data_9BO6
# 
_entry.id   9BO6 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BO6         pdb_00009bo6 10.2210/pdb9bo6/pdb 
WWPDB D_1000282934 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-02-12 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BO6 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-03 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              karen.anderson@yale.edu 
_pdbx_contact_author.name_first         Karen 
_pdbx_contact_author.name_last          Anderson 
_pdbx_contact_author.name_mi            S 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-3433-0780 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Papini, C.'     1 0000-0002-6098-4959 
'Kenneson, J.'   2 ?                   
'Anderson, K.S.' 3 0000-0003-3433-0780 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Acs Bio Med Chem Au' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2694-2437 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Exploring Possible Drug-Resistant Variants of SARS-CoV-2 Main Protease (Mpro) with Noncovalent Preclinical Candidate, Mpro61' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acsbiomedchemau.4c00109 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Kenneson, J.R.'  1 ? 
primary 'Papini, C.'      2 ? 
primary 'Tang, S.'        3 ? 
primary 'Huynh, K.'       4 ? 
primary 'Zhang, C.H.'     5 ? 
primary 'Jorgensen, W.L.' 6 ? 
primary 'Anderson, K.S.'  7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '3C-like proteinase nsp5' 33887.613 1   3.4.22.69 A173V,L50F ? ? 
2 non-polymer syn 
;(1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide
;
501.542   1   ?         ?          ? ? 
3 water       nat water 18.015    213 ?         ?          ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMFNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHVGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMFNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHVGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 
;(1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide
;
4WI 
3 water HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   GLY n 
1 3   PHE n 
1 4   ARG n 
1 5   LYS n 
1 6   MET n 
1 7   ALA n 
1 8   PHE n 
1 9   PRO n 
1 10  SER n 
1 11  GLY n 
1 12  LYS n 
1 13  VAL n 
1 14  GLU n 
1 15  GLY n 
1 16  CYS n 
1 17  MET n 
1 18  VAL n 
1 19  GLN n 
1 20  VAL n 
1 21  THR n 
1 22  CYS n 
1 23  GLY n 
1 24  THR n 
1 25  THR n 
1 26  THR n 
1 27  LEU n 
1 28  ASN n 
1 29  GLY n 
1 30  LEU n 
1 31  TRP n 
1 32  LEU n 
1 33  ASP n 
1 34  ASP n 
1 35  VAL n 
1 36  VAL n 
1 37  TYR n 
1 38  CYS n 
1 39  PRO n 
1 40  ARG n 
1 41  HIS n 
1 42  VAL n 
1 43  ILE n 
1 44  CYS n 
1 45  THR n 
1 46  SER n 
1 47  GLU n 
1 48  ASP n 
1 49  MET n 
1 50  PHE n 
1 51  ASN n 
1 52  PRO n 
1 53  ASN n 
1 54  TYR n 
1 55  GLU n 
1 56  ASP n 
1 57  LEU n 
1 58  LEU n 
1 59  ILE n 
1 60  ARG n 
1 61  LYS n 
1 62  SER n 
1 63  ASN n 
1 64  HIS n 
1 65  ASN n 
1 66  PHE n 
1 67  LEU n 
1 68  VAL n 
1 69  GLN n 
1 70  ALA n 
1 71  GLY n 
1 72  ASN n 
1 73  VAL n 
1 74  GLN n 
1 75  LEU n 
1 76  ARG n 
1 77  VAL n 
1 78  ILE n 
1 79  GLY n 
1 80  HIS n 
1 81  SER n 
1 82  MET n 
1 83  GLN n 
1 84  ASN n 
1 85  CYS n 
1 86  VAL n 
1 87  LEU n 
1 88  LYS n 
1 89  LEU n 
1 90  LYS n 
1 91  VAL n 
1 92  ASP n 
1 93  THR n 
1 94  ALA n 
1 95  ASN n 
1 96  PRO n 
1 97  LYS n 
1 98  THR n 
1 99  PRO n 
1 100 LYS n 
1 101 TYR n 
1 102 LYS n 
1 103 PHE n 
1 104 VAL n 
1 105 ARG n 
1 106 ILE n 
1 107 GLN n 
1 108 PRO n 
1 109 GLY n 
1 110 GLN n 
1 111 THR n 
1 112 PHE n 
1 113 SER n 
1 114 VAL n 
1 115 LEU n 
1 116 ALA n 
1 117 CYS n 
1 118 TYR n 
1 119 ASN n 
1 120 GLY n 
1 121 SER n 
1 122 PRO n 
1 123 SER n 
1 124 GLY n 
1 125 VAL n 
1 126 TYR n 
1 127 GLN n 
1 128 CYS n 
1 129 ALA n 
1 130 MET n 
1 131 ARG n 
1 132 PRO n 
1 133 ASN n 
1 134 PHE n 
1 135 THR n 
1 136 ILE n 
1 137 LYS n 
1 138 GLY n 
1 139 SER n 
1 140 PHE n 
1 141 LEU n 
1 142 ASN n 
1 143 GLY n 
1 144 SER n 
1 145 CYS n 
1 146 GLY n 
1 147 SER n 
1 148 VAL n 
1 149 GLY n 
1 150 PHE n 
1 151 ASN n 
1 152 ILE n 
1 153 ASP n 
1 154 TYR n 
1 155 ASP n 
1 156 CYS n 
1 157 VAL n 
1 158 SER n 
1 159 PHE n 
1 160 CYS n 
1 161 TYR n 
1 162 MET n 
1 163 HIS n 
1 164 HIS n 
1 165 MET n 
1 166 GLU n 
1 167 LEU n 
1 168 PRO n 
1 169 THR n 
1 170 GLY n 
1 171 VAL n 
1 172 HIS n 
1 173 VAL n 
1 174 GLY n 
1 175 THR n 
1 176 ASP n 
1 177 LEU n 
1 178 GLU n 
1 179 GLY n 
1 180 ASN n 
1 181 PHE n 
1 182 TYR n 
1 183 GLY n 
1 184 PRO n 
1 185 PHE n 
1 186 VAL n 
1 187 ASP n 
1 188 ARG n 
1 189 GLN n 
1 190 THR n 
1 191 ALA n 
1 192 GLN n 
1 193 ALA n 
1 194 ALA n 
1 195 GLY n 
1 196 THR n 
1 197 ASP n 
1 198 THR n 
1 199 THR n 
1 200 ILE n 
1 201 THR n 
1 202 VAL n 
1 203 ASN n 
1 204 VAL n 
1 205 LEU n 
1 206 ALA n 
1 207 TRP n 
1 208 LEU n 
1 209 TYR n 
1 210 ALA n 
1 211 ALA n 
1 212 VAL n 
1 213 ILE n 
1 214 ASN n 
1 215 GLY n 
1 216 ASP n 
1 217 ARG n 
1 218 TRP n 
1 219 PHE n 
1 220 LEU n 
1 221 ASN n 
1 222 ARG n 
1 223 PHE n 
1 224 THR n 
1 225 THR n 
1 226 THR n 
1 227 LEU n 
1 228 ASN n 
1 229 ASP n 
1 230 PHE n 
1 231 ASN n 
1 232 LEU n 
1 233 VAL n 
1 234 ALA n 
1 235 MET n 
1 236 LYS n 
1 237 TYR n 
1 238 ASN n 
1 239 TYR n 
1 240 GLU n 
1 241 PRO n 
1 242 LEU n 
1 243 THR n 
1 244 GLN n 
1 245 ASP n 
1 246 HIS n 
1 247 VAL n 
1 248 ASP n 
1 249 ILE n 
1 250 LEU n 
1 251 GLY n 
1 252 PRO n 
1 253 LEU n 
1 254 SER n 
1 255 ALA n 
1 256 GLN n 
1 257 THR n 
1 258 GLY n 
1 259 ILE n 
1 260 ALA n 
1 261 VAL n 
1 262 LEU n 
1 263 ASP n 
1 264 MET n 
1 265 CYS n 
1 266 ALA n 
1 267 SER n 
1 268 LEU n 
1 269 LYS n 
1 270 GLU n 
1 271 LEU n 
1 272 LEU n 
1 273 GLN n 
1 274 ASN n 
1 275 GLY n 
1 276 MET n 
1 277 ASN n 
1 278 GLY n 
1 279 ARG n 
1 280 THR n 
1 281 ILE n 
1 282 LEU n 
1 283 GLY n 
1 284 SER n 
1 285 ALA n 
1 286 LEU n 
1 287 LEU n 
1 288 GLU n 
1 289 ASP n 
1 290 GLU n 
1 291 PHE n 
1 292 THR n 
1 293 PRO n 
1 294 PHE n 
1 295 ASP n 
1 296 VAL n 
1 297 VAL n 
1 298 ARG n 
1 299 GLN n 
1 300 CYS n 
1 301 SER n 
1 302 GLY n 
1 303 VAL n 
1 304 THR n 
1 305 PHE n 
1 306 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   306 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'rep, 1a-1b' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
4WI non-polymer         . 
;(1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide
;
'PF-07321332, bound form; nirmatrelvir, bound form; Paxlovid, bound form' 'C23 H34 F3 N5 O4' 501.542 
ALA 'L-peptide linking' y ALANINE ?                                                                         'C3 H7 N O2'       
89.093  
ARG 'L-peptide linking' y ARGININE ?                                                                         'C6 H15 N4 O2 1'   
175.209 
ASN 'L-peptide linking' y ASPARAGINE ?                                                                         'C4 H8 N2 O3'      
132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                                                                         'C4 H7 N O4' 
133.103 
CYS 'L-peptide linking' y CYSTEINE ?                                                                         'C3 H7 N O2 S'     
121.158 
GLN 'L-peptide linking' y GLUTAMINE ?                                                                         'C5 H10 N2 O3'     
146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                                                                         'C5 H9 N O4' 
147.129 
GLY 'peptide linking'   y GLYCINE ?                                                                         'C2 H5 N O2'       
75.067  
HIS 'L-peptide linking' y HISTIDINE ?                                                                         'C6 H10 N3 O2 1'   
156.162 
HOH non-polymer         . WATER ?                                                                         'H2 O'             
18.015  
ILE 'L-peptide linking' y ISOLEUCINE ?                                                                         'C6 H13 N O2'      
131.173 
LEU 'L-peptide linking' y LEUCINE ?                                                                         'C6 H13 N O2'      
131.173 
LYS 'L-peptide linking' y LYSINE ?                                                                         'C6 H15 N2 O2 1'   
147.195 
MET 'L-peptide linking' y METHIONINE ?                                                                         'C5 H11 N O2 S'    
149.211 
PHE 'L-peptide linking' y PHENYLALANINE ?                                                                         'C9 H11 N O2' 
165.189 
PRO 'L-peptide linking' y PROLINE ?                                                                         'C5 H9 N O2'       
115.130 
SER 'L-peptide linking' y SERINE ?                                                                         'C3 H7 N O3'       
105.093 
THR 'L-peptide linking' y THREONINE ?                                                                         'C4 H9 N O3'       
119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ?                                                                         'C11 H12 N2 O2'    
204.225 
TYR 'L-peptide linking' y TYROSINE ?                                                                         'C9 H11 N O3'      
181.189 
VAL 'L-peptide linking' y VALINE ?                                                                         'C5 H11 N O2'      
117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   1   1   SER SER A . n 
A 1 2   GLY 2   2   2   GLY GLY A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   ARG 4   4   4   ARG ARG A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   MET 6   6   6   MET MET A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   PRO 9   9   9   PRO PRO A . n 
A 1 10  SER 10  10  10  SER SER A . n 
A 1 11  GLY 11  11  11  GLY GLY A . n 
A 1 12  LYS 12  12  12  LYS LYS A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  GLY 15  15  15  GLY GLY A . n 
A 1 16  CYS 16  16  16  CYS CYS A . n 
A 1 17  MET 17  17  17  MET MET A . n 
A 1 18  VAL 18  18  18  VAL VAL A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  THR 21  21  21  THR THR A . n 
A 1 22  CYS 22  22  22  CYS CYS A . n 
A 1 23  GLY 23  23  23  GLY GLY A . n 
A 1 24  THR 24  24  24  THR THR A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  THR 26  26  26  THR THR A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  ASN 28  28  28  ASN ASN A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  TRP 31  31  31  TRP TRP A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  ASP 33  33  33  ASP ASP A . n 
A 1 34  ASP 34  34  34  ASP ASP A . n 
A 1 35  VAL 35  35  35  VAL VAL A . n 
A 1 36  VAL 36  36  36  VAL VAL A . n 
A 1 37  TYR 37  37  37  TYR TYR A . n 
A 1 38  CYS 38  38  38  CYS CYS A . n 
A 1 39  PRO 39  39  39  PRO PRO A . n 
A 1 40  ARG 40  40  40  ARG ARG A . n 
A 1 41  HIS 41  41  41  HIS HIS A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  ILE 43  43  43  ILE ILE A . n 
A 1 44  CYS 44  44  44  CYS CYS A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  SER 46  46  46  SER SER A . n 
A 1 47  GLU 47  47  47  GLU GLU A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  MET 49  49  49  MET MET A . n 
A 1 50  PHE 50  50  50  PHE PHE A . n 
A 1 51  ASN 51  51  51  ASN ASN A . n 
A 1 52  PRO 52  52  52  PRO PRO A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  TYR 54  54  54  TYR TYR A . n 
A 1 55  GLU 55  55  55  GLU GLU A . n 
A 1 56  ASP 56  56  56  ASP ASP A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  ILE 59  59  59  ILE ILE A . n 
A 1 60  ARG 60  60  60  ARG ARG A . n 
A 1 61  LYS 61  61  61  LYS LYS A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  ASN 63  63  63  ASN ASN A . n 
A 1 64  HIS 64  64  64  HIS HIS A . n 
A 1 65  ASN 65  65  65  ASN ASN A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  GLN 69  69  69  GLN GLN A . n 
A 1 70  ALA 70  70  70  ALA ALA A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  ASN 72  72  72  ASN ASN A . n 
A 1 73  VAL 73  73  73  VAL VAL A . n 
A 1 74  GLN 74  74  74  GLN GLN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  ARG 76  76  76  ARG ARG A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  GLY 79  79  79  GLY GLY A . n 
A 1 80  HIS 80  80  80  HIS HIS A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  MET 82  82  82  MET MET A . n 
A 1 83  GLN 83  83  83  GLN GLN A . n 
A 1 84  ASN 84  84  84  ASN ASN A . n 
A 1 85  CYS 85  85  85  CYS CYS A . n 
A 1 86  VAL 86  86  86  VAL VAL A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  LYS 88  88  88  LYS LYS A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  LYS 90  90  90  LYS LYS A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  ASP 92  92  92  ASP ASP A . n 
A 1 93  THR 93  93  93  THR THR A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  PRO 96  96  96  PRO PRO A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  PRO 99  99  99  PRO PRO A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 TYR 101 101 101 TYR TYR A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 PHE 103 103 103 PHE PHE A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 ARG 105 105 105 ARG ARG A . n 
A 1 106 ILE 106 106 106 ILE ILE A . n 
A 1 107 GLN 107 107 107 GLN GLN A . n 
A 1 108 PRO 108 108 108 PRO PRO A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 GLN 110 110 110 GLN GLN A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 PHE 112 112 112 PHE PHE A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 CYS 117 117 117 CYS CYS A . n 
A 1 118 TYR 118 118 118 TYR TYR A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 SER 123 123 123 SER SER A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 MET 130 130 130 MET MET A . n 
A 1 131 ARG 131 131 131 ARG ARG A . n 
A 1 132 PRO 132 132 132 PRO PRO A . n 
A 1 133 ASN 133 133 133 ASN ASN A . n 
A 1 134 PHE 134 134 134 PHE PHE A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 LYS 137 137 137 LYS LYS A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 PHE 140 140 140 PHE PHE A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 ASN 142 142 142 ASN ASN A . n 
A 1 143 GLY 143 143 143 GLY GLY A . n 
A 1 144 SER 144 144 144 SER SER A . n 
A 1 145 CYS 145 145 145 CYS CYS A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 GLY 149 149 149 GLY GLY A . n 
A 1 150 PHE 150 150 150 PHE PHE A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 ILE 152 152 152 ILE ILE A . n 
A 1 153 ASP 153 153 153 ASP ASP A . n 
A 1 154 TYR 154 154 154 TYR TYR A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 CYS 156 156 156 CYS CYS A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 SER 158 158 158 SER SER A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 CYS 160 160 160 CYS CYS A . n 
A 1 161 TYR 161 161 161 TYR TYR A . n 
A 1 162 MET 162 162 162 MET MET A . n 
A 1 163 HIS 163 163 163 HIS HIS A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 MET 165 165 165 MET MET A . n 
A 1 166 GLU 166 166 166 GLU GLU A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 PRO 168 168 168 PRO PRO A . n 
A 1 169 THR 169 169 169 THR THR A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 VAL 171 171 171 VAL VAL A . n 
A 1 172 HIS 172 172 172 HIS HIS A . n 
A 1 173 VAL 173 173 173 VAL VAL A . n 
A 1 174 GLY 174 174 174 GLY GLY A . n 
A 1 175 THR 175 175 175 THR THR A . n 
A 1 176 ASP 176 176 176 ASP ASP A . n 
A 1 177 LEU 177 177 177 LEU LEU A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 TYR 182 182 182 TYR TYR A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 VAL 186 186 186 VAL VAL A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 GLN 189 189 189 GLN GLN A . n 
A 1 190 THR 190 190 190 THR THR A . n 
A 1 191 ALA 191 191 191 ALA ALA A . n 
A 1 192 GLN 192 192 192 GLN GLN A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 THR 196 196 196 THR THR A . n 
A 1 197 ASP 197 197 197 ASP ASP A . n 
A 1 198 THR 198 198 198 THR THR A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 ILE 200 200 200 ILE ILE A . n 
A 1 201 THR 201 201 201 THR THR A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 ALA 206 206 206 ALA ALA A . n 
A 1 207 TRP 207 207 207 TRP TRP A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ALA 210 210 210 ALA ALA A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ASN 214 214 214 ASN ASN A . n 
A 1 215 GLY 215 215 215 GLY GLY A . n 
A 1 216 ASP 216 216 216 ASP ASP A . n 
A 1 217 ARG 217 217 217 ARG ARG A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 ASN 221 221 221 ASN ASN A . n 
A 1 222 ARG 222 222 222 ARG ARG A . n 
A 1 223 PHE 223 223 223 PHE PHE A . n 
A 1 224 THR 224 224 224 THR THR A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 THR 226 226 226 THR THR A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 ASN 228 228 228 ASN ASN A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 PHE 230 230 230 PHE PHE A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 VAL 233 233 233 VAL VAL A . n 
A 1 234 ALA 234 234 234 ALA ALA A . n 
A 1 235 MET 235 235 235 MET MET A . n 
A 1 236 LYS 236 236 236 LYS LYS A . n 
A 1 237 TYR 237 237 237 TYR TYR A . n 
A 1 238 ASN 238 238 238 ASN ASN A . n 
A 1 239 TYR 239 239 239 TYR TYR A . n 
A 1 240 GLU 240 240 240 GLU GLU A . n 
A 1 241 PRO 241 241 241 PRO PRO A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 THR 243 243 243 THR THR A . n 
A 1 244 GLN 244 244 244 GLN GLN A . n 
A 1 245 ASP 245 245 245 ASP ASP A . n 
A 1 246 HIS 246 246 246 HIS HIS A . n 
A 1 247 VAL 247 247 247 VAL VAL A . n 
A 1 248 ASP 248 248 248 ASP ASP A . n 
A 1 249 ILE 249 249 249 ILE ILE A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 PRO 252 252 252 PRO PRO A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 SER 254 254 254 SER SER A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 THR 257 257 257 THR THR A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 ILE 259 259 259 ILE ILE A . n 
A 1 260 ALA 260 260 260 ALA ALA A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 LEU 262 262 262 LEU LEU A . n 
A 1 263 ASP 263 263 263 ASP ASP A . n 
A 1 264 MET 264 264 264 MET MET A . n 
A 1 265 CYS 265 265 265 CYS CYS A . n 
A 1 266 ALA 266 266 266 ALA ALA A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 LYS 269 269 269 LYS LYS A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 LEU 271 271 271 LEU LEU A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 ASN 274 274 274 ASN ASN A . n 
A 1 275 GLY 275 275 275 GLY GLY A . n 
A 1 276 MET 276 276 276 MET MET A . n 
A 1 277 ASN 277 277 277 ASN ASN A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 ARG 279 279 279 ARG ARG A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 ILE 281 281 281 ILE ILE A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 GLY 283 283 283 GLY GLY A . n 
A 1 284 SER 284 284 284 SER SER A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 LEU 286 286 286 LEU LEU A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 ASP 289 289 289 ASP ASP A . n 
A 1 290 GLU 290 290 290 GLU GLU A . n 
A 1 291 PHE 291 291 291 PHE PHE A . n 
A 1 292 THR 292 292 292 THR THR A . n 
A 1 293 PRO 293 293 293 PRO PRO A . n 
A 1 294 PHE 294 294 294 PHE PHE A . n 
A 1 295 ASP 295 295 295 ASP ASP A . n 
A 1 296 VAL 296 296 296 VAL VAL A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 GLN 299 299 299 GLN GLN A . n 
A 1 300 CYS 300 300 300 CYS CYS A . n 
A 1 301 SER 301 301 301 SER SER A . n 
A 1 302 GLY 302 302 302 GLY GLY A . n 
A 1 303 VAL 303 303 303 VAL VAL A . n 
A 1 304 THR 304 304 304 THR THR A . n 
A 1 305 PHE 305 307 307 PHE PHE A . n 
A 1 306 GLN 306 308 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        4WI 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   4WI 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 4WI 1   401 999 4WI NMA A . 
C 3 HOH 1   501 20  HOH HOH A . 
C 3 HOH 2   502 166 HOH HOH A . 
C 3 HOH 3   503 122 HOH HOH A . 
C 3 HOH 4   504 80  HOH HOH A . 
C 3 HOH 5   505 199 HOH HOH A . 
C 3 HOH 6   506 95  HOH HOH A . 
C 3 HOH 7   507 65  HOH HOH A . 
C 3 HOH 8   508 24  HOH HOH A . 
C 3 HOH 9   509 186 HOH HOH A . 
C 3 HOH 10  510 52  HOH HOH A . 
C 3 HOH 11  511 8   HOH HOH A . 
C 3 HOH 12  512 72  HOH HOH A . 
C 3 HOH 13  513 127 HOH HOH A . 
C 3 HOH 14  514 61  HOH HOH A . 
C 3 HOH 15  515 35  HOH HOH A . 
C 3 HOH 16  516 189 HOH HOH A . 
C 3 HOH 17  517 218 HOH HOH A . 
C 3 HOH 18  518 45  HOH HOH A . 
C 3 HOH 19  519 108 HOH HOH A . 
C 3 HOH 20  520 158 HOH HOH A . 
C 3 HOH 21  521 191 HOH HOH A . 
C 3 HOH 22  522 98  HOH HOH A . 
C 3 HOH 23  523 53  HOH HOH A . 
C 3 HOH 24  524 68  HOH HOH A . 
C 3 HOH 25  525 159 HOH HOH A . 
C 3 HOH 26  526 156 HOH HOH A . 
C 3 HOH 27  527 85  HOH HOH A . 
C 3 HOH 28  528 18  HOH HOH A . 
C 3 HOH 29  529 87  HOH HOH A . 
C 3 HOH 30  530 93  HOH HOH A . 
C 3 HOH 31  531 23  HOH HOH A . 
C 3 HOH 32  532 192 HOH HOH A . 
C 3 HOH 33  533 99  HOH HOH A . 
C 3 HOH 34  534 143 HOH HOH A . 
C 3 HOH 35  535 90  HOH HOH A . 
C 3 HOH 36  536 130 HOH HOH A . 
C 3 HOH 37  537 57  HOH HOH A . 
C 3 HOH 38  538 6   HOH HOH A . 
C 3 HOH 39  539 112 HOH HOH A . 
C 3 HOH 40  540 7   HOH HOH A . 
C 3 HOH 41  541 145 HOH HOH A . 
C 3 HOH 42  542 147 HOH HOH A . 
C 3 HOH 43  543 33  HOH HOH A . 
C 3 HOH 44  544 37  HOH HOH A . 
C 3 HOH 45  545 48  HOH HOH A . 
C 3 HOH 46  546 141 HOH HOH A . 
C 3 HOH 47  547 27  HOH HOH A . 
C 3 HOH 48  548 26  HOH HOH A . 
C 3 HOH 49  549 36  HOH HOH A . 
C 3 HOH 50  550 188 HOH HOH A . 
C 3 HOH 51  551 47  HOH HOH A . 
C 3 HOH 52  552 63  HOH HOH A . 
C 3 HOH 53  553 3   HOH HOH A . 
C 3 HOH 54  554 42  HOH HOH A . 
C 3 HOH 55  555 204 HOH HOH A . 
C 3 HOH 56  556 212 HOH HOH A . 
C 3 HOH 57  557 17  HOH HOH A . 
C 3 HOH 58  558 34  HOH HOH A . 
C 3 HOH 59  559 116 HOH HOH A . 
C 3 HOH 60  560 152 HOH HOH A . 
C 3 HOH 61  561 5   HOH HOH A . 
C 3 HOH 62  562 59  HOH HOH A . 
C 3 HOH 63  563 73  HOH HOH A . 
C 3 HOH 64  564 154 HOH HOH A . 
C 3 HOH 65  565 38  HOH HOH A . 
C 3 HOH 66  566 56  HOH HOH A . 
C 3 HOH 67  567 100 HOH HOH A . 
C 3 HOH 68  568 78  HOH HOH A . 
C 3 HOH 69  569 22  HOH HOH A . 
C 3 HOH 70  570 187 HOH HOH A . 
C 3 HOH 71  571 139 HOH HOH A . 
C 3 HOH 72  572 1   HOH HOH A . 
C 3 HOH 73  573 46  HOH HOH A . 
C 3 HOH 74  574 79  HOH HOH A . 
C 3 HOH 75  575 84  HOH HOH A . 
C 3 HOH 76  576 4   HOH HOH A . 
C 3 HOH 77  577 11  HOH HOH A . 
C 3 HOH 78  578 106 HOH HOH A . 
C 3 HOH 79  579 94  HOH HOH A . 
C 3 HOH 80  580 207 HOH HOH A . 
C 3 HOH 81  581 161 HOH HOH A . 
C 3 HOH 82  582 77  HOH HOH A . 
C 3 HOH 83  583 44  HOH HOH A . 
C 3 HOH 84  584 88  HOH HOH A . 
C 3 HOH 85  585 118 HOH HOH A . 
C 3 HOH 86  586 120 HOH HOH A . 
C 3 HOH 87  587 126 HOH HOH A . 
C 3 HOH 88  588 113 HOH HOH A . 
C 3 HOH 89  589 102 HOH HOH A . 
C 3 HOH 90  590 196 HOH HOH A . 
C 3 HOH 91  591 217 HOH HOH A . 
C 3 HOH 92  592 67  HOH HOH A . 
C 3 HOH 93  593 21  HOH HOH A . 
C 3 HOH 94  594 40  HOH HOH A . 
C 3 HOH 95  595 224 HOH HOH A . 
C 3 HOH 96  596 175 HOH HOH A . 
C 3 HOH 97  597 128 HOH HOH A . 
C 3 HOH 98  598 13  HOH HOH A . 
C 3 HOH 99  599 30  HOH HOH A . 
C 3 HOH 100 600 12  HOH HOH A . 
C 3 HOH 101 601 117 HOH HOH A . 
C 3 HOH 102 602 54  HOH HOH A . 
C 3 HOH 103 603 142 HOH HOH A . 
C 3 HOH 104 604 50  HOH HOH A . 
C 3 HOH 105 605 55  HOH HOH A . 
C 3 HOH 106 606 146 HOH HOH A . 
C 3 HOH 107 607 71  HOH HOH A . 
C 3 HOH 108 608 82  HOH HOH A . 
C 3 HOH 109 609 70  HOH HOH A . 
C 3 HOH 110 610 25  HOH HOH A . 
C 3 HOH 111 611 105 HOH HOH A . 
C 3 HOH 112 612 9   HOH HOH A . 
C 3 HOH 113 613 49  HOH HOH A . 
C 3 HOH 114 614 32  HOH HOH A . 
C 3 HOH 115 615 210 HOH HOH A . 
C 3 HOH 116 616 51  HOH HOH A . 
C 3 HOH 117 617 16  HOH HOH A . 
C 3 HOH 118 618 75  HOH HOH A . 
C 3 HOH 119 619 15  HOH HOH A . 
C 3 HOH 120 620 96  HOH HOH A . 
C 3 HOH 121 621 28  HOH HOH A . 
C 3 HOH 122 622 19  HOH HOH A . 
C 3 HOH 123 623 216 HOH HOH A . 
C 3 HOH 124 624 214 HOH HOH A . 
C 3 HOH 125 625 183 HOH HOH A . 
C 3 HOH 126 626 29  HOH HOH A . 
C 3 HOH 127 627 135 HOH HOH A . 
C 3 HOH 128 628 89  HOH HOH A . 
C 3 HOH 129 629 185 HOH HOH A . 
C 3 HOH 130 630 97  HOH HOH A . 
C 3 HOH 131 631 225 HOH HOH A . 
C 3 HOH 132 632 76  HOH HOH A . 
C 3 HOH 133 633 69  HOH HOH A . 
C 3 HOH 134 634 181 HOH HOH A . 
C 3 HOH 135 635 107 HOH HOH A . 
C 3 HOH 136 636 148 HOH HOH A . 
C 3 HOH 137 637 144 HOH HOH A . 
C 3 HOH 138 638 41  HOH HOH A . 
C 3 HOH 139 639 101 HOH HOH A . 
C 3 HOH 140 640 160 HOH HOH A . 
C 3 HOH 141 641 170 HOH HOH A . 
C 3 HOH 142 642 60  HOH HOH A . 
C 3 HOH 143 643 197 HOH HOH A . 
C 3 HOH 144 644 92  HOH HOH A . 
C 3 HOH 145 645 206 HOH HOH A . 
C 3 HOH 146 646 81  HOH HOH A . 
C 3 HOH 147 647 14  HOH HOH A . 
C 3 HOH 148 648 133 HOH HOH A . 
C 3 HOH 149 649 31  HOH HOH A . 
C 3 HOH 150 650 64  HOH HOH A . 
C 3 HOH 151 651 43  HOH HOH A . 
C 3 HOH 152 652 140 HOH HOH A . 
C 3 HOH 153 653 83  HOH HOH A . 
C 3 HOH 154 654 153 HOH HOH A . 
C 3 HOH 155 655 109 HOH HOH A . 
C 3 HOH 156 656 10  HOH HOH A . 
C 3 HOH 157 657 221 HOH HOH A . 
C 3 HOH 158 658 163 HOH HOH A . 
C 3 HOH 159 659 58  HOH HOH A . 
C 3 HOH 160 660 179 HOH HOH A . 
C 3 HOH 161 661 174 HOH HOH A . 
C 3 HOH 162 662 172 HOH HOH A . 
C 3 HOH 163 663 2   HOH HOH A . 
C 3 HOH 164 664 205 HOH HOH A . 
C 3 HOH 165 665 200 HOH HOH A . 
C 3 HOH 166 666 178 HOH HOH A . 
C 3 HOH 167 667 168 HOH HOH A . 
C 3 HOH 168 668 182 HOH HOH A . 
C 3 HOH 169 669 169 HOH HOH A . 
C 3 HOH 170 670 165 HOH HOH A . 
C 3 HOH 171 671 164 HOH HOH A . 
C 3 HOH 172 672 138 HOH HOH A . 
C 3 HOH 173 673 150 HOH HOH A . 
C 3 HOH 174 674 74  HOH HOH A . 
C 3 HOH 175 675 104 HOH HOH A . 
C 3 HOH 176 676 209 HOH HOH A . 
C 3 HOH 177 677 136 HOH HOH A . 
C 3 HOH 178 678 213 HOH HOH A . 
C 3 HOH 179 679 223 HOH HOH A . 
C 3 HOH 180 680 184 HOH HOH A . 
C 3 HOH 181 681 66  HOH HOH A . 
C 3 HOH 182 682 167 HOH HOH A . 
C 3 HOH 183 683 226 HOH HOH A . 
C 3 HOH 184 684 151 HOH HOH A . 
C 3 HOH 185 685 123 HOH HOH A . 
C 3 HOH 186 686 171 HOH HOH A . 
C 3 HOH 187 687 155 HOH HOH A . 
C 3 HOH 188 688 121 HOH HOH A . 
C 3 HOH 189 689 202 HOH HOH A . 
C 3 HOH 190 690 91  HOH HOH A . 
C 3 HOH 191 691 86  HOH HOH A . 
C 3 HOH 192 692 215 HOH HOH A . 
C 3 HOH 193 693 129 HOH HOH A . 
C 3 HOH 194 694 195 HOH HOH A . 
C 3 HOH 195 695 62  HOH HOH A . 
C 3 HOH 196 696 125 HOH HOH A . 
C 3 HOH 197 697 111 HOH HOH A . 
C 3 HOH 198 698 201 HOH HOH A . 
C 3 HOH 199 699 131 HOH HOH A . 
C 3 HOH 200 700 194 HOH HOH A . 
C 3 HOH 201 701 173 HOH HOH A . 
C 3 HOH 202 702 124 HOH HOH A . 
C 3 HOH 203 703 114 HOH HOH A . 
C 3 HOH 204 704 149 HOH HOH A . 
C 3 HOH 205 705 219 HOH HOH A . 
C 3 HOH 206 706 211 HOH HOH A . 
C 3 HOH 207 707 177 HOH HOH A . 
C 3 HOH 208 708 190 HOH HOH A . 
C 3 HOH 209 709 198 HOH HOH A . 
C 3 HOH 210 710 132 HOH HOH A . 
C 3 HOH 211 711 220 HOH HOH A . 
C 3 HOH 212 712 103 HOH HOH A . 
C 3 HOH 213 713 134 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A GLU 47  ? CG  ? A GLU 47  CG  
2  1 Y 1 A GLU 47  ? CD  ? A GLU 47  CD  
3  1 Y 1 A GLU 47  ? OE1 ? A GLU 47  OE1 
4  1 Y 1 A GLU 47  ? OE2 ? A GLU 47  OE2 
5  1 Y 1 A ASN 51  ? CG  ? A ASN 51  CG  
6  1 Y 1 A ASN 51  ? OD1 ? A ASN 51  OD1 
7  1 Y 1 A ASN 51  ? ND2 ? A ASN 51  ND2 
8  1 Y 1 A ARG 60  ? CG  ? A ARG 60  CG  
9  1 Y 1 A ARG 60  ? CD  ? A ARG 60  CD  
10 1 Y 1 A ARG 60  ? NE  ? A ARG 60  NE  
11 1 Y 1 A ARG 60  ? CZ  ? A ARG 60  CZ  
12 1 Y 1 A ARG 60  ? NH1 ? A ARG 60  NH1 
13 1 Y 1 A ARG 60  ? NH2 ? A ARG 60  NH2 
14 1 Y 1 A ASN 72  ? CG  ? A ASN 72  CG  
15 1 Y 1 A ASN 72  ? OD1 ? A ASN 72  OD1 
16 1 Y 1 A ASN 72  ? ND2 ? A ASN 72  ND2 
17 1 Y 1 A MET 235 ? CG  ? A MET 235 CG  
18 1 Y 1 A MET 235 ? SD  ? A MET 235 SD  
19 1 Y 1 A MET 235 ? CE  ? A MET 235 CE  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BO6 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     45.372 
_cell.length_a_esd                 ? 
_cell.length_b                     63.359 
_cell.length_b_esd                 ? 
_cell.length_c                     105.736 
_cell.length_c_esd                 ? 
_cell.volume                       303961.875 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BO6 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                18 
_symmetry.space_group_name_Hall            'P 2 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BO6 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.24 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          45.15 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              4.0 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M Sodium acetate trihydrate pH 4.0, 10% v/v Jeffamine M-600 pH 7.0' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            294 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-11-30 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.920085 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSLS-II BEAMLINE 17-ID-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.920085 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   17-ID-1 
_diffrn_source.pdbx_synchrotron_site       NSLS-II 
# 
_reflns.B_iso_Wilson_estimate                          23.36 
_reflns.entry_id                                       9BO6 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.61 
_reflns.d_resolution_low                               34.43 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     40030 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.91 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                11.6 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          9.20 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.997 
_reflns.pdbx_CC_star                                   0.999 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.1609 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.61 
_reflns_shell.d_res_low                                     1.671 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           0.55 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3908 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               8.9 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.391 
_reflns_shell.pdbx_CC_star                                  0.75 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.44 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               27.84 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9BO6 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.61 
_refine.ls_d_res_low                             34.43 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     40007 
_refine.ls_number_reflns_R_free                  1985 
_refine.ls_number_reflns_R_work                  38022 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.93 
_refine.ls_percent_reflns_R_free                 4.96 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1927 
_refine.ls_R_factor_R_free                       0.2226 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1910 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 25.1556 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2174 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.61 
_refine_hist.d_res_low                        34.43 
_refine_hist.number_atoms_solvent             213 
_refine_hist.number_atoms_total               2592 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2344 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         35 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0104  ? 2459 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.1904  ? 3360 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0688  ? 379  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0103  ? 432  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 11.7683 ? 872  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.61 1.65  . . 112 2659 99.32  . . . . 0.3452 . . . . . . . . . . . 0.3156 
'X-RAY DIFFRACTION' 1.65 1.70  . . 155 2667 99.86  . . . . 0.3015 . . . . . . . . . . . 0.3970 
'X-RAY DIFFRACTION' 1.70 1.75  . . 139 2684 99.96  . . . . 0.2661 . . . . . . . . . . . 0.3269 
'X-RAY DIFFRACTION' 1.75 1.81  . . 128 2671 99.96  . . . . 0.2434 . . . . . . . . . . . 0.2985 
'X-RAY DIFFRACTION' 1.81 1.87  . . 131 2702 100.00 . . . . 0.2335 . . . . . . . . . . . 0.2573 
'X-RAY DIFFRACTION' 1.87 1.94  . . 134 2693 100.00 . . . . 0.2200 . . . . . . . . . . . 0.2952 
'X-RAY DIFFRACTION' 1.94 2.03  . . 139 2681 99.96  . . . . 0.1872 . . . . . . . . . . . 0.2425 
'X-RAY DIFFRACTION' 2.03 2.14  . . 147 2703 100.00 . . . . 0.1878 . . . . . . . . . . . 0.2379 
'X-RAY DIFFRACTION' 2.14 2.27  . . 154 2703 100.00 . . . . 0.1812 . . . . . . . . . . . 0.2320 
'X-RAY DIFFRACTION' 2.27 2.45  . . 125 2731 100.00 . . . . 0.1929 . . . . . . . . . . . 0.2330 
'X-RAY DIFFRACTION' 2.45 2.70  . . 142 2728 100.00 . . . . 0.1918 . . . . . . . . . . . 0.2462 
'X-RAY DIFFRACTION' 2.70 3.09  . . 162 2710 99.97  . . . . 0.1923 . . . . . . . . . . . 0.2166 
'X-RAY DIFFRACTION' 3.09 3.89  . . 146 2786 100.00 . . . . 0.1671 . . . . . . . . . . . 0.2004 
'X-RAY DIFFRACTION' 3.89 34.43 . . 171 2904 99.94  . . . . 0.1713 . . . . . . . . . . . 0.1803 
# 
_struct.entry_id                     9BO6 
_struct.title                        'Crystal Structure of A173V/L50F SARS-CoV-2 Main Protease in Complex with Nirmatrelvir' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BO6 
_struct_keywords.text            'Hydrolase, VIRAL PROTEIN' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1AB_SARS2 
_struct_ref.pdbx_db_accession          P0DTD1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_struct_ref.pdbx_align_begin           3264 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9BO6 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 306 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P0DTD1 
_struct_ref_seq.db_align_beg                  3264 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3569 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       308 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9BO6 PHE A 50  ? UNP P0DTD1 LEU 3313 'engineered mutation' 50  1 
1 9BO6 VAL A 173 ? UNP P0DTD1 ALA 3436 'engineered mutation' 173 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 3050  ? 
1 MORE         -15   ? 
1 'SSA (A^2)'  24580 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z     1.0000000000  0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  
0.0000000000 0.0000000000  0.0000000000 0.0000000000 1.0000000000 0.0000000000 
2 'crystal symmetry operation' 2_565 -x,-y+1,z -1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 
0.0000000000 63.3590000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 10  ? GLY A 15  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 41  ? CYS A 44  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 THR A 45  ? ASN A 51  ? THR A 45  ASN A 51  5 ? 7  
HELX_P HELX_P4  AA4 ASN A 53  ? ARG A 60  ? ASN A 53  ARG A 60  1 ? 8  
HELX_P HELX_P5  AA5 SER A 62  ? HIS A 64  ? SER A 62  HIS A 64  5 ? 3  
HELX_P HELX_P6  AA6 ILE A 200 ? ASN A 214 ? ILE A 200 ASN A 214 1 ? 15 
HELX_P HELX_P7  AA7 THR A 226 ? TYR A 237 ? THR A 226 TYR A 237 1 ? 12 
HELX_P HELX_P8  AA8 THR A 243 ? LEU A 250 ? THR A 243 LEU A 250 1 ? 8  
HELX_P HELX_P9  AA9 LEU A 250 ? GLY A 258 ? LEU A 250 GLY A 258 1 ? 9  
HELX_P HELX_P10 AB1 ALA A 260 ? GLY A 275 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P11 AB2 THR A 292 ? GLY A 302 ? THR A 292 GLY A 302 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            covale1 
_struct_conn.conn_type_id                  covale 
_struct_conn.pdbx_leaving_atom_flag        none 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            145 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           B 
_struct_conn.ptnr2_label_comp_id           4WI 
_struct_conn.ptnr2_label_seq_id            . 
_struct_conn.ptnr2_label_atom_id           C3 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             145 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            4WI 
_struct_conn.ptnr2_auth_seq_id             401 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               1.777 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      4WI 
_pdbx_modification_feature.label_asym_id                      B 
_pdbx_modification_feature.label_seq_id                       . 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      145 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       4WI 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        401 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       145 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               C3 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                CYS 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        4WI 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Covalent chemical modification' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 73  ? LEU A 75  ? VAL A 73  LEU A 75  
AA1 2 PHE A 66  ? ALA A 70  ? PHE A 66  ALA A 70  
AA1 3 MET A 17  ? CYS A 22  ? MET A 17  CYS A 22  
AA1 4 THR A 25  ? LEU A 32  ? THR A 25  LEU A 32  
AA1 5 VAL A 35  ? PRO A 39  ? VAL A 35  PRO A 39  
AA1 6 VAL A 86  ? VAL A 91  ? VAL A 86  VAL A 91  
AA1 7 VAL A 77  ? GLN A 83  ? VAL A 77  GLN A 83  
AA2 1 LYS A 100 ? PHE A 103 ? LYS A 100 PHE A 103 
AA2 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA2 3 VAL A 148 ? ASP A 153 ? VAL A 148 ASP A 153 
AA2 4 THR A 111 ? TYR A 118 ? THR A 111 TYR A 118 
AA2 5 SER A 121 ? ALA A 129 ? SER A 121 ALA A 129 
AA3 1 LYS A 100 ? PHE A 103 ? LYS A 100 PHE A 103 
AA3 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA3 3 HIS A 172 ? THR A 175 ? HIS A 172 THR A 175 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL A 73  ? O VAL A 73  N ALA A 70  ? N ALA A 70  
AA1 2 3 O LEU A 67  ? O LEU A 67  N THR A 21  ? N THR A 21  
AA1 3 4 N VAL A 18  ? N VAL A 18  O GLY A 29  ? O GLY A 29  
AA1 4 5 N LEU A 30  ? N LEU A 30  O TYR A 37  ? O TYR A 37  
AA1 5 6 N CYS A 38  ? N CYS A 38  O LEU A 87  ? O LEU A 87  
AA1 6 7 O LYS A 88  ? O LYS A 88  N SER A 81  ? N SER A 81  
AA2 1 2 N LYS A 100 ? N LYS A 100 O VAL A 157 ? O VAL A 157 
AA2 2 3 O CYS A 156 ? O CYS A 156 N ASP A 153 ? N ASP A 153 
AA2 3 4 O PHE A 150 ? O PHE A 150 N SER A 113 ? N SER A 113 
AA2 4 5 N ALA A 116 ? N ALA A 116 O SER A 123 ? O SER A 123 
AA3 1 2 N LYS A 100 ? N LYS A 100 O VAL A 157 ? O VAL A 157 
AA3 2 3 N MET A 165 ? N MET A 165 O VAL A 173 ? O VAL A 173 
# 
_pdbx_entry_details.entry_id                   9BO6 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 33  ? ? 49.22   -125.91 
2 1 ASN A 51  ? ? -151.02 65.43   
3 1 ASN A 84  ? ? 51.26   -123.58 
4 1 TYR A 154 ? ? 57.40   -99.60  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x+1/2,y+1/2,-z 
4 -x,-y,z         
# 
_pdbx_unobs_or_zero_occ_residues.id               1 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num    1 
_pdbx_unobs_or_zero_occ_residues.polymer_flag     Y 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag   1 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id     A 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id     GLN 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id      308 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code     ? 
_pdbx_unobs_or_zero_occ_residues.label_asym_id    A 
_pdbx_unobs_or_zero_occ_residues.label_comp_id    GLN 
_pdbx_unobs_or_zero_occ_residues.label_seq_id     306 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
4WI C8   C N N 1   
4WI C3   C N N 2   
4WI C1   C N N 3   
4WI C13  C N N 4   
4WI C21  C N N 5   
4WI C6   C N N 6   
4WI C7   C N N 7   
4WI C10  C N N 8   
4WI C5   C N S 9   
4WI C9   C N S 10  
4WI C11  C N S 11  
4WI C12  C N R 12  
4WI C18  C N N 13  
4WI C19  C N N 14  
4WI C20  C N N 15  
4WI C16  C N N 16  
4WI C17  C N N 17  
4WI C23  C N N 18  
4WI C4   C N N 19  
4WI C2   C N S 20  
4WI C14  C N S 21  
4WI C22  C N N 22  
4WI C15  C N N 23  
4WI N5   N N N 24  
4WI N2   N N N 25  
4WI N3   N N N 26  
4WI N1   N N N 27  
4WI N4   N N N 28  
4WI O1   O N N 29  
4WI O2   O N N 30  
4WI O3   O N N 31  
4WI O4   O N N 32  
4WI F1   F N N 33  
4WI F2   F N N 34  
4WI F3   F N N 35  
4WI H33  H N N 36  
4WI H5   H N N 37  
4WI H6   H N N 38  
4WI H7   H N N 39  
4WI H8   H N N 40  
4WI H11  H N N 41  
4WI H12  H N N 42  
4WI H4   H N N 43  
4WI H10  H N N 44  
4WI H13  H N N 45  
4WI H14  H N N 46  
4WI H23  H N N 47  
4WI H24  H N N 48  
4WI H25  H N N 49  
4WI H26  H N N 50  
4WI H27  H N N 51  
4WI H28  H N N 52  
4WI H17  H N N 53  
4WI H19  H N N 54  
4WI H18  H N N 55  
4WI H20  H N N 56  
4WI H21  H N N 57  
4WI H22  H N N 58  
4WI H29  H N N 59  
4WI H30  H N N 60  
4WI H31  H N N 61  
4WI H2   H N N 62  
4WI H3   H N N 63  
4WI H32  H N N 64  
4WI H15  H N N 65  
4WI H36  H N N 66  
4WI H9   H N N 67  
4WI H1   H N N 68  
4WI H16  H N N 69  
ALA N    N N N 70  
ALA CA   C N S 71  
ALA C    C N N 72  
ALA O    O N N 73  
ALA CB   C N N 74  
ALA OXT  O N N 75  
ALA H    H N N 76  
ALA H2   H N N 77  
ALA HA   H N N 78  
ALA HB1  H N N 79  
ALA HB2  H N N 80  
ALA HB3  H N N 81  
ALA HXT  H N N 82  
ARG N    N N N 83  
ARG CA   C N S 84  
ARG C    C N N 85  
ARG O    O N N 86  
ARG CB   C N N 87  
ARG CG   C N N 88  
ARG CD   C N N 89  
ARG NE   N N N 90  
ARG CZ   C N N 91  
ARG NH1  N N N 92  
ARG NH2  N N N 93  
ARG OXT  O N N 94  
ARG H    H N N 95  
ARG H2   H N N 96  
ARG HA   H N N 97  
ARG HB2  H N N 98  
ARG HB3  H N N 99  
ARG HG2  H N N 100 
ARG HG3  H N N 101 
ARG HD2  H N N 102 
ARG HD3  H N N 103 
ARG HE   H N N 104 
ARG HH11 H N N 105 
ARG HH12 H N N 106 
ARG HH21 H N N 107 
ARG HH22 H N N 108 
ARG HXT  H N N 109 
ASN N    N N N 110 
ASN CA   C N S 111 
ASN C    C N N 112 
ASN O    O N N 113 
ASN CB   C N N 114 
ASN CG   C N N 115 
ASN OD1  O N N 116 
ASN ND2  N N N 117 
ASN OXT  O N N 118 
ASN H    H N N 119 
ASN H2   H N N 120 
ASN HA   H N N 121 
ASN HB2  H N N 122 
ASN HB3  H N N 123 
ASN HD21 H N N 124 
ASN HD22 H N N 125 
ASN HXT  H N N 126 
ASP N    N N N 127 
ASP CA   C N S 128 
ASP C    C N N 129 
ASP O    O N N 130 
ASP CB   C N N 131 
ASP CG   C N N 132 
ASP OD1  O N N 133 
ASP OD2  O N N 134 
ASP OXT  O N N 135 
ASP H    H N N 136 
ASP H2   H N N 137 
ASP HA   H N N 138 
ASP HB2  H N N 139 
ASP HB3  H N N 140 
ASP HD2  H N N 141 
ASP HXT  H N N 142 
CYS N    N N N 143 
CYS CA   C N R 144 
CYS C    C N N 145 
CYS O    O N N 146 
CYS CB   C N N 147 
CYS SG   S N N 148 
CYS OXT  O N N 149 
CYS H    H N N 150 
CYS H2   H N N 151 
CYS HA   H N N 152 
CYS HB2  H N N 153 
CYS HB3  H N N 154 
CYS HG   H N N 155 
CYS HXT  H N N 156 
GLN N    N N N 157 
GLN CA   C N S 158 
GLN C    C N N 159 
GLN O    O N N 160 
GLN CB   C N N 161 
GLN CG   C N N 162 
GLN CD   C N N 163 
GLN OE1  O N N 164 
GLN NE2  N N N 165 
GLN OXT  O N N 166 
GLN H    H N N 167 
GLN H2   H N N 168 
GLN HA   H N N 169 
GLN HB2  H N N 170 
GLN HB3  H N N 171 
GLN HG2  H N N 172 
GLN HG3  H N N 173 
GLN HE21 H N N 174 
GLN HE22 H N N 175 
GLN HXT  H N N 176 
GLU N    N N N 177 
GLU CA   C N S 178 
GLU C    C N N 179 
GLU O    O N N 180 
GLU CB   C N N 181 
GLU CG   C N N 182 
GLU CD   C N N 183 
GLU OE1  O N N 184 
GLU OE2  O N N 185 
GLU OXT  O N N 186 
GLU H    H N N 187 
GLU H2   H N N 188 
GLU HA   H N N 189 
GLU HB2  H N N 190 
GLU HB3  H N N 191 
GLU HG2  H N N 192 
GLU HG3  H N N 193 
GLU HE2  H N N 194 
GLU HXT  H N N 195 
GLY N    N N N 196 
GLY CA   C N N 197 
GLY C    C N N 198 
GLY O    O N N 199 
GLY OXT  O N N 200 
GLY H    H N N 201 
GLY H2   H N N 202 
GLY HA2  H N N 203 
GLY HA3  H N N 204 
GLY HXT  H N N 205 
HIS N    N N N 206 
HIS CA   C N S 207 
HIS C    C N N 208 
HIS O    O N N 209 
HIS CB   C N N 210 
HIS CG   C Y N 211 
HIS ND1  N Y N 212 
HIS CD2  C Y N 213 
HIS CE1  C Y N 214 
HIS NE2  N Y N 215 
HIS OXT  O N N 216 
HIS H    H N N 217 
HIS H2   H N N 218 
HIS HA   H N N 219 
HIS HB2  H N N 220 
HIS HB3  H N N 221 
HIS HD1  H N N 222 
HIS HD2  H N N 223 
HIS HE1  H N N 224 
HIS HE2  H N N 225 
HIS HXT  H N N 226 
HOH O    O N N 227 
HOH H1   H N N 228 
HOH H2   H N N 229 
ILE N    N N N 230 
ILE CA   C N S 231 
ILE C    C N N 232 
ILE O    O N N 233 
ILE CB   C N S 234 
ILE CG1  C N N 235 
ILE CG2  C N N 236 
ILE CD1  C N N 237 
ILE OXT  O N N 238 
ILE H    H N N 239 
ILE H2   H N N 240 
ILE HA   H N N 241 
ILE HB   H N N 242 
ILE HG12 H N N 243 
ILE HG13 H N N 244 
ILE HG21 H N N 245 
ILE HG22 H N N 246 
ILE HG23 H N N 247 
ILE HD11 H N N 248 
ILE HD12 H N N 249 
ILE HD13 H N N 250 
ILE HXT  H N N 251 
LEU N    N N N 252 
LEU CA   C N S 253 
LEU C    C N N 254 
LEU O    O N N 255 
LEU CB   C N N 256 
LEU CG   C N N 257 
LEU CD1  C N N 258 
LEU CD2  C N N 259 
LEU OXT  O N N 260 
LEU H    H N N 261 
LEU H2   H N N 262 
LEU HA   H N N 263 
LEU HB2  H N N 264 
LEU HB3  H N N 265 
LEU HG   H N N 266 
LEU HD11 H N N 267 
LEU HD12 H N N 268 
LEU HD13 H N N 269 
LEU HD21 H N N 270 
LEU HD22 H N N 271 
LEU HD23 H N N 272 
LEU HXT  H N N 273 
LYS N    N N N 274 
LYS CA   C N S 275 
LYS C    C N N 276 
LYS O    O N N 277 
LYS CB   C N N 278 
LYS CG   C N N 279 
LYS CD   C N N 280 
LYS CE   C N N 281 
LYS NZ   N N N 282 
LYS OXT  O N N 283 
LYS H    H N N 284 
LYS H2   H N N 285 
LYS HA   H N N 286 
LYS HB2  H N N 287 
LYS HB3  H N N 288 
LYS HG2  H N N 289 
LYS HG3  H N N 290 
LYS HD2  H N N 291 
LYS HD3  H N N 292 
LYS HE2  H N N 293 
LYS HE3  H N N 294 
LYS HZ1  H N N 295 
LYS HZ2  H N N 296 
LYS HZ3  H N N 297 
LYS HXT  H N N 298 
MET N    N N N 299 
MET CA   C N S 300 
MET C    C N N 301 
MET O    O N N 302 
MET CB   C N N 303 
MET CG   C N N 304 
MET SD   S N N 305 
MET CE   C N N 306 
MET OXT  O N N 307 
MET H    H N N 308 
MET H2   H N N 309 
MET HA   H N N 310 
MET HB2  H N N 311 
MET HB3  H N N 312 
MET HG2  H N N 313 
MET HG3  H N N 314 
MET HE1  H N N 315 
MET HE2  H N N 316 
MET HE3  H N N 317 
MET HXT  H N N 318 
PHE N    N N N 319 
PHE CA   C N S 320 
PHE C    C N N 321 
PHE O    O N N 322 
PHE CB   C N N 323 
PHE CG   C Y N 324 
PHE CD1  C Y N 325 
PHE CD2  C Y N 326 
PHE CE1  C Y N 327 
PHE CE2  C Y N 328 
PHE CZ   C Y N 329 
PHE OXT  O N N 330 
PHE H    H N N 331 
PHE H2   H N N 332 
PHE HA   H N N 333 
PHE HB2  H N N 334 
PHE HB3  H N N 335 
PHE HD1  H N N 336 
PHE HD2  H N N 337 
PHE HE1  H N N 338 
PHE HE2  H N N 339 
PHE HZ   H N N 340 
PHE HXT  H N N 341 
PRO N    N N N 342 
PRO CA   C N S 343 
PRO C    C N N 344 
PRO O    O N N 345 
PRO CB   C N N 346 
PRO CG   C N N 347 
PRO CD   C N N 348 
PRO OXT  O N N 349 
PRO H    H N N 350 
PRO HA   H N N 351 
PRO HB2  H N N 352 
PRO HB3  H N N 353 
PRO HG2  H N N 354 
PRO HG3  H N N 355 
PRO HD2  H N N 356 
PRO HD3  H N N 357 
PRO HXT  H N N 358 
SER N    N N N 359 
SER CA   C N S 360 
SER C    C N N 361 
SER O    O N N 362 
SER CB   C N N 363 
SER OG   O N N 364 
SER OXT  O N N 365 
SER H    H N N 366 
SER H2   H N N 367 
SER HA   H N N 368 
SER HB2  H N N 369 
SER HB3  H N N 370 
SER HG   H N N 371 
SER HXT  H N N 372 
THR N    N N N 373 
THR CA   C N S 374 
THR C    C N N 375 
THR O    O N N 376 
THR CB   C N R 377 
THR OG1  O N N 378 
THR CG2  C N N 379 
THR OXT  O N N 380 
THR H    H N N 381 
THR H2   H N N 382 
THR HA   H N N 383 
THR HB   H N N 384 
THR HG1  H N N 385 
THR HG21 H N N 386 
THR HG22 H N N 387 
THR HG23 H N N 388 
THR HXT  H N N 389 
TRP N    N N N 390 
TRP CA   C N S 391 
TRP C    C N N 392 
TRP O    O N N 393 
TRP CB   C N N 394 
TRP CG   C Y N 395 
TRP CD1  C Y N 396 
TRP CD2  C Y N 397 
TRP NE1  N Y N 398 
TRP CE2  C Y N 399 
TRP CE3  C Y N 400 
TRP CZ2  C Y N 401 
TRP CZ3  C Y N 402 
TRP CH2  C Y N 403 
TRP OXT  O N N 404 
TRP H    H N N 405 
TRP H2   H N N 406 
TRP HA   H N N 407 
TRP HB2  H N N 408 
TRP HB3  H N N 409 
TRP HD1  H N N 410 
TRP HE1  H N N 411 
TRP HE3  H N N 412 
TRP HZ2  H N N 413 
TRP HZ3  H N N 414 
TRP HH2  H N N 415 
TRP HXT  H N N 416 
TYR N    N N N 417 
TYR CA   C N S 418 
TYR C    C N N 419 
TYR O    O N N 420 
TYR CB   C N N 421 
TYR CG   C Y N 422 
TYR CD1  C Y N 423 
TYR CD2  C Y N 424 
TYR CE1  C Y N 425 
TYR CE2  C Y N 426 
TYR CZ   C Y N 427 
TYR OH   O N N 428 
TYR OXT  O N N 429 
TYR H    H N N 430 
TYR H2   H N N 431 
TYR HA   H N N 432 
TYR HB2  H N N 433 
TYR HB3  H N N 434 
TYR HD1  H N N 435 
TYR HD2  H N N 436 
TYR HE1  H N N 437 
TYR HE2  H N N 438 
TYR HH   H N N 439 
TYR HXT  H N N 440 
VAL N    N N N 441 
VAL CA   C N S 442 
VAL C    C N N 443 
VAL O    O N N 444 
VAL CB   C N N 445 
VAL CG1  C N N 446 
VAL CG2  C N N 447 
VAL OXT  O N N 448 
VAL H    H N N 449 
VAL H2   H N N 450 
VAL HA   H N N 451 
VAL HB   H N N 452 
VAL HG11 H N N 453 
VAL HG12 H N N 454 
VAL HG13 H N N 455 
VAL HG21 H N N 456 
VAL HG22 H N N 457 
VAL HG23 H N N 458 
VAL HXT  H N N 459 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
4WI O1  C8   doub N N 1   
4WI C8  N2   sing N N 2   
4WI C8  C5   sing N N 3   
4WI N2  C7   sing N N 4   
4WI C4  C5   sing N N 5   
4WI C4  C2   sing N N 6   
4WI C5  C6   sing N N 7   
4WI N5  C3   doub N N 8   
4WI C3  C2   sing N N 9   
4WI C7  C6   sing N N 10  
4WI C2  N1   sing N N 11  
4WI N1  C1   sing N N 12  
4WI F1  C22  sing N N 13  
4WI O3  C13  doub N N 14  
4WI C1  C9   sing N N 15  
4WI C1  O2   doub N N 16  
4WI F3  C22  sing N N 17  
4WI C23 C15  sing N N 18  
4WI C22 F2   sing N N 19  
4WI C22 C21  sing N N 20  
4WI C9  N3   sing N N 21  
4WI C9  C12  sing N N 22  
4WI C13 N3   sing N N 23  
4WI C13 C14  sing N N 24  
4WI N4  C21  sing N N 25  
4WI N4  C14  sing N N 26  
4WI C19 C18  sing N N 27  
4WI N3  C10  sing N N 28  
4WI C21 O4   doub N N 29  
4WI C12 C18  sing N N 30  
4WI C12 C11  sing N N 31  
4WI C14 C15  sing N N 32  
4WI C15 C17  sing N N 33  
4WI C15 C16  sing N N 34  
4WI C18 C20  sing N N 35  
4WI C18 C11  sing N N 36  
4WI C10 C11  sing N N 37  
4WI C3  H33  sing N N 38  
4WI C6  H5   sing N N 39  
4WI C6  H6   sing N N 40  
4WI C7  H7   sing N N 41  
4WI C7  H8   sing N N 42  
4WI C10 H11  sing N N 43  
4WI C10 H12  sing N N 44  
4WI C5  H4   sing N N 45  
4WI C9  H10  sing N N 46  
4WI C11 H13  sing N N 47  
4WI C12 H14  sing N N 48  
4WI C19 H23  sing N N 49  
4WI C19 H24  sing N N 50  
4WI C19 H25  sing N N 51  
4WI C20 H26  sing N N 52  
4WI C20 H27  sing N N 53  
4WI C20 H28  sing N N 54  
4WI C16 H17  sing N N 55  
4WI C16 H19  sing N N 56  
4WI C16 H18  sing N N 57  
4WI C17 H20  sing N N 58  
4WI C17 H21  sing N N 59  
4WI C17 H22  sing N N 60  
4WI C23 H29  sing N N 61  
4WI C23 H30  sing N N 62  
4WI C23 H31  sing N N 63  
4WI C4  H2   sing N N 64  
4WI C4  H3   sing N N 65  
4WI C2  H32  sing N N 66  
4WI C14 H15  sing N N 67  
4WI N5  H36  sing N N 68  
4WI N2  H9   sing N N 69  
4WI N1  H1   sing N N 70  
4WI N4  H16  sing N N 71  
ALA N   CA   sing N N 72  
ALA N   H    sing N N 73  
ALA N   H2   sing N N 74  
ALA CA  C    sing N N 75  
ALA CA  CB   sing N N 76  
ALA CA  HA   sing N N 77  
ALA C   O    doub N N 78  
ALA C   OXT  sing N N 79  
ALA CB  HB1  sing N N 80  
ALA CB  HB2  sing N N 81  
ALA CB  HB3  sing N N 82  
ALA OXT HXT  sing N N 83  
ARG N   CA   sing N N 84  
ARG N   H    sing N N 85  
ARG N   H2   sing N N 86  
ARG CA  C    sing N N 87  
ARG CA  CB   sing N N 88  
ARG CA  HA   sing N N 89  
ARG C   O    doub N N 90  
ARG C   OXT  sing N N 91  
ARG CB  CG   sing N N 92  
ARG CB  HB2  sing N N 93  
ARG CB  HB3  sing N N 94  
ARG CG  CD   sing N N 95  
ARG CG  HG2  sing N N 96  
ARG CG  HG3  sing N N 97  
ARG CD  NE   sing N N 98  
ARG CD  HD2  sing N N 99  
ARG CD  HD3  sing N N 100 
ARG NE  CZ   sing N N 101 
ARG NE  HE   sing N N 102 
ARG CZ  NH1  sing N N 103 
ARG CZ  NH2  doub N N 104 
ARG NH1 HH11 sing N N 105 
ARG NH1 HH12 sing N N 106 
ARG NH2 HH21 sing N N 107 
ARG NH2 HH22 sing N N 108 
ARG OXT HXT  sing N N 109 
ASN N   CA   sing N N 110 
ASN N   H    sing N N 111 
ASN N   H2   sing N N 112 
ASN CA  C    sing N N 113 
ASN CA  CB   sing N N 114 
ASN CA  HA   sing N N 115 
ASN C   O    doub N N 116 
ASN C   OXT  sing N N 117 
ASN CB  CG   sing N N 118 
ASN CB  HB2  sing N N 119 
ASN CB  HB3  sing N N 120 
ASN CG  OD1  doub N N 121 
ASN CG  ND2  sing N N 122 
ASN ND2 HD21 sing N N 123 
ASN ND2 HD22 sing N N 124 
ASN OXT HXT  sing N N 125 
ASP N   CA   sing N N 126 
ASP N   H    sing N N 127 
ASP N   H2   sing N N 128 
ASP CA  C    sing N N 129 
ASP CA  CB   sing N N 130 
ASP CA  HA   sing N N 131 
ASP C   O    doub N N 132 
ASP C   OXT  sing N N 133 
ASP CB  CG   sing N N 134 
ASP CB  HB2  sing N N 135 
ASP CB  HB3  sing N N 136 
ASP CG  OD1  doub N N 137 
ASP CG  OD2  sing N N 138 
ASP OD2 HD2  sing N N 139 
ASP OXT HXT  sing N N 140 
CYS N   CA   sing N N 141 
CYS N   H    sing N N 142 
CYS N   H2   sing N N 143 
CYS CA  C    sing N N 144 
CYS CA  CB   sing N N 145 
CYS CA  HA   sing N N 146 
CYS C   O    doub N N 147 
CYS C   OXT  sing N N 148 
CYS CB  SG   sing N N 149 
CYS CB  HB2  sing N N 150 
CYS CB  HB3  sing N N 151 
CYS SG  HG   sing N N 152 
CYS OXT HXT  sing N N 153 
GLN N   CA   sing N N 154 
GLN N   H    sing N N 155 
GLN N   H2   sing N N 156 
GLN CA  C    sing N N 157 
GLN CA  CB   sing N N 158 
GLN CA  HA   sing N N 159 
GLN C   O    doub N N 160 
GLN C   OXT  sing N N 161 
GLN CB  CG   sing N N 162 
GLN CB  HB2  sing N N 163 
GLN CB  HB3  sing N N 164 
GLN CG  CD   sing N N 165 
GLN CG  HG2  sing N N 166 
GLN CG  HG3  sing N N 167 
GLN CD  OE1  doub N N 168 
GLN CD  NE2  sing N N 169 
GLN NE2 HE21 sing N N 170 
GLN NE2 HE22 sing N N 171 
GLN OXT HXT  sing N N 172 
GLU N   CA   sing N N 173 
GLU N   H    sing N N 174 
GLU N   H2   sing N N 175 
GLU CA  C    sing N N 176 
GLU CA  CB   sing N N 177 
GLU CA  HA   sing N N 178 
GLU C   O    doub N N 179 
GLU C   OXT  sing N N 180 
GLU CB  CG   sing N N 181 
GLU CB  HB2  sing N N 182 
GLU CB  HB3  sing N N 183 
GLU CG  CD   sing N N 184 
GLU CG  HG2  sing N N 185 
GLU CG  HG3  sing N N 186 
GLU CD  OE1  doub N N 187 
GLU CD  OE2  sing N N 188 
GLU OE2 HE2  sing N N 189 
GLU OXT HXT  sing N N 190 
GLY N   CA   sing N N 191 
GLY N   H    sing N N 192 
GLY N   H2   sing N N 193 
GLY CA  C    sing N N 194 
GLY CA  HA2  sing N N 195 
GLY CA  HA3  sing N N 196 
GLY C   O    doub N N 197 
GLY C   OXT  sing N N 198 
GLY OXT HXT  sing N N 199 
HIS N   CA   sing N N 200 
HIS N   H    sing N N 201 
HIS N   H2   sing N N 202 
HIS CA  C    sing N N 203 
HIS CA  CB   sing N N 204 
HIS CA  HA   sing N N 205 
HIS C   O    doub N N 206 
HIS C   OXT  sing N N 207 
HIS CB  CG   sing N N 208 
HIS CB  HB2  sing N N 209 
HIS CB  HB3  sing N N 210 
HIS CG  ND1  sing Y N 211 
HIS CG  CD2  doub Y N 212 
HIS ND1 CE1  doub Y N 213 
HIS ND1 HD1  sing N N 214 
HIS CD2 NE2  sing Y N 215 
HIS CD2 HD2  sing N N 216 
HIS CE1 NE2  sing Y N 217 
HIS CE1 HE1  sing N N 218 
HIS NE2 HE2  sing N N 219 
HIS OXT HXT  sing N N 220 
HOH O   H1   sing N N 221 
HOH O   H2   sing N N 222 
ILE N   CA   sing N N 223 
ILE N   H    sing N N 224 
ILE N   H2   sing N N 225 
ILE CA  C    sing N N 226 
ILE CA  CB   sing N N 227 
ILE CA  HA   sing N N 228 
ILE C   O    doub N N 229 
ILE C   OXT  sing N N 230 
ILE CB  CG1  sing N N 231 
ILE CB  CG2  sing N N 232 
ILE CB  HB   sing N N 233 
ILE CG1 CD1  sing N N 234 
ILE CG1 HG12 sing N N 235 
ILE CG1 HG13 sing N N 236 
ILE CG2 HG21 sing N N 237 
ILE CG2 HG22 sing N N 238 
ILE CG2 HG23 sing N N 239 
ILE CD1 HD11 sing N N 240 
ILE CD1 HD12 sing N N 241 
ILE CD1 HD13 sing N N 242 
ILE OXT HXT  sing N N 243 
LEU N   CA   sing N N 244 
LEU N   H    sing N N 245 
LEU N   H2   sing N N 246 
LEU CA  C    sing N N 247 
LEU CA  CB   sing N N 248 
LEU CA  HA   sing N N 249 
LEU C   O    doub N N 250 
LEU C   OXT  sing N N 251 
LEU CB  CG   sing N N 252 
LEU CB  HB2  sing N N 253 
LEU CB  HB3  sing N N 254 
LEU CG  CD1  sing N N 255 
LEU CG  CD2  sing N N 256 
LEU CG  HG   sing N N 257 
LEU CD1 HD11 sing N N 258 
LEU CD1 HD12 sing N N 259 
LEU CD1 HD13 sing N N 260 
LEU CD2 HD21 sing N N 261 
LEU CD2 HD22 sing N N 262 
LEU CD2 HD23 sing N N 263 
LEU OXT HXT  sing N N 264 
LYS N   CA   sing N N 265 
LYS N   H    sing N N 266 
LYS N   H2   sing N N 267 
LYS CA  C    sing N N 268 
LYS CA  CB   sing N N 269 
LYS CA  HA   sing N N 270 
LYS C   O    doub N N 271 
LYS C   OXT  sing N N 272 
LYS CB  CG   sing N N 273 
LYS CB  HB2  sing N N 274 
LYS CB  HB3  sing N N 275 
LYS CG  CD   sing N N 276 
LYS CG  HG2  sing N N 277 
LYS CG  HG3  sing N N 278 
LYS CD  CE   sing N N 279 
LYS CD  HD2  sing N N 280 
LYS CD  HD3  sing N N 281 
LYS CE  NZ   sing N N 282 
LYS CE  HE2  sing N N 283 
LYS CE  HE3  sing N N 284 
LYS NZ  HZ1  sing N N 285 
LYS NZ  HZ2  sing N N 286 
LYS NZ  HZ3  sing N N 287 
LYS OXT HXT  sing N N 288 
MET N   CA   sing N N 289 
MET N   H    sing N N 290 
MET N   H2   sing N N 291 
MET CA  C    sing N N 292 
MET CA  CB   sing N N 293 
MET CA  HA   sing N N 294 
MET C   O    doub N N 295 
MET C   OXT  sing N N 296 
MET CB  CG   sing N N 297 
MET CB  HB2  sing N N 298 
MET CB  HB3  sing N N 299 
MET CG  SD   sing N N 300 
MET CG  HG2  sing N N 301 
MET CG  HG3  sing N N 302 
MET SD  CE   sing N N 303 
MET CE  HE1  sing N N 304 
MET CE  HE2  sing N N 305 
MET CE  HE3  sing N N 306 
MET OXT HXT  sing N N 307 
PHE N   CA   sing N N 308 
PHE N   H    sing N N 309 
PHE N   H2   sing N N 310 
PHE CA  C    sing N N 311 
PHE CA  CB   sing N N 312 
PHE CA  HA   sing N N 313 
PHE C   O    doub N N 314 
PHE C   OXT  sing N N 315 
PHE CB  CG   sing N N 316 
PHE CB  HB2  sing N N 317 
PHE CB  HB3  sing N N 318 
PHE CG  CD1  doub Y N 319 
PHE CG  CD2  sing Y N 320 
PHE CD1 CE1  sing Y N 321 
PHE CD1 HD1  sing N N 322 
PHE CD2 CE2  doub Y N 323 
PHE CD2 HD2  sing N N 324 
PHE CE1 CZ   doub Y N 325 
PHE CE1 HE1  sing N N 326 
PHE CE2 CZ   sing Y N 327 
PHE CE2 HE2  sing N N 328 
PHE CZ  HZ   sing N N 329 
PHE OXT HXT  sing N N 330 
PRO N   CA   sing N N 331 
PRO N   CD   sing N N 332 
PRO N   H    sing N N 333 
PRO CA  C    sing N N 334 
PRO CA  CB   sing N N 335 
PRO CA  HA   sing N N 336 
PRO C   O    doub N N 337 
PRO C   OXT  sing N N 338 
PRO CB  CG   sing N N 339 
PRO CB  HB2  sing N N 340 
PRO CB  HB3  sing N N 341 
PRO CG  CD   sing N N 342 
PRO CG  HG2  sing N N 343 
PRO CG  HG3  sing N N 344 
PRO CD  HD2  sing N N 345 
PRO CD  HD3  sing N N 346 
PRO OXT HXT  sing N N 347 
SER N   CA   sing N N 348 
SER N   H    sing N N 349 
SER N   H2   sing N N 350 
SER CA  C    sing N N 351 
SER CA  CB   sing N N 352 
SER CA  HA   sing N N 353 
SER C   O    doub N N 354 
SER C   OXT  sing N N 355 
SER CB  OG   sing N N 356 
SER CB  HB2  sing N N 357 
SER CB  HB3  sing N N 358 
SER OG  HG   sing N N 359 
SER OXT HXT  sing N N 360 
THR N   CA   sing N N 361 
THR N   H    sing N N 362 
THR N   H2   sing N N 363 
THR CA  C    sing N N 364 
THR CA  CB   sing N N 365 
THR CA  HA   sing N N 366 
THR C   O    doub N N 367 
THR C   OXT  sing N N 368 
THR CB  OG1  sing N N 369 
THR CB  CG2  sing N N 370 
THR CB  HB   sing N N 371 
THR OG1 HG1  sing N N 372 
THR CG2 HG21 sing N N 373 
THR CG2 HG22 sing N N 374 
THR CG2 HG23 sing N N 375 
THR OXT HXT  sing N N 376 
TRP N   CA   sing N N 377 
TRP N   H    sing N N 378 
TRP N   H2   sing N N 379 
TRP CA  C    sing N N 380 
TRP CA  CB   sing N N 381 
TRP CA  HA   sing N N 382 
TRP C   O    doub N N 383 
TRP C   OXT  sing N N 384 
TRP CB  CG   sing N N 385 
TRP CB  HB2  sing N N 386 
TRP CB  HB3  sing N N 387 
TRP CG  CD1  doub Y N 388 
TRP CG  CD2  sing Y N 389 
TRP CD1 NE1  sing Y N 390 
TRP CD1 HD1  sing N N 391 
TRP CD2 CE2  doub Y N 392 
TRP CD2 CE3  sing Y N 393 
TRP NE1 CE2  sing Y N 394 
TRP NE1 HE1  sing N N 395 
TRP CE2 CZ2  sing Y N 396 
TRP CE3 CZ3  doub Y N 397 
TRP CE3 HE3  sing N N 398 
TRP CZ2 CH2  doub Y N 399 
TRP CZ2 HZ2  sing N N 400 
TRP CZ3 CH2  sing Y N 401 
TRP CZ3 HZ3  sing N N 402 
TRP CH2 HH2  sing N N 403 
TRP OXT HXT  sing N N 404 
TYR N   CA   sing N N 405 
TYR N   H    sing N N 406 
TYR N   H2   sing N N 407 
TYR CA  C    sing N N 408 
TYR CA  CB   sing N N 409 
TYR CA  HA   sing N N 410 
TYR C   O    doub N N 411 
TYR C   OXT  sing N N 412 
TYR CB  CG   sing N N 413 
TYR CB  HB2  sing N N 414 
TYR CB  HB3  sing N N 415 
TYR CG  CD1  doub Y N 416 
TYR CG  CD2  sing Y N 417 
TYR CD1 CE1  sing Y N 418 
TYR CD1 HD1  sing N N 419 
TYR CD2 CE2  doub Y N 420 
TYR CD2 HD2  sing N N 421 
TYR CE1 CZ   doub Y N 422 
TYR CE1 HE1  sing N N 423 
TYR CE2 CZ   sing Y N 424 
TYR CE2 HE2  sing N N 425 
TYR CZ  OH   sing N N 426 
TYR OH  HH   sing N N 427 
TYR OXT HXT  sing N N 428 
VAL N   CA   sing N N 429 
VAL N   H    sing N N 430 
VAL N   H2   sing N N 431 
VAL CA  C    sing N N 432 
VAL CA  CB   sing N N 433 
VAL CA  HA   sing N N 434 
VAL C   O    doub N N 435 
VAL C   OXT  sing N N 436 
VAL CB  CG1  sing N N 437 
VAL CB  CG2  sing N N 438 
VAL CB  HB   sing N N 439 
VAL CG1 HG11 sing N N 440 
VAL CG1 HG12 sing N N 441 
VAL CG1 HG13 sing N N 442 
VAL CG2 HG21 sing N N 443 
VAL CG2 HG22 sing N N 444 
VAL CG2 HG23 sing N N 445 
VAL OXT HXT  sing N N 446 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' 'P30 GM133893' 1 
'Department of Energy (DOE, United States)'                                                'United States' KP1607011      2 
'Other government'                                                                         ?               DE-SC0012704   3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6Y2F 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 2' 
_space_group.name_Hall        'P 2 2ab' 
_space_group.IT_number        18 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9BO6 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.022040 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.015783 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009458 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
F ? ? 4.90428 4.07044 ? ? 12.99538 1.63651  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . SER A 1 1   ? 15.87456  38.00880 -21.67978 1.000 22.57058 ? 1   SER A N   1 
ATOM   2    C CA  . SER A 1 1   ? 15.30707  37.53786 -20.41595 1.000 20.55217 ? 1   SER A CA  1 
ATOM   3    C C   . SER A 1 1   ? 13.81008  37.67142 -20.40859 1.000 23.56630 ? 1   SER A C   1 
ATOM   4    O O   . SER A 1 1   ? 13.20541  38.19864 -21.36693 1.000 22.66175 ? 1   SER A O   1 
ATOM   5    C CB  . SER A 1 1   ? 15.90238  38.30348 -19.22108 1.000 23.97028 ? 1   SER A CB  1 
ATOM   6    O OG  . SER A 1 1   ? 17.29504  38.06166 -19.19060 1.000 37.12307 ? 1   SER A OG  1 
ATOM   7    N N   . GLY A 1 2   ? 13.22034  37.20801 -19.30972 1.000 22.28251 ? 2   GLY A N   1 
ATOM   8    C CA  . GLY A 1 2   ? 11.77951  36.96803 -19.24715 1.000 25.79805 ? 2   GLY A CA  1 
ATOM   9    C C   . GLY A 1 2   ? 11.43574  35.54277 -19.63908 1.000 22.57735 ? 2   GLY A C   1 
ATOM   10   O O   . GLY A 1 2   ? 12.12873  34.89182 -20.41365 1.000 24.29810 ? 2   GLY A O   1 
ATOM   11   N N   . PHE A 1 3   ? 10.36158  35.02631 -19.05509 1.000 22.77701 ? 3   PHE A N   1 
ATOM   12   C CA  . PHE A 1 3   ? 9.94259   33.66298 -19.34933 1.000 22.94097 ? 3   PHE A CA  1 
ATOM   13   C C   . PHE A 1 3   ? 8.42146   33.61835 -19.37161 1.000 20.62584 ? 3   PHE A C   1 
ATOM   14   O O   . PHE A 1 3   ? 7.77792   33.97074 -18.37978 1.000 23.95610 ? 3   PHE A O   1 
ATOM   15   C CB  . PHE A 1 3   ? 10.51940  32.67859 -18.31881 1.000 24.43983 ? 3   PHE A CB  1 
ATOM   16   C CG  . PHE A 1 3   ? 10.53999  31.27334 -18.80911 1.000 17.33877 ? 3   PHE A CG  1 
ATOM   17   C CD1 . PHE A 1 3   ? 11.47426  30.86783 -19.74304 1.000 20.11533 ? 3   PHE A CD1 1 
ATOM   18   C CD2 . PHE A 1 3   ? 9.57259   30.38163 -18.39479 1.000 22.66692 ? 3   PHE A CD2 1 
ATOM   19   C CE1 . PHE A 1 3   ? 11.47705  29.56887 -20.20620 1.000 22.02276 ? 3   PHE A CE1 1 
ATOM   20   C CE2 . PHE A 1 3   ? 9.56411   29.08772 -18.85398 1.000 21.49927 ? 3   PHE A CE2 1 
ATOM   21   C CZ  . PHE A 1 3   ? 10.49962  28.67853 -19.75458 1.000 21.83620 ? 3   PHE A CZ  1 
ATOM   22   N N   . ARG A 1 4   ? 7.85573   33.22304 -20.50423 1.000 20.75954 ? 4   ARG A N   1 
ATOM   23   C CA  . ARG A 1 4   ? 6.42606   33.26305 -20.74921 1.000 21.07312 ? 4   ARG A CA  1 
ATOM   24   C C   . ARG A 1 4   ? 5.94355   31.90634 -21.22855 1.000 19.08804 ? 4   ARG A C   1 
ATOM   25   O O   . ARG A 1 4   ? 6.66570   31.17659 -21.89440 1.000 22.71612 ? 4   ARG A O   1 
ATOM   26   C CB  . ARG A 1 4   ? 6.09157   34.29221 -21.83574 1.000 21.60102 ? 4   ARG A CB  1 
ATOM   27   C CG  . ARG A 1 4   ? 6.01973   35.68619 -21.33335 1.000 27.09999 ? 4   ARG A CG  1 
ATOM   28   C CD  . ARG A 1 4   ? 4.62182   35.89082 -20.76148 1.000 36.14764 ? 4   ARG A CD  1 
ATOM   29   N NE  . ARG A 1 4   ? 4.32633   37.30412 -20.66776 1.000 39.34890 ? 4   ARG A NE  1 
ATOM   30   C CZ  . ARG A 1 4   ? 3.21933   37.77892 -20.12720 1.000 43.91213 ? 4   ARG A CZ  1 
ATOM   31   N NH1 . ARG A 1 4   ? 2.21749   36.97612 -19.81173 1.000 40.14900 ? 4   ARG A NH1 1 
ATOM   32   N NH2 . ARG A 1 4   ? 3.12906   39.08330 -19.86981 1.000 27.10279 ? 4   ARG A NH2 1 
ATOM   33   N N   . LYS A 1 5   ? 4.69666   31.57895 -20.92428 1.000 20.64885 ? 5   LYS A N   1 
ATOM   34   C CA  . LYS A 1 5   ? 4.11762   30.43622 -21.60154 1.000 19.81636 ? 5   LYS A CA  1 
ATOM   35   C C   . LYS A 1 5   ? 3.96836   30.82878 -23.06948 1.000 25.40291 ? 5   LYS A C   1 
ATOM   36   O O   . LYS A 1 5   ? 3.32578   31.83307 -23.38562 1.000 28.73265 ? 5   LYS A O   1 
ATOM   37   C CB  . LYS A 1 5   ? 2.78631   30.06770 -20.94040 1.000 20.88816 ? 5   LYS A CB  1 
ATOM   38   C CG  . LYS A 1 5   ? 2.16018   28.72897 -21.37598 1.000 26.11900 ? 5   LYS A CG  1 
ATOM   39   C CD  . LYS A 1 5   ? 2.99522   27.50095 -20.99894 1.000 26.37902 ? 5   LYS A CD  1 
ATOM   40   C CE  . LYS A 1 5   ? 3.09381   27.33931 -19.50263 1.000 38.17793 ? 5   LYS A CE  1 
ATOM   41   N NZ  . LYS A 1 5   ? 1.72949   27.22500 -18.94992 1.000 33.53474 ? 5   LYS A NZ  1 
ATOM   42   N N   . MET A 1 6   ? 4.63782   30.10706 -23.94929 1.000 18.66228 ? 6   MET A N   1 
ATOM   43   C CA  . MET A 1 6   ? 4.77192   30.48316 -25.34882 1.000 22.16283 ? 6   MET A CA  1 
ATOM   44   C C   . MET A 1 6   ? 4.18084   29.36741 -26.19092 1.000 23.07275 ? 6   MET A C   1 
ATOM   45   O O   . MET A 1 6   ? 4.42814   28.19387 -25.90642 1.000 22.25189 ? 6   MET A O   1 
ATOM   46   C CB  . MET A 1 6   ? 6.26184   30.67228 -25.64880 1.000 26.04907 ? 6   MET A CB  1 
ATOM   47   C CG  . MET A 1 6   ? 6.60848   31.21904 -26.97280 1.000 31.64727 ? 6   MET A CG  1 
ATOM   48   S SD  . MET A 1 6   ? 8.38857   31.51963 -26.89574 1.000 41.11215 ? 6   MET A SD  1 
ATOM   49   C CE  . MET A 1 6   ? 8.46010   32.89594 -25.77532 1.000 31.06159 ? 6   MET A CE  1 
ATOM   50   N N   . ALA A 1 7   ? 3.39673   29.72316 -27.21354 1.000 20.43327 ? 7   ALA A N   1 
ATOM   51   C CA  . ALA A 1 7   ? 2.86518   28.75132 -28.15978 1.000 19.66801 ? 7   ALA A CA  1 
ATOM   52   C C   . ALA A 1 7   ? 3.72905   28.76827 -29.41648 1.000 18.23095 ? 7   ALA A C   1 
ATOM   53   O O   . ALA A 1 7   ? 4.48131   29.71229 -29.65365 1.000 20.54446 ? 7   ALA A O   1 
ATOM   54   C CB  . ALA A 1 7   ? 1.41504   29.09304 -28.51149 1.000 17.54901 ? 7   ALA A CB  1 
ATOM   55   N N   . PHE A 1 8   ? 3.69395   27.67508 -30.16600 1.000 19.65279 ? 8   PHE A N   1 
ATOM   56   C CA  . PHE A 1 8   ? 4.28098   27.71224 -31.49608 1.000 19.51224 ? 8   PHE A CA  1 
ATOM   57   C C   . PHE A 1 8   ? 3.51432   28.68931 -32.37559 1.000 20.47798 ? 8   PHE A C   1 
ATOM   58   O O   . PHE A 1 8   ? 2.30134   28.85173 -32.23933 1.000 21.24572 ? 8   PHE A O   1 
ATOM   59   C CB  . PHE A 1 8   ? 4.25572   26.33668 -32.14743 1.000 19.36826 ? 8   PHE A CB  1 
ATOM   60   C CG  . PHE A 1 8   ? 5.20246   25.34782 -31.53565 1.000 23.81829 ? 8   PHE A CG  1 
ATOM   61   C CD1 . PHE A 1 8   ? 6.52608   25.32243 -31.91804 1.000 23.22734 ? 8   PHE A CD1 1 
ATOM   62   C CD2 . PHE A 1 8   ? 4.74074   24.42860 -30.60304 1.000 22.79623 ? 8   PHE A CD2 1 
ATOM   63   C CE1 . PHE A 1 8   ? 7.41604   24.41336 -31.32623 1.000 25.81206 ? 8   PHE A CE1 1 
ATOM   64   C CE2 . PHE A 1 8   ? 5.60708   23.50262 -30.03776 1.000 32.25381 ? 8   PHE A CE2 1 
ATOM   65   C CZ  . PHE A 1 8   ? 6.93256   23.48363 -30.40244 1.000 26.75174 ? 8   PHE A CZ  1 
ATOM   66   N N   . PRO A 1 9   ? 4.20184   29.35978 -33.28870 1.000 22.54750 ? 9   PRO A N   1 
ATOM   67   C CA  . PRO A 1 9   ? 3.48525   30.12405 -34.32153 1.000 21.30945 ? 9   PRO A CA  1 
ATOM   68   C C   . PRO A 1 9   ? 2.51968   29.19991 -35.04245 1.000 22.03497 ? 9   PRO A C   1 
ATOM   69   O O   . PRO A 1 9   ? 2.88102   28.07677 -35.40797 1.000 24.28370 ? 9   PRO A O   1 
ATOM   70   C CB  . PRO A 1 9   ? 4.60234   30.61393 -35.25529 1.000 23.12618 ? 9   PRO A CB  1 
ATOM   71   C CG  . PRO A 1 9   ? 5.79694   29.71064 -34.92884 1.000 34.42133 ? 9   PRO A CG  1 
ATOM   72   C CD  . PRO A 1 9   ? 5.66103   29.34119 -33.48264 1.000 25.56717 ? 9   PRO A CD  1 
ATOM   73   N N   . SER A 1 10  ? 1.29965   29.69290 -35.24935 1.000 20.31414 ? 10  SER A N   1 
ATOM   74   C CA  . SER A 1 10  ? 0.16070   28.87158 -35.67029 1.000 18.75002 ? 10  SER A CA  1 
ATOM   75   C C   . SER A 1 10  ? -0.09230  28.89936 -37.16012 1.000 19.96651 ? 10  SER A C   1 
ATOM   76   O O   . SER A 1 10  ? -0.95079  28.14539 -37.63116 1.000 20.87320 ? 10  SER A O   1 
ATOM   77   C CB  . SER A 1 10  ? -1.14711  29.27175 -34.95197 1.000 21.46137 ? 10  SER A CB  1 
ATOM   78   O OG  . SER A 1 10  ? -1.49703  30.64440 -35.09238 1.000 21.24502 ? 10  SER A OG  1 
ATOM   79   N N   . GLY A 1 11  ? 0.63145   29.72613 -37.90905 1.000 22.37785 ? 11  GLY A N   1 
ATOM   80   C CA  . GLY A 1 11  ? 0.26336   29.95739 -39.30373 1.000 21.39692 ? 11  GLY A CA  1 
ATOM   81   C C   . GLY A 1 11  ? 0.24618   28.69740 -40.15611 1.000 23.37359 ? 11  GLY A C   1 
ATOM   82   O O   . GLY A 1 11  ? -0.62914  28.53761 -41.01210 1.000 21.44269 ? 11  GLY A O   1 
ATOM   83   N N   . LYS A 1 12  ? 1.20598   27.78965 -39.94366 1.000 22.73266 ? 12  LYS A N   1 
ATOM   84   C CA  . LYS A 1 12  ? 1.24234   26.57358 -40.75503 1.000 21.47998 ? 12  LYS A CA  1 
ATOM   85   C C   . LYS A 1 12  ? -0.03103  25.76265 -40.55438 1.000 23.39129 ? 12  LYS A C   1 
ATOM   86   O O   . LYS A 1 12  ? -0.56051  25.17070 -41.50711 1.000 22.86466 ? 12  LYS A O   1 
ATOM   87   C CB  . LYS A 1 12  ? 2.47815   25.72592 -40.42343 1.000 23.23338 ? 12  LYS A CB  1 
ATOM   88   C CG  . LYS A 1 12  ? 3.80685   26.29010 -40.95512 1.000 26.06356 ? 12  LYS A CG  1 
ATOM   89   C CD  . LYS A 1 12  ? 4.95683   25.37536 -40.57473 1.000 32.30919 ? 12  LYS A CD  1 
ATOM   90   C CE  . LYS A 1 12  ? 6.28707   25.98161 -40.98683 1.000 47.22928 ? 12  LYS A CE  1 
ATOM   91   N NZ  . LYS A 1 12  ? 6.49603   25.81109 -42.43747 1.000 37.88091 ? 12  LYS A NZ  1 
ATOM   92   N N   . VAL A 1 13  ? -0.56124  25.75661 -39.32324 1.000 19.13175 ? 13  VAL A N   1 
ATOM   93   C CA  . VAL A 1 13  ? -1.79547  25.02800 -39.02006 1.000 21.42115 ? 13  VAL A CA  1 
ATOM   94   C C   . VAL A 1 13  ? -3.02823  25.81443 -39.46785 1.000 20.97416 ? 13  VAL A C   1 
ATOM   95   O O   . VAL A 1 13  ? -4.02023  25.22920 -39.91314 1.000 20.22994 ? 13  VAL A O   1 
ATOM   96   C CB  . VAL A 1 13  ? -1.81942  24.69077 -37.50222 1.000 20.22203 ? 13  VAL A CB  1 
ATOM   97   C CG1 . VAL A 1 13  ? -3.10646  23.95094 -37.10628 1.000 20.41167 ? 13  VAL A CG1 1 
ATOM   98   C CG2 . VAL A 1 13  ? -0.62373  23.81857 -37.12974 1.000 18.34953 ? 13  VAL A CG2 1 
ATOM   99   N N   . GLU A 1 14  ? -3.01442  27.14123 -39.32566 1.000 17.48749 ? 14  GLU A N   1 
ATOM   100  C CA  . GLU A 1 14  ? -4.12615  27.94964 -39.82624 1.000 17.76384 ? 14  GLU A CA  1 
ATOM   101  C C   . GLU A 1 14  ? -4.42915  27.66313 -41.28586 1.000 18.79637 ? 14  GLU A C   1 
ATOM   102  O O   . GLU A 1 14  ? -5.60213  27.63225 -41.68052 1.000 20.80024 ? 14  GLU A O   1 
ATOM   103  C CB  . GLU A 1 14  ? -3.81650  29.43571 -39.68508 1.000 21.31849 ? 14  GLU A CB  1 
ATOM   104  C CG  . GLU A 1 14  ? -3.76412  29.90359 -38.22499 1.000 20.16435 ? 14  GLU A CG  1 
ATOM   105  C CD  . GLU A 1 14  ? -3.21042  31.31419 -38.10069 1.000 24.46884 ? 14  GLU A CD  1 
ATOM   106  O OE1 . GLU A 1 14  ? -3.73948  32.21230 -38.79458 1.000 25.76399 ? 14  GLU A OE1 1 
ATOM   107  O OE2 . GLU A 1 14  ? -2.23496  31.51134 -37.32977 1.000 25.68792 ? 14  GLU A OE2 1 
ATOM   108  N N   . GLY A 1 15  ? -3.39303  27.47814 -42.09485 1.000 21.59831 ? 15  GLY A N   1 
ATOM   109  C CA  . GLY A 1 15  ? -3.62269  27.25730 -43.51895 1.000 21.59131 ? 15  GLY A CA  1 
ATOM   110  C C   . GLY A 1 15  ? -4.24492  25.91699 -43.82529 1.000 25.95620 ? 15  GLY A C   1 
ATOM   111  O O   . GLY A 1 15  ? -4.55624  25.64343 -44.98797 1.000 24.81497 ? 15  GLY A O   1 
ATOM   112  N N   . CYS A 1 16  ? -4.43616  25.07832 -42.80351 1.000 20.31870 ? 16  CYS A N   1 
ATOM   113  C CA  . CYS A 1 16  ? -5.03732  23.76190 -42.94188 1.000 18.87817 ? 16  CYS A CA  1 
ATOM   114  C C   . CYS A 1 16  ? -6.42944  23.65792 -42.34781 1.000 23.06765 ? 16  CYS A C   1 
ATOM   115  O O   . CYS A 1 16  ? -7.03181  22.59094 -42.44362 1.000 23.50710 ? 16  CYS A O   1 
ATOM   116  C CB  . CYS A 1 16  ? -4.17732  22.69961 -42.25915 1.000 18.47485 ? 16  CYS A CB  1 
ATOM   117  S SG  . CYS A 1 16  ? -2.47681  22.58563 -42.88535 1.000 23.79244 ? 16  CYS A SG  1 
ATOM   118  N N   . MET A 1 17  ? -6.95359  24.68991 -41.70349 1.000 18.56950 ? 17  MET A N   1 
ATOM   119  C CA  . MET A 1 17  ? -8.26055  24.52882 -41.08753 1.000 19.10441 ? 17  MET A CA  1 
ATOM   120  C C   . MET A 1 17  ? -9.40761  24.76042 -42.05736 1.000 21.80948 ? 17  MET A C   1 
ATOM   121  O O   . MET A 1 17  ? -9.37733  25.68896 -42.86433 1.000 22.13301 ? 17  MET A O   1 
ATOM   122  C CB  . MET A 1 17  ? -8.40417  25.47766 -39.90088 1.000 17.24375 ? 17  MET A CB  1 
ATOM   123  C CG  . MET A 1 17  ? -7.32390  25.21416 -38.85112 1.000 20.36315 ? 17  MET A CG  1 
ATOM   124  S SD  . MET A 1 17  ? -7.20890  23.53486 -38.20601 1.000 21.93252 ? 17  MET A SD  1 
ATOM   125  C CE  . MET A 1 17  ? -8.91410  23.18668 -37.73665 1.000 20.21164 ? 17  MET A CE  1 
ATOM   126  N N   . VAL A 1 18  ? -10.41272 23.89291 -41.97630 1.000 19.62561 ? 18  VAL A N   1 
ATOM   127  C CA  . VAL A 1 18  ? -11.63035 24.01539 -42.77302 1.000 19.97276 ? 18  VAL A CA  1 
ATOM   128  C C   . VAL A 1 18  ? -12.83757 23.73681 -41.89416 1.000 22.82895 ? 18  VAL A C   1 
ATOM   129  O O   . VAL A 1 18  ? -12.72505 23.22264 -40.78001 1.000 21.33679 ? 18  VAL A O   1 
ATOM   130  C CB  . VAL A 1 18  ? -11.63600 23.05409 -43.98946 1.000 17.98991 ? 18  VAL A CB  1 
ATOM   131  C CG1 . VAL A 1 18  ? -10.44345 23.35165 -44.85226 1.000 22.60370 ? 18  VAL A CG1 1 
ATOM   132  C CG2 . VAL A 1 18  ? -11.58511 21.61223 -43.53485 1.000 19.98970 ? 18  VAL A CG2 1 
ATOM   133  N N   . GLN A 1 19  ? -14.00612 24.06693 -42.44477 1.000 21.13620 ? 19  GLN A N   1 
ATOM   134  C CA  . GLN A 1 19  ? -15.30144 23.80146 -41.83368 1.000 22.91314 ? 19  GLN A CA  1 
ATOM   135  C C   . GLN A 1 19  ? -15.90476 22.54482 -42.45805 1.000 24.07174 ? 19  GLN A C   1 
ATOM   136  O O   . GLN A 1 19  ? -15.86623 22.38696 -43.68093 1.000 25.94473 ? 19  GLN A O   1 
ATOM   137  C CB  . GLN A 1 19  ? -16.21871 24.99339 -42.06675 1.000 28.01146 ? 19  GLN A CB  1 
ATOM   138  C CG  . GLN A 1 19  ? -17.55746 24.90175 -41.39202 1.000 32.86861 ? 19  GLN A CG  1 
ATOM   139  C CD  . GLN A 1 19  ? -18.30611 26.21341 -41.50968 1.000 29.08640 ? 19  GLN A CD  1 
ATOM   140  O OE1 . GLN A 1 19  ? -19.10582 26.56785 -40.64933 1.000 46.45407 ? 19  GLN A OE1 1 
ATOM   141  N NE2 . GLN A 1 19  ? -18.02449 26.95356 -42.58242 1.000 42.15826 ? 19  GLN A NE2 1 
ATOM   142  N N   . VAL A 1 20  ? -16.41724 21.64220 -41.62929 1.000 19.94596 ? 20  VAL A N   1 
ATOM   143  C CA  . VAL A 1 20  ? -17.09296 20.43169 -42.11297 1.000 22.29245 ? 20  VAL A CA  1 
ATOM   144  C C   . VAL A 1 20  ? -18.50554 20.43027 -41.56313 1.000 23.40188 ? 20  VAL A C   1 
ATOM   145  O O   . VAL A 1 20  ? -18.70453 20.46217 -40.34224 1.000 24.33395 ? 20  VAL A O   1 
ATOM   146  C CB  . VAL A 1 20  ? -16.36593 19.15143 -41.68654 1.000 25.71924 ? 20  VAL A CB  1 
ATOM   147  C CG1 . VAL A 1 20  ? -17.13516 17.86929 -42.16804 1.000 21.71893 ? 20  VAL A CG1 1 
ATOM   148  C CG2 . VAL A 1 20  ? -14.89187 19.18776 -42.13951 1.000 20.71742 ? 20  VAL A CG2 1 
ATOM   149  N N   . THR A 1 21  ? -19.48318 20.33238 -42.45555 1.000 22.84251 ? 21  THR A N   1 
ATOM   150  C CA  . THR A 1 21  ? -20.88492 20.31667 -42.05990 1.000 26.59452 ? 21  THR A CA  1 
ATOM   151  C C   . THR A 1 21  ? -21.51676 19.04012 -42.58082 1.000 24.55356 ? 21  THR A C   1 
ATOM   152  O O   . THR A 1 21  ? -21.38033 18.71066 -43.76600 1.000 25.97266 ? 21  THR A O   1 
ATOM   153  C CB  . THR A 1 21  ? -21.62824 21.54008 -42.60391 1.000 26.22401 ? 21  THR A CB  1 
ATOM   154  O OG1 . THR A 1 21  ? -21.00072 22.73334 -42.11266 1.000 28.18844 ? 21  THR A OG1 1 
ATOM   155  C CG2 . THR A 1 21  ? -23.07689 21.52282 -42.13872 1.000 30.38571 ? 21  THR A CG2 1 
ATOM   156  N N   . CYS A 1 22  ? -22.22460 18.33624 -41.70742 1.000 26.39420 ? 22  CYS A N   1 
ATOM   157  C CA  . CYS A 1 22  ? -23.01321 17.18792 -42.12147 1.000 21.82758 ? 22  CYS A CA  1 
ATOM   158  C C   . CYS A 1 22  ? -24.38612 17.37380 -41.49606 1.000 24.61181 ? 22  CYS A C   1 
ATOM   159  O O   . CYS A 1 22  ? -24.50957 17.46498 -40.26530 1.000 27.02720 ? 22  CYS A O   1 
ATOM   160  C CB  . CYS A 1 22  ? -22.33635 15.88055 -41.69623 1.000 29.97822 ? 22  CYS A CB  1 
ATOM   161  S SG  . CYS A 1 22  ? -23.10998 14.37533 -42.32112 1.000 42.96690 ? 22  CYS A SG  1 
ATOM   162  N N   . GLY A 1 23  ? -25.39574 17.50683 -42.34425 1.000 38.61716 ? 23  GLY A N   1 
ATOM   163  C CA  . GLY A 1 23  ? -26.72453 17.82712 -41.85341 1.000 37.42005 ? 23  GLY A CA  1 
ATOM   164  C C   . GLY A 1 23  ? -26.70334 19.20822 -41.24399 1.000 30.38212 ? 23  GLY A C   1 
ATOM   165  O O   . GLY A 1 23  ? -26.42590 20.21353 -41.91098 1.000 42.50495 ? 23  GLY A O   1 
ATOM   166  N N   . THR A 1 24  ? -26.97828 19.28213 -39.94812 1.000 33.11830 ? 24  THR A N   1 
ATOM   167  C CA  . THR A 1 24  ? -26.94136 20.54127 -39.23075 1.000 33.23328 ? 24  THR A CA  1 
ATOM   168  C C   . THR A 1 24  ? -25.78117 20.62569 -38.25192 1.000 38.23077 ? 24  THR A C   1 
ATOM   169  O O   . THR A 1 24  ? -25.70574 21.58286 -37.47717 1.000 39.07446 ? 24  THR A O   1 
ATOM   170  C CB  . THR A 1 24  ? -28.25979 20.74613 -38.48459 1.000 42.88940 ? 24  THR A CB  1 
ATOM   171  O OG1 . THR A 1 24  ? -28.53950 19.57315 -37.70222 1.000 40.24356 ? 24  THR A OG1 1 
ATOM   172  C CG2 . THR A 1 24  ? -29.37346 20.96721 -39.48390 1.000 40.55348 ? 24  THR A CG2 1 
ATOM   173  N N   . THR A 1 25  ? -24.89279 19.64088 -38.24803 1.000 31.03942 ? 25  THR A N   1 
ATOM   174  C CA  . THR A 1 25  ? -23.76411 19.62299 -37.33674 1.000 26.99280 ? 25  THR A CA  1 
ATOM   175  C C   . THR A 1 25  ? -22.56056 20.18739 -38.08168 1.000 29.77322 ? 25  THR A C   1 
ATOM   176  O O   . THR A 1 25  ? -22.25136 19.72474 -39.17670 1.000 30.13678 ? 25  THR A O   1 
ATOM   177  C CB  . THR A 1 25  ? -23.47746 18.19266 -36.87380 1.000 28.49942 ? 25  THR A CB  1 
ATOM   178  O OG1 . THR A 1 25  ? -24.68338 17.59029 -36.37751 1.000 40.60524 ? 25  THR A OG1 1 
ATOM   179  C CG2 . THR A 1 25  ? -22.41394 18.16170 -35.77144 1.000 31.40356 ? 25  THR A CG2 1 
ATOM   180  N N   . THR A 1 26  ? -21.91490 21.20647 -37.51853 1.000 29.06582 ? 26  THR A N   1 
ATOM   181  C CA  . THR A 1 26  ? -20.72468 21.78893 -38.12072 1.000 25.25752 ? 26  THR A CA  1 
ATOM   182  C C   . THR A 1 26  ? -19.58714 21.74279 -37.12581 1.000 29.19323 ? 26  THR A C   1 
ATOM   183  O O   . THR A 1 26  ? -19.76560 22.10414 -35.96251 1.000 32.68395 ? 26  THR A O   1 
ATOM   184  C CB  . THR A 1 26  ? -20.95796 23.23145 -38.55896 1.000 31.19773 ? 26  THR A CB  1 
ATOM   185  O OG1 . THR A 1 26  ? -21.91616 23.25285 -39.61734 1.000 30.72309 ? 26  THR A OG1 1 
ATOM   186  C CG2 . THR A 1 26  ? -19.66798 23.81640 -39.06861 1.000 33.43545 ? 26  THR A CG2 1 
ATOM   187  N N   . LEU A 1 27  ? -18.41623 21.30793 -37.58946 1.000 24.48466 ? 27  LEU A N   1 
ATOM   188  C CA  . LEU A 1 27  ? -17.23756 21.20950 -36.73862 1.000 21.37242 ? 27  LEU A CA  1 
ATOM   189  C C   . LEU A 1 27  ? -16.03803 21.59363 -37.59599 1.000 20.42285 ? 27  LEU A C   1 
ATOM   190  O O   . LEU A 1 27  ? -16.17587 22.00252 -38.75127 1.000 21.16910 ? 27  LEU A O   1 
ATOM   191  C CB  . LEU A 1 27  ? -17.09563 19.80050 -36.15213 1.000 23.68592 ? 27  LEU A CB  1 
ATOM   192  C CG  . LEU A 1 27  ? -18.09659 19.19467 -35.18402 1.000 34.85953 ? 27  LEU A CG  1 
ATOM   193  C CD1 . LEU A 1 27  ? -17.57339 17.80821 -34.86343 1.000 34.12660 ? 27  LEU A CD1 1 
ATOM   194  C CD2 . LEU A 1 27  ? -18.21477 20.05540 -33.92647 1.000 37.31922 ? 27  LEU A CD2 1 
ATOM   195  N N   . ASN A 1 28  ? -14.84667 21.49916 -37.02249 1.000 19.34894 ? 28  ASN A N   1 
ATOM   196  C CA  . ASN A 1 28  ? -13.61957 21.84757 -37.72991 1.000 20.49563 ? 28  ASN A CA  1 
ATOM   197  C C   . ASN A 1 28  ? -12.93384 20.62711 -38.33623 1.000 21.20661 ? 28  ASN A C   1 
ATOM   198  O O   . ASN A 1 28  ? -13.02783 19.51706 -37.81126 1.000 21.57408 ? 28  ASN A O   1 
ATOM   199  C CB  . ASN A 1 28  ? -12.63798 22.51553 -36.75629 1.000 20.71367 ? 28  ASN A CB  1 
ATOM   200  C CG  . ASN A 1 28  ? -13.22901 23.72239 -36.09630 1.000 18.07016 ? 28  ASN A CG  1 
ATOM   201  O OD1 . ASN A 1 28  ? -13.35635 24.78368 -36.72121 1.000 22.23690 ? 28  ASN A OD1 1 
ATOM   202  N ND2 . ASN A 1 28  ? -13.58500 23.58405 -34.79575 1.000 19.49290 ? 28  ASN A ND2 1 
ATOM   203  N N   . GLY A 1 29  ? -12.24449 20.84519 -39.46427 1.000 20.39461 ? 29  GLY A N   1 
ATOM   204  C CA  . GLY A 1 29  ? -11.47383 19.79531 -40.09466 1.000 19.63540 ? 29  GLY A CA  1 
ATOM   205  C C   . GLY A 1 29  ? -10.06908 20.25621 -40.42936 1.000 15.85960 ? 29  GLY A C   1 
ATOM   206  O O   . GLY A 1 29  ? -9.78645  21.44018 -40.56018 1.000 20.29687 ? 29  GLY A O   1 
ATOM   207  N N   . LEU A 1 30  ? -9.19218  19.27596 -40.60549 1.000 19.27672 ? 30  LEU A N   1 
ATOM   208  C CA  . LEU A 1 30  ? -7.78237  19.50448 -40.90310 1.000 20.01981 ? 30  LEU A CA  1 
ATOM   209  C C   . LEU A 1 30  ? -7.51301  18.97612 -42.31072 1.000 22.48917 ? 30  LEU A C   1 
ATOM   210  O O   . LEU A 1 30  ? -7.63468  17.76754 -42.55248 1.000 20.07637 ? 30  LEU A O   1 
ATOM   211  C CB  . LEU A 1 30  ? -6.90394  18.79867 -39.88742 1.000 20.38677 ? 30  LEU A CB  1 
ATOM   212  C CG  . LEU A 1 30  ? -5.39442  19.03759 -40.00620 1.000 17.83492 ? 30  LEU A CG  1 
ATOM   213  C CD1 . LEU A 1 30  ? -5.06898  20.44735 -39.53704 1.000 18.08746 ? 30  LEU A CD1 1 
ATOM   214  C CD2 . LEU A 1 30  ? -4.61136  18.00745 -39.23588 1.000 19.85777 ? 30  LEU A CD2 1 
ATOM   215  N N   . TRP A 1 31  ? -7.18541  19.88435 -43.21714 1.000 18.48964 ? 31  TRP A N   1 
ATOM   216  C CA  . TRP A 1 31  ? -6.99416  19.59928 -44.65283 1.000 18.39173 ? 31  TRP A CA  1 
ATOM   217  C C   . TRP A 1 31  ? -5.49541  19.49136 -44.96086 1.000 21.06449 ? 31  TRP A C   1 
ATOM   218  O O   . TRP A 1 31  ? -4.78694  20.49459 -44.97731 1.000 19.26805 ? 31  TRP A O   1 
ATOM   219  C CB  . TRP A 1 31  ? -7.66424  20.71436 -45.44971 1.000 19.33235 ? 31  TRP A CB  1 
ATOM   220  C CG  . TRP A 1 31  ? -7.65380  20.58908 -46.98470 1.000 22.01942 ? 31  TRP A CG  1 
ATOM   221  C CD1 . TRP A 1 31  ? -7.53485  19.44804 -47.72593 1.000 21.54309 ? 31  TRP A CD1 1 
ATOM   222  C CD2 . TRP A 1 31  ? -7.78579  21.66414 -47.90807 1.000 19.67436 ? 31  TRP A CD2 1 
ATOM   223  N NE1 . TRP A 1 31  ? -7.57949  19.75173 -49.06764 1.000 19.95530 ? 31  TRP A NE1 1 
ATOM   224  C CE2 . TRP A 1 31  ? -7.73227  21.10526 -49.21257 1.000 21.49686 ? 31  TRP A CE2 1 
ATOM   225  C CE3 . TRP A 1 31  ? -7.90298  23.05407 -47.76902 1.000 21.77930 ? 31  TRP A CE3 1 
ATOM   226  C CZ2 . TRP A 1 31  ? -7.82480  21.88798 -50.36338 1.000 23.60596 ? 31  TRP A CZ2 1 
ATOM   227  C CZ3 . TRP A 1 31  ? -7.99889  23.83432 -48.90457 1.000 26.12280 ? 31  TRP A CZ3 1 
ATOM   228  C CH2 . TRP A 1 31  ? -7.95839  23.24757 -50.19827 1.000 21.53044 ? 31  TRP A CH2 1 
ATOM   229  N N   . LEU A 1 32  ? -5.02013  18.27831 -45.23505 1.000 18.54778 ? 32  LEU A N   1 
ATOM   230  C CA  . LEU A 1 32  ? -3.61583  18.01708 -45.54443 1.000 17.28688 ? 32  LEU A CA  1 
ATOM   231  C C   . LEU A 1 32  ? -3.58626  17.26055 -46.86077 1.000 21.73445 ? 32  LEU A C   1 
ATOM   232  O O   . LEU A 1 32  ? -4.19882  16.19819 -46.96702 1.000 20.62124 ? 32  LEU A O   1 
ATOM   233  C CB  . LEU A 1 32  ? -2.96974  17.19310 -44.44057 1.000 21.90379 ? 32  LEU A CB  1 
ATOM   234  C CG  . LEU A 1 32  ? -2.99959  17.76768 -43.02066 1.000 23.14324 ? 32  LEU A CG  1 
ATOM   235  C CD1 . LEU A 1 32  ? -2.41374  16.72813 -42.07074 1.000 20.07737 ? 32  LEU A CD1 1 
ATOM   236  C CD2 . LEU A 1 32  ? -2.20348  19.05492 -42.93219 1.000 24.59884 ? 32  LEU A CD2 1 
ATOM   237  N N   . ASP A 1 33  ? -2.82910  17.77266 -47.83612 1.000 22.05325 ? 33  ASP A N   1 
ATOM   238  C CA  . ASP A 1 33  ? -2.87649  17.22185 -49.21787 1.000 22.78637 ? 33  ASP A CA  1 
ATOM   239  C C   . ASP A 1 33  ? -4.34817  17.12430 -49.61294 1.000 18.44209 ? 33  ASP A C   1 
ATOM   240  O O   . ASP A 1 33  ? -5.05148  18.13756 -49.52846 1.000 23.47572 ? 33  ASP A O   1 
ATOM   241  C CB  . ASP A 1 33  ? -2.09672  15.92940 -49.26320 1.000 23.27702 ? 33  ASP A CB  1 
ATOM   242  C CG  . ASP A 1 33  ? -0.61132  16.15754 -48.96333 1.000 25.52343 ? 33  ASP A CG  1 
ATOM   243  O OD1 . ASP A 1 33  ? -0.10632  17.23232 -49.36057 1.000 29.52169 ? 33  ASP A OD1 1 
ATOM   244  O OD2 . ASP A 1 33  ? 0.02284   15.28756 -48.34354 1.000 31.20315 ? 33  ASP A OD2 1 
ATOM   245  N N   . ASP A 1 34  ? -4.84210  15.96072 -50.04203 1.000 21.16771 ? 34  ASP A N   1 
ATOM   246  C CA  . ASP A 1 34  ? -6.21163  15.88444 -50.54171 1.000 22.42250 ? 34  ASP A CA  1 
ATOM   247  C C   . ASP A 1 34  ? -7.12680  15.17859 -49.55531 1.000 21.39993 ? 34  ASP A C   1 
ATOM   248  O O   . ASP A 1 34  ? -8.10291  14.54950 -49.95010 1.000 23.07184 ? 34  ASP A O   1 
ATOM   249  C CB  . ASP A 1 34  ? -6.26928  15.21248 -51.92508 1.000 24.49205 ? 34  ASP A CB  1 
ATOM   250  C CG  . ASP A 1 34  ? -5.70134  13.78503 -51.91660 1.000 33.05050 ? 34  ASP A CG  1 
ATOM   251  O OD1 . ASP A 1 34  ? -4.97866  13.40698 -50.96881 1.000 30.89455 ? 34  ASP A OD1 1 
ATOM   252  O OD2 . ASP A 1 34  ? -5.94765  13.04429 -52.89947 1.000 32.08480 ? 34  ASP A OD2 1 
ATOM   253  N N   . VAL A 1 35  ? -6.85672  15.30744 -48.24906 1.000 23.06697 ? 35  VAL A N   1 
ATOM   254  C CA  . VAL A 1 35  ? -7.64389  14.61784 -47.23401 1.000 20.07353 ? 35  VAL A CA  1 
ATOM   255  C C   . VAL A 1 35  ? -8.04313  15.60825 -46.15302 1.000 27.12559 ? 35  VAL A C   1 
ATOM   256  O O   . VAL A 1 35  ? -7.21518  16.39153 -45.69719 1.000 21.85477 ? 35  VAL A O   1 
ATOM   257  C CB  . VAL A 1 35  ? -6.89473  13.43864 -46.58766 1.000 21.46811 ? 35  VAL A CB  1 
ATOM   258  C CG1 . VAL A 1 35  ? -7.78185  12.79254 -45.57245 1.000 22.10044 ? 35  VAL A CG1 1 
ATOM   259  C CG2 . VAL A 1 35  ? -6.49748  12.38968 -47.64092 1.000 27.42394 ? 35  VAL A CG2 1 
ATOM   260  N N   . VAL A 1 36  ? -9.29245  15.53469 -45.70467 1.000 20.84861 ? 36  VAL A N   1 
ATOM   261  C CA  . VAL A 1 36  ? -9.77450  16.29688 -44.54976 1.000 21.13085 ? 36  VAL A CA  1 
ATOM   262  C C   . VAL A 1 36  ? -10.01533 15.32073 -43.40251 1.000 21.93530 ? 36  VAL A C   1 
ATOM   263  O O   . VAL A 1 36  ? -10.76940 14.34702 -43.53449 1.000 21.76845 ? 36  VAL A O   1 
ATOM   264  C CB  . VAL A 1 36  ? -11.03491 17.11680 -44.90100 1.000 20.04665 ? 36  VAL A CB  1 
ATOM   265  C CG1 . VAL A 1 36  ? -11.58317 17.84527 -43.65459 1.000 20.50766 ? 36  VAL A CG1 1 
ATOM   266  C CG2 . VAL A 1 36  ? -10.71579 18.18643 -46.01529 1.000 20.26149 ? 36  VAL A CG2 1 
ATOM   267  N N   . TYR A 1 37  ? -9.39114  15.59433 -42.25763 1.000 19.16966 ? 37  TYR A N   1 
ATOM   268  C CA  . TYR A 1 37  ? -9.54580  14.78086 -41.06089 1.000 17.29546 ? 37  TYR A CA  1 
ATOM   269  C C   . TYR A 1 37  ? -10.44190 15.55437 -40.08876 1.000 20.83510 ? 37  TYR A C   1 
ATOM   270  O O   . TYR A 1 37  ? -10.22286 16.75079 -39.86930 1.000 22.20241 ? 37  TYR A O   1 
ATOM   271  C CB  . TYR A 1 37  ? -8.18561  14.49297 -40.39159 1.000 21.08808 ? 37  TYR A CB  1 
ATOM   272  C CG  . TYR A 1 37  ? -7.13638  13.89775 -41.31700 1.000 19.73472 ? 37  TYR A CG  1 
ATOM   273  C CD1 . TYR A 1 37  ? -6.49825  14.68074 -42.25674 1.000 22.73501 ? 37  TYR A CD1 1 
ATOM   274  C CD2 . TYR A 1 37  ? -6.83235  12.53795 -41.25974 1.000 23.15222 ? 37  TYR A CD2 1 
ATOM   275  C CE1 . TYR A 1 37  ? -5.55816  14.12816 -43.13861 1.000 24.89096 ? 37  TYR A CE1 1 
ATOM   276  C CE2 . TYR A 1 37  ? -5.89858  11.98395 -42.11961 1.000 23.62043 ? 37  TYR A CE2 1 
ATOM   277  C CZ  . TYR A 1 37  ? -5.27106  12.78154 -43.04661 1.000 29.54359 ? 37  TYR A CZ  1 
ATOM   278  O OH  . TYR A 1 37  ? -4.36565  12.22728 -43.92299 1.000 29.51745 ? 37  TYR A OH  1 
ATOM   279  N N   . CYS A 1 38  ? -11.45353 14.90464 -39.53089 1.000 23.98273 ? 38  CYS A N   1 
ATOM   280  C CA  . CYS A 1 38  ? -12.30805 15.60724 -38.57744 1.000 24.86166 ? 38  CYS A CA  1 
ATOM   281  C C   . CYS A 1 38  ? -12.91158 14.59688 -37.62481 1.000 24.61234 ? 38  CYS A C   1 
ATOM   282  O O   . CYS A 1 38  ? -12.77780 13.38007 -37.82055 1.000 23.67207 ? 38  CYS A O   1 
ATOM   283  C CB  . CYS A 1 38  ? -13.40079 16.42295 -39.28626 1.000 24.93500 ? 38  CYS A CB  1 
ATOM   284  S SG  . CYS A 1 38  ? -14.78279 15.42478 -40.03372 1.000 28.47017 ? 38  CYS A SG  1 
ATOM   285  N N   . PRO A 1 39  ? -13.51664 15.05521 -36.52655 1.000 20.25107 ? 39  PRO A N   1 
ATOM   286  C CA  . PRO A 1 39  ? -14.10888 14.11628 -35.57691 1.000 20.41747 ? 39  PRO A CA  1 
ATOM   287  C C   . PRO A 1 39  ? -15.32890 13.45038 -36.17888 1.000 18.95909 ? 39  PRO A C   1 
ATOM   288  O O   . PRO A 1 39  ? -16.12992 14.08739 -36.85683 1.000 24.13391 ? 39  PRO A O   1 
ATOM   289  C CB  . PRO A 1 39  ? -14.49554 15.00036 -34.37983 1.000 26.63776 ? 39  PRO A CB  1 
ATOM   290  C CG  . PRO A 1 39  ? -13.67725 16.22306 -34.54340 1.000 26.27920 ? 39  PRO A CG  1 
ATOM   291  C CD  . PRO A 1 39  ? -13.55689 16.43738 -36.01379 1.000 24.86347 ? 39  PRO A CD  1 
ATOM   292  N N   . ARG A 1 40  ? -15.47701 12.16230 -35.88478 1.000 23.88287 ? 40  ARG A N   1 
ATOM   293  C CA  . ARG A 1 40  ? -16.57835 11.43482 -36.48531 1.000 23.85499 ? 40  ARG A CA  1 
ATOM   294  C C   . ARG A 1 40  ? -17.93091 11.93159 -35.99665 1.000 27.58568 ? 40  ARG A C   1 
ATOM   295  O O   . ARG A 1 40  ? -18.91873 11.77281 -36.71563 1.000 22.36967 ? 40  ARG A O   1 
ATOM   296  C CB  . ARG A 1 40  ? -16.42665 9.92535  -36.25380 1.000 26.59356 ? 40  ARG A CB  1 
ATOM   297  C CG  . ARG A 1 40  ? -16.40680 9.44999  -34.78972 1.000 24.43481 ? 40  ARG A CG  1 
ATOM   298  C CD  . ARG A 1 40  ? -16.29332 7.92340  -34.77582 1.000 24.22451 ? 40  ARG A CD  1 
ATOM   299  N NE  . ARG A 1 40  ? -16.10776 7.37973  -33.43743 1.000 23.02559 ? 40  ARG A NE  1 
ATOM   300  C CZ  . ARG A 1 40  ? -16.18428 6.08504  -33.16003 1.000 28.61791 ? 40  ARG A CZ  1 
ATOM   301  N NH1 . ARG A 1 40  ? -16.25885 5.17849  -34.12687 1.000 28.73362 ? 40  ARG A NH1 1 
ATOM   302  N NH2 . ARG A 1 40  ? -16.17382 5.68720  -31.89156 1.000 26.59418 ? 40  ARG A NH2 1 
ATOM   303  N N   . HIS A 1 41  ? -18.02232 12.55842 -34.82377 1.000 22.26328 ? 41  HIS A N   1 
ATOM   304  C CA  . HIS A 1 41  ? -19.37674 12.89059 -34.40477 1.000 26.47222 ? 41  HIS A CA  1 
ATOM   305  C C   . HIS A 1 41  ? -19.96215 14.07941 -35.16575 1.000 30.36993 ? 41  HIS A C   1 
ATOM   306  O O   . HIS A 1 41  ? -21.06622 14.51266 -34.83228 1.000 26.96652 ? 41  HIS A O   1 
ATOM   307  C CB  . HIS A 1 41  ? -19.46535 13.06686 -32.87696 1.000 28.25296 ? 41  HIS A CB  1 
ATOM   308  C CG  . HIS A 1 41  ? -18.80669 14.29245 -32.31941 1.000 23.79948 ? 41  HIS A CG  1 
ATOM   309  N ND1 . HIS A 1 41  ? -17.60873 14.23562 -31.64350 1.000 27.56977 ? 41  HIS A ND1 1 
ATOM   310  C CD2 . HIS A 1 41  ? -19.22260 15.57836 -32.23659 1.000 24.47797 ? 41  HIS A CD2 1 
ATOM   311  C CE1 . HIS A 1 41  ? -17.28620 15.44546 -31.21391 1.000 30.85089 ? 41  HIS A CE1 1 
ATOM   312  N NE2 . HIS A 1 41  ? -18.25302 16.27884 -31.55371 1.000 32.01418 ? 41  HIS A NE2 1 
ATOM   313  N N   . VAL A 1 42  ? -19.29961 14.56550 -36.22499 1.000 22.14799 ? 42  VAL A N   1 
ATOM   314  C CA  . VAL A 1 42  ? -19.96194 15.45589 -37.17768 1.000 18.31828 ? 42  VAL A CA  1 
ATOM   315  C C   . VAL A 1 42  ? -21.18807 14.78095 -37.81511 1.000 21.98350 ? 42  VAL A C   1 
ATOM   316  O O   . VAL A 1 42  ? -22.09587 15.46716 -38.31369 1.000 28.69239 ? 42  VAL A O   1 
ATOM   317  C CB  . VAL A 1 42  ? -18.94041 15.93750 -38.25062 1.000 24.44105 ? 42  VAL A CB  1 
ATOM   318  C CG1 . VAL A 1 42  ? -18.68330 14.86280 -39.28935 1.000 21.91393 ? 42  VAL A CG1 1 
ATOM   319  C CG2 . VAL A 1 42  ? -19.38048 17.23714 -38.89910 1.000 25.45536 ? 42  VAL A CG2 1 
ATOM   320  N N   . ILE A 1 43  ? -21.26518 13.44698 -37.78893 1.000 27.26991 ? 43  ILE A N   1 
ATOM   321  C CA  . ILE A 1 43  ? -22.38440 12.78804 -38.45965 1.000 24.85467 ? 43  ILE A CA  1 
ATOM   322  C C   . ILE A 1 43  ? -23.52226 12.53684 -37.47628 1.000 31.81056 ? 43  ILE A C   1 
ATOM   323  O O   . ILE A 1 43  ? -24.52468 11.90832 -37.82846 1.000 31.89113 ? 43  ILE A O   1 
ATOM   324  C CB  . ILE A 1 43  ? -21.96340 11.47031 -39.13557 1.000 23.10120 ? 43  ILE A CB  1 
ATOM   325  C CG1 . ILE A 1 43  ? -21.51972 10.41988 -38.13379 1.000 30.73502 ? 43  ILE A CG1 1 
ATOM   326  C CG2 . ILE A 1 43  ? -20.84586 11.70835 -40.12694 1.000 30.27689 ? 43  ILE A CG2 1 
ATOM   327  C CD1 . ILE A 1 43  ? -21.12781 9.13349  -38.86931 1.000 26.41744 ? 43  ILE A CD1 1 
ATOM   328  N N   . CYS A 1 44  ? -23.40166 13.03769 -36.25860 1.000 26.76357 ? 44  CYS A N   1 
ATOM   329  C CA  . CYS A 1 44  ? -24.41075 12.77824 -35.23490 1.000 27.24970 ? 44  CYS A CA  1 
ATOM   330  C C   . CYS A 1 44  ? -25.40598 13.91771 -35.18167 1.000 29.47514 ? 44  CYS A C   1 
ATOM   331  O O   . CYS A 1 44  ? -25.03526 15.08692 -35.33052 1.000 34.35794 ? 44  CYS A O   1 
ATOM   332  C CB  . CYS A 1 44  ? -23.78961 12.61529 -33.85228 1.000 31.92523 ? 44  CYS A CB  1 
ATOM   333  S SG  . CYS A 1 44  ? -22.86904 11.12636 -33.63416 1.000 38.08281 ? 44  CYS A SG  1 
ATOM   334  N N   . THR A 1 45  ? -26.67466 13.57953 -34.97132 1.000 33.56755 ? 45  THR A N   1 
ATOM   335  C CA  . THR A 1 45  ? -27.56998 14.61121 -34.48593 1.000 41.17337 ? 45  THR A CA  1 
ATOM   336  C C   . THR A 1 45  ? -27.45078 14.69181 -32.96813 1.000 41.79024 ? 45  THR A C   1 
ATOM   337  O O   . THR A 1 45  ? -26.86470 13.81982 -32.31837 1.000 44.41157 ? 45  THR A O   1 
ATOM   338  C CB  . THR A 1 45  ? -29.01321 14.32451 -34.89782 1.000 43.27641 ? 45  THR A CB  1 
ATOM   339  O OG1 . THR A 1 45  ? -29.45100 13.12420 -34.25492 1.000 42.69731 ? 45  THR A OG1 1 
ATOM   340  C CG2 . THR A 1 45  ? -29.10223 14.14689 -36.41741 1.000 34.50246 ? 45  THR A CG2 1 
ATOM   341  N N   . SER A 1 46  ? -28.02885 15.74889 -32.39650 1.000 41.89995 ? 46  SER A N   1 
ATOM   342  C CA  . SER A 1 46  ? -28.01258 15.89402 -30.94351 1.000 52.75585 ? 46  SER A CA  1 
ATOM   343  C C   . SER A 1 46  ? -28.54546 14.63876 -30.25000 1.000 55.84929 ? 46  SER A C   1 
ATOM   344  O O   . SER A 1 46  ? -27.94814 14.15692 -29.27842 1.000 49.67373 ? 46  SER A O   1 
ATOM   345  C CB  . SER A 1 46  ? -28.80765 17.13891 -30.54201 1.000 57.51034 ? 46  SER A CB  1 
ATOM   346  O OG  . SER A 1 46  ? -29.91576 17.33649 -31.40547 1.000 65.32252 ? 46  SER A OG  1 
ATOM   347  N N   . GLU A 1 47  ? -29.64631 14.06925 -30.75931 1.000 50.60193 ? 47  GLU A N   1 
ATOM   348  C CA  . GLU A 1 47  ? -30.18791 12.83881 -30.18657 1.000 42.19692 ? 47  GLU A CA  1 
ATOM   349  C C   . GLU A 1 47  ? -29.25906 11.63466 -30.36181 1.000 39.60482 ? 47  GLU A C   1 
ATOM   350  O O   . GLU A 1 47  ? -29.28431 10.72532 -29.52646 1.000 44.29398 ? 47  GLU A O   1 
ATOM   351  C CB  . GLU A 1 47  ? -31.56061 12.53551 -30.80018 1.000 49.29617 ? 47  GLU A CB  1 
ATOM   352  N N   . ASP A 1 48  ? -28.43353 11.59730 -31.41206 1.000 37.61847 ? 48  ASP A N   1 
ATOM   353  C CA  . ASP A 1 48  ? -27.55243 10.44790 -31.60499 1.000 36.70691 ? 48  ASP A CA  1 
ATOM   354  C C   . ASP A 1 48  ? -26.41301 10.37284 -30.60277 1.000 42.01162 ? 48  ASP A C   1 
ATOM   355  O O   . ASP A 1 48  ? -25.80778 9.30664  -30.45457 1.000 33.32769 ? 48  ASP A O   1 
ATOM   356  C CB  . ASP A 1 48  ? -26.91862 10.45560 -32.99798 1.000 27.71763 ? 48  ASP A CB  1 
ATOM   357  C CG  . ASP A 1 48  ? -27.92682 10.20832 -34.09633 1.000 45.87489 ? 48  ASP A CG  1 
ATOM   358  O OD1 . ASP A 1 48  ? -28.72696 9.25006  -33.97923 1.000 48.32685 ? 48  ASP A OD1 1 
ATOM   359  O OD2 . ASP A 1 48  ? -27.92217 10.99091 -35.06895 1.000 43.42390 ? 48  ASP A OD2 1 
ATOM   360  N N   . MET A 1 49  ? -26.09912 11.45684 -29.91268 1.000 44.34799 ? 49  MET A N   1 
ATOM   361  C CA  . MET A 1 49  ? -24.79570 11.49535 -29.26651 1.000 37.68542 ? 49  MET A CA  1 
ATOM   362  C C   . MET A 1 49  ? -24.73531 10.75911 -27.93186 1.000 31.10082 ? 49  MET A C   1 
ATOM   363  O O   . MET A 1 49  ? -23.63849 10.53096 -27.42621 1.000 35.57264 ? 49  MET A O   1 
ATOM   364  C CB  . MET A 1 49  ? -24.35612 12.94830 -29.13433 1.000 45.18928 ? 49  MET A CB  1 
ATOM   365  C CG  . MET A 1 49  ? -23.82613 13.42420 -30.47115 1.000 43.93599 ? 49  MET A CG  1 
ATOM   366  S SD  . MET A 1 49  ? -23.48308 15.15751 -30.46615 1.000 47.03880 ? 49  MET A SD  1 
ATOM   367  C CE  . MET A 1 49  ? -24.78058 15.69835 -29.35092 1.000 61.99569 ? 49  MET A CE  1 
ATOM   368  N N   . PHE A 1 50  ? -25.85455 10.30624 -27.38691 1.000 30.74123 ? 50  PHE A N   1 
ATOM   369  C CA  . PHE A 1 50  ? -25.79039 9.56240  -26.13104 1.000 27.48215 ? 50  PHE A CA  1 
ATOM   370  C C   . PHE A 1 50  ? -25.30246 8.12714  -26.29826 1.000 33.34324 ? 50  PHE A C   1 
ATOM   371  O O   . PHE A 1 50  ? -24.61345 7.61267  -25.41246 1.000 35.79185 ? 50  PHE A O   1 
ATOM   372  C CB  . PHE A 1 50  ? -27.16295 9.60758  -25.47441 1.000 28.62525 ? 50  PHE A CB  1 
ATOM   373  C CG  . PHE A 1 50  ? -27.57949 11.00495 -25.15215 1.000 36.58096 ? 50  PHE A CG  1 
ATOM   374  C CD1 . PHE A 1 50  ? -27.13764 11.60913 -23.97729 1.000 35.91283 ? 50  PHE A CD1 1 
ATOM   375  C CD2 . PHE A 1 50  ? -28.32341 11.74880 -26.05231 1.000 39.08553 ? 50  PHE A CD2 1 
ATOM   376  C CE1 . PHE A 1 50  ? -27.48403 12.91557 -23.67936 1.000 31.47419 ? 50  PHE A CE1 1 
ATOM   377  C CE2 . PHE A 1 50  ? -28.67688 13.05293 -25.76521 1.000 38.38318 ? 50  PHE A CE2 1 
ATOM   378  C CZ  . PHE A 1 50  ? -28.25231 13.64134 -24.57939 1.000 36.66104 ? 50  PHE A CZ  1 
ATOM   379  N N   . ASN A 1 51  ? -25.63420 7.46175  -27.41431 1.000 35.01373 ? 51  ASN A N   1 
ATOM   380  C CA  . ASN A 1 51  ? -25.16164 6.10037  -27.68428 1.000 31.93848 ? 51  ASN A CA  1 
ATOM   381  C C   . ASN A 1 51  ? -25.07257 5.92196  -29.19355 1.000 35.15006 ? 51  ASN A C   1 
ATOM   382  O O   . ASN A 1 51  ? -25.80471 5.13098  -29.79143 1.000 34.92959 ? 51  ASN A O   1 
ATOM   383  C CB  . ASN A 1 51  ? -26.09139 5.06085  -27.05838 1.000 38.50807 ? 51  ASN A CB  1 
ATOM   384  N N   . PRO A 1 52  ? -24.18052 6.65742  -29.84730 1.000 29.50009 ? 52  PRO A N   1 
ATOM   385  C CA  . PRO A 1 52  ? -24.15499 6.64220  -31.31921 1.000 26.53402 ? 52  PRO A CA  1 
ATOM   386  C C   . PRO A 1 52  ? -23.61046 5.33036  -31.86500 1.000 26.48009 ? 52  PRO A C   1 
ATOM   387  O O   . PRO A 1 52  ? -22.68256 4.73761  -31.31330 1.000 33.23541 ? 52  PRO A O   1 
ATOM   388  C CB  . PRO A 1 52  ? -23.22959 7.81683  -31.66848 1.000 35.43171 ? 52  PRO A CB  1 
ATOM   389  C CG  . PRO A 1 52  ? -22.31195 7.92798  -30.47607 1.000 34.55459 ? 52  PRO A CG  1 
ATOM   390  C CD  . PRO A 1 52  ? -23.13052 7.51361  -29.25888 1.000 26.57897 ? 52  PRO A CD  1 
ATOM   391  N N   . ASN A 1 53  ? -24.19588 4.86492  -32.96822 1.000 28.24536 ? 53  ASN A N   1 
ATOM   392  C CA  . ASN A 1 53  ? -23.56616 3.80389  -33.75191 1.000 31.30274 ? 53  ASN A CA  1 
ATOM   393  C C   . ASN A 1 53  ? -22.97269 4.47878  -34.98463 1.000 29.15808 ? 53  ASN A C   1 
ATOM   394  O O   . ASN A 1 53  ? -23.67249 4.77038  -35.95352 1.000 28.33084 ? 53  ASN A O   1 
ATOM   395  C CB  . ASN A 1 53  ? -24.55349 2.70246  -34.11846 1.000 32.45598 ? 53  ASN A CB  1 
ATOM   396  C CG  . ASN A 1 53  ? -23.87088 1.54843  -34.79564 1.000 31.85449 ? 53  ASN A CG  1 
ATOM   397  O OD1 . ASN A 1 53  ? -22.84725 1.73096  -35.46908 1.000 29.08818 ? 53  ASN A OD1 1 
ATOM   398  N ND2 . ASN A 1 53  ? -24.40100 0.34859  -34.61032 1.000 31.06396 ? 53  ASN A ND2 1 
ATOM   399  N N   . TYR A 1 54  ? -21.66478 4.76257  -34.92078 1.000 27.50407 ? 54  TYR A N   1 
ATOM   400  C CA  . TYR A 1 54  ? -21.05697 5.61874  -35.92592 1.000 30.97095 ? 54  TYR A CA  1 
ATOM   401  C C   . TYR A 1 54  ? -20.98491 4.90993  -37.27095 1.000 24.33053 ? 54  TYR A C   1 
ATOM   402  O O   . TYR A 1 54  ? -21.22447 5.51989  -38.31956 1.000 27.46561 ? 54  TYR A O   1 
ATOM   403  C CB  . TYR A 1 54  ? -19.65746 6.03889  -35.46385 1.000 27.51390 ? 54  TYR A CB  1 
ATOM   404  C CG  . TYR A 1 54  ? -19.67947 7.10889  -34.38422 1.000 23.12704 ? 54  TYR A CG  1 
ATOM   405  C CD1 . TYR A 1 54  ? -20.03691 8.41998  -34.70138 1.000 26.52922 ? 54  TYR A CD1 1 
ATOM   406  C CD2 . TYR A 1 54  ? -19.32750 6.81222  -33.06880 1.000 31.19997 ? 54  TYR A CD2 1 
ATOM   407  C CE1 . TYR A 1 54  ? -20.05605 9.42389  -33.72130 1.000 26.84087 ? 54  TYR A CE1 1 
ATOM   408  C CE2 . TYR A 1 54  ? -19.33853 7.81406  -32.06071 1.000 20.84094 ? 54  TYR A CE2 1 
ATOM   409  C CZ  . TYR A 1 54  ? -19.70304 9.11036  -32.40932 1.000 25.98143 ? 54  TYR A CZ  1 
ATOM   410  O OH  . TYR A 1 54  ? -19.71062 10.10956 -31.45204 1.000 28.44537 ? 54  TYR A OH  1 
ATOM   411  N N   . GLU A 1 55  ? -20.63697 3.62416  -37.24487 1.000 30.36079 ? 55  GLU A N   1 
ATOM   412  C CA  . GLU A 1 55  ? -20.64003 2.82056  -38.46151 1.000 31.22419 ? 55  GLU A CA  1 
ATOM   413  C C   . GLU A 1 55  ? -22.00186 2.86072  -39.12779 1.000 34.47469 ? 55  GLU A C   1 
ATOM   414  O O   . GLU A 1 55  ? -22.10233 3.03457  -40.34589 1.000 31.86289 ? 55  GLU A O   1 
ATOM   415  C CB  . GLU A 1 55  ? -20.25609 1.37672  -38.13667 1.000 30.30511 ? 55  GLU A CB  1 
ATOM   416  C CG  . GLU A 1 55  ? -18.80397 1.16970  -37.69157 1.000 38.71064 ? 55  GLU A CG  1 
ATOM   417  C CD  . GLU A 1 55  ? -18.55744 1.38745  -36.19743 1.000 37.20308 ? 55  GLU A CD  1 
ATOM   418  O OE1 . GLU A 1 55  ? -19.46921 1.84636  -35.46287 1.000 36.89639 ? 55  GLU A OE1 1 
ATOM   419  O OE2 . GLU A 1 55  ? -17.42447 1.08347  -35.76215 1.000 42.15885 ? 55  GLU A OE2 1 
ATOM   420  N N   . ASP A 1 56  ? -23.06427 2.68844  -38.34189 1.000 29.75012 ? 56  ASP A N   1 
ATOM   421  C CA  . ASP A 1 56  ? -24.39997 2.75557  -38.91138 1.000 28.34555 ? 56  ASP A CA  1 
ATOM   422  C C   . ASP A 1 56  ? -24.72054 4.14722  -39.44053 1.000 34.54126 ? 56  ASP A C   1 
ATOM   423  O O   . ASP A 1 56  ? -25.31618 4.27516  -40.51275 1.000 35.05439 ? 56  ASP A O   1 
ATOM   424  C CB  . ASP A 1 56  ? -25.43136 2.32241  -37.87339 1.000 32.45529 ? 56  ASP A CB  1 
ATOM   425  C CG  . ASP A 1 56  ? -26.83561 2.42968  -38.39574 1.000 42.78769 ? 56  ASP A CG  1 
ATOM   426  O OD1 . ASP A 1 56  ? -27.12064 1.76518  -39.40943 1.000 37.21180 ? 56  ASP A OD1 1 
ATOM   427  O OD2 . ASP A 1 56  ? -27.64352 3.18091  -37.81101 1.000 42.26005 ? 56  ASP A OD2 1 
ATOM   428  N N   . LEU A 1 57  ? -24.35462 5.20575  -38.69958 1.000 31.36235 ? 57  LEU A N   1 
ATOM   429  C CA  . LEU A 1 57  ? -24.65279 6.56256  -39.15667 1.000 24.60925 ? 57  LEU A CA  1 
ATOM   430  C C   . LEU A 1 57  ? -23.90774 6.88521  -40.44665 1.000 27.22740 ? 57  LEU A C   1 
ATOM   431  O O   . LEU A 1 57  ? -24.42555 7.60715  -41.31166 1.000 35.47220 ? 57  LEU A O   1 
ATOM   432  C CB  . LEU A 1 57  ? -24.28041 7.58581  -38.07694 1.000 30.03027 ? 57  LEU A CB  1 
ATOM   433  C CG  . LEU A 1 57  ? -25.07089 7.55021  -36.76839 1.000 34.10739 ? 57  LEU A CG  1 
ATOM   434  C CD1 . LEU A 1 57  ? -24.46236 8.46236  -35.69732 1.000 32.67574 ? 57  LEU A CD1 1 
ATOM   435  C CD2 . LEU A 1 57  ? -26.47868 7.96796  -37.05448 1.000 34.84463 ? 57  LEU A CD2 1 
ATOM   436  N N   . LEU A 1 58  ? -22.69850 6.35067  -40.59094 1.000 26.10339 ? 58  LEU A N   1 
ATOM   437  C CA  . LEU A 1 58  ? -21.86152 6.62794  -41.75283 1.000 25.36598 ? 58  LEU A CA  1 
ATOM   438  C C   . LEU A 1 58  ? -22.34197 5.87460  -42.99780 1.000 31.51869 ? 58  LEU A C   1 
ATOM   439  O O   . LEU A 1 58  ? -22.24958 6.40693  -44.11165 1.000 28.55927 ? 58  LEU A O   1 
ATOM   440  C CB  . LEU A 1 58  ? -20.40447 6.28436  -41.41969 1.000 22.80643 ? 58  LEU A CB  1 
ATOM   441  C CG  . LEU A 1 58  ? -19.36360 6.73055  -42.45518 1.000 30.05007 ? 58  LEU A CG  1 
ATOM   442  C CD1 . LEU A 1 58  ? -19.51885 8.22324  -42.73660 1.000 34.00217 ? 58  LEU A CD1 1 
ATOM   443  C CD2 . LEU A 1 58  ? -17.95919 6.41419  -41.98628 1.000 34.32369 ? 58  LEU A CD2 1 
ATOM   444  N N   . ILE A 1 59  ? -22.86475 4.65357  -42.82187 1.000 34.38707 ? 59  ILE A N   1 
ATOM   445  C CA  . ILE A 1 59  ? -23.45228 3.88871  -43.93601 1.000 32.76251 ? 59  ILE A CA  1 
ATOM   446  C C   . ILE A 1 59  ? -24.48705 4.71682  -44.68809 1.000 42.95250 ? 59  ILE A C   1 
ATOM   447  O O   . ILE A 1 59  ? -24.62312 4.61661  -45.91686 1.000 35.19936 ? 59  ILE A O   1 
ATOM   448  C CB  . ILE A 1 59  ? -24.10962 2.60470  -43.41070 1.000 39.58721 ? 59  ILE A CB  1 
ATOM   449  C CG1 . ILE A 1 59  ? -23.12245 1.68149  -42.72453 1.000 44.93127 ? 59  ILE A CG1 1 
ATOM   450  C CG2 . ILE A 1 59  ? -24.83686 1.87971  -44.51763 1.000 48.32841 ? 59  ILE A CG2 1 
ATOM   451  C CD1 . ILE A 1 59  ? -23.87451 0.69627  -41.83618 1.000 49.58772 ? 59  ILE A CD1 1 
ATOM   452  N N   . ARG A 1 60  ? -25.28940 5.48459  -43.95378 1.000 36.43318 ? 60  ARG A N   1 
ATOM   453  C CA  . ARG A 1 60  ? -26.36084 6.25797  -44.56783 1.000 37.09242 ? 60  ARG A CA  1 
ATOM   454  C C   . ARG A 1 60  ? -25.87036 7.52345  -45.25322 1.000 39.99616 ? 60  ARG A C   1 
ATOM   455  O O   . ARG A 1 60  ? -26.67963 8.24429  -45.84829 1.000 41.09601 ? 60  ARG A O   1 
ATOM   456  C CB  . ARG A 1 60  ? -27.41167 6.60935  -43.50632 1.000 45.38005 ? 60  ARG A CB  1 
ATOM   457  N N   . LYS A 1 61  ? -24.57653 7.82388  -45.19602 1.000 32.12458 ? 61  LYS A N   1 
ATOM   458  C CA  . LYS A 1 61  ? -24.04310 9.05967  -45.74770 1.000 27.96599 ? 61  LYS A CA  1 
ATOM   459  C C   . LYS A 1 61  ? -23.29258 8.77252  -47.04482 1.000 30.53353 ? 61  LYS A C   1 
ATOM   460  O O   . LYS A 1 61  ? -22.63860 7.73570  -47.17757 1.000 35.30585 ? 61  LYS A O   1 
ATOM   461  C CB  . LYS A 1 61  ? -23.10550 9.74040  -44.73824 1.000 28.93142 ? 61  LYS A CB  1 
ATOM   462  C CG  . LYS A 1 61  ? -23.74203 10.07775 -43.38067 1.000 36.71058 ? 61  LYS A CG  1 
ATOM   463  C CD  . LYS A 1 61  ? -24.81161 11.13754 -43.51094 1.000 37.68342 ? 61  LYS A CD  1 
ATOM   464  C CE  . LYS A 1 61  ? -25.35889 11.54653 -42.13626 1.000 38.59176 ? 61  LYS A CE  1 
ATOM   465  N NZ  . LYS A 1 61  ? -26.02424 10.39840 -41.45112 1.000 50.49240 ? 61  LYS A NZ  1 
ATOM   466  N N   . SER A 1 62  ? -23.43544 9.67620  -48.00527 1.000 31.63258 ? 62  SER A N   1 
ATOM   467  C CA  . SER A 1 62  ? -22.70563 9.68527  -49.26551 1.000 36.64723 ? 62  SER A CA  1 
ATOM   468  C C   . SER A 1 62  ? -21.69573 10.81667 -49.23171 1.000 30.88907 ? 62  SER A C   1 
ATOM   469  O O   . SER A 1 62  ? -21.76194 11.69672 -48.37323 1.000 30.03866 ? 62  SER A O   1 
ATOM   470  C CB  . SER A 1 62  ? -23.66464 9.87915  -50.44490 1.000 27.30203 ? 62  SER A CB  1 
ATOM   471  O OG  . SER A 1 62  ? -24.54486 8.77996  -50.55097 1.000 52.65182 ? 62  SER A OG  1 
ATOM   472  N N   . ASN A 1 63  ? -20.76894 10.81070 -50.19269 1.000 32.42240 ? 63  ASN A N   1 
ATOM   473  C CA  . ASN A 1 63  ? -19.78747 11.89078 -50.23947 1.000 32.22373 ? 63  ASN A CA  1 
ATOM   474  C C   . ASN A 1 63  ? -20.46553 13.25934 -50.17208 1.000 34.27752 ? 63  ASN A C   1 
ATOM   475  O O   . ASN A 1 63  ? -20.02489 14.14233 -49.42908 1.000 25.68647 ? 63  ASN A O   1 
ATOM   476  C CB  . ASN A 1 63  ? -18.90877 11.78006 -51.49329 1.000 27.78205 ? 63  ASN A CB  1 
ATOM   477  C CG  . ASN A 1 63  ? -17.96465 10.57948 -51.46528 1.000 26.52481 ? 63  ASN A CG  1 
ATOM   478  O OD1 . ASN A 1 63  ? -17.48774 10.14718 -50.42921 1.000 27.93361 ? 63  ASN A OD1 1 
ATOM   479  N ND2 . ASN A 1 63  ? -17.67648 10.03497 -52.65797 1.000 28.35369 ? 63  ASN A ND2 1 
ATOM   480  N N   . HIS A 1 64  ? -21.58063 13.44385 -50.88947 1.000 26.99566 ? 64  HIS A N   1 
ATOM   481  C CA  . HIS A 1 64  ? -22.13593 14.78272 -51.05552 1.000 26.82626 ? 64  HIS A CA  1 
ATOM   482  C C   . HIS A 1 64  ? -22.87340 15.28514 -49.81715 1.000 26.70944 ? 64  HIS A C   1 
ATOM   483  O O   . HIS A 1 64  ? -23.23002 16.46354 -49.77180 1.000 30.56104 ? 64  HIS A O   1 
ATOM   484  C CB  . HIS A 1 64  ? -23.06125 14.78942 -52.29116 1.000 28.78537 ? 64  HIS A CB  1 
ATOM   485  C CG  . HIS A 1 64  ? -23.48584 16.15546 -52.74086 1.000 29.79467 ? 64  HIS A CG  1 
ATOM   486  N ND1 . HIS A 1 64  ? -22.71505 16.94649 -53.56562 1.000 32.10691 ? 64  HIS A ND1 1 
ATOM   487  C CD2 . HIS A 1 64  ? -24.61313 16.86478 -52.48677 1.000 28.91020 ? 64  HIS A CD2 1 
ATOM   488  C CE1 . HIS A 1 64  ? -23.34795 18.08129 -53.80884 1.000 28.90599 ? 64  HIS A CE1 1 
ATOM   489  N NE2 . HIS A 1 64  ? -24.49666 18.06335 -53.15265 1.000 31.26105 ? 64  HIS A NE2 1 
ATOM   490  N N   . ASN A 1 65  ? -23.10725 14.42028 -48.83055 1.000 25.26580 ? 65  ASN A N   1 
ATOM   491  C CA  . ASN A 1 65  ? -23.66279 14.78504 -47.52730 1.000 27.67833 ? 65  ASN A CA  1 
ATOM   492  C C   . ASN A 1 65  ? -22.67862 15.57809 -46.67024 1.000 33.51907 ? 65  ASN A C   1 
ATOM   493  O O   . ASN A 1 65  ? -23.08479 16.11363 -45.63250 1.000 28.68986 ? 65  ASN A O   1 
ATOM   494  C CB  . ASN A 1 65  ? -24.08498 13.51392 -46.79056 1.000 25.81331 ? 65  ASN A CB  1 
ATOM   495  C CG  . ASN A 1 65  ? -25.17712 12.72423 -47.53821 1.000 36.12703 ? 65  ASN A CG  1 
ATOM   496  O OD1 . ASN A 1 65  ? -25.25504 11.49578 -47.44942 1.000 38.05841 ? 65  ASN A OD1 1 
ATOM   497  N ND2 . ASN A 1 65  ? -26.00546 13.43175 -48.27849 1.000 49.17627 ? 65  ASN A ND2 1 
ATOM   498  N N   . PHE A 1 66  ? -21.40953 15.65262 -47.07268 1.000 30.63457 ? 66  PHE A N   1 
ATOM   499  C CA  . PHE A 1 66  ? -20.36382 16.36052 -46.33299 1.000 24.42022 ? 66  PHE A CA  1 
ATOM   500  C C   . PHE A 1 66  ? -20.03217 17.63989 -47.08359 1.000 29.02069 ? 66  PHE A C   1 
ATOM   501  O O   . PHE A 1 66  ? -19.52807 17.59706 -48.21591 1.000 27.60110 ? 66  PHE A O   1 
ATOM   502  C CB  . PHE A 1 66  ? -19.10499 15.50148 -46.17145 1.000 24.71785 ? 66  PHE A CB  1 
ATOM   503  C CG  . PHE A 1 66  ? -19.31373 14.28133 -45.34481 1.000 22.07939 ? 66  PHE A CG  1 
ATOM   504  C CD1 . PHE A 1 66  ? -19.27483 14.34602 -43.96942 1.000 29.66001 ? 66  PHE A CD1 1 
ATOM   505  C CD2 . PHE A 1 66  ? -19.52181 13.05634 -45.94665 1.000 28.42664 ? 66  PHE A CD2 1 
ATOM   506  C CE1 . PHE A 1 66  ? -19.46349 13.19792 -43.19477 1.000 27.98359 ? 66  PHE A CE1 1 
ATOM   507  C CE2 . PHE A 1 66  ? -19.72429 11.91942 -45.20038 1.000 39.60166 ? 66  PHE A CE2 1 
ATOM   508  C CZ  . PHE A 1 66  ? -19.70484 11.98369 -43.81049 1.000 33.35519 ? 66  PHE A CZ  1 
ATOM   509  N N   . LEU A 1 67  ? -20.32815 18.76641 -46.46229 1.000 26.86632 ? 67  LEU A N   1 
ATOM   510  C CA  . LEU A 1 67  ? -20.05653 20.08136 -47.02020 1.000 23.84441 ? 67  LEU A CA  1 
ATOM   511  C C   . LEU A 1 67  ? -18.78188 20.61659 -46.37053 1.000 25.44676 ? 67  LEU A C   1 
ATOM   512  O O   . LEU A 1 67  ? -18.78077 20.93400 -45.17901 1.000 24.90536 ? 67  LEU A O   1 
ATOM   513  C CB  . LEU A 1 67  ? -21.24567 21.00178 -46.77195 1.000 31.83014 ? 67  LEU A CB  1 
ATOM   514  C CG  . LEU A 1 67  ? -21.00116 22.47832 -47.01798 1.000 38.24088 ? 67  LEU A CG  1 
ATOM   515  C CD1 . LEU A 1 67  ? -20.65539 22.74836 -48.47702 1.000 41.15251 ? 67  LEU A CD1 1 
ATOM   516  C CD2 . LEU A 1 67  ? -22.24543 23.25581 -46.59036 1.000 46.96403 ? 67  LEU A CD2 1 
ATOM   517  N N   . VAL A 1 68  ? -17.72039 20.72158 -47.15670 1.000 29.30480 ? 68  VAL A N   1 
ATOM   518  C CA  . VAL A 1 68  ? -16.39785 21.14435 -46.69384 1.000 23.41075 ? 68  VAL A CA  1 
ATOM   519  C C   . VAL A 1 68  ? -16.13716 22.52181 -47.26958 1.000 35.84339 ? 68  VAL A C   1 
ATOM   520  O O   . VAL A 1 68  ? -16.16367 22.70883 -48.49444 1.000 28.21286 ? 68  VAL A O   1 
ATOM   521  C CB  . VAL A 1 68  ? -15.31231 20.15394 -47.13268 1.000 22.16243 ? 68  VAL A CB  1 
ATOM   522  C CG1 . VAL A 1 68  ? -13.93270 20.60910 -46.65120 1.000 23.79204 ? 68  VAL A CG1 1 
ATOM   523  C CG2 . VAL A 1 68  ? -15.64419 18.77541 -46.57817 1.000 24.49489 ? 68  VAL A CG2 1 
ATOM   524  N N   . GLN A 1 69  ? -15.88751 23.49124 -46.40433 1.000 24.94360 ? 69  GLN A N   1 
ATOM   525  C CA  . GLN A 1 69  ? -15.63264 24.84165 -46.86932 1.000 26.80550 ? 69  GLN A CA  1 
ATOM   526  C C   . GLN A 1 69  ? -14.26996 25.28226 -46.38757 1.000 26.68129 ? 69  GLN A C   1 
ATOM   527  O O   . GLN A 1 69  ? -13.95148 25.15436 -45.19365 1.000 25.49960 ? 69  GLN A O   1 
ATOM   528  C CB  . GLN A 1 69  ? -16.69760 25.82264 -46.39845 1.000 33.18102 ? 69  GLN A CB  1 
ATOM   529  C CG  . GLN A 1 69  ? -18.09959 25.52053 -46.89162 1.000 47.67152 ? 69  GLN A CG  1 
ATOM   530  C CD  . GLN A 1 69  ? -19.06900 26.60230 -46.46012 1.000 54.53418 ? 69  GLN A CD  1 
ATOM   531  O OE1 . GLN A 1 69  ? -18.87348 27.77601 -46.77314 1.000 60.47292 ? 69  GLN A OE1 1 
ATOM   532  N NE2 . GLN A 1 69  ? -20.09419 26.22103 -45.70682 1.000 55.02366 ? 69  GLN A NE2 1 
ATOM   533  N N   . ALA A 1 70  ? -13.48388 25.80393 -47.31850 1.000 26.69799 ? 70  ALA A N   1 
ATOM   534  C CA  . ALA A 1 70  ? -12.15134 26.33836 -47.06265 1.000 24.23055 ? 70  ALA A CA  1 
ATOM   535  C C   . ALA A 1 70  ? -12.23331 27.80680 -47.45658 1.000 38.17385 ? 70  ALA A C   1 
ATOM   536  O O   . ALA A 1 70  ? -12.22147 28.13756 -48.64530 1.000 34.03714 ? 70  ALA A O   1 
ATOM   537  C CB  . ALA A 1 70  ? -11.09214 25.57635 -47.85139 1.000 23.95465 ? 70  ALA A CB  1 
ATOM   538  N N   . GLY A 1 71  ? -12.37392 28.68764 -46.47295 1.000 33.96931 ? 71  GLY A N   1 
ATOM   539  C CA  . GLY A 1 71  ? -12.71082 30.05793 -46.81749 1.000 46.98377 ? 71  GLY A CA  1 
ATOM   540  C C   . GLY A 1 71  ? -14.04808 30.10863 -47.53641 1.000 39.48382 ? 71  GLY A C   1 
ATOM   541  O O   . GLY A 1 71  ? -15.04255 29.52168 -47.09050 1.000 44.69731 ? 71  GLY A O   1 
ATOM   542  N N   . ASN A 1 72  ? -14.08145 30.80515 -48.67377 1.000 51.00738 ? 72  ASN A N   1 
ATOM   543  C CA  . ASN A 1 72  ? -15.29704 30.95303 -49.46750 1.000 48.22716 ? 72  ASN A CA  1 
ATOM   544  C C   . ASN A 1 72  ? -15.45444 29.86031 -50.51285 1.000 59.00540 ? 72  ASN A C   1 
ATOM   545  O O   . ASN A 1 72  ? -16.33046 29.96810 -51.37901 1.000 58.70913 ? 72  ASN A O   1 
ATOM   546  C CB  . ASN A 1 72  ? -15.32047 32.32029 -50.15750 1.000 55.40359 ? 72  ASN A CB  1 
ATOM   547  N N   . VAL A 1 73  ? -14.63631 28.81508 -50.44760 1.000 39.34542 ? 73  VAL A N   1 
ATOM   548  C CA  . VAL A 1 73  ? -14.56180 27.79156 -51.48066 1.000 36.51674 ? 73  VAL A CA  1 
ATOM   549  C C   . VAL A 1 73  ? -15.12530 26.49542 -50.92906 1.000 38.81656 ? 73  VAL A C   1 
ATOM   550  O O   . VAL A 1 73  ? -14.69932 26.02919 -49.87179 1.000 30.42751 ? 73  VAL A O   1 
ATOM   551  C CB  . VAL A 1 73  ? -13.11460 27.57894 -51.94660 1.000 41.00769 ? 73  VAL A CB  1 
ATOM   552  C CG1 . VAL A 1 73  ? -13.06150 26.52773 -53.05992 1.000 40.27381 ? 73  VAL A CG1 1 
ATOM   553  C CG2 . VAL A 1 73  ? -12.49166 28.90646 -52.35779 1.000 50.10466 ? 73  VAL A CG2 1 
ATOM   554  N N   . GLN A 1 74  ? -16.05047 25.89129 -51.65240 1.000 34.02436 ? 74  GLN A N   1 
ATOM   555  C CA  . GLN A 1 74  ? -16.50839 24.56684 -51.28311 1.000 28.76840 ? 74  GLN A CA  1 
ATOM   556  C C   . GLN A 1 74  ? -15.61554 23.52698 -51.94414 1.000 32.23031 ? 74  GLN A C   1 
ATOM   557  O O   . GLN A 1 74  ? -15.39603 23.57392 -53.15947 1.000 38.08317 ? 74  GLN A O   1 
ATOM   558  C CB  . GLN A 1 74  ? -17.96559 24.35994 -51.68766 1.000 28.96920 ? 74  GLN A CB  1 
ATOM   559  C CG  . GLN A 1 74  ? -18.48902 23.00822 -51.33962 1.000 41.62230 ? 74  GLN A CG  1 
ATOM   560  C CD  . GLN A 1 74  ? -19.91345 22.81679 -51.81295 1.000 58.06580 ? 74  GLN A CD  1 
ATOM   561  O OE1 . GLN A 1 74  ? -20.62303 23.78800 -52.08633 1.000 55.09614 ? 74  GLN A OE1 1 
ATOM   562  N NE2 . GLN A 1 74  ? -20.33563 21.56188 -51.92734 1.000 53.39576 ? 74  GLN A NE2 1 
ATOM   563  N N   . LEU A 1 75  ? -15.09466 22.60469 -51.13220 1.000 30.08412 ? 75  LEU A N   1 
ATOM   564  C CA  . LEU A 1 75  ? -14.27224 21.49060 -51.60527 1.000 27.58893 ? 75  LEU A CA  1 
ATOM   565  C C   . LEU A 1 75  ? -15.16575 20.29935 -51.89204 1.000 33.47302 ? 75  LEU A C   1 
ATOM   566  O O   . LEU A 1 75  ? -16.02397 19.94722 -51.08091 1.000 40.18560 ? 75  LEU A O   1 
ATOM   567  C CB  . LEU A 1 75  ? -13.25081 21.07746 -50.54848 1.000 24.68317 ? 75  LEU A CB  1 
ATOM   568  C CG  . LEU A 1 75  ? -12.29540 22.16629 -50.09262 1.000 30.68143 ? 75  LEU A CG  1 
ATOM   569  C CD1 . LEU A 1 75  ? -11.24719 21.58834 -49.14508 1.000 26.58361 ? 75  LEU A CD1 1 
ATOM   570  C CD2 . LEU A 1 75  ? -11.66206 22.82154 -51.31938 1.000 34.22865 ? 75  LEU A CD2 1 
ATOM   571  N N   . ARG A 1 76  ? -14.94670 19.65203 -53.02119 1.000 28.45156 ? 76  ARG A N   1 
ATOM   572  C CA  . ARG A 1 76  ? -15.80984 18.54693 -53.39895 1.000 30.73852 ? 76  ARG A CA  1 
ATOM   573  C C   . ARG A 1 76  ? -15.28550 17.25217 -52.79664 1.000 23.41054 ? 76  ARG A C   1 
ATOM   574  O O   . ARG A 1 76  ? -14.12500 16.88527 -53.01671 1.000 27.73039 ? 76  ARG A O   1 
ATOM   575  C CB  . ARG A 1 76  ? -15.90320 18.44386 -54.91606 1.000 34.49147 ? 76  ARG A CB  1 
ATOM   576  C CG  . ARG A 1 76  ? -16.76416 17.29697 -55.34767 1.000 37.16433 ? 76  ARG A CG  1 
ATOM   577  C CD  . ARG A 1 76  ? -17.04980 17.42644 -56.81739 1.000 35.70952 ? 76  ARG A CD  1 
ATOM   578  N NE  . ARG A 1 76  ? -17.97822 16.39335 -57.24185 1.000 38.50283 ? 76  ARG A NE  1 
ATOM   579  C CZ  . ARG A 1 76  ? -19.29863 16.47845 -57.13107 1.000 36.26022 ? 76  ARG A CZ  1 
ATOM   580  N NH1 . ARG A 1 76  ? -19.88277 17.53498 -56.59354 1.000 35.50002 ? 76  ARG A NH1 1 
ATOM   581  N NH2 . ARG A 1 76  ? -20.04871 15.47234 -57.56642 1.000 36.91133 ? 76  ARG A NH2 1 
ATOM   582  N N   . VAL A 1 77  ? -16.12075 16.58433 -52.00685 1.000 24.66354 ? 77  VAL A N   1 
ATOM   583  C CA  . VAL A 1 77  ? -15.73160 15.33353 -51.37322 1.000 25.86034 ? 77  VAL A CA  1 
ATOM   584  C C   . VAL A 1 77  ? -15.88272 14.19934 -52.37564 1.000 27.97312 ? 77  VAL A C   1 
ATOM   585  O O   . VAL A 1 77  ? -16.96925 13.99820 -52.93825 1.000 29.06004 ? 77  VAL A O   1 
ATOM   586  C CB  . VAL A 1 77  ? -16.57275 15.07169 -50.11665 1.000 26.16850 ? 77  VAL A CB  1 
ATOM   587  C CG1 . VAL A 1 77  ? -16.29410 13.68940 -49.60264 1.000 23.37447 ? 77  VAL A CG1 1 
ATOM   588  C CG2 . VAL A 1 77  ? -16.24184 16.10803 -49.03464 1.000 26.56013 ? 77  VAL A CG2 1 
ATOM   589  N N   . ILE A 1 78  ? -14.81069 13.42407 -52.56996 1.000 29.17759 ? 78  ILE A N   1 
ATOM   590  C CA  . ILE A 1 78  ? -14.82009 12.32120 -53.52467 1.000 26.73293 ? 78  ILE A CA  1 
ATOM   591  C C   . ILE A 1 78  ? -14.58244 10.96395 -52.86429 1.000 29.32071 ? 78  ILE A C   1 
ATOM   592  O O   . ILE A 1 78  ? -14.39657 9.97075  -53.56135 1.000 30.45560 ? 78  ILE A O   1 
ATOM   593  C CB  . ILE A 1 78  ? -13.80819 12.57245 -54.66607 1.000 25.75571 ? 78  ILE A CB  1 
ATOM   594  C CG1 . ILE A 1 78  ? -12.37149 12.63727 -54.13501 1.000 27.53515 ? 78  ILE A CG1 1 
ATOM   595  C CG2 . ILE A 1 78  ? -14.12374 13.88393 -55.34511 1.000 25.57314 ? 78  ILE A CG2 1 
ATOM   596  C CD1 . ILE A 1 78  ? -11.30608 12.54095 -55.23664 1.000 32.26815 ? 78  ILE A CD1 1 
ATOM   597  N N   . GLY A 1 79  ? -14.60106 10.89048 -51.53265 1.000 22.97236 ? 79  GLY A N   1 
ATOM   598  C CA  . GLY A 1 79  ? -14.40901 9.62891  -50.83628 1.000 26.42177 ? 79  GLY A CA  1 
ATOM   599  C C   . GLY A 1 79  ? -14.46319 9.88326  -49.34408 1.000 28.16974 ? 79  GLY A C   1 
ATOM   600  O O   . GLY A 1 79  ? -14.24371 11.00225 -48.88163 1.000 28.81209 ? 79  GLY A O   1 
ATOM   601  N N   . HIS A 1 80  ? -14.77221 8.82361  -48.59719 1.000 27.29854 ? 80  HIS A N   1 
ATOM   602  C CA  . HIS A 1 80  ? -14.83457 8.96630  -47.14443 1.000 29.74177 ? 80  HIS A CA  1 
ATOM   603  C C   . HIS A 1 80  ? -14.61861 7.61991  -46.48557 1.000 34.13365 ? 80  HIS A C   1 
ATOM   604  O O   . HIS A 1 80  ? -14.98656 6.57684  -47.02957 1.000 34.39164 ? 80  HIS A O   1 
ATOM   605  C CB  . HIS A 1 80  ? -16.17031 9.54767  -46.66725 1.000 27.16084 ? 80  HIS A CB  1 
ATOM   606  C CG  . HIS A 1 80  ? -17.35956 8.65652  -46.90602 1.000 29.55346 ? 80  HIS A CG  1 
ATOM   607  N ND1 . HIS A 1 80  ? -18.08735 8.68343  -48.08360 1.000 36.25047 ? 80  HIS A ND1 1 
ATOM   608  C CD2 . HIS A 1 80  ? -17.95306 7.72579  -46.11977 1.000 34.19784 ? 80  HIS A CD2 1 
ATOM   609  C CE1 . HIS A 1 80  ? -19.07677 7.80697  -48.00700 1.000 34.96320 ? 80  HIS A CE1 1 
ATOM   610  N NE2 . HIS A 1 80  ? -19.01641 7.21248  -46.82522 1.000 32.76559 ? 80  HIS A NE2 1 
ATOM   611  N N   . SER A 1 81  ? -14.01945 7.65513  -45.30206 1.000 27.22417 ? 81  SER A N   1 
ATOM   612  C CA  . SER A 1 81  ? -13.86346 6.45252  -44.50964 1.000 23.70279 ? 81  SER A CA  1 
ATOM   613  C C   . SER A 1 81  ? -13.67294 6.88892  -43.06731 1.000 29.24111 ? 81  SER A C   1 
ATOM   614  O O   . SER A 1 81  ? -13.45998 8.06961  -42.78263 1.000 29.88939 ? 81  SER A O   1 
ATOM   615  C CB  . SER A 1 81  ? -12.68040 5.60756  -44.96203 1.000 26.18738 ? 81  SER A CB  1 
ATOM   616  O OG  . SER A 1 81  ? -11.46956 6.31380  -44.79558 1.000 34.58685 ? 81  SER A OG  1 
ATOM   617  N N   . MET A 1 82  ? -13.72581 5.91308  -42.16922 1.000 26.41949 ? 82  MET A N   1 
ATOM   618  C CA  . MET A 1 82  ? -13.62097 6.16441  -40.74268 1.000 27.89835 ? 82  MET A CA  1 
ATOM   619  C C   . MET A 1 82  ? -12.44233 5.38017  -40.19089 1.000 32.36819 ? 82  MET A C   1 
ATOM   620  O O   . MET A 1 82  ? -12.28840 4.19395  -40.48892 1.000 33.36049 ? 82  MET A O   1 
ATOM   621  C CB  . MET A 1 82  ? -14.91510 5.77314  -40.02847 1.000 25.05994 ? 82  MET A CB  1 
ATOM   622  C CG  . MET A 1 82  ? -14.85810 5.99357  -38.54819 1.000 28.02460 ? 82  MET A CG  1 
ATOM   623  S SD  . MET A 1 82  ? -16.49916 5.88470  -37.77227 1.000 34.40748 ? 82  MET A SD  1 
ATOM   624  C CE  . MET A 1 82  ? -16.89501 4.13063  -37.87155 1.000 33.32975 ? 82  MET A CE  1 
ATOM   625  N N   . GLN A 1 83  ? -11.61036 6.02969  -39.38384 1.000 22.52328 ? 83  GLN A N   1 
ATOM   626  C CA  . GLN A 1 83  ? -10.46834 5.36232  -38.77505 1.000 24.12398 ? 83  GLN A CA  1 
ATOM   627  C C   . GLN A 1 83  ? -10.53957 5.65531  -37.27675 1.000 28.82503 ? 83  GLN A C   1 
ATOM   628  O O   . GLN A 1 83  ? -10.27948 6.78490  -36.85417 1.000 29.11070 ? 83  GLN A O   1 
ATOM   629  C CB  . GLN A 1 83  ? -9.15219  5.85073  -39.35869 1.000 29.60961 ? 83  GLN A CB  1 
ATOM   630  C CG  . GLN A 1 83  ? -7.93475  5.29924  -38.61221 1.000 26.10564 ? 83  GLN A CG  1 
ATOM   631  C CD  . GLN A 1 83  ? -6.61818  5.74631  -39.23285 1.000 29.51147 ? 83  GLN A CD  1 
ATOM   632  O OE1 . GLN A 1 83  ? -6.56594  6.70261  -40.01020 1.000 32.79376 ? 83  GLN A OE1 1 
ATOM   633  N NE2 . GLN A 1 83  ? -5.54672  5.06109  -38.88507 1.000 29.97870 ? 83  GLN A NE2 1 
ATOM   634  N N   . ASN A 1 84  ? -10.93792 4.66181  -36.48678 1.000 26.90048 ? 84  ASN A N   1 
ATOM   635  C CA  . ASN A 1 84  ? -11.21273 4.89872  -35.07351 1.000 24.26777 ? 84  ASN A CA  1 
ATOM   636  C C   . ASN A 1 84  ? -12.16869 6.08580  -34.92434 1.000 24.15731 ? 84  ASN A C   1 
ATOM   637  O O   . ASN A 1 84  ? -13.26243 6.06176  -35.49724 1.000 24.69876 ? 84  ASN A O   1 
ATOM   638  C CB  . ASN A 1 84  ? -9.90067  5.08955  -34.32656 1.000 33.09563 ? 84  ASN A CB  1 
ATOM   639  C CG  . ASN A 1 84  ? -8.96023  3.91059  -34.53151 1.000 32.85723 ? 84  ASN A CG  1 
ATOM   640  O OD1 . ASN A 1 84  ? -9.33462  2.76467  -34.28842 1.000 33.14092 ? 84  ASN A OD1 1 
ATOM   641  N ND2 . ASN A 1 84  ? -7.75537  4.18424  -35.00685 1.000 27.50310 ? 84  ASN A ND2 1 
ATOM   642  N N   . CYS A 1 85  ? -11.80393 7.13479  -34.17115 1.000 23.00194 ? 85  CYS A N   1 
ATOM   643  C CA  . CYS A 1 85  ? -12.76813 8.20868  -33.93433 1.000 19.02026 ? 85  CYS A CA  1 
ATOM   644  C C   . CYS A 1 85  ? -12.63050 9.37955  -34.90165 1.000 25.17525 ? 85  CYS A C   1 
ATOM   645  O O   . CYS A 1 85  ? -13.22524 10.43756 -34.66235 1.000 22.12203 ? 85  CYS A O   1 
ATOM   646  C CB  . CYS A 1 85  ? -12.66822 8.70826  -32.48542 1.000 21.23484 ? 85  CYS A CB  1 
ATOM   647  S SG  . CYS A 1 85  ? -12.95992 7.40277  -31.28617 1.000 27.51337 ? 85  CYS A SG  1 
ATOM   648  N N   . VAL A 1 86  ? -11.89829 9.21440  -36.01114 1.000 21.08402 ? 86  VAL A N   1 
ATOM   649  C CA  . VAL A 1 86  ? -11.71227 10.27412 -36.99338 1.000 21.04452 ? 86  VAL A CA  1 
ATOM   650  C C   . VAL A 1 86  ? -12.36815 9.85221  -38.29969 1.000 25.45029 ? 86  VAL A C   1 
ATOM   651  O O   . VAL A 1 86  ? -12.32984 8.67421  -38.66655 1.000 27.96783 ? 86  VAL A O   1 
ATOM   652  C CB  . VAL A 1 86  ? -10.20904 10.57781 -37.18214 1.000 27.37565 ? 86  VAL A CB  1 
ATOM   653  C CG1 . VAL A 1 86  ? -9.92372  11.22022 -38.53799 1.000 42.78286 ? 86  VAL A CG1 1 
ATOM   654  C CG2 . VAL A 1 86  ? -9.73073  11.46476 -36.01859 1.000 26.35831 ? 86  VAL A CG2 1 
ATOM   655  N N   . LEU A 1 87  ? -12.97881 10.81149 -38.98378 1.000 22.41776 ? 87  LEU A N   1 
ATOM   656  C CA  . LEU A 1 87  ? -13.36866 10.64051 -40.37343 1.000 19.76904 ? 87  LEU A CA  1 
ATOM   657  C C   . LEU A 1 87  ? -12.28333 11.17848 -41.27013 1.000 26.96490 ? 87  LEU A C   1 
ATOM   658  O O   . LEU A 1 87  ? -11.68712 12.21836 -40.97935 1.000 28.49841 ? 87  LEU A O   1 
ATOM   659  C CB  . LEU A 1 87  ? -14.65097 11.39209 -40.70628 1.000 26.44059 ? 87  LEU A CB  1 
ATOM   660  C CG  . LEU A 1 87  ? -15.98780 10.90223 -40.22402 1.000 37.01363 ? 87  LEU A CG  1 
ATOM   661  C CD1 . LEU A 1 87  ? -17.02486 11.82292 -40.84693 1.000 32.48096 ? 87  LEU A CD1 1 
ATOM   662  C CD2 . LEU A 1 87  ? -16.14937 9.45390  -40.65594 1.000 38.87501 ? 87  LEU A CD2 1 
ATOM   663  N N   . LYS A 1 88  ? -12.07206 10.50118 -42.39756 1.000 24.94560 ? 88  LYS A N   1 
ATOM   664  C CA  . LYS A 1 88  ? -11.16740 10.97129 -43.42904 1.000 27.12550 ? 88  LYS A CA  1 
ATOM   665  C C   . LYS A 1 88  ? -12.01494 11.20876 -44.66468 1.000 23.90675 ? 88  LYS A C   1 
ATOM   666  O O   . LYS A 1 88  ? -12.66936 10.28166 -45.15426 1.000 29.02679 ? 88  LYS A O   1 
ATOM   667  C CB  . LYS A 1 88  ? -10.02683 9.96972  -43.67102 1.000 24.80750 ? 88  LYS A CB  1 
ATOM   668  C CG  . LYS A 1 88  ? -9.11825  9.83031  -42.42596 1.000 26.54183 ? 88  LYS A CG  1 
ATOM   669  C CD  . LYS A 1 88  ? -8.57888  8.43234  -42.22876 1.000 43.00801 ? 88  LYS A CD  1 
ATOM   670  C CE  . LYS A 1 88  ? -7.56574  8.08886  -43.26234 1.000 42.47123 ? 88  LYS A CE  1 
ATOM   671  N NZ  . LYS A 1 88  ? -6.98380  6.76146  -42.97435 1.000 34.97112 ? 88  LYS A NZ  1 
ATOM   672  N N   . LEU A 1 89  ? -12.08308 12.46437 -45.10900 1.000 21.73153 ? 89  LEU A N   1 
ATOM   673  C CA  . LEU A 1 89  ? -12.82180 12.82393 -46.32456 1.000 23.64447 ? 89  LEU A CA  1 
ATOM   674  C C   . LEU A 1 89  ? -11.81764 13.13006 -47.41204 1.000 23.95738 ? 89  LEU A C   1 
ATOM   675  O O   . LEU A 1 89  ? -11.06543 14.10159 -47.30433 1.000 23.51871 ? 89  LEU A O   1 
ATOM   676  C CB  . LEU A 1 89  ? -13.73757 14.02660 -46.12214 1.000 21.12471 ? 89  LEU A CB  1 
ATOM   677  C CG  . LEU A 1 89  ? -14.60120 13.86557 -44.88501 1.000 25.40707 ? 89  LEU A CG  1 
ATOM   678  C CD1 . LEU A 1 89  ? -15.21926 15.19659 -44.56858 1.000 29.20515 ? 89  LEU A CD1 1 
ATOM   679  C CD2 . LEU A 1 89  ? -15.67484 12.83019 -45.17236 1.000 28.94264 ? 89  LEU A CD2 1 
ATOM   680  N N   . LYS A 1 90  ? -11.82331 12.32847 -48.48048 1.000 23.59719 ? 90  LYS A N   1 
ATOM   681  C CA  . LYS A 1 90  ? -10.97034 12.62654 -49.62084 1.000 23.77237 ? 90  LYS A CA  1 
ATOM   682  C C   . LYS A 1 90  ? -11.62312 13.72525 -50.45328 1.000 21.40316 ? 90  LYS A C   1 
ATOM   683  O O   . LYS A 1 90  ? -12.82971 13.67656 -50.71796 1.000 25.06735 ? 90  LYS A O   1 
ATOM   684  C CB  . LYS A 1 90  ? -10.75127 11.36051 -50.45573 1.000 24.53910 ? 90  LYS A CB  1 
ATOM   685  C CG  . LYS A 1 90  ? -9.72158  11.54283 -51.55025 1.000 29.67481 ? 90  LYS A CG  1 
ATOM   686  C CD  . LYS A 1 90  ? -9.40823  10.20525 -52.23001 1.000 37.90417 ? 90  LYS A CD  1 
ATOM   687  C CE  . LYS A 1 90  ? -8.21423  10.35844 -53.16386 1.000 40.90710 ? 90  LYS A CE  1 
ATOM   688  N NZ  . LYS A 1 90  ? -8.11745  9.18579  -54.07287 1.000 51.65301 ? 90  LYS A NZ  1 
ATOM   689  N N   . VAL A 1 91  ? -10.85992 14.76030 -50.79662 1.000 23.45354 ? 91  VAL A N   1 
ATOM   690  C CA  . VAL A 1 91  ? -11.38042 15.85448 -51.60139 1.000 26.23331 ? 91  VAL A CA  1 
ATOM   691  C C   . VAL A 1 91  ? -10.63969 15.89155 -52.94590 1.000 21.58474 ? 91  VAL A C   1 
ATOM   692  O O   . VAL A 1 91  ? -9.55486  15.31863 -53.11082 1.000 27.29502 ? 91  VAL A O   1 
ATOM   693  C CB  . VAL A 1 91  ? -11.30114 17.20161 -50.84526 1.000 24.61127 ? 91  VAL A CB  1 
ATOM   694  C CG1 . VAL A 1 91  ? -12.21053 17.12785 -49.62975 1.000 26.51633 ? 91  VAL A CG1 1 
ATOM   695  C CG2 . VAL A 1 91  ? -9.84593  17.55103 -50.40140 1.000 20.39613 ? 91  VAL A CG2 1 
ATOM   696  N N   . ASP A 1 92  ? -11.24047 16.57199 -53.92046 1.000 24.13685 ? 92  ASP A N   1 
ATOM   697  C CA  . ASP A 1 92  ? -10.63752 16.53602 -55.25347 1.000 24.97912 ? 92  ASP A CA  1 
ATOM   698  C C   . ASP A 1 92  ? -9.56041  17.59247 -55.45939 1.000 33.16228 ? 92  ASP A C   1 
ATOM   699  O O   . ASP A 1 92  ? -9.01230  17.68569 -56.55893 1.000 26.76224 ? 92  ASP A O   1 
ATOM   700  C CB  . ASP A 1 92  ? -11.73482 16.64336 -56.33583 1.000 32.65515 ? 92  ASP A CB  1 
ATOM   701  C CG  . ASP A 1 92  ? -12.39272 18.02505 -56.41560 1.000 45.68064 ? 92  ASP A CG  1 
ATOM   702  O OD1 . ASP A 1 92  ? -11.96272 18.95416 -55.71494 1.000 34.58777 ? 92  ASP A OD1 1 
ATOM   703  O OD2 . ASP A 1 92  ? -13.35325 18.18820 -57.21078 1.000 40.18010 ? 92  ASP A OD2 1 
ATOM   704  N N   . THR A 1 93  ? -9.19830  18.33486 -54.41543 1.000 29.13451 ? 93  THR A N   1 
ATOM   705  C CA  . THR A 1 93  ? -8.23103  19.42364 -54.47370 1.000 27.16571 ? 93  THR A CA  1 
ATOM   706  C C   . THR A 1 93  ? -7.20061  19.18728 -53.37788 1.000 27.80917 ? 93  THR A C   1 
ATOM   707  O O   . THR A 1 93  ? -7.57518  18.89785 -52.23781 1.000 25.30028 ? 93  THR A O   1 
ATOM   708  C CB  . THR A 1 93  ? -8.94019  20.77056 -54.25105 1.000 26.61036 ? 93  THR A CB  1 
ATOM   709  O OG1 . THR A 1 93  ? -9.88740  20.98831 -55.30440 1.000 35.36107 ? 93  THR A OG1 1 
ATOM   710  C CG2 . THR A 1 93  ? -7.95977  21.91727 -54.22450 1.000 27.36640 ? 93  THR A CG2 1 
ATOM   711  N N   . ALA A 1 94  ? -5.92028  19.29967 -53.71039 1.000 22.87494 ? 94  ALA A N   1 
ATOM   712  C CA  . ALA A 1 94  ? -4.89021  19.20608 -52.67437 1.000 24.66567 ? 94  ALA A CA  1 
ATOM   713  C C   . ALA A 1 94  ? -4.71764  20.56739 -52.02090 1.000 18.91710 ? 94  ALA A C   1 
ATOM   714  O O   . ALA A 1 94  ? -4.78470  21.60199 -52.69689 1.000 23.67104 ? 94  ALA A O   1 
ATOM   715  C CB  . ALA A 1 94  ? -3.55921  18.73903 -53.27201 1.000 27.27729 ? 94  ALA A CB  1 
ATOM   716  N N   . ASN A 1 95  ? -4.50476  20.58441 -50.68649 1.000 23.90478 ? 95  ASN A N   1 
ATOM   717  C CA  . ASN A 1 95  ? -4.34465  21.88589 -50.03035 1.000 22.68754 ? 95  ASN A CA  1 
ATOM   718  C C   . ASN A 1 95  ? -3.01027  22.50291 -50.43074 1.000 23.41180 ? 95  ASN A C   1 
ATOM   719  O O   . ASN A 1 95  ? -1.95873  21.95104 -50.07309 1.000 27.57210 ? 95  ASN A O   1 
ATOM   720  C CB  . ASN A 1 95  ? -4.42481  21.74707 -48.48254 1.000 22.35380 ? 95  ASN A CB  1 
ATOM   721  C CG  . ASN A 1 95  ? -4.28413  23.08125 -47.76122 1.000 20.16793 ? 95  ASN A CG  1 
ATOM   722  O OD1 . ASN A 1 95  ? -4.18716  24.14298 -48.38539 1.000 23.80476 ? 95  ASN A OD1 1 
ATOM   723  N ND2 . ASN A 1 95  ? -4.34388  23.03678 -46.42306 1.000 25.57947 ? 95  ASN A ND2 1 
ATOM   724  N N   . PRO A 1 96  ? -2.99049  23.63911 -51.13340 1.000 24.59962 ? 96  PRO A N   1 
ATOM   725  C CA  . PRO A 1 96  ? -1.69826  24.19714 -51.55825 1.000 27.12672 ? 96  PRO A CA  1 
ATOM   726  C C   . PRO A 1 96  ? -0.85184  24.70031 -50.39865 1.000 27.49963 ? 96  PRO A C   1 
ATOM   727  O O   . PRO A 1 96  ? 0.36941   24.86078 -50.56801 1.000 26.99381 ? 96  PRO A O   1 
ATOM   728  C CB  . PRO A 1 96  ? -2.09802  25.33660 -52.50769 1.000 27.97683 ? 96  PRO A CB  1 
ATOM   729  C CG  . PRO A 1 96  ? -3.47157  25.71445 -52.09825 1.000 29.27349 ? 96  PRO A CG  1 
ATOM   730  C CD  . PRO A 1 96  ? -4.12946  24.45914 -51.59004 1.000 26.78827 ? 96  PRO A CD  1 
ATOM   731  N N   . LYS A 1 97  ? -1.45343  24.93083 -49.22600 1.000 22.71113 ? 97  LYS A N   1 
ATOM   732  C CA  . LYS A 1 97  ? -0.73477  25.37743 -48.04307 1.000 23.04811 ? 97  LYS A CA  1 
ATOM   733  C C   . LYS A 1 97  ? -0.32047  24.23901 -47.12453 1.000 23.46823 ? 97  LYS A C   1 
ATOM   734  O O   . LYS A 1 97  ? 0.06078   24.50748 -45.98337 1.000 23.91281 ? 97  LYS A O   1 
ATOM   735  C CB  . LYS A 1 97  ? -1.60455  26.35851 -47.24490 1.000 23.54724 ? 97  LYS A CB  1 
ATOM   736  C CG  . LYS A 1 97  ? -2.01912  27.57813 -48.03387 1.000 25.64378 ? 97  LYS A CG  1 
ATOM   737  C CD  . LYS A 1 97  ? -3.06495  28.39221 -47.28682 1.000 29.90295 ? 97  LYS A CD  1 
ATOM   738  C CE  . LYS A 1 97  ? -3.20430  29.76889 -47.89488 1.000 42.68237 ? 97  LYS A CE  1 
ATOM   739  N NZ  . LYS A 1 97  ? -4.30927  30.53497 -47.25378 1.000 44.25940 ? 97  LYS A NZ  1 
ATOM   740  N N   . THR A 1 98  ? -0.39293  22.99158 -47.57126 1.000 20.91828 ? 98  THR A N   1 
ATOM   741  C CA  . THR A 1 98  ? -0.01213  21.87533 -46.71164 1.000 24.82503 ? 98  THR A CA  1 
ATOM   742  C C   . THR A 1 98  ? 1.43910   22.03504 -46.26896 1.000 26.11295 ? 98  THR A C   1 
ATOM   743  O O   . THR A 1 98  ? 2.32415   22.16407 -47.12722 1.000 25.99509 ? 98  THR A O   1 
ATOM   744  C CB  . THR A 1 98  ? -0.18165  20.55716 -47.46996 1.000 23.56827 ? 98  THR A CB  1 
ATOM   745  O OG1 . THR A 1 98  ? -1.54328  20.43795 -47.90469 1.000 23.78663 ? 98  THR A OG1 1 
ATOM   746  C CG2 . THR A 1 98  ? 0.14601   19.36781 -46.60403 1.000 24.39522 ? 98  THR A CG2 1 
ATOM   747  N N   . PRO A 1 99  ? 1.72995   22.01348 -44.97579 1.000 21.55712 ? 99  PRO A N   1 
ATOM   748  C CA  . PRO A 1 99  ? 3.11637   22.05821 -44.52574 1.000 21.49053 ? 99  PRO A CA  1 
ATOM   749  C C   . PRO A 1 99  ? 3.70381   20.66480 -44.57253 1.000 18.80060 ? 99  PRO A C   1 
ATOM   750  O O   . PRO A 1 99  ? 2.98639   19.67285 -44.69650 1.000 25.47228 ? 99  PRO A O   1 
ATOM   751  C CB  . PRO A 1 99  ? 3.01050   22.56136 -43.06444 1.000 20.78323 ? 99  PRO A CB  1 
ATOM   752  C CG  . PRO A 1 99  ? 1.67704   22.07113 -42.60838 1.000 18.92021 ? 99  PRO A CG  1 
ATOM   753  C CD  . PRO A 1 99  ? 0.77052   21.99847 -43.85782 1.000 20.43572 ? 99  PRO A CD  1 
ATOM   754  N N   . LYS A 1 100 ? 5.03491   20.59112 -44.41754 1.000 21.88196 ? 100 LYS A N   1 
ATOM   755  C CA  . LYS A 1 100 ? 5.61410   19.30328 -44.07131 1.000 19.44150 ? 100 LYS A CA  1 
ATOM   756  C C   . LYS A 1 100 ? 5.03100   18.89236 -42.71878 1.000 27.87445 ? 100 LYS A C   1 
ATOM   757  O O   . LYS A 1 100 ? 4.95208   19.72641 -41.81815 1.000 24.89757 ? 100 LYS A O   1 
ATOM   758  C CB  . LYS A 1 100 ? 7.14780   19.39148 -43.98742 1.000 23.77107 ? 100 LYS A CB  1 
ATOM   759  C CG  . LYS A 1 100 ? 7.81907   18.05742 -43.67594 1.000 24.76931 ? 100 LYS A CG  1 
ATOM   760  C CD  . LYS A 1 100 ? 9.33270   18.23389 -43.55479 1.000 37.65370 ? 100 LYS A CD  1 
ATOM   761  C CE  . LYS A 1 100 ? 10.03016  16.92055 -43.27003 1.000 35.38244 ? 100 LYS A CE  1 
ATOM   762  N NZ  . LYS A 1 100 ? 11.49897  17.13539 -43.38206 1.000 41.35607 ? 100 LYS A NZ  1 
ATOM   763  N N   . TYR A 1 101 ? 4.61289   17.62976 -42.57160 1.000 24.67264 ? 101 TYR A N   1 
ATOM   764  C CA  . TYR A 1 101 ? 3.92725   17.23171 -41.34563 1.000 25.89801 ? 101 TYR A CA  1 
ATOM   765  C C   . TYR A 1 101 ? 4.11602   15.75145 -41.06371 1.000 30.12110 ? 101 TYR A C   1 
ATOM   766  O O   . TYR A 1 101 ? 4.49613   14.97311 -41.94136 1.000 27.06637 ? 101 TYR A O   1 
ATOM   767  C CB  . TYR A 1 101 ? 2.40634   17.52970 -41.40069 1.000 22.77402 ? 101 TYR A CB  1 
ATOM   768  C CG  . TYR A 1 101 ? 1.63813   16.59452 -42.31571 1.000 22.42359 ? 101 TYR A CG  1 
ATOM   769  C CD1 . TYR A 1 101 ? 1.58688   16.83583 -43.69458 1.000 25.88959 ? 101 TYR A CD1 1 
ATOM   770  C CD2 . TYR A 1 101 ? 1.03601   15.45265 -41.82392 1.000 23.70534 ? 101 TYR A CD2 1 
ATOM   771  C CE1 . TYR A 1 101 ? 0.88723   15.99689 -44.53285 1.000 28.70271 ? 101 TYR A CE1 1 
ATOM   772  C CE2 . TYR A 1 101 ? 0.33524   14.60651 -42.66054 1.000 31.29235 ? 101 TYR A CE2 1 
ATOM   773  C CZ  . TYR A 1 101 ? 0.27641   14.88133 -44.00806 1.000 30.55885 ? 101 TYR A CZ  1 
ATOM   774  O OH  . TYR A 1 101 ? -0.40946  14.04510 -44.85801 1.000 39.42386 ? 101 TYR A OH  1 
ATOM   775  N N   . LYS A 1 102 ? 3.82144   15.37275 -39.81360 1.000 21.04907 ? 102 LYS A N   1 
ATOM   776  C CA  . LYS A 1 102 ? 3.65028   13.98968 -39.42811 1.000 20.20210 ? 102 LYS A CA  1 
ATOM   777  C C   . LYS A 1 102 ? 2.61047   13.89829 -38.31818 1.000 20.71757 ? 102 LYS A C   1 
ATOM   778  O O   . LYS A 1 102 ? 2.24745   14.89893 -37.69401 1.000 21.40418 ? 102 LYS A O   1 
ATOM   779  C CB  . LYS A 1 102 ? 4.96644   13.33565 -39.00411 1.000 35.21360 ? 102 LYS A CB  1 
ATOM   780  C CG  . LYS A 1 102 ? 5.71493   14.02158 -37.91991 1.000 38.12763 ? 102 LYS A CG  1 
ATOM   781  C CD  . LYS A 1 102 ? 7.17211   13.53576 -37.86788 1.000 34.33634 ? 102 LYS A CD  1 
ATOM   782  C CE  . LYS A 1 102 ? 7.95324   14.33960 -36.83206 1.000 47.76245 ? 102 LYS A CE  1 
ATOM   783  N NZ  . LYS A 1 102 ? 7.50050   14.18793 -35.40996 1.000 51.55818 ? 102 LYS A NZ  1 
ATOM   784  N N   . PHE A 1 103 ? 2.10040   12.69708 -38.12102 1.000 22.28122 ? 103 PHE A N   1 
ATOM   785  C CA  . PHE A 1 103 ? 1.16658   12.40748 -37.04031 1.000 22.58808 ? 103 PHE A CA  1 
ATOM   786  C C   . PHE A 1 103 ? 1.93984   11.69397 -35.94372 1.000 26.16730 ? 103 PHE A C   1 
ATOM   787  O O   . PHE A 1 103 ? 2.59137   10.67557 -36.20364 1.000 25.98805 ? 103 PHE A O   1 
ATOM   788  C CB  . PHE A 1 103 ? 0.01294   11.52371 -37.51237 1.000 20.03925 ? 103 PHE A CB  1 
ATOM   789  C CG  . PHE A 1 103 ? -0.94960  12.19101 -38.46923 1.000 23.77477 ? 103 PHE A CG  1 
ATOM   790  C CD1 . PHE A 1 103 ? -0.91618  13.56399 -38.67773 1.000 18.50778 ? 103 PHE A CD1 1 
ATOM   791  C CD2 . PHE A 1 103 ? -1.88070  11.43158 -39.17435 1.000 20.73351 ? 103 PHE A CD2 1 
ATOM   792  C CE1 . PHE A 1 103 ? -1.82413  14.17362 -39.55253 1.000 22.13205 ? 103 PHE A CE1 1 
ATOM   793  C CE2 . PHE A 1 103 ? -2.80760  12.04655 -40.02964 1.000 21.79919 ? 103 PHE A CE2 1 
ATOM   794  C CZ  . PHE A 1 103 ? -2.76986  13.41239 -40.21768 1.000 21.78881 ? 103 PHE A CZ  1 
ATOM   795  N N   . VAL A 1 104 ? 1.87956   12.22059 -34.72131 1.000 23.09484 ? 104 VAL A N   1 
ATOM   796  C CA  . VAL A 1 104 ? 2.57887   11.58439 -33.61860 1.000 21.23935 ? 104 VAL A CA  1 
ATOM   797  C C   . VAL A 1 104 ? 1.58359   11.35417 -32.49994 1.000 25.63575 ? 104 VAL A C   1 
ATOM   798  O O   . VAL A 1 104 ? 0.53039   11.99401 -32.42463 1.000 26.43278 ? 104 VAL A O   1 
ATOM   799  C CB  . VAL A 1 104 ? 3.77422   12.41094 -33.10294 1.000 27.77709 ? 104 VAL A CB  1 
ATOM   800  C CG1 . VAL A 1 104 ? 4.78648   12.65348 -34.24958 1.000 28.83660 ? 104 VAL A CG1 1 
ATOM   801  C CG2 . VAL A 1 104 ? 3.28062   13.71949 -32.49931 1.000 27.61466 ? 104 VAL A CG2 1 
ATOM   802  N N   . ARG A 1 105 ? 1.90627   10.38639 -31.66010 1.000 21.58469 ? 105 ARG A N   1 
ATOM   803  C CA  . ARG A 1 105 ? 1.17297   10.16299 -30.42529 1.000 25.99248 ? 105 ARG A CA  1 
ATOM   804  C C   . ARG A 1 105 ? 2.07167   10.58932 -29.27627 1.000 26.80167 ? 105 ARG A C   1 
ATOM   805  O O   . ARG A 1 105 ? 3.17152   10.04667 -29.11302 1.000 27.94881 ? 105 ARG A O   1 
ATOM   806  C CB  . ARG A 1 105 ? 0.75904   8.70476  -30.27251 1.000 31.01038 ? 105 ARG A CB  1 
ATOM   807  C CG  . ARG A 1 105 ? -0.21897  8.54395  -29.14762 1.000 33.86734 ? 105 ARG A CG  1 
ATOM   808  C CD  . ARG A 1 105 ? -0.80977  7.18323  -29.09423 1.000 29.70802 ? 105 ARG A CD  1 
ATOM   809  N NE  . ARG A 1 105 ? -1.60683  7.03542  -27.87579 1.000 25.25804 ? 105 ARG A NE  1 
ATOM   810  C CZ  . ARG A 1 105 ? -2.90922  7.27654  -27.80392 1.000 26.68883 ? 105 ARG A CZ  1 
ATOM   811  N NH1 . ARG A 1 105 ? -3.58513  7.73302  -28.84188 1.000 26.48792 ? 105 ARG A NH1 1 
ATOM   812  N NH2 . ARG A 1 105 ? -3.54331  7.08071  -26.65248 1.000 27.40308 ? 105 ARG A NH2 1 
ATOM   813  N N   . ILE A 1 106 ? 1.63728   11.57632 -28.49670 1.000 26.82421 ? 106 ILE A N   1 
ATOM   814  C CA  . ILE A 1 106 ? 2.58023   12.06667 -27.49018 1.000 28.11930 ? 106 ILE A CA  1 
ATOM   815  C C   . ILE A 1 106 ? 2.36777   11.32852 -26.18337 1.000 23.02149 ? 106 ILE A C   1 
ATOM   816  O O   . ILE A 1 106 ? 1.41311   10.56038 -26.03310 1.000 24.89707 ? 106 ILE A O   1 
ATOM   817  C CB  . ILE A 1 106 ? 2.50351   13.59312 -27.29942 1.000 25.98672 ? 106 ILE A CB  1 
ATOM   818  C CG1 . ILE A 1 106 ? 1.08654   14.05298 -27.03041 1.000 27.14528 ? 106 ILE A CG1 1 
ATOM   819  C CG2 . ILE A 1 106 ? 3.08780   14.31330 -28.54092 1.000 32.92108 ? 106 ILE A CG2 1 
ATOM   820  C CD1 . ILE A 1 106 ? 1.07046   15.49954 -26.52670 1.000 29.53177 ? 106 ILE A CD1 1 
ATOM   821  N N   . GLN A 1 107 ? 3.28089   11.53299 -25.24066 1.000 27.72323 ? 107 GLN A N   1 
ATOM   822  C CA  . GLN A 1 107 ? 3.22784   10.88915 -23.94993 1.000 29.14324 ? 107 GLN A CA  1 
ATOM   823  C C   . GLN A 1 107 ? 2.77011   11.88408 -22.89615 1.000 25.40888 ? 107 GLN A C   1 
ATOM   824  O O   . GLN A 1 107 ? 2.93411   13.09297 -23.06206 1.000 23.59063 ? 107 GLN A O   1 
ATOM   825  C CB  . GLN A 1 107 ? 4.60943   10.33846 -23.57468 1.000 34.92778 ? 107 GLN A CB  1 
ATOM   826  C CG  . GLN A 1 107 ? 4.98066   9.03383  -24.27559 1.000 50.94718 ? 107 GLN A CG  1 
ATOM   827  C CD  . GLN A 1 107 ? 4.71482   7.82248  -23.40035 1.000 62.44399 ? 107 GLN A CD  1 
ATOM   828  O OE1 . GLN A 1 107 ? 3.64604   7.21166  -23.47113 1.000 70.06127 ? 107 GLN A OE1 1 
ATOM   829  N NE2 . GLN A 1 107 ? 5.68725   7.47410  -22.55908 1.000 66.15032 ? 107 GLN A NE2 1 
ATOM   830  N N   . PRO A 1 108 ? 2.18806   11.41190 -21.80093 1.000 26.15087 ? 108 PRO A N   1 
ATOM   831  C CA  . PRO A 1 108 ? 1.82599   12.32836 -20.71586 1.000 25.65555 ? 108 PRO A CA  1 
ATOM   832  C C   . PRO A 1 108 ? 3.04869   13.10429 -20.26869 1.000 22.81835 ? 108 PRO A C   1 
ATOM   833  O O   . PRO A 1 108 ? 4.16548   12.58252 -20.24425 1.000 30.84959 ? 108 PRO A O   1 
ATOM   834  C CB  . PRO A 1 108 ? 1.30977   11.39570 -19.60855 1.000 24.67233 ? 108 PRO A CB  1 
ATOM   835  C CG  . PRO A 1 108 ? 0.97288   10.13429 -20.28594 1.000 36.92412 ? 108 PRO A CG  1 
ATOM   836  C CD  . PRO A 1 108 ? 1.92277   10.00762 -21.44755 1.000 37.13004 ? 108 PRO A CD  1 
ATOM   837  N N   . GLY A 1 109 ? 2.84218   14.36767 -19.93793 1.000 21.77267 ? 109 GLY A N   1 
ATOM   838  C CA  . GLY A 1 109 ? 3.92551   15.23696 -19.58151 1.000 20.46478 ? 109 GLY A CA  1 
ATOM   839  C C   . GLY A 1 109 ? 4.45269   16.08793 -20.71322 1.000 27.80562 ? 109 GLY A C   1 
ATOM   840  O O   . GLY A 1 109 ? 5.07322   17.11350 -20.44605 1.000 26.46167 ? 109 GLY A O   1 
ATOM   841  N N   . GLN A 1 110 ? 4.27323   15.66682 -21.96782 1.000 20.28807 ? 110 GLN A N   1 
ATOM   842  C CA  . GLN A 1 110 ? 4.66726   16.46596 -23.11320 1.000 20.04851 ? 110 GLN A CA  1 
ATOM   843  C C   . GLN A 1 110 ? 3.68228   17.60503 -23.38152 1.000 21.94434 ? 110 GLN A C   1 
ATOM   844  O O   . GLN A 1 110 ? 2.48890   17.52721 -23.07657 1.000 22.61024 ? 110 GLN A O   1 
ATOM   845  C CB  . GLN A 1 110 ? 4.81146   15.56082 -24.34625 1.000 21.17988 ? 110 GLN A CB  1 
ATOM   846  C CG  . GLN A 1 110 ? 6.01494   14.64351 -24.19515 1.000 29.18200 ? 110 GLN A CG  1 
ATOM   847  C CD  . GLN A 1 110 ? 6.29927   13.77694 -25.40976 1.000 45.18730 ? 110 GLN A CD  1 
ATOM   848  O OE1 . GLN A 1 110 ? 5.43309   13.05466 -25.90345 1.000 37.55055 ? 110 GLN A OE1 1 
ATOM   849  N NE2 . GLN A 1 110 ? 7.53153   13.84786 -25.89785 1.000 59.23343 ? 110 GLN A NE2 1 
ATOM   850  N N   . THR A 1 111 ? 4.20676   18.69269 -23.93019 1.000 21.82089 ? 111 THR A N   1 
ATOM   851  C CA  . THR A 1 111 ? 3.42213   19.88150 -24.20951 1.000 20.11510 ? 111 THR A CA  1 
ATOM   852  C C   . THR A 1 111 ? 3.18003   20.02642 -25.70371 1.000 17.92964 ? 111 THR A C   1 
ATOM   853  O O   . THR A 1 111 ? 3.88010   19.44086 -26.53171 1.000 21.69025 ? 111 THR A O   1 
ATOM   854  C CB  . THR A 1 111 ? 4.12776   21.13476 -23.71561 1.000 18.54841 ? 111 THR A CB  1 
ATOM   855  O OG1 . THR A 1 111 ? 5.44582   21.16025 -24.28929 1.000 20.98715 ? 111 THR A OG1 1 
ATOM   856  C CG2 . THR A 1 111 ? 4.19276   21.14157 -22.14595 1.000 22.29209 ? 111 THR A CG2 1 
ATOM   857  N N   . PHE A 1 112 ? 2.19643   20.86492 -26.02280 1.000 18.70805 ? 112 PHE A N   1 
ATOM   858  C CA  . PHE A 1 112 ? 1.87687   21.16359 -27.41081 1.000 19.80131 ? 112 PHE A CA  1 
ATOM   859  C C   . PHE A 1 112 ? 1.01700   22.41833 -27.45292 1.000 15.46172 ? 112 PHE A C   1 
ATOM   860  O O   . PHE A 1 112 ? 0.42407   22.81612 -26.45263 1.000 20.49305 ? 112 PHE A O   1 
ATOM   861  C CB  . PHE A 1 112 ? 1.17121   19.98401 -28.12192 1.000 18.08640 ? 112 PHE A CB  1 
ATOM   862  C CG  . PHE A 1 112 ? -0.11537  19.49774 -27.44335 1.000 20.55068 ? 112 PHE A CG  1 
ATOM   863  C CD1 . PHE A 1 112 ? -0.07695  18.51966 -26.45778 1.000 21.47812 ? 112 PHE A CD1 1 
ATOM   864  C CD2 . PHE A 1 112 ? -1.34016  20.02708 -27.80184 1.000 17.92326 ? 112 PHE A CD2 1 
ATOM   865  C CE1 . PHE A 1 112 ? -1.26631  18.06593 -25.85749 1.000 22.35393 ? 112 PHE A CE1 1 
ATOM   866  C CE2 . PHE A 1 112 ? -2.52414  19.58038 -27.23731 1.000 25.46499 ? 112 PHE A CE2 1 
ATOM   867  C CZ  . PHE A 1 112 ? -2.49005  18.58463 -26.25565 1.000 23.59031 ? 112 PHE A CZ  1 
ATOM   868  N N   . SER A 1 113 ? 0.94964   23.03808 -28.63749 1.000 15.95450 ? 113 SER A N   1 
ATOM   869  C CA  . SER A 1 113 ? 0.08058   24.19054 -28.83213 1.000 19.35400 ? 113 SER A CA  1 
ATOM   870  C C   . SER A 1 113 ? -1.25534  23.73367 -29.39293 1.000 21.05239 ? 113 SER A C   1 
ATOM   871  O O   . SER A 1 113 ? -1.32973  22.77974 -30.17225 1.000 18.46189 ? 113 SER A O   1 
ATOM   872  C CB  . SER A 1 113 ? 0.71916   25.20420 -29.79251 1.000 19.55664 ? 113 SER A CB  1 
ATOM   873  O OG  . SER A 1 113 ? 1.95081   25.68668 -29.26100 1.000 19.85136 ? 113 SER A OG  1 
ATOM   874  N N   . VAL A 1 114 ? -2.30982  24.43448 -28.99733 1.000 17.30431 ? 114 VAL A N   1 
ATOM   875  C CA  . VAL A 1 114 ? -3.65171  24.20673 -29.52336 1.000 15.72682 ? 114 VAL A CA  1 
ATOM   876  C C   . VAL A 1 114 ? -4.06601  25.43064 -30.31294 1.000 15.84706 ? 114 VAL A C   1 
ATOM   877  O O   . VAL A 1 114 ? -3.96642  26.55689 -29.81073 1.000 18.57516 ? 114 VAL A O   1 
ATOM   878  C CB  . VAL A 1 114 ? -4.64833  23.95551 -28.37721 1.000 19.75948 ? 114 VAL A CB  1 
ATOM   879  C CG1 . VAL A 1 114 ? -6.07623  23.92487 -28.90392 1.000 18.94326 ? 114 VAL A CG1 1 
ATOM   880  C CG2 . VAL A 1 114 ? -4.29836  22.66005 -27.65012 1.000 21.78774 ? 114 VAL A CG2 1 
ATOM   881  N N   . LEU A 1 115 ? -4.61832  25.21275 -31.51458 1.000 16.52038 ? 115 LEU A N   1 
ATOM   882  C CA  . LEU A 1 115 ? -5.23427  26.28728 -32.27898 1.000 20.22147 ? 115 LEU A CA  1 
ATOM   883  C C   . LEU A 1 115 ? -6.73475  26.06198 -32.15870 1.000 17.71413 ? 115 LEU A C   1 
ATOM   884  O O   . LEU A 1 115 ? -7.30401  25.18912 -32.82300 1.000 17.98313 ? 115 LEU A O   1 
ATOM   885  C CB  . LEU A 1 115 ? -4.75567  26.30657 -33.73855 1.000 17.48519 ? 115 LEU A CB  1 
ATOM   886  C CG  . LEU A 1 115 ? -5.42056  27.39955 -34.57634 1.000 20.64552 ? 115 LEU A CG  1 
ATOM   887  C CD1 . LEU A 1 115 ? -4.90018  28.72325 -34.14747 1.000 22.26876 ? 115 LEU A CD1 1 
ATOM   888  C CD2 . LEU A 1 115 ? -5.11134  27.17115 -36.07999 1.000 21.16804 ? 115 LEU A CD2 1 
ATOM   889  N N   . ALA A 1 116 ? -7.36816  26.80050 -31.26157 1.000 18.08234 ? 116 ALA A N   1 
ATOM   890  C CA  . ALA A 1 116 ? -8.80505  26.64978 -31.05948 1.000 18.14452 ? 116 ALA A CA  1 
ATOM   891  C C   . ALA A 1 116 ? -9.57172  27.30931 -32.19570 1.000 21.20612 ? 116 ALA A C   1 
ATOM   892  O O   . ALA A 1 116 ? -9.36511  28.49031 -32.48749 1.000 23.59761 ? 116 ALA A O   1 
ATOM   893  C CB  . ALA A 1 116 ? -9.22508  27.26742 -29.72261 1.000 20.65502 ? 116 ALA A CB  1 
ATOM   894  N N   . CYS A 1 117 ? -10.48627 26.55506 -32.80689 1.000 18.38503 ? 117 CYS A N   1 
ATOM   895  C CA  . CYS A 1 117 ? -11.20963 26.97660 -33.98920 1.000 18.64052 ? 117 CYS A CA  1 
ATOM   896  C C   . CYS A 1 117 ? -12.70772 26.77062 -33.81527 1.000 17.75780 ? 117 CYS A C   1 
ATOM   897  O O   . CYS A 1 117 ? -13.14383 25.88630 -33.07183 1.000 20.50003 ? 117 CYS A O   1 
ATOM   898  C CB  . CYS A 1 117 ? -10.73174 26.17729 -35.19720 1.000 20.05844 ? 117 CYS A CB  1 
ATOM   899  S SG  . CYS A 1 117 ? -9.02518  26.52621 -35.64637 1.000 24.90420 ? 117 CYS A SG  1 
ATOM   900  N N   . TYR A 1 118 ? -13.49247 27.61574 -34.50476 1.000 18.29165 ? 118 TYR A N   1 
ATOM   901  C CA  . TYR A 1 118 ? -14.93961 27.46911 -34.61223 1.000 19.57980 ? 118 TYR A CA  1 
ATOM   902  C C   . TYR A 1 118 ? -15.32677 27.70555 -36.05886 1.000 21.26404 ? 118 TYR A C   1 
ATOM   903  O O   . TYR A 1 118 ? -14.84059 28.64621 -36.68376 1.000 20.99312 ? 118 TYR A O   1 
ATOM   904  C CB  . TYR A 1 118 ? -15.68843 28.44645 -33.67520 1.000 20.42666 ? 118 TYR A CB  1 
ATOM   905  C CG  . TYR A 1 118 ? -15.29527 28.15766 -32.24142 1.000 18.52942 ? 118 TYR A CG  1 
ATOM   906  C CD1 . TYR A 1 118 ? -14.17158 28.76680 -31.69537 1.000 23.31919 ? 118 TYR A CD1 1 
ATOM   907  C CD2 . TYR A 1 118 ? -15.98150 27.20981 -31.48636 1.000 22.83395 ? 118 TYR A CD2 1 
ATOM   908  C CE1 . TYR A 1 118 ? -13.75812 28.44840 -30.40468 1.000 21.97609 ? 118 TYR A CE1 1 
ATOM   909  C CE2 . TYR A 1 118 ? -15.58247 26.90669 -30.17126 1.000 21.05379 ? 118 TYR A CE2 1 
ATOM   910  C CZ  . TYR A 1 118 ? -14.46437 27.53285 -29.67685 1.000 23.62676 ? 118 TYR A CZ  1 
ATOM   911  O OH  . TYR A 1 118 ? -13.99595 27.24622 -28.44192 1.000 21.80035 ? 118 TYR A OH  1 
ATOM   912  N N   . ASN A 1 119 ? -16.16971 26.83363 -36.59953 1.000 23.30219 ? 119 ASN A N   1 
ATOM   913  C CA  . ASN A 1 119 ? -16.63173 27.00547 -37.98026 1.000 25.51247 ? 119 ASN A CA  1 
ATOM   914  C C   . ASN A 1 119 ? -15.46936 27.06449 -38.96719 1.000 22.88220 ? 119 ASN A C   1 
ATOM   915  O O   . ASN A 1 119 ? -15.54144 27.75724 -39.98609 1.000 24.17638 ? 119 ASN A O   1 
ATOM   916  C CB  . ASN A 1 119 ? -17.48033 28.27458 -38.13840 1.000 26.28409 ? 119 ASN A CB  1 
ATOM   917  C CG  . ASN A 1 119 ? -18.68206 28.26699 -37.25668 1.000 32.64184 ? 119 ASN A CG  1 
ATOM   918  O OD1 . ASN A 1 119 ? -18.90470 29.19842 -36.49862 1.000 42.16708 ? 119 ASN A OD1 1 
ATOM   919  N ND2 . ASN A 1 119 ? -19.43993 27.19177 -37.30688 1.000 35.43526 ? 119 ASN A ND2 1 
ATOM   920  N N   . GLY A 1 120 ? -14.37400 26.37248 -38.66143 1.000 22.60493 ? 120 GLY A N   1 
ATOM   921  C CA  . GLY A 1 120 ? -13.24303 26.35986 -39.56426 1.000 23.38627 ? 120 GLY A CA  1 
ATOM   922  C C   . GLY A 1 120 ? -12.33298 27.56409 -39.47198 1.000 25.46202 ? 120 GLY A C   1 
ATOM   923  O O   . GLY A 1 120 ? -11.39048 27.65971 -40.25262 1.000 26.43137 ? 120 GLY A O   1 
ATOM   924  N N   . SER A 1 121 ? -12.59055 28.48884 -38.54682 1.000 24.34019 ? 121 SER A N   1 
ATOM   925  C CA  . SER A 1 121 ? -11.81823 29.71107 -38.38906 1.000 18.07238 ? 121 SER A CA  1 
ATOM   926  C C   . SER A 1 121 ? -11.12884 29.73608 -37.03444 1.000 18.39892 ? 121 SER A C   1 
ATOM   927  O O   . SER A 1 121 ? -11.72573 29.36391 -36.02180 1.000 24.52982 ? 121 SER A O   1 
ATOM   928  C CB  . SER A 1 121 ? -12.70339 30.96349 -38.49086 1.000 26.16636 ? 121 SER A CB  1 
ATOM   929  O OG  . SER A 1 121 ? -13.25910 31.07193 -39.79100 1.000 34.26191 ? 121 SER A OG  1 
ATOM   930  N N   . PRO A 1 122 ? -9.90195  30.22307 -36.98212 1.000 25.67203 ? 122 PRO A N   1 
ATOM   931  C CA  . PRO A 1 122 ? -9.14821  30.20588 -35.72258 1.000 25.09047 ? 122 PRO A CA  1 
ATOM   932  C C   . PRO A 1 122 ? -9.61815  31.30122 -34.77851 1.000 31.35484 ? 122 PRO A C   1 
ATOM   933  O O   . PRO A 1 122 ? -9.89212  32.43066 -35.18360 1.000 31.37275 ? 122 PRO A O   1 
ATOM   934  C CB  . PRO A 1 122 ? -7.71346  30.44550 -36.18739 1.000 31.89651 ? 122 PRO A CB  1 
ATOM   935  C CG  . PRO A 1 122 ? -7.89663  31.36149 -37.35428 1.000 34.28855 ? 122 PRO A CG  1 
ATOM   936  C CD  . PRO A 1 122 ? -9.15608  30.86708 -38.06614 1.000 30.02171 ? 122 PRO A CD  1 
ATOM   937  N N   . SER A 1 123 ? -9.71321  30.95007 -33.50341 1.000 24.64560 ? 123 SER A N   1 
ATOM   938  C CA  . SER A 1 123 ? -10.06151 31.87111 -32.42938 1.000 26.55623 ? 123 SER A CA  1 
ATOM   939  C C   . SER A 1 123 ? -8.82730  32.28968 -31.62381 1.000 21.97086 ? 123 SER A C   1 
ATOM   940  O O   . SER A 1 123 ? -8.70458  33.45558 -31.23923 1.000 25.91584 ? 123 SER A O   1 
ATOM   941  C CB  . SER A 1 123 ? -11.11850 31.22736 -31.51549 1.000 30.43674 ? 123 SER A CB  1 
ATOM   942  O OG  . SER A 1 123 ? -11.49295 32.05858 -30.41645 1.000 39.20146 ? 123 SER A OG  1 
ATOM   943  N N   . GLY A 1 124 ? -7.89222  31.38179 -31.37987 1.000 21.22978 ? 124 GLY A N   1 
ATOM   944  C CA  . GLY A 1 124 ? -6.71688  31.74111 -30.59686 1.000 19.49962 ? 124 GLY A CA  1 
ATOM   945  C C   . GLY A 1 124 ? -5.82076  30.53709 -30.46264 1.000 20.36858 ? 124 GLY A C   1 
ATOM   946  O O   . GLY A 1 124 ? -6.15565  29.42087 -30.88169 1.000 19.81396 ? 124 GLY A O   1 
ATOM   947  N N   . VAL A 1 125 ? -4.65812  30.76677 -29.87115 1.000 17.96129 ? 125 VAL A N   1 
ATOM   948  C CA  . VAL A 1 125 ? -3.69254  29.69743 -29.74722 1.000 15.87806 ? 125 VAL A CA  1 
ATOM   949  C C   . VAL A 1 125 ? -3.15323  29.72575 -28.32287 1.000 18.66364 ? 125 VAL A C   1 
ATOM   950  O O   . VAL A 1 125 ? -2.92677  30.80433 -27.74352 1.000 19.96031 ? 125 VAL A O   1 
ATOM   951  C CB  . VAL A 1 125 ? -2.56235  29.84692 -30.80319 1.000 24.05818 ? 125 VAL A CB  1 
ATOM   952  C CG1 . VAL A 1 125 ? -1.91535  31.20511 -30.72571 1.000 29.60033 ? 125 VAL A CG1 1 
ATOM   953  C CG2 . VAL A 1 125 ? -1.51891  28.73465 -30.69012 1.000 19.89375 ? 125 VAL A CG2 1 
ATOM   954  N N   . TYR A 1 126 ? -2.99857  28.54163 -27.73239 1.000 18.16348 ? 126 TYR A N   1 
ATOM   955  C CA  . TYR A 1 126 ? -2.41009  28.49268 -26.39984 1.000 19.83335 ? 126 TYR A CA  1 
ATOM   956  C C   . TYR A 1 126 ? -1.65069  27.19211 -26.25021 1.000 21.25422 ? 126 TYR A C   1 
ATOM   957  O O   . TYR A 1 126 ? -1.81668  26.24689 -27.01786 1.000 20.70416 ? 126 TYR A O   1 
ATOM   958  C CB  . TYR A 1 126 ? -3.49545  28.63937 -25.30172 1.000 21.55630 ? 126 TYR A CB  1 
ATOM   959  C CG  . TYR A 1 126 ? -4.64048  27.67453 -25.44414 1.000 23.10619 ? 126 TYR A CG  1 
ATOM   960  C CD1 . TYR A 1 126 ? -4.57928  26.41331 -24.86795 1.000 21.73631 ? 126 TYR A CD1 1 
ATOM   961  C CD2 . TYR A 1 126 ? -5.78632  28.02642 -26.14889 1.000 21.72868 ? 126 TYR A CD2 1 
ATOM   962  C CE1 . TYR A 1 126 ? -5.64698  25.51607 -24.99487 1.000 27.73567 ? 126 TYR A CE1 1 
ATOM   963  C CE2 . TYR A 1 126 ? -6.86012  27.13689 -26.27314 1.000 25.40235 ? 126 TYR A CE2 1 
ATOM   964  C CZ  . TYR A 1 126 ? -6.76440  25.88909 -25.70254 1.000 28.13131 ? 126 TYR A CZ  1 
ATOM   965  O OH  . TYR A 1 126 ? -7.81028  25.01600 -25.81594 1.000 29.62977 ? 126 TYR A OH  1 
ATOM   966  N N   . GLN A 1 127 ? -0.81681  27.15638 -25.21930 1.000 20.09825 ? 127 GLN A N   1 
ATOM   967  C CA  . GLN A 1 127 ? 0.06868   26.04324 -24.94458 1.000 21.62004 ? 127 GLN A CA  1 
ATOM   968  C C   . GLN A 1 127 ? -0.55384  25.16783 -23.85774 1.000 21.80602 ? 127 GLN A C   1 
ATOM   969  O O   . GLN A 1 127 ? -1.10325  25.69210 -22.87419 1.000 25.09151 ? 127 GLN A O   1 
ATOM   970  C CB  . GLN A 1 127 ? 1.42408   26.62017 -24.49549 1.000 22.56141 ? 127 GLN A CB  1 
ATOM   971  C CG  . GLN A 1 127 ? 2.47862   25.65842 -24.29859 1.000 29.40017 ? 127 GLN A CG  1 
ATOM   972  C CD  . GLN A 1 127 ? 3.01755   25.11793 -25.58517 1.000 28.09500 ? 127 GLN A CD  1 
ATOM   973  O OE1 . GLN A 1 127 ? 2.52590   25.42983 -26.70412 1.000 24.31331 ? 127 GLN A OE1 1 
ATOM   974  N NE2 . GLN A 1 127 ? 4.05084   24.30511 -25.45867 1.000 26.73865 ? 127 GLN A NE2 1 
ATOM   975  N N   . CYS A 1 128 ? -0.45246  23.84136 -24.02749 1.000 19.33214 ? 128 CYS A N   1 
ATOM   976  C CA  . CYS A 1 128 ? -1.07257  22.83891 -23.14142 1.000 23.39505 ? 128 CYS A CA  1 
ATOM   977  C C   . CYS A 1 128 ? -0.07330  21.74751 -22.81167 1.000 21.82550 ? 128 CYS A C   1 
ATOM   978  O O   . CYS A 1 128 ? 0.91960   21.56941 -23.51411 1.000 24.51201 ? 128 CYS A O   1 
ATOM   979  C CB  . CYS A 1 128 ? -2.28305  22.13835 -23.83129 1.000 30.23053 ? 128 CYS A CB  1 
ATOM   980  S SG  . CYS A 1 128 ? -3.71810  23.10731 -23.74748 1.000 42.90334 ? 128 CYS A SG  1 
ATOM   981  N N   . ALA A 1 129 ? -0.37233  20.95987 -21.77577 1.000 22.83804 ? 129 ALA A N   1 
ATOM   982  C CA  . ALA A 1 129 ? 0.35374   19.71752 -21.49849 1.000 20.43583 ? 129 ALA A CA  1 
ATOM   983  C C   . ALA A 1 129 ? -0.62995  18.55510 -21.52956 1.000 20.65797 ? 129 ALA A C   1 
ATOM   984  O O   . ALA A 1 129 ? -1.77187  18.68861 -21.07468 1.000 24.46952 ? 129 ALA A O   1 
ATOM   985  C CB  . ALA A 1 129 ? 1.06841   19.74876 -20.12887 1.000 25.46607 ? 129 ALA A CB  1 
ATOM   986  N N   . MET A 1 130 ? -0.20200  17.41094 -22.06767 1.000 21.37514 ? 130 MET A N   1 
ATOM   987  C CA  . MET A 1 130 ? -0.96004  16.17941 -21.85701 1.000 21.76116 ? 130 MET A CA  1 
ATOM   988  C C   . MET A 1 130 ? -0.76441  15.78527 -20.40043 1.000 22.11158 ? 130 MET A C   1 
ATOM   989  O O   . MET A 1 130 ? 0.36033   15.52463 -19.97831 1.000 24.61186 ? 130 MET A O   1 
ATOM   990  C CB  . MET A 1 130 ? -0.50104  15.06856 -22.79693 1.000 23.91836 ? 130 MET A CB  1 
ATOM   991  C CG  . MET A 1 130 ? -1.24081  13.72948 -22.61067 1.000 22.24685 ? 130 MET A CG  1 
ATOM   992  S SD  . MET A 1 130 ? -2.98162  13.88704 -22.92974 1.000 26.36369 ? 130 MET A SD  1 
ATOM   993  C CE  . MET A 1 130 ? -2.92983  14.34787 -24.67942 1.000 21.68679 ? 130 MET A CE  1 
ATOM   994  N N   . ARG A 1 131 ? -1.83592  15.81750 -19.61765 1.000 19.91495 ? 131 ARG A N   1 
ATOM   995  C CA  . ARG A 1 131 ? -1.71553  15.55178 -18.19141 1.000 19.45482 ? 131 ARG A CA  1 
ATOM   996  C C   . ARG A 1 131 ? -1.43897  14.07086 -17.97925 1.000 27.14143 ? 131 ARG A C   1 
ATOM   997  O O   . ARG A 1 131 ? -1.76254  13.23924 -18.83539 1.000 22.56369 ? 131 ARG A O   1 
ATOM   998  C CB  . ARG A 1 131 ? -2.97820  15.94370 -17.43651 1.000 19.89456 ? 131 ARG A CB  1 
ATOM   999  C CG  . ARG A 1 131 ? -3.43203  17.41793 -17.56757 1.000 24.15349 ? 131 ARG A CG  1 
ATOM   1000 C CD  . ARG A 1 131 ? -2.36513  18.42148 -17.06468 1.000 20.74487 ? 131 ARG A CD  1 
ATOM   1001 N NE  . ARG A 1 131 ? -1.82191  18.07731 -15.75026 1.000 22.82490 ? 131 ARG A NE  1 
ATOM   1002 C CZ  . ARG A 1 131 ? -0.73936  18.65270 -15.23365 1.000 25.38573 ? 131 ARG A CZ  1 
ATOM   1003 N NH1 . ARG A 1 131 ? -0.15251  19.67901 -15.82745 1.000 20.90469 ? 131 ARG A NH1 1 
ATOM   1004 N NH2 . ARG A 1 131 ? -0.25119  18.20862 -14.08025 1.000 22.26753 ? 131 ARG A NH2 1 
ATOM   1005 N N   . PRO A 1 132 ? -0.87234  13.71056 -16.83134 1.000 22.46157 ? 132 PRO A N   1 
ATOM   1006 C CA  . PRO A 1 132 ? -0.70491  12.28822 -16.51455 1.000 23.72224 ? 132 PRO A CA  1 
ATOM   1007 C C   . PRO A 1 132 ? -2.00501  11.49287 -16.50563 1.000 29.65805 ? 132 PRO A C   1 
ATOM   1008 O O   . PRO A 1 132 ? -1.94671  10.27148 -16.70492 1.000 25.16678 ? 132 PRO A O   1 
ATOM   1009 C CB  . PRO A 1 132 ? -0.03914  12.32195 -15.13371 1.000 27.36092 ? 132 PRO A CB  1 
ATOM   1010 C CG  . PRO A 1 132 ? 0.74433   13.62599 -15.14446 1.000 22.40492 ? 132 PRO A CG  1 
ATOM   1011 C CD  . PRO A 1 132 ? -0.22486  14.57640 -15.82179 1.000 23.76390 ? 132 PRO A CD  1 
ATOM   1012 N N   . ASN A 1 133 ? -3.17302  12.12701 -16.34028 1.000 22.89288 ? 133 ASN A N   1 
ATOM   1013 C CA  . ASN A 1 133 ? -4.44370  11.39636 -16.45059 1.000 21.87071 ? 133 ASN A CA  1 
ATOM   1014 C C   . ASN A 1 133 ? -5.06496  11.48176 -17.84370 1.000 23.24453 ? 133 ASN A C   1 
ATOM   1015 O O   . ASN A 1 133 ? -6.25092  11.16814 -17.99298 1.000 23.15949 ? 133 ASN A O   1 
ATOM   1016 C CB  . ASN A 1 133 ? -5.45046  11.87833 -15.40395 1.000 27.17836 ? 133 ASN A CB  1 
ATOM   1017 C CG  . ASN A 1 133 ? -5.85473  13.30462 -15.61154 1.000 30.64512 ? 133 ASN A CG  1 
ATOM   1018 O OD1 . ASN A 1 133 ? -5.35349  13.95967 -16.51500 1.000 23.05928 ? 133 ASN A OD1 1 
ATOM   1019 N ND2 . ASN A 1 133 ? -6.76314  13.80130 -14.78071 1.000 22.48648 ? 133 ASN A ND2 1 
ATOM   1020 N N   . PHE A 1 134 ? -4.28233  11.90075 -18.84483 1.000 23.22743 ? 134 PHE A N   1 
ATOM   1021 C CA  . PHE A 1 134 ? -4.67457  11.92253 -20.25808 1.000 25.81179 ? 134 PHE A CA  1 
ATOM   1022 C C   . PHE A 1 134 ? -5.78400  12.93401 -20.53458 1.000 27.95704 ? 134 PHE A C   1 
ATOM   1023 O O   . PHE A 1 134 ? -6.61032  12.74060 -21.42487 1.000 26.43957 ? 134 PHE A O   1 
ATOM   1024 C CB  . PHE A 1 134 ? -5.05331  10.51416 -20.75147 1.000 24.94122 ? 134 PHE A CB  1 
ATOM   1025 C CG  . PHE A 1 134 ? -3.89823  9.53979  -20.68190 1.000 24.25114 ? 134 PHE A CG  1 
ATOM   1026 C CD1 . PHE A 1 134 ? -2.88989  9.56783  -21.63000 1.000 31.06934 ? 134 PHE A CD1 1 
ATOM   1027 C CD2 . PHE A 1 134 ? -3.81227  8.62031  -19.64709 1.000 32.64493 ? 134 PHE A CD2 1 
ATOM   1028 C CE1 . PHE A 1 134 ? -1.80922  8.66802  -21.55920 1.000 35.86723 ? 134 PHE A CE1 1 
ATOM   1029 C CE2 . PHE A 1 134 ? -2.73471  7.74145  -19.56474 1.000 30.67609 ? 134 PHE A CE2 1 
ATOM   1030 C CZ  . PHE A 1 134 ? -1.73356  7.77091  -20.52660 1.000 33.81632 ? 134 PHE A CZ  1 
ATOM   1031 N N   . THR A 1 135 ? -5.83333  14.01589 -19.76221 1.000 22.00339 ? 135 THR A N   1 
ATOM   1032 C CA  . THR A 1 135 ? -6.69135  15.15192 -20.06033 1.000 22.81183 ? 135 THR A CA  1 
ATOM   1033 C C   . THR A 1 135 ? -5.79322  16.31779 -20.42184 1.000 20.79359 ? 135 THR A C   1 
ATOM   1034 O O   . THR A 1 135 ? -4.58159  16.27284 -20.19380 1.000 23.93454 ? 135 THR A O   1 
ATOM   1035 C CB  . THR A 1 135 ? -7.58639  15.52102 -18.86915 1.000 25.39364 ? 135 THR A CB  1 
ATOM   1036 O OG1 . THR A 1 135 ? -6.76787  15.93234 -17.76415 1.000 26.39460 ? 135 THR A OG1 1 
ATOM   1037 C CG2 . THR A 1 135 ? -8.43304  14.33923 -18.43825 1.000 23.93126 ? 135 THR A CG2 1 
ATOM   1038 N N   . ILE A 1 136 ? -6.38545  17.36325 -21.00232 1.000 22.70790 ? 136 ILE A N   1 
ATOM   1039 C CA  . ILE A 1 136 ? -5.68630  18.63146 -21.13439 1.000 18.74252 ? 136 ILE A CA  1 
ATOM   1040 C C   . ILE A 1 136 ? -6.53622  19.72208 -20.51058 1.000 18.10835 ? 136 ILE A C   1 
ATOM   1041 O O   . ILE A 1 136 ? -7.77222  19.63241 -20.45491 1.000 22.04232 ? 136 ILE A O   1 
ATOM   1042 C CB  . ILE A 1 136 ? -5.30108  19.00026 -22.58887 1.000 22.70443 ? 136 ILE A CB  1 
ATOM   1043 C CG1 . ILE A 1 136 ? -6.49135  19.43707 -23.43456 1.000 22.26963 ? 136 ILE A CG1 1 
ATOM   1044 C CG2 . ILE A 1 136 ? -4.47665  17.86190 -23.23465 1.000 23.27518 ? 136 ILE A CG2 1 
ATOM   1045 C CD1 . ILE A 1 136 ? -6.04116  19.66080 -24.91008 1.000 19.63717 ? 136 ILE A CD1 1 
ATOM   1046 N N   . LYS A 1 137 ? -5.86134  20.71740 -19.96413 1.000 21.56386 ? 137 LYS A N   1 
ATOM   1047 C CA  . LYS A 1 137 ? -6.53323  21.85930 -19.35296 1.000 20.27441 ? 137 LYS A CA  1 
ATOM   1048 C C   . LYS A 1 137 ? -6.63986  22.90385 -20.44935 1.000 23.52564 ? 137 LYS A C   1 
ATOM   1049 O O   . LYS A 1 137 ? -5.75979  23.75863 -20.60982 1.000 28.73330 ? 137 LYS A O   1 
ATOM   1050 C CB  . LYS A 1 137 ? -5.74486  22.35190 -18.13973 1.000 20.16094 ? 137 LYS A CB  1 
ATOM   1051 C CG  . LYS A 1 137 ? -5.70056  21.34815 -17.00985 1.000 26.77889 ? 137 LYS A CG  1 
ATOM   1052 C CD  . LYS A 1 137 ? -4.75706  21.85257 -15.89476 1.000 38.30952 ? 137 LYS A CD  1 
ATOM   1053 C CE  . LYS A 1 137 ? -4.72621  20.91799 -14.68829 1.000 46.34399 ? 137 LYS A CE  1 
ATOM   1054 N NZ  . LYS A 1 137 ? -3.52743  21.20540 -13.82471 1.000 48.17420 ? 137 LYS A NZ  1 
ATOM   1055 N N   . GLY A 1 138 ? -7.69582  22.79111 -21.26302 1.000 17.70476 ? 138 GLY A N   1 
ATOM   1056 C CA  . GLY A 1 138 ? -7.89203  23.67352 -22.38398 1.000 20.97405 ? 138 GLY A CA  1 
ATOM   1057 C C   . GLY A 1 138 ? -8.89805  24.77541 -22.13242 1.000 21.88928 ? 138 GLY A C   1 
ATOM   1058 O O   . GLY A 1 138 ? -9.29339  25.08865 -21.00445 1.000 21.45563 ? 138 GLY A O   1 
ATOM   1059 N N   . SER A 1 139 ? -9.30645  25.38175 -23.24358 1.000 18.69277 ? 139 SER A N   1 
ATOM   1060 C CA  . SER A 1 139 ? -10.36422 26.38382 -23.27561 1.000 19.22685 ? 139 SER A CA  1 
ATOM   1061 C C   . SER A 1 139 ? -11.10409 26.10758 -24.57434 1.000 20.06867 ? 139 SER A C   1 
ATOM   1062 O O   . SER A 1 139 ? -10.61195 26.43709 -25.66595 1.000 21.52271 ? 139 SER A O   1 
ATOM   1063 C CB  . SER A 1 139 ? -9.79525  27.79395 -23.25089 1.000 22.99791 ? 139 SER A CB  1 
ATOM   1064 O OG  . SER A 1 139 ? -10.85185 28.73789 -23.37079 1.000 26.15898 ? 139 SER A OG  1 
ATOM   1065 N N   . PHE A 1 140 ? -12.26490 25.47852 -24.46098 1.000 20.99355 ? 140 PHE A N   1 
ATOM   1066 C CA  . PHE A 1 140 ? -12.97859 24.98504 -25.63193 1.000 16.58031 ? 140 PHE A CA  1 
ATOM   1067 C C   . PHE A 1 140 ? -14.46537 25.11715 -25.35831 1.000 20.17479 ? 140 PHE A C   1 
ATOM   1068 O O   . PHE A 1 140 ? -14.93051 24.83345 -24.24908 1.000 21.94119 ? 140 PHE A O   1 
ATOM   1069 C CB  . PHE A 1 140 ? -12.69928 23.49887 -25.93083 1.000 18.56986 ? 140 PHE A CB  1 
ATOM   1070 C CG  . PHE A 1 140 ? -11.30883 23.16742 -26.41970 1.000 20.54767 ? 140 PHE A CG  1 
ATOM   1071 C CD1 . PHE A 1 140 ? -10.90466 23.47480 -27.70616 1.000 25.18568 ? 140 PHE A CD1 1 
ATOM   1072 C CD2 . PHE A 1 140 ? -10.47576 22.40864 -25.63122 1.000 25.34542 ? 140 PHE A CD2 1 
ATOM   1073 C CE1 . PHE A 1 140 ? -9.62811  23.09600 -28.15579 1.000 22.53231 ? 140 PHE A CE1 1 
ATOM   1074 C CE2 . PHE A 1 140 ? -9.21910  22.01973 -26.07378 1.000 29.03285 ? 140 PHE A CE2 1 
ATOM   1075 C CZ  . PHE A 1 140 ? -8.80617  22.34974 -27.32277 1.000 23.18526 ? 140 PHE A CZ  1 
ATOM   1076 N N   . LEU A 1 141 ? -15.20070 25.50496 -26.38756 1.000 21.12172 ? 141 LEU A N   1 
ATOM   1077 C CA  . LEU A 1 141 ? -16.63715 25.67974 -26.32630 1.000 22.19327 ? 141 LEU A CA  1 
ATOM   1078 C C   . LEU A 1 141 ? -17.29454 24.73339 -27.30615 1.000 21.00161 ? 141 LEU A C   1 
ATOM   1079 O O   . LEU A 1 141 ? -16.62990 24.08857 -28.12164 1.000 20.84113 ? 141 LEU A O   1 
ATOM   1080 C CB  . LEU A 1 141 ? -17.01735 27.11620 -26.66737 1.000 19.25689 ? 141 LEU A CB  1 
ATOM   1081 C CG  . LEU A 1 141 ? -16.33569 28.18769 -25.84245 1.000 21.65305 ? 141 LEU A CG  1 
ATOM   1082 C CD1 . LEU A 1 141 ? -16.53637 29.51739 -26.51645 1.000 26.51707 ? 141 LEU A CD1 1 
ATOM   1083 C CD2 . LEU A 1 141 ? -16.88470 28.19772 -24.43664 1.000 23.26999 ? 141 LEU A CD2 1 
ATOM   1084 N N   . ASN A 1 142 ? -18.62887 24.66977 -27.24982 1.000 23.30842 ? 142 ASN A N   1 
ATOM   1085 C CA  . ASN A 1 142 ? -19.34613 23.96162 -28.30381 1.000 21.65710 ? 142 ASN A CA  1 
ATOM   1086 C C   . ASN A 1 142 ? -18.92846 24.46668 -29.68564 1.000 20.36237 ? 142 ASN A C   1 
ATOM   1087 O O   . ASN A 1 142 ? -18.85953 25.67069 -29.94311 1.000 23.27838 ? 142 ASN A O   1 
ATOM   1088 C CB  . ASN A 1 142 ? -20.85513 24.11141 -28.11991 1.000 24.49901 ? 142 ASN A CB  1 
ATOM   1089 C CG  . ASN A 1 142 ? -21.61343 23.18146 -29.03391 1.000 36.32749 ? 142 ASN A CG  1 
ATOM   1090 O OD1 . ASN A 1 142 ? -21.31963 21.98550 -29.08349 1.000 39.37064 ? 142 ASN A OD1 1 
ATOM   1091 N ND2 . ASN A 1 142 ? -22.55923 23.72303 -29.79244 1.000 51.43194 ? 142 ASN A ND2 1 
ATOM   1092 N N   . GLY A 1 143 ? -18.62579 23.53017 -30.57820 1.000 19.82208 ? 143 GLY A N   1 
ATOM   1093 C CA  . GLY A 1 143 ? -18.14422 23.85546 -31.89730 1.000 18.92841 ? 143 GLY A CA  1 
ATOM   1094 C C   . GLY A 1 143 ? -16.63504 23.79401 -32.07138 1.000 18.45980 ? 143 GLY A C   1 
ATOM   1095 O O   . GLY A 1 143 ? -16.15277 23.95607 -33.19948 1.000 19.75801 ? 143 GLY A O   1 
ATOM   1096 N N   . SER A 1 144 ? -15.87967 23.64245 -30.99134 1.000 20.77790 ? 144 SER A N   1 
ATOM   1097 C CA  . SER A 1 144 ? -14.41965 23.56614 -31.07801 1.000 19.42291 ? 144 SER A CA  1 
ATOM   1098 C C   . SER A 1 144 ? -13.89160 22.21334 -31.53072 1.000 20.05329 ? 144 SER A C   1 
ATOM   1099 O O   . SER A 1 144 ? -12.70380 22.12268 -31.84830 1.000 20.59865 ? 144 SER A O   1 
ATOM   1100 C CB  . SER A 1 144 ? -13.81543 23.90003 -29.69447 1.000 16.32978 ? 144 SER A CB  1 
ATOM   1101 O OG  . SER A 1 144 ? -14.24731 22.95173 -28.73536 1.000 22.59264 ? 144 SER A OG  1 
ATOM   1102 N N   . CYS A 1 145 ? -14.71472 21.14880 -31.53261 1.000 19.69383 ? 145 CYS A N   1 
ATOM   1103 C CA  . CYS A 1 145 ? -14.21428 19.82210 -31.89644 1.000 19.21706 ? 145 CYS A CA  1 
ATOM   1104 C C   . CYS A 1 145 ? -13.56375 19.86602 -33.27128 1.000 18.59135 ? 145 CYS A C   1 
ATOM   1105 O O   . CYS A 1 145 ? -14.02752 20.57504 -34.16034 1.000 20.83117 ? 145 CYS A O   1 
ATOM   1106 C CB  . CYS A 1 145 ? -15.35589 18.80177 -31.91321 1.000 31.04999 ? 145 CYS A CB  1 
ATOM   1107 S SG  . CYS A 1 145 ? -16.14800 18.67733 -30.30935 1.000 47.31858 ? 145 CYS A SG  1 
ATOM   1108 N N   . GLY A 1 146 ? -12.47920 19.10225 -33.43390 1.000 20.87262 ? 146 GLY A N   1 
ATOM   1109 C CA  . GLY A 1 146 ? -11.68220 19.14575 -34.64265 1.000 19.61498 ? 146 GLY A CA  1 
ATOM   1110 C C   . GLY A 1 146 ? -10.55638 20.14309 -34.58878 1.000 18.10723 ? 146 GLY A C   1 
ATOM   1111 O O   . GLY A 1 146 ? -9.67287  20.10954 -35.44751 1.000 21.50174 ? 146 GLY A O   1 
ATOM   1112 N N   . SER A 1 147 ? -10.54863 21.02414 -33.58655 1.000 19.88292 ? 147 SER A N   1 
ATOM   1113 C CA  . SER A 1 147 ? -9.36702  21.83224 -33.31230 1.000 17.90679 ? 147 SER A CA  1 
ATOM   1114 C C   . SER A 1 147 ? -8.20892  20.90412 -32.99931 1.000 15.78303 ? 147 SER A C   1 
ATOM   1115 O O   . SER A 1 147 ? -8.39237  19.85004 -32.37648 1.000 18.53219 ? 147 SER A O   1 
ATOM   1116 C CB  . SER A 1 147 ? -9.63564  22.73920 -32.09463 1.000 18.29858 ? 147 SER A CB  1 
ATOM   1117 O OG  . SER A 1 147 ? -10.65842 23.69017 -32.35498 1.000 22.90733 ? 147 SER A OG  1 
ATOM   1118 N N   . VAL A 1 148 ? -6.98993  21.29713 -33.39505 1.000 15.82112 ? 148 VAL A N   1 
ATOM   1119 C CA  . VAL A 1 148 ? -5.85961  20.37502 -33.26366 1.000 15.37249 ? 148 VAL A CA  1 
ATOM   1120 C C   . VAL A 1 148 ? -4.75592  20.94130 -32.36712 1.000 18.66913 ? 148 VAL A C   1 
ATOM   1121 O O   . VAL A 1 148 ? -4.60620  22.15041 -32.16925 1.000 19.07005 ? 148 VAL A O   1 
ATOM   1122 C CB  . VAL A 1 148 ? -5.26664  19.92168 -34.63230 1.000 17.82041 ? 148 VAL A CB  1 
ATOM   1123 C CG1 . VAL A 1 148 ? -6.34163  19.21824 -35.49637 1.000 20.38045 ? 148 VAL A CG1 1 
ATOM   1124 C CG2 . VAL A 1 148 ? -4.63044  21.05062 -35.41611 1.000 17.88550 ? 148 VAL A CG2 1 
ATOM   1125 N N   . GLY A 1 149 ? -3.98781  20.01625 -31.80818 1.000 19.91800 ? 149 GLY A N   1 
ATOM   1126 C CA  . GLY A 1 149 ? -2.77224  20.32809 -31.07165 1.000 18.42234 ? 149 GLY A CA  1 
ATOM   1127 C C   . GLY A 1 149 ? -1.55822  19.86454 -31.86244 1.000 20.50303 ? 149 GLY A C   1 
ATOM   1128 O O   . GLY A 1 149 ? -1.63310  18.87651 -32.59327 1.000 17.17406 ? 149 GLY A O   1 
ATOM   1129 N N   . PHE A 1 150 ? -0.42220  20.54156 -31.67841 1.000 18.32253 ? 150 PHE A N   1 
ATOM   1130 C CA  . PHE A 1 150 ? 0.72649   20.30102 -32.56534 1.000 16.37281 ? 150 PHE A CA  1 
ATOM   1131 C C   . PHE A 1 150 ? 2.00435   20.81518 -31.92613 1.000 20.85492 ? 150 PHE A C   1 
ATOM   1132 O O   . PHE A 1 150 ? 1.97070   21.66840 -31.04445 1.000 19.65463 ? 150 PHE A O   1 
ATOM   1133 C CB  . PHE A 1 150 ? 0.54757   21.00178 -33.92875 1.000 18.84631 ? 150 PHE A CB  1 
ATOM   1134 C CG  . PHE A 1 150 ? 0.39357   22.49526 -33.82654 1.000 16.33464 ? 150 PHE A CG  1 
ATOM   1135 C CD1 . PHE A 1 150 ? -0.84926  23.06072 -33.50656 1.000 20.88042 ? 150 PHE A CD1 1 
ATOM   1136 C CD2 . PHE A 1 150 ? 1.46918   23.34067 -34.02840 1.000 20.85271 ? 150 PHE A CD2 1 
ATOM   1137 C CE1 . PHE A 1 150 ? -0.99771  24.45447 -33.37524 1.000 21.32720 ? 150 PHE A CE1 1 
ATOM   1138 C CE2 . PHE A 1 150 ? 1.32891   24.73338 -33.93993 1.000 20.83266 ? 150 PHE A CE2 1 
ATOM   1139 C CZ  . PHE A 1 150 ? 0.11116   25.30134 -33.59361 1.000 24.48528 ? 150 PHE A CZ  1 
ATOM   1140 N N   . ASN A 1 151 ? 3.13311   20.29730 -32.42034 1.000 20.89656 ? 151 ASN A N   1 
ATOM   1141 C CA  . ASN A 1 151 ? 4.45227   20.85843 -32.17942 1.000 19.23273 ? 151 ASN A CA  1 
ATOM   1142 C C   . ASN A 1 151 ? 5.07596   21.18461 -33.52545 1.000 24.13687 ? 151 ASN A C   1 
ATOM   1143 O O   . ASN A 1 151 ? 4.61503   20.72458 -34.57343 1.000 25.05692 ? 151 ASN A O   1 
ATOM   1144 C CB  . ASN A 1 151 ? 5.34174   19.88442 -31.38012 1.000 21.85488 ? 151 ASN A CB  1 
ATOM   1145 C CG  . ASN A 1 151 ? 4.95925   19.82420 -29.93964 1.000 32.47337 ? 151 ASN A CG  1 
ATOM   1146 O OD1 . ASN A 1 151 ? 4.09128   19.05253 -29.56438 1.000 27.72165 ? 151 ASN A OD1 1 
ATOM   1147 N ND2 . ASN A 1 151 ? 5.61061   20.63094 -29.11649 1.000 26.66545 ? 151 ASN A ND2 1 
ATOM   1148 N N   . ILE A 1 152 ? 6.10263   22.01497 -33.52640 1.000 24.77411 ? 152 ILE A N   1 
ATOM   1149 C CA  . ILE A 1 152 ? 6.81430   22.28089 -34.77110 1.000 19.73104 ? 152 ILE A CA  1 
ATOM   1150 C C   . ILE A 1 152 ? 8.28662   22.01905 -34.52626 1.000 26.43668 ? 152 ILE A C   1 
ATOM   1151 O O   . ILE A 1 152 ? 8.81096   22.33174 -33.45775 1.000 29.37886 ? 152 ILE A O   1 
ATOM   1152 C CB  . ILE A 1 152 ? 6.58917   23.70433 -35.28482 1.000 21.40684 ? 152 ILE A CB  1 
ATOM   1153 C CG1 . ILE A 1 152 ? 5.09307   24.00509 -35.38625 1.000 28.06062 ? 152 ILE A CG1 1 
ATOM   1154 C CG2 . ILE A 1 152 ? 7.29366   23.87316 -36.67447 1.000 27.81875 ? 152 ILE A CG2 1 
ATOM   1155 C CD1 . ILE A 1 152 ? 4.80565   25.36747 -35.94025 1.000 34.16125 ? 152 ILE A CD1 1 
ATOM   1156 N N   . ASP A 1 153 ? 8.94458   21.43116 -35.51544 1.000 27.99591 ? 153 ASP A N   1 
ATOM   1157 C CA  . ASP A 1 153 ? 10.38546  21.18041 -35.46945 1.000 34.17882 ? 153 ASP A CA  1 
ATOM   1158 C C   . ASP A 1 153 ? 10.91083  21.70610 -36.80025 1.000 34.63702 ? 153 ASP A C   1 
ATOM   1159 O O   . ASP A 1 153 ? 10.68293  21.08763 -37.84269 1.000 30.81728 ? 153 ASP A O   1 
ATOM   1160 C CB  . ASP A 1 153 ? 10.68068  19.69819 -35.26402 1.000 37.66519 ? 153 ASP A CB  1 
ATOM   1161 C CG  . ASP A 1 153 ? 12.16657  19.37639 -35.33477 1.000 65.80026 ? 153 ASP A CG  1 
ATOM   1162 O OD1 . ASP A 1 153 ? 12.99622  20.28455 -35.10315 1.000 65.12957 ? 153 ASP A OD1 1 
ATOM   1163 O OD2 . ASP A 1 153 ? 12.50687  18.21048 -35.63246 1.000 69.12128 ? 153 ASP A OD2 1 
ATOM   1164 N N   . TYR A 1 154 ? 11.55164  22.87743 -36.76717 1.000 31.19716 ? 154 TYR A N   1 
ATOM   1165 C CA  . TYR A 1 154 ? 12.00085  23.56835 -37.97114 1.000 40.58158 ? 154 TYR A CA  1 
ATOM   1166 C C   . TYR A 1 154 ? 10.84696  23.84644 -38.92853 1.000 35.55332 ? 154 TYR A C   1 
ATOM   1167 O O   . TYR A 1 154 ? 10.10299  24.81391 -38.73136 1.000 37.62946 ? 154 TYR A O   1 
ATOM   1168 C CB  . TYR A 1 154 ? 13.10024  22.77875 -38.68005 1.000 42.77021 ? 154 TYR A CB  1 
ATOM   1169 C CG  . TYR A 1 154 ? 13.59549  23.50559 -39.91217 1.000 63.64496 ? 154 TYR A CG  1 
ATOM   1170 C CD1 . TYR A 1 154 ? 13.81086  24.88199 -39.88476 1.000 64.51024 ? 154 TYR A CD1 1 
ATOM   1171 C CD2 . TYR A 1 154 ? 13.82573  22.82825 -41.10675 1.000 57.36370 ? 154 TYR A CD2 1 
ATOM   1172 C CE1 . TYR A 1 154 ? 14.25071  25.56391 -41.01177 1.000 63.82264 ? 154 TYR A CE1 1 
ATOM   1173 C CE2 . TYR A 1 154 ? 14.26696  23.50135 -42.23313 1.000 64.50881 ? 154 TYR A CE2 1 
ATOM   1174 C CZ  . TYR A 1 154 ? 14.47787  24.86693 -42.18065 1.000 72.53356 ? 154 TYR A CZ  1 
ATOM   1175 O OH  . TYR A 1 154 ? 14.91869  25.53515 -43.30315 1.000 94.58605 ? 154 TYR A OH  1 
ATOM   1176 N N   . ASP A 1 155 ? 10.67669  23.02362 -39.97040 1.000 30.45611 ? 155 ASP A N   1 
ATOM   1177 C CA  . ASP A 1 155 ? 9.59508   23.23813 -40.93152 1.000 30.98604 ? 155 ASP A CA  1 
ATOM   1178 C C   . ASP A 1 155 ? 8.48031   22.20572 -40.82155 1.000 32.60639 ? 155 ASP A C   1 
ATOM   1179 O O   . ASP A 1 155 ? 7.50642   22.28341 -41.57932 1.000 32.07011 ? 155 ASP A O   1 
ATOM   1180 C CB  . ASP A 1 155 ? 10.14488  23.26578 -42.37509 1.000 38.74448 ? 155 ASP A CB  1 
ATOM   1181 C CG  . ASP A 1 155 ? 10.78241  21.94465 -42.80652 1.000 45.08850 ? 155 ASP A CG  1 
ATOM   1182 O OD1 . ASP A 1 155 ? 11.17140  21.12037 -41.95500 1.000 34.74349 ? 155 ASP A OD1 1 
ATOM   1183 O OD2 . ASP A 1 155 ? 10.92549  21.74609 -44.02981 1.000 38.77457 ? 155 ASP A OD2 1 
ATOM   1184 N N   . CYS A 1 156 ? 8.58481   21.26461 -39.88663 1.000 27.25065 ? 156 CYS A N   1 
ATOM   1185 C CA  . CYS A 1 156 ? 7.73960   20.08444 -39.84145 1.000 23.95587 ? 156 CYS A CA  1 
ATOM   1186 C C   . CYS A 1 156 ? 6.74464   20.26040 -38.70438 1.000 25.04724 ? 156 CYS A C   1 
ATOM   1187 O O   . CYS A 1 156 ? 7.15113   20.41684 -37.54445 1.000 25.44073 ? 156 CYS A O   1 
ATOM   1188 C CB  . CYS A 1 156 ? 8.56571   18.82342 -39.61582 1.000 26.78914 ? 156 CYS A CB  1 
ATOM   1189 S SG  . CYS A 1 156 ? 7.60233   17.33650 -39.66568 1.000 30.75537 ? 156 CYS A SG  1 
ATOM   1190 N N   . VAL A 1 157 ? 5.45971   20.22142 -39.03449 1.000 21.33302 ? 157 VAL A N   1 
ATOM   1191 C CA  . VAL A 1 157 ? 4.38454   20.25234 -38.03248 1.000 20.92845 ? 157 VAL A CA  1 
ATOM   1192 C C   . VAL A 1 157 ? 4.06281   18.81510 -37.62578 1.000 19.62884 ? 157 VAL A C   1 
ATOM   1193 O O   . VAL A 1 157 ? 3.63873   18.01115 -38.46149 1.000 22.50811 ? 157 VAL A O   1 
ATOM   1194 C CB  . VAL A 1 157 ? 3.12263   20.95263 -38.58147 1.000 19.62458 ? 157 VAL A CB  1 
ATOM   1195 C CG1 . VAL A 1 157 ? 2.02094   21.04302 -37.47447 1.000 21.52080 ? 157 VAL A CG1 1 
ATOM   1196 C CG2 . VAL A 1 157 ? 3.43527   22.34799 -39.15615 1.000 25.14266 ? 157 VAL A CG2 1 
ATOM   1197 N N   . SER A 1 158 ? 4.25477   18.48312 -36.33953 1.000 20.76190 ? 158 SER A N   1 
ATOM   1198 C CA  . SER A 1 158 ? 3.82616   17.20900 -35.77828 1.000 21.83346 ? 158 SER A CA  1 
ATOM   1199 C C   . SER A 1 158 ? 2.46920   17.40933 -35.11944 1.000 21.16477 ? 158 SER A C   1 
ATOM   1200 O O   . SER A 1 158 ? 2.37601   18.02247 -34.04445 1.000 21.88469 ? 158 SER A O   1 
ATOM   1201 C CB  . SER A 1 158 ? 4.82375   16.67098 -34.75970 1.000 30.68842 ? 158 SER A CB  1 
ATOM   1202 O OG  . SER A 1 158 ? 5.98345   16.20239 -35.41426 1.000 28.56752 ? 158 SER A OG  1 
ATOM   1203 N N   . PHE A 1 159 ? 1.42505   16.88735 -35.74792 1.000 19.30962 ? 159 PHE A N   1 
ATOM   1204 C CA  . PHE A 1 159 ? 0.09163   16.93368 -35.16170 1.000 20.27063 ? 159 PHE A CA  1 
ATOM   1205 C C   . PHE A 1 159 ? -0.06961  15.79980 -34.17081 1.000 20.17821 ? 159 PHE A C   1 
ATOM   1206 O O   . PHE A 1 159 ? 0.14250   14.63489 -34.50934 1.000 22.49644 ? 159 PHE A O   1 
ATOM   1207 C CB  . PHE A 1 159 ? -0.95455  16.79899 -36.26520 1.000 18.24523 ? 159 PHE A CB  1 
ATOM   1208 C CG  . PHE A 1 159 ? -0.97499  17.93125 -37.21599 1.000 18.87117 ? 159 PHE A CG  1 
ATOM   1209 C CD1 . PHE A 1 159 ? -1.59362  19.12972 -36.88147 1.000 16.89442 ? 159 PHE A CD1 1 
ATOM   1210 C CD2 . PHE A 1 159 ? -0.42158  17.78798 -38.50466 1.000 18.71153 ? 159 PHE A CD2 1 
ATOM   1211 C CE1 . PHE A 1 159 ? -1.64197  20.19596 -37.79481 1.000 20.65499 ? 159 PHE A CE1 1 
ATOM   1212 C CE2 . PHE A 1 159 ? -0.45459  18.81503 -39.41116 1.000 16.89605 ? 159 PHE A CE2 1 
ATOM   1213 C CZ  . PHE A 1 159 ? -1.05286  20.02982 -39.08888 1.000 20.51447 ? 159 PHE A CZ  1 
ATOM   1214 N N   . CYS A 1 160 ? -0.46933  16.13747 -32.93402 1.000 19.29985 ? 160 CYS A N   1 
ATOM   1215 C CA  . CYS A 1 160 ? -0.57586  15.15187 -31.87349 1.000 19.94945 ? 160 CYS A CA  1 
ATOM   1216 C C   . CYS A 1 160 ? -1.94950  15.07661 -31.23170 1.000 18.16528 ? 160 CYS A C   1 
ATOM   1217 O O   . CYS A 1 160 ? -2.20071  14.12422 -30.48762 1.000 23.49216 ? 160 CYS A O   1 
ATOM   1218 C CB  . CYS A 1 160 ? 0.44716   15.41871 -30.76881 1.000 21.56899 ? 160 CYS A CB  1 
ATOM   1219 S SG  . CYS A 1 160 ? 0.32438   17.03355 -30.00487 1.000 23.69040 ? 160 CYS A SG  1 
ATOM   1220 N N   . TYR A 1 161 ? -2.85462  16.00874 -31.51772 1.000 17.40043 ? 161 TYR A N   1 
ATOM   1221 C CA  . TYR A 1 161 ? -4.12177  16.01217 -30.77771 1.000 19.91960 ? 161 TYR A CA  1 
ATOM   1222 C C   . TYR A 1 161 ? -5.23144  16.51387 -31.68105 1.000 19.37130 ? 161 TYR A C   1 
ATOM   1223 O O   . TYR A 1 161 ? -5.02378  17.45868 -32.44487 1.000 18.23181 ? 161 TYR A O   1 
ATOM   1224 C CB  . TYR A 1 161 ? -4.01382  16.91576 -29.53528 1.000 20.43410 ? 161 TYR A CB  1 
ATOM   1225 C CG  . TYR A 1 161 ? -5.26653  17.02825 -28.68753 1.000 19.55323 ? 161 TYR A CG  1 
ATOM   1226 C CD1 . TYR A 1 161 ? -5.57263  16.07697 -27.74646 1.000 21.99876 ? 161 TYR A CD1 1 
ATOM   1227 C CD2 . TYR A 1 161 ? -6.11648  18.12293 -28.83479 1.000 16.97413 ? 161 TYR A CD2 1 
ATOM   1228 C CE1 . TYR A 1 161 ? -6.71574  16.20829 -26.94234 1.000 22.06647 ? 161 TYR A CE1 1 
ATOM   1229 C CE2 . TYR A 1 161 ? -7.27500  18.25711 -28.05255 1.000 17.95550 ? 161 TYR A CE2 1 
ATOM   1230 C CZ  . TYR A 1 161 ? -7.55494  17.30108 -27.11966 1.000 22.48575 ? 161 TYR A CZ  1 
ATOM   1231 O OH  . TYR A 1 161 ? -8.69910  17.42309 -26.34891 1.000 20.88376 ? 161 TYR A OH  1 
ATOM   1232 N N   . MET A 1 162 ? -6.40776  15.89020 -31.58438 1.000 17.60137 ? 162 MET A N   1 
ATOM   1233 C CA  . MET A 1 162 ? -7.62428  16.46380 -32.15606 1.000 16.08435 ? 162 MET A CA  1 
ATOM   1234 C C   . MET A 1 162 ? -8.68308  16.50403 -31.05235 1.000 18.93673 ? 162 MET A C   1 
ATOM   1235 O O   . MET A 1 162 ? -8.86286  15.52232 -30.32448 1.000 18.51945 ? 162 MET A O   1 
ATOM   1236 C CB  . MET A 1 162 ? -8.13462  15.67308 -33.37928 1.000 20.34238 ? 162 MET A CB  1 
ATOM   1237 C CG  . MET A 1 162 ? -9.47240  16.25411 -33.88021 1.000 18.83710 ? 162 MET A CG  1 
ATOM   1238 S SD  . MET A 1 162 ? -9.91668  15.63378 -35.51947 1.000 26.01423 ? 162 MET A SD  1 
ATOM   1239 C CE  . MET A 1 162 ? -8.88527  16.66319 -36.54639 1.000 28.63820 ? 162 MET A CE  1 
ATOM   1240 N N   . HIS A 1 163 ? -9.33748  17.64831 -30.89007 1.000 19.06212 ? 163 HIS A N   1 
ATOM   1241 C CA  . HIS A 1 163 ? -10.24935 17.80927 -29.76071 1.000 17.95907 ? 163 HIS A CA  1 
ATOM   1242 C C   . HIS A 1 163 ? -11.59823 17.12567 -30.01061 1.000 17.73119 ? 163 HIS A C   1 
ATOM   1243 O O   . HIS A 1 163 ? -12.18082 17.26539 -31.08383 1.000 22.28629 ? 163 HIS A O   1 
ATOM   1244 C CB  . HIS A 1 163 ? -10.45787 19.29408 -29.48345 1.000 19.23420 ? 163 HIS A CB  1 
ATOM   1245 C CG  . HIS A 1 163 ? -11.31398 19.51304 -28.30077 1.000 19.01540 ? 163 HIS A CG  1 
ATOM   1246 N ND1 . HIS A 1 163 ? -11.03989 18.91663 -27.09598 1.000 18.12504 ? 163 HIS A ND1 1 
ATOM   1247 C CD2 . HIS A 1 163 ? -12.50303 20.14667 -28.15853 1.000 19.68885 ? 163 HIS A CD2 1 
ATOM   1248 C CE1 . HIS A 1 163 ? -12.00295 19.20964 -26.23349 1.000 19.93387 ? 163 HIS A CE1 1 
ATOM   1249 N NE2 . HIS A 1 163 ? -12.90480 19.95111 -26.85705 1.000 19.07137 ? 163 HIS A NE2 1 
ATOM   1250 N N   . HIS A 1 164 ? -12.10178 16.40005 -28.99360 1.000 19.70007 ? 164 HIS A N   1 
ATOM   1251 C CA  . HIS A 1 164 ? -13.42348 15.77304 -29.08459 1.000 18.36314 ? 164 HIS A CA  1 
ATOM   1252 C C   . HIS A 1 164 ? -14.39872 16.14494 -27.97397 1.000 21.64332 ? 164 HIS A C   1 
ATOM   1253 O O   . HIS A 1 164 ? -15.56444 16.36984 -28.29008 1.000 20.89840 ? 164 HIS A O   1 
ATOM   1254 C CB  . HIS A 1 164 ? -13.34008 14.24864 -29.11229 1.000 19.62389 ? 164 HIS A CB  1 
ATOM   1255 C CG  . HIS A 1 164 ? -12.69194 13.71695 -30.36153 1.000 21.86851 ? 164 HIS A CG  1 
ATOM   1256 N ND1 . HIS A 1 164 ? -13.37524 12.97303 -31.29943 1.000 22.76544 ? 164 HIS A ND1 1 
ATOM   1257 C CD2 . HIS A 1 164 ? -11.41334 13.80677 -30.80556 1.000 19.82565 ? 164 HIS A CD2 1 
ATOM   1258 C CE1 . HIS A 1 164 ? -12.54829 12.64654 -32.27941 1.000 21.28779 ? 164 HIS A CE1 1 
ATOM   1259 N NE2 . HIS A 1 164 ? -11.35094 13.12885 -31.99606 1.000 20.70843 ? 164 HIS A NE2 1 
ATOM   1260 N N   . MET A 1 165 ? -13.98238 16.18273 -26.69766 1.000 21.88845 ? 165 MET A N   1 
ATOM   1261 C CA  . MET A 1 165 ? -14.98675 16.29915 -25.63393 1.000 21.60384 ? 165 MET A CA  1 
ATOM   1262 C C   . MET A 1 165 ? -14.47878 17.10042 -24.45439 1.000 20.42255 ? 165 MET A C   1 
ATOM   1263 O O   . MET A 1 165 ? -13.28295 17.20334 -24.20499 1.000 21.81729 ? 165 MET A O   1 
ATOM   1264 C CB  . MET A 1 165 ? -15.41325 14.94401 -25.04397 1.000 26.42638 ? 165 MET A CB  1 
ATOM   1265 C CG  . MET A 1 165 ? -15.55695 13.77679 -25.98954 1.000 36.41996 ? 165 MET A CG  1 
ATOM   1266 S SD  . MET A 1 165 ? -16.28392 12.36904 -25.07857 1.000 39.08693 ? 165 MET A SD  1 
ATOM   1267 C CE  . MET A 1 165 ? -15.10234 11.98492 -23.78396 1.000 33.74480 ? 165 MET A CE  1 
ATOM   1268 N N   . GLU A 1 166 ? -15.44201 17.54805 -23.64753 1.000 21.01457 ? 166 GLU A N   1 
ATOM   1269 C CA  . GLU A 1 166 ? -15.17280 18.18392 -22.36516 1.000 22.28143 ? 166 GLU A CA  1 
ATOM   1270 C C   . GLU A 1 166 ? -15.71144 17.31820 -21.23295 1.000 23.79810 ? 166 GLU A C   1 
ATOM   1271 O O   . GLU A 1 166 ? -16.85377 16.84411 -21.29654 1.000 23.14915 ? 166 GLU A O   1 
ATOM   1272 C CB  . GLU A 1 166 ? -15.80634 19.57619 -22.30266 1.000 22.25939 ? 166 GLU A CB  1 
ATOM   1273 C CG  . GLU A 1 166 ? -15.42006 20.29882 -21.00437 1.000 25.06174 ? 166 GLU A CG  1 
ATOM   1274 C CD  . GLU A 1 166 ? -15.90596 21.71096 -20.97807 1.000 25.92193 ? 166 GLU A CD  1 
ATOM   1275 O OE1 . GLU A 1 166 ? -15.43476 22.54068 -21.79218 1.000 21.49067 ? 166 GLU A OE1 1 
ATOM   1276 O OE2 . GLU A 1 166 ? -16.78333 21.98060 -20.13186 1.000 30.83745 ? 166 GLU A OE2 1 
ATOM   1277 N N   . LEU A 1 167 ? -14.87827 17.09484 -20.21292 1.000 19.57671 ? 167 LEU A N   1 
ATOM   1278 C CA  . LEU A 1 167 ? -15.32045 16.35046 -19.04129 1.000 22.91219 ? 167 LEU A CA  1 
ATOM   1279 C C   . LEU A 1 167 ? -15.98742 17.29160 -18.03866 1.000 40.45100 ? 167 LEU A C   1 
ATOM   1280 O O   . LEU A 1 167 ? -15.82971 18.51696 -18.11135 1.000 34.25589 ? 167 LEU A O   1 
ATOM   1281 C CB  . LEU A 1 167 ? -14.14308 15.63255 -18.39045 1.000 27.80746 ? 167 LEU A CB  1 
ATOM   1282 C CG  . LEU A 1 167 ? -13.42066 14.54913 -19.19446 1.000 31.11860 ? 167 LEU A CG  1 
ATOM   1283 C CD1 . LEU A 1 167 ? -12.33373 13.89052 -18.37405 1.000 34.33191 ? 167 LEU A CD1 1 
ATOM   1284 C CD2 . LEU A 1 167 ? -14.41030 13.51098 -19.71238 1.000 30.27246 ? 167 LEU A CD2 1 
ATOM   1285 N N   . PRO A 1 168 ? -16.73020 16.74453 -17.07260 1.000 51.95997 ? 168 PRO A N   1 
ATOM   1286 C CA  . PRO A 1 168 ? -17.55547 17.60424 -16.20197 1.000 63.41733 ? 168 PRO A CA  1 
ATOM   1287 C C   . PRO A 1 168 ? -16.74795 18.60488 -15.39761 1.000 47.47147 ? 168 PRO A C   1 
ATOM   1288 O O   . PRO A 1 168 ? -17.28623 19.64381 -14.98477 1.000 54.14349 ? 168 PRO A O   1 
ATOM   1289 C CB  . PRO A 1 168 ? -18.25231 16.59366 -15.28196 1.000 64.77082 ? 168 PRO A CB  1 
ATOM   1290 C CG  . PRO A 1 168 ? -17.25871 15.47469 -15.16491 1.000 56.72691 ? 168 PRO A CG  1 
ATOM   1291 C CD  . PRO A 1 168 ? -16.62176 15.36974 -16.54920 1.000 46.56433 ? 168 PRO A CD  1 
ATOM   1292 N N   . THR A 1 169 ? -15.47479 18.32338 -15.17849 1.000 48.43872 ? 169 THR A N   1 
ATOM   1293 C CA  . THR A 1 169 ? -14.58175 19.12570 -14.36137 1.000 43.70711 ? 169 THR A CA  1 
ATOM   1294 C C   . THR A 1 169 ? -13.93297 20.29430 -15.10748 1.000 44.08246 ? 169 THR A C   1 
ATOM   1295 O O   . THR A 1 169 ? -12.98770 20.89026 -14.57921 1.000 51.68582 ? 169 THR A O   1 
ATOM   1296 C CB  . THR A 1 169 ? -13.49712 18.21643 -13.81199 1.000 47.98899 ? 169 THR A CB  1 
ATOM   1297 O OG1 . THR A 1 169 ? -13.24929 17.19096 -14.78654 1.000 44.96262 ? 169 THR A OG1 1 
ATOM   1298 C CG2 . THR A 1 169 ? -13.94090 17.57214 -12.50322 1.000 57.61046 ? 169 THR A CG2 1 
ATOM   1299 N N   . GLY A 1 170 ? -14.37080 20.61079 -16.32692 1.000 30.81463 ? 170 GLY A N   1 
ATOM   1300 C CA  . GLY A 1 170 ? -13.72469 21.66276 -17.09433 1.000 28.25412 ? 170 GLY A CA  1 
ATOM   1301 C C   . GLY A 1 170 ? -12.42552 21.27221 -17.77422 1.000 27.44132 ? 170 GLY A C   1 
ATOM   1302 O O   . GLY A 1 170 ? -11.59954 22.14806 -18.06023 1.000 36.25017 ? 170 GLY A O   1 
ATOM   1303 N N   . VAL A 1 171 ? -12.18756 19.98409 -18.00155 1.000 22.84308 ? 171 VAL A N   1 
ATOM   1304 C CA  . VAL A 1 171 ? -10.96363 19.54199 -18.66526 1.000 21.22454 ? 171 VAL A CA  1 
ATOM   1305 C C   . VAL A 1 171 ? -11.37038 18.83408 -19.94894 1.000 22.22477 ? 171 VAL A C   1 
ATOM   1306 O O   . VAL A 1 171 ? -12.54630 18.54459 -20.17835 1.000 23.15394 ? 171 VAL A O   1 
ATOM   1307 C CB  . VAL A 1 171 ? -10.09622 18.63347 -17.78846 1.000 22.81025 ? 171 VAL A CB  1 
ATOM   1308 C CG1 . VAL A 1 171 ? -9.63748  19.40985 -16.53466 1.000 25.58262 ? 171 VAL A CG1 1 
ATOM   1309 C CG2 . VAL A 1 171 ? -10.86993 17.41240 -17.40854 1.000 26.25181 ? 171 VAL A CG2 1 
ATOM   1310 N N   . HIS A 1 172 ? -10.38249 18.59443 -20.81242 1.000 20.47841 ? 172 HIS A N   1 
ATOM   1311 C CA  . HIS A 1 172 ? -10.66288 18.28693 -22.21209 1.000 20.70866 ? 172 HIS A CA  1 
ATOM   1312 C C   . HIS A 1 172 ? -9.97367  17.00387 -22.65001 1.000 18.73691 ? 172 HIS A C   1 
ATOM   1313 O O   . HIS A 1 172 ? -8.87394  16.67081 -22.19445 1.000 22.23902 ? 172 HIS A O   1 
ATOM   1314 C CB  . HIS A 1 172 ? -10.23911 19.48704 -23.06145 1.000 20.45251 ? 172 HIS A CB  1 
ATOM   1315 C CG  . HIS A 1 172 ? -11.01139 20.70397 -22.69018 1.000 20.42132 ? 172 HIS A CG  1 
ATOM   1316 N ND1 . HIS A 1 172 ? -10.50278 21.72158 -21.90309 1.000 21.04974 ? 172 HIS A ND1 1 
ATOM   1317 C CD2 . HIS A 1 172 ? -12.32111 20.99540 -22.89318 1.000 16.97943 ? 172 HIS A CD2 1 
ATOM   1318 C CE1 . HIS A 1 172 ? -11.45459 22.61823 -21.69292 1.000 21.93058 ? 172 HIS A CE1 1 
ATOM   1319 N NE2 . HIS A 1 172 ? -12.56408 22.20485 -22.28483 1.000 22.64697 ? 172 HIS A NE2 1 
ATOM   1320 N N   . VAL A 1 173 ? -10.65109 16.25705 -23.52824 1.000 19.64389 ? 173 VAL A N   1 
ATOM   1321 C CA  . VAL A 1 173 ? -10.09883 14.98449 -23.98179 1.000 21.29219 ? 173 VAL A CA  1 
ATOM   1322 C C   . VAL A 1 173 ? -10.27528 14.84740 -25.48202 1.000 19.36513 ? 173 VAL A C   1 
ATOM   1323 O O   . VAL A 1 173 ? -11.17851 15.43403 -26.08921 1.000 19.64142 ? 173 VAL A O   1 
ATOM   1324 C CB  . VAL A 1 173 ? -10.72513 13.77950 -23.22008 1.000 21.80687 ? 173 VAL A CB  1 
ATOM   1325 C CG1 . VAL A 1 173 ? -10.31237 13.84491 -21.76951 1.000 25.14148 ? 173 VAL A CG1 1 
ATOM   1326 C CG2 . VAL A 1 173 ? -12.24262 13.78089 -23.32333 1.000 23.11791 ? 173 VAL A CG2 1 
ATOM   1327 N N   . GLY A 1 174 ? -9.38147  14.07399 -26.07806 1.000 18.26666 ? 174 GLY A N   1 
ATOM   1328 C CA  . GLY A 1 174 ? -9.38208  13.96324 -27.52118 1.000 20.57049 ? 174 GLY A CA  1 
ATOM   1329 C C   . GLY A 1 174 ? -8.49186  12.82641 -27.96186 1.000 18.23513 ? 174 GLY A C   1 
ATOM   1330 O O   . GLY A 1 174 ? -8.11793  11.97003 -27.16344 1.000 20.76963 ? 174 GLY A O   1 
ATOM   1331 N N   . THR A 1 175 ? -8.22056  12.79471 -29.26504 1.000 20.60222 ? 175 THR A N   1 
ATOM   1332 C CA  . THR A 1 175 ? -7.53582  11.67882 -29.90437 1.000 23.14300 ? 175 THR A CA  1 
ATOM   1333 C C   . THR A 1 175 ? -6.22973  12.12863 -30.54967 1.000 26.55878 ? 175 THR A C   1 
ATOM   1334 O O   . THR A 1 175 ? -5.98503  13.32092 -30.72860 1.000 19.90767 ? 175 THR A O   1 
ATOM   1335 C CB  . THR A 1 175 ? -8.43351  11.04977 -30.98373 1.000 21.44942 ? 175 THR A CB  1 
ATOM   1336 O OG1 . THR A 1 175 ? -8.58914  11.96961 -32.07251 1.000 21.33853 ? 175 THR A OG1 1 
ATOM   1337 C CG2 . THR A 1 175 ? -9.82356  10.67151 -30.38605 1.000 22.60534 ? 175 THR A CG2 1 
ATOM   1338 N N   . ASP A 1 176 ? -5.38351  11.15659 -30.92933 1.000 23.50629 ? 176 ASP A N   1 
ATOM   1339 C CA  . ASP A 1 176 ? -4.33834  11.45977 -31.89573 1.000 21.56645 ? 176 ASP A CA  1 
ATOM   1340 C C   . ASP A 1 176 ? -4.97327  11.55834 -33.28789 1.000 24.55436 ? 176 ASP A C   1 
ATOM   1341 O O   . ASP A 1 176 ? -6.19126  11.44369 -33.44555 1.000 23.91266 ? 176 ASP A O   1 
ATOM   1342 C CB  . ASP A 1 176 ? -3.20606  10.42910 -31.80996 1.000 25.43702 ? 176 ASP A CB  1 
ATOM   1343 C CG  . ASP A 1 176 ? -3.65415  9.00274  -32.11010 1.000 24.42154 ? 176 ASP A CG  1 
ATOM   1344 O OD1 . ASP A 1 176 ? -4.62886  8.82284  -32.85657 1.000 23.39466 ? 176 ASP A OD1 1 
ATOM   1345 O OD2 . ASP A 1 176 ? -2.98585  8.04789  -31.63769 1.000 27.84698 ? 176 ASP A OD2 1 
ATOM   1346 N N   . LEU A 1 177 ? -4.16070  11.80636 -34.31977 1.000 21.92335 ? 177 LEU A N   1 
ATOM   1347 C CA  . LEU A 1 177 ? -4.74489  12.02966 -35.63964 1.000 20.26364 ? 177 LEU A CA  1 
ATOM   1348 C C   . LEU A 1 177 ? -5.07734  10.73064 -36.35355 1.000 25.49477 ? 177 LEU A C   1 
ATOM   1349 O O   . LEU A 1 177 ? -5.55720  10.76983 -37.49822 1.000 28.40328 ? 177 LEU A O   1 
ATOM   1350 C CB  . LEU A 1 177 ? -3.82648  12.90113 -36.51159 1.000 19.39677 ? 177 LEU A CB  1 
ATOM   1351 C CG  . LEU A 1 177 ? -4.12199  14.41262 -36.45715 1.000 20.96701 ? 177 LEU A CG  1 
ATOM   1352 C CD1 . LEU A 1 177 ? -5.46843  14.73253 -37.05583 1.000 19.91945 ? 177 LEU A CD1 1 
ATOM   1353 C CD2 . LEU A 1 177 ? -4.09722  14.82452 -34.94837 1.000 25.11040 ? 177 LEU A CD2 1 
ATOM   1354 N N   . GLU A 1 178 ? -4.80411  9.58981  -35.72656 1.000 24.19098 ? 178 GLU A N   1 
ATOM   1355 C CA  . GLU A 1 178 ? -5.36426  8.32103  -36.16658 1.000 26.94193 ? 178 GLU A CA  1 
ATOM   1356 C C   . GLU A 1 178 ? -6.64648  7.98492  -35.43052 1.000 27.44212 ? 178 GLU A C   1 
ATOM   1357 O O   . GLU A 1 178 ? -7.15533  6.87276  -35.58096 1.000 28.07110 ? 178 GLU A O   1 
ATOM   1358 C CB  . GLU A 1 178 ? -4.34346  7.19866  -35.98807 1.000 31.12136 ? 178 GLU A CB  1 
ATOM   1359 C CG  . GLU A 1 178 ? -3.24623  7.23686  -37.03532 1.000 38.65112 ? 178 GLU A CG  1 
ATOM   1360 C CD  . GLU A 1 178 ? -2.23105  6.15122  -36.82055 1.000 51.59652 ? 178 GLU A CD  1 
ATOM   1361 O OE1 . GLU A 1 178 ? -2.32650  5.44045  -35.79037 1.000 50.93766 ? 178 GLU A OE1 1 
ATOM   1362 O OE2 . GLU A 1 178 ? -1.33704  6.01463  -37.67566 1.000 43.07378 ? 178 GLU A OE2 1 
ATOM   1363 N N   . GLY A 1 179 ? -7.17549  8.92099  -34.62228 1.000 25.61613 ? 179 GLY A N   1 
ATOM   1364 C CA  . GLY A 1 179 ? -8.49329  8.77460  -34.04097 1.000 25.91365 ? 179 GLY A CA  1 
ATOM   1365 C C   . GLY A 1 179 ? -8.54821  7.93765  -32.79023 1.000 22.53403 ? 179 GLY A C   1 
ATOM   1366 O O   . GLY A 1 179 ? -9.64842  7.56572  -32.34629 1.000 25.16811 ? 179 GLY A O   1 
ATOM   1367 N N   . ASN A 1 180 ? -7.39492  7.61163  -32.20141 1.000 24.65078 ? 180 ASN A N   1 
ATOM   1368 C CA  . ASN A 1 180 ? -7.35250  6.82347  -30.97800 1.000 22.80384 ? 180 ASN A CA  1 
ATOM   1369 C C   . ASN A 1 180 ? -7.30413  7.76067  -29.78126 1.000 24.17399 ? 180 ASN A C   1 
ATOM   1370 O O   . ASN A 1 180 ? -6.42645  8.62085  -29.70645 1.000 20.68352 ? 180 ASN A O   1 
ATOM   1371 C CB  . ASN A 1 180 ? -6.13709  5.91293  -30.96437 1.000 26.88153 ? 180 ASN A CB  1 
ATOM   1372 C CG  . ASN A 1 180 ? -6.29031  4.75661  -31.90873 1.000 29.35235 ? 180 ASN A CG  1 
ATOM   1373 O OD1 . ASN A 1 180 ? -7.33589  4.11838  -31.95204 1.000 31.33305 ? 180 ASN A OD1 1 
ATOM   1374 N ND2 . ASN A 1 180 ? -5.26520  4.48689  -32.66783 1.000 32.59915 ? 180 ASN A ND2 1 
ATOM   1375 N N   . PHE A 1 181 ? -8.21732  7.57051  -28.83877 1.000 24.48774 ? 181 PHE A N   1 
ATOM   1376 C CA  . PHE A 1 181 ? -8.26020  8.48090  -27.70809 1.000 25.39631 ? 181 PHE A CA  1 
ATOM   1377 C C   . PHE A 1 181 ? -6.98532  8.40776  -26.89520 1.000 21.66461 ? 181 PHE A C   1 
ATOM   1378 O O   . PHE A 1 181 ? -6.36897  7.35505  -26.73624 1.000 23.80736 ? 181 PHE A O   1 
ATOM   1379 C CB  . PHE A 1 181 ? -9.44944  8.18737  -26.79685 1.000 24.72866 ? 181 PHE A CB  1 
ATOM   1380 C CG  . PHE A 1 181 ? -10.62456 9.06619  -27.07930 1.000 24.80404 ? 181 PHE A CG  1 
ATOM   1381 C CD1 . PHE A 1 181 ? -10.77989 10.29127 -26.41609 1.000 24.52278 ? 181 PHE A CD1 1 
ATOM   1382 C CD2 . PHE A 1 181 ? -11.56493 8.68851  -28.02382 1.000 21.25148 ? 181 PHE A CD2 1 
ATOM   1383 C CE1 . PHE A 1 181 ? -11.87054 11.11601 -26.69290 1.000 22.13371 ? 181 PHE A CE1 1 
ATOM   1384 C CE2 . PHE A 1 181 ? -12.66605 9.50574  -28.29662 1.000 25.78704 ? 181 PHE A CE2 1 
ATOM   1385 C CZ  . PHE A 1 181 ? -12.81763 10.71503 -27.63241 1.000 25.45134 ? 181 PHE A CZ  1 
ATOM   1386 N N   . TYR A 1 182 ? -6.60685  9.55668  -26.36031 1.000 23.36544 ? 182 TYR A N   1 
ATOM   1387 C CA  . TYR A 1 182 ? -5.73477  9.59807  -25.20319 1.000 24.27916 ? 182 TYR A CA  1 
ATOM   1388 C C   . TYR A 1 182 ? -6.58239  9.31668  -23.96618 1.000 23.91024 ? 182 TYR A C   1 
ATOM   1389 O O   . TYR A 1 182 ? -7.54573  10.04458 -23.68446 1.000 20.94036 ? 182 TYR A O   1 
ATOM   1390 C CB  . TYR A 1 182 ? -5.05296  10.96416 -25.09502 1.000 23.77983 ? 182 TYR A CB  1 
ATOM   1391 C CG  . TYR A 1 182 ? -4.02654  11.25876 -26.17604 1.000 16.70375 ? 182 TYR A CG  1 
ATOM   1392 C CD1 . TYR A 1 182 ? -2.74641  10.72492 -26.09889 1.000 21.17297 ? 182 TYR A CD1 1 
ATOM   1393 C CD2 . TYR A 1 182 ? -4.33118  12.07958 -27.25529 1.000 20.52113 ? 182 TYR A CD2 1 
ATOM   1394 C CE1 . TYR A 1 182 ? -1.78483  11.00335 -27.06485 1.000 22.96287 ? 182 TYR A CE1 1 
ATOM   1395 C CE2 . TYR A 1 182 ? -3.39764  12.33681 -28.22589 1.000 21.17864 ? 182 TYR A CE2 1 
ATOM   1396 C CZ  . TYR A 1 182 ? -2.12272  11.82398 -28.12807 1.000 20.68503 ? 182 TYR A CZ  1 
ATOM   1397 O OH  . TYR A 1 182 ? -1.17811  12.11799 -29.09289 1.000 23.03986 ? 182 TYR A OH  1 
ATOM   1398 N N   . GLY A 1 183 ? -6.25721  8.23851  -23.25974 1.000 24.95406 ? 183 GLY A N   1 
ATOM   1399 C CA  . GLY A 1 183 ? -6.93491  7.89332  -22.03660 1.000 25.30829 ? 183 GLY A CA  1 
ATOM   1400 C C   . GLY A 1 183 ? -8.15803  7.02586  -22.25351 1.000 33.15036 ? 183 GLY A C   1 
ATOM   1401 O O   . GLY A 1 183 ? -8.54931  6.72844  -23.38678 1.000 27.67646 ? 183 GLY A O   1 
ATOM   1402 N N   . PRO A 1 184 ? -8.79581  6.62858  -21.14903 1.000 32.10436 ? 184 PRO A N   1 
ATOM   1403 C CA  . PRO A 1 184 ? -9.89729  5.64529  -21.16128 1.000 29.56000 ? 184 PRO A CA  1 
ATOM   1404 C C   . PRO A 1 184 ? -11.25504 6.29123  -21.43200 1.000 38.85903 ? 184 PRO A C   1 
ATOM   1405 O O   . PRO A 1 184 ? -12.20124 6.15171  -20.65882 1.000 38.63994 ? 184 PRO A O   1 
ATOM   1406 C CB  . PRO A 1 184 ? -9.81651  5.06489  -19.74697 1.000 33.74750 ? 184 PRO A CB  1 
ATOM   1407 C CG  . PRO A 1 184 ? -9.42941  6.26299  -18.91988 1.000 36.95369 ? 184 PRO A CG  1 
ATOM   1408 C CD  . PRO A 1 184 ? -8.45202  7.04904  -19.78012 1.000 32.70334 ? 184 PRO A CD  1 
ATOM   1409 N N   . PHE A 1 185 ? -11.34893 7.01091  -22.54049 1.000 27.26263 ? 185 PHE A N   1 
ATOM   1410 C CA  . PHE A 1 185 ? -12.52537 7.78572  -22.87945 1.000 20.82015 ? 185 PHE A CA  1 
ATOM   1411 C C   . PHE A 1 185 ? -13.09073 7.30532  -24.20495 1.000 24.04855 ? 185 PHE A C   1 
ATOM   1412 O O   . PHE A 1 185 ? -12.38189 6.72443  -25.02742 1.000 30.85212 ? 185 PHE A O   1 
ATOM   1413 C CB  . PHE A 1 185 ? -12.19564 9.28522  -22.95659 1.000 21.71805 ? 185 PHE A CB  1 
ATOM   1414 C CG  . PHE A 1 185 ? -11.52664 9.78951  -21.70195 1.000 22.94892 ? 185 PHE A CG  1 
ATOM   1415 C CD1 . PHE A 1 185 ? -12.24162 9.86355  -20.52275 1.000 25.44838 ? 185 PHE A CD1 1 
ATOM   1416 C CD2 . PHE A 1 185 ? -10.16336 10.09017 -21.69069 1.000 28.82211 ? 185 PHE A CD2 1 
ATOM   1417 C CE1 . PHE A 1 185 ? -11.63667 10.29160 -19.34272 1.000 32.42206 ? 185 PHE A CE1 1 
ATOM   1418 C CE2 . PHE A 1 185 ? -9.55507  10.50819 -20.51436 1.000 21.75366 ? 185 PHE A CE2 1 
ATOM   1419 C CZ  . PHE A 1 185 ? -10.30685 10.60894 -19.33682 1.000 27.50400 ? 185 PHE A CZ  1 
ATOM   1420 N N   . VAL A 1 186 ? -14.38718 7.55620  -24.38617 1.000 24.66652 ? 186 VAL A N   1 
ATOM   1421 C CA  . VAL A 1 186 ? -15.12852 7.18311  -25.58587 1.000 26.98243 ? 186 VAL A CA  1 
ATOM   1422 C C   . VAL A 1 186 ? -15.96094 8.38040  -26.01551 1.000 23.49402 ? 186 VAL A C   1 
ATOM   1423 O O   . VAL A 1 186 ? -16.41909 9.17713  -25.18477 1.000 25.49391 ? 186 VAL A O   1 
ATOM   1424 C CB  . VAL A 1 186 ? -16.03948 5.95485  -25.36504 1.000 28.49591 ? 186 VAL A CB  1 
ATOM   1425 C CG1 . VAL A 1 186 ? -15.21956 4.72214  -25.08476 1.000 25.14453 ? 186 VAL A CG1 1 
ATOM   1426 C CG2 . VAL A 1 186 ? -17.05874 6.22214  -24.23228 1.000 31.31001 ? 186 VAL A CG2 1 
ATOM   1427 N N   . ASP A 1 187 ? -16.17384 8.51213  -27.32815 1.000 25.23124 ? 187 ASP A N   1 
ATOM   1428 C CA  . ASP A 1 187 ? -16.89059 9.68474  -27.82903 1.000 24.01735 ? 187 ASP A CA  1 
ATOM   1429 C C   . ASP A 1 187 ? -18.39495 9.41817  -27.84154 1.000 28.06462 ? 187 ASP A C   1 
ATOM   1430 O O   . ASP A 1 187 ? -19.04968 9.26684  -28.87366 1.000 26.75118 ? 187 ASP A O   1 
ATOM   1431 C CB  . ASP A 1 187 ? -16.35112 10.12527 -29.19197 1.000 22.26629 ? 187 ASP A CB  1 
ATOM   1432 C CG  . ASP A 1 187 ? -16.30010 9.01345  -30.22558 1.000 31.21290 ? 187 ASP A CG  1 
ATOM   1433 O OD1 . ASP A 1 187 ? -16.33248 7.82031  -29.84576 1.000 29.44405 ? 187 ASP A OD1 1 
ATOM   1434 O OD2 . ASP A 1 187 ? -16.19458 9.35434  -31.43708 1.000 27.90718 ? 187 ASP A OD2 1 
ATOM   1435 N N   . ARG A 1 188 ? -18.94987 9.39325  -26.63935 1.000 26.71756 ? 188 ARG A N   1 
ATOM   1436 C CA  . ARG A 1 188 ? -20.39198 9.33231  -26.47317 1.000 28.20805 ? 188 ARG A CA  1 
ATOM   1437 C C   . ARG A 1 188 ? -20.73292 10.12551 -25.22989 1.000 26.57528 ? 188 ARG A C   1 
ATOM   1438 O O   . ARG A 1 188 ? -19.91542 10.23887 -24.30755 1.000 25.44087 ? 188 ARG A O   1 
ATOM   1439 C CB  . ARG A 1 188 ? -20.91507 7.89044  -26.36158 1.000 35.82346 ? 188 ARG A CB  1 
ATOM   1440 C CG  . ARG A 1 188 ? -20.46631 7.16875  -25.12978 1.000 36.36253 ? 188 ARG A CG  1 
ATOM   1441 C CD  . ARG A 1 188 ? -21.11181 5.78216  -24.96907 1.000 52.01991 ? 188 ARG A CD  1 
ATOM   1442 N NE  . ARG A 1 188 ? -22.55467 5.86501  -24.76004 1.000 64.46693 ? 188 ARG A NE  1 
ATOM   1443 C CZ  . ARG A 1 188 ? -23.25586 5.03325  -24.00026 1.000 55.85272 ? 188 ARG A CZ  1 
ATOM   1444 N NH1 . ARG A 1 188 ? -22.67088 4.06287  -23.31638 1.000 69.26767 ? 188 ARG A NH1 1 
ATOM   1445 N NH2 . ARG A 1 188 ? -24.57510 5.18433  -23.91843 1.000 57.25867 ? 188 ARG A NH2 1 
ATOM   1446 N N   . GLN A 1 189 ? -21.91859 10.72386 -25.23770 1.000 29.40706 ? 189 GLN A N   1 
ATOM   1447 C CA  . GLN A 1 189 ? -22.33430 11.57401 -24.12662 1.000 27.57905 ? 189 GLN A CA  1 
ATOM   1448 C C   . GLN A 1 189 ? -22.88902 10.69351 -23.01225 1.000 32.65638 ? 189 GLN A C   1 
ATOM   1449 O O   . GLN A 1 189 ? -24.09439 10.45875 -22.88123 1.000 32.35975 ? 189 GLN A O   1 
ATOM   1450 C CB  . GLN A 1 189 ? -23.33731 12.61994 -24.57098 1.000 31.45127 ? 189 GLN A CB  1 
ATOM   1451 C CG  . GLN A 1 189 ? -23.69000 13.58617 -23.44705 1.000 30.33399 ? 189 GLN A CG  1 
ATOM   1452 C CD  . GLN A 1 189 ? -24.59758 14.68809 -23.93735 1.000 33.34452 ? 189 GLN A CD  1 
ATOM   1453 O OE1 . GLN A 1 189 ? -25.45122 15.17452 -23.19850 1.000 43.26636 ? 189 GLN A OE1 1 
ATOM   1454 N NE2 . GLN A 1 189 ? -24.47263 15.03322 -25.21464 1.000 35.21684 ? 189 GLN A NE2 1 
ATOM   1455 N N   . THR A 1 190 ? -21.96535 10.21072 -22.19460 1.000 30.67054 ? 190 THR A N   1 
ATOM   1456 C CA  . THR A 1 190 ? -22.24799 9.36256  -21.04673 1.000 41.58624 ? 190 THR A CA  1 
ATOM   1457 C C   . THR A 1 190 ? -21.33313 9.78167  -19.90490 1.000 38.85722 ? 190 THR A C   1 
ATOM   1458 O O   . THR A 1 190 ? -20.32669 10.46012 -20.11184 1.000 34.19348 ? 190 THR A O   1 
ATOM   1459 C CB  . THR A 1 190 ? -22.01353 7.89059  -21.36900 1.000 41.62285 ? 190 THR A CB  1 
ATOM   1460 O OG1 . THR A 1 190 ? -22.41543 7.10077  -20.24269 1.000 56.43097 ? 190 THR A OG1 1 
ATOM   1461 C CG2 . THR A 1 190 ? -20.52376 7.66651  -21.67525 1.000 32.25346 ? 190 THR A CG2 1 
ATOM   1462 N N   . ALA A 1 191 ? -21.66383 9.32897  -18.70046 1.000 39.35989 ? 191 ALA A N   1 
ATOM   1463 C CA  . ALA A 1 191 ? -20.87991 9.67608  -17.52371 1.000 35.84026 ? 191 ALA A CA  1 
ATOM   1464 C C   . ALA A 1 191 ? -19.46921 9.13360  -17.65107 1.000 31.85518 ? 191 ALA A C   1 
ATOM   1465 O O   . ALA A 1 191 ? -19.26825 7.92173  -17.78977 1.000 39.56556 ? 191 ALA A O   1 
ATOM   1466 C CB  . ALA A 1 191 ? -21.54919 9.12388  -16.26535 1.000 35.01869 ? 191 ALA A CB  1 
ATOM   1467 N N   . GLN A 1 192 ? -18.49024 10.03879 -17.61426 1.000 35.22899 ? 192 GLN A N   1 
ATOM   1468 C CA  . GLN A 1 192 ? -17.08925 9.69047  -17.75564 1.000 27.98026 ? 192 GLN A CA  1 
ATOM   1469 C C   . GLN A 1 192 ? -16.29679 10.63799 -16.88187 1.000 33.29563 ? 192 GLN A C   1 
ATOM   1470 O O   . GLN A 1 192 ? -16.59192 11.83531 -16.81554 1.000 31.88605 ? 192 GLN A O   1 
ATOM   1471 C CB  . GLN A 1 192 ? -16.57902 9.80444  -19.21229 1.000 27.68736 ? 192 GLN A CB  1 
ATOM   1472 C CG  . GLN A 1 192 ? -17.27468 8.86991  -20.15647 1.000 32.03901 ? 192 GLN A CG  1 
ATOM   1473 C CD  . GLN A 1 192 ? -16.74846 8.93986  -21.59040 1.000 27.72253 ? 192 GLN A CD  1 
ATOM   1474 O OE1 . GLN A 1 192 ? -15.59103 8.59951  -21.86520 1.000 29.37208 ? 192 GLN A OE1 1 
ATOM   1475 N NE2 . GLN A 1 192 ? -17.59483 9.39547  -22.49989 1.000 24.85486 ? 192 GLN A NE2 1 
ATOM   1476 N N   . ALA A 1 193 ? -15.32366 10.09944 -16.18765 1.000 31.42288 ? 193 ALA A N   1 
ATOM   1477 C CA  . ALA A 1 193 ? -14.47497 10.94887 -15.37393 1.000 31.14893 ? 193 ALA A CA  1 
ATOM   1478 C C   . ALA A 1 193 ? -13.02663 10.55570 -15.57723 1.000 30.10242 ? 193 ALA A C   1 
ATOM   1479 O O   . ALA A 1 193 ? -12.70966 9.38682  -15.82291 1.000 30.17284 ? 193 ALA A O   1 
ATOM   1480 C CB  . ALA A 1 193 ? -14.84835 10.85087 -13.92010 1.000 29.72173 ? 193 ALA A CB  1 
ATOM   1481 N N   . ALA A 1 194 ? -12.15663 11.55237 -15.49448 1.000 33.60643 ? 194 ALA A N   1 
ATOM   1482 C CA  . ALA A 1 194 ? -10.71978 11.30827 -15.50151 1.000 26.32115 ? 194 ALA A CA  1 
ATOM   1483 C C   . ALA A 1 194 ? -10.25934 10.77982 -14.15059 1.000 31.35454 ? 194 ALA A C   1 
ATOM   1484 O O   . ALA A 1 194 ? -10.83596 11.10359 -13.11489 1.000 31.36101 ? 194 ALA A O   1 
ATOM   1485 C CB  . ALA A 1 194 ? -9.96469  12.59530 -15.79919 1.000 32.96263 ? 194 ALA A CB  1 
ATOM   1486 N N   . GLY A 1 195 ? -9.20362  9.97742  -14.17559 1.000 34.17659 ? 195 GLY A N   1 
ATOM   1487 C CA  . GLY A 1 195 ? -8.50979  9.62612  -12.95117 1.000 34.87213 ? 195 GLY A CA  1 
ATOM   1488 C C   . GLY A 1 195 ? -7.88999  10.84309 -12.28419 1.000 28.38775 ? 195 GLY A C   1 
ATOM   1489 O O   . GLY A 1 195 ? -7.86959  11.95590 -12.80383 1.000 29.51881 ? 195 GLY A O   1 
ATOM   1490 N N   . THR A 1 196 ? -7.42945  10.62700 -11.05489 1.000 33.20880 ? 196 THR A N   1 
ATOM   1491 C CA  . THR A 1 196 ? -6.72743  11.67408 -10.33808 1.000 32.48639 ? 196 THR A CA  1 
ATOM   1492 C C   . THR A 1 196 ? -5.46205  12.06551 -11.09626 1.000 25.83537 ? 196 THR A C   1 
ATOM   1493 O O   . THR A 1 196 ? -4.71251  11.20692 -11.57087 1.000 35.46469 ? 196 THR A O   1 
ATOM   1494 C CB  . THR A 1 196 ? -6.37926  11.18847 -8.93539  1.000 40.08169 ? 196 THR A CB  1 
ATOM   1495 O OG1 . THR A 1 196 ? -5.57997  12.17509 -8.26959  1.000 49.37609 ? 196 THR A OG1 1 
ATOM   1496 C CG2 . THR A 1 196 ? -5.59510  9.91099  -9.03166  1.000 42.96682 ? 196 THR A CG2 1 
ATOM   1497 N N   . ASP A 1 197 ? -5.24648  13.37069 -11.23064 1.000 27.36204 ? 197 ASP A N   1 
ATOM   1498 C CA  . ASP A 1 197 ? -4.06895  13.90699 -11.88907 1.000 27.57010 ? 197 ASP A CA  1 
ATOM   1499 C C   . ASP A 1 197 ? -2.86988  13.93430 -10.93350 1.000 31.92479 ? 197 ASP A C   1 
ATOM   1500 O O   . ASP A 1 197 ? -2.99472  13.75972 -9.72379  1.000 25.95840 ? 197 ASP A O   1 
ATOM   1501 C CB  . ASP A 1 197 ? -4.35432  15.31613 -12.39070 1.000 22.24338 ? 197 ASP A CB  1 
ATOM   1502 C CG  . ASP A 1 197 ? -3.46361  15.69494 -13.56460 1.000 28.91188 ? 197 ASP A CG  1 
ATOM   1503 O OD1 . ASP A 1 197 ? -2.79193  14.79323 -14.11173 1.000 33.81669 ? 197 ASP A OD1 1 
ATOM   1504 O OD2 . ASP A 1 197 ? -3.45490  16.88160 -13.92144 1.000 34.90458 ? 197 ASP A OD2 1 
ATOM   1505 N N   . THR A 1 198 ? -1.68697  14.17513 -11.49188 1.000 25.78954 ? 198 THR A N   1 
ATOM   1506 C CA  A THR A 1 198 ? -0.47212  14.25472 -10.69736 0.500 23.41235 ? 198 THR A CA  1 
ATOM   1507 C CA  B THR A 1 198 ? -0.44609  14.21105 -10.73014 0.500 23.47385 ? 198 THR A CA  1 
ATOM   1508 C C   . THR A 1 198 ? 0.43231   15.29955 -11.33154 1.000 24.06807 ? 198 THR A C   1 
ATOM   1509 O O   . THR A 1 198 ? 0.31503   15.61596 -12.51015 1.000 23.51605 ? 198 THR A O   1 
ATOM   1510 C CB  A THR A 1 198 ? 0.26024   12.90659 -10.61535 0.500 28.38571 ? 198 THR A CB  1 
ATOM   1511 C CB  B THR A 1 198 ? 0.27477   12.85165 -10.77381 0.500 28.14050 ? 198 THR A CB  1 
ATOM   1512 O OG1 A THR A 1 198 ? 0.90949   12.64460 -11.86105 0.500 38.86522 ? 198 THR A OG1 1 
ATOM   1513 O OG1 B THR A 1 198 ? 1.48643   12.90763 -10.02290 0.500 22.36167 ? 198 THR A OG1 1 
ATOM   1514 C CG2 A THR A 1 198 ? -0.72351  11.78096 -10.32907 0.500 25.17150 ? 198 THR A CG2 1 
ATOM   1515 C CG2 B THR A 1 198 ? 0.62285   12.50173 -12.18137 0.500 39.75123 ? 198 THR A CG2 1 
ATOM   1516 N N   . THR A 1 199 ? 1.33231   15.84915 -10.52379 1.000 19.58658 ? 199 THR A N   1 
ATOM   1517 C CA  . THR A 1 199 ? 2.19945   16.92740 -10.98241 1.000 21.58486 ? 199 THR A CA  1 
ATOM   1518 C C   . THR A 1 199 ? 3.39272   16.36321 -11.75636 1.000 19.56731 ? 199 THR A C   1 
ATOM   1519 O O   . THR A 1 199 ? 3.97015   15.33973 -11.37787 1.000 21.24758 ? 199 THR A O   1 
ATOM   1520 C CB  . THR A 1 199 ? 2.67934   17.75856 -9.78157  1.000 21.59483 ? 199 THR A CB  1 
ATOM   1521 O OG1 . THR A 1 199 ? 1.56779   18.37959 -9.11704  1.000 22.27055 ? 199 THR A OG1 1 
ATOM   1522 C CG2 . THR A 1 199 ? 3.65131   18.82391 -10.24702 1.000 19.98321 ? 199 THR A CG2 1 
ATOM   1523 N N   . ILE A 1 200 ? 3.74742   17.01776 -12.86586 1.000 18.18751 ? 200 ILE A N   1 
ATOM   1524 C CA  . ILE A 1 200 ? 4.76034   16.50565 -13.79439 1.000 17.04343 ? 200 ILE A CA  1 
ATOM   1525 C C   . ILE A 1 200 ? 6.11811   16.99227 -13.28642 1.000 20.78114 ? 200 ILE A C   1 
ATOM   1526 O O   . ILE A 1 200 ? 6.59336   18.07537 -13.62916 1.000 18.35606 ? 200 ILE A O   1 
ATOM   1527 C CB  . ILE A 1 200 ? 4.49544   16.94078 -15.24698 1.000 16.18587 ? 200 ILE A CB  1 
ATOM   1528 C CG1 . ILE A 1 200 ? 3.06348   16.60510 -15.70873 1.000 24.20925 ? 200 ILE A CG1 1 
ATOM   1529 C CG2 . ILE A 1 200 ? 5.54885   16.25460 -16.19750 1.000 19.40378 ? 200 ILE A CG2 1 
ATOM   1530 C CD1 . ILE A 1 200 ? 2.50819   17.54998 -16.82000 1.000 20.78512 ? 200 ILE A CD1 1 
ATOM   1531 N N   . THR A 1 201 ? 6.78079   16.13445 -12.50991 1.000 17.16355 ? 201 THR A N   1 
ATOM   1532 C CA  . THR A 1 201 ? 7.98794   16.50373 -11.77373 1.000 15.63658 ? 201 THR A CA  1 
ATOM   1533 C C   . THR A 1 201 ? 9.10440   17.00790 -12.68215 1.000 17.48043 ? 201 THR A C   1 
ATOM   1534 O O   . THR A 1 201 ? 9.77137   18.00679 -12.36911 1.000 16.82467 ? 201 THR A O   1 
ATOM   1535 C CB  . THR A 1 201 ? 8.44256   15.26956 -10.99497 1.000 19.98685 ? 201 THR A CB  1 
ATOM   1536 O OG1 . THR A 1 201 ? 7.33879   14.85734 -10.17550 1.000 19.09460 ? 201 THR A OG1 1 
ATOM   1537 C CG2 . THR A 1 201 ? 9.66701   15.56683 -10.09384 1.000 19.17059 ? 201 THR A CG2 1 
ATOM   1538 N N   . VAL A 1 202 ? 9.38781   16.28267 -13.76472 1.000 18.36696 ? 202 VAL A N   1 
ATOM   1539 C CA  . VAL A 1 202 ? 10.50617  16.69259 -14.62186 1.000 17.00010 ? 202 VAL A CA  1 
ATOM   1540 C C   . VAL A 1 202 ? 10.25525  18.08610 -15.19567 1.000 15.26468 ? 202 VAL A C   1 
ATOM   1541 O O   . VAL A 1 202 ? 11.21143  18.84724 -15.44328 1.000 16.94975 ? 202 VAL A O   1 
ATOM   1542 C CB  . VAL A 1 202 ? 10.76501  15.63500 -15.71766 1.000 16.87442 ? 202 VAL A CB  1 
ATOM   1543 C CG1 . VAL A 1 202 ? 9.56432   15.50914 -16.69120 1.000 20.59830 ? 202 VAL A CG1 1 
ATOM   1544 C CG2 . VAL A 1 202 ? 12.03812  15.98501 -16.53770 1.000 24.21265 ? 202 VAL A CG2 1 
ATOM   1545 N N   . ASN A 1 203 ? 8.98287   18.44327 -15.42882 1.000 16.48766 ? 203 ASN A N   1 
ATOM   1546 C CA  . ASN A 1 203 ? 8.67453   19.77143 -15.96520 1.000 16.13718 ? 203 ASN A CA  1 
ATOM   1547 C C   . ASN A 1 203 ? 8.83615   20.84015 -14.89644 1.000 17.39998 ? 203 ASN A C   1 
ATOM   1548 O O   . ASN A 1 203 ? 9.26713   21.95902 -15.19103 1.000 17.52001 ? 203 ASN A O   1 
ATOM   1549 C CB  . ASN A 1 203 ? 7.24519   19.83029 -16.52408 1.000 16.22620 ? 203 ASN A CB  1 
ATOM   1550 C CG  . ASN A 1 203 ? 7.09464   19.08995 -17.80535 1.000 18.51669 ? 203 ASN A CG  1 
ATOM   1551 O OD1 . ASN A 1 203 ? 8.01750   18.41886 -18.28183 1.000 17.26219 ? 203 ASN A OD1 1 
ATOM   1552 N ND2 . ASN A 1 203 ? 5.88783   19.15671 -18.36312 1.000 18.90497 ? 203 ASN A ND2 1 
ATOM   1553 N N   . VAL A 1 204 ? 8.48194   20.53101 -13.63996 1.000 15.05125 ? 204 VAL A N   1 
ATOM   1554 C CA  . VAL A 1 204 ? 8.72291   21.49962 -12.56990 1.000 14.37410 ? 204 VAL A CA  1 
ATOM   1555 C C   . VAL A 1 204 ? 10.21357  21.79409 -12.46741 1.000 16.92757 ? 204 VAL A C   1 
ATOM   1556 O O   . VAL A 1 204 ? 10.63580  22.94472 -12.35602 1.000 17.20071 ? 204 VAL A O   1 
ATOM   1557 C CB  . VAL A 1 204 ? 8.15521   20.98507 -11.22650 1.000 14.20319 ? 204 VAL A CB  1 
ATOM   1558 C CG1 . VAL A 1 204 ? 8.49873   21.94427 -10.09847 1.000 16.24850 ? 204 VAL A CG1 1 
ATOM   1559 C CG2 . VAL A 1 204 ? 6.65170   20.77519 -11.28414 1.000 18.90568 ? 204 VAL A CG2 1 
ATOM   1560 N N   . LEU A 1 205 ? 11.03226  20.74260 -12.50334 1.000 13.90235 ? 205 LEU A N   1 
ATOM   1561 C CA  . LEU A 1 205 ? 12.47241  20.91010 -12.44238 1.000 15.24260 ? 205 LEU A CA  1 
ATOM   1562 C C   . LEU A 1 205 ? 12.95932  21.74700 -13.61830 1.000 17.06599 ? 205 LEU A C   1 
ATOM   1563 O O   . LEU A 1 205 ? 13.78016  22.65175 -13.44218 1.000 17.82509 ? 205 LEU A O   1 
ATOM   1564 C CB  . LEU A 1 205 ? 13.13434  19.52430 -12.41864 1.000 16.78073 ? 205 LEU A CB  1 
ATOM   1565 C CG  . LEU A 1 205 ? 12.98910  18.76248 -11.07715 1.000 16.63332 ? 205 LEU A CG  1 
ATOM   1566 C CD1 . LEU A 1 205 ? 13.33648  17.29969 -11.23778 1.000 19.68145 ? 205 LEU A CD1 1 
ATOM   1567 C CD2 . LEU A 1 205 ? 13.82510  19.43081 -9.94334  1.000 17.72747 ? 205 LEU A CD2 1 
ATOM   1568 N N   . ALA A 1 206 ? 12.40860  21.50156 -14.82111 1.000 16.83325 ? 206 ALA A N   1 
ATOM   1569 C CA  . ALA A 1 206 ? 12.81731  22.30502 -15.97643 1.000 16.07699 ? 206 ALA A CA  1 
ATOM   1570 C C   . ALA A 1 206 ? 12.52905  23.77880 -15.72427 1.000 17.23440 ? 206 ALA A C   1 
ATOM   1571 O O   . ALA A 1 206 ? 13.34653  24.65791 -16.04441 1.000 19.58969 ? 206 ALA A O   1 
ATOM   1572 C CB  . ALA A 1 206 ? 12.10261  21.81168 -17.24656 1.000 17.63456 ? 206 ALA A CB  1 
ATOM   1573 N N   . TRP A 1 207 ? 11.36026  24.06425 -15.16078 1.000 15.03408 ? 207 TRP A N   1 
ATOM   1574 C CA  . TRP A 1 207 ? 10.97710  25.44053 -14.92161 1.000 16.51002 ? 207 TRP A CA  1 
ATOM   1575 C C   . TRP A 1 207 ? 11.83658  26.07383 -13.82922 1.000 16.98507 ? 207 TRP A C   1 
ATOM   1576 O O   . TRP A 1 207 ? 12.06578  27.29055 -13.85758 1.000 19.02751 ? 207 TRP A O   1 
ATOM   1577 C CB  . TRP A 1 207 ? 9.47584   25.44581 -14.57986 1.000 19.25592 ? 207 TRP A CB  1 
ATOM   1578 C CG  . TRP A 1 207 ? 8.85094   26.73699 -14.17584 1.000 17.78133 ? 207 TRP A CG  1 
ATOM   1579 C CD1 . TRP A 1 207 ? 8.47894   27.78722 -14.98532 1.000 21.46911 ? 207 TRP A CD1 1 
ATOM   1580 C CD2 . TRP A 1 207 ? 8.48989   27.08080 -12.86248 1.000 17.55965 ? 207 TRP A CD2 1 
ATOM   1581 N NE1 . TRP A 1 207 ? 7.89952   28.78251 -14.21153 1.000 23.71539 ? 207 TRP A NE1 1 
ATOM   1582 C CE2 . TRP A 1 207 ? 7.90750   28.37322 -12.90747 1.000 19.12736 ? 207 TRP A CE2 1 
ATOM   1583 C CE3 . TRP A 1 207 ? 8.63413   26.44225 -11.63494 1.000 19.51537 ? 207 TRP A CE3 1 
ATOM   1584 C CZ2 . TRP A 1 207 ? 7.44152   29.02078 -11.75432 1.000 27.89221 ? 207 TRP A CZ2 1 
ATOM   1585 C CZ3 . TRP A 1 207 ? 8.17527   27.10585 -10.46756 1.000 25.49231 ? 207 TRP A CZ3 1 
ATOM   1586 C CH2 . TRP A 1 207 ? 7.59072   28.37055 -10.55671 1.000 24.54703 ? 207 TRP A CH2 1 
ATOM   1587 N N   . LEU A 1 208 ? 12.27386  25.29222 -12.82610 1.000 16.32905 ? 208 LEU A N   1 
ATOM   1588 C CA  . LEU A 1 208 ? 13.20399  25.85699 -11.85714 1.000 16.39480 ? 208 LEU A CA  1 
ATOM   1589 C C   . LEU A 1 208 ? 14.53440  26.21880 -12.52416 1.000 15.01528 ? 208 LEU A C   1 
ATOM   1590 O O   . LEU A 1 208 ? 15.16015  27.21493 -12.15177 1.000 17.55116 ? 208 LEU A O   1 
ATOM   1591 C CB  . LEU A 1 208 ? 13.44358  24.89960 -10.67779 1.000 15.63193 ? 208 LEU A CB  1 
ATOM   1592 C CG  . LEU A 1 208 ? 12.23332  24.61971 -9.76274  1.000 17.17361 ? 208 LEU A CG  1 
ATOM   1593 C CD1 . LEU A 1 208 ? 12.65421  23.64485 -8.68162  1.000 18.84382 ? 208 LEU A CD1 1 
ATOM   1594 C CD2 . LEU A 1 208 ? 11.72338  25.90617 -9.10580  1.000 18.71908 ? 208 LEU A CD2 1 
ATOM   1595 N N   . TYR A 1 209 ? 14.98556  25.42628 -13.50155 1.000 16.92292 ? 209 TYR A N   1 
ATOM   1596 C CA  . TYR A 1 209 ? 16.16758  25.83434 -14.26518 1.000 18.02186 ? 209 TYR A CA  1 
ATOM   1597 C C   . TYR A 1 209 ? 15.89726  27.11086 -15.04955 1.000 18.62865 ? 209 TYR A C   1 
ATOM   1598 O O   . TYR A 1 209 ? 16.76908  27.98329 -15.13805 1.000 17.74450 ? 209 TYR A O   1 
ATOM   1599 C CB  . TYR A 1 209 ? 16.63415  24.73943 -15.23557 1.000 15.85820 ? 209 TYR A CB  1 
ATOM   1600 C CG  . TYR A 1 209 ? 17.43118  23.62837 -14.59735 1.000 16.96235 ? 209 TYR A CG  1 
ATOM   1601 C CD1 . TYR A 1 209 ? 18.74977  23.82478 -14.21761 1.000 17.64294 ? 209 TYR A CD1 1 
ATOM   1602 C CD2 . TYR A 1 209 ? 16.85484  22.40072 -14.37210 1.000 17.60482 ? 209 TYR A CD2 1 
ATOM   1603 C CE1 . TYR A 1 209 ? 19.46476  22.81328 -13.58265 1.000 16.67253 ? 209 TYR A CE1 1 
ATOM   1604 C CE2 . TYR A 1 209 ? 17.56546  21.36884 -13.75903 1.000 22.44196 ? 209 TYR A CE2 1 
ATOM   1605 C CZ  . TYR A 1 209 ? 18.88297  21.57963 -13.40021 1.000 18.69194 ? 209 TYR A CZ  1 
ATOM   1606 O OH  . TYR A 1 209 ? 19.60696  20.58227 -12.75663 1.000 21.12553 ? 209 TYR A OH  1 
ATOM   1607 N N   . ALA A 1 210 ? 14.72101  27.21460 -15.68500 1.000 17.01865 ? 210 ALA A N   1 
ATOM   1608 C CA  . ALA A 1 210 ? 14.36351  28.47666 -16.34261 1.000 18.41200 ? 210 ALA A CA  1 
ATOM   1609 C C   . ALA A 1 210 ? 14.45386  29.63477 -15.36161 1.000 18.07172 ? 210 ALA A C   1 
ATOM   1610 O O   . ALA A 1 210 ? 14.88330  30.73881 -15.71987 1.000 18.48609 ? 210 ALA A O   1 
ATOM   1611 C CB  . ALA A 1 210 ? 12.94385  28.40174 -16.94814 1.000 18.97242 ? 210 ALA A CB  1 
ATOM   1612 N N   . ALA A 1 211 ? 13.99997  29.41934 -14.13299 1.000 15.28825 ? 211 ALA A N   1 
ATOM   1613 C CA  . ALA A 1 211 ? 14.04139  30.48844 -13.14734 1.000 17.52847 ? 211 ALA A CA  1 
ATOM   1614 C C   . ALA A 1 211 ? 15.47859  30.90113 -12.86026 1.000 22.79021 ? 211 ALA A C   1 
ATOM   1615 O O   . ALA A 1 211 ? 15.78760  32.09241 -12.80605 1.000 20.14402 ? 211 ALA A O   1 
ATOM   1616 C CB  . ALA A 1 211 ? 13.32320  30.05216 -11.86566 1.000 16.02092 ? 211 ALA A CB  1 
ATOM   1617 N N   . VAL A 1 212 ? 16.36706  29.92985 -12.67431 1.000 19.85250 ? 212 VAL A N   1 
ATOM   1618 C CA  . VAL A 1 212 ? 17.78320  30.24373 -12.43158 1.000 18.95750 ? 212 VAL A CA  1 
ATOM   1619 C C   . VAL A 1 212 ? 18.35801  31.04610 -13.59100 1.000 20.72078 ? 212 VAL A C   1 
ATOM   1620 O O   . VAL A 1 212 ? 19.08217  32.03504 -13.38595 1.000 20.15125 ? 212 VAL A O   1 
ATOM   1621 C CB  . VAL A 1 212 ? 18.58136  28.95355 -12.18428 1.000 17.51850 ? 212 VAL A CB  1 
ATOM   1622 C CG1 . VAL A 1 212 ? 20.07331  29.25054 -12.13202 1.000 20.39598 ? 212 VAL A CG1 1 
ATOM   1623 C CG2 . VAL A 1 212 ? 18.14339  28.37061 -10.86126 1.000 20.09941 ? 212 VAL A CG2 1 
ATOM   1624 N N   . ILE A 1 213 ? 18.08139  30.61031 -14.82266 1.000 18.71485 ? 213 ILE A N   1 
ATOM   1625 C CA  . ILE A 1 213 ? 18.58352  31.31274 -16.00353 1.000 19.04572 ? 213 ILE A CA  1 
ATOM   1626 C C   . ILE A 1 213 ? 18.09174  32.75656 -15.99998 1.000 22.86369 ? 213 ILE A C   1 
ATOM   1627 O O   . ILE A 1 213 ? 18.81812  33.66622 -16.41947 1.000 23.81373 ? 213 ILE A O   1 
ATOM   1628 C CB  . ILE A 1 213 ? 18.17986  30.52184 -17.27287 1.000 17.95429 ? 213 ILE A CB  1 
ATOM   1629 C CG1 . ILE A 1 213 ? 18.92464  29.17619 -17.30405 1.000 20.98800 ? 213 ILE A CG1 1 
ATOM   1630 C CG2 . ILE A 1 213 ? 18.46145  31.31232 -18.55820 1.000 22.21533 ? 213 ILE A CG2 1 
ATOM   1631 C CD1 . ILE A 1 213 ? 18.37707  28.16616 -18.25114 1.000 20.04322 ? 213 ILE A CD1 1 
ATOM   1632 N N   . ASN A 1 214 ? 16.89960  33.01465 -15.45600 1.000 19.73827 ? 214 ASN A N   1 
ATOM   1633 C CA  . ASN A 1 214 ? 16.39303  34.38786 -15.43371 1.000 21.15940 ? 214 ASN A CA  1 
ATOM   1634 C C   . ASN A 1 214 ? 16.78023  35.15820 -14.17454 1.000 22.15482 ? 214 ASN A C   1 
ATOM   1635 O O   . ASN A 1 214 ? 16.30200  36.27846 -13.97593 1.000 29.76052 ? 214 ASN A O   1 
ATOM   1636 C CB  . ASN A 1 214 ? 14.88005  34.37910 -15.63320 1.000 28.38631 ? 214 ASN A CB  1 
ATOM   1637 C CG  . ASN A 1 214 ? 14.53753  34.26136 -17.06915 1.000 31.56977 ? 214 ASN A CG  1 
ATOM   1638 O OD1 . ASN A 1 214 ? 14.40599  35.27820 -17.75003 1.000 44.41608 ? 214 ASN A OD1 1 
ATOM   1639 N ND2 . ASN A 1 214 ? 14.51565  33.02435 -17.58962 1.000 27.63045 ? 214 ASN A ND2 1 
ATOM   1640 N N   . GLY A 1 215 ? 17.61121  34.58476 -13.31774 1.000 21.60397 ? 215 GLY A N   1 
ATOM   1641 C CA  . GLY A 1 215 ? 18.07778  35.25998 -12.12365 1.000 22.06104 ? 215 GLY A CA  1 
ATOM   1642 C C   . GLY A 1 215 ? 17.19634  35.10773 -10.90126 1.000 21.31881 ? 215 GLY A C   1 
ATOM   1643 O O   . GLY A 1 215 ? 17.45424  35.75371 -9.87407  1.000 23.50264 ? 215 GLY A O   1 
ATOM   1644 N N   . ASP A 1 216 ? 16.16419  34.28220 -10.97416 1.000 20.87178 ? 216 ASP A N   1 
ATOM   1645 C CA  . ASP A 1 216 ? 15.29212  34.05034 -9.81674  1.000 21.11259 ? 216 ASP A CA  1 
ATOM   1646 C C   . ASP A 1 216 ? 15.86142  32.80974 -9.14494  1.000 25.65159 ? 216 ASP A C   1 
ATOM   1647 O O   . ASP A 1 216 ? 15.59122  31.69101 -9.57517  1.000 25.12701 ? 216 ASP A O   1 
ATOM   1648 C CB  . ASP A 1 216 ? 13.85138  33.87037 -10.28036 1.000 23.40965 ? 216 ASP A CB  1 
ATOM   1649 C CG  . ASP A 1 216 ? 12.84096  34.46950 -9.30992  1.000 25.93777 ? 216 ASP A CG  1 
ATOM   1650 O OD1 . ASP A 1 216 ? 13.22327  34.90416 -8.17953  1.000 27.66450 ? 216 ASP A OD1 1 
ATOM   1651 O OD2 . ASP A 1 216 ? 11.65046  34.50227 -9.68207  1.000 29.60537 ? 216 ASP A OD2 1 
ATOM   1652 N N   . ARG A 1 217 ? 16.71195  33.01057 -8.12413  1.000 19.74237 ? 217 ARG A N   1 
ATOM   1653 C CA  A ARG A 1 217 ? 17.58012  31.97459 -7.57286  0.500 21.96689 ? 217 ARG A CA  1 
ATOM   1654 C CA  B ARG A 1 217 ? 17.54332  31.93529 -7.59361  0.500 21.95598 ? 217 ARG A CA  1 
ATOM   1655 C C   . ARG A 1 217 ? 17.37088  31.70749 -6.09149  1.000 19.33151 ? 217 ARG A C   1 
ATOM   1656 O O   . ARG A 1 217 ? 18.08680  30.87418 -5.51838  1.000 22.68169 ? 217 ARG A O   1 
ATOM   1657 C CB  A ARG A 1 217 ? 19.05973  32.35717 -7.76615  0.500 22.99081 ? 217 ARG A CB  1 
ATOM   1658 C CB  B ARG A 1 217 ? 19.03010  32.21601 -7.92267  0.500 23.16215 ? 217 ARG A CB  1 
ATOM   1659 C CG  A ARG A 1 217 ? 19.65119  32.15907 -9.14712  0.500 28.30401 ? 217 ARG A CG  1 
ATOM   1660 C CG  B ARG A 1 217 ? 19.34838  32.30592 -9.44345  0.500 26.64836 ? 217 ARG A CG  1 
ATOM   1661 C CD  A ARG A 1 217 ? 21.11727  32.61923 -9.12040  0.500 20.92234 ? 217 ARG A CD  1 
ATOM   1662 C CD  B ARG A 1 217 ? 20.80799  32.78248 -9.78818  0.500 28.68636 ? 217 ARG A CD  1 
ATOM   1663 N NE  A ARG A 1 217 ? 21.19315  34.06540 -8.96027  0.500 24.29628 ? 217 ARG A NE  1 
ATOM   1664 N NE  B ARG A 1 217 ? 21.14596  32.53018 -11.19402 0.500 29.66201 ? 217 ARG A NE  1 
ATOM   1665 C CZ  A ARG A 1 217 ? 21.33161  34.70136 -7.80657  0.500 23.73015 ? 217 ARG A CZ  1 
ATOM   1666 C CZ  B ARG A 1 217 ? 21.46580  33.44061 -12.11237 0.500 38.76004 ? 217 ARG A CZ  1 
ATOM   1667 N NH1 A ARG A 1 217 ? 21.54106  34.05023 -6.67397  0.500 28.19576 ? 217 ARG A NH1 1 
ATOM   1668 N NH1 B ARG A 1 217 ? 21.62302  34.72060 -11.80638 0.500 19.31914 ? 217 ARG A NH1 1 
ATOM   1669 N NH2 A ARG A 1 217 ? 21.25583  36.02889 -7.78824  0.500 28.54956 ? 217 ARG A NH2 1 
ATOM   1670 N NH2 B ARG A 1 217 ? 21.64982  33.05096 -13.37480 0.500 23.81556 ? 217 ARG A NH2 1 
ATOM   1671 N N   . TRP A 1 218 ? 16.41985  32.39336 -5.43830  1.000 21.31623 ? 218 TRP A N   1 
ATOM   1672 C CA  . TRP A 1 218 ? 16.34786  32.35527 -3.97581  1.000 21.44944 ? 218 TRP A CA  1 
ATOM   1673 C C   . TRP A 1 218 ? 16.14174  30.95824 -3.41588  1.000 22.73734 ? 218 TRP A C   1 
ATOM   1674 O O   . TRP A 1 218 ? 16.56624  30.69741 -2.28885  1.000 21.44991 ? 218 TRP A O   1 
ATOM   1675 C CB  . TRP A 1 218 ? 15.22436  33.25254 -3.45856  1.000 18.20712 ? 218 TRP A CB  1 
ATOM   1676 C CG  . TRP A 1 218 ? 13.81839  32.83035 -3.91085  1.000 21.41208 ? 218 TRP A CG  1 
ATOM   1677 C CD1 . TRP A 1 218 ? 13.12867  33.28524 -4.99702  1.000 22.66481 ? 218 TRP A CD1 1 
ATOM   1678 C CD2 . TRP A 1 218 ? 12.96930  31.89624 -3.25299  1.000 19.70572 ? 218 TRP A CD2 1 
ATOM   1679 N NE1 . TRP A 1 218 ? 11.88062  32.68130 -5.06057  1.000 21.77903 ? 218 TRP A NE1 1 
ATOM   1680 C CE2 . TRP A 1 218 ? 11.76820  31.82592 -3.99267  1.000 21.09045 ? 218 TRP A CE2 1 
ATOM   1681 C CE3 . TRP A 1 218 ? 13.09681  31.11625 -2.09002  1.000 20.11684 ? 218 TRP A CE3 1 
ATOM   1682 C CZ2 . TRP A 1 218 ? 10.70645  30.99670 -3.61719  1.000 20.85333 ? 218 TRP A CZ2 1 
ATOM   1683 C CZ3 . TRP A 1 218 ? 12.04004  30.28734 -1.71648  1.000 20.64871 ? 218 TRP A CZ3 1 
ATOM   1684 C CH2 . TRP A 1 218 ? 10.86375  30.23648 -2.48207  1.000 21.90921 ? 218 TRP A CH2 1 
ATOM   1685 N N   . PHE A 1 219 ? 15.50310  30.05881 -4.16780  1.000 19.02640 ? 219 PHE A N   1 
ATOM   1686 C CA  . PHE A 1 219 ? 15.12341  28.73713 -3.67125  1.000 19.32624 ? 219 PHE A CA  1 
ATOM   1687 C C   . PHE A 1 219 ? 16.26066  27.72379 -3.71091  1.000 20.72152 ? 219 PHE A C   1 
ATOM   1688 O O   . PHE A 1 219 ? 16.06439  26.59242 -3.24668  1.000 24.70824 ? 219 PHE A O   1 
ATOM   1689 C CB  . PHE A 1 219 ? 13.94391  28.19489 -4.49241  1.000 18.48511 ? 219 PHE A CB  1 
ATOM   1690 C CG  . PHE A 1 219 ? 14.22743  28.17456 -5.97048  1.000 18.70505 ? 219 PHE A CG  1 
ATOM   1691 C CD1 . PHE A 1 219 ? 14.83923  27.07080 -6.54915  1.000 18.00946 ? 219 PHE A CD1 1 
ATOM   1692 C CD2 . PHE A 1 219 ? 13.89302  29.26385 -6.76395  1.000 18.06429 ? 219 PHE A CD2 1 
ATOM   1693 C CE1 . PHE A 1 219 ? 15.17440  27.07099 -7.89549  1.000 19.92610 ? 219 PHE A CE1 1 
ATOM   1694 C CE2 . PHE A 1 219 ? 14.22770  29.27058 -8.12621  1.000 21.35375 ? 219 PHE A CE2 1 
ATOM   1695 C CZ  . PHE A 1 219 ? 14.85854  28.15841 -8.68804  1.000 22.67434 ? 219 PHE A CZ  1 
ATOM   1696 N N   . LEU A 1 220 ? 17.41420  28.06968 -4.29604  1.000 19.47058 ? 220 LEU A N   1 
ATOM   1697 C CA  . LEU A 1 220 ? 18.53542  27.14588 -4.30852  1.000 17.42954 ? 220 LEU A CA  1 
ATOM   1698 C C   . LEU A 1 220 ? 19.06764  26.94619 -2.89994  1.000 27.48864 ? 220 LEU A C   1 
ATOM   1699 O O   . LEU A 1 220 ? 19.40402  27.90976 -2.20177  1.000 24.38435 ? 220 LEU A O   1 
ATOM   1700 C CB  . LEU A 1 220 ? 19.64363  27.66207 -5.22860  1.000 19.00258 ? 220 LEU A CB  1 
ATOM   1701 C CG  . LEU A 1 220 ? 19.23070  27.77969 -6.68806  1.000 20.21218 ? 220 LEU A CG  1 
ATOM   1702 C CD1 . LEU A 1 220 ? 20.36931  28.44617 -7.47957  1.000 21.88206 ? 220 LEU A CD1 1 
ATOM   1703 C CD2 . LEU A 1 220 ? 18.90661  26.38807 -7.28736  1.000 19.65499 ? 220 LEU A CD2 1 
ATOM   1704 N N   . ASN A 1 221 ? 19.13873  25.70036 -2.47844  1.000 23.29076 ? 221 ASN A N   1 
ATOM   1705 C CA  . ASN A 1 221 ? 19.66996  25.42086 -1.15273  1.000 21.53805 ? 221 ASN A CA  1 
ATOM   1706 C C   . ASN A 1 221 ? 21.04092  24.75460 -1.27649  1.000 27.74032 ? 221 ASN A C   1 
ATOM   1707 O O   . ASN A 1 221 ? 21.55389  24.52898 -2.37403  1.000 24.95003 ? 221 ASN A O   1 
ATOM   1708 C CB  . ASN A 1 221 ? 18.67143  24.60890 -0.31287  1.000 22.76399 ? 221 ASN A CB  1 
ATOM   1709 C CG  . ASN A 1 221 ? 18.50352  23.18011 -0.76342  1.000 22.53390 ? 221 ASN A CG  1 
ATOM   1710 O OD1 . ASN A 1 221 ? 19.33866  22.61773 -1.44302  1.000 27.51976 ? 221 ASN A OD1 1 
ATOM   1711 N ND2 . ASN A 1 221 ? 17.39881  22.57452 -0.35183  1.000 26.00600 ? 221 ASN A ND2 1 
ATOM   1712 N N   . ARG A 1 222 ? 21.64604  24.46360 -0.13134  1.000 27.39386 ? 222 ARG A N   1 
ATOM   1713 C CA  . ARG A 1 222 ? 23.02605  24.01875 -0.12474  1.000 30.80049 ? 222 ARG A CA  1 
ATOM   1714 C C   . ARG A 1 222 ? 23.16558  22.50245 -0.21926  1.000 36.12423 ? 222 ARG A C   1 
ATOM   1715 O O   . ARG A 1 222 ? 24.29209  21.99320 -0.16570  1.000 32.47245 ? 222 ARG A O   1 
ATOM   1716 C CB  . ARG A 1 222 ? 23.72445  24.54726 1.13667   1.000 31.87475 ? 222 ARG A CB  1 
ATOM   1717 C CG  . ARG A 1 222 ? 23.14796  24.05076 2.44538   1.000 40.73097 ? 222 ARG A CG  1 
ATOM   1718 C CD  . ARG A 1 222 ? 23.83877  24.77243 3.59670   1.000 48.61116 ? 222 ARG A CD  1 
ATOM   1719 N NE  . ARG A 1 222 ? 23.40605  24.28666 4.89714   1.000 54.58296 ? 222 ARG A NE  1 
ATOM   1720 C CZ  . ARG A 1 222 ? 22.31373  24.70410 5.51976   1.000 59.49313 ? 222 ARG A CZ  1 
ATOM   1721 N NH1 . ARG A 1 222 ? 21.51575  25.61247 4.98104   1.000 60.48747 ? 222 ARG A NH1 1 
ATOM   1722 N NH2 . ARG A 1 222 ? 22.00934  24.19046 6.70706   1.000 48.65294 ? 222 ARG A NH2 1 
ATOM   1723 N N   . PHE A 1 223 ? 22.07305  21.77693 -0.43301  1.000 22.14698 ? 223 PHE A N   1 
ATOM   1724 C CA  . PHE A 1 223 ? 22.08316  20.33609 -0.25634  1.000 24.04933 ? 223 PHE A CA  1 
ATOM   1725 C C   . PHE A 1 223 ? 21.99690  19.58033 -1.56937  1.000 28.47451 ? 223 PHE A C   1 
ATOM   1726 O O   . PHE A 1 223 ? 21.69786  20.12721 -2.62769  1.000 27.13566 ? 223 PHE A O   1 
ATOM   1727 C CB  . PHE A 1 223 ? 20.91832  19.89252 0.62714   1.000 25.44037 ? 223 PHE A CB  1 
ATOM   1728 C CG  . PHE A 1 223 ? 20.91939  20.51935 1.98771   1.000 30.61373 ? 223 PHE A CG  1 
ATOM   1729 C CD1 . PHE A 1 223 ? 21.95380  20.26909 2.87345   1.000 32.19577 ? 223 PHE A CD1 1 
ATOM   1730 C CD2 . PHE A 1 223 ? 19.87697  21.33791 2.38706   1.000 28.22402 ? 223 PHE A CD2 1 
ATOM   1731 C CE1 . PHE A 1 223 ? 21.94713  20.83029 4.13860   1.000 32.50269 ? 223 PHE A CE1 1 
ATOM   1732 C CE2 . PHE A 1 223 ? 19.85961  21.90093 3.64747   1.000 38.06932 ? 223 PHE A CE2 1 
ATOM   1733 C CZ  . PHE A 1 223 ? 20.89573  21.64347 4.52866   1.000 39.31615 ? 223 PHE A CZ  1 
ATOM   1734 N N   . THR A 1 224 ? 22.22285  18.28112 -1.45652  1.000 25.99632 ? 224 THR A N   1 
ATOM   1735 C CA  . THR A 1 224 ? 21.92709  17.32431 -2.50533  1.000 23.83433 ? 224 THR A CA  1 
ATOM   1736 C C   . THR A 1 224 ? 20.95935  16.27989 -1.94194  1.000 25.01354 ? 224 THR A C   1 
ATOM   1737 O O   . THR A 1 224 ? 20.55462  16.32536 -0.76957  1.000 30.84327 ? 224 THR A O   1 
ATOM   1738 C CB  . THR A 1 224 ? 23.22765  16.70787 -3.04864  1.000 27.18588 ? 224 THR A CB  1 
ATOM   1739 O OG1 . THR A 1 224 ? 22.97978  16.06510 -4.31585  1.000 27.84858 ? 224 THR A OG1 1 
ATOM   1740 C CG2 . THR A 1 224 ? 23.80762  15.68587 -2.03569  1.000 27.83292 ? 224 THR A CG2 1 
ATOM   1741 N N   . THR A 1 225 ? 20.57238  15.34112 -2.78749  1.000 23.90668 ? 225 THR A N   1 
ATOM   1742 C CA  . THR A 1 225 ? 19.73221  14.23757 -2.36337  1.000 25.76099 ? 225 THR A CA  1 
ATOM   1743 C C   . THR A 1 225 ? 19.98328  13.08222 -3.30980  1.000 27.90586 ? 225 THR A C   1 
ATOM   1744 O O   . THR A 1 225 ? 20.53987  13.26546 -4.39750  1.000 29.90012 ? 225 THR A O   1 
ATOM   1745 C CB  . THR A 1 225 ? 18.24756  14.61326 -2.35948  1.000 33.63810 ? 225 THR A CB  1 
ATOM   1746 O OG1 . THR A 1 225 ? 17.49187  13.50616 -1.86781  1.000 40.47984 ? 225 THR A OG1 1 
ATOM   1747 C CG2 . THR A 1 225 ? 17.77604  14.93735 -3.77283  1.000 28.30692 ? 225 THR A CG2 1 
ATOM   1748 N N   . THR A 1 226 ? 19.57456  11.88860 -2.88455  1.000 27.05739 ? 226 THR A N   1 
ATOM   1749 C CA  . THR A 1 226 ? 19.55340  10.77932 -3.81733  1.000 28.11316 ? 226 THR A CA  1 
ATOM   1750 C C   . THR A 1 226 ? 18.24868  10.79465 -4.59070  1.000 25.37025 ? 226 THR A C   1 
ATOM   1751 O O   . THR A 1 226 ? 17.24185  11.36677 -4.15875  1.000 26.84043 ? 226 THR A O   1 
ATOM   1752 C CB  . THR A 1 226 ? 19.70483  9.42307  -3.10908  1.000 23.58566 ? 226 THR A CB  1 
ATOM   1753 O OG1 . THR A 1 226 ? 18.49978  9.10735  -2.39940  1.000 26.59273 ? 226 THR A OG1 1 
ATOM   1754 C CG2 . THR A 1 226 ? 20.87963  9.45651  -2.14216  1.000 34.72803 ? 226 THR A CG2 1 
ATOM   1755 N N   . LEU A 1 227 ? 18.27848  10.15714 -5.75344  1.000 24.70200 ? 227 LEU A N   1 
ATOM   1756 C CA  . LEU A 1 227 ? 17.05928  10.03007 -6.53920  1.000 27.36590 ? 227 LEU A CA  1 
ATOM   1757 C C   . LEU A 1 227 ? 15.96696  9.31013  -5.74990  1.000 30.56993 ? 227 LEU A C   1 
ATOM   1758 O O   . LEU A 1 227 ? 14.80160  9.73381  -5.76545  1.000 25.03050 ? 227 LEU A O   1 
ATOM   1759 C CB  . LEU A 1 227 ? 17.37029  9.30651  -7.85335  1.000 26.77195 ? 227 LEU A CB  1 
ATOM   1760 C CG  . LEU A 1 227 ? 16.28340  9.18047  -8.90730  1.000 26.40666 ? 227 LEU A CG  1 
ATOM   1761 C CD1 . LEU A 1 227 ? 15.74907  10.57086 -9.31870  1.000 28.29566 ? 227 LEU A CD1 1 
ATOM   1762 C CD2 . LEU A 1 227 ? 16.81590  8.43513  -10.12216 1.000 28.82298 ? 227 LEU A CD2 1 
ATOM   1763 N N   . ASN A 1 228 ? 16.32668  8.22603  -5.03993  1.000 28.52335 ? 228 ASN A N   1 
ATOM   1764 C CA  . ASN A 1 228 ? 15.34589  7.49184  -4.24043  1.000 32.36312 ? 228 ASN A CA  1 
ATOM   1765 C C   . ASN A 1 228 ? 14.72735  8.37394  -3.16508  1.000 21.52279 ? 228 ASN A C   1 
ATOM   1766 O O   . ASN A 1 228 ? 13.50038  8.40343  -3.01124  1.000 30.04976 ? 228 ASN A O   1 
ATOM   1767 C CB  . ASN A 1 228 ? 15.98707  6.26527  -3.58224  1.000 40.56344 ? 228 ASN A CB  1 
ATOM   1768 C CG  . ASN A 1 228 ? 16.24818  5.13949  -4.55211  1.000 46.28058 ? 228 ASN A CG  1 
ATOM   1769 O OD1 . ASN A 1 228 ? 15.56060  4.99130  -5.57119  1.000 41.82904 ? 228 ASN A OD1 1 
ATOM   1770 N ND2 . ASN A 1 228 ? 17.25342  4.32227  -4.23771  1.000 52.85472 ? 228 ASN A ND2 1 
ATOM   1771 N N   . ASP A 1 229 ? 15.56157  9.07262  -2.38685  1.000 26.79899 ? 229 ASP A N   1 
ATOM   1772 C CA  A ASP A 1 229 ? 15.03436  9.88675  -1.29550  0.500 25.49368 ? 229 ASP A CA  1 
ATOM   1773 C CA  B ASP A 1 229 ? 15.03817  9.89681  -1.29445  0.500 25.49396 ? 229 ASP A CA  1 
ATOM   1774 C C   . ASP A 1 229 ? 14.15305  11.01475 -1.82311  1.000 23.65688 ? 229 ASP A C   1 
ATOM   1775 O O   . ASP A 1 229 ? 13.12930  11.35729 -1.21504  1.000 30.32304 ? 229 ASP A O   1 
ATOM   1776 C CB  A ASP A 1 229 ? 16.19361  10.42357 -0.45804  0.500 27.27461 ? 229 ASP A CB  1 
ATOM   1777 C CB  B ASP A 1 229 ? 16.17634  10.49365 -0.46821  0.500 27.27349 ? 229 ASP A CB  1 
ATOM   1778 C CG  A ASP A 1 229 ? 16.77704  9.35992  0.45969   0.500 32.39786 ? 229 ASP A CG  1 
ATOM   1779 C CG  B ASP A 1 229 ? 15.66415  11.27045 0.74194   0.500 34.03013 ? 229 ASP A CG  1 
ATOM   1780 O OD1 A ASP A 1 229 ? 16.02166  8.43636  0.82882   0.500 40.58018 ? 229 ASP A OD1 1 
ATOM   1781 O OD1 B ASP A 1 229 ? 14.44474  11.22323 1.00740   0.500 37.31876 ? 229 ASP A OD1 1 
ATOM   1782 O OD2 A ASP A 1 229 ? 17.97315  9.43543  0.80772   0.500 31.07423 ? 229 ASP A OD2 1 
ATOM   1783 O OD2 B ASP A 1 229 ? 16.47097  11.92274 1.43563   0.500 51.52243 ? 229 ASP A OD2 1 
ATOM   1784 N N   . PHE A 1 230 ? 14.53284  11.60084 -2.95304  1.000 25.27206 ? 230 PHE A N   1 
ATOM   1785 C CA  . PHE A 1 230 ? 13.65484  12.57876 -3.57422  1.000 24.42979 ? 230 PHE A CA  1 
ATOM   1786 C C   . PHE A 1 230 ? 12.29678  11.97466 -3.91134  1.000 21.31739 ? 230 PHE A C   1 
ATOM   1787 O O   . PHE A 1 230 ? 11.24723  12.56970 -3.64584  1.000 24.96466 ? 230 PHE A O   1 
ATOM   1788 C CB  . PHE A 1 230 ? 14.29260  13.13099 -4.84329  1.000 21.50891 ? 230 PHE A CB  1 
ATOM   1789 C CG  . PHE A 1 230 ? 13.35834  14.01209 -5.57941  1.000 23.90798 ? 230 PHE A CG  1 
ATOM   1790 C CD1 . PHE A 1 230 ? 13.11766  15.30237 -5.11601  1.000 22.89034 ? 230 PHE A CD1 1 
ATOM   1791 C CD2 . PHE A 1 230 ? 12.67636  13.54710 -6.68111  1.000 22.21489 ? 230 PHE A CD2 1 
ATOM   1792 C CE1 . PHE A 1 230 ? 12.20736  16.13426 -5.76059  1.000 21.42875 ? 230 PHE A CE1 1 
ATOM   1793 C CE2 . PHE A 1 230 ? 11.76337  14.37648 -7.32890  1.000 28.70282 ? 230 PHE A CE2 1 
ATOM   1794 C CZ  . PHE A 1 230 ? 11.53842  15.67171 -6.85552  1.000 20.51624 ? 230 PHE A CZ  1 
ATOM   1795 N N   . ASN A 1 231 ? 12.30067  10.82069 -4.56750  1.000 24.38884 ? 231 ASN A N   1 
ATOM   1796 C CA  . ASN A 1 231 ? 11.04344  10.24386 -5.01529  1.000 21.66482 ? 231 ASN A CA  1 
ATOM   1797 C C   . ASN A 1 231 ? 10.13077  9.85429  -3.83991  1.000 25.02662 ? 231 ASN A C   1 
ATOM   1798 O O   . ASN A 1 231 ? 8.90154   9.89160  -3.97306  1.000 27.12113 ? 231 ASN A O   1 
ATOM   1799 C CB  . ASN A 1 231 ? 11.35511  9.06966  -5.91941  1.000 25.38269 ? 231 ASN A CB  1 
ATOM   1800 C CG  . ASN A 1 231 ? 11.66779  9.52007  -7.32502  1.000 27.61992 ? 231 ASN A CG  1 
ATOM   1801 O OD1 . ASN A 1 231 ? 11.18197  10.57741 -7.77129  1.000 26.14034 ? 231 ASN A OD1 1 
ATOM   1802 N ND2 . ASN A 1 231 ? 12.48390  8.74891  -8.02010  1.000 27.25124 ? 231 ASN A ND2 1 
ATOM   1803 N N   . LEU A 1 232 ? 10.69442  9.46810  -2.69767  1.000 29.69285 ? 232 LEU A N   1 
ATOM   1804 C CA  . LEU A 1 232 ? 9.84924   9.24850  -1.52231  1.000 30.65132 ? 232 LEU A CA  1 
ATOM   1805 C C   . LEU A 1 232 ? 9.09266   10.51494 -1.14177  1.000 32.73427 ? 232 LEU A C   1 
ATOM   1806 O O   . LEU A 1 232 ? 7.89483   10.46936 -0.83833  1.000 36.64572 ? 232 LEU A O   1 
ATOM   1807 C CB  . LEU A 1 232 ? 10.68721  8.76748  -0.34509  1.000 36.04520 ? 232 LEU A CB  1 
ATOM   1808 C CG  . LEU A 1 232 ? 11.34231  7.40996  -0.52258  1.000 36.57754 ? 232 LEU A CG  1 
ATOM   1809 C CD1 . LEU A 1 232 ? 12.11058  7.07199  0.71354   1.000 40.15566 ? 232 LEU A CD1 1 
ATOM   1810 C CD2 . LEU A 1 232 ? 10.28485  6.35844  -0.78493  1.000 40.28732 ? 232 LEU A CD2 1 
ATOM   1811 N N   . VAL A 1 233 ? 9.76855   11.66061 -1.17466  1.000 33.30079 ? 233 VAL A N   1 
ATOM   1812 C CA  . VAL A 1 233 ? 9.11872   12.92276 -0.83139  1.000 33.19176 ? 233 VAL A CA  1 
ATOM   1813 C C   . VAL A 1 233 ? 8.11502   13.33586 -1.89912  1.000 38.43317 ? 233 VAL A C   1 
ATOM   1814 O O   . VAL A 1 233 ? 6.97173   13.69055 -1.58917  1.000 37.33310 ? 233 VAL A O   1 
ATOM   1815 C CB  . VAL A 1 233 ? 10.17217  14.01743 -0.61269  1.000 34.53994 ? 233 VAL A CB  1 
ATOM   1816 C CG1 . VAL A 1 233 ? 9.48135   15.38064 -0.47552  1.000 41.19382 ? 233 VAL A CG1 1 
ATOM   1817 C CG2 . VAL A 1 233 ? 11.02104  13.67553 0.57223   1.000 30.09658 ? 233 VAL A CG2 1 
ATOM   1818 N N   . ALA A 1 234 ? 8.53566   13.33893 -3.16618  1.000 31.06929 ? 234 ALA A N   1 
ATOM   1819 C CA  . ALA A 1 234 ? 7.62409   13.67906 -4.25316  1.000 36.95456 ? 234 ALA A CA  1 
ATOM   1820 C C   . ALA A 1 234 ? 6.33173   12.87924 -4.15882  1.000 32.40979 ? 234 ALA A C   1 
ATOM   1821 O O   . ALA A 1 234 ? 5.23642   13.42455 -4.36174  1.000 32.59165 ? 234 ALA A O   1 
ATOM   1822 C CB  . ALA A 1 234 ? 8.30004   13.44065 -5.61030  1.000 37.78605 ? 234 ALA A CB  1 
ATOM   1823 N N   . MET A 1 235 ? 6.43627   11.58612 -3.83171  1.000 31.61678 ? 235 MET A N   1 
ATOM   1824 C CA  . MET A 1 235 ? 5.25335   10.72862 -3.81999  1.000 36.04680 ? 235 MET A CA  1 
ATOM   1825 C C   . MET A 1 235 ? 4.17864   11.29624 -2.90097  1.000 26.09501 ? 235 MET A C   1 
ATOM   1826 O O   . MET A 1 235 ? 3.00586   11.37693 -3.27951  1.000 26.80676 ? 235 MET A O   1 
ATOM   1827 C CB  . MET A 1 235 ? 5.63037   9.30482  -3.40023  1.000 35.78644 ? 235 MET A CB  1 
ATOM   1828 N N   . LYS A 1 236 ? 4.57204   11.73863 -1.70047  1.000 26.78912 ? 236 LYS A N   1 
ATOM   1829 C CA  . LYS A 1 236 ? 3.59967   12.25564 -0.73144  1.000 26.10430 ? 236 LYS A CA  1 
ATOM   1830 C C   . LYS A 1 236 ? 2.88439   13.50430 -1.23559  1.000 20.82286 ? 236 LYS A C   1 
ATOM   1831 O O   . LYS A 1 236 ? 1.71685   13.75296 -0.89010  1.000 25.14213 ? 236 LYS A O   1 
ATOM   1832 C CB  . LYS A 1 236 ? 4.29698   12.55572 0.60795   1.000 30.40416 ? 236 LYS A CB  1 
ATOM   1833 C CG  . LYS A 1 236 ? 3.31541   12.79457 1.73514   1.000 46.47318 ? 236 LYS A CG  1 
ATOM   1834 C CD  . LYS A 1 236 ? 3.86472   13.69554 2.86139   1.000 52.38707 ? 236 LYS A CD  1 
ATOM   1835 C CE  . LYS A 1 236 ? 5.25219   13.30065 3.32482   1.000 50.86144 ? 236 LYS A CE  1 
ATOM   1836 N NZ  . LYS A 1 236 ? 5.54440   13.92445 4.66250   1.000 61.30211 ? 236 LYS A NZ  1 
ATOM   1837 N N   . TYR A 1 237 ? 3.53709   14.29365 -2.09306  1.000 22.58170 ? 237 TYR A N   1 
ATOM   1838 C CA  . TYR A 1 237 ? 2.95553   15.53327 -2.58285  1.000 20.05663 ? 237 TYR A CA  1 
ATOM   1839 C C   . TYR A 1 237 ? 2.28802   15.36975 -3.94790  1.000 19.99486 ? 237 TYR A C   1 
ATOM   1840 O O   . TYR A 1 237 ? 1.92938   16.36631 -4.58425  1.000 22.44756 ? 237 TYR A O   1 
ATOM   1841 C CB  . TYR A 1 237 ? 4.03645   16.61517 -2.61826  1.000 21.84445 ? 237 TYR A CB  1 
ATOM   1842 C CG  . TYR A 1 237 ? 4.43771   16.94161 -1.21440  1.000 23.40046 ? 237 TYR A CG  1 
ATOM   1843 C CD1 . TYR A 1 237 ? 3.64404   17.76642 -0.44394  1.000 25.07008 ? 237 TYR A CD1 1 
ATOM   1844 C CD2 . TYR A 1 237 ? 5.56499   16.38609 -0.64595  1.000 22.72460 ? 237 TYR A CD2 1 
ATOM   1845 C CE1 . TYR A 1 237 ? 3.96996   18.04781 0.85230   1.000 31.15386 ? 237 TYR A CE1 1 
ATOM   1846 C CE2 . TYR A 1 237 ? 5.90200   16.65956 0.67310   1.000 26.77854 ? 237 TYR A CE2 1 
ATOM   1847 C CZ  . TYR A 1 237 ? 5.09918   17.49562 1.40433   1.000 29.62287 ? 237 TYR A CZ  1 
ATOM   1848 O OH  . TYR A 1 237 ? 5.41064   17.77010 2.72581   1.000 32.49585 ? 237 TYR A OH  1 
ATOM   1849 N N   . ASN A 1 238 ? 2.04571   14.12997 -4.36580  1.000 20.40988 ? 238 ASN A N   1 
ATOM   1850 C CA  . ASN A 1 238 ? 1.36361   13.82507 -5.61792  1.000 18.92922 ? 238 ASN A CA  1 
ATOM   1851 C C   . ASN A 1 238 ? 2.15593   14.37036 -6.79769  1.000 18.84359 ? 238 ASN A C   1 
ATOM   1852 O O   . ASN A 1 238 ? 1.58275   14.90845 -7.75007  1.000 22.15175 ? 238 ASN A O   1 
ATOM   1853 C CB  . ASN A 1 238 ? -0.06931  14.34966 -5.61979  1.000 20.31356 ? 238 ASN A CB  1 
ATOM   1854 C CG  . ASN A 1 238 ? -0.92040  13.74796 -6.74742  1.000 25.74252 ? 238 ASN A CG  1 
ATOM   1855 O OD1 . ASN A 1 238 ? -0.65867  12.64469 -7.22756  1.000 28.83886 ? 238 ASN A OD1 1 
ATOM   1856 N ND2 . ASN A 1 238 ? -1.91626  14.48833 -7.18332  1.000 28.97751 ? 238 ASN A ND2 1 
ATOM   1857 N N   . TYR A 1 239 ? 3.46601   14.17507 -6.73730  1.000 22.09866 ? 239 TYR A N   1 
ATOM   1858 C CA  . TYR A 1 239 ? 4.38488   14.39937 -7.85288  1.000 22.01611 ? 239 TYR A CA  1 
ATOM   1859 C C   . TYR A 1 239 ? 4.70697   13.05429 -8.49722  1.000 24.91185 ? 239 TYR A C   1 
ATOM   1860 O O   . TYR A 1 239 ? 4.88596   12.05591 -7.79365  1.000 25.92745 ? 239 TYR A O   1 
ATOM   1861 C CB  . TYR A 1 239 ? 5.68634   15.06920 -7.36493  1.000 21.21192 ? 239 TYR A CB  1 
ATOM   1862 C CG  . TYR A 1 239 ? 5.63163   16.58397 -7.35236  1.000 21.74529 ? 239 TYR A CG  1 
ATOM   1863 C CD1 . TYR A 1 239 ? 4.64031   17.25881 -6.65001  1.000 20.78595 ? 239 TYR A CD1 1 
ATOM   1864 C CD2 . TYR A 1 239 ? 6.58183   17.34239 -8.05096  1.000 21.17513 ? 239 TYR A CD2 1 
ATOM   1865 C CE1 . TYR A 1 239 ? 4.56894   18.63235 -6.64502  1.000 23.16394 ? 239 TYR A CE1 1 
ATOM   1866 C CE2 . TYR A 1 239 ? 6.52947   18.73925 -8.04795  1.000 23.87120 ? 239 TYR A CE2 1 
ATOM   1867 C CZ  . TYR A 1 239 ? 5.50830   19.36977 -7.35340  1.000 27.14334 ? 239 TYR A CZ  1 
ATOM   1868 O OH  . TYR A 1 239 ? 5.39323   20.74311 -7.31148  1.000 27.57919 ? 239 TYR A OH  1 
ATOM   1869 N N   . GLU A 1 240 ? 4.82116   13.03120 -9.83170  1.000 21.20833 ? 240 GLU A N   1 
ATOM   1870 C CA  . GLU A 1 240 ? 5.25690   11.80997 -10.51976 1.000 28.37600 ? 240 GLU A CA  1 
ATOM   1871 C C   . GLU A 1 240 ? 6.66741   11.40327 -10.08352 1.000 24.29762 ? 240 GLU A C   1 
ATOM   1872 O O   . GLU A 1 240 ? 7.51740   12.25953 -9.79344  1.000 21.18213 ? 240 GLU A O   1 
ATOM   1873 C CB  . GLU A 1 240 ? 5.25985   12.01034 -12.03614 1.000 28.62167 ? 240 GLU A CB  1 
ATOM   1874 C CG  . GLU A 1 240 ? 3.98524   11.64654 -12.72938 1.000 35.02552 ? 240 GLU A CG  1 
ATOM   1875 C CD  . GLU A 1 240 ? 4.13769   11.82325 -14.21533 1.000 52.94222 ? 240 GLU A CD  1 
ATOM   1876 O OE1 . GLU A 1 240 ? 5.01618   12.62424 -14.61586 1.000 50.87616 ? 240 GLU A OE1 1 
ATOM   1877 O OE2 . GLU A 1 240 ? 3.40995   11.15237 -14.97852 1.000 69.98418 ? 240 GLU A OE2 1 
ATOM   1878 N N   . PRO A 1 241 ? 6.97227   10.10148 -10.04067 1.000 26.56740 ? 241 PRO A N   1 
ATOM   1879 C CA  . PRO A 1 241 ? 8.36645   9.70605  -9.80127  1.000 28.30825 ? 241 PRO A CA  1 
ATOM   1880 C C   . PRO A 1 241 ? 9.29062   10.24480 -10.88864 1.000 19.93387 ? 241 PRO A C   1 
ATOM   1881 O O   . PRO A 1 241 ? 8.93094   10.28158 -12.07123 1.000 26.82087 ? 241 PRO A O   1 
ATOM   1882 C CB  . PRO A 1 241 ? 8.32457   8.16975  -9.81826  1.000 28.84693 ? 241 PRO A CB  1 
ATOM   1883 C CG  . PRO A 1 241 ? 6.97866   7.78895  -10.28607 1.000 36.21158 ? 241 PRO A CG  1 
ATOM   1884 C CD  . PRO A 1 241 ? 6.06339   8.94388  -10.05946 1.000 28.97320 ? 241 PRO A CD  1 
ATOM   1885 N N   . LEU A 1 242 ? 10.47824  10.66888 -10.46982 1.000 25.15843 ? 242 LEU A N   1 
ATOM   1886 C CA  . LEU A 1 242 ? 11.52388  11.11241 -11.39229 1.000 26.11372 ? 242 LEU A CA  1 
ATOM   1887 C C   . LEU A 1 242 ? 12.38579  9.91688  -11.78298 1.000 23.01524 ? 242 LEU A C   1 
ATOM   1888 O O   . LEU A 1 242 ? 12.97743  9.26922  -10.91008 1.000 27.20906 ? 242 LEU A O   1 
ATOM   1889 C CB  . LEU A 1 242 ? 12.40871  12.17900 -10.75281 1.000 22.78406 ? 242 LEU A CB  1 
ATOM   1890 C CG  . LEU A 1 242 ? 13.33895  12.91240 -11.71567 1.000 24.03134 ? 242 LEU A CG  1 
ATOM   1891 C CD1 . LEU A 1 242 ? 12.54701  13.73646 -12.71463 1.000 23.73066 ? 242 LEU A CD1 1 
ATOM   1892 C CD2 . LEU A 1 242 ? 14.25347  13.79476 -10.89043 1.000 26.02218 ? 242 LEU A CD2 1 
ATOM   1893 N N   . THR A 1 243 ? 12.43865  9.61397  -13.08134 1.000 23.34078 ? 243 THR A N   1 
ATOM   1894 C CA  . THR A 1 243 ? 13.16821  8.46292  -13.59302 1.000 26.52322 ? 243 THR A CA  1 
ATOM   1895 C C   . THR A 1 243 ? 14.55346  8.87264  -14.07048 1.000 28.90393 ? 243 THR A C   1 
ATOM   1896 O O   . THR A 1 243 ? 14.84169  10.05103 -14.28457 1.000 22.96602 ? 243 THR A O   1 
ATOM   1897 C CB  . THR A 1 243 ? 12.40886  7.82550  -14.74947 1.000 22.52915 ? 243 THR A CB  1 
ATOM   1898 O OG1 . THR A 1 243 ? 12.42078  8.72116  -15.87863 1.000 26.87157 ? 243 THR A OG1 1 
ATOM   1899 C CG2 . THR A 1 243 ? 10.97331  7.54268  -14.34508 1.000 29.11009 ? 243 THR A CG2 1 
ATOM   1900 N N   . GLN A 1 244 ? 15.41457  7.87817  -14.29858 1.000 26.33433 ? 244 GLN A N   1 
ATOM   1901 C CA  . GLN A 1 244 ? 16.70535  8.22344  -14.89459 1.000 27.47529 ? 244 GLN A CA  1 
ATOM   1902 C C   . GLN A 1 244 ? 16.53245  8.83807  -16.27162 1.000 26.82364 ? 244 GLN A C   1 
ATOM   1903 O O   . GLN A 1 244 ? 17.32554  9.70211  -16.66928 1.000 26.80554 ? 244 GLN A O   1 
ATOM   1904 C CB  . GLN A 1 244 ? 17.62559  7.00642  -14.98485 1.000 30.90576 ? 244 GLN A CB  1 
ATOM   1905 C CG  . GLN A 1 244 ? 19.05799  7.34759  -15.45857 1.000 29.80631 ? 244 GLN A CG  1 
ATOM   1906 C CD  . GLN A 1 244 ? 19.77797  8.28995  -14.51709 1.000 29.62290 ? 244 GLN A CD  1 
ATOM   1907 O OE1 . GLN A 1 244 ? 19.67792  8.17251  -13.28849 1.000 33.28530 ? 244 GLN A OE1 1 
ATOM   1908 N NE2 . GLN A 1 244 ? 20.50128  9.23307  -15.07636 1.000 27.53328 ? 244 GLN A NE2 1 
ATOM   1909 N N   . ASP A 1 245 ? 15.52783  8.39965  -17.03084 1.000 21.86763 ? 245 ASP A N   1 
ATOM   1910 C CA  . ASP A 1 245 ? 15.29442  9.03575  -18.33110 1.000 22.31974 ? 245 ASP A CA  1 
ATOM   1911 C C   . ASP A 1 245 ? 15.02609  10.52451 -18.16343 1.000 24.90634 ? 245 ASP A C   1 
ATOM   1912 O O   . ASP A 1 245 ? 15.52668  11.34548 -18.94070 1.000 24.16940 ? 245 ASP A O   1 
ATOM   1913 C CB  . ASP A 1 245 ? 14.10801  8.40496  -19.05660 1.000 31.89561 ? 245 ASP A CB  1 
ATOM   1914 C CG  . ASP A 1 245 ? 14.43412  7.08280  -19.71855 1.000 40.48931 ? 245 ASP A CG  1 
ATOM   1915 O OD1 . ASP A 1 245 ? 15.60534  6.64700  -19.74591 1.000 40.94823 ? 245 ASP A OD1 1 
ATOM   1916 O OD2 . ASP A 1 245 ? 13.46530  6.46527  -20.20899 1.000 42.71684 ? 245 ASP A OD2 1 
ATOM   1917 N N   . HIS A 1 246 ? 14.18847  10.88274 -17.18395 1.000 23.17146 ? 246 HIS A N   1 
ATOM   1918 C CA  . HIS A 1 246 ? 13.95939  12.28966 -16.87006 1.000 20.43787 ? 246 HIS A CA  1 
ATOM   1919 C C   . HIS A 1 246 ? 15.24730  12.98863 -16.47707 1.000 21.08642 ? 246 HIS A C   1 
ATOM   1920 O O   . HIS A 1 246 ? 15.50502  14.11603 -16.91108 1.000 21.36399 ? 246 HIS A O   1 
ATOM   1921 C CB  . HIS A 1 246 ? 12.95828  12.43220 -15.73026 1.000 19.25454 ? 246 HIS A CB  1 
ATOM   1922 C CG  . HIS A 1 246 ? 11.60826  11.91209 -16.07140 1.000 25.74340 ? 246 HIS A CG  1 
ATOM   1923 N ND1 . HIS A 1 246 ? 10.75555  11.38729 -15.12902 1.000 28.03087 ? 246 HIS A ND1 1 
ATOM   1924 C CD2 . HIS A 1 246 ? 10.97544  11.80277 -17.26062 1.000 27.86194 ? 246 HIS A CD2 1 
ATOM   1925 C CE1 . HIS A 1 246 ? 9.64460   10.98888 -15.71896 1.000 30.58097 ? 246 HIS A CE1 1 
ATOM   1926 N NE2 . HIS A 1 246 ? 9.74664   11.24092 -17.01149 1.000 30.37778 ? 246 HIS A NE2 1 
ATOM   1927 N N   . VAL A 1 247 ? 16.04293  12.37214 -15.60767 1.000 21.85807 ? 247 VAL A N   1 
ATOM   1928 C CA  . VAL A 1 247 ? 17.32073  12.99062 -15.26572 1.000 24.53161 ? 247 VAL A CA  1 
ATOM   1929 C C   . VAL A 1 247 ? 18.12077  13.29115 -16.53073 1.000 25.27573 ? 247 VAL A C   1 
ATOM   1930 O O   . VAL A 1 247 ? 18.73027  14.36021 -16.66550 1.000 23.41794 ? 247 VAL A O   1 
ATOM   1931 C CB  . VAL A 1 247 ? 18.10355  12.09691 -14.29546 1.000 21.33979 ? 247 VAL A CB  1 
ATOM   1932 C CG1 . VAL A 1 247 ? 19.48899  12.66161 -14.09736 1.000 23.45549 ? 247 VAL A CG1 1 
ATOM   1933 C CG2 . VAL A 1 247 ? 17.37042  12.02297 -12.95229 1.000 23.40506 ? 247 VAL A CG2 1 
ATOM   1934 N N   . ASP A 1 248 ? 18.14800  12.34343 -17.47330 1.000 21.74335 ? 248 ASP A N   1 
ATOM   1935 C CA  . ASP A 1 248 ? 18.94248  12.53093 -18.68560 1.000 18.18275 ? 248 ASP A CA  1 
ATOM   1936 C C   . ASP A 1 248 ? 18.41213  13.66501 -19.53477 1.000 18.53295 ? 248 ASP A C   1 
ATOM   1937 O O   . ASP A 1 248 ? 19.19918  14.39086 -20.14047 1.000 22.50312 ? 248 ASP A O   1 
ATOM   1938 C CB  . ASP A 1 248 ? 18.95395  11.24824 -19.50130 1.000 23.21397 ? 248 ASP A CB  1 
ATOM   1939 C CG  . ASP A 1 248 ? 19.73252  10.12323 -18.82593 1.000 28.57683 ? 248 ASP A CG  1 
ATOM   1940 O OD1 . ASP A 1 248 ? 20.50887  10.40155 -17.89819 1.000 27.47245 ? 248 ASP A OD1 1 
ATOM   1941 O OD2 . ASP A 1 248 ? 19.57995  8.94860  -19.25800 1.000 31.68212 ? 248 ASP A OD2 1 
ATOM   1942 N N   . ILE A 1 249 ? 17.08483  13.80824 -19.64777 1.000 21.00230 ? 249 ILE A N   1 
ATOM   1943 C CA  . ILE A 1 249 ? 16.57952  14.88419 -20.50094 1.000 20.30283 ? 249 ILE A CA  1 
ATOM   1944 C C   . ILE A 1 249 ? 16.80581  16.24631 -19.83949 1.000 21.22467 ? 249 ILE A C   1 
ATOM   1945 O O   . ILE A 1 249 ? 16.80738  17.27274 -20.53831 1.000 21.14476 ? 249 ILE A O   1 
ATOM   1946 C CB  . ILE A 1 249 ? 15.09862  14.69009 -20.92706 1.000 28.79209 ? 249 ILE A CB  1 
ATOM   1947 C CG1 . ILE A 1 249 ? 14.11875  14.96621 -19.81123 1.000 26.74128 ? 249 ILE A CG1 1 
ATOM   1948 C CG2 . ILE A 1 249 ? 14.84406  13.28279 -21.52844 1.000 27.17225 ? 249 ILE A CG2 1 
ATOM   1949 C CD1 . ILE A 1 249 ? 12.65806  15.01830 -20.31148 1.000 30.17696 ? 249 ILE A CD1 1 
ATOM   1950 N N   . LEU A 1 250 ? 17.03660  16.28412 -18.51730 1.000 19.76493 ? 250 LEU A N   1 
ATOM   1951 C CA  . LEU A 1 250 ? 17.41475  17.52825 -17.84163 1.000 16.54190 ? 250 LEU A CA  1 
ATOM   1952 C C   . LEU A 1 250 ? 18.89915  17.86111 -17.99930 1.000 19.52198 ? 250 LEU A C   1 
ATOM   1953 O O   . LEU A 1 250 ? 19.34359  18.91631 -17.53608 1.000 20.57774 ? 250 LEU A O   1 
ATOM   1954 C CB  . LEU A 1 250 ? 17.03170  17.45903 -16.33928 1.000 17.76297 ? 250 LEU A CB  1 
ATOM   1955 C CG  . LEU A 1 250 ? 15.53038  17.60036 -16.02147 1.000 18.81141 ? 250 LEU A CG  1 
ATOM   1956 C CD1 . LEU A 1 250 ? 15.22122  17.14151 -14.58314 1.000 17.46269 ? 250 LEU A CD1 1 
ATOM   1957 C CD2 . LEU A 1 250 ? 15.05965  19.09416 -16.21303 1.000 21.46598 ? 250 LEU A CD2 1 
ATOM   1958 N N   . GLY A 1 251 ? 19.65681  17.01345 -18.67711 1.000 21.78338 ? 251 GLY A N   1 
ATOM   1959 C CA  . GLY A 1 251 ? 21.08943  17.17923 -18.79657 1.000 19.73498 ? 251 GLY A CA  1 
ATOM   1960 C C   . GLY A 1 251 ? 21.51102  18.50898 -19.38932 1.000 17.84352 ? 251 GLY A C   1 
ATOM   1961 O O   . GLY A 1 251 ? 22.39354  19.15844 -18.83932 1.000 19.97063 ? 251 GLY A O   1 
ATOM   1962 N N   . PRO A 1 252 ? 20.93897  18.92906 -20.52889 1.000 18.40248 ? 252 PRO A N   1 
ATOM   1963 C CA  . PRO A 1 252 ? 21.35199  20.21869 -21.11752 1.000 17.76838 ? 252 PRO A CA  1 
ATOM   1964 C C   . PRO A 1 252 ? 21.18182  21.39654 -20.17036 1.000 21.73831 ? 252 PRO A C   1 
ATOM   1965 O O   . PRO A 1 252 ? 22.06721  22.25936 -20.09413 1.000 20.09666 ? 252 PRO A O   1 
ATOM   1966 C CB  . PRO A 1 252 ? 20.45767  20.33241 -22.35870 1.000 19.23375 ? 252 PRO A CB  1 
ATOM   1967 C CG  . PRO A 1 252 ? 20.23840  18.88318 -22.73879 1.000 20.39169 ? 252 PRO A CG  1 
ATOM   1968 C CD  . PRO A 1 252 ? 20.07725  18.16443 -21.45235 1.000 23.85820 ? 252 PRO A CD  1 
ATOM   1969 N N   . LEU A 1 253 ? 20.05303  21.46948 -19.45780 1.000 17.78074 ? 253 LEU A N   1 
ATOM   1970 C CA  . LEU A 1 253 ? 19.84327  22.57562 -18.51910 1.000 17.12034 ? 253 LEU A CA  1 
ATOM   1971 C C   . LEU A 1 253 ? 20.82289  22.49338 -17.36449 1.000 18.43635 ? 253 LEU A C   1 
ATOM   1972 O O   . LEU A 1 253 ? 21.33372  23.51103 -16.87861 1.000 18.83262 ? 253 LEU A O   1 
ATOM   1973 C CB  . LEU A 1 253 ? 18.38560  22.52620 -18.03408 1.000 16.13498 ? 253 LEU A CB  1 
ATOM   1974 C CG  . LEU A 1 253 ? 17.39505  22.96614 -19.12492 1.000 17.26040 ? 253 LEU A CG  1 
ATOM   1975 C CD1 . LEU A 1 253 ? 15.88617  22.72481 -18.75153 1.000 17.15570 ? 253 LEU A CD1 1 
ATOM   1976 C CD2 . LEU A 1 253 ? 17.56842  24.43564 -19.39436 1.000 19.99976 ? 253 LEU A CD2 1 
ATOM   1977 N N   . SER A 1 254 ? 21.04002  21.29399 -16.86415 1.000 17.31802 ? 254 SER A N   1 
ATOM   1978 C CA  . SER A 1 254 ? 21.99807  21.10082 -15.80078 1.000 17.10088 ? 254 SER A CA  1 
ATOM   1979 C C   . SER A 1 254 ? 23.40207  21.53527 -16.22602 1.000 20.31632 ? 254 SER A C   1 
ATOM   1980 O O   . SER A 1 254 ? 24.10778  22.21095 -15.47251 1.000 20.95975 ? 254 SER A O   1 
ATOM   1981 C CB  . SER A 1 254 ? 21.97002  19.63205 -15.39349 1.000 25.06251 ? 254 SER A CB  1 
ATOM   1982 O OG  . SER A 1 254 ? 22.95741  19.40627 -14.42377 1.000 25.61657 ? 254 SER A OG  1 
ATOM   1983 N N   . ALA A 1 255 ? 23.81139  21.17707 -17.44964 1.000 19.21793 ? 255 ALA A N   1 
ATOM   1984 C CA  . ALA A 1 255 ? 25.13934  21.56907 -17.91150 1.000 18.49851 ? 255 ALA A CA  1 
ATOM   1985 C C   . ALA A 1 255 ? 25.21923  23.07347 -18.12023 1.000 20.67200 ? 255 ALA A C   1 
ATOM   1986 O O   . ALA A 1 255 ? 26.25028  23.70194 -17.82893 1.000 24.27072 ? 255 ALA A O   1 
ATOM   1987 C CB  . ALA A 1 255 ? 25.47684  20.82293 -19.19795 1.000 17.43799 ? 255 ALA A CB  1 
ATOM   1988 N N   . GLN A 1 256 ? 24.14689  23.67092 -18.64317 1.000 18.11342 ? 256 GLN A N   1 
ATOM   1989 C CA  . GLN A 1 256 ? 24.18862  25.09322 -18.92744 1.000 21.17847 ? 256 GLN A CA  1 
ATOM   1990 C C   . GLN A 1 256 ? 24.34055  25.90666 -17.65025 1.000 24.47770 ? 256 GLN A C   1 
ATOM   1991 O O   . GLN A 1 256 ? 25.10118  26.88713 -17.61366 1.000 29.27336 ? 256 GLN A O   1 
ATOM   1992 C CB  . GLN A 1 256 ? 22.92368  25.50513 -19.69054 1.000 23.58471 ? 256 GLN A CB  1 
ATOM   1993 C CG  . GLN A 1 256 ? 22.63425  26.97027 -19.61421 1.000 34.51444 ? 256 GLN A CG  1 
ATOM   1994 C CD  . GLN A 1 256 ? 21.49321  27.37534 -20.51925 1.000 41.46464 ? 256 GLN A CD  1 
ATOM   1995 O OE1 . GLN A 1 256 ? 20.85761  26.52849 -21.16432 1.000 34.84323 ? 256 GLN A OE1 1 
ATOM   1996 N NE2 . GLN A 1 256 ? 21.22365  28.67603 -20.57524 1.000 38.01347 ? 256 GLN A NE2 1 
ATOM   1997 N N   . THR A 1 257 ? 23.64717  25.50523 -16.57620 1.000 20.42326 ? 257 THR A N   1 
ATOM   1998 C CA  . THR A 1 257 ? 23.62325  26.29066 -15.35597 1.000 19.15425 ? 257 THR A CA  1 
ATOM   1999 C C   . THR A 1 257 ? 24.64969  25.83139 -14.35087 1.000 18.87027 ? 257 THR A C   1 
ATOM   2000 O O   . THR A 1 257 ? 24.87236  26.53017 -13.35804 1.000 22.05577 ? 257 THR A O   1 
ATOM   2001 C CB  . THR A 1 257 ? 22.24075  26.22852 -14.69089 1.000 21.50664 ? 257 THR A CB  1 
ATOM   2002 O OG1 . THR A 1 257 ? 21.96046  24.87401 -14.33787 1.000 19.18256 ? 257 THR A OG1 1 
ATOM   2003 C CG2 . THR A 1 257 ? 21.15823  26.70444 -15.66852 1.000 18.61305 ? 257 THR A CG2 1 
ATOM   2004 N N   . GLY A 1 258 ? 25.21487  24.64687 -14.54030 1.000 19.17338 ? 258 GLY A N   1 
ATOM   2005 C CA  . GLY A 1 258 ? 26.13943  24.11499 -13.55463 1.000 21.23017 ? 258 GLY A CA  1 
ATOM   2006 C C   . GLY A 1 258 ? 25.50000  23.64290 -12.27892 1.000 24.70249 ? 258 GLY A C   1 
ATOM   2007 O O   . GLY A 1 258 ? 26.18787  23.50018 -11.26379 1.000 25.42448 ? 258 GLY A O   1 
ATOM   2008 N N   . ILE A 1 259 ? 24.19469  23.39590 -12.28925 1.000 18.80447 ? 259 ILE A N   1 
ATOM   2009 C CA  . ILE A 1 259 ? 23.49076  22.84413 -11.14503 1.000 19.74364 ? 259 ILE A CA  1 
ATOM   2010 C C   . ILE A 1 259 ? 23.15761  21.39611 -11.45853 1.000 17.49480 ? 259 ILE A C   1 
ATOM   2011 O O   . ILE A 1 259 ? 22.34443  21.12608 -12.34787 1.000 20.04368 ? 259 ILE A O   1 
ATOM   2012 C CB  . ILE A 1 259 ? 22.21084  23.64555 -10.84578 1.000 18.72948 ? 259 ILE A CB  1 
ATOM   2013 C CG1 . ILE A 1 259 ? 22.54574  25.12602 -10.61040 1.000 22.11948 ? 259 ILE A CG1 1 
ATOM   2014 C CG2 . ILE A 1 259 ? 21.43533  23.00739 -9.69875  1.000 20.93785 ? 259 ILE A CG2 1 
ATOM   2015 C CD1 . ILE A 1 259 ? 21.32571  26.03855 -10.59675 1.000 23.67821 ? 259 ILE A CD1 1 
ATOM   2016 N N   . ALA A 1 260 ? 23.72568  20.47558 -10.67117 1.000 20.65142 ? 260 ALA A N   1 
ATOM   2017 C CA  . ALA A 1 260 ? 23.42812  19.05957 -10.79350 1.000 22.61131 ? 260 ALA A CA  1 
ATOM   2018 C C   . ALA A 1 260 ? 21.93145  18.80771 -10.66419 1.000 23.73392 ? 260 ALA A C   1 
ATOM   2019 O O   . ALA A 1 260 ? 21.23878  19.43161 -9.85480  1.000 20.05375 ? 260 ALA A O   1 
ATOM   2020 C CB  . ALA A 1 260 ? 24.17714  18.27767 -9.69947  1.000 22.30645 ? 260 ALA A CB  1 
ATOM   2021 N N   . VAL A 1 261 ? 21.43243  17.85988 -11.44560 1.000 20.09003 ? 261 VAL A N   1 
ATOM   2022 C CA  . VAL A 1 261 ? 20.00988  17.53161 -11.37060 1.000 20.84058 ? 261 VAL A CA  1 
ATOM   2023 C C   . VAL A 1 261 ? 19.61081  17.14182 -9.94273  1.000 22.04138 ? 261 VAL A C   1 
ATOM   2024 O O   . VAL A 1 261 ? 18.60143  17.60951 -9.42061  1.000 20.21613 ? 261 VAL A O   1 
ATOM   2025 C CB  . VAL A 1 261 ? 19.64607  16.43685 -12.39742 1.000 19.60907 ? 261 VAL A CB  1 
ATOM   2026 C CG1 . VAL A 1 261 ? 18.21725  15.98891 -12.16160 1.000 21.46408 ? 261 VAL A CG1 1 
ATOM   2027 C CG2 . VAL A 1 261 ? 19.81248  16.98196 -13.83641 1.000 21.83348 ? 261 VAL A CG2 1 
ATOM   2028 N N   . LEU A 1 262 ? 20.38511  16.27931 -9.28304  1.000 23.11715 ? 262 LEU A N   1 
ATOM   2029 C CA  . LEU A 1 262 ? 19.98692  15.91523 -7.91953  1.000 23.40800 ? 262 LEU A CA  1 
ATOM   2030 C C   . LEU A 1 262 ? 20.11066  17.08057 -6.93147  1.000 23.29775 ? 262 LEU A C   1 
ATOM   2031 O O   . LEU A 1 262 ? 19.43821  17.06853 -5.88505  1.000 22.49058 ? 262 LEU A O   1 
ATOM   2032 C CB  . LEU A 1 262 ? 20.79538  14.70640 -7.44064  1.000 24.23284 ? 262 LEU A CB  1 
ATOM   2033 C CG  . LEU A 1 262 ? 20.41223  13.41486 -8.15137  1.000 30.07432 ? 262 LEU A CG  1 
ATOM   2034 C CD1 . LEU A 1 262 ? 21.32573  12.28032 -7.68600  1.000 34.69874 ? 262 LEU A CD1 1 
ATOM   2035 C CD2 . LEU A 1 262 ? 18.95010  13.07130 -7.90312  1.000 34.52850 ? 262 LEU A CD2 1 
ATOM   2036 N N   . ASP A 1 263 ? 20.90734  18.10085 -7.24172  1.000 21.89368 ? 263 ASP A N   1 
ATOM   2037 C CA  . ASP A 1 263 ? 20.92441  19.28790 -6.39156  1.000 20.21433 ? 263 ASP A CA  1 
ATOM   2038 C C   . ASP A 1 263 ? 19.66217  20.11750 -6.58539  1.000 21.18257 ? 263 ASP A C   1 
ATOM   2039 O O   . ASP A 1 263 ? 19.08046  20.62081 -5.61226  1.000 23.35944 ? 263 ASP A O   1 
ATOM   2040 C CB  . ASP A 1 263 ? 22.16689  20.13870 -6.66262  1.000 24.62561 ? 263 ASP A CB  1 
ATOM   2041 C CG  . ASP A 1 263 ? 23.47289  19.45937 -6.21921  1.000 26.24769 ? 263 ASP A CG  1 
ATOM   2042 O OD1 . ASP A 1 263 ? 23.47037  18.29524 -5.77111  1.000 26.83644 ? 263 ASP A OD1 1 
ATOM   2043 O OD2 . ASP A 1 263 ? 24.51695  20.10652 -6.35395  1.000 28.27076 ? 263 ASP A OD2 1 
ATOM   2044 N N   . MET A 1 264 ? 19.20791  20.27106 -7.82827  1.000 20.11650 ? 264 MET A N   1 
ATOM   2045 C CA  . MET A 1 264 ? 17.91842  20.92542 -8.02569  1.000 20.07137 ? 264 MET A CA  1 
ATOM   2046 C C   . MET A 1 264 ? 16.80529  20.13309 -7.34618  1.000 19.28689 ? 264 MET A C   1 
ATOM   2047 O O   . MET A 1 264 ? 15.86350  20.71457 -6.79713  1.000 21.22034 ? 264 MET A O   1 
ATOM   2048 C CB  . MET A 1 264 ? 17.66515  21.10760 -9.53301  1.000 16.41368 ? 264 MET A CB  1 
ATOM   2049 C CG  . MET A 1 264 ? 16.49434  22.06307 -9.84464  1.000 20.58468 ? 264 MET A CG  1 
ATOM   2050 S SD  . MET A 1 264 ? 16.82648  23.73868 -9.27070  1.000 20.04146 ? 264 MET A SD  1 
ATOM   2051 C CE  . MET A 1 264 ? 17.60209  24.40029 -10.74939 1.000 21.26243 ? 264 MET A CE  1 
ATOM   2052 N N   . CYS A 1 265 ? 16.89876  18.79771 -7.36897  1.000 17.01992 ? 265 CYS A N   1 
ATOM   2053 C CA  . CYS A 1 265 ? 15.90967  17.98131 -6.67005  1.000 18.08450 ? 265 CYS A CA  1 
ATOM   2054 C C   . CYS A 1 265 ? 15.91035  18.26990 -5.18887  1.000 18.02080 ? 265 CYS A C   1 
ATOM   2055 O O   . CYS A 1 265 ? 14.84248  18.31003 -4.55864  1.000 19.47679 ? 265 CYS A O   1 
ATOM   2056 C CB  . CYS A 1 265 ? 16.16172  16.48973 -6.88529  1.000 20.85078 ? 265 CYS A CB  1 
ATOM   2057 S SG  . CYS A 1 265 ? 15.78312  15.89812 -8.54685  1.000 22.32792 ? 265 CYS A SG  1 
ATOM   2058 N N   . ALA A 1 266 ? 17.08782  18.47437 -4.59678  1.000 22.29814 ? 266 ALA A N   1 
ATOM   2059 C CA  . ALA A 1 266 ? 17.09932  18.85395 -3.18525  1.000 22.58060 ? 266 ALA A CA  1 
ATOM   2060 C C   . ALA A 1 266 ? 16.39595  20.18192 -2.96007  1.000 23.84495 ? 266 ALA A C   1 
ATOM   2061 O O   . ALA A 1 266 ? 15.69083  20.35761 -1.96094  1.000 21.38774 ? 266 ALA A O   1 
ATOM   2062 C CB  . ALA A 1 266 ? 18.53387  18.92372 -2.66034  1.000 16.69773 ? 266 ALA A CB  1 
ATOM   2063 N N   . SER A 1 267 ? 16.56686  21.13376 -3.87719  1.000 20.75439 ? 267 SER A N   1 
ATOM   2064 C CA  . SER A 1 267 ? 15.88951  22.41444 -3.70603  1.000 19.26595 ? 267 SER A CA  1 
ATOM   2065 C C   . SER A 1 267 ? 14.38110  22.26359 -3.87765  1.000 19.89753 ? 267 SER A C   1 
ATOM   2066 O O   . SER A 1 267 ? 13.60032  22.84959 -3.10658  1.000 20.07244 ? 267 SER A O   1 
ATOM   2067 C CB  . SER A 1 267 ? 16.46566  23.44466 -4.67927  1.000 22.03952 ? 267 SER A CB  1 
ATOM   2068 O OG  . SER A 1 267 ? 17.80389  23.77544 -4.32302  1.000 24.12734 ? 267 SER A OG  1 
ATOM   2069 N N   . LEU A 1 268 ? 13.94538  21.46220 -4.84818  1.000 17.87893 ? 268 LEU A N   1 
ATOM   2070 C CA  . LEU A 1 268 ? 12.51326  21.21296 -4.99394  1.000 14.31439 ? 268 LEU A CA  1 
ATOM   2071 C C   . LEU A 1 268 ? 11.94926  20.53014 -3.75570  1.000 20.10444 ? 268 LEU A C   1 
ATOM   2072 O O   . LEU A 1 268 ? 10.84430  20.84655 -3.31414  1.000 20.41359 ? 268 LEU A O   1 
ATOM   2073 C CB  . LEU A 1 268 ? 12.24560  20.35065 -6.23162  1.000 18.00209 ? 268 LEU A CB  1 
ATOM   2074 C CG  . LEU A 1 268 ? 10.80563  19.91680 -6.50531  1.000 17.45333 ? 268 LEU A CG  1 
ATOM   2075 C CD1 . LEU A 1 268 ? 9.78989   21.09567 -6.42856  1.000 18.88951 ? 268 LEU A CD1 1 
ATOM   2076 C CD2 . LEU A 1 268 ? 10.73845  19.21479 -7.87840  1.000 18.54905 ? 268 LEU A CD2 1 
ATOM   2077 N N   . LYS A 1 269 ? 12.67509  19.54365 -3.22461  1.000 19.92109 ? 269 LYS A N   1 
ATOM   2078 C CA  . LYS A 1 269 ? 12.21162  18.83647 -2.03471  1.000 19.66104 ? 269 LYS A CA  1 
ATOM   2079 C C   . LYS A 1 269 ? 11.94610  19.81391 -0.90040  1.000 20.84194 ? 269 LYS A C   1 
ATOM   2080 O O   . LYS A 1 269 ? 10.93836  19.69588 -0.19555  1.000 23.94797 ? 269 LYS A O   1 
ATOM   2081 C CB  . LYS A 1 269 ? 13.25568  17.79125 -1.60863  1.000 22.38494 ? 269 LYS A CB  1 
ATOM   2082 C CG  . LYS A 1 269 ? 12.91028  17.08121 -0.32576  1.000 31.50735 ? 269 LYS A CG  1 
ATOM   2083 C CD  . LYS A 1 269 ? 14.14259  16.44519 0.29268   1.000 31.94779 ? 269 LYS A CD  1 
ATOM   2084 C CE  . LYS A 1 269 ? 14.59596  15.20193 -0.43714  1.000 39.67303 ? 269 LYS A CE  1 
ATOM   2085 N NZ  . LYS A 1 269 ? 15.68569  14.47115 0.31172   1.000 40.76599 ? 269 LYS A NZ  1 
ATOM   2086 N N   . GLU A 1 270 ? 12.83578  20.79981 -0.72365  1.000 20.99720 ? 270 GLU A N   1 
ATOM   2087 C CA  . GLU A 1 270 ? 12.61573  21.79917 0.31773   1.000 21.55982 ? 270 GLU A CA  1 
ATOM   2088 C C   . GLU A 1 270 ? 11.38440  22.65507 0.03855   1.000 22.72029 ? 270 GLU A C   1 
ATOM   2089 O O   . GLU A 1 270 ? 10.61230  22.95726 0.96410   1.000 22.82499 ? 270 GLU A O   1 
ATOM   2090 C CB  . GLU A 1 270 ? 13.86094  22.68327 0.48730   1.000 19.60597 ? 270 GLU A CB  1 
ATOM   2091 C CG  . GLU A 1 270 ? 13.65400  23.74412 1.58088   1.000 29.53037 ? 270 GLU A CG  1 
ATOM   2092 C CD  . GLU A 1 270 ? 14.88621  24.63147 1.84965   1.000 35.10213 ? 270 GLU A CD  1 
ATOM   2093 O OE1 . GLU A 1 270 ? 16.04679  24.15822 1.72445   1.000 35.52879 ? 270 GLU A OE1 1 
ATOM   2094 O OE2 . GLU A 1 270 ? 14.67266  25.81211 2.22275   1.000 40.36945 ? 270 GLU A OE2 1 
ATOM   2095 N N   . LEU A 1 271 ? 11.15841  23.03664 -1.22336  1.000 21.97283 ? 271 LEU A N   1 
ATOM   2096 C CA  . LEU A 1 271 ? 9.94741   23.78598 -1.54879  1.000 21.32285 ? 271 LEU A CA  1 
ATOM   2097 C C   . LEU A 1 271 ? 8.69415   22.98559 -1.22351  1.000 21.85230 ? 271 LEU A C   1 
ATOM   2098 O O   . LEU A 1 271 ? 7.69857   23.54516 -0.74927  1.000 23.78822 ? 271 LEU A O   1 
ATOM   2099 C CB  . LEU A 1 271 ? 9.94855   24.18014 -3.03727  1.000 19.87062 ? 271 LEU A CB  1 
ATOM   2100 C CG  . LEU A 1 271 ? 10.97309  25.24854 -3.42557  1.000 23.39705 ? 271 LEU A CG  1 
ATOM   2101 C CD1 . LEU A 1 271 ? 11.14337  25.29694 -4.96990  1.000 20.34339 ? 271 LEU A CD1 1 
ATOM   2102 C CD2 . LEU A 1 271 ? 10.59505  26.62243 -2.86605  1.000 25.93406 ? 271 LEU A CD2 1 
ATOM   2103 N N   . LEU A 1 272 ? 8.71279   21.68295 -1.49602  1.000 17.81041 ? 272 LEU A N   1 
ATOM   2104 C CA  . LEU A 1 272 ? 7.52661   20.86807 -1.25743  1.000 20.94545 ? 272 LEU A CA  1 
ATOM   2105 C C   . LEU A 1 272 ? 7.25795   20.72148 0.23437   1.000 27.40565 ? 272 LEU A C   1 
ATOM   2106 O O   . LEU A 1 272 ? 6.10363   20.79279 0.67568   1.000 26.05900 ? 272 LEU A O   1 
ATOM   2107 C CB  . LEU A 1 272 ? 7.69389   19.49432 -1.89761  1.000 23.87426 ? 272 LEU A CB  1 
ATOM   2108 C CG  . LEU A 1 272 ? 7.79302   19.48733 -3.42593  1.000 22.23770 ? 272 LEU A CG  1 
ATOM   2109 C CD1 . LEU A 1 272 ? 7.87023   18.06181 -3.92598  1.000 22.43340 ? 272 LEU A CD1 1 
ATOM   2110 C CD2 . LEU A 1 272 ? 6.59919   20.19097 -4.00395  1.000 21.80020 ? 272 LEU A CD2 1 
ATOM   2111 N N   . GLN A 1 273 ? 8.30954   20.49184 1.01575   1.000 21.80523 ? 273 GLN A N   1 
ATOM   2112 C CA  . GLN A 1 273 ? 8.14312   20.28597 2.45559   1.000 25.44793 ? 273 GLN A CA  1 
ATOM   2113 C C   . GLN A 1 273 ? 7.82976   21.57582 3.19678   1.000 31.30794 ? 273 GLN A C   1 
ATOM   2114 O O   . GLN A 1 273 ? 7.10491   21.54728 4.19778   1.000 28.63359 ? 273 GLN A O   1 
ATOM   2115 C CB  . GLN A 1 273 ? 9.40065   19.64083 3.03761   1.000 27.91156 ? 273 GLN A CB  1 
ATOM   2116 C CG  . GLN A 1 273 ? 9.60054   18.22163 2.51713   1.000 27.05064 ? 273 GLN A CG  1 
ATOM   2117 C CD  . GLN A 1 273 ? 10.92501  17.59736 2.96092   1.000 34.97458 ? 273 GLN A CD  1 
ATOM   2118 O OE1 . GLN A 1 273 ? 11.94705  18.26977 3.03727   1.000 37.79879 ? 273 GLN A OE1 1 
ATOM   2119 N NE2 . GLN A 1 273 ? 10.90043  16.30329 3.24881   1.000 34.70555 ? 273 GLN A NE2 1 
ATOM   2120 N N   . ASN A 1 274 ? 8.34849   22.71003 2.73519   1.000 26.79425 ? 274 ASN A N   1 
ATOM   2121 C CA  . ASN A 1 274 ? 8.24580   23.95972 3.47240   1.000 22.69501 ? 274 ASN A CA  1 
ATOM   2122 C C   . ASN A 1 274 ? 7.36633   25.00649 2.81640   1.000 35.15459 ? 274 ASN A C   1 
ATOM   2123 O O   . ASN A 1 274 ? 7.02710   25.99007 3.48163   1.000 36.03004 ? 274 ASN A O   1 
ATOM   2124 C CB  . ASN A 1 274 ? 9.63897   24.57271 3.68712   1.000 28.95057 ? 274 ASN A CB  1 
ATOM   2125 C CG  . ASN A 1 274 ? 10.54727  23.68488 4.50290   1.000 34.05618 ? 274 ASN A CG  1 
ATOM   2126 O OD1 . ASN A 1 274 ? 11.76182  23.68365 4.31380   1.000 54.62034 ? 274 ASN A OD1 1 
ATOM   2127 N ND2 . ASN A 1 274 ? 9.96629   22.90950 5.39996   1.000 46.45197 ? 274 ASN A ND2 1 
ATOM   2128 N N   . GLY A 1 275 ? 7.00269   24.84138 1.53545   1.000 28.88974 ? 275 GLY A N   1 
ATOM   2129 C CA  . GLY A 1 275 ? 6.23450   25.84687 0.82776   1.000 28.20796 ? 275 GLY A CA  1 
ATOM   2130 C C   . GLY A 1 275 ? 7.11537   27.00286 0.39034   1.000 28.68936 ? 275 GLY A C   1 
ATOM   2131 O O   . GLY A 1 275 ? 8.34442   26.97299 0.51252   1.000 27.83721 ? 275 GLY A O   1 
ATOM   2132 N N   . MET A 1 276 ? 6.47287   28.04695 -0.11958  1.000 28.53313 ? 276 MET A N   1 
ATOM   2133 C CA  . MET A 1 276 ? 7.21858   29.16615 -0.67128  1.000 30.09403 ? 276 MET A CA  1 
ATOM   2134 C C   . MET A 1 276 ? 7.21069   30.40676 0.21247   1.000 35.75863 ? 276 MET A C   1 
ATOM   2135 O O   . MET A 1 276 ? 7.90456   31.37571 -0.10316  1.000 34.93179 ? 276 MET A O   1 
ATOM   2136 C CB  . MET A 1 276 ? 6.70089   29.48969 -2.07776  1.000 30.08570 ? 276 MET A CB  1 
ATOM   2137 C CG  . MET A 1 276 ? 7.18186   28.42524 -3.10450  1.000 37.18215 ? 276 MET A CG  1 
ATOM   2138 S SD  . MET A 1 276 ? 6.22581   28.33862 -4.59344  1.000 59.36852 ? 276 MET A SD  1 
ATOM   2139 C CE  . MET A 1 276 ? 6.79944   29.82659 -5.34953  1.000 25.16724 ? 276 MET A CE  1 
ATOM   2140 N N   . ASN A 1 277 ? 6.45965   30.40495 1.31215   1.000 45.82296 ? 277 ASN A N   1 
ATOM   2141 C CA  . ASN A 1 277 ? 6.45541   31.52109 2.26114   1.000 39.41756 ? 277 ASN A CA  1 
ATOM   2142 C C   . ASN A 1 277 ? 6.11250   32.84441 1.58906   1.000 31.21108 ? 277 ASN A C   1 
ATOM   2143 O O   . ASN A 1 277 ? 6.75721   33.86790 1.82440   1.000 45.34271 ? 277 ASN A O   1 
ATOM   2144 C CB  . ASN A 1 277 ? 7.79275   31.62633 2.98364   1.000 46.73415 ? 277 ASN A CB  1 
ATOM   2145 C CG  . ASN A 1 277 ? 7.81626   30.81271 4.22842   1.000 61.66118 ? 277 ASN A CG  1 
ATOM   2146 O OD1 . ASN A 1 277 ? 7.27240   31.21990 5.25560   1.000 73.66466 ? 277 ASN A OD1 1 
ATOM   2147 N ND2 . ASN A 1 277 ? 8.42060   29.63263 4.14997   1.000 64.91147 ? 277 ASN A ND2 1 
ATOM   2148 N N   . GLY A 1 278 ? 5.06534   32.82137 0.77073   1.000 35.02885 ? 278 GLY A N   1 
ATOM   2149 C CA  . GLY A 1 278 ? 4.58731   34.00976 0.10460   1.000 37.00726 ? 278 GLY A CA  1 
ATOM   2150 C C   . GLY A 1 278 ? 5.48953   34.53623 -0.98319  1.000 46.08328 ? 278 GLY A C   1 
ATOM   2151 O O   . GLY A 1 278 ? 5.20667   35.60489 -1.53723  1.000 37.37621 ? 278 GLY A O   1 
ATOM   2152 N N   . ARG A 1 279 ? 6.56109   33.82727 -1.31084  1.000 32.30970 ? 279 ARG A N   1 
ATOM   2153 C CA  . ARG A 1 279 ? 7.41649   34.23527 -2.41041  1.000 27.01800 ? 279 ARG A CA  1 
ATOM   2154 C C   . ARG A 1 279 ? 6.90959   33.65079 -3.71518  1.000 26.90201 ? 279 ARG A C   1 
ATOM   2155 O O   . ARG A 1 279 ? 6.07275   32.74664 -3.73888  1.000 30.15742 ? 279 ARG A O   1 
ATOM   2156 C CB  . ARG A 1 279 ? 8.85710   33.79928 -2.16886  1.000 26.64888 ? 279 ARG A CB  1 
ATOM   2157 C CG  . ARG A 1 279 ? 9.46536   34.46160 -0.94768  1.000 38.03388 ? 279 ARG A CG  1 
ATOM   2158 C CD  . ARG A 1 279 ? 10.97179  34.47163 -1.00686  1.000 34.63321 ? 279 ARG A CD  1 
ATOM   2159 N NE  . ARG A 1 279 ? 11.43139  35.31527 -2.10298  1.000 34.39339 ? 279 ARG A NE  1 
ATOM   2160 C CZ  . ARG A 1 279 ? 12.68144  35.72273 -2.27829  1.000 40.14124 ? 279 ARG A CZ  1 
ATOM   2161 N NH1 . ARG A 1 279 ? 13.63745  35.40876 -1.42136  1.000 31.90175 ? 279 ARG A NH1 1 
ATOM   2162 N NH2 . ARG A 1 279 ? 12.97422  36.47500 -3.33656  1.000 41.06662 ? 279 ARG A NH2 1 
ATOM   2163 N N   . THR A 1 280 ? 7.42134   34.19901 -4.80865  1.000 22.22736 ? 280 THR A N   1 
ATOM   2164 C CA  . THR A 1 280 ? 7.08548   33.75176 -6.14867  1.000 19.00300 ? 280 THR A CA  1 
ATOM   2165 C C   . THR A 1 280 ? 8.35503   33.29847 -6.85315  1.000 19.64663 ? 280 THR A C   1 
ATOM   2166 O O   . THR A 1 280 ? 9.46815   33.64697 -6.45791  1.000 22.58689 ? 280 THR A O   1 
ATOM   2167 C CB  . THR A 1 280 ? 6.40886   34.85762 -6.96438  1.000 26.62662 ? 280 THR A CB  1 
ATOM   2168 O OG1 . THR A 1 280 ? 7.26615   36.00192 -7.03088  1.000 24.26885 ? 280 THR A OG1 1 
ATOM   2169 C CG2 . THR A 1 280 ? 5.08656   35.26462 -6.31847  1.000 29.84216 ? 280 THR A CG2 1 
ATOM   2170 N N   . ILE A 1 281 ? 8.16453   32.49373 -7.89455  1.000 19.43904 ? 281 ILE A N   1 
ATOM   2171 C CA  . ILE A 1 281 ? 9.24613   32.08027 -8.79333  1.000 20.02971 ? 281 ILE A CA  1 
ATOM   2172 C C   . ILE A 1 281 ? 8.76602   32.39440 -10.20441 1.000 20.53876 ? 281 ILE A C   1 
ATOM   2173 O O   . ILE A 1 281 ? 7.67163   31.96345 -10.60689 1.000 19.40091 ? 281 ILE A O   1 
ATOM   2174 C CB  . ILE A 1 281 ? 9.60754   30.58684 -8.62223  1.000 15.43406 ? 281 ILE A CB  1 
ATOM   2175 C CG1 . ILE A 1 281 ? 10.16306  30.30071 -7.21262  1.000 19.28141 ? 281 ILE A CG1 1 
ATOM   2176 C CG2 . ILE A 1 281 ? 10.63597  30.18045 -9.69696  1.000 18.46456 ? 281 ILE A CG2 1 
ATOM   2177 C CD1 . ILE A 1 281 ? 10.27688  28.81015 -6.84227  1.000 20.25364 ? 281 ILE A CD1 1 
ATOM   2178 N N   . LEU A 1 282 ? 9.54533   33.19097 -10.94984 1.000 19.78245 ? 282 LEU A N   1 
ATOM   2179 C CA  . LEU A 1 282 ? 9.10928   33.66664 -12.26693 1.000 22.83461 ? 282 LEU A CA  1 
ATOM   2180 C C   . LEU A 1 282 ? 7.70021   34.24032 -12.20173 1.000 24.52176 ? 282 LEU A C   1 
ATOM   2181 O O   . LEU A 1 282 ? 6.88096   34.04224 -13.10652 1.000 23.62249 ? 282 LEU A O   1 
ATOM   2182 C CB  . LEU A 1 282 ? 9.19448   32.56050 -13.32348 1.000 17.09901 ? 282 LEU A CB  1 
ATOM   2183 C CG  . LEU A 1 282 ? 10.63567  32.15282 -13.69600 1.000 21.68331 ? 282 LEU A CG  1 
ATOM   2184 C CD1 . LEU A 1 282 ? 10.70879  30.85249 -14.53643 1.000 21.52280 ? 282 LEU A CD1 1 
ATOM   2185 C CD2 . LEU A 1 282 ? 11.38433  33.29443 -14.41324 1.000 21.04322 ? 282 LEU A CD2 1 
ATOM   2186 N N   . GLY A 1 283 ? 7.40996   34.93056 -11.10465 1.000 20.08846 ? 283 GLY A N   1 
ATOM   2187 C CA  . GLY A 1 283 ? 6.13285   35.58655 -10.94601 1.000 25.59133 ? 283 GLY A CA  1 
ATOM   2188 C C   . GLY A 1 283 ? 4.99416   34.70452 -10.47908 1.000 30.11681 ? 283 GLY A C   1 
ATOM   2189 O O   . GLY A 1 283 ? 3.90907   35.22999 -10.19947 1.000 31.99266 ? 283 GLY A O   1 
ATOM   2190 N N   . SER A 1 284 ? 5.19994   33.39188 -10.38089 1.000 24.09093 ? 284 SER A N   1 
ATOM   2191 C CA  A SER A 1 284 ? 4.15802   32.45558 -9.98157  0.500 22.79289 ? 284 SER A CA  1 
ATOM   2192 C CA  B SER A 1 284 ? 4.16631   32.44533 -9.98084  0.500 22.79306 ? 284 SER A CA  1 
ATOM   2193 C C   . SER A 1 284 ? 4.24072   32.13450 -8.49276  1.000 23.09425 ? 284 SER A C   1 
ATOM   2194 O O   . SER A 1 284 ? 5.32224   31.93984 -7.94009  1.000 22.07254 ? 284 SER A O   1 
ATOM   2195 C CB  A SER A 1 284 ? 4.25958   31.16159 -10.79031 0.500 22.28218 ? 284 SER A CB  1 
ATOM   2196 C CB  B SER A 1 284 ? 4.30459   31.14355 -10.76541 0.500 22.24108 ? 284 SER A CB  1 
ATOM   2197 O OG  A SER A 1 284 ? 3.18765   30.29073 -10.47604 0.500 20.95280 ? 284 SER A OG  1 
ATOM   2198 O OG  B SER A 1 284 ? 4.12041   31.37612 -12.14188 0.500 26.02984 ? 284 SER A OG  1 
ATOM   2199 N N   . ALA A 1 285 ? 3.08195   32.05763 -7.84027  1.000 20.06694 ? 285 ALA A N   1 
ATOM   2200 C CA  . ALA A 1 285 ? 3.10377   31.62009 -6.45679  1.000 23.87529 ? 285 ALA A CA  1 
ATOM   2201 C C   . ALA A 1 285 ? 2.93384   30.11398 -6.32551  1.000 28.13472 ? 285 ALA A C   1 
ATOM   2202 O O   . ALA A 1 285 ? 3.06670   29.58876 -5.21566  1.000 25.78936 ? 285 ALA A O   1 
ATOM   2203 C CB  . ALA A 1 285 ? 2.01116   32.31915 -5.63567  1.000 25.79125 ? 285 ALA A CB  1 
ATOM   2204 N N   . LEU A 1 286 ? 2.64088   29.41536 -7.42166  1.000 22.54712 ? 286 LEU A N   1 
ATOM   2205 C CA  . LEU A 1 286 ? 2.55647   27.96365 -7.43763  1.000 18.79696 ? 286 LEU A CA  1 
ATOM   2206 C C   . LEU A 1 286 ? 3.62517   27.42238 -8.37055  1.000 21.07910 ? 286 LEU A C   1 
ATOM   2207 O O   . LEU A 1 286 ? 3.99213   28.08136 -9.34151  1.000 26.38987 ? 286 LEU A O   1 
ATOM   2208 C CB  . LEU A 1 286 ? 1.22098   27.45981 -7.93067  1.000 22.01050 ? 286 LEU A CB  1 
ATOM   2209 C CG  . LEU A 1 286 ? 0.07068   27.95845 -7.07129  1.000 28.51329 ? 286 LEU A CG  1 
ATOM   2210 C CD1 . LEU A 1 286 ? -1.27286  27.65146 -7.73271  1.000 31.55577 ? 286 LEU A CD1 1 
ATOM   2211 C CD2 . LEU A 1 286 ? 0.16930   27.35055 -5.69212  1.000 26.68728 ? 286 LEU A CD2 1 
ATOM   2212 N N   . LEU A 1 287 ? 4.09422   26.20325 -8.10874  1.000 23.87243 ? 287 LEU A N   1 
ATOM   2213 C CA  . LEU A 1 287 ? 5.10471   25.65289 -9.00377  1.000 19.23460 ? 287 LEU A CA  1 
ATOM   2214 C C   . LEU A 1 287 ? 4.45778   25.24005 -10.32306 1.000 21.47305 ? 287 LEU A C   1 
ATOM   2215 O O   . LEU A 1 287 ? 3.34564   24.70444 -10.35100 1.000 23.77519 ? 287 LEU A O   1 
ATOM   2216 C CB  . LEU A 1 287 ? 5.82710   24.47836 -8.34669  1.000 19.81493 ? 287 LEU A CB  1 
ATOM   2217 C CG  . LEU A 1 287 ? 6.39563   24.81029 -6.96107  1.000 20.89961 ? 287 LEU A CG  1 
ATOM   2218 C CD1 . LEU A 1 287 ? 7.12693   23.59964 -6.39614  1.000 24.80023 ? 287 LEU A CD1 1 
ATOM   2219 C CD2 . LEU A 1 287 ? 7.37277   25.94327 -7.07196  1.000 27.16970 ? 287 LEU A CD2 1 
ATOM   2220 N N   . GLU A 1 288 ? 5.12831   25.53717 -11.42224 1.000 20.36165 ? 288 GLU A N   1 
ATOM   2221 C CA  . GLU A 1 288 ? 4.56257   25.34442 -12.75863 1.000 17.92025 ? 288 GLU A CA  1 
ATOM   2222 C C   . GLU A 1 288 ? 5.08713   24.05676 -13.37173 1.000 19.97017 ? 288 GLU A C   1 
ATOM   2223 O O   . GLU A 1 288 ? 6.28940   23.79249 -13.33181 1.000 20.00148 ? 288 GLU A O   1 
ATOM   2224 C CB  . GLU A 1 288 ? 4.91725   26.52471 -13.67915 1.000 18.13990 ? 288 GLU A CB  1 
ATOM   2225 C CG  . GLU A 1 288 ? 4.41552   27.85647 -13.20424 1.000 27.13500 ? 288 GLU A CG  1 
ATOM   2226 C CD  . GLU A 1 288 ? 3.10533   28.26032 -13.83512 1.000 50.39847 ? 288 GLU A CD  1 
ATOM   2227 O OE1 . GLU A 1 288 ? 2.68097   27.61775 -14.83481 1.000 36.26223 ? 288 GLU A OE1 1 
ATOM   2228 O OE2 . GLU A 1 288 ? 2.51181   29.23422 -13.31880 1.000 41.34661 ? 288 GLU A OE2 1 
ATOM   2229 N N   . ASP A 1 289 ? 4.19200   23.26413 -13.97356 1.000 18.68755 ? 289 ASP A N   1 
ATOM   2230 C CA  . ASP A 1 289 ? 4.60786   21.98468 -14.53767 1.000 16.27253 ? 289 ASP A CA  1 
ATOM   2231 C C   . ASP A 1 289 ? 4.19288   21.79484 -15.99742 1.000 20.90311 ? 289 ASP A C   1 
ATOM   2232 O O   . ASP A 1 289 ? 4.20860   20.65954 -16.48773 1.000 19.34250 ? 289 ASP A O   1 
ATOM   2233 C CB  . ASP A 1 289 ? 4.10199   20.81213 -13.66611 1.000 18.95571 ? 289 ASP A CB  1 
ATOM   2234 C CG  . ASP A 1 289 ? 2.62344   20.48339 -13.89829 1.000 20.44590 ? 289 ASP A CG  1 
ATOM   2235 O OD1 . ASP A 1 289 ? 1.87351   21.32342 -14.47615 1.000 20.67326 ? 289 ASP A OD1 1 
ATOM   2236 O OD2 . ASP A 1 289 ? 2.20411   19.37123 -13.50748 1.000 22.20640 ? 289 ASP A OD2 1 
ATOM   2237 N N   . GLU A 1 290 ? 3.92930   22.87104 -16.73947 1.000 18.72016 ? 290 GLU A N   1 
ATOM   2238 C CA  . GLU A 1 290 ? 3.62506   22.74184 -18.16501 1.000 17.46686 ? 290 GLU A CA  1 
ATOM   2239 C C   . GLU A 1 290 ? 4.69399   23.36864 -19.07863 1.000 20.77383 ? 290 GLU A C   1 
ATOM   2240 O O   . GLU A 1 290 ? 4.39849   23.75010 -20.22277 1.000 20.44975 ? 290 GLU A O   1 
ATOM   2241 C CB  . GLU A 1 290 ? 2.22008   23.27719 -18.45625 1.000 22.86803 ? 290 GLU A CB  1 
ATOM   2242 C CG  . GLU A 1 290 ? 1.14243   22.36004 -17.76256 1.000 22.11191 ? 290 GLU A CG  1 
ATOM   2243 C CD  . GLU A 1 290 ? -0.26362  22.39161 -18.36099 1.000 26.09910 ? 290 GLU A CD  1 
ATOM   2244 O OE1 . GLU A 1 290 ? -0.56235  23.18414 -19.28188 1.000 21.13264 ? 290 GLU A OE1 1 
ATOM   2245 O OE2 . GLU A 1 290 ? -1.08911  21.59993 -17.87669 1.000 25.58011 ? 290 GLU A OE2 1 
ATOM   2246 N N   . PHE A 1 291 ? 5.96134   23.36731 -18.64272 1.000 18.15969 ? 291 PHE A N   1 
ATOM   2247 C CA  . PHE A 1 291 ? 7.12314   23.54879 -19.53320 1.000 17.29179 ? 291 PHE A CA  1 
ATOM   2248 C C   . PHE A 1 291 ? 7.97945   22.28699 -19.50074 1.000 19.44189 ? 291 PHE A C   1 
ATOM   2249 O O   . PHE A 1 291 ? 8.48139   21.91197 -18.42971 1.000 17.97436 ? 291 PHE A O   1 
ATOM   2250 C CB  . PHE A 1 291 ? 8.00675   24.71889 -19.09092 1.000 22.04530 ? 291 PHE A CB  1 
ATOM   2251 C CG  . PHE A 1 291 ? 7.32325   26.04997 -19.12100 1.000 18.87447 ? 291 PHE A CG  1 
ATOM   2252 C CD1 . PHE A 1 291 ? 7.27076   26.78999 -20.31242 1.000 20.56241 ? 291 PHE A CD1 1 
ATOM   2253 C CD2 . PHE A 1 291 ? 6.77508   26.58557 -17.98735 1.000 20.68757 ? 291 PHE A CD2 1 
ATOM   2254 C CE1 . PHE A 1 291 ? 6.66737   28.02331 -20.34022 1.000 24.19787 ? 291 PHE A CE1 1 
ATOM   2255 C CE2 . PHE A 1 291 ? 6.13502   27.83229 -18.01562 1.000 28.31639 ? 291 PHE A CE2 1 
ATOM   2256 C CZ  . PHE A 1 291 ? 6.09382   28.54606 -19.20079 1.000 22.20363 ? 291 PHE A CZ  1 
ATOM   2257 N N   . THR A 1 292 ? 8.23902   21.68504 -20.67391 1.000 16.31067 ? 292 THR A N   1 
ATOM   2258 C CA  . THR A 1 292 ? 9.18443   20.57530 -20.69351 1.000 16.52296 ? 292 THR A CA  1 
ATOM   2259 C C   . THR A 1 292 ? 10.61094  21.10251 -20.70043 1.000 17.50103 ? 292 THR A C   1 
ATOM   2260 O O   . THR A 1 292 ? 10.86643  22.27627 -20.96887 1.000 18.00266 ? 292 THR A O   1 
ATOM   2261 C CB  . THR A 1 292 ? 8.99191   19.70361 -21.93038 1.000 16.82077 ? 292 THR A CB  1 
ATOM   2262 O OG1 . THR A 1 292 ? 9.36334   20.47522 -23.08118 1.000 19.90844 ? 292 THR A OG1 1 
ATOM   2263 C CG2 . THR A 1 292 ? 7.54477   19.28557 -22.08074 1.000 19.34021 ? 292 THR A CG2 1 
ATOM   2264 N N   . PRO A 1 293 ? 11.59493  20.24668 -20.43210 1.000 17.61442 ? 293 PRO A N   1 
ATOM   2265 C CA  . PRO A 1 293 ? 12.97956  20.67617 -20.61350 1.000 17.98318 ? 293 PRO A CA  1 
ATOM   2266 C C   . PRO A 1 293 ? 13.23961  21.23412 -22.00063 1.000 18.90352 ? 293 PRO A C   1 
ATOM   2267 O O   . PRO A 1 293 ? 13.98284  22.20876 -22.12949 1.000 20.59501 ? 293 PRO A O   1 
ATOM   2268 C CB  . PRO A 1 293 ? 13.77541  19.38981 -20.35574 1.000 22.23894 ? 293 PRO A CB  1 
ATOM   2269 C CG  . PRO A 1 293 ? 12.91677  18.64393 -19.37708 1.000 18.18163 ? 293 PRO A CG  1 
ATOM   2270 C CD  . PRO A 1 293 ? 11.50541  18.88703 -19.88138 1.000 20.04527 ? 293 PRO A CD  1 
ATOM   2271 N N   . PHE A 1 294 ? 12.64192  20.64406 -23.04604 1.000 18.72557 ? 294 PHE A N   1 
ATOM   2272 C CA  . PHE A 1 294 ? 12.89089  21.15480 -24.39552 1.000 21.20918 ? 294 PHE A CA  1 
ATOM   2273 C C   . PHE A 1 294 ? 12.28793  22.54299 -24.58940 1.000 22.79632 ? 294 PHE A C   1 
ATOM   2274 O O   . PHE A 1 294 ? 12.91012  23.41402 -25.21454 1.000 23.41819 ? 294 PHE A O   1 
ATOM   2275 C CB  . PHE A 1 294 ? 12.34330  20.17110 -25.42718 1.000 26.72519 ? 294 PHE A CB  1 
ATOM   2276 C CG  . PHE A 1 294 ? 12.91095  20.38239 -26.81875 1.000 55.16481 ? 294 PHE A CG  1 
ATOM   2277 C CD1 . PHE A 1 294 ? 14.03430  21.18935 -27.00765 1.000 52.83576 ? 294 PHE A CD1 1 
ATOM   2278 C CD2 . PHE A 1 294 ? 12.32475  19.79447 -27.93143 1.000 58.86030 ? 294 PHE A CD2 1 
ATOM   2279 C CE1 . PHE A 1 294 ? 14.56084  21.39217 -28.27339 1.000 51.61303 ? 294 PHE A CE1 1 
ATOM   2280 C CE2 . PHE A 1 294 ? 12.85409  20.00000 -29.20251 1.000 54.49212 ? 294 PHE A CE2 1 
ATOM   2281 C CZ  . PHE A 1 294 ? 13.96696  20.79838 -29.36628 1.000 55.42777 ? 294 PHE A CZ  1 
ATOM   2282 N N   . ASP A 1 295 ? 11.09619  22.77969 -24.03619 1.000 19.01472 ? 295 ASP A N   1 
ATOM   2283 C CA  . ASP A 1 295 ? 10.48305  24.11676 -24.09895 1.000 21.17599 ? 295 ASP A CA  1 
ATOM   2284 C C   . ASP A 1 295 ? 11.38891  25.16303 -23.46982 1.000 18.73591 ? 295 ASP A C   1 
ATOM   2285 O O   . ASP A 1 295 ? 11.52280  26.27541 -23.97279 1.000 20.79088 ? 295 ASP A O   1 
ATOM   2286 C CB  . ASP A 1 295 ? 9.13545   24.18012 -23.35320 1.000 19.48454 ? 295 ASP A CB  1 
ATOM   2287 C CG  . ASP A 1 295 ? 8.07575   23.27909 -23.92639 1.000 24.99423 ? 295 ASP A CG  1 
ATOM   2288 O OD1 . ASP A 1 295 ? 8.14395   22.94429 -25.13645 1.000 25.67409 ? 295 ASP A OD1 1 
ATOM   2289 O OD2 . ASP A 1 295 ? 7.14387   22.90859 -23.16063 1.000 22.08968 ? 295 ASP A OD2 1 
ATOM   2290 N N   . VAL A 1 296 ? 11.96846  24.85477 -22.31749 1.000 17.45317 ? 296 VAL A N   1 
ATOM   2291 C CA  . VAL A 1 296 ? 12.82015  25.82733 -21.64790 1.000 19.56457 ? 296 VAL A CA  1 
ATOM   2292 C C   . VAL A 1 296 ? 14.04661  26.14841 -22.50227 1.000 21.62767 ? 296 VAL A C   1 
ATOM   2293 O O   . VAL A 1 296 ? 14.40780  27.31368 -22.70553 1.000 23.80509 ? 296 VAL A O   1 
ATOM   2294 C CB  . VAL A 1 296 ? 13.20936  25.31093 -20.25218 1.000 19.70702 ? 296 VAL A CB  1 
ATOM   2295 C CG1 . VAL A 1 296 ? 14.25665  26.24105 -19.63149 1.000 19.13661 ? 296 VAL A CG1 1 
ATOM   2296 C CG2 . VAL A 1 296 ? 11.99688  25.18232 -19.36465 1.000 19.79563 ? 296 VAL A CG2 1 
ATOM   2297 N N   . VAL A 1 297 ? 14.70230  25.12603 -23.01864 1.000 20.68065 ? 297 VAL A N   1 
ATOM   2298 C CA  . VAL A 1 297 ? 15.88919  25.38195 -23.83581 1.000 23.18619 ? 297 VAL A CA  1 
ATOM   2299 C C   . VAL A 1 297 ? 15.50936  26.18384 -25.07445 1.000 23.66877 ? 297 VAL A C   1 
ATOM   2300 O O   . VAL A 1 297 ? 16.20141  27.13917 -25.46086 1.000 26.68192 ? 297 VAL A O   1 
ATOM   2301 C CB  . VAL A 1 297 ? 16.55792  24.05628 -24.21681 1.000 24.49302 ? 297 VAL A CB  1 
ATOM   2302 C CG1 . VAL A 1 297 ? 17.55383  24.30375 -25.37316 1.000 26.05889 ? 297 VAL A CG1 1 
ATOM   2303 C CG2 . VAL A 1 297 ? 17.22753  23.44687 -22.99400 1.000 22.72829 ? 297 VAL A CG2 1 
ATOM   2304 N N   . ARG A 1 298 ? 14.40231  25.81561 -25.71255 1.000 24.91805 ? 298 ARG A N   1 
ATOM   2305 C CA  . ARG A 1 298 ? 13.97671  26.51088 -26.92586 1.000 22.28793 ? 298 ARG A CA  1 
ATOM   2306 C C   . ARG A 1 298 ? 13.70876  27.98066 -26.62887 1.000 27.36909 ? 298 ARG A C   1 
ATOM   2307 O O   . ARG A 1 298 ? 14.17181  28.86654 -27.35234 1.000 28.00361 ? 298 ARG A O   1 
ATOM   2308 C CB  . ARG A 1 298 ? 12.73411  25.84045 -27.51566 1.000 25.22827 ? 298 ARG A CB  1 
ATOM   2309 C CG  . ARG A 1 298 ? 12.30913  26.38678 -28.82889 1.000 42.08542 ? 298 ARG A CG  1 
ATOM   2310 C CD  . ARG A 1 298 ? 11.01375  25.75012 -29.32690 1.000 42.13645 ? 298 ARG A CD  1 
ATOM   2311 N NE  . ARG A 1 298 ? 10.95801  24.31034 -29.11412 1.000 50.00464 ? 298 ARG A NE  1 
ATOM   2312 C CZ  . ARG A 1 298 ? 10.13065  23.71928 -28.26324 1.000 46.70274 ? 298 ARG A CZ  1 
ATOM   2313 N NH1 . ARG A 1 298 ? 9.24941   24.41532 -27.55699 1.000 41.71167 ? 298 ARG A NH1 1 
ATOM   2314 N NH2 . ARG A 1 298 ? 10.17690  22.39647 -28.12769 1.000 57.42077 ? 298 ARG A NH2 1 
ATOM   2315 N N   . GLN A 1 299 ? 12.96499  28.25988 -25.55468 1.000 25.58517 ? 299 GLN A N   1 
ATOM   2316 C CA  . GLN A 1 299 ? 12.61787  29.64509 -25.25826 1.000 23.56406 ? 299 GLN A CA  1 
ATOM   2317 C C   . GLN A 1 299 ? 13.84062  30.43787 -24.79678 1.000 24.35157 ? 299 GLN A C   1 
ATOM   2318 O O   . GLN A 1 299 ? 14.03643  31.58557 -25.21418 1.000 29.46042 ? 299 GLN A O   1 
ATOM   2319 C CB  . GLN A 1 299 ? 11.50148  29.71044 -24.20489 1.000 22.08512 ? 299 GLN A CB  1 
ATOM   2320 C CG  . GLN A 1 299 ? 11.25381  31.12487 -23.77448 1.000 21.08956 ? 299 GLN A CG  1 
ATOM   2321 C CD  . GLN A 1 299 ? 9.95196   31.34216 -22.99454 1.000 20.39934 ? 299 GLN A CD  1 
ATOM   2322 O OE1 . GLN A 1 299 ? 9.73513   32.42878 -22.46544 1.000 23.98947 ? 299 GLN A OE1 1 
ATOM   2323 N NE2 . GLN A 1 299 ? 9.12413   30.29825 -22.86572 1.000 21.91607 ? 299 GLN A NE2 1 
ATOM   2324 N N   . CYS A 1 300 ? 14.69976  29.83898 -23.98422 1.000 22.19757 ? 300 CYS A N   1 
ATOM   2325 C CA  . CYS A 1 300 ? 15.84584  30.59005 -23.50785 1.000 25.99071 ? 300 CYS A CA  1 
ATOM   2326 C C   . CYS A 1 300 ? 16.97125  30.70627 -24.53830 1.000 30.27074 ? 300 CYS A C   1 
ATOM   2327 O O   . CYS A 1 300 ? 17.84626  31.55633 -24.36349 1.000 29.26392 ? 300 CYS A O   1 
ATOM   2328 C CB  . CYS A 1 300 ? 16.37070  29.96421 -22.22362 1.000 28.53085 ? 300 CYS A CB  1 
ATOM   2329 S SG  . CYS A 1 300 ? 15.21253  30.05119 -20.81509 1.000 31.72326 ? 300 CYS A SG  1 
ATOM   2330 N N   . SER A 1 301 ? 16.96280  29.91632 -25.61965 1.000 31.01711 ? 301 SER A N   1 
ATOM   2331 C CA  . SER A 1 301 ? 17.97354  30.05974 -26.66875 1.000 28.95409 ? 301 SER A CA  1 
ATOM   2332 C C   . SER A 1 301 ? 17.46301  30.68342 -27.96675 1.000 35.34650 ? 301 SER A C   1 
ATOM   2333 O O   . SER A 1 301 ? 18.27566  30.92230 -28.86949 1.000 33.34723 ? 301 SER A O   1 
ATOM   2334 C CB  . SER A 1 301 ? 18.59698  28.69636 -26.99515 1.000 32.78940 ? 301 SER A CB  1 
ATOM   2335 O OG  . SER A 1 301 ? 17.69793  27.92282 -27.76793 1.000 35.76067 ? 301 SER A OG  1 
ATOM   2336 N N   . GLY A 1 302 ? 16.16268  30.94222 -28.10282 1.000 28.05133 ? 302 GLY A N   1 
ATOM   2337 C CA  . GLY A 1 302 ? 15.65188  31.60620 -29.30581 1.000 28.16222 ? 302 GLY A CA  1 
ATOM   2338 C C   . GLY A 1 302 ? 15.53300  30.72491 -30.53574 1.000 33.39443 ? 302 GLY A C   1 
ATOM   2339 O O   . GLY A 1 302 ? 15.73134  31.20526 -31.67138 1.000 27.00215 ? 302 GLY A O   1 
ATOM   2340 N N   . VAL A 1 303 ? 15.19341  29.44465 -30.34996 1.000 27.84803 ? 303 VAL A N   1 
ATOM   2341 C CA  . VAL A 1 303 ? 15.01617  28.53238 -31.48070 1.000 32.14245 ? 303 VAL A CA  1 
ATOM   2342 C C   . VAL A 1 303 ? 13.84323  28.98755 -32.34877 1.000 35.36496 ? 303 VAL A C   1 
ATOM   2343 O O   . VAL A 1 303 ? 12.76913  29.33169 -31.83980 1.000 29.89550 ? 303 VAL A O   1 
ATOM   2344 C CB  . VAL A 1 303 ? 14.79789  27.10154 -30.95712 1.000 30.78035 ? 303 VAL A CB  1 
ATOM   2345 C CG1 . VAL A 1 303 ? 14.24678  26.21285 -32.03455 1.000 29.56476 ? 303 VAL A CG1 1 
ATOM   2346 C CG2 . VAL A 1 303 ? 16.08134  26.52192 -30.36316 1.000 28.12263 ? 303 VAL A CG2 1 
ATOM   2347 N N   . THR A 1 304 ? 14.03566  28.99193 -33.66999 1.000 25.63547 ? 304 THR A N   1 
ATOM   2348 C CA  . THR A 1 304 ? 13.00267  29.45978 -34.59770 1.000 28.73202 ? 304 THR A CA  1 
ATOM   2349 C C   . THR A 1 304 ? 12.54551  28.34111 -35.53122 1.000 34.54339 ? 304 THR A C   1 
ATOM   2350 O O   . THR A 1 304 ? 13.14806  27.26458 -35.60433 1.000 33.18956 ? 304 THR A O   1 
ATOM   2351 C CB  . THR A 1 304 ? 13.49835  30.64573 -35.43307 1.000 29.61184 ? 304 THR A CB  1 
ATOM   2352 O OG1 . THR A 1 304 ? 14.67796  30.24703 -36.14464 1.000 33.22001 ? 304 THR A OG1 1 
ATOM   2353 C CG2 . THR A 1 304 ? 13.82185  31.82979 -34.53856 1.000 22.57558 ? 304 THR A CG2 1 
ATOM   2354 N N   . PHE A 1 305 ? 11.46438  28.61408 -36.26573 1.000 33.74633 ? 307 PHE A N   1 
ATOM   2355 C CA  . PHE A 1 305 ? 10.86785  27.61825 -37.15439 1.000 31.60157 ? 307 PHE A CA  1 
ATOM   2356 C C   . PHE A 1 305 ? 10.70247  28.17735 -38.55518 1.000 41.35810 ? 307 PHE A C   1 
ATOM   2357 O O   . PHE A 1 305 ? 10.87661  29.37243 -38.74867 1.000 42.52330 ? 307 PHE A O   1 
ATOM   2358 C CB  . PHE A 1 305 ? 9.52258   27.15009 -36.58624 1.000 32.96424 ? 307 PHE A CB  1 
ATOM   2359 C CG  . PHE A 1 305 ? 9.61582   26.75910 -35.13475 1.000 35.87619 ? 307 PHE A CG  1 
ATOM   2360 C CD1 . PHE A 1 305 ? 10.10296  25.50969 -34.77446 1.000 39.39975 ? 307 PHE A CD1 1 
ATOM   2361 C CD2 . PHE A 1 305 ? 9.27842   27.66076 -34.13389 1.000 38.10396 ? 307 PHE A CD2 1 
ATOM   2362 C CE1 . PHE A 1 305 ? 10.22476  25.15561 -33.43648 1.000 40.01739 ? 307 PHE A CE1 1 
ATOM   2363 C CE2 . PHE A 1 305 ? 9.41361   27.30954 -32.78653 1.000 36.07867 ? 307 PHE A CE2 1 
ATOM   2364 C CZ  . PHE A 1 305 ? 9.87851   26.05557 -32.45116 1.000 36.10082 ? 307 PHE A CZ  1 
HETATM 2365 C C8  . 4WI B 2 .   ? -16.13831 21.18547 -25.35585 1.000 23.17164 ? 401 4WI A C8  1 
HETATM 2366 C C3  . 4WI B 2 .   ? -17.55334 19.62967 -29.78295 1.000 33.73845 ? 401 4WI A C3  1 
HETATM 2367 C C1  . 4WI B 2 .   ? -19.16753 17.61171 -27.38608 1.000 23.14102 ? 401 4WI A C1  1 
HETATM 2368 C C13 . 4WI B 2 .   ? -19.26993 16.44583 -24.67849 1.000 24.29977 ? 401 4WI A C13 1 
HETATM 2369 C C21 . 4WI B 2 .   ? -19.24607 14.24831 -22.16305 1.000 29.91526 ? 401 4WI A C21 1 
HETATM 2370 C C6  . 4WI B 2 .   ? -18.51566 21.14970 -25.77015 1.000 24.40533 ? 401 4WI A C6  1 
HETATM 2371 C C7  . 4WI B 2 .   ? -18.20901 22.07951 -24.60385 1.000 24.84897 ? 401 4WI A C7  1 
HETATM 2372 C C10 . 4WI B 2 .   ? -21.04056 15.07202 -26.06156 1.000 24.69566 ? 401 4WI A C10 1 
HETATM 2373 C C5  . 4WI B 2 .   ? -17.23236 20.34923 -26.02205 1.000 22.95410 ? 401 4WI A C5  1 
HETATM 2374 C C9  . 4WI B 2 .   ? -19.08560 16.13494 -27.07851 1.000 23.47969 ? 401 4WI A C9  1 
HETATM 2375 C C11 . 4WI B 2 .   ? -21.04108 14.79495 -27.53893 1.000 21.50285 ? 401 4WI A C11 1 
HETATM 2376 C C12 . 4WI B 2 .   ? -19.82484 15.39012 -28.19589 1.000 22.08590 ? 401 4WI A C12 1 
HETATM 2377 C C18 . 4WI B 2 .   ? -19.90944 13.87969 -27.94758 1.000 25.67384 ? 401 4WI A C18 1 
HETATM 2378 C C19 . 4WI B 2 .   ? -20.24566 12.95057 -29.08658 1.000 27.08897 ? 401 4WI A C19 1 
HETATM 2379 C C20 . 4WI B 2 .   ? -19.23043 13.13626 -26.83929 1.000 24.60867 ? 401 4WI A C20 1 
HETATM 2380 C C16 . 4WI B 2 .   ? -19.39705 18.55704 -22.45797 1.000 23.87258 ? 401 4WI A C16 1 
HETATM 2381 C C17 . 4WI B 2 .   ? -21.27844 17.13194 -21.55754 1.000 25.11275 ? 401 4WI A C17 1 
HETATM 2382 C C23 . 4WI B 2 .   ? -21.46800 18.16243 -23.80844 1.000 21.92972 ? 401 4WI A C23 1 
HETATM 2383 C C4  . 4WI B 2 .   ? -16.91201 20.30681 -27.50548 1.000 25.35975 ? 401 4WI A C4  1 
HETATM 2384 C C2  . 4WI B 2 .   ? -17.96311 19.57558 -28.31941 1.000 25.07844 ? 401 4WI A C2  1 
HETATM 2385 C C14 . 4WI B 2 .   ? -20.00291 16.24895 -23.37762 1.000 17.95049 ? 401 4WI A C14 1 
HETATM 2386 C C22 . 4WI B 2 .   ? -18.18213 13.66500 -21.28637 1.000 36.04459 ? 401 4WI A C22 1 
HETATM 2387 C C15 . 4WI B 2 .   ? -20.50556 17.54982 -22.80600 1.000 24.97771 ? 401 4WI A C15 1 
HETATM 2388 N N5  . 4WI B 2 .   ? -17.50041 20.65489 -30.34579 1.000 21.11200 ? 401 4WI A N5  1 
HETATM 2389 N N2  . 4WI B 2 .   ? -16.75113 22.11791 -24.61604 1.000 26.08774 ? 401 4WI A N2  1 
HETATM 2390 N N3  . 4WI B 2 .   ? -19.80233 15.91383 -25.81211 1.000 21.50048 ? 401 4WI A N3  1 
HETATM 2391 N N1  . 4WI B 2 .   ? -18.08830 18.16925 -27.95659 1.000 23.64420 ? 401 4WI A N1  1 
HETATM 2392 N N4  . 4WI B 2 .   ? -19.08917 15.52933 -22.50378 1.000 20.10255 ? 401 4WI A N4  1 
HETATM 2393 O O1  . 4WI B 2 .   ? -14.92797 21.02201 -25.45135 1.000 23.49632 ? 401 4WI A O1  1 
HETATM 2394 O O2  . 4WI B 2 .   ? -20.18786 18.28106 -27.19514 1.000 23.68658 ? 401 4WI A O2  1 
HETATM 2395 O O3  . 4WI B 2 .   ? -18.19632 17.09413 -24.70398 1.000 22.04579 ? 401 4WI A O3  1 
HETATM 2396 O O4  . 4WI B 2 .   ? -20.19078 13.59565 -22.57641 1.000 33.51753 ? 401 4WI A O4  1 
HETATM 2397 F F1  . 4WI B 2 .   ? -16.96954 13.91479 -21.75878 1.000 34.51733 ? 401 4WI A F1  1 
HETATM 2398 F F2  . 4WI B 2 .   ? -18.41200 12.35531 -21.30475 1.000 37.64759 ? 401 4WI A F2  1 
HETATM 2399 F F3  . 4WI B 2 .   ? -18.22064 14.16321 -20.07133 1.000 36.00738 ? 401 4WI A F3  1 
HETATM 2400 H H5  . 4WI B 2 .   ? -19.32865 20.47449 -25.50325 1.000 29.29993 ? 401 4WI A H5  1 
HETATM 2401 H H6  . 4WI B 2 .   ? -18.76893 21.73416 -26.65467 1.000 29.29993 ? 401 4WI A H6  1 
HETATM 2402 H H7  . 4WI B 2 .   ? -18.57609 21.65971 -23.67080 1.000 29.83230 ? 401 4WI A H7  1 
HETATM 2403 H H8  . 4WI B 2 .   ? -18.62251 23.06887 -24.78202 1.000 29.83230 ? 401 4WI A H8  1 
HETATM 2404 H H11 . 4WI B 2 .   ? -22.01355 15.38293 -25.67826 1.000 29.64833 ? 401 4WI A H11 1 
HETATM 2405 H H12 . 4WI B 2 .   ? -21.24706 14.18923 -25.45466 1.000 29.64833 ? 401 4WI A H12 1 
HETATM 2406 H H10 . 4WI B 2 .   ? -18.08749 15.70788 -26.99302 1.000 28.18916 ? 401 4WI A H10 1 
HETATM 2407 H H14 . 4WI B 2 .   ? -19.69595 15.57041 -29.26312 1.000 26.51661 ? 401 4WI A H14 1 
HETATM 2408 H H23 . 4WI B 2 .   ? -19.32925 12.59785 -29.55278 1.000 32.52030 ? 401 4WI A H23 1 
HETATM 2409 H H24 . 4WI B 2 .   ? -20.80796 12.09990 -28.71010 1.000 32.52030 ? 401 4WI A H24 1 
HETATM 2410 H H25 . 4WI B 2 .   ? -20.84403 13.47894 -29.82438 1.000 32.52030 ? 401 4WI A H25 1 
HETATM 2411 H H26 . 4WI B 2 .   ? -19.30190 13.71686 -25.91720 1.000 29.54394 ? 401 4WI A H26 1 
HETATM 2412 H H27 . 4WI B 2 .   ? -19.71723 12.16855 -26.70133 1.000 29.54394 ? 401 4WI A H27 1 
HETATM 2413 H H28 . 4WI B 2 .   ? -18.17992 12.98443 -27.09590 1.000 29.54394 ? 401 4WI A H28 1 
HETATM 2414 H H17 . 4WI B 2 .   ? -18.42572 18.10472 -22.64683 1.000 28.66063 ? 401 4WI A H17 1 
HETATM 2415 H H19 . 4WI B 2 .   ? -19.47364 18.82980 -21.40750 1.000 28.66063 ? 401 4WI A H19 1 
HETATM 2416 H H18 . 4WI B 2 .   ? -19.51059 19.44641 -23.07431 1.000 28.66063 ? 401 4WI A H18 1 
HETATM 2417 H H20 . 4WI B 2 .   ? -20.58693 16.74250 -20.81329 1.000 30.14883 ? 401 4WI A H20 1 
HETATM 2418 H H21 . 4WI B 2 .   ? -21.80210 17.99277 -21.14707 1.000 30.14883 ? 401 4WI A H21 1 
HETATM 2419 H H22 . 4WI B 2 .   ? -22.00086 16.36068 -21.81641 1.000 30.14883 ? 401 4WI A H22 1 
HETATM 2420 H H29 . 4WI B 2 .   ? -21.99581 18.99534 -23.34392 1.000 26.32920 ? 401 4WI A H29 1 
HETATM 2421 H H30 . 4WI B 2 .   ? -20.91158 18.52277 -24.67368 1.000 26.32920 ? 401 4WI A H30 1 
HETATM 2422 H H31 . 4WI B 2 .   ? -22.18836 17.40947 -24.12820 1.000 26.32920 ? 401 4WI A H31 1 
HETATM 2423 H H2  . 4WI B 2 .   ? -16.83687 21.32919 -27.87590 1.000 30.44523 ? 401 4WI A H2  1 
HETATM 2424 H H3  . 4WI B 2 .   ? -15.95562 19.80204 -27.64192 1.000 30.44523 ? 401 4WI A H3  1 
HETATM 2425 H H32 . 4WI B 2 .   ? -18.91541 20.06500 -28.12621 1.000 30.10766 ? 401 4WI A H32 1 
HETATM 2426 H H15 . 4WI B 2 .   ? -20.91375 15.66854 -23.51693 1.000 21.55413 ? 401 4WI A H15 1 
HETATM 2427 H H9  . 4WI B 2 .   ? -16.23479 22.80763 -24.09670 1.000 31.31882 ? 401 4WI A H9  1 
HETATM 2428 H H1  . 4WI B 2 .   ? -17.77449 17.59545 -28.71572 1.000 28.38657 ? 401 4WI A H1  1 
HETATM 2429 H H16 . 4WI B 2 .   ? -18.29448 16.02404 -22.13533 1.000 24.13659 ? 401 4WI A H16 1 
HETATM 2430 O O   . HOH C 3 .   ? 2.88734   25.78209 -16.19637 1.000 26.99315 ? 501 HOH A O   1 
HETATM 2431 O O   . HOH C 3 .   ? -26.83376 9.07249  -50.66304 1.000 33.15827 ? 502 HOH A O   1 
HETATM 2432 O O   . HOH C 3 .   ? 20.83015  24.51115 -22.30301 1.000 42.04194 ? 503 HOH A O   1 
HETATM 2433 O O   . HOH C 3 .   ? -24.68433 23.45436 -38.41118 1.000 52.94870 ? 504 HOH A O   1 
HETATM 2434 O O   . HOH C 3 .   ? 2.71785   9.73652  -16.75312 1.000 45.03699 ? 505 HOH A O   1 
HETATM 2435 O O   . HOH C 3 .   ? -16.83262 20.66512 -17.76955 1.000 40.00941 ? 506 HOH A O   1 
HETATM 2436 O O   . HOH C 3 .   ? 3.61821   21.83755 -6.07553  1.000 36.72743 ? 507 HOH A O   1 
HETATM 2437 O O   . HOH C 3 .   ? 0.43697   25.15782 -20.31512 1.000 30.38929 ? 508 HOH A O   1 
HETATM 2438 O O   . HOH C 3 .   ? -23.789   7.088    -18.191   1.000 42.24892 ? 509 HOH A O   1 
HETATM 2439 O O   . HOH C 3 .   ? -2.82872  5.77666  -32.68957 1.000 35.56358 ? 510 HOH A O   1 
HETATM 2440 O O   . HOH C 3 .   ? -11.88407 28.19735 -27.47679 1.000 25.97310 ? 511 HOH A O   1 
HETATM 2441 O O   . HOH C 3 .   ? 3.94505   32.18165 -2.52436  1.000 35.56993 ? 512 HOH A O   1 
HETATM 2442 O O   . HOH C 3 .   ? -13.87908 20.64325 -57.40277 1.000 52.40277 ? 513 HOH A O   1 
HETATM 2443 O O   . HOH C 3 .   ? -20.57494 5.35788  -46.10957 1.000 39.73316 ? 514 HOH A O   1 
HETATM 2444 O O   . HOH C 3 .   ? -18.26916 20.17056 -49.92890 1.000 30.59321 ? 515 HOH A O   1 
HETATM 2445 O O   . HOH C 3 .   ? -28.03623 4.47753  -35.66946 1.000 42.19594 ? 516 HOH A O   1 
HETATM 2446 O O   . HOH C 3 .   ? -9.92561  29.29940 -41.53765 1.000 37.60370 ? 517 HOH A O   1 
HETATM 2447 O O   . HOH C 3 .   ? -7.73551  9.45867  -16.79093 1.000 32.19844 ? 518 HOH A O   1 
HETATM 2448 O O   . HOH C 3 .   ? 12.41700  19.80449 -44.79332 1.000 47.57265 ? 519 HOH A O   1 
HETATM 2449 O O   . HOH C 3 .   ? -2.45944  10.77187 -12.72499 1.000 42.80542 ? 520 HOH A O   1 
HETATM 2450 O O   . HOH C 3 .   ? -19.29982 20.39389 -13.54561 1.000 38.39571 ? 521 HOH A O   1 
HETATM 2451 O O   . HOH C 3 .   ? 26.61038  22.93509 -0.83648  1.000 33.57032 ? 522 HOH A O   1 
HETATM 2452 O O   . HOH C 3 .   ? -7.79155  13.64878 -54.62446 1.000 29.87637 ? 523 HOH A O   1 
HETATM 2453 O O   . HOH C 3 .   ? 19.32246  37.53860 -9.56163  1.000 33.15971 ? 524 HOH A O   1 
HETATM 2454 O O   . HOH C 3 .   ? 22.21853  12.27001 -17.28322 1.000 49.98736 ? 525 HOH A O   1 
HETATM 2455 O O   . HOH C 3 .   ? -4.70058  7.99100  -43.23722 1.000 50.92712 ? 526 HOH A O   1 
HETATM 2456 O O   . HOH C 3 .   ? 14.36416  25.33899 -1.70851  1.000 26.10693 ? 527 HOH A O   1 
HETATM 2457 O O   . HOH C 3 .   ? -1.35352  11.80950 -34.23432 1.000 25.32250 ? 528 HOH A O   1 
HETATM 2458 O O   . HOH C 3 .   ? 5.21310   9.58061  -6.99710  1.000 32.01117 ? 529 HOH A O   1 
HETATM 2459 O O   . HOH C 3 .   ? 12.00686  18.85719 -40.92865 1.000 38.16953 ? 530 HOH A O   1 
HETATM 2460 O O   . HOH C 3 .   ? -6.90256  23.66595 -34.92171 1.000 24.34336 ? 531 HOH A O   1 
HETATM 2461 O O   . HOH C 3 .   ? -6.14368  9.83787  -55.68814 1.000 45.25742 ? 532 HOH A O   1 
HETATM 2462 O O   . HOH C 3 .   ? -29.03105 10.35997 -37.37706 1.000 43.20989 ? 533 HOH A O   1 
HETATM 2463 O O   . HOH C 3 .   ? -16.04679 2.39284  -33.92389 1.000 44.53067 ? 534 HOH A O   1 
HETATM 2464 O O   . HOH C 3 .   ? 19.32790  11.61516 0.16146   1.000 34.88776 ? 535 HOH A O   1 
HETATM 2465 O O   . HOH C 3 .   ? -4.74161  10.85786 -53.78085 1.000 46.90797 ? 536 HOH A O   1 
HETATM 2466 O O   . HOH C 3 .   ? 25.36033  21.43731 -8.49821  1.000 30.31899 ? 537 HOH A O   1 
HETATM 2467 O O   . HOH C 3 .   ? 5.29061   24.78396 -22.79333 1.000 22.47354 ? 538 HOH A O   1 
HETATM 2468 O O   . HOH C 3 .   ? -25.90422 8.65225  -22.13487 1.000 34.23950 ? 539 HOH A O   1 
HETATM 2469 O O   . HOH C 3 .   ? -13.21035 29.07134 -24.56473 1.000 26.46366 ? 540 HOH A O   1 
HETATM 2470 O O   . HOH C 3 .   ? -27.00249 11.20325 -38.51553 1.000 44.93212 ? 541 HOH A O   1 
HETATM 2471 O O   . HOH C 3 .   ? -19.38767 15.03398 -53.39344 1.000 33.32111 ? 542 HOH A O   1 
HETATM 2472 O O   . HOH C 3 .   ? 6.59019   23.14657 -43.93758 1.000 31.24329 ? 543 HOH A O   1 
HETATM 2473 O O   . HOH C 3 .   ? -19.08965 23.33900 -43.88858 1.000 30.78122 ? 544 HOH A O   1 
HETATM 2474 O O   . HOH C 3 .   ? 7.74311   18.15157 -35.94163 1.000 31.16805 ? 545 HOH A O   1 
HETATM 2475 O O   . HOH C 3 .   ? 0.92962   18.13757 -6.52646  1.000 33.59685 ? 546 HOH A O   1 
HETATM 2476 O O   . HOH C 3 .   ? 5.69365   22.11508 -26.88467 1.000 28.52634 ? 547 HOH A O   1 
HETATM 2477 O O   . HOH C 3 .   ? -0.20529  26.28262 -43.92192 1.000 26.11541 ? 548 HOH A O   1 
HETATM 2478 O O   . HOH C 3 .   ? 7.33429   8.92618  -13.75415 1.000 33.66471 ? 549 HOH A O   1 
HETATM 2479 O O   . HOH C 3 .   ? 7.85654   9.16069  -6.34368  1.000 44.89505 ? 550 HOH A O   1 
HETATM 2480 O O   . HOH C 3 .   ? -17.43506 24.54478 -35.49653 1.000 26.55258 ? 551 HOH A O   1 
HETATM 2481 O O   . HOH C 3 .   ? 8.54055   19.93199 -25.59868 1.000 29.94436 ? 552 HOH A O   1 
HETATM 2482 O O   . HOH C 3 .   ? -3.00732  20.78594 -19.89739 1.000 21.06097 ? 553 HOH A O   1 
HETATM 2483 O O   . HOH C 3 .   ? 20.19607  22.54299 -4.05343  1.000 31.71434 ? 554 HOH A O   1 
HETATM 2484 O O   . HOH C 3 .   ? 23.39179  21.89854 -3.78620  1.000 43.37700 ? 555 HOH A O   1 
HETATM 2485 O O   . HOH C 3 .   ? 19.16627  5.84500  -11.99600 1.000 40.24998 ? 556 HOH A O   1 
HETATM 2486 O O   . HOH C 3 .   ? -3.433    34.852   -38.238   1.000 23.35095 ? 557 HOH A O   1 
HETATM 2487 O O   . HOH C 3 .   ? 14.19606  35.19303 -22.14813 1.000 28.13762 ? 558 HOH A O   1 
HETATM 2488 O O   . HOH C 3 .   ? 12.42507  26.62361 3.51442   1.000 39.06292 ? 559 HOH A O   1 
HETATM 2489 O O   . HOH C 3 .   ? 19.60361  5.44488  -3.46588  1.000 43.03366 ? 560 HOH A O   1 
HETATM 2490 O O   . HOH C 3 .   ? 17.55219  19.88551 -20.35249 1.000 22.94146 ? 561 HOH A O   1 
HETATM 2491 O O   . HOH C 3 .   ? 27.35239  27.94484 -18.72956 1.000 34.91286 ? 562 HOH A O   1 
HETATM 2492 O O   . HOH C 3 .   ? 21.54470  33.62268 -16.36809 1.000 35.39234 ? 563 HOH A O   1 
HETATM 2493 O O   . HOH C 3 .   ? 10.87852  27.83044 1.07229   1.000 39.05844 ? 564 HOH A O   1 
HETATM 2494 O O   . HOH C 3 .   ? -9.13953  23.76347 -18.61874 1.000 27.84452 ? 565 HOH A O   1 
HETATM 2495 O O   . HOH C 3 .   ? 28.18824  22.80675 -16.11787 1.000 32.81278 ? 566 HOH A O   1 
HETATM 2496 O O   . HOH C 3 .   ? 14.95706  5.32555  -13.42435 1.000 44.53842 ? 567 HOH A O   1 
HETATM 2497 O O   . HOH C 3 .   ? 10.54029  8.11856  -17.77700 1.000 35.51050 ? 568 HOH A O   1 
HETATM 2498 O O   . HOH C 3 .   ? -15.95790 11.99005 -32.14452 1.000 24.00995 ? 569 HOH A O   1 
HETATM 2499 O O   . HOH C 3 .   ? -7.65750  16.46525 -15.22677 1.000 41.47952 ? 570 HOH A O   1 
HETATM 2500 O O   . HOH C 3 .   ? 16.87038  17.12910 -23.27533 1.000 41.47352 ? 571 HOH A O   1 
HETATM 2501 O O   . HOH C 3 .   ? 7.10314   23.45212 -15.98443 1.000 18.26106 ? 572 HOH A O   1 
HETATM 2502 O O   . HOH C 3 .   ? 0.33383   8.74359  -16.82177 1.000 36.31634 ? 573 HOH A O   1 
HETATM 2503 O O   . HOH C 3 .   ? -3.30388  13.78432 -45.94068 1.000 31.85627 ? 574 HOH A O   1 
HETATM 2504 O O   . HOH C 3 .   ? 20.58636  31.38162 -4.46123  1.000 32.00108 ? 575 HOH A O   1 
HETATM 2505 O O   . HOH C 3 .   ? -7.65151  12.78066 -24.04145 1.000 23.96041 ? 576 HOH A O   1 
HETATM 2506 O O   . HOH C 3 .   ? 20.55759  8.78007  -6.48717  1.000 30.02294 ? 577 HOH A O   1 
HETATM 2507 O O   . HOH C 3 .   ? 18.11906  25.29259 3.16233   1.000 37.65461 ? 578 HOH A O   1 
HETATM 2508 O O   . HOH C 3 .   ? 11.33892  35.99642 -6.47143  1.000 29.72080 ? 579 HOH A O   1 
HETATM 2509 O O   . HOH C 3 .   ? 3.74197   28.41905 -0.39805  1.000 45.00095 ? 580 HOH A O   1 
HETATM 2510 O O   . HOH C 3 .   ? -16.08167 14.86144 -58.56456 1.000 34.79885 ? 581 HOH A O   1 
HETATM 2511 O O   . HOH C 3 .   ? 15.54553  38.54569 -15.39051 1.000 39.02685 ? 582 HOH A O   1 
HETATM 2512 O O   . HOH C 3 .   ? -4.17782  6.42478  -23.61962 1.000 35.59851 ? 583 HOH A O   1 
HETATM 2513 O O   . HOH C 3 .   ? 16.57228  19.37365 0.49999   1.000 32.12162 ? 584 HOH A O   1 
HETATM 2514 O O   . HOH C 3 .   ? 18.06256  6.73278  -18.41259 1.000 37.62848 ? 585 HOH A O   1 
HETATM 2515 O O   . HOH C 3 .   ? -20.26305 24.57094 -34.74015 1.000 45.63470 ? 586 HOH A O   1 
HETATM 2516 O O   . HOH C 3 .   ? -7.43903  29.51349 -40.71859 1.000 40.52597 ? 587 HOH A O   1 
HETATM 2517 O O   . HOH C 3 .   ? -27.99701 8.05321  -28.79851 1.000 39.27317 ? 588 HOH A O   1 
HETATM 2518 O O   . HOH C 3 .   ? -14.66998 5.91018  -28.64297 1.000 34.05684 ? 589 HOH A O   1 
HETATM 2519 O O   . HOH C 3 .   ? -27.86035 11.65025 -49.39551 1.000 37.28754 ? 590 HOH A O   1 
HETATM 2520 O O   . HOH C 3 .   ? 11.34336  36.19283 -11.89872 1.000 41.87861 ? 591 HOH A O   1 
HETATM 2521 O O   . HOH C 3 .   ? -19.74566 3.13793  -32.97888 1.000 33.47448 ? 592 HOH A O   1 
HETATM 2522 O O   . HOH C 3 .   ? -10.19334 5.58375  -29.09947 1.000 28.18144 ? 593 HOH A O   1 
HETATM 2523 O O   . HOH C 3 .   ? 3.83003   21.54476 -0.80348  1.000 33.89542 ? 594 HOH A O   1 
HETATM 2524 O O   . HOH C 3 .   ? 4.83752   9.07563  -35.63630 1.000 53.87452 ? 595 HOH A O   1 
HETATM 2525 O O   . HOH C 3 .   ? -1.069    19.358   -50.940   1.000 39.50348 ? 596 HOH A O   1 
HETATM 2526 O O   . HOH C 3 .   ? 23.05202  11.98581 -4.26820  1.000 44.23103 ? 597 HOH A O   1 
HETATM 2527 O O   . HOH C 3 .   ? 8.03755   16.17518 -19.99375 1.000 28.15305 ? 598 HOH A O   1 
HETATM 2528 O O   . HOH C 3 .   ? 18.59142  37.59977 -22.37919 1.000 28.94816 ? 599 HOH A O   1 
HETATM 2529 O O   . HOH C 3 .   ? 9.24513   35.88658 -9.09225  1.000 27.93133 ? 600 HOH A O   1 
HETATM 2530 O O   . HOH C 3 .   ? -13.30679 13.98075 -14.57456 1.000 36.19975 ? 601 HOH A O   1 
HETATM 2531 O O   . HOH C 3 .   ? 21.54576  14.70226 -16.50080 1.000 32.23887 ? 602 HOH A O   1 
HETATM 2532 O O   . HOH C 3 .   ? -22.07908 20.65022 -26.68808 1.000 44.26845 ? 603 HOH A O   1 
HETATM 2533 O O   . HOH C 3 .   ? 11.78483  17.92344 -23.16276 1.000 29.44986 ? 604 HOH A O   1 
HETATM 2534 O O   . HOH C 3 .   ? -12.14804 5.26550  -27.47473 1.000 32.83725 ? 605 HOH A O   1 
HETATM 2535 O O   . HOH C 3 .   ? -13.97520 3.37748  -36.20051 1.000 42.93090 ? 606 HOH A O   1 
HETATM 2536 O O   . HOH C 3 .   ? 3.02677   24.56658 -6.00990  1.000 34.59790 ? 607 HOH A O   1 
HETATM 2537 O O   . HOH C 3 .   ? 18.15490  32.92843 -21.86203 1.000 33.36178 ? 608 HOH A O   1 
HETATM 2538 O O   . HOH C 3 .   ? -5.14531  9.19670  -39.95032 1.000 33.30630 ? 609 HOH A O   1 
HETATM 2539 O O   . HOH C 3 .   ? 24.08954  22.22865 -22.13518 1.000 24.99502 ? 610 HOH A O   1 
HETATM 2540 O O   . HOH C 3 .   ? 13.20928  24.47559 -34.91443 1.000 46.23643 ? 611 HOH A O   1 
HETATM 2541 O O   . HOH C 3 .   ? 6.00505   27.36896 -23.64219 1.000 22.53136 ? 612 HOH A O   1 
HETATM 2542 O O   . HOH C 3 .   ? -14.96488 3.48357  -43.09962 1.000 35.58855 ? 613 HOH A O   1 
HETATM 2543 O O   . HOH C 3 .   ? 22.54008  14.80654 -10.51706 1.000 28.33426 ? 614 HOH A O   1 
HETATM 2544 O O   . HOH C 3 .   ? -10.86021 1.97306  -37.53978 1.000 44.46264 ? 615 HOH A O   1 
HETATM 2545 O O   . HOH C 3 .   ? -5.52530  26.69395 -48.63035 1.000 33.42804 ? 616 HOH A O   1 
HETATM 2546 O O   . HOH C 3 .   ? 8.39161   13.57880 -14.04657 1.000 28.88554 ? 617 HOH A O   1 
HETATM 2547 O O   . HOH C 3 .   ? -19.67315 2.63099  -41.87172 1.000 42.61507 ? 618 HOH A O   1 
HETATM 2548 O O   . HOH C 3 .   ? -19.06314 23.34659 -21.31171 1.000 26.48101 ? 619 HOH A O   1 
HETATM 2549 O O   . HOH C 3 .   ? -13.87388 15.89743 -58.92673 1.000 36.84486 ? 620 HOH A O   1 
HETATM 2550 O O   . HOH C 3 .   ? 8.83206   27.63422 -23.99882 1.000 24.15242 ? 621 HOH A O   1 
HETATM 2551 O O   . HOH C 3 .   ? 3.31564   16.95389 -31.50340 1.000 27.30313 ? 622 HOH A O   1 
HETATM 2552 O O   . HOH C 3 .   ? -15.53437 0.16857  -37.78819 1.000 54.15550 ? 623 HOH A O   1 
HETATM 2553 O O   . HOH C 3 .   ? 0.46889   20.60912 -10.65255 1.000 49.32731 ? 624 HOH A O   1 
HETATM 2554 O O   . HOH C 3 .   ? 0.09045   5.54617  -26.01070 1.000 47.70645 ? 625 HOH A O   1 
HETATM 2555 O O   . HOH C 3 .   ? -19.99347 25.77672 -24.90405 1.000 27.48017 ? 626 HOH A O   1 
HETATM 2556 O O   . HOH C 3 .   ? 25.901    16.735   -6.291    1.000 54.54268 ? 627 HOH A O   1 
HETATM 2557 O O   . HOH C 3 .   ? 18.83417  6.70638  -5.36255  1.000 35.23358 ? 628 HOH A O   1 
HETATM 2558 O O   . HOH C 3 .   ? -9.74870  4.86367  -42.88645 1.000 49.57755 ? 629 HOH A O   1 
HETATM 2559 O O   . HOH C 3 .   ? 3.05189   10.59556 -39.96216 1.000 40.75276 ? 630 HOH A O   1 
HETATM 2560 O O   . HOH C 3 .   ? 7.25710   13.98960 -42.29342 1.000 46.14353 ? 631 HOH A O   1 
HETATM 2561 O O   . HOH C 3 .   ? -22.44303 11.50788 -52.94669 1.000 36.97228 ? 632 HOH A O   1 
HETATM 2562 O O   . HOH C 3 .   ? 13.10011  27.05651 0.05142   1.000 35.58793 ? 633 HOH A O   1 
HETATM 2563 O O   . HOH C 3 .   ? 8.38881   19.77422 -28.58041 1.000 50.66595 ? 634 HOH A O   1 
HETATM 2564 O O   . HOH C 3 .   ? 0.39855   8.20454  -24.54964 1.000 40.13443 ? 635 HOH A O   1 
HETATM 2565 O O   . HOH C 3 .   ? -26.88167 -0.19935 -41.61586 1.000 43.94683 ? 636 HOH A O   1 
HETATM 2566 O O   . HOH C 3 .   ? -6.31570  32.05737 -40.26961 1.000 43.55357 ? 637 HOH A O   1 
HETATM 2567 O O   . HOH C 3 .   ? 9.18445   36.97357 -17.13598 1.000 33.96515 ? 638 HOH A O   1 
HETATM 2568 O O   . HOH C 3 .   ? 4.16673   8.65666  -32.54011 1.000 33.86620 ? 639 HOH A O   1 
HETATM 2569 O O   . HOH C 3 .   ? 20.42271  10.00946 -11.06354 1.000 38.39806 ? 640 HOH A O   1 
HETATM 2570 O O   . HOH C 3 .   ? 3.216     33.273   -18.935   1.000 43.27998 ? 641 HOH A O   1 
HETATM 2571 O O   . HOH C 3 .   ? 20.46719  26.00192 2.19252   1.000 33.50636 ? 642 HOH A O   1 
HETATM 2572 O O   . HOH C 3 .   ? -6.63520  4.49090  -27.63240 1.000 44.91637 ? 643 HOH A O   1 
HETATM 2573 O O   . HOH C 3 .   ? 23.48557  16.57270 -13.24086 1.000 40.22843 ? 644 HOH A O   1 
HETATM 2574 O O   . HOH C 3 .   ? -3.52362  7.82889  -15.89173 1.000 49.55866 ? 645 HOH A O   1 
HETATM 2575 O O   . HOH C 3 .   ? 6.57856   18.30756 -25.77012 1.000 31.82496 ? 646 HOH A O   1 
HETATM 2576 O O   . HOH C 3 .   ? -26.62202 15.94672 -49.85564 1.000 27.83289 ? 647 HOH A O   1 
HETATM 2577 O O   . HOH C 3 .   ? -19.32312 28.57941 -29.21450 1.000 44.28720 ? 648 HOH A O   1 
HETATM 2578 O O   . HOH C 3 .   ? 15.73679  35.29241 -6.35588  1.000 32.21150 ? 649 HOH A O   1 
HETATM 2579 O O   . HOH C 3 .   ? 14.46627  5.54191  -16.79696 1.000 38.21345 ? 650 HOH A O   1 
HETATM 2580 O O   . HOH C 3 .   ? -12.21359 30.99626 -27.63646 1.000 27.11151 ? 651 HOH A O   1 
HETATM 2581 O O   . HOH C 3 .   ? 17.89080  17.09558 0.53582   1.000 40.85745 ? 652 HOH A O   1 
HETATM 2582 O O   . HOH C 3 .   ? -15.94261 9.88278  -56.20740 1.000 43.56630 ? 653 HOH A O   1 
HETATM 2583 O O   . HOH C 3 .   ? -1.40986  6.51883  -24.50723 1.000 48.43990 ? 654 HOH A O   1 
HETATM 2584 O O   . HOH C 3 .   ? 16.84314  28.04346 -34.51227 1.000 37.01039 ? 655 HOH A O   1 
HETATM 2585 O O   . HOH C 3 .   ? 1.18056   24.27609 -13.92131 1.000 34.85448 ? 656 HOH A O   1 
HETATM 2586 O O   . HOH C 3 .   ? -21.76981 5.13696  -48.60997 1.000 49.90985 ? 657 HOH A O   1 
HETATM 2587 O O   . HOH C 3 .   ? 4.906     15.888   -45.117   1.000 31.95191 ? 658 HOH A O   1 
HETATM 2588 O O   . HOH C 3 .   ? 22.48020  10.76947 -13.25304 1.000 36.67867 ? 659 HOH A O   1 
HETATM 2589 O O   . HOH C 3 .   ? -16.09833 6.38995  -49.99325 1.000 38.49671 ? 660 HOH A O   1 
HETATM 2590 O O   . HOH C 3 .   ? -20.35139 8.03397  -51.51644 1.000 41.77938 ? 661 HOH A O   1 
HETATM 2591 O O   . HOH C 3 .   ? 16.40203  36.57336 -2.24029  1.000 47.55169 ? 662 HOH A O   1 
HETATM 2592 O O   . HOH C 3 .   ? 7.81802   27.16409 -27.27597 1.000 31.09178 ? 663 HOH A O   1 
HETATM 2593 O O   . HOH C 3 .   ? 1.482     22.210   -51.794   1.000 42.52765 ? 664 HOH A O   1 
HETATM 2594 O O   . HOH C 3 .   ? 13.18169  22.81756 -33.27257 1.000 46.69499 ? 665 HOH A O   1 
HETATM 2595 O O   . HOH C 3 .   ? 3.79325   13.61856 -44.68267 1.000 48.31888 ? 666 HOH A O   1 
HETATM 2596 O O   . HOH C 3 .   ? -5.17431  2.12828  -34.74631 1.000 44.36289 ? 667 HOH A O   1 
HETATM 2597 O O   . HOH C 3 .   ? -16.69826 7.00915  -52.75925 1.000 45.30322 ? 668 HOH A O   1 
HETATM 2598 O O   . HOH C 3 .   ? 9.01235   36.91917 -4.28413  1.000 36.74922 ? 669 HOH A O   1 
HETATM 2599 O O   . HOH C 3 .   ? 22.37675  13.83334 -20.21325 1.000 34.18951 ? 670 HOH A O   1 
HETATM 2600 O O   . HOH C 3 .   ? -5.77288  2.35916  -37.08329 1.000 50.59745 ? 671 HOH A O   1 
HETATM 2601 O O   . HOH C 3 .   ? -22.37413 4.20248  -28.10833 1.000 53.07134 ? 672 HOH A O   1 
HETATM 2602 O O   . HOH C 3 .   ? 0.06224   28.63808 -44.26296 1.000 36.70392 ? 673 HOH A O   1 
HETATM 2603 O O   . HOH C 3 .   ? 16.56512  20.26193 -22.95946 1.000 31.03574 ? 674 HOH A O   1 
HETATM 2604 O O   . HOH C 3 .   ? -10.44198 8.27552  -47.33147 1.000 48.21566 ? 675 HOH A O   1 
HETATM 2605 O O   . HOH C 3 .   ? -10.19028 15.96631 -14.06103 1.000 44.84318 ? 676 HOH A O   1 
HETATM 2606 O O   . HOH C 3 .   ? 15.01170  19.58691 2.52245   1.000 38.78623 ? 677 HOH A O   1 
HETATM 2607 O O   . HOH C 3 .   ? -4.63965  4.05040  -25.44862 1.000 45.81199 ? 678 HOH A O   1 
HETATM 2608 O O   . HOH C 3 .   ? -16.97434 4.61310  -44.93581 1.000 46.66010 ? 679 HOH A O   1 
HETATM 2609 O O   . HOH C 3 .   ? 18.35334  5.36878  -7.63333  1.000 49.53487 ? 680 HOH A O   1 
HETATM 2610 O O   . HOH C 3 .   ? 16.20209  33.60829 -20.60355 1.000 33.89640 ? 681 HOH A O   1 
HETATM 2611 O O   . HOH C 3 .   ? 22.268    14.393   1.648     1.000 42.07403 ? 682 HOH A O   1 
HETATM 2612 O O   . HOH C 3 .   ? -7.28681  3.45572  -21.84631 1.000 49.68712 ? 683 HOH A O   1 
HETATM 2613 O O   . HOH C 3 .   ? 7.87253   13.39071 -19.29126 1.000 43.93103 ? 684 HOH A O   1 
HETATM 2614 O O   . HOH C 3 .   ? 11.50642  5.14848  -17.41134 1.000 44.45513 ? 685 HOH A O   1 
HETATM 2615 O O   . HOH C 3 .   ? 23.19459  15.97448 -15.69056 1.000 39.41360 ? 686 HOH A O   1 
HETATM 2616 O O   . HOH C 3 .   ? -17.03820 4.20722  -28.63676 1.000 46.14949 ? 687 HOH A O   1 
HETATM 2617 O O   . HOH C 3 .   ? 8.11134   7.95285  -16.31426 1.000 42.17095 ? 688 HOH A O   1 
HETATM 2618 O O   . HOH C 3 .   ? 5.253     29.362   -42.361   1.000 47.59926 ? 689 HOH A O   1 
HETATM 2619 O O   . HOH C 3 .   ? -3.33898  8.43373  -41.02512 1.000 40.45716 ? 690 HOH A O   1 
HETATM 2620 O O   . HOH C 3 .   ? 26.09879  27.99512 -21.10916 1.000 39.73319 ? 691 HOH A O   1 
HETATM 2621 O O   . HOH C 3 .   ? 22.02787  12.55845 -0.04589  1.000 49.36810 ? 692 HOH A O   1 
HETATM 2622 O O   . HOH C 3 .   ? -5.32764  4.93481  -21.13286 1.000 45.63248 ? 693 HOH A O   1 
HETATM 2623 O O   . HOH C 3 .   ? -21.378   13.873   -18.614   1.000 46.23445 ? 694 HOH A O   1 
HETATM 2624 O O   . HOH C 3 .   ? -19.42549 3.77001  -44.48524 1.000 34.50438 ? 695 HOH A O   1 
HETATM 2625 O O   . HOH C 3 .   ? -0.85583  30.18496 -19.17830 1.000 41.86796 ? 696 HOH A O   1 
HETATM 2626 O O   . HOH C 3 .   ? 6.08579   16.12128 -31.39555 1.000 38.90559 ? 697 HOH A O   1 
HETATM 2627 O O   . HOH C 3 .   ? 18.57977  27.44264 1.69548   1.000 47.86254 ? 698 HOH A O   1 
HETATM 2628 O O   . HOH C 3 .   ? -6.223    35.439   -38.522   1.000 40.93755 ? 699 HOH A O   1 
HETATM 2629 O O   . HOH C 3 .   ? -28.74109 11.73498 -44.27816 1.000 53.08169 ? 700 HOH A O   1 
HETATM 2630 O O   . HOH C 3 .   ? -19.291   16.937   -12.531   1.000 41.99972 ? 701 HOH A O   1 
HETATM 2631 O O   . HOH C 3 .   ? -6.05779  7.11014  -16.67672 1.000 41.10630 ? 702 HOH A O   1 
HETATM 2632 O O   . HOH C 3 .   ? 20.90598  8.39039  -9.18686  1.000 35.71775 ? 703 HOH A O   1 
HETATM 2633 O O   . HOH C 3 .   ? 22.93317  9.81923  -5.48096  1.000 38.55484 ? 704 HOH A O   1 
HETATM 2634 O O   . HOH C 3 .   ? -12.33407 2.71420  -26.86911 1.000 42.92678 ? 705 HOH A O   1 
HETATM 2635 O O   . HOH C 3 .   ? -5.38698  5.09905  -18.74187 1.000 47.21013 ? 706 HOH A O   1 
HETATM 2636 O O   . HOH C 3 .   ? -21.783   22.835   -24.632   1.000 38.27995 ? 707 HOH A O   1 
HETATM 2637 O O   . HOH C 3 .   ? -8.11995  12.63044 -56.99034 1.000 39.84023 ? 708 HOH A O   1 
HETATM 2638 O O   . HOH C 3 .   ? 2.85144   20.72557 -3.57368  1.000 41.64292 ? 709 HOH A O   1 
HETATM 2639 O O   . HOH C 3 .   ? 9.63292   15.96920 -22.00548 1.000 37.24769 ? 710 HOH A O   1 
HETATM 2640 O O   . HOH C 3 .   ? 21.13502  23.31694 -24.75043 1.000 43.78680 ? 711 HOH A O   1 
HETATM 2641 O O   . HOH C 3 .   ? 22.06766  12.14132 -11.14211 1.000 37.06477 ? 712 HOH A O   1 
HETATM 2642 O O   . HOH C 3 .   ? 24.87283  14.49995 -8.88151  1.000 38.69965 ? 713 HOH A O   1 
# 
