2 .   ? -20.72644 16.93037 -20.87341 1.000 20.60414 ? 401 4WI A H22 1 
HETATM 2437 H H29 . 4WI B 2 .   ? -20.69028 19.15435 -24.51846 1.000 20.16000 ? 401 4WI A H29 1 
HETATM 2438 H H30 . 4WI B 2 .   ? -21.79979 17.76690 -24.41292 1.000 20.16000 ? 401 4WI A H30 1 
HETATM 2439 H H31 . 4WI B 2 .   ? -22.06372 19.19732 -23.38755 1.000 20.16000 ? 401 4WI A H31 1 
HETATM 2440 H H2  . 4WI B 2 .   ? -16.48434 21.49507 -27.88196 1.000 15.13323 ? 401 4WI A H2  1 
HETATM 2441 H H3  . 4WI B 2 .   ? -15.69757 19.98152 -27.37828 1.000 15.13323 ? 401 4WI A H3  1 
HETATM 2442 H H32 . 4WI B 2 .   ? -18.58451 20.21170 -28.22701 1.000 17.99737 ? 401 4WI A H32 1 
HETATM 2443 H H15 . 4WI B 2 .   ? -20.86630 16.07648 -23.48834 1.000 15.51408 ? 401 4WI A H15 1 
HETATM 2444 H H9  . 4WI B 2 .   ? -16.35736 22.92303 -23.79408 1.000 17.28431 ? 401 4WI A H9  1 
HETATM 2445 H H1  . 4WI B 2 .   ? -17.31215 17.71833 -28.45080 1.000 17.58714 ? 401 4WI A H1  1 
HETATM 2446 H H16 . 4WI B 2 .   ? -18.34091 16.39270 -21.91187 1.000 15.57028 ? 401 4WI A H16 1 
HETATM 2447 O O   . HOH C 3 .   ? -0.49537  13.88647 -46.95872 1.000 37.78698 ? 501 HOH A O   1 
HETATM 2448 O O   . HOH C 3 .   ? 3.70715   31.33679 0.61234   1.000 42.01700 ? 502 HOH A O   1 
HETATM 2449 O O   . HOH C 3 .   ? 3.90197   19.04899 4.35183   1.000 43.59221 ? 503 HOH A O   1 
HETATM 2450 O O   . HOH C 3 .   ? 6.47851   13.37440 -17.30085 1.000 29.07954 ? 504 HOH A O   1 
HETATM 2451 O O   . HOH C 3 .   ? 5.99291   12.64141 -28.04349 1.000 46.76301 ? 505 HOH A O   1 
HETATM 2452 O O   . HOH C 3 .   ? -11.39556 8.14955  -15.93814 1.000 37.12102 ? 506 HOH A O   1 
HETATM 2453 O O   . HOH C 3 .   ? 15.24955  21.49904 -35.56232 1.000 41.30193 ? 507 HOH A O   1 
HETATM 2454 O O   . HOH C 3 .   ? -14.44061 20.61016 -57.95403 1.000 41.30084 ? 508 HOH A O   1 
HETATM 2455 O O   . HOH C 3 .   ? -26.88127 9.32231  -50.37381 1.000 24.84634 ? 509 HOH A O   1 
HETATM 2456 O O   . HOH C 3 .   ? 16.44505  32.19011 -36.65494 1.000 36.00905 ? 510 HOH A O   1 
HETATM 2457 O O   . HOH C 3 .   ? 2.56845   10.83215 -13.76911 1.000 42.59214 ? 511 HOH A O   1 
HETATM 2458 O O   . HOH C 3 .   ? -13.51892 21.23976 -54.96183 1.000 34.36462 ? 512 HOH A O   1 
HETATM 2459 O O   . HOH C 3 .   ? -1.61540  11.08860 -8.28118  1.000 38.98762 ? 513 HOH A O   1 
HETATM 2460 O O   . HOH C 3 .   ? -27.89314 4.19601  -35.40189 1.000 31.30888 ? 514 HOH A O   1 
HETATM 2461 O O   . HOH C 3 .   ? -18.21520 20.10937 -49.65626 1.000 22.22348 ? 515 HOH A O   1 
HETATM 2462 O O   . HOH C 3 .   ? -2.56522  6.18319  -32.62782 1.000 25.47294 ? 516 HOH A O   1 
HETATM 2463 O O   . HOH C 3 .   ? 21.44933  15.14096 -20.94409 1.000 20.15143 ? 517 HOH A O   1 
HETATM 2464 O O   . HOH C 3 .   ? 0.46682   25.73008 -20.23905 1.000 21.92489 ? 518 HOH A O   1 
HETATM 2465 O O   . HOH C 3 .   ? 3.49499   22.08837 -6.24791  1.000 30.96393 ? 519 HOH A O   1 
HETATM 2466 O O   . HOH C 3 .   ? -18.35666 -0.12258 -33.44986 1.000 31.33692 ? 520 HOH A O   1 
HETATM 2467 O O   . HOH C 3 .   ? -13.10062 29.35289 -24.50373 1.000 20.38783 ? 521 HOH A O   1 
HETATM 2468 O O   . HOH C 3 .   ? 8.46512   14.01763 -13.85107 1.000 21.71563 ? 522 HOH A O   1 
HETATM 2469 O O   . HOH C 3 .   ? 3.91003   32.53871 -2.35067  1.000 24.38240 ? 523 HOH A O   1 
HETATM 2470 O O   . HOH C 3 .   ? 7.68987   9.72142  -6.20036  1.000 25.16499 ? 524 HOH A O   1 
HETATM 2471 O O   . HOH C 3 .   ? -26.66825 11.14929 -38.70639 1.000 29.74161 ? 525 HOH A O   1 
HETATM 2472 O O   . HOH C 3 .   ? -15.93939 2.46918  -33.86688 1.000 24.32680 ? 526 HOH A O   1 
HETATM 2473 O O   . HOH C 3 .   ? 3.31933   30.60382 -16.93554 1.000 30.36399 ? 527 HOH A O   1 
HETATM 2474 O O   . HOH C 3 .   ? 20.75194  24.72879 -22.01377 1.000 36.80577 ? 528 HOH A O   1 
HETATM 2475 O O   . HOH C 3 .   ? 17.94784  7.18973  -18.69452 1.000 21.42445 ? 529 HOH A O   1 
HETATM 2476 O O   . HOH C 3 .   ? -22.11424 22.09862 -24.51839 1.000 27.83100 ? 530 HOH A O   1 
HETATM 2477 O O   . HOH C 3 .   ? -11.04021 32.33711 -41.14747 1.000 37.25750 ? 531 HOH A O   1 
HETATM 2478 O O   . HOH C 3 .   ? 12.03016  19.17053 -41.11757 1.000 29.37447 ? 532 HOH A O   1 
HETATM 2479 O O   . HOH C 3 .   ? -19.18255 23.48363 -43.72086 1.000 19.80262 ? 533 HOH A O   1 
HETATM 2480 O O   . HOH C 3 .   ? -9.94005  29.85678 -41.56395 1.000 25.90379 ? 534 HOH A O   1 
HETATM 2481 O O   . HOH C 3 .   ? -7.90393  10.16756 -16.51845 1.000 19.92589 ? 535 HOH A O   1 
HETATM 2482 O O   . HOH C 3 .   ? 0.27368   9.28851  -16.79004 1.000 25.07201 ? 536 HOH A O   1 
HETATM 2483 O O   . HOH C 3 .   ? 0.92944   18.41372 -6.33723  1.000 30.11883 ? 537 HOH A O   1 
HETATM 2484 O O   . HOH C 3 .   ? 5.42239   10.58900 -19.74392 1.000 35.22145 ? 538 HOH A O   1 
HETATM 2485 O O   . HOH C 3 .   ? -29.01750 17.71900 -33.89080 1.000 35.63909 ? 539 HOH A O   1 
HETATM 2486 O O   . HOH C 3 .   ? 10.70375  22.30909 -31.65393 1.000 32.38399 ? 540 HOH A O   1 
HETATM 2487 O O   . HOH C 3 .   ? 11.53152  17.35996 -46.05575 1.000 39.06804 ? 541 HOH A O   1 
HETATM 2488 O O   . HOH C 3 .   ? 6.11333   38.62924 -7.43963  1.000 40.43313 ? 542 HOH A O   1 
HETATM 2489 O O   . HOH C 3 .   ? -11.85038 28.71988 -27.38650 1.000 16.34774 ? 543 HOH A O   1 
HETATM 2490 O O   . HOH C 3 .   ? 5.24973   25.22338 -22.59220 1.000 15.56679 ? 544 HOH A O   1 
HETATM 2491 O O   . HOH C 3 .   ? 8.67571   20.24430 -25.49163 1.000 25.47727 ? 545 HOH A O   1 
HETATM 2492 O O   . HOH C 3 .   ? 3.85376   12.95951 -16.99182 1.000 32.59845 ? 546 HOH A O   1 
HETATM 2493 O O   . HOH C 3 .   ? -0.46112  26.54709 -43.87380 1.000 19.72450 ? 547 HOH A O   1 
HETATM 2494 O O   . HOH C 3 .   ? -5.42164  26.82128 -48.47676 1.000 26.10818 ? 548 HOH A O   1 
HETATM 2495 O O   . HOH C 3 .   ? 7.33636   9.13009  -13.72241 1.000 23.73925 ? 549 HOH A O   1 
HETATM 2496 O O   . HOH C 3 .   ? -16.94437 20.92778 -17.72329 1.000 19.21436 ? 550 HOH A O   1 
HETATM 2497 O O   . HOH C 3 .   ? 22.97417  30.80126 -18.86153 1.000 26.57851 ? 551 HOH A O   1 
HETATM 2498 O O   . HOH C 3 .   ? -6.86858  24.06831 -34.87314 1.000 13.57544 ? 552 HOH A O   1 
HETATM 2499 O O   . HOH C 3 .   ? 19.57950  37.93861 -9.81435  1.000 25.21323 ? 553 HOH A O   1 
HETATM 2500 O O   . HOH C 3 .   ? -4.83801  10.10181 -44.78767 1.000 33.65180 ? 554 HOH A O   1 
HETATM 2501 O O   . HOH C 3 .   ? 10.42210  8.24941  -17.62481 1.000 23.17699 ? 555 HOH A O   1 
HETATM 2502 O O   . HOH C 3 .   ? -19.13791 5.78937  -21.25071 1.000 34.56243 ? 556 HOH A O   1 
HETATM 2503 O O   . HOH C 3 .   ? 20.11833  22.76580 -3.96746  1.000 22.44282 ? 557 HOH A O   1 
HETATM 2504 O O   . HOH C 3 .   ? 14.07012  35.65279 -22.09338 1.000 21.39102 ? 558 HOH A O   1 
HETATM 2505 O O   . HOH C 3 .   ? 12.54383  20.04139 -44.68815 1.000 31.12199 ? 559 HOH A O   1 
HETATM 2506 O O   . HOH C 3 .   ? -5.37256  9.58705  -39.76475 1.000 23.73343 ? 560 HOH A O   1 
HETATM 2507 O O   . HOH C 3 .   ? -2.58688  11.23407 -12.75918 1.000 33.60183 ? 561 HOH A O   1 
HETATM 2508 O O   . HOH C 3 .   ? -28.89005 10.51411 -37.43626 1.000 28.39934 ? 562 HOH A O   1 
HETATM 2509 O O   . HOH C 3 .   ? 22.16207  12.79886 -17.56937 1.000 24.26238 ? 563 HOH A O   1 
HETATM 2510 O O   . HOH C 3 .   ? -9.16576  23.92351 -18.47844 1.000 22.57845 ? 564 HOH A O   1 
HETATM 2511 O O   . HOH C 3 .   ? -20.51840 5.25761  -45.94630 1.000 26.11510 ? 565 HOH A O   1 
HETATM 2512 O O   . HOH C 3 .   ? -9.90416  5.53081  -24.80538 1.000 30.68465 ? 566 HOH A O   1 
HETATM 2513 O O   . HOH C 3 .   ? 3.89259   28.68004 0.45744   1.000 38.07048 ? 567 HOH A O   1 
HETATM 2514 O O   . HOH C 3 .   ? -19.52641 15.12683 -53.25082 1.000 26.46367 ? 568 HOH A O   1 
HETATM 2515 O O   . HOH C 3 .   ? -13.81861 3.63666  -35.99906 1.000 23.14584 ? 569 HOH A O   1 
HETATM 2516 O O   . HOH C 3 .   ? 5.69865   22.51809 -26.83527 1.000 21.83284 ? 570 HOH A O   1 
HETATM 2517 O O   . HOH C 3 .   ? 2.27776   11.13044 -5.77744  1.000 27.63857 ? 571 HOH A O   1 
HETATM 2518 O O   . HOH C 3 .   ? -12.11587 3.16648  -22.01440 1.000 35.53101 ? 572 HOH A O   1 
HETATM 2519 O O   . HOH C 3 .   ? -17.41413 24.91817 -35.50803 1.000 17.64423 ? 573 HOH A O   1 
HETATM 2520 O O   . HOH C 3 .   ? 19.03360  6.22033  -11.95973 1.000 26.71841 ? 574 HOH A O   1 
HETATM 2521 O O   . HOH C 3 .   ? -5.67875  18.55641 -14.30564 1.000 34.01823 ? 575 HOH A O   1 
HETATM 2522 O O   . HOH C 3 .   ? -14.90044 6.69489  -20.32085 1.000 32.30679 ? 576 HOH A O   1 
HETATM 2523 O O   . HOH C 3 .   ? -7.81895  14.23310 -54.57645 1.000 23.13320 ? 577 HOH A O   1 
HETATM 2524 O O   . HOH C 3 .   ? 23.84524  28.88698 -11.91424 1.000 19.15574 ? 578 HOH A O   1 
HETATM 2525 O O   . HOH C 3 .   ? 14.32324  25.49631 -1.53409  1.000 15.78680 ? 579 HOH A O   1 
HETATM 2526 O O   . HOH C 3 .   ? 2.72562   26.25154 -16.23356 1.000 22.55759 ? 580 HOH A O   1 
HETATM 2527 O O   . HOH C 3 .   ? 7.79655   18.62750 -35.97105 1.000 21.35629 ? 581 HOH A O   1 
HETATM 2528 O O   . HOH C 3 .   ? -15.86120 31.05315 -39.85903 1.000 36.28400 ? 582 HOH A O   1 
HETATM 2529 O O   . HOH C 3 .   ? -0.64979  15.46727 -1.82136  1.000 25.88483 ? 583 HOH A O   1 
HETATM 2530 O O   . HOH C 3 .   ? -3.33380  14.13153 -45.81189 1.000 20.50928 ? 584 HOH A O   1 
HETATM 2531 O O   . HOH C 3 .   ? -4.70524  7.97316  -43.32273 1.000 40.85307 ? 585 HOH A O   1 
HETATM 2532 O O   . HOH C 3 .   ? 6.54422   23.51120 -43.99220 1.000 20.10147 ? 586 HOH A O   1 
HETATM 2533 O O   . HOH C 3 .   ? -7.51554  17.09211 -15.36567 1.000 31.06347 ? 587 HOH A O   1 
HETATM 2534 O O   . HOH C 3 .   ? 21.63359  34.22110 -16.19835 1.000 19.98990 ? 588 HOH A O   1 
HETATM 2535 O O   . HOH C 3 .   ? -9.45147  4.00895  -30.68051 1.000 37.44403 ? 589 HOH A O   1 
HETATM 2536 O O   . HOH C 3 .   ? -14.47519 6.22071  -28.53676 1.000 20.20503 ? 590 HOH A O   1 
HETATM 2537 O O   . HOH C 3 .   ? -1.14016  19.81730 -50.90559 1.000 23.51807 ? 591 HOH A O   1 
HETATM 2538 O O   . HOH C 3 .   ? -19.49186 13.32762 -16.76732 1.000 25.17926 ? 592 HOH A O   1 
HETATM 2539 O O   . HOH C 3 .   ? -2.86164  21.32968 -19.80507 1.000 14.17835 ? 593 HOH A O   1 
HETATM 2540 O O   . HOH C 3 .   ? 3.87072   38.23416 -9.29750  1.000 32.49378 ? 594 HOH A O   1 
HETATM 2541 O O   . HOH C 3 .   ? 20.61649  31.71413 -4.41597  1.000 20.49286 ? 595 HOH A O   1 
HETATM 2542 O O   . HOH C 3 .   ? 2.47187   30.34460 -2.40088  1.000 32.45787 ? 596 HOH A O   1 
HETATM 2543 O O   . HOH C 3 .   ? 7.22647   14.83036 -42.44790 1.000 30.81941 ? 597 HOH A O   1 
HETATM 2544 O O   . HOH C 3 .   ? 25.44540  21.60951 -8.54230  1.000 19.60610 ? 598 HOH A O   1 
HETATM 2545 O O   . HOH C 3 .   ? 13.18128  24.89631 -34.91313 1.000 30.71673 ? 599 HOH A O   1 
HETATM 2546 O O   . HOH C 3 .   ? -4.31208  11.28337 -53.62095 1.000 34.00326 ? 600 HOH A O   1 
HETATM 2547 O O   . HOH C 3 .   ? 5.07352   9.71570  -6.95375  1.000 20.17344 ? 601 HOH A O   1 
HETATM 2548 O O   . HOH C 3 .   ? 17.46384  20.35847 -20.39919 1.000 15.26962 ? 602 HOH A O   1 
HETATM 2549 O O   . HOH C 3 .   ? 21.649    7.694    -18.333   1.000 21.80966 ? 603 HOH A O   1 
HETATM 2550 O O   . HOH C 3 .   ? -19.87223 3.17322  -32.86698 1.000 21.99597 ? 604 HOH A O   1 
HETATM 2551 O O   . HOH C 3 .   ? -1.27814  12.14089 -34.25070 1.000 16.77715 ? 605 HOH A O   1 
HETATM 2552 O O   . HOH C 3 .   ? 2.875     15.231   6.610     1.000 42.04643 ? 606 HOH A O   1 
HETATM 2553 O O   . HOH C 3 .   ? 8.05142   16.69492 -19.89437 1.000 21.04253 ? 607 HOH A O   1 
HETATM 2554 O O   . HOH C 3 .   ? 11.11662  8.35537  -20.67330 1.000 37.56095 ? 608 HOH A O   1 
HETATM 2555 O O   . HOH C 3 .   ? -9.07218  5.06186  -43.42739 1.000 31.91695 ? 609 HOH A O   1 
HETATM 2556 O O   . HOH C 3 .   ? 19.33108  11.90865 0.25917   1.000 32.12474 ? 610 HOH A O   1 
HETATM 2557 O O   . HOH C 3 .   ? -10.618   35.508   -29.982   1.000 27.81726 ? 611 HOH A O   1 
HETATM 2558 O O   . HOH C 3 .   ? 7.11885   23.88820 -15.87460 1.000 11.52320 ? 612 HOH A O   1 
HETATM 2559 O O   . HOH C 3 .   ? 16.59670  19.59840 0.61408   1.000 23.03142 ? 613 HOH A O   1 
HETATM 2560 O O   . HOH C 3 .   ? -25.91663 8.97274  -22.02679 1.000 22.34874 ? 614 HOH A O   1 
HETATM 2561 O O   . HOH C 3 .   ? 21.31414  15.13721 -16.44407 1.000 25.28085 ? 615 HOH A O   1 
HETATM 2562 O O   . HOH C 3 .   ? -7.78248  13.10322 -23.95736 1.000 16.80446 ? 616 HOH A O   1 
HETATM 2563 O O   . HOH C 3 .   ? 25.56526  19.05657 -14.88403 1.000 25.53325 ? 617 HOH A O   1 
HETATM 2564 O O   . HOH C 3 .   ? 11.34175  36.23000 -6.35006  1.000 20.94048 ? 618 HOH A O   1 
HETATM 2565 O O   . HOH C 3 .   ? 19.52959  26.44837 -28.34989 1.000 36.19684 ? 619 HOH A O   1 
HETATM 2566 O O   . HOH C 3 .   ? 2.22268   18.58778 -50.19528 1.000 37.85754 ? 620 HOH A O   1 
HETATM 2567 O O   . HOH C 3 .   ? 1.93029   32.47182 -14.18163 1.000 45.82694 ? 621 HOH A O   1 
HETATM 2568 O O   . HOH C 3 .   ? -25.10153 15.34874 -38.25783 1.000 27.60640 ? 622 HOH A O   1 
HETATM 2569 O O   . HOH C 3 .   ? -15.88709 12.26589 -32.12708 1.000 17.03351 ? 623 HOH A O   1 
HETATM 2570 O O   . HOH C 3 .   ? 18.00704  25.34370 3.42641   1.000 28.99651 ? 624 HOH A O   1 
HETATM 2571 O O   . HOH C 3 .   ? -19.56753 2.71243  -41.50953 1.000 24.92550 ? 625 HOH A O   1 
HETATM 2572 O O   . HOH C 3 .   ? -13.44783 14.79339 -14.73277 1.000 26.92778 ? 626 HOH A O   1 
HETATM 2573 O O   . HOH C 3 .   ? -26.38769 16.12084 -27.42255 1.000 25.29563 ? 627 HOH A O   1 
HETATM 2574 O O   . HOH C 3 .   ? -1.57187  31.06050 -42.51667 1.000 40.83183 ? 628 HOH A O   1 
HETATM 2575 O O   . HOH C 3 .   ? -24.56511 24.04996 -38.62901 1.000 37.92275 ? 629 HOH A O   1 
HETATM 2576 O O   . HOH C 3 .   ? 27.44845  28.32923 -18.63969 1.000 27.27184 ? 630 HOH A O   1 
HETATM 2577 O O   . HOH C 3 .   ? 21.87691  33.07401 -13.61814 1.000 19.49080 ? 631 HOH A O   1 
HETATM 2578 O O   . HOH C 3 .   ? 12.36193  26.92625 3.58981   1.000 33.88625 ? 632 HOH A O   1 
HETATM 2579 O O   . HOH C 3 .   ? 9.27225   36.27606 -8.92553  1.000 19.18149 ? 633 HOH A O   1 
HETATM 2580 O O   . HOH C 3 .   ? 23.01871  12.33784 -4.18434  1.000 26.64415 ? 634 HOH A O   1 
HETATM 2581 O O   . HOH C 3 .   ? -28.11924 8.30011  -28.53802 1.000 28.90274 ? 635 HOH A O   1 
HETATM 2582 O O   . HOH C 3 .   ? 15.55847  35.59179 -6.28092  1.000 28.63128 ? 636 HOH A O   1 
HETATM 2583 O O   . HOH C 3 .   ? 18.21646  33.36503 -21.87997 1.000 26.14714 ? 637 HOH A O   1 
HETATM 2584 O O   . HOH C 3 .   ? -28.044   11.945   -49.274   1.000 25.52855 ? 638 HOH A O   1 
HETATM 2585 O O   . HOH C 3 .   ? 16.30972  17.67617 -23.26374 1.000 25.63733 ? 639 HOH A O   1 
HETATM 2586 O O   . HOH C 3 .   ? 3.43818   17.28554 -31.36542 1.000 20.18786 ? 640 HOH A O   1 
HETATM 2587 O O   . HOH C 3 .   ? -7.44547  29.91097 -40.58464 1.000 30.26418 ? 641 HOH A O   1 
HETATM 2588 O O   . HOH C 3 .   ? 14.82269  5.75297  -13.19459 1.000 28.04819 ? 642 HOH A O   1 
HETATM 2589 O O   . HOH C 3 .   ? 2.64404   28.09515 -2.99840  1.000 40.98170 ? 643 HOH A O   1 
HETATM 2590 O O   . HOH C 3 .   ? 8.31435   20.59541 -28.78541 1.000 38.94539 ? 644 HOH A O   1 
HETATM 2591 O O   . HOH C 3 .   ? 28.19958  23.01181 -15.88882 1.000 20.70586 ? 645 HOH A O   1 
HETATM 2592 O O   . HOH C 3 .   ? -17.89470 5.73848  -28.90150 1.000 34.71335 ? 646 HOH A O   1 
HETATM 2593 O O   . HOH C 3 .   ? 20.51284  9.07516  -6.59374  1.000 20.83469 ? 647 HOH A O   1 
HETATM 2594 O O   . HOH C 3 .   ? -16.17214 14.72580 -58.27441 1.000 26.79553 ? 648 HOH A O   1 
HETATM 2595 O O   . HOH C 3 .   ? 6.48418   18.78905 -25.87872 1.000 26.63658 ? 649 HOH A O   1 
HETATM 2596 O O   . HOH C 3 .   ? -6.25019  32.48839 -40.27598 1.000 26.66457 ? 650 HOH A O   1 
HETATM 2597 O O   . HOH C 3 .   ? 3.33084   11.08190 -39.69878 1.000 26.22172 ? 651 HOH A O   1 
HETATM 2598 O O   . HOH C 3 .   ? 11.05222  28.07494 1.28867   1.000 26.43887 ? 652 HOH A O   1 
HETATM 2599 O O   . HOH C 3 .   ? -20.20537 21.48307 -30.13511 1.000 25.09748 ? 653 HOH A O   1 
HETATM 2600 O O   . HOH C 3 .   ? 6.02159   27.82613 -23.51842 1.000 17.12765 ? 654 HOH A O   1 
HETATM 2601 O O   . HOH C 3 .   ? 18.57712  38.02674 -22.34062 1.000 17.93441 ? 655 HOH A O   1 
HETATM 2602 O O   . HOH C 3 .   ? -3.47236  35.34223 -38.16515 1.000 17.37169 ? 656 HOH A O   1 
HETATM 2603 O O   . HOH C 3 .   ? 19.79943  10.41399 -11.06133 1.000 22.35227 ? 657 HOH A O   1 
HETATM 2604 O O   . HOH C 3 .   ? -18.95499 23.60858 -21.31090 1.000 17.73091 ? 658 HOH A O   1 
HETATM 2605 O O   . HOH C 3 .   ? -2.88269  5.83414  -40.11725 1.000 42.75797 ? 659 HOH A O   1 
HETATM 2606 O O   . HOH C 3 .   ? -0.35439  22.16103 -12.66101 1.000 34.51029 ? 660 HOH A O   1 
HETATM 2607 O O   . HOH C 3 .   ? -27.14893 -0.19474 -41.33635 1.000 37.71588 ? 661 HOH A O   1 
HETATM 2608 O O   . HOH C 3 .   ? -9.97591  5.84560  -29.02831 1.000 17.54181 ? 662 HOH A O   1 
HETATM 2609 O O   . HOH C 3 .   ? 18.06942  33.11501 -32.00095 1.000 41.96008 ? 663 HOH A O   1 
HETATM 2610 O O   . HOH C 3 .   ? 13.17031  15.53494 -42.15590 1.000 48.05610 ? 664 HOH A O   1 
HETATM 2611 O O   . HOH C 3 .   ? -23.14396 22.00553 -34.78819 1.000 32.65259 ? 665 HOH A O   1 
HETATM 2612 O O   . HOH C 3 .   ? -8.98705  16.14637 -58.58163 1.000 31.22947 ? 666 HOH A O   1 
HETATM 2613 O O   . HOH C 3 .   ? 0.52108   8.74025  -24.71549 1.000 32.02017 ? 667 HOH A O   1 
HETATM 2614 O O   . HOH C 3 .   ? -18.39762 17.25627 -18.70564 1.000 24.21599 ? 668 HOH A O   1 
HETATM 2615 O O   . HOH C 3 .   ? 16.73304  5.31916  -21.63612 1.000 40.68120 ? 669 HOH A O   1 
HETATM 2616 O O   . HOH C 3 .   ? -14.96689 3.71407  -42.96072 1.000 25.04271 ? 670 HOH A O   1 
HETATM 2617 O O   . HOH C 3 .   ? -17.42251 3.36725  -31.14491 1.000 31.99562 ? 671 HOH A O   1 
HETATM 2618 O O   . HOH C 3 .   ? 24.03364  22.84600 -22.14349 1.000 17.36532 ? 672 HOH A O   1 
HETATM 2619 O O   . HOH C 3 .   ? 4.06542   9.00501  -32.48269 1.000 28.91186 ? 673 HOH A O   1 
HETATM 2620 O O   . HOH C 3 .   ? -21.97923 13.65925 -19.80913 1.000 24.60866 ? 674 HOH A O   1 
HETATM 2621 O O   . HOH C 3 .   ? 11.75962  18.43021 -23.08725 1.000 18.63952 ? 675 HOH A O   1 
HETATM 2622 O O   . HOH C 3 .   ? 12.96699  6.30775  -7.00738  1.000 32.12657 ? 676 HOH A O   1 
HETATM 2623 O O   . HOH C 3 .   ? 20.07710  33.23462 -25.77626 1.000 40.18760 ? 677 HOH A O   1 
HETATM 2624 O O   . HOH C 3 .   ? -23.23323 20.73068 -51.10803 1.000 36.29660 ? 678 HOH A O   1 
HETATM 2625 O O   . HOH C 3 .   ? 6.35892   31.58387 -14.01849 1.000 24.37069 ? 679 HOH A O   1 
HETATM 2626 O O   . HOH C 3 .   ? 3.61498   21.75990 -0.70446  1.000 25.72178 ? 680 HOH A O   1 
HETATM 2627 O O   . HOH C 3 .   ? -26.56966 9.24570  -40.48239 1.000 37.42147 ? 681 HOH A O   1 
HETATM 2628 O O   . HOH C 3 .   ? -12.05894 5.58405  -27.34557 1.000 20.80533 ? 682 HOH A O   1 
HETATM 2629 O O   . HOH C 3 .   ? -11.03594 8.67063  -46.86011 1.000 31.53104 ? 683 HOH A O   1 
HETATM 2630 O O   . HOH C 3 .   ? -22.374   11.376   -52.627   1.000 23.02543 ? 684 HOH A O   1 
HETATM 2631 O O   . HOH C 3 .   ? 8.79914   28.07720 -23.73940 1.000 16.70635 ? 685 HOH A O   1 
HETATM 2632 O O   . HOH C 3 .   ? -11.78636 27.72706 -43.36818 1.000 28.42007 ? 686 HOH A O   1 
HETATM 2633 O O   . HOH C 3 .   ? 2.90775   25.04563 -5.77232  1.000 24.87072 ? 687 HOH A O   1 
HETATM 2634 O O   . HOH C 3 .   ? 22.38956  14.99282 -10.49811 1.000 19.28822 ? 688 HOH A O   1 
HETATM 2635 O O   . HOH C 3 .   ? 23.12958  16.38293 -12.90319 1.000 23.43298 ? 689 HOH A O   1 
HETATM 2636 O O   . HOH C 3 .   ? -4.07442  11.09979 -49.77511 1.000 50.12841 ? 690 HOH A O   1 
HETATM 2637 O O   . HOH C 3 .   ? -3.80613  6.73222  -23.45713 1.000 25.26019 ? 691 HOH A O   1 
HETATM 2638 O O   . HOH C 3 .   ? 9.33574   37.47531 -16.88857 1.000 28.51937 ? 692 HOH A O   1 
HETATM 2639 O O   . HOH C 3 .   ? -27.21471 16.99036 -37.86249 1.000 34.43237 ? 693 HOH A O   1 
HETATM 2640 O O   . HOH C 3 .   ? -19.93035 26.16262 -24.79970 1.000 20.87898 ? 694 HOH A O   1 
HETATM 2641 O O   . HOH C 3 .   ? -24.54404 23.96722 -24.58428 1.000 29.05633 ? 695 HOH A O   1 
HETATM 2642 O O   . HOH C 3 .   ? 7.03342   19.61820 6.31536   1.000 39.22148 ? 696 HOH A O   1 
HETATM 2643 O O   . HOH C 3 .   ? -27.01821 14.24067 -39.67907 1.000 35.06896 ? 697 HOH A O   1 
HETATM 2644 O O   . HOH C 3 .   ? 20.54428  25.94100 2.44680   1.000 23.69362 ? 698 HOH A O   1 
HETATM 2645 O O   . HOH C 3 .   ? -6.84814  16.12532 -9.90359  1.000 39.65361 ? 699 HOH A O   1 
HETATM 2646 O O   . HOH C 3 .   ? -13.82871 29.22558 -42.20160 1.000 28.85730 ? 700 HOH A O   1 
HETATM 2647 O O   . HOH C 3 .   ? -3.17014  33.10516 -41.62206 1.000 34.24775 ? 701 HOH A O   1 
HETATM 2648 O O   . HOH C 3 .   ? 18.86069  7.08659  -5.43589  1.000 24.08327 ? 702 HOH A O   1 
HETATM 2649 O O   . HOH C 3 .   ? -22.89550 18.64690 -27.60417 1.000 39.35979 ? 703 HOH A O   1 
HETATM 2650 O O   . HOH C 3 .   ? -9.93396  27.98096 -50.14217 1.000 44.78437 ? 704 HOH A O   1 
HETATM 2651 O O   . HOH C 3 .   ? -16.83093 6.43409  -16.98010 1.000 44.63948 ? 705 HOH A O   1 
HETATM 2652 O O   . HOH C 3 .   ? 5.04961   28.73933 3.26377   1.000 45.62197 ? 706 HOH A O   1 
HETATM 2653 O O   . HOH C 3 .   ? 13.28412  27.26434 0.08239   1.000 25.53005 ? 707 HOH A O   1 
HETATM 2654 O O   . HOH C 3 .   ? -16.60141 7.28019  -52.53192 1.000 39.36994 ? 708 HOH A O   1 
HETATM 2655 O O   . HOH C 3 .   ? 1.27325   24.71787 -13.98381 1.000 26.09388 ? 709 HOH A O   1 
HETATM 2656 O O   . HOH C 3 .   ? 13.59738  38.23770 -15.72744 1.000 26.97185 ? 710 HOH A O   1 
HETATM 2657 O O   . HOH C 3 .   ? -20.17466 8.18054  -51.24321 1.000 26.58978 ? 711 HOH A O   1 
HETATM 2658 O O   . HOH C 3 .   ? 16.71561  28.31634 -34.31782 1.000 31.54244 ? 712 HOH A O   1 
HETATM 2659 O O   . HOH C 3 .   ? -11.12149 2.13981  -37.44987 1.000 35.22999 ? 713 HOH A O   1 
HETATM 2660 O O   . HOH C 3 .   ? -7.51177  26.57581 -45.45710 1.000 37.18718 ? 714 HOH A O   1 
HETATM 2661 O O   . HOH C 3 .   ? 1.84875   23.04607 -8.47720  1.000 40.87218 ? 715 HOH A O   1 
HETATM 2662 O O   . HOH C 3 .   ? -19.61776 19.91462 -54.43330 1.000 29.20136 ? 716 HOH A O   1 
HETATM 2663 O O   . HOH C 3 .   ? -4.96918  2.61428  -35.04006 1.000 32.89577 ? 717 HOH A O   1 
HETATM 2664 O O   . HOH C 3 .   ? 14.14649  6.01756  -16.90857 1.000 23.82863 ? 718 HOH A O   1 
HETATM 2665 O O   . HOH C 3 .   ? 24.556    17.942   -17.356   1.000 33.46942 ? 719 HOH A O   1 
HETATM 2666 O O   . HOH C 3 .   ? -13.91513 16.12934 -58.80340 1.000 28.19535 ? 720 HOH A O   1 
HETATM 2667 O O   . HOH C 3 .   ? 23.814    22.121   -3.741    1.000 37.64751 ? 721 HOH A O   1 
HETATM 2668 O O   . HOH C 3 .   ? -19.82765 28.72269 -29.07463 1.000 39.27477 ? 722 HOH A O   1 
HETATM 2669 O O   . HOH C 3 .   ? 13.05210  23.13517 -32.88544 1.000 32.28022 ? 723 HOH A O   1 
HETATM 2670 O O   . HOH C 3 .   ? -15.08082 28.15575 -43.79032 1.000 34.80109 ? 724 HOH A O   1 
HETATM 2671 O O   . HOH C 3 .   ? 12.151    32.893   -27.585   1.000 25.43899 ? 725 HOH A O   1 
HETATM 2672 O O   . HOH C 3 .   ? -19.09976 17.75480 -52.39106 1.000 30.87150 ? 726 HOH A O   1 
HETATM 2673 O O   . HOH C 3 .   ? 7.76353   15.71667 3.44949   1.000 33.25285 ? 727 HOH A O   1 
HETATM 2674 O O   . HOH C 3 .   ? -16.71676 4.59291  -48.23293 1.000 46.01050 ? 728 HOH A O   1 
HETATM 2675 O O   . HOH C 3 .   ? 17.80900  17.21460 0.70786   1.000 35.25479 ? 729 HOH A O   1 
HETATM 2676 O O   . HOH C 3 .   ? -15.74694 6.44611  -49.87918 1.000 38.85526 ? 730 HOH A O   1 
HETATM 2677 O O   . HOH C 3 .   ? -22.43075 25.45255 -43.03676 1.000 35.37972 ? 731 HOH A O   1 
HETATM 2678 O O   . HOH C 3 .   ? 15.57711  39.31867 -15.25079 1.000 30.44722 ? 732 HOH A O   1 
HETATM 2679 O O   . HOH C 3 .   ? -14.90760 7.65433  -16.76128 1.000 27.92106 ? 733 HOH A O   1 
HETATM 2680 O O   . HOH C 3 .   ? 17.79633  35.97639 -6.50207  1.000 25.99896 ? 734 HOH A O   1 
HETATM 2681 O O   . HOH C 3 .   ? -5.71326  2.79420  -37.13579 1.000 35.01135 ? 735 HOH A O   1 
HETATM 2682 O O   . HOH C 3 .   ? 22.41488  11.24214 -13.37902 1.000 22.37760 ? 736 HOH A O   1 
HETATM 2683 O O   . HOH C 3 .   ? -26.20783 6.60926  -22.92619 1.000 43.62104 ? 737 HOH A O   1 
HETATM 2684 O O   . HOH C 3 .   ? 8.06751   36.81104 -14.70770 1.000 42.88164 ? 738 HOH A O   1 
HETATM 2685 O O   . HOH C 3 .   ? 25.56509  24.20790 -8.08706  1.000 37.43970 ? 739 HOH A O   1 
HETATM 2686 O O   . HOH C 3 .   ? 18.06025  5.40521  -7.56104  1.000 36.26509 ? 740 HOH A O   1 
HETATM 2687 O O   . HOH C 3 .   ? 4.847     16.166   -45.141   1.000 21.67082 ? 741 HOH A O   1 
HETATM 2688 O O   . HOH C 3 .   ? 10.08338  17.20231 -37.01103 1.000 32.21435 ? 742 HOH A O   1 
HETATM 2689 O O   . HOH C 3 .   ? -11.303   25.072   -15.948   1.000 33.58909 ? 743 HOH A O   1 
HETATM 2690 O O   . HOH C 3 .   ? -18.951   11.495   -55.190   1.000 42.01233 ? 744 HOH A O   1 
HETATM 2691 O O   . HOH C 3 .   ? -13.52378 2.18231  -38.40885 1.000 39.33668 ? 745 HOH A O   1 
HETATM 2692 O O   . HOH C 3 .   ? -27.06108 17.77538 -25.29724 1.000 25.90645 ? 746 HOH A O   1 
HETATM 2693 O O   . HOH C 3 .   ? 5.526     29.512   -42.246   1.000 35.11858 ? 747 HOH A O   1 
HETATM 2694 O O   . HOH C 3 .   ? 11.43989  6.51073  -10.48791 1.000 36.35136 ? 748 HOH A O   1 
HETATM 2695 O O   . HOH C 3 .   ? 3.660     13.786   -44.588   1.000 41.71299 ? 749 HOH A O   1 
HETATM 2696 O O   . HOH C 3 .   ? 26.283    24.212   7.037     1.000 39.09197 ? 750 HOH A O   1 
HETATM 2697 O O   . HOH C 3 .   ? -21.97955 25.60395 -23.52746 1.000 31.38859 ? 751 HOH A O   1 
HETATM 2698 O O   . HOH C 3 .   ? 9.50974   17.93239 -24.71872 1.000 51.91411 ? 752 HOH A O   1 
HETATM 2699 O O   . HOH C 3 .   ? 16.16165  34.14585 -20.52515 1.000 25.60858 ? 753 HOH A O   1 
HETATM 2700 O O   . HOH C 3 .   ? 0.04049   29.01873 -44.34365 1.000 30.24346 ? 754 HOH A O   1 
HETATM 2701 O O   . HOH C 3 .   ? 16.55016  20.70934 -23.17490 1.000 26.34574 ? 755 HOH A O   1 
HETATM 2702 O O   . HOH C 3 .   ? 7.39363   13.73954 2.42992   1.000 37.20665 ? 756 HOH A O   1 
HETATM 2703 O O   . HOH C 3 .   ? 10.22235  13.79134 -22.82064 1.000 38.93083 ? 757 HOH A O   1 
HETATM 2704 O O   . HOH C 3 .   ? -13.54706 5.70741  -49.94150 1.000 39.49463 ? 758 HOH A O   1 
HETATM 2705 O O   . HOH C 3 .   ? 11.60484  5.65903  -17.41415 1.000 28.19181 ? 759 HOH A O   1 
HETATM 2706 O O   . HOH C 3 .   ? -16.93087 4.68747  -44.62644 1.000 33.79339 ? 760 HOH A O   1 
HETATM 2707 O O   . HOH C 3 .   ? 19.22786  34.69981 -4.21515  1.000 31.38874 ? 761 HOH A O   1 
HETATM 2708 O O   . HOH C 3 .   ? 15.13101  19.99338 2.71790   1.000 36.28383 ? 762 HOH A O   1 
HETATM 2709 O O   . HOH C 3 .   ? 23.13570  16.26012 -15.52895 1.000 30.82491 ? 763 HOH A O   1 
HETATM 2710 O O   . HOH C 3 .   ? 2.52177   10.24636 -16.67659 1.000 29.87970 ? 764 HOH A O   1 
HETATM 2711 O O   . HOH C 3 .   ? -16.27727 3.97840  -28.60085 1.000 45.86780 ? 765 HOH A O   1 
HETATM 2712 O O   . HOH C 3 .   ? 7.86935   8.34109  -16.41067 1.000 33.07183 ? 766 HOH A O   1 
HETATM 2713 O O   . HOH C 3 .   ? 22.300    14.213   1.560     1.000 35.28422 ? 767 HOH A O   1 
HETATM 2714 O O   . HOH C 3 .   ? -3.23080  8.61439  -40.92355 1.000 29.49440 ? 768 HOH A O   1 
HETATM 2715 O O   . HOH C 3 .   ? 10.53109  5.70876  -7.92844  1.000 31.32874 ? 769 HOH A O   1 
HETATM 2716 O O   . HOH C 3 .   ? -17.83382 21.63316 -54.83349 1.000 39.30361 ? 770 HOH A O   1 
HETATM 2717 O O   . HOH C 3 .   ? 8.09261   14.08978 -19.53752 1.000 35.27191 ? 771 HOH A O   1 
HETATM 2718 O O   . HOH C 3 .   ? 23.36818  8.55627  -12.99884 1.000 39.58064 ? 772 HOH A O   1 
HETATM 2719 O O   . HOH C 3 .   ? -30.35283 6.22289  -35.12477 1.000 44.35346 ? 773 HOH A O   1 
HETATM 2720 O O   . HOH C 3 .   ? -10.65861 3.09109  -23.78350 1.000 45.65045 ? 774 HOH A O   1 
HETATM 2721 O O   . HOH C 3 .   ? -19.38669 3.55162  -44.19213 1.000 24.49692 ? 775 HOH A O   1 
HETATM 2722 O O   . HOH C 3 .   ? 5.99519   16.45960 -31.27296 1.000 33.84068 ? 776 HOH A O   1 
HETATM 2723 O O   . HOH C 3 .   ? 3.40138   23.81088 2.44619   1.000 42.79646 ? 777 HOH A O   1 
HETATM 2724 O O   . HOH C 3 .   ? 9.32328   6.25583  -3.96512  1.000 27.77640 ? 778 HOH A O   1 
HETATM 2725 O O   . HOH C 3 .   ? -25.586   22.240   -25.861   1.000 37.18215 ? 779 HOH A O   1 
HETATM 2726 O O   . HOH C 3 .   ? 23.20882  12.28781 -1.31046  1.000 36.22171 ? 780 HOH A O   1 
HETATM 2727 O O   . HOH C 3 .   ? 3.20612   7.69189  -34.07156 1.000 44.97241 ? 781 HOH A O   1 
HETATM 2728 O O   . HOH C 3 .   ? 15.58737  23.95351 -36.35996 1.000 46.36452 ? 782 HOH A O   1 
HETATM 2729 O O   . HOH C 3 .   ? 20.48230  6.09353  -3.48536  1.000 38.52873 ? 783 HOH A O   1 
HETATM 2730 O O   . HOH C 3 .   ? -29.60354 6.98504  -26.80973 1.000 41.10595 ? 784 HOH A O   1 
HETATM 2731 O O   . HOH C 3 .   ? 7.39921   14.86777 -44.77122 1.000 34.93403 ? 785 HOH A O   1 
HETATM 2732 O O   . HOH C 3 .   ? 25.90339  17.28539 -12.85213 1.000 36.79049 ? 786 HOH A O   1 
HETATM 2733 O O   . HOH C 3 .   ? -6.36947  7.86976  -16.08519 1.000 35.78998 ? 787 HOH A O   1 
HETATM 2734 O O   . HOH C 3 .   ? -6.23669  35.97767 -38.56524 1.000 30.11028 ? 788 HOH A O   1 
HETATM 2735 O O   . HOH C 3 .   ? -5.617    24.939   -55.332   1.000 37.06527 ? 789 HOH A O   1 
HETATM 2736 O O   . HOH C 3 .   ? 2.66763   20.71402 -3.18229  1.000 36.45956 ? 790 HOH A O   1 
HETATM 2737 O O   . HOH C 3 .   ? 20.88461  8.85240  -9.18597  1.000 22.11569 ? 791 HOH A O   1 
HETATM 2738 O O   . HOH C 3 .   ? -3.922    13.876   -3.504    1.000 35.29051 ? 792 HOH A O   1 
HETATM 2739 O O   . HOH C 3 .   ? -20.45243 15.43243 -18.33644 1.000 26.38120 ? 793 HOH A O   1 
HETATM 2740 O O   . HOH C 3 .   ? -16.80573 5.06225  -20.46179 1.000 33.04904 ? 794 HOH A O   1 
HETATM 2741 O O   . HOH C 3 .   ? 8.29464   6.81546  -6.59980  1.000 27.32525 ? 795 HOH A O   1 
HETATM 2742 O O   . HOH C 3 .   ? 22.99184  10.09335 -5.50207  1.000 28.26572 ? 796 HOH A O   1 
HETATM 2743 O O   . HOH C 3 .   ? 9.55851   16.51555 -22.30971 1.000 33.19443 ? 797 HOH A O   1 
HETATM 2744 O O   . HOH C 3 .   ? -13.45532 2.32129  -44.36124 1.000 41.17279 ? 798 HOH A O   1 
HETATM 2745 O O   . HOH C 3 .   ? 0.04011   24.15628 -7.30959  1.000 35.76595 ? 799 HOH A O   1 
HETATM 2746 O O   . HOH C 3 .   ? 13.98513  17.03111 -24.34247 1.000 26.49764 ? 800 HOH A O   1 
HETATM 2747 O O   . HOH C 3 .   ? -12.09829 2.99655  -26.71594 1.000 36.18989 ? 801 HOH A O   1 
HETATM 2748 O O   . HOH C 3 .   ? -8.11417  13.07559 -56.96612 1.000 36.06746 ? 802 HOH A O   1 
HETATM 2749 O O   . HOH C 3 .   ? 7.13533   6.32087  -12.91950 1.000 37.38112 ? 803 HOH A O   1 
HETATM 2750 O O   . HOH C 3 .   ? -28.51710 0.39218  -43.49072 1.000 41.78204 ? 804 HOH A O   1 
HETATM 2751 O O   . HOH C 3 .   ? 23.699    12.968   -15.214   1.000 39.98428 ? 805 HOH A O   1 
HETATM 2752 O O   . HOH C 3 .   ? -16.282   2.183    -40.688   1.000 39.41949 ? 806 HOH A O   1 
HETATM 2753 O O   . HOH C 3 .   ? 24.63609  14.80544 -9.01111  1.000 29.38998 ? 807 HOH A O   1 
HETATM 2754 O O   . HOH C 3 .   ? 19.88105  5.91759  -9.15404  1.000 42.97252 ? 808 HOH A O   1 
HETATM 2755 O O   . HOH C 3 .   ? 21.93180  12.34885 -11.19174 1.000 21.69302 ? 809 HOH A O   1 
HETATM 2756 O O   . HOH C 3 .   ? -29.19230 8.11505  -40.14670 1.000 46.85849 ? 810 HOH A O   1 
HETATM 2757 O O   . HOH C 3 .   ? 1.12967   6.99857  -18.60003 1.000 38.47563 ? 811 HOH A O   1 
HETATM 2758 O O   . HOH C 3 .   ? 23.77022  8.45864  -10.13909 1.000 41.04218 ? 812 HOH A O   1 
HETATM 2759 O O   . HOH C 3 .   ? 18.02828  20.76938 -25.40769 1.000 32.76362 ? 813 HOH A O   1 
HETATM 2760 O O   . HOH C 3 .   ? 6.32577   5.30582  -7.33049  1.000 39.62401 ? 814 HOH A O   1 
# 
