data_9BO2
# 
_entry.id   9BO2 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BO2         pdb_00009bo2 10.2210/pdb9bo2/pdb 
WWPDB D_1000282930 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-12 ? 
2 'Structure model' 1 1 2025-03-12 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
_pdbx_audit_revision_category.ordinal             1 
_pdbx_audit_revision_category.revision_ordinal    2 
_pdbx_audit_revision_category.data_content_type   'Structure model' 
_pdbx_audit_revision_category.category            citation 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
5 2 'Structure model' '_citation.title'                   
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BO2 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-03 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              karen.anderson@yale.edu 
_pdbx_contact_author.name_first         Karen 
_pdbx_contact_author.name_last          Anderson 
_pdbx_contact_author.name_mi            S 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-3433-0780 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Papini, C.'      1 0000-0002-6098-4959 
'Kenneson, J.'    2 ?                   
'Zhang, C.H.'     3 ?                   
'Jorgensen, W.L.' 4 ?                   
'Anderson, K.S.'  5 0000-0003-3433-0780 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Acs Bio Med Chem Au' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2694-2437 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            5 
_citation.language                  ? 
_citation.page_first                215 
_citation.page_last                 226 
_citation.title                     
'Exploring Possible Drug-Resistant Variants of SARS-CoV-2 Main Protease (M pro ) with Noncovalent Preclinical Candidate, Mpro61.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acsbiomedchemau.4c00109 
_citation.pdbx_database_id_PubMed   39990941 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Kenneson, J.R.'  1 ? 
primary 'Papini, C.'      2 ? 
primary 'Tang, S.'        3 ? 
primary 'Huynh, K.'       4 ? 
primary 'Zhang, C.H.'     5 ? 
primary 'Jorgensen, W.L.' 6 ? 
primary 'Anderson, K.S.'  7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '3C-like proteinase nsp5' 33887.613 1   3.4.22.69 ? ? ? 
2 non-polymer syn 
;(5P)-5-[(1P,3M,3'P)-3-{3-chloro-5-[(2-chlorophenyl)methoxy]-4-fluorophenyl}-2-oxo-2H-[1,3'-bipyridin]-5-yl]-1-methylpyrimidine-2,4(1H,3H)-dione
;
565.379   1   ?         ? ? ? 
3 water       nat water 18.015    165 ?         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMFNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHVGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMFNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHVGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 
;(5P)-5-[(1P,3M,3'P)-3-{3-chloro-5-[(2-chlorophenyl)methoxy]-4-fluorophenyl}-2-oxo-2H-[1,3'-bipyridin]-5-yl]-1-methylpyrimidine-2,4(1H,3H)-dione
;
XEK 
3 water HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   GLY n 
1 3   PHE n 
1 4   ARG n 
1 5   LYS n 
1 6   MET n 
1 7   ALA n 
1 8   PHE n 
1 9   PRO n 
1 10  SER n 
1 11  GLY n 
1 12  LYS n 
1 13  VAL n 
1 14  GLU n 
1 15  GLY n 
1 16  CYS n 
1 17  MET n 
1 18  VAL n 
1 19  GLN n 
1 20  VAL n 
1 21  THR n 
1 22  CYS n 
1 23  GLY n 
1 24  THR n 
1 25  THR n 
1 26  THR n 
1 27  LEU n 
1 28  ASN n 
1 29  GLY n 
1 30  LEU n 
1 31  TRP n 
1 32  LEU n 
1 33  ASP n 
1 34  ASP n 
1 35  VAL n 
1 36  VAL n 
1 37  TYR n 
1 38  CYS n 
1 39  PRO n 
1 40  ARG n 
1 41  HIS n 
1 42  VAL n 
1 43  ILE n 
1 44  CYS n 
1 45  THR n 
1 46  SER n 
1 47  GLU n 
1 48  ASP n 
1 49  MET n 
1 50  PHE n 
1 51  ASN n 
1 52  PRO n 
1 53  ASN n 
1 54  TYR n 
1 55  GLU n 
1 56  ASP n 
1 57  LEU n 
1 58  LEU n 
1 59  ILE n 
1 60  ARG n 
1 61  LYS n 
1 62  SER n 
1 63  ASN n 
1 64  HIS n 
1 65  ASN n 
1 66  PHE n 
1 67  LEU n 
1 68  VAL n 
1 69  GLN n 
1 70  ALA n 
1 71  GLY n 
1 72  ASN n 
1 73  VAL n 
1 74  GLN n 
1 75  LEU n 
1 76  ARG n 
1 77  VAL n 
1 78  ILE n 
1 79  GLY n 
1 80  HIS n 
1 81  SER n 
1 82  MET n 
1 83  GLN n 
1 84  ASN n 
1 85  CYS n 
1 86  VAL n 
1 87  LEU n 
1 88  LYS n 
1 89  LEU n 
1 90  LYS n 
1 91  VAL n 
1 92  ASP n 
1 93  THR n 
1 94  ALA n 
1 95  ASN n 
1 96  PRO n 
1 97  LYS n 
1 98  THR n 
1 99  PRO n 
1 100 LYS n 
1 101 TYR n 
1 102 LYS n 
1 103 PHE n 
1 104 VAL n 
1 105 ARG n 
1 106 ILE n 
1 107 GLN n 
1 108 PRO n 
1 109 GLY n 
1 110 GLN n 
1 111 THR n 
1 112 PHE n 
1 113 SER n 
1 114 VAL n 
1 115 LEU n 
1 116 ALA n 
1 117 CYS n 
1 118 TYR n 
1 119 ASN n 
1 120 GLY n 
1 121 SER n 
1 122 PRO n 
1 123 SER n 
1 124 GLY n 
1 125 VAL n 
1 126 TYR n 
1 127 GLN n 
1 128 CYS n 
1 129 ALA n 
1 130 MET n 
1 131 ARG n 
1 132 PRO n 
1 133 ASN n 
1 134 PHE n 
1 135 THR n 
1 136 ILE n 
1 137 LYS n 
1 138 GLY n 
1 139 SER n 
1 140 PHE n 
1 141 LEU n 
1 142 ASN n 
1 143 GLY n 
1 144 SER n 
1 145 CYS n 
1 146 GLY n 
1 147 SER n 
1 148 VAL n 
1 149 GLY n 
1 150 PHE n 
1 151 ASN n 
1 152 ILE n 
1 153 ASP n 
1 154 TYR n 
1 155 ASP n 
1 156 CYS n 
1 157 VAL n 
1 158 SER n 
1 159 PHE n 
1 160 CYS n 
1 161 TYR n 
1 162 MET n 
1 163 HIS n 
1 164 HIS n 
1 165 MET n 
1 166 GLU n 
1 167 LEU n 
1 168 PRO n 
1 169 THR n 
1 170 GLY n 
1 171 VAL n 
1 172 HIS n 
1 173 VAL n 
1 174 GLY n 
1 175 THR n 
1 176 ASP n 
1 177 LEU n 
1 178 GLU n 
1 179 GLY n 
1 180 ASN n 
1 181 PHE n 
1 182 TYR n 
1 183 GLY n 
1 184 PRO n 
1 185 PHE n 
1 186 VAL n 
1 187 ASP n 
1 188 ARG n 
1 189 GLN n 
1 190 THR n 
1 191 ALA n 
1 192 GLN n 
1 193 ALA n 
1 194 ALA n 
1 195 GLY n 
1 196 THR n 
1 197 ASP n 
1 198 THR n 
1 199 THR n 
1 200 ILE n 
1 201 THR n 
1 202 VAL n 
1 203 ASN n 
1 204 VAL n 
1 205 LEU n 
1 206 ALA n 
1 207 TRP n 
1 208 LEU n 
1 209 TYR n 
1 210 ALA n 
1 211 ALA n 
1 212 VAL n 
1 213 ILE n 
1 214 ASN n 
1 215 GLY n 
1 216 ASP n 
1 217 ARG n 
1 218 TRP n 
1 219 PHE n 
1 220 LEU n 
1 221 ASN n 
1 222 ARG n 
1 223 PHE n 
1 224 THR n 
1 225 THR n 
1 226 THR n 
1 227 LEU n 
1 228 ASN n 
1 229 ASP n 
1 230 PHE n 
1 231 ASN n 
1 232 LEU n 
1 233 VAL n 
1 234 ALA n 
1 235 MET n 
1 236 LYS n 
1 237 TYR n 
1 238 ASN n 
1 239 TYR n 
1 240 GLU n 
1 241 PRO n 
1 242 LEU n 
1 243 THR n 
1 244 GLN n 
1 245 ASP n 
1 246 HIS n 
1 247 VAL n 
1 248 ASP n 
1 249 ILE n 
1 250 LEU n 
1 251 GLY n 
1 252 PRO n 
1 253 LEU n 
1 254 SER n 
1 255 ALA n 
1 256 GLN n 
1 257 THR n 
1 258 GLY n 
1 259 ILE n 
1 260 ALA n 
1 261 VAL n 
1 262 LEU n 
1 263 ASP n 
1 264 MET n 
1 265 CYS n 
1 266 ALA n 
1 267 SER n 
1 268 LEU n 
1 269 LYS n 
1 270 GLU n 
1 271 LEU n 
1 272 LEU n 
1 273 GLN n 
1 274 ASN n 
1 275 GLY n 
1 276 MET n 
1 277 ASN n 
1 278 GLY n 
1 279 ARG n 
1 280 THR n 
1 281 ILE n 
1 282 LEU n 
1 283 GLY n 
1 284 SER n 
1 285 ALA n 
1 286 LEU n 
1 287 LEU n 
1 288 GLU n 
1 289 ASP n 
1 290 GLU n 
1 291 PHE n 
1 292 THR n 
1 293 PRO n 
1 294 PHE n 
1 295 ASP n 
1 296 VAL n 
1 297 VAL n 
1 298 ARG n 
1 299 GLN n 
1 300 CYS n 
1 301 SER n 
1 302 GLY n 
1 303 VAL n 
1 304 THR n 
1 305 PHE n 
1 306 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   306 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'rep, 1a-1b' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2'          89.093  
ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1'      175.209 
ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'         132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'          133.103 
CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'        121.158 
GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'        146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'          147.129 
GLY 'peptide linking'   y GLYCINE ? 'C2 H5 N O2'          75.067  
HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1'      156.162 
HOH non-polymer         . WATER ? 'H2 O'                18.015  
ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'         131.173 
LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'         131.173 
LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1'      147.195 
MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'       149.211 
PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'         165.189 
PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2'          115.130 
SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3'          105.093 
THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3'          119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'       204.225 
TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'         181.189 
VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2'         117.146 
XEK non-polymer         . 
;(5P)-5-[(1P,3M,3'P)-3-{3-chloro-5-[(2-chlorophenyl)methoxy]-4-fluorophenyl}-2-oxo-2H-[1,3'-bipyridin]-5-yl]-1-methylpyrimidine-2,4(1H,3H)-dione
;
? 'C28 H19 Cl2 F N4 O4' 565.379 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   1   1   SER SER A . n 
A 1 2   GLY 2   2   2   GLY GLY A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   ARG 4   4   4   ARG ARG A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   MET 6   6   6   MET MET A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   PRO 9   9   9   PRO PRO A . n 
A 1 10  SER 10  10  10  SER SER A . n 
A 1 11  GLY 11  11  11  GLY GLY A . n 
A 1 12  LYS 12  12  12  LYS LYS A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  GLY 15  15  15  GLY GLY A . n 
A 1 16  CYS 16  16  16  CYS CYS A . n 
A 1 17  MET 17  17  17  MET MET A . n 
A 1 18  VAL 18  18  18  VAL VAL A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  THR 21  21  21  THR THR A . n 
A 1 22  CYS 22  22  22  CYS CYS A . n 
A 1 23  GLY 23  23  23  GLY GLY A . n 
A 1 24  THR 24  24  24  THR THR A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  THR 26  26  26  THR THR A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  ASN 28  28  28  ASN ASN A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  TRP 31  31  31  TRP TRP A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  ASP 33  33  33  ASP ASP A . n 
A 1 34  ASP 34  34  34  ASP ASP A . n 
A 1 35  VAL 35  35  35  VAL VAL A . n 
A 1 36  VAL 36  36  36  VAL VAL A . n 
A 1 37  TYR 37  37  37  TYR TYR A . n 
A 1 38  CYS 38  38  38  CYS CYS A . n 
A 1 39  PRO 39  39  39  PRO PRO A . n 
A 1 40  ARG 40  40  40  ARG ARG A . n 
A 1 41  HIS 41  41  41  HIS HIS A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  ILE 43  43  43  ILE ILE A . n 
A 1 44  CYS 44  44  44  CYS CYS A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  SER 46  46  46  SER SER A . n 
A 1 47  GLU 47  47  47  GLU GLU A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  MET 49  49  49  MET MET A . n 
A 1 50  PHE 50  50  50  PHE PHE A . n 
A 1 51  ASN 51  51  51  ASN ASN A . n 
A 1 52  PRO 52  52  52  PRO PRO A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  TYR 54  54  54  TYR TYR A . n 
A 1 55  GLU 55  55  55  GLU GLU A . n 
A 1 56  ASP 56  56  56  ASP ASP A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  ILE 59  59  59  ILE ILE A . n 
A 1 60  ARG 60  60  60  ARG ARG A . n 
A 1 61  LYS 61  61  61  LYS LYS A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  ASN 63  63  63  ASN ASN A . n 
A 1 64  HIS 64  64  64  HIS HIS A . n 
A 1 65  ASN 65  65  65  ASN ASN A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  GLN 69  69  69  GLN GLN A . n 
A 1 70  ALA 70  70  70  ALA ALA A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  ASN 72  72  72  ASN ASN A . n 
A 1 73  VAL 73  73  73  VAL VAL A . n 
A 1 74  GLN 74  74  74  GLN GLN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  ARG 76  76  76  ARG ARG A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  GLY 79  79  79  GLY GLY A . n 
A 1 80  HIS 80  80  80  HIS HIS A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  MET 82  82  82  MET MET A . n 
A 1 83  GLN 83  83  83  GLN GLN A . n 
A 1 84  ASN 84  84  84  ASN ASN A . n 
A 1 85  CYS 85  85  85  CYS CYS A . n 
A 1 86  VAL 86  86  86  VAL VAL A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  LYS 88  88  88  LYS LYS A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  LYS 90  90  90  LYS LYS A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  ASP 92  92  92  ASP ASP A . n 
A 1 93  THR 93  93  93  THR THR A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  PRO 96  96  96  PRO PRO A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  PRO 99  99  99  PRO PRO A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 TYR 101 101 101 TYR TYR A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 PHE 103 103 103 PHE PHE A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 ARG 105 105 105 ARG ARG A . n 
A 1 106 ILE 106 106 106 ILE ILE A . n 
A 1 107 GLN 107 107 107 GLN GLN A . n 
A 1 108 PRO 108 108 108 PRO PRO A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 GLN 110 110 110 GLN GLN A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 PHE 112 112 112 PHE PHE A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 CYS 117 117 117 CYS CYS A . n 
A 1 118 TYR 118 118 118 TYR TYR A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 SER 123 123 123 SER SER A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 MET 130 130 130 MET MET A . n 
A 1 131 ARG 131 131 131 ARG ARG A . n 
A 1 132 PRO 132 132 132 PRO PRO A . n 
A 1 133 ASN 133 133 133 ASN ASN A . n 
A 1 134 PHE 134 134 134 PHE PHE A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 LYS 137 137 137 LYS LYS A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 PHE 140 140 140 PHE PHE A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 ASN 142 142 142 ASN ASN A . n 
A 1 143 GLY 143 143 143 GLY GLY A . n 
A 1 144 SER 144 144 144 SER SER A . n 
A 1 145 CYS 145 145 145 CYS CYS A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 GLY 149 149 149 GLY GLY A . n 
A 1 150 PHE 150 150 150 PHE PHE A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 ILE 152 152 152 ILE ILE A . n 
A 1 153 ASP 153 153 153 ASP ASP A . n 
A 1 154 TYR 154 154 154 TYR TYR A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 CYS 156 156 156 CYS CYS A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 SER 158 158 158 SER SER A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 CYS 160 160 160 CYS CYS A . n 
A 1 161 TYR 161 161 161 TYR TYR A . n 
A 1 162 MET 162 162 162 MET MET A . n 
A 1 163 HIS 163 163 163 HIS HIS A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 MET 165 165 165 MET MET A . n 
A 1 166 GLU 166 166 166 GLU GLU A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 PRO 168 168 168 PRO PRO A . n 
A 1 169 THR 169 169 169 THR THR A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 VAL 171 171 171 VAL VAL A . n 
A 1 172 HIS 172 172 172 HIS HIS A . n 
A 1 173 VAL 173 173 173 VAL VAL A . n 
A 1 174 GLY 174 174 174 GLY GLY A . n 
A 1 175 THR 175 175 175 THR THR A . n 
A 1 176 ASP 176 176 176 ASP ASP A . n 
A 1 177 LEU 177 177 177 LEU LEU A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 TYR 182 182 182 TYR TYR A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 VAL 186 186 186 VAL VAL A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 GLN 189 189 189 GLN GLN A . n 
A 1 190 THR 190 190 190 THR THR A . n 
A 1 191 ALA 191 191 191 ALA ALA A . n 
A 1 192 GLN 192 192 192 GLN GLN A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 THR 196 196 196 THR THR A . n 
A 1 197 ASP 197 197 197 ASP ASP A . n 
A 1 198 THR 198 198 198 THR THR A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 ILE 200 200 200 ILE ILE A . n 
A 1 201 THR 201 201 201 THR THR A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 ALA 206 206 206 ALA ALA A . n 
A 1 207 TRP 207 207 207 TRP TRP A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ALA 210 210 210 ALA ALA A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ASN 214 214 214 ASN ASN A . n 
A 1 215 GLY 215 215 215 GLY GLY A . n 
A 1 216 ASP 216 216 216 ASP ASP A . n 
A 1 217 ARG 217 217 217 ARG ARG A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 ASN 221 221 221 ASN ASN A . n 
A 1 222 ARG 222 222 222 ARG ARG A . n 
A 1 223 PHE 223 223 223 PHE PHE A . n 
A 1 224 THR 224 224 224 THR THR A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 THR 226 226 226 THR THR A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 ASN 228 228 228 ASN ASN A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 PHE 230 230 230 PHE PHE A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 VAL 233 233 233 VAL VAL A . n 
A 1 234 ALA 234 234 234 ALA ALA A . n 
A 1 235 MET 235 235 235 MET MET A . n 
A 1 236 LYS 236 236 236 LYS LYS A . n 
A 1 237 TYR 237 237 237 TYR TYR A . n 
A 1 238 ASN 238 238 238 ASN ASN A . n 
A 1 239 TYR 239 239 239 TYR TYR A . n 
A 1 240 GLU 240 240 240 GLU GLU A . n 
A 1 241 PRO 241 241 241 PRO PRO A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 THR 243 243 243 THR THR A . n 
A 1 244 GLN 244 244 244 GLN GLN A . n 
A 1 245 ASP 245 245 245 ASP ASP A . n 
A 1 246 HIS 246 246 246 HIS HIS A . n 
A 1 247 VAL 247 247 247 VAL VAL A . n 
A 1 248 ASP 248 248 248 ASP ASP A . n 
A 1 249 ILE 249 249 249 ILE ILE A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 PRO 252 252 252 PRO PRO A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 SER 254 254 254 SER SER A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 THR 257 257 257 THR THR A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 ILE 259 259 259 ILE ILE A . n 
A 1 260 ALA 260 260 260 ALA ALA A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 LEU 262 262 262 LEU LEU A . n 
A 1 263 ASP 263 263 263 ASP ASP A . n 
A 1 264 MET 264 264 264 MET MET A . n 
A 1 265 CYS 265 265 265 CYS CYS A . n 
A 1 266 ALA 266 266 266 ALA ALA A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 LYS 269 269 269 LYS LYS A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 LEU 271 271 271 LEU LEU A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 ASN 274 274 274 ASN ASN A . n 
A 1 275 GLY 275 275 275 GLY GLY A . n 
A 1 276 MET 276 276 276 MET MET A . n 
A 1 277 ASN 277 277 277 ASN ASN A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 ARG 279 279 279 ARG ARG A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 ILE 281 281 281 ILE ILE A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 GLY 283 283 283 GLY GLY A . n 
A 1 284 SER 284 284 284 SER SER A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 LEU 286 286 286 LEU LEU A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 ASP 289 289 289 ASP ASP A . n 
A 1 290 GLU 290 290 290 GLU GLU A . n 
A 1 291 PHE 291 291 291 PHE PHE A . n 
A 1 292 THR 292 292 292 THR THR A . n 
A 1 293 PRO 293 293 293 PRO PRO A . n 
A 1 294 PHE 294 294 294 PHE PHE A . n 
A 1 295 ASP 295 295 295 ASP ASP A . n 
A 1 296 VAL 296 296 296 VAL VAL A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 GLN 299 299 299 GLN GLN A . n 
A 1 300 CYS 300 300 300 CYS CYS A . n 
A 1 301 SER 301 301 301 SER SER A . n 
A 1 302 GLY 302 302 ?   ?   ?   A . n 
A 1 303 VAL 303 303 ?   ?   ?   A . n 
A 1 304 THR 304 304 ?   ?   ?   A . n 
A 1 305 PHE 305 305 ?   ?   ?   A . n 
A 1 306 GLN 306 306 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        XEK 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   XEK 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 XEK 1   401 999 XEK M61 A . 
C 3 HOH 1   501 78  HOH HOH A . 
C 3 HOH 2   502 43  HOH HOH A . 
C 3 HOH 3   503 173 HOH HOH A . 
C 3 HOH 4   504 111 HOH HOH A . 
C 3 HOH 5   505 48  HOH HOH A . 
C 3 HOH 6   506 76  HOH HOH A . 
C 3 HOH 7   507 50  HOH HOH A . 
C 3 HOH 8   508 103 HOH HOH A . 
C 3 HOH 9   509 14  HOH HOH A . 
C 3 HOH 10  510 163 HOH HOH A . 
C 3 HOH 11  511 68  HOH HOH A . 
C 3 HOH 12  512 153 HOH HOH A . 
C 3 HOH 13  513 125 HOH HOH A . 
C 3 HOH 14  514 92  HOH HOH A . 
C 3 HOH 15  515 49  HOH HOH A . 
C 3 HOH 16  516 79  HOH HOH A . 
C 3 HOH 17  517 95  HOH HOH A . 
C 3 HOH 18  518 122 HOH HOH A . 
C 3 HOH 19  519 15  HOH HOH A . 
C 3 HOH 20  520 84  HOH HOH A . 
C 3 HOH 21  521 101 HOH HOH A . 
C 3 HOH 22  522 105 HOH HOH A . 
C 3 HOH 23  523 5   HOH HOH A . 
C 3 HOH 24  524 10  HOH HOH A . 
C 3 HOH 25  525 77  HOH HOH A . 
C 3 HOH 26  526 118 HOH HOH A . 
C 3 HOH 27  527 52  HOH HOH A . 
C 3 HOH 28  528 126 HOH HOH A . 
C 3 HOH 29  529 69  HOH HOH A . 
C 3 HOH 30  530 113 HOH HOH A . 
C 3 HOH 31  531 106 HOH HOH A . 
C 3 HOH 32  532 1   HOH HOH A . 
C 3 HOH 33  533 39  HOH HOH A . 
C 3 HOH 34  534 93  HOH HOH A . 
C 3 HOH 35  535 114 HOH HOH A . 
C 3 HOH 36  536 47  HOH HOH A . 
C 3 HOH 37  537 146 HOH HOH A . 
C 3 HOH 38  538 67  HOH HOH A . 
C 3 HOH 39  539 24  HOH HOH A . 
C 3 HOH 40  540 46  HOH HOH A . 
C 3 HOH 41  541 3   HOH HOH A . 
C 3 HOH 42  542 94  HOH HOH A . 
C 3 HOH 43  543 42  HOH HOH A . 
C 3 HOH 44  544 104 HOH HOH A . 
C 3 HOH 45  545 41  HOH HOH A . 
C 3 HOH 46  546 13  HOH HOH A . 
C 3 HOH 47  547 40  HOH HOH A . 
C 3 HOH 48  548 18  HOH HOH A . 
C 3 HOH 49  549 55  HOH HOH A . 
C 3 HOH 50  550 178 HOH HOH A . 
C 3 HOH 51  551 23  HOH HOH A . 
C 3 HOH 52  552 25  HOH HOH A . 
C 3 HOH 53  553 128 HOH HOH A . 
C 3 HOH 54  554 176 HOH HOH A . 
C 3 HOH 55  555 35  HOH HOH A . 
C 3 HOH 56  556 37  HOH HOH A . 
C 3 HOH 57  557 2   HOH HOH A . 
C 3 HOH 58  558 34  HOH HOH A . 
C 3 HOH 59  559 8   HOH HOH A . 
C 3 HOH 60  560 30  HOH HOH A . 
C 3 HOH 61  561 11  HOH HOH A . 
C 3 HOH 62  562 19  HOH HOH A . 
C 3 HOH 63  563 16  HOH HOH A . 
C 3 HOH 64  564 7   HOH HOH A . 
C 3 HOH 65  565 121 HOH HOH A . 
C 3 HOH 66  566 81  HOH HOH A . 
C 3 HOH 67  567 161 HOH HOH A . 
C 3 HOH 68  568 82  HOH HOH A . 
C 3 HOH 69  569 54  HOH HOH A . 
C 3 HOH 70  570 150 HOH HOH A . 
C 3 HOH 71  571 102 HOH HOH A . 
C 3 HOH 72  572 26  HOH HOH A . 
C 3 HOH 73  573 90  HOH HOH A . 
C 3 HOH 74  574 123 HOH HOH A . 
C 3 HOH 75  575 138 HOH HOH A . 
C 3 HOH 76  576 85  HOH HOH A . 
C 3 HOH 77  577 160 HOH HOH A . 
C 3 HOH 78  578 112 HOH HOH A . 
C 3 HOH 79  579 63  HOH HOH A . 
C 3 HOH 80  580 117 HOH HOH A . 
C 3 HOH 81  581 72  HOH HOH A . 
C 3 HOH 82  582 32  HOH HOH A . 
C 3 HOH 83  583 21  HOH HOH A . 
C 3 HOH 84  584 4   HOH HOH A . 
C 3 HOH 85  585 120 HOH HOH A . 
C 3 HOH 86  586 167 HOH HOH A . 
C 3 HOH 87  587 108 HOH HOH A . 
C 3 HOH 88  588 29  HOH HOH A . 
C 3 HOH 89  589 31  HOH HOH A . 
C 3 HOH 90  590 142 HOH HOH A . 
C 3 HOH 91  591 22  HOH HOH A . 
C 3 HOH 92  592 132 HOH HOH A . 
C 3 HOH 93  593 38  HOH HOH A . 
C 3 HOH 94  594 83  HOH HOH A . 
C 3 HOH 95  595 71  HOH HOH A . 
C 3 HOH 96  596 130 HOH HOH A . 
C 3 HOH 97  597 17  HOH HOH A . 
C 3 HOH 98  598 74  HOH HOH A . 
C 3 HOH 99  599 89  HOH HOH A . 
C 3 HOH 100 600 9   HOH HOH A . 
C 3 HOH 101 601 88  HOH HOH A . 
C 3 HOH 102 602 28  HOH HOH A . 
C 3 HOH 103 603 156 HOH HOH A . 
C 3 HOH 104 604 115 HOH HOH A . 
C 3 HOH 105 605 36  HOH HOH A . 
C 3 HOH 106 606 152 HOH HOH A . 
C 3 HOH 107 607 171 HOH HOH A . 
C 3 HOH 108 608 155 HOH HOH A . 
C 3 HOH 109 609 70  HOH HOH A . 
C 3 HOH 110 610 177 HOH HOH A . 
C 3 HOH 111 611 6   HOH HOH A . 
C 3 HOH 112 612 98  HOH HOH A . 
C 3 HOH 113 613 87  HOH HOH A . 
C 3 HOH 114 614 172 HOH HOH A . 
C 3 HOH 115 615 96  HOH HOH A . 
C 3 HOH 116 616 56  HOH HOH A . 
C 3 HOH 117 617 147 HOH HOH A . 
C 3 HOH 118 618 91  HOH HOH A . 
C 3 HOH 119 619 65  HOH HOH A . 
C 3 HOH 120 620 119 HOH HOH A . 
C 3 HOH 121 621 51  HOH HOH A . 
C 3 HOH 122 622 53  HOH HOH A . 
C 3 HOH 123 623 45  HOH HOH A . 
C 3 HOH 124 624 64  HOH HOH A . 
C 3 HOH 125 625 145 HOH HOH A . 
C 3 HOH 126 626 80  HOH HOH A . 
C 3 HOH 127 627 164 HOH HOH A . 
C 3 HOH 128 628 44  HOH HOH A . 
C 3 HOH 129 629 159 HOH HOH A . 
C 3 HOH 130 630 168 HOH HOH A . 
C 3 HOH 131 631 133 HOH HOH A . 
C 3 HOH 132 632 154 HOH HOH A . 
C 3 HOH 133 633 151 HOH HOH A . 
C 3 HOH 134 634 175 HOH HOH A . 
C 3 HOH 135 635 127 HOH HOH A . 
C 3 HOH 136 636 174 HOH HOH A . 
C 3 HOH 137 637 60  HOH HOH A . 
C 3 HOH 138 638 97  HOH HOH A . 
C 3 HOH 139 639 116 HOH HOH A . 
C 3 HOH 140 640 136 HOH HOH A . 
C 3 HOH 141 641 62  HOH HOH A . 
C 3 HOH 142 642 57  HOH HOH A . 
C 3 HOH 143 643 165 HOH HOH A . 
C 3 HOH 144 644 157 HOH HOH A . 
C 3 HOH 145 645 107 HOH HOH A . 
C 3 HOH 146 646 131 HOH HOH A . 
C 3 HOH 147 647 59  HOH HOH A . 
C 3 HOH 148 648 158 HOH HOH A . 
C 3 HOH 149 649 75  HOH HOH A . 
C 3 HOH 150 650 148 HOH HOH A . 
C 3 HOH 151 651 162 HOH HOH A . 
C 3 HOH 152 652 12  HOH HOH A . 
C 3 HOH 153 653 144 HOH HOH A . 
C 3 HOH 154 654 61  HOH HOH A . 
C 3 HOH 155 655 110 HOH HOH A . 
C 3 HOH 156 656 129 HOH HOH A . 
C 3 HOH 157 657 169 HOH HOH A . 
C 3 HOH 158 658 27  HOH HOH A . 
C 3 HOH 159 659 99  HOH HOH A . 
C 3 HOH 160 660 143 HOH HOH A . 
C 3 HOH 161 661 139 HOH HOH A . 
C 3 HOH 162 662 109 HOH HOH A . 
C 3 HOH 163 663 137 HOH HOH A . 
C 3 HOH 164 664 20  HOH HOH A . 
C 3 HOH 165 665 58  HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A GLU 47  ? CG  ? A GLU 47  CG  
2  1 Y 1 A GLU 47  ? CD  ? A GLU 47  CD  
3  1 Y 1 A GLU 47  ? OE1 ? A GLU 47  OE1 
4  1 Y 1 A GLU 47  ? OE2 ? A GLU 47  OE2 
5  1 Y 1 A ASN 72  ? CG  ? A ASN 72  CG  
6  1 Y 1 A ASN 72  ? OD1 ? A ASN 72  OD1 
7  1 Y 1 A ASN 72  ? ND2 ? A ASN 72  ND2 
8  1 Y 1 A LYS 100 ? CG  ? A LYS 100 CG  
9  1 Y 1 A LYS 100 ? CD  ? A LYS 100 CD  
10 1 Y 1 A LYS 100 ? CE  ? A LYS 100 CE  
11 1 Y 1 A LYS 100 ? NZ  ? A LYS 100 NZ  
12 1 Y 1 A LYS 102 ? CG  ? A LYS 102 CG  
13 1 Y 1 A LYS 102 ? CD  ? A LYS 102 CD  
14 1 Y 1 A LYS 102 ? CE  ? A LYS 102 CE  
15 1 Y 1 A LYS 102 ? NZ  ? A LYS 102 NZ  
16 1 Y 1 A ARG 217 ? CG  ? A ARG 217 CG  
17 1 Y 1 A ARG 217 ? CD  ? A ARG 217 CD  
18 1 Y 1 A ARG 217 ? NE  ? A ARG 217 NE  
19 1 Y 1 A ARG 217 ? CZ  ? A ARG 217 CZ  
20 1 Y 1 A ARG 217 ? NH1 ? A ARG 217 NH1 
21 1 Y 1 A ARG 217 ? NH2 ? A ARG 217 NH2 
22 1 Y 1 A MET 235 ? CG  ? A MET 235 CG  
23 1 Y 1 A MET 235 ? SD  ? A MET 235 SD  
24 1 Y 1 A MET 235 ? CE  ? A MET 235 CE  
25 1 Y 1 A LYS 236 ? CG  ? A LYS 236 CG  
26 1 Y 1 A LYS 236 ? CD  ? A LYS 236 CD  
27 1 Y 1 A LYS 236 ? CE  ? A LYS 236 CE  
28 1 Y 1 A LYS 236 ? NZ  ? A LYS 236 NZ  
29 1 Y 1 A ASN 277 ? CG  ? A ASN 277 CG  
30 1 Y 1 A ASN 277 ? OD1 ? A ASN 277 OD1 
31 1 Y 1 A ASN 277 ? ND2 ? A ASN 277 ND2 
32 1 Y 1 A ARG 279 ? CG  ? A ARG 279 CG  
33 1 Y 1 A ARG 279 ? CD  ? A ARG 279 CD  
34 1 Y 1 A ARG 279 ? NE  ? A ARG 279 NE  
35 1 Y 1 A ARG 279 ? CZ  ? A ARG 279 CZ  
36 1 Y 1 A ARG 279 ? NH1 ? A ARG 279 NH1 
37 1 Y 1 A ARG 279 ? NH2 ? A ARG 279 NH2 
38 1 Y 1 A PHE 294 ? CG  ? A PHE 294 CG  
39 1 Y 1 A PHE 294 ? CD1 ? A PHE 294 CD1 
40 1 Y 1 A PHE 294 ? CD2 ? A PHE 294 CD2 
41 1 Y 1 A PHE 294 ? CE1 ? A PHE 294 CE1 
42 1 Y 1 A PHE 294 ? CE2 ? A PHE 294 CE2 
43 1 Y 1 A PHE 294 ? CZ  ? A PHE 294 CZ  
44 1 Y 1 A SER 301 ? OG  ? A SER 301 OG  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   101.288 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BO2 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     115.843 
_cell.length_a_esd                 ? 
_cell.length_b                     54.332 
_cell.length_b_esd                 ? 
_cell.length_c                     44.744 
_cell.length_c_esd                 ? 
_cell.volume                       276170.217 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BO2 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y' 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BO2 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.04 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          39.63 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.2 M L-Proline, 0.1 M HEPES, 24% w/v Polyethylene glycol 1,500' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            294 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-11-30 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.920085 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSLS-II BEAMLINE 17-ID-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.920085 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   17-ID-1 
_diffrn_source.pdbx_synchrotron_site       NSLS-II 
# 
_reflns.B_iso_Wilson_estimate                          26.66 
_reflns.entry_id                                       9BO2 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.91 
_reflns.d_resolution_low                               34.16 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     21311 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.74 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          5.65 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.992 
_reflns.pdbx_CC_star                                   0.998 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.91 
_reflns_shell.d_res_low                                     1.978 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           0.97 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2083 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               7.1 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.459 
_reflns_shell.pdbx_CC_star                                  0.793 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          98.39 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               28.77 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9BO2 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.91 
_refine.ls_d_res_low                             34.16 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     21262 
_refine.ls_number_reflns_R_free                  1074 
_refine.ls_number_reflns_R_work                  20188 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.76 
_refine.ls_percent_reflns_R_free                 5.05 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2057 
_refine.ls_R_factor_R_free                       0.2442 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2036 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 26.4829 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2637 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.91 
_refine_hist.d_res_low                        34.16 
_refine_hist.number_atoms_solvent             165 
_refine_hist.number_atoms_total               2494 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2290 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         39 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0023  ? 2403 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.5172  ? 3284 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0406  ? 369  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0032  ? 426  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 11.1877 ? 835  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.91 2.00  . . 128 2494 98.61  . . . . 0.3015 . . . . . . . . . . . 0.3275 
'X-RAY DIFFRACTION' 2.00 2.10  . . 135 2488 99.77  . . . . 0.2684 . . . . . . . . . . . 0.2893 
'X-RAY DIFFRACTION' 2.10 2.23  . . 136 2521 100.00 . . . . 0.2440 . . . . . . . . . . . 0.2851 
'X-RAY DIFFRACTION' 2.23 2.41  . . 127 2516 100.00 . . . . 0.2281 . . . . . . . . . . . 0.2673 
'X-RAY DIFFRACTION' 2.41 2.65  . . 132 2532 99.92  . . . . 0.2281 . . . . . . . . . . . 0.2891 
'X-RAY DIFFRACTION' 2.65 3.03  . . 147 2512 100.00 . . . . 0.2079 . . . . . . . . . . . 0.2632 
'X-RAY DIFFRACTION' 3.03 3.82  . . 145 2520 99.96  . . . . 0.1845 . . . . . . . . . . . 0.2126 
'X-RAY DIFFRACTION' 3.82 34.16 . . 124 2605 99.82  . . . . 0.1659 . . . . . . . . . . . 0.2075 
# 
_struct.entry_id                     9BO2 
_struct.title                        'Crystal Structure of A173V/L50F SARS-CoV-2 Main Protease in Complex with Compound Mpro61' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BO2 
_struct_keywords.text            'Hydrolase, VIRAL PROTEIN' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1AB_SARS2 
_struct_ref.pdbx_db_accession          P0DTD1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_struct_ref.pdbx_align_begin           3264 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9BO2 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 306 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P0DTD1 
_struct_ref_seq.db_align_beg                  3264 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3569 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       306 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9BO2 PHE A 50  ? UNP P0DTD1 LEU 3313 'engineered mutation' 50  1 
1 9BO2 VAL A 173 ? UNP P0DTD1 ALA 3436 'engineered mutation' 173 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2540  ? 
1 MORE         -12   ? 
1 'SSA (A^2)'  24380 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z   1.0000000000  0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000 
2 'crystal symmetry operation' 2_555 -x,y,-z -1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 10  ? GLY A 15  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 41  ? CYS A 44  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 THR A 45  ? MET A 49  ? THR A 45  MET A 49  5 ? 5  
HELX_P HELX_P4  AA4 ASN A 53  ? ARG A 60  ? ASN A 53  ARG A 60  1 ? 8  
HELX_P HELX_P5  AA5 LYS A 61  ? HIS A 64  ? LYS A 61  HIS A 64  5 ? 4  
HELX_P HELX_P6  AA6 ILE A 200 ? ASN A 214 ? ILE A 200 ASN A 214 1 ? 15 
HELX_P HELX_P7  AA7 THR A 226 ? TYR A 237 ? THR A 226 TYR A 237 1 ? 12 
HELX_P HELX_P8  AA8 THR A 243 ? LEU A 250 ? THR A 243 LEU A 250 1 ? 8  
HELX_P HELX_P9  AA9 LEU A 250 ? GLY A 258 ? LEU A 250 GLY A 258 1 ? 9  
HELX_P HELX_P10 AB1 ALA A 260 ? GLY A 275 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P11 AB2 THR A 292 ? CYS A 300 ? THR A 292 CYS A 300 1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 73  ? LEU A 75  ? VAL A 73  LEU A 75  
AA1 2 PHE A 66  ? ALA A 70  ? PHE A 66  ALA A 70  
AA1 3 MET A 17  ? CYS A 22  ? MET A 17  CYS A 22  
AA1 4 THR A 25  ? LEU A 32  ? THR A 25  LEU A 32  
AA1 5 VAL A 35  ? PRO A 39  ? VAL A 35  PRO A 39  
AA1 6 VAL A 86  ? VAL A 91  ? VAL A 86  VAL A 91  
AA1 7 VAL A 77  ? GLN A 83  ? VAL A 77  GLN A 83  
AA2 1 LYS A 100 ? PHE A 103 ? LYS A 100 PHE A 103 
AA2 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA2 3 VAL A 148 ? ASP A 153 ? VAL A 148 ASP A 153 
AA2 4 THR A 111 ? TYR A 118 ? THR A 111 TYR A 118 
AA2 5 SER A 121 ? ALA A 129 ? SER A 121 ALA A 129 
AA3 1 LYS A 100 ? PHE A 103 ? LYS A 100 PHE A 103 
AA3 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA3 3 HIS A 172 ? THR A 175 ? HIS A 172 THR A 175 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL A 73  ? O VAL A 73  N ALA A 70  ? N ALA A 70  
AA1 2 3 O LEU A 67  ? O LEU A 67  N THR A 21  ? N THR A 21  
AA1 3 4 N VAL A 20  ? N VAL A 20  O LEU A 27  ? O LEU A 27  
AA1 4 5 N LEU A 30  ? N LEU A 30  O TYR A 37  ? O TYR A 37  
AA1 5 6 N CYS A 38  ? N CYS A 38  O LEU A 87  ? O LEU A 87  
AA1 6 7 O LYS A 88  ? O LYS A 88  N SER A 81  ? N SER A 81  
AA2 1 2 N LYS A 100 ? N LYS A 100 O VAL A 157 ? O VAL A 157 
AA2 2 3 O SER A 158 ? O SER A 158 N ASN A 151 ? N ASN A 151 
AA2 3 4 O PHE A 150 ? O PHE A 150 N SER A 113 ? N SER A 113 
AA2 4 5 N ALA A 116 ? N ALA A 116 O SER A 123 ? O SER A 123 
AA3 1 2 N LYS A 100 ? N LYS A 100 O VAL A 157 ? O VAL A 157 
AA3 2 3 N MET A 165 ? N MET A 165 O VAL A 173 ? O VAL A 173 
# 
_pdbx_entry_details.entry_id                   9BO2 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 33  ? ? 54.65   -129.24 
2 1 ASN A 51  ? ? -153.87 72.99   
3 1 ASN A 84  ? ? 57.58   -127.43 
4 1 TYR A 154 ? ? 57.54   -92.44  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 -x,y,-z         
3 x+1/2,y+1/2,z   
4 -x+1/2,y+1/2,-z 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A GLY 302 ? A GLY 302 
2 1 Y 1 A VAL 303 ? A VAL 303 
3 1 Y 1 A THR 304 ? A THR 304 
4 1 Y 1 A PHE 305 ? A PHE 305 
5 1 Y 1 A GLN 306 ? A GLN 306 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
GLN N    N  N N 88  
GLN CA   C  N S 89  
GLN C    C  N N 90  
GLN O    O  N N 91  
GLN CB   C  N N 92  
GLN CG   C  N N 93  
GLN CD   C  N N 94  
GLN OE1  O  N N 95  
GLN NE2  N  N N 96  
GLN OXT  O  N N 97  
GLN H    H  N N 98  
GLN H2   H  N N 99  
GLN HA   H  N N 100 
GLN HB2  H  N N 101 
GLN HB3  H  N N 102 
GLN HG2  H  N N 103 
GLN HG3  H  N N 104 
GLN HE21 H  N N 105 
GLN HE22 H  N N 106 
GLN HXT  H  N N 107 
GLU N    N  N N 108 
GLU CA   C  N S 109 
GLU C    C  N N 110 
GLU O    O  N N 111 
GLU CB   C  N N 112 
GLU CG   C  N N 113 
GLU CD   C  N N 114 
GLU OE1  O  N N 115 
GLU OE2  O  N N 116 
GLU OXT  O  N N 117 
GLU H    H  N N 118 
GLU H2   H  N N 119 
GLU HA   H  N N 120 
GLU HB2  H  N N 121 
GLU HB3  H  N N 122 
GLU HG2  H  N N 123 
GLU HG3  H  N N 124 
GLU HE2  H  N N 125 
GLU HXT  H  N N 126 
GLY N    N  N N 127 
GLY CA   C  N N 128 
GLY C    C  N N 129 
GLY O    O  N N 130 
GLY OXT  O  N N 131 
GLY H    H  N N 132 
GLY H2   H  N N 133 
GLY HA2  H  N N 134 
GLY HA3  H  N N 135 
GLY HXT  H  N N 136 
HIS N    N  N N 137 
HIS CA   C  N S 138 
HIS C    C  N N 139 
HIS O    O  N N 140 
HIS CB   C  N N 141 
HIS CG   C  Y N 142 
HIS ND1  N  Y N 143 
HIS CD2  C  Y N 144 
HIS CE1  C  Y N 145 
HIS NE2  N  Y N 146 
HIS OXT  O  N N 147 
HIS H    H  N N 148 
HIS H2   H  N N 149 
HIS HA   H  N N 150 
HIS HB2  H  N N 151 
HIS HB3  H  N N 152 
HIS HD1  H  N N 153 
HIS HD2  H  N N 154 
HIS HE1  H  N N 155 
HIS HE2  H  N N 156 
HIS HXT  H  N N 157 
HOH O    O  N N 158 
HOH H1   H  N N 159 
HOH H2   H  N N 160 
ILE N    N  N N 161 
ILE CA   C  N S 162 
ILE C    C  N N 163 
ILE O    O  N N 164 
ILE CB   C  N S 165 
ILE CG1  C  N N 166 
ILE CG2  C  N N 167 
ILE CD1  C  N N 168 
ILE OXT  O  N N 169 
ILE H    H  N N 170 
ILE H2   H  N N 171 
ILE HA   H  N N 172 
ILE HB   H  N N 173 
ILE HG12 H  N N 174 
ILE HG13 H  N N 175 
ILE HG21 H  N N 176 
ILE HG22 H  N N 177 
ILE HG23 H  N N 178 
ILE HD11 H  N N 179 
ILE HD12 H  N N 180 
ILE HD13 H  N N 181 
ILE HXT  H  N N 182 
LEU N    N  N N 183 
LEU CA   C  N S 184 
LEU C    C  N N 185 
LEU O    O  N N 186 
LEU CB   C  N N 187 
LEU CG   C  N N 188 
LEU CD1  C  N N 189 
LEU CD2  C  N N 190 
LEU OXT  O  N N 191 
LEU H    H  N N 192 
LEU H2   H  N N 193 
LEU HA   H  N N 194 
LEU HB2  H  N N 195 
LEU HB3  H  N N 196 
LEU HG   H  N N 197 
LEU HD11 H  N N 198 
LEU HD12 H  N N 199 
LEU HD13 H  N N 200 
LEU HD21 H  N N 201 
LEU HD22 H  N N 202 
LEU HD23 H  N N 203 
LEU HXT  H  N N 204 
LYS N    N  N N 205 
LYS CA   C  N S 206 
LYS C    C  N N 207 
LYS O    O  N N 208 
LYS CB   C  N N 209 
LYS CG   C  N N 210 
LYS CD   C  N N 211 
LYS CE   C  N N 212 
LYS NZ   N  N N 213 
LYS OXT  O  N N 214 
LYS H    H  N N 215 
LYS H2   H  N N 216 
LYS HA   H  N N 217 
LYS HB2  H  N N 218 
LYS HB3  H  N N 219 
LYS HG2  H  N N 220 
LYS HG3  H  N N 221 
LYS HD2  H  N N 222 
LYS HD3  H  N N 223 
LYS HE2  H  N N 224 
LYS HE3  H  N N 225 
LYS HZ1  H  N N 226 
LYS HZ2  H  N N 227 
LYS HZ3  H  N N 228 
LYS HXT  H  N N 229 
MET N    N  N N 230 
MET CA   C  N S 231 
MET C    C  N N 232 
MET O    O  N N 233 
MET CB   C  N N 234 
MET CG   C  N N 235 
MET SD   S  N N 236 
MET CE   C  N N 237 
MET OXT  O  N N 238 
MET H    H  N N 239 
MET H2   H  N N 240 
MET HA   H  N N 241 
MET HB2  H  N N 242 
MET HB3  H  N N 243 
MET HG2  H  N N 244 
MET HG3  H  N N 245 
MET HE1  H  N N 246 
MET HE2  H  N N 247 
MET HE3  H  N N 248 
MET HXT  H  N N 249 
PHE N    N  N N 250 
PHE CA   C  N S 251 
PHE C    C  N N 252 
PHE O    O  N N 253 
PHE CB   C  N N 254 
PHE CG   C  Y N 255 
PHE CD1  C  Y N 256 
PHE CD2  C  Y N 257 
PHE CE1  C  Y N 258 
PHE CE2  C  Y N 259 
PHE CZ   C  Y N 260 
PHE OXT  O  N N 261 
PHE H    H  N N 262 
PHE H2   H  N N 263 
PHE HA   H  N N 264 
PHE HB2  H  N N 265 
PHE HB3  H  N N 266 
PHE HD1  H  N N 267 
PHE HD2  H  N N 268 
PHE HE1  H  N N 269 
PHE HE2  H  N N 270 
PHE HZ   H  N N 271 
PHE HXT  H  N N 272 
PRO N    N  N N 273 
PRO CA   C  N S 274 
PRO C    C  N N 275 
PRO O    O  N N 276 
PRO CB   C  N N 277 
PRO CG   C  N N 278 
PRO CD   C  N N 279 
PRO OXT  O  N N 280 
PRO H    H  N N 281 
PRO HA   H  N N 282 
PRO HB2  H  N N 283 
PRO HB3  H  N N 284 
PRO HG2  H  N N 285 
PRO HG3  H  N N 286 
PRO HD2  H  N N 287 
PRO HD3  H  N N 288 
PRO HXT  H  N N 289 
SER N    N  N N 290 
SER CA   C  N S 291 
SER C    C  N N 292 
SER O    O  N N 293 
SER CB   C  N N 294 
SER OG   O  N N 295 
SER OXT  O  N N 296 
SER H    H  N N 297 
SER H2   H  N N 298 
SER HA   H  N N 299 
SER HB2  H  N N 300 
SER HB3  H  N N 301 
SER HG   H  N N 302 
SER HXT  H  N N 303 
THR N    N  N N 304 
THR CA   C  N S 305 
THR C    C  N N 306 
THR O    O  N N 307 
THR CB   C  N R 308 
THR OG1  O  N N 309 
THR CG2  C  N N 310 
THR OXT  O  N N 311 
THR H    H  N N 312 
THR H2   H  N N 313 
THR HA   H  N N 314 
THR HB   H  N N 315 
THR HG1  H  N N 316 
THR HG21 H  N N 317 
THR HG22 H  N N 318 
THR HG23 H  N N 319 
THR HXT  H  N N 320 
TRP N    N  N N 321 
TRP CA   C  N S 322 
TRP C    C  N N 323 
TRP O    O  N N 324 
TRP CB   C  N N 325 
TRP CG   C  Y N 326 
TRP CD1  C  Y N 327 
TRP CD2  C  Y N 328 
TRP NE1  N  Y N 329 
TRP CE2  C  Y N 330 
TRP CE3  C  Y N 331 
TRP CZ2  C  Y N 332 
TRP CZ3  C  Y N 333 
TRP CH2  C  Y N 334 
TRP OXT  O  N N 335 
TRP H    H  N N 336 
TRP H2   H  N N 337 
TRP HA   H  N N 338 
TRP HB2  H  N N 339 
TRP HB3  H  N N 340 
TRP HD1  H  N N 341 
TRP HE1  H  N N 342 
TRP HE3  H  N N 343 
TRP HZ2  H  N N 344 
TRP HZ3  H  N N 345 
TRP HH2  H  N N 346 
TRP HXT  H  N N 347 
TYR N    N  N N 348 
TYR CA   C  N S 349 
TYR C    C  N N 350 
TYR O    O  N N 351 
TYR CB   C  N N 352 
TYR CG   C  Y N 353 
TYR CD1  C  Y N 354 
TYR CD2  C  Y N 355 
TYR CE1  C  Y N 356 
TYR CE2  C  Y N 357 
TYR CZ   C  Y N 358 
TYR OH   O  N N 359 
TYR OXT  O  N N 360 
TYR H    H  N N 361 
TYR H2   H  N N 362 
TYR HA   H  N N 363 
TYR HB2  H  N N 364 
TYR HB3  H  N N 365 
TYR HD1  H  N N 366 
TYR HD2  H  N N 367 
TYR HE1  H  N N 368 
TYR HE2  H  N N 369 
TYR HH   H  N N 370 
TYR HXT  H  N N 371 
VAL N    N  N N 372 
VAL CA   C  N S 373 
VAL C    C  N N 374 
VAL O    O  N N 375 
VAL CB   C  N N 376 
VAL CG1  C  N N 377 
VAL CG2  C  N N 378 
VAL OXT  O  N N 379 
VAL H    H  N N 380 
VAL H2   H  N N 381 
VAL HA   H  N N 382 
VAL HB   H  N N 383 
VAL HG11 H  N N 384 
VAL HG12 H  N N 385 
VAL HG13 H  N N 386 
VAL HG21 H  N N 387 
VAL HG22 H  N N 388 
VAL HG23 H  N N 389 
VAL HXT  H  N N 390 
XEK C1   C  N N 391 
XEK C2   C  N N 392 
XEK C3   C  Y N 393 
XEK C4   C  Y N 394 
XEK C5   C  Y N 395 
XEK C6   C  Y N 396 
XEK C7   C  Y N 397 
XEK C8   C  N N 398 
XEK C9   C  Y N 399 
XEK C10  C  Y N 400 
XEK C11  C  Y N 401 
XEK C12  C  Y N 402 
XEK C13  C  Y N 403 
XEK C14  C  Y N 404 
XEK C15  C  Y N 405 
XEK C17  C  N N 406 
XEK C21  C  N N 407 
XEK C22  C  N N 408 
XEK C24  C  Y N 409 
XEK C25  C  Y N 410 
XEK C27  C  Y N 411 
XEK C16  C  N N 412 
XEK C18  C  N N 413 
XEK C19  C  N N 414 
XEK C20  C  N N 415 
XEK C23  C  N N 416 
XEK C26  C  Y N 417 
XEK C28  C  Y N 418 
XEK F1   F  N N 419 
XEK N1   N  N N 420 
XEK N2   N  N N 421 
XEK N3   N  N N 422 
XEK N4   N  Y N 423 
XEK O1   O  N N 424 
XEK O2   O  N N 425 
XEK O3   O  N N 426 
XEK O4   O  N N 427 
XEK CL1  CL N N 428 
XEK CL2  CL N N 429 
XEK H1   H  N N 430 
XEK H2   H  N N 431 
XEK H3   H  N N 432 
XEK H4   H  N N 433 
XEK H5   H  N N 434 
XEK H6   H  N N 435 
XEK H7   H  N N 436 
XEK H8   H  N N 437 
XEK H13  H  N N 438 
XEK H14  H  N N 439 
XEK H12  H  N N 440 
XEK H16  H  N N 441 
XEK H18  H  N N 442 
XEK H9   H  N N 443 
XEK H11  H  N N 444 
XEK H15  H  N N 445 
XEK H17  H  N N 446 
XEK H19  H  N N 447 
XEK H10  H  N N 448 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
XEK O1  C1   doub N N 376 
XEK C1  C2   sing N N 377 
XEK C1  N3   sing N N 378 
XEK C2  C3   sing N N 379 
XEK C2  C16  doub N N 380 
XEK C3  C4   doub Y N 381 
XEK C3  C15  sing Y N 382 
XEK C4  C5   sing Y N 383 
XEK C5  CL1  sing N N 384 
XEK C5  C6   doub Y N 385 
XEK C6  F1   sing N N 386 
XEK C6  C7   sing Y N 387 
XEK C7  O2   sing N N 388 
XEK C7  C15  doub Y N 389 
XEK O2  C8   sing N N 390 
XEK C8  C9   sing N N 391 
XEK C9  C10  doub Y N 392 
XEK C9  C14  sing Y N 393 
XEK C10 C11  sing Y N 394 
XEK C11 C12  doub Y N 395 
XEK C12 C13  sing Y N 396 
XEK C13 C14  doub Y N 397 
XEK C14 CL2  sing N N 398 
XEK C16 C17  sing N N 399 
XEK C17 C18  sing N N 400 
XEK C17 C23  doub N N 401 
XEK C18 C19  sing N N 402 
XEK C18 C20  doub N N 403 
XEK C19 N1   sing N N 404 
XEK C19 O3   doub N N 405 
XEK N1  C22  sing N N 406 
XEK C20 N2   sing N N 407 
XEK N2  C21  sing N N 408 
XEK N2  C22  sing N N 409 
XEK C22 O4   doub N N 410 
XEK C23 N3   sing N N 411 
XEK N3  C24  sing N N 412 
XEK C24 C25  doub Y N 413 
XEK C24 C28  sing Y N 414 
XEK C25 C26  sing Y N 415 
XEK C26 C27  doub Y N 416 
XEK C27 N4   sing Y N 417 
XEK N4  C28  doub Y N 418 
XEK C4  H1   sing N N 419 
XEK C8  H2   sing N N 420 
XEK C8  H3   sing N N 421 
XEK C10 H4   sing N N 422 
XEK C11 H5   sing N N 423 
XEK C12 H6   sing N N 424 
XEK C13 H7   sing N N 425 
XEK C15 H8   sing N N 426 
XEK C21 H13  sing N N 427 
XEK C21 H14  sing N N 428 
XEK C21 H12  sing N N 429 
XEK C25 H16  sing N N 430 
XEK C27 H18  sing N N 431 
XEK C16 H9   sing N N 432 
XEK C20 H11  sing N N 433 
XEK C23 H15  sing N N 434 
XEK C26 H17  sing N N 435 
XEK C28 H19  sing N N 436 
XEK N1  H10  sing N N 437 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' 'P30 GM133893' 1 
'Department of Energy (DOE, United States)'                                                'United States' KP1607011      2 
'Other government'                                                                         ?               DE-SC0012704   3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6Y2F 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'C 1 2 1' 
_space_group.name_Hall        'C 2y' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9BO2 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.008632 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.001723 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.018405 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.022790 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
CL ? ? 9.50761 7.44341 ? ? 1.04373  23.83732 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
F  ? ? 4.90428 4.07044 ? ? 12.99538 1.63651  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H  ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . SER A 1 1   ? -3.05732 5.59912   -16.75140 1.000 30.77154 ? 1   SER A N   1 
ATOM   2    C  CA  . SER A 1 1   ? -2.39370 6.76198   -16.17593 1.000 30.72500 ? 1   SER A CA  1 
ATOM   3    C  C   . SER A 1 1   ? -2.70883 6.88446   -14.68740 1.000 33.95580 ? 1   SER A C   1 
ATOM   4    O  O   . SER A 1 1   ? -3.34049 6.00279   -14.10436 1.000 33.65031 ? 1   SER A O   1 
ATOM   5    C  CB  . SER A 1 1   ? -2.80097 8.04028   -16.91859 1.000 36.71728 ? 1   SER A CB  1 
ATOM   6    O  OG  . SER A 1 1   ? -4.20158 8.24535   -16.86537 1.000 34.98786 ? 1   SER A OG  1 
ATOM   7    N  N   . GLY A 1 2   ? -2.26898 7.98074   -14.08275 1.000 32.45599 ? 2   GLY A N   1 
ATOM   8    C  CA  . GLY A 1 2   ? -2.35600 8.16851   -12.65113 1.000 29.77035 ? 2   GLY A CA  1 
ATOM   9    C  C   . GLY A 1 2   ? -1.06706 7.76981   -11.95035 1.000 31.50228 ? 2   GLY A C   1 
ATOM   10   O  O   . GLY A 1 2   ? -0.27286 6.96415   -12.44221 1.000 34.56025 ? 2   GLY A O   1 
ATOM   11   N  N   . PHE A 1 3   ? -0.85141 8.35684   -10.77344 1.000 32.82816 ? 3   PHE A N   1 
ATOM   12   C  CA  . PHE A 1 3   ? 0.34438  8.07125   -9.99137  1.000 30.82381 ? 3   PHE A CA  1 
ATOM   13   C  C   . PHE A 1 3   ? -0.02415 7.97956   -8.52054  1.000 32.14225 ? 3   PHE A C   1 
ATOM   14   O  O   . PHE A 1 3   ? -0.66300 8.88525   -7.97684  1.000 35.53808 ? 3   PHE A O   1 
ATOM   15   C  CB  . PHE A 1 3   ? 1.42339  9.13926   -10.20382 1.000 33.78465 ? 3   PHE A CB  1 
ATOM   16   C  CG  . PHE A 1 3   ? 2.81323  8.66327   -9.88823  1.000 31.22456 ? 3   PHE A CG  1 
ATOM   17   C  CD1 . PHE A 1 3   ? 3.47521  7.80338   -10.75249 1.000 32.92329 ? 3   PHE A CD1 1 
ATOM   18   C  CD2 . PHE A 1 3   ? 3.45596  9.07012   -8.73099  1.000 31.41524 ? 3   PHE A CD2 1 
ATOM   19   C  CE1 . PHE A 1 3   ? 4.75402  7.35973   -10.47060 1.000 34.14521 ? 3   PHE A CE1 1 
ATOM   20   C  CE2 . PHE A 1 3   ? 4.73494  8.62959   -8.44124  1.000 30.30384 ? 3   PHE A CE2 1 
ATOM   21   C  CZ  . PHE A 1 3   ? 5.38420  7.77284   -9.31122  1.000 28.56859 ? 3   PHE A CZ  1 
ATOM   22   N  N   . ARG A 1 4   ? 0.38814  6.88741   -7.88410  1.000 30.42617 ? 4   ARG A N   1 
ATOM   23   C  CA  . ARG A 1 4   ? 0.05034  6.61484   -6.49805  1.000 30.54783 ? 4   ARG A CA  1 
ATOM   24   C  C   . ARG A 1 4   ? 1.27166  6.07434   -5.77130  1.000 26.92594 ? 4   ARG A C   1 
ATOM   25   O  O   . ARG A 1 4   ? 2.17503  5.50366   -6.38513  1.000 27.31266 ? 4   ARG A O   1 
ATOM   26   C  CB  . ARG A 1 4   ? -1.10607 5.61238   -6.40285  1.000 30.35431 ? 4   ARG A CB  1 
ATOM   27   C  CG  . ARG A 1 4   ? -2.47184 6.25836   -6.44291  1.000 32.02198 ? 4   ARG A CG  1 
ATOM   28   C  CD  . ARG A 1 4   ? -2.70634 7.05420   -5.17103  1.000 32.40867 ? 4   ARG A CD  1 
ATOM   29   N  NE  . ARG A 1 4   ? -4.04431 7.62734   -5.12835  1.000 41.74608 ? 4   ARG A NE  1 
ATOM   30   C  CZ  . ARG A 1 4   ? -5.14674 6.92380   -4.91295  1.000 38.36770 ? 4   ARG A CZ  1 
ATOM   31   N  NH1 . ARG A 1 4   ? -5.10511 5.61323   -4.73847  1.000 34.31087 ? 4   ARG A NH1 1 
ATOM   32   N  NH2 . ARG A 1 4   ? -6.32122 7.54937   -4.88197  1.000 39.53131 ? 4   ARG A NH2 1 
ATOM   33   N  N   . LYS A 1 5   ? 1.29311  6.26215   -4.45468  1.000 28.80001 ? 5   LYS A N   1 
ATOM   34   C  CA  . LYS A 1 5   ? 2.32554  5.66013   -3.61514  1.000 28.12307 ? 5   LYS A CA  1 
ATOM   35   C  C   . LYS A 1 5   ? 1.96971  4.18890   -3.45076  1.000 28.16085 ? 5   LYS A C   1 
ATOM   36   O  O   . LYS A 1 5   ? 1.05342  3.83257   -2.70748  1.000 29.54272 ? 5   LYS A O   1 
ATOM   37   C  CB  . LYS A 1 5   ? 2.42464  6.37827   -2.27575  1.000 30.25259 ? 5   LYS A CB  1 
ATOM   38   C  CG  . LYS A 1 5   ? 3.62734  5.96266   -1.44469  1.000 29.73847 ? 5   LYS A CG  1 
ATOM   39   C  CD  . LYS A 1 5   ? 3.92623  6.98985   -0.36703  1.000 35.33409 ? 5   LYS A CD  1 
ATOM   40   C  CE  . LYS A 1 5   ? 4.39632  8.29873   -0.97827  1.000 35.02767 ? 5   LYS A CE  1 
ATOM   41   N  NZ  . LYS A 1 5   ? 4.65990  9.33050   0.06337   1.000 38.20750 ? 5   LYS A NZ  1 
ATOM   42   N  N   . MET A 1 6   ? 2.69375  3.33203   -4.15775  1.000 23.57751 ? 6   MET A N   1 
ATOM   43   C  CA  . MET A 1 6   ? 2.30333  1.94842   -4.37396  1.000 25.09660 ? 6   MET A CA  1 
ATOM   44   C  C   . MET A 1 6   ? 3.27683  1.01669   -3.66805  1.000 23.10896 ? 6   MET A C   1 
ATOM   45   O  O   . MET A 1 6   ? 4.49574  1.15773   -3.81230  1.000 26.05867 ? 6   MET A O   1 
ATOM   46   C  CB  . MET A 1 6   ? 2.26574  1.64455   -5.87324  1.000 28.17025 ? 6   MET A CB  1 
ATOM   47   C  CG  . MET A 1 6   ? 1.60886  0.34097   -6.25064  1.000 32.71134 ? 6   MET A CG  1 
ATOM   48   S  SD  . MET A 1 6   ? 1.52495  0.19968   -8.04512  1.000 38.53299 ? 6   MET A SD  1 
ATOM   49   C  CE  . MET A 1 6   ? 0.59976  1.68129   -8.44587  1.000 31.98571 ? 6   MET A CE  1 
ATOM   50   N  N   . ALA A 1 7   ? 2.73729  0.06557   -2.91751  1.000 24.37704 ? 7   ALA A N   1 
ATOM   51   C  CA  . ALA A 1 7   ? 3.53032  -0.94541  -2.23707  1.000 25.08263 ? 7   ALA A CA  1 
ATOM   52   C  C   . ALA A 1 7   ? 3.61209  -2.21583  -3.07657  1.000 26.57410 ? 7   ALA A C   1 
ATOM   53   O  O   . ALA A 1 7   ? 2.79064  -2.45601  -3.96569  1.000 23.85814 ? 7   ALA A O   1 
ATOM   54   C  CB  . ALA A 1 7   ? 2.93249  -1.26501  -0.86647  1.000 23.29116 ? 7   ALA A CB  1 
ATOM   55   N  N   . PHE A 1 8   ? 4.62342  -3.03151  -2.78594  1.000 25.53365 ? 8   PHE A N   1 
ATOM   56   C  CA  . PHE A 1 8   ? 4.70368  -4.34138  -3.40947  1.000 23.98156 ? 8   PHE A CA  1 
ATOM   57   C  C   . PHE A 1 8   ? 3.61473  -5.25312  -2.84993  1.000 23.78420 ? 8   PHE A C   1 
ATOM   58   O  O   . PHE A 1 8   ? 3.19536  -5.09599  -1.69968  1.000 22.37586 ? 8   PHE A O   1 
ATOM   59   C  CB  . PHE A 1 8   ? 6.06583  -4.98247  -3.16705  1.000 22.88684 ? 8   PHE A CB  1 
ATOM   60   C  CG  . PHE A 1 8   ? 7.18963  -4.31115  -3.89009  1.000 25.75810 ? 8   PHE A CG  1 
ATOM   61   C  CD1 . PHE A 1 8   ? 7.40211  -4.54824  -5.23737  1.000 28.71060 ? 8   PHE A CD1 1 
ATOM   62   C  CD2 . PHE A 1 8   ? 8.04282  -3.45156  -3.22170  1.000 26.44882 ? 8   PHE A CD2 1 
ATOM   63   C  CE1 . PHE A 1 8   ? 8.44084  -3.93120  -5.90762  1.000 29.57166 ? 8   PHE A CE1 1 
ATOM   64   C  CE2 . PHE A 1 8   ? 9.08428  -2.83139  -3.88724  1.000 28.42200 ? 8   PHE A CE2 1 
ATOM   65   C  CZ  . PHE A 1 8   ? 9.28378  -3.07272  -5.22933  1.000 31.30040 ? 8   PHE A CZ  1 
ATOM   66   N  N   . PRO A 1 9   ? 3.14849  -6.22182  -3.63777  1.000 23.98393 ? 9   PRO A N   1 
ATOM   67   C  CA  . PRO A 1 9   ? 2.24342  -7.23530  -3.08429  1.000 23.89824 ? 9   PRO A CA  1 
ATOM   68   C  C   . PRO A 1 9   ? 2.93343  -7.95826  -1.93829  1.000 21.89465 ? 9   PRO A C   1 
ATOM   69   O  O   . PRO A 1 9   ? 4.09027  -8.36905  -2.05197  1.000 25.86193 ? 9   PRO A O   1 
ATOM   70   C  CB  . PRO A 1 9   ? 1.97260  -8.16754  -4.27336  1.000 24.16220 ? 9   PRO A CB  1 
ATOM   71   C  CG  . PRO A 1 9   ? 2.35020  -7.36721  -5.49579  1.000 27.85384 ? 9   PRO A CG  1 
ATOM   72   C  CD  . PRO A 1 9   ? 3.47340  -6.47730  -5.05142  1.000 24.24805 ? 9   PRO A CD  1 
ATOM   73   N  N   . SER A 1 10  ? 2.22069  -8.09649  -0.82314  1.000 23.62627 ? 10  SER A N   1 
ATOM   74   C  CA  . SER A 1 10  ? 2.82201  -8.54030  0.42935   1.000 26.90482 ? 10  SER A CA  1 
ATOM   75   C  C   . SER A 1 10  ? 2.67213  -10.03462 0.68261   1.000 24.32104 ? 10  SER A C   1 
ATOM   76   O  O   . SER A 1 10  ? 3.14341  -10.51802 1.71646   1.000 22.54839 ? 10  SER A O   1 
ATOM   77   C  CB  . SER A 1 10  ? 2.21913  -7.76236  1.60717   1.000 24.62073 ? 10  SER A CB  1 
ATOM   78   O  OG  . SER A 1 10  ? 0.81483  -7.95698  1.69931   1.000 26.01110 ? 10  SER A OG  1 
ATOM   79   N  N   . GLY A 1 11  ? 2.04303  -10.77667 -0.23073  1.000 23.79283 ? 11  GLY A N   1 
ATOM   80   C  CA  . GLY A 1 11  ? 1.75634  -12.17803 0.04299   1.000 23.41115 ? 11  GLY A CA  1 
ATOM   81   C  C   . GLY A 1 11  ? 2.99201  -12.97942 0.40930   1.000 22.70895 ? 11  GLY A C   1 
ATOM   82   O  O   . GLY A 1 11  ? 2.98729  -13.74584 1.37664   1.000 23.68849 ? 11  GLY A O   1 
ATOM   83   N  N   . LYS A 1 12  ? 4.06754  -12.82264 -0.36632  1.000 22.34335 ? 12  LYS A N   1 
ATOM   84   C  CA  . LYS A 1 12  ? 5.27297  -13.60851 -0.11851  1.000 26.24372 ? 12  LYS A CA  1 
ATOM   85   C  C   . LYS A 1 12  ? 5.81925  -13.38241 1.28535   1.000 24.37968 ? 12  LYS A C   1 
ATOM   86   O  O   . LYS A 1 12  ? 6.40323  -14.29743 1.87887   1.000 24.28121 ? 12  LYS A O   1 
ATOM   87   C  CB  . LYS A 1 12  ? 6.33894  -13.27552 -1.16116  1.000 26.12421 ? 12  LYS A CB  1 
ATOM   88   C  CG  . LYS A 1 12  ? 6.01779  -13.78414 -2.55588  1.000 31.25518 ? 12  LYS A CG  1 
ATOM   89   C  CD  . LYS A 1 12  ? 6.91759  -13.13264 -3.59005  1.000 31.08820 ? 12  LYS A CD  1 
ATOM   90   C  CE  . LYS A 1 12  ? 6.67297  -13.69991 -4.97618  1.000 35.82961 ? 12  LYS A CE  1 
ATOM   91   N  NZ  . LYS A 1 12  ? 7.15410  -15.10406 -5.08380  1.000 37.49306 ? 12  LYS A NZ  1 
ATOM   92   N  N   . VAL A 1 13  ? 5.64775  -12.18068 1.82971   1.000 21.51254 ? 13  VAL A N   1 
ATOM   93   C  CA  . VAL A 1 13  ? 6.15352  -11.89522 3.16567   1.000 22.28545 ? 13  VAL A CA  1 
ATOM   94   C  C   . VAL A 1 13  ? 5.16030  -12.30864 4.24648   1.000 23.97294 ? 13  VAL A C   1 
ATOM   95   O  O   . VAL A 1 13  ? 5.57328  -12.74264 5.32635   1.000 23.97946 ? 13  VAL A O   1 
ATOM   96   C  CB  . VAL A 1 13  ? 6.51734  -10.40681 3.29445   1.000 23.38474 ? 13  VAL A CB  1 
ATOM   97   C  CG1 . VAL A 1 13  ? 7.04311  -10.11046 4.69368   1.000 25.33323 ? 13  VAL A CG1 1 
ATOM   98   C  CG2 . VAL A 1 13  ? 7.54136  -10.02171 2.23848   1.000 21.80449 ? 13  VAL A CG2 1 
ATOM   99   N  N   . GLU A 1 14  ? 3.85648  -12.18204 3.98252   1.000 22.33072 ? 14  GLU A N   1 
ATOM   100  C  CA  . GLU A 1 14  ? 2.86376  -12.59880 4.96609   1.000 23.91713 ? 14  GLU A CA  1 
ATOM   101  C  C   . GLU A 1 14  ? 3.11032  -14.03082 5.41745   1.000 23.09932 ? 14  GLU A C   1 
ATOM   102  O  O   . GLU A 1 14  ? 2.97259  -14.34853 6.60394   1.000 25.63347 ? 14  GLU A O   1 
ATOM   103  C  CB  . GLU A 1 14  ? 1.45324  -12.45717 4.38925   1.000 23.68917 ? 14  GLU A CB  1 
ATOM   104  C  CG  . GLU A 1 14  ? 1.08716  -11.04588 3.95927   1.000 23.25516 ? 14  GLU A CG  1 
ATOM   105  C  CD  . GLU A 1 14  ? -0.23448 -10.99202 3.21139   1.000 26.32902 ? 14  GLU A CD  1 
ATOM   106  O  OE1 . GLU A 1 14  ? -1.13857 -11.79153 3.53383   1.000 24.38962 ? 14  GLU A OE1 1 
ATOM   107  O  OE2 . GLU A 1 14  ? -0.36560 -10.15612 2.29453   1.000 24.80011 ? 14  GLU A OE2 1 
ATOM   108  N  N   . GLY A 1 15  ? 3.48854  -14.90754 4.48584   1.000 25.09771 ? 15  GLY A N   1 
ATOM   109  C  CA  . GLY A 1 15  ? 3.75633  -16.29515 4.81559   1.000 26.76952 ? 15  GLY A CA  1 
ATOM   110  C  C   . GLY A 1 15  ? 5.00438  -16.53664 5.63740   1.000 27.57277 ? 15  GLY A C   1 
ATOM   111  O  O   . GLY A 1 15  ? 5.26324  -17.68283 6.01615   1.000 24.97600 ? 15  GLY A O   1 
ATOM   112  N  N   . CYS A 1 16  ? 5.78925  -15.49529 5.91845   1.000 23.83493 ? 16  CYS A N   1 
ATOM   113  C  CA  . CYS A 1 16  ? 6.98307  -15.61924 6.73950   1.000 21.88703 ? 16  CYS A CA  1 
ATOM   114  C  C   . CYS A 1 16  ? 6.82077  -15.03355 8.13370   1.000 22.72875 ? 16  CYS A C   1 
ATOM   115  O  O   . CYS A 1 16  ? 7.72872  -15.18294 8.95793   1.000 21.95143 ? 16  CYS A O   1 
ATOM   116  C  CB  . CYS A 1 16  ? 8.17691  -14.93699 6.05398   1.000 22.44882 ? 16  CYS A CB  1 
ATOM   117  S  SG  . CYS A 1 16  ? 8.56299  -15.55548 4.39992   1.000 27.99865 ? 16  CYS A SG  1 
ATOM   118  N  N   . MET A 1 17  ? 5.70495  -14.37286 8.42106   1.000 23.10093 ? 17  MET A N   1 
ATOM   119  C  CA  . MET A 1 17  ? 5.56380  -13.65537 9.67929   1.000 21.58019 ? 17  MET A CA  1 
ATOM   120  C  C   . MET A 1 17  ? 5.10826  -14.60379 10.77875  1.000 22.34937 ? 17  MET A C   1 
ATOM   121  O  O   . MET A 1 17  ? 4.16192  -15.37543 10.59581  1.000 24.87764 ? 17  MET A O   1 
ATOM   122  C  CB  . MET A 1 17  ? 4.57612  -12.49869 9.52871   1.000 22.35662 ? 17  MET A CB  1 
ATOM   123  C  CG  . MET A 1 17  ? 5.00749  -11.43888 8.52524   1.000 22.52866 ? 17  MET A CG  1 
ATOM   124  S  SD  . MET A 1 17  ? 6.71172  -10.87720 8.75019   1.000 23.94201 ? 17  MET A SD  1 
ATOM   125  C  CE  . MET A 1 17  ? 6.66606  -10.25711 10.42792  1.000 25.09787 ? 17  MET A CE  1 
ATOM   126  N  N   . VAL A 1 18  ? 5.78869  -14.54623 11.92221  1.000 21.18769 ? 18  VAL A N   1 
ATOM   127  C  CA  . VAL A 1 18  ? 5.44775  -15.35829 13.07915  1.000 23.28067 ? 18  VAL A CA  1 
ATOM   128  C  C   . VAL A 1 18  ? 5.44710  -14.47482 14.31953  1.000 23.46279 ? 18  VAL A C   1 
ATOM   129  O  O   . VAL A 1 18  ? 5.91201  -13.33320 14.30616  1.000 22.38479 ? 18  VAL A O   1 
ATOM   130  C  CB  . VAL A 1 18  ? 6.40896  -16.55070 13.26786  1.000 22.66750 ? 18  VAL A CB  1 
ATOM   131  C  CG1 . VAL A 1 18  ? 6.38874  -17.44715 12.03763  1.000 23.05725 ? 18  VAL A CG1 1 
ATOM   132  C  CG2 . VAL A 1 18  ? 7.81579  -16.05754 13.56085  1.000 19.30331 ? 18  VAL A CG2 1 
ATOM   133  N  N   . GLN A 1 19  ? 4.90534  -15.02875 15.39748  1.000 23.78948 ? 19  GLN A N   1 
ATOM   134  C  CA  . GLN A 1 19  ? 4.87676  -14.38405 16.70111  1.000 24.30760 ? 19  GLN A CA  1 
ATOM   135  C  C   . GLN A 1 19  ? 5.98056  -14.97998 17.56351  1.000 23.95988 ? 19  GLN A C   1 
ATOM   136  O  O   . GLN A 1 19  ? 6.14540  -16.20253 17.60737  1.000 25.08209 ? 19  GLN A O   1 
ATOM   137  C  CB  . GLN A 1 19  ? 3.51181  -14.58040 17.36440  1.000 24.78028 ? 19  GLN A CB  1 
ATOM   138  C  CG  . GLN A 1 19  ? 3.38187  -13.98110 18.74970  1.000 31.91598 ? 19  GLN A CG  1 
ATOM   139  C  CD  . GLN A 1 19  ? 2.11017  -14.42198 19.45230  1.000 34.30369 ? 19  GLN A CD  1 
ATOM   140  O  OE1 . GLN A 1 19  ? 1.07139  -13.76828 19.35074  1.000 39.77191 ? 19  GLN A OE1 1 
ATOM   141  N  NE2 . GLN A 1 19  ? 2.18669  -15.53802 20.16804  1.000 31.14954 ? 19  GLN A NE2 1 
ATOM   142  N  N   . VAL A 1 20  ? 6.74498  -14.12098 18.22884  1.000 22.77307 ? 20  VAL A N   1 
ATOM   143  C  CA  . VAL A 1 20  ? 7.80589  -14.55159 19.12984  1.000 24.01894 ? 20  VAL A CA  1 
ATOM   144  C  C   . VAL A 1 20  ? 7.49142  -14.01817 20.51795  1.000 22.79594 ? 20  VAL A C   1 
ATOM   145  O  O   . VAL A 1 20  ? 7.27415  -12.81405 20.69047  1.000 25.97474 ? 20  VAL A O   1 
ATOM   146  C  CB  . VAL A 1 20  ? 9.19155  -14.07187 18.66220  1.000 22.67387 ? 20  VAL A CB  1 
ATOM   147  C  CG1 . VAL A 1 20  ? 10.26771 -14.55318 19.62953  1.000 22.89280 ? 20  VAL A CG1 1 
ATOM   148  C  CG2 . VAL A 1 20  ? 9.47776  -14.56609 17.24975  1.000 21.31394 ? 20  VAL A CG2 1 
ATOM   149  N  N   . THR A 1 21  ? 7.46504  -14.91136 21.50026  1.000 24.92516 ? 21  THR A N   1 
ATOM   150  C  CA  . THR A 1 21  ? 7.18756  -14.55418 22.88481  1.000 27.52227 ? 21  THR A CA  1 
ATOM   151  C  C   . THR A 1 21  ? 8.34255  -15.01373 23.76098  1.000 27.86297 ? 21  THR A C   1 
ATOM   152  O  O   . THR A 1 21  ? 8.77767  -16.16690 23.66767  1.000 28.70790 ? 21  THR A O   1 
ATOM   153  C  CB  . THR A 1 21  ? 5.87629  -15.17992 23.36764  1.000 24.25958 ? 21  THR A CB  1 
ATOM   154  O  OG1 . THR A 1 21  ? 4.79577  -14.70540 22.55811  1.000 27.34861 ? 21  THR A OG1 1 
ATOM   155  C  CG2 . THR A 1 21  ? 5.61373  -14.81222 24.81996  1.000 28.58359 ? 21  THR A CG2 1 
ATOM   156  N  N   . CYS A 1 22  ? 8.84107  -14.10723 24.59866  1.000 27.95413 ? 22  CYS A N   1 
ATOM   157  C  CA  . CYS A 1 22  ? 9.90550  -14.41261 25.54651  1.000 28.31612 ? 22  CYS A CA  1 
ATOM   158  C  C   . CYS A 1 22  ? 9.56013  -13.73348 26.86005  1.000 31.18339 ? 22  CYS A C   1 
ATOM   159  O  O   . CYS A 1 22  ? 9.46983  -12.50308 26.91965  1.000 31.27954 ? 22  CYS A O   1 
ATOM   160  C  CB  . CYS A 1 22  ? 11.26991 -13.94079 25.03282  1.000 26.49423 ? 22  CYS A CB  1 
ATOM   161  S  SG  . CYS A 1 22  ? 12.66713 -14.51497 26.02190  1.000 39.11808 ? 22  CYS A SG  1 
ATOM   162  N  N   . GLY A 1 23  ? 9.36333  -14.52459 27.90142  1.000 33.73209 ? 23  GLY A N   1 
ATOM   163  C  CA  . GLY A 1 23  ? 8.86577  -13.95556 29.13898  1.000 33.48635 ? 23  GLY A CA  1 
ATOM   164  C  C   . GLY A 1 23  ? 7.48011  -13.39554 28.90148  1.000 33.69902 ? 23  GLY A C   1 
ATOM   165  O  O   . GLY A 1 23  ? 6.56951  -14.09902 28.44708  1.000 34.57668 ? 23  GLY A O   1 
ATOM   166  N  N   . THR A 1 24  ? 7.30667  -12.10906 29.19048  1.000 33.75700 ? 24  THR A N   1 
ATOM   167  C  CA  . THR A 1 24  ? 6.03327  -11.43931 28.97375  1.000 34.74886 ? 24  THR A CA  1 
ATOM   168  C  C   . THR A 1 24  ? 5.98466  -10.65524 27.66943  1.000 36.81315 ? 24  THR A C   1 
ATOM   169  O  O   . THR A 1 24  ? 4.90154  -10.21696 27.26913  1.000 41.67175 ? 24  THR A O   1 
ATOM   170  C  CB  . THR A 1 24  ? 5.72617  -10.49802 30.14525  1.000 40.37526 ? 24  THR A CB  1 
ATOM   171  O  OG1 . THR A 1 24  ? 6.78015  -9.53445  30.27588  1.000 38.96765 ? 24  THR A OG1 1 
ATOM   172  C  CG2 . THR A 1 24  ? 5.60725  -11.28886 31.44146  1.000 41.90059 ? 24  THR A CG2 1 
ATOM   173  N  N   . THR A 1 25  ? 7.11635  -10.48386 26.99324  1.000 33.86672 ? 25  THR A N   1 
ATOM   174  C  CA  . THR A 1 25  ? 7.18425  -9.68661  25.77648  1.000 34.10011 ? 25  THR A CA  1 
ATOM   175  C  C   . THR A 1 25  ? 6.82567  -10.52801 24.55954  1.000 33.56826 ? 25  THR A C   1 
ATOM   176  O  O   . THR A 1 25  ? 7.26697  -11.67397 24.42717  1.000 31.82791 ? 25  THR A O   1 
ATOM   177  C  CB  . THR A 1 25  ? 8.58298  -9.09477  25.59718  1.000 34.27489 ? 25  THR A CB  1 
ATOM   178  O  OG1 . THR A 1 25  ? 8.91193  -8.29100  26.73668  1.000 34.55039 ? 25  THR A OG1 1 
ATOM   179  C  CG2 . THR A 1 25  ? 8.64344  -8.24098  24.33623  1.000 33.00212 ? 25  THR A CG2 1 
ATOM   180  N  N   . THR A 1 26  ? 6.02177  -9.94820  23.67140  1.000 29.65918 ? 26  THR A N   1 
ATOM   181  C  CA  . THR A 1 26  ? 5.63260  -10.59027 22.42413  1.000 30.65894 ? 26  THR A CA  1 
ATOM   182  C  C   . THR A 1 26  ? 5.78853  -9.59623  21.28495  1.000 28.55169 ? 26  THR A C   1 
ATOM   183  O  O   . THR A 1 26  ? 5.35854  -8.44436  21.39886  1.000 31.57436 ? 26  THR A O   1 
ATOM   184  C  CB  . THR A 1 26  ? 4.19092  -11.10211 22.48531  1.000 30.66770 ? 26  THR A CB  1 
ATOM   185  O  OG1 . THR A 1 26  ? 4.09990  -12.14597 23.46260  1.000 37.77615 ? 26  THR A OG1 1 
ATOM   186  C  CG2 . THR A 1 26  ? 3.75472  -11.63831 21.13186  1.000 29.00074 ? 26  THR A CG2 1 
ATOM   187  N  N   . LEU A 1 27  ? 6.40884  -10.03882 20.19721  1.000 25.99036 ? 27  LEU A N   1 
ATOM   188  C  CA  . LEU A 1 27  ? 6.55316  -9.21418  19.00567  1.000 23.65171 ? 27  LEU A CA  1 
ATOM   189  C  C   . LEU A 1 27  ? 6.62697  -10.13121 17.79215  1.000 22.32347 ? 27  LEU A C   1 
ATOM   190  O  O   . LEU A 1 27  ? 6.36364  -11.33457 17.88116  1.000 21.52449 ? 27  LEU A O   1 
ATOM   191  C  CB  . LEU A 1 27  ? 7.77335  -8.29119  19.12015  1.000 23.29149 ? 27  LEU A CB  1 
ATOM   192  C  CG  . LEU A 1 27  ? 9.07572  -8.84978  19.69271  1.000 24.25621 ? 27  LEU A CG  1 
ATOM   193  C  CD1 . LEU A 1 27  ? 9.64566  -9.96988  18.82253  1.000 23.67653 ? 27  LEU A CD1 1 
ATOM   194  C  CD2 . LEU A 1 27  ? 10.08302 -7.71817  19.85569  1.000 23.25510 ? 27  LEU A CD2 1 
ATOM   195  N  N   . ASN A 1 28  ? 6.98476  -9.55542  16.65157  1.000 22.24357 ? 28  ASN A N   1 
ATOM   196  C  CA  . ASN A 1 28  ? 6.96332  -10.26145 15.38326  1.000 21.50176 ? 28  ASN A CA  1 
ATOM   197  C  C   . ASN A 1 28  ? 8.34793  -10.78269 15.02914  1.000 20.23273 ? 28  ASN A C   1 
ATOM   198  O  O   . ASN A 1 28  ? 9.36691  -10.17818 15.36827  1.000 19.68442 ? 28  ASN A O   1 
ATOM   199  C  CB  . ASN A 1 28  ? 6.45158  -9.34501  14.27346  1.000 21.25028 ? 28  ASN A CB  1 
ATOM   200  C  CG  . ASN A 1 28  ? 5.12301  -8.70613  14.62140  1.000 21.90054 ? 28  ASN A CG  1 
ATOM   201  O  OD1 . ASN A 1 28  ? 4.08493  -9.36316  14.59344  1.000 21.01799 ? 28  ASN A OD1 1 
ATOM   202  N  ND2 . ASN A 1 28  ? 5.15042  -7.42107  14.96149  1.000 22.03943 ? 28  ASN A ND2 1 
ATOM   203  N  N   . GLY A 1 29  ? 8.36925  -11.92687 14.34124  1.000 21.37187 ? 29  GLY A N   1 
ATOM   204  C  CA  . GLY A 1 29  ? 9.59542  -12.47657 13.81231  1.000 18.92596 ? 29  GLY A CA  1 
ATOM   205  C  C   . GLY A 1 29  ? 9.41906  -12.87268 12.35671  1.000 19.59851 ? 29  GLY A C   1 
ATOM   206  O  O   . GLY A 1 29  ? 8.29885  -12.97169 11.84810  1.000 21.40473 ? 29  GLY A O   1 
ATOM   207  N  N   . LEU A 1 30  ? 10.54990 -13.09833 11.69436  1.000 21.39129 ? 30  LEU A N   1 
ATOM   208  C  CA  . LEU A 1 30  ? 10.58522 -13.45931 10.28036  1.000 21.39527 ? 30  LEU A CA  1 
ATOM   209  C  C   . LEU A 1 30  ? 11.14822 -14.86920 10.14757  1.000 21.08017 ? 30  LEU A C   1 
ATOM   210  O  O   . LEU A 1 30  ? 12.30408 -15.11395 10.50841  1.000 21.22055 ? 30  LEU A O   1 
ATOM   211  C  CB  . LEU A 1 30  ? 11.42889 -12.46064 9.48720   1.000 20.87658 ? 30  LEU A CB  1 
ATOM   212  C  CG  . LEU A 1 30  ? 11.47976 -12.61085 7.96524   1.000 21.26210 ? 30  LEU A CG  1 
ATOM   213  C  CD1 . LEU A 1 30  ? 10.16575 -12.16503 7.33344   1.000 20.25130 ? 30  LEU A CD1 1 
ATOM   214  C  CD2 . LEU A 1 30  ? 12.65283 -11.83499 7.38129   1.000 21.61444 ? 30  LEU A CD2 1 
ATOM   215  N  N   . TRP A 1 31  ? 10.33583 -15.78505 9.62319   1.000 21.43097 ? 31  TRP A N   1 
ATOM   216  C  CA  . TRP A 1 31  ? 10.68378 -17.20057 9.53010   1.000 19.96035 ? 31  TRP A CA  1 
ATOM   217  C  C   . TRP A 1 31  ? 11.10211 -17.52297 8.09765   1.000 20.94081 ? 31  TRP A C   1 
ATOM   218  O  O   . TRP A 1 31  ? 10.25558 -17.61634 7.20348   1.000 23.23892 ? 31  TRP A O   1 
ATOM   219  C  CB  . TRP A 1 31  ? 9.50083  -18.06140 9.96815   1.000 21.11672 ? 31  TRP A CB  1 
ATOM   220  C  CG  . TRP A 1 31  ? 9.75829  -19.53608 9.95146   1.000 22.43392 ? 31  TRP A CG  1 
ATOM   221  C  CD1 . TRP A 1 31  ? 10.97038 -20.16294 9.99208   1.000 23.35101 ? 31  TRP A CD1 1 
ATOM   222  C  CD2 . TRP A 1 31  ? 8.77300  -20.57315 9.88417   1.000 26.51584 ? 31  TRP A CD2 1 
ATOM   223  N  NE1 . TRP A 1 31  ? 10.79936 -21.52821 9.95863   1.000 21.38562 ? 31  TRP A NE1 1 
ATOM   224  C  CE2 . TRP A 1 31  ? 9.45931  -21.80448 9.89465   1.000 23.13713 ? 31  TRP A CE2 1 
ATOM   225  C  CE3 . TRP A 1 31  ? 7.37622  -20.57991 9.82128   1.000 22.90786 ? 31  TRP A CE3 1 
ATOM   226  C  CZ2 . TRP A 1 31  ? 8.79658  -23.02670 9.84022   1.000 26.08262 ? 31  TRP A CZ2 1 
ATOM   227  C  CZ3 . TRP A 1 31  ? 6.72164  -21.79420 9.76999   1.000 24.58297 ? 31  TRP A CZ3 1 
ATOM   228  C  CH2 . TRP A 1 31  ? 7.43044  -23.00020 9.77896   1.000 26.41625 ? 31  TRP A CH2 1 
ATOM   229  N  N   . LEU A 1 32  ? 12.40458 -17.70868 7.88674   1.000 21.96261 ? 32  LEU A N   1 
ATOM   230  C  CA  . LEU A 1 32  ? 12.95397 -18.03953 6.57862   1.000 26.78124 ? 32  LEU A CA  1 
ATOM   231  C  C   . LEU A 1 32  ? 13.81426 -19.28441 6.71536   1.000 26.99694 ? 32  LEU A C   1 
ATOM   232  O  O   . LEU A 1 32  ? 14.70436 -19.33579 7.57123   1.000 27.62601 ? 32  LEU A O   1 
ATOM   233  C  CB  . LEU A 1 32  ? 13.78149 -16.88279 6.01030   1.000 24.40081 ? 32  LEU A CB  1 
ATOM   234  C  CG  . LEU A 1 32  ? 13.05876 -15.54713 5.83499   1.000 26.19385 ? 32  LEU A CG  1 
ATOM   235  C  CD1 . LEU A 1 32  ? 14.04663 -14.45495 5.47137   1.000 20.78031 ? 32  LEU A CD1 1 
ATOM   236  C  CD2 . LEU A 1 32  ? 11.97309 -15.66876 4.77763   1.000 24.70209 ? 32  LEU A CD2 1 
ATOM   237  N  N   . ASP A 1 33  ? 13.55679 -20.27881 5.87281   1.000 26.29303 ? 33  ASP A N   1 
ATOM   238  C  CA  . ASP A 1 33  ? 14.21306 -21.58181 6.00822   1.000 28.71482 ? 33  ASP A CA  1 
ATOM   239  C  C   . ASP A 1 33  ? 13.93978 -22.04789 7.43752   1.000 26.22921 ? 33  ASP A C   1 
ATOM   240  O  O   . ASP A 1 33  ? 12.77559 -22.02252 7.86632   1.000 25.20270 ? 33  ASP A O   1 
ATOM   241  C  CB  . ASP A 1 33  ? 15.68165 -21.46191 5.61750   1.000 28.04718 ? 33  ASP A CB  1 
ATOM   242  C  CG  . ASP A 1 33  ? 15.86741 -21.00425 4.18518   1.000 31.07966 ? 33  ASP A CG  1 
ATOM   243  O  OD1 . ASP A 1 33  ? 14.98909 -21.30451 3.34984   1.000 31.67536 ? 33  ASP A OD1 1 
ATOM   244  O  OD2 . ASP A 1 33  ? 16.88946 -20.34435 3.89291   1.000 33.41466 ? 33  ASP A OD2 1 
ATOM   245  N  N   . ASP A 1 34  ? 14.94779 -22.45583 8.20416   1.000 24.88402 ? 34  ASP A N   1 
ATOM   246  C  CA  . ASP A 1 34  ? 14.76384 -22.91792 9.57615   1.000 27.80998 ? 34  ASP A CA  1 
ATOM   247  C  C   . ASP A 1 34  ? 15.32199 -21.92187 10.59084  1.000 26.79197 ? 34  ASP A C   1 
ATOM   248  O  O   . ASP A 1 34  ? 15.86855 -22.30818 11.62649  1.000 26.99524 ? 34  ASP A O   1 
ATOM   249  C  CB  . ASP A 1 34  ? 15.40275 -24.29051 9.77508   1.000 29.52169 ? 34  ASP A CB  1 
ATOM   250  C  CG  . ASP A 1 34  ? 16.89309 -24.29131 9.48421   1.000 31.52395 ? 34  ASP A CG  1 
ATOM   251  O  OD1 . ASP A 1 34  ? 17.40161 -23.28640 8.94287   1.000 30.61483 ? 34  ASP A OD1 1 
ATOM   252  O  OD2 . ASP A 1 34  ? 17.55876 -25.29832 9.80390   1.000 32.69748 ? 34  ASP A OD2 1 
ATOM   253  N  N   . VAL A 1 35  ? 15.19511 -20.62653 10.30743  1.000 23.85220 ? 35  VAL A N   1 
ATOM   254  C  CA  . VAL A 1 35  ? 15.64078 -19.57775 11.21761  1.000 25.59442 ? 35  VAL A CA  1 
ATOM   255  C  C   . VAL A 1 35  ? 14.52747 -18.55252 11.37496  1.000 25.15471 ? 35  VAL A C   1 
ATOM   256  O  O   . VAL A 1 35  ? 13.85731 -18.19222 10.39942  1.000 23.42256 ? 35  VAL A O   1 
ATOM   257  C  CB  . VAL A 1 35  ? 16.93289 -18.89168 10.72509  1.000 23.36752 ? 35  VAL A CB  1 
ATOM   258  C  CG1 . VAL A 1 35  ? 17.39244 -17.84594 11.73206  1.000 22.25246 ? 35  VAL A CG1 1 
ATOM   259  C  CG2 . VAL A 1 35  ? 18.02570 -19.91703 10.48209  1.000 27.32152 ? 35  VAL A CG2 1 
ATOM   260  N  N   . VAL A 1 36  ? 14.33523 -18.08016 12.60449  1.000 21.72887 ? 36  VAL A N   1 
ATOM   261  C  CA  . VAL A 1 36  ? 13.40683 -16.99642 12.90662  1.000 23.47518 ? 36  VAL A CA  1 
ATOM   262  C  C   . VAL A 1 36  ? 14.21658 -15.79606 13.37646  1.000 23.88310 ? 36  VAL A C   1 
ATOM   263  O  O   . VAL A 1 36  ? 15.02278 -15.91126 14.30760  1.000 22.53513 ? 36  VAL A O   1 
ATOM   264  C  CB  . VAL A 1 36  ? 12.37109 -17.41208 13.96484  1.000 23.93093 ? 36  VAL A CB  1 
ATOM   265  C  CG1 . VAL A 1 36  ? 11.50420 -16.22463 14.34908  1.000 20.10706 ? 36  VAL A CG1 1 
ATOM   266  C  CG2 . VAL A 1 36  ? 11.50983 -18.55673 13.44313  1.000 21.75537 ? 36  VAL A CG2 1 
ATOM   267  N  N   . TYR A 1 37  ? 14.00751 -14.65046 12.72765  1.000 22.60919 ? 37  TYR A N   1 
ATOM   268  C  CA  . TYR A 1 37  ? 14.69624 -13.40734 13.04778  1.000 22.24830 ? 37  TYR A CA  1 
ATOM   269  C  C   . TYR A 1 37  ? 13.73790 -12.45532 13.75483  1.000 22.41777 ? 37  TYR A C   1 
ATOM   270  O  O   . TYR A 1 37  ? 12.58164 -12.31220 13.34517  1.000 22.84079 ? 37  TYR A O   1 
ATOM   271  C  CB  . TYR A 1 37  ? 15.24265 -12.73934 11.77893  1.000 23.10855 ? 37  TYR A CB  1 
ATOM   272  C  CG  . TYR A 1 37  ? 16.12019 -13.62841 10.92033  1.000 22.62821 ? 37  TYR A CG  1 
ATOM   273  C  CD1 . TYR A 1 37  ? 15.56323 -14.53014 10.02276  1.000 22.02852 ? 37  TYR A CD1 1 
ATOM   274  C  CD2 . TYR A 1 37  ? 17.50479 -13.55277 10.99726  1.000 21.62442 ? 37  TYR A CD2 1 
ATOM   275  C  CE1 . TYR A 1 37  ? 16.35933 -15.34076 9.23320   1.000 21.25702 ? 37  TYR A CE1 1 
ATOM   276  C  CE2 . TYR A 1 37  ? 18.31104 -14.36089 10.21109  1.000 24.86866 ? 37  TYR A CE2 1 
ATOM   277  C  CZ  . TYR A 1 37  ? 17.73194 -15.25153 9.33107   1.000 22.28698 ? 37  TYR A CZ  1 
ATOM   278  O  OH  . TYR A 1 37  ? 18.52791 -16.05758 8.54798   1.000 25.42356 ? 37  TYR A OH  1 
ATOM   279  N  N   . CYS A 1 38  ? 14.21386 -11.80404 14.81426  1.000 23.82560 ? 38  CYS A N   1 
ATOM   280  C  CA  . CYS A 1 38  ? 13.39709 -10.83622 15.53703  1.000 20.26276 ? 38  CYS A CA  1 
ATOM   281  C  C   . CYS A 1 38  ? 14.31698 -9.88527  16.28994  1.000 20.80726 ? 38  CYS A C   1 
ATOM   282  O  O   . CYS A 1 38  ? 15.51191 -10.16590 16.45047  1.000 22.31174 ? 38  CYS A O   1 
ATOM   283  C  CB  . CYS A 1 38  ? 12.41759 -11.52992 16.50147  1.000 22.12342 ? 38  CYS A CB  1 
ATOM   284  S  SG  . CYS A 1 38  ? 13.13787 -12.22106 18.00989  1.000 22.74518 ? 38  CYS A SG  1 
ATOM   285  N  N   . PRO A 1 39  ? 13.79613 -8.74539  16.74554  1.000 20.11810 ? 39  PRO A N   1 
ATOM   286  C  CA  . PRO A 1 39  ? 14.62671 -7.80772  17.51070  1.000 20.68937 ? 39  PRO A CA  1 
ATOM   287  C  C   . PRO A 1 39  ? 15.06427 -8.41845  18.83197  1.000 21.96747 ? 39  PRO A C   1 
ATOM   288  O  O   . PRO A 1 39  ? 14.28275 -9.07575  19.52503  1.000 18.04384 ? 39  PRO A O   1 
ATOM   289  C  CB  . PRO A 1 39  ? 13.69889 -6.60501  17.73081  1.000 21.47472 ? 39  PRO A CB  1 
ATOM   290  C  CG  . PRO A 1 39  ? 12.64187 -6.73172  16.64730  1.000 18.95927 ? 39  PRO A CG  1 
ATOM   291  C  CD  . PRO A 1 39  ? 12.45109 -8.20886  16.47808  1.000 19.83598 ? 39  PRO A CD  1 
ATOM   292  N  N   . ARG A 1 40  ? 16.32971 -8.18896  19.18429  1.000 20.62575 ? 40  ARG A N   1 
ATOM   293  C  CA  . ARG A 1 40  ? 16.86279 -8.81903  20.38488  1.000 18.96754 ? 40  ARG A CA  1 
ATOM   294  C  C   . ARG A 1 40  ? 16.23869 -8.26160  21.65730  1.000 21.18998 ? 40  ARG A C   1 
ATOM   295  O  O   . ARG A 1 40  ? 16.30251 -8.92296  22.69868  1.000 21.40039 ? 40  ARG A O   1 
ATOM   296  C  CB  . ARG A 1 40  ? 18.38612 -8.67704  20.44037  1.000 18.93477 ? 40  ARG A CB  1 
ATOM   297  C  CG  . ARG A 1 40  ? 18.88971 -7.25878  20.65146  1.000 18.78617 ? 40  ARG A CG  1 
ATOM   298  C  CD  . ARG A 1 40  ? 20.39960 -7.23673  20.84560  1.000 20.74937 ? 40  ARG A CD  1 
ATOM   299  N  NE  . ARG A 1 40  ? 20.90843 -5.87634  20.98670  1.000 18.94150 ? 40  ARG A NE  1 
ATOM   300  C  CZ  . ARG A 1 40  ? 22.17312 -5.57424  21.24625  1.000 22.45305 ? 40  ARG A CZ  1 
ATOM   301  N  NH1 . ARG A 1 40  ? 23.08573 -6.51518  21.42799  1.000 21.08683 ? 40  ARG A NH1 1 
ATOM   302  N  NH2 . ARG A 1 40  ? 22.53157 -4.29639  21.32589  1.000 22.90522 ? 40  ARG A NH2 1 
ATOM   303  N  N   . HIS A 1 41  ? 15.62300 -7.07687  21.60233  1.000 22.47870 ? 41  HIS A N   1 
ATOM   304  C  CA  . HIS A 1 41  ? 15.01734 -6.54721  22.81837  1.000 21.80365 ? 41  HIS A CA  1 
ATOM   305  C  C   . HIS A 1 41  ? 13.77161 -7.32121  23.23442  1.000 22.02110 ? 41  HIS A C   1 
ATOM   306  O  O   . HIS A 1 41  ? 13.16801 -6.98845  24.25981  1.000 23.01323 ? 41  HIS A O   1 
ATOM   307  C  CB  . HIS A 1 41  ? 14.71160 -5.04779  22.66879  1.000 24.54571 ? 41  HIS A CB  1 
ATOM   308  C  CG  . HIS A 1 41  ? 13.59965 -4.72662  21.71515  1.000 24.51619 ? 41  HIS A CG  1 
ATOM   309  N  ND1 . HIS A 1 41  ? 13.81471 -4.10097  20.50482  1.000 24.99496 ? 41  HIS A ND1 1 
ATOM   310  C  CD2 . HIS A 1 41  ? 12.26052 -4.90403  21.81237  1.000 24.90303 ? 41  HIS A CD2 1 
ATOM   311  C  CE1 . HIS A 1 41  ? 12.65855 -3.92322  19.89031  1.000 25.79266 ? 41  HIS A CE1 1 
ATOM   312  N  NE2 . HIS A 1 41  ? 11.69984 -4.40634  20.66028  1.000 30.07717 ? 41  HIS A NE2 1 
ATOM   313  N  N   . VAL A 1 42  ? 13.39199 -8.36325  22.49177  1.000 21.88435 ? 42  VAL A N   1 
ATOM   314  C  CA  . VAL A 1 42  ? 12.34355 -9.26216  22.94685  1.000 21.68257 ? 42  VAL A CA  1 
ATOM   315  C  C   . VAL A 1 42  ? 12.70321 -9.93031  24.26766  1.000 24.92253 ? 42  VAL A C   1 
ATOM   316  O  O   . VAL A 1 42  ? 11.82123 -10.46794 24.93909  1.000 24.01042 ? 42  VAL A O   1 
ATOM   317  C  CB  . VAL A 1 42  ? 12.04070 -10.32680 21.86721  1.000 23.64187 ? 42  VAL A CB  1 
ATOM   318  C  CG1 . VAL A 1 42  ? 13.19931 -11.31996 21.76000  1.000 21.75340 ? 42  VAL A CG1 1 
ATOM   319  C  CG2 . VAL A 1 42  ? 10.73576 -11.05209 22.16395  1.000 26.45509 ? 42  VAL A CG2 1 
ATOM   320  N  N   . ILE A 1 43  ? 13.98093 -9.92230  24.65179  1.000 23.18335 ? 43  ILE A N   1 
ATOM   321  C  CA  . ILE A 1 43  ? 14.41788 -10.55091 25.89275  1.000 25.70181 ? 43  ILE A CA  1 
ATOM   322  C  C   . ILE A 1 43  ? 14.46794 -9.55519  27.04673  1.000 28.88442 ? 43  ILE A C   1 
ATOM   323  O  O   . ILE A 1 43  ? 14.95046 -9.89378  28.13153  1.000 29.87085 ? 43  ILE A O   1 
ATOM   324  C  CB  . ILE A 1 43  ? 15.77997 -11.24752 25.72531  1.000 22.35710 ? 43  ILE A CB  1 
ATOM   325  C  CG1 . ILE A 1 43  ? 16.88774 -10.21692 25.53821  1.000 26.37432 ? 43  ILE A CG1 1 
ATOM   326  C  CG2 . ILE A 1 43  ? 15.75376 -12.26984 24.58979  1.000 26.23933 ? 43  ILE A CG2 1 
ATOM   327  C  CD1 . ILE A 1 43  ? 18.27733 -10.82645 25.41125  1.000 27.63580 ? 43  ILE A CD1 1 
ATOM   328  N  N   . CYS A 1 44  ? 13.97694 -8.33843  26.84522  1.000 30.34485 ? 44  CYS A N   1 
ATOM   329  C  CA  . CYS A 1 44  ? 14.07489 -7.30291  27.86423  1.000 32.70609 ? 44  CYS A CA  1 
ATOM   330  C  C   . CYS A 1 44  ? 12.78718 -7.19177  28.66687  1.000 37.34226 ? 44  CYS A C   1 
ATOM   331  O  O   . CYS A 1 44  ? 11.69898 -7.49872  28.17607  1.000 40.86260 ? 44  CYS A O   1 
ATOM   332  C  CB  . CYS A 1 44  ? 14.38433 -5.93762  27.24866  1.000 33.46028 ? 44  CYS A CB  1 
ATOM   333  S  SG  . CYS A 1 44  ? 16.04355 -5.75590  26.60743  1.000 33.54475 ? 44  CYS A SG  1 
ATOM   334  N  N   . THR A 1 45  ? 12.92505 -6.73759  29.91011  1.000 43.13943 ? 45  THR A N   1 
ATOM   335  C  CA  . THR A 1 45  ? 11.79910 -6.29969  30.72125  1.000 46.06168 ? 45  THR A CA  1 
ATOM   336  C  C   . THR A 1 45  ? 11.72951 -4.77481  30.70926  1.000 49.67807 ? 45  THR A C   1 
ATOM   337  O  O   . THR A 1 45  ? 12.61055 -4.08889  30.18421  1.000 48.48300 ? 45  THR A O   1 
ATOM   338  C  CB  . THR A 1 45  ? 11.91328 -6.82412  32.16039  1.000 51.20987 ? 45  THR A CB  1 
ATOM   339  O  OG1 . THR A 1 45  ? 12.97072 -6.13824  32.84344  1.000 52.03110 ? 45  THR A OG1 1 
ATOM   340  C  CG2 . THR A 1 45  ? 12.20730 -8.32465  32.15942  1.000 50.93174 ? 45  THR A CG2 1 
ATOM   341  N  N   . SER A 1 46  ? 10.66140 -4.24474  31.30683  1.000 54.13068 ? 46  SER A N   1 
ATOM   342  C  CA  . SER A 1 46  ? 10.48455 -2.79785  31.34500  1.000 52.29327 ? 46  SER A CA  1 
ATOM   343  C  C   . SER A 1 46  ? 11.68893 -2.11759  31.97979  1.000 50.62896 ? 46  SER A C   1 
ATOM   344  O  O   . SER A 1 46  ? 12.20716 -1.13030  31.44859  1.000 54.09287 ? 46  SER A O   1 
ATOM   345  C  CB  . SER A 1 46  ? 9.20324  -2.44578  32.09748  1.000 53.24163 ? 46  SER A CB  1 
ATOM   346  O  OG  . SER A 1 46  ? 9.21547  -2.98324  33.40757  1.000 61.41821 ? 46  SER A OG  1 
ATOM   347  N  N   . GLU A 1 47  ? 12.15311 -2.63611  33.11851  1.000 51.37123 ? 47  GLU A N   1 
ATOM   348  C  CA  . GLU A 1 47  ? 13.28671 -2.03830  33.81400  1.000 50.14714 ? 47  GLU A CA  1 
ATOM   349  C  C   . GLU A 1 47  ? 14.61072 -2.25400  33.09144  1.000 50.83607 ? 47  GLU A C   1 
ATOM   350  O  O   . GLU A 1 47  ? 15.60049 -1.60375  33.44479  1.000 55.79182 ? 47  GLU A O   1 
ATOM   351  C  CB  . GLU A 1 47  ? 13.37607 -2.59637  35.23518  1.000 53.80710 ? 47  GLU A CB  1 
ATOM   352  N  N   . ASP A 1 48  ? 14.65309 -3.13941  32.09348  1.000 52.74085 ? 48  ASP A N   1 
ATOM   353  C  CA  . ASP A 1 48  ? 15.89058 -3.43257  31.37912  1.000 50.35717 ? 48  ASP A CA  1 
ATOM   354  C  C   . ASP A 1 48  ? 16.20103 -2.42902  30.27616  1.000 44.10756 ? 48  ASP A C   1 
ATOM   355  O  O   . ASP A 1 48  ? 17.37303 -2.26899  29.91794  1.000 43.49609 ? 48  ASP A O   1 
ATOM   356  C  CB  . ASP A 1 48  ? 15.82731 -4.83518  30.76382  1.000 46.57363 ? 48  ASP A CB  1 
ATOM   357  C  CG  . ASP A 1 48  ? 16.06044 -5.93512  31.78069  1.000 50.90309 ? 48  ASP A CG  1 
ATOM   358  O  OD1 . ASP A 1 48  ? 16.91224 -5.75281  32.67770  1.000 53.25871 ? 48  ASP A OD1 1 
ATOM   359  O  OD2 . ASP A 1 48  ? 15.39317 -6.98577  31.67652  1.000 48.50446 ? 48  ASP A OD2 1 
ATOM   360  N  N   . MET A 1 49  ? 15.18755 -1.74768  29.73834  1.000 46.54075 ? 49  MET A N   1 
ATOM   361  C  CA  . MET A 1 49  ? 15.34177 -0.99124  28.49956  1.000 43.35460 ? 49  MET A CA  1 
ATOM   362  C  C   . MET A 1 49  ? 16.25259 0.22381   28.62520  1.000 39.42319 ? 49  MET A C   1 
ATOM   363  O  O   . MET A 1 49  ? 16.63182 0.79063   27.59483  1.000 39.70762 ? 49  MET A O   1 
ATOM   364  C  CB  . MET A 1 49  ? 13.97174 -0.53953  27.99165  1.000 43.32893 ? 49  MET A CB  1 
ATOM   365  C  CG  . MET A 1 49  ? 13.69835 -0.89665  26.53967  1.000 42.06368 ? 49  MET A CG  1 
ATOM   366  S  SD  . MET A 1 49  ? 13.56208 -2.67575  26.28361  1.000 53.52453 ? 49  MET A SD  1 
ATOM   367  C  CE  . MET A 1 49  ? 12.23153 -3.07601  27.41606  1.000 48.67396 ? 49  MET A CE  1 
ATOM   368  N  N   . PHE A 1 50  ? 16.61409 0.64506   29.83632  1.000 34.93822 ? 50  PHE A N   1 
ATOM   369  C  CA  . PHE A 1 50  ? 17.37785 1.88327   29.95606  1.000 39.24791 ? 50  PHE A CA  1 
ATOM   370  C  C   . PHE A 1 50  ? 18.86288 1.66277   29.69910  1.000 39.06690 ? 50  PHE A C   1 
ATOM   371  O  O   . PHE A 1 50  ? 19.51567 2.50276   29.07014  1.000 37.74386 ? 50  PHE A O   1 
ATOM   372  C  CB  . PHE A 1 50  ? 17.13821 2.51104   31.32622  1.000 41.35248 ? 50  PHE A CB  1 
ATOM   373  C  CG  . PHE A 1 50  ? 15.71795 2.93634   31.53652  1.000 44.38185 ? 50  PHE A CG  1 
ATOM   374  C  CD1 . PHE A 1 50  ? 15.25862 4.13327   31.01158  1.000 40.62862 ? 50  PHE A CD1 1 
ATOM   375  C  CD2 . PHE A 1 50  ? 14.83208 2.12676   32.22887  1.000 48.40261 ? 50  PHE A CD2 1 
ATOM   376  C  CE1 . PHE A 1 50  ? 13.94837 4.52370   31.18782  1.000 42.04084 ? 50  PHE A CE1 1 
ATOM   377  C  CE2 . PHE A 1 50  ? 13.51878 2.51211   32.41097  1.000 49.58961 ? 50  PHE A CE2 1 
ATOM   378  C  CZ  . PHE A 1 50  ? 13.07561 3.71294   31.89070  1.000 48.65402 ? 50  PHE A CZ  1 
ATOM   379  N  N   . ASN A 1 51  ? 19.41549 0.54678   30.17244  1.000 37.34844 ? 51  ASN A N   1 
ATOM   380  C  CA  . ASN A 1 51  ? 20.77434 0.13742   29.81460  1.000 40.83817 ? 51  ASN A CA  1 
ATOM   381  C  C   . ASN A 1 51  ? 20.87174 -1.37161  29.94259  1.000 36.50479 ? 51  ASN A C   1 
ATOM   382  O  O   . ASN A 1 51  ? 21.49062 -1.90230  30.87342  1.000 36.84687 ? 51  ASN A O   1 
ATOM   383  C  CB  . ASN A 1 51  ? 21.81276 0.83693   30.68861  1.000 43.58024 ? 51  ASN A CB  1 
ATOM   384  C  CG  . ASN A 1 51  ? 23.22151 0.68124   30.14485  1.000 45.96819 ? 51  ASN A CG  1 
ATOM   385  O  OD1 . ASN A 1 51  ? 23.41295 0.39798   28.95994  1.000 48.12810 ? 51  ASN A OD1 1 
ATOM   386  N  ND2 . ASN A 1 51  ? 24.21458 0.86580   31.00655  1.000 54.75655 ? 51  ASN A ND2 1 
ATOM   387  N  N   . PRO A 1 52  ? 20.26356 -2.10655  29.01656  1.000 36.00277 ? 52  PRO A N   1 
ATOM   388  C  CA  . PRO A 1 52  ? 20.28987 -3.56732  29.10097  1.000 30.72196 ? 52  PRO A CA  1 
ATOM   389  C  C   . PRO A 1 52  ? 21.64582 -4.11970  28.69826  1.000 33.65191 ? 52  PRO A C   1 
ATOM   390  O  O   . PRO A 1 52  ? 22.30236 -3.61147  27.78573  1.000 32.57798 ? 52  PRO A O   1 
ATOM   391  C  CB  . PRO A 1 52  ? 19.20300 -3.99406  28.10910  1.000 32.45170 ? 52  PRO A CB  1 
ATOM   392  C  CG  . PRO A 1 52  ? 19.21571 -2.90392  27.08349  1.000 35.13047 ? 52  PRO A CG  1 
ATOM   393  C  CD  . PRO A 1 52  ? 19.51586 -1.63182  27.83712  1.000 34.62940 ? 52  PRO A CD  1 
ATOM   394  N  N   . ASN A 1 53  ? 22.06521 -5.17001  29.39679  1.000 28.76573 ? 53  ASN A N   1 
ATOM   395  C  CA  . ASN A 1 53  ? 23.24812 -5.93971  29.01733  1.000 31.82916 ? 53  ASN A CA  1 
ATOM   396  C  C   . ASN A 1 53  ? 22.73524 -7.17004  28.27685  1.000 27.13641 ? 53  ASN A C   1 
ATOM   397  O  O   . ASN A 1 53  ? 22.40948 -8.19166  28.87995  1.000 25.67947 ? 53  ASN A O   1 
ATOM   398  C  CB  . ASN A 1 53  ? 24.08932 -6.30297  30.23528  1.000 28.04707 ? 53  ASN A CB  1 
ATOM   399  C  CG  . ASN A 1 53  ? 25.42557 -6.90914  29.85649  1.000 33.06496 ? 53  ASN A CG  1 
ATOM   400  O  OD1 . ASN A 1 53  ? 25.50018 -7.78434  28.99305  1.000 31.78873 ? 53  ASN A OD1 1 
ATOM   401  N  ND2 . ASN A 1 53  ? 26.49272 -6.43478  30.48962  1.000 34.05193 ? 53  ASN A ND2 1 
ATOM   402  N  N   . TYR A 1 54  ? 22.64850 -7.05795  26.94847  1.000 28.93531 ? 54  TYR A N   1 
ATOM   403  C  CA  . TYR A 1 54  ? 22.00130 -8.10505  26.16494  1.000 28.48885 ? 54  TYR A CA  1 
ATOM   404  C  C   . TYR A 1 54  ? 22.72318 -9.43851  26.28748  1.000 26.00825 ? 54  TYR A C   1 
ATOM   405  O  O   . TYR A 1 54  ? 22.08098 -10.49257 26.24009  1.000 25.52169 ? 54  TYR A O   1 
ATOM   406  C  CB  . TYR A 1 54  ? 21.89818 -7.68216  24.70116  1.000 23.04112 ? 54  TYR A CB  1 
ATOM   407  C  CG  . TYR A 1 54  ? 20.84615 -6.62297  24.46413  1.000 23.52318 ? 54  TYR A CG  1 
ATOM   408  C  CD1 . TYR A 1 54  ? 19.50777 -6.96696  24.32954  1.000 24.77382 ? 54  TYR A CD1 1 
ATOM   409  C  CD2 . TYR A 1 54  ? 21.18864 -5.27849  24.38470  1.000 25.33586 ? 54  TYR A CD2 1 
ATOM   410  C  CE1 . TYR A 1 54  ? 18.54035 -6.00488  24.11429  1.000 21.85418 ? 54  TYR A CE1 1 
ATOM   411  C  CE2 . TYR A 1 54  ? 20.22584 -4.30751  24.16930  1.000 24.92162 ? 54  TYR A CE2 1 
ATOM   412  C  CZ  . TYR A 1 54  ? 18.90325 -4.67953  24.03494  1.000 24.40030 ? 54  TYR A CZ  1 
ATOM   413  O  OH  . TYR A 1 54  ? 17.93729 -3.72227  23.82080  1.000 25.23993 ? 54  TYR A OH  1 
ATOM   414  N  N   . GLU A 1 55  ? 24.04759 -9.42240  26.44169  1.000 26.12786 ? 55  GLU A N   1 
ATOM   415  C  CA  . GLU A 1 55  ? 24.76636 -10.67463 26.65706  1.000 29.60099 ? 55  GLU A CA  1 
ATOM   416  C  C   . GLU A 1 55  ? 24.30186 -11.35131 27.94171  1.000 28.33300 ? 55  GLU A C   1 
ATOM   417  O  O   . GLU A 1 55  ? 23.95082 -12.53763 27.94112  1.000 26.98843 ? 55  GLU A O   1 
ATOM   418  C  CB  . GLU A 1 55  ? 26.27433 -10.42060 26.68770  1.000 29.08385 ? 55  GLU A CB  1 
ATOM   419  C  CG  . GLU A 1 55  ? 26.86437 -9.98317  25.35353  1.000 34.39253 ? 55  GLU A CG  1 
ATOM   420  C  CD  . GLU A 1 55  ? 26.82047 -11.07824 24.30200  1.000 44.84751 ? 55  GLU A CD  1 
ATOM   421  O  OE1 . GLU A 1 55  ? 26.19535 -12.13050 24.55815  1.000 44.58480 ? 55  GLU A OE1 1 
ATOM   422  O  OE2 . GLU A 1 55  ? 27.41435 -10.88858 23.21696  1.000 45.06355 ? 55  GLU A OE2 1 
ATOM   423  N  N   . ASP A 1 56  ? 24.28011 -10.60252 29.04947  1.000 28.73839 ? 56  ASP A N   1 
ATOM   424  C  CA  . ASP A 1 56  ? 23.80829 -11.15762 30.31613  1.000 28.43639 ? 56  ASP A CA  1 
ATOM   425  C  C   . ASP A 1 56  ? 22.34921 -11.58743 30.22652  1.000 28.10044 ? 56  ASP A C   1 
ATOM   426  O  O   . ASP A 1 56  ? 21.97182 -12.64401 30.74561  1.000 29.49895 ? 56  ASP A O   1 
ATOM   427  C  CB  . ASP A 1 56  ? 23.98490 -10.13716 31.44066  1.000 28.15877 ? 56  ASP A CB  1 
ATOM   428  C  CG  . ASP A 1 56  ? 25.43816 -9.90532  31.80116  1.000 32.35683 ? 56  ASP A CG  1 
ATOM   429  O  OD1 . ASP A 1 56  ? 26.30541 -10.65922 31.31024  1.000 31.44875 ? 56  ASP A OD1 1 
ATOM   430  O  OD2 . ASP A 1 56  ? 25.71071 -8.96125  32.57548  1.000 30.10405 ? 56  ASP A OD2 1 
ATOM   431  N  N   . LEU A 1 57  ? 21.50906 -10.77560 29.58325  1.000 26.68119 ? 57  LEU A N   1 
ATOM   432  C  CA  . LEU A 1 57  ? 20.09573 -11.12204 29.47766  1.000 28.70068 ? 57  LEU A CA  1 
ATOM   433  C  C   . LEU A 1 57  ? 19.89808 -12.39017 28.65888  1.000 28.24094 ? 57  LEU A C   1 
ATOM   434  O  O   . LEU A 1 57  ? 19.10891 -13.26371 29.03525  1.000 28.94270 ? 57  LEU A O   1 
ATOM   435  C  CB  . LEU A 1 57  ? 19.31255 -9.95810  28.86988  1.000 27.27601 ? 57  LEU A CB  1 
ATOM   436  C  CG  . LEU A 1 57  ? 19.23023 -8.69784  29.73588  1.000 32.38741 ? 57  LEU A CG  1 
ATOM   437  C  CD1 . LEU A 1 57  ? 18.46951 -7.58723  29.02437  1.000 32.32629 ? 57  LEU A CD1 1 
ATOM   438  C  CD2 . LEU A 1 57  ? 18.58293 -9.02064  31.07382  1.000 32.47175 ? 57  LEU A CD2 1 
ATOM   439  N  N   . LEU A 1 58  ? 20.60984 -12.51174 27.53572  1.000 27.68376 ? 58  LEU A N   1 
ATOM   440  C  CA  . LEU A 1 58  ? 20.46083 -13.69208 26.69186  1.000 29.09456 ? 58  LEU A CA  1 
ATOM   441  C  C   . LEU A 1 58  ? 20.97326 -14.94752 27.38539  1.000 28.97893 ? 58  LEU A C   1 
ATOM   442  O  O   . LEU A 1 58  ? 20.48750 -16.05077 27.10912  1.000 26.68321 ? 58  LEU A O   1 
ATOM   443  C  CB  . LEU A 1 58  ? 21.18953 -13.48020 25.36497  1.000 27.11761 ? 58  LEU A CB  1 
ATOM   444  C  CG  . LEU A 1 58  ? 21.04653 -14.60202 24.33803  1.000 26.62397 ? 58  LEU A CG  1 
ATOM   445  C  CD1 . LEU A 1 58  ? 19.57652 -14.84997 24.03541  1.000 28.50908 ? 58  LEU A CD1 1 
ATOM   446  C  CD2 . LEU A 1 58  ? 21.81108 -14.26553 23.06664  1.000 29.03766 ? 58  LEU A CD2 1 
ATOM   447  N  N   . ILE A 1 59  ? 21.94185 -14.80052 28.29068  1.000 28.51741 ? 59  ILE A N   1 
ATOM   448  C  CA  . ILE A 1 59  ? 22.49796 -15.96009 28.97837  1.000 27.57277 ? 59  ILE A CA  1 
ATOM   449  C  C   . ILE A 1 59  ? 21.46371 -16.60706 29.89084  1.000 31.51985 ? 59  ILE A C   1 
ATOM   450  O  O   . ILE A 1 59  ? 21.51332 -17.81896 30.13582  1.000 34.08691 ? 59  ILE A O   1 
ATOM   451  C  CB  . ILE A 1 59  ? 23.76118 -15.55143 29.75685  1.000 28.57358 ? 59  ILE A CB  1 
ATOM   452  C  CG1 . ILE A 1 59  ? 24.94919 -15.40311 28.80172  1.000 27.25395 ? 59  ILE A CG1 1 
ATOM   453  C  CG2 . ILE A 1 59  ? 24.05412 -16.55339 30.86231  1.000 30.94558 ? 59  ILE A CG2 1 
ATOM   454  C  CD1 . ILE A 1 59  ? 26.21086 -14.89633 29.46597  1.000 27.05745 ? 59  ILE A CD1 1 
ATOM   455  N  N   . ARG A 1 60  ? 20.51604 -15.82792 30.40601  1.000 31.21350 ? 60  ARG A N   1 
ATOM   456  C  CA  . ARG A 1 60  ? 19.51008 -16.35644 31.31635  1.000 31.79678 ? 60  ARG A CA  1 
ATOM   457  C  C   . ARG A 1 60  ? 18.36552 -17.06018 30.59619  1.000 31.31893 ? 60  ARG A C   1 
ATOM   458  O  O   . ARG A 1 60  ? 17.48706 -17.61640 31.26403  1.000 34.18847 ? 60  ARG A O   1 
ATOM   459  C  CB  . ARG A 1 60  ? 18.96767 -15.22599 32.19655  1.000 32.90869 ? 60  ARG A CB  1 
ATOM   460  C  CG  . ARG A 1 60  ? 20.05186 -14.25319 32.64767  1.000 36.26839 ? 60  ARG A CG  1 
ATOM   461  C  CD  . ARG A 1 60  ? 19.61185 -13.34833 33.79388  1.000 45.16845 ? 60  ARG A CD  1 
ATOM   462  N  NE  . ARG A 1 60  ? 18.53850 -12.43341 33.42236  1.000 45.37130 ? 60  ARG A NE  1 
ATOM   463  C  CZ  . ARG A 1 60  ? 18.26757 -11.30279 34.06175  1.000 51.41217 ? 60  ARG A CZ  1 
ATOM   464  N  NH1 . ARG A 1 60  ? 18.99968 -10.89529 35.08662  1.000 54.51936 ? 60  ARG A NH1 1 
ATOM   465  N  NH2 . ARG A 1 60  ? 17.24055 -10.55903 33.65943  1.000 51.36611 ? 60  ARG A NH2 1 
ATOM   466  N  N   . LYS A 1 61  ? 18.35474 -17.06140 29.26593  1.000 30.41182 ? 61  LYS A N   1 
ATOM   467  C  CA  . LYS A 1 61  ? 17.29863 -17.69836 28.49298  1.000 30.83402 ? 61  LYS A CA  1 
ATOM   468  C  C   . LYS A 1 61  ? 17.78870 -19.01628 27.90783  1.000 30.85350 ? 61  LYS A C   1 
ATOM   469  O  O   . LYS A 1 61  ? 18.97483 -19.18601 27.61654  1.000 30.36879 ? 61  LYS A O   1 
ATOM   470  C  CB  . LYS A 1 61  ? 16.81439 -16.79196 27.35744  1.000 29.58616 ? 61  LYS A CB  1 
ATOM   471  C  CG  . LYS A 1 61  ? 16.93075 -15.30799 27.63626  1.000 34.14619 ? 61  LYS A CG  1 
ATOM   472  C  CD  . LYS A 1 61  ? 16.15459 -14.89944 28.87342  1.000 33.33220 ? 61  LYS A CD  1 
ATOM   473  C  CE  . LYS A 1 61  ? 14.66225 -15.04903 28.67375  1.000 32.04114 ? 61  LYS A CE  1 
ATOM   474  N  NZ  . LYS A 1 61  ? 13.90968 -14.45252 29.81415  1.000 30.35674 ? 61  LYS A NZ  1 
ATOM   475  N  N   . SER A 1 62  ? 16.85689 -19.94650 27.73265  1.000 28.97053 ? 62  SER A N   1 
ATOM   476  C  CA  . SER A 1 62  ? 17.11809 -21.23146 27.10483  1.000 29.83585 ? 62  SER A CA  1 
ATOM   477  C  C   . SER A 1 62  ? 16.19864 -21.40498 25.90222  1.000 28.88029 ? 62  SER A C   1 
ATOM   478  O  O   . SER A 1 62  ? 15.22876 -20.66490 25.71993  1.000 29.04594 ? 62  SER A O   1 
ATOM   479  C  CB  . SER A 1 62  ? 16.92260 -22.38395 28.09913  1.000 28.41873 ? 62  SER A CB  1 
ATOM   480  O  OG  . SER A 1 62  ? 17.81530 -22.26903 29.19438  1.000 35.85639 ? 62  SER A OG  1 
ATOM   481  N  N   . ASN A 1 63  ? 16.51418 -22.40471 25.07551  1.000 30.88311 ? 63  ASN A N   1 
ATOM   482  C  CA  . ASN A 1 63  ? 15.72440 -22.65278 23.87195  1.000 29.08520 ? 63  ASN A CA  1 
ATOM   483  C  C   . ASN A 1 63  ? 14.23218 -22.68258 24.17883  1.000 28.64757 ? 63  ASN A C   1 
ATOM   484  O  O   . ASN A 1 63  ? 13.42650 -22.07891 23.46139  1.000 29.39242 ? 63  ASN A O   1 
ATOM   485  C  CB  . ASN A 1 63  ? 16.15787 -23.96470 23.21567  1.000 28.58453 ? 63  ASN A CB  1 
ATOM   486  C  CG  . ASN A 1 63  ? 17.45681 -23.83073 22.44969  1.000 33.09250 ? 63  ASN A CG  1 
ATOM   487  O  OD1 . ASN A 1 63  ? 17.95669 -22.72418 22.24190  1.000 29.35758 ? 63  ASN A OD1 1 
ATOM   488  N  ND2 . ASN A 1 63  ? 18.00284 -24.95969 22.00707  1.000 30.92941 ? 63  ASN A ND2 1 
ATOM   489  N  N   . HIS A 1 64  ? 13.84525 -23.37551 25.25252  1.000 27.84316 ? 64  HIS A N   1 
ATOM   490  C  CA  . HIS A 1 64  ? 12.42997 -23.54292 25.56107  1.000 29.05545 ? 64  HIS A CA  1 
ATOM   491  C  C   . HIS A 1 64  ? 11.77464 -22.26268 26.06199  1.000 28.16492 ? 64  HIS A C   1 
ATOM   492  O  O   . HIS A 1 64  ? 10.54365 -22.21708 26.15006  1.000 30.53333 ? 64  HIS A O   1 
ATOM   493  C  CB  . HIS A 1 64  ? 12.23941 -24.66847 26.58612  1.000 29.39232 ? 64  HIS A CB  1 
ATOM   494  C  CG  . HIS A 1 64  ? 12.88668 -24.40738 27.91215  1.000 28.72007 ? 64  HIS A CG  1 
ATOM   495  N  ND1 . HIS A 1 64  ? 12.25186 -23.72862 28.93102  1.000 31.64486 ? 64  HIS A ND1 1 
ATOM   496  C  CD2 . HIS A 1 64  ? 14.10634 -24.74824 28.39187  1.000 28.93648 ? 64  HIS A CD2 1 
ATOM   497  C  CE1 . HIS A 1 64  ? 13.05499 -23.65530 29.97742  1.000 26.66347 ? 64  HIS A CE1 1 
ATOM   498  N  NE2 . HIS A 1 64  ? 14.18697 -24.26551 29.67634  1.000 27.80565 ? 64  HIS A NE2 1 
ATOM   499  N  N   . ASN A 1 65  ? 12.55184 -21.22637 26.37822  1.000 27.57625 ? 65  ASN A N   1 
ATOM   500  C  CA  . ASN A 1 65  ? 11.97793 -19.94891 26.78387  1.000 28.32926 ? 65  ASN A CA  1 
ATOM   501  C  C   . ASN A 1 65  ? 11.49306 -19.10966 25.60653  1.000 25.89595 ? 65  ASN A C   1 
ATOM   502  O  O   . ASN A 1 65  ? 10.78508 -18.12094 25.82467  1.000 26.96047 ? 65  ASN A O   1 
ATOM   503  C  CB  . ASN A 1 65  ? 12.99438 -19.13589 27.58930  1.000 26.01358 ? 65  ASN A CB  1 
ATOM   504  C  CG  . ASN A 1 65  ? 13.42802 -19.83186 28.86747  1.000 29.44396 ? 65  ASN A CG  1 
ATOM   505  O  OD1 . ASN A 1 65  ? 14.62205 -19.95556 29.14098  1.000 31.46376 ? 65  ASN A OD1 1 
ATOM   506  N  ND2 . ASN A 1 65  ? 12.46087 -20.28133 29.66141  1.000 26.21495 ? 65  ASN A ND2 1 
ATOM   507  N  N   . PHE A 1 66  ? 11.86075 -19.46039 24.37686  1.000 26.88693 ? 66  PHE A N   1 
ATOM   508  C  CA  . PHE A 1 66  ? 11.44852 -18.71535 23.19083  1.000 27.00815 ? 66  PHE A CA  1 
ATOM   509  C  C   . PHE A 1 66  ? 10.25799 -19.42798 22.55544  1.000 26.21518 ? 66  PHE A C   1 
ATOM   510  O  O   . PHE A 1 66  ? 10.41128 -20.50208 21.96685  1.000 31.30920 ? 66  PHE A O   1 
ATOM   511  C  CB  . PHE A 1 66  ? 12.60114 -18.58340 22.19668  1.000 28.80516 ? 66  PHE A CB  1 
ATOM   512  C  CG  . PHE A 1 66  ? 13.73872 -17.73247 22.68926  1.000 27.75596 ? 66  PHE A CG  1 
ATOM   513  C  CD1 . PHE A 1 66  ? 13.66608 -16.35255 22.62556  1.000 28.35173 ? 66  PHE A CD1 1 
ATOM   514  C  CD2 . PHE A 1 66  ? 14.88657 -18.31394 23.20170  1.000 28.28478 ? 66  PHE A CD2 1 
ATOM   515  C  CE1 . PHE A 1 66  ? 14.71437 -15.56733 23.07356  1.000 30.33938 ? 66  PHE A CE1 1 
ATOM   516  C  CE2 . PHE A 1 66  ? 15.93835 -17.53519 23.65111  1.000 28.57041 ? 66  PHE A CE2 1 
ATOM   517  C  CZ  . PHE A 1 66  ? 15.85204 -16.16004 23.58476  1.000 28.71852 ? 66  PHE A CZ  1 
ATOM   518  N  N   . LEU A 1 67  ? 9.07602  -18.82765 22.66949  1.000 26.39823 ? 67  LEU A N   1 
ATOM   519  C  CA  . LEU A 1 67  ? 7.85314  -19.40266 22.11816  1.000 28.37697 ? 67  LEU A CA  1 
ATOM   520  C  C   . LEU A 1 67  ? 7.60757  -18.80122 20.73941  1.000 27.85216 ? 67  LEU A C   1 
ATOM   521  O  O   . LEU A 1 67  ? 7.28541  -17.61418 20.62173  1.000 28.77476 ? 67  LEU A O   1 
ATOM   522  C  CB  . LEU A 1 67  ? 6.67239  -19.14803 23.05103  1.000 29.09813 ? 67  LEU A CB  1 
ATOM   523  C  CG  . LEU A 1 67  ? 6.79860  -19.75923 24.44796  1.000 29.02978 ? 67  LEU A CG  1 
ATOM   524  C  CD1 . LEU A 1 67  ? 5.68460  -19.26789 25.35868  1.000 34.06688 ? 67  LEU A CD1 1 
ATOM   525  C  CD2 . LEU A 1 67  ? 6.79548  -21.27508 24.36473  1.000 30.02678 ? 67  LEU A CD2 1 
ATOM   526  N  N   . VAL A 1 68  ? 7.75566  -19.61964 19.70024  1.000 24.89059 ? 68  VAL A N   1 
ATOM   527  C  CA  . VAL A 1 68  ? 7.54931  -19.20334 18.31588  1.000 25.75850 ? 68  VAL A CA  1 
ATOM   528  C  C   . VAL A 1 68  ? 6.29213  -19.88926 17.79918  1.000 28.17712 ? 68  VAL A C   1 
ATOM   529  O  O   . VAL A 1 68  ? 6.19410  -21.12254 17.82064  1.000 29.05265 ? 68  VAL A O   1 
ATOM   530  C  CB  . VAL A 1 68  ? 8.76046  -19.53854 17.43286  1.000 25.98470 ? 68  VAL A CB  1 
ATOM   531  C  CG1 . VAL A 1 68  ? 8.52676  -19.05571 16.00962  1.000 29.33050 ? 68  VAL A CG1 1 
ATOM   532  C  CG2 . VAL A 1 68  ? 10.02579 -18.92527 18.01156  1.000 25.10434 ? 68  VAL A CG2 1 
ATOM   533  N  N   . GLN A 1 69  ? 5.33514  -19.09227 17.33009  1.000 26.29424 ? 69  GLN A N   1 
ATOM   534  C  CA  . GLN A 1 69  ? 4.05308  -19.59574 16.85356  1.000 31.71220 ? 69  GLN A CA  1 
ATOM   535  C  C   . GLN A 1 69  ? 3.81327  -19.06761 15.44823  1.000 32.35932 ? 69  GLN A C   1 
ATOM   536  O  O   . GLN A 1 69  ? 3.78596  -17.85062 15.23772  1.000 28.57183 ? 69  GLN A O   1 
ATOM   537  C  CB  . GLN A 1 69  ? 2.91875  -19.17782 17.79397  1.000 31.02734 ? 69  GLN A CB  1 
ATOM   538  C  CG  . GLN A 1 69  ? 1.56700  -19.77518 17.45725  1.000 36.05391 ? 69  GLN A CG  1 
ATOM   539  C  CD  . GLN A 1 69  ? 0.54860  -19.57375 18.56522  1.000 39.59658 ? 69  GLN A CD  1 
ATOM   540  O  OE1 . GLN A 1 69  ? 0.90329  -19.45222 19.73933  1.000 34.70408 ? 69  GLN A OE1 1 
ATOM   541  N  NE2 . GLN A 1 69  ? -0.72623 -19.53636 18.19540  1.000 42.45809 ? 69  GLN A NE2 1 
ATOM   542  N  N   . ALA A 1 70  ? 3.64769  -19.98049 14.49199  1.000 34.21488 ? 70  ALA A N   1 
ATOM   543  C  CA  . ALA A 1 70  ? 3.35980  -19.63723 13.10037  1.000 33.36690 ? 70  ALA A CA  1 
ATOM   544  C  C   . ALA A 1 70  ? 1.87273  -19.87640 12.86706  1.000 38.31095 ? 70  ALA A C   1 
ATOM   545  O  O   . ALA A 1 70  ? 1.44399  -21.00768 12.62533  1.000 35.67068 ? 70  ALA A O   1 
ATOM   546  C  CB  . ALA A 1 70  ? 4.21795  -20.46025 12.14577  1.000 32.05375 ? 70  ALA A CB  1 
ATOM   547  N  N   . GLY A 1 71  ? 1.08531  -18.80779 12.93656  1.000 39.01579 ? 71  GLY A N   1 
ATOM   548  C  CA  . GLY A 1 71  ? -0.35399 -18.95998 12.91233  1.000 37.15145 ? 71  GLY A CA  1 
ATOM   549  C  C   . GLY A 1 71  ? -0.81954 -19.71734 14.13706  1.000 42.32400 ? 71  GLY A C   1 
ATOM   550  O  O   . GLY A 1 71  ? -0.72303 -19.21069 15.25865  1.000 43.67039 ? 71  GLY A O   1 
ATOM   551  N  N   . ASN A 1 72  ? -1.31247 -20.93726 13.94313  1.000 43.63943 ? 72  ASN A N   1 
ATOM   552  C  CA  . ASN A 1 72  ? -1.68781 -21.80394 15.05089  1.000 45.47311 ? 72  ASN A CA  1 
ATOM   553  C  C   . ASN A 1 72  ? -0.66233 -22.89943 15.31368  1.000 45.44857 ? 72  ASN A C   1 
ATOM   554  O  O   . ASN A 1 72  ? -0.86737 -23.72049 16.21303  1.000 47.23104 ? 72  ASN A O   1 
ATOM   555  C  CB  . ASN A 1 72  ? -3.06107 -22.43231 14.78815  1.000 46.88051 ? 72  ASN A CB  1 
ATOM   556  N  N   . VAL A 1 73  ? 0.43368  -22.92534 14.56198  1.000 41.64822 ? 73  VAL A N   1 
ATOM   557  C  CA  . VAL A 1 73  ? 1.42548  -23.99118 14.63704  1.000 41.01264 ? 73  VAL A CA  1 
ATOM   558  C  C   . VAL A 1 73  ? 2.57035  -23.52910 15.52563  1.000 39.30869 ? 73  VAL A C   1 
ATOM   559  O  O   . VAL A 1 73  ? 3.19963  -22.49833 15.25729  1.000 35.38841 ? 73  VAL A O   1 
ATOM   560  C  CB  . VAL A 1 73  ? 1.93938  -24.37363 13.24070  1.000 41.34053 ? 73  VAL A CB  1 
ATOM   561  C  CG1 . VAL A 1 73  ? 2.94213  -25.51393 13.33763  1.000 40.72515 ? 73  VAL A CG1 1 
ATOM   562  C  CG2 . VAL A 1 73  ? 0.77755  -24.74165 12.33331  1.000 46.44127 ? 73  VAL A CG2 1 
ATOM   563  N  N   . GLN A 1 74  ? 2.84658  -24.29286 16.57795  1.000 39.99771 ? 74  GLN A N   1 
ATOM   564  C  CA  . GLN A 1 74  ? 3.99115  -24.01797 17.43172  1.000 33.51852 ? 74  GLN A CA  1 
ATOM   565  C  C   . GLN A 1 74  ? 5.25422  -24.59660 16.80462  1.000 33.56218 ? 74  GLN A C   1 
ATOM   566  O  O   . GLN A 1 74  ? 5.25355  -25.72230 16.29701  1.000 34.97433 ? 74  GLN A O   1 
ATOM   567  C  CB  . GLN A 1 74  ? 3.77196  -24.60979 18.82516  1.000 34.33151 ? 74  GLN A CB  1 
ATOM   568  C  CG  . GLN A 1 74  ? 4.60329  -23.95948 19.92246  1.000 33.94974 ? 74  GLN A CG  1 
ATOM   569  C  CD  . GLN A 1 74  ? 4.09478  -22.57860 20.30363  1.000 32.73077 ? 74  GLN A CD  1 
ATOM   570  O  OE1 . GLN A 1 74  ? 2.93659  -22.23986 20.05795  1.000 32.29003 ? 74  GLN A OE1 1 
ATOM   571  N  NE2 . GLN A 1 74  ? 4.96189  -21.77532 20.91114  1.000 33.23901 ? 74  GLN A NE2 1 
ATOM   572  N  N   . LEU A 1 75  ? 6.32998  -23.81536 16.82966  1.000 30.04906 ? 75  LEU A N   1 
ATOM   573  C  CA  . LEU A 1 75  ? 7.61564  -24.23435 16.28893  1.000 31.44034 ? 75  LEU A CA  1 
ATOM   574  C  C   . LEU A 1 75  ? 8.55918  -24.60428 17.42385  1.000 31.52414 ? 75  LEU A C   1 
ATOM   575  O  O   . LEU A 1 75  ? 8.60336  -23.92534 18.45296  1.000 30.61390 ? 75  LEU A O   1 
ATOM   576  C  CB  . LEU A 1 75  ? 8.24313  -23.12940 15.43628  1.000 30.57167 ? 75  LEU A CB  1 
ATOM   577  C  CG  . LEU A 1 75  ? 7.39902  -22.59003 14.27730  1.000 29.40946 ? 75  LEU A CG  1 
ATOM   578  C  CD1 . LEU A 1 75  ? 8.21662  -21.65870 13.39274  1.000 24.69537 ? 75  LEU A CD1 1 
ATOM   579  C  CD2 . LEU A 1 75  ? 6.81228  -23.72985 13.47017  1.000 29.68481 ? 75  LEU A CD2 1 
ATOM   580  N  N   . ARG A 1 76  ? 9.31827  -25.67757 17.22673  1.000 31.01430 ? 76  ARG A N   1 
ATOM   581  C  CA  . ARG A 1 76  ? 10.24524 -26.16865 18.23803  1.000 30.72790 ? 76  ARG A CA  1 
ATOM   582  C  C   . ARG A 1 76  ? 11.60356 -25.50731 18.03287  1.000 31.29044 ? 76  ARG A C   1 
ATOM   583  O  O   . ARG A 1 76  ? 12.22435 -25.66743 16.97551  1.000 29.12691 ? 76  ARG A O   1 
ATOM   584  C  CB  . ARG A 1 76  ? 10.35872 -27.69103 18.16594  1.000 30.80585 ? 76  ARG A CB  1 
ATOM   585  C  CG  . ARG A 1 76  ? 11.24921 -28.30676 19.23094  1.000 34.31868 ? 76  ARG A CG  1 
ATOM   586  C  CD  . ARG A 1 76  ? 11.28660 -29.82420 19.10639  1.000 33.11544 ? 76  ARG A CD  1 
ATOM   587  N  NE  . ARG A 1 76  ? 9.96536  -30.42222 19.26362  1.000 32.03966 ? 76  ARG A NE  1 
ATOM   588  C  CZ  . ARG A 1 76  ? 9.44006  -30.77824 20.42813  1.000 34.02646 ? 76  ARG A CZ  1 
ATOM   589  N  NH1 . ARG A 1 76  ? 10.09819 -30.60857 21.56368  1.000 27.64097 ? 76  ARG A NH1 1 
ATOM   590  N  NH2 . ARG A 1 76  ? 8.22323  -31.31479 20.45443  1.000 36.63083 ? 76  ARG A NH2 1 
ATOM   591  N  N   . VAL A 1 77  ? 12.05599 -24.76566 19.04056  1.000 30.76679 ? 77  VAL A N   1 
ATOM   592  C  CA  . VAL A 1 77  ? 13.30412 -24.01214 18.97058  1.000 29.18125 ? 77  VAL A CA  1 
ATOM   593  C  C   . VAL A 1 77  ? 14.45098 -24.91136 19.41592  1.000 30.36944 ? 77  VAL A C   1 
ATOM   594  O  O   . VAL A 1 77  ? 14.44976 -25.42230 20.54145  1.000 31.97293 ? 77  VAL A O   1 
ATOM   595  C  CB  . VAL A 1 77  ? 13.23366 -22.74440 19.83467  1.000 27.17476 ? 77  VAL A CB  1 
ATOM   596  C  CG1 . VAL A 1 77  ? 14.57711 -22.03205 19.84753  1.000 26.20993 ? 77  VAL A CG1 1 
ATOM   597  C  CG2 . VAL A 1 77  ? 12.13215 -21.82080 19.33035  1.000 26.10789 ? 77  VAL A CG2 1 
ATOM   598  N  N   . ILE A 1 78  ? 15.44197 -25.08583 18.54158  1.000 30.23375 ? 78  ILE A N   1 
ATOM   599  C  CA  . ILE A 1 78  ? 16.57565 -25.96714 18.79657  1.000 26.27343 ? 78  ILE A CA  1 
ATOM   600  C  C   . ILE A 1 78  ? 17.88190 -25.19785 18.91740  1.000 30.65278 ? 78  ILE A C   1 
ATOM   601  O  O   . ILE A 1 78  ? 18.94279 -25.81011 19.05603  1.000 32.00417 ? 78  ILE A O   1 
ATOM   602  C  CB  . ILE A 1 78  ? 16.69218 -27.05606 17.71986  1.000 28.31684 ? 78  ILE A CB  1 
ATOM   603  C  CG1 . ILE A 1 78  ? 16.94906 -26.42129 16.34955  1.000 31.43914 ? 78  ILE A CG1 1 
ATOM   604  C  CG2 . ILE A 1 78  ? 15.42001 -27.88235 17.67859  1.000 26.92169 ? 78  ILE A CG2 1 
ATOM   605  C  CD1 . ILE A 1 78  ? 17.08934 -27.42775 15.22337  1.000 32.40361 ? 78  ILE A CD1 1 
ATOM   606  N  N   . GLY A 1 79  ? 17.83624 -23.87197 18.86677  1.000 26.46819 ? 79  GLY A N   1 
ATOM   607  C  CA  . GLY A 1 79  ? 19.04401 -23.07850 18.94683  1.000 28.82165 ? 79  GLY A CA  1 
ATOM   608  C  C   . GLY A 1 79  ? 18.75745 -21.59424 18.94038  1.000 25.51350 ? 79  GLY A C   1 
ATOM   609  O  O   . GLY A 1 79  ? 17.75635 -21.15745 18.36794  1.000 29.06216 ? 79  GLY A O   1 
ATOM   610  N  N   . HIS A 1 80  ? 19.62050 -20.80779 19.57560  1.000 27.84600 ? 80  HIS A N   1 
ATOM   611  C  CA  . HIS A 1 80  ? 19.43001 -19.36673 19.62179  1.000 25.52574 ? 80  HIS A CA  1 
ATOM   612  C  C   . HIS A 1 80  ? 20.78697 -18.68364 19.64998  1.000 27.96060 ? 80  HIS A C   1 
ATOM   613  O  O   . HIS A 1 80  ? 21.72882 -19.17346 20.28087  1.000 26.99592 ? 80  HIS A O   1 
ATOM   614  C  CB  . HIS A 1 80  ? 18.59312 -18.94274 20.83598  1.000 26.44760 ? 80  HIS A CB  1 
ATOM   615  C  CG  . HIS A 1 80  ? 19.26443 -19.18492 22.15254  1.000 29.89938 ? 80  HIS A CG  1 
ATOM   616  N  ND1 . HIS A 1 80  ? 18.96344 -20.26504 22.95471  1.000 31.91040 ? 80  HIS A ND1 1 
ATOM   617  C  CD2 . HIS A 1 80  ? 20.21508 -18.48052 22.81161  1.000 28.18109 ? 80  HIS A CD2 1 
ATOM   618  C  CE1 . HIS A 1 80  ? 19.70203 -20.21686 24.04941  1.000 31.28291 ? 80  HIS A CE1 1 
ATOM   619  N  NE2 . HIS A 1 80  ? 20.47179 -19.14525 23.98595  1.000 31.19747 ? 80  HIS A NE2 1 
ATOM   620  N  N   . SER A 1 81  ? 20.87568 -17.55208 18.95724  1.000 24.53395 ? 81  SER A N   1 
ATOM   621  C  CA  . SER A 1 81  ? 22.10482 -16.77970 18.89207  1.000 24.35765 ? 81  SER A CA  1 
ATOM   622  C  C   . SER A 1 81  ? 21.74599 -15.32181 18.66086  1.000 25.39065 ? 81  SER A C   1 
ATOM   623  O  O   . SER A 1 81  ? 20.62495 -14.99285 18.26380  1.000 23.83085 ? 81  SER A O   1 
ATOM   624  C  CB  . SER A 1 81  ? 23.02906 -17.28582 17.78087  1.000 21.03749 ? 81  SER A CB  1 
ATOM   625  O  OG  . SER A 1 81  ? 22.37866 -17.22413 16.52431  1.000 26.23769 ? 81  SER A OG  1 
ATOM   626  N  N   . MET A 1 82  ? 22.71468 -14.44951 18.90890  1.000 20.43917 ? 82  MET A N   1 
ATOM   627  C  CA  . MET A 1 82  ? 22.53757 -13.01530 18.75088  1.000 23.13055 ? 82  MET A CA  1 
ATOM   628  C  C   . MET A 1 82  ? 23.53761 -12.50516 17.72585  1.000 27.13567 ? 82  MET A C   1 
ATOM   629  O  O   . MET A 1 82  ? 24.73741 -12.77637 17.83764  1.000 26.83986 ? 82  MET A O   1 
ATOM   630  C  CB  . MET A 1 82  ? 22.71763 -12.29645 20.09055  1.000 24.90465 ? 82  MET A CB  1 
ATOM   631  C  CG  . MET A 1 82  ? 22.43391 -10.80808 20.05251  1.000 26.86255 ? 82  MET A CG  1 
ATOM   632  S  SD  . MET A 1 82  ? 22.32468 -10.11399 21.71429  1.000 27.88134 ? 82  MET A SD  1 
ATOM   633  C  CE  . MET A 1 82  ? 23.94604 -10.50760 22.36420  1.000 27.85021 ? 82  MET A CE  1 
ATOM   634  N  N   . GLN A 1 83  ? 23.04173 -11.78471 16.72159  1.000 23.59683 ? 83  GLN A N   1 
ATOM   635  C  CA  . GLN A 1 83  ? 23.88547 -11.13886 15.72000  1.000 24.02928 ? 83  GLN A CA  1 
ATOM   636  C  C   . GLN A 1 83  ? 23.56234 -9.65186  15.72112  1.000 23.88441 ? 83  GLN A C   1 
ATOM   637  O  O   . GLN A 1 83  ? 22.50622 -9.24142  15.22758  1.000 22.10339 ? 83  GLN A O   1 
ATOM   638  C  CB  . GLN A 1 83  ? 23.67595 -11.73964 14.33128  1.000 22.81998 ? 83  GLN A CB  1 
ATOM   639  C  CG  . GLN A 1 83  ? 24.45373 -11.00330 13.24777  1.000 21.70727 ? 83  GLN A CG  1 
ATOM   640  C  CD  . GLN A 1 83  ? 24.28943 -11.61300 11.86978  1.000 26.39511 ? 83  GLN A CD  1 
ATOM   641  O  OE1 . GLN A 1 83  ? 23.30559 -12.29869 11.58786  1.000 25.74508 ? 83  GLN A OE1 1 
ATOM   642  N  NE2 . GLN A 1 83  ? 25.25793 -11.36162 11.00033  1.000 30.98943 ? 83  GLN A NE2 1 
ATOM   643  N  N   . ASN A 1 84  ? 24.46731 -8.84761  16.26918  1.000 23.05055 ? 84  ASN A N   1 
ATOM   644  C  CA  . ASN A 1 84  ? 24.24474 -7.40593  16.39078  1.000 21.14243 ? 84  ASN A CA  1 
ATOM   645  C  C   . ASN A 1 84  ? 22.95795 -7.23179  17.19571  1.000 20.51743 ? 84  ASN A C   1 
ATOM   646  O  O   . ASN A 1 84  ? 22.83424 -7.82731  18.27810  1.000 18.57860 ? 84  ASN A O   1 
ATOM   647  C  CB  . ASN A 1 84  ? 24.25375 -6.78339  15.00205  1.000 21.16410 ? 84  ASN A CB  1 
ATOM   648  C  CG  . ASN A 1 84  ? 25.59891 -6.91861  14.31265  1.000 23.28124 ? 84  ASN A CG  1 
ATOM   649  O  OD1 . ASN A 1 84  ? 26.63818 -6.61562  14.89498  1.000 25.47714 ? 84  ASN A OD1 1 
ATOM   650  N  ND2 . ASN A 1 84  ? 25.58474 -7.38114  13.06762  1.000 21.91901 ? 84  ASN A ND2 1 
ATOM   651  N  N   . CYS A 1 85  ? 21.97601 -6.46796  16.71831  1.000 23.29149 ? 85  CYS A N   1 
ATOM   652  C  CA  . CYS A 1 85  ? 20.75042 -6.23309  17.47168  1.000 21.50282 ? 85  CYS A CA  1 
ATOM   653  C  C   . CYS A 1 85  ? 19.62352 -7.17415  17.06428  1.000 22.62122 ? 85  CYS A C   1 
ATOM   654  O  O   . CYS A 1 85  ? 18.45130 -6.88680  17.33425  1.000 21.48848 ? 85  CYS A O   1 
ATOM   655  C  CB  . CYS A 1 85  ? 20.31190 -4.77798  17.31968  1.000 20.07032 ? 85  CYS A CB  1 
ATOM   656  S  SG  . CYS A 1 85  ? 21.58527 -3.60014  17.81713  1.000 20.80217 ? 85  CYS A SG  1 
ATOM   657  N  N   . VAL A 1 86  ? 19.95379 -8.29985  16.43974  1.000 21.62650 ? 86  VAL A N   1 
ATOM   658  C  CA  . VAL A 1 86  ? 18.96587 -9.26073  15.97337  1.000 20.00423 ? 86  VAL A CA  1 
ATOM   659  C  C   . VAL A 1 86  ? 19.17636 -10.58386 16.69533  1.000 23.77892 ? 86  VAL A C   1 
ATOM   660  O  O   . VAL A 1 86  ? 20.31381 -10.99484 16.95223  1.000 23.09932 ? 86  VAL A O   1 
ATOM   661  C  CB  . VAL A 1 86  ? 19.04277 -9.44216  14.44377  1.000 23.00213 ? 86  VAL A CB  1 
ATOM   662  C  CG1 . VAL A 1 86  ? 18.79857 -10.88873 14.06433  1.000 27.87661 ? 86  VAL A CG1 1 
ATOM   663  C  CG2 . VAL A 1 86  ? 18.03363 -8.52645  13.76198  1.000 21.71970 ? 86  VAL A CG2 1 
ATOM   664  N  N   . LEU A 1 87  ? 18.07201 -11.23873 17.03281  1.000 21.55979 ? 87  LEU A N   1 
ATOM   665  C  CA  . LEU A 1 87  ? 18.08298 -12.56470 17.63298  1.000 21.44134 ? 87  LEU A CA  1 
ATOM   666  C  C   . LEU A 1 87  ? 17.71686 -13.58959 16.56606  1.000 24.05865 ? 87  LEU A C   1 
ATOM   667  O  O   . LEU A 1 87  ? 16.75467 -13.39169 15.81690  1.000 23.83755 ? 87  LEU A O   1 
ATOM   668  C  CB  . LEU A 1 87  ? 17.09968 -12.62173 18.80297  1.000 26.87776 ? 87  LEU A CB  1 
ATOM   669  C  CG  . LEU A 1 87  ? 17.08137 -13.83733 19.72296  1.000 30.48899 ? 87  LEU A CG  1 
ATOM   670  C  CD1 . LEU A 1 87  ? 18.41860 -13.99473 20.42885  1.000 29.68510 ? 87  LEU A CD1 1 
ATOM   671  C  CD2 . LEU A 1 87  ? 15.95298 -13.68520 20.72696  1.000 30.89413 ? 87  LEU A CD2 1 
ATOM   672  N  N   . LYS A 1 88  ? 18.49123 -14.67014 16.48426  1.000 21.29758 ? 88  LYS A N   1 
ATOM   673  C  CA  . LYS A 1 88  ? 18.28676 -15.71201 15.48436  1.000 25.60850 ? 88  LYS A CA  1 
ATOM   674  C  C   . LYS A 1 88  ? 17.93899 -17.01668 16.19088  1.000 26.13454 ? 88  LYS A C   1 
ATOM   675  O  O   . LYS A 1 88  ? 18.77267 -17.57781 16.91208  1.000 24.30718 ? 88  LYS A O   1 
ATOM   676  C  CB  . LYS A 1 88  ? 19.53030 -15.88205 14.60415  1.000 27.20565 ? 88  LYS A CB  1 
ATOM   677  C  CG  . LYS A 1 88  ? 20.04212 -14.58060 13.98610  1.000 28.57755 ? 88  LYS A CG  1 
ATOM   678  C  CD  . LYS A 1 88  ? 20.64321 -14.80940 12.60240  1.000 30.27680 ? 88  LYS A CD  1 
ATOM   679  C  CE  . LYS A 1 88  ? 21.92912 -15.62359 12.65544  1.000 32.38575 ? 88  LYS A CE  1 
ATOM   680  N  NZ  . LYS A 1 88  ? 23.08634 -14.83063 13.16242  1.000 33.28299 ? 88  LYS A NZ  1 
ATOM   681  N  N   . LEU A 1 89  ? 16.71889 -17.50537 15.96963  1.000 23.06678 ? 89  LEU A N   1 
ATOM   682  C  CA  . LEU A 1 89  ? 16.22071 -18.72002 16.60761  1.000 24.80175 ? 89  LEU A CA  1 
ATOM   683  C  C   . LEU A 1 89  ? 16.18626 -19.84927 15.58736  1.000 27.11467 ? 89  LEU A C   1 
ATOM   684  O  O   . LEU A 1 89  ? 15.43198 -19.78488 14.60802  1.000 24.87086 ? 89  LEU A O   1 
ATOM   685  C  CB  . LEU A 1 89  ? 14.83016 -18.49460 17.20079  1.000 23.20454 ? 89  LEU A CB  1 
ATOM   686  C  CG  . LEU A 1 89  ? 14.71087 -17.33384 18.19157  1.000 23.20313 ? 89  LEU A CG  1 
ATOM   687  C  CD1 . LEU A 1 89  ? 13.25985 -17.13048 18.58751  1.000 22.77730 ? 89  LEU A CD1 1 
ATOM   688  C  CD2 . LEU A 1 89  ? 15.57655 -17.59046 19.41332  1.000 25.00086 ? 89  LEU A CD2 1 
ATOM   689  N  N   . LYS A 1 90  ? 16.99577 -20.87920 15.82009  1.000 26.41914 ? 90  LYS A N   1 
ATOM   690  C  CA  . LYS A 1 90  ? 16.97972 -22.06131 14.97124  1.000 26.99528 ? 90  LYS A CA  1 
ATOM   691  C  C   . LYS A 1 90  ? 15.80544 -22.95331 15.36057  1.000 26.93290 ? 90  LYS A C   1 
ATOM   692  O  O   . LYS A 1 90  ? 15.64356 -23.30668 16.53391  1.000 27.76631 ? 90  LYS A O   1 
ATOM   693  C  CB  . LYS A 1 90  ? 18.30055 -22.82245 15.09621  1.000 27.28817 ? 90  LYS A CB  1 
ATOM   694  C  CG  . LYS A 1 90  ? 18.45786 -23.98075 14.11564  1.000 31.75053 ? 90  LYS A CG  1 
ATOM   695  C  CD  . LYS A 1 90  ? 18.82899 -23.49979 12.71767  1.000 32.76624 ? 90  LYS A CD  1 
ATOM   696  C  CE  . LYS A 1 90  ? 20.24262 -22.93485 12.67440  1.000 38.64533 ? 90  LYS A CE  1 
ATOM   697  N  NZ  . LYS A 1 90  ? 20.65888 -22.57056 11.28598  1.000 40.17753 ? 90  LYS A NZ  1 
ATOM   698  N  N   . VAL A 1 91  ? 14.97721 -23.30329 14.37858  1.000 26.71253 ? 91  VAL A N   1 
ATOM   699  C  CA  . VAL A 1 91  ? 13.82725 -24.16899 14.59714  1.000 29.29523 ? 91  VAL A CA  1 
ATOM   700  C  C   . VAL A 1 91  ? 14.02305 -25.44601 13.78991  1.000 28.69232 ? 91  VAL A C   1 
ATOM   701  O  O   . VAL A 1 91  ? 14.76777 -25.48192 12.80806  1.000 27.77137 ? 91  VAL A O   1 
ATOM   702  C  CB  . VAL A 1 91  ? 12.49723 -23.47765 14.22697  1.000 29.37436 ? 91  VAL A CB  1 
ATOM   703  C  CG1 . VAL A 1 91  ? 12.28789 -22.24378 15.09278  1.000 25.46156 ? 91  VAL A CG1 1 
ATOM   704  C  CG2 . VAL A 1 91  ? 12.47655 -23.10535 12.75026  1.000 26.91188 ? 91  VAL A CG2 1 
ATOM   705  N  N   . ASP A 1 92  ? 13.34342 -26.50874 14.22056  1.000 29.93298 ? 92  ASP A N   1 
ATOM   706  C  CA  . ASP A 1 92  ? 13.53228 -27.82473 13.61880  1.000 31.89311 ? 92  ASP A CA  1 
ATOM   707  C  C   . ASP A 1 92  ? 12.73724 -28.02019 12.33202  1.000 31.49557 ? 92  ASP A C   1 
ATOM   708  O  O   . ASP A 1 92  ? 12.72550 -29.13174 11.79209  1.000 33.36491 ? 92  ASP A O   1 
ATOM   709  C  CB  . ASP A 1 92  ? 13.16656 -28.92348 14.62277  1.000 33.08111 ? 92  ASP A CB  1 
ATOM   710  C  CG  . ASP A 1 92  ? 11.67864 -28.99448 14.89817  1.000 35.59470 ? 92  ASP A CG  1 
ATOM   711  O  OD1 . ASP A 1 92  ? 10.93728 -28.09867 14.43797  1.000 37.61496 ? 92  ASP A OD1 1 
ATOM   712  O  OD2 . ASP A 1 92  ? 11.24803 -29.95335 15.57535  1.000 38.79569 ? 92  ASP A OD2 1 
ATOM   713  N  N   . THR A 1 93  ? 12.07999 -26.98206 11.82439  1.000 31.75899 ? 93  THR A N   1 
ATOM   714  C  CA  A THR A 1 93  ? 11.26549 -27.09922 10.62325  0.500 31.08593 ? 93  THR A CA  1 
ATOM   715  C  CA  B THR A 1 93  ? 11.26215 -27.09703 10.62460  0.500 31.06488 ? 93  THR A CA  1 
ATOM   716  C  C   . THR A 1 93  ? 11.54510 -25.91618 9.70872   1.000 31.01681 ? 93  THR A C   1 
ATOM   717  O  O   . THR A 1 93  ? 11.60603 -24.77274 10.16937  1.000 29.60944 ? 93  THR A O   1 
ATOM   718  C  CB  A THR A 1 93  ? 9.77302  -27.15965 10.97083  0.500 30.50011 ? 93  THR A CB  1 
ATOM   719  C  CB  B THR A 1 93  ? 9.76914  -27.14598 10.97258  0.500 30.41550 ? 93  THR A CB  1 
ATOM   720  O  OG1 A THR A 1 93  ? 8.99823  -27.21138 9.76680   0.500 33.25393 ? 93  THR A OG1 1 
ATOM   721  O  OG1 B THR A 1 93  ? 9.51152  -28.26596 11.82850  0.500 29.94646 ? 93  THR A OG1 1 
ATOM   722  C  CG2 A THR A 1 93  ? 9.36707  -25.93872 11.77725  0.500 30.15832 ? 93  THR A CG2 1 
ATOM   723  C  CG2 B THR A 1 93  ? 8.92977  -27.27577 9.71073   0.500 33.28204 ? 93  THR A CG2 1 
ATOM   724  N  N   . ALA A 1 94  ? 11.72224 -26.19704 8.42107   1.000 26.66045 ? 94  ALA A N   1 
ATOM   725  C  CA  . ALA A 1 94  ? 11.90742 -25.14276 7.43596   1.000 27.30563 ? 94  ALA A CA  1 
ATOM   726  C  C   . ALA A 1 94  ? 10.55455 -24.56796 7.04011   1.000 29.46110 ? 94  ALA A C   1 
ATOM   727  O  O   . ALA A 1 94  ? 9.57988  -25.30383 6.86662   1.000 30.17029 ? 94  ALA A O   1 
ATOM   728  C  CB  . ALA A 1 94  ? 12.63008 -25.67965 6.20087   1.000 27.79850 ? 94  ALA A CB  1 
ATOM   729  N  N   . ASN A 1 95  ? 10.49109 -23.24607 6.90940   1.000 27.60288 ? 95  ASN A N   1 
ATOM   730  C  CA  . ASN A 1 95  ? 9.23148  -22.63143 6.51104   1.000 28.22899 ? 95  ASN A CA  1 
ATOM   731  C  C   . ASN A 1 95  ? 8.86182  -23.10710 5.11134   1.000 26.26825 ? 95  ASN A C   1 
ATOM   732  O  O   . ASN A 1 95  ? 9.57107  -22.80218 4.14446   1.000 26.82498 ? 95  ASN A O   1 
ATOM   733  C  CB  . ASN A 1 95  ? 9.32390  -21.10471 6.55698   1.000 24.15582 ? 95  ASN A CB  1 
ATOM   734  C  CG  . ASN A 1 95  ? 8.00702  -20.42975 6.20734   1.000 27.58924 ? 95  ASN A CG  1 
ATOM   735  O  OD1 . ASN A 1 95  ? 7.00828  -21.09425 5.92711   1.000 26.25849 ? 95  ASN A OD1 1 
ATOM   736  N  ND2 . ASN A 1 95  ? 7.99604  -19.10203 6.23873   1.000 27.00800 ? 95  ASN A ND2 1 
ATOM   737  N  N   . PRO A 1 96  ? 7.76788  -23.85654 4.96004   1.000 28.11312 ? 96  PRO A N   1 
ATOM   738  C  CA  . PRO A 1 96  ? 7.38237  -24.32189 3.61759   1.000 29.17294 ? 96  PRO A CA  1 
ATOM   739  C  C   . PRO A 1 96  ? 6.99239  -23.19612 2.67635   1.000 29.79090 ? 96  PRO A C   1 
ATOM   740  O  O   . PRO A 1 96  ? 6.92572  -23.41837 1.46013   1.000 30.30599 ? 96  PRO A O   1 
ATOM   741  C  CB  . PRO A 1 96  ? 6.19809  -25.25752 3.89857   1.000 27.84345 ? 96  PRO A CB  1 
ATOM   742  C  CG  . PRO A 1 96  ? 5.63645  -24.76989 5.19052   1.000 28.48550 ? 96  PRO A CG  1 
ATOM   743  C  CD  . PRO A 1 96  ? 6.81331  -24.28941 5.99444   1.000 27.04232 ? 96  PRO A CD  1 
ATOM   744  N  N   . LYS A 1 97  ? 6.73330  -21.99681 3.19386   1.000 29.41579 ? 97  LYS A N   1 
ATOM   745  C  CA  . LYS A 1 97  ? 6.37811  -20.84749 2.37441   1.000 25.75337 ? 97  LYS A CA  1 
ATOM   746  C  C   . LYS A 1 97  ? 7.55688  -19.91507 2.12725   1.000 26.70726 ? 97  LYS A C   1 
ATOM   747  O  O   . LYS A 1 97  ? 7.35348  -18.78962 1.66268   1.000 29.90427 ? 97  LYS A O   1 
ATOM   748  C  CB  . LYS A 1 97  ? 5.23274  -20.06803 3.02301   1.000 27.24480 ? 97  LYS A CB  1 
ATOM   749  C  CG  . LYS A 1 97  ? 3.93961  -20.85020 3.18660   1.000 33.97655 ? 97  LYS A CG  1 
ATOM   750  C  CD  . LYS A 1 97  ? 2.90292  -20.02813 3.93835   1.000 33.95690 ? 97  LYS A CD  1 
ATOM   751  C  CE  . LYS A 1 97  ? 1.65812  -20.84477 4.24849   1.000 40.40384 ? 97  LYS A CE  1 
ATOM   752  N  NZ  . LYS A 1 97  ? 0.72143  -20.10112 5.13879   1.000 40.72241 ? 97  LYS A NZ  1 
ATOM   753  N  N   . THR A 1 98  ? 8.77761  -20.35032 2.43080   1.000 29.47850 ? 98  THR A N   1 
ATOM   754  C  CA  . THR A 1 98  ? 9.95813  -19.51567 2.24245   1.000 27.52914 ? 98  THR A CA  1 
ATOM   755  C  C   . THR A 1 98  ? 10.11314 -19.14284 0.77443   1.000 30.49306 ? 98  THR A C   1 
ATOM   756  O  O   . THR A 1 98  ? 10.37429 -20.01483 -0.06606  1.000 30.26937 ? 98  THR A O   1 
ATOM   757  C  CB  . THR A 1 98  ? 11.22110 -20.22983 2.72978   1.000 29.49251 ? 98  THR A CB  1 
ATOM   758  O  OG1 . THR A 1 98  ? 11.07077 -20.59372 4.10725   1.000 27.80029 ? 98  THR A OG1 1 
ATOM   759  C  CG2 . THR A 1 98  ? 12.43422 -19.32538 2.58031   1.000 27.88506 ? 98  THR A CG2 1 
ATOM   760  N  N   . PRO A 1 99  ? 9.96190  -17.87122 0.42571   1.000 27.80383 ? 99  PRO A N   1 
ATOM   761  C  CA  . PRO A 1 99  ? 10.20509 -17.44396 -0.95280  1.000 30.49447 ? 99  PRO A CA  1 
ATOM   762  C  C   . PRO A 1 99  ? 11.69918 -17.35727 -1.22540  1.000 28.48317 ? 99  PRO A C   1 
ATOM   763  O  O   . PRO A 1 99  ? 12.53082 -17.49229 -0.32934  1.000 28.42533 ? 99  PRO A O   1 
ATOM   764  C  CB  . PRO A 1 99  ? 9.55324  -16.05995 -1.00660  1.000 28.32379 ? 99  PRO A CB  1 
ATOM   765  C  CG  . PRO A 1 99  ? 9.71358  -15.54027 0.38316   1.000 30.45829 ? 99  PRO A CG  1 
ATOM   766  C  CD  . PRO A 1 99  ? 9.58608  -16.74322 1.29611   1.000 28.64016 ? 99  PRO A CD  1 
ATOM   767  N  N   . LYS A 1 100 ? 12.03288 -17.13254 -2.49306  1.000 27.89835 ? 100 LYS A N   1 
ATOM   768  C  CA  . LYS A 1 100 ? 13.39315 -16.73027 -2.81769  1.000 28.72722 ? 100 LYS A CA  1 
ATOM   769  C  C   . LYS A 1 100 ? 13.65759 -15.37176 -2.18233  1.000 27.80633 ? 100 LYS A C   1 
ATOM   770  O  O   . LYS A 1 100 ? 12.80558 -14.47825 -2.22877  1.000 26.03308 ? 100 LYS A O   1 
ATOM   771  C  CB  . LYS A 1 100 ? 13.59811 -16.66776 -4.32979  1.000 28.75781 ? 100 LYS A CB  1 
ATOM   772  N  N   . TYR A 1 101 ? 14.82497 -15.21406 -1.56887  1.000 22.59328 ? 101 TYR A N   1 
ATOM   773  C  CA  . TYR A 1 101 ? 15.04505 -14.00422 -0.79396  1.000 24.60499 ? 101 TYR A CA  1 
ATOM   774  C  C   . TYR A 1 101 ? 16.53231 -13.74049 -0.64002  1.000 27.36057 ? 101 TYR A C   1 
ATOM   775  O  O   . TYR A 1 101 ? 17.36300 -14.65035 -0.72526  1.000 25.62450 ? 101 TYR A O   1 
ATOM   776  C  CB  . TYR A 1 101 ? 14.38633 -14.10302 0.58452   1.000 24.74866 ? 101 TYR A CB  1 
ATOM   777  C  CG  . TYR A 1 101 ? 15.14069 -14.98325 1.55352   1.000 25.17889 ? 101 TYR A CG  1 
ATOM   778  C  CD1 . TYR A 1 101 ? 14.98352 -16.36301 1.53686   1.000 27.35038 ? 101 TYR A CD1 1 
ATOM   779  C  CD2 . TYR A 1 101 ? 16.00583 -14.43277 2.49149   1.000 27.05071 ? 101 TYR A CD2 1 
ATOM   780  C  CE1 . TYR A 1 101 ? 15.66896 -17.17071 2.42641   1.000 27.23567 ? 101 TYR A CE1 1 
ATOM   781  C  CE2 . TYR A 1 101 ? 16.69661 -15.22959 3.38414   1.000 27.62239 ? 101 TYR A CE2 1 
ATOM   782  C  CZ  . TYR A 1 101 ? 16.52403 -16.60058 3.34746   1.000 30.64801 ? 101 TYR A CZ  1 
ATOM   783  O  OH  . TYR A 1 101 ? 17.20920 -17.39938 4.23571   1.000 29.49888 ? 101 TYR A OH  1 
ATOM   784  N  N   . LYS A 1 102 ? 16.84548 -12.46891 -0.40072  1.000 22.91002 ? 102 LYS A N   1 
ATOM   785  C  CA  . LYS A 1 102 ? 18.17571 -12.03238 -0.01683  1.000 24.05717 ? 102 LYS A CA  1 
ATOM   786  C  C   . LYS A 1 102 ? 18.03894 -11.00135 1.09480   1.000 24.37928 ? 102 LYS A C   1 
ATOM   787  O  O   . LYS A 1 102 ? 16.97838 -10.39851 1.28190   1.000 22.13597 ? 102 LYS A O   1 
ATOM   788  C  CB  . LYS A 1 102 ? 18.94723 -11.44052 -1.20687  1.000 25.06393 ? 102 LYS A CB  1 
ATOM   789  N  N   . PHE A 1 103 ? 19.11858 -10.82649 1.85121   1.000 20.75522 ? 103 PHE A N   1 
ATOM   790  C  CA  . PHE A 1 103 ? 19.25026 -9.72316  2.79238   1.000 24.57948 ? 103 PHE A CA  1 
ATOM   791  C  C   . PHE A 1 103 ? 20.09315 -8.64019  2.13826   1.000 25.82531 ? 103 PHE A C   1 
ATOM   792  O  O   . PHE A 1 103 ? 21.16996 -8.92763  1.60624   1.000 27.03915 ? 103 PHE A O   1 
ATOM   793  C  CB  . PHE A 1 103 ? 19.90739 -10.16737 4.10239   1.000 23.21317 ? 103 PHE A CB  1 
ATOM   794  C  CG  . PHE A 1 103 ? 19.05301 -11.06525 4.94688   1.000 23.22741 ? 103 PHE A CG  1 
ATOM   795  C  CD1 . PHE A 1 103 ? 17.70609 -11.23267 4.67401   1.000 21.38616 ? 103 PHE A CD1 1 
ATOM   796  C  CD2 . PHE A 1 103 ? 19.60254 -11.74042 6.02570   1.000 23.79397 ? 103 PHE A CD2 1 
ATOM   797  C  CE1 . PHE A 1 103 ? 16.92500 -12.06126 5.46122   1.000 22.04983 ? 103 PHE A CE1 1 
ATOM   798  C  CE2 . PHE A 1 103 ? 18.82582 -12.56466 6.81936   1.000 23.78018 ? 103 PHE A CE2 1 
ATOM   799  C  CZ  . PHE A 1 103 ? 17.48690 -12.72810 6.53543   1.000 25.32729 ? 103 PHE A CZ  1 
ATOM   800  N  N   . VAL A 1 104 ? 19.60380 -7.40102  2.16927   1.000 23.62116 ? 104 VAL A N   1 
ATOM   801  C  CA  . VAL A 1 104 ? 20.32656 -6.27703  1.59118   1.000 25.86665 ? 104 VAL A CA  1 
ATOM   802  C  C   . VAL A 1 104 ? 20.24264 -5.08777  2.53465   1.000 27.84329 ? 104 VAL A C   1 
ATOM   803  O  O   . VAL A 1 104 ? 19.31375 -4.95633  3.33443   1.000 27.73053 ? 104 VAL A O   1 
ATOM   804  C  CB  . VAL A 1 104 ? 19.79341 -5.87812  0.19704   1.000 27.80951 ? 104 VAL A CB  1 
ATOM   805  C  CG1 . VAL A 1 104 ? 19.74318 -7.08872  -0.72414  1.000 24.22453 ? 104 VAL A CG1 1 
ATOM   806  C  CG2 . VAL A 1 104 ? 18.43429 -5.21356  0.31809   1.000 29.05727 ? 104 VAL A CG2 1 
ATOM   807  N  N   . ARG A 1 105 ? 21.23773 -4.21821  2.43341   1.000 25.34031 ? 105 ARG A N   1 
ATOM   808  C  CA  . ARG A 1 105 ? 21.25990 -2.95613  3.15906   1.000 26.52953 ? 105 ARG A CA  1 
ATOM   809  C  C   . ARG A 1 105 ? 21.02885 -1.84544  2.14340   1.000 29.28743 ? 105 ARG A C   1 
ATOM   810  O  O   . ARG A 1 105 ? 21.87938 -1.59862  1.28222   1.000 28.47653 ? 105 ARG A O   1 
ATOM   811  C  CB  . ARG A 1 105 ? 22.58185 -2.76951  3.89824   1.000 24.67700 ? 105 ARG A CB  1 
ATOM   812  C  CG  . ARG A 1 105 ? 22.61051 -1.52768  4.78430   1.000 27.93242 ? 105 ARG A CG  1 
ATOM   813  C  CD  . ARG A 1 105 ? 23.81086 -1.51832  5.70431   1.000 27.14919 ? 105 ARG A CD  1 
ATOM   814  N  NE  . ARG A 1 105 ? 23.84519 -0.31619  6.52797   1.000 29.99245 ? 105 ARG A NE  1 
ATOM   815  C  CZ  . ARG A 1 105 ? 23.26826 -0.20649  7.71670   1.000 23.91935 ? 105 ARG A CZ  1 
ATOM   816  N  NH1 . ARG A 1 105 ? 22.59311 -1.21011  8.25273   1.000 22.01853 ? 105 ARG A NH1 1 
ATOM   817  N  NH2 . ARG A 1 105 ? 23.37019 0.93884   8.38292   1.000 23.21480 ? 105 ARG A NH2 1 
ATOM   818  N  N   . ILE A 1 106 ? 19.87685 -1.18775  2.23396   1.000 27.58021 ? 106 ILE A N   1 
ATOM   819  C  CA  . ILE A 1 106 ? 19.53813 -0.12643  1.29624   1.000 28.07466 ? 106 ILE A CA  1 
ATOM   820  C  C   . ILE A 1 106 ? 20.28323 1.15021   1.66897   1.000 26.14589 ? 106 ILE A C   1 
ATOM   821  O  O   . ILE A 1 106 ? 20.81265 1.28485   2.77902   1.000 26.91762 ? 106 ILE A O   1 
ATOM   822  C  CB  . ILE A 1 106 ? 18.01570 0.10163   1.24331   1.000 27.65717 ? 106 ILE A CB  1 
ATOM   823  C  CG1 . ILE A 1 106 ? 17.44295 0.25371   2.65179   1.000 27.31925 ? 106 ILE A CG1 1 
ATOM   824  C  CG2 . ILE A 1 106 ? 17.32821 -1.03922  0.49514   1.000 31.72777 ? 106 ILE A CG2 1 
ATOM   825  C  CD1 . ILE A 1 106 ? 17.76949 1.56783   3.30982   1.000 29.02577 ? 106 ILE A CD1 1 
ATOM   826  N  N   . GLN A 1 107 ? 20.33156 2.08305   0.74637   1.000 29.20426 ? 107 GLN A N   1 
ATOM   827  C  CA  . GLN A 1 107 ? 20.97004 3.36952   0.95038   1.000 28.92478 ? 107 GLN A CA  1 
ATOM   828  C  C   . GLN A 1 107 ? 19.93227 4.42349   1.28555   1.000 27.12179 ? 107 GLN A C   1 
ATOM   829  O  O   . GLN A 1 107 ? 18.74517 4.25809   0.98890   1.000 26.53042 ? 107 GLN A O   1 
ATOM   830  C  CB  . GLN A 1 107 ? 21.73686 3.78910   -0.30851  1.000 32.07945 ? 107 GLN A CB  1 
ATOM   831  C  CG  . GLN A 1 107 ? 22.84331 2.82839   -0.69747  1.000 32.61591 ? 107 GLN A CG  1 
ATOM   832  C  CD  . GLN A 1 107 ? 23.91717 2.74128   0.36465   1.000 40.69741 ? 107 GLN A CD  1 
ATOM   833  O  OE1 . GLN A 1 107 ? 24.56147 3.73790   0.69353   1.000 45.31322 ? 107 GLN A OE1 1 
ATOM   834  N  NE2 . GLN A 1 107 ? 24.10605 1.55046   0.92099   1.000 40.99119 ? 107 GLN A NE2 1 
ATOM   835  N  N   . PRO A 1 108 ? 20.34095 5.53002   1.90388   1.000 26.55853 ? 108 PRO A N   1 
ATOM   836  C  CA  . PRO A 1 108 ? 19.39786 6.63452   2.10645   1.000 25.55735 ? 108 PRO A CA  1 
ATOM   837  C  C   . PRO A 1 108 ? 18.84862 7.11088   0.77035   1.000 25.10308 ? 108 PRO A C   1 
ATOM   838  O  O   . PRO A 1 108 ? 19.54836 7.11777   -0.24491  1.000 25.41813 ? 108 PRO A O   1 
ATOM   839  C  CB  . PRO A 1 108 ? 20.24534 7.71270   2.79500   1.000 25.34542 ? 108 PRO A CB  1 
ATOM   840  C  CG  . PRO A 1 108 ? 21.66290 7.35269   2.48041   1.000 26.16115 ? 108 PRO A CG  1 
ATOM   841  C  CD  . PRO A 1 108 ? 21.69069 5.85499   2.39474   1.000 27.13238 ? 108 PRO A CD  1 
ATOM   842  N  N   . GLY A 1 109 ? 17.57595 7.49720   0.77546   1.000 25.42025 ? 109 GLY A N   1 
ATOM   843  C  CA  . GLY A 1 109 ? 16.89278 7.91445   -0.42462  1.000 24.75882 ? 109 GLY A CA  1 
ATOM   844  C  C   . GLY A 1 109 ? 16.12972 6.81716   -1.13418  1.000 26.39593 ? 109 GLY A C   1 
ATOM   845  O  O   . GLY A 1 109 ? 15.22872 7.12011   -1.92302  1.000 29.65532 ? 109 GLY A O   1 
ATOM   846  N  N   . GLN A 1 110 ? 16.45869 5.55598   -0.87664  1.000 27.96064 ? 110 GLN A N   1 
ATOM   847  C  CA  . GLN A 1 110 ? 15.77137 4.43529   -1.49866  1.000 29.75709 ? 110 GLN A CA  1 
ATOM   848  C  C   . GLN A 1 110 ? 14.49480 4.08821   -0.73479  1.000 28.63560 ? 110 GLN A C   1 
ATOM   849  O  O   . GLN A 1 110 ? 14.33777 4.39905   0.45064   1.000 24.95594 ? 110 GLN A O   1 
ATOM   850  C  CB  . GLN A 1 110 ? 16.68919 3.21346   -1.58103  1.000 28.27291 ? 110 GLN A CB  1 
ATOM   851  C  CG  . GLN A 1 110 ? 17.87372 3.40498   -2.51928  1.000 28.61188 ? 110 GLN A CG  1 
ATOM   852  C  CD  . GLN A 1 110 ? 18.66394 2.12715   -2.73973  1.000 37.89847 ? 110 GLN A CD  1 
ATOM   853  O  OE1 . GLN A 1 110 ? 19.26864 1.58561   -1.81320  1.000 32.64651 ? 110 GLN A OE1 1 
ATOM   854  N  NE2 . GLN A 1 110 ? 18.66016 1.63679   -3.97495  1.000 48.72955 ? 110 GLN A NE2 1 
ATOM   855  N  N   . THR A 1 111 ? 13.57877 3.42934   -1.43829  1.000 24.94727 ? 111 THR A N   1 
ATOM   856  C  CA  . THR A 1 111 ? 12.26095 3.10467   -0.91901  1.000 25.79447 ? 111 THR A CA  1 
ATOM   857  C  C   . THR A 1 111 ? 12.10705 1.60149   -0.72900  1.000 23.27412 ? 111 THR A C   1 
ATOM   858  O  O   . THR A 1 111 ? 12.88804 0.79794   -1.24764  1.000 24.18740 ? 111 THR A O   1 
ATOM   859  C  CB  . THR A 1 111 ? 11.16117 3.61848   -1.85383  1.000 20.96992 ? 111 THR A CB  1 
ATOM   860  O  OG1 . THR A 1 111 ? 11.33860 3.05379   -3.16059  1.000 25.15697 ? 111 THR A OG1 1 
ATOM   861  C  CG2 . THR A 1 111 ? 11.20901 5.13491   -1.94791  1.000 25.23689 ? 111 THR A CG2 1 
ATOM   862  N  N   . PHE A 1 112 ? 11.07629 1.23344   0.02735   1.000 24.45153 ? 112 PHE A N   1 
ATOM   863  C  CA  . PHE A 1 112 ? 10.73124 -0.16312  0.25697   1.000 21.79745 ? 112 PHE A CA  1 
ATOM   864  C  C   . PHE A 1 112 ? 9.32887  -0.22160  0.84268   1.000 24.60466 ? 112 PHE A C   1 
ATOM   865  O  O   . PHE A 1 112 ? 8.79318  0.78614   1.31560   1.000 22.90972 ? 112 PHE A O   1 
ATOM   866  C  CB  . PHE A 1 112 ? 11.73736 -0.85143  1.18814   1.000 23.82486 ? 112 PHE A CB  1 
ATOM   867  C  CG  . PHE A 1 112 ? 11.87616 -0.18922  2.53209   1.000 23.17818 ? 112 PHE A CG  1 
ATOM   868  C  CD1 . PHE A 1 112 ? 12.80997 0.81597   2.73082   1.000 24.93776 ? 112 PHE A CD1 1 
ATOM   869  C  CD2 . PHE A 1 112 ? 11.08333 -0.57959  3.59845   1.000 22.70122 ? 112 PHE A CD2 1 
ATOM   870  C  CE1 . PHE A 1 112 ? 12.94503 1.42285   3.96827   1.000 28.30996 ? 112 PHE A CE1 1 
ATOM   871  C  CE2 . PHE A 1 112 ? 11.21307 0.02334   4.84008   1.000 26.22008 ? 112 PHE A CE2 1 
ATOM   872  C  CZ  . PHE A 1 112 ? 12.14344 1.02760   5.02395   1.000 25.83860 ? 112 PHE A CZ  1 
ATOM   873  N  N   . SER A 1 113 ? 8.74279  -1.41612  0.80770   1.000 18.81708 ? 113 SER A N   1 
ATOM   874  C  CA  . SER A 1 113 ? 7.42468  -1.64092  1.38141   1.000 21.88997 ? 113 SER A CA  1 
ATOM   875  C  C   . SER A 1 113 ? 7.55040  -2.16183  2.80619   1.000 20.36935 ? 113 SER A C   1 
ATOM   876  O  O   . SER A 1 113 ? 8.43010  -2.97393  3.10850   1.000 20.45598 ? 113 SER A O   1 
ATOM   877  C  CB  . SER A 1 113 ? 6.62538  -2.63272  0.53537   1.000 22.48893 ? 113 SER A CB  1 
ATOM   878  O  OG  . SER A 1 113 ? 6.39452  -2.11972  -0.76057  1.000 25.11003 ? 113 SER A OG  1 
ATOM   879  N  N   . VAL A 1 114 ? 6.66651  -1.68286  3.67810   1.000 20.50278 ? 114 VAL A N   1 
ATOM   880  C  CA  . VAL A 1 114 ? 6.58392  -2.12999  5.06390   1.000 21.17211 ? 114 VAL A CA  1 
ATOM   881  C  C   . VAL A 1 114 ? 5.29779  -2.92240  5.23658   1.000 21.84050 ? 114 VAL A C   1 
ATOM   882  O  O   . VAL A 1 114 ? 4.21385  -2.44457  4.87939   1.000 23.24717 ? 114 VAL A O   1 
ATOM   883  C  CB  . VAL A 1 114 ? 6.62121  -0.94854  6.04941   1.000 21.55791 ? 114 VAL A CB  1 
ATOM   884  C  CG1 . VAL A 1 114 ? 6.33651  -1.43650  7.46542   1.000 23.44416 ? 114 VAL A CG1 1 
ATOM   885  C  CG2 . VAL A 1 114 ? 7.96092  -0.23380  5.98067   1.000 24.69900 ? 114 VAL A CG2 1 
ATOM   886  N  N   . LEU A 1 115 ? 5.41624  -4.12621  5.78570   1.000 23.35879 ? 115 LEU A N   1 
ATOM   887  C  CA  . LEU A 1 115 ? 4.26304  -4.92718  6.18741   1.000 22.73136 ? 115 LEU A CA  1 
ATOM   888  C  C   . LEU A 1 115 ? 4.14105  -4.80008  7.70165   1.000 24.36121 ? 115 LEU A C   1 
ATOM   889  O  O   . LEU A 1 115 ? 4.86256  -5.46350  8.45246   1.000 23.04265 ? 115 LEU A O   1 
ATOM   890  C  CB  . LEU A 1 115 ? 4.41813  -6.38110  5.75130   1.000 22.65689 ? 115 LEU A CB  1 
ATOM   891  C  CG  . LEU A 1 115 ? 3.27603  -7.32218  6.14642   1.000 24.33712 ? 115 LEU A CG  1 
ATOM   892  C  CD1 . LEU A 1 115 ? 1.96868  -6.88843  5.49600   1.000 25.51527 ? 115 LEU A CD1 1 
ATOM   893  C  CD2 . LEU A 1 115 ? 3.60171  -8.76590  5.78699   1.000 21.63745 ? 115 LEU A CD2 1 
ATOM   894  N  N   . ALA A 1 116 ? 3.24409  -3.92360  8.14748   1.000 20.63950 ? 116 ALA A N   1 
ATOM   895  C  CA  . ALA A 1 116 ? 3.01826  -3.74126  9.57382   1.000 24.00095 ? 116 ALA A CA  1 
ATOM   896  C  C   . ALA A 1 116 ? 2.31762  -4.96351  10.15074  1.000 24.24635 ? 116 ALA A C   1 
ATOM   897  O  O   . ALA A 1 116 ? 1.28311  -5.39833  9.63456   1.000 26.40634 ? 116 ALA A O   1 
ATOM   898  C  CB  . ALA A 1 116 ? 2.18731  -2.48387  9.82546   1.000 21.40596 ? 116 ALA A CB  1 
ATOM   899  N  N   . CYS A 1 117 ? 2.88333  -5.51608  11.22487  1.000 22.83194 ? 117 CYS A N   1 
ATOM   900  C  CA  . CYS A 1 117 ? 2.36834  -6.72373  11.85004  1.000 23.41912 ? 117 CYS A CA  1 
ATOM   901  C  C   . CYS A 1 117 ? 2.21235  -6.52429  13.35060  1.000 24.79310 ? 117 CYS A C   1 
ATOM   902  O  O   . CYS A 1 117 ? 2.90426  -5.70875  13.96769  1.000 22.51507 ? 117 CYS A O   1 
ATOM   903  C  CB  . CYS A 1 117 ? 3.28459  -7.93060  11.59824  1.000 24.74099 ? 117 CYS A CB  1 
ATOM   904  S  SG  . CYS A 1 117 ? 3.38494  -8.44350  9.88116   1.000 30.19700 ? 117 CYS A SG  1 
ATOM   905  N  N   . TYR A 1 118 ? 1.28992  -7.29085  13.92813  1.000 24.94734 ? 118 TYR A N   1 
ATOM   906  C  CA  . TYR A 1 118 ? 1.05205  -7.30429  15.36468  1.000 23.12616 ? 118 TYR A CA  1 
ATOM   907  C  C   . TYR A 1 118 ? 0.73168  -8.72976  15.77929  1.000 27.15604 ? 118 TYR A C   1 
ATOM   908  O  O   . TYR A 1 118 ? -0.09989 -9.38835  15.14879  1.000 26.60353 ? 118 TYR A O   1 
ATOM   909  C  CB  . TYR A 1 118 ? -0.08456 -6.34723  15.74787  1.000 25.00454 ? 118 TYR A CB  1 
ATOM   910  C  CG  . TYR A 1 118 ? 0.22452  -4.91518  15.36845  1.000 25.81478 ? 118 TYR A CG  1 
ATOM   911  C  CD1 . TYR A 1 118 ? 0.91798  -4.08180  16.23453  1.000 27.54555 ? 118 TYR A CD1 1 
ATOM   912  C  CD2 . TYR A 1 118 ? -0.14816 -4.40844  14.13013  1.000 26.61690 ? 118 TYR A CD2 1 
ATOM   913  C  CE1 . TYR A 1 118 ? 1.21769  -2.77875  15.88318  1.000 27.61263 ? 118 TYR A CE1 1 
ATOM   914  C  CE2 . TYR A 1 118 ? 0.14761  -3.10652  13.77108  1.000 27.30882 ? 118 TYR A CE2 1 
ATOM   915  C  CZ  . TYR A 1 118 ? 0.83029  -2.29770  14.65101  1.000 23.56666 ? 118 TYR A CZ  1 
ATOM   916  O  OH  . TYR A 1 118 ? 1.12681  -1.00200  14.29978  1.000 27.16174 ? 118 TYR A OH  1 
ATOM   917  N  N   . ASN A 1 119 ? 1.40644  -9.20772  16.82436  1.000 26.67819 ? 119 ASN A N   1 
ATOM   918  C  CA  . ASN A 1 119 ? 1.27902  -10.59768 17.25529  1.000 29.64909 ? 119 ASN A CA  1 
ATOM   919  C  C   . ASN A 1 119 ? 1.49381  -11.55045 16.08174  1.000 26.82786 ? 119 ASN A C   1 
ATOM   920  O  O   . ASN A 1 119 ? 0.83078  -12.58228 15.95744  1.000 27.34531 ? 119 ASN A O   1 
ATOM   921  C  CB  . ASN A 1 119 ? -0.07332 -10.84099 17.92327  1.000 32.64689 ? 119 ASN A CB  1 
ATOM   922  C  CG  . ASN A 1 119 ? -0.30583 -9.92666  19.10545  1.000 36.01453 ? 119 ASN A CG  1 
ATOM   923  O  OD1 . ASN A 1 119 ? -1.28862 -9.18698  19.14730  1.000 39.66725 ? 119 ASN A OD1 1 
ATOM   924  N  ND2 . ASN A 1 119 ? 0.60607  -9.96305  20.07164  1.000 33.73503 ? 119 ASN A ND2 1 
ATOM   925  N  N   . GLY A 1 120 ? 2.43320  -11.19262 15.20770  1.000 23.81289 ? 120 GLY A N   1 
ATOM   926  C  CA  . GLY A 1 120 ? 2.76596  -12.01466 14.06242  1.000 24.90816 ? 120 GLY A CA  1 
ATOM   927  C  C   . GLY A 1 120 ? 1.74141  -12.02223 12.95539  1.000 26.90872 ? 120 GLY A C   1 
ATOM   928  O  O   . GLY A 1 120 ? 1.90902  -12.76754 11.98507  1.000 25.08321 ? 120 GLY A O   1 
ATOM   929  N  N   . SER A 1 121 ? 0.68838  -11.21133 13.06672  1.000 24.83636 ? 121 SER A N   1 
ATOM   930  C  CA  . SER A 1 121 ? -0.39249 -11.17765 12.09763  1.000 28.61316 ? 121 SER A CA  1 
ATOM   931  C  C   . SER A 1 121 ? -0.32269 -9.90253  11.27205  1.000 26.43833 ? 121 SER A C   1 
ATOM   932  O  O   . SER A 1 121 ? -0.31547 -8.80137  11.83743  1.000 26.96227 ? 121 SER A O   1 
ATOM   933  C  CB  . SER A 1 121 ? -1.74853 -11.26917 12.80605  1.000 27.83512 ? 121 SER A CB  1 
ATOM   934  O  OG  . SER A 1 121 ? -2.80703 -11.36213 11.86967  1.000 37.13629 ? 121 SER A OG  1 
ATOM   935  N  N   . PRO A 1 122 ? -0.27190 -10.00995 9.94646   1.000 27.17846 ? 122 PRO A N   1 
ATOM   936  C  CA  . PRO A 1 122 ? -0.14313 -8.80942  9.10904   1.000 28.54325 ? 122 PRO A CA  1 
ATOM   937  C  C   . PRO A 1 122 ? -1.34044 -7.88107  9.26043   1.000 28.09984 ? 122 PRO A C   1 
ATOM   938  O  O   . PRO A 1 122 ? -2.49241 -8.31848  9.28558   1.000 29.70706 ? 122 PRO A O   1 
ATOM   939  C  CB  . PRO A 1 122 ? -0.05066 -9.38025  7.68841   1.000 28.96261 ? 122 PRO A CB  1 
ATOM   940  C  CG  . PRO A 1 122 ? 0.43849  -10.78847 7.87130   1.000 28.94256 ? 122 PRO A CG  1 
ATOM   941  C  CD  . PRO A 1 122 ? -0.18412 -11.25202 9.16177   1.000 27.17160 ? 122 PRO A CD  1 
ATOM   942  N  N   . SER A 1 123 ? -1.05547 -6.58300  9.34410   1.000 27.23696 ? 123 SER A N   1 
ATOM   943  C  CA  . SER A 1 123 ? -2.07410 -5.55342  9.52627   1.000 27.56799 ? 123 SER A CA  1 
ATOM   944  C  C   . SER A 1 123 ? -2.28079 -4.67299  8.30252   1.000 29.61461 ? 123 SER A C   1 
ATOM   945  O  O   . SER A 1 123 ? -3.41998 -4.32574  7.98471   1.000 27.65342 ? 123 SER A O   1 
ATOM   946  C  CB  . SER A 1 123 ? -1.71326 -4.66612  10.72397  1.000 27.68007 ? 123 SER A CB  1 
ATOM   947  O  OG  . SER A 1 123 ? -2.63083 -3.59642  10.86008  1.000 33.75382 ? 123 SER A OG  1 
ATOM   948  N  N   . GLY A 1 124 ? -1.21155 -4.29650  7.61354   1.000 23.96336 ? 124 GLY A N   1 
ATOM   949  C  CA  . GLY A 1 124 ? -1.32263 -3.41673  6.46260   1.000 22.26789 ? 124 GLY A CA  1 
ATOM   950  C  C   . GLY A 1 124 ? 0.03763  -3.23737  5.82667   1.000 27.26146 ? 124 GLY A C   1 
ATOM   951  O  O   . GLY A 1 124 ? 1.07248  -3.60052  6.39832   1.000 23.99881 ? 124 GLY A O   1 
ATOM   952  N  N   . VAL A 1 125 ? 0.02331  -2.66627  4.62457   1.000 23.95582 ? 125 VAL A N   1 
ATOM   953  C  CA  . VAL A 1 125 ? 1.23288  -2.48908  3.83213   1.000 23.69839 ? 125 VAL A CA  1 
ATOM   954  C  C   . VAL A 1 125 ? 1.27781  -1.06388  3.29876   1.000 23.40354 ? 125 VAL A C   1 
ATOM   955  O  O   . VAL A 1 125 ? 0.25698  -0.51728  2.86725   1.000 23.37891 ? 125 VAL A O   1 
ATOM   956  C  CB  . VAL A 1 125 ? 1.30882  -3.51203  2.67770   1.000 23.29777 ? 125 VAL A CB  1 
ATOM   957  C  CG1 . VAL A 1 125 ? 0.10564  -3.37166  1.75988   1.000 26.72169 ? 125 VAL A CG1 1 
ATOM   958  C  CG2 . VAL A 1 125 ? 2.60933  -3.35004  1.90528   1.000 26.08549 ? 125 VAL A CG2 1 
ATOM   959  N  N   . TYR A 1 126 ? 2.46336  -0.46042  3.33613   1.000 22.80199 ? 126 TYR A N   1 
ATOM   960  C  CA  . TYR A 1 126 ? 2.64983  0.87483   2.78631   1.000 24.54149 ? 126 TYR A CA  1 
ATOM   961  C  C   . TYR A 1 126 ? 4.10662  1.04295   2.38430   1.000 26.12729 ? 126 TYR A C   1 
ATOM   962  O  O   . TYR A 1 126 ? 4.99320  0.33887   2.87435   1.000 22.69818 ? 126 TYR A O   1 
ATOM   963  C  CB  . TYR A 1 126 ? 2.23106  1.96356   3.78094   1.000 25.15039 ? 126 TYR A CB  1 
ATOM   964  C  CG  . TYR A 1 126 ? 2.87187  1.83754   5.14413   1.000 23.84273 ? 126 TYR A CG  1 
ATOM   965  C  CD1 . TYR A 1 126 ? 4.07989  2.45927   5.42736   1.000 23.61681 ? 126 TYR A CD1 1 
ATOM   966  C  CD2 . TYR A 1 126 ? 2.26443  1.09665   6.14929   1.000 25.67041 ? 126 TYR A CD2 1 
ATOM   967  C  CE1 . TYR A 1 126 ? 4.66674  2.34706   6.67724   1.000 23.07572 ? 126 TYR A CE1 1 
ATOM   968  C  CE2 . TYR A 1 126 ? 2.84321  0.97805   7.39924   1.000 27.21258 ? 126 TYR A CE2 1 
ATOM   969  C  CZ  . TYR A 1 126 ? 4.04476  1.60506   7.65676   1.000 26.32499 ? 126 TYR A CZ  1 
ATOM   970  O  OH  . TYR A 1 126 ? 4.62033  1.48916   8.90199   1.000 26.46525 ? 126 TYR A OH  1 
ATOM   971  N  N   . GLN A 1 127 ? 4.33598  1.98927   1.48022   1.000 24.69714 ? 127 GLN A N   1 
ATOM   972  C  CA  . GLN A 1 127 ? 5.66365  2.30468   0.97711   1.000 24.45857 ? 127 GLN A CA  1 
ATOM   973  C  C   . GLN A 1 127 ? 6.23944  3.48355   1.75089   1.000 29.78575 ? 127 GLN A C   1 
ATOM   974  O  O   . GLN A 1 127 ? 5.52087  4.43140   2.07941   1.000 33.29403 ? 127 GLN A O   1 
ATOM   975  C  CB  . GLN A 1 127 ? 5.59976  2.63987   -0.51706  1.000 27.86835 ? 127 GLN A CB  1 
ATOM   976  C  CG  . GLN A 1 127 ? 6.93968  2.71048   -1.22418  1.000 29.42649 ? 127 GLN A CG  1 
ATOM   977  C  CD  . GLN A 1 127 ? 7.33525  1.39142   -1.85138  1.000 26.74843 ? 127 GLN A CD  1 
ATOM   978  O  OE1 . GLN A 1 127 ? 6.81435  0.33686   -1.48881  1.000 28.23416 ? 127 GLN A OE1 1 
ATOM   979  N  NE2 . GLN A 1 127 ? 8.25541  1.44330   -2.80450  1.000 31.14027 ? 127 GLN A NE2 1 
ATOM   980  N  N   . CYS A 1 128 ? 7.53478  3.42419   2.05027   1.000 27.69285 ? 128 CYS A N   1 
ATOM   981  C  CA  . CYS A 1 128 ? 8.21136  4.59196   2.59792   1.000 32.68370 ? 128 CYS A CA  1 
ATOM   982  C  C   . CYS A 1 128 ? 9.67894  4.56473   2.19564   1.000 28.57169 ? 128 CYS A C   1 
ATOM   983  O  O   . CYS A 1 128 ? 10.18619 3.57675   1.65715   1.000 28.81770 ? 128 CYS A O   1 
ATOM   984  C  CB  . CYS A 1 128 ? 8.04629  4.68729   4.11983   1.000 31.50608 ? 128 CYS A CB  1 
ATOM   985  S  SG  . CYS A 1 128 ? 8.45916  3.21342   5.04539   1.000 41.60451 ? 128 CYS A SG  1 
ATOM   986  N  N   . ALA A 1 129 ? 10.35351 5.67995   2.44670   1.000 24.73058 ? 129 ALA A N   1 
ATOM   987  C  CA  . ALA A 1 129 ? 11.73563 5.86569   2.04278   1.000 24.33561 ? 129 ALA A CA  1 
ATOM   988  C  C   . ALA A 1 129 ? 12.63705 5.95671   3.26446   1.000 22.42073 ? 129 ALA A C   1 
ATOM   989  O  O   . ALA A 1 129 ? 12.24571 6.48202   4.30957   1.000 22.23518 ? 129 ALA A O   1 
ATOM   990  C  CB  . ALA A 1 129 ? 11.89377 7.12997   1.19173   1.000 22.59197 ? 129 ALA A CB  1 
ATOM   991  N  N   . MET A 1 130 ? 13.84915 5.43153   3.12462   1.000 23.11482 ? 130 MET A N   1 
ATOM   992  C  CA  . MET A 1 130 ? 14.88733 5.65268   4.12388   1.000 20.34815 ? 130 MET A CA  1 
ATOM   993  C  C   . MET A 1 130 ? 15.33720 7.10535   4.02803   1.000 20.56498 ? 130 MET A C   1 
ATOM   994  O  O   . MET A 1 130 ? 15.93976 7.50888   3.02843   1.000 21.58406 ? 130 MET A O   1 
ATOM   995  C  CB  . MET A 1 130 ? 16.05102 4.69253   3.89279   1.000 22.81390 ? 130 MET A CB  1 
ATOM   996  C  CG  . MET A 1 130 ? 17.19306 4.81594   4.89377   1.000 22.06722 ? 130 MET A CG  1 
ATOM   997  S  SD  . MET A 1 130 ? 16.68210 4.45611   6.58647   1.000 28.17693 ? 130 MET A SD  1 
ATOM   998  C  CE  . MET A 1 130 ? 15.94042 2.83560   6.39154   1.000 26.11617 ? 130 MET A CE  1 
ATOM   999  N  N   . ARG A 1 131 ? 15.01490 7.90750   5.04254   1.000 19.74377 ? 131 ARG A N   1 
ATOM   1000 C  CA  . ARG A 1 131 ? 15.37711 9.31444   5.00223   1.000 21.06546 ? 131 ARG A CA  1 
ATOM   1001 C  C   . ARG A 1 131 ? 16.89684 9.46195   4.96579   1.000 20.74454 ? 131 ARG A C   1 
ATOM   1002 O  O   . ARG A 1 131 ? 17.62928 8.54865   5.35664   1.000 20.30691 ? 131 ARG A O   1 
ATOM   1003 C  CB  . ARG A 1 131 ? 14.80923 10.05593  6.21406   1.000 22.25290 ? 131 ARG A CB  1 
ATOM   1004 C  CG  . ARG A 1 131 ? 13.28957 10.01187  6.34814   1.000 23.79024 ? 131 ARG A CG  1 
ATOM   1005 C  CD  . ARG A 1 131 ? 12.58212 10.51783  5.09381   1.000 25.19835 ? 131 ARG A CD  1 
ATOM   1006 N  NE  . ARG A 1 131 ? 13.10602 11.79641  4.62596   1.000 23.37902 ? 131 ARG A NE  1 
ATOM   1007 C  CZ  . ARG A 1 131 ? 12.73322 12.39016  3.49919   1.000 26.10067 ? 131 ARG A CZ  1 
ATOM   1008 N  NH1 . ARG A 1 131 ? 11.81015 11.86031  2.71161   1.000 22.45441 ? 131 ARG A NH1 1 
ATOM   1009 N  NH2 . ARG A 1 131 ? 13.30558 13.54077  3.15042   1.000 22.02660 ? 131 ARG A NH2 1 
ATOM   1010 N  N   . PRO A 1 132 ? 17.39537 10.60166  4.47943   1.000 21.83222 ? 132 PRO A N   1 
ATOM   1011 C  CA  . PRO A 1 132 ? 18.84290 10.85105  4.55345   1.000 22.13088 ? 132 PRO A CA  1 
ATOM   1012 C  C   . PRO A 1 132 ? 19.41319 10.68723  5.94934   1.000 22.27310 ? 132 PRO A C   1 
ATOM   1013 O  O   . PRO A 1 132 ? 20.59262 10.33669  6.08720   1.000 22.33311 ? 132 PRO A O   1 
ATOM   1014 C  CB  . PRO A 1 132 ? 18.96701 12.29625  4.05562   1.000 24.02873 ? 132 PRO A CB  1 
ATOM   1015 C  CG  . PRO A 1 132 ? 17.82713 12.44589  3.10506   1.000 25.34593 ? 132 PRO A CG  1 
ATOM   1016 C  CD  . PRO A 1 132 ? 16.69611 11.64446  3.70734   1.000 22.62405 ? 132 PRO A CD  1 
ATOM   1017 N  N   . ASN A 1 133 ? 18.61919 10.93122  6.99318   1.000 23.22045 ? 133 ASN A N   1 
ATOM   1018 C  CA  . ASN A 1 133 ? 19.07874 10.75985  8.36537   1.000 23.67856 ? 133 ASN A CA  1 
ATOM   1019 C  C   . ASN A 1 133 ? 18.77322 9.36927   8.91491   1.000 23.91094 ? 133 ASN A C   1 
ATOM   1020 O  O   . ASN A 1 133 ? 18.76957 9.17988   10.13749  1.000 21.02371 ? 133 ASN A O   1 
ATOM   1021 C  CB  . ASN A 1 133 ? 18.48108 11.84361  9.26804   1.000 21.84630 ? 133 ASN A CB  1 
ATOM   1022 C  CG  . ASN A 1 133 ? 17.00233 11.64473  9.53690   1.000 23.17043 ? 133 ASN A CG  1 
ATOM   1023 O  OD1 . ASN A 1 133 ? 16.34962 10.79631  8.93083   1.000 23.41589 ? 133 ASN A OD1 1 
ATOM   1024 N  ND2 . ASN A 1 133 ? 16.46237 12.44299  10.45119  1.000 25.95211 ? 133 ASN A ND2 1 
ATOM   1025 N  N   . PHE A 1 134 ? 18.50922 8.40116   8.03661   1.000 21.56405 ? 134 PHE A N   1 
ATOM   1026 C  CA  . PHE A 1 134 ? 18.38346 6.99236   8.41472   1.000 24.04185 ? 134 PHE A CA  1 
ATOM   1027 C  C   . PHE A 1 134 ? 17.22502 6.74138   9.37648   1.000 25.48611 ? 134 PHE A C   1 
ATOM   1028 O  O   . PHE A 1 134 ? 17.24957 5.78476   10.15653  1.000 27.15056 ? 134 PHE A O   1 
ATOM   1029 C  CB  . PHE A 1 134 ? 19.69106 6.46259   9.00579   1.000 21.87937 ? 134 PHE A CB  1 
ATOM   1030 C  CG  . PHE A 1 134 ? 20.80874 6.38319   8.01034   1.000 23.87495 ? 134 PHE A CG  1 
ATOM   1031 C  CD1 . PHE A 1 134 ? 20.75752 5.47407   6.96698   1.000 23.83813 ? 134 PHE A CD1 1 
ATOM   1032 C  CD2 . PHE A 1 134 ? 21.90865 7.21766   8.11286   1.000 26.84940 ? 134 PHE A CD2 1 
ATOM   1033 C  CE1 . PHE A 1 134 ? 21.78202 5.39569   6.04550   1.000 28.08656 ? 134 PHE A CE1 1 
ATOM   1034 C  CE2 . PHE A 1 134 ? 22.93703 7.14502   7.19550   1.000 25.32262 ? 134 PHE A CE2 1 
ATOM   1035 C  CZ  . PHE A 1 134 ? 22.87474 6.23204   6.15945   1.000 30.36508 ? 134 PHE A CZ  1 
ATOM   1036 N  N   . THR A 1 135 ? 16.20891 7.59397   9.33921   1.000 23.46894 ? 135 THR A N   1 
ATOM   1037 C  CA  . THR A 1 135 ? 14.92138 7.31712   9.95654   1.000 21.61555 ? 135 THR A CA  1 
ATOM   1038 C  C   . THR A 1 135 ? 13.89822 7.04244   8.86169   1.000 24.29897 ? 135 THR A C   1 
ATOM   1039 O  O   . THR A 1 135 ? 14.15562 7.24246   7.66989   1.000 21.78625 ? 135 THR A O   1 
ATOM   1040 C  CB  . THR A 1 135 ? 14.45309 8.48823   10.83001  1.000 22.45294 ? 135 THR A CB  1 
ATOM   1041 O  OG1 . THR A 1 135 ? 14.23591 9.63677   10.00289  1.000 24.48532 ? 135 THR A OG1 1 
ATOM   1042 C  CG2 . THR A 1 135 ? 15.49024 8.82097   11.89915  1.000 22.40094 ? 135 THR A CG2 1 
ATOM   1043 N  N   . ILE A 1 136 ? 12.72402 6.57318   9.27253   1.000 21.26308 ? 136 ILE A N   1 
ATOM   1044 C  CA  . ILE A 1 136 ? 11.59782 6.41727   8.36274   1.000 21.86778 ? 136 ILE A CA  1 
ATOM   1045 C  C   . ILE A 1 136 ? 10.36181 6.97817   9.04332   1.000 24.61712 ? 136 ILE A C   1 
ATOM   1046 O  O   . ILE A 1 136 ? 10.21540 6.88449   10.26717  1.000 23.81344 ? 136 ILE A O   1 
ATOM   1047 C  CB  . ILE A 1 136 ? 11.37513 4.94878   7.93353   1.000 24.17140 ? 136 ILE A CB  1 
ATOM   1048 C  CG1 . ILE A 1 136 ? 10.86118 4.10324   9.09767   1.000 24.56900 ? 136 ILE A CG1 1 
ATOM   1049 C  CG2 . ILE A 1 136 ? 12.66394 4.34600   7.36653   1.000 23.45333 ? 136 ILE A CG2 1 
ATOM   1050 C  CD1 . ILE A 1 136 ? 10.56656 2.66473   8.71140   1.000 26.64791 ? 136 ILE A CD1 1 
ATOM   1051 N  N   . LYS A 1 137 ? 9.48363  7.58134   8.25184   1.000 28.41529 ? 137 LYS A N   1 
ATOM   1052 C  CA  . LYS A 1 137 ? 8.23195  8.13948   8.75574   1.000 26.57884 ? 137 LYS A CA  1 
ATOM   1053 C  C   . LYS A 1 137 ? 7.13569  7.14062   8.40710   1.000 31.51408 ? 137 LYS A C   1 
ATOM   1054 O  O   . LYS A 1 137 ? 6.52803  7.20779   7.34042   1.000 31.62418 ? 137 LYS A O   1 
ATOM   1055 C  CB  . LYS A 1 137 ? 7.96068  9.51259   8.15204   1.000 32.59363 ? 137 LYS A CB  1 
ATOM   1056 C  CG  . LYS A 1 137 ? 9.09931  10.50451  8.29891   1.000 33.65424 ? 137 LYS A CG  1 
ATOM   1057 C  CD  . LYS A 1 137 ? 8.68588  11.87039  7.76699   1.000 38.30367 ? 137 LYS A CD  1 
ATOM   1058 C  CE  . LYS A 1 137 ? 9.87667  12.80112  7.61242   1.000 39.63106 ? 137 LYS A CE  1 
ATOM   1059 N  NZ  . LYS A 1 137 ? 10.53355 13.09734  8.91428   1.000 41.18245 ? 137 LYS A NZ  1 
ATOM   1060 N  N   . GLY A 1 138 ? 6.88257  6.19691   9.31378   1.000 28.74631 ? 138 GLY A N   1 
ATOM   1061 C  CA  . GLY A 1 138 ? 5.92641  5.15053   9.08199   1.000 28.33296 ? 138 GLY A CA  1 
ATOM   1062 C  C   . GLY A 1 138 ? 4.68515  5.27841   9.93665   1.000 26.67232 ? 138 GLY A C   1 
ATOM   1063 O  O   . GLY A 1 138 ? 4.31195  6.36925   10.39375  1.000 29.71107 ? 138 GLY A O   1 
ATOM   1064 N  N   . SER A 1 139 ? 4.01973  4.14474   10.14559  1.000 26.67014 ? 139 SER A N   1 
ATOM   1065 C  CA  . SER A 1 139 ? 2.84583  4.05539   11.01316  1.000 25.48126 ? 139 SER A CA  1 
ATOM   1066 C  C   . SER A 1 139 ? 3.01399  2.79058   11.84676  1.000 26.40484 ? 139 SER A C   1 
ATOM   1067 O  O   . SER A 1 139 ? 2.74290  1.68549   11.36703  1.000 29.00533 ? 139 SER A O   1 
ATOM   1068 C  CB  . SER A 1 139 ? 1.55303  4.02745   10.20673  1.000 29.85038 ? 139 SER A CB  1 
ATOM   1069 O  OG  . SER A 1 139 ? 0.45466  3.65691   11.02111  1.000 29.74566 ? 139 SER A OG  1 
ATOM   1070 N  N   . PHE A 1 140 ? 3.46920  2.95685   13.08734  1.000 25.08678 ? 140 PHE A N   1 
ATOM   1071 C  CA  . PHE A 1 140 ? 3.81293  1.83310   13.94639  1.000 25.30956 ? 140 PHE A CA  1 
ATOM   1072 C  C   . PHE A 1 140 ? 3.25235  2.06602   15.34105  1.000 27.94029 ? 140 PHE A C   1 
ATOM   1073 O  O   . PHE A 1 140 ? 3.45087  3.13763   15.91921  1.000 28.46190 ? 140 PHE A O   1 
ATOM   1074 C  CB  . PHE A 1 140 ? 5.33344  1.63720   14.02800  1.000 23.24667 ? 140 PHE A CB  1 
ATOM   1075 C  CG  . PHE A 1 140 ? 5.95806  1.10429   12.76473  1.000 25.41530 ? 140 PHE A CG  1 
ATOM   1076 C  CD1 . PHE A 1 140 ? 5.70220  -0.18899  12.33871  1.000 22.66194 ? 140 PHE A CD1 1 
ATOM   1077 C  CD2 . PHE A 1 140 ? 6.82495  1.88825   12.02107  1.000 25.95596 ? 140 PHE A CD2 1 
ATOM   1078 C  CE1 . PHE A 1 140 ? 6.28733  -0.68495  11.18628  1.000 22.05658 ? 140 PHE A CE1 1 
ATOM   1079 C  CE2 . PHE A 1 140 ? 7.41312  1.39678   10.86481  1.000 23.54714 ? 140 PHE A CE2 1 
ATOM   1080 C  CZ  . PHE A 1 140 ? 7.14511  0.10913   10.45127  1.000 24.56950 ? 140 PHE A CZ  1 
ATOM   1081 N  N   . LEU A 1 141 ? 2.56929  1.06121   15.87764  1.000 25.98215 ? 141 LEU A N   1 
ATOM   1082 C  CA  . LEU A 1 141 ? 2.06103  1.07665   17.24114  1.000 28.53174 ? 141 LEU A CA  1 
ATOM   1083 C  C   . LEU A 1 141 ? 2.83212  0.06624   18.07897  1.000 28.16804 ? 141 LEU A C   1 
ATOM   1084 O  O   . LEU A 1 141 ? 3.57382  -0.76822  17.55772  1.000 25.97911 ? 141 LEU A O   1 
ATOM   1085 C  CB  . LEU A 1 141 ? 0.56046  0.76291   17.27077  1.000 28.66449 ? 141 LEU A CB  1 
ATOM   1086 C  CG  . LEU A 1 141 ? -0.34437 1.63143   16.39273  1.000 33.91251 ? 141 LEU A CG  1 
ATOM   1087 C  CD1 . LEU A 1 141 ? -1.74142 1.04221   16.33184  1.000 36.47259 ? 141 LEU A CD1 1 
ATOM   1088 C  CD2 . LEU A 1 141 ? -0.38610 3.06257   16.90879  1.000 33.08029 ? 141 LEU A CD2 1 
ATOM   1089 N  N   . ASN A 1 142 ? 2.65619  0.15144   19.39634  1.000 26.14850 ? 142 ASN A N   1 
ATOM   1090 C  CA  . ASN A 1 142 ? 3.26943  -0.82968  20.28050  1.000 29.50103 ? 142 ASN A CA  1 
ATOM   1091 C  C   . ASN A 1 142 ? 2.92384  -2.23469  19.80545  1.000 28.23020 ? 142 ASN A C   1 
ATOM   1092 O  O   . ASN A 1 142 ? 1.79105  -2.50918  19.40210  1.000 28.77171 ? 142 ASN A O   1 
ATOM   1093 C  CB  . ASN A 1 142 ? 2.80091  -0.62175  21.72323  1.000 30.09841 ? 142 ASN A CB  1 
ATOM   1094 C  CG  . ASN A 1 142 ? 3.52137  -1.52657  22.70742  1.000 37.41192 ? 142 ASN A CG  1 
ATOM   1095 O  OD1 . ASN A 1 142 ? 4.68019  -1.88746  22.50378  1.000 37.69015 ? 142 ASN A OD1 1 
ATOM   1096 N  ND2 . ASN A 1 142 ? 2.83319  -1.90195  23.78083  1.000 51.54895 ? 142 ASN A ND2 1 
ATOM   1097 N  N   . GLY A 1 143 ? 3.91563  -3.12322  19.83861  1.000 27.80147 ? 143 GLY A N   1 
ATOM   1098 C  CA  . GLY A 1 143 ? 3.76255  -4.45880  19.30721  1.000 24.53544 ? 143 GLY A CA  1 
ATOM   1099 C  C   . GLY A 1 143 ? 4.16207  -4.61622  17.85586  1.000 24.54836 ? 143 GLY A C   1 
ATOM   1100 O  O   . GLY A 1 143 ? 4.23745  -5.75254  17.36978  1.000 22.86272 ? 143 GLY A O   1 
ATOM   1101 N  N   . SER A 1 144 ? 4.42326  -3.51708  17.14891  1.000 22.26532 ? 144 SER A N   1 
ATOM   1102 C  CA  . SER A 1 144 ? 4.82107  -3.58646  15.75012  1.000 23.88981 ? 144 SER A CA  1 
ATOM   1103 C  C   . SER A 1 144 ? 6.26947  -4.01610  15.56407  1.000 21.68909 ? 144 SER A C   1 
ATOM   1104 O  O   . SER A 1 144 ? 6.66537  -4.32158  14.43438  1.000 19.33583 ? 144 SER A O   1 
ATOM   1105 C  CB  . SER A 1 144 ? 4.60027  -2.22998  15.07493  1.000 23.23390 ? 144 SER A CB  1 
ATOM   1106 O  OG  . SER A 1 144 ? 5.37153  -1.21957  15.70153  1.000 24.24319 ? 144 SER A OG  1 
ATOM   1107 N  N   . CYS A 1 145 ? 7.06425  -4.04591  16.63255  1.000 21.49609 ? 145 CYS A N   1 
ATOM   1108 C  CA  . CYS A 1 145 ? 8.46303  -4.43225  16.51282  1.000 20.28618 ? 145 CYS A CA  1 
ATOM   1109 C  C   . CYS A 1 145 ? 8.59138  -5.78625  15.83041  1.000 18.49767 ? 145 CYS A C   1 
ATOM   1110 O  O   . CYS A 1 145 ? 7.82657  -6.71541  16.10412  1.000 21.00314 ? 145 CYS A O   1 
ATOM   1111 C  CB  . CYS A 1 145 ? 9.11817  -4.46544  17.89336  1.000 24.71523 ? 145 CYS A CB  1 
ATOM   1112 S  SG  . CYS A 1 145 ? 9.20766  -2.84181  18.66285  1.000 29.85371 ? 145 CYS A SG  1 
ATOM   1113 N  N   . GLY A 1 146 ? 9.56472  -5.88739  14.92658  1.000 18.52039 ? 146 GLY A N   1 
ATOM   1114 C  CA  . GLY A 1 146 ? 9.76826  -7.08454  14.14067  1.000 19.97506 ? 146 GLY A CA  1 
ATOM   1115 C  C   . GLY A 1 146 ? 9.15174  -7.04026  12.76101  1.000 19.78501 ? 146 GLY A C   1 
ATOM   1116 O  O   . GLY A 1 146 ? 9.47259  -7.89667  11.92843  1.000 21.02170 ? 146 GLY A O   1 
ATOM   1117 N  N   . SER A 1 147 ? 8.27041  -6.08005  12.49760  1.000 20.93502 ? 147 SER A N   1 
ATOM   1118 C  CA  . SER A 1 147 ? 7.80155  -5.86892  11.13837  1.000 19.50113 ? 147 SER A CA  1 
ATOM   1119 C  C   . SER A 1 147 ? 8.98705  -5.55433  10.23285  1.000 19.22190 ? 147 SER A C   1 
ATOM   1120 O  O   . SER A 1 147 ? 9.98425  -4.97035  10.66292  1.000 20.97516 ? 147 SER A O   1 
ATOM   1121 C  CB  . SER A 1 147 ? 6.78460  -4.73020  11.10245  1.000 21.87728 ? 147 SER A CB  1 
ATOM   1122 O  OG  . SER A 1 147 ? 5.75286  -4.94220  12.05128  1.000 23.67536 ? 147 SER A OG  1 
ATOM   1123 N  N   . VAL A 1 148 ? 8.87989  -5.94135  8.96256   1.000 18.17917 ? 148 VAL A N   1 
ATOM   1124 C  CA  . VAL A 1 148 ? 10.01364 -5.82907  8.05577   1.000 16.95641 ? 148 VAL A CA  1 
ATOM   1125 C  C   . VAL A 1 148 ? 9.63949  -5.00926  6.82896   1.000 22.19999 ? 148 VAL A C   1 
ATOM   1126 O  O   . VAL A 1 148 ? 8.47309  -4.92817  6.42416   1.000 18.34225 ? 148 VAL A O   1 
ATOM   1127 C  CB  . VAL A 1 148 ? 10.55353 -7.21592  7.63847   1.000 20.78700 ? 148 VAL A CB  1 
ATOM   1128 C  CG1 . VAL A 1 148 ? 11.02770 -7.98344  8.86381   1.000 19.98823 ? 148 VAL A CG1 1 
ATOM   1129 C  CG2 . VAL A 1 148 ? 9.48883  -8.00620  6.88713   1.000 19.64119 ? 148 VAL A CG2 1 
ATOM   1130 N  N   . GLY A 1 149 ? 10.66198 -4.38845  6.24509   1.000 19.77286 ? 149 GLY A N   1 
ATOM   1131 C  CA  . GLY A 1 149 ? 10.55635 -3.72189  4.96221   1.000 19.36608 ? 149 GLY A CA  1 
ATOM   1132 C  C   . GLY A 1 149 ? 11.27224 -4.54213  3.90544   1.000 21.32094 ? 149 GLY A C   1 
ATOM   1133 O  O   . GLY A 1 149 ? 12.20426 -5.29141  4.20768   1.000 19.26628 ? 149 GLY A O   1 
ATOM   1134 N  N   . PHE A 1 150 ? 10.84457 -4.39058  2.65651   1.000 20.91620 ? 150 PHE A N   1 
ATOM   1135 C  CA  . PHE A 1 150 ? 11.33171 -5.27842  1.61139   1.000 22.02139 ? 150 PHE A CA  1 
ATOM   1136 C  C   . PHE A 1 150 ? 11.08044 -4.65344  0.24780   1.000 21.74158 ? 150 PHE A C   1 
ATOM   1137 O  O   . PHE A 1 150 ? 10.25653 -3.74880  0.09587   1.000 21.20074 ? 150 PHE A O   1 
ATOM   1138 C  CB  . PHE A 1 150 ? 10.64741 -6.64731  1.69726   1.000 19.71931 ? 150 PHE A CB  1 
ATOM   1139 C  CG  . PHE A 1 150 ? 9.15175  -6.57107  1.58001   1.000 21.73966 ? 150 PHE A CG  1 
ATOM   1140 C  CD1 . PHE A 1 150 ? 8.36890  -6.34676  2.69826   1.000 20.42312 ? 150 PHE A CD1 1 
ATOM   1141 C  CD2 . PHE A 1 150 ? 8.53124  -6.69204  0.34515   1.000 23.08417 ? 150 PHE A CD2 1 
ATOM   1142 C  CE1 . PHE A 1 150 ? 6.99200  -6.25509  2.59290   1.000 23.71778 ? 150 PHE A CE1 1 
ATOM   1143 C  CE2 . PHE A 1 150 ? 7.14787  -6.60834  0.23327   1.000 22.53389 ? 150 PHE A CE2 1 
ATOM   1144 C  CZ  . PHE A 1 150 ? 6.38070  -6.38757  1.35978   1.000 24.41313 ? 150 PHE A CZ  1 
ATOM   1145 N  N   . ASN A 1 151 ? 11.81473 -5.15193  -0.73942  1.000 21.50489 ? 151 ASN A N   1 
ATOM   1146 C  CA  . ASN A 1 151 ? 11.50622 -4.96303  -2.14642  1.000 23.46751 ? 151 ASN A CA  1 
ATOM   1147 C  C   . ASN A 1 151 ? 11.39899 -6.33584  -2.79788  1.000 25.07685 ? 151 ASN A C   1 
ATOM   1148 O  O   . ASN A 1 151 ? 11.90528 -7.33349  -2.27427  1.000 23.53247 ? 151 ASN A O   1 
ATOM   1149 C  CB  . ASN A 1 151 ? 12.57315 -4.12382  -2.85696  1.000 23.19490 ? 151 ASN A CB  1 
ATOM   1150 C  CG  . ASN A 1 151 ? 12.53170 -2.66384  -2.45879  1.000 29.06946 ? 151 ASN A CG  1 
ATOM   1151 O  OD1 . ASN A 1 151 ? 11.76801 -1.87471  -3.02052  1.000 27.64482 ? 151 ASN A OD1 1 
ATOM   1152 N  ND2 . ASN A 1 151 ? 13.35634 -2.29399  -1.48681  1.000 26.30854 ? 151 ASN A ND2 1 
ATOM   1153 N  N   . ILE A 1 152 ? 10.73206 -6.38781  -3.94701  1.000 25.44290 ? 152 ILE A N   1 
ATOM   1154 C  CA  . ILE A 1 152 ? 10.54028 -7.63561  -4.67775  1.000 27.27767 ? 152 ILE A CA  1 
ATOM   1155 C  C   . ILE A 1 152 ? 10.94384 -7.41952  -6.12890  1.000 30.87197 ? 152 ILE A C   1 
ATOM   1156 O  O   . ILE A 1 152 ? 10.49926 -6.45569  -6.76212  1.000 29.01276 ? 152 ILE A O   1 
ATOM   1157 C  CB  . ILE A 1 152 ? 9.08583  -8.13530  -4.59437  1.000 27.94182 ? 152 ILE A CB  1 
ATOM   1158 C  CG1 . ILE A 1 152 ? 8.60969  -8.15305  -3.14150  1.000 29.73063 ? 152 ILE A CG1 1 
ATOM   1159 C  CG2 . ILE A 1 152 ? 8.96462  -9.52313  -5.20887  1.000 26.90932 ? 152 ILE A CG2 1 
ATOM   1160 C  CD1 . ILE A 1 152 ? 7.24782  -8.79651  -2.95575  1.000 24.59271 ? 152 ILE A CD1 1 
ATOM   1161 N  N   . ASP A 1 153 ? 11.78860 -8.31096  -6.64860  1.000 33.61336 ? 153 ASP A N   1 
ATOM   1162 C  CA  . ASP A 1 153 ? 12.19778 -8.31299  -8.05396  1.000 35.72428 ? 153 ASP A CA  1 
ATOM   1163 C  C   . ASP A 1 153 ? 11.72867 -9.62860  -8.66762  1.000 38.29516 ? 153 ASP A C   1 
ATOM   1164 O  O   . ASP A 1 153 ? 12.34768 -10.67653 -8.45732  1.000 39.62161 ? 153 ASP A O   1 
ATOM   1165 C  CB  . ASP A 1 153 ? 13.70708 -8.13607  -8.19905  1.000 39.37311 ? 153 ASP A CB  1 
ATOM   1166 C  CG  . ASP A 1 153 ? 14.17728 -8.30876  -9.63328  1.000 46.21799 ? 153 ASP A CG  1 
ATOM   1167 O  OD1 . ASP A 1 153 ? 13.72034 -7.54055  -10.50658 1.000 47.73941 ? 153 ASP A OD1 1 
ATOM   1168 O  OD2 . ASP A 1 153 ? 14.99890 -9.21457  -9.88929  1.000 47.33506 ? 153 ASP A OD2 1 
ATOM   1169 N  N   . TYR A 1 154 ? 10.63755 -9.56662  -9.42945  1.000 34.93610 ? 154 TYR A N   1 
ATOM   1170 C  CA  . TYR A 1 154 ? 9.98230  -10.75702 -9.95757  1.000 43.94364 ? 154 TYR A CA  1 
ATOM   1171 C  C   . TYR A 1 154 ? 9.57638  -11.69014 -8.82251  1.000 42.55214 ? 154 TYR A C   1 
ATOM   1172 O  O   . TYR A 1 154 ? 8.48704  -11.55102 -8.25668  1.000 43.55266 ? 154 TYR A O   1 
ATOM   1173 C  CB  . TYR A 1 154 ? 10.88559 -11.48220 -10.96064 1.000 47.03957 ? 154 TYR A CB  1 
ATOM   1174 C  CG  . TYR A 1 154 ? 10.28130 -12.76015 -11.50967 1.000 53.30921 ? 154 TYR A CG  1 
ATOM   1175 C  CD1 . TYR A 1 154 ? 8.95112  -12.80649 -11.91025 1.000 55.87997 ? 154 TYR A CD1 1 
ATOM   1176 C  CD2 . TYR A 1 154 ? 11.04122 -13.91791 -11.62954 1.000 55.43273 ? 154 TYR A CD2 1 
ATOM   1177 C  CE1 . TYR A 1 154 ? 8.39317  -13.97100 -12.40871 1.000 60.00286 ? 154 TYR A CE1 1 
ATOM   1178 C  CE2 . TYR A 1 154 ? 10.49212 -15.08700 -12.12809 1.000 56.59547 ? 154 TYR A CE2 1 
ATOM   1179 C  CZ  . TYR A 1 154 ? 9.16840  -15.10739 -12.51581 1.000 61.22606 ? 154 TYR A CZ  1 
ATOM   1180 O  OH  . TYR A 1 154 ? 8.61842  -16.26756 -13.01276 1.000 66.71625 ? 154 TYR A OH  1 
ATOM   1181 N  N   . ASP A 1 155 ? 10.44307 -12.63916 -8.47609  1.000 44.01441 ? 155 ASP A N   1 
ATOM   1182 C  CA  . ASP A 1 155 ? 10.13817 -13.61529 -7.44151  1.000 43.42938 ? 155 ASP A CA  1 
ATOM   1183 C  C   . ASP A 1 155 ? 11.08463 -13.54999 -6.25130  1.000 39.43486 ? 155 ASP A C   1 
ATOM   1184 O  O   . ASP A 1 155 ? 10.91801 -14.32936 -5.30607  1.000 36.43628 ? 155 ASP A O   1 
ATOM   1185 C  CB  . ASP A 1 155 ? 10.14982 -15.03410 -8.03077  1.000 47.75801 ? 155 ASP A CB  1 
ATOM   1186 C  CG  . ASP A 1 155 ? 11.49174 -15.40633 -8.64051  1.000 50.82046 ? 155 ASP A CG  1 
ATOM   1187 O  OD1 . ASP A 1 155 ? 12.24823 -14.49248 -9.03512  1.000 51.51905 ? 155 ASP A OD1 1 
ATOM   1188 O  OD2 . ASP A 1 155 ? 11.78813 -16.61722 -8.72878  1.000 51.91915 ? 155 ASP A OD2 1 
ATOM   1189 N  N   . CYS A 1 156 ? 12.06102 -12.64764 -6.25959  1.000 35.95201 ? 156 CYS A N   1 
ATOM   1190 C  CA  . CYS A 1 156 ? 13.04551 -12.55173 -5.18981  1.000 34.95899 ? 156 CYS A CA  1 
ATOM   1191 C  C   . CYS A 1 156 ? 12.65313 -11.42968 -4.23645  1.000 31.81825 ? 156 CYS A C   1 
ATOM   1192 O  O   . CYS A 1 156 ? 12.48151 -10.27994 -4.65882  1.000 29.43847 ? 156 CYS A O   1 
ATOM   1193 C  CB  . CYS A 1 156 ? 14.44441 -12.30879 -5.75378  1.000 33.80061 ? 156 CYS A CB  1 
ATOM   1194 S  SG  . CYS A 1 156 ? 15.75462 -12.42205 -4.52114  1.000 36.95744 ? 156 CYS A SG  1 
ATOM   1195 N  N   . VAL A 1 157 ? 12.51400 -11.76648 -2.95817  1.000 27.48611 ? 157 VAL A N   1 
ATOM   1196 C  CA  . VAL A 1 157 ? 12.22388 -10.78767 -1.91687  1.000 27.32993 ? 157 VAL A CA  1 
ATOM   1197 C  C   . VAL A 1 157 ? 13.54254 -10.33782 -1.30466  1.000 22.74383 ? 157 VAL A C   1 
ATOM   1198 O  O   . VAL A 1 157 ? 14.28418 -11.15156 -0.74420  1.000 25.02436 ? 157 VAL A O   1 
ATOM   1199 C  CB  . VAL A 1 157 ? 11.29448 -11.37294 -0.84216  1.000 24.41883 ? 157 VAL A CB  1 
ATOM   1200 C  CG1 . VAL A 1 157 ? 11.03260 -10.34472 0.25403   1.000 21.11359 ? 157 VAL A CG1 1 
ATOM   1201 C  CG2 . VAL A 1 157 ? 9.98944  -11.84484 -1.46018  1.000 25.71040 ? 157 VAL A CG2 1 
ATOM   1202 N  N   . SER A 1 158 ? 13.84106 -9.04542  -1.41512  1.000 23.62947 ? 158 SER A N   1 
ATOM   1203 C  CA  . SER A 1 158 ? 15.00195 -8.44886  -0.76242  1.000 22.24769 ? 158 SER A CA  1 
ATOM   1204 C  C   . SER A 1 158 ? 14.52810 -7.77705  0.51996   1.000 21.34115 ? 158 SER A C   1 
ATOM   1205 O  O   . SER A 1 158 ? 13.86543 -6.73616  0.47236   1.000 21.94983 ? 158 SER A O   1 
ATOM   1206 C  CB  . SER A 1 158 ? 15.69932 -7.44465  -1.67882  1.000 25.05461 ? 158 SER A CB  1 
ATOM   1207 O  OG  . SER A 1 158 ? 16.49282 -8.10300  -2.64760  1.000 27.11238 ? 158 SER A OG  1 
ATOM   1208 N  N   . PHE A 1 159 ? 14.85414 -8.37762  1.66130   1.000 22.91095 ? 159 PHE A N   1 
ATOM   1209 C  CA  . PHE A 1 159 ? 14.53451 -7.77732  2.94920   1.000 21.02541 ? 159 PHE A CA  1 
ATOM   1210 C  C   . PHE A 1 159 ? 15.60398 -6.76052  3.31783   1.000 22.19477 ? 159 PHE A C   1 
ATOM   1211 O  O   . PHE A 1 159 ? 16.80081 -7.06037  3.27470   1.000 22.04517 ? 159 PHE A O   1 
ATOM   1212 C  CB  . PHE A 1 159 ? 14.43093 -8.84600  4.03747   1.000 20.09584 ? 159 PHE A CB  1 
ATOM   1213 C  CG  . PHE A 1 159 ? 13.32241 -9.83299  3.81609   1.000 19.65032 ? 159 PHE A CG  1 
ATOM   1214 C  CD1 . PHE A 1 159 ? 12.01072 -9.49849  4.10964   1.000 19.86165 ? 159 PHE A CD1 1 
ATOM   1215 C  CD2 . PHE A 1 159 ? 13.59245 -11.09856 3.32607   1.000 19.84960 ? 159 PHE A CD2 1 
ATOM   1216 C  CE1 . PHE A 1 159 ? 10.99010 -10.40542 3.90851   1.000 18.93570 ? 159 PHE A CE1 1 
ATOM   1217 C  CE2 . PHE A 1 159 ? 12.57458 -12.01110 3.12739   1.000 20.24662 ? 159 PHE A CE2 1 
ATOM   1218 C  CZ  . PHE A 1 159 ? 11.27135 -11.66231 3.41852   1.000 18.35498 ? 159 PHE A CZ  1 
ATOM   1219 N  N   . CYS A 1 160 ? 15.17330 -5.55865  3.69252   1.000 21.89793 ? 160 CYS A N   1 
ATOM   1220 C  CA  . CYS A 1 160 ? 16.10559 -4.48429  3.98618   1.000 19.53074 ? 160 CYS A CA  1 
ATOM   1221 C  C   . CYS A 1 160 ? 15.91180 -3.84186  5.34985   1.000 21.06228 ? 160 CYS A C   1 
ATOM   1222 O  O   . CYS A 1 160 ? 16.80479 -3.10848  5.78673   1.000 23.38698 ? 160 CYS A O   1 
ATOM   1223 C  CB  . CYS A 1 160 ? 16.01751 -3.38813  2.91095   1.000 20.16064 ? 160 CYS A CB  1 
ATOM   1224 S  SG  . CYS A 1 160 ? 14.37133 -2.67860  2.69355   1.000 20.91397 ? 160 CYS A SG  1 
ATOM   1225 N  N   . TYR A 1 161 ? 14.80181 -4.09456  6.04006   1.000 17.36072 ? 161 TYR A N   1 
ATOM   1226 C  CA  . TYR A 1 161 ? 14.50187 -3.35805  7.26002   1.000 18.43303 ? 161 TYR A CA  1 
ATOM   1227 C  C   . TYR A 1 161 ? 13.72905 -4.23525  8.23046   1.000 17.20820 ? 161 TYR A C   1 
ATOM   1228 O  O   . TYR A 1 161 ? 12.81658 -4.96258  7.83173   1.000 17.95964 ? 161 TYR A O   1 
ATOM   1229 C  CB  . TYR A 1 161 ? 13.69108 -2.09184  6.95105   1.000 17.02710 ? 161 TYR A CB  1 
ATOM   1230 C  CG  . TYR A 1 161 ? 13.32243 -1.25587  8.16397   1.000 19.41118 ? 161 TYR A CG  1 
ATOM   1231 C  CD1 . TYR A 1 161 ? 14.21200 -0.32436  8.68790   1.000 19.23376 ? 161 TYR A CD1 1 
ATOM   1232 C  CD2 . TYR A 1 161 ? 12.07637 -1.37885  8.76606   1.000 17.40722 ? 161 TYR A CD2 1 
ATOM   1233 C  CE1 . TYR A 1 161 ? 13.87345 0.45521   9.78989   1.000 18.62367 ? 161 TYR A CE1 1 
ATOM   1234 C  CE2 . TYR A 1 161 ? 11.73063 -0.60837  9.87158   1.000 15.99853 ? 161 TYR A CE2 1 
ATOM   1235 C  CZ  . TYR A 1 161 ? 12.63270 0.30504   10.37771  1.000 18.76259 ? 161 TYR A CZ  1 
ATOM   1236 O  OH  . TYR A 1 161 ? 12.29576 1.07530   11.47244  1.000 19.68365 ? 161 TYR A OH  1 
ATOM   1237 N  N   . MET A 1 162 ? 14.10091 -4.15384  9.50452   1.000 19.01130 ? 162 MET A N   1 
ATOM   1238 C  CA  . MET A 1 162 ? 13.29570 -4.67841  10.59910  1.000 17.47924 ? 162 MET A CA  1 
ATOM   1239 C  C   . MET A 1 162 ? 13.07179 -3.55037  11.59254  1.000 17.38093 ? 162 MET A C   1 
ATOM   1240 O  O   . MET A 1 162 ? 14.01616 -2.83749  11.95060  1.000 16.49408 ? 162 MET A O   1 
ATOM   1241 C  CB  . MET A 1 162 ? 13.96456 -5.87642  11.28319  1.000 17.41486 ? 162 MET A CB  1 
ATOM   1242 C  CG  . MET A 1 162 ? 13.20839 -6.38151  12.50501  1.000 17.62829 ? 162 MET A CG  1 
ATOM   1243 S  SD  . MET A 1 162 ? 13.79865 -7.97786  13.10726  1.000 23.28355 ? 162 MET A SD  1 
ATOM   1244 C  CE  . MET A 1 162 ? 13.00629 -9.10187  11.95553  1.000 20.01221 ? 162 MET A CE  1 
ATOM   1245 N  N   . HIS A 1 163 ? 11.82419 -3.37970  12.01903  1.000 18.72402 ? 163 HIS A N   1 
ATOM   1246 C  CA  . HIS A 1 163 ? 11.47523 -2.27301  12.89901  1.000 18.22171 ? 163 HIS A CA  1 
ATOM   1247 C  C   . HIS A 1 163 ? 11.86507 -2.57931  14.33959  1.000 18.10149 ? 163 HIS A C   1 
ATOM   1248 O  O   . HIS A 1 163 ? 11.63427 -3.68420  14.83870  1.000 17.68712 ? 163 HIS A O   1 
ATOM   1249 C  CB  . HIS A 1 163 ? 9.98049  -1.97835  12.81326  1.000 16.83767 ? 163 HIS A CB  1 
ATOM   1250 C  CG  . HIS A 1 163 ? 9.56875  -0.76459  13.57811  1.000 19.46326 ? 163 HIS A CG  1 
ATOM   1251 N  ND1 . HIS A 1 163 ? 10.18872 0.45620   13.42101  1.000 18.45807 ? 163 HIS A ND1 1 
ATOM   1252 C  CD2 . HIS A 1 163 ? 8.60583  -0.58243  14.51134  1.000 19.91999 ? 163 HIS A CD2 1 
ATOM   1253 C  CE1 . HIS A 1 163 ? 9.62100  1.33975   14.22187  1.000 22.36949 ? 163 HIS A CE1 1 
ATOM   1254 N  NE2 . HIS A 1 163 ? 8.65838  0.73517   14.89435  1.000 20.47336 ? 163 HIS A NE2 1 
ATOM   1255 N  N   . HIS A 1 164 ? 12.44198 -1.58392  15.01598  1.000 17.78183 ? 164 HIS A N   1 
ATOM   1256 C  CA  . HIS A 1 164 ? 12.92256 -1.75147  16.38427  1.000 20.47882 ? 164 HIS A CA  1 
ATOM   1257 C  C   . HIS A 1 164 ? 12.35878 -0.72935  17.36068  1.000 19.95408 ? 164 HIS A C   1 
ATOM   1258 O  O   . HIS A 1 164 ? 11.93516 -1.11102  18.45693  1.000 21.80268 ? 164 HIS A O   1 
ATOM   1259 C  CB  . HIS A 1 164 ? 14.45808 -1.69762  16.42071  1.000 17.50954 ? 164 HIS A CB  1 
ATOM   1260 C  CG  . HIS A 1 164 ? 15.12132 -2.96314  15.97329  1.000 18.51365 ? 164 HIS A CG  1 
ATOM   1261 N  ND1 . HIS A 1 164 ? 15.83084 -3.77456  16.83253  1.000 17.61462 ? 164 HIS A ND1 1 
ATOM   1262 C  CD2 . HIS A 1 164 ? 15.19530 -3.54992  14.75517  1.000 17.00817 ? 164 HIS A CD2 1 
ATOM   1263 C  CE1 . HIS A 1 164 ? 16.31226 -4.80729  16.16348  1.000 18.03401 ? 164 HIS A CE1 1 
ATOM   1264 N  NE2 . HIS A 1 164 ? 15.93776 -4.69716  14.90148  1.000 17.84964 ? 164 HIS A NE2 1 
ATOM   1265 N  N   . MET A 1 165 ? 12.34730 0.56098   17.01635  1.000 20.35471 ? 165 MET A N   1 
ATOM   1266 C  CA  . MET A 1 165 ? 11.99996 1.57672   18.00454  1.000 20.22178 ? 165 MET A CA  1 
ATOM   1267 C  C   . MET A 1 165 ? 11.31474 2.77221   17.36056  1.000 20.42615 ? 165 MET A C   1 
ATOM   1268 O  O   . MET A 1 165 ? 11.53862 3.08483   16.18933  1.000 19.71697 ? 165 MET A O   1 
ATOM   1269 C  CB  . MET A 1 165 ? 13.23499 2.09195   18.75347  1.000 20.34233 ? 165 MET A CB  1 
ATOM   1270 C  CG  . MET A 1 165 ? 14.08729 1.03684   19.40928  1.000 26.71000 ? 165 MET A CG  1 
ATOM   1271 S  SD  . MET A 1 165 ? 15.46090 1.81079   20.28623  1.000 30.06456 ? 165 MET A SD  1 
ATOM   1272 C  CE  . MET A 1 165 ? 16.23124 2.74410   18.96551  1.000 21.88329 ? 165 MET A CE  1 
ATOM   1273 N  N   . GLU A 1 166 ? 10.50691 3.46005   18.16220  1.000 19.60360 ? 166 GLU A N   1 
ATOM   1274 C  CA  . GLU A 1 166 ? 10.03400 4.80130   17.85528  1.000 22.03733 ? 166 GLU A CA  1 
ATOM   1275 C  C   . GLU A 1 166 ? 10.71499 5.77420   18.80836  1.000 22.74696 ? 166 GLU A C   1 
ATOM   1276 O  O   . GLU A 1 166 ? 10.70384 5.56361   20.02665  1.000 22.84130 ? 166 GLU A O   1 
ATOM   1277 C  CB  . GLU A 1 166 ? 8.51048  4.90051   17.97995  1.000 24.36897 ? 166 GLU A CB  1 
ATOM   1278 C  CG  . GLU A 1 166 ? 7.94797  6.27517   17.63833  1.000 23.79365 ? 166 GLU A CG  1 
ATOM   1279 C  CD  . GLU A 1 166 ? 6.43021  6.30976   17.64645  1.000 29.58661 ? 166 GLU A CD  1 
ATOM   1280 O  OE1 . GLU A 1 166 ? 5.80772  5.53229   16.89137  1.000 27.77590 ? 166 GLU A OE1 1 
ATOM   1281 O  OE2 . GLU A 1 166 ? 5.85700  7.11405   18.41034  1.000 32.43674 ? 166 GLU A OE2 1 
ATOM   1282 N  N   . LEU A 1 167 ? 11.32889 6.81496   18.25351  1.000 24.10762 ? 167 LEU A N   1 
ATOM   1283 C  CA  . LEU A 1 167 ? 12.01518 7.80601   19.06346  1.000 23.23603 ? 167 LEU A CA  1 
ATOM   1284 C  C   . LEU A 1 167 ? 11.01163 8.78315   19.66401  1.000 26.19123 ? 167 LEU A C   1 
ATOM   1285 O  O   . LEU A 1 167 ? 9.86553  8.86642   19.21759  1.000 25.66710 ? 167 LEU A O   1 
ATOM   1286 C  CB  . LEU A 1 167 ? 13.04529 8.55719   18.22449  1.000 25.15106 ? 167 LEU A CB  1 
ATOM   1287 C  CG  . LEU A 1 167 ? 14.13126 7.73407   17.52274  1.000 23.41496 ? 167 LEU A CG  1 
ATOM   1288 C  CD1 . LEU A 1 167 ? 15.07692 8.64841   16.75958  1.000 24.58339 ? 167 LEU A CD1 1 
ATOM   1289 C  CD2 . LEU A 1 167 ? 14.90053 6.87410   18.51560  1.000 31.65724 ? 167 LEU A CD2 1 
ATOM   1290 N  N   . PRO A 1 168 ? 11.41976 9.53308   20.68824  1.000 27.98291 ? 168 PRO A N   1 
ATOM   1291 C  CA  . PRO A 1 168 ? 10.49644 10.48577  21.32116  1.000 25.45693 ? 168 PRO A CA  1 
ATOM   1292 C  C   . PRO A 1 168 ? 9.88328  11.45918  20.32614  1.000 28.13552 ? 168 PRO A C   1 
ATOM   1293 O  O   . PRO A 1 168 ? 8.78896  11.98486  20.55173  1.000 28.72080 ? 168 PRO A O   1 
ATOM   1294 C  CB  . PRO A 1 168 ? 11.38714 11.20917  22.33872  1.000 26.76147 ? 168 PRO A CB  1 
ATOM   1295 C  CG  . PRO A 1 168 ? 12.48445 10.24732  22.62685  1.000 29.57140 ? 168 PRO A CG  1 
ATOM   1296 C  CD  . PRO A 1 168 ? 12.73671 9.50972   21.34607  1.000 27.68258 ? 168 PRO A CD  1 
ATOM   1297 N  N   . THR A 1 169 ? 10.58235 11.69801  19.21644  1.000 27.80601 ? 169 THR A N   1 
ATOM   1298 C  CA  . THR A 1 169 ? 10.10924 12.59345  18.17055  1.000 27.11623 ? 169 THR A CA  1 
ATOM   1299 C  C   . THR A 1 169 ? 9.03550  11.96894  17.28990  1.000 30.46613 ? 169 THR A C   1 
ATOM   1300 O  O   . THR A 1 169 ? 8.44727  12.67667  16.46475  1.000 29.78651 ? 169 THR A O   1 
ATOM   1301 C  CB  . THR A 1 169 ? 11.28548 13.03578  17.29871  1.000 28.56439 ? 169 THR A CB  1 
ATOM   1302 O  OG1 . THR A 1 169 ? 11.95859 11.87826  16.78904  1.000 28.12709 ? 169 THR A OG1 1 
ATOM   1303 C  CG2 . THR A 1 169 ? 12.26724 13.86564  18.11177  1.000 26.44921 ? 169 THR A CG2 1 
ATOM   1304 N  N   . GLY A 1 170 ? 8.76438  10.67486  17.44093  1.000 26.42145 ? 170 GLY A N   1 
ATOM   1305 C  CA  . GLY A 1 170 ? 7.75881  10.01338  16.64079  1.000 26.85769 ? 170 GLY A CA  1 
ATOM   1306 C  C   . GLY A 1 170 ? 8.26859  9.35834   15.37745  1.000 25.10024 ? 170 GLY A C   1 
ATOM   1307 O  O   . GLY A 1 170 ? 7.46505  8.78380   14.63319  1.000 25.30091 ? 170 GLY A O   1 
ATOM   1308 N  N   . VAL A 1 171 ? 9.56917  9.42314   15.10832  1.000 28.15548 ? 171 VAL A N   1 
ATOM   1309 C  CA  . VAL A 1 171 ? 10.13662 8.78619   13.92978  1.000 28.70589 ? 171 VAL A CA  1 
ATOM   1310 C  C   . VAL A 1 171 ? 10.56000 7.36801   14.28933  1.000 24.31853 ? 171 VAL A C   1 
ATOM   1311 O  O   . VAL A 1 171 ? 10.70607 7.00857   15.46077  1.000 27.49852 ? 171 VAL A O   1 
ATOM   1312 C  CB  . VAL A 1 171 ? 11.31576 9.59417   13.35283  1.000 27.39456 ? 171 VAL A CB  1 
ATOM   1313 C  CG1 . VAL A 1 171 ? 10.84857 10.98457  12.94723  1.000 32.34894 ? 171 VAL A CG1 1 
ATOM   1314 C  CG2 . VAL A 1 171 ? 12.44513 9.67529   14.35978  1.000 27.10992 ? 171 VAL A CG2 1 
ATOM   1315 N  N   . HIS A 1 172 ? 10.76571 6.55085   13.26427  1.000 22.63003 ? 172 HIS A N   1 
ATOM   1316 C  CA  . HIS A 1 172 ? 10.96332 5.12070   13.43239  1.000 20.59224 ? 172 HIS A CA  1 
ATOM   1317 C  C   . HIS A 1 172 ? 12.34584 4.72212   12.93601  1.000 20.40590 ? 172 HIS A C   1 
ATOM   1318 O  O   . HIS A 1 172 ? 12.81228 5.20984   11.90035  1.000 20.77953 ? 172 HIS A O   1 
ATOM   1319 C  CB  . HIS A 1 172 ? 9.86355  4.35089   12.69289  1.000 22.58175 ? 172 HIS A CB  1 
ATOM   1320 C  CG  . HIS A 1 172 ? 8.48223  4.80357   13.05384  1.000 22.96970 ? 172 HIS A CG  1 
ATOM   1321 N  ND1 . HIS A 1 172 ? 7.63399  5.40913   12.15176  1.000 22.29187 ? 172 HIS A ND1 1 
ATOM   1322 C  CD2 . HIS A 1 172 ? 7.81449  4.76821   14.23158  1.000 25.42669 ? 172 HIS A CD2 1 
ATOM   1323 C  CE1 . HIS A 1 172 ? 6.49581  5.70816   12.75205  1.000 23.14796 ? 172 HIS A CE1 1 
ATOM   1324 N  NE2 . HIS A 1 172 ? 6.58177  5.33557   14.01677  1.000 26.78729 ? 172 HIS A NE2 1 
ATOM   1325 N  N   . VAL A 1 173 ? 13.00122 3.84135   13.68977  1.000 18.91619 ? 173 VAL A N   1 
ATOM   1326 C  CA  . VAL A 1 173 ? 14.36524 3.42272   13.40004  1.000 17.40758 ? 173 VAL A CA  1 
ATOM   1327 C  C   . VAL A 1 173 ? 14.45162 1.91145   13.53415  1.000 18.24001 ? 173 VAL A C   1 
ATOM   1328 O  O   . VAL A 1 173 ? 13.70052 1.29014   14.29145  1.000 19.33185 ? 173 VAL A O   1 
ATOM   1329 C  CB  . VAL A 1 173 ? 15.39042 4.11409   14.32590  1.000 19.07541 ? 173 VAL A CB  1 
ATOM   1330 C  CG1 . VAL A 1 173 ? 15.42574 5.60788   14.04663  1.000 20.42248 ? 173 VAL A CG1 1 
ATOM   1331 C  CG2 . VAL A 1 173 ? 15.05971 3.84314   15.78747  1.000 18.04041 ? 173 VAL A CG2 1 
ATOM   1332 N  N   . GLY A 1 174 ? 15.37350 1.32196   12.78648  1.000 18.99155 ? 174 GLY A N   1 
ATOM   1333 C  CA  . GLY A 1 174 ? 15.50553 -0.11765  12.79147  1.000 18.61197 ? 174 GLY A CA  1 
ATOM   1334 C  C   . GLY A 1 174 ? 16.81555 -0.54878  12.17812  1.000 19.15064 ? 174 GLY A C   1 
ATOM   1335 O  O   . GLY A 1 174 ? 17.72129 0.25921   11.96016  1.000 20.65268 ? 174 GLY A O   1 
ATOM   1336 N  N   . THR A 1 175 ? 16.89167 -1.84189  11.88554  1.000 16.72280 ? 175 THR A N   1 
ATOM   1337 C  CA  . THR A 1 175 ? 18.11822 -2.49186  11.46022  1.000 19.95444 ? 175 THR A CA  1 
ATOM   1338 C  C   . THR A 1 175 ? 17.90984 -3.17760  10.11546  1.000 18.86533 ? 175 THR A C   1 
ATOM   1339 O  O   . THR A 1 175 ? 16.77980 -3.37763  9.65549   1.000 16.84494 ? 175 THR A O   1 
ATOM   1340 C  CB  . THR A 1 175 ? 18.57613 -3.52648  12.50043  1.000 18.90937 ? 175 THR A CB  1 
ATOM   1341 O  OG1 . THR A 1 175 ? 17.65073 -4.62183  12.51627  1.000 18.47047 ? 175 THR A OG1 1 
ATOM   1342 C  CG2 . THR A 1 175 ? 18.63747 -2.90457  13.89796  1.000 17.74989 ? 175 THR A CG2 1 
ATOM   1343 N  N   . ASP A 1 176 ? 19.02370 -3.53782  9.48221   1.000 20.61813 ? 176 ASP A N   1 
ATOM   1344 C  CA  . ASP A 1 176 ? 18.96735 -4.51751  8.41024   1.000 20.39102 ? 176 ASP A CA  1 
ATOM   1345 C  C   . ASP A 1 176 ? 18.83774 -5.90491  9.03435   1.000 19.91564 ? 176 ASP A C   1 
ATOM   1346 O  O   . ASP A 1 176 ? 18.82719 -6.06026  10.25717  1.000 19.21054 ? 176 ASP A O   1 
ATOM   1347 C  CB  . ASP A 1 176 ? 20.18544 -4.39122  7.49402   1.000 21.67136 ? 176 ASP A CB  1 
ATOM   1348 C  CG  . ASP A 1 176 ? 21.50302 -4.65968  8.20588   1.000 22.91471 ? 176 ASP A CG  1 
ATOM   1349 O  OD1 . ASP A 1 176 ? 21.52184 -5.38924  9.21895   1.000 23.03712 ? 176 ASP A OD1 1 
ATOM   1350 O  OD2 . ASP A 1 176 ? 22.53495 -4.13405  7.73798   1.000 25.21529 ? 176 ASP A OD2 1 
ATOM   1351 N  N   . LEU A 1 177 ? 18.72738 -6.93204  8.20041   1.000 21.07585 ? 177 LEU A N   1 
ATOM   1352 C  CA  . LEU A 1 177 ? 18.45548 -8.26111  8.73312   1.000 21.38309 ? 177 LEU A CA  1 
ATOM   1353 C  C   . LEU A 1 177 ? 19.68000 -8.92510  9.34875   1.000 24.75109 ? 177 LEU A C   1 
ATOM   1354 O  O   . LEU A 1 177 ? 19.56299 -10.04602 9.85545   1.000 23.35766 ? 177 LEU A O   1 
ATOM   1355 C  CB  . LEU A 1 177 ? 17.85843 -9.16061  7.64814   1.000 23.49355 ? 177 LEU A CB  1 
ATOM   1356 C  CG  . LEU A 1 177 ? 16.33096 -9.09730  7.56367   1.000 25.83942 ? 177 LEU A CG  1 
ATOM   1357 C  CD1 . LEU A 1 177 ? 15.70230 -9.60884  8.85869   1.000 21.66008 ? 177 LEU A CD1 1 
ATOM   1358 C  CD2 . LEU A 1 177 ? 15.85704 -7.68275  7.26701   1.000 22.66540 ? 177 LEU A CD2 1 
ATOM   1359 N  N   . GLU A 1 178 ? 20.84285 -8.27564  9.32075   1.000 23.80668 ? 178 GLU A N   1 
ATOM   1360 C  CA  . GLU A 1 178 ? 21.98503 -8.70398  10.11427  1.000 22.31371 ? 178 GLU A CA  1 
ATOM   1361 C  C   . GLU A 1 178 ? 22.07178 -7.95848  11.43859  1.000 22.10606 ? 178 GLU A C   1 
ATOM   1362 O  O   . GLU A 1 178 ? 23.07763 -8.08179  12.14372  1.000 21.38575 ? 178 GLU A O   1 
ATOM   1363 C  CB  . GLU A 1 178 ? 23.28433 -8.53165  9.32637   1.000 28.45509 ? 178 GLU A CB  1 
ATOM   1364 C  CG  . GLU A 1 178 ? 23.42741 -9.49715  8.15822   1.000 30.97460 ? 178 GLU A CG  1 
ATOM   1365 C  CD  . GLU A 1 178 ? 24.80666 -9.45021  7.52742   1.000 36.82403 ? 178 GLU A CD  1 
ATOM   1366 O  OE1 . GLU A 1 178 ? 25.66256 -8.68368  8.01775   1.000 39.67977 ? 178 GLU A OE1 1 
ATOM   1367 O  OE2 . GLU A 1 178 ? 25.03403 -10.18130 6.54215   1.000 36.33612 ? 178 GLU A OE2 1 
ATOM   1368 N  N   . GLY A 1 179 ? 21.04206 -7.18651  11.78575  1.000 21.11474 ? 179 GLY A N   1 
ATOM   1369 C  CA  . GLY A 1 179 ? 20.96169 -6.54166  13.08109  1.000 18.60033 ? 179 GLY A CA  1 
ATOM   1370 C  C   . GLY A 1 179 ? 21.72510 -5.24595  13.21479  1.000 21.79123 ? 179 GLY A C   1 
ATOM   1371 O  O   . GLY A 1 179 ? 21.83492 -4.72764  14.33094  1.000 21.77969 ? 179 GLY A O   1 
ATOM   1372 N  N   . ASN A 1 180 ? 22.25936 -4.70625  12.12136  1.000 22.51449 ? 180 ASN A N   1 
ATOM   1373 C  CA  . ASN A 1 180 ? 22.97304 -3.43600  12.15109  1.000 21.57701 ? 180 ASN A CA  1 
ATOM   1374 C  C   . ASN A 1 180 ? 21.97939 -2.29797  11.95258  1.000 21.47441 ? 180 ASN A C   1 
ATOM   1375 O  O   . ASN A 1 180 ? 21.26713 -2.25755  10.94289  1.000 21.57989 ? 180 ASN A O   1 
ATOM   1376 C  CB  . ASN A 1 180 ? 24.05153 -3.39320  11.07076  1.000 24.34988 ? 180 ASN A CB  1 
ATOM   1377 C  CG  . ASN A 1 180 ? 25.07409 -4.49497  11.22556  1.000 26.85243 ? 180 ASN A CG  1 
ATOM   1378 O  OD1 . ASN A 1 180 ? 25.90721 -4.45985  12.13016  1.000 26.68673 ? 180 ASN A OD1 1 
ATOM   1379 N  ND2 . ASN A 1 180 ? 25.02667 -5.47540  10.33269  1.000 26.40789 ? 180 ASN A ND2 1 
ATOM   1380 N  N   . PHE A 1 181 ? 21.93369 -1.37667  12.91026  1.000 21.26374 ? 181 PHE A N   1 
ATOM   1381 C  CA  . PHE A 1 181 ? 21.01662 -0.25328  12.80573  1.000 20.30704 ? 181 PHE A CA  1 
ATOM   1382 C  C   . PHE A 1 181 ? 21.35854 0.61504   11.60214  1.000 19.21184 ? 181 PHE A C   1 
ATOM   1383 O  O   . PHE A 1 181 ? 22.52893 0.81134   11.26400  1.000 20.79127 ? 181 PHE A O   1 
ATOM   1384 C  CB  . PHE A 1 181 ? 21.05932 0.59522   14.07895  1.000 20.75382 ? 181 PHE A CB  1 
ATOM   1385 C  CG  . PHE A 1 181 ? 19.94093 0.30890   15.03863  1.000 19.39100 ? 181 PHE A CG  1 
ATOM   1386 C  CD1 . PHE A 1 181 ? 18.71090 0.93492   14.89484  1.000 18.84128 ? 181 PHE A CD1 1 
ATOM   1387 C  CD2 . PHE A 1 181 ? 20.11854 -0.57940  16.08947  1.000 20.20789 ? 181 PHE A CD2 1 
ATOM   1388 C  CE1 . PHE A 1 181 ? 17.67848 0.67656   15.77569  1.000 20.26875 ? 181 PHE A CE1 1 
ATOM   1389 C  CE2 . PHE A 1 181 ? 19.09012 -0.84269  16.97910  1.000 18.90760 ? 181 PHE A CE2 1 
ATOM   1390 C  CZ  . PHE A 1 181 ? 17.86800 -0.21654  16.82279  1.000 20.10467 ? 181 PHE A CZ  1 
ATOM   1391 N  N   . TYR A 1 182 ? 20.32179 1.12095   10.94450  1.000 18.19115 ? 182 TYR A N   1 
ATOM   1392 C  CA  . TYR A 1 182 ? 20.47061 2.28548   10.08772  1.000 19.46146 ? 182 TYR A CA  1 
ATOM   1393 C  C   . TYR A 1 182 ? 20.57825 3.51805   10.97499  1.000 23.00622 ? 182 TYR A C   1 
ATOM   1394 O  O   . TYR A 1 182 ? 19.72697 3.74224   11.84132  1.000 23.68020 ? 182 TYR A O   1 
ATOM   1395 C  CB  . TYR A 1 182 ? 19.28063 2.41914   9.13901   1.000 21.44009 ? 182 TYR A CB  1 
ATOM   1396 C  CG  . TYR A 1 182 ? 19.17156 1.31616   8.11210   1.000 22.90652 ? 182 TYR A CG  1 
ATOM   1397 C  CD1 . TYR A 1 182 ? 19.88022 1.38458   6.91909   1.000 22.60345 ? 182 TYR A CD1 1 
ATOM   1398 C  CD2 . TYR A 1 182 ? 18.34886 0.21548   8.32657   1.000 17.16177 ? 182 TYR A CD2 1 
ATOM   1399 C  CE1 . TYR A 1 182 ? 19.78334 0.38598   5.97262   1.000 23.68364 ? 182 TYR A CE1 1 
ATOM   1400 C  CE2 . TYR A 1 182 ? 18.24288 -0.79239  7.37845   1.000 19.28119 ? 182 TYR A CE2 1 
ATOM   1401 C  CZ  . TYR A 1 182 ? 18.96412 -0.69759  6.20504   1.000 22.29185 ? 182 TYR A CZ  1 
ATOM   1402 O  OH  . TYR A 1 182 ? 18.87448 -1.68392  5.25397   1.000 22.22167 ? 182 TYR A OH  1 
ATOM   1403 N  N   . GLY A 1 183 ? 21.62978 4.30334   10.77667  1.000 23.71742 ? 183 GLY A N   1 
ATOM   1404 C  CA  . GLY A 1 183 ? 21.82669 5.50383   11.55127  1.000 21.06759 ? 183 GLY A CA  1 
ATOM   1405 C  C   . GLY A 1 183 ? 22.59755 5.25354   12.83130  1.000 25.75073 ? 183 GLY A C   1 
ATOM   1406 O  O   . GLY A 1 183 ? 23.10454 4.15486   13.07823  1.000 22.87741 ? 183 GLY A O   1 
ATOM   1407 N  N   . PRO A 1 184 ? 22.69827 6.28177   13.67622  1.000 26.83004 ? 184 PRO A N   1 
ATOM   1408 C  CA  . PRO A 1 184 ? 23.50562 6.18361   14.89684  1.000 25.21418 ? 184 PRO A CA  1 
ATOM   1409 C  C   . PRO A 1 184 ? 22.80429 5.52507   16.07380  1.000 26.93500 ? 184 PRO A C   1 
ATOM   1410 O  O   . PRO A 1 184 ? 23.35216 5.53769   17.17899  1.000 28.81586 ? 184 PRO A O   1 
ATOM   1411 C  CB  . PRO A 1 184 ? 23.80033 7.65877   15.20702  1.000 24.79930 ? 184 PRO A CB  1 
ATOM   1412 C  CG  . PRO A 1 184 ? 22.57193 8.36504   14.74197  1.000 26.55914 ? 184 PRO A CG  1 
ATOM   1413 C  CD  . PRO A 1 184 ? 22.12348 7.62739   13.49840  1.000 25.43433 ? 184 PRO A CD  1 
ATOM   1414 N  N   . PHE A 1 185 ? 21.63168 4.93778   15.87056  1.000 23.51796 ? 185 PHE A N   1 
ATOM   1415 C  CA  . PHE A 1 185 ? 20.76473 4.58126   16.97933  1.000 25.77584 ? 185 PHE A CA  1 
ATOM   1416 C  C   . PHE A 1 185 ? 21.19200 3.26350   17.62940  1.000 22.60334 ? 185 PHE A C   1 
ATOM   1417 O  O   . PHE A 1 185 ? 21.84253 2.41398   17.01641  1.000 23.70416 ? 185 PHE A O   1 
ATOM   1418 C  CB  . PHE A 1 185 ? 19.31779 4.51535   16.49113  1.000 22.97778 ? 185 PHE A CB  1 
ATOM   1419 C  CG  . PHE A 1 185 ? 18.93171 5.68418   15.62423  1.000 22.51620 ? 185 PHE A CG  1 
ATOM   1420 C  CD1 . PHE A 1 185 ? 18.71296 6.93489   16.18225  1.000 21.70280 ? 185 PHE A CD1 1 
ATOM   1421 C  CD2 . PHE A 1 185 ? 18.81905 5.54110   14.25084  1.000 23.51815 ? 185 PHE A CD2 1 
ATOM   1422 C  CE1 . PHE A 1 185 ? 18.36951 8.01543   15.38897  1.000 24.85558 ? 185 PHE A CE1 1 
ATOM   1423 C  CE2 . PHE A 1 185 ? 18.47497 6.61782   13.45331  1.000 23.40624 ? 185 PHE A CE2 1 
ATOM   1424 C  CZ  . PHE A 1 185 ? 18.24847 7.85648   14.02433  1.000 22.52690 ? 185 PHE A CZ  1 
ATOM   1425 N  N   . VAL A 1 186 ? 20.81888 3.11596   18.90335  1.000 24.89374 ? 186 VAL A N   1 
ATOM   1426 C  CA  . VAL A 1 186 ? 21.09438 1.92778   19.70143  1.000 24.64363 ? 186 VAL A CA  1 
ATOM   1427 C  C   . VAL A 1 186 ? 19.81106 1.51937   20.41022  1.000 25.39864 ? 186 VAL A C   1 
ATOM   1428 O  O   . VAL A 1 186 ? 18.96850 2.36169   20.73708  1.000 27.09007 ? 186 VAL A O   1 
ATOM   1429 C  CB  . VAL A 1 186 ? 22.22302 2.17079   20.72745  1.000 25.61071 ? 186 VAL A CB  1 
ATOM   1430 C  CG1 . VAL A 1 186 ? 23.53008 2.49181   20.01714  1.000 24.57289 ? 186 VAL A CG1 1 
ATOM   1431 C  CG2 . VAL A 1 186 ? 21.83578 3.29622   21.67003  1.000 22.83299 ? 186 VAL A CG2 1 
ATOM   1432 N  N   . ASP A 1 187 ? 19.66358 0.21562   20.65746  1.000 22.12507 ? 187 ASP A N   1 
ATOM   1433 C  CA  . ASP A 1 187 ? 18.42926 -0.30951  21.24362  1.000 23.45698 ? 187 ASP A CA  1 
ATOM   1434 C  C   . ASP A 1 187 ? 18.46234 -0.19418  22.77264  1.000 26.89481 ? 187 ASP A C   1 
ATOM   1435 O  O   . ASP A 1 187 ? 18.40351 -1.17339  23.51619  1.000 26.50222 ? 187 ASP A O   1 
ATOM   1436 C  CB  . ASP A 1 187 ? 18.17288 -1.74020  20.77706  1.000 21.66847 ? 187 ASP A CB  1 
ATOM   1437 C  CG  . ASP A 1 187 ? 19.38993 -2.64302  20.90805  1.000 25.71722 ? 187 ASP A CG  1 
ATOM   1438 O  OD1 . ASP A 1 187 ? 20.47672 -2.15518  21.28383  1.000 25.84764 ? 187 ASP A OD1 1 
ATOM   1439 O  OD2 . ASP A 1 187 ? 19.25353 -3.85597  20.63062  1.000 24.32104 ? 187 ASP A OD2 1 
ATOM   1440 N  N   . ARG A 1 188 ? 18.54957 1.05852   23.22587  1.000 27.14875 ? 188 ARG A N   1 
ATOM   1441 C  CA  . ARG A 1 188 ? 18.46133 1.43931   24.62934  1.000 30.58455 ? 188 ARG A CA  1 
ATOM   1442 C  C   . ARG A 1 188 ? 17.51681 2.62458   24.75845  1.000 31.08006 ? 188 ARG A C   1 
ATOM   1443 O  O   . ARG A 1 188 ? 17.50415 3.50880   23.89874  1.000 28.48393 ? 188 ARG A O   1 
ATOM   1444 C  CB  . ARG A 1 188 ? 19.81954 1.84462   25.20400  1.000 30.63375 ? 188 ARG A CB  1 
ATOM   1445 C  CG  . ARG A 1 188 ? 20.83292 0.73955   25.39819  1.000 39.88635 ? 188 ARG A CG  1 
ATOM   1446 C  CD  . ARG A 1 188 ? 22.12130 1.34668   25.94368  1.000 41.00563 ? 188 ARG A CD  1 
ATOM   1447 N  NE  . ARG A 1 188 ? 21.86231 2.16676   27.12309  1.000 48.21321 ? 188 ARG A NE  1 
ATOM   1448 C  CZ  . ARG A 1 188 ? 22.68826 3.09023   27.59874  1.000 50.10888 ? 188 ARG A CZ  1 
ATOM   1449 N  NH1 . ARG A 1 188 ? 23.84043 3.36044   27.00628  1.000 51.57893 ? 188 ARG A NH1 1 
ATOM   1450 N  NH2 . ARG A 1 188 ? 22.34603 3.76472   28.69306  1.000 46.52426 ? 188 ARG A NH2 1 
ATOM   1451 N  N   . GLN A 1 189 ? 16.73941 2.65720   25.84095  1.000 32.68839 ? 189 GLN A N   1 
ATOM   1452 C  CA  . GLN A 1 189 ? 15.87930 3.80804   26.11945  1.000 33.08091 ? 189 GLN A CA  1 
ATOM   1453 C  C   . GLN A 1 189 ? 16.72677 4.89716   26.77328  1.000 32.28656 ? 189 GLN A C   1 
ATOM   1454 O  O   . GLN A 1 189 ? 16.69643 5.13058   27.98506  1.000 30.33542 ? 189 GLN A O   1 
ATOM   1455 C  CB  . GLN A 1 189 ? 14.69411 3.41637   26.99144  1.000 37.01935 ? 189 GLN A CB  1 
ATOM   1456 C  CG  . GLN A 1 189 ? 13.75062 4.57598   27.27480  1.000 34.57963 ? 189 GLN A CG  1 
ATOM   1457 C  CD  . GLN A 1 189 ? 12.44333 4.13149   27.89683  1.000 37.86938 ? 189 GLN A CD  1 
ATOM   1458 O  OE1 . GLN A 1 189 ? 12.24109 2.94810   28.16742  1.000 42.59593 ? 189 GLN A OE1 1 
ATOM   1459 N  NE2 . GLN A 1 189 ? 11.54339 5.08183   28.12224  1.000 35.33358 ? 189 GLN A NE2 1 
ATOM   1460 N  N   . THR A 1 190 ? 17.51364 5.56600   25.93895  1.000 33.34991 ? 190 THR A N   1 
ATOM   1461 C  CA  . THR A 1 190 ? 18.32686 6.69423   26.35770  1.000 30.27433 ? 190 THR A CA  1 
ATOM   1462 C  C   . THR A 1 190 ? 18.24259 7.76273   25.27818  1.000 31.94727 ? 190 THR A C   1 
ATOM   1463 O  O   . THR A 1 190 ? 17.85808 7.48926   24.13725  1.000 28.53315 ? 190 THR A O   1 
ATOM   1464 C  CB  . THR A 1 190 ? 19.78671 6.28407   26.60521  1.000 31.81460 ? 190 THR A CB  1 
ATOM   1465 O  OG1 . THR A 1 190 ? 20.49459 7.36881   27.21803  1.000 39.24775 ? 190 THR A OG1 1 
ATOM   1466 C  CG2 . THR A 1 190 ? 20.47080 5.91609   25.29836  1.000 33.29201 ? 190 THR A CG2 1 
ATOM   1467 N  N   . ALA A 1 191 ? 18.59497 8.99112   25.65074  1.000 28.16104 ? 191 ALA A N   1 
ATOM   1468 C  CA  . ALA A 1 191 ? 18.52157 10.09682  24.70496  1.000 32.86521 ? 191 ALA A CA  1 
ATOM   1469 C  C   . ALA A 1 191 ? 19.37808 9.80407   23.48045  1.000 27.64337 ? 191 ALA A C   1 
ATOM   1470 O  O   . ALA A 1 191 ? 20.53920 9.40510   23.59958  1.000 25.76488 ? 191 ALA A O   1 
ATOM   1471 C  CB  . ALA A 1 191 ? 18.97350 11.39767  25.36907  1.000 32.06007 ? 191 ALA A CB  1 
ATOM   1472 N  N   . GLN A 1 192 ? 18.79574 9.98870   22.29850  1.000 32.17513 ? 192 GLN A N   1 
ATOM   1473 C  CA  . GLN A 1 192 ? 19.54707 9.84702   21.05422  1.000 31.66197 ? 192 GLN A CA  1 
ATOM   1474 C  C   . GLN A 1 192 ? 18.82554 10.62197  19.96735  1.000 33.04000 ? 192 GLN A C   1 
ATOM   1475 O  O   . GLN A 1 192 ? 17.63885 10.38736  19.71822  1.000 37.18845 ? 192 GLN A O   1 
ATOM   1476 C  CB  . GLN A 1 192 ? 19.71234 8.37632   20.66368  1.000 31.90059 ? 192 GLN A CB  1 
ATOM   1477 C  CG  . GLN A 1 192 ? 18.45923 7.52900   20.79403  1.000 30.39566 ? 192 GLN A CG  1 
ATOM   1478 C  CD  . GLN A 1 192 ? 18.75239 6.04353   20.65944  1.000 32.04053 ? 192 GLN A CD  1 
ATOM   1479 O  OE1 . GLN A 1 192 ? 19.37171 5.60626   19.68709  1.000 30.35226 ? 192 GLN A OE1 1 
ATOM   1480 N  NE2 . GLN A 1 192 ? 18.32041 5.26102   21.64537  1.000 27.65339 ? 192 GLN A NE2 1 
ATOM   1481 N  N   . ALA A 1 193 ? 19.53460 11.54040  19.32957  1.000 32.43048 ? 193 ALA A N   1 
ATOM   1482 C  CA  . ALA A 1 193 ? 18.95509 12.40344  18.31612  1.000 36.53844 ? 193 ALA A CA  1 
ATOM   1483 C  C   . ALA A 1 193 ? 19.23924 11.85635  16.92566  1.000 26.73638 ? 193 ALA A C   1 
ATOM   1484 O  O   . ALA A 1 193 ? 20.27899 11.24199  16.67751  1.000 28.33170 ? 193 ALA A O   1 
ATOM   1485 C  CB  . ALA A 1 193 ? 19.50627 13.82562  18.43022  1.000 37.24990 ? 193 ALA A CB  1 
ATOM   1486 N  N   . ALA A 1 194 ? 18.29082 12.07662  16.02323  1.000 30.29415 ? 194 ALA A N   1 
ATOM   1487 C  CA  . ALA A 1 194 ? 18.50201 11.83671  14.60603  1.000 25.96780 ? 194 ALA A CA  1 
ATOM   1488 C  C   . ALA A 1 194 ? 19.15389 13.06468  13.98587  1.000 26.94357 ? 194 ALA A C   1 
ATOM   1489 O  O   . ALA A 1 194 ? 18.84346 14.20049  14.35625  1.000 27.45047 ? 194 ALA A O   1 
ATOM   1490 C  CB  . ALA A 1 194 ? 17.17845 11.52965  13.90403  1.000 26.76250 ? 194 ALA A CB  1 
ATOM   1491 N  N   . GLY A 1 195 ? 20.06793 12.83526  13.05341  1.000 29.15528 ? 195 GLY A N   1 
ATOM   1492 C  CA  . GLY A 1 195 ? 20.72694 13.94077  12.38557  1.000 29.99248 ? 195 GLY A CA  1 
ATOM   1493 C  C   . GLY A 1 195 ? 19.73442 14.86618  11.70286  1.000 30.70819 ? 195 GLY A C   1 
ATOM   1494 O  O   . GLY A 1 195 ? 18.54540 14.57756  11.55713  1.000 25.21126 ? 195 GLY A O   1 
ATOM   1495 N  N   . THR A 1 196 ? 20.24261 16.02556  11.29093  1.000 28.05284 ? 196 THR A N   1 
ATOM   1496 C  CA  . THR A 1 196 ? 19.45844 16.89387  10.42511  1.000 26.38516 ? 196 THR A CA  1 
ATOM   1497 C  C   . THR A 1 196 ? 19.03076 16.10859  9.19394   1.000 25.74355 ? 196 THR A C   1 
ATOM   1498 O  O   . THR A 1 196 ? 19.83651 15.39004  8.59430   1.000 26.15913 ? 196 THR A O   1 
ATOM   1499 C  CB  . THR A 1 196 ? 20.26887 18.12255  10.00465  1.000 25.75216 ? 196 THR A CB  1 
ATOM   1500 O  OG1 . THR A 1 196 ? 20.87147 18.72751  11.15455  1.000 33.18276 ? 196 THR A OG1 1 
ATOM   1501 C  CG2 . THR A 1 196 ? 19.36660 19.14170  9.32272   1.000 28.56342 ? 196 THR A CG2 1 
ATOM   1502 N  N   . ASP A 1 197 ? 17.75974 16.22396  8.82870   1.000 25.46014 ? 197 ASP A N   1 
ATOM   1503 C  CA  . ASP A 1 197 ? 17.28360 15.57490  7.61759   1.000 28.26742 ? 197 ASP A CA  1 
ATOM   1504 C  C   . ASP A 1 197 ? 17.31370 16.55715  6.45401   1.000 29.82029 ? 197 ASP A C   1 
ATOM   1505 O  O   . ASP A 1 197 ? 17.35555 17.77688  6.63591   1.000 29.28332 ? 197 ASP A O   1 
ATOM   1506 C  CB  . ASP A 1 197 ? 15.86733 15.02523  7.79688   1.000 24.37581 ? 197 ASP A CB  1 
ATOM   1507 C  CG  . ASP A 1 197 ? 15.52834 13.94675  6.77632   1.000 25.44717 ? 197 ASP A CG  1 
ATOM   1508 O  OD1 . ASP A 1 197 ? 16.46506 13.29316  6.27085   1.000 23.59209 ? 197 ASP A OD1 1 
ATOM   1509 O  OD2 . ASP A 1 197 ? 14.33009 13.75279  6.47455   1.000 24.50959 ? 197 ASP A OD2 1 
ATOM   1510 N  N   . THR A 1 198 ? 17.29700 16.00514  5.24413   1.000 27.27929 ? 198 THR A N   1 
ATOM   1511 C  CA  . THR A 1 198 ? 17.25718 16.80685  4.03369   1.000 24.40965 ? 198 THR A CA  1 
ATOM   1512 C  C   . THR A 1 198 ? 16.27709 16.16580  3.06161   1.000 26.33991 ? 198 THR A C   1 
ATOM   1513 O  O   . THR A 1 198 ? 15.82240 15.03519  3.25751   1.000 25.77207 ? 198 THR A O   1 
ATOM   1514 C  CB  . THR A 1 198 ? 18.65090 16.95042  3.40059   1.000 29.06891 ? 198 THR A CB  1 
ATOM   1515 O  OG1 . THR A 1 198 ? 19.18666 15.65521  3.10839   1.000 30.77815 ? 198 THR A OG1 1 
ATOM   1516 C  CG2 . THR A 1 198 ? 19.59549 17.67619  4.34630   1.000 30.15549 ? 198 THR A CG2 1 
ATOM   1517 N  N   . THR A 1 199 ? 15.93793 16.91019  2.01327   1.000 27.45221 ? 199 THR A N   1 
ATOM   1518 C  CA  . THR A 1 199 ? 15.04494 16.41631  0.97585   1.000 25.35975 ? 199 THR A CA  1 
ATOM   1519 C  C   . THR A 1 199 ? 15.84285 15.68768  -0.09767  1.000 23.48547 ? 199 THR A C   1 
ATOM   1520 O  O   . THR A 1 199 ? 16.95859 16.09186  -0.43860  1.000 24.09325 ? 199 THR A O   1 
ATOM   1521 C  CB  . THR A 1 199 ? 14.24927 17.56660  0.36035   1.000 23.87045 ? 199 THR A CB  1 
ATOM   1522 O  OG1 . THR A 1 199 ? 13.46252 18.19124  1.38234   1.000 25.13874 ? 199 THR A OG1 1 
ATOM   1523 C  CG2 . THR A 1 199 ? 13.32767 17.05505  -0.73491  1.000 22.88136 ? 199 THR A CG2 1 
ATOM   1524 N  N   . ILE A 1 200 ? 15.26485 14.60816  -0.61980  1.000 19.26245 ? 200 ILE A N   1 
ATOM   1525 C  CA  . ILE A 1 200 ? 15.93204 13.73993  -1.58908  1.000 22.03170 ? 200 ILE A CA  1 
ATOM   1526 C  C   . ILE A 1 200 ? 15.72350 14.35734  -2.97010  1.000 20.90606 ? 200 ILE A C   1 
ATOM   1527 O  O   . ILE A 1 200 ? 14.69467 14.14332  -3.61546  1.000 18.85148 ? 200 ILE A O   1 
ATOM   1528 C  CB  . ILE A 1 200 ? 15.41011 12.30351  -1.51825  1.000 17.29896 ? 200 ILE A CB  1 
ATOM   1529 C  CG1 . ILE A 1 200 ? 15.47447 11.79588  -0.07516  1.000 21.62653 ? 200 ILE A CG1 1 
ATOM   1530 C  CG2 . ILE A 1 200 ? 16.22312 11.38663  -2.42602  1.000 21.66092 ? 200 ILE A CG2 1 
ATOM   1531 C  CD1 . ILE A 1 200 ? 14.66241 10.54055  0.17136   1.000 21.94598 ? 200 ILE A CD1 1 
ATOM   1532 N  N   . THR A 1 201 ? 16.71678 15.12133  -3.42939  1.000 22.84597 ? 201 THR A N   1 
ATOM   1533 C  CA  . THR A 1 201 ? 16.56203 15.91334  -4.64633  1.000 21.71974 ? 201 THR A CA  1 
ATOM   1534 C  C   . THR A 1 201 ? 16.24488 15.03758  -5.85445  1.000 21.09822 ? 201 THR A C   1 
ATOM   1535 O  O   . THR A 1 201 ? 15.33423 15.34389  -6.63231  1.000 20.37469 ? 201 THR A O   1 
ATOM   1536 C  CB  . THR A 1 201 ? 17.82853 16.73226  -4.89318  1.000 23.70357 ? 201 THR A CB  1 
ATOM   1537 O  OG1 . THR A 1 201 ? 18.14727 17.48095  -3.71248  1.000 20.77543 ? 201 THR A OG1 1 
ATOM   1538 C  CG2 . THR A 1 201 ? 17.62727 17.68944  -6.06551  1.000 20.76413 ? 201 THR A CG2 1 
ATOM   1539 N  N   . VAL A 1 202 ? 16.99129 13.94470  -6.03801  1.000 19.57007 ? 202 VAL A N   1 
ATOM   1540 C  CA  . VAL A 1 202 ? 16.79744 13.12993  -7.23760  1.000 18.81968 ? 202 VAL A CA  1 
ATOM   1541 C  C   . VAL A 1 202 ? 15.39052 12.54893  -7.27783  1.000 22.45824 ? 202 VAL A C   1 
ATOM   1542 O  O   . VAL A 1 202 ? 14.81119 12.37715  -8.35820  1.000 21.08912 ? 202 VAL A O   1 
ATOM   1543 C  CB  . VAL A 1 202 ? 17.86600 12.02256  -7.32027  1.000 20.15583 ? 202 VAL A CB  1 
ATOM   1544 C  CG1 . VAL A 1 202 ? 17.67020 11.00755  -6.20606  1.000 24.75308 ? 202 VAL A CG1 1 
ATOM   1545 C  CG2 . VAL A 1 202 ? 17.82241 11.34228  -8.68581  1.000 19.81210 ? 202 VAL A CG2 1 
ATOM   1546 N  N   . ASN A 1 203 ? 14.81574 12.24434  -6.11131  1.000 20.97271 ? 203 ASN A N   1 
ATOM   1547 C  CA  . ASN A 1 203 ? 13.45037 11.72705  -6.06161  1.000 20.38918 ? 203 ASN A CA  1 
ATOM   1548 C  C   . ASN A 1 203 ? 12.43138 12.80626  -6.40391  1.000 20.26342 ? 203 ASN A C   1 
ATOM   1549 O  O   . ASN A 1 203 ? 11.42136 12.52652  -7.06172  1.000 23.53712 ? 203 ASN A O   1 
ATOM   1550 C  CB  . ASN A 1 203 ? 13.16060 11.14438  -4.67779  1.000 20.20707 ? 203 ASN A CB  1 
ATOM   1551 C  CG  . ASN A 1 203 ? 13.92822 9.87000   -4.41111  1.000 22.08961 ? 203 ASN A CG  1 
ATOM   1552 O  OD1 . ASN A 1 203 ? 14.73269 9.43051   -5.23298  1.000 22.39799 ? 203 ASN A OD1 1 
ATOM   1553 N  ND2 . ASN A 1 203 ? 13.68670 9.26790   -3.25315  1.000 20.96232 ? 203 ASN A ND2 1 
ATOM   1554 N  N   . VAL A 1 204 ? 12.66462 14.04036  -5.95359  1.000 20.59504 ? 204 VAL A N   1 
ATOM   1555 C  CA  . VAL A 1 204 ? 11.76675 15.13389  -6.31452  1.000 18.90864 ? 204 VAL A CA  1 
ATOM   1556 C  C   . VAL A 1 204 ? 11.75522 15.32453  -7.82504  1.000 22.34941 ? 204 VAL A C   1 
ATOM   1557 O  O   . VAL A 1 204 ? 10.69462 15.51175  -8.43430  1.000 21.20162 ? 204 VAL A O   1 
ATOM   1558 C  CB  . VAL A 1 204 ? 12.16527 16.43033  -5.58451  1.000 21.28891 ? 204 VAL A CB  1 
ATOM   1559 C  CG1 . VAL A 1 204 ? 11.29983 17.58649  -6.06017  1.000 20.66261 ? 204 VAL A CG1 1 
ATOM   1560 C  CG2 . VAL A 1 204 ? 12.04187 16.26023  -4.06709  1.000 19.99944 ? 204 VAL A CG2 1 
ATOM   1561 N  N   . LEU A 1 205 ? 12.93392 15.26852  -8.45227  1.000 18.89112 ? 205 LEU A N   1 
ATOM   1562 C  CA  . LEU A 1 205 ? 13.01912 15.41102  -9.90320  1.000 24.00340 ? 205 LEU A CA  1 
ATOM   1563 C  C   . LEU A 1 205 ? 12.30262 14.26792  -10.61187 1.000 20.15040 ? 205 LEU A C   1 
ATOM   1564 O  O   . LEU A 1 205 ? 11.53218 14.49098  -11.55291 1.000 24.08344 ? 205 LEU A O   1 
ATOM   1565 C  CB  . LEU A 1 205 ? 14.48631 15.48301  -10.33219 1.000 21.18422 ? 205 LEU A CB  1 
ATOM   1566 C  CG  . LEU A 1 205 ? 15.21499 16.73765  -9.84789  1.000 21.31426 ? 205 LEU A CG  1 
ATOM   1567 C  CD1 . LEU A 1 205 ? 16.72329 16.58660  -9.99606  1.000 28.12751 ? 205 LEU A CD1 1 
ATOM   1568 C  CD2 . LEU A 1 205 ? 14.71373 17.96209  -10.60471 1.000 20.56665 ? 205 LEU A CD2 1 
ATOM   1569 N  N   . ALA A 1 206 ? 12.55070 13.03019  -10.17635 1.000 22.85948 ? 206 ALA A N   1 
ATOM   1570 C  CA  . ALA A 1 206 ? 11.84681 11.88995  -10.75620 1.000 23.83026 ? 206 ALA A CA  1 
ATOM   1571 C  C   . ALA A 1 206 ? 10.33765 12.06240  -10.63912 1.000 24.95510 ? 206 ALA A C   1 
ATOM   1572 O  O   . ALA A 1 206 ? 9.58767  11.70458  -11.55656 1.000 23.89958 ? 206 ALA A O   1 
ATOM   1573 C  CB  . ALA A 1 206 ? 12.29447 10.59470  -10.07695 1.000 21.55612 ? 206 ALA A CB  1 
ATOM   1574 N  N   . TRP A 1 207 ? 9.87755  12.61688  -9.51650  1.000 19.03191 ? 207 TRP A N   1 
ATOM   1575 C  CA  . TRP A 1 207 ? 8.44815  12.81681  -9.30308  1.000 24.15144 ? 207 TRP A CA  1 
ATOM   1576 C  C   . TRP A 1 207 ? 7.89444  13.87870  -10.24495 1.000 22.65340 ? 207 TRP A C   1 
ATOM   1577 O  O   . TRP A 1 207 ? 6.75192  13.77262  -10.70885 1.000 23.38810 ? 207 TRP A O   1 
ATOM   1578 C  CB  . TRP A 1 207 ? 8.20514  13.18884  -7.83873  1.000 20.68087 ? 207 TRP A CB  1 
ATOM   1579 C  CG  . TRP A 1 207 ? 6.79761  13.56362  -7.47345  1.000 23.59816 ? 207 TRP A CG  1 
ATOM   1580 C  CD1 . TRP A 1 207 ? 5.72799  12.72208  -7.33742  1.000 24.09911 ? 207 TRP A CD1 1 
ATOM   1581 C  CD2 . TRP A 1 207 ? 6.32034  14.87359  -7.14017  1.000 23.19920 ? 207 TRP A CD2 1 
ATOM   1582 N  NE1 . TRP A 1 207 ? 4.61365  13.43254  -6.96328  1.000 23.09381 ? 207 TRP A NE1 1 
ATOM   1583 C  CE2 . TRP A 1 207 ? 4.95092  14.75450  -6.83411  1.000 22.52909 ? 207 TRP A CE2 1 
ATOM   1584 C  CE3 . TRP A 1 207 ? 6.91761  16.13750  -7.07984  1.000 24.82596 ? 207 TRP A CE3 1 
ATOM   1585 C  CZ2 . TRP A 1 207 ? 4.16962  15.85002  -6.47501  1.000 22.34845 ? 207 TRP A CZ2 1 
ATOM   1586 C  CZ3 . TRP A 1 207 ? 6.13813  17.22499  -6.72689  1.000 22.88623 ? 207 TRP A CZ3 1 
ATOM   1587 C  CH2 . TRP A 1 207 ? 4.78071  17.07388  -6.42850  1.000 24.04195 ? 207 TRP A CH2 1 
ATOM   1588 N  N   . LEU A 1 208 ? 8.68900  14.90910  -10.54037 1.000 23.66889 ? 208 LEU A N   1 
ATOM   1589 C  CA  . LEU A 1 208 ? 8.26999  15.90208  -11.52334 1.000 23.19744 ? 208 LEU A CA  1 
ATOM   1590 C  C   . LEU A 1 208 ? 8.17198  15.28936  -12.91562 1.000 23.03974 ? 208 LEU A C   1 
ATOM   1591 O  O   . LEU A 1 208 ? 7.27561  15.64071  -13.69124 1.000 21.98017 ? 208 LEU A O   1 
ATOM   1592 C  CB  . LEU A 1 208 ? 9.23445  17.08781  -11.51502 1.000 23.17899 ? 208 LEU A CB  1 
ATOM   1593 C  CG  . LEU A 1 208 ? 9.20353  17.94501  -10.24906 1.000 23.06342 ? 208 LEU A CG  1 
ATOM   1594 C  CD1 . LEU A 1 208 ? 10.29767 18.99828  -10.28474 1.000 25.39786 ? 208 LEU A CD1 1 
ATOM   1595 C  CD2 . LEU A 1 208 ? 7.83602  18.59500  -10.06725 1.000 23.32764 ? 208 LEU A CD2 1 
ATOM   1596 N  N   . TYR A 1 209 ? 9.08277  14.37201  -13.25247 1.000 21.87416 ? 209 TYR A N   1 
ATOM   1597 C  CA  . TYR A 1 209 ? 8.95599  13.64675  -14.51333 1.000 22.90002 ? 209 TYR A CA  1 
ATOM   1598 C  C   . TYR A 1 209 ? 7.67281  12.82518  -14.54467 1.000 26.68379 ? 209 TYR A C   1 
ATOM   1599 O  O   . TYR A 1 209 ? 6.97370  12.78927  -15.56447 1.000 23.90105 ? 209 TYR A O   1 
ATOM   1600 C  CB  . TYR A 1 209 ? 10.17324 12.74844  -14.73831 1.000 22.15067 ? 209 TYR A CB  1 
ATOM   1601 C  CG  . TYR A 1 209 ? 11.36481 13.46773  -15.32922 1.000 25.87607 ? 209 TYR A CG  1 
ATOM   1602 C  CD1 . TYR A 1 209 ? 11.38527 13.82772  -16.67316 1.000 25.43782 ? 209 TYR A CD1 1 
ATOM   1603 C  CD2 . TYR A 1 209 ? 12.47036 13.78089  -14.55028 1.000 24.86554 ? 209 TYR A CD2 1 
ATOM   1604 C  CE1 . TYR A 1 209 ? 12.47005 14.48781  -17.22150 1.000 23.66086 ? 209 TYR A CE1 1 
ATOM   1605 C  CE2 . TYR A 1 209 ? 13.56184 14.43929  -15.09110 1.000 25.67842 ? 209 TYR A CE2 1 
ATOM   1606 C  CZ  . TYR A 1 209 ? 13.55584 14.79094  -16.42602 1.000 25.02586 ? 209 TYR A CZ  1 
ATOM   1607 O  OH  . TYR A 1 209 ? 14.63863 15.44671  -16.96525 1.000 22.70370 ? 209 TYR A OH  1 
ATOM   1608 N  N   . ALA A 1 210 ? 7.34746  12.15585  -13.43396 1.000 24.47477 ? 210 ALA A N   1 
ATOM   1609 C  CA  . ALA A 1 210 ? 6.10455  11.39493  -13.36525 1.000 23.00030 ? 210 ALA A CA  1 
ATOM   1610 C  C   . ALA A 1 210 ? 4.89535  12.30155  -13.55029 1.000 26.42480 ? 210 ALA A C   1 
ATOM   1611 O  O   . ALA A 1 210 ? 3.90535  11.91010  -14.18122 1.000 25.95224 ? 210 ALA A O   1 
ATOM   1612 C  CB  . ALA A 1 210 ? 6.01596  10.65100  -12.03249 1.000 25.81656 ? 210 ALA A CB  1 
ATOM   1613 N  N   . ALA A 1 211 ? 4.95079  13.51449  -12.99633 1.000 20.29844 ? 211 ALA A N   1 
ATOM   1614 C  CA  . ALA A 1 211 ? 3.86148  14.46283  -13.19147 1.000 24.55504 ? 211 ALA A CA  1 
ATOM   1615 C  C   . ALA A 1 211 ? 3.68853  14.79212  -14.66937 1.000 27.88173 ? 211 ALA A C   1 
ATOM   1616 O  O   . ALA A 1 211 ? 2.57713  14.72304  -15.20837 1.000 26.32848 ? 211 ALA A O   1 
ATOM   1617 C  CB  . ALA A 1 211 ? 4.11873  15.73119  -12.37969 1.000 24.46262 ? 211 ALA A CB  1 
ATOM   1618 N  N   . VAL A 1 212 ? 4.78537  15.14680  -15.34254 1.000 22.64249 ? 212 VAL A N   1 
ATOM   1619 C  CA  . VAL A 1 212 ? 4.71762  15.47351  -16.76658 1.000 29.03378 ? 212 VAL A CA  1 
ATOM   1620 C  C   . VAL A 1 212 ? 4.14096  14.30817  -17.55814 1.000 26.53032 ? 212 VAL A C   1 
ATOM   1621 O  O   . VAL A 1 212 ? 3.31972  14.49891  -18.46303 1.000 31.74412 ? 212 VAL A O   1 
ATOM   1622 C  CB  . VAL A 1 212 ? 6.10922  15.87141  -17.29087 1.000 25.65096 ? 212 VAL A CB  1 
ATOM   1623 C  CG1 . VAL A 1 212 ? 6.10080  15.94569  -18.81643 1.000 25.34300 ? 212 VAL A CG1 1 
ATOM   1624 C  CG2 . VAL A 1 212 ? 6.53884  17.19179  -16.69069 1.000 22.10332 ? 212 VAL A CG2 1 
ATOM   1625 N  N   . ILE A 1 213 ? 4.56631  13.08579  -17.23697 1.000 26.99227 ? 213 ILE A N   1 
ATOM   1626 C  CA  . ILE A 1 213 ? 4.07581  11.91344  -17.95526 1.000 29.68571 ? 213 ILE A CA  1 
ATOM   1627 C  C   . ILE A 1 213 ? 2.56239  11.80793  -17.83294 1.000 36.04205 ? 213 ILE A C   1 
ATOM   1628 O  O   . ILE A 1 213 ? 1.87160  11.43137  -18.78882 1.000 33.21955 ? 213 ILE A O   1 
ATOM   1629 C  CB  . ILE A 1 213 ? 4.77598  10.64231  -17.43919 1.000 31.78214 ? 213 ILE A CB  1 
ATOM   1630 C  CG1 . ILE A 1 213 ? 6.26227  10.66391  -17.80962 1.000 29.30897 ? 213 ILE A CG1 1 
ATOM   1631 C  CG2 . ILE A 1 213 ? 4.09506  9.39878   -17.98502 1.000 31.29452 ? 213 ILE A CG2 1 
ATOM   1632 C  CD1 . ILE A 1 213 ? 7.04782  9.49021   -17.26353 1.000 30.30186 ? 213 ILE A CD1 1 
ATOM   1633 N  N   . ASN A 1 214 ? 2.02065  12.15802  -16.66590 1.000 34.31854 ? 214 ASN A N   1 
ATOM   1634 C  CA  . ASN A 1 214 ? 0.60793  11.96406  -16.36675 1.000 34.41708 ? 214 ASN A CA  1 
ATOM   1635 C  C   . ASN A 1 214 ? -0.24410 13.20259  -16.62055 1.000 33.88220 ? 214 ASN A C   1 
ATOM   1636 O  O   . ASN A 1 214 ? -1.42276 13.21074  -16.25291 1.000 37.76052 ? 214 ASN A O   1 
ATOM   1637 C  CB  . ASN A 1 214 ? 0.43909  11.50093  -14.91961 1.000 32.06830 ? 214 ASN A CB  1 
ATOM   1638 C  CG  . ASN A 1 214 ? 0.85813  10.05877  -14.72206 1.000 35.35023 ? 214 ASN A CG  1 
ATOM   1639 O  OD1 . ASN A 1 214 ? 0.04669  9.14222   -14.85677 1.000 40.19706 ? 214 ASN A OD1 1 
ATOM   1640 N  ND2 . ASN A 1 214 ? 2.13121  9.84757   -14.40980 1.000 32.22546 ? 214 ASN A ND2 1 
ATOM   1641 N  N   . GLY A 1 215 ? 0.31334  14.24428  -17.23526 1.000 32.23590 ? 215 GLY A N   1 
ATOM   1642 C  CA  . GLY A 1 215 ? -0.46593 15.38414  -17.68049 1.000 34.24039 ? 215 GLY A CA  1 
ATOM   1643 C  C   . GLY A 1 215 ? -0.25196 16.66769  -16.90846 1.000 37.10889 ? 215 GLY A C   1 
ATOM   1644 O  O   . GLY A 1 215 ? -0.71384 17.72215  -17.36576 1.000 37.07507 ? 215 GLY A O   1 
ATOM   1645 N  N   . ASP A 1 216 ? 0.41404  16.62514  -15.75612 1.000 34.16175 ? 216 ASP A N   1 
ATOM   1646 C  CA  . ASP A 1 216 ? 0.70014  17.83727  -14.99264 1.000 34.00469 ? 216 ASP A CA  1 
ATOM   1647 C  C   . ASP A 1 216 ? 1.97656  18.46844  -15.53586 1.000 34.00552 ? 216 ASP A C   1 
ATOM   1648 O  O   . ASP A 1 216 ? 3.07191  17.92359  -15.36029 1.000 32.35689 ? 216 ASP A O   1 
ATOM   1649 C  CB  . ASP A 1 216 ? 0.83446  17.52519  -13.50438 1.000 33.71681 ? 216 ASP A CB  1 
ATOM   1650 C  CG  . ASP A 1 216 ? -0.50658 17.33793  -12.82078 1.000 36.16737 ? 216 ASP A CG  1 
ATOM   1651 O  OD1 . ASP A 1 216 ? -1.53741 17.28512  -13.52454 1.000 42.65341 ? 216 ASP A OD1 1 
ATOM   1652 O  OD2 . ASP A 1 216 ? -0.52983 17.24739  -11.57468 1.000 33.39274 ? 216 ASP A OD2 1 
ATOM   1653 N  N   . ARG A 1 217 ? 1.84008  19.62252  -16.19249 1.000 33.60731 ? 217 ARG A N   1 
ATOM   1654 C  CA  . ARG A 1 217 ? 2.98274  20.26171  -16.83199 1.000 34.44979 ? 217 ARG A CA  1 
ATOM   1655 C  C   . ARG A 1 217 ? 3.02487  21.76810  -16.60467 1.000 31.74134 ? 217 ARG A C   1 
ATOM   1656 O  O   . ARG A 1 217 ? 3.86437  22.44410  -17.21209 1.000 34.32750 ? 217 ARG A O   1 
ATOM   1657 C  CB  . ARG A 1 217 ? 2.98398  19.96738  -18.33909 1.000 35.12004 ? 217 ARG A CB  1 
ATOM   1658 N  N   . TRP A 1 218 ? 2.16096  22.31632  -15.74749 1.000 30.93173 ? 218 TRP A N   1 
ATOM   1659 C  CA  . TRP A 1 218 ? 2.12564  23.76187  -15.55155 1.000 30.87597 ? 218 TRP A CA  1 
ATOM   1660 C  C   . TRP A 1 218 ? 3.43094  24.30589  -14.98272 1.000 33.21774 ? 218 TRP A C   1 
ATOM   1661 O  O   . TRP A 1 218 ? 3.68483  25.51172  -15.08575 1.000 33.76861 ? 218 TRP A O   1 
ATOM   1662 C  CB  . TRP A 1 218 ? 0.96006  24.13813  -14.63475 1.000 33.37610 ? 218 TRP A CB  1 
ATOM   1663 C  CG  . TRP A 1 218 ? 1.06811  23.55598  -13.25358 1.000 32.33124 ? 218 TRP A CG  1 
ATOM   1664 C  CD1 . TRP A 1 218 ? 0.47949  22.41273  -12.79834 1.000 33.07814 ? 218 TRP A CD1 1 
ATOM   1665 C  CD2 . TRP A 1 218 ? 1.81430  24.08924  -12.15282 1.000 30.67451 ? 218 TRP A CD2 1 
ATOM   1666 N  NE1 . TRP A 1 218 ? 0.80933  22.20201  -11.47990 1.000 33.51884 ? 218 TRP A NE1 1 
ATOM   1667 C  CE2 . TRP A 1 218 ? 1.62875  23.21649  -11.06014 1.000 30.51716 ? 218 TRP A CE2 1 
ATOM   1668 C  CE3 . TRP A 1 218 ? 2.61973  25.21900  -11.98393 1.000 32.02770 ? 218 TRP A CE3 1 
ATOM   1669 C  CZ2 . TRP A 1 218 ? 2.21887  23.43792  -9.81936  1.000 31.33766 ? 218 TRP A CZ2 1 
ATOM   1670 C  CZ3 . TRP A 1 218 ? 3.20621  25.43723  -10.74902 1.000 33.70783 ? 218 TRP A CZ3 1 
ATOM   1671 C  CH2 . TRP A 1 218 ? 3.00160  24.55119  -9.68227  1.000 32.49517 ? 218 TRP A CH2 1 
ATOM   1672 N  N   . PHE A 1 219 ? 4.25787  23.45225  -14.38190 1.000 33.24749 ? 219 PHE A N   1 
ATOM   1673 C  CA  . PHE A 1 219 ? 5.50370  23.88187  -13.76216 1.000 33.10675 ? 219 PHE A CA  1 
ATOM   1674 C  C   . PHE A 1 219 ? 6.67015  23.93955  -14.73938 1.000 32.88131 ? 219 PHE A C   1 
ATOM   1675 O  O   . PHE A 1 219 ? 7.74169  24.43329  -14.37027 1.000 32.09841 ? 219 PHE A O   1 
ATOM   1676 C  CB  . PHE A 1 219 ? 5.85879  22.94945  -12.59886 1.000 29.57053 ? 219 PHE A CB  1 
ATOM   1677 C  CG  . PHE A 1 219 ? 5.82598  21.49677  -12.96425 1.000 28.76617 ? 219 PHE A CG  1 
ATOM   1678 C  CD1 . PHE A 1 219 ? 6.92996  20.88774  -13.53798 1.000 29.75940 ? 219 PHE A CD1 1 
ATOM   1679 C  CD2 . PHE A 1 219 ? 4.68538  20.74280  -12.75104 1.000 25.79380 ? 219 PHE A CD2 1 
ATOM   1680 C  CE1 . PHE A 1 219 ? 6.89880  19.55262  -13.88522 1.000 26.96241 ? 219 PHE A CE1 1 
ATOM   1681 C  CE2 . PHE A 1 219 ? 4.64827  19.40816  -13.09583 1.000 28.09666 ? 219 PHE A CE2 1 
ATOM   1682 C  CZ  . PHE A 1 219 ? 5.75687  18.81114  -13.66396 1.000 29.43606 ? 219 PHE A CZ  1 
ATOM   1683 N  N   . LEU A 1 220 ? 6.50016  23.43829  -15.96052 1.000 32.55588 ? 220 LEU A N   1 
ATOM   1684 C  CA  . LEU A 1 220 ? 7.53669  23.58467  -16.97311 1.000 34.27949 ? 220 LEU A CA  1 
ATOM   1685 C  C   . LEU A 1 220 ? 7.63691  25.04569  -17.39056 1.000 33.96123 ? 220 LEU A C   1 
ATOM   1686 O  O   . LEU A 1 220 ? 6.61899  25.70444  -17.62350 1.000 37.20748 ? 220 LEU A O   1 
ATOM   1687 C  CB  . LEU A 1 220 ? 7.23161  22.70333  -18.18250 1.000 34.12700 ? 220 LEU A CB  1 
ATOM   1688 C  CG  . LEU A 1 220 ? 7.19477  21.19394  -17.93757 1.000 35.01104 ? 220 LEU A CG  1 
ATOM   1689 C  CD1 . LEU A 1 220 ? 6.84165  20.44906  -19.21559 1.000 32.97513 ? 220 LEU A CD1 1 
ATOM   1690 C  CD2 . LEU A 1 220 ? 8.52047  20.69634  -17.36956 1.000 28.14580 ? 220 LEU A CD2 1 
ATOM   1691 N  N   . ASN A 1 221 ? 8.86222  25.55860  -17.47542 1.000 34.22313 ? 221 ASN A N   1 
ATOM   1692 C  CA  . ASN A 1 221 ? 9.08898  26.96128  -17.79381 1.000 33.20772 ? 221 ASN A CA  1 
ATOM   1693 C  C   . ASN A 1 221 ? 10.09930 27.07722  -18.93085 1.000 33.39534 ? 221 ASN A C   1 
ATOM   1694 O  O   . ASN A 1 221 ? 10.57077 26.07852  -19.48194 1.000 29.84287 ? 221 ASN A O   1 
ATOM   1695 C  CB  . ASN A 1 221 ? 9.55593  27.74388  -16.55836 1.000 32.61753 ? 221 ASN A CB  1 
ATOM   1696 C  CG  . ASN A 1 221 ? 10.84634 27.20337  -15.96980 1.000 31.84906 ? 221 ASN A CG  1 
ATOM   1697 O  OD1 . ASN A 1 221 ? 11.69323 26.66132  -16.67771 1.000 28.87790 ? 221 ASN A OD1 1 
ATOM   1698 N  ND2 . ASN A 1 221 ? 11.00241 27.35875  -14.66037 1.000 36.68502 ? 221 ASN A ND2 1 
ATOM   1699 N  N   . ARG A 1 222 ? 10.43177 28.32177  -19.27163 1.000 33.05277 ? 222 ARG A N   1 
ATOM   1700 C  CA  . ARG A 1 222 ? 11.32244 28.64754  -20.37801 1.000 34.88473 ? 222 ARG A CA  1 
ATOM   1701 C  C   . ARG A 1 222 ? 12.77998 28.77768  -19.95652 1.000 33.63409 ? 222 ARG A C   1 
ATOM   1702 O  O   . ARG A 1 222 ? 13.58807 29.30010  -20.73043 1.000 33.46409 ? 222 ARG A O   1 
ATOM   1703 C  CB  . ARG A 1 222 ? 10.88022 29.95562  -21.03888 1.000 35.52528 ? 222 ARG A CB  1 
ATOM   1704 C  CG  . ARG A 1 222 ? 9.47494  29.94642  -21.60839 1.000 37.39878 ? 222 ARG A CG  1 
ATOM   1705 C  CD  . ARG A 1 222 ? 9.02920  31.36441  -21.93962 1.000 37.99642 ? 222 ARG A CD  1 
ATOM   1706 N  NE  . ARG A 1 222 ? 7.81682  31.38841  -22.74880 1.000 38.72126 ? 222 ARG A NE  1 
ATOM   1707 C  CZ  . ARG A 1 222 ? 7.80481  31.45201  -24.07304 1.000 43.58852 ? 222 ARG A CZ  1 
ATOM   1708 N  NH1 . ARG A 1 222 ? 8.92730  31.50016  -24.77340 1.000 39.30235 ? 222 ARG A NH1 1 
ATOM   1709 N  NH2 . ARG A 1 222 ? 6.63816  31.46916  -24.71119 1.000 42.70788 ? 222 ARG A NH2 1 
ATOM   1710 N  N   . PHE A 1 223 ? 13.13483 28.32719  -18.76009 1.000 27.91907 ? 223 PHE A N   1 
ATOM   1711 C  CA  . PHE A 1 223 ? 14.46237 28.54608  -18.20838 1.000 28.34171 ? 223 PHE A CA  1 
ATOM   1712 C  C   . PHE A 1 223 ? 15.27669 27.26138  -18.23971 1.000 28.09697 ? 223 PHE A C   1 
ATOM   1713 O  O   . PHE A 1 223 ? 14.76917 26.16988  -18.50828 1.000 30.13475 ? 223 PHE A O   1 
ATOM   1714 C  CB  . PHE A 1 223 ? 14.37585 29.06563  -16.76820 1.000 31.19229 ? 223 PHE A CB  1 
ATOM   1715 C  CG  . PHE A 1 223 ? 13.47088 30.24932  -16.60146 1.000 31.39626 ? 223 PHE A CG  1 
ATOM   1716 C  CD1 . PHE A 1 223 ? 13.32631 31.17978  -17.61596 1.000 32.77789 ? 223 PHE A CD1 1 
ATOM   1717 C  CD2 . PHE A 1 223 ? 12.76311 30.43192  -15.42685 1.000 35.96536 ? 223 PHE A CD2 1 
ATOM   1718 C  CE1 . PHE A 1 223 ? 12.49250 32.26990  -17.46165 1.000 31.96437 ? 223 PHE A CE1 1 
ATOM   1719 C  CE2 . PHE A 1 223 ? 11.92872 31.52012  -15.26737 1.000 39.05068 ? 223 PHE A CE2 1 
ATOM   1720 C  CZ  . PHE A 1 223 ? 11.79402 32.43955  -16.28633 1.000 37.61828 ? 223 PHE A CZ  1 
ATOM   1721 N  N   . THR A 1 224 ? 16.56603 27.41354  -17.95700 1.000 29.14804 ? 224 THR A N   1 
ATOM   1722 C  CA  . THR A 1 224 ? 17.45007 26.29025  -17.69484 1.000 26.85850 ? 224 THR A CA  1 
ATOM   1723 C  C   . THR A 1 224 ? 18.44405 26.72410  -16.62756 1.000 27.89040 ? 224 THR A C   1 
ATOM   1724 O  O   . THR A 1 224 ? 18.43890 27.87330  -16.17241 1.000 28.37142 ? 224 THR A O   1 
ATOM   1725 C  CB  . THR A 1 224 ? 18.15491 25.80884  -18.96939 1.000 31.47077 ? 224 THR A CB  1 
ATOM   1726 O  OG1 . THR A 1 224 ? 18.82782 24.56947  -18.70561 1.000 30.37876 ? 224 THR A OG1 1 
ATOM   1727 C  CG2 . THR A 1 224 ? 19.16356 26.84341  -19.45215 1.000 27.79598 ? 224 THR A CG2 1 
ATOM   1728 N  N   . THR A 1 225 ? 19.29677 25.79663  -16.21181 1.000 28.40574 ? 225 THR A N   1 
ATOM   1729 C  CA  . THR A 1 225 ? 20.24388 26.07676  -15.14528 1.000 28.90398 ? 225 THR A CA  1 
ATOM   1730 C  C   . THR A 1 225 ? 21.46668 25.19073  -15.33193 1.000 27.40613 ? 225 THR A C   1 
ATOM   1731 O  O   . THR A 1 225 ? 21.55155 24.40020  -16.27601 1.000 28.05379 ? 225 THR A O   1 
ATOM   1732 C  CB  . THR A 1 225 ? 19.60300 25.86343  -13.76899 1.000 27.59241 ? 225 THR A CB  1 
ATOM   1733 O  OG1 . THR A 1 225 ? 20.50995 26.29267  -12.74624 1.000 32.97028 ? 225 THR A OG1 1 
ATOM   1734 C  CG2 . THR A 1 225 ? 19.27226 24.39286  -13.55836 1.000 26.46791 ? 225 THR A CG2 1 
ATOM   1735 N  N   . THR A 1 226 ? 22.42470 25.34272  -14.42657 1.000 30.00256 ? 226 THR A N   1 
ATOM   1736 C  CA  . THR A 1 226 ? 23.60840 24.50365  -14.37933 1.000 27.88759 ? 226 THR A CA  1 
ATOM   1737 C  C   . THR A 1 226 ? 23.58593 23.67440  -13.10363 1.000 28.28969 ? 226 THR A C   1 
ATOM   1738 O  O   . THR A 1 226 ? 22.90896 24.01292  -12.13031 1.000 27.24059 ? 226 THR A O   1 
ATOM   1739 C  CB  . THR A 1 226 ? 24.89009 25.34289  -14.43072 1.000 27.45290 ? 226 THR A CB  1 
ATOM   1740 O  OG1 . THR A 1 226 ? 25.06301 26.02424  -13.18388 1.000 28.16049 ? 226 THR A OG1 1 
ATOM   1741 C  CG2 . THR A 1 226 ? 24.81260 26.36844  -15.54933 1.000 29.98857 ? 226 THR A CG2 1 
ATOM   1742 N  N   . LEU A 1 227 ? 24.33653 22.57201  -13.12229 1.000 27.70084 ? 227 LEU A N   1 
ATOM   1743 C  CA  . LEU A 1 227 ? 24.45732 21.75169  -11.92345 1.000 28.14584 ? 227 LEU A CA  1 
ATOM   1744 C  C   . LEU A 1 227 ? 24.94398 22.58646  -10.74450 1.000 28.54906 ? 227 LEU A C   1 
ATOM   1745 O  O   . LEU A 1 227 ? 24.39485 22.49952  -9.63996  1.000 28.91978 ? 227 LEU A O   1 
ATOM   1746 C  CB  . LEU A 1 227 ? 25.39869 20.57572  -12.19583 1.000 32.13267 ? 227 LEU A CB  1 
ATOM   1747 C  CG  . LEU A 1 227 ? 25.27824 19.30571  -11.35119 1.000 33.69689 ? 227 LEU A CG  1 
ATOM   1748 C  CD1 . LEU A 1 227 ? 23.86845 18.73703  -11.42276 1.000 33.10793 ? 227 LEU A CD1 1 
ATOM   1749 C  CD2 . LEU A 1 227 ? 26.29780 18.26856  -11.81076 1.000 26.49388 ? 227 LEU A CD2 1 
ATOM   1750 N  N   . ASN A 1 228 ? 25.95571 23.42749  -10.96729 1.000 27.16570 ? 228 ASN A N   1 
ATOM   1751 C  CA  . ASN A 1 228 ? 26.47120 24.26230  -9.88746  1.000 31.14359 ? 228 ASN A CA  1 
ATOM   1752 C  C   . ASN A 1 228 ? 25.43426 25.28339  -9.43154  1.000 28.55566 ? 228 ASN A C   1 
ATOM   1753 O  O   . ASN A 1 228 ? 25.21211 25.46250  -8.22847  1.000 29.59126 ? 228 ASN A O   1 
ATOM   1754 C  CB  . ASN A 1 228 ? 27.75805 24.95747  -10.33208 1.000 32.37513 ? 228 ASN A CB  1 
ATOM   1755 C  CG  . ASN A 1 228 ? 28.86413 23.97514  -10.66156 1.000 32.71737 ? 228 ASN A CG  1 
ATOM   1756 O  OD1 . ASN A 1 228 ? 29.48495 24.05302  -11.72257 1.000 35.62642 ? 228 ASN A OD1 1 
ATOM   1757 N  ND2 . ASN A 1 228 ? 29.10889 23.03496  -9.75512  1.000 32.70936 ? 228 ASN A ND2 1 
ATOM   1758 N  N   . ASP A 1 229 ? 24.79225 25.97064  -10.37723 1.000 29.26141 ? 229 ASP A N   1 
ATOM   1759 C  CA  . ASP A 1 229 ? 23.80650 26.97839  -9.99994  1.000 32.04448 ? 229 ASP A CA  1 
ATOM   1760 C  C   . ASP A 1 229 ? 22.65719 26.35827  -9.21446  1.000 29.78069 ? 229 ASP A C   1 
ATOM   1761 O  O   . ASP A 1 229 ? 22.23610 26.89992  -8.18514  1.000 30.44698 ? 229 ASP A O   1 
ATOM   1762 C  CB  . ASP A 1 229 ? 23.28400 27.69869  -11.24354 1.000 28.66275 ? 229 ASP A CB  1 
ATOM   1763 C  CG  . ASP A 1 229 ? 22.18403 28.69483  -10.92246 1.000 31.44672 ? 229 ASP A CG  1 
ATOM   1764 O  OD1 . ASP A 1 229 ? 22.49595 29.77585  -10.37707 1.000 34.15845 ? 229 ASP A OD1 1 
ATOM   1765 O  OD2 . ASP A 1 229 ? 21.00442 28.39512  -11.21509 1.000 31.15254 ? 229 ASP A OD2 1 
ATOM   1766 N  N   . PHE A 1 230 ? 22.13749 25.21969  -9.68111  1.000 28.91570 ? 230 PHE A N   1 
ATOM   1767 C  CA  . PHE A 1 230 ? 21.04240 24.57249  -8.96584  1.000 30.75342 ? 230 PHE A CA  1 
ATOM   1768 C  C   . PHE A 1 230 ? 21.46451 24.17072  -7.55971  1.000 28.14459 ? 230 PHE A C   1 
ATOM   1769 O  O   . PHE A 1 230 ? 20.68691 24.30420  -6.60680  1.000 31.20566 ? 230 PHE A O   1 
ATOM   1770 C  CB  . PHE A 1 230 ? 20.54668 23.35195  -9.73746  1.000 27.13471 ? 230 PHE A CB  1 
ATOM   1771 C  CG  . PHE A 1 230 ? 19.53575 22.53900  -8.98324  1.000 26.92008 ? 230 PHE A CG  1 
ATOM   1772 C  CD1 . PHE A 1 230 ? 18.19249 22.87632  -9.01973  1.000 28.35997 ? 230 PHE A CD1 1 
ATOM   1773 C  CD2 . PHE A 1 230 ? 19.92978 21.44839  -8.22008  1.000 30.60339 ? 230 PHE A CD2 1 
ATOM   1774 C  CE1 . PHE A 1 230 ? 17.25950 22.13678  -8.31948  1.000 29.37041 ? 230 PHE A CE1 1 
ATOM   1775 C  CE2 . PHE A 1 230 ? 19.00113 20.70488  -7.51552  1.000 28.82946 ? 230 PHE A CE2 1 
ATOM   1776 C  CZ  . PHE A 1 230 ? 17.66254 21.05000  -7.56484  1.000 27.56744 ? 230 PHE A CZ  1 
ATOM   1777 N  N   . ASN A 1 231 ? 22.69357 23.67408  -7.40898  1.000 26.70459 ? 231 ASN A N   1 
ATOM   1778 C  CA  . ASN A 1 231 ? 23.15820 23.26020  -6.09049  1.000 29.95562 ? 231 ASN A CA  1 
ATOM   1779 C  C   . ASN A 1 231 ? 23.23780 24.43755  -5.12881  1.000 29.41302 ? 231 ASN A C   1 
ATOM   1780 O  O   . ASN A 1 231 ? 23.07735 24.25642  -3.91749  1.000 27.08868 ? 231 ASN A O   1 
ATOM   1781 C  CB  . ASN A 1 231 ? 24.50951 22.55372  -6.20749  1.000 30.02068 ? 231 ASN A CB  1 
ATOM   1782 C  CG  . ASN A 1 231 ? 24.36659 21.10828  -6.64502  1.000 28.25348 ? 231 ASN A CG  1 
ATOM   1783 O  OD1 . ASN A 1 231 ? 23.29163 20.52134  -6.52540  1.000 31.06491 ? 231 ASN A OD1 1 
ATOM   1784 N  ND2 . ASN A 1 231 ? 25.44836 20.52477  -7.14335  1.000 30.81184 ? 231 ASN A ND2 1 
ATOM   1785 N  N   . LEU A 1 232 ? 23.47420 25.64768  -5.64261  1.000 29.42224 ? 232 LEU A N   1 
ATOM   1786 C  CA  . LEU A 1 232 ? 23.36650 26.83374  -4.79921  1.000 29.68898 ? 232 LEU A CA  1 
ATOM   1787 C  C   . LEU A 1 232 ? 21.96969 26.95502  -4.20813  1.000 31.53518 ? 232 LEU A C   1 
ATOM   1788 O  O   . LEU A 1 232 ? 21.81208 27.25966  -3.01942  1.000 31.03613 ? 232 LEU A O   1 
ATOM   1789 C  CB  . LEU A 1 232 ? 23.71266 28.09002  -5.59902  1.000 29.75567 ? 232 LEU A CB  1 
ATOM   1790 C  CG  . LEU A 1 232 ? 25.19496 28.35682  -5.85891  1.000 36.53955 ? 232 LEU A CG  1 
ATOM   1791 C  CD1 . LEU A 1 232 ? 25.38003 29.72642  -6.50147  1.000 38.53357 ? 232 LEU A CD1 1 
ATOM   1792 C  CD2 . LEU A 1 232 ? 25.99128 28.24974  -4.56579  1.000 32.81720 ? 232 LEU A CD2 1 
ATOM   1793 N  N   . VAL A 1 233 ? 20.94206 26.72076  -5.02648  1.000 28.34065 ? 233 VAL A N   1 
ATOM   1794 C  CA  . VAL A 1 233 ? 19.56918 26.79180  -4.53927  1.000 28.27265 ? 233 VAL A CA  1 
ATOM   1795 C  C   . VAL A 1 233 ? 19.25029 25.58746  -3.66300  1.000 29.04520 ? 233 VAL A C   1 
ATOM   1796 O  O   . VAL A 1 233 ? 18.55698 25.70870  -2.64554  1.000 28.00674 ? 233 VAL A O   1 
ATOM   1797 C  CB  . VAL A 1 233 ? 18.59145 26.90670  -5.72289  1.000 28.26571 ? 233 VAL A CB  1 
ATOM   1798 C  CG1 . VAL A 1 233 ? 17.15748 26.93593  -5.22389  1.000 30.97493 ? 233 VAL A CG1 1 
ATOM   1799 C  CG2 . VAL A 1 233 ? 18.90299 28.14702  -6.55023  1.000 30.16501 ? 233 VAL A CG2 1 
ATOM   1800 N  N   . ALA A 1 234 ? 19.74281 24.40642  -4.04326  1.000 28.23541 ? 234 ALA A N   1 
ATOM   1801 C  CA  . ALA A 1 234 ? 19.51779 23.21592  -3.23032  1.000 29.54214 ? 234 ALA A CA  1 
ATOM   1802 C  C   . ALA A 1 234 ? 19.97713 23.44176  -1.79605  1.000 28.89716 ? 234 ALA A C   1 
ATOM   1803 O  O   . ALA A 1 234 ? 19.23339 23.18379  -0.84307  1.000 28.09188 ? 234 ALA A O   1 
ATOM   1804 C  CB  . ALA A 1 234 ? 20.23816 22.01500  -3.84490  1.000 27.67362 ? 234 ALA A CB  1 
ATOM   1805 N  N   . MET A 1 235 ? 21.20659 23.93765  -1.62696  1.000 31.28822 ? 235 MET A N   1 
ATOM   1806 C  CA  . MET A 1 235 ? 21.73112 24.18153  -0.28726  1.000 31.93000 ? 235 MET A CA  1 
ATOM   1807 C  C   . MET A 1 235 ? 20.83647 25.13720  0.49103   1.000 31.58076 ? 235 MET A C   1 
ATOM   1808 O  O   . MET A 1 235 ? 20.58205 24.93081  1.68426   1.000 29.90716 ? 235 MET A O   1 
ATOM   1809 C  CB  . MET A 1 235 ? 23.15433 24.73186  -0.37575  1.000 32.87070 ? 235 MET A CB  1 
ATOM   1810 N  N   . LYS A 1 236 ? 20.34338 26.18753  -0.16953  1.000 32.31361 ? 236 LYS A N   1 
ATOM   1811 C  CA  . LYS A 1 236 ? 19.51607 27.17102  0.52262   1.000 29.93721 ? 236 LYS A CA  1 
ATOM   1812 C  C   . LYS A 1 236 ? 18.26531 26.53148  1.11216   1.000 29.98753 ? 236 LYS A C   1 
ATOM   1813 O  O   . LYS A 1 236 ? 17.85445 26.87235  2.22557   1.000 28.77414 ? 236 LYS A O   1 
ATOM   1814 C  CB  . LYS A 1 236 ? 19.13809 28.30631  -0.43006  1.000 29.46474 ? 236 LYS A CB  1 
ATOM   1815 N  N   . TYR A 1 237 ? 17.64689 25.59989  0.38429   1.000 30.06127 ? 237 TYR A N   1 
ATOM   1816 C  CA  . TYR A 1 237 ? 16.37456 25.01341  0.78555   1.000 29.78037 ? 237 TYR A CA  1 
ATOM   1817 C  C   . TYR A 1 237 ? 16.52994 23.62089  1.39123   1.000 25.89253 ? 237 TYR A C   1 
ATOM   1818 O  O   . TYR A 1 237 ? 15.55007 22.87375  1.47889   1.000 27.77283 ? 237 TYR A O   1 
ATOM   1819 C  CB  . TYR A 1 237 ? 15.41639 24.99181  -0.40551  1.000 25.17253 ? 237 TYR A CB  1 
ATOM   1820 C  CG  . TYR A 1 237 ? 14.95855 26.38029  -0.79777  1.000 29.74872 ? 237 TYR A CG  1 
ATOM   1821 C  CD1 . TYR A 1 237 ? 13.83171 26.94728  -0.21778  1.000 32.75450 ? 237 TYR A CD1 1 
ATOM   1822 C  CD2 . TYR A 1 237 ? 15.66682 27.13298  -1.72668  1.000 29.42477 ? 237 TYR A CD2 1 
ATOM   1823 C  CE1 . TYR A 1 237 ? 13.41127 28.21738  -0.56073  1.000 34.63363 ? 237 TYR A CE1 1 
ATOM   1824 C  CE2 . TYR A 1 237 ? 15.25515 28.40664  -2.07655  1.000 31.12150 ? 237 TYR A CE2 1 
ATOM   1825 C  CZ  . TYR A 1 237 ? 14.12556 28.94357  -1.48900  1.000 32.92161 ? 237 TYR A CZ  1 
ATOM   1826 O  OH  . TYR A 1 237 ? 13.70397 30.20985  -1.82853  1.000 34.12134 ? 237 TYR A OH  1 
ATOM   1827 N  N   . ASN A 1 238 ? 17.74080 23.26650  1.81537   1.000 27.15508 ? 238 ASN A N   1 
ATOM   1828 C  CA  A ASN A 1 238 ? 18.00615 21.99927  2.49688   0.500 25.83693 ? 238 ASN A CA  1 
ATOM   1829 C  CA  B ASN A 1 238 ? 18.00282 21.99939  2.49709   0.500 26.06887 ? 238 ASN A CA  1 
ATOM   1830 C  C   . ASN A 1 238 ? 17.65748 20.80299  1.61117   1.000 25.96148 ? 238 ASN A C   1 
ATOM   1831 O  O   . ASN A 1 238 ? 17.01581 19.84275  2.04297   1.000 24.86580 ? 238 ASN A O   1 
ATOM   1832 C  CB  A ASN A 1 238 ? 17.26428 21.92290  3.83266   0.500 25.86183 ? 238 ASN A CB  1 
ATOM   1833 C  CB  B ASN A 1 238 ? 17.25414 21.93182  3.82921   0.500 26.08742 ? 238 ASN A CB  1 
ATOM   1834 C  CG  A ASN A 1 238 ? 17.75022 20.77627  4.69518   0.500 26.61586 ? 238 ASN A CG  1 
ATOM   1835 C  CG  B ASN A 1 238 ? 17.77902 22.93082  4.83887   0.500 27.95143 ? 238 ASN A CG  1 
ATOM   1836 O  OD1 A ASN A 1 238 ? 18.91749 20.39480  4.62862   0.500 26.40711 ? 238 ASN A OD1 1 
ATOM   1837 O  OD1 B ASN A 1 238 ? 18.91007 23.40351  4.72848   0.500 29.99753 ? 238 ASN A OD1 1 
ATOM   1838 N  ND2 A ASN A 1 238 ? 16.85632 20.21154  5.49855   0.500 26.73982 ? 238 ASN A ND2 1 
ATOM   1839 N  ND2 B ASN A 1 238 ? 16.96179 23.25422  5.83338   0.500 30.52999 ? 238 ASN A ND2 1 
ATOM   1840 N  N   . TYR A 1 239 ? 18.09350 20.86773  0.35898   1.000 23.59369 ? 239 TYR A N   1 
ATOM   1841 C  CA  . TYR A 1 239 ? 17.98424 19.75394  -0.56856  1.000 23.06839 ? 239 TYR A CA  1 
ATOM   1842 C  C   . TYR A 1 239 ? 19.34539 19.08993  -0.69763  1.000 24.14800 ? 239 TYR A C   1 
ATOM   1843 O  O   . TYR A 1 239 ? 20.37851 19.76319  -0.65155  1.000 25.25127 ? 239 TYR A O   1 
ATOM   1844 C  CB  . TYR A 1 239 ? 17.50566 20.22070  -1.94479  1.000 21.44377 ? 239 TYR A CB  1 
ATOM   1845 C  CG  . TYR A 1 239 ? 16.00616 20.20451  -2.12661  1.000 21.83843 ? 239 TYR A CG  1 
ATOM   1846 C  CD1 . TYR A 1 239 ? 15.17288 20.86293  -1.23624  1.000 24.94458 ? 239 TYR A CD1 1 
ATOM   1847 C  CD2 . TYR A 1 239 ? 15.42501 19.53935  -3.19997  1.000 24.70450 ? 239 TYR A CD2 1 
ATOM   1848 C  CE1 . TYR A 1 239 ? 13.79836 20.85266  -1.40269  1.000 26.63442 ? 239 TYR A CE1 1 
ATOM   1849 C  CE2 . TYR A 1 239 ? 14.05298 19.52495  -3.37825  1.000 23.00563 ? 239 TYR A CE2 1 
ATOM   1850 C  CZ  . TYR A 1 239 ? 13.24396 20.18276  -2.47483  1.000 23.61174 ? 239 TYR A CZ  1 
ATOM   1851 O  OH  . TYR A 1 239 ? 11.87694 20.17156  -2.64378  1.000 24.98878 ? 239 TYR A OH  1 
ATOM   1852 N  N   . GLU A 1 240 ? 19.34564 17.77181  -0.85465  1.000 24.13559 ? 240 GLU A N   1 
ATOM   1853 C  CA  . GLU A 1 240 ? 20.59735 17.07968  -1.11561  1.000 28.10593 ? 240 GLU A CA  1 
ATOM   1854 C  C   . GLU A 1 240 ? 21.22587 17.62659  -2.39315  1.000 27.03680 ? 240 GLU A C   1 
ATOM   1855 O  O   . GLU A 1 240 ? 20.51393 17.90176  -3.36736  1.000 25.74047 ? 240 GLU A O   1 
ATOM   1856 C  CB  . GLU A 1 240 ? 20.37752 15.57362  -1.25544  1.000 29.76046 ? 240 GLU A CB  1 
ATOM   1857 C  CG  . GLU A 1 240 ? 19.92580 14.88898  0.01494   1.000 37.17876 ? 240 GLU A CG  1 
ATOM   1858 C  CD  . GLU A 1 240 ? 20.22730 13.40554  -0.00169  1.000 45.86997 ? 240 GLU A CD  1 
ATOM   1859 O  OE1 . GLU A 1 240 ? 21.20961 13.00853  -0.66496  1.000 54.91180 ? 240 GLU A OE1 1 
ATOM   1860 O  OE2 . GLU A 1 240 ? 19.48151 12.63689  0.64073   1.000 42.57815 ? 240 GLU A OE2 1 
ATOM   1861 N  N   . PRO A 1 241 ? 22.54311 17.80802  -2.42676  1.000 24.42010 ? 241 PRO A N   1 
ATOM   1862 C  CA  . PRO A 1 241 ? 23.18273 18.26821  -3.66294  1.000 28.30971 ? 241 PRO A CA  1 
ATOM   1863 C  C   . PRO A 1 241 ? 22.97557 17.26172  -4.78426  1.000 27.18372 ? 241 PRO A C   1 
ATOM   1864 O  O   . PRO A 1 241 ? 22.94716 16.04898  -4.56013  1.000 28.48481 ? 241 PRO A O   1 
ATOM   1865 C  CB  . PRO A 1 241 ? 24.66172 18.38972  -3.27561  1.000 26.15905 ? 241 PRO A CB  1 
ATOM   1866 C  CG  . PRO A 1 241 ? 24.64638 18.55767  -1.78427  1.000 28.05707 ? 241 PRO A CG  1 
ATOM   1867 C  CD  . PRO A 1 241 ? 23.49737 17.71677  -1.30899  1.000 28.77992 ? 241 PRO A CD  1 
ATOM   1868 N  N   . LEU A 1 242 ? 22.82071 17.77785  -6.00015  1.000 29.10933 ? 242 LEU A N   1 
ATOM   1869 C  CA  . LEU A 1 242 ? 22.65781 16.93680  -7.17713  1.000 26.33404 ? 242 LEU A CA  1 
ATOM   1870 C  C   . LEU A 1 242 ? 24.02236 16.65298  -7.79127  1.000 27.26616 ? 242 LEU A C   1 
ATOM   1871 O  O   . LEU A 1 242 ? 24.83316 17.56877  -7.96828  1.000 27.84957 ? 242 LEU A O   1 
ATOM   1872 C  CB  . LEU A 1 242 ? 21.74201 17.60736  -8.20127  1.000 24.74792 ? 242 LEU A CB  1 
ATOM   1873 C  CG  . LEU A 1 242 ? 21.23876 16.70396  -9.32623  1.000 27.65035 ? 242 LEU A CG  1 
ATOM   1874 C  CD1 . LEU A 1 242 ? 20.36208 15.59900  -8.76194  1.000 26.50447 ? 242 LEU A CD1 1 
ATOM   1875 C  CD2 . LEU A 1 242 ? 20.48247 17.51593  -10.36029 1.000 27.89800 ? 242 LEU A CD2 1 
ATOM   1876 N  N   . THR A 1 243 ? 24.27369 15.38612  -8.10567  1.000 26.28579 ? 243 THR A N   1 
ATOM   1877 C  CA  . THR A 1 243 ? 25.53230 14.95186  -8.69217  1.000 28.72866 ? 243 THR A CA  1 
ATOM   1878 C  C   . THR A 1 243 ? 25.29305 14.43028  -10.10289 1.000 27.82524 ? 243 THR A C   1 
ATOM   1879 O  O   . THR A 1 243 ? 24.15454 14.29037  -10.55713 1.000 21.57691 ? 243 THR A O   1 
ATOM   1880 C  CB  . THR A 1 243 ? 26.19898 13.86475  -7.84112  1.000 28.15368 ? 243 THR A CB  1 
ATOM   1881 O  OG1 . THR A 1 243 ? 25.43877 12.65322  -7.93587  1.000 26.33998 ? 243 THR A OG1 1 
ATOM   1882 C  CG2 . THR A 1 243 ? 26.27288 14.29968  -6.38553  1.000 27.04848 ? 243 THR A CG2 1 
ATOM   1883 N  N   . GLN A 1 244 ? 26.39606 14.14258  -10.79901 1.000 31.60645 ? 244 GLN A N   1 
ATOM   1884 C  CA  . GLN A 1 244 ? 26.29520 13.57079  -12.13840 1.000 26.21510 ? 244 GLN A CA  1 
ATOM   1885 C  C   . GLN A 1 244 ? 25.71934 12.15959  -12.09217 1.000 26.40656 ? 244 GLN A C   1 
ATOM   1886 O  O   . GLN A 1 244 ? 24.99018 11.75152  -13.00292 1.000 26.56501 ? 244 GLN A O   1 
ATOM   1887 C  CB  . GLN A 1 244 ? 27.66645 13.57399  -12.81459 1.000 30.85063 ? 244 GLN A CB  1 
ATOM   1888 C  CG  . GLN A 1 244 ? 27.65845 13.06309  -14.24855 1.000 28.01358 ? 244 GLN A CG  1 
ATOM   1889 C  CD  . GLN A 1 244 ? 26.83712 13.93665  -15.17752 1.000 31.67149 ? 244 GLN A CD  1 
ATOM   1890 O  OE1 . GLN A 1 244 ? 26.92111 15.16500  -15.13095 1.000 31.97326 ? 244 GLN A OE1 1 
ATOM   1891 N  NE2 . GLN A 1 244 ? 26.03195 13.30502  -16.02691 1.000 25.55342 ? 244 GLN A NE2 1 
ATOM   1892 N  N   . ASP A 1 245 ? 26.04343 11.39388  -11.04669 1.000 28.93282 ? 245 ASP A N   1 
ATOM   1893 C  CA  . ASP A 1 245 ? 25.41850 10.08564  -10.87761 1.000 26.66977 ? 245 ASP A CA  1 
ATOM   1894 C  C   . ASP A 1 245 ? 23.90226 10.21124  -10.81343 1.000 26.17101 ? 245 ASP A C   1 
ATOM   1895 O  O   . ASP A 1 245 ? 23.17711 9.35978   -11.34019 1.000 29.33638 ? 245 ASP A O   1 
ATOM   1896 C  CB  . ASP A 1 245 ? 25.94794 9.39954   -9.61765  1.000 32.08723 ? 245 ASP A CB  1 
ATOM   1897 C  CG  . ASP A 1 245 ? 27.39222 8.95689   -9.75197  1.000 33.07553 ? 245 ASP A CG  1 
ATOM   1898 O  OD1 . ASP A 1 245 ? 27.89316 8.88731   -10.89356 1.000 38.33813 ? 245 ASP A OD1 1 
ATOM   1899 O  OD2 . ASP A 1 245 ? 28.02101 8.66332   -8.71317  1.000 35.23798 ? 245 ASP A OD2 1 
ATOM   1900 N  N   . HIS A 1 246 ? 23.40485 11.26681  -10.16511 1.000 26.94758 ? 246 HIS A N   1 
ATOM   1901 C  CA  . HIS A 1 246 ? 21.96727 11.52009  -10.14698 1.000 26.42065 ? 246 HIS A CA  1 
ATOM   1902 C  C   . HIS A 1 246 ? 21.44898 11.83624  -11.54497 1.000 23.80429 ? 246 HIS A C   1 
ATOM   1903 O  O   . HIS A 1 246 ? 20.40324 11.32616  -11.96216 1.000 25.74480 ? 246 HIS A O   1 
ATOM   1904 C  CB  . HIS A 1 246 ? 21.64821 12.66828  -9.18927  1.000 23.52240 ? 246 HIS A CB  1 
ATOM   1905 C  CG  . HIS A 1 246 ? 21.90303 12.34797  -7.75051  1.000 26.88879 ? 246 HIS A CG  1 
ATOM   1906 N  ND1 . HIS A 1 246 ? 22.14229 13.32184  -6.80445  1.000 27.53198 ? 246 HIS A ND1 1 
ATOM   1907 C  CD2 . HIS A 1 246 ? 21.94708 11.16502  -7.09259  1.000 28.85252 ? 246 HIS A CD2 1 
ATOM   1908 C  CE1 . HIS A 1 246 ? 22.32910 12.75216  -5.62695  1.000 28.89063 ? 246 HIS A CE1 1 
ATOM   1909 N  NE2 . HIS A 1 246 ? 22.21257 11.44454  -5.77360  1.000 30.10277 ? 246 HIS A NE2 1 
ATOM   1910 N  N   . VAL A 1 247 ? 22.15580 12.70120  -12.27699 1.000 23.32872 ? 247 VAL A N   1 
ATOM   1911 C  CA  . VAL A 1 247 ? 21.73259 13.03150  -13.63599 1.000 23.45987 ? 247 VAL A CA  1 
ATOM   1912 C  C   . VAL A 1 247 ? 21.67956 11.77334  -14.49195 1.000 24.27871 ? 247 VAL A C   1 
ATOM   1913 O  O   . VAL A 1 247 ? 20.75056 11.58109  -15.28662 1.000 24.96624 ? 247 VAL A O   1 
ATOM   1914 C  CB  . VAL A 1 247 ? 22.66216 14.09545  -14.25122 1.000 21.88480 ? 247 VAL A CB  1 
ATOM   1915 C  CG1 . VAL A 1 247 ? 22.32655 14.30461  -15.72079 1.000 20.62543 ? 247 VAL A CG1 1 
ATOM   1916 C  CG2 . VAL A 1 247 ? 22.54799 15.40615  -13.48942 1.000 22.31823 ? 247 VAL A CG2 1 
ATOM   1917 N  N   . ASP A 1 248 ? 22.67162 10.89463  -14.33869 1.000 22.39818 ? 248 ASP A N   1 
ATOM   1918 C  CA  . ASP A 1 248 ? 22.69074 9.65835   -15.11221 1.000 26.10485 ? 248 ASP A CA  1 
ATOM   1919 C  C   . ASP A 1 248 ? 21.48243 8.78687   -14.79239 1.000 27.99754 ? 248 ASP A C   1 
ATOM   1920 O  O   . ASP A 1 248 ? 20.85027 8.23335   -15.69981 1.000 28.95583 ? 248 ASP A O   1 
ATOM   1921 C  CB  . ASP A 1 248 ? 23.99149 8.90138   -14.84687 1.000 27.84321 ? 248 ASP A CB  1 
ATOM   1922 C  CG  . ASP A 1 248 ? 25.20868 9.62812   -15.38943 1.000 29.66121 ? 248 ASP A CG  1 
ATOM   1923 O  OD1 . ASP A 1 248 ? 25.02516 10.57914  -16.17583 1.000 23.87010 ? 248 ASP A OD1 1 
ATOM   1924 O  OD2 . ASP A 1 248 ? 26.34529 9.25116   -15.02827 1.000 32.46090 ? 248 ASP A OD2 1 
ATOM   1925 N  N   . ILE A 1 249 ? 21.14129 8.65763   -13.50677 1.000 24.87638 ? 249 ILE A N   1 
ATOM   1926 C  CA  . ILE A 1 249 ? 20.00666 7.82383   -13.11650 1.000 25.76723 ? 249 ILE A CA  1 
ATOM   1927 C  C   . ILE A 1 249 ? 18.70730 8.36638   -13.69078 1.000 23.31071 ? 249 ILE A C   1 
ATOM   1928 O  O   . ILE A 1 249 ? 17.77007 7.60357   -13.95821 1.000 25.03799 ? 249 ILE A O   1 
ATOM   1929 C  CB  . ILE A 1 249 ? 19.93224 7.70437   -11.58060 1.000 28.28422 ? 249 ILE A CB  1 
ATOM   1930 C  CG1 . ILE A 1 249 ? 21.18045 7.00368   -11.03748 1.000 28.91908 ? 249 ILE A CG1 1 
ATOM   1931 C  CG2 . ILE A 1 249 ? 18.67003 6.96284   -11.16754 1.000 29.39551 ? 249 ILE A CG2 1 
ATOM   1932 C  CD1 . ILE A 1 249 ? 21.20927 6.87965   -9.52174  1.000 34.23079 ? 249 ILE A CD1 1 
ATOM   1933 N  N   . LEU A 1 250 ? 18.61944 9.67942   -13.88274 1.000 22.30574 ? 250 LEU A N   1 
ATOM   1934 C  CA  . LEU A 1 250 ? 17.42569 10.28999  -14.45501 1.000 24.83553 ? 250 LEU A CA  1 
ATOM   1935 C  C   . LEU A 1 250 ? 17.39817 10.22925  -15.97845 1.000 23.55506 ? 250 LEU A C   1 
ATOM   1936 O  O   . LEU A 1 250 ? 16.43450 10.71212  -16.58168 1.000 24.47396 ? 250 LEU A O   1 
ATOM   1937 C  CB  . LEU A 1 250 ? 17.31070 11.74615  -13.99180 1.000 22.21623 ? 250 LEU A CB  1 
ATOM   1938 C  CG  . LEU A 1 250 ? 17.03048 11.96570  -12.50275 1.000 26.36983 ? 250 LEU A CG  1 
ATOM   1939 C  CD1 . LEU A 1 250 ? 17.20511 13.43191  -12.12410 1.000 23.64559 ? 250 LEU A CD1 1 
ATOM   1940 C  CD2 . LEU A 1 250 ? 15.63121 11.49068  -12.14578 1.000 22.28421 ? 250 LEU A CD2 1 
ATOM   1941 N  N   . GLY A 1 251 ? 18.41826 9.64663   -16.60465 1.000 23.19348 ? 251 GLY A N   1 
ATOM   1942 C  CA  . GLY A 1 251 ? 18.52513 9.59411   -18.04486 1.000 26.31062 ? 251 GLY A CA  1 
ATOM   1943 C  C   . GLY A 1 251 ? 17.31206 8.99984   -18.73497 1.000 26.86981 ? 251 GLY A C   1 
ATOM   1944 O  O   . GLY A 1 251 ? 16.77049 9.57657   -19.68270 1.000 26.61793 ? 251 GLY A O   1 
ATOM   1945 N  N   . PRO A 1 252 ? 16.87028 7.82120   -18.28517 1.000 26.64972 ? 252 PRO A N   1 
ATOM   1946 C  CA  . PRO A 1 252 ? 15.67458 7.21170   -18.89908 1.000 27.56893 ? 252 PRO A CA  1 
ATOM   1947 C  C   . PRO A 1 252 ? 14.44967 8.11403   -18.88464 1.000 29.69470 ? 252 PRO A C   1 
ATOM   1948 O  O   . PRO A 1 252 ? 13.80474 8.29328   -19.92532 1.000 30.19429 ? 252 PRO A O   1 
ATOM   1949 C  CB  . PRO A 1 252 ? 15.47113 5.94509   -18.05724 1.000 29.41137 ? 252 PRO A CB  1 
ATOM   1950 C  CG  . PRO A 1 252 ? 16.83935 5.61175   -17.55893 1.000 30.21685 ? 252 PRO A CG  1 
ATOM   1951 C  CD  . PRO A 1 252 ? 17.49602 6.93208   -17.29102 1.000 28.98151 ? 252 PRO A CD  1 
ATOM   1952 N  N   . LEU A 1 253 ? 14.10376 8.68700   -17.72804 1.000 25.20767 ? 253 LEU A N   1 
ATOM   1953 C  CA  . LEU A 1 253 ? 12.94854 9.57829   -17.66646 1.000 23.19524 ? 253 LEU A CA  1 
ATOM   1954 C  C   . LEU A 1 253 ? 13.15333 10.80069  -18.54967 1.000 29.35994 ? 253 LEU A C   1 
ATOM   1955 O  O   . LEU A 1 253 ? 12.20834 11.28676  -19.18317 1.000 28.39605 ? 253 LEU A O   1 
ATOM   1956 C  CB  . LEU A 1 253 ? 12.68191 9.99941   -16.22088 1.000 24.03453 ? 253 LEU A CB  1 
ATOM   1957 C  CG  . LEU A 1 253 ? 12.27358 8.87475   -15.26458 1.000 27.58890 ? 253 LEU A CG  1 
ATOM   1958 C  CD1 . LEU A 1 253 ? 12.20276 9.37839   -13.82924 1.000 23.12204 ? 253 LEU A CD1 1 
ATOM   1959 C  CD2 . LEU A 1 253 ? 10.93842 8.28560   -15.69245 1.000 29.54725 ? 253 LEU A CD2 1 
ATOM   1960 N  N   . SER A 1 254 ? 14.38162 11.31751  -18.59460 1.000 26.82198 ? 254 SER A N   1 
ATOM   1961 C  CA  . SER A 1 254 ? 14.69559 12.41161  -19.50538 1.000 28.38583 ? 254 SER A CA  1 
ATOM   1962 C  C   . SER A 1 254 ? 14.41167 12.01457  -20.94877 1.000 27.68238 ? 254 SER A C   1 
ATOM   1963 O  O   . SER A 1 254 ? 13.79483 12.77253  -21.70571 1.000 28.15989 ? 254 SER A O   1 
ATOM   1964 C  CB  . SER A 1 254 ? 16.15837 12.82194  -19.33336 1.000 27.61404 ? 254 SER A CB  1 
ATOM   1965 O  OG  . SER A 1 254 ? 16.48470 13.91723  -20.16961 1.000 33.58333 ? 254 SER A OG  1 
ATOM   1966 N  N   . ALA A 1 255 ? 14.84756 10.81629  -21.34370 1.000 27.35998 ? 255 ALA A N   1 
ATOM   1967 C  CA  . ALA A 1 255 ? 14.63155 10.36243  -22.71341 1.000 30.14278 ? 255 ALA A CA  1 
ATOM   1968 C  C   . ALA A 1 255 ? 13.15194 10.12947  -22.99722 1.000 32.54265 ? 255 ALA A C   1 
ATOM   1969 O  O   . ALA A 1 255 ? 12.65727 10.48367  -24.07276 1.000 32.92243 ? 255 ALA A O   1 
ATOM   1970 C  CB  . ALA A 1 255 ? 15.43478 9.08878   -22.97365 1.000 27.74585 ? 255 ALA A CB  1 
ATOM   1971 N  N   . GLN A 1 256 ? 12.42769 9.53846   -22.04555 1.000 34.03381 ? 256 GLN A N   1 
ATOM   1972 C  CA  . GLN A 1 256 ? 11.01977 9.22843   -22.27690 1.000 32.71980 ? 256 GLN A CA  1 
ATOM   1973 C  C   . GLN A 1 256 ? 10.18699 10.48661  -22.48750 1.000 35.66447 ? 256 GLN A C   1 
ATOM   1974 O  O   . GLN A 1 256 ? 9.24041  10.47673  -23.28327 1.000 35.76777 ? 256 GLN A O   1 
ATOM   1975 C  CB  . GLN A 1 256 ? 10.46351 8.41317   -21.10832 1.000 31.93398 ? 256 GLN A CB  1 
ATOM   1976 C  CG  . GLN A 1 256 ? 8.98670  8.07226   -21.23607 1.000 40.86306 ? 256 GLN A CG  1 
ATOM   1977 C  CD  . GLN A 1 256 ? 8.49492  7.16502   -20.12119 1.000 46.41774 ? 256 GLN A CD  1 
ATOM   1978 O  OE1 . GLN A 1 256 ? 9.28917  6.52830   -19.42629 1.000 49.26605 ? 256 GLN A OE1 1 
ATOM   1979 N  NE2 . GLN A 1 256 ? 7.17855  7.10400   -19.94340 1.000 45.14792 ? 256 GLN A NE2 1 
ATOM   1980 N  N   . THR A 1 257 ? 10.51924 11.57671  -21.79642 1.000 29.41058 ? 257 THR A N   1 
ATOM   1981 C  CA  . THR A 1 257 ? 9.72085  12.79334  -21.84951 1.000 29.60908 ? 257 THR A CA  1 
ATOM   1982 C  C   . THR A 1 257 ? 10.31034 13.86984  -22.74981 1.000 31.96932 ? 257 THR A C   1 
ATOM   1983 O  O   . THR A 1 257 ? 9.59992  14.82132  -23.09247 1.000 28.52653 ? 257 THR A O   1 
ATOM   1984 C  CB  . THR A 1 257 ? 9.53597  13.37135  -20.43994 1.000 29.85283 ? 257 THR A CB  1 
ATOM   1985 O  OG1 . THR A 1 257 ? 10.79495 13.84637  -19.94522 1.000 28.20758 ? 257 THR A OG1 1 
ATOM   1986 C  CG2 . THR A 1 257 ? 9.00113  12.30421  -19.50093 1.000 26.09690 ? 257 THR A CG2 1 
ATOM   1987 N  N   . GLY A 1 258 ? 11.57771 13.75076  -23.13645 1.000 26.41983 ? 258 GLY A N   1 
ATOM   1988 C  CA  . GLY A 1 258 ? 12.19664 14.78415  -23.93803 1.000 27.91144 ? 258 GLY A CA  1 
ATOM   1989 C  C   . GLY A 1 258 ? 12.52486 16.05189  -23.18818 1.000 31.69516 ? 258 GLY A C   1 
ATOM   1990 O  O   . GLY A 1 258 ? 12.75822 17.08609  -23.81738 1.000 29.66800 ? 258 GLY A O   1 
ATOM   1991 N  N   . ILE A 1 259 ? 12.54590 16.00607  -21.85640 1.000 27.24401 ? 259 ILE A N   1 
ATOM   1992 C  CA  . ILE A 1 259 ? 12.88885 17.15525  -21.02717 1.000 28.48868 ? 259 ILE A CA  1 
ATOM   1993 C  C   . ILE A 1 259 ? 14.27388 16.91100  -20.44862 1.000 28.16078 ? 259 ILE A C   1 
ATOM   1994 O  O   . ILE A 1 259 ? 14.47501 15.95445  -19.68871 1.000 25.14575 ? 259 ILE A O   1 
ATOM   1995 C  CB  . ILE A 1 259 ? 11.86303 17.38184  -19.90646 1.000 29.18880 ? 259 ILE A CB  1 
ATOM   1996 C  CG1 . ILE A 1 259 ? 10.46214 17.58634  -20.48255 1.000 28.56633 ? 259 ILE A CG1 1 
ATOM   1997 C  CG2 . ILE A 1 259 ? 12.26317 18.58093  -19.06016 1.000 22.77650 ? 259 ILE A CG2 1 
ATOM   1998 C  CD1 . ILE A 1 259 ? 10.24471 18.95828  -21.06347 1.000 32.66589 ? 259 ILE A CD1 1 
ATOM   1999 N  N   . ALA A 1 260 ? 15.22482 17.77382  -20.80304 1.000 28.05018 ? 260 ALA A N   1 
ATOM   2000 C  CA  . ALA A 1 260 ? 16.57980 17.64455  -20.28186 1.000 26.25646 ? 260 ALA A CA  1 
ATOM   2001 C  C   . ALA A 1 260 ? 16.57805 17.77229  -18.76322 1.000 23.94584 ? 260 ALA A C   1 
ATOM   2002 O  O   . ALA A 1 260 ? 15.79663 18.53542  -18.18945 1.000 23.45225 ? 260 ALA A O   1 
ATOM   2003 C  CB  . ALA A 1 260 ? 17.49300 18.70367  -20.90185 1.000 23.14636 ? 260 ALA A CB  1 
ATOM   2004 N  N   . VAL A 1 261 ? 17.46503 17.01589  -18.11073 1.000 26.25288 ? 261 VAL A N   1 
ATOM   2005 C  CA  . VAL A 1 261 ? 17.51528 17.01953  -16.64858 1.000 24.52855 ? 261 VAL A CA  1 
ATOM   2006 C  C   . VAL A 1 261 ? 17.70916 18.43674  -16.12846 1.000 24.52696 ? 261 VAL A C   1 
ATOM   2007 O  O   . VAL A 1 261 ? 17.01274 18.88182  -15.20824 1.000 25.37630 ? 261 VAL A O   1 
ATOM   2008 C  CB  . VAL A 1 261 ? 18.62307 16.07755  -16.14151 1.000 23.92419 ? 261 VAL A CB  1 
ATOM   2009 C  CG1 . VAL A 1 261 ? 18.81571 16.25143  -14.63630 1.000 25.26410 ? 261 VAL A CG1 1 
ATOM   2010 C  CG2 . VAL A 1 261 ? 18.28214 14.63064  -16.46998 1.000 26.09743 ? 261 VAL A CG2 1 
ATOM   2011 N  N   . LEU A 1 262 ? 18.65606 19.17223  -16.71707 1.000 24.01034 ? 262 LEU A N   1 
ATOM   2012 C  CA  . LEU A 1 262 ? 18.92814 20.52658  -16.24862 1.000 24.46265 ? 262 LEU A CA  1 
ATOM   2013 C  C   . LEU A 1 262 ? 17.75009 21.46046  -16.49811 1.000 24.10796 ? 262 LEU A C   1 
ATOM   2014 O  O   . LEU A 1 262 ? 17.52753 22.39327  -15.71745 1.000 25.34605 ? 262 LEU A O   1 
ATOM   2015 C  CB  . LEU A 1 262 ? 20.19490 21.06550  -16.91016 1.000 28.22216 ? 262 LEU A CB  1 
ATOM   2016 C  CG  . LEU A 1 262 ? 21.48549 20.35112  -16.49804 1.000 25.22296 ? 262 LEU A CG  1 
ATOM   2017 C  CD1 . LEU A 1 262 ? 22.69123 20.95432  -17.20356 1.000 27.95547 ? 262 LEU A CD1 1 
ATOM   2018 C  CD2 . LEU A 1 262 ? 21.66620 20.39943  -14.98665 1.000 31.86900 ? 262 LEU A CD2 1 
ATOM   2019 N  N   . ASP A 1 263 ? 16.98732 21.23533  -17.56937 1.000 25.70277 ? 263 ASP A N   1 
ATOM   2020 C  CA  . ASP A 1 263 ? 15.75478 21.99449  -17.75559 1.000 25.31368 ? 263 ASP A CA  1 
ATOM   2021 C  C   . ASP A 1 263 ? 14.77661 21.71654  -16.61961 1.000 25.67520 ? 263 ASP A C   1 
ATOM   2022 O  O   . ASP A 1 263 ? 14.17799 22.64048  -16.05892 1.000 26.32657 ? 263 ASP A O   1 
ATOM   2023 C  CB  . ASP A 1 263 ? 15.12461 21.66579  -19.11064 1.000 26.05891 ? 263 ASP A CB  1 
ATOM   2024 C  CG  . ASP A 1 263 ? 15.92392 22.22194  -20.28269 1.000 28.55774 ? 263 ASP A CG  1 
ATOM   2025 O  OD1 . ASP A 1 263 ? 16.95641 22.88798  -20.05143 1.000 26.57578 ? 263 ASP A OD1 1 
ATOM   2026 O  OD2 . ASP A 1 263 ? 15.51914 21.98726  -21.44210 1.000 31.79824 ? 263 ASP A OD2 1 
ATOM   2027 N  N   . MET A 1 264 ? 14.61014 20.44255  -16.25460 1.000 26.32534 ? 264 MET A N   1 
ATOM   2028 C  CA  . MET A 1 264 ? 13.72923 20.12125  -15.13675 1.000 25.07132 ? 264 MET A CA  1 
ATOM   2029 C  C   . MET A 1 264 ? 14.26385 20.68127  -13.82356 1.000 25.71301 ? 264 MET A C   1 
ATOM   2030 O  O   . MET A 1 264 ? 13.47675 21.05361  -12.94733 1.000 26.58525 ? 264 MET A O   1 
ATOM   2031 C  CB  . MET A 1 264 ? 13.52681 18.60824  -15.02860 1.000 25.87724 ? 264 MET A CB  1 
ATOM   2032 C  CG  . MET A 1 264 ? 12.45902 18.20741  -14.01487 1.000 26.10740 ? 264 MET A CG  1 
ATOM   2033 S  SD  . MET A 1 264 ? 10.78584 18.64426  -14.54135 1.000 29.72620 ? 264 MET A SD  1 
ATOM   2034 C  CE  . MET A 1 264 ? 10.36263 17.21744  -15.53526 1.000 23.11272 ? 264 MET A CE  1 
ATOM   2035 N  N   . CYS A 1 265 ? 15.58798 20.74684  -13.66083 1.000 25.48843 ? 265 CYS A N   1 
ATOM   2036 C  CA  . CYS A 1 265 ? 16.14268 21.39249  -12.47380 1.000 25.28565 ? 265 CYS A CA  1 
ATOM   2037 C  C   . CYS A 1 265 ? 15.73312 22.85794  -12.41078 1.000 26.05249 ? 265 CYS A C   1 
ATOM   2038 O  O   . CYS A 1 265 ? 15.46311 23.39115  -11.32765 1.000 25.10084 ? 265 CYS A O   1 
ATOM   2039 C  CB  . CYS A 1 265 ? 17.66636 21.26492  -12.45800 1.000 22.82214 ? 265 CYS A CB  1 
ATOM   2040 S  SG  . CYS A 1 265 ? 18.29111 19.59652  -12.16797 1.000 24.43720 ? 265 CYS A SG  1 
ATOM   2041 N  N   . ALA A 1 266 ? 15.68147 23.52527  -13.56723 1.000 25.03386 ? 266 ALA A N   1 
ATOM   2042 C  CA  . ALA A 1 266 ? 15.24663 24.91735  -13.60376 1.000 27.76466 ? 266 ALA A CA  1 
ATOM   2043 C  C   . ALA A 1 266 ? 13.80173 25.05615  -13.14408 1.000 24.89676 ? 266 ALA A C   1 
ATOM   2044 O  O   . ALA A 1 266 ? 13.43825 26.05454  -12.51218 1.000 28.36362 ? 266 ALA A O   1 
ATOM   2045 C  CB  . ALA A 1 266 ? 15.42038 25.48590  -15.01200 1.000 25.61934 ? 266 ALA A CB  1 
ATOM   2046 N  N   . SER A 1 267 ? 12.95964 24.06808  -13.45612 1.000 26.58571 ? 267 SER A N   1 
ATOM   2047 C  CA  . SER A 1 267 ? 11.58986 24.08424  -12.95273 1.000 25.06295 ? 267 SER A CA  1 
ATOM   2048 C  C   . SER A 1 267 ? 11.56725 23.91645  -11.43819 1.000 26.37264 ? 267 SER A C   1 
ATOM   2049 O  O   . SER A 1 267 ? 10.87882 24.66045  -10.72890 1.000 25.29149 ? 267 SER A O   1 
ATOM   2050 C  CB  . SER A 1 267 ? 10.76591 22.98723  -13.62956 1.000 28.03672 ? 267 SER A CB  1 
ATOM   2051 O  OG  . SER A 1 267 ? 10.57806 23.25741  -15.00805 1.000 33.13826 ? 267 SER A OG  1 
ATOM   2052 N  N   . LEU A 1 268 ? 12.31957 22.94016  -10.92456 1.000 24.13675 ? 268 LEU A N   1 
ATOM   2053 C  CA  . LEU A 1 268 ? 12.37258 22.72918  -9.48147  1.000 21.87271 ? 268 LEU A CA  1 
ATOM   2054 C  C   . LEU A 1 268 ? 12.90542 23.96302  -8.76559  1.000 24.64784 ? 268 LEU A C   1 
ATOM   2055 O  O   . LEU A 1 268 ? 12.36575 24.37284  -7.73111  1.000 25.52116 ? 268 LEU A O   1 
ATOM   2056 C  CB  . LEU A 1 268 ? 13.23375 21.50931  -9.16295  1.000 22.52198 ? 268 LEU A CB  1 
ATOM   2057 C  CG  . LEU A 1 268 ? 13.41485 21.20674  -7.67478  1.000 23.58487 ? 268 LEU A CG  1 
ATOM   2058 C  CD1 . LEU A 1 268 ? 12.06708 21.13652  -6.98273  1.000 20.92247 ? 268 LEU A CD1 1 
ATOM   2059 C  CD2 . LEU A 1 268 ? 14.18113 19.91316  -7.48898  1.000 23.68286 ? 268 LEU A CD2 1 
ATOM   2060 N  N   . LYS A 1 269 ? 13.97063 24.56391  -9.29845  1.000 26.79922 ? 269 LYS A N   1 
ATOM   2061 C  CA  . LYS A 1 269 ? 14.48506 25.80751  -8.73599  1.000 25.46541 ? 269 LYS A CA  1 
ATOM   2062 C  C   . LYS A 1 269 ? 13.38395 26.85620  -8.63509  1.000 29.36450 ? 269 LYS A C   1 
ATOM   2063 O  O   . LYS A 1 269 ? 13.22514 27.51381  -7.60008  1.000 26.33707 ? 269 LYS A O   1 
ATOM   2064 C  CB  . LYS A 1 269 ? 15.64983 26.31600  -9.58926  1.000 27.44775 ? 269 LYS A CB  1 
ATOM   2065 C  CG  . LYS A 1 269 ? 16.06941 27.75333  -9.31216  1.000 34.21635 ? 269 LYS A CG  1 
ATOM   2066 C  CD  . LYS A 1 269 ? 17.21014 28.17244  -10.23337 1.000 34.30178 ? 269 LYS A CD  1 
ATOM   2067 C  CE  . LYS A 1 269 ? 17.47445 29.66913  -10.15554 1.000 37.93905 ? 269 LYS A CE  1 
ATOM   2068 N  NZ  . LYS A 1 269 ? 18.51441 30.10526  -11.13609 1.000 37.20339 ? 269 LYS A NZ  1 
ATOM   2069 N  N   . GLU A 1 270 ? 12.59822 27.01435  -9.70344  1.000 27.88191 ? 270 GLU A N   1 
ATOM   2070 C  CA  . GLU A 1 270 ? 11.53400 28.01303  -9.69015  1.000 30.73159 ? 270 GLU A CA  1 
ATOM   2071 C  C   . GLU A 1 270 ? 10.47474 27.67991  -8.64387  1.000 31.86587 ? 270 GLU A C   1 
ATOM   2072 O  O   . GLU A 1 270 ? 9.94075  28.57804  -7.98131  1.000 29.31240 ? 270 GLU A O   1 
ATOM   2073 C  CB  . GLU A 1 270 ? 10.90618 28.12570  -11.07926 1.000 32.94494 ? 270 GLU A CB  1 
ATOM   2074 C  CG  . GLU A 1 270 ? 10.53360 29.54576  -11.46755 1.000 37.24369 ? 270 GLU A CG  1 
ATOM   2075 C  CD  . GLU A 1 270 ? 11.72545 30.48522  -11.42862 1.000 42.54357 ? 270 GLU A CD  1 
ATOM   2076 O  OE1 . GLU A 1 270 ? 12.86984 30.00013  -11.55925 1.000 38.98527 ? 270 GLU A OE1 1 
ATOM   2077 O  OE2 . GLU A 1 270 ? 11.52103 31.70636  -11.26047 1.000 44.99285 ? 270 GLU A OE2 1 
ATOM   2078 N  N   . LEU A 1 271 ? 10.15866 26.39239  -8.47974  1.000 28.84634 ? 271 LEU A N   1 
ATOM   2079 C  CA  . LEU A 1 271 ? 9.18957  25.99017  -7.46353  1.000 29.15290 ? 271 LEU A CA  1 
ATOM   2080 C  C   . LEU A 1 271 ? 9.72458  26.23392  -6.05655  1.000 28.86638 ? 271 LEU A C   1 
ATOM   2081 O  O   . LEU A 1 271 ? 8.96907  26.61987  -5.15709  1.000 32.99546 ? 271 LEU A O   1 
ATOM   2082 C  CB  . LEU A 1 271 ? 8.81993  24.51801  -7.64726  1.000 27.16561 ? 271 LEU A CB  1 
ATOM   2083 C  CG  . LEU A 1 271 ? 8.04951  24.13117  -8.91418  1.000 27.09902 ? 271 LEU A CG  1 
ATOM   2084 C  CD1 . LEU A 1 271 ? 8.08556  22.62791  -9.12436  1.000 23.56703 ? 271 LEU A CD1 1 
ATOM   2085 C  CD2 . LEU A 1 271 ? 6.61144  24.62277  -8.83551  1.000 28.65573 ? 271 LEU A CD2 1 
ATOM   2086 N  N   . LEU A 1 272 ? 11.02341 26.00908  -5.84222  1.000 28.94953 ? 272 LEU A N   1 
ATOM   2087 C  CA  . LEU A 1 272 ? 11.59518 26.21715  -4.51518  1.000 25.54075 ? 272 LEU A CA  1 
ATOM   2088 C  C   . LEU A 1 272 ? 11.61577 27.69521  -4.14466  1.000 32.04827 ? 272 LEU A C   1 
ATOM   2089 O  O   . LEU A 1 272 ? 11.40297 28.05240  -2.97997  1.000 31.60350 ? 272 LEU A O   1 
ATOM   2090 C  CB  . LEU A 1 272 ? 13.00526 25.62920  -4.45156  1.000 27.30743 ? 272 LEU A CB  1 
ATOM   2091 C  CG  . LEU A 1 272 ? 13.11594 24.10155  -4.43144  1.000 26.01448 ? 272 LEU A CG  1 
ATOM   2092 C  CD1 . LEU A 1 272 ? 14.54530 23.66405  -4.70496  1.000 24.39913 ? 272 LEU A CD1 1 
ATOM   2093 C  CD2 . LEU A 1 272 ? 12.63660 23.54912  -3.09514  1.000 26.79807 ? 272 LEU A CD2 1 
ATOM   2094 N  N   . GLN A 1 273 ? 11.86669 28.56798  -5.11990  1.000 31.30076 ? 273 GLN A N   1 
ATOM   2095 C  CA  . GLN A 1 273 ? 11.99195 29.99577  -4.85989  1.000 34.90570 ? 273 GLN A CA  1 
ATOM   2096 C  C   . GLN A 1 273 ? 10.65831 30.73387  -4.86097  1.000 36.67770 ? 273 GLN A C   1 
ATOM   2097 O  O   . GLN A 1 273 ? 10.58897 31.85278  -4.33959  1.000 39.64893 ? 273 GLN A O   1 
ATOM   2098 C  CB  . GLN A 1 273 ? 12.92689 30.63915  -5.89291  1.000 34.17688 ? 273 GLN A CB  1 
ATOM   2099 C  CG  . GLN A 1 273 ? 14.37688 30.16669  -5.80809  1.000 33.16344 ? 273 GLN A CG  1 
ATOM   2100 C  CD  . GLN A 1 273 ? 15.25874 30.77245  -6.88978  1.000 33.71901 ? 273 GLN A CD  1 
ATOM   2101 O  OE1 . GLN A 1 273 ? 14.77007 31.24410  -7.91611  1.000 37.38979 ? 273 GLN A OE1 1 
ATOM   2102 N  NE2 . GLN A 1 273 ? 16.56668 30.76148  -6.66085  1.000 34.61823 ? 273 GLN A NE2 1 
ATOM   2103 N  N   . ASN A 1 274 ? 9.60019  30.14426  -5.42236  1.000 32.20172 ? 274 ASN A N   1 
ATOM   2104 C  CA  . ASN A 1 274 ? 8.31931  30.82865  -5.53093  1.000 36.50069 ? 274 ASN A CA  1 
ATOM   2105 C  C   . ASN A 1 274 ? 7.13914  30.04063  -4.97807  1.000 38.90601 ? 274 ASN A C   1 
ATOM   2106 O  O   . ASN A 1 274 ? 6.03098  30.58412  -4.92660  1.000 37.04995 ? 274 ASN A O   1 
ATOM   2107 C  CB  . ASN A 1 274 ? 8.03081  31.19275  -6.99697  1.000 36.45850 ? 274 ASN A CB  1 
ATOM   2108 C  CG  . ASN A 1 274 ? 9.16550  31.96990  -7.63901  1.000 38.48198 ? 274 ASN A CG  1 
ATOM   2109 O  OD1 . ASN A 1 274 ? 9.62999  31.62861  -8.72610  1.000 41.73125 ? 274 ASN A OD1 1 
ATOM   2110 N  ND2 . ASN A 1 274 ? 9.62338  33.01707  -6.96290  1.000 42.57098 ? 274 ASN A ND2 1 
ATOM   2111 N  N   . GLY A 1 275 ? 7.33564  28.79376  -4.55907  1.000 39.18416 ? 275 GLY A N   1 
ATOM   2112 C  CA  . GLY A 1 275 ? 6.22792  27.96497  -4.12359  1.000 39.27188 ? 275 GLY A CA  1 
ATOM   2113 C  C   . GLY A 1 275 ? 5.33934  27.57229  -5.29236  1.000 39.08975 ? 275 GLY A C   1 
ATOM   2114 O  O   . GLY A 1 275 ? 5.61583  27.85805  -6.45489  1.000 40.28693 ? 275 GLY A O   1 
ATOM   2115 N  N   . MET A 1 276 ? 4.24226  26.89381  -4.96155  1.000 43.10473 ? 276 MET A N   1 
ATOM   2116 C  CA  . MET A 1 276 ? 3.27279  26.49233  -5.97161  1.000 41.83886 ? 276 MET A CA  1 
ATOM   2117 C  C   . MET A 1 276 ? 2.14681  27.50273  -6.14817  1.000 44.58433 ? 276 MET A C   1 
ATOM   2118 O  O   . MET A 1 276 ? 1.33099  27.34468  -7.06415  1.000 43.57278 ? 276 MET A O   1 
ATOM   2119 C  CB  . MET A 1 276 ? 2.68410  25.11847  -5.63094  1.000 42.25231 ? 276 MET A CB  1 
ATOM   2120 C  CG  . MET A 1 276 ? 3.71459  24.00226  -5.59868  1.000 39.68448 ? 276 MET A CG  1 
ATOM   2121 S  SD  . MET A 1 276 ? 2.96945  22.36298  -5.57584  1.000 43.35523 ? 276 MET A SD  1 
ATOM   2122 C  CE  . MET A 1 276 ? 4.42639  21.34380  -5.37248  1.000 33.24694 ? 276 MET A CE  1 
ATOM   2123 N  N   . ASN A 1 277 ? 2.08930  28.53259  -5.30540  1.000 44.65709 ? 277 ASN A N   1 
ATOM   2124 C  CA  . ASN A 1 277 ? 1.08613  29.58776  -5.41690  1.000 42.67927 ? 277 ASN A CA  1 
ATOM   2125 C  C   . ASN A 1 277 ? -0.32333 29.00120  -5.46023  1.000 46.51162 ? 277 ASN A C   1 
ATOM   2126 O  O   . ASN A 1 277 ? -1.16176 29.38440  -6.27951  1.000 44.86985 ? 277 ASN A O   1 
ATOM   2127 C  CB  . ASN A 1 277 ? 1.35484  30.46795  -6.63873  1.000 42.95922 ? 277 ASN A CB  1 
ATOM   2128 N  N   . GLY A 1 278 ? -0.57901 28.04956  -4.56314  1.000 41.44210 ? 278 GLY A N   1 
ATOM   2129 C  CA  . GLY A 1 278 ? -1.89245 27.45452  -4.43519  1.000 42.06953 ? 278 GLY A CA  1 
ATOM   2130 C  C   . GLY A 1 278 ? -2.21989 26.36270  -5.43054  1.000 39.27062 ? 278 GLY A C   1 
ATOM   2131 O  O   . GLY A 1 278 ? -3.31315 25.78869  -5.35240  1.000 37.62852 ? 278 GLY A O   1 
ATOM   2132 N  N   . ARG A 1 279 ? -1.32268 26.05739  -6.36366  1.000 43.19123 ? 279 ARG A N   1 
ATOM   2133 C  CA  . ARG A 1 279 ? -1.55348 24.97944  -7.31233  1.000 36.80639 ? 279 ARG A CA  1 
ATOM   2134 C  C   . ARG A 1 279 ? -1.17251 23.63938  -6.68318  1.000 36.22668 ? 279 ARG A C   1 
ATOM   2135 O  O   . ARG A 1 279 ? -0.73397 23.56230  -5.53164  1.000 36.22791 ? 279 ARG A O   1 
ATOM   2136 C  CB  . ARG A 1 279 ? -0.77324 25.22837  -8.60184  1.000 36.69679 ? 279 ARG A CB  1 
ATOM   2137 N  N   . THR A 1 280 ? -1.34856 22.56367  -7.44685  1.000 28.24383 ? 280 THR A N   1 
ATOM   2138 C  CA  . THR A 1 280 ? -1.01115 21.22769  -6.98104  1.000 29.22855 ? 280 THR A CA  1 
ATOM   2139 C  C   . THR A 1 280 ? -0.31961 20.45905  -8.09691  1.000 28.99659 ? 280 THR A C   1 
ATOM   2140 O  O   . THR A 1 280 ? -0.44994 20.78311  -9.28051  1.000 29.86482 ? 280 THR A O   1 
ATOM   2141 C  CB  . THR A 1 280 ? -2.24903 20.45235  -6.50293  1.000 31.77665 ? 280 THR A CB  1 
ATOM   2142 O  OG1 . THR A 1 280 ? -3.20977 20.37192  -7.56307  1.000 31.32500 ? 280 THR A OG1 1 
ATOM   2143 C  CG2 . THR A 1 280 ? -2.87897 21.13545  -5.29442  1.000 27.71617 ? 280 THR A CG2 1 
ATOM   2144 N  N   . ILE A 1 281 ? 0.42225  19.42927  -7.69711  1.000 26.03520 ? 281 ILE A N   1 
ATOM   2145 C  CA  . ILE A 1 281 ? 1.14194  18.55527  -8.61432  1.000 24.52129 ? 281 ILE A CA  1 
ATOM   2146 C  C   . ILE A 1 281 ? 0.83149  17.11761  -8.22678  1.000 29.16228 ? 281 ILE A C   1 
ATOM   2147 O  O   . ILE A 1 281 ? 1.15492  16.68875  -7.11122  1.000 26.63827 ? 281 ILE A O   1 
ATOM   2148 C  CB  . ILE A 1 281 ? 2.65793  18.80877  -8.58630  1.000 25.47610 ? 281 ILE A CB  1 
ATOM   2149 C  CG1 . ILE A 1 281 ? 2.96118  20.25236  -8.99519  1.000 25.33705 ? 281 ILE A CG1 1 
ATOM   2150 C  CG2 . ILE A 1 281 ? 3.37439  17.82227  -9.49741  1.000 24.85565 ? 281 ILE A CG2 1 
ATOM   2151 C  CD1 . ILE A 1 281 ? 4.43428  20.56907  -9.07820  1.000 28.93343 ? 281 ILE A CD1 1 
ATOM   2152 N  N   . LEU A 1 282 ? 0.20708  16.37542  -9.14139  1.000 25.88284 ? 282 LEU A N   1 
ATOM   2153 C  CA  . LEU A 1 282 ? -0.19991 14.99692  -8.87412  1.000 26.27338 ? 282 LEU A CA  1 
ATOM   2154 C  C   . LEU A 1 282 ? -0.98272 14.90101  -7.56623  1.000 27.06743 ? 282 LEU A C   1 
ATOM   2155 O  O   . LEU A 1 282 ? -0.78468 13.98778  -6.76086  1.000 26.28847 ? 282 LEU A O   1 
ATOM   2156 C  CB  . LEU A 1 282 ? 1.00944  14.06010  -8.85823  1.000 24.95138 ? 282 LEU A CB  1 
ATOM   2157 C  CG  . LEU A 1 282 ? 1.62894  13.76962  -10.22538 1.000 28.08407 ? 282 LEU A CG  1 
ATOM   2158 C  CD1 . LEU A 1 282 ? 2.86468  12.89153  -10.09020 1.000 23.45823 ? 282 LEU A CD1 1 
ATOM   2159 C  CD2 . LEU A 1 282 ? 0.59982  13.10940  -11.13077 1.000 26.91879 ? 282 LEU A CD2 1 
ATOM   2160 N  N   . GLY A 1 283 ? -1.87748 15.86401  -7.35088  1.000 27.34948 ? 283 GLY A N   1 
ATOM   2161 C  CA  . GLY A 1 283 ? -2.72391 15.85985  -6.17482  1.000 30.92090 ? 283 GLY A CA  1 
ATOM   2162 C  C   . GLY A 1 283 ? -2.05002 16.25901  -4.88330  1.000 31.11049 ? 283 GLY A C   1 
ATOM   2163 O  O   . GLY A 1 283 ? -2.64563 16.08393  -3.81657  1.000 34.13352 ? 283 GLY A O   1 
ATOM   2164 N  N   . SER A 1 284 ? -0.83199 16.79281  -4.93813  1.000 26.38505 ? 284 SER A N   1 
ATOM   2165 C  CA  . SER A 1 284 ? -0.09710 17.20219  -3.74984  1.000 27.79611 ? 284 SER A CA  1 
ATOM   2166 C  C   . SER A 1 284 ? 0.24945  18.68273  -3.82893  1.000 28.98023 ? 284 SER A C   1 
ATOM   2167 O  O   . SER A 1 284 ? 0.63892  19.18511  -4.88872  1.000 28.06617 ? 284 SER A O   1 
ATOM   2168 C  CB  . SER A 1 284 ? 1.18504  16.37882  -3.57691  1.000 26.27085 ? 284 SER A CB  1 
ATOM   2169 O  OG  . SER A 1 284 ? 1.94652  16.85467  -2.47647  1.000 26.19376 ? 284 SER A OG  1 
ATOM   2170 N  N   . ALA A 1 285 ? 0.11148  19.37592  -2.69928  1.000 27.05338 ? 285 ALA A N   1 
ATOM   2171 C  CA  . ALA A 1 285 ? 0.46095  20.78527  -2.59872  1.000 25.39919 ? 285 ALA A CA  1 
ATOM   2172 C  C   . ALA A 1 285 ? 1.87676  21.00238  -2.07982  1.000 28.29814 ? 285 ALA A C   1 
ATOM   2173 O  O   . ALA A 1 285 ? 2.23609  22.13443  -1.74228  1.000 29.52275 ? 285 ALA A O   1 
ATOM   2174 C  CB  . ALA A 1 285 ? -0.54032 21.51793  -1.70544  1.000 29.71308 ? 285 ALA A CB  1 
ATOM   2175 N  N   . LEU A 1 286 ? 2.68187  19.94878  -2.00605  1.000 23.39977 ? 286 LEU A N   1 
ATOM   2176 C  CA  . LEU A 1 286 ? 4.08743  20.04618  -1.64484  1.000 27.93279 ? 286 LEU A CA  1 
ATOM   2177 C  C   . LEU A 1 286 ? 4.89977  19.15159  -2.57294  1.000 27.69515 ? 286 LEU A C   1 
ATOM   2178 O  O   . LEU A 1 286 ? 4.35441  18.33484  -3.32055  1.000 25.77955 ? 286 LEU A O   1 
ATOM   2179 C  CB  . LEU A 1 286 ? 4.32093  19.66907  -0.17298  1.000 29.50205 ? 286 LEU A CB  1 
ATOM   2180 C  CG  . LEU A 1 286 ? 3.82130  18.32562  0.36176   1.000 28.70243 ? 286 LEU A CG  1 
ATOM   2181 C  CD1 . LEU A 1 286 ? 4.72389  17.17719  -0.06816  1.000 33.57455 ? 286 LEU A CD1 1 
ATOM   2182 C  CD2 . LEU A 1 286 ? 3.70939  18.38244  1.88250   1.000 31.02630 ? 286 LEU A CD2 1 
ATOM   2183 N  N   . LEU A 1 287 ? 6.21954  19.31370  -2.52194  1.000 26.31529 ? 287 LEU A N   1 
ATOM   2184 C  CA  . LEU A 1 287 ? 7.12036  18.56528  -3.39068  1.000 26.92897 ? 287 LEU A CA  1 
ATOM   2185 C  C   . LEU A 1 287 ? 7.41223  17.20199  -2.77259  1.000 26.12770 ? 287 LEU A C   1 
ATOM   2186 O  O   . LEU A 1 287 ? 7.95263  17.11951  -1.66593  1.000 25.04705 ? 287 LEU A O   1 
ATOM   2187 C  CB  . LEU A 1 287 ? 8.40609  19.35822  -3.61216  1.000 23.83962 ? 287 LEU A CB  1 
ATOM   2188 C  CG  . LEU A 1 287 ? 8.20683  20.75549  -4.20647  1.000 28.76501 ? 287 LEU A CG  1 
ATOM   2189 C  CD1 . LEU A 1 287 ? 9.51731  21.52803  -4.25677  1.000 29.03509 ? 287 LEU A CD1 1 
ATOM   2190 C  CD2 . LEU A 1 287 ? 7.58596  20.66600  -5.59512  1.000 31.66122 ? 287 LEU A CD2 1 
ATOM   2191 N  N   . GLU A 1 288 ? 7.06907  16.13644  -3.49222  1.000 24.44868 ? 288 GLU A N   1 
ATOM   2192 C  CA  A GLU A 1 288 ? 7.19107  14.77815  -2.97887  0.500 23.41178 ? 288 GLU A CA  1 
ATOM   2193 C  CA  B GLU A 1 288 ? 7.19032  14.77722  -2.98110  0.500 22.90490 ? 288 GLU A CA  1 
ATOM   2194 C  C   . GLU A 1 288 ? 8.58205  14.22626  -3.26755  1.000 24.53770 ? 288 GLU A C   1 
ATOM   2195 O  O   . GLU A 1 288 ? 9.07789  14.33100  -4.39351  1.000 24.11262 ? 288 GLU A O   1 
ATOM   2196 C  CB  A GLU A 1 288 ? 6.12011  13.87862  -3.59964  0.500 23.85216 ? 288 GLU A CB  1 
ATOM   2197 C  CB  B GLU A 1 288 ? 6.12350  13.87612  -3.60733  0.500 23.69261 ? 288 GLU A CB  1 
ATOM   2198 C  CG  A GLU A 1 288 ? 4.69924  14.34682  -3.33675  0.500 24.44855 ? 288 GLU A CG  1 
ATOM   2199 C  CG  B GLU A 1 288 ? 6.16907  12.44189  -3.12373  0.500 24.47548 ? 288 GLU A CG  1 
ATOM   2200 C  CD  A GLU A 1 288 ? 4.25819  14.09333  -1.90574  0.500 26.28711 ? 288 GLU A CD  1 
ATOM   2201 C  CD  B GLU A 1 288 ? 5.98278  12.33500  -1.62424  0.500 26.29291 ? 288 GLU A CD  1 
ATOM   2202 O  OE1 A GLU A 1 288 ? 4.63380  13.04007  -1.34951  0.500 27.71739 ? 288 GLU A OE1 1 
ATOM   2203 O  OE1 B GLU A 1 288 ? 5.41470  13.27561  -1.02690  0.500 29.20457 ? 288 GLU A OE1 1 
ATOM   2204 O  OE2 A GLU A 1 288 ? 3.53713  14.94241  -1.33879  0.500 21.95779 ? 288 GLU A OE2 1 
ATOM   2205 O  OE2 B GLU A 1 288 ? 6.41201  11.31609  -1.04265  0.500 25.09889 ? 288 GLU A OE2 1 
ATOM   2206 N  N   . ASP A 1 289 ? 9.20895  13.62219  -2.24931  1.000 22.85874 ? 289 ASP A N   1 
ATOM   2207 C  CA  . ASP A 1 289 ? 10.56646 13.10026  -2.38494  1.000 23.87015 ? 289 ASP A CA  1 
ATOM   2208 C  C   . ASP A 1 289 ? 10.67727 11.62343  -2.01849  1.000 23.10723 ? 289 ASP A C   1 
ATOM   2209 O  O   . ASP A 1 289 ? 11.78568 11.13244  -1.78808  1.000 23.87455 ? 289 ASP A O   1 
ATOM   2210 C  CB  . ASP A 1 289 ? 11.54567 13.93018  -1.54611  1.000 20.64641 ? 289 ASP A CB  1 
ATOM   2211 C  CG  . ASP A 1 289 ? 11.55928 13.53433  -0.06973  1.000 25.26356 ? 289 ASP A CG  1 
ATOM   2212 O  OD1 . ASP A 1 289 ? 10.55480 12.99183  0.43315   1.000 22.88789 ? 289 ASP A OD1 1 
ATOM   2213 O  OD2 . ASP A 1 289 ? 12.59121 13.77602  0.59343   1.000 23.81613 ? 289 ASP A OD2 1 
ATOM   2214 N  N   . GLU A 1 290 ? 9.56298  10.89278  -1.97218  1.000 20.04447 ? 290 GLU A N   1 
ATOM   2215 C  CA  . GLU A 1 290 ? 9.59538  9.48687   -1.58371  1.000 24.73312 ? 290 GLU A CA  1 
ATOM   2216 C  C   . GLU A 1 290 ? 9.37445  8.54243   -2.76399  1.000 28.42068 ? 290 GLU A C   1 
ATOM   2217 O  O   . GLU A 1 290 ? 9.08541  7.35843   -2.55925  1.000 28.54368 ? 290 GLU A O   1 
ATOM   2218 C  CB  . GLU A 1 290 ? 8.57984  9.21876   -0.46922  1.000 28.74130 ? 290 GLU A CB  1 
ATOM   2219 C  CG  . GLU A 1 290 ? 8.83692  10.04332  0.78934   1.000 27.77682 ? 290 GLU A CG  1 
ATOM   2220 C  CD  . GLU A 1 290 ? 8.76319  9.22858   2.07585   1.000 35.46345 ? 290 GLU A CD  1 
ATOM   2221 O  OE1 . GLU A 1 290 ? 7.98399  8.25144   2.13200   1.000 36.25874 ? 290 GLU A OE1 1 
ATOM   2222 O  OE2 . GLU A 1 290 ? 9.48969  9.57174   3.03707   1.000 36.38673 ? 290 GLU A OE2 1 
ATOM   2223 N  N   . PHE A 1 291 ? 9.52438  9.03402   -3.99427  1.000 22.65197 ? 291 PHE A N   1 
ATOM   2224 C  CA  . PHE A 1 291 ? 9.51984  8.19685   -5.18924  1.000 25.10908 ? 291 PHE A CA  1 
ATOM   2225 C  C   . PHE A 1 291 ? 10.90805 8.21899   -5.81250  1.000 22.84613 ? 291 PHE A C   1 
ATOM   2226 O  O   . PHE A 1 291 ? 11.41831 9.29101   -6.15454  1.000 20.97840 ? 291 PHE A O   1 
ATOM   2227 C  CB  . PHE A 1 291 ? 8.48982  8.67714   -6.21127  1.000 29.43454 ? 291 PHE A CB  1 
ATOM   2228 C  CG  . PHE A 1 291 ? 7.06671  8.49975   -5.77844  1.000 29.36446 ? 291 PHE A CG  1 
ATOM   2229 C  CD1 . PHE A 1 291 ? 6.43660  7.27269   -5.90864  1.000 31.49265 ? 291 PHE A CD1 1 
ATOM   2230 C  CD2 . PHE A 1 291 ? 6.34996  9.56782   -5.26895  1.000 26.21012 ? 291 PHE A CD2 1 
ATOM   2231 C  CE1 . PHE A 1 291 ? 5.11931  7.11044   -5.52139  1.000 33.19312 ? 291 PHE A CE1 1 
ATOM   2232 C  CE2 . PHE A 1 291 ? 5.03456  9.41411   -4.87888  1.000 33.02500 ? 291 PHE A CE2 1 
ATOM   2233 C  CZ  . PHE A 1 291 ? 4.41762  8.18264   -5.00445  1.000 32.37624 ? 291 PHE A CZ  1 
ATOM   2234 N  N   . THR A 1 292 ? 11.50726 7.04364   -5.97195  1.000 23.13997 ? 292 THR A N   1 
ATOM   2235 C  CA  . THR A 1 292 ? 12.78517 6.94654   -6.65601  1.000 22.93504 ? 292 THR A CA  1 
ATOM   2236 C  C   . THR A 1 292 ? 12.58424 6.91692   -8.16752  1.000 28.51962 ? 292 THR A C   1 
ATOM   2237 O  O   . THR A 1 292 ? 11.50676 6.56566   -8.65671  1.000 26.39410 ? 292 THR A O   1 
ATOM   2238 C  CB  . THR A 1 292 ? 13.52898 5.69096   -6.22237  1.000 25.16258 ? 292 THR A CB  1 
ATOM   2239 O  OG1 . THR A 1 292 ? 12.88562 4.54149   -6.78717  1.000 26.33486 ? 292 THR A OG1 1 
ATOM   2240 C  CG2 . THR A 1 292 ? 13.53232 5.57191   -4.71117  1.000 26.89544 ? 292 THR A CG2 1 
ATOM   2241 N  N   . PRO A 1 293 ? 13.61119 7.28753   -8.93485  1.000 25.07002 ? 293 PRO A N   1 
ATOM   2242 C  CA  . PRO A 1 293 ? 13.51029 7.14275   -10.39578 1.000 25.56422 ? 293 PRO A CA  1 
ATOM   2243 C  C   . PRO A 1 293 ? 13.05838 5.75723   -10.82228 1.000 26.29897 ? 293 PRO A C   1 
ATOM   2244 O  O   . PRO A 1 293 ? 12.27469 5.63024   -11.76954 1.000 27.79650 ? 293 PRO A O   1 
ATOM   2245 C  CB  . PRO A 1 293 ? 14.93439 7.45607   -10.86924 1.000 24.40394 ? 293 PRO A CB  1 
ATOM   2246 C  CG  . PRO A 1 293 ? 15.45910 8.39991   -9.83280  1.000 23.63245 ? 293 PRO A CG  1 
ATOM   2247 C  CD  . PRO A 1 293 ? 14.87121 7.93126   -8.52444  1.000 26.74672 ? 293 PRO A CD  1 
ATOM   2248 N  N   . PHE A 1 294 ? 13.52379 4.71107   -10.13522 1.000 29.93136 ? 294 PHE A N   1 
ATOM   2249 C  CA  . PHE A 1 294 ? 13.08538 3.35805   -10.46329 1.000 30.62289 ? 294 PHE A CA  1 
ATOM   2250 C  C   . PHE A 1 294 ? 11.60134 3.17289   -10.17249 1.000 29.99247 ? 294 PHE A C   1 
ATOM   2251 O  O   . PHE A 1 294 ? 10.88284 2.54459   -10.96028 1.000 30.86293 ? 294 PHE A O   1 
ATOM   2252 C  CB  . PHE A 1 294 ? 13.91789 2.33326   -9.69217  1.000 32.10474 ? 294 PHE A CB  1 
ATOM   2253 N  N   . ASP A 1 295 ? 11.12122 3.71315   -9.04868  1.000 29.24578 ? 295 ASP A N   1 
ATOM   2254 C  CA  . ASP A 1 295 ? 9.69734  3.61599   -8.73983  1.000 30.60723 ? 295 ASP A CA  1 
ATOM   2255 C  C   . ASP A 1 295 ? 8.85229  4.23948   -9.84465  1.000 34.21189 ? 295 ASP A C   1 
ATOM   2256 O  O   . ASP A 1 295 ? 7.83264  3.67093   -10.25380 1.000 34.15017 ? 295 ASP A O   1 
ATOM   2257 C  CB  . ASP A 1 295 ? 9.39572  4.28655   -7.39851  1.000 27.55470 ? 295 ASP A CB  1 
ATOM   2258 C  CG  . ASP A 1 295 ? 10.10117 3.61555   -6.23244  1.000 30.56001 ? 295 ASP A CG  1 
ATOM   2259 O  OD1 . ASP A 1 295 ? 10.70125 2.53734   -6.43140  1.000 32.27069 ? 295 ASP A OD1 1 
ATOM   2260 O  OD2 . ASP A 1 295 ? 10.05988 4.17324   -5.11505  1.000 28.55693 ? 295 ASP A OD2 1 
ATOM   2261 N  N   . VAL A 1 296 ? 9.26191  5.40994   -10.34068 1.000 31.12568 ? 296 VAL A N   1 
ATOM   2262 C  CA  . VAL A 1 296 ? 8.48558  6.09971   -11.36823 1.000 32.20381 ? 296 VAL A CA  1 
ATOM   2263 C  C   . VAL A 1 296 ? 8.40716  5.26091   -12.63748 1.000 34.09025 ? 296 VAL A C   1 
ATOM   2264 O  O   . VAL A 1 296 ? 7.34175  5.13980   -13.25517 1.000 33.88851 ? 296 VAL A O   1 
ATOM   2265 C  CB  . VAL A 1 296 ? 9.08509  7.48971   -11.65001 1.000 30.76219 ? 296 VAL A CB  1 
ATOM   2266 C  CG1 . VAL A 1 296 ? 8.42139  8.10817   -12.87123 1.000 30.60018 ? 296 VAL A CG1 1 
ATOM   2267 C  CG2 . VAL A 1 296 ? 8.92683  8.39396   -10.43611 1.000 26.82560 ? 296 VAL A CG2 1 
ATOM   2268 N  N   . VAL A 1 297 ? 9.53316  4.67891   -13.05297 1.000 32.46575 ? 297 VAL A N   1 
ATOM   2269 C  CA  . VAL A 1 297 ? 9.54128  3.85586   -14.25808 1.000 33.72894 ? 297 VAL A CA  1 
ATOM   2270 C  C   . VAL A 1 297 ? 8.69415  2.60577   -14.05783 1.000 36.95363 ? 297 VAL A C   1 
ATOM   2271 O  O   . VAL A 1 297 ? 7.90506  2.22862   -14.93232 1.000 40.19527 ? 297 VAL A O   1 
ATOM   2272 C  CB  . VAL A 1 297 ? 10.98649 3.50640   -14.65630 1.000 32.70119 ? 297 VAL A CB  1 
ATOM   2273 C  CG1 . VAL A 1 297 ? 10.99347 2.43377   -15.73646 1.000 30.87696 ? 297 VAL A CG1 1 
ATOM   2274 C  CG2 . VAL A 1 297 ? 11.71801 4.75389   -15.13672 1.000 31.42801 ? 297 VAL A CG2 1 
ATOM   2275 N  N   . ARG A 1 298 ? 8.84835  1.93886   -12.91250 1.000 38.17607 ? 298 ARG A N   1 
ATOM   2276 C  CA  . ARG A 1 298 ? 8.00768  0.78974   -12.59392 1.000 38.52061 ? 298 ARG A CA  1 
ATOM   2277 C  C   . ARG A 1 298 ? 6.53322  1.13438   -12.76331 1.000 39.84953 ? 298 ARG A C   1 
ATOM   2278 O  O   . ARG A 1 298 ? 5.82480  0.53147   -13.57671 1.000 43.13989 ? 298 ARG A O   1 
ATOM   2279 C  CB  . ARG A 1 298 ? 8.29164  0.31280   -11.16444 1.000 40.48912 ? 298 ARG A CB  1 
ATOM   2280 C  CG  . ARG A 1 298 ? 7.40847  -0.84496  -10.69382 1.000 43.57022 ? 298 ARG A CG  1 
ATOM   2281 C  CD  . ARG A 1 298 ? 7.73032  -1.26982  -9.25801  1.000 43.62605 ? 298 ARG A CD  1 
ATOM   2282 N  NE  . ARG A 1 298 ? 7.30468  -0.28864  -8.26305  1.000 44.20306 ? 298 ARG A NE  1 
ATOM   2283 C  CZ  . ARG A 1 298 ? 6.33985  -0.48314  -7.37193  1.000 37.21208 ? 298 ARG A CZ  1 
ATOM   2284 N  NH1 . ARG A 1 298 ? 5.67600  -1.62641  -7.30615  1.000 37.31054 ? 298 ARG A NH1 1 
ATOM   2285 N  NH2 . ARG A 1 298 ? 6.03815  0.49171   -6.52003  1.000 36.86639 ? 298 ARG A NH2 1 
ATOM   2286 N  N   . GLN A 1 299 ? 6.05681  2.12177   -12.00507 1.000 37.58253 ? 299 GLN A N   1 
ATOM   2287 C  CA  . GLN A 1 299 ? 4.63818  2.45539   -12.04585 1.000 37.96884 ? 299 GLN A CA  1 
ATOM   2288 C  C   . GLN A 1 299 ? 4.21738  2.88917   -13.44280 1.000 42.64125 ? 299 GLN A C   1 
ATOM   2289 O  O   . GLN A 1 299 ? 3.18463  2.44146   -13.95687 1.000 46.09445 ? 299 GLN A O   1 
ATOM   2290 C  CB  . GLN A 1 299 ? 4.32942  3.54442   -11.01769 1.000 38.20233 ? 299 GLN A CB  1 
ATOM   2291 C  CG  . GLN A 1 299 ? 2.85136  3.85668   -10.86537 1.000 34.70495 ? 299 GLN A CG  1 
ATOM   2292 C  CD  . GLN A 1 299 ? 2.51633  4.50073   -9.52881  1.000 32.46507 ? 299 GLN A CD  1 
ATOM   2293 O  OE1 . GLN A 1 299 ? 1.39862  4.97139   -9.32219  1.000 32.37614 ? 299 GLN A OE1 1 
ATOM   2294 N  NE2 . GLN A 1 299 ? 3.48044  4.51608   -8.61250  1.000 31.72771 ? 299 GLN A NE2 1 
ATOM   2295 N  N   . CYS A 1 300 ? 5.01562  3.74930   -14.07891 1.000 39.86569 ? 300 CYS A N   1 
ATOM   2296 C  CA  . CYS A 1 300 ? 4.74192  4.23708   -15.42429 1.000 42.14916 ? 300 CYS A CA  1 
ATOM   2297 C  C   . CYS A 1 300 ? 5.18336  3.25764   -16.50726 1.000 44.85021 ? 300 CYS A C   1 
ATOM   2298 O  O   . CYS A 1 300 ? 5.49475  3.68561   -17.62749 1.000 49.76678 ? 300 CYS A O   1 
ATOM   2299 C  CB  . CYS A 1 300 ? 5.41282  5.59650   -15.63910 1.000 40.47103 ? 300 CYS A CB  1 
ATOM   2300 S  SG  . CYS A 1 300 ? 4.72236  6.99295   -14.70831 1.000 46.00362 ? 300 CYS A SG  1 
ATOM   2301 N  N   . SER A 1 301 ? 5.22714  1.96036   -16.20687 1.000 44.38905 ? 301 SER A N   1 
ATOM   2302 C  CA  . SER A 1 301 ? 5.58591  0.95550   -17.20419 1.000 44.10225 ? 301 SER A CA  1 
ATOM   2303 C  C   . SER A 1 301 ? 4.81484  -0.34532  -17.01086 1.000 47.35637 ? 301 SER A C   1 
ATOM   2304 O  O   . SER A 1 301 ? 5.10994  -1.35158  -17.66415 1.000 48.80793 ? 301 SER A O   1 
ATOM   2305 C  CB  . SER A 1 301 ? 7.08589  0.66602   -17.16582 1.000 41.55425 ? 301 SER A CB  1 
HETATM 2306 C  C1  . XEK B 2 .   ? 9.36397  0.53162   20.88457  1.000 27.44832 ? 401 XEK A C1  1 
HETATM 2307 C  C2  . XEK B 2 .   ? 10.07187 -0.25510  21.79190  1.000 31.13933 ? 401 XEK A C2  1 
HETATM 2308 C  C3  . XEK B 2 .   ? 11.43256 0.20762   22.31237  1.000 31.23349 ? 401 XEK A C3  1 
HETATM 2309 C  C4  . XEK B 2 .   ? 12.51480 -0.67723  22.33510  1.000 30.47337 ? 401 XEK A C4  1 
HETATM 2310 C  C5  . XEK B 2 .   ? 13.75217 -0.24809  22.80794  1.000 32.66556 ? 401 XEK A C5  1 
HETATM 2311 C  C6  . XEK B 2 .   ? 13.90826 1.05310   23.25330  1.000 33.59385 ? 401 XEK A C6  1 
HETATM 2312 C  C7  . XEK B 2 .   ? 12.83072 1.93377   23.21950  1.000 34.86869 ? 401 XEK A C7  1 
HETATM 2313 C  C8  . XEK B 2 .   ? 12.81323 4.25911   22.71489  1.000 34.83776 ? 401 XEK A C8  1 
HETATM 2314 C  C9  . XEK B 2 .   ? 13.18655 5.56137   23.42297  1.000 38.80574 ? 401 XEK A C9  1 
HETATM 2315 C  C10 . XEK B 2 .   ? 12.37145 5.99195   24.45760  1.000 36.81296 ? 401 XEK A C10 1 
HETATM 2316 C  C11 . XEK B 2 .   ? 12.67992 7.16163   25.13355  1.000 36.65220 ? 401 XEK A C11 1 
HETATM 2317 C  C12 . XEK B 2 .   ? 13.79948 7.90351   24.77601  1.000 34.47227 ? 401 XEK A C12 1 
HETATM 2318 C  C13 . XEK B 2 .   ? 14.61535 7.47193   23.74363  1.000 36.46609 ? 401 XEK A C13 1 
HETATM 2319 C  C14 . XEK B 2 .   ? 14.31359 6.29994   23.06621  1.000 35.34411 ? 401 XEK A C14 1 
HETATM 2320 C  C15 . XEK B 2 .   ? 11.59437 1.50813   22.75760  1.000 31.21378 ? 401 XEK A C15 1 
HETATM 2321 C  C17 . XEK B 2 .   ? 8.30860  -1.88510  21.77632  1.000 34.50349 ? 401 XEK A C17 1 
HETATM 2322 C  C21 . XEK B 2 .   ? 7.63280  -5.14155  25.42563  1.000 42.96321 ? 401 XEK A C21 1 
HETATM 2323 C  C22 . XEK B 2 .   ? 6.73645  -5.57841  23.21910  1.000 43.36153 ? 401 XEK A C22 1 
HETATM 2324 C  C24 . XEK B 2 .   ? 7.38307  0.85140   19.50106  1.000 28.89448 ? 401 XEK A C24 1 
HETATM 2325 C  C25 . XEK B 2 .   ? 6.18205  1.44803   19.84536  1.000 27.60155 ? 401 XEK A C25 1 
HETATM 2326 C  C27 . XEK B 2 .   ? 6.02101  2.24783   17.58521  1.000 29.19308 ? 401 XEK A C27 1 
HETATM 2327 C  C16 . XEK B 2 .   ? 9.54853  -1.46074  22.24404  1.000 33.17397 ? 401 XEK A C16 1 
HETATM 2328 C  C18 . XEK B 2 .   ? 7.72001  -3.22349  22.25228  1.000 37.39426 ? 401 XEK A C18 1 
HETATM 2329 C  C19 . XEK B 2 .   ? 7.00214  -4.09289  21.42839  1.000 37.12697 ? 401 XEK A C19 1 
HETATM 2330 C  C20 . XEK B 2 .   ? 7.90483  -3.61558  23.57884  1.000 39.72326 ? 401 XEK A C20 1 
HETATM 2331 C  C23 . XEK B 2 .   ? 7.65551  -1.06492  20.87269  1.000 31.79832 ? 401 XEK A C23 1 
HETATM 2332 C  C26 . XEK B 2 .   ? 5.49295  2.15802   18.86652  1.000 28.37165 ? 401 XEK A C26 1 
HETATM 2333 C  C28 . XEK B 2 .   ? 7.85681  0.97535   18.20106  1.000 27.49813 ? 401 XEK A C28 1 
HETATM 2334 F  F1  . XEK B 2 .   ? 15.13453 1.43233   23.70606  1.000 33.84787 ? 401 XEK A F1  1 
HETATM 2335 N  N1  . XEK B 2 .   ? 6.53763  -5.23825  21.93899  1.000 39.41795 ? 401 XEK A N1  1 
HETATM 2336 N  N2  . XEK B 2 .   ? 7.41737  -4.77238  24.03518  1.000 47.18090 ? 401 XEK A N2  1 
HETATM 2337 N  N3  . XEK B 2 .   ? 8.17223  0.09048   20.45678  1.000 28.88476 ? 401 XEK A N3  1 
HETATM 2338 N  N4  . XEK B 2 .   ? 7.17787  1.66104   17.28100  1.000 27.88829 ? 401 XEK A N4  1 
HETATM 2339 O  O1  . XEK B 2 .   ? 9.81863  1.60321   20.48415  1.000 25.33526 ? 401 XEK A O1  1 
HETATM 2340 O  O2  . XEK B 2 .   ? 12.96616 3.24674   23.67499  1.000 37.12893 ? 401 XEK A O2  1 
HETATM 2341 O  O3  . XEK B 2 .   ? 6.77936  -3.84187  20.24341  1.000 33.31876 ? 401 XEK A O3  1 
HETATM 2342 O  O4  . XEK B 2 .   ? 6.30043  -6.60475  23.61588  1.000 43.55433 ? 401 XEK A O4  1 
HETATM 2343 CL CL1 . XEK B 2 .   ? 15.17046 -1.32684  22.87699  1.000 31.95962 ? 401 XEK A CL1 1 
HETATM 2344 CL CL2 . XEK B 2 .   ? 15.38715 5.77648   21.74112  1.000 52.91250 ? 401 XEK A CL2 1 
HETATM 2345 H  H1  . XEK B 2 .   ? 12.39091 -1.69475  21.98552  1.000 36.56804 ? 401 XEK A H1  1 
HETATM 2346 H  H2  . XEK B 2 .   ? 13.47394 4.08438   21.87476  1.000 41.80531 ? 401 XEK A H2  1 
HETATM 2347 H  H3  . XEK B 2 .   ? 11.78756 4.29882   22.36948  1.000 41.80531 ? 401 XEK A H3  1 
HETATM 2348 H  H4  . XEK B 2 .   ? 11.49721 5.41692   24.73675  1.000 44.17555 ? 401 XEK A H4  1 
HETATM 2349 H  H5  . XEK B 2 .   ? 12.04582 7.49917   25.94403  1.000 43.98264 ? 401 XEK A H5  1 
HETATM 2350 H  H6  . XEK B 2 .   ? 14.03382 8.81915   25.30477  1.000 41.36672 ? 401 XEK A H6  1 
HETATM 2351 H  H7  . XEK B 2 .   ? 15.48844 8.04917   23.46544  1.000 43.75931 ? 401 XEK A H7  1 
HETATM 2352 H  H8  . XEK B 2 .   ? 10.75563 2.19315   22.74525  1.000 37.45653 ? 401 XEK A H8  1 
HETATM 2353 H  H13 . XEK B 2 .   ? 6.96018  -5.94692  25.69367  1.000 51.55585 ? 401 XEK A H13 1 
HETATM 2354 H  H14 . XEK B 2 .   ? 7.44153  -4.28510  26.06030  1.000 51.55585 ? 401 XEK A H14 1 
HETATM 2355 H  H12 . XEK B 2 .   ? 8.65708  -5.46745  25.55806  1.000 51.55585 ? 401 XEK A H12 1 
HETATM 2356 H  H16 . XEK B 2 .   ? 5.78875  1.36436   20.85095  1.000 33.12186 ? 401 XEK A H16 1 
HETATM 2357 H  H18 . XEK B 2 .   ? 5.48582  2.80170   16.82384  1.000 35.03170 ? 401 XEK A H18 1 
HETATM 2358 H  H9  . XEK B 2 .   ? 10.10067 -2.06428  22.95380  1.000 39.80876 ? 401 XEK A H9  1 
HETATM 2359 H  H11 . XEK B 2 .   ? 8.45447  -2.96900  24.25168  1.000 47.66791 ? 401 XEK A H11 1 
HETATM 2360 H  H15 . XEK B 2 .   ? 6.69035  -1.37321  20.49017  1.000 38.15798 ? 401 XEK A H15 1 
HETATM 2361 H  H17 . XEK B 2 .   ? 4.55094  2.63740   19.10256  1.000 34.04598 ? 401 XEK A H17 1 
HETATM 2362 H  H19 . XEK B 2 .   ? 8.79468  0.50648   17.93000  1.000 32.99776 ? 401 XEK A H19 1 
HETATM 2363 O  O   . HOH C 3 .   ? 6.35251  -7.23879  8.52438   1.000 27.09731 ? 501 HOH A O   1 
HETATM 2364 O  O   . HOH C 3 .   ? 21.13384 -19.08623 15.70135  1.000 31.25433 ? 502 HOH A O   1 
HETATM 2365 O  O   . HOH C 3 .   ? 12.39666 32.21139  -9.07349  1.000 39.67126 ? 503 HOH A O   1 
HETATM 2366 O  O   . HOH C 3 .   ? 23.24516 28.25811  -1.32842  1.000 33.83151 ? 504 HOH A O   1 
HETATM 2367 O  O   . HOH C 3 .   ? 10.64551 0.22907   -3.54981  1.000 27.40433 ? 505 HOH A O   1 
HETATM 2368 O  O   . HOH C 3 .   ? 3.453    5.603     2.649     1.000 31.61615 ? 506 HOH A O   1 
HETATM 2369 O  O   . HOH C 3 .   ? 24.77982 -13.90066 25.57088  1.000 29.47029 ? 507 HOH A O   1 
HETATM 2370 O  O   . HOH C 3 .   ? 10.60372 -22.89969 22.58680  1.000 29.49690 ? 508 HOH A O   1 
HETATM 2371 O  O   . HOH C 3 .   ? 20.55489 10.39818  0.45196   1.000 34.92332 ? 509 HOH A O   1 
HETATM 2372 O  O   . HOH C 3 .   ? 18.24256 32.54662  -11.62698 1.000 39.03625 ? 510 HOH A O   1 
HETATM 2373 O  O   . HOH C 3 .   ? 12.86545 24.70888  -19.28382 1.000 29.67768 ? 511 HOH A O   1 
HETATM 2374 O  O   . HOH C 3 .   ? 14.78998 28.18019  -12.68215 1.000 32.99570 ? 512 HOH A O   1 
HETATM 2375 O  O   . HOH C 3 .   ? 17.85783 5.08900   -14.20683 1.000 35.97654 ? 513 HOH A O   1 
HETATM 2376 O  O   . HOH C 3 .   ? -0.25394 5.42158   -14.46759 1.000 37.31190 ? 514 HOH A O   1 
HETATM 2377 O  O   . HOH C 3 .   ? 10.38146 21.12133  -0.81128  1.000 28.80625 ? 515 HOH A O   1 
HETATM 2378 O  O   . HOH C 3 .   ? 23.93323 11.19380  -18.39579 1.000 29.69087 ? 516 HOH A O   1 
HETATM 2379 O  O   . HOH C 3 .   ? -1.82063 5.28472   -18.95975 1.000 36.57975 ? 517 HOH A O   1 
HETATM 2380 O  O   . HOH C 3 .   ? 3.66325  -6.55205  21.64126  1.000 37.64812 ? 518 HOH A O   1 
HETATM 2381 O  O   . HOH C 3 .   ? 14.68252 19.90748  -22.66229 1.000 26.08760 ? 519 HOH A O   1 
HETATM 2382 O  O   . HOH C 3 .   ? 5.61062  -16.69620 1.51298   1.000 27.31058 ? 520 HOH A O   1 
HETATM 2383 O  O   . HOH C 3 .   ? 25.96456 -3.03071  14.24493  1.000 31.53590 ? 521 HOH A O   1 
HETATM 2384 O  O   . HOH C 3 .   ? 13.06267 -26.58298 22.36567  1.000 29.48248 ? 522 HOH A O   1 
HETATM 2385 O  O   . HOH C 3 .   ? 27.75459 23.30275  -13.48330 1.000 29.17448 ? 523 HOH A O   1 
HETATM 2386 O  O   . HOH C 3 .   ? 23.05221 24.46577  -18.39613 1.000 25.13199 ? 524 HOH A O   1 
HETATM 2387 O  O   . HOH C 3 .   ? 7.95596  4.52491   -3.62862  1.000 31.58853 ? 525 HOH A O   1 
HETATM 2388 O  O   . HOH C 3 .   ? 22.45376 -1.80799  25.91248  1.000 34.55933 ? 526 HOH A O   1 
HETATM 2389 O  O   . HOH C 3 .   ? 23.93516 -7.33364  33.57648  1.000 33.99092 ? 527 HOH A O   1 
HETATM 2390 O  O   . HOH C 3 .   ? -3.01591 11.44839  -17.33555 1.000 37.89416 ? 528 HOH A O   1 
HETATM 2391 O  O   . HOH C 3 .   ? 20.25493 11.59211  -2.64158  1.000 35.86101 ? 529 HOH A O   1 
HETATM 2392 O  O   . HOH C 3 .   ? 2.68819  10.57096  -21.11953 1.000 38.29691 ? 530 HOH A O   1 
HETATM 2393 O  O   . HOH C 3 .   ? 17.24285 -12.53411 30.71926  1.000 37.80806 ? 531 HOH A O   1 
HETATM 2394 O  O   . HOH C 3 .   ? 10.12975 7.66171   5.30293   1.000 23.44974 ? 532 HOH A O   1 
HETATM 2395 O  O   . HOH C 3 .   ? 9.01348  -30.89505 16.60762  1.000 40.48376 ? 533 HOH A O   1 
HETATM 2396 O  O   . HOH C 3 .   ? -2.60871 18.18387  -8.92122  1.000 30.70085 ? 534 HOH A O   1 
HETATM 2397 O  O   . HOH C 3 .   ? 18.02132 -6.44331  -4.03000  1.000 34.10761 ? 535 HOH A O   1 
HETATM 2398 O  O   . HOH C 3 .   ? 27.41986 18.02557  -7.62101  1.000 35.91770 ? 536 HOH A O   1 
HETATM 2399 O  O   . HOH C 3 .   ? 22.84430 -13.55044 33.07960  1.000 29.06514 ? 537 HOH A O   1 
HETATM 2400 O  O   . HOH C 3 .   ? 6.10344  2.73511   -7.93470  1.000 34.89141 ? 538 HOH A O   1 
HETATM 2401 O  O   . HOH C 3 .   ? 19.35299 -6.69604  5.35696   1.000 25.18290 ? 539 HOH A O   1 
HETATM 2402 O  O   . HOH C 3 .   ? 3.33523  -8.02789  18.43676  1.000 26.30544 ? 540 HOH A O   1 
HETATM 2403 O  O   . HOH C 3 .   ? 14.26417 1.03007   -3.53654  1.000 31.87226 ? 541 HOH A O   1 
HETATM 2404 O  O   . HOH C 3 .   ? 0.43864  -0.13607  11.83846  1.000 32.49011 ? 542 HOH A O   1 
HETATM 2405 O  O   . HOH C 3 .   ? 22.81730 2.41967   4.18775   1.000 31.86637 ? 543 HOH A O   1 
HETATM 2406 O  O   . HOH C 3 .   ? 7.36425  21.18746  -0.94661  1.000 32.30240 ? 544 HOH A O   1 
HETATM 2407 O  O   . HOH C 3 .   ? 7.56611  -22.45619 20.58615  1.000 29.41399 ? 545 HOH A O   1 
HETATM 2408 O  O   . HOH C 3 .   ? 16.85949 7.89519   -4.53421  1.000 26.42972 ? 546 HOH A O   1 
HETATM 2409 O  O   . HOH C 3 .   ? 17.29331 -18.12929 7.29423   1.000 28.81975 ? 547 HOH A O   1 
HETATM 2410 O  O   . HOH C 3 .   ? 21.07324 14.42420  6.37252   1.000 33.22038 ? 548 HOH A O   1 
HETATM 2411 O  O   . HOH C 3 .   ? 23.83020 14.09272  -2.88643  1.000 32.30875 ? 549 HOH A O   1 
HETATM 2412 O  O   . HOH C 3 .   ? 5.95683  -16.74809 28.30827  1.000 40.92677 ? 550 HOH A O   1 
HETATM 2413 O  O   . HOH C 3 .   ? 8.767    -24.102   25.310    1.000 26.22184 ? 551 HOH A O   1 
HETATM 2414 O  O   . HOH C 3 .   ? 4.63031  -16.76293 20.78225  1.000 29.12803 ? 552 HOH A O   1 
HETATM 2415 O  O   . HOH C 3 .   ? 13.88713 -23.76559 2.94444   1.000 38.40067 ? 553 HOH A O   1 
HETATM 2416 O  O   . HOH C 3 .   ? 3.506    23.664    -19.625   1.000 33.97108 ? 554 HOH A O   1 
HETATM 2417 O  O   . HOH C 3 .   ? 21.07145 -12.32154 9.93401   1.000 26.55304 ? 555 HOH A O   1 
HETATM 2418 O  O   . HOH C 3 .   ? 5.26210  3.66847   -5.02545  1.000 30.58396 ? 556 HOH A O   1 
HETATM 2419 O  O   . HOH C 3 .   ? 16.82014 3.40279   11.42975  1.000 19.71629 ? 557 HOH A O   1 
HETATM 2420 O  O   . HOH C 3 .   ? 21.72277 -18.43753 26.59625  1.000 30.72373 ? 558 HOH A O   1 
HETATM 2421 O  O   . HOH C 3 .   ? 16.33791 -4.77610  19.66186  1.000 20.40235 ? 559 HOH A O   1 
HETATM 2422 O  O   . HOH C 3 .   ? 29.38382 16.23124  -14.53919 1.000 35.68435 ? 560 HOH A O   1 
HETATM 2423 O  O   . HOH C 3 .   ? 9.62309  11.53071  -5.16595  1.000 22.46666 ? 561 HOH A O   1 
HETATM 2424 O  O   . HOH C 3 .   ? 11.27377 23.52398  -17.66590 1.000 32.41154 ? 562 HOH A O   1 
HETATM 2425 O  O   . HOH C 3 .   ? 24.16127 2.79397   15.26878  1.000 24.75012 ? 563 HOH A O   1 
HETATM 2426 O  O   . HOH C 3 .   ? -3.717   -11.091   2.707     1.000 27.55562 ? 564 HOH A O   1 
HETATM 2427 O  O   . HOH C 3 .   ? 27.72464 -10.28243 11.76784  1.000 33.31119 ? 565 HOH A O   1 
HETATM 2428 O  O   . HOH C 3 .   ? 12.55491 -29.34750 22.03207  1.000 32.20560 ? 566 HOH A O   1 
HETATM 2429 O  O   . HOH C 3 .   ? 15.16352 7.72027   -14.98109 1.000 30.09153 ? 567 HOH A O   1 
HETATM 2430 O  O   . HOH C 3 .   ? 21.11038 23.42643  -19.87044 1.000 30.32831 ? 568 HOH A O   1 
HETATM 2431 O  O   . HOH C 3 .   ? 25.17589 17.32846  -15.51512 1.000 32.87342 ? 569 HOH A O   1 
HETATM 2432 O  O   . HOH C 3 .   ? 16.18844 30.09885  -21.41926 1.000 34.02806 ? 570 HOH A O   1 
HETATM 2433 O  O   . HOH C 3 .   ? 24.67278 -15.23730 20.76367  1.000 33.00793 ? 571 HOH A O   1 
HETATM 2434 O  O   . HOH C 3 .   ? 19.17807 13.38590  -4.36314  1.000 28.50398 ? 572 HOH A O   1 
HETATM 2435 O  O   . HOH C 3 .   ? 13.30766 1.69832   -5.75926  1.000 31.53626 ? 573 HOH A O   1 
HETATM 2436 O  O   . HOH C 3 .   ? 4.44252  28.62368  -8.91722  1.000 43.19945 ? 574 HOH A O   1 
HETATM 2437 O  O   . HOH C 3 .   ? 10.31013 26.36134  -0.98537  1.000 34.46405 ? 575 HOH A O   1 
HETATM 2438 O  O   . HOH C 3 .   ? 22.41553 10.37393  3.90404   1.000 29.50489 ? 576 HOH A O   1 
HETATM 2439 O  O   . HOH C 3 .   ? 27.37785 4.14295   0.87335   1.000 53.14012 ? 577 HOH A O   1 
HETATM 2440 O  O   . HOH C 3 .   ? 15.17651 -4.21391  -0.41923  1.000 30.04956 ? 578 HOH A O   1 
HETATM 2441 O  O   . HOH C 3 .   ? 22.21275 -0.98198  23.22774  1.000 28.27864 ? 579 HOH A O   1 
HETATM 2442 O  O   . HOH C 3 .   ? 22.79603 11.19086  7.69876   1.000 35.07374 ? 580 HOH A O   1 
HETATM 2443 O  O   . HOH C 3 .   ? 12.79630 23.66767  1.59794   1.000 36.79904 ? 581 HOH A O   1 
HETATM 2444 O  O   . HOH C 3 .   ? 23.75516 -1.55178  15.11972  1.000 23.27220 ? 582 HOH A O   1 
HETATM 2445 O  O   . HOH C 3 .   ? 23.41694 0.05074   17.43233  1.000 23.72233 ? 583 HOH A O   1 
HETATM 2446 O  O   . HOH C 3 .   ? 20.94222 11.65935  -18.15533 1.000 27.74954 ? 584 HOH A O   1 
HETATM 2447 O  O   . HOH C 3 .   ? 1.899    2.989     0.313     1.000 30.23117 ? 585 HOH A O   1 
HETATM 2448 O  O   . HOH C 3 .   ? 8.32532  26.44764  -12.39366 1.000 35.64753 ? 586 HOH A O   1 
HETATM 2449 O  O   . HOH C 3 .   ? -2.40774 21.13243  -11.36833 1.000 37.04813 ? 587 HOH A O   1 
HETATM 2450 O  O   . HOH C 3 .   ? 19.10983 -23.64429 25.38324  1.000 36.03691 ? 588 HOH A O   1 
HETATM 2451 O  O   . HOH C 3 .   ? 9.63220  -16.80809 -4.51104  1.000 34.61101 ? 589 HOH A O   1 
HETATM 2452 O  O   . HOH C 3 .   ? 13.73885 12.43977  11.46539  1.000 32.95628 ? 590 HOH A O   1 
HETATM 2453 O  O   . HOH C 3 .   ? 17.29473 29.16899  -13.83323 1.000 30.67371 ? 591 HOH A O   1 
HETATM 2454 O  O   . HOH C 3 .   ? 12.93210 18.00469  -26.57293 1.000 37.64378 ? 592 HOH A O   1 
HETATM 2455 O  O   . HOH C 3 .   ? 25.94026 21.90268  -15.45966 1.000 32.25100 ? 593 HOH A O   1 
HETATM 2456 O  O   . HOH C 3 .   ? 25.27450 -8.36715  19.77719  1.000 25.54403 ? 594 HOH A O   1 
HETATM 2457 O  O   . HOH C 3 .   ? 16.08668 4.49567   -8.76159  1.000 28.19268 ? 595 HOH A O   1 
HETATM 2458 O  O   . HOH C 3 .   ? 26.37478 -10.83917 19.27694  1.000 31.94146 ? 596 HOH A O   1 
HETATM 2459 O  O   . HOH C 3 .   ? 10.88888 -25.23568 21.67508  1.000 26.63680 ? 597 HOH A O   1 
HETATM 2460 O  O   . HOH C 3 .   ? 27.161   -9.876    16.754    1.000 27.31798 ? 598 HOH A O   1 
HETATM 2461 O  O   . HOH C 3 .   ? 1.86182  -16.04767 12.33481  1.000 35.42121 ? 599 HOH A O   1 
HETATM 2462 O  O   . HOH C 3 .   ? 24.87136 14.73395  -18.31793 1.000 33.43359 ? 600 HOH A O   1 
HETATM 2463 O  O   . HOH C 3 .   ? 14.31488 12.05442  -25.92362 1.000 31.31261 ? 601 HOH A O   1 
HETATM 2464 O  O   . HOH C 3 .   ? 23.35212 -4.88613  0.49401   1.000 31.18095 ? 602 HOH A O   1 
HETATM 2465 O  O   . HOH C 3 .   ? 26.00387 -6.65348  21.80741  1.000 36.55681 ? 603 HOH A O   1 
HETATM 2466 O  O   . HOH C 3 .   ? 22.71487 -1.06905  19.70419  1.000 26.17106 ? 604 HOH A O   1 
HETATM 2467 O  O   . HOH C 3 .   ? 30.160   20.332    -9.226    1.000 39.19594 ? 605 HOH A O   1 
HETATM 2468 O  O   . HOH C 3 .   ? 4.15871  -21.45922 6.59461   1.000 32.59942 ? 606 HOH A O   1 
HETATM 2469 O  O   . HOH C 3 .   ? 1.453    2.717     20.225    1.000 36.41392 ? 607 HOH A O   1 
HETATM 2470 O  O   . HOH C 3 .   ? -2.41967 -0.70903  11.49634  1.000 40.12729 ? 608 HOH A O   1 
HETATM 2471 O  O   . HOH C 3 .   ? 3.16990  -19.04542 21.61186  1.000 30.42620 ? 609 HOH A O   1 
HETATM 2472 O  O   . HOH C 3 .   ? 19.22056 15.13166  -19.60803 1.000 37.91122 ? 610 HOH A O   1 
HETATM 2473 O  O   . HOH C 3 .   ? 21.07818 10.28275  11.67132  1.000 25.65021 ? 611 HOH A O   1 
HETATM 2474 O  O   . HOH C 3 .   ? 23.19247 -3.16789  32.98501  1.000 43.80870 ? 612 HOH A O   1 
HETATM 2475 O  O   . HOH C 3 .   ? 25.08868 2.36558   6.02669   1.000 34.85926 ? 613 HOH A O   1 
HETATM 2476 O  O   . HOH C 3 .   ? 27.890   -10.682   7.651     1.000 38.76463 ? 614 HOH A O   1 
HETATM 2477 O  O   . HOH C 3 .   ? -0.84744 20.98934  -16.21948 1.000 39.45004 ? 615 HOH A O   1 
HETATM 2478 O  O   . HOH C 3 .   ? -1.39849 5.31834   -1.76305  1.000 33.82762 ? 616 HOH A O   1 
HETATM 2479 O  O   . HOH C 3 .   ? 2.04033  12.41526  -5.74067  1.000 28.74269 ? 617 HOH A O   1 
HETATM 2480 O  O   . HOH C 3 .   ? 8.45532  30.34718  -18.19629 1.000 35.54929 ? 618 HOH A O   1 
HETATM 2481 O  O   . HOH C 3 .   ? 29.06607 15.44744  -10.17121 1.000 36.50073 ? 619 HOH A O   1 
HETATM 2482 O  O   . HOH C 3 .   ? 7.388    14.684    20.730    1.000 34.26471 ? 620 HOH A O   1 
HETATM 2483 O  O   . HOH C 3 .   ? 20.73239 18.14475  -18.70452 1.000 30.84505 ? 621 HOH A O   1 
HETATM 2484 O  O   . HOH C 3 .   ? 18.44972 -15.05957 -3.57671  1.000 39.31935 ? 622 HOH A O   1 
HETATM 2485 O  O   . HOH C 3 .   ? 21.93067 -22.17684 21.09535  1.000 27.07622 ? 623 HOH A O   1 
HETATM 2486 O  O   . HOH C 3 .   ? 15.943   -25.450   26.182    1.000 27.88355 ? 624 HOH A O   1 
HETATM 2487 O  O   . HOH C 3 .   ? 24.57594 -5.03879  25.58334  1.000 29.53870 ? 625 HOH A O   1 
HETATM 2488 O  O   . HOH C 3 .   ? 16.887   -27.665   23.057    1.000 34.60946 ? 626 HOH A O   1 
HETATM 2489 O  O   . HOH C 3 .   ? 11.07925 -23.05987 -0.14813  1.000 34.22442 ? 627 HOH A O   1 
HETATM 2490 O  O   . HOH C 3 .   ? 0.47463  -16.30757 15.68927  1.000 38.51471 ? 628 HOH A O   1 
HETATM 2491 O  O   . HOH C 3 .   ? 1.78728  27.54635  -16.60596 1.000 40.38507 ? 629 HOH A O   1 
HETATM 2492 O  O   . HOH C 3 .   ? 28.61748 -9.75438  29.33052  1.000 33.01316 ? 630 HOH A O   1 
HETATM 2493 O  O   . HOH C 3 .   ? 16.96745 -17.78835 -1.18253  1.000 32.77013 ? 631 HOH A O   1 
HETATM 2494 O  O   . HOH C 3 .   ? 16.056   11.465    23.185    1.000 35.68657 ? 632 HOH A O   1 
HETATM 2495 O  O   . HOH C 3 .   ? 9.32263  29.92548  -1.33248  1.000 37.65791 ? 633 HOH A O   1 
HETATM 2496 O  O   . HOH C 3 .   ? 27.15383 27.93466  -9.31039  1.000 37.64039 ? 634 HOH A O   1 
HETATM 2497 O  O   . HOH C 3 .   ? 17.204   -24.924   6.035     1.000 35.52553 ? 635 HOH A O   1 
HETATM 2498 O  O   . HOH C 3 .   ? 13.70033 13.53751  14.20813  1.000 37.58358 ? 636 HOH A O   1 
HETATM 2499 O  O   . HOH C 3 .   ? 21.90902 -21.65158 16.95500  1.000 33.65317 ? 637 HOH A O   1 
HETATM 2500 O  O   . HOH C 3 .   ? 16.41717 -3.79512  -2.65676  1.000 35.50869 ? 638 HOH A O   1 
HETATM 2501 O  O   . HOH C 3 .   ? 21.83041 -19.04672 13.43842  1.000 37.96837 ? 639 HOH A O   1 
HETATM 2502 O  O   . HOH C 3 .   ? 25.12598 -20.00486 21.69488  1.000 40.07990 ? 640 HOH A O   1 
HETATM 2503 O  O   . HOH C 3 .   ? 7.904    -27.530   21.131    1.000 20.29407 ? 641 HOH A O   1 
HETATM 2504 O  O   . HOH C 3 .   ? 19.46763 8.91748   -3.60062  1.000 33.83528 ? 642 HOH A O   1 
HETATM 2505 O  O   . HOH C 3 .   ? 6.77436  29.45153  -19.46233 1.000 42.57343 ? 643 HOH A O   1 
HETATM 2506 O  O   . HOH C 3 .   ? 22.26558 -13.80850 8.02661   1.000 37.57389 ? 644 HOH A O   1 
HETATM 2507 O  O   . HOH C 3 .   ? -3.87963 11.62308  -7.77504  1.000 46.11909 ? 645 HOH A O   1 
HETATM 2508 O  O   . HOH C 3 .   ? 22.73868 13.32588  4.39234   1.000 35.71713 ? 646 HOH A O   1 
HETATM 2509 O  O   . HOH C 3 .   ? 24.07686 -16.77719 25.26026  1.000 32.79343 ? 647 HOH A O   1 
HETATM 2510 O  O   . HOH C 3 .   ? 24.65055 8.02803   10.41943  1.000 35.83622 ? 648 HOH A O   1 
HETATM 2511 O  O   . HOH C 3 .   ? 18.40265 -25.70906 26.82160  1.000 33.00106 ? 649 HOH A O   1 
HETATM 2512 O  O   . HOH C 3 .   ? 15.26557 -4.96153  -5.13632  1.000 36.81618 ? 650 HOH A O   1 
HETATM 2513 O  O   . HOH C 3 .   ? 11.68897 14.63439  13.63325  1.000 37.84169 ? 651 HOH A O   1 
HETATM 2514 O  O   . HOH C 3 .   ? 14.757   -27.434   24.402    1.000 31.07893 ? 652 HOH A O   1 
HETATM 2515 O  O   . HOH C 3 .   ? 8.54399  23.07887  -21.80010 1.000 34.67546 ? 653 HOH A O   1 
HETATM 2516 O  O   . HOH C 3 .   ? 26.53304 19.45463  -15.67584 1.000 36.30449 ? 654 HOH A O   1 
HETATM 2517 O  O   . HOH C 3 .   ? -5.28578 11.79974  -5.12809  1.000 47.65760 ? 655 HOH A O   1 
HETATM 2518 O  O   . HOH C 3 .   ? 6.63052  23.70608  -1.88739  1.000 43.71581 ? 656 HOH A O   1 
HETATM 2519 O  O   . HOH C 3 .   ? 23.09794 17.71252  2.42657   1.000 40.38815 ? 657 HOH A O   1 
HETATM 2520 O  O   . HOH C 3 .   ? 23.15598 10.15601  10.14629  1.000 34.67110 ? 658 HOH A O   1 
HETATM 2521 O  O   . HOH C 3 .   ? 25.49892 23.14090  -18.04927 1.000 35.62124 ? 659 HOH A O   1 
HETATM 2522 O  O   . HOH C 3 .   ? 16.862   -29.290   21.201    1.000 39.41535 ? 660 HOH A O   1 
HETATM 2523 O  O   . HOH C 3 .   ? -3.50282 22.66919  -12.99498 1.000 46.49334 ? 661 HOH A O   1 
HETATM 2524 O  O   . HOH C 3 .   ? 26.14326 0.72963   17.63181  1.000 32.53465 ? 662 HOH A O   1 
HETATM 2525 O  O   . HOH C 3 .   ? -0.469   20.762    -20.903   1.000 39.22768 ? 663 HOH A O   1 
HETATM 2526 O  O   . HOH C 3 .   ? 8.21309  31.05244  -15.84208 1.000 38.01340 ? 664 HOH A O   1 
HETATM 2527 O  O   . HOH C 3 .   ? 10.94452 23.98302  0.14093   1.000 32.93728 ? 665 HOH A O   1 
# 
