data_9BO1
# 
_entry.id   9BO1 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BO1         pdb_00009bo1 10.2210/pdb9bo1/pdb 
WWPDB D_1000282928 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-12 ? 
2 'Structure model' 1 1 2025-03-12 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
_pdbx_audit_revision_category.ordinal             1 
_pdbx_audit_revision_category.revision_ordinal    2 
_pdbx_audit_revision_category.data_content_type   'Structure model' 
_pdbx_audit_revision_category.category            citation 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
5 2 'Structure model' '_citation.title'                   
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BO1 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-03 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              karen.anderson@yale.edu 
_pdbx_contact_author.name_first         Karen 
_pdbx_contact_author.name_last          Anderson 
_pdbx_contact_author.name_mi            S 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-3433-0780 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Papini, C.'      1 0000-0002-6098-4959 
'Zhang, C.H.'     2 ?                   
'Jorgensen, W.L.' 3 ?                   
'Anderson, K.S.'  4 0000-0003-3433-0780 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Acs Bio Med Chem Au' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2694-2437 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            5 
_citation.language                  ? 
_citation.page_first                215 
_citation.page_last                 226 
_citation.title                     
'Exploring Possible Drug-Resistant Variants of SARS-CoV-2 Main Protease (M pro ) with Noncovalent Preclinical Candidate, Mpro61.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acsbiomedchemau.4c00109 
_citation.pdbx_database_id_PubMed   39990941 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Kenneson, J.R.'  1 ? 
primary 'Papini, C.'      2 ? 
primary 'Tang, S.'        3 ? 
primary 'Huynh, K.'       4 ? 
primary 'Zhang, C.H.'     5 ? 
primary 'Jorgensen, W.L.' 6 ? 
primary 'Anderson, K.S.'  7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '3C-like proteinase nsp5' 33837.602 2   3.4.22.69 ? ? ? 
2 non-polymer syn 
;(5P)-5-[(1P,3M,3'P)-3-{3-chloro-5-[(2-chlorophenyl)methoxy]-4-fluorophenyl}-2-oxo-2H-[1,3'-bipyridin]-5-yl]-1-methylpyrimidine-2,4(1H,3H)-dione
;
565.379   1   ?         ? ? ? 
3 water       nat water 18.015    347 ?         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '3CL-PRO,3CLp,Main protease,Mpro,Non-structural protein 5,nsp5,SARS coronavirus main proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQIAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQIAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 
;(5P)-5-[(1P,3M,3'P)-3-{3-chloro-5-[(2-chlorophenyl)methoxy]-4-fluorophenyl}-2-oxo-2H-[1,3'-bipyridin]-5-yl]-1-methylpyrimidine-2,4(1H,3H)-dione
;
XEK 
3 water HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   GLY n 
1 3   PHE n 
1 4   ARG n 
1 5   LYS n 
1 6   MET n 
1 7   ALA n 
1 8   PHE n 
1 9   PRO n 
1 10  SER n 
1 11  GLY n 
1 12  LYS n 
1 13  VAL n 
1 14  GLU n 
1 15  GLY n 
1 16  CYS n 
1 17  MET n 
1 18  VAL n 
1 19  GLN n 
1 20  VAL n 
1 21  THR n 
1 22  CYS n 
1 23  GLY n 
1 24  THR n 
1 25  THR n 
1 26  THR n 
1 27  LEU n 
1 28  ASN n 
1 29  GLY n 
1 30  LEU n 
1 31  TRP n 
1 32  LEU n 
1 33  ASP n 
1 34  ASP n 
1 35  VAL n 
1 36  VAL n 
1 37  TYR n 
1 38  CYS n 
1 39  PRO n 
1 40  ARG n 
1 41  HIS n 
1 42  VAL n 
1 43  ILE n 
1 44  CYS n 
1 45  THR n 
1 46  SER n 
1 47  GLU n 
1 48  ASP n 
1 49  MET n 
1 50  LEU n 
1 51  ASN n 
1 52  PRO n 
1 53  ASN n 
1 54  TYR n 
1 55  GLU n 
1 56  ASP n 
1 57  LEU n 
1 58  LEU n 
1 59  ILE n 
1 60  ARG n 
1 61  LYS n 
1 62  SER n 
1 63  ASN n 
1 64  HIS n 
1 65  ASN n 
1 66  PHE n 
1 67  LEU n 
1 68  VAL n 
1 69  GLN n 
1 70  ALA n 
1 71  GLY n 
1 72  ASN n 
1 73  VAL n 
1 74  GLN n 
1 75  LEU n 
1 76  ARG n 
1 77  VAL n 
1 78  ILE n 
1 79  GLY n 
1 80  HIS n 
1 81  SER n 
1 82  MET n 
1 83  GLN n 
1 84  ASN n 
1 85  CYS n 
1 86  VAL n 
1 87  LEU n 
1 88  LYS n 
1 89  LEU n 
1 90  LYS n 
1 91  VAL n 
1 92  ASP n 
1 93  THR n 
1 94  ALA n 
1 95  ASN n 
1 96  PRO n 
1 97  LYS n 
1 98  THR n 
1 99  PRO n 
1 100 LYS n 
1 101 TYR n 
1 102 LYS n 
1 103 PHE n 
1 104 VAL n 
1 105 ARG n 
1 106 ILE n 
1 107 GLN n 
1 108 PRO n 
1 109 GLY n 
1 110 GLN n 
1 111 THR n 
1 112 PHE n 
1 113 SER n 
1 114 VAL n 
1 115 LEU n 
1 116 ALA n 
1 117 CYS n 
1 118 TYR n 
1 119 ASN n 
1 120 GLY n 
1 121 SER n 
1 122 PRO n 
1 123 SER n 
1 124 GLY n 
1 125 VAL n 
1 126 TYR n 
1 127 GLN n 
1 128 CYS n 
1 129 ALA n 
1 130 MET n 
1 131 ARG n 
1 132 PRO n 
1 133 ASN n 
1 134 PHE n 
1 135 THR n 
1 136 ILE n 
1 137 LYS n 
1 138 GLY n 
1 139 SER n 
1 140 PHE n 
1 141 LEU n 
1 142 ASN n 
1 143 GLY n 
1 144 SER n 
1 145 CYS n 
1 146 GLY n 
1 147 SER n 
1 148 VAL n 
1 149 GLY n 
1 150 PHE n 
1 151 ASN n 
1 152 ILE n 
1 153 ASP n 
1 154 TYR n 
1 155 ASP n 
1 156 CYS n 
1 157 VAL n 
1 158 SER n 
1 159 PHE n 
1 160 CYS n 
1 161 TYR n 
1 162 MET n 
1 163 HIS n 
1 164 HIS n 
1 165 MET n 
1 166 GLU n 
1 167 LEU n 
1 168 PRO n 
1 169 THR n 
1 170 GLY n 
1 171 VAL n 
1 172 HIS n 
1 173 ALA n 
1 174 GLY n 
1 175 THR n 
1 176 ASP n 
1 177 LEU n 
1 178 GLU n 
1 179 GLY n 
1 180 ASN n 
1 181 PHE n 
1 182 TYR n 
1 183 GLY n 
1 184 PRO n 
1 185 PHE n 
1 186 VAL n 
1 187 ASP n 
1 188 ARG n 
1 189 GLN n 
1 190 ILE n 
1 191 ALA n 
1 192 GLN n 
1 193 ALA n 
1 194 ALA n 
1 195 GLY n 
1 196 THR n 
1 197 ASP n 
1 198 THR n 
1 199 THR n 
1 200 ILE n 
1 201 THR n 
1 202 VAL n 
1 203 ASN n 
1 204 VAL n 
1 205 LEU n 
1 206 ALA n 
1 207 TRP n 
1 208 LEU n 
1 209 TYR n 
1 210 ALA n 
1 211 ALA n 
1 212 VAL n 
1 213 ILE n 
1 214 ASN n 
1 215 GLY n 
1 216 ASP n 
1 217 ARG n 
1 218 TRP n 
1 219 PHE n 
1 220 LEU n 
1 221 ASN n 
1 222 ARG n 
1 223 PHE n 
1 224 THR n 
1 225 THR n 
1 226 THR n 
1 227 LEU n 
1 228 ASN n 
1 229 ASP n 
1 230 PHE n 
1 231 ASN n 
1 232 LEU n 
1 233 VAL n 
1 234 ALA n 
1 235 MET n 
1 236 LYS n 
1 237 TYR n 
1 238 ASN n 
1 239 TYR n 
1 240 GLU n 
1 241 PRO n 
1 242 LEU n 
1 243 THR n 
1 244 GLN n 
1 245 ASP n 
1 246 HIS n 
1 247 VAL n 
1 248 ASP n 
1 249 ILE n 
1 250 LEU n 
1 251 GLY n 
1 252 PRO n 
1 253 LEU n 
1 254 SER n 
1 255 ALA n 
1 256 GLN n 
1 257 THR n 
1 258 GLY n 
1 259 ILE n 
1 260 ALA n 
1 261 VAL n 
1 262 LEU n 
1 263 ASP n 
1 264 MET n 
1 265 CYS n 
1 266 ALA n 
1 267 SER n 
1 268 LEU n 
1 269 LYS n 
1 270 GLU n 
1 271 LEU n 
1 272 LEU n 
1 273 GLN n 
1 274 ASN n 
1 275 GLY n 
1 276 MET n 
1 277 ASN n 
1 278 GLY n 
1 279 ARG n 
1 280 THR n 
1 281 ILE n 
1 282 LEU n 
1 283 GLY n 
1 284 SER n 
1 285 ALA n 
1 286 LEU n 
1 287 LEU n 
1 288 GLU n 
1 289 ASP n 
1 290 GLU n 
1 291 PHE n 
1 292 THR n 
1 293 PRO n 
1 294 PHE n 
1 295 ASP n 
1 296 VAL n 
1 297 VAL n 
1 298 ARG n 
1 299 GLN n 
1 300 CYS n 
1 301 SER n 
1 302 GLY n 
1 303 VAL n 
1 304 THR n 
1 305 PHE n 
1 306 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   306 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'rep, 1a-1b' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2'          89.093  
ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1'      175.209 
ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'         132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'          133.103 
CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'        121.158 
GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'        146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'          147.129 
GLY 'peptide linking'   y GLYCINE ? 'C2 H5 N O2'          75.067  
HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1'      156.162 
HOH non-polymer         . WATER ? 'H2 O'                18.015  
ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'         131.173 
LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'         131.173 
LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1'      147.195 
MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'       149.211 
PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'         165.189 
PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2'          115.130 
SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3'          105.093 
THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3'          119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'       204.225 
TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'         181.189 
VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2'         117.146 
XEK non-polymer         . 
;(5P)-5-[(1P,3M,3'P)-3-{3-chloro-5-[(2-chlorophenyl)methoxy]-4-fluorophenyl}-2-oxo-2H-[1,3'-bipyridin]-5-yl]-1-methylpyrimidine-2,4(1H,3H)-dione
;
? 'C28 H19 Cl2 F N4 O4' 565.379 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   1   1   SER SER A . n 
A 1 2   GLY 2   2   2   GLY GLY A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   ARG 4   4   4   ARG ARG A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   MET 6   6   6   MET MET A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   PRO 9   9   9   PRO PRO A . n 
A 1 10  SER 10  10  10  SER SER A . n 
A 1 11  GLY 11  11  11  GLY GLY A . n 
A 1 12  LYS 12  12  12  LYS LYS A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  GLY 15  15  15  GLY GLY A . n 
A 1 16  CYS 16  16  16  CYS CYS A . n 
A 1 17  MET 17  17  17  MET MET A . n 
A 1 18  VAL 18  18  18  VAL VAL A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  THR 21  21  21  THR THR A . n 
A 1 22  CYS 22  22  22  CYS CYS A . n 
A 1 23  GLY 23  23  23  GLY GLY A . n 
A 1 24  THR 24  24  24  THR THR A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  THR 26  26  26  THR THR A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  ASN 28  28  28  ASN ASN A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  TRP 31  31  31  TRP TRP A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  ASP 33  33  33  ASP ASP A . n 
A 1 34  ASP 34  34  34  ASP ASP A . n 
A 1 35  VAL 35  35  35  VAL VAL A . n 
A 1 36  VAL 36  36  36  VAL VAL A . n 
A 1 37  TYR 37  37  37  TYR TYR A . n 
A 1 38  CYS 38  38  38  CYS CYS A . n 
A 1 39  PRO 39  39  39  PRO PRO A . n 
A 1 40  ARG 40  40  40  ARG ARG A . n 
A 1 41  HIS 41  41  41  HIS HIS A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  ILE 43  43  43  ILE ILE A . n 
A 1 44  CYS 44  44  44  CYS CYS A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  SER 46  46  46  SER SER A . n 
A 1 47  GLU 47  47  47  GLU GLU A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  MET 49  49  49  MET MET A . n 
A 1 50  LEU 50  50  50  LEU LEU A . n 
A 1 51  ASN 51  51  51  ASN ASN A . n 
A 1 52  PRO 52  52  52  PRO PRO A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  TYR 54  54  54  TYR TYR A . n 
A 1 55  GLU 55  55  55  GLU GLU A . n 
A 1 56  ASP 56  56  56  ASP ASP A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  ILE 59  59  59  ILE ILE A . n 
A 1 60  ARG 60  60  60  ARG ARG A . n 
A 1 61  LYS 61  61  61  LYS LYS A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  ASN 63  63  63  ASN ASN A . n 
A 1 64  HIS 64  64  64  HIS HIS A . n 
A 1 65  ASN 65  65  65  ASN ASN A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  GLN 69  69  69  GLN GLN A . n 
A 1 70  ALA 70  70  70  ALA ALA A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  ASN 72  72  72  ASN ASN A . n 
A 1 73  VAL 73  73  73  VAL VAL A . n 
A 1 74  GLN 74  74  74  GLN GLN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  ARG 76  76  76  ARG ARG A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  GLY 79  79  79  GLY GLY A . n 
A 1 80  HIS 80  80  80  HIS HIS A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  MET 82  82  82  MET MET A . n 
A 1 83  GLN 83  83  83  GLN GLN A . n 
A 1 84  ASN 84  84  84  ASN ASN A . n 
A 1 85  CYS 85  85  85  CYS CYS A . n 
A 1 86  VAL 86  86  86  VAL VAL A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  LYS 88  88  88  LYS LYS A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  LYS 90  90  90  LYS LYS A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  ASP 92  92  92  ASP ASP A . n 
A 1 93  THR 93  93  93  THR THR A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  PRO 96  96  96  PRO PRO A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  PRO 99  99  99  PRO PRO A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 TYR 101 101 101 TYR TYR A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 PHE 103 103 103 PHE PHE A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 ARG 105 105 105 ARG ARG A . n 
A 1 106 ILE 106 106 106 ILE ILE A . n 
A 1 107 GLN 107 107 107 GLN GLN A . n 
A 1 108 PRO 108 108 108 PRO PRO A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 GLN 110 110 110 GLN GLN A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 PHE 112 112 112 PHE PHE A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 CYS 117 117 117 CYS CYS A . n 
A 1 118 TYR 118 118 118 TYR TYR A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 SER 123 123 123 SER SER A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 MET 130 130 130 MET MET A . n 
A 1 131 ARG 131 131 131 ARG ARG A . n 
A 1 132 PRO 132 132 132 PRO PRO A . n 
A 1 133 ASN 133 133 133 ASN ASN A . n 
A 1 134 PHE 134 134 134 PHE PHE A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 LYS 137 137 137 LYS LYS A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 PHE 140 140 140 PHE PHE A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 ASN 142 142 142 ASN ASN A . n 
A 1 143 GLY 143 143 143 GLY GLY A . n 
A 1 144 SER 144 144 144 SER SER A . n 
A 1 145 CYS 145 145 145 CYS CYS A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 GLY 149 149 149 GLY GLY A . n 
A 1 150 PHE 150 150 150 PHE PHE A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 ILE 152 152 152 ILE ILE A . n 
A 1 153 ASP 153 153 153 ASP ASP A . n 
A 1 154 TYR 154 154 154 TYR TYR A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 CYS 156 156 156 CYS CYS A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 SER 158 158 158 SER SER A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 CYS 160 160 160 CYS CYS A . n 
A 1 161 TYR 161 161 161 TYR TYR A . n 
A 1 162 MET 162 162 162 MET MET A . n 
A 1 163 HIS 163 163 163 HIS HIS A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 MET 165 165 165 MET MET A . n 
A 1 166 GLU 166 166 166 GLU GLU A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 PRO 168 168 168 PRO PRO A . n 
A 1 169 THR 169 169 169 THR THR A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 VAL 171 171 171 VAL VAL A . n 
A 1 172 HIS 172 172 172 HIS HIS A . n 
A 1 173 ALA 173 173 173 ALA ALA A . n 
A 1 174 GLY 174 174 174 GLY GLY A . n 
A 1 175 THR 175 175 175 THR THR A . n 
A 1 176 ASP 176 176 176 ASP ASP A . n 
A 1 177 LEU 177 177 177 LEU LEU A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 TYR 182 182 182 TYR TYR A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 VAL 186 186 186 VAL VAL A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 GLN 189 189 189 GLN GLN A . n 
A 1 190 ILE 190 190 190 ILE ILE A . n 
A 1 191 ALA 191 191 191 ALA ALA A . n 
A 1 192 GLN 192 192 192 GLN GLN A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 THR 196 196 196 THR THR A . n 
A 1 197 ASP 197 197 197 ASP ASP A . n 
A 1 198 THR 198 198 198 THR THR A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 ILE 200 200 200 ILE ILE A . n 
A 1 201 THR 201 201 201 THR THR A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 ALA 206 206 206 ALA ALA A . n 
A 1 207 TRP 207 207 207 TRP TRP A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ALA 210 210 210 ALA ALA A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ASN 214 214 214 ASN ASN A . n 
A 1 215 GLY 215 215 215 GLY GLY A . n 
A 1 216 ASP 216 216 216 ASP ASP A . n 
A 1 217 ARG 217 217 217 ARG ARG A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 ASN 221 221 221 ASN ASN A . n 
A 1 222 ARG 222 222 222 ARG ARG A . n 
A 1 223 PHE 223 223 223 PHE PHE A . n 
A 1 224 THR 224 224 224 THR THR A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 THR 226 226 226 THR THR A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 ASN 228 228 228 ASN ASN A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 PHE 230 230 230 PHE PHE A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 VAL 233 233 233 VAL VAL A . n 
A 1 234 ALA 234 234 234 ALA ALA A . n 
A 1 235 MET 235 235 235 MET MET A . n 
A 1 236 LYS 236 236 236 LYS LYS A . n 
A 1 237 TYR 237 237 237 TYR TYR A . n 
A 1 238 ASN 238 238 238 ASN ASN A . n 
A 1 239 TYR 239 239 239 TYR TYR A . n 
A 1 240 GLU 240 240 240 GLU GLU A . n 
A 1 241 PRO 241 241 241 PRO PRO A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 THR 243 243 243 THR THR A . n 
A 1 244 GLN 244 244 244 GLN GLN A . n 
A 1 245 ASP 245 245 245 ASP ASP A . n 
A 1 246 HIS 246 246 246 HIS HIS A . n 
A 1 247 VAL 247 247 247 VAL VAL A . n 
A 1 248 ASP 248 248 248 ASP ASP A . n 
A 1 249 ILE 249 249 249 ILE ILE A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 PRO 252 252 252 PRO PRO A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 SER 254 254 254 SER SER A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 THR 257 257 257 THR THR A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 ILE 259 259 259 ILE ILE A . n 
A 1 260 ALA 260 260 260 ALA ALA A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 LEU 262 262 262 LEU LEU A . n 
A 1 263 ASP 263 263 263 ASP ASP A . n 
A 1 264 MET 264 264 264 MET MET A . n 
A 1 265 CYS 265 265 265 CYS CYS A . n 
A 1 266 ALA 266 266 266 ALA ALA A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 LYS 269 269 269 LYS LYS A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 LEU 271 271 271 LEU LEU A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 ASN 274 274 274 ASN ASN A . n 
A 1 275 GLY 275 275 275 GLY GLY A . n 
A 1 276 MET 276 276 276 MET MET A . n 
A 1 277 ASN 277 277 277 ASN ASN A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 ARG 279 279 279 ARG ARG A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 ILE 281 281 281 ILE ILE A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 GLY 283 283 283 GLY GLY A . n 
A 1 284 SER 284 284 284 SER SER A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 LEU 286 286 286 LEU LEU A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 ASP 289 289 289 ASP ASP A . n 
A 1 290 GLU 290 290 290 GLU GLU A . n 
A 1 291 PHE 291 291 291 PHE PHE A . n 
A 1 292 THR 292 292 292 THR THR A . n 
A 1 293 PRO 293 293 293 PRO PRO A . n 
A 1 294 PHE 294 294 294 PHE PHE A . n 
A 1 295 ASP 295 295 295 ASP ASP A . n 
A 1 296 VAL 296 296 296 VAL VAL A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 GLN 299 299 299 GLN GLN A . n 
A 1 300 CYS 300 300 300 CYS CYS A . n 
A 1 301 SER 301 301 301 SER SER A . n 
A 1 302 GLY 302 302 ?   ?   ?   A . n 
A 1 303 VAL 303 303 ?   ?   ?   A . n 
A 1 304 THR 304 304 ?   ?   ?   A . n 
A 1 305 PHE 305 305 ?   ?   ?   A . n 
A 1 306 GLN 306 306 ?   ?   ?   A . n 
B 1 1   SER 1   1   1   SER SER B . n 
B 1 2   GLY 2   2   2   GLY GLY B . n 
B 1 3   PHE 3   3   3   PHE PHE B . n 
B 1 4   ARG 4   4   4   ARG ARG B . n 
B 1 5   LYS 5   5   5   LYS LYS B . n 
B 1 6   MET 6   6   6   MET MET B . n 
B 1 7   ALA 7   7   7   ALA ALA B . n 
B 1 8   PHE 8   8   8   PHE PHE B . n 
B 1 9   PRO 9   9   9   PRO PRO B . n 
B 1 10  SER 10  10  10  SER SER B . n 
B 1 11  GLY 11  11  11  GLY GLY B . n 
B 1 12  LYS 12  12  12  LYS LYS B . n 
B 1 13  VAL 13  13  13  VAL VAL B . n 
B 1 14  GLU 14  14  14  GLU GLU B . n 
B 1 15  GLY 15  15  15  GLY GLY B . n 
B 1 16  CYS 16  16  16  CYS CYS B . n 
B 1 17  MET 17  17  17  MET MET B . n 
B 1 18  VAL 18  18  18  VAL VAL B . n 
B 1 19  GLN 19  19  19  GLN GLN B . n 
B 1 20  VAL 20  20  20  VAL VAL B . n 
B 1 21  THR 21  21  21  THR THR B . n 
B 1 22  CYS 22  22  22  CYS CYS B . n 
B 1 23  GLY 23  23  23  GLY GLY B . n 
B 1 24  THR 24  24  24  THR THR B . n 
B 1 25  THR 25  25  25  THR THR B . n 
B 1 26  THR 26  26  26  THR THR B . n 
B 1 27  LEU 27  27  27  LEU LEU B . n 
B 1 28  ASN 28  28  28  ASN ASN B . n 
B 1 29  GLY 29  29  29  GLY GLY B . n 
B 1 30  LEU 30  30  30  LEU LEU B . n 
B 1 31  TRP 31  31  31  TRP TRP B . n 
B 1 32  LEU 32  32  32  LEU LEU B . n 
B 1 33  ASP 33  33  33  ASP ASP B . n 
B 1 34  ASP 34  34  34  ASP ASP B . n 
B 1 35  VAL 35  35  35  VAL VAL B . n 
B 1 36  VAL 36  36  36  VAL VAL B . n 
B 1 37  TYR 37  37  37  TYR TYR B . n 
B 1 38  CYS 38  38  38  CYS CYS B . n 
B 1 39  PRO 39  39  39  PRO PRO B . n 
B 1 40  ARG 40  40  40  ARG ARG B . n 
B 1 41  HIS 41  41  41  HIS HIS B . n 
B 1 42  VAL 42  42  42  VAL VAL B . n 
B 1 43  ILE 43  43  43  ILE ILE B . n 
B 1 44  CYS 44  44  44  CYS CYS B . n 
B 1 45  THR 45  45  45  THR THR B . n 
B 1 46  SER 46  46  46  SER SER B . n 
B 1 47  GLU 47  47  47  GLU GLU B . n 
B 1 48  ASP 48  48  48  ASP ASP B . n 
B 1 49  MET 49  49  49  MET MET B . n 
B 1 50  LEU 50  50  50  LEU LEU B . n 
B 1 51  ASN 51  51  51  ASN ASN B . n 
B 1 52  PRO 52  52  52  PRO PRO B . n 
B 1 53  ASN 53  53  53  ASN ASN B . n 
B 1 54  TYR 54  54  54  TYR TYR B . n 
B 1 55  GLU 55  55  55  GLU GLU B . n 
B 1 56  ASP 56  56  56  ASP ASP B . n 
B 1 57  LEU 57  57  57  LEU LEU B . n 
B 1 58  LEU 58  58  58  LEU LEU B . n 
B 1 59  ILE 59  59  59  ILE ILE B . n 
B 1 60  ARG 60  60  60  ARG ARG B . n 
B 1 61  LYS 61  61  61  LYS LYS B . n 
B 1 62  SER 62  62  62  SER SER B . n 
B 1 63  ASN 63  63  63  ASN ASN B . n 
B 1 64  HIS 64  64  64  HIS HIS B . n 
B 1 65  ASN 65  65  65  ASN ASN B . n 
B 1 66  PHE 66  66  66  PHE PHE B . n 
B 1 67  LEU 67  67  67  LEU LEU B . n 
B 1 68  VAL 68  68  68  VAL VAL B . n 
B 1 69  GLN 69  69  69  GLN GLN B . n 
B 1 70  ALA 70  70  70  ALA ALA B . n 
B 1 71  GLY 71  71  71  GLY GLY B . n 
B 1 72  ASN 72  72  72  ASN ASN B . n 
B 1 73  VAL 73  73  73  VAL VAL B . n 
B 1 74  GLN 74  74  74  GLN GLN B . n 
B 1 75  LEU 75  75  75  LEU LEU B . n 
B 1 76  ARG 76  76  76  ARG ARG B . n 
B 1 77  VAL 77  77  77  VAL VAL B . n 
B 1 78  ILE 78  78  78  ILE ILE B . n 
B 1 79  GLY 79  79  79  GLY GLY B . n 
B 1 80  HIS 80  80  80  HIS HIS B . n 
B 1 81  SER 81  81  81  SER SER B . n 
B 1 82  MET 82  82  82  MET MET B . n 
B 1 83  GLN 83  83  83  GLN GLN B . n 
B 1 84  ASN 84  84  84  ASN ASN B . n 
B 1 85  CYS 85  85  85  CYS CYS B . n 
B 1 86  VAL 86  86  86  VAL VAL B . n 
B 1 87  LEU 87  87  87  LEU LEU B . n 
B 1 88  LYS 88  88  88  LYS LYS B . n 
B 1 89  LEU 89  89  89  LEU LEU B . n 
B 1 90  LYS 90  90  90  LYS LYS B . n 
B 1 91  VAL 91  91  91  VAL VAL B . n 
B 1 92  ASP 92  92  92  ASP ASP B . n 
B 1 93  THR 93  93  93  THR THR B . n 
B 1 94  ALA 94  94  94  ALA ALA B . n 
B 1 95  ASN 95  95  95  ASN ASN B . n 
B 1 96  PRO 96  96  96  PRO PRO B . n 
B 1 97  LYS 97  97  97  LYS LYS B . n 
B 1 98  THR 98  98  98  THR THR B . n 
B 1 99  PRO 99  99  99  PRO PRO B . n 
B 1 100 LYS 100 100 100 LYS LYS B . n 
B 1 101 TYR 101 101 101 TYR TYR B . n 
B 1 102 LYS 102 102 102 LYS LYS B . n 
B 1 103 PHE 103 103 103 PHE PHE B . n 
B 1 104 VAL 104 104 104 VAL VAL B . n 
B 1 105 ARG 105 105 105 ARG ARG B . n 
B 1 106 ILE 106 106 106 ILE ILE B . n 
B 1 107 GLN 107 107 107 GLN GLN B . n 
B 1 108 PRO 108 108 108 PRO PRO B . n 
B 1 109 GLY 109 109 109 GLY GLY B . n 
B 1 110 GLN 110 110 110 GLN GLN B . n 
B 1 111 THR 111 111 111 THR THR B . n 
B 1 112 PHE 112 112 112 PHE PHE B . n 
B 1 113 SER 113 113 113 SER SER B . n 
B 1 114 VAL 114 114 114 VAL VAL B . n 
B 1 115 LEU 115 115 115 LEU LEU B . n 
B 1 116 ALA 116 116 116 ALA ALA B . n 
B 1 117 CYS 117 117 117 CYS CYS B . n 
B 1 118 TYR 118 118 118 TYR TYR B . n 
B 1 119 ASN 119 119 119 ASN ASN B . n 
B 1 120 GLY 120 120 120 GLY GLY B . n 
B 1 121 SER 121 121 121 SER SER B . n 
B 1 122 PRO 122 122 122 PRO PRO B . n 
B 1 123 SER 123 123 123 SER SER B . n 
B 1 124 GLY 124 124 124 GLY GLY B . n 
B 1 125 VAL 125 125 125 VAL VAL B . n 
B 1 126 TYR 126 126 126 TYR TYR B . n 
B 1 127 GLN 127 127 127 GLN GLN B . n 
B 1 128 CYS 128 128 128 CYS CYS B . n 
B 1 129 ALA 129 129 129 ALA ALA B . n 
B 1 130 MET 130 130 130 MET MET B . n 
B 1 131 ARG 131 131 131 ARG ARG B . n 
B 1 132 PRO 132 132 132 PRO PRO B . n 
B 1 133 ASN 133 133 133 ASN ASN B . n 
B 1 134 PHE 134 134 134 PHE PHE B . n 
B 1 135 THR 135 135 135 THR THR B . n 
B 1 136 ILE 136 136 136 ILE ILE B . n 
B 1 137 LYS 137 137 137 LYS LYS B . n 
B 1 138 GLY 138 138 138 GLY GLY B . n 
B 1 139 SER 139 139 139 SER SER B . n 
B 1 140 PHE 140 140 140 PHE PHE B . n 
B 1 141 LEU 141 141 141 LEU LEU B . n 
B 1 142 ASN 142 142 142 ASN ASN B . n 
B 1 143 GLY 143 143 143 GLY GLY B . n 
B 1 144 SER 144 144 144 SER SER B . n 
B 1 145 CYS 145 145 145 CYS CYS B . n 
B 1 146 GLY 146 146 146 GLY GLY B . n 
B 1 147 SER 147 147 147 SER SER B . n 
B 1 148 VAL 148 148 148 VAL VAL B . n 
B 1 149 GLY 149 149 149 GLY GLY B . n 
B 1 150 PHE 150 150 150 PHE PHE B . n 
B 1 151 ASN 151 151 151 ASN ASN B . n 
B 1 152 ILE 152 152 152 ILE ILE B . n 
B 1 153 ASP 153 153 153 ASP ASP B . n 
B 1 154 TYR 154 154 154 TYR TYR B . n 
B 1 155 ASP 155 155 155 ASP ASP B . n 
B 1 156 CYS 156 156 156 CYS CYS B . n 
B 1 157 VAL 157 157 157 VAL VAL B . n 
B 1 158 SER 158 158 158 SER SER B . n 
B 1 159 PHE 159 159 159 PHE PHE B . n 
B 1 160 CYS 160 160 160 CYS CYS B . n 
B 1 161 TYR 161 161 161 TYR TYR B . n 
B 1 162 MET 162 162 162 MET MET B . n 
B 1 163 HIS 163 163 163 HIS HIS B . n 
B 1 164 HIS 164 164 164 HIS HIS B . n 
B 1 165 MET 165 165 165 MET MET B . n 
B 1 166 GLU 166 166 166 GLU GLU B . n 
B 1 167 LEU 167 167 167 LEU LEU B . n 
B 1 168 PRO 168 168 168 PRO PRO B . n 
B 1 169 THR 169 169 169 THR THR B . n 
B 1 170 GLY 170 170 170 GLY GLY B . n 
B 1 171 VAL 171 171 171 VAL VAL B . n 
B 1 172 HIS 172 172 172 HIS HIS B . n 
B 1 173 ALA 173 173 173 ALA ALA B . n 
B 1 174 GLY 174 174 174 GLY GLY B . n 
B 1 175 THR 175 175 175 THR THR B . n 
B 1 176 ASP 176 176 176 ASP ASP B . n 
B 1 177 LEU 177 177 177 LEU LEU B . n 
B 1 178 GLU 178 178 178 GLU GLU B . n 
B 1 179 GLY 179 179 179 GLY GLY B . n 
B 1 180 ASN 180 180 180 ASN ASN B . n 
B 1 181 PHE 181 181 181 PHE PHE B . n 
B 1 182 TYR 182 182 182 TYR TYR B . n 
B 1 183 GLY 183 183 183 GLY GLY B . n 
B 1 184 PRO 184 184 184 PRO PRO B . n 
B 1 185 PHE 185 185 185 PHE PHE B . n 
B 1 186 VAL 186 186 186 VAL VAL B . n 
B 1 187 ASP 187 187 187 ASP ASP B . n 
B 1 188 ARG 188 188 188 ARG ARG B . n 
B 1 189 GLN 189 189 189 GLN GLN B . n 
B 1 190 ILE 190 190 190 ILE ILE B . n 
B 1 191 ALA 191 191 191 ALA ALA B . n 
B 1 192 GLN 192 192 192 GLN GLN B . n 
B 1 193 ALA 193 193 193 ALA ALA B . n 
B 1 194 ALA 194 194 194 ALA ALA B . n 
B 1 195 GLY 195 195 195 GLY GLY B . n 
B 1 196 THR 196 196 196 THR THR B . n 
B 1 197 ASP 197 197 197 ASP ASP B . n 
B 1 198 THR 198 198 198 THR THR B . n 
B 1 199 THR 199 199 199 THR THR B . n 
B 1 200 ILE 200 200 200 ILE ILE B . n 
B 1 201 THR 201 201 201 THR THR B . n 
B 1 202 VAL 202 202 202 VAL VAL B . n 
B 1 203 ASN 203 203 203 ASN ASN B . n 
B 1 204 VAL 204 204 204 VAL VAL B . n 
B 1 205 LEU 205 205 205 LEU LEU B . n 
B 1 206 ALA 206 206 206 ALA ALA B . n 
B 1 207 TRP 207 207 207 TRP TRP B . n 
B 1 208 LEU 208 208 208 LEU LEU B . n 
B 1 209 TYR 209 209 209 TYR TYR B . n 
B 1 210 ALA 210 210 210 ALA ALA B . n 
B 1 211 ALA 211 211 211 ALA ALA B . n 
B 1 212 VAL 212 212 212 VAL VAL B . n 
B 1 213 ILE 213 213 213 ILE ILE B . n 
B 1 214 ASN 214 214 214 ASN ASN B . n 
B 1 215 GLY 215 215 215 GLY GLY B . n 
B 1 216 ASP 216 216 216 ASP ASP B . n 
B 1 217 ARG 217 217 217 ARG ARG B . n 
B 1 218 TRP 218 218 218 TRP TRP B . n 
B 1 219 PHE 219 219 219 PHE PHE B . n 
B 1 220 LEU 220 220 220 LEU LEU B . n 
B 1 221 ASN 221 221 221 ASN ASN B . n 
B 1 222 ARG 222 222 222 ARG ARG B . n 
B 1 223 PHE 223 223 223 PHE PHE B . n 
B 1 224 THR 224 224 224 THR THR B . n 
B 1 225 THR 225 225 225 THR THR B . n 
B 1 226 THR 226 226 226 THR THR B . n 
B 1 227 LEU 227 227 227 LEU LEU B . n 
B 1 228 ASN 228 228 228 ASN ASN B . n 
B 1 229 ASP 229 229 229 ASP ASP B . n 
B 1 230 PHE 230 230 230 PHE PHE B . n 
B 1 231 ASN 231 231 231 ASN ASN B . n 
B 1 232 LEU 232 232 232 LEU LEU B . n 
B 1 233 VAL 233 233 233 VAL VAL B . n 
B 1 234 ALA 234 234 234 ALA ALA B . n 
B 1 235 MET 235 235 235 MET MET B . n 
B 1 236 LYS 236 236 236 LYS LYS B . n 
B 1 237 TYR 237 237 237 TYR TYR B . n 
B 1 238 ASN 238 238 238 ASN ASN B . n 
B 1 239 TYR 239 239 239 TYR TYR B . n 
B 1 240 GLU 240 240 240 GLU GLU B . n 
B 1 241 PRO 241 241 241 PRO PRO B . n 
B 1 242 LEU 242 242 242 LEU LEU B . n 
B 1 243 THR 243 243 243 THR THR B . n 
B 1 244 GLN 244 244 244 GLN GLN B . n 
B 1 245 ASP 245 245 245 ASP ASP B . n 
B 1 246 HIS 246 246 246 HIS HIS B . n 
B 1 247 VAL 247 247 247 VAL VAL B . n 
B 1 248 ASP 248 248 248 ASP ASP B . n 
B 1 249 ILE 249 249 249 ILE ILE B . n 
B 1 250 LEU 250 250 250 LEU LEU B . n 
B 1 251 GLY 251 251 251 GLY GLY B . n 
B 1 252 PRO 252 252 252 PRO PRO B . n 
B 1 253 LEU 253 253 253 LEU LEU B . n 
B 1 254 SER 254 254 254 SER SER B . n 
B 1 255 ALA 255 255 255 ALA ALA B . n 
B 1 256 GLN 256 256 256 GLN GLN B . n 
B 1 257 THR 257 257 257 THR THR B . n 
B 1 258 GLY 258 258 258 GLY GLY B . n 
B 1 259 ILE 259 259 259 ILE ILE B . n 
B 1 260 ALA 260 260 260 ALA ALA B . n 
B 1 261 VAL 261 261 261 VAL VAL B . n 
B 1 262 LEU 262 262 262 LEU LEU B . n 
B 1 263 ASP 263 263 263 ASP ASP B . n 
B 1 264 MET 264 264 264 MET MET B . n 
B 1 265 CYS 265 265 265 CYS CYS B . n 
B 1 266 ALA 266 266 266 ALA ALA B . n 
B 1 267 SER 267 267 267 SER SER B . n 
B 1 268 LEU 268 268 268 LEU LEU B . n 
B 1 269 LYS 269 269 269 LYS LYS B . n 
B 1 270 GLU 270 270 270 GLU GLU B . n 
B 1 271 LEU 271 271 271 LEU LEU B . n 
B 1 272 LEU 272 272 272 LEU LEU B . n 
B 1 273 GLN 273 273 273 GLN GLN B . n 
B 1 274 ASN 274 274 274 ASN ASN B . n 
B 1 275 GLY 275 275 275 GLY GLY B . n 
B 1 276 MET 276 276 276 MET MET B . n 
B 1 277 ASN 277 277 277 ASN ASN B . n 
B 1 278 GLY 278 278 278 GLY GLY B . n 
B 1 279 ARG 279 279 279 ARG ARG B . n 
B 1 280 THR 280 280 280 THR THR B . n 
B 1 281 ILE 281 281 281 ILE ILE B . n 
B 1 282 LEU 282 282 282 LEU LEU B . n 
B 1 283 GLY 283 283 283 GLY GLY B . n 
B 1 284 SER 284 284 284 SER SER B . n 
B 1 285 ALA 285 285 285 ALA ALA B . n 
B 1 286 LEU 286 286 286 LEU LEU B . n 
B 1 287 LEU 287 287 287 LEU LEU B . n 
B 1 288 GLU 288 288 288 GLU GLU B . n 
B 1 289 ASP 289 289 289 ASP ASP B . n 
B 1 290 GLU 290 290 290 GLU GLU B . n 
B 1 291 PHE 291 291 291 PHE PHE B . n 
B 1 292 THR 292 292 292 THR THR B . n 
B 1 293 PRO 293 293 293 PRO PRO B . n 
B 1 294 PHE 294 294 294 PHE PHE B . n 
B 1 295 ASP 295 295 295 ASP ASP B . n 
B 1 296 VAL 296 296 296 VAL VAL B . n 
B 1 297 VAL 297 297 297 VAL VAL B . n 
B 1 298 ARG 298 298 298 ARG ARG B . n 
B 1 299 GLN 299 299 299 GLN GLN B . n 
B 1 300 CYS 300 300 300 CYS CYS B . n 
B 1 301 SER 301 301 301 SER SER B . n 
B 1 302 GLY 302 302 302 GLY GLY B . n 
B 1 303 VAL 303 303 303 VAL VAL B . n 
B 1 304 THR 304 304 304 THR THR B . n 
B 1 305 PHE 305 305 305 PHE PHE B . n 
B 1 306 GLN 306 306 ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        XEK 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   XEK 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 XEK 1   401 1   XEK M61 A . 
D 3 HOH 1   501 182 HOH HOH A . 
D 3 HOH 2   502 357 HOH HOH A . 
D 3 HOH 3   503 177 HOH HOH A . 
D 3 HOH 4   504 179 HOH HOH A . 
D 3 HOH 5   505 109 HOH HOH A . 
D 3 HOH 6   506 168 HOH HOH A . 
D 3 HOH 7   507 69  HOH HOH A . 
D 3 HOH 8   508 335 HOH HOH A . 
D 3 HOH 9   509 201 HOH HOH A . 
D 3 HOH 10  510 344 HOH HOH A . 
D 3 HOH 11  511 141 HOH HOH A . 
D 3 HOH 12  512 191 HOH HOH A . 
D 3 HOH 13  513 247 HOH HOH A . 
D 3 HOH 14  514 209 HOH HOH A . 
D 3 HOH 15  515 19  HOH HOH A . 
D 3 HOH 16  516 246 HOH HOH A . 
D 3 HOH 17  517 225 HOH HOH A . 
D 3 HOH 18  518 289 HOH HOH A . 
D 3 HOH 19  519 192 HOH HOH A . 
D 3 HOH 20  520 103 HOH HOH A . 
D 3 HOH 21  521 132 HOH HOH A . 
D 3 HOH 22  522 189 HOH HOH A . 
D 3 HOH 23  523 35  HOH HOH A . 
D 3 HOH 24  524 134 HOH HOH A . 
D 3 HOH 25  525 142 HOH HOH A . 
D 3 HOH 26  526 286 HOH HOH A . 
D 3 HOH 27  527 128 HOH HOH A . 
D 3 HOH 28  528 382 HOH HOH A . 
D 3 HOH 29  529 116 HOH HOH A . 
D 3 HOH 30  530 29  HOH HOH A . 
D 3 HOH 31  531 96  HOH HOH A . 
D 3 HOH 32  532 146 HOH HOH A . 
D 3 HOH 33  533 94  HOH HOH A . 
D 3 HOH 34  534 40  HOH HOH A . 
D 3 HOH 35  535 232 HOH HOH A . 
D 3 HOH 36  536 84  HOH HOH A . 
D 3 HOH 37  537 58  HOH HOH A . 
D 3 HOH 38  538 88  HOH HOH A . 
D 3 HOH 39  539 47  HOH HOH A . 
D 3 HOH 40  540 348 HOH HOH A . 
D 3 HOH 41  541 21  HOH HOH A . 
D 3 HOH 42  542 240 HOH HOH A . 
D 3 HOH 43  543 360 HOH HOH A . 
D 3 HOH 44  544 56  HOH HOH A . 
D 3 HOH 45  545 304 HOH HOH A . 
D 3 HOH 46  546 299 HOH HOH A . 
D 3 HOH 47  547 231 HOH HOH A . 
D 3 HOH 48  548 37  HOH HOH A . 
D 3 HOH 49  549 27  HOH HOH A . 
D 3 HOH 50  550 71  HOH HOH A . 
D 3 HOH 51  551 85  HOH HOH A . 
D 3 HOH 52  552 208 HOH HOH A . 
D 3 HOH 53  553 156 HOH HOH A . 
D 3 HOH 54  554 46  HOH HOH A . 
D 3 HOH 55  555 275 HOH HOH A . 
D 3 HOH 56  556 145 HOH HOH A . 
D 3 HOH 57  557 24  HOH HOH A . 
D 3 HOH 58  558 149 HOH HOH A . 
D 3 HOH 59  559 14  HOH HOH A . 
D 3 HOH 60  560 218 HOH HOH A . 
D 3 HOH 61  561 45  HOH HOH A . 
D 3 HOH 62  562 4   HOH HOH A . 
D 3 HOH 63  563 8   HOH HOH A . 
D 3 HOH 64  564 16  HOH HOH A . 
D 3 HOH 65  565 51  HOH HOH A . 
D 3 HOH 66  566 3   HOH HOH A . 
D 3 HOH 67  567 38  HOH HOH A . 
D 3 HOH 68  568 152 HOH HOH A . 
D 3 HOH 69  569 111 HOH HOH A . 
D 3 HOH 70  570 125 HOH HOH A . 
D 3 HOH 71  571 75  HOH HOH A . 
D 3 HOH 72  572 239 HOH HOH A . 
D 3 HOH 73  573 320 HOH HOH A . 
D 3 HOH 74  574 266 HOH HOH A . 
D 3 HOH 75  575 102 HOH HOH A . 
D 3 HOH 76  576 150 HOH HOH A . 
D 3 HOH 77  577 249 HOH HOH A . 
D 3 HOH 78  578 155 HOH HOH A . 
D 3 HOH 79  579 328 HOH HOH A . 
D 3 HOH 80  580 110 HOH HOH A . 
D 3 HOH 81  581 215 HOH HOH A . 
D 3 HOH 82  582 171 HOH HOH A . 
D 3 HOH 83  583 36  HOH HOH A . 
D 3 HOH 84  584 50  HOH HOH A . 
D 3 HOH 85  585 115 HOH HOH A . 
D 3 HOH 86  586 292 HOH HOH A . 
D 3 HOH 87  587 112 HOH HOH A . 
D 3 HOH 88  588 5   HOH HOH A . 
D 3 HOH 89  589 11  HOH HOH A . 
D 3 HOH 90  590 44  HOH HOH A . 
D 3 HOH 91  591 137 HOH HOH A . 
D 3 HOH 92  592 95  HOH HOH A . 
D 3 HOH 93  593 65  HOH HOH A . 
D 3 HOH 94  594 25  HOH HOH A . 
D 3 HOH 95  595 148 HOH HOH A . 
D 3 HOH 96  596 100 HOH HOH A . 
D 3 HOH 97  597 381 HOH HOH A . 
D 3 HOH 98  598 188 HOH HOH A . 
D 3 HOH 99  599 130 HOH HOH A . 
D 3 HOH 100 600 68  HOH HOH A . 
D 3 HOH 101 601 120 HOH HOH A . 
D 3 HOH 102 602 227 HOH HOH A . 
D 3 HOH 103 603 43  HOH HOH A . 
D 3 HOH 104 604 133 HOH HOH A . 
D 3 HOH 105 605 122 HOH HOH A . 
D 3 HOH 106 606 202 HOH HOH A . 
D 3 HOH 107 607 32  HOH HOH A . 
D 3 HOH 108 608 296 HOH HOH A . 
D 3 HOH 109 609 89  HOH HOH A . 
D 3 HOH 110 610 55  HOH HOH A . 
D 3 HOH 111 611 23  HOH HOH A . 
D 3 HOH 112 612 49  HOH HOH A . 
D 3 HOH 113 613 113 HOH HOH A . 
D 3 HOH 114 614 15  HOH HOH A . 
D 3 HOH 115 615 198 HOH HOH A . 
D 3 HOH 116 616 203 HOH HOH A . 
D 3 HOH 117 617 254 HOH HOH A . 
D 3 HOH 118 618 53  HOH HOH A . 
D 3 HOH 119 619 67  HOH HOH A . 
D 3 HOH 120 620 33  HOH HOH A . 
D 3 HOH 121 621 119 HOH HOH A . 
D 3 HOH 122 622 121 HOH HOH A . 
D 3 HOH 123 623 118 HOH HOH A . 
D 3 HOH 124 624 6   HOH HOH A . 
D 3 HOH 125 625 197 HOH HOH A . 
D 3 HOH 126 626 377 HOH HOH A . 
D 3 HOH 127 627 98  HOH HOH A . 
D 3 HOH 128 628 176 HOH HOH A . 
D 3 HOH 129 629 319 HOH HOH A . 
D 3 HOH 130 630 126 HOH HOH A . 
D 3 HOH 131 631 352 HOH HOH A . 
D 3 HOH 132 632 79  HOH HOH A . 
D 3 HOH 133 633 66  HOH HOH A . 
D 3 HOH 134 634 129 HOH HOH A . 
D 3 HOH 135 635 10  HOH HOH A . 
D 3 HOH 136 636 13  HOH HOH A . 
D 3 HOH 137 637 347 HOH HOH A . 
D 3 HOH 138 638 77  HOH HOH A . 
D 3 HOH 139 639 91  HOH HOH A . 
D 3 HOH 140 640 244 HOH HOH A . 
D 3 HOH 141 641 300 HOH HOH A . 
D 3 HOH 142 642 241 HOH HOH A . 
D 3 HOH 143 643 379 HOH HOH A . 
D 3 HOH 144 644 284 HOH HOH A . 
D 3 HOH 145 645 193 HOH HOH A . 
D 3 HOH 146 646 301 HOH HOH A . 
D 3 HOH 147 647 262 HOH HOH A . 
D 3 HOH 148 648 175 HOH HOH A . 
D 3 HOH 149 649 235 HOH HOH A . 
D 3 HOH 150 650 294 HOH HOH A . 
D 3 HOH 151 651 291 HOH HOH A . 
D 3 HOH 152 652 78  HOH HOH A . 
D 3 HOH 153 653 374 HOH HOH A . 
D 3 HOH 154 654 322 HOH HOH A . 
D 3 HOH 155 655 261 HOH HOH A . 
D 3 HOH 156 656 181 HOH HOH A . 
D 3 HOH 157 657 346 HOH HOH A . 
D 3 HOH 158 658 161 HOH HOH A . 
D 3 HOH 159 659 334 HOH HOH A . 
D 3 HOH 160 660 281 HOH HOH A . 
D 3 HOH 161 661 355 HOH HOH A . 
D 3 HOH 162 662 237 HOH HOH A . 
D 3 HOH 163 663 131 HOH HOH A . 
D 3 HOH 164 664 305 HOH HOH A . 
D 3 HOH 165 665 263 HOH HOH A . 
D 3 HOH 166 666 194 HOH HOH A . 
D 3 HOH 167 667 233 HOH HOH A . 
D 3 HOH 168 668 236 HOH HOH A . 
D 3 HOH 169 669 339 HOH HOH A . 
D 3 HOH 170 670 331 HOH HOH A . 
D 3 HOH 171 671 361 HOH HOH A . 
D 3 HOH 172 672 309 HOH HOH A . 
D 3 HOH 173 673 257 HOH HOH A . 
D 3 HOH 174 674 317 HOH HOH A . 
D 3 HOH 175 675 205 HOH HOH A . 
D 3 HOH 176 676 364 HOH HOH A . 
D 3 HOH 177 677 337 HOH HOH A . 
D 3 HOH 178 678 259 HOH HOH A . 
D 3 HOH 179 679 273 HOH HOH A . 
D 3 HOH 180 680 375 HOH HOH A . 
D 3 HOH 181 681 298 HOH HOH A . 
D 3 HOH 182 682 245 HOH HOH A . 
D 3 HOH 183 683 229 HOH HOH A . 
D 3 HOH 184 684 282 HOH HOH A . 
D 3 HOH 185 685 243 HOH HOH A . 
D 3 HOH 186 686 211 HOH HOH A . 
D 3 HOH 187 687 310 HOH HOH A . 
D 3 HOH 188 688 276 HOH HOH A . 
D 3 HOH 189 689 272 HOH HOH A . 
D 3 HOH 190 690 238 HOH HOH A . 
D 3 HOH 191 691 207 HOH HOH A . 
D 3 HOH 192 692 217 HOH HOH A . 
D 3 HOH 193 693 256 HOH HOH A . 
D 3 HOH 194 694 158 HOH HOH A . 
D 3 HOH 195 695 206 HOH HOH A . 
D 3 HOH 196 696 324 HOH HOH A . 
D 3 HOH 197 697 140 HOH HOH A . 
D 3 HOH 198 698 267 HOH HOH A . 
D 3 HOH 199 699 264 HOH HOH A . 
D 3 HOH 200 700 138 HOH HOH A . 
D 3 HOH 201 701 277 HOH HOH A . 
D 3 HOH 202 702 384 HOH HOH A . 
D 3 HOH 203 703 354 HOH HOH A . 
E 3 HOH 1   401 295 HOH HOH B . 
E 3 HOH 2   402 139 HOH HOH B . 
E 3 HOH 3   403 253 HOH HOH B . 
E 3 HOH 4   404 224 HOH HOH B . 
E 3 HOH 5   405 332 HOH HOH B . 
E 3 HOH 6   406 213 HOH HOH B . 
E 3 HOH 7   407 151 HOH HOH B . 
E 3 HOH 8   408 195 HOH HOH B . 
E 3 HOH 9   409 41  HOH HOH B . 
E 3 HOH 10  410 336 HOH HOH B . 
E 3 HOH 11  411 303 HOH HOH B . 
E 3 HOH 12  412 173 HOH HOH B . 
E 3 HOH 13  413 97  HOH HOH B . 
E 3 HOH 14  414 255 HOH HOH B . 
E 3 HOH 15  415 60  HOH HOH B . 
E 3 HOH 16  416 270 HOH HOH B . 
E 3 HOH 17  417 81  HOH HOH B . 
E 3 HOH 18  418 54  HOH HOH B . 
E 3 HOH 19  419 222 HOH HOH B . 
E 3 HOH 20  420 260 HOH HOH B . 
E 3 HOH 21  421 28  HOH HOH B . 
E 3 HOH 22  422 219 HOH HOH B . 
E 3 HOH 23  423 210 HOH HOH B . 
E 3 HOH 24  424 226 HOH HOH B . 
E 3 HOH 25  425 62  HOH HOH B . 
E 3 HOH 26  426 302 HOH HOH B . 
E 3 HOH 27  427 234 HOH HOH B . 
E 3 HOH 28  428 106 HOH HOH B . 
E 3 HOH 29  429 228 HOH HOH B . 
E 3 HOH 30  430 42  HOH HOH B . 
E 3 HOH 31  431 90  HOH HOH B . 
E 3 HOH 32  432 312 HOH HOH B . 
E 3 HOH 33  433 108 HOH HOH B . 
E 3 HOH 34  434 220 HOH HOH B . 
E 3 HOH 35  435 190 HOH HOH B . 
E 3 HOH 36  436 288 HOH HOH B . 
E 3 HOH 37  437 39  HOH HOH B . 
E 3 HOH 38  438 135 HOH HOH B . 
E 3 HOH 39  439 345 HOH HOH B . 
E 3 HOH 40  440 83  HOH HOH B . 
E 3 HOH 41  441 285 HOH HOH B . 
E 3 HOH 42  442 153 HOH HOH B . 
E 3 HOH 43  443 30  HOH HOH B . 
E 3 HOH 44  444 290 HOH HOH B . 
E 3 HOH 45  445 123 HOH HOH B . 
E 3 HOH 46  446 293 HOH HOH B . 
E 3 HOH 47  447 7   HOH HOH B . 
E 3 HOH 48  448 34  HOH HOH B . 
E 3 HOH 49  449 87  HOH HOH B . 
E 3 HOH 50  450 101 HOH HOH B . 
E 3 HOH 51  451 92  HOH HOH B . 
E 3 HOH 52  452 200 HOH HOH B . 
E 3 HOH 53  453 370 HOH HOH B . 
E 3 HOH 54  454 107 HOH HOH B . 
E 3 HOH 55  455 80  HOH HOH B . 
E 3 HOH 56  456 307 HOH HOH B . 
E 3 HOH 57  457 163 HOH HOH B . 
E 3 HOH 58  458 212 HOH HOH B . 
E 3 HOH 59  459 17  HOH HOH B . 
E 3 HOH 60  460 314 HOH HOH B . 
E 3 HOH 61  461 114 HOH HOH B . 
E 3 HOH 62  462 64  HOH HOH B . 
E 3 HOH 63  463 57  HOH HOH B . 
E 3 HOH 64  464 31  HOH HOH B . 
E 3 HOH 65  465 376 HOH HOH B . 
E 3 HOH 66  466 74  HOH HOH B . 
E 3 HOH 67  467 61  HOH HOH B . 
E 3 HOH 68  468 72  HOH HOH B . 
E 3 HOH 69  469 86  HOH HOH B . 
E 3 HOH 70  470 371 HOH HOH B . 
E 3 HOH 71  471 20  HOH HOH B . 
E 3 HOH 72  472 248 HOH HOH B . 
E 3 HOH 73  473 9   HOH HOH B . 
E 3 HOH 74  474 59  HOH HOH B . 
E 3 HOH 75  475 216 HOH HOH B . 
E 3 HOH 76  476 167 HOH HOH B . 
E 3 HOH 77  477 199 HOH HOH B . 
E 3 HOH 78  478 144 HOH HOH B . 
E 3 HOH 79  479 18  HOH HOH B . 
E 3 HOH 80  480 269 HOH HOH B . 
E 3 HOH 81  481 268 HOH HOH B . 
E 3 HOH 82  482 271 HOH HOH B . 
E 3 HOH 83  483 1   HOH HOH B . 
E 3 HOH 84  484 26  HOH HOH B . 
E 3 HOH 85  485 351 HOH HOH B . 
E 3 HOH 86  486 73  HOH HOH B . 
E 3 HOH 87  487 52  HOH HOH B . 
E 3 HOH 88  488 143 HOH HOH B . 
E 3 HOH 89  489 204 HOH HOH B . 
E 3 HOH 90  490 63  HOH HOH B . 
E 3 HOH 91  491 76  HOH HOH B . 
E 3 HOH 92  492 70  HOH HOH B . 
E 3 HOH 93  493 136 HOH HOH B . 
E 3 HOH 94  494 349 HOH HOH B . 
E 3 HOH 95  495 315 HOH HOH B . 
E 3 HOH 96  496 22  HOH HOH B . 
E 3 HOH 97  497 318 HOH HOH B . 
E 3 HOH 98  498 250 HOH HOH B . 
E 3 HOH 99  499 223 HOH HOH B . 
E 3 HOH 100 500 385 HOH HOH B . 
E 3 HOH 101 501 99  HOH HOH B . 
E 3 HOH 102 502 93  HOH HOH B . 
E 3 HOH 103 503 252 HOH HOH B . 
E 3 HOH 104 504 221 HOH HOH B . 
E 3 HOH 105 505 147 HOH HOH B . 
E 3 HOH 106 506 366 HOH HOH B . 
E 3 HOH 107 507 105 HOH HOH B . 
E 3 HOH 108 508 369 HOH HOH B . 
E 3 HOH 109 509 358 HOH HOH B . 
E 3 HOH 110 510 325 HOH HOH B . 
E 3 HOH 111 511 48  HOH HOH B . 
E 3 HOH 112 512 353 HOH HOH B . 
E 3 HOH 113 513 154 HOH HOH B . 
E 3 HOH 114 514 196 HOH HOH B . 
E 3 HOH 115 515 329 HOH HOH B . 
E 3 HOH 116 516 184 HOH HOH B . 
E 3 HOH 117 517 287 HOH HOH B . 
E 3 HOH 118 518 367 HOH HOH B . 
E 3 HOH 119 519 321 HOH HOH B . 
E 3 HOH 120 520 169 HOH HOH B . 
E 3 HOH 121 521 280 HOH HOH B . 
E 3 HOH 122 522 278 HOH HOH B . 
E 3 HOH 123 523 311 HOH HOH B . 
E 3 HOH 124 524 165 HOH HOH B . 
E 3 HOH 125 525 316 HOH HOH B . 
E 3 HOH 126 526 356 HOH HOH B . 
E 3 HOH 127 527 214 HOH HOH B . 
E 3 HOH 128 528 186 HOH HOH B . 
E 3 HOH 129 529 308 HOH HOH B . 
E 3 HOH 130 530 157 HOH HOH B . 
E 3 HOH 131 531 323 HOH HOH B . 
E 3 HOH 132 532 373 HOH HOH B . 
E 3 HOH 133 533 117 HOH HOH B . 
E 3 HOH 134 534 327 HOH HOH B . 
E 3 HOH 135 535 365 HOH HOH B . 
E 3 HOH 136 536 350 HOH HOH B . 
E 3 HOH 137 537 104 HOH HOH B . 
E 3 HOH 138 538 326 HOH HOH B . 
E 3 HOH 139 539 127 HOH HOH B . 
E 3 HOH 140 540 372 HOH HOH B . 
E 3 HOH 141 541 279 HOH HOH B . 
E 3 HOH 142 542 362 HOH HOH B . 
E 3 HOH 143 543 297 HOH HOH B . 
E 3 HOH 144 544 380 HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A GLU 47  ? CG  ? A GLU 47  CG  
2  1 Y 1 A GLU 47  ? CD  ? A GLU 47  CD  
3  1 Y 1 A GLU 47  ? OE1 ? A GLU 47  OE1 
4  1 Y 1 A GLU 47  ? OE2 ? A GLU 47  OE2 
5  1 Y 1 A ASN 72  ? CG  ? A ASN 72  CG  
6  1 Y 1 A ASN 72  ? OD1 ? A ASN 72  OD1 
7  1 Y 1 A ASN 72  ? ND2 ? A ASN 72  ND2 
8  1 Y 1 A LYS 100 ? CG  ? A LYS 100 CG  
9  1 Y 1 A LYS 100 ? CD  ? A LYS 100 CD  
10 1 Y 1 A LYS 100 ? CE  ? A LYS 100 CE  
11 1 Y 1 A LYS 100 ? NZ  ? A LYS 100 NZ  
12 1 Y 1 A TYR 154 ? CG  ? A TYR 154 CG  
13 1 Y 1 A TYR 154 ? CD1 ? A TYR 154 CD1 
14 1 Y 1 A TYR 154 ? CD2 ? A TYR 154 CD2 
15 1 Y 1 A TYR 154 ? CE1 ? A TYR 154 CE1 
16 1 Y 1 A TYR 154 ? CE2 ? A TYR 154 CE2 
17 1 Y 1 A TYR 154 ? CZ  ? A TYR 154 CZ  
18 1 Y 1 A TYR 154 ? OH  ? A TYR 154 OH  
19 1 Y 1 A ARG 222 ? CG  ? A ARG 222 CG  
20 1 Y 1 A ARG 222 ? CD  ? A ARG 222 CD  
21 1 Y 1 A ARG 222 ? NE  ? A ARG 222 NE  
22 1 Y 1 A ARG 222 ? CZ  ? A ARG 222 CZ  
23 1 Y 1 A ARG 222 ? NH1 ? A ARG 222 NH1 
24 1 Y 1 A ARG 222 ? NH2 ? A ARG 222 NH2 
25 1 Y 1 B GLU 47  ? CG  ? B GLU 47  CG  
26 1 Y 1 B GLU 47  ? CD  ? B GLU 47  CD  
27 1 Y 1 B GLU 47  ? OE1 ? B GLU 47  OE1 
28 1 Y 1 B GLU 47  ? OE2 ? B GLU 47  OE2 
29 1 Y 1 B ARG 60  ? CG  ? B ARG 60  CG  
30 1 Y 1 B ARG 60  ? CD  ? B ARG 60  CD  
31 1 Y 1 B ARG 60  ? NE  ? B ARG 60  NE  
32 1 Y 1 B ARG 60  ? CZ  ? B ARG 60  CZ  
33 1 Y 1 B ARG 60  ? NH1 ? B ARG 60  NH1 
34 1 Y 1 B ARG 60  ? NH2 ? B ARG 60  NH2 
35 1 Y 1 B GLN 74  ? CG  ? B GLN 74  CG  
36 1 Y 1 B GLN 74  ? CD  ? B GLN 74  CD  
37 1 Y 1 B GLN 74  ? OE1 ? B GLN 74  OE1 
38 1 Y 1 B GLN 74  ? NE2 ? B GLN 74  NE2 
39 1 Y 1 B MET 235 ? CG  ? B MET 235 CG  
40 1 Y 1 B MET 235 ? SD  ? B MET 235 SD  
41 1 Y 1 B MET 235 ? CE  ? B MET 235 CE  
42 1 Y 1 B LYS 236 ? CG  ? B LYS 236 CG  
43 1 Y 1 B LYS 236 ? CD  ? B LYS 236 CD  
44 1 Y 1 B LYS 236 ? CE  ? B LYS 236 CE  
45 1 Y 1 B LYS 236 ? NZ  ? B LYS 236 NZ  
46 1 Y 1 B ASP 245 ? CG  ? B ASP 245 CG  
47 1 Y 1 B ASP 245 ? OD1 ? B ASP 245 OD1 
48 1 Y 1 B ASP 245 ? OD2 ? B ASP 245 OD2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BO1 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     68.006 
_cell.length_a_esd                 ? 
_cell.length_b                     100.111 
_cell.length_b_esd                 ? 
_cell.length_c                     104.136 
_cell.length_c_esd                 ? 
_cell.volume                       708973.369 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BO1 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BO1 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.62 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          53.04 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M BIS-TRIS, 20% w/v Polyethylene glycol 1,500' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            294 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-01-27 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.920105 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSLS-II BEAMLINE 17-ID-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.920105 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   17-ID-1 
_diffrn_source.pdbx_synchrotron_site       NSLS-II 
# 
_reflns.B_iso_Wilson_estimate                          26.06 
_reflns.entry_id                                       9BO1 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.96 
_reflns.d_resolution_low                               52.07 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     51418 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.72 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                13.2 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          7.31 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.994 
_reflns.pdbx_CC_star                                   0.999 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.96 
_reflns_shell.d_res_low                                     2.03 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           0.99 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             4942 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               13.6 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.461 
_reflns_shell.pdbx_CC_star                                  0.794 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          98.02 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               29.72 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9BO1 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.96 
_refine.ls_d_res_low                             52.07 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     51288 
_refine.ls_number_reflns_R_free                  2513 
_refine.ls_number_reflns_R_work                  48775 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.72 
_refine.ls_percent_reflns_R_free                 4.90 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2088 
_refine.ls_R_factor_R_free                       0.2475 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2069 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.33 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 25.0106 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2872 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.96 
_refine_hist.d_res_low                        52.07 
_refine_hist.number_atoms_solvent             347 
_refine_hist.number_atoms_total               5027 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4641 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         39 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0050  ? 4839 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.7312  ? 6600 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0463  ? 745  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0060  ? 856  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 12.8738 ? 1715 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.96 2.00  . . 134 2593 96.81  . . . . 0.3327 . . . . . . . . . . . 0.3670 
'X-RAY DIFFRACTION' 2.00 2.04  . . 168 2634 99.57  . . . . 0.3143 . . . . . . . . . . . 0.3464 
'X-RAY DIFFRACTION' 2.04 2.09  . . 163 2642 99.72  . . . . 0.2932 . . . . . . . . . . . 0.3143 
'X-RAY DIFFRACTION' 2.09 2.14  . . 153 2652 99.89  . . . . 0.2746 . . . . . . . . . . . 0.3084 
'X-RAY DIFFRACTION' 2.14 2.19  . . 123 2704 99.93  . . . . 0.2549 . . . . . . . . . . . 0.3081 
'X-RAY DIFFRACTION' 2.19 2.25  . . 128 2698 99.89  . . . . 0.2438 . . . . . . . . . . . 0.2989 
'X-RAY DIFFRACTION' 2.25 2.31  . . 145 2680 99.96  . . . . 0.2384 . . . . . . . . . . . 0.2802 
'X-RAY DIFFRACTION' 2.31 2.39  . . 154 2666 99.96  . . . . 0.2259 . . . . . . . . . . . 0.2883 
'X-RAY DIFFRACTION' 2.39 2.47  . . 135 2686 99.96  . . . . 0.2296 . . . . . . . . . . . 0.2511 
'X-RAY DIFFRACTION' 2.47 2.57  . . 137 2709 100.00 . . . . 0.2139 . . . . . . . . . . . 0.2917 
'X-RAY DIFFRACTION' 2.57 2.69  . . 124 2721 99.89  . . . . 0.2237 . . . . . . . . . . . 0.2517 
'X-RAY DIFFRACTION' 2.69 2.83  . . 111 2747 99.90  . . . . 0.2176 . . . . . . . . . . . 0.2594 
'X-RAY DIFFRACTION' 2.83 3.01  . . 126 2733 100.00 . . . . 0.2064 . . . . . . . . . . . 0.2652 
'X-RAY DIFFRACTION' 3.01 3.24  . . 128 2739 100.00 . . . . 0.1997 . . . . . . . . . . . 0.2272 
'X-RAY DIFFRACTION' 3.24 3.57  . . 136 2740 99.90  . . . . 0.1820 . . . . . . . . . . . 0.2038 
'X-RAY DIFFRACTION' 3.57 4.08  . . 161 2716 100.00 . . . . 0.1689 . . . . . . . . . . . 0.2210 
'X-RAY DIFFRACTION' 4.08 5.15  . . 129 2812 100.00 . . . . 0.1543 . . . . . . . . . . . 0.1977 
'X-RAY DIFFRACTION' 5.15 52.07 . . 158 2903 99.67  . . . . 0.1953 . . . . . . . . . . . 0.2090 
# 
_struct.entry_id                     9BO1 
_struct.title                        'Crystal Structure of T190I SARS-CoV-2 Main Protease in Complex with Compound Mpro61' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BO1 
_struct_keywords.text            'Hydrolase, VIRAL PROTEIN' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1AB_SARS2 
_struct_ref.pdbx_db_accession          P0DTD1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_struct_ref.pdbx_align_begin           3264 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9BO1 A 1 ? 306 ? P0DTD1 3264 ? 3569 ? 1 306 
2 1 9BO1 B 1 ? 306 ? P0DTD1 3264 ? 3569 ? 1 306 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9BO1 ILE A 190 ? UNP P0DTD1 THR 3453 conflict 190 1 
2 9BO1 ILE B 190 ? UNP P0DTD1 THR 3453 conflict 190 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2850  ? 
1 MORE         -13   ? 
1 'SSA (A^2)'  24740 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 10  ? GLY A 15  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 41  ? CYS A 44  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 THR A 45  ? MET A 49  ? THR A 45  MET A 49  5 ? 5  
HELX_P HELX_P4  AA4 ASN A 53  ? ARG A 60  ? ASN A 53  ARG A 60  1 ? 8  
HELX_P HELX_P5  AA5 SER A 62  ? HIS A 64  ? SER A 62  HIS A 64  5 ? 3  
HELX_P HELX_P6  AA6 ILE A 200 ? ASN A 214 ? ILE A 200 ASN A 214 1 ? 15 
HELX_P HELX_P7  AA7 THR A 226 ? MET A 235 ? THR A 226 MET A 235 1 ? 10 
HELX_P HELX_P8  AA8 LYS A 236 ? ASN A 238 ? LYS A 236 ASN A 238 5 ? 3  
HELX_P HELX_P9  AA9 THR A 243 ? LEU A 250 ? THR A 243 LEU A 250 1 ? 8  
HELX_P HELX_P10 AB1 LEU A 250 ? GLY A 258 ? LEU A 250 GLY A 258 1 ? 9  
HELX_P HELX_P11 AB2 ALA A 260 ? GLY A 275 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P12 AB3 THR A 292 ? SER A 301 ? THR A 292 SER A 301 1 ? 10 
HELX_P HELX_P13 AB4 SER B 10  ? GLY B 15  ? SER B 10  GLY B 15  1 ? 6  
HELX_P HELX_P14 AB5 HIS B 41  ? CYS B 44  ? HIS B 41  CYS B 44  5 ? 4  
HELX_P HELX_P15 AB6 GLU B 47  ? ASN B 51  ? GLU B 47  ASN B 51  5 ? 5  
HELX_P HELX_P16 AB7 ASN B 53  ? ARG B 60  ? ASN B 53  ARG B 60  1 ? 8  
HELX_P HELX_P17 AB8 SER B 62  ? PHE B 66  ? SER B 62  PHE B 66  5 ? 5  
HELX_P HELX_P18 AB9 ILE B 200 ? ASN B 214 ? ILE B 200 ASN B 214 1 ? 15 
HELX_P HELX_P19 AC1 THR B 226 ? TYR B 237 ? THR B 226 TYR B 237 1 ? 12 
HELX_P HELX_P20 AC2 THR B 243 ? LEU B 250 ? THR B 243 LEU B 250 1 ? 8  
HELX_P HELX_P21 AC3 LEU B 250 ? GLY B 258 ? LEU B 250 GLY B 258 1 ? 9  
HELX_P HELX_P22 AC4 ALA B 260 ? GLY B 275 ? ALA B 260 GLY B 275 1 ? 16 
HELX_P HELX_P23 AC5 THR B 292 ? GLY B 302 ? THR B 292 GLY B 302 1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
AA4 ? 7 ? 
AA5 ? 5 ? 
AA6 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA4 5 6 ? anti-parallel 
AA4 6 7 ? anti-parallel 
AA5 1 2 ? parallel      
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA5 4 5 ? anti-parallel 
AA6 1 2 ? parallel      
AA6 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 73  ? LEU A 75  ? VAL A 73  LEU A 75  
AA1 2 PHE A 66  ? ALA A 70  ? PHE A 66  ALA A 70  
AA1 3 MET A 17  ? CYS A 22  ? MET A 17  CYS A 22  
AA1 4 THR A 25  ? LEU A 32  ? THR A 25  LEU A 32  
AA1 5 VAL A 35  ? PRO A 39  ? VAL A 35  PRO A 39  
AA1 6 VAL A 86  ? VAL A 91  ? VAL A 86  VAL A 91  
AA1 7 VAL A 77  ? GLN A 83  ? VAL A 77  GLN A 83  
AA2 1 LYS A 100 ? PHE A 103 ? LYS A 100 PHE A 103 
AA2 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA2 3 VAL A 148 ? ASP A 153 ? VAL A 148 ASP A 153 
AA2 4 THR A 111 ? TYR A 118 ? THR A 111 TYR A 118 
AA2 5 SER A 121 ? ALA A 129 ? SER A 121 ALA A 129 
AA3 1 LYS A 100 ? PHE A 103 ? LYS A 100 PHE A 103 
AA3 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA3 3 HIS A 172 ? THR A 175 ? HIS A 172 THR A 175 
AA4 1 VAL B 73  ? LEU B 75  ? VAL B 73  LEU B 75  
AA4 2 LEU B 67  ? ALA B 70  ? LEU B 67  ALA B 70  
AA4 3 MET B 17  ? CYS B 22  ? MET B 17  CYS B 22  
AA4 4 THR B 25  ? LEU B 32  ? THR B 25  LEU B 32  
AA4 5 VAL B 35  ? PRO B 39  ? VAL B 35  PRO B 39  
AA4 6 VAL B 86  ? VAL B 91  ? VAL B 86  VAL B 91  
AA4 7 VAL B 77  ? GLN B 83  ? VAL B 77  GLN B 83  
AA5 1 TYR B 101 ? PHE B 103 ? TYR B 101 PHE B 103 
AA5 2 CYS B 156 ? GLU B 166 ? CYS B 156 GLU B 166 
AA5 3 VAL B 148 ? ASP B 153 ? VAL B 148 ASP B 153 
AA5 4 THR B 111 ? TYR B 118 ? THR B 111 TYR B 118 
AA5 5 SER B 121 ? ALA B 129 ? SER B 121 ALA B 129 
AA6 1 TYR B 101 ? PHE B 103 ? TYR B 101 PHE B 103 
AA6 2 CYS B 156 ? GLU B 166 ? CYS B 156 GLU B 166 
AA6 3 HIS B 172 ? THR B 175 ? HIS B 172 THR B 175 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL A 73  ? O VAL A 73  N ALA A 70  ? N ALA A 70  
AA1 2 3 O LEU A 67  ? O LEU A 67  N THR A 21  ? N THR A 21  
AA1 3 4 N VAL A 20  ? N VAL A 20  O LEU A 27  ? O LEU A 27  
AA1 4 5 N LEU A 30  ? N LEU A 30  O TYR A 37  ? O TYR A 37  
AA1 5 6 N VAL A 36  ? N VAL A 36  O LEU A 89  ? O LEU A 89  
AA1 6 7 O LYS A 90  ? O LYS A 90  N GLY A 79  ? N GLY A 79  
AA2 1 2 N LYS A 100 ? N LYS A 100 O VAL A 157 ? O VAL A 157 
AA2 2 3 O SER A 158 ? O SER A 158 N ASN A 151 ? N ASN A 151 
AA2 3 4 O PHE A 150 ? O PHE A 150 N SER A 113 ? N SER A 113 
AA2 4 5 N ALA A 116 ? N ALA A 116 O SER A 123 ? O SER A 123 
AA3 1 2 N LYS A 100 ? N LYS A 100 O VAL A 157 ? O VAL A 157 
AA3 2 3 N MET A 165 ? N MET A 165 O ALA A 173 ? O ALA A 173 
AA4 1 2 O LEU B 75  ? O LEU B 75  N VAL B 68  ? N VAL B 68  
AA4 2 3 O LEU B 67  ? O LEU B 67  N THR B 21  ? N THR B 21  
AA4 3 4 N VAL B 18  ? N VAL B 18  O GLY B 29  ? O GLY B 29  
AA4 4 5 N LEU B 30  ? N LEU B 30  O TYR B 37  ? O TYR B 37  
AA4 5 6 N CYS B 38  ? N CYS B 38  O LEU B 87  ? O LEU B 87  
AA4 6 7 O LYS B 88  ? O LYS B 88  N SER B 81  ? N SER B 81  
AA5 1 2 N LYS B 102 ? N LYS B 102 O VAL B 157 ? O VAL B 157 
AA5 2 3 O SER B 158 ? O SER B 158 N ASN B 151 ? N ASN B 151 
AA5 3 4 O PHE B 150 ? O PHE B 150 N SER B 113 ? N SER B 113 
AA5 4 5 N VAL B 114 ? N VAL B 114 O TYR B 126 ? O TYR B 126 
AA6 1 2 N LYS B 102 ? N LYS B 102 O VAL B 157 ? O VAL B 157 
AA6 2 3 N MET B 165 ? N MET B 165 O ALA B 173 ? O ALA B 173 
# 
_pdbx_entry_details.entry_id                   9BO1 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 33  ? ? 51.78   -127.31 
2 1 HIS A 41  ? ? -68.72  3.00    
3 1 ASN A 84  ? ? 50.31   -121.62 
4 1 TYR A 154 ? ? 59.24   -114.76 
5 1 GLN A 189 ? ? -86.34  39.67   
6 1 ASP B 33  ? ? 48.05   -127.95 
7 1 ASN B 51  ? ? -159.03 73.38   
8 1 ASN B 84  ? ? 52.27   -130.00 
9 1 TYR B 154 ? ? 61.36   -108.48 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 703 ? 6.57 . 
2 1 O ? B HOH 544 ? 6.39 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A GLY 302 ? A GLY 302 
2 1 Y 1 A VAL 303 ? A VAL 303 
3 1 Y 1 A THR 304 ? A THR 304 
4 1 Y 1 A PHE 305 ? A PHE 305 
5 1 Y 1 A GLN 306 ? A GLN 306 
6 1 Y 1 B GLN 306 ? B GLN 306 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
GLN N    N  N N 88  
GLN CA   C  N S 89  
GLN C    C  N N 90  
GLN O    O  N N 91  
GLN CB   C  N N 92  
GLN CG   C  N N 93  
GLN CD   C  N N 94  
GLN OE1  O  N N 95  
GLN NE2  N  N N 96  
GLN OXT  O  N N 97  
GLN H    H  N N 98  
GLN H2   H  N N 99  
GLN HA   H  N N 100 
GLN HB2  H  N N 101 
GLN HB3  H  N N 102 
GLN HG2  H  N N 103 
GLN HG3  H  N N 104 
GLN HE21 H  N N 105 
GLN HE22 H  N N 106 
GLN HXT  H  N N 107 
GLU N    N  N N 108 
GLU CA   C  N S 109 
GLU C    C  N N 110 
GLU O    O  N N 111 
GLU CB   C  N N 112 
GLU CG   C  N N 113 
GLU CD   C  N N 114 
GLU OE1  O  N N 115 
GLU OE2  O  N N 116 
GLU OXT  O  N N 117 
GLU H    H  N N 118 
GLU H2   H  N N 119 
GLU HA   H  N N 120 
GLU HB2  H  N N 121 
GLU HB3  H  N N 122 
GLU HG2  H  N N 123 
GLU HG3  H  N N 124 
GLU HE2  H  N N 125 
GLU HXT  H  N N 126 
GLY N    N  N N 127 
GLY CA   C  N N 128 
GLY C    C  N N 129 
GLY O    O  N N 130 
GLY OXT  O  N N 131 
GLY H    H  N N 132 
GLY H2   H  N N 133 
GLY HA2  H  N N 134 
GLY HA3  H  N N 135 
GLY HXT  H  N N 136 
HIS N    N  N N 137 
HIS CA   C  N S 138 
HIS C    C  N N 139 
HIS O    O  N N 140 
HIS CB   C  N N 141 
HIS CG   C  Y N 142 
HIS ND1  N  Y N 143 
HIS CD2  C  Y N 144 
HIS CE1  C  Y N 145 
HIS NE2  N  Y N 146 
HIS OXT  O  N N 147 
HIS H    H  N N 148 
HIS H2   H  N N 149 
HIS HA   H  N N 150 
HIS HB2  H  N N 151 
HIS HB3  H  N N 152 
HIS HD1  H  N N 153 
HIS HD2  H  N N 154 
HIS HE1  H  N N 155 
HIS HE2  H  N N 156 
HIS HXT  H  N N 157 
HOH O    O  N N 158 
HOH H1   H  N N 159 
HOH H2   H  N N 160 
ILE N    N  N N 161 
ILE CA   C  N S 162 
ILE C    C  N N 163 
ILE O    O  N N 164 
ILE CB   C  N S 165 
ILE CG1  C  N N 166 
ILE CG2  C  N N 167 
ILE CD1  C  N N 168 
ILE OXT  O  N N 169 
ILE H    H  N N 170 
ILE H2   H  N N 171 
ILE HA   H  N N 172 
ILE HB   H  N N 173 
ILE HG12 H  N N 174 
ILE HG13 H  N N 175 
ILE HG21 H  N N 176 
ILE HG22 H  N N 177 
ILE HG23 H  N N 178 
ILE HD11 H  N N 179 
ILE HD12 H  N N 180 
ILE HD13 H  N N 181 
ILE HXT  H  N N 182 
LEU N    N  N N 183 
LEU CA   C  N S 184 
LEU C    C  N N 185 
LEU O    O  N N 186 
LEU CB   C  N N 187 
LEU CG   C  N N 188 
LEU CD1  C  N N 189 
LEU CD2  C  N N 190 
LEU OXT  O  N N 191 
LEU H    H  N N 192 
LEU H2   H  N N 193 
LEU HA   H  N N 194 
LEU HB2  H  N N 195 
LEU HB3  H  N N 196 
LEU HG   H  N N 197 
LEU HD11 H  N N 198 
LEU HD12 H  N N 199 
LEU HD13 H  N N 200 
LEU HD21 H  N N 201 
LEU HD22 H  N N 202 
LEU HD23 H  N N 203 
LEU HXT  H  N N 204 
LYS N    N  N N 205 
LYS CA   C  N S 206 
LYS C    C  N N 207 
LYS O    O  N N 208 
LYS CB   C  N N 209 
LYS CG   C  N N 210 
LYS CD   C  N N 211 
LYS CE   C  N N 212 
LYS NZ   N  N N 213 
LYS OXT  O  N N 214 
LYS H    H  N N 215 
LYS H2   H  N N 216 
LYS HA   H  N N 217 
LYS HB2  H  N N 218 
LYS HB3  H  N N 219 
LYS HG2  H  N N 220 
LYS HG3  H  N N 221 
LYS HD2  H  N N 222 
LYS HD3  H  N N 223 
LYS HE2  H  N N 224 
LYS HE3  H  N N 225 
LYS HZ1  H  N N 226 
LYS HZ2  H  N N 227 
LYS HZ3  H  N N 228 
LYS HXT  H  N N 229 
MET N    N  N N 230 
MET CA   C  N S 231 
MET C    C  N N 232 
MET O    O  N N 233 
MET CB   C  N N 234 
MET CG   C  N N 235 
MET SD   S  N N 236 
MET CE   C  N N 237 
MET OXT  O  N N 238 
MET H    H  N N 239 
MET H2   H  N N 240 
MET HA   H  N N 241 
MET HB2  H  N N 242 
MET HB3  H  N N 243 
MET HG2  H  N N 244 
MET HG3  H  N N 245 
MET HE1  H  N N 246 
MET HE2  H  N N 247 
MET HE3  H  N N 248 
MET HXT  H  N N 249 
PHE N    N  N N 250 
PHE CA   C  N S 251 
PHE C    C  N N 252 
PHE O    O  N N 253 
PHE CB   C  N N 254 
PHE CG   C  Y N 255 
PHE CD1  C  Y N 256 
PHE CD2  C  Y N 257 
PHE CE1  C  Y N 258 
PHE CE2  C  Y N 259 
PHE CZ   C  Y N 260 
PHE OXT  O  N N 261 
PHE H    H  N N 262 
PHE H2   H  N N 263 
PHE HA   H  N N 264 
PHE HB2  H  N N 265 
PHE HB3  H  N N 266 
PHE HD1  H  N N 267 
PHE HD2  H  N N 268 
PHE HE1  H  N N 269 
PHE HE2  H  N N 270 
PHE HZ   H  N N 271 
PHE HXT  H  N N 272 
PRO N    N  N N 273 
PRO CA   C  N S 274 
PRO C    C  N N 275 
PRO O    O  N N 276 
PRO CB   C  N N 277 
PRO CG   C  N N 278 
PRO CD   C  N N 279 
PRO OXT  O  N N 280 
PRO H    H  N N 281 
PRO HA   H  N N 282 
PRO HB2  H  N N 283 
PRO HB3  H  N N 284 
PRO HG2  H  N N 285 
PRO HG3  H  N N 286 
PRO HD2  H  N N 287 
PRO HD3  H  N N 288 
PRO HXT  H  N N 289 
SER N    N  N N 290 
SER CA   C  N S 291 
SER C    C  N N 292 
SER O    O  N N 293 
SER CB   C  N N 294 
SER OG   O  N N 295 
SER OXT  O  N N 296 
SER H    H  N N 297 
SER H2   H  N N 298 
SER HA   H  N N 299 
SER HB2  H  N N 300 
SER HB3  H  N N 301 
SER HG   H  N N 302 
SER HXT  H  N N 303 
THR N    N  N N 304 
THR CA   C  N S 305 
THR C    C  N N 306 
THR O    O  N N 307 
THR CB   C  N R 308 
THR OG1  O  N N 309 
THR CG2  C  N N 310 
THR OXT  O  N N 311 
THR H    H  N N 312 
THR H2   H  N N 313 
THR HA   H  N N 314 
THR HB   H  N N 315 
THR HG1  H  N N 316 
THR HG21 H  N N 317 
THR HG22 H  N N 318 
THR HG23 H  N N 319 
THR HXT  H  N N 320 
TRP N    N  N N 321 
TRP CA   C  N S 322 
TRP C    C  N N 323 
TRP O    O  N N 324 
TRP CB   C  N N 325 
TRP CG   C  Y N 326 
TRP CD1  C  Y N 327 
TRP CD2  C  Y N 328 
TRP NE1  N  Y N 329 
TRP CE2  C  Y N 330 
TRP CE3  C  Y N 331 
TRP CZ2  C  Y N 332 
TRP CZ3  C  Y N 333 
TRP CH2  C  Y N 334 
TRP OXT  O  N N 335 
TRP H    H  N N 336 
TRP H2   H  N N 337 
TRP HA   H  N N 338 
TRP HB2  H  N N 339 
TRP HB3  H  N N 340 
TRP HD1  H  N N 341 
TRP HE1  H  N N 342 
TRP HE3  H  N N 343 
TRP HZ2  H  N N 344 
TRP HZ3  H  N N 345 
TRP HH2  H  N N 346 
TRP HXT  H  N N 347 
TYR N    N  N N 348 
TYR CA   C  N S 349 
TYR C    C  N N 350 
TYR O    O  N N 351 
TYR CB   C  N N 352 
TYR CG   C  Y N 353 
TYR CD1  C  Y N 354 
TYR CD2  C  Y N 355 
TYR CE1  C  Y N 356 
TYR CE2  C  Y N 357 
TYR CZ   C  Y N 358 
TYR OH   O  N N 359 
TYR OXT  O  N N 360 
TYR H    H  N N 361 
TYR H2   H  N N 362 
TYR HA   H  N N 363 
TYR HB2  H  N N 364 
TYR HB3  H  N N 365 
TYR HD1  H  N N 366 
TYR HD2  H  N N 367 
TYR HE1  H  N N 368 
TYR HE2  H  N N 369 
TYR HH   H  N N 370 
TYR HXT  H  N N 371 
VAL N    N  N N 372 
VAL CA   C  N S 373 
VAL C    C  N N 374 
VAL O    O  N N 375 
VAL CB   C  N N 376 
VAL CG1  C  N N 377 
VAL CG2  C  N N 378 
VAL OXT  O  N N 379 
VAL H    H  N N 380 
VAL H2   H  N N 381 
VAL HA   H  N N 382 
VAL HB   H  N N 383 
VAL HG11 H  N N 384 
VAL HG12 H  N N 385 
VAL HG13 H  N N 386 
VAL HG21 H  N N 387 
VAL HG22 H  N N 388 
VAL HG23 H  N N 389 
VAL HXT  H  N N 390 
XEK C1   C  N N 391 
XEK C2   C  N N 392 
XEK C3   C  Y N 393 
XEK C4   C  Y N 394 
XEK C5   C  Y N 395 
XEK C6   C  Y N 396 
XEK C7   C  Y N 397 
XEK C8   C  N N 398 
XEK C9   C  Y N 399 
XEK C10  C  Y N 400 
XEK C11  C  Y N 401 
XEK C12  C  Y N 402 
XEK C13  C  Y N 403 
XEK C14  C  Y N 404 
XEK C15  C  Y N 405 
XEK C17  C  N N 406 
XEK C21  C  N N 407 
XEK C22  C  N N 408 
XEK C24  C  Y N 409 
XEK C25  C  Y N 410 
XEK C27  C  Y N 411 
XEK C16  C  N N 412 
XEK C18  C  N N 413 
XEK C19  C  N N 414 
XEK C20  C  N N 415 
XEK C23  C  N N 416 
XEK C26  C  Y N 417 
XEK C28  C  Y N 418 
XEK F1   F  N N 419 
XEK N1   N  N N 420 
XEK N2   N  N N 421 
XEK N3   N  N N 422 
XEK N4   N  Y N 423 
XEK O1   O  N N 424 
XEK O2   O  N N 425 
XEK O3   O  N N 426 
XEK O4   O  N N 427 
XEK CL1  CL N N 428 
XEK CL2  CL N N 429 
XEK H1   H  N N 430 
XEK H2   H  N N 431 
XEK H3   H  N N 432 
XEK H4   H  N N 433 
XEK H5   H  N N 434 
XEK H6   H  N N 435 
XEK H7   H  N N 436 
XEK H8   H  N N 437 
XEK H13  H  N N 438 
XEK H14  H  N N 439 
XEK H12  H  N N 440 
XEK H16  H  N N 441 
XEK H18  H  N N 442 
XEK H9   H  N N 443 
XEK H11  H  N N 444 
XEK H15  H  N N 445 
XEK H17  H  N N 446 
XEK H19  H  N N 447 
XEK H10  H  N N 448 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
XEK O1  C1   doub N N 376 
XEK C1  C2   sing N N 377 
XEK C1  N3   sing N N 378 
XEK C2  C3   sing N N 379 
XEK C2  C16  doub N N 380 
XEK C3  C4   doub Y N 381 
XEK C3  C15  sing Y N 382 
XEK C4  C5   sing Y N 383 
XEK C5  CL1  sing N N 384 
XEK C5  C6   doub Y N 385 
XEK C6  F1   sing N N 386 
XEK C6  C7   sing Y N 387 
XEK C7  O2   sing N N 388 
XEK C7  C15  doub Y N 389 
XEK O2  C8   sing N N 390 
XEK C8  C9   sing N N 391 
XEK C9  C10  doub Y N 392 
XEK C9  C14  sing Y N 393 
XEK C10 C11  sing Y N 394 
XEK C11 C12  doub Y N 395 
XEK C12 C13  sing Y N 396 
XEK C13 C14  doub Y N 397 
XEK C14 CL2  sing N N 398 
XEK C16 C17  sing N N 399 
XEK C17 C18  sing N N 400 
XEK C17 C23  doub N N 401 
XEK C18 C19  sing N N 402 
XEK C18 C20  doub N N 403 
XEK C19 N1   sing N N 404 
XEK C19 O3   doub N N 405 
XEK N1  C22  sing N N 406 
XEK C20 N2   sing N N 407 
XEK N2  C21  sing N N 408 
XEK N2  C22  sing N N 409 
XEK C22 O4   doub N N 410 
XEK C23 N3   sing N N 411 
XEK N3  C24  sing N N 412 
XEK C24 C25  doub Y N 413 
XEK C24 C28  sing Y N 414 
XEK C25 C26  sing Y N 415 
XEK C26 C27  doub Y N 416 
XEK C27 N4   sing Y N 417 
XEK N4  C28  doub Y N 418 
XEK C4  H1   sing N N 419 
XEK C8  H2   sing N N 420 
XEK C8  H3   sing N N 421 
XEK C10 H4   sing N N 422 
XEK C11 H5   sing N N 423 
XEK C12 H6   sing N N 424 
XEK C13 H7   sing N N 425 
XEK C15 H8   sing N N 426 
XEK C21 H13  sing N N 427 
XEK C21 H14  sing N N 428 
XEK C21 H12  sing N N 429 
XEK C25 H16  sing N N 430 
XEK C27 H18  sing N N 431 
XEK C16 H9   sing N N 432 
XEK C20 H11  sing N N 433 
XEK C23 H15  sing N N 434 
XEK C26 H17  sing N N 435 
XEK C28 H19  sing N N 436 
XEK N1  H10  sing N N 437 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' 'P30 GM133893' 1 
'Department of Energy (DOE, United States)'                                                'United States' KP1607011      2 
'Other government'                                                                         ?               DE-SC0012704   3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6Y2G 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9BO1 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.014705 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.009989 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009603 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
CL ? ? 9.50761 7.44341 ? ? 1.04373  23.83732 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
F  ? ? 4.90428 4.07044 ? ? 12.99538 1.63651  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . SER A 1 1   ? 13.88467  9.50159   -12.51210 1.000 41.17196 ? 1   SER A N   1 
ATOM   2    C  CA  . SER A 1 1   ? 14.04911  8.73529   -13.73719 1.000 44.47513 ? 1   SER A CA  1 
ATOM   3    C  C   . SER A 1 1   ? 13.01004  7.62292   -13.82195 1.000 44.47655 ? 1   SER A C   1 
ATOM   4    O  O   . SER A 1 1   ? 12.08629  7.55927   -13.00984 1.000 40.98659 ? 1   SER A O   1 
ATOM   5    C  CB  . SER A 1 1   ? 15.45799  8.14877   -13.81708 1.000 50.27388 ? 1   SER A CB  1 
ATOM   6    O  OG  . SER A 1 1   ? 15.63291  7.15155   -12.82767 1.000 55.03589 ? 1   SER A OG  1 
ATOM   7    N  N   . GLY A 1 2   ? 13.18299  6.73726   -14.79735 1.000 43.83958 ? 2   GLY A N   1 
ATOM   8    C  CA  . GLY A 1 2   ? 12.19326  5.73491   -15.12539 1.000 37.41994 ? 2   GLY A CA  1 
ATOM   9    C  C   . GLY A 1 2   ? 11.17449  6.25843   -16.12235 1.000 36.50214 ? 2   GLY A C   1 
ATOM   10   O  O   . GLY A 1 2   ? 10.94813  7.45905   -16.25518 1.000 38.88426 ? 2   GLY A O   1 
ATOM   11   N  N   . PHE A 1 3   ? 10.55867  5.32835   -16.84707 1.000 37.07184 ? 3   PHE A N   1 
ATOM   12   C  CA  . PHE A 1 3   ? 9.58376   5.68861   -17.87144 1.000 35.18419 ? 3   PHE A CA  1 
ATOM   13   C  C   . PHE A 1 3   ? 8.48297   4.64338   -17.89189 1.000 35.91109 ? 3   PHE A C   1 
ATOM   14   O  O   . PHE A 1 3   ? 8.73297   3.48259   -18.23003 1.000 35.13290 ? 3   PHE A O   1 
ATOM   15   C  CB  . PHE A 1 3   ? 10.23798  5.79993   -19.25231 1.000 33.55071 ? 3   PHE A CB  1 
ATOM   16   C  CG  . PHE A 1 3   ? 9.51219   6.70994   -20.18571 1.000 35.49843 ? 3   PHE A CG  1 
ATOM   17   C  CD1 . PHE A 1 3   ? 9.61602   8.08212   -20.04618 1.000 37.82905 ? 3   PHE A CD1 1 
ATOM   18   C  CD2 . PHE A 1 3   ? 8.71299   6.19944   -21.18983 1.000 30.00655 ? 3   PHE A CD2 1 
ATOM   19   C  CE1 . PHE A 1 3   ? 8.93468   8.93154   -20.89656 1.000 37.14762 ? 3   PHE A CE1 1 
ATOM   20   C  CE2 . PHE A 1 3   ? 8.03354   7.04316   -22.04247 1.000 31.97383 ? 3   PHE A CE2 1 
ATOM   21   C  CZ  . PHE A 1 3   ? 8.14421   8.41016   -21.89422 1.000 32.43999 ? 3   PHE A CZ  1 
ATOM   22   N  N   . ARG A 1 4   ? 7.27062   5.05138   -17.53640 1.000 30.02123 ? 4   ARG A N   1 
ATOM   23   C  CA  . ARG A 1 4   ? 6.13691   4.14409   -17.51165 1.000 34.20657 ? 4   ARG A CA  1 
ATOM   24   C  C   . ARG A 1 4   ? 4.98081   4.74544   -18.29861 1.000 30.65145 ? 4   ARG A C   1 
ATOM   25   O  O   . ARG A 1 4   ? 4.89969   5.95702   -18.50877 1.000 31.49785 ? 4   ARG A O   1 
ATOM   26   C  CB  . ARG A 1 4   ? 5.70393   3.82032   -16.06838 1.000 33.45874 ? 4   ARG A CB  1 
ATOM   27   C  CG  . ARG A 1 4   ? 6.83272   3.24049   -15.22459 1.000 34.18007 ? 4   ARG A CG  1 
ATOM   28   C  CD  . ARG A 1 4   ? 6.32419   2.31026   -14.14398 1.000 34.18148 ? 4   ARG A CD  1 
ATOM   29   N  NE  . ARG A 1 4   ? 5.60711   1.16836   -14.69203 1.000 40.92153 ? 4   ARG A NE  1 
ATOM   30   C  CZ  . ARG A 1 4   ? 5.87667   -0.09988  -14.41008 1.000 38.30493 ? 4   ARG A CZ  1 
ATOM   31   N  NH1 . ARG A 1 4   ? 6.83870   -0.43360  -13.56319 1.000 29.83217 ? 4   ARG A NH1 1 
ATOM   32   N  NH2 . ARG A 1 4   ? 5.15473   -1.05822  -14.98598 1.000 37.91318 ? 4   ARG A NH2 1 
ATOM   33   N  N   . LYS A 1 5   ? 4.08954   3.87358   -18.74578 1.000 31.22160 ? 5   LYS A N   1 
ATOM   34   C  CA  . LYS A 1 5   ? 2.85355   4.30009   -19.39511 1.000 32.39296 ? 5   LYS A CA  1 
ATOM   35   C  C   . LYS A 1 5   ? 1.87526   4.73165   -18.30549 1.000 29.53831 ? 5   LYS A C   1 
ATOM   36   O  O   . LYS A 1 5   ? 1.08146   3.93657   -17.79708 1.000 39.52488 ? 5   LYS A O   1 
ATOM   37   C  CB  . LYS A 1 5   ? 2.29286   3.17483   -20.25279 1.000 31.51279 ? 5   LYS A CB  1 
ATOM   38   C  CG  . LYS A 1 5   ? 1.16164   3.57816   -21.17233 1.000 30.60922 ? 5   LYS A CG  1 
ATOM   39   C  CD  . LYS A 1 5   ? 1.02220   2.56087   -22.27973 1.000 31.27687 ? 5   LYS A CD  1 
ATOM   40   C  CE  . LYS A 1 5   ? 2.23520   2.61321   -23.19143 1.000 27.49742 ? 5   LYS A CE  1 
ATOM   41   N  NZ  . LYS A 1 5   ? 2.17425   1.57028   -24.23946 1.000 32.32081 ? 5   LYS A NZ  1 
ATOM   42   N  N   . MET A 1 6   ? 1.93405   6.00934   -17.93586 1.000 28.60776 ? 6   MET A N   1 
ATOM   43   C  CA  . MET A 1 6   ? 1.07699   6.54959   -16.88694 1.000 25.98063 ? 6   MET A CA  1 
ATOM   44   C  C   . MET A 1 6   ? -0.26010  7.00034   -17.46148 1.000 22.14552 ? 6   MET A C   1 
ATOM   45   O  O   . MET A 1 6   ? -0.31714  7.60496   -18.53204 1.000 21.71978 ? 6   MET A O   1 
ATOM   46   C  CB  . MET A 1 6   ? 1.73761   7.73693   -16.18968 1.000 27.07366 ? 6   MET A CB  1 
ATOM   47   C  CG  . MET A 1 6   ? 3.02223   7.43836   -15.46062 1.000 34.84695 ? 6   MET A CG  1 
ATOM   48   S  SD  . MET A 1 6   ? 3.43283   8.83804   -14.40137 1.000 47.23040 ? 6   MET A SD  1 
ATOM   49   C  CE  . MET A 1 6   ? 2.84805   10.19347  -15.42105 1.000 33.02943 ? 6   MET A CE  1 
ATOM   50   N  N   . ALA A 1 7   ? -1.33061  6.72371   -16.73242 1.000 17.72246 ? 7   ALA A N   1 
ATOM   51   C  CA  . ALA A 1 7   ? -2.63797  7.26188   -17.06640 1.000 19.37485 ? 7   ALA A CA  1 
ATOM   52   C  C   . ALA A 1 7   ? -2.89977  8.52182   -16.24334 1.000 20.29442 ? 7   ALA A C   1 
ATOM   53   O  O   . ALA A 1 7   ? -2.18078  8.83215   -15.29479 1.000 17.64152 ? 7   ALA A O   1 
ATOM   54   C  CB  . ALA A 1 7   ? -3.72696  6.21187   -16.82586 1.000 18.82211 ? 7   ALA A CB  1 
ATOM   55   N  N   . PHE A 1 8   ? -3.93400  9.26939   -16.63119 1.000 19.15379 ? 8   PHE A N   1 
ATOM   56   C  CA  . PHE A 1 8   ? -4.29303  10.40425  -15.79133 1.000 20.05505 ? 8   PHE A CA  1 
ATOM   57   C  C   . PHE A 1 8   ? -5.00807  9.93349   -14.53218 1.000 21.02572 ? 8   PHE A C   1 
ATOM   58   O  O   . PHE A 1 8   ? -5.69013  8.90702   -14.55293 1.000 21.27323 ? 8   PHE A O   1 
ATOM   59   C  CB  . PHE A 1 8   ? -5.18786  11.37704  -16.55058 1.000 20.15847 ? 8   PHE A CB  1 
ATOM   60   C  CG  . PHE A 1 8   ? -4.43487  12.20781  -17.54429 1.000 23.58305 ? 8   PHE A CG  1 
ATOM   61   C  CD1 . PHE A 1 8   ? -3.76431  13.34509  -17.13678 1.000 24.98604 ? 8   PHE A CD1 1 
ATOM   62   C  CD2 . PHE A 1 8   ? -4.37004  11.83113  -18.87212 1.000 24.83832 ? 8   PHE A CD2 1 
ATOM   63   C  CE1 . PHE A 1 8   ? -3.05261  14.10539  -18.05046 1.000 33.23165 ? 8   PHE A CE1 1 
ATOM   64   C  CE2 . PHE A 1 8   ? -3.66157  12.59045  -19.79424 1.000 28.62364 ? 8   PHE A CE2 1 
ATOM   65   C  CZ  . PHE A 1 8   ? -3.00601  13.72633  -19.37730 1.000 28.97424 ? 8   PHE A CZ  1 
ATOM   66   N  N   . PRO A 1 9   ? -4.85942  10.66464  -13.42556 1.000 17.52049 ? 9   PRO A N   1 
ATOM   67   C  CA  . PRO A 1 9   ? -5.65875  10.36180  -12.23420 1.000 16.83909 ? 9   PRO A CA  1 
ATOM   68   C  C   . PRO A 1 9   ? -7.13403  10.39218  -12.60462 1.000 19.31287 ? 9   PRO A C   1 
ATOM   69   O  O   . PRO A 1 9   ? -7.60017  11.31980  -13.26448 1.000 22.21335 ? 9   PRO A O   1 
ATOM   70   C  CB  . PRO A 1 9   ? -5.28613  11.48590  -11.25400 1.000 17.76985 ? 9   PRO A CB  1 
ATOM   71   C  CG  . PRO A 1 9   ? -3.97719  12.03331  -11.75887 1.000 19.22707 ? 9   PRO A CG  1 
ATOM   72   C  CD  . PRO A 1 9   ? -4.04822  11.88496  -13.25560 1.000 20.60172 ? 9   PRO A CD  1 
ATOM   73   N  N   . SER A 1 10  ? -7.85571  9.34782   -12.21590 1.000 16.42007 ? 10  SER A N   1 
ATOM   74   C  CA  . SER A 1 10  ? -9.19755  9.09994   -12.72461 1.000 17.86842 ? 10  SER A CA  1 
ATOM   75   C  C   . SER A 1 10  ? -10.30306 9.73525   -11.89174 1.000 20.81816 ? 10  SER A C   1 
ATOM   76   O  O   . SER A 1 10  ? -11.46921 9.67759   -12.30582 1.000 20.45226 ? 10  SER A O   1 
ATOM   77   C  CB  . SER A 1 10  ? -9.44544  7.59247   -12.82233 1.000 18.70078 ? 10  SER A CB  1 
ATOM   78   O  OG  . SER A 1 10  ? -9.39289  6.99089   -11.53945 1.000 21.43814 ? 10  SER A OG  1 
ATOM   79   N  N   . GLY A 1 11  ? -9.96767  10.35195  -10.75469 1.000 19.12876 ? 11  GLY A N   1 
ATOM   80   C  CA  . GLY A 1 11  ? -10.99295 10.76627  -9.80684  1.000 19.59464 ? 11  GLY A CA  1 
ATOM   81   C  C   . GLY A 1 11  ? -12.06747 11.65962  -10.40238 1.000 19.14697 ? 11  GLY A C   1 
ATOM   82   O  O   . GLY A 1 11  ? -13.25330 11.48881  -10.11562 1.000 18.46497 ? 11  GLY A O   1 
ATOM   83   N  N   . LYS A 1 12  ? -11.67046 12.62627  -11.23273 1.000 20.49232 ? 12  LYS A N   1 
ATOM   84   C  CA  . LYS A 1 12  ? -12.65554 13.52760  -11.83651 1.000 23.89826 ? 12  LYS A CA  1 
ATOM   85   C  C   . LYS A 1 12  ? -13.64039 12.79046  -12.73535 1.000 22.05385 ? 12  LYS A C   1 
ATOM   86   O  O   . LYS A 1 12  ? -14.78457 13.22940  -12.88182 1.000 24.08693 ? 12  LYS A O   1 
ATOM   87   C  CB  . LYS A 1 12  ? -11.95158 14.62910  -12.62489 1.000 22.14162 ? 12  LYS A CB  1 
ATOM   88   C  CG  . LYS A 1 12  ? -11.36806 15.71690  -11.74928 1.000 27.77909 ? 12  LYS A CG  1 
ATOM   89   C  CD  . LYS A 1 12  ? -10.53679 16.68234  -12.55445 1.000 27.61292 ? 12  LYS A CD  1 
ATOM   90   C  CE  . LYS A 1 12  ? -9.89106  17.71594  -11.64016 1.000 42.82489 ? 12  LYS A CE  1 
ATOM   91   N  NZ  . LYS A 1 12  ? -9.08439  17.07628  -10.56070 1.000 41.31796 ? 12  LYS A NZ  1 
ATOM   92   N  N   . VAL A 1 13  ? -13.22914 11.67410  -13.33634 1.000 18.01330 ? 13  VAL A N   1 
ATOM   93   C  CA  . VAL A 1 13  ? -14.15481 10.92770  -14.17784 1.000 18.82047 ? 13  VAL A CA  1 
ATOM   94   C  C   . VAL A 1 13  ? -15.00432 9.98069   -13.33917 1.000 20.10774 ? 13  VAL A C   1 
ATOM   95   O  O   . VAL A 1 13  ? -16.19921 9.80316   -13.61013 1.000 19.48858 ? 13  VAL A O   1 
ATOM   96   C  CB  . VAL A 1 13  ? -13.40328 10.18147  -15.30111 1.000 18.67173 ? 13  VAL A CB  1 
ATOM   97   C  CG1 . VAL A 1 13  ? -14.41057 9.55058   -16.28597 1.000 14.68184 ? 13  VAL A CG1 1 
ATOM   98   C  CG2 . VAL A 1 13  ? -12.46778 11.13028  -16.03219 1.000 18.73384 ? 13  VAL A CG2 1 
ATOM   99   N  N   . GLU A 1 14  ? -14.40514 9.35749   -12.31758 1.000 19.78803 ? 14  GLU A N   1 
ATOM   100  C  CA  . GLU A 1 14  ? -15.15875 8.48006   -11.42036 1.000 19.49484 ? 14  GLU A CA  1 
ATOM   101  C  C   . GLU A 1 14  ? -16.43413 9.14251   -10.90345 1.000 21.57076 ? 14  GLU A C   1 
ATOM   102  O  O   . GLU A 1 14  ? -17.47356 8.48673   -10.76884 1.000 20.22352 ? 14  GLU A O   1 
ATOM   103  C  CB  . GLU A 1 14  ? -14.28494 8.06482   -10.23415 1.000 20.59637 ? 14  GLU A CB  1 
ATOM   104  C  CG  . GLU A 1 14  ? -13.11031 7.16196   -10.59076 1.000 17.59434 ? 14  GLU A CG  1 
ATOM   105  C  CD  . GLU A 1 14  ? -12.13080 7.01480   -9.42403  1.000 22.09251 ? 14  GLU A CD  1 
ATOM   106  O  OE1 . GLU A 1 14  ? -12.57303 6.62121   -8.32727  1.000 24.31714 ? 14  GLU A OE1 1 
ATOM   107  O  OE2 . GLU A 1 14  ? -10.92980 7.30077   -9.60788  1.000 18.94747 ? 14  GLU A OE2 1 
ATOM   108  N  N   . GLY A 1 15  ? -16.36809 10.43073  -10.57898 1.000 19.23269 ? 15  GLY A N   1 
ATOM   109  C  CA  . GLY A 1 15  ? -17.53747 11.10907  -10.06091 1.000 21.90497 ? 15  GLY A CA  1 
ATOM   110  C  C   . GLY A 1 15  ? -18.63489 11.35758  -11.07632 1.000 24.35091 ? 15  GLY A C   1 
ATOM   111  O  O   . GLY A 1 15  ? -19.67203 11.91707  -10.70868 1.000 24.16173 ? 15  GLY A O   1 
ATOM   112  N  N   . CYS A 1 16  ? -18.42814 10.97406  -12.34276 1.000 23.34986 ? 16  CYS A N   1 
ATOM   113  C  CA  . CYS A 1 16  ? -19.40640 11.16081  -13.40300 1.000 22.06674 ? 16  CYS A CA  1 
ATOM   114  C  C   . CYS A 1 16  ? -20.04013 9.86280   -13.87996 1.000 23.27563 ? 16  CYS A C   1 
ATOM   115  O  O   . CYS A 1 16  ? -20.95927 9.91405   -14.69831 1.000 22.41114 ? 16  CYS A O   1 
ATOM   116  C  CB  . CYS A 1 16  ? -18.76600 11.86610  -14.60226 1.000 21.90801 ? 16  CYS A CB  1 
ATOM   117  S  SG  . CYS A 1 16  ? -18.06845 13.46596  -14.25942 1.000 24.46650 ? 16  CYS A SG  1 
ATOM   118  N  N   . MET A 1 17  ? -19.58288 8.70458   -13.40658 1.000 19.81887 ? 17  MET A N   1 
ATOM   119  C  CA  . MET A 1 17  ? -20.03586 7.45185   -13.98979 1.000 16.50469 ? 17  MET A CA  1 
ATOM   120  C  C   . MET A 1 17  ? -21.35180 7.00372   -13.35717 1.000 19.74616 ? 17  MET A C   1 
ATOM   121  O  O   . MET A 1 17  ? -21.50656 7.01388   -12.13281 1.000 20.80194 ? 17  MET A O   1 
ATOM   122  C  CB  . MET A 1 17  ? -18.96114 6.37681   -13.84443 1.000 19.46126 ? 17  MET A CB  1 
ATOM   123  C  CG  . MET A 1 17  ? -17.64702 6.71265   -14.57467 1.000 18.97792 ? 17  MET A CG  1 
ATOM   124  S  SD  . MET A 1 17  ? -17.79312 7.23934   -16.31238 1.000 21.08292 ? 17  MET A SD  1 
ATOM   125  C  CE  . MET A 1 17  ? -18.72989 5.88165   -17.04516 1.000 18.09572 ? 17  MET A CE  1 
ATOM   126  N  N   . VAL A 1 18  ? -22.30903 6.63002   -14.20229 1.000 20.11764 ? 18  VAL A N   1 
ATOM   127  C  CA  . VAL A 1 18  ? -23.61623 6.16047   -13.76690 1.000 20.90775 ? 18  VAL A CA  1 
ATOM   128  C  C   . VAL A 1 18  ? -23.98253 4.92807   -14.57610 1.000 22.10655 ? 18  VAL A C   1 
ATOM   129  O  O   . VAL A 1 18  ? -23.35806 4.60436   -15.59190 1.000 20.66779 ? 18  VAL A O   1 
ATOM   130  C  CB  . VAL A 1 18  ? -24.72195 7.23170   -13.91408 1.000 23.52999 ? 18  VAL A CB  1 
ATOM   131  C  CG1 . VAL A 1 18  ? -24.38574 8.46402   -13.07920 1.000 19.86223 ? 18  VAL A CG1 1 
ATOM   132  C  CG2 . VAL A 1 18  ? -24.92843 7.59374   -15.38720 1.000 18.32368 ? 18  VAL A CG2 1 
ATOM   133  N  N   . GLN A 1 19  ? -25.01865 4.24671   -14.10331 1.000 19.48427 ? 19  GLN A N   1 
ATOM   134  C  CA  . GLN A 1 19  ? -25.57361 3.07108   -14.75524 1.000 22.83600 ? 19  GLN A CA  1 
ATOM   135  C  C   . GLN A 1 19  ? -26.83882 3.46788   -15.50761 1.000 27.25947 ? 19  GLN A C   1 
ATOM   136  O  O   . GLN A 1 19  ? -27.68559 4.17451   -14.95598 1.000 25.90285 ? 19  GLN A O   1 
ATOM   137  C  CB  . GLN A 1 19  ? -25.89381 2.01102   -13.70355 1.000 26.44315 ? 19  GLN A CB  1 
ATOM   138  C  CG  . GLN A 1 19  ? -26.22732 0.67167   -14.24929 1.000 27.69940 ? 19  GLN A CG  1 
ATOM   139  C  CD  . GLN A 1 19  ? -26.46524 -0.32218  -13.14057 1.000 35.10768 ? 19  GLN A CD  1 
ATOM   140  O  OE1 . GLN A 1 19  ? -25.94637 -1.43538  -13.16681 1.000 34.74066 ? 19  GLN A OE1 1 
ATOM   141  N  NE2 . GLN A 1 19  ? -27.25231 0.07897   -12.14944 1.000 40.39988 ? 19  GLN A NE2 1 
ATOM   142  N  N   . VAL A 1 20  ? -26.97120 3.02074   -16.75719 1.000 23.37810 ? 20  VAL A N   1 
ATOM   143  C  CA  . VAL A 1 20  ? -28.15847 3.29697   -17.55748 1.000 23.52154 ? 20  VAL A CA  1 
ATOM   144  C  C   . VAL A 1 20  ? -28.77691 1.97850   -17.98941 1.000 27.70876 ? 20  VAL A C   1 
ATOM   145  O  O   . VAL A 1 20  ? -28.09901 1.13306   -18.58569 1.000 25.67770 ? 20  VAL A O   1 
ATOM   146  C  CB  . VAL A 1 20  ? -27.84322 4.17200   -18.78130 1.000 20.56317 ? 20  VAL A CB  1 
ATOM   147  C  CG1 . VAL A 1 20  ? -29.11446 4.38728   -19.59728 1.000 19.84154 ? 20  VAL A CG1 1 
ATOM   148  C  CG2 . VAL A 1 20  ? -27.25728 5.49497   -18.35001 1.000 19.81910 ? 20  VAL A CG2 1 
ATOM   149  N  N   . THR A 1 21  ? -30.06763 1.81060   -17.70556 1.000 25.62169 ? 21  THR A N   1 
ATOM   150  C  CA  . THR A 1 21  ? -30.77993 0.58645   -18.03713 1.000 24.82935 ? 21  THR A CA  1 
ATOM   151  C  C   . THR A 1 21  ? -31.96951 0.90938   -18.92932 1.000 29.19077 ? 21  THR A C   1 
ATOM   152  O  O   . THR A 1 21  ? -32.70170 1.87131   -18.68542 1.000 23.95154 ? 21  THR A O   1 
ATOM   153  C  CB  . THR A 1 21  ? -31.24837 -0.14936  -16.77444 1.000 31.11243 ? 21  THR A CB  1 
ATOM   154  O  OG1 . THR A 1 21  ? -30.11867 -0.73731  -16.11708 1.000 30.82336 ? 21  THR A OG1 1 
ATOM   155  C  CG2 . THR A 1 21  ? -32.25147 -1.24804  -17.12088 1.000 33.94398 ? 21  THR A CG2 1 
ATOM   156  N  N   . CYS A 1 22  ? -32.13259 0.11539   -19.98383 1.000 29.93299 ? 22  CYS A N   1 
ATOM   157  C  CA  . CYS A 1 22  ? -33.30430 0.18773   -20.84393 1.000 31.45999 ? 22  CYS A CA  1 
ATOM   158  C  C   . CYS A 1 22  ? -33.67464 -1.23912  -21.20499 1.000 34.04466 ? 22  CYS A C   1 
ATOM   159  O  O   . CYS A 1 22  ? -32.84951 -1.96859  -21.76463 1.000 30.18536 ? 22  CYS A O   1 
ATOM   160  C  CB  . CYS A 1 22  ? -33.02650 1.02518   -22.09261 1.000 26.48589 ? 22  CYS A CB  1 
ATOM   161  S  SG  . CYS A 1 22  ? -34.49571 1.36619   -23.08129 1.000 40.86403 ? 22  CYS A SG  1 
ATOM   162  N  N   . GLY A 1 23  ? -34.89791 -1.64242  -20.87292 1.000 32.44757 ? 23  GLY A N   1 
ATOM   163  C  CA  . GLY A 1 23  ? -35.24901 -3.04168  -21.04779 1.000 35.38301 ? 23  GLY A CA  1 
ATOM   164  C  C   . GLY A 1 23  ? -34.34163 -3.91488  -20.20107 1.000 30.76584 ? 23  GLY A C   1 
ATOM   165  O  O   . GLY A 1 23  ? -34.21022 -3.72154  -18.98722 1.000 35.42573 ? 23  GLY A O   1 
ATOM   166  N  N   . THR A 1 24  ? -33.69352 -4.88637  -20.84390 1.000 33.03249 ? 24  THR A N   1 
ATOM   167  C  CA  . THR A 1 24  ? -32.73603 -5.75717  -20.17629 1.000 35.12834 ? 24  THR A CA  1 
ATOM   168  C  C   . THR A 1 24  ? -31.28747 -5.37441  -20.46234 1.000 37.30848 ? 24  THR A C   1 
ATOM   169  O  O   . THR A 1 24  ? -30.37390 -6.06914  -19.99780 1.000 33.67888 ? 24  THR A O   1 
ATOM   170  C  CB  . THR A 1 24  ? -32.97480 -7.21386  -20.58548 1.000 34.92707 ? 24  THR A CB  1 
ATOM   171  O  OG1 . THR A 1 24  ? -32.60338 -7.39333  -21.95404 1.000 36.02263 ? 24  THR A OG1 1 
ATOM   172  C  CG2 . THR A 1 24  ? -34.44369 -7.57106  -20.42633 1.000 40.26925 ? 24  THR A CG2 1 
ATOM   173  N  N   . THR A 1 25  ? -31.05769 -4.29476  -21.21286 1.000 33.70461 ? 25  THR A N   1 
ATOM   174  C  CA  . THR A 1 25  ? -29.71108 -3.83745  -21.54302 1.000 29.92951 ? 25  THR A CA  1 
ATOM   175  C  C   . THR A 1 25  ? -29.24171 -2.82209  -20.51181 1.000 27.97569 ? 25  THR A C   1 
ATOM   176  O  O   . THR A 1 25  ? -29.93903 -1.84218  -20.23925 1.000 26.50166 ? 25  THR A O   1 
ATOM   177  C  CB  . THR A 1 25  ? -29.68091 -3.21554  -22.93935 1.000 26.30200 ? 25  THR A CB  1 
ATOM   178  O  OG1 . THR A 1 25  ? -30.00650 -4.21645  -23.90376 1.000 31.91986 ? 25  THR A OG1 1 
ATOM   179  C  CG2 . THR A 1 25  ? -28.30681 -2.64988  -23.25167 1.000 30.58048 ? 25  THR A CG2 1 
ATOM   180  N  N   . THR A 1 26  ? -28.05706 -3.05172  -19.94820 1.000 28.04040 ? 26  THR A N   1 
ATOM   181  C  CA  . THR A 1 26  ? -27.48567 -2.16064  -18.94555 1.000 25.70216 ? 26  THR A CA  1 
ATOM   182  C  C   . THR A 1 26  ? -26.04845 -1.83294  -19.32758 1.000 27.35502 ? 26  THR A C   1 
ATOM   183  O  O   . THR A 1 26  ? -25.24452 -2.73976  -19.55777 1.000 30.07236 ? 26  THR A O   1 
ATOM   184  C  CB  . THR A 1 26  ? -27.53675 -2.78893  -17.54113 1.000 28.43808 ? 26  THR A CB  1 
ATOM   185  O  OG1 . THR A 1 26  ? -28.89760 -2.86149  -17.09472 1.000 30.04299 ? 26  THR A OG1 1 
ATOM   186  C  CG2 . THR A 1 26  ? -26.73839 -1.96434  -16.54859 1.000 25.08644 ? 26  THR A CG2 1 
ATOM   187  N  N   . LEU A 1 27  ? -25.72751 -0.54476  -19.39497 1.000 20.53548 ? 27  LEU A N   1 
ATOM   188  C  CA  . LEU A 1 27  ? -24.36651 -0.11170  -19.67371 1.000 22.00556 ? 27  LEU A CA  1 
ATOM   189  C  C   . LEU A 1 27  ? -24.09691 1.15991   -18.88115 1.000 19.98899 ? 27  LEU A C   1 
ATOM   190  O  O   . LEU A 1 27  ? -24.88513 1.56155   -18.01615 1.000 22.79790 ? 27  LEU A O   1 
ATOM   191  C  CB  . LEU A 1 27  ? -24.15123 0.06046   -21.18311 1.000 24.06099 ? 27  LEU A CB  1 
ATOM   192  C  CG  . LEU A 1 27  ? -25.28319 0.66127   -22.00051 1.000 22.82932 ? 27  LEU A CG  1 
ATOM   193  C  CD1 . LEU A 1 27  ? -25.40776 2.15106   -21.71075 1.000 24.63331 ? 27  LEU A CD1 1 
ATOM   194  C  CD2 . LEU A 1 27  ? -25.06789 0.40931   -23.48297 1.000 23.71782 ? 27  LEU A CD2 1 
ATOM   195  N  N   . ASN A 1 28  ? -22.96874 1.79180   -19.17519 1.000 17.74589 ? 28  ASN A N   1 
ATOM   196  C  CA  . ASN A 1 28  ? -22.52078 2.95380   -18.43156 1.000 17.74939 ? 28  ASN A CA  1 
ATOM   197  C  C   . ASN A 1 28  ? -22.98002 4.23053   -19.11688 1.000 18.29182 ? 28  ASN A C   1 
ATOM   198  O  O   . ASN A 1 28  ? -23.14393 4.28167   -20.33653 1.000 19.57239 ? 28  ASN A O   1 
ATOM   199  C  CB  . ASN A 1 28  ? -20.99080 2.95849   -18.29405 1.000 15.76129 ? 28  ASN A CB  1 
ATOM   200  C  CG  . ASN A 1 28  ? -20.45904 1.67387   -17.68477 1.000 18.65407 ? 28  ASN A CG  1 
ATOM   201  O  OD1 . ASN A 1 28  ? -20.52495 1.46977   -16.47006 1.000 17.42701 ? 28  ASN A OD1 1 
ATOM   202  N  ND2 . ASN A 1 28  ? -19.95052 0.78599   -18.53253 1.000 17.31202 ? 28  ASN A ND2 1 
ATOM   203  N  N   . GLY A 1 29  ? -23.19481 5.26684   -18.31035 1.000 19.02913 ? 29  GLY A N   1 
ATOM   204  C  CA  . GLY A 1 29  ? -23.42781 6.58935   -18.83215 1.000 17.56123 ? 29  GLY A CA  1 
ATOM   205  C  C   . GLY A 1 29  ? -22.49752 7.57533   -18.15561 1.000 17.88874 ? 29  GLY A C   1 
ATOM   206  O  O   . GLY A 1 29  ? -21.93949 7.30860   -17.09585 1.000 19.05392 ? 29  GLY A O   1 
ATOM   207  N  N   . LEU A 1 30  ? -22.34038 8.72413   -18.79569 1.000 19.25010 ? 30  LEU A N   1 
ATOM   208  C  CA  . LEU A 1 30  ? -21.49022 9.79877   -18.30705 1.000 17.44961 ? 30  LEU A CA  1 
ATOM   209  C  C   . LEU A 1 30  ? -22.38673 10.96402  -17.90118 1.000 22.20929 ? 30  LEU A C   1 
ATOM   210  O  O   . LEU A 1 30  ? -23.07606 11.54185  -18.74920 1.000 21.39166 ? 30  LEU A O   1 
ATOM   211  C  CB  . LEU A 1 30  ? -20.48587 10.22277  -19.37973 1.000 18.48000 ? 30  LEU A CB  1 
ATOM   212  C  CG  . LEU A 1 30  ? -19.48909 11.31529  -18.99079 1.000 16.36551 ? 30  LEU A CG  1 
ATOM   213  C  CD1 . LEU A 1 30  ? -18.45166 10.75557  -18.02000 1.000 18.86639 ? 30  LEU A CD1 1 
ATOM   214  C  CD2 . LEU A 1 30  ? -18.82864 11.88494  -20.22435 1.000 21.40680 ? 30  LEU A CD2 1 
ATOM   215  N  N   . TRP A 1 31  ? -22.36768 11.30678  -16.60714 1.000 22.71430 ? 31  TRP A N   1 
ATOM   216  C  CA  . TRP A 1 31  ? -23.28955 12.27196  -16.01453 1.000 22.13152 ? 31  TRP A CA  1 
ATOM   217  C  C   . TRP A 1 31  ? -22.57342 13.60477  -15.84814 1.000 25.16723 ? 31  TRP A C   1 
ATOM   218  O  O   . TRP A 1 31  ? -21.72058 13.75248  -14.96587 1.000 24.82511 ? 31  TRP A O   1 
ATOM   219  C  CB  . TRP A 1 31  ? -23.78894 11.75134  -14.67052 1.000 27.24633 ? 31  TRP A CB  1 
ATOM   220  C  CG  . TRP A 1 31  ? -24.80126 12.60276  -13.96050 1.000 26.19677 ? 31  TRP A CG  1 
ATOM   221  C  CD1 . TRP A 1 31  ? -25.61075 13.56489  -14.50455 1.000 28.63604 ? 31  TRP A CD1 1 
ATOM   222  C  CD2 . TRP A 1 31  ? -25.12084 12.55079  -12.56804 1.000 24.33545 ? 31  TRP A CD2 1 
ATOM   223  N  NE1 . TRP A 1 31  ? -26.41077 14.11583  -13.53072 1.000 28.21670 ? 31  TRP A NE1 1 
ATOM   224  C  CE2 . TRP A 1 31  ? -26.13120 13.50703  -12.33333 1.000 30.30819 ? 31  TRP A CE2 1 
ATOM   225  C  CE3 . TRP A 1 31  ? -24.65188 11.78454  -11.49416 1.000 28.15566 ? 31  TRP A CE3 1 
ATOM   226  C  CZ2 . TRP A 1 31  ? -26.67744 13.71841  -11.06752 1.000 29.36351 ? 31  TRP A CZ2 1 
ATOM   227  C  CZ3 . TRP A 1 31  ? -25.19252 11.99649  -10.23580 1.000 27.28756 ? 31  TRP A CZ3 1 
ATOM   228  C  CH2 . TRP A 1 31  ? -26.19601 12.95506  -10.03412 1.000 30.19032 ? 31  TRP A CH2 1 
ATOM   229  N  N   . LEU A 1 32  ? -22.92008 14.57336  -16.69204 1.000 24.01076 ? 32  LEU A N   1 
ATOM   230  C  CA  . LEU A 1 32  ? -22.33355 15.90614  -16.63654 1.000 24.70368 ? 32  LEU A CA  1 
ATOM   231  C  C   . LEU A 1 32  ? -23.45978 16.92510  -16.56924 1.000 27.99683 ? 32  LEU A C   1 
ATOM   232  O  O   . LEU A 1 32  ? -24.34789 16.91845  -17.42722 1.000 28.64916 ? 32  LEU A O   1 
ATOM   233  C  CB  . LEU A 1 32  ? -21.44748 16.17267  -17.85119 1.000 23.17858 ? 32  LEU A CB  1 
ATOM   234  C  CG  . LEU A 1 32  ? -20.30519 15.19004  -18.10070 1.000 23.27079 ? 32  LEU A CG  1 
ATOM   235  C  CD1 . LEU A 1 32  ? -19.78138 15.38841  -19.51328 1.000 21.64915 ? 32  LEU A CD1 1 
ATOM   236  C  CD2 . LEU A 1 32  ? -19.18804 15.38607  -17.06718 1.000 19.29393 ? 32  LEU A CD2 1 
ATOM   237  N  N   . ASP A 1 33  ? -23.41712 17.80109  -15.55995 1.000 30.15460 ? 33  ASP A N   1 
ATOM   238  C  CA  . ASP A 1 33  ? -24.51949 18.73702  -15.26709 1.000 27.95290 ? 33  ASP A CA  1 
ATOM   239  C  C   . ASP A 1 33  ? -25.79368 17.89645  -15.18063 1.000 26.16710 ? 33  ASP A C   1 
ATOM   240  O  O   . ASP A 1 33  ? -25.80549 16.88492  -14.46549 1.000 26.41808 ? 33  ASP A O   1 
ATOM   241  C  CB  . ASP A 1 33  ? -24.54809 19.86017  -16.29748 1.000 27.78575 ? 33  ASP A CB  1 
ATOM   242  C  CG  . ASP A 1 33  ? -23.19881 20.53362  -16.47737 1.000 34.18086 ? 33  ASP A CG  1 
ATOM   243  O  OD1 . ASP A 1 33  ? -22.55834 20.87931  -15.46167 1.000 40.77542 ? 33  ASP A OD1 1 
ATOM   244  O  OD2 . ASP A 1 33  ? -22.77350 20.72025  -17.64037 1.000 38.26364 ? 33  ASP A OD2 1 
ATOM   245  N  N   . ASP A 1 34  ? -26.85541 18.23411  -15.91446 1.000 26.75001 ? 34  ASP A N   1 
ATOM   246  C  CA  . ASP A 1 34  ? -28.11297 17.49829  -15.86933 1.000 25.03184 ? 34  ASP A CA  1 
ATOM   247  C  C   . ASP A 1 34  ? -28.31685 16.58478  -17.08383 1.000 31.28382 ? 34  ASP A C   1 
ATOM   248  O  O   . ASP A 1 34  ? -29.45977 16.25417  -17.42216 1.000 28.79409 ? 34  ASP A O   1 
ATOM   249  C  CB  . ASP A 1 34  ? -29.28362 18.47543  -15.74083 1.000 35.48300 ? 34  ASP A CB  1 
ATOM   250  C  CG  . ASP A 1 34  ? -29.43646 19.38262  -16.96042 1.000 37.70234 ? 34  ASP A CG  1 
ATOM   251  O  OD1 . ASP A 1 34  ? -28.44329 19.58693  -17.69303 1.000 33.54358 ? 34  ASP A OD1 1 
ATOM   252  O  OD2 . ASP A 1 34  ? -30.55546 19.89937  -17.17814 1.000 41.88779 ? 34  ASP A OD2 1 
ATOM   253  N  N   . VAL A 1 35  ? -27.23767 16.15713  -17.74080 1.000 26.11609 ? 35  VAL A N   1 
ATOM   254  C  CA  . VAL A 1 35  ? -27.31377 15.30871  -18.92814 1.000 22.57452 ? 35  VAL A CA  1 
ATOM   255  C  C   . VAL A 1 35  ? -26.52397 14.03125  -18.67504 1.000 23.60016 ? 35  VAL A C   1 
ATOM   256  O  O   . VAL A 1 35  ? -25.38199 14.08817  -18.20059 1.000 23.19350 ? 35  VAL A O   1 
ATOM   257  C  CB  . VAL A 1 35  ? -26.77367 16.03220  -20.17593 1.000 24.27237 ? 35  VAL A CB  1 
ATOM   258  C  CG1 . VAL A 1 35  ? -26.86850 15.12584  -21.39383 1.000 25.11626 ? 35  VAL A CG1 1 
ATOM   259  C  CG2 . VAL A 1 35  ? -27.52982 17.33640  -20.41079 1.000 27.15502 ? 35  VAL A CG2 1 
ATOM   260  N  N   . VAL A 1 36  ? -27.12082 12.88598  -19.00328 1.000 22.84075 ? 36  VAL A N   1 
ATOM   261  C  CA  . VAL A 1 36  ? -26.42135 11.60393  -19.00565 1.000 21.83646 ? 36  VAL A CA  1 
ATOM   262  C  C   . VAL A 1 36  ? -26.20546 11.18492  -20.45947 1.000 23.07642 ? 36  VAL A C   1 
ATOM   263  O  O   . VAL A 1 36  ? -27.16702 11.07011  -21.23610 1.000 24.51858 ? 36  VAL A O   1 
ATOM   264  C  CB  . VAL A 1 36  ? -27.18409 10.53630  -18.20657 1.000 21.17205 ? 36  VAL A CB  1 
ATOM   265  C  CG1 . VAL A 1 36  ? -26.52222 9.18917   -18.34010 1.000 21.49106 ? 36  VAL A CG1 1 
ATOM   266  C  CG2 . VAL A 1 36  ? -27.24811 10.93435  -16.73074 1.000 19.85015 ? 36  VAL A CG2 1 
ATOM   267  N  N   . TYR A 1 37  ? -24.93829 10.98239  -20.82888 1.000 20.93176 ? 37  TYR A N   1 
ATOM   268  C  CA  . TYR A 1 37  ? -24.53860 10.54251  -22.16420 1.000 20.86618 ? 37  TYR A CA  1 
ATOM   269  C  C   . TYR A 1 37  ? -24.25768 9.04813   -22.13894 1.000 18.74582 ? 37  TYR A C   1 
ATOM   270  O  O   . TYR A 1 37  ? -23.55496 8.57295   -21.24545 1.000 22.30811 ? 37  TYR A O   1 
ATOM   271  C  CB  . TYR A 1 37  ? -23.28175 11.27792  -22.63600 1.000 20.76351 ? 37  TYR A CB  1 
ATOM   272  C  CG  . TYR A 1 37  ? -23.38019 12.78553  -22.64937 1.000 26.38380 ? 37  TYR A CG  1 
ATOM   273  C  CD1 . TYR A 1 37  ? -23.30152 13.51873  -21.46476 1.000 25.36068 ? 37  TYR A CD1 1 
ATOM   274  C  CD2 . TYR A 1 37  ? -23.52923 13.48189  -23.84749 1.000 23.64244 ? 37  TYR A CD2 1 
ATOM   275  C  CE1 . TYR A 1 37  ? -23.38749 14.89966  -21.46652 1.000 24.80077 ? 37  TYR A CE1 1 
ATOM   276  C  CE2 . TYR A 1 37  ? -23.61229 14.86750  -23.85989 1.000 26.32791 ? 37  TYR A CE2 1 
ATOM   277  C  CZ  . TYR A 1 37  ? -23.54691 15.56932  -22.66327 1.000 28.73266 ? 37  TYR A CZ  1 
ATOM   278  O  OH  . TYR A 1 37  ? -23.62911 16.94387  -22.66079 1.000 28.68481 ? 37  TYR A OH  1 
ATOM   279  N  N   . CYS A 1 38  ? -24.77836 8.31312   -23.12059 1.000 22.83989 ? 38  CYS A N   1 
ATOM   280  C  CA  . CYS A 1 38  ? -24.50454 6.88646   -23.21971 1.000 20.94265 ? 38  CYS A CA  1 
ATOM   281  C  C   . CYS A 1 38  ? -24.66986 6.43375   -24.65769 1.000 23.51192 ? 38  CYS A C   1 
ATOM   282  O  O   . CYS A 1 38  ? -25.26274 7.15456   -25.48329 1.000 20.29018 ? 38  CYS A O   1 
ATOM   283  C  CB  . CYS A 1 38  ? -25.41396 6.08232   -22.28066 1.000 18.73188 ? 38  CYS A CB  1 
ATOM   284  S  SG  . CYS A 1 38  ? -27.13845 5.98143   -22.81933 1.000 23.33733 ? 38  CYS A SG  1 
ATOM   285  N  N   . PRO A 1 39  ? -24.14317 5.26091   -25.03013 1.000 21.62456 ? 39  PRO A N   1 
ATOM   286  C  CA  . PRO A 1 39  ? -24.32085 4.77366   -26.39790 1.000 19.61886 ? 39  PRO A CA  1 
ATOM   287  C  C   . PRO A 1 39  ? -25.80040 4.55909   -26.69241 1.000 22.94355 ? 39  PRO A C   1 
ATOM   288  O  O   . PRO A 1 39  ? -26.54452 4.04091   -25.85821 1.000 20.05831 ? 39  PRO A O   1 
ATOM   289  C  CB  . PRO A 1 39  ? -23.53864 3.45471   -26.42042 1.000 17.38057 ? 39  PRO A CB  1 
ATOM   290  C  CG  . PRO A 1 39  ? -22.52976 3.59030   -25.30668 1.000 21.42014 ? 39  PRO A CG  1 
ATOM   291  C  CD  . PRO A 1 39  ? -23.27868 4.35594   -24.23521 1.000 18.33835 ? 39  PRO A CD  1 
ATOM   292  N  N   . ARG A 1 40  ? -26.22759 4.95908   -27.89357 1.000 18.65317 ? 40  ARG A N   1 
ATOM   293  C  CA  . ARG A 1 40  ? -27.64289 4.83077   -28.22582 1.000 20.96097 ? 40  ARG A CA  1 
ATOM   294  C  C   . ARG A 1 40  ? -28.07901 3.37643   -28.39069 1.000 23.45736 ? 40  ARG A C   1 
ATOM   295  O  O   . ARG A 1 40  ? -29.27507 3.08900   -28.28089 1.000 25.66718 ? 40  ARG A O   1 
ATOM   296  C  CB  . ARG A 1 40  ? -27.96668 5.63619   -29.48496 1.000 19.73101 ? 40  ARG A CB  1 
ATOM   297  C  CG  . ARG A 1 40  ? -27.42830 5.06063   -30.76977 1.000 22.54050 ? 40  ARG A CG  1 
ATOM   298  C  CD  . ARG A 1 40  ? -27.79094 5.92079   -31.96903 1.000 22.16520 ? 40  ARG A CD  1 
ATOM   299  N  NE  . ARG A 1 40  ? -27.16144 5.40179   -33.17808 1.000 24.72675 ? 40  ARG A NE  1 
ATOM   300  C  CZ  . ARG A 1 40  ? -27.46052 5.78019   -34.41209 1.000 22.92148 ? 40  ARG A CZ  1 
ATOM   301  N  NH1 . ARG A 1 40  ? -28.37531 6.70960   -34.64957 1.000 22.45719 ? 40  ARG A NH1 1 
ATOM   302  N  NH2 . ARG A 1 40  ? -26.84253 5.19447   -35.43530 1.000 22.91795 ? 40  ARG A NH2 1 
ATOM   303  N  N   . HIS A 1 41  ? -27.14990 2.44115   -28.61010 1.000 20.62452 ? 41  HIS A N   1 
ATOM   304  C  CA  . HIS A 1 41  ? -27.58346 1.04677   -28.69894 1.000 21.63207 ? 41  HIS A CA  1 
ATOM   305  C  C   . HIS A 1 41  ? -28.07562 0.48319   -27.36398 1.000 23.06327 ? 41  HIS A C   1 
ATOM   306  O  O   . HIS A 1 41  ? -28.45179 -0.69069  -27.30190 1.000 24.48133 ? 41  HIS A O   1 
ATOM   307  C  CB  . HIS A 1 41  ? -26.47848 0.16627   -29.31832 1.000 23.87457 ? 41  HIS A CB  1 
ATOM   308  C  CG  . HIS A 1 41  ? -25.29247 -0.09585  -28.44515 1.000 23.73821 ? 41  HIS A CG  1 
ATOM   309  N  ND1 . HIS A 1 41  ? -25.34948 -0.90378  -27.33119 1.000 25.93701 ? 41  HIS A ND1 1 
ATOM   310  C  CD2 . HIS A 1 41  ? -23.99503 0.27925   -28.57201 1.000 24.59744 ? 41  HIS A CD2 1 
ATOM   311  C  CE1 . HIS A 1 41  ? -24.14593 -0.98259  -26.78583 1.000 25.11152 ? 41  HIS A CE1 1 
ATOM   312  N  NE2 . HIS A 1 41  ? -23.30387 -0.28312  -27.52496 1.000 20.59311 ? 41  HIS A NE2 1 
ATOM   313  N  N   . VAL A 1 42  ? -28.12366 1.28985   -26.30481 1.000 21.39917 ? 42  VAL A N   1 
ATOM   314  C  CA  . VAL A 1 42  ? -28.81401 0.87445   -25.08376 1.000 22.92729 ? 42  VAL A CA  1 
ATOM   315  C  C   . VAL A 1 42  ? -30.28421 0.54877   -25.35755 1.000 27.50334 ? 42  VAL A C   1 
ATOM   316  O  O   . VAL A 1 42  ? -30.87322 -0.29692  -24.67234 1.000 29.06708 ? 42  VAL A O   1 
ATOM   317  C  CB  . VAL A 1 42  ? -28.67310 1.96516   -24.00395 1.000 24.01851 ? 42  VAL A CB  1 
ATOM   318  C  CG1 . VAL A 1 42  ? -29.45407 3.21889   -24.38651 1.000 22.83516 ? 42  VAL A CG1 1 
ATOM   319  C  CG2 . VAL A 1 42  ? -29.07932 1.45168   -22.62834 1.000 24.83104 ? 42  VAL A CG2 1 
ATOM   320  N  N   . ILE A 1 43  ? -30.88667 1.16522   -26.38375 1.000 26.02453 ? 43  ILE A N   1 
ATOM   321  C  CA  . ILE A 1 43  ? -32.32203 0.99942   -26.63492 1.000 30.10320 ? 43  ILE A CA  1 
ATOM   322  C  C   . ILE A 1 43  ? -32.60348 -0.17187  -27.56843 1.000 30.65786 ? 43  ILE A C   1 
ATOM   323  O  O   . ILE A 1 43  ? -33.73832 -0.35814  -28.01302 1.000 31.08915 ? 43  ILE A O   1 
ATOM   324  C  CB  . ILE A 1 43  ? -32.95268 2.28218   -27.20764 1.000 25.80367 ? 43  ILE A CB  1 
ATOM   325  C  CG1 . ILE A 1 43  ? -32.44288 2.54412   -28.63197 1.000 26.05667 ? 43  ILE A CG1 1 
ATOM   326  C  CG2 . ILE A 1 43  ? -32.67563 3.45763   -26.30249 1.000 24.14710 ? 43  ILE A CG2 1 
ATOM   327  C  CD1 . ILE A 1 43  ? -33.02820 3.78437   -29.28983 1.000 22.61935 ? 43  ILE A CD1 1 
ATOM   328  N  N   . CYS A 1 44  ? -31.59826 -0.98554  -27.85670 1.000 31.75748 ? 44  CYS A N   1 
ATOM   329  C  CA  . CYS A 1 44  ? -31.78112 -2.06379  -28.81462 1.000 38.65442 ? 44  CYS A CA  1 
ATOM   330  C  C   . CYS A 1 44  ? -32.14375 -3.37751  -28.13491 1.000 40.41352 ? 44  CYS A C   1 
ATOM   331  O  O   . CYS A 1 44  ? -31.74602 -3.64694  -26.99969 1.000 40.84595 ? 44  CYS A O   1 
ATOM   332  C  CB  . CYS A 1 44  ? -30.51850 -2.25940  -29.64524 1.000 32.77876 ? 44  CYS A CB  1 
ATOM   333  S  SG  . CYS A 1 44  ? -30.20056 -0.95896  -30.81416 1.000 35.67516 ? 44  CYS A SG  1 
ATOM   334  N  N   . THR A 1 45  ? -32.90460 -4.19613  -28.85842 1.000 50.40144 ? 45  THR A N   1 
ATOM   335  C  CA  . THR A 1 45  ? -33.16170 -5.58657  -28.51400 1.000 54.47342 ? 45  THR A CA  1 
ATOM   336  C  C   . THR A 1 45  ? -32.22463 -6.48017  -29.32299 1.000 56.29030 ? 45  THR A C   1 
ATOM   337  O  O   . THR A 1 45  ? -31.50709 -6.02401  -30.21909 1.000 56.45492 ? 45  THR A O   1 
ATOM   338  C  CB  . THR A 1 45  ? -34.63035 -5.95062  -28.78609 1.000 55.00784 ? 45  THR A CB  1 
ATOM   339  O  OG1 . THR A 1 45  ? -35.47797 -4.86049  -28.40187 1.000 55.46997 ? 45  THR A OG1 1 
ATOM   340  C  CG2 . THR A 1 45  ? -35.05116 -7.19251  -28.00363 1.000 63.91251 ? 45  THR A CG2 1 
ATOM   341  N  N   . SER A 1 46  ? -32.21922 -7.77013  -28.98280 1.000 58.98463 ? 46  SER A N   1 
ATOM   342  C  CA  . SER A 1 46  ? -31.47258 -8.72883  -29.78783 1.000 63.75656 ? 46  SER A CA  1 
ATOM   343  C  C   . SER A 1 46  ? -31.97210 -8.75164  -31.22736 1.000 59.25629 ? 46  SER A C   1 
ATOM   344  O  O   . SER A 1 46  ? -31.18550 -8.97865  -32.15281 1.000 58.58968 ? 46  SER A O   1 
ATOM   345  C  CB  . SER A 1 46  ? -31.56973 -10.12140 -29.16729 1.000 65.84219 ? 46  SER A CB  1 
ATOM   346  O  OG  . SER A 1 46  ? -32.91128 -10.58119 -29.16227 1.000 67.82209 ? 46  SER A OG  1 
ATOM   347  N  N   . GLU A 1 47  ? -33.26975 -8.50680  -31.43655 1.000 61.81786 ? 47  GLU A N   1 
ATOM   348  C  CA  . GLU A 1 47  ? -33.84828 -8.48443  -32.77671 1.000 60.47292 ? 47  GLU A CA  1 
ATOM   349  C  C   . GLU A 1 47  ? -33.47942 -7.23340  -33.56584 1.000 53.66155 ? 47  GLU A C   1 
ATOM   350  O  O   . GLU A 1 47  ? -33.78596 -7.16282  -34.76167 1.000 54.27980 ? 47  GLU A O   1 
ATOM   351  C  CB  . GLU A 1 47  ? -35.37356 -8.60156  -32.68926 1.000 58.58001 ? 47  GLU A CB  1 
ATOM   352  N  N   . ASP A 1 48  ? -32.83873 -6.25288  -32.93460 1.000 54.68880 ? 48  ASP A N   1 
ATOM   353  C  CA  . ASP A 1 48  ? -32.50342 -4.98650  -33.57156 1.000 49.08459 ? 48  ASP A CA  1 
ATOM   354  C  C   . ASP A 1 48  ? -31.03860 -4.88474  -33.96619 1.000 41.84351 ? 48  ASP A C   1 
ATOM   355  O  O   . ASP A 1 48  ? -30.61347 -3.82219  -34.41652 1.000 42.80298 ? 48  ASP A O   1 
ATOM   356  C  CB  . ASP A 1 48  ? -32.84859 -3.81708  -32.63802 1.000 42.60207 ? 48  ASP A CB  1 
ATOM   357  C  CG  . ASP A 1 48  ? -34.33489 -3.71856  -32.34355 1.000 50.59308 ? 48  ASP A CG  1 
ATOM   358  O  OD1 . ASP A 1 48  ? -35.11784 -3.50288  -33.29563 1.000 46.55164 ? 48  ASP A OD1 1 
ATOM   359  O  OD2 . ASP A 1 48  ? -34.71683 -3.86221  -31.15887 1.000 47.53962 ? 48  ASP A OD2 1 
ATOM   360  N  N   . MET A 1 49  ? -30.25889 -5.95533  -33.81264 1.000 43.26920 ? 49  MET A N   1 
ATOM   361  C  CA  . MET A 1 49  ? -28.80601 -5.82032  -33.87534 1.000 46.03452 ? 49  MET A CA  1 
ATOM   362  C  C   . MET A 1 49  ? -28.30105 -5.56987  -35.28839 1.000 40.30273 ? 49  MET A C   1 
ATOM   363  O  O   . MET A 1 49  ? -27.30821 -4.85468  -35.47320 1.000 36.75940 ? 49  MET A O   1 
ATOM   364  C  CB  . MET A 1 49  ? -28.13996 -7.06945  -33.30170 1.000 54.99035 ? 49  MET A CB  1 
ATOM   365  C  CG  . MET A 1 49  ? -28.11345 -7.12354  -31.78429 1.000 59.06467 ? 49  MET A CG  1 
ATOM   366  S  SD  . MET A 1 49  ? -27.12366 -5.78786  -31.08440 1.000 76.54708 ? 49  MET A SD  1 
ATOM   367  C  CE  . MET A 1 49  ? -28.40786 -4.65528  -30.58402 1.000 51.16646 ? 49  MET A CE  1 
ATOM   368  N  N   . LEU A 1 50  ? -28.95645 -6.14822  -36.28883 1.000 33.93178 ? 50  LEU A N   1 
ATOM   369  C  CA  . LEU A 1 50  ? -28.40464 -6.11568  -37.63302 1.000 32.49224 ? 50  LEU A CA  1 
ATOM   370  C  C   . LEU A 1 50  ? -28.74532 -4.82254  -38.36627 1.000 32.55142 ? 50  LEU A C   1 
ATOM   371  O  O   . LEU A 1 50  ? -27.88220 -4.25481  -39.04664 1.000 29.93032 ? 50  LEU A O   1 
ATOM   372  C  CB  . LEU A 1 50  ? -28.88226 -7.33832  -38.40957 1.000 33.83317 ? 50  LEU A CB  1 
ATOM   373  C  CG  . LEU A 1 50  ? -28.16292 -8.60293  -37.95214 1.000 34.36743 ? 50  LEU A CG  1 
ATOM   374  C  CD1 . LEU A 1 50  ? -28.70347 -9.82130  -38.64934 1.000 32.96574 ? 50  LEU A CD1 1 
ATOM   375  C  CD2 . LEU A 1 50  ? -26.65960 -8.47894  -38.20182 1.000 34.08194 ? 50  LEU A CD2 1 
ATOM   376  N  N   . ASN A 1 51  ? -29.98028 -4.33528  -38.23809 1.000 28.61734 ? 51  ASN A N   1 
ATOM   377  C  CA  . ASN A 1 51  ? -30.40550 -3.10103  -38.90132 1.000 29.12212 ? 51  ASN A CA  1 
ATOM   378  C  C   . ASN A 1 51  ? -31.29022 -2.28599  -37.96736 1.000 31.10871 ? 51  ASN A C   1 
ATOM   379  O  O   . ASN A 1 51  ? -32.45956 -2.02418  -38.26295 1.000 29.49623 ? 51  ASN A O   1 
ATOM   380  C  CB  . ASN A 1 51  ? -31.12113 -3.41280  -40.21599 1.000 27.75999 ? 51  ASN A CB  1 
ATOM   381  C  CG  . ASN A 1 51  ? -30.19981 -4.06707  -41.22745 1.000 29.87963 ? 51  ASN A CG  1 
ATOM   382  O  OD1 . ASN A 1 51  ? -29.38562 -3.39740  -41.86376 1.000 27.26471 ? 51  ASN A OD1 1 
ATOM   383  N  ND2 . ASN A 1 51  ? -30.30463 -5.38433  -41.36118 1.000 25.72386 ? 51  ASN A ND2 1 
ATOM   384  N  N   . PRO A 1 52  ? -30.74563 -1.83339  -36.83714 1.000 30.79385 ? 52  PRO A N   1 
ATOM   385  C  CA  . PRO A 1 52  ? -31.55034 -1.02308  -35.91868 1.000 28.56698 ? 52  PRO A CA  1 
ATOM   386  C  C   . PRO A 1 52  ? -31.95004 0.28586   -36.57361 1.000 29.06758 ? 52  PRO A C   1 
ATOM   387  O  O   . PRO A 1 52  ? -31.14290 0.95019   -37.22722 1.000 25.31010 ? 52  PRO A O   1 
ATOM   388  C  CB  . PRO A 1 52  ? -30.61200 -0.78640  -34.73085 1.000 27.66482 ? 52  PRO A CB  1 
ATOM   389  C  CG  . PRO A 1 52  ? -29.25085 -0.82982  -35.34878 1.000 30.84970 ? 52  PRO A CG  1 
ATOM   390  C  CD  . PRO A 1 52  ? -29.32762 -1.86459  -36.43949 1.000 31.51561 ? 52  PRO A CD  1 
ATOM   391  N  N   . ASN A 1 53  ? -33.21517 0.64615   -36.39843 1.000 25.50544 ? 53  ASN A N   1 
ATOM   392  C  CA  . ASN A 1 53  ? -33.73460 1.93490   -36.83374 1.000 24.72856 ? 53  ASN A CA  1 
ATOM   393  C  C   . ASN A 1 53  ? -33.84678 2.77251   -35.56209 1.000 25.84282 ? 53  ASN A C   1 
ATOM   394  O  O   . ASN A 1 53  ? -34.88058 2.78979   -34.90201 1.000 24.23218 ? 53  ASN A O   1 
ATOM   395  C  CB  . ASN A 1 53  ? -35.07094 1.75250   -37.54734 1.000 28.21182 ? 53  ASN A CB  1 
ATOM   396  C  CG  . ASN A 1 53  ? -35.57194 3.01700   -38.18739 1.000 27.49185 ? 53  ASN A CG  1 
ATOM   397  O  OD1 . ASN A 1 53  ? -35.24014 4.11899   -37.76645 1.000 24.15504 ? 53  ASN A OD1 1 
ATOM   398  N  ND2 . ASN A 1 53  ? -36.39116 2.86361   -39.22382 1.000 40.52409 ? 53  ASN A ND2 1 
ATOM   399  N  N   . TYR A 1 54  ? -32.75711 3.46185   -35.20958 1.000 25.06395 ? 54  TYR A N   1 
ATOM   400  C  CA  . TYR A 1 54  ? -32.67798 4.10651   -33.90019 1.000 25.12614 ? 54  TYR A CA  1 
ATOM   401  C  C   . TYR A 1 54  ? -33.74178 5.18668   -33.73024 1.000 23.13400 ? 54  TYR A C   1 
ATOM   402  O  O   . TYR A 1 54  ? -34.33427 5.30904   -32.65322 1.000 20.67901 ? 54  TYR A O   1 
ATOM   403  C  CB  . TYR A 1 54  ? -31.28064 4.68409   -33.67651 1.000 23.49215 ? 54  TYR A CB  1 
ATOM   404  C  CG  . TYR A 1 54  ? -30.24915 3.61688   -33.39527 1.000 22.21819 ? 54  TYR A CG  1 
ATOM   405  C  CD1 . TYR A 1 54  ? -30.21295 2.97382   -32.16958 1.000 23.90427 ? 54  TYR A CD1 1 
ATOM   406  C  CD2 . TYR A 1 54  ? -29.33613 3.23101   -34.36502 1.000 22.83583 ? 54  TYR A CD2 1 
ATOM   407  C  CE1 . TYR A 1 54  ? -29.28856 1.99101   -31.90822 1.000 23.91808 ? 54  TYR A CE1 1 
ATOM   408  C  CE2 . TYR A 1 54  ? -28.39504 2.25257   -34.10668 1.000 26.07617 ? 54  TYR A CE2 1 
ATOM   409  C  CZ  . TYR A 1 54  ? -28.38655 1.62854   -32.87886 1.000 24.31476 ? 54  TYR A CZ  1 
ATOM   410  O  OH  . TYR A 1 54  ? -27.46597 0.64653   -32.60626 1.000 25.89999 ? 54  TYR A OH  1 
ATOM   411  N  N   . GLU A 1 55  ? -33.99489 5.97803   -34.77573 1.000 23.70621 ? 55  GLU A N   1 
ATOM   412  C  CA  . GLU A 1 55  ? -35.03091 7.00446   -34.68618 1.000 26.41858 ? 55  GLU A CA  1 
ATOM   413  C  C   . GLU A 1 55  ? -36.38873 6.38229   -34.36932 1.000 27.81433 ? 55  GLU A C   1 
ATOM   414  O  O   . GLU A 1 55  ? -37.18103 6.94561   -33.60413 1.000 23.72524 ? 55  GLU A O   1 
ATOM   415  C  CB  . GLU A 1 55  ? -35.10107 7.80112   -35.98979 1.000 25.64465 ? 55  GLU A CB  1 
ATOM   416  C  CG  . GLU A 1 55  ? -33.93040 8.74924   -36.24017 1.000 36.15768 ? 55  GLU A CG  1 
ATOM   417  C  CD  . GLU A 1 55  ? -32.73882 8.08839   -36.93535 1.000 43.16328 ? 55  GLU A CD  1 
ATOM   418  O  OE1 . GLU A 1 55  ? -32.79113 6.86607   -37.23675 1.000 39.00270 ? 55  GLU A OE1 1 
ATOM   419  O  OE2 . GLU A 1 55  ? -31.73759 8.80486   -37.18485 1.000 46.81746 ? 55  GLU A OE2 1 
ATOM   420  N  N   . ASP A 1 56  ? -36.65679 5.20074   -34.92418 1.000 26.61472 ? 56  ASP A N   1 
ATOM   421  C  CA  . ASP A 1 56  ? -37.93864 4.54140   -34.70969 1.000 29.23077 ? 56  ASP A CA  1 
ATOM   422  C  C   . ASP A 1 56  ? -38.01521 3.91786   -33.31998 1.000 28.64919 ? 56  ASP A C   1 
ATOM   423  O  O   . ASP A 1 56  ? -39.06172 3.98240   -32.66182 1.000 23.74774 ? 56  ASP A O   1 
ATOM   424  C  CB  . ASP A 1 56  ? -38.16515 3.49250   -35.80629 1.000 25.15588 ? 56  ASP A CB  1 
ATOM   425  C  CG  . ASP A 1 56  ? -39.44822 2.70662   -35.60326 1.000 33.15049 ? 56  ASP A CG  1 
ATOM   426  O  OD1 . ASP A 1 56  ? -40.51532 3.21916   -35.99746 1.000 29.46057 ? 56  ASP A OD1 1 
ATOM   427  O  OD2 . ASP A 1 56  ? -39.38577 1.58790   -35.04236 1.000 33.51987 ? 56  ASP A OD2 1 
ATOM   428  N  N   . LEU A 1 57  ? -36.91130 3.32344   -32.85527 1.000 28.11908 ? 57  LEU A N   1 
ATOM   429  C  CA  . LEU A 1 57  ? -36.87474 2.75397   -31.51190 1.000 24.52054 ? 57  LEU A CA  1 
ATOM   430  C  C   . LEU A 1 57  ? -37.02159 3.83521   -30.45036 1.000 24.06148 ? 57  LEU A C   1 
ATOM   431  O  O   . LEU A 1 57  ? -37.66972 3.62003   -29.41857 1.000 23.20575 ? 57  LEU A O   1 
ATOM   432  C  CB  . LEU A 1 57  ? -35.56619 1.98688   -31.30066 1.000 24.21147 ? 57  LEU A CB  1 
ATOM   433  C  CG  . LEU A 1 57  ? -35.26417 0.77280   -32.17274 1.000 31.60578 ? 57  LEU A CG  1 
ATOM   434  C  CD1 . LEU A 1 57  ? -33.82648 0.29183   -31.93372 1.000 30.27007 ? 57  LEU A CD1 1 
ATOM   435  C  CD2 . LEU A 1 57  ? -36.25692 -0.35102  -31.90892 1.000 27.05090 ? 57  LEU A CD2 1 
ATOM   436  N  N   . LEU A 1 58  ? -36.43702 5.00908   -30.69350 1.000 22.13499 ? 58  LEU A N   1 
ATOM   437  C  CA  . LEU A 1 58  ? -36.40227 6.05341   -29.67548 1.000 23.54862 ? 58  LEU A CA  1 
ATOM   438  C  C   . LEU A 1 58  ? -37.74965 6.75444   -29.52714 1.000 23.93274 ? 58  LEU A C   1 
ATOM   439  O  O   . LEU A 1 58  ? -38.18109 7.03576   -28.40333 1.000 27.74763 ? 58  LEU A O   1 
ATOM   440  C  CB  . LEU A 1 58  ? -35.31384 7.07342   -30.01235 1.000 23.13216 ? 58  LEU A CB  1 
ATOM   441  C  CG  . LEU A 1 58  ? -35.06584 8.13020   -28.93405 1.000 26.91406 ? 58  LEU A CG  1 
ATOM   442  C  CD1 . LEU A 1 58  ? -34.70340 7.46971   -27.61591 1.000 24.87234 ? 58  LEU A CD1 1 
ATOM   443  C  CD2 . LEU A 1 58  ? -33.97920 9.10599   -29.36786 1.000 22.98278 ? 58  LEU A CD2 1 
ATOM   444  N  N   . ILE A 1 59  ? -38.41570 7.05220   -30.64767 1.000 22.95388 ? 59  ILE A N   1 
ATOM   445  C  CA  . ILE A 1 59  ? -39.70651 7.73918   -30.61743 1.000 24.09440 ? 59  ILE A CA  1 
ATOM   446  C  C   . ILE A 1 59  ? -40.71788 6.94654   -29.79909 1.000 24.90406 ? 59  ILE A C   1 
ATOM   447  O  O   . ILE A 1 59  ? -41.64457 7.52077   -29.21091 1.000 24.94392 ? 59  ILE A O   1 
ATOM   448  C  CB  . ILE A 1 59  ? -40.20607 7.98279   -32.05988 1.000 23.65029 ? 59  ILE A CB  1 
ATOM   449  C  CG1 . ILE A 1 59  ? -41.40267 8.94051   -32.08861 1.000 27.90938 ? 59  ILE A CG1 1 
ATOM   450  C  CG2 . ILE A 1 59  ? -40.64537 6.68283   -32.70165 1.000 25.50808 ? 59  ILE A CG2 1 
ATOM   451  C  CD1 . ILE A 1 59  ? -41.03629 10.39343  -31.97086 1.000 34.18453 ? 59  ILE A CD1 1 
ATOM   452  N  N   . ARG A 1 60  ? -40.54874 5.62484   -29.73093 1.000 23.22750 ? 60  ARG A N   1 
ATOM   453  C  CA  . ARG A 1 60  ? -41.45673 4.74788   -29.00840 1.000 25.76939 ? 60  ARG A CA  1 
ATOM   454  C  C   . ARG A 1 60  ? -41.19061 4.72020   -27.50896 1.000 26.46586 ? 60  ARG A C   1 
ATOM   455  O  O   . ARG A 1 60  ? -42.00129 4.15668   -26.76504 1.000 25.06661 ? 60  ARG A O   1 
ATOM   456  C  CB  . ARG A 1 60  ? -41.36655 3.32704   -29.57605 1.000 20.48621 ? 60  ARG A CB  1 
ATOM   457  C  CG  . ARG A 1 60  ? -41.71119 3.23626   -31.05458 1.000 22.43482 ? 60  ARG A CG  1 
ATOM   458  C  CD  . ARG A 1 60  ? -41.49162 1.83809   -31.61224 1.000 22.00185 ? 60  ARG A CD  1 
ATOM   459  N  NE  . ARG A 1 60  ? -41.70348 1.80701   -33.05410 1.000 22.49127 ? 60  ARG A NE  1 
ATOM   460  C  CZ  . ARG A 1 60  ? -42.86639 1.55633   -33.63766 1.000 25.08979 ? 60  ARG A CZ  1 
ATOM   461  N  NH1 . ARG A 1 60  ? -43.95237 1.27656   -32.92865 1.000 23.01518 ? 60  ARG A NH1 1 
ATOM   462  N  NH2 . ARG A 1 60  ? -42.95006 1.60829   -34.96330 1.000 22.26223 ? 60  ARG A NH2 1 
ATOM   463  N  N   . LYS A 1 61  ? -40.09222 5.30955   -27.05141 1.000 23.72569 ? 61  LYS A N   1 
ATOM   464  C  CA  . LYS A 1 61  ? -39.72925 5.28904   -25.64489 1.000 26.42759 ? 61  LYS A CA  1 
ATOM   465  C  C   . LYS A 1 61  ? -40.28793 6.50914   -24.92812 1.000 29.37147 ? 61  LYS A C   1 
ATOM   466  O  O   . LYS A 1 61  ? -40.41680 7.59293   -25.50268 1.000 28.03718 ? 61  LYS A O   1 
ATOM   467  C  CB  . LYS A 1 61  ? -38.20564 5.26113   -25.46814 1.000 27.48025 ? 61  LYS A CB  1 
ATOM   468  C  CG  . LYS A 1 61  ? -37.50965 4.00867   -25.98478 1.000 28.42256 ? 61  LYS A CG  1 
ATOM   469  C  CD  . LYS A 1 61  ? -37.70634 2.82422   -25.06136 1.000 34.69501 ? 61  LYS A CD  1 
ATOM   470  C  CE  . LYS A 1 61  ? -37.10335 1.56632   -25.67262 1.000 29.66238 ? 61  LYS A CE  1 
ATOM   471  N  NZ  . LYS A 1 61  ? -37.62086 1.38122   -27.06410 1.000 39.81377 ? 61  LYS A NZ  1 
ATOM   472  N  N   . SER A 1 62  ? -40.59719 6.32969   -23.65278 1.000 27.92486 ? 62  SER A N   1 
ATOM   473  C  CA  . SER A 1 62  ? -40.84844 7.45994   -22.77428 1.000 34.06698 ? 62  SER A CA  1 
ATOM   474  C  C   . SER A 1 62  ? -39.76342 7.53050   -21.70689 1.000 35.92124 ? 62  SER A C   1 
ATOM   475  O  O   . SER A 1 62  ? -38.99308 6.58314   -21.49623 1.000 32.79173 ? 62  SER A O   1 
ATOM   476  C  CB  . SER A 1 62  ? -42.24710 7.37786   -22.14469 1.000 37.07246 ? 62  SER A CB  1 
ATOM   477  O  OG  . SER A 1 62  ? -42.55048 6.06797   -21.70699 1.000 42.49897 ? 62  SER A OG  1 
ATOM   478  N  N   . ASN A 1 63  ? -39.70890 8.69247   -21.04914 1.000 37.10978 ? 63  ASN A N   1 
ATOM   479  C  CA  . ASN A 1 63  ? -38.68672 8.95601   -20.04228 1.000 35.23820 ? 63  ASN A CA  1 
ATOM   480  C  C   . ASN A 1 63  ? -38.56387 7.82308   -19.02908 1.000 34.88653 ? 63  ASN A C   1 
ATOM   481  O  O   . ASN A 1 63  ? -37.45300 7.45611   -18.63171 1.000 34.11405 ? 63  ASN A O   1 
ATOM   482  C  CB  . ASN A 1 63  ? -38.99805 10.27562  -19.34548 1.000 34.47386 ? 63  ASN A CB  1 
ATOM   483  C  CG  . ASN A 1 63  ? -38.85293 11.46256  -20.27650 1.000 36.05006 ? 63  ASN A CG  1 
ATOM   484  O  OD1 . ASN A 1 63  ? -38.13078 11.39443  -21.26665 1.000 35.14475 ? 63  ASN A OD1 1 
ATOM   485  N  ND2 . ASN A 1 63  ? -39.52872 12.56014  -19.95946 1.000 31.11807 ? 63  ASN A ND2 1 
ATOM   486  N  N   . HIS A 1 64  ? -39.68376 7.23871   -18.61391 1.000 33.73657 ? 64  HIS A N   1 
ATOM   487  C  CA  . HIS A 1 64  ? -39.63019 6.21188   -17.57888 1.000 35.80681 ? 64  HIS A CA  1 
ATOM   488  C  C   . HIS A 1 64  ? -39.20542 4.84685   -18.10606 1.000 33.36420 ? 64  HIS A C   1 
ATOM   489  O  O   . HIS A 1 64  ? -39.09987 3.90502   -17.31000 1.000 32.24200 ? 64  HIS A O   1 
ATOM   490  C  CB  . HIS A 1 64  ? -40.98204 6.10050   -16.86598 1.000 32.11731 ? 64  HIS A CB  1 
ATOM   491  C  CG  . HIS A 1 64  ? -42.12535 5.79389   -17.77961 1.000 38.39974 ? 64  HIS A CG  1 
ATOM   492  N  ND1 . HIS A 1 64  ? -42.50332 4.50469   -18.09056 1.000 40.61678 ? 64  HIS A ND1 1 
ATOM   493  C  CD2 . HIS A 1 64  ? -42.98114 6.60834   -18.44276 1.000 38.29140 ? 64  HIS A CD2 1 
ATOM   494  C  CE1 . HIS A 1 64  ? -43.54203 4.53728   -18.90697 1.000 41.37164 ? 64  HIS A CE1 1 
ATOM   495  N  NE2 . HIS A 1 64  ? -43.85215 5.80146   -19.13614 1.000 40.47611 ? 64  HIS A NE2 1 
ATOM   496  N  N   . ASN A 1 65  ? -38.96586 4.70435   -19.41488 1.000 26.75828 ? 65  ASN A N   1 
ATOM   497  C  CA  . ASN A 1 65  ? -38.30984 3.49170   -19.89390 1.000 28.39105 ? 65  ASN A CA  1 
ATOM   498  C  C   . ASN A 1 65  ? -36.81502 3.46938   -19.56533 1.000 27.40639 ? 65  ASN A C   1 
ATOM   499  O  O   . ASN A 1 65  ? -36.19491 2.40903   -19.67402 1.000 30.63278 ? 65  ASN A O   1 
ATOM   500  C  CB  . ASN A 1 65  ? -38.49898 3.32733   -21.40545 1.000 27.79380 ? 65  ASN A CB  1 
ATOM   501  C  CG  . ASN A 1 65  ? -39.94811 3.08833   -21.80091 1.000 33.57533 ? 65  ASN A CG  1 
ATOM   502  O  OD1 . ASN A 1 65  ? -40.49024 3.78817   -22.66006 1.000 32.52861 ? 65  ASN A OD1 1 
ATOM   503  N  ND2 . ASN A 1 65  ? -40.58011 2.09928   -21.18062 1.000 32.16095 ? 65  ASN A ND2 1 
ATOM   504  N  N   . PHE A 1 66  ? -36.23263 4.60398   -19.16880 1.000 31.18281 ? 66  PHE A N   1 
ATOM   505  C  CA  . PHE A 1 66  ? -34.80492 4.72096   -18.87593 1.000 27.49337 ? 66  PHE A CA  1 
ATOM   506  C  C   . PHE A 1 66  ? -34.59875 4.77024   -17.36214 1.000 34.85825 ? 66  PHE A C   1 
ATOM   507  O  O   . PHE A 1 66  ? -35.01149 5.73342   -16.70560 1.000 35.75480 ? 66  PHE A O   1 
ATOM   508  C  CB  . PHE A 1 66  ? -34.21827 5.97171   -19.53006 1.000 23.72044 ? 66  PHE A CB  1 
ATOM   509  C  CG  . PHE A 1 66  ? -34.29342 5.97317   -21.03856 1.000 32.77192 ? 66  PHE A CG  1 
ATOM   510  C  CD1 . PHE A 1 66  ? -33.40195 5.22726   -21.79091 1.000 29.19101 ? 66  PHE A CD1 1 
ATOM   511  C  CD2 . PHE A 1 66  ? -35.24150 6.74255   -21.70147 1.000 28.19965 ? 66  PHE A CD2 1 
ATOM   512  C  CE1 . PHE A 1 66  ? -33.46527 5.23418   -23.17479 1.000 35.41752 ? 66  PHE A CE1 1 
ATOM   513  C  CE2 . PHE A 1 66  ? -35.30715 6.75739   -23.08764 1.000 28.31759 ? 66  PHE A CE2 1 
ATOM   514  C  CZ  . PHE A 1 66  ? -34.42354 6.00275   -23.82497 1.000 32.28635 ? 66  PHE A CZ  1 
ATOM   515  N  N   . LEU A 1 67  ? -33.95032 3.73848   -16.81231 1.000 32.56973 ? 67  LEU A N   1 
ATOM   516  C  CA  . LEU A 1 67  ? -33.55682 3.69622   -15.40381 1.000 29.34257 ? 67  LEU A CA  1 
ATOM   517  C  C   . LEU A 1 67  ? -32.10062 4.13583   -15.29037 1.000 29.57508 ? 67  LEU A C   1 
ATOM   518  O  O   . LEU A 1 67  ? -31.19954 3.43077   -15.75347 1.000 29.49616 ? 67  LEU A O   1 
ATOM   519  C  CB  . LEU A 1 67  ? -33.72993 2.29367   -14.82409 1.000 33.80119 ? 67  LEU A CB  1 
ATOM   520  C  CG  . LEU A 1 67  ? -35.08009 1.88617   -14.23467 1.000 43.77747 ? 67  LEU A CG  1 
ATOM   521  C  CD1 . LEU A 1 67  ? -36.13622 1.71768   -15.32306 1.000 48.65187 ? 67  LEU A CD1 1 
ATOM   522  C  CD2 . LEU A 1 67  ? -34.92150 0.61114   -13.42627 1.000 51.48764 ? 67  LEU A CD2 1 
ATOM   523  N  N   . VAL A 1 68  ? -31.86878 5.29571   -14.68397 1.000 26.45926 ? 68  VAL A N   1 
ATOM   524  C  CA  . VAL A 1 68  ? -30.52286 5.80653   -14.43595 1.000 28.44149 ? 68  VAL A CA  1 
ATOM   525  C  C   . VAL A 1 68  ? -30.23915 5.73041   -12.94076 1.000 33.45178 ? 68  VAL A C   1 
ATOM   526  O  O   . VAL A 1 68  ? -31.02229 6.23656   -12.12674 1.000 31.85172 ? 68  VAL A O   1 
ATOM   527  C  CB  . VAL A 1 68  ? -30.35628 7.24947   -14.93888 1.000 24.19820 ? 68  VAL A CB  1 
ATOM   528  C  CG1 . VAL A 1 68  ? -28.92479 7.72201   -14.69187 1.000 24.55826 ? 68  VAL A CG1 1 
ATOM   529  C  CG2 . VAL A 1 68  ? -30.71680 7.34576   -16.41394 1.000 30.32509 ? 68  VAL A CG2 1 
ATOM   530  N  N   . GLN A 1 69  ? -29.11303 5.12067   -12.57939 1.000 27.86974 ? 69  GLN A N   1 
ATOM   531  C  CA  . GLN A 1 69  ? -28.72675 4.95616   -11.18315 1.000 30.91559 ? 69  GLN A CA  1 
ATOM   532  C  C   . GLN A 1 69  ? -27.33834 5.54143   -10.97348 1.000 30.48167 ? 69  GLN A C   1 
ATOM   533  O  O   . GLN A 1 69  ? -26.37154 5.09104   -11.59936 1.000 24.18376 ? 69  GLN A O   1 
ATOM   534  C  CB  . GLN A 1 69  ? -28.73956 3.48380   -10.77646 1.000 34.09288 ? 69  GLN A CB  1 
ATOM   535  C  CG  . GLN A 1 69  ? -30.06217 2.78666   -10.97282 1.000 38.69981 ? 69  GLN A CG  1 
ATOM   536  C  CD  . GLN A 1 69  ? -29.99377 1.33286   -10.56850 1.000 48.24756 ? 69  GLN A CD  1 
ATOM   537  O  OE1 . GLN A 1 69  ? -29.41254 0.99526   -9.53419  1.000 53.70056 ? 69  GLN A OE1 1 
ATOM   538  N  NE2 . GLN A 1 69  ? -30.57007 0.45729   -11.39036 1.000 49.27375 ? 69  GLN A NE2 1 
ATOM   539  N  N   . ALA A 1 70  ? -27.24339 6.54188   -10.10219 1.000 30.64700 ? 70  ALA A N   1 
ATOM   540  C  CA  . ALA A 1 70  ? -25.96429 7.08065   -9.65727  1.000 33.56454 ? 70  ALA A CA  1 
ATOM   541  C  C   . ALA A 1 70  ? -25.70818 6.53695   -8.25969  1.000 38.40245 ? 70  ALA A C   1 
ATOM   542  O  O   . ALA A 1 70  ? -26.31933 6.99616   -7.28724  1.000 35.90653 ? 70  ALA A O   1 
ATOM   543  C  CB  . ALA A 1 70  ? -25.96659 8.60611   -9.66818  1.000 30.63519 ? 70  ALA A CB  1 
ATOM   544  N  N   . GLY A 1 71  ? -24.80577 5.56493   -8.16357  1.000 37.70150 ? 71  GLY A N   1 
ATOM   545  C  CA  . GLY A 1 71  ? -24.58288 4.89785   -6.89321  1.000 35.46273 ? 71  GLY A CA  1 
ATOM   546  C  C   . GLY A 1 71  ? -25.84876 4.18548   -6.46299  1.000 39.23013 ? 71  GLY A C   1 
ATOM   547  O  O   . GLY A 1 71  ? -26.39824 3.34983   -7.19169  1.000 40.00466 ? 71  GLY A O   1 
ATOM   548  N  N   . ASN A 1 72  ? -26.33402 4.52285   -5.26914  1.000 42.01896 ? 72  ASN A N   1 
ATOM   549  C  CA  . ASN A 1 72  ? -27.60636 4.00083   -4.79270  1.000 46.83222 ? 72  ASN A CA  1 
ATOM   550  C  C   . ASN A 1 72  ? -28.79393 4.84949   -5.22862  1.000 41.99460 ? 72  ASN A C   1 
ATOM   551  O  O   . ASN A 1 72  ? -29.93567 4.38883   -5.12956  1.000 49.17204 ? 72  ASN A O   1 
ATOM   552  C  CB  . ASN A 1 72  ? -27.59572 3.89183   -3.26180  1.000 43.74145 ? 72  ASN A CB  1 
ATOM   553  N  N   . VAL A 1 73  ? -28.55692 6.06246   -5.71548  1.000 40.20228 ? 73  VAL A N   1 
ATOM   554  C  CA  . VAL A 1 73  ? -29.62621 7.00239   -6.03070  1.000 40.93562 ? 73  VAL A CA  1 
ATOM   555  C  C   . VAL A 1 73  ? -30.12394 6.76352   -7.45030  1.000 42.66155 ? 73  VAL A C   1 
ATOM   556  O  O   . VAL A 1 73  ? -29.33865 6.75192   -8.40572  1.000 37.28560 ? 73  VAL A O   1 
ATOM   557  C  CB  . VAL A 1 73  ? -29.14777 8.45418   -5.86258  1.000 41.49257 ? 73  VAL A CB  1 
ATOM   558  C  CG1 . VAL A 1 73  ? -30.25586 9.42593   -6.26377  1.000 43.83323 ? 73  VAL A CG1 1 
ATOM   559  C  CG2 . VAL A 1 73  ? -28.69863 8.70111   -4.43322  1.000 46.65377 ? 73  VAL A CG2 1 
ATOM   560  N  N   . GLN A 1 74  ? -31.43382 6.59562   -7.59219  1.000 39.53867 ? 74  GLN A N   1 
ATOM   561  C  CA  . GLN A 1 74  ? -32.06020 6.62189   -8.90381  1.000 39.38116 ? 74  GLN A CA  1 
ATOM   562  C  C   . GLN A 1 74  ? -32.27871 8.07197   -9.32453  1.000 37.92641 ? 74  GLN A C   1 
ATOM   563  O  O   . GLN A 1 74  ? -32.71733 8.89694   -8.51768  1.000 40.36660 ? 74  GLN A O   1 
ATOM   564  C  CB  . GLN A 1 74  ? -33.37927 5.85539   -8.86622  1.000 39.94349 ? 74  GLN A CB  1 
ATOM   565  C  CG  . GLN A 1 74  ? -34.20160 5.95580   -10.12903 1.000 48.15935 ? 74  GLN A CG  1 
ATOM   566  C  CD  . GLN A 1 74  ? -35.45254 5.10440   -10.06838 1.000 54.48115 ? 74  GLN A CD  1 
ATOM   567  O  OE1 . GLN A 1 74  ? -35.55403 4.18691   -9.25187  1.000 57.24410 ? 74  GLN A OE1 1 
ATOM   568  N  NE2 . GLN A 1 74  ? -36.41713 5.40580   -10.93423 1.000 57.61835 ? 74  GLN A NE2 1 
ATOM   569  N  N   . LEU A 1 75  ? -31.94468 8.39030   -10.57512 1.000 33.77725 ? 75  LEU A N   1 
ATOM   570  C  CA  . LEU A 1 75  ? -32.14364 9.72552   -11.12848 1.000 31.95629 ? 75  LEU A CA  1 
ATOM   571  C  C   . LEU A 1 75  ? -33.35753 9.70843   -12.04443 1.000 35.43258 ? 75  LEU A C   1 
ATOM   572  O  O   . LEU A 1 75  ? -33.51550 8.78557   -12.84841 1.000 39.01728 ? 75  LEU A O   1 
ATOM   573  C  CB  . LEU A 1 75  ? -30.91821 10.19462  -11.91424 1.000 31.90460 ? 75  LEU A CB  1 
ATOM   574  C  CG  . LEU A 1 75  ? -29.56965 10.23758  -11.19595 1.000 33.83787 ? 75  LEU A CG  1 
ATOM   575  C  CD1 . LEU A 1 75  ? -28.47310 10.69170  -12.15288 1.000 26.91091 ? 75  LEU A CD1 1 
ATOM   576  C  CD2 . LEU A 1 75  ? -29.65268 11.15482  -9.97916  1.000 33.08704 ? 75  LEU A CD2 1 
ATOM   577  N  N   . ARG A 1 76  ? -34.19732 10.73363  -11.94532 1.000 33.75770 ? 76  ARG A N   1 
ATOM   578  C  CA  . ARG A 1 76  ? -35.40698 10.77819  -12.75734 1.000 37.71208 ? 76  ARG A CA  1 
ATOM   579  C  C   . ARG A 1 76  ? -35.08439 11.37688  -14.12273 1.000 29.63465 ? 76  ARG A C   1 
ATOM   580  O  O   . ARG A 1 76  ? -34.56996 12.49929  -14.21576 1.000 31.08247 ? 76  ARG A O   1 
ATOM   581  C  CB  . ARG A 1 76  ? -36.50097 11.57629  -12.04838 1.000 40.17002 ? 76  ARG A CB  1 
ATOM   582  C  CG  . ARG A 1 76  ? -37.90666 11.25563  -12.54598 1.000 44.50642 ? 76  ARG A CG  1 
ATOM   583  C  CD  . ARG A 1 76  ? -38.97599 11.94201  -11.71388 1.000 48.01430 ? 76  ARG A CD  1 
ATOM   584  N  NE  . ARG A 1 76  ? -39.05173 13.37109  -11.99251 1.000 54.59958 ? 76  ARG A NE  1 
ATOM   585  C  CZ  . ARG A 1 76  ? -39.91575 13.92215  -12.83564 1.000 60.73546 ? 76  ARG A CZ  1 
ATOM   586  N  NH1 . ARG A 1 76  ? -40.78957 13.18865  -13.50904 1.000 58.71363 ? 76  ARG A NH1 1 
ATOM   587  N  NH2 . ARG A 1 76  ? -39.90627 15.24180  -13.00450 1.000 55.91304 ? 76  ARG A NH2 1 
ATOM   588  N  N   . VAL A 1 77  ? -35.35458 10.61891  -15.17813 1.000 27.98225 ? 77  VAL A N   1 
ATOM   589  C  CA  . VAL A 1 77  ? -35.20668 11.13669  -16.53499 1.000 30.05080 ? 77  VAL A CA  1 
ATOM   590  C  C   . VAL A 1 77  ? -36.42929 11.97886  -16.86609 1.000 30.79714 ? 77  VAL A C   1 
ATOM   591  O  O   . VAL A 1 77  ? -37.56722 11.54371  -16.65611 1.000 34.49069 ? 77  VAL A O   1 
ATOM   592  C  CB  . VAL A 1 77  ? -35.02462 9.98970   -17.54241 1.000 31.76216 ? 77  VAL A CB  1 
ATOM   593  C  CG1 . VAL A 1 77  ? -34.99754 10.52141  -18.96728 1.000 30.72749 ? 77  VAL A CG1 1 
ATOM   594  C  CG2 . VAL A 1 77  ? -33.74006 9.22054   -17.23734 1.000 33.56579 ? 77  VAL A CG2 1 
ATOM   595  N  N   . ILE A 1 78  ? -36.19688 13.19636  -17.36134 1.000 32.75035 ? 78  ILE A N   1 
ATOM   596  C  CA  . ILE A 1 78  ? -37.25855 14.12627  -17.72384 1.000 32.23102 ? 78  ILE A CA  1 
ATOM   597  C  C   . ILE A 1 78  ? -37.22363 14.49250  -19.20273 1.000 37.59636 ? 78  ILE A C   1 
ATOM   598  O  O   . ILE A 1 78  ? -37.94341 15.39939  -19.63332 1.000 30.64664 ? 78  ILE A O   1 
ATOM   599  C  CB  . ILE A 1 78  ? -37.21111 15.39616  -16.85188 1.000 36.45201 ? 78  ILE A CB  1 
ATOM   600  C  CG1 . ILE A 1 78  ? -35.86529 16.10257  -17.00694 1.000 31.70004 ? 78  ILE A CG1 1 
ATOM   601  C  CG2 . ILE A 1 78  ? -37.49279 15.04794  -15.39430 1.000 31.49919 ? 78  ILE A CG2 1 
ATOM   602  C  CD1 . ILE A 1 78  ? -35.80504 17.44795  -16.32071 1.000 29.87494 ? 78  ILE A CD1 1 
ATOM   603  N  N   . GLY A 1 79  ? -36.40898 13.80165  -19.99550 1.000 30.50584 ? 79  GLY A N   1 
ATOM   604  C  CA  . GLY A 1 79  ? -36.34109 14.08328  -21.41417 1.000 32.77855 ? 79  GLY A CA  1 
ATOM   605  C  C   . GLY A 1 79  ? -35.14885 13.41669  -22.06810 1.000 29.76722 ? 79  GLY A C   1 
ATOM   606  O  O   . GLY A 1 79  ? -34.14343 13.14804  -21.40433 1.000 30.57361 ? 79  GLY A O   1 
ATOM   607  N  N   . HIS A 1 80  ? -35.25020 13.13217  -23.36432 1.000 33.99860 ? 80  HIS A N   1 
ATOM   608  C  CA  . HIS A 1 80  ? -34.17019 12.45598  -24.06360 1.000 32.12754 ? 80  HIS A CA  1 
ATOM   609  C  C   . HIS A 1 80  ? -34.09148 12.97709  -25.48651 1.000 34.73792 ? 80  HIS A C   1 
ATOM   610  O  O   . HIS A 1 80  ? -35.11199 13.31874  -26.09159 1.000 32.56950 ? 80  HIS A O   1 
ATOM   611  C  CB  . HIS A 1 80  ? -34.36024 10.93053  -24.06086 1.000 28.44147 ? 80  HIS A CB  1 
ATOM   612  C  CG  . HIS A 1 80  ? -35.65350 10.46921  -24.66258 1.000 32.26126 ? 80  HIS A CG  1 
ATOM   613  N  ND1 . HIS A 1 80  ? -36.72004 10.04368  -23.89764 1.000 35.96226 ? 80  HIS A ND1 1 
ATOM   614  C  CD2 . HIS A 1 80  ? -36.04767 10.35016  -25.95404 1.000 33.27932 ? 80  HIS A CD2 1 
ATOM   615  C  CE1 . HIS A 1 80  ? -37.71644 9.68780   -24.68985 1.000 34.67130 ? 80  HIS A CE1 1 
ATOM   616  N  NE2 . HIS A 1 80  ? -37.33636 9.86861   -25.94267 1.000 30.50202 ? 80  HIS A NE2 1 
ATOM   617  N  N   . SER A 1 81  ? -32.86996 13.05405  -25.99990 1.000 28.39794 ? 81  SER A N   1 
ATOM   618  C  CA  . SER A 1 81  ? -32.62772 13.31062  -27.40749 1.000 31.96699 ? 81  SER A CA  1 
ATOM   619  C  C   . SER A 1 81  ? -31.39485 12.52695  -27.83052 1.000 30.49944 ? 81  SER A C   1 
ATOM   620  O  O   . SER A 1 81  ? -30.57773 12.10887  -27.00356 1.000 28.08007 ? 81  SER A O   1 
ATOM   621  C  CB  . SER A 1 81  ? -32.44432 14.80513  -27.70944 1.000 29.13448 ? 81  SER A CB  1 
ATOM   622  O  OG  . SER A 1 81  ? -31.20010 15.27823  -27.23494 1.000 35.60876 ? 81  SER A OG  1 
ATOM   623  N  N   . MET A 1 82  ? -31.28146 12.32358  -29.13374 1.000 26.39716 ? 82  MET A N   1 
ATOM   624  C  CA  . MET A 1 82  ? -30.19120 11.57222  -29.72800 1.000 25.87375 ? 82  MET A CA  1 
ATOM   625  C  C   . MET A 1 82  ? -29.35464 12.52322  -30.56605 1.000 25.80281 ? 82  MET A C   1 
ATOM   626  O  O   . MET A 1 82  ? -29.89014 13.41049  -31.23268 1.000 24.05550 ? 82  MET A O   1 
ATOM   627  C  CB  . MET A 1 82  ? -30.73870 10.42257  -30.57575 1.000 28.20828 ? 82  MET A CB  1 
ATOM   628  C  CG  . MET A 1 82  ? -29.71342 9.53499   -31.23967 1.000 27.97016 ? 82  MET A CG  1 
ATOM   629  S  SD  . MET A 1 82  ? -30.49472 8.14576   -32.09845 1.000 29.72452 ? 82  MET A SD  1 
ATOM   630  C  CE  . MET A 1 82  ? -31.57652 9.01034   -33.24546 1.000 31.70231 ? 82  MET A CE  1 
ATOM   631  N  N   . GLN A 1 83  ? -28.03955 12.36765  -30.48946 1.000 21.12241 ? 83  GLN A N   1 
ATOM   632  C  CA  . GLN A 1 83  ? -27.10854 13.14359  -31.29662 1.000 24.92677 ? 83  GLN A CA  1 
ATOM   633  C  C   . GLN A 1 83  ? -26.13080 12.15484  -31.91019 1.000 28.39126 ? 83  GLN A C   1 
ATOM   634  O  O   . GLN A 1 83  ? -25.30370 11.57653  -31.19399 1.000 22.42412 ? 83  GLN A O   1 
ATOM   635  C  CB  . GLN A 1 83  ? -26.37519 14.19736  -30.46732 1.000 28.72325 ? 83  GLN A CB  1 
ATOM   636  C  CG  . GLN A 1 83  ? -25.34035 14.98011  -31.27701 1.000 29.27254 ? 83  GLN A CG  1 
ATOM   637  C  CD  . GLN A 1 83  ? -24.58811 15.98900  -30.44740 1.000 30.20003 ? 83  GLN A CD  1 
ATOM   638  O  OE1 . GLN A 1 83  ? -24.62943 15.95345  -29.21963 1.000 28.63197 ? 83  GLN A OE1 1 
ATOM   639  N  NE2 . GLN A 1 83  ? -23.89435 16.90529  -31.11574 1.000 33.15832 ? 83  GLN A NE2 1 
ATOM   640  N  N   . ASN A 1 84  ? -26.24141 11.95847  -33.22694 1.000 25.06122 ? 84  ASN A N   1 
ATOM   641  C  CA  . ASN A 1 84  ? -25.47853 10.93351  -33.92553 1.000 24.49934 ? 84  ASN A CA  1 
ATOM   642  C  C   . ASN A 1 84  ? -25.64089 9.60492   -33.19238 1.000 22.04736 ? 84  ASN A C   1 
ATOM   643  O  O   . ASN A 1 84  ? -26.77212 9.14848   -33.00716 1.000 23.08384 ? 84  ASN A O   1 
ATOM   644  C  CB  . ASN A 1 84  ? -24.02153 11.38222  -34.06476 1.000 19.39530 ? 84  ASN A CB  1 
ATOM   645  C  CG  . ASN A 1 84  ? -23.90454 12.69050  -34.82855 1.000 24.08053 ? 84  ASN A CG  1 
ATOM   646  O  OD1 . ASN A 1 84  ? -24.44324 12.81826  -35.92478 1.000 24.90382 ? 84  ASN A OD1 1 
ATOM   647  N  ND2 . ASN A 1 84  ? -23.23054 13.67535  -34.24394 1.000 24.47377 ? 84  ASN A ND2 1 
ATOM   648  N  N   . CYS A 1 85  ? -24.55428 8.98180   -32.73599 1.000 19.41702 ? 85  CYS A N   1 
ATOM   649  C  CA  . CYS A 1 85  ? -24.66286 7.66837   -32.11109 1.000 19.69359 ? 85  CYS A CA  1 
ATOM   650  C  C   . CYS A 1 85  ? -24.70088 7.71979   -30.58299 1.000 21.88353 ? 85  CYS A C   1 
ATOM   651  O  O   . CYS A 1 85  ? -24.58025 6.67621   -29.93743 1.000 20.66422 ? 85  CYS A O   1 
ATOM   652  C  CB  . CYS A 1 85  ? -23.52330 6.76820   -32.57983 1.000 21.70749 ? 85  CYS A CB  1 
ATOM   653  S  SG  . CYS A 1 85  ? -23.52358 6.48401   -34.36883 1.000 24.30970 ? 85  CYS A SG  1 
ATOM   654  N  N   . VAL A 1 86  ? -24.90085 8.89193   -29.99021 1.000 21.04799 ? 86  VAL A N   1 
ATOM   655  C  CA  . VAL A 1 86  ? -24.93987 9.03729   -28.53827 1.000 20.65551 ? 86  VAL A CA  1 
ATOM   656  C  C   . VAL A 1 86  ? -26.33592 9.46498   -28.10369 1.000 23.02490 ? 86  VAL A C   1 
ATOM   657  O  O   . VAL A 1 86  ? -26.95753 10.33867  -28.72100 1.000 21.88280 ? 86  VAL A O   1 
ATOM   658  C  CB  . VAL A 1 86  ? -23.86808 10.03116  -28.04842 1.000 21.65704 ? 86  VAL A CB  1 
ATOM   659  C  CG1 . VAL A 1 86  ? -24.21088 10.56543  -26.68396 1.000 26.37071 ? 86  VAL A CG1 1 
ATOM   660  C  CG2 . VAL A 1 86  ? -22.52307 9.31866   -27.98294 1.000 21.86217 ? 86  VAL A CG2 1 
ATOM   661  N  N   . LEU A 1 87  ? -26.82733 8.83403   -27.04422 1.000 20.96009 ? 87  LEU A N   1 
ATOM   662  C  CA  . LEU A 1 87  ? -28.08162 9.21715   -26.41626 1.000 24.55656 ? 87  LEU A CA  1 
ATOM   663  C  C   . LEU A 1 87  ? -27.81241 10.20901  -25.28668 1.000 29.62028 ? 87  LEU A C   1 
ATOM   664  O  O   . LEU A 1 87  ? -26.84682 10.06501  -24.52695 1.000 22.04718 ? 87  LEU A O   1 
ATOM   665  C  CB  . LEU A 1 87  ? -28.78791 7.97097   -25.88734 1.000 25.33584 ? 87  LEU A CB  1 
ATOM   666  C  CG  . LEU A 1 87  ? -30.20251 8.04283   -25.31131 1.000 30.39401 ? 87  LEU A CG  1 
ATOM   667  C  CD1 . LEU A 1 87  ? -31.17770 8.63336   -26.30644 1.000 30.68629 ? 87  LEU A CD1 1 
ATOM   668  C  CD2 . LEU A 1 87  ? -30.63395 6.64889   -24.91287 1.000 31.51317 ? 87  LEU A CD2 1 
ATOM   669  N  N   . LYS A 1 88  ? -28.65385 11.23347  -25.19696 1.000 24.21099 ? 88  LYS A N   1 
ATOM   670  C  CA  . LYS A 1 88  ? -28.52122 12.27562  -24.18656 1.000 25.42537 ? 88  LYS A CA  1 
ATOM   671  C  C   . LYS A 1 88  ? -29.78004 12.27375  -23.33072 1.000 26.10478 ? 88  LYS A C   1 
ATOM   672  O  O   . LYS A 1 88  ? -30.85398 12.67134  -23.79254 1.000 25.11796 ? 88  LYS A O   1 
ATOM   673  C  CB  . LYS A 1 88  ? -28.27970 13.63816  -24.83280 1.000 26.32864 ? 88  LYS A CB  1 
ATOM   674  C  CG  . LYS A 1 88  ? -26.99165 13.67597  -25.64496 1.000 28.47481 ? 88  LYS A CG  1 
ATOM   675  C  CD  . LYS A 1 88  ? -26.49299 15.09055  -25.91658 1.000 29.37272 ? 88  LYS A CD  1 
ATOM   676  C  CE  . LYS A 1 88  ? -27.37177 15.80769  -26.90967 1.000 29.93208 ? 88  LYS A CE  1 
ATOM   677  N  NZ  . LYS A 1 88  ? -26.62719 16.89641  -27.60036 1.000 36.25165 ? 88  LYS A NZ  1 
ATOM   678  N  N   . LEU A 1 89  ? -29.64737 11.81541  -22.09219 1.000 28.06536 ? 89  LEU A N   1 
ATOM   679  C  CA  . LEU A 1 89  ? -30.76307 11.71701  -21.16348 1.000 23.33045 ? 89  LEU A CA  1 
ATOM   680  C  C   . LEU A 1 89  ? -30.75608 12.93553  -20.25394 1.000 28.62384 ? 89  LEU A C   1 
ATOM   681  O  O   . LEU A 1 89  ? -29.78164 13.16764  -19.52791 1.000 25.62538 ? 89  LEU A O   1 
ATOM   682  C  CB  . LEU A 1 89  ? -30.67252 10.43276  -20.34752 1.000 22.97885 ? 89  LEU A CB  1 
ATOM   683  C  CG  . LEU A 1 89  ? -30.73409 9.14726   -21.16703 1.000 24.95256 ? 89  LEU A CG  1 
ATOM   684  C  CD1 . LEU A 1 89  ? -30.72780 7.93111   -20.26534 1.000 21.94836 ? 89  LEU A CD1 1 
ATOM   685  C  CD2 . LEU A 1 89  ? -31.97533 9.15075   -22.04093 1.000 30.44716 ? 89  LEU A CD2 1 
ATOM   686  N  N   . LYS A 1 90  ? -31.83060 13.72136  -20.30737 1.000 28.59391 ? 90  LYS A N   1 
ATOM   687  C  CA  . LYS A 1 90  ? -31.98264 14.85111  -19.39807 1.000 30.26431 ? 90  LYS A CA  1 
ATOM   688  C  C   . LYS A 1 90  ? -32.49239 14.34331  -18.05499 1.000 28.00780 ? 90  LYS A C   1 
ATOM   689  O  O   . LYS A 1 90  ? -33.49145 13.61796  -17.99914 1.000 29.43148 ? 90  LYS A O   1 
ATOM   690  C  CB  . LYS A 1 90  ? -32.94257 15.88533  -19.99319 1.000 32.17595 ? 90  LYS A CB  1 
ATOM   691  C  CG  . LYS A 1 90  ? -33.07452 17.17420  -19.20021 1.000 34.84557 ? 90  LYS A CG  1 
ATOM   692  C  CD  . LYS A 1 90  ? -31.84565 18.05716  -19.35219 1.000 42.87147 ? 90  LYS A CD  1 
ATOM   693  C  CE  . LYS A 1 90  ? -31.78749 18.74507  -20.71218 1.000 44.72593 ? 90  LYS A CE  1 
ATOM   694  N  NZ  . LYS A 1 90  ? -30.56881 19.60220  -20.83639 1.000 48.18073 ? 90  LYS A NZ  1 
ATOM   695  N  N   . VAL A 1 91  ? -31.79679 14.70267  -16.97416 1.000 27.22938 ? 91  VAL A N   1 
ATOM   696  C  CA  . VAL A 1 91  ? -32.19032 14.26948  -15.64155 1.000 30.18534 ? 91  VAL A CA  1 
ATOM   697  C  C   . VAL A 1 91  ? -32.50651 15.49024  -14.78433 1.000 34.34019 ? 91  VAL A C   1 
ATOM   698  O  O   . VAL A 1 91  ? -32.04729 16.60194  -15.04968 1.000 33.85706 ? 91  VAL A O   1 
ATOM   699  C  CB  . VAL A 1 91  ? -31.12255 13.38384  -14.96580 1.000 32.87924 ? 91  VAL A CB  1 
ATOM   700  C  CG1 . VAL A 1 91  ? -31.07389 12.01141  -15.64252 1.000 29.93231 ? 91  VAL A CG1 1 
ATOM   701  C  CG2 . VAL A 1 91  ? -29.74852 14.06587  -14.97055 1.000 29.63472 ? 91  VAL A CG2 1 
ATOM   702  N  N   . ASP A 1 92  ? -33.31309 15.26498  -13.73823 1.000 31.64439 ? 92  ASP A N   1 
ATOM   703  C  CA  . ASP A 1 92  ? -33.81336 16.36090  -12.91099 1.000 37.91601 ? 92  ASP A CA  1 
ATOM   704  C  C   . ASP A 1 92  ? -32.79445 16.88749  -11.90699 1.000 39.31003 ? 92  ASP A C   1 
ATOM   705  O  O   . ASP A 1 92  ? -33.07726 17.89127  -11.24474 1.000 39.46402 ? 92  ASP A O   1 
ATOM   706  C  CB  . ASP A 1 92  ? -35.09300 15.94127  -12.16352 1.000 39.18370 ? 92  ASP A CB  1 
ATOM   707  C  CG  . ASP A 1 92  ? -34.86008 14.82259  -11.14807 1.000 43.29954 ? 92  ASP A CG  1 
ATOM   708  O  OD1 . ASP A 1 92  ? -33.69772 14.39753  -10.92434 1.000 39.40549 ? 92  ASP A OD1 1 
ATOM   709  O  OD2 . ASP A 1 92  ? -35.86520 14.35890  -10.56751 1.000 42.76944 ? 92  ASP A OD2 1 
ATOM   710  N  N   . THR A 1 93  ? -31.63297 16.24689  -11.77568 1.000 34.63897 ? 93  THR A N   1 
ATOM   711  C  CA  . THR A 1 93  ? -30.59507 16.66402  -10.84225 1.000 31.28400 ? 93  THR A CA  1 
ATOM   712  C  C   . THR A 1 93  ? -29.29674 16.85118  -11.60838 1.000 32.23935 ? 93  THR A C   1 
ATOM   713  O  O   . THR A 1 93  ? -28.90445 15.97170  -12.37759 1.000 32.49898 ? 93  THR A O   1 
ATOM   714  C  CB  . THR A 1 93  ? -30.38349 15.62132  -9.73553  1.000 32.06981 ? 93  THR A CB  1 
ATOM   715  O  OG1 . THR A 1 93  ? -31.62424 15.33237  -9.07866  1.000 39.69067 ? 93  THR A OG1 1 
ATOM   716  C  CG2 . THR A 1 93  ? -29.38447 16.12985  -8.71665  1.000 35.09356 ? 93  THR A CG2 1 
ATOM   717  N  N   . ALA A 1 94  ? -28.63724 17.98676  -11.40696 1.000 28.56852 ? 94  ALA A N   1 
ATOM   718  C  CA  . ALA A 1 94  ? -27.28687 18.16127  -11.91790 1.000 30.01396 ? 94  ALA A CA  1 
ATOM   719  C  C   . ALA A 1 94  ? -26.29091 17.42840  -11.02928 1.000 29.84878 ? 94  ALA A C   1 
ATOM   720  O  O   . ALA A 1 94  ? -26.44914 17.35934  -9.80642  1.000 33.84545 ? 94  ALA A O   1 
ATOM   721  C  CB  . ALA A 1 94  ? -26.90743 19.63688  -11.98954 1.000 29.11465 ? 94  ALA A CB  1 
ATOM   722  N  N   . ASN A 1 95  ? -25.25708 16.88681  -11.65252 1.000 28.03819 ? 95  ASN A N   1 
ATOM   723  C  CA  . ASN A 1 95  ? -24.22898 16.17200  -10.90924 1.000 25.59666 ? 95  ASN A CA  1 
ATOM   724  C  C   . ASN A 1 95  ? -23.38603 17.16259  -10.11675 1.000 23.05469 ? 95  ASN A C   1 
ATOM   725  O  O   . ASN A 1 95  ? -22.71704 18.01018  -10.71989 1.000 27.64872 ? 95  ASN A O   1 
ATOM   726  C  CB  . ASN A 1 95  ? -23.35676 15.36996  -11.87201 1.000 28.45634 ? 95  ASN A CB  1 
ATOM   727  C  CG  . ASN A 1 95  ? -22.29783 14.53623  -11.16147 1.000 27.59477 ? 95  ASN A CG  1 
ATOM   728  O  OD1 . ASN A 1 95  ? -22.21916 14.50683  -9.92576  1.000 25.87413 ? 95  ASN A OD1 1 
ATOM   729  N  ND2 . ASN A 1 95  ? -21.47907 13.84356  -11.94706 1.000 24.70341 ? 95  ASN A ND2 1 
ATOM   730  N  N   . PRO A 1 96  ? -23.37972 17.09728  -8.78194  1.000 27.33863 ? 96  PRO A N   1 
ATOM   731  C  CA  . PRO A 1 96  ? -22.54763 18.03395  -8.00899  1.000 26.42241 ? 96  PRO A CA  1 
ATOM   732  C  C   . PRO A 1 96  ? -21.06092 17.81054  -8.21388  1.000 28.17269 ? 96  PRO A C   1 
ATOM   733  O  O   . PRO A 1 96  ? -20.26891 18.72374  -7.95450  1.000 26.15270 ? 96  PRO A O   1 
ATOM   734  C  CB  . PRO A 1 96  ? -22.95026 17.75810  -6.55257  1.000 30.01046 ? 96  PRO A CB  1 
ATOM   735  C  CG  . PRO A 1 96  ? -24.11269 16.81346  -6.60451  1.000 29.35482 ? 96  PRO A CG  1 
ATOM   736  C  CD  . PRO A 1 96  ? -24.04725 16.10642  -7.92361  1.000 26.05918 ? 96  PRO A CD  1 
ATOM   737  N  N   . LYS A 1 97  ? -20.66019 16.63520  -8.68573  1.000 26.16715 ? 97  LYS A N   1 
ATOM   738  C  CA  . LYS A 1 97  ? -19.25627 16.32830  -8.91847  1.000 28.29421 ? 97  LYS A CA  1 
ATOM   739  C  C   . LYS A 1 97  ? -18.80020 16.65369  -10.33626 1.000 28.52608 ? 97  LYS A C   1 
ATOM   740  O  O   . LYS A 1 97  ? -17.68166 16.28567  -10.70934 1.000 25.19391 ? 97  LYS A O   1 
ATOM   741  C  CB  . LYS A 1 97  ? -18.98912 14.85151  -8.61808  1.000 28.97952 ? 97  LYS A CB  1 
ATOM   742  C  CG  . LYS A 1 97  ? -19.26824 14.44722  -7.17343  1.000 29.48342 ? 97  LYS A CG  1 
ATOM   743  C  CD  . LYS A 1 97  ? -19.00805 12.96497  -6.98696  1.000 30.86001 ? 97  LYS A CD  1 
ATOM   744  C  CE  . LYS A 1 97  ? -19.39855 12.49460  -5.59924  1.000 45.01490 ? 97  LYS A CE  1 
ATOM   745  N  NZ  . LYS A 1 97  ? -19.14462 11.03507  -5.43561  1.000 51.10458 ? 97  LYS A NZ  1 
ATOM   746  N  N   . THR A 1 98  ? -19.63384 17.31886  -11.13167 1.000 28.23228 ? 98  THR A N   1 
ATOM   747  C  CA  . THR A 1 98  ? -19.26822 17.66342  -12.50081 1.000 26.04047 ? 98  THR A CA  1 
ATOM   748  C  C   . THR A 1 98  ? -17.99299 18.49403  -12.49708 1.000 26.33779 ? 98  THR A C   1 
ATOM   749  O  O   . THR A 1 98  ? -17.97300 19.57107  -11.88936 1.000 31.54539 ? 98  THR A O   1 
ATOM   750  C  CB  . THR A 1 98  ? -20.39516 18.44473  -13.19225 1.000 24.15059 ? 98  THR A CB  1 
ATOM   751  O  OG1 . THR A 1 98  ? -21.55205 17.61393  -13.33544 1.000 24.59681 ? 98  THR A OG1 1 
ATOM   752  C  CG2 . THR A 1 98  ? -19.94907 18.92347  -14.56007 1.000 26.50974 ? 98  THR A CG2 1 
ATOM   753  N  N   . PRO A 1 99  ? -16.92052 18.04695  -13.14105 1.000 27.51223 ? 99  PRO A N   1 
ATOM   754  C  CA  . PRO A 1 99  ? -15.69924 18.84926  -13.20083 1.000 25.60076 ? 99  PRO A CA  1 
ATOM   755  C  C   . PRO A 1 99  ? -15.77445 19.86425  -14.33546 1.000 25.59020 ? 99  PRO A C   1 
ATOM   756  O  O   . PRO A 1 99  ? -16.71669 19.88130  -15.12356 1.000 26.87794 ? 99  PRO A O   1 
ATOM   757  C  CB  . PRO A 1 99  ? -14.61318 17.80174  -13.48054 1.000 25.33614 ? 99  PRO A CB  1 
ATOM   758  C  CG  . PRO A 1 99  ? -15.32308 16.77608  -14.30015 1.000 25.05241 ? 99  PRO A CG  1 
ATOM   759  C  CD  . PRO A 1 99  ? -16.76162 16.74959  -13.82540 1.000 26.24294 ? 99  PRO A CD  1 
ATOM   760  N  N   . LYS A 1 100 ? -14.74954 20.71235  -14.40539 1.000 26.01229 ? 100 LYS A N   1 
ATOM   761  C  CA  . LYS A 1 100 ? -14.53326 21.47175  -15.62425 1.000 25.20091 ? 100 LYS A CA  1 
ATOM   762  C  C   . LYS A 1 100 ? -14.19738 20.49501  -16.74011 1.000 27.52188 ? 100 LYS A C   1 
ATOM   763  O  O   . LYS A 1 100 ? -13.35302 19.61106  -16.56939 1.000 29.07017 ? 100 LYS A O   1 
ATOM   764  C  CB  . LYS A 1 100 ? -13.40814 22.48839  -15.43841 1.000 24.85565 ? 100 LYS A CB  1 
ATOM   765  N  N   . TYR A 1 101 ? -14.88166 20.62430  -17.87247 1.000 28.49729 ? 101 TYR A N   1 
ATOM   766  C  CA  . TYR A 1 101 ? -14.71501 19.64944  -18.93703 1.000 26.33792 ? 101 TYR A CA  1 
ATOM   767  C  C   . TYR A 1 101 ? -14.92081 20.30952  -20.28987 1.000 29.63660 ? 101 TYR A C   1 
ATOM   768  O  O   . TYR A 1 101 ? -15.43687 21.42398  -20.39702 1.000 27.51355 ? 101 TYR A O   1 
ATOM   769  C  CB  . TYR A 1 101 ? -15.68060 18.46836  -18.77632 1.000 24.95052 ? 101 TYR A CB  1 
ATOM   770  C  CG  . TYR A 1 101 ? -17.12605 18.78982  -19.09317 1.000 25.15691 ? 101 TYR A CG  1 
ATOM   771  C  CD1 . TYR A 1 101 ? -17.97757 19.29902  -18.11757 1.000 28.16737 ? 101 TYR A CD1 1 
ATOM   772  C  CD2 . TYR A 1 101 ? -17.64384 18.57483  -20.36346 1.000 27.04187 ? 101 TYR A CD2 1 
ATOM   773  C  CE1 . TYR A 1 101 ? -19.30601 19.58799  -18.40312 1.000 26.45768 ? 101 TYR A CE1 1 
ATOM   774  C  CE2 . TYR A 1 101 ? -18.97532 18.86339  -20.66305 1.000 23.96265 ? 101 TYR A CE2 1 
ATOM   775  C  CZ  . TYR A 1 101 ? -19.79490 19.36909  -19.68426 1.000 29.93883 ? 101 TYR A CZ  1 
ATOM   776  O  OH  . TYR A 1 101 ? -21.10728 19.65063  -19.97577 1.000 29.74402 ? 101 TYR A OH  1 
ATOM   777  N  N   . LYS A 1 102 ? -14.50054 19.59096  -21.32759 1.000 26.73549 ? 102 LYS A N   1 
ATOM   778  C  CA  . LYS A 1 102 ? -14.87910 19.88577  -22.69934 1.000 24.41088 ? 102 LYS A CA  1 
ATOM   779  C  C   . LYS A 1 102 ? -14.83449 18.58679  -23.48444 1.000 26.25372 ? 102 LYS A C   1 
ATOM   780  O  O   . LYS A 1 102 ? -14.25305 17.59450  -23.03845 1.000 24.08874 ? 102 LYS A O   1 
ATOM   781  C  CB  . LYS A 1 102 ? -13.97332 20.94873  -23.33373 1.000 24.55872 ? 102 LYS A CB  1 
ATOM   782  C  CG  . LYS A 1 102 ? -12.49586 20.69459  -23.18837 1.000 31.71628 ? 102 LYS A CG  1 
ATOM   783  C  CD  . LYS A 1 102 ? -11.71590 21.88261  -23.73690 1.000 39.98283 ? 102 LYS A CD  1 
ATOM   784  C  CE  . LYS A 1 102 ? -10.25285 21.56056  -23.92229 1.000 36.53465 ? 102 LYS A CE  1 
ATOM   785  N  NZ  . LYS A 1 102 ? -9.52665  22.74125  -24.47543 1.000 47.26154 ? 102 LYS A NZ  1 
ATOM   786  N  N   . PHE A 1 103 ? -15.48139 18.60079  -24.64786 1.000 22.62937 ? 103 PHE A N   1 
ATOM   787  C  CA  . PHE A 1 103 ? -15.49293 17.47808  -25.57536 1.000 25.71110 ? 103 PHE A CA  1 
ATOM   788  C  C   . PHE A 1 103 ? -14.52764 17.77755  -26.71739 1.000 27.71416 ? 103 PHE A C   1 
ATOM   789  O  O   . PHE A 1 103 ? -14.62607 18.82946  -27.35721 1.000 26.69687 ? 103 PHE A O   1 
ATOM   790  C  CB  . PHE A 1 103 ? -16.89880 17.24150  -26.13573 1.000 22.42221 ? 103 PHE A CB  1 
ATOM   791  C  CG  . PHE A 1 103 ? -17.92726 16.84833  -25.10211 1.000 23.58461 ? 103 PHE A CG  1 
ATOM   792  C  CD1 . PHE A 1 103 ? -17.55052 16.36177  -23.86123 1.000 24.57013 ? 103 PHE A CD1 1 
ATOM   793  C  CD2 . PHE A 1 103 ? -19.28566 16.95017  -25.39015 1.000 24.40702 ? 103 PHE A CD2 1 
ATOM   794  C  CE1 . PHE A 1 103 ? -18.50894 15.99092  -22.92182 1.000 18.88192 ? 103 PHE A CE1 1 
ATOM   795  C  CE2 . PHE A 1 103 ? -20.24184 16.58413  -24.45874 1.000 22.82706 ? 103 PHE A CE2 1 
ATOM   796  C  CZ  . PHE A 1 103 ? -19.85346 16.10492  -23.22309 1.000 23.60647 ? 103 PHE A CZ  1 
ATOM   797  N  N   . VAL A 1 104 ? -13.58848 16.86890  -26.96435 1.000 24.32963 ? 104 VAL A N   1 
ATOM   798  C  CA  . VAL A 1 104 ? -12.60365 17.04690  -28.02261 1.000 24.93768 ? 104 VAL A CA  1 
ATOM   799  C  C   . VAL A 1 104 ? -12.59548 15.80115  -28.89724 1.000 24.08239 ? 104 VAL A C   1 
ATOM   800  O  O   . VAL A 1 104 ? -12.76530 14.68208  -28.40423 1.000 27.13369 ? 104 VAL A O   1 
ATOM   801  C  CB  . VAL A 1 104 ? -11.19217 17.33591  -27.46055 1.000 27.47789 ? 104 VAL A CB  1 
ATOM   802  C  CG1 . VAL A 1 104 ? -11.23088 18.50689  -26.48963 1.000 30.17867 ? 104 VAL A CG1 1 
ATOM   803  C  CG2 . VAL A 1 104 ? -10.62647 16.11684  -26.78005 1.000 28.26917 ? 104 VAL A CG2 1 
ATOM   804  N  N   . ARG A 1 105 ? -12.43530 15.99696  -30.19957 1.000 23.48577 ? 105 ARG A N   1 
ATOM   805  C  CA  . ARG A 1 105 ? -12.22825 14.89816  -31.12934 1.000 24.54385 ? 105 ARG A CA  1 
ATOM   806  C  C   . ARG A 1 105 ? -10.73937 14.80910  -31.41004 1.000 21.47307 ? 105 ARG A C   1 
ATOM   807  O  O   . ARG A 1 105 ? -10.11243 15.81017  -31.76988 1.000 26.71395 ? 105 ARG A O   1 
ATOM   808  C  CB  . ARG A 1 105 ? -13.00728 15.09584  -32.43209 1.000 24.54151 ? 105 ARG A CB  1 
ATOM   809  C  CG  . ARG A 1 105 ? -12.94319 13.87382  -33.36552 1.000 25.02557 ? 105 ARG A CG  1 
ATOM   810  C  CD  . ARG A 1 105 ? -13.84683 14.03443  -34.57324 1.000 23.29689 ? 105 ARG A CD  1 
ATOM   811  N  NE  . ARG A 1 105 ? -13.78660 12.86610  -35.44188 1.000 24.71386 ? 105 ARG A NE  1 
ATOM   812  C  CZ  . ARG A 1 105 ? -14.51639 11.77171  -35.27125 1.000 25.12273 ? 105 ARG A CZ  1 
ATOM   813  N  NH1 . ARG A 1 105 ? -15.38741 11.66877  -34.27705 1.000 19.67715 ? 105 ARG A NH1 1 
ATOM   814  N  NH2 . ARG A 1 105 ? -14.36121 10.75160  -36.10972 1.000 22.93389 ? 105 ARG A NH2 1 
ATOM   815  N  N   . ILE A 1 106 ? -10.17003 13.62966  -31.21907 1.000 20.86389 ? 106 ILE A N   1 
ATOM   816  C  CA  . ILE A 1 106 ? -8.73313  13.45265  -31.34202 1.000 26.95088 ? 106 ILE A CA  1 
ATOM   817  C  C   . ILE A 1 106 ? -8.41647  12.83211  -32.69393 1.000 26.51021 ? 106 ILE A C   1 
ATOM   818  O  O   . ILE A 1 106 ? -9.29094  12.33333  -33.39743 1.000 24.89421 ? 106 ILE A O   1 
ATOM   819  C  CB  . ILE A 1 106 ? -8.15372  12.60260  -30.18662 1.000 21.70973 ? 106 ILE A CB  1 
ATOM   820  C  CG1 . ILE A 1 106 ? -8.81048  11.21801  -30.16007 1.000 21.73181 ? 106 ILE A CG1 1 
ATOM   821  C  CG2 . ILE A 1 106 ? -8.32846  13.31636  -28.84911 1.000 24.36172 ? 106 ILE A CG2 1 
ATOM   822  C  CD1 . ILE A 1 106 ? -8.09872  10.22244  -29.26540 1.000 20.72422 ? 106 ILE A CD1 1 
ATOM   823  N  N   . GLN A 1 107 ? -7.14836  12.85414  -33.06301 1.000 23.51401 ? 107 GLN A N   1 
ATOM   824  C  CA  . GLN A 1 107 ? -6.63686  12.28794  -34.29817 1.000 26.65937 ? 107 GLN A CA  1 
ATOM   825  C  C   . GLN A 1 107 ? -5.83481  11.02465  -34.00585 1.000 23.75241 ? 107 GLN A C   1 
ATOM   826  O  O   . GLN A 1 107 ? -5.33503  10.84097  -32.88910 1.000 23.61631 ? 107 GLN A O   1 
ATOM   827  C  CB  . GLN A 1 107 ? -5.75113  13.30898  -35.03236 1.000 28.99939 ? 107 GLN A CB  1 
ATOM   828  C  CG  . GLN A 1 107 ? -6.49665  14.53669  -35.53139 1.000 31.91746 ? 107 GLN A CG  1 
ATOM   829  C  CD  . GLN A 1 107 ? -7.67092  14.17644  -36.42294 1.000 40.58748 ? 107 GLN A CD  1 
ATOM   830  O  OE1 . GLN A 1 107 ? -7.49415  13.63889  -37.52059 1.000 47.79285 ? 107 GLN A OE1 1 
ATOM   831  N  NE2 . GLN A 1 107 ? -8.88217  14.46492  -35.95370 1.000 38.61952 ? 107 GLN A NE2 1 
ATOM   832  N  N   . PRO A 1 108 ? -5.71706  10.11839  -34.97881 1.000 22.96374 ? 108 PRO A N   1 
ATOM   833  C  CA  . PRO A 1 108 ? -4.89127  8.91872   -34.78649 1.000 20.16917 ? 108 PRO A CA  1 
ATOM   834  C  C   . PRO A 1 108 ? -3.50148  9.27206   -34.27889 1.000 21.32041 ? 108 PRO A C   1 
ATOM   835  O  O   . PRO A 1 108 ? -2.89048  10.24662  -34.71880 1.000 21.59314 ? 108 PRO A O   1 
ATOM   836  C  CB  . PRO A 1 108 ? -4.82674  8.30522   -36.19182 1.000 25.26376 ? 108 PRO A CB  1 
ATOM   837  C  CG  . PRO A 1 108 ? -6.05440  8.76985   -36.86187 1.000 28.56599 ? 108 PRO A CG  1 
ATOM   838  C  CD  . PRO A 1 108 ? -6.34358  10.15074  -36.31382 1.000 24.78815 ? 108 PRO A CD  1 
ATOM   839  N  N   . GLY A 1 109 ? -3.00426  8.46364   -33.34265 1.000 20.00800 ? 109 GLY A N   1 
ATOM   840  C  CA  . GLY A 1 109 ? -1.73596  8.70642   -32.69656 1.000 23.27377 ? 109 GLY A CA  1 
ATOM   841  C  C   . GLY A 1 109 ? -1.84040  9.42403   -31.36888 1.000 20.85815 ? 109 GLY A C   1 
ATOM   842  O  O   . GLY A 1 109 ? -0.91956  9.32339   -30.55197 1.000 18.31638 ? 109 GLY A O   1 
ATOM   843  N  N   . GLN A 1 110 ? -2.93101  10.15212  -31.14172 1.000 18.96979 ? 110 GLN A N   1 
ATOM   844  C  CA  . GLN A 1 110 ? -3.14350  10.80133  -29.86058 1.000 21.88877 ? 110 GLN A CA  1 
ATOM   845  C  C   . GLN A 1 110 ? -3.38785  9.74873   -28.77816 1.000 20.52036 ? 110 GLN A C   1 
ATOM   846  O  O   . GLN A 1 110 ? -3.94642  8.67801   -29.03058 1.000 21.37662 ? 110 GLN A O   1 
ATOM   847  C  CB  . GLN A 1 110 ? -4.31902  11.78000  -29.96153 1.000 20.74510 ? 110 GLN A CB  1 
ATOM   848  C  CG  . GLN A 1 110 ? -4.59091  12.59917  -28.71934 1.000 22.76336 ? 110 GLN A CG  1 
ATOM   849  C  CD  . GLN A 1 110 ? -3.43186  13.49645  -28.32784 1.000 30.45341 ? 110 GLN A CD  1 
ATOM   850  O  OE1 . GLN A 1 110 ? -2.64135  13.15770  -27.44412 1.000 26.08635 ? 110 GLN A OE1 1 
ATOM   851  N  NE2 . GLN A 1 110 ? -3.33695  14.65764  -28.97201 1.000 28.81625 ? 110 GLN A NE2 1 
ATOM   852  N  N   . THR A 1 111 ? -2.93622  10.04915  -27.57031 1.000 18.71965 ? 111 THR A N   1 
ATOM   853  C  CA  . THR A 1 111 ? -3.09792  9.16729   -26.42252 1.000 21.16726 ? 111 THR A CA  1 
ATOM   854  C  C   . THR A 1 111 ? -4.15227  9.70922   -25.46768 1.000 21.03372 ? 111 THR A C   1 
ATOM   855  O  O   . THR A 1 111 ? -4.45881  10.90456  -25.45568 1.000 22.75617 ? 111 THR A O   1 
ATOM   856  C  CB  . THR A 1 111 ? -1.78083  9.00411   -25.65476 1.000 19.93575 ? 111 THR A CB  1 
ATOM   857  O  OG1 . THR A 1 111 ? -1.27745  10.30274  -25.30156 1.000 18.88010 ? 111 THR A OG1 1 
ATOM   858  C  CG2 . THR A 1 111 ? -0.76999  8.26481   -26.50712 1.000 20.69605 ? 111 THR A CG2 1 
ATOM   859  N  N   . PHE A 1 112 ? -4.68335  8.81262   -24.64024 1.000 19.41796 ? 112 PHE A N   1 
ATOM   860  C  CA  . PHE A 1 112 ? -5.65427  9.18749   -23.62201 1.000 20.34382 ? 112 PHE A CA  1 
ATOM   861  C  C   . PHE A 1 112 ? -5.78019  8.03537   -22.63620 1.000 19.75007 ? 112 PHE A C   1 
ATOM   862  O  O   . PHE A 1 112 ? -5.30143  6.92580   -22.88580 1.000 20.69802 ? 112 PHE A O   1 
ATOM   863  C  CB  . PHE A 1 112 ? -7.00955  9.54256   -24.24629 1.000 17.61093 ? 112 PHE A CB  1 
ATOM   864  C  CG  . PHE A 1 112 ? -7.61416  8.43575   -25.06535 1.000 20.12022 ? 112 PHE A CG  1 
ATOM   865  C  CD1 . PHE A 1 112 ? -7.24415  8.24815   -26.39763 1.000 21.18867 ? 112 PHE A CD1 1 
ATOM   866  C  CD2 . PHE A 1 112 ? -8.56398  7.59040   -24.51555 1.000 17.53810 ? 112 PHE A CD2 1 
ATOM   867  C  CE1 . PHE A 1 112 ? -7.82052  7.23815   -27.16632 1.000 21.24165 ? 112 PHE A CE1 1 
ATOM   868  C  CE2 . PHE A 1 112 ? -9.14037  6.57623   -25.28000 1.000 19.04718 ? 112 PHE A CE2 1 
ATOM   869  C  CZ  . PHE A 1 112 ? -8.76512  6.40151   -26.60783 1.000 20.00558 ? 112 PHE A CZ  1 
ATOM   870  N  N   . SER A 1 113 ? -6.43497  8.31513   -21.51300 1.000 15.51281 ? 113 SER A N   1 
ATOM   871  C  CA  . SER A 1 113 ? -6.68609  7.32721   -20.47257 1.000 18.40336 ? 113 SER A CA  1 
ATOM   872  C  C   . SER A 1 113 ? -8.10574  6.80923   -20.59313 1.000 18.24406 ? 113 SER A C   1 
ATOM   873  O  O   . SER A 1 113 ? -9.01742  7.53984   -20.99327 1.000 18.84188 ? 113 SER A O   1 
ATOM   874  C  CB  . SER A 1 113 ? -6.47538  7.91576   -19.07184 1.000 20.42193 ? 113 SER A CB  1 
ATOM   875  O  OG  . SER A 1 113 ? -5.16306  8.44080   -18.92652 1.000 19.33395 ? 113 SER A OG  1 
ATOM   876  N  N   . VAL A 1 114 ? -8.29428  5.54389   -20.23572 1.000 16.47958 ? 114 VAL A N   1 
ATOM   877  C  CA  . VAL A 1 114 ? -9.61799  4.93295   -20.21474 1.000 16.81485 ? 114 VAL A CA  1 
ATOM   878  C  C   . VAL A 1 114 ? -9.95551  4.54469   -18.78097 1.000 19.14653 ? 114 VAL A C   1 
ATOM   879  O  O   . VAL A 1 114 ? -9.14232  3.91343   -18.09927 1.000 16.87265 ? 114 VAL A O   1 
ATOM   880  C  CB  . VAL A 1 114 ? -9.68542  3.71057   -21.14534 1.000 21.34076 ? 114 VAL A CB  1 
ATOM   881  C  CG1 . VAL A 1 114 ? -11.03328 2.98763   -20.97723 1.000 17.61086 ? 114 VAL A CG1 1 
ATOM   882  C  CG2 . VAL A 1 114 ? -9.44075  4.13670   -22.59597 1.000 19.37369 ? 114 VAL A CG2 1 
ATOM   883  N  N   . LEU A 1 115 ? -11.15640 4.91897   -18.32702 1.000 16.01591 ? 115 LEU A N   1 
ATOM   884  C  CA  . LEU A 1 115 ? -11.70394 4.45112   -17.05219 1.000 17.29134 ? 115 LEU A CA  1 
ATOM   885  C  C   . LEU A 1 115 ? -12.71148 3.35540   -17.38865 1.000 18.12080 ? 115 LEU A C   1 
ATOM   886  O  O   . LEU A 1 115 ? -13.87369 3.62416   -17.69180 1.000 16.97429 ? 115 LEU A O   1 
ATOM   887  C  CB  . LEU A 1 115 ? -12.34859 5.58741   -16.25729 1.000 13.72208 ? 115 LEU A CB  1 
ATOM   888  C  CG  . LEU A 1 115 ? -12.94277 5.17621   -14.90797 1.000 18.76321 ? 115 LEU A CG  1 
ATOM   889  C  CD1 . LEU A 1 115 ? -11.83032 4.64477   -14.01813 1.000 17.90061 ? 115 LEU A CD1 1 
ATOM   890  C  CD2 . LEU A 1 115 ? -13.68181 6.33266   -14.21497 1.000 17.90529 ? 115 LEU A CD2 1 
ATOM   891  N  N   . ALA A 1 116 ? -12.25511 2.10864   -17.35521 1.000 16.42244 ? 116 ALA A N   1 
ATOM   892  C  CA  . ALA A 1 116 ? -13.14130 0.99336   -17.66058 1.000 19.21950 ? 116 ALA A CA  1 
ATOM   893  C  C   . ALA A 1 116 ? -14.15407 0.80590   -16.53085 1.000 18.57464 ? 116 ALA A C   1 
ATOM   894  O  O   . ALA A 1 116 ? -13.78502 0.75178   -15.35210 1.000 19.69900 ? 116 ALA A O   1 
ATOM   895  C  CB  . ALA A 1 116 ? -12.33289 -0.28594  -17.88786 1.000 18.47507 ? 116 ALA A CB  1 
ATOM   896  N  N   . CYS A 1 117 ? -15.43485 0.70946   -16.89318 1.000 17.82897 ? 117 CYS A N   1 
ATOM   897  C  CA  . CYS A 1 117 ? -16.51482 0.63386   -15.91741 1.000 18.94041 ? 117 CYS A CA  1 
ATOM   898  C  C   . CYS A 1 117 ? -17.51631 -0.44299  -16.30795 1.000 19.30343 ? 117 CYS A C   1 
ATOM   899  O  O   . CYS A 1 117 ? -17.70289 -0.75117  -17.49163 1.000 19.02754 ? 117 CYS A O   1 
ATOM   900  C  CB  . CYS A 1 117 ? -17.26858 1.95932   -15.78927 1.000 20.42272 ? 117 CYS A CB  1 
ATOM   901  S  SG  . CYS A 1 117 ? -16.24633 3.32486   -15.25018 1.000 22.06004 ? 117 CYS A SG  1 
ATOM   902  N  N   . TYR A 1 118 ? -18.15567 -1.00441  -15.28479 1.000 19.28281 ? 118 TYR A N   1 
ATOM   903  C  CA  . TYR A 1 118 ? -19.23675 -1.96982  -15.42204 1.000 20.95390 ? 118 TYR A CA  1 
ATOM   904  C  C   . TYR A 1 118 ? -20.30876 -1.59310  -14.41680 1.000 22.87327 ? 118 TYR A C   1 
ATOM   905  O  O   . TYR A 1 118 ? -20.00109 -1.32613  -13.24943 1.000 22.23364 ? 118 TYR A O   1 
ATOM   906  C  CB  . TYR A 1 118 ? -18.74574 -3.40593  -15.18946 1.000 21.47466 ? 118 TYR A CB  1 
ATOM   907  C  CG  . TYR A 1 118 ? -17.63056 -3.75306  -16.14661 1.000 23.04608 ? 118 TYR A CG  1 
ATOM   908  C  CD1 . TYR A 1 118 ? -16.31204 -3.46407  -15.83290 1.000 22.09950 ? 118 TYR A CD1 1 
ATOM   909  C  CD2 . TYR A 1 118 ? -17.90658 -4.29887  -17.39407 1.000 23.73371 ? 118 TYR A CD2 1 
ATOM   910  C  CE1 . TYR A 1 118 ? -15.29704 -3.73502  -16.72056 1.000 23.54533 ? 118 TYR A CE1 1 
ATOM   911  C  CE2 . TYR A 1 118 ? -16.90092 -4.57975  -18.28318 1.000 21.08846 ? 118 TYR A CE2 1 
ATOM   912  C  CZ  . TYR A 1 118 ? -15.59965 -4.29242  -17.94222 1.000 22.26633 ? 118 TYR A CZ  1 
ATOM   913  O  OH  . TYR A 1 118 ? -14.60415 -4.56524  -18.83404 1.000 19.45461 ? 118 TYR A OH  1 
ATOM   914  N  N   . ASN A 1 119 ? -21.55679 -1.53882  -14.87586 1.000 21.96937 ? 119 ASN A N   1 
ATOM   915  C  CA  . ASN A 1 119 ? -22.67547 -1.22130  -13.99320 1.000 24.83797 ? 119 ASN A CA  1 
ATOM   916  C  C   . ASN A 1 119 ? -22.46513 0.10528   -13.27462 1.000 23.51720 ? 119 ASN A C   1 
ATOM   917  O  O   . ASN A 1 119 ? -22.85018 0.25973   -12.11631 1.000 26.25191 ? 119 ASN A O   1 
ATOM   918  C  CB  . ASN A 1 119 ? -22.90754 -2.34291  -12.97596 1.000 27.64789 ? 119 ASN A CB  1 
ATOM   919  C  CG  . ASN A 1 119 ? -23.28792 -3.66061  -13.63994 1.000 30.97564 ? 119 ASN A CG  1 
ATOM   920  O  OD1 . ASN A 1 119 ? -24.22588 -3.71683  -14.43343 1.000 34.19819 ? 119 ASN A OD1 1 
ATOM   921  N  ND2 . ASN A 1 119 ? -22.55627 -4.72119  -13.32270 1.000 34.97502 ? 119 ASN A ND2 1 
ATOM   922  N  N   . GLY A 1 120 ? -21.83379 1.06564   -13.94821 1.000 21.95871 ? 120 GLY A N   1 
ATOM   923  C  CA  . GLY A 1 120 ? -21.62327 2.38348   -13.38701 1.000 20.38414 ? 120 GLY A CA  1 
ATOM   924  C  C   . GLY A 1 120 ? -20.49247 2.49608   -12.38614 1.000 25.04400 ? 120 GLY A C   1 
ATOM   925  O  O   . GLY A 1 120 ? -20.28994 3.58427   -11.82719 1.000 24.45646 ? 120 GLY A O   1 
ATOM   926  N  N   . SER A 1 121 ? -19.74825 1.41683   -12.14382 1.000 21.78077 ? 121 SER A N   1 
ATOM   927  C  CA  A SER A 1 121 ? -18.67009 1.41098   -11.17404 0.500 25.40111 ? 121 SER A CA  1 
ATOM   928  C  CA  B SER A 1 121 ? -18.66726 1.40744   -11.17250 0.500 25.08247 ? 121 SER A CA  1 
ATOM   929  C  C   . SER A 1 121 ? -17.33888 1.19771   -11.87794 1.000 23.84590 ? 121 SER A C   1 
ATOM   930  O  O   . SER A 1 121 ? -17.24234 0.32861   -12.75424 1.000 22.06605 ? 121 SER A O   1 
ATOM   931  C  CB  A SER A 1 121 ? -18.89410 0.31067   -10.12963 0.500 26.16948 ? 121 SER A CB  1 
ATOM   932  C  CB  B SER A 1 121 ? -18.89318 0.29810   -10.14133 0.500 26.67664 ? 121 SER A CB  1 
ATOM   933  O  OG  A SER A 1 121 ? -17.94047 0.40885   -9.08305  0.500 33.10526 ? 121 SER A OG  1 
ATOM   934  O  OG  B SER A 1 121 ? -20.10070 0.51220   -9.42723  0.500 30.61701 ? 121 SER A OG  1 
ATOM   935  N  N   . PRO A 1 122 ? -16.30523 1.95497   -11.52703 1.000 23.77185 ? 122 PRO A N   1 
ATOM   936  C  CA  . PRO A 1 122 ? -15.02432 1.82917   -12.23482 1.000 23.15356 ? 122 PRO A CA  1 
ATOM   937  C  C   . PRO A 1 122 ? -14.29419 0.55021   -11.86744 1.000 25.12357 ? 122 PRO A C   1 
ATOM   938  O  O   . PRO A 1 122 ? -14.26276 0.13211   -10.70657 1.000 31.15639 ? 122 PRO A O   1 
ATOM   939  C  CB  . PRO A 1 122 ? -14.24420 3.06230   -11.76837 1.000 25.02824 ? 122 PRO A CB  1 
ATOM   940  C  CG  . PRO A 1 122 ? -14.77473 3.31550   -10.38706 1.000 33.25443 ? 122 PRO A CG  1 
ATOM   941  C  CD  . PRO A 1 122 ? -16.26027 2.99312   -10.48305 1.000 28.09017 ? 122 PRO A CD  1 
ATOM   942  N  N   . SER A 1 123 ? -13.71117 -0.07909  -12.87656 1.000 23.91336 ? 123 SER A N   1 
ATOM   943  C  CA  . SER A 1 123 ? -12.89316 -1.26391  -12.66526 1.000 22.80057 ? 123 SER A CA  1 
ATOM   944  C  C   . SER A 1 123 ? -11.40343 -0.94451  -12.63341 1.000 25.15313 ? 123 SER A C   1 
ATOM   945  O  O   . SER A 1 123 ? -10.67303 -1.49433  -11.80058 1.000 22.16306 ? 123 SER A O   1 
ATOM   946  C  CB  . SER A 1 123 ? -13.18796 -2.30052  -13.75528 1.000 22.84850 ? 123 SER A CB  1 
ATOM   947  O  OG  . SER A 1 123 ? -12.15949 -3.27512  -13.86768 1.000 39.57256 ? 123 SER A OG  1 
ATOM   948  N  N   . GLY A 1 124 ? -10.93835 -0.06991  -13.51709 1.000 19.95383 ? 124 GLY A N   1 
ATOM   949  C  CA  . GLY A 1 124 ? -9.51622  0.22553   -13.60659 1.000 20.05998 ? 124 GLY A CA  1 
ATOM   950  C  C   . GLY A 1 124 ? -9.27794  1.31077   -14.63312 1.000 19.60441 ? 124 GLY A C   1 
ATOM   951  O  O   . GLY A 1 124 ? -10.16783 1.67994   -15.40504 1.000 18.54010 ? 124 GLY A O   1 
ATOM   952  N  N   . VAL A 1 125 ? -8.05692  1.82786   -14.62813 1.000 17.56515 ? 125 VAL A N   1 
ATOM   953  C  CA  . VAL A 1 125 ? -7.68585  2.91704   -15.51287 1.000 16.39119 ? 125 VAL A CA  1 
ATOM   954  C  C   . VAL A 1 125 ? -6.44193  2.50034   -16.28057 1.000 19.25454 ? 125 VAL A C   1 
ATOM   955  O  O   . VAL A 1 125 ? -5.54821  1.85170   -15.72996 1.000 18.38051 ? 125 VAL A O   1 
ATOM   956  C  CB  . VAL A 1 125 ? -7.47866  4.23978   -14.73557 1.000 19.41343 ? 125 VAL A CB  1 
ATOM   957  C  CG1 . VAL A 1 125 ? -6.35153  4.12464   -13.73604 1.000 21.63042 ? 125 VAL A CG1 1 
ATOM   958  C  CG2 . VAL A 1 125 ? -7.25606  5.41159   -15.68317 1.000 21.18181 ? 125 VAL A CG2 1 
ATOM   959  N  N   . TYR A 1 126 ? -6.40396  2.82671   -17.56743 1.000 17.82704 ? 126 TYR A N   1 
ATOM   960  C  CA  . TYR A 1 126 ? -5.20891  2.53575   -18.34406 1.000 22.75360 ? 126 TYR A CA  1 
ATOM   961  C  C   . TYR A 1 126 ? -5.06488  3.54797   -19.46847 1.000 21.00036 ? 126 TYR A C   1 
ATOM   962  O  O   . TYR A 1 126 ? -6.02148  4.21586   -19.87404 1.000 19.86348 ? 126 TYR A O   1 
ATOM   963  C  CB  . TYR A 1 126 ? -5.22076  1.10493   -18.89767 1.000 18.94782 ? 126 TYR A CB  1 
ATOM   964  C  CG  . TYR A 1 126 ? -6.43195  0.76394   -19.72974 1.000 23.29732 ? 126 TYR A CG  1 
ATOM   965  C  CD1 . TYR A 1 126 ? -6.45668  1.02661   -21.09005 1.000 20.01521 ? 126 TYR A CD1 1 
ATOM   966  C  CD2 . TYR A 1 126 ? -7.54655  0.17414   -19.15275 1.000 23.09694 ? 126 TYR A CD2 1 
ATOM   967  C  CE1 . TYR A 1 126 ? -7.55874  0.71013   -21.85396 1.000 24.45772 ? 126 TYR A CE1 1 
ATOM   968  C  CE2 . TYR A 1 126 ? -8.65258  -0.14499  -19.90752 1.000 19.85239 ? 126 TYR A CE2 1 
ATOM   969  C  CZ  . TYR A 1 126 ? -8.64952  0.12535   -21.26014 1.000 20.59243 ? 126 TYR A CZ  1 
ATOM   970  O  OH  . TYR A 1 126 ? -9.74622  -0.18506  -22.02594 1.000 27.44041 ? 126 TYR A OH  1 
ATOM   971  N  N   . GLN A 1 127 ? -3.84213  3.64671   -19.95617 1.000 20.41314 ? 127 GLN A N   1 
ATOM   972  C  CA  . GLN A 1 127 ? -3.45560  4.58053   -20.99477 1.000 21.39795 ? 127 GLN A CA  1 
ATOM   973  C  C   . GLN A 1 127 ? -3.41864  3.83086   -22.31985 1.000 23.92841 ? 127 GLN A C   1 
ATOM   974  O  O   . GLN A 1 127 ? -3.02889  2.65888   -22.36446 1.000 24.50778 ? 127 GLN A O   1 
ATOM   975  C  CB  . GLN A 1 127 ? -2.08531  5.18493   -20.66237 1.000 22.78896 ? 127 GLN A CB  1 
ATOM   976  C  CG  . GLN A 1 127 ? -1.59575  6.23414   -21.60240 1.000 25.21356 ? 127 GLN A CG  1 
ATOM   977  C  CD  . GLN A 1 127 ? -2.27854  7.57138   -21.39969 1.000 22.86688 ? 127 GLN A CD  1 
ATOM   978  O  OE1 . GLN A 1 127 ? -3.24982  7.68884   -20.64426 1.000 23.05375 ? 127 GLN A OE1 1 
ATOM   979  N  NE2 . GLN A 1 127 ? -1.76830  8.59405   -22.07580 1.000 24.44868 ? 127 GLN A NE2 1 
ATOM   980  N  N   . CYS A 1 128 ? -3.87834  4.48369   -23.38784 1.000 22.84416 ? 128 CYS A N   1 
ATOM   981  C  CA  . CYS A 1 128 ? -3.79183  3.89724   -24.72284 1.000 25.02200 ? 128 CYS A CA  1 
ATOM   982  C  C   . CYS A 1 128 ? -3.79578  5.00892   -25.76506 1.000 23.91925 ? 128 CYS A C   1 
ATOM   983  O  O   . CYS A 1 128 ? -3.79070  6.19822   -25.44118 1.000 23.13636 ? 128 CYS A O   1 
ATOM   984  C  CB  . CYS A 1 128 ? -4.92027  2.89673   -24.97004 1.000 22.36812 ? 128 CYS A CB  1 
ATOM   985  S  SG  . CYS A 1 128 ? -6.52774  3.64534   -24.99526 1.000 30.09713 ? 128 CYS A SG  1 
ATOM   986  N  N   . ALA A 1 129 ? -3.78069  4.61072   -27.03307 1.000 28.17765 ? 129 ALA A N   1 
ATOM   987  C  CA  . ALA A 1 129 ? -3.69353  5.55172   -28.13685 1.000 20.60085 ? 129 ALA A CA  1 
ATOM   988  C  C   . ALA A 1 129 ? -4.70632  5.19610   -29.21120 1.000 22.83891 ? 129 ALA A C   1 
ATOM   989  O  O   . ALA A 1 129 ? -5.08122  4.03261   -29.39173 1.000 23.84302 ? 129 ALA A O   1 
ATOM   990  C  CB  . ALA A 1 129 ? -2.28946  5.57237   -28.75343 1.000 22.14538 ? 129 ALA A CB  1 
ATOM   991  N  N   . MET A 1 130 ? -5.15348  6.20931   -29.92881 1.000 19.88846 ? 130 MET A N   1 
ATOM   992  C  CA  A MET A 1 130 ? -5.96834  5.97620   -31.11203 0.500 22.30543 ? 130 MET A CA  1 
ATOM   993  C  CA  B MET A 1 130 ? -5.96664  5.95011   -31.10404 0.500 22.31679 ? 130 MET A CA  1 
ATOM   994  C  C   . MET A 1 130 ? -5.07877  5.44905   -32.23536 1.000 23.37478 ? 130 MET A C   1 
ATOM   995  O  O   . MET A 1 130 ? -4.17844  6.16055   -32.70065 1.000 21.87392 ? 130 MET A O   1 
ATOM   996  C  CB  A MET A 1 130 ? -6.66450  7.27020   -31.52627 0.500 21.33928 ? 130 MET A CB  1 
ATOM   997  C  CB  B MET A 1 130 ? -6.72096  7.19681   -31.53327 0.500 20.56657 ? 130 MET A CB  1 
ATOM   998  C  CG  A MET A 1 130 ? -7.51398  7.15121   -32.77776 0.500 21.40751 ? 130 MET A CG  1 
ATOM   999  C  CG  B MET A 1 130 ? -7.39232  6.98667   -32.86361 0.500 21.38199 ? 130 MET A CG  1 
ATOM   1000 S  SD  A MET A 1 130 ? -8.96230  6.12278   -32.50288 0.500 16.18724 ? 130 MET A SD  1 
ATOM   1001 S  SD  B MET A 1 130 ? -8.89217  7.94363   -32.99552 0.500 23.43624 ? 130 MET A SD  1 
ATOM   1002 C  CE  A MET A 1 130 ? -9.77731  7.05041   -31.20713 0.500 21.88606 ? 130 MET A CE  1 
ATOM   1003 C  CE  B MET A 1 130 ? -9.61511  7.67320   -31.37661 0.500 22.12816 ? 130 MET A CE  1 
ATOM   1004 N  N   . ARG A 1 131 ? -5.31366  4.20741   -32.65812 1.000 20.91207 ? 131 ARG A N   1 
ATOM   1005 C  CA  . ARG A 1 131 ? -4.50819  3.62302   -33.71359 1.000 20.95133 ? 131 ARG A CA  1 
ATOM   1006 C  C   . ARG A 1 131 ? -4.75770  4.36011   -35.02928 1.000 19.13616 ? 131 ARG A C   1 
ATOM   1007 O  O   . ARG A 1 131 ? -5.76727  5.05368   -35.17963 1.000 19.93609 ? 131 ARG A O   1 
ATOM   1008 C  CB  . ARG A 1 131 ? -4.82323  2.13567   -33.86805 1.000 20.49635 ? 131 ARG A CB  1 
ATOM   1009 C  CG  . ARG A 1 131 ? -4.71107  1.31445   -32.58732 1.000 21.50573 ? 131 ARG A CG  1 
ATOM   1010 C  CD  . ARG A 1 131 ? -3.33172  1.41032   -31.93424 1.000 19.21179 ? 131 ARG A CD  1 
ATOM   1011 N  NE  . ARG A 1 131 ? -2.23234  1.22235   -32.87813 1.000 19.52347 ? 131 ARG A NE  1 
ATOM   1012 C  CZ  . ARG A 1 131 ? -0.95726  1.46834   -32.59238 1.000 22.02829 ? 131 ARG A CZ  1 
ATOM   1013 N  NH1 . ARG A 1 131 ? -0.57841  1.85690   -31.38330 1.000 18.30299 ? 131 ARG A NH1 1 
ATOM   1014 N  NH2 . ARG A 1 131 ? -0.03885  1.32672   -33.54178 1.000 19.65871 ? 131 ARG A NH2 1 
ATOM   1015 N  N   . PRO A 1 132 ? -3.83253  4.25443   -35.99034 1.000 18.09290 ? 132 PRO A N   1 
ATOM   1016 C  CA  . PRO A 1 132 ? -4.08165  4.86391   -37.31301 1.000 20.42626 ? 132 PRO A CA  1 
ATOM   1017 C  C   . PRO A 1 132 ? -5.31273  4.31911   -38.02356 1.000 19.47257 ? 132 PRO A C   1 
ATOM   1018 O  O   . PRO A 1 132 ? -5.85367  5.00917   -38.89068 1.000 22.52658 ? 132 PRO A O   1 
ATOM   1019 C  CB  . PRO A 1 132 ? -2.79994  4.54817   -38.10116 1.000 20.04985 ? 132 PRO A CB  1 
ATOM   1020 C  CG  . PRO A 1 132 ? -1.73948  4.36424   -37.03254 1.000 22.04787 ? 132 PRO A CG  1 
ATOM   1021 C  CD  . PRO A 1 132 ? -2.46179  3.72668   -35.86804 1.000 18.12888 ? 132 PRO A CD  1 
ATOM   1022 N  N   . ASN A 1 133 ? -5.75583  3.10193   -37.71695 1.000 20.02397 ? 133 ASN A N   1 
ATOM   1023 C  CA  . ASN A 1 133 ? -6.98093  2.55934   -38.29346 1.000 21.11997 ? 133 ASN A CA  1 
ATOM   1024 C  C   . ASN A 1 133 ? -8.21716  2.89022   -37.45730 1.000 27.02948 ? 133 ASN A C   1 
ATOM   1025 O  O   . ASN A 1 133 ? -9.25635  2.23933   -37.62041 1.000 23.49013 ? 133 ASN A O   1 
ATOM   1026 C  CB  . ASN A 1 133 ? -6.86715  1.03792   -38.48678 1.000 19.75513 ? 133 ASN A CB  1 
ATOM   1027 C  CG  . ASN A 1 133 ? -6.77529  0.26648   -37.16961 1.000 23.88177 ? 133 ASN A CG  1 
ATOM   1028 O  OD1 . ASN A 1 133 ? -6.86638  0.83316   -36.07515 1.000 21.36000 ? 133 ASN A OD1 1 
ATOM   1029 N  ND2 . ASN A 1 133 ? -6.59698  -1.04232  -37.27828 1.000 25.34674 ? 133 ASN A ND2 1 
ATOM   1030 N  N   . PHE A 1 134 ? -8.10807  3.86132   -36.54802 1.000 23.93448 ? 134 PHE A N   1 
ATOM   1031 C  CA  . PHE A 1 134 ? -9.22110  4.42682   -35.79362 1.000 22.06535 ? 134 PHE A CA  1 
ATOM   1032 C  C   . PHE A 1 134 ? -9.85157  3.44086   -34.82246 1.000 22.86512 ? 134 PHE A C   1 
ATOM   1033 O  O   . PHE A 1 134 ? -10.98894 3.64318   -34.39335 1.000 25.46403 ? 134 PHE A O   1 
ATOM   1034 C  CB  . PHE A 1 134 ? -10.29730 4.99273   -36.72363 1.000 22.76978 ? 134 PHE A CB  1 
ATOM   1035 C  CG  . PHE A 1 134 ? -9.84968  6.17694   -37.49977 1.000 22.91764 ? 134 PHE A CG  1 
ATOM   1036 C  CD1 . PHE A 1 134 ? -9.81144  7.42469   -36.90954 1.000 24.81631 ? 134 PHE A CD1 1 
ATOM   1037 C  CD2 . PHE A 1 134 ? -9.45711  6.04657   -38.81635 1.000 24.03313 ? 134 PHE A CD2 1 
ATOM   1038 C  CE1 . PHE A 1 134 ? -9.38943  8.52561   -37.62162 1.000 27.66636 ? 134 PHE A CE1 1 
ATOM   1039 C  CE2 . PHE A 1 134 ? -9.02842  7.14104   -39.53454 1.000 25.16353 ? 134 PHE A CE2 1 
ATOM   1040 C  CZ  . PHE A 1 134 ? -8.99427  8.37973   -38.93897 1.000 25.35764 ? 134 PHE A CZ  1 
ATOM   1041 N  N   . THR A 1 135 ? -9.15678  2.36296   -34.48818 1.000 20.83273 ? 135 THR A N   1 
ATOM   1042 C  CA  . THR A 1 135 ? -9.53056  1.51749   -33.37300 1.000 20.07401 ? 135 THR A CA  1 
ATOM   1043 C  C   . THR A 1 135 ? -8.62946  1.83881   -32.19159 1.000 20.88218 ? 135 THR A C   1 
ATOM   1044 O  O   . THR A 1 135 ? -7.63870  2.55594   -32.31396 1.000 22.27371 ? 135 THR A O   1 
ATOM   1045 C  CB  . THR A 1 135 ? -9.40858  0.04000   -33.74106 1.000 24.76032 ? 135 THR A CB  1 
ATOM   1046 O  OG1 . THR A 1 135 ? -8.02255  -0.30519  -33.85450 1.000 22.45771 ? 135 THR A OG1 1 
ATOM   1047 C  CG2 . THR A 1 135 ? -10.10872 -0.24041  -35.05551 1.000 23.00584 ? 135 THR A CG2 1 
ATOM   1048 N  N   . ILE A 1 136 ? -8.99183  1.31591   -31.03167 1.000 19.85139 ? 136 ILE A N   1 
ATOM   1049 C  CA  . ILE A 1 136 ? -8.11476  1.36845   -29.87381 1.000 20.28268 ? 136 ILE A CA  1 
ATOM   1050 C  C   . ILE A 1 136 ? -7.93127  -0.05615  -29.38089 1.000 21.23357 ? 136 ILE A C   1 
ATOM   1051 O  O   . ILE A 1 136 ? -8.82297  -0.89940  -29.51200 1.000 21.63934 ? 136 ILE A O   1 
ATOM   1052 C  CB  . ILE A 1 136 ? -8.64236  2.30012   -28.74840 1.000 26.36627 ? 136 ILE A CB  1 
ATOM   1053 C  CG1 . ILE A 1 136 ? -9.68825  1.60165   -27.88596 1.000 21.10933 ? 136 ILE A CG1 1 
ATOM   1054 C  CG2 . ILE A 1 136 ? -9.21535  3.60192   -29.33983 1.000 21.16842 ? 136 ILE A CG2 1 
ATOM   1055 C  CD1 . ILE A 1 136 ? -10.25625 2.48498   -26.81247 1.000 27.56136 ? 136 ILE A CD1 1 
ATOM   1056 N  N   . LYS A 1 137 ? -6.73468  -0.33934  -28.87017 1.000 20.44288 ? 137 LYS A N   1 
ATOM   1057 C  CA  . LYS A 1 137 ? -6.42234  -1.65520  -28.31681 1.000 20.92421 ? 137 LYS A CA  1 
ATOM   1058 C  C   . LYS A 1 137 ? -6.67705  -1.57444  -26.81832 1.000 24.28016 ? 137 LYS A C   1 
ATOM   1059 O  O   . LYS A 1 137 ? -5.78579  -1.31156  -26.00833 1.000 25.30656 ? 137 LYS A O   1 
ATOM   1060 C  CB  . LYS A 1 137 ? -4.98742  -2.04842  -28.64490 1.000 25.63535 ? 137 LYS A CB  1 
ATOM   1061 C  CG  . LYS A 1 137 ? -4.74264  -2.23641  -30.13058 1.000 28.50262 ? 137 LYS A CG  1 
ATOM   1062 C  CD  . LYS A 1 137 ? -3.26928  -2.48005  -30.42035 1.000 26.46759 ? 137 LYS A CD  1 
ATOM   1063 C  CE  . LYS A 1 137 ? -3.10753  -3.34623  -31.65562 1.000 39.84245 ? 137 LYS A CE  1 
ATOM   1064 N  NZ  . LYS A 1 137 ? -1.69828  -3.82845  -31.77661 1.000 48.43139 ? 137 LYS A NZ  1 
ATOM   1065 N  N   . GLY A 1 138 ? -7.94196  -1.76991  -26.44902 1.000 20.20655 ? 138 GLY A N   1 
ATOM   1066 C  CA  . GLY A 1 138 ? -8.37642  -1.59214  -25.08558 1.000 21.02732 ? 138 GLY A CA  1 
ATOM   1067 C  C   . GLY A 1 138 ? -8.46462  -2.90859  -24.34333 1.000 22.57010 ? 138 GLY A C   1 
ATOM   1068 O  O   . GLY A 1 138 ? -8.07300  -3.97075  -24.83366 1.000 22.11952 ? 138 GLY A O   1 
ATOM   1069 N  N   . SER A 1 139 ? -8.99516  -2.82207  -23.13148 1.000 18.91717 ? 139 SER A N   1 
ATOM   1070 C  CA  . SER A 1 139 ? -9.32258  -3.99296  -22.33553 1.000 21.29518 ? 139 SER A CA  1 
ATOM   1071 C  C   . SER A 1 139 ? -10.74390 -3.79672  -21.83743 1.000 19.92885 ? 139 SER A C   1 
ATOM   1072 O  O   . SER A 1 139 ? -10.97818 -3.02223  -20.90179 1.000 20.97846 ? 139 SER A O   1 
ATOM   1073 C  CB  . SER A 1 139 ? -8.35324  -4.18302  -21.17409 1.000 19.10949 ? 139 SER A CB  1 
ATOM   1074 O  OG  . SER A 1 139 ? -8.77406  -5.27686  -20.37993 1.000 22.73868 ? 139 SER A OG  1 
ATOM   1075 N  N   . PHE A 1 140 ? -11.67846 -4.52042  -22.44176 1.000 20.99464 ? 140 PHE A N   1 
ATOM   1076 C  CA  . PHE A 1 140 ? -13.10103 -4.25223  -22.30177 1.000 21.04783 ? 140 PHE A CA  1 
ATOM   1077 C  C   . PHE A 1 140 ? -13.85851 -5.57096  -22.28693 1.000 23.75446 ? 140 PHE A C   1 
ATOM   1078 O  O   . PHE A 1 140 ? -13.58370 -6.45509  -23.09923 1.000 25.14713 ? 140 PHE A O   1 
ATOM   1079 C  CB  . PHE A 1 140 ? -13.61784 -3.39680  -23.46944 1.000 18.98418 ? 140 PHE A CB  1 
ATOM   1080 C  CG  . PHE A 1 140 ? -13.26025 -1.93766  -23.38281 1.000 21.18195 ? 140 PHE A CG  1 
ATOM   1081 C  CD1 . PHE A 1 140 ? -13.45935 -1.22011  -22.20665 1.000 22.12779 ? 140 PHE A CD1 1 
ATOM   1082 C  CD2 . PHE A 1 140 ? -12.73815 -1.28023  -24.48271 1.000 20.02852 ? 140 PHE A CD2 1 
ATOM   1083 C  CE1 . PHE A 1 140 ? -13.15161 0.13331   -22.14028 1.000 20.62857 ? 140 PHE A CE1 1 
ATOM   1084 C  CE2 . PHE A 1 140 ? -12.43021 0.07455   -24.42338 1.000 22.36267 ? 140 PHE A CE2 1 
ATOM   1085 C  CZ  . PHE A 1 140 ? -12.63985 0.77700   -23.24513 1.000 21.51551 ? 140 PHE A CZ  1 
ATOM   1086 N  N   . LEU A 1 141 ? -14.83413 -5.68498  -21.39820 1.000 22.53092 ? 141 LEU A N   1 
ATOM   1087 C  CA  . LEU A 1 141 ? -15.70084 -6.85171  -21.34646 1.000 24.05179 ? 141 LEU A CA  1 
ATOM   1088 C  C   . LEU A 1 141 ? -17.13582 -6.43790  -21.64059 1.000 24.96634 ? 141 LEU A C   1 
ATOM   1089 O  O   . LEU A 1 141 ? -17.45068 -5.25119  -21.76945 1.000 22.89395 ? 141 LEU A O   1 
ATOM   1090 C  CB  . LEU A 1 141 ? -15.61230 -7.54037  -19.97999 1.000 24.26789 ? 141 LEU A CB  1 
ATOM   1091 C  CG  . LEU A 1 141 ? -14.19285 -7.96872  -19.58490 1.000 25.62151 ? 141 LEU A CG  1 
ATOM   1092 C  CD1 . LEU A 1 141 ? -14.20085 -8.53974  -18.18146 1.000 28.13281 ? 141 LEU A CD1 1 
ATOM   1093 C  CD2 . LEU A 1 141 ? -13.62168 -8.97773  -20.59291 1.000 25.48264 ? 141 LEU A CD2 1 
ATOM   1094 N  N   . ASN A 1 142 ? -18.00744 -7.43646  -21.76997 1.000 23.71613 ? 142 ASN A N   1 
ATOM   1095 C  CA  . ASN A 1 142 ? -19.42963 -7.14927  -21.87953 1.000 25.06853 ? 142 ASN A CA  1 
ATOM   1096 C  C   . ASN A 1 142 ? -19.84704 -6.26495  -20.71544 1.000 21.24601 ? 142 ASN A C   1 
ATOM   1097 O  O   . ASN A 1 142 ? -19.40363 -6.45864  -19.57854 1.000 21.49921 ? 142 ASN A O   1 
ATOM   1098 C  CB  . ASN A 1 142 ? -20.25157 -8.44086  -21.88856 1.000 26.26660 ? 142 ASN A CB  1 
ATOM   1099 C  CG  . ASN A 1 142 ? -21.72088 -8.19164  -22.20513 1.000 36.15729 ? 142 ASN A CG  1 
ATOM   1100 O  OD1 . ASN A 1 142 ? -22.05761 -7.30441  -22.98870 1.000 34.68408 ? 142 ASN A OD1 1 
ATOM   1101 N  ND2 . ASN A 1 142 ? -22.59961 -8.96410  -21.58304 1.000 38.82486 ? 142 ASN A ND2 1 
ATOM   1102 N  N   . GLY A 1 143 ? -20.66178 -5.25754  -21.01727 1.000 22.01521 ? 143 GLY A N   1 
ATOM   1103 C  CA  . GLY A 1 143 ? -21.09335 -4.29827  -20.03228 1.000 20.14922 ? 143 GLY A CA  1 
ATOM   1104 C  C   . GLY A 1 143 ? -20.21184 -3.07433  -19.90634 1.000 23.49295 ? 143 GLY A C   1 
ATOM   1105 O  O   . GLY A 1 143 ? -20.53954 -2.17039  -19.11809 1.000 20.01912 ? 143 GLY A O   1 
ATOM   1106 N  N   . SER A 1 144 ? -19.09499 -3.01953  -20.63733 1.000 16.66147 ? 144 SER A N   1 
ATOM   1107 C  CA  . SER A 1 144 ? -18.18907 -1.88342  -20.54607 1.000 17.19019 ? 144 SER A CA  1 
ATOM   1108 C  C   . SER A 1 144 ? -18.60205 -0.71492  -21.42392 1.000 18.68843 ? 144 SER A C   1 
ATOM   1109 O  O   . SER A 1 144 ? -18.00911 0.36147   -21.28995 1.000 16.47451 ? 144 SER A O   1 
ATOM   1110 C  CB  . SER A 1 144 ? -16.77150 -2.30805  -20.92625 1.000 17.78381 ? 144 SER A CB  1 
ATOM   1111 O  OG  . SER A 1 144 ? -16.74787 -2.82044  -22.24980 1.000 21.04778 ? 144 SER A OG  1 
ATOM   1112 N  N   . CYS A 1 145 ? -19.57243 -0.90224  -22.32718 1.000 17.69224 ? 145 CYS A N   1 
ATOM   1113 C  CA  . CYS A 1 145 ? -19.96968 0.18051   -23.22017 1.000 18.27741 ? 145 CYS A CA  1 
ATOM   1114 C  C   . CYS A 1 145 ? -20.37299 1.40550   -22.41223 1.000 16.44207 ? 145 CYS A C   1 
ATOM   1115 O  O   . CYS A 1 145 ? -20.95366 1.29344   -21.33273 1.000 19.29481 ? 145 CYS A O   1 
ATOM   1116 C  CB  . CYS A 1 145 ? -21.12160 -0.26075  -24.12441 1.000 21.84293 ? 145 CYS A CB  1 
ATOM   1117 S  SG  . CYS A 1 145 ? -20.83828 -1.84271  -24.93315 1.000 24.20228 ? 145 CYS A SG  1 
ATOM   1118 N  N   . GLY A 1 146 ? -20.04134 2.58422   -22.93008 1.000 17.36455 ? 146 GLY A N   1 
ATOM   1119 C  CA  . GLY A 1 146 ? -20.24109 3.80872   -22.20129 1.000 18.00601 ? 146 GLY A CA  1 
ATOM   1120 C  C   . GLY A 1 146 ? -19.06308 4.26497   -21.36441 1.000 22.27778 ? 146 GLY A C   1 
ATOM   1121 O  O   . GLY A 1 146 ? -19.05664 5.42141   -20.92880 1.000 17.71991 ? 146 GLY A O   1 
ATOM   1122 N  N   . SER A 1 147 ? -18.08669 3.38917   -21.08833 1.000 16.64508 ? 147 SER A N   1 
ATOM   1123 C  CA  . SER A 1 147 ? -16.82431 3.84703   -20.51055 1.000 13.63968 ? 147 SER A CA  1 
ATOM   1124 C  C   . SER A 1 147 ? -16.20302 4.91408   -21.40966 1.000 14.36910 ? 147 SER A C   1 
ATOM   1125 O  O   . SER A 1 147 ? -16.36936 4.89086   -22.62469 1.000 14.54425 ? 147 SER A O   1 
ATOM   1126 C  CB  . SER A 1 147 ? -15.83525 2.68258   -20.36259 1.000 16.43301 ? 147 SER A CB  1 
ATOM   1127 O  OG  . SER A 1 147 ? -16.36460 1.59734   -19.62319 1.000 19.35551 ? 147 SER A OG  1 
ATOM   1128 N  N   . VAL A 1 148 ? -15.44995 5.84552   -20.82136 1.000 15.63546 ? 148 VAL A N   1 
ATOM   1129 C  CA  . VAL A 1 148 ? -14.95322 6.95846   -21.61795 1.000 13.97418 ? 148 VAL A CA  1 
ATOM   1130 C  C   . VAL A 1 148 ? -13.43374 7.06338   -21.54640 1.000 17.40847 ? 148 VAL A C   1 
ATOM   1131 O  O   . VAL A 1 148 ? -12.79000 6.61337   -20.59555 1.000 16.39016 ? 148 VAL A O   1 
ATOM   1132 C  CB  . VAL A 1 148 ? -15.59373 8.30164   -21.21702 1.000 17.44757 ? 148 VAL A CB  1 
ATOM   1133 C  CG1 . VAL A 1 148 ? -17.06856 8.30205   -21.60413 1.000 17.67557 ? 148 VAL A CG1 1 
ATOM   1134 C  CG2 . VAL A 1 148 ? -15.41934 8.57162   -19.72161 1.000 16.28689 ? 148 VAL A CG2 1 
ATOM   1135 N  N   . GLY A 1 149 ? -12.87388 7.68176   -22.58951 1.000 17.69221 ? 149 GLY A N   1 
ATOM   1136 C  CA  . GLY A 1 149 ? -11.47239 8.04979   -22.64013 1.000 14.76415 ? 149 GLY A CA  1 
ATOM   1137 C  C   . GLY A 1 149 ? -11.33480 9.54989   -22.46643 1.000 18.94013 ? 149 GLY A C   1 
ATOM   1138 O  O   . GLY A 1 149 ? -12.22873 10.31551  -22.84368 1.000 17.71491 ? 149 GLY A O   1 
ATOM   1139 N  N   . PHE A 1 150 ? -10.21267 9.97650   -21.88913 1.000 18.11309 ? 150 PHE A N   1 
ATOM   1140 C  CA  . PHE A 1 150 ? -10.09702 11.37198  -21.50570 1.000 18.25478 ? 150 PHE A CA  1 
ATOM   1141 C  C   . PHE A 1 150 ? -8.63542  11.74696  -21.33157 1.000 19.56038 ? 150 PHE A C   1 
ATOM   1142 O  O   . PHE A 1 150 ? -7.78741  10.89271  -21.06622 1.000 17.95050 ? 150 PHE A O   1 
ATOM   1143 C  CB  . PHE A 1 150 ? -10.86224 11.64520  -20.20757 1.000 16.77973 ? 150 PHE A CB  1 
ATOM   1144 C  CG  . PHE A 1 150 ? -10.36322 10.83836  -19.04674 1.000 21.36162 ? 150 PHE A CG  1 
ATOM   1145 C  CD1 . PHE A 1 150 ? -10.78415 9.52839   -18.86076 1.000 19.46024 ? 150 PHE A CD1 1 
ATOM   1146 C  CD2 . PHE A 1 150 ? -9.45304  11.37891  -18.15194 1.000 16.07544 ? 150 PHE A CD2 1 
ATOM   1147 C  CE1 . PHE A 1 150 ? -10.31080 8.77863   -17.78867 1.000 19.17853 ? 150 PHE A CE1 1 
ATOM   1148 C  CE2 . PHE A 1 150 ? -8.97328  10.62858  -17.08542 1.000 19.33463 ? 150 PHE A CE2 1 
ATOM   1149 C  CZ  . PHE A 1 150 ? -9.40598  9.33020   -16.90746 1.000 20.29142 ? 150 PHE A CZ  1 
ATOM   1150 N  N   . ASN A 1 151 ? -8.36128  13.03985  -21.48213 1.000 20.14517 ? 151 ASN A N   1 
ATOM   1151 C  CA  . ASN A 1 151 ? -7.15095  13.66291  -20.97526 1.000 22.04373 ? 151 ASN A CA  1 
ATOM   1152 C  C   . ASN A 1 151 ? -7.54443  14.70100  -19.93203 1.000 22.53027 ? 151 ASN A C   1 
ATOM   1153 O  O   . ASN A 1 151 ? -8.69637  15.14711  -19.86320 1.000 22.87946 ? 151 ASN A O   1 
ATOM   1154 C  CB  . ASN A 1 151 ? -6.32662  14.32835  -22.08836 1.000 22.21326 ? 151 ASN A CB  1 
ATOM   1155 C  CG  . ASN A 1 151 ? -5.76582  13.33065  -23.07617 1.000 25.92746 ? 151 ASN A CG  1 
ATOM   1156 O  OD1 . ASN A 1 151 ? -4.63987  12.85830  -22.92642 1.000 26.86703 ? 151 ASN A OD1 1 
ATOM   1157 N  ND2 . ASN A 1 151 ? -6.54452  13.00727  -24.10129 1.000 23.77992 ? 151 ASN A ND2 1 
ATOM   1158 N  N   . ILE A 1 152 ? -6.58045  15.07709  -19.10345 1.000 24.39072 ? 152 ILE A N   1 
ATOM   1159 C  CA  . ILE A 1 152 ? -6.78931  16.10476  -18.09716 1.000 22.75762 ? 152 ILE A CA  1 
ATOM   1160 C  C   . ILE A 1 152 ? -5.65747  17.10595  -18.23021 1.000 31.30349 ? 152 ILE A C   1 
ATOM   1161 O  O   . ILE A 1 152 ? -4.48556  16.72780  -18.18870 1.000 28.55635 ? 152 ILE A O   1 
ATOM   1162 C  CB  . ILE A 1 152 ? -6.84370  15.52812  -16.67230 1.000 26.22230 ? 152 ILE A CB  1 
ATOM   1163 C  CG1 . ILE A 1 152 ? -7.93189  14.45898  -16.56945 1.000 24.54346 ? 152 ILE A CG1 1 
ATOM   1164 C  CG2 . ILE A 1 152 ? -7.10857  16.63729  -15.66742 1.000 27.15473 ? 152 ILE A CG2 1 
ATOM   1165 C  CD1 . ILE A 1 152 ? -8.17187  13.97003  -15.14697 1.000 27.49832 ? 152 ILE A CD1 1 
ATOM   1166 N  N   . ASP A 1 153 ? -6.00122  18.37689  -18.39271 1.000 35.81081 ? 153 ASP A N   1 
ATOM   1167 C  CA  . ASP A 1 153 ? -5.00736  19.43131  -18.52552 1.000 37.24629 ? 153 ASP A CA  1 
ATOM   1168 C  C   . ASP A 1 153 ? -5.36386  20.52470  -17.53391 1.000 41.04755 ? 153 ASP A C   1 
ATOM   1169 O  O   . ASP A 1 153 ? -6.44803  21.10928  -17.61859 1.000 41.92353 ? 153 ASP A O   1 
ATOM   1170 C  CB  . ASP A 1 153 ? -4.96013  19.94702  -19.96559 1.000 37.44455 ? 153 ASP A CB  1 
ATOM   1171 C  CG  . ASP A 1 153 ? -4.48156  18.87666  -20.94823 1.000 44.96910 ? 153 ASP A CG  1 
ATOM   1172 O  OD1 . ASP A 1 153 ? -3.26007  18.58833  -20.98048 1.000 42.67092 ? 153 ASP A OD1 1 
ATOM   1173 O  OD2 . ASP A 1 153 ? -5.33353  18.29847  -21.66353 1.000 44.04677 ? 153 ASP A OD2 1 
ATOM   1174 N  N   . TYR A 1 154 ? -4.45888  20.78325  -16.58884 1.000 41.83925 ? 154 TYR A N   1 
ATOM   1175 C  CA  . TYR A 1 154 ? -4.74868  21.57198  -15.38835 1.000 43.61719 ? 154 TYR A CA  1 
ATOM   1176 C  C   . TYR A 1 154 ? -5.87502  20.85121  -14.65460 1.000 50.23106 ? 154 TYR A C   1 
ATOM   1177 O  O   . TYR A 1 154 ? -5.65367  19.71915  -14.18447 1.000 49.25033 ? 154 TYR A O   1 
ATOM   1178 C  CB  . TYR A 1 154 ? -5.01821  23.02968  -15.77166 1.000 43.28308 ? 154 TYR A CB  1 
ATOM   1179 N  N   . ASP A 1 155 ? -7.06922  21.43233  -14.52578 1.000 42.25129 ? 155 ASP A N   1 
ATOM   1180 C  CA  . ASP A 1 155 ? -8.19127  20.75367  -13.89022 1.000 40.01411 ? 155 ASP A CA  1 
ATOM   1181 C  C   . ASP A 1 155 ? -9.34139  20.49536  -14.86048 1.000 37.46382 ? 155 ASP A C   1 
ATOM   1182 O  O   . ASP A 1 155 ? -10.45194 20.15929  -14.42861 1.000 35.40532 ? 155 ASP A O   1 
ATOM   1183 C  CB  . ASP A 1 155 ? -8.68314  21.55215  -12.68310 1.000 52.24234 ? 155 ASP A CB  1 
ATOM   1184 C  CG  . ASP A 1 155 ? -8.08340  21.06399  -11.37374 1.000 62.24690 ? 155 ASP A CG  1 
ATOM   1185 O  OD1 . ASP A 1 155 ? -7.06547  20.33751  -11.40834 1.000 59.29869 ? 155 ASP A OD1 1 
ATOM   1186 O  OD2 . ASP A 1 155 ? -8.64509  21.39793  -10.30739 1.000 70.07826 ? 155 ASP A OD2 1 
ATOM   1187 N  N   . CYS A 1 156 ? -9.09829  20.62969  -16.16312 1.000 32.69061 ? 156 CYS A N   1 
ATOM   1188 C  CA  . CYS A 1 156 ? -10.13507 20.44755  -17.17133 1.000 31.18330 ? 156 CYS A CA  1 
ATOM   1189 C  C   . CYS A 1 156 ? -10.01936 19.05125  -17.77252 1.000 26.43161 ? 156 CYS A C   1 
ATOM   1190 O  O   . CYS A 1 156 ? -8.95980  18.67838  -18.29088 1.000 28.91185 ? 156 CYS A O   1 
ATOM   1191 C  CB  . CYS A 1 156 ? -10.03278 21.51014  -18.26288 1.000 33.42837 ? 156 CYS A CB  1 
ATOM   1192 S  SG  . CYS A 1 156 ? -11.39287 21.45297  -19.44700 1.000 29.70340 ? 156 CYS A SG  1 
ATOM   1193 N  N   . VAL A 1 157 ? -11.10114 18.28576  -17.68777 1.000 23.17321 ? 157 VAL A N   1 
ATOM   1194 C  CA  . VAL A 1 157 ? -11.17478 16.95728  -18.28571 1.000 24.81875 ? 157 VAL A CA  1 
ATOM   1195 C  C   . VAL A 1 157 ? -11.65480 17.10124  -19.72515 1.000 26.59389 ? 157 VAL A C   1 
ATOM   1196 O  O   . VAL A 1 157 ? -12.77942 17.55206  -19.96853 1.000 25.38964 ? 157 VAL A O   1 
ATOM   1197 C  CB  . VAL A 1 157 ? -12.12010 16.04337  -17.49522 1.000 25.48362 ? 157 VAL A CB  1 
ATOM   1198 C  CG1 . VAL A 1 157 ? -12.15016 14.65069  -18.12363 1.000 26.98062 ? 157 VAL A CG1 1 
ATOM   1199 C  CG2 . VAL A 1 157 ? -11.73093 15.99299  -16.03304 1.000 23.69422 ? 157 VAL A CG2 1 
ATOM   1200 N  N   . SER A 1 158 ? -10.82214 16.70591  -20.68197 1.000 19.62676 ? 158 SER A N   1 
ATOM   1201 C  CA  . SER A 1 158 ? -11.23045 16.70560  -22.08399 1.000 23.50707 ? 158 SER A CA  1 
ATOM   1202 C  C   . SER A 1 158 ? -11.63455 15.27942  -22.44735 1.000 22.52784 ? 158 SER A C   1 
ATOM   1203 O  O   . SER A 1 158 ? -10.78325 14.40734  -22.62449 1.000 21.16209 ? 158 SER A O   1 
ATOM   1204 C  CB  . SER A 1 158 ? -10.12098 17.24505  -22.97997 1.000 22.17356 ? 158 SER A CB  1 
ATOM   1205 O  OG  . SER A 1 158 ? -8.91122  16.53949  -22.76717 1.000 29.91925 ? 158 SER A OG  1 
ATOM   1206 N  N   . PHE A 1 159 ? -12.94298 15.03693  -22.52689 1.000 20.69466 ? 159 PHE A N   1 
ATOM   1207 C  CA  . PHE A 1 159 ? -13.45048 13.73143  -22.91914 1.000 20.22996 ? 159 PHE A CA  1 
ATOM   1208 C  C   . PHE A 1 159 ? -13.29919 13.57378  -24.42381 1.000 20.92893 ? 159 PHE A C   1 
ATOM   1209 O  O   . PHE A 1 159 ? -13.71507 14.44876  -25.18648 1.000 23.04280 ? 159 PHE A O   1 
ATOM   1210 C  CB  . PHE A 1 159 ? -14.91984 13.57545  -22.51174 1.000 20.40899 ? 159 PHE A CB  1 
ATOM   1211 C  CG  . PHE A 1 159 ? -15.14924 13.60440  -21.02354 1.000 22.81165 ? 159 PHE A CG  1 
ATOM   1212 C  CD1 . PHE A 1 159 ? -14.90399 12.47549  -20.24905 1.000 21.94240 ? 159 PHE A CD1 1 
ATOM   1213 C  CD2 . PHE A 1 159 ? -15.60885 14.75591  -20.39736 1.000 21.32412 ? 159 PHE A CD2 1 
ATOM   1214 C  CE1 . PHE A 1 159 ? -15.10928 12.49517  -18.88371 1.000 18.20156 ? 159 PHE A CE1 1 
ATOM   1215 C  CE2 . PHE A 1 159 ? -15.82205 14.78109  -19.02797 1.000 19.34873 ? 159 PHE A CE2 1 
ATOM   1216 C  CZ  . PHE A 1 159 ? -15.57882 13.64861  -18.27026 1.000 21.12280 ? 159 PHE A CZ  1 
ATOM   1217 N  N   . CYS A 1 160 ? -12.70337 12.46132  -24.85453 1.000 17.47578 ? 160 CYS A N   1 
ATOM   1218 C  CA  . CYS A 1 160 ? -12.44237 12.25278  -26.26827 1.000 17.61276 ? 160 CYS A CA  1 
ATOM   1219 C  C   . CYS A 1 160 ? -12.96203 10.94022  -26.83228 1.000 18.35027 ? 160 CYS A C   1 
ATOM   1220 O  O   . CYS A 1 160 ? -12.92670 10.77096  -28.05382 1.000 20.48467 ? 160 CYS A O   1 
ATOM   1221 C  CB  . CYS A 1 160 ? -10.93576 12.33359  -26.55120 1.000 23.01093 ? 160 CYS A CB  1 
ATOM   1222 S  SG  . CYS A 1 160 ? -9.99717  11.09284  -25.65767 1.000 21.26599 ? 160 CYS A SG  1 
ATOM   1223 N  N   . TYR A 1 161 ? -13.44901 10.01863  -26.00645 1.000 18.84153 ? 161 TYR A N   1 
ATOM   1224 C  CA  . TYR A 1 161 ? -13.84534 8.70227   -26.48555 1.000 17.45274 ? 161 TYR A CA  1 
ATOM   1225 C  C   . TYR A 1 161 ? -14.94990 8.14977   -25.60069 1.000 15.92487 ? 161 TYR A C   1 
ATOM   1226 O  O   . TYR A 1 161 ? -14.89060 8.26966   -24.37600 1.000 16.54633 ? 161 TYR A O   1 
ATOM   1227 C  CB  . TYR A 1 161 ? -12.65446 7.73832   -26.48984 1.000 16.32561 ? 161 TYR A CB  1 
ATOM   1228 C  CG  . TYR A 1 161 ? -12.95630 6.31338   -26.92800 1.000 13.92585 ? 161 TYR A CG  1 
ATOM   1229 C  CD1 . TYR A 1 161 ? -12.93806 5.95515   -28.26772 1.000 16.96819 ? 161 TYR A CD1 1 
ATOM   1230 C  CD2 . TYR A 1 161 ? -13.22642 5.32015   -25.99392 1.000 17.28482 ? 161 TYR A CD2 1 
ATOM   1231 C  CE1 . TYR A 1 161 ? -13.20916 4.63766   -28.67018 1.000 17.68260 ? 161 TYR A CE1 1 
ATOM   1232 C  CE2 . TYR A 1 161 ? -13.49043 4.00486   -26.38195 1.000 14.42570 ? 161 TYR A CE2 1 
ATOM   1233 C  CZ  . TYR A 1 161 ? -13.47974 3.67169   -27.71794 1.000 16.83757 ? 161 TYR A CZ  1 
ATOM   1234 O  OH  . TYR A 1 161 ? -13.74640 2.37214   -28.09955 1.000 19.38677 ? 161 TYR A OH  1 
ATOM   1235 N  N   . MET A 1 162 ? -15.95667 7.54978   -26.22517 1.000 17.54968 ? 162 MET A N   1 
ATOM   1236 C  CA  . MET A 1 162 ? -16.93411 6.73557   -25.51963 1.000 16.88870 ? 162 MET A CA  1 
ATOM   1237 C  C   . MET A 1 162 ? -16.95791 5.35977   -26.16733 1.000 15.47790 ? 162 MET A C   1 
ATOM   1238 O  O   . MET A 1 162 ? -17.10519 5.25272   -27.38217 1.000 16.67691 ? 162 MET A O   1 
ATOM   1239 C  CB  . MET A 1 162 ? -18.33392 7.35673   -25.54967 1.000 14.60639 ? 162 MET A CB  1 
ATOM   1240 C  CG  . MET A 1 162 ? -19.37158 6.44325   -24.88901 1.000 17.27661 ? 162 MET A CG  1 
ATOM   1241 S  SD  . MET A 1 162 ? -20.94253 7.27011   -24.52098 1.000 23.91260 ? 162 MET A SD  1 
ATOM   1242 C  CE  . MET A 1 162 ? -20.51446 8.18274   -23.05206 1.000 17.72239 ? 162 MET A CE  1 
ATOM   1243 N  N   . HIS A 1 163 ? -16.83193 4.31453   -25.35998 1.000 16.41560 ? 163 HIS A N   1 
ATOM   1244 C  CA  . HIS A 1 163 ? -16.71294 2.96796   -25.89530 1.000 17.97327 ? 163 HIS A CA  1 
ATOM   1245 C  C   . HIS A 1 163 ? -18.07830 2.45019   -26.32436 1.000 18.74364 ? 163 HIS A C   1 
ATOM   1246 O  O   . HIS A 1 163 ? -19.05430 2.55239   -25.57494 1.000 18.34512 ? 163 HIS A O   1 
ATOM   1247 C  CB  . HIS A 1 163 ? -16.09184 2.03928   -24.85619 1.000 16.43818 ? 163 HIS A CB  1 
ATOM   1248 C  CG  . HIS A 1 163 ? -15.90529 0.63727   -25.34019 1.000 18.16839 ? 163 HIS A CG  1 
ATOM   1249 N  ND1 . HIS A 1 163 ? -15.30276 0.34001   -26.54241 1.000 18.40644 ? 163 HIS A ND1 1 
ATOM   1250 C  CD2 . HIS A 1 163 ? -16.24413 -0.54997  -24.78464 1.000 17.20306 ? 163 HIS A CD2 1 
ATOM   1251 C  CE1 . HIS A 1 163 ? -15.27466 -0.97053  -26.70748 1.000 19.55260 ? 163 HIS A CE1 1 
ATOM   1252 N  NE2 . HIS A 1 163 ? -15.84303 -1.53433  -25.65615 1.000 21.83226 ? 163 HIS A NE2 1 
ATOM   1253 N  N   . HIS A 1 164 ? -18.14594 1.90414   -27.53833 1.000 19.11043 ? 164 HIS A N   1 
ATOM   1254 C  CA  . HIS A 1 164 ? -19.37689 1.33824   -28.07411 1.000 17.41979 ? 164 HIS A CA  1 
ATOM   1255 C  C   . HIS A 1 164 ? -19.30714 -0.15812  -28.32715 1.000 21.03910 ? 164 HIS A C   1 
ATOM   1256 O  O   . HIS A 1 164 ? -20.27716 -0.86549  -28.03512 1.000 22.44634 ? 164 HIS A O   1 
ATOM   1257 C  CB  . HIS A 1 164 ? -19.77541 2.05505   -29.37649 1.000 18.03318 ? 164 HIS A CB  1 
ATOM   1258 C  CG  . HIS A 1 164 ? -20.37994 3.40922   -29.16577 1.000 16.73983 ? 164 HIS A CG  1 
ATOM   1259 N  ND1 . HIS A 1 164 ? -21.68106 3.70674   -29.51747 1.000 18.07969 ? 164 HIS A ND1 1 
ATOM   1260 C  CD2 . HIS A 1 164 ? -19.86283 4.54618   -28.64326 1.000 18.43130 ? 164 HIS A CD2 1 
ATOM   1261 C  CE1 . HIS A 1 164 ? -21.93684 4.96970   -29.22381 1.000 18.43145 ? 164 HIS A CE1 1 
ATOM   1262 N  NE2 . HIS A 1 164 ? -20.85151 5.50126   -28.68961 1.000 19.00105 ? 164 HIS A NE2 1 
ATOM   1263 N  N   . MET A 1 165 ? -18.20477 -0.68158  -28.86015 1.000 19.07458 ? 165 MET A N   1 
ATOM   1264 C  CA  . MET A 1 165 ? -18.26348 -2.06902  -29.30276 1.000 21.82071 ? 165 MET A CA  1 
ATOM   1265 C  C   . MET A 1 165 ? -16.87522 -2.66817  -29.47974 1.000 22.28002 ? 165 MET A C   1 
ATOM   1266 O  O   . MET A 1 165 ? -15.87906 -1.96037  -29.65324 1.000 17.69080 ? 165 MET A O   1 
ATOM   1267 C  CB  . MET A 1 165 ? -19.04268 -2.18746  -30.60881 1.000 22.79532 ? 165 MET A CB  1 
ATOM   1268 C  CG  . MET A 1 165 ? -18.47591 -1.34694  -31.71173 1.000 24.33633 ? 165 MET A CG  1 
ATOM   1269 S  SD  . MET A 1 165 ? -19.62937 -1.25782  -33.10682 1.000 34.44392 ? 165 MET A SD  1 
ATOM   1270 C  CE  . MET A 1 165 ? -18.64276 -0.29862  -34.23033 1.000 23.01888 ? 165 MET A CE  1 
ATOM   1271 N  N   . GLU A 1 166 ? -16.83952 -3.99704  -29.45233 1.000 21.66577 ? 166 GLU A N   1 
ATOM   1272 C  CA  . GLU A 1 166 ? -15.63989 -4.77386  -29.73603 1.000 24.60209 ? 166 GLU A CA  1 
ATOM   1273 C  C   . GLU A 1 166 ? -15.80407 -5.44133  -31.09685 1.000 28.82592 ? 166 GLU A C   1 
ATOM   1274 O  O   . GLU A 1 166 ? -16.78536 -6.15537  -31.32632 1.000 27.13299 ? 166 GLU A O   1 
ATOM   1275 C  CB  . GLU A 1 166 ? -15.38740 -5.82092  -28.65397 1.000 24.89356 ? 166 GLU A CB  1 
ATOM   1276 C  CG  . GLU A 1 166 ? -14.12961 -6.65022  -28.90247 1.000 27.33378 ? 166 GLU A CG  1 
ATOM   1277 C  CD  . GLU A 1 166 ? -13.79454 -7.57151  -27.75202 1.000 30.13232 ? 166 GLU A CD  1 
ATOM   1278 O  OE1 . GLU A 1 166 ? -13.53538 -7.06632  -26.63699 1.000 29.56769 ? 166 GLU A OE1 1 
ATOM   1279 O  OE2 . GLU A 1 166 ? -13.79300 -8.80502  -27.95818 1.000 31.07521 ? 166 GLU A OE2 1 
ATOM   1280 N  N   . LEU A 1 167 ? -14.85561 -5.19057  -31.99465 1.000 28.62672 ? 167 LEU A N   1 
ATOM   1281 C  CA  . LEU A 1 167 ? -14.87082 -5.78955  -33.31554 1.000 28.94639 ? 167 LEU A CA  1 
ATOM   1282 C  C   . LEU A 1 167 ? -14.46574 -7.25663  -33.22156 1.000 31.30828 ? 167 LEU A C   1 
ATOM   1283 O  O   . LEU A 1 167 ? -13.85931 -7.67326  -32.23451 1.000 32.60963 ? 167 LEU A O   1 
ATOM   1284 C  CB  . LEU A 1 167 ? -13.92690 -5.02782  -34.24279 1.000 30.12969 ? 167 LEU A CB  1 
ATOM   1285 C  CG  . LEU A 1 167 ? -14.31495 -3.56644  -34.48787 1.000 31.91782 ? 167 LEU A CG  1 
ATOM   1286 C  CD1 . LEU A 1 167 ? -13.13294 -2.77463  -35.02969 1.000 29.69804 ? 167 LEU A CD1 1 
ATOM   1287 C  CD2 . LEU A 1 167 ? -15.48957 -3.47922  -35.43819 1.000 32.35686 ? 167 LEU A CD2 1 
ATOM   1288 N  N   . PRO A 1 168 ? -14.79667 -8.06505  -34.23575 1.000 35.31508 ? 168 PRO A N   1 
ATOM   1289 C  CA  . PRO A 1 168 ? -14.47280 -9.50206  -34.16189 1.000 36.65927 ? 168 PRO A CA  1 
ATOM   1290 C  C   . PRO A 1 168 ? -13.00908 -9.81345  -33.88804 1.000 32.35195 ? 168 PRO A C   1 
ATOM   1291 O  O   . PRO A 1 168 ? -12.71913 -10.84960 -33.28103 1.000 36.35564 ? 168 PRO A O   1 
ATOM   1292 C  CB  . PRO A 1 168 ? -14.91060 -10.02109 -35.53816 1.000 32.73096 ? 168 PRO A CB  1 
ATOM   1293 C  CG  . PRO A 1 168 ? -16.02562 -9.12793  -35.91519 1.000 38.03592 ? 168 PRO A CG  1 
ATOM   1294 C  CD  . PRO A 1 168 ? -15.63329 -7.76146  -35.41116 1.000 35.93419 ? 168 PRO A CD  1 
ATOM   1295 N  N   . THR A 1 169 ? -12.08076 -8.95176  -34.29599 1.000 34.57543 ? 169 THR A N   1 
ATOM   1296 C  CA  . THR A 1 169 ? -10.65781 -9.19515  -34.08542 1.000 31.93918 ? 169 THR A CA  1 
ATOM   1297 C  C   . THR A 1 169 ? -10.17875 -8.85612  -32.67588 1.000 39.22494 ? 169 THR A C   1 
ATOM   1298 O  O   . THR A 1 169 ? -8.98296  -9.00328  -32.39535 1.000 38.68267 ? 169 THR A O   1 
ATOM   1299 C  CB  . THR A 1 169 ? -9.84011  -8.39469  -35.09202 1.000 40.51237 ? 169 THR A CB  1 
ATOM   1300 O  OG1 . THR A 1 169 ? -10.13778 -7.00107  -34.93392 1.000 38.63844 ? 169 THR A OG1 1 
ATOM   1301 C  CG2 . THR A 1 169 ? -10.18538 -8.83043  -36.51309 1.000 38.38247 ? 169 THR A CG2 1 
ATOM   1302 N  N   . GLY A 1 170 ? -11.05820 -8.39868  -31.78887 1.000 33.06517 ? 170 GLY A N   1 
ATOM   1303 C  CA  . GLY A 1 170 ? -10.66702 -8.12427  -30.42369 1.000 32.90863 ? 170 GLY A CA  1 
ATOM   1304 C  C   . GLY A 1 170 ? -10.27448 -6.69393  -30.12162 1.000 29.28524 ? 170 GLY A C   1 
ATOM   1305 O  O   . GLY A 1 170 ? -9.89279  -6.40980  -28.98060 1.000 34.58179 ? 170 GLY A O   1 
ATOM   1306 N  N   . VAL A 1 171 ? -10.34416 -5.78769  -31.09800 1.000 26.50927 ? 171 VAL A N   1 
ATOM   1307 C  CA  . VAL A 1 171 ? -10.03145 -4.37980  -30.86503 1.000 26.74370 ? 171 VAL A CA  1 
ATOM   1308 C  C   . VAL A 1 171 ? -11.34006 -3.61051  -30.73601 1.000 25.58433 ? 171 VAL A C   1 
ATOM   1309 O  O   . VAL A 1 171 ? -12.42505 -4.16898  -30.93569 1.000 25.62823 ? 171 VAL A O   1 
ATOM   1310 C  CB  . VAL A 1 171 ? -9.14392  -3.80450  -31.98719 1.000 31.27125 ? 171 VAL A CB  1 
ATOM   1311 C  CG1 . VAL A 1 171 ? -7.83511  -4.58879  -32.08781 1.000 28.91968 ? 171 VAL A CG1 1 
ATOM   1312 C  CG2 . VAL A 1 171 ? -9.88740  -3.83684  -33.31261 1.000 26.95264 ? 171 VAL A CG2 1 
ATOM   1313 N  N   . HIS A 1 172 ? -11.25540 -2.32281  -30.41973 1.000 21.75628 ? 172 HIS A N   1 
ATOM   1314 C  CA  . HIS A 1 172 ? -12.41174 -1.60047  -29.91783 1.000 19.83692 ? 172 HIS A CA  1 
ATOM   1315 C  C   . HIS A 1 172 ? -12.69816 -0.34844  -30.73207 1.000 22.82324 ? 172 HIS A C   1 
ATOM   1316 O  O   . HIS A 1 172 ? -11.78681 0.30953   -31.24867 1.000 19.38545 ? 172 HIS A O   1 
ATOM   1317 C  CB  . HIS A 1 172 ? -12.18962 -1.28494  -28.43600 1.000 19.66401 ? 172 HIS A CB  1 
ATOM   1318 C  CG  . HIS A 1 172 ? -11.97922 -2.51868  -27.62021 1.000 21.32101 ? 172 HIS A CG  1 
ATOM   1319 N  ND1 . HIS A 1 172 ? -10.74741 -2.89023  -27.13046 1.000 19.40513 ? 172 HIS A ND1 1 
ATOM   1320 C  CD2 . HIS A 1 172 ? -12.83519 -3.51159  -27.28094 1.000 21.35956 ? 172 HIS A CD2 1 
ATOM   1321 C  CE1 . HIS A 1 172 ? -10.86206 -4.04084  -26.48937 1.000 22.95015 ? 172 HIS A CE1 1 
ATOM   1322 N  NE2 . HIS A 1 172 ? -12.11855 -4.44025  -26.56918 1.000 21.41982 ? 172 HIS A NE2 1 
ATOM   1323 N  N   . ALA A 1 173 ? -13.99134 -0.03154  -30.84770 1.000 18.16142 ? 173 ALA A N   1 
ATOM   1324 C  CA  . ALA A 1 173 ? -14.44025 1.11919   -31.60887 1.000 17.42462 ? 173 ALA A CA  1 
ATOM   1325 C  C   . ALA A 1 173 ? -15.43170 1.93075   -30.79428 1.000 17.84407 ? 173 ALA A C   1 
ATOM   1326 O  O   . ALA A 1 173 ? -16.19059 1.39320   -29.97700 1.000 19.37592 ? 173 ALA A O   1 
ATOM   1327 C  CB  . ALA A 1 173 ? -15.08338 0.70772   -32.96096 1.000 22.28091 ? 173 ALA A CB  1 
ATOM   1328 N  N   . GLY A 1 174 ? -15.40879 3.23732   -31.01971 1.000 18.92852 ? 174 GLY A N   1 
ATOM   1329 C  CA  . GLY A 1 174 ? -16.24936 4.12882   -30.25737 1.000 16.49628 ? 174 GLY A CA  1 
ATOM   1330 C  C   . GLY A 1 174 ? -16.39175 5.45448   -30.96311 1.000 17.05914 ? 174 GLY A C   1 
ATOM   1331 O  O   . GLY A 1 174 ? -15.97811 5.61356   -32.11209 1.000 17.29389 ? 174 GLY A O   1 
ATOM   1332 N  N   . THR A 1 175 ? -16.97308 6.41351   -30.24796 1.000 15.25895 ? 175 THR A N   1 
ATOM   1333 C  CA  . THR A 1 175 ? -17.30066 7.72114   -30.79092 1.000 18.26988 ? 175 THR A CA  1 
ATOM   1334 C  C   . THR A 1 175 ? -16.64524 8.80215   -29.94534 1.000 17.20754 ? 175 THR A C   1 
ATOM   1335 O  O   . THR A 1 175 ? -16.18262 8.54814   -28.83342 1.000 18.21348 ? 175 THR A O   1 
ATOM   1336 C  CB  . THR A 1 175 ? -18.82746 7.93276   -30.81511 1.000 18.02955 ? 175 THR A CB  1 
ATOM   1337 O  OG1 . THR A 1 175 ? -19.30514 8.03342   -29.47215 1.000 18.51720 ? 175 THR A OG1 1 
ATOM   1338 C  CG2 . THR A 1 175 ? -19.52034 6.75462   -31.48427 1.000 15.90354 ? 175 THR A CG2 1 
ATOM   1339 N  N   . ASP A 1 176 ? -16.62206 10.02317  -30.47733 1.000 16.42736 ? 176 ASP A N   1 
ATOM   1340 C  CA  . ASP A 1 176 ? -16.41313 11.18393  -29.62752 1.000 18.69227 ? 176 ASP A CA  1 
ATOM   1341 C  C   . ASP A 1 176 ? -17.68100 11.44002  -28.80394 1.000 19.39581 ? 176 ASP A C   1 
ATOM   1342 O  O   . ASP A 1 176 ? -18.68450 10.73244  -28.92499 1.000 18.65904 ? 176 ASP A O   1 
ATOM   1343 C  CB  . ASP A 1 176 ? -15.99907 12.40079  -30.46117 1.000 19.73390 ? 176 ASP A CB  1 
ATOM   1344 C  CG  . ASP A 1 176 ? -17.03731 12.81095  -31.51182 1.000 25.36011 ? 176 ASP A CG  1 
ATOM   1345 O  OD1 . ASP A 1 176 ? -18.23272 12.46639  -31.39282 1.000 24.75766 ? 176 ASP A OD1 1 
ATOM   1346 O  OD2 . ASP A 1 176 ? -16.63742 13.49799  -32.47723 1.000 25.52537 ? 176 ASP A OD2 1 
ATOM   1347 N  N   . LEU A 1 177 ? -17.64324 12.46134  -27.94924 1.000 18.80770 ? 177 LEU A N   1 
ATOM   1348 C  CA  . LEU A 1 177 ? -18.79815 12.74024  -27.09610 1.000 17.64072 ? 177 LEU A CA  1 
ATOM   1349 C  C   . LEU A 1 177 ? -19.88736 13.51724  -27.81811 1.000 21.87600 ? 177 LEU A C   1 
ATOM   1350 O  O   . LEU A 1 177 ? -20.90111 13.86501  -27.19890 1.000 25.76979 ? 177 LEU A O   1 
ATOM   1351 C  CB  . LEU A 1 177 ? -18.36555 13.48692  -25.82988 1.000 18.25411 ? 177 LEU A CB  1 
ATOM   1352 C  CG  . LEU A 1 177 ? -18.00396 12.57458  -24.64864 1.000 22.64398 ? 177 LEU A CG  1 
ATOM   1353 C  CD1 . LEU A 1 177 ? -19.24698 11.88008  -24.08886 1.000 21.77435 ? 177 LEU A CD1 1 
ATOM   1354 C  CD2 . LEU A 1 177 ? -16.95980 11.53673  -25.05257 1.000 20.56806 ? 177 LEU A CD2 1 
ATOM   1355 N  N   . GLU A 1 178 ? -19.70515 13.79690  -29.10048 1.000 21.71465 ? 178 GLU A N   1 
ATOM   1356 C  CA  . GLU A 1 178 ? -20.79736 14.19984  -29.96663 1.000 25.82924 ? 178 GLU A CA  1 
ATOM   1357 C  C   . GLU A 1 178 ? -21.39274 13.01508  -30.70834 1.000 24.31774 ? 178 GLU A C   1 
ATOM   1358 O  O   . GLU A 1 178 ? -22.26628 13.20370  -31.56005 1.000 23.25595 ? 178 GLU A O   1 
ATOM   1359 C  CB  . GLU A 1 178 ? -20.32216 15.26494  -30.95254 1.000 26.18050 ? 178 GLU A CB  1 
ATOM   1360 C  CG  . GLU A 1 178 ? -20.11848 16.61168  -30.30085 1.000 32.97533 ? 178 GLU A CG  1 
ATOM   1361 C  CD  . GLU A 1 178 ? -19.50548 17.63580  -31.23812 1.000 41.09235 ? 178 GLU A CD  1 
ATOM   1362 O  OE1 . GLU A 1 178 ? -18.60291 17.27111  -32.02587 1.000 45.06089 ? 178 GLU A OE1 1 
ATOM   1363 O  OE2 . GLU A 1 178 ? -19.93425 18.80673  -31.18338 1.000 43.90257 ? 178 GLU A OE2 1 
ATOM   1364 N  N   . GLY A 1 179 ? -20.93438 11.80136  -30.40358 1.000 20.77434 ? 179 GLY A N   1 
ATOM   1365 C  CA  . GLY A 1 179 ? -21.50041 10.60440  -30.98472 1.000 17.40839 ? 179 GLY A CA  1 
ATOM   1366 C  C   . GLY A 1 179 ? -21.05239 10.27015  -32.38753 1.000 22.39760 ? 179 GLY A C   1 
ATOM   1367 O  O   . GLY A 1 179 ? -21.65222 9.38617   -33.00729 1.000 20.48293 ? 179 GLY A O   1 
ATOM   1368 N  N   . ASN A 1 180 ? -20.02611 10.93572  -32.91495 1.000 19.83513 ? 180 ASN A N   1 
ATOM   1369 C  CA  . ASN A 1 180 ? -19.48875 10.59449  -34.22853 1.000 20.51666 ? 180 ASN A CA  1 
ATOM   1370 C  C   . ASN A 1 180 ? -18.41874 9.52567   -34.07526 1.000 22.85952 ? 180 ASN A C   1 
ATOM   1371 O  O   . ASN A 1 180 ? -17.44005 9.72087   -33.34147 1.000 21.99240 ? 180 ASN A O   1 
ATOM   1372 C  CB  . ASN A 1 180 ? -18.92248 11.82987  -34.92080 1.000 22.61169 ? 180 ASN A CB  1 
ATOM   1373 C  CG  . ASN A 1 180 ? -20.01180 12.76552  -35.37912 1.000 23.26853 ? 180 ASN A CG  1 
ATOM   1374 O  OD1 . ASN A 1 180 ? -20.91918 12.36124  -36.10814 1.000 25.89114 ? 180 ASN A OD1 1 
ATOM   1375 N  ND2 . ASN A 1 180 ? -19.96261 14.00371  -34.91255 1.000 30.02891 ? 180 ASN A ND2 1 
ATOM   1376 N  N   . PHE A 1 181 ? -18.60396 8.40315   -34.76638 1.000 20.16792 ? 181 PHE A N   1 
ATOM   1377 C  CA  . PHE A 1 181 ? -17.64649 7.31523   -34.66363 1.000 18.88172 ? 181 PHE A CA  1 
ATOM   1378 C  C   . PHE A 1 181 ? -16.27237 7.76152   -35.14399 1.000 23.63776 ? 181 PHE A C   1 
ATOM   1379 O  O   . PHE A 1 181 ? -16.14203 8.56771   -36.07223 1.000 22.62389 ? 181 PHE A O   1 
ATOM   1380 C  CB  . PHE A 1 181 ? -18.10803 6.10722   -35.47913 1.000 19.11185 ? 181 PHE A CB  1 
ATOM   1381 C  CG  . PHE A 1 181 ? -18.75103 5.03535   -34.65599 1.000 19.52113 ? 181 PHE A CG  1 
ATOM   1382 C  CD1 . PHE A 1 181 ? -17.97757 4.08966   -33.99685 1.000 17.79477 ? 181 PHE A CD1 1 
ATOM   1383 C  CD2 . PHE A 1 181 ? -20.12801 4.96562   -34.54108 1.000 21.00142 ? 181 PHE A CD2 1 
ATOM   1384 C  CE1 . PHE A 1 181 ? -18.56256 3.09131   -33.23294 1.000 19.87379 ? 181 PHE A CE1 1 
ATOM   1385 C  CE2 . PHE A 1 181 ? -20.72004 3.97918   -33.77203 1.000 21.62589 ? 181 PHE A CE2 1 
ATOM   1386 C  CZ  . PHE A 1 181 ? -19.93592 3.03790   -33.11257 1.000 20.16358 ? 181 PHE A CZ  1 
ATOM   1387 N  N   . TYR A 1 182 ? -15.24679 7.25115   -34.47891 1.000 18.10763 ? 182 TYR A N   1 
ATOM   1388 C  CA  . TYR A 1 182 ? -13.89931 7.29224   -35.01723 1.000 19.56931 ? 182 TYR A CA  1 
ATOM   1389 C  C   . TYR A 1 182 ? -13.78753 6.17999   -36.05144 1.000 21.45081 ? 182 TYR A C   1 
ATOM   1390 O  O   . TYR A 1 182 ? -14.07771 5.01646   -35.75151 1.000 20.69100 ? 182 TYR A O   1 
ATOM   1391 C  CB  . TYR A 1 182 ? -12.86835 7.11802   -33.90271 1.000 17.70159 ? 182 TYR A CB  1 
ATOM   1392 C  CG  . TYR A 1 182 ? -12.75173 8.29537   -32.95520 1.000 19.34463 ? 182 TYR A CG  1 
ATOM   1393 C  CD1 . TYR A 1 182 ? -12.01427 9.42412   -33.31061 1.000 20.61746 ? 182 TYR A CD1 1 
ATOM   1394 C  CD2 . TYR A 1 182 ? -13.35492 8.27576   -31.69390 1.000 18.69310 ? 182 TYR A CD2 1 
ATOM   1395 C  CE1 . TYR A 1 182 ? -11.89239 10.49725  -32.45381 1.000 19.79442 ? 182 TYR A CE1 1 
ATOM   1396 C  CE2 . TYR A 1 182 ? -13.23632 9.35591   -30.82570 1.000 15.71256 ? 182 TYR A CE2 1 
ATOM   1397 C  CZ  . TYR A 1 182 ? -12.50126 10.46384  -31.21654 1.000 19.80082 ? 182 TYR A CZ  1 
ATOM   1398 O  OH  . TYR A 1 182 ? -12.35566 11.55100  -30.38509 1.000 18.56554 ? 182 TYR A OH  1 
ATOM   1399 N  N   . GLY A 1 183 ? -13.41086 6.53922   -37.27188 1.000 21.28852 ? 183 GLY A N   1 
ATOM   1400 C  CA  . GLY A 1 183 ? -13.22995 5.57130   -38.32214 1.000 22.70776 ? 183 GLY A CA  1 
ATOM   1401 C  C   . GLY A 1 183 ? -14.52053 5.22040   -39.02646 1.000 24.53124 ? 183 GLY A C   1 
ATOM   1402 O  O   . GLY A 1 183 ? -15.55816 5.86538   -38.84210 1.000 25.64903 ? 183 GLY A O   1 
ATOM   1403 N  N   . PRO A 1 184 ? -14.47261 4.18735   -39.85658 1.000 24.86712 ? 184 PRO A N   1 
ATOM   1404 C  CA  . PRO A 1 184 ? -15.61922 3.87831   -40.72519 1.000 25.58958 ? 184 PRO A CA  1 
ATOM   1405 C  C   . PRO A 1 184 ? -16.65971 2.96748   -40.08868 1.000 30.59265 ? 184 PRO A C   1 
ATOM   1406 O  O   . PRO A 1 184 ? -17.43221 2.32676   -40.80857 1.000 31.39215 ? 184 PRO A O   1 
ATOM   1407 C  CB  . PRO A 1 184 ? -14.95857 3.19828   -41.93075 1.000 24.95803 ? 184 PRO A CB  1 
ATOM   1408 C  CG  . PRO A 1 184 ? -13.72308 2.53205   -41.35006 1.000 31.36545 ? 184 PRO A CG  1 
ATOM   1409 C  CD  . PRO A 1 184 ? -13.26573 3.41095   -40.20498 1.000 29.01293 ? 184 PRO A CD  1 
ATOM   1410 N  N   . PHE A 1 185 ? -16.71200 2.90281   -38.76062 1.000 23.66812 ? 185 PHE A N   1 
ATOM   1411 C  CA  . PHE A 1 185 ? -17.54565 1.90199   -38.11118 1.000 23.99071 ? 185 PHE A CA  1 
ATOM   1412 C  C   . PHE A 1 185 ? -18.94757 2.44437   -37.82527 1.000 21.71837 ? 185 PHE A C   1 
ATOM   1413 O  O   . PHE A 1 185 ? -19.17566 3.65533   -37.76635 1.000 22.05318 ? 185 PHE A O   1 
ATOM   1414 C  CB  . PHE A 1 185 ? -16.86499 1.40336   -36.83436 1.000 23.53263 ? 185 PHE A CB  1 
ATOM   1415 C  CG  . PHE A 1 185 ? -15.42472 1.03801   -37.04864 1.000 29.44343 ? 185 PHE A CG  1 
ATOM   1416 C  CD1 . PHE A 1 185 ? -15.08847 -0.08798  -37.78587 1.000 28.71388 ? 185 PHE A CD1 1 
ATOM   1417 C  CD2 . PHE A 1 185 ? -14.40811 1.85127   -36.57574 1.000 26.19998 ? 185 PHE A CD2 1 
ATOM   1418 C  CE1 . PHE A 1 185 ? -13.76443 -0.41378  -38.02591 1.000 26.05484 ? 185 PHE A CE1 1 
ATOM   1419 C  CE2 . PHE A 1 185 ? -13.08283 1.52494   -36.81010 1.000 23.83881 ? 185 PHE A CE2 1 
ATOM   1420 C  CZ  . PHE A 1 185 ? -12.76454 0.39023   -37.53365 1.000 25.82302 ? 185 PHE A CZ  1 
ATOM   1421 N  N   . VAL A 1 186 ? -19.89966 1.51728   -37.70031 1.000 20.46115 ? 186 VAL A N   1 
ATOM   1422 C  CA  . VAL A 1 186 ? -21.30346 1.83270   -37.45441 1.000 23.23511 ? 186 VAL A CA  1 
ATOM   1423 C  C   . VAL A 1 186 ? -21.80259 0.94954   -36.32021 1.000 24.09514 ? 186 VAL A C   1 
ATOM   1424 O  O   . VAL A 1 186 ? -21.28763 -0.15287  -36.09957 1.000 20.69241 ? 186 VAL A O   1 
ATOM   1425 C  CB  . VAL A 1 186 ? -22.18475 1.63894   -38.71714 1.000 20.98279 ? 186 VAL A CB  1 
ATOM   1426 C  CG1 . VAL A 1 186 ? -21.78007 2.60801   -39.80635 1.000 22.80597 ? 186 VAL A CG1 1 
ATOM   1427 C  CG2 . VAL A 1 186 ? -22.10638 0.19811   -39.21921 1.000 26.20117 ? 186 VAL A CG2 1 
ATOM   1428 N  N   . ASP A 1 187 ? -22.82510 1.43031   -35.59879 1.000 23.33169 ? 187 ASP A N   1 
ATOM   1429 C  CA  . ASP A 1 187 ? -23.36048 0.66910   -34.46231 1.000 22.96422 ? 187 ASP A CA  1 
ATOM   1430 C  C   . ASP A 1 187 ? -24.47730 -0.26629  -34.93607 1.000 28.59844 ? 187 ASP A C   1 
ATOM   1431 O  O   . ASP A 1 187 ? -25.66530 -0.09405  -34.65492 1.000 22.32713 ? 187 ASP A O   1 
ATOM   1432 C  CB  . ASP A 1 187 ? -23.81413 1.59404   -33.33287 1.000 22.04933 ? 187 ASP A CB  1 
ATOM   1433 C  CG  . ASP A 1 187 ? -24.72707 2.71863   -33.79664 1.000 21.25234 ? 187 ASP A CG  1 
ATOM   1434 O  OD1 . ASP A 1 187 ? -24.98801 2.83619   -35.00900 1.000 23.61888 ? 187 ASP A OD1 1 
ATOM   1435 O  OD2 . ASP A 1 187 ? -25.17359 3.50275   -32.93076 1.000 22.21794 ? 187 ASP A OD2 1 
ATOM   1436 N  N   . ARG A 1 188 ? -24.05614 -1.27231  -35.69658 1.000 28.58003 ? 188 ARG A N   1 
ATOM   1437 C  CA  . ARG A 1 188 ? -24.85264 -2.46843  -35.93557 1.000 29.25219 ? 188 ARG A CA  1 
ATOM   1438 C  C   . ARG A 1 188 ? -23.89362 -3.60880  -36.23975 1.000 30.06825 ? 188 ARG A C   1 
ATOM   1439 O  O   . ARG A 1 188 ? -22.73935 -3.38557  -36.62116 1.000 27.86335 ? 188 ARG A O   1 
ATOM   1440 C  CB  . ARG A 1 188 ? -25.87297 -2.28009  -37.06137 1.000 34.74772 ? 188 ARG A CB  1 
ATOM   1441 C  CG  . ARG A 1 188 ? -25.33752 -1.77694  -38.36317 1.000 28.82962 ? 188 ARG A CG  1 
ATOM   1442 C  CD  . ARG A 1 188 ? -26.49489 -1.57597  -39.34234 1.000 31.57267 ? 188 ARG A CD  1 
ATOM   1443 N  NE  . ARG A 1 188 ? -26.04462 -0.92259  -40.55490 1.000 30.08953 ? 188 ARG A NE  1 
ATOM   1444 C  CZ  . ARG A 1 188 ? -26.05765 -1.45332  -41.77332 1.000 31.55327 ? 188 ARG A CZ  1 
ATOM   1445 N  NH1 . ARG A 1 188 ? -26.61790 -2.63064  -42.02278 1.000 28.92764 ? 188 ARG A NH1 1 
ATOM   1446 N  NH2 . ARG A 1 188 ? -25.50033 -0.77835  -42.77064 1.000 26.12847 ? 188 ARG A NH2 1 
ATOM   1447 N  N   . GLN A 1 189 ? -24.38138 -4.83444  -36.05016 1.000 29.75375 ? 189 GLN A N   1 
ATOM   1448 C  CA  . GLN A 1 189 ? -23.52302 -6.02043  -36.05838 1.000 34.39063 ? 189 GLN A CA  1 
ATOM   1449 C  C   . GLN A 1 189 ? -23.29303 -6.59416  -37.44353 1.000 35.56231 ? 189 GLN A C   1 
ATOM   1450 O  O   . GLN A 1 189 ? -23.26765 -7.81687  -37.60591 1.000 38.78033 ? 189 GLN A O   1 
ATOM   1451 C  CB  . GLN A 1 189 ? -24.10810 -7.08064  -35.13759 1.000 36.43638 ? 189 GLN A CB  1 
ATOM   1452 C  CG  . GLN A 1 189 ? -24.13513 -6.65648  -33.68967 1.000 44.67206 ? 189 GLN A CG  1 
ATOM   1453 C  CD  . GLN A 1 189 ? -24.59635 -7.76490  -32.77880 1.000 49.02520 ? 189 GLN A CD  1 
ATOM   1454 O  OE1 . GLN A 1 189 ? -25.18880 -8.74574  -33.23009 1.000 54.08100 ? 189 GLN A OE1 1 
ATOM   1455 N  NE2 . GLN A 1 189 ? -24.32275 -7.62120  -31.48664 1.000 48.21309 ? 189 GLN A NE2 1 
ATOM   1456 N  N   . ILE A 1 190 ? -23.11237 -5.75549  -38.45691 1.000 31.60857 ? 190 ILE A N   1 
ATOM   1457 C  CA  . ILE A 1 190 ? -22.77291 -6.24505  -39.78633 1.000 33.91195 ? 190 ILE A CA  1 
ATOM   1458 C  C   . ILE A 1 190 ? -21.25813 -6.33917  -39.88465 1.000 37.13315 ? 190 ILE A C   1 
ATOM   1459 O  O   . ILE A 1 190 ? -20.53731 -5.84335  -39.00893 1.000 34.61478 ? 190 ILE A O   1 
ATOM   1460 C  CB  . ILE A 1 190 ? -23.36804 -5.34330  -40.88599 1.000 33.44443 ? 190 ILE A CB  1 
ATOM   1461 C  CG1 . ILE A 1 190 ? -23.08248 -3.86572  -40.60052 1.000 34.93746 ? 190 ILE A CG1 1 
ATOM   1462 C  CG2 . ILE A 1 190 ? -24.87916 -5.55758  -40.98175 1.000 34.31541 ? 190 ILE A CG2 1 
ATOM   1463 C  CD1 . ILE A 1 190 ? -21.81978 -3.33596  -41.20927 1.000 31.61248 ? 190 ILE A CD1 1 
ATOM   1464 N  N   . ALA A 1 191 ? -20.76527 -6.97468  -40.94614 1.000 37.22008 ? 191 ALA A N   1 
ATOM   1465 C  CA  . ALA A 1 191 ? -19.32654 -7.10276  -41.13351 1.000 35.59567 ? 191 ALA A CA  1 
ATOM   1466 C  C   . ALA A 1 191 ? -18.69421 -5.73367  -41.31961 1.000 38.21669 ? 191 ALA A C   1 
ATOM   1467 O  O   . ALA A 1 191 ? -19.18867 -4.90120  -42.08478 1.000 34.65033 ? 191 ALA A O   1 
ATOM   1468 C  CB  . ALA A 1 191 ? -19.01313 -7.99325  -42.33615 1.000 37.27411 ? 191 ALA A CB  1 
ATOM   1469 N  N   . GLN A 1 192 ? -17.60689 -5.49598  -40.59145 1.000 38.55372 ? 192 GLN A N   1 
ATOM   1470 C  CA  . GLN A 1 192 ? -16.81912 -4.28179  -40.77301 1.000 39.93364 ? 192 GLN A CA  1 
ATOM   1471 C  C   . GLN A 1 192 ? -15.43990 -4.55922  -40.19234 1.000 43.94009 ? 192 GLN A C   1 
ATOM   1472 O  O   . GLN A 1 192 ? -15.28978 -4.68128  -38.97366 1.000 46.60055 ? 192 GLN A O   1 
ATOM   1473 C  CB  . GLN A 1 192 ? -17.48425 -3.08164  -40.10428 1.000 41.16151 ? 192 GLN A CB  1 
ATOM   1474 C  CG  . GLN A 1 192 ? -18.12766 -3.37892  -38.75247 1.000 36.39115 ? 192 GLN A CG  1 
ATOM   1475 C  CD  . GLN A 1 192 ? -18.93698 -2.20613  -38.20931 1.000 31.15704 ? 192 GLN A CD  1 
ATOM   1476 O  OE1 . GLN A 1 192 ? -18.65697 -1.04517  -38.50751 1.000 27.19070 ? 192 GLN A OE1 1 
ATOM   1477 N  NE2 . GLN A 1 192 ? -19.94019 -2.50970  -37.39967 1.000 29.78370 ? 192 GLN A NE2 1 
ATOM   1478 N  N   . ALA A 1 193 ? -14.45041 -4.69969  -41.05685 1.000 42.73525 ? 193 ALA A N   1 
ATOM   1479 C  CA  . ALA A 1 193 ? -13.09007 -4.92616  -40.60371 1.000 43.75401 ? 193 ALA A CA  1 
ATOM   1480 C  C   . ALA A 1 193 ? -12.36298 -3.59577  -40.52087 1.000 40.14977 ? 193 ALA A C   1 
ATOM   1481 O  O   . ALA A 1 193 ? -12.64185 -2.66381  -41.28257 1.000 39.55456 ? 193 ALA A O   1 
ATOM   1482 C  CB  . ALA A 1 193 ? -12.34030 -5.88007  -41.53603 1.000 48.00413 ? 193 ALA A CB  1 
ATOM   1483 N  N   . ALA A 1 194 ? -11.44542 -3.50641  -39.56784 1.000 41.02467 ? 194 ALA A N   1 
ATOM   1484 C  CA  . ALA A 1 194 ? -10.60162 -2.33095  -39.47507 1.000 37.10621 ? 194 ALA A CA  1 
ATOM   1485 C  C   . ALA A 1 194 ? -9.45375  -2.43689  -40.47066 1.000 37.58493 ? 194 ALA A C   1 
ATOM   1486 O  O   . ALA A 1 194 ? -9.01751  -3.53263  -40.83208 1.000 34.81958 ? 194 ALA A O   1 
ATOM   1487 C  CB  . ALA A 1 194 ? -10.06542 -2.17190  -38.05717 1.000 31.95200 ? 194 ALA A CB  1 
ATOM   1488 N  N   . GLY A 1 195 ? -8.97490  -1.28313  -40.92433 1.000 33.76934 ? 195 GLY A N   1 
ATOM   1489 C  CA  . GLY A 1 195 ? -7.84735  -1.25753  -41.83026 1.000 36.31670 ? 195 GLY A CA  1 
ATOM   1490 C  C   . GLY A 1 195 ? -6.58278  -1.81032  -41.20034 1.000 37.10020 ? 195 GLY A C   1 
ATOM   1491 O  O   . GLY A 1 195 ? -6.56605  -2.16513  -40.01609 1.000 28.64128 ? 195 GLY A O   1 
ATOM   1492 N  N   . THR A 1 196 ? -5.51521  -1.89741  -41.98931 1.000 38.10400 ? 196 THR A N   1 
ATOM   1493 C  CA  A THR A 1 196 ? -4.24876  -2.39504  -41.46948 0.500 34.81429 ? 196 THR A CA  1 
ATOM   1494 C  CA  B THR A 1 196 ? -4.24625  -2.39114  -41.47537 0.500 34.81850 ? 196 THR A CA  1 
ATOM   1495 C  C   . THR A 1 196 ? -3.76567  -1.51795  -40.32312 1.000 29.65712 ? 196 THR A C   1 
ATOM   1496 O  O   . THR A 1 196 ? -3.68604  -0.29195  -40.44663 1.000 32.57467 ? 196 THR A O   1 
ATOM   1497 C  CB  A THR A 1 196 ? -3.19720  -2.44066  -42.57915 0.500 36.24192 ? 196 THR A CB  1 
ATOM   1498 C  CB  B THR A 1 196 ? -3.20726  -2.41791  -42.59652 0.500 36.23926 ? 196 THR A CB  1 
ATOM   1499 O  OG1 A THR A 1 196 ? -3.51721  -3.49226  -43.49616 0.500 38.38467 ? 196 THR A OG1 1 
ATOM   1500 O  OG1 B THR A 1 196 ? -3.16696  -1.13887  -43.24163 0.500 34.69626 ? 196 THR A OG1 1 
ATOM   1501 C  CG2 A THR A 1 196 ? -1.80280  -2.68480  -41.99531 0.500 32.83722 ? 196 THR A CG2 1 
ATOM   1502 C  CG2 B THR A 1 196 ? -3.56993  -3.47717  -43.62215 0.500 38.31899 ? 196 THR A CG2 1 
ATOM   1503 N  N   . ASP A 1 197 ? -3.46138  -2.14578  -39.19568 1.000 29.61007 ? 197 ASP A N   1 
ATOM   1504 C  CA  . ASP A 1 197 ? -2.92914  -1.39895  -38.06510 1.000 30.54162 ? 197 ASP A CA  1 
ATOM   1505 C  C   . ASP A 1 197 ? -1.45966  -1.10400  -38.34476 1.000 33.67691 ? 197 ASP A C   1 
ATOM   1506 O  O   . ASP A 1 197 ? -0.65292  -2.02926  -38.48658 1.000 36.30613 ? 197 ASP A O   1 
ATOM   1507 C  CB  . ASP A 1 197 ? -3.10468  -2.17117  -36.75792 1.000 31.65044 ? 197 ASP A CB  1 
ATOM   1508 C  CG  . ASP A 1 197 ? -2.49609  -1.44140  -35.55753 1.000 39.56205 ? 197 ASP A CG  1 
ATOM   1509 O  OD1 . ASP A 1 197 ? -2.72516  -0.21767  -35.42126 1.000 27.44668 ? 197 ASP A OD1 1 
ATOM   1510 O  OD2 . ASP A 1 197 ? -1.78468  -2.09226  -34.75286 1.000 46.11677 ? 197 ASP A OD2 1 
ATOM   1511 N  N   . THR A 1 198 ? -1.12750  0.17500   -38.47209 1.000 28.15809 ? 198 THR A N   1 
ATOM   1512 C  CA  . THR A 1 198 ? 0.23986   0.61640   -38.68898 1.000 27.61848 ? 198 THR A CA  1 
ATOM   1513 C  C   . THR A 1 198 ? 0.82433   1.18630   -37.39649 1.000 26.46812 ? 198 THR A C   1 
ATOM   1514 O  O   . THR A 1 198 ? 0.10505   1.46640   -36.43400 1.000 24.47311 ? 198 THR A O   1 
ATOM   1515 C  CB  . THR A 1 198 ? 0.29445   1.65642   -39.80775 1.000 24.47967 ? 198 THR A CB  1 
ATOM   1516 O  OG1 . THR A 1 198 ? -0.60020  2.73098   -39.50992 1.000 25.80864 ? 198 THR A OG1 1 
ATOM   1517 C  CG2 . THR A 1 198 ? -0.11606  1.04061   -41.13768 1.000 27.61878 ? 198 THR A CG2 1 
ATOM   1518 N  N   . THR A 1 199 ? 2.14916   1.33272   -37.38594 1.000 20.55243 ? 199 THR A N   1 
ATOM   1519 C  CA  . THR A 1 199 ? 2.86337   1.90173   -36.25200 1.000 16.60590 ? 199 THR A CA  1 
ATOM   1520 C  C   . THR A 1 199 ? 2.90031   3.42035   -36.34111 1.000 18.26335 ? 199 THR A C   1 
ATOM   1521 O  O   . THR A 1 199 ? 3.11147   3.98612   -37.41816 1.000 19.18794 ? 199 THR A O   1 
ATOM   1522 C  CB  . THR A 1 199 ? 4.29440   1.36011   -36.19799 1.000 21.41512 ? 199 THR A CB  1 
ATOM   1523 O  OG1 . THR A 1 199 ? 4.25949   -0.06501  -36.08757 1.000 23.70080 ? 199 THR A OG1 1 
ATOM   1524 C  CG2 . THR A 1 199 ? 5.04834   1.93533   -34.99347 1.000 15.72338 ? 199 THR A CG2 1 
ATOM   1525 N  N   . ILE A 1 200 ? 2.72466   4.07868   -35.19136 1.000 14.81434 ? 200 ILE A N   1 
ATOM   1526 C  CA  . ILE A 1 200 ? 2.69071   5.53615   -35.11509 1.000 14.88232 ? 200 ILE A CA  1 
ATOM   1527 C  C   . ILE A 1 200 ? 4.12149   6.06061   -35.04525 1.000 20.77183 ? 200 ILE A C   1 
ATOM   1528 O  O   . ILE A 1 200 ? 4.71384   6.17679   -33.95680 1.000 16.20618 ? 200 ILE A O   1 
ATOM   1529 C  CB  . ILE A 1 200 ? 1.85645   6.01283   -33.91202 1.000 16.67513 ? 200 ILE A CB  1 
ATOM   1530 C  CG1 . ILE A 1 200 ? 0.46647   5.34994   -33.95727 1.000 16.50627 ? 200 ILE A CG1 1 
ATOM   1531 C  CG2 . ILE A 1 200 ? 1.72530   7.52363   -33.91849 1.000 16.97137 ? 200 ILE A CG2 1 
ATOM   1532 C  CD1 . ILE A 1 200 ? -0.23373  5.34045   -32.59698 1.000 18.73682 ? 200 ILE A CD1 1 
ATOM   1533 N  N   . THR A 1 201 ? 4.65829   6.41579   -36.21338 1.000 17.06349 ? 201 THR A N   1 
ATOM   1534 C  CA  . THR A 1 201 ? 6.08711   6.69055   -36.35159 1.000 17.93770 ? 201 THR A CA  1 
ATOM   1535 C  C   . THR A 1 201 ? 6.51779   7.86718   -35.48424 1.000 18.03664 ? 201 THR A C   1 
ATOM   1536 O  O   . THR A 1 201 ? 7.54615   7.80567   -34.79691 1.000 20.07415 ? 201 THR A O   1 
ATOM   1537 C  CB  . THR A 1 201 ? 6.40638   6.95957   -37.82805 1.000 20.24469 ? 201 THR A CB  1 
ATOM   1538 O  OG1 . THR A 1 201 ? 5.88899   5.88722   -38.61868 1.000 20.61730 ? 201 THR A OG1 1 
ATOM   1539 C  CG2 . THR A 1 201 ? 7.91196   7.07144   -38.05317 1.000 16.31979 ? 201 THR A CG2 1 
ATOM   1540 N  N   . VAL A 1 202 ? 5.74614   8.95784   -35.50538 1.000 15.87533 ? 202 VAL A N   1 
ATOM   1541 C  CA  . VAL A 1 202 ? 6.13995   10.13348  -34.73601 1.000 17.23430 ? 202 VAL A CA  1 
ATOM   1542 C  C   . VAL A 1 202 ? 6.23105   9.79372   -33.24922 1.000 18.72021 ? 202 VAL A C   1 
ATOM   1543 O  O   . VAL A 1 202 ? 7.10704   10.30174  -32.54303 1.000 17.11842 ? 202 VAL A O   1 
ATOM   1544 C  CB  . VAL A 1 202 ? 5.18062   11.31298  -35.01392 1.000 19.12372 ? 202 VAL A CB  1 
ATOM   1545 C  CG1 . VAL A 1 202 ? 3.76917   11.00715  -34.53005 1.000 20.35614 ? 202 VAL A CG1 1 
ATOM   1546 C  CG2 . VAL A 1 202 ? 5.70196   12.59516  -34.36971 1.000 23.50478 ? 202 VAL A CG2 1 
ATOM   1547 N  N   . ASN A 1 203 ? 5.37887   8.88580   -32.76548 1.000 17.67886 ? 203 ASN A N   1 
ATOM   1548 C  CA  . ASN A 1 203 ? 5.42528   8.49877   -31.35395 1.000 19.24231 ? 203 ASN A CA  1 
ATOM   1549 C  C   . ASN A 1 203 ? 6.65732   7.65050   -31.04885 1.000 17.95478 ? 203 ASN A C   1 
ATOM   1550 O  O   . ASN A 1 203 ? 7.28890   7.81865   -29.99666 1.000 19.02718 ? 203 ASN A O   1 
ATOM   1551 C  CB  . ASN A 1 203 ? 4.14831   7.73591   -30.97245 1.000 17.42921 ? 203 ASN A CB  1 
ATOM   1552 C  CG  . ASN A 1 203 ? 2.92572   8.63868   -30.88286 1.000 18.42133 ? 203 ASN A CG  1 
ATOM   1553 O  OD1 . ASN A 1 203 ? 2.99554   9.83436   -31.17525 1.000 16.45715 ? 203 ASN A OD1 1 
ATOM   1554 N  ND2 . ASN A 1 203 ? 1.79375   8.06624   -30.47561 1.000 16.91622 ? 203 ASN A ND2 1 
ATOM   1555 N  N   . VAL A 1 204 ? 6.98777   6.70734   -31.93376 1.000 16.50316 ? 204 VAL A N   1 
ATOM   1556 C  CA  . VAL A 1 204 ? 8.19185   5.89483   -31.74996 1.000 17.26725 ? 204 VAL A CA  1 
ATOM   1557 C  C   . VAL A 1 204 ? 9.42093   6.78759   -31.65020 1.000 19.53175 ? 204 VAL A C   1 
ATOM   1558 O  O   . VAL A 1 204 ? 10.28387  6.59296   -30.78405 1.000 20.05142 ? 204 VAL A O   1 
ATOM   1559 C  CB  . VAL A 1 204 ? 8.33598   4.87565   -32.89740 1.000 21.68995 ? 204 VAL A CB  1 
ATOM   1560 C  CG1 . VAL A 1 204 ? 9.71628   4.20820   -32.86758 1.000 19.74550 ? 204 VAL A CG1 1 
ATOM   1561 C  CG2 . VAL A 1 204 ? 7.22733   3.82451   -32.83272 1.000 16.60356 ? 204 VAL A CG2 1 
ATOM   1562 N  N   . LEU A 1 205 ? 9.51782   7.78124   -32.53196 1.000 17.87343 ? 205 LEU A N   1 
ATOM   1563 C  CA  . LEU A 1 205 ? 10.67535  8.66761   -32.51167 1.000 21.48182 ? 205 LEU A CA  1 
ATOM   1564 C  C   . LEU A 1 205 ? 10.73679  9.43565   -31.20367 1.000 20.60940 ? 205 LEU A C   1 
ATOM   1565 O  O   . LEU A 1 205 ? 11.81289  9.58588   -30.61488 1.000 20.64874 ? 205 LEU A O   1 
ATOM   1566 C  CB  . LEU A 1 205 ? 10.63113  9.62496   -33.70489 1.000 19.13172 ? 205 LEU A CB  1 
ATOM   1567 C  CG  . LEU A 1 205 ? 10.93076  9.03596   -35.09102 1.000 18.65875 ? 205 LEU A CG  1 
ATOM   1568 C  CD1 . LEU A 1 205 ? 10.55118  10.03076  -36.16077 1.000 20.65594 ? 205 LEU A CD1 1 
ATOM   1569 C  CD2 . LEU A 1 205 ? 12.42053  8.65588   -35.22539 1.000 16.28856 ? 205 LEU A CD2 1 
ATOM   1570 N  N   . ALA A 1 206 ? 9.58068   9.90929   -30.72554 1.000 22.33316 ? 206 ALA A N   1 
ATOM   1571 C  CA  . ALA A 1 206 ? 9.53210   10.64677  -29.47096 1.000 20.71911 ? 206 ALA A CA  1 
ATOM   1572 C  C   . ALA A 1 206 ? 9.99041   9.77413   -28.31162 1.000 21.72217 ? 206 ALA A C   1 
ATOM   1573 O  O   . ALA A 1 206 ? 10.71934  10.23198  -27.42789 1.000 20.38671 ? 206 ALA A O   1 
ATOM   1574 C  CB  . ALA A 1 206 ? 8.11698   11.16787  -29.22473 1.000 19.89697 ? 206 ALA A CB  1 
ATOM   1575 N  N   . TRP A 1 207 ? 9.58543   8.50702   -28.32083 1.000 19.12318 ? 207 TRP A N   1 
ATOM   1576 C  CA  . TRP A 1 207 ? 9.99706   7.55482   -27.30085 1.000 20.50471 ? 207 TRP A CA  1 
ATOM   1577 C  C   . TRP A 1 207 ? 11.49725  7.26416   -27.36228 1.000 26.56992 ? 207 TRP A C   1 
ATOM   1578 O  O   . TRP A 1 207 ? 12.12605  7.03568   -26.32014 1.000 24.28256 ? 207 TRP A O   1 
ATOM   1579 C  CB  . TRP A 1 207 ? 9.15986   6.29049   -27.48487 1.000 22.13383 ? 207 TRP A CB  1 
ATOM   1580 C  CG  . TRP A 1 207 ? 9.50778   5.08873   -26.66177 1.000 22.27805 ? 207 TRP A CG  1 
ATOM   1581 C  CD1 . TRP A 1 207 ? 9.16213   4.84579   -25.35603 1.000 24.08497 ? 207 TRP A CD1 1 
ATOM   1582 C  CD2 . TRP A 1 207 ? 10.19543  3.92196   -27.11634 1.000 20.93889 ? 207 TRP A CD2 1 
ATOM   1583 N  NE1 . TRP A 1 207 ? 9.62088   3.61010   -24.97134 1.000 25.04385 ? 207 TRP A NE1 1 
ATOM   1584 C  CE2 . TRP A 1 207 ? 10.25655  3.02280   -26.03397 1.000 24.67379 ? 207 TRP A CE2 1 
ATOM   1585 C  CE3 . TRP A 1 207 ? 10.77677  3.55358   -28.33463 1.000 23.99114 ? 207 TRP A CE3 1 
ATOM   1586 C  CZ2 . TRP A 1 207 ? 10.88230  1.78329   -26.13080 1.000 27.85917 ? 207 TRP A CZ2 1 
ATOM   1587 C  CZ3 . TRP A 1 207 ? 11.38988  2.31859   -28.43159 1.000 22.76036 ? 207 TRP A CZ3 1 
ATOM   1588 C  CH2 . TRP A 1 207 ? 11.44058  1.44983   -27.33395 1.000 23.19644 ? 207 TRP A CH2 1 
ATOM   1589 N  N   . LEU A 1 208 ? 12.08717  7.25836   -28.56577 1.000 21.43131 ? 208 LEU A N   1 
ATOM   1590 C  CA  . LEU A 1 208 ? 13.53750  7.11401   -28.67483 1.000 20.47554 ? 208 LEU A CA  1 
ATOM   1591 C  C   . LEU A 1 208 ? 14.24747  8.33490   -28.10289 1.000 21.70798 ? 208 LEU A C   1 
ATOM   1592 O  O   . LEU A 1 208 ? 15.30402  8.20682   -27.47623 1.000 21.70936 ? 208 LEU A O   1 
ATOM   1593 C  CB  . LEU A 1 208 ? 13.94800  6.89097   -30.13811 1.000 21.66612 ? 208 LEU A CB  1 
ATOM   1594 C  CG  . LEU A 1 208 ? 13.59028  5.54247   -30.77493 1.000 17.94180 ? 208 LEU A CG  1 
ATOM   1595 C  CD1 . LEU A 1 208 ? 13.90119  5.51728   -32.26729 1.000 17.12209 ? 208 LEU A CD1 1 
ATOM   1596 C  CD2 . LEU A 1 208 ? 14.28828  4.38718   -30.07728 1.000 18.21892 ? 208 LEU A CD2 1 
ATOM   1597 N  N   . TYR A 1 209 ? 13.68219  9.52916   -28.30984 1.000 20.82047 ? 209 TYR A N   1 
ATOM   1598 C  CA  . TYR A 1 209 ? 14.20668  10.71513  -27.63765 1.000 24.51972 ? 209 TYR A CA  1 
ATOM   1599 C  C   . TYR A 1 209 ? 14.10569  10.57975  -26.12259 1.000 26.38682 ? 209 TYR A C   1 
ATOM   1600 O  O   . TYR A 1 209 ? 15.01688  10.98785  -25.39326 1.000 26.27760 ? 209 TYR A O   1 
ATOM   1601 C  CB  . TYR A 1 209 ? 13.47318  11.97014  -28.11297 1.000 22.96588 ? 209 TYR A CB  1 
ATOM   1602 C  CG  . TYR A 1 209 ? 14.02343  12.54153  -29.39045 1.000 25.03057 ? 209 TYR A CG  1 
ATOM   1603 C  CD1 . TYR A 1 209 ? 15.29713  13.10000  -29.42817 1.000 24.38669 ? 209 TYR A CD1 1 
ATOM   1604 C  CD2 . TYR A 1 209 ? 13.28025  12.51562  -30.56484 1.000 25.94952 ? 209 TYR A CD2 1 
ATOM   1605 C  CE1 . TYR A 1 209 ? 15.80737  13.61900  -30.58287 1.000 22.91335 ? 209 TYR A CE1 1 
ATOM   1606 C  CE2 . TYR A 1 209 ? 13.78468  13.03215  -31.73561 1.000 23.58658 ? 209 TYR A CE2 1 
ATOM   1607 C  CZ  . TYR A 1 209 ? 15.05542  13.57992  -31.74014 1.000 24.74540 ? 209 TYR A CZ  1 
ATOM   1608 O  OH  . TYR A 1 209 ? 15.56245  14.10494  -32.90068 1.000 21.57738 ? 209 TYR A OH  1 
ATOM   1609 N  N   . ALA A 1 210 ? 13.00058  10.01387  -25.62881 1.000 27.80717 ? 210 ALA A N   1 
ATOM   1610 C  CA  . ALA A 1 210 ? 12.87995  9.75873   -24.19583 1.000 27.60669 ? 210 ALA A CA  1 
ATOM   1611 C  C   . ALA A 1 210 ? 13.96422  8.80370   -23.71217 1.000 28.62798 ? 210 ALA A C   1 
ATOM   1612 O  O   . ALA A 1 210 ? 14.45150  8.92436   -22.58203 1.000 28.94787 ? 210 ALA A O   1 
ATOM   1613 C  CB  . ALA A 1 210 ? 11.50369  9.19107   -23.87041 1.000 23.42121 ? 210 ALA A CB  1 
ATOM   1614 N  N   . ALA A 1 211 ? 14.34118  7.83487   -24.54501 1.000 24.91346 ? 211 ALA A N   1 
ATOM   1615 C  CA  . ALA A 1 211 ? 15.38102  6.89890   -24.13592 1.000 26.05516 ? 211 ALA A CA  1 
ATOM   1616 C  C   . ALA A 1 211 ? 16.72771  7.60067   -24.00921 1.000 27.90418 ? 211 ALA A C   1 
ATOM   1617 O  O   . ALA A 1 211 ? 17.47697  7.35301   -23.05467 1.000 32.92499 ? 211 ALA A O   1 
ATOM   1618 C  CB  . ALA A 1 211 ? 15.46274  5.74105   -25.12559 1.000 28.37839 ? 211 ALA A CB  1 
ATOM   1619 N  N   . VAL A 1 212 ? 17.04318  8.49393   -24.94828 1.000 26.27368 ? 212 VAL A N   1 
ATOM   1620 C  CA  . VAL A 1 212 ? 18.29181  9.24621   -24.85981 1.000 32.33034 ? 212 VAL A CA  1 
ATOM   1621 C  C   . VAL A 1 212 ? 18.26669  10.17031  -23.65022 1.000 33.75839 ? 212 VAL A C   1 
ATOM   1622 O  O   . VAL A 1 212 ? 19.26195  10.29964  -22.92624 1.000 30.89124 ? 212 VAL A O   1 
ATOM   1623 C  CB  . VAL A 1 212 ? 18.54483  10.02620  -26.16277 1.000 29.16258 ? 212 VAL A CB  1 
ATOM   1624 C  CG1 . VAL A 1 212 ? 19.75025  10.95048  -26.00248 1.000 26.47828 ? 212 VAL A CG1 1 
ATOM   1625 C  CG2 . VAL A 1 212 ? 18.74610  9.06616   -27.33141 1.000 24.24755 ? 212 VAL A CG2 1 
ATOM   1626 N  N   . ILE A 1 213 ? 17.12713  10.82187  -23.41113 1.000 31.92668 ? 213 ILE A N   1 
ATOM   1627 C  CA  . ILE A 1 213 ? 16.97331  11.66573  -22.22823 1.000 32.55792 ? 213 ILE A CA  1 
ATOM   1628 C  C   . ILE A 1 213 ? 17.27438  10.87406  -20.96135 1.000 32.39456 ? 213 ILE A C   1 
ATOM   1629 O  O   . ILE A 1 213 ? 17.95466  11.36310  -20.05268 1.000 31.17672 ? 213 ILE A O   1 
ATOM   1630 C  CB  . ILE A 1 213 ? 15.55698  12.27259  -22.20046 1.000 31.57046 ? 213 ILE A CB  1 
ATOM   1631 C  CG1 . ILE A 1 213 ? 15.46118  13.42784  -23.20066 1.000 31.02145 ? 213 ILE A CG1 1 
ATOM   1632 C  CG2 . ILE A 1 213 ? 15.17281  12.69687  -20.78011 1.000 35.74082 ? 213 ILE A CG2 1 
ATOM   1633 C  CD1 . ILE A 1 213 ? 14.03397  13.94279  -23.43742 1.000 32.13276 ? 213 ILE A CD1 1 
ATOM   1634 N  N   . ASN A 1 214 ? 16.78330  9.64118   -20.88392 1.000 30.52607 ? 214 ASN A N   1 
ATOM   1635 C  CA  . ASN A 1 214 ? 17.00410  8.79587   -19.72398 1.000 30.83201 ? 214 ASN A CA  1 
ATOM   1636 C  C   . ASN A 1 214 ? 18.33449  8.04779   -19.77487 1.000 33.05170 ? 214 ASN A C   1 
ATOM   1637 O  O   . ASN A 1 214 ? 18.52833  7.12239   -18.98686 1.000 33.15799 ? 214 ASN A O   1 
ATOM   1638 C  CB  . ASN A 1 214 ? 15.84378  7.80813   -19.56590 1.000 32.96887 ? 214 ASN A CB  1 
ATOM   1639 C  CG  . ASN A 1 214 ? 14.60697  8.45145   -18.93995 1.000 44.69387 ? 214 ASN A CG  1 
ATOM   1640 O  OD1 . ASN A 1 214 ? 14.46002  8.48262   -17.71436 1.000 46.24759 ? 214 ASN A OD1 1 
ATOM   1641 N  ND2 . ASN A 1 214 ? 13.71227  8.96568   -19.78141 1.000 41.97783 ? 214 ASN A ND2 1 
ATOM   1642 N  N   . GLY A 1 215 ? 19.23678  8.40968   -20.68164 1.000 32.97426 ? 215 GLY A N   1 
ATOM   1643 C  CA  . GLY A 1 215 ? 20.60639  7.93718   -20.63690 1.000 34.25674 ? 215 GLY A CA  1 
ATOM   1644 C  C   . GLY A 1 215 ? 20.97109  6.76673   -21.52637 1.000 35.89345 ? 215 GLY A C   1 
ATOM   1645 O  O   . GLY A 1 215 ? 22.06672  6.21867   -21.36838 1.000 38.69085 ? 215 GLY A O   1 
ATOM   1646 N  N   . ASP A 1 216 ? 20.10857  6.36522   -22.45216 1.000 30.51961 ? 216 ASP A N   1 
ATOM   1647 C  CA  . ASP A 1 216 ? 20.35501  5.19655   -23.28762 1.000 31.37551 ? 216 ASP A CA  1 
ATOM   1648 C  C   . ASP A 1 216 ? 20.67114  5.66202   -24.70323 1.000 32.75405 ? 216 ASP A C   1 
ATOM   1649 O  O   . ASP A 1 216 ? 19.84741  6.33254   -25.33723 1.000 32.03191 ? 216 ASP A O   1 
ATOM   1650 C  CB  . ASP A 1 216 ? 19.14793  4.25790   -23.27355 1.000 33.64418 ? 216 ASP A CB  1 
ATOM   1651 C  CG  . ASP A 1 216 ? 19.54285  2.80427   -23.37323 1.000 39.92821 ? 216 ASP A CG  1 
ATOM   1652 O  OD1 . ASP A 1 216 ? 20.72187  2.54480   -23.71317 1.000 41.74063 ? 216 ASP A OD1 1 
ATOM   1653 O  OD2 . ASP A 1 216 ? 18.68286  1.92616   -23.10363 1.000 37.69629 ? 216 ASP A OD2 1 
ATOM   1654 N  N   . ARG A 1 217 ? 21.86243  5.30455   -25.19737 1.000 29.00948 ? 217 ARG A N   1 
ATOM   1655 C  CA  . ARG A 1 217 ? 22.32780  5.76559   -26.49730 1.000 23.41198 ? 217 ARG A CA  1 
ATOM   1656 C  C   . ARG A 1 217 ? 22.75856  4.63443   -27.42302 1.000 24.79609 ? 217 ARG A C   1 
ATOM   1657 O  O   . ARG A 1 217 ? 23.27795  4.91633   -28.50950 1.000 20.42654 ? 217 ARG A O   1 
ATOM   1658 C  CB  . ARG A 1 217 ? 23.49846  6.74481   -26.33236 1.000 30.26516 ? 217 ARG A CB  1 
ATOM   1659 C  CG  . ARG A 1 217 ? 23.14870  8.04664   -25.63538 1.000 30.80754 ? 217 ARG A CG  1 
ATOM   1660 C  CD  . ARG A 1 217 ? 24.34878  8.95859   -25.56976 1.000 33.33929 ? 217 ARG A CD  1 
ATOM   1661 N  NE  . ARG A 1 217 ? 24.98811  9.09276   -26.87254 1.000 28.27608 ? 217 ARG A NE  1 
ATOM   1662 C  CZ  . ARG A 1 217 ? 24.87434  10.14964  -27.66785 1.000 36.69627 ? 217 ARG A CZ  1 
ATOM   1663 N  NH1 . ARG A 1 217 ? 24.18555  11.21761  -27.30349 1.000 32.27044 ? 217 ARG A NH1 1 
ATOM   1664 N  NH2 . ARG A 1 217 ? 25.46707  10.13231  -28.86346 1.000 33.90115 ? 217 ARG A NH2 1 
ATOM   1665 N  N   . TRP A 1 218 ? 22.55237  3.37071   -27.03717 1.000 23.21581 ? 218 TRP A N   1 
ATOM   1666 C  CA  . TRP A 1 218 ? 23.18631  2.26859   -27.75466 1.000 21.40195 ? 218 TRP A CA  1 
ATOM   1667 C  C   . TRP A 1 218 ? 22.70265  2.13014   -29.19123 1.000 25.18141 ? 218 TRP A C   1 
ATOM   1668 O  O   . TRP A 1 218 ? 23.40579  1.51896   -30.00399 1.000 22.22410 ? 218 TRP A O   1 
ATOM   1669 C  CB  . TRP A 1 218 ? 22.97153  0.93766   -27.02688 1.000 22.14244 ? 218 TRP A CB  1 
ATOM   1670 C  CG  . TRP A 1 218 ? 21.54673  0.43106   -26.97846 1.000 25.06377 ? 218 TRP A CG  1 
ATOM   1671 C  CD1 . TRP A 1 218 ? 20.67580  0.53210   -25.92816 1.000 24.98247 ? 218 TRP A CD1 1 
ATOM   1672 C  CD2 . TRP A 1 218 ? 20.84932  -0.29149  -28.00348 1.000 25.88819 ? 218 TRP A CD2 1 
ATOM   1673 N  NE1 . TRP A 1 218 ? 19.47764  -0.06764  -26.24404 1.000 24.55522 ? 218 TRP A NE1 1 
ATOM   1674 C  CE2 . TRP A 1 218 ? 19.55692  -0.57743  -27.51084 1.000 25.52182 ? 218 TRP A CE2 1 
ATOM   1675 C  CE3 . TRP A 1 218 ? 21.18553  -0.71549  -29.29233 1.000 24.08183 ? 218 TRP A CE3 1 
ATOM   1676 C  CZ2 . TRP A 1 218 ? 18.61014  -1.26757  -28.26017 1.000 25.49458 ? 218 TRP A CZ2 1 
ATOM   1677 C  CZ3 . TRP A 1 218 ? 20.24145  -1.39500  -30.03455 1.000 25.01606 ? 218 TRP A CZ3 1 
ATOM   1678 C  CH2 . TRP A 1 218 ? 18.96980  -1.66555  -29.51656 1.000 27.13740 ? 218 TRP A CH2 1 
ATOM   1679 N  N   . PHE A 1 219 ? 21.52842  2.67605   -29.51674 1.000 20.25897 ? 219 PHE A N   1 
ATOM   1680 C  CA  . PHE A 1 219 ? 20.89255  2.48180   -30.81248 1.000 22.70817 ? 219 PHE A CA  1 
ATOM   1681 C  C   . PHE A 1 219 ? 21.19209  3.59415   -31.80738 1.000 20.98931 ? 219 PHE A C   1 
ATOM   1682 O  O   . PHE A 1 219 ? 20.78535  3.48860   -32.97082 1.000 23.89929 ? 219 PHE A O   1 
ATOM   1683 C  CB  . PHE A 1 219 ? 19.36935  2.36911   -30.62783 1.000 19.34107 ? 219 PHE A CB  1 
ATOM   1684 C  CG  . PHE A 1 219 ? 18.81090  3.42282   -29.72692 1.000 18.39206 ? 219 PHE A CG  1 
ATOM   1685 C  CD1 . PHE A 1 219 ? 18.47084  4.66739   -30.22760 1.000 19.11932 ? 219 PHE A CD1 1 
ATOM   1686 C  CD2 . PHE A 1 219 ? 18.67781  3.18973   -28.36313 1.000 24.18307 ? 219 PHE A CD2 1 
ATOM   1687 C  CE1 . PHE A 1 219 ? 17.98366  5.65669   -29.38992 1.000 20.67090 ? 219 PHE A CE1 1 
ATOM   1688 C  CE2 . PHE A 1 219 ? 18.19094  4.17366   -27.52346 1.000 20.09878 ? 219 PHE A CE2 1 
ATOM   1689 C  CZ  . PHE A 1 219 ? 17.84492  5.40842   -28.04348 1.000 20.39527 ? 219 PHE A CZ  1 
ATOM   1690 N  N   . LEU A 1 220 ? 21.85155  4.66466   -31.38138 1.000 21.43973 ? 220 LEU A N   1 
ATOM   1691 C  CA  . LEU A 1 220 ? 22.21458  5.72125   -32.31237 1.000 23.17078 ? 220 LEU A CA  1 
ATOM   1692 C  C   . LEU A 1 220 ? 23.26891  5.21860   -33.29621 1.000 24.81858 ? 220 LEU A C   1 
ATOM   1693 O  O   . LEU A 1 220 ? 23.90428  4.17866   -33.08823 1.000 24.03415 ? 220 LEU A O   1 
ATOM   1694 C  CB  . LEU A 1 220 ? 22.73441  6.93887   -31.55874 1.000 22.61709 ? 220 LEU A CB  1 
ATOM   1695 C  CG  . LEU A 1 220 ? 21.78388  7.48866   -30.49960 1.000 24.45185 ? 220 LEU A CG  1 
ATOM   1696 C  CD1 . LEU A 1 220 ? 22.42656  8.65377   -29.76487 1.000 30.35435 ? 220 LEU A CD1 1 
ATOM   1697 C  CD2 . LEU A 1 220 ? 20.47503  7.91568   -31.15603 1.000 24.95589 ? 220 LEU A CD2 1 
ATOM   1698 N  N   . ASN A 1 221 ? 23.44815  5.96691   -34.38795 1.000 22.81493 ? 221 ASN A N   1 
ATOM   1699 C  CA  . ASN A 1 221 ? 24.49568  5.65573   -35.35182 1.000 20.33135 ? 221 ASN A CA  1 
ATOM   1700 C  C   . ASN A 1 221 ? 24.97499  6.95032   -35.99541 1.000 24.87420 ? 221 ASN A C   1 
ATOM   1701 O  O   . ASN A 1 221 ? 24.51646  8.04457   -35.65933 1.000 22.45384 ? 221 ASN A O   1 
ATOM   1702 C  CB  . ASN A 1 221 ? 24.01727  4.63130   -36.39555 1.000 19.02562 ? 221 ASN A CB  1 
ATOM   1703 C  CG  . ASN A 1 221 ? 22.93239  5.17347   -37.32748 1.000 21.73288 ? 221 ASN A CG  1 
ATOM   1704 O  OD1 . ASN A 1 221 ? 22.75510  6.38170   -37.49165 1.000 21.65499 ? 221 ASN A OD1 1 
ATOM   1705 N  ND2 . ASN A 1 221 ? 22.20505  4.26007   -37.95794 1.000 22.45502 ? 221 ASN A ND2 1 
ATOM   1706 N  N   . ARG A 1 222 ? 25.88415  6.81392   -36.95696 1.000 21.97771 ? 222 ARG A N   1 
ATOM   1707 C  CA  . ARG A 1 222 ? 26.53182  7.95353   -37.58493 1.000 21.43783 ? 222 ARG A CA  1 
ATOM   1708 C  C   . ARG A 1 222 ? 25.84123  8.38068   -38.87307 1.000 27.05343 ? 222 ARG A C   1 
ATOM   1709 O  O   . ARG A 1 222 ? 26.36868  9.23521   -39.59144 1.000 29.06331 ? 222 ARG A O   1 
ATOM   1710 C  CB  . ARG A 1 222 ? 28.00607  7.62769   -37.85290 1.000 25.37620 ? 222 ARG A CB  1 
ATOM   1711 N  N   . PHE A 1 223 ? 24.67984  7.80744   -39.18147 1.000 20.53492 ? 223 PHE A N   1 
ATOM   1712 C  CA  . PHE A 1 223 ? 23.97436  8.08537   -40.41921 1.000 24.58097 ? 223 PHE A CA  1 
ATOM   1713 C  C   . PHE A 1 223 ? 22.93667  9.18687   -40.23090 1.000 25.36576 ? 223 PHE A C   1 
ATOM   1714 O  O   . PHE A 1 223 ? 22.48038  9.47397   -39.12150 1.000 26.07951 ? 223 PHE A O   1 
ATOM   1715 C  CB  . PHE A 1 223 ? 23.27714  6.82636   -40.94974 1.000 25.67746 ? 223 PHE A CB  1 
ATOM   1716 C  CG  . PHE A 1 223 ? 24.18777  5.88516   -41.68998 1.000 28.13775 ? 223 PHE A CG  1 
ATOM   1717 C  CD1 . PHE A 1 223 ? 24.99194  4.99851   -41.00361 1.000 26.62605 ? 223 PHE A CD1 1 
ATOM   1718 C  CD2 . PHE A 1 223 ? 24.21175  5.86928   -43.07493 1.000 30.42284 ? 223 PHE A CD2 1 
ATOM   1719 C  CE1 . PHE A 1 223 ? 25.83414  4.12518   -41.68178 1.000 27.30192 ? 223 PHE A CE1 1 
ATOM   1720 C  CE2 . PHE A 1 223 ? 25.04099  4.99423   -43.76337 1.000 33.34660 ? 223 PHE A CE2 1 
ATOM   1721 C  CZ  . PHE A 1 223 ? 25.86203  4.12702   -43.06100 1.000 27.09616 ? 223 PHE A CZ  1 
ATOM   1722 N  N   . THR A 1 224 ? 22.56949  9.80235   -41.34742 1.000 23.93340 ? 224 THR A N   1 
ATOM   1723 C  CA  . THR A 1 224 ? 21.37837  10.62618  -41.44919 1.000 25.17720 ? 224 THR A CA  1 
ATOM   1724 C  C   . THR A 1 224 ? 20.56023  10.10869  -42.61894 1.000 21.92841 ? 224 THR A C   1 
ATOM   1725 O  O   . THR A 1 224 ? 20.92354  9.12329   -43.27348 1.000 25.56388 ? 224 THR A O   1 
ATOM   1726 C  CB  . THR A 1 224 ? 21.71377  12.11345  -41.62637 1.000 30.75467 ? 224 THR A CB  1 
ATOM   1727 O  OG1 . THR A 1 224 ? 20.53282  12.89727  -41.39396 1.000 27.37162 ? 224 THR A OG1 1 
ATOM   1728 C  CG2 . THR A 1 224 ? 22.25573  12.39138  -43.04179 1.000 25.45101 ? 224 THR A CG2 1 
ATOM   1729 N  N   . THR A 1 225 ? 19.44287  10.77856  -42.88408 1.000 21.89137 ? 225 THR A N   1 
ATOM   1730 C  CA  . THR A 1 225 ? 18.55449  10.36598  -43.95473 1.000 19.53388 ? 225 THR A CA  1 
ATOM   1731 C  C   . THR A 1 225 ? 17.76960  11.57727  -44.41831 1.000 21.26600 ? 225 THR A C   1 
ATOM   1732 O  O   . THR A 1 225 ? 17.60702  12.55178  -43.68164 1.000 24.13447 ? 225 THR A O   1 
ATOM   1733 C  CB  . THR A 1 225 ? 17.59508  9.26571   -43.49622 1.000 23.73398 ? 225 THR A CB  1 
ATOM   1734 O  OG1 . THR A 1 225 ? 16.76180  8.85654   -44.59124 1.000 20.84480 ? 225 THR A OG1 1 
ATOM   1735 C  CG2 . THR A 1 225 ? 16.71690  9.77438   -42.33499 1.000 20.25577 ? 225 THR A CG2 1 
ATOM   1736 N  N   . THR A 1 226 ? 17.31321  11.51644  -45.65928 1.000 19.68325 ? 226 THR A N   1 
ATOM   1737 C  CA  . THR A 1 226 ? 16.30474  12.45555  -46.10235 1.000 23.01865 ? 226 THR A CA  1 
ATOM   1738 C  C   . THR A 1 226 ? 14.94549  11.99470  -45.58641 1.000 26.24059 ? 226 THR A C   1 
ATOM   1739 O  O   . THR A 1 226 ? 14.75169  10.82229  -45.24118 1.000 19.63810 ? 226 THR A O   1 
ATOM   1740 C  CB  . THR A 1 226 ? 16.29011  12.56404  -47.62930 1.000 22.04424 ? 226 THR A CB  1 
ATOM   1741 O  OG1 . THR A 1 226 ? 15.78854  11.34847  -48.19938 1.000 21.13018 ? 226 THR A OG1 1 
ATOM   1742 C  CG2 . THR A 1 226 ? 17.70064  12.79907  -48.15653 1.000 23.58741 ? 226 THR A CG2 1 
ATOM   1743 N  N   . LEU A 1 227 ? 14.00190  12.93665  -45.52350 1.000 22.17639 ? 227 LEU A N   1 
ATOM   1744 C  CA  . LEU A 1 227 ? 12.65161  12.57871  -45.10446 1.000 22.07049 ? 227 LEU A CA  1 
ATOM   1745 C  C   . LEU A 1 227 ? 12.04297  11.56274  -46.05782 1.000 21.98055 ? 227 LEU A C   1 
ATOM   1746 O  O   . LEU A 1 227 ? 11.41806  10.58665  -45.62305 1.000 22.96640 ? 227 LEU A O   1 
ATOM   1747 C  CB  . LEU A 1 227 ? 11.77132  13.82938  -45.01860 1.000 22.50742 ? 227 LEU A CB  1 
ATOM   1748 C  CG  . LEU A 1 227 ? 10.36524  13.62168  -44.44246 1.000 26.81523 ? 227 LEU A CG  1 
ATOM   1749 C  CD1 . LEU A 1 227 ? 10.42808  12.87983  -43.10784 1.000 22.97321 ? 227 LEU A CD1 1 
ATOM   1750 C  CD2 . LEU A 1 227 ? 9.65404   14.95831  -44.27101 1.000 23.22910 ? 227 LEU A CD2 1 
ATOM   1751 N  N   . ASN A 1 228 ? 12.23842  11.75622  -47.36502 1.000 19.39764 ? 228 ASN A N   1 
ATOM   1752 C  CA  . ASN A 1 228 ? 11.64559  10.83002  -48.32418 1.000 22.18796 ? 228 ASN A CA  1 
ATOM   1753 C  C   . ASN A 1 228 ? 12.27309  9.44204   -48.23497 1.000 20.57430 ? 228 ASN A C   1 
ATOM   1754 O  O   . ASN A 1 228 ? 11.56347  8.43183   -48.30167 1.000 21.02690 ? 228 ASN A O   1 
ATOM   1755 C  CB  . ASN A 1 228 ? 11.76583  11.37644  -49.74679 1.000 24.48773 ? 228 ASN A CB  1 
ATOM   1756 C  CG  . ASN A 1 228 ? 10.85183  10.64936  -50.71030 1.000 31.33460 ? 228 ASN A CG  1 
ATOM   1757 O  OD1 . ASN A 1 228 ? 9.62167   10.77967  -50.63975 1.000 38.89130 ? 228 ASN A OD1 1 
ATOM   1758 N  ND2 . ASN A 1 228 ? 11.43894  9.85996   -51.60187 1.000 31.98874 ? 228 ASN A ND2 1 
ATOM   1759 N  N   . ASP A 1 229 ? 13.60205  9.36404   -48.10629 1.000 23.31638 ? 229 ASP A N   1 
ATOM   1760 C  CA  . ASP A 1 229 ? 14.23860  8.05407   -47.99584 1.000 20.55540 ? 229 ASP A CA  1 
ATOM   1761 C  C   . ASP A 1 229 ? 13.80199  7.33604   -46.72110 1.000 19.05791 ? 229 ASP A C   1 
ATOM   1762 O  O   . ASP A 1 229 ? 13.60667  6.11484   -46.72704 1.000 18.07663 ? 229 ASP A O   1 
ATOM   1763 C  CB  . ASP A 1 229 ? 15.76322  8.19227   -48.04605 1.000 18.12434 ? 229 ASP A CB  1 
ATOM   1764 C  CG  . ASP A 1 229 ? 16.30125  8.32625   -49.47822 1.000 27.11503 ? 229 ASP A CG  1 
ATOM   1765 O  OD1 . ASP A 1 229 ? 15.50264  8.26327   -50.44941 1.000 24.10026 ? 229 ASP A OD1 1 
ATOM   1766 O  OD2 . ASP A 1 229 ? 17.53140  8.50034   -49.61993 1.000 25.26617 ? 229 ASP A OD2 1 
ATOM   1767 N  N   . PHE A 1 230 ? 13.65007  8.07374   -45.61524 1.000 18.82479 ? 230 PHE A N   1 
ATOM   1768 C  CA  . PHE A 1 230 ? 13.12609  7.46234   -44.39543 1.000 21.14225 ? 230 PHE A CA  1 
ATOM   1769 C  C   . PHE A 1 230 ? 11.74949  6.85200   -44.63240 1.000 21.81504 ? 230 PHE A C   1 
ATOM   1770 O  O   . PHE A 1 230 ? 11.48462  5.71141   -44.23406 1.000 19.97601 ? 230 PHE A O   1 
ATOM   1771 C  CB  . PHE A 1 230 ? 13.04643  8.47795   -43.25119 1.000 21.66880 ? 230 PHE A CB  1 
ATOM   1772 C  CG  . PHE A 1 230 ? 12.32355  7.93934   -42.05301 1.000 22.92163 ? 230 PHE A CG  1 
ATOM   1773 C  CD1 . PHE A 1 230 ? 12.98056  7.10367   -41.15253 1.000 20.29362 ? 230 PHE A CD1 1 
ATOM   1774 C  CD2 . PHE A 1 230 ? 10.97103  8.20063   -41.86219 1.000 21.72902 ? 230 PHE A CD2 1 
ATOM   1775 C  CE1 . PHE A 1 230 ? 12.31079  6.57641   -40.07490 1.000 20.17037 ? 230 PHE A CE1 1 
ATOM   1776 C  CE2 . PHE A 1 230 ? 10.29711  7.66599   -40.78790 1.000 19.73850 ? 230 PHE A CE2 1 
ATOM   1777 C  CZ  . PHE A 1 230 ? 10.96104  6.85806   -39.89221 1.000 22.29723 ? 230 PHE A CZ  1 
ATOM   1778 N  N   . ASN A 1 231 ? 10.85504  7.60345   -45.27781 1.000 21.61502 ? 231 ASN A N   1 
ATOM   1779 C  CA  . ASN A 1 231 ? 9.48738   7.12110   -45.46402 1.000 21.44578 ? 231 ASN A CA  1 
ATOM   1780 C  C   . ASN A 1 231 ? 9.43121   5.93052   -46.41195 1.000 21.07055 ? 231 ASN A C   1 
ATOM   1781 O  O   . ASN A 1 231 ? 8.62453   5.01736   -46.21440 1.000 22.38058 ? 231 ASN A O   1 
ATOM   1782 C  CB  . ASN A 1 231 ? 8.59459   8.25793   -45.96126 1.000 21.45340 ? 231 ASN A CB  1 
ATOM   1783 C  CG  . ASN A 1 231 ? 8.20682   9.20490   -44.84835 1.000 25.33423 ? 231 ASN A CG  1 
ATOM   1784 O  OD1 . ASN A 1 231 ? 8.08468   8.79447   -43.69736 1.000 23.89851 ? 231 ASN A OD1 1 
ATOM   1785 N  ND2 . ASN A 1 231 ? 8.01971   10.47738  -45.17883 1.000 27.28908 ? 231 ASN A ND2 1 
ATOM   1786 N  N   . LEU A 1 232 ? 10.27489  5.91174   -47.44844 1.000 20.40755 ? 232 LEU A N   1 
ATOM   1787 C  CA  . LEU A 1 232 ? 10.27684  4.76387   -48.34916 1.000 20.08012 ? 232 LEU A CA  1 
ATOM   1788 C  C   . LEU A 1 232 ? 10.67510  3.49142   -47.61355 1.000 21.90276 ? 232 LEU A C   1 
ATOM   1789 O  O   . LEU A 1 232 ? 10.16063  2.40708   -47.90916 1.000 24.38358 ? 232 LEU A O   1 
ATOM   1790 C  CB  . LEU A 1 232 ? 11.21414  5.01739   -49.53000 1.000 23.08901 ? 232 LEU A CB  1 
ATOM   1791 C  CG  . LEU A 1 232 ? 10.75693  6.05342   -50.55484 1.000 24.31482 ? 232 LEU A CG  1 
ATOM   1792 C  CD1 . LEU A 1 232 ? 11.88520  6.32958   -51.54760 1.000 22.62536 ? 232 LEU A CD1 1 
ATOM   1793 C  CD2 . LEU A 1 232 ? 9.49497   5.56354   -51.26717 1.000 19.64120 ? 232 LEU A CD2 1 
ATOM   1794 N  N   . VAL A 1 233 ? 11.58580  3.60395   -46.64659 1.000 21.05958 ? 233 VAL A N   1 
ATOM   1795 C  CA  . VAL A 1 233 ? 11.99600  2.44302   -45.85986 1.000 19.00052 ? 233 VAL A CA  1 
ATOM   1796 C  C   . VAL A 1 233 ? 10.95199  2.09984   -44.80523 1.000 19.37547 ? 233 VAL A C   1 
ATOM   1797 O  O   . VAL A 1 233 ? 10.50028  0.95170   -44.70797 1.000 18.38447 ? 233 VAL A O   1 
ATOM   1798 C  CB  . VAL A 1 233 ? 13.36202  2.69740   -45.20233 1.000 22.97489 ? 233 VAL A CB  1 
ATOM   1799 C  CG1 . VAL A 1 233 ? 13.69173  1.55340   -44.23602 1.000 16.86693 ? 233 VAL A CG1 1 
ATOM   1800 C  CG2 . VAL A 1 233 ? 14.42130  2.85888   -46.25843 1.000 18.42475 ? 233 VAL A CG2 1 
ATOM   1801 N  N   . ALA A 1 234 ? 10.56952  3.08592   -43.99072 1.000 18.01250 ? 234 ALA A N   1 
ATOM   1802 C  CA  . ALA A 1 234 ? 9.70692   2.80276   -42.84519 1.000 19.72012 ? 234 ALA A CA  1 
ATOM   1803 C  C   . ALA A 1 234 ? 8.36042   2.23932   -43.28334 1.000 18.27179 ? 234 ALA A C   1 
ATOM   1804 O  O   . ALA A 1 234 ? 7.81139   1.34791   -42.63153 1.000 20.47765 ? 234 ALA A O   1 
ATOM   1805 C  CB  . ALA A 1 234 ? 9.51242   4.06336   -42.00666 1.000 18.74702 ? 234 ALA A CB  1 
ATOM   1806 N  N   . MET A 1 235 ? 7.81861   2.72556   -44.39638 1.000 21.26652 ? 235 MET A N   1 
ATOM   1807 C  CA  . MET A 1 235 ? 6.52103   2.22086   -44.82564 1.000 21.46454 ? 235 MET A CA  1 
ATOM   1808 C  C   . MET A 1 235 ? 6.58361   0.75295   -45.23551 1.000 22.62276 ? 235 MET A C   1 
ATOM   1809 O  O   . MET A 1 235 ? 5.56261   0.06432   -45.19129 1.000 21.27010 ? 235 MET A O   1 
ATOM   1810 C  CB  . MET A 1 235 ? 5.97170   3.11606   -45.93737 1.000 26.57841 ? 235 MET A CB  1 
ATOM   1811 C  CG  . MET A 1 235 ? 5.71493   4.54219   -45.41260 1.000 29.86055 ? 235 MET A CG  1 
ATOM   1812 S  SD  . MET A 1 235 ? 5.08043   5.75940   -46.57741 1.000 45.40537 ? 235 MET A SD  1 
ATOM   1813 C  CE  . MET A 1 235 ? 3.60631   4.91414   -47.15965 1.000 41.75547 ? 235 MET A CE  1 
ATOM   1814 N  N   . LYS A 1 236 ? 7.76542   0.23274   -45.56287 1.000 20.20000 ? 236 LYS A N   1 
ATOM   1815 C  CA  . LYS A 1 236 ? 7.88654   -1.20108  -45.79492 1.000 21.60356 ? 236 LYS A CA  1 
ATOM   1816 C  C   . LYS A 1 236 ? 7.76149   -2.02653  -44.51869 1.000 23.34472 ? 236 LYS A C   1 
ATOM   1817 O  O   . LYS A 1 236 ? 7.60822   -3.24958  -44.61025 1.000 24.72794 ? 236 LYS A O   1 
ATOM   1818 C  CB  . LYS A 1 236 ? 9.21646   -1.51000  -46.48439 1.000 23.92321 ? 236 LYS A CB  1 
ATOM   1819 C  CG  . LYS A 1 236 ? 9.34252   -0.83007  -47.83778 1.000 21.86169 ? 236 LYS A CG  1 
ATOM   1820 C  CD  . LYS A 1 236 ? 10.77736  -0.80319  -48.33477 1.000 27.47133 ? 236 LYS A CD  1 
ATOM   1821 C  CE  . LYS A 1 236 ? 10.84841  -0.19514  -49.73047 1.000 27.19961 ? 236 LYS A CE  1 
ATOM   1822 N  NZ  . LYS A 1 236 ? 12.25933  -0.08816  -50.17899 1.000 31.89649 ? 236 LYS A NZ  1 
ATOM   1823 N  N   . TYR A 1 237 ? 7.84174   -1.40731  -43.33944 1.000 22.14501 ? 237 TYR A N   1 
ATOM   1824 C  CA  . TYR A 1 237 ? 7.57134   -2.10003  -42.08531 1.000 21.13407 ? 237 TYR A CA  1 
ATOM   1825 C  C   . TYR A 1 237 ? 6.18443   -1.77149  -41.53273 1.000 22.81271 ? 237 TYR A C   1 
ATOM   1826 O  O   . TYR A 1 237 ? 5.92857   -1.98534  -40.34362 1.000 20.32827 ? 237 TYR A O   1 
ATOM   1827 C  CB  . TYR A 1 237 ? 8.64102   -1.76280  -41.04902 1.000 22.02743 ? 237 TYR A CB  1 
ATOM   1828 C  CG  . TYR A 1 237 ? 10.06487  -2.09171  -41.46757 1.000 22.32850 ? 237 TYR A CG  1 
ATOM   1829 C  CD1 . TYR A 1 237 ? 10.83418  -1.17671  -42.19169 1.000 20.40615 ? 237 TYR A CD1 1 
ATOM   1830 C  CD2 . TYR A 1 237 ? 10.64627  -3.31103  -41.12463 1.000 19.76028 ? 237 TYR A CD2 1 
ATOM   1831 C  CE1 . TYR A 1 237 ? 12.15912  -1.47250  -42.55837 1.000 16.93163 ? 237 TYR A CE1 1 
ATOM   1832 C  CE2 . TYR A 1 237 ? 11.95358  -3.62009  -41.50070 1.000 17.44646 ? 237 TYR A CE2 1 
ATOM   1833 C  CZ  . TYR A 1 237 ? 12.70363  -2.69638  -42.21337 1.000 21.19178 ? 237 TYR A CZ  1 
ATOM   1834 O  OH  . TYR A 1 237 ? 14.00621  -3.00367  -42.56805 1.000 25.82516 ? 237 TYR A OH  1 
ATOM   1835 N  N   . ASN A 1 238 ? 5.29477   -1.24550  -42.37544 1.000 24.96468 ? 238 ASN A N   1 
ATOM   1836 C  CA  . ASN A 1 238 ? 3.95086   -0.82541  -41.96390 1.000 27.46871 ? 238 ASN A CA  1 
ATOM   1837 C  C   . ASN A 1 238 ? 4.00837   0.27416   -40.91036 1.000 24.84808 ? 238 ASN A C   1 
ATOM   1838 O  O   . ASN A 1 238 ? 3.25911   0.25989   -39.92974 1.000 24.00407 ? 238 ASN A O   1 
ATOM   1839 C  CB  . ASN A 1 238 ? 3.11142   -2.01005  -41.47699 1.000 26.74747 ? 238 ASN A CB  1 
ATOM   1840 C  CG  . ASN A 1 238 ? 2.38960   -2.70260  -42.61368 1.000 28.84167 ? 238 ASN A CG  1 
ATOM   1841 O  OD1 . ASN A 1 238 ? 2.36008   -2.19823  -43.73307 1.000 35.34858 ? 238 ASN A OD1 1 
ATOM   1842 N  ND2 . ASN A 1 238 ? 1.80486   -3.85421  -42.33535 1.000 34.30041 ? 238 ASN A ND2 1 
ATOM   1843 N  N   . TYR A 1 239 ? 4.91924   1.22435   -41.11124 1.000 20.42629 ? 239 TYR A N   1 
ATOM   1844 C  CA  . TYR A 1 239 ? 4.99166   2.43423   -40.30609 1.000 20.42008 ? 239 TYR A CA  1 
ATOM   1845 C  C   . TYR A 1 239 ? 4.24035   3.54444   -41.02741 1.000 22.79075 ? 239 TYR A C   1 
ATOM   1846 O  O   . TYR A 1 239 ? 4.23874   3.59685   -42.26092 1.000 24.66037 ? 239 TYR A O   1 
ATOM   1847 C  CB  . TYR A 1 239 ? 6.44995   2.84673   -40.06848 1.000 17.97030 ? 239 TYR A CB  1 
ATOM   1848 C  CG  . TYR A 1 239 ? 7.04613   2.26355   -38.81181 1.000 19.04845 ? 239 TYR A CG  1 
ATOM   1849 C  CD1 . TYR A 1 239 ? 7.07170   0.88700   -38.60100 1.000 19.41341 ? 239 TYR A CD1 1 
ATOM   1850 C  CD2 . TYR A 1 239 ? 7.57936   3.08843   -37.83088 1.000 19.53182 ? 239 TYR A CD2 1 
ATOM   1851 C  CE1 . TYR A 1 239 ? 7.60888   0.35246   -37.44365 1.000 16.65802 ? 239 TYR A CE1 1 
ATOM   1852 C  CE2 . TYR A 1 239 ? 8.11567   2.56476   -36.67153 1.000 16.66755 ? 239 TYR A CE2 1 
ATOM   1853 C  CZ  . TYR A 1 239 ? 8.12743   1.19778   -36.48504 1.000 19.31656 ? 239 TYR A CZ  1 
ATOM   1854 O  OH  . TYR A 1 239 ? 8.66211   0.68231   -35.32625 1.000 20.56209 ? 239 TYR A OH  1 
ATOM   1855 N  N   . GLU A 1 240 ? 3.59777   4.42029   -40.25731 1.000 20.89188 ? 240 GLU A N   1 
ATOM   1856 C  CA  . GLU A 1 240 ? 2.89294   5.55224   -40.83575 1.000 22.18995 ? 240 GLU A CA  1 
ATOM   1857 C  C   . GLU A 1 240 ? 3.89162   6.51449   -41.47097 1.000 21.75418 ? 240 GLU A C   1 
ATOM   1858 O  O   . GLU A 1 240 ? 5.02822   6.62509   -41.01155 1.000 22.87144 ? 240 GLU A O   1 
ATOM   1859 C  CB  . GLU A 1 240 ? 2.08347   6.29496   -39.76625 1.000 20.73415 ? 240 GLU A CB  1 
ATOM   1860 C  CG  . GLU A 1 240 ? 0.76626   5.64395   -39.40762 1.000 23.25195 ? 240 GLU A CG  1 
ATOM   1861 C  CD  . GLU A 1 240 ? -0.23127  5.72716   -40.54715 1.000 29.86704 ? 240 GLU A CD  1 
ATOM   1862 O  OE1 . GLU A 1 240 ? -0.56554  6.86029   -40.96048 1.000 33.39101 ? 240 GLU A OE1 1 
ATOM   1863 O  OE2 . GLU A 1 240 ? -0.65342  4.66461   -41.05120 1.000 26.28707 ? 240 GLU A OE2 1 
ATOM   1864 N  N   . PRO A 1 241 ? 3.49466   7.22327   -42.52880 1.000 25.27640 ? 241 PRO A N   1 
ATOM   1865 C  CA  . PRO A 1 241 ? 4.38927   8.24169   -43.08823 1.000 26.93256 ? 241 PRO A CA  1 
ATOM   1866 C  C   . PRO A 1 241 ? 4.68005   9.32035   -42.05537 1.000 26.54912 ? 241 PRO A C   1 
ATOM   1867 O  O   . PRO A 1 241 ? 3.80108   9.73445   -41.29549 1.000 29.32309 ? 241 PRO A O   1 
ATOM   1868 C  CB  . PRO A 1 241 ? 3.60349   8.79792   -44.28368 1.000 27.94783 ? 241 PRO A CB  1 
ATOM   1869 C  CG  . PRO A 1 241 ? 2.57430   7.75692   -44.59941 1.000 29.97973 ? 241 PRO A CG  1 
ATOM   1870 C  CD  . PRO A 1 241 ? 2.23030   7.12858   -43.27832 1.000 25.99234 ? 241 PRO A CD  1 
ATOM   1871 N  N   . LEU A 1 242 ? 5.93244   9.75814   -42.01898 1.000 23.93123 ? 242 LEU A N   1 
ATOM   1872 C  CA  . LEU A 1 242 ? 6.33217   10.89446  -41.20359 1.000 22.00394 ? 242 LEU A CA  1 
ATOM   1873 C  C   . LEU A 1 242 ? 6.29152   12.15270  -42.06670 1.000 25.30945 ? 242 LEU A C   1 
ATOM   1874 O  O   . LEU A 1 242 ? 6.92754   12.20718  -43.12396 1.000 28.96176 ? 242 LEU A O   1 
ATOM   1875 C  CB  . LEU A 1 242 ? 7.73719   10.67553  -40.62878 1.000 23.60550 ? 242 LEU A CB  1 
ATOM   1876 C  CG  . LEU A 1 242 ? 8.21245   11.62648  -39.53353 1.000 20.77719 ? 242 LEU A CG  1 
ATOM   1877 C  CD1 . LEU A 1 242 ? 7.58210   11.26943  -38.17982 1.000 14.76386 ? 242 LEU A CD1 1 
ATOM   1878 C  CD2 . LEU A 1 242 ? 9.73792   11.63138  -39.44179 1.000 22.45774 ? 242 LEU A CD2 1 
ATOM   1879 N  N   . THR A 1 243 ? 5.54651   13.15362  -41.61252 1.000 24.46485 ? 243 THR A N   1 
ATOM   1880 C  CA  . THR A 1 243 ? 5.33609   14.40780  -42.31830 1.000 26.32305 ? 243 THR A CA  1 
ATOM   1881 C  C   . THR A 1 243 ? 6.23746   15.49427  -41.74430 1.000 26.56630 ? 243 THR A C   1 
ATOM   1882 O  O   . THR A 1 243 ? 6.78881   15.36331  -40.64710 1.000 26.35930 ? 243 THR A O   1 
ATOM   1883 C  CB  . THR A 1 243 ? 3.87545   14.85499  -42.19845 1.000 28.81300 ? 243 THR A CB  1 
ATOM   1884 O  OG1 . THR A 1 243 ? 3.60011   15.18038  -40.82585 1.000 24.96606 ? 243 THR A OG1 1 
ATOM   1885 C  CG2 . THR A 1 243 ? 2.94172   13.75281  -42.63953 1.000 26.13392 ? 243 THR A CG2 1 
ATOM   1886 N  N   . GLN A 1 244 ? 6.37334   16.58756  -42.49928 1.000 27.53058 ? 244 GLN A N   1 
ATOM   1887 C  CA  . GLN A 1 244 ? 7.14220   17.71990  -41.98903 1.000 28.67628 ? 244 GLN A CA  1 
ATOM   1888 C  C   . GLN A 1 244 ? 6.52646   18.27512  -40.71142 1.000 26.04747 ? 244 GLN A C   1 
ATOM   1889 O  O   . GLN A 1 244 ? 7.25389   18.73249  -39.82150 1.000 28.08300 ? 244 GLN A O   1 
ATOM   1890 C  CB  . GLN A 1 244 ? 7.25140   18.81225  -43.05484 1.000 29.86979 ? 244 GLN A CB  1 
ATOM   1891 C  CG  . GLN A 1 244 ? 8.13277   19.98803  -42.64060 1.000 30.68267 ? 244 GLN A CG  1 
ATOM   1892 C  CD  . GLN A 1 244 ? 9.54160   19.55414  -42.27326 1.000 33.97952 ? 244 GLN A CD  1 
ATOM   1893 O  OE1 . GLN A 1 244 ? 10.18425  18.80177  -43.00798 1.000 35.08658 ? 244 GLN A OE1 1 
ATOM   1894 N  NE2 . GLN A 1 244 ? 10.02242  20.01354  -41.12126 1.000 35.62895 ? 244 GLN A NE2 1 
ATOM   1895 N  N   . ASP A 1 245 ? 5.19322   18.24253  -40.60326 1.000 26.63066 ? 245 ASP A N   1 
ATOM   1896 C  CA  . ASP A 1 245 ? 4.52840   18.60115  -39.35163 1.000 24.36780 ? 245 ASP A CA  1 
ATOM   1897 C  C   . ASP A 1 245 ? 5.10621   17.80908  -38.19050 1.000 26.89930 ? 245 ASP A C   1 
ATOM   1898 O  O   . ASP A 1 245 ? 5.45574   18.37030  -37.14336 1.000 25.89157 ? 245 ASP A O   1 
ATOM   1899 C  CB  . ASP A 1 245 ? 3.02048   18.34400  -39.45055 1.000 30.95465 ? 245 ASP A CB  1 
ATOM   1900 C  CG  . ASP A 1 245 ? 2.26415   19.48190  -40.11101 1.000 35.31992 ? 245 ASP A CG  1 
ATOM   1901 O  OD1 . ASP A 1 245 ? 2.89109   20.30954  -40.79746 1.000 37.15581 ? 245 ASP A OD1 1 
ATOM   1902 O  OD2 . ASP A 1 245 ? 1.02997   19.54752  -39.93356 1.000 42.60761 ? 245 ASP A OD2 1 
ATOM   1903 N  N   . HIS A 1 246 ? 5.20037   16.49002  -38.36242 1.000 23.59796 ? 246 HIS A N   1 
ATOM   1904 C  CA  . HIS A 1 246 ? 5.78440   15.64325  -37.33223 1.000 26.02479 ? 246 HIS A CA  1 
ATOM   1905 C  C   . HIS A 1 246 ? 7.20999   16.07774  -37.01244 1.000 26.21303 ? 246 HIS A C   1 
ATOM   1906 O  O   . HIS A 1 246 ? 7.59817   16.14058  -35.84101 1.000 26.70126 ? 246 HIS A O   1 
ATOM   1907 C  CB  . HIS A 1 246 ? 5.75660   14.18406  -37.78664 1.000 21.42631 ? 246 HIS A CB  1 
ATOM   1908 C  CG  . HIS A 1 246 ? 4.37948   13.60768  -37.91954 1.000 24.30157 ? 246 HIS A CG  1 
ATOM   1909 N  ND1 . HIS A 1 246 ? 4.04311   12.71320  -38.91299 1.000 24.60554 ? 246 HIS A ND1 1 
ATOM   1910 C  CD2 . HIS A 1 246 ? 3.25981   13.78154  -37.17589 1.000 23.63960 ? 246 HIS A CD2 1 
ATOM   1911 C  CE1 . HIS A 1 246 ? 2.77318   12.37136  -38.78334 1.000 26.93917 ? 246 HIS A CE1 1 
ATOM   1912 N  NE2 . HIS A 1 246 ? 2.27608   13.00155  -37.73445 1.000 21.01504 ? 246 HIS A NE2 1 
ATOM   1913 N  N   . VAL A 1 247 ? 7.99785   16.38765  -38.04635 1.000 27.26523 ? 247 VAL A N   1 
ATOM   1914 C  CA  . VAL A 1 247 ? 9.37455   16.83326  -37.84268 1.000 27.76286 ? 247 VAL A CA  1 
ATOM   1915 C  C   . VAL A 1 247 ? 9.40371   18.08738  -36.97884 1.000 31.14490 ? 247 VAL A C   1 
ATOM   1916 O  O   . VAL A 1 247 ? 10.17305  18.17997  -36.01494 1.000 26.65292 ? 247 VAL A O   1 
ATOM   1917 C  CB  . VAL A 1 247 ? 10.07131  17.06467  -39.19695 1.000 29.57339 ? 247 VAL A CB  1 
ATOM   1918 C  CG1 . VAL A 1 247 ? 11.45067  17.68920  -38.98793 1.000 28.34180 ? 247 VAL A CG1 1 
ATOM   1919 C  CG2 . VAL A 1 247 ? 10.19876  15.75517  -39.96300 1.000 27.75900 ? 247 VAL A CG2 1 
ATOM   1920 N  N   . ASP A 1 248 ? 8.56391   19.07347  -37.31253 1.000 30.58431 ? 248 ASP A N   1 
ATOM   1921 C  CA  . ASP A 1 248 ? 8.48887   20.28386  -36.49851 1.000 28.53998 ? 248 ASP A CA  1 
ATOM   1922 C  C   . ASP A 1 248 ? 8.10270   19.95585  -35.06341 1.000 29.63319 ? 248 ASP A C   1 
ATOM   1923 O  O   . ASP A 1 248 ? 8.66513   20.51357  -34.11390 1.000 29.36841 ? 248 ASP A O   1 
ATOM   1924 C  CB  . ASP A 1 248 ? 7.48506   21.26696  -37.10603 1.000 32.26843 ? 248 ASP A CB  1 
ATOM   1925 C  CG  . ASP A 1 248 ? 7.88540   21.73504  -38.49361 1.000 33.12880 ? 248 ASP A CG  1 
ATOM   1926 O  OD1 . ASP A 1 248 ? 9.07634   21.61808  -38.85642 1.000 38.42241 ? 248 ASP A OD1 1 
ATOM   1927 O  OD2 . ASP A 1 248 ? 7.00516   22.22947  -39.22498 1.000 35.90448 ? 248 ASP A OD2 1 
ATOM   1928 N  N   . ILE A 1 249 ? 7.15078   19.03713  -34.88847 1.000 30.45485 ? 249 ILE A N   1 
ATOM   1929 C  CA  . ILE A 1 249 ? 6.67487   18.67610  -33.55887 1.000 31.95157 ? 249 ILE A CA  1 
ATOM   1930 C  C   . ILE A 1 249 ? 7.80532   18.09825  -32.72033 1.000 28.08516 ? 249 ILE A C   1 
ATOM   1931 O  O   . ILE A 1 249 ? 7.85092   18.29637  -31.49779 1.000 24.33471 ? 249 ILE A O   1 
ATOM   1932 C  CB  . ILE A 1 249 ? 5.48627   17.69709  -33.68642 1.000 28.96202 ? 249 ILE A CB  1 
ATOM   1933 C  CG1 . ILE A 1 249 ? 4.24447   18.43738  -34.18342 1.000 35.89447 ? 249 ILE A CG1 1 
ATOM   1934 C  CG2 . ILE A 1 249 ? 5.19171   17.01755  -32.37315 1.000 29.08709 ? 249 ILE A CG2 1 
ATOM   1935 C  CD1 . ILE A 1 249 ? 3.05719   17.52117  -34.47851 1.000 38.88765 ? 249 ILE A CD1 1 
ATOM   1936 N  N   . LEU A 1 250 ? 8.74566   17.39993  -33.35688 1.000 27.59604 ? 250 LEU A N   1 
ATOM   1937 C  CA  . LEU A 1 250 ? 9.85486   16.79041  -32.63518 1.000 25.09512 ? 250 LEU A CA  1 
ATOM   1938 C  C   . LEU A 1 250 ? 10.99295  17.76593  -32.36028 1.000 28.21182 ? 250 LEU A C   1 
ATOM   1939 O  O   . LEU A 1 250 ? 11.94057  17.39808  -31.65941 1.000 26.29801 ? 250 LEU A O   1 
ATOM   1940 C  CB  . LEU A 1 250 ? 10.38052  15.58035  -33.41105 1.000 24.75171 ? 250 LEU A CB  1 
ATOM   1941 C  CG  . LEU A 1 250 ? 9.46583   14.35085  -33.42913 1.000 26.17038 ? 250 LEU A CG  1 
ATOM   1942 C  CD1 . LEU A 1 250 ? 9.88797   13.33427  -34.49298 1.000 18.63595 ? 250 LEU A CD1 1 
ATOM   1943 C  CD2 . LEU A 1 250 ? 9.39508   13.69955  -32.05052 1.000 22.41500 ? 250 LEU A CD2 1 
ATOM   1944 N  N   . GLY A 1 251 ? 10.90583  18.98988  -32.87221 1.000 28.70747 ? 251 GLY A N   1 
ATOM   1945 C  CA  . GLY A 1 251 ? 11.94051  19.99083  -32.73644 1.000 28.15458 ? 251 GLY A CA  1 
ATOM   1946 C  C   . GLY A 1 251 ? 12.42546  20.23254  -31.31975 1.000 31.82410 ? 251 GLY A C   1 
ATOM   1947 O  O   . GLY A 1 251 ? 13.63184  20.24570  -31.05410 1.000 36.16871 ? 251 GLY A O   1 
ATOM   1948 N  N   . PRO A 1 252 ? 11.49825  20.46154  -30.38455 1.000 31.73508 ? 252 PRO A N   1 
ATOM   1949 C  CA  . PRO A 1 252 ? 11.91364  20.63576  -28.97936 1.000 32.14721 ? 252 PRO A CA  1 
ATOM   1950 C  C   . PRO A 1 252 ? 12.70236  19.46606  -28.40936 1.000 32.57676 ? 252 PRO A C   1 
ATOM   1951 O  O   . PRO A 1 252 ? 13.68145  19.68402  -27.68342 1.000 35.41857 ? 252 PRO A O   1 
ATOM   1952 C  CB  . PRO A 1 252 ? 10.57538  20.82889  -28.25466 1.000 30.57112 ? 252 PRO A CB  1 
ATOM   1953 C  CG  . PRO A 1 252 ? 9.71952   21.49571  -29.26692 1.000 29.35921 ? 252 PRO A CG  1 
ATOM   1954 C  CD  . PRO A 1 252 ? 10.10723  20.90385  -30.59842 1.000 32.62997 ? 252 PRO A CD  1 
ATOM   1955 N  N   . LEU A 1 253 ? 12.30228  18.22772  -28.70078 1.000 29.21492 ? 253 LEU A N   1 
ATOM   1956 C  CA  . LEU A 1 253 ? 13.06402  17.08110  -28.21185 1.000 28.76936 ? 253 LEU A CA  1 
ATOM   1957 C  C   . LEU A 1 253 ? 14.41876  16.98364  -28.90773 1.000 30.22555 ? 253 LEU A C   1 
ATOM   1958 O  O   . LEU A 1 253 ? 15.41393  16.57140  -28.29608 1.000 29.50919 ? 253 LEU A O   1 
ATOM   1959 C  CB  . LEU A 1 253 ? 12.25699  15.79650  -28.40590 1.000 23.90277 ? 253 LEU A CB  1 
ATOM   1960 C  CG  . LEU A 1 253 ? 11.08902  15.55934  -27.44305 1.000 27.88624 ? 253 LEU A CG  1 
ATOM   1961 C  CD1 . LEU A 1 253 ? 10.24165  14.37254  -27.88305 1.000 19.27352 ? 253 LEU A CD1 1 
ATOM   1962 C  CD2 . LEU A 1 253 ? 11.58177  15.34399  -26.00695 1.000 29.10565 ? 253 LEU A CD2 1 
ATOM   1963 N  N   . SER A 1 254 ? 14.47252  17.34810  -30.19065 1.000 28.82913 ? 254 SER A N   1 
ATOM   1964 C  CA  . SER A 1 254 ? 15.74905  17.40865  -30.89438 1.000 33.60743 ? 254 SER A CA  1 
ATOM   1965 C  C   . SER A 1 254 ? 16.69702  18.38917  -30.21359 1.000 36.19363 ? 254 SER A C   1 
ATOM   1966 O  O   . SER A 1 254 ? 17.85345  18.05851  -29.91978 1.000 32.52193 ? 254 SER A O   1 
ATOM   1967 C  CB  . SER A 1 254 ? 15.51430  17.80157  -32.35361 1.000 30.19151 ? 254 SER A CB  1 
ATOM   1968 O  OG  . SER A 1 254 ? 16.72815  17.92948  -33.06037 1.000 33.95187 ? 254 SER A OG  1 
ATOM   1969 N  N   . ALA A 1 255 ? 16.20918  19.60098  -29.93699 1.000 38.67238 ? 255 ALA A N   1 
ATOM   1970 C  CA  . ALA A 1 255 ? 17.04456  20.62525  -29.31643 1.000 38.87301 ? 255 ALA A CA  1 
ATOM   1971 C  C   . ALA A 1 255 ? 17.51309  20.20300  -27.92889 1.000 35.20171 ? 255 ALA A C   1 
ATOM   1972 O  O   . ALA A 1 255 ? 18.65725  20.46953  -27.54519 1.000 37.45885 ? 255 ALA A O   1 
ATOM   1973 C  CB  . ALA A 1 255 ? 16.27774  21.94700  -29.24644 1.000 38.76557 ? 255 ALA A CB  1 
ATOM   1974 N  N   . GLN A 1 256 ? 16.64904  19.53569  -27.16463 1.000 33.94446 ? 256 GLN A N   1 
ATOM   1975 C  CA  . GLN A 1 256 ? 17.02588  19.13379  -25.81559 1.000 33.43264 ? 256 GLN A CA  1 
ATOM   1976 C  C   . GLN A 1 256 ? 18.15200  18.10702  -25.82925 1.000 37.10839 ? 256 GLN A C   1 
ATOM   1977 O  O   . GLN A 1 256 ? 19.04830  18.15045  -24.97679 1.000 38.50873 ? 256 GLN A O   1 
ATOM   1978 C  CB  . GLN A 1 256 ? 15.81520  18.57671  -25.07030 1.000 39.72056 ? 256 GLN A CB  1 
ATOM   1979 C  CG  . GLN A 1 256 ? 16.16144  18.07751  -23.67579 1.000 39.18651 ? 256 GLN A CG  1 
ATOM   1980 C  CD  . GLN A 1 256 ? 14.96169  17.58734  -22.90756 1.000 42.59062 ? 256 GLN A CD  1 
ATOM   1981 O  OE1 . GLN A 1 256 ? 13.81805  17.86841  -23.26928 1.000 46.44905 ? 256 GLN A OE1 1 
ATOM   1982 N  NE2 . GLN A 1 256 ? 15.21350  16.84266  -21.83809 1.000 36.91672 ? 256 GLN A NE2 1 
ATOM   1983 N  N   . THR A 1 257 ? 18.12319  17.17407  -26.78011 1.000 30.90441 ? 257 THR A N   1 
ATOM   1984 C  CA  . THR A 1 257 ? 19.08405  16.08017  -26.81559 1.000 33.97781 ? 257 THR A CA  1 
ATOM   1985 C  C   . THR A 1 257 ? 20.27668  16.35909  -27.71399 1.000 34.45884 ? 257 THR A C   1 
ATOM   1986 O  O   . THR A 1 257 ? 21.26052  15.61470  -27.65395 1.000 35.93488 ? 257 THR A O   1 
ATOM   1987 C  CB  . THR A 1 257 ? 18.41055  14.78767  -27.28843 1.000 30.57787 ? 257 THR A CB  1 
ATOM   1988 O  OG1 . THR A 1 257 ? 17.87301  14.99211  -28.60047 1.000 29.84186 ? 257 THR A OG1 1 
ATOM   1989 C  CG2 . THR A 1 257 ? 17.30058  14.38358  -26.33971 1.000 28.47389 ? 257 THR A CG2 1 
ATOM   1990 N  N   . GLY A 1 258 ? 20.21168  17.40011  -28.54023 1.000 33.45548 ? 258 GLY A N   1 
ATOM   1991 C  CA  . GLY A 1 258 ? 21.23804  17.64754  -29.52580 1.000 33.00202 ? 258 GLY A CA  1 
ATOM   1992 C  C   . GLY A 1 258 ? 21.26190  16.68714  -30.69284 1.000 35.32677 ? 258 GLY A C   1 
ATOM   1993 O  O   . GLY A 1 258 ? 22.24880  16.67197  -31.43264 1.000 35.17555 ? 258 GLY A O   1 
ATOM   1994 N  N   . ILE A 1 259 ? 20.21278  15.89011  -30.89259 1.000 28.45844 ? 259 ILE A N   1 
ATOM   1995 C  CA  . ILE A 1 259 ? 20.14834  14.92484  -31.98843 1.000 29.47124 ? 259 ILE A CA  1 
ATOM   1996 C  C   . ILE A 1 259 ? 19.10072  15.39509  -32.98844 1.000 28.44801 ? 259 ILE A C   1 
ATOM   1997 O  O   . ILE A 1 259 ? 17.91837  15.52849  -32.64398 1.000 28.55143 ? 259 ILE A O   1 
ATOM   1998 C  CB  . ILE A 1 259 ? 19.82103  13.51367  -31.48266 1.000 26.37331 ? 259 ILE A CB  1 
ATOM   1999 C  CG1 . ILE A 1 259 ? 20.86793  13.05892  -30.46429 1.000 33.29021 ? 259 ILE A CG1 1 
ATOM   2000 C  CG2 . ILE A 1 259 ? 19.73412  12.54673  -32.64730 1.000 22.87658 ? 259 ILE A CG2 1 
ATOM   2001 C  CD1 . ILE A 1 259 ? 20.52726  11.74846  -29.77932 1.000 24.90819 ? 259 ILE A CD1 1 
ATOM   2002 N  N   . ALA A 1 260 ? 19.53650  15.64254  -34.22171 1.000 27.71445 ? 260 ALA A N   1 
ATOM   2003 C  CA  . ALA A 1 260 ? 18.63747  16.09823  -35.27435 1.000 31.00497 ? 260 ALA A CA  1 
ATOM   2004 C  C   . ALA A 1 260 ? 17.55519  15.05884  -35.54822 1.000 26.55256 ? 260 ALA A C   1 
ATOM   2005 O  O   . ALA A 1 260 ? 17.79767  13.85159  -35.46798 1.000 24.95032 ? 260 ALA A O   1 
ATOM   2006 C  CB  . ALA A 1 260 ? 19.42636  16.38191  -36.55623 1.000 26.11766 ? 260 ALA A CB  1 
ATOM   2007 N  N   . VAL A 1 261 ? 16.35247  15.54011  -35.87513 1.000 24.88443 ? 261 VAL A N   1 
ATOM   2008 C  CA  . VAL A 1 261 ? 15.22283  14.64159  -36.10568 1.000 23.32870 ? 261 VAL A CA  1 
ATOM   2009 C  C   . VAL A 1 261 ? 15.55862  13.62291  -37.18997 1.000 19.70084 ? 261 VAL A C   1 
ATOM   2010 O  O   . VAL A 1 261 ? 15.30993  12.42246  -37.03504 1.000 22.25440 ? 261 VAL A O   1 
ATOM   2011 C  CB  . VAL A 1 261 ? 13.95651  15.44355  -36.45622 1.000 25.63089 ? 261 VAL A CB  1 
ATOM   2012 C  CG1 . VAL A 1 261 ? 12.83296  14.49398  -36.84126 1.000 23.39430 ? 261 VAL A CG1 1 
ATOM   2013 C  CG2 . VAL A 1 261 ? 13.53155  16.32867  -35.27713 1.000 24.32024 ? 261 VAL A CG2 1 
ATOM   2014 N  N   . LEU A 1 262 ? 16.14251  14.08359  -38.29850 1.000 22.36980 ? 262 LEU A N   1 
ATOM   2015 C  CA  . LEU A 1 262 ? 16.51479  13.16720  -39.37371 1.000 24.25724 ? 262 LEU A CA  1 
ATOM   2016 C  C   . LEU A 1 262 ? 17.64625  12.23229  -38.96736 1.000 22.23457 ? 262 LEU A C   1 
ATOM   2017 O  O   . LEU A 1 262 ? 17.76298  11.14491  -39.53758 1.000 21.71802 ? 262 LEU A O   1 
ATOM   2018 C  CB  . LEU A 1 262 ? 16.88853  13.95339  -40.62859 1.000 23.05681 ? 262 LEU A CB  1 
ATOM   2019 C  CG  . LEU A 1 262 ? 15.67357  14.63236  -41.27956 1.000 30.73114 ? 262 LEU A CG  1 
ATOM   2020 C  CD1 . LEU A 1 262 ? 16.05227  15.40976  -42.54410 1.000 25.33681 ? 262 LEU A CD1 1 
ATOM   2021 C  CD2 . LEU A 1 262 ? 14.61707  13.59580  -41.59706 1.000 23.99926 ? 262 LEU A CD2 1 
ATOM   2022 N  N   . ASP A 1 263 ? 18.46653  12.61691  -37.98434 1.000 22.60340 ? 263 ASP A N   1 
ATOM   2023 C  CA  . ASP A 1 263 ? 19.45991  11.68283  -37.45824 1.000 24.32472 ? 263 ASP A CA  1 
ATOM   2024 C  C   . ASP A 1 263 ? 18.79695  10.59258  -36.62090 1.000 24.37064 ? 263 ASP A C   1 
ATOM   2025 O  O   . ASP A 1 263 ? 19.19107  9.42268   -36.68806 1.000 22.85851 ? 263 ASP A O   1 
ATOM   2026 C  CB  . ASP A 1 263 ? 20.51485  12.42845  -36.63267 1.000 27.02498 ? 263 ASP A CB  1 
ATOM   2027 C  CG  . ASP A 1 263 ? 21.48248  13.24964  -37.49917 1.000 28.80342 ? 263 ASP A CG  1 
ATOM   2028 O  OD1 . ASP A 1 263 ? 21.30480  13.29915  -38.73008 1.000 26.53358 ? 263 ASP A OD1 1 
ATOM   2029 O  OD2 . ASP A 1 263 ? 22.42322  13.84447  -36.93452 1.000 29.67059 ? 263 ASP A OD2 1 
ATOM   2030 N  N   . MET A 1 264 ? 17.79231  10.95353  -35.81687 1.000 21.70078 ? 264 MET A N   1 
ATOM   2031 C  CA  . MET A 1 264 ? 17.04792  9.92526   -35.09637 1.000 22.43855 ? 264 MET A CA  1 
ATOM   2032 C  C   . MET A 1 264 ? 16.27884  9.02710   -36.05787 1.000 22.53447 ? 264 MET A C   1 
ATOM   2033 O  O   . MET A 1 264 ? 16.13869  7.82485   -35.79853 1.000 21.02932 ? 264 MET A O   1 
ATOM   2034 C  CB  . MET A 1 264 ? 16.09454  10.55723  -34.07919 1.000 20.34523 ? 264 MET A CB  1 
ATOM   2035 C  CG  . MET A 1 264 ? 15.46451  9.55105   -33.11218 1.000 24.73194 ? 264 MET A CG  1 
ATOM   2036 S  SD  . MET A 1 264 ? 16.67686  8.83950   -31.96202 1.000 22.36992 ? 264 MET A SD  1 
ATOM   2037 C  CE  . MET A 1 264 ? 16.85536  10.16414  -30.77059 1.000 21.31462 ? 264 MET A CE  1 
ATOM   2038 N  N   . CYS A 1 265 ? 15.77765  9.58942   -37.16781 1.000 20.87890 ? 265 CYS A N   1 
ATOM   2039 C  CA  . CYS A 1 265 ? 15.15560  8.76609   -38.19886 1.000 19.35769 ? 265 CYS A CA  1 
ATOM   2040 C  C   . CYS A 1 265 ? 16.13173  7.71900   -38.72378 1.000 20.67271 ? 265 CYS A C   1 
ATOM   2041 O  O   . CYS A 1 265 ? 15.74627  6.57118   -38.97249 1.000 17.86985 ? 265 CYS A O   1 
ATOM   2042 C  CB  . CYS A 1 265 ? 14.63787  9.64569   -39.33861 1.000 20.96526 ? 265 CYS A CB  1 
ATOM   2043 S  SG  . CYS A 1 265 ? 13.14614  10.59476  -38.90184 1.000 22.25465 ? 265 CYS A SG  1 
ATOM   2044 N  N   . ALA A 1 266 ? 17.40477  8.09438   -38.88256 1.000 17.37101 ? 266 ALA A N   1 
ATOM   2045 C  CA  . ALA A 1 266 ? 18.41249  7.13011   -39.31063 1.000 19.28953 ? 266 ALA A CA  1 
ATOM   2046 C  C   . ALA A 1 266 ? 18.55417  5.99737   -38.30401 1.000 18.47812 ? 266 ALA A C   1 
ATOM   2047 O  O   . ALA A 1 266 ? 18.67887  4.82986   -38.68792 1.000 21.04488 ? 266 ALA A O   1 
ATOM   2048 C  CB  . ALA A 1 266 ? 19.75819  7.83364   -39.52253 1.000 16.26308 ? 266 ALA A CB  1 
ATOM   2049 N  N   . SER A 1 267 ? 18.54728  6.32550   -37.00751 1.000 19.26502 ? 267 SER A N   1 
ATOM   2050 C  CA  . SER A 1 267 ? 18.62027  5.29659   -35.96947 1.000 18.39453 ? 267 SER A CA  1 
ATOM   2051 C  C   . SER A 1 267 ? 17.42052  4.35616   -36.03480 1.000 18.47001 ? 267 SER A C   1 
ATOM   2052 O  O   . SER A 1 267 ? 17.56732  3.13406   -35.91785 1.000 16.09699 ? 267 SER A O   1 
ATOM   2053 C  CB  . SER A 1 267 ? 18.72121  5.96566   -34.59442 1.000 24.05698 ? 267 SER A CB  1 
ATOM   2054 O  OG  . SER A 1 267 ? 18.54423  5.03088   -33.54520 1.000 25.72343 ? 267 SER A OG  1 
ATOM   2055 N  N   . LEU A 1 268 ? 16.22314  4.90662   -36.23795 1.000 18.95380 ? 268 LEU A N   1 
ATOM   2056 C  CA  . LEU A 1 268 ? 15.03763  4.06047   -36.35466 1.000 16.18547 ? 268 LEU A CA  1 
ATOM   2057 C  C   . LEU A 1 268 ? 15.12614  3.13866   -37.57122 1.000 16.79921 ? 268 LEU A C   1 
ATOM   2058 O  O   . LEU A 1 268 ? 14.82307  1.94610   -37.46936 1.000 20.44635 ? 268 LEU A O   1 
ATOM   2059 C  CB  . LEU A 1 268 ? 13.77838  4.92814   -36.40785 1.000 15.71885 ? 268 LEU A CB  1 
ATOM   2060 C  CG  . LEU A 1 268 ? 12.45394  4.17467   -36.63874 1.000 18.14667 ? 268 LEU A CG  1 
ATOM   2061 C  CD1 . LEU A 1 268 ? 12.28794  3.04669   -35.63024 1.000 16.68675 ? 268 LEU A CD1 1 
ATOM   2062 C  CD2 . LEU A 1 268 ? 11.27710  5.13366   -36.57834 1.000 18.85530 ? 268 LEU A CD2 1 
ATOM   2063 N  N   . LYS A 1 269 ? 15.57569  3.65739   -38.72063 1.000 16.52981 ? 269 LYS A N   1 
ATOM   2064 C  CA  . LYS A 1 269 ? 15.76073  2.80019   -39.89102 1.000 17.49586 ? 269 LYS A CA  1 
ATOM   2065 C  C   . LYS A 1 269 ? 16.65839  1.60900   -39.57538 1.000 20.26578 ? 269 LYS A C   1 
ATOM   2066 O  O   . LYS A 1 269 ? 16.36422  0.47724   -39.98046 1.000 18.44767 ? 269 LYS A O   1 
ATOM   2067 C  CB  . LYS A 1 269 ? 16.34807  3.60334   -41.05566 1.000 22.20395 ? 269 LYS A CB  1 
ATOM   2068 C  CG  . LYS A 1 269 ? 15.37754  4.55103   -41.73363 1.000 25.20535 ? 269 LYS A CG  1 
ATOM   2069 C  CD  . LYS A 1 269 ? 16.10265  5.60251   -42.56204 1.000 23.99117 ? 269 LYS A CD  1 
ATOM   2070 C  CE  . LYS A 1 269 ? 16.59414  5.05732   -43.89903 1.000 20.54919 ? 269 LYS A CE  1 
ATOM   2071 N  NZ  . LYS A 1 269 ? 17.43398  6.09892   -44.56145 1.000 19.95530 ? 269 LYS A NZ  1 
ATOM   2072 N  N   . GLU A 1 270 ? 17.76624  1.84796   -38.86324 1.000 20.01155 ? 270 GLU A N   1 
ATOM   2073 C  CA  . GLU A 1 270 ? 18.67563  0.75979   -38.50716 1.000 20.74405 ? 270 GLU A CA  1 
ATOM   2074 C  C   . GLU A 1 270 ? 18.04371  -0.19802  -37.50026 1.000 16.28995 ? 270 GLU A C   1 
ATOM   2075 O  O   . GLU A 1 270 ? 18.27670  -1.41057  -37.56738 1.000 19.19800 ? 270 GLU A O   1 
ATOM   2076 C  CB  . GLU A 1 270 ? 19.98281  1.33814   -37.96011 1.000 21.05495 ? 270 GLU A CB  1 
ATOM   2077 C  CG  . GLU A 1 270 ? 21.02145  0.30614   -37.54381 1.000 22.42881 ? 270 GLU A CG  1 
ATOM   2078 C  CD  . GLU A 1 270 ? 22.39551  0.92687   -37.31665 1.000 22.77345 ? 270 GLU A CD  1 
ATOM   2079 O  OE1 . GLU A 1 270 ? 23.13443  1.13158   -38.30308 1.000 26.24625 ? 270 GLU A OE1 1 
ATOM   2080 O  OE2 . GLU A 1 270 ? 22.73021  1.23085   -36.15459 1.000 26.80524 ? 270 GLU A OE2 1 
ATOM   2081 N  N   . LEU A 1 271 ? 17.22766  0.31662   -36.57982 1.000 18.70422 ? 271 LEU A N   1 
ATOM   2082 C  CA  . LEU A 1 271 ? 16.56550  -0.55018  -35.60204 1.000 20.90654 ? 271 LEU A CA  1 
ATOM   2083 C  C   . LEU A 1 271 ? 15.55274  -1.47284  -36.27042 1.000 20.83985 ? 271 LEU A C   1 
ATOM   2084 O  O   . LEU A 1 271 ? 15.43948  -2.64825  -35.89906 1.000 19.01282 ? 271 LEU A O   1 
ATOM   2085 C  CB  . LEU A 1 271 ? 15.89452  0.29429   -34.51423 1.000 19.25417 ? 271 LEU A CB  1 
ATOM   2086 C  CG  . LEU A 1 271 ? 16.75232  0.79355   -33.34281 1.000 19.55568 ? 271 LEU A CG  1 
ATOM   2087 C  CD1 . LEU A 1 271 ? 16.04632  1.90025   -32.55852 1.000 17.72884 ? 271 LEU A CD1 1 
ATOM   2088 C  CD2 . LEU A 1 271 ? 17.14166  -0.35478  -32.40640 1.000 20.93812 ? 271 LEU A CD2 1 
ATOM   2089 N  N   . LEU A 1 272 ? 14.81825  -0.96472  -37.26959 1.000 18.80981 ? 272 LEU A N   1 
ATOM   2090 C  CA  . LEU A 1 272 ? 13.91597  -1.82397  -38.03439 1.000 19.66249 ? 272 LEU A CA  1 
ATOM   2091 C  C   . LEU A 1 272 ? 14.68156  -2.89016  -38.80264 1.000 20.33289 ? 272 LEU A C   1 
ATOM   2092 O  O   . LEU A 1 272 ? 14.20056  -4.01671  -38.95409 1.000 19.11032 ? 272 LEU A O   1 
ATOM   2093 C  CB  . LEU A 1 272 ? 13.07555  -0.98078  -39.00015 1.000 17.67151 ? 272 LEU A CB  1 
ATOM   2094 C  CG  . LEU A 1 272 ? 12.18956  0.05157   -38.30396 1.000 19.73847 ? 272 LEU A CG  1 
ATOM   2095 C  CD1 . LEU A 1 272 ? 11.68774  1.11170   -39.27252 1.000 17.49805 ? 272 LEU A CD1 1 
ATOM   2096 C  CD2 . LEU A 1 272 ? 11.02334  -0.63119  -37.60654 1.000 21.70381 ? 272 LEU A CD2 1 
ATOM   2097 N  N   . GLN A 1 273 ? 15.87588  -2.55139  -39.28507 1.000 19.62656 ? 273 GLN A N   1 
ATOM   2098 C  CA  . GLN A 1 273 ? 16.69433  -3.49751  -40.03880 1.000 19.62568 ? 273 GLN A CA  1 
ATOM   2099 C  C   . GLN A 1 273 ? 17.31479  -4.55919  -39.13155 1.000 19.26829 ? 273 GLN A C   1 
ATOM   2100 O  O   . GLN A 1 273 ? 17.40170  -5.73605  -39.50555 1.000 22.21442 ? 273 GLN A O   1 
ATOM   2101 C  CB  . GLN A 1 273 ? 17.77242  -2.71300  -40.79103 1.000 16.56751 ? 273 GLN A CB  1 
ATOM   2102 C  CG  . GLN A 1 273 ? 19.01811  -3.49611  -41.19449 1.000 18.06422 ? 273 GLN A CG  1 
ATOM   2103 C  CD  . GLN A 1 273 ? 20.12265  -2.56643  -41.65179 1.000 22.51738 ? 273 GLN A CD  1 
ATOM   2104 O  OE1 . GLN A 1 273 ? 20.06001  -1.99293  -42.73973 1.000 21.82080 ? 273 GLN A OE1 1 
ATOM   2105 N  NE2 . GLN A 1 273 ? 21.12476  -2.38608  -40.80684 1.000 18.78895 ? 273 GLN A NE2 1 
ATOM   2106 N  N   . ASN A 1 274 ? 17.75221  -4.16904  -37.93722 1.000 21.49524 ? 274 ASN A N   1 
ATOM   2107 C  CA  . ASN A 1 274 ? 18.49517  -5.06668  -37.05852 1.000 23.01856 ? 274 ASN A CA  1 
ATOM   2108 C  C   . ASN A 1 274 ? 17.66318  -5.69843  -35.94906 1.000 30.56071 ? 274 ASN A C   1 
ATOM   2109 O  O   . ASN A 1 274 ? 18.04126  -6.76680  -35.45503 1.000 28.52706 ? 274 ASN A O   1 
ATOM   2110 C  CB  . ASN A 1 274 ? 19.66470  -4.32397  -36.40608 1.000 21.02619 ? 274 ASN A CB  1 
ATOM   2111 C  CG  . ASN A 1 274 ? 20.69661  -3.87054  -37.41764 1.000 21.12646 ? 274 ASN A CG  1 
ATOM   2112 O  OD1 . ASN A 1 274 ? 20.71294  -4.35096  -38.55009 1.000 21.57351 ? 274 ASN A OD1 1 
ATOM   2113 N  ND2 . ASN A 1 274 ? 21.56272  -2.94345  -37.01738 1.000 20.34246 ? 274 ASN A ND2 1 
ATOM   2114 N  N   . GLY A 1 275 ? 16.55249  -5.07903  -35.53952 1.000 27.34249 ? 275 GLY A N   1 
ATOM   2115 C  CA  . GLY A 1 275 ? 15.95094  -5.55877  -34.30726 1.000 29.04238 ? 275 GLY A CA  1 
ATOM   2116 C  C   . GLY A 1 275 ? 16.77733  -5.10877  -33.10142 1.000 30.73876 ? 275 GLY A C   1 
ATOM   2117 O  O   . GLY A 1 275 ? 17.66024  -4.25405  -33.19310 1.000 25.17184 ? 275 GLY A O   1 
ATOM   2118 N  N   . MET A 1 276 ? 16.47885  -5.71543  -31.95099 1.000 28.92232 ? 276 MET A N   1 
ATOM   2119 C  CA  . MET A 1 276 ? 17.08605  -5.30597  -30.68974 1.000 33.78584 ? 276 MET A CA  1 
ATOM   2120 C  C   . MET A 1 276 ? 18.36388  -6.06646  -30.36523 1.000 30.74902 ? 276 MET A C   1 
ATOM   2121 O  O   . MET A 1 276 ? 19.19623  -5.55670  -29.60592 1.000 31.20542 ? 276 MET A O   1 
ATOM   2122 C  CB  . MET A 1 276 ? 16.09399  -5.50235  -29.53377 1.000 34.22446 ? 276 MET A CB  1 
ATOM   2123 C  CG  . MET A 1 276 ? 14.82150  -4.66923  -29.62515 1.000 41.12399 ? 276 MET A CG  1 
ATOM   2124 S  SD  . MET A 1 276 ? 15.15238  -2.93636  -29.27410 1.000 48.41917 ? 276 MET A SD  1 
ATOM   2125 C  CE  . MET A 1 276 ? 13.54958  -2.37775  -28.70708 1.000 31.99768 ? 276 MET A CE  1 
ATOM   2126 N  N   . ASN A 1 277 ? 18.52169  -7.27149  -30.91297 1.000 31.81092 ? 277 ASN A N   1 
ATOM   2127 C  CA  . ASN A 1 277 ? 19.64266  -8.16176  -30.61640 1.000 36.08811 ? 277 ASN A CA  1 
ATOM   2128 C  C   . ASN A 1 277 ? 19.80657  -8.34333  -29.10414 1.000 35.75441 ? 277 ASN A C   1 
ATOM   2129 O  O   . ASN A 1 277 ? 20.84532  -8.04076  -28.50897 1.000 31.87600 ? 277 ASN A O   1 
ATOM   2130 C  CB  . ASN A 1 277 ? 20.93149  -7.65948  -31.27406 1.000 34.64392 ? 277 ASN A CB  1 
ATOM   2131 C  CG  . ASN A 1 277 ? 20.85325  -7.67297  -32.81001 1.000 46.46121 ? 277 ASN A CG  1 
ATOM   2132 O  OD1 . ASN A 1 277 ? 21.03320  -6.63938  -33.46403 1.000 39.12895 ? 277 ASN A OD1 1 
ATOM   2133 N  ND2 . ASN A 1 277 ? 20.58180  -8.84770  -33.38517 1.000 40.14669 ? 277 ASN A ND2 1 
ATOM   2134 N  N   . GLY A 1 278 ? 18.73898  -8.85013  -28.48997 1.000 34.90960 ? 278 GLY A N   1 
ATOM   2135 C  CA  . GLY A 1 278 ? 18.72900  -9.15511  -27.07676 1.000 29.88740 ? 278 GLY A CA  1 
ATOM   2136 C  C   . GLY A 1 278 ? 18.67373  -7.96649  -26.14602 1.000 31.96755 ? 278 GLY A C   1 
ATOM   2137 O  O   . GLY A 1 278 ? 18.64950  -8.16096  -24.92931 1.000 34.20874 ? 278 GLY A O   1 
ATOM   2138 N  N   . ARG A 1 279 ? 18.65010  -6.74634  -26.65713 1.000 30.36745 ? 279 ARG A N   1 
ATOM   2139 C  CA  . ARG A 1 279 ? 18.63875  -5.58028  -25.79313 1.000 27.79819 ? 279 ARG A CA  1 
ATOM   2140 C  C   . ARG A 1 279 ? 17.21278  -5.05682  -25.63231 1.000 26.76507 ? 279 ARG A C   1 
ATOM   2141 O  O   . ARG A 1 279 ? 16.25986  -5.55703  -26.23452 1.000 27.76069 ? 279 ARG A O   1 
ATOM   2142 C  CB  . ARG A 1 279 ? 19.57454  -4.49943  -26.33536 1.000 26.60660 ? 279 ARG A CB  1 
ATOM   2143 C  CG  . ARG A 1 279 ? 21.04617  -4.88601  -26.26757 1.000 33.90712 ? 279 ARG A CG  1 
ATOM   2144 C  CD  . ARG A 1 279 ? 21.91775  -3.97437  -27.10404 1.000 28.59780 ? 279 ARG A CD  1 
ATOM   2145 N  NE  . ARG A 1 279 ? 21.69710  -4.17634  -28.53179 1.000 37.45537 ? 279 ARG A NE  1 
ATOM   2146 C  CZ  . ARG A 1 279 ? 22.56278  -3.83599  -29.48004 1.000 41.36654 ? 279 ARG A CZ  1 
ATOM   2147 N  NH1 . ARG A 1 279 ? 23.73779  -3.29876  -29.18473 1.000 37.61186 ? 279 ARG A NH1 1 
ATOM   2148 N  NH2 . ARG A 1 279 ? 22.24336  -4.04177  -30.75624 1.000 34.35182 ? 279 ARG A NH2 1 
ATOM   2149 N  N   . THR A 1 280 ? 17.07139  -4.04714  -24.78081 1.000 25.59941 ? 280 THR A N   1 
ATOM   2150 C  CA  . THR A 1 280 ? 15.80253  -3.38889  -24.52336 1.000 30.20654 ? 280 THR A CA  1 
ATOM   2151 C  C   . THR A 1 280 ? 16.01451  -1.88648  -24.58182 1.000 30.76837 ? 280 THR A C   1 
ATOM   2152 O  O   . THR A 1 280 ? 17.13314  -1.38622  -24.42714 1.000 29.33630 ? 280 THR A O   1 
ATOM   2153 C  CB  . THR A 1 280 ? 15.20259  -3.76038  -23.14846 1.000 27.73351 ? 280 THR A CB  1 
ATOM   2154 O  OG1 . THR A 1 280 ? 16.10742  -3.37689  -22.10483 1.000 31.28627 ? 280 THR A OG1 1 
ATOM   2155 C  CG2 . THR A 1 280 ? 14.91006  -5.25421  -23.05856 1.000 24.20913 ? 280 THR A CG2 1 
ATOM   2156 N  N   . ILE A 1 281 ? 14.92248  -1.17073  -24.82406 1.000 29.42847 ? 281 ILE A N   1 
ATOM   2157 C  CA  . ILE A 1 281 ? 14.90638  0.28320   -24.75633 1.000 29.28480 ? 281 ILE A CA  1 
ATOM   2158 C  C   . ILE A 1 281 ? 13.77898  0.67109   -23.81327 1.000 28.62364 ? 281 ILE A C   1 
ATOM   2159 O  O   . ILE A 1 281 ? 12.63549  0.24226   -24.00600 1.000 25.67955 ? 281 ILE A O   1 
ATOM   2160 C  CB  . ILE A 1 281 ? 14.72549  0.92686   -26.14181 1.000 27.19275 ? 281 ILE A CB  1 
ATOM   2161 C  CG1 . ILE A 1 281 ? 15.89939  0.55957   -27.04958 1.000 23.10621 ? 281 ILE A CG1 1 
ATOM   2162 C  CG2 . ILE A 1 281 ? 14.63053  2.43678   -26.01996 1.000 25.09476 ? 281 ILE A CG2 1 
ATOM   2163 C  CD1 . ILE A 1 281 ? 15.77018  1.11467   -28.47996 1.000 27.23295 ? 281 ILE A CD1 1 
ATOM   2164 N  N   . LEU A 1 282 ? 14.11519  1.43310   -22.76729 1.000 31.44114 ? 282 LEU A N   1 
ATOM   2165 C  CA  . LEU A 1 282 ? 13.17677  1.80606   -21.70854 1.000 31.43533 ? 282 LEU A CA  1 
ATOM   2166 C  C   . LEU A 1 282 ? 12.37245  0.60022   -21.22507 1.000 32.29142 ? 282 LEU A C   1 
ATOM   2167 O  O   . LEU A 1 282 ? 11.16189  0.67853   -21.00933 1.000 31.02167 ? 282 LEU A O   1 
ATOM   2168 C  CB  . LEU A 1 282 ? 12.25289  2.93471   -22.17163 1.000 29.68606 ? 282 LEU A CB  1 
ATOM   2169 C  CG  . LEU A 1 282 ? 12.94666  4.27305   -22.43273 1.000 27.75967 ? 282 LEU A CG  1 
ATOM   2170 C  CD1 . LEU A 1 282 ? 11.96019  5.29673   -22.97277 1.000 24.68670 ? 282 LEU A CD1 1 
ATOM   2171 C  CD2 . LEU A 1 282 ? 13.64277  4.79363   -21.15985 1.000 29.58060 ? 282 LEU A CD2 1 
ATOM   2172 N  N   . GLY A 1 283 ? 13.04950  -0.53899  -21.09126 1.000 32.64800 ? 283 GLY A N   1 
ATOM   2173 C  CA  . GLY A 1 283 ? 12.41456  -1.74037  -20.59162 1.000 27.43665 ? 283 GLY A CA  1 
ATOM   2174 C  C   . GLY A 1 283 ? 11.51306  -2.46523  -21.56341 1.000 33.29644 ? 283 GLY A C   1 
ATOM   2175 O  O   . GLY A 1 283 ? 10.81520  -3.40276  -21.15567 1.000 31.58877 ? 283 GLY A O   1 
ATOM   2176 N  N   . SER A 1 284 ? 11.48797  -2.07400  -22.83201 1.000 30.22930 ? 284 SER A N   1 
ATOM   2177 C  CA  . SER A 1 284 ? 10.70199  -2.79305  -23.81937 1.000 28.20423 ? 284 SER A CA  1 
ATOM   2178 C  C   . SER A 1 284 ? 11.63293  -3.47851  -24.80617 1.000 29.54320 ? 284 SER A C   1 
ATOM   2179 O  O   . SER A 1 284 ? 12.72952  -2.99205  -25.08869 1.000 27.36715 ? 284 SER A O   1 
ATOM   2180 C  CB  . SER A 1 284 ? 9.74852   -1.86019  -24.56666 1.000 24.87039 ? 284 SER A CB  1 
ATOM   2181 O  OG  . SER A 1 284 ? 8.94794   -2.59581  -25.48960 1.000 31.14852 ? 284 SER A OG  1 
ATOM   2182 N  N   . ALA A 1 285 ? 11.19004  -4.61960  -25.32215 1.000 28.13951 ? 285 ALA A N   1 
ATOM   2183 C  CA  . ALA A 1 285 ? 11.90680  -5.30945  -26.38171 1.000 25.80801 ? 285 ALA A CA  1 
ATOM   2184 C  C   . ALA A 1 285 ? 11.25245  -5.09854  -27.74248 1.000 29.05429 ? 285 ALA A C   1 
ATOM   2185 O  O   . ALA A 1 285 ? 11.61440  -5.77833  -28.70477 1.000 32.25834 ? 285 ALA A O   1 
ATOM   2186 C  CB  . ALA A 1 285 ? 12.02241  -6.79969  -26.06092 1.000 24.98704 ? 285 ALA A CB  1 
ATOM   2187 N  N   . LEU A 1 286 ? 10.28560  -4.18436  -27.82885 1.000 27.51135 ? 286 LEU A N   1 
ATOM   2188 C  CA  . LEU A 1 286 ? 9.69550   -3.71960  -29.07505 1.000 27.23092 ? 286 LEU A CA  1 
ATOM   2189 C  C   . LEU A 1 286 ? 9.79716   -2.20122  -29.10589 1.000 26.10497 ? 286 LEU A C   1 
ATOM   2190 O  O   . LEU A 1 286 ? 10.08520  -1.55887  -28.09425 1.000 28.53995 ? 286 LEU A O   1 
ATOM   2191 C  CB  . LEU A 1 286 ? 8.22335   -4.14927  -29.21078 1.000 27.98071 ? 286 LEU A CB  1 
ATOM   2192 C  CG  . LEU A 1 286 ? 7.91874   -5.63987  -29.33916 1.000 34.33558 ? 286 LEU A CG  1 
ATOM   2193 C  CD1 . LEU A 1 286 ? 6.42354   -5.85466  -29.47684 1.000 32.96226 ? 286 LEU A CD1 1 
ATOM   2194 C  CD2 . LEU A 1 286 ? 8.66471   -6.26809  -30.51370 1.000 32.24243 ? 286 LEU A CD2 1 
ATOM   2195 N  N   . LEU A 1 287 ? 9.55496   -1.61982  -30.27458 1.000 24.08661 ? 287 LEU A N   1 
ATOM   2196 C  CA  . LEU A 1 287 ? 9.48956   -0.16836  -30.39207 1.000 23.97255 ? 287 LEU A CA  1 
ATOM   2197 C  C   . LEU A 1 287 ? 8.08570   0.29085   -29.99109 1.000 26.02121 ? 287 LEU A C   1 
ATOM   2198 O  O   . LEU A 1 287 ? 7.09447   -0.14025  -30.58440 1.000 25.48321 ? 287 LEU A O   1 
ATOM   2199 C  CB  . LEU A 1 287 ? 9.84052   0.25907   -31.81406 1.000 21.77684 ? 287 LEU A CB  1 
ATOM   2200 C  CG  . LEU A 1 287 ? 11.16705  -0.32280  -32.33619 1.000 23.72300 ? 287 LEU A CG  1 
ATOM   2201 C  CD1 . LEU A 1 287 ? 11.45091  0.11254   -33.76320 1.000 23.47825 ? 287 LEU A CD1 1 
ATOM   2202 C  CD2 . LEU A 1 287 ? 12.31321  0.06641   -31.43337 1.000 25.64832 ? 287 LEU A CD2 1 
ATOM   2203 N  N   . GLU A 1 288 ? 8.01133   1.14904   -28.97690 1.000 26.94240 ? 288 GLU A N   1 
ATOM   2204 C  CA  A GLU A 1 288 ? 6.74860   1.57549   -28.38618 0.500 23.69769 ? 288 GLU A CA  1 
ATOM   2205 C  CA  B GLU A 1 288 ? 6.74488   1.56969   -28.38924 0.500 23.71779 ? 288 GLU A CA  1 
ATOM   2206 C  C   . GLU A 1 288 ? 6.21127   2.79528   -29.12626 1.000 21.94532 ? 288 GLU A C   1 
ATOM   2207 O  O   . GLU A 1 288 ? 6.95787   3.74834   -29.38183 1.000 17.26484 ? 288 GLU A O   1 
ATOM   2208 C  CB  A GLU A 1 288 ? 6.95422   1.89624   -26.90438 0.500 24.52874 ? 288 GLU A CB  1 
ATOM   2209 C  CB  B GLU A 1 288 ? 6.92922   1.87490   -26.89995 0.500 24.54069 ? 288 GLU A CB  1 
ATOM   2210 C  CG  A GLU A 1 288 ? 5.74301   2.49141   -26.20924 0.500 26.67644 ? 288 GLU A CG  1 
ATOM   2211 C  CG  B GLU A 1 288 ? 7.43018   0.69562   -26.06099 0.500 25.43442 ? 288 GLU A CG  1 
ATOM   2212 C  CD  A GLU A 1 288 ? 4.61263   1.49472   -26.02935 0.500 27.23468 ? 288 GLU A CD  1 
ATOM   2213 C  CD  B GLU A 1 288 ? 6.39174   -0.40727  -25.89918 0.500 30.50315 ? 288 GLU A CD  1 
ATOM   2214 O  OE1 A GLU A 1 288 ? 4.89282   0.32369   -25.69546 0.500 29.84029 ? 288 GLU A OE1 1 
ATOM   2215 O  OE1 B GLU A 1 288 ? 5.18039   -0.09595  -25.87636 0.500 30.34679 ? 288 GLU A OE1 1 
ATOM   2216 O  OE2 A GLU A 1 288 ? 3.44243   1.88473   -26.22581 0.500 24.11583 ? 288 GLU A OE2 1 
ATOM   2217 O  OE2 B GLU A 1 288 ? 6.78333   -1.59168  -25.80088 0.500 31.14234 ? 288 GLU A OE2 1 
ATOM   2218 N  N   . ASP A 1 289 ? 4.91061   2.77479   -29.46766 1.000 19.94866 ? 289 ASP A N   1 
ATOM   2219 C  CA  . ASP A 1 289 ? 4.32305   3.88219   -30.22144 1.000 19.12542 ? 289 ASP A CA  1 
ATOM   2220 C  C   . ASP A 1 289 ? 3.11768   4.52633   -29.53648 1.000 22.18244 ? 289 ASP A C   1 
ATOM   2221 O  O   . ASP A 1 289 ? 2.38153   5.28817   -30.18385 1.000 17.31845 ? 289 ASP A O   1 
ATOM   2222 C  CB  . ASP A 1 289 ? 3.96116   3.45252   -31.64949 1.000 18.92921 ? 289 ASP A CB  1 
ATOM   2223 C  CG  . ASP A 1 289 ? 2.74664   2.52572   -31.73287 1.000 19.21178 ? 289 ASP A CG  1 
ATOM   2224 O  OD1 . ASP A 1 289 ? 2.28732   1.97772   -30.71474 1.000 21.62987 ? 289 ASP A OD1 1 
ATOM   2225 O  OD2 . ASP A 1 289 ? 2.26020   2.33570   -32.86658 1.000 19.56141 ? 289 ASP A OD2 1 
ATOM   2226 N  N   . GLU A 1 290 ? 2.91697   4.29605   -28.23597 1.000 19.71862 ? 290 GLU A N   1 
ATOM   2227 C  CA  . GLU A 1 290 ? 1.78949   4.91963   -27.55253 1.000 22.36460 ? 290 GLU A CA  1 
ATOM   2228 C  C   . GLU A 1 290 ? 2.23626   5.99506   -26.55407 1.000 21.86710 ? 290 GLU A C   1 
ATOM   2229 O  O   . GLU A 1 290 ? 1.57874   6.21991   -25.53862 1.000 23.78176 ? 290 GLU A O   1 
ATOM   2230 C  CB  . GLU A 1 290 ? 0.89797   3.84373   -26.91595 1.000 23.99227 ? 290 GLU A CB  1 
ATOM   2231 C  CG  . GLU A 1 290 ? 0.34336   2.86195   -27.99320 1.000 24.59081 ? 290 GLU A CG  1 
ATOM   2232 C  CD  . GLU A 1 290 ? -1.03538  2.22878   -27.69407 1.000 31.78080 ? 290 GLU A CD  1 
ATOM   2233 O  OE1 . GLU A 1 290 ? -1.41179  2.12280   -26.51183 1.000 23.02865 ? 290 GLU A OE1 1 
ATOM   2234 O  OE2 . GLU A 1 290 ? -1.74764  1.81716   -28.65686 1.000 31.28478 ? 290 GLU A OE2 1 
ATOM   2235 N  N   . PHE A 1 291 ? 3.33577   6.69437   -26.85766 1.000 19.21797 ? 291 PHE A N   1 
ATOM   2236 C  CA  . PHE A 1 291 ? 3.73672   7.93006   -26.18140 1.000 20.32768 ? 291 PHE A CA  1 
ATOM   2237 C  C   . PHE A 1 291 ? 3.87797   9.03041   -27.22847 1.000 20.52700 ? 291 PHE A C   1 
ATOM   2238 O  O   . PHE A 1 291 ? 4.67592   8.89554   -28.15637 1.000 20.24551 ? 291 PHE A O   1 
ATOM   2239 C  CB  . PHE A 1 291 ? 5.07516   7.77694   -25.44237 1.000 20.08478 ? 291 PHE A CB  1 
ATOM   2240 C  CG  . PHE A 1 291 ? 5.06005   6.77443   -24.32693 1.000 27.22338 ? 291 PHE A CG  1 
ATOM   2241 C  CD1 . PHE A 1 291 ? 4.65155   7.13758   -23.05005 1.000 28.35385 ? 291 PHE A CD1 1 
ATOM   2242 C  CD2 . PHE A 1 291 ? 5.48259   5.47610   -24.54337 1.000 26.49008 ? 291 PHE A CD2 1 
ATOM   2243 C  CE1 . PHE A 1 291 ? 4.65443   6.21165   -22.01231 1.000 32.43721 ? 291 PHE A CE1 1 
ATOM   2244 C  CE2 . PHE A 1 291 ? 5.48647   4.54722   -23.50948 1.000 30.38881 ? 291 PHE A CE2 1 
ATOM   2245 C  CZ  . PHE A 1 291 ? 5.06819   4.91372   -22.24297 1.000 28.84607 ? 291 PHE A CZ  1 
ATOM   2246 N  N   . THR A 1 292 ? 3.14012   10.12624  -27.06527 1.000 22.05739 ? 292 THR A N   1 
ATOM   2247 C  CA  . THR A 1 292 ? 3.25672   11.24424  -27.99083 1.000 20.48577 ? 292 THR A CA  1 
ATOM   2248 C  C   . THR A 1 292 ? 4.45021   12.13063  -27.63445 1.000 21.72558 ? 292 THR A C   1 
ATOM   2249 O  O   . THR A 1 292 ? 4.95171   12.08584  -26.50632 1.000 22.20501 ? 292 THR A O   1 
ATOM   2250 C  CB  . THR A 1 292 ? 1.99003   12.08946  -27.95976 1.000 21.97408 ? 292 THR A CB  1 
ATOM   2251 O  OG1 . THR A 1 292 ? 1.89925   12.74246  -26.68707 1.000 20.39003 ? 292 THR A OG1 1 
ATOM   2252 C  CG2 . THR A 1 292 ? 0.74673   11.21993  -28.18511 1.000 20.20208 ? 292 THR A CG2 1 
ATOM   2253 N  N   . PRO A 1 293 ? 4.91473   12.96382  -28.58171 1.000 16.21307 ? 293 PRO A N   1 
ATOM   2254 C  CA  . PRO A 1 293 ? 5.88706   14.00822  -28.21754 1.000 22.65100 ? 293 PRO A CA  1 
ATOM   2255 C  C   . PRO A 1 293 ? 5.48161   14.79345  -26.98263 1.000 25.80315 ? 293 PRO A C   1 
ATOM   2256 O  O   . PRO A 1 293 ? 6.32390   15.08273  -26.12420 1.000 24.37797 ? 293 PRO A O   1 
ATOM   2257 C  CB  . PRO A 1 293 ? 5.92360   14.88798  -29.47104 1.000 17.98101 ? 293 PRO A CB  1 
ATOM   2258 C  CG  . PRO A 1 293 ? 5.65653   13.92880  -30.58363 1.000 20.13842 ? 293 PRO A CG  1 
ATOM   2259 C  CD  . PRO A 1 293 ? 4.67374   12.92408  -30.03879 1.000 19.57780 ? 293 PRO A CD  1 
ATOM   2260 N  N   . PHE A 1 294 ? 4.19605   15.12382  -26.86482 1.000 25.87767 ? 294 PHE A N   1 
ATOM   2261 C  CA  . PHE A 1 294 ? 3.71110   15.86131  -25.70214 1.000 25.54645 ? 294 PHE A CA  1 
ATOM   2262 C  C   . PHE A 1 294 ? 3.85219   15.03074  -24.42781 1.000 26.66507 ? 294 PHE A C   1 
ATOM   2263 O  O   . PHE A 1 294 ? 4.29682   15.53536  -23.39022 1.000 28.25416 ? 294 PHE A O   1 
ATOM   2264 C  CB  . PHE A 1 294 ? 2.25812   16.26926  -25.94767 1.000 28.27684 ? 294 PHE A CB  1 
ATOM   2265 C  CG  . PHE A 1 294 ? 1.68658   17.19621  -24.90749 1.000 34.06262 ? 294 PHE A CG  1 
ATOM   2266 C  CD1 . PHE A 1 294 ? 1.11925   16.69549  -23.74518 1.000 35.03687 ? 294 PHE A CD1 1 
ATOM   2267 C  CD2 . PHE A 1 294 ? 1.67746   18.56902  -25.11468 1.000 39.65912 ? 294 PHE A CD2 1 
ATOM   2268 C  CE1 . PHE A 1 294 ? 0.58024   17.55104  -22.78556 1.000 42.69780 ? 294 PHE A CE1 1 
ATOM   2269 C  CE2 . PHE A 1 294 ? 1.13473   19.43052  -24.16577 1.000 45.00830 ? 294 PHE A CE2 1 
ATOM   2270 C  CZ  . PHE A 1 294 ? 0.58710   18.91938  -23.00004 1.000 43.17471 ? 294 PHE A CZ  1 
ATOM   2271 N  N   . ASP A 1 295 ? 3.48386   13.74579  -24.49312 1.000 22.89676 ? 295 ASP A N   1 
ATOM   2272 C  CA  . ASP A 1 295 ? 3.63195   12.86022  -23.34108 1.000 21.75079 ? 295 ASP A CA  1 
ATOM   2273 C  C   . ASP A 1 295 ? 5.08028   12.79204  -22.86737 1.000 30.84104 ? 295 ASP A C   1 
ATOM   2274 O  O   . ASP A 1 295 ? 5.34459   12.80079  -21.65719 1.000 30.44062 ? 295 ASP A O   1 
ATOM   2275 C  CB  . ASP A 1 295 ? 3.15230   11.44446  -23.67656 1.000 19.47385 ? 295 ASP A CB  1 
ATOM   2276 C  CG  . ASP A 1 295 ? 1.66246   11.36811  -23.99459 1.000 27.51698 ? 295 ASP A CG  1 
ATOM   2277 O  OD1 . ASP A 1 295 ? 0.90543   12.30622  -23.65419 1.000 27.05326 ? 295 ASP A OD1 1 
ATOM   2278 O  OD2 . ASP A 1 295 ? 1.25317   10.34609  -24.58539 1.000 23.87200 ? 295 ASP A OD2 1 
ATOM   2279 N  N   . VAL A 1 296 ? 6.02942   12.68771  -23.80646 1.000 27.80217 ? 296 VAL A N   1 
ATOM   2280 C  CA  . VAL A 1 296 ? 7.42820   12.47116  -23.43847 1.000 28.65859 ? 296 VAL A CA  1 
ATOM   2281 C  C   . VAL A 1 296 ? 7.96263   13.67485  -22.67733 1.000 34.13741 ? 296 VAL A C   1 
ATOM   2282 O  O   . VAL A 1 296 ? 8.58859   13.53775  -21.61756 1.000 35.11001 ? 296 VAL A O   1 
ATOM   2283 C  CB  . VAL A 1 296 ? 8.27618   12.16118  -24.68787 1.000 22.33479 ? 296 VAL A CB  1 
ATOM   2284 C  CG1 . VAL A 1 296 ? 9.74964   12.37610  -24.41123 1.000 24.52015 ? 296 VAL A CG1 1 
ATOM   2285 C  CG2 . VAL A 1 296 ? 8.04554   10.72429  -25.13178 1.000 24.28893 ? 296 VAL A CG2 1 
ATOM   2286 N  N   . VAL A 1 297 ? 7.71278   14.87465  -23.20409 1.000 32.10391 ? 297 VAL A N   1 
ATOM   2287 C  CA  . VAL A 1 297 ? 8.03699   16.09381  -22.46862 1.000 36.14237 ? 297 VAL A CA  1 
ATOM   2288 C  C   . VAL A 1 297 ? 7.37069   16.08860  -21.09220 1.000 40.23004 ? 297 VAL A C   1 
ATOM   2289 O  O   . VAL A 1 297 ? 7.98745   16.46170  -20.08603 1.000 38.00852 ? 297 VAL A O   1 
ATOM   2290 C  CB  . VAL A 1 297 ? 7.63283   17.33036  -23.29183 1.000 36.28469 ? 297 VAL A CB  1 
ATOM   2291 C  CG1 . VAL A 1 297 ? 7.96887   18.59981  -22.53461 1.000 36.51817 ? 297 VAL A CG1 1 
ATOM   2292 C  CG2 . VAL A 1 297 ? 8.31750   17.30858  -24.65764 1.000 32.41191 ? 297 VAL A CG2 1 
ATOM   2293 N  N   . ARG A 1 298 ? 6.11116   15.64723  -21.02256 1.000 36.20962 ? 298 ARG A N   1 
ATOM   2294 C  CA  . ARG A 1 298 ? 5.37374   15.67685  -19.75847 1.000 39.16476 ? 298 ARG A CA  1 
ATOM   2295 C  C   . ARG A 1 298 ? 6.05684   14.82281  -18.69362 1.000 39.84883 ? 298 ARG A C   1 
ATOM   2296 O  O   . ARG A 1 298 ? 6.28724   15.27993  -17.57051 1.000 45.11388 ? 298 ARG A O   1 
ATOM   2297 C  CB  . ARG A 1 298 ? 3.92833   15.21446  -19.98888 1.000 36.63868 ? 298 ARG A CB  1 
ATOM   2298 C  CG  . ARG A 1 298 ? 3.18763   14.65729  -18.75799 1.000 44.86370 ? 298 ARG A CG  1 
ATOM   2299 C  CD  . ARG A 1 298 ? 2.08891   13.65037  -19.18031 1.000 51.60220 ? 298 ARG A CD  1 
ATOM   2300 N  NE  . ARG A 1 298 ? 1.35731   13.05798  -18.06037 1.000 50.71353 ? 298 ARG A NE  1 
ATOM   2301 C  CZ  . ARG A 1 298 ? 0.55495   12.00151  -18.15128 1.000 34.58072 ? 298 ARG A CZ  1 
ATOM   2302 N  NH1 . ARG A 1 298 ? 0.36606   11.36871  -19.29691 1.000 37.52430 ? 298 ARG A NH1 1 
ATOM   2303 N  NH2 . ARG A 1 298 ? -0.07664  11.57033  -17.06318 1.000 38.71592 ? 298 ARG A NH2 1 
ATOM   2304 N  N   . GLN A 1 299 ? 6.40707   13.58285  -19.03516 1.000 39.99984 ? 299 GLN A N   1 
ATOM   2305 C  CA  . GLN A 1 299 ? 6.90050   12.63977  -18.03687 1.000 38.93260 ? 299 GLN A CA  1 
ATOM   2306 C  C   . GLN A 1 299 ? 8.38210   12.83368  -17.72983 1.000 47.79686 ? 299 GLN A C   1 
ATOM   2307 O  O   . GLN A 1 299 ? 8.82335   12.53101  -16.61451 1.000 52.11124 ? 299 GLN A O   1 
ATOM   2308 C  CB  . GLN A 1 299 ? 6.63919   11.20548  -18.50975 1.000 41.02604 ? 299 GLN A CB  1 
ATOM   2309 C  CG  . GLN A 1 299 ? 7.05113   10.11769  -17.52114 1.000 43.24896 ? 299 GLN A CG  1 
ATOM   2310 C  CD  . GLN A 1 299 ? 6.55298   8.73840   -17.92977 1.000 42.99430 ? 299 GLN A CD  1 
ATOM   2311 O  OE1 . GLN A 1 299 ? 6.90941   7.72780   -17.32236 1.000 36.66126 ? 299 GLN A OE1 1 
ATOM   2312 N  NE2 . GLN A 1 299 ? 5.71943   8.69395   -18.96272 1.000 37.90087 ? 299 GLN A NE2 1 
ATOM   2313 N  N   . CYS A 1 300 ? 9.15839   13.34282  -18.68519 1.000 48.86851 ? 300 CYS A N   1 
ATOM   2314 C  CA  . CYS A 1 300 ? 10.60084  13.47388  -18.52288 1.000 50.77218 ? 300 CYS A CA  1 
ATOM   2315 C  C   . CYS A 1 300 ? 11.02631  14.80280  -17.91611 1.000 53.82726 ? 300 CYS A C   1 
ATOM   2316 O  O   . CYS A 1 300 ? 12.19435  14.94141  -17.53696 1.000 60.63757 ? 300 CYS A O   1 
ATOM   2317 C  CB  . CYS A 1 300 ? 11.30647  13.29702  -19.87538 1.000 45.42528 ? 300 CYS A CB  1 
ATOM   2318 S  SG  . CYS A 1 300 ? 11.15795  11.64053  -20.57870 1.000 46.97652 ? 300 CYS A SG  1 
ATOM   2319 N  N   . SER A 1 301 ? 10.12402  15.77343  -17.80797 1.000 53.30206 ? 301 SER A N   1 
ATOM   2320 C  CA  . SER A 1 301 ? 10.51434  17.11713  -17.38800 1.000 53.44630 ? 301 SER A CA  1 
ATOM   2321 C  C   . SER A 1 301 ? 9.47417   17.77512  -16.47917 1.000 57.04457 ? 301 SER A C   1 
ATOM   2322 O  O   . SER A 1 301 ? 8.34252   17.30031  -16.35744 1.000 53.06042 ? 301 SER A O   1 
ATOM   2323 C  CB  . SER A 1 301 ? 10.76530  17.99259  -18.62077 1.000 53.64811 ? 301 SER A CB  1 
ATOM   2324 O  OG  . SER A 1 301 ? 11.62337  17.33829  -19.54823 1.000 48.65831 ? 301 SER A OG  1 
ATOM   2325 N  N   . SER B 1 1   ? -12.45892 -8.52149  -24.54292 1.000 24.58016 ? 1   SER B N   1 
ATOM   2326 C  CA  . SER B 1 1   ? -11.12156 -8.96002  -24.93542 1.000 27.80291 ? 1   SER B CA  1 
ATOM   2327 C  C   . SER B 1 1   ? -10.09828 -7.85043  -24.74592 1.000 26.31521 ? 1   SER B C   1 
ATOM   2328 O  O   . SER B 1 1   ? -10.45025 -6.67675  -24.60057 1.000 23.48350 ? 1   SER B O   1 
ATOM   2329 C  CB  . SER B 1 1   ? -11.09807 -9.42319  -26.39505 1.000 28.51591 ? 1   SER B CB  1 
ATOM   2330 O  OG  . SER B 1 1   ? -12.04222 -10.45646 -26.62124 1.000 38.07807 ? 1   SER B OG  1 
ATOM   2331 N  N   . GLY B 1 2   ? -8.82896  -8.23299  -24.77847 1.000 24.18851 ? 2   GLY B N   1 
ATOM   2332 C  CA  . GLY B 1 2   ? -7.74804  -7.30786  -24.52674 1.000 24.99489 ? 2   GLY B CA  1 
ATOM   2333 C  C   . GLY B 1 2   ? -7.20612  -7.44950  -23.11479 1.000 23.44493 ? 2   GLY B C   1 
ATOM   2334 O  O   . GLY B 1 2   ? -7.87730  -7.92927  -22.19853 1.000 25.79653 ? 2   GLY B O   1 
ATOM   2335 N  N   . PHE B 1 3   ? -5.96639  -7.00950  -22.93834 1.000 21.32149 ? 3   PHE B N   1 
ATOM   2336 C  CA  . PHE B 1 3   ? -5.31175  -7.11008  -21.64212 1.000 23.94609 ? 3   PHE B CA  1 
ATOM   2337 C  C   . PHE B 1 3   ? -4.31168  -5.97341  -21.53626 1.000 23.05845 ? 3   PHE B C   1 
ATOM   2338 O  O   . PHE B 1 3   ? -3.41026  -5.85997  -22.37057 1.000 24.92873 ? 3   PHE B O   1 
ATOM   2339 C  CB  . PHE B 1 3   ? -4.62832  -8.46926  -21.46458 1.000 23.36317 ? 3   PHE B CB  1 
ATOM   2340 C  CG  . PHE B 1 3   ? -4.37192  -8.83069  -20.03370 1.000 21.57674 ? 3   PHE B CG  1 
ATOM   2341 C  CD1 . PHE B 1 3   ? -5.41977  -9.19376  -19.19956 1.000 24.30299 ? 3   PHE B CD1 1 
ATOM   2342 C  CD2 . PHE B 1 3   ? -3.08572  -8.79627  -19.51688 1.000 23.54959 ? 3   PHE B CD2 1 
ATOM   2343 C  CE1 . PHE B 1 3   ? -5.19595  -9.52309  -17.87130 1.000 22.98806 ? 3   PHE B CE1 1 
ATOM   2344 C  CE2 . PHE B 1 3   ? -2.85251  -9.12554  -18.19379 1.000 25.41335 ? 3   PHE B CE2 1 
ATOM   2345 C  CZ  . PHE B 1 3   ? -3.91451  -9.48534  -17.36868 1.000 24.37559 ? 3   PHE B CZ  1 
ATOM   2346 N  N   . ARG B 1 4   ? -4.49194  -5.13363  -20.52597 1.000 21.56177 ? 4   ARG B N   1 
ATOM   2347 C  CA  . ARG B 1 4   ? -3.69532  -3.93631  -20.31681 1.000 21.10737 ? 4   ARG B CA  1 
ATOM   2348 C  C   . ARG B 1 4   ? -3.14720  -3.93549  -18.90002 1.000 19.08885 ? 4   ARG B C   1 
ATOM   2349 O  O   . ARG B 1 4   ? -3.71955  -4.54173  -17.98983 1.000 19.52604 ? 4   ARG B O   1 
ATOM   2350 C  CB  . ARG B 1 4   ? -4.52485  -2.66001  -20.52041 1.000 23.05809 ? 4   ARG B CB  1 
ATOM   2351 C  CG  . ARG B 1 4   ? -4.84573  -2.33040  -21.95896 1.000 25.42556 ? 4   ARG B CG  1 
ATOM   2352 C  CD  . ARG B 1 4   ? -3.76536  -1.42629  -22.50146 1.000 23.36613 ? 4   ARG B CD  1 
ATOM   2353 N  NE  . ARG B 1 4   ? -3.97642  -1.03385  -23.88804 1.000 20.59455 ? 4   ARG B NE  1 
ATOM   2354 C  CZ  . ARG B 1 4   ? -3.11197  -0.29922  -24.57498 1.000 23.77306 ? 4   ARG B CZ  1 
ATOM   2355 N  NH1 . ARG B 1 4   ? -1.99278  0.14048   -24.02192 1.000 19.52728 ? 4   ARG B NH1 1 
ATOM   2356 N  NH2 . ARG B 1 4   ? -3.37245  -0.00299  -25.84625 1.000 23.74713 ? 4   ARG B NH2 1 
ATOM   2357 N  N   . LYS B 1 5   ? -2.03479  -3.22810  -18.72314 1.000 20.18885 ? 5   LYS B N   1 
ATOM   2358 C  CA  . LYS B 1 5   ? -1.51143  -2.93734  -17.39490 1.000 22.95445 ? 5   LYS B CA  1 
ATOM   2359 C  C   . LYS B 1 5   ? -2.42170  -1.89452  -16.76021 1.000 23.50841 ? 5   LYS B C   1 
ATOM   2360 O  O   . LYS B 1 5   ? -2.37246  -0.71005  -17.09277 1.000 28.21272 ? 5   LYS B O   1 
ATOM   2361 C  CB  . LYS B 1 5   ? -0.06872  -2.45165  -17.46909 1.000 20.82934 ? 5   LYS B CB  1 
ATOM   2362 C  CG  . LYS B 1 5   ? 0.57881   -2.29924  -16.10211 1.000 27.68558 ? 5   LYS B CG  1 
ATOM   2363 C  CD  . LYS B 1 5   ? 2.08624   -2.47772  -16.19446 1.000 33.60394 ? 5   LYS B CD  1 
ATOM   2364 C  CE  . LYS B 1 5   ? 2.44770   -3.85516  -16.73686 1.000 32.52382 ? 5   LYS B CE  1 
ATOM   2365 N  NZ  . LYS B 1 5   ? 3.90938   -3.98510  -17.01106 1.000 32.08326 ? 5   LYS B NZ  1 
ATOM   2366 N  N   . MET B 1 6   ? -3.25591  -2.33453  -15.83807 1.000 20.90979 ? 6   MET B N   1 
ATOM   2367 C  CA  . MET B 1 6   ? -4.37764  -1.54758  -15.35649 1.000 26.51792 ? 6   MET B CA  1 
ATOM   2368 C  C   . MET B 1 6   ? -4.12716  -1.12926  -13.91568 1.000 19.76851 ? 6   MET B C   1 
ATOM   2369 O  O   . MET B 1 6   ? -3.79864  -1.96399  -13.07216 1.000 17.18345 ? 6   MET B O   1 
ATOM   2370 C  CB  . MET B 1 6   ? -5.66293  -2.36604  -15.46570 1.000 21.75401 ? 6   MET B CB  1 
ATOM   2371 C  CG  . MET B 1 6   ? -6.92460  -1.58116  -15.32761 1.000 27.46536 ? 6   MET B CG  1 
ATOM   2372 S  SD  . MET B 1 6   ? -8.30671  -2.63889  -15.79175 1.000 34.94692 ? 6   MET B SD  1 
ATOM   2373 C  CE  . MET B 1 6   ? -8.04624  -2.81141  -17.54131 1.000 25.11569 ? 6   MET B CE  1 
ATOM   2374 N  N   . ALA B 1 7   ? -4.29228  0.15396   -13.63762 1.000 18.21612 ? 7   ALA B N   1 
ATOM   2375 C  CA  . ALA B 1 7   ? -4.20040  0.67575   -12.28448 1.000 15.51670 ? 7   ALA B CA  1 
ATOM   2376 C  C   . ALA B 1 7   ? -5.58919  0.76787   -11.66757 1.000 17.00291 ? 7   ALA B C   1 
ATOM   2377 O  O   . ALA B 1 7   ? -6.59819  0.82639   -12.37063 1.000 18.08613 ? 7   ALA B O   1 
ATOM   2378 C  CB  . ALA B 1 7   ? -3.53627  2.05452   -12.27813 1.000 16.88604 ? 7   ALA B CB  1 
ATOM   2379 N  N   . PHE B 1 8   ? -5.63148  0.76665   -10.33801 1.000 17.70077 ? 8   PHE B N   1 
ATOM   2380 C  CA  . PHE B 1 8   ? -6.88973  1.02131   -9.65302  1.000 18.12687 ? 8   PHE B CA  1 
ATOM   2381 C  C   . PHE B 1 8   ? -7.36994  2.43775   -9.94812  1.000 18.44667 ? 8   PHE B C   1 
ATOM   2382 O  O   . PHE B 1 8   ? -6.55894  3.33561   -10.21084 1.000 17.20683 ? 8   PHE B O   1 
ATOM   2383 C  CB  . PHE B 1 8   ? -6.74309  0.84644   -8.14127  1.000 17.74569 ? 8   PHE B CB  1 
ATOM   2384 C  CG  . PHE B 1 8   ? -6.60586  -0.57953  -7.71197  1.000 18.49368 ? 8   PHE B CG  1 
ATOM   2385 C  CD1 . PHE B 1 8   ? -7.72609  -1.37035  -7.53796  1.000 23.51882 ? 8   PHE B CD1 1 
ATOM   2386 C  CD2 . PHE B 1 8   ? -5.35751  -1.13336  -7.49594  1.000 22.07134 ? 8   PHE B CD2 1 
ATOM   2387 C  CE1 . PHE B 1 8   ? -7.60245  -2.69555  -7.15896  1.000 28.90407 ? 8   PHE B CE1 1 
ATOM   2388 C  CE2 . PHE B 1 8   ? -5.22835  -2.46202  -7.12079  1.000 25.51842 ? 8   PHE B CE2 1 
ATOM   2389 C  CZ  . PHE B 1 8   ? -6.34990  -3.23947  -6.94515  1.000 23.35285 ? 8   PHE B CZ  1 
ATOM   2390 N  N   . PRO B 1 9   ? -8.68235  2.66726   -9.89931  1.000 19.50373 ? 9   PRO B N   1 
ATOM   2391 C  CA  . PRO B 1 9   ? -9.17627  4.04710   -9.90417  1.000 19.46962 ? 9   PRO B CA  1 
ATOM   2392 C  C   . PRO B 1 9   ? -8.56580  4.77774   -8.71930  1.000 19.79634 ? 9   PRO B C   1 
ATOM   2393 O  O   . PRO B 1 9   ? -8.51660  4.25004   -7.61022  1.000 22.00407 ? 9   PRO B O   1 
ATOM   2394 C  CB  . PRO B 1 9   ? -10.69969 3.89512   -9.76722  1.000 21.67820 ? 9   PRO B CB  1 
ATOM   2395 C  CG  . PRO B 1 9   ? -10.99999 2.43507   -10.02822 1.000 22.52545 ? 9   PRO B CG  1 
ATOM   2396 C  CD  . PRO B 1 9   ? -9.75197  1.68504   -9.65334  1.000 19.87633 ? 9   PRO B CD  1 
ATOM   2397 N  N   . SER B 1 10  ? -8.04808  5.97365   -8.97344  1.000 19.89765 ? 10  SER B N   1 
ATOM   2398 C  CA  . SER B 1 10  ? -7.22501  6.67520   -7.99897  1.000 18.34183 ? 10  SER B CA  1 
ATOM   2399 C  C   . SER B 1 10  ? -7.97503  7.76461   -7.24513  1.000 22.47561 ? 10  SER B C   1 
ATOM   2400 O  O   . SER B 1 10  ? -7.35469  8.48088   -6.45557  1.000 20.95158 ? 10  SER B O   1 
ATOM   2401 C  CB  . SER B 1 10  ? -5.99947  7.28625   -8.68398  1.000 18.06811 ? 10  SER B CB  1 
ATOM   2402 O  OG  . SER B 1 10  ? -6.37148  8.25277   -9.65594  1.000 20.00179 ? 10  SER B OG  1 
ATOM   2403 N  N   . GLY B 1 11  ? -9.28811  7.89027   -7.45378  1.000 21.33457 ? 11  GLY B N   1 
ATOM   2404 C  CA  . GLY B 1 11  ? -10.01578 9.02709   -6.90879  1.000 20.73050 ? 11  GLY B CA  1 
ATOM   2405 C  C   . GLY B 1 11  ? -9.97134  9.10186   -5.39399  1.000 22.66594 ? 11  GLY B C   1 
ATOM   2406 O  O   . GLY B 1 11  ? -9.72685  10.16591  -4.82323  1.000 22.88927 ? 11  GLY B O   1 
ATOM   2407 N  N   . LYS B 1 12  ? -10.20872 7.97249   -4.71866  1.000 20.06769 ? 12  LYS B N   1 
ATOM   2408 C  CA  . LYS B 1 12  ? -10.16049 7.96553   -3.25708  1.000 20.34905 ? 12  LYS B CA  1 
ATOM   2409 C  C   . LYS B 1 12  ? -8.82080  8.46384   -2.71545  1.000 22.95465 ? 12  LYS B C   1 
ATOM   2410 O  O   . LYS B 1 12  ? -8.77353  9.07575   -1.64226  1.000 21.47012 ? 12  LYS B O   1 
ATOM   2411 C  CB  . LYS B 1 12  ? -10.44754 6.55977   -2.73581  1.000 21.90319 ? 12  LYS B CB  1 
ATOM   2412 C  CG  . LYS B 1 12  ? -11.89437 6.12266   -2.92354  1.000 23.41349 ? 12  LYS B CG  1 
ATOM   2413 C  CD  . LYS B 1 12  ? -12.07993 4.66253   -2.53698  1.000 29.80244 ? 12  LYS B CD  1 
ATOM   2414 C  CE  . LYS B 1 12  ? -13.49811 4.36770   -2.03813  1.000 34.44110 ? 12  LYS B CE  1 
ATOM   2415 N  NZ  . LYS B 1 12  ? -14.53321 4.49027   -3.09766  1.000 42.12731 ? 12  LYS B NZ  1 
ATOM   2416 N  N   . VAL B 1 13  ? -7.73187  8.23936   -3.44686  1.000 18.22302 ? 13  VAL B N   1 
ATOM   2417 C  CA  . VAL B 1 13  ? -6.40651  8.64494   -2.98889  1.000 19.16560 ? 13  VAL B CA  1 
ATOM   2418 C  C   . VAL B 1 13  ? -6.10639  10.09436  -3.35734  1.000 21.68051 ? 13  VAL B C   1 
ATOM   2419 O  O   . VAL B 1 13  ? -5.45987  10.81021  -2.58471  1.000 21.65031 ? 13  VAL B O   1 
ATOM   2420 C  CB  . VAL B 1 13  ? -5.34071  7.67985   -3.55369  1.000 19.16787 ? 13  VAL B CB  1 
ATOM   2421 C  CG1 . VAL B 1 13  ? -3.92772  8.14638   -3.18641  1.000 17.23745 ? 13  VAL B CG1 1 
ATOM   2422 C  CG2 . VAL B 1 13  ? -5.58900  6.28227   -3.03378  1.000 17.86141 ? 13  VAL B CG2 1 
ATOM   2423 N  N   . GLU B 1 14  ? -6.57275  10.54604  -4.53015  1.000 19.20075 ? 14  GLU B N   1 
ATOM   2424 C  CA  . GLU B 1 14  ? -6.34477  11.93080  -4.94222  1.000 21.91443 ? 14  GLU B CA  1 
ATOM   2425 C  C   . GLU B 1 14  ? -6.80869  12.91128  -3.86672  1.000 19.17197 ? 14  GLU B C   1 
ATOM   2426 O  O   . GLU B 1 14  ? -6.12406  13.89538  -3.57475  1.000 23.65597 ? 14  GLU B O   1 
ATOM   2427 C  CB  . GLU B 1 14  ? -7.06576  12.21140  -6.26963  1.000 20.87588 ? 14  GLU B CB  1 
ATOM   2428 C  CG  . GLU B 1 14  ? -6.55316  11.40451  -7.47201  1.000 20.37646 ? 14  GLU B CG  1 
ATOM   2429 C  CD  . GLU B 1 14  ? -7.51680  11.44572  -8.66673  1.000 23.05709 ? 14  GLU B CD  1 
ATOM   2430 O  OE1 . GLU B 1 14  ? -7.94938  12.55543  -9.04187  1.000 22.25783 ? 14  GLU B OE1 1 
ATOM   2431 O  OE2 . GLU B 1 14  ? -7.85007  10.37347  -9.22422  1.000 19.80290 ? 14  GLU B OE2 1 
ATOM   2432 N  N   . GLY B 1 15  ? -7.96284  12.65238  -3.25905  1.000 19.72062 ? 15  GLY B N   1 
ATOM   2433 C  CA  . GLY B 1 15  ? -8.48441  13.52581  -2.22207  1.000 22.92488 ? 15  GLY B CA  1 
ATOM   2434 C  C   . GLY B 1 15  ? -7.70629  13.59022  -0.91737  1.000 24.88276 ? 15  GLY B C   1 
ATOM   2435 O  O   . GLY B 1 15  ? -8.09788  14.32876  -0.00683  1.000 22.72491 ? 15  GLY B O   1 
ATOM   2436 N  N   . CYS B 1 16  ? -6.60929  12.83348  -0.80975  1.000 21.21768 ? 16  CYS B N   1 
ATOM   2437 C  CA  . CYS B 1 16  ? -5.77983  12.81866  0.38542   1.000 21.22936 ? 16  CYS B CA  1 
ATOM   2438 C  C   . CYS B 1 16  ? -4.41408  13.45647  0.19411   1.000 20.20817 ? 16  CYS B C   1 
ATOM   2439 O  O   . CYS B 1 16  ? -3.66619  13.55297  1.16743   1.000 21.73936 ? 16  CYS B O   1 
ATOM   2440 C  CB  . CYS B 1 16  ? -5.57616  11.38342  0.88153   1.000 17.85440 ? 16  CYS B CB  1 
ATOM   2441 S  SG  . CYS B 1 16  ? -7.10645  10.46131  1.05712   1.000 22.63825 ? 16  CYS B SG  1 
ATOM   2442 N  N   . MET B 1 17  ? -4.05602  13.87567  -1.01946  1.000 22.72508 ? 17  MET B N   1 
ATOM   2443 C  CA  . MET B 1 17  ? -2.71101  14.36429  -1.29598  1.000 17.11822 ? 17  MET B CA  1 
ATOM   2444 C  C   . MET B 1 17  ? -2.59550  15.84488  -0.95984  1.000 23.01720 ? 17  MET B C   1 
ATOM   2445 O  O   . MET B 1 17  ? -3.45358  16.65337  -1.31955  1.000 21.59633 ? 17  MET B O   1 
ATOM   2446 C  CB  . MET B 1 17  ? -2.31765  14.14930  -2.76034  1.000 21.94035 ? 17  MET B CB  1 
ATOM   2447 C  CG  . MET B 1 17  ? -2.32733  12.69258  -3.23157  1.000 23.96318 ? 17  MET B CG  1 
ATOM   2448 S  SD  . MET B 1 17  ? -1.52338  11.55297  -2.08547  1.000 20.22941 ? 17  MET B SD  1 
ATOM   2449 C  CE  . MET B 1 17  ? 0.13478   12.24132  -1.97938  1.000 20.12313 ? 17  MET B CE  1 
ATOM   2450 N  N   . VAL B 1 18  ? -1.51210  16.19664  -0.27592  1.000 24.71296 ? 18  VAL B N   1 
ATOM   2451 C  CA  . VAL B 1 18  ? -1.24643  17.56885  0.13073   1.000 24.62180 ? 18  VAL B CA  1 
ATOM   2452 C  C   . VAL B 1 18  ? 0.22663   17.85732  -0.11475  1.000 23.33588 ? 18  VAL B C   1 
ATOM   2453 O  O   . VAL B 1 18  ? 1.02142   16.96199  -0.40493  1.000 22.83520 ? 18  VAL B O   1 
ATOM   2454 C  CB  . VAL B 1 18  ? -1.59879  17.82785  1.61123   1.000 22.72994 ? 18  VAL B CB  1 
ATOM   2455 C  CG1 . VAL B 1 18  ? -3.04963  17.48725  1.88438   1.000 22.96197 ? 18  VAL B CG1 1 
ATOM   2456 C  CG2 . VAL B 1 18  ? -0.67600  17.03627  2.51255   1.000 23.19826 ? 18  VAL B CG2 1 
ATOM   2457 N  N   . GLN B 1 19  ? 0.58366   19.12566  0.02542   1.000 26.70491 ? 19  GLN B N   1 
ATOM   2458 C  CA  . GLN B 1 19  ? 1.95352   19.58758  -0.12369  1.000 25.55032 ? 19  GLN B CA  1 
ATOM   2459 C  C   . GLN B 1 19  ? 2.52851   19.86991  1.25559   1.000 27.16225 ? 19  GLN B C   1 
ATOM   2460 O  O   . GLN B 1 19  ? 1.86819   20.50057  2.08624   1.000 31.26926 ? 19  GLN B O   1 
ATOM   2461 C  CB  . GLN B 1 19  ? 2.00045   20.85064  -0.98747  1.000 31.28436 ? 19  GLN B CB  1 
ATOM   2462 C  CG  . GLN B 1 19  ? 3.39986   21.30218  -1.36487  1.000 36.80855 ? 19  GLN B CG  1 
ATOM   2463 C  CD  . GLN B 1 19  ? 3.39914   22.61581  -2.13223  1.000 40.94839 ? 19  GLN B CD  1 
ATOM   2464 O  OE1 . GLN B 1 19  ? 4.35958   22.94086  -2.82688  1.000 46.13117 ? 19  GLN B OE1 1 
ATOM   2465 N  NE2 . GLN B 1 19  ? 2.31748   23.37777  -2.00446  1.000 43.82911 ? 19  GLN B NE2 1 
ATOM   2466 N  N   . VAL B 1 20  ? 3.74822   19.40013  1.49794   1.000 26.74648 ? 20  VAL B N   1 
ATOM   2467 C  CA  . VAL B 1 20  ? 4.45188   19.63115  2.75398   1.000 29.89922 ? 20  VAL B CA  1 
ATOM   2468 C  C   . VAL B 1 20  ? 5.76341   20.32349  2.43145   1.000 33.87607 ? 20  VAL B C   1 
ATOM   2469 O  O   . VAL B 1 20  ? 6.52303   19.86020  1.57106   1.000 35.08855 ? 20  VAL B O   1 
ATOM   2470 C  CB  . VAL B 1 20  ? 4.70534   18.32871  3.53542   1.000 25.96446 ? 20  VAL B CB  1 
ATOM   2471 C  CG1 . VAL B 1 20  ? 5.46537   18.62536  4.81390   1.000 30.33143 ? 20  VAL B CG1 1 
ATOM   2472 C  CG2 . VAL B 1 20  ? 3.38864   17.63576  3.86482   1.000 27.97926 ? 20  VAL B CG2 1 
ATOM   2473 N  N   . THR B 1 21  ? 6.01837   21.43591  3.10617   1.000 38.68093 ? 21  THR B N   1 
ATOM   2474 C  CA  . THR B 1 21  ? 7.25657   22.18060  2.95044   1.000 38.53531 ? 21  THR B CA  1 
ATOM   2475 C  C   . THR B 1 21  ? 7.91522   22.34044  4.30977   1.000 37.79557 ? 21  THR B C   1 
ATOM   2476 O  O   . THR B 1 21  ? 7.23891   22.59584  5.31259   1.000 37.71052 ? 21  THR B O   1 
ATOM   2477 C  CB  . THR B 1 21  ? 7.00961   23.55843  2.32265   1.000 42.12329 ? 21  THR B CB  1 
ATOM   2478 O  OG1 . THR B 1 21  ? 6.39341   23.40073  1.03953   1.000 37.24169 ? 21  THR B OG1 1 
ATOM   2479 C  CG2 . THR B 1 21  ? 8.32128   24.30250  2.14965   1.000 43.50577 ? 21  THR B CG2 1 
ATOM   2480 N  N   . CYS B 1 22  ? 9.23304   22.15237  4.33838   1.000 39.95501 ? 22  CYS B N   1 
ATOM   2481 C  CA  . CYS B 1 22  ? 10.04393  22.41322  5.52451   1.000 43.13538 ? 22  CYS B CA  1 
ATOM   2482 C  C   . CYS B 1 22  ? 11.35844  22.99937  5.03247   1.000 42.97289 ? 22  CYS B C   1 
ATOM   2483 O  O   . CYS B 1 22  ? 12.11389  22.32747  4.32313   1.000 38.02296 ? 22  CYS B O   1 
ATOM   2484 C  CB  . CYS B 1 22  ? 10.26867  21.14309  6.35051   1.000 41.77702 ? 22  CYS B CB  1 
ATOM   2485 S  SG  . CYS B 1 22  ? 11.12066  21.36855  7.96180   1.000 44.97093 ? 22  CYS B SG  1 
ATOM   2486 N  N   . GLY B 1 23  ? 11.62001  24.25042  5.38597   1.000 45.12986 ? 23  GLY B N   1 
ATOM   2487 C  CA  . GLY B 1 23  ? 12.78584  24.91782  4.83631   1.000 39.17204 ? 23  GLY B CA  1 
ATOM   2488 C  C   . GLY B 1 23  ? 12.59591  25.12381  3.34982   1.000 39.44614 ? 23  GLY B C   1 
ATOM   2489 O  O   . GLY B 1 23  ? 11.55628  25.61737  2.90011   1.000 43.07799 ? 23  GLY B O   1 
ATOM   2490 N  N   . THR B 1 24  ? 13.59640  24.72684  2.57009   1.000 40.35420 ? 24  THR B N   1 
ATOM   2491 C  CA  . THR B 1 24  ? 13.53429  24.83272  1.12067   1.000 43.85989 ? 24  THR B CA  1 
ATOM   2492 C  C   . THR B 1 24  ? 13.00348  23.56893  0.45618   1.000 45.91404 ? 24  THR B C   1 
ATOM   2493 O  O   . THR B 1 24  ? 12.83209  23.55744  -0.76692  1.000 46.06512 ? 24  THR B O   1 
ATOM   2494 C  CB  . THR B 1 24  ? 14.92084  25.16591  0.55364   1.000 45.28693 ? 24  THR B CB  1 
ATOM   2495 O  OG1 . THR B 1 24  ? 15.83013  24.10172  0.85488   1.000 43.65375 ? 24  THR B OG1 1 
ATOM   2496 C  CG2 . THR B 1 24  ? 15.45130  26.45929  1.16344   1.000 43.07779 ? 24  THR B CG2 1 
ATOM   2497 N  N   . THR B 1 25  ? 12.73432  22.51513  1.22473   1.000 43.95254 ? 25  THR B N   1 
ATOM   2498 C  CA  . THR B 1 25  ? 12.29162  21.24076  0.67130   1.000 44.96421 ? 25  THR B CA  1 
ATOM   2499 C  C   . THR B 1 25  ? 10.77127  21.19394  0.60064   1.000 39.00674 ? 25  THR B C   1 
ATOM   2500 O  O   . THR B 1 25  ? 10.08882  21.46248  1.59373   1.000 42.09449 ? 25  THR B O   1 
ATOM   2501 C  CB  . THR B 1 25  ? 12.80653  20.07157  1.51595   1.000 44.76063 ? 25  THR B CB  1 
ATOM   2502 O  OG1 . THR B 1 25  ? 14.22540  19.94711  1.35963   1.000 43.50906 ? 25  THR B OG1 1 
ATOM   2503 C  CG2 . THR B 1 25  ? 12.13824  18.76168  1.09267   1.000 41.53001 ? 25  THR B CG2 1 
ATOM   2504 N  N   . THR B 1 26  ? 10.24769  20.84653  -0.57105  1.000 38.14116 ? 26  THR B N   1 
ATOM   2505 C  CA  . THR B 1 26  ? 8.82563   20.60244  -0.76469  1.000 35.90907 ? 26  THR B CA  1 
ATOM   2506 C  C   . THR B 1 26  ? 8.62869   19.18924  -1.29928  1.000 33.74566 ? 26  THR B C   1 
ATOM   2507 O  O   . THR B 1 26  ? 9.31771   18.77724  -2.23528  1.000 35.66679 ? 26  THR B O   1 
ATOM   2508 C  CB  . THR B 1 26  ? 8.21897   21.62184  -1.72977  1.000 39.06587 ? 26  THR B CB  1 
ATOM   2509 O  OG1 . THR B 1 26  ? 8.13464   22.89653  -1.08617  1.000 49.90589 ? 26  THR B OG1 1 
ATOM   2510 C  CG2 . THR B 1 26  ? 6.83568   21.19230  -2.15297  1.000 40.05938 ? 26  THR B CG2 1 
ATOM   2511 N  N   . LEU B 1 27  ? 7.70326   18.44481  -0.69958  1.000 34.92830 ? 27  LEU B N   1 
ATOM   2512 C  CA  . LEU B 1 27  ? 7.34351   17.12222  -1.20303  1.000 29.56534 ? 27  LEU B CA  1 
ATOM   2513 C  C   . LEU B 1 27  ? 5.86713   16.87303  -0.89112  1.000 28.34194 ? 27  LEU B C   1 
ATOM   2514 O  O   . LEU B 1 27  ? 5.12398   17.79201  -0.52647  1.000 26.61326 ? 27  LEU B O   1 
ATOM   2515 C  CB  . LEU B 1 27  ? 8.28306   16.04818  -0.63253  1.000 25.72505 ? 27  LEU B CB  1 
ATOM   2516 C  CG  . LEU B 1 27  ? 8.65109   16.02946  0.85532   1.000 25.94088 ? 27  LEU B CG  1 
ATOM   2517 C  CD1 . LEU B 1 27  ? 7.43525   15.75231  1.77367   1.000 25.49003 ? 27  LEU B CD1 1 
ATOM   2518 C  CD2 . LEU B 1 27  ? 9.74883   15.00424  1.08308   1.000 29.75903 ? 27  LEU B CD2 1 
ATOM   2519 N  N   . ASN B 1 28  ? 5.43403   15.62691  -1.03984  1.000 20.70218 ? 28  ASN B N   1 
ATOM   2520 C  CA  . ASN B 1 28  ? 4.01994   15.30134  -0.92242  1.000 22.59723 ? 28  ASN B CA  1 
ATOM   2521 C  C   . ASN B 1 28  ? 3.70052   14.69037  0.43632   1.000 21.17564 ? 28  ASN B C   1 
ATOM   2522 O  O   . ASN B 1 28  ? 4.53324   14.02032  1.05226   1.000 23.14814 ? 28  ASN B O   1 
ATOM   2523 C  CB  . ASN B 1 28  ? 3.58942   14.33630  -2.02644  1.000 21.99164 ? 28  ASN B CB  1 
ATOM   2524 C  CG  . ASN B 1 28  ? 3.89447   14.86992  -3.41173  1.000 21.88347 ? 28  ASN B CG  1 
ATOM   2525 O  OD1 . ASN B 1 28  ? 3.18079   15.72196  -3.92209  1.000 23.78852 ? 28  ASN B OD1 1 
ATOM   2526 N  ND2 . ASN B 1 28  ? 4.96208   14.37107  -4.01830  1.000 21.84794 ? 28  ASN B ND2 1 
ATOM   2527 N  N   . GLY B 1 29  ? 2.46746   14.90889  0.88024   1.000 20.71260 ? 29  GLY B N   1 
ATOM   2528 C  CA  . GLY B 1 29  ? 1.98424   14.31645  2.10976   1.000 17.52793 ? 29  GLY B CA  1 
ATOM   2529 C  C   . GLY B 1 29  ? 0.67845   13.58719  1.87623   1.000 20.79873 ? 29  GLY B C   1 
ATOM   2530 O  O   . GLY B 1 29  ? -0.07005  13.88848  0.94642   1.000 20.44612 ? 29  GLY B O   1 
ATOM   2531 N  N   . LEU B 1 30  ? 0.40927   12.61349  2.74093   1.000 20.23259 ? 30  LEU B N   1 
ATOM   2532 C  CA  . LEU B 1 30  ? -0.84451  11.87133  2.71682   1.000 20.39423 ? 30  LEU B CA  1 
ATOM   2533 C  C   . LEU B 1 30  ? -1.68423  12.30842  3.91146   1.000 22.17819 ? 30  LEU B C   1 
ATOM   2534 O  O   . LEU B 1 30  ? -1.30891  12.05871  5.06382   1.000 21.03250 ? 30  LEU B O   1 
ATOM   2535 C  CB  . LEU B 1 30  ? -0.59424  10.36123  2.73982   1.000 18.02615 ? 30  LEU B CB  1 
ATOM   2536 C  CG  . LEU B 1 30  ? -1.85350  9.47745   2.58432   1.000 18.46590 ? 30  LEU B CG  1 
ATOM   2537 C  CD1 . LEU B 1 30  ? -2.45870  9.56048   1.17137   1.000 16.60214 ? 30  LEU B CD1 1 
ATOM   2538 C  CD2 . LEU B 1 30  ? -1.53961  8.03163   2.95027   1.000 16.27590 ? 30  LEU B CD2 1 
ATOM   2539 N  N   . TRP B 1 31  ? -2.82291  12.94742  3.63460   1.000 20.99769 ? 31  TRP B N   1 
ATOM   2540 C  CA  . TRP B 1 31  ? -3.67928  13.52958  4.66639   1.000 21.22584 ? 31  TRP B CA  1 
ATOM   2541 C  C   . TRP B 1 31  ? -4.84581  12.58622  4.93697   1.000 21.02137 ? 31  TRP B C   1 
ATOM   2542 O  O   . TRP B 1 31  ? -5.75927  12.47661  4.11873   1.000 22.05404 ? 31  TRP B O   1 
ATOM   2543 C  CB  . TRP B 1 31  ? -4.17818  14.90108  4.21864   1.000 22.74056 ? 31  TRP B CB  1 
ATOM   2544 C  CG  . TRP B 1 31  ? -5.02546  15.65423  5.19807   1.000 27.09435 ? 31  TRP B CG  1 
ATOM   2545 C  CD1 . TRP B 1 31  ? -5.08378  15.49086  6.56030   1.000 27.50648 ? 31  TRP B CD1 1 
ATOM   2546 C  CD2 . TRP B 1 31  ? -5.93797  16.70490  4.88077   1.000 25.27041 ? 31  TRP B CD2 1 
ATOM   2547 N  NE1 . TRP B 1 31  ? -5.98344  16.38176  7.10281   1.000 24.82698 ? 31  TRP B NE1 1 
ATOM   2548 C  CE2 . TRP B 1 31  ? -6.52007  17.13701  6.09201   1.000 29.82145 ? 31  TRP B CE2 1 
ATOM   2549 C  CE3 . TRP B 1 31  ? -6.32339  17.32372  3.68282   1.000 28.13185 ? 31  TRP B CE3 1 
ATOM   2550 C  CZ2 . TRP B 1 31  ? -7.47067  18.16045  6.13963   1.000 28.94561 ? 31  TRP B CZ2 1 
ATOM   2551 C  CZ3 . TRP B 1 31  ? -7.26546  18.33485  3.73242   1.000 30.46062 ? 31  TRP B CZ3 1 
ATOM   2552 C  CH2 . TRP B 1 31  ? -7.82824  18.74328  4.95490   1.000 29.03916 ? 31  TRP B CH2 1 
ATOM   2553 N  N   . LEU B 1 32  ? -4.80811  11.90900  6.08001   1.000 20.26533 ? 32  LEU B N   1 
ATOM   2554 C  CA  . LEU B 1 32  ? -5.86675  11.01199  6.53263   1.000 25.12218 ? 32  LEU B CA  1 
ATOM   2555 C  C   . LEU B 1 32  ? -6.29020  11.43462  7.93273   1.000 25.47118 ? 32  LEU B C   1 
ATOM   2556 O  O   . LEU B 1 32  ? -5.43742  11.63681  8.80152   1.000 23.97747 ? 32  LEU B O   1 
ATOM   2557 C  CB  . LEU B 1 32  ? -5.39177  9.55359   6.55915   1.000 20.40193 ? 32  LEU B CB  1 
ATOM   2558 C  CG  . LEU B 1 32  ? -4.80530  9.01552   5.25373   1.000 24.22281 ? 32  LEU B CG  1 
ATOM   2559 C  CD1 . LEU B 1 32  ? -4.17020  7.65007   5.46048   1.000 18.98979 ? 32  LEU B CD1 1 
ATOM   2560 C  CD2 . LEU B 1 32  ? -5.89101  8.95609   4.18068   1.000 19.55649 ? 32  LEU B CD2 1 
ATOM   2561 N  N   . ASP B 1 33  ? -7.59850  11.53625  8.15682   1.000 27.05012 ? 33  ASP B N   1 
ATOM   2562 C  CA  . ASP B 1 33  ? -8.14277  12.08206  9.40709   1.000 28.58141 ? 33  ASP B CA  1 
ATOM   2563 C  C   . ASP B 1 33  ? -7.39216  13.38734  9.67965   1.000 25.92766 ? 33  ASP B C   1 
ATOM   2564 O  O   . ASP B 1 33  ? -7.28566  14.23145  8.77924   1.000 26.44139 ? 33  ASP B O   1 
ATOM   2565 C  CB  . ASP B 1 33  ? -8.05925  11.03327  10.51297  1.000 25.97246 ? 33  ASP B CB  1 
ATOM   2566 C  CG  . ASP B 1 33  ? -8.67753  9.70083   10.11316  1.000 29.04110 ? 33  ASP B CG  1 
ATOM   2567 O  OD1 . ASP B 1 33  ? -9.86494  9.67663   9.72912   1.000 30.33299 ? 33  ASP B OD1 1 
ATOM   2568 O  OD2 . ASP B 1 33  ? -7.95896  8.67367   10.17748  1.000 36.48640 ? 33  ASP B OD2 1 
ATOM   2569 N  N   . ASP B 1 34  ? -6.82180  13.58005  10.86581  1.000 27.23820 ? 34  ASP B N   1 
ATOM   2570 C  CA  . ASP B 1 34  ? -6.13321  14.81831  11.20078  1.000 28.06456 ? 34  ASP B CA  1 
ATOM   2571 C  C   . ASP B 1 34  ? -4.62279  14.62887  11.26348  1.000 27.73827 ? 34  ASP B C   1 
ATOM   2572 O  O   . ASP B 1 34  ? -3.93806  15.32183  12.02460  1.000 31.47791 ? 34  ASP B O   1 
ATOM   2573 C  CB  . ASP B 1 34  ? -6.66418  15.38020  12.51774  1.000 28.05259 ? 34  ASP B CB  1 
ATOM   2574 C  CG  . ASP B 1 34  ? -6.38806  14.45974  13.69875  1.000 37.51185 ? 34  ASP B CG  1 
ATOM   2575 O  OD1 . ASP B 1 34  ? -6.11175  13.26120  13.47312  1.000 32.23269 ? 34  ASP B OD1 1 
ATOM   2576 O  OD2 . ASP B 1 34  ? -6.44710  14.93102  14.85589  1.000 42.30745 ? 34  ASP B OD2 1 
ATOM   2577 N  N   . VAL B 1 35  ? -4.08723  13.69056  10.47679  1.000 22.38700 ? 35  VAL B N   1 
ATOM   2578 C  CA  . VAL B 1 35  ? -2.64579  13.46422  10.40798  1.000 22.42059 ? 35  VAL B CA  1 
ATOM   2579 C  C   . VAL B 1 35  ? -2.19953  13.53260  8.95435   1.000 23.78546 ? 35  VAL B C   1 
ATOM   2580 O  O   . VAL B 1 35  ? -2.87445  13.01351  8.05646   1.000 24.65104 ? 35  VAL B O   1 
ATOM   2581 C  CB  . VAL B 1 35  ? -2.23591  12.11409  11.03367  1.000 23.74167 ? 35  VAL B CB  1 
ATOM   2582 C  CG1 . VAL B 1 35  ? -0.72791  11.90237  10.89771  1.000 20.41572 ? 35  VAL B CG1 1 
ATOM   2583 C  CG2 . VAL B 1 35  ? -2.65585  12.05922  12.49615  1.000 24.20955 ? 35  VAL B CG2 1 
ATOM   2584 N  N   . VAL B 1 36  ? -1.06556  14.18150  8.72522   1.000 22.70059 ? 36  VAL B N   1 
ATOM   2585 C  CA  . VAL B 1 36  ? -0.40037  14.19321  7.43082   1.000 20.07223 ? 36  VAL B CA  1 
ATOM   2586 C  C   . VAL B 1 36  ? 0.86361   13.35407  7.55320   1.000 24.51042 ? 36  VAL B C   1 
ATOM   2587 O  O   . VAL B 1 36  ? 1.64894   13.54717  8.48920   1.000 23.89330 ? 36  VAL B O   1 
ATOM   2588 C  CB  . VAL B 1 36  ? -0.08274  15.62862  6.98413   1.000 22.15004 ? 36  VAL B CB  1 
ATOM   2589 C  CG1 . VAL B 1 36  ? 0.72333   15.62369  5.67828   1.000 20.30100 ? 36  VAL B CG1 1 
ATOM   2590 C  CG2 . VAL B 1 36  ? -1.38104  16.41497  6.83634   1.000 21.78973 ? 36  VAL B CG2 1 
ATOM   2591 N  N   . TYR B 1 37  ? 1.05483   12.42414  6.61440   1.000 22.18601 ? 37  TYR B N   1 
ATOM   2592 C  CA  . TYR B 1 37  ? 2.19093   11.50856  6.59825   1.000 20.51159 ? 37  TYR B CA  1 
ATOM   2593 C  C   . TYR B 1 37  ? 3.12841   11.87936  5.45468   1.000 21.88858 ? 37  TYR B C   1 
ATOM   2594 O  O   . TYR B 1 37  ? 2.67023   12.12212  4.33283   1.000 22.00640 ? 37  TYR B O   1 
ATOM   2595 C  CB  . TYR B 1 37  ? 1.72125   10.05774  6.43236   1.000 20.20329 ? 37  TYR B CB  1 
ATOM   2596 C  CG  . TYR B 1 37  ? 0.72201   9.58915   7.46558   1.000 22.52730 ? 37  TYR B CG  1 
ATOM   2597 C  CD1 . TYR B 1 37  ? -0.62260  9.93445   7.36835   1.000 20.26738 ? 37  TYR B CD1 1 
ATOM   2598 C  CD2 . TYR B 1 37  ? 1.11868   8.79431   8.54002   1.000 21.79747 ? 37  TYR B CD2 1 
ATOM   2599 C  CE1 . TYR B 1 37  ? -1.54410  9.50890   8.31405   1.000 21.43296 ? 37  TYR B CE1 1 
ATOM   2600 C  CE2 . TYR B 1 37  ? 0.19864   8.35791   9.49204   1.000 20.77518 ? 37  TYR B CE2 1 
ATOM   2601 C  CZ  . TYR B 1 37  ? -1.12841  8.72338   9.37270   1.000 24.38103 ? 37  TYR B CZ  1 
ATOM   2602 O  OH  . TYR B 1 37  ? -2.05058  8.30104   10.30299  1.000 26.11273 ? 37  TYR B OH  1 
ATOM   2603 N  N   . CYS B 1 38  ? 4.43261   11.90665  5.72461   1.000 22.60644 ? 38  CYS B N   1 
ATOM   2604 C  CA  . CYS B 1 38  ? 5.40951   12.22126  4.68940   1.000 19.14773 ? 38  CYS B CA  1 
ATOM   2605 C  C   . CYS B 1 38  ? 6.75633   11.63468  5.10014   1.000 21.29953 ? 38  CYS B C   1 
ATOM   2606 O  O   . CYS B 1 38  ? 6.93917   11.22126  6.25350   1.000 22.83961 ? 38  CYS B O   1 
ATOM   2607 C  CB  . CYS B 1 38  ? 5.50340   13.73995  4.44988   1.000 23.55719 ? 38  CYS B CB  1 
ATOM   2608 S  SG  . CYS B 1 38  ? 6.31103   14.70292  5.75967   1.000 27.10462 ? 38  CYS B SG  1 
ATOM   2609 N  N   . PRO B 1 39  ? 7.71856   11.55711  4.17767   1.000 22.47161 ? 39  PRO B N   1 
ATOM   2610 C  CA  . PRO B 1 39  ? 9.03216   11.01700  4.55090   1.000 22.64782 ? 39  PRO B CA  1 
ATOM   2611 C  C   . PRO B 1 39  ? 9.72895   11.92730  5.55353   1.000 25.62478 ? 39  PRO B C   1 
ATOM   2612 O  O   . PRO B 1 39  ? 9.64496   13.15426  5.46356   1.000 25.65049 ? 39  PRO B O   1 
ATOM   2613 C  CB  . PRO B 1 39  ? 9.78774   10.95967  3.21657   1.000 21.05312 ? 39  PRO B CB  1 
ATOM   2614 C  CG  . PRO B 1 39  ? 8.72018   10.98524  2.16566   1.000 21.47833 ? 39  PRO B CG  1 
ATOM   2615 C  CD  . PRO B 1 39  ? 7.65339   11.86389  2.73639   1.000 20.15312 ? 39  PRO B CD  1 
ATOM   2616 N  N   . ARG B 1 40  ? 10.41671  11.31411  6.52271   1.000 22.96007 ? 40  ARG B N   1 
ATOM   2617 C  CA  . ARG B 1 40  ? 11.08629  12.10341  7.54893   1.000 26.25881 ? 40  ARG B CA  1 
ATOM   2618 C  C   . ARG B 1 40  ? 12.25972  12.89811  6.98842   1.000 26.44844 ? 40  ARG B C   1 
ATOM   2619 O  O   . ARG B 1 40  ? 12.69335  13.86305  7.62355   1.000 29.23675 ? 40  ARG B O   1 
ATOM   2620 C  CB  . ARG B 1 40  ? 11.56217  11.20761  8.70210   1.000 25.31215 ? 40  ARG B CB  1 
ATOM   2621 C  CG  . ARG B 1 40  ? 12.68799  10.23817  8.35216   1.000 23.29498 ? 40  ARG B CG  1 
ATOM   2622 C  CD  . ARG B 1 40  ? 13.18217  9.45088   9.56482   1.000 24.01394 ? 40  ARG B CD  1 
ATOM   2623 N  NE  . ARG B 1 40  ? 14.22656  8.49665   9.19664   1.000 20.62410 ? 40  ARG B NE  1 
ATOM   2624 C  CZ  . ARG B 1 40  ? 14.87362  7.71768   10.05394  1.000 22.89369 ? 40  ARG B CZ  1 
ATOM   2625 N  NH1 . ARG B 1 40  ? 14.60574  7.74785   11.34899  1.000 25.57123 ? 40  ARG B NH1 1 
ATOM   2626 N  NH2 . ARG B 1 40  ? 15.82206  6.89424   9.60159   1.000 19.10098 ? 40  ARG B NH2 1 
ATOM   2627 N  N   . HIS B 1 41  ? 12.76817  12.53810  5.80883   1.000 26.26733 ? 41  HIS B N   1 
ATOM   2628 C  CA  . HIS B 1 41  ? 13.89577  13.27735  5.25253   1.000 28.00478 ? 41  HIS B CA  1 
ATOM   2629 C  C   . HIS B 1 41  ? 13.50136  14.64634  4.71735   1.000 28.55265 ? 41  HIS B C   1 
ATOM   2630 O  O   . HIS B 1 41  ? 14.36861  15.36555  4.21055   1.000 30.78269 ? 41  HIS B O   1 
ATOM   2631 C  CB  . HIS B 1 41  ? 14.62263  12.45137  4.17081   1.000 29.89687 ? 41  HIS B CB  1 
ATOM   2632 C  CG  . HIS B 1 41  ? 13.86557  12.26430  2.88792   1.000 25.52405 ? 41  HIS B CG  1 
ATOM   2633 N  ND1 . HIS B 1 41  ? 13.54145  13.30951  2.04796   1.000 30.15190 ? 41  HIS B ND1 1 
ATOM   2634 C  CD2 . HIS B 1 41  ? 13.43578  11.13894  2.26590   1.000 23.34927 ? 41  HIS B CD2 1 
ATOM   2635 C  CE1 . HIS B 1 41  ? 12.91188  12.84180  0.98304   1.000 26.99703 ? 41  HIS B CE1 1 
ATOM   2636 N  NE2 . HIS B 1 41  ? 12.83817  11.52652  1.08836   1.000 26.28415 ? 41  HIS B NE2 1 
ATOM   2637 N  N   . VAL B 1 42  ? 12.23099  15.03550  4.83403   1.000 26.55839 ? 42  VAL B N   1 
ATOM   2638 C  CA  . VAL B 1 42  ? 11.83165  16.39964  4.52084   1.000 30.92715 ? 42  VAL B CA  1 
ATOM   2639 C  C   . VAL B 1 42  ? 12.50376  17.40449  5.45031   1.000 36.14415 ? 42  VAL B C   1 
ATOM   2640 O  O   . VAL B 1 42  ? 12.63038  18.57871  5.08654   1.000 37.65271 ? 42  VAL B O   1 
ATOM   2641 C  CB  . VAL B 1 42  ? 10.29385  16.53599  4.59006   1.000 26.69683 ? 42  VAL B CB  1 
ATOM   2642 C  CG1 . VAL B 1 42  ? 9.80092   16.37406  6.03940   1.000 29.15207 ? 42  VAL B CG1 1 
ATOM   2643 C  CG2 . VAL B 1 42  ? 9.82644   17.85992  4.00853   1.000 30.20545 ? 42  VAL B CG2 1 
ATOM   2644 N  N   . ILE B 1 43  ? 12.93275  16.97969  6.65068   1.000 32.74735 ? 43  ILE B N   1 
ATOM   2645 C  CA  . ILE B 1 43  ? 13.54371  17.90442  7.60639   1.000 37.78052 ? 43  ILE B CA  1 
ATOM   2646 C  C   . ILE B 1 43  ? 15.05136  18.04528  7.42231   1.000 39.76186 ? 43  ILE B C   1 
ATOM   2647 O  O   . ILE B 1 43  ? 15.69928  18.71773  8.23445   1.000 44.82410 ? 43  ILE B O   1 
ATOM   2648 C  CB  . ILE B 1 43  ? 13.28067  17.50243  9.07561   1.000 37.26462 ? 43  ILE B CB  1 
ATOM   2649 C  CG1 . ILE B 1 43  ? 14.12773  16.29649  9.47172   1.000 32.99692 ? 43  ILE B CG1 1 
ATOM   2650 C  CG2 . ILE B 1 43  ? 11.79963  17.23937  9.32712   1.000 33.99681 ? 43  ILE B CG2 1 
ATOM   2651 C  CD1 . ILE B 1 43  ? 13.83756  15.79406  10.87837  1.000 34.92610 ? 43  ILE B CD1 1 
ATOM   2652 N  N   . CYS B 1 44  ? 15.62906  17.46909  6.37179   1.000 37.71769 ? 44  CYS B N   1 
ATOM   2653 C  CA  . CYS B 1 44  ? 17.07671  17.44760  6.20795   1.000 36.58794 ? 44  CYS B CA  1 
ATOM   2654 C  C   . CYS B 1 44  ? 17.53716  18.46740  5.17800   1.000 42.90781 ? 44  CYS B C   1 
ATOM   2655 O  O   . CYS B 1 44  ? 16.87014  18.68669  4.16541   1.000 44.78351 ? 44  CYS B O   1 
ATOM   2656 C  CB  . CYS B 1 44  ? 17.55276  16.06468  5.78014   1.000 36.09672 ? 44  CYS B CB  1 
ATOM   2657 S  SG  . CYS B 1 44  ? 17.31311  14.80587  7.02890   1.000 41.82296 ? 44  CYS B SG  1 
ATOM   2658 N  N   . THR B 1 45  ? 18.68629  19.08381  5.44390   1.000 45.33119 ? 45  THR B N   1 
ATOM   2659 C  CA  . THR B 1 45  ? 19.39383  19.84147  4.42645   1.000 49.83909 ? 45  THR B CA  1 
ATOM   2660 C  C   . THR B 1 45  ? 20.22204  18.89748  3.55971   1.000 49.78682 ? 45  THR B C   1 
ATOM   2661 O  O   . THR B 1 45  ? 20.35658  17.70320  3.84408   1.000 50.05244 ? 45  THR B O   1 
ATOM   2662 C  CB  . THR B 1 45  ? 20.31374  20.89164  5.05678   1.000 47.56737 ? 45  THR B CB  1 
ATOM   2663 O  OG1 . THR B 1 45  ? 21.40711  20.23485  5.71269   1.000 49.31445 ? 45  THR B OG1 1 
ATOM   2664 C  CG2 . THR B 1 45  ? 19.55711  21.74321  6.06416   1.000 47.73599 ? 45  THR B CG2 1 
ATOM   2665 N  N   . SER B 1 46  ? 20.80469  19.45754  2.49752   1.000 50.35440 ? 46  SER B N   1 
ATOM   2666 C  CA  . SER B 1 46  ? 21.70271  18.67411  1.65555   1.000 52.53917 ? 46  SER B CA  1 
ATOM   2667 C  C   . SER B 1 46  ? 22.88729  18.14940  2.45566   1.000 50.73000 ? 46  SER B C   1 
ATOM   2668 O  O   . SER B 1 46  ? 23.36143  17.03306  2.21502   1.000 50.52182 ? 46  SER B O   1 
ATOM   2669 C  CB  . SER B 1 46  ? 22.17973  19.51431  0.47412   1.000 50.92006 ? 46  SER B CB  1 
ATOM   2670 O  OG  . SER B 1 46  ? 22.70901  20.74865  0.92352   1.000 59.19348 ? 46  SER B OG  1 
ATOM   2671 N  N   . GLU B 1 47  ? 23.37882  18.93778  3.41470   1.000 48.56988 ? 47  GLU B N   1 
ATOM   2672 C  CA  . GLU B 1 47  ? 24.44504  18.44869  4.27963   1.000 49.07149 ? 47  GLU B CA  1 
ATOM   2673 C  C   . GLU B 1 47  ? 23.92178  17.43984  5.29433   1.000 49.17064 ? 47  GLU B C   1 
ATOM   2674 O  O   . GLU B 1 47  ? 24.62060  16.46975  5.61756   1.000 44.99389 ? 47  GLU B O   1 
ATOM   2675 C  CB  . GLU B 1 47  ? 25.12488  19.61772  4.98934   1.000 51.01031 ? 47  GLU B CB  1 
ATOM   2676 N  N   . ASP B 1 48  ? 22.69829  17.64742  5.79631   1.000 48.65820 ? 48  ASP B N   1 
ATOM   2677 C  CA  . ASP B 1 48  ? 22.11539  16.72026  6.76412   1.000 45.64285 ? 48  ASP B CA  1 
ATOM   2678 C  C   . ASP B 1 48  ? 21.96644  15.32315  6.17965   1.000 42.03060 ? 48  ASP B C   1 
ATOM   2679 O  O   . ASP B 1 48  ? 22.22986  14.32666  6.86416   1.000 44.00775 ? 48  ASP B O   1 
ATOM   2680 C  CB  . ASP B 1 48  ? 20.75495  17.23117  7.23586   1.000 45.84650 ? 48  ASP B CB  1 
ATOM   2681 C  CG  . ASP B 1 48  ? 20.86937  18.32064  8.27275   1.000 50.25212 ? 48  ASP B CG  1 
ATOM   2682 O  OD1 . ASP B 1 48  ? 21.90606  18.36146  8.97377   1.000 48.74279 ? 48  ASP B OD1 1 
ATOM   2683 O  OD2 . ASP B 1 48  ? 19.91711  19.12622  8.39201   1.000 44.52344 ? 48  ASP B OD2 1 
ATOM   2684 N  N   . MET B 1 49  ? 21.54093  15.23066  4.91482   1.000 44.91896 ? 49  MET B N   1 
ATOM   2685 C  CA  . MET B 1 49  ? 21.31607  13.93493  4.27871   1.000 43.40483 ? 49  MET B CA  1 
ATOM   2686 C  C   . MET B 1 49  ? 22.55602  13.04720  4.27532   1.000 42.76843 ? 49  MET B C   1 
ATOM   2687 O  O   . MET B 1 49  ? 22.42610  11.82906  4.10964   1.000 39.77817 ? 49  MET B O   1 
ATOM   2688 C  CB  . MET B 1 49  ? 20.83757  14.12116  2.83703   1.000 45.46146 ? 49  MET B CB  1 
ATOM   2689 C  CG  . MET B 1 49  ? 19.38613  14.55163  2.67998   1.000 43.67240 ? 49  MET B CG  1 
ATOM   2690 S  SD  . MET B 1 49  ? 18.20830  13.46609  3.50973   1.000 47.28705 ? 49  MET B SD  1 
ATOM   2691 C  CE  . MET B 1 49  ? 18.71620  11.84284  2.94961   1.000 40.57250 ? 49  MET B CE  1 
ATOM   2692 N  N   . LEU B 1 50  ? 23.75046  13.62288  4.44249   1.000 38.72768 ? 50  LEU B N   1 
ATOM   2693 C  CA  . LEU B 1 50  ? 24.97141  12.82551  4.36403   1.000 40.73791 ? 50  LEU B CA  1 
ATOM   2694 C  C   . LEU B 1 50  ? 25.07778  11.85265  5.52903   1.000 41.29002 ? 50  LEU B C   1 
ATOM   2695 O  O   . LEU B 1 50  ? 25.53722  10.71733  5.35657   1.000 43.63740 ? 50  LEU B O   1 
ATOM   2696 C  CB  . LEU B 1 50  ? 26.19673  13.73838  4.32154   1.000 43.26577 ? 50  LEU B CB  1 
ATOM   2697 C  CG  . LEU B 1 50  ? 26.33380  14.63348  3.09175   1.000 46.57042 ? 50  LEU B CG  1 
ATOM   2698 C  CD1 . LEU B 1 50  ? 27.61725  15.45364  3.17462   1.000 48.63871 ? 50  LEU B CD1 1 
ATOM   2699 C  CD2 . LEU B 1 50  ? 26.29673  13.80103  1.81824   1.000 43.38047 ? 50  LEU B CD2 1 
ATOM   2700 N  N   . ASN B 1 51  ? 24.66950  12.27949  6.71805   1.000 38.46794 ? 51  ASN B N   1 
ATOM   2701 C  CA  . ASN B 1 51  ? 24.69510  11.43176  7.90056   1.000 43.40597 ? 51  ASN B CA  1 
ATOM   2702 C  C   . ASN B 1 51  ? 23.72028  11.99133  8.92999   1.000 42.51270 ? 51  ASN B C   1 
ATOM   2703 O  O   . ASN B 1 51  ? 24.13759  12.56338  9.94382   1.000 37.63359 ? 51  ASN B O   1 
ATOM   2704 C  CB  . ASN B 1 51  ? 26.11077  11.34300  8.47252   1.000 45.96295 ? 51  ASN B CB  1 
ATOM   2705 C  CG  . ASN B 1 51  ? 26.21201  10.36310  9.62043   1.000 49.66283 ? 51  ASN B CG  1 
ATOM   2706 O  OD1 . ASN B 1 51  ? 25.39375  9.45302   9.74446   1.000 52.07044 ? 51  ASN B OD1 1 
ATOM   2707 N  ND2 . ASN B 1 51  ? 27.21606  10.54520  10.47063  1.000 52.03683 ? 51  ASN B ND2 1 
ATOM   2708 N  N   . PRO B 1 52  ? 22.42004  11.83938  8.70904   1.000 40.99545 ? 52  PRO B N   1 
ATOM   2709 C  CA  . PRO B 1 52  ? 21.43898  12.52960  9.54793   1.000 37.33277 ? 52  PRO B CA  1 
ATOM   2710 C  C   . PRO B 1 52  ? 21.21229  11.85070  10.88980  1.000 36.39234 ? 52  PRO B C   1 
ATOM   2711 O  O   . PRO B 1 52  ? 21.28655  10.62686  11.02879  1.000 34.81756 ? 52  PRO B O   1 
ATOM   2712 C  CB  . PRO B 1 52  ? 20.16824  12.48333  8.69210   1.000 37.66877 ? 52  PRO B CB  1 
ATOM   2713 C  CG  . PRO B 1 52  ? 20.31307  11.21891  7.91999   1.000 33.23349 ? 52  PRO B CG  1 
ATOM   2714 C  CD  . PRO B 1 52  ? 21.78294  11.06391  7.63306   1.000 39.72717 ? 52  PRO B CD  1 
ATOM   2715 N  N   . ASN B 1 53  ? 20.93046  12.68148  11.88629  1.000 37.64314 ? 53  ASN B N   1 
ATOM   2716 C  CA  . ASN B 1 53  ? 20.47580  12.25233  13.20833  1.000 37.87236 ? 53  ASN B CA  1 
ATOM   2717 C  C   . ASN B 1 53  ? 19.04079  12.75282  13.31165  1.000 40.38717 ? 53  ASN B C   1 
ATOM   2718 O  O   . ASN B 1 53  ? 18.79116  13.89404  13.70813  1.000 40.49232 ? 53  ASN B O   1 
ATOM   2719 C  CB  . ASN B 1 53  ? 21.36692  12.81429  14.31954  1.000 42.36442 ? 53  ASN B CB  1 
ATOM   2720 C  CG  . ASN B 1 53  ? 21.03401  12.24662  15.69497  1.000 43.75943 ? 53  ASN B CG  1 
ATOM   2721 O  OD1 . ASN B 1 53  ? 19.88247  11.91706  15.99417  1.000 42.71872 ? 53  ASN B OD1 1 
ATOM   2722 N  ND2 . ASN B 1 53  ? 22.05228  12.13924  16.54519  1.000 43.60891 ? 53  ASN B ND2 1 
ATOM   2723 N  N   . TYR B 1 54  ? 18.09451  11.89235  12.93270  1.000 37.83113 ? 54  TYR B N   1 
ATOM   2724 C  CA  . TYR B 1 54  ? 16.73085  12.36322  12.71895  1.000 36.91451 ? 54  TYR B CA  1 
ATOM   2725 C  C   . TYR B 1 54  ? 16.09253  12.84241  14.01038  1.000 35.36753 ? 54  TYR B C   1 
ATOM   2726 O  O   . TYR B 1 54  ? 15.44910  13.89697  14.02716  1.000 34.26805 ? 54  TYR B O   1 
ATOM   2727 C  CB  . TYR B 1 54  ? 15.88722  11.27204  12.06305  1.000 31.49297 ? 54  TYR B CB  1 
ATOM   2728 C  CG  . TYR B 1 54  ? 16.15981  11.17348  10.58701  1.000 27.69125 ? 54  TYR B CG  1 
ATOM   2729 C  CD1 . TYR B 1 54  ? 15.63229  12.10710  9.70482   1.000 30.73618 ? 54  TYR B CD1 1 
ATOM   2730 C  CD2 . TYR B 1 54  ? 16.97229  10.17084  10.07710  1.000 29.07620 ? 54  TYR B CD2 1 
ATOM   2731 C  CE1 . TYR B 1 54  ? 15.89109  12.03227  8.35330   1.000 29.09550 ? 54  TYR B CE1 1 
ATOM   2732 C  CE2 . TYR B 1 54  ? 17.23322  10.08154  8.72138   1.000 25.73935 ? 54  TYR B CE2 1 
ATOM   2733 C  CZ  . TYR B 1 54  ? 16.69674  11.01731  7.86592   1.000 25.24799 ? 54  TYR B CZ  1 
ATOM   2734 O  OH  . TYR B 1 54  ? 16.95110  10.93566  6.51582   1.000 29.98454 ? 54  TYR B OH  1 
ATOM   2735 N  N   . GLU B 1 55  ? 16.26666  12.09499  15.10274  1.000 36.59273 ? 55  GLU B N   1 
ATOM   2736 C  CA  . GLU B 1 55  ? 15.69379  12.52579  16.37455  1.000 38.13043 ? 55  GLU B CA  1 
ATOM   2737 C  C   . GLU B 1 55  ? 16.25330  13.87757  16.80311  1.000 40.26385 ? 55  GLU B C   1 
ATOM   2738 O  O   . GLU B 1 55  ? 15.51460  14.72188  17.32174  1.000 42.04098 ? 55  GLU B O   1 
ATOM   2739 C  CB  . GLU B 1 55  ? 15.92799  11.46312  17.45359  1.000 40.76233 ? 55  GLU B CB  1 
ATOM   2740 C  CG  . GLU B 1 55  ? 17.38444  11.10692  17.71714  1.000 44.18180 ? 55  GLU B CG  1 
ATOM   2741 C  CD  . GLU B 1 55  ? 17.54809  10.00361  18.75701  1.000 46.91489 ? 55  GLU B CD  1 
ATOM   2742 O  OE1 . GLU B 1 55  ? 16.77140  9.01812   18.72777  1.000 38.54208 ? 55  GLU B OE1 1 
ATOM   2743 O  OE2 . GLU B 1 55  ? 18.45681  10.12684  19.60956  1.000 50.65156 ? 55  GLU B OE2 1 
ATOM   2744 N  N   . ASP B 1 56  ? 17.54882  14.11574  16.56046  1.000 41.42051 ? 56  ASP B N   1 
ATOM   2745 C  CA  . ASP B 1 56  ? 18.15162  15.39581  16.92365  1.000 39.55108 ? 56  ASP B CA  1 
ATOM   2746 C  C   . ASP B 1 56  ? 17.72937  16.50677  15.96729  1.000 41.47526 ? 56  ASP B C   1 
ATOM   2747 O  O   . ASP B 1 56  ? 17.45095  17.63140  16.40023  1.000 43.17517 ? 56  ASP B O   1 
ATOM   2748 C  CB  . ASP B 1 56  ? 19.67438  15.26700  16.96248  1.000 41.78653 ? 56  ASP B CB  1 
ATOM   2749 C  CG  . ASP B 1 56  ? 20.36021  16.57850  17.28926  1.000 44.44977 ? 56  ASP B CG  1 
ATOM   2750 O  OD1 . ASP B 1 56  ? 20.18188  17.07420  18.42081  1.000 38.78755 ? 56  ASP B OD1 1 
ATOM   2751 O  OD2 . ASP B 1 56  ? 21.07507  17.11786  16.41461  1.000 46.66723 ? 56  ASP B OD2 1 
ATOM   2752 N  N   . LEU B 1 57  ? 17.68097  16.21685  14.66321  1.000 43.05755 ? 57  LEU B N   1 
ATOM   2753 C  CA  . LEU B 1 57  ? 17.19261  17.20444  13.70314  1.000 40.70473 ? 57  LEU B CA  1 
ATOM   2754 C  C   . LEU B 1 57  ? 15.75208  17.60293  13.98976  1.000 46.02982 ? 57  LEU B C   1 
ATOM   2755 O  O   . LEU B 1 57  ? 15.35010  18.73492  13.69068  1.000 49.35275 ? 57  LEU B O   1 
ATOM   2756 C  CB  . LEU B 1 57  ? 17.30172  16.66071  12.27419  1.000 42.51773 ? 57  LEU B CB  1 
ATOM   2757 C  CG  . LEU B 1 57  ? 18.57035  16.88972  11.44196  1.000 43.35524 ? 57  LEU B CG  1 
ATOM   2758 C  CD1 . LEU B 1 57  ? 19.83228  16.64776  12.23773  1.000 47.48533 ? 57  LEU B CD1 1 
ATOM   2759 C  CD2 . LEU B 1 57  ? 18.55010  15.98577  10.22155  1.000 40.77493 ? 57  LEU B CD2 1 
ATOM   2760 N  N   . LEU B 1 58  ? 14.95940  16.68635  14.55514  1.000 41.84138 ? 58  LEU B N   1 
ATOM   2761 C  CA  . LEU B 1 58  ? 13.54408  16.95305  14.78391  1.000 45.29087 ? 58  LEU B CA  1 
ATOM   2762 C  C   . LEU B 1 58  ? 13.29181  17.66253  16.11242  1.000 49.39498 ? 58  LEU B C   1 
ATOM   2763 O  O   . LEU B 1 58  ? 12.36251  18.47519  16.20533  1.000 46.68108 ? 58  LEU B O   1 
ATOM   2764 C  CB  . LEU B 1 58  ? 12.75211  15.64667  14.72386  1.000 43.27855 ? 58  LEU B CB  1 
ATOM   2765 C  CG  . LEU B 1 58  ? 11.23051  15.76370  14.72667  1.000 40.31774 ? 58  LEU B CG  1 
ATOM   2766 C  CD1 . LEU B 1 58  ? 10.75339  16.54392  13.51016  1.000 42.92752 ? 58  LEU B CD1 1 
ATOM   2767 C  CD2 . LEU B 1 58  ? 10.58960  14.38902  14.77017  1.000 35.75371 ? 58  LEU B CD2 1 
ATOM   2768 N  N   . ILE B 1 59  ? 14.09349  17.36653  17.14388  1.000 49.51545 ? 59  ILE B N   1 
ATOM   2769 C  CA  . ILE B 1 59  ? 14.02801  18.12788  18.39370  1.000 50.19130 ? 59  ILE B CA  1 
ATOM   2770 C  C   . ILE B 1 59  ? 14.18821  19.61318  18.10715  1.000 50.08775 ? 59  ILE B C   1 
ATOM   2771 O  O   . ILE B 1 59  ? 13.45373  20.45266  18.64192  1.000 55.96170 ? 59  ILE B O   1 
ATOM   2772 C  CB  . ILE B 1 59  ? 15.09971  17.63461  19.38971  1.000 47.81234 ? 59  ILE B CB  1 
ATOM   2773 C  CG1 . ILE B 1 59  ? 14.74498  16.25596  19.95419  1.000 45.14047 ? 59  ILE B CG1 1 
ATOM   2774 C  CG2 . ILE B 1 59  ? 15.27672  18.63055  20.52397  1.000 51.93655 ? 59  ILE B CG2 1 
ATOM   2775 C  CD1 . ILE B 1 59  ? 13.80254  16.29553  21.14381  1.000 44.51040 ? 59  ILE B CD1 1 
ATOM   2776 N  N   . ARG B 1 60  ? 15.13827  19.95726  17.24268  1.000 52.27702 ? 60  ARG B N   1 
ATOM   2777 C  CA  . ARG B 1 60  ? 15.41265  21.33794  16.85348  1.000 54.39200 ? 60  ARG B CA  1 
ATOM   2778 C  C   . ARG B 1 60  ? 14.32616  21.94235  15.96674  1.000 51.93071 ? 60  ARG B C   1 
ATOM   2779 O  O   . ARG B 1 60  ? 14.55450  23.04627  15.45435  1.000 54.39583 ? 60  ARG B O   1 
ATOM   2780 C  CB  . ARG B 1 60  ? 16.76657  21.41518  16.14431  1.000 47.54867 ? 60  ARG B CB  1 
ATOM   2781 N  N   . LYS B 1 61  ? 13.18053  21.29634  15.75472  1.000 53.32232 ? 61  LYS B N   1 
ATOM   2782 C  CA  . LYS B 1 61  ? 12.12505  21.82502  14.90429  1.000 52.62504 ? 61  LYS B CA  1 
ATOM   2783 C  C   . LYS B 1 61  ? 10.84784  22.01431  15.71075  1.000 55.30091 ? 61  LYS B C   1 
ATOM   2784 O  O   . LYS B 1 61  ? 10.63843  21.37303  16.74447  1.000 58.35262 ? 61  LYS B O   1 
ATOM   2785 C  CB  . LYS B 1 61  ? 11.85235  20.90115  13.70809  1.000 50.56865 ? 61  LYS B CB  1 
ATOM   2786 C  CG  . LYS B 1 61  ? 13.00669  20.80039  12.73023  1.000 52.14726 ? 61  LYS B CG  1 
ATOM   2787 C  CD  . LYS B 1 61  ? 12.61214  21.32211  11.36094  1.000 50.38409 ? 61  LYS B CD  1 
ATOM   2788 C  CE  . LYS B 1 61  ? 13.84248  21.64100  10.52202  1.000 53.12012 ? 61  LYS B CE  1 
ATOM   2789 N  NZ  . LYS B 1 61  ? 14.80418  20.49980  10.47306  1.000 56.93334 ? 61  LYS B NZ  1 
ATOM   2790 N  N   . SER B 1 62  ? 9.99407   22.90818  15.22030  1.000 51.35422 ? 62  SER B N   1 
ATOM   2791 C  CA  . SER B 1 62  ? 8.70514   23.19993  15.82468  1.000 50.77337 ? 62  SER B CA  1 
ATOM   2792 C  C   . SER B 1 62  ? 7.60130   22.94547  14.80798  1.000 49.08712 ? 62  SER B C   1 
ATOM   2793 O  O   . SER B 1 62  ? 7.85821   22.67535  13.63296  1.000 52.45095 ? 62  SER B O   1 
ATOM   2794 C  CB  . SER B 1 62  ? 8.63670   24.65089  16.31424  1.000 55.60401 ? 62  SER B CB  1 
ATOM   2795 O  OG  . SER B 1 62  ? 8.32638   25.52909  15.24185  1.000 57.90143 ? 62  SER B OG  1 
ATOM   2796 N  N   . ASN B 1 63  ? 6.35404   23.04985  15.27270  1.000 47.39199 ? 63  ASN B N   1 
ATOM   2797 C  CA  . ASN B 1 63  ? 5.21822   22.84374  14.38181  1.000 45.90553 ? 63  ASN B CA  1 
ATOM   2798 C  C   . ASN B 1 63  ? 5.23796   23.81239  13.21053  1.000 50.97491 ? 63  ASN B C   1 
ATOM   2799 O  O   . ASN B 1 63  ? 4.81888   23.45350  12.10353  1.000 46.51265 ? 63  ASN B O   1 
ATOM   2800 C  CB  . ASN B 1 63  ? 3.90770   22.98448  15.15152  1.000 39.98379 ? 63  ASN B CB  1 
ATOM   2801 C  CG  . ASN B 1 63  ? 3.72384   21.89799  16.18228  1.000 40.59686 ? 63  ASN B CG  1 
ATOM   2802 O  OD1 . ASN B 1 63  ? 4.18921   20.77388  16.00267  1.000 43.46512 ? 63  ASN B OD1 1 
ATOM   2803 N  ND2 . ASN B 1 63  ? 3.04775   22.22587  17.27412  1.000 44.02159 ? 63  ASN B ND2 1 
ATOM   2804 N  N   . HIS B 1 64  ? 5.72308   25.03403  13.42752  1.000 53.33212 ? 64  HIS B N   1 
ATOM   2805 C  CA  . HIS B 1 64  ? 5.70711   26.04989  12.38383  1.000 53.32515 ? 64  HIS B CA  1 
ATOM   2806 C  C   . HIS B 1 64  ? 6.87573   25.92627  11.41213  1.000 50.35542 ? 64  HIS B C   1 
ATOM   2807 O  O   . HIS B 1 64  ? 6.93575   26.68315  10.43596  1.000 46.66850 ? 64  HIS B O   1 
ATOM   2808 C  CB  . HIS B 1 64  ? 5.67908   27.44607  13.01217  1.000 57.02600 ? 64  HIS B CB  1 
ATOM   2809 C  CG  . HIS B 1 64  ? 4.29602   27.99307  13.20718  1.000 57.85552 ? 64  HIS B CG  1 
ATOM   2810 N  ND1 . HIS B 1 64  ? 3.68216   28.05015  14.44108  1.000 61.61306 ? 64  HIS B ND1 1 
ATOM   2811 C  CD2 . HIS B 1 64  ? 3.40428   28.50005  12.32133  1.000 58.82943 ? 64  HIS B CD2 1 
ATOM   2812 C  CE1 . HIS B 1 64  ? 2.47472   28.57217  14.30707  1.000 60.55225 ? 64  HIS B CE1 1 
ATOM   2813 N  NE2 . HIS B 1 64  ? 2.28125   28.85381  13.03096  1.000 56.12236 ? 64  HIS B NE2 1 
ATOM   2814 N  N   . ASN B 1 65  ? 7.79634   24.99301  11.64359  1.000 48.45041 ? 65  ASN B N   1 
ATOM   2815 C  CA  . ASN B 1 65  ? 8.75202   24.64027  10.60346  1.000 45.81756 ? 65  ASN B CA  1 
ATOM   2816 C  C   . ASN B 1 65  ? 8.11927   23.83861  9.47991   1.000 44.21392 ? 65  ASN B C   1 
ATOM   2817 O  O   . ASN B 1 65  ? 8.82268   23.49362  8.52466   1.000 47.09390 ? 65  ASN B O   1 
ATOM   2818 C  CB  . ASN B 1 65  ? 9.91469   23.84667  11.19647  1.000 51.83956 ? 65  ASN B CB  1 
ATOM   2819 C  CG  . ASN B 1 65  ? 10.87454  24.71656  11.96829  1.000 53.35733 ? 65  ASN B CG  1 
ATOM   2820 O  OD1 . ASN B 1 65  ? 10.96039  24.63158  13.19428  1.000 51.41503 ? 65  ASN B OD1 1 
ATOM   2821 N  ND2 . ASN B 1 65  ? 11.61089  25.56018  11.25224  1.000 53.46220 ? 65  ASN B ND2 1 
ATOM   2822 N  N   . PHE B 1 66  ? 6.82562   23.53305  9.56604   1.000 43.49780 ? 66  PHE B N   1 
ATOM   2823 C  CA  . PHE B 1 66  ? 6.14565   22.69011  8.59215   1.000 43.12033 ? 66  PHE B CA  1 
ATOM   2824 C  C   . PHE B 1 66  ? 4.98629   23.45849  7.97711   1.000 40.97698 ? 66  PHE B C   1 
ATOM   2825 O  O   . PHE B 1 66  ? 4.01697   23.78810  8.66991   1.000 42.75251 ? 66  PHE B O   1 
ATOM   2826 C  CB  . PHE B 1 66  ? 5.64255   21.39869  9.23851   1.000 38.77489 ? 66  PHE B CB  1 
ATOM   2827 C  CG  . PHE B 1 66  ? 6.72685   20.56078  9.83621   1.000 38.76447 ? 66  PHE B CG  1 
ATOM   2828 C  CD1 . PHE B 1 66  ? 7.53762   19.78300  9.03066   1.000 33.98762 ? 66  PHE B CD1 1 
ATOM   2829 C  CD2 . PHE B 1 66  ? 6.93230   20.54276  11.20878  1.000 37.33438 ? 66  PHE B CD2 1 
ATOM   2830 C  CE1 . PHE B 1 66  ? 8.54059   19.00546  9.57920   1.000 37.35285 ? 66  PHE B CE1 1 
ATOM   2831 C  CE2 . PHE B 1 66  ? 7.92527   19.76861  11.76433  1.000 40.86969 ? 66  PHE B CE2 1 
ATOM   2832 C  CZ  . PHE B 1 66  ? 8.73593   18.99769  10.94886  1.000 39.63405 ? 66  PHE B CZ  1 
ATOM   2833 N  N   . LEU B 1 67  ? 5.08755   23.73190  6.67936   1.000 40.85336 ? 67  LEU B N   1 
ATOM   2834 C  CA  A LEU B 1 67  ? 4.01704   24.34999  5.90754   0.500 38.36432 ? 67  LEU B CA  1 
ATOM   2835 C  CA  B LEU B 1 67  ? 4.01477   24.34917  5.91513   0.500 38.36688 ? 67  LEU B CA  1 
ATOM   2836 C  C   . LEU B 1 67  ? 3.26074   23.24886  5.17287   1.000 37.56960 ? 67  LEU B C   1 
ATOM   2837 O  O   . LEU B 1 67  ? 3.85153   22.52657  4.36688   1.000 38.41389 ? 67  LEU B O   1 
ATOM   2838 C  CB  A LEU B 1 67  ? 4.56568   25.36704  4.90631   0.500 40.07288 ? 67  LEU B CB  1 
ATOM   2839 C  CB  B LEU B 1 67  ? 4.58023   25.38680  4.94625   0.500 40.07580 ? 67  LEU B CB  1 
ATOM   2840 C  CG  A LEU B 1 67  ? 4.95078   26.77573  5.36328   0.500 41.11134 ? 67  LEU B CG  1 
ATOM   2841 C  CG  B LEU B 1 67  ? 3.65345   26.17928  4.02845   0.500 40.12405 ? 67  LEU B CG  1 
ATOM   2842 C  CD1 A LEU B 1 67  ? 6.13577   26.76372  6.31761   0.500 42.13218 ? 67  LEU B CD1 1 
ATOM   2843 C  CD1 B LEU B 1 67  ? 4.19368   27.58807  3.86053   0.500 43.86806 ? 67  LEU B CD1 1 
ATOM   2844 C  CD2 A LEU B 1 67  ? 5.24523   27.64888  4.14967   0.500 41.57793 ? 67  LEU B CD2 1 
ATOM   2845 C  CD2 B LEU B 1 67  ? 3.54268   25.50575  2.67615   0.500 43.66731 ? 67  LEU B CD2 1 
ATOM   2846 N  N   . VAL B 1 68  ? 1.96889   23.11985  5.45313   1.000 36.82199 ? 68  VAL B N   1 
ATOM   2847 C  CA  . VAL B 1 68  ? 1.14006   22.09361  4.82871   1.000 37.49420 ? 68  VAL B CA  1 
ATOM   2848 C  C   . VAL B 1 68  ? 0.02135   22.77205  4.05205   1.000 37.81278 ? 68  VAL B C   1 
ATOM   2849 O  O   . VAL B 1 68  ? -0.79465  23.49883  4.63155   1.000 42.10072 ? 68  VAL B O   1 
ATOM   2850 C  CB  . VAL B 1 68  ? 0.57518   21.10984  5.86023   1.000 34.82312 ? 68  VAL B CB  1 
ATOM   2851 C  CG1 . VAL B 1 68  ? -0.30917  20.09014  5.16637   1.000 38.56626 ? 68  VAL B CG1 1 
ATOM   2852 C  CG2 . VAL B 1 68  ? 1.71469   20.41635  6.58868   1.000 34.12010 ? 68  VAL B CG2 1 
ATOM   2853 N  N   . GLN B 1 69  ? -0.02129  22.52488  2.74669   1.000 37.45617 ? 69  GLN B N   1 
ATOM   2854 C  CA  . GLN B 1 69  ? -1.02347  23.09624  1.85853   1.000 40.00230 ? 69  GLN B CA  1 
ATOM   2855 C  C   . GLN B 1 69  ? -1.91537  21.98431  1.32931   1.000 38.39244 ? 69  GLN B C   1 
ATOM   2856 O  O   . GLN B 1 69  ? -1.42005  21.02073  0.73457   1.000 31.27013 ? 69  GLN B O   1 
ATOM   2857 C  CB  . GLN B 1 69  ? -0.36448  23.83286  0.69476   1.000 45.51388 ? 69  GLN B CB  1 
ATOM   2858 C  CG  . GLN B 1 69  ? 0.46494   25.02930  1.10561   1.000 52.46046 ? 69  GLN B CG  1 
ATOM   2859 C  CD  . GLN B 1 69  ? -0.33829  26.31250  1.12946   1.000 56.78387 ? 69  GLN B CD  1 
ATOM   2860 O  OE1 . GLN B 1 69  ? -1.43034  26.38696  0.56032   1.000 57.84726 ? 69  GLN B OE1 1 
ATOM   2861 N  NE2 . GLN B 1 69  ? 0.19740   27.33267  1.79082   1.000 57.84574 ? 69  GLN B NE2 1 
ATOM   2862 N  N   . ALA B 1 70  ? -3.22304  22.12571  1.53413   1.000 36.55032 ? 70  ALA B N   1 
ATOM   2863 C  CA  . ALA B 1 70  ? -4.22468  21.26389  0.91511   1.000 34.60356 ? 70  ALA B CA  1 
ATOM   2864 C  C   . ALA B 1 70  ? -4.90058  22.07772  -0.18698  1.000 45.16792 ? 70  ALA B C   1 
ATOM   2865 O  O   . ALA B 1 70  ? -5.84507  22.83148  0.07123   1.000 41.66165 ? 70  ALA B O   1 
ATOM   2866 C  CB  . ALA B 1 70  ? -5.22874  20.75827  1.94639   1.000 29.86479 ? 70  ALA B CB  1 
ATOM   2867 N  N   . GLY B 1 71  ? -4.41596  21.92674  -1.41270  1.000 45.98054 ? 71  GLY B N   1 
ATOM   2868 C  CA  . GLY B 1 71  ? -4.86913  22.80597  -2.47822  1.000 46.64871 ? 71  GLY B CA  1 
ATOM   2869 C  C   . GLY B 1 71  ? -4.43540  24.22709  -2.19049  1.000 48.66584 ? 71  GLY B C   1 
ATOM   2870 O  O   . GLY B 1 71  ? -3.24655  24.50436  -1.99955  1.000 50.98390 ? 71  GLY B O   1 
ATOM   2871 N  N   . ASN B 1 72  ? -5.40369  25.14067  -2.13066  1.000 48.52863 ? 72  ASN B N   1 
ATOM   2872 C  CA  . ASN B 1 72  ? -5.14117  26.54058  -1.82964  1.000 52.84254 ? 72  ASN B CA  1 
ATOM   2873 C  C   . ASN B 1 72  ? -5.37752  26.87783  -0.36546  1.000 54.49541 ? 72  ASN B C   1 
ATOM   2874 O  O   . ASN B 1 72  ? -5.43403  28.05929  -0.01849  1.000 58.32531 ? 72  ASN B O   1 
ATOM   2875 C  CB  . ASN B 1 72  ? -6.00238  27.44638  -2.71652  1.000 57.17004 ? 72  ASN B CB  1 
ATOM   2876 C  CG  . ASN B 1 72  ? -5.69921  27.27406  -4.19675  1.000 58.08644 ? 72  ASN B CG  1 
ATOM   2877 O  OD1 . ASN B 1 72  ? -6.56246  26.86980  -4.97605  1.000 59.36019 ? 72  ASN B OD1 1 
ATOM   2878 N  ND2 . ASN B 1 72  ? -4.46823  27.58989  -4.59180  1.000 63.02213 ? 72  ASN B ND2 1 
ATOM   2879 N  N   . VAL B 1 73  ? -5.52278  25.87408  0.49616   1.000 51.29541 ? 73  VAL B N   1 
ATOM   2880 C  CA  . VAL B 1 73  ? -5.82376  26.07132  1.90808   1.000 47.63713 ? 73  VAL B CA  1 
ATOM   2881 C  C   . VAL B 1 73  ? -4.61476  25.64891  2.72837   1.000 51.69775 ? 73  VAL B C   1 
ATOM   2882 O  O   . VAL B 1 73  ? -4.10077  24.53571  2.56253   1.000 47.49339 ? 73  VAL B O   1 
ATOM   2883 C  CB  . VAL B 1 73  ? -7.07321  25.27951  2.32654   1.000 50.17402 ? 73  VAL B CB  1 
ATOM   2884 C  CG1 . VAL B 1 73  ? -7.37962  25.51550  3.79431   1.000 49.19123 ? 73  VAL B CG1 1 
ATOM   2885 C  CG2 . VAL B 1 73  ? -8.25265  25.66224  1.45036   1.000 46.83866 ? 73  VAL B CG2 1 
ATOM   2886 N  N   . GLN B 1 74  ? -4.15846  26.53606  3.60692   1.000 48.54888 ? 74  GLN B N   1 
ATOM   2887 C  CA  . GLN B 1 74  ? -3.08834  26.19335  4.53059   1.000 48.51467 ? 74  GLN B CA  1 
ATOM   2888 C  C   . GLN B 1 74  ? -3.65736  25.35887  5.67005   1.000 44.29461 ? 74  GLN B C   1 
ATOM   2889 O  O   . GLN B 1 74  ? -4.71992  25.67548  6.21076   1.000 47.23435 ? 74  GLN B O   1 
ATOM   2890 C  CB  . GLN B 1 74  ? -2.41895  27.45328  5.07508   1.000 43.26380 ? 74  GLN B CB  1 
ATOM   2891 N  N   . LEU B 1 75  ? -2.96851  24.27582  6.00815   1.000 44.52060 ? 75  LEU B N   1 
ATOM   2892 C  CA  . LEU B 1 75  ? -3.34221  23.42457  7.12865   1.000 46.28135 ? 75  LEU B CA  1 
ATOM   2893 C  C   . LEU B 1 75  ? -2.42157  23.72713  8.30042   1.000 45.36226 ? 75  LEU B C   1 
ATOM   2894 O  O   . LEU B 1 75  ? -1.19534  23.75841  8.13983   1.000 43.33282 ? 75  LEU B O   1 
ATOM   2895 C  CB  . LEU B 1 75  ? -3.25921  21.94470  6.74770   1.000 42.66233 ? 75  LEU B CB  1 
ATOM   2896 C  CG  . LEU B 1 75  ? -4.55650  21.23822  6.35231   1.000 39.16804 ? 75  LEU B CG  1 
ATOM   2897 C  CD1 . LEU B 1 75  ? -5.37407  22.08394  5.39713   1.000 42.16414 ? 75  LEU B CD1 1 
ATOM   2898 C  CD2 . LEU B 1 75  ? -4.24001  19.88685  5.73784   1.000 34.56032 ? 75  LEU B CD2 1 
ATOM   2899 N  N   . ARG B 1 76  ? -3.01455  23.95019  9.47124   1.000 46.45260 ? 76  ARG B N   1 
ATOM   2900 C  CA  . ARG B 1 76  ? -2.25407  24.33544  10.65255  1.000 44.55840 ? 76  ARG B CA  1 
ATOM   2901 C  C   . ARG B 1 76  ? -1.72165  23.08861  11.34959  1.000 39.47833 ? 76  ARG B C   1 
ATOM   2902 O  O   . ARG B 1 76  ? -2.49840  22.22298  11.76640  1.000 40.19764 ? 76  ARG B O   1 
ATOM   2903 C  CB  . ARG B 1 76  ? -3.13295  25.15398  11.59341  1.000 49.85351 ? 76  ARG B CB  1 
ATOM   2904 C  CG  . ARG B 1 76  ? -2.37515  26.05747  12.55314  1.000 52.67288 ? 76  ARG B CG  1 
ATOM   2905 C  CD  . ARG B 1 76  ? -3.33935  26.80008  13.47203  1.000 51.71337 ? 76  ARG B CD  1 
ATOM   2906 N  NE  . ARG B 1 76  ? -3.90888  25.91845  14.48570  1.000 58.40551 ? 76  ARG B NE  1 
ATOM   2907 C  CZ  . ARG B 1 76  ? -5.05436  26.14151  15.11839  1.000 60.94173 ? 76  ARG B CZ  1 
ATOM   2908 N  NH1 . ARG B 1 76  ? -5.80654  27.19492  14.83840  1.000 60.32752 ? 76  ARG B NH1 1 
ATOM   2909 N  NH2 . ARG B 1 76  ? -5.45850  25.28351  16.05214  1.000 58.30288 ? 76  ARG B NH2 1 
ATOM   2910 N  N   . VAL B 1 77  ? -0.40310  23.00011  11.47456  1.000 35.42655 ? 77  VAL B N   1 
ATOM   2911 C  CA  . VAL B 1 77  ? 0.23743   21.87537  12.14838  1.000 40.88851 ? 77  VAL B CA  1 
ATOM   2912 C  C   . VAL B 1 77  ? 0.27238   22.15723  13.64599  1.000 40.88884 ? 77  VAL B C   1 
ATOM   2913 O  O   . VAL B 1 77  ? 0.90943   23.11803  14.09010  1.000 36.12085 ? 77  VAL B O   1 
ATOM   2914 C  CB  . VAL B 1 77  ? 1.65119   21.63979  11.60237  1.000 33.70150 ? 77  VAL B CB  1 
ATOM   2915 C  CG1 . VAL B 1 77  ? 2.30667   20.46783  12.31470  1.000 34.68594 ? 77  VAL B CG1 1 
ATOM   2916 C  CG2 . VAL B 1 77  ? 1.60753   21.41310  10.10053  1.000 41.38948 ? 77  VAL B CG2 1 
ATOM   2917 N  N   . ILE B 1 78  ? -0.40921  21.31457  14.42785  1.000 37.01304 ? 78  ILE B N   1 
ATOM   2918 C  CA  . ILE B 1 78  ? -0.48008  21.48577  15.87536  1.000 36.07329 ? 78  ILE B CA  1 
ATOM   2919 C  C   . ILE B 1 78  ? 0.40877   20.50665  16.62275  1.000 39.90079 ? 78  ILE B C   1 
ATOM   2920 O  O   . ILE B 1 78  ? 0.50311   20.58889  17.85391  1.000 39.94017 ? 78  ILE B O   1 
ATOM   2921 C  CB  . ILE B 1 78  ? -1.93079  21.36446  16.38654  1.000 36.01154 ? 78  ILE B CB  1 
ATOM   2922 C  CG1 . ILE B 1 78  ? -2.50768  19.98457  16.06453  1.000 35.90924 ? 78  ILE B CG1 1 
ATOM   2923 C  CG2 . ILE B 1 78  ? -2.80329  22.46254  15.79828  1.000 41.51229 ? 78  ILE B CG2 1 
ATOM   2924 C  CD1 . ILE B 1 78  ? -3.95416  19.81244  16.49829  1.000 35.71855 ? 78  ILE B CD1 1 
ATOM   2925 N  N   . GLY B 1 79  ? 1.05662   19.57736  15.92226  1.000 36.79105 ? 79  GLY B N   1 
ATOM   2926 C  CA  . GLY B 1 79  ? 1.93315   18.61017  16.55474  1.000 35.13123 ? 79  GLY B CA  1 
ATOM   2927 C  C   . GLY B 1 79  ? 2.66282   17.77339  15.52613  1.000 34.89035 ? 79  GLY B C   1 
ATOM   2928 O  O   . GLY B 1 79  ? 2.18222   17.62267  14.39909  1.000 39.20506 ? 79  GLY B O   1 
ATOM   2929 N  N   . HIS B 1 80  ? 3.82447   17.23548  15.87952  1.000 34.87951 ? 80  HIS B N   1 
ATOM   2930 C  CA  . HIS B 1 80  ? 4.57230   16.40659  14.94977  1.000 35.56002 ? 80  HIS B CA  1 
ATOM   2931 C  C   . HIS B 1 80  ? 5.20107   15.24483  15.69508  1.000 37.11966 ? 80  HIS B C   1 
ATOM   2932 O  O   . HIS B 1 80  ? 5.56698   15.35292  16.86782  1.000 32.75930 ? 80  HIS B O   1 
ATOM   2933 C  CB  . HIS B 1 80  ? 5.64889   17.19357  14.18553  1.000 37.00566 ? 80  HIS B CB  1 
ATOM   2934 C  CG  . HIS B 1 80  ? 6.63162   17.90163  15.06135  1.000 42.08563 ? 80  HIS B CG  1 
ATOM   2935 N  ND1 . HIS B 1 80  ? 6.26235   18.88444  15.95513  1.000 48.18542 ? 80  HIS B ND1 1 
ATOM   2936 C  CD2 . HIS B 1 80  ? 7.97683   17.78895  15.16050  1.000 44.28835 ? 80  HIS B CD2 1 
ATOM   2937 C  CE1 . HIS B 1 80  ? 7.33660   19.33619  16.57799  1.000 47.18065 ? 80  HIS B CE1 1 
ATOM   2938 N  NE2 . HIS B 1 80  ? 8.39020   18.68941  16.11247  1.000 50.03703 ? 80  HIS B NE2 1 
ATOM   2939 N  N   . SER B 1 81  ? 5.32407   14.13046  14.98275  1.000 33.61832 ? 81  SER B N   1 
ATOM   2940 C  CA  . SER B 1 81  ? 5.79023   12.87760  15.54677  1.000 30.11351 ? 81  SER B CA  1 
ATOM   2941 C  C   . SER B 1 81  ? 6.47825   12.08116  14.45086  1.000 29.84244 ? 81  SER B C   1 
ATOM   2942 O  O   . SER B 1 81  ? 6.18664   12.23910  13.26200  1.000 27.61435 ? 81  SER B O   1 
ATOM   2943 C  CB  . SER B 1 81  ? 4.62662   12.07042  16.13035  1.000 29.62061 ? 81  SER B CB  1 
ATOM   2944 O  OG  . SER B 1 81  ? 5.09965   11.14002  17.07305  1.000 40.14953 ? 81  SER B OG  1 
ATOM   2945 N  N   . MET B 1 82  ? 7.37688   11.20120  14.86504  1.000 27.20016 ? 82  MET B N   1 
ATOM   2946 C  CA  . MET B 1 82  ? 8.11058   10.34304  13.95245  1.000 27.95966 ? 82  MET B CA  1 
ATOM   2947 C  C   . MET B 1 82  ? 7.80023   8.88963   14.28798  1.000 29.11463 ? 82  MET B C   1 
ATOM   2948 O  O   . MET B 1 82  ? 7.84832   8.49002   15.45756  1.000 27.62891 ? 82  MET B O   1 
ATOM   2949 C  CB  . MET B 1 82  ? 9.61497   10.62165  14.04860  1.000 28.40165 ? 82  MET B CB  1 
ATOM   2950 C  CG  . MET B 1 82  ? 10.44249  10.06344  12.90399  1.000 28.74167 ? 82  MET B CG  1 
ATOM   2951 S  SD  . MET B 1 82  ? 12.15630  10.67144  12.92626  1.000 29.70347 ? 82  MET B SD  1 
ATOM   2952 C  CE  . MET B 1 82  ? 12.60741  10.38700  14.64018  1.000 34.93341 ? 82  MET B CE  1 
ATOM   2953 N  N   . GLN B 1 83  ? 7.45462   8.11343   13.26521  1.000 26.59642 ? 83  GLN B N   1 
ATOM   2954 C  CA  . GLN B 1 83  ? 7.28174   6.66785   13.37663  1.000 24.18345 ? 83  GLN B CA  1 
ATOM   2955 C  C   . GLN B 1 83  ? 8.18450   6.04266   12.32892  1.000 23.58078 ? 83  GLN B C   1 
ATOM   2956 O  O   . GLN B 1 83  ? 7.88914   6.12009   11.13082  1.000 22.36965 ? 83  GLN B O   1 
ATOM   2957 C  CB  . GLN B 1 83  ? 5.82829   6.23520   13.16286  1.000 27.99202 ? 83  GLN B CB  1 
ATOM   2958 C  CG  . GLN B 1 83  ? 5.67596   4.71370   13.07752  1.000 25.80608 ? 83  GLN B CG  1 
ATOM   2959 C  CD  . GLN B 1 83  ? 4.23509   4.24888   13.12908  1.000 32.42569 ? 83  GLN B CD  1 
ATOM   2960 O  OE1 . GLN B 1 83  ? 3.32594   4.93061   12.65320  1.000 34.21387 ? 83  GLN B OE1 1 
ATOM   2961 N  NE2 . GLN B 1 83  ? 4.01902   3.07597   13.71190  1.000 32.29914 ? 83  GLN B NE2 1 
ATOM   2962 N  N   . ASN B 1 84  ? 9.28041   5.43386   12.77733  1.000 19.25616 ? 84  ASN B N   1 
ATOM   2963 C  CA  . ASN B 1 84  ? 10.29645  4.86863   11.88979  1.000 20.52380 ? 84  ASN B CA  1 
ATOM   2964 C  C   . ASN B 1 84  ? 10.70085  5.96516   10.90139  1.000 22.00942 ? 84  ASN B C   1 
ATOM   2965 O  O   . ASN B 1 84  ? 10.97483  7.09370   11.33647  1.000 21.56465 ? 84  ASN B O   1 
ATOM   2966 C  CB  . ASN B 1 84  ? 9.74882   3.58301   11.28421  1.000 21.93420 ? 84  ASN B CB  1 
ATOM   2967 C  CG  . ASN B 1 84  ? 9.44440   2.53461   12.33482  1.000 24.43789 ? 84  ASN B CG  1 
ATOM   2968 O  OD1 . ASN B 1 84  ? 10.27468  2.25514   13.20980  1.000 25.71367 ? 84  ASN B OD1 1 
ATOM   2969 N  ND2 . ASN B 1 84  ? 8.24381   1.95342   12.26943  1.000 20.93607 ? 84  ASN B ND2 1 
ATOM   2970 N  N   . CYS B 1 85  ? 10.72028  5.70333   9.59161   1.000 18.63824 ? 85  CYS B N   1 
ATOM   2971 C  CA  . CYS B 1 85  ? 11.18852  6.68296   8.61851   1.000 19.96007 ? 85  CYS B CA  1 
ATOM   2972 C  C   . CYS B 1 85  ? 10.09355  7.60943   8.11432   1.000 20.38262 ? 85  CYS B C   1 
ATOM   2973 O  O   . CYS B 1 85  ? 10.32032  8.33658   7.13931   1.000 23.01210 ? 85  CYS B O   1 
ATOM   2974 C  CB  . CYS B 1 85  ? 11.83243  5.98618   7.42504   1.000 17.94073 ? 85  CYS B CB  1 
ATOM   2975 S  SG  . CYS B 1 85  ? 13.22649  4.96077   7.87456   1.000 19.96155 ? 85  CYS B SG  1 
ATOM   2976 N  N   . VAL B 1 86  ? 8.92677   7.61014   8.75000   1.000 17.24791 ? 86  VAL B N   1 
ATOM   2977 C  CA  . VAL B 1 86  ? 7.79961   8.43137   8.33511   1.000 18.17210 ? 86  VAL B CA  1 
ATOM   2978 C  C   . VAL B 1 86  ? 7.51909   9.50105   9.38674   1.000 25.67941 ? 86  VAL B C   1 
ATOM   2979 O  O   . VAL B 1 86  ? 7.52791   9.22947   10.59552  1.000 22.32849 ? 86  VAL B O   1 
ATOM   2980 C  CB  . VAL B 1 86  ? 6.56185   7.54990   8.06870   1.000 19.54272 ? 86  VAL B CB  1 
ATOM   2981 C  CG1 . VAL B 1 86  ? 5.29712   8.25375   8.46955   1.000 21.07377 ? 86  VAL B CG1 1 
ATOM   2982 C  CG2 . VAL B 1 86  ? 6.52181   7.17054   6.57429   1.000 21.41067 ? 86  VAL B CG2 1 
ATOM   2983 N  N   . LEU B 1 87  ? 7.27704   10.72278  8.91599   1.000 23.31769 ? 87  LEU B N   1 
ATOM   2984 C  CA  . LEU B 1 87  ? 6.89643   11.84122  9.76606   1.000 22.62105 ? 87  LEU B CA  1 
ATOM   2985 C  C   . LEU B 1 87  ? 5.37581   11.97822  9.80927   1.000 21.54607 ? 87  LEU B C   1 
ATOM   2986 O  O   . LEU B 1 87  ? 4.69838   11.87835  8.78294   1.000 23.45762 ? 87  LEU B O   1 
ATOM   2987 C  CB  . LEU B 1 87  ? 7.53570   13.12588  9.23617   1.000 23.09519 ? 87  LEU B CB  1 
ATOM   2988 C  CG  . LEU B 1 87  ? 7.39281   14.45071  9.97785   1.000 29.31135 ? 87  LEU B CG  1 
ATOM   2989 C  CD1 . LEU B 1 87  ? 7.89174   14.34989  11.39954  1.000 30.75465 ? 87  LEU B CD1 1 
ATOM   2990 C  CD2 . LEU B 1 87  ? 8.19084   15.51425  9.21862   1.000 29.55713 ? 87  LEU B CD2 1 
ATOM   2991 N  N   . LYS B 1 88  ? 4.84360   12.19435  11.00632  1.000 23.90890 ? 88  LYS B N   1 
ATOM   2992 C  CA  . LYS B 1 88  ? 3.41110   12.35757  11.22905  1.000 22.87642 ? 88  LYS B CA  1 
ATOM   2993 C  C   . LYS B 1 88  ? 3.16858   13.76006  11.76859  1.000 28.05866 ? 88  LYS B C   1 
ATOM   2994 O  O   . LYS B 1 88  ? 3.58108   14.07936  12.89014  1.000 29.66431 ? 88  LYS B O   1 
ATOM   2995 C  CB  . LYS B 1 88  ? 2.87407   11.30090  12.19103  1.000 22.02282 ? 88  LYS B CB  1 
ATOM   2996 C  CG  . LYS B 1 88  ? 3.00398   9.87021   11.67457  1.000 26.14931 ? 88  LYS B CG  1 
ATOM   2997 C  CD  . LYS B 1 88  ? 2.16010   8.89385   12.48221  1.000 28.54983 ? 88  LYS B CD  1 
ATOM   2998 C  CE  . LYS B 1 88  ? 2.71562   8.66869   13.87503  1.000 36.19899 ? 88  LYS B CE  1 
ATOM   2999 N  NZ  . LYS B 1 88  ? 1.91725   7.62037   14.60050  1.000 40.77172 ? 88  LYS B NZ  1 
ATOM   3000 N  N   . LEU B 1 89  ? 2.49932   14.58995  10.97536  1.000 25.17547 ? 89  LEU B N   1 
ATOM   3001 C  CA  . LEU B 1 89  ? 2.15504   15.95268  11.35925  1.000 27.34769 ? 89  LEU B CA  1 
ATOM   3002 C  C   . LEU B 1 89  ? 0.67954   15.97872  11.74042  1.000 28.42117 ? 89  LEU B C   1 
ATOM   3003 O  O   . LEU B 1 89  ? -0.19012  15.75203  10.89204  1.000 28.44559 ? 89  LEU B O   1 
ATOM   3004 C  CB  . LEU B 1 89  ? 2.44205   16.92524  10.21674  1.000 29.09508 ? 89  LEU B CB  1 
ATOM   3005 C  CG  . LEU B 1 89  ? 3.83622   16.89429  9.57742   1.000 30.12487 ? 89  LEU B CG  1 
ATOM   3006 C  CD1 . LEU B 1 89  ? 3.90872   17.83103  8.38157   1.000 29.13728 ? 89  LEU B CD1 1 
ATOM   3007 C  CD2 . LEU B 1 89  ? 4.90045   17.25570  10.59817  1.000 31.75565 ? 89  LEU B CD2 1 
ATOM   3008 N  N   . LYS B 1 90  ? 0.39567   16.23227  13.01630  1.000 29.94932 ? 90  LYS B N   1 
ATOM   3009 C  CA  . LYS B 1 90  ? -0.97767  16.47939  13.43467  1.000 30.97741 ? 90  LYS B CA  1 
ATOM   3010 C  C   . LYS B 1 90  ? -1.42774  17.82566  12.89318  1.000 31.82805 ? 90  LYS B C   1 
ATOM   3011 O  O   . LYS B 1 90  ? -0.69275  18.81286  12.98271  1.000 34.24463 ? 90  LYS B O   1 
ATOM   3012 C  CB  . LYS B 1 90  ? -1.10167  16.46910  14.95960  1.000 34.65691 ? 90  LYS B CB  1 
ATOM   3013 C  CG  . LYS B 1 90  ? -1.51290  15.14189  15.56443  1.000 40.17300 ? 90  LYS B CG  1 
ATOM   3014 C  CD  . LYS B 1 90  ? -2.98911  14.83970  15.37225  1.000 36.01172 ? 90  LYS B CD  1 
ATOM   3015 C  CE  . LYS B 1 90  ? -3.29633  13.40484  15.80149  1.000 40.09000 ? 90  LYS B CE  1 
ATOM   3016 N  NZ  . LYS B 1 90  ? -4.75677  13.07163  15.82948  1.000 37.12848 ? 90  LYS B NZ  1 
ATOM   3017 N  N   . VAL B 1 91  ? -2.63034  17.86772  12.32236  1.000 33.54097 ? 91  VAL B N   1 
ATOM   3018 C  CA  . VAL B 1 91  ? -3.19275  19.11466  11.82732  1.000 36.34117 ? 91  VAL B CA  1 
ATOM   3019 C  C   . VAL B 1 91  ? -4.50247  19.37498  12.55941  1.000 34.01230 ? 91  VAL B C   1 
ATOM   3020 O  O   . VAL B 1 91  ? -5.07153  18.48871  13.19635  1.000 35.86935 ? 91  VAL B O   1 
ATOM   3021 C  CB  . VAL B 1 91  ? -3.39613  19.10516  10.29633  1.000 32.91101 ? 91  VAL B CB  1 
ATOM   3022 C  CG1 . VAL B 1 91  ? -2.05708  19.10358  9.59466   1.000 34.24876 ? 91  VAL B CG1 1 
ATOM   3023 C  CG2 . VAL B 1 91  ? -4.23485  17.91073  9.86200   1.000 29.85624 ? 91  VAL B CG2 1 
ATOM   3024 N  N   . ASP B 1 92  ? -4.97575  20.61453  12.46941  1.000 39.49471 ? 92  ASP B N   1 
ATOM   3025 C  CA  . ASP B 1 92  ? -6.16590  21.02604  13.20739  1.000 39.30374 ? 92  ASP B CA  1 
ATOM   3026 C  C   . ASP B 1 92  ? -7.46984  20.63766  12.52353  1.000 43.41431 ? 92  ASP B C   1 
ATOM   3027 O  O   . ASP B 1 92  ? -8.54105  20.89698  13.08375  1.000 45.55918 ? 92  ASP B O   1 
ATOM   3028 C  CB  . ASP B 1 92  ? -6.14709  22.54293  13.44642  1.000 46.82645 ? 92  ASP B CB  1 
ATOM   3029 C  CG  . ASP B 1 92  ? -6.17627  23.36077  12.14842  1.000 51.83495 ? 92  ASP B CG  1 
ATOM   3030 O  OD1 . ASP B 1 92  ? -6.20382  22.78219  11.04124  1.000 49.87050 ? 92  ASP B OD1 1 
ATOM   3031 O  OD2 . ASP B 1 92  ? -6.16953  24.60635  12.24072  1.000 56.23391 ? 92  ASP B OD2 1 
ATOM   3032 N  N   . THR B 1 93  ? -7.41668  20.03201  11.33982  1.000 41.08924 ? 93  THR B N   1 
ATOM   3033 C  CA  . THR B 1 93  ? -8.61586  19.71750  10.57342  1.000 37.95756 ? 93  THR B CA  1 
ATOM   3034 C  C   . THR B 1 93  ? -8.56328  18.27407  10.09700  1.000 33.54544 ? 93  THR B C   1 
ATOM   3035 O  O   . THR B 1 93  ? -7.55365  17.84207  9.53447   1.000 30.43780 ? 93  THR B O   1 
ATOM   3036 C  CB  . THR B 1 93  ? -8.76186  20.64374  9.35993   1.000 40.02180 ? 93  THR B CB  1 
ATOM   3037 O  OG1 . THR B 1 93  ? -8.59087  22.00963  9.76253   1.000 43.66260 ? 93  THR B OG1 1 
ATOM   3038 C  CG2 . THR B 1 93  ? -10.13784 20.46391  8.72459   1.000 39.16886 ? 93  THR B CG2 1 
ATOM   3039 N  N   . ALA B 1 94  ? -9.64972  17.53742  10.31194  1.000 33.23294 ? 94  ALA B N   1 
ATOM   3040 C  CA  . ALA B 1 94  ? -9.78467  16.22472  9.69888   1.000 31.05014 ? 94  ALA B CA  1 
ATOM   3041 C  C   . ALA B 1 94  ? -10.05311 16.36705  8.19972   1.000 32.02196 ? 94  ALA B C   1 
ATOM   3042 O  O   . ALA B 1 94  ? -10.75967 17.28005  7.76061   1.000 30.29124 ? 94  ALA B O   1 
ATOM   3043 C  CB  . ALA B 1 94  ? -10.90552 15.43752  10.37909  1.000 24.56735 ? 94  ALA B CB  1 
ATOM   3044 N  N   . ASN B 1 95  ? -9.46132  15.47852  7.41159   1.000 32.99269 ? 95  ASN B N   1 
ATOM   3045 C  CA  . ASN B 1 95  ? -9.68990  15.46988  5.96682   1.000 27.17807 ? 95  ASN B CA  1 
ATOM   3046 C  C   . ASN B 1 95  ? -11.09722 14.96210  5.69772   1.000 24.93922 ? 95  ASN B C   1 
ATOM   3047 O  O   . ASN B 1 95  ? -11.37204 13.78168  5.94894   1.000 25.68734 ? 95  ASN B O   1 
ATOM   3048 C  CB  . ASN B 1 95  ? -8.64965  14.59583  5.25275   1.000 24.84999 ? 95  ASN B CB  1 
ATOM   3049 C  CG  . ASN B 1 95  ? -8.78207  14.64085  3.72374   1.000 29.40525 ? 95  ASN B CG  1 
ATOM   3050 O  OD1 . ASN B 1 95  ? -9.60980  15.37493  3.17304   1.000 24.10362 ? 95  ASN B OD1 1 
ATOM   3051 N  ND2 . ASN B 1 95  ? -7.95395  13.85715  3.03734   1.000 24.96218 ? 95  ASN B ND2 1 
ATOM   3052 N  N   . PRO B 1 96  ? -12.01638 15.79418  5.20262   1.000 23.52710 ? 96  PRO B N   1 
ATOM   3053 C  CA  . PRO B 1 96  ? -13.38528 15.31227  5.00363   1.000 21.22693 ? 96  PRO B CA  1 
ATOM   3054 C  C   . PRO B 1 96  ? -13.49526 14.30159  3.88157   1.000 26.56312 ? 96  PRO B C   1 
ATOM   3055 O  O   . PRO B 1 96  ? -14.48763 13.56792  3.82478   1.000 27.50924 ? 96  PRO B O   1 
ATOM   3056 C  CB  . PRO B 1 96  ? -14.16621 16.59496  4.69354   1.000 24.56609 ? 96  PRO B CB  1 
ATOM   3057 C  CG  . PRO B 1 96  ? -13.17033 17.48941  4.08059   1.000 23.19935 ? 96  PRO B CG  1 
ATOM   3058 C  CD  . PRO B 1 96  ? -11.84890 17.18457  4.74419   1.000 23.89088 ? 96  PRO B CD  1 
ATOM   3059 N  N   . LYS B 1 97  ? -12.50689 14.23078  2.99850   1.000 24.50648 ? 97  LYS B N   1 
ATOM   3060 C  CA  . LYS B 1 97  ? -12.46151 13.22621  1.94891   1.000 28.44062 ? 97  LYS B CA  1 
ATOM   3061 C  C   . LYS B 1 97  ? -11.74127 11.95170  2.37947   1.000 29.08039 ? 97  LYS B C   1 
ATOM   3062 O  O   . LYS B 1 97  ? -11.42898 11.12083  1.52164   1.000 24.04667 ? 97  LYS B O   1 
ATOM   3063 C  CB  . LYS B 1 97  ? -11.77352 13.79442  0.70290   1.000 26.08964 ? 97  LYS B CB  1 
ATOM   3064 C  CG  . LYS B 1 97  ? -12.40849 15.04845  0.12172   1.000 29.24416 ? 97  LYS B CG  1 
ATOM   3065 C  CD  . LYS B 1 97  ? -11.41192 15.73510  -0.79271  1.000 34.37560 ? 97  LYS B CD  1 
ATOM   3066 C  CE  . LYS B 1 97  ? -11.92947 17.06242  -1.31270  1.000 41.80378 ? 97  LYS B CE  1 
ATOM   3067 N  NZ  . LYS B 1 97  ? -12.89542 16.86433  -2.42224  1.000 44.73267 ? 97  LYS B NZ  1 
ATOM   3068 N  N   . THR B 1 98  ? -11.44692 11.78583  3.66837   1.000 28.06584 ? 98  THR B N   1 
ATOM   3069 C  CA  . THR B 1 98  ? -10.75250 10.57848  4.11733   1.000 25.63136 ? 98  THR B CA  1 
ATOM   3070 C  C   . THR B 1 98  ? -11.57233 9.34678   3.74565   1.000 26.25534 ? 98  THR B C   1 
ATOM   3071 O  O   . THR B 1 98  ? -12.73343 9.23756   4.16798   1.000 25.74803 ? 98  THR B O   1 
ATOM   3072 C  CB  . THR B 1 98  ? -10.50978 10.59875  5.62786   1.000 27.82945 ? 98  THR B CB  1 
ATOM   3073 O  OG1 . THR B 1 98  ? -9.70659  11.73303  5.97722   1.000 23.22991 ? 98  THR B OG1 1 
ATOM   3074 C  CG2 . THR B 1 98  ? -9.78271  9.32607   6.06769   1.000 23.11057 ? 98  THR B CG2 1 
ATOM   3075 N  N   . PRO B 1 99  ? -11.03182 8.41909   2.96253   1.000 22.68889 ? 99  PRO B N   1 
ATOM   3076 C  CA  . PRO B 1 99  ? -11.76264 7.19774   2.62817   1.000 21.63475 ? 99  PRO B CA  1 
ATOM   3077 C  C   . PRO B 1 99  ? -11.60597 6.14450   3.71861   1.000 20.58718 ? 99  PRO B C   1 
ATOM   3078 O  O   . PRO B 1 99  ? -10.79840 6.27785   4.63898   1.000 22.63010 ? 99  PRO B O   1 
ATOM   3079 C  CB  . PRO B 1 99  ? -11.07228 6.74335   1.34020   1.000 21.73533 ? 99  PRO B CB  1 
ATOM   3080 C  CG  . PRO B 1 99  ? -9.63250  7.13196   1.57426   1.000 20.94296 ? 99  PRO B CG  1 
ATOM   3081 C  CD  . PRO B 1 99  ? -9.68994  8.44228   2.34454   1.000 23.59656 ? 99  PRO B CD  1 
ATOM   3082 N  N   . LYS B 1 100 ? -12.40399 5.08534   3.59755   1.000 20.08636 ? 100 LYS B N   1 
ATOM   3083 C  CA  . LYS B 1 100 ? -12.09592 3.86324   4.32708   1.000 21.87487 ? 100 LYS B CA  1 
ATOM   3084 C  C   . LYS B 1 100 ? -10.71188 3.39278   3.90541   1.000 19.39255 ? 100 LYS B C   1 
ATOM   3085 O  O   . LYS B 1 100 ? -10.42077 3.30342   2.70601   1.000 20.19107 ? 100 LYS B O   1 
ATOM   3086 C  CB  . LYS B 1 100 ? -13.13087 2.77354   4.03736   1.000 22.15066 ? 100 LYS B CB  1 
ATOM   3087 C  CG  . LYS B 1 100 ? -14.52848 3.04878   4.58082   1.000 32.32174 ? 100 LYS B CG  1 
ATOM   3088 C  CD  . LYS B 1 100 ? -15.46846 1.89141   4.23606   1.000 42.73860 ? 100 LYS B CD  1 
ATOM   3089 C  CE  . LYS B 1 100 ? -16.86909 2.09230   4.80342   1.000 50.32563 ? 100 LYS B CE  1 
ATOM   3090 N  NZ  . LYS B 1 100 ? -17.73578 0.90101   4.55767   1.000 53.70404 ? 100 LYS B NZ  1 
ATOM   3091 N  N   . TYR B 1 101 ? -9.85637  3.09751   4.88169   1.000 20.44620 ? 101 TYR B N   1 
ATOM   3092 C  CA  . TYR B 1 101 ? -8.47590  2.77987   4.53625   1.000 20.75764 ? 101 TYR B CA  1 
ATOM   3093 C  C   . TYR B 1 101 ? -7.83304  1.94600   5.62732   1.000 23.54375 ? 101 TYR B C   1 
ATOM   3094 O  O   . TYR B 1 101 ? -8.28537  1.91667   6.77767   1.000 25.48617 ? 101 TYR B O   1 
ATOM   3095 C  CB  . TYR B 1 101 ? -7.63334  4.04547   4.31160   1.000 20.20491 ? 101 TYR B CB  1 
ATOM   3096 C  CG  . TYR B 1 101 ? -7.21540  4.72275   5.60753   1.000 22.28247 ? 101 TYR B CG  1 
ATOM   3097 C  CD1 . TYR B 1 101 ? -8.02383  5.68467   6.19354   1.000 21.08631 ? 101 TYR B CD1 1 
ATOM   3098 C  CD2 . TYR B 1 101 ? -6.02005  4.39659   6.24496   1.000 20.31570 ? 101 TYR B CD2 1 
ATOM   3099 C  CE1 . TYR B 1 101 ? -7.66317  6.30178   7.37332   1.000 22.10480 ? 101 TYR B CE1 1 
ATOM   3100 C  CE2 . TYR B 1 101 ? -5.65026  5.00814   7.43047   1.000 20.24218 ? 101 TYR B CE2 1 
ATOM   3101 C  CZ  . TYR B 1 101 ? -6.47655  5.96217   7.98393   1.000 22.27123 ? 101 TYR B CZ  1 
ATOM   3102 O  OH  . TYR B 1 101 ? -6.12863  6.57775   9.15119   1.000 25.80346 ? 101 TYR B OH  1 
ATOM   3103 N  N   . LYS B 1 102 ? -6.74019  1.29348   5.25084   1.000 22.25779 ? 102 LYS B N   1 
ATOM   3104 C  CA  . LYS B 1 102 ? -5.83926  0.73624   6.23947   1.000 23.93528 ? 102 LYS B CA  1 
ATOM   3105 C  C   . LYS B 1 102 ? -4.42723  0.75187   5.67678   1.000 20.54582 ? 102 LYS B C   1 
ATOM   3106 O  O   . LYS B 1 102 ? -4.21875  0.89389   4.46856   1.000 20.72822 ? 102 LYS B O   1 
ATOM   3107 C  CB  . LYS B 1 102 ? -6.27022  -0.67090  6.66451   1.000 28.63402 ? 102 LYS B CB  1 
ATOM   3108 C  CG  . LYS B 1 102 ? -6.62660  -1.60597  5.53977   1.000 31.48188 ? 102 LYS B CG  1 
ATOM   3109 C  CD  . LYS B 1 102 ? -7.26228  -2.86505  6.11606   1.000 34.60819 ? 102 LYS B CD  1 
ATOM   3110 C  CE  . LYS B 1 102 ? -7.50364  -3.91529  5.05156   1.000 42.91057 ? 102 LYS B CE  1 
ATOM   3111 N  NZ  . LYS B 1 102 ? -8.26988  -5.07017  5.60872   1.000 48.49415 ? 102 LYS B NZ  1 
ATOM   3112 N  N   . PHE B 1 103 ? -3.45939  0.63971   6.57925   1.000 19.21224 ? 103 PHE B N   1 
ATOM   3113 C  CA  . PHE B 1 103 ? -2.04969  0.52754   6.23402   1.000 18.04356 ? 103 PHE B CA  1 
ATOM   3114 C  C   . PHE B 1 103 ? -1.69682  -0.95226  6.18952   1.000 19.27276 ? 103 PHE B C   1 
ATOM   3115 O  O   . PHE B 1 103 ? -1.94828  -1.67494  7.15691   1.000 21.02997 ? 103 PHE B O   1 
ATOM   3116 C  CB  . PHE B 1 103 ? -1.17284  1.24706   7.25826   1.000 19.37728 ? 103 PHE B CB  1 
ATOM   3117 C  CG  . PHE B 1 103 ? -1.35450  2.73948   7.28474   1.000 22.67310 ? 103 PHE B CG  1 
ATOM   3118 C  CD1 . PHE B 1 103 ? -2.00763  3.39673   6.24516   1.000 19.15058 ? 103 PHE B CD1 1 
ATOM   3119 C  CD2 . PHE B 1 103 ? -0.84941  3.49034   8.34597   1.000 22.19747 ? 103 PHE B CD2 1 
ATOM   3120 C  CE1 . PHE B 1 103 ? -2.16328  4.77706   6.27139   1.000 19.96037 ? 103 PHE B CE1 1 
ATOM   3121 C  CE2 . PHE B 1 103 ? -1.00055  4.86910   8.37254   1.000 22.53500 ? 103 PHE B CE2 1 
ATOM   3122 C  CZ  . PHE B 1 103 ? -1.65784  5.51263   7.33712   1.000 18.48469 ? 103 PHE B CZ  1 
ATOM   3123 N  N   . VAL B 1 104 ? -1.13984  -1.40982  5.06590   1.000 16.35902 ? 104 VAL B N   1 
ATOM   3124 C  CA  . VAL B 1 104 ? -0.73388  -2.80064  4.93154   1.000 17.66262 ? 104 VAL B CA  1 
ATOM   3125 C  C   . VAL B 1 104 ? 0.70025   -2.83040  4.42619   1.000 19.59528 ? 104 VAL B C   1 
ATOM   3126 O  O   . VAL B 1 104 ? 1.19833   -1.86959  3.83561   1.000 25.34356 ? 104 VAL B O   1 
ATOM   3127 C  CB  . VAL B 1 104 ? -1.65843  -3.60619  3.99427   1.000 20.31068 ? 104 VAL B CB  1 
ATOM   3128 C  CG1 . VAL B 1 104 ? -3.11861  -3.49233  4.45122   1.000 21.95330 ? 104 VAL B CG1 1 
ATOM   3129 C  CG2 . VAL B 1 104 ? -1.50101  -3.13350  2.55844   1.000 23.21249 ? 104 VAL B CG2 1 
ATOM   3130 N  N   . ARG B 1 105 ? 1.38005   -3.93687  4.69132   1.000 18.09592 ? 105 ARG B N   1 
ATOM   3131 C  CA  . ARG B 1 105 ? 2.71098   -4.16253  4.14446   1.000 20.04797 ? 105 ARG B CA  1 
ATOM   3132 C  C   . ARG B 1 105 ? 2.62194   -5.29177  3.13014   1.000 20.07359 ? 105 ARG B C   1 
ATOM   3133 O  O   . ARG B 1 105 ? 2.11908   -6.37064  3.45232   1.000 25.26434 ? 105 ARG B O   1 
ATOM   3134 C  CB  . ARG B 1 105 ? 3.72452   -4.49906  5.24333   1.000 20.74316 ? 105 ARG B CB  1 
ATOM   3135 C  CG  . ARG B 1 105 ? 5.15885   -4.60623  4.72347   1.000 21.23749 ? 105 ARG B CG  1 
ATOM   3136 C  CD  . ARG B 1 105 ? 6.17413   -4.64926  5.85663   1.000 22.75923 ? 105 ARG B CD  1 
ATOM   3137 N  NE  . ARG B 1 105 ? 7.53476   -4.87660  5.37509   1.000 20.56790 ? 105 ARG B NE  1 
ATOM   3138 C  CZ  . ARG B 1 105 ? 8.38398   -3.91642  5.03671   1.000 20.45542 ? 105 ARG B CZ  1 
ATOM   3139 N  NH1 . ARG B 1 105 ? 8.03489   -2.64265  5.06918   1.000 16.94304 ? 105 ARG B NH1 1 
ATOM   3140 N  NH2 . ARG B 1 105 ? 9.62017   -4.24397  4.66217   1.000 21.65431 ? 105 ARG B NH2 1 
ATOM   3141 N  N   . ILE B 1 106 ? 3.08995   -5.05059  1.91378   1.000 17.57148 ? 106 ILE B N   1 
ATOM   3142 C  CA  . ILE B 1 106 ? 2.98877   -6.03986  0.85670   1.000 21.85432 ? 106 ILE B CA  1 
ATOM   3143 C  C   . ILE B 1 106 ? 4.26995   -6.85653  0.79490   1.000 21.72852 ? 106 ILE B C   1 
ATOM   3144 O  O   . ILE B 1 106 ? 5.28783   -6.50912  1.38951   1.000 21.27955 ? 106 ILE B O   1 
ATOM   3145 C  CB  . ILE B 1 106 ? 2.66263   -5.40666  -0.51379  1.000 24.73613 ? 106 ILE B CB  1 
ATOM   3146 C  CG1 . ILE B 1 106 ? 3.65868   -4.30454  -0.84846  1.000 21.46240 ? 106 ILE B CG1 1 
ATOM   3147 C  CG2 . ILE B 1 106 ? 1.21876   -4.90757  -0.54239  1.000 23.90817 ? 106 ILE B CG2 1 
ATOM   3148 C  CD1 . ILE B 1 106 ? 3.70391   -3.98028  -2.30629  1.000 24.82044 ? 106 ILE B CD1 1 
ATOM   3149 N  N   . GLN B 1 107 ? 4.21215   -7.95965  0.08969   1.000 24.69319 ? 107 GLN B N   1 
ATOM   3150 C  CA  . GLN B 1 107 ? 5.27263   -8.91154  -0.18069  1.000 28.95298 ? 107 GLN B CA  1 
ATOM   3151 C  C   . GLN B 1 107 ? 5.85231   -8.67569  -1.56788  1.000 26.27421 ? 107 GLN B C   1 
ATOM   3152 O  O   . GLN B 1 107 ? 5.12155   -8.29663  -2.48988  1.000 23.14820 ? 107 GLN B O   1 
ATOM   3153 C  CB  . GLN B 1 107 ? 4.73825   -10.34281 -0.10616  1.000 32.08918 ? 107 GLN B CB  1 
ATOM   3154 C  CG  . GLN B 1 107 ? 3.74886   -10.56218 1.02396   1.000 39.96445 ? 107 GLN B CG  1 
ATOM   3155 C  CD  . GLN B 1 107 ? 4.39498   -11.19511 2.23031   1.000 51.71901 ? 107 GLN B CD  1 
ATOM   3156 O  OE1 . GLN B 1 107 ? 4.82202   -12.35079 2.18333   1.000 57.30839 ? 107 GLN B OE1 1 
ATOM   3157 N  NE2 . GLN B 1 107 ? 4.47937   -10.44111 3.32168   1.000 55.31150 ? 107 GLN B NE2 1 
ATOM   3158 N  N   . PRO B 1 108 ? 7.15677   -8.89884  -1.75755  1.000 29.36563 ? 108 PRO B N   1 
ATOM   3159 C  CA  . PRO B 1 108 ? 7.72200   -8.79310  -3.10740  1.000 22.46183 ? 108 PRO B CA  1 
ATOM   3160 C  C   . PRO B 1 108 ? 6.96901   -9.71674  -4.04934  1.000 24.03709 ? 108 PRO B C   1 
ATOM   3161 O  O   . PRO B 1 108 ? 6.49234   -10.78215 -3.65383  1.000 23.81443 ? 108 PRO B O   1 
ATOM   3162 C  CB  . PRO B 1 108 ? 9.18582   -9.21906  -2.92778  1.000 27.43621 ? 108 PRO B CB  1 
ATOM   3163 C  CG  . PRO B 1 108 ? 9.23097   -9.95106  -1.62274  1.000 31.35186 ? 108 PRO B CG  1 
ATOM   3164 C  CD  . PRO B 1 108 ? 8.15037   -9.35564  -0.76978  1.000 24.75713 ? 108 PRO B CD  1 
ATOM   3165 N  N   . GLY B 1 109 ? 6.81478   -9.27128  -5.29627  1.000 23.31257 ? 109 GLY B N   1 
ATOM   3166 C  CA  . GLY B 1 109 ? 5.97911   -9.96217  -6.25419  1.000 21.27518 ? 109 GLY B CA  1 
ATOM   3167 C  C   . GLY B 1 109 ? 4.53686   -9.50206  -6.28587  1.000 24.04123 ? 109 GLY B C   1 
ATOM   3168 O  O   . GLY B 1 109 ? 3.81871   -9.81759  -7.24055  1.000 24.15819 ? 109 GLY B O   1 
ATOM   3169 N  N   . GLN B 1 110 ? 4.08338   -8.77776  -5.27258  1.000 23.04206 ? 110 GLN B N   1 
ATOM   3170 C  CA  . GLN B 1 110 ? 2.72594   -8.25738  -5.27222  1.000 20.31701 ? 110 GLN B CA  1 
ATOM   3171 C  C   . GLN B 1 110 ? 2.70689   -6.91478  -5.98955  1.000 21.32514 ? 110 GLN B C   1 
ATOM   3172 O  O   . GLN B 1 110 ? 3.71882   -6.21267  -6.05342  1.000 19.97532 ? 110 GLN B O   1 
ATOM   3173 C  CB  . GLN B 1 110 ? 2.18528   -8.12592  -3.84387  1.000 20.21536 ? 110 GLN B CB  1 
ATOM   3174 C  CG  . GLN B 1 110 ? 1.98193   -9.48454  -3.16466  1.000 29.37774 ? 110 GLN B CG  1 
ATOM   3175 C  CD  . GLN B 1 110 ? 1.26677   -9.39869  -1.81203  1.000 36.26537 ? 110 GLN B CD  1 
ATOM   3176 O  OE1 . GLN B 1 110 ? 1.72366   -8.72503  -0.88652  1.000 32.63874 ? 110 GLN B OE1 1 
ATOM   3177 N  NE2 . GLN B 1 110 ? 0.14212   -10.09594 -1.69712  1.000 39.19201 ? 110 GLN B NE2 1 
ATOM   3178 N  N   . THR B 1 111 ? 1.54946   -6.57460  -6.55108  1.000 20.89650 ? 111 THR B N   1 
ATOM   3179 C  CA  . THR B 1 111 ? 1.40931   -5.39723  -7.39740  1.000 20.13423 ? 111 THR B CA  1 
ATOM   3180 C  C   . THR B 1 111 ? 0.56850   -4.34395  -6.68916  1.000 19.52155 ? 111 THR B C   1 
ATOM   3181 O  O   . THR B 1 111 ? -0.16487  -4.64221  -5.74383  1.000 17.80332 ? 111 THR B O   1 
ATOM   3182 C  CB  . THR B 1 111 ? 0.75690   -5.75169  -8.73512  1.000 20.07544 ? 111 THR B CB  1 
ATOM   3183 O  OG1 . THR B 1 111 ? -0.50513  -6.37220  -8.47745  1.000 17.63500 ? 111 THR B OG1 1 
ATOM   3184 C  CG2 . THR B 1 111 ? 1.64873   -6.69556  -9.53720  1.000 20.41244 ? 111 THR B CG2 1 
ATOM   3185 N  N   . PHE B 1 112 ? 0.67858   -3.10634  -7.16428  1.000 17.26629 ? 112 PHE B N   1 
ATOM   3186 C  CA  . PHE B 1 112 ? -0.09414  -2.00616  -6.60224  1.000 18.04646 ? 112 PHE B CA  1 
ATOM   3187 C  C   . PHE B 1 112 ? -0.02603  -0.83094  -7.56199  1.000 16.78318 ? 112 PHE B C   1 
ATOM   3188 O  O   . PHE B 1 112 ? 0.81602   -0.79180  -8.45789  1.000 16.72685 ? 112 PHE B O   1 
ATOM   3189 C  CB  . PHE B 1 112 ? 0.41486   -1.60453  -5.21186  1.000 15.47463 ? 112 PHE B CB  1 
ATOM   3190 C  CG  . PHE B 1 112 ? 1.87050   -1.18938  -5.17823  1.000 16.56146 ? 112 PHE B CG  1 
ATOM   3191 C  CD1 . PHE B 1 112 ? 2.87426   -2.13882  -5.07979  1.000 17.87730 ? 112 PHE B CD1 1 
ATOM   3192 C  CD2 . PHE B 1 112 ? 2.22685   0.14717   -5.19770  1.000 16.22460 ? 112 PHE B CD2 1 
ATOM   3193 C  CE1 . PHE B 1 112 ? 4.21069   -1.76487  -5.01655  1.000 21.63636 ? 112 PHE B CE1 1 
ATOM   3194 C  CE2 . PHE B 1 112 ? 3.56079   0.53028   -5.13386  1.000 20.62027 ? 112 PHE B CE2 1 
ATOM   3195 C  CZ  . PHE B 1 112 ? 4.55744   -0.42820  -5.04452  1.000 20.20087 ? 112 PHE B CZ  1 
ATOM   3196 N  N   . SER B 1 113 ? -0.92517  0.13176   -7.35618  1.000 15.56303 ? 113 SER B N   1 
ATOM   3197 C  CA  . SER B 1 113 ? -0.94868  1.36012   -8.13445  1.000 18.98603 ? 113 SER B CA  1 
ATOM   3198 C  C   . SER B 1 113 ? -0.23954  2.47836   -7.38210  1.000 17.63249 ? 113 SER B C   1 
ATOM   3199 O  O   . SER B 1 113 ? -0.39309  2.61731   -6.16687  1.000 15.77199 ? 113 SER B O   1 
ATOM   3200 C  CB  . SER B 1 113 ? -2.38131  1.78790   -8.43828  1.000 15.19944 ? 113 SER B CB  1 
ATOM   3201 O  OG  . SER B 1 113 ? -3.06026  0.77240   -9.14446  1.000 20.06253 ? 113 SER B OG  1 
ATOM   3202 N  N   . VAL B 1 114 ? 0.51493   3.28422   -8.12020  1.000 17.48632 ? 114 VAL B N   1 
ATOM   3203 C  CA  . VAL B 1 114 ? 1.22285   4.44242   -7.58790  1.000 19.61978 ? 114 VAL B CA  1 
ATOM   3204 C  C   . VAL B 1 114 ? 0.55037   5.68923   -8.13755  1.000 21.13189 ? 114 VAL B C   1 
ATOM   3205 O  O   . VAL B 1 114 ? 0.36524   5.81194   -9.35236  1.000 20.72455 ? 114 VAL B O   1 
ATOM   3206 C  CB  . VAL B 1 114 ? 2.70841   4.42004   -7.98298  1.000 22.74933 ? 114 VAL B CB  1 
ATOM   3207 C  CG1 . VAL B 1 114 ? 3.36542   5.75975   -7.66844  1.000 22.02613 ? 114 VAL B CG1 1 
ATOM   3208 C  CG2 . VAL B 1 114 ? 3.43384   3.27517   -7.29188  1.000 22.76147 ? 114 VAL B CG2 1 
ATOM   3209 N  N   . LEU B 1 115 ? 0.19899   6.61716   -7.25769  1.000 19.87657 ? 115 LEU B N   1 
ATOM   3210 C  CA  . LEU B 1 115 ? -0.33664  7.91049   -7.68215  1.000 19.15533 ? 115 LEU B CA  1 
ATOM   3211 C  C   . LEU B 1 115 ? 0.81278   8.91222   -7.60158  1.000 20.58782 ? 115 LEU B C   1 
ATOM   3212 O  O   . LEU B 1 115 ? 1.09335   9.48286   -6.54692  1.000 19.48255 ? 115 LEU B O   1 
ATOM   3213 C  CB  . LEU B 1 115 ? -1.52552  8.32994   -6.82511  1.000 19.32176 ? 115 LEU B CB  1 
ATOM   3214 C  CG  . LEU B 1 115 ? -2.17947  9.64650   -7.24927  1.000 22.69100 ? 115 LEU B CG  1 
ATOM   3215 C  CD1 . LEU B 1 115 ? -2.78262  9.52852   -8.64659  1.000 19.25282 ? 115 LEU B CD1 1 
ATOM   3216 C  CD2 . LEU B 1 115 ? -3.23253  10.08695  -6.23284  1.000 19.61749 ? 115 LEU B CD2 1 
ATOM   3217 N  N   . ALA B 1 116 ? 1.48537   9.12509   -8.73107  1.000 19.07957 ? 116 ALA B N   1 
ATOM   3218 C  CA  . ALA B 1 116 ? 2.62523   10.03612  -8.74812  1.000 21.02671 ? 116 ALA B CA  1 
ATOM   3219 C  C   . ALA B 1 116 ? 2.13533   11.46901  -8.59512  1.000 22.83865 ? 116 ALA B C   1 
ATOM   3220 O  O   . ALA B 1 116 ? 1.20904   11.89359  -9.29640  1.000 24.35949 ? 116 ALA B O   1 
ATOM   3221 C  CB  . ALA B 1 116 ? 3.42667   9.87592   -10.03738 1.000 20.27074 ? 116 ALA B CB  1 
ATOM   3222 N  N   . CYS B 1 117 ? 2.74636   12.20205  -7.65895  1.000 24.46745 ? 117 CYS B N   1 
ATOM   3223 C  CA  . CYS B 1 117 ? 2.32622   13.54706  -7.28677  1.000 22.84981 ? 117 CYS B CA  1 
ATOM   3224 C  C   . CYS B 1 117 ? 3.51934   14.48462  -7.23877  1.000 24.77234 ? 117 CYS B C   1 
ATOM   3225 O  O   . CYS B 1 117 ? 4.66476   14.05995  -7.06009  1.000 25.07311 ? 117 CYS B O   1 
ATOM   3226 C  CB  . CYS B 1 117 ? 1.64612   13.58010  -5.91582  1.000 24.97195 ? 117 CYS B CB  1 
ATOM   3227 S  SG  . CYS B 1 117 ? 0.18894   12.60117  -5.80455  1.000 28.43986 ? 117 CYS B SG  1 
ATOM   3228 N  N   . TYR B 1 118 ? 3.22168   15.77670  -7.38346  1.000 27.24512 ? 118 TYR B N   1 
ATOM   3229 C  CA  . TYR B 1 118 ? 4.22178   16.83583  -7.32819  1.000 28.11810 ? 118 TYR B CA  1 
ATOM   3230 C  C   . TYR B 1 118 ? 3.56492   18.06621  -6.72593  1.000 29.37234 ? 118 TYR B C   1 
ATOM   3231 O  O   . TYR B 1 118 ? 2.50081   18.48478  -7.19175  1.000 31.57421 ? 118 TYR B O   1 
ATOM   3232 C  CB  . TYR B 1 118 ? 4.78730   17.14261  -8.72075  1.000 25.05353 ? 118 TYR B CB  1 
ATOM   3233 C  CG  . TYR B 1 118 ? 5.45883   15.93981  -9.34470  1.000 31.54266 ? 118 TYR B CG  1 
ATOM   3234 C  CD1 . TYR B 1 118 ? 6.81423   15.68367  -9.14024  1.000 30.09854 ? 118 TYR B CD1 1 
ATOM   3235 C  CD2 . TYR B 1 118 ? 4.73072   15.03392  -10.11123 1.000 29.45392 ? 118 TYR B CD2 1 
ATOM   3236 C  CE1 . TYR B 1 118 ? 7.41755   14.56887  -9.69492  1.000 28.62000 ? 118 TYR B CE1 1 
ATOM   3237 C  CE2 . TYR B 1 118 ? 5.32539   13.92026  -10.65731 1.000 24.58680 ? 118 TYR B CE2 1 
ATOM   3238 C  CZ  . TYR B 1 118 ? 6.66114   13.69647  -10.45530 1.000 26.02303 ? 118 TYR B CZ  1 
ATOM   3239 O  OH  . TYR B 1 118 ? 7.23285   12.58633  -11.01507 1.000 29.25010 ? 118 TYR B OH  1 
ATOM   3240 N  N   . ASN B 1 119 ? 4.19333   18.62603  -5.68809  1.000 33.31113 ? 119 ASN B N   1 
ATOM   3241 C  CA  . ASN B 1 119 ? 3.63639   19.75694  -4.93170  1.000 34.22052 ? 119 ASN B CA  1 
ATOM   3242 C  C   . ASN B 1 119 ? 2.20743   19.47409  -4.47421  1.000 35.30915 ? 119 ASN B C   1 
ATOM   3243 O  O   . ASN B 1 119 ? 1.31967   20.32386  -4.56925  1.000 33.18471 ? 119 ASN B O   1 
ATOM   3244 C  CB  . ASN B 1 119 ? 3.69625   21.04883  -5.74447  1.000 39.46699 ? 119 ASN B CB  1 
ATOM   3245 C  CG  . ASN B 1 119 ? 5.11142   21.44303  -6.09300  1.000 43.18982 ? 119 ASN B CG  1 
ATOM   3246 O  OD1 . ASN B 1 119 ? 5.91919   21.73814  -5.20848  1.000 41.23175 ? 119 ASN B OD1 1 
ATOM   3247 N  ND2 . ASN B 1 119 ? 5.42509   21.44845  -7.38609  1.000 47.11650 ? 119 ASN B ND2 1 
ATOM   3248 N  N   . GLY B 1 120 ? 1.98357   18.26297  -3.96612  1.000 30.72057 ? 120 GLY B N   1 
ATOM   3249 C  CA  . GLY B 1 120 ? 0.66544   17.85942  -3.53867  1.000 25.27967 ? 120 GLY B CA  1 
ATOM   3250 C  C   . GLY B 1 120 ? -0.33986  17.63349  -4.64461  1.000 28.38901 ? 120 GLY B C   1 
ATOM   3251 O  O   . GLY B 1 120 ? -1.49710  17.31356  -4.34646  1.000 32.12910 ? 120 GLY B O   1 
ATOM   3252 N  N   . SER B 1 121 ? 0.04979   17.77437  -5.90903  1.000 28.08094 ? 121 SER B N   1 
ATOM   3253 C  CA  . SER B 1 121 ? -0.90554  17.66979  -7.00283  1.000 31.23839 ? 121 SER B CA  1 
ATOM   3254 C  C   . SER B 1 121 ? -0.73098  16.35495  -7.74741  1.000 26.06246 ? 121 SER B C   1 
ATOM   3255 O  O   . SER B 1 121 ? 0.36081   16.08476  -8.26467  1.000 25.55471 ? 121 SER B O   1 
ATOM   3256 C  CB  . SER B 1 121 ? -0.74523  18.84412  -7.96034  1.000 30.63159 ? 121 SER B CB  1 
ATOM   3257 O  OG  . SER B 1 121 ? -1.68302  18.74117  -9.01644  1.000 38.14357 ? 121 SER B OG  1 
ATOM   3258 N  N   . PRO B 1 122 ? -1.75663  15.51149  -7.82266  1.000 29.05130 ? 122 PRO B N   1 
ATOM   3259 C  CA  . PRO B 1 122 ? -1.63603  14.26667  -8.59481  1.000 26.32160 ? 122 PRO B CA  1 
ATOM   3260 C  C   . PRO B 1 122 ? -1.39222  14.54104  -10.07245 1.000 29.60582 ? 122 PRO B C   1 
ATOM   3261 O  O   . PRO B 1 122 ? -2.08438  15.34896  -10.69760 1.000 28.49265 ? 122 PRO B O   1 
ATOM   3262 C  CB  . PRO B 1 122 ? -2.98819  13.58341  -8.36718  1.000 26.15736 ? 122 PRO B CB  1 
ATOM   3263 C  CG  . PRO B 1 122 ? -3.47010  14.14313  -7.06719  1.000 26.19028 ? 122 PRO B CG  1 
ATOM   3264 C  CD  . PRO B 1 122 ? -3.01174  15.56808  -7.05768  1.000 24.44904 ? 122 PRO B CD  1 
ATOM   3265 N  N   . SER B 1 123 ? -0.40610  13.85263  -10.63758 1.000 22.97759 ? 123 SER B N   1 
ATOM   3266 C  CA  . SER B 1 123 ? -0.10812  14.01306  -12.04963 1.000 26.54636 ? 123 SER B CA  1 
ATOM   3267 C  C   . SER B 1 123 ? -0.33039  12.75991  -12.88148 1.000 23.39899 ? 123 SER B C   1 
ATOM   3268 O  O   . SER B 1 123 ? -0.61880  12.88139  -14.07103 1.000 25.75573 ? 123 SER B O   1 
ATOM   3269 C  CB  . SER B 1 123 ? 1.33944   14.48526  -12.24030 1.000 28.24576 ? 123 SER B CB  1 
ATOM   3270 O  OG  . SER B 1 123 ? 2.23336   13.59165  -11.60719 1.000 38.72241 ? 123 SER B OG  1 
ATOM   3271 N  N   . GLY B 1 124 ? -0.21266  11.57196  -12.30076 1.000 24.13009 ? 124 GLY B N   1 
ATOM   3272 C  CA  . GLY B 1 124 ? -0.40846  10.35026  -13.05798 1.000 21.82746 ? 124 GLY B CA  1 
ATOM   3273 C  C   . GLY B 1 124 ? -0.51079  9.15015   -12.14555 1.000 19.83304 ? 124 GLY B C   1 
ATOM   3274 O  O   . GLY B 1 124 ? -0.08944  9.18550   -10.98646 1.000 20.18200 ? 124 GLY B O   1 
ATOM   3275 N  N   . VAL B 1 125 ? -1.08371  8.08354   -12.68491 1.000 18.59217 ? 125 VAL B N   1 
ATOM   3276 C  CA  . VAL B 1 125 ? -1.22994  6.83661   -11.95048 1.000 19.08858 ? 125 VAL B CA  1 
ATOM   3277 C  C   . VAL B 1 125 ? -0.71061  5.70868   -12.82656 1.000 20.56879 ? 125 VAL B C   1 
ATOM   3278 O  O   . VAL B 1 125 ? -0.94213  5.69529   -14.03919 1.000 19.39289 ? 125 VAL B O   1 
ATOM   3279 C  CB  . VAL B 1 125 ? -2.69173  6.58593   -11.51696 1.000 20.69138 ? 125 VAL B CB  1 
ATOM   3280 C  CG1 . VAL B 1 125 ? -3.62751  6.50619   -12.72720 1.000 20.35642 ? 125 VAL B CG1 1 
ATOM   3281 C  CG2 . VAL B 1 125 ? -2.78447  5.32350   -10.66887 1.000 20.61525 ? 125 VAL B CG2 1 
ATOM   3282 N  N   . TYR B 1 126 ? 0.01537   4.77409   -12.21952 1.000 20.55485 ? 126 TYR B N   1 
ATOM   3283 C  CA  . TYR B 1 126 ? 0.49367   3.62506   -12.96953 1.000 18.53020 ? 126 TYR B CA  1 
ATOM   3284 C  C   . TYR B 1 126 ? 0.55048   2.41677   -12.05045 1.000 20.56528 ? 126 TYR B C   1 
ATOM   3285 O  O   . TYR B 1 126 ? 0.65502   2.54109   -10.82771 1.000 17.31181 ? 126 TYR B O   1 
ATOM   3286 C  CB  . TYR B 1 126 ? 1.86359   3.88682   -13.61513 1.000 21.12630 ? 126 TYR B CB  1 
ATOM   3287 C  CG  . TYR B 1 126 ? 2.97429   4.26005   -12.65834 1.000 26.96104 ? 126 TYR B CG  1 
ATOM   3288 C  CD1 . TYR B 1 126 ? 3.22699   5.58721   -12.34161 1.000 26.45038 ? 126 TYR B CD1 1 
ATOM   3289 C  CD2 . TYR B 1 126 ? 3.78790   3.28537   -12.09002 1.000 28.37467 ? 126 TYR B CD2 1 
ATOM   3290 C  CE1 . TYR B 1 126 ? 4.25215   5.93415   -11.46926 1.000 28.03595 ? 126 TYR B CE1 1 
ATOM   3291 C  CE2 . TYR B 1 126 ? 4.81166   3.62274   -11.22492 1.000 26.55396 ? 126 TYR B CE2 1 
ATOM   3292 C  CZ  . TYR B 1 126 ? 5.03474   4.94952   -10.91409 1.000 29.50224 ? 126 TYR B CZ  1 
ATOM   3293 O  OH  . TYR B 1 126 ? 6.05603   5.29072   -10.05720 1.000 34.90606 ? 126 TYR B OH  1 
ATOM   3294 N  N   . GLN B 1 127 ? 0.47349   1.24375   -12.66714 1.000 19.56503 ? 127 GLN B N   1 
ATOM   3295 C  CA  . GLN B 1 127 ? 0.49546   -0.03627  -11.97398 1.000 17.83591 ? 127 GLN B CA  1 
ATOM   3296 C  C   . GLN B 1 127 ? 1.91574   -0.58482  -11.99808 1.000 23.17696 ? 127 GLN B C   1 
ATOM   3297 O  O   . GLN B 1 127 ? 2.60832   -0.48143  -13.01341 1.000 22.07886 ? 127 GLN B O   1 
ATOM   3298 C  CB  . GLN B 1 127 ? -0.47109  -1.01441  -12.65312 1.000 20.24626 ? 127 GLN B CB  1 
ATOM   3299 C  CG  . GLN B 1 127 ? -0.62344  -2.37282  -11.99947 1.000 20.08112 ? 127 GLN B CG  1 
ATOM   3300 C  CD  . GLN B 1 127 ? -1.43889  -2.33867  -10.73161 1.000 19.74633 ? 127 GLN B CD  1 
ATOM   3301 O  OE1 . GLN B 1 127 ? -1.85688  -1.27330  -10.26237 1.000 20.65215 ? 127 GLN B OE1 1 
ATOM   3302 N  NE2 . GLN B 1 127 ? -1.66623  -3.51053  -10.15386 1.000 21.64618 ? 127 GLN B NE2 1 
ATOM   3303 N  N   . CYS B 1 128 ? 2.35865   -1.14806  -10.87559 1.000 22.89052 ? 128 CYS B N   1 
ATOM   3304 C  CA  . CYS B 1 128 ? 3.69622   -1.72554  -10.82329 1.000 26.21796 ? 128 CYS B CA  1 
ATOM   3305 C  C   . CYS B 1 128 ? 3.72184   -2.85364  -9.80405  1.000 21.89895 ? 128 CYS B C   1 
ATOM   3306 O  O   . CYS B 1 128 ? 2.77187   -3.06471  -9.05337  1.000 23.23668 ? 128 CYS B O   1 
ATOM   3307 C  CB  . CYS B 1 128 ? 4.75434   -0.67600  -10.47606 1.000 24.03215 ? 128 CYS B CB  1 
ATOM   3308 S  SG  . CYS B 1 128 ? 4.57759   0.00282   -8.82646  1.000 31.46610 ? 128 CYS B SG  1 
ATOM   3309 N  N   . ALA B 1 129 ? 4.83669   -3.57306  -9.78437  1.000 23.02410 ? 129 ALA B N   1 
ATOM   3310 C  CA  . ALA B 1 129 ? 5.06242   -4.66324  -8.85402  1.000 21.24889 ? 129 ALA B CA  1 
ATOM   3311 C  C   . ALA B 1 129 ? 6.23624   -4.32574  -7.94443  1.000 20.96485 ? 129 ALA B C   1 
ATOM   3312 O  O   . ALA B 1 129 ? 7.17901   -3.64024  -8.34572  1.000 23.70441 ? 129 ALA B O   1 
ATOM   3313 C  CB  . ALA B 1 129 ? 5.34108   -5.98070  -9.59483  1.000 19.72157 ? 129 ALA B CB  1 
ATOM   3314 N  N   . MET B 1 130 ? 6.16246   -4.80762  -6.71038  1.000 21.32130 ? 130 MET B N   1 
ATOM   3315 C  CA  . MET B 1 130 ? 7.30031   -4.77575  -5.79885  1.000 21.46767 ? 130 MET B CA  1 
ATOM   3316 C  C   . MET B 1 130 ? 8.29867   -5.84125  -6.24298  1.000 20.32114 ? 130 MET B C   1 
ATOM   3317 O  O   . MET B 1 130 ? 7.96331   -7.02897  -6.26256  1.000 20.30323 ? 130 MET B O   1 
ATOM   3318 C  CB  . MET B 1 130 ? 6.80630   -5.01827  -4.37355  1.000 20.42213 ? 130 MET B CB  1 
ATOM   3319 C  CG  . MET B 1 130 ? 7.86138   -5.25809  -3.29620  1.000 26.00719 ? 130 MET B CG  1 
ATOM   3320 S  SD  . MET B 1 130 ? 8.57413   -3.75533  -2.60744  1.000 32.60871 ? 130 MET B SD  1 
ATOM   3321 C  CE  . MET B 1 130 ? 7.12208   -2.79880  -2.15973  1.000 19.07893 ? 130 MET B CE  1 
ATOM   3322 N  N   . ARG B 1 131 ? 9.50871   -5.42532  -6.62746  1.000 18.83964 ? 131 ARG B N   1 
ATOM   3323 C  CA  . ARG B 1 131 ? 10.46397  -6.37788  -7.17504  1.000 19.71403 ? 131 ARG B CA  1 
ATOM   3324 C  C   . ARG B 1 131 ? 10.91714  -7.35139  -6.08734  1.000 21.86956 ? 131 ARG B C   1 
ATOM   3325 O  O   . ARG B 1 131 ? 10.88687  -7.02558  -4.89949  1.000 19.74990 ? 131 ARG B O   1 
ATOM   3326 C  CB  . ARG B 1 131 ? 11.69199  -5.67405  -7.75781  1.000 21.99821 ? 131 ARG B CB  1 
ATOM   3327 C  CG  . ARG B 1 131 ? 11.43846  -4.70416  -8.92604  1.000 26.75892 ? 131 ARG B CG  1 
ATOM   3328 C  CD  . ARG B 1 131 ? 10.55751  -5.29175  -10.02620 1.000 26.55893 ? 131 ARG B CD  1 
ATOM   3329 N  NE  . ARG B 1 131 ? 11.07709  -6.54902  -10.55035 1.000 20.85113 ? 131 ARG B NE  1 
ATOM   3330 C  CZ  . ARG B 1 131 ? 10.38321  -7.37634  -11.31706 1.000 24.67039 ? 131 ARG B CZ  1 
ATOM   3331 N  NH1 . ARG B 1 131 ? 9.15819   -7.07449  -11.72989 1.000 18.25577 ? 131 ARG B NH1 1 
ATOM   3332 N  NH2 . ARG B 1 131 ? 10.92387  -8.54029  -11.66764 1.000 21.54346 ? 131 ARG B NH2 1 
ATOM   3333 N  N   . PRO B 1 132 ? 11.34588  -8.55382  -6.46988  1.000 26.57795 ? 132 PRO B N   1 
ATOM   3334 C  CA  . PRO B 1 132 ? 11.96856  -9.45763  -5.48668  1.000 23.01127 ? 132 PRO B CA  1 
ATOM   3335 C  C   . PRO B 1 132 ? 13.11999  -8.83513  -4.71941  1.000 19.95323 ? 132 PRO B C   1 
ATOM   3336 O  O   . PRO B 1 132 ? 13.38030  -9.24818  -3.57928  1.000 22.45591 ? 132 PRO B O   1 
ATOM   3337 C  CB  . PRO B 1 132 ? 12.44311  -10.63322 -6.35308  1.000 23.72034 ? 132 PRO B CB  1 
ATOM   3338 C  CG  . PRO B 1 132 ? 11.46271  -10.65703 -7.47979  1.000 27.16014 ? 132 PRO B CG  1 
ATOM   3339 C  CD  . PRO B 1 132 ? 11.18279  -9.20049  -7.78398  1.000 22.62127 ? 132 PRO B CD  1 
ATOM   3340 N  N   . ASN B 1 133 ? 13.82005  -7.85794  -5.29458  1.000 20.68107 ? 133 ASN B N   1 
ATOM   3341 C  CA  . ASN B 1 133 ? 14.88633  -7.16537  -4.57830  1.000 23.49665 ? 133 ASN B CA  1 
ATOM   3342 C  C   . ASN B 1 133 ? 14.37949  -5.92938  -3.85024  1.000 22.78737 ? 133 ASN B C   1 
ATOM   3343 O  O   . ASN B 1 133 ? 15.17946  -5.05378  -3.49316  1.000 21.66364 ? 133 ASN B O   1 
ATOM   3344 C  CB  . ASN B 1 133 ? 16.04404  -6.81514  -5.52660  1.000 18.83008 ? 133 ASN B CB  1 
ATOM   3345 C  CG  . ASN B 1 133 ? 15.72853  -5.67793  -6.49165  1.000 24.42419 ? 133 ASN B CG  1 
ATOM   3346 O  OD1 . ASN B 1 133 ? 14.63580  -5.11277  -6.49632  1.000 19.60586 ? 133 ASN B OD1 1 
ATOM   3347 N  ND2 . ASN B 1 133 ? 16.71644  -5.32864  -7.31846  1.000 25.07972 ? 133 ASN B ND2 1 
ATOM   3348 N  N   . PHE B 1 134 ? 13.06203  -5.83801  -3.65399  1.000 22.56394 ? 134 PHE B N   1 
ATOM   3349 C  CA  . PHE B 1 134 ? 12.36391  -4.82443  -2.86592  1.000 22.85198 ? 134 PHE B CA  1 
ATOM   3350 C  C   . PHE B 1 134 ? 12.43483  -3.42950  -3.46132  1.000 21.54277 ? 134 PHE B C   1 
ATOM   3351 O  O   . PHE B 1 134 ? 12.06650  -2.45822  -2.78689  1.000 25.34926 ? 134 PHE B O   1 
ATOM   3352 C  CB  . PHE B 1 134 ? 12.85794  -4.76285  -1.42072  1.000 18.72145 ? 134 PHE B CB  1 
ATOM   3353 C  CG  . PHE B 1 134 ? 12.50523  -5.96655  -0.60665  1.000 21.11032 ? 134 PHE B CG  1 
ATOM   3354 C  CD1 . PHE B 1 134 ? 11.24379  -6.09515  -0.04921  1.000 21.99947 ? 134 PHE B CD1 1 
ATOM   3355 C  CD2 . PHE B 1 134 ? 13.44096  -6.97163  -0.39307  1.000 20.69788 ? 134 PHE B CD2 1 
ATOM   3356 C  CE1 . PHE B 1 134 ? 10.91202  -7.20092  0.71091   1.000 22.09691 ? 134 PHE B CE1 1 
ATOM   3357 C  CE2 . PHE B 1 134 ? 13.11499  -8.08706  0.35120   1.000 20.77044 ? 134 PHE B CE2 1 
ATOM   3358 C  CZ  . PHE B 1 134 ? 11.84837  -8.20189  0.90883   1.000 24.94882 ? 134 PHE B CZ  1 
ATOM   3359 N  N   . THR B 1 135 ? 12.86637  -3.28900  -4.70023  1.000 20.85469 ? 135 THR B N   1 
ATOM   3360 C  CA  . THR B 1 135 ? 12.74116  -1.99283  -5.33809  1.000 20.41686 ? 135 THR B CA  1 
ATOM   3361 C  C   . THR B 1 135 ? 11.46269  -1.96337  -6.16738  1.000 21.62760 ? 135 THR B C   1 
ATOM   3362 O  O   . THR B 1 135 ? 10.79286  -2.97894  -6.35467  1.000 21.64301 ? 135 THR B O   1 
ATOM   3363 C  CB  . THR B 1 135 ? 13.96825  -1.70586  -6.19077  1.000 21.39067 ? 135 THR B CB  1 
ATOM   3364 O  OG1 . THR B 1 135 ? 13.99754  -2.60920  -7.30137  1.000 23.00271 ? 135 THR B OG1 1 
ATOM   3365 C  CG2 . THR B 1 135 ? 15.22905  -1.89398  -5.33748  1.000 24.76728 ? 135 THR B CG2 1 
ATOM   3366 N  N   . ILE B 1 136 ? 11.09394  -0.78065  -6.63667  1.000 19.05258 ? 136 ILE B N   1 
ATOM   3367 C  CA  . ILE B 1 136 ? 10.05219  -0.67883  -7.64363  1.000 23.53712 ? 136 ILE B CA  1 
ATOM   3368 C  C   . ILE B 1 136 ? 10.62224  0.07828   -8.83687  1.000 24.00429 ? 136 ILE B C   1 
ATOM   3369 O  O   . ILE B 1 136 ? 11.45437  0.98143   -8.68508  1.000 24.35422 ? 136 ILE B O   1 
ATOM   3370 C  CB  . ILE B 1 136 ? 8.75340   -0.03613  -7.10763  1.000 26.31547 ? 136 ILE B CB  1 
ATOM   3371 C  CG1 . ILE B 1 136 ? 8.92649   1.43453   -6.77787  1.000 28.99158 ? 136 ILE B CG1 1 
ATOM   3372 C  CG2 . ILE B 1 136 ? 8.22492   -0.78793  -5.86594  1.000 26.68148 ? 136 ILE B CG2 1 
ATOM   3373 C  CD1 . ILE B 1 136 ? 7.61060   2.07162   -6.34051  1.000 29.31457 ? 136 ILE B CD1 1 
ATOM   3374 N  N   . LYS B 1 137 ? 10.22022  -0.34336  -10.03124 1.000 25.98426 ? 137 LYS B N   1 
ATOM   3375 C  CA  . LYS B 1 137 ? 10.68176  0.28538   -11.26296 1.000 26.24083 ? 137 LYS B CA  1 
ATOM   3376 C  C   . LYS B 1 137 ? 9.66576   1.36044   -11.61612 1.000 28.17941 ? 137 LYS B C   1 
ATOM   3377 O  O   . LYS B 1 137 ? 8.75946   1.16794   -12.42411 1.000 29.11080 ? 137 LYS B O   1 
ATOM   3378 C  CB  . LYS B 1 137 ? 10.83875  -0.74780  -12.37015 1.000 31.55383 ? 137 LYS B CB  1 
ATOM   3379 C  CG  . LYS B 1 137 ? 12.01866  -1.69257  -12.18943 1.000 30.53414 ? 137 LYS B CG  1 
ATOM   3380 C  CD  . LYS B 1 137 ? 11.84208  -2.94016  -13.03686 1.000 38.68636 ? 137 LYS B CD  1 
ATOM   3381 C  CE  . LYS B 1 137 ? 13.16737  -3.58656  -13.37417 1.000 41.81904 ? 137 LYS B CE  1 
ATOM   3382 N  NZ  . LYS B 1 137 ? 14.00890  -2.71001  -14.23277 1.000 46.53776 ? 137 LYS B NZ  1 
ATOM   3383 N  N   . GLY B 1 138 ? 9.81058   2.51481   -10.96741 1.000 27.09833 ? 138 GLY B N   1 
ATOM   3384 C  CA  . GLY B 1 138 ? 8.83678   3.57624   -11.07561 1.000 33.25352 ? 138 GLY B CA  1 
ATOM   3385 C  C   . GLY B 1 138 ? 9.22216   4.62514   -12.10598 1.000 29.98289 ? 138 GLY B C   1 
ATOM   3386 O  O   . GLY B 1 138 ? 10.22322  4.52510   -12.81117 1.000 33.37435 ? 138 GLY B O   1 
ATOM   3387 N  N   . SER B 1 139 ? 8.38237   5.65119   -12.18331 1.000 27.76202 ? 139 SER B N   1 
ATOM   3388 C  CA  . SER B 1 139 ? 8.65220   6.83904   -12.98723 1.000 31.58212 ? 139 SER B CA  1 
ATOM   3389 C  C   . SER B 1 139 ? 8.42902   8.02163   -12.05610 1.000 34.63012 ? 139 SER B C   1 
ATOM   3390 O  O   . SER B 1 139 ? 7.28682   8.41385   -11.78811 1.000 30.54653 ? 139 SER B O   1 
ATOM   3391 C  CB  . SER B 1 139 ? 7.76378   6.91136   -14.22655 1.000 36.63075 ? 139 SER B CB  1 
ATOM   3392 O  OG  . SER B 1 139 ? 8.11899   8.02123   -15.04406 1.000 38.80870 ? 139 SER B OG  1 
ATOM   3393 N  N   . PHE B 1 140 ? 9.52558   8.56359   -11.54372 1.000 33.29204 ? 140 PHE B N   1 
ATOM   3394 C  CA  . PHE B 1 140 ? 9.48577   9.64085   -10.57088 1.000 36.23483 ? 140 PHE B CA  1 
ATOM   3395 C  C   . PHE B 1 140 ? 10.48969  10.71100  -10.97102 1.000 41.78328 ? 140 PHE B C   1 
ATOM   3396 O  O   . PHE B 1 140 ? 11.56357  10.40286  -11.49901 1.000 39.38185 ? 140 PHE B O   1 
ATOM   3397 C  CB  . PHE B 1 140 ? 9.79687   9.12702   -9.14963  1.000 33.48844 ? 140 PHE B CB  1 
ATOM   3398 C  CG  . PHE B 1 140 ? 8.72883   8.22808   -8.56938  1.000 30.28261 ? 140 PHE B CG  1 
ATOM   3399 C  CD1 . PHE B 1 140 ? 7.42392   8.66875   -8.44419  1.000 27.60923 ? 140 PHE B CD1 1 
ATOM   3400 C  CD2 . PHE B 1 140 ? 9.04255   6.95475   -8.12468  1.000 29.28130 ? 140 PHE B CD2 1 
ATOM   3401 C  CE1 . PHE B 1 140 ? 6.44892   7.85847   -7.89799  1.000 28.00515 ? 140 PHE B CE1 1 
ATOM   3402 C  CE2 . PHE B 1 140 ? 8.07150   6.13547   -7.57663  1.000 30.91027 ? 140 PHE B CE2 1 
ATOM   3403 C  CZ  . PHE B 1 140 ? 6.77034   6.59081   -7.45788  1.000 29.45910 ? 140 PHE B CZ  1 
ATOM   3404 N  N   . LEU B 1 141 ? 10.12143  11.96389  -10.74072 1.000 38.40027 ? 141 LEU B N   1 
ATOM   3405 C  CA  . LEU B 1 141 ? 11.01176  13.09670  -10.91125 1.000 41.71513 ? 141 LEU B CA  1 
ATOM   3406 C  C   . LEU B 1 141 ? 11.23552  13.73607  -9.54852  1.000 41.86102 ? 141 LEU B C   1 
ATOM   3407 O  O   . LEU B 1 141 ? 10.66739  13.30768  -8.54299  1.000 39.27435 ? 141 LEU B O   1 
ATOM   3408 C  CB  . LEU B 1 141 ? 10.43820  14.10746  -11.90990 1.000 40.88982 ? 141 LEU B CB  1 
ATOM   3409 C  CG  . LEU B 1 141 ? 10.21319  13.59279  -13.33395 1.000 43.86425 ? 141 LEU B CG  1 
ATOM   3410 C  CD1 . LEU B 1 141 ? 9.73036   14.71756  -14.24916 1.000 46.18802 ? 141 LEU B CD1 1 
ATOM   3411 C  CD2 . LEU B 1 141 ? 11.47865  12.94057  -13.88617 1.000 39.15609 ? 141 LEU B CD2 1 
ATOM   3412 N  N   . ASN B 1 142 ? 12.09427  14.75339  -9.51484  1.000 43.39980 ? 142 ASN B N   1 
ATOM   3413 C  CA  A ASN B 1 142 ? 12.26089  15.54359  -8.30589  0.500 43.90035 ? 142 ASN B CA  1 
ATOM   3414 C  CA  B ASN B 1 142 ? 12.25919  15.52636  -8.29376  0.500 43.89859 ? 142 ASN B CA  1 
ATOM   3415 C  C   . ASN B 1 142 ? 10.89993  16.02336  -7.82069  1.000 38.61987 ? 142 ASN B C   1 
ATOM   3416 O  O   . ASN B 1 142 ? 10.04315  16.40913  -8.62120  1.000 37.01339 ? 142 ASN B O   1 
ATOM   3417 C  CB  A ASN B 1 142 ? 13.18346  16.73558  -8.58010  0.500 44.09859 ? 142 ASN B CB  1 
ATOM   3418 C  CB  B ASN B 1 142 ? 13.21297  16.70676  -8.51539  0.500 44.10673 ? 142 ASN B CB  1 
ATOM   3419 C  CG  A ASN B 1 142 ? 14.45810  16.33467  -9.30472  0.500 46.91875 ? 142 ASN B CG  1 
ATOM   3420 C  CG  B ASN B 1 142 ? 13.67048  17.34198  -7.20758  0.500 45.25772 ? 142 ASN B CG  1 
ATOM   3421 O  OD1 A ASN B 1 142 ? 14.42521  15.94081  -10.47282 0.500 50.18873 ? 142 ASN B OD1 1 
ATOM   3422 O  OD1 B ASN B 1 142 ? 13.74820  16.67493  -6.17383  0.500 49.49701 ? 142 ASN B OD1 1 
ATOM   3423 N  ND2 A ASN B 1 142 ? 15.58978  16.44604  -8.61925  0.500 46.41657 ? 142 ASN B ND2 1 
ATOM   3424 N  ND2 B ASN B 1 142 ? 13.97506  18.63468  -7.24927  0.500 44.79713 ? 142 ASN B ND2 1 
ATOM   3425 N  N   . GLY B 1 143 ? 10.69458  15.98086  -6.50915  1.000 39.75949 ? 143 GLY B N   1 
ATOM   3426 C  CA  . GLY B 1 143 ? 9.43086   16.39809  -5.94058  1.000 33.92575 ? 143 GLY B CA  1 
ATOM   3427 C  C   . GLY B 1 143 ? 8.39147   15.30902  -5.79035  1.000 27.47304 ? 143 GLY B C   1 
ATOM   3428 O  O   . GLY B 1 143 ? 7.33311   15.57045  -5.21441  1.000 28.21530 ? 143 GLY B O   1 
ATOM   3429 N  N   . SER B 1 144 ? 8.65742   14.09913  -6.27948  1.000 28.15354 ? 144 SER B N   1 
ATOM   3430 C  CA  . SER B 1 144 ? 7.69897   13.00464  -6.17743  1.000 26.59653 ? 144 SER B CA  1 
ATOM   3431 C  C   . SER B 1 144 ? 7.72366   12.29188  -4.82709  1.000 24.73452 ? 144 SER B C   1 
ATOM   3432 O  O   . SER B 1 144 ? 6.84845   11.45535  -4.58524  1.000 20.88748 ? 144 SER B O   1 
ATOM   3433 C  CB  . SER B 1 144 ? 7.95553   11.97535  -7.27917  1.000 25.67638 ? 144 SER B CB  1 
ATOM   3434 O  OG  . SER B 1 144 ? 9.18386   11.31312  -7.04976  1.000 29.96003 ? 144 SER B OG  1 
ATOM   3435 N  N   . CYS B 1 145 ? 8.70250   12.57240  -3.96307  1.000 19.43727 ? 145 CYS B N   1 
ATOM   3436 C  CA  . CYS B 1 145 ? 8.74100   11.94099  -2.64576  1.000 19.55509 ? 145 CYS B CA  1 
ATOM   3437 C  C   . CYS B 1 145 ? 7.43788   12.17882  -1.89127  1.000 19.58006 ? 145 CYS B C   1 
ATOM   3438 O  O   . CYS B 1 145 ? 6.84041   13.25629  -1.96804  1.000 22.05152 ? 145 CYS B O   1 
ATOM   3439 C  CB  . CYS B 1 145 ? 9.92577   12.47047  -1.83261  1.000 20.70966 ? 145 CYS B CB  1 
ATOM   3440 S  SG  . CYS B 1 145 ? 11.54216  12.11624  -2.57301  1.000 29.27802 ? 145 CYS B SG  1 
ATOM   3441 N  N   . GLY B 1 146 ? 6.99257   11.15800  -1.15370  1.000 20.03785 ? 146 GLY B N   1 
ATOM   3442 C  CA  . GLY B 1 146 ? 5.70206   11.20459  -0.49785  1.000 19.05272 ? 146 GLY B CA  1 
ATOM   3443 C  C   . GLY B 1 146 ? 4.52598   10.68970  -1.32034  1.000 20.26471 ? 146 GLY B C   1 
ATOM   3444 O  O   . GLY B 1 146 ? 3.43597   10.50857  -0.75732  1.000 19.42698 ? 146 GLY B O   1 
ATOM   3445 N  N   . SER B 1 147 ? 4.69251   10.48864  -2.63322  1.000 19.86513 ? 147 SER B N   1 
ATOM   3446 C  CA  . SER B 1 147 ? 3.67366   9.79774   -3.42563  1.000 17.84205 ? 147 SER B CA  1 
ATOM   3447 C  C   . SER B 1 147 ? 3.45392   8.39790   -2.86013  1.000 20.09122 ? 147 SER B C   1 
ATOM   3448 O  O   . SER B 1 147 ? 4.36478   7.79025   -2.29383  1.000 17.72676 ? 147 SER B O   1 
ATOM   3449 C  CB  . SER B 1 147 ? 4.10037   9.69677   -4.89088  1.000 18.90465 ? 147 SER B CB  1 
ATOM   3450 O  OG  . SER B 1 147 ? 4.22142   10.96214  -5.52058  1.000 21.42055 ? 147 SER B OG  1 
ATOM   3451 N  N   . VAL B 1 148 ? 2.23831   7.87126   -3.01009  1.000 19.46277 ? 148 VAL B N   1 
ATOM   3452 C  CA  . VAL B 1 148 ? 1.91805   6.61317   -2.34640  1.000 17.88162 ? 148 VAL B CA  1 
ATOM   3453 C  C   . VAL B 1 148 ? 1.48764   5.55387   -3.35569  1.000 19.12651 ? 148 VAL B C   1 
ATOM   3454 O  O   . VAL B 1 148 ? 1.06197   5.84332   -4.47722  1.000 19.71148 ? 148 VAL B O   1 
ATOM   3455 C  CB  . VAL B 1 148 ? 0.84052   6.77371   -1.25495  1.000 20.60983 ? 148 VAL B CB  1 
ATOM   3456 C  CG1 . VAL B 1 148 ? 1.35101   7.67214   -0.11202  1.000 21.88715 ? 148 VAL B CG1 1 
ATOM   3457 C  CG2 . VAL B 1 148 ? -0.46124  7.29519   -1.84288  1.000 18.80279 ? 148 VAL B CG2 1 
ATOM   3458 N  N   . GLY B 1 149 ? 1.61698   4.30347   -2.92347  1.000 17.07634 ? 149 GLY B N   1 
ATOM   3459 C  CA  . GLY B 1 149 ? 1.10746   3.15667   -3.64449  1.000 16.02145 ? 149 GLY B CA  1 
ATOM   3460 C  C   . GLY B 1 149 ? -0.01494  2.52369   -2.84543  1.000 17.57266 ? 149 GLY B C   1 
ATOM   3461 O  O   . GLY B 1 149 ? -0.04080  2.60301   -1.61224  1.000 17.53364 ? 149 GLY B O   1 
ATOM   3462 N  N   . PHE B 1 150 ? -0.95078  1.89536   -3.54863  1.000 16.54484 ? 150 PHE B N   1 
ATOM   3463 C  CA  . PHE B 1 150 ? -2.14315  1.41436   -2.87338  1.000 18.02287 ? 150 PHE B CA  1 
ATOM   3464 C  C   . PHE B 1 150 ? -2.81592  0.33283   -3.70269  1.000 18.53603 ? 150 PHE B C   1 
ATOM   3465 O  O   . PHE B 1 150 ? -2.57869  0.19907   -4.90898  1.000 15.42057 ? 150 PHE B O   1 
ATOM   3466 C  CB  . PHE B 1 150 ? -3.13297  2.55588   -2.62022  1.000 16.56416 ? 150 PHE B CB  1 
ATOM   3467 C  CG  . PHE B 1 150 ? -3.63613  3.19680   -3.87719  1.000 16.27821 ? 150 PHE B CG  1 
ATOM   3468 C  CD1 . PHE B 1 150 ? -2.89268  4.17679   -4.51831  1.000 19.68958 ? 150 PHE B CD1 1 
ATOM   3469 C  CD2 . PHE B 1 150 ? -4.83490  2.80686   -4.43765  1.000 16.58174 ? 150 PHE B CD2 1 
ATOM   3470 C  CE1 . PHE B 1 150 ? -3.35018  4.75753   -5.69303  1.000 18.91536 ? 150 PHE B CE1 1 
ATOM   3471 C  CE2 . PHE B 1 150 ? -5.29188  3.38030   -5.61348  1.000 15.37594 ? 150 PHE B CE2 1 
ATOM   3472 C  CZ  . PHE B 1 150 ? -4.55953  4.35898   -6.23246  1.000 18.55948 ? 150 PHE B CZ  1 
ATOM   3473 N  N   . ASN B 1 151 ? -3.66333  -0.43675  -3.02358  1.000 16.93710 ? 151 ASN B N   1 
ATOM   3474 C  CA  . ASN B 1 151 ? -4.63106  -1.32144  -3.64874  1.000 21.46924 ? 151 ASN B CA  1 
ATOM   3475 C  C   . ASN B 1 151 ? -6.00855  -0.93391  -3.13819  1.000 22.92600 ? 151 ASN B C   1 
ATOM   3476 O  O   . ASN B 1 151 ? -6.14143  -0.27389  -2.10100  1.000 20.35624 ? 151 ASN B O   1 
ATOM   3477 C  CB  . ASN B 1 151 ? -4.36428  -2.79786  -3.32297  1.000 23.67795 ? 151 ASN B CB  1 
ATOM   3478 C  CG  . ASN B 1 151 ? -3.09683  -3.31828  -3.96770  1.000 27.10015 ? 151 ASN B CG  1 
ATOM   3479 O  OD1 . ASN B 1 151 ? -3.11086  -3.76810  -5.10971  1.000 28.45875 ? 151 ASN B OD1 1 
ATOM   3480 N  ND2 . ASN B 1 151 ? -1.99556  -3.25588  -3.23840  1.000 22.91136 ? 151 ASN B ND2 1 
ATOM   3481 N  N   . ILE B 1 152 ? -7.03638  -1.36002  -3.86163  1.000 22.05902 ? 152 ILE B N   1 
ATOM   3482 C  CA  . ILE B 1 152 ? -8.41446  -1.14094  -3.44733  1.000 26.75930 ? 152 ILE B CA  1 
ATOM   3483 C  C   . ILE B 1 152 ? -9.11373  -2.48973  -3.36948  1.000 31.94669 ? 152 ILE B C   1 
ATOM   3484 O  O   . ILE B 1 152 ? -9.01122  -3.30838  -4.29132  1.000 32.63223 ? 152 ILE B O   1 
ATOM   3485 C  CB  . ILE B 1 152 ? -9.15848  -0.18767  -4.39595  1.000 24.91367 ? 152 ILE B CB  1 
ATOM   3486 C  CG1 . ILE B 1 152 ? -8.44194  1.16129   -4.45387  1.000 24.37921 ? 152 ILE B CG1 1 
ATOM   3487 C  CG2 . ILE B 1 152 ? -10.60979 -0.00783  -3.93025  1.000 31.23761 ? 152 ILE B CG2 1 
ATOM   3488 C  CD1 . ILE B 1 152 ? -9.20559  2.22404   -5.20015  1.000 30.91788 ? 152 ILE B CD1 1 
ATOM   3489 N  N   . ASP B 1 153 ? -9.80110  -2.72327  -2.25935  1.000 30.54767 ? 153 ASP B N   1 
ATOM   3490 C  CA  . ASP B 1 153 ? -10.61123 -3.91892  -2.05656  1.000 37.37308 ? 153 ASP B CA  1 
ATOM   3491 C  C   . ASP B 1 153 ? -11.99790 -3.44757  -1.64927  1.000 41.30003 ? 153 ASP B C   1 
ATOM   3492 O  O   . ASP B 1 153 ? -12.17474 -2.92789  -0.54053  1.000 43.51155 ? 153 ASP B O   1 
ATOM   3493 C  CB  . ASP B 1 153 ? -9.98923  -4.82714  -0.99881  1.000 40.55425 ? 153 ASP B CB  1 
ATOM   3494 C  CG  . ASP B 1 153 ? -8.62889  -5.34844  -1.41824  1.000 51.55940 ? 153 ASP B CG  1 
ATOM   3495 O  OD1 . ASP B 1 153 ? -8.58847  -6.23704  -2.30424  1.000 52.85893 ? 153 ASP B OD1 1 
ATOM   3496 O  OD2 . ASP B 1 153 ? -7.59954  -4.84962  -0.89167  1.000 48.30577 ? 153 ASP B OD2 1 
ATOM   3497 N  N   . TYR B 1 154 ? -12.96644 -3.61526  -2.55451  1.000 42.07115 ? 154 TYR B N   1 
ATOM   3498 C  CA  . TYR B 1 154 ? -14.31783 -3.07904  -2.41104  1.000 42.78210 ? 154 TYR B CA  1 
ATOM   3499 C  C   . TYR B 1 154 ? -14.27364 -1.55822  -2.33249  1.000 42.62695 ? 154 TYR B C   1 
ATOM   3500 O  O   . TYR B 1 154 ? -14.00114 -0.89118  -3.33636  1.000 38.49472 ? 154 TYR B O   1 
ATOM   3501 C  CB  . TYR B 1 154 ? -15.01537 -3.68556  -1.18925  1.000 50.32284 ? 154 TYR B CB  1 
ATOM   3502 C  CG  . TYR B 1 154 ? -14.94762 -5.19455  -1.19288  1.000 59.63061 ? 154 TYR B CG  1 
ATOM   3503 C  CD1 . TYR B 1 154 ? -15.79506 -5.94558  -2.00061  1.000 63.12056 ? 154 TYR B CD1 1 
ATOM   3504 C  CD2 . TYR B 1 154 ? -14.01335 -5.86933  -0.41442  1.000 64.01863 ? 154 TYR B CD2 1 
ATOM   3505 C  CE1 . TYR B 1 154 ? -15.72441 -7.32989  -2.02170  1.000 70.71995 ? 154 TYR B CE1 1 
ATOM   3506 C  CE2 . TYR B 1 154 ? -13.93458 -7.25232  -0.42799  1.000 73.96114 ? 154 TYR B CE2 1 
ATOM   3507 C  CZ  . TYR B 1 154 ? -14.79337 -7.97856  -1.23336  1.000 77.15143 ? 154 TYR B CZ  1 
ATOM   3508 O  OH  . TYR B 1 154 ? -14.71755 -9.35548  -1.24679  1.000 76.79049 ? 154 TYR B OH  1 
ATOM   3509 N  N   . ASP B 1 155 ? -14.53504 -0.99931  -1.15179  1.000 37.71075 ? 155 ASP B N   1 
ATOM   3510 C  CA  . ASP B 1 155 ? -14.46190 0.43964   -0.94186  1.000 37.17388 ? 155 ASP B CA  1 
ATOM   3511 C  C   . ASP B 1 155 ? -13.31980 0.83619   -0.00771  1.000 37.39619 ? 155 ASP B C   1 
ATOM   3512 O  O   . ASP B 1 155 ? -13.28795 1.97661   0.47372   1.000 33.37964 ? 155 ASP B O   1 
ATOM   3513 C  CB  . ASP B 1 155 ? -15.79646 0.95808   -0.39746  1.000 38.89743 ? 155 ASP B CB  1 
ATOM   3514 C  CG  . ASP B 1 155 ? -16.17118 0.32206   0.93565   1.000 45.54022 ? 155 ASP B CG  1 
ATOM   3515 O  OD1 . ASP B 1 155 ? -15.59246 -0.73431  1.27782   1.000 42.69558 ? 155 ASP B OD1 1 
ATOM   3516 O  OD2 . ASP B 1 155 ? -17.05138 0.87306   1.63733   1.000 45.77549 ? 155 ASP B OD2 1 
ATOM   3517 N  N   . CYS B 1 156 ? -12.37914 -0.06645  0.25465   1.000 30.41735 ? 156 CYS B N   1 
ATOM   3518 C  CA  . CYS B 1 156 ? -11.31593 0.17678   1.21956   1.000 26.91742 ? 156 CYS B CA  1 
ATOM   3519 C  C   . CYS B 1 156 ? -9.97630  0.32837   0.50572   1.000 26.56971 ? 156 CYS B C   1 
ATOM   3520 O  O   . CYS B 1 156 ? -9.58405  -0.54366  -0.27720  1.000 24.50790 ? 156 CYS B O   1 
ATOM   3521 C  CB  . CYS B 1 156 ? -11.24935 -0.95725  2.24466   1.000 25.80805 ? 156 CYS B CB  1 
ATOM   3522 S  SG  . CYS B 1 156 ? -10.01743 -0.67830  3.51739   1.000 29.63123 ? 156 CYS B SG  1 
ATOM   3523 N  N   . VAL B 1 157 ? -9.28777  1.43467   0.78048   1.000 21.18283 ? 157 VAL B N   1 
ATOM   3524 C  CA  . VAL B 1 157 ? -7.94784  1.68444   0.25682   1.000 21.95105 ? 157 VAL B CA  1 
ATOM   3525 C  C   . VAL B 1 157 ? -6.91220  1.04562   1.17740   1.000 21.51812 ? 157 VAL B C   1 
ATOM   3526 O  O   . VAL B 1 157 ? -6.79561  1.40794   2.35223   1.000 19.20742 ? 157 VAL B O   1 
ATOM   3527 C  CB  . VAL B 1 157 ? -7.67647  3.19056   0.12596   1.000 18.34776 ? 157 VAL B CB  1 
ATOM   3528 C  CG1 . VAL B 1 157 ? -6.27519  3.41077   -0.42873  1.000 18.60970 ? 157 VAL B CG1 1 
ATOM   3529 C  CG2 . VAL B 1 157 ? -8.72311  3.85764   -0.73990  1.000 23.66324 ? 157 VAL B CG2 1 
ATOM   3530 N  N   . SER B 1 158 ? -6.12035  0.13990   0.63906   1.000 21.33815 ? 158 SER B N   1 
ATOM   3531 C  CA  . SER B 1 158 ? -4.99108  -0.42038  1.37521   1.000 20.66573 ? 158 SER B CA  1 
ATOM   3532 C  C   . SER B 1 158 ? -3.72716  0.28727   0.90570   1.000 18.33862 ? 158 SER B C   1 
ATOM   3533 O  O   . SER B 1 158 ? -3.19569  -0.01608  -0.16619  1.000 17.62383 ? 158 SER B O   1 
ATOM   3534 C  CB  . SER B 1 158 ? -4.91418  -1.92993  1.18037   1.000 21.47626 ? 158 SER B CB  1 
ATOM   3535 O  OG  . SER B 1 158 ? -5.96965  -2.54851  1.90216   1.000 23.68378 ? 158 SER B OG  1 
ATOM   3536 N  N   . PHE B 1 159 ? -3.25459  1.24157   1.71063   1.000 18.03428 ? 159 PHE B N   1 
ATOM   3537 C  CA  . PHE B 1 159 ? -2.00504  1.95022   1.43021   1.000 15.93005 ? 159 PHE B CA  1 
ATOM   3538 C  C   . PHE B 1 159 ? -0.82838  1.05350   1.79035   1.000 18.17150 ? 159 PHE B C   1 
ATOM   3539 O  O   . PHE B 1 159 ? -0.72868  0.60012   2.93508   1.000 18.50129 ? 159 PHE B O   1 
ATOM   3540 C  CB  . PHE B 1 159 ? -1.91161  3.24595   2.23733   1.000 15.72365 ? 159 PHE B CB  1 
ATOM   3541 C  CG  . PHE B 1 159 ? -2.94520  4.28908   1.87723   1.000 16.56291 ? 159 PHE B CG  1 
ATOM   3542 C  CD1 . PHE B 1 159 ? -2.80802  5.04966   0.73104   1.000 14.57930 ? 159 PHE B CD1 1 
ATOM   3543 C  CD2 . PHE B 1 159 ? -4.01210  4.54906   2.72606   1.000 19.54331 ? 159 PHE B CD2 1 
ATOM   3544 C  CE1 . PHE B 1 159 ? -3.72809  6.03955   0.40957   1.000 15.49172 ? 159 PHE B CE1 1 
ATOM   3545 C  CE2 . PHE B 1 159 ? -4.95408  5.52731   2.40879   1.000 19.22306 ? 159 PHE B CE2 1 
ATOM   3546 C  CZ  . PHE B 1 159 ? -4.81260  6.27047   1.24960   1.000 17.82547 ? 159 PHE B CZ  1 
ATOM   3547 N  N   . CYS B 1 160 ? 0.07783   0.82109   0.82966   1.000 17.60439 ? 160 CYS B N   1 
ATOM   3548 C  CA  . CYS B 1 160 ? 1.18313   -0.10363  1.03335   1.000 14.99026 ? 160 CYS B CA  1 
ATOM   3549 C  C   . CYS B 1 160 ? 2.55890   0.51109   0.84450   1.000 19.04018 ? 160 CYS B C   1 
ATOM   3550 O  O   . CYS B 1 160 ? 3.55042   -0.12262  1.23168   1.000 23.32122 ? 160 CYS B O   1 
ATOM   3551 C  CB  . CYS B 1 160 ? 1.05229   -1.31582  0.09192   1.000 17.06636 ? 160 CYS B CB  1 
ATOM   3552 S  SG  . CYS B 1 160 ? 1.01408   -0.93026  -1.68252  1.000 19.99924 ? 160 CYS B SG  1 
ATOM   3553 N  N   . TYR B 1 161 ? 2.66256   1.70091   0.25253   1.000 15.91835 ? 161 TYR B N   1 
ATOM   3554 C  CA  . TYR B 1 161 ? 3.96130   2.20987   -0.16402  1.000 16.16480 ? 161 TYR B CA  1 
ATOM   3555 C  C   . TYR B 1 161 ? 3.98006   3.72438   -0.07570  1.000 17.66256 ? 161 TYR B C   1 
ATOM   3556 O  O   . TYR B 1 161 ? 2.99616   4.37915   -0.41601  1.000 16.97447 ? 161 TYR B O   1 
ATOM   3557 C  CB  . TYR B 1 161 ? 4.29807   1.77469   -1.60229  1.000 16.90734 ? 161 TYR B CB  1 
ATOM   3558 C  CG  . TYR B 1 161 ? 5.62531   2.27467   -2.11854  1.000 20.42207 ? 161 TYR B CG  1 
ATOM   3559 C  CD1 . TYR B 1 161 ? 6.81127   1.62078   -1.79222  1.000 17.41448 ? 161 TYR B CD1 1 
ATOM   3560 C  CD2 . TYR B 1 161 ? 5.69942   3.40015   -2.93927  1.000 17.53271 ? 161 TYR B CD2 1 
ATOM   3561 C  CE1 . TYR B 1 161 ? 8.03657   2.07793   -2.27115  1.000 19.36196 ? 161 TYR B CE1 1 
ATOM   3562 C  CE2 . TYR B 1 161 ? 6.91881   3.86146   -3.41762  1.000 18.26829 ? 161 TYR B CE2 1 
ATOM   3563 C  CZ  . TYR B 1 161 ? 8.08397   3.19750   -3.08345  1.000 17.12654 ? 161 TYR B CZ  1 
ATOM   3564 O  OH  . TYR B 1 161 ? 9.29845   3.66407   -3.55896  1.000 18.17296 ? 161 TYR B OH  1 
ATOM   3565 N  N   . MET B 1 162 ? 5.11024   4.27155   0.37008   1.000 17.74202 ? 162 MET B N   1 
ATOM   3566 C  CA  . MET B 1 162 ? 5.37375   5.69916   0.28821   1.000 16.80870 ? 162 MET B CA  1 
ATOM   3567 C  C   . MET B 1 162 ? 6.75826   5.88462   -0.30310  1.000 19.19856 ? 162 MET B C   1 
ATOM   3568 O  O   . MET B 1 162 ? 7.71926   5.25173   0.14927   1.000 18.39205 ? 162 MET B O   1 
ATOM   3569 C  CB  . MET B 1 162 ? 5.28241   6.39133   1.65388   1.000 19.85046 ? 162 MET B CB  1 
ATOM   3570 C  CG  . MET B 1 162 ? 5.65258   7.87204   1.58473   1.000 21.22107 ? 162 MET B CG  1 
ATOM   3571 S  SD  . MET B 1 162 ? 5.35342   8.83008   3.08882   1.000 25.68596 ? 162 MET B SD  1 
ATOM   3572 C  CE  . MET B 1 162 ? 3.57643   9.12656   2.96007   1.000 21.95102 ? 162 MET B CE  1 
ATOM   3573 N  N   . HIS B 1 163 ? 6.85295   6.73571   -1.31919  1.000 18.62460 ? 163 HIS B N   1 
ATOM   3574 C  CA  . HIS B 1 163 ? 8.09780   6.88943   -2.05343  1.000 19.36909 ? 163 HIS B CA  1 
ATOM   3575 C  C   . HIS B 1 163 ? 9.07401   7.78164   -1.29455  1.000 18.79633 ? 163 HIS B C   1 
ATOM   3576 O  O   . HIS B 1 163 ? 8.70116   8.86508   -0.83924  1.000 20.38419 ? 163 HIS B O   1 
ATOM   3577 C  CB  . HIS B 1 163 ? 7.83776   7.47291   -3.43940  1.000 17.06248 ? 163 HIS B CB  1 
ATOM   3578 C  CG  . HIS B 1 163 ? 9.07734   7.59121   -4.25479  1.000 16.86601 ? 163 HIS B CG  1 
ATOM   3579 N  ND1 . HIS B 1 163 ? 9.92732   6.52450   -4.45078  1.000 18.62328 ? 163 HIS B ND1 1 
ATOM   3580 C  CD2 . HIS B 1 163 ? 9.63698   8.64567   -4.89138  1.000 20.04797 ? 163 HIS B CD2 1 
ATOM   3581 C  CE1 . HIS B 1 163 ? 10.95767  6.91624   -5.17853  1.000 20.11162 ? 163 HIS B CE1 1 
ATOM   3582 N  NE2 . HIS B 1 163 ? 10.80376  8.19798   -5.46189  1.000 21.00045 ? 163 HIS B NE2 1 
ATOM   3583 N  N   . HIS B 1 164 ? 10.33948  7.35075   -1.21869  1.000 17.78211 ? 164 HIS B N   1 
ATOM   3584 C  CA  . HIS B 1 164 ? 11.37965  8.05387   -0.47402  1.000 20.26185 ? 164 HIS B CA  1 
ATOM   3585 C  C   . HIS B 1 164 ? 12.55517  8.48498   -1.34165  1.000 25.17712 ? 164 HIS B C   1 
ATOM   3586 O  O   . HIS B 1 164 ? 13.00342  9.62893   -1.23390  1.000 24.69435 ? 164 HIS B O   1 
ATOM   3587 C  CB  . HIS B 1 164 ? 11.89412  7.16459   0.67152   1.000 17.92779 ? 164 HIS B CB  1 
ATOM   3588 C  CG  . HIS B 1 164 ? 11.08287  7.24819   1.92904   1.000 20.23659 ? 164 HIS B CG  1 
ATOM   3589 N  ND1 . HIS B 1 164 ? 9.81977   6.70439   2.04629   1.000 22.92506 ? 164 HIS B ND1 1 
ATOM   3590 C  CD2 . HIS B 1 164 ? 11.36882  7.79155   3.13490   1.000 21.10025 ? 164 HIS B CD2 1 
ATOM   3591 C  CE1 . HIS B 1 164 ? 9.36009   6.92042   3.26620   1.000 20.53610 ? 164 HIS B CE1 1 
ATOM   3592 N  NE2 . HIS B 1 164 ? 10.28169  7.58067   3.94604   1.000 24.29005 ? 164 HIS B NE2 1 
ATOM   3593 N  N   . MET B 1 165 ? 13.07986  7.60886   -2.20114  1.000 22.42726 ? 165 MET B N   1 
ATOM   3594 C  CA  . MET B 1 165 ? 14.33410  7.91481   -2.87734  1.000 25.82212 ? 165 MET B CA  1 
ATOM   3595 C  C   . MET B 1 165 ? 14.44674  7.17830   -4.20421  1.000 26.58901 ? 165 MET B C   1 
ATOM   3596 O  O   . MET B 1 165 ? 13.78615  6.16306   -4.44243  1.000 21.37808 ? 165 MET B O   1 
ATOM   3597 C  CB  . MET B 1 165 ? 15.53047  7.54833   -2.00602  1.000 21.99992 ? 165 MET B CB  1 
ATOM   3598 C  CG  . MET B 1 165 ? 15.49422  6.11663   -1.53804  1.000 26.97410 ? 165 MET B CG  1 
ATOM   3599 S  SD  . MET B 1 165 ? 16.70739  5.80794   -0.24822  1.000 40.66016 ? 165 MET B SD  1 
ATOM   3600 C  CE  . MET B 1 165 ? 16.73833  7.42815   0.51535   1.000 32.20414 ? 165 MET B CE  1 
ATOM   3601 N  N   . GLU B 1 166 ? 15.32860  7.69551   -5.05575  1.000 23.50852 ? 166 GLU B N   1 
ATOM   3602 C  CA  . GLU B 1 166 ? 15.75456  7.01329   -6.26684  1.000 29.11630 ? 166 GLU B CA  1 
ATOM   3603 C  C   . GLU B 1 166 ? 17.16631  6.49051   -6.06185  1.000 32.55944 ? 166 GLU B C   1 
ATOM   3604 O  O   . GLU B 1 166 ? 18.02643  7.21088   -5.54250  1.000 35.66608 ? 166 GLU B O   1 
ATOM   3605 C  CB  . GLU B 1 166 ? 15.70915  7.94626   -7.47662  1.000 29.33974 ? 166 GLU B CB  1 
ATOM   3606 C  CG  . GLU B 1 166 ? 16.27726  7.30325   -8.73189  1.000 35.26065 ? 166 GLU B CG  1 
ATOM   3607 C  CD  . GLU B 1 166 ? 16.10478  8.16285   -9.96378  1.000 37.21721 ? 166 GLU B CD  1 
ATOM   3608 O  OE1 . GLU B 1 166 ? 14.94829  8.49161   -10.30613 1.000 43.21133 ? 166 GLU B OE1 1 
ATOM   3609 O  OE2 . GLU B 1 166 ? 17.12711  8.50478   -10.58866 1.000 41.09365 ? 166 GLU B OE2 1 
ATOM   3610 N  N   . LEU B 1 167 ? 17.40079  5.24501   -6.46131  1.000 30.69529 ? 167 LEU B N   1 
ATOM   3611 C  CA  . LEU B 1 167 ? 18.71591  4.63334   -6.32722  1.000 30.95524 ? 167 LEU B CA  1 
ATOM   3612 C  C   . LEU B 1 167 ? 19.56039  4.89799   -7.57119  1.000 37.95310 ? 167 LEU B C   1 
ATOM   3613 O  O   . LEU B 1 167 ? 19.02627  5.21149   -8.64354  1.000 34.14605 ? 167 LEU B O   1 
ATOM   3614 C  CB  . LEU B 1 167 ? 18.56653  3.13306   -6.08280  1.000 31.53464 ? 167 LEU B CB  1 
ATOM   3615 C  CG  . LEU B 1 167 ? 17.93763  2.76158   -4.73548  1.000 32.25480 ? 167 LEU B CG  1 
ATOM   3616 C  CD1 . LEU B 1 167 ? 17.73903  1.25672   -4.62433  1.000 28.28923 ? 167 LEU B CD1 1 
ATOM   3617 C  CD2 . LEU B 1 167 ? 18.77530  3.28328   -3.57541  1.000 32.15729 ? 167 LEU B CD2 1 
ATOM   3618 N  N   . PRO B 1 168 ? 20.89327  4.79100   -7.46159  1.000 39.52896 ? 168 PRO B N   1 
ATOM   3619 C  CA  . PRO B 1 168 ? 21.75073  5.16007   -8.60343  1.000 34.10015 ? 168 PRO B CA  1 
ATOM   3620 C  C   . PRO B 1 168 ? 21.41081  4.43709   -9.89138  1.000 37.80639 ? 168 PRO B C   1 
ATOM   3621 O  O   . PRO B 1 168 ? 21.65757  4.97981   -10.97466 1.000 40.41896 ? 168 PRO B O   1 
ATOM   3622 C  CB  . PRO B 1 168 ? 23.15911  4.79754   -8.11389  1.000 36.69120 ? 168 PRO B CB  1 
ATOM   3623 C  CG  . PRO B 1 168 ? 23.07315  4.90062   -6.63701  1.000 41.23541 ? 168 PRO B CG  1 
ATOM   3624 C  CD  . PRO B 1 168 ? 21.69061  4.43418   -6.27488  1.000 35.70639 ? 168 PRO B CD  1 
ATOM   3625 N  N   . THR B 1 169 ? 20.84615  3.23642   -9.81969  1.000 38.44955 ? 169 THR B N   1 
ATOM   3626 C  CA  . THR B 1 169 ? 20.47746  2.53273   -11.04040 1.000 36.49745 ? 169 THR B CA  1 
ATOM   3627 C  C   . THR B 1 169 ? 19.19062  3.05467   -11.66463 1.000 35.77108 ? 169 THR B C   1 
ATOM   3628 O  O   . THR B 1 169 ? 18.79048  2.55544   -12.72185 1.000 38.24799 ? 169 THR B O   1 
ATOM   3629 C  CB  . THR B 1 169 ? 20.34085  1.03605   -10.76728 1.000 37.17565 ? 169 THR B CB  1 
ATOM   3630 O  OG1 . THR B 1 169 ? 19.42056  0.82818   -9.68922  1.000 33.80324 ? 169 THR B OG1 1 
ATOM   3631 C  CG2 . THR B 1 169 ? 21.69874  0.44127   -10.40541 1.000 38.28640 ? 169 THR B CG2 1 
ATOM   3632 N  N   . GLY B 1 170 ? 18.53416  4.03639   -11.04817 1.000 35.88405 ? 170 GLY B N   1 
ATOM   3633 C  CA  . GLY B 1 170 ? 17.29165  4.57137   -11.56925 1.000 31.35089 ? 170 GLY B CA  1 
ATOM   3634 C  C   . GLY B 1 170 ? 16.02159  3.92753   -11.04600 1.000 32.09932 ? 170 GLY B C   1 
ATOM   3635 O  O   . GLY B 1 170 ? 14.92895  4.37956   -11.41037 1.000 35.31974 ? 170 GLY B O   1 
ATOM   3636 N  N   . VAL B 1 171 ? 16.12243  2.88206   -10.22138 1.000 31.49142 ? 171 VAL B N   1 
ATOM   3637 C  CA  . VAL B 1 171 ? 14.95391  2.26608   -9.59691  1.000 27.72325 ? 171 VAL B CA  1 
ATOM   3638 C  C   . VAL B 1 171 ? 14.68110  2.97947   -8.28068  1.000 28.50506 ? 171 VAL B C   1 
ATOM   3639 O  O   . VAL B 1 171 ? 15.44101  3.86970   -7.88269  1.000 29.31655 ? 171 VAL B O   1 
ATOM   3640 C  CB  . VAL B 1 171 ? 15.15301  0.75671   -9.37367  1.000 30.51119 ? 171 VAL B CB  1 
ATOM   3641 C  CG1 . VAL B 1 171 ? 15.42968  0.05524   -10.69973 1.000 28.46389 ? 171 VAL B CG1 1 
ATOM   3642 C  CG2 . VAL B 1 171 ? 16.27392  0.51303   -8.36521  1.000 22.32059 ? 171 VAL B CG2 1 
ATOM   3643 N  N   . HIS B 1 172 ? 13.60758  2.59247   -7.58743  1.000 25.14823 ? 172 HIS B N   1 
ATOM   3644 C  CA  . HIS B 1 172 ? 13.07227  3.40930   -6.50912  1.000 25.34072 ? 172 HIS B CA  1 
ATOM   3645 C  C   . HIS B 1 172 ? 12.87870  2.59980   -5.23285  1.000 23.74856 ? 172 HIS B C   1 
ATOM   3646 O  O   . HIS B 1 172 ? 12.62478  1.39060   -5.26251  1.000 20.94195 ? 172 HIS B O   1 
ATOM   3647 C  CB  . HIS B 1 172 ? 11.76127  4.06812   -6.94722  1.000 21.95567 ? 172 HIS B CB  1 
ATOM   3648 C  CG  . HIS B 1 172 ? 11.92332  4.93856   -8.15379  1.000 30.78424 ? 172 HIS B CG  1 
ATOM   3649 N  ND1 . HIS B 1 172 ? 11.51858  4.55374   -9.41470  1.000 27.43076 ? 172 HIS B ND1 1 
ATOM   3650 C  CD2 . HIS B 1 172 ? 12.50207  6.15446   -8.30032  1.000 30.49668 ? 172 HIS B CD2 1 
ATOM   3651 C  CE1 . HIS B 1 172 ? 11.81565  5.50657   -10.28046 1.000 31.01567 ? 172 HIS B CE1 1 
ATOM   3652 N  NE2 . HIS B 1 172 ? 12.41673  6.48702   -9.63111  1.000 30.61547 ? 172 HIS B NE2 1 
ATOM   3653 N  N   . ALA B 1 173 ? 13.01300  3.29569   -4.10355  1.000 19.76068 ? 173 ALA B N   1 
ATOM   3654 C  CA  . ALA B 1 173 ? 12.94459  2.69205   -2.78713  1.000 20.30739 ? 173 ALA B CA  1 
ATOM   3655 C  C   . ALA B 1 173 ? 12.05836  3.54802   -1.89911  1.000 19.94525 ? 173 ALA B C   1 
ATOM   3656 O  O   . ALA B 1 173 ? 12.04480  4.77976   -2.01879  1.000 16.68689 ? 173 ALA B O   1 
ATOM   3657 C  CB  . ALA B 1 173 ? 14.34377  2.54114   -2.16486  1.000 20.76893 ? 173 ALA B CB  1 
ATOM   3658 N  N   . GLY B 1 174 ? 11.31038  2.88155   -1.02626  1.000 20.52294 ? 174 GLY B N   1 
ATOM   3659 C  CA  . GLY B 1 174 ? 10.39959  3.55209   -0.12772  1.000 20.24684 ? 174 GLY B CA  1 
ATOM   3660 C  C   . GLY B 1 174 ? 10.02446  2.64674   1.02313   1.000 19.24513 ? 174 GLY B C   1 
ATOM   3661 O  O   . GLY B 1 174 ? 10.61769  1.58545   1.22179   1.000 16.23430 ? 174 GLY B O   1 
ATOM   3662 N  N   . THR B 1 175 ? 9.01447   3.07478   1.77242   1.000 19.04549 ? 175 THR B N   1 
ATOM   3663 C  CA  . THR B 1 175 ? 8.59237   2.41574   2.99888   1.000 16.48841 ? 175 THR B CA  1 
ATOM   3664 C  C   . THR B 1 175 ? 7.11451   2.06690   2.91760   1.000 18.25959 ? 175 THR B C   1 
ATOM   3665 O  O   . THR B 1 175 ? 6.40088   2.50383   2.01239   1.000 16.82623 ? 175 THR B O   1 
ATOM   3666 C  CB  . THR B 1 175 ? 8.81975   3.31525   4.22245   1.000 19.06896 ? 175 THR B CB  1 
ATOM   3667 O  OG1 . THR B 1 175 ? 7.91913   4.43725   4.16064   1.000 16.83929 ? 175 THR B OG1 1 
ATOM   3668 C  CG2 . THR B 1 175 ? 10.25807  3.80947   4.25686   1.000 16.79738 ? 175 THR B CG2 1 
ATOM   3669 N  N   . ASP B 1 176 ? 6.64947   1.29015   3.89928   1.000 15.13870 ? 176 ASP B N   1 
ATOM   3670 C  CA  . ASP B 1 176 ? 5.21649   1.21009   4.11555   1.000 19.06798 ? 176 ASP B CA  1 
ATOM   3671 C  C   . ASP B 1 176 ? 4.77388   2.47758   4.83933   1.000 16.58683 ? 176 ASP B C   1 
ATOM   3672 O  O   . ASP B 1 176 ? 5.57960   3.36464   5.14346   1.000 14.81989 ? 176 ASP B O   1 
ATOM   3673 C  CB  . ASP B 1 176 ? 4.83890   -0.06419  4.87936   1.000 17.80079 ? 176 ASP B CB  1 
ATOM   3674 C  CG  . ASP B 1 176 ? 5.47714   -0.14405  6.26984   1.000 20.17668 ? 176 ASP B CG  1 
ATOM   3675 O  OD1 . ASP B 1 176 ? 5.72347   0.90845   6.90468   1.000 19.17640 ? 176 ASP B OD1 1 
ATOM   3676 O  OD2 . ASP B 1 176 ? 5.74710   -1.27800  6.71959   1.000 20.02556 ? 176 ASP B OD2 1 
ATOM   3677 N  N   . LEU B 1 177 ? 3.48522   2.56182   5.14204   1.000 18.00237 ? 177 LEU B N   1 
ATOM   3678 C  CA  . LEU B 1 177 ? 2.95361   3.77989   5.73688   1.000 17.25308 ? 177 LEU B CA  1 
ATOM   3679 C  C   . LEU B 1 177 ? 3.23756   3.88171   7.22716   1.000 19.49818 ? 177 LEU B C   1 
ATOM   3680 O  O   . LEU B 1 177 ? 2.91753   4.91383   7.82315   1.000 20.56834 ? 177 LEU B O   1 
ATOM   3681 C  CB  . LEU B 1 177 ? 1.44939   3.89074   5.46935   1.000 17.73092 ? 177 LEU B CB  1 
ATOM   3682 C  CG  . LEU B 1 177 ? 1.12595   4.75571   4.25554   1.000 19.51550 ? 177 LEU B CG  1 
ATOM   3683 C  CD1 . LEU B 1 177 ? 1.55627   6.20358   4.47692   1.000 19.32250 ? 177 LEU B CD1 1 
ATOM   3684 C  CD2 . LEU B 1 177 ? 1.78330   4.19091   2.97962   1.000 17.75832 ? 177 LEU B CD2 1 
ATOM   3685 N  N   . GLU B 1 178 ? 3.83085   2.84907   7.83347   1.000 17.31020 ? 178 GLU B N   1 
ATOM   3686 C  CA  . GLU B 1 178 ? 4.35103   2.92159   9.18947   1.000 21.20514 ? 178 GLU B CA  1 
ATOM   3687 C  C   . GLU B 1 178 ? 5.84975   3.17921   9.19882   1.000 19.08178 ? 178 GLU B C   1 
ATOM   3688 O  O   . GLU B 1 178 ? 6.48827   3.01801   10.23799  1.000 20.83155 ? 178 GLU B O   1 
ATOM   3689 C  CB  . GLU B 1 178 ? 4.01383   1.64139   9.95663   1.000 19.82899 ? 178 GLU B CB  1 
ATOM   3690 C  CG  . GLU B 1 178 ? 2.50532   1.47945   10.15797  1.000 25.26428 ? 178 GLU B CG  1 
ATOM   3691 C  CD  . GLU B 1 178 ? 2.10633   0.13337   10.72560  1.000 33.86203 ? 178 GLU B CD  1 
ATOM   3692 O  OE1 . GLU B 1 178 ? 2.83907   -0.41266  11.56801  1.000 32.02563 ? 178 GLU B OE1 1 
ATOM   3693 O  OE2 . GLU B 1 178 ? 1.04469   -0.38488  10.32511  1.000 43.40295 ? 178 GLU B OE2 1 
ATOM   3694 N  N   . GLY B 1 179 ? 6.41837   3.54457   8.05085   1.000 18.41466 ? 179 GLY B N   1 
ATOM   3695 C  CA  . GLY B 1 179 ? 7.79671   3.99764   7.95837   1.000 17.63770 ? 179 GLY B CA  1 
ATOM   3696 C  C   . GLY B 1 179 ? 8.86015   2.92250   7.89261   1.000 18.35622 ? 179 GLY B C   1 
ATOM   3697 O  O   . GLY B 1 179 ? 10.04881  3.25023   8.00000   1.000 21.06879 ? 179 GLY B O   1 
ATOM   3698 N  N   . ASN B 1 180 ? 8.49120   1.65655   7.73190   1.000 17.58817 ? 180 ASN B N   1 
ATOM   3699 C  CA  . ASN B 1 180 ? 9.47728   0.58301   7.62677   1.000 17.73184 ? 180 ASN B CA  1 
ATOM   3700 C  C   . ASN B 1 180 ? 9.91324   0.44308   6.17653   1.000 19.50080 ? 180 ASN B C   1 
ATOM   3701 O  O   . ASN B 1 180 ? 9.07148   0.29365   5.28293   1.000 19.91703 ? 180 ASN B O   1 
ATOM   3702 C  CB  . ASN B 1 180 ? 8.90635   -0.74924  8.10899   1.000 19.06109 ? 180 ASN B CB  1 
ATOM   3703 C  CG  . ASN B 1 180 ? 8.25189   -0.65124  9.46449   1.000 20.30416 ? 180 ASN B CG  1 
ATOM   3704 O  OD1 . ASN B 1 180 ? 7.03092   -0.74221  9.57838   1.000 22.85743 ? 180 ASN B OD1 1 
ATOM   3705 N  ND2 . ASN B 1 180 ? 9.05582   -0.48412  10.50194  1.000 17.51504 ? 180 ASN B ND2 1 
ATOM   3706 N  N   . PHE B 1 181 ? 11.22258  0.46017   5.94462   1.000 16.88210 ? 181 PHE B N   1 
ATOM   3707 C  CA  . PHE B 1 181 ? 11.70669  0.34008   4.57902   1.000 19.49738 ? 181 PHE B CA  1 
ATOM   3708 C  C   . PHE B 1 181 ? 11.35546  -1.01510  3.98662   1.000 20.14920 ? 181 PHE B C   1 
ATOM   3709 O  O   . PHE B 1 181 ? 11.28999  -2.03460  4.68350   1.000 19.69079 ? 181 PHE B O   1 
ATOM   3710 C  CB  . PHE B 1 181 ? 13.21693  0.56592   4.50753   1.000 18.82282 ? 181 PHE B CB  1 
ATOM   3711 C  CG  . PHE B 1 181 ? 13.57365  1.89359   3.92397   1.000 19.33840 ? 181 PHE B CG  1 
ATOM   3712 C  CD1 . PHE B 1 181 ? 13.58565  2.07237   2.54498   1.000 18.97399 ? 181 PHE B CD1 1 
ATOM   3713 C  CD2 . PHE B 1 181 ? 13.81724  2.98274   4.74617   1.000 18.72270 ? 181 PHE B CD2 1 
ATOM   3714 C  CE1 . PHE B 1 181 ? 13.86789  3.30027   2.00007   1.000 20.11201 ? 181 PHE B CE1 1 
ATOM   3715 C  CE2 . PHE B 1 181 ? 14.10974  4.22276   4.20290   1.000 22.97098 ? 181 PHE B CE2 1 
ATOM   3716 C  CZ  . PHE B 1 181 ? 14.13150  4.38117   2.82741   1.000 20.04079 ? 181 PHE B CZ  1 
ATOM   3717 N  N   . TYR B 1 182 ? 11.06580  -0.99760  2.68930   1.000 16.98881 ? 182 TYR B N   1 
ATOM   3718 C  CA  . TYR B 1 182 ? 11.12469  -2.19279  1.86671   1.000 17.80143 ? 182 TYR B CA  1 
ATOM   3719 C  C   . TYR B 1 182 ? 12.55169  -2.29172  1.33916   1.000 19.17662 ? 182 TYR B C   1 
ATOM   3720 O  O   . TYR B 1 182 ? 13.02200  -1.37872  0.65754   1.000 17.88473 ? 182 TYR B O   1 
ATOM   3721 C  CB  . TYR B 1 182 ? 10.13725  -2.12368  0.70271   1.000 19.04219 ? 182 TYR B CB  1 
ATOM   3722 C  CG  . TYR B 1 182 ? 8.65899   -2.18880  1.06424   1.000 17.36204 ? 182 TYR B CG  1 
ATOM   3723 C  CD1 . TYR B 1 182 ? 8.06134   -3.39394  1.41433   1.000 17.27287 ? 182 TYR B CD1 1 
ATOM   3724 C  CD2 . TYR B 1 182 ? 7.86017   -1.05586  1.00607   1.000 17.52648 ? 182 TYR B CD2 1 
ATOM   3725 C  CE1 . TYR B 1 182 ? 6.71528   -3.46394  1.72308   1.000 18.96979 ? 182 TYR B CE1 1 
ATOM   3726 C  CE2 . TYR B 1 182 ? 6.51243   -1.11612  1.30216   1.000 15.42423 ? 182 TYR B CE2 1 
ATOM   3727 C  CZ  . TYR B 1 182 ? 5.94784   -2.32208  1.66484   1.000 19.44948 ? 182 TYR B CZ  1 
ATOM   3728 O  OH  . TYR B 1 182 ? 4.60585   -2.39765  1.95911   1.000 20.21228 ? 182 TYR B OH  1 
ATOM   3729 N  N   . GLY B 1 183 ? 13.24079  -3.37544  1.66839   1.000 19.50622 ? 183 GLY B N   1 
ATOM   3730 C  CA  . GLY B 1 183 ? 14.57152  -3.60197  1.15533   1.000 20.42879 ? 183 GLY B CA  1 
ATOM   3731 C  C   . GLY B 1 183 ? 15.66451  -3.07006  2.05158   1.000 20.88403 ? 183 GLY B C   1 
ATOM   3732 O  O   . GLY B 1 183 ? 15.41636  -2.33508  3.01513   1.000 20.03210 ? 183 GLY B O   1 
ATOM   3733 N  N   . PRO B 1 184 ? 16.91403  -3.43119  1.73699   1.000 20.57238 ? 184 PRO B N   1 
ATOM   3734 C  CA  . PRO B 1 184 ? 18.04937  -3.10255  2.61931   1.000 19.39552 ? 184 PRO B CA  1 
ATOM   3735 C  C   . PRO B 1 184 ? 18.56653  -1.68565  2.39530   1.000 23.47028 ? 184 PRO B C   1 
ATOM   3736 O  O   . PRO B 1 184 ? 19.74042  -1.46272  2.08455   1.000 23.14468 ? 184 PRO B O   1 
ATOM   3737 C  CB  . PRO B 1 184 ? 19.08075  -4.17399  2.23560   1.000 20.04225 ? 184 PRO B CB  1 
ATOM   3738 C  CG  . PRO B 1 184 ? 18.83426  -4.42571  0.78857   1.000 20.33374 ? 184 PRO B CG  1 
ATOM   3739 C  CD  . PRO B 1 184 ? 17.31831  -4.25347  0.58173   1.000 17.95777 ? 184 PRO B CD  1 
ATOM   3740 N  N   . PHE B 1 185 ? 17.68206  -0.70394  2.55804   1.000 19.17780 ? 185 PHE B N   1 
ATOM   3741 C  CA  . PHE B 1 185 ? 17.99029  0.67338   2.20222   1.000 21.24698 ? 185 PHE B CA  1 
ATOM   3742 C  C   . PHE B 1 185 ? 17.76019  1.59570   3.39451   1.000 24.12239 ? 185 PHE B C   1 
ATOM   3743 O  O   . PHE B 1 185 ? 16.95736  1.30150   4.28435   1.000 19.02861 ? 185 PHE B O   1 
ATOM   3744 C  CB  . PHE B 1 185 ? 17.13441  1.12733   0.98800   1.000 21.01407 ? 185 PHE B CB  1 
ATOM   3745 C  CG  . PHE B 1 185 ? 17.16562  0.15645   -0.17127  1.000 19.29623 ? 185 PHE B CG  1 
ATOM   3746 C  CD1 . PHE B 1 185 ? 18.34451  -0.06437  -0.87546  1.000 21.67731 ? 185 PHE B CD1 1 
ATOM   3747 C  CD2 . PHE B 1 185 ? 16.02077  -0.54466  -0.54647  1.000 16.98899 ? 185 PHE B CD2 1 
ATOM   3748 C  CE1 . PHE B 1 185 ? 18.38305  -0.95759  -1.93563  1.000 23.48865 ? 185 PHE B CE1 1 
ATOM   3749 C  CE2 . PHE B 1 185 ? 16.05538  -1.44014  -1.59645  1.000 17.30473 ? 185 PHE B CE2 1 
ATOM   3750 C  CZ  . PHE B 1 185 ? 17.23539  -1.64827  -2.29900  1.000 21.86817 ? 185 PHE B CZ  1 
ATOM   3751 N  N   . VAL B 1 186 ? 18.46829  2.72513   3.40308   1.000 19.76026 ? 186 VAL B N   1 
ATOM   3752 C  CA  . VAL B 1 186 ? 18.31601  3.72023   4.45552   1.000 22.13900 ? 186 VAL B CA  1 
ATOM   3753 C  C   . VAL B 1 186 ? 18.10842  5.09094   3.82592   1.000 21.33221 ? 186 VAL B C   1 
ATOM   3754 O  O   . VAL B 1 186 ? 18.59337  5.36837   2.72284   1.000 26.03601 ? 186 VAL B O   1 
ATOM   3755 C  CB  . VAL B 1 186 ? 19.53002  3.74146   5.40824   1.000 20.86654 ? 186 VAL B CB  1 
ATOM   3756 C  CG1 . VAL B 1 186 ? 19.65609  2.40313   6.13398   1.000 20.93765 ? 186 VAL B CG1 1 
ATOM   3757 C  CG2 . VAL B 1 186 ? 20.80447  4.07412   4.63211   1.000 24.49687 ? 186 VAL B CG2 1 
ATOM   3758 N  N   . ASP B 1 187 ? 17.37374  5.95515   4.53306   1.000 19.40423 ? 187 ASP B N   1 
ATOM   3759 C  CA  . ASP B 1 187 ? 17.13163  7.31523   4.04714   1.000 25.58023 ? 187 ASP B CA  1 
ATOM   3760 C  C   . ASP B 1 187 ? 18.33305  8.17964   4.42917   1.000 26.70756 ? 187 ASP B C   1 
ATOM   3761 O  O   . ASP B 1 187 ? 18.30921  8.99165   5.35820   1.000 28.30189 ? 187 ASP B O   1 
ATOM   3762 C  CB  . ASP B 1 187 ? 15.81304  7.87640   4.56954   1.000 21.40527 ? 187 ASP B CB  1 
ATOM   3763 C  CG  . ASP B 1 187 ? 15.61052  7.66096   6.06637   1.000 23.95385 ? 187 ASP B CG  1 
ATOM   3764 O  OD1 . ASP B 1 187 ? 16.45169  7.00949   6.72957   1.000 24.42141 ? 187 ASP B OD1 1 
ATOM   3765 O  OD2 . ASP B 1 187 ? 14.58025  8.15270   6.57535   1.000 25.02289 ? 187 ASP B OD2 1 
ATOM   3766 N  N   . ARG B 1 188 ? 19.41166  7.98233   3.67894   1.000 29.82568 ? 188 ARG B N   1 
ATOM   3767 C  CA  . ARG B 1 188 ? 20.66335  8.69770   3.86862   1.000 34.80394 ? 188 ARG B CA  1 
ATOM   3768 C  C   . ARG B 1 188 ? 21.36526  8.78041   2.52015   1.000 33.81290 ? 188 ARG B C   1 
ATOM   3769 O  O   . ARG B 1 188 ? 21.33531  7.82649   1.73721   1.000 28.07933 ? 188 ARG B O   1 
ATOM   3770 C  CB  . ARG B 1 188 ? 21.53473  7.99921   4.92271   1.000 34.44015 ? 188 ARG B CB  1 
ATOM   3771 C  CG  . ARG B 1 188 ? 23.01045  8.37005   4.91263   1.000 40.36948 ? 188 ARG B CG  1 
ATOM   3772 C  CD  . ARG B 1 188 ? 23.63043  8.13901   6.28912   1.000 42.83220 ? 188 ARG B CD  1 
ATOM   3773 N  NE  . ARG B 1 188 ? 24.98120  7.59128   6.22498   1.000 46.98525 ? 188 ARG B NE  1 
ATOM   3774 C  CZ  . ARG B 1 188 ? 25.30785  6.36358   6.61052   1.000 46.79290 ? 188 ARG B CZ  1 
ATOM   3775 N  NH1 . ARG B 1 188 ? 24.40711  5.53109   7.12035   1.000 44.51676 ? 188 ARG B NH1 1 
ATOM   3776 N  NH2 . ARG B 1 188 ? 26.56667  5.95858   6.48236   1.000 46.89713 ? 188 ARG B NH2 1 
ATOM   3777 N  N   . GLN B 1 189 ? 21.97872  9.93264   2.25141   1.000 36.30699 ? 189 GLN B N   1 
ATOM   3778 C  CA  . GLN B 1 189 ? 22.63060  10.20515  0.97136   1.000 39.70160 ? 189 GLN B CA  1 
ATOM   3779 C  C   . GLN B 1 189 ? 24.00674  9.54653   0.96084   1.000 41.62534 ? 189 GLN B C   1 
ATOM   3780 O  O   . GLN B 1 189 ? 25.04073  10.18688  1.15865   1.000 45.95993 ? 189 GLN B O   1 
ATOM   3781 C  CB  . GLN B 1 189 ? 22.73020  11.70763  0.74580   1.000 45.58108 ? 189 GLN B CB  1 
ATOM   3782 C  CG  . GLN B 1 189 ? 23.03303  12.11973  -0.68042  1.000 55.36132 ? 189 GLN B CG  1 
ATOM   3783 C  CD  . GLN B 1 189 ? 22.63692  13.56145  -0.94601  1.000 62.61903 ? 189 GLN B CD  1 
ATOM   3784 O  OE1 . GLN B 1 189 ? 21.71804  13.83320  -1.72319  1.000 66.70443 ? 189 GLN B OE1 1 
ATOM   3785 N  NE2 . GLN B 1 189 ? 23.32120  14.49520  -0.28792  1.000 58.23502 ? 189 GLN B NE2 1 
ATOM   3786 N  N   . ILE B 1 190 ? 24.01037  8.22931   0.74414   1.000 39.04811 ? 190 ILE B N   1 
ATOM   3787 C  CA  . ILE B 1 190 ? 25.22960  7.43471   0.64249   1.000 37.71405 ? 190 ILE B CA  1 
ATOM   3788 C  C   . ILE B 1 190 ? 25.04065  6.40103   -0.45869  1.000 40.15599 ? 190 ILE B C   1 
ATOM   3789 O  O   . ILE B 1 190 ? 23.92642  6.13967   -0.91436  1.000 38.04147 ? 190 ILE B O   1 
ATOM   3790 C  CB  . ILE B 1 190 ? 25.60007  6.71956   1.95675   1.000 38.10307 ? 190 ILE B CB  1 
ATOM   3791 C  CG1 . ILE B 1 190 ? 24.42987  5.84746   2.41988   1.000 41.43215 ? 190 ILE B CG1 1 
ATOM   3792 C  CG2 . ILE B 1 190 ? 26.04082  7.71996   3.01754   1.000 44.54606 ? 190 ILE B CG2 1 
ATOM   3793 C  CD1 . ILE B 1 190 ? 24.81048  4.79520   3.42482   1.000 40.52086 ? 190 ILE B CD1 1 
ATOM   3794 N  N   . ALA B 1 191 ? 26.15318  5.79306   -0.86229  1.000 37.69741 ? 191 ALA B N   1 
ATOM   3795 C  CA  . ALA B 1 191 ? 26.13922  4.78911   -1.91775  1.000 35.77237 ? 191 ALA B CA  1 
ATOM   3796 C  C   . ALA B 1 191 ? 25.34524  3.56898   -1.47166  1.000 33.32612 ? 191 ALA B C   1 
ATOM   3797 O  O   . ALA B 1 191 ? 25.67454  2.94015   -0.46112  1.000 33.55437 ? 191 ALA B O   1 
ATOM   3798 C  CB  . ALA B 1 191 ? 27.56774  4.39172   -2.28110  1.000 37.10115 ? 191 ALA B CB  1 
ATOM   3799 N  N   . GLN B 1 192 ? 24.29612  3.23926   -2.22264  1.000 33.63425 ? 192 GLN B N   1 
ATOM   3800 C  CA  . GLN B 1 192 ? 23.44643  2.09103   -1.93976  1.000 31.86717 ? 192 GLN B CA  1 
ATOM   3801 C  C   . GLN B 1 192 ? 23.05115  1.42686   -3.24542  1.000 30.65368 ? 192 GLN B C   1 
ATOM   3802 O  O   . GLN B 1 192 ? 22.67580  2.10825   -4.20268  1.000 31.68789 ? 192 GLN B O   1 
ATOM   3803 C  CB  . GLN B 1 192 ? 22.16972  2.48992   -1.19288  1.000 28.21443 ? 192 GLN B CB  1 
ATOM   3804 C  CG  . GLN B 1 192 ? 22.38168  3.43245   -0.03807  1.000 28.98474 ? 192 GLN B CG  1 
ATOM   3805 C  CD  . GLN B 1 192 ? 21.09403  3.71256   0.67256   1.000 27.41372 ? 192 GLN B CD  1 
ATOM   3806 O  OE1 . GLN B 1 192 ? 20.38322  2.78955   1.04541   1.000 22.08575 ? 192 GLN B OE1 1 
ATOM   3807 N  NE2 . GLN B 1 192 ? 20.76640  4.98515   0.84012   1.000 29.18323 ? 192 GLN B NE2 1 
ATOM   3808 N  N   . ALA B 1 193 ? 23.11511  0.09821   -3.27275  1.000 30.75293 ? 193 ALA B N   1 
ATOM   3809 C  CA  . ALA B 1 193 ? 22.71873  -0.66851  -4.44392  1.000 37.23715 ? 193 ALA B CA  1 
ATOM   3810 C  C   . ALA B 1 193 ? 21.77094  -1.78440  -4.03470  1.000 29.78500 ? 193 ALA B C   1 
ATOM   3811 O  O   . ALA B 1 193 ? 21.93123  -2.39317  -2.97203  1.000 31.82273 ? 193 ALA B O   1 
ATOM   3812 C  CB  . ALA B 1 193 ? 23.93416  -1.25886  -5.17339  1.000 32.67791 ? 193 ALA B CB  1 
ATOM   3813 N  N   . ALA B 1 194 ? 20.78548  -2.04819  -4.88570  1.000 32.55122 ? 194 ALA B N   1 
ATOM   3814 C  CA  . ALA B 1 194 ? 19.89786  -3.17874  -4.67844  1.000 29.65965 ? 194 ALA B CA  1 
ATOM   3815 C  C   . ALA B 1 194 ? 20.58020  -4.47516  -5.09500  1.000 31.55365 ? 194 ALA B C   1 
ATOM   3816 O  O   . ALA B 1 194 ? 21.48887  -4.48542  -5.92555  1.000 40.66382 ? 194 ALA B O   1 
ATOM   3817 C  CB  . ALA B 1 194 ? 18.60310  -2.99516  -5.46810  1.000 25.93041 ? 194 ALA B CB  1 
ATOM   3818 N  N   . GLY B 1 195 ? 20.12831  -5.57461  -4.51134  1.000 35.86919 ? 195 GLY B N   1 
ATOM   3819 C  CA  . GLY B 1 195 ? 20.60046  -6.87499  -4.92196  1.000 32.24909 ? 195 GLY B CA  1 
ATOM   3820 C  C   . GLY B 1 195 ? 20.15426  -7.21635  -6.32951  1.000 36.97581 ? 195 GLY B C   1 
ATOM   3821 O  O   . GLY B 1 195 ? 19.30786  -6.55838  -6.94091  1.000 33.96980 ? 195 GLY B O   1 
ATOM   3822 N  N   . THR B 1 196 ? 20.76021  -8.27293  -6.85864  1.000 34.57503 ? 196 THR B N   1 
ATOM   3823 C  CA  . THR B 1 196 ? 20.41512  -8.73794  -8.19201  1.000 34.59277 ? 196 THR B CA  1 
ATOM   3824 C  C   . THR B 1 196 ? 18.93427  -9.07823  -8.24952  1.000 34.14615 ? 196 THR B C   1 
ATOM   3825 O  O   . THR B 1 196 ? 18.42296  -9.83661  -7.42231  1.000 36.06045 ? 196 THR B O   1 
ATOM   3826 C  CB  . THR B 1 196 ? 21.26163  -9.95448  -8.56830  1.000 39.51086 ? 196 THR B CB  1 
ATOM   3827 O  OG1 . THR B 1 196 ? 22.61562  -9.53459  -8.79717  1.000 40.63522 ? 196 THR B OG1 1 
ATOM   3828 C  CG2 . THR B 1 196 ? 20.71356  -10.61692 -9.83545  1.000 40.67721 ? 196 THR B CG2 1 
ATOM   3829 N  N   . ASP B 1 197 ? 18.23789  -8.48996  -9.20980  1.000 35.37849 ? 197 ASP B N   1 
ATOM   3830 C  CA  . ASP B 1 197 ? 16.81584  -8.74949  -9.29026  1.000 35.20367 ? 197 ASP B CA  1 
ATOM   3831 C  C   . ASP B 1 197 ? 16.55626  -10.08466 -9.97123  1.000 34.77984 ? 197 ASP B C   1 
ATOM   3832 O  O   . ASP B 1 197 ? 17.42374  -10.66392 -10.63391 1.000 36.61188 ? 197 ASP B O   1 
ATOM   3833 C  CB  . ASP B 1 197 ? 16.09194  -7.63588  -10.03723 1.000 28.61961 ? 197 ASP B CB  1 
ATOM   3834 C  CG  . ASP B 1 197 ? 14.62974  -7.52231  -9.62643  1.000 29.61486 ? 197 ASP B CG  1 
ATOM   3835 O  OD1 . ASP B 1 197 ? 14.24706  -8.10774  -8.58539  1.000 26.99888 ? 197 ASP B OD1 1 
ATOM   3836 O  OD2 . ASP B 1 197 ? 13.86989  -6.84985  -10.34377 1.000 26.46566 ? 197 ASP B OD2 1 
ATOM   3837 N  N   . THR B 1 198 ? 15.34054  -10.57804 -9.77491  1.000 31.08807 ? 198 THR B N   1 
ATOM   3838 C  CA  . THR B 1 198 ? 14.89013  -11.81950 -10.37002 1.000 29.43423 ? 198 THR B CA  1 
ATOM   3839 C  C   . THR B 1 198 ? 13.49142  -11.59636 -10.91992 1.000 33.37587 ? 198 THR B C   1 
ATOM   3840 O  O   . THR B 1 198 ? 12.82614  -10.60580 -10.60195 1.000 26.05964 ? 198 THR B O   1 
ATOM   3841 C  CB  . THR B 1 198 ? 14.90733  -12.96942 -9.35940  1.000 35.55354 ? 198 THR B CB  1 
ATOM   3842 O  OG1 . THR B 1 198 ? 14.27424  -12.54836 -8.14471  1.000 31.11229 ? 198 THR B OG1 1 
ATOM   3843 C  CG2 . THR B 1 198 ? 16.34725  -13.38561 -9.04897  1.000 38.25087 ? 198 THR B CG2 1 
ATOM   3844 N  N   . THR B 1 199 ? 13.05296  -12.53162 -11.75511 1.000 28.87016 ? 199 THR B N   1 
ATOM   3845 C  CA  . THR B 1 199 ? 11.75017  -12.45166 -12.39455 1.000 27.50934 ? 199 THR B CA  1 
ATOM   3846 C  C   . THR B 1 199 ? 10.71402  -13.16337 -11.53541 1.000 26.10109 ? 199 THR B C   1 
ATOM   3847 O  O   . THR B 1 199 ? 10.99146  -14.21714 -10.95260 1.000 26.31142 ? 199 THR B O   1 
ATOM   3848 C  CB  . THR B 1 199 ? 11.80468  -13.06858 -13.79847 1.000 25.01558 ? 199 THR B CB  1 
ATOM   3849 O  OG1 . THR B 1 199 ? 12.76562  -12.36075 -14.58704 1.000 24.72387 ? 199 THR B OG1 1 
ATOM   3850 C  CG2 . THR B 1 199 ? 10.44279  -12.97696 -14.48295 1.000 25.78451 ? 199 THR B CG2 1 
ATOM   3851 N  N   . ILE B 1 200 ? 9.51344   -12.58222 -11.46267 1.000 23.13006 ? 200 ILE B N   1 
ATOM   3852 C  CA  . ILE B 1 200 ? 8.46745   -13.11744 -10.60334 1.000 21.79787 ? 200 ILE B CA  1 
ATOM   3853 C  C   . ILE B 1 200 ? 7.74207   -14.23285 -11.34587 1.000 24.03378 ? 200 ILE B C   1 
ATOM   3854 O  O   . ILE B 1 200 ? 6.74296   -13.99280 -12.03729 1.000 19.54519 ? 200 ILE B O   1 
ATOM   3855 C  CB  . ILE B 1 200 ? 7.49518   -12.01245 -10.15429 1.000 20.69909 ? 200 ILE B CB  1 
ATOM   3856 C  CG1 . ILE B 1 200 ? 8.28847   -10.80974 -9.63412  1.000 18.72628 ? 200 ILE B CG1 1 
ATOM   3857 C  CG2 . ILE B 1 200 ? 6.53601   -12.55828 -9.10687  1.000 16.17359 ? 200 ILE B CG2 1 
ATOM   3858 C  CD1 . ILE B 1 200 ? 7.49426   -9.50972  -9.60359  1.000 20.64843 ? 200 ILE B CD1 1 
ATOM   3859 N  N   . THR B 1 201 ? 8.21427   -15.46708 -11.14980 1.000 23.12633 ? 201 THR B N   1 
ATOM   3860 C  CA  . THR B 1 201 ? 7.75549   -16.61039 -11.93037 1.000 20.60345 ? 201 THR B CA  1 
ATOM   3861 C  C   . THR B 1 201 ? 6.23836   -16.75920 -11.90419 1.000 21.75496 ? 201 THR B C   1 
ATOM   3862 O  O   . THR B 1 201 ? 5.60294   -16.92432 -12.95255 1.000 20.14194 ? 201 THR B O   1 
ATOM   3863 C  CB  . THR B 1 201 ? 8.42387   -17.88085 -11.40762 1.000 23.92343 ? 201 THR B CB  1 
ATOM   3864 O  OG1 . THR B 1 201 ? 9.83460   -17.65935 -11.34121 1.000 25.13119 ? 201 THR B OG1 1 
ATOM   3865 C  CG2 . THR B 1 201 ? 8.13853   -19.04981 -12.33534 1.000 27.45105 ? 201 THR B CG2 1 
ATOM   3866 N  N   . VAL B 1 202 ? 5.63689   -16.71343 -10.71296 1.000 20.14458 ? 202 VAL B N   1 
ATOM   3867 C  CA  . VAL B 1 202 ? 4.20365   -16.96383 -10.61693 1.000 16.57769 ? 202 VAL B CA  1 
ATOM   3868 C  C   . VAL B 1 202 ? 3.41876   -15.90257 -11.38412 1.000 19.12290 ? 202 VAL B C   1 
ATOM   3869 O  O   . VAL B 1 202 ? 2.33538   -16.18211 -11.90710 1.000 19.34869 ? 202 VAL B O   1 
ATOM   3870 C  CB  . VAL B 1 202 ? 3.77320   -17.04259 -9.14022  1.000 21.72596 ? 202 VAL B CB  1 
ATOM   3871 C  CG1 . VAL B 1 202 ? 4.02742   -15.71997 -8.44094  1.000 20.92526 ? 202 VAL B CG1 1 
ATOM   3872 C  CG2 . VAL B 1 202 ? 2.30223   -17.45874 -9.03347  1.000 23.70987 ? 202 VAL B CG2 1 
ATOM   3873 N  N   . ASN B 1 203 ? 3.95716   -14.68134 -11.47968 1.000 17.35908 ? 203 ASN B N   1 
ATOM   3874 C  CA  . ASN B 1 203 ? 3.29620   -13.62937 -12.24812 1.000 19.84712 ? 203 ASN B CA  1 
ATOM   3875 C  C   . ASN B 1 203 ? 3.41498   -13.87704 -13.75146 1.000 18.90903 ? 203 ASN B C   1 
ATOM   3876 O  O   . ASN B 1 203 ? 2.44333   -13.68386 -14.48890 1.000 16.45092 ? 203 ASN B O   1 
ATOM   3877 C  CB  . ASN B 1 203 ? 3.87450   -12.26113 -11.87273 1.000 18.13936 ? 203 ASN B CB  1 
ATOM   3878 C  CG  . ASN B 1 203 ? 3.40313   -11.77329 -10.49870 1.000 20.44316 ? 203 ASN B CG  1 
ATOM   3879 O  OD1 . ASN B 1 203 ? 2.74903   -12.50292 -9.75592  1.000 18.28641 ? 203 ASN B OD1 1 
ATOM   3880 N  ND2 . ASN B 1 203 ? 3.74974   -10.53672 -10.15993 1.000 17.32195 ? 203 ASN B ND2 1 
ATOM   3881 N  N   . VAL B 1 204 ? 4.59297   -14.30613 -14.22577 1.000 16.15605 ? 204 VAL B N   1 
ATOM   3882 C  CA  . VAL B 1 204 ? 4.74217   -14.67178 -15.63615 1.000 17.27370 ? 204 VAL B CA  1 
ATOM   3883 C  C   . VAL B 1 204 ? 3.72432   -15.73655 -16.02299 1.000 19.78693 ? 204 VAL B C   1 
ATOM   3884 O  O   . VAL B 1 204 ? 3.08298   -15.65637 -17.07843 1.000 20.35438 ? 204 VAL B O   1 
ATOM   3885 C  CB  . VAL B 1 204 ? 6.17279   -15.15332 -15.93924 1.000 19.56754 ? 204 VAL B CB  1 
ATOM   3886 C  CG1 . VAL B 1 204 ? 6.27497   -15.54322 -17.43284 1.000 17.46371 ? 204 VAL B CG1 1 
ATOM   3887 C  CG2 . VAL B 1 204 ? 7.19489   -14.08130 -15.59823 1.000 18.95209 ? 204 VAL B CG2 1 
ATOM   3888 N  N   . LEU B 1 205 ? 3.57404   -16.76139 -15.18263 1.000 20.68635 ? 205 LEU B N   1 
ATOM   3889 C  CA  . LEU B 1 205 ? 2.60786   -17.81379 -15.48000 1.000 20.07715 ? 205 LEU B CA  1 
ATOM   3890 C  C   . LEU B 1 205 ? 1.19314   -17.25769 -15.55387 1.000 22.64252 ? 205 LEU B C   1 
ATOM   3891 O  O   . LEU B 1 205 ? 0.40953   -17.64330 -16.43019 1.000 19.67147 ? 205 LEU B O   1 
ATOM   3892 C  CB  . LEU B 1 205 ? 2.69062   -18.91670 -14.42583 1.000 19.61370 ? 205 LEU B CB  1 
ATOM   3893 C  CG  . LEU B 1 205 ? 4.02330   -19.67361 -14.39947 1.000 24.12465 ? 205 LEU B CG  1 
ATOM   3894 C  CD1 . LEU B 1 205 ? 4.09928   -20.58977 -13.18689 1.000 25.63385 ? 205 LEU B CD1 1 
ATOM   3895 C  CD2 . LEU B 1 205 ? 4.20583   -20.46587 -15.68835 1.000 23.11596 ? 205 LEU B CD2 1 
ATOM   3896 N  N   . ALA B 1 206 ? 0.84334   -16.35488 -14.63724 1.000 21.28446 ? 206 ALA B N   1 
ATOM   3897 C  CA  . ALA B 1 206 ? -0.49475  -15.77030 -14.67061 1.000 19.76982 ? 206 ALA B CA  1 
ATOM   3898 C  C   . ALA B 1 206 ? -0.72524  -15.03651 -15.98269 1.000 18.62873 ? 206 ALA B C   1 
ATOM   3899 O  O   . ALA B 1 206 ? -1.80429  -15.12811 -16.57918 1.000 21.64573 ? 206 ALA B O   1 
ATOM   3900 C  CB  . ALA B 1 206 ? -0.68375  -14.81979 -13.48831 1.000 17.27911 ? 206 ALA B CB  1 
ATOM   3901 N  N   . TRP B 1 207 ? 0.29536   -14.31834 -16.45201 1.000 18.46216 ? 207 TRP B N   1 
ATOM   3902 C  CA  . TRP B 1 207 ? 0.19813   -13.55221 -17.69163 1.000 22.06815 ? 207 TRP B CA  1 
ATOM   3903 C  C   . TRP B 1 207 ? 0.09668   -14.47114 -18.90590 1.000 21.56407 ? 207 TRP B C   1 
ATOM   3904 O  O   . TRP B 1 207 ? -0.61455  -14.16375 -19.86940 1.000 19.40152 ? 207 TRP B O   1 
ATOM   3905 C  CB  . TRP B 1 207 ? 1.40920   -12.61704 -17.78421 1.000 19.29533 ? 207 TRP B CB  1 
ATOM   3906 C  CG  . TRP B 1 207 ? 1.60441   -11.84926 -19.06410 1.000 21.74542 ? 207 TRP B CG  1 
ATOM   3907 C  CD1 . TRP B 1 207 ? 0.95319   -10.70693 -19.46117 1.000 25.17812 ? 207 TRP B CD1 1 
ATOM   3908 C  CD2 . TRP B 1 207 ? 2.57950   -12.12640 -20.08050 1.000 23.28180 ? 207 TRP B CD2 1 
ATOM   3909 N  NE1 . TRP B 1 207 ? 1.45060   -10.28054 -20.67865 1.000 20.95022 ? 207 TRP B NE1 1 
ATOM   3910 C  CE2 . TRP B 1 207 ? 2.44569   -11.13553 -21.07520 1.000 20.61251 ? 207 TRP B CE2 1 
ATOM   3911 C  CE3 . TRP B 1 207 ? 3.53541   -13.12954 -20.25252 1.000 19.72551 ? 207 TRP B CE3 1 
ATOM   3912 C  CZ2 . TRP B 1 207 ? 3.23310   -11.11893 -22.21408 1.000 23.65121 ? 207 TRP B CZ2 1 
ATOM   3913 C  CZ3 . TRP B 1 207 ? 4.31677   -13.10846 -21.39142 1.000 25.81789 ? 207 TRP B CZ3 1 
ATOM   3914 C  CH2 . TRP B 1 207 ? 4.16322   -12.10858 -22.35423 1.000 23.19410 ? 207 TRP B CH2 1 
ATOM   3915 N  N   . LEU B 1 208 ? 0.78036   -15.61586 -18.87301 1.000 20.16426 ? 208 LEU B N   1 
ATOM   3916 C  CA  . LEU B 1 208 ? 0.58759   -16.59970 -19.93481 1.000 21.12611 ? 208 LEU B CA  1 
ATOM   3917 C  C   . LEU B 1 208 ? -0.84459  -17.12703 -19.93274 1.000 21.22451 ? 208 LEU B C   1 
ATOM   3918 O  O   . LEU B 1 208 ? -1.42270  -17.37843 -20.99465 1.000 23.01713 ? 208 LEU B O   1 
ATOM   3919 C  CB  . LEU B 1 208 ? 1.60124   -17.74247 -19.79392 1.000 20.16315 ? 208 LEU B CB  1 
ATOM   3920 C  CG  . LEU B 1 208 ? 3.07379   -17.32909 -19.94919 1.000 20.03120 ? 208 LEU B CG  1 
ATOM   3921 C  CD1 . LEU B 1 208 ? 4.05610   -18.49126 -19.68541 1.000 19.71166 ? 208 LEU B CD1 1 
ATOM   3922 C  CD2 . LEU B 1 208 ? 3.32010   -16.74288 -21.32685 1.000 25.96355 ? 208 LEU B CD2 1 
ATOM   3923 N  N   . TYR B 1 209 ? -1.44540  -17.27672 -18.74956 1.000 21.57562 ? 209 TYR B N   1 
ATOM   3924 C  CA  . TYR B 1 209 ? -2.85419  -17.66006 -18.69415 1.000 21.05129 ? 209 TYR B CA  1 
ATOM   3925 C  C   . TYR B 1 209 ? -3.75034  -16.56409 -19.26974 1.000 22.56980 ? 209 TYR B C   1 
ATOM   3926 O  O   . TYR B 1 209 ? -4.69969  -16.85765 -20.00146 1.000 23.89430 ? 209 TYR B O   1 
ATOM   3927 C  CB  . TYR B 1 209 ? -3.26658  -17.99028 -17.26024 1.000 24.38590 ? 209 TYR B CB  1 
ATOM   3928 C  CG  . TYR B 1 209 ? -2.90202  -19.38942 -16.80541 1.000 25.90936 ? 209 TYR B CG  1 
ATOM   3929 C  CD1 . TYR B 1 209 ? -3.57973  -20.50180 -17.28979 1.000 30.56449 ? 209 TYR B CD1 1 
ATOM   3930 C  CD2 . TYR B 1 209 ? -1.90543  -19.59354 -15.86206 1.000 26.01544 ? 209 TYR B CD2 1 
ATOM   3931 C  CE1 . TYR B 1 209 ? -3.25317  -21.78418 -16.86420 1.000 30.04582 ? 209 TYR B CE1 1 
ATOM   3932 C  CE2 . TYR B 1 209 ? -1.56989  -20.86144 -15.43493 1.000 27.64011 ? 209 TYR B CE2 1 
ATOM   3933 C  CZ  . TYR B 1 209 ? -2.24444  -21.95803 -15.93815 1.000 33.90493 ? 209 TYR B CZ  1 
ATOM   3934 O  OH  . TYR B 1 209 ? -1.89785  -23.22415 -15.49869 1.000 31.71767 ? 209 TYR B OH  1 
ATOM   3935 N  N   . ALA B 1 210 ? -3.47053  -15.29574 -18.95130 1.000 21.22701 ? 210 ALA B N   1 
ATOM   3936 C  CA  . ALA B 1 210 ? -4.20662  -14.20424 -19.58880 1.000 22.83784 ? 210 ALA B CA  1 
ATOM   3937 C  C   . ALA B 1 210 ? -4.05246  -14.24492 -21.10825 1.000 24.50561 ? 210 ALA B C   1 
ATOM   3938 O  O   . ALA B 1 210 ? -5.00624  -13.96983 -21.84713 1.000 22.05432 ? 210 ALA B O   1 
ATOM   3939 C  CB  . ALA B 1 210 ? -3.73716  -12.85540 -19.04092 1.000 18.55238 ? 210 ALA B CB  1 
ATOM   3940 N  N   . ALA B 1 211 ? -2.85424  -14.58740 -21.59266 1.000 21.32508 ? 211 ALA B N   1 
ATOM   3941 C  CA  . ALA B 1 211 ? -2.63919  -14.70271 -23.02979 1.000 24.40050 ? 211 ALA B CA  1 
ATOM   3942 C  C   . ALA B 1 211 ? -3.52795  -15.78541 -23.62981 1.000 27.48808 ? 211 ALA B C   1 
ATOM   3943 O  O   . ALA B 1 211 ? -4.17824  -15.57211 -24.66092 1.000 26.17192 ? 211 ALA B O   1 
ATOM   3944 C  CB  . ALA B 1 211 ? -1.16745  -14.99610 -23.31454 1.000 20.29473 ? 211 ALA B CB  1 
ATOM   3945 N  N   . VAL B 1 212 ? -3.56725  -16.95941 -22.99209 1.000 23.44931 ? 212 VAL B N   1 
ATOM   3946 C  CA  . VAL B 1 212 ? -4.42348  -18.03843 -23.47529 1.000 24.10716 ? 212 VAL B CA  1 
ATOM   3947 C  C   . VAL B 1 212 ? -5.88459  -17.60351 -23.47264 1.000 26.63838 ? 212 VAL B C   1 
ATOM   3948 O  O   . VAL B 1 212 ? -6.61813  -17.84334 -24.43737 1.000 28.70678 ? 212 VAL B O   1 
ATOM   3949 C  CB  . VAL B 1 212 ? -4.20712  -19.30977 -22.63485 1.000 26.22309 ? 212 VAL B CB  1 
ATOM   3950 C  CG1 . VAL B 1 212 ? -5.21661  -20.38570 -23.02698 1.000 27.49919 ? 212 VAL B CG1 1 
ATOM   3951 C  CG2 . VAL B 1 212 ? -2.79639  -19.81884 -22.81850 1.000 21.29138 ? 212 VAL B CG2 1 
ATOM   3952 N  N   . ILE B 1 213 ? -6.32338  -16.94103 -22.39916 1.000 25.73277 ? 213 ILE B N   1 
ATOM   3953 C  CA  . ILE B 1 213 ? -7.70735  -16.47874 -22.30602 1.000 30.34917 ? 213 ILE B CA  1 
ATOM   3954 C  C   . ILE B 1 213 ? -8.05044  -15.54272 -23.45891 1.000 30.20987 ? 213 ILE B C   1 
ATOM   3955 O  O   . ILE B 1 213 ? -9.19642  -15.51191 -23.92800 1.000 30.51719 ? 213 ILE B O   1 
ATOM   3956 C  CB  . ILE B 1 213 ? -7.94132  -15.81688 -20.93008 1.000 31.64396 ? 213 ILE B CB  1 
ATOM   3957 C  CG1 . ILE B 1 213 ? -7.93608  -16.88079 -19.82814 1.000 29.93234 ? 213 ILE B CG1 1 
ATOM   3958 C  CG2 . ILE B 1 213 ? -9.24249  -15.01469 -20.91501 1.000 31.52050 ? 213 ILE B CG2 1 
ATOM   3959 C  CD1 . ILE B 1 213 ? -7.85516  -16.32095 -18.41210 1.000 26.35066 ? 213 ILE B CD1 1 
ATOM   3960 N  N   . ASN B 1 214 ? -7.06809  -14.80065 -23.96036 1.000 24.59544 ? 214 ASN B N   1 
ATOM   3961 C  CA  . ASN B 1 214 ? -7.26950  -13.84878 -25.04010 1.000 26.43760 ? 214 ASN B CA  1 
ATOM   3962 C  C   . ASN B 1 214 ? -6.93185  -14.41029 -26.41771 1.000 31.81814 ? 214 ASN B C   1 
ATOM   3963 O  O   . ASN B 1 214 ? -6.80806  -13.63561 -27.37137 1.000 30.13092 ? 214 ASN B O   1 
ATOM   3964 C  CB  . ASN B 1 214 ? -6.44859  -12.58662 -24.78448 1.000 25.86772 ? 214 ASN B CB  1 
ATOM   3965 C  CG  . ASN B 1 214 ? -7.15865  -11.61762 -23.86745 1.000 30.39690 ? 214 ASN B CG  1 
ATOM   3966 O  OD1 . ASN B 1 214 ? -7.96221  -10.79770 -24.32152 1.000 31.02867 ? 214 ASN B OD1 1 
ATOM   3967 N  ND2 . ASN B 1 214 ? -6.88071  -11.71139 -22.56619 1.000 27.42682 ? 214 ASN B ND2 1 
ATOM   3968 N  N   . GLY B 1 215 ? -6.77923  -15.72823 -26.54620 1.000 29.16645 ? 215 GLY B N   1 
ATOM   3969 C  CA  . GLY B 1 215 ? -6.57545  -16.35314 -27.83453 1.000 27.85345 ? 215 GLY B CA  1 
ATOM   3970 C  C   . GLY B 1 215 ? -5.14000  -16.54235 -28.26796 1.000 32.32106 ? 215 GLY B C   1 
ATOM   3971 O  O   . GLY B 1 215 ? -4.91407  -17.06027 -29.36665 1.000 33.93014 ? 215 GLY B O   1 
ATOM   3972 N  N   . ASP B 1 216 ? -4.16591  -16.14103 -27.45279 1.000 31.27408 ? 216 ASP B N   1 
ATOM   3973 C  CA  . ASP B 1 216 ? -2.74911  -16.31636 -27.76416 1.000 34.25287 ? 216 ASP B CA  1 
ATOM   3974 C  C   . ASP B 1 216 ? -2.29912  -17.67947 -27.24689 1.000 34.07139 ? 216 ASP B C   1 
ATOM   3975 O  O   . ASP B 1 216 ? -2.13972  -17.86436 -26.03670 1.000 35.17709 ? 216 ASP B O   1 
ATOM   3976 C  CB  . ASP B 1 216 ? -1.91996  -15.19990 -27.13598 1.000 38.05706 ? 216 ASP B CB  1 
ATOM   3977 C  CG  . ASP B 1 216 ? -1.25788  -14.31517 -28.16592 1.000 40.51335 ? 216 ASP B CG  1 
ATOM   3978 O  OD1 . ASP B 1 216 ? -1.28217  -14.66974 -29.36284 1.000 42.40303 ? 216 ASP B OD1 1 
ATOM   3979 O  OD2 . ASP B 1 216 ? -0.71190  -13.26284 -27.76972 1.000 42.47795 ? 216 ASP B OD2 1 
ATOM   3980 N  N   . ARG B 1 217 ? -2.06479  -18.62409 -28.16628 1.000 34.18336 ? 217 ARG B N   1 
ATOM   3981 C  CA  . ARG B 1 217 ? -1.91586  -20.03157 -27.82106 1.000 33.78583 ? 217 ARG B CA  1 
ATOM   3982 C  C   . ARG B 1 217 ? -0.65699  -20.70281 -28.34848 1.000 34.16791 ? 217 ARG B C   1 
ATOM   3983 O  O   . ARG B 1 217 ? -0.44472  -21.88357 -28.04571 1.000 35.81503 ? 217 ARG B O   1 
ATOM   3984 C  CB  . ARG B 1 217 ? -3.11855  -20.84204 -28.34138 1.000 38.18608 ? 217 ARG B CB  1 
ATOM   3985 C  CG  . ARG B 1 217 ? -4.38024  -20.71922 -27.52299 1.000 39.43047 ? 217 ARG B CG  1 
ATOM   3986 C  CD  . ARG B 1 217 ? -5.18505  -22.01260 -27.54308 1.000 38.39364 ? 217 ARG B CD  1 
ATOM   3987 N  NE  . ARG B 1 217 ? -6.10361  -22.05768 -26.41029 1.000 43.12694 ? 217 ARG B NE  1 
ATOM   3988 C  CZ  . ARG B 1 217 ? -6.37132  -23.14376 -25.69689 1.000 39.78995 ? 217 ARG B CZ  1 
ATOM   3989 N  NH1 . ARG B 1 217 ? -5.82392  -24.31249 -25.98649 1.000 35.54459 ? 217 ARG B NH1 1 
ATOM   3990 N  NH2 . ARG B 1 217 ? -7.19813  -23.05002 -24.65665 1.000 45.79523 ? 217 ARG B NH2 1 
ATOM   3991 N  N   . TRP B 1 218 ? 0.16822   -20.01135 -29.13942 1.000 31.52361 ? 218 TRP B N   1 
ATOM   3992 C  CA  . TRP B 1 218 ? 1.22400   -20.69647 -29.87539 1.000 32.32373 ? 218 TRP B CA  1 
ATOM   3993 C  C   . TRP B 1 218 ? 2.27172   -21.33275 -28.96654 1.000 32.80971 ? 218 TRP B C   1 
ATOM   3994 O  O   . TRP B 1 218 ? 2.96880   -22.25350 -29.40740 1.000 32.23990 ? 218 TRP B O   1 
ATOM   3995 C  CB  . TRP B 1 218 ? 1.90015   -19.73163 -30.85571 1.000 32.52016 ? 218 TRP B CB  1 
ATOM   3996 C  CG  . TRP B 1 218 ? 2.57916   -18.57069 -30.20044 1.000 32.18229 ? 218 TRP B CG  1 
ATOM   3997 C  CD1 . TRP B 1 218 ? 2.06790   -17.31810 -30.01279 1.000 34.90700 ? 218 TRP B CD1 1 
ATOM   3998 C  CD2 . TRP B 1 218 ? 3.89483   -18.55366 -29.64179 1.000 37.28657 ? 218 TRP B CD2 1 
ATOM   3999 N  NE1 . TRP B 1 218 ? 2.98638   -16.52160 -29.36453 1.000 32.47605 ? 218 TRP B NE1 1 
ATOM   4000 C  CE2 . TRP B 1 218 ? 4.11564   -17.25694 -29.12666 1.000 34.02971 ? 218 TRP B CE2 1 
ATOM   4001 C  CE3 . TRP B 1 218 ? 4.91084   -19.51007 -29.52315 1.000 35.81402 ? 218 TRP B CE3 1 
ATOM   4002 C  CZ2 . TRP B 1 218 ? 5.31048   -16.89299 -28.51346 1.000 37.28624 ? 218 TRP B CZ2 1 
ATOM   4003 C  CZ3 . TRP B 1 218 ? 6.09305   -19.14854 -28.91191 1.000 34.92776 ? 218 TRP B CZ3 1 
ATOM   4004 C  CH2 . TRP B 1 218 ? 6.28530   -17.85166 -28.41337 1.000 40.77437 ? 218 TRP B CH2 1 
ATOM   4005 N  N   . PHE B 1 219 ? 2.40365   -20.87013 -27.71879 1.000 30.47221 ? 219 PHE B N   1 
ATOM   4006 C  CA  . PHE B 1 219 ? 3.45205   -21.34228 -26.81985 1.000 26.06251 ? 219 PHE B CA  1 
ATOM   4007 C  C   . PHE B 1 219 ? 3.05097   -22.58300 -26.03518 1.000 30.24819 ? 219 PHE B C   1 
ATOM   4008 O  O   . PHE B 1 219 ? 3.87643   -23.12319 -25.29110 1.000 32.15958 ? 219 PHE B O   1 
ATOM   4009 C  CB  . PHE B 1 219 ? 3.85318   -20.22407 -25.84330 1.000 31.19182 ? 219 PHE B CB  1 
ATOM   4010 C  CG  . PHE B 1 219 ? 2.68804   -19.61914 -25.10026 1.000 27.40577 ? 219 PHE B CG  1 
ATOM   4011 C  CD1 . PHE B 1 219 ? 2.21045   -20.20051 -23.93313 1.000 25.10526 ? 219 PHE B CD1 1 
ATOM   4012 C  CD2 . PHE B 1 219 ? 2.06145   -18.47805 -25.58117 1.000 31.02938 ? 219 PHE B CD2 1 
ATOM   4013 C  CE1 . PHE B 1 219 ? 1.13279   -19.65146 -23.25386 1.000 25.72535 ? 219 PHE B CE1 1 
ATOM   4014 C  CE2 . PHE B 1 219 ? 0.98662   -17.92173 -24.90910 1.000 26.21081 ? 219 PHE B CE2 1 
ATOM   4015 C  CZ  . PHE B 1 219 ? 0.52085   -18.50950 -23.73982 1.000 29.33939 ? 219 PHE B CZ  1 
ATOM   4016 N  N   . LEU B 1 220 ? 1.81057   -23.03234 -26.15985 1.000 23.81393 ? 220 LEU B N   1 
ATOM   4017 C  CA  . LEU B 1 220 ? 1.38986   -24.25009 -25.49203 1.000 32.24521 ? 220 LEU B CA  1 
ATOM   4018 C  C   . LEU B 1 220 ? 1.93432   -25.46909 -26.22675 1.000 38.26568 ? 220 LEU B C   1 
ATOM   4019 O  O   . LEU B 1 220 ? 2.11796   -25.45367 -27.44763 1.000 36.24074 ? 220 LEU B O   1 
ATOM   4020 C  CB  . LEU B 1 220 ? -0.13092  -24.32259 -25.42451 1.000 31.79627 ? 220 LEU B CB  1 
ATOM   4021 C  CG  . LEU B 1 220 ? -0.82254  -23.17876 -24.69364 1.000 31.97106 ? 220 LEU B CG  1 
ATOM   4022 C  CD1 . LEU B 1 220 ? -2.32015  -23.30178 -24.89809 1.000 28.79905 ? 220 LEU B CD1 1 
ATOM   4023 C  CD2 . LEU B 1 220 ? -0.46210  -23.20069 -23.21355 1.000 29.51090 ? 220 LEU B CD2 1 
ATOM   4024 N  N   . ASN B 1 221 ? 2.18518   -26.53634 -25.47002 1.000 37.77768 ? 221 ASN B N   1 
ATOM   4025 C  CA  . ASN B 1 221 ? 2.69284   -27.78376 -26.02832 1.000 36.36595 ? 221 ASN B CA  1 
ATOM   4026 C  C   . ASN B 1 221 ? 2.03724   -28.95210 -25.29861 1.000 39.92768 ? 221 ASN B C   1 
ATOM   4027 O  O   . ASN B 1 221 ? 1.25285   -28.76712 -24.36417 1.000 38.41715 ? 221 ASN B O   1 
ATOM   4028 C  CB  . ASN B 1 221 ? 4.22236   -27.84265 -25.94325 1.000 34.00516 ? 221 ASN B CB  1 
ATOM   4029 C  CG  . ASN B 1 221 ? 4.74346   -27.64847 -24.52422 1.000 37.01988 ? 221 ASN B CG  1 
ATOM   4030 O  OD1 . ASN B 1 221 ? 4.04016   -27.90932 -23.54607 1.000 38.59824 ? 221 ASN B OD1 1 
ATOM   4031 N  ND2 . ASN B 1 221 ? 5.98909   -27.20198 -24.41007 1.000 34.07964 ? 221 ASN B ND2 1 
ATOM   4032 N  N   . ARG B 1 222 ? 2.37429   -30.16875 -25.71847 1.000 40.24958 ? 222 ARG B N   1 
ATOM   4033 C  CA  . ARG B 1 222 ? 1.77422   -31.36625 -25.14131 1.000 37.62349 ? 222 ARG B CA  1 
ATOM   4034 C  C   . ARG B 1 222 ? 2.42492   -31.81259 -23.83420 1.000 34.26657 ? 222 ARG B C   1 
ATOM   4035 O  O   . ARG B 1 222 ? 1.98332   -32.81479 -23.26157 1.000 33.86144 ? 222 ARG B O   1 
ATOM   4036 C  CB  . ARG B 1 222 ? 1.84658   -32.51374 -26.14827 1.000 35.56530 ? 222 ARG B CB  1 
ATOM   4037 C  CG  . ARG B 1 222 ? 3.25820   -33.04832 -26.35571 1.000 38.68303 ? 222 ARG B CG  1 
ATOM   4038 C  CD  . ARG B 1 222 ? 3.25429   -34.21635 -27.32544 1.000 35.69867 ? 222 ARG B CD  1 
ATOM   4039 N  NE  . ARG B 1 222 ? 3.04252   -33.75015 -28.68763 1.000 40.51313 ? 222 ARG B NE  1 
ATOM   4040 C  CZ  . ARG B 1 222 ? 2.28470   -34.37112 -29.58002 1.000 46.24685 ? 222 ARG B CZ  1 
ATOM   4041 N  NH1 . ARG B 1 222 ? 1.63236   -35.48378 -29.27662 1.000 43.10075 ? 222 ARG B NH1 1 
ATOM   4042 N  NH2 . ARG B 1 222 ? 2.16954   -33.85674 -30.80471 1.000 44.95826 ? 222 ARG B NH2 1 
ATOM   4043 N  N   . PHE B 1 223 ? 3.44258   -31.11319 -23.34454 1.000 32.76139 ? 223 PHE B N   1 
ATOM   4044 C  CA  . PHE B 1 223 ? 4.32123   -31.66670 -22.32528 1.000 34.64013 ? 223 PHE B CA  1 
ATOM   4045 C  C   . PHE B 1 223 ? 3.97075   -31.16859 -20.92302 1.000 42.63414 ? 223 PHE B C   1 
ATOM   4046 O  O   . PHE B 1 223 ? 3.08825   -30.32788 -20.72205 1.000 39.73485 ? 223 PHE B O   1 
ATOM   4047 C  CB  . PHE B 1 223 ? 5.78362   -31.34142 -22.65229 1.000 31.12556 ? 223 PHE B CB  1 
ATOM   4048 C  CG  . PHE B 1 223 ? 6.25267   -31.91393 -23.96227 1.000 37.53825 ? 223 PHE B CG  1 
ATOM   4049 C  CD1 . PHE B 1 223 ? 6.26330   -33.28581 -24.17195 1.000 33.50911 ? 223 PHE B CD1 1 
ATOM   4050 C  CD2 . PHE B 1 223 ? 6.67687   -31.07938 -24.99006 1.000 36.41872 ? 223 PHE B CD2 1 
ATOM   4051 C  CE1 . PHE B 1 223 ? 6.68296   -33.81232 -25.37921 1.000 33.80899 ? 223 PHE B CE1 1 
ATOM   4052 C  CE2 . PHE B 1 223 ? 7.10261   -31.60137 -26.19643 1.000 34.96910 ? 223 PHE B CE2 1 
ATOM   4053 C  CZ  . PHE B 1 223 ? 7.10812   -32.96930 -26.39433 1.000 36.68115 ? 223 PHE B CZ  1 
ATOM   4054 N  N   . THR B 1 224 ? 4.68097   -31.73272 -19.94270 1.000 38.03553 ? 224 THR B N   1 
ATOM   4055 C  CA  . THR B 1 224 ? 4.59335   -31.35315 -18.53913 1.000 39.36155 ? 224 THR B CA  1 
ATOM   4056 C  C   . THR B 1 224 ? 5.96568   -31.53624 -17.90978 1.000 39.39122 ? 224 THR B C   1 
ATOM   4057 O  O   . THR B 1 224 ? 6.71638   -32.43980 -18.28445 1.000 40.36275 ? 224 THR B O   1 
ATOM   4058 C  CB  . THR B 1 224 ? 3.55793   -32.18992 -17.77786 1.000 42.93287 ? 224 THR B CB  1 
ATOM   4059 O  OG1 . THR B 1 224 ? 2.28031   -32.05732 -18.40760 1.000 49.07027 ? 224 THR B OG1 1 
ATOM   4060 C  CG2 . THR B 1 224 ? 3.44375   -31.73031 -16.33583 1.000 40.53650 ? 224 THR B CG2 1 
ATOM   4061 N  N   . THR B 1 225 ? 6.29493   -30.66821 -16.96221 1.000 43.85185 ? 225 THR B N   1 
ATOM   4062 C  CA  . THR B 1 225 ? 7.53281   -30.77759 -16.21031 1.000 38.66018 ? 225 THR B CA  1 
ATOM   4063 C  C   . THR B 1 225 ? 7.20203   -31.10229 -14.75769 1.000 44.26101 ? 225 THR B C   1 
ATOM   4064 O  O   . THR B 1 225 ? 6.04536   -31.36374 -14.40216 1.000 43.40510 ? 225 THR B O   1 
ATOM   4065 C  CB  . THR B 1 225 ? 8.35197   -29.48981 -16.33409 1.000 45.36188 ? 225 THR B CB  1 
ATOM   4066 O  OG1 . THR B 1 225 ? 9.66667   -29.69765 -15.79986 1.000 42.56256 ? 225 THR B OG1 1 
ATOM   4067 C  CG2 . THR B 1 225 ? 7.67669   -28.35302 -15.57621 1.000 40.18713 ? 225 THR B CG2 1 
ATOM   4068 N  N   . THR B 1 226 ? 8.22755   -31.10854 -13.91462 1.000 43.34695 ? 226 THR B N   1 
ATOM   4069 C  CA  . THR B 1 226 ? 8.03953   -31.19031 -12.47686 1.000 46.87758 ? 226 THR B CA  1 
ATOM   4070 C  C   . THR B 1 226 ? 8.49520   -29.88790 -11.83898 1.000 41.08845 ? 226 THR B C   1 
ATOM   4071 O  O   . THR B 1 226 ? 9.27216   -29.12213 -12.42022 1.000 38.08478 ? 226 THR B O   1 
ATOM   4072 C  CB  . THR B 1 226 ? 8.81428   -32.36481 -11.86627 1.000 43.29061 ? 226 THR B CB  1 
ATOM   4073 O  OG1 . THR B 1 226 ? 10.22205  -32.12180 -11.98724 1.000 45.40935 ? 226 THR B OG1 1 
ATOM   4074 C  CG2 . THR B 1 226 ? 8.46559   -33.65464 -12.58223 1.000 48.20426 ? 226 THR B CG2 1 
ATOM   4075 N  N   . LEU B 1 227 ? 7.98541   -29.64365 -10.63022 1.000 46.12436 ? 227 LEU B N   1 
ATOM   4076 C  CA  . LEU B 1 227 ? 8.42593   -28.48734 -9.85984  1.000 38.27749 ? 227 LEU B CA  1 
ATOM   4077 C  C   . LEU B 1 227 ? 9.94182   -28.49474 -9.69992  1.000 43.67624 ? 227 LEU B C   1 
ATOM   4078 O  O   . LEU B 1 227 ? 10.61239  -27.48440 -9.94809  1.000 40.64026 ? 227 LEU B O   1 
ATOM   4079 C  CB  . LEU B 1 227 ? 7.72173   -28.48445 -8.50510  1.000 46.19216 ? 227 LEU B CB  1 
ATOM   4080 C  CG  . LEU B 1 227 ? 7.41328   -27.12679 -7.87444  1.000 48.81559 ? 227 LEU B CG  1 
ATOM   4081 C  CD1 . LEU B 1 227 ? 7.09077   -26.08962 -8.94188  1.000 39.36904 ? 227 LEU B CD1 1 
ATOM   4082 C  CD2 . LEU B 1 227 ? 6.25541   -27.26816 -6.89673  1.000 38.79005 ? 227 LEU B CD2 1 
ATOM   4083 N  N   . ASN B 1 228 ? 10.49918  -29.65062 -9.32213  1.000 43.93926 ? 228 ASN B N   1 
ATOM   4084 C  CA  . ASN B 1 228 ? 11.94600  -29.80305 -9.20339  1.000 43.47494 ? 228 ASN B CA  1 
ATOM   4085 C  C   . ASN B 1 228 ? 12.65442  -29.43188 -10.50085 1.000 40.45973 ? 228 ASN B C   1 
ATOM   4086 O  O   . ASN B 1 228 ? 13.56364  -28.59492 -10.50728 1.000 43.86227 ? 228 ASN B O   1 
ATOM   4087 C  CB  . ASN B 1 228 ? 12.28508  -31.24088 -8.80373  1.000 46.62178 ? 228 ASN B CB  1 
ATOM   4088 C  CG  . ASN B 1 228 ? 12.65005  -31.36848 -7.34424  1.000 55.27607 ? 228 ASN B CG  1 
ATOM   4089 O  OD1 . ASN B 1 228 ? 13.76297  -31.02834 -6.94502  1.000 58.47253 ? 228 ASN B OD1 1 
ATOM   4090 N  ND2 . ASN B 1 228 ? 11.71911  -31.86817 -6.53829  1.000 53.25613 ? 228 ASN B ND2 1 
ATOM   4091 N  N   . ASP B 1 229 ? 12.25366  -30.05929 -11.61382 1.000 44.93629 ? 229 ASP B N   1 
ATOM   4092 C  CA  . ASP B 1 229 ? 12.90476  -29.80473 -12.89727 1.000 42.72027 ? 229 ASP B CA  1 
ATOM   4093 C  C   . ASP B 1 229 ? 12.78752  -28.34083 -13.29787 1.000 45.23574 ? 229 ASP B C   1 
ATOM   4094 O  O   . ASP B 1 229 ? 13.76342  -27.73333 -13.75513 1.000 41.60928 ? 229 ASP B O   1 
ATOM   4095 C  CB  . ASP B 1 229 ? 12.29817  -30.69429 -13.98707 1.000 47.80492 ? 229 ASP B CB  1 
ATOM   4096 C  CG  . ASP B 1 229 ? 12.78228  -32.13819 -13.91736 1.000 52.29863 ? 229 ASP B CG  1 
ATOM   4097 O  OD1 . ASP B 1 229 ? 13.94108  -32.36656 -13.51384 1.000 50.23276 ? 229 ASP B OD1 1 
ATOM   4098 O  OD2 . ASP B 1 229 ? 11.99938  -33.04543 -14.28062 1.000 51.45908 ? 229 ASP B OD2 1 
ATOM   4099 N  N   . PHE B 1 230 ? 11.59762  -27.75708 -13.13852 1.000 44.31297 ? 230 PHE B N   1 
ATOM   4100 C  CA  . PHE B 1 230 ? 11.40713  -26.36724 -13.53865 1.000 41.48253 ? 230 PHE B CA  1 
ATOM   4101 C  C   . PHE B 1 230 ? 12.26128  -25.42711 -12.69538 1.000 39.45425 ? 230 PHE B C   1 
ATOM   4102 O  O   . PHE B 1 230 ? 12.94226  -24.54076 -13.22940 1.000 40.39388 ? 230 PHE B O   1 
ATOM   4103 C  CB  . PHE B 1 230 ? 9.93240   -25.98680 -13.44092 1.000 37.37670 ? 230 PHE B CB  1 
ATOM   4104 C  CG  . PHE B 1 230 ? 9.67442   -24.54708 -13.75483 1.000 36.84875 ? 230 PHE B CG  1 
ATOM   4105 C  CD1 . PHE B 1 230 ? 9.61104   -24.11515 -15.06726 1.000 37.47166 ? 230 PHE B CD1 1 
ATOM   4106 C  CD2 . PHE B 1 230 ? 9.52142   -23.61949 -12.73780 1.000 41.03501 ? 230 PHE B CD2 1 
ATOM   4107 C  CE1 . PHE B 1 230 ? 9.39263   -22.78806 -15.35839 1.000 38.47673 ? 230 PHE B CE1 1 
ATOM   4108 C  CE2 . PHE B 1 230 ? 9.30181   -22.29210 -13.02189 1.000 37.86599 ? 230 PHE B CE2 1 
ATOM   4109 C  CZ  . PHE B 1 230 ? 9.23827   -21.87360 -14.33363 1.000 37.13209 ? 230 PHE B CZ  1 
ATOM   4110 N  N   . ASN B 1 231 ? 12.24715  -25.61378 -11.37193 1.000 40.89533 ? 231 ASN B N   1 
ATOM   4111 C  CA  . ASN B 1 231 ? 12.98598  -24.71505 -10.49078 1.000 36.36840 ? 231 ASN B CA  1 
ATOM   4112 C  C   . ASN B 1 231 ? 14.48439  -24.76378 -10.75349 1.000 41.24918 ? 231 ASN B C   1 
ATOM   4113 O  O   . ASN B 1 231 ? 15.18382  -23.76861 -10.52829 1.000 44.84583 ? 231 ASN B O   1 
ATOM   4114 C  CB  . ASN B 1 231 ? 12.66600  -25.04220 -9.03540  1.000 39.90134 ? 231 ASN B CB  1 
ATOM   4115 C  CG  . ASN B 1 231 ? 11.37344  -24.39693 -8.57721  1.000 37.30170 ? 231 ASN B CG  1 
ATOM   4116 O  OD1 . ASN B 1 231 ? 11.08965  -23.25439 -8.93392  1.000 38.56626 ? 231 ASN B OD1 1 
ATOM   4117 N  ND2 . ASN B 1 231 ? 10.57432  -25.12661 -7.80504  1.000 35.04036 ? 231 ASN B ND2 1 
ATOM   4118 N  N   . LEU B 1 232 ? 14.99393  -25.89492 -11.25033 1.000 44.06579 ? 232 LEU B N   1 
ATOM   4119 C  CA  . LEU B 1 232 ? 16.38484  -25.94067 -11.69075 1.000 42.66533 ? 232 LEU B CA  1 
ATOM   4120 C  C   . LEU B 1 232 ? 16.60092  -25.06236 -12.91557 1.000 41.35908 ? 232 LEU B C   1 
ATOM   4121 O  O   . LEU B 1 232 ? 17.61838  -24.36744 -13.01637 1.000 40.31790 ? 232 LEU B O   1 
ATOM   4122 C  CB  . LEU B 1 232 ? 16.79674  -27.38308 -11.97710 1.000 44.65022 ? 232 LEU B CB  1 
ATOM   4123 C  CG  . LEU B 1 232 ? 16.78755  -28.27670 -10.73547 1.000 51.48005 ? 232 LEU B CG  1 
ATOM   4124 C  CD1 . LEU B 1 232 ? 17.14406  -29.70646 -11.09476 1.000 54.00344 ? 232 LEU B CD1 1 
ATOM   4125 C  CD2 . LEU B 1 232 ? 17.74613  -27.72379 -9.69178  1.000 49.69775 ? 232 LEU B CD2 1 
ATOM   4126 N  N   . VAL B 1 233 ? 15.64811  -25.07206 -13.84921 1.000 43.98085 ? 233 VAL B N   1 
ATOM   4127 C  CA  . VAL B 1 233 ? 15.70874  -24.16357 -14.99142 1.000 44.86201 ? 233 VAL B CA  1 
ATOM   4128 C  C   . VAL B 1 233 ? 15.54852  -22.72158 -14.52657 1.000 42.23202 ? 233 VAL B C   1 
ATOM   4129 O  O   . VAL B 1 233 ? 16.29615  -21.82879 -14.94356 1.000 43.66971 ? 233 VAL B O   1 
ATOM   4130 C  CB  . VAL B 1 233 ? 14.63349  -24.53656 -16.03132 1.000 48.88805 ? 233 VAL B CB  1 
ATOM   4131 C  CG1 . VAL B 1 233 ? 14.84397  -23.75720 -17.32127 1.000 46.04977 ? 233 VAL B CG1 1 
ATOM   4132 C  CG2 . VAL B 1 233 ? 14.62655  -26.03516 -16.29235 1.000 48.91176 ? 233 VAL B CG2 1 
ATOM   4133 N  N   . ALA B 1 234 ? 14.56272  -22.47678 -13.65778 1.000 44.25339 ? 234 ALA B N   1 
ATOM   4134 C  CA  . ALA B 1 234 ? 14.29985  -21.12405 -13.17120 1.000 44.24004 ? 234 ALA B CA  1 
ATOM   4135 C  C   . ALA B 1 234 ? 15.53705  -20.52157 -12.51706 1.000 42.12447 ? 234 ALA B C   1 
ATOM   4136 O  O   . ALA B 1 234 ? 15.94084  -19.39793 -12.84598 1.000 39.18240 ? 234 ALA B O   1 
ATOM   4137 C  CB  . ALA B 1 234 ? 13.12644  -21.14227 -12.18935 1.000 39.43235 ? 234 ALA B CB  1 
ATOM   4138 N  N   . MET B 1 235 ? 16.14967  -21.26271 -11.58321 1.000 43.50573 ? 235 MET B N   1 
ATOM   4139 C  CA  . MET B 1 235 ? 17.37952  -20.81102 -10.93698 1.000 40.12152 ? 235 MET B CA  1 
ATOM   4140 C  C   . MET B 1 235 ? 18.42447  -20.39692 -11.96083 1.000 37.24121 ? 235 MET B C   1 
ATOM   4141 O  O   . MET B 1 235 ? 19.08730  -19.36681 -11.80104 1.000 39.52584 ? 235 MET B O   1 
ATOM   4142 C  CB  . MET B 1 235 ? 17.93111  -21.91409 -10.02955 1.000 39.65466 ? 235 MET B CB  1 
ATOM   4143 N  N   . LYS B 1 236 ? 18.56722  -21.17772 -13.03715 1.000 44.55612 ? 236 LYS B N   1 
ATOM   4144 C  CA  . LYS B 1 236 ? 19.55956  -20.86278 -14.06123 1.000 39.83385 ? 236 LYS B CA  1 
ATOM   4145 C  C   . LYS B 1 236 ? 19.28908  -19.51876 -14.72070 1.000 39.01267 ? 236 LYS B C   1 
ATOM   4146 O  O   . LYS B 1 236 ? 20.23071  -18.79647 -15.06460 1.000 36.26576 ? 236 LYS B O   1 
ATOM   4147 C  CB  . LYS B 1 236 ? 19.59047  -21.96894 -15.11726 1.000 42.77558 ? 236 LYS B CB  1 
ATOM   4148 N  N   . TYR B 1 237 ? 18.01679  -19.16281 -14.90289 1.000 41.64190 ? 237 TYR B N   1 
ATOM   4149 C  CA  . TYR B 1 237 ? 17.64092  -17.94894 -15.61553 1.000 41.70701 ? 237 TYR B CA  1 
ATOM   4150 C  C   . TYR B 1 237 ? 17.25052  -16.81094 -14.67716 1.000 40.56797 ? 237 TYR B C   1 
ATOM   4151 O  O   . TYR B 1 237 ? 16.57251  -15.87053 -15.10926 1.000 36.33538 ? 237 TYR B O   1 
ATOM   4152 C  CB  . TYR B 1 237 ? 16.50323  -18.24853 -16.59352 1.000 38.64371 ? 237 TYR B CB  1 
ATOM   4153 C  CG  . TYR B 1 237 ? 16.93466  -19.10248 -17.76336 1.000 45.37752 ? 237 TYR B CG  1 
ATOM   4154 C  CD1 . TYR B 1 237 ? 17.49244  -18.52605 -18.89892 1.000 42.77337 ? 237 TYR B CD1 1 
ATOM   4155 C  CD2 . TYR B 1 237 ? 16.79552  -20.48412 -17.73059 1.000 46.40050 ? 237 TYR B CD2 1 
ATOM   4156 C  CE1 . TYR B 1 237 ? 17.90043  -19.30149 -19.96917 1.000 42.28442 ? 237 TYR B CE1 1 
ATOM   4157 C  CE2 . TYR B 1 237 ? 17.19751  -21.26820 -18.79846 1.000 46.62885 ? 237 TYR B CE2 1 
ATOM   4158 C  CZ  . TYR B 1 237 ? 17.75086  -20.67109 -19.91424 1.000 45.68017 ? 237 TYR B CZ  1 
ATOM   4159 O  OH  . TYR B 1 237 ? 18.15654  -21.44810 -20.97818 1.000 50.64457 ? 237 TYR B OH  1 
ATOM   4160 N  N   . ASN B 1 238 ? 17.68027  -16.87149 -13.41288 1.000 40.32147 ? 238 ASN B N   1 
ATOM   4161 C  CA  . ASN B 1 238 ? 17.33145  -15.87175 -12.39953 1.000 36.00897 ? 238 ASN B CA  1 
ATOM   4162 C  C   . ASN B 1 238 ? 15.82002  -15.64130 -12.34858 1.000 34.54540 ? 238 ASN B C   1 
ATOM   4163 O  O   . ASN B 1 238 ? 15.32673  -14.51726 -12.42914 1.000 31.24729 ? 238 ASN B O   1 
ATOM   4164 C  CB  . ASN B 1 238 ? 18.08246  -14.56186 -12.63431 1.000 36.26012 ? 238 ASN B CB  1 
ATOM   4165 C  CG  . ASN B 1 238 ? 19.49189  -14.59912 -12.07884 1.000 47.11820 ? 238 ASN B CG  1 
ATOM   4166 O  OD1 . ASN B 1 238 ? 19.92301  -15.61080 -11.52062 1.000 50.14514 ? 238 ASN B OD1 1 
ATOM   4167 N  ND2 . ASN B 1 238 ? 20.21885  -13.50011 -12.22950 1.000 42.02930 ? 238 ASN B ND2 1 
ATOM   4168 N  N   . TYR B 1 239 ? 15.08488  -16.73512 -12.23573 1.000 32.54595 ? 239 TYR B N   1 
ATOM   4169 C  CA  . TYR B 1 239 ? 13.65469  -16.71055 -11.98910 1.000 33.18573 ? 239 TYR B CA  1 
ATOM   4170 C  C   . TYR B 1 239 ? 13.40564  -17.14518 -10.55322 1.000 34.47070 ? 239 TYR B C   1 
ATOM   4171 O  O   . TYR B 1 239 ? 14.05569  -18.07417 -10.05882 1.000 32.99287 ? 239 TYR B O   1 
ATOM   4172 C  CB  . TYR B 1 239 ? 12.91074  -17.63795 -12.95478 1.000 30.27555 ? 239 TYR B CB  1 
ATOM   4173 C  CG  . TYR B 1 239 ? 12.35585  -16.95603 -14.18007 1.000 29.88752 ? 239 TYR B CG  1 
ATOM   4174 C  CD1 . TYR B 1 239 ? 13.18845  -16.29034 -15.07183 1.000 30.70395 ? 239 TYR B CD1 1 
ATOM   4175 C  CD2 . TYR B 1 239 ? 10.99104  -16.99429 -14.45644 1.000 28.40194 ? 239 TYR B CD2 1 
ATOM   4176 C  CE1 . TYR B 1 239 ? 12.67543  -15.67031 -16.19940 1.000 26.90217 ? 239 TYR B CE1 1 
ATOM   4177 C  CE2 . TYR B 1 239 ? 10.47197  -16.37927 -15.57709 1.000 24.13357 ? 239 TYR B CE2 1 
ATOM   4178 C  CZ  . TYR B 1 239 ? 11.30739  -15.72306 -16.44014 1.000 26.80482 ? 239 TYR B CZ  1 
ATOM   4179 O  OH  . TYR B 1 239 ? 10.77855  -15.11634 -17.55291 1.000 29.71018 ? 239 TYR B OH  1 
ATOM   4180 N  N   . GLU B 1 240 ? 12.47990  -16.46123 -9.88516  1.000 30.43886 ? 240 GLU B N   1 
ATOM   4181 C  CA  . GLU B 1 240 ? 12.10971  -16.85107 -8.53491  1.000 30.39292 ? 240 GLU B CA  1 
ATOM   4182 C  C   . GLU B 1 240 ? 11.65239  -18.30617 -8.53138  1.000 34.20643 ? 240 GLU B C   1 
ATOM   4183 O  O   . GLU B 1 240 ? 11.01428  -18.75745 -9.48836  1.000 30.95092 ? 240 GLU B O   1 
ATOM   4184 C  CB  . GLU B 1 240 ? 10.99757  -15.95078 -7.99185  1.000 28.01471 ? 240 GLU B CB  1 
ATOM   4185 C  CG  . GLU B 1 240 ? 11.48659  -14.59736 -7.53206  1.000 32.45396 ? 240 GLU B CG  1 
ATOM   4186 C  CD  . GLU B 1 240 ? 12.44182  -14.70165 -6.35030  1.000 35.12799 ? 240 GLU B CD  1 
ATOM   4187 O  OE1 . GLU B 1 240 ? 12.06979  -15.32498 -5.33441  1.000 37.65869 ? 240 GLU B OE1 1 
ATOM   4188 O  OE2 . GLU B 1 240 ? 13.56249  -14.16780 -6.44567  1.000 34.84072 ? 240 GLU B OE2 1 
ATOM   4189 N  N   . PRO B 1 241 ? 11.98630  -19.07491 -7.49657  1.000 36.63699 ? 241 PRO B N   1 
ATOM   4190 C  CA  . PRO B 1 241 ? 11.46931  -20.44293 -7.41185  1.000 37.59882 ? 241 PRO B CA  1 
ATOM   4191 C  C   . PRO B 1 241 ? 9.95313   -20.45362 -7.29415  1.000 35.42059 ? 241 PRO B C   1 
ATOM   4192 O  O   . PRO B 1 241 ? 9.34500   -19.56199 -6.70019  1.000 37.55311 ? 241 PRO B O   1 
ATOM   4193 C  CB  . PRO B 1 241 ? 12.14123  -21.00714 -6.15080  1.000 40.36751 ? 241 PRO B CB  1 
ATOM   4194 C  CG  . PRO B 1 241 ? 12.67981  -19.81853 -5.41709  1.000 43.08224 ? 241 PRO B CG  1 
ATOM   4195 C  CD  . PRO B 1 241 ? 12.98711  -18.79090 -6.45644  1.000 35.59446 ? 241 PRO B CD  1 
ATOM   4196 N  N   . LEU B 1 242 ? 9.34295   -21.47468 -7.88830  1.000 34.20181 ? 242 LEU B N   1 
ATOM   4197 C  CA  . LEU B 1 242 ? 7.90087   -21.66566 -7.84619  1.000 32.19101 ? 242 LEU B CA  1 
ATOM   4198 C  C   . LEU B 1 242 ? 7.56752   -22.62540 -6.71303  1.000 34.02634 ? 242 LEU B C   1 
ATOM   4199 O  O   . LEU B 1 242 ? 8.14164   -23.71648 -6.63020  1.000 36.62622 ? 242 LEU B O   1 
ATOM   4200 C  CB  . LEU B 1 242 ? 7.38443   -22.21193 -9.17860  1.000 33.60836 ? 242 LEU B CB  1 
ATOM   4201 C  CG  . LEU B 1 242 ? 5.86398   -22.21757 -9.39038  1.000 37.49473 ? 242 LEU B CG  1 
ATOM   4202 C  CD1 . LEU B 1 242 ? 5.34371   -20.81304 -9.70044  1.000 26.61337 ? 242 LEU B CD1 1 
ATOM   4203 C  CD2 . LEU B 1 242 ? 5.48310   -23.18349 -10.49872 1.000 39.43354 ? 242 LEU B CD2 1 
ATOM   4204 N  N   . THR B 1 243 ? 6.65811   -22.21719 -5.83645  1.000 32.19756 ? 243 THR B N   1 
ATOM   4205 C  CA  . THR B 1 243 ? 6.29733   -23.02498 -4.68233  1.000 36.47586 ? 243 THR B CA  1 
ATOM   4206 C  C   . THR B 1 243 ? 4.93486   -23.67187 -4.88599  1.000 35.11375 ? 243 THR B C   1 
ATOM   4207 O  O   . THR B 1 243 ? 4.19641   -23.35512 -5.82182  1.000 36.16987 ? 243 THR B O   1 
ATOM   4208 C  CB  . THR B 1 243 ? 6.29813   -22.18291 -3.40198  1.000 36.26188 ? 243 THR B CB  1 
ATOM   4209 O  OG1 . THR B 1 243 ? 5.22952   -21.22981 -3.44841  1.000 33.33354 ? 243 THR B OG1 1 
ATOM   4210 C  CG2 . THR B 1 243 ? 7.63007   -21.45284 -3.24941  1.000 35.60181 ? 243 THR B CG2 1 
ATOM   4211 N  N   . GLN B 1 244 ? 4.60608   -24.59660 -3.98178  1.000 36.26448 ? 244 GLN B N   1 
ATOM   4212 C  CA  . GLN B 1 244 ? 3.29789   -25.23966 -4.02991  1.000 36.84504 ? 244 GLN B CA  1 
ATOM   4213 C  C   . GLN B 1 244 ? 2.16873   -24.24796 -3.76212  1.000 40.05745 ? 244 GLN B C   1 
ATOM   4214 O  O   . GLN B 1 244 ? 1.05789   -24.41883 -4.28583  1.000 42.06839 ? 244 GLN B O   1 
ATOM   4215 C  CB  . GLN B 1 244 ? 3.24629   -26.39947 -3.03390  1.000 39.07982 ? 244 GLN B CB  1 
ATOM   4216 C  CG  . GLN B 1 244 ? 1.97959   -27.22172 -3.13000  1.000 39.33844 ? 244 GLN B CG  1 
ATOM   4217 C  CD  . GLN B 1 244 ? 1.72803   -27.69658 -4.54521  1.000 41.36812 ? 244 GLN B CD  1 
ATOM   4218 O  OE1 . GLN B 1 244 ? 2.62329   -28.23232 -5.20072  1.000 42.98273 ? 244 GLN B OE1 1 
ATOM   4219 N  NE2 . GLN B 1 244 ? 0.51135   -27.48563 -5.03301  1.000 44.51753 ? 244 GLN B NE2 1 
ATOM   4220 N  N   . ASP B 1 245 ? 2.42050   -23.20990 -2.95660  1.000 36.99368 ? 245 ASP B N   1 
ATOM   4221 C  CA  . ASP B 1 245 ? 1.39929   -22.17891 -2.77528  1.000 34.66040 ? 245 ASP B CA  1 
ATOM   4222 C  C   . ASP B 1 245 ? 1.13749   -21.44368 -4.08434  1.000 36.83373 ? 245 ASP B C   1 
ATOM   4223 O  O   . ASP B 1 245 ? -0.00677  -21.08727 -4.39195  1.000 32.56567 ? 245 ASP B O   1 
ATOM   4224 C  CB  . ASP B 1 245 ? 1.82330   -21.19547 -1.68524  1.000 36.78489 ? 245 ASP B CB  1 
ATOM   4225 N  N   . HIS B 1 246 ? 2.19078   -21.22822 -4.87326  1.000 33.53544 ? 246 HIS B N   1 
ATOM   4226 C  CA  . HIS B 1 246 ? 2.04139   -20.58440 -6.17382  1.000 34.78271 ? 246 HIS B CA  1 
ATOM   4227 C  C   . HIS B 1 246 ? 1.15115   -21.40869 -7.09530  1.000 35.91893 ? 246 HIS B C   1 
ATOM   4228 O  O   . HIS B 1 246 ? 0.22495   -20.87975 -7.72114  1.000 32.53436 ? 246 HIS B O   1 
ATOM   4229 C  CB  . HIS B 1 246 ? 3.41754   -20.37185 -6.79952  1.000 30.42198 ? 246 HIS B CB  1 
ATOM   4230 C  CG  . HIS B 1 246 ? 4.22459   -19.29554 -6.14193  1.000 33.57082 ? 246 HIS B CG  1 
ATOM   4231 N  ND1 . HIS B 1 246 ? 5.59168   -19.19271 -6.29372  1.000 32.19143 ? 246 HIS B ND1 1 
ATOM   4232 C  CD2 . HIS B 1 246 ? 3.85709   -18.26608 -5.34327  1.000 30.25503 ? 246 HIS B CD2 1 
ATOM   4233 C  CE1 . HIS B 1 246 ? 6.03051   -18.14606 -5.61850  1.000 28.23381 ? 246 HIS B CE1 1 
ATOM   4234 N  NE2 . HIS B 1 246 ? 4.99819   -17.56552 -5.03484  1.000 28.99479 ? 246 HIS B NE2 1 
ATOM   4235 N  N   . VAL B 1 247 ? 1.41471   -22.71571 -7.18067  1.000 35.97216 ? 247 VAL B N   1 
ATOM   4236 C  CA  . VAL B 1 247 ? 0.61212   -23.58940 -8.03329  1.000 33.10028 ? 247 VAL B CA  1 
ATOM   4237 C  C   . VAL B 1 247 ? -0.84886  -23.56771 -7.60275  1.000 33.16986 ? 247 VAL B C   1 
ATOM   4238 O  O   . VAL B 1 247 ? -1.75377  -23.52141 -8.44130  1.000 38.91784 ? 247 VAL B O   1 
ATOM   4239 C  CB  . VAL B 1 247 ? 1.19371   -25.01713 -8.02376  1.000 34.64401 ? 247 VAL B CB  1 
ATOM   4240 C  CG1 . VAL B 1 247 ? 0.24517   -26.00055 -8.71072  1.000 30.85363 ? 247 VAL B CG1 1 
ATOM   4241 C  CG2 . VAL B 1 247 ? 2.55861   -25.02740 -8.68364  1.000 33.60807 ? 247 VAL B CG2 1 
ATOM   4242 N  N   . ASP B 1 248 ? -1.10640  -23.58584 -6.29032  1.000 39.10689 ? 248 ASP B N   1 
ATOM   4243 C  CA  . ASP B 1 248 ? -2.48764  -23.54680 -5.81123  1.000 32.96458 ? 248 ASP B CA  1 
ATOM   4244 C  C   . ASP B 1 248 ? -3.16316  -22.23192 -6.17555  1.000 35.28357 ? 248 ASP B C   1 
ATOM   4245 O  O   . ASP B 1 248 ? -4.35069  -22.20972 -6.52311  1.000 39.69098 ? 248 ASP B O   1 
ATOM   4246 C  CB  . ASP B 1 248 ? -2.53714  -23.74608 -4.29624  1.000 41.15461 ? 248 ASP B CB  1 
ATOM   4247 C  CG  . ASP B 1 248 ? -1.94143  -25.06614 -3.85294  1.000 46.36545 ? 248 ASP B CG  1 
ATOM   4248 O  OD1 . ASP B 1 248 ? -1.86127  -26.00165 -4.67499  1.000 49.50337 ? 248 ASP B OD1 1 
ATOM   4249 O  OD2 . ASP B 1 248 ? -1.55811  -25.16311 -2.67025  1.000 48.99525 ? 248 ASP B OD2 1 
ATOM   4250 N  N   . ILE B 1 249 ? -2.42474  -21.12442 -6.08509  1.000 35.49720 ? 249 ILE B N   1 
ATOM   4251 C  CA  . ILE B 1 249 ? -2.98690  -19.81495 -6.40576  1.000 35.28152 ? 249 ILE B CA  1 
ATOM   4252 C  C   . ILE B 1 249 ? -3.37241  -19.74493 -7.88129  1.000 35.85749 ? 249 ILE B C   1 
ATOM   4253 O  O   . ILE B 1 249 ? -4.39257  -19.14753 -8.24338  1.000 37.37467 ? 249 ILE B O   1 
ATOM   4254 C  CB  . ILE B 1 249 ? -1.98697  -18.71235 -6.00794  1.000 34.39009 ? 249 ILE B CB  1 
ATOM   4255 C  CG1 . ILE B 1 249 ? -1.89678  -18.62220 -4.48280  1.000 41.94481 ? 249 ILE B CG1 1 
ATOM   4256 C  CG2 . ILE B 1 249 ? -2.39097  -17.37575 -6.58034  1.000 37.75752 ? 249 ILE B CG2 1 
ATOM   4257 C  CD1 . ILE B 1 249 ? -0.66111  -17.89157 -3.97793  1.000 42.53703 ? 249 ILE B CD1 1 
ATOM   4258 N  N   . LEU B 1 250 ? -2.58127  -20.37459 -8.75171  1.000 33.59355 ? 250 LEU B N   1 
ATOM   4259 C  CA  . LEU B 1 250 ? -2.90726  -20.46669 -10.17103 1.000 32.19483 ? 250 LEU B CA  1 
ATOM   4260 C  C   . LEU B 1 250 ? -4.01229  -21.47372 -10.45971 1.000 38.00026 ? 250 LEU B C   1 
ATOM   4261 O  O   . LEU B 1 250 ? -4.41238  -21.61244 -11.62326 1.000 37.85808 ? 250 LEU B O   1 
ATOM   4262 C  CB  . LEU B 1 250 ? -1.65636  -20.83693 -10.97645 1.000 31.51360 ? 250 LEU B CB  1 
ATOM   4263 C  CG  . LEU B 1 250 ? -0.56860  -19.77004 -11.01394 1.000 26.33887 ? 250 LEU B CG  1 
ATOM   4264 C  CD1 . LEU B 1 250 ? 0.76900   -20.34386 -11.46795 1.000 20.54509 ? 250 LEU B CD1 1 
ATOM   4265 C  CD2 . LEU B 1 250 ? -1.01316  -18.63063 -11.91156 1.000 25.81654 ? 250 LEU B CD2 1 
ATOM   4266 N  N   . GLY B 1 251 ? -4.50482  -22.17319 -9.43639  1.000 39.17206 ? 251 GLY B N   1 
ATOM   4267 C  CA  . GLY B 1 251 ? -5.53740  -23.17092 -9.59108  1.000 35.72720 ? 251 GLY B CA  1 
ATOM   4268 C  C   . GLY B 1 251 ? -6.71722  -22.74273 -10.44247 1.000 36.88648 ? 251 GLY B C   1 
ATOM   4269 O  O   . GLY B 1 251 ? -7.06443  -23.40781 -11.42327 1.000 37.86626 ? 251 GLY B O   1 
ATOM   4270 N  N   . PRO B 1 252 ? -7.37230  -21.63430 -10.07552 1.000 39.70962 ? 252 PRO B N   1 
ATOM   4271 C  CA  . PRO B 1 252 ? -8.53396  -21.18356 -10.86121 1.000 31.39295 ? 252 PRO B CA  1 
ATOM   4272 C  C   . PRO B 1 252 ? -8.23486  -20.99254 -12.33661 1.000 36.79362 ? 252 PRO B C   1 
ATOM   4273 O  O   . PRO B 1 252 ? -9.04057  -21.39008 -13.18731 1.000 37.00147 ? 252 PRO B O   1 
ATOM   4274 C  CB  . PRO B 1 252 ? -8.90643  -19.86078 -10.18198 1.000 33.69344 ? 252 PRO B CB  1 
ATOM   4275 C  CG  . PRO B 1 252 ? -8.47620  -20.04033 -8.78102  1.000 32.08010 ? 252 PRO B CG  1 
ATOM   4276 C  CD  . PRO B 1 252 ? -7.20120  -20.82989 -8.85160  1.000 39.11554 ? 252 PRO B CD  1 
ATOM   4277 N  N   . LEU B 1 253 ? -7.08541  -20.40051 -12.66315 1.000 34.00863 ? 253 LEU B N   1 
ATOM   4278 C  CA  . LEU B 1 253 ? -6.73740  -20.17496 -14.06239 1.000 38.52054 ? 253 LEU B CA  1 
ATOM   4279 C  C   . LEU B 1 253 ? -6.50039  -21.49103 -14.79463 1.000 35.01805 ? 253 LEU B C   1 
ATOM   4280 O  O   . LEU B 1 253 ? -6.89025  -21.64008 -15.95760 1.000 35.04897 ? 253 LEU B O   1 
ATOM   4281 C  CB  . LEU B 1 253 ? -5.50788  -19.27249 -14.14318 1.000 33.49890 ? 253 LEU B CB  1 
ATOM   4282 C  CG  . LEU B 1 253 ? -5.72922  -17.83975 -13.63731 1.000 29.16557 ? 253 LEU B CG  1 
ATOM   4283 C  CD1 . LEU B 1 253 ? -4.43154  -17.03995 -13.70112 1.000 27.98290 ? 253 LEU B CD1 1 
ATOM   4284 C  CD2 . LEU B 1 253 ? -6.82653  -17.15608 -14.45102 1.000 29.97052 ? 253 LEU B CD2 1 
ATOM   4285 N  N   . SER B 1 254 ? -5.86371  -22.45552 -14.12578 1.000 36.66347 ? 254 SER B N   1 
ATOM   4286 C  CA  . SER B 1 254 ? -5.69852  -23.78462 -14.70579 1.000 36.32161 ? 254 SER B CA  1 
ATOM   4287 C  C   . SER B 1 254 ? -7.04694  -24.43433 -14.98223 1.000 36.16835 ? 254 SER B C   1 
ATOM   4288 O  O   . SER B 1 254 ? -7.23110  -25.08947 -16.01650 1.000 37.62030 ? 254 SER B O   1 
ATOM   4289 C  CB  . SER B 1 254 ? -4.86479  -24.66202 -13.77188 1.000 34.33816 ? 254 SER B CB  1 
ATOM   4290 O  OG  . SER B 1 254 ? -5.00460  -26.03137 -14.09803 1.000 37.29662 ? 254 SER B OG  1 
ATOM   4291 N  N   . ALA B 1 255 ? -8.00466  -24.26004 -14.06823 1.000 39.29982 ? 255 ALA B N   1 
ATOM   4292 C  CA  . ALA B 1 255 ? -9.33897  -24.81507 -14.27285 1.000 37.74705 ? 255 ALA B CA  1 
ATOM   4293 C  C   . ALA B 1 255 ? -10.04078 -24.15692 -15.45542 1.000 39.63786 ? 255 ALA B C   1 
ATOM   4294 O  O   . ALA B 1 255 ? -10.67414 -24.84140 -16.26800 1.000 37.87958 ? 255 ALA B O   1 
ATOM   4295 C  CB  . ALA B 1 255 ? -10.17079 -24.65882 -12.99978 1.000 42.80528 ? 255 ALA B CB  1 
ATOM   4296 N  N   . GLN B 1 256 ? -9.93413  -22.83239 -15.57768 1.000 35.45917 ? 256 GLN B N   1 
ATOM   4297 C  CA  . GLN B 1 256 ? -10.68410 -22.13449 -16.61757 1.000 37.66989 ? 256 GLN B CA  1 
ATOM   4298 C  C   . GLN B 1 256 ? -10.11726 -22.39359 -18.00832 1.000 36.83094 ? 256 GLN B C   1 
ATOM   4299 O  O   . GLN B 1 256 ? -10.87137 -22.42972 -18.98803 1.000 42.35155 ? 256 GLN B O   1 
ATOM   4300 C  CB  . GLN B 1 256 ? -10.70525 -20.63674 -16.32643 1.000 38.70940 ? 256 GLN B CB  1 
ATOM   4301 C  CG  . GLN B 1 256 ? -11.37551 -19.81643 -17.40196 1.000 37.98065 ? 256 GLN B CG  1 
ATOM   4302 C  CD  . GLN B 1 256 ? -11.17457 -18.33197 -17.20047 1.000 43.41667 ? 256 GLN B CD  1 
ATOM   4303 O  OE1 . GLN B 1 256 ? -10.77260 -17.89067 -16.12286 1.000 44.19740 ? 256 GLN B OE1 1 
ATOM   4304 N  NE2 . GLN B 1 256 ? -11.44822 -17.55047 -18.24053 1.000 47.17781 ? 256 GLN B NE2 1 
ATOM   4305 N  N   . THR B 1 257 ? -8.80682  -22.58140 -18.12276 1.000 32.51596 ? 257 THR B N   1 
ATOM   4306 C  CA  . THR B 1 257 ? -8.18718  -22.74369 -19.42785 1.000 34.94433 ? 257 THR B CA  1 
ATOM   4307 C  C   . THR B 1 257 ? -7.94211  -24.19474 -19.81441 1.000 32.97877 ? 257 THR B C   1 
ATOM   4308 O  O   . THR B 1 257 ? -7.78684  -24.47889 -21.00316 1.000 28.82625 ? 257 THR B O   1 
ATOM   4309 C  CB  . THR B 1 257 ? -6.85384  -21.99389 -19.47662 1.000 33.87583 ? 257 THR B CB  1 
ATOM   4310 O  OG1 . THR B 1 257 ? -6.01066  -22.46095 -18.41591 1.000 38.26711 ? 257 THR B OG1 1 
ATOM   4311 C  CG2 . THR B 1 257 ? -7.08207  -20.50001 -19.33401 1.000 33.78555 ? 257 THR B CG2 1 
ATOM   4312 N  N   . GLY B 1 258 ? -7.90263  -25.11268 -18.85493 1.000 34.24541 ? 258 GLY B N   1 
ATOM   4313 C  CA  . GLY B 1 258 ? -7.55715  -26.48339 -19.16024 1.000 36.22930 ? 258 GLY B CA  1 
ATOM   4314 C  C   . GLY B 1 258 ? -6.07293  -26.74724 -19.27194 1.000 38.01811 ? 258 GLY B C   1 
ATOM   4315 O  O   . GLY B 1 258 ? -5.68256  -27.83912 -19.70086 1.000 39.47607 ? 258 GLY B O   1 
ATOM   4316 N  N   . ILE B 1 259 ? -5.23453  -25.78325 -18.90492 1.000 36.40600 ? 259 ILE B N   1 
ATOM   4317 C  CA  . ILE B 1 259 ? -3.78646  -25.93209 -18.91715 1.000 38.39136 ? 259 ILE B CA  1 
ATOM   4318 C  C   . ILE B 1 259 ? -3.33621  -26.04634 -17.46717 1.000 37.96991 ? 259 ILE B C   1 
ATOM   4319 O  O   . ILE B 1 259 ? -3.43180  -25.07921 -16.70275 1.000 39.64661 ? 259 ILE B O   1 
ATOM   4320 C  CB  . ILE B 1 259 ? -3.09804  -24.75321 -19.61701 1.000 35.18539 ? 259 ILE B CB  1 
ATOM   4321 C  CG1 . ILE B 1 259 ? -3.88545  -24.32314 -20.85917 1.000 32.62219 ? 259 ILE B CG1 1 
ATOM   4322 C  CG2 . ILE B 1 259 ? -1.66530  -25.11902 -19.97661 1.000 34.83834 ? 259 ILE B CG2 1 
ATOM   4323 C  CD1 . ILE B 1 259 ? -3.81665  -25.31235 -22.00804 1.000 38.51479 ? 259 ILE B CD1 1 
ATOM   4324 N  N   . ALA B 1 260 ? -2.84927  -27.22026 -17.07938 1.000 38.54808 ? 260 ALA B N   1 
ATOM   4325 C  CA  . ALA B 1 260 ? -2.33987  -27.39612 -15.72747 1.000 35.82672 ? 260 ALA B CA  1 
ATOM   4326 C  C   . ALA B 1 260 ? -1.07342  -26.57238 -15.53707 1.000 34.99569 ? 260 ALA B C   1 
ATOM   4327 O  O   . ALA B 1 260 ? -0.34694  -26.28860 -16.49303 1.000 34.68548 ? 260 ALA B O   1 
ATOM   4328 C  CB  . ALA B 1 260 ? -2.05429  -28.87223 -15.44384 1.000 34.59625 ? 260 ALA B CB  1 
ATOM   4329 N  N   . VAL B 1 261 ? -0.81207  -26.18990 -14.28403 1.000 30.18687 ? 261 VAL B N   1 
ATOM   4330 C  CA  . VAL B 1 261 ? 0.29424   -25.27839 -14.00136 1.000 30.26710 ? 261 VAL B CA  1 
ATOM   4331 C  C   . VAL B 1 261 ? 1.60001   -25.83275 -14.55561 1.000 30.85705 ? 261 VAL B C   1 
ATOM   4332 O  O   . VAL B 1 261 ? 2.36670   -25.12075 -15.21326 1.000 32.32342 ? 261 VAL B O   1 
ATOM   4333 C  CB  . VAL B 1 261 ? 0.39151   -24.99633 -12.49107 1.000 31.00034 ? 261 VAL B CB  1 
ATOM   4334 C  CG1 . VAL B 1 261 ? 1.63841   -24.18197 -12.18935 1.000 26.25009 ? 261 VAL B CG1 1 
ATOM   4335 C  CG2 . VAL B 1 261 ? -0.83613  -24.25454 -12.01719 1.000 27.22114 ? 261 VAL B CG2 1 
ATOM   4336 N  N   . LEU B 1 262 ? 1.86551   -27.11757 -14.31861 1.000 31.93926 ? 262 LEU B N   1 
ATOM   4337 C  CA  . LEU B 1 262 ? 3.12790   -27.68775 -14.77495 1.000 33.16128 ? 262 LEU B CA  1 
ATOM   4338 C  C   . LEU B 1 262 ? 3.15303   -27.89233 -16.28677 1.000 36.50666 ? 262 LEU B C   1 
ATOM   4339 O  O   . LEU B 1 262 ? 4.24421   -27.98887 -16.85864 1.000 36.86637 ? 262 LEU B O   1 
ATOM   4340 C  CB  . LEU B 1 262 ? 3.42088   -28.99634 -14.03310 1.000 33.98199 ? 262 LEU B CB  1 
ATOM   4341 C  CG  . LEU B 1 262 ? 3.66543   -28.83880 -12.52380 1.000 35.43031 ? 262 LEU B CG  1 
ATOM   4342 C  CD1 . LEU B 1 262 ? 2.35944   -28.82926 -11.73080 1.000 37.70742 ? 262 LEU B CD1 1 
ATOM   4343 C  CD2 . LEU B 1 262 ? 4.60475   -29.91009 -11.98912 1.000 43.72395 ? 262 LEU B CD2 1 
ATOM   4344 N  N   . ASP B 1 263 ? 1.98414   -27.94761 -16.94531 1.000 37.35518 ? 263 ASP B N   1 
ATOM   4345 C  CA  . ASP B 1 263 ? 1.94848   -27.76289 -18.39615 1.000 36.92909 ? 263 ASP B CA  1 
ATOM   4346 C  C   . ASP B 1 263 ? 2.46221   -26.37959 -18.76351 1.000 34.31023 ? 263 ASP B C   1 
ATOM   4347 O  O   . ASP B 1 263 ? 3.33467   -26.23210 -19.62673 1.000 34.52317 ? 263 ASP B O   1 
ATOM   4348 C  CB  . ASP B 1 263 ? 0.52838   -27.93556 -18.94679 1.000 34.42824 ? 263 ASP B CB  1 
ATOM   4349 C  CG  . ASP B 1 263 ? -0.00180  -29.34525 -18.81232 1.000 44.01604 ? 263 ASP B CG  1 
ATOM   4350 O  OD1 . ASP B 1 263 ? 0.73808   -30.23491 -18.33680 1.000 46.22967 ? 263 ASP B OD1 1 
ATOM   4351 O  OD2 . ASP B 1 263 ? -1.18125  -29.55743 -19.18370 1.000 46.62740 ? 263 ASP B OD2 1 
ATOM   4352 N  N   . MET B 1 264 ? 1.92426   -25.34505 -18.11158 1.000 30.10150 ? 264 MET B N   1 
ATOM   4353 C  CA  . MET B 1 264 ? 2.36657   -23.98824 -18.41203 1.000 29.95952 ? 264 MET B CA  1 
ATOM   4354 C  C   . MET B 1 264 ? 3.83803   -23.80372 -18.05498 1.000 33.00528 ? 264 MET B C   1 
ATOM   4355 O  O   . MET B 1 264 ? 4.57949   -23.13107 -18.78249 1.000 30.64232 ? 264 MET B O   1 
ATOM   4356 C  CB  . MET B 1 264 ? 1.48659   -22.97210 -17.68071 1.000 27.28398 ? 264 MET B CB  1 
ATOM   4357 C  CG  . MET B 1 264 ? 1.53452   -21.57415 -18.28171 1.000 25.48775 ? 264 MET B CG  1 
ATOM   4358 S  SD  . MET B 1 264 ? 0.77314   -21.49842 -19.93333 1.000 25.95964 ? 264 MET B SD  1 
ATOM   4359 C  CE  . MET B 1 264 ? -0.93401  -21.18012 -19.51487 1.000 27.83478 ? 264 MET B CE  1 
ATOM   4360 N  N   . CYS B 1 265 ? 4.29059   -24.41655 -16.95323 1.000 25.67615 ? 265 CYS B N   1 
ATOM   4361 C  CA  . CYS B 1 265 ? 5.71537   -24.35581 -16.62768 1.000 30.79981 ? 265 CYS B CA  1 
ATOM   4362 C  C   . CYS B 1 265 ? 6.55629   -24.95088 -17.74365 1.000 31.27565 ? 265 CYS B C   1 
ATOM   4363 O  O   . CYS B 1 265 ? 7.64341   -24.44754 -18.05060 1.000 35.31465 ? 265 CYS B O   1 
ATOM   4364 C  CB  . CYS B 1 265 ? 6.00137   -25.08049 -15.31556 1.000 33.06855 ? 265 CYS B CB  1 
ATOM   4365 S  SG  . CYS B 1 265 ? 5.42838   -24.21095 -13.86662 1.000 35.77708 ? 265 CYS B SG  1 
ATOM   4366 N  N   . ALA B 1 266 ? 6.06551   -26.02336 -18.36666 1.000 36.71062 ? 266 ALA B N   1 
ATOM   4367 C  CA  . ALA B 1 266 ? 6.76605   -26.58641 -19.51377 1.000 35.54271 ? 266 ALA B CA  1 
ATOM   4368 C  C   . ALA B 1 266 ? 6.81061   -25.58839 -20.66534 1.000 35.76440 ? 266 ALA B C   1 
ATOM   4369 O  O   . ALA B 1 266 ? 7.86020   -25.40167 -21.29034 1.000 34.26007 ? 266 ALA B O   1 
ATOM   4370 C  CB  . ALA B 1 266 ? 6.10047   -27.89428 -19.94186 1.000 37.50181 ? 266 ALA B CB  1 
ATOM   4371 N  N   . SER B 1 267 ? 5.68536   -24.92103 -20.94737 1.000 34.00235 ? 267 SER B N   1 
ATOM   4372 C  CA  . SER B 1 267 ? 5.70072   -23.82819 -21.91749 1.000 31.55134 ? 267 SER B CA  1 
ATOM   4373 C  C   . SER B 1 267 ? 6.71740   -22.76703 -21.52431 1.000 28.92293 ? 267 SER B C   1 
ATOM   4374 O  O   . SER B 1 267 ? 7.48269   -22.28724 -22.36476 1.000 30.48969 ? 267 SER B O   1 
ATOM   4375 C  CB  . SER B 1 267 ? 4.30964   -23.20022 -22.04780 1.000 27.78229 ? 267 SER B CB  1 
ATOM   4376 O  OG  . SER B 1 267 ? 3.33365   -24.15006 -22.43315 1.000 31.87188 ? 267 SER B OG  1 
ATOM   4377 N  N   . LEU B 1 268 ? 6.73140   -22.37738 -20.24383 1.000 30.57062 ? 268 LEU B N   1 
ATOM   4378 C  CA  . LEU B 1 268 ? 7.65862   -21.34039 -19.79393 1.000 30.09930 ? 268 LEU B CA  1 
ATOM   4379 C  C   . LEU B 1 268 ? 9.09522   -21.84141 -19.80923 1.000 29.05345 ? 268 LEU B C   1 
ATOM   4380 O  O   . LEU B 1 268 ? 10.01574  -21.10140 -20.17221 1.000 30.55112 ? 268 LEU B O   1 
ATOM   4381 C  CB  . LEU B 1 268 ? 7.27638   -20.86225 -18.39112 1.000 31.90850 ? 268 LEU B CB  1 
ATOM   4382 C  CG  . LEU B 1 268 ? 8.18314   -19.80617 -17.75271 1.000 28.81676 ? 268 LEU B CG  1 
ATOM   4383 C  CD1 . LEU B 1 268 ? 8.31784   -18.60508 -18.65776 1.000 28.97456 ? 268 LEU B CD1 1 
ATOM   4384 C  CD2 . LEU B 1 268 ? 7.64869   -19.38128 -16.40233 1.000 28.40362 ? 268 LEU B CD2 1 
ATOM   4385 N  N   . LYS B 1 269 ? 9.30390   -23.09036 -19.39750 1.000 31.90196 ? 269 LYS B N   1 
ATOM   4386 C  CA  . LYS B 1 269 ? 10.61581  -23.71388 -19.52483 1.000 35.08105 ? 269 LYS B CA  1 
ATOM   4387 C  C   . LYS B 1 269 ? 11.12326  -23.61292 -20.95949 1.000 35.95294 ? 269 LYS B C   1 
ATOM   4388 O  O   . LYS B 1 269 ? 12.25190  -23.17228 -21.20390 1.000 36.95797 ? 269 LYS B O   1 
ATOM   4389 C  CB  . LYS B 1 269 ? 10.51897  -25.17071 -19.06332 1.000 40.09858 ? 269 LYS B CB  1 
ATOM   4390 C  CG  . LYS B 1 269 ? 11.83031  -25.89016 -18.84970 1.000 47.96024 ? 269 LYS B CG  1 
ATOM   4391 C  CD  . LYS B 1 269 ? 11.56103  -27.28344 -18.29183 1.000 51.91764 ? 269 LYS B CD  1 
ATOM   4392 C  CE  . LYS B 1 269 ? 12.69751  -28.23542 -18.61525 1.000 61.60757 ? 269 LYS B CE  1 
ATOM   4393 N  NZ  . LYS B 1 269 ? 13.03278  -28.19998 -20.06979 1.000 59.74349 ? 269 LYS B NZ  1 
ATOM   4394 N  N   . GLU B 1 270 ? 10.27264  -23.97098 -21.92917 1.000 38.01617 ? 270 GLU B N   1 
ATOM   4395 C  CA  . GLU B 1 270 ? 10.67102  -23.90161 -23.33409 1.000 40.73467 ? 270 GLU B CA  1 
ATOM   4396 C  C   . GLU B 1 270 ? 10.90882  -22.46420 -23.77677 1.000 40.15586 ? 270 GLU B C   1 
ATOM   4397 O  O   . GLU B 1 270 ? 11.80968  -22.19993 -24.57994 1.000 41.62150 ? 270 GLU B O   1 
ATOM   4398 C  CB  . GLU B 1 270 ? 9.61139   -24.55826 -24.22385 1.000 44.77201 ? 270 GLU B CB  1 
ATOM   4399 C  CG  . GLU B 1 270 ? 9.34221   -26.02859 -23.91978 1.000 47.10228 ? 270 GLU B CG  1 
ATOM   4400 C  CD  . GLU B 1 270 ? 10.57388  -26.90635 -24.08270 1.000 54.40031 ? 270 GLU B CD  1 
ATOM   4401 O  OE1 . GLU B 1 270 ? 11.40382  -26.61309 -24.97151 1.000 57.92037 ? 270 GLU B OE1 1 
ATOM   4402 O  OE2 . GLU B 1 270 ? 10.71236  -27.88864 -23.31724 1.000 59.20484 ? 270 GLU B OE2 1 
ATOM   4403 N  N   . LEU B 1 271 ? 10.10452  -21.52128 -23.27674 1.000 36.08593 ? 271 LEU B N   1 
ATOM   4404 C  CA  . LEU B 1 271 ? 10.30712  -20.12258 -23.63931 1.000 33.14922 ? 271 LEU B CA  1 
ATOM   4405 C  C   . LEU B 1 271 ? 11.63289  -19.59381 -23.11580 1.000 33.37989 ? 271 LEU B C   1 
ATOM   4406 O  O   . LEU B 1 271 ? 12.26339  -18.75004 -23.76005 1.000 34.99148 ? 271 LEU B O   1 
ATOM   4407 C  CB  . LEU B 1 271 ? 9.15538   -19.26797 -23.10868 1.000 30.43408 ? 271 LEU B CB  1 
ATOM   4408 C  CG  . LEU B 1 271 ? 7.82084   -19.40396 -23.84211 1.000 32.76527 ? 271 LEU B CG  1 
ATOM   4409 C  CD1 . LEU B 1 271 ? 6.71787   -18.64121 -23.11627 1.000 33.34172 ? 271 LEU B CD1 1 
ATOM   4410 C  CD2 . LEU B 1 271 ? 7.95109   -18.90992 -25.26707 1.000 28.86818 ? 271 LEU B CD2 1 
ATOM   4411 N  N   . LEU B 1 272 ? 12.05928  -20.05344 -21.93958 1.000 38.52349 ? 272 LEU B N   1 
ATOM   4412 C  CA  . LEU B 1 272 ? 13.31688  -19.57559 -21.37605 1.000 36.46197 ? 272 LEU B CA  1 
ATOM   4413 C  C   . LEU B 1 272 ? 14.51190  -20.10002 -22.16234 1.000 36.78361 ? 272 LEU B C   1 
ATOM   4414 O  O   . LEU B 1 272 ? 15.43795  -19.34354 -22.47770 1.000 39.53122 ? 272 LEU B O   1 
ATOM   4415 C  CB  . LEU B 1 272 ? 13.41024  -19.98385 -19.90802 1.000 39.01190 ? 272 LEU B CB  1 
ATOM   4416 C  CG  . LEU B 1 272 ? 12.45722  -19.20085 -19.00360 1.000 36.74327 ? 272 LEU B CG  1 
ATOM   4417 C  CD1 . LEU B 1 272 ? 12.42382  -19.76331 -17.58923 1.000 31.07955 ? 272 LEU B CD1 1 
ATOM   4418 C  CD2 . LEU B 1 272 ? 12.86554  -17.73523 -19.00473 1.000 31.93456 ? 272 LEU B CD2 1 
ATOM   4419 N  N   . GLN B 1 273 ? 14.50266  -21.38858 -22.49908 1.000 41.82534 ? 273 GLN B N   1 
ATOM   4420 C  CA  . GLN B 1 273 ? 15.64107  -21.97706 -23.19853 1.000 43.40063 ? 273 GLN B CA  1 
ATOM   4421 C  C   . GLN B 1 273 ? 15.69875  -21.52728 -24.65457 1.000 43.72035 ? 273 GLN B C   1 
ATOM   4422 O  O   . GLN B 1 273 ? 16.77071  -21.16827 -25.15463 1.000 49.78024 ? 273 GLN B O   1 
ATOM   4423 C  CB  . GLN B 1 273 ? 15.57462  -23.50102 -23.10447 1.000 43.71505 ? 273 GLN B CB  1 
ATOM   4424 C  CG  . GLN B 1 273 ? 15.82079  -24.04998 -21.70084 1.000 39.36489 ? 273 GLN B CG  1 
ATOM   4425 C  CD  . GLN B 1 273 ? 15.05154  -25.33034 -21.42733 1.000 51.18294 ? 273 GLN B CD  1 
ATOM   4426 O  OE1 . GLN B 1 273 ? 15.28260  -26.00722 -20.42279 1.000 49.48087 ? 273 GLN B OE1 1 
ATOM   4427 N  NE2 . GLN B 1 273 ? 14.11733  -25.66188 -22.31578 1.000 52.23195 ? 273 GLN B NE2 1 
ATOM   4428 N  N   . ASN B 1 274 ? 14.55726  -21.51060 -25.34343 1.000 43.85187 ? 274 ASN B N   1 
ATOM   4429 C  CA  . ASN B 1 274 ? 14.52453  -21.28131 -26.78484 1.000 43.69060 ? 274 ASN B CA  1 
ATOM   4430 C  C   . ASN B 1 274 ? 14.13591  -19.86061 -27.17288 1.000 46.73605 ? 274 ASN B C   1 
ATOM   4431 O  O   . ASN B 1 274 ? 14.31574  -19.48562 -28.33714 1.000 47.67054 ? 274 ASN B O   1 
ATOM   4432 C  CB  . ASN B 1 274 ? 13.55305  -22.26571 -27.45283 1.000 45.39612 ? 274 ASN B CB  1 
ATOM   4433 C  CG  . ASN B 1 274 ? 13.93007  -23.71149 -27.20299 1.000 45.13333 ? 274 ASN B CG  1 
ATOM   4434 O  OD1 . ASN B 1 274 ? 15.08970  -24.09259 -27.34794 1.000 56.31546 ? 274 ASN B OD1 1 
ATOM   4435 N  ND2 . ASN B 1 274 ? 12.95826  -24.51931 -26.80828 1.000 48.55829 ? 274 ASN B ND2 1 
ATOM   4436 N  N   . GLY B 1 275 ? 13.60802  -19.06564 -26.24378 1.000 46.75332 ? 275 GLY B N   1 
ATOM   4437 C  CA  . GLY B 1 275 ? 13.14203  -17.73766 -26.58687 1.000 43.94124 ? 275 GLY B CA  1 
ATOM   4438 C  C   . GLY B 1 275 ? 11.76544  -17.75842 -27.22658 1.000 40.19453 ? 275 GLY B C   1 
ATOM   4439 O  O   . GLY B 1 275 ? 11.05826  -18.76954 -27.24692 1.000 37.19433 ? 275 GLY B O   1 
ATOM   4440 N  N   . MET B 1 276 ? 11.39145  -16.60607 -27.77326 1.000 43.83850 ? 276 MET B N   1 
ATOM   4441 C  CA  . MET B 1 276 ? 10.05782  -16.41615 -28.32591 1.000 40.52474 ? 276 MET B CA  1 
ATOM   4442 C  C   . MET B 1 276 ? 9.99287   -16.65874 -29.83089 1.000 45.41340 ? 276 MET B C   1 
ATOM   4443 O  O   . MET B 1 276 ? 8.91559   -16.51266 -30.42218 1.000 40.46097 ? 276 MET B O   1 
ATOM   4444 C  CB  . MET B 1 276 ? 9.55324   -15.00720 -27.99180 1.000 44.77501 ? 276 MET B CB  1 
ATOM   4445 C  CG  . MET B 1 276 ? 8.13182   -14.98773 -27.42856 1.000 47.32943 ? 276 MET B CG  1 
ATOM   4446 S  SD  . MET B 1 276 ? 7.73445   -13.54923 -26.40904 1.000 45.39977 ? 276 MET B SD  1 
ATOM   4447 C  CE  . MET B 1 276 ? 9.00702   -13.67074 -25.15422 1.000 37.45787 ? 276 MET B CE  1 
ATOM   4448 N  N   . ASN B 1 277 ? 11.11089  -17.03591 -30.45582 1.000 44.02225 ? 277 ASN B N   1 
ATOM   4449 C  CA  . ASN B 1 277 ? 11.14473  -17.38695 -31.87568 1.000 45.34852 ? 277 ASN B CA  1 
ATOM   4450 C  C   . ASN B 1 277 ? 10.51152  -16.29489 -32.73276 1.000 45.53168 ? 277 ASN B C   1 
ATOM   4451 O  O   . ASN B 1 277 ? 9.71890   -16.56183 -33.63900 1.000 49.28819 ? 277 ASN B O   1 
ATOM   4452 C  CB  . ASN B 1 277 ? 10.47133  -18.73710 -32.11886 1.000 50.12624 ? 277 ASN B CB  1 
ATOM   4453 C  CG  . ASN B 1 277 ? 11.22437  -19.88504 -31.47126 1.000 51.45607 ? 277 ASN B CG  1 
ATOM   4454 O  OD1 . ASN B 1 277 ? 12.45300  -19.85869 -31.37085 1.000 55.26799 ? 277 ASN B OD1 1 
ATOM   4455 N  ND2 . ASN B 1 277 ? 10.49085  -20.89920 -31.02765 1.000 55.46045 ? 277 ASN B ND2 1 
ATOM   4456 N  N   . GLY B 1 278 ? 10.84989  -15.04623 -32.42228 1.000 43.69299 ? 278 GLY B N   1 
ATOM   4457 C  CA  . GLY B 1 278 ? 10.38729  -13.91560 -33.19542 1.000 46.65466 ? 278 GLY B CA  1 
ATOM   4458 C  C   . GLY B 1 278 ? 8.92600   -13.56827 -33.03714 1.000 45.73889 ? 278 GLY B C   1 
ATOM   4459 O  O   . GLY B 1 278 ? 8.43542   -12.69677 -33.76218 1.000 53.83304 ? 278 GLY B O   1 
ATOM   4460 N  N   . ARG B 1 279 ? 8.21376   -14.20530 -32.11895 1.000 40.69271 ? 279 ARG B N   1 
ATOM   4461 C  CA  . ARG B 1 279 ? 6.80039   -13.93035 -31.91456 1.000 42.60942 ? 279 ARG B CA  1 
ATOM   4462 C  C   . ARG B 1 279 ? 6.59376   -13.06385 -30.67534 1.000 37.55984 ? 279 ARG B C   1 
ATOM   4463 O  O   . ARG B 1 279 ? 7.52168   -12.78360 -29.91507 1.000 35.24366 ? 279 ARG B O   1 
ATOM   4464 C  CB  . ARG B 1 279 ? 6.01778   -15.24095 -31.80388 1.000 43.33816 ? 279 ARG B CB  1 
ATOM   4465 C  CG  . ARG B 1 279 ? 5.92006   -15.97697 -33.12324 1.000 44.45670 ? 279 ARG B CG  1 
ATOM   4466 C  CD  . ARG B 1 279 ? 5.22251   -17.31778 -32.98891 1.000 49.62220 ? 279 ARG B CD  1 
ATOM   4467 N  NE  . ARG B 1 279 ? 6.12454   -18.35737 -32.50607 1.000 48.96295 ? 279 ARG B NE  1 
ATOM   4468 C  CZ  . ARG B 1 279 ? 5.93261   -19.65704 -32.69520 1.000 52.89141 ? 279 ARG B CZ  1 
ATOM   4469 N  NH1 . ARG B 1 279 ? 4.88036   -20.11113 -33.36085 1.000 52.29642 ? 279 ARG B NH1 1 
ATOM   4470 N  NH2 . ARG B 1 279 ? 6.82189   -20.52209 -32.21210 1.000 47.73215 ? 279 ARG B NH2 1 
ATOM   4471 N  N   . THR B 1 280 ? 5.35574   -12.61751 -30.49126 1.000 37.47892 ? 280 THR B N   1 
ATOM   4472 C  CA  . THR B 1 280 ? 4.97618   -11.86744 -29.30622 1.000 34.03340 ? 280 THR B CA  1 
ATOM   4473 C  C   . THR B 1 280 ? 3.86498   -12.59740 -28.56405 1.000 32.94415 ? 280 THR B C   1 
ATOM   4474 O  O   . THR B 1 280 ? 3.24394   -13.53534 -29.07397 1.000 31.60476 ? 280 THR B O   1 
ATOM   4475 C  CB  . THR B 1 280 ? 4.52340   -10.44274 -29.65136 1.000 31.41831 ? 280 THR B CB  1 
ATOM   4476 O  OG1 . THR B 1 280 ? 3.39866   -10.50148 -30.53207 1.000 32.97878 ? 280 THR B OG1 1 
ATOM   4477 C  CG2 . THR B 1 280 ? 5.65356   -9.65418  -30.29866 1.000 30.00540 ? 280 THR B CG2 1 
ATOM   4478 N  N   . ILE B 1 281 ? 3.63508   -12.14614 -27.33539 1.000 26.73815 ? 281 ILE B N   1 
ATOM   4479 C  CA  . ILE B 1 281 ? 2.58327   -12.65155 -26.46530 1.000 26.01041 ? 281 ILE B CA  1 
ATOM   4480 C  C   . ILE B 1 281 ? 1.89052   -11.44032 -25.85808 1.000 26.05713 ? 281 ILE B C   1 
ATOM   4481 O  O   . ILE B 1 281 ? 2.52312   -10.66781 -25.12791 1.000 26.48128 ? 281 ILE B O   1 
ATOM   4482 C  CB  . ILE B 1 281 ? 3.13795   -13.56990 -25.36239 1.000 25.53655 ? 281 ILE B CB  1 
ATOM   4483 C  CG1 . ILE B 1 281 ? 3.84764   -14.77887 -25.97200 1.000 26.90383 ? 281 ILE B CG1 1 
ATOM   4484 C  CG2 . ILE B 1 281 ? 2.02201   -14.01998 -24.42703 1.000 20.89216 ? 281 ILE B CG2 1 
ATOM   4485 C  CD1 . ILE B 1 281 ? 4.53568   -15.65543 -24.94706 1.000 30.00525 ? 281 ILE B CD1 1 
ATOM   4486 N  N   . LEU B 1 282 ? 0.60716   -11.25657 -26.17725 1.000 26.82286 ? 282 LEU B N   1 
ATOM   4487 C  CA  . LEU B 1 282 ? -0.15563  -10.10028 -25.69545 1.000 25.52167 ? 282 LEU B CA  1 
ATOM   4488 C  C   . LEU B 1 282 ? 0.55876   -8.78773  -26.00989 1.000 25.70795 ? 282 LEU B C   1 
ATOM   4489 O  O   . LEU B 1 282 ? 0.64623   -7.88576  -25.17453 1.000 27.53979 ? 282 LEU B O   1 
ATOM   4490 C  CB  . LEU B 1 282 ? -0.43690  -10.20851 -24.19430 1.000 24.30906 ? 282 LEU B CB  1 
ATOM   4491 C  CG  . LEU B 1 282 ? -1.50472  -11.23094 -23.80501 1.000 26.95059 ? 282 LEU B CG  1 
ATOM   4492 C  CD1 . LEU B 1 282 ? -1.64594  -11.31649 -22.29325 1.000 22.72574 ? 282 LEU B CD1 1 
ATOM   4493 C  CD2 . LEU B 1 282 ? -2.84297  -10.86979 -24.46358 1.000 25.31974 ? 282 LEU B CD2 1 
ATOM   4494 N  N   . GLY B 1 283 ? 1.09096   -8.68424  -27.22326 1.000 28.05089 ? 283 GLY B N   1 
ATOM   4495 C  CA  . GLY B 1 283 ? 1.76356   -7.46370  -27.62417 1.000 28.69642 ? 283 GLY B CA  1 
ATOM   4496 C  C   . GLY B 1 283 ? 3.09881   -7.19917  -26.95845 1.000 32.92784 ? 283 GLY B C   1 
ATOM   4497 O  O   . GLY B 1 283 ? 3.58473   -6.06738  -27.00416 1.000 35.20104 ? 283 GLY B O   1 
ATOM   4498 N  N   . SER B 1 284 ? 3.71370   -8.20500  -26.34316 1.000 29.23847 ? 284 SER B N   1 
ATOM   4499 C  CA  . SER B 1 284 ? 5.00927   -8.04735  -25.69743 1.000 29.89330 ? 284 SER B CA  1 
ATOM   4500 C  C   . SER B 1 284 ? 6.01609   -9.02194  -26.29258 1.000 28.72032 ? 284 SER B C   1 
ATOM   4501 O  O   . SER B 1 284 ? 5.67804   -10.16674 -26.61060 1.000 27.65463 ? 284 SER B O   1 
ATOM   4502 C  CB  . SER B 1 284 ? 4.91152   -8.27074  -24.18286 1.000 27.29043 ? 284 SER B CB  1 
ATOM   4503 O  OG  . SER B 1 284 ? 6.16079   -8.01807  -23.55568 1.000 27.58451 ? 284 SER B OG  1 
ATOM   4504 N  N   . ALA B 1 285 ? 7.25287   -8.55579  -26.44431 1.000 26.01565 ? 285 ALA B N   1 
ATOM   4505 C  CA  . ALA B 1 285 ? 8.37665   -9.41688  -26.77950 1.000 33.16749 ? 285 ALA B CA  1 
ATOM   4506 C  C   . ALA B 1 285 ? 9.12540   -9.91321  -25.54903 1.000 31.23087 ? 285 ALA B C   1 
ATOM   4507 O  O   . ALA B 1 285 ? 10.03588  -10.73750 -25.68870 1.000 31.61903 ? 285 ALA B O   1 
ATOM   4508 C  CB  . ALA B 1 285 ? 9.35683   -8.68633  -27.71095 1.000 30.60938 ? 285 ALA B CB  1 
ATOM   4509 N  N   . LEU B 1 286 ? 8.77476   -9.43378  -24.36015 1.000 30.76215 ? 286 LEU B N   1 
ATOM   4510 C  CA  . LEU B 1 286 ? 9.32670   -9.93341  -23.10957 1.000 28.88624 ? 286 LEU B CA  1 
ATOM   4511 C  C   . LEU B 1 286 ? 8.26599   -10.72232 -22.35615 1.000 27.63410 ? 286 LEU B C   1 
ATOM   4512 O  O   . LEU B 1 286 ? 7.06388   -10.55651 -22.57606 1.000 26.68569 ? 286 LEU B O   1 
ATOM   4513 C  CB  . LEU B 1 286 ? 9.83263   -8.78671  -22.22465 1.000 29.23894 ? 286 LEU B CB  1 
ATOM   4514 C  CG  . LEU B 1 286 ? 10.95569  -7.90526  -22.75971 1.000 34.65310 ? 286 LEU B CG  1 
ATOM   4515 C  CD1 . LEU B 1 286 ? 11.16531  -6.68246  -21.87223 1.000 29.89094 ? 286 LEU B CD1 1 
ATOM   4516 C  CD2 . LEU B 1 286 ? 12.24017  -8.71648  -22.88396 1.000 35.41985 ? 286 LEU B CD2 1 
ATOM   4517 N  N   . LEU B 1 287 ? 8.72344   -11.57850 -21.44784 1.000 25.70333 ? 287 LEU B N   1 
ATOM   4518 C  CA  . LEU B 1 287 ? 7.81748   -12.23540 -20.51438 1.000 27.21884 ? 287 LEU B CA  1 
ATOM   4519 C  C   . LEU B 1 287 ? 7.46146   -11.24920 -19.40706 1.000 24.49993 ? 287 LEU B C   1 
ATOM   4520 O  O   . LEU B 1 287 ? 8.33611   -10.81518 -18.65347 1.000 27.43721 ? 287 LEU B O   1 
ATOM   4521 C  CB  . LEU B 1 287 ? 8.46381   -13.50195 -19.95931 1.000 26.54395 ? 287 LEU B CB  1 
ATOM   4522 C  CG  . LEU B 1 287 ? 8.77096   -14.51236 -21.07352 1.000 27.11731 ? 287 LEU B CG  1 
ATOM   4523 C  CD1 . LEU B 1 287 ? 9.46216   -15.74988 -20.53236 1.000 29.71921 ? 287 LEU B CD1 1 
ATOM   4524 C  CD2 . LEU B 1 287 ? 7.50044   -14.89205 -21.79887 1.000 30.87427 ? 287 LEU B CD2 1 
ATOM   4525 N  N   . GLU B 1 288 ? 6.18595   -10.87653 -19.32982 1.000 24.55381 ? 288 GLU B N   1 
ATOM   4526 C  CA  A GLU B 1 288 ? 5.73770   -9.85534  -18.39005 0.500 24.97128 ? 288 GLU B CA  1 
ATOM   4527 C  CA  B GLU B 1 288 ? 5.73816   -9.85505  -18.39154 0.500 24.98649 ? 288 GLU B CA  1 
ATOM   4528 C  C   . GLU B 1 288 ? 5.49680   -10.47041 -17.01651 1.000 21.50395 ? 288 GLU B C   1 
ATOM   4529 O  O   . GLU B 1 288 ? 4.84542   -11.51331 -16.90258 1.000 19.72466 ? 288 GLU B O   1 
ATOM   4530 C  CB  A GLU B 1 288 ? 4.45828   -9.18726  -18.89959 0.500 24.39418 ? 288 GLU B CB  1 
ATOM   4531 C  CB  B GLU B 1 288 ? 4.46380   -9.18766  -18.91562 0.500 24.39242 ? 288 GLU B CB  1 
ATOM   4532 C  CG  A GLU B 1 288 ? 4.60031   -8.49136  -20.24540 0.500 26.99365 ? 288 GLU B CG  1 
ATOM   4533 C  CG  B GLU B 1 288 ? 3.89315   -8.11065  -18.01312 0.500 26.66201 ? 288 GLU B CG  1 
ATOM   4534 C  CD  A GLU B 1 288 ? 5.42004   -7.21195  -20.16560 0.500 31.82660 ? 288 GLU B CD  1 
ATOM   4535 C  CD  B GLU B 1 288 ? 4.79009   -6.89346  -17.90357 0.500 28.04543 ? 288 GLU B CD  1 
ATOM   4536 O  OE1 A GLU B 1 288 ? 5.32928   -6.50896  -19.13617 0.500 34.32009 ? 288 GLU B OE1 1 
ATOM   4537 O  OE1 B GLU B 1 288 ? 5.51331   -6.58515  -18.87649 0.500 34.39941 ? 288 GLU B OE1 1 
ATOM   4538 O  OE2 A GLU B 1 288 ? 6.15363   -6.90854  -21.12982 0.500 33.71701 ? 288 GLU B OE2 1 
ATOM   4539 O  OE2 B GLU B 1 288 ? 4.77384   -6.24626  -16.83632 0.500 33.71701 ? 288 GLU B OE2 1 
ATOM   4540 N  N   . ASP B 1 289 ? 6.01761   -9.81944  -15.96223 1.000 20.05716 ? 289 ASP B N   1 
ATOM   4541 C  CA  . ASP B 1 289 ? 5.86532   -10.34870 -14.60625 1.000 20.98600 ? 289 ASP B CA  1 
ATOM   4542 C  C   . ASP B 1 289 ? 5.23272   -9.36378  -13.61890 1.000 22.48329 ? 289 ASP B C   1 
ATOM   4543 O  O   . ASP B 1 289 ? 5.36768   -9.54505  -12.40373 1.000 22.76125 ? 289 ASP B O   1 
ATOM   4544 C  CB  . ASP B 1 289 ? 7.21011   -10.86027 -14.07162 1.000 20.83389 ? 289 ASP B CB  1 
ATOM   4545 C  CG  . ASP B 1 289 ? 8.14868   -9.75036  -13.60611 1.000 25.73184 ? 289 ASP B CG  1 
ATOM   4546 O  OD1 . ASP B 1 289 ? 7.94540   -8.57089  -13.94729 1.000 24.22248 ? 289 ASP B OD1 1 
ATOM   4547 O  OD2 . ASP B 1 289 ? 9.12912   -10.08128 -12.90319 1.000 24.49218 ? 289 ASP B OD2 1 
ATOM   4548 N  N   . GLU B 1 290 ? 4.51118   -8.34257  -14.08330 1.000 22.54083 ? 290 GLU B N   1 
ATOM   4549 C  CA  . GLU B 1 290 ? 3.86795   -7.42550  -13.14492 1.000 23.51481 ? 290 GLU B CA  1 
ATOM   4550 C  C   . GLU B 1 290 ? 2.34203   -7.58458  -13.12307 1.000 21.05455 ? 290 GLU B C   1 
ATOM   4551 O  O   . GLU B 1 290 ? 1.61829   -6.63365  -12.82566 1.000 20.45738 ? 290 GLU B O   1 
ATOM   4552 C  CB  . GLU B 1 290 ? 4.30051   -5.97942  -13.42372 1.000 21.58315 ? 290 GLU B CB  1 
ATOM   4553 C  CG  . GLU B 1 290 ? 5.84151   -5.83623  -13.39338 1.000 25.16013 ? 290 GLU B CG  1 
ATOM   4554 C  CD  . GLU B 1 290 ? 6.38797   -4.55408  -12.74182 1.000 30.24661 ? 290 GLU B CD  1 
ATOM   4555 O  OE1 . GLU B 1 290 ? 5.74534   -3.49262  -12.81980 1.000 24.52770 ? 290 GLU B OE1 1 
ATOM   4556 O  OE2 . GLU B 1 290 ? 7.51029   -4.60724  -12.17251 1.000 34.13903 ? 290 GLU B OE2 1 
ATOM   4557 N  N   . PHE B 1 291 ? 1.84184   -8.79505  -13.40011 1.000 18.91177 ? 291 PHE B N   1 
ATOM   4558 C  CA  . PHE B 1 291 ? 0.44088   -9.15846  -13.17718 1.000 20.69569 ? 291 PHE B CA  1 
ATOM   4559 C  C   . PHE B 1 291 ? 0.39541   -10.36793 -12.25139 1.000 19.64051 ? 291 PHE B C   1 
ATOM   4560 O  O   . PHE B 1 291 ? 0.97583   -11.40928 -12.56707 1.000 18.75293 ? 291 PHE B O   1 
ATOM   4561 C  CB  . PHE B 1 291 ? -0.28583  -9.51533  -14.47871 1.000 20.11272 ? 291 PHE B CB  1 
ATOM   4562 C  CG  . PHE B 1 291 ? -0.35407  -8.40368  -15.49040 1.000 24.96476 ? 291 PHE B CG  1 
ATOM   4563 C  CD1 . PHE B 1 291 ? -1.40240  -7.49448  -15.47051 1.000 22.26918 ? 291 PHE B CD1 1 
ATOM   4564 C  CD2 . PHE B 1 291 ? 0.60358   -8.29648  -16.48742 1.000 23.45939 ? 291 PHE B CD2 1 
ATOM   4565 C  CE1 . PHE B 1 291 ? -1.48172  -6.48142  -16.41963 1.000 23.77640 ? 291 PHE B CE1 1 
ATOM   4566 C  CE2 . PHE B 1 291 ? 0.52689   -7.28663  -17.45251 1.000 28.46660 ? 291 PHE B CE2 1 
ATOM   4567 C  CZ  . PHE B 1 291 ? -0.51415  -6.37597  -17.41054 1.000 24.63722 ? 291 PHE B CZ  1 
ATOM   4568 N  N   . THR B 1 292 ? -0.30720  -10.25086 -11.13355 1.000 17.53012 ? 292 THR B N   1 
ATOM   4569 C  CA  . THR B 1 292 ? -0.49472  -11.39853 -10.25182 1.000 20.25631 ? 292 THR B CA  1 
ATOM   4570 C  C   . THR B 1 292 ? -1.62300  -12.27976 -10.77841 1.000 21.05934 ? 292 THR B C   1 
ATOM   4571 O  O   . THR B 1 292 ? -2.38309  -11.87349 -11.66227 1.000 19.01806 ? 292 THR B O   1 
ATOM   4572 C  CB  . THR B 1 292 ? -0.80977  -10.93347 -8.83120  1.000 20.26531 ? 292 THR B CB  1 
ATOM   4573 O  OG1 . THR B 1 292 ? -2.13716  -10.38978 -8.79371  1.000 19.80719 ? 292 THR B OG1 1 
ATOM   4574 C  CG2 . THR B 1 292 ? 0.21117   -9.88476  -8.35511  1.000 16.75229 ? 292 THR B CG2 1 
ATOM   4575 N  N   . PRO B 1 293 ? -1.74998  -13.51313 -10.26337 1.000 21.45922 ? 293 PRO B N   1 
ATOM   4576 C  CA  . PRO B 1 293 ? -2.94376  -14.31129 -10.59010 1.000 23.43456 ? 293 PRO B CA  1 
ATOM   4577 C  C   . PRO B 1 293 ? -4.24663  -13.58582 -10.30329 1.000 24.80347 ? 293 PRO B C   1 
ATOM   4578 O  O   . PRO B 1 293 ? -5.18341  -13.64453 -11.11422 1.000 22.11019 ? 293 PRO B O   1 
ATOM   4579 C  CB  . PRO B 1 293 ? -2.76660  -15.55634 -9.71392  1.000 18.11496 ? 293 PRO B CB  1 
ATOM   4580 C  CG  . PRO B 1 293 ? -1.29224  -15.72885 -9.64625  1.000 21.88149 ? 293 PRO B CG  1 
ATOM   4581 C  CD  . PRO B 1 293 ? -0.72126  -14.33080 -9.58970  1.000 21.82269 ? 293 PRO B CD  1 
ATOM   4582 N  N   . PHE B 1 294 ? -4.31149  -12.86993 -9.17777  1.000 25.10188 ? 294 PHE B N   1 
ATOM   4583 C  CA  A PHE B 1 294 ? -5.53316  -12.15227 -8.83473  0.500 27.32180 ? 294 PHE B CA  1 
ATOM   4584 C  CA  B PHE B 1 294 ? -5.52444  -12.13800 -8.82433  0.500 27.45864 ? 294 PHE B CA  1 
ATOM   4585 C  C   . PHE B 1 294 ? -5.79708  -11.01143 -9.81412  1.000 25.50221 ? 294 PHE B C   1 
ATOM   4586 O  O   . PHE B 1 294 ? -6.94833  -10.78161 -10.20224 1.000 26.27999 ? 294 PHE B O   1 
ATOM   4587 C  CB  A PHE B 1 294 ? -5.44980  -11.65014 -7.39039  0.500 28.75547 ? 294 PHE B CB  1 
ATOM   4588 C  CB  B PHE B 1 294 ? -5.40533  -11.59266 -7.39894  0.500 29.09707 ? 294 PHE B CB  1 
ATOM   4589 C  CG  A PHE B 1 294 ? -4.99781  -12.70454 -6.41296  0.500 30.08670 ? 294 PHE B CG  1 
ATOM   4590 C  CG  B PHE B 1 294 ? -6.66353  -10.95557 -6.88059  0.500 31.30559 ? 294 PHE B CG  1 
ATOM   4591 C  CD1 A PHE B 1 294 ? -5.89256  -13.63640 -5.91142  0.500 32.78852 ? 294 PHE B CD1 1 
ATOM   4592 C  CD1 B PHE B 1 294 ? -7.68969  -11.72767 -6.37127  0.500 37.79305 ? 294 PHE B CD1 1 
ATOM   4593 C  CD2 A PHE B 1 294 ? -3.66986  -12.77419 -6.00986  0.500 33.51263 ? 294 PHE B CD2 1 
ATOM   4594 C  CD2 B PHE B 1 294 ? -6.81655  -9.58329  -6.88151  0.500 36.59890 ? 294 PHE B CD2 1 
ATOM   4595 C  CE1 A PHE B 1 294 ? -5.47695  -14.61194 -5.02243  0.500 32.87572 ? 294 PHE B CE1 1 
ATOM   4596 C  CE1 B PHE B 1 294 ? -8.84807  -11.13673 -5.88618  0.500 38.77863 ? 294 PHE B CE1 1 
ATOM   4597 C  CE2 A PHE B 1 294 ? -3.25095  -13.74702 -5.11785  0.500 36.92701 ? 294 PHE B CE2 1 
ATOM   4598 C  CE2 B PHE B 1 294 ? -7.97452  -9.00389  -6.39433  0.500 38.29161 ? 294 PHE B CE2 1 
ATOM   4599 C  CZ  A PHE B 1 294 ? -4.15836  -14.66698 -4.62343  0.500 33.92286 ? 294 PHE B CZ  1 
ATOM   4600 C  CZ  B PHE B 1 294 ? -8.98696  -9.77698  -5.90099  0.500 37.93733 ? 294 PHE B CZ  1 
ATOM   4601 N  N   . ASP B 1 295 ? -4.74516  -10.29116 -10.23080 1.000 24.81709 ? 295 ASP B N   1 
ATOM   4602 C  CA  . ASP B 1 295 ? -4.89493  -9.26617  -11.26579 1.000 25.92541 ? 295 ASP B CA  1 
ATOM   4603 C  C   . ASP B 1 295 ? -5.54463  -9.84752  -12.51414 1.000 24.09079 ? 295 ASP B C   1 
ATOM   4604 O  O   . ASP B 1 295 ? -6.48978  -9.27353  -13.06783 1.000 24.01898 ? 295 ASP B O   1 
ATOM   4605 C  CB  . ASP B 1 295 ? -3.53394  -8.65944  -11.65076 1.000 21.32634 ? 295 ASP B CB  1 
ATOM   4606 C  CG  . ASP B 1 295 ? -2.88949  -7.85345  -10.52619 1.000 23.23638 ? 295 ASP B CG  1 
ATOM   4607 O  OD1 . ASP B 1 295 ? -3.60181  -7.44097  -9.59119  1.000 27.95823 ? 295 ASP B OD1 1 
ATOM   4608 O  OD2 . ASP B 1 295 ? -1.66018  -7.62022  -10.59004 1.000 19.75337 ? 295 ASP B OD2 1 
ATOM   4609 N  N   . VAL B 1 296 ? -5.02427  -10.98491 -12.98161 1.000 19.79707 ? 296 VAL B N   1 
ATOM   4610 C  CA  . VAL B 1 296 ? -5.51507  -11.58876 -14.21341 1.000 23.44892 ? 296 VAL B CA  1 
ATOM   4611 C  C   . VAL B 1 296 ? -6.98911  -11.94790 -14.07086 1.000 27.06805 ? 296 VAL B C   1 
ATOM   4612 O  O   . VAL B 1 296 ? -7.80529  -11.66495 -14.95826 1.000 27.66201 ? 296 VAL B O   1 
ATOM   4613 C  CB  . VAL B 1 296 ? -4.66441  -12.81930 -14.58646 1.000 20.83689 ? 296 VAL B CB  1 
ATOM   4614 C  CG1 . VAL B 1 296 ? -5.26700  -13.52762 -15.79279 1.000 22.05987 ? 296 VAL B CG1 1 
ATOM   4615 C  CG2 . VAL B 1 296 ? -3.23377  -12.40942 -14.87983 1.000 22.45311 ? 296 VAL B CG2 1 
ATOM   4616 N  N   . VAL B 1 297 ? -7.35003  -12.56554 -12.94175 1.000 26.65967 ? 297 VAL B N   1 
ATOM   4617 C  CA  . VAL B 1 297 ? -8.73878  -12.96080 -12.71233 1.000 26.73722 ? 297 VAL B CA  1 
ATOM   4618 C  C   . VAL B 1 297 ? -9.64114  -11.73607 -12.69088 1.000 29.70825 ? 297 VAL B C   1 
ATOM   4619 O  O   . VAL B 1 297 ? -10.70866 -11.71362 -13.31346 1.000 28.73190 ? 297 VAL B O   1 
ATOM   4620 C  CB  . VAL B 1 297 ? -8.86445  -13.76847 -11.40805 1.000 27.02884 ? 297 VAL B CB  1 
ATOM   4621 C  CG1 . VAL B 1 297 ? -10.33661 -14.03555 -11.09320 1.000 31.35951 ? 297 VAL B CG1 1 
ATOM   4622 C  CG2 . VAL B 1 297 ? -8.09413  -15.07108 -11.51798 1.000 26.89734 ? 297 VAL B CG2 1 
ATOM   4623 N  N   . ARG B 1 298 ? -9.22928  -10.70253 -11.96241 1.000 28.81985 ? 298 ARG B N   1 
ATOM   4624 C  CA  . ARG B 1 298 ? -10.04103 -9.49534  -11.85714 1.000 29.56084 ? 298 ARG B CA  1 
ATOM   4625 C  C   . ARG B 1 298 ? -10.22820 -8.82994  -13.21963 1.000 32.25481 ? 298 ARG B C   1 
ATOM   4626 O  O   . ARG B 1 298 ? -11.35626 -8.51823  -13.62057 1.000 30.23138 ? 298 ARG B O   1 
ATOM   4627 C  CB  . ARG B 1 298 ? -9.39748  -8.53606  -10.85984 1.000 34.15398 ? 298 ARG B CB  1 
ATOM   4628 C  CG  . ARG B 1 298 ? -10.02518 -7.17168  -10.78587 1.000 39.24403 ? 298 ARG B CG  1 
ATOM   4629 C  CD  . ARG B 1 298 ? -8.98183  -6.16939  -10.32247 1.000 48.85240 ? 298 ARG B CD  1 
ATOM   4630 N  NE  . ARG B 1 298 ? -8.53517  -6.42338  -8.95775  1.000 52.07515 ? 298 ARG B NE  1 
ATOM   4631 C  CZ  . ARG B 1 298 ? -7.29243  -6.23098  -8.53333  1.000 54.20508 ? 298 ARG B CZ  1 
ATOM   4632 N  NH1 . ARG B 1 298 ? -6.32154  -5.88663  -9.36473  1.000 44.66529 ? 298 ARG B NH1 1 
ATOM   4633 N  NH2 . ARG B 1 298 ? -7.01535  -6.38588  -7.24296  1.000 49.74233 ? 298 ARG B NH2 1 
ATOM   4634 N  N   . GLN B 1 299 ? -9.13588  -8.62559  -13.96101 1.000 27.12112 ? 299 GLN B N   1 
ATOM   4635 C  CA  . GLN B 1 299 ? -9.25302  -7.91289  -15.22941 1.000 29.44904 ? 299 GLN B CA  1 
ATOM   4636 C  C   . GLN B 1 299 ? -10.05091 -8.71517  -16.25017 1.000 32.91101 ? 299 GLN B C   1 
ATOM   4637 O  O   . GLN B 1 299 ? -10.82287 -8.14235  -17.02750 1.000 31.92571 ? 299 GLN B O   1 
ATOM   4638 C  CB  . GLN B 1 299 ? -7.87528  -7.56229  -15.79748 1.000 24.10577 ? 299 GLN B CB  1 
ATOM   4639 C  CG  . GLN B 1 299 ? -7.97689  -6.82064  -17.13706 1.000 21.34398 ? 299 GLN B CG  1 
ATOM   4640 C  CD  . GLN B 1 299 ? -6.65578  -6.25487  -17.62866 1.000 24.59507 ? 299 GLN B CD  1 
ATOM   4641 O  OE1 . GLN B 1 299 ? -6.54401  -5.84541  -18.78368 1.000 25.15178 ? 299 GLN B OE1 1 
ATOM   4642 N  NE2 . GLN B 1 299 ? -5.65104  -6.23178  -16.75912 1.000 18.09014 ? 299 GLN B NE2 1 
ATOM   4643 N  N   . CYS B 1 300 ? -9.87896  -10.03744 -16.26824 1.000 31.78272 ? 300 CYS B N   1 
ATOM   4644 C  CA  . CYS B 1 300 ? -10.58670 -10.86975 -17.23129 1.000 26.93027 ? 300 CYS B CA  1 
ATOM   4645 C  C   . CYS B 1 300 ? -12.00822 -11.21126 -16.79106 1.000 31.87972 ? 300 CYS B C   1 
ATOM   4646 O  O   . CYS B 1 300 ? -12.75322 -11.79581 -17.58106 1.000 37.26148 ? 300 CYS B O   1 
ATOM   4647 C  CB  . CYS B 1 300 ? -9.79698  -12.15729 -17.49856 1.000 33.40760 ? 300 CYS B CB  1 
ATOM   4648 S  SG  . CYS B 1 300 ? -8.17239  -11.90621 -18.27448 1.000 34.99722 ? 300 CYS B SG  1 
ATOM   4649 N  N   . SER B 1 301 ? -12.40590 -10.85237 -15.56647 1.000 35.34218 ? 301 SER B N   1 
ATOM   4650 C  CA  . SER B 1 301 ? -13.77188 -11.04541 -15.09451 1.000 32.84740 ? 301 SER B CA  1 
ATOM   4651 C  C   . SER B 1 301 ? -14.51021 -9.74369  -14.80374 1.000 37.40089 ? 301 SER B C   1 
ATOM   4652 O  O   . SER B 1 301 ? -15.72235 -9.78568  -14.55977 1.000 40.05941 ? 301 SER B O   1 
ATOM   4653 C  CB  . SER B 1 301 ? -13.79035 -11.92211 -13.83193 1.000 35.82165 ? 301 SER B CB  1 
ATOM   4654 O  OG  . SER B 1 301 ? -13.46090 -11.17210 -12.67208 1.000 34.83431 ? 301 SER B OG  1 
ATOM   4655 N  N   . GLY B 1 302 ? -13.82751 -8.60137  -14.81153 1.000 34.79069 ? 302 GLY B N   1 
ATOM   4656 C  CA  . GLY B 1 302 ? -14.49513 -7.31205  -14.71417 1.000 35.43028 ? 302 GLY B CA  1 
ATOM   4657 C  C   . GLY B 1 302 ? -14.92294 -6.87820  -13.32702 1.000 36.11894 ? 302 GLY B C   1 
ATOM   4658 O  O   . GLY B 1 302 ? -16.00880 -6.30106  -13.17154 1.000 32.55754 ? 302 GLY B O   1 
ATOM   4659 N  N   . VAL B 1 303 ? -14.08765 -7.11702  -12.31221 1.000 36.74545 ? 303 VAL B N   1 
ATOM   4660 C  CA  . VAL B 1 303 ? -14.42218 -6.73051  -10.94514 1.000 35.27310 ? 303 VAL B CA  1 
ATOM   4661 C  C   . VAL B 1 303 ? -14.36795 -5.21279  -10.80363 1.000 36.92020 ? 303 VAL B C   1 
ATOM   4662 O  O   . VAL B 1 303 ? -13.47889 -4.54959  -11.35253 1.000 33.26851 ? 303 VAL B O   1 
ATOM   4663 C  CB  . VAL B 1 303 ? -13.47102 -7.42316  -9.95202  1.000 39.51432 ? 303 VAL B CB  1 
ATOM   4664 C  CG1 . VAL B 1 303 ? -13.65975 -6.88421  -8.53410  1.000 36.40889 ? 303 VAL B CG1 1 
ATOM   4665 C  CG2 . VAL B 1 303 ? -13.66680 -8.93717  -9.99016  1.000 37.79237 ? 303 VAL B CG2 1 
ATOM   4666 N  N   . THR B 1 304 ? -15.31954 -4.65622  -10.05419 1.000 32.79649 ? 304 THR B N   1 
ATOM   4667 C  CA  . THR B 1 304 ? -15.44376 -3.22152  -9.82890  1.000 36.66944 ? 304 THR B CA  1 
ATOM   4668 C  C   . THR B 1 304 ? -15.26297 -2.88039  -8.35038  1.000 37.92545 ? 304 THR B C   1 
ATOM   4669 O  O   . THR B 1 304 ? -15.22384 -3.75539  -7.47785  1.000 39.99148 ? 304 THR B O   1 
ATOM   4670 C  CB  . THR B 1 304 ? -16.80499 -2.71365  -10.31386 1.000 32.08938 ? 304 THR B CB  1 
ATOM   4671 O  OG1 . THR B 1 304 ? -17.83479 -3.54743  -9.76866  1.000 36.29310 ? 304 THR B OG1 1 
ATOM   4672 C  CG2 . THR B 1 304 ? -16.86906 -2.74785  -11.82552 1.000 24.84457 ? 304 THR B CG2 1 
ATOM   4673 N  N   . PHE B 1 305 ? -15.16634 -1.58039  -8.07737  1.000 37.00862 ? 305 PHE B N   1 
ATOM   4674 C  CA  . PHE B 1 305 ? -14.89906 -1.08538  -6.72904  1.000 36.12036 ? 305 PHE B CA  1 
ATOM   4675 C  C   . PHE B 1 305 ? -15.86191 0.04291   -6.34142  1.000 47.74403 ? 305 PHE B C   1 
ATOM   4676 O  O   . PHE B 1 305 ? -16.49469 0.00280   -5.27511  1.000 46.78928 ? 305 PHE B O   1 
ATOM   4677 C  CB  . PHE B 1 305 ? -13.44719 -0.61114  -6.62706  1.000 37.81504 ? 305 PHE B CB  1 
ATOM   4678 C  CG  . PHE B 1 305 ? -12.45306 -1.62881  -7.11126  1.000 36.81102 ? 305 PHE B CG  1 
ATOM   4679 C  CD1 . PHE B 1 305 ? -12.13175 -2.72248  -6.32607  1.000 35.93360 ? 305 PHE B CD1 1 
ATOM   4680 C  CD2 . PHE B 1 305 ? -11.86351 -1.50929  -8.36854  1.000 36.48763 ? 305 PHE B CD2 1 
ATOM   4681 C  CE1 . PHE B 1 305 ? -11.23295 -3.67806  -6.77214  1.000 36.72944 ? 305 PHE B CE1 1 
ATOM   4682 C  CE2 . PHE B 1 305 ? -10.96007 -2.46081  -8.82735  1.000 33.47779 ? 305 PHE B CE2 1 
ATOM   4683 C  CZ  . PHE B 1 305 ? -10.64687 -3.54870  -8.02940  1.000 39.98325 ? 305 PHE B CZ  1 
HETATM 4684 C  C1  . XEK C 2 .   ? -20.37608 -4.85920  -27.70414 1.000 28.92823 ? 401 XEK A C1  1 
HETATM 4685 C  C2  . XEK C 2 .   ? -21.69149 -4.64334  -28.11384 1.000 28.81154 ? 401 XEK A C2  1 
HETATM 4686 C  C3  . XEK C 2 .   ? -22.01204 -4.34352  -29.58057 1.000 31.20835 ? 401 XEK A C3  1 
HETATM 4687 C  C4  . XEK C 2 .   ? -22.87289 -3.28101  -29.83811 1.000 28.18465 ? 401 XEK A C4  1 
HETATM 4688 C  C5  . XEK C 2 .   ? -23.18090 -2.96144  -31.14783 1.000 35.97411 ? 401 XEK A C5  1 
HETATM 4689 C  C6  . XEK C 2 .   ? -22.64583 -3.69773  -32.19028 1.000 31.09728 ? 401 XEK A C6  1 
HETATM 4690 C  C7  . XEK C 2 .   ? -21.78675 -4.76511  -31.95265 1.000 36.24445 ? 401 XEK A C7  1 
HETATM 4691 C  C8  . XEK C 2 .   ? -20.19556 -6.36684  -32.84912 1.000 41.50591 ? 401 XEK A C8  1 
HETATM 4692 C  C9  . XEK C 2 .   ? -19.89974 -7.04452  -34.19911 1.000 44.57450 ? 401 XEK A C9  1 
HETATM 4693 C  C10 . XEK C 2 .   ? -20.24745 -8.37423  -34.41793 1.000 45.33418 ? 401 XEK A C10 1 
HETATM 4694 C  C11 . XEK C 2 .   ? -19.97515 -8.97110  -35.64874 1.000 42.56980 ? 401 XEK A C11 1 
HETATM 4695 C  C12 . XEK C 2 .   ? -19.35638 -8.24551  -36.66375 1.000 41.81069 ? 401 XEK A C12 1 
HETATM 4696 C  C13 . XEK C 2 .   ? -19.00971 -6.91756  -36.44792 1.000 41.46852 ? 401 XEK A C13 1 
HETATM 4697 C  C14 . XEK C 2 .   ? -19.28799 -6.32185  -35.22047 1.000 41.48765 ? 401 XEK A C14 1 
HETATM 4698 C  C15 . XEK C 2 .   ? -21.47353 -5.09410  -30.63451 1.000 34.83881 ? 401 XEK A C15 1 
HETATM 4699 C  C17 . XEK C 2 .   ? -22.44625 -4.91229  -25.84708 1.000 33.43509 ? 401 XEK A C17 1 
HETATM 4700 C  C21 . XEK C 2 .   ? -27.08835 -6.17246  -24.80665 1.000 40.21740 ? 401 XEK A C21 1 
HETATM 4701 C  C22 . XEK C 2 .   ? -25.66916 -5.25226  -23.06613 1.000 41.35997 ? 401 XEK A C22 1 
HETATM 4702 C  C24 . XEK C 2 .   ? -18.77679 -5.34836  -25.94396 1.000 27.37599 ? 401 XEK A C24 1 
HETATM 4703 C  C25 . XEK C 2 .   ? -18.38719 -6.62442  -25.55630 1.000 24.53202 ? 401 XEK A C25 1 
HETATM 4704 C  C27 . XEK C 2 .   ? -16.21737 -5.70973  -25.07978 1.000 25.98760 ? 401 XEK A C27 1 
HETATM 4705 C  C16 . XEK C 2 .   ? -22.73050 -4.66712  -27.18661 1.000 32.11918 ? 401 XEK A C16 1 
HETATM 4706 C  C18 . XEK C 2 .   ? -23.57484 -4.99049  -24.80818 1.000 35.39577 ? 401 XEK A C18 1 
HETATM 4707 C  C19 . XEK C 2 .   ? -23.45151 -4.61922  -23.46084 1.000 38.36931 ? 401 XEK A C19 1 
HETATM 4708 C  C20 . XEK C 2 .   ? -24.79992 -5.51833  -25.21431 1.000 37.65741 ? 401 XEK A C20 1 
HETATM 4709 C  C23 . XEK C 2 .   ? -21.11735 -5.14657  -25.50071 1.000 31.13626 ? 401 XEK A C23 1 
HETATM 4710 C  C26 . XEK C 2 .   ? -17.07441 -6.80471  -25.11753 1.000 27.22514 ? 401 XEK A C26 1 
HETATM 4711 C  C28 . XEK C 2 .   ? -17.87392 -4.28904  -25.88398 1.000 26.27479 ? 401 XEK A C28 1 
HETATM 4712 F  F1  . XEK C 2 .   ? -22.99856 -3.33991  -33.45166 1.000 36.15727 ? 401 XEK A F1  1 
HETATM 4713 N  N1  . XEK C 2 .   ? -24.50071 -4.75403  -22.63641 1.000 36.95858 ? 401 XEK A N1  1 
HETATM 4714 N  N2  . XEK C 2 .   ? -25.81617 -5.63157  -24.34785 1.000 43.34419 ? 401 XEK A N2  1 
HETATM 4715 N  N3  . XEK C 2 .   ? -20.13323 -5.10895  -26.40754 1.000 28.62770 ? 401 XEK A N3  1 
HETATM 4716 N  N4  . XEK C 2 .   ? -16.62155 -4.48853  -25.45695 1.000 25.43684 ? 401 XEK A N4  1 
HETATM 4717 O  O1  . XEK C 2 .   ? -19.33515 -4.84150  -28.64667 1.000 27.17355 ? 401 XEK A O1  1 
HETATM 4718 O  O2  . XEK C 2 .   ? -21.27091 -5.47842  -33.05830 1.000 41.62560 ? 401 XEK A O2  1 
HETATM 4719 O  O3  . XEK C 2 .   ? -22.26713 -4.08169  -22.94126 1.000 32.29391 ? 401 XEK A O3  1 
HETATM 4720 O  O4  . XEK C 2 .   ? -26.57605 -5.35569  -22.30094 1.000 40.95682 ? 401 XEK A O4  1 
HETATM 4721 CL CL1 . XEK C 2 .   ? -24.28084 -1.61020  -31.54116 1.000 43.99824 ? 401 XEK A CL1 1 
HETATM 4722 CL CL2 . XEK C 2 .   ? -18.84551 -4.61451  -34.94211 1.000 55.59725 ? 401 XEK A CL2 1 
HETATM 4723 O  O   . HOH D 3 .   ? 22.20365  15.01184  -35.01434 1.000 31.87762 ? 501 HOH A O   1 
HETATM 4724 O  O   . HOH D 3 .   ? -29.68855 7.82663   -37.21956 1.000 38.50862 ? 502 HOH A O   1 
HETATM 4725 O  O   . HOH D 3 .   ? -38.04140 -0.26394  -35.02875 1.000 35.13390 ? 503 HOH A O   1 
HETATM 4726 O  O   . HOH D 3 .   ? 13.70936  9.74507   -51.87465 1.000 35.17285 ? 504 HOH A O   1 
HETATM 4727 O  O   . HOH D 3 .   ? -21.97052 12.86192  -8.25989  1.000 35.44762 ? 505 HOH A O   1 
HETATM 4728 O  O   . HOH D 3 .   ? -41.23802 4.11057   -38.12929 1.000 31.00302 ? 506 HOH A O   1 
HETATM 4729 O  O   . HOH D 3 .   ? 8.42131   -1.74707  -35.09880 1.000 26.28927 ? 507 HOH A O   1 
HETATM 4730 O  O   . HOH D 3 .   ? -0.47518  8.97288   -39.70872 1.000 34.37393 ? 508 HOH A O   1 
HETATM 4731 O  O   . HOH D 3 .   ? -28.88807 0.78344   -38.23027 1.000 29.98736 ? 509 HOH A O   1 
HETATM 4732 O  O   . HOH D 3 .   ? -20.42830 -5.18309  -12.13882 1.000 38.29711 ? 510 HOH A O   1 
HETATM 4733 O  O   . HOH D 3 .   ? -17.50500 15.43528  -33.76721 1.000 31.80571 ? 511 HOH A O   1 
HETATM 4734 O  O   . HOH D 3 .   ? -34.06540 6.52674   -13.73260 1.000 34.19040 ? 512 HOH A O   1 
HETATM 4735 O  O   . HOH D 3 .   ? -32.69047 18.94369  -15.59256 1.000 40.51163 ? 513 HOH A O   1 
HETATM 4736 O  O   . HOH D 3 .   ? 15.89466  -1.06828  -21.16353 1.000 36.83354 ? 514 HOH A O   1 
HETATM 4737 O  O   . HOH D 3 .   ? -22.49348 -2.21346  -17.51230 1.000 20.82147 ? 515 HOH A O   1 
HETATM 4738 O  O   . HOH D 3 .   ? 19.06070  -0.52090  -22.57726 1.000 38.23525 ? 516 HOH A O   1 
HETATM 4739 O  O   . HOH D 3 .   ? 7.46026   23.83036  -41.13873 1.000 38.24155 ? 517 HOH A O   1 
HETATM 4740 O  O   . HOH D 3 .   ? -8.50210  -5.49207  -36.16831 1.000 39.26505 ? 518 HOH A O   1 
HETATM 4741 O  O   . HOH D 3 .   ? 1.29515   10.19831  -41.22633 1.000 31.84918 ? 519 HOH A O   1 
HETATM 4742 O  O   . HOH D 3 .   ? 23.06959  11.97633  -25.12778 1.000 33.61387 ? 520 HOH A O   1 
HETATM 4743 O  O   . HOH D 3 .   ? -18.79736 2.13290   -7.37353  1.000 40.59709 ? 521 HOH A O   1 
HETATM 4744 O  O   . HOH D 3 .   ? 15.54968  -7.95907  -26.85346 1.000 36.60733 ? 522 HOH A O   1 
HETATM 4745 O  O   . HOH D 3 .   ? -12.17466 -3.78706  -18.44319 1.000 24.31142 ? 523 HOH A O   1 
HETATM 4746 O  O   . HOH D 3 .   ? 25.61340  1.71548   -38.76192 1.000 30.33228 ? 524 HOH A O   1 
HETATM 4747 O  O   . HOH D 3 .   ? -23.69620 18.05039  -20.32028 1.000 31.67099 ? 525 HOH A O   1 
HETATM 4748 O  O   . HOH D 3 .   ? -24.24256 -5.14217  -19.60477 1.000 38.19384 ? 526 HOH A O   1 
HETATM 4749 O  O   . HOH D 3 .   ? 6.29634   18.85361  -16.85429 1.000 48.66253 ? 527 HOH A O   1 
HETATM 4750 O  O   . HOH D 3 .   ? 12.58508  -8.05357  -29.56117 1.000 42.29005 ? 528 HOH A O   1 
HETATM 4751 O  O   . HOH D 3 .   ? -10.92079 -6.45585  -19.45339 1.000 26.37464 ? 529 HOH A O   1 
HETATM 4752 O  O   . HOH D 3 .   ? 18.87327  9.34675   -47.53628 1.000 21.31712 ? 530 HOH A O   1 
HETATM 4753 O  O   . HOH D 3 .   ? 4.62295   -1.95621  -37.86301 1.000 30.32854 ? 531 HOH A O   1 
HETATM 4754 O  O   . HOH D 3 .   ? 23.60143  10.46383  -36.96480 1.000 32.50264 ? 532 HOH A O   1 
HETATM 4755 O  O   . HOH D 3 .   ? -2.57623  11.22763  -22.87141 1.000 25.56182 ? 533 HOH A O   1 
HETATM 4756 O  O   . HOH D 3 .   ? 1.04118   15.28392  -40.21610 1.000 31.36019 ? 534 HOH A O   1 
HETATM 4757 O  O   . HOH D 3 .   ? -18.15161 6.10433   -39.23396 1.000 29.43813 ? 535 HOH A O   1 
HETATM 4758 O  O   . HOH D 3 .   ? 21.66121  8.03296   -35.74661 1.000 31.25561 ? 536 HOH A O   1 
HETATM 4759 O  O   . HOH D 3 .   ? 19.085    6.419     -49.073   1.000 24.24556 ? 537 HOH A O   1 
HETATM 4760 O  O   . HOH D 3 .   ? -36.74975 9.42076   -32.74279 1.000 27.44888 ? 538 HOH A O   1 
HETATM 4761 O  O   . HOH D 3 .   ? 1.23110   11.60364  -32.09318 1.000 25.20086 ? 539 HOH A O   1 
HETATM 4762 O  O   . HOH D 3 .   ? -30.27773 -7.03225  -23.19799 1.000 40.32118 ? 540 HOH A O   1 
HETATM 4763 O  O   . HOH D 3 .   ? -15.56609 14.12382  -27.74414 1.000 25.81757 ? 541 HOH A O   1 
HETATM 4764 O  O   . HOH D 3 .   ? -34.92090 -2.60077  -39.13355 1.000 35.64411 ? 542 HOH A O   1 
HETATM 4765 O  O   . HOH D 3 .   ? 2.60545   2.81296   -44.22809 1.000 34.66504 ? 543 HOH A O   1 
HETATM 4766 O  O   . HOH D 3 .   ? 11.83971  -4.85879  -38.02027 1.000 25.95089 ? 544 HOH A O   1 
HETATM 4767 O  O   . HOH D 3 .   ? -14.18015 -10.33223 -30.12111 1.000 35.74754 ? 545 HOH A O   1 
HETATM 4768 O  O   . HOH D 3 .   ? -1.79191  20.26921  -19.48176 1.000 51.25011 ? 546 HOH A O   1 
HETATM 4769 O  O   . HOH D 3 .   ? 12.53735  17.50926  -42.75722 1.000 36.32535 ? 547 HOH A O   1 
HETATM 4770 O  O   . HOH D 3 .   ? 17.77339  -1.59808  -44.12330 1.000 22.61377 ? 548 HOH A O   1 
HETATM 4771 O  O   . HOH D 3 .   ? 15.75423  11.73710  -50.87440 1.000 25.36910 ? 549 HOH A O   1 
HETATM 4772 O  O   . HOH D 3 .   ? -12.38670 20.33899  -12.54891 1.000 35.42439 ? 550 HOH A O   1 
HETATM 4773 O  O   . HOH D 3 .   ? 9.36720   17.67968  -29.34507 1.000 29.81036 ? 551 HOH A O   1 
HETATM 4774 O  O   . HOH D 3 .   ? -36.30870 7.64847   -15.30179 1.000 35.16662 ? 552 HOH A O   1 
HETATM 4775 O  O   . HOH D 3 .   ? 16.149    7.849     -53.044   1.000 29.30436 ? 553 HOH A O   1 
HETATM 4776 O  O   . HOH D 3 .   ? 21.468    -6.943    -38.356   1.000 26.06661 ? 554 HOH A O   1 
HETATM 4777 O  O   . HOH D 3 .   ? 11.94447  1.46090   -52.37874 1.000 32.49693 ? 555 HOH A O   1 
HETATM 4778 O  O   . HOH D 3 .   ? 20.32215  -4.00823  -32.74546 1.000 25.80900 ? 556 HOH A O   1 
HETATM 4779 O  O   . HOH D 3 .   ? 15.55656  -0.77435  -42.46613 1.000 19.03951 ? 557 HOH A O   1 
HETATM 4780 O  O   . HOH D 3 .   ? 10.33671  22.57285  -34.70675 1.000 32.68007 ? 558 HOH A O   1 
HETATM 4781 O  O   . HOH D 3 .   ? -8.88414  13.14979  -11.71291 1.000 19.95268 ? 559 HOH A O   1 
HETATM 4782 O  O   . HOH D 3 .   ? -0.61197  13.71726  -25.71853 1.000 34.57119 ? 560 HOH A O   1 
HETATM 4783 O  O   . HOH D 3 .   ? -8.84415  14.20691  -24.93251 1.000 25.07777 ? 561 HOH A O   1 
HETATM 4784 O  O   . HOH D 3 .   ? 15.463    -5.267    -43.000   1.000 19.59660 ? 562 HOH A O   1 
HETATM 4785 O  O   . HOH D 3 .   ? -4.67657  1.43740   -28.60699 1.000 19.38234 ? 563 HOH A O   1 
HETATM 4786 O  O   . HOH D 3 .   ? -15.64051 5.70534   -17.84016 1.000 18.72247 ? 564 HOH A O   1 
HETATM 4787 O  O   . HOH D 3 .   ? -22.66752 15.95230  -27.31377 1.000 23.82996 ? 565 HOH A O   1 
HETATM 4788 O  O   . HOH D 3 .   ? -29.76666 -0.78225  -42.57392 1.000 24.74358 ? 566 HOH A O   1 
HETATM 4789 O  O   . HOH D 3 .   ? 17.61171  5.01931   -47.07929 1.000 23.39595 ? 567 HOH A O   1 
HETATM 4790 O  O   . HOH D 3 .   ? 0.31077   15.11148  -16.55469 1.000 45.25803 ? 568 HOH A O   1 
HETATM 4791 O  O   . HOH D 3 .   ? -26.24453 1.97562   -37.31099 1.000 26.30778 ? 569 HOH A O   1 
HETATM 4792 O  O   . HOH D 3 .   ? -16.02423 14.06925  -10.55471 1.000 30.57886 ? 570 HOH A O   1 
HETATM 4793 O  O   . HOH D 3 .   ? -29.78933 1.56616   -14.23879 1.000 29.42996 ? 571 HOH A O   1 
HETATM 4794 O  O   . HOH D 3 .   ? -18.65864 -0.08566  -41.48428 1.000 33.42656 ? 572 HOH A O   1 
HETATM 4795 O  O   . HOH D 3 .   ? -34.41266 8.78327   -6.30095  1.000 43.95798 ? 573 HOH A O   1 
HETATM 4796 O  O   . HOH D 3 .   ? 25.69607  11.54810  -41.01589 1.000 38.13864 ? 574 HOH A O   1 
HETATM 4797 O  O   . HOH D 3 .   ? -18.14587 22.22976  -15.66195 1.000 33.61513 ? 575 HOH A O   1 
HETATM 4798 O  O   . HOH D 3 .   ? 19.01173  14.85395  -44.44293 1.000 34.99434 ? 576 HOH A O   1 
HETATM 4799 O  O   . HOH D 3 .   ? -7.26598  15.39911  -11.88049 1.000 39.25002 ? 577 HOH A O   1 
HETATM 4800 O  O   . HOH D 3 .   ? 18.038    10.371    -51.652   1.000 26.03585 ? 578 HOH A O   1 
HETATM 4801 O  O   . HOH D 3 .   ? 5.85288   -1.72951  -32.54543 1.000 40.42726 ? 579 HOH A O   1 
HETATM 4802 O  O   . HOH D 3 .   ? -28.79229 10.18674  -34.66726 1.000 32.23773 ? 580 HOH A O   1 
HETATM 4803 O  O   . HOH D 3 .   ? -33.61106 12.62253  -30.68954 1.000 34.31199 ? 581 HOH A O   1 
HETATM 4804 O  O   . HOH D 3 .   ? 21.13664  0.76166   -33.87181 1.000 25.18209 ? 582 HOH A O   1 
HETATM 4805 O  O   . HOH D 3 .   ? 20.43196  4.50443   -40.88083 1.000 20.70819 ? 583 HOH A O   1 
HETATM 4806 O  O   . HOH D 3 .   ? 0.91507   7.89136   -23.22283 1.000 23.39652 ? 584 HOH A O   1 
HETATM 4807 O  O   . HOH D 3 .   ? 5.34583   16.77601  -45.12889 1.000 37.97707 ? 585 HOH A O   1 
HETATM 4808 O  O   . HOH D 3 .   ? -6.34623  -2.45659  -34.62221 1.000 33.77046 ? 586 HOH A O   1 
HETATM 4809 O  O   . HOH D 3 .   ? -4.90121  7.54012   -39.74978 1.000 29.64433 ? 587 HOH A O   1 
HETATM 4810 O  O   . HOH D 3 .   ? 5.80851   6.12781   -28.25279 1.000 18.77046 ? 588 HOH A O   1 
HETATM 4811 O  O   . HOH D 3 .   ? -13.60956 3.67226   -33.27677 1.000 19.09414 ? 589 HOH A O   1 
HETATM 4812 O  O   . HOH D 3 .   ? -28.20437 13.55433  -34.53757 1.000 36.67929 ? 590 HOH A O   1 
HETATM 4813 O  O   . HOH D 3 .   ? 14.74564  15.61984  -46.13124 1.000 29.05542 ? 591 HOH A O   1 
HETATM 4814 O  O   . HOH D 3 .   ? 9.26900   -3.23479  -32.60540 1.000 26.80011 ? 592 HOH A O   1 
HETATM 4815 O  O   . HOH D 3 .   ? -10.21124 11.52763  -35.97554 1.000 25.73158 ? 593 HOH A O   1 
HETATM 4816 O  O   . HOH D 3 .   ? -10.09016 1.26293   -40.17302 1.000 32.07833 ? 594 HOH A O   1 
HETATM 4817 O  O   . HOH D 3 .   ? -12.96491 9.12842   -38.40820 1.000 32.59871 ? 595 HOH A O   1 
HETATM 4818 O  O   . HOH D 3 .   ? -33.16447 -2.40223  -24.84640 1.000 34.53017 ? 596 HOH A O   1 
HETATM 4819 O  O   . HOH D 3 .   ? -6.16616  -1.90465  -44.78495 1.000 44.83834 ? 597 HOH A O   1 
HETATM 4820 O  O   . HOH D 3 .   ? 11.84956  21.53040  -38.11460 1.000 35.75433 ? 598 HOH A O   1 
HETATM 4821 O  O   . HOH D 3 .   ? 3.28244   18.18814  -42.75485 1.000 37.15839 ? 599 HOH A O   1 
HETATM 4822 O  O   . HOH D 3 .   ? -17.70215 9.42946   -38.33229 1.000 30.51226 ? 600 HOH A O   1 
HETATM 4823 O  O   . HOH D 3 .   ? 12.37710  20.02822  -36.13730 1.000 36.57148 ? 601 HOH A O   1 
HETATM 4824 O  O   . HOH D 3 .   ? 16.16386  18.36293  -36.41694 1.000 35.14968 ? 602 HOH A O   1 
HETATM 4825 O  O   . HOH D 3 .   ? -20.86272 8.11108   -36.52996 1.000 24.50885 ? 603 HOH A O   1 
HETATM 4826 O  O   . HOH D 3 .   ? -29.74609 16.77258  -29.22400 1.000 43.03377 ? 604 HOH A O   1 
HETATM 4827 O  O   . HOH D 3 .   ? -15.10752 5.33763   -7.83254  1.000 39.41778 ? 605 HOH A O   1 
HETATM 4828 O  O   . HOH D 3 .   ? -43.29653 4.43551   -24.19291 1.000 34.78436 ? 606 HOH A O   1 
HETATM 4829 O  O   . HOH D 3 .   ? 19.79810  6.05646   -42.89242 1.000 24.12994 ? 607 HOH A O   1 
HETATM 4830 O  O   . HOH D 3 .   ? -41.24047 12.52077  -17.61611 1.000 40.31651 ? 608 HOH A O   1 
HETATM 4831 O  O   . HOH D 3 .   ? -7.77144  -4.79795  -27.81938 1.000 28.33290 ? 609 HOH A O   1 
HETATM 4832 O  O   . HOH D 3 .   ? 2.80253   0.07936   -28.56721 1.000 28.57157 ? 610 HOH A O   1 
HETATM 4833 O  O   . HOH D 3 .   ? -16.95999 -10.11365 -22.33322 1.000 31.80160 ? 611 HOH A O   1 
HETATM 4834 O  O   . HOH D 3 .   ? 1.82678   7.83288   -20.53321 1.000 26.30868 ? 612 HOH A O   1 
HETATM 4835 O  O   . HOH D 3 .   ? 8.51808   -5.85511  -25.12484 1.000 27.94376 ? 613 HOH A O   1 
HETATM 4836 O  O   . HOH D 3 .   ? -1.67997  2.48862   -18.31433 1.000 30.78610 ? 614 HOH A O   1 
HETATM 4837 O  O   . HOH D 3 .   ? -24.68212 1.97450   -42.04876 1.000 33.44105 ? 615 HOH A O   1 
HETATM 4838 O  O   . HOH D 3 .   ? 22.41596  15.79615  -39.87199 1.000 46.86202 ? 616 HOH A O   1 
HETATM 4839 O  O   . HOH D 3 .   ? 12.93791  20.55115  -41.02669 1.000 43.91627 ? 617 HOH A O   1 
HETATM 4840 O  O   . HOH D 3 .   ? 8.06833   11.65537  -47.90199 1.000 28.46300 ? 618 HOH A O   1 
HETATM 4841 O  O   . HOH D 3 .   ? 13.28878  14.33540  -48.38986 1.000 26.79060 ? 619 HOH A O   1 
HETATM 4842 O  O   . HOH D 3 .   ? 8.77261   1.87573   -22.71283 1.000 31.97378 ? 620 HOH A O   1 
HETATM 4843 O  O   . HOH D 3 .   ? -35.35533 -1.19674  -35.46960 1.000 35.45079 ? 621 HOH A O   1 
HETATM 4844 O  O   . HOH D 3 .   ? -26.92310 -3.33572  -26.65935 1.000 33.20479 ? 622 HOH A O   1 
HETATM 4845 O  O   . HOH D 3 .   ? 23.85448  13.93228  -28.47438 1.000 38.33173 ? 623 HOH A O   1 
HETATM 4846 O  O   . HOH D 3 .   ? -24.57835 2.93522   -30.02433 1.000 21.29667 ? 624 HOH A O   1 
HETATM 4847 O  O   . HOH D 3 .   ? -12.12545 18.80396  -31.14220 1.000 38.12911 ? 625 HOH A O   1 
HETATM 4848 O  O   . HOH D 3 .   ? -13.46837 20.96065  -29.08471 1.000 49.14008 ? 626 HOH A O   1 
HETATM 4849 O  O   . HOH D 3 .   ? -21.26468 5.77856   -37.80571 1.000 24.37937 ? 627 HOH A O   1 
HETATM 4850 O  O   . HOH D 3 .   ? -31.05668 4.32245   -37.52932 1.000 28.73404 ? 628 HOH A O   1 
HETATM 4851 O  O   . HOH D 3 .   ? -22.06903 -1.69863  -9.93954  1.000 35.85137 ? 629 HOH A O   1 
HETATM 4852 O  O   . HOH D 3 .   ? -23.43519 4.34416   -37.09298 1.000 30.13204 ? 630 HOH A O   1 
HETATM 4853 O  O   . HOH D 3 .   ? -6.93846  11.84416  -39.86931 1.000 43.08808 ? 631 HOH A O   1 
HETATM 4854 O  O   . HOH D 3 .   ? -35.91136 12.28186  -28.80119 1.000 34.26434 ? 632 HOH A O   1 
HETATM 4855 O  O   . HOH D 3 .   ? -25.04049 2.87775   -9.83972  1.000 36.44188 ? 633 HOH A O   1 
HETATM 4856 O  O   . HOH D 3 .   ? 13.80062  22.26303  -26.10899 1.000 42.17195 ? 634 HOH A O   1 
HETATM 4857 O  O   . HOH D 3 .   ? 16.34505  17.03838  -38.91738 1.000 27.44159 ? 635 HOH A O   1 
HETATM 4858 O  O   . HOH D 3 .   ? 3.78370   9.25863   -37.79051 1.000 21.24548 ? 636 HOH A O   1 
HETATM 4859 O  O   . HOH D 3 .   ? -27.16024 -5.84694  -19.19904 1.000 39.15061 ? 637 HOH A O   1 
HETATM 4860 O  O   . HOH D 3 .   ? 21.07177  -1.88233  -34.21429 1.000 27.02366 ? 638 HOH A O   1 
HETATM 4861 O  O   . HOH D 3 .   ? -22.95798 4.60951   -10.39672 1.000 33.24819 ? 639 HOH A O   1 
HETATM 4862 O  O   . HOH D 3 .   ? -27.06001 19.60693  -7.83155  1.000 39.66520 ? 640 HOH A O   1 
HETATM 4863 O  O   . HOH D 3 .   ? 4.33755   0.85488   -18.25910 1.000 33.32147 ? 641 HOH A O   1 
HETATM 4864 O  O   . HOH D 3 .   ? 22.24849  10.62622  -23.54769 1.000 34.02948 ? 642 HOH A O   1 
HETATM 4865 O  O   . HOH D 3 .   ? -23.21536 -5.18333  -16.93719 1.000 43.11701 ? 643 HOH A O   1 
HETATM 4866 O  O   . HOH D 3 .   ? -29.42502 -5.88907  -16.88434 1.000 40.12070 ? 644 HOH A O   1 
HETATM 4867 O  O   . HOH D 3 .   ? 2.71921   -0.89365  -33.54653 1.000 34.72190 ? 645 HOH A O   1 
HETATM 4868 O  O   . HOH D 3 .   ? -22.76823 19.35323  -29.60373 1.000 42.20267 ? 646 HOH A O   1 
HETATM 4869 O  O   . HOH D 3 .   ? 1.28516   -2.40461  -34.57306 1.000 41.51788 ? 647 HOH A O   1 
HETATM 4870 O  O   . HOH D 3 .   ? 23.15514  -6.45777  -35.70650 1.000 34.66782 ? 648 HOH A O   1 
HETATM 4871 O  O   . HOH D 3 .   ? -11.85153 11.29438  -37.85060 1.000 38.48518 ? 649 HOH A O   1 
HETATM 4872 O  O   . HOH D 3 .   ? -33.53567 6.53912   -5.29541  1.000 43.15054 ? 650 HOH A O   1 
HETATM 4873 O  O   . HOH D 3 .   ? -30.83772 -2.05309  -13.21895 1.000 49.72954 ? 651 HOH A O   1 
HETATM 4874 O  O   . HOH D 3 .   ? 19.87254  7.58176   -45.81726 1.000 22.24918 ? 652 HOH A O   1 
HETATM 4875 O  O   . HOH D 3 .   ? -28.41334 5.01379   -38.12328 1.000 36.22732 ? 653 HOH A O   1 
HETATM 4876 O  O   . HOH D 3 .   ? 0.06956   11.16500  -35.19005 1.000 33.95181 ? 654 HOH A O   1 
HETATM 4877 O  O   . HOH D 3 .   ? -0.05988  14.88507  -27.88690 1.000 40.02592 ? 655 HOH A O   1 
HETATM 4878 O  O   . HOH D 3 .   ? -21.66862 16.62497  -35.19473 1.000 38.92611 ? 656 HOH A O   1 
HETATM 4879 O  O   . HOH D 3 .   ? 13.34552  11.37690  -17.11347 1.000 42.64107 ? 657 HOH A O   1 
HETATM 4880 O  O   . HOH D 3 .   ? -14.38282 10.55567  -7.31438  1.000 34.77790 ? 658 HOH A O   1 
HETATM 4881 O  O   . HOH D 3 .   ? -37.87964 14.19076  -24.77088 1.000 33.03481 ? 659 HOH A O   1 
HETATM 4882 O  O   . HOH D 3 .   ? 9.10016   8.81292   -53.48046 1.000 37.26722 ? 660 HOH A O   1 
HETATM 4883 O  O   . HOH D 3 .   ? -27.98323 17.97690  -30.26703 1.000 50.66500 ? 661 HOH A O   1 
HETATM 4884 O  O   . HOH D 3 .   ? 24.85592  12.70859  -30.72239 1.000 36.00547 ? 662 HOH A O   1 
HETATM 4885 O  O   . HOH D 3 .   ? -17.00705 23.09123  -17.97768 1.000 34.68825 ? 663 HOH A O   1 
HETATM 4886 O  O   . HOH D 3 .   ? -24.33146 17.30045  -34.34007 1.000 43.86196 ? 664 HOH A O   1 
HETATM 4887 O  O   . HOH D 3 .   ? 4.12693   -1.32564  -29.76723 1.000 37.29853 ? 665 HOH A O   1 
HETATM 4888 O  O   . HOH D 3 .   ? 2.24397   15.57796  -29.52168 1.000 32.24436 ? 666 HOH A O   1 
HETATM 4889 O  O   . HOH D 3 .   ? 7.10808   2.71401   -49.20672 1.000 37.13158 ? 667 HOH A O   1 
HETATM 4890 O  O   . HOH D 3 .   ? -22.87157 0.92585   -43.95788 1.000 43.59868 ? 668 HOH A O   1 
HETATM 4891 O  O   . HOH D 3 .   ? -18.33806 -8.45906  -29.41889 1.000 39.74059 ? 669 HOH A O   1 
HETATM 4892 O  O   . HOH D 3 .   ? -16.24526 16.48061  -29.72340 1.000 35.34252 ? 670 HOH A O   1 
HETATM 4893 O  O   . HOH D 3 .   ? -15.05721 13.37369  -7.91622  1.000 37.15970 ? 671 HOH A O   1 
HETATM 4894 O  O   . HOH D 3 .   ? -2.65932  9.06746   -39.36039 1.000 36.60878 ? 672 HOH A O   1 
HETATM 4895 O  O   . HOH D 3 .   ? 5.82141   0.55230   -48.62120 1.000 37.65451 ? 673 HOH A O   1 
HETATM 4896 O  O   . HOH D 3 .   ? 2.40315   -3.75612  -38.05416 1.000 44.75664 ? 674 HOH A O   1 
HETATM 4897 O  O   . HOH D 3 .   ? -15.24624 9.36415   -39.41250 1.000 37.19869 ? 675 HOH A O   1 
HETATM 4898 O  O   . HOH D 3 .   ? -2.153    21.734    -22.345   1.000 47.76058 ? 676 HOH A O   1 
HETATM 4899 O  O   . HOH D 3 .   ? 20.33505  -2.64661  -23.20912 1.000 38.32307 ? 677 HOH A O   1 
HETATM 4900 O  O   . HOH D 3 .   ? 23.72700  -2.46045  -33.77291 1.000 40.32055 ? 678 HOH A O   1 
HETATM 4901 O  O   . HOH D 3 .   ? -38.27078 -0.31445  -22.88527 1.000 45.06973 ? 679 HOH A O   1 
HETATM 4902 O  O   . HOH D 3 .   ? -26.53871 18.30464  -33.38789 1.000 48.24786 ? 680 HOH A O   1 
HETATM 4903 O  O   . HOH D 3 .   ? 13.18552  17.53120  -45.01537 1.000 34.65018 ? 681 HOH A O   1 
HETATM 4904 O  O   . HOH D 3 .   ? 6.60527   -3.49522  -36.84463 1.000 40.15351 ? 682 HOH A O   1 
HETATM 4905 O  O   . HOH D 3 .   ? -35.38930 -1.95820  -24.86023 1.000 35.96552 ? 683 HOH A O   1 
HETATM 4906 O  O   . HOH D 3 .   ? 25.83697  11.92092  -36.66478 1.000 45.20209 ? 684 HOH A O   1 
HETATM 4907 O  O   . HOH D 3 .   ? -22.62807 18.11601  -26.59319 1.000 39.54033 ? 685 HOH A O   1 
HETATM 4908 O  O   . HOH D 3 .   ? -3.23679  16.33560  -14.41713 1.000 40.71219 ? 686 HOH A O   1 
HETATM 4909 O  O   . HOH D 3 .   ? 10.626    7.528     -54.781   1.000 33.87747 ? 687 HOH A O   1 
HETATM 4910 O  O   . HOH D 3 .   ? 27.75804  8.50813   -43.33798 1.000 45.23906 ? 688 HOH A O   1 
HETATM 4911 O  O   . HOH D 3 .   ? -25.47777 4.11566   -39.10574 1.000 40.18802 ? 689 HOH A O   1 
HETATM 4912 O  O   . HOH D 3 .   ? -37.71902 11.02147  -30.07180 1.000 36.71792 ? 690 HOH A O   1 
HETATM 4913 O  O   . HOH D 3 .   ? -29.63216 0.97881   -41.02139 1.000 41.05006 ? 691 HOH A O   1 
HETATM 4914 O  O   . HOH D 3 .   ? 1.09701   9.09670   -37.26322 1.000 30.85948 ? 692 HOH A O   1 
HETATM 4915 O  O   . HOH D 3 .   ? 20.97086  13.63701  -46.32250 1.000 37.77250 ? 693 HOH A O   1 
HETATM 4916 O  O   . HOH D 3 .   ? 20.098    11.740    -50.789   1.000 30.22139 ? 694 HOH A O   1 
HETATM 4917 O  O   . HOH D 3 .   ? 17.23727  16.37076  -45.84145 1.000 36.85628 ? 695 HOH A O   1 
HETATM 4918 O  O   . HOH D 3 .   ? -21.22529 -0.77936  -43.95301 1.000 46.57791 ? 696 HOH A O   1 
HETATM 4919 O  O   . HOH D 3 .   ? 14.29349  18.31520  -41.22387 1.000 34.42409 ? 697 HOH A O   1 
HETATM 4920 O  O   . HOH D 3 .   ? 9.19051   -3.93841  -37.57943 1.000 38.77913 ? 698 HOH A O   1 
HETATM 4921 O  O   . HOH D 3 .   ? -34.64626 10.88245  -32.73614 1.000 33.10939 ? 699 HOH A O   1 
HETATM 4922 O  O   . HOH D 3 .   ? -9.95326  3.60967   -42.12767 1.000 34.00000 ? 700 HOH A O   1 
HETATM 4923 O  O   . HOH D 3 .   ? 1.84765   14.89662  -32.22599 1.000 40.25346 ? 701 HOH A O   1 
HETATM 4924 O  O   . HOH D 3 .   ? -32.75764 19.51196  -30.87927 1.000 48.21348 ? 702 HOH A O   1 
HETATM 4925 O  O   . HOH D 3 .   ? -32.11413 19.05472  -33.74241 1.000 46.97044 ? 703 HOH A O   1 
HETATM 4926 O  O   . HOH E 3 .   ? 14.95565  -5.17540  -11.48150 1.000 40.85571 ? 401 HOH B O   1 
HETATM 4927 O  O   . HOH E 3 .   ? 3.88284   -8.61754  4.71233   1.000 42.46343 ? 402 HOH B O   1 
HETATM 4928 O  O   . HOH E 3 .   ? -1.83067  7.04896   12.33106  1.000 35.56938 ? 403 HOH B O   1 
HETATM 4929 O  O   . HOH E 3 .   ? 6.20683   10.78988  -12.24182 1.000 32.96670 ? 404 HOH B O   1 
HETATM 4930 O  O   . HOH E 3 .   ? 2.28817   -28.18581 -21.91471 1.000 37.18773 ? 405 HOH B O   1 
HETATM 4931 O  O   . HOH E 3 .   ? 0.052     -36.816   -30.658   1.000 42.41841 ? 406 HOH B O   1 
HETATM 4932 O  O   . HOH E 3 .   ? 12.37034  -13.69589 -18.83857 1.000 30.03324 ? 407 HOH B O   1 
HETATM 4933 O  O   . HOH E 3 .   ? 3.41174   -30.18942 -27.98381 1.000 39.32699 ? 408 HOH B O   1 
HETATM 4934 O  O   . HOH E 3 .   ? -11.817   8.208     9.206     1.000 24.07934 ? 409 HOH B O   1 
HETATM 4935 O  O   . HOH E 3 .   ? 9.85107   -12.13544 -30.55719 1.000 42.40563 ? 410 HOH B O   1 
HETATM 4936 O  O   . HOH E 3 .   ? 24.46393  11.55774  16.16609  1.000 49.35917 ? 411 HOH B O   1 
HETATM 4937 O  O   . HOH E 3 .   ? 1.70296   -26.05829 -22.39333 1.000 33.05467 ? 412 HOH B O   1 
HETATM 4938 O  O   . HOH E 3 .   ? -10.70897 10.59686  -1.09550  1.000 29.20456 ? 413 HOH B O   1 
HETATM 4939 O  O   . HOH E 3 .   ? 6.16381   -25.33761 -2.13976  1.000 40.41267 ? 414 HOH B O   1 
HETATM 4940 O  O   . HOH E 3 .   ? 1.61546   0.25793   5.12806   1.000 23.49637 ? 415 HOH B O   1 
HETATM 4941 O  O   . HOH E 3 .   ? 8.995     -33.401   -17.763   1.000 40.15597 ? 416 HOH B O   1 
HETATM 4942 O  O   . HOH E 3 .   ? -4.61949  9.56011   10.02690  1.000 23.97163 ? 417 HOH B O   1 
HETATM 4943 O  O   . HOH E 3 .   ? 15.25157  -2.74239  5.53144   1.000 23.89123 ? 418 HOH B O   1 
HETATM 4944 O  O   . HOH E 3 .   ? -6.94331  17.69335  14.76615  1.000 37.81758 ? 419 HOH B O   1 
HETATM 4945 O  O   . HOH E 3 .   ? 13.97202  -26.89840 -25.16636 1.000 43.10937 ? 420 HOH B O   1 
HETATM 4946 O  O   . HOH E 3 .   ? 11.483    -0.098    11.324    1.000 21.05192 ? 421 HOH B O   1 
HETATM 4947 O  O   . HOH E 3 .   ? -7.20426  -19.69400 -26.39932 1.000 42.93540 ? 422 HOH B O   1 
HETATM 4948 O  O   . HOH E 3 .   ? 15.26742  -13.09108 -14.73009 1.000 35.58075 ? 423 HOH B O   1 
HETATM 4949 O  O   . HOH E 3 .   ? 17.96234  -19.09923 -24.08301 1.000 52.29283 ? 424 HOH B O   1 
HETATM 4950 O  O   . HOH E 3 .   ? 2.76919   -12.35955 -7.13702  1.000 22.64176 ? 425 HOH B O   1 
HETATM 4951 O  O   . HOH E 3 .   ? -14.91666 6.51468   -4.72788  1.000 41.45637 ? 426 HOH B O   1 
HETATM 4952 O  O   . HOH E 3 .   ? -12.31961 -12.65712 -20.03781 1.000 41.40377 ? 427 HOH B O   1 
HETATM 4953 O  O   . HOH E 3 .   ? 0.19725   9.58554   -4.05968  1.000 26.95092 ? 428 HOH B O   1 
HETATM 4954 O  O   . HOH E 3 .   ? 6.68081   18.34229  -4.80947  1.000 35.74610 ? 429 HOH B O   1 
HETATM 4955 O  O   . HOH E 3 .   ? 8.32488   -2.35936  -10.36761 1.000 21.34490 ? 430 HOH B O   1 
HETATM 4956 O  O   . HOH E 3 .   ? -10.75619 5.71788   -6.02463  1.000 31.31517 ? 431 HOH B O   1 
HETATM 4957 O  O   . HOH E 3 .   ? 23.29325  -7.07841  -9.58056  1.000 43.82754 ? 432 HOH B O   1 
HETATM 4958 O  O   . HOH E 3 .   ? -6.551    -29.338   -21.729   1.000 36.51927 ? 433 HOH B O   1 
HETATM 4959 O  O   . HOH E 3 .   ? 9.49299   -15.13914 -4.65828  1.000 38.63569 ? 434 HOH B O   1 
HETATM 4960 O  O   . HOH E 3 .   ? 2.38252   5.88743   10.34313  1.000 29.26684 ? 435 HOH B O   1 
HETATM 4961 O  O   . HOH E 3 .   ? 12.34174  -11.50340 -2.56246  1.000 34.11056 ? 436 HOH B O   1 
HETATM 4962 O  O   . HOH E 3 .   ? -2.72340  -8.77799  -6.71982  1.000 22.90174 ? 437 HOH B O   1 
HETATM 4963 O  O   . HOH E 3 .   ? 16.58269  -0.45798  6.28639   1.000 26.57408 ? 438 HOH B O   1 
HETATM 4964 O  O   . HOH E 3 .   ? 17.79984  9.53206   22.15715  1.000 39.45147 ? 439 HOH B O   1 
HETATM 4965 O  O   . HOH E 3 .   ? -10.11683 17.43862  1.51044   1.000 33.72573 ? 440 HOH B O   1 
HETATM 4966 O  O   . HOH E 3 .   ? -7.57806  13.49568  16.85008  1.000 44.43374 ? 441 HOH B O   1 
HETATM 4967 O  O   . HOH E 3 .   ? 14.48948  15.78780  1.51213   1.000 37.49908 ? 442 HOH B O   1 
HETATM 4968 O  O   . HOH E 3 .   ? 11.87092  -0.07799  -1.41919  1.000 18.98554 ? 443 HOH B O   1 
HETATM 4969 O  O   . HOH E 3 .   ? 9.22334   -31.64956 -8.00104  1.000 47.84128 ? 444 HOH B O   1 
HETATM 4970 O  O   . HOH E 3 .   ? -10.49248 -8.44798  -21.64696 1.000 27.94794 ? 445 HOH B O   1 
HETATM 4971 O  O   . HOH E 3 .   ? 9.60812   -18.02339 -4.44168  1.000 38.96817 ? 446 HOH B O   1 
HETATM 4972 O  O   . HOH E 3 .   ? 12.95283  9.56264   4.87026   1.000 21.50230 ? 447 HOH B O   1 
HETATM 4973 O  O   . HOH E 3 .   ? -2.83461  -4.74642  -7.66500  1.000 22.97871 ? 448 HOH B O   1 
HETATM 4974 O  O   . HOH E 3 .   ? -1.95557  -2.58190  -0.56402  1.000 25.42644 ? 449 HOH B O   1 
HETATM 4975 O  O   . HOH E 3 .   ? 7.43491   -6.84936  -16.42636 1.000 34.48232 ? 450 HOH B O   1 
HETATM 4976 O  O   . HOH E 3 .   ? -14.13877 -10.50489 -23.61467 1.000 39.39996 ? 451 HOH B O   1 
HETATM 4977 O  O   . HOH E 3 .   ? -13.89522 -12.31731 -10.18748 1.000 42.85694 ? 452 HOH B O   1 
HETATM 4978 O  O   . HOH E 3 .   ? -9.13430  -6.08082  -5.47878  1.000 44.59254 ? 453 HOH B O   1 
HETATM 4979 O  O   . HOH E 3 .   ? 4.99239   -18.99482 -1.81662  1.000 33.20778 ? 454 HOH B O   1 
HETATM 4980 O  O   . HOH E 3 .   ? -6.76980  14.99890  -8.44837  1.000 30.85717 ? 455 HOH B O   1 
HETATM 4981 O  O   . HOH E 3 .   ? -11.64223 18.99397  11.61066  1.000 40.26543 ? 456 HOH B O   1 
HETATM 4982 O  O   . HOH E 3 .   ? 11.81711  -35.80613 -14.64551 1.000 37.09302 ? 457 HOH B O   1 
HETATM 4983 O  O   . HOH E 3 .   ? -16.70581 2.41189   -3.86109  1.000 37.21642 ? 458 HOH B O   1 
HETATM 4984 O  O   . HOH E 3 .   ? 1.21807   -7.88357  -22.11049 1.000 31.93789 ? 459 HOH B O   1 
HETATM 4985 O  O   . HOH E 3 .   ? -2.32249  -26.97800 -12.05526 1.000 39.83341 ? 460 HOH B O   1 
HETATM 4986 O  O   . HOH E 3 .   ? -11.70425 6.02792   7.29195   1.000 32.89864 ? 461 HOH B O   1 
HETATM 4987 O  O   . HOH E 3 .   ? 0.93455   -11.09578 -29.29910 1.000 32.43691 ? 462 HOH B O   1 
HETATM 4988 O  O   . HOH E 3 .   ? 11.50949  -11.97673 -21.25783 1.000 30.58046 ? 463 HOH B O   1 
HETATM 4989 O  O   . HOH E 3 .   ? 2.72542   -10.94664 -15.10929 1.000 20.16332 ? 464 HOH B O   1 
HETATM 4990 O  O   . HOH E 3 .   ? -0.96160  -12.69288 -31.35308 1.000 43.72405 ? 465 HOH B O   1 
HETATM 4991 O  O   . HOH E 3 .   ? 23.69707  16.55806  10.20450  1.000 48.26394 ? 466 HOH B O   1 
HETATM 4992 O  O   . HOH E 3 .   ? -1.56881  -0.87466  11.28011  1.000 39.52331 ? 467 HOH B O   1 
HETATM 4993 O  O   . HOH E 3 .   ? 14.41510  -13.38217 -3.86750  1.000 35.10714 ? 468 HOH B O   1 
HETATM 4994 O  O   . HOH E 3 .   ? 0.22409   -5.72064  6.56683   1.000 27.84976 ? 469 HOH B O   1 
HETATM 4995 O  O   . HOH E 3 .   ? 3.44730   -10.63194 -33.36571 1.000 47.44082 ? 470 HOH B O   1 
HETATM 4996 O  O   . HOH E 3 .   ? 3.89149   -2.56391  8.44036   1.000 29.97616 ? 471 HOH B O   1 
HETATM 4997 O  O   . HOH E 3 .   ? 0.62986   5.40203   11.86834  1.000 33.02543 ? 472 HOH B O   1 
HETATM 4998 O  O   . HOH E 3 .   ? -3.06734  -4.58105  -13.95237 1.000 18.38548 ? 473 HOH B O   1 
HETATM 4999 O  O   . HOH E 3 .   ? -5.07051  -6.42641  -13.96405 1.000 23.64393 ? 474 HOH B O   1 
HETATM 5000 O  O   . HOH E 3 .   ? 19.69889  7.58257   20.05841  1.000 35.46037 ? 475 HOH B O   1 
HETATM 5001 O  O   . HOH E 3 .   ? -1.60370  22.41189  -3.07246  1.000 47.21141 ? 476 HOH B O   1 
HETATM 5002 O  O   . HOH E 3 .   ? 9.09694   1.92079   15.81300  1.000 32.02725 ? 477 HOH B O   1 
HETATM 5003 O  O   . HOH E 3 .   ? 12.53583  2.81691   -12.52955 1.000 33.12239 ? 478 HOH B O   1 
HETATM 5004 O  O   . HOH E 3 .   ? 7.71963   -7.54093  2.59513   1.000 24.33091 ? 479 HOH B O   1 
HETATM 5005 O  O   . HOH E 3 .   ? 15.32534  -20.21610 -8.56273  1.000 40.31320 ? 480 HOH B O   1 
HETATM 5006 O  O   . HOH E 3 .   ? 22.72267  8.30498   9.72007   1.000 46.23378 ? 481 HOH B O   1 
HETATM 5007 O  O   . HOH E 3 .   ? -11.30221 -19.14397 -20.67431 1.000 45.90667 ? 482 HOH B O   1 
HETATM 5008 O  O   . HOH E 3 .   ? 12.32106  -5.59230  3.32762   1.000 19.34758 ? 483 HOH B O   1 
HETATM 5009 O  O   . HOH E 3 .   ? 1.80544   -1.09742  7.59183   1.000 25.69096 ? 484 HOH B O   1 
HETATM 5010 O  O   . HOH E 3 .   ? -1.36859  -17.73715 -30.87564 1.000 35.97091 ? 485 HOH B O   1 
HETATM 5011 O  O   . HOH E 3 .   ? -13.60472 -5.10277  -5.01766  1.000 39.38087 ? 486 HOH B O   1 
HETATM 5012 O  O   . HOH E 3 .   ? -11.58694 -5.42619  -16.16917 1.000 30.19905 ? 487 HOH B O   1 
HETATM 5013 O  O   . HOH E 3 .   ? 11.19310  -11.05382 -17.89148 1.000 39.25642 ? 488 HOH B O   1 
HETATM 5014 O  O   . HOH E 3 .   ? -2.60679  19.85717  -2.53025  1.000 38.42216 ? 489 HOH B O   1 
HETATM 5015 O  O   . HOH E 3 .   ? 7.29596   -16.98391 -8.25936  1.000 23.52277 ? 490 HOH B O   1 
HETATM 5016 O  O   . HOH E 3 .   ? 17.89578  -5.65853  -2.41519  1.000 27.86878 ? 491 HOH B O   1 
HETATM 5017 O  O   . HOH E 3 .   ? 16.53985  4.08182   7.32711   1.000 22.82065 ? 492 HOH B O   1 
HETATM 5018 O  O   . HOH E 3 .   ? 16.39123  -3.02507  -9.20270  1.000 34.32781 ? 493 HOH B O   1 
HETATM 5019 O  O   . HOH E 3 .   ? 10.07333  8.79471   17.44372  1.000 39.31546 ? 494 HOH B O   1 
HETATM 5020 O  O   . HOH E 3 .   ? -5.73656  -5.50827  2.33812   1.000 45.81079 ? 495 HOH B O   1 
HETATM 5021 O  O   . HOH E 3 .   ? -14.10895 4.85710   1.13861   1.000 26.76615 ? 496 HOH B O   1 
HETATM 5022 O  O   . HOH E 3 .   ? 10.96913  -32.11409 -17.01592 1.000 38.61127 ? 497 HOH B O   1 
HETATM 5023 O  O   . HOH E 3 .   ? -17.39744 -6.37373  -8.73063  1.000 39.23396 ? 498 HOH B O   1 
HETATM 5024 O  O   . HOH E 3 .   ? 20.92996  11.83450  19.62295  1.000 46.83712 ? 499 HOH B O   1 
HETATM 5025 O  O   . HOH E 3 .   ? -4.79875  30.03179  14.79748  1.000 54.94854 ? 500 HOH B O   1 
HETATM 5026 O  O   . HOH E 3 .   ? 0.95325   -14.02586 -31.27932 1.000 37.40398 ? 501 HOH B O   1 
HETATM 5027 O  O   . HOH E 3 .   ? 15.89224  -9.46739  -1.92341  1.000 29.48232 ? 502 HOH B O   1 
HETATM 5028 O  O   . HOH E 3 .   ? 8.80202   10.93340  17.54477  1.000 39.65191 ? 503 HOH B O   1 
HETATM 5029 O  O   . HOH E 3 .   ? 17.35785  9.25512   14.83195  1.000 38.00758 ? 504 HOH B O   1 
HETATM 5030 O  O   . HOH E 3 .   ? 10.66206  -8.03266  -15.26953 1.000 36.14514 ? 505 HOH B O   1 
HETATM 5031 O  O   . HOH E 3 .   ? -5.16915  16.78072  -4.18501  1.000 43.26319 ? 506 HOH B O   1 
HETATM 5032 O  O   . HOH E 3 .   ? 4.44819   -23.28198 -0.61279  1.000 39.15831 ? 507 HOH B O   1 
HETATM 5033 O  O   . HOH E 3 .   ? 26.26192  15.21422  7.92859   1.000 48.25736 ? 508 HOH B O   1 
HETATM 5034 O  O   . HOH E 3 .   ? 11.19274  14.64939  -3.73534  1.000 42.46670 ? 509 HOH B O   1 
HETATM 5035 O  O   . HOH E 3 .   ? 18.79741  -2.20286  -10.06567 1.000 41.94638 ? 510 HOH B O   1 
HETATM 5036 O  O   . HOH E 3 .   ? -1.21064  -7.51283  -5.02899  1.000 23.48018 ? 511 HOH B O   1 
HETATM 5037 O  O   . HOH E 3 .   ? 19.51331  -6.61106  -11.39035 1.000 46.65643 ? 512 HOH B O   1 
HETATM 5038 O  O   . HOH E 3 .   ? -0.40796  1.36445   -15.74860 1.000 26.37515 ? 513 HOH B O   1 
HETATM 5039 O  O   . HOH E 3 .   ? -10.81844 3.47389   7.87627   1.000 33.10336 ? 514 HOH B O   1 
HETATM 5040 O  O   . HOH E 3 .   ? 12.36905  -13.82046 -29.92560 1.000 42.78563 ? 515 HOH B O   1 
HETATM 5041 O  O   . HOH E 3 .   ? 23.49428  -5.18271  -3.13165  1.000 31.93397 ? 516 HOH B O   1 
HETATM 5042 O  O   . HOH E 3 .   ? 6.08471   -31.66660 -9.02573  1.000 48.01473 ? 517 HOH B O   1 
HETATM 5043 O  O   . HOH E 3 .   ? 10.39154  -12.89013 -4.05289  1.000 37.46948 ? 518 HOH B O   1 
HETATM 5044 O  O   . HOH E 3 .   ? 3.18398   -13.31558 -32.78510 1.000 46.17169 ? 519 HOH B O   1 
HETATM 5045 O  O   . HOH E 3 .   ? 18.99660  8.76781   13.23693  1.000 31.28372 ? 520 HOH B O   1 
HETATM 5046 O  O   . HOH E 3 .   ? -9.83029  18.08996  14.16587  1.000 40.57451 ? 521 HOH B O   1 
HETATM 5047 O  O   . HOH E 3 .   ? -19.06483 -7.06429  -14.22116 1.000 41.99456 ? 522 HOH B O   1 
HETATM 5048 O  O   . HOH E 3 .   ? 19.51305  -4.85208  -9.80225  1.000 41.10197 ? 523 HOH B O   1 
HETATM 5049 O  O   . HOH E 3 .   ? 12.29997  -5.74252  6.05315   1.000 23.40113 ? 524 HOH B O   1 
HETATM 5050 O  O   . HOH E 3 .   ? -9.73162  -12.19941 -28.36812 1.000 42.14998 ? 525 HOH B O   1 
HETATM 5051 O  O   . HOH E 3 .   ? 19.52689  14.36649  20.34670  1.000 46.97246 ? 526 HOH B O   1 
HETATM 5052 O  O   . HOH E 3 .   ? 1.66939   12.95490  15.53413  1.000 36.03143 ? 527 HOH B O   1 
HETATM 5053 O  O   . HOH E 3 .   ? -0.11051  -6.16027  -21.32760 1.000 37.37696 ? 528 HOH B O   1 
HETATM 5054 O  O   . HOH E 3 .   ? 8.51855   -30.95123 -5.51941  1.000 50.44057 ? 529 HOH B O   1 
HETATM 5055 O  O   . HOH E 3 .   ? -9.99982  -11.12257 -21.08694 1.000 33.42809 ? 530 HOH B O   1 
HETATM 5056 O  O   . HOH E 3 .   ? -9.67988  -12.31665 -8.48924  1.000 47.45166 ? 531 HOH B O   1 
HETATM 5057 O  O   . HOH E 3 .   ? 8.660     28.874    8.195     1.000 44.35415 ? 532 HOH B O   1 
HETATM 5058 O  O   . HOH E 3 .   ? 7.37938   -15.11280 -6.15594  1.000 34.53098 ? 533 HOH B O   1 
HETATM 5059 O  O   . HOH E 3 .   ? -11.61890 -11.94781 -29.93335 1.000 42.23394 ? 534 HOH B O   1 
HETATM 5060 O  O   . HOH E 3 .   ? 12.74886  -15.20147 -22.76886 1.000 45.62147 ? 535 HOH B O   1 
HETATM 5061 O  O   . HOH E 3 .   ? 13.72714  18.25068  -2.76399  1.000 43.76077 ? 536 HOH B O   1 
HETATM 5062 O  O   . HOH E 3 .   ? 4.93535   -13.71311 -5.53899  1.000 37.36755 ? 537 HOH B O   1 
HETATM 5063 O  O   . HOH E 3 .   ? 4.28309   -31.47601 -6.66607  1.000 45.13116 ? 538 HOH B O   1 
HETATM 5064 O  O   . HOH E 3 .   ? -3.27134  -4.90188  0.12272   1.000 35.83377 ? 539 HOH B O   1 
HETATM 5065 O  O   . HOH E 3 .   ? -9.45979  -20.05743 -22.43750 1.000 39.47372 ? 540 HOH B O   1 
HETATM 5066 O  O   . HOH E 3 .   ? 1.52858   -4.27597  -20.63165 1.000 38.00175 ? 541 HOH B O   1 
HETATM 5067 O  O   . HOH E 3 .   ? 23.129    7.110     12.492    1.000 36.92274 ? 542 HOH B O   1 
HETATM 5068 O  O   . HOH E 3 .   ? -0.22408  11.74041  15.32280  1.000 38.20809 ? 543 HOH B O   1 
HETATM 5069 O  O   . HOH E 3 .   ? 3.87103   -34.38954 -6.39365  1.000 49.87841 ? 544 HOH B O   1 
# 
