data_9BO0
# 
_entry.id   9BO0 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BO0         pdb_00009bo0 10.2210/pdb9bo0/pdb 
WWPDB D_1000283728 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-12 ? 
2 'Structure model' 1 1 2025-03-12 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
_pdbx_audit_revision_category.ordinal             1 
_pdbx_audit_revision_category.revision_ordinal    2 
_pdbx_audit_revision_category.data_content_type   'Structure model' 
_pdbx_audit_revision_category.category            citation 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
5 2 'Structure model' '_citation.title'                   
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BO0 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-03 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              karen.anderson@yale.edu 
_pdbx_contact_author.name_first         Karen 
_pdbx_contact_author.name_last          Anderson 
_pdbx_contact_author.name_mi            S 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-3433-0780 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Papini, C.'      1 0000-0002-6098-4959 
'Zhang, C.H.'     2 ?                   
'Jorgensen, W.L.' 3 ?                   
'Anderson, K.S.'  4 0000-0003-3433-0780 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Acs Bio Med Chem Au' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2694-2437 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            5 
_citation.language                  ? 
_citation.page_first                215 
_citation.page_last                 226 
_citation.title                     
'Exploring Possible Drug-Resistant Variants of SARS-CoV-2 Main Protease (M pro ) with Noncovalent Preclinical Candidate, Mpro61.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acsbiomedchemau.4c00109 
_citation.pdbx_database_id_PubMed   39990941 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Kenneson, J.R.'  1 ? 
primary 'Papini, C.'      2 ? 
primary 'Tang, S.'        3 ? 
primary 'Huynh, K.'       4 ? 
primary 'Zhang, C.H.'     5 ? 
primary 'Jorgensen, W.L.' 6 ? 
primary 'Anderson, K.S.'  7 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man '3C-like proteinase' 33837.602 2   3.4.22.69 ? ? ? 
2 non-polymer syn 
;(5P)-5-[(1P,3M,3'P)-3-{3-chloro-5-[(2-chlorophenyl)methoxy]-4-fluorophenyl}-2-oxo-2H-[1,3'-bipyridin]-5-yl]-1-methylpyrimidine-2,4(1H,3H)-dione
;
565.379   1   ?         ? ? ? 
3 water       nat water 18.015    138 ?         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        '3CL-PRO, 3CLp, Main protease, Mpro, Non-structural protein 5, nsp5, SARS coronavirus main proteinase' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SGFRKMAFPSGKVEGCMVQVICGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SGFRKMAFPSGKVEGCMVQVICGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 
;(5P)-5-[(1P,3M,3'P)-3-{3-chloro-5-[(2-chlorophenyl)methoxy]-4-fluorophenyl}-2-oxo-2H-[1,3'-bipyridin]-5-yl]-1-methylpyrimidine-2,4(1H,3H)-dione
;
XEK 
3 water HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   GLY n 
1 3   PHE n 
1 4   ARG n 
1 5   LYS n 
1 6   MET n 
1 7   ALA n 
1 8   PHE n 
1 9   PRO n 
1 10  SER n 
1 11  GLY n 
1 12  LYS n 
1 13  VAL n 
1 14  GLU n 
1 15  GLY n 
1 16  CYS n 
1 17  MET n 
1 18  VAL n 
1 19  GLN n 
1 20  VAL n 
1 21  ILE n 
1 22  CYS n 
1 23  GLY n 
1 24  THR n 
1 25  THR n 
1 26  THR n 
1 27  LEU n 
1 28  ASN n 
1 29  GLY n 
1 30  LEU n 
1 31  TRP n 
1 32  LEU n 
1 33  ASP n 
1 34  ASP n 
1 35  VAL n 
1 36  VAL n 
1 37  TYR n 
1 38  CYS n 
1 39  PRO n 
1 40  ARG n 
1 41  HIS n 
1 42  VAL n 
1 43  ILE n 
1 44  CYS n 
1 45  THR n 
1 46  SER n 
1 47  GLU n 
1 48  ASP n 
1 49  MET n 
1 50  LEU n 
1 51  ASN n 
1 52  PRO n 
1 53  ASN n 
1 54  TYR n 
1 55  GLU n 
1 56  ASP n 
1 57  LEU n 
1 58  LEU n 
1 59  ILE n 
1 60  ARG n 
1 61  LYS n 
1 62  SER n 
1 63  ASN n 
1 64  HIS n 
1 65  ASN n 
1 66  PHE n 
1 67  LEU n 
1 68  VAL n 
1 69  GLN n 
1 70  ALA n 
1 71  GLY n 
1 72  ASN n 
1 73  VAL n 
1 74  GLN n 
1 75  LEU n 
1 76  ARG n 
1 77  VAL n 
1 78  ILE n 
1 79  GLY n 
1 80  HIS n 
1 81  SER n 
1 82  MET n 
1 83  GLN n 
1 84  ASN n 
1 85  CYS n 
1 86  VAL n 
1 87  LEU n 
1 88  LYS n 
1 89  LEU n 
1 90  LYS n 
1 91  VAL n 
1 92  ASP n 
1 93  THR n 
1 94  ALA n 
1 95  ASN n 
1 96  PRO n 
1 97  LYS n 
1 98  THR n 
1 99  PRO n 
1 100 LYS n 
1 101 TYR n 
1 102 LYS n 
1 103 PHE n 
1 104 VAL n 
1 105 ARG n 
1 106 ILE n 
1 107 GLN n 
1 108 PRO n 
1 109 GLY n 
1 110 GLN n 
1 111 THR n 
1 112 PHE n 
1 113 SER n 
1 114 VAL n 
1 115 LEU n 
1 116 ALA n 
1 117 CYS n 
1 118 TYR n 
1 119 ASN n 
1 120 GLY n 
1 121 SER n 
1 122 PRO n 
1 123 SER n 
1 124 GLY n 
1 125 VAL n 
1 126 TYR n 
1 127 GLN n 
1 128 CYS n 
1 129 ALA n 
1 130 MET n 
1 131 ARG n 
1 132 PRO n 
1 133 ASN n 
1 134 PHE n 
1 135 THR n 
1 136 ILE n 
1 137 LYS n 
1 138 GLY n 
1 139 SER n 
1 140 PHE n 
1 141 LEU n 
1 142 ASN n 
1 143 GLY n 
1 144 SER n 
1 145 CYS n 
1 146 GLY n 
1 147 SER n 
1 148 VAL n 
1 149 GLY n 
1 150 PHE n 
1 151 ASN n 
1 152 ILE n 
1 153 ASP n 
1 154 TYR n 
1 155 ASP n 
1 156 CYS n 
1 157 VAL n 
1 158 SER n 
1 159 PHE n 
1 160 CYS n 
1 161 TYR n 
1 162 MET n 
1 163 HIS n 
1 164 HIS n 
1 165 MET n 
1 166 GLU n 
1 167 LEU n 
1 168 PRO n 
1 169 THR n 
1 170 GLY n 
1 171 VAL n 
1 172 HIS n 
1 173 ALA n 
1 174 GLY n 
1 175 THR n 
1 176 ASP n 
1 177 LEU n 
1 178 GLU n 
1 179 GLY n 
1 180 ASN n 
1 181 PHE n 
1 182 TYR n 
1 183 GLY n 
1 184 PRO n 
1 185 PHE n 
1 186 VAL n 
1 187 ASP n 
1 188 ARG n 
1 189 GLN n 
1 190 THR n 
1 191 ALA n 
1 192 GLN n 
1 193 ALA n 
1 194 ALA n 
1 195 GLY n 
1 196 THR n 
1 197 ASP n 
1 198 THR n 
1 199 THR n 
1 200 ILE n 
1 201 THR n 
1 202 VAL n 
1 203 ASN n 
1 204 VAL n 
1 205 LEU n 
1 206 ALA n 
1 207 TRP n 
1 208 LEU n 
1 209 TYR n 
1 210 ALA n 
1 211 ALA n 
1 212 VAL n 
1 213 ILE n 
1 214 ASN n 
1 215 GLY n 
1 216 ASP n 
1 217 ARG n 
1 218 TRP n 
1 219 PHE n 
1 220 LEU n 
1 221 ASN n 
1 222 ARG n 
1 223 PHE n 
1 224 THR n 
1 225 THR n 
1 226 THR n 
1 227 LEU n 
1 228 ASN n 
1 229 ASP n 
1 230 PHE n 
1 231 ASN n 
1 232 LEU n 
1 233 VAL n 
1 234 ALA n 
1 235 MET n 
1 236 LYS n 
1 237 TYR n 
1 238 ASN n 
1 239 TYR n 
1 240 GLU n 
1 241 PRO n 
1 242 LEU n 
1 243 THR n 
1 244 GLN n 
1 245 ASP n 
1 246 HIS n 
1 247 VAL n 
1 248 ASP n 
1 249 ILE n 
1 250 LEU n 
1 251 GLY n 
1 252 PRO n 
1 253 LEU n 
1 254 SER n 
1 255 ALA n 
1 256 GLN n 
1 257 THR n 
1 258 GLY n 
1 259 ILE n 
1 260 ALA n 
1 261 VAL n 
1 262 LEU n 
1 263 ASP n 
1 264 MET n 
1 265 CYS n 
1 266 ALA n 
1 267 SER n 
1 268 LEU n 
1 269 LYS n 
1 270 GLU n 
1 271 LEU n 
1 272 LEU n 
1 273 GLN n 
1 274 ASN n 
1 275 GLY n 
1 276 MET n 
1 277 ASN n 
1 278 GLY n 
1 279 ARG n 
1 280 THR n 
1 281 ILE n 
1 282 LEU n 
1 283 GLY n 
1 284 SER n 
1 285 ALA n 
1 286 LEU n 
1 287 LEU n 
1 288 GLU n 
1 289 ASP n 
1 290 GLU n 
1 291 PHE n 
1 292 THR n 
1 293 PRO n 
1 294 PHE n 
1 295 ASP n 
1 296 VAL n 
1 297 VAL n 
1 298 ARG n 
1 299 GLN n 
1 300 CYS n 
1 301 SER n 
1 302 GLY n 
1 303 VAL n 
1 304 THR n 
1 305 PHE n 
1 306 GLN n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   306 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Severe acute respiratory syndrome coronavirus 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     2697049 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2'          89.093  
ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1'      175.209 
ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'         132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'          133.103 
CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'        121.158 
GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'        146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'          147.129 
GLY 'peptide linking'   y GLYCINE ? 'C2 H5 N O2'          75.067  
HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1'      156.162 
HOH non-polymer         . WATER ? 'H2 O'                18.015  
ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'         131.173 
LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'         131.173 
LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1'      147.195 
MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'       149.211 
PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'         165.189 
PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2'          115.130 
SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3'          105.093 
THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3'          119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'       204.225 
TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'         181.189 
VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2'         117.146 
XEK non-polymer         . 
;(5P)-5-[(1P,3M,3'P)-3-{3-chloro-5-[(2-chlorophenyl)methoxy]-4-fluorophenyl}-2-oxo-2H-[1,3'-bipyridin]-5-yl]-1-methylpyrimidine-2,4(1H,3H)-dione
;
? 'C28 H19 Cl2 F N4 O4' 565.379 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   1   1   SER SER A . n 
A 1 2   GLY 2   2   2   GLY GLY A . n 
A 1 3   PHE 3   3   3   PHE PHE A . n 
A 1 4   ARG 4   4   4   ARG ARG A . n 
A 1 5   LYS 5   5   5   LYS LYS A . n 
A 1 6   MET 6   6   6   MET MET A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   PHE 8   8   8   PHE PHE A . n 
A 1 9   PRO 9   9   9   PRO PRO A . n 
A 1 10  SER 10  10  10  SER SER A . n 
A 1 11  GLY 11  11  11  GLY GLY A . n 
A 1 12  LYS 12  12  12  LYS LYS A . n 
A 1 13  VAL 13  13  13  VAL VAL A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  GLY 15  15  15  GLY GLY A . n 
A 1 16  CYS 16  16  16  CYS CYS A . n 
A 1 17  MET 17  17  17  MET MET A . n 
A 1 18  VAL 18  18  18  VAL VAL A . n 
A 1 19  GLN 19  19  19  GLN GLN A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  ILE 21  21  21  ILE ILE A . n 
A 1 22  CYS 22  22  22  CYS CYS A . n 
A 1 23  GLY 23  23  23  GLY GLY A . n 
A 1 24  THR 24  24  24  THR THR A . n 
A 1 25  THR 25  25  25  THR THR A . n 
A 1 26  THR 26  26  26  THR THR A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  ASN 28  28  28  ASN ASN A . n 
A 1 29  GLY 29  29  29  GLY GLY A . n 
A 1 30  LEU 30  30  30  LEU LEU A . n 
A 1 31  TRP 31  31  31  TRP TRP A . n 
A 1 32  LEU 32  32  32  LEU LEU A . n 
A 1 33  ASP 33  33  33  ASP ASP A . n 
A 1 34  ASP 34  34  34  ASP ASP A . n 
A 1 35  VAL 35  35  35  VAL VAL A . n 
A 1 36  VAL 36  36  36  VAL VAL A . n 
A 1 37  TYR 37  37  37  TYR TYR A . n 
A 1 38  CYS 38  38  38  CYS CYS A . n 
A 1 39  PRO 39  39  39  PRO PRO A . n 
A 1 40  ARG 40  40  40  ARG ARG A . n 
A 1 41  HIS 41  41  41  HIS HIS A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  ILE 43  43  43  ILE ILE A . n 
A 1 44  CYS 44  44  44  CYS CYS A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  SER 46  46  46  SER SER A . n 
A 1 47  GLU 47  47  47  GLU GLU A . n 
A 1 48  ASP 48  48  48  ASP ASP A . n 
A 1 49  MET 49  49  49  MET MET A . n 
A 1 50  LEU 50  50  50  LEU LEU A . n 
A 1 51  ASN 51  51  51  ASN ASN A . n 
A 1 52  PRO 52  52  52  PRO PRO A . n 
A 1 53  ASN 53  53  53  ASN ASN A . n 
A 1 54  TYR 54  54  54  TYR TYR A . n 
A 1 55  GLU 55  55  55  GLU GLU A . n 
A 1 56  ASP 56  56  56  ASP ASP A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  ILE 59  59  59  ILE ILE A . n 
A 1 60  ARG 60  60  60  ARG ARG A . n 
A 1 61  LYS 61  61  61  LYS LYS A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  ASN 63  63  63  ASN ASN A . n 
A 1 64  HIS 64  64  64  HIS HIS A . n 
A 1 65  ASN 65  65  65  ASN ASN A . n 
A 1 66  PHE 66  66  66  PHE PHE A . n 
A 1 67  LEU 67  67  67  LEU LEU A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  GLN 69  69  69  GLN GLN A . n 
A 1 70  ALA 70  70  70  ALA ALA A . n 
A 1 71  GLY 71  71  71  GLY GLY A . n 
A 1 72  ASN 72  72  72  ASN ASN A . n 
A 1 73  VAL 73  73  73  VAL VAL A . n 
A 1 74  GLN 74  74  74  GLN GLN A . n 
A 1 75  LEU 75  75  75  LEU LEU A . n 
A 1 76  ARG 76  76  76  ARG ARG A . n 
A 1 77  VAL 77  77  77  VAL VAL A . n 
A 1 78  ILE 78  78  78  ILE ILE A . n 
A 1 79  GLY 79  79  79  GLY GLY A . n 
A 1 80  HIS 80  80  80  HIS HIS A . n 
A 1 81  SER 81  81  81  SER SER A . n 
A 1 82  MET 82  82  82  MET MET A . n 
A 1 83  GLN 83  83  83  GLN GLN A . n 
A 1 84  ASN 84  84  84  ASN ASN A . n 
A 1 85  CYS 85  85  85  CYS CYS A . n 
A 1 86  VAL 86  86  86  VAL VAL A . n 
A 1 87  LEU 87  87  87  LEU LEU A . n 
A 1 88  LYS 88  88  88  LYS LYS A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  LYS 90  90  90  LYS LYS A . n 
A 1 91  VAL 91  91  91  VAL VAL A . n 
A 1 92  ASP 92  92  92  ASP ASP A . n 
A 1 93  THR 93  93  93  THR THR A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  PRO 96  96  96  PRO PRO A . n 
A 1 97  LYS 97  97  97  LYS LYS A . n 
A 1 98  THR 98  98  98  THR THR A . n 
A 1 99  PRO 99  99  99  PRO PRO A . n 
A 1 100 LYS 100 100 100 LYS LYS A . n 
A 1 101 TYR 101 101 101 TYR TYR A . n 
A 1 102 LYS 102 102 102 LYS LYS A . n 
A 1 103 PHE 103 103 103 PHE PHE A . n 
A 1 104 VAL 104 104 104 VAL VAL A . n 
A 1 105 ARG 105 105 105 ARG ARG A . n 
A 1 106 ILE 106 106 106 ILE ILE A . n 
A 1 107 GLN 107 107 107 GLN GLN A . n 
A 1 108 PRO 108 108 108 PRO PRO A . n 
A 1 109 GLY 109 109 109 GLY GLY A . n 
A 1 110 GLN 110 110 110 GLN GLN A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 PHE 112 112 112 PHE PHE A . n 
A 1 113 SER 113 113 113 SER SER A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 LEU 115 115 115 LEU LEU A . n 
A 1 116 ALA 116 116 116 ALA ALA A . n 
A 1 117 CYS 117 117 117 CYS CYS A . n 
A 1 118 TYR 118 118 118 TYR TYR A . n 
A 1 119 ASN 119 119 119 ASN ASN A . n 
A 1 120 GLY 120 120 120 GLY GLY A . n 
A 1 121 SER 121 121 121 SER SER A . n 
A 1 122 PRO 122 122 122 PRO PRO A . n 
A 1 123 SER 123 123 123 SER SER A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 TYR 126 126 126 TYR TYR A . n 
A 1 127 GLN 127 127 127 GLN GLN A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 ALA 129 129 129 ALA ALA A . n 
A 1 130 MET 130 130 130 MET MET A . n 
A 1 131 ARG 131 131 131 ARG ARG A . n 
A 1 132 PRO 132 132 132 PRO PRO A . n 
A 1 133 ASN 133 133 133 ASN ASN A . n 
A 1 134 PHE 134 134 134 PHE PHE A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 LYS 137 137 137 LYS LYS A . n 
A 1 138 GLY 138 138 138 GLY GLY A . n 
A 1 139 SER 139 139 139 SER SER A . n 
A 1 140 PHE 140 140 140 PHE PHE A . n 
A 1 141 LEU 141 141 141 LEU LEU A . n 
A 1 142 ASN 142 142 142 ASN ASN A . n 
A 1 143 GLY 143 143 143 GLY GLY A . n 
A 1 144 SER 144 144 144 SER SER A . n 
A 1 145 CYS 145 145 145 CYS CYS A . n 
A 1 146 GLY 146 146 146 GLY GLY A . n 
A 1 147 SER 147 147 147 SER SER A . n 
A 1 148 VAL 148 148 148 VAL VAL A . n 
A 1 149 GLY 149 149 149 GLY GLY A . n 
A 1 150 PHE 150 150 150 PHE PHE A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 ILE 152 152 152 ILE ILE A . n 
A 1 153 ASP 153 153 153 ASP ASP A . n 
A 1 154 TYR 154 154 154 TYR TYR A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 CYS 156 156 156 CYS CYS A . n 
A 1 157 VAL 157 157 157 VAL VAL A . n 
A 1 158 SER 158 158 158 SER SER A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 CYS 160 160 160 CYS CYS A . n 
A 1 161 TYR 161 161 161 TYR TYR A . n 
A 1 162 MET 162 162 162 MET MET A . n 
A 1 163 HIS 163 163 163 HIS HIS A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 MET 165 165 165 MET MET A . n 
A 1 166 GLU 166 166 166 GLU GLU A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 PRO 168 168 168 PRO PRO A . n 
A 1 169 THR 169 169 169 THR THR A . n 
A 1 170 GLY 170 170 170 GLY GLY A . n 
A 1 171 VAL 171 171 171 VAL VAL A . n 
A 1 172 HIS 172 172 172 HIS HIS A . n 
A 1 173 ALA 173 173 173 ALA ALA A . n 
A 1 174 GLY 174 174 174 GLY GLY A . n 
A 1 175 THR 175 175 175 THR THR A . n 
A 1 176 ASP 176 176 176 ASP ASP A . n 
A 1 177 LEU 177 177 177 LEU LEU A . n 
A 1 178 GLU 178 178 178 GLU GLU A . n 
A 1 179 GLY 179 179 179 GLY GLY A . n 
A 1 180 ASN 180 180 180 ASN ASN A . n 
A 1 181 PHE 181 181 181 PHE PHE A . n 
A 1 182 TYR 182 182 182 TYR TYR A . n 
A 1 183 GLY 183 183 183 GLY GLY A . n 
A 1 184 PRO 184 184 184 PRO PRO A . n 
A 1 185 PHE 185 185 185 PHE PHE A . n 
A 1 186 VAL 186 186 186 VAL VAL A . n 
A 1 187 ASP 187 187 187 ASP ASP A . n 
A 1 188 ARG 188 188 188 ARG ARG A . n 
A 1 189 GLN 189 189 189 GLN GLN A . n 
A 1 190 THR 190 190 190 THR THR A . n 
A 1 191 ALA 191 191 191 ALA ALA A . n 
A 1 192 GLN 192 192 192 GLN GLN A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ALA 194 194 194 ALA ALA A . n 
A 1 195 GLY 195 195 195 GLY GLY A . n 
A 1 196 THR 196 196 196 THR THR A . n 
A 1 197 ASP 197 197 197 ASP ASP A . n 
A 1 198 THR 198 198 198 THR THR A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 ILE 200 200 200 ILE ILE A . n 
A 1 201 THR 201 201 201 THR THR A . n 
A 1 202 VAL 202 202 202 VAL VAL A . n 
A 1 203 ASN 203 203 203 ASN ASN A . n 
A 1 204 VAL 204 204 204 VAL VAL A . n 
A 1 205 LEU 205 205 205 LEU LEU A . n 
A 1 206 ALA 206 206 206 ALA ALA A . n 
A 1 207 TRP 207 207 207 TRP TRP A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 TYR 209 209 209 TYR TYR A . n 
A 1 210 ALA 210 210 210 ALA ALA A . n 
A 1 211 ALA 211 211 211 ALA ALA A . n 
A 1 212 VAL 212 212 212 VAL VAL A . n 
A 1 213 ILE 213 213 213 ILE ILE A . n 
A 1 214 ASN 214 214 214 ASN ASN A . n 
A 1 215 GLY 215 215 215 GLY GLY A . n 
A 1 216 ASP 216 216 216 ASP ASP A . n 
A 1 217 ARG 217 217 217 ARG ARG A . n 
A 1 218 TRP 218 218 218 TRP TRP A . n 
A 1 219 PHE 219 219 219 PHE PHE A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 ASN 221 221 221 ASN ASN A . n 
A 1 222 ARG 222 222 222 ARG ARG A . n 
A 1 223 PHE 223 223 223 PHE PHE A . n 
A 1 224 THR 224 224 224 THR THR A . n 
A 1 225 THR 225 225 225 THR THR A . n 
A 1 226 THR 226 226 226 THR THR A . n 
A 1 227 LEU 227 227 227 LEU LEU A . n 
A 1 228 ASN 228 228 228 ASN ASN A . n 
A 1 229 ASP 229 229 229 ASP ASP A . n 
A 1 230 PHE 230 230 230 PHE PHE A . n 
A 1 231 ASN 231 231 231 ASN ASN A . n 
A 1 232 LEU 232 232 232 LEU LEU A . n 
A 1 233 VAL 233 233 233 VAL VAL A . n 
A 1 234 ALA 234 234 234 ALA ALA A . n 
A 1 235 MET 235 235 235 MET MET A . n 
A 1 236 LYS 236 236 236 LYS LYS A . n 
A 1 237 TYR 237 237 237 TYR TYR A . n 
A 1 238 ASN 238 238 238 ASN ASN A . n 
A 1 239 TYR 239 239 239 TYR TYR A . n 
A 1 240 GLU 240 240 240 GLU GLU A . n 
A 1 241 PRO 241 241 241 PRO PRO A . n 
A 1 242 LEU 242 242 242 LEU LEU A . n 
A 1 243 THR 243 243 243 THR THR A . n 
A 1 244 GLN 244 244 244 GLN GLN A . n 
A 1 245 ASP 245 245 245 ASP ASP A . n 
A 1 246 HIS 246 246 246 HIS HIS A . n 
A 1 247 VAL 247 247 247 VAL VAL A . n 
A 1 248 ASP 248 248 248 ASP ASP A . n 
A 1 249 ILE 249 249 249 ILE ILE A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 PRO 252 252 252 PRO PRO A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 SER 254 254 254 SER SER A . n 
A 1 255 ALA 255 255 255 ALA ALA A . n 
A 1 256 GLN 256 256 256 GLN GLN A . n 
A 1 257 THR 257 257 257 THR THR A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 ILE 259 259 259 ILE ILE A . n 
A 1 260 ALA 260 260 260 ALA ALA A . n 
A 1 261 VAL 261 261 261 VAL VAL A . n 
A 1 262 LEU 262 262 262 LEU LEU A . n 
A 1 263 ASP 263 263 263 ASP ASP A . n 
A 1 264 MET 264 264 264 MET MET A . n 
A 1 265 CYS 265 265 265 CYS CYS A . n 
A 1 266 ALA 266 266 266 ALA ALA A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 LEU 268 268 268 LEU LEU A . n 
A 1 269 LYS 269 269 269 LYS LYS A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 LEU 271 271 271 LEU LEU A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 GLN 273 273 273 GLN GLN A . n 
A 1 274 ASN 274 274 274 ASN ASN A . n 
A 1 275 GLY 275 275 275 GLY GLY A . n 
A 1 276 MET 276 276 276 MET MET A . n 
A 1 277 ASN 277 277 277 ASN ASN A . n 
A 1 278 GLY 278 278 278 GLY GLY A . n 
A 1 279 ARG 279 279 279 ARG ARG A . n 
A 1 280 THR 280 280 280 THR THR A . n 
A 1 281 ILE 281 281 281 ILE ILE A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 GLY 283 283 283 GLY GLY A . n 
A 1 284 SER 284 284 284 SER SER A . n 
A 1 285 ALA 285 285 285 ALA ALA A . n 
A 1 286 LEU 286 286 286 LEU LEU A . n 
A 1 287 LEU 287 287 287 LEU LEU A . n 
A 1 288 GLU 288 288 288 GLU GLU A . n 
A 1 289 ASP 289 289 289 ASP ASP A . n 
A 1 290 GLU 290 290 290 GLU GLU A . n 
A 1 291 PHE 291 291 291 PHE PHE A . n 
A 1 292 THR 292 292 292 THR THR A . n 
A 1 293 PRO 293 293 293 PRO PRO A . n 
A 1 294 PHE 294 294 294 PHE PHE A . n 
A 1 295 ASP 295 295 295 ASP ASP A . n 
A 1 296 VAL 296 296 296 VAL VAL A . n 
A 1 297 VAL 297 297 297 VAL VAL A . n 
A 1 298 ARG 298 298 298 ARG ARG A . n 
A 1 299 GLN 299 299 299 GLN GLN A . n 
A 1 300 CYS 300 300 300 CYS CYS A . n 
A 1 301 SER 301 301 301 SER SER A . n 
A 1 302 GLY 302 302 ?   ?   ?   A . n 
A 1 303 VAL 303 303 ?   ?   ?   A . n 
A 1 304 THR 304 304 ?   ?   ?   A . n 
A 1 305 PHE 305 305 ?   ?   ?   A . n 
A 1 306 GLN 306 306 ?   ?   ?   A . n 
B 1 1   SER 1   1   1   SER SER B . n 
B 1 2   GLY 2   2   2   GLY GLY B . n 
B 1 3   PHE 3   3   3   PHE PHE B . n 
B 1 4   ARG 4   4   4   ARG ARG B . n 
B 1 5   LYS 5   5   5   LYS LYS B . n 
B 1 6   MET 6   6   6   MET MET B . n 
B 1 7   ALA 7   7   7   ALA ALA B . n 
B 1 8   PHE 8   8   8   PHE PHE B . n 
B 1 9   PRO 9   9   9   PRO PRO B . n 
B 1 10  SER 10  10  10  SER SER B . n 
B 1 11  GLY 11  11  11  GLY GLY B . n 
B 1 12  LYS 12  12  12  LYS LYS B . n 
B 1 13  VAL 13  13  13  VAL VAL B . n 
B 1 14  GLU 14  14  14  GLU GLU B . n 
B 1 15  GLY 15  15  15  GLY GLY B . n 
B 1 16  CYS 16  16  16  CYS CYS B . n 
B 1 17  MET 17  17  17  MET MET B . n 
B 1 18  VAL 18  18  18  VAL VAL B . n 
B 1 19  GLN 19  19  19  GLN GLN B . n 
B 1 20  VAL 20  20  20  VAL VAL B . n 
B 1 21  ILE 21  21  21  ILE ILE B . n 
B 1 22  CYS 22  22  22  CYS CYS B . n 
B 1 23  GLY 23  23  23  GLY GLY B . n 
B 1 24  THR 24  24  24  THR THR B . n 
B 1 25  THR 25  25  25  THR THR B . n 
B 1 26  THR 26  26  26  THR THR B . n 
B 1 27  LEU 27  27  27  LEU LEU B . n 
B 1 28  ASN 28  28  28  ASN ASN B . n 
B 1 29  GLY 29  29  29  GLY GLY B . n 
B 1 30  LEU 30  30  30  LEU LEU B . n 
B 1 31  TRP 31  31  31  TRP TRP B . n 
B 1 32  LEU 32  32  32  LEU LEU B . n 
B 1 33  ASP 33  33  33  ASP ASP B . n 
B 1 34  ASP 34  34  34  ASP ASP B . n 
B 1 35  VAL 35  35  35  VAL VAL B . n 
B 1 36  VAL 36  36  36  VAL VAL B . n 
B 1 37  TYR 37  37  37  TYR TYR B . n 
B 1 38  CYS 38  38  38  CYS CYS B . n 
B 1 39  PRO 39  39  39  PRO PRO B . n 
B 1 40  ARG 40  40  40  ARG ARG B . n 
B 1 41  HIS 41  41  41  HIS HIS B . n 
B 1 42  VAL 42  42  42  VAL VAL B . n 
B 1 43  ILE 43  43  43  ILE ILE B . n 
B 1 44  CYS 44  44  44  CYS CYS B . n 
B 1 45  THR 45  45  45  THR THR B . n 
B 1 46  SER 46  46  46  SER SER B . n 
B 1 47  GLU 47  47  47  GLU GLU B . n 
B 1 48  ASP 48  48  48  ASP ASP B . n 
B 1 49  MET 49  49  49  MET MET B . n 
B 1 50  LEU 50  50  50  LEU LEU B . n 
B 1 51  ASN 51  51  51  ASN ASN B . n 
B 1 52  PRO 52  52  52  PRO PRO B . n 
B 1 53  ASN 53  53  53  ASN ASN B . n 
B 1 54  TYR 54  54  54  TYR TYR B . n 
B 1 55  GLU 55  55  55  GLU GLU B . n 
B 1 56  ASP 56  56  56  ASP ASP B . n 
B 1 57  LEU 57  57  57  LEU LEU B . n 
B 1 58  LEU 58  58  58  LEU LEU B . n 
B 1 59  ILE 59  59  59  ILE ILE B . n 
B 1 60  ARG 60  60  60  ARG ARG B . n 
B 1 61  LYS 61  61  61  LYS LYS B . n 
B 1 62  SER 62  62  62  SER SER B . n 
B 1 63  ASN 63  63  63  ASN ASN B . n 
B 1 64  HIS 64  64  64  HIS HIS B . n 
B 1 65  ASN 65  65  65  ASN ASN B . n 
B 1 66  PHE 66  66  66  PHE PHE B . n 
B 1 67  LEU 67  67  67  LEU LEU B . n 
B 1 68  VAL 68  68  68  VAL VAL B . n 
B 1 69  GLN 69  69  69  GLN GLN B . n 
B 1 70  ALA 70  70  70  ALA ALA B . n 
B 1 71  GLY 71  71  71  GLY GLY B . n 
B 1 72  ASN 72  72  72  ASN ASN B . n 
B 1 73  VAL 73  73  73  VAL VAL B . n 
B 1 74  GLN 74  74  74  GLN GLN B . n 
B 1 75  LEU 75  75  75  LEU LEU B . n 
B 1 76  ARG 76  76  76  ARG ARG B . n 
B 1 77  VAL 77  77  77  VAL VAL B . n 
B 1 78  ILE 78  78  78  ILE ILE B . n 
B 1 79  GLY 79  79  79  GLY GLY B . n 
B 1 80  HIS 80  80  80  HIS HIS B . n 
B 1 81  SER 81  81  81  SER SER B . n 
B 1 82  MET 82  82  82  MET MET B . n 
B 1 83  GLN 83  83  83  GLN GLN B . n 
B 1 84  ASN 84  84  84  ASN ASN B . n 
B 1 85  CYS 85  85  85  CYS CYS B . n 
B 1 86  VAL 86  86  86  VAL VAL B . n 
B 1 87  LEU 87  87  87  LEU LEU B . n 
B 1 88  LYS 88  88  88  LYS LYS B . n 
B 1 89  LEU 89  89  89  LEU LEU B . n 
B 1 90  LYS 90  90  90  LYS LYS B . n 
B 1 91  VAL 91  91  91  VAL VAL B . n 
B 1 92  ASP 92  92  92  ASP ASP B . n 
B 1 93  THR 93  93  93  THR THR B . n 
B 1 94  ALA 94  94  94  ALA ALA B . n 
B 1 95  ASN 95  95  95  ASN ASN B . n 
B 1 96  PRO 96  96  96  PRO PRO B . n 
B 1 97  LYS 97  97  97  LYS LYS B . n 
B 1 98  THR 98  98  98  THR THR B . n 
B 1 99  PRO 99  99  99  PRO PRO B . n 
B 1 100 LYS 100 100 100 LYS LYS B . n 
B 1 101 TYR 101 101 101 TYR TYR B . n 
B 1 102 LYS 102 102 102 LYS LYS B . n 
B 1 103 PHE 103 103 103 PHE PHE B . n 
B 1 104 VAL 104 104 104 VAL VAL B . n 
B 1 105 ARG 105 105 105 ARG ARG B . n 
B 1 106 ILE 106 106 106 ILE ILE B . n 
B 1 107 GLN 107 107 107 GLN GLN B . n 
B 1 108 PRO 108 108 108 PRO PRO B . n 
B 1 109 GLY 109 109 109 GLY GLY B . n 
B 1 110 GLN 110 110 110 GLN GLN B . n 
B 1 111 THR 111 111 111 THR THR B . n 
B 1 112 PHE 112 112 112 PHE PHE B . n 
B 1 113 SER 113 113 113 SER SER B . n 
B 1 114 VAL 114 114 114 VAL VAL B . n 
B 1 115 LEU 115 115 115 LEU LEU B . n 
B 1 116 ALA 116 116 116 ALA ALA B . n 
B 1 117 CYS 117 117 117 CYS CYS B . n 
B 1 118 TYR 118 118 118 TYR TYR B . n 
B 1 119 ASN 119 119 119 ASN ASN B . n 
B 1 120 GLY 120 120 120 GLY GLY B . n 
B 1 121 SER 121 121 121 SER SER B . n 
B 1 122 PRO 122 122 122 PRO PRO B . n 
B 1 123 SER 123 123 123 SER SER B . n 
B 1 124 GLY 124 124 124 GLY GLY B . n 
B 1 125 VAL 125 125 125 VAL VAL B . n 
B 1 126 TYR 126 126 126 TYR TYR B . n 
B 1 127 GLN 127 127 127 GLN GLN B . n 
B 1 128 CYS 128 128 128 CYS CYS B . n 
B 1 129 ALA 129 129 129 ALA ALA B . n 
B 1 130 MET 130 130 130 MET MET B . n 
B 1 131 ARG 131 131 131 ARG ARG B . n 
B 1 132 PRO 132 132 132 PRO PRO B . n 
B 1 133 ASN 133 133 133 ASN ASN B . n 
B 1 134 PHE 134 134 134 PHE PHE B . n 
B 1 135 THR 135 135 135 THR THR B . n 
B 1 136 ILE 136 136 136 ILE ILE B . n 
B 1 137 LYS 137 137 137 LYS LYS B . n 
B 1 138 GLY 138 138 138 GLY GLY B . n 
B 1 139 SER 139 139 139 SER SER B . n 
B 1 140 PHE 140 140 140 PHE PHE B . n 
B 1 141 LEU 141 141 141 LEU LEU B . n 
B 1 142 ASN 142 142 142 ASN ASN B . n 
B 1 143 GLY 143 143 143 GLY GLY B . n 
B 1 144 SER 144 144 144 SER SER B . n 
B 1 145 CYS 145 145 145 CYS CYS B . n 
B 1 146 GLY 146 146 146 GLY GLY B . n 
B 1 147 SER 147 147 147 SER SER B . n 
B 1 148 VAL 148 148 148 VAL VAL B . n 
B 1 149 GLY 149 149 149 GLY GLY B . n 
B 1 150 PHE 150 150 150 PHE PHE B . n 
B 1 151 ASN 151 151 151 ASN ASN B . n 
B 1 152 ILE 152 152 152 ILE ILE B . n 
B 1 153 ASP 153 153 153 ASP ASP B . n 
B 1 154 TYR 154 154 154 TYR TYR B . n 
B 1 155 ASP 155 155 155 ASP ASP B . n 
B 1 156 CYS 156 156 156 CYS CYS B . n 
B 1 157 VAL 157 157 157 VAL VAL B . n 
B 1 158 SER 158 158 158 SER SER B . n 
B 1 159 PHE 159 159 159 PHE PHE B . n 
B 1 160 CYS 160 160 160 CYS CYS B . n 
B 1 161 TYR 161 161 161 TYR TYR B . n 
B 1 162 MET 162 162 162 MET MET B . n 
B 1 163 HIS 163 163 163 HIS HIS B . n 
B 1 164 HIS 164 164 164 HIS HIS B . n 
B 1 165 MET 165 165 165 MET MET B . n 
B 1 166 GLU 166 166 166 GLU GLU B . n 
B 1 167 LEU 167 167 167 LEU LEU B . n 
B 1 168 PRO 168 168 168 PRO PRO B . n 
B 1 169 THR 169 169 169 THR THR B . n 
B 1 170 GLY 170 170 170 GLY GLY B . n 
B 1 171 VAL 171 171 171 VAL VAL B . n 
B 1 172 HIS 172 172 172 HIS HIS B . n 
B 1 173 ALA 173 173 173 ALA ALA B . n 
B 1 174 GLY 174 174 174 GLY GLY B . n 
B 1 175 THR 175 175 175 THR THR B . n 
B 1 176 ASP 176 176 176 ASP ASP B . n 
B 1 177 LEU 177 177 177 LEU LEU B . n 
B 1 178 GLU 178 178 178 GLU GLU B . n 
B 1 179 GLY 179 179 179 GLY GLY B . n 
B 1 180 ASN 180 180 180 ASN ASN B . n 
B 1 181 PHE 181 181 181 PHE PHE B . n 
B 1 182 TYR 182 182 182 TYR TYR B . n 
B 1 183 GLY 183 183 183 GLY GLY B . n 
B 1 184 PRO 184 184 184 PRO PRO B . n 
B 1 185 PHE 185 185 185 PHE PHE B . n 
B 1 186 VAL 186 186 186 VAL VAL B . n 
B 1 187 ASP 187 187 187 ASP ASP B . n 
B 1 188 ARG 188 188 188 ARG ARG B . n 
B 1 189 GLN 189 189 189 GLN GLN B . n 
B 1 190 THR 190 190 190 THR THR B . n 
B 1 191 ALA 191 191 191 ALA ALA B . n 
B 1 192 GLN 192 192 192 GLN GLN B . n 
B 1 193 ALA 193 193 193 ALA ALA B . n 
B 1 194 ALA 194 194 194 ALA ALA B . n 
B 1 195 GLY 195 195 195 GLY GLY B . n 
B 1 196 THR 196 196 196 THR THR B . n 
B 1 197 ASP 197 197 197 ASP ASP B . n 
B 1 198 THR 198 198 198 THR THR B . n 
B 1 199 THR 199 199 199 THR THR B . n 
B 1 200 ILE 200 200 200 ILE ILE B . n 
B 1 201 THR 201 201 201 THR THR B . n 
B 1 202 VAL 202 202 202 VAL VAL B . n 
B 1 203 ASN 203 203 203 ASN ASN B . n 
B 1 204 VAL 204 204 204 VAL VAL B . n 
B 1 205 LEU 205 205 205 LEU LEU B . n 
B 1 206 ALA 206 206 206 ALA ALA B . n 
B 1 207 TRP 207 207 207 TRP TRP B . n 
B 1 208 LEU 208 208 208 LEU LEU B . n 
B 1 209 TYR 209 209 209 TYR TYR B . n 
B 1 210 ALA 210 210 210 ALA ALA B . n 
B 1 211 ALA 211 211 211 ALA ALA B . n 
B 1 212 VAL 212 212 212 VAL VAL B . n 
B 1 213 ILE 213 213 213 ILE ILE B . n 
B 1 214 ASN 214 214 214 ASN ASN B . n 
B 1 215 GLY 215 215 215 GLY GLY B . n 
B 1 216 ASP 216 216 216 ASP ASP B . n 
B 1 217 ARG 217 217 217 ARG ARG B . n 
B 1 218 TRP 218 218 218 TRP TRP B . n 
B 1 219 PHE 219 219 219 PHE PHE B . n 
B 1 220 LEU 220 220 220 LEU LEU B . n 
B 1 221 ASN 221 221 221 ASN ASN B . n 
B 1 222 ARG 222 222 222 ARG ARG B . n 
B 1 223 PHE 223 223 223 PHE PHE B . n 
B 1 224 THR 224 224 224 THR THR B . n 
B 1 225 THR 225 225 225 THR THR B . n 
B 1 226 THR 226 226 226 THR THR B . n 
B 1 227 LEU 227 227 227 LEU LEU B . n 
B 1 228 ASN 228 228 228 ASN ASN B . n 
B 1 229 ASP 229 229 229 ASP ASP B . n 
B 1 230 PHE 230 230 230 PHE PHE B . n 
B 1 231 ASN 231 231 231 ASN ASN B . n 
B 1 232 LEU 232 232 232 LEU LEU B . n 
B 1 233 VAL 233 233 233 VAL VAL B . n 
B 1 234 ALA 234 234 234 ALA ALA B . n 
B 1 235 MET 235 235 235 MET MET B . n 
B 1 236 LYS 236 236 236 LYS LYS B . n 
B 1 237 TYR 237 237 237 TYR TYR B . n 
B 1 238 ASN 238 238 238 ASN ASN B . n 
B 1 239 TYR 239 239 239 TYR TYR B . n 
B 1 240 GLU 240 240 240 GLU GLU B . n 
B 1 241 PRO 241 241 241 PRO PRO B . n 
B 1 242 LEU 242 242 242 LEU LEU B . n 
B 1 243 THR 243 243 243 THR THR B . n 
B 1 244 GLN 244 244 244 GLN GLN B . n 
B 1 245 ASP 245 245 245 ASP ASP B . n 
B 1 246 HIS 246 246 246 HIS HIS B . n 
B 1 247 VAL 247 247 247 VAL VAL B . n 
B 1 248 ASP 248 248 248 ASP ASP B . n 
B 1 249 ILE 249 249 249 ILE ILE B . n 
B 1 250 LEU 250 250 250 LEU LEU B . n 
B 1 251 GLY 251 251 251 GLY GLY B . n 
B 1 252 PRO 252 252 252 PRO PRO B . n 
B 1 253 LEU 253 253 253 LEU LEU B . n 
B 1 254 SER 254 254 254 SER SER B . n 
B 1 255 ALA 255 255 255 ALA ALA B . n 
B 1 256 GLN 256 256 256 GLN GLN B . n 
B 1 257 THR 257 257 257 THR THR B . n 
B 1 258 GLY 258 258 258 GLY GLY B . n 
B 1 259 ILE 259 259 259 ILE ILE B . n 
B 1 260 ALA 260 260 260 ALA ALA B . n 
B 1 261 VAL 261 261 261 VAL VAL B . n 
B 1 262 LEU 262 262 262 LEU LEU B . n 
B 1 263 ASP 263 263 263 ASP ASP B . n 
B 1 264 MET 264 264 264 MET MET B . n 
B 1 265 CYS 265 265 265 CYS CYS B . n 
B 1 266 ALA 266 266 266 ALA ALA B . n 
B 1 267 SER 267 267 267 SER SER B . n 
B 1 268 LEU 268 268 268 LEU LEU B . n 
B 1 269 LYS 269 269 269 LYS LYS B . n 
B 1 270 GLU 270 270 270 GLU GLU B . n 
B 1 271 LEU 271 271 271 LEU LEU B . n 
B 1 272 LEU 272 272 272 LEU LEU B . n 
B 1 273 GLN 273 273 273 GLN GLN B . n 
B 1 274 ASN 274 274 274 ASN ASN B . n 
B 1 275 GLY 275 275 275 GLY GLY B . n 
B 1 276 MET 276 276 276 MET MET B . n 
B 1 277 ASN 277 277 277 ASN ASN B . n 
B 1 278 GLY 278 278 278 GLY GLY B . n 
B 1 279 ARG 279 279 279 ARG ARG B . n 
B 1 280 THR 280 280 280 THR THR B . n 
B 1 281 ILE 281 281 281 ILE ILE B . n 
B 1 282 LEU 282 282 282 LEU LEU B . n 
B 1 283 GLY 283 283 283 GLY GLY B . n 
B 1 284 SER 284 284 284 SER SER B . n 
B 1 285 ALA 285 285 285 ALA ALA B . n 
B 1 286 LEU 286 286 286 LEU LEU B . n 
B 1 287 LEU 287 287 287 LEU LEU B . n 
B 1 288 GLU 288 288 288 GLU GLU B . n 
B 1 289 ASP 289 289 289 ASP ASP B . n 
B 1 290 GLU 290 290 290 GLU GLU B . n 
B 1 291 PHE 291 291 291 PHE PHE B . n 
B 1 292 THR 292 292 292 THR THR B . n 
B 1 293 PRO 293 293 293 PRO PRO B . n 
B 1 294 PHE 294 294 294 PHE PHE B . n 
B 1 295 ASP 295 295 295 ASP ASP B . n 
B 1 296 VAL 296 296 296 VAL VAL B . n 
B 1 297 VAL 297 297 297 VAL VAL B . n 
B 1 298 ARG 298 298 298 ARG ARG B . n 
B 1 299 GLN 299 299 299 GLN GLN B . n 
B 1 300 CYS 300 300 300 CYS CYS B . n 
B 1 301 SER 301 301 301 SER SER B . n 
B 1 302 GLY 302 302 302 GLY GLY B . n 
B 1 303 VAL 303 303 303 VAL VAL B . n 
B 1 304 THR 304 304 ?   ?   ?   B . n 
B 1 305 PHE 305 305 ?   ?   ?   B . n 
B 1 306 GLN 306 306 ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        XEK 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   XEK 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 XEK 1  401 1   XEK M61 A . 
D 3 HOH 1  501 54  HOH HOH A . 
D 3 HOH 2  502 50  HOH HOH A . 
D 3 HOH 3  503 18  HOH HOH A . 
D 3 HOH 4  504 71  HOH HOH A . 
D 3 HOH 5  505 67  HOH HOH A . 
D 3 HOH 6  506 61  HOH HOH A . 
D 3 HOH 7  507 55  HOH HOH A . 
D 3 HOH 8  508 10  HOH HOH A . 
D 3 HOH 9  509 7   HOH HOH A . 
D 3 HOH 10 510 92  HOH HOH A . 
D 3 HOH 11 511 58  HOH HOH A . 
D 3 HOH 12 512 27  HOH HOH A . 
D 3 HOH 13 513 12  HOH HOH A . 
D 3 HOH 14 514 25  HOH HOH A . 
D 3 HOH 15 515 76  HOH HOH A . 
D 3 HOH 16 516 116 HOH HOH A . 
D 3 HOH 17 517 75  HOH HOH A . 
D 3 HOH 18 518 72  HOH HOH A . 
D 3 HOH 19 519 127 HOH HOH A . 
D 3 HOH 20 520 62  HOH HOH A . 
D 3 HOH 21 521 2   HOH HOH A . 
D 3 HOH 22 522 43  HOH HOH A . 
D 3 HOH 23 523 3   HOH HOH A . 
D 3 HOH 24 524 39  HOH HOH A . 
D 3 HOH 25 525 22  HOH HOH A . 
D 3 HOH 26 526 6   HOH HOH A . 
D 3 HOH 27 527 16  HOH HOH A . 
D 3 HOH 28 528 187 HOH HOH A . 
D 3 HOH 29 529 96  HOH HOH A . 
D 3 HOH 30 530 15  HOH HOH A . 
D 3 HOH 31 531 13  HOH HOH A . 
D 3 HOH 32 532 57  HOH HOH A . 
D 3 HOH 33 533 100 HOH HOH A . 
D 3 HOH 34 534 32  HOH HOH A . 
D 3 HOH 35 535 65  HOH HOH A . 
D 3 HOH 36 536 91  HOH HOH A . 
D 3 HOH 37 537 88  HOH HOH A . 
D 3 HOH 38 538 68  HOH HOH A . 
D 3 HOH 39 539 103 HOH HOH A . 
D 3 HOH 40 540 140 HOH HOH A . 
D 3 HOH 41 541 90  HOH HOH A . 
D 3 HOH 42 542 5   HOH HOH A . 
D 3 HOH 43 543 73  HOH HOH A . 
D 3 HOH 44 544 29  HOH HOH A . 
D 3 HOH 45 545 129 HOH HOH A . 
D 3 HOH 46 546 37  HOH HOH A . 
D 3 HOH 47 547 86  HOH HOH A . 
D 3 HOH 48 548 1   HOH HOH A . 
D 3 HOH 49 549 131 HOH HOH A . 
D 3 HOH 50 550 84  HOH HOH A . 
D 3 HOH 51 551 82  HOH HOH A . 
D 3 HOH 52 552 9   HOH HOH A . 
D 3 HOH 53 553 186 HOH HOH A . 
D 3 HOH 54 554 105 HOH HOH A . 
D 3 HOH 55 555 189 HOH HOH A . 
D 3 HOH 56 556 98  HOH HOH A . 
D 3 HOH 57 557 153 HOH HOH A . 
D 3 HOH 58 558 8   HOH HOH A . 
D 3 HOH 59 559 112 HOH HOH A . 
D 3 HOH 60 560 159 HOH HOH A . 
D 3 HOH 61 561 35  HOH HOH A . 
D 3 HOH 62 562 83  HOH HOH A . 
D 3 HOH 63 563 177 HOH HOH A . 
D 3 HOH 64 564 154 HOH HOH A . 
D 3 HOH 65 565 190 HOH HOH A . 
D 3 HOH 66 566 181 HOH HOH A . 
D 3 HOH 67 567 52  HOH HOH A . 
D 3 HOH 68 568 109 HOH HOH A . 
D 3 HOH 69 569 93  HOH HOH A . 
D 3 HOH 70 570 149 HOH HOH A . 
D 3 HOH 71 571 178 HOH HOH A . 
D 3 HOH 72 572 142 HOH HOH A . 
D 3 HOH 73 573 80  HOH HOH A . 
D 3 HOH 74 574 179 HOH HOH A . 
D 3 HOH 75 575 182 HOH HOH A . 
D 3 HOH 76 576 151 HOH HOH A . 
D 3 HOH 77 577 185 HOH HOH A . 
D 3 HOH 78 578 180 HOH HOH A . 
D 3 HOH 79 579 104 HOH HOH A . 
D 3 HOH 80 580 95  HOH HOH A . 
D 3 HOH 81 581 78  HOH HOH A . 
D 3 HOH 82 582 38  HOH HOH A . 
D 3 HOH 83 583 64  HOH HOH A . 
D 3 HOH 84 584 42  HOH HOH A . 
D 3 HOH 85 585 183 HOH HOH A . 
E 3 HOH 1  401 46  HOH HOH B . 
E 3 HOH 2  402 17  HOH HOH B . 
E 3 HOH 3  403 51  HOH HOH B . 
E 3 HOH 4  404 28  HOH HOH B . 
E 3 HOH 5  405 48  HOH HOH B . 
E 3 HOH 6  406 19  HOH HOH B . 
E 3 HOH 7  407 85  HOH HOH B . 
E 3 HOH 8  408 20  HOH HOH B . 
E 3 HOH 9  409 44  HOH HOH B . 
E 3 HOH 10 410 74  HOH HOH B . 
E 3 HOH 11 411 36  HOH HOH B . 
E 3 HOH 12 412 53  HOH HOH B . 
E 3 HOH 13 413 34  HOH HOH B . 
E 3 HOH 14 414 33  HOH HOH B . 
E 3 HOH 15 415 21  HOH HOH B . 
E 3 HOH 16 416 49  HOH HOH B . 
E 3 HOH 17 417 120 HOH HOH B . 
E 3 HOH 18 418 14  HOH HOH B . 
E 3 HOH 19 419 111 HOH HOH B . 
E 3 HOH 20 420 30  HOH HOH B . 
E 3 HOH 21 421 69  HOH HOH B . 
E 3 HOH 22 422 156 HOH HOH B . 
E 3 HOH 23 423 24  HOH HOH B . 
E 3 HOH 24 424 63  HOH HOH B . 
E 3 HOH 25 425 101 HOH HOH B . 
E 3 HOH 26 426 60  HOH HOH B . 
E 3 HOH 27 427 23  HOH HOH B . 
E 3 HOH 28 428 47  HOH HOH B . 
E 3 HOH 29 429 31  HOH HOH B . 
E 3 HOH 30 430 113 HOH HOH B . 
E 3 HOH 31 431 11  HOH HOH B . 
E 3 HOH 32 432 26  HOH HOH B . 
E 3 HOH 33 433 163 HOH HOH B . 
E 3 HOH 34 434 4   HOH HOH B . 
E 3 HOH 35 435 66  HOH HOH B . 
E 3 HOH 36 436 145 HOH HOH B . 
E 3 HOH 37 437 108 HOH HOH B . 
E 3 HOH 38 438 135 HOH HOH B . 
E 3 HOH 39 439 70  HOH HOH B . 
E 3 HOH 40 440 184 HOH HOH B . 
E 3 HOH 41 441 147 HOH HOH B . 
E 3 HOH 42 442 40  HOH HOH B . 
E 3 HOH 43 443 56  HOH HOH B . 
E 3 HOH 44 444 139 HOH HOH B . 
E 3 HOH 45 445 41  HOH HOH B . 
E 3 HOH 46 446 106 HOH HOH B . 
E 3 HOH 47 447 192 HOH HOH B . 
E 3 HOH 48 448 146 HOH HOH B . 
E 3 HOH 49 449 188 HOH HOH B . 
E 3 HOH 50 450 115 HOH HOH B . 
E 3 HOH 51 451 172 HOH HOH B . 
E 3 HOH 52 452 137 HOH HOH B . 
E 3 HOH 53 453 45  HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A GLU 47  ? CG  ? A GLU 47  CG  
2  1 Y 1 A GLU 47  ? CD  ? A GLU 47  CD  
3  1 Y 1 A GLU 47  ? OE1 ? A GLU 47  OE1 
4  1 Y 1 A GLU 47  ? OE2 ? A GLU 47  OE2 
5  1 Y 1 A LYS 100 ? CG  ? A LYS 100 CG  
6  1 Y 1 A LYS 100 ? CD  ? A LYS 100 CD  
7  1 Y 1 A LYS 100 ? CE  ? A LYS 100 CE  
8  1 Y 1 A LYS 100 ? NZ  ? A LYS 100 NZ  
9  1 Y 1 A ARG 222 ? CG  ? A ARG 222 CG  
10 1 Y 1 A ARG 222 ? CD  ? A ARG 222 CD  
11 1 Y 1 A ARG 222 ? NE  ? A ARG 222 NE  
12 1 Y 1 A ARG 222 ? CZ  ? A ARG 222 CZ  
13 1 Y 1 A ARG 222 ? NH1 ? A ARG 222 NH1 
14 1 Y 1 A ARG 222 ? NH2 ? A ARG 222 NH2 
15 1 Y 1 A ARG 298 ? CG  ? A ARG 298 CG  
16 1 Y 1 A ARG 298 ? CD  ? A ARG 298 CD  
17 1 Y 1 A ARG 298 ? NE  ? A ARG 298 NE  
18 1 Y 1 A ARG 298 ? CZ  ? A ARG 298 CZ  
19 1 Y 1 A ARG 298 ? NH1 ? A ARG 298 NH1 
20 1 Y 1 A ARG 298 ? NH2 ? A ARG 298 NH2 
21 1 Y 1 A GLN 299 ? CG  ? A GLN 299 CG  
22 1 Y 1 A GLN 299 ? CD  ? A GLN 299 CD  
23 1 Y 1 A GLN 299 ? OE1 ? A GLN 299 OE1 
24 1 Y 1 A GLN 299 ? NE2 ? A GLN 299 NE2 
25 1 Y 1 B GLU 47  ? CG  ? B GLU 47  CG  
26 1 Y 1 B GLU 47  ? CD  ? B GLU 47  CD  
27 1 Y 1 B GLU 47  ? OE1 ? B GLU 47  OE1 
28 1 Y 1 B GLU 47  ? OE2 ? B GLU 47  OE2 
29 1 Y 1 B ILE 59  ? CG1 ? B ILE 59  CG1 
30 1 Y 1 B ILE 59  ? CG2 ? B ILE 59  CG2 
31 1 Y 1 B ILE 59  ? CD1 ? B ILE 59  CD1 
32 1 Y 1 B ARG 60  ? CG  ? B ARG 60  CG  
33 1 Y 1 B ARG 60  ? CD  ? B ARG 60  CD  
34 1 Y 1 B ARG 60  ? NE  ? B ARG 60  NE  
35 1 Y 1 B ARG 60  ? CZ  ? B ARG 60  CZ  
36 1 Y 1 B ARG 60  ? NH1 ? B ARG 60  NH1 
37 1 Y 1 B ARG 60  ? NH2 ? B ARG 60  NH2 
38 1 Y 1 B GLN 69  ? CG  ? B GLN 69  CG  
39 1 Y 1 B GLN 69  ? CD  ? B GLN 69  CD  
40 1 Y 1 B GLN 69  ? OE1 ? B GLN 69  OE1 
41 1 Y 1 B GLN 69  ? NE2 ? B GLN 69  NE2 
42 1 Y 1 B ASN 72  ? CG  ? B ASN 72  CG  
43 1 Y 1 B ASN 72  ? OD1 ? B ASN 72  OD1 
44 1 Y 1 B ASN 72  ? ND2 ? B ASN 72  ND2 
45 1 Y 1 B ARG 76  ? CG  ? B ARG 76  CG  
46 1 Y 1 B ARG 76  ? CD  ? B ARG 76  CD  
47 1 Y 1 B ARG 76  ? NE  ? B ARG 76  NE  
48 1 Y 1 B ARG 76  ? CZ  ? B ARG 76  CZ  
49 1 Y 1 B ARG 76  ? NH1 ? B ARG 76  NH1 
50 1 Y 1 B ARG 76  ? NH2 ? B ARG 76  NH2 
51 1 Y 1 B LEU 141 ? CG  ? B LEU 141 CG  
52 1 Y 1 B LEU 141 ? CD1 ? B LEU 141 CD1 
53 1 Y 1 B LEU 141 ? CD2 ? B LEU 141 CD2 
54 1 Y 1 B ASN 142 ? CG  ? B ASN 142 CG  
55 1 Y 1 B ASN 142 ? OD1 ? B ASN 142 OD1 
56 1 Y 1 B ASN 142 ? ND2 ? B ASN 142 ND2 
57 1 Y 1 B ASP 153 ? CG  ? B ASP 153 CG  
58 1 Y 1 B ASP 153 ? OD1 ? B ASP 153 OD1 
59 1 Y 1 B ASP 153 ? OD2 ? B ASP 153 OD2 
60 1 Y 1 B TYR 154 ? CG  ? B TYR 154 CG  
61 1 Y 1 B TYR 154 ? CD1 ? B TYR 154 CD1 
62 1 Y 1 B TYR 154 ? CD2 ? B TYR 154 CD2 
63 1 Y 1 B TYR 154 ? CE1 ? B TYR 154 CE1 
64 1 Y 1 B TYR 154 ? CE2 ? B TYR 154 CE2 
65 1 Y 1 B TYR 154 ? CZ  ? B TYR 154 CZ  
66 1 Y 1 B TYR 154 ? OH  ? B TYR 154 OH  
67 1 Y 1 B ARG 222 ? CG  ? B ARG 222 CG  
68 1 Y 1 B ARG 222 ? CD  ? B ARG 222 CD  
69 1 Y 1 B ARG 222 ? NE  ? B ARG 222 NE  
70 1 Y 1 B ARG 222 ? CZ  ? B ARG 222 CZ  
71 1 Y 1 B ARG 222 ? NH1 ? B ARG 222 NH1 
72 1 Y 1 B ARG 222 ? NH2 ? B ARG 222 NH2 
73 1 Y 1 B LEU 232 ? CG  ? B LEU 232 CG  
74 1 Y 1 B LEU 232 ? CD1 ? B LEU 232 CD1 
75 1 Y 1 B LEU 232 ? CD2 ? B LEU 232 CD2 
76 1 Y 1 B MET 235 ? CG  ? B MET 235 CG  
77 1 Y 1 B MET 235 ? SD  ? B MET 235 SD  
78 1 Y 1 B MET 235 ? CE  ? B MET 235 CE  
79 1 Y 1 B LYS 236 ? CG  ? B LYS 236 CG  
80 1 Y 1 B LYS 236 ? CD  ? B LYS 236 CD  
81 1 Y 1 B LYS 236 ? CE  ? B LYS 236 CE  
82 1 Y 1 B LYS 236 ? NZ  ? B LYS 236 NZ  
83 1 Y 1 B LYS 269 ? CG  ? B LYS 269 CG  
84 1 Y 1 B LYS 269 ? CD  ? B LYS 269 CD  
85 1 Y 1 B LYS 269 ? CE  ? B LYS 269 CE  
86 1 Y 1 B LYS 269 ? NZ  ? B LYS 269 NZ  
87 1 Y 1 B ARG 298 ? CG  ? B ARG 298 CG  
88 1 Y 1 B ARG 298 ? CD  ? B ARG 298 CD  
89 1 Y 1 B ARG 298 ? NE  ? B ARG 298 NE  
90 1 Y 1 B ARG 298 ? CZ  ? B ARG 298 CZ  
91 1 Y 1 B ARG 298 ? NH1 ? B ARG 298 NH1 
92 1 Y 1 B ARG 298 ? NH2 ? B ARG 298 NH2 
93 1 Y 1 B VAL 303 ? CG1 ? B VAL 303 CG1 
94 1 Y 1 B VAL 303 ? CG2 ? B VAL 303 CG2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BO0 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     67.760 
_cell.length_a_esd                 ? 
_cell.length_b                     100.124 
_cell.length_b_esd                 ? 
_cell.length_c                     103.908 
_cell.length_c_esd                 ? 
_cell.volume                       704953.668 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BO0 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BO0 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.60 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          52.77 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              9.0 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '10% v/v Polyethylene glycol 200, 0.1 M BIS-TRIS propane, 18% w/v Polyethylene glycol 8,000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            294 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-02-23 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.920105 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'NSLS-II BEAMLINE 17-ID-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.920105 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   17-ID-1 
_diffrn_source.pdbx_synchrotron_site       NSLS-II 
# 
_reflns.B_iso_Wilson_estimate                          38.00 
_reflns.entry_id                                       9BO0 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.16 
_reflns.d_resolution_low                               56.76 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     38629 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.65 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                6.8 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          6.06 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.992 
_reflns.pdbx_CC_star                                   0.998 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.16 
_reflns_shell.d_res_low                                     2.237 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           0.81 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             3688 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               6.4 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.336 
_reflns_shell.pdbx_CC_star                                  0.709 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          97.39 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               43.25 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9BO0 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.16 
_refine.ls_d_res_low                             56.76 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     38550 
_refine.ls_number_reflns_R_free                  1845 
_refine.ls_number_reflns_R_work                  36705 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.64 
_refine.ls_percent_reflns_R_free                 4.79 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2204 
_refine.ls_R_factor_R_free                       0.2510 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2189 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.33 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 27.0739 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.3157 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.16 
_refine_hist.d_res_low                        56.76 
_refine_hist.number_atoms_solvent             138 
_refine_hist.number_atoms_total               4754 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4577 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         39 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0021  ? 4723 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.5067  ? 6436 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0407  ? 728  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0042  ? 835  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 13.0746 ? 1641 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.16 2.22  . . 138 2709 97.13  . . . . 0.3402 . . . . . . . . . . . 0.3478 
'X-RAY DIFFRACTION' 2.22 2.28  . . 141 2757 99.21  . . . . 0.3222 . . . . . . . . . . . 0.3532 
'X-RAY DIFFRACTION' 2.28 2.36  . . 138 2791 99.80  . . . . 0.2966 . . . . . . . . . . . 0.3438 
'X-RAY DIFFRACTION' 2.36 2.44  . . 149 2788 99.97  . . . . 0.2899 . . . . . . . . . . . 0.3168 
'X-RAY DIFFRACTION' 2.44 2.54  . . 169 2775 99.97  . . . . 0.2717 . . . . . . . . . . . 0.3236 
'X-RAY DIFFRACTION' 2.54 2.65  . . 144 2797 99.97  . . . . 0.2442 . . . . . . . . . . . 0.2873 
'X-RAY DIFFRACTION' 2.65 2.79  . . 110 2838 99.93  . . . . 0.2385 . . . . . . . . . . . 0.3079 
'X-RAY DIFFRACTION' 2.79 2.97  . . 124 2838 99.93  . . . . 0.2339 . . . . . . . . . . . 0.2615 
'X-RAY DIFFRACTION' 2.97 3.20  . . 152 2814 100.00 . . . . 0.2212 . . . . . . . . . . . 0.3042 
'X-RAY DIFFRACTION' 3.20 3.52  . . 161 2811 99.97  . . . . 0.2074 . . . . . . . . . . . 0.2518 
'X-RAY DIFFRACTION' 3.52 4.03  . . 127 2883 100.00 . . . . 0.1919 . . . . . . . . . . . 0.2306 
'X-RAY DIFFRACTION' 4.03 5.08  . . 137 2888 99.97  . . . . 0.1696 . . . . . . . . . . . 0.1897 
'X-RAY DIFFRACTION' 5.08 56.76 . . 155 3016 99.53  . . . . 0.2044 . . . . . . . . . . . 0.1978 
# 
_struct.entry_id                     9BO0 
_struct.title                        'Crystal Structure of T21I SARS-CoV-2 Main Protease in Complex with Compound Mpro61' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BO0 
_struct_keywords.text            'Hydrolase, VIRAL PROTEIN' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    R1A_SARS2 
_struct_ref.pdbx_db_accession          P0DTC1 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGH
SMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFC
YMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
;
_struct_ref.pdbx_align_begin           3264 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9BO0 A 1 ? 306 ? P0DTC1 3264 ? 3569 ? 1 306 
2 1 9BO0 B 1 ? 306 ? P0DTC1 3264 ? 3569 ? 1 306 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9BO0 ILE A 21 ? UNP P0DTC1 THR 3284 'engineered mutation' 21 1 
2 9BO0 ILE B 21 ? UNP P0DTC1 THR 3284 'engineered mutation' 21 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2490  ? 
1 MORE         -11   ? 
1 'SSA (A^2)'  24810 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 10  ? GLY A 15  ? SER A 10  GLY A 15  1 ? 6  
HELX_P HELX_P2  AA2 HIS A 41  ? CYS A 44  ? HIS A 41  CYS A 44  5 ? 4  
HELX_P HELX_P3  AA3 GLU A 47  ? ASN A 51  ? GLU A 47  ASN A 51  5 ? 5  
HELX_P HELX_P4  AA4 ASN A 53  ? ARG A 60  ? ASN A 53  ARG A 60  1 ? 8  
HELX_P HELX_P5  AA5 SER A 62  ? HIS A 64  ? SER A 62  HIS A 64  5 ? 3  
HELX_P HELX_P6  AA6 ILE A 200 ? ASN A 214 ? ILE A 200 ASN A 214 1 ? 15 
HELX_P HELX_P7  AA7 THR A 226 ? MET A 235 ? THR A 226 MET A 235 1 ? 10 
HELX_P HELX_P8  AA8 LYS A 236 ? ASN A 238 ? LYS A 236 ASN A 238 5 ? 3  
HELX_P HELX_P9  AA9 THR A 243 ? LEU A 250 ? THR A 243 LEU A 250 1 ? 8  
HELX_P HELX_P10 AB1 LEU A 250 ? GLY A 258 ? LEU A 250 GLY A 258 1 ? 9  
HELX_P HELX_P11 AB2 ALA A 260 ? GLY A 275 ? ALA A 260 GLY A 275 1 ? 16 
HELX_P HELX_P12 AB3 THR A 292 ? CYS A 300 ? THR A 292 CYS A 300 1 ? 9  
HELX_P HELX_P13 AB4 SER B 10  ? GLY B 15  ? SER B 10  GLY B 15  1 ? 6  
HELX_P HELX_P14 AB5 HIS B 41  ? CYS B 44  ? HIS B 41  CYS B 44  5 ? 4  
HELX_P HELX_P15 AB6 GLU B 47  ? ASN B 51  ? GLU B 47  ASN B 51  5 ? 5  
HELX_P HELX_P16 AB7 ASN B 53  ? ARG B 60  ? ASN B 53  ARG B 60  1 ? 8  
HELX_P HELX_P17 AB8 SER B 62  ? PHE B 66  ? SER B 62  PHE B 66  5 ? 5  
HELX_P HELX_P18 AB9 ILE B 200 ? ASN B 214 ? ILE B 200 ASN B 214 1 ? 15 
HELX_P HELX_P19 AC1 THR B 226 ? TYR B 237 ? THR B 226 TYR B 237 1 ? 12 
HELX_P HELX_P20 AC2 THR B 243 ? LEU B 250 ? THR B 243 LEU B 250 1 ? 8  
HELX_P HELX_P21 AC3 LEU B 250 ? GLY B 258 ? LEU B 250 GLY B 258 1 ? 9  
HELX_P HELX_P22 AC4 ALA B 260 ? GLY B 275 ? ALA B 260 GLY B 275 1 ? 16 
HELX_P HELX_P23 AC5 THR B 292 ? SER B 301 ? THR B 292 SER B 301 1 ? 10 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
AA4 ? 7 ? 
AA5 ? 5 ? 
AA6 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA4 5 6 ? anti-parallel 
AA4 6 7 ? anti-parallel 
AA5 1 2 ? parallel      
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA5 4 5 ? anti-parallel 
AA6 1 2 ? parallel      
AA6 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 73  ? LEU A 75  ? VAL A 73  LEU A 75  
AA1 2 PHE A 66  ? ALA A 70  ? PHE A 66  ALA A 70  
AA1 3 MET A 17  ? CYS A 22  ? MET A 17  CYS A 22  
AA1 4 THR A 25  ? LEU A 32  ? THR A 25  LEU A 32  
AA1 5 VAL A 35  ? PRO A 39  ? VAL A 35  PRO A 39  
AA1 6 VAL A 86  ? VAL A 91  ? VAL A 86  VAL A 91  
AA1 7 VAL A 77  ? GLN A 83  ? VAL A 77  GLN A 83  
AA2 1 LYS A 100 ? PHE A 103 ? LYS A 100 PHE A 103 
AA2 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA2 3 VAL A 148 ? ASP A 153 ? VAL A 148 ASP A 153 
AA2 4 THR A 111 ? TYR A 118 ? THR A 111 TYR A 118 
AA2 5 SER A 121 ? ALA A 129 ? SER A 121 ALA A 129 
AA3 1 LYS A 100 ? PHE A 103 ? LYS A 100 PHE A 103 
AA3 2 CYS A 156 ? GLU A 166 ? CYS A 156 GLU A 166 
AA3 3 HIS A 172 ? THR A 175 ? HIS A 172 THR A 175 
AA4 1 VAL B 73  ? LEU B 75  ? VAL B 73  LEU B 75  
AA4 2 LEU B 67  ? ALA B 70  ? LEU B 67  ALA B 70  
AA4 3 MET B 17  ? CYS B 22  ? MET B 17  CYS B 22  
AA4 4 THR B 25  ? LEU B 32  ? THR B 25  LEU B 32  
AA4 5 VAL B 35  ? PRO B 39  ? VAL B 35  PRO B 39  
AA4 6 VAL B 86  ? VAL B 91  ? VAL B 86  VAL B 91  
AA4 7 VAL B 77  ? GLN B 83  ? VAL B 77  GLN B 83  
AA5 1 LYS B 100 ? PHE B 103 ? LYS B 100 PHE B 103 
AA5 2 CYS B 156 ? GLU B 166 ? CYS B 156 GLU B 166 
AA5 3 VAL B 148 ? ASP B 153 ? VAL B 148 ASP B 153 
AA5 4 THR B 111 ? TYR B 118 ? THR B 111 TYR B 118 
AA5 5 SER B 121 ? ALA B 129 ? SER B 121 ALA B 129 
AA6 1 LYS B 100 ? PHE B 103 ? LYS B 100 PHE B 103 
AA6 2 CYS B 156 ? GLU B 166 ? CYS B 156 GLU B 166 
AA6 3 HIS B 172 ? THR B 175 ? HIS B 172 THR B 175 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O VAL A 73  ? O VAL A 73  N ALA A 70  ? N ALA A 70  
AA1 2 3 O LEU A 67  ? O LEU A 67  N ILE A 21  ? N ILE A 21  
AA1 3 4 N VAL A 20  ? N VAL A 20  O LEU A 27  ? O LEU A 27  
AA1 4 5 N LEU A 30  ? N LEU A 30  O TYR A 37  ? O TYR A 37  
AA1 5 6 N VAL A 36  ? N VAL A 36  O LEU A 89  ? O LEU A 89  
AA1 6 7 O LYS A 88  ? O LYS A 88  N SER A 81  ? N SER A 81  
AA2 1 2 N LYS A 100 ? N LYS A 100 O VAL A 157 ? O VAL A 157 
AA2 2 3 O SER A 158 ? O SER A 158 N ASN A 151 ? N ASN A 151 
AA2 3 4 O PHE A 150 ? O PHE A 150 N SER A 113 ? N SER A 113 
AA2 4 5 N VAL A 114 ? N VAL A 114 O TYR A 126 ? O TYR A 126 
AA3 1 2 N LYS A 100 ? N LYS A 100 O VAL A 157 ? O VAL A 157 
AA3 2 3 N MET A 165 ? N MET A 165 O ALA A 173 ? O ALA A 173 
AA4 1 2 O LEU B 75  ? O LEU B 75  N VAL B 68  ? N VAL B 68  
AA4 2 3 O LEU B 67  ? O LEU B 67  N ILE B 21  ? N ILE B 21  
AA4 3 4 N VAL B 20  ? N VAL B 20  O LEU B 27  ? O LEU B 27  
AA4 4 5 N LEU B 30  ? N LEU B 30  O TYR B 37  ? O TYR B 37  
AA4 5 6 N CYS B 38  ? N CYS B 38  O LEU B 87  ? O LEU B 87  
AA4 6 7 O LYS B 88  ? O LYS B 88  N SER B 81  ? N SER B 81  
AA5 1 2 N LYS B 100 ? N LYS B 100 O VAL B 157 ? O VAL B 157 
AA5 2 3 O SER B 158 ? O SER B 158 N ASN B 151 ? N ASN B 151 
AA5 3 4 O PHE B 150 ? O PHE B 150 N SER B 113 ? N SER B 113 
AA5 4 5 N VAL B 114 ? N VAL B 114 O TYR B 126 ? O TYR B 126 
AA6 1 2 N LYS B 100 ? N LYS B 100 O VAL B 157 ? O VAL B 157 
AA6 2 3 N MET B 165 ? N MET B 165 O ALA B 173 ? O ALA B 173 
# 
_pdbx_entry_details.entry_id                   9BO0 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 33  ? ? 54.71   -130.29 
2 1 HIS A 41  ? ? -69.55  6.55    
3 1 ASN A 84  ? ? 54.46   -125.56 
4 1 TYR A 154 ? ? 57.67   -97.54  
5 1 CYS A 300 ? ? -91.81  -103.17 
6 1 ASP B 33  ? ? 52.39   -124.53 
7 1 ASN B 51  ? ? -156.02 77.79   
8 1 ASN B 84  ? ? 54.89   -120.69 
9 1 TYR B 154 ? ? 57.07   -108.29 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A GLY 302 ? A GLY 302 
2 1 Y 1 A VAL 303 ? A VAL 303 
3 1 Y 1 A THR 304 ? A THR 304 
4 1 Y 1 A PHE 305 ? A PHE 305 
5 1 Y 1 A GLN 306 ? A GLN 306 
6 1 Y 1 B THR 304 ? B THR 304 
7 1 Y 1 B PHE 305 ? B PHE 305 
8 1 Y 1 B GLN 306 ? B GLN 306 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
GLN N    N  N N 88  
GLN CA   C  N S 89  
GLN C    C  N N 90  
GLN O    O  N N 91  
GLN CB   C  N N 92  
GLN CG   C  N N 93  
GLN CD   C  N N 94  
GLN OE1  O  N N 95  
GLN NE2  N  N N 96  
GLN OXT  O  N N 97  
GLN H    H  N N 98  
GLN H2   H  N N 99  
GLN HA   H  N N 100 
GLN HB2  H  N N 101 
GLN HB3  H  N N 102 
GLN HG2  H  N N 103 
GLN HG3  H  N N 104 
GLN HE21 H  N N 105 
GLN HE22 H  N N 106 
GLN HXT  H  N N 107 
GLU N    N  N N 108 
GLU CA   C  N S 109 
GLU C    C  N N 110 
GLU O    O  N N 111 
GLU CB   C  N N 112 
GLU CG   C  N N 113 
GLU CD   C  N N 114 
GLU OE1  O  N N 115 
GLU OE2  O  N N 116 
GLU OXT  O  N N 117 
GLU H    H  N N 118 
GLU H2   H  N N 119 
GLU HA   H  N N 120 
GLU HB2  H  N N 121 
GLU HB3  H  N N 122 
GLU HG2  H  N N 123 
GLU HG3  H  N N 124 
GLU HE2  H  N N 125 
GLU HXT  H  N N 126 
GLY N    N  N N 127 
GLY CA   C  N N 128 
GLY C    C  N N 129 
GLY O    O  N N 130 
GLY OXT  O  N N 131 
GLY H    H  N N 132 
GLY H2   H  N N 133 
GLY HA2  H  N N 134 
GLY HA3  H  N N 135 
GLY HXT  H  N N 136 
HIS N    N  N N 137 
HIS CA   C  N S 138 
HIS C    C  N N 139 
HIS O    O  N N 140 
HIS CB   C  N N 141 
HIS CG   C  Y N 142 
HIS ND1  N  Y N 143 
HIS CD2  C  Y N 144 
HIS CE1  C  Y N 145 
HIS NE2  N  Y N 146 
HIS OXT  O  N N 147 
HIS H    H  N N 148 
HIS H2   H  N N 149 
HIS HA   H  N N 150 
HIS HB2  H  N N 151 
HIS HB3  H  N N 152 
HIS HD1  H  N N 153 
HIS HD2  H  N N 154 
HIS HE1  H  N N 155 
HIS HE2  H  N N 156 
HIS HXT  H  N N 157 
HOH O    O  N N 158 
HOH H1   H  N N 159 
HOH H2   H  N N 160 
ILE N    N  N N 161 
ILE CA   C  N S 162 
ILE C    C  N N 163 
ILE O    O  N N 164 
ILE CB   C  N S 165 
ILE CG1  C  N N 166 
ILE CG2  C  N N 167 
ILE CD1  C  N N 168 
ILE OXT  O  N N 169 
ILE H    H  N N 170 
ILE H2   H  N N 171 
ILE HA   H  N N 172 
ILE HB   H  N N 173 
ILE HG12 H  N N 174 
ILE HG13 H  N N 175 
ILE HG21 H  N N 176 
ILE HG22 H  N N 177 
ILE HG23 H  N N 178 
ILE HD11 H  N N 179 
ILE HD12 H  N N 180 
ILE HD13 H  N N 181 
ILE HXT  H  N N 182 
LEU N    N  N N 183 
LEU CA   C  N S 184 
LEU C    C  N N 185 
LEU O    O  N N 186 
LEU CB   C  N N 187 
LEU CG   C  N N 188 
LEU CD1  C  N N 189 
LEU CD2  C  N N 190 
LEU OXT  O  N N 191 
LEU H    H  N N 192 
LEU H2   H  N N 193 
LEU HA   H  N N 194 
LEU HB2  H  N N 195 
LEU HB3  H  N N 196 
LEU HG   H  N N 197 
LEU HD11 H  N N 198 
LEU HD12 H  N N 199 
LEU HD13 H  N N 200 
LEU HD21 H  N N 201 
LEU HD22 H  N N 202 
LEU HD23 H  N N 203 
LEU HXT  H  N N 204 
LYS N    N  N N 205 
LYS CA   C  N S 206 
LYS C    C  N N 207 
LYS O    O  N N 208 
LYS CB   C  N N 209 
LYS CG   C  N N 210 
LYS CD   C  N N 211 
LYS CE   C  N N 212 
LYS NZ   N  N N 213 
LYS OXT  O  N N 214 
LYS H    H  N N 215 
LYS H2   H  N N 216 
LYS HA   H  N N 217 
LYS HB2  H  N N 218 
LYS HB3  H  N N 219 
LYS HG2  H  N N 220 
LYS HG3  H  N N 221 
LYS HD2  H  N N 222 
LYS HD3  H  N N 223 
LYS HE2  H  N N 224 
LYS HE3  H  N N 225 
LYS HZ1  H  N N 226 
LYS HZ2  H  N N 227 
LYS HZ3  H  N N 228 
LYS HXT  H  N N 229 
MET N    N  N N 230 
MET CA   C  N S 231 
MET C    C  N N 232 
MET O    O  N N 233 
MET CB   C  N N 234 
MET CG   C  N N 235 
MET SD   S  N N 236 
MET CE   C  N N 237 
MET OXT  O  N N 238 
MET H    H  N N 239 
MET H2   H  N N 240 
MET HA   H  N N 241 
MET HB2  H  N N 242 
MET HB3  H  N N 243 
MET HG2  H  N N 244 
MET HG3  H  N N 245 
MET HE1  H  N N 246 
MET HE2  H  N N 247 
MET HE3  H  N N 248 
MET HXT  H  N N 249 
PHE N    N  N N 250 
PHE CA   C  N S 251 
PHE C    C  N N 252 
PHE O    O  N N 253 
PHE CB   C  N N 254 
PHE CG   C  Y N 255 
PHE CD1  C  Y N 256 
PHE CD2  C  Y N 257 
PHE CE1  C  Y N 258 
PHE CE2  C  Y N 259 
PHE CZ   C  Y N 260 
PHE OXT  O  N N 261 
PHE H    H  N N 262 
PHE H2   H  N N 263 
PHE HA   H  N N 264 
PHE HB2  H  N N 265 
PHE HB3  H  N N 266 
PHE HD1  H  N N 267 
PHE HD2  H  N N 268 
PHE HE1  H  N N 269 
PHE HE2  H  N N 270 
PHE HZ   H  N N 271 
PHE HXT  H  N N 272 
PRO N    N  N N 273 
PRO CA   C  N S 274 
PRO C    C  N N 275 
PRO O    O  N N 276 
PRO CB   C  N N 277 
PRO CG   C  N N 278 
PRO CD   C  N N 279 
PRO OXT  O  N N 280 
PRO H    H  N N 281 
PRO HA   H  N N 282 
PRO HB2  H  N N 283 
PRO HB3  H  N N 284 
PRO HG2  H  N N 285 
PRO HG3  H  N N 286 
PRO HD2  H  N N 287 
PRO HD3  H  N N 288 
PRO HXT  H  N N 289 
SER N    N  N N 290 
SER CA   C  N S 291 
SER C    C  N N 292 
SER O    O  N N 293 
SER CB   C  N N 294 
SER OG   O  N N 295 
SER OXT  O  N N 296 
SER H    H  N N 297 
SER H2   H  N N 298 
SER HA   H  N N 299 
SER HB2  H  N N 300 
SER HB3  H  N N 301 
SER HG   H  N N 302 
SER HXT  H  N N 303 
THR N    N  N N 304 
THR CA   C  N S 305 
THR C    C  N N 306 
THR O    O  N N 307 
THR CB   C  N R 308 
THR OG1  O  N N 309 
THR CG2  C  N N 310 
THR OXT  O  N N 311 
THR H    H  N N 312 
THR H2   H  N N 313 
THR HA   H  N N 314 
THR HB   H  N N 315 
THR HG1  H  N N 316 
THR HG21 H  N N 317 
THR HG22 H  N N 318 
THR HG23 H  N N 319 
THR HXT  H  N N 320 
TRP N    N  N N 321 
TRP CA   C  N S 322 
TRP C    C  N N 323 
TRP O    O  N N 324 
TRP CB   C  N N 325 
TRP CG   C  Y N 326 
TRP CD1  C  Y N 327 
TRP CD2  C  Y N 328 
TRP NE1  N  Y N 329 
TRP CE2  C  Y N 330 
TRP CE3  C  Y N 331 
TRP CZ2  C  Y N 332 
TRP CZ3  C  Y N 333 
TRP CH2  C  Y N 334 
TRP OXT  O  N N 335 
TRP H    H  N N 336 
TRP H2   H  N N 337 
TRP HA   H  N N 338 
TRP HB2  H  N N 339 
TRP HB3  H  N N 340 
TRP HD1  H  N N 341 
TRP HE1  H  N N 342 
TRP HE3  H  N N 343 
TRP HZ2  H  N N 344 
TRP HZ3  H  N N 345 
TRP HH2  H  N N 346 
TRP HXT  H  N N 347 
TYR N    N  N N 348 
TYR CA   C  N S 349 
TYR C    C  N N 350 
TYR O    O  N N 351 
TYR CB   C  N N 352 
TYR CG   C  Y N 353 
TYR CD1  C  Y N 354 
TYR CD2  C  Y N 355 
TYR CE1  C  Y N 356 
TYR CE2  C  Y N 357 
TYR CZ   C  Y N 358 
TYR OH   O  N N 359 
TYR OXT  O  N N 360 
TYR H    H  N N 361 
TYR H2   H  N N 362 
TYR HA   H  N N 363 
TYR HB2  H  N N 364 
TYR HB3  H  N N 365 
TYR HD1  H  N N 366 
TYR HD2  H  N N 367 
TYR HE1  H  N N 368 
TYR HE2  H  N N 369 
TYR HH   H  N N 370 
TYR HXT  H  N N 371 
VAL N    N  N N 372 
VAL CA   C  N S 373 
VAL C    C  N N 374 
VAL O    O  N N 375 
VAL CB   C  N N 376 
VAL CG1  C  N N 377 
VAL CG2  C  N N 378 
VAL OXT  O  N N 379 
VAL H    H  N N 380 
VAL H2   H  N N 381 
VAL HA   H  N N 382 
VAL HB   H  N N 383 
VAL HG11 H  N N 384 
VAL HG12 H  N N 385 
VAL HG13 H  N N 386 
VAL HG21 H  N N 387 
VAL HG22 H  N N 388 
VAL HG23 H  N N 389 
VAL HXT  H  N N 390 
XEK C1   C  N N 391 
XEK C2   C  N N 392 
XEK C3   C  Y N 393 
XEK C4   C  Y N 394 
XEK C5   C  Y N 395 
XEK C6   C  Y N 396 
XEK C7   C  Y N 397 
XEK C8   C  N N 398 
XEK C9   C  Y N 399 
XEK C10  C  Y N 400 
XEK C11  C  Y N 401 
XEK C12  C  Y N 402 
XEK C13  C  Y N 403 
XEK C14  C  Y N 404 
XEK C15  C  Y N 405 
XEK C17  C  N N 406 
XEK C21  C  N N 407 
XEK C22  C  N N 408 
XEK C24  C  Y N 409 
XEK C25  C  Y N 410 
XEK C27  C  Y N 411 
XEK C16  C  N N 412 
XEK C18  C  N N 413 
XEK C19  C  N N 414 
XEK C20  C  N N 415 
XEK C23  C  N N 416 
XEK C26  C  Y N 417 
XEK C28  C  Y N 418 
XEK F1   F  N N 419 
XEK N1   N  N N 420 
XEK N2   N  N N 421 
XEK N3   N  N N 422 
XEK N4   N  Y N 423 
XEK O1   O  N N 424 
XEK O2   O  N N 425 
XEK O3   O  N N 426 
XEK O4   O  N N 427 
XEK CL1  CL N N 428 
XEK CL2  CL N N 429 
XEK H1   H  N N 430 
XEK H2   H  N N 431 
XEK H3   H  N N 432 
XEK H4   H  N N 433 
XEK H5   H  N N 434 
XEK H6   H  N N 435 
XEK H7   H  N N 436 
XEK H8   H  N N 437 
XEK H13  H  N N 438 
XEK H14  H  N N 439 
XEK H12  H  N N 440 
XEK H16  H  N N 441 
XEK H18  H  N N 442 
XEK H9   H  N N 443 
XEK H11  H  N N 444 
XEK H15  H  N N 445 
XEK H17  H  N N 446 
XEK H19  H  N N 447 
XEK H10  H  N N 448 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PRO N   CA   sing N N 260 
PRO N   CD   sing N N 261 
PRO N   H    sing N N 262 
PRO CA  C    sing N N 263 
PRO CA  CB   sing N N 264 
PRO CA  HA   sing N N 265 
PRO C   O    doub N N 266 
PRO C   OXT  sing N N 267 
PRO CB  CG   sing N N 268 
PRO CB  HB2  sing N N 269 
PRO CB  HB3  sing N N 270 
PRO CG  CD   sing N N 271 
PRO CG  HG2  sing N N 272 
PRO CG  HG3  sing N N 273 
PRO CD  HD2  sing N N 274 
PRO CD  HD3  sing N N 275 
PRO OXT HXT  sing N N 276 
SER N   CA   sing N N 277 
SER N   H    sing N N 278 
SER N   H2   sing N N 279 
SER CA  C    sing N N 280 
SER CA  CB   sing N N 281 
SER CA  HA   sing N N 282 
SER C   O    doub N N 283 
SER C   OXT  sing N N 284 
SER CB  OG   sing N N 285 
SER CB  HB2  sing N N 286 
SER CB  HB3  sing N N 287 
SER OG  HG   sing N N 288 
SER OXT HXT  sing N N 289 
THR N   CA   sing N N 290 
THR N   H    sing N N 291 
THR N   H2   sing N N 292 
THR CA  C    sing N N 293 
THR CA  CB   sing N N 294 
THR CA  HA   sing N N 295 
THR C   O    doub N N 296 
THR C   OXT  sing N N 297 
THR CB  OG1  sing N N 298 
THR CB  CG2  sing N N 299 
THR CB  HB   sing N N 300 
THR OG1 HG1  sing N N 301 
THR CG2 HG21 sing N N 302 
THR CG2 HG22 sing N N 303 
THR CG2 HG23 sing N N 304 
THR OXT HXT  sing N N 305 
TRP N   CA   sing N N 306 
TRP N   H    sing N N 307 
TRP N   H2   sing N N 308 
TRP CA  C    sing N N 309 
TRP CA  CB   sing N N 310 
TRP CA  HA   sing N N 311 
TRP C   O    doub N N 312 
TRP C   OXT  sing N N 313 
TRP CB  CG   sing N N 314 
TRP CB  HB2  sing N N 315 
TRP CB  HB3  sing N N 316 
TRP CG  CD1  doub Y N 317 
TRP CG  CD2  sing Y N 318 
TRP CD1 NE1  sing Y N 319 
TRP CD1 HD1  sing N N 320 
TRP CD2 CE2  doub Y N 321 
TRP CD2 CE3  sing Y N 322 
TRP NE1 CE2  sing Y N 323 
TRP NE1 HE1  sing N N 324 
TRP CE2 CZ2  sing Y N 325 
TRP CE3 CZ3  doub Y N 326 
TRP CE3 HE3  sing N N 327 
TRP CZ2 CH2  doub Y N 328 
TRP CZ2 HZ2  sing N N 329 
TRP CZ3 CH2  sing Y N 330 
TRP CZ3 HZ3  sing N N 331 
TRP CH2 HH2  sing N N 332 
TRP OXT HXT  sing N N 333 
TYR N   CA   sing N N 334 
TYR N   H    sing N N 335 
TYR N   H2   sing N N 336 
TYR CA  C    sing N N 337 
TYR CA  CB   sing N N 338 
TYR CA  HA   sing N N 339 
TYR C   O    doub N N 340 
TYR C   OXT  sing N N 341 
TYR CB  CG   sing N N 342 
TYR CB  HB2  sing N N 343 
TYR CB  HB3  sing N N 344 
TYR CG  CD1  doub Y N 345 
TYR CG  CD2  sing Y N 346 
TYR CD1 CE1  sing Y N 347 
TYR CD1 HD1  sing N N 348 
TYR CD2 CE2  doub Y N 349 
TYR CD2 HD2  sing N N 350 
TYR CE1 CZ   doub Y N 351 
TYR CE1 HE1  sing N N 352 
TYR CE2 CZ   sing Y N 353 
TYR CE2 HE2  sing N N 354 
TYR CZ  OH   sing N N 355 
TYR OH  HH   sing N N 356 
TYR OXT HXT  sing N N 357 
VAL N   CA   sing N N 358 
VAL N   H    sing N N 359 
VAL N   H2   sing N N 360 
VAL CA  C    sing N N 361 
VAL CA  CB   sing N N 362 
VAL CA  HA   sing N N 363 
VAL C   O    doub N N 364 
VAL C   OXT  sing N N 365 
VAL CB  CG1  sing N N 366 
VAL CB  CG2  sing N N 367 
VAL CB  HB   sing N N 368 
VAL CG1 HG11 sing N N 369 
VAL CG1 HG12 sing N N 370 
VAL CG1 HG13 sing N N 371 
VAL CG2 HG21 sing N N 372 
VAL CG2 HG22 sing N N 373 
VAL CG2 HG23 sing N N 374 
VAL OXT HXT  sing N N 375 
XEK O1  C1   doub N N 376 
XEK C1  C2   sing N N 377 
XEK C1  N3   sing N N 378 
XEK C2  C3   sing N N 379 
XEK C2  C16  doub N N 380 
XEK C3  C4   doub Y N 381 
XEK C3  C15  sing Y N 382 
XEK C4  C5   sing Y N 383 
XEK C5  CL1  sing N N 384 
XEK C5  C6   doub Y N 385 
XEK C6  F1   sing N N 386 
XEK C6  C7   sing Y N 387 
XEK C7  O2   sing N N 388 
XEK C7  C15  doub Y N 389 
XEK O2  C8   sing N N 390 
XEK C8  C9   sing N N 391 
XEK C9  C10  doub Y N 392 
XEK C9  C14  sing Y N 393 
XEK C10 C11  sing Y N 394 
XEK C11 C12  doub Y N 395 
XEK C12 C13  sing Y N 396 
XEK C13 C14  doub Y N 397 
XEK C14 CL2  sing N N 398 
XEK C16 C17  sing N N 399 
XEK C17 C18  sing N N 400 
XEK C17 C23  doub N N 401 
XEK C18 C19  sing N N 402 
XEK C18 C20  doub N N 403 
XEK C19 N1   sing N N 404 
XEK C19 O3   doub N N 405 
XEK N1  C22  sing N N 406 
XEK C20 N2   sing N N 407 
XEK N2  C21  sing N N 408 
XEK N2  C22  sing N N 409 
XEK C22 O4   doub N N 410 
XEK C23 N3   sing N N 411 
XEK N3  C24  sing N N 412 
XEK C24 C25  doub Y N 413 
XEK C24 C28  sing Y N 414 
XEK C25 C26  sing Y N 415 
XEK C26 C27  doub Y N 416 
XEK C27 N4   sing Y N 417 
XEK N4  C28  doub Y N 418 
XEK C4  H1   sing N N 419 
XEK C8  H2   sing N N 420 
XEK C8  H3   sing N N 421 
XEK C10 H4   sing N N 422 
XEK C11 H5   sing N N 423 
XEK C12 H6   sing N N 424 
XEK C13 H7   sing N N 425 
XEK C15 H8   sing N N 426 
XEK C21 H13  sing N N 427 
XEK C21 H14  sing N N 428 
XEK C21 H12  sing N N 429 
XEK C25 H16  sing N N 430 
XEK C27 H18  sing N N 431 
XEK C16 H9   sing N N 432 
XEK C20 H11  sing N N 433 
XEK C23 H15  sing N N 434 
XEK C26 H17  sing N N 435 
XEK C28 H19  sing N N 436 
XEK N1  H10  sing N N 437 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' 'P30 GM133893' 1 
'Department of Energy (DOE, United States)'                                                'United States' KP1607011      2 
'Other government'                                                                         ?               DE-SC0012704   3 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6Y2G 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9BO0 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.014758 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.009988 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009624 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
CL ? ? 9.50761 7.44341 ? ? 1.04373  23.83732 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
F  ? ? 4.90428 4.07044 ? ? 12.99538 1.63651  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . SER A 1 1   ? 14.03505  9.38765   -11.94262 1.000 74.67695 ? 1   SER A N   1 
ATOM   2    C  CA  . SER A 1 1   ? 13.84858  8.98142   -13.33006 1.000 67.52807 ? 1   SER A CA  1 
ATOM   3    C  C   . SER A 1 1   ? 12.78018  7.90052   -13.45228 1.000 71.27670 ? 1   SER A C   1 
ATOM   4    O  O   . SER A 1 1   ? 11.74797  7.95400   -12.78096 1.000 69.23784 ? 1   SER A O   1 
ATOM   5    C  CB  . SER A 1 1   ? 15.16636  8.48428   -13.92743 1.000 71.29879 ? 1   SER A CB  1 
ATOM   6    O  OG  . SER A 1 1   ? 15.60361  7.30202   -13.28148 1.000 70.76070 ? 1   SER A OG  1 
ATOM   7    N  N   . GLY A 1 2   ? 13.03985  6.91413   -14.30781 1.000 72.57051 ? 2   GLY A N   1 
ATOM   8    C  CA  . GLY A 1 2   ? 12.04189  5.91508   -14.63143 1.000 68.26393 ? 2   GLY A CA  1 
ATOM   9    C  C   . GLY A 1 2   ? 11.05193  6.45039   -15.64385 1.000 69.92355 ? 2   GLY A C   1 
ATOM   10   O  O   . GLY A 1 2   ? 10.83338  7.66339   -15.71916 1.000 74.03905 ? 2   GLY A O   1 
ATOM   11   N  N   . PHE A 1 3   ? 10.44672  5.56804   -16.43640 1.000 68.48222 ? 3   PHE A N   1 
ATOM   12   C  CA  . PHE A 1 3   ? 9.51181   6.01601   -17.46642 1.000 68.10759 ? 3   PHE A CA  1 
ATOM   13   C  C   . PHE A 1 3   ? 8.45198   4.93327   -17.64558 1.000 71.18376 ? 3   PHE A C   1 
ATOM   14   O  O   . PHE A 1 3   ? 8.71530   3.89938   -18.26801 1.000 71.74184 ? 3   PHE A O   1 
ATOM   15   C  CB  . PHE A 1 3   ? 10.23607  6.31301   -18.77146 1.000 65.83024 ? 3   PHE A CB  1 
ATOM   16   C  CG  . PHE A 1 3   ? 9.44618   7.16704   -19.71581 1.000 64.10598 ? 3   PHE A CG  1 
ATOM   17   C  CD1 . PHE A 1 3   ? 9.30829   8.52507   -19.48551 1.000 66.26402 ? 3   PHE A CD1 1 
ATOM   18   C  CD2 . PHE A 1 3   ? 8.83952   6.61573   -20.83131 1.000 65.34703 ? 3   PHE A CD2 1 
ATOM   19   C  CE1 . PHE A 1 3   ? 8.57916   9.31794   -20.34753 1.000 63.70745 ? 3   PHE A CE1 1 
ATOM   20   C  CE2 . PHE A 1 3   ? 8.10976   7.40544   -21.69984 1.000 64.34485 ? 3   PHE A CE2 1 
ATOM   21   C  CZ  . PHE A 1 3   ? 7.98050   8.75916   -21.45685 1.000 65.13808 ? 3   PHE A CZ  1 
ATOM   22   N  N   . ARG A 1 4   ? 7.26157   5.18139   -17.10580 1.000 65.16292 ? 4   ARG A N   1 
ATOM   23   C  CA  . ARG A 1 4   ? 6.14364   4.26004   -17.21807 1.000 55.87765 ? 4   ARG A CA  1 
ATOM   24   C  C   . ARG A 1 4   ? 4.97769   4.93029   -17.93417 1.000 47.04269 ? 4   ARG A C   1 
ATOM   25   O  O   . ARG A 1 4   ? 4.93435   6.15306   -18.09977 1.000 50.19560 ? 4   ARG A O   1 
ATOM   26   C  CB  . ARG A 1 4   ? 5.68780   3.75743   -15.84212 1.000 57.08123 ? 4   ARG A CB  1 
ATOM   27   C  CG  . ARG A 1 4   ? 6.75232   3.01188   -15.05888 1.000 57.81284 ? 4   ARG A CG  1 
ATOM   28   C  CD  . ARG A 1 4   ? 6.13900   2.33064   -13.85017 1.000 52.13831 ? 4   ARG A CD  1 
ATOM   29   N  NE  . ARG A 1 4   ? 5.35806   1.15629   -14.21990 1.000 52.98599 ? 4   ARG A NE  1 
ATOM   30   C  CZ  . ARG A 1 4   ? 5.60134   -0.07194  -13.78180 1.000 52.14241 ? 4   ARG A CZ  1 
ATOM   31   N  NH1 . ARG A 1 4   ? 6.57171   -0.31833  -12.91594 1.000 39.99808 ? 4   ARG A NH1 1 
ATOM   32   N  NH2 . ARG A 1 4   ? 4.84614   -1.07731  -14.21526 1.000 49.92121 ? 4   ARG A NH2 1 
ATOM   33   N  N   . LYS A 1 5   ? 4.02641   4.10046   -18.35352 1.000 44.84425 ? 5   LYS A N   1 
ATOM   34   C  CA  . LYS A 1 5   ? 2.81372   4.54204   -19.03873 1.000 51.60514 ? 5   LYS A CA  1 
ATOM   35   C  C   . LYS A 1 5   ? 1.81268   4.99598   -17.98171 1.000 53.30125 ? 5   LYS A C   1 
ATOM   36   O  O   . LYS A 1 5   ? 0.94255   4.23652   -17.55043 1.000 62.02012 ? 5   LYS A O   1 
ATOM   37   C  CB  . LYS A 1 5   ? 2.25558   3.40903   -19.89076 1.000 45.68409 ? 5   LYS A CB  1 
ATOM   38   C  CG  . LYS A 1 5   ? 1.64870   3.81797   -21.21772 1.000 52.32693 ? 5   LYS A CG  1 
ATOM   39   C  CD  . LYS A 1 5   ? 1.26323   2.57334   -22.00631 1.000 54.51828 ? 5   LYS A CD  1 
ATOM   40   C  CE  . LYS A 1 5   ? 0.84043   2.89995   -23.42465 1.000 55.32680 ? 5   LYS A CE  1 
ATOM   41   N  NZ  . LYS A 1 5   ? -0.47680  3.59612   -23.49820 1.000 48.80229 ? 5   LYS A NZ  1 
ATOM   42   N  N   . MET A 1 6   ? 1.93542   6.25100   -17.55231 1.000 40.72658 ? 6   MET A N   1 
ATOM   43   C  CA  . MET A 1 6   ? 1.08562   6.76678   -16.48725 1.000 39.81856 ? 6   MET A CA  1 
ATOM   44   C  C   . MET A 1 6   ? -0.25946  7.21994   -17.03701 1.000 34.46855 ? 6   MET A C   1 
ATOM   45   O  O   . MET A 1 6   ? -0.32394  7.92119   -18.05029 1.000 33.23933 ? 6   MET A O   1 
ATOM   46   C  CB  . MET A 1 6   ? 1.76517   7.92992   -15.76750 1.000 41.45368 ? 6   MET A CB  1 
ATOM   47   C  CG  . MET A 1 6   ? 3.04378   7.56727   -15.04000 1.000 53.68132 ? 6   MET A CG  1 
ATOM   48   S  SD  . MET A 1 6   ? 3.44598   8.79172   -13.77859 1.000 61.19720 ? 6   MET A SD  1 
ATOM   49   C  CE  . MET A 1 6   ? 2.93113   10.29876  -14.60369 1.000 48.13734 ? 6   MET A CE  1 
ATOM   50   N  N   . ALA A 1 7   ? -1.33014  6.82148   -16.36306 1.000 32.30918 ? 7   ALA A N   1 
ATOM   51   C  CA  . ALA A 1 7   ? -2.65686  7.33691   -16.65457 1.000 36.98022 ? 7   ALA A CA  1 
ATOM   52   C  C   . ALA A 1 7   ? -2.93202  8.56405   -15.79097 1.000 35.53544 ? 7   ALA A C   1 
ATOM   53   O  O   . ALA A 1 7   ? -2.24161  8.82770   -14.80238 1.000 36.79228 ? 7   ALA A O   1 
ATOM   54   C  CB  . ALA A 1 7   ? -3.72844  6.26988   -16.41132 1.000 27.72159 ? 7   ALA A CB  1 
ATOM   55   N  N   . PHE A 1 8   ? -3.95512  9.31454   -16.17508 1.000 30.55819 ? 8   PHE A N   1 
ATOM   56   C  CA  . PHE A 1 8   ? -4.33388  10.47650  -15.38933 1.000 30.07950 ? 8   PHE A CA  1 
ATOM   57   C  C   . PHE A 1 8   ? -5.07502  10.05151  -14.12460 1.000 27.82187 ? 8   PHE A C   1 
ATOM   58   O  O   . PHE A 1 8   ? -5.76231  9.02698   -14.11469 1.000 31.31285 ? 8   PHE A O   1 
ATOM   59   C  CB  . PHE A 1 8   ? -5.21588  11.41439  -16.20601 1.000 30.50642 ? 8   PHE A CB  1 
ATOM   60   C  CG  . PHE A 1 8   ? -4.45736  12.24877  -17.19708 1.000 34.98485 ? 8   PHE A CG  1 
ATOM   61   C  CD1 . PHE A 1 8   ? -3.74054  13.35898  -16.78037 1.000 32.92458 ? 8   PHE A CD1 1 
ATOM   62   C  CD2 . PHE A 1 8   ? -4.46497  11.92804  -18.54411 1.000 33.40440 ? 8   PHE A CD2 1 
ATOM   63   C  CE1 . PHE A 1 8   ? -3.03969  14.12967  -17.69022 1.000 40.02017 ? 8   PHE A CE1 1 
ATOM   64   C  CE2 . PHE A 1 8   ? -3.76781  12.69857  -19.45836 1.000 36.33070 ? 8   PHE A CE2 1 
ATOM   65   C  CZ  . PHE A 1 8   ? -3.05678  13.80093  -19.03059 1.000 31.09022 ? 8   PHE A CZ  1 
ATOM   66   N  N   . PRO A 1 9   ? -4.93461  10.81483  -13.04094 1.000 30.51301 ? 9   PRO A N   1 
ATOM   67   C  CA  . PRO A 1 9   ? -5.71951  10.53241  -11.82904 1.000 33.19262 ? 9   PRO A CA  1 
ATOM   68   C  C   . PRO A 1 9   ? -7.20655  10.56177  -12.14730 1.000 32.54971 ? 9   PRO A C   1 
ATOM   69   O  O   . PRO A 1 9   ? -7.73169  11.55289  -12.65754 1.000 39.38125 ? 9   PRO A O   1 
ATOM   70   C  CB  . PRO A 1 9   ? -5.30904  11.65886  -10.87190 1.000 25.46644 ? 9   PRO A CB  1 
ATOM   71   C  CG  . PRO A 1 9   ? -3.96939  12.10208  -11.36075 1.000 33.75659 ? 9   PRO A CG  1 
ATOM   72   C  CD  . PRO A 1 9   ? -4.00911  11.94524  -12.85367 1.000 27.85790 ? 9   PRO A CD  1 
ATOM   73   N  N   . SER A 1 10  ? -7.88288  9.45670   -11.84977 1.000 27.69061 ? 10  SER A N   1 
ATOM   74   C  CA  . SER A 1 10  ? -9.24113  9.22255   -12.31805 1.000 29.27592 ? 10  SER A CA  1 
ATOM   75   C  C   . SER A 1 10  ? -10.31185 9.81936   -11.41413 1.000 37.71735 ? 10  SER A C   1 
ATOM   76   O  O   . SER A 1 10  ? -11.49990 9.62754   -11.69163 1.000 37.47863 ? 10  SER A O   1 
ATOM   77   C  CB  . SER A 1 10  ? -9.48882  7.71912   -12.46322 1.000 28.00686 ? 10  SER A CB  1 
ATOM   78   O  OG  . SER A 1 10  ? -9.38974  7.07348   -11.20510 1.000 35.38730 ? 10  SER A OG  1 
ATOM   79   N  N   . GLY A 1 11  ? -9.92823  10.54389  -10.35939 1.000 28.42069 ? 11  GLY A N   1 
ATOM   80   C  CA  . GLY A 1 11  ? -10.91050 11.00685  -9.38842  1.000 32.40683 ? 11  GLY A CA  1 
ATOM   81   C  C   . GLY A 1 11  ? -12.01076 11.86091  -9.99237  1.000 30.62692 ? 11  GLY A C   1 
ATOM   82   O  O   . GLY A 1 11  ? -13.18926 11.68544  -9.67333  1.000 26.93064 ? 11  GLY A O   1 
ATOM   83   N  N   . LYS A 1 12  ? -11.64549 12.79746  -10.87087 1.000 27.62547 ? 12  LYS A N   1 
ATOM   84   C  CA  . LYS A 1 12  ? -12.63965 13.69386  -11.45207 1.000 34.19062 ? 12  LYS A CA  1 
ATOM   85   C  C   . LYS A 1 12  ? -13.61515 12.97350  -12.37736 1.000 36.65522 ? 12  LYS A C   1 
ATOM   86   O  O   . LYS A 1 12  ? -14.72401 13.47384  -12.59284 1.000 40.76707 ? 12  LYS A O   1 
ATOM   87   C  CB  . LYS A 1 12  ? -11.95041 14.82962  -12.20770 1.000 27.00610 ? 12  LYS A CB  1 
ATOM   88   C  CG  . LYS A 1 12  ? -11.07330 15.71760  -11.33092 1.000 32.38539 ? 12  LYS A CG  1 
ATOM   89   C  CD  . LYS A 1 12  ? -10.45954 16.85043  -12.13804 1.000 38.71212 ? 12  LYS A CD  1 
ATOM   90   C  CE  . LYS A 1 12  ? -9.29555  17.50327  -11.40609 1.000 42.87738 ? 12  LYS A CE  1 
ATOM   91   N  NZ  . LYS A 1 12  ? -9.72282  18.18816  -10.15758 1.000 50.03135 ? 12  LYS A NZ  1 
ATOM   92   N  N   . VAL A 1 13  ? -13.23615 11.82086  -12.92647 1.000 33.41994 ? 13  VAL A N   1 
ATOM   93   C  CA  . VAL A 1 13  ? -14.15568 11.05853  -13.76392 1.000 26.89288 ? 13  VAL A CA  1 
ATOM   94   C  C   . VAL A 1 13  ? -14.98852 10.08097  -12.93694 1.000 33.25878 ? 13  VAL A C   1 
ATOM   95   O  O   . VAL A 1 13  ? -16.15725 9.84057   -13.26018 1.000 34.47167 ? 13  VAL A O   1 
ATOM   96   C  CB  . VAL A 1 13  ? -13.38558 10.32787  -14.88012 1.000 35.65974 ? 13  VAL A CB  1 
ATOM   97   C  CG1 . VAL A 1 13  ? -14.34732 9.60035   -15.81717 1.000 30.30680 ? 13  VAL A CG1 1 
ATOM   98   C  CG2 . VAL A 1 13  ? -12.52895 11.30933  -15.66538 1.000 34.52459 ? 13  VAL A CG2 1 
ATOM   99   N  N   . GLU A 1 14  ? -14.41583 9.52047   -11.86643 1.000 31.70326 ? 14  GLU A N   1 
ATOM   100  C  CA  . GLU A 1 14  ? -15.17292 8.61295   -11.00679 1.000 32.10980 ? 14  GLU A CA  1 
ATOM   101  C  C   . GLU A 1 14  ? -16.43295 9.27993   -10.47160 1.000 31.58558 ? 14  GLU A C   1 
ATOM   102  O  O   . GLU A 1 14  ? -17.48682 8.64178   -10.36490 1.000 31.43012 ? 14  GLU A O   1 
ATOM   103  C  CB  . GLU A 1 14  ? -14.30140 8.13241   -9.84700  1.000 33.61151 ? 14  GLU A CB  1 
ATOM   104  C  CG  . GLU A 1 14  ? -13.05372 7.37393   -10.26237 1.000 26.55810 ? 14  GLU A CG  1 
ATOM   105  C  CD  . GLU A 1 14  ? -12.07982 7.20348   -9.11420  1.000 29.67627 ? 14  GLU A CD  1 
ATOM   106  O  OE1 . GLU A 1 14  ? -12.51157 6.75153   -8.03495  1.000 36.23081 ? 14  GLU A OE1 1 
ATOM   107  O  OE2 . GLU A 1 14  ? -10.88613 7.53331   -9.28585  1.000 31.40140 ? 14  GLU A OE2 1 
ATOM   108  N  N   . GLY A 1 15  ? -16.34726 10.56442  -10.13871 1.000 30.59268 ? 15  GLY A N   1 
ATOM   109  C  CA  . GLY A 1 15  ? -17.49043 11.28043  -9.61507  1.000 34.95278 ? 15  GLY A CA  1 
ATOM   110  C  C   . GLY A 1 15  ? -18.60918 11.51717  -10.60143 1.000 37.59950 ? 15  GLY A C   1 
ATOM   111  O  O   . GLY A 1 15  ? -19.63741 12.08149  -10.21704 1.000 38.23803 ? 15  GLY A O   1 
ATOM   112  N  N   . CYS A 1 16  ? -18.44417 11.10320  -11.85854 1.000 38.50522 ? 16  CYS A N   1 
ATOM   113  C  CA  . CYS A 1 16  ? -19.45418 11.30812  -12.88377 1.000 33.44219 ? 16  CYS A CA  1 
ATOM   114  C  C   . CYS A 1 16  ? -20.07284 10.01589  -13.39802 1.000 39.86128 ? 16  CYS A C   1 
ATOM   115  O  O   . CYS A 1 16  ? -21.06295 10.07744  -14.13445 1.000 32.88631 ? 16  CYS A O   1 
ATOM   116  C  CB  . CYS A 1 16  ? -18.85565 12.07735  -14.07061 1.000 32.76304 ? 16  CYS A CB  1 
ATOM   117  S  SG  . CYS A 1 16  ? -17.89649 13.53600  -13.61689 1.000 35.36145 ? 16  CYS A SG  1 
ATOM   118  N  N   . MET A 1 17  ? -19.52685 8.85698   -13.03900 1.000 33.85986 ? 17  MET A N   1 
ATOM   119  C  CA  . MET A 1 17  ? -19.99434 7.59851   -13.60311 1.000 35.21855 ? 17  MET A CA  1 
ATOM   120  C  C   . MET A 1 17  ? -21.26612 7.13713   -12.90428 1.000 34.06488 ? 17  MET A C   1 
ATOM   121  O  O   . MET A 1 17  ? -21.33567 7.11042   -11.67159 1.000 36.57358 ? 17  MET A O   1 
ATOM   122  C  CB  . MET A 1 17  ? -18.90760 6.52970   -13.49393 1.000 27.83443 ? 17  MET A CB  1 
ATOM   123  C  CG  . MET A 1 17  ? -17.61389 6.90879   -14.19156 1.000 30.15531 ? 17  MET A CG  1 
ATOM   124  S  SD  . MET A 1 17  ? -17.87793 7.53489   -15.86257 1.000 36.45918 ? 17  MET A SD  1 
ATOM   125  C  CE  . MET A 1 17  ? -18.63324 6.11893   -16.66203 1.000 28.47714 ? 17  MET A CE  1 
ATOM   126  N  N   . VAL A 1 18  ? -22.27229 6.77195   -13.69991 1.000 35.70981 ? 18  VAL A N   1 
ATOM   127  C  CA  . VAL A 1 18  ? -23.55724 6.29847   -13.20115 1.000 32.41304 ? 18  VAL A CA  1 
ATOM   128  C  C   . VAL A 1 18  ? -23.96603 5.06917   -14.00300 1.000 33.09956 ? 18  VAL A C   1 
ATOM   129  O  O   . VAL A 1 18  ? -23.35781 4.72769   -15.01968 1.000 33.79118 ? 18  VAL A O   1 
ATOM   130  C  CB  . VAL A 1 18  ? -24.65715 7.37892   -13.28540 1.000 36.34056 ? 18  VAL A CB  1 
ATOM   131  C  CG1 . VAL A 1 18  ? -24.29526 8.58068   -12.42662 1.000 35.58760 ? 18  VAL A CG1 1 
ATOM   132  C  CG2 . VAL A 1 18  ? -24.88109 7.79742   -14.73376 1.000 31.27263 ? 18  VAL A CG2 1 
ATOM   133  N  N   . GLN A 1 19  ? -25.01455 4.40436   -13.52888 1.000 30.72718 ? 19  GLN A N   1 
ATOM   134  C  CA  . GLN A 1 19  ? -25.56768 3.22897   -14.18616 1.000 35.36651 ? 19  GLN A CA  1 
ATOM   135  C  C   . GLN A 1 19  ? -26.85251 3.61238   -14.90754 1.000 40.29849 ? 19  GLN A C   1 
ATOM   136  O  O   . GLN A 1 19  ? -27.73058 4.25386   -14.32109 1.000 42.17750 ? 19  GLN A O   1 
ATOM   137  C  CB  . GLN A 1 19  ? -25.83989 2.11448   -13.17346 1.000 27.28928 ? 19  GLN A CB  1 
ATOM   138  C  CG  . GLN A 1 19  ? -26.59481 0.92686   -13.74338 1.000 35.56054 ? 19  GLN A CG  1 
ATOM   139  C  CD  . GLN A 1 19  ? -26.80511 -0.17617  -12.72329 1.000 39.82564 ? 19  GLN A CD  1 
ATOM   140  O  OE1 . GLN A 1 19  ? -25.95843 -1.05585  -12.56084 1.000 45.59721 ? 19  GLN A OE1 1 
ATOM   141  N  NE2 . GLN A 1 19  ? -27.93826 -0.13685  -12.03273 1.000 38.80642 ? 19  GLN A NE2 1 
ATOM   142  N  N   . VAL A 1 20  ? -26.95679 3.22702   -16.17638 1.000 36.41244 ? 20  VAL A N   1 
ATOM   143  C  CA  . VAL A 1 20  ? -28.15187 3.46104   -16.97871 1.000 32.30431 ? 20  VAL A CA  1 
ATOM   144  C  C   . VAL A 1 20  ? -28.76090 2.10941   -17.32102 1.000 40.27650 ? 20  VAL A C   1 
ATOM   145  O  O   . VAL A 1 20  ? -28.08765 1.24142   -17.89202 1.000 35.43316 ? 20  VAL A O   1 
ATOM   146  C  CB  . VAL A 1 20  ? -27.83874 4.26335   -18.24917 1.000 33.42110 ? 20  VAL A CB  1 
ATOM   147  C  CG1 . VAL A 1 20  ? -29.10030 4.44231   -19.08462 1.000 37.73593 ? 20  VAL A CG1 1 
ATOM   148  C  CG2 . VAL A 1 20  ? -27.23344 5.60900   -17.88580 1.000 31.82405 ? 20  VAL A CG2 1 
ATOM   149  N  N   . ILE A 1 21  ? -30.03074 1.92956   -16.96755 1.000 39.26365 ? 21  ILE A N   1 
ATOM   150  C  CA  . ILE A 1 21  ? -30.77069 0.70918   -17.25637 1.000 38.48738 ? 21  ILE A CA  1 
ATOM   151  C  C   . ILE A 1 21  ? -31.93270 1.05983   -18.17341 1.000 44.56941 ? 21  ILE A C   1 
ATOM   152  O  O   . ILE A 1 21  ? -32.60676 2.07713   -17.97778 1.000 40.42818 ? 21  ILE A O   1 
ATOM   153  C  CB  . ILE A 1 21  ? -31.27270 0.02166   -15.96762 1.000 41.21637 ? 21  ILE A CB  1 
ATOM   154  C  CG1 . ILE A 1 21  ? -30.09532 -0.51218  -15.15096 1.000 40.94093 ? 21  ILE A CG1 1 
ATOM   155  C  CG2 . ILE A 1 21  ? -32.24056 -1.10920  -16.29349 1.000 44.25321 ? 21  ILE A CG2 1 
ATOM   156  C  CD1 . ILE A 1 21  ? -30.50766 -1.28610  -13.91358 1.000 38.25905 ? 21  ILE A CD1 1 
ATOM   157  N  N   . CYS A 1 22  ? -32.14826 0.22594   -19.18782 1.000 50.64926 ? 22  CYS A N   1 
ATOM   158  C  CA  . CYS A 1 22  ? -33.29375 0.36972   -20.08185 1.000 39.61180 ? 22  CYS A CA  1 
ATOM   159  C  C   . CYS A 1 22  ? -33.69572 -1.02833  -20.52384 1.000 49.57925 ? 22  CYS A C   1 
ATOM   160  O  O   . CYS A 1 22  ? -32.98354 -1.65587  -21.31358 1.000 53.42312 ? 22  CYS A O   1 
ATOM   161  C  CB  . CYS A 1 22  ? -32.95928 1.25246   -21.28086 1.000 49.38715 ? 22  CYS A CB  1 
ATOM   162  S  SG  . CYS A 1 22  ? -34.23213 1.26457   -22.56699 1.000 52.28250 ? 22  CYS A SG  1 
ATOM   163  N  N   . GLY A 1 23  ? -34.82127 -1.51389  -20.01160 1.000 51.29442 ? 23  GLY A N   1 
ATOM   164  C  CA  . GLY A 1 23  ? -35.22375 -2.87599  -20.31525 1.000 48.57274 ? 23  GLY A CA  1 
ATOM   165  C  C   . GLY A 1 23  ? -34.24834 -3.86928  -19.71573 1.000 50.47554 ? 23  GLY A C   1 
ATOM   166  O  O   . GLY A 1 23  ? -33.95439 -3.84291  -18.51543 1.000 51.24261 ? 23  GLY A O   1 
ATOM   167  N  N   . THR A 1 24  ? -33.72689 -4.75344  -20.56159 1.000 52.26231 ? 24  THR A N   1 
ATOM   168  C  CA  . THR A 1 24  ? -32.79470 -5.79079  -20.14072 1.000 53.31953 ? 24  THR A CA  1 
ATOM   169  C  C   . THR A 1 24  ? -31.33995 -5.33534  -20.16079 1.000 55.61985 ? 24  THR A C   1 
ATOM   170  O  O   . THR A 1 24  ? -30.45018 -6.14481  -19.87623 1.000 51.00764 ? 24  THR A O   1 
ATOM   171  C  CB  . THR A 1 24  ? -32.94957 -7.02595  -21.03554 1.000 54.26221 ? 24  THR A CB  1 
ATOM   172  O  OG1 . THR A 1 24  ? -31.93469 -7.98548  -20.71442 1.000 64.23689 ? 24  THR A OG1 1 
ATOM   173  C  CG2 . THR A 1 24  ? -32.82305 -6.63689  -22.49952 1.000 52.31224 ? 24  THR A CG2 1 
ATOM   174  N  N   . THR A 1 25  ? -31.07823 -4.06966  -20.47670 1.000 56.15838 ? 25  THR A N   1 
ATOM   175  C  CA  . THR A 1 25  ? -29.72989 -3.57685  -20.72410 1.000 47.89515 ? 25  THR A CA  1 
ATOM   176  C  C   . THR A 1 25  ? -29.21516 -2.78503  -19.52818 1.000 51.21072 ? 25  THR A C   1 
ATOM   177  O  O   . THR A 1 25  ? -29.93939 -1.96918  -18.94987 1.000 42.88017 ? 25  THR A O   1 
ATOM   178  C  CB  . THR A 1 25  ? -29.70423 -2.70401  -21.98427 1.000 49.46204 ? 25  THR A CB  1 
ATOM   179  O  OG1 . THR A 1 25  ? -29.89330 -3.52665  -23.14381 1.000 51.61082 ? 25  THR A OG1 1 
ATOM   180  C  CG2 . THR A 1 25  ? -28.38795 -1.95342  -22.11027 1.000 46.64186 ? 25  THR A CG2 1 
ATOM   181  N  N   . THR A 1 26  ? -27.95783 -3.03492  -19.16159 1.000 43.04297 ? 26  THR A N   1 
ATOM   182  C  CA  . THR A 1 26  ? -27.27843 -2.30759  -18.09272 1.000 48.40383 ? 26  THR A CA  1 
ATOM   183  C  C   . THR A 1 26  ? -25.90629 -1.88358  -18.59973 1.000 47.02050 ? 26  THR A C   1 
ATOM   184  O  O   . THR A 1 26  ? -25.05380 -2.73466  -18.87249 1.000 49.15652 ? 26  THR A O   1 
ATOM   185  C  CB  . THR A 1 26  ? -27.14303 -3.16427  -16.83238 1.000 47.69551 ? 26  THR A CB  1 
ATOM   186  O  OG1 . THR A 1 26  ? -28.41542 -3.73039  -16.49341 1.000 55.50922 ? 26  THR A OG1 1 
ATOM   187  C  CG2 . THR A 1 26  ? -26.64814 -2.31767  -15.67015 1.000 44.18983 ? 26  THR A CG2 1 
ATOM   188  N  N   . LEU A 1 27  ? -25.69404 -0.57507  -18.73499 1.000 39.76389 ? 27  LEU A N   1 
ATOM   189  C  CA  . LEU A 1 27  ? -24.39985 -0.03481  -19.12659 1.000 38.32041 ? 27  LEU A CA  1 
ATOM   190  C  C   . LEU A 1 27  ? -24.14876 1.25524   -18.35467 1.000 35.81241 ? 27  LEU A C   1 
ATOM   191  O  O   . LEU A 1 27  ? -24.95970 1.67837   -17.52440 1.000 40.41294 ? 27  LEU A O   1 
ATOM   192  C  CB  . LEU A 1 27  ? -24.31446 0.18251   -20.64483 1.000 34.54416 ? 27  LEU A CB  1 
ATOM   193  C  CG  . LEU A 1 27  ? -25.49804 0.76594   -21.42124 1.000 34.86915 ? 27  LEU A CG  1 
ATOM   194  C  CD1 . LEU A 1 27  ? -25.69988 2.24599   -21.12521 1.000 33.85006 ? 27  LEU A CD1 1 
ATOM   195  C  CD2 . LEU A 1 27  ? -25.29801 0.53971   -22.91540 1.000 37.24751 ? 27  LEU A CD2 1 
ATOM   196  N  N   . ASN A 1 28  ? -23.01668 1.88802   -18.64335 1.000 29.45299 ? 28  ASN A N   1 
ATOM   197  C  CA  . ASN A 1 28  ? -22.53619 3.03166   -17.88467 1.000 27.77748 ? 28  ASN A CA  1 
ATOM   198  C  C   . ASN A 1 28  ? -22.95364 4.34254   -18.53805 1.000 28.12521 ? 28  ASN A C   1 
ATOM   199  O  O   . ASN A 1 28  ? -23.16468 4.41753   -19.75063 1.000 29.54625 ? 28  ASN A O   1 
ATOM   200  C  CB  . ASN A 1 28  ? -21.01189 2.98387   -17.75121 1.000 26.44636 ? 28  ASN A CB  1 
ATOM   201  C  CG  . ASN A 1 28  ? -20.51555 1.63950   -17.26365 1.000 30.66154 ? 28  ASN A CG  1 
ATOM   202  O  OD1 . ASN A 1 28  ? -20.59523 1.32994   -16.07552 1.000 32.93017 ? 28  ASN A OD1 1 
ATOM   203  N  ND2 . ASN A 1 28  ? -20.00305 0.82904   -18.18226 1.000 31.80509 ? 28  ASN A ND2 1 
ATOM   204  N  N   . GLY A 1 29  ? -23.06471 5.38196   -17.71133 1.000 32.87070 ? 29  GLY A N   1 
ATOM   205  C  CA  . GLY A 1 29  ? -23.36766 6.70860   -18.19493 1.000 24.79508 ? 29  GLY A CA  1 
ATOM   206  C  C   . GLY A 1 29  ? -22.43057 7.73068   -17.58800 1.000 34.04610 ? 29  GLY A C   1 
ATOM   207  O  O   . GLY A 1 29  ? -21.82149 7.51207   -16.53981 1.000 35.63784 ? 29  GLY A O   1 
ATOM   208  N  N   . LEU A 1 30  ? -22.31862 8.86694   -18.27177 1.000 34.79621 ? 30  LEU A N   1 
ATOM   209  C  CA  . LEU A 1 30  ? -21.46284 9.96886   -17.84711 1.000 36.45981 ? 30  LEU A CA  1 
ATOM   210  C  C   . LEU A 1 30  ? -22.35847 11.10401  -17.36622 1.000 35.62470 ? 30  LEU A C   1 
ATOM   211  O  O   . LEU A 1 30  ? -23.04163 11.74649  -18.17071 1.000 35.38483 ? 30  LEU A O   1 
ATOM   212  C  CB  . LEU A 1 30  ? -20.55106 10.42276  -18.98559 1.000 30.40819 ? 30  LEU A CB  1 
ATOM   213  C  CG  . LEU A 1 30  ? -19.52200 11.50161  -18.63833 1.000 31.50304 ? 30  LEU A CG  1 
ATOM   214  C  CD1 . LEU A 1 30  ? -18.48510 10.96865  -17.66353 1.000 28.52447 ? 30  LEU A CD1 1 
ATOM   215  C  CD2 . LEU A 1 30  ? -18.85895 12.03762  -19.89392 1.000 27.13289 ? 30  LEU A CD2 1 
ATOM   216  N  N   . TRP A 1 31  ? -22.35011 11.35086  -16.05833 1.000 32.02923 ? 31  TRP A N   1 
ATOM   217  C  CA  . TRP A 1 31  ? -23.22884 12.34230  -15.43926 1.000 32.58370 ? 31  TRP A CA  1 
ATOM   218  C  C   . TRP A 1 31  ? -22.47987 13.66637  -15.34475 1.000 33.33636 ? 31  TRP A C   1 
ATOM   219  O  O   . TRP A 1 31  ? -21.62926 13.85243  -14.47168 1.000 38.28386 ? 31  TRP A O   1 
ATOM   220  C  CB  . TRP A 1 31  ? -23.68931 11.85865  -14.06845 1.000 44.39934 ? 31  TRP A CB  1 
ATOM   221  C  CG  . TRP A 1 31  ? -24.73941 12.70717  -13.42620 1.000 43.40004 ? 31  TRP A CG  1 
ATOM   222  C  CD1 . TRP A 1 31  ? -25.53181 13.63814  -14.03302 1.000 48.02065 ? 31  TRP A CD1 1 
ATOM   223  C  CD2 . TRP A 1 31  ? -25.11351 12.70074  -12.04481 1.000 46.02568 ? 31  TRP A CD2 1 
ATOM   224  N  NE1 . TRP A 1 31  ? -26.37709 14.21161  -13.11354 1.000 41.53764 ? 31  TRP A NE1 1 
ATOM   225  C  CE2 . TRP A 1 31  ? -26.13923 13.65339  -11.88513 1.000 44.91376 ? 31  TRP A CE2 1 
ATOM   226  C  CE3 . TRP A 1 31  ? -24.68009 11.98190  -10.92678 1.000 41.65950 ? 31  TRP A CE3 1 
ATOM   227  C  CZ2 . TRP A 1 31  ? -26.73671 13.90605  -10.65289 1.000 45.35737 ? 31  TRP A CZ2 1 
ATOM   228  C  CZ3 . TRP A 1 31  ? -25.27352 12.23353  -9.70578  1.000 44.26404 ? 31  TRP A CZ3 1 
ATOM   229  C  CH2 . TRP A 1 31  ? -26.29115 13.18740  -9.57740  1.000 45.99558 ? 31  TRP A CH2 1 
ATOM   230  N  N   . LEU A 1 32  ? -22.79396 14.58970  -16.25040 1.000 36.93362 ? 32  LEU A N   1 
ATOM   231  C  CA  . LEU A 1 32  ? -22.23928 15.93710  -16.24094 1.000 35.37950 ? 32  LEU A CA  1 
ATOM   232  C  C   . LEU A 1 32  ? -23.38740 16.93346  -16.19029 1.000 45.70156 ? 32  LEU A C   1 
ATOM   233  O  O   . LEU A 1 32  ? -24.27573 16.90196  -17.04908 1.000 44.82149 ? 32  LEU A O   1 
ATOM   234  C  CB  . LEU A 1 32  ? -21.37144 16.19270  -17.47276 1.000 34.38327 ? 32  LEU A CB  1 
ATOM   235  C  CG  . LEU A 1 32  ? -20.17164 15.26591  -17.67820 1.000 38.20749 ? 32  LEU A CG  1 
ATOM   236  C  CD1 . LEU A 1 32  ? -19.51899 15.53895  -19.02270 1.000 32.22064 ? 32  LEU A CD1 1 
ATOM   237  C  CD2 . LEU A 1 32  ? -19.16434 15.42643  -16.54850 1.000 38.31918 ? 32  LEU A CD2 1 
ATOM   238  N  N   . ASP A 1 33  ? -23.36212 17.81606  -15.18991 1.000 50.30889 ? 33  ASP A N   1 
ATOM   239  C  CA  . ASP A 1 33  ? -24.44588 18.77444  -14.92427 1.000 47.44043 ? 33  ASP A CA  1 
ATOM   240  C  C   . ASP A 1 33  ? -25.73434 17.96260  -14.78696 1.000 41.91480 ? 33  ASP A C   1 
ATOM   241  O  O   . ASP A 1 33  ? -25.74453 16.96682  -14.04909 1.000 40.06282 ? 33  ASP A O   1 
ATOM   242  C  CB  . ASP A 1 33  ? -24.45502 19.85414  -15.99980 1.000 43.46041 ? 33  ASP A CB  1 
ATOM   243  C  CG  . ASP A 1 33  ? -23.15037 20.62561  -16.06312 1.000 47.57425 ? 33  ASP A CG  1 
ATOM   244  O  OD1 . ASP A 1 33  ? -22.50785 20.79456  -15.00668 1.000 59.84547 ? 33  ASP A OD1 1 
ATOM   245  O  OD2 . ASP A 1 33  ? -22.76428 21.06208  -17.16928 1.000 55.62758 ? 33  ASP A OD2 1 
ATOM   246  N  N   . ASP A 1 34  ? -26.81796 18.32359  -15.47563 1.000 46.33652 ? 34  ASP A N   1 
ATOM   247  C  CA  . ASP A 1 34  ? -28.06813 17.57516  -15.41933 1.000 44.30238 ? 34  ASP A CA  1 
ATOM   248  C  C   . ASP A 1 34  ? -28.27036 16.68575  -16.64404 1.000 49.20675 ? 34  ASP A C   1 
ATOM   249  O  O   . ASP A 1 34  ? -29.41193 16.39661  -17.02128 1.000 43.44737 ? 34  ASP A O   1 
ATOM   250  C  CB  . ASP A 1 34  ? -29.25015 18.53010  -15.25954 1.000 54.02514 ? 34  ASP A CB  1 
ATOM   251  C  CG  . ASP A 1 34  ? -29.52305 19.33451  -16.51550 1.000 56.94480 ? 34  ASP A CG  1 
ATOM   252  O  OD1 . ASP A 1 34  ? -28.55936 19.65426  -17.24368 1.000 55.04228 ? 34  ASP A OD1 1 
ATOM   253  O  OD2 . ASP A 1 34  ? -30.70479 19.64462  -16.77514 1.000 63.95289 ? 34  ASP A OD2 1 
ATOM   254  N  N   . VAL A 1 35  ? -27.18445 16.24478  -17.27331 1.000 44.56768 ? 35  VAL A N   1 
ATOM   255  C  CA  . VAL A 1 35  ? -27.24439 15.40124  -18.45957 1.000 43.29479 ? 35  VAL A CA  1 
ATOM   256  C  C   . VAL A 1 35  ? -26.44361 14.13259  -18.20029 1.000 45.41396 ? 35  VAL A C   1 
ATOM   257  O  O   . VAL A 1 35  ? -25.33630 14.18363  -17.65229 1.000 40.80782 ? 35  VAL A O   1 
ATOM   258  C  CB  . VAL A 1 35  ? -26.71059 16.13511  -19.70806 1.000 41.28091 ? 35  VAL A CB  1 
ATOM   259  C  CG1 . VAL A 1 35  ? -26.85253 15.25788  -20.94628 1.000 36.27919 ? 35  VAL A CG1 1 
ATOM   260  C  CG2 . VAL A 1 35  ? -27.43302 17.45964  -19.89740 1.000 41.63110 ? 35  VAL A CG2 1 
ATOM   261  N  N   . VAL A 1 36  ? -27.01065 12.99499  -18.59088 1.000 38.37236 ? 36  VAL A N   1 
ATOM   262  C  CA  . VAL A 1 36  ? -26.32799 11.70693  -18.54693 1.000 34.11104 ? 36  VAL A CA  1 
ATOM   263  C  C   . VAL A 1 36  ? -26.11532 11.24444  -19.98177 1.000 38.26642 ? 36  VAL A C   1 
ATOM   264  O  O   . VAL A 1 36  ? -27.08252 11.05982  -20.73256 1.000 36.46229 ? 36  VAL A O   1 
ATOM   265  C  CB  . VAL A 1 36  ? -27.11979 10.66663  -17.74060 1.000 29.02154 ? 36  VAL A CB  1 
ATOM   266  C  CG1 . VAL A 1 36  ? -26.53615 9.27806   -17.94784 1.000 31.34822 ? 36  VAL A CG1 1 
ATOM   267  C  CG2 . VAL A 1 36  ? -27.11669 11.03393  -16.26494 1.000 41.33522 ? 36  VAL A CG2 1 
ATOM   268  N  N   . TYR A 1 37  ? -24.85205 11.06429  -20.36120 1.000 29.83659 ? 37  TYR A N   1 
ATOM   269  C  CA  . TYR A 1 37  ? -24.47858 10.60639  -21.69288 1.000 30.85617 ? 37  TYR A CA  1 
ATOM   270  C  C   . TYR A 1 37  ? -24.19750 9.10962   -21.65251 1.000 36.73003 ? 37  TYR A C   1 
ATOM   271  O  O   . TYR A 1 37  ? -23.50811 8.62765   -20.74869 1.000 33.74355 ? 37  TYR A O   1 
ATOM   272  C  CB  . TYR A 1 37  ? -23.24220 11.35016  -22.20296 1.000 33.70162 ? 37  TYR A CB  1 
ATOM   273  C  CG  . TYR A 1 37  ? -23.34702 12.86280  -22.20243 1.000 35.91954 ? 37  TYR A CG  1 
ATOM   274  C  CD1 . TYR A 1 37  ? -23.17962 13.59356  -21.03087 1.000 38.74705 ? 37  TYR A CD1 1 
ATOM   275  C  CD2 . TYR A 1 37  ? -23.58621 13.56177  -23.37869 1.000 37.85987 ? 37  TYR A CD2 1 
ATOM   276  C  CE1 . TYR A 1 37  ? -23.26628 14.97751  -21.02895 1.000 38.42864 ? 37  TYR A CE1 1 
ATOM   277  C  CE2 . TYR A 1 37  ? -23.66940 14.94556  -23.38636 1.000 39.72253 ? 37  TYR A CE2 1 
ATOM   278  C  CZ  . TYR A 1 37  ? -23.51143 15.64662  -22.21001 1.000 42.72064 ? 37  TYR A CZ  1 
ATOM   279  O  OH  . TYR A 1 37  ? -23.59623 17.02092  -22.21833 1.000 41.44263 ? 37  TYR A OH  1 
ATOM   280  N  N   . CYS A 1 38  ? -24.71973 8.37983   -22.63092 1.000 28.29208 ? 38  CYS A N   1 
ATOM   281  C  CA  . CYS A 1 38  ? -24.49023 6.94788   -22.72773 1.000 30.23204 ? 38  CYS A CA  1 
ATOM   282  C  C   . CYS A 1 38  ? -24.65053 6.53825   -24.17909 1.000 30.72774 ? 38  CYS A C   1 
ATOM   283  O  O   . CYS A 1 38  ? -25.22099 7.29375   -24.98018 1.000 33.41767 ? 38  CYS A O   1 
ATOM   284  C  CB  . CYS A 1 38  ? -25.45349 6.16143   -21.82348 1.000 34.81914 ? 38  CYS A CB  1 
ATOM   285  S  SG  . CYS A 1 38  ? -27.17731 6.13096   -22.36193 1.000 35.76784 ? 38  CYS A SG  1 
ATOM   286  N  N   . PRO A 1 39  ? -24.14269 5.37012   -24.56982 1.000 34.41760 ? 39  PRO A N   1 
ATOM   287  C  CA  . PRO A 1 39  ? -24.33575 4.91421   -25.95014 1.000 32.58851 ? 39  PRO A CA  1 
ATOM   288  C  C   . PRO A 1 39  ? -25.81374 4.72581   -26.25753 1.000 30.90077 ? 39  PRO A C   1 
ATOM   289  O  O   . PRO A 1 39  ? -26.57346 4.21127   -25.43625 1.000 28.80748 ? 39  PRO A O   1 
ATOM   290  C  CB  . PRO A 1 39  ? -23.57808 3.58351   -25.99634 1.000 26.92076 ? 39  PRO A CB  1 
ATOM   291  C  CG  . PRO A 1 39  ? -22.59767 3.66391   -24.88356 1.000 31.08042 ? 39  PRO A CG  1 
ATOM   292  C  CD  . PRO A 1 39  ? -23.27587 4.45075   -23.80588 1.000 32.33076 ? 39  PRO A CD  1 
ATOM   293  N  N   . ARG A 1 40  ? -26.21851 5.13901   -27.46074 1.000 29.05792 ? 40  ARG A N   1 
ATOM   294  C  CA  . ARG A 1 40  ? -27.63053 5.06207   -27.82005 1.000 32.24710 ? 40  ARG A CA  1 
ATOM   295  C  C   . ARG A 1 40  ? -28.10736 3.62958   -28.02318 1.000 36.04593 ? 40  ARG A C   1 
ATOM   296  O  O   . ARG A 1 40  ? -29.31651 3.38215   -27.96256 1.000 35.50322 ? 40  ARG A O   1 
ATOM   297  C  CB  . ARG A 1 40  ? -27.91210 5.88452   -29.07786 1.000 32.49664 ? 40  ARG A CB  1 
ATOM   298  C  CG  . ARG A 1 40  ? -27.40091 5.27841   -30.37481 1.000 35.04920 ? 40  ARG A CG  1 
ATOM   299  C  CD  . ARG A 1 40  ? -27.79688 6.13382   -31.56771 1.000 34.02963 ? 40  ARG A CD  1 
ATOM   300  N  NE  . ARG A 1 40  ? -27.16055 5.69503   -32.80539 1.000 36.57107 ? 40  ARG A NE  1 
ATOM   301  C  CZ  . ARG A 1 40  ? -27.38393 6.23299   -33.99697 1.000 39.55150 ? 40  ARG A CZ  1 
ATOM   302  N  NH1 . ARG A 1 40  ? -28.23049 7.23762   -34.15459 1.000 34.96876 ? 40  ARG A NH1 1 
ATOM   303  N  NH2 . ARG A 1 40  ? -26.74624 5.74628   -35.05814 1.000 36.53992 ? 40  ARG A NH2 1 
ATOM   304  N  N   . HIS A 1 41  ? -27.19398 2.67293   -28.23323 1.000 35.74194 ? 41  HIS A N   1 
ATOM   305  C  CA  . HIS A 1 41  ? -27.65967 1.28550   -28.34955 1.000 31.36254 ? 41  HIS A CA  1 
ATOM   306  C  C   . HIS A 1 41  ? -28.17805 0.71912   -27.01342 1.000 32.72583 ? 41  HIS A C   1 
ATOM   307  O  O   . HIS A 1 41  ? -28.47865 -0.48045  -26.94782 1.000 36.75680 ? 41  HIS A O   1 
ATOM   308  C  CB  . HIS A 1 41  ? -26.54994 0.39132   -28.91645 1.000 34.62697 ? 41  HIS A CB  1 
ATOM   309  C  CG  . HIS A 1 41  ? -25.43539 0.11094   -27.95504 1.000 31.89984 ? 41  HIS A CG  1 
ATOM   310  N  ND1 . HIS A 1 41  ? -24.19965 0.71053   -28.05966 1.000 40.12691 ? 41  HIS A ND1 1 
ATOM   311  C  CD2 . HIS A 1 41  ? -25.36153 -0.71700  -26.88471 1.000 38.73664 ? 41  HIS A CD2 1 
ATOM   312  C  CE1 . HIS A 1 41  ? -23.41462 0.27006   -27.09264 1.000 36.96569 ? 41  HIS A CE1 1 
ATOM   313  N  NE2 . HIS A 1 41  ? -24.09650 -0.59446  -26.36306 1.000 39.93401 ? 41  HIS A NE2 1 
ATOM   314  N  N   . VAL A 1 42  ? -28.27893 1.54374   -25.96639 1.000 29.47289 ? 42  VAL A N   1 
ATOM   315  C  CA  . VAL A 1 42  ? -28.91130 1.10639   -24.72597 1.000 37.12767 ? 42  VAL A CA  1 
ATOM   316  C  C   . VAL A 1 42  ? -30.39057 0.82248   -24.95134 1.000 35.18952 ? 42  VAL A C   1 
ATOM   317  O  O   . VAL A 1 42  ? -30.99727 0.02547   -24.22717 1.000 40.31593 ? 42  VAL A O   1 
ATOM   318  C  CB  . VAL A 1 42  ? -28.70088 2.16542   -23.62379 1.000 36.64472 ? 42  VAL A CB  1 
ATOM   319  C  CG1 . VAL A 1 42  ? -29.44119 3.45532   -23.96383 1.000 32.42997 ? 42  VAL A CG1 1 
ATOM   320  C  CG2 . VAL A 1 42  ? -29.13402 1.63416   -22.26017 1.000 37.78305 ? 42  VAL A CG2 1 
ATOM   321  N  N   . ILE A 1 43  ? -30.99227 1.45127   -25.96808 1.000 30.32176 ? 43  ILE A N   1 
ATOM   322  C  CA  . ILE A 1 43  ? -32.42084 1.30188   -26.23086 1.000 41.44734 ? 43  ILE A CA  1 
ATOM   323  C  C   . ILE A 1 43  ? -32.73649 0.09840   -27.10386 1.000 39.75743 ? 43  ILE A C   1 
ATOM   324  O  O   . ILE A 1 43  ? -33.90928 -0.12519  -27.42820 1.000 44.50444 ? 43  ILE A O   1 
ATOM   325  C  CB  . ILE A 1 43  ? -32.99667 2.56621   -26.90379 1.000 30.51040 ? 43  ILE A CB  1 
ATOM   326  C  CG1 . ILE A 1 43  ? -32.51019 2.67257   -28.35206 1.000 35.86404 ? 43  ILE A CG1 1 
ATOM   327  C  CG2 . ILE A 1 43  ? -32.61331 3.80816   -26.11685 1.000 32.94186 ? 43  ILE A CG2 1 
ATOM   328  C  CD1 . ILE A 1 43  ? -33.00833 3.90863   -29.07160 1.000 29.16308 ? 43  ILE A CD1 1 
ATOM   329  N  N   . CYS A 1 44  ? -31.73507 -0.68373  -27.49315 1.000 44.04411 ? 44  CYS A N   1 
ATOM   330  C  CA  . CYS A 1 44  ? -31.91647 -1.77042  -28.44363 1.000 45.25545 ? 44  CYS A CA  1 
ATOM   331  C  C   . CYS A 1 44  ? -32.10593 -3.09918  -27.72948 1.000 45.17167 ? 44  CYS A C   1 
ATOM   332  O  O   . CYS A 1 44  ? -31.49208 -3.35413  -26.68973 1.000 51.93696 ? 44  CYS A O   1 
ATOM   333  C  CB  . CYS A 1 44  ? -30.71487 -1.88249  -29.38434 1.000 37.84441 ? 44  CYS A CB  1 
ATOM   334  S  SG  . CYS A 1 44  ? -30.39827 -0.43511  -30.39826 1.000 45.44845 ? 44  CYS A SG  1 
ATOM   335  N  N   . THR A 1 45  ? -32.96250 -3.94071  -28.29634 1.000 53.76550 ? 45  THR A N   1 
ATOM   336  C  CA  . THR A 1 45  ? -32.90048 -5.36153  -28.01205 1.000 57.93674 ? 45  THR A CA  1 
ATOM   337  C  C   . THR A 1 45  ? -31.84878 -6.00145  -28.91568 1.000 63.04105 ? 45  THR A C   1 
ATOM   338  O  O   . THR A 1 45  ? -31.27506 -5.35555  -29.79780 1.000 59.27126 ? 45  THR A O   1 
ATOM   339  C  CB  . THR A 1 45  ? -34.26291 -6.02211  -28.22096 1.000 55.45821 ? 45  THR A CB  1 
ATOM   340  O  OG1 . THR A 1 45  ? -34.41002 -6.38823  -29.59766 1.000 66.76337 ? 45  THR A OG1 1 
ATOM   341  C  CG2 . THR A 1 45  ? -35.38400 -5.06576  -27.84253 1.000 48.11458 ? 45  THR A CG2 1 
ATOM   342  N  N   . SER A 1 46  ? -31.59258 -7.29113  -28.69484 1.000 71.25122 ? 46  SER A N   1 
ATOM   343  C  CA  . SER A 1 46  ? -30.59034 -7.96881  -29.51015 1.000 71.89460 ? 46  SER A CA  1 
ATOM   344  C  C   . SER A 1 46  ? -31.04998 -8.11719  -30.95626 1.000 70.50672 ? 46  SER A C   1 
ATOM   345  O  O   . SER A 1 46  ? -30.21853 -8.11370  -31.87172 1.000 72.15740 ? 46  SER A O   1 
ATOM   346  C  CB  . SER A 1 46  ? -30.25538 -9.33305  -28.91012 1.000 66.63003 ? 46  SER A CB  1 
ATOM   347  O  OG  . SER A 1 46  ? -29.06923 -9.85769  -29.48143 1.000 78.09724 ? 46  SER A OG  1 
ATOM   348  N  N   . GLU A 1 47  ? -32.36202 -8.23786  -31.18266 1.000 67.17262 ? 47  GLU A N   1 
ATOM   349  C  CA  . GLU A 1 47  ? -32.87467 -8.34003  -32.54599 1.000 64.38459 ? 47  GLU A CA  1 
ATOM   350  C  C   . GLU A 1 47  ? -32.71339 -7.03089  -33.30775 1.000 62.23945 ? 47  GLU A C   1 
ATOM   351  O  O   . GLU A 1 47  ? -32.54431 -7.04378  -34.53247 1.000 72.69874 ? 47  GLU A O   1 
ATOM   352  C  CB  . GLU A 1 47  ? -34.34459 -8.76216  -32.52547 1.000 63.19644 ? 47  GLU A CB  1 
ATOM   353  N  N   . ASP A 1 48  ? -32.76092 -5.89716  -32.60544 1.000 59.94656 ? 48  ASP A N   1 
ATOM   354  C  CA  . ASP A 1 48  ? -32.59973 -4.60771  -33.26674 1.000 54.33401 ? 48  ASP A CA  1 
ATOM   355  C  C   . ASP A 1 48  ? -31.18130 -4.40386  -33.78125 1.000 54.82543 ? 48  ASP A C   1 
ATOM   356  O  O   . ASP A 1 48  ? -30.98127 -3.66995  -34.75392 1.000 59.95723 ? 48  ASP A O   1 
ATOM   357  C  CB  . ASP A 1 48  ? -32.96599 -3.47359  -32.30828 1.000 54.85983 ? 48  ASP A CB  1 
ATOM   358  C  CG  . ASP A 1 48  ? -34.42567 -3.49524  -31.90366 1.000 56.90793 ? 48  ASP A CG  1 
ATOM   359  O  OD1 . ASP A 1 48  ? -35.29527 -3.49825  -32.80018 1.000 57.96140 ? 48  ASP A OD1 1 
ATOM   360  O  OD2 . ASP A 1 48  ? -34.70194 -3.51308  -30.68454 1.000 48.74185 ? 48  ASP A OD2 1 
ATOM   361  N  N   . MET A 1 49  ? -30.19288 -5.05515  -33.16215 1.000 57.82247 ? 49  MET A N   1 
ATOM   362  C  CA  . MET A 1 49  ? -28.79652 -4.68364  -33.37168 1.000 55.92667 ? 49  MET A CA  1 
ATOM   363  C  C   . MET A 1 49  ? -28.30521 -4.91927  -34.79441 1.000 55.09941 ? 49  MET A C   1 
ATOM   364  O  O   . MET A 1 49  ? -27.26122 -4.37324  -35.16848 1.000 51.78364 ? 49  MET A O   1 
ATOM   365  C  CB  . MET A 1 49  ? -27.89478 -5.43631  -32.39168 1.000 56.59584 ? 49  MET A CB  1 
ATOM   366  C  CG  . MET A 1 49  ? -27.89419 -4.86038  -30.98634 1.000 58.92708 ? 49  MET A CG  1 
ATOM   367  S  SD  . MET A 1 49  ? -27.71389 -3.06159  -30.97532 1.000 60.40742 ? 49  MET A SD  1 
ATOM   368  C  CE  . MET A 1 49  ? -26.21195 -2.83978  -31.92549 1.000 52.70346 ? 49  MET A CE  1 
ATOM   369  N  N   . LEU A 1 50  ? -29.01709 -5.70835  -35.59705 1.000 53.57014 ? 50  LEU A N   1 
ATOM   370  C  CA  . LEU A 1 50  ? -28.54883 -5.94029  -36.95800 1.000 47.01171 ? 50  LEU A CA  1 
ATOM   371  C  C   . LEU A 1 50  ? -28.81872 -4.73463  -37.85106 1.000 45.38448 ? 50  LEU A C   1 
ATOM   372  O  O   . LEU A 1 50  ? -27.93956 -4.31214  -38.61014 1.000 45.79593 ? 50  LEU A O   1 
ATOM   373  C  CB  . LEU A 1 50  ? -29.19509 -7.20232  -37.52792 1.000 48.24888 ? 50  LEU A CB  1 
ATOM   374  C  CG  . LEU A 1 50  ? -28.22479 -8.11365  -38.28022 1.000 51.86003 ? 50  LEU A CG  1 
ATOM   375  C  CD1 . LEU A 1 50  ? -26.89720 -8.20141  -37.54385 1.000 52.34365 ? 50  LEU A CD1 1 
ATOM   376  C  CD2 . LEU A 1 50  ? -28.82333 -9.49357  -38.44259 1.000 56.56102 ? 50  LEU A CD2 1 
ATOM   377  N  N   . ASN A 1 51  ? -30.01864 -4.16468  -37.77108 1.000 37.87762 ? 51  ASN A N   1 
ATOM   378  C  CA  . ASN A 1 51  ? -30.36555 -2.94324  -38.49988 1.000 41.04742 ? 51  ASN A CA  1 
ATOM   379  C  C   . ASN A 1 51  ? -31.27501 -2.09595  -37.62405 1.000 43.64737 ? 51  ASN A C   1 
ATOM   380  O  O   . ASN A 1 51  ? -32.48630 -2.00611  -37.85485 1.000 48.06101 ? 51  ASN A O   1 
ATOM   381  C  CB  . ASN A 1 51  ? -31.03120 -3.27002  -39.83850 1.000 36.42291 ? 51  ASN A CB  1 
ATOM   382  C  CG  . ASN A 1 51  ? -30.07811 -3.91691  -40.81988 1.000 40.91165 ? 51  ASN A CG  1 
ATOM   383  O  OD1 . ASN A 1 51  ? -29.27625 -3.23768  -41.45938 1.000 39.98888 ? 51  ASN A OD1 1 
ATOM   384  N  ND2 . ASN A 1 51  ? -30.16258 -5.23527  -40.94787 1.000 33.82158 ? 51  ASN A ND2 1 
ATOM   385  N  N   . PRO A 1 52  ? -30.71685 -1.45036  -36.59900 1.000 45.52244 ? 52  PRO A N   1 
ATOM   386  C  CA  . PRO A 1 52  ? -31.54598 -0.65672  -35.68486 1.000 44.04867 ? 52  PRO A CA  1 
ATOM   387  C  C   . PRO A 1 52  ? -31.93617 0.67060   -36.31770 1.000 43.69228 ? 52  PRO A C   1 
ATOM   388  O  O   . PRO A 1 52  ? -31.09715 1.38018   -36.87898 1.000 40.01080 ? 52  PRO A O   1 
ATOM   389  C  CB  . PRO A 1 52  ? -30.63929 -0.44529  -34.46314 1.000 42.09394 ? 52  PRO A CB  1 
ATOM   390  C  CG  . PRO A 1 52  ? -29.27958 -1.01138  -34.83567 1.000 44.12308 ? 52  PRO A CG  1 
ATOM   391  C  CD  . PRO A 1 52  ? -29.28527 -1.30465  -36.30012 1.000 51.81904 ? 52  PRO A CD  1 
ATOM   392  N  N   . ASN A 1 53  ? -33.22031 0.99959   -36.22414 1.000 36.32442 ? 53  ASN A N   1 
ATOM   393  C  CA  . ASN A 1 53  ? -33.72704 2.31379   -36.60834 1.000 36.07828 ? 53  ASN A CA  1 
ATOM   394  C  C   . ASN A 1 53  ? -33.80019 3.12186   -35.31677 1.000 36.62901 ? 53  ASN A C   1 
ATOM   395  O  O   . ASN A 1 53  ? -34.80189 3.09848   -34.60158 1.000 39.13029 ? 53  ASN A O   1 
ATOM   396  C  CB  . ASN A 1 53  ? -35.07783 2.19914   -37.30494 1.000 36.45142 ? 53  ASN A CB  1 
ATOM   397  C  CG  . ASN A 1 53  ? -35.44362 3.44861   -38.07973 1.000 37.02073 ? 53  ASN A CG  1 
ATOM   398  O  OD1 . ASN A 1 53  ? -35.04110 4.55526   -37.72446 1.000 37.62159 ? 53  ASN A OD1 1 
ATOM   399  N  ND2 . ASN A 1 53  ? -36.21210 3.27587   -39.14952 1.000 46.28918 ? 53  ASN A ND2 1 
ATOM   400  N  N   . TYR A 1 54  ? -32.71175 3.83391   -35.01278 1.000 42.05395 ? 54  TYR A N   1 
ATOM   401  C  CA  . TYR A 1 54  ? -32.58277 4.47344   -33.70649 1.000 41.08398 ? 54  TYR A CA  1 
ATOM   402  C  C   . TYR A 1 54  ? -33.62199 5.56782   -33.51128 1.000 37.98113 ? 54  TYR A C   1 
ATOM   403  O  O   . TYR A 1 54  ? -34.17270 5.71477   -32.41412 1.000 38.62620 ? 54  TYR A O   1 
ATOM   404  C  CB  . TYR A 1 54  ? -31.17123 5.03104   -33.53121 1.000 41.12965 ? 54  TYR A CB  1 
ATOM   405  C  CG  . TYR A 1 54  ? -30.15172 3.96605   -33.21245 1.000 38.55292 ? 54  TYR A CG  1 
ATOM   406  C  CD1 . TYR A 1 54  ? -30.10631 3.38604   -31.95439 1.000 34.98263 ? 54  TYR A CD1 1 
ATOM   407  C  CD2 . TYR A 1 54  ? -29.24236 3.53236   -34.16905 1.000 30.02599 ? 54  TYR A CD2 1 
ATOM   408  C  CE1 . TYR A 1 54  ? -29.18348 2.41149   -31.65366 1.000 41.56056 ? 54  TYR A CE1 1 
ATOM   409  C  CE2 . TYR A 1 54  ? -28.31338 2.55478   -33.87546 1.000 34.45917 ? 54  TYR A CE2 1 
ATOM   410  C  CZ  . TYR A 1 54  ? -28.28949 1.99691   -32.61539 1.000 34.93035 ? 54  TYR A CZ  1 
ATOM   411  O  OH  . TYR A 1 54  ? -27.37064 1.02160   -32.30869 1.000 39.26108 ? 54  TYR A OH  1 
ATOM   412  N  N   . GLU A 1 55  ? -33.90100 6.34770   -34.55799 1.000 37.32226 ? 55  GLU A N   1 
ATOM   413  C  CA  . GLU A 1 55  ? -34.93951 7.36663   -34.45163 1.000 41.16113 ? 55  GLU A CA  1 
ATOM   414  C  C   . GLU A 1 55  ? -36.29011 6.73668   -34.13770 1.000 43.80205 ? 55  GLU A C   1 
ATOM   415  O  O   . GLU A 1 55  ? -37.04442 7.24708   -33.30056 1.000 34.32866 ? 55  GLU A O   1 
ATOM   416  C  CB  . GLU A 1 55  ? -35.01702 8.18456   -35.74199 1.000 38.57412 ? 55  GLU A CB  1 
ATOM   417  C  CG  . GLU A 1 55  ? -33.81077 9.07147   -36.01466 1.000 46.44022 ? 55  GLU A CG  1 
ATOM   418  C  CD  . GLU A 1 55  ? -32.66919 8.33059   -36.68922 1.000 55.76478 ? 55  GLU A CD  1 
ATOM   419  O  OE1 . GLU A 1 55  ? -32.84359 7.14326   -37.03950 1.000 50.95180 ? 55  GLU A OE1 1 
ATOM   420  O  OE2 . GLU A 1 55  ? -31.59417 8.94096   -36.87144 1.000 61.35547 ? 55  GLU A OE2 1 
ATOM   421  N  N   . ASP A 1 56  ? -36.60143 5.61300   -34.78743 1.000 39.46545 ? 56  ASP A N   1 
ATOM   422  C  CA  . ASP A 1 56  ? -37.88385 4.95323   -34.56721 1.000 37.95099 ? 56  ASP A CA  1 
ATOM   423  C  C   . ASP A 1 56  ? -37.96207 4.32661   -33.17943 1.000 42.23390 ? 56  ASP A C   1 
ATOM   424  O  O   . ASP A 1 56  ? -39.03060 4.31911   -32.55610 1.000 34.62254 ? 56  ASP A O   1 
ATOM   425  C  CB  . ASP A 1 56  ? -38.11904 3.89900   -35.64875 1.000 30.47724 ? 56  ASP A CB  1 
ATOM   426  C  CG  . ASP A 1 56  ? -39.37085 3.08302   -35.40140 1.000 39.56032 ? 56  ASP A CG  1 
ATOM   427  O  OD1 . ASP A 1 56  ? -40.48081 3.65433   -35.48173 1.000 34.55707 ? 56  ASP A OD1 1 
ATOM   428  O  OD2 . ASP A 1 56  ? -39.24586 1.87190   -35.12263 1.000 47.53420 ? 56  ASP A OD2 1 
ATOM   429  N  N   . LEU A 1 57  ? -36.84524 3.79244   -32.68083 1.000 36.43257 ? 57  LEU A N   1 
ATOM   430  C  CA  . LEU A 1 57  ? -36.85136 3.15956   -31.36608 1.000 32.36784 ? 57  LEU A CA  1 
ATOM   431  C  C   . LEU A 1 57  ? -36.93266 4.18771   -30.24475 1.000 33.85245 ? 57  LEU A C   1 
ATOM   432  O  O   . LEU A 1 57  ? -37.56616 3.93142   -29.21392 1.000 33.83246 ? 57  LEU A O   1 
ATOM   433  C  CB  . LEU A 1 57  ? -35.60173 2.29148   -31.19804 1.000 42.05435 ? 57  LEU A CB  1 
ATOM   434  C  CG  . LEU A 1 57  ? -35.46909 1.08621   -32.13278 1.000 39.91385 ? 57  LEU A CG  1 
ATOM   435  C  CD1 . LEU A 1 57  ? -34.02406 0.62161   -32.20825 1.000 45.11645 ? 57  LEU A CD1 1 
ATOM   436  C  CD2 . LEU A 1 57  ? -36.36913 -0.04351  -31.66409 1.000 44.69006 ? 57  LEU A CD2 1 
ATOM   437  N  N   . LEU A 1 58  ? -36.30307 5.35048   -30.42404 1.000 32.05496 ? 58  LEU A N   1 
ATOM   438  C  CA  . LEU A 1 58  ? -36.26618 6.34378   -29.35555 1.000 35.24910 ? 58  LEU A CA  1 
ATOM   439  C  C   . LEU A 1 58  ? -37.61142 7.04236   -29.19513 1.000 34.66268 ? 58  LEU A C   1 
ATOM   440  O  O   . LEU A 1 58  ? -38.04397 7.31669   -28.06943 1.000 35.73208 ? 58  LEU A O   1 
ATOM   441  C  CB  . LEU A 1 58  ? -35.16175 7.36296   -29.63057 1.000 36.08565 ? 58  LEU A CB  1 
ATOM   442  C  CG  . LEU A 1 58  ? -34.95654 8.44481   -28.57137 1.000 40.21372 ? 58  LEU A CG  1 
ATOM   443  C  CD1 . LEU A 1 58  ? -34.59062 7.82301   -27.22867 1.000 38.19400 ? 58  LEU A CD1 1 
ATOM   444  C  CD2 . LEU A 1 58  ? -33.89417 9.43806   -29.02029 1.000 30.98077 ? 58  LEU A CD2 1 
ATOM   445  N  N   . ILE A 1 59  ? -38.28691 7.34047   -30.30824 1.000 32.83709 ? 59  ILE A N   1 
ATOM   446  C  CA  . ILE A 1 59  ? -39.56713 8.03546   -30.24433 1.000 37.73664 ? 59  ILE A CA  1 
ATOM   447  C  C   . ILE A 1 59  ? -40.61404 7.20492   -29.51405 1.000 39.42575 ? 59  ILE A C   1 
ATOM   448  O  O   . ILE A 1 59  ? -41.58862 7.75699   -28.99138 1.000 36.89235 ? 59  ILE A O   1 
ATOM   449  C  CB  . ILE A 1 59  ? -40.03422 8.41778   -31.66740 1.000 41.49447 ? 59  ILE A CB  1 
ATOM   450  C  CG1 . ILE A 1 59  ? -41.10435 9.50930   -31.60789 1.000 44.01290 ? 59  ILE A CG1 1 
ATOM   451  C  CG2 . ILE A 1 59  ? -40.55860 7.19832   -32.41162 1.000 39.11281 ? 59  ILE A CG2 1 
ATOM   452  C  CD1 . ILE A 1 59  ? -41.34700 10.19385  -32.93238 1.000 49.12416 ? 59  ILE A CD1 1 
ATOM   453  N  N   . ARG A 1 60  ? -40.42599 5.88504   -29.44564 1.000 37.69733 ? 60  ARG A N   1 
ATOM   454  C  CA  . ARG A 1 60  ? -41.32643 5.01834   -28.69835 1.000 33.58986 ? 60  ARG A CA  1 
ATOM   455  C  C   . ARG A 1 60  ? -40.99666 4.96683   -27.21262 1.000 38.52059 ? 60  ARG A C   1 
ATOM   456  O  O   . ARG A 1 60  ? -41.74045 4.34117   -26.45045 1.000 38.14735 ? 60  ARG A O   1 
ATOM   457  C  CB  . ARG A 1 60  ? -41.29494 3.60148   -29.27928 1.000 34.74890 ? 60  ARG A CB  1 
ATOM   458  C  CG  . ARG A 1 60  ? -41.55923 3.53352   -30.77412 1.000 30.94050 ? 60  ARG A CG  1 
ATOM   459  C  CD  . ARG A 1 60  ? -41.40514 2.12076   -31.31034 1.000 28.69451 ? 60  ARG A CD  1 
ATOM   460  N  NE  . ARG A 1 60  ? -41.56366 2.07150   -32.75935 1.000 34.29388 ? 60  ARG A NE  1 
ATOM   461  C  CZ  . ARG A 1 60  ? -42.71062 1.83149   -33.37986 1.000 32.46535 ? 60  ARG A CZ  1 
ATOM   462  N  NH1 . ARG A 1 60  ? -43.82613 1.60193   -32.70605 1.000 27.13163 ? 60  ARG A NH1 1 
ATOM   463  N  NH2 . ARG A 1 60  ? -42.73972 1.82250   -34.70939 1.000 28.66706 ? 60  ARG A NH2 1 
ATOM   464  N  N   . LYS A 1 61  ? -39.91468 5.60812   -26.78535 1.000 36.71235 ? 61  LYS A N   1 
ATOM   465  C  CA  . LYS A 1 61  ? -39.46570 5.56791   -25.40141 1.000 40.16315 ? 61  LYS A CA  1 
ATOM   466  C  C   . LYS A 1 61  ? -39.99489 6.77232   -24.63478 1.000 39.70923 ? 61  LYS A C   1 
ATOM   467  O  O   . LYS A 1 61  ? -40.06675 7.88228   -25.17081 1.000 40.87237 ? 61  LYS A O   1 
ATOM   468  C  CB  . LYS A 1 61  ? -37.93641 5.54627   -25.32655 1.000 37.08994 ? 61  LYS A CB  1 
ATOM   469  C  CG  . LYS A 1 61  ? -37.34090 4.26057   -24.77762 1.000 42.51134 ? 61  LYS A CG  1 
ATOM   470  C  CD  . LYS A 1 61  ? -37.59347 3.08559   -25.70114 1.000 43.00979 ? 61  LYS A CD  1 
ATOM   471  C  CE  . LYS A 1 61  ? -36.81213 1.86299   -25.25241 1.000 49.17671 ? 61  LYS A CE  1 
ATOM   472  N  NZ  . LYS A 1 61  ? -37.06965 1.53443   -23.82389 1.000 56.24378 ? 61  LYS A NZ  1 
ATOM   473  N  N   . SER A 1 62  ? -40.35705 6.54766   -23.37634 1.000 38.10709 ? 62  SER A N   1 
ATOM   474  C  CA  . SER A 1 62  ? -40.72216 7.61548   -22.45921 1.000 47.75635 ? 62  SER A CA  1 
ATOM   475  C  C   . SER A 1 62  ? -39.66038 7.73718   -21.37291 1.000 46.90370 ? 62  SER A C   1 
ATOM   476  O  O   . SER A 1 62  ? -38.87082 6.81693   -21.14390 1.000 45.97955 ? 62  SER A O   1 
ATOM   477  C  CB  . SER A 1 62  ? -42.09900 7.36262   -21.83560 1.000 51.33929 ? 62  SER A CB  1 
ATOM   478  O  OG  . SER A 1 62  ? -42.07314 6.22183   -20.99723 1.000 57.32952 ? 62  SER A OG  1 
ATOM   479  N  N   . ASN A 1 63  ? -39.65335 8.89419   -20.70243 1.000 51.16062 ? 63  ASN A N   1 
ATOM   480  C  CA  . ASN A 1 63  ? -38.61173 9.18998   -19.72064 1.000 45.25704 ? 63  ASN A CA  1 
ATOM   481  C  C   . ASN A 1 63  ? -38.52454 8.11836   -18.64105 1.000 51.34434 ? 63  ASN A C   1 
ATOM   482  O  O   . ASN A 1 63  ? -37.42568 7.74975   -18.20968 1.000 45.18515 ? 63  ASN A O   1 
ATOM   483  C  CB  . ASN A 1 63  ? -38.86088 10.55808  -19.08490 1.000 42.62031 ? 63  ASN A CB  1 
ATOM   484  C  CG  . ASN A 1 63  ? -38.78464 11.68777  -20.08610 1.000 48.59749 ? 63  ASN A CG  1 
ATOM   485  O  OD1 . ASN A 1 63  ? -38.14413 11.56490  -21.12947 1.000 51.20226 ? 63  ASN A OD1 1 
ATOM   486  N  ND2 . ASN A 1 63  ? -39.43931 12.80059  -19.77328 1.000 41.67372 ? 63  ASN A ND2 1 
ATOM   487  N  N   . HIS A 1 64  ? -39.66793 7.59942   -18.19705 1.000 43.63067 ? 64  HIS A N   1 
ATOM   488  C  CA  . HIS A 1 64  ? -39.67238 6.61099   -17.12632 1.000 52.04828 ? 64  HIS A CA  1 
ATOM   489  C  C   . HIS A 1 64  ? -39.21356 5.23074   -17.58075 1.000 43.15175 ? 64  HIS A C   1 
ATOM   490  O  O   . HIS A 1 64  ? -39.11155 4.32822   -16.74336 1.000 41.72556 ? 64  HIS A O   1 
ATOM   491  C  CB  . HIS A 1 64  ? -41.06545 6.51849   -16.49094 1.000 47.97308 ? 64  HIS A CB  1 
ATOM   492  C  CG  . HIS A 1 64  ? -42.14979 6.12948   -17.44647 1.000 50.04018 ? 64  HIS A CG  1 
ATOM   493  N  ND1 . HIS A 1 64  ? -42.44065 4.81626   -17.74845 1.000 53.07840 ? 64  HIS A ND1 1 
ATOM   494  C  CD2 . HIS A 1 64  ? -43.02595 6.88127   -18.15441 1.000 51.82306 ? 64  HIS A CD2 1 
ATOM   495  C  CE1 . HIS A 1 64  ? -43.44468 4.77582   -18.60640 1.000 50.00523 ? 64  HIS A CE1 1 
ATOM   496  N  NE2 . HIS A 1 64  ? -43.81728 6.01550   -18.87005 1.000 52.12291 ? 64  HIS A NE2 1 
ATOM   497  N  N   . ASN A 1 65  ? -38.93059 5.03964   -18.87183 1.000 45.24764 ? 65  ASN A N   1 
ATOM   498  C  CA  . ASN A 1 65  ? -38.33837 3.78290   -19.31613 1.000 44.12251 ? 65  ASN A CA  1 
ATOM   499  C  C   . ASN A 1 65  ? -36.85951 3.68659   -18.96274 1.000 41.42861 ? 65  ASN A C   1 
ATOM   500  O  O   . ASN A 1 65  ? -36.29745 2.58691   -18.99600 1.000 40.07253 ? 65  ASN A O   1 
ATOM   501  C  CB  . ASN A 1 65  ? -38.51436 3.61305   -20.82730 1.000 41.04759 ? 65  ASN A CB  1 
ATOM   502  C  CG  . ASN A 1 65  ? -39.96277 3.41564   -21.23166 1.000 51.88701 ? 65  ASN A CG  1 
ATOM   503  O  OD1 . ASN A 1 65  ? -40.52814 4.22009   -21.97188 1.000 47.16174 ? 65  ASN A OD1 1 
ATOM   504  N  ND2 . ASN A 1 65  ? -40.56832 2.33544   -20.75359 1.000 55.54432 ? 65  ASN A ND2 1 
ATOM   505  N  N   . PHE A 1 66  ? -36.22272 4.80475   -18.62463 1.000 43.67291 ? 66  PHE A N   1 
ATOM   506  C  CA  . PHE A 1 66  ? -34.79186 4.84951   -18.34965 1.000 45.80857 ? 66  PHE A CA  1 
ATOM   507  C  C   . PHE A 1 66  ? -34.55945 4.91422   -16.84474 1.000 49.79847 ? 66  PHE A C   1 
ATOM   508  O  O   . PHE A 1 66  ? -35.00908 5.85584   -16.18303 1.000 47.24842 ? 66  PHE A O   1 
ATOM   509  C  CB  . PHE A 1 66  ? -34.14234 6.04979   -19.03852 1.000 40.78304 ? 66  PHE A CB  1 
ATOM   510  C  CG  . PHE A 1 66  ? -34.17740 5.98157   -20.53670 1.000 42.25121 ? 66  PHE A CG  1 
ATOM   511  C  CD1 . PHE A 1 66  ? -33.22806 5.24896   -21.23031 1.000 37.17192 ? 66  PHE A CD1 1 
ATOM   512  C  CD2 . PHE A 1 66  ? -35.15390 6.65524   -21.25332 1.000 41.79689 ? 66  PHE A CD2 1 
ATOM   513  C  CE1 . PHE A 1 66  ? -33.25474 5.18298   -22.61099 1.000 49.79534 ? 66  PHE A CE1 1 
ATOM   514  C  CE2 . PHE A 1 66  ? -35.18623 6.59382   -22.63622 1.000 45.18807 ? 66  PHE A CE2 1 
ATOM   515  C  CZ  . PHE A 1 66  ? -34.23488 5.85701   -23.31543 1.000 45.16166 ? 66  PHE A CZ  1 
ATOM   516  N  N   . LEU A 1 67  ? -33.84758 3.92354   -16.31369 1.000 47.49063 ? 67  LEU A N   1 
ATOM   517  C  CA  . LEU A 1 67  ? -33.49419 3.87143   -14.90093 1.000 43.18141 ? 67  LEU A CA  1 
ATOM   518  C  C   . LEU A 1 67  ? -32.04061 4.30300   -14.73754 1.000 43.94737 ? 67  LEU A C   1 
ATOM   519  O  O   . LEU A 1 67  ? -31.12921 3.62841   -15.22930 1.000 40.96620 ? 67  LEU A O   1 
ATOM   520  C  CB  . LEU A 1 67  ? -33.70523 2.46513   -14.33953 1.000 40.17861 ? 67  LEU A CB  1 
ATOM   521  C  CG  . LEU A 1 67  ? -35.06089 1.80905   -14.61405 1.000 52.41437 ? 67  LEU A CG  1 
ATOM   522  C  CD1 . LEU A 1 67  ? -35.09130 0.39021   -14.06222 1.000 55.90811 ? 67  LEU A CD1 1 
ATOM   523  C  CD2 . LEU A 1 67  ? -36.20073 2.63979   -14.03815 1.000 50.60965 ? 67  LEU A CD2 1 
ATOM   524  N  N   . VAL A 1 68  ? -31.82806 5.42569   -14.05694 1.000 44.56290 ? 68  VAL A N   1 
ATOM   525  C  CA  . VAL A 1 68  ? -30.49629 5.95794   -13.79363 1.000 45.55953 ? 68  VAL A CA  1 
ATOM   526  C  C   . VAL A 1 68  ? -30.24012 5.87812   -12.29685 1.000 50.05772 ? 68  VAL A C   1 
ATOM   527  O  O   . VAL A 1 68  ? -31.09022 6.28249   -11.49399 1.000 53.93342 ? 68  VAL A O   1 
ATOM   528  C  CB  . VAL A 1 68  ? -30.35331 7.40370   -14.29867 1.000 41.83331 ? 68  VAL A CB  1 
ATOM   529  C  CG1 . VAL A 1 68  ? -28.95184 7.92682   -14.01809 1.000 35.79395 ? 68  VAL A CG1 1 
ATOM   530  C  CG2 . VAL A 1 68  ? -30.66829 7.47635   -15.78095 1.000 41.47092 ? 68  VAL A CG2 1 
ATOM   531  N  N   . GLN A 1 69  ? -29.07265 5.35788   -11.92171 1.000 39.34888 ? 69  GLN A N   1 
ATOM   532  C  CA  . GLN A 1 69  ? -28.69301 5.21500   -10.52092 1.000 45.77195 ? 69  GLN A CA  1 
ATOM   533  C  C   . GLN A 1 69  ? -27.27638 5.73261   -10.32640 1.000 46.32115 ? 69  GLN A C   1 
ATOM   534  O  O   . GLN A 1 69  ? -26.34064 5.24883   -10.97244 1.000 43.77067 ? 69  GLN A O   1 
ATOM   535  C  CB  . GLN A 1 69  ? -28.80146 3.75762   -10.06292 1.000 45.32748 ? 69  GLN A CB  1 
ATOM   536  C  CG  . GLN A 1 69  ? -30.21346 3.33950   -9.68589  1.000 65.46334 ? 69  GLN A CG  1 
ATOM   537  C  CD  . GLN A 1 69  ? -30.33444 1.85268   -9.41741  1.000 73.61042 ? 69  GLN A CD  1 
ATOM   538  O  OE1 . GLN A 1 69  ? -31.33689 1.22856   -9.76897  1.000 64.22670 ? 69  GLN A OE1 1 
ATOM   539  N  NE2 . GLN A 1 69  ? -29.31462 1.27697   -8.78883  1.000 63.02091 ? 69  GLN A NE2 1 
ATOM   540  N  N   . ALA A 1 70  ? -27.12582 6.71609   -9.44271  1.000 42.85836 ? 70  ALA A N   1 
ATOM   541  C  CA  . ALA A 1 70  ? -25.82813 7.24556   -9.03311  1.000 44.28833 ? 70  ALA A CA  1 
ATOM   542  C  C   . ALA A 1 70  ? -25.60389 6.79768   -7.59420  1.000 52.44578 ? 70  ALA A C   1 
ATOM   543  O  O   . ALA A 1 70  ? -26.13734 7.39947   -6.65760  1.000 54.94757 ? 70  ALA A O   1 
ATOM   544  C  CB  . ALA A 1 70  ? -25.78519 8.76430   -9.16290  1.000 43.41381 ? 70  ALA A CB  1 
ATOM   545  N  N   . GLY A 1 71  ? -24.81842 5.74053   -7.42091  1.000 53.59327 ? 71  GLY A N   1 
ATOM   546  C  CA  . GLY A 1 71  ? -24.68947 5.15479   -6.09774  1.000 50.86818 ? 71  GLY A CA  1 
ATOM   547  C  C   . GLY A 1 71  ? -26.01901 4.57186   -5.66559  1.000 53.35116 ? 71  GLY A C   1 
ATOM   548  O  O   . GLY A 1 71  ? -26.68764 3.86219   -6.42521  1.000 59.97514 ? 71  GLY A O   1 
ATOM   549  N  N   . ASN A 1 72  ? -26.42121 4.87597   -4.43358  1.000 60.31080 ? 72  ASN A N   1 
ATOM   550  C  CA  . ASN A 1 72  ? -27.72801 4.45865   -3.94198  1.000 67.17741 ? 72  ASN A CA  1 
ATOM   551  C  C   . ASN A 1 72  ? -28.83873 5.43005   -4.32221  1.000 63.36534 ? 72  ASN A C   1 
ATOM   552  O  O   . ASN A 1 72  ? -29.99699 5.19347   -3.96184  1.000 72.88587 ? 72  ASN A O   1 
ATOM   553  C  CB  . ASN A 1 72  ? -27.69039 4.27710   -2.41910  1.000 70.66730 ? 72  ASN A CB  1 
ATOM   554  C  CG  . ASN A 1 72  ? -27.21435 5.52097   -1.68629  1.000 73.05219 ? 72  ASN A CG  1 
ATOM   555  O  OD1 . ASN A 1 72  ? -27.26406 6.63123   -2.21441  1.000 75.76434 ? 72  ASN A OD1 1 
ATOM   556  N  ND2 . ASN A 1 72  ? -26.75056 5.33592   -0.45602  1.000 80.93906 ? 72  ASN A ND2 1 
ATOM   557  N  N   . VAL A 1 73  ? -28.51788 6.50476   -5.03927  1.000 61.74635 ? 73  VAL A N   1 
ATOM   558  C  CA  . VAL A 1 73  ? -29.48926 7.51744   -5.43661  1.000 57.27399 ? 73  VAL A CA  1 
ATOM   559  C  C   . VAL A 1 73  ? -29.97983 7.20659   -6.84337  1.000 58.86768 ? 73  VAL A C   1 
ATOM   560  O  O   . VAL A 1 73  ? -29.17535 7.04380   -7.77017  1.000 51.80629 ? 73  VAL A O   1 
ATOM   561  C  CB  . VAL A 1 73  ? -28.88010 8.92800   -5.36966  1.000 43.97063 ? 73  VAL A CB  1 
ATOM   562  C  CG1 . VAL A 1 73  ? -29.81949 9.93842   -6.00849  1.000 52.33124 ? 73  VAL A CG1 1 
ATOM   563  C  CG2 . VAL A 1 73  ? -28.58020 9.30563   -3.92918  1.000 46.38550 ? 73  VAL A CG2 1 
ATOM   564  N  N   . GLN A 1 74  ? -31.29752 7.12277   -7.00571  1.000 57.64191 ? 74  GLN A N   1 
ATOM   565  C  CA  . GLN A 1 74  ? -31.90660 6.95322   -8.31857  1.000 53.60141 ? 74  GLN A CA  1 
ATOM   566  C  C   . GLN A 1 74  ? -32.29976 8.31921   -8.86909  1.000 47.30312 ? 74  GLN A C   1 
ATOM   567  O  O   . GLN A 1 74  ? -33.12641 9.01907   -8.27509  1.000 57.38896 ? 74  GLN A O   1 
ATOM   568  C  CB  . GLN A 1 74  ? -33.12298 6.03098   -8.24300  1.000 50.19504 ? 74  GLN A CB  1 
ATOM   569  C  CG  . GLN A 1 74  ? -34.02083 6.10086   -9.46949  1.000 61.80127 ? 74  GLN A CG  1 
ATOM   570  C  CD  . GLN A 1 74  ? -35.11808 5.05467   -9.45609  1.000 75.95952 ? 74  GLN A CD  1 
ATOM   571  O  OE1 . GLN A 1 74  ? -34.86601 3.87648   -9.20124  1.000 75.36018 ? 74  GLN A OE1 1 
ATOM   572  N  NE2 . GLN A 1 74  ? -36.34639 5.48187   -9.73019  1.000 72.62239 ? 74  GLN A NE2 1 
ATOM   573  N  N   . LEU A 1 75  ? -31.70296 8.69761   -9.99517  1.000 51.35167 ? 75  LEU A N   1 
ATOM   574  C  CA  . LEU A 1 75  ? -32.05250 9.94446   -10.65673 1.000 47.58429 ? 75  LEU A CA  1 
ATOM   575  C  C   . LEU A 1 75  ? -33.32238 9.76807   -11.47971 1.000 54.00427 ? 75  LEU A C   1 
ATOM   576  O  O   . LEU A 1 75  ? -33.57948 8.70195   -12.04690 1.000 50.20255 ? 75  LEU A O   1 
ATOM   577  C  CB  . LEU A 1 75  ? -30.91161 10.41717  -11.55935 1.000 46.72410 ? 75  LEU A CB  1 
ATOM   578  C  CG  . LEU A 1 75  ? -29.56270 10.70024  -10.89579 1.000 52.58488 ? 75  LEU A CG  1 
ATOM   579  C  CD1 . LEU A 1 75  ? -28.49946 10.96266  -11.94955 1.000 48.25791 ? 75  LEU A CD1 1 
ATOM   580  C  CD2 . LEU A 1 75  ? -29.67109 11.87759  -9.94117  1.000 46.03588 ? 75  LEU A CD2 1 
ATOM   581  N  N   . ARG A 1 76  ? -34.12186 10.82828  -11.53852 1.000 55.39211 ? 76  ARG A N   1 
ATOM   582  C  CA  . ARG A 1 76  ? -35.36068 10.83010  -12.30408 1.000 50.07469 ? 76  ARG A CA  1 
ATOM   583  C  C   . ARG A 1 76  ? -35.09806 11.46878  -13.66128 1.000 48.41064 ? 76  ARG A C   1 
ATOM   584  O  O   . ARG A 1 76  ? -34.66028 12.62265  -13.73517 1.000 47.95767 ? 76  ARG A O   1 
ATOM   585  C  CB  . ARG A 1 76  ? -36.46787 11.57529  -11.55880 1.000 58.10882 ? 76  ARG A CB  1 
ATOM   586  C  CG  . ARG A 1 76  ? -37.80088 11.60536  -12.29526 1.000 58.60782 ? 76  ARG A CG  1 
ATOM   587  C  CD  . ARG A 1 76  ? -38.90565 12.15274  -11.40573 1.000 58.53258 ? 76  ARG A CD  1 
ATOM   588  N  NE  . ARG A 1 76  ? -38.59210 13.48676  -10.90815 1.000 72.64215 ? 76  ARG A NE  1 
ATOM   589  C  CZ  . ARG A 1 76  ? -39.10493 14.60876  -11.39432 1.000 71.05905 ? 76  ARG A CZ  1 
ATOM   590  N  NH1 . ARG A 1 76  ? -39.98043 14.59622  -12.38647 1.000 62.80084 ? 76  ARG A NH1 1 
ATOM   591  N  NH2 . ARG A 1 76  ? -38.73383 15.77249  -10.86838 1.000 66.43835 ? 76  ARG A NH2 1 
ATOM   592  N  N   . VAL A 1 77  ? -35.35673 10.71651  -14.72616 1.000 37.28320 ? 77  VAL A N   1 
ATOM   593  C  CA  . VAL A 1 77  ? -35.18708 11.22157  -16.08415 1.000 43.51277 ? 77  VAL A CA  1 
ATOM   594  C  C   . VAL A 1 77  ? -36.39834 12.07460  -16.44093 1.000 47.13834 ? 77  VAL A C   1 
ATOM   595  O  O   . VAL A 1 77  ? -37.54260 11.61676  -16.34988 1.000 45.53871 ? 77  VAL A O   1 
ATOM   596  C  CB  . VAL A 1 77  ? -35.00598 10.07091  -17.08388 1.000 46.19753 ? 77  VAL A CB  1 
ATOM   597  C  CG1 . VAL A 1 77  ? -34.85727 10.61519  -18.49709 1.000 47.91125 ? 77  VAL A CG1 1 
ATOM   598  C  CG2 . VAL A 1 77  ? -33.80346 9.21661   -16.70004 1.000 47.12070 ? 77  VAL A CG2 1 
ATOM   599  N  N   . ILE A 1 78  ? -36.14871 13.31838  -16.84540 1.000 42.80351 ? 78  ILE A N   1 
ATOM   600  C  CA  . ILE A 1 78  ? -37.20515 14.25649  -17.20119 1.000 47.10950 ? 78  ILE A CA  1 
ATOM   601  C  C   . ILE A 1 78  ? -37.17651 14.60258  -18.68379 1.000 52.09739 ? 78  ILE A C   1 
ATOM   602  O  O   . ILE A 1 78  ? -37.89139 15.51117  -19.11956 1.000 44.80972 ? 78  ILE A O   1 
ATOM   603  C  CB  . ILE A 1 78  ? -37.13313 15.52971  -16.34235 1.000 51.89154 ? 78  ILE A CB  1 
ATOM   604  C  CG1 . ILE A 1 78  ? -35.82679 16.27797  -16.61063 1.000 46.86790 ? 78  ILE A CG1 1 
ATOM   605  C  CG2 . ILE A 1 78  ? -37.25919 15.18694  -14.86241 1.000 49.73874 ? 78  ILE A CG2 1 
ATOM   606  C  CD1 . ILE A 1 78  ? -35.68060 17.55222  -15.81199 1.000 44.98913 ? 78  ILE A CD1 1 
ATOM   607  N  N   . GLY A 1 79  ? -36.36913 13.89903  -19.47220 1.000 52.68740 ? 79  GLY A N   1 
ATOM   608  C  CA  . GLY A 1 79  ? -36.29208 14.14461  -20.89794 1.000 47.13724 ? 79  GLY A CA  1 
ATOM   609  C  C   . GLY A 1 79  ? -35.14285 13.40151  -21.54498 1.000 49.49150 ? 79  GLY A C   1 
ATOM   610  O  O   . GLY A 1 79  ? -34.20705 12.97912  -20.85875 1.000 48.52841 ? 79  GLY A O   1 
ATOM   611  N  N   . HIS A 1 80  ? -35.20073 13.22609  -22.86306 1.000 51.32479 ? 80  HIS A N   1 
ATOM   612  C  CA  . HIS A 1 80  ? -34.11600 12.57704  -23.58143 1.000 47.65906 ? 80  HIS A CA  1 
ATOM   613  C  C   . HIS A 1 80  ? -34.06211 13.11050  -25.00398 1.000 45.80226 ? 80  HIS A C   1 
ATOM   614  O  O   . HIS A 1 80  ? -35.07359 13.54343  -25.56182 1.000 42.36782 ? 80  HIS A O   1 
ATOM   615  C  CB  . HIS A 1 80  ? -34.26409 11.04755  -23.58932 1.000 33.63765 ? 80  HIS A CB  1 
ATOM   616  C  CG  . HIS A 1 80  ? -35.51658 10.55657  -24.24765 1.000 52.61471 ? 80  HIS A CG  1 
ATOM   617  N  ND1 . HIS A 1 80  ? -35.74248 10.67034  -25.60312 1.000 53.13374 ? 80  HIS A ND1 1 
ATOM   618  C  CD2 . HIS A 1 80  ? -36.60571 9.93412   -23.73695 1.000 53.38976 ? 80  HIS A CD2 1 
ATOM   619  C  CE1 . HIS A 1 80  ? -36.91957 10.14749  -25.89731 1.000 49.50137 ? 80  HIS A CE1 1 
ATOM   620  N  NE2 . HIS A 1 80  ? -37.46375 9.69331   -24.78290 1.000 46.23100 ? 80  HIS A NE2 1 
ATOM   621  N  N   . SER A 1 81  ? -32.86201 13.08341  -25.57737 1.000 32.91519 ? 81  SER A N   1 
ATOM   622  C  CA  . SER A 1 81  ? -32.65927 13.42142  -26.97729 1.000 41.41402 ? 81  SER A CA  1 
ATOM   623  C  C   . SER A 1 81  ? -31.41158 12.70285  -27.46701 1.000 42.27443 ? 81  SER A C   1 
ATOM   624  O  O   . SER A 1 81  ? -30.55548 12.29583  -26.67733 1.000 34.51128 ? 81  SER A O   1 
ATOM   625  C  CB  . SER A 1 81  ? -32.52873 14.93378  -27.18908 1.000 40.89017 ? 81  SER A CB  1 
ATOM   626  O  OG  . SER A 1 81  ? -31.26640 15.39986  -26.74874 1.000 38.41114 ? 81  SER A OG  1 
ATOM   627  N  N   . MET A 1 82  ? -31.31770 12.55068  -28.78254 1.000 36.51884 ? 82  MET A N   1 
ATOM   628  C  CA  . MET A 1 82  ? -30.22869 11.82174  -29.41453 1.000 33.85713 ? 82  MET A CA  1 
ATOM   629  C  C   . MET A 1 82  ? -29.34693 12.79201  -30.18577 1.000 37.90972 ? 82  MET A C   1 
ATOM   630  O  O   . MET A 1 82  ? -29.85144 13.63550  -30.93225 1.000 35.60957 ? 82  MET A O   1 
ATOM   631  C  CB  . MET A 1 82  ? -30.77065 10.74012  -30.34968 1.000 38.15621 ? 82  MET A CB  1 
ATOM   632  C  CG  . MET A 1 82  ? -29.70282 9.88190   -31.00223 1.000 38.43183 ? 82  MET A CG  1 
ATOM   633  S  SD  . MET A 1 82  ? -30.42406 8.56132   -31.99592 1.000 40.67363 ? 82  MET A SD  1 
ATOM   634  C  CE  . MET A 1 82  ? -31.37071 9.51041   -33.18103 1.000 37.47700 ? 82  MET A CE  1 
ATOM   635  N  N   . GLN A 1 83  ? -28.03466 12.67913  -29.99376 1.000 39.05146 ? 83  GLN A N   1 
ATOM   636  C  CA  . GLN A 1 83  ? -27.04832 13.42493  -30.77048 1.000 33.53020 ? 83  GLN A CA  1 
ATOM   637  C  C   . GLN A 1 83  ? -26.07283 12.42051  -31.36565 1.000 39.82865 ? 83  GLN A C   1 
ATOM   638  O  O   . GLN A 1 83  ? -25.24139 11.86105  -30.64150 1.000 34.02162 ? 83  GLN A O   1 
ATOM   639  C  CB  . GLN A 1 83  ? -26.31529 14.45561  -29.90903 1.000 37.38626 ? 83  GLN A CB  1 
ATOM   640  C  CG  . GLN A 1 83  ? -25.28852 15.26703  -30.69360 1.000 38.25569 ? 83  GLN A CG  1 
ATOM   641  C  CD  . GLN A 1 83  ? -24.48185 16.19969  -29.81721 1.000 41.74944 ? 83  GLN A CD  1 
ATOM   642  O  OE1 . GLN A 1 83  ? -24.65814 16.22812  -28.60155 1.000 38.24053 ? 83  GLN A OE1 1 
ATOM   643  N  NE2 . GLN A 1 83  ? -23.58937 16.97107  -30.43137 1.000 42.58021 ? 83  GLN A NE2 1 
ATOM   644  N  N   . ASN A 1 84  ? -26.18256 12.19328  -32.67587 1.000 32.50064 ? 84  ASN A N   1 
ATOM   645  C  CA  . ASN A 1 84  ? -25.38491 11.19674  -33.39202 1.000 29.73396 ? 84  ASN A CA  1 
ATOM   646  C  C   . ASN A 1 84  ? -25.57138 9.84918   -32.68794 1.000 32.80657 ? 84  ASN A C   1 
ATOM   647  O  O   . ASN A 1 84  ? -26.71838 9.42497   -32.50648 1.000 31.91812 ? 84  ASN A O   1 
ATOM   648  C  CB  . ASN A 1 84  ? -23.96174 11.70375  -33.50939 1.000 32.90945 ? 84  ASN A CB  1 
ATOM   649  C  CG  . ASN A 1 84  ? -23.86048 12.98339  -34.34923 1.000 32.21010 ? 84  ASN A CG  1 
ATOM   650  O  OD1 . ASN A 1 84  ? -24.46359 13.08964  -35.41512 1.000 36.85065 ? 84  ASN A OD1 1 
ATOM   651  N  ND2 . ASN A 1 84  ? -23.11113 13.96156  -33.85640 1.000 38.25290 ? 84  ASN A ND2 1 
ATOM   652  N  N   . CYS A 1 85  ? -24.50897 9.15847   -32.26978 1.000 32.37771 ? 85  CYS A N   1 
ATOM   653  C  CA  . CYS A 1 85  ? -24.66130 7.83992   -31.66244 1.000 30.79457 ? 85  CYS A CA  1 
ATOM   654  C  C   . CYS A 1 85  ? -24.69552 7.87507   -30.13863 1.000 33.23982 ? 85  CYS A C   1 
ATOM   655  O  O   . CYS A 1 85  ? -24.58760 6.82151   -29.50628 1.000 34.47535 ? 85  CYS A O   1 
ATOM   656  C  CB  . CYS A 1 85  ? -23.53729 6.91379   -32.12649 1.000 32.65989 ? 85  CYS A CB  1 
ATOM   657  S  SG  . CYS A 1 85  ? -23.49145 6.61297   -33.90112 1.000 38.95822 ? 85  CYS A SG  1 
ATOM   658  N  N   . VAL A 1 86  ? -24.82363 9.05081   -29.53518 1.000 32.02706 ? 86  VAL A N   1 
ATOM   659  C  CA  . VAL A 1 86  ? -24.85887 9.19467   -28.08461 1.000 38.38987 ? 86  VAL A CA  1 
ATOM   660  C  C   . VAL A 1 86  ? -26.26136 9.61942   -27.66734 1.000 37.69793 ? 86  VAL A C   1 
ATOM   661  O  O   . VAL A 1 86  ? -26.84294 10.53896  -28.25751 1.000 28.88760 ? 86  VAL A O   1 
ATOM   662  C  CB  . VAL A 1 86  ? -23.80065 10.19921  -27.59460 1.000 35.41130 ? 86  VAL A CB  1 
ATOM   663  C  CG1 . VAL A 1 86  ? -24.20706 10.79677  -26.25746 1.000 36.36514 ? 86  VAL A CG1 1 
ATOM   664  C  CG2 . VAL A 1 86  ? -22.44165 9.51415   -27.47880 1.000 35.07011 ? 86  VAL A CG2 1 
ATOM   665  N  N   . LEU A 1 87  ? -26.80042 8.94812   -26.65151 1.000 34.12203 ? 87  LEU A N   1 
ATOM   666  C  CA  . LEU A 1 87  ? -28.07657 9.31843   -26.05838 1.000 32.70201 ? 87  LEU A CA  1 
ATOM   667  C  C   . LEU A 1 87  ? -27.84192 10.23984  -24.86940 1.000 39.30195 ? 87  LEU A C   1 
ATOM   668  O  O   . LEU A 1 87  ? -26.91791 10.02862  -24.07977 1.000 34.89097 ? 87  LEU A O   1 
ATOM   669  C  CB  . LEU A 1 87  ? -28.84168 8.07416   -25.61255 1.000 29.72670 ? 87  LEU A CB  1 
ATOM   670  C  CG  . LEU A 1 87  ? -30.20977 8.30806   -24.97413 1.000 35.53726 ? 87  LEU A CG  1 
ATOM   671  C  CD1 . LEU A 1 87  ? -31.17577 8.89325   -25.99480 1.000 42.36607 ? 87  LEU A CD1 1 
ATOM   672  C  CD2 . LEU A 1 87  ? -30.73945 7.00978   -24.39544 1.000 36.21910 ? 87  LEU A CD2 1 
ATOM   673  N  N   . LYS A 1 88  ? -28.67829 11.26771  -24.74780 1.000 32.56020 ? 88  LYS A N   1 
ATOM   674  C  CA  . LYS A 1 88  ? -28.53377 12.27746  -23.70316 1.000 38.90485 ? 88  LYS A CA  1 
ATOM   675  C  C   . LYS A 1 88  ? -29.78768 12.27640  -22.83996 1.000 40.10910 ? 88  LYS A C   1 
ATOM   676  O  O   . LYS A 1 88  ? -30.87402 12.62154  -23.31583 1.000 38.39256 ? 88  LYS A O   1 
ATOM   677  C  CB  . LYS A 1 88  ? -28.27164 13.65611  -24.31020 1.000 31.77313 ? 88  LYS A CB  1 
ATOM   678  C  CG  . LYS A 1 88  ? -26.91746 13.75527  -24.98712 1.000 37.84076 ? 88  LYS A CG  1 
ATOM   679  C  CD  . LYS A 1 88  ? -26.52022 15.19149  -25.27924 1.000 40.04167 ? 88  LYS A CD  1 
ATOM   680  C  CE  . LYS A 1 88  ? -27.22699 15.73969  -26.50232 1.000 47.67473 ? 88  LYS A CE  1 
ATOM   681  N  NZ  . LYS A 1 88  ? -26.64090 17.04722  -26.91258 1.000 50.77593 ? 88  LYS A NZ  1 
ATOM   682  N  N   . LEU A 1 89  ? -29.63332 11.88423  -21.57570 1.000 35.43920 ? 89  LEU A N   1 
ATOM   683  C  CA  . LEU A 1 89  ? -30.74013 11.79265  -20.62977 1.000 40.06878 ? 89  LEU A CA  1 
ATOM   684  C  C   . LEU A 1 89  ? -30.71770 13.01643  -19.72137 1.000 42.82118 ? 89  LEU A C   1 
ATOM   685  O  O   . LEU A 1 89  ? -29.80816 13.17227  -18.89864 1.000 41.57983 ? 89  LEU A O   1 
ATOM   686  C  CB  . LEU A 1 89  ? -30.64981 10.50850  -19.80831 1.000 33.95788 ? 89  LEU A CB  1 
ATOM   687  C  CG  . LEU A 1 89  ? -30.72031 9.19570   -20.58764 1.000 37.33381 ? 89  LEU A CG  1 
ATOM   688  C  CD1 . LEU A 1 89  ? -30.58310 8.00980   -19.65157 1.000 31.89899 ? 89  LEU A CD1 1 
ATOM   689  C  CD2 . LEU A 1 89  ? -32.01743 9.11003   -21.37260 1.000 45.25823 ? 89  LEU A CD2 1 
ATOM   690  N  N   . LYS A 1 90  ? -31.71934 13.87925  -19.86674 1.000 46.24978 ? 90  LYS A N   1 
ATOM   691  C  CA  . LYS A 1 90  ? -31.86434 15.02157  -18.97747 1.000 45.99708 ? 90  LYS A CA  1 
ATOM   692  C  C   . LYS A 1 90  ? -32.45356 14.55311  -17.65297 1.000 41.93978 ? 90  LYS A C   1 
ATOM   693  O  O   . LYS A 1 90  ? -33.47008 13.85144  -17.63032 1.000 43.52690 ? 90  LYS A O   1 
ATOM   694  C  CB  . LYS A 1 90  ? -32.75211 16.08674  -19.61962 1.000 46.33594 ? 90  LYS A CB  1 
ATOM   695  C  CG  . LYS A 1 90  ? -32.55240 17.48561  -19.06353 1.000 50.26490 ? 90  LYS A CG  1 
ATOM   696  C  CD  . LYS A 1 90  ? -33.17600 18.53458  -19.97500 1.000 64.30012 ? 90  LYS A CD  1 
ATOM   697  C  CE  . LYS A 1 90  ? -34.68715 18.38002  -20.05800 1.000 66.75531 ? 90  LYS A CE  1 
ATOM   698  N  NZ  . LYS A 1 90  ? -35.28713 19.30652  -21.06185 1.000 63.48452 ? 90  LYS A NZ  1 
ATOM   699  N  N   . VAL A 1 91  ? -31.80374 14.92339  -16.55112 1.000 41.42523 ? 91  VAL A N   1 
ATOM   700  C  CA  . VAL A 1 91  ? -32.24515 14.53189  -15.22023 1.000 43.99278 ? 91  VAL A CA  1 
ATOM   701  C  C   . VAL A 1 91  ? -32.57428 15.78562  -14.42037 1.000 46.26514 ? 91  VAL A C   1 
ATOM   702  O  O   . VAL A 1 91  ? -32.17258 16.89930  -14.76715 1.000 46.08670 ? 91  VAL A O   1 
ATOM   703  C  CB  . VAL A 1 91  ? -31.19613 13.67142  -14.48537 1.000 49.00319 ? 91  VAL A CB  1 
ATOM   704  C  CG1 . VAL A 1 91  ? -31.21344 12.24485  -15.01728 1.000 44.47214 ? 91  VAL A CG1 1 
ATOM   705  C  CG2 . VAL A 1 91  ? -29.80987 14.28093  -14.63147 1.000 41.46686 ? 91  VAL A CG2 1 
ATOM   706  N  N   . ASP A 1 92  ? -33.31935 15.58956  -13.33259 1.000 46.57422 ? 92  ASP A N   1 
ATOM   707  C  CA  . ASP A 1 92  ? -33.78886 16.69556  -12.50621 1.000 53.93604 ? 92  ASP A CA  1 
ATOM   708  C  C   . ASP A 1 92  ? -32.77238 17.14041  -11.46189 1.000 51.63382 ? 92  ASP A C   1 
ATOM   709  O  O   . ASP A 1 92  ? -33.08866 18.00695  -10.64089 1.000 53.06273 ? 92  ASP A O   1 
ATOM   710  C  CB  . ASP A 1 92  ? -35.11141 16.32651  -11.81839 1.000 46.93056 ? 92  ASP A CB  1 
ATOM   711  C  CG  . ASP A 1 92  ? -34.96501 15.19607  -10.81044 1.000 56.00455 ? 92  ASP A CG  1 
ATOM   712  O  OD1 . ASP A 1 92  ? -33.87104 14.59975  -10.70966 1.000 54.47447 ? 92  ASP A OD1 1 
ATOM   713  O  OD2 . ASP A 1 92  ? -35.95940 14.90411  -10.11127 1.000 61.28062 ? 92  ASP A OD2 1 
ATOM   714  N  N   . THR A 1 93  ? -31.56792 16.57602  -11.46909 1.000 55.83663 ? 93  THR A N   1 
ATOM   715  C  CA  . THR A 1 93  ? -30.52436 16.95400  -10.52715 1.000 39.95196 ? 93  THR A CA  1 
ATOM   716  C  C   . THR A 1 93  ? -29.21471 17.11338  -11.27928 1.000 43.96622 ? 93  THR A C   1 
ATOM   717  O  O   . THR A 1 93  ? -28.83712 16.23776  -12.06258 1.000 44.66058 ? 93  THR A O   1 
ATOM   718  C  CB  . THR A 1 93  ? -30.36236 15.91091  -9.41636  1.000 40.81208 ? 93  THR A CB  1 
ATOM   719  O  OG1 . THR A 1 93  ? -31.63884 15.62099  -8.83338  1.000 45.91944 ? 93  THR A OG1 1 
ATOM   720  C  CG2 . THR A 1 93  ? -29.42608 16.43106  -8.33721  1.000 47.01103 ? 93  THR A CG2 1 
ATOM   721  N  N   . ALA A 1 94  ? -28.53406 18.23079  -11.05016 1.000 42.85182 ? 94  ALA A N   1 
ATOM   722  C  CA  . ALA A 1 94  ? -27.19350 18.41834  -11.57796 1.000 42.46756 ? 94  ALA A CA  1 
ATOM   723  C  C   . ALA A 1 94  ? -26.19042 17.67681  -10.70567 1.000 49.63558 ? 94  ALA A C   1 
ATOM   724  O  O   . ALA A 1 94  ? -26.32909 17.62992  -9.48068  1.000 44.50484 ? 94  ALA A O   1 
ATOM   725  C  CB  . ALA A 1 94  ? -26.84045 19.90264  -11.63600 1.000 39.30511 ? 94  ALA A CB  1 
ATOM   726  N  N   . ASN A 1 95  ? -25.18714 17.08986  -11.33846 1.000 50.36268 ? 95  ASN A N   1 
ATOM   727  C  CA  . ASN A 1 95  ? -24.16108 16.36772  -10.59483 1.000 43.63162 ? 95  ASN A CA  1 
ATOM   728  C  C   . ASN A 1 95  ? -23.32200 17.35332  -9.79246  1.000 42.48876 ? 95  ASN A C   1 
ATOM   729  O  O   . ASN A 1 95  ? -22.62224 18.18207  -10.39257 1.000 42.08898 ? 95  ASN A O   1 
ATOM   730  C  CB  . ASN A 1 95  ? -23.27580 15.56784  -11.54649 1.000 50.34101 ? 95  ASN A CB  1 
ATOM   731  C  CG  . ASN A 1 95  ? -22.32486 14.63094  -10.81732 1.000 44.85521 ? 95  ASN A CG  1 
ATOM   732  O  OD1 . ASN A 1 95  ? -22.20283 14.67491  -9.59288  1.000 42.40498 ? 95  ASN A OD1 1 
ATOM   733  N  ND2 . ASN A 1 95  ? -21.64107 13.77992  -11.57325 1.000 40.65805 ? 95  ASN A ND2 1 
ATOM   734  N  N   . PRO A 1 96  ? -23.34948 17.30661  -8.45720  1.000 40.48583 ? 96  PRO A N   1 
ATOM   735  C  CA  . PRO A 1 96  ? -22.52521 18.24257  -7.67798  1.000 41.10433 ? 96  PRO A CA  1 
ATOM   736  C  C   . PRO A 1 96  ? -21.03339 18.01593  -7.84439  1.000 43.42730 ? 96  PRO A C   1 
ATOM   737  O  O   . PRO A 1 96  ? -20.25052 18.93637  -7.57909  1.000 40.98281 ? 96  PRO A O   1 
ATOM   738  C  CB  . PRO A 1 96  ? -22.97541 17.98688  -6.23410  1.000 46.85189 ? 96  PRO A CB  1 
ATOM   739  C  CG  . PRO A 1 96  ? -23.47951 16.57640  -6.24762  1.000 44.86936 ? 96  PRO A CG  1 
ATOM   740  C  CD  . PRO A 1 96  ? -24.11078 16.38437  -7.59610  1.000 38.06090 ? 96  PRO A CD  1 
ATOM   741  N  N   . LYS A 1 97  ? -20.61572 16.83078  -8.28593  1.000 41.34696 ? 97  LYS A N   1 
ATOM   742  C  CA  . LYS A 1 97  ? -19.21105 16.52388  -8.50459  1.000 41.68227 ? 97  LYS A CA  1 
ATOM   743  C  C   . LYS A 1 97  ? -18.75458 16.83314  -9.92551  1.000 48.46331 ? 97  LYS A C   1 
ATOM   744  O  O   . LYS A 1 97  ? -17.68741 16.36377  -10.33629 1.000 46.31418 ? 97  LYS A O   1 
ATOM   745  C  CB  . LYS A 1 97  ? -18.93628 15.05364  -8.18531  1.000 46.91440 ? 97  LYS A CB  1 
ATOM   746  C  CG  . LYS A 1 97  ? -19.23218 14.65552  -6.75467  1.000 45.53159 ? 97  LYS A CG  1 
ATOM   747  C  CD  . LYS A 1 97  ? -19.13688 13.14868  -6.59064  1.000 47.73768 ? 97  LYS A CD  1 
ATOM   748  C  CE  . LYS A 1 97  ? -19.51451 12.72182  -5.18466  1.000 51.23456 ? 97  LYS A CE  1 
ATOM   749  N  NZ  . LYS A 1 97  ? -19.77188 11.25642  -5.10570  1.000 64.24809 ? 97  LYS A NZ  1 
ATOM   750  N  N   . THR A 1 98  ? -19.53506 17.60307  -10.68319 1.000 43.57256 ? 98  THR A N   1 
ATOM   751  C  CA  . THR A 1 98  ? -19.17720 17.92698  -12.05761 1.000 40.52844 ? 98  THR A CA  1 
ATOM   752  C  C   . THR A 1 98  ? -17.90078 18.75373  -12.08375 1.000 44.84026 ? 98  THR A C   1 
ATOM   753  O  O   . THR A 1 98  ? -17.88530 19.88673  -11.58843 1.000 52.73915 ? 98  THR A O   1 
ATOM   754  C  CB  . THR A 1 98  ? -20.30349 18.69014  -12.75631 1.000 40.71383 ? 98  THR A CB  1 
ATOM   755  O  OG1 . THR A 1 98  ? -21.49911 17.89929  -12.74931 1.000 42.82159 ? 98  THR A OG1 1 
ATOM   756  C  CG2 . THR A 1 98  ? -19.91563 19.00406  -14.19419 1.000 35.25300 ? 98  THR A CG2 1 
ATOM   757  N  N   . PRO A 1 99  ? -16.82101 18.23434  -12.64638 1.000 44.22091 ? 99  PRO A N   1 
ATOM   758  C  CA  . PRO A 1 99  ? -15.57648 18.99918  -12.72648 1.000 37.92539 ? 99  PRO A CA  1 
ATOM   759  C  C   . PRO A 1 99  ? -15.66971 20.03383  -13.84133 1.000 38.79697 ? 99  PRO A C   1 
ATOM   760  O  O   . PRO A 1 99  ? -16.64998 20.10172  -14.57774 1.000 43.54864 ? 99  PRO A O   1 
ATOM   761  C  CB  . PRO A 1 99  ? -14.53639 17.92448  -13.04392 1.000 41.11379 ? 99  PRO A CB  1 
ATOM   762  C  CG  . PRO A 1 99  ? -15.30192 16.93341  -13.87396 1.000 37.03525 ? 99  PRO A CG  1 
ATOM   763  C  CD  . PRO A 1 99  ? -16.70682 16.92305  -13.31340 1.000 40.93790 ? 99  PRO A CD  1 
ATOM   764  N  N   . LYS A 1 100 ? -14.62976 20.85483  -13.94731 1.000 40.04445 ? 100 LYS A N   1 
ATOM   765  C  CA  . LYS A 1 100 ? -14.45083 21.65018  -15.15192 1.000 35.96456 ? 100 LYS A CA  1 
ATOM   766  C  C   . LYS A 1 100 ? -14.12721 20.71224  -16.30548 1.000 40.93839 ? 100 LYS A C   1 
ATOM   767  O  O   . LYS A 1 100 ? -13.20780 19.89380  -16.20968 1.000 42.30757 ? 100 LYS A O   1 
ATOM   768  C  CB  . LYS A 1 100 ? -13.33632 22.67535  -14.96156 1.000 32.14589 ? 100 LYS A CB  1 
ATOM   769  N  N   . TYR A 1 101 ? -14.89227 20.80858  -17.38965 1.000 43.06521 ? 101 TYR A N   1 
ATOM   770  C  CA  . TYR A 1 101 ? -14.75792 19.83826  -18.46425 1.000 42.93761 ? 101 TYR A CA  1 
ATOM   771  C  C   . TYR A 1 101 ? -15.01892 20.49722  -19.80932 1.000 43.30135 ? 101 TYR A C   1 
ATOM   772  O  O   . TYR A 1 101 ? -15.48714 21.63452  -19.89516 1.000 53.92623 ? 101 TYR A O   1 
ATOM   773  C  CB  . TYR A 1 101 ? -15.70543 18.64836  -18.26359 1.000 40.30249 ? 101 TYR A CB  1 
ATOM   774  C  CG  . TYR A 1 101 ? -17.16028 18.96424  -18.53774 1.000 41.09286 ? 101 TYR A CG  1 
ATOM   775  C  CD1 . TYR A 1 101 ? -17.96877 19.51813  -17.55410 1.000 43.46405 ? 101 TYR A CD1 1 
ATOM   776  C  CD2 . TYR A 1 101 ? -17.72695 18.70065  -19.77921 1.000 40.42917 ? 101 TYR A CD2 1 
ATOM   777  C  CE1 . TYR A 1 101 ? -19.29869 19.80659  -17.80072 1.000 51.83851 ? 101 TYR A CE1 1 
ATOM   778  C  CE2 . TYR A 1 101 ? -19.05505 18.98830  -20.03568 1.000 44.79231 ? 101 TYR A CE2 1 
ATOM   779  C  CZ  . TYR A 1 101 ? -19.83605 19.53971  -19.04291 1.000 42.11292 ? 101 TYR A CZ  1 
ATOM   780  O  OH  . TYR A 1 101 ? -21.15846 19.82409  -19.29015 1.000 46.57565 ? 101 TYR A OH  1 
ATOM   781  N  N   . LYS A 1 102 ? -14.69793 19.75115  -20.86345 1.000 47.73849 ? 102 LYS A N   1 
ATOM   782  C  CA  . LYS A 1 102 ? -15.06358 20.08801  -22.23100 1.000 43.08739 ? 102 LYS A CA  1 
ATOM   783  C  C   . LYS A 1 102 ? -14.90507 18.83392  -23.07749 1.000 43.45153 ? 102 LYS A C   1 
ATOM   784  O  O   . LYS A 1 102 ? -14.17603 17.90807  -22.71391 1.000 40.95219 ? 102 LYS A O   1 
ATOM   785  C  CB  . LYS A 1 102 ? -14.22077 21.24322  -22.78758 1.000 46.23993 ? 102 LYS A CB  1 
ATOM   786  C  CG  . LYS A 1 102 ? -12.72127 20.99697  -22.82521 1.000 48.60907 ? 102 LYS A CG  1 
ATOM   787  C  CD  . LYS A 1 102 ? -11.99029 22.25951  -23.27076 1.000 59.22165 ? 102 LYS A CD  1 
ATOM   788  C  CE  . LYS A 1 102 ? -10.47987 22.12709  -23.14695 1.000 57.15275 ? 102 LYS A CE  1 
ATOM   789  N  NZ  . LYS A 1 102 ? -9.89735  21.22665  -24.17906 1.000 61.32860 ? 102 LYS A NZ  1 
ATOM   790  N  N   . PHE A 1 103 ? -15.61359 18.80592  -24.20155 1.000 43.82965 ? 103 PHE A N   1 
ATOM   791  C  CA  . PHE A 1 103 ? -15.57668 17.67682  -25.12148 1.000 41.49582 ? 103 PHE A CA  1 
ATOM   792  C  C   . PHE A 1 103 ? -14.59581 17.97600  -26.24618 1.000 38.59432 ? 103 PHE A C   1 
ATOM   793  O  O   . PHE A 1 103 ? -14.60538 19.07762  -26.80429 1.000 44.40805 ? 103 PHE A O   1 
ATOM   794  C  CB  . PHE A 1 103 ? -16.96619 17.38924  -25.69500 1.000 34.97607 ? 103 PHE A CB  1 
ATOM   795  C  CG  . PHE A 1 103 ? -17.98008 16.97644  -24.66322 1.000 38.47827 ? 103 PHE A CG  1 
ATOM   796  C  CD1 . PHE A 1 103 ? -17.58068 16.47558  -23.43477 1.000 33.80585 ? 103 PHE A CD1 1 
ATOM   797  C  CD2 . PHE A 1 103 ? -19.33783 17.08283  -24.92787 1.000 36.33120 ? 103 PHE A CD2 1 
ATOM   798  C  CE1 . PHE A 1 103 ? -18.51619 16.09287  -22.48859 1.000 27.71190 ? 103 PHE A CE1 1 
ATOM   799  C  CE2 . PHE A 1 103 ? -20.27268 16.70251  -23.98860 1.000 30.46139 ? 103 PHE A CE2 1 
ATOM   800  C  CZ  . PHE A 1 103 ? -19.86228 16.20812  -22.76684 1.000 31.27381 ? 103 PHE A CZ  1 
ATOM   801  N  N   . VAL A 1 104 ? -13.74502 17.00258  -26.56940 1.000 36.02523 ? 104 VAL A N   1 
ATOM   802  C  CA  . VAL A 1 104 ? -12.77512 17.14537  -27.64728 1.000 36.12984 ? 104 VAL A CA  1 
ATOM   803  C  C   . VAL A 1 104 ? -12.78336 15.88339  -28.49809 1.000 36.74725 ? 104 VAL A C   1 
ATOM   804  O  O   . VAL A 1 104 ? -13.06918 14.78316  -28.01622 1.000 40.35877 ? 104 VAL A O   1 
ATOM   805  C  CB  . VAL A 1 104 ? -11.34576 17.42870  -27.12413 1.000 41.77408 ? 104 VAL A CB  1 
ATOM   806  C  CG1 . VAL A 1 104 ? -11.31620 18.69695  -26.27655 1.000 43.32710 ? 104 VAL A CG1 1 
ATOM   807  C  CG2 . VAL A 1 104 ? -10.81537 16.24030  -26.34101 1.000 47.35195 ? 104 VAL A CG2 1 
ATOM   808  N  N   . ARG A 1 105 ? -12.48093 16.05365  -29.78013 1.000 31.21771 ? 105 ARG A N   1 
ATOM   809  C  CA  . ARG A 1 105 ? -12.24419 14.94010  -30.68794 1.000 34.93179 ? 105 ARG A CA  1 
ATOM   810  C  C   . ARG A 1 105 ? -10.74983 14.87944  -30.97084 1.000 32.24259 ? 105 ARG A C   1 
ATOM   811  O  O   . ARG A 1 105 ? -10.16106 15.87224  -31.40827 1.000 38.51482 ? 105 ARG A O   1 
ATOM   812  C  CB  . ARG A 1 105 ? -13.04257 15.10166  -31.98237 1.000 32.41000 ? 105 ARG A CB  1 
ATOM   813  C  CG  . ARG A 1 105 ? -12.88572 13.94602  -32.96044 1.000 31.66646 ? 105 ARG A CG  1 
ATOM   814  C  CD  . ARG A 1 105 ? -13.83002 14.09132  -34.14257 1.000 35.26146 ? 105 ARG A CD  1 
ATOM   815  N  NE  . ARG A 1 105 ? -13.77541 12.93987  -35.03614 1.000 37.42147 ? 105 ARG A NE  1 
ATOM   816  C  CZ  . ARG A 1 105 ? -14.50675 11.84312  -34.88961 1.000 31.09330 ? 105 ARG A CZ  1 
ATOM   817  N  NH1 . ARG A 1 105 ? -15.35208 11.70534  -33.88048 1.000 32.47430 ? 105 ARG A NH1 1 
ATOM   818  N  NH2 . ARG A 1 105 ? -14.38652 10.85956  -35.77669 1.000 32.19086 ? 105 ARG A NH2 1 
ATOM   819  N  N   . ILE A 1 106 ? -10.13963 13.73152  -30.70821 1.000 33.76862 ? 106 ILE A N   1 
ATOM   820  C  CA  . ILE A 1 106 ? -8.70787  13.57134  -30.85922 1.000 32.17910 ? 106 ILE A CA  1 
ATOM   821  C  C   . ILE A 1 106 ? -8.40027  12.98026  -32.22930 1.000 34.47735 ? 106 ILE A C   1 
ATOM   822  O  O   . ILE A 1 106 ? -9.28728  12.54180  -32.95800 1.000 34.09688 ? 106 ILE A O   1 
ATOM   823  C  CB  . ILE A 1 106 ? -8.10223  12.70166  -29.73261 1.000 35.40013 ? 106 ILE A CB  1 
ATOM   824  C  CG1 . ILE A 1 106 ? -8.73540  11.30851  -29.73688 1.000 35.73918 ? 106 ILE A CG1 1 
ATOM   825  C  CG2 . ILE A 1 106 ? -8.28557  13.37707  -28.38384 1.000 32.30604 ? 106 ILE A CG2 1 
ATOM   826  C  CD1 . ILE A 1 106 ? -8.13897  10.36806  -28.71383 1.000 36.51012 ? 106 ILE A CD1 1 
ATOM   827  N  N   . GLN A 1 107 ? -7.12204  12.96691  -32.58492 1.000 35.36574 ? 107 GLN A N   1 
ATOM   828  C  CA  . GLN A 1 107 ? -6.61738  12.40042  -33.82295 1.000 39.03220 ? 107 GLN A CA  1 
ATOM   829  C  C   . GLN A 1 107 ? -5.79622  11.15012  -33.53601 1.000 32.69964 ? 107 GLN A C   1 
ATOM   830  O  O   . GLN A 1 107 ? -5.34505  10.94028  -32.40444 1.000 34.62447 ? 107 GLN A O   1 
ATOM   831  C  CB  . GLN A 1 107 ? -5.75622  13.43027  -34.56889 1.000 32.64766 ? 107 GLN A CB  1 
ATOM   832  C  CG  . GLN A 1 107 ? -6.48843  14.72992  -34.86958 1.000 39.88041 ? 107 GLN A CG  1 
ATOM   833  C  CD  . GLN A 1 107 ? -7.78267  14.50659  -35.62922 1.000 44.23329 ? 107 GLN A CD  1 
ATOM   834  O  OE1 . GLN A 1 107 ? -7.84253  13.69213  -36.55078 1.000 47.82181 ? 107 GLN A OE1 1 
ATOM   835  N  NE2 . GLN A 1 107 ? -8.83036  15.22546  -35.23940 1.000 50.36517 ? 107 GLN A NE2 1 
ATOM   836  N  N   . PRO A 1 108 ? -5.60802  10.27886  -34.52818 1.000 32.63210 ? 108 PRO A N   1 
ATOM   837  C  CA  . PRO A 1 108 ? -4.75373  9.10224   -34.32566 1.000 34.32049 ? 108 PRO A CA  1 
ATOM   838  C  C   . PRO A 1 108 ? -3.38022  9.48578   -33.78983 1.000 31.98859 ? 108 PRO A C   1 
ATOM   839  O  O   . PRO A 1 108 ? -2.82675  10.53221  -34.13181 1.000 32.58361 ? 108 PRO A O   1 
ATOM   840  C  CB  . PRO A 1 108 ? -4.66431  8.48923   -35.72623 1.000 30.70194 ? 108 PRO A CB  1 
ATOM   841  C  CG  . PRO A 1 108 ? -5.95219  8.87884   -36.36911 1.000 37.96995 ? 108 PRO A CG  1 
ATOM   842  C  CD  . PRO A 1 108 ? -6.27838  10.25155  -35.84186 1.000 30.60627 ? 108 PRO A CD  1 
ATOM   843  N  N   . GLY A 1 109 ? -2.83554  8.62555   -32.93016 1.000 31.35299 ? 109 GLY A N   1 
ATOM   844  C  CA  . GLY A 1 109 ? -1.60232  8.90247   -32.23082 1.000 28.73520 ? 109 GLY A CA  1 
ATOM   845  C  C   . GLY A 1 109 ? -1.76909  9.62915   -30.91285 1.000 33.06142 ? 109 GLY A C   1 
ATOM   846  O  O   . GLY A 1 109 ? -0.83976  9.62427   -30.09627 1.000 26.75027 ? 109 GLY A O   1 
ATOM   847  N  N   . GLN A 1 110 ? -2.92286  10.25186  -30.68147 1.000 31.05674 ? 110 GLN A N   1 
ATOM   848  C  CA  . GLN A 1 110 ? -3.16037  10.94946  -29.42612 1.000 28.39095 ? 110 GLN A CA  1 
ATOM   849  C  C   . GLN A 1 110 ? -3.43288  9.94672   -28.31107 1.000 32.52683 ? 110 GLN A C   1 
ATOM   850  O  O   . GLN A 1 110 ? -4.04044  8.89582   -28.53384 1.000 32.64879 ? 110 GLN A O   1 
ATOM   851  C  CB  . GLN A 1 110 ? -4.33739  11.91368  -29.57237 1.000 31.84613 ? 110 GLN A CB  1 
ATOM   852  C  CG  . GLN A 1 110 ? -4.60666  12.77511  -28.35316 1.000 32.41321 ? 110 GLN A CG  1 
ATOM   853  C  CD  . GLN A 1 110 ? -3.45378  13.71037  -28.03728 1.000 41.94828 ? 110 GLN A CD  1 
ATOM   854  O  OE1 . GLN A 1 110 ? -2.59768  13.40378  -27.20816 1.000 39.04833 ? 110 GLN A OE1 1 
ATOM   855  N  NE2 . GLN A 1 110 ? -3.42773  14.86027  -28.70167 1.000 45.83532 ? 110 GLN A NE2 1 
ATOM   856  N  N   . THR A 1 111 ? -2.98022  10.27558  -27.10526 1.000 30.08771 ? 111 THR A N   1 
ATOM   857  C  CA  . THR A 1 111 ? -3.11845  9.40638   -25.94835 1.000 26.07589 ? 111 THR A CA  1 
ATOM   858  C  C   . THR A 1 111 ? -4.14260  9.96504   -24.97020 1.000 31.33789 ? 111 THR A C   1 
ATOM   859  O  O   . THR A 1 111 ? -4.42988  11.16614  -24.94652 1.000 31.55290 ? 111 THR A O   1 
ATOM   860  C  CB  . THR A 1 111 ? -1.77674  9.22474   -25.23574 1.000 31.38191 ? 111 THR A CB  1 
ATOM   861  O  OG1 . THR A 1 111 ? -1.23108  10.51043  -24.91870 1.000 31.40831 ? 111 THR A OG1 1 
ATOM   862  C  CG2 . THR A 1 111 ? -0.80694  8.46575   -26.12489 1.000 29.67515 ? 111 THR A CG2 1 
ATOM   863  N  N   . PHE A 1 112 ? -4.68728  9.06500   -24.15613 1.000 26.45980 ? 112 PHE A N   1 
ATOM   864  C  CA  . PHE A 1 112 ? -5.65634  9.42445   -23.13086 1.000 31.64884 ? 112 PHE A CA  1 
ATOM   865  C  C   . PHE A 1 112 ? -5.78216  8.25501   -22.16525 1.000 31.50559 ? 112 PHE A C   1 
ATOM   866  O  O   . PHE A 1 112 ? -5.30383  7.14946   -22.43113 1.000 26.90121 ? 112 PHE A O   1 
ATOM   867  C  CB  . PHE A 1 112 ? -7.01620  9.78618   -23.74220 1.000 28.80224 ? 112 PHE A CB  1 
ATOM   868  C  CG  . PHE A 1 112 ? -7.62413  8.68452   -24.56965 1.000 26.69547 ? 112 PHE A CG  1 
ATOM   869  C  CD1 . PHE A 1 112 ? -7.23036  8.48484   -25.88546 1.000 35.11235 ? 112 PHE A CD1 1 
ATOM   870  C  CD2 . PHE A 1 112 ? -8.59151  7.85368   -24.03548 1.000 24.99156 ? 112 PHE A CD2 1 
ATOM   871  C  CE1 . PHE A 1 112 ? -7.79113  7.47511   -26.64927 1.000 32.87845 ? 112 PHE A CE1 1 
ATOM   872  C  CE2 . PHE A 1 112 ? -9.15943  6.84147   -24.79527 1.000 33.37364 ? 112 PHE A CE2 1 
ATOM   873  C  CZ  . PHE A 1 112 ? -8.75729  6.65303   -26.10373 1.000 32.79620 ? 112 PHE A CZ  1 
ATOM   874  N  N   . SER A 1 113 ? -6.43831  8.51434   -21.03889 1.000 23.29940 ? 113 SER A N   1 
ATOM   875  C  CA  . SER A 1 113 ? -6.67273  7.50704   -20.01689 1.000 32.16666 ? 113 SER A CA  1 
ATOM   876  C  C   . SER A 1 113 ? -8.10438  6.99889   -20.11158 1.000 29.32050 ? 113 SER A C   1 
ATOM   877  O  O   . SER A 1 113 ? -9.02505  7.74716   -20.44513 1.000 31.08032 ? 113 SER A O   1 
ATOM   878  C  CB  . SER A 1 113 ? -6.41120  8.07410   -18.61834 1.000 27.93448 ? 113 SER A CB  1 
ATOM   879  O  OG  . SER A 1 113 ? -5.15610  8.72968   -18.55671 1.000 34.45065 ? 113 SER A OG  1 
ATOM   880  N  N   . VAL A 1 114 ? -8.28477  5.71673   -19.81069 1.000 27.21828 ? 114 VAL A N   1 
ATOM   881  C  CA  . VAL A 1 114 ? -9.58838  5.06656   -19.85768 1.000 30.80289 ? 114 VAL A CA  1 
ATOM   882  C  C   . VAL A 1 114 ? -9.96785  4.64607   -18.44649 1.000 30.92493 ? 114 VAL A C   1 
ATOM   883  O  O   . VAL A 1 114 ? -9.17863  3.99533   -17.75250 1.000 27.45882 ? 114 VAL A O   1 
ATOM   884  C  CB  . VAL A 1 114 ? -9.58464  3.85602   -20.80775 1.000 33.93073 ? 114 VAL A CB  1 
ATOM   885  C  CG1 . VAL A 1 114 ? -10.85869 3.03549   -20.62799 1.000 29.55385 ? 114 VAL A CG1 1 
ATOM   886  C  CG2 . VAL A 1 114 ? -9.44656  4.31431   -22.24638 1.000 27.52584 ? 114 VAL A CG2 1 
ATOM   887  N  N   . LEU A 1 115 ? -11.16891 5.02643   -18.01965 1.000 37.98114 ? 115 LEU A N   1 
ATOM   888  C  CA  . LEU A 1 115 ? -11.73082 4.57568   -16.74850 1.000 30.84612 ? 115 LEU A CA  1 
ATOM   889  C  C   . LEU A 1 115 ? -12.73505 3.47198   -17.06378 1.000 31.66766 ? 115 LEU A C   1 
ATOM   890  O  O   . LEU A 1 115 ? -13.89609 3.73341   -17.37802 1.000 27.17398 ? 115 LEU A O   1 
ATOM   891  C  CB  . LEU A 1 115 ? -12.37622 5.72939   -15.99034 1.000 27.81419 ? 115 LEU A CB  1 
ATOM   892  C  CG  . LEU A 1 115 ? -12.93106 5.35551   -14.61392 1.000 31.52363 ? 115 LEU A CG  1 
ATOM   893  C  CD1 . LEU A 1 115 ? -11.81426 4.85195   -13.70055 1.000 28.65739 ? 115 LEU A CD1 1 
ATOM   894  C  CD2 . LEU A 1 115 ? -13.67098 6.52481   -13.97724 1.000 28.11119 ? 115 LEU A CD2 1 
ATOM   895  N  N   . ALA A 1 116 ? -12.27504 2.22613   -16.98483 1.000 28.08944 ? 116 ALA A N   1 
ATOM   896  C  CA  . ALA A 1 116 ? -13.14942 1.08737   -17.22934 1.000 36.96594 ? 116 ALA A CA  1 
ATOM   897  C  C   . ALA A 1 116 ? -14.17453 0.96684   -16.10843 1.000 31.34583 ? 116 ALA A C   1 
ATOM   898  O  O   . ALA A 1 116 ? -13.81589 0.92292   -14.92714 1.000 33.15071 ? 116 ALA A O   1 
ATOM   899  C  CB  . ALA A 1 116 ? -12.32928 -0.19738  -17.34370 1.000 27.16372 ? 116 ALA A CB  1 
ATOM   900  N  N   . CYS A 1 117 ? -15.45231 0.91172   -16.47838 1.000 28.86760 ? 117 CYS A N   1 
ATOM   901  C  CA  . CYS A 1 117 ? -16.54131 0.89892   -15.51226 1.000 33.44453 ? 117 CYS A CA  1 
ATOM   902  C  C   . CYS A 1 117 ? -17.50526 -0.23763  -15.81447 1.000 31.22197 ? 117 CYS A C   1 
ATOM   903  O  O   . CYS A 1 117 ? -17.69946 -0.62222  -16.97157 1.000 30.28572 ? 117 CYS A O   1 
ATOM   904  C  CB  . CYS A 1 117 ? -17.30850 2.22536   -15.50821 1.000 36.44453 ? 117 CYS A CB  1 
ATOM   905  S  SG  . CYS A 1 117 ? -16.34632 3.62563   -14.92285 1.000 42.45961 ? 117 CYS A SG  1 
ATOM   906  N  N   . TYR A 1 118 ? -18.11442 -0.76642  -14.75497 1.000 31.00830 ? 118 TYR A N   1 
ATOM   907  C  CA  . TYR A 1 118 ? -19.11391 -1.81902  -14.87181 1.000 33.01857 ? 118 TYR A CA  1 
ATOM   908  C  C   . TYR A 1 118 ? -20.22648 -1.54402  -13.87246 1.000 36.11079 ? 118 TYR A C   1 
ATOM   909  O  O   . TYR A 1 118 ? -19.96154 -1.36664  -12.67882 1.000 33.82341 ? 118 TYR A O   1 
ATOM   910  C  CB  . TYR A 1 118 ? -18.49746 -3.20130  -14.63356 1.000 28.14359 ? 118 TYR A CB  1 
ATOM   911  C  CG  . TYR A 1 118 ? -17.42216 -3.55039  -15.63830 1.000 35.10836 ? 118 TYR A CG  1 
ATOM   912  C  CD1 . TYR A 1 118 ? -17.74160 -4.16367  -16.84275 1.000 31.43022 ? 118 TYR A CD1 1 
ATOM   913  C  CD2 . TYR A 1 118 ? -16.08792 -3.25115  -15.38946 1.000 34.82215 ? 118 TYR A CD2 1 
ATOM   914  C  CE1 . TYR A 1 118 ? -16.76403 -4.47688  -17.76706 1.000 33.85340 ? 118 TYR A CE1 1 
ATOM   915  C  CE2 . TYR A 1 118 ? -15.10320 -3.55898  -16.30953 1.000 32.63726 ? 118 TYR A CE2 1 
ATOM   916  C  CZ  . TYR A 1 118 ? -15.44687 -4.17095  -17.49696 1.000 31.99979 ? 118 TYR A CZ  1 
ATOM   917  O  OH  . TYR A 1 118 ? -14.47085 -4.47930  -18.41582 1.000 33.75612 ? 118 TYR A OH  1 
ATOM   918  N  N   . ASN A 1 119 ? -21.46581 -1.49913  -14.36965 1.000 36.64609 ? 119 ASN A N   1 
ATOM   919  C  CA  . ASN A 1 119 ? -22.64085 -1.17139  -13.55657 1.000 35.55688 ? 119 ASN A CA  1 
ATOM   920  C  C   . ASN A 1 119 ? -22.50953 0.21696   -12.93243 1.000 37.33298 ? 119 ASN A C   1 
ATOM   921  O  O   . ASN A 1 119 ? -22.95185 0.45691   -11.80674 1.000 33.41176 ? 119 ASN A O   1 
ATOM   922  C  CB  . ASN A 1 119 ? -22.88882 -2.23056  -12.47829 1.000 35.48354 ? 119 ASN A CB  1 
ATOM   923  C  CG  . ASN A 1 119 ? -22.89610 -3.63862  -13.03420 1.000 39.80889 ? 119 ASN A CG  1 
ATOM   924  O  OD1 . ASN A 1 119 ? -23.77462 -4.00724  -13.81215 1.000 41.06262 ? 119 ASN A OD1 1 
ATOM   925  N  ND2 . ASN A 1 119 ? -21.91765 -4.43958  -12.62724 1.000 46.44245 ? 119 ASN A ND2 1 
ATOM   926  N  N   . GLY A 1 120 ? -21.89757 1.14060   -13.67311 1.000 35.87066 ? 120 GLY A N   1 
ATOM   927  C  CA  . GLY A 1 120 ? -21.65378 2.47637   -13.16846 1.000 28.76702 ? 120 GLY A CA  1 
ATOM   928  C  C   . GLY A 1 120 ? -20.57273 2.57374   -12.11900 1.000 33.84077 ? 120 GLY A C   1 
ATOM   929  O  O   . GLY A 1 120 ? -20.38757 3.64762   -11.53812 1.000 39.40442 ? 120 GLY A O   1 
ATOM   930  N  N   . SER A 1 121 ? -19.84525 1.48813   -11.86349 1.000 31.28297 ? 121 SER A N   1 
ATOM   931  C  CA  . SER A 1 121 ? -18.84878 1.44482   -10.80538 1.000 36.41794 ? 121 SER A CA  1 
ATOM   932  C  C   . SER A 1 121 ? -17.45414 1.38106   -11.40850 1.000 36.12431 ? 121 SER A C   1 
ATOM   933  O  O   . SER A 1 121 ? -17.12979 0.40114   -12.09720 1.000 32.87870 ? 121 SER A O   1 
ATOM   934  C  CB  . SER A 1 121 ? -19.09532 0.24078   -9.89776  1.000 34.38900 ? 121 SER A CB  1 
ATOM   935  O  OG  . SER A 1 121 ? -18.21156 0.24452   -8.79305  1.000 49.87767 ? 121 SER A OG  1 
ATOM   936  N  N   . PRO A 1 122 ? -16.60826 2.38698   -11.18875 1.000 31.12875 ? 122 PRO A N   1 
ATOM   937  C  CA  . PRO A 1 122 ? -15.24770 2.34557   -11.74351 1.000 36.16612 ? 122 PRO A CA  1 
ATOM   938  C  C   . PRO A 1 122 ? -14.44922 1.18662   -11.16559 1.000 33.61554 ? 122 PRO A C   1 
ATOM   939  O  O   . PRO A 1 122 ? -14.45312 0.94929   -9.95619  1.000 37.56997 ? 122 PRO A O   1 
ATOM   940  C  CB  . PRO A 1 122 ? -14.65542 3.70050   -11.33400 1.000 35.27589 ? 122 PRO A CB  1 
ATOM   941  C  CG  . PRO A 1 122 ? -15.84365 4.57498   -11.05689 1.000 36.43080 ? 122 PRO A CG  1 
ATOM   942  C  CD  . PRO A 1 122 ? -16.88728 3.65759   -10.49979 1.000 39.52481 ? 122 PRO A CD  1 
ATOM   943  N  N   . SER A 1 123 ? -13.76268 0.46043   -12.04483 1.000 32.56570 ? 123 SER A N   1 
ATOM   944  C  CA  . SER A 1 123 ? -12.97680 -0.69677  -11.64247 1.000 32.11711 ? 123 SER A CA  1 
ATOM   945  C  C   . SER A 1 123 ? -11.48619 -0.56063  -11.91325 1.000 28.93994 ? 123 SER A C   1 
ATOM   946  O  O   . SER A 1 123 ? -10.68933 -1.11160  -11.15045 1.000 31.70346 ? 123 SER A O   1 
ATOM   947  C  CB  . SER A 1 123 ? -13.48643 -1.96340  -12.34566 1.000 31.69394 ? 123 SER A CB  1 
ATOM   948  O  OG  . SER A 1 123 ? -13.15101 -1.94645  -13.72056 1.000 41.39841 ? 123 SER A OG  1 
ATOM   949  N  N   . GLY A 1 124 ? -11.08665 0.14504   -12.96639 1.000 28.51894 ? 124 GLY A N   1 
ATOM   950  C  CA  . GLY A 1 124 ? -9.67658  0.27602   -13.28152 1.000 35.33850 ? 124 GLY A CA  1 
ATOM   951  C  C   . GLY A 1 124 ? -9.43464  1.39622   -14.26641 1.000 32.98436 ? 124 GLY A C   1 
ATOM   952  O  O   . GLY A 1 124 ? -10.33482 1.80582   -15.00770 1.000 30.44203 ? 124 GLY A O   1 
ATOM   953  N  N   . VAL A 1 125 ? -8.19503  1.88406   -14.26655 1.000 27.23649 ? 125 VAL A N   1 
ATOM   954  C  CA  . VAL A 1 125 ? -7.77696  2.98269   -15.12817 1.000 32.39776 ? 125 VAL A CA  1 
ATOM   955  C  C   . VAL A 1 125 ? -6.49565  2.58092   -15.84810 1.000 32.29571 ? 125 VAL A C   1 
ATOM   956  O  O   . VAL A 1 125 ? -5.63194  1.90985   -15.27144 1.000 33.99278 ? 125 VAL A O   1 
ATOM   957  C  CB  . VAL A 1 125 ? -7.58223  4.29173   -14.32680 1.000 30.40899 ? 125 VAL A CB  1 
ATOM   958  C  CG1 . VAL A 1 125 ? -6.47507  4.14321   -13.29566 1.000 32.95202 ? 125 VAL A CG1 1 
ATOM   959  C  CG2 . VAL A 1 125 ? -7.30100  5.46485   -15.25630 1.000 30.33436 ? 125 VAL A CG2 1 
ATOM   960  N  N   . TYR A 1 126 ? -6.38197  2.97060   -17.11808 1.000 27.43050 ? 126 TYR A N   1 
ATOM   961  C  CA  . TYR A 1 126 ? -5.17899  2.68455   -17.88781 1.000 32.24703 ? 126 TYR A CA  1 
ATOM   962  C  C   . TYR A 1 126 ? -5.03376  3.69837   -19.01252 1.000 32.02131 ? 126 TYR A C   1 
ATOM   963  O  O   . TYR A 1 126 ? -5.99540  4.36011   -19.41396 1.000 31.10817 ? 126 TYR A O   1 
ATOM   964  C  CB  . TYR A 1 126 ? -5.18397  1.25681   -18.45495 1.000 30.17998 ? 126 TYR A CB  1 
ATOM   965  C  CG  . TYR A 1 126 ? -6.37932  0.91688   -19.31995 1.000 35.55732 ? 126 TYR A CG  1 
ATOM   966  C  CD1 . TYR A 1 126 ? -6.37848  1.18585   -20.68448 1.000 34.29783 ? 126 TYR A CD1 1 
ATOM   967  C  CD2 . TYR A 1 126 ? -7.50217  0.31169   -18.77460 1.000 37.05200 ? 126 TYR A CD2 1 
ATOM   968  C  CE1 . TYR A 1 126 ? -7.46488  0.86927   -21.47648 1.000 34.38921 ? 126 TYR A CE1 1 
ATOM   969  C  CE2 . TYR A 1 126 ? -8.59403  -0.00985  -19.55893 1.000 32.61431 ? 126 TYR A CE2 1 
ATOM   970  C  CZ  . TYR A 1 126 ? -8.57060  0.27195   -20.90842 1.000 29.62020 ? 126 TYR A CZ  1 
ATOM   971  O  OH  . TYR A 1 126 ? -9.65618  -0.04480  -21.69410 1.000 34.69537 ? 126 TYR A OH  1 
ATOM   972  N  N   . GLN A 1 127 ? -3.80869  3.80246   -19.51727 1.000 29.61510 ? 127 GLN A N   1 
ATOM   973  C  CA  . GLN A 1 127 ? -3.45857  4.70945   -20.59990 1.000 32.49273 ? 127 GLN A CA  1 
ATOM   974  C  C   . GLN A 1 127 ? -3.42086  3.94692   -21.91795 1.000 36.96813 ? 127 GLN A C   1 
ATOM   975  O  O   . GLN A 1 127 ? -2.98041  2.79452   -21.96550 1.000 39.19244 ? 127 GLN A O   1 
ATOM   976  C  CB  . GLN A 1 127 ? -2.09796  5.36080   -20.33579 1.000 32.76535 ? 127 GLN A CB  1 
ATOM   977  C  CG  . GLN A 1 127 ? -1.68700  6.42184   -21.34180 1.000 34.52155 ? 127 GLN A CG  1 
ATOM   978  C  CD  . GLN A 1 127 ? -2.26063  7.78979   -21.01806 1.000 39.07030 ? 127 GLN A CD  1 
ATOM   979  O  OE1 . GLN A 1 127 ? -3.14322  7.92332   -20.16773 1.000 34.38961 ? 127 GLN A OE1 1 
ATOM   980  N  NE2 . GLN A 1 127 ? -1.75242  8.81777   -21.69116 1.000 36.15583 ? 127 GLN A NE2 1 
ATOM   981  N  N   . CYS A 1 128 ? -3.88750  4.59142   -22.98475 1.000 33.61751 ? 128 CYS A N   1 
ATOM   982  C  CA  . CYS A 1 128 ? -3.83452  4.01000   -24.32142 1.000 33.43110 ? 128 CYS A CA  1 
ATOM   983  C  C   . CYS A 1 128 ? -3.83766  5.14532   -25.33821 1.000 34.72898 ? 128 CYS A C   1 
ATOM   984  O  O   . CYS A 1 128 ? -3.84023  6.32587   -24.98020 1.000 34.19948 ? 128 CYS A O   1 
ATOM   985  C  CB  . CYS A 1 128 ? -4.99202  3.03443   -24.55402 1.000 35.11532 ? 128 CYS A CB  1 
ATOM   986  S  SG  . CYS A 1 128 ? -6.63202  3.77596   -24.45244 1.000 42.02693 ? 128 CYS A SG  1 
ATOM   987  N  N   . ALA A 1 129 ? -3.83591  4.77911   -26.61758 1.000 39.39474 ? 129 ALA A N   1 
ATOM   988  C  CA  . ALA A 1 129 ? -3.75112  5.74925   -27.69761 1.000 36.11149 ? 129 ALA A CA  1 
ATOM   989  C  C   . ALA A 1 129 ? -4.74551  5.40737   -28.79576 1.000 31.36811 ? 129 ALA A C   1 
ATOM   990  O  O   . ALA A 1 129 ? -5.07361  4.23946   -29.02087 1.000 36.39511 ? 129 ALA A O   1 
ATOM   991  C  CB  . ALA A 1 129 ? -2.33671  5.80797   -28.29132 1.000 31.29345 ? 129 ALA A CB  1 
ATOM   992  N  N   . MET A 1 130 ? -5.22405  6.44574   -29.47477 1.000 28.21778 ? 130 MET A N   1 
ATOM   993  C  CA  . MET A 1 130 ? -6.00797  6.26266   -30.68898 1.000 31.86200 ? 130 MET A CA  1 
ATOM   994  C  C   . MET A 1 130 ? -5.09756  5.74595   -31.79755 1.000 35.13301 ? 130 MET A C   1 
ATOM   995  O  O   . MET A 1 130 ? -4.12852  6.41533   -32.17621 1.000 28.11322 ? 130 MET A O   1 
ATOM   996  C  CB  . MET A 1 130 ? -6.66221  7.58247   -31.09230 1.000 29.84448 ? 130 MET A CB  1 
ATOM   997  C  CG  . MET A 1 130 ? -7.44230  7.54592   -32.39537 1.000 25.20797 ? 130 MET A CG  1 
ATOM   998  S  SD  . MET A 1 130 ? -8.94394  6.55875   -32.28595 1.000 37.72260 ? 130 MET A SD  1 
ATOM   999  C  CE  . MET A 1 130 ? -9.73320  7.29934   -30.85729 1.000 35.70174 ? 130 MET A CE  1 
ATOM   1000 N  N   . ARG A 1 131 ? -5.39371  4.54941   -32.30158 1.000 31.28912 ? 131 ARG A N   1 
ATOM   1001 C  CA  . ARG A 1 131 ? -4.58164  3.94969   -33.34502 1.000 27.14464 ? 131 ARG A CA  1 
ATOM   1002 C  C   . ARG A 1 131 ? -4.84125  4.63725   -34.68231 1.000 28.43656 ? 131 ARG A C   1 
ATOM   1003 O  O   . ARG A 1 131 ? -5.85932  5.31226   -34.86048 1.000 33.75130 ? 131 ARG A O   1 
ATOM   1004 C  CB  . ARG A 1 131 ? -4.87745  2.45552   -33.45516 1.000 27.55642 ? 131 ARG A CB  1 
ATOM   1005 C  CG  . ARG A 1 131 ? -4.66196  1.66454   -32.17245 1.000 30.45778 ? 131 ARG A CG  1 
ATOM   1006 C  CD  . ARG A 1 131 ? -3.27126  1.87698   -31.60033 1.000 28.56998 ? 131 ARG A CD  1 
ATOM   1007 N  NE  . ARG A 1 131 ? -2.23042  1.62504   -32.58797 1.000 35.22051 ? 131 ARG A NE  1 
ATOM   1008 C  CZ  . ARG A 1 131 ? -0.93041  1.71602   -32.34389 1.000 33.71048 ? 131 ARG A CZ  1 
ATOM   1009 N  NH1 . ARG A 1 131 ? -0.47308  2.03080   -31.14339 1.000 25.34136 ? 131 ARG A NH1 1 
ATOM   1010 N  NH2 . ARG A 1 131 ? -0.06761  1.48621   -33.32970 1.000 35.02071 ? 131 ARG A NH2 1 
ATOM   1011 N  N   . PRO A 1 132 ? -3.92180  4.49617   -35.63979 1.000 30.11915 ? 132 PRO A N   1 
ATOM   1012 C  CA  . PRO A 1 132 ? -4.15976  5.07689   -36.97064 1.000 32.13703 ? 132 PRO A CA  1 
ATOM   1013 C  C   . PRO A 1 132 ? -5.35908  4.48787   -37.69543 1.000 28.52642 ? 132 PRO A C   1 
ATOM   1014 O  O   . PRO A 1 132 ? -5.90950  5.15701   -38.57611 1.000 32.06480 ? 132 PRO A O   1 
ATOM   1015 C  CB  . PRO A 1 132 ? -2.85143  4.78554   -37.71781 1.000 26.15195 ? 132 PRO A CB  1 
ATOM   1016 C  CG  . PRO A 1 132 ? -1.83493  4.67227   -36.64448 1.000 31.49615 ? 132 PRO A CG  1 
ATOM   1017 C  CD  . PRO A 1 132 ? -2.53470  4.02303   -35.49016 1.000 23.83328 ? 132 PRO A CD  1 
ATOM   1018 N  N   . ASN A 1 133 ? -5.77914  3.26475   -37.37177 1.000 26.03340 ? 133 ASN A N   1 
ATOM   1019 C  CA  . ASN A 1 133 ? -7.00346  2.71013   -37.93471 1.000 34.77830 ? 133 ASN A CA  1 
ATOM   1020 C  C   . ASN A 1 133 ? -8.23577  3.06607   -37.10936 1.000 35.14943 ? 133 ASN A C   1 
ATOM   1021 O  O   . ASN A 1 133 ? -9.28576  2.43688   -37.27925 1.000 33.15054 ? 133 ASN A O   1 
ATOM   1022 C  CB  . ASN A 1 133 ? -6.89086  1.18807   -38.09829 1.000 35.01675 ? 133 ASN A CB  1 
ATOM   1023 C  CG  . ASN A 1 133 ? -6.75501  0.44879   -36.77630 1.000 30.71716 ? 133 ASN A CG  1 
ATOM   1024 O  OD1 . ASN A 1 133 ? -6.86461  1.02998   -35.69883 1.000 31.78767 ? 133 ASN A OD1 1 
ATOM   1025 N  ND2 . ASN A 1 133 ? -6.51866  -0.85442  -36.86141 1.000 34.55499 ? 133 ASN A ND2 1 
ATOM   1026 N  N   . PHE A 1 134 ? -8.11614  4.04604   -36.21072 1.000 36.73676 ? 134 PHE A N   1 
ATOM   1027 C  CA  . PHE A 1 134 ? -9.21778  4.60740   -35.43355 1.000 30.66387 ? 134 PHE A CA  1 
ATOM   1028 C  C   . PHE A 1 134 ? -9.81794  3.62240   -34.43998 1.000 31.52123 ? 134 PHE A C   1 
ATOM   1029 O  O   . PHE A 1 134 ? -10.92576 3.84475   -33.94425 1.000 34.36438 ? 134 PHE A O   1 
ATOM   1030 C  CB  . PHE A 1 134 ? -10.31325 5.16460   -36.34631 1.000 28.78481 ? 134 PHE A CB  1 
ATOM   1031 C  CG  . PHE A 1 134 ? -9.85633  6.30706   -37.20011 1.000 31.88145 ? 134 PHE A CG  1 
ATOM   1032 C  CD1 . PHE A 1 134 ? -9.85557  7.59965   -36.70285 1.000 29.92940 ? 134 PHE A CD1 1 
ATOM   1033 C  CD2 . PHE A 1 134 ? -9.41684  6.09082   -38.49407 1.000 33.32817 ? 134 PHE A CD2 1 
ATOM   1034 C  CE1 . PHE A 1 134 ? -9.43013  8.65656   -37.48234 1.000 30.00321 ? 134 PHE A CE1 1 
ATOM   1035 C  CE2 . PHE A 1 134 ? -8.98920  7.14477   -39.28000 1.000 34.10349 ? 134 PHE A CE2 1 
ATOM   1036 C  CZ  . PHE A 1 134 ? -8.99658  8.42886   -38.77273 1.000 35.44095 ? 134 PHE A CZ  1 
ATOM   1037 N  N   . THR A 1 135 ? -9.11909  2.53780   -34.13193 1.000 30.79133 ? 135 THR A N   1 
ATOM   1038 C  CA  . THR A 1 135 ? -9.48347  1.68534   -33.01307 1.000 30.25829 ? 135 THR A CA  1 
ATOM   1039 C  C   . THR A 1 135 ? -8.61526  2.03218   -31.81168 1.000 29.83401 ? 135 THR A C   1 
ATOM   1040 O  O   . THR A 1 135 ? -7.64246  2.78246   -31.90912 1.000 28.91790 ? 135 THR A O   1 
ATOM   1041 C  CB  . THR A 1 135 ? -9.32236  0.20608   -33.37184 1.000 31.80022 ? 135 THR A CB  1 
ATOM   1042 O  OG1 . THR A 1 135 ? -7.94935  -0.05708  -33.68821 1.000 33.22308 ? 135 THR A OG1 1 
ATOM   1043 C  CG2 . THR A 1 135 ? -10.19126 -0.14787  -34.56420 1.000 34.24099 ? 135 THR A CG2 1 
ATOM   1044 N  N   . ILE A 1 136 ? -8.98755  1.48848   -30.66090 1.000 26.00362 ? 136 ILE A N   1 
ATOM   1045 C  CA  . ILE A 1 136 ? -8.12927  1.54351   -29.48787 1.000 30.39612 ? 136 ILE A CA  1 
ATOM   1046 C  C   . ILE A 1 136 ? -7.89965  0.11791   -29.01677 1.000 30.60057 ? 136 ILE A C   1 
ATOM   1047 O  O   . ILE A 1 136 ? -8.76230  -0.75463  -29.15908 1.000 30.41436 ? 136 ILE A O   1 
ATOM   1048 C  CB  . ILE A 1 136 ? -8.70211  2.41963   -28.34643 1.000 32.32011 ? 136 ILE A CB  1 
ATOM   1049 C  CG1 . ILE A 1 136 ? -9.78957  1.67936   -27.56561 1.000 32.59313 ? 136 ILE A CG1 1 
ATOM   1050 C  CG2 . ILE A 1 136 ? -9.23600  3.73559   -28.89012 1.000 33.12002 ? 136 ILE A CG2 1 
ATOM   1051 C  CD1 . ILE A 1 136 ? -10.32372 2.46548   -26.39094 1.000 37.94386 ? 136 ILE A CD1 1 
ATOM   1052 N  N   . LYS A 1 137 ? -6.70373  -0.12392  -28.48968 1.000 29.31607 ? 137 LYS A N   1 
ATOM   1053 C  CA  . LYS A 1 137 ? -6.35167  -1.42227  -27.92816 1.000 35.61775 ? 137 LYS A CA  1 
ATOM   1054 C  C   . LYS A 1 137 ? -6.57870  -1.34418  -26.42262 1.000 33.61737 ? 137 LYS A C   1 
ATOM   1055 O  O   . LYS A 1 137 ? -5.65167  -1.17882  -25.63117 1.000 35.81685 ? 137 LYS A O   1 
ATOM   1056 C  CB  . LYS A 1 137 ? -4.91068  -1.78977  -28.27548 1.000 29.16984 ? 137 LYS A CB  1 
ATOM   1057 C  CG  . LYS A 1 137 ? -4.70213  -2.16953  -29.73199 1.000 34.40126 ? 137 LYS A CG  1 
ATOM   1058 C  CD  . LYS A 1 137 ? -3.22995  -2.42921  -30.02682 1.000 37.01490 ? 137 LYS A CD  1 
ATOM   1059 C  CE  . LYS A 1 137 ? -3.02782  -2.91157  -31.45125 1.000 40.75769 ? 137 LYS A CE  1 
ATOM   1060 N  NZ  . LYS A 1 137 ? -3.66078  -4.24029  -31.67340 1.000 55.54437 ? 137 LYS A NZ  1 
ATOM   1061 N  N   . GLY A 1 138 ? -7.84776  -1.45603  -26.03123 1.000 36.45426 ? 138 GLY A N   1 
ATOM   1062 C  CA  . GLY A 1 138 ? -8.23923  -1.34841  -24.64502 1.000 31.07782 ? 138 GLY A CA  1 
ATOM   1063 C  C   . GLY A 1 138 ? -8.34050  -2.70071  -23.96090 1.000 32.73619 ? 138 GLY A C   1 
ATOM   1064 O  O   . GLY A 1 138 ? -7.99898  -3.74922  -24.51176 1.000 35.66556 ? 138 GLY A O   1 
ATOM   1065 N  N   . SER A 1 139 ? -8.80446  -2.65728  -22.71479 1.000 29.99075 ? 139 SER A N   1 
ATOM   1066 C  CA  . SER A 1 139 ? -9.14638  -3.85392  -21.95662 1.000 33.27451 ? 139 SER A CA  1 
ATOM   1067 C  C   . SER A 1 139 ? -10.58211 -3.67884  -21.48987 1.000 32.70095 ? 139 SER A C   1 
ATOM   1068 O  O   . SER A 1 139 ? -10.84529 -2.89634  -20.57183 1.000 31.50984 ? 139 SER A O   1 
ATOM   1069 C  CB  . SER A 1 139 ? -8.20073  -4.06039  -20.77700 1.000 35.56884 ? 139 SER A CB  1 
ATOM   1070 O  OG  . SER A 1 139 ? -8.60728  -5.17094  -19.99913 1.000 37.74203 ? 139 SER A OG  1 
ATOM   1071 N  N   . PHE A 1 140 ? -11.50675 -4.39439  -22.12682 1.000 30.36979 ? 140 PHE A N   1 
ATOM   1072 C  CA  . PHE A 1 140 ? -12.93170 -4.21342  -21.88643 1.000 36.45507 ? 140 PHE A CA  1 
ATOM   1073 C  C   . PHE A 1 140 ? -13.62948 -5.56184  -21.80724 1.000 34.63795 ? 140 PHE A C   1 
ATOM   1074 O  O   . PHE A 1 140 ? -13.37900 -6.44505  -22.63201 1.000 40.51159 ? 140 PHE A O   1 
ATOM   1075 C  CB  . PHE A 1 140 ? -13.56688 -3.36425  -22.99330 1.000 33.43946 ? 140 PHE A CB  1 
ATOM   1076 C  CG  . PHE A 1 140 ? -13.23278 -1.90385  -22.90873 1.000 31.74223 ? 140 PHE A CG  1 
ATOM   1077 C  CD1 . PHE A 1 140 ? -13.52113 -1.18134  -21.76150 1.000 32.91112 ? 140 PHE A CD1 1 
ATOM   1078 C  CD2 . PHE A 1 140 ? -12.66066 -1.24620  -23.98379 1.000 24.89179 ? 140 PHE A CD2 1 
ATOM   1079 C  CE1 . PHE A 1 140 ? -13.23080 0.17099   -21.68383 1.000 31.11867 ? 140 PHE A CE1 1 
ATOM   1080 C  CE2 . PHE A 1 140 ? -12.37186 0.10382   -23.91618 1.000 30.26067 ? 140 PHE A CE2 1 
ATOM   1081 C  CZ  . PHE A 1 140 ? -12.65859 0.81433   -22.76321 1.000 30.98261 ? 140 PHE A CZ  1 
ATOM   1082 N  N   . LEU A 1 141 ? -14.50365 -5.71047  -20.81948 1.000 37.84572 ? 141 LEU A N   1 
ATOM   1083 C  CA  . LEU A 1 141 ? -15.35939 -6.87788  -20.68337 1.000 33.15609 ? 141 LEU A CA  1 
ATOM   1084 C  C   . LEU A 1 141 ? -16.80253 -6.49356  -20.98061 1.000 35.04568 ? 141 LEU A C   1 
ATOM   1085 O  O   . LEU A 1 141 ? -17.13213 -5.32029  -21.17162 1.000 34.00685 ? 141 LEU A O   1 
ATOM   1086 C  CB  . LEU A 1 141 ? -15.24764 -7.47988  -19.27750 1.000 34.53779 ? 141 LEU A CB  1 
ATOM   1087 C  CG  . LEU A 1 141 ? -13.86484 -7.94665  -18.81905 1.000 37.73809 ? 141 LEU A CG  1 
ATOM   1088 C  CD1 . LEU A 1 141 ? -13.92626 -8.44907  -17.38641 1.000 38.90699 ? 141 LEU A CD1 1 
ATOM   1089 C  CD2 . LEU A 1 141 ? -13.32160 -9.02445  -19.74589 1.000 35.87395 ? 141 LEU A CD2 1 
ATOM   1090 N  N   . ASN A 1 142 ? -17.66585 -7.50548  -21.02845 1.000 40.61211 ? 142 ASN A N   1 
ATOM   1091 C  CA  . ASN A 1 142 ? -19.09350 -7.25412  -21.16575 1.000 36.01596 ? 142 ASN A CA  1 
ATOM   1092 C  C   . ASN A 1 142 ? -19.57814 -6.37323  -20.02226 1.000 32.67083 ? 142 ASN A C   1 
ATOM   1093 O  O   . ASN A 1 142 ? -19.26405 -6.62273  -18.85553 1.000 31.45693 ? 142 ASN A O   1 
ATOM   1094 C  CB  . ASN A 1 142 ? -19.86319 -8.57464  -21.18508 1.000 38.99996 ? 142 ASN A CB  1 
ATOM   1095 C  CG  . ASN A 1 142 ? -20.41065 -8.91014  -22.55783 1.000 50.36852 ? 142 ASN A CG  1 
ATOM   1096 O  OD1 . ASN A 1 142 ? -21.47612 -8.42936  -22.94897 1.000 56.60597 ? 142 ASN A OD1 1 
ATOM   1097 N  ND2 . ASN A 1 142 ? -19.68467 -9.74051  -23.29745 1.000 47.12335 ? 142 ASN A ND2 1 
ATOM   1098 N  N   . GLY A 1 143 ? -20.33448 -5.33239  -20.36162 1.000 33.06575 ? 143 GLY A N   1 
ATOM   1099 C  CA  . GLY A 1 143 ? -20.81074 -4.38030  -19.38258 1.000 32.01986 ? 143 GLY A CA  1 
ATOM   1100 C  C   . GLY A 1 143 ? -20.03719 -3.08212  -19.32434 1.000 33.79887 ? 143 GLY A C   1 
ATOM   1101 O  O   . GLY A 1 143 ? -20.42963 -2.18299  -18.57034 1.000 33.74484 ? 143 GLY A O   1 
ATOM   1102 N  N   . SER A 1 144 ? -18.96501 -2.94834  -20.10253 1.000 34.51200 ? 144 SER A N   1 
ATOM   1103 C  CA  . SER A 1 144 ? -18.09229 -1.78418  -20.03889 1.000 30.58481 ? 144 SER A CA  1 
ATOM   1104 C  C   . SER A 1 144 ? -18.51070 -0.66588  -20.98053 1.000 24.57157 ? 144 SER A C   1 
ATOM   1105 O  O   . SER A 1 144 ? -17.85731 0.38119   -20.99547 1.000 26.49643 ? 144 SER A O   1 
ATOM   1106 C  CB  . SER A 1 144 ? -16.64666 -2.19019  -20.34414 1.000 24.55333 ? 144 SER A CB  1 
ATOM   1107 O  OG  . SER A 1 144 ? -16.53786 -2.76630  -21.63301 1.000 27.67179 ? 144 SER A OG  1 
ATOM   1108 N  N   . CYS A 1 145 ? -19.56437 -0.86029  -21.76949 1.000 30.05996 ? 145 CYS A N   1 
ATOM   1109 C  CA  . CYS A 1 145 ? -20.03704 0.20155   -22.64701 1.000 28.38917 ? 145 CYS A CA  1 
ATOM   1110 C  C   . CYS A 1 145 ? -20.44059 1.42218   -21.83034 1.000 31.94773 ? 145 CYS A C   1 
ATOM   1111 O  O   . CYS A 1 145 ? -20.98047 1.30356   -20.72666 1.000 29.66886 ? 145 CYS A O   1 
ATOM   1112 C  CB  . CYS A 1 145 ? -21.21447 -0.28710  -23.48900 1.000 38.74173 ? 145 CYS A CB  1 
ATOM   1113 S  SG  . CYS A 1 145 ? -20.74528 -1.42928  -24.80157 1.000 42.34765 ? 145 CYS A SG  1 
ATOM   1114 N  N   . GLY A 1 146 ? -20.16534 2.60401   -22.37758 1.000 27.80941 ? 146 GLY A N   1 
ATOM   1115 C  CA  . GLY A 1 146 ? -20.33315 3.83845   -21.64903 1.000 27.97299 ? 146 GLY A CA  1 
ATOM   1116 C  C   . GLY A 1 146 ? -19.09545 4.31902   -20.92454 1.000 32.01969 ? 146 GLY A C   1 
ATOM   1117 O  O   . GLY A 1 146 ? -19.06597 5.47747   -20.48886 1.000 30.27828 ? 146 GLY A O   1 
ATOM   1118 N  N   . SER A 1 147 ? -18.08215 3.46700   -20.76506 1.000 30.59136 ? 147 SER A N   1 
ATOM   1119 C  CA  . SER A 1 147 ? -16.80279 3.92121   -20.23616 1.000 23.38412 ? 147 SER A CA  1 
ATOM   1120 C  C   . SER A 1 147 ? -16.23483 5.02021   -21.12525 1.000 25.71262 ? 147 SER A C   1 
ATOM   1121 O  O   . SER A 1 147 ? -16.43607 5.03134   -22.34265 1.000 31.22219 ? 147 SER A O   1 
ATOM   1122 C  CB  . SER A 1 147 ? -15.81317 2.75797   -20.14299 1.000 27.77001 ? 147 SER A CB  1 
ATOM   1123 O  OG  . SER A 1 147 ? -16.29739 1.73479   -19.29138 1.000 26.51771 ? 147 SER A OG  1 
ATOM   1124 N  N   . VAL A 1 148 ? -15.52079 5.95598   -20.50846 1.000 25.77626 ? 148 VAL A N   1 
ATOM   1125 C  CA  . VAL A 1 148 ? -15.05434 7.13993   -21.21495 1.000 26.78999 ? 148 VAL A CA  1 
ATOM   1126 C  C   . VAL A 1 148 ? -13.53786 7.22957   -21.13284 1.000 32.99687 ? 148 VAL A C   1 
ATOM   1127 O  O   . VAL A 1 148 ? -12.91167 6.75528   -20.17864 1.000 28.35265 ? 148 VAL A O   1 
ATOM   1128 C  CB  . VAL A 1 148 ? -15.70709 8.42690   -20.66454 1.000 31.56679 ? 148 VAL A CB  1 
ATOM   1129 C  CG1 . VAL A 1 148 ? -17.21857 8.36973   -20.84616 1.000 28.69984 ? 148 VAL A CG1 1 
ATOM   1130 C  CG2 . VAL A 1 148 ? -15.34914 8.62402   -19.20202 1.000 24.51137 ? 148 VAL A CG2 1 
ATOM   1131 N  N   . GLY A 1 149 ? -12.95039 7.83523   -22.16370 1.000 29.07748 ? 149 GLY A N   1 
ATOM   1132 C  CA  . GLY A 1 149 ? -11.54017 8.17216   -22.18163 1.000 27.23769 ? 149 GLY A CA  1 
ATOM   1133 C  C   . GLY A 1 149 ? -11.37791 9.67249   -22.03480 1.000 34.13608 ? 149 GLY A C   1 
ATOM   1134 O  O   . GLY A 1 149 ? -12.26332 10.44255  -22.41565 1.000 34.79241 ? 149 GLY A O   1 
ATOM   1135 N  N   . PHE A 1 150 ? -10.23866 10.09335  -21.49060 1.000 31.49384 ? 150 PHE A N   1 
ATOM   1136 C  CA  . PHE A 1 150 ? -10.11072 11.48823  -21.09715 1.000 31.76986 ? 150 PHE A CA  1 
ATOM   1137 C  C   . PHE A 1 150 ? -8.64755  11.86087  -20.91853 1.000 34.82316 ? 150 PHE A C   1 
ATOM   1138 O  O   . PHE A 1 150 ? -7.78331  11.00502  -20.70780 1.000 30.22508 ? 150 PHE A O   1 
ATOM   1139 C  CB  . PHE A 1 150 ? -10.87499 11.76138  -19.79731 1.000 29.09197 ? 150 PHE A CB  1 
ATOM   1140 C  CG  . PHE A 1 150 ? -10.36365 10.97337  -18.62237 1.000 29.28859 ? 150 PHE A CG  1 
ATOM   1141 C  CD1 . PHE A 1 150 ? -10.76904 9.66220   -18.41619 1.000 29.78771 ? 150 PHE A CD1 1 
ATOM   1142 C  CD2 . PHE A 1 150 ? -9.47168  11.54001  -17.73025 1.000 26.19263 ? 150 PHE A CD2 1 
ATOM   1143 C  CE1 . PHE A 1 150 ? -10.29574 8.93683   -17.33938 1.000 29.54098 ? 150 PHE A CE1 1 
ATOM   1144 C  CE2 . PHE A 1 150 ? -8.99535  10.82028  -16.65169 1.000 32.86963 ? 150 PHE A CE2 1 
ATOM   1145 C  CZ  . PHE A 1 150 ? -9.40866  9.51681   -16.45577 1.000 32.00038 ? 150 PHE A CZ  1 
ATOM   1146 N  N   . ASN A 1 151 ? -8.39339  13.16385  -21.00274 1.000 33.68206 ? 151 ASN A N   1 
ATOM   1147 C  CA  . ASN A 1 151 ? -7.17894  13.78726  -20.50696 1.000 34.27485 ? 151 ASN A CA  1 
ATOM   1148 C  C   . ASN A 1 151 ? -7.56155  14.84602  -19.48145 1.000 39.00208 ? 151 ASN A C   1 
ATOM   1149 O  O   . ASN A 1 151 ? -8.68482  15.35776  -19.47793 1.000 36.38573 ? 151 ASN A O   1 
ATOM   1150 C  CB  . ASN A 1 151 ? -6.36266  14.42648  -21.63687 1.000 29.53477 ? 151 ASN A CB  1 
ATOM   1151 C  CG  . ASN A 1 151 ? -5.82494  13.40680  -22.61461 1.000 36.30390 ? 151 ASN A CG  1 
ATOM   1152 O  OD1 . ASN A 1 151 ? -4.74041  12.85808  -22.42024 1.000 39.94887 ? 151 ASN A OD1 1 
ATOM   1153 N  ND2 . ASN A 1 151 ? -6.57955  13.14798  -23.67659 1.000 30.94088 ? 151 ASN A ND2 1 
ATOM   1154 N  N   . ILE A 1 152 ? -6.62096  15.16620  -18.59813 1.000 34.47463 ? 152 ILE A N   1 
ATOM   1155 C  CA  . ILE A 1 152 ? -6.78809  16.24123  -17.62889 1.000 37.22106 ? 152 ILE A CA  1 
ATOM   1156 C  C   . ILE A 1 152 ? -5.62860  17.21005  -17.79786 1.000 47.02059 ? 152 ILE A C   1 
ATOM   1157 O  O   . ILE A 1 152 ? -4.46125  16.80574  -17.74775 1.000 45.25530 ? 152 ILE A O   1 
ATOM   1158 C  CB  . ILE A 1 152 ? -6.85857  15.71358  -16.18455 1.000 36.52241 ? 152 ILE A CB  1 
ATOM   1159 C  CG1 . ILE A 1 152 ? -7.98198  14.68590  -16.04497 1.000 31.29572 ? 152 ILE A CG1 1 
ATOM   1160 C  CG2 . ILE A 1 152 ? -7.08082  16.86262  -15.21643 1.000 40.98031 ? 152 ILE A CG2 1 
ATOM   1161 C  CD1 . ILE A 1 152 ? -8.13910  14.13945  -14.64577 1.000 30.96345 ? 152 ILE A CD1 1 
ATOM   1162 N  N   . ASP A 1 153 ? -5.95008  18.48096  -18.01316 1.000 46.78205 ? 153 ASP A N   1 
ATOM   1163 C  CA  . ASP A 1 153 ? -4.95307  19.52568  -18.19662 1.000 49.46477 ? 153 ASP A CA  1 
ATOM   1164 C  C   . ASP A 1 153 ? -5.19109  20.58883  -17.13822 1.000 58.85083 ? 153 ASP A C   1 
ATOM   1165 O  O   . ASP A 1 153 ? -6.25537  21.21702  -17.11622 1.000 61.24276 ? 153 ASP A O   1 
ATOM   1166 C  CB  . ASP A 1 153 ? -5.02929  20.10913  -19.60661 1.000 51.00036 ? 153 ASP A CB  1 
ATOM   1167 C  CG  . ASP A 1 153 ? -4.62238  19.10572  -20.66894 1.000 59.11293 ? 153 ASP A CG  1 
ATOM   1168 O  OD1 . ASP A 1 153 ? -3.43405  18.72056  -20.69934 1.000 60.32152 ? 153 ASP A OD1 1 
ATOM   1169 O  OD2 . ASP A 1 153 ? -5.49503  18.68253  -21.45799 1.000 55.55121 ? 153 ASP A OD2 1 
ATOM   1170 N  N   . TYR A 1 154 ? -4.20271  20.77556  -16.26191 1.000 63.85328 ? 154 TYR A N   1 
ATOM   1171 C  CA  . TYR A 1 154 ? -4.36084  21.55953  -15.04332 1.000 64.96681 ? 154 TYR A CA  1 
ATOM   1172 C  C   . TYR A 1 154 ? -5.49285  20.96597  -14.21096 1.000 68.50221 ? 154 TYR A C   1 
ATOM   1173 O  O   . TYR A 1 154 ? -5.27831  19.98468  -13.49200 1.000 66.11078 ? 154 TYR A O   1 
ATOM   1174 C  CB  . TYR A 1 154 ? -4.58367  23.03674  -15.37798 1.000 64.13783 ? 154 TYR A CB  1 
ATOM   1175 C  CG  . TYR A 1 154 ? -3.39402  23.63969  -16.09543 1.000 76.81310 ? 154 TYR A CG  1 
ATOM   1176 C  CD1 . TYR A 1 154 ? -2.09874  23.28097  -15.74135 1.000 79.71197 ? 154 TYR A CD1 1 
ATOM   1177 C  CD2 . TYR A 1 154 ? -3.56019  24.54092  -17.13982 1.000 78.36882 ? 154 TYR A CD2 1 
ATOM   1178 C  CE1 . TYR A 1 154 ? -1.00151  23.81384  -16.39298 1.000 70.43614 ? 154 TYR A CE1 1 
ATOM   1179 C  CE2 . TYR A 1 154 ? -2.46440  25.08075  -17.80026 1.000 81.87330 ? 154 TYR A CE2 1 
ATOM   1180 C  CZ  . TYR A 1 154 ? -1.18822  24.71182  -17.42085 1.000 72.00244 ? 154 TYR A CZ  1 
ATOM   1181 O  OH  . TYR A 1 154 ? -0.09435  25.24041  -18.06836 1.000 77.83637 ? 154 TYR A OH  1 
ATOM   1182 N  N   . ASP A 1 155 ? -6.70305  21.52186  -14.30397 1.000 59.83853 ? 155 ASP A N   1 
ATOM   1183 C  CA  . ASP A 1 155 ? -7.84369  20.93319  -13.60921 1.000 57.88116 ? 155 ASP A CA  1 
ATOM   1184 C  C   . ASP A 1 155 ? -9.05812  20.78289  -14.52022 1.000 51.98300 ? 155 ASP A C   1 
ATOM   1185 O  O   . ASP A 1 155 ? -10.18483 20.66890  -14.02758 1.000 50.13346 ? 155 ASP A O   1 
ATOM   1186 C  CB  . ASP A 1 155 ? -8.20931  21.74621  -12.36280 1.000 60.02087 ? 155 ASP A CB  1 
ATOM   1187 C  CG  . ASP A 1 155 ? -8.53127  23.19395  -12.67705 1.000 70.02742 ? 155 ASP A CG  1 
ATOM   1188 O  OD1 . ASP A 1 155 ? -8.29782  23.62877  -13.82435 1.000 66.48917 ? 155 ASP A OD1 1 
ATOM   1189 O  OD2 . ASP A 1 155 ? -9.02174  23.89839  -11.76943 1.000 70.81573 ? 155 ASP A OD2 1 
ATOM   1190 N  N   . CYS A 1 156 ? -8.85434  20.76162  -15.83376 1.000 53.64341 ? 156 CYS A N   1 
ATOM   1191 C  CA  . CYS A 1 156 ? -9.93900  20.63640  -16.79922 1.000 57.07707 ? 156 CYS A CA  1 
ATOM   1192 C  C   . CYS A 1 156 ? -9.90037  19.24283  -17.41284 1.000 38.31334 ? 156 CYS A C   1 
ATOM   1193 O  O   . CYS A 1 156 ? -8.87067  18.82821  -17.95511 1.000 42.52666 ? 156 CYS A O   1 
ATOM   1194 C  CB  . CYS A 1 156 ? -9.82950  21.70898  -17.88281 1.000 51.13962 ? 156 CYS A CB  1 
ATOM   1195 S  SG  . CYS A 1 156 ? -11.23103 21.76346  -19.02127 1.000 50.62066 ? 156 CYS A SG  1 
ATOM   1196 N  N   . VAL A 1 157 ? -11.01694 18.52796  -17.32578 1.000 42.33026 ? 157 VAL A N   1 
ATOM   1197 C  CA  . VAL A 1 157 ? -11.13215 17.18563  -17.88508 1.000 38.80999 ? 157 VAL A CA  1 
ATOM   1198 C  C   . VAL A 1 157 ? -11.65486 17.29820  -19.31125 1.000 43.00277 ? 157 VAL A C   1 
ATOM   1199 O  O   . VAL A 1 157 ? -12.77136 17.77500  -19.53672 1.000 34.72086 ? 157 VAL A O   1 
ATOM   1200 C  CB  . VAL A 1 157 ? -12.05670 16.30465  -17.03189 1.000 35.21285 ? 157 VAL A CB  1 
ATOM   1201 C  CG1 . VAL A 1 157 ? -12.09589 14.88675  -17.58460 1.000 35.16233 ? 157 VAL A CG1 1 
ATOM   1202 C  CG2 . VAL A 1 157 ? -11.60727 16.30882  -15.57981 1.000 33.11598 ? 157 VAL A CG2 1 
ATOM   1203 N  N   . SER A 1 158 ? -10.85385 16.85961  -20.27621 1.000 34.56943 ? 158 SER A N   1 
ATOM   1204 C  CA  . SER A 1 158 ? -11.26179 16.83846  -21.67508 1.000 33.27578 ? 158 SER A CA  1 
ATOM   1205 C  C   . SER A 1 158 ? -11.69059 15.41804  -22.02243 1.000 37.88115 ? 158 SER A C   1 
ATOM   1206 O  O   . SER A 1 158 ? -10.85031 14.51943  -22.13706 1.000 32.17868 ? 158 SER A O   1 
ATOM   1207 C  CB  . SER A 1 158 ? -10.13357 17.31624  -22.58635 1.000 33.20544 ? 158 SER A CB  1 
ATOM   1208 O  OG  . SER A 1 158 ? -8.96737  16.53477  -22.40543 1.000 46.47751 ? 158 SER A OG  1 
ATOM   1209 N  N   . PHE A 1 159 ? -12.99767 15.21583  -22.17552 1.000 34.03899 ? 159 PHE A N   1 
ATOM   1210 C  CA  . PHE A 1 159 ? -13.52876 13.92010  -22.57791 1.000 37.59764 ? 159 PHE A CA  1 
ATOM   1211 C  C   . PHE A 1 159 ? -13.39133 13.76940  -24.08760 1.000 37.26705 ? 159 PHE A C   1 
ATOM   1212 O  O   . PHE A 1 159 ? -13.85516 14.62607  -24.84786 1.000 36.08194 ? 159 PHE A O   1 
ATOM   1213 C  CB  . PHE A 1 159 ? -14.98881 13.78133  -22.15087 1.000 30.53950 ? 159 PHE A CB  1 
ATOM   1214 C  CG  . PHE A 1 159 ? -15.19428 13.81912  -20.66267 1.000 33.14009 ? 159 PHE A CG  1 
ATOM   1215 C  CD1 . PHE A 1 159 ? -15.03839 12.67327  -19.89672 1.000 28.30577 ? 159 PHE A CD1 1 
ATOM   1216 C  CD2 . PHE A 1 159 ? -15.54609 14.99925  -20.02979 1.000 32.74084 ? 159 PHE A CD2 1 
ATOM   1217 C  CE1 . PHE A 1 159 ? -15.22900 12.70819  -18.52235 1.000 33.33324 ? 159 PHE A CE1 1 
ATOM   1218 C  CE2 . PHE A 1 159 ? -15.73749 15.03993  -18.66113 1.000 34.51991 ? 159 PHE A CE2 1 
ATOM   1219 C  CZ  . PHE A 1 159 ? -15.57893 13.89343  -17.90621 1.000 36.72958 ? 159 PHE A CZ  1 
ATOM   1220 N  N   . CYS A 1 160 ? -12.75888 12.68165  -24.52192 1.000 31.69589 ? 160 CYS A N   1 
ATOM   1221 C  CA  . CYS A 1 160 ? -12.48733 12.46754  -25.93278 1.000 31.08241 ? 160 CYS A CA  1 
ATOM   1222 C  C   . CYS A 1 160 ? -13.02582 11.15596  -26.48037 1.000 33.73094 ? 160 CYS A C   1 
ATOM   1223 O  O   . CYS A 1 160 ? -13.01536 10.97049  -27.70265 1.000 37.22301 ? 160 CYS A O   1 
ATOM   1224 C  CB  . CYS A 1 160 ? -10.97553 12.52153  -26.19423 1.000 32.10734 ? 160 CYS A CB  1 
ATOM   1225 S  SG  . CYS A 1 160 ? -10.03935 11.30662  -25.24405 1.000 32.59072 ? 160 CYS A SG  1 
ATOM   1226 N  N   . TYR A 1 161 ? -13.49067 10.24567  -25.63011 1.000 29.39290 ? 161 TYR A N   1 
ATOM   1227 C  CA  . TYR A 1 161 ? -13.86042 8.91667   -26.08838 1.000 29.11495 ? 161 TYR A CA  1 
ATOM   1228 C  C   . TYR A 1 161 ? -14.96025 8.35282   -25.20289 1.000 27.70752 ? 161 TYR A C   1 
ATOM   1229 O  O   . TYR A 1 161 ? -14.96669 8.57791   -23.99138 1.000 31.04519 ? 161 TYR A O   1 
ATOM   1230 C  CB  . TYR A 1 161 ? -12.63995 7.98516   -26.08541 1.000 26.21134 ? 161 TYR A CB  1 
ATOM   1231 C  CG  . TYR A 1 161 ? -12.92965 6.56822   -26.52159 1.000 29.79313 ? 161 TYR A CG  1 
ATOM   1232 C  CD1 . TYR A 1 161 ? -12.93669 6.22291   -27.86666 1.000 26.95222 ? 161 TYR A CD1 1 
ATOM   1233 C  CD2 . TYR A 1 161 ? -13.18291 5.57247   -25.58791 1.000 28.42503 ? 161 TYR A CD2 1 
ATOM   1234 C  CE1 . TYR A 1 161 ? -13.19464 4.92496   -28.26960 1.000 29.30611 ? 161 TYR A CE1 1 
ATOM   1235 C  CE2 . TYR A 1 161 ? -13.44313 4.27336   -25.98071 1.000 27.22533 ? 161 TYR A CE2 1 
ATOM   1236 C  CZ  . TYR A 1 161 ? -13.44771 3.95542   -27.32250 1.000 29.29969 ? 161 TYR A CZ  1 
ATOM   1237 O  OH  . TYR A 1 161 ? -13.70550 2.66177   -27.71782 1.000 29.99070 ? 161 TYR A OH  1 
ATOM   1238 N  N   . MET A 1 162 ? -15.89335 7.63376   -25.82301 1.000 26.08158 ? 162 MET A N   1 
ATOM   1239 C  CA  . MET A 1 162 ? -16.87575 6.82159   -25.11931 1.000 25.16641 ? 162 MET A CA  1 
ATOM   1240 C  C   . MET A 1 162 ? -16.90510 5.45159   -25.77714 1.000 27.18231 ? 162 MET A C   1 
ATOM   1241 O  O   . MET A 1 162 ? -16.96365 5.35408   -27.00628 1.000 28.30095 ? 162 MET A O   1 
ATOM   1242 C  CB  . MET A 1 162 ? -18.26977 7.46183   -25.13937 1.000 27.28178 ? 162 MET A CB  1 
ATOM   1243 C  CG  . MET A 1 162 ? -19.37506 6.53264   -24.64602 1.000 33.50201 ? 162 MET A CG  1 
ATOM   1244 S  SD  . MET A 1 162 ? -20.97286 7.34226   -24.39475 1.000 39.81078 ? 162 MET A SD  1 
ATOM   1245 C  CE  . MET A 1 162 ? -20.67064 8.21716   -22.86192 1.000 35.25500 ? 162 MET A CE  1 
ATOM   1246 N  N   . HIS A 1 163 ? -16.84661 4.39986   -24.96474 1.000 28.46189 ? 163 HIS A N   1 
ATOM   1247 C  CA  . HIS A 1 163 ? -16.71299 3.04674   -25.48711 1.000 29.59717 ? 163 HIS A CA  1 
ATOM   1248 C  C   . HIS A 1 163 ? -18.06583 2.50039   -25.92318 1.000 28.73643 ? 163 HIS A C   1 
ATOM   1249 O  O   . HIS A 1 163 ? -19.04515 2.57106   -25.17467 1.000 28.71130 ? 163 HIS A O   1 
ATOM   1250 C  CB  . HIS A 1 163 ? -16.08893 2.13123   -24.43693 1.000 27.67456 ? 163 HIS A CB  1 
ATOM   1251 C  CG  . HIS A 1 163 ? -15.85995 0.73424   -24.91912 1.000 27.81964 ? 163 HIS A CG  1 
ATOM   1252 N  ND1 . HIS A 1 163 ? -15.24787 0.45462   -26.12192 1.000 30.23840 ? 163 HIS A ND1 1 
ATOM   1253 C  CD2 . HIS A 1 163 ? -16.16071 -0.46244  -24.36255 1.000 27.74699 ? 163 HIS A CD2 1 
ATOM   1254 C  CE1 . HIS A 1 163 ? -15.18223 -0.85439  -26.28606 1.000 30.83235 ? 163 HIS A CE1 1 
ATOM   1255 N  NE2 . HIS A 1 163 ? -15.72850 -1.43388  -25.23263 1.000 32.21671 ? 163 HIS A NE2 1 
ATOM   1256 N  N   . HIS A 1 164 ? -18.11187 1.93890   -27.12916 1.000 30.74954 ? 164 HIS A N   1 
ATOM   1257 C  CA  . HIS A 1 164 ? -19.35228 1.44042   -27.70900 1.000 27.14456 ? 164 HIS A CA  1 
ATOM   1258 C  C   . HIS A 1 164 ? -19.33908 -0.04616  -28.02468 1.000 35.85427 ? 164 HIS A C   1 
ATOM   1259 O  O   . HIS A 1 164 ? -20.36566 -0.70636  -27.85448 1.000 36.30868 ? 164 HIS A O   1 
ATOM   1260 C  CB  . HIS A 1 164 ? -19.68569 2.21664   -28.99170 1.000 26.44149 ? 164 HIS A CB  1 
ATOM   1261 C  CG  . HIS A 1 164 ? -20.28378 3.56651   -28.74557 1.000 25.81086 ? 164 HIS A CG  1 
ATOM   1262 N  ND1 . HIS A 1 164 ? -21.59820 3.86015   -29.03581 1.000 31.52976 ? 164 HIS A ND1 1 
ATOM   1263 C  CD2 . HIS A 1 164 ? -19.74849 4.70191   -28.23822 1.000 23.91546 ? 164 HIS A CD2 1 
ATOM   1264 C  CE1 . HIS A 1 164 ? -21.84726 5.11815   -28.71976 1.000 24.95453 ? 164 HIS A CE1 1 
ATOM   1265 N  NE2 . HIS A 1 164 ? -20.74159 5.65133   -28.23318 1.000 25.07033 ? 164 HIS A NE2 1 
ATOM   1266 N  N   . MET A 1 165 ? -18.21910 -0.60111  -28.48658 1.000 28.97500 ? 165 MET A N   1 
ATOM   1267 C  CA  . MET A 1 165 ? -18.26311 -1.95598  -29.02072 1.000 38.41524 ? 165 MET A CA  1 
ATOM   1268 C  C   . MET A 1 165 ? -16.86396 -2.54718  -29.10515 1.000 32.97955 ? 165 MET A C   1 
ATOM   1269 O  O   . MET A 1 165 ? -15.86265 -1.82869  -29.15766 1.000 29.22738 ? 165 MET A O   1 
ATOM   1270 C  CB  . MET A 1 165 ? -18.91969 -1.97477  -30.40418 1.000 30.29823 ? 165 MET A CB  1 
ATOM   1271 C  CG  . MET A 1 165 ? -18.15691 -1.17421  -31.44700 1.000 27.93043 ? 165 MET A CG  1 
ATOM   1272 S  SD  . MET A 1 165 ? -19.14087 -0.82777  -32.91963 1.000 43.35701 ? 165 MET A SD  1 
ATOM   1273 C  CE  . MET A 1 165 ? -19.97720 -2.39443  -33.11433 1.000 49.03519 ? 165 MET A CE  1 
ATOM   1274 N  N   . GLU A 1 166 ? -16.81886 -3.87686  -29.13317 1.000 32.41612 ? 166 GLU A N   1 
ATOM   1275 C  CA  . GLU A 1 166 ? -15.60504 -4.63334  -29.40795 1.000 30.45996 ? 166 GLU A CA  1 
ATOM   1276 C  C   . GLU A 1 166 ? -15.71903 -5.28492  -30.78018 1.000 39.53590 ? 166 GLU A C   1 
ATOM   1277 O  O   . GLU A 1 166 ? -16.71482 -5.95458  -31.07536 1.000 36.52179 ? 166 GLU A O   1 
ATOM   1278 C  CB  . GLU A 1 166 ? -15.35801 -5.69856  -28.33659 1.000 32.93781 ? 166 GLU A CB  1 
ATOM   1279 C  CG  . GLU A 1 166 ? -14.18226 -6.62261  -28.64667 1.000 40.01687 ? 166 GLU A CG  1 
ATOM   1280 C  CD  . GLU A 1 166 ? -13.76197 -7.47195  -27.45861 1.000 42.55319 ? 166 GLU A CD  1 
ATOM   1281 O  OE1 . GLU A 1 166 ? -13.53901 -6.90778  -26.36624 1.000 36.72809 ? 166 GLU A OE1 1 
ATOM   1282 O  OE2 . GLU A 1 166 ? -13.65539 -8.70628  -27.61770 1.000 41.77687 ? 166 GLU A OE2 1 
ATOM   1283 N  N   . LEU A 1 167 ? -14.70448 -5.08176  -31.61168 1.000 38.61511 ? 167 LEU A N   1 
ATOM   1284 C  CA  . LEU A 1 167 ? -14.66093 -5.66397  -32.94089 1.000 42.50176 ? 167 LEU A CA  1 
ATOM   1285 C  C   . LEU A 1 167 ? -14.18712 -7.11544  -32.86877 1.000 49.15763 ? 167 LEU A C   1 
ATOM   1286 O  O   . LEU A 1 167 ? -13.64924 -7.54957  -31.84700 1.000 45.99687 ? 167 LEU A O   1 
ATOM   1287 C  CB  . LEU A 1 167 ? -13.74657 -4.82771  -33.83237 1.000 41.88964 ? 167 LEU A CB  1 
ATOM   1288 C  CG  . LEU A 1 167 ? -14.25091 -3.40232  -34.08576 1.000 41.39821 ? 167 LEU A CG  1 
ATOM   1289 C  CD1 . LEU A 1 167 ? -13.18122 -2.55030  -34.74740 1.000 43.27733 ? 167 LEU A CD1 1 
ATOM   1290 C  CD2 . LEU A 1 167 ? -15.51556 -3.42227  -34.92799 1.000 37.89033 ? 167 LEU A CD2 1 
ATOM   1291 N  N   . PRO A 1 168 ? -14.39719 -7.89754  -33.93560 1.000 52.65972 ? 168 PRO A N   1 
ATOM   1292 C  CA  . PRO A 1 168 ? -14.01175 -9.32025  -33.88348 1.000 48.06412 ? 168 PRO A CA  1 
ATOM   1293 C  C   . PRO A 1 168 ? -12.54626 -9.56789  -33.56124 1.000 48.12834 ? 168 PRO A C   1 
ATOM   1294 O  O   . PRO A 1 168 ? -12.22406 -10.61423 -32.98542 1.000 48.62061 ? 168 PRO A O   1 
ATOM   1295 C  CB  . PRO A 1 168 ? -14.36963 -9.82356  -35.28746 1.000 51.05956 ? 168 PRO A CB  1 
ATOM   1296 C  CG  . PRO A 1 168 ? -15.49478 -8.95445  -35.70973 1.000 55.35391 ? 168 PRO A CG  1 
ATOM   1297 C  CD  . PRO A 1 168 ? -15.19448 -7.59367  -35.13930 1.000 52.88968 ? 168 PRO A CD  1 
ATOM   1298 N  N   . THR A 1 169 ? -11.64720 -8.64823  -33.90607 1.000 38.59872 ? 169 THR A N   1 
ATOM   1299 C  CA  . THR A 1 169 ? -10.22988 -8.84004  -33.62184 1.000 43.83668 ? 169 THR A CA  1 
ATOM   1300 C  C   . THR A 1 169 ? -9.86028  -8.55103  -32.17203 1.000 53.53231 ? 169 THR A C   1 
ATOM   1301 O  O   . THR A 1 169 ? -8.67225  -8.59628  -31.83588 1.000 49.20968 ? 169 THR A O   1 
ATOM   1302 C  CB  . THR A 1 169 ? -9.37898  -7.96228  -34.54223 1.000 50.67579 ? 169 THR A CB  1 
ATOM   1303 O  OG1 . THR A 1 169 ? -10.01698 -6.69029  -34.71779 1.000 51.56177 ? 169 THR A OG1 1 
ATOM   1304 C  CG2 . THR A 1 169 ? -9.18588  -8.63639  -35.89550 1.000 52.76309 ? 169 THR A CG2 1 
ATOM   1305 N  N   . GLY A 1 170 ? -10.83197 -8.26097  -31.30951 1.000 44.86612 ? 170 GLY A N   1 
ATOM   1306 C  CA  . GLY A 1 170 ? -10.55103 -7.93995  -29.92856 1.000 41.15815 ? 170 GLY A CA  1 
ATOM   1307 C  C   . GLY A 1 170 ? -10.22097 -6.48864  -29.66320 1.000 38.98414 ? 170 GLY A C   1 
ATOM   1308 O  O   . GLY A 1 170 ? -9.96883  -6.13173  -28.50523 1.000 39.71222 ? 170 GLY A O   1 
ATOM   1309 N  N   . VAL A 1 171 ? -10.20684 -5.64605  -30.68871 1.000 36.11437 ? 171 VAL A N   1 
ATOM   1310 C  CA  . VAL A 1 171 ? -9.95701  -4.22946  -30.52298 1.000 38.23683 ? 171 VAL A CA  1 
ATOM   1311 C  C   . VAL A 1 171 ? -11.29693 -3.50916  -30.38813 1.000 36.13355 ? 171 VAL A C   1 
ATOM   1312 O  O   . VAL A 1 171 ? -12.36020 -4.08714  -30.59117 1.000 36.20285 ? 171 VAL A O   1 
ATOM   1313 C  CB  . VAL A 1 171 ? -9.11111  -3.65061  -31.68256 1.000 39.11475 ? 171 VAL A CB  1 
ATOM   1314 C  CG1 . VAL A 1 171 ? -7.78860  -4.39375  -31.78767 1.000 40.68824 ? 171 VAL A CG1 1 
ATOM   1315 C  CG2 . VAL A 1 171 ? -9.87758  -3.72158  -32.99221 1.000 32.22636 ? 171 VAL A CG2 1 
ATOM   1316 N  N   . HIS A 1 172 ? -11.24253 -2.22547  -30.04798 1.000 33.19484 ? 172 HIS A N   1 
ATOM   1317 C  CA  . HIS A 1 172 ? -12.41779 -1.51573  -29.56574 1.000 31.15549 ? 172 HIS A CA  1 
ATOM   1318 C  C   . HIS A 1 172 ? -12.66321 -0.24868  -30.37165 1.000 33.20544 ? 172 HIS A C   1 
ATOM   1319 O  O   . HIS A 1 172 ? -11.71991 0.42207   -30.80224 1.000 28.69147 ? 172 HIS A O   1 
ATOM   1320 C  CB  . HIS A 1 172 ? -12.25856 -1.18943  -28.07857 1.000 31.63112 ? 172 HIS A CB  1 
ATOM   1321 C  CG  . HIS A 1 172 ? -11.93431 -2.38725  -27.24075 1.000 31.32307 ? 172 HIS A CG  1 
ATOM   1322 N  ND1 . HIS A 1 172 ? -10.66464 -2.64824  -26.77290 1.000 31.21206 ? 172 HIS A ND1 1 
ATOM   1323 C  CD2 . HIS A 1 172 ? -12.70951 -3.41269  -26.81526 1.000 30.35682 ? 172 HIS A CD2 1 
ATOM   1324 C  CE1 . HIS A 1 172 ? -10.67490 -3.77350  -26.08105 1.000 31.99466 ? 172 HIS A CE1 1 
ATOM   1325 N  NE2 . HIS A 1 172 ? -11.90353 -4.25769  -26.09202 1.000 30.25929 ? 172 HIS A NE2 1 
ATOM   1326 N  N   . ALA A 1 173 ? -13.94339 0.06930   -30.56718 1.000 25.14913 ? 173 ALA A N   1 
ATOM   1327 C  CA  . ALA A 1 173 ? -14.37196 1.23400   -31.32359 1.000 28.76677 ? 173 ALA A CA  1 
ATOM   1328 C  C   . ALA A 1 173 ? -15.35411 2.04719   -30.49317 1.000 27.45805 ? 173 ALA A C   1 
ATOM   1329 O  O   . ALA A 1 173 ? -16.08880 1.50673   -29.66154 1.000 27.78127 ? 173 ALA A O   1 
ATOM   1330 C  CB  . ALA A 1 173 ? -15.01987 0.83180   -32.65785 1.000 31.18699 ? 173 ALA A CB  1 
ATOM   1331 N  N   . GLY A 1 174 ? -15.36074 3.35294   -30.72548 1.000 26.70209 ? 174 GLY A N   1 
ATOM   1332 C  CA  . GLY A 1 174 ? -16.21489 4.22754   -29.95968 1.000 23.30885 ? 174 GLY A CA  1 
ATOM   1333 C  C   . GLY A 1 174 ? -16.37935 5.57354   -30.62792 1.000 28.62441 ? 174 GLY A C   1 
ATOM   1334 O  O   . GLY A 1 174 ? -16.01206 5.76455   -31.78988 1.000 29.48492 ? 174 GLY A O   1 
ATOM   1335 N  N   . THR A 1 175 ? -16.93801 6.51135   -29.86653 1.000 26.32254 ? 175 THR A N   1 
ATOM   1336 C  CA  . THR A 1 175 ? -17.29304 7.83172   -30.36130 1.000 29.33114 ? 175 THR A CA  1 
ATOM   1337 C  C   . THR A 1 175 ? -16.67774 8.89481   -29.46619 1.000 28.75500 ? 175 THR A C   1 
ATOM   1338 O  O   . THR A 1 175 ? -16.21279 8.61441   -28.35876 1.000 28.71243 ? 175 THR A O   1 
ATOM   1339 C  CB  . THR A 1 175 ? -18.81566 8.02907   -30.39804 1.000 27.92319 ? 175 THR A CB  1 
ATOM   1340 O  OG1 . THR A 1 175 ? -19.31320 8.13123   -29.05642 1.000 29.52084 ? 175 THR A OG1 1 
ATOM   1341 C  CG2 . THR A 1 175 ? -19.49411 6.86324   -31.08641 1.000 28.49717 ? 175 THR A CG2 1 
ATOM   1342 N  N   . ASP A 1 176 ? -16.69052 10.13336  -29.95335 1.000 35.56891 ? 176 ASP A N   1 
ATOM   1343 C  CA  . ASP A 1 176 ? -16.44755 11.26354  -29.07426 1.000 33.16610 ? 176 ASP A CA  1 
ATOM   1344 C  C   . ASP A 1 176 ? -17.70930 11.53403  -28.25697 1.000 30.75011 ? 176 ASP A C   1 
ATOM   1345 O  O   . ASP A 1 176 ? -18.72673 10.84471  -28.38775 1.000 28.96478 ? 176 ASP A O   1 
ATOM   1346 C  CB  . ASP A 1 176 ? -15.99691 12.48900  -29.87374 1.000 33.79157 ? 176 ASP A CB  1 
ATOM   1347 C  CG  . ASP A 1 176 ? -16.98989 12.90450  -30.95436 1.000 35.02338 ? 176 ASP A CG  1 
ATOM   1348 O  OD1 . ASP A 1 176 ? -18.20061 12.62426  -30.82986 1.000 31.89119 ? 176 ASP A OD1 1 
ATOM   1349 O  OD2 . ASP A 1 176 ? -16.54450 13.52027  -31.94744 1.000 39.14823 ? 176 ASP A OD2 1 
ATOM   1350 N  N   . LEU A 1 177 ? -17.65664 12.54751  -27.40097 1.000 29.90981 ? 177 LEU A N   1 
ATOM   1351 C  CA  . LEU A 1 177 ? -18.80745 12.84461  -26.55747 1.000 36.11630 ? 177 LEU A CA  1 
ATOM   1352 C  C   . LEU A 1 177 ? -19.87558 13.64685  -27.28911 1.000 39.19805 ? 177 LEU A C   1 
ATOM   1353 O  O   . LEU A 1 177 ? -20.85181 14.08004  -26.66480 1.000 37.55312 ? 177 LEU A O   1 
ATOM   1354 C  CB  . LEU A 1 177 ? -18.36211 13.56527  -25.28292 1.000 30.16414 ? 177 LEU A CB  1 
ATOM   1355 C  CG  . LEU A 1 177 ? -18.08035 12.62710  -24.10134 1.000 35.14646 ? 177 LEU A CG  1 
ATOM   1356 C  CD1 . LEU A 1 177 ? -19.36383 11.95236  -23.62550 1.000 33.34098 ? 177 LEU A CD1 1 
ATOM   1357 C  CD2 . LEU A 1 177 ? -17.02805 11.57733  -24.44887 1.000 29.55099 ? 177 LEU A CD2 1 
ATOM   1358 N  N   . GLU A 1 178 ? -19.70978 13.84561  -28.59483 1.000 31.33654 ? 178 GLU A N   1 
ATOM   1359 C  CA  . GLU A 1 178 ? -20.77317 14.32893  -29.46044 1.000 37.74807 ? 178 GLU A CA  1 
ATOM   1360 C  C   . GLU A 1 178 ? -21.36478 13.21270  -30.31201 1.000 37.78934 ? 178 GLU A C   1 
ATOM   1361 O  O   . GLU A 1 178 ? -22.10057 13.49254  -31.26374 1.000 35.55791 ? 178 GLU A O   1 
ATOM   1362 C  CB  . GLU A 1 178 ? -20.26123 15.46669  -30.34566 1.000 41.21522 ? 178 GLU A CB  1 
ATOM   1363 C  CG  . GLU A 1 178 ? -19.84574 16.70327  -29.56005 1.000 41.99300 ? 178 GLU A CG  1 
ATOM   1364 C  CD  . GLU A 1 178 ? -19.59177 17.90885  -30.44505 1.000 58.35724 ? 178 GLU A CD  1 
ATOM   1365 O  OE1 . GLU A 1 178 ? -18.87001 17.77155  -31.45567 1.000 58.42437 ? 178 GLU A OE1 1 
ATOM   1366 O  OE2 . GLU A 1 178 ? -20.12141 18.99586  -30.12989 1.000 65.55571 ? 178 GLU A OE2 1 
ATOM   1367 N  N   . GLY A 1 179 ? -21.05048 11.95660  -29.99526 1.000 30.17125 ? 179 GLY A N   1 
ATOM   1368 C  CA  . GLY A 1 179 ? -21.67343 10.82103  -30.64274 1.000 34.87860 ? 179 GLY A CA  1 
ATOM   1369 C  C   . GLY A 1 179 ? -21.11777 10.44592  -31.99509 1.000 35.97781 ? 179 GLY A C   1 
ATOM   1370 O  O   . GLY A 1 179 ? -21.68656 9.56878   -32.65490 1.000 35.09093 ? 179 GLY A O   1 
ATOM   1371 N  N   . ASN A 1 180 ? -20.03053 11.07291  -32.43221 1.000 33.71914 ? 180 ASN A N   1 
ATOM   1372 C  CA  . ASN A 1 180 ? -19.44128 10.78262  -33.73203 1.000 31.59673 ? 180 ASN A CA  1 
ATOM   1373 C  C   . ASN A 1 180 ? -18.37582 9.70537   -33.57744 1.000 36.50250 ? 180 ASN A C   1 
ATOM   1374 O  O   . ASN A 1 180 ? -17.40655 9.88469   -32.83127 1.000 36.37056 ? 180 ASN A O   1 
ATOM   1375 C  CB  . ASN A 1 180 ? -18.85164 12.04784  -34.34878 1.000 32.50231 ? 180 ASN A CB  1 
ATOM   1376 C  CG  . ASN A 1 180 ? -19.91809 12.98311  -34.87038 1.000 33.42663 ? 180 ASN A CG  1 
ATOM   1377 O  OD1 . ASN A 1 180 ? -20.77132 12.58565  -35.66470 1.000 35.22369 ? 180 ASN A OD1 1 
ATOM   1378 N  ND2 . ASN A 1 180 ? -19.88987 14.22811  -34.41192 1.000 39.50158 ? 180 ASN A ND2 1 
ATOM   1379 N  N   . PHE A 1 181 ? -18.55911 8.59228   -34.28452 1.000 39.57151 ? 181 PHE A N   1 
ATOM   1380 C  CA  . PHE A 1 181 ? -17.61573 7.48612   -34.21361 1.000 34.20151 ? 181 PHE A CA  1 
ATOM   1381 C  C   . PHE A 1 181 ? -16.23831 7.90853   -34.70862 1.000 33.84849 ? 181 PHE A C   1 
ATOM   1382 O  O   . PHE A 1 181 ? -16.10145 8.72168   -35.62640 1.000 33.21121 ? 181 PHE A O   1 
ATOM   1383 C  CB  . PHE A 1 181 ? -18.11538 6.30384   -35.04945 1.000 31.08716 ? 181 PHE A CB  1 
ATOM   1384 C  CG  . PHE A 1 181 ? -18.75347 5.20969   -34.24316 1.000 33.11804 ? 181 PHE A CG  1 
ATOM   1385 C  CD1 . PHE A 1 181 ? -20.12012 5.20477   -34.01644 1.000 34.63818 ? 181 PHE A CD1 1 
ATOM   1386 C  CD2 . PHE A 1 181 ? -17.98806 4.17885   -33.72173 1.000 32.21877 ? 181 PHE A CD2 1 
ATOM   1387 C  CE1 . PHE A 1 181 ? -20.70972 4.19879   -33.27251 1.000 31.59841 ? 181 PHE A CE1 1 
ATOM   1388 C  CE2 . PHE A 1 181 ? -18.57286 3.16579   -32.98106 1.000 30.00151 ? 181 PHE A CE2 1 
ATOM   1389 C  CZ  . PHE A 1 181 ? -19.93663 3.17719   -32.75587 1.000 24.32740 ? 181 PHE A CZ  1 
ATOM   1390 N  N   . TYR A 1 182 ? -15.20956 7.34842   -34.08067 1.000 29.50578 ? 182 TYR A N   1 
ATOM   1391 C  CA  . TYR A 1 182 ? -13.86415 7.40756   -34.63127 1.000 27.00404 ? 182 TYR A CA  1 
ATOM   1392 C  C   . TYR A 1 182 ? -13.73242 6.31342   -35.68297 1.000 29.00446 ? 182 TYR A C   1 
ATOM   1393 O  O   . TYR A 1 182 ? -13.91755 5.13019   -35.37968 1.000 33.66373 ? 182 TYR A O   1 
ATOM   1394 C  CB  . TYR A 1 182 ? -12.81435 7.23574   -33.53242 1.000 28.42270 ? 182 TYR A CB  1 
ATOM   1395 C  CG  . TYR A 1 182 ? -12.69939 8.41209   -32.58402 1.000 32.98521 ? 182 TYR A CG  1 
ATOM   1396 C  CD1 . TYR A 1 182 ? -11.95135 9.53115   -32.92385 1.000 30.37999 ? 182 TYR A CD1 1 
ATOM   1397 C  CD2 . TYR A 1 182 ? -13.33128 8.39964   -31.34575 1.000 28.31473 ? 182 TYR A CD2 1 
ATOM   1398 C  CE1 . TYR A 1 182 ? -11.84046 10.60672  -32.06350 1.000 26.80719 ? 182 TYR A CE1 1 
ATOM   1399 C  CE2 . TYR A 1 182 ? -13.22592 9.47187   -30.47803 1.000 27.91018 ? 182 TYR A CE2 1 
ATOM   1400 C  CZ  . TYR A 1 182 ? -12.47876 10.57381  -30.84269 1.000 34.34209 ? 182 TYR A CZ  1 
ATOM   1401 O  OH  . TYR A 1 182 ? -12.36708 11.64621  -29.98553 1.000 29.80987 ? 182 TYR A OH  1 
ATOM   1402 N  N   . GLY A 1 183 ? -13.43388 6.70301   -36.91810 1.000 32.07152 ? 183 GLY A N   1 
ATOM   1403 C  CA  . GLY A 1 183 ? -13.29025 5.75102   -37.99241 1.000 30.97397 ? 183 GLY A CA  1 
ATOM   1404 C  C   . GLY A 1 183 ? -14.59392 5.46299   -38.70660 1.000 34.98103 ? 183 GLY A C   1 
ATOM   1405 O  O   . GLY A 1 183 ? -15.61033 6.13046   -38.49441 1.000 34.64196 ? 183 GLY A O   1 
ATOM   1406 N  N   . PRO A 1 184 ? -14.58597 4.44920   -39.57160 1.000 39.61814 ? 184 PRO A N   1 
ATOM   1407 C  CA  . PRO A 1 184 ? -15.76193 4.17850   -40.40702 1.000 41.09370 ? 184 PRO A CA  1 
ATOM   1408 C  C   . PRO A 1 184 ? -16.73760 3.20759   -39.76514 1.000 33.96038 ? 184 PRO A C   1 
ATOM   1409 O  O   . PRO A 1 184 ? -17.44124 2.47917   -40.47020 1.000 41.16960 ? 184 PRO A O   1 
ATOM   1410 C  CB  . PRO A 1 184 ? -15.14034 3.57978   -41.67267 1.000 34.56000 ? 184 PRO A CB  1 
ATOM   1411 C  CG  . PRO A 1 184 ? -13.95852 2.81601   -41.13920 1.000 34.51811 ? 184 PRO A CG  1 
ATOM   1412 C  CD  . PRO A 1 184 ? -13.44433 3.59051   -39.93674 1.000 40.08770 ? 184 PRO A CD  1 
ATOM   1413 N  N   . PHE A 1 185 ? -16.79190 3.18028   -38.44030 1.000 37.71962 ? 185 PHE A N   1 
ATOM   1414 C  CA  . PHE A 1 185 ? -17.58452 2.17355   -37.75323 1.000 37.17475 ? 185 PHE A CA  1 
ATOM   1415 C  C   . PHE A 1 185 ? -18.96223 2.71689   -37.38740 1.000 36.15695 ? 185 PHE A C   1 
ATOM   1416 O  O   . PHE A 1 185 ? -19.17318 3.92567   -37.26951 1.000 35.15485 ? 185 PHE A O   1 
ATOM   1417 C  CB  . PHE A 1 185 ? -16.84955 1.67366   -36.50573 1.000 35.41624 ? 185 PHE A CB  1 
ATOM   1418 C  CG  . PHE A 1 185 ? -15.42317 1.28042   -36.76945 1.000 35.13682 ? 185 PHE A CG  1 
ATOM   1419 C  CD1 . PHE A 1 185 ? -15.12502 0.11364   -37.45957 1.000 38.84664 ? 185 PHE A CD1 1 
ATOM   1420 C  CD2 . PHE A 1 185 ? -14.38117 2.08614   -36.34543 1.000 35.89480 ? 185 PHE A CD2 1 
ATOM   1421 C  CE1 . PHE A 1 185 ? -13.81165 -0.24320  -37.71467 1.000 41.03212 ? 185 PHE A CE1 1 
ATOM   1422 C  CE2 . PHE A 1 185 ? -13.06484 1.73358   -36.59639 1.000 37.98493 ? 185 PHE A CE2 1 
ATOM   1423 C  CZ  . PHE A 1 185 ? -12.78051 0.56859   -37.28120 1.000 31.88394 ? 185 PHE A CZ  1 
ATOM   1424 N  N   . VAL A 1 186 ? -19.90962 1.79427   -37.22577 1.000 34.01934 ? 186 VAL A N   1 
ATOM   1425 C  CA  . VAL A 1 186 ? -21.29397 2.11646   -36.90864 1.000 36.57377 ? 186 VAL A CA  1 
ATOM   1426 C  C   . VAL A 1 186 ? -21.74263 1.22940   -35.75688 1.000 37.63180 ? 186 VAL A C   1 
ATOM   1427 O  O   . VAL A 1 186 ? -21.23095 0.12047   -35.57038 1.000 35.18110 ? 186 VAL A O   1 
ATOM   1428 C  CB  . VAL A 1 186 ? -22.22214 1.93292   -38.13323 1.000 32.39331 ? 186 VAL A CB  1 
ATOM   1429 C  CG1 . VAL A 1 186 ? -21.82447 2.88176   -39.25287 1.000 25.33307 ? 186 VAL A CG1 1 
ATOM   1430 C  CG2 . VAL A 1 186 ? -22.18052 0.49240   -38.62258 1.000 35.38090 ? 186 VAL A CG2 1 
ATOM   1431 N  N   . ASP A 1 187 ? -22.70833 1.72179   -34.97535 1.000 35.11639 ? 187 ASP A N   1 
ATOM   1432 C  CA  . ASP A 1 187 ? -23.27128 0.92924   -33.87961 1.000 33.00236 ? 187 ASP A CA  1 
ATOM   1433 C  C   . ASP A 1 187 ? -24.32045 -0.02893  -34.45039 1.000 36.44260 ? 187 ASP A C   1 
ATOM   1434 O  O   . ASP A 1 187 ? -25.52663 0.08127   -34.21676 1.000 31.72234 ? 187 ASP A O   1 
ATOM   1435 C  CB  . ASP A 1 187 ? -23.83357 1.82284   -32.77933 1.000 33.12012 ? 187 ASP A CB  1 
ATOM   1436 C  CG  . ASP A 1 187 ? -24.70660 2.94661   -33.30906 1.000 35.54991 ? 187 ASP A CG  1 
ATOM   1437 O  OD1 . ASP A 1 187 ? -24.96508 2.98809   -34.52680 1.000 38.34095 ? 187 ASP A OD1 1 
ATOM   1438 O  OD2 . ASP A 1 187 ? -25.13184 3.79738   -32.49612 1.000 38.07456 ? 187 ASP A OD2 1 
ATOM   1439 N  N   . ARG A 1 188 ? -23.81922 -0.98863  -35.22696 1.000 32.28018 ? 188 ARG A N   1 
ATOM   1440 C  CA  . ARG A 1 188 ? -24.61199 -2.02923  -35.86402 1.000 43.21177 ? 188 ARG A CA  1 
ATOM   1441 C  C   . ARG A 1 188 ? -23.86470 -3.34717  -35.74217 1.000 42.72120 ? 188 ARG A C   1 
ATOM   1442 O  O   . ARG A 1 188 ? -22.63644 -3.38239  -35.85876 1.000 39.34410 ? 188 ARG A O   1 
ATOM   1443 C  CB  . ARG A 1 188 ? -24.86796 -1.72906  -37.34769 1.000 40.80833 ? 188 ARG A CB  1 
ATOM   1444 C  CG  . ARG A 1 188 ? -26.12199 -0.94795  -37.63880 1.000 34.45006 ? 188 ARG A CG  1 
ATOM   1445 C  CD  . ARG A 1 188 ? -26.69246 -1.35615  -38.98862 1.000 34.21493 ? 188 ARG A CD  1 
ATOM   1446 N  NE  . ARG A 1 188 ? -25.86773 -0.88582  -40.09295 1.000 48.29789 ? 188 ARG A NE  1 
ATOM   1447 C  CZ  . ARG A 1 188 ? -25.83746 -1.43863  -41.29734 1.000 43.59958 ? 188 ARG A CZ  1 
ATOM   1448 N  NH1 . ARG A 1 188 ? -26.55186 -2.51480  -41.58204 1.000 37.47286 ? 188 ARG A NH1 1 
ATOM   1449 N  NH2 . ARG A 1 188 ? -25.06172 -0.90377  -42.23613 1.000 49.23436 ? 188 ARG A NH2 1 
ATOM   1450 N  N   . GLN A 1 189 ? -24.60663 -4.43125  -35.52888 1.000 43.42278 ? 189 GLN A N   1 
ATOM   1451 C  CA  . GLN A 1 189 ? -24.00387 -5.74822  -35.37024 1.000 51.12977 ? 189 GLN A CA  1 
ATOM   1452 C  C   . GLN A 1 189 ? -23.64863 -6.40864  -36.70328 1.000 50.93544 ? 189 GLN A C   1 
ATOM   1453 O  O   . GLN A 1 189 ? -23.41400 -7.62191  -36.73584 1.000 57.22578 ? 189 GLN A O   1 
ATOM   1454 C  CB  . GLN A 1 189 ? -24.93308 -6.65356  -34.55477 1.000 54.38231 ? 189 GLN A CB  1 
ATOM   1455 C  CG  . GLN A 1 189 ? -24.20379 -7.68745  -33.70528 1.000 60.28070 ? 189 GLN A CG  1 
ATOM   1456 C  CD  . GLN A 1 189 ? -25.03212 -8.18314  -32.53390 1.000 73.19414 ? 189 GLN A CD  1 
ATOM   1457 O  OE1 . GLN A 1 189 ? -25.95103 -8.98492  -32.70065 1.000 76.34698 ? 189 GLN A OE1 1 
ATOM   1458 N  NE2 . GLN A 1 189 ? -24.70600 -7.70678  -31.33705 1.000 70.19201 ? 189 GLN A NE2 1 
ATOM   1459 N  N   . THR A 1 190 ? -23.59835 -5.65022  -37.79596 1.000 49.24497 ? 190 THR A N   1 
ATOM   1460 C  CA  . THR A 1 190 ? -23.20270 -6.20833  -39.07919 1.000 51.25914 ? 190 THR A CA  1 
ATOM   1461 C  C   . THR A 1 190 ? -21.68326 -6.34805  -39.14308 1.000 49.86234 ? 190 THR A C   1 
ATOM   1462 O  O   . THR A 1 190 ? -20.95583 -5.95438  -38.22782 1.000 51.93584 ? 190 THR A O   1 
ATOM   1463 C  CB  . THR A 1 190 ? -23.72498 -5.34681  -40.22808 1.000 56.48759 ? 190 THR A CB  1 
ATOM   1464 O  OG1 . THR A 1 190 ? -23.23773 -4.00523  -40.08733 1.000 55.06631 ? 190 THR A OG1 1 
ATOM   1465 C  CG2 . THR A 1 190 ? -25.24965 -5.34116  -40.23893 1.000 56.06257 ? 190 THR A CG2 1 
ATOM   1466 N  N   . ALA A 1 191 ? -21.19820 -6.91805  -40.24434 1.000 52.21328 ? 191 ALA A N   1 
ATOM   1467 C  CA  . ALA A 1 191 ? -19.77508 -7.19857  -40.39424 1.000 49.15786 ? 191 ALA A CA  1 
ATOM   1468 C  C   . ALA A 1 191 ? -18.98077 -5.90095  -40.46418 1.000 53.08213 ? 191 ALA A C   1 
ATOM   1469 O  O   . ALA A 1 191 ? -19.18078 -5.08768  -41.37298 1.000 50.98696 ? 191 ALA A O   1 
ATOM   1470 C  CB  . ALA A 1 191 ? -19.53043 -8.03971  -41.64396 1.000 45.47104 ? 191 ALA A CB  1 
ATOM   1471 N  N   . GLN A 1 192 ? -18.07760 -5.71250  -39.50424 1.000 54.19740 ? 192 GLN A N   1 
ATOM   1472 C  CA  . GLN A 1 192 ? -17.18020 -4.56591  -39.47683 1.000 48.02331 ? 192 GLN A CA  1 
ATOM   1473 C  C   . GLN A 1 192 ? -15.78188 -5.05599  -39.14112 1.000 55.51488 ? 192 GLN A C   1 
ATOM   1474 O  O   . GLN A 1 192 ? -15.60828 -5.84699  -38.20873 1.000 55.00193 ? 192 GLN A O   1 
ATOM   1475 C  CB  . GLN A 1 192 ? -17.62935 -3.52077  -38.44914 1.000 42.55355 ? 192 GLN A CB  1 
ATOM   1476 C  CG  . GLN A 1 192 ? -18.94646 -2.84002  -38.76774 1.000 48.10259 ? 192 GLN A CG  1 
ATOM   1477 C  CD  . GLN A 1 192 ? -19.34880 -1.84005  -37.70248 1.000 45.24139 ? 192 GLN A CD  1 
ATOM   1478 O  OE1 . GLN A 1 192 ? -19.05199 -0.65039  -37.80685 1.000 43.26543 ? 192 GLN A OE1 1 
ATOM   1479 N  NE2 . GLN A 1 192 ? -20.02618 -2.32116  -36.66602 1.000 40.10686 ? 192 GLN A NE2 1 
ATOM   1480 N  N   . ALA A 1 193 ? -14.79133 -4.58637  -39.89617 1.000 42.35795 ? 193 ALA A N   1 
ATOM   1481 C  CA  . ALA A 1 193 ? -13.40516 -4.97296  -39.67489 1.000 55.91707 ? 193 ALA A CA  1 
ATOM   1482 C  C   . ALA A 1 193 ? -12.52527 -3.73698  -39.74158 1.000 48.18855 ? 193 ALA A C   1 
ATOM   1483 O  O   . ALA A 1 193 ? -12.64444 -2.93673  -40.67396 1.000 45.22399 ? 193 ALA A O   1 
ATOM   1484 C  CB  . ALA A 1 193 ? -12.94115 -6.00689  -40.70777 1.000 53.88224 ? 193 ALA A CB  1 
ATOM   1485 N  N   . ALA A 1 194 ? -11.64832 -3.58465  -38.75528 1.000 43.94915 ? 194 ALA A N   1 
ATOM   1486 C  CA  . ALA A 1 194 ? -10.70910 -2.47396  -38.76284 1.000 42.74081 ? 194 ALA A CA  1 
ATOM   1487 C  C   . ALA A 1 194 ? -9.66449  -2.67511  -39.85258 1.000 43.82499 ? 194 ALA A C   1 
ATOM   1488 O  O   . ALA A 1 194 ? -9.25243  -3.80301  -40.13991 1.000 40.08944 ? 194 ALA A O   1 
ATOM   1489 C  CB  . ALA A 1 194 ? -10.02808 -2.34614  -37.40316 1.000 42.66600 ? 194 ALA A CB  1 
ATOM   1490 N  N   . GLY A 1 195 ? -9.23959  -1.57266  -40.46579 1.000 45.80590 ? 195 GLY A N   1 
ATOM   1491 C  CA  . GLY A 1 195 ? -8.18575  -1.62904  -41.45795 1.000 38.87879 ? 195 GLY A CA  1 
ATOM   1492 C  C   . GLY A 1 195 ? -6.86198  -2.05528  -40.85760 1.000 52.00753 ? 195 GLY A C   1 
ATOM   1493 O  O   . GLY A 1 195 ? -6.75382  -2.23159  -39.63864 1.000 43.22290 ? 195 GLY A O   1 
ATOM   1494 N  N   . THR A 1 196 ? -5.84692  -2.23114  -41.69937 1.000 52.84376 ? 196 THR A N   1 
ATOM   1495 C  CA  . THR A 1 196 ? -4.54266  -2.63906  -41.19795 1.000 49.81830 ? 196 THR A CA  1 
ATOM   1496 C  C   . THR A 1 196 ? -3.99499  -1.58195  -40.24496 1.000 37.89945 ? 196 THR A C   1 
ATOM   1497 O  O   . THR A 1 196 ? -4.01559  -0.38356  -40.54219 1.000 48.06741 ? 196 THR A O   1 
ATOM   1498 C  CB  . THR A 1 196 ? -3.57206  -2.88258  -42.35948 1.000 47.11577 ? 196 THR A CB  1 
ATOM   1499 O  OG1 . THR A 1 196 ? -2.28089  -3.22754  -41.84120 1.000 53.60434 ? 196 THR A OG1 1 
ATOM   1500 C  CG2 . THR A 1 196 ? -3.44579  -1.64658  -43.24999 1.000 49.99016 ? 196 THR A CG2 1 
ATOM   1501 N  N   . ASP A 1 197 ? -3.53847  -2.02366  -39.07852 1.000 37.04313 ? 197 ASP A N   1 
ATOM   1502 C  CA  . ASP A 1 197 ? -2.99678  -1.09232  -38.10339 1.000 41.03212 ? 197 ASP A CA  1 
ATOM   1503 C  C   . ASP A 1 197 ? -1.53435  -0.79704  -38.41434 1.000 42.54341 ? 197 ASP A C   1 
ATOM   1504 O  O   . ASP A 1 197 ? -0.81600  -1.62358  -38.98441 1.000 41.48713 ? 197 ASP A O   1 
ATOM   1505 C  CB  . ASP A 1 197 ? -3.13171  -1.64515  -36.68440 1.000 36.75300 ? 197 ASP A CB  1 
ATOM   1506 C  CG  . ASP A 1 197 ? -2.95573  -0.57121  -35.62345 1.000 44.08372 ? 197 ASP A CG  1 
ATOM   1507 O  OD1 . ASP A 1 197 ? -3.13026  0.62261   -35.95296 1.000 43.99898 ? 197 ASP A OD1 1 
ATOM   1508 O  OD2 . ASP A 1 197 ? -2.63529  -0.91470  -34.46544 1.000 42.35335 ? 197 ASP A OD2 1 
ATOM   1509 N  N   . THR A 1 198 ? -1.10049  0.40285   -38.04189 1.000 38.82761 ? 198 THR A N   1 
ATOM   1510 C  CA  . THR A 1 198 ? 0.25248   0.86052   -38.30797 1.000 33.33182 ? 198 THR A CA  1 
ATOM   1511 C  C   . THR A 1 198 ? 0.85750   1.44212   -37.03769 1.000 35.05984 ? 198 THR A C   1 
ATOM   1512 O  O   . THR A 1 198 ? 0.15030   1.79241   -36.08871 1.000 32.16925 ? 198 THR A O   1 
ATOM   1513 C  CB  . THR A 1 198 ? 0.27712   1.90533   -39.42688 1.000 40.57929 ? 198 THR A CB  1 
ATOM   1514 O  OG1 . THR A 1 198 ? -0.71331  2.90461   -39.16110 1.000 34.82308 ? 198 THR A OG1 1 
ATOM   1515 C  CG2 . THR A 1 198 ? -0.01276  1.25631   -40.76788 1.000 35.38775 ? 198 THR A CG2 1 
ATOM   1516 N  N   . THR A 1 199 ? 2.18446   1.53651   -37.03220 1.000 30.64942 ? 199 THR A N   1 
ATOM   1517 C  CA  . THR A 1 199 ? 2.90429   2.10044   -35.90064 1.000 27.01258 ? 199 THR A CA  1 
ATOM   1518 C  C   . THR A 1 199 ? 2.92323   3.62054   -35.99451 1.000 26.34520 ? 199 THR A C   1 
ATOM   1519 O  O   . THR A 1 199 ? 3.11082   4.19028   -37.07417 1.000 31.07219 ? 199 THR A O   1 
ATOM   1520 C  CB  . THR A 1 199 ? 4.33371   1.55881   -35.85126 1.000 31.87015 ? 199 THR A CB  1 
ATOM   1521 O  OG1 . THR A 1 199 ? 4.30374   0.12739   -35.88808 1.000 36.05632 ? 199 THR A OG1 1 
ATOM   1522 C  CG2 . THR A 1 199 ? 5.02970   2.00027   -34.57319 1.000 23.20508 ? 199 THR A CG2 1 
ATOM   1523 N  N   . ILE A 1 200 ? 2.71924   4.27581   -34.85321 1.000 30.51505 ? 200 ILE A N   1 
ATOM   1524 C  CA  . ILE A 1 200 ? 2.67412   5.73226   -34.79791 1.000 28.88039 ? 200 ILE A CA  1 
ATOM   1525 C  C   . ILE A 1 200 ? 4.10544   6.25119   -34.76169 1.000 36.92084 ? 200 ILE A C   1 
ATOM   1526 O  O   . ILE A 1 200 ? 4.72183   6.34408   -33.69201 1.000 31.13369 ? 200 ILE A O   1 
ATOM   1527 C  CB  . ILE A 1 200 ? 1.86324   6.21585   -33.58280 1.000 29.31271 ? 200 ILE A CB  1 
ATOM   1528 C  CG1 . ILE A 1 200 ? 0.50320   5.49847   -33.54532 1.000 26.73877 ? 200 ILE A CG1 1 
ATOM   1529 C  CG2 . ILE A 1 200 ? 1.67639   7.72411   -33.63274 1.000 22.47922 ? 200 ILE A CG2 1 
ATOM   1530 C  CD1 . ILE A 1 200 ? -0.18839  5.56238   -32.19463 1.000 31.07901 ? 200 ILE A CD1 1 
ATOM   1531 N  N   . THR A 1 201 ? 4.63493   6.60384   -35.93544 1.000 27.78225 ? 201 THR A N   1 
ATOM   1532 C  CA  . THR A 1 201 ? 6.06347   6.87850   -36.06903 1.000 31.35862 ? 201 THR A CA  1 
ATOM   1533 C  C   . THR A 1 201 ? 6.49529   8.06288   -35.21207 1.000 26.21399 ? 201 THR A C   1 
ATOM   1534 O  O   . THR A 1 201 ? 7.51252   7.99572   -34.51297 1.000 30.12561 ? 201 THR A O   1 
ATOM   1535 C  CB  . THR A 1 201 ? 6.40948   7.12729   -37.53595 1.000 29.07954 ? 201 THR A CB  1 
ATOM   1536 O  OG1 . THR A 1 201 ? 6.02562   5.98767   -38.31419 1.000 31.85494 ? 201 THR A OG1 1 
ATOM   1537 C  CG2 . THR A 1 201 ? 7.89865   7.36141   -37.69093 1.000 25.49535 ? 201 THR A CG2 1 
ATOM   1538 N  N   . VAL A 1 202 ? 5.73717   9.16220   -35.25576 1.000 27.79913 ? 202 VAL A N   1 
ATOM   1539 C  CA  . VAL A 1 202 ? 6.11496   10.34624  -34.48683 1.000 26.27966 ? 202 VAL A CA  1 
ATOM   1540 C  C   . VAL A 1 202 ? 6.18080   10.02910  -32.99956 1.000 29.70261 ? 202 VAL A C   1 
ATOM   1541 O  O   . VAL A 1 202 ? 6.98167   10.62233  -32.26576 1.000 29.65183 ? 202 VAL A O   1 
ATOM   1542 C  CB  . VAL A 1 202 ? 5.14837   11.51407  -34.77879 1.000 30.52857 ? 202 VAL A CB  1 
ATOM   1543 C  CG1 . VAL A 1 202 ? 3.75028   11.22308  -34.22876 1.000 28.82404 ? 202 VAL A CG1 1 
ATOM   1544 C  CG2 . VAL A 1 202 ? 5.69864   12.81951  -34.21058 1.000 27.73756 ? 202 VAL A CG2 1 
ATOM   1545 N  N   . ASN A 1 203 ? 5.36834   9.07671   -32.53341 1.000 28.54958 ? 203 ASN A N   1 
ATOM   1546 C  CA  . ASN A 1 203 ? 5.38773   8.71882   -31.11948 1.000 29.39387 ? 203 ASN A CA  1 
ATOM   1547 C  C   . ASN A 1 203 ? 6.60921   7.87402   -30.78006 1.000 29.61934 ? 203 ASN A C   1 
ATOM   1548 O  O   . ASN A 1 203 ? 7.19077   8.02260   -29.69770 1.000 25.80273 ? 203 ASN A O   1 
ATOM   1549 C  CB  . ASN A 1 203 ? 4.09943   7.98420   -30.74522 1.000 30.06586 ? 203 ASN A CB  1 
ATOM   1550 C  CG  . ASN A 1 203 ? 2.90783   8.91750   -30.62389 1.000 30.75236 ? 203 ASN A CG  1 
ATOM   1551 O  OD1 . ASN A 1 203 ? 2.98742   10.09667  -30.97006 1.000 32.05375 ? 203 ASN A OD1 1 
ATOM   1552 N  ND2 . ASN A 1 203 ? 1.79467   8.39108   -30.13225 1.000 27.23685 ? 203 ASN A ND2 1 
ATOM   1553 N  N   . VAL A 1 204 ? 7.00824   6.97718   -31.68620 1.000 27.30999 ? 204 VAL A N   1 
ATOM   1554 C  CA  . VAL A 1 204 ? 8.22180   6.19231   -31.46879 1.000 33.51967 ? 204 VAL A CA  1 
ATOM   1555 C  C   . VAL A 1 204 ? 9.43337   7.11077   -31.37697 1.000 33.44565 ? 204 VAL A C   1 
ATOM   1556 O  O   . VAL A 1 204 ? 10.29106  6.95552   -30.49918 1.000 34.94184 ? 204 VAL A O   1 
ATOM   1557 C  CB  . VAL A 1 204 ? 8.39572   5.14751   -32.58485 1.000 32.77334 ? 204 VAL A CB  1 
ATOM   1558 C  CG1 . VAL A 1 204 ? 9.76530   4.48757   -32.48876 1.000 32.66552 ? 204 VAL A CG1 1 
ATOM   1559 C  CG2 . VAL A 1 204 ? 7.29310   4.10907   -32.51722 1.000 25.53054 ? 204 VAL A CG2 1 
ATOM   1560 N  N   . LEU A 1 205 ? 9.51755   8.08224   -32.28860 1.000 28.30598 ? 205 LEU A N   1 
ATOM   1561 C  CA  . LEU A 1 205 ? 10.63737  9.01737   -32.28127 1.000 30.25985 ? 205 LEU A CA  1 
ATOM   1562 C  C   . LEU A 1 205 ? 10.68946  9.80752   -30.98177 1.000 30.70171 ? 205 LEU A C   1 
ATOM   1563 O  O   . LEU A 1 205 ? 11.76466  9.98186   -30.39547 1.000 31.62144 ? 205 LEU A O   1 
ATOM   1564 C  CB  . LEU A 1 205 ? 10.53710  9.95993   -33.48057 1.000 28.67742 ? 205 LEU A CB  1 
ATOM   1565 C  CG  . LEU A 1 205 ? 10.88907  9.32942   -34.82664 1.000 29.04053 ? 205 LEU A CG  1 
ATOM   1566 C  CD1 . LEU A 1 205 ? 10.62722  10.30340  -35.96999 1.000 28.19727 ? 205 LEU A CD1 1 
ATOM   1567 C  CD2 . LEU A 1 205 ? 12.34144  8.87784   -34.81732 1.000 24.36423 ? 205 LEU A CD2 1 
ATOM   1568 N  N   . ALA A 1 206 ? 9.53615   10.29268  -30.51452 1.000 35.64875 ? 206 ALA A N   1 
ATOM   1569 C  CA  . ALA A 1 206 ? 9.49839   11.00851  -29.24373 1.000 34.58128 ? 206 ALA A CA  1 
ATOM   1570 C  C   . ALA A 1 206 ? 9.94970   10.11220  -28.09827 1.000 34.97088 ? 206 ALA A C   1 
ATOM   1571 O  O   . ALA A 1 206 ? 10.60197  10.57312  -27.15429 1.000 33.12738 ? 206 ALA A O   1 
ATOM   1572 C  CB  . ALA A 1 206 ? 8.09105   11.54451  -28.98536 1.000 29.07656 ? 206 ALA A CB  1 
ATOM   1573 N  N   . TRP A 1 207 ? 9.61704   8.82386   -28.17294 1.000 33.23398 ? 207 TRP A N   1 
ATOM   1574 C  CA  . TRP A 1 207 ? 10.00912  7.88125   -27.13405 1.000 31.96374 ? 207 TRP A CA  1 
ATOM   1575 C  C   . TRP A 1 207 ? 11.50829  7.60552   -27.16579 1.000 37.81332 ? 207 TRP A C   1 
ATOM   1576 O  O   . TRP A 1 207 ? 12.12389  7.41507   -26.11059 1.000 37.57376 ? 207 TRP A O   1 
ATOM   1577 C  CB  . TRP A 1 207 ? 9.19956   6.59618   -27.30300 1.000 29.76196 ? 207 TRP A CB  1 
ATOM   1578 C  CG  . TRP A 1 207 ? 9.49830   5.50283   -26.33226 1.000 37.18024 ? 207 TRP A CG  1 
ATOM   1579 C  CD1 . TRP A 1 207 ? 9.16551   5.46060   -25.00866 1.000 39.91614 ? 207 TRP A CD1 1 
ATOM   1580 C  CD2 . TRP A 1 207 ? 10.15110  4.26361   -26.62219 1.000 38.54296 ? 207 TRP A CD2 1 
ATOM   1581 N  NE1 . TRP A 1 207 ? 9.59007   4.27726   -24.45373 1.000 36.66420 ? 207 TRP A NE1 1 
ATOM   1582 C  CE2 . TRP A 1 207 ? 10.19772  3.52539   -25.42497 1.000 35.77097 ? 207 TRP A CE2 1 
ATOM   1583 C  CE3 . TRP A 1 207 ? 10.70975  3.71070   -27.77799 1.000 44.54931 ? 207 TRP A CE3 1 
ATOM   1584 C  CZ2 . TRP A 1 207 ? 10.77932  2.26506   -25.35106 1.000 42.83846 ? 207 TRP A CZ2 1 
ATOM   1585 C  CZ3 . TRP A 1 207 ? 11.28855  2.45847   -27.70106 1.000 43.26713 ? 207 TRP A CZ3 1 
ATOM   1586 C  CH2 . TRP A 1 207 ? 11.31808  1.74971   -26.49736 1.000 38.81009 ? 207 TRP A CH2 1 
ATOM   1587 N  N   . LEU A 1 208 ? 12.11187  7.58662   -28.35908 1.000 35.83109 ? 208 LEU A N   1 
ATOM   1588 C  CA  . LEU A 1 208 ? 13.56260  7.45537   -28.45353 1.000 35.36644 ? 208 LEU A CA  1 
ATOM   1589 C  C   . LEU A 1 208 ? 14.27037  8.68501   -27.89958 1.000 35.72613 ? 208 LEU A C   1 
ATOM   1590 O  O   . LEU A 1 208 ? 15.35545  8.56502   -27.31923 1.000 36.35804 ? 208 LEU A O   1 
ATOM   1591 C  CB  . LEU A 1 208 ? 13.98128  7.21437   -29.90428 1.000 29.43145 ? 208 LEU A CB  1 
ATOM   1592 C  CG  . LEU A 1 208 ? 13.54829  5.89632   -30.55161 1.000 31.27588 ? 208 LEU A CG  1 
ATOM   1593 C  CD1 . LEU A 1 208 ? 14.02382  5.83414   -31.99560 1.000 23.41199 ? 208 LEU A CD1 1 
ATOM   1594 C  CD2 . LEU A 1 208 ? 14.07084  4.70995   -29.75606 1.000 27.37322 ? 208 LEU A CD2 1 
ATOM   1595 N  N   . TYR A 1 209 ? 13.68041  9.87039   -28.07312 1.000 31.28248 ? 209 TYR A N   1 
ATOM   1596 C  CA  . TYR A 1 209 ? 14.24561  11.07085  -27.46609 1.000 35.04156 ? 209 TYR A CA  1 
ATOM   1597 C  C   . TYR A 1 209 ? 14.20234  10.98839  -25.94600 1.000 42.26927 ? 209 TYR A C   1 
ATOM   1598 O  O   . TYR A 1 209 ? 15.16086  11.37632  -25.26792 1.000 42.16554 ? 209 TYR A O   1 
ATOM   1599 C  CB  . TYR A 1 209 ? 13.50002  12.31309  -27.95251 1.000 30.39136 ? 209 TYR A CB  1 
ATOM   1600 C  CG  . TYR A 1 209 ? 13.99922  12.86138  -29.26595 1.000 38.41137 ? 209 TYR A CG  1 
ATOM   1601 C  CD1 . TYR A 1 209 ? 15.24151  13.47695  -29.35653 1.000 38.92859 ? 209 TYR A CD1 1 
ATOM   1602 C  CD2 . TYR A 1 209 ? 13.22561  12.77614  -30.41457 1.000 42.34954 ? 209 TYR A CD2 1 
ATOM   1603 C  CE1 . TYR A 1 209 ? 15.70309  13.98424  -30.55577 1.000 35.90542 ? 209 TYR A CE1 1 
ATOM   1604 C  CE2 . TYR A 1 209 ? 13.67807  13.28197  -31.62003 1.000 36.10239 ? 209 TYR A CE2 1 
ATOM   1605 C  CZ  . TYR A 1 209 ? 14.91663  13.88586  -31.68406 1.000 40.24302 ? 209 TYR A CZ  1 
ATOM   1606 O  OH  . TYR A 1 209 ? 15.37102  14.39232  -32.87938 1.000 33.27071 ? 209 TYR A OH  1 
ATOM   1607 N  N   . ALA A 1 210 ? 13.09587  10.48432  -25.39185 1.000 37.72734 ? 210 ALA A N   1 
ATOM   1608 C  CA  . ALA A 1 210 ? 13.01533  10.29618  -23.94794 1.000 44.81950 ? 210 ALA A CA  1 
ATOM   1609 C  C   . ALA A 1 210 ? 14.02789  9.26768   -23.46477 1.000 47.38555 ? 210 ALA A C   1 
ATOM   1610 O  O   . ALA A 1 210 ? 14.49434  9.34473   -22.32287 1.000 42.59721 ? 210 ALA A O   1 
ATOM   1611 C  CB  . ALA A 1 210 ? 11.60048  9.87887   -23.54751 1.000 34.92884 ? 210 ALA A CB  1 
ATOM   1612 N  N   . ALA A 1 211 ? 14.37671  8.29950   -24.31482 1.000 41.63649 ? 211 ALA A N   1 
ATOM   1613 C  CA  . ALA A 1 211 ? 15.40287  7.32900   -23.95044 1.000 44.20931 ? 211 ALA A CA  1 
ATOM   1614 C  C   . ALA A 1 211 ? 16.77586  7.98404   -23.86929 1.000 44.90931 ? 211 ALA A C   1 
ATOM   1615 O  O   . ALA A 1 211 ? 17.55872  7.68847   -22.95942 1.000 49.50615 ? 211 ALA A O   1 
ATOM   1616 C  CB  . ALA A 1 211 ? 15.41631  6.17939   -24.95565 1.000 40.68713 ? 211 ALA A CB  1 
ATOM   1617 N  N   . VAL A 1 212 ? 17.08633  8.87262   -24.81547 1.000 42.21283 ? 212 VAL A N   1 
ATOM   1618 C  CA  . VAL A 1 212 ? 18.35076  9.60149   -24.77090 1.000 44.73362 ? 212 VAL A CA  1 
ATOM   1619 C  C   . VAL A 1 212 ? 18.40390  10.49896  -23.54162 1.000 47.34932 ? 212 VAL A C   1 
ATOM   1620 O  O   . VAL A 1 212 ? 19.44436  10.61865  -22.88366 1.000 46.67049 ? 212 VAL A O   1 
ATOM   1621 C  CB  . VAL A 1 212 ? 18.54520  10.40562  -26.07017 1.000 42.24831 ? 212 VAL A CB  1 
ATOM   1622 C  CG1 . VAL A 1 212 ? 19.73230  11.35123  -25.94250 1.000 39.46297 ? 212 VAL A CG1 1 
ATOM   1623 C  CG2 . VAL A 1 212 ? 18.72770  9.46391   -27.25279 1.000 31.83234 ? 212 VAL A CG2 1 
ATOM   1624 N  N   . ILE A 1 213 ? 17.28139  11.13811  -23.20976 1.000 51.36639 ? 213 ILE A N   1 
ATOM   1625 C  CA  . ILE A 1 213 ? 17.23778  12.02931  -22.05380 1.000 52.63438 ? 213 ILE A CA  1 
ATOM   1626 C  C   . ILE A 1 213 ? 17.53325  11.25915  -20.77250 1.000 50.39207 ? 213 ILE A C   1 
ATOM   1627 O  O   . ILE A 1 213 ? 18.23118  11.75450  -19.87862 1.000 50.70096 ? 213 ILE A O   1 
ATOM   1628 C  CB  . ILE A 1 213 ? 15.87516  12.74702  -21.99566 1.000 56.09786 ? 213 ILE A CB  1 
ATOM   1629 C  CG1 . ILE A 1 213 ? 15.80496  13.82954  -23.07620 1.000 55.70167 ? 213 ILE A CG1 1 
ATOM   1630 C  CG2 . ILE A 1 213 ? 15.62244  13.33389  -20.61421 1.000 60.27368 ? 213 ILE A CG2 1 
ATOM   1631 C  CD1 . ILE A 1 213 ? 14.41702  14.39049  -23.29619 1.000 60.45437 ? 213 ILE A CD1 1 
ATOM   1632 N  N   . ASN A 1 214 ? 17.03135  10.03062  -20.67127 1.000 49.33672 ? 214 ASN A N   1 
ATOM   1633 C  CA  . ASN A 1 214 ? 17.24530  9.19925   -19.49583 1.000 52.13676 ? 214 ASN A CA  1 
ATOM   1634 C  C   . ASN A 1 214 ? 18.54821  8.40821   -19.55464 1.000 53.24359 ? 214 ASN A C   1 
ATOM   1635 O  O   . ASN A 1 214 ? 18.77587  7.55263   -18.69360 1.000 50.53815 ? 214 ASN A O   1 
ATOM   1636 C  CB  . ASN A 1 214 ? 16.06358  8.24806   -19.30071 1.000 52.23246 ? 214 ASN A CB  1 
ATOM   1637 C  CG  . ASN A 1 214 ? 14.84483  8.94588   -18.72697 1.000 66.50681 ? 214 ASN A CG  1 
ATOM   1638 O  OD1 . ASN A 1 214 ? 14.67365  9.01909   -17.50962 1.000 73.66638 ? 214 ASN A OD1 1 
ATOM   1639 N  ND2 . ASN A 1 214 ? 13.99052  9.46320   -19.60207 1.000 61.57407 ? 214 ASN A ND2 1 
ATOM   1640 N  N   . GLY A 1 215 ? 19.39801  8.66262   -20.54652 1.000 46.76663 ? 215 GLY A N   1 
ATOM   1641 C  CA  . GLY A 1 215 ? 20.73125  8.09704   -20.57798 1.000 51.55235 ? 215 GLY A CA  1 
ATOM   1642 C  C   . GLY A 1 215 ? 20.94433  6.89943   -21.47745 1.000 53.64820 ? 215 GLY A C   1 
ATOM   1643 O  O   . GLY A 1 215 ? 22.03870  6.32502   -21.45383 1.000 53.65489 ? 215 GLY A O   1 
ATOM   1644 N  N   . ASP A 1 216 ? 19.94697  6.50055   -22.26274 1.000 53.79535 ? 216 ASP A N   1 
ATOM   1645 C  CA  . ASP A 1 216 ? 20.09190  5.38754   -23.19437 1.000 50.48557 ? 216 ASP A CA  1 
ATOM   1646 C  C   . ASP A 1 216 ? 20.50773  5.92643   -24.55887 1.000 48.88565 ? 216 ASP A C   1 
ATOM   1647 O  O   . ASP A 1 216 ? 19.76532  6.69599   -25.17793 1.000 53.44779 ? 216 ASP A O   1 
ATOM   1648 C  CB  . ASP A 1 216 ? 18.78722  4.59888   -23.30233 1.000 49.92635 ? 216 ASP A CB  1 
ATOM   1649 C  CG  . ASP A 1 216 ? 18.86663  3.23794   -22.63576 1.000 53.25003 ? 216 ASP A CG  1 
ATOM   1650 O  OD1 . ASP A 1 216 ? 19.98331  2.69217   -22.52366 1.000 67.38107 ? 216 ASP A OD1 1 
ATOM   1651 O  OD2 . ASP A 1 216 ? 17.80836  2.70956   -22.23287 1.000 58.51084 ? 216 ASP A OD2 1 
ATOM   1652 N  N   . ARG A 1 217 ? 21.69256  5.52337   -25.02669 1.000 41.32239 ? 217 ARG A N   1 
ATOM   1653 C  CA  . ARG A 1 217 ? 22.21396  5.98799   -26.30490 1.000 34.43489 ? 217 ARG A CA  1 
ATOM   1654 C  C   . ARG A 1 217 ? 22.70141  4.87185   -27.21816 1.000 36.88847 ? 217 ARG A C   1 
ATOM   1655 O  O   . ARG A 1 217 ? 23.22163  5.16954   -28.29967 1.000 34.29377 ? 217 ARG A O   1 
ATOM   1656 C  CB  . ARG A 1 217 ? 23.37208  6.97471   -26.08952 1.000 42.23703 ? 217 ARG A CB  1 
ATOM   1657 C  CG  . ARG A 1 217 ? 23.00748  8.24457   -25.34617 1.000 51.36455 ? 217 ARG A CG  1 
ATOM   1658 C  CD  . ARG A 1 217 ? 24.22736  9.13553   -25.20288 1.000 37.92783 ? 217 ARG A CD  1 
ATOM   1659 N  NE  . ARG A 1 217 ? 24.85919  9.38019   -26.49400 1.000 46.42644 ? 217 ARG A NE  1 
ATOM   1660 C  CZ  . ARG A 1 217 ? 24.67535  10.47075  -27.22579 1.000 46.45564 ? 217 ARG A CZ  1 
ATOM   1661 N  NH1 . ARG A 1 217 ? 23.90237  11.46046  -26.80986 1.000 49.10713 ? 217 ARG A NH1 1 
ATOM   1662 N  NH2 . ARG A 1 217 ? 25.28298  10.57120  -28.40464 1.000 45.30793 ? 217 ARG A NH2 1 
ATOM   1663 N  N   . TRP A 1 218 ? 22.54456  3.60419   -26.82903 1.000 32.89488 ? 218 TRP A N   1 
ATOM   1664 C  CA  . TRP A 1 218 ? 23.17843  2.51758   -27.56921 1.000 35.96482 ? 218 TRP A CA  1 
ATOM   1665 C  C   . TRP A 1 218 ? 22.65451  2.38136   -28.99410 1.000 33.83924 ? 218 TRP A C   1 
ATOM   1666 O  O   . TRP A 1 218 ? 23.31898  1.75369   -29.82585 1.000 34.36441 ? 218 TRP A O   1 
ATOM   1667 C  CB  . TRP A 1 218 ? 22.99911  1.19119   -26.82203 1.000 34.33970 ? 218 TRP A CB  1 
ATOM   1668 C  CG  . TRP A 1 218 ? 21.58001  0.69709   -26.73411 1.000 35.03817 ? 218 TRP A CG  1 
ATOM   1669 C  CD1 . TRP A 1 218 ? 20.72781  0.84016   -25.67625 1.000 35.10512 ? 218 TRP A CD1 1 
ATOM   1670 C  CD2 . TRP A 1 218 ? 20.85553  -0.03632  -27.73524 1.000 36.57356 ? 218 TRP A CD2 1 
ATOM   1671 N  NE1 . TRP A 1 218 ? 19.51899  0.24872   -25.95823 1.000 39.92372 ? 218 TRP A NE1 1 
ATOM   1672 C  CE2 . TRP A 1 218 ? 19.57069  -0.29410  -27.21549 1.000 41.56072 ? 218 TRP A CE2 1 
ATOM   1673 C  CE3 . TRP A 1 218 ? 21.16636  -0.49345  -29.02068 1.000 35.37921 ? 218 TRP A CE3 1 
ATOM   1674 C  CZ2 . TRP A 1 218 ? 18.59949  -0.99036  -27.93467 1.000 38.43980 ? 218 TRP A CZ2 1 
ATOM   1675 C  CZ3 . TRP A 1 218 ? 20.19998  -1.18333  -29.73389 1.000 38.52501 ? 218 TRP A CZ3 1 
ATOM   1676 C  CH2 . TRP A 1 218 ? 18.93263  -1.42528  -29.18866 1.000 38.94281 ? 218 TRP A CH2 1 
ATOM   1677 N  N   . PHE A 1 219 ? 21.48750  2.94724   -29.29608 1.000 32.09494 ? 219 PHE A N   1 
ATOM   1678 C  CA  . PHE A 1 219 ? 20.85747  2.77142   -30.59783 1.000 28.13715 ? 219 PHE A CA  1 
ATOM   1679 C  C   . PHE A 1 219 ? 21.20011  3.87474   -31.58955 1.000 32.16146 ? 219 PHE A C   1 
ATOM   1680 O  O   . PHE A 1 219 ? 20.92611  3.71836   -32.78557 1.000 33.27642 ? 219 PHE A O   1 
ATOM   1681 C  CB  . PHE A 1 219 ? 19.33499  2.68713   -30.43537 1.000 28.74246 ? 219 PHE A CB  1 
ATOM   1682 C  CG  . PHE A 1 219 ? 18.75853  3.76977   -29.56670 1.000 32.84509 ? 219 PHE A CG  1 
ATOM   1683 C  CD1 . PHE A 1 219 ? 18.38606  4.98866   -30.10930 1.000 31.00294 ? 219 PHE A CD1 1 
ATOM   1684 C  CD2 . PHE A 1 219 ? 18.59702  3.57106   -28.20367 1.000 33.66306 ? 219 PHE A CD2 1 
ATOM   1685 C  CE1 . PHE A 1 219 ? 17.86009  5.98965   -29.30885 1.000 30.67813 ? 219 PHE A CE1 1 
ATOM   1686 C  CE2 . PHE A 1 219 ? 18.07284  4.56819   -27.39891 1.000 33.55497 ? 219 PHE A CE2 1 
ATOM   1687 C  CZ  . PHE A 1 219 ? 17.70386  5.77832   -27.95286 1.000 32.52858 ? 219 PHE A CZ  1 
ATOM   1688 N  N   . LEU A 1 220 ? 21.77800  4.98025   -31.13127 1.000 34.04141 ? 220 LEU A N   1 
ATOM   1689 C  CA  . LEU A 1 220 ? 22.15428  6.04614   -32.04662 1.000 35.33661 ? 220 LEU A CA  1 
ATOM   1690 C  C   . LEU A 1 220 ? 23.24061  5.56522   -33.00075 1.000 37.63797 ? 220 LEU A C   1 
ATOM   1691 O  O   . LEU A 1 220 ? 23.98927  4.63317   -32.70156 1.000 32.71020 ? 220 LEU A O   1 
ATOM   1692 C  CB  . LEU A 1 220 ? 22.64489  7.26263   -31.26596 1.000 33.94475 ? 220 LEU A CB  1 
ATOM   1693 C  CG  . LEU A 1 220 ? 21.70895  7.81682   -30.18936 1.000 32.56575 ? 220 LEU A CG  1 
ATOM   1694 C  CD1 . LEU A 1 220 ? 22.36045  8.98246   -29.46092 1.000 39.81800 ? 220 LEU A CD1 1 
ATOM   1695 C  CD2 . LEU A 1 220 ? 20.36694  8.23927   -30.77902 1.000 37.27423 ? 220 LEU A CD2 1 
ATOM   1696 N  N   . ASN A 1 221 ? 23.32424  6.20978   -34.16296 1.000 33.73429 ? 221 ASN A N   1 
ATOM   1697 C  CA  . ASN A 1 221 ? 24.37337  5.90584   -35.13184 1.000 31.54221 ? 221 ASN A CA  1 
ATOM   1698 C  C   . ASN A 1 221 ? 24.91911  7.21624   -35.69297 1.000 32.62495 ? 221 ASN A C   1 
ATOM   1699 O  O   . ASN A 1 221 ? 24.53866  8.30851   -35.26421 1.000 31.23546 ? 221 ASN A O   1 
ATOM   1700 C  CB  . ASN A 1 221 ? 23.86675  4.95160   -36.22626 1.000 30.06674 ? 221 ASN A CB  1 
ATOM   1701 C  CG  . ASN A 1 221 ? 22.79643  5.56450   -37.12304 1.000 34.01854 ? 221 ASN A CG  1 
ATOM   1702 O  OD1 . ASN A 1 221 ? 22.63191  6.78332   -37.20332 1.000 37.39528 ? 221 ASN A OD1 1 
ATOM   1703 N  ND2 . ASN A 1 221 ? 22.07466  4.70540   -37.82257 1.000 36.95865 ? 221 ASN A ND2 1 
ATOM   1704 N  N   . ARG A 1 222 ? 25.82562  7.10524   -36.65969 1.000 32.61049 ? 222 ARG A N   1 
ATOM   1705 C  CA  . ARG A 1 222 ? 26.44978  8.26499   -37.28027 1.000 31.01399 ? 222 ARG A CA  1 
ATOM   1706 C  C   . ARG A 1 222 ? 25.75071  8.69780   -38.56264 1.000 35.21473 ? 222 ARG A C   1 
ATOM   1707 O  O   . ARG A 1 222 ? 26.26860  9.56507   -39.27243 1.000 33.27969 ? 222 ARG A O   1 
ATOM   1708 C  CB  . ARG A 1 222 ? 27.92316  7.97525   -37.56898 1.000 37.45040 ? 222 ARG A CB  1 
ATOM   1709 N  N   . PHE A 1 223 ? 24.58271  8.13820   -38.85899 1.000 31.22003 ? 223 PHE A N   1 
ATOM   1710 C  CA  . PHE A 1 223 ? 23.88998  8.36999   -40.11589 1.000 31.88246 ? 223 PHE A CA  1 
ATOM   1711 C  C   . PHE A 1 223 ? 22.84659  9.47322   -39.98606 1.000 36.28967 ? 223 PHE A C   1 
ATOM   1712 O  O   . PHE A 1 223 ? 22.35996  9.78915   -38.89753 1.000 33.05127 ? 223 PHE A O   1 
ATOM   1713 C  CB  . PHE A 1 223 ? 23.21324  7.08567   -40.60311 1.000 32.94062 ? 223 PHE A CB  1 
ATOM   1714 C  CG  . PHE A 1 223 ? 24.11823  6.18065   -41.38165 1.000 37.11335 ? 223 PHE A CG  1 
ATOM   1715 C  CD1 . PHE A 1 223 ? 25.09994  5.44336   -40.74501 1.000 37.15445 ? 223 PHE A CD1 1 
ATOM   1716 C  CD2 . PHE A 1 223 ? 23.98011  6.06061   -42.75426 1.000 48.10089 ? 223 PHE A CD2 1 
ATOM   1717 C  CE1 . PHE A 1 223 ? 25.93577  4.60663   -41.46355 1.000 45.66168 ? 223 PHE A CE1 1 
ATOM   1718 C  CE2 . PHE A 1 223 ? 24.81000  5.22379   -43.47939 1.000 45.54893 ? 223 PHE A CE2 1 
ATOM   1719 C  CZ  . PHE A 1 223 ? 25.79002  4.49536   -42.83109 1.000 41.65229 ? 223 PHE A CZ  1 
ATOM   1720 N  N   . THR A 1 224 ? 22.51389  10.06129  -41.12975 1.000 35.31979 ? 224 THR A N   1 
ATOM   1721 C  CA  . THR A 1 224 ? 21.34806  10.91271  -41.28561 1.000 35.90291 ? 224 THR A CA  1 
ATOM   1722 C  C   . THR A 1 224 ? 20.52761  10.36985  -42.44603 1.000 34.47767 ? 224 THR A C   1 
ATOM   1723 O  O   . THR A 1 224 ? 20.93440  9.42850   -43.13399 1.000 36.21201 ? 224 THR A O   1 
ATOM   1724 C  CB  . THR A 1 224 ? 21.73970  12.37612  -41.52585 1.000 42.44149 ? 224 THR A CB  1 
ATOM   1725 O  OG1 . THR A 1 224 ? 20.59413  13.21199  -41.32049 1.000 42.45587 ? 224 THR A OG1 1 
ATOM   1726 C  CG2 . THR A 1 224 ? 22.25111  12.56906  -42.95158 1.000 28.10824 ? 224 THR A CG2 1 
ATOM   1727 N  N   . THR A 1 225 ? 19.36216  10.96874  -42.66703 1.000 31.98623 ? 225 THR A N   1 
ATOM   1728 C  CA  . THR A 1 225 ? 18.51232  10.56279  -43.77318 1.000 32.44795 ? 225 THR A CA  1 
ATOM   1729 C  C   . THR A 1 225 ? 17.68374  11.75263  -44.22521 1.000 31.05176 ? 225 THR A C   1 
ATOM   1730 O  O   . THR A 1 225 ? 17.46322  12.70401  -43.47219 1.000 34.62745 ? 225 THR A O   1 
ATOM   1731 C  CB  . THR A 1 225 ? 17.59222  9.39869   -43.38656 1.000 37.75031 ? 225 THR A CB  1 
ATOM   1732 O  OG1 . THR A 1 225 ? 16.76814  9.04211   -44.50638 1.000 34.91190 ? 225 THR A OG1 1 
ATOM   1733 C  CG2 . THR A 1 225 ? 16.70378  9.79192   -42.20864 1.000 31.77360 ? 225 THR A CG2 1 
ATOM   1734 N  N   . THR A 1 226 ? 17.23719  11.69347  -45.47429 1.000 30.61283 ? 226 THR A N   1 
ATOM   1735 C  CA  . THR A 1 226 ? 16.21988  12.62432  -45.92524 1.000 35.66267 ? 226 THR A CA  1 
ATOM   1736 C  C   . THR A 1 226 ? 14.85521  12.16728  -45.41998 1.000 39.89180 ? 226 THR A C   1 
ATOM   1737 O  O   . THR A 1 226 ? 14.67293  11.02137  -44.99802 1.000 38.18360 ? 226 THR A O   1 
ATOM   1738 C  CB  . THR A 1 226 ? 16.20727  12.72789  -47.44969 1.000 39.23650 ? 226 THR A CB  1 
ATOM   1739 O  OG1 . THR A 1 226 ? 15.65666  11.52765  -48.00394 1.000 34.67260 ? 226 THR A OG1 1 
ATOM   1740 C  CG2 . THR A 1 226 ? 17.62099  12.92128  -47.97997 1.000 34.21826 ? 226 THR A CG2 1 
ATOM   1741 N  N   . LEU A 1 227 ? 13.88728  13.08391  -45.45971 1.000 39.88947 ? 227 LEU A N   1 
ATOM   1742 C  CA  . LEU A 1 227 ? 12.54600  12.73904  -45.00177 1.000 36.55624 ? 227 LEU A CA  1 
ATOM   1743 C  C   . LEU A 1 227 ? 11.91917  11.67953  -45.89652 1.000 35.95220 ? 227 LEU A C   1 
ATOM   1744 O  O   . LEU A 1 227 ? 11.28337  10.73826  -45.40700 1.000 34.86900 ? 227 LEU A O   1 
ATOM   1745 C  CB  . LEU A 1 227 ? 11.66546  13.98767  -44.94859 1.000 41.33721 ? 227 LEU A CB  1 
ATOM   1746 C  CG  . LEU A 1 227 ? 10.28087  13.77038  -44.33468 1.000 43.42984 ? 227 LEU A CG  1 
ATOM   1747 C  CD1 . LEU A 1 227 ? 10.40537  13.16677  -42.94196 1.000 38.83878 ? 227 LEU A CD1 1 
ATOM   1748 C  CD2 . LEU A 1 227 ? 9.50019   15.07394  -44.28816 1.000 37.68838 ? 227 LEU A CD2 1 
ATOM   1749 N  N   . ASN A 1 228 ? 12.10375  11.80653  -47.21259 1.000 37.58997 ? 228 ASN A N   1 
ATOM   1750 C  CA  . ASN A 1 228 ? 11.49051  10.86190  -48.13955 1.000 30.79121 ? 228 ASN A CA  1 
ATOM   1751 C  C   . ASN A 1 228 ? 12.13680  9.48427   -48.04410 1.000 31.73078 ? 228 ASN A C   1 
ATOM   1752 O  O   . ASN A 1 228 ? 11.44038  8.46453   -48.09803 1.000 36.55138 ? 228 ASN A O   1 
ATOM   1753 C  CB  . ASN A 1 228 ? 11.57284  11.39955  -49.56792 1.000 44.13854 ? 228 ASN A CB  1 
ATOM   1754 C  CG  . ASN A 1 228 ? 10.76691  10.56858  -50.54660 1.000 46.02940 ? 228 ASN A CG  1 
ATOM   1755 O  OD1 . ASN A 1 228 ? 9.53973   10.50076  -50.45287 1.000 53.53480 ? 228 ASN A OD1 1 
ATOM   1756 N  ND2 . ASN A 1 228 ? 11.45008  9.93338   -51.49201 1.000 44.65415 ? 228 ASN A ND2 1 
ATOM   1757 N  N   . ASP A 1 229 ? 13.46396  9.42993   -47.89879 1.000 33.50120 ? 229 ASP A N   1 
ATOM   1758 C  CA  . ASP A 1 229 ? 14.13729  8.14069   -47.75828 1.000 34.66783 ? 229 ASP A CA  1 
ATOM   1759 C  C   . ASP A 1 229 ? 13.70614  7.42297   -46.48390 1.000 34.40527 ? 229 ASP A C   1 
ATOM   1760 O  O   . ASP A 1 229 ? 13.58015  6.19291   -46.46738 1.000 34.68615 ? 229 ASP A O   1 
ATOM   1761 C  CB  . ASP A 1 229 ? 15.65361  8.33141   -47.77876 1.000 39.61719 ? 229 ASP A CB  1 
ATOM   1762 C  CG  . ASP A 1 229 ? 16.19812  8.52013   -49.18160 1.000 40.00254 ? 229 ASP A CG  1 
ATOM   1763 O  OD1 . ASP A 1 229 ? 15.41651  8.38100   -50.14580 1.000 41.83315 ? 229 ASP A OD1 1 
ATOM   1764 O  OD2 . ASP A 1 229 ? 17.40909  8.80061   -49.32175 1.000 42.58534 ? 229 ASP A OD2 1 
ATOM   1765 N  N   . PHE A 1 230 ? 13.47116  8.17314   -45.40582 1.000 29.77682 ? 230 PHE A N   1 
ATOM   1766 C  CA  . PHE A 1 230 ? 12.98568  7.55463   -44.17659 1.000 35.09726 ? 230 PHE A CA  1 
ATOM   1767 C  C   . PHE A 1 230 ? 11.60070  6.94779   -44.36792 1.000 35.35017 ? 230 PHE A C   1 
ATOM   1768 O  O   . PHE A 1 230 ? 11.34148  5.82490   -43.91867 1.000 37.36172 ? 230 PHE A O   1 
ATOM   1769 C  CB  . PHE A 1 230 ? 12.96015  8.57328   -43.03728 1.000 32.93911 ? 230 PHE A CB  1 
ATOM   1770 C  CG  . PHE A 1 230 ? 12.26779  8.06964   -41.80261 1.000 38.41201 ? 230 PHE A CG  1 
ATOM   1771 C  CD1 . PHE A 1 230 ? 12.91963  7.21344   -40.93103 1.000 30.31960 ? 230 PHE A CD1 1 
ATOM   1772 C  CD2 . PHE A 1 230 ? 10.96241  8.44064   -41.52020 1.000 34.20392 ? 230 PHE A CD2 1 
ATOM   1773 C  CE1 . PHE A 1 230 ? 12.28879  6.74105   -39.79719 1.000 40.38475 ? 230 PHE A CE1 1 
ATOM   1774 C  CE2 . PHE A 1 230 ? 10.32369  7.96897   -40.38657 1.000 31.41528 ? 230 PHE A CE2 1 
ATOM   1775 C  CZ  . PHE A 1 230 ? 10.98821  7.11934   -39.52507 1.000 38.22421 ? 230 PHE A CZ  1 
ATOM   1776 N  N   . ASN A 1 231 ? 10.69398  7.67861   -45.02474 1.000 32.64039 ? 231 ASN A N   1 
ATOM   1777 C  CA  . ASN A 1 231 ? 9.32640   7.19043   -45.18595 1.000 35.04038 ? 231 ASN A CA  1 
ATOM   1778 C  C   . ASN A 1 231 ? 9.27267   5.96135   -46.08409 1.000 36.46787 ? 231 ASN A C   1 
ATOM   1779 O  O   . ASN A 1 231 ? 8.50882   5.02622   -45.81648 1.000 35.09575 ? 231 ASN A O   1 
ATOM   1780 C  CB  . ASN A 1 231 ? 8.43093   8.30094   -45.73538 1.000 30.37594 ? 231 ASN A CB  1 
ATOM   1781 C  CG  . ASN A 1 231 ? 8.09141   9.34033   -44.68883 1.000 31.97870 ? 231 ASN A CG  1 
ATOM   1782 O  OD1 . ASN A 1 231 ? 8.01060   9.03220   -43.50247 1.000 34.27314 ? 231 ASN A OD1 1 
ATOM   1783 N  ND2 . ASN A 1 231 ? 7.89081   10.57869  -45.12211 1.000 37.85949 ? 231 ASN A ND2 1 
ATOM   1784 N  N   . LEU A 1 232 ? 10.07455  5.94245   -47.15258 1.000 34.73244 ? 232 LEU A N   1 
ATOM   1785 C  CA  . LEU A 1 232 ? 10.11068  4.77370   -48.02599 1.000 35.14589 ? 232 LEU A CA  1 
ATOM   1786 C  C   . LEU A 1 232 ? 10.56708  3.52940   -47.27574 1.000 35.42736 ? 232 LEU A C   1 
ATOM   1787 O  O   . LEU A 1 232 ? 10.12273  2.41867   -47.58694 1.000 39.46072 ? 232 LEU A O   1 
ATOM   1788 C  CB  . LEU A 1 232 ? 11.02605  5.04077   -49.22277 1.000 34.47183 ? 232 LEU A CB  1 
ATOM   1789 C  CG  . LEU A 1 232 ? 10.59065  6.13552   -50.20045 1.000 40.76494 ? 232 LEU A CG  1 
ATOM   1790 C  CD1 . LEU A 1 232 ? 11.73367  6.50394   -51.13779 1.000 38.93768 ? 232 LEU A CD1 1 
ATOM   1791 C  CD2 . LEU A 1 232 ? 9.36312   5.69907   -50.98965 1.000 30.53707 ? 232 LEU A CD2 1 
ATOM   1792 N  N   . VAL A 1 233 ? 11.44725  3.69268   -46.28843 1.000 34.12845 ? 233 VAL A N   1 
ATOM   1793 C  CA  . VAL A 1 233 ? 11.90233  2.55596   -45.49413 1.000 39.33180 ? 233 VAL A CA  1 
ATOM   1794 C  C   . VAL A 1 233 ? 10.88828  2.21120   -44.41277 1.000 35.32504 ? 233 VAL A C   1 
ATOM   1795 O  O   . VAL A 1 233 ? 10.50268  1.04803   -44.25051 1.000 34.62192 ? 233 VAL A O   1 
ATOM   1796 C  CB  . VAL A 1 233 ? 13.28334  2.84919   -44.88190 1.000 38.04410 ? 233 VAL A CB  1 
ATOM   1797 C  CG1 . VAL A 1 233 ? 13.64783  1.77650   -43.86534 1.000 29.52044 ? 233 VAL A CG1 1 
ATOM   1798 C  CG2 . VAL A 1 233 ? 14.33001  2.94190   -45.96641 1.000 36.13104 ? 233 VAL A CG2 1 
ATOM   1799 N  N   . ALA A 1 234 ? 10.44960  3.21767   -43.65306 1.000 34.49032 ? 234 ALA A N   1 
ATOM   1800 C  CA  . ALA A 1 234 ? 9.59096   2.96456   -42.50005 1.000 37.56495 ? 234 ALA A CA  1 
ATOM   1801 C  C   . ALA A 1 234 ? 8.25544   2.35825   -42.91207 1.000 38.45283 ? 234 ALA A C   1 
ATOM   1802 O  O   . ALA A 1 234 ? 7.71099   1.50463   -42.20170 1.000 40.07900 ? 234 ALA A O   1 
ATOM   1803 C  CB  . ALA A 1 234 ? 9.37505   4.25769   -41.71668 1.000 33.26774 ? 234 ALA A CB  1 
ATOM   1804 N  N   . MET A 1 235 ? 7.71407   2.77879   -44.05831 1.000 36.37050 ? 235 MET A N   1 
ATOM   1805 C  CA  . MET A 1 235 ? 6.43775   2.24041   -44.51430 1.000 38.23177 ? 235 MET A CA  1 
ATOM   1806 C  C   . MET A 1 235 ? 6.53927   0.77889   -44.92807 1.000 38.09982 ? 235 MET A C   1 
ATOM   1807 O  O   . MET A 1 235 ? 5.51039   0.09934   -45.00891 1.000 39.93451 ? 235 MET A O   1 
ATOM   1808 C  CB  . MET A 1 235 ? 5.89140   3.08300   -45.66758 1.000 37.43748 ? 235 MET A CB  1 
ATOM   1809 C  CG  . MET A 1 235 ? 5.38523   4.44977   -45.22867 1.000 43.91928 ? 235 MET A CG  1 
ATOM   1810 S  SD  . MET A 1 235 ? 4.91290   5.51182   -46.60298 1.000 65.12140 ? 235 MET A SD  1 
ATOM   1811 C  CE  . MET A 1 235 ? 3.66354   4.50242   -47.39891 1.000 63.02665 ? 235 MET A CE  1 
ATOM   1812 N  N   . LYS A 1 236 ? 7.74928   0.28071   -45.18800 1.000 29.77148 ? 236 LYS A N   1 
ATOM   1813 C  CA  . LYS A 1 236 ? 7.94208   -1.14666  -45.40785 1.000 34.99644 ? 236 LYS A CA  1 
ATOM   1814 C  C   . LYS A 1 236 ? 7.78197   -1.96083  -44.13073 1.000 31.25088 ? 236 LYS A C   1 
ATOM   1815 O  O   . LYS A 1 236 ? 7.66208   -3.18791  -44.20973 1.000 39.17668 ? 236 LYS A O   1 
ATOM   1816 C  CB  . LYS A 1 236 ? 9.32438   -1.40488  -46.01073 1.000 41.08439 ? 236 LYS A CB  1 
ATOM   1817 C  CG  . LYS A 1 236 ? 9.53747   -0.81126  -47.39611 1.000 40.73038 ? 236 LYS A CG  1 
ATOM   1818 C  CD  . LYS A 1 236 ? 11.00708  -0.90315  -47.79490 1.000 45.49097 ? 236 LYS A CD  1 
ATOM   1819 C  CE  . LYS A 1 236 ? 11.20497  -0.77577  -49.29827 1.000 47.93053 ? 236 LYS A CE  1 
ATOM   1820 N  NZ  . LYS A 1 236 ? 11.10458  0.62314   -49.79690 1.000 52.85140 ? 236 LYS A NZ  1 
ATOM   1821 N  N   . TYR A 1 237 ? 7.79275   -1.31314  -42.96492 1.000 31.76797 ? 237 TYR A N   1 
ATOM   1822 C  CA  . TYR A 1 237 ? 7.56291   -1.96709  -41.68266 1.000 30.35625 ? 237 TYR A CA  1 
ATOM   1823 C  C   . TYR A 1 237 ? 6.19112   -1.62883  -41.10680 1.000 36.92218 ? 237 TYR A C   1 
ATOM   1824 O  O   . TYR A 1 237 ? 5.96887   -1.80154  -39.90383 1.000 37.28659 ? 237 TYR A O   1 
ATOM   1825 C  CB  . TYR A 1 237 ? 8.65466   -1.58274  -40.68368 1.000 29.49750 ? 237 TYR A CB  1 
ATOM   1826 C  CG  . TYR A 1 237 ? 10.05954  -1.94625  -41.10894 1.000 36.32499 ? 237 TYR A CG  1 
ATOM   1827 C  CD1 . TYR A 1 237 ? 10.82852  -1.06881  -41.86314 1.000 32.13626 ? 237 TYR A CD1 1 
ATOM   1828 C  CD2 . TYR A 1 237 ? 10.62221  -3.16261  -40.74473 1.000 35.83260 ? 237 TYR A CD2 1 
ATOM   1829 C  CE1 . TYR A 1 237 ? 12.11981  -1.39673  -42.24884 1.000 33.76228 ? 237 TYR A CE1 1 
ATOM   1830 C  CE2 . TYR A 1 237 ? 11.90873  -3.49954  -41.12463 1.000 36.35122 ? 237 TYR A CE2 1 
ATOM   1831 C  CZ  . TYR A 1 237 ? 12.65379  -2.61339  -41.87654 1.000 39.75588 ? 237 TYR A CZ  1 
ATOM   1832 O  OH  . TYR A 1 237 ? 13.93396  -2.94708  -42.25651 1.000 40.54320 ? 237 TYR A OH  1 
ATOM   1833 N  N   . ASN A 1 238 ? 5.27406   -1.14000  -41.94568 1.000 33.02503 ? 238 ASN A N   1 
ATOM   1834 C  CA  . ASN A 1 238 ? 3.94226   -0.70061  -41.51817 1.000 42.70398 ? 238 ASN A CA  1 
ATOM   1835 C  C   . ASN A 1 238 ? 4.02165   0.41165   -40.47476 1.000 37.26103 ? 238 ASN A C   1 
ATOM   1836 O  O   . ASN A 1 238 ? 3.26677   0.42896   -39.50074 1.000 32.04923 ? 238 ASN A O   1 
ATOM   1837 C  CB  . ASN A 1 238 ? 3.09984   -1.87065  -41.00342 1.000 37.93085 ? 238 ASN A CB  1 
ATOM   1838 C  CG  . ASN A 1 238 ? 2.37588   -2.59663  -42.11853 1.000 41.56963 ? 238 ASN A CG  1 
ATOM   1839 O  OD1 . ASN A 1 238 ? 2.24215   -2.07666  -43.22618 1.000 46.24624 ? 238 ASN A OD1 1 
ATOM   1840 N  ND2 . ASN A 1 238 ? 1.89386   -3.79855  -41.82890 1.000 53.71227 ? 238 ASN A ND2 1 
ATOM   1841 N  N   . TYR A 1 239 ? 4.94242   1.34754   -40.68187 1.000 33.54191 ? 239 TYR A N   1 
ATOM   1842 C  CA  . TYR A 1 239 ? 4.99734   2.56667   -39.89194 1.000 29.14255 ? 239 TYR A CA  1 
ATOM   1843 C  C   . TYR A 1 239 ? 4.25823   3.68405   -40.61546 1.000 31.96767 ? 239 TYR A C   1 
ATOM   1844 O  O   . TYR A 1 239 ? 4.23139   3.74055   -41.84770 1.000 35.26099 ? 239 TYR A O   1 
ATOM   1845 C  CB  . TYR A 1 239 ? 6.44560   2.98614   -39.62908 1.000 32.80732 ? 239 TYR A CB  1 
ATOM   1846 C  CG  . TYR A 1 239 ? 7.03704   2.41877   -38.35782 1.000 30.89000 ? 239 TYR A CG  1 
ATOM   1847 C  CD1 . TYR A 1 239 ? 7.10149   1.04855   -38.15028 1.000 25.87859 ? 239 TYR A CD1 1 
ATOM   1848 C  CD2 . TYR A 1 239 ? 7.54422   3.25625   -37.37257 1.000 28.67547 ? 239 TYR A CD2 1 
ATOM   1849 C  CE1 . TYR A 1 239 ? 7.63970   0.52789   -36.99480 1.000 30.07394 ? 239 TYR A CE1 1 
ATOM   1850 C  CE2 . TYR A 1 239 ? 8.09093   2.74377   -36.21334 1.000 30.45238 ? 239 TYR A CE2 1 
ATOM   1851 C  CZ  . TYR A 1 239 ? 8.13596   1.37851   -36.02971 1.000 33.03977 ? 239 TYR A CZ  1 
ATOM   1852 O  OH  . TYR A 1 239 ? 8.67630   0.86254   -34.87355 1.000 35.10619 ? 239 TYR A OH  1 
ATOM   1853 N  N   . GLU A 1 240 ? 3.65057   4.57071   -39.83714 1.000 31.86787 ? 240 GLU A N   1 
ATOM   1854 C  CA  . GLU A 1 240 ? 2.98043   5.71919   -40.42392 1.000 32.51935 ? 240 GLU A CA  1 
ATOM   1855 C  C   . GLU A 1 240 ? 4.01043   6.66173   -41.04215 1.000 33.80496 ? 240 GLU A C   1 
ATOM   1856 O  O   . GLU A 1 240 ? 5.11507   6.80711   -40.51238 1.000 34.47148 ? 240 GLU A O   1 
ATOM   1857 C  CB  . GLU A 1 240 ? 2.15625   6.45985   -39.36986 1.000 28.71661 ? 240 GLU A CB  1 
ATOM   1858 C  CG  . GLU A 1 240 ? 0.83381   5.78838   -39.03255 1.000 30.84572 ? 240 GLU A CG  1 
ATOM   1859 C  CD  . GLU A 1 240 ? -0.19112  5.93810   -40.14109 1.000 36.63509 ? 240 GLU A CD  1 
ATOM   1860 O  OE1 . GLU A 1 240 ? -0.57683  7.08763   -40.44265 1.000 41.36324 ? 240 GLU A OE1 1 
ATOM   1861 O  OE2 . GLU A 1 240 ? -0.60324  4.90946   -40.71887 1.000 31.83601 ? 240 GLU A OE2 1 
ATOM   1862 N  N   . PRO A 1 241 ? 3.68969   7.29536   -42.16824 1.000 36.69583 ? 241 PRO A N   1 
ATOM   1863 C  CA  . PRO A 1 241 ? 4.60246   8.29635   -42.73060 1.000 38.18234 ? 241 PRO A CA  1 
ATOM   1864 C  C   . PRO A 1 241 ? 4.79719   9.46773   -41.77951 1.000 38.98323 ? 241 PRO A C   1 
ATOM   1865 O  O   . PRO A 1 241 ? 3.86877   9.90196   -41.09521 1.000 40.37964 ? 241 PRO A O   1 
ATOM   1866 C  CB  . PRO A 1 241 ? 3.90343   8.72926   -44.02584 1.000 36.45286 ? 241 PRO A CB  1 
ATOM   1867 C  CG  . PRO A 1 241 ? 2.48306   8.27983   -43.87803 1.000 35.55100 ? 241 PRO A CG  1 
ATOM   1868 C  CD  . PRO A 1 241 ? 2.53808   7.04082   -43.04784 1.000 32.15711 ? 241 PRO A CD  1 
ATOM   1869 N  N   . LEU A 1 242 ? 6.02807   9.96691   -41.73246 1.000 30.78186 ? 242 LEU A N   1 
ATOM   1870 C  CA  . LEU A 1 242 ? 6.36262   11.13979  -40.93870 1.000 33.80495 ? 242 LEU A CA  1 
ATOM   1871 C  C   . LEU A 1 242 ? 6.22428   12.37949  -41.81260 1.000 35.01030 ? 242 LEU A C   1 
ATOM   1872 O  O   . LEU A 1 242 ? 6.72416   12.40746  -42.94155 1.000 41.39206 ? 242 LEU A O   1 
ATOM   1873 C  CB  . LEU A 1 242 ? 7.78397   11.02489  -40.38481 1.000 33.05574 ? 242 LEU A CB  1 
ATOM   1874 C  CG  . LEU A 1 242 ? 8.18242   11.90500  -39.19973 1.000 40.42843 ? 242 LEU A CG  1 
ATOM   1875 C  CD1 . LEU A 1 242 ? 7.57343   11.37360  -37.90878 1.000 30.60511 ? 242 LEU A CD1 1 
ATOM   1876 C  CD2 . LEU A 1 242 ? 9.70014   11.99804  -39.09088 1.000 33.85181 ? 242 LEU A CD2 1 
ATOM   1877 N  N   . THR A 1 243 ? 5.53562   13.39181  -41.29878 1.000 32.63667 ? 243 THR A N   1 
ATOM   1878 C  CA  . THR A 1 243 ? 5.27635   14.61541  -42.04157 1.000 36.02053 ? 243 THR A CA  1 
ATOM   1879 C  C   . THR A 1 243 ? 6.12507   15.75447  -41.49394 1.000 38.19664 ? 243 THR A C   1 
ATOM   1880 O  O   . THR A 1 243 ? 6.74333   15.64978  -40.43120 1.000 34.54589 ? 243 THR A O   1 
ATOM   1881 C  CB  . THR A 1 243 ? 3.79028   14.98981  -41.98296 1.000 40.00961 ? 243 THR A CB  1 
ATOM   1882 O  OG1 . THR A 1 243 ? 3.44307   15.37506  -40.64588 1.000 39.94496 ? 243 THR A OG1 1 
ATOM   1883 C  CG2 . THR A 1 243 ? 2.92803   13.81064  -42.41213 1.000 34.19647 ? 243 THR A CG2 1 
ATOM   1884 N  N   . GLN A 1 244 ? 6.14962   16.85838  -42.24697 1.000 43.09568 ? 244 GLN A N   1 
ATOM   1885 C  CA  . GLN A 1 244 ? 6.87800   18.03767  -41.79301 1.000 42.08907 ? 244 GLN A CA  1 
ATOM   1886 C  C   . GLN A 1 244 ? 6.29240   18.58266  -40.49957 1.000 40.10435 ? 244 GLN A C   1 
ATOM   1887 O  O   . GLN A 1 244 ? 7.02991   19.11204  -39.65977 1.000 39.69680 ? 244 GLN A O   1 
ATOM   1888 C  CB  . GLN A 1 244 ? 6.87310   19.11449  -42.87799 1.000 46.50833 ? 244 GLN A CB  1 
ATOM   1889 C  CG  . GLN A 1 244 ? 7.77245   20.30070  -42.57039 1.000 38.30585 ? 244 GLN A CG  1 
ATOM   1890 C  CD  . GLN A 1 244 ? 9.21618   19.89026  -42.36097 1.000 45.66320 ? 244 GLN A CD  1 
ATOM   1891 O  OE1 . GLN A 1 244 ? 9.77925   19.13377  -43.15242 1.000 45.85319 ? 244 GLN A OE1 1 
ATOM   1892 N  NE2 . GLN A 1 244 ? 9.82111   20.37991  -41.28316 1.000 43.99059 ? 244 GLN A NE2 1 
ATOM   1893 N  N   . ASP A 1 245 ? 4.97365   18.46257  -40.32166 1.000 36.74205 ? 245 ASP A N   1 
ATOM   1894 C  CA  . ASP A 1 245 ? 4.36216   18.81750  -39.04543 1.000 37.11488 ? 245 ASP A CA  1 
ATOM   1895 C  C   . ASP A 1 245 ? 4.95533   17.98923  -37.91299 1.000 37.34952 ? 245 ASP A C   1 
ATOM   1896 O  O   . ASP A 1 245 ? 5.30449   18.52215  -36.85331 1.000 41.13665 ? 245 ASP A O   1 
ATOM   1897 C  CB  . ASP A 1 245 ? 2.84578   18.62535  -39.11527 1.000 43.83359 ? 245 ASP A CB  1 
ATOM   1898 C  CG  . ASP A 1 245 ? 2.11648   19.88069  -39.55200 1.000 48.92909 ? 245 ASP A CG  1 
ATOM   1899 O  OD1 . ASP A 1 245 ? 2.68895   20.98424  -39.41444 1.000 56.97870 ? 245 ASP A OD1 1 
ATOM   1900 O  OD2 . ASP A 1 245 ? 0.96527   19.76547  -40.01846 1.000 57.02648 ? 245 ASP A OD2 1 
ATOM   1901 N  N   . HIS A 1 246 ? 5.07593   16.67584  -38.12415 1.000 35.16437 ? 246 HIS A N   1 
ATOM   1902 C  CA  . HIS A 1 246 ? 5.69858   15.81370  -37.12540 1.000 38.39885 ? 246 HIS A CA  1 
ATOM   1903 C  C   . HIS A 1 246 ? 7.13945   16.23217  -36.85870 1.000 38.11049 ? 246 HIS A C   1 
ATOM   1904 O  O   . HIS A 1 246 ? 7.58670   16.24729  -35.70573 1.000 32.86324 ? 246 HIS A O   1 
ATOM   1905 C  CB  . HIS A 1 246 ? 5.64221   14.35727  -37.58606 1.000 34.75987 ? 246 HIS A CB  1 
ATOM   1906 C  CG  . HIS A 1 246 ? 4.25622   13.79548  -37.65763 1.000 39.68764 ? 246 HIS A CG  1 
ATOM   1907 N  ND1 . HIS A 1 246 ? 3.91307   12.76703  -38.50924 1.000 35.03613 ? 246 HIS A ND1 1 
ATOM   1908 C  CD2 . HIS A 1 246 ? 3.12920   14.11254  -36.97723 1.000 35.98810 ? 246 HIS A CD2 1 
ATOM   1909 C  CE1 . HIS A 1 246 ? 2.63282   12.47974  -38.35502 1.000 37.86790 ? 246 HIS A CE1 1 
ATOM   1910 N  NE2 . HIS A 1 246 ? 2.13433   13.28092  -37.43049 1.000 36.22597 ? 246 HIS A NE2 1 
ATOM   1911 N  N   . VAL A 1 247 ? 7.88059   16.57580  -37.91466 1.000 35.52785 ? 247 VAL A N   1 
ATOM   1912 C  CA  . VAL A 1 247 ? 9.25540   17.03591  -37.74246 1.000 37.66623 ? 247 VAL A CA  1 
ATOM   1913 C  C   . VAL A 1 247 ? 9.29493   18.28670  -36.87338 1.000 42.12010 ? 247 VAL A C   1 
ATOM   1914 O  O   . VAL A 1 247 ? 10.20975  18.47035  -36.06052 1.000 37.80722 ? 247 VAL A O   1 
ATOM   1915 C  CB  . VAL A 1 247 ? 9.90638   17.27479  -39.11683 1.000 39.59111 ? 247 VAL A CB  1 
ATOM   1916 C  CG1 . VAL A 1 247 ? 11.26137  17.95529  -38.96262 1.000 31.95359 ? 247 VAL A CG1 1 
ATOM   1917 C  CG2 . VAL A 1 247 ? 10.04331  15.95989  -39.86925 1.000 40.75456 ? 247 VAL A CG2 1 
ATOM   1918 N  N   . ASP A 1 248 ? 8.28949   19.15133  -37.00870 1.000 40.23965 ? 248 ASP A N   1 
ATOM   1919 C  CA  . ASP A 1 248 ? 8.29649   20.41492  -36.28215 1.000 40.69828 ? 248 ASP A CA  1 
ATOM   1920 C  C   . ASP A 1 248 ? 7.96096   20.23080  -34.80583 1.000 39.19517 ? 248 ASP A C   1 
ATOM   1921 O  O   . ASP A 1 248 ? 8.56152   20.88911  -33.94942 1.000 41.21094 ? 248 ASP A O   1 
ATOM   1922 C  CB  . ASP A 1 248 ? 7.32666   21.39888  -36.93794 1.000 46.97445 ? 248 ASP A CB  1 
ATOM   1923 C  CG  . ASP A 1 248 ? 7.76647   21.80734  -38.33122 1.000 40.97181 ? 248 ASP A CG  1 
ATOM   1924 O  OD1 . ASP A 1 248 ? 8.98672   21.78835  -38.60183 1.000 51.90554 ? 248 ASP A OD1 1 
ATOM   1925 O  OD2 . ASP A 1 248 ? 6.89217   22.14807  -39.15476 1.000 53.39589 ? 248 ASP A OD2 1 
ATOM   1926 N  N   . ILE A 1 249 ? 7.01336   19.34652  -34.48026 1.000 39.92182 ? 249 ILE A N   1 
ATOM   1927 C  CA  . ILE A 1 249 ? 6.64760   19.14260  -33.08119 1.000 42.46810 ? 249 ILE A CA  1 
ATOM   1928 C  C   . ILE A 1 249 ? 7.71201   18.38923  -32.30007 1.000 37.61571 ? 249 ILE A C   1 
ATOM   1929 O  O   . ILE A 1 249 ? 7.62975   18.32036  -31.06893 1.000 38.79129 ? 249 ILE A O   1 
ATOM   1930 C  CB  . ILE A 1 249 ? 5.29842   18.40511  -32.94842 1.000 42.96196 ? 249 ILE A CB  1 
ATOM   1931 C  CG1 . ILE A 1 249 ? 5.40577   16.97308  -33.47098 1.000 42.64824 ? 249 ILE A CG1 1 
ATOM   1932 C  CG2 . ILE A 1 249 ? 4.19539   19.17330  -33.66618 1.000 45.65181 ? 249 ILE A CG2 1 
ATOM   1933 C  CD1 . ILE A 1 249 ? 4.09532   16.21689  -33.42360 1.000 45.60809 ? 249 ILE A CD1 1 
ATOM   1934 N  N   . LEU A 1 250 ? 8.70709   17.82193  -32.97988 1.000 37.47133 ? 250 LEU A N   1 
ATOM   1935 C  CA  . LEU A 1 250 ? 9.83017   17.17408  -32.31687 1.000 38.84213 ? 250 LEU A CA  1 
ATOM   1936 C  C   . LEU A 1 250 ? 10.99928  18.11878  -32.07368 1.000 41.02905 ? 250 LEU A C   1 
ATOM   1937 O  O   . LEU A 1 250 ? 11.96287  17.72379  -31.40928 1.000 41.14370 ? 250 LEU A O   1 
ATOM   1938 C  CB  . LEU A 1 250 ? 10.30485  15.97095  -33.13687 1.000 33.06879 ? 250 LEU A CB  1 
ATOM   1939 C  CG  . LEU A 1 250 ? 9.35823   14.77066  -33.17324 1.000 34.25060 ? 250 LEU A CG  1 
ATOM   1940 C  CD1 . LEU A 1 250 ? 9.81360   13.75657  -34.21208 1.000 36.24920 ? 250 LEU A CD1 1 
ATOM   1941 C  CD2 . LEU A 1 250 ? 9.26839   14.12873  -31.79817 1.000 30.56053 ? 250 LEU A CD2 1 
ATOM   1942 N  N   . GLY A 1 251 ? 10.93180  19.34472  -32.59202 1.000 39.83785 ? 251 GLY A N   1 
ATOM   1943 C  CA  . GLY A 1 251 ? 11.97366  20.33311  -32.42817 1.000 39.98059 ? 251 GLY A CA  1 
ATOM   1944 C  C   . GLY A 1 251 ? 12.43611  20.54295  -30.99707 1.000 47.03946 ? 251 GLY A C   1 
ATOM   1945 O  O   . GLY A 1 251 ? 13.63866  20.53623  -30.71197 1.000 50.23942 ? 251 GLY A O   1 
ATOM   1946 N  N   . PRO A 1 252 ? 11.49507  20.76330  -30.06954 1.000 43.88129 ? 252 PRO A N   1 
ATOM   1947 C  CA  . PRO A 1 252 ? 11.88703  20.87982  -28.65322 1.000 39.05150 ? 252 PRO A CA  1 
ATOM   1948 C  C   . PRO A 1 252 ? 12.69512  19.69782  -28.14101 1.000 48.53529 ? 252 PRO A C   1 
ATOM   1949 O  O   . PRO A 1 252 ? 13.67047  19.89120  -27.40353 1.000 46.74435 ? 252 PRO A O   1 
ATOM   1950 C  CB  . PRO A 1 252 ? 10.53609  21.00202  -27.93854 1.000 44.19096 ? 252 PRO A CB  1 
ATOM   1951 C  CG  . PRO A 1 252 ? 9.66688   21.68093  -28.93611 1.000 38.87802 ? 252 PRO A CG  1 
ATOM   1952 C  CD  . PRO A 1 252 ? 10.08688  21.15045  -30.27935 1.000 38.35692 ? 252 PRO A CD  1 
ATOM   1953 N  N   . LEU A 1 253 ? 12.31619  18.47255  -28.51007 1.000 46.09511 ? 253 LEU A N   1 
ATOM   1954 C  CA  . LEU A 1 253 ? 13.10944  17.31524  -28.11162 1.000 47.30825 ? 253 LEU A CA  1 
ATOM   1955 C  C   . LEU A 1 253 ? 14.43183  17.26146  -28.86503 1.000 47.74623 ? 253 LEU A C   1 
ATOM   1956 O  O   . LEU A 1 253 ? 15.43627  16.78790  -28.32173 1.000 43.44632 ? 253 LEU A O   1 
ATOM   1957 C  CB  . LEU A 1 253 ? 12.31138  16.03025  -28.33077 1.000 40.32751 ? 253 LEU A CB  1 
ATOM   1958 C  CG  . LEU A 1 253 ? 11.06560  15.89202  -27.45406 1.000 45.53613 ? 253 LEU A CG  1 
ATOM   1959 C  CD1 . LEU A 1 253 ? 10.31046  14.61260  -27.77756 1.000 43.50900 ? 253 LEU A CD1 1 
ATOM   1960 C  CD2 . LEU A 1 253 ? 11.44748  15.93656  -25.98455 1.000 42.75635 ? 253 LEU A CD2 1 
ATOM   1961 N  N   . SER A 1 254 ? 14.45221  17.73944  -30.11003 1.000 43.50397 ? 254 SER A N   1 
ATOM   1962 C  CA  . SER A 1 254 ? 15.70263  17.79999  -30.85572 1.000 48.06806 ? 254 SER A CA  1 
ATOM   1963 C  C   . SER A 1 254 ? 16.63844  18.84473  -30.26435 1.000 50.15389 ? 254 SER A C   1 
ATOM   1964 O  O   . SER A 1 254 ? 17.84741  18.61176  -30.14821 1.000 44.33404 ? 254 SER A O   1 
ATOM   1965 C  CB  . SER A 1 254 ? 15.41830  18.10066  -32.32800 1.000 46.63580 ? 254 SER A CB  1 
ATOM   1966 O  OG  . SER A 1 254 ? 16.61331  18.11790  -33.08823 1.000 48.41150 ? 254 SER A OG  1 
ATOM   1967 N  N   . ALA A 1 255 ? 16.09395  19.99968  -29.87553 1.000 50.89422 ? 255 ALA A N   1 
ATOM   1968 C  CA  . ALA A 1 255 ? 16.92475  21.05770  -29.31480 1.000 49.54696 ? 255 ALA A CA  1 
ATOM   1969 C  C   . ALA A 1 255 ? 17.40027  20.71584  -27.90823 1.000 52.63958 ? 255 ALA A C   1 
ATOM   1970 O  O   . ALA A 1 255 ? 18.51149  21.09621  -27.52273 1.000 53.68707 ? 255 ALA A O   1 
ATOM   1971 C  CB  . ALA A 1 255 ? 16.15681  22.37962  -29.31319 1.000 41.99934 ? 255 ALA A CB  1 
ATOM   1972 N  N   . GLN A 1 256 ? 16.58226  20.00292  -27.12989 1.000 43.80498 ? 256 GLN A N   1 
ATOM   1973 C  CA  . GLN A 1 256 ? 16.97780  19.65919  -25.76807 1.000 44.37298 ? 256 GLN A CA  1 
ATOM   1974 C  C   . GLN A 1 256 ? 18.11440  18.64489  -25.74809 1.000 46.63331 ? 256 GLN A C   1 
ATOM   1975 O  O   . GLN A 1 256 ? 18.96872  18.69041  -24.85572 1.000 46.53297 ? 256 GLN A O   1 
ATOM   1976 C  CB  . GLN A 1 256 ? 15.77459  19.12357  -24.99321 1.000 46.30808 ? 256 GLN A CB  1 
ATOM   1977 C  CG  . GLN A 1 256 ? 16.08788  18.69837  -23.56662 1.000 52.30533 ? 256 GLN A CG  1 
ATOM   1978 C  CD  . GLN A 1 256 ? 14.88280  18.12307  -22.85367 1.000 61.04395 ? 256 GLN A CD  1 
ATOM   1979 O  OE1 . GLN A 1 256 ? 13.75362  18.22543  -23.33548 1.000 62.35127 ? 256 GLN A OE1 1 
ATOM   1980 N  NE2 . GLN A 1 256 ? 15.11673  17.50925  -21.69994 1.000 59.54241 ? 256 GLN A NE2 1 
ATOM   1981 N  N   . THR A 1 257 ? 18.14837  17.73262  -26.71797 1.000 50.25922 ? 257 THR A N   1 
ATOM   1982 C  CA  . THR A 1 257 ? 19.16261  16.68974  -26.76418 1.000 42.53995 ? 257 THR A CA  1 
ATOM   1983 C  C   . THR A 1 257 ? 20.26936  16.96829  -27.77172 1.000 46.19987 ? 257 THR A C   1 
ATOM   1984 O  O   . THR A 1 257 ? 21.29038  16.27439  -27.74809 1.000 47.51130 ? 257 THR A O   1 
ATOM   1985 C  CB  . THR A 1 257 ? 18.51846  15.33635  -27.09105 1.000 43.58027 ? 257 THR A CB  1 
ATOM   1986 O  OG1 . THR A 1 257 ? 17.94242  15.38515  -28.40124 1.000 43.60659 ? 257 THR A OG1 1 
ATOM   1987 C  CG2 . THR A 1 257 ? 17.42977  15.00657  -26.08289 1.000 39.13369 ? 257 THR A CG2 1 
ATOM   1988 N  N   . GLY A 1 258 ? 20.09773  17.95354  -28.65060 1.000 49.56966 ? 258 GLY A N   1 
ATOM   1989 C  CA  . GLY A 1 258 ? 21.09991  18.21798  -29.66379 1.000 41.69715 ? 258 GLY A CA  1 
ATOM   1990 C  C   . GLY A 1 258 ? 21.17834  17.18270  -30.76119 1.000 48.19052 ? 258 GLY A C   1 
ATOM   1991 O  O   . GLY A 1 258 ? 22.20177  17.09383  -31.44466 1.000 50.52842 ? 258 GLY A O   1 
ATOM   1992 N  N   . ILE A 1 259 ? 20.12540  16.39188  -30.94882 1.000 44.38648 ? 259 ILE A N   1 
ATOM   1993 C  CA  . ILE A 1 259 ? 20.07070  15.36242  -31.98032 1.000 38.98286 ? 259 ILE A CA  1 
ATOM   1994 C  C   . ILE A 1 259 ? 18.99015  15.76134  -32.97469 1.000 43.60529 ? 259 ILE A C   1 
ATOM   1995 O  O   . ILE A 1 259 ? 17.81088  15.86814  -32.61176 1.000 39.53302 ? 259 ILE A O   1 
ATOM   1996 C  CB  . ILE A 1 259 ? 19.78998  13.97504  -31.38350 1.000 41.72115 ? 259 ILE A CB  1 
ATOM   1997 C  CG1 . ILE A 1 259 ? 20.87667  13.60194  -30.37336 1.000 46.10024 ? 259 ILE A CG1 1 
ATOM   1998 C  CG2 . ILE A 1 259 ? 19.69211  12.92778  -32.48311 1.000 33.72733 ? 259 ILE A CG2 1 
ATOM   1999 C  CD1 . ILE A 1 259 ? 20.61995  12.29821  -29.64910 1.000 40.83973 ? 259 ILE A CD1 1 
ATOM   2000 N  N   . ALA A 1 260 ? 19.39230  15.98648  -34.22387 1.000 35.82578 ? 260 ALA A N   1 
ATOM   2001 C  CA  . ALA A 1 260 ? 18.45188  16.41723  -35.24802 1.000 40.51427 ? 260 ALA A CA  1 
ATOM   2002 C  C   . ALA A 1 260 ? 17.40098  15.34160  -35.50166 1.000 42.27951 ? 260 ALA A C   1 
ATOM   2003 O  O   . ALA A 1 260 ? 17.65873  14.14233  -35.36012 1.000 38.19862 ? 260 ALA A O   1 
ATOM   2004 C  CB  . ALA A 1 260 ? 19.19150  16.74795  -36.54395 1.000 38.14342 ? 260 ALA A CB  1 
ATOM   2005 N  N   . VAL A 1 261 ? 16.20105  15.79004  -35.88360 1.000 38.02338 ? 261 VAL A N   1 
ATOM   2006 C  CA  . VAL A 1 261 ? 15.08230  14.87250  -36.09392 1.000 40.14230 ? 261 VAL A CA  1 
ATOM   2007 C  C   . VAL A 1 261 ? 15.42807  13.83213  -37.15182 1.000 34.76720 ? 261 VAL A C   1 
ATOM   2008 O  O   . VAL A 1 261 ? 15.15570  12.63730  -36.98118 1.000 34.89788 ? 261 VAL A O   1 
ATOM   2009 C  CB  . VAL A 1 261 ? 13.81147  15.65923  -36.46681 1.000 40.86975 ? 261 VAL A CB  1 
ATOM   2010 C  CG1 . VAL A 1 261 ? 12.67789  14.70757  -36.81516 1.000 30.34341 ? 261 VAL A CG1 1 
ATOM   2011 C  CG2 . VAL A 1 261 ? 13.40612  16.58776  -35.32741 1.000 35.46824 ? 261 VAL A CG2 1 
ATOM   2012 N  N   . LEU A 1 262 ? 16.03809  14.26397  -38.25685 1.000 34.82347 ? 262 LEU A N   1 
ATOM   2013 C  CA  . LEU A 1 262 ? 16.42012  13.32464  -39.30441 1.000 36.95729 ? 262 LEU A CA  1 
ATOM   2014 C  C   . LEU A 1 262 ? 17.57893  12.42744  -38.88611 1.000 35.13758 ? 262 LEU A C   1 
ATOM   2015 O  O   . LEU A 1 262 ? 17.76652  11.36085  -39.48116 1.000 36.42952 ? 262 LEU A O   1 
ATOM   2016 C  CB  . LEU A 1 262 ? 16.76430  14.08290  -40.58537 1.000 34.88079 ? 262 LEU A CB  1 
ATOM   2017 C  CG  . LEU A 1 262 ? 15.55086  14.67293  -41.30887 1.000 41.96120 ? 262 LEU A CG  1 
ATOM   2018 C  CD1 . LEU A 1 262 ? 15.98459  15.52279  -42.48903 1.000 33.27673 ? 262 LEU A CD1 1 
ATOM   2019 C  CD2 . LEU A 1 262 ? 14.61387  13.56195  -41.76284 1.000 37.95718 ? 262 LEU A CD2 1 
ATOM   2020 N  N   . ASP A 1 263 ? 18.35457  12.82751  -37.87763 1.000 33.50886 ? 263 ASP A N   1 
ATOM   2021 C  CA  . ASP A 1 263 ? 19.35625  11.92253  -37.32509 1.000 38.17690 ? 263 ASP A CA  1 
ATOM   2022 C  C   . ASP A 1 263 ? 18.69662  10.80946  -36.52210 1.000 38.63686 ? 263 ASP A C   1 
ATOM   2023 O  O   . ASP A 1 263 ? 19.08782  9.64074   -36.62957 1.000 35.63046 ? 263 ASP A O   1 
ATOM   2024 C  CB  . ASP A 1 263 ? 20.34869  12.69539  -36.45657 1.000 38.70695 ? 263 ASP A CB  1 
ATOM   2025 C  CG  . ASP A 1 263 ? 21.27702  13.57477  -37.26889 1.000 43.07733 ? 263 ASP A CG  1 
ATOM   2026 O  OD1 . ASP A 1 263 ? 21.19093  13.55201  -38.51511 1.000 42.16451 ? 263 ASP A OD1 1 
ATOM   2027 O  OD2 . ASP A 1 263 ? 22.09957  14.28859  -36.65761 1.000 42.33783 ? 263 ASP A OD2 1 
ATOM   2028 N  N   . MET A 1 264 ? 17.68960  11.15336  -35.71443 1.000 34.83628 ? 264 MET A N   1 
ATOM   2029 C  CA  . MET A 1 264 ? 16.95907  10.13259  -34.97274 1.000 34.54155 ? 264 MET A CA  1 
ATOM   2030 C  C   . MET A 1 264 ? 16.17635  9.22089   -35.90772 1.000 33.46247 ? 264 MET A C   1 
ATOM   2031 O  O   . MET A 1 264 ? 16.01108  8.03100   -35.61545 1.000 34.11781 ? 264 MET A O   1 
ATOM   2032 C  CB  . MET A 1 264 ? 16.02544  10.78698  -33.95460 1.000 36.01141 ? 264 MET A CB  1 
ATOM   2033 C  CG  . MET A 1 264 ? 15.44998  9.81820   -32.93647 1.000 34.21678 ? 264 MET A CG  1 
ATOM   2034 S  SD  . MET A 1 264 ? 16.69979  9.15920   -31.80930 1.000 35.05826 ? 264 MET A SD  1 
ATOM   2035 C  CE  . MET A 1 264 ? 16.97630  10.56893  -30.73920 1.000 31.74759 ? 264 MET A CE  1 
ATOM   2036 N  N   . CYS A 1 265 ? 15.69432  9.75501   -37.03369 1.000 32.94038 ? 265 CYS A N   1 
ATOM   2037 C  CA  . CYS A 1 265 ? 15.06966  8.90726   -38.04363 1.000 33.56136 ? 265 CYS A CA  1 
ATOM   2038 C  C   . CYS A 1 265 ? 16.05170  7.88576   -38.59805 1.000 34.71693 ? 265 CYS A C   1 
ATOM   2039 O  O   . CYS A 1 265 ? 15.65117  6.77201   -38.95771 1.000 32.06203 ? 265 CYS A O   1 
ATOM   2040 C  CB  . CYS A 1 265 ? 14.50442  9.76245   -39.17678 1.000 31.49639 ? 265 CYS A CB  1 
ATOM   2041 S  SG  . CYS A 1 265 ? 13.14421  10.83983  -38.69256 1.000 36.63419 ? 265 CYS A SG  1 
ATOM   2042 N  N   . ALA A 1 266 ? 17.33584  8.24607   -38.67966 1.000 28.96362 ? 266 ALA A N   1 
ATOM   2043 C  CA  . ALA A 1 266 ? 18.34841  7.29065   -39.11898 1.000 29.36831 ? 266 ALA A CA  1 
ATOM   2044 C  C   . ALA A 1 266 ? 18.55583  6.18970   -38.08587 1.000 28.74615 ? 266 ALA A C   1 
ATOM   2045 O  O   . ALA A 1 266 ? 18.79010  5.03056   -38.44544 1.000 32.52465 ? 266 ALA A O   1 
ATOM   2046 C  CB  . ALA A 1 266 ? 19.66578  8.01177   -39.40659 1.000 31.87522 ? 266 ALA A CB  1 
ATOM   2047 N  N   . SER A 1 267 ? 18.47933  6.53151   -36.79810 1.000 32.69513 ? 267 SER A N   1 
ATOM   2048 C  CA  . SER A 1 267 ? 18.57621  5.51425   -35.75636 1.000 32.79222 ? 267 SER A CA  1 
ATOM   2049 C  C   . SER A 1 267 ? 17.39238  4.55694   -35.81643 1.000 31.18979 ? 267 SER A C   1 
ATOM   2050 O  O   . SER A 1 267 ? 17.56034  3.33559   -35.72219 1.000 29.00561 ? 267 SER A O   1 
ATOM   2051 C  CB  . SER A 1 267 ? 18.66420  6.17779   -34.38086 1.000 38.51794 ? 267 SER A CB  1 
ATOM   2052 O  OG  . SER A 1 267 ? 19.84225  6.95567   -34.26526 1.000 52.51872 ? 267 SER A OG  1 
ATOM   2053 N  N   . LEU A 1 268 ? 16.18114  5.09893   -35.97136 1.000 34.10691 ? 268 LEU A N   1 
ATOM   2054 C  CA  . LEU A 1 268 ? 14.99324  4.25397   -36.05542 1.000 30.30934 ? 268 LEU A CA  1 
ATOM   2055 C  C   . LEU A 1 268 ? 15.05915  3.32302   -37.26022 1.000 27.77609 ? 268 LEU A C   1 
ATOM   2056 O  O   . LEU A 1 268 ? 14.71043  2.14109   -37.15738 1.000 33.39211 ? 268 LEU A O   1 
ATOM   2057 C  CB  . LEU A 1 268 ? 13.73378  5.11998   -36.11638 1.000 30.46342 ? 268 LEU A CB  1 
ATOM   2058 C  CG  . LEU A 1 268 ? 12.42071  4.36200   -36.31675 1.000 31.94216 ? 268 LEU A CG  1 
ATOM   2059 C  CD1 . LEU A 1 268 ? 12.19255  3.38036   -35.17479 1.000 28.44972 ? 268 LEU A CD1 1 
ATOM   2060 C  CD2 . LEU A 1 268 ? 11.25167  5.32886   -36.44810 1.000 27.10211 ? 268 LEU A CD2 1 
ATOM   2061 N  N   . LYS A 1 269 ? 15.49956  3.83927   -38.41270 1.000 25.40731 ? 269 LYS A N   1 
ATOM   2062 C  CA  . LYS A 1 269 ? 15.67325  2.99518   -39.59271 1.000 27.54330 ? 269 LYS A CA  1 
ATOM   2063 C  C   . LYS A 1 269 ? 16.56807  1.80198   -39.29130 1.000 32.18668 ? 269 LYS A C   1 
ATOM   2064 O  O   . LYS A 1 269 ? 16.28717  0.67789   -39.72421 1.000 32.28215 ? 269 LYS A O   1 
ATOM   2065 C  CB  . LYS A 1 269 ? 16.25802  3.81450   -40.74675 1.000 36.99632 ? 269 LYS A CB  1 
ATOM   2066 C  CG  . LYS A 1 269 ? 15.25329  4.69420   -41.47092 1.000 40.63954 ? 269 LYS A CG  1 
ATOM   2067 C  CD  . LYS A 1 269 ? 15.93753  5.69899   -42.39506 1.000 39.71621 ? 269 LYS A CD  1 
ATOM   2068 C  CE  . LYS A 1 269 ? 16.66155  5.01580   -43.54205 1.000 30.42307 ? 269 LYS A CE  1 
ATOM   2069 N  NZ  . LYS A 1 269 ? 17.26672  6.00859   -44.48076 1.000 39.34750 ? 269 LYS A NZ  1 
ATOM   2070 N  N   . GLU A 1 270 ? 17.64618  2.02939   -38.53520 1.000 30.97822 ? 270 GLU A N   1 
ATOM   2071 C  CA  . GLU A 1 270 ? 18.57707  0.95400   -38.20814 1.000 33.16235 ? 270 GLU A CA  1 
ATOM   2072 C  C   . GLU A 1 270 ? 17.98563  -0.00238  -37.17850 1.000 33.00068 ? 270 GLU A C   1 
ATOM   2073 O  O   . GLU A 1 270 ? 18.22481  -1.21461  -37.24209 1.000 36.01120 ? 270 GLU A O   1 
ATOM   2074 C  CB  . GLU A 1 270 ? 19.89387  1.54947   -37.70846 1.000 32.93121 ? 270 GLU A CB  1 
ATOM   2075 C  CG  . GLU A 1 270 ? 20.88834  0.54183   -37.16542 1.000 33.50412 ? 270 GLU A CG  1 
ATOM   2076 C  CD  . GLU A 1 270 ? 22.27069  1.14015   -36.99274 1.000 35.99111 ? 270 GLU A CD  1 
ATOM   2077 O  OE1 . GLU A 1 270 ? 22.94887  1.37166   -38.01708 1.000 32.92188 ? 270 GLU A OE1 1 
ATOM   2078 O  OE2 . GLU A 1 270 ? 22.67067  1.39554   -35.83740 1.000 35.87789 ? 270 GLU A OE2 1 
ATOM   2079 N  N   . LEU A 1 271 ? 17.21714  0.52268   -36.21919 1.000 31.81014 ? 271 LEU A N   1 
ATOM   2080 C  CA  . LEU A 1 271 ? 16.54211  -0.34105  -35.25271 1.000 30.49324 ? 271 LEU A CA  1 
ATOM   2081 C  C   . LEU A 1 271 ? 15.54188  -1.26383  -35.93823 1.000 31.48135 ? 271 LEU A C   1 
ATOM   2082 O  O   . LEU A 1 271 ? 15.44364  -2.44842  -35.59641 1.000 33.93285 ? 271 LEU A O   1 
ATOM   2083 C  CB  . LEU A 1 271 ? 15.84284  0.50450   -34.18852 1.000 28.91495 ? 271 LEU A CB  1 
ATOM   2084 C  CG  . LEU A 1 271 ? 16.68436  1.04735   -33.03327 1.000 36.32936 ? 271 LEU A CG  1 
ATOM   2085 C  CD1 . LEU A 1 271 ? 15.95892  2.18993   -32.34638 1.000 28.77278 ? 271 LEU A CD1 1 
ATOM   2086 C  CD2 . LEU A 1 271 ? 17.00073  -0.06105  -32.03673 1.000 30.01614 ? 271 LEU A CD2 1 
ATOM   2087 N  N   . LEU A 1 272 ? 14.78309  -0.73579  -36.90309 1.000 28.28770 ? 272 LEU A N   1 
ATOM   2088 C  CA  . LEU A 1 272 ? 13.84956  -1.56955  -37.65444 1.000 32.12828 ? 272 LEU A CA  1 
ATOM   2089 C  C   . LEU A 1 272 ? 14.57903  -2.64287  -38.44864 1.000 37.33553 ? 272 LEU A C   1 
ATOM   2090 O  O   . LEU A 1 272 ? 14.02958  -3.72376  -38.69068 1.000 37.45497 ? 272 LEU A O   1 
ATOM   2091 C  CB  . LEU A 1 272 ? 13.01226  -0.70100  -38.59214 1.000 27.72031 ? 272 LEU A CB  1 
ATOM   2092 C  CG  . LEU A 1 272 ? 12.09696  0.31796   -37.91511 1.000 33.48517 ? 272 LEU A CG  1 
ATOM   2093 C  CD1 . LEU A 1 272 ? 11.56288  1.31815   -38.92192 1.000 31.23596 ? 272 LEU A CD1 1 
ATOM   2094 C  CD2 . LEU A 1 272 ? 10.95540  -0.39961  -37.22464 1.000 28.86774 ? 272 LEU A CD2 1 
ATOM   2095 N  N   . GLN A 1 273 ? 15.81598  -2.36308  -38.85591 1.000 33.58519 ? 273 GLN A N   1 
ATOM   2096 C  CA  . GLN A 1 273 ? 16.59330  -3.30942  -39.64444 1.000 28.68215 ? 273 GLN A CA  1 
ATOM   2097 C  C   . GLN A 1 273 ? 17.27538  -4.35343  -38.76660 1.000 32.64254 ? 273 GLN A C   1 
ATOM   2098 O  O   . GLN A 1 273 ? 17.34828  -5.52939  -39.14162 1.000 36.51973 ? 273 GLN A O   1 
ATOM   2099 C  CB  . GLN A 1 273 ? 17.61819  -2.54187  -40.48026 1.000 30.53561 ? 273 GLN A CB  1 
ATOM   2100 C  CG  . GLN A 1 273 ? 18.87284  -3.30934  -40.83653 1.000 34.00868 ? 273 GLN A CG  1 
ATOM   2101 C  CD  . GLN A 1 273 ? 19.98968  -2.38892  -41.29440 1.000 33.40428 ? 273 GLN A CD  1 
ATOM   2102 O  OE1 . GLN A 1 273 ? 19.89599  -1.75542  -42.34262 1.000 34.97145 ? 273 GLN A OE1 1 
ATOM   2103 N  NE2 . GLN A 1 273 ? 21.04744  -2.30145  -40.49950 1.000 30.58398 ? 273 GLN A NE2 1 
ATOM   2104 N  N   . ASN A 1 274 ? 17.76407  -3.95102  -37.59159 1.000 31.10116 ? 274 ASN A N   1 
ATOM   2105 C  CA  . ASN A 1 274 ? 18.52887  -4.84536  -36.73160 1.000 39.65741 ? 274 ASN A CA  1 
ATOM   2106 C  C   . ASN A 1 274 ? 17.70953  -5.47816  -35.61592 1.000 44.39873 ? 274 ASN A C   1 
ATOM   2107 O  O   . ASN A 1 274 ? 18.09420  -6.54196  -35.11813 1.000 38.13415 ? 274 ASN A O   1 
ATOM   2108 C  CB  . ASN A 1 274 ? 19.71069  -4.09978  -36.09617 1.000 29.93936 ? 274 ASN A CB  1 
ATOM   2109 C  CG  . ASN A 1 274 ? 20.70345  -3.60076  -37.11946 1.000 34.51027 ? 274 ASN A CG  1 
ATOM   2110 O  OD1 . ASN A 1 274 ? 20.65925  -3.99318  -38.28452 1.000 37.27695 ? 274 ASN A OD1 1 
ATOM   2111 N  ND2 . ASN A 1 274 ? 21.61572  -2.73729  -36.68758 1.000 39.79969 ? 274 ASN A ND2 1 
ATOM   2112 N  N   . GLY A 1 275 ? 16.60548  -4.86112  -35.20942 1.000 36.15407 ? 275 GLY A N   1 
ATOM   2113 C  CA  . GLY A 1 275 ? 15.92513  -5.31427  -34.01823 1.000 34.49122 ? 275 GLY A CA  1 
ATOM   2114 C  C   . GLY A 1 275 ? 16.67159  -4.86190  -32.77016 1.000 41.01520 ? 275 GLY A C   1 
ATOM   2115 O  O   . GLY A 1 275 ? 17.58329  -4.03373  -32.80925 1.000 39.53035 ? 275 GLY A O   1 
ATOM   2116 N  N   . MET A 1 276 ? 16.26745  -5.43870  -31.64094 1.000 44.06863 ? 276 MET A N   1 
ATOM   2117 C  CA  . MET A 1 276 ? 16.83590  -5.05556  -30.35553 1.000 51.99790 ? 276 MET A CA  1 
ATOM   2118 C  C   . MET A 1 276 ? 18.11214  -5.80975  -30.01038 1.000 46.46026 ? 276 MET A C   1 
ATOM   2119 O  O   . MET A 1 276 ? 18.92677  -5.29013  -29.23881 1.000 42.62205 ? 276 MET A O   1 
ATOM   2120 C  CB  . MET A 1 276 ? 15.80863  -5.27046  -29.23815 1.000 50.26712 ? 276 MET A CB  1 
ATOM   2121 C  CG  . MET A 1 276 ? 14.57583  -4.39158  -29.34861 1.000 46.84010 ? 276 MET A CG  1 
ATOM   2122 S  SD  . MET A 1 276 ? 14.96732  -2.64076  -29.19609 1.000 56.46735 ? 276 MET A SD  1 
ATOM   2123 C  CE  . MET A 1 276 ? 13.80877  -2.14624  -27.92672 1.000 40.63935 ? 276 MET A CE  1 
ATOM   2124 N  N   . ASN A 1 277 ? 18.30048  -7.01138  -30.55671 1.000 50.05247 ? 277 ASN A N   1 
ATOM   2125 C  CA  . ASN A 1 277 ? 19.45779  -7.85509  -30.25310 1.000 49.08185 ? 277 ASN A CA  1 
ATOM   2126 C  C   . ASN A 1 277 ? 19.59508  -8.07909  -28.74766 1.000 50.57132 ? 277 ASN A C   1 
ATOM   2127 O  O   . ASN A 1 277 ? 20.65873  -7.88523  -28.15469 1.000 46.88288 ? 277 ASN A O   1 
ATOM   2128 C  CB  . ASN A 1 277 ? 20.74128  -7.26661  -30.84396 1.000 46.31046 ? 277 ASN A CB  1 
ATOM   2129 C  CG  . ASN A 1 277 ? 20.76986  -7.33541  -32.36097 1.000 61.25999 ? 277 ASN A CG  1 
ATOM   2130 O  OD1 . ASN A 1 277 ? 20.99628  -6.33001  -33.03760 1.000 48.03714 ? 277 ASN A OD1 1 
ATOM   2131 N  ND2 . ASN A 1 277 ? 20.53828  -8.52749  -32.90334 1.000 51.58186 ? 277 ASN A ND2 1 
ATOM   2132 N  N   . GLY A 1 278 ? 18.48940  -8.48869  -28.12458 1.000 48.65433 ? 278 GLY A N   1 
ATOM   2133 C  CA  . GLY A 1 278 ? 18.47004  -8.81222  -26.71368 1.000 42.59802 ? 278 GLY A CA  1 
ATOM   2134 C  C   . GLY A 1 278 ? 18.47356  -7.63209  -25.76664 1.000 46.24781 ? 278 GLY A C   1 
ATOM   2135 O  O   . GLY A 1 278 ? 18.34392  -7.83597  -24.55228 1.000 51.10193 ? 278 GLY A O   1 
ATOM   2136 N  N   . ARG A 1 279 ? 18.61640  -6.40909  -26.26788 1.000 50.73262 ? 279 ARG A N   1 
ATOM   2137 C  CA  . ARG A 1 279 ? 18.65483  -5.23380  -25.41524 1.000 43.21977 ? 279 ARG A CA  1 
ATOM   2138 C  C   . ARG A 1 279 ? 17.24779  -4.66514  -25.23144 1.000 43.04414 ? 279 ARG A C   1 
ATOM   2139 O  O   . ARG A 1 279 ? 16.27254  -5.13571  -25.82165 1.000 48.16119 ? 279 ARG A O   1 
ATOM   2140 C  CB  . ARG A 1 279 ? 19.60820  -4.19000  -25.99695 1.000 44.68885 ? 279 ARG A CB  1 
ATOM   2141 C  CG  . ARG A 1 279 ? 21.06487  -4.63284  -26.03390 1.000 45.89267 ? 279 ARG A CG  1 
ATOM   2142 C  CD  . ARG A 1 279 ? 21.95965  -3.56058  -26.62840 1.000 40.82602 ? 279 ARG A CD  1 
ATOM   2143 N  NE  . ARG A 1 279 ? 21.78002  -3.43617  -28.07013 1.000 57.22299 ? 279 ARG A NE  1 
ATOM   2144 C  CZ  . ARG A 1 279 ? 22.61001  -3.93607  -28.97644 1.000 58.93886 ? 279 ARG A CZ  1 
ATOM   2145 N  NH1 . ARG A 1 279 ? 23.69401  -4.60939  -28.62553 1.000 54.49038 ? 279 ARG A NH1 1 
ATOM   2146 N  NH2 . ARG A 1 279 ? 22.34836  -3.75229  -30.26755 1.000 41.77233 ? 279 ARG A NH2 1 
ATOM   2147 N  N   . THR A 1 280 ? 17.13793  -3.64425  -24.38587 1.000 41.41772 ? 280 THR A N   1 
ATOM   2148 C  CA  . THR A 1 280 ? 15.87485  -2.96985  -24.13663 1.000 42.03106 ? 280 THR A CA  1 
ATOM   2149 C  C   . THR A 1 280 ? 16.08412  -1.46438  -24.19706 1.000 41.83771 ? 280 THR A C   1 
ATOM   2150 O  O   . THR A 1 280 ? 17.20180  -0.96136  -24.05869 1.000 34.49051 ? 280 THR A O   1 
ATOM   2151 C  CB  . THR A 1 280 ? 15.27134  -3.34712  -22.77113 1.000 39.20751 ? 280 THR A CB  1 
ATOM   2152 O  OG1 . THR A 1 280 ? 16.16518  -2.94924  -21.72494 1.000 39.98084 ? 280 THR A OG1 1 
ATOM   2153 C  CG2 . THR A 1 280 ? 15.01783  -4.84761  -22.68184 1.000 36.12811 ? 280 THR A CG2 1 
ATOM   2154 N  N   . ILE A 1 281 ? 14.98475  -0.74913  -24.41087 1.000 42.49059 ? 281 ILE A N   1 
ATOM   2155 C  CA  . ILE A 1 281 ? 14.96594  0.70692   -24.37883 1.000 42.19958 ? 281 ILE A CA  1 
ATOM   2156 C  C   . ILE A 1 281 ? 13.86688  1.12253   -23.41427 1.000 40.79225 ? 281 ILE A C   1 
ATOM   2157 O  O   . ILE A 1 281 ? 12.69561  0.79138   -23.62978 1.000 39.35957 ? 281 ILE A O   1 
ATOM   2158 C  CB  . ILE A 1 281 ? 14.72941  1.31592   -25.77015 1.000 44.57245 ? 281 ILE A CB  1 
ATOM   2159 C  CG1 . ILE A 1 281 ? 15.85506  0.92529   -26.72865 1.000 37.21020 ? 281 ILE A CG1 1 
ATOM   2160 C  CG2 . ILE A 1 281 ? 14.60875  2.82509   -25.67446 1.000 39.17727 ? 281 ILE A CG2 1 
ATOM   2161 C  CD1 . ILE A 1 281 ? 15.66705  1.45840   -28.13128 1.000 37.82633 ? 281 ILE A CD1 1 
ATOM   2162 N  N   . LEU A 1 282 ? 14.24574  1.82777   -22.34709 1.000 42.79887 ? 282 LEU A N   1 
ATOM   2163 C  CA  . LEU A 1 282 ? 13.31220  2.23862   -21.29774 1.000 39.92578 ? 282 LEU A CA  1 
ATOM   2164 C  C   . LEU A 1 282 ? 12.50832  1.04760   -20.77878 1.000 49.02064 ? 282 LEU A C   1 
ATOM   2165 O  O   . LEU A 1 282 ? 11.29927  1.13291   -20.55208 1.000 44.13767 ? 282 LEU A O   1 
ATOM   2166 C  CB  . LEU A 1 282 ? 12.38954  3.35534   -21.78936 1.000 45.05048 ? 282 LEU A CB  1 
ATOM   2167 C  CG  . LEU A 1 282 ? 13.08977  4.64921   -22.21517 1.000 46.74062 ? 282 LEU A CG  1 
ATOM   2168 C  CD1 . LEU A 1 282 ? 12.08618  5.66818   -22.73659 1.000 41.48387 ? 282 LEU A CD1 1 
ATOM   2169 C  CD2 . LEU A 1 282 ? 13.90376  5.22862   -21.06239 1.000 37.93232 ? 282 LEU A CD2 1 
ATOM   2170 N  N   . GLY A 1 283 ? 13.19079  -0.08220  -20.60143 1.000 46.25394 ? 283 GLY A N   1 
ATOM   2171 C  CA  . GLY A 1 283 ? 12.57370  -1.27453  -20.05870 1.000 37.92026 ? 283 GLY A CA  1 
ATOM   2172 C  C   . GLY A 1 283 ? 11.68519  -2.04305  -21.00827 1.000 37.84930 ? 283 GLY A C   1 
ATOM   2173 O  O   . GLY A 1 283 ? 10.97543  -2.95223  -20.56360 1.000 50.35928 ? 283 GLY A O   1 
ATOM   2174 N  N   . SER A 1 284 ? 11.69787  -1.71767  -22.29739 1.000 44.05603 ? 284 SER A N   1 
ATOM   2175 C  CA  . SER A 1 284 ? 10.85675  -2.38198  -23.28211 1.000 40.16368 ? 284 SER A CA  1 
ATOM   2176 C  C   . SER A 1 284 ? 11.71870  -3.04008  -24.34972 1.000 38.70821 ? 284 SER A C   1 
ATOM   2177 O  O   . SER A 1 284 ? 12.70888  -2.46062  -24.80738 1.000 37.68306 ? 284 SER A O   1 
ATOM   2178 C  CB  . SER A 1 284 ? 9.88681   -1.39454  -23.93422 1.000 35.72250 ? 284 SER A CB  1 
ATOM   2179 O  OG  . SER A 1 284 ? 9.20897   -2.00107  -25.01850 1.000 44.08841 ? 284 SER A OG  1 
ATOM   2180 N  N   . ALA A 1 285 ? 11.33353  -4.25192  -24.74529 1.000 41.41988 ? 285 ALA A N   1 
ATOM   2181 C  CA  . ALA A 1 285 ? 12.02147  -4.98930  -25.79579 1.000 42.16825 ? 285 ALA A CA  1 
ATOM   2182 C  C   . ALA A 1 285 ? 11.43747  -4.72370  -27.17757 1.000 43.84300 ? 285 ALA A C   1 
ATOM   2183 O  O   . ALA A 1 285 ? 11.79356  -5.42126  -28.13336 1.000 52.22797 ? 285 ALA A O   1 
ATOM   2184 C  CB  . ALA A 1 285 ? 11.99311  -6.48990  -25.49678 1.000 40.25061 ? 285 ALA A CB  1 
ATOM   2185 N  N   . LEU A 1 286 ? 10.54370  -3.74422  -27.30231 1.000 38.67098 ? 286 LEU A N   1 
ATOM   2186 C  CA  . LEU A 1 286 ? 10.04595  -3.30571  -28.59777 1.000 44.05004 ? 286 LEU A CA  1 
ATOM   2187 C  C   . LEU A 1 286 ? 9.89449   -1.79065  -28.58268 1.000 38.78790 ? 286 LEU A C   1 
ATOM   2188 O  O   . LEU A 1 286 ? 10.02185  -1.13925  -27.54221 1.000 42.48611 ? 286 LEU A O   1 
ATOM   2189 C  CB  . LEU A 1 286 ? 8.72310   -3.99527  -28.97019 1.000 41.87308 ? 286 LEU A CB  1 
ATOM   2190 C  CG  . LEU A 1 286 ? 7.60117   -4.20209  -27.94694 1.000 48.74447 ? 286 LEU A CG  1 
ATOM   2191 C  CD1 . LEU A 1 286 ? 6.92258   -2.89591  -27.54982 1.000 52.94777 ? 286 LEU A CD1 1 
ATOM   2192 C  CD2 . LEU A 1 286 ? 6.58147   -5.18858  -28.50457 1.000 41.75821 ? 286 LEU A CD2 1 
ATOM   2193 N  N   . LEU A 1 287 ? 9.61976   -1.23143  -29.75698 1.000 27.53558 ? 287 LEU A N   1 
ATOM   2194 C  CA  . LEU A 1 287 ? 9.54387   0.21443   -29.91701 1.000 31.89747 ? 287 LEU A CA  1 
ATOM   2195 C  C   . LEU A 1 287 ? 8.14858   0.70275   -29.53812 1.000 41.01220 ? 287 LEU A C   1 
ATOM   2196 O  O   . LEU A 1 287 ? 7.15951   0.34845   -30.18965 1.000 34.81834 ? 287 LEU A O   1 
ATOM   2197 C  CB  . LEU A 1 287 ? 9.89357   0.59570   -31.35259 1.000 37.99344 ? 287 LEU A CB  1 
ATOM   2198 C  CG  . LEU A 1 287 ? 11.23163  0.01539   -31.82117 1.000 37.53667 ? 287 LEU A CG  1 
ATOM   2199 C  CD1 . LEU A 1 287 ? 11.46613  0.28695   -33.29734 1.000 32.73610 ? 287 LEU A CD1 1 
ATOM   2200 C  CD2 . LEU A 1 287 ? 12.36975  0.56925   -30.98047 1.000 30.49048 ? 287 LEU A CD2 1 
ATOM   2201 N  N   . GLU A 1 288 ? 8.07403   1.51401   -28.48542 1.000 41.33537 ? 288 GLU A N   1 
ATOM   2202 C  CA  . GLU A 1 288 ? 6.80073   1.99335   -27.96550 1.000 36.17471 ? 288 GLU A CA  1 
ATOM   2203 C  C   . GLU A 1 288 ? 6.28340   3.15776   -28.80170 1.000 40.04704 ? 288 GLU A C   1 
ATOM   2204 O  O   . GLU A 1 288 ? 7.04118   4.06120   -29.16824 1.000 33.86878 ? 288 GLU A O   1 
ATOM   2205 C  CB  . GLU A 1 288 ? 6.96037   2.42378   -26.50640 1.000 40.19610 ? 288 GLU A CB  1 
ATOM   2206 C  CG  . GLU A 1 288 ? 5.65184   2.75577   -25.81115 1.000 56.27055 ? 288 GLU A CG  1 
ATOM   2207 C  CD  . GLU A 1 288 ? 4.75377   1.54479   -25.66856 1.000 56.64995 ? 288 GLU A CD  1 
ATOM   2208 O  OE1 . GLU A 1 288 ? 5.27618   0.45448   -25.35289 1.000 54.80368 ? 288 GLU A OE1 1 
ATOM   2209 O  OE2 . GLU A 1 288 ? 3.52999   1.67889   -25.88336 1.000 53.92604 ? 288 GLU A OE2 1 
ATOM   2210 N  N   . ASP A 1 289 ? 4.97828   3.13649   -29.10401 1.000 36.70867 ? 289 ASP A N   1 
ATOM   2211 C  CA  . ASP A 1 289 ? 4.37929   4.16353   -29.95129 1.000 34.01376 ? 289 ASP A CA  1 
ATOM   2212 C  C   . ASP A 1 289 ? 3.15188   4.80993   -29.31488 1.000 35.29245 ? 289 ASP A C   1 
ATOM   2213 O  O   . ASP A 1 289 ? 2.36139   5.44647   -30.01926 1.000 31.52228 ? 289 ASP A O   1 
ATOM   2214 C  CB  . ASP A 1 289 ? 4.02257   3.59300   -31.32897 1.000 31.09813 ? 289 ASP A CB  1 
ATOM   2215 C  CG  . ASP A 1 289 ? 2.76437   2.74015   -31.31567 1.000 34.36066 ? 289 ASP A CG  1 
ATOM   2216 O  OD1 . ASP A 1 289 ? 2.38013   2.22380   -30.24434 1.000 31.85011 ? 289 ASP A OD1 1 
ATOM   2217 O  OD2 . ASP A 1 289 ? 2.16237   2.57879   -32.39801 1.000 31.02827 ? 289 ASP A OD2 1 
ATOM   2218 N  N   . GLU A 1 290 ? 2.97128   4.66879   -28.00293 1.000 30.91954 ? 290 GLU A N   1 
ATOM   2219 C  CA  . GLU A 1 290 ? 1.83959   5.27722   -27.31532 1.000 40.03775 ? 290 GLU A CA  1 
ATOM   2220 C  C   . GLU A 1 290 ? 2.29405   6.32087   -26.29769 1.000 34.30412 ? 290 GLU A C   1 
ATOM   2221 O  O   . GLU A 1 290 ? 1.66427   6.50073   -25.25382 1.000 37.88431 ? 290 GLU A O   1 
ATOM   2222 C  CB  . GLU A 1 290 ? 0.96591   4.20607   -26.66392 1.000 40.02367 ? 290 GLU A CB  1 
ATOM   2223 C  CG  . GLU A 1 290 ? 0.44660   3.17727   -27.66471 1.000 35.69340 ? 290 GLU A CG  1 
ATOM   2224 C  CD  . GLU A 1 290 ? -0.89631  2.58833   -27.27671 1.000 41.73117 ? 290 GLU A CD  1 
ATOM   2225 O  OE1 . GLU A 1 290 ? -1.20272  2.53135   -26.06840 1.000 37.67848 ? 290 GLU A OE1 1 
ATOM   2226 O  OE2 . GLU A 1 290 ? -1.65165  2.18473   -28.18906 1.000 43.82755 ? 290 GLU A OE2 1 
ATOM   2227 N  N   . PHE A 1 291 ? 3.39498   7.00869   -26.59755 1.000 33.06755 ? 291 PHE A N   1 
ATOM   2228 C  CA  . PHE A 1 291 ? 3.81929   8.21339   -25.89234 1.000 34.61106 ? 291 PHE A CA  1 
ATOM   2229 C  C   . PHE A 1 291 ? 3.92833   9.33391   -26.91626 1.000 33.73163 ? 291 PHE A C   1 
ATOM   2230 O  O   . PHE A 1 291 ? 4.71444   9.23314   -27.86330 1.000 34.72545 ? 291 PHE A O   1 
ATOM   2231 C  CB  . PHE A 1 291 ? 5.16547   8.01878   -25.18711 1.000 40.93995 ? 291 PHE A CB  1 
ATOM   2232 C  CG  . PHE A 1 291 ? 5.10882   7.12867   -23.97863 1.000 43.40015 ? 291 PHE A CG  1 
ATOM   2233 C  CD1 . PHE A 1 291 ? 4.66561   7.61742   -22.76142 1.000 48.77754 ? 291 PHE A CD1 1 
ATOM   2234 C  CD2 . PHE A 1 291 ? 5.52949   5.80991   -24.05252 1.000 52.63634 ? 291 PHE A CD2 1 
ATOM   2235 C  CE1 . PHE A 1 291 ? 4.62297   6.80164   -21.64435 1.000 59.60929 ? 291 PHE A CE1 1 
ATOM   2236 C  CE2 . PHE A 1 291 ? 5.49031   4.99005   -22.93988 1.000 52.96598 ? 291 PHE A CE2 1 
ATOM   2237 C  CZ  . PHE A 1 291 ? 5.03641   5.48657   -21.73443 1.000 55.51201 ? 291 PHE A CZ  1 
ATOM   2238 N  N   . THR A 1 292 ? 3.14726   10.39211  -26.73315 1.000 32.54550 ? 292 THR A N   1 
ATOM   2239 C  CA  . THR A 1 292 ? 3.18927   11.50560  -27.66537 1.000 34.73118 ? 292 THR A CA  1 
ATOM   2240 C  C   . THR A 1 292 ? 4.40448   12.38686  -27.39208 1.000 37.87945 ? 292 THR A C   1 
ATOM   2241 O  O   . THR A 1 292 ? 5.00859   12.31327  -26.31858 1.000 36.68694 ? 292 THR A O   1 
ATOM   2242 C  CB  . THR A 1 292 ? 1.91487   12.33778  -27.55778 1.000 29.64537 ? 292 THR A CB  1 
ATOM   2243 O  OG1 . THR A 1 292 ? 1.88132   12.99616  -26.28619 1.000 32.22820 ? 292 THR A OG1 1 
ATOM   2244 C  CG2 . THR A 1 292 ? 0.68709   11.45499  -27.70472 1.000 32.78032 ? 292 THR A CG2 1 
ATOM   2245 N  N   . PRO A 1 293 ? 4.79820   13.22080  -28.36035 1.000 34.16560 ? 293 PRO A N   1 
ATOM   2246 C  CA  . PRO A 1 293 ? 5.81221   14.24598  -28.06190 1.000 36.97361 ? 293 PRO A CA  1 
ATOM   2247 C  C   . PRO A 1 293 ? 5.42645   15.12586  -26.88752 1.000 44.73976 ? 293 PRO A C   1 
ATOM   2248 O  O   . PRO A 1 293 ? 6.29478   15.55674  -26.11858 1.000 46.80401 ? 293 PRO A O   1 
ATOM   2249 C  CB  . PRO A 1 293 ? 5.89355   15.04020  -29.37178 1.000 29.67514 ? 293 PRO A CB  1 
ATOM   2250 C  CG  . PRO A 1 293 ? 5.50399   14.06164  -30.42068 1.000 33.16232 ? 293 PRO A CG  1 
ATOM   2251 C  CD  . PRO A 1 293 ? 4.47104   13.16648  -29.79741 1.000 30.14434 ? 293 PRO A CD  1 
ATOM   2252 N  N   . PHE A 1 294 ? 4.12993   15.39875  -26.73140 1.000 48.79605 ? 294 PHE A N   1 
ATOM   2253 C  CA  . PHE A 1 294 ? 3.65371   16.16228  -25.58440 1.000 44.58947 ? 294 PHE A CA  1 
ATOM   2254 C  C   . PHE A 1 294 ? 3.86360   15.38792  -24.28849 1.000 43.30541 ? 294 PHE A C   1 
ATOM   2255 O  O   . PHE A 1 294 ? 4.33467   15.94535  -23.29067 1.000 42.31603 ? 294 PHE A O   1 
ATOM   2256 C  CB  . PHE A 1 294 ? 2.17666   16.51137  -25.78033 1.000 47.56872 ? 294 PHE A CB  1 
ATOM   2257 C  CG  . PHE A 1 294 ? 1.59677   17.35902  -24.68467 1.000 54.72415 ? 294 PHE A CG  1 
ATOM   2258 C  CD1 . PHE A 1 294 ? 1.66800   18.74157  -24.74992 1.000 61.03243 ? 294 PHE A CD1 1 
ATOM   2259 C  CD2 . PHE A 1 294 ? 0.96678   16.77538  -23.59661 1.000 56.77851 ? 294 PHE A CD2 1 
ATOM   2260 C  CE1 . PHE A 1 294 ? 1.12923   19.52632  -23.74441 1.000 63.01141 ? 294 PHE A CE1 1 
ATOM   2261 C  CE2 . PHE A 1 294 ? 0.42742   17.55410  -22.58717 1.000 57.89223 ? 294 PHE A CE2 1 
ATOM   2262 C  CZ  . PHE A 1 294 ? 0.50830   18.93092  -22.66182 1.000 58.72990 ? 294 PHE A CZ  1 
ATOM   2263 N  N   . ASP A 1 295 ? 3.51864   14.09615  -24.28744 1.000 41.39004 ? 295 ASP A N   1 
ATOM   2264 C  CA  . ASP A 1 295 ? 3.67931   13.28161  -23.08571 1.000 40.82721 ? 295 ASP A CA  1 
ATOM   2265 C  C   . ASP A 1 295 ? 5.14032   13.19633  -22.66423 1.000 48.93313 ? 295 ASP A C   1 
ATOM   2266 O  O   . ASP A 1 295 ? 5.44868   13.19119  -21.46640 1.000 47.76676 ? 295 ASP A O   1 
ATOM   2267 C  CB  . ASP A 1 295 ? 3.11921   11.87787  -23.31891 1.000 37.06394 ? 295 ASP A CB  1 
ATOM   2268 C  CG  . ASP A 1 295 ? 1.61795   11.86926  -23.49636 1.000 39.63576 ? 295 ASP A CG  1 
ATOM   2269 O  OD1 . ASP A 1 295 ? 0.95452   12.81160  -23.01525 1.000 48.32963 ? 295 ASP A OD1 1 
ATOM   2270 O  OD2 . ASP A 1 295 ? 1.10236   10.91550  -24.11350 1.000 37.20290 ? 295 ASP A OD2 1 
ATOM   2271 N  N   . VAL A 1 296 ? 6.05290   13.12321  -23.63712 1.000 45.86175 ? 296 VAL A N   1 
ATOM   2272 C  CA  . VAL A 1 296 ? 7.47419   12.98740  -23.32676 1.000 50.92449 ? 296 VAL A CA  1 
ATOM   2273 C  C   . VAL A 1 296 ? 7.97279   14.20973  -22.56682 1.000 56.91089 ? 296 VAL A C   1 
ATOM   2274 O  O   . VAL A 1 296 ? 8.61909   14.09045  -21.52061 1.000 59.56622 ? 296 VAL A O   1 
ATOM   2275 C  CB  . VAL A 1 296 ? 8.28494   12.75449  -24.61359 1.000 40.74640 ? 296 VAL A CB  1 
ATOM   2276 C  CG1 . VAL A 1 296 ? 9.77030   12.94679  -24.34684 1.000 45.59224 ? 296 VAL A CG1 1 
ATOM   2277 C  CG2 . VAL A 1 296 ? 8.01886   11.36277  -25.15759 1.000 38.38774 ? 296 VAL A CG2 1 
ATOM   2278 N  N   . VAL A 1 297 ? 7.67447   15.40570  -23.07863 1.000 57.29655 ? 297 VAL A N   1 
ATOM   2279 C  CA  . VAL A 1 297 ? 8.10304   16.62696  -22.40076 1.000 56.27443 ? 297 VAL A CA  1 
ATOM   2280 C  C   . VAL A 1 297 ? 7.44569   16.75207  -21.03234 1.000 61.20512 ? 297 VAL A C   1 
ATOM   2281 O  O   . VAL A 1 297 ? 7.99236   17.39665  -20.12807 1.000 70.88652 ? 297 VAL A O   1 
ATOM   2282 C  CB  . VAL A 1 297 ? 7.80893   17.85324  -23.28678 1.000 51.44443 ? 297 VAL A CB  1 
ATOM   2283 C  CG1 . VAL A 1 297 ? 8.41164   19.11085  -22.68780 1.000 61.31962 ? 297 VAL A CG1 1 
ATOM   2284 C  CG2 . VAL A 1 297 ? 8.34589   17.62808  -24.68571 1.000 48.55377 ? 297 VAL A CG2 1 
ATOM   2285 N  N   . ARG A 1 298 ? 6.28108   16.12658  -20.84813 1.000 62.30654 ? 298 ARG A N   1 
ATOM   2286 C  CA  . ARG A 1 298 ? 5.56906   16.21777  -19.57567 1.000 65.00946 ? 298 ARG A CA  1 
ATOM   2287 C  C   . ARG A 1 298 ? 6.26948   15.41323  -18.48530 1.000 64.26095 ? 298 ARG A C   1 
ATOM   2288 O  O   . ARG A 1 298 ? 6.74488   15.97337  -17.49151 1.000 73.77579 ? 298 ARG A O   1 
ATOM   2289 C  CB  . ARG A 1 298 ? 4.12375   15.74433  -19.74914 1.000 46.94736 ? 298 ARG A CB  1 
ATOM   2290 N  N   . GLN A 1 299 ? 6.33684   14.08984  -18.65100 1.000 64.48618 ? 299 GLN A N   1 
ATOM   2291 C  CA  . GLN A 1 299 ? 6.89878   13.24265  -17.60289 1.000 68.70813 ? 299 GLN A CA  1 
ATOM   2292 C  C   . GLN A 1 299 ? 8.41560   13.37000  -17.51102 1.000 71.15167 ? 299 GLN A C   1 
ATOM   2293 O  O   . GLN A 1 299 ? 8.98248   13.19039  -16.42726 1.000 81.43319 ? 299 GLN A O   1 
ATOM   2294 C  CB  . GLN A 1 299 ? 6.50028   11.78487  -17.83622 1.000 69.23836 ? 299 GLN A CB  1 
ATOM   2295 N  N   . CYS A 1 300 ? 9.08838   13.67340  -18.62161 1.000 74.47812 ? 300 CYS A N   1 
ATOM   2296 C  CA  . CYS A 1 300 ? 10.53782  13.84207  -18.60619 1.000 71.14283 ? 300 CYS A CA  1 
ATOM   2297 C  C   . CYS A 1 300 ? 10.91358  15.29720  -18.36577 1.000 78.22377 ? 300 CYS A C   1 
ATOM   2298 O  O   . CYS A 1 300 ? 10.84663  15.78366  -17.23200 1.000 75.93681 ? 300 CYS A O   1 
ATOM   2299 C  CB  . CYS A 1 300 ? 11.16580  13.35992  -19.91813 1.000 68.01366 ? 300 CYS A CB  1 
ATOM   2300 S  SG  . CYS A 1 300 ? 11.10800  11.57936  -20.18184 1.000 74.68870 ? 300 CYS A SG  1 
ATOM   2301 N  N   . SER A 1 301 ? 11.31233  15.98609  -19.43305 1.000 78.32923 ? 301 SER A N   1 
ATOM   2302 C  CA  . SER A 1 301 ? 11.75106  17.37826  -19.38180 1.000 74.07635 ? 301 SER A CA  1 
ATOM   2303 C  C   . SER A 1 301 ? 10.80186  18.28087  -18.59912 1.000 80.15921 ? 301 SER A C   1 
ATOM   2304 O  O   . SER A 1 301 ? 11.17637  18.84150  -17.56876 1.000 78.40279 ? 301 SER A O   1 
ATOM   2305 C  CB  . SER A 1 301 ? 11.91502  17.91842  -20.80327 1.000 74.91372 ? 301 SER A CB  1 
ATOM   2306 O  OG  . SER A 1 301 ? 12.16054  19.31369  -20.79909 1.000 80.17852 ? 301 SER A OG  1 
ATOM   2307 N  N   . SER B 1 1   ? -12.38309 -8.34083  -24.14759 1.000 38.41116 ? 1   SER B N   1 
ATOM   2308 C  CA  . SER B 1 1   ? -11.02338 -8.86597  -24.19719 1.000 43.81426 ? 1   SER B CA  1 
ATOM   2309 C  C   . SER B 1 1   ? -9.99919  -7.73588  -24.23180 1.000 42.10131 ? 1   SER B C   1 
ATOM   2310 O  O   . SER B 1 1   ? -10.35268 -6.55971  -24.13490 1.000 35.63031 ? 1   SER B O   1 
ATOM   2311 C  CB  . SER B 1 1   ? -10.84795 -9.78101  -25.40874 1.000 40.96531 ? 1   SER B CB  1 
ATOM   2312 O  OG  . SER B 1 1   ? -11.19907 -9.10998  -26.60308 1.000 44.68653 ? 1   SER B OG  1 
ATOM   2313 N  N   . GLY B 1 2   ? -8.73193  -8.10012  -24.38254 1.000 38.55456 ? 2   GLY B N   1 
ATOM   2314 C  CA  . GLY B 1 2   ? -7.63795  -7.16581  -24.24031 1.000 33.40533 ? 2   GLY B CA  1 
ATOM   2315 C  C   . GLY B 1 2   ? -7.03727  -7.20769  -22.84373 1.000 33.94698 ? 2   GLY B C   1 
ATOM   2316 O  O   . GLY B 1 2   ? -7.68555  -7.57928  -21.86249 1.000 35.68998 ? 2   GLY B O   1 
ATOM   2317 N  N   . PHE B 1 3   ? -5.76906  -6.81258  -22.75502 1.000 33.95337 ? 3   PHE B N   1 
ATOM   2318 C  CA  . PHE B 1 3   ? -5.05613  -6.86126  -21.48307 1.000 36.70675 ? 3   PHE B CA  1 
ATOM   2319 C  C   . PHE B 1 3   ? -4.08991  -5.69175  -21.41644 1.000 34.21871 ? 3   PHE B C   1 
ATOM   2320 O  O   . PHE B 1 3   ? -3.25920  -5.52078  -22.31249 1.000 37.21199 ? 3   PHE B O   1 
ATOM   2321 C  CB  . PHE B 1 3   ? -4.31284  -8.18758  -21.31857 1.000 38.31523 ? 3   PHE B CB  1 
ATOM   2322 C  CG  . PHE B 1 3   ? -4.10511  -8.58437  -19.88740 1.000 35.84933 ? 3   PHE B CG  1 
ATOM   2323 C  CD1 . PHE B 1 3   ? -5.15920  -9.08042  -19.13661 1.000 37.38056 ? 3   PHE B CD1 1 
ATOM   2324 C  CD2 . PHE B 1 3   ? -2.86454  -8.45269  -19.28804 1.000 35.95029 ? 3   PHE B CD2 1 
ATOM   2325 C  CE1 . PHE B 1 3   ? -4.97970  -9.44048  -17.81434 1.000 34.92344 ? 3   PHE B CE1 1 
ATOM   2326 C  CE2 . PHE B 1 3   ? -2.67711  -8.81342  -17.96467 1.000 37.83955 ? 3   PHE B CE2 1 
ATOM   2327 C  CZ  . PHE B 1 3   ? -3.73709  -9.30826  -17.22756 1.000 40.32434 ? 3   PHE B CZ  1 
ATOM   2328 N  N   . ARG B 1 4   ? -4.20421  -4.88756  -20.36282 1.000 34.78384 ? 4   ARG B N   1 
ATOM   2329 C  CA  . ARG B 1 4   ? -3.33921  -3.73437  -20.17391 1.000 33.74100 ? 4   ARG B CA  1 
ATOM   2330 C  C   . ARG B 1 4   ? -2.96165  -3.63003  -18.70503 1.000 34.52190 ? 4   ARG B C   1 
ATOM   2331 O  O   . ARG B 1 4   ? -3.64743  -4.15962  -17.82598 1.000 30.92471 ? 4   ARG B O   1 
ATOM   2332 C  CB  . ARG B 1 4   ? -4.00646  -2.43175  -20.64052 1.000 35.99396 ? 4   ARG B CB  1 
ATOM   2333 C  CG  . ARG B 1 4   ? -4.37619  -2.41301  -22.11379 1.000 41.13813 ? 4   ARG B CG  1 
ATOM   2334 C  CD  . ARG B 1 4   ? -4.54715  -0.99602  -22.62346 1.000 40.50567 ? 4   ARG B CD  1 
ATOM   2335 N  NE  . ARG B 1 4   ? -3.27230  -0.30247  -22.74880 1.000 39.60675 ? 4   ARG B NE  1 
ATOM   2336 C  CZ  . ARG B 1 4   ? -2.72172  0.05354   -23.90143 1.000 39.16756 ? 4   ARG B CZ  1 
ATOM   2337 N  NH1 . ARG B 1 4   ? -3.32571  -0.17339  -25.05638 1.000 26.19758 ? 4   ARG B NH1 1 
ATOM   2338 N  NH2 . ARG B 1 4   ? -1.53690  0.65727   -23.89441 1.000 37.53499 ? 4   ARG B NH2 1 
ATOM   2339 N  N   . LYS B 1 5   ? -1.85405  -2.93842  -18.44811 1.000 32.77375 ? 5   LYS B N   1 
ATOM   2340 C  CA  . LYS B 1 5   ? -1.39310  -2.71530  -17.08044 1.000 37.50883 ? 5   LYS B CA  1 
ATOM   2341 C  C   . LYS B 1 5   ? -2.32794  -1.70760  -16.42618 1.000 33.15317 ? 5   LYS B C   1 
ATOM   2342 O  O   . LYS B 1 5   ? -2.23642  -0.50146  -16.66415 1.000 44.11268 ? 5   LYS B O   1 
ATOM   2343 C  CB  . LYS B 1 5   ? 0.05492   -2.23893  -17.06972 1.000 29.15126 ? 5   LYS B CB  1 
ATOM   2344 C  CG  . LYS B 1 5   ? 0.72328   -2.35554  -15.71039 1.000 38.32597 ? 5   LYS B CG  1 
ATOM   2345 C  CD  . LYS B 1 5   ? 2.24255   -2.40691  -15.82767 1.000 49.55308 ? 5   LYS B CD  1 
ATOM   2346 C  CE  . LYS B 1 5   ? 2.71170   -3.72559  -16.42406 1.000 50.80276 ? 5   LYS B CE  1 
ATOM   2347 N  NZ  . LYS B 1 5   ? 4.19901   -3.83086  -16.44776 1.000 54.65459 ? 5   LYS B NZ  1 
ATOM   2348 N  N   . MET B 1 6   ? -3.23008  -2.20813  -15.59112 1.000 36.82172 ? 6   MET B N   1 
ATOM   2349 C  CA  . MET B 1 6   ? -4.37087  -1.45186  -15.09575 1.000 36.15030 ? 6   MET B CA  1 
ATOM   2350 C  C   . MET B 1 6   ? -4.14976  -1.05991  -13.64107 1.000 31.73743 ? 6   MET B C   1 
ATOM   2351 O  O   . MET B 1 6   ? -3.79511  -1.90413  -12.81270 1.000 28.70982 ? 6   MET B O   1 
ATOM   2352 C  CB  . MET B 1 6   ? -5.64596  -2.28401  -15.23781 1.000 25.97175 ? 6   MET B CB  1 
ATOM   2353 C  CG  . MET B 1 6   ? -6.93715  -1.53184  -15.01874 1.000 39.72219 ? 6   MET B CG  1 
ATOM   2354 S  SD  . MET B 1 6   ? -8.34906  -2.54999  -15.50194 1.000 48.23067 ? 6   MET B SD  1 
ATOM   2355 C  CE  . MET B 1 6   ? -7.94454  -2.89237  -17.20584 1.000 32.15010 ? 6   MET B CE  1 
ATOM   2356 N  N   . ALA B 1 7   ? -4.35945  0.21434   -13.33541 1.000 30.51870 ? 7   ALA B N   1 
ATOM   2357 C  CA  . ALA B 1 7   ? -4.28679  0.71176   -11.97140 1.000 31.36086 ? 7   ALA B CA  1 
ATOM   2358 C  C   . ALA B 1 7   ? -5.68600  0.83336   -11.38012 1.000 29.32855 ? 7   ALA B C   1 
ATOM   2359 O  O   . ALA B 1 7   ? -6.68551  0.89717   -12.09880 1.000 31.88775 ? 7   ALA B O   1 
ATOM   2360 C  CB  . ALA B 1 7   ? -3.57407  2.06672   -11.92381 1.000 29.25670 ? 7   ALA B CB  1 
ATOM   2361 N  N   . PHE B 1 8   ? -5.74593  0.85452   -10.05138 1.000 24.93470 ? 8   PHE B N   1 
ATOM   2362 C  CA  . PHE B 1 8   ? -7.00427  1.11644   -9.37885  1.000 27.79212 ? 8   PHE B CA  1 
ATOM   2363 C  C   . PHE B 1 8   ? -7.43785  2.55981   -9.62543  1.000 34.98690 ? 8   PHE B C   1 
ATOM   2364 O  O   . PHE B 1 8   ? -6.59927  3.44011   -9.83923  1.000 29.54257 ? 8   PHE B O   1 
ATOM   2365 C  CB  . PHE B 1 8   ? -6.88251  0.87190   -7.87584  1.000 28.43768 ? 8   PHE B CB  1 
ATOM   2366 C  CG  . PHE B 1 8   ? -6.90402  -0.57812  -7.48980  1.000 25.70705 ? 8   PHE B CG  1 
ATOM   2367 C  CD1 . PHE B 1 8   ? -8.09038  -1.29196  -7.49500  1.000 31.79693 ? 8   PHE B CD1 1 
ATOM   2368 C  CD2 . PHE B 1 8   ? -5.74022  -1.22411  -7.10835  1.000 28.42309 ? 8   PHE B CD2 1 
ATOM   2369 C  CE1 . PHE B 1 8   ? -8.11563  -2.62756  -7.13691  1.000 32.77912 ? 8   PHE B CE1 1 
ATOM   2370 C  CE2 . PHE B 1 8   ? -5.75858  -2.56025  -6.74812  1.000 29.31064 ? 8   PHE B CE2 1 
ATOM   2371 C  CZ  . PHE B 1 8   ? -6.94695  -3.26233  -6.76281  1.000 28.62728 ? 8   PHE B CZ  1 
ATOM   2372 N  N   . PRO B 1 9   ? -8.74240  2.82774   -9.61231  1.000 31.73025 ? 9   PRO B N   1 
ATOM   2373 C  CA  . PRO B 1 9   ? -9.19964  4.22335   -9.62411  1.000 32.74393 ? 9   PRO B CA  1 
ATOM   2374 C  C   . PRO B 1 9   ? -8.66649  4.94854   -8.39694  1.000 29.59780 ? 9   PRO B C   1 
ATOM   2375 O  O   . PRO B 1 9   ? -8.77103  4.45855   -7.27141  1.000 34.21772 ? 9   PRO B O   1 
ATOM   2376 C  CB  . PRO B 1 9   ? -10.72917 4.10134   -9.60541  1.000 30.14773 ? 9   PRO B CB  1 
ATOM   2377 C  CG  . PRO B 1 9   ? -11.01045 2.70929   -10.09973 1.000 33.03797 ? 9   PRO B CG  1 
ATOM   2378 C  CD  . PRO B 1 9   ? -9.86309  1.87318   -9.61634  1.000 28.50123 ? 9   PRO B CD  1 
ATOM   2379 N  N   . SER B 1 10  ? -8.07317  6.11646   -8.62305  1.000 29.99287 ? 10  SER B N   1 
ATOM   2380 C  CA  . SER B 1 10  ? -7.27346  6.78742   -7.60767  1.000 35.73061 ? 10  SER B CA  1 
ATOM   2381 C  C   . SER B 1 10  ? -8.03368  7.86780   -6.84733  1.000 33.32545 ? 10  SER B C   1 
ATOM   2382 O  O   . SER B 1 10  ? -7.42322  8.58856   -6.05137  1.000 37.03374 ? 10  SER B O   1 
ATOM   2383 C  CB  . SER B 1 10  ? -6.02681  7.39167   -8.25250  1.000 33.93402 ? 10  SER B CB  1 
ATOM   2384 O  OG  . SER B 1 10  ? -6.38848  8.33152   -9.24850  1.000 32.73125 ? 10  SER B OG  1 
ATOM   2385 N  N   . GLY B 1 11  ? -9.34742  7.98097   -7.05369  1.000 33.38258 ? 11  GLY B N   1 
ATOM   2386 C  CA  . GLY B 1 11  ? -10.08923 9.09461   -6.47891  1.000 33.84509 ? 11  GLY B CA  1 
ATOM   2387 C  C   . GLY B 1 11  ? -10.04334 9.13882   -4.96193  1.000 34.34717 ? 11  GLY B C   1 
ATOM   2388 O  O   . GLY B 1 11  ? -9.84828  10.20300  -4.36921  1.000 36.74305 ? 11  GLY B O   1 
ATOM   2389 N  N   . LYS B 1 12  ? -10.22539 7.98735   -4.31113  1.000 32.59349 ? 12  LYS B N   1 
ATOM   2390 C  CA  . LYS B 1 12  ? -10.22042 7.96203   -2.85064  1.000 26.22607 ? 12  LYS B CA  1 
ATOM   2391 C  C   . LYS B 1 12  ? -8.86968  8.37452   -2.27459  1.000 31.32581 ? 12  LYS B C   1 
ATOM   2392 O  O   . LYS B 1 12  ? -8.80196  8.85437   -1.13700  1.000 33.59034 ? 12  LYS B O   1 
ATOM   2393 C  CB  . LYS B 1 12  ? -10.61209 6.57286   -2.35171  1.000 32.33722 ? 12  LYS B CB  1 
ATOM   2394 C  CG  . LYS B 1 12  ? -12.07890 6.22374   -2.59139  1.000 29.52419 ? 12  LYS B CG  1 
ATOM   2395 C  CD  . LYS B 1 12  ? -12.39775 4.81252   -2.12422  1.000 38.55723 ? 12  LYS B CD  1 
ATOM   2396 C  CE  . LYS B 1 12  ? -13.89372 4.52299   -2.17950  1.000 45.07771 ? 12  LYS B CE  1 
ATOM   2397 N  NZ  . LYS B 1 12  ? -14.45391 4.69160   -3.55072  1.000 47.03406 ? 12  LYS B NZ  1 
ATOM   2398 N  N   . VAL B 1 13  ? -7.79360  8.20925   -3.03876  1.000 31.67643 ? 13  VAL B N   1 
ATOM   2399 C  CA  . VAL B 1 13  ? -6.46555  8.61198   -2.58591  1.000 33.32078 ? 13  VAL B CA  1 
ATOM   2400 C  C   . VAL B 1 13  ? -6.16716  10.06051  -2.95547  1.000 38.14546 ? 13  VAL B C   1 
ATOM   2401 O  O   . VAL B 1 13  ? -5.49042  10.76847  -2.20448  1.000 34.82138 ? 13  VAL B O   1 
ATOM   2402 C  CB  . VAL B 1 13  ? -5.40701  7.65066   -3.16322  1.000 27.42015 ? 13  VAL B CB  1 
ATOM   2403 C  CG1 . VAL B 1 13  ? -4.01463  8.03432   -2.69796  1.000 27.62015 ? 13  VAL B CG1 1 
ATOM   2404 C  CG2 . VAL B 1 13  ? -5.72494  6.21380   -2.76774  1.000 30.32695 ? 13  VAL B CG2 1 
ATOM   2405 N  N   . GLU B 1 14  ? -6.66659  10.52158  -4.10850  1.000 36.87892 ? 14  GLU B N   1 
ATOM   2406 C  CA  . GLU B 1 14  ? -6.44150  11.90600  -4.52199  1.000 36.20456 ? 14  GLU B CA  1 
ATOM   2407 C  C   . GLU B 1 14  ? -6.91551  12.89116  -3.45956  1.000 37.15355 ? 14  GLU B C   1 
ATOM   2408 O  O   . GLU B 1 14  ? -6.28454  13.93110  -3.23702  1.000 39.88880 ? 14  GLU B O   1 
ATOM   2409 C  CB  . GLU B 1 14  ? -7.15369  12.18435  -5.84752  1.000 32.49883 ? 14  GLU B CB  1 
ATOM   2410 C  CG  . GLU B 1 14  ? -6.61912  11.40831  -7.03485  1.000 34.21225 ? 14  GLU B CG  1 
ATOM   2411 C  CD  . GLU B 1 14  ? -7.53297  11.50367  -8.24272  1.000 38.05092 ? 14  GLU B CD  1 
ATOM   2412 O  OE1 . GLU B 1 14  ? -8.05669  12.60635  -8.51085  1.000 33.47210 ? 14  GLU B OE1 1 
ATOM   2413 O  OE2 . GLU B 1 14  ? -7.73733  10.47236  -8.91657  1.000 33.49147 ? 14  GLU B OE2 1 
ATOM   2414 N  N   . GLY B 1 15  ? -8.02385  12.57864  -2.78980  1.000 32.85147 ? 15  GLY B N   1 
ATOM   2415 C  CA  . GLY B 1 15  ? -8.56711  13.45082  -1.76765  1.000 40.50862 ? 15  GLY B CA  1 
ATOM   2416 C  C   . GLY B 1 15  ? -7.76387  13.52908  -0.48831  1.000 42.41246 ? 15  GLY B C   1 
ATOM   2417 O  O   . GLY B 1 15  ? -8.15385  14.26524  0.42222   1.000 43.35385 ? 15  GLY B O   1 
ATOM   2418 N  N   . CYS B 1 16  ? -6.65077  12.80418  -0.39251  1.000 37.07453 ? 16  CYS B N   1 
ATOM   2419 C  CA  . CYS B 1 16  ? -5.83707  12.77821  0.81370   1.000 35.91653 ? 16  CYS B CA  1 
ATOM   2420 C  C   . CYS B 1 16  ? -4.46504  13.40612  0.63028   1.000 36.48080 ? 16  CYS B C   1 
ATOM   2421 O  O   . CYS B 1 16  ? -3.71449  13.50810  1.60634   1.000 46.62844 ? 16  CYS B O   1 
ATOM   2422 C  CB  . CYS B 1 16  ? -5.66679  11.33644  1.30417   1.000 31.88678 ? 16  CYS B CB  1 
ATOM   2423 S  SG  . CYS B 1 16  ? -7.21007  10.45233  1.54313   1.000 40.95348 ? 16  CYS B SG  1 
ATOM   2424 N  N   . MET B 1 17  ? -4.11255  13.82337  -0.58215  1.000 36.64195 ? 17  MET B N   1 
ATOM   2425 C  CA  . MET B 1 17  ? -2.76655  14.29813  -0.87471  1.000 33.70420 ? 17  MET B CA  1 
ATOM   2426 C  C   . MET B 1 17  ? -2.65060  15.78195  -0.54533  1.000 43.24469 ? 17  MET B C   1 
ATOM   2427 O  O   . MET B 1 17  ? -3.42020  16.60114  -1.05968  1.000 35.95326 ? 17  MET B O   1 
ATOM   2428 C  CB  . MET B 1 17  ? -2.41462  14.04460  -2.33886  1.000 34.96845 ? 17  MET B CB  1 
ATOM   2429 C  CG  . MET B 1 17  ? -2.45131  12.57759  -2.73590  1.000 40.50721 ? 17  MET B CG  1 
ATOM   2430 S  SD  . MET B 1 17  ? -1.46678  11.53114  -1.64837  1.000 35.87635 ? 17  MET B SD  1 
ATOM   2431 C  CE  . MET B 1 17  ? 0.14316   12.31046  -1.77730  1.000 33.07996 ? 17  MET B CE  1 
ATOM   2432 N  N   . VAL B 1 18  ? -1.68195  16.12284  0.30323   1.000 38.97622 ? 18  VAL B N   1 
ATOM   2433 C  CA  . VAL B 1 18  ? -1.39207  17.50160  0.66706   1.000 42.34178 ? 18  VAL B CA  1 
ATOM   2434 C  C   . VAL B 1 18  ? 0.07973   17.78089  0.37762   1.000 47.06416 ? 18  VAL B C   1 
ATOM   2435 O  O   . VAL B 1 18  ? 0.86606   16.87603  0.09542   1.000 42.66719 ? 18  VAL B O   1 
ATOM   2436 C  CB  . VAL B 1 18  ? -1.72214  17.80176  2.14216   1.000 43.38754 ? 18  VAL B CB  1 
ATOM   2437 C  CG1 . VAL B 1 18  ? -3.20256  17.59541  2.41209   1.000 39.02600 ? 18  VAL B CG1 1 
ATOM   2438 C  CG2 . VAL B 1 18  ? -0.88227  16.92874  3.06041   1.000 46.60837 ? 18  VAL B CG2 1 
ATOM   2439 N  N   . GLN B 1 19  ? 0.44367   19.05744  0.45260   1.000 48.11283 ? 19  GLN B N   1 
ATOM   2440 C  CA  . GLN B 1 19  ? 1.82498   19.48734  0.29132   1.000 46.73913 ? 19  GLN B CA  1 
ATOM   2441 C  C   . GLN B 1 19  ? 2.42828   19.79169  1.65540   1.000 44.24152 ? 19  GLN B C   1 
ATOM   2442 O  O   . GLN B 1 19  ? 1.77260   20.38469  2.51698   1.000 44.62598 ? 19  GLN B O   1 
ATOM   2443 C  CB  . GLN B 1 19  ? 1.91982   20.72237  -0.60642  1.000 51.32529 ? 19  GLN B CB  1 
ATOM   2444 C  CG  . GLN B 1 19  ? 3.34758   21.16195  -0.90514  1.000 52.07096 ? 19  GLN B CG  1 
ATOM   2445 C  CD  . GLN B 1 19  ? 3.41578   22.54764  -1.51707  1.000 59.97474 ? 19  GLN B CD  1 
ATOM   2446 O  OE1 . GLN B 1 19  ? 4.24246   22.81550  -2.39010  1.000 65.31383 ? 19  GLN B OE1 1 
ATOM   2447 N  NE2 . GLN B 1 19  ? 2.54788   23.43951  -1.05586  1.000 49.08847 ? 19  GLN B NE2 1 
ATOM   2448 N  N   . VAL B 1 20  ? 3.68006   19.38086  1.84627   1.000 45.16505 ? 20  VAL B N   1 
ATOM   2449 C  CA  . VAL B 1 20  ? 4.39434   19.57129  3.10339   1.000 42.65522 ? 20  VAL B CA  1 
ATOM   2450 C  C   . VAL B 1 20  ? 5.71398   20.26550  2.79993   1.000 47.83026 ? 20  VAL B C   1 
ATOM   2451 O  O   . VAL B 1 20  ? 6.52052   19.75701  2.01137   1.000 48.43583 ? 20  VAL B O   1 
ATOM   2452 C  CB  . VAL B 1 20  ? 4.63945   18.24153  3.83703   1.000 40.85932 ? 20  VAL B CB  1 
ATOM   2453 C  CG1 . VAL B 1 20  ? 5.51483   18.46276  5.06291   1.000 43.06757 ? 20  VAL B CG1 1 
ATOM   2454 C  CG2 . VAL B 1 20  ? 3.31923   17.60278  4.23435   1.000 35.84441 ? 20  VAL B CG2 1 
ATOM   2455 N  N   . ILE B 1 21  ? 5.93471   21.42063  3.42200   1.000 54.39673 ? 21  ILE B N   1 
ATOM   2456 C  CA  . ILE B 1 21  ? 7.17631   22.16856  3.27942   1.000 54.77524 ? 21  ILE B CA  1 
ATOM   2457 C  C   . ILE B 1 21  ? 7.85526   22.24523  4.63835   1.000 54.99034 ? 21  ILE B C   1 
ATOM   2458 O  O   . ILE B 1 21  ? 7.20386   22.50487  5.65578   1.000 54.89539 ? 21  ILE B O   1 
ATOM   2459 C  CB  . ILE B 1 21  ? 6.93715   23.58521  2.71884   1.000 61.21510 ? 21  ILE B CB  1 
ATOM   2460 C  CG1 . ILE B 1 21  ? 6.06215   23.53188  1.46546   1.000 55.61629 ? 21  ILE B CG1 1 
ATOM   2461 C  CG2 . ILE B 1 21  ? 8.26472   24.26088  2.41225   1.000 55.37446 ? 21  ILE B CG2 1 
ATOM   2462 C  CD1 . ILE B 1 21  ? 5.72592   24.89737  0.90668   1.000 56.99567 ? 21  ILE B CD1 1 
ATOM   2463 N  N   . CYS B 1 22  ? 9.16529   22.00977  4.65167   1.000 55.95148 ? 22  CYS B N   1 
ATOM   2464 C  CA  . CYS B 1 22  ? 9.99008   22.21194  5.84286   1.000 61.24481 ? 22  CYS B CA  1 
ATOM   2465 C  C   . CYS B 1 22  ? 11.24518  22.94435  5.38185   1.000 61.51256 ? 22  CYS B C   1 
ATOM   2466 O  O   . CYS B 1 22  ? 12.13861  22.33755  4.78417   1.000 56.07570 ? 22  CYS B O   1 
ATOM   2467 C  CB  . CYS B 1 22  ? 10.32661  20.89285  6.52954   1.000 67.28255 ? 22  CYS B CB  1 
ATOM   2468 S  SG  . CYS B 1 22  ? 11.12155  21.07823  8.14500   1.000 66.16588 ? 22  CYS B SG  1 
ATOM   2469 N  N   . GLY B 1 23  ? 11.30261  24.24506  5.65283   1.000 66.57489 ? 23  GLY B N   1 
ATOM   2470 C  CA  . GLY B 1 23  ? 12.38697  25.06336  5.15380   1.000 59.56339 ? 23  GLY B CA  1 
ATOM   2471 C  C   . GLY B 1 23  ? 12.33912  25.19557  3.64664   1.000 63.70147 ? 23  GLY B C   1 
ATOM   2472 O  O   . GLY B 1 23  ? 11.40359  25.78637  3.09914   1.000 68.90529 ? 23  GLY B O   1 
ATOM   2473 N  N   . THR B 1 24  ? 13.33950  24.64163  2.96224   1.000 61.23815 ? 24  THR B N   1 
ATOM   2474 C  CA  . THR B 1 24  ? 13.37095  24.65359  1.50683   1.000 65.82963 ? 24  THR B CA  1 
ATOM   2475 C  C   . THR B 1 24  ? 12.89090  23.35090  0.88368   1.000 66.81743 ? 24  THR B C   1 
ATOM   2476 O  O   . THR B 1 24  ? 12.59540  23.32986  -0.31595  1.000 65.51806 ? 24  THR B O   1 
ATOM   2477 C  CB  . THR B 1 24  ? 14.78913  24.95202  1.00528   1.000 72.08768 ? 24  THR B CB  1 
ATOM   2478 O  OG1 . THR B 1 24  ? 15.72866  24.11267  1.68930   1.000 73.10801 ? 24  THR B OG1 1 
ATOM   2479 C  CG2 . THR B 1 24  ? 15.14336  26.41297  1.24223   1.000 71.63814 ? 24  THR B CG2 1 
ATOM   2480 N  N   . THR B 1 25  ? 12.80480  22.27475  1.66071   1.000 72.33266 ? 25  THR B N   1 
ATOM   2481 C  CA  . THR B 1 25  ? 12.34150  21.00126  1.12840   1.000 64.80745 ? 25  THR B CA  1 
ATOM   2482 C  C   . THR B 1 25  ? 10.83067  21.03162  0.93602   1.000 57.38479 ? 25  THR B C   1 
ATOM   2483 O  O   . THR B 1 25  ? 10.09008  21.48996  1.81130   1.000 61.82988 ? 25  THR B O   1 
ATOM   2484 C  CB  . THR B 1 25  ? 12.73400  19.85876  2.06529   1.000 64.89395 ? 25  THR B CB  1 
ATOM   2485 O  OG1 . THR B 1 25  ? 14.15928  19.82786  2.21504   1.000 71.10228 ? 25  THR B OG1 1 
ATOM   2486 C  CG2 . THR B 1 25  ? 12.26111  18.52112  1.50898   1.000 57.73967 ? 25  THR B CG2 1 
ATOM   2487 N  N   . THR B 1 26  ? 10.37552  20.54708  -0.21616  1.000 56.00047 ? 26  THR B N   1 
ATOM   2488 C  CA  . THR B 1 26  ? 8.95653   20.46279  -0.52946  1.000 53.72440 ? 26  THR B CA  1 
ATOM   2489 C  C   . THR B 1 26  ? 8.65281   19.07165  -1.06237  1.000 51.58491 ? 26  THR B C   1 
ATOM   2490 O  O   . THR B 1 26  ? 9.29058   18.61948  -2.01872  1.000 59.38397 ? 26  THR B O   1 
ATOM   2491 C  CB  . THR B 1 26  ? 8.55043   21.52302  -1.55791  1.000 60.75000 ? 26  THR B CB  1 
ATOM   2492 O  OG1 . THR B 1 26  ? 8.92310   22.82261  -1.08129  1.000 66.50192 ? 26  THR B OG1 1 
ATOM   2493 C  CG2 . THR B 1 26  ? 7.05006   21.48308  -1.79640  1.000 58.09276 ? 26  THR B CG2 1 
ATOM   2494 N  N   . LEU B 1 27  ? 7.68827   18.39596  -0.44403  1.000 51.34175 ? 27  LEU B N   1 
ATOM   2495 C  CA  . LEU B 1 27  ? 7.29151   17.05977  -0.87122  1.000 47.65471 ? 27  LEU B CA  1 
ATOM   2496 C  C   . LEU B 1 27  ? 5.82002   16.85367  -0.52152  1.000 47.22225 ? 27  LEU B C   1 
ATOM   2497 O  O   . LEU B 1 27  ? 5.10833   17.79871  -0.16744  1.000 44.92623 ? 27  LEU B O   1 
ATOM   2498 C  CB  . LEU B 1 27  ? 8.21262   15.99766  -0.25392  1.000 45.21093 ? 27  LEU B CB  1 
ATOM   2499 C  CG  . LEU B 1 27  ? 8.67379   16.14790  1.19859   1.000 44.77380 ? 27  LEU B CG  1 
ATOM   2500 C  CD1 . LEU B 1 27  ? 7.55391   15.85525  2.18772   1.000 39.18580 ? 27  LEU B CD1 1 
ATOM   2501 C  CD2 . LEU B 1 27  ? 9.87069   15.24785  1.46215   1.000 46.65922 ? 27  LEU B CD2 1 
ATOM   2502 N  N   . ASN B 1 28  ? 5.36343   15.60886  -0.61973  1.000 43.71355 ? 28  ASN B N   1 
ATOM   2503 C  CA  . ASN B 1 28  ? 3.94838   15.28291  -0.53919  1.000 41.02246 ? 28  ASN B CA  1 
ATOM   2504 C  C   . ASN B 1 28  ? 3.62489   14.58140  0.77307   1.000 44.00074 ? 28  ASN B C   1 
ATOM   2505 O  O   . ASN B 1 28  ? 4.47137   13.90044  1.36010   1.000 44.22254 ? 28  ASN B O   1 
ATOM   2506 C  CB  . ASN B 1 28  ? 3.52830   14.39717  -1.71541  1.000 43.44301 ? 28  ASN B CB  1 
ATOM   2507 C  CG  . ASN B 1 28  ? 3.89844   14.99873  -3.05551  1.000 40.78233 ? 28  ASN B CG  1 
ATOM   2508 O  OD1 . ASN B 1 28  ? 3.20329   15.87361  -3.56758  1.000 39.98059 ? 28  ASN B OD1 1 
ATOM   2509 N  ND2 . ASN B 1 28  ? 5.00003   14.53107  -3.63116  1.000 38.17647 ? 28  ASN B ND2 1 
ATOM   2510 N  N   . GLY B 1 29  ? 2.38065   14.75426  1.22445   1.000 31.17417 ? 29  GLY B N   1 
ATOM   2511 C  CA  . GLY B 1 29  ? 1.92769   14.13704  2.44737   1.000 36.83882 ? 29  GLY B CA  1 
ATOM   2512 C  C   . GLY B 1 29  ? 0.57941   13.46876  2.25918   1.000 36.97522 ? 29  GLY B C   1 
ATOM   2513 O  O   . GLY B 1 29  ? -0.18335  13.79418  1.34938   1.000 42.85966 ? 29  GLY B O   1 
ATOM   2514 N  N   . LEU B 1 30  ? 0.29894   12.51823  3.14775   1.000 33.70791 ? 30  LEU B N   1 
ATOM   2515 C  CA  . LEU B 1 30  ? -0.94947  11.76202  3.14123   1.000 36.42779 ? 30  LEU B CA  1 
ATOM   2516 C  C   . LEU B 1 30  ? -1.78770  12.21858  4.32973   1.000 43.87114 ? 30  LEU B C   1 
ATOM   2517 O  O   . LEU B 1 30  ? -1.41158  11.99361  5.48497   1.000 41.09739 ? 30  LEU B O   1 
ATOM   2518 C  CB  . LEU B 1 30  ? -0.67878  10.26017  3.20022   1.000 34.85913 ? 30  LEU B CB  1 
ATOM   2519 C  CG  . LEU B 1 30  ? -1.88769  9.33527   3.03317   1.000 34.85366 ? 30  LEU B CG  1 
ATOM   2520 C  CD1 . LEU B 1 30  ? -2.50067  9.48359   1.64611   1.000 30.09581 ? 30  LEU B CD1 1 
ATOM   2521 C  CD2 . LEU B 1 30  ? -1.49590  7.89193   3.29161   1.000 33.23257 ? 30  LEU B CD2 1 
ATOM   2522 N  N   . TRP B 1 31  ? -2.92426  12.84948  4.04548   1.000 41.70149 ? 31  TRP B N   1 
ATOM   2523 C  CA  . TRP B 1 31  ? -3.77789  13.45169  5.06871   1.000 37.54866 ? 31  TRP B CA  1 
ATOM   2524 C  C   . TRP B 1 31  ? -4.93253  12.49834  5.36018   1.000 39.23324 ? 31  TRP B C   1 
ATOM   2525 O  O   . TRP B 1 31  ? -5.87719  12.39023  4.57532   1.000 38.59473 ? 31  TRP B O   1 
ATOM   2526 C  CB  . TRP B 1 31  ? -4.27681  14.81495  4.60196   1.000 39.03768 ? 31  TRP B CB  1 
ATOM   2527 C  CG  . TRP B 1 31  ? -5.09957  15.55778  5.60583   1.000 47.34013 ? 31  TRP B CG  1 
ATOM   2528 C  CD1 . TRP B 1 31  ? -5.12159  15.36662  6.95687   1.000 49.80020 ? 31  TRP B CD1 1 
ATOM   2529 C  CD2 . TRP B 1 31  ? -6.02857  16.61376  5.33426   1.000 50.00896 ? 31  TRP B CD2 1 
ATOM   2530 N  NE1 . TRP B 1 31  ? -6.00534  16.24085  7.54334   1.000 46.37054 ? 31  TRP B NE1 1 
ATOM   2531 C  CE2 . TRP B 1 31  ? -6.57448  17.01749  6.56798   1.000 48.87068 ? 31  TRP B CE2 1 
ATOM   2532 C  CE3 . TRP B 1 31  ? -6.45082  17.25704  4.16658   1.000 48.15411 ? 31  TRP B CE3 1 
ATOM   2533 C  CZ2 . TRP B 1 31  ? -7.52103  18.03559  6.66797   1.000 53.09635 ? 31  TRP B CZ2 1 
ATOM   2534 C  CZ3 . TRP B 1 31  ? -7.39048  18.26753  4.26796   1.000 53.71158 ? 31  TRP B CZ3 1 
ATOM   2535 C  CH2 . TRP B 1 31  ? -7.91610  18.64601  5.51073   1.000 53.29977 ? 31  TRP B CH2 1 
ATOM   2536 N  N   . LEU B 1 32  ? -4.85182  11.80541  6.49314   1.000 40.99890 ? 32  LEU B N   1 
ATOM   2537 C  CA  . LEU B 1 32  ? -5.88325  10.87385  6.92894   1.000 41.96942 ? 32  LEU B CA  1 
ATOM   2538 C  C   . LEU B 1 32  ? -6.33230  11.27170  8.32443   1.000 41.33629 ? 32  LEU B C   1 
ATOM   2539 O  O   . LEU B 1 32  ? -5.50194  11.39296  9.23175   1.000 43.91475 ? 32  LEU B O   1 
ATOM   2540 C  CB  . LEU B 1 32  ? -5.36969  9.43157   6.93038   1.000 41.36344 ? 32  LEU B CB  1 
ATOM   2541 C  CG  . LEU B 1 32  ? -4.86371  8.89479   5.59323   1.000 41.17453 ? 32  LEU B CG  1 
ATOM   2542 C  CD1 . LEU B 1 32  ? -4.16285  7.56039   5.79253   1.000 28.75797 ? 32  LEU B CD1 1 
ATOM   2543 C  CD2 . LEU B 1 32  ? -6.01752  8.76524   4.61155   1.000 32.93215 ? 32  LEU B CD2 1 
ATOM   2544 N  N   . ASP B 1 33  ? -7.64325  11.45703  8.49358   1.000 49.18596 ? 33  ASP B N   1 
ATOM   2545 C  CA  . ASP B 1 33  ? -8.19193  12.02158  9.72026   1.000 40.97409 ? 33  ASP B CA  1 
ATOM   2546 C  C   . ASP B 1 33  ? -7.47237  13.33125  10.02277  1.000 49.16829 ? 33  ASP B C   1 
ATOM   2547 O  O   . ASP B 1 33  ? -7.41254  14.21697  9.16325   1.000 46.66330 ? 33  ASP B O   1 
ATOM   2548 C  CB  . ASP B 1 33  ? -8.07328  11.02611  10.87706  1.000 44.07407 ? 33  ASP B CB  1 
ATOM   2549 C  CG  . ASP B 1 33  ? -8.77571  9.70925   10.58585  1.000 47.39628 ? 33  ASP B CG  1 
ATOM   2550 O  OD1 . ASP B 1 33  ? -9.98353  9.73378   10.27325  1.000 46.08748 ? 33  ASP B OD1 1 
ATOM   2551 O  OD2 . ASP B 1 33  ? -8.11487  8.64893   10.65437  1.000 51.24685 ? 33  ASP B OD2 1 
ATOM   2552 N  N   . ASP B 1 34  ? -6.88933  13.45822  11.21503  1.000 50.86278 ? 34  ASP B N   1 
ATOM   2553 C  CA  . ASP B 1 34  ? -6.20119  14.68157  11.61155  1.000 47.12817 ? 34  ASP B CA  1 
ATOM   2554 C  C   . ASP B 1 34  ? -4.68209  14.51583  11.64447  1.000 54.00742 ? 34  ASP B C   1 
ATOM   2555 O  O   . ASP B 1 34  ? -3.99657  15.19830  12.41020  1.000 54.70541 ? 34  ASP B O   1 
ATOM   2556 C  CB  . ASP B 1 34  ? -6.71779  15.17138  12.96569  1.000 52.86924 ? 34  ASP B CB  1 
ATOM   2557 C  CG  . ASP B 1 34  ? -6.64108  14.10758  14.05195  1.000 61.76082 ? 34  ASP B CG  1 
ATOM   2558 O  OD1 . ASP B 1 34  ? -5.90208  13.11526  13.88392  1.000 64.19486 ? 34  ASP B OD1 1 
ATOM   2559 O  OD2 . ASP B 1 34  ? -7.33103  14.26565  15.08176  1.000 65.92578 ? 34  ASP B OD2 1 
ATOM   2560 N  N   . VAL B 1 35  ? -4.13862  13.62387  10.81754  1.000 43.84108 ? 35  VAL B N   1 
ATOM   2561 C  CA  . VAL B 1 35  ? -2.70206  13.37657  10.76630  1.000 41.48833 ? 35  VAL B CA  1 
ATOM   2562 C  C   . VAL B 1 35  ? -2.24327  13.40014  9.31493   1.000 43.56487 ? 35  VAL B C   1 
ATOM   2563 O  O   . VAL B 1 35  ? -2.90526  12.83964  8.43387   1.000 38.10642 ? 35  VAL B O   1 
ATOM   2564 C  CB  . VAL B 1 35  ? -2.32704  12.03475  11.43155  1.000 38.52904 ? 35  VAL B CB  1 
ATOM   2565 C  CG1 . VAL B 1 35  ? -0.84467  11.74009  11.24300  1.000 39.20265 ? 35  VAL B CG1 1 
ATOM   2566 C  CG2 . VAL B 1 35  ? -2.67205  12.06333  12.90837  1.000 45.36994 ? 35  VAL B CG2 1 
ATOM   2567 N  N   . VAL B 1 36  ? -1.11245  14.05913  9.06917   1.000 35.65538 ? 36  VAL B N   1 
ATOM   2568 C  CA  . VAL B 1 36  ? -0.46073  14.08013  7.76502   1.000 37.46703 ? 36  VAL B CA  1 
ATOM   2569 C  C   . VAL B 1 36  ? 0.81085   13.24983  7.85989   1.000 41.34878 ? 36  VAL B C   1 
ATOM   2570 O  O   . VAL B 1 36  ? 1.65569   13.49581  8.72933   1.000 43.20759 ? 36  VAL B O   1 
ATOM   2571 C  CB  . VAL B 1 36  ? -0.14667  15.51566  7.30958   1.000 39.60191 ? 36  VAL B CB  1 
ATOM   2572 C  CG1 . VAL B 1 36  ? 0.74762   15.49760  6.07852   1.000 40.75606 ? 36  VAL B CG1 1 
ATOM   2573 C  CG2 . VAL B 1 36  ? -1.43353  16.28028  7.03054   1.000 39.45441 ? 36  VAL B CG2 1 
ATOM   2574 N  N   . TYR B 1 37  ? 0.94427   12.26952  6.97095   1.000 37.31539 ? 37  TYR B N   1 
ATOM   2575 C  CA  . TYR B 1 37  ? 2.10134   11.38604  6.93529   1.000 38.38884 ? 37  TYR B CA  1 
ATOM   2576 C  C   . TYR B 1 37  ? 3.01907   11.77708  5.78561   1.000 38.69881 ? 37  TYR B C   1 
ATOM   2577 O  O   . TYR B 1 37  ? 2.55157   12.12437  4.69857   1.000 40.86239 ? 37  TYR B O   1 
ATOM   2578 C  CB  . TYR B 1 37  ? 1.67313   9.92532   6.77457   1.000 36.83834 ? 37  TYR B CB  1 
ATOM   2579 C  CG  . TYR B 1 37  ? 0.71156   9.43301   7.83248   1.000 32.93982 ? 37  TYR B CG  1 
ATOM   2580 C  CD1 . TYR B 1 37  ? -0.64443  9.72719   7.75864   1.000 36.97942 ? 37  TYR B CD1 1 
ATOM   2581 C  CD2 . TYR B 1 37  ? 1.15558   8.66003   8.89802   1.000 36.58709 ? 37  TYR B CD2 1 
ATOM   2582 C  CE1 . TYR B 1 37  ? -1.53232  9.27544   8.72587   1.000 38.93912 ? 37  TYR B CE1 1 
ATOM   2583 C  CE2 . TYR B 1 37  ? 0.27453   8.19995   9.86861   1.000 30.08173 ? 37  TYR B CE2 1 
ATOM   2584 C  CZ  . TYR B 1 37  ? -1.06722  8.51197   9.77728   1.000 36.05455 ? 37  TYR B CZ  1 
ATOM   2585 O  OH  . TYR B 1 37  ? -1.94569  8.05869   10.73809  1.000 38.44165 ? 37  TYR B OH  1 
ATOM   2586 N  N   . CYS B 1 38  ? 4.32454   11.70146  6.02644   1.000 32.93523 ? 38  CYS B N   1 
ATOM   2587 C  CA  . CYS B 1 38  ? 5.32483   12.04934  5.02744   1.000 34.74847 ? 38  CYS B CA  1 
ATOM   2588 C  C   . CYS B 1 38  ? 6.65706   11.45175  5.46025   1.000 34.98962 ? 38  CYS B C   1 
ATOM   2589 O  O   . CYS B 1 38  ? 6.81473   11.06373  6.62471   1.000 33.91277 ? 38  CYS B O   1 
ATOM   2590 C  CB  . CYS B 1 38  ? 5.43823   13.57514  4.86005   1.000 36.76980 ? 38  CYS B CB  1 
ATOM   2591 S  SG  . CYS B 1 38  ? 6.29837   14.43407  6.19957   1.000 46.52550 ? 38  CYS B SG  1 
ATOM   2592 N  N   . PRO B 1 39  ? 7.62685   11.34631  4.54881   1.000 32.75301 ? 39  PRO B N   1 
ATOM   2593 C  CA  . PRO B 1 39  ? 8.94346   10.82784  4.94275   1.000 36.37352 ? 39  PRO B CA  1 
ATOM   2594 C  C   . PRO B 1 39  ? 9.59868   11.72194  5.98653   1.000 41.50197 ? 39  PRO B C   1 
ATOM   2595 O  O   . PRO B 1 39  ? 9.44594   12.94597  5.96896   1.000 39.47596 ? 39  PRO B O   1 
ATOM   2596 C  CB  . PRO B 1 39  ? 9.73425   10.82852  3.62943   1.000 39.81954 ? 39  PRO B CB  1 
ATOM   2597 C  CG  . PRO B 1 39  ? 8.70010   10.78955  2.56040   1.000 30.44374 ? 39  PRO B CG  1 
ATOM   2598 C  CD  . PRO B 1 39  ? 7.54057   11.57057  3.09450   1.000 39.53064 ? 39  PRO B CD  1 
ATOM   2599 N  N   . ARG B 1 40  ? 10.33600  11.09533  6.90782   1.000 33.91153 ? 40  ARG B N   1 
ATOM   2600 C  CA  . ARG B 1 40  ? 10.98047  11.85971  7.96848   1.000 35.79199 ? 40  ARG B CA  1 
ATOM   2601 C  C   . ARG B 1 40  ? 12.13765  12.70525  7.45135   1.000 47.88462 ? 40  ARG B C   1 
ATOM   2602 O  O   . ARG B 1 40  ? 12.49879  13.69430  8.09817   1.000 45.32871 ? 40  ARG B O   1 
ATOM   2603 C  CB  . ARG B 1 40  ? 11.46773  10.92722  9.08267   1.000 38.44502 ? 40  ARG B CB  1 
ATOM   2604 C  CG  . ARG B 1 40  ? 12.63780  10.02848  8.70516   1.000 39.81627 ? 40  ARG B CG  1 
ATOM   2605 C  CD  . ARG B 1 40  ? 13.17383  9.27857   9.92078   1.000 34.69736 ? 40  ARG B CD  1 
ATOM   2606 N  NE  . ARG B 1 40  ? 14.21851  8.32120   9.57284   1.000 34.92735 ? 40  ARG B NE  1 
ATOM   2607 C  CZ  . ARG B 1 40  ? 14.84799  7.54828   10.44891  1.000 39.83166 ? 40  ARG B CZ  1 
ATOM   2608 N  NH1 . ARG B 1 40  ? 14.56229  7.59205   11.73982  1.000 42.25361 ? 40  ARG B NH1 1 
ATOM   2609 N  NH2 . ARG B 1 40  ? 15.79550  6.71784   10.02095  1.000 37.80486 ? 40  ARG B NH2 1 
ATOM   2610 N  N   . HIS B 1 41  ? 12.71127  12.36045  6.29354   1.000 39.32839 ? 41  HIS B N   1 
ATOM   2611 C  CA  . HIS B 1 41  ? 13.85823  13.10464  5.78305   1.000 42.12079 ? 41  HIS B CA  1 
ATOM   2612 C  C   . HIS B 1 41  ? 13.49395  14.50345  5.30164   1.000 43.48676 ? 41  HIS B C   1 
ATOM   2613 O  O   . HIS B 1 41  ? 14.37952  15.22009  4.82523   1.000 49.32375 ? 41  HIS B O   1 
ATOM   2614 C  CB  . HIS B 1 41  ? 14.54830  12.32231  4.65668   1.000 44.50075 ? 41  HIS B CB  1 
ATOM   2615 C  CG  . HIS B 1 41  ? 13.78057  12.28896  3.36968   1.000 48.05498 ? 41  HIS B CG  1 
ATOM   2616 N  ND1 . HIS B 1 41  ? 13.18819  11.14201  2.88608   1.000 44.31042 ? 41  HIS B ND1 1 
ATOM   2617 C  CD2 . HIS B 1 41  ? 13.52531  13.25653  2.45643   1.000 44.67740 ? 41  HIS B CD2 1 
ATOM   2618 C  CE1 . HIS B 1 41  ? 12.59177  11.40712  1.73745   1.000 42.97762 ? 41  HIS B CE1 1 
ATOM   2619 N  NE2 . HIS B 1 41  ? 12.77964  12.68361  1.45536   1.000 49.76236 ? 41  HIS B NE2 1 
ATOM   2620 N  N   . VAL B 1 42  ? 12.22738  14.91139  5.41316   1.000 41.65958 ? 42  VAL B N   1 
ATOM   2621 C  CA  . VAL B 1 42  ? 11.83826  16.26078  5.02724   1.000 45.75933 ? 42  VAL B CA  1 
ATOM   2622 C  C   . VAL B 1 42  ? 12.49678  17.30558  5.91882   1.000 56.28948 ? 42  VAL B C   1 
ATOM   2623 O  O   . VAL B 1 42  ? 12.67329  18.45411  5.49883   1.000 60.08195 ? 42  VAL B O   1 
ATOM   2624 C  CB  . VAL B 1 42  ? 10.29994  16.39846  5.04983   1.000 44.49997 ? 42  VAL B CB  1 
ATOM   2625 C  CG1 . VAL B 1 42  ? 9.76961   16.32855  6.47681   1.000 44.27329 ? 42  VAL B CG1 1 
ATOM   2626 C  CG2 . VAL B 1 42  ? 9.85812   17.68827  4.36158   1.000 53.20806 ? 42  VAL B CG2 1 
ATOM   2627 N  N   . ILE B 1 43  ? 12.88961  16.92924  7.14222   1.000 56.42931 ? 43  ILE B N   1 
ATOM   2628 C  CA  . ILE B 1 43  ? 13.50917  17.87290  8.07193   1.000 64.81186 ? 43  ILE B CA  1 
ATOM   2629 C  C   . ILE B 1 43  ? 14.99884  18.04766  7.83671   1.000 61.42547 ? 43  ILE B C   1 
ATOM   2630 O  O   . ILE B 1 43  ? 15.62528  18.88131  8.50375   1.000 68.19189 ? 43  ILE B O   1 
ATOM   2631 C  CB  . ILE B 1 43  ? 13.29205  17.42984  9.53333   1.000 45.84435 ? 43  ILE B CB  1 
ATOM   2632 C  CG1 . ILE B 1 43  ? 14.04909  16.12929  9.81407   1.000 49.87898 ? 43  ILE B CG1 1 
ATOM   2633 C  CG2 . ILE B 1 43  ? 11.81056  17.25621  9.82294   1.000 51.47251 ? 43  ILE B CG2 1 
ATOM   2634 C  CD1 . ILE B 1 43  ? 13.84314  15.58879  11.21231  1.000 50.21294 ? 43  ILE B CD1 1 
ATOM   2635 N  N   . CYS B 1 44  ? 15.58646  17.29775  6.90993   1.000 56.42323 ? 44  CYS B N   1 
ATOM   2636 C  CA  . CYS B 1 44  ? 17.02868  17.30184  6.72017   1.000 58.30107 ? 44  CYS B CA  1 
ATOM   2637 C  C   . CYS B 1 44  ? 17.44108  18.28085  5.63073   1.000 71.25821 ? 44  CYS B C   1 
ATOM   2638 O  O   . CYS B 1 44  ? 16.77038  18.40829  4.60191   1.000 68.48696 ? 44  CYS B O   1 
ATOM   2639 C  CB  . CYS B 1 44  ? 17.52759  15.90331  6.35746   1.000 53.66998 ? 44  CYS B CB  1 
ATOM   2640 S  SG  . CYS B 1 44  ? 17.21754  14.63854  7.60159   1.000 62.46077 ? 44  CYS B SG  1 
ATOM   2641 N  N   . THR B 1 45  ? 18.55348  18.97095  5.86846   1.000 71.78785 ? 45  THR B N   1 
ATOM   2642 C  CA  . THR B 1 45  ? 19.23173  19.71414  4.82127   1.000 71.86668 ? 45  THR B CA  1 
ATOM   2643 C  C   . THR B 1 45  ? 20.11822  18.75838  4.02506   1.000 72.14019 ? 45  THR B C   1 
ATOM   2644 O  O   . THR B 1 45  ? 20.20416  17.56210  4.31721   1.000 71.81783 ? 45  THR B O   1 
ATOM   2645 C  CB  . THR B 1 45  ? 20.04832  20.85889  5.41852   1.000 74.18349 ? 45  THR B CB  1 
ATOM   2646 O  OG1 . THR B 1 45  ? 21.16990  20.32639  6.13443   1.000 68.11760 ? 45  THR B OG1 1 
ATOM   2647 C  CG2 . THR B 1 45  ? 19.19297  21.68449  6.37267   1.000 62.75848 ? 45  THR B CG2 1 
ATOM   2648 N  N   . SER B 1 46  ? 20.79194  19.28550  3.00047   1.000 76.61953 ? 46  SER B N   1 
ATOM   2649 C  CA  . SER B 1 46  ? 21.68026  18.43940  2.21022   1.000 74.00364 ? 46  SER B CA  1 
ATOM   2650 C  C   . SER B 1 46  ? 22.86678  17.95549  3.03429   1.000 73.50676 ? 46  SER B C   1 
ATOM   2651 O  O   . SER B 1 46  ? 23.34859  16.83490  2.82860   1.000 72.63717 ? 46  SER B O   1 
ATOM   2652 C  CB  . SER B 1 46  ? 22.16046  19.18941  0.96766   1.000 77.07283 ? 46  SER B CB  1 
ATOM   2653 O  OG  . SER B 1 46  ? 22.93983  20.31816  1.32000   1.000 82.80192 ? 46  SER B OG  1 
ATOM   2654 N  N   . GLU B 1 47  ? 23.34748  18.77964  3.96804   1.000 72.76038 ? 47  GLU B N   1 
ATOM   2655 C  CA  . GLU B 1 47  ? 24.40071  18.34529  4.87684   1.000 71.70544 ? 47  GLU B CA  1 
ATOM   2656 C  C   . GLU B 1 47  ? 23.86277  17.41598  5.95747   1.000 76.62876 ? 47  GLU B C   1 
ATOM   2657 O  O   . GLU B 1 47  ? 24.58831  16.53057  6.42515   1.000 72.09524 ? 47  GLU B O   1 
ATOM   2658 C  CB  . GLU B 1 47  ? 25.08129  19.55884  5.51295   1.000 69.48111 ? 47  GLU B CB  1 
ATOM   2659 N  N   . ASP B 1 48  ? 22.60421  17.60209  6.36707   1.000 74.64200 ? 48  ASP B N   1 
ATOM   2660 C  CA  . ASP B 1 48  ? 21.99735  16.68599  7.32718   1.000 66.88388 ? 48  ASP B CA  1 
ATOM   2661 C  C   . ASP B 1 48  ? 21.81815  15.29803  6.72633   1.000 71.23900 ? 48  ASP B C   1 
ATOM   2662 O  O   . ASP B 1 48  ? 22.03770  14.28924  7.40691   1.000 67.69714 ? 48  ASP B O   1 
ATOM   2663 C  CB  . ASP B 1 48  ? 20.65330  17.23393  7.80610   1.000 68.25264 ? 48  ASP B CB  1 
ATOM   2664 C  CG  . ASP B 1 48  ? 20.80340  18.35797  8.80963   1.000 74.15290 ? 48  ASP B CG  1 
ATOM   2665 O  OD1 . ASP B 1 48  ? 21.80381  18.36200  9.55755   1.000 80.16766 ? 48  ASP B OD1 1 
ATOM   2666 O  OD2 . ASP B 1 48  ? 19.91673  19.23639  8.85295   1.000 69.48314 ? 48  ASP B OD2 1 
ATOM   2667 N  N   . MET B 1 49  ? 21.42936  15.22639  5.44950   1.000 67.22448 ? 49  MET B N   1 
ATOM   2668 C  CA  . MET B 1 49  ? 21.18077  13.94365  4.79962   1.000 67.36261 ? 49  MET B CA  1 
ATOM   2669 C  C   . MET B 1 49  ? 22.42879  13.07988  4.67584   1.000 69.07968 ? 49  MET B C   1 
ATOM   2670 O  O   . MET B 1 49  ? 22.30368  11.89291  4.35615   1.000 65.14276 ? 49  MET B O   1 
ATOM   2671 C  CB  . MET B 1 49  ? 20.57901  14.16252  3.40873   1.000 67.04164 ? 49  MET B CB  1 
ATOM   2672 C  CG  . MET B 1 49  ? 19.10187  14.51867  3.40920   1.000 69.12942 ? 49  MET B CG  1 
ATOM   2673 S  SD  . MET B 1 49  ? 18.07001  13.22151  4.12286   1.000 60.33247 ? 49  MET B SD  1 
ATOM   2674 C  CE  . MET B 1 49  ? 18.54464  11.81532  3.12173   1.000 61.83664 ? 49  MET B CE  1 
ATOM   2675 N  N   . LEU B 1 50  ? 23.62022  13.63363  4.91401   1.000 71.71035 ? 50  LEU B N   1 
ATOM   2676 C  CA  . LEU B 1 50  ? 24.83637  12.83495  4.79107   1.000 69.69049 ? 50  LEU B CA  1 
ATOM   2677 C  C   . LEU B 1 50  ? 24.98986  11.86605  5.95813   1.000 67.31916 ? 50  LEU B C   1 
ATOM   2678 O  O   . LEU B 1 50  ? 25.46343  10.73804  5.77516   1.000 67.46971 ? 50  LEU B O   1 
ATOM   2679 C  CB  . LEU B 1 50  ? 26.05670  13.74816  4.67691   1.000 70.75417 ? 50  LEU B CB  1 
ATOM   2680 C  CG  . LEU B 1 50  ? 26.31943  14.30837  3.27910   1.000 72.97420 ? 50  LEU B CG  1 
ATOM   2681 C  CD1 . LEU B 1 50  ? 27.47132  15.29979  3.29950   1.000 70.58768 ? 50  LEU B CD1 1 
ATOM   2682 C  CD2 . LEU B 1 50  ? 26.60225  13.17743  2.29842   1.000 64.65721 ? 50  LEU B CD2 1 
ATOM   2683 N  N   . ASN B 1 51  ? 24.59864  12.28373  7.16018   1.000 65.01928 ? 51  ASN B N   1 
ATOM   2684 C  CA  . ASN B 1 51  ? 24.63199  11.41169  8.32724   1.000 68.89121 ? 51  ASN B CA  1 
ATOM   2685 C  C   . ASN B 1 51  ? 23.62265  11.91620  9.35097   1.000 66.83480 ? 51  ASN B C   1 
ATOM   2686 O  O   . ASN B 1 51  ? 24.00278  12.55728  10.33931  1.000 67.83142 ? 51  ASN B O   1 
ATOM   2687 C  CB  . ASN B 1 51  ? 26.03658  11.35593  8.92959   1.000 73.59814 ? 51  ASN B CB  1 
ATOM   2688 C  CG  . ASN B 1 51  ? 26.32125  10.03565  9.61790   1.000 70.71320 ? 51  ASN B CG  1 
ATOM   2689 O  OD1 . ASN B 1 51  ? 25.41705  9.23126   9.84079   1.000 72.19199 ? 51  ASN B OD1 1 
ATOM   2690 N  ND2 . ASN B 1 51  ? 27.58312  9.80659   9.95997   1.000 71.48560 ? 51  ASN B ND2 1 
ATOM   2691 N  N   . PRO B 1 52  ? 22.33401  11.64907  9.15154   1.000 66.90811 ? 52  PRO B N   1 
ATOM   2692 C  CA  . PRO B 1 52  ? 21.31123  12.28019  9.99165   1.000 57.93171 ? 52  PRO B CA  1 
ATOM   2693 C  C   . PRO B 1 52  ? 21.21013  11.64102  11.36632  1.000 57.09973 ? 52  PRO B C   1 
ATOM   2694 O  O   . PRO B 1 52  ? 21.29580  10.42019  11.51891  1.000 59.27332 ? 52  PRO B O   1 
ATOM   2695 C  CB  . PRO B 1 52  ? 20.01404  12.06524  9.19632   1.000 59.58848 ? 52  PRO B CB  1 
ATOM   2696 C  CG  . PRO B 1 52  ? 20.43154  11.52196  7.85466   1.000 62.79420 ? 52  PRO B CG  1 
ATOM   2697 C  CD  . PRO B 1 52  ? 21.73759  10.83889  8.07993   1.000 66.91680 ? 52  PRO B CD  1 
ATOM   2698 N  N   . ASN B 1 53  ? 21.03258  12.49148  12.37235  1.000 62.88725 ? 53  ASN B N   1 
ATOM   2699 C  CA  . ASN B 1 53  ? 20.60318  12.08876  13.70968  1.000 59.69635 ? 53  ASN B CA  1 
ATOM   2700 C  C   . ASN B 1 53  ? 19.15513  12.56000  13.81598  1.000 55.03437 ? 53  ASN B C   1 
ATOM   2701 O  O   . ASN B 1 53  ? 18.88344  13.69399  14.21277  1.000 58.55304 ? 53  ASN B O   1 
ATOM   2702 C  CB  . ASN B 1 53  ? 21.49225  12.69302  14.79879  1.000 59.75840 ? 53  ASN B CB  1 
ATOM   2703 C  CG  . ASN B 1 53  ? 21.16560  12.16382  16.18740  1.000 63.90426 ? 53  ASN B CG  1 
ATOM   2704 O  OD1 . ASN B 1 53  ? 20.05850  11.68977  16.44481  1.000 55.20855 ? 53  ASN B OD1 1 
ATOM   2705 N  ND2 . ASN B 1 53  ? 22.13387  12.24942  17.09254  1.000 68.13469 ? 53  ASN B ND2 1 
ATOM   2706 N  N   . TYR B 1 54  ? 18.22444  11.67619  13.44765  1.000 53.86866 ? 54  TYR B N   1 
ATOM   2707 C  CA  . TYR B 1 54  ? 16.84176  12.09852  13.24285  1.000 52.37785 ? 54  TYR B CA  1 
ATOM   2708 C  C   . TYR B 1 54  ? 16.18133  12.54135  14.54300  1.000 55.97339 ? 54  TYR B C   1 
ATOM   2709 O  O   . TYR B 1 54  ? 15.43419  13.52675  14.55561  1.000 51.51613 ? 54  TYR B O   1 
ATOM   2710 C  CB  . TYR B 1 54  ? 16.04229  10.97536  12.58304  1.000 47.04449 ? 54  TYR B CB  1 
ATOM   2711 C  CG  . TYR B 1 54  ? 16.23749  10.90362  11.08644  1.000 43.85789 ? 54  TYR B CG  1 
ATOM   2712 C  CD1 . TYR B 1 54  ? 15.59476  11.79977  10.24392  1.000 46.72897 ? 54  TYR B CD1 1 
ATOM   2713 C  CD2 . TYR B 1 54  ? 17.06831  9.94775   10.51650  1.000 37.59943 ? 54  TYR B CD2 1 
ATOM   2714 C  CE1 . TYR B 1 54  ? 15.76828  11.74411  8.87801   1.000 43.54613 ? 54  TYR B CE1 1 
ATOM   2715 C  CE2 . TYR B 1 54  ? 17.24509  9.88228   9.14864   1.000 48.71950 ? 54  TYR B CE2 1 
ATOM   2716 C  CZ  . TYR B 1 54  ? 16.59363  10.78457  8.33460   1.000 41.63688 ? 54  TYR B CZ  1 
ATOM   2717 O  OH  . TYR B 1 54  ? 16.76520  10.73030  6.97226   1.000 40.54056 ? 54  TYR B OH  1 
ATOM   2718 N  N   . GLU B 1 55  ? 16.43805  11.83450  15.64654  1.000 52.29797 ? 55  GLU B N   1 
ATOM   2719 C  CA  . GLU B 1 55  ? 15.80928  12.21744  16.90722  1.000 58.75368 ? 55  GLU B CA  1 
ATOM   2720 C  C   . GLU B 1 55  ? 16.31197  13.57569  17.38474  1.000 58.35966 ? 55  GLU B C   1 
ATOM   2721 O  O   . GLU B 1 55  ? 15.53739  14.37520  17.92273  1.000 58.85151 ? 55  GLU B O   1 
ATOM   2722 C  CB  . GLU B 1 55  ? 16.04160  11.13876  17.96710  1.000 62.32478 ? 55  GLU B CB  1 
ATOM   2723 C  CG  . GLU B 1 55  ? 17.49764  10.82803  18.26739  1.000 64.08904 ? 55  GLU B CG  1 
ATOM   2724 C  CD  . GLU B 1 55  ? 17.65139  9.67103   19.23618  1.000 66.22616 ? 55  GLU B CD  1 
ATOM   2725 O  OE1 . GLU B 1 55  ? 16.80436  8.75276   19.20312  1.000 55.09433 ? 55  GLU B OE1 1 
ATOM   2726 O  OE2 . GLU B 1 55  ? 18.61267  9.68222   20.03497  1.000 64.67162 ? 55  GLU B OE2 1 
ATOM   2727 N  N   . ASP B 1 56  ? 17.59893  13.86485  17.17792  1.000 64.04321 ? 56  ASP B N   1 
ATOM   2728 C  CA  . ASP B 1 56  ? 18.12370  15.17731  17.54123  1.000 64.70721 ? 56  ASP B CA  1 
ATOM   2729 C  C   . ASP B 1 56  ? 17.61784  16.25569  16.59158  1.000 61.58608 ? 56  ASP B C   1 
ATOM   2730 O  O   . ASP B 1 56  ? 17.24900  17.35225  17.02861  1.000 63.60065 ? 56  ASP B O   1 
ATOM   2731 C  CB  . ASP B 1 56  ? 19.65137  15.15173  17.55192  1.000 64.61267 ? 56  ASP B CB  1 
ATOM   2732 C  CG  . ASP B 1 56  ? 20.25192  16.50766  17.86603  1.000 67.98546 ? 56  ASP B CG  1 
ATOM   2733 O  OD1 . ASP B 1 56  ? 20.07890  16.98629  19.00727  1.000 65.94927 ? 56  ASP B OD1 1 
ATOM   2734 O  OD2 . ASP B 1 56  ? 20.89536  17.09685  16.97240  1.000 67.93601 ? 56  ASP B OD2 1 
ATOM   2735 N  N   . LEU B 1 57  ? 17.59810  15.96281  15.28831  1.000 63.01039 ? 57  LEU B N   1 
ATOM   2736 C  CA  . LEU B 1 57  ? 17.10789  16.93209  14.31319  1.000 56.21194 ? 57  LEU B CA  1 
ATOM   2737 C  C   . LEU B 1 57  ? 15.64816  17.28271  14.56780  1.000 50.96716 ? 57  LEU B C   1 
ATOM   2738 O  O   . LEU B 1 57  ? 15.25728  18.45212  14.47600  1.000 59.02429 ? 57  LEU B O   1 
ATOM   2739 C  CB  . LEU B 1 57  ? 17.28728  16.38560  12.89593  1.000 58.35702 ? 57  LEU B CB  1 
ATOM   2740 C  CG  . LEU B 1 57  ? 18.54758  16.77144  12.11672  1.000 62.24678 ? 57  LEU B CG  1 
ATOM   2741 C  CD1 . LEU B 1 57  ? 19.80683  16.54175  12.93783  1.000 71.12837 ? 57  LEU B CD1 1 
ATOM   2742 C  CD2 . LEU B 1 57  ? 18.61403  15.99339  10.81206  1.000 58.12788 ? 57  LEU B CD2 1 
ATOM   2743 N  N   . LEU B 1 58  ? 14.82748  16.28321  14.89645  1.000 57.68605 ? 58  LEU B N   1 
ATOM   2744 C  CA  . LEU B 1 58  ? 13.40873  16.53900  15.12120  1.000 57.29477 ? 58  LEU B CA  1 
ATOM   2745 C  C   . LEU B 1 58  ? 13.17527  17.26000  16.44344  1.000 60.06674 ? 58  LEU B C   1 
ATOM   2746 O  O   . LEU B 1 58  ? 12.26399  18.08986  16.55029  1.000 60.83459 ? 58  LEU B O   1 
ATOM   2747 C  CB  . LEU B 1 58  ? 12.62517  15.22766  15.07852  1.000 49.95492 ? 58  LEU B CB  1 
ATOM   2748 C  CG  . LEU B 1 58  ? 11.10763  15.37336  15.19513  1.000 50.78528 ? 58  LEU B CG  1 
ATOM   2749 C  CD1 . LEU B 1 58  ? 10.58737  16.29893  14.10893  1.000 61.67070 ? 58  LEU B CD1 1 
ATOM   2750 C  CD2 . LEU B 1 58  ? 10.42356  14.01803  15.12125  1.000 57.73049 ? 58  LEU B CD2 1 
ATOM   2751 N  N   . ILE B 1 59  ? 13.98325  16.95458  17.46239  1.000 60.24885 ? 59  ILE B N   1 
ATOM   2752 C  CA  . ILE B 1 59  ? 13.83666  17.62231  18.75405  1.000 62.09140 ? 59  ILE B CA  1 
ATOM   2753 C  C   . ILE B 1 59  ? 14.09616  19.11698  18.61394  1.000 63.56742 ? 59  ILE B C   1 
ATOM   2754 O  O   . ILE B 1 59  ? 13.40989  19.94252  19.22893  1.000 64.10790 ? 59  ILE B O   1 
ATOM   2755 C  CB  . ILE B 1 59  ? 14.76918  16.98095  19.79854  1.000 57.98621 ? 59  ILE B CB  1 
ATOM   2756 N  N   . ARG B 1 60  ? 15.08115  19.48935  17.79817  1.000 59.24034 ? 60  ARG B N   1 
ATOM   2757 C  CA  . ARG B 1 60  ? 15.40396  20.88884  17.55107  1.000 63.97476 ? 60  ARG B CA  1 
ATOM   2758 C  C   . ARG B 1 60  ? 14.48328  21.53912  16.52294  1.000 71.36994 ? 60  ARG B C   1 
ATOM   2759 O  O   . ARG B 1 60  ? 14.78889  22.63736  16.04586  1.000 65.28950 ? 60  ARG B O   1 
ATOM   2760 C  CB  . ARG B 1 60  ? 16.86138  21.01924  17.09834  1.000 55.76814 ? 60  ARG B CB  1 
ATOM   2761 N  N   . LYS B 1 61  ? 13.37593  20.89459  16.17093  1.000 73.33333 ? 61  LYS B N   1 
ATOM   2762 C  CA  . LYS B 1 61  ? 12.41254  21.43871  15.22830  1.000 76.00384 ? 61  LYS B CA  1 
ATOM   2763 C  C   . LYS B 1 61  ? 11.09952  21.74223  15.93621  1.000 72.36791 ? 61  LYS B C   1 
ATOM   2764 O  O   . LYS B 1 61  ? 10.79499  21.19277  16.99822  1.000 71.52273 ? 61  LYS B O   1 
ATOM   2765 C  CB  . LYS B 1 61  ? 12.17417  20.47344  14.06160  1.000 73.37656 ? 61  LYS B CB  1 
ATOM   2766 C  CG  . LYS B 1 61  ? 13.21870  20.57261  12.96438  1.000 68.04871 ? 61  LYS B CG  1 
ATOM   2767 C  CD  . LYS B 1 61  ? 12.59609  21.03117  11.65706  1.000 65.47179 ? 61  LYS B CD  1 
ATOM   2768 C  CE  . LYS B 1 61  ? 13.65129  21.56422  10.70276  1.000 67.89235 ? 61  LYS B CE  1 
ATOM   2769 N  NZ  . LYS B 1 61  ? 14.75883  20.59266  10.48891  1.000 70.54969 ? 61  LYS B NZ  1 
ATOM   2770 N  N   . SER B 1 62  ? 10.32107  22.62921  15.32617  1.000 70.61617 ? 62  SER B N   1 
ATOM   2771 C  CA  . SER B 1 62  ? 9.08128   23.11932  15.90205  1.000 71.03321 ? 62  SER B CA  1 
ATOM   2772 C  C   . SER B 1 62  ? 7.91311   22.81218  14.97549  1.000 74.23848 ? 62  SER B C   1 
ATOM   2773 O  O   . SER B 1 62  ? 8.09224   22.52739  13.78809  1.000 75.33048 ? 62  SER B O   1 
ATOM   2774 C  CB  . SER B 1 62  ? 9.15895   24.63040  16.16078  1.000 71.50000 ? 62  SER B CB  1 
ATOM   2775 O  OG  . SER B 1 62  ? 7.89715   25.15280  16.53471  1.000 75.19663 ? 62  SER B OG  1 
ATOM   2776 N  N   . ASN B 1 63  ? 6.70269   22.87343  15.54047  1.000 66.83950 ? 63  ASN B N   1 
ATOM   2777 C  CA  . ASN B 1 63  ? 5.49304   22.81620  14.72728  1.000 67.95385 ? 63  ASN B CA  1 
ATOM   2778 C  C   . ASN B 1 63  ? 5.48702   23.89100  13.65253  1.000 72.11886 ? 63  ASN B C   1 
ATOM   2779 O  O   . ASN B 1 63  ? 4.81294   23.73374  12.62803  1.000 70.37821 ? 63  ASN B O   1 
ATOM   2780 C  CB  . ASN B 1 63  ? 4.24965   22.97627  15.60770  1.000 56.07995 ? 63  ASN B CB  1 
ATOM   2781 C  CG  . ASN B 1 63  ? 4.01850   21.78967  16.51811  1.000 62.01213 ? 63  ASN B CG  1 
ATOM   2782 O  OD1 . ASN B 1 63  ? 4.80629   20.84636  16.54146  1.000 66.70722 ? 63  ASN B OD1 1 
ATOM   2783 N  ND2 . ASN B 1 63  ? 2.93266   21.83416  17.28064  1.000 63.76610 ? 63  ASN B ND2 1 
ATOM   2784 N  N   . HIS B 1 64  ? 6.22633   24.97792  13.86767  1.000 69.38017 ? 64  HIS B N   1 
ATOM   2785 C  CA  . HIS B 1 64  ? 6.27058   26.10279  12.94787  1.000 72.66017 ? 64  HIS B CA  1 
ATOM   2786 C  C   . HIS B 1 64  ? 7.26520   25.90165  11.81379  1.000 69.85057 ? 64  HIS B C   1 
ATOM   2787 O  O   . HIS B 1 64  ? 7.28878   26.71173  10.88096  1.000 77.94428 ? 64  HIS B O   1 
ATOM   2788 C  CB  . HIS B 1 64  ? 6.60073   27.37308  13.73102  1.000 72.03106 ? 64  HIS B CB  1 
ATOM   2789 C  CG  . HIS B 1 64  ? 5.87859   27.46894  15.03837  1.000 71.98521 ? 64  HIS B CG  1 
ATOM   2790 N  ND1 . HIS B 1 64  ? 6.50616   27.28202  16.25132  1.000 72.52553 ? 64  HIS B ND1 1 
ATOM   2791 C  CD2 . HIS B 1 64  ? 4.57520   27.70258  15.32106  1.000 69.53513 ? 64  HIS B CD2 1 
ATOM   2792 C  CE1 . HIS B 1 64  ? 5.62340   27.41099  17.22564  1.000 73.55719 ? 64  HIS B CE1 1 
ATOM   2793 N  NE2 . HIS B 1 64  ? 4.44403   27.66616  16.68809  1.000 75.12927 ? 64  HIS B NE2 1 
ATOM   2794 N  N   . ASN B 1 65  ? 8.08245   24.85262  11.87004  1.000 67.23811 ? 65  ASN B N   1 
ATOM   2795 C  CA  . ASN B 1 65  ? 8.93069   24.48552  10.74505  1.000 71.59831 ? 65  ASN B CA  1 
ATOM   2796 C  C   . ASN B 1 65  ? 8.19309   23.65532  9.70431   1.000 61.93778 ? 65  ASN B C   1 
ATOM   2797 O  O   . ASN B 1 65  ? 8.81542   23.21784  8.73127   1.000 66.72229 ? 65  ASN B O   1 
ATOM   2798 C  CB  . ASN B 1 65  ? 10.15978  23.71230  11.23365  1.000 74.00240 ? 65  ASN B CB  1 
ATOM   2799 C  CG  . ASN B 1 65  ? 11.07998  24.55593  12.09205  1.000 75.13467 ? 65  ASN B CG  1 
ATOM   2800 O  OD1 . ASN B 1 65  ? 11.37519  24.20479  13.23453  1.000 78.75098 ? 65  ASN B OD1 1 
ATOM   2801 N  ND2 . ASN B 1 65  ? 11.54442  25.67307  11.54300  1.000 76.84315 ? 65  ASN B ND2 1 
ATOM   2802 N  N   . PHE B 1 66  ? 6.89286   23.42907  9.88260   1.000 66.50030 ? 66  PHE B N   1 
ATOM   2803 C  CA  . PHE B 1 66  ? 6.10431   22.57746  8.99796   1.000 62.66567 ? 66  PHE B CA  1 
ATOM   2804 C  C   . PHE B 1 66  ? 4.94382   23.38630  8.43468   1.000 63.92818 ? 66  PHE B C   1 
ATOM   2805 O  O   . PHE B 1 66  ? 4.01951   23.75302  9.16896   1.000 66.51495 ? 66  PHE B O   1 
ATOM   2806 C  CB  . PHE B 1 66  ? 5.60301   21.33933  9.73857   1.000 61.31801 ? 66  PHE B CB  1 
ATOM   2807 C  CG  . PHE B 1 66  ? 6.70463   20.46064  10.25265  1.000 63.63349 ? 66  PHE B CG  1 
ATOM   2808 C  CD1 . PHE B 1 66  ? 7.47814   19.72044  9.37560   1.000 56.82007 ? 66  PHE B CD1 1 
ATOM   2809 C  CD2 . PHE B 1 66  ? 6.97020   20.37558  11.61021  1.000 59.75233 ? 66  PHE B CD2 1 
ATOM   2810 C  CE1 . PHE B 1 66  ? 8.49781   18.91288  9.83974   1.000 63.56919 ? 66  PHE B CE1 1 
ATOM   2811 C  CE2 . PHE B 1 66  ? 7.98858   19.56729  12.08206  1.000 61.92156 ? 66  PHE B CE2 1 
ATOM   2812 C  CZ  . PHE B 1 66  ? 8.75279   18.83461  11.19528  1.000 69.34342 ? 66  PHE B CZ  1 
ATOM   2813 N  N   . LEU B 1 67  ? 4.99558   23.65983  7.13465   1.000 61.21574 ? 67  LEU B N   1 
ATOM   2814 C  CA  . LEU B 1 67  ? 3.92323   24.34104  6.42300   1.000 58.63133 ? 67  LEU B CA  1 
ATOM   2815 C  C   . LEU B 1 67  ? 3.16422   23.30616  5.60066   1.000 58.55883 ? 67  LEU B C   1 
ATOM   2816 O  O   . LEU B 1 67  ? 3.75383   22.63126  4.74900   1.000 56.38764 ? 67  LEU B O   1 
ATOM   2817 C  CB  . LEU B 1 67  ? 4.48450   25.44730  5.52979   1.000 61.64796 ? 67  LEU B CB  1 
ATOM   2818 C  CG  . LEU B 1 67  ? 3.49500   26.46683  4.96581   1.000 71.12183 ? 67  LEU B CG  1 
ATOM   2819 C  CD1 . LEU B 1 67  ? 2.80316   27.21682  6.09294   1.000 68.20693 ? 67  LEU B CD1 1 
ATOM   2820 C  CD2 . LEU B 1 67  ? 4.20150   27.43509  4.02859   1.000 76.45081 ? 67  LEU B CD2 1 
ATOM   2821 N  N   . VAL B 1 68  ? 1.86687   23.17509  5.86161   1.000 58.05820 ? 68  VAL B N   1 
ATOM   2822 C  CA  . VAL B 1 68  ? 1.03375   22.15260  5.23914   1.000 53.18718 ? 68  VAL B CA  1 
ATOM   2823 C  C   . VAL B 1 68  ? -0.05296  22.85500  4.43908   1.000 58.74010 ? 68  VAL B C   1 
ATOM   2824 O  O   . VAL B 1 68  ? -0.91013  23.54180  5.01028   1.000 56.70275 ? 68  VAL B O   1 
ATOM   2825 C  CB  . VAL B 1 68  ? 0.42511   21.19903  6.27438   1.000 47.64749 ? 68  VAL B CB  1 
ATOM   2826 C  CG1 . VAL B 1 68  ? -0.44619  20.16194  5.58672   1.000 54.27728 ? 68  VAL B CG1 1 
ATOM   2827 C  CG2 . VAL B 1 68  ? 1.52263   20.52685  7.07770   1.000 48.08044 ? 68  VAL B CG2 1 
ATOM   2828 N  N   . GLN B 1 69  ? -0.02514  22.67854  3.12105   1.000 60.38124 ? 69  GLN B N   1 
ATOM   2829 C  CA  . GLN B 1 69  ? -0.99780  23.27951  2.21815   1.000 57.20938 ? 69  GLN B CA  1 
ATOM   2830 C  C   . GLN B 1 69  ? -1.85987  22.17847  1.61601   1.000 54.48212 ? 69  GLN B C   1 
ATOM   2831 O  O   . GLN B 1 69  ? -1.34456  21.28434  0.93536   1.000 50.89332 ? 69  GLN B O   1 
ATOM   2832 C  CB  . GLN B 1 69  ? -0.30183  24.08074  1.11765   1.000 59.68869 ? 69  GLN B CB  1 
ATOM   2833 N  N   . ALA B 1 70  ? -3.16395  22.24275  1.87329   1.000 53.64099 ? 70  ALA B N   1 
ATOM   2834 C  CA  . ALA B 1 70  ? -4.14602  21.33695  1.28123   1.000 50.70117 ? 70  ALA B CA  1 
ATOM   2835 C  C   . ALA B 1 70  ? -4.90744  22.12692  0.22134   1.000 57.57418 ? 70  ALA B C   1 
ATOM   2836 O  O   . ALA B 1 70  ? -5.84286  22.86824  0.53766   1.000 65.17689 ? 70  ALA B O   1 
ATOM   2837 C  CB  . ALA B 1 70  ? -5.08123  20.76790  2.34342   1.000 51.72385 ? 70  ALA B CB  1 
ATOM   2838 N  N   . GLY B 1 71  ? -4.50460  21.96475  -1.03667  1.000 69.67737 ? 71  GLY B N   1 
ATOM   2839 C  CA  . GLY B 1 71  ? -5.02433  22.79863  -2.10113  1.000 60.82245 ? 71  GLY B CA  1 
ATOM   2840 C  C   . GLY B 1 71  ? -4.56796  24.23259  -1.93417  1.000 64.86437 ? 71  GLY B C   1 
ATOM   2841 O  O   . GLY B 1 71  ? -3.39763  24.55095  -2.16628  1.000 68.56258 ? 71  GLY B O   1 
ATOM   2842 N  N   . ASN B 1 72  ? -5.48462  25.10714  -1.52113  1.000 69.00151 ? 72  ASN B N   1 
ATOM   2843 C  CA  . ASN B 1 72  ? -5.15367  26.48616  -1.18428  1.000 76.29766 ? 72  ASN B CA  1 
ATOM   2844 C  C   . ASN B 1 72  ? -5.44996  26.80429  0.27589   1.000 73.01285 ? 72  ASN B C   1 
ATOM   2845 O  O   . ASN B 1 72  ? -5.36835  27.97214  0.67601   1.000 75.08010 ? 72  ASN B O   1 
ATOM   2846 C  CB  . ASN B 1 72  ? -5.90824  27.45684  -2.09860  1.000 70.09295 ? 72  ASN B CB  1 
ATOM   2847 N  N   . VAL B 1 73  ? -5.78475  25.79832  1.07987   1.000 67.27548 ? 73  VAL B N   1 
ATOM   2848 C  CA  . VAL B 1 73  ? -6.16303  25.97880  2.47657   1.000 63.97256 ? 73  VAL B CA  1 
ATOM   2849 C  C   . VAL B 1 73  ? -5.00921  25.50403  3.34836   1.000 71.07660 ? 73  VAL B C   1 
ATOM   2850 O  O   . VAL B 1 73  ? -4.60167  24.33769  3.27311   1.000 69.05473 ? 73  VAL B O   1 
ATOM   2851 C  CB  . VAL B 1 73  ? -7.45578  25.22123  2.81287   1.000 68.73246 ? 73  VAL B CB  1 
ATOM   2852 C  CG1 . VAL B 1 73  ? -7.76905  25.34404  4.29387   1.000 67.43017 ? 73  VAL B CG1 1 
ATOM   2853 C  CG2 . VAL B 1 73  ? -8.60899  25.74514  1.97001   1.000 65.09584 ? 73  VAL B CG2 1 
ATOM   2854 N  N   . GLN B 1 74  ? -4.48726  26.40489  4.17613   1.000 64.92251 ? 74  GLN B N   1 
ATOM   2855 C  CA  . GLN B 1 74  ? -3.39263  26.05931  5.06936   1.000 59.75680 ? 74  GLN B CA  1 
ATOM   2856 C  C   . GLN B 1 74  ? -3.89168  25.19816  6.22368   1.000 60.13213 ? 74  GLN B C   1 
ATOM   2857 O  O   . GLN B 1 74  ? -5.01090  25.36379  6.71510   1.000 69.24599 ? 74  GLN B O   1 
ATOM   2858 C  CB  . GLN B 1 74  ? -2.72733  27.32437  5.61156   1.000 62.71409 ? 74  GLN B CB  1 
ATOM   2859 C  CG  . GLN B 1 74  ? -1.21244  27.24134  5.69777   1.000 73.12959 ? 74  GLN B CG  1 
ATOM   2860 C  CD  . GLN B 1 74  ? -0.54755  27.35149  4.33975   1.000 76.61692 ? 74  GLN B CD  1 
ATOM   2861 O  OE1 . GLN B 1 74  ? -0.71723  28.34471  3.63114   1.000 78.91110 ? 74  GLN B OE1 1 
ATOM   2862 N  NE2 . GLN B 1 74  ? 0.21101   26.32718  3.96721   1.000 72.32611 ? 74  GLN B NE2 1 
ATOM   2863 N  N   . LEU B 1 75  ? -3.04419  24.26651  6.65355   1.000 64.33001 ? 75  LEU B N   1 
ATOM   2864 C  CA  . LEU B 1 75  ? -3.34288  23.37816  7.76995   1.000 67.34705 ? 75  LEU B CA  1 
ATOM   2865 C  C   . LEU B 1 75  ? -2.33990  23.64142  8.88315   1.000 68.81254 ? 75  LEU B C   1 
ATOM   2866 O  O   . LEU B 1 75  ? -1.12949  23.49495  8.68008   1.000 60.58357 ? 75  LEU B O   1 
ATOM   2867 C  CB  . LEU B 1 75  ? -3.29665  21.91090  7.33898   1.000 63.22503 ? 75  LEU B CB  1 
ATOM   2868 C  CG  . LEU B 1 75  ? -4.40680  21.43481  6.40043   1.000 59.99319 ? 75  LEU B CG  1 
ATOM   2869 C  CD1 . LEU B 1 75  ? -4.24934  19.95301  6.09069   1.000 60.56081 ? 75  LEU B CD1 1 
ATOM   2870 C  CD2 . LEU B 1 75  ? -5.76849  21.71789  7.00948   1.000 56.11053 ? 75  LEU B CD2 1 
ATOM   2871 N  N   . ARG B 1 76  ? -2.84262  24.02035  10.05572  1.000 68.90159 ? 76  ARG B N   1 
ATOM   2872 C  CA  . ARG B 1 76  ? -1.98409  24.34872  11.18714  1.000 63.03960 ? 76  ARG B CA  1 
ATOM   2873 C  C   . ARG B 1 76  ? -1.50628  23.06706  11.85794  1.000 57.50285 ? 76  ARG B C   1 
ATOM   2874 O  O   . ARG B 1 76  ? -2.32045  22.25693  12.31583  1.000 53.63042 ? 76  ARG B O   1 
ATOM   2875 C  CB  . ARG B 1 76  ? -2.72900  25.23465  12.18381  1.000 62.21674 ? 76  ARG B CB  1 
ATOM   2876 N  N   . VAL B 1 77  ? -0.19067  22.88404  11.91278  1.000 63.11978 ? 77  VAL B N   1 
ATOM   2877 C  CA  . VAL B 1 77  ? 0.39646   21.72855  12.58242  1.000 60.06776 ? 77  VAL B CA  1 
ATOM   2878 C  C   . VAL B 1 77  ? 0.35710   21.97095  14.08638  1.000 60.52579 ? 77  VAL B C   1 
ATOM   2879 O  O   . VAL B 1 77  ? 0.98725   22.90631  14.59142  1.000 63.87644 ? 77  VAL B O   1 
ATOM   2880 C  CB  . VAL B 1 77  ? 1.83182   21.47733  12.09947  1.000 59.39729 ? 77  VAL B CB  1 
ATOM   2881 C  CG1 . VAL B 1 77  ? 2.36522   20.17129  12.66687  1.000 58.46568 ? 77  VAL B CG1 1 
ATOM   2882 C  CG2 . VAL B 1 77  ? 1.88653   21.46991  10.58479  1.000 61.83932 ? 77  VAL B CG2 1 
ATOM   2883 N  N   . ILE B 1 78  ? -0.38294  21.12763  14.80634  1.000 58.30668 ? 78  ILE B N   1 
ATOM   2884 C  CA  . ILE B 1 78  ? -0.52994  21.26383  16.25103  1.000 58.49478 ? 78  ILE B CA  1 
ATOM   2885 C  C   . ILE B 1 78  ? 0.30256   20.23517  17.00942  1.000 65.76892 ? 78  ILE B C   1 
ATOM   2886 O  O   . ILE B 1 78  ? 0.22925   20.17140  18.23946  1.000 66.32193 ? 78  ILE B O   1 
ATOM   2887 C  CB  . ILE B 1 78  ? -2.00719  21.18337  16.66763  1.000 55.32796 ? 78  ILE B CB  1 
ATOM   2888 C  CG1 . ILE B 1 78  ? -2.56559  19.78614  16.39220  1.000 56.80422 ? 78  ILE B CG1 1 
ATOM   2889 C  CG2 . ILE B 1 78  ? -2.82092  22.22904  15.92598  1.000 59.71255 ? 78  ILE B CG2 1 
ATOM   2890 C  CD1 . ILE B 1 78  ? -3.94588  19.55819  16.96685  1.000 53.32892 ? 78  ILE B CD1 1 
ATOM   2891 N  N   . GLY B 1 79  ? 1.09819   19.43391  16.30559  1.000 62.63682 ? 79  GLY B N   1 
ATOM   2892 C  CA  . GLY B 1 79  ? 1.92070   18.42588  16.94369  1.000 58.14633 ? 79  GLY B CA  1 
ATOM   2893 C  C   . GLY B 1 79  ? 2.60329   17.51797  15.94215  1.000 56.97079 ? 79  GLY B C   1 
ATOM   2894 O  O   . GLY B 1 79  ? 2.12781   17.37186  14.81238  1.000 54.91699 ? 79  GLY B O   1 
ATOM   2895 N  N   . HIS B 1 80  ? 3.71098   16.89373  16.33883  1.000 49.39464 ? 80  HIS B N   1 
ATOM   2896 C  CA  . HIS B 1 80  ? 4.49619   16.09434  15.41099  1.000 51.11933 ? 80  HIS B CA  1 
ATOM   2897 C  C   . HIS B 1 80  ? 5.21510   14.98910  16.16878  1.000 53.55657 ? 80  HIS B C   1 
ATOM   2898 O  O   . HIS B 1 80  ? 5.58126   15.15309  17.33553  1.000 52.16847 ? 80  HIS B O   1 
ATOM   2899 C  CB  . HIS B 1 80  ? 5.50492   16.95980  14.64790  1.000 51.58600 ? 80  HIS B CB  1 
ATOM   2900 C  CG  . HIS B 1 80  ? 6.49617   17.65218  15.52984  1.000 62.53085 ? 80  HIS B CG  1 
ATOM   2901 N  ND1 . HIS B 1 80  ? 6.16700   18.73616  16.31517  1.000 73.93442 ? 80  HIS B ND1 1 
ATOM   2902 C  CD2 . HIS B 1 80  ? 7.81078   17.41456  15.74943  1.000 68.63403 ? 80  HIS B CD2 1 
ATOM   2903 C  CE1 . HIS B 1 80  ? 7.23633   19.13555  16.98104  1.000 75.42736 ? 80  HIS B CE1 1 
ATOM   2904 N  NE2 . HIS B 1 80  ? 8.24730   18.35079  16.65498  1.000 73.03981 ? 80  HIS B NE2 1 
ATOM   2905 N  N   . SER B 1 81  ? 5.41067   13.85966  15.49008  1.000 51.64111 ? 81  SER B N   1 
ATOM   2906 C  CA  . SER B 1 81  ? 6.12822   12.73038  16.06571  1.000 48.42995 ? 81  SER B CA  1 
ATOM   2907 C  C   . SER B 1 81  ? 6.58621   11.80967  14.94333  1.000 45.30827 ? 81  SER B C   1 
ATOM   2908 O  O   . SER B 1 81  ? 6.03911   11.82548  13.83743  1.000 40.47022 ? 81  SER B O   1 
ATOM   2909 C  CB  . SER B 1 81  ? 5.26357   11.96306  17.07176  1.000 31.97873 ? 81  SER B CB  1 
ATOM   2910 O  OG  . SER B 1 81  ? 4.15628   11.35941  16.42941  1.000 40.99745 ? 81  SER B OG  1 
ATOM   2911 N  N   . MET B 1 82  ? 7.60016   11.00478  15.25070  1.000 44.28649 ? 82  MET B N   1 
ATOM   2912 C  CA  . MET B 1 82  ? 8.18809   10.06025  14.31065  1.000 32.89818 ? 82  MET B CA  1 
ATOM   2913 C  C   . MET B 1 82  ? 7.74525   8.64178   14.64490  1.000 35.77784 ? 82  MET B C   1 
ATOM   2914 O  O   . MET B 1 82  ? 7.79625   8.22812   15.80750  1.000 38.51022 ? 82  MET B O   1 
ATOM   2915 C  CB  . MET B 1 82  ? 9.71500   10.13220  14.35266  1.000 38.64967 ? 82  MET B CB  1 
ATOM   2916 C  CG  . MET B 1 82  ? 10.36633  10.84761  13.18802  1.000 38.04330 ? 82  MET B CG  1 
ATOM   2917 S  SD  . MET B 1 82  ? 12.14870  10.57456  13.18974  1.000 55.66523 ? 82  MET B SD  1 
ATOM   2918 C  CE  . MET B 1 82  ? 12.56915  11.02685  14.87104  1.000 54.07277 ? 82  MET B CE  1 
ATOM   2919 N  N   . GLN B 1 83  ? 7.32096   7.89891   13.62706  1.000 37.56525 ? 83  GLN B N   1 
ATOM   2920 C  CA  . GLN B 1 83  ? 7.19829   6.44759   13.71389  1.000 33.22315 ? 83  GLN B CA  1 
ATOM   2921 C  C   . GLN B 1 83  ? 8.13164   5.85815   12.66700  1.000 35.22004 ? 83  GLN B C   1 
ATOM   2922 O  O   . GLN B 1 83  ? 7.83949   5.91610   11.46716  1.000 33.40231 ? 83  GLN B O   1 
ATOM   2923 C  CB  . GLN B 1 83  ? 5.76286   5.97135   13.49936  1.000 35.45854 ? 83  GLN B CB  1 
ATOM   2924 C  CG  . GLN B 1 83  ? 5.66129   4.45014   13.44161  1.000 30.00550 ? 83  GLN B CG  1 
ATOM   2925 C  CD  . GLN B 1 83  ? 4.23706   3.94130   13.41074  1.000 36.76018 ? 83  GLN B CD  1 
ATOM   2926 O  OE1 . GLN B 1 83  ? 3.29376   4.70406   13.20797  1.000 40.17453 ? 83  GLN B OE1 1 
ATOM   2927 N  NE2 . GLN B 1 83  ? 4.07367   2.63952   13.61796  1.000 43.34065 ? 83  GLN B NE2 1 
ATOM   2928 N  N   . ASN B 1 84  ? 9.25196   5.29980   13.12467  1.000 32.29442 ? 84  ASN B N   1 
ATOM   2929 C  CA  . ASN B 1 84  ? 10.28520  4.78036   12.23858  1.000 30.43788 ? 84  ASN B CA  1 
ATOM   2930 C  C   . ASN B 1 84  ? 10.73184  5.86283   11.26234  1.000 32.08290 ? 84  ASN B C   1 
ATOM   2931 O  O   . ASN B 1 84  ? 11.19201  6.92924   11.68342  1.000 38.12029 ? 84  ASN B O   1 
ATOM   2932 C  CB  . ASN B 1 84  ? 9.78424   3.53430   11.50297  1.000 28.25681 ? 84  ASN B CB  1 
ATOM   2933 C  CG  . ASN B 1 84  ? 9.49347   2.37825   12.44804  1.000 34.19921 ? 84  ASN B CG  1 
ATOM   2934 O  OD1 . ASN B 1 84  ? 10.28954  2.07253   13.33707  1.000 33.52990 ? 84  ASN B OD1 1 
ATOM   2935 N  ND2 . ASN B 1 84  ? 8.34615   1.73536   12.26390  1.000 33.95735 ? 84  ASN B ND2 1 
ATOM   2936 N  N   . CYS B 1 85  ? 10.58772  5.61330   9.96333   1.000 35.06394 ? 85  CYS B N   1 
ATOM   2937 C  CA  . CYS B 1 85  ? 11.03837  6.54981   8.94266   1.000 35.62290 ? 85  CYS B CA  1 
ATOM   2938 C  C   . CYS B 1 85  ? 9.93368   7.47367   8.44008   1.000 31.25242 ? 85  CYS B C   1 
ATOM   2939 O  O   . CYS B 1 85  ? 10.15405  8.20926   7.47244   1.000 31.03337 ? 85  CYS B O   1 
ATOM   2940 C  CB  . CYS B 1 85  ? 11.65031  5.78894   7.76508   1.000 33.62572 ? 85  CYS B CB  1 
ATOM   2941 S  SG  . CYS B 1 85  ? 13.11673  4.82309   8.18665   1.000 35.26677 ? 85  CYS B SG  1 
ATOM   2942 N  N   . VAL B 1 86  ? 8.76412   7.46701   9.07232   1.000 27.98207 ? 86  VAL B N   1 
ATOM   2943 C  CA  . VAL B 1 86  ? 7.63581   8.28829   8.65013   1.000 37.87535 ? 86  VAL B CA  1 
ATOM   2944 C  C   . VAL B 1 86  ? 7.37831   9.35753   9.70186   1.000 38.80932 ? 86  VAL B C   1 
ATOM   2945 O  O   . VAL B 1 86  ? 7.25312   9.05294   10.89489  1.000 36.52342 ? 86  VAL B O   1 
ATOM   2946 C  CB  . VAL B 1 86  ? 6.37861   7.43681   8.40440   1.000 36.11551 ? 86  VAL B CB  1 
ATOM   2947 C  CG1 . VAL B 1 86  ? 5.12032   8.28049   8.56611   1.000 30.31175 ? 86  VAL B CG1 1 
ATOM   2948 C  CG2 . VAL B 1 86  ? 6.43093   6.83686   7.01155   1.000 30.31395 ? 86  VAL B CG2 1 
ATOM   2949 N  N   . LEU B 1 87  ? 7.30035   10.60795  9.25570   1.000 40.38353 ? 87  LEU B N   1 
ATOM   2950 C  CA  . LEU B 1 87  ? 6.94777   11.72631  10.11692  1.000 36.78410 ? 87  LEU B CA  1 
ATOM   2951 C  C   . LEU B 1 87  ? 5.43301   11.89508  10.13914  1.000 41.59222 ? 87  LEU B C   1 
ATOM   2952 O  O   . LEU B 1 87  ? 4.79111   11.94279  9.08410   1.000 39.38206 ? 87  LEU B O   1 
ATOM   2953 C  CB  . LEU B 1 87  ? 7.62201   13.00577  9.62233   1.000 35.72132 ? 87  LEU B CB  1 
ATOM   2954 C  CG  . LEU B 1 87  ? 7.45549   14.28898  10.43452  1.000 44.93465 ? 87  LEU B CG  1 
ATOM   2955 C  CD1 . LEU B 1 87  ? 7.93077   14.08847  11.86425  1.000 44.03310 ? 87  LEU B CD1 1 
ATOM   2956 C  CD2 . LEU B 1 87  ? 8.22714   15.41522  9.76964   1.000 46.36210 ? 87  LEU B CD2 1 
ATOM   2957 N  N   . LYS B 1 88  ? 4.86533   11.97372  11.33895  1.000 39.01667 ? 88  LYS B N   1 
ATOM   2958 C  CA  . LYS B 1 88  ? 3.43827   12.19697  11.52368  1.000 36.94314 ? 88  LYS B CA  1 
ATOM   2959 C  C   . LYS B 1 88  ? 3.21966   13.61602  12.03111  1.000 46.81126 ? 88  LYS B C   1 
ATOM   2960 O  O   . LYS B 1 88  ? 3.87394   14.04662  12.98668  1.000 49.18110 ? 88  LYS B O   1 
ATOM   2961 C  CB  . LYS B 1 88  ? 2.84017   11.17561  12.49569  1.000 37.76103 ? 88  LYS B CB  1 
ATOM   2962 C  CG  . LYS B 1 88  ? 2.88400   9.74292   11.98253  1.000 42.72967 ? 88  LYS B CG  1 
ATOM   2963 C  CD  . LYS B 1 88  ? 2.06608   8.79748   12.85042  1.000 40.58857 ? 88  LYS B CD  1 
ATOM   2964 C  CE  . LYS B 1 88  ? 2.68709   8.61273   14.22393  1.000 42.46530 ? 88  LYS B CE  1 
ATOM   2965 N  NZ  . LYS B 1 88  ? 1.94408   7.60214   15.02779  1.000 52.13044 ? 88  LYS B NZ  1 
ATOM   2966 N  N   . LEU B 1 89  ? 2.30937   14.34033  11.38522  1.000 41.62423 ? 89  LEU B N   1 
ATOM   2967 C  CA  . LEU B 1 89  ? 2.03822   15.73930  11.69917  1.000 40.32063 ? 89  LEU B CA  1 
ATOM   2968 C  C   . LEU B 1 89  ? 0.56576   15.87570  12.05905  1.000 45.96995 ? 89  LEU B C   1 
ATOM   2969 O  O   . LEU B 1 89  ? -0.30265  15.78688  11.18439  1.000 50.44207 ? 89  LEU B O   1 
ATOM   2970 C  CB  . LEU B 1 89  ? 2.39704   16.64626  10.52207  1.000 44.69854 ? 89  LEU B CB  1 
ATOM   2971 C  CG  . LEU B 1 89  ? 3.84193   16.61088  10.02277  1.000 42.71157 ? 89  LEU B CG  1 
ATOM   2972 C  CD1 . LEU B 1 89  ? 3.95486   17.29208  8.66627   1.000 38.77456 ? 89  LEU B CD1 1 
ATOM   2973 C  CD2 . LEU B 1 89  ? 4.77373   17.26452  11.02903  1.000 53.10685 ? 89  LEU B CD2 1 
ATOM   2974 N  N   . LYS B 1 90  ? 0.28707   16.08580  13.34167  1.000 53.06901 ? 90  LYS B N   1 
ATOM   2975 C  CA  . LYS B 1 90  ? -1.07885  16.33203  13.77740  1.000 51.96247 ? 90  LYS B CA  1 
ATOM   2976 C  C   . LYS B 1 90  ? -1.52827  17.71176  13.31361  1.000 53.68063 ? 90  LYS B C   1 
ATOM   2977 O  O   . LYS B 1 90  ? -0.79152  18.69482  13.43177  1.000 50.43532 ? 90  LYS B O   1 
ATOM   2978 C  CB  . LYS B 1 90  ? -1.17561  16.22584  15.29891  1.000 47.15730 ? 90  LYS B CB  1 
ATOM   2979 C  CG  . LYS B 1 90  ? -2.59121  16.11542  15.84557  1.000 54.85844 ? 90  LYS B CG  1 
ATOM   2980 C  CD  . LYS B 1 90  ? -3.04073  14.66292  15.94401  1.000 59.75538 ? 90  LYS B CD  1 
ATOM   2981 C  CE  . LYS B 1 90  ? -4.27948  14.52261  16.82112  1.000 61.90859 ? 90  LYS B CE  1 
ATOM   2982 N  NZ  . LYS B 1 90  ? -4.71893  13.10419  16.96445  1.000 61.65690 ? 90  LYS B NZ  1 
ATOM   2983 N  N   . VAL B 1 91  ? -2.74162  17.78105  12.77123  1.000 55.93468 ? 91  VAL B N   1 
ATOM   2984 C  CA  . VAL B 1 91  ? -3.30533  19.02773  12.27659  1.000 55.82721 ? 91  VAL B CA  1 
ATOM   2985 C  C   . VAL B 1 91  ? -4.59859  19.31712  13.03122  1.000 53.76249 ? 91  VAL B C   1 
ATOM   2986 O  O   . VAL B 1 91  ? -5.12953  18.47335  13.75379  1.000 57.28413 ? 91  VAL B O   1 
ATOM   2987 C  CB  . VAL B 1 91  ? -3.54926  18.99860  10.75585  1.000 56.32715 ? 91  VAL B CB  1 
ATOM   2988 C  CG1 . VAL B 1 91  ? -2.22648  18.89084  10.01311  1.000 48.85528 ? 91  VAL B CG1 1 
ATOM   2989 C  CG2 . VAL B 1 91  ? -4.47071  17.84715  10.39022  1.000 51.69606 ? 91  VAL B CG2 1 
ATOM   2990 N  N   . ASP B 1 92  ? -5.10416  20.53810  12.84589  1.000 62.45855 ? 92  ASP B N   1 
ATOM   2991 C  CA  . ASP B 1 92  ? -6.28185  20.97566  13.58802  1.000 64.96412 ? 92  ASP B CA  1 
ATOM   2992 C  C   . ASP B 1 92  ? -7.56658  20.36406  13.04391  1.000 67.38723 ? 92  ASP B C   1 
ATOM   2993 O  O   . ASP B 1 92  ? -8.52806  20.17993  13.79843  1.000 66.16042 ? 92  ASP B O   1 
ATOM   2994 C  CB  . ASP B 1 92  ? -6.37017  22.50224  13.56681  1.000 67.49063 ? 92  ASP B CB  1 
ATOM   2995 C  CG  . ASP B 1 92  ? -6.17082  23.08113  12.17429  1.000 74.34563 ? 92  ASP B CG  1 
ATOM   2996 O  OD1 . ASP B 1 92  ? -6.31789  22.33259  11.18243  1.000 78.89791 ? 92  ASP B OD1 1 
ATOM   2997 O  OD2 . ASP B 1 92  ? -5.85656  24.28513  12.07010  1.000 75.21519 ? 92  ASP B OD2 1 
ATOM   2998 N  N   . THR B 1 93  ? -7.60337  20.03462  11.75555  1.000 69.72124 ? 93  THR B N   1 
ATOM   2999 C  CA  . THR B 1 93  ? -8.82842  19.62127  11.08463  1.000 64.71103 ? 93  THR B CA  1 
ATOM   3000 C  C   . THR B 1 93  ? -8.68596  18.20737  10.53962  1.000 57.67709 ? 93  THR B C   1 
ATOM   3001 O  O   . THR B 1 93  ? -7.70008  17.89369  9.86434   1.000 54.21663 ? 93  THR B O   1 
ATOM   3002 C  CB  . THR B 1 93  ? -9.17371  20.58334  9.94439   1.000 63.13511 ? 93  THR B CB  1 
ATOM   3003 O  OG1 . THR B 1 93  ? -9.27506  21.91658  10.45805  1.000 76.44453 ? 93  THR B OG1 1 
ATOM   3004 C  CG2 . THR B 1 93  ? -10.49354 20.19085  9.29486   1.000 64.43777 ? 93  THR B CG2 1 
ATOM   3005 N  N   . ALA B 1 94  ? -9.67579  17.36396  10.82496  1.000 53.28766 ? 94  ALA B N   1 
ATOM   3006 C  CA  . ALA B 1 94  ? -9.74000  16.05005  10.20345  1.000 53.46324 ? 94  ALA B CA  1 
ATOM   3007 C  C   . ALA B 1 94  ? -10.11761 16.18423  8.73303   1.000 56.47438 ? 94  ALA B C   1 
ATOM   3008 O  O   . ALA B 1 94  ? -10.91374 17.04867  8.35567   1.000 52.13639 ? 94  ALA B O   1 
ATOM   3009 C  CB  . ALA B 1 94  ? -10.74961 15.16302  10.92809  1.000 39.61491 ? 94  ALA B CB  1 
ATOM   3010 N  N   . ASN B 1 95  ? -9.53736  15.33094  7.90275   1.000 54.14400 ? 95  ASN B N   1 
ATOM   3011 C  CA  . ASN B 1 95  ? -9.78570  15.37895  6.46547   1.000 49.44204 ? 95  ASN B CA  1 
ATOM   3012 C  C   . ASN B 1 95  ? -11.20348 14.90872  6.16783   1.000 43.96200 ? 95  ASN B C   1 
ATOM   3013 O  O   . ASN B 1 95  ? -11.51437 13.73354  6.40922   1.000 46.76501 ? 95  ASN B O   1 
ATOM   3014 C  CB  . ASN B 1 95  ? -8.76361  14.51464  5.72458   1.000 47.14189 ? 95  ASN B CB  1 
ATOM   3015 C  CG  . ASN B 1 95  ? -8.82850  14.68858  4.21501   1.000 52.03895 ? 95  ASN B CG  1 
ATOM   3016 O  OD1 . ASN B 1 95  ? -9.61591  15.48399  3.69905   1.000 48.07475 ? 95  ASN B OD1 1 
ATOM   3017 N  ND2 . ASN B 1 95  ? -7.98623  13.95223  3.50061   1.000 46.64941 ? 95  ASN B ND2 1 
ATOM   3018 N  N   . PRO B 1 96  ? -12.08687 15.76807  5.65358   1.000 46.61292 ? 96  PRO B N   1 
ATOM   3019 C  CA  . PRO B 1 96  ? -13.46630 15.32880  5.38590   1.000 46.67115 ? 96  PRO B CA  1 
ATOM   3020 C  C   . PRO B 1 96  ? -13.56609 14.25876  4.31480   1.000 48.75072 ? 96  PRO B C   1 
ATOM   3021 O  O   . PRO B 1 96  ? -14.56267 13.52594  4.28456   1.000 44.56399 ? 96  PRO B O   1 
ATOM   3022 C  CB  . PRO B 1 96  ? -14.16834 16.62291  4.95275   1.000 43.30915 ? 96  PRO B CB  1 
ATOM   3023 C  CG  . PRO B 1 96  ? -13.06777 17.49161  4.43526   1.000 46.59200 ? 96  PRO B CG  1 
ATOM   3024 C  CD  . PRO B 1 96  ? -11.87184 17.17845  5.28679   1.000 47.45284 ? 96  PRO B CD  1 
ATOM   3025 N  N   . LYS B 1 97  ? -12.56656 14.13787  3.44099   1.000 43.98444 ? 97  LYS B N   1 
ATOM   3026 C  CA  . LYS B 1 97  ? -12.56189 13.13718  2.38368   1.000 41.95838 ? 97  LYS B CA  1 
ATOM   3027 C  C   . LYS B 1 97  ? -11.77515 11.88733  2.76623   1.000 45.57143 ? 97  LYS B C   1 
ATOM   3028 O  O   . LYS B 1 97  ? -11.29843 11.16794  1.88176   1.000 44.38546 ? 97  LYS B O   1 
ATOM   3029 C  CB  . LYS B 1 97  ? -12.01305 13.74654  1.09213   1.000 38.68094 ? 97  LYS B CB  1 
ATOM   3030 C  CG  . LYS B 1 97  ? -12.91834 14.82240  0.50586   1.000 45.38175 ? 97  LYS B CG  1 
ATOM   3031 C  CD  . LYS B 1 97  ? -12.15130 16.08051  0.12953   1.000 55.68208 ? 97  LYS B CD  1 
ATOM   3032 C  CE  . LYS B 1 97  ? -11.57335 15.99267  -1.27316  1.000 48.17960 ? 97  LYS B CE  1 
ATOM   3033 N  NZ  . LYS B 1 97  ? -11.00686 17.29894  -1.71419  1.000 53.62924 ? 97  LYS B NZ  1 
ATOM   3034 N  N   . THR B 1 98  ? -11.63688 11.61462  4.05834   1.000 39.73273 ? 98  THR B N   1 
ATOM   3035 C  CA  . THR B 1 98  ? -10.92179 10.42586  4.51408   1.000 41.64956 ? 98  THR B CA  1 
ATOM   3036 C  C   . THR B 1 98  ? -11.70694 9.17375   4.14838   1.000 39.18728 ? 98  THR B C   1 
ATOM   3037 O  O   . THR B 1 98  ? -12.85682 9.02640   4.58299   1.000 45.44083 ? 98  THR B O   1 
ATOM   3038 C  CB  . THR B 1 98  ? -10.69587 10.47440  6.02369   1.000 37.08927 ? 98  THR B CB  1 
ATOM   3039 O  OG1 . THR B 1 98  ? -9.80889  11.55139  6.34752   1.000 41.54019 ? 98  THR B OG1 1 
ATOM   3040 C  CG2 . THR B 1 98  ? -10.09088 9.16903   6.50965   1.000 41.88421 ? 98  THR B CG2 1 
ATOM   3041 N  N   . PRO B 1 99  ? -11.14708 8.26163   3.36317   1.000 37.42082 ? 99  PRO B N   1 
ATOM   3042 C  CA  . PRO B 1 99  ? -11.85381 7.02068   3.04205   1.000 37.38122 ? 99  PRO B CA  1 
ATOM   3043 C  C   . PRO B 1 99  ? -11.64807 5.97528   4.12949   1.000 34.52317 ? 99  PRO B C   1 
ATOM   3044 O  O   . PRO B 1 99  ? -10.82270 6.12574   5.03073   1.000 35.55019 ? 99  PRO B O   1 
ATOM   3045 C  CB  . PRO B 1 99  ? -11.19783 6.58487   1.73058   1.000 36.92499 ? 99  PRO B CB  1 
ATOM   3046 C  CG  . PRO B 1 99  ? -9.78489  7.06330   1.87710   1.000 35.85355 ? 99  PRO B CG  1 
ATOM   3047 C  CD  . PRO B 1 99  ? -9.85612  8.35803   2.65913   1.000 32.35497 ? 99  PRO B CD  1 
ATOM   3048 N  N   . LYS B 1 100 ? -12.43014 4.90204   4.03272   1.000 31.88169 ? 100 LYS B N   1 
ATOM   3049 C  CA  . LYS B 1 100 ? -12.12193 3.70213   4.79740   1.000 35.71493 ? 100 LYS B CA  1 
ATOM   3050 C  C   . LYS B 1 100 ? -10.75912 3.18498   4.36471   1.000 34.53700 ? 100 LYS B C   1 
ATOM   3051 O  O   . LYS B 1 100 ? -10.52540 2.95124   3.17545   1.000 34.93351 ? 100 LYS B O   1 
ATOM   3052 C  CB  . LYS B 1 100 ? -13.19397 2.63481   4.58674   1.000 31.89300 ? 100 LYS B CB  1 
ATOM   3053 C  CG  . LYS B 1 100 ? -14.54026 2.96964   5.20449   1.000 53.82797 ? 100 LYS B CG  1 
ATOM   3054 C  CD  . LYS B 1 100 ? -15.52814 1.83228   5.00308   1.000 59.89006 ? 100 LYS B CD  1 
ATOM   3055 C  CE  . LYS B 1 100 ? -16.90540 2.18202   5.54322   1.000 68.08392 ? 100 LYS B CE  1 
ATOM   3056 N  NZ  . LYS B 1 100 ? -17.88977 1.09184   5.28868   1.000 68.92372 ? 100 LYS B NZ  1 
ATOM   3057 N  N   . TYR B 1 101 ? -9.85032  3.02631   5.32227   1.000 40.35328 ? 101 TYR B N   1 
ATOM   3058 C  CA  . TYR B 1 101 ? -8.47606  2.70530   4.97756   1.000 34.86709 ? 101 TYR B CA  1 
ATOM   3059 C  C   . TYR B 1 101 ? -7.85057  1.84782   6.06511   1.000 40.69412 ? 101 TYR B C   1 
ATOM   3060 O  O   . TYR B 1 101 ? -8.35903  1.75397   7.18555   1.000 40.36202 ? 101 TYR B O   1 
ATOM   3061 C  CB  . TYR B 1 101 ? -7.64182  3.97698   4.76861   1.000 32.81791 ? 101 TYR B CB  1 
ATOM   3062 C  CG  . TYR B 1 101 ? -7.17840  4.63159   6.05504   1.000 40.59275 ? 101 TYR B CG  1 
ATOM   3063 C  CD1 . TYR B 1 101 ? -5.93926  4.32599   6.60554   1.000 33.65972 ? 101 TYR B CD1 1 
ATOM   3064 C  CD2 . TYR B 1 101 ? -7.97616  5.55696   6.71634   1.000 41.64542 ? 101 TYR B CD2 1 
ATOM   3065 C  CE1 . TYR B 1 101 ? -5.51116  4.91455   7.77707   1.000 37.37666 ? 101 TYR B CE1 1 
ATOM   3066 C  CE2 . TYR B 1 101 ? -7.55294  6.15456   7.89157   1.000 33.35873 ? 101 TYR B CE2 1 
ATOM   3067 C  CZ  . TYR B 1 101 ? -6.31812  5.82876   8.41545   1.000 44.22851 ? 101 TYR B CZ  1 
ATOM   3068 O  OH  . TYR B 1 101 ? -5.88291  6.41434   9.58176   1.000 43.18096 ? 101 TYR B OH  1 
ATOM   3069 N  N   . LYS B 1 102 ? -6.72589  1.22858   5.71321   1.000 36.03312 ? 102 LYS B N   1 
ATOM   3070 C  CA  . LYS B 1 102 ? -5.85878  0.58510   6.68722   1.000 36.21498 ? 102 LYS B CA  1 
ATOM   3071 C  C   . LYS B 1 102 ? -4.46091  0.47308   6.09419   1.000 37.20796 ? 102 LYS B C   1 
ATOM   3072 O  O   . LYS B 1 102 ? -4.28843  0.42206   4.87217   1.000 34.27998 ? 102 LYS B O   1 
ATOM   3073 C  CB  . LYS B 1 102 ? -6.38582  -0.79339  7.10936   1.000 35.72519 ? 102 LYS B CB  1 
ATOM   3074 C  CG  . LYS B 1 102 ? -6.56722  -1.80099  5.98729   1.000 39.99990 ? 102 LYS B CG  1 
ATOM   3075 C  CD  . LYS B 1 102 ? -7.02792  -3.13853  6.55760   1.000 42.79679 ? 102 LYS B CD  1 
ATOM   3076 C  CE  . LYS B 1 102 ? -7.56857  -4.06412  5.47913   1.000 46.87789 ? 102 LYS B CE  1 
ATOM   3077 N  NZ  . LYS B 1 102 ? -6.52562  -4.48634  4.50812   1.000 49.18265 ? 102 LYS B NZ  1 
ATOM   3078 N  N   . PHE B 1 103 ? -3.46718  0.45336   6.97535   1.000 34.34951 ? 103 PHE B N   1 
ATOM   3079 C  CA  . PHE B 1 103 ? -2.07528  0.30449   6.57432   1.000 30.04172 ? 103 PHE B CA  1 
ATOM   3080 C  C   . PHE B 1 103 ? -1.73664  -1.17954  6.51471   1.000 30.48584 ? 103 PHE B C   1 
ATOM   3081 O  O   . PHE B 1 103 ? -1.94263  -1.90624  7.49198   1.000 33.85304 ? 103 PHE B O   1 
ATOM   3082 C  CB  . PHE B 1 103 ? -1.14593  1.02815   7.54999   1.000 32.34538 ? 103 PHE B CB  1 
ATOM   3083 C  CG  . PHE B 1 103 ? -1.34761  2.52005   7.59940   1.000 34.04901 ? 103 PHE B CG  1 
ATOM   3084 C  CD1 . PHE B 1 103 ? -2.02339  3.18458   6.58505   1.000 34.02670 ? 103 PHE B CD1 1 
ATOM   3085 C  CD2 . PHE B 1 103 ? -0.85025  3.25837   8.66068   1.000 30.15566 ? 103 PHE B CD2 1 
ATOM   3086 C  CE1 . PHE B 1 103 ? -2.20287  4.55979   6.63578   1.000 38.29597 ? 103 PHE B CE1 1 
ATOM   3087 C  CE2 . PHE B 1 103 ? -1.02562  4.63001   8.71553   1.000 30.54664 ? 103 PHE B CE2 1 
ATOM   3088 C  CZ  . PHE B 1 103 ? -1.70216  5.28122   7.70366   1.000 33.47678 ? 103 PHE B CZ  1 
ATOM   3089 N  N   . VAL B 1 104 ? -1.23110  -1.63143  5.36776   1.000 29.24074 ? 104 VAL B N   1 
ATOM   3090 C  CA  . VAL B 1 104 ? -0.80146  -3.01186  5.20471   1.000 34.96455 ? 104 VAL B CA  1 
ATOM   3091 C  C   . VAL B 1 104 ? 0.61447   -3.02032  4.64782   1.000 37.93151 ? 104 VAL B C   1 
ATOM   3092 O  O   . VAL B 1 104 ? 1.07200   -2.06145  4.02165   1.000 38.74306 ? 104 VAL B O   1 
ATOM   3093 C  CB  . VAL B 1 104 ? -1.73913  -3.82429  4.28528   1.000 37.01845 ? 104 VAL B CB  1 
ATOM   3094 C  CG1 . VAL B 1 104 ? -3.18347  -3.71419  4.75740   1.000 33.07171 ? 104 VAL B CG1 1 
ATOM   3095 C  CG2 . VAL B 1 104 ? -1.59605  -3.36562  2.84145   1.000 38.61667 ? 104 VAL B CG2 1 
ATOM   3096 N  N   . ARG B 1 105 ? 1.31155   -4.12352  4.89408   1.000 33.32638 ? 105 ARG B N   1 
ATOM   3097 C  CA  . ARG B 1 105 ? 2.62627   -4.36911  4.32005   1.000 31.39792 ? 105 ARG B CA  1 
ATOM   3098 C  C   . ARG B 1 105 ? 2.50844   -5.49315  3.30399   1.000 32.89752 ? 105 ARG B C   1 
ATOM   3099 O  O   . ARG B 1 105 ? 1.92442   -6.54010  3.59803   1.000 34.75630 ? 105 ARG B O   1 
ATOM   3100 C  CB  . ARG B 1 105 ? 3.65240   -4.72479  5.40052   1.000 29.95890 ? 105 ARG B CB  1 
ATOM   3101 C  CG  . ARG B 1 105 ? 5.07044   -4.89158  4.87079   1.000 28.42449 ? 105 ARG B CG  1 
ATOM   3102 C  CD  . ARG B 1 105 ? 6.09694   -4.85964  5.99461   1.000 30.07219 ? 105 ARG B CD  1 
ATOM   3103 N  NE  . ARG B 1 105 ? 7.46116   -5.01203  5.49802   1.000 32.09922 ? 105 ARG B NE  1 
ATOM   3104 C  CZ  . ARG B 1 105 ? 8.26695   -4.00300  5.19705   1.000 27.97231 ? 105 ARG B CZ  1 
ATOM   3105 N  NH1 . ARG B 1 105 ? 7.87928   -2.74566  5.33129   1.000 25.68665 ? 105 ARG B NH1 1 
ATOM   3106 N  NH2 . ARG B 1 105 ? 9.49275   -4.26199  4.74935   1.000 30.63817 ? 105 ARG B NH2 1 
ATOM   3107 N  N   . ILE B 1 106 ? 3.04868   -5.27023  2.11419   1.000 28.00352 ? 106 ILE B N   1 
ATOM   3108 C  CA  . ILE B 1 106 ? 2.94675   -6.22900  1.03345   1.000 40.42694 ? 106 ILE B CA  1 
ATOM   3109 C  C   . ILE B 1 106 ? 4.25308   -6.99923  0.91641   1.000 38.66569 ? 106 ILE B C   1 
ATOM   3110 O  O   . ILE B 1 106 ? 5.29229   -6.61357  1.45580   1.000 32.51636 ? 106 ILE B O   1 
ATOM   3111 C  CB  . ILE B 1 106 ? 2.59104   -5.55060  -0.30474  1.000 32.80227 ? 106 ILE B CB  1 
ATOM   3112 C  CG1 . ILE B 1 106 ? 3.58604   -4.42765  -0.59085  1.000 32.59573 ? 106 ILE B CG1 1 
ATOM   3113 C  CG2 . ILE B 1 106 ? 1.15920   -5.03917  -0.27617  1.000 36.28831 ? 106 ILE B CG2 1 
ATOM   3114 C  CD1 . ILE B 1 106 ? 3.49664   -3.90171  -1.98314  1.000 38.42008 ? 106 ILE B CD1 1 
ATOM   3115 N  N   . GLN B 1 107 ? 4.19483   -8.10259  0.19870   1.000 40.67663 ? 107 GLN B N   1 
ATOM   3116 C  CA  . GLN B 1 107 ? 5.32289   -8.98091  -0.04074  1.000 43.12229 ? 107 GLN B CA  1 
ATOM   3117 C  C   . GLN B 1 107 ? 5.84585   -8.79183  -1.45578  1.000 35.43817 ? 107 GLN B C   1 
ATOM   3118 O  O   . GLN B 1 107 ? 5.12265   -8.32178  -2.33969  1.000 32.98544 ? 107 GLN B O   1 
ATOM   3119 C  CB  . GLN B 1 107 ? 4.90532   -10.44010 0.17264   1.000 42.56587 ? 107 GLN B CB  1 
ATOM   3120 C  CG  . GLN B 1 107 ? 4.21658   -10.68801 1.50577   1.000 53.41307 ? 107 GLN B CG  1 
ATOM   3121 C  CD  . GLN B 1 107 ? 3.68991   -12.10221 1.63631   1.000 65.93163 ? 107 GLN B CD  1 
ATOM   3122 O  OE1 . GLN B 1 107 ? 2.48526   -12.33941 1.54015   1.000 69.29352 ? 107 GLN B OE1 1 
ATOM   3123 N  NE2 . GLN B 1 107 ? 4.59095   -13.05100 1.86285   1.000 65.13025 ? 107 GLN B NE2 1 
ATOM   3124 N  N   . PRO B 1 108 ? 7.11199   -9.12418  -1.70429  1.000 40.96175 ? 108 PRO B N   1 
ATOM   3125 C  CA  . PRO B 1 108 ? 7.61883   -9.10130  -3.08056  1.000 32.53211 ? 108 PRO B CA  1 
ATOM   3126 C  C   . PRO B 1 108 ? 6.76129   -9.97436  -3.98472  1.000 32.37774 ? 108 PRO B C   1 
ATOM   3127 O  O   . PRO B 1 108 ? 6.29369   -11.04390 -3.58667  1.000 32.78583 ? 108 PRO B O   1 
ATOM   3128 C  CB  . PRO B 1 108 ? 9.04137   -9.65389  -2.94568  1.000 43.58422 ? 108 PRO B CB  1 
ATOM   3129 C  CG  . PRO B 1 108 ? 9.42073   -9.38755  -1.54138  1.000 36.83042 ? 108 PRO B CG  1 
ATOM   3130 C  CD  . PRO B 1 108 ? 8.15783   -9.49568  -0.73609  1.000 38.55460 ? 108 PRO B CD  1 
ATOM   3131 N  N   . GLY B 1 109 ? 6.54491   -9.50087  -5.21065  1.000 35.51672 ? 109 GLY B N   1 
ATOM   3132 C  CA  . GLY B 1 109 ? 5.66328   -10.15705 -6.14523  1.000 34.10553 ? 109 GLY B CA  1 
ATOM   3133 C  C   . GLY B 1 109 ? 4.24457   -9.62910  -6.15779  1.000 33.33532 ? 109 GLY B C   1 
ATOM   3134 O  O   . GLY B 1 109 ? 3.54240   -9.80228  -7.16047  1.000 36.88453 ? 109 GLY B O   1 
ATOM   3135 N  N   . GLN B 1 110 ? 3.79858   -8.99951  -5.07574  1.000 38.21942 ? 110 GLN B N   1 
ATOM   3136 C  CA  . GLN B 1 110 ? 2.47772   -8.39338  -5.05335  1.000 30.95497 ? 110 GLN B CA  1 
ATOM   3137 C  C   . GLN B 1 110 ? 2.51209   -7.03060  -5.73597  1.000 33.46422 ? 110 GLN B C   1 
ATOM   3138 O  O   . GLN B 1 110 ? 3.53011   -6.33108  -5.72671  1.000 27.27014 ? 110 GLN B O   1 
ATOM   3139 C  CB  . GLN B 1 110 ? 1.96979   -8.25720  -3.61747  1.000 28.36273 ? 110 GLN B CB  1 
ATOM   3140 C  CG  . GLN B 1 110 ? 1.65231   -9.58882  -2.95009  1.000 39.35783 ? 110 GLN B CG  1 
ATOM   3141 C  CD  . GLN B 1 110 ? 1.07060   -9.43053  -1.55446  1.000 45.41483 ? 110 GLN B CD  1 
ATOM   3142 O  OE1 . GLN B 1 110 ? 1.58200   -8.66770  -0.73573  1.000 44.46867 ? 110 GLN B OE1 1 
ATOM   3143 N  NE2 . GLN B 1 110 ? -0.00859  -10.15425 -1.27992  1.000 57.31640 ? 110 GLN B NE2 1 
ATOM   3144 N  N   . THR B 1 111 ? 1.38525   -6.66078  -6.33854  1.000 29.72702 ? 111 THR B N   1 
ATOM   3145 C  CA  . THR B 1 111 ? 1.27177   -5.43534  -7.11484  1.000 30.29802 ? 111 THR B CA  1 
ATOM   3146 C  C   . THR B 1 111 ? 0.42780   -4.40562  -6.37408  1.000 32.03091 ? 111 THR B C   1 
ATOM   3147 O  O   . THR B 1 111 ? -0.33099  -4.72986  -5.45628  1.000 33.60115 ? 111 THR B O   1 
ATOM   3148 C  CB  . THR B 1 111 ? 0.66079   -5.70977  -8.49589  1.000 31.16030 ? 111 THR B CB  1 
ATOM   3149 O  OG1 . THR B 1 111 ? -0.62138  -6.33104  -8.34066  1.000 28.36572 ? 111 THR B OG1 1 
ATOM   3150 C  CG2 . THR B 1 111 ? 1.56656   -6.62553  -9.31167  1.000 33.46923 ? 111 THR B CG2 1 
ATOM   3151 N  N   . PHE B 1 112 ? 0.56852   -3.14975  -6.79222  1.000 27.10437 ? 112 PHE B N   1 
ATOM   3152 C  CA  . PHE B 1 112 ? -0.18256  -2.05589  -6.19309  1.000 26.29358 ? 112 PHE B CA  1 
ATOM   3153 C  C   . PHE B 1 112 ? -0.15007  -0.86410  -7.13653  1.000 24.89692 ? 112 PHE B C   1 
ATOM   3154 O  O   . PHE B 1 112 ? 0.69976   -0.77589  -8.02612  1.000 28.42024 ? 112 PHE B O   1 
ATOM   3155 C  CB  . PHE B 1 112 ? 0.36867   -1.67239  -4.81161  1.000 25.05680 ? 112 PHE B CB  1 
ATOM   3156 C  CG  . PHE B 1 112 ? 1.82529   -1.27888  -4.81464  1.000 29.66807 ? 112 PHE B CG  1 
ATOM   3157 C  CD1 . PHE B 1 112 ? 2.81658   -2.24338  -4.86762  1.000 33.24037 ? 112 PHE B CD1 1 
ATOM   3158 C  CD2 . PHE B 1 112 ? 2.20298   0.05302   -4.74198  1.000 32.48885 ? 112 PHE B CD2 1 
ATOM   3159 C  CE1 . PHE B 1 112 ? 4.15511   -1.89192  -4.85948  1.000 32.48742 ? 112 PHE B CE1 1 
ATOM   3160 C  CE2 . PHE B 1 112 ? 3.54294   0.41120   -4.73149  1.000 27.19647 ? 112 PHE B CE2 1 
ATOM   3161 C  CZ  . PHE B 1 112 ? 4.51836   -0.56253  -4.79217  1.000 31.60203 ? 112 PHE B CZ  1 
ATOM   3162 N  N   . SER B 1 113 ? -1.09943  0.04501   -6.93603  1.000 26.80306 ? 113 SER B N   1 
ATOM   3163 C  CA  . SER B 1 113 ? -1.17306  1.27694   -7.70599  1.000 27.03538 ? 113 SER B CA  1 
ATOM   3164 C  C   . SER B 1 113 ? -0.42154  2.38661   -6.98363  1.000 27.29907 ? 113 SER B C   1 
ATOM   3165 O  O   . SER B 1 113 ? -0.41352  2.45501   -5.75371  1.000 30.38716 ? 113 SER B O   1 
ATOM   3166 C  CB  . SER B 1 113 ? -2.62813  1.69814   -7.92774  1.000 31.39286 ? 113 SER B CB  1 
ATOM   3167 O  OG  . SER B 1 113 ? -3.31988  0.77184   -8.74710  1.000 30.07192 ? 113 SER B OG  1 
ATOM   3168 N  N   . VAL B 1 114 ? 0.21158   3.25907   -7.76134  1.000 28.23455 ? 114 VAL B N   1 
ATOM   3169 C  CA  . VAL B 1 114 ? 0.98131   4.38018   -7.23563  1.000 33.86134 ? 114 VAL B CA  1 
ATOM   3170 C  C   . VAL B 1 114 ? 0.40606   5.66737   -7.80454  1.000 33.40676 ? 114 VAL B C   1 
ATOM   3171 O  O   . VAL B 1 114 ? 0.29670   5.81629   -9.02745  1.000 36.70065 ? 114 VAL B O   1 
ATOM   3172 C  CB  . VAL B 1 114 ? 2.47769   4.25957   -7.58031  1.000 37.32509 ? 114 VAL B CB  1 
ATOM   3173 C  CG1 . VAL B 1 114 ? 3.22477   5.51313   -7.15379  1.000 36.28362 ? 114 VAL B CG1 1 
ATOM   3174 C  CG2 . VAL B 1 114 ? 3.07877   3.03550   -6.91530  1.000 38.32250 ? 114 VAL B CG2 1 
ATOM   3175 N  N   . LEU B 1 115 ? 0.04774   6.59520   -6.92130  1.000 33.63514 ? 115 LEU B N   1 
ATOM   3176 C  CA  . LEU B 1 115 ? -0.39592  7.92881   -7.31718  1.000 33.53179 ? 115 LEU B CA  1 
ATOM   3177 C  C   . LEU B 1 115 ? 0.79317   8.87520   -7.17751  1.000 34.78608 ? 115 LEU B C   1 
ATOM   3178 O  O   . LEU B 1 115 ? 1.06113   9.39909   -6.09249  1.000 29.53399 ? 115 LEU B O   1 
ATOM   3179 C  CB  . LEU B 1 115 ? -1.57753  8.38596   -6.46996  1.000 28.09376 ? 115 LEU B CB  1 
ATOM   3180 C  CG  . LEU B 1 115 ? -2.18661  9.72505   -6.88620  1.000 31.16307 ? 115 LEU B CG  1 
ATOM   3181 C  CD1 . LEU B 1 115 ? -2.76421  9.62643   -8.29324  1.000 27.16504 ? 115 LEU B CD1 1 
ATOM   3182 C  CD2 . LEU B 1 115 ? -3.24391  10.18217  -5.88974  1.000 33.87595 ? 115 LEU B CD2 1 
ATOM   3183 N  N   . ALA B 1 116 ? 1.50829   9.08901   -8.27987  1.000 34.45832 ? 116 ALA B N   1 
ATOM   3184 C  CA  . ALA B 1 116 ? 2.64091   10.00452  -8.27501  1.000 37.33053 ? 116 ALA B CA  1 
ATOM   3185 C  C   . ALA B 1 116 ? 2.14769   11.43782  -8.13194  1.000 42.28758 ? 116 ALA B C   1 
ATOM   3186 O  O   . ALA B 1 116 ? 1.27187   11.88309  -8.87978  1.000 40.42796 ? 116 ALA B O   1 
ATOM   3187 C  CB  . ALA B 1 116 ? 3.46051   9.84497   -9.55411  1.000 34.26496 ? 116 ALA B CB  1 
ATOM   3188 N  N   . CYS B 1 117 ? 2.70103   12.15598  -7.16033  1.000 41.54429 ? 117 CYS B N   1 
ATOM   3189 C  CA  . CYS B 1 117 ? 2.29131   13.51875  -6.86711  1.000 43.43605 ? 117 CYS B CA  1 
ATOM   3190 C  C   . CYS B 1 117 ? 3.49019   14.45479  -6.92140  1.000 42.66094 ? 117 CYS B C   1 
ATOM   3191 O  O   . CYS B 1 117 ? 4.64639   14.02771  -6.86008  1.000 43.76843 ? 117 CYS B O   1 
ATOM   3192 C  CB  . CYS B 1 117 ? 1.61984   13.61286  -5.49291  1.000 34.81267 ? 117 CYS B CB  1 
ATOM   3193 S  SG  . CYS B 1 117 ? 0.13499   12.60239  -5.34009  1.000 39.42684 ? 117 CYS B SG  1 
ATOM   3194 N  N   . TYR B 1 118 ? 3.19398   15.74684  -7.04392  1.000 45.52998 ? 118 TYR B N   1 
ATOM   3195 C  CA  . TYR B 1 118 ? 4.22011   16.78400  -7.06149  1.000 47.63412 ? 118 TYR B CA  1 
ATOM   3196 C  C   . TYR B 1 118 ? 3.63834   18.03168  -6.41917  1.000 47.08180 ? 118 TYR B C   1 
ATOM   3197 O  O   . TYR B 1 118 ? 2.62663   18.55796  -6.89479  1.000 51.73739 ? 118 TYR B O   1 
ATOM   3198 C  CB  . TYR B 1 118 ? 4.69559   17.07166  -8.48790  1.000 48.28461 ? 118 TYR B CB  1 
ATOM   3199 C  CG  . TYR B 1 118 ? 5.33992   15.87629  -9.15575  1.000 61.58822 ? 118 TYR B CG  1 
ATOM   3200 C  CD1 . TYR B 1 118 ? 6.68302   15.58172  -8.95376  1.000 60.24203 ? 118 TYR B CD1 1 
ATOM   3201 C  CD2 . TYR B 1 118 ? 4.60183   15.03317  -9.97658  1.000 56.14299 ? 118 TYR B CD2 1 
ATOM   3202 C  CE1 . TYR B 1 118 ? 7.27351   14.48474  -9.55701  1.000 58.21175 ? 118 TYR B CE1 1 
ATOM   3203 C  CE2 . TYR B 1 118 ? 5.18353   13.93408  -10.58210 1.000 45.64638 ? 118 TYR B CE2 1 
ATOM   3204 C  CZ  . TYR B 1 118 ? 6.51835   13.66538  -10.37018 1.000 48.90492 ? 118 TYR B CZ  1 
ATOM   3205 O  OH  . TYR B 1 118 ? 7.09685   12.57307  -10.97412 1.000 59.75628 ? 118 TYR B OH  1 
ATOM   3206 N  N   . ASN B 1 119 ? 4.26979   18.48575  -5.33549  1.000 50.49202 ? 119 ASN B N   1 
ATOM   3207 C  CA  . ASN B 1 119 ? 3.79492   19.63727  -4.56627  1.000 57.54468 ? 119 ASN B CA  1 
ATOM   3208 C  C   . ASN B 1 119 ? 2.36207   19.42434  -4.08259  1.000 52.92882 ? 119 ASN B C   1 
ATOM   3209 O  O   . ASN B 1 119 ? 1.52801   20.33143  -4.11610  1.000 52.06184 ? 119 ASN B O   1 
ATOM   3210 C  CB  . ASN B 1 119 ? 3.91979   20.93015  -5.37589  1.000 60.53327 ? 119 ASN B CB  1 
ATOM   3211 C  CG  . ASN B 1 119 ? 5.36202   21.29027  -5.67450  1.000 62.99156 ? 119 ASN B CG  1 
ATOM   3212 O  OD1 . ASN B 1 119 ? 6.26151   20.45709  -5.55167  1.000 63.86850 ? 119 ASN B OD1 1 
ATOM   3213 N  ND2 . ASN B 1 119 ? 5.59047   22.53814  -6.06737  1.000 65.40495 ? 119 ASN B ND2 1 
ATOM   3214 N  N   . GLY B 1 120 ? 2.07299   18.20168  -3.63382  1.000 47.52381 ? 120 GLY B N   1 
ATOM   3215 C  CA  . GLY B 1 120 ? 0.77430   17.86147  -3.09452  1.000 43.45466 ? 120 GLY B CA  1 
ATOM   3216 C  C   . GLY B 1 120 ? -0.32541  17.64405  -4.11063  1.000 43.71947 ? 120 GLY B C   1 
ATOM   3217 O  O   . GLY B 1 120 ? -1.42374  17.22532  -3.72451  1.000 48.24344 ? 120 GLY B O   1 
ATOM   3218 N  N   . SER B 1 121 ? -0.08046  17.91356  -5.39335  1.000 49.33057 ? 121 SER B N   1 
ATOM   3219 C  CA  . SER B 1 121 ? -1.12814  17.74228  -6.39433  1.000 47.71390 ? 121 SER B CA  1 
ATOM   3220 C  C   . SER B 1 121 ? -0.91247  16.44902  -7.16142  1.000 42.38476 ? 121 SER B C   1 
ATOM   3221 O  O   . SER B 1 121 ? 0.19124   16.22027  -7.67943  1.000 39.91961 ? 121 SER B O   1 
ATOM   3222 C  CB  . SER B 1 121 ? -1.14760  18.92334  -7.36157  1.000 40.13628 ? 121 SER B CB  1 
ATOM   3223 O  OG  . SER B 1 121 ? 0.15769   19.22231  -7.82091  1.000 53.98806 ? 121 SER B OG  1 
ATOM   3224 N  N   . PRO B 1 122 ? -1.92098  15.58244  -7.23922  1.000 45.19753 ? 122 PRO B N   1 
ATOM   3225 C  CA  . PRO B 1 122 ? -1.76187  14.32744  -7.98478  1.000 35.94814 ? 122 PRO B CA  1 
ATOM   3226 C  C   . PRO B 1 122 ? -1.49304  14.59199  -9.45845  1.000 41.74993 ? 122 PRO B C   1 
ATOM   3227 O  O   . PRO B 1 122 ? -2.17696  15.39213  -10.09969 1.000 47.50930 ? 122 PRO B O   1 
ATOM   3228 C  CB  . PRO B 1 122 ? -3.10356  13.61718  -7.77073  1.000 36.59775 ? 122 PRO B CB  1 
ATOM   3229 C  CG  . PRO B 1 122 ? -3.65399  14.21501  -6.51915  1.000 38.39569 ? 122 PRO B CG  1 
ATOM   3230 C  CD  . PRO B 1 122 ? -3.21167  15.64702  -6.53348  1.000 36.79956 ? 122 PRO B CD  1 
ATOM   3231 N  N   . SER B 1 123 ? -0.48443  13.90838  -9.99155  1.000 34.64523 ? 123 SER B N   1 
ATOM   3232 C  CA  . SER B 1 123 ? -0.05530  14.07700  -11.37379 1.000 35.74161 ? 123 SER B CA  1 
ATOM   3233 C  C   . SER B 1 123 ? -0.37926  12.88568  -12.26012 1.000 32.91436 ? 123 SER B C   1 
ATOM   3234 O  O   . SER B 1 123 ? -0.79483  13.07255  -13.40507 1.000 36.40488 ? 123 SER B O   1 
ATOM   3235 C  CB  . SER B 1 123 ? 1.45311   14.34661  -11.42482 1.000 38.19446 ? 123 SER B CB  1 
ATOM   3236 O  OG  . SER B 1 123 ? 1.92112   14.37622  -12.76169 1.000 54.33574 ? 123 SER B OG  1 
ATOM   3237 N  N   . GLY B 1 124 ? -0.19467  11.66545  -11.76636 1.000 35.26301 ? 124 GLY B N   1 
ATOM   3238 C  CA  . GLY B 1 124 ? -0.47604  10.48472  -12.55924 1.000 34.79332 ? 124 GLY B CA  1 
ATOM   3239 C  C   . GLY B 1 124 ? -0.57759  9.25895   -11.68372 1.000 35.48330 ? 124 GLY B C   1 
ATOM   3240 O  O   . GLY B 1 124 ? -0.16511  9.26467   -10.52007 1.000 37.55992 ? 124 GLY B O   1 
ATOM   3241 N  N   . VAL B 1 125 ? -1.13930  8.20020   -12.25928 1.000 33.83302 ? 125 VAL B N   1 
ATOM   3242 C  CA  . VAL B 1 125 ? -1.31814  6.92583   -11.57613 1.000 32.27995 ? 125 VAL B CA  1 
ATOM   3243 C  C   . VAL B 1 125 ? -0.76663  5.82455   -12.47072 1.000 38.05794 ? 125 VAL B C   1 
ATOM   3244 O  O   . VAL B 1 125 ? -0.87526  5.89927   -13.70024 1.000 38.11810 ? 125 VAL B O   1 
ATOM   3245 C  CB  . VAL B 1 125 ? -2.80240  6.66850   -11.22396 1.000 32.92063 ? 125 VAL B CB  1 
ATOM   3246 C  CG1 . VAL B 1 125 ? -3.66172  6.61330   -12.47938 1.000 31.74708 ? 125 VAL B CG1 1 
ATOM   3247 C  CG2 . VAL B 1 125 ? -2.95566  5.39248   -10.41075 1.000 31.84013 ? 125 VAL B CG2 1 
ATOM   3248 N  N   . TYR B 1 126 ? -0.15016  4.81475   -11.85767 1.000 33.99295 ? 126 TYR B N   1 
ATOM   3249 C  CA  . TYR B 1 126 ? 0.35814   3.68244   -12.61689 1.000 32.67125 ? 126 TYR B CA  1 
ATOM   3250 C  C   . TYR B 1 126 ? 0.42778   2.45828   -11.71722 1.000 31.34099 ? 126 TYR B C   1 
ATOM   3251 O  O   . TYR B 1 126 ? 0.43796   2.56147   -10.48844 1.000 32.77083 ? 126 TYR B O   1 
ATOM   3252 C  CB  . TYR B 1 126 ? 1.73080   3.98130   -13.23761 1.000 36.59985 ? 126 TYR B CB  1 
ATOM   3253 C  CG  . TYR B 1 126 ? 2.83182   4.28129   -12.24374 1.000 39.03194 ? 126 TYR B CG  1 
ATOM   3254 C  CD1 . TYR B 1 126 ? 3.60079   3.26015   -11.69878 1.000 45.66061 ? 126 TYR B CD1 1 
ATOM   3255 C  CD2 . TYR B 1 126 ? 3.11581   5.58736   -11.86419 1.000 42.94884 ? 126 TYR B CD2 1 
ATOM   3256 C  CE1 . TYR B 1 126 ? 4.61508   3.52924   -10.79351 1.000 46.44544 ? 126 TYR B CE1 1 
ATOM   3257 C  CE2 . TYR B 1 126 ? 4.12848   5.86640   -10.96017 1.000 46.21713 ? 126 TYR B CE2 1 
ATOM   3258 C  CZ  . TYR B 1 126 ? 4.87380   4.83289   -10.42919 1.000 47.86654 ? 126 TYR B CZ  1 
ATOM   3259 O  OH  . TYR B 1 126 ? 5.88181   5.10320   -9.53313  1.000 49.47785 ? 126 TYR B OH  1 
ATOM   3260 N  N   . GLN B 1 127 ? 0.47456   1.29378   -12.35376 1.000 31.98724 ? 127 GLN B N   1 
ATOM   3261 C  CA  . GLN B 1 127 ? 0.52183   0.01338   -11.66533 1.000 31.19662 ? 127 GLN B CA  1 
ATOM   3262 C  C   . GLN B 1 127 ? 1.93876   -0.54229  -11.70984 1.000 35.64345 ? 127 GLN B C   1 
ATOM   3263 O  O   . GLN B 1 127 ? 2.60656   -0.48633  -12.74639 1.000 37.92774 ? 127 GLN B O   1 
ATOM   3264 C  CB  . GLN B 1 127 ? -0.45375  -0.97917  -12.30407 1.000 33.89373 ? 127 GLN B CB  1 
ATOM   3265 C  CG  . GLN B 1 127 ? -0.56291  -2.31074  -11.58389 1.000 30.57168 ? 127 GLN B CG  1 
ATOM   3266 C  CD  . GLN B 1 127 ? -1.50535  -2.26213  -10.39788 1.000 32.68683 ? 127 GLN B CD  1 
ATOM   3267 O  OE1 . GLN B 1 127 ? -1.99575  -1.19652  -10.01819 1.000 28.95126 ? 127 GLN B OE1 1 
ATOM   3268 N  NE2 . GLN B 1 127 ? -1.77048  -3.42309  -9.80804  1.000 36.55341 ? 127 GLN B NE2 1 
ATOM   3269 N  N   . CYS B 1 128 ? 2.39391   -1.07900  -10.58095 1.000 37.53635 ? 128 CYS B N   1 
ATOM   3270 C  CA  . CYS B 1 128 ? 3.73334   -1.63931  -10.48893 1.000 40.67308 ? 128 CYS B CA  1 
ATOM   3271 C  C   . CYS B 1 128 ? 3.70928   -2.80489  -9.51013  1.000 33.94555 ? 128 CYS B C   1 
ATOM   3272 O  O   . CYS B 1 128 ? 2.68195   -3.11060  -8.90046  1.000 38.00312 ? 128 CYS B O   1 
ATOM   3273 C  CB  . CYS B 1 128 ? 4.74711   -0.57570  -10.06057 1.000 39.64134 ? 128 CYS B CB  1 
ATOM   3274 S  SG  . CYS B 1 128 ? 4.48247   0.03710   -8.38698  1.000 44.45305 ? 128 CYS B SG  1 
ATOM   3275 N  N   . ALA B 1 129 ? 4.85742   -3.45688  -9.36262  1.000 33.29022 ? 129 ALA B N   1 
ATOM   3276 C  CA  . ALA B 1 129 ? 5.01346   -4.56759  -8.43904  1.000 37.23654 ? 129 ALA B CA  1 
ATOM   3277 C  C   . ALA B 1 129 ? 6.18632   -4.30923  -7.50237  1.000 39.01706 ? 129 ALA B C   1 
ATOM   3278 O  O   . ALA B 1 129 ? 7.15129   -3.62498  -7.85687  1.000 40.70330 ? 129 ALA B O   1 
ATOM   3279 C  CB  . ALA B 1 129 ? 5.22939   -5.88842  -9.18621  1.000 35.33383 ? 129 ALA B CB  1 
ATOM   3280 N  N   . MET B 1 130 ? 6.08617   -4.85377  -6.29428  1.000 39.58323 ? 130 MET B N   1 
ATOM   3281 C  CA  . MET B 1 130 ? 7.21902   -4.89150  -5.37829  1.000 33.85563 ? 130 MET B CA  1 
ATOM   3282 C  C   . MET B 1 130 ? 8.21051   -5.93179  -5.88381  1.000 35.73819 ? 130 MET B C   1 
ATOM   3283 O  O   . MET B 1 130 ? 7.92412   -7.13257  -5.85231  1.000 37.14727 ? 130 MET B O   1 
ATOM   3284 C  CB  . MET B 1 130 ? 6.73727   -5.21826  -3.96765  1.000 31.68908 ? 130 MET B CB  1 
ATOM   3285 C  CG  . MET B 1 130 ? 7.84407   -5.37213  -2.93149  1.000 36.49325 ? 130 MET B CG  1 
ATOM   3286 S  SD  . MET B 1 130 ? 8.69157   -3.82504  -2.56036  1.000 42.84866 ? 130 MET B SD  1 
ATOM   3287 C  CE  . MET B 1 130 ? 7.33245   -2.82659  -1.95722  1.000 31.29202 ? 130 MET B CE  1 
ATOM   3288 N  N   . ARG B 1 131 ? 9.36797   -5.47565  -6.37565  1.000 38.12724 ? 131 ARG B N   1 
ATOM   3289 C  CA  . ARG B 1 131 ? 10.34666  -6.38750  -6.95013  1.000 35.67734 ? 131 ARG B CA  1 
ATOM   3290 C  C   . ARG B 1 131 ? 10.86407  -7.35511  -5.88748  1.000 36.05694 ? 131 ARG B C   1 
ATOM   3291 O  O   . ARG B 1 131 ? 10.78916  -7.07777  -4.68662  1.000 31.84301 ? 131 ARG B O   1 
ATOM   3292 C  CB  . ARG B 1 131 ? 11.52176  -5.61818  -7.55849  1.000 34.16275 ? 131 ARG B CB  1 
ATOM   3293 C  CG  . ARG B 1 131 ? 11.15940  -4.60708  -8.64301  1.000 41.47890 ? 131 ARG B CG  1 
ATOM   3294 C  CD  . ARG B 1 131 ? 10.37433  -5.24056  -9.77035  1.000 41.72263 ? 131 ARG B CD  1 
ATOM   3295 N  NE  . ARG B 1 131 ? 10.99727  -6.46404  -10.25835 1.000 36.81572 ? 131 ARG B NE  1 
ATOM   3296 C  CZ  . ARG B 1 131 ? 10.44098  -7.28187  -11.14120 1.000 39.88240 ? 131 ARG B CZ  1 
ATOM   3297 N  NH1 . ARG B 1 131 ? 9.25664   -7.02267  -11.67439 1.000 35.08390 ? 131 ARG B NH1 1 
ATOM   3298 N  NH2 . ARG B 1 131 ? 11.08539  -8.38992  -11.49461 1.000 29.16525 ? 131 ARG B NH2 1 
ATOM   3299 N  N   . PRO B 1 132 ? 11.37476  -8.51418  -6.31061  1.000 38.84787 ? 132 PRO B N   1 
ATOM   3300 C  CA  . PRO B 1 132 ? 12.02395  -9.41580  -5.34604  1.000 38.58007 ? 132 PRO B CA  1 
ATOM   3301 C  C   . PRO B 1 132 ? 13.16782  -8.77060  -4.58036  1.000 37.47105 ? 132 PRO B C   1 
ATOM   3302 O  O   . PRO B 1 132 ? 13.40035  -9.13460  -3.42124  1.000 32.31959 ? 132 PRO B O   1 
ATOM   3303 C  CB  . PRO B 1 132 ? 12.50774  -10.57029 -6.22964  1.000 34.54241 ? 132 PRO B CB  1 
ATOM   3304 C  CG  . PRO B 1 132 ? 11.50334  -10.61149 -7.34159  1.000 35.33912 ? 132 PRO B CG  1 
ATOM   3305 C  CD  . PRO B 1 132 ? 11.13688  -9.17163  -7.60854  1.000 29.55373 ? 132 PRO B CD  1 
ATOM   3306 N  N   . ASN B 1 133 ? 13.88693  -7.81723  -5.17579  1.000 33.46107 ? 133 ASN B N   1 
ATOM   3307 C  CA  . ASN B 1 133 ? 14.90667  -7.07646  -4.44487  1.000 30.12708 ? 133 ASN B CA  1 
ATOM   3308 C  C   . ASN B 1 133 ? 14.32773  -5.89314  -3.68442  1.000 40.31006 ? 133 ASN B C   1 
ATOM   3309 O  O   . ASN B 1 133 ? 15.07976  -4.99399  -3.28907  1.000 38.76329 ? 133 ASN B O   1 
ATOM   3310 C  CB  . ASN B 1 133 ? 16.02926  -6.61685  -5.38479  1.000 31.67282 ? 133 ASN B CB  1 
ATOM   3311 C  CG  . ASN B 1 133 ? 15.59617  -5.53924  -6.37256  1.000 37.51661 ? 133 ASN B CG  1 
ATOM   3312 O  OD1 . ASN B 1 133 ? 14.45340  -5.08077  -6.37868  1.000 36.68365 ? 133 ASN B OD1 1 
ATOM   3313 N  ND2 . ASN B 1 133 ? 16.53360  -5.12340  -7.21567  1.000 39.16196 ? 133 ASN B ND2 1 
ATOM   3314 N  N   . PHE B 1 134 ? 13.00579  -5.86305  -3.51074  1.000 34.18923 ? 134 PHE B N   1 
ATOM   3315 C  CA  . PHE B 1 134 ? 12.30301  -4.87973  -2.69166  1.000 35.60256 ? 134 PHE B CA  1 
ATOM   3316 C  C   . PHE B 1 134 ? 12.37359  -3.46723  -3.25427  1.000 32.36146 ? 134 PHE B C   1 
ATOM   3317 O  O   . PHE B 1 134 ? 12.07370  -2.50256  -2.54520  1.000 41.72311 ? 134 PHE B O   1 
ATOM   3318 C  CB  . PHE B 1 134 ? 12.81964  -4.88184  -1.25334  1.000 33.59344 ? 134 PHE B CB  1 
ATOM   3319 C  CG  . PHE B 1 134 ? 12.41160  -6.08612  -0.46061  1.000 37.19581 ? 134 PHE B CG  1 
ATOM   3320 C  CD1 . PHE B 1 134 ? 11.12637  -6.18607  0.04173   1.000 37.76502 ? 134 PHE B CD1 1 
ATOM   3321 C  CD2 . PHE B 1 134 ? 13.31362  -7.10737  -0.19697  1.000 32.97341 ? 134 PHE B CD2 1 
ATOM   3322 C  CE1 . PHE B 1 134 ? 10.73848  -7.28749  0.78415   1.000 40.02407 ? 134 PHE B CE1 1 
ATOM   3323 C  CE2 . PHE B 1 134 ? 12.93251  -8.21507  0.54360   1.000 36.26659 ? 134 PHE B CE2 1 
ATOM   3324 C  CZ  . PHE B 1 134 ? 11.64167  -8.30519  1.03496   1.000 39.69018 ? 134 PHE B CZ  1 
ATOM   3325 N  N   . THR B 1 135 ? 12.78201  -3.30872  -4.50272  1.000 33.06521 ? 135 THR B N   1 
ATOM   3326 C  CA  . THR B 1 135 ? 12.62097  -2.02501  -5.16219  1.000 35.86352 ? 135 THR B CA  1 
ATOM   3327 C  C   . THR B 1 135 ? 11.32012  -2.02481  -5.95852  1.000 39.43159 ? 135 THR B C   1 
ATOM   3328 O  O   . THR B 1 135 ? 10.60512  -3.02603  -6.03154  1.000 35.26146 ? 135 THR B O   1 
ATOM   3329 C  CB  . THR B 1 135 ? 13.81166  -1.72286  -6.07479  1.000 38.70239 ? 135 THR B CB  1 
ATOM   3330 O  OG1 . THR B 1 135 ? 13.87125  -2.69219  -7.12865  1.000 38.24266 ? 135 THR B OG1 1 
ATOM   3331 C  CG2 . THR B 1 135 ? 15.10668  -1.76532  -5.28238  1.000 34.31820 ? 135 THR B CG2 1 
ATOM   3332 N  N   . ILE B 1 136 ? 10.99383  -0.87143  -6.53025  1.000 34.52501 ? 136 ILE B N   1 
ATOM   3333 C  CA  . ILE B 1 136 ? 9.94424   -0.77080  -7.53331  1.000 37.81256 ? 136 ILE B CA  1 
ATOM   3334 C  C   . ILE B 1 136 ? 10.50108  0.03412   -8.69622  1.000 46.71595 ? 136 ILE B C   1 
ATOM   3335 O  O   . ILE B 1 136 ? 11.25809  0.99228   -8.50000  1.000 43.40724 ? 136 ILE B O   1 
ATOM   3336 C  CB  . ILE B 1 136 ? 8.64054   -0.13729  -6.98940  1.000 38.26287 ? 136 ILE B CB  1 
ATOM   3337 C  CG1 . ILE B 1 136 ? 8.80940   1.35718   -6.71949  1.000 37.51395 ? 136 ILE B CG1 1 
ATOM   3338 C  CG2 . ILE B 1 136 ? 8.16338   -0.85428  -5.72722  1.000 37.76279 ? 136 ILE B CG2 1 
ATOM   3339 C  CD1 . ILE B 1 136 ? 7.52377   2.04184   -6.31053  1.000 41.36792 ? 136 ILE B CD1 1 
ATOM   3340 N  N   . LYS B 1 137 ? 10.16483  -0.38773  -9.91192  1.000 42.02519 ? 137 LYS B N   1 
ATOM   3341 C  CA  . LYS B 1 137 ? 10.58349  0.32546   -11.11321 1.000 42.48347 ? 137 LYS B CA  1 
ATOM   3342 C  C   . LYS B 1 137 ? 9.48064   1.32188   -11.44963 1.000 39.58687 ? 137 LYS B C   1 
ATOM   3343 O  O   . LYS B 1 137 ? 8.58309   1.06576   -12.25055 1.000 45.32485 ? 137 LYS B O   1 
ATOM   3344 C  CB  . LYS B 1 137 ? 10.86092  -0.65313  -12.24743 1.000 44.51061 ? 137 LYS B CB  1 
ATOM   3345 C  CG  . LYS B 1 137 ? 11.92357  -1.69351  -11.90246 1.000 49.60409 ? 137 LYS B CG  1 
ATOM   3346 C  CD  . LYS B 1 137 ? 12.44201  -2.39994  -13.14668 1.000 57.99220 ? 137 LYS B CD  1 
ATOM   3347 C  CE  . LYS B 1 137 ? 11.71723  -3.71257  -13.40638 1.000 53.64075 ? 137 LYS B CE  1 
ATOM   3348 N  NZ  . LYS B 1 137 ? 12.49535  -4.88238  -12.90508 1.000 53.43186 ? 137 LYS B NZ  1 
ATOM   3349 N  N   . GLY B 1 138 ? 9.53956   2.47798   -10.78758 1.000 39.46375 ? 138 GLY B N   1 
ATOM   3350 C  CA  . GLY B 1 138 ? 8.52892   3.49948   -10.92699 1.000 48.47280 ? 138 GLY B CA  1 
ATOM   3351 C  C   . GLY B 1 138 ? 8.97007   4.64501   -11.82599 1.000 49.22664 ? 138 GLY B C   1 
ATOM   3352 O  O   . GLY B 1 138 ? 10.06028  4.65915   -12.39114 1.000 55.51878 ? 138 GLY B O   1 
ATOM   3353 N  N   . SER B 1 139 ? 8.07897   5.62302   -11.95057 1.000 56.11427 ? 139 SER B N   1 
ATOM   3354 C  CA  . SER B 1 139 ? 8.32077   6.82323   -12.74645 1.000 61.70353 ? 139 SER B CA  1 
ATOM   3355 C  C   . SER B 1 139 ? 8.15042   8.02014   -11.81925 1.000 59.77257 ? 139 SER B C   1 
ATOM   3356 O  O   . SER B 1 139 ? 7.02411   8.43010   -11.52040 1.000 60.08160 ? 139 SER B O   1 
ATOM   3357 C  CB  . SER B 1 139 ? 7.37625   6.89327   -13.94347 1.000 66.29266 ? 139 SER B CB  1 
ATOM   3358 O  OG  . SER B 1 139 ? 7.79938   7.88133   -14.86728 1.000 70.42361 ? 139 SER B OG  1 
ATOM   3359 N  N   . PHE B 1 140 ? 9.27157   8.57393   -11.36520 1.000 63.96825 ? 140 PHE B N   1 
ATOM   3360 C  CA  . PHE B 1 140 ? 9.26761   9.66996   -10.40776 1.000 66.95776 ? 140 PHE B CA  1 
ATOM   3361 C  C   . PHE B 1 140 ? 10.24813  10.74398  -10.85011 1.000 79.17503 ? 140 PHE B C   1 
ATOM   3362 O  O   . PHE B 1 140 ? 11.38156  10.43682  -11.23241 1.000 80.08172 ? 140 PHE B O   1 
ATOM   3363 C  CB  . PHE B 1 140 ? 9.63568   9.17378   -9.00566  1.000 59.38905 ? 140 PHE B CB  1 
ATOM   3364 C  CG  . PHE B 1 140 ? 8.56014   8.35644   -8.34586  1.000 56.02318 ? 140 PHE B CG  1 
ATOM   3365 C  CD1 . PHE B 1 140 ? 7.23862   8.77185   -8.36726  1.000 52.96845 ? 140 PHE B CD1 1 
ATOM   3366 C  CD2 . PHE B 1 140 ? 8.87190   7.17034   -7.70590  1.000 49.76555 ? 140 PHE B CD2 1 
ATOM   3367 C  CE1 . PHE B 1 140 ? 6.25244   8.02216   -7.75763  1.000 46.23086 ? 140 PHE B CE1 1 
ATOM   3368 C  CE2 . PHE B 1 140 ? 7.88918   6.41441   -7.09532  1.000 52.47861 ? 140 PHE B CE2 1 
ATOM   3369 C  CZ  . PHE B 1 140 ? 6.57840   6.84222   -7.11980  1.000 49.92688 ? 140 PHE B CZ  1 
ATOM   3370 N  N   . LEU B 1 141 ? 9.80777   11.99641  -10.79654 1.000 75.20011 ? 141 LEU B N   1 
ATOM   3371 C  CA  . LEU B 1 141 ? 10.66271  13.15204  -11.00318 1.000 75.39020 ? 141 LEU B CA  1 
ATOM   3372 C  C   . LEU B 1 141 ? 10.94867  13.80619  -9.65178  1.000 74.11000 ? 141 LEU B C   1 
ATOM   3373 O  O   . LEU B 1 141 ? 10.62628  13.25770  -8.59039  1.000 69.08097 ? 141 LEU B O   1 
ATOM   3374 C  CB  . LEU B 1 141 ? 10.01004  14.12570  -11.98777 1.000 69.65829 ? 141 LEU B CB  1 
ATOM   3375 N  N   . ASN B 1 142 ? 11.56186  14.98579  -9.69010  1.000 75.84742 ? 142 ASN B N   1 
ATOM   3376 C  CA  . ASN B 1 142 ? 11.83482  15.71955  -8.46311  1.000 71.44080 ? 142 ASN B CA  1 
ATOM   3377 C  C   . ASN B 1 142 ? 10.53059  16.16492  -7.81108  1.000 67.91643 ? 142 ASN B C   1 
ATOM   3378 O  O   . ASN B 1 142 ? 9.61891   16.65993  -8.48039  1.000 64.35267 ? 142 ASN B O   1 
ATOM   3379 C  CB  . ASN B 1 142 ? 12.72130  16.92993  -8.75412  1.000 67.05228 ? 142 ASN B CB  1 
ATOM   3380 N  N   . GLY B 1 143 ? 10.44222  15.97738  -6.49482  1.000 60.28034 ? 143 GLY B N   1 
ATOM   3381 C  CA  . GLY B 1 143 ? 9.27888   16.37999  -5.73209  1.000 59.97060 ? 143 GLY B CA  1 
ATOM   3382 C  C   . GLY B 1 143 ? 8.24406   15.30081  -5.50425  1.000 39.04204 ? 143 GLY B C   1 
ATOM   3383 O  O   . GLY B 1 143 ? 7.22436   15.57472  -4.86102  1.000 48.03821 ? 143 GLY B O   1 
ATOM   3384 N  N   . SER B 1 144 ? 8.47162   14.08559  -6.00120  1.000 47.42289 ? 144 SER B N   1 
ATOM   3385 C  CA  . SER B 1 144 ? 7.50250   13.00893  -5.84892  1.000 46.67578 ? 144 SER B CA  1 
ATOM   3386 C  C   . SER B 1 144 ? 7.58862   12.30806  -4.50039  1.000 45.84883 ? 144 SER B C   1 
ATOM   3387 O  O   . SER B 1 144 ? 6.72057   11.47884  -4.20376  1.000 36.99403 ? 144 SER B O   1 
ATOM   3388 C  CB  . SER B 1 144 ? 7.68178   11.97939  -6.96476  1.000 50.52465 ? 144 SER B CB  1 
ATOM   3389 O  OG  . SER B 1 144 ? 8.95161   11.35932  -6.87797  1.000 51.58828 ? 144 SER B OG  1 
ATOM   3390 N  N   . CYS B 1 145 ? 8.60742   12.60760  -3.69310  1.000 39.15158 ? 145 CYS B N   1 
ATOM   3391 C  CA  . CYS B 1 145 ? 8.73434   12.00322  -2.37227  1.000 38.51053 ? 145 CYS B CA  1 
ATOM   3392 C  C   . CYS B 1 145 ? 7.46664   12.22660  -1.56411  1.000 33.22929 ? 145 CYS B C   1 
ATOM   3393 O  O   . CYS B 1 145 ? 6.95230   13.34474  -1.49076  1.000 41.82520 ? 145 CYS B O   1 
ATOM   3394 C  CB  . CYS B 1 145 ? 9.93974   12.59043  -1.63416  1.000 38.39884 ? 145 CYS B CB  1 
ATOM   3395 S  SG  . CYS B 1 145 ? 11.53252  12.18140  -2.36295  1.000 50.07259 ? 145 CYS B SG  1 
ATOM   3396 N  N   . GLY B 1 146 ? 6.95888   11.15260  -0.96508  1.000 35.58772 ? 146 GLY B N   1 
ATOM   3397 C  CA  . GLY B 1 146 ? 5.69132   11.19698  -0.26867  1.000 34.82299 ? 146 GLY B CA  1 
ATOM   3398 C  C   . GLY B 1 146 ? 4.51415   10.63917  -1.04023  1.000 35.39125 ? 146 GLY B C   1 
ATOM   3399 O  O   . GLY B 1 146 ? 3.41487   10.55335  -0.47811  1.000 34.55875 ? 146 GLY B O   1 
ATOM   3400 N  N   . SER B 1 147 ? 4.69956   10.27344  -2.30705  1.000 35.20022 ? 147 SER B N   1 
ATOM   3401 C  CA  . SER B 1 147 ? 3.65447   9.57812   -3.04389  1.000 32.66618 ? 147 SER B CA  1 
ATOM   3402 C  C   . SER B 1 147 ? 3.43831   8.19046   -2.45083  1.000 32.65219 ? 147 SER B C   1 
ATOM   3403 O  O   . SER B 1 147 ? 4.36894   7.55335   -1.95060  1.000 34.66789 ? 147 SER B O   1 
ATOM   3404 C  CB  . SER B 1 147 ? 4.02082   9.47041   -4.52327  1.000 28.12465 ? 147 SER B CB  1 
ATOM   3405 O  OG  . SER B 1 147 ? 4.23302   10.75249  -5.09004  1.000 36.54189 ? 147 SER B OG  1 
ATOM   3406 N  N   . VAL B 1 148 ? 2.19532   7.72063   -2.50488  1.000 29.85040 ? 148 VAL B N   1 
ATOM   3407 C  CA  . VAL B 1 148 ? 1.82546   6.48646   -1.82585  1.000 31.41536 ? 148 VAL B CA  1 
ATOM   3408 C  C   . VAL B 1 148 ? 1.41032   5.43024   -2.83966  1.000 33.37875 ? 148 VAL B C   1 
ATOM   3409 O  O   . VAL B 1 148 ? 0.93939   5.73548   -3.94060  1.000 36.03012 ? 148 VAL B O   1 
ATOM   3410 C  CB  . VAL B 1 148 ? 0.70106   6.71457   -0.79080  1.000 29.75425 ? 148 VAL B CB  1 
ATOM   3411 C  CG1 . VAL B 1 148 ? 1.22205   7.52029   0.38935   1.000 37.86727 ? 148 VAL B CG1 1 
ATOM   3412 C  CG2 . VAL B 1 148 ? -0.47840  7.41502   -1.43633  1.000 32.34552 ? 148 VAL B CG2 1 
ATOM   3413 N  N   . GLY B 1 149 ? 1.60510   4.17185   -2.45274  1.000 33.60044 ? 149 GLY B N   1 
ATOM   3414 C  CA  . GLY B 1 149 ? 1.09099   3.03235   -3.18679  1.000 28.22471 ? 149 GLY B CA  1 
ATOM   3415 C  C   . GLY B 1 149 ? -0.06665  2.42184   -2.42087  1.000 33.32642 ? 149 GLY B C   1 
ATOM   3416 O  O   . GLY B 1 149 ? -0.10297  2.47090   -1.18874  1.000 35.20130 ? 149 GLY B O   1 
ATOM   3417 N  N   . PHE B 1 150 ? -1.01584  1.83889   -3.15000  1.000 29.18427 ? 150 PHE B N   1 
ATOM   3418 C  CA  . PHE B 1 150 ? -2.25462  1.41507   -2.51318  1.000 34.01372 ? 150 PHE B CA  1 
ATOM   3419 C  C   . PHE B 1 150 ? -2.94341  0.34770   -3.34987  1.000 30.95351 ? 150 PHE B C   1 
ATOM   3420 O  O   . PHE B 1 150 ? -2.71634  0.22831   -4.55666  1.000 30.36222 ? 150 PHE B O   1 
ATOM   3421 C  CB  . PHE B 1 150 ? -3.19987  2.60313   -2.30990  1.000 27.91247 ? 150 PHE B CB  1 
ATOM   3422 C  CG  . PHE B 1 150 ? -3.68646  3.21144   -3.59812  1.000 31.25286 ? 150 PHE B CG  1 
ATOM   3423 C  CD1 . PHE B 1 150 ? -2.91478  4.13952   -4.28141  1.000 31.50979 ? 150 PHE B CD1 1 
ATOM   3424 C  CD2 . PHE B 1 150 ? -4.91308  2.85110   -4.12742  1.000 30.42779 ? 150 PHE B CD2 1 
ATOM   3425 C  CE1 . PHE B 1 150 ? -3.36091  4.69693   -5.46605  1.000 32.66102 ? 150 PHE B CE1 1 
ATOM   3426 C  CE2 . PHE B 1 150 ? -5.36285  3.40421   -5.31183  1.000 29.27099 ? 150 PHE B CE2 1 
ATOM   3427 C  CZ  . PHE B 1 150 ? -4.58804  4.32759   -5.98026  1.000 28.13331 ? 150 PHE B CZ  1 
ATOM   3428 N  N   . ASN B 1 151 ? -3.80079  -0.42038  -2.68001  1.000 30.14960 ? 151 ASN B N   1 
ATOM   3429 C  CA  . ASN B 1 151 ? -4.78689  -1.27400  -3.32469  1.000 31.63323 ? 151 ASN B CA  1 
ATOM   3430 C  C   . ASN B 1 151 ? -6.15995  -0.92842  -2.76475  1.000 35.27459 ? 151 ASN B C   1 
ATOM   3431 O  O   . ASN B 1 151 ? -6.28029  -0.31443  -1.70080  1.000 35.81328 ? 151 ASN B O   1 
ATOM   3432 C  CB  . ASN B 1 151 ? -4.49029  -2.76441  -3.11274  1.000 25.95178 ? 151 ASN B CB  1 
ATOM   3433 C  CG  . ASN B 1 151 ? -3.25063  -3.22373  -3.85454  1.000 32.69294 ? 151 ASN B CG  1 
ATOM   3434 O  OD1 . ASN B 1 151 ? -3.27999  -3.42707  -5.06717  1.000 33.30361 ? 151 ASN B OD1 1 
ATOM   3435 N  ND2 . ASN B 1 151 ? -2.15402  -3.39653  -3.12638  1.000 29.32194 ? 151 ASN B ND2 1 
ATOM   3436 N  N   . ILE B 1 152 ? -7.20297  -1.32351  -3.49065  1.000 34.19485 ? 152 ILE B N   1 
ATOM   3437 C  CA  . ILE B 1 152 ? -8.57800  -1.05438  -3.08624  1.000 35.51139 ? 152 ILE B CA  1 
ATOM   3438 C  C   . ILE B 1 152 ? -9.35230  -2.36443  -3.06455  1.000 32.38073 ? 152 ILE B C   1 
ATOM   3439 O  O   . ILE B 1 152 ? -9.39460  -3.08322  -4.06929  1.000 42.47587 ? 152 ILE B O   1 
ATOM   3440 C  CB  . ILE B 1 152 ? -9.26103  -0.03795  -4.02045  1.000 35.17039 ? 152 ILE B CB  1 
ATOM   3441 C  CG1 . ILE B 1 152 ? -8.46895  1.27202   -4.05500  1.000 30.93374 ? 152 ILE B CG1 1 
ATOM   3442 C  CG2 . ILE B 1 152 ? -10.69491 0.21299   -3.57067  1.000 36.05891 ? 152 ILE B CG2 1 
ATOM   3443 C  CD1 . ILE B 1 152 ? -9.15628  2.37888   -4.81733  1.000 37.65972 ? 152 ILE B CD1 1 
ATOM   3444 N  N   . ASP B 1 153 ? -9.95662  -2.67371  -1.91975  1.000 42.35392 ? 153 ASP B N   1 
ATOM   3445 C  CA  . ASP B 1 153 ? -10.84397 -3.82015  -1.76550  1.000 44.77537 ? 153 ASP B CA  1 
ATOM   3446 C  C   . ASP B 1 153 ? -12.21162 -3.29629  -1.35225  1.000 53.69650 ? 153 ASP B C   1 
ATOM   3447 O  O   . ASP B 1 153 ? -12.35574 -2.72410  -0.26503  1.000 56.35427 ? 153 ASP B O   1 
ATOM   3448 C  CB  . ASP B 1 153 ? -10.30211 -4.80763  -0.73097  1.000 44.30206 ? 153 ASP B CB  1 
ATOM   3449 N  N   . TYR B 1 154 ? -13.20821 -3.49335  -2.21859  1.000 52.42280 ? 154 TYR B N   1 
ATOM   3450 C  CA  . TYR B 1 154 ? -14.52602 -2.88769  -2.05534  1.000 55.06989 ? 154 TYR B CA  1 
ATOM   3451 C  C   . TYR B 1 154 ? -14.39276 -1.37118  -1.97404  1.000 51.74119 ? 154 TYR B C   1 
ATOM   3452 O  O   . TYR B 1 154 ? -14.09449 -0.71498  -2.97713  1.000 51.20470 ? 154 TYR B O   1 
ATOM   3453 C  CB  . TYR B 1 154 ? -15.23739 -3.44332  -0.81771  1.000 55.95494 ? 154 TYR B CB  1 
ATOM   3454 N  N   . ASP B 1 155 ? -14.60166 -0.80565  -0.78699  1.000 48.99011 ? 155 ASP B N   1 
ATOM   3455 C  CA  . ASP B 1 155 ? -14.47023 0.62938   -0.57236  1.000 53.85104 ? 155 ASP B CA  1 
ATOM   3456 C  C   . ASP B 1 155 ? -13.29239 0.97959   0.32889   1.000 50.24088 ? 155 ASP B C   1 
ATOM   3457 O  O   . ASP B 1 155 ? -13.16058 2.13796   0.73990   1.000 45.18092 ? 155 ASP B O   1 
ATOM   3458 C  CB  . ASP B 1 155 ? -15.76546 1.19284   0.01679   1.000 53.22512 ? 155 ASP B CB  1 
ATOM   3459 C  CG  . ASP B 1 155 ? -16.09309 0.60204   1.37697   1.000 61.96091 ? 155 ASP B CG  1 
ATOM   3460 O  OD1 . ASP B 1 155 ? -15.58040 -0.49294  1.69205   1.000 62.22614 ? 155 ASP B OD1 1 
ATOM   3461 O  OD2 . ASP B 1 155 ? -16.86696 1.23000   2.13040   1.000 57.12197 ? 155 ASP B OD2 1 
ATOM   3462 N  N   . CYS B 1 156 ? -12.43201 0.01312   0.63750   1.000 47.33976 ? 156 CYS B N   1 
ATOM   3463 C  CA  . CYS B 1 156 ? -11.36732 0.17667   1.61927   1.000 41.19857 ? 156 CYS B CA  1 
ATOM   3464 C  C   . CYS B 1 156 ? -10.02623 0.31530   0.90739   1.000 37.14272 ? 156 CYS B C   1 
ATOM   3465 O  O   . CYS B 1 156 ? -9.63001  -0.56961  0.13993   1.000 33.70807 ? 156 CYS B O   1 
ATOM   3466 C  CB  . CYS B 1 156 ? -11.34459 -1.00757  2.58450   1.000 37.40923 ? 156 CYS B CB  1 
ATOM   3467 S  SG  . CYS B 1 156 ? -10.01359 -0.95541  3.79755   1.000 45.62296 ? 156 CYS B SG  1 
ATOM   3468 N  N   . VAL B 1 157 ? -9.32926  1.41486   1.17459   1.000 32.53317 ? 157 VAL B N   1 
ATOM   3469 C  CA  . VAL B 1 157 ? -8.01506  1.67205   0.59702   1.000 32.65851 ? 157 VAL B CA  1 
ATOM   3470 C  C   . VAL B 1 157 ? -6.95147  1.07091   1.50885   1.000 38.06974 ? 157 VAL B C   1 
ATOM   3471 O  O   . VAL B 1 157 ? -6.83673  1.44906   2.67916   1.000 39.35838 ? 157 VAL B O   1 
ATOM   3472 C  CB  . VAL B 1 157 ? -7.78067  3.17675   0.40253   1.000 30.89254 ? 157 VAL B CB  1 
ATOM   3473 C  CG1 . VAL B 1 157 ? -6.41548  3.42250   -0.23284  1.000 32.26717 ? 157 VAL B CG1 1 
ATOM   3474 C  CG2 . VAL B 1 157 ? -8.89348  3.78346   -0.43493  1.000 32.93294 ? 157 VAL B CG2 1 
ATOM   3475 N  N   . SER B 1 158 ? -6.16849  0.13887   0.97584   1.000 33.71327 ? 158 SER B N   1 
ATOM   3476 C  CA  . SER B 1 158 ? -5.05758  -0.46265  1.70887   1.000 34.24243 ? 158 SER B CA  1 
ATOM   3477 C  C   . SER B 1 158 ? -3.77263  0.23293   1.27241   1.000 31.06843 ? 158 SER B C   1 
ATOM   3478 O  O   . SER B 1 158 ? -3.19749  -0.09633  0.23227   1.000 30.84102 ? 158 SER B O   1 
ATOM   3479 C  CB  . SER B 1 158 ? -4.99370  -1.96765  1.46852   1.000 34.39092 ? 158 SER B CB  1 
ATOM   3480 O  OG  . SER B 1 158 ? -6.02941  -2.63947  2.16792   1.000 39.88693 ? 158 SER B OG  1 
ATOM   3481 N  N   . PHE B 1 159 ? -3.32752  1.20308   2.06789   1.000 29.28676 ? 159 PHE B N   1 
ATOM   3482 C  CA  . PHE B 1 159 ? -2.05316  1.85696   1.80380   1.000 27.02281 ? 159 PHE B CA  1 
ATOM   3483 C  C   . PHE B 1 159 ? -0.90768  0.90425   2.12643   1.000 27.47321 ? 159 PHE B C   1 
ATOM   3484 O  O   . PHE B 1 159 ? -0.86289  0.31687   3.21199   1.000 29.19389 ? 159 PHE B O   1 
ATOM   3485 C  CB  . PHE B 1 159 ? -1.92580  3.13469   2.63094   1.000 28.78112 ? 159 PHE B CB  1 
ATOM   3486 C  CG  . PHE B 1 159 ? -2.95455  4.18022   2.30306   1.000 28.07660 ? 159 PHE B CG  1 
ATOM   3487 C  CD1 . PHE B 1 159 ? -2.86613  4.91401   1.13137   1.000 28.52040 ? 159 PHE B CD1 1 
ATOM   3488 C  CD2 . PHE B 1 159 ? -3.99915  4.44117   3.17409   1.000 33.34856 ? 159 PHE B CD2 1 
ATOM   3489 C  CE1 . PHE B 1 159 ? -3.80604  5.88292   0.83030   1.000 29.12694 ? 159 PHE B CE1 1 
ATOM   3490 C  CE2 . PHE B 1 159 ? -4.94289  5.40918   2.87962   1.000 29.93344 ? 159 PHE B CE2 1 
ATOM   3491 C  CZ  . PHE B 1 159 ? -4.84616  6.13072   1.70818   1.000 31.08301 ? 159 PHE B CZ  1 
ATOM   3492 N  N   . CYS B 1 160 ? 0.02720   0.75585   1.18663   1.000 28.68484 ? 160 CYS B N   1 
ATOM   3493 C  CA  . CYS B 1 160 ? 1.11974   -0.19364  1.34898   1.000 31.21474 ? 160 CYS B CA  1 
ATOM   3494 C  C   . CYS B 1 160 ? 2.50116   0.37975   1.07791   1.000 32.18936 ? 160 CYS B C   1 
ATOM   3495 O  O   . CYS B 1 160 ? 3.49205   -0.29847  1.37201   1.000 33.43751 ? 160 CYS B O   1 
ATOM   3496 C  CB  . CYS B 1 160 ? 0.91314   -1.41018  0.43398   1.000 29.40884 ? 160 CYS B CB  1 
ATOM   3497 S  SG  . CYS B 1 160 ? 0.95853   -1.01809  -1.32718  1.000 32.43103 ? 160 CYS B SG  1 
ATOM   3498 N  N   . TYR B 1 161 ? 2.60720   1.59198   0.54177   1.000 28.31473 ? 161 TYR B N   1 
ATOM   3499 C  CA  . TYR B 1 161 ? 3.90028   2.12735   0.14846   1.000 29.45492 ? 161 TYR B CA  1 
ATOM   3500 C  C   . TYR B 1 161 ? 3.89644   3.64076   0.29320   1.000 30.14353 ? 161 TYR B C   1 
ATOM   3501 O  O   . TYR B 1 161 ? 2.87426   4.28977   0.06439   1.000 28.08814 ? 161 TYR B O   1 
ATOM   3502 C  CB  . TYR B 1 161 ? 4.23514   1.73454   -1.29498  1.000 27.11049 ? 161 TYR B CB  1 
ATOM   3503 C  CG  . TYR B 1 161 ? 5.56741   2.24650   -1.79625  1.000 27.05444 ? 161 TYR B CG  1 
ATOM   3504 C  CD1 . TYR B 1 161 ? 6.74813   1.58904   -1.48019  1.000 29.17436 ? 161 TYR B CD1 1 
ATOM   3505 C  CD2 . TYR B 1 161 ? 5.64232   3.37510   -2.60169  1.000 28.46240 ? 161 TYR B CD2 1 
ATOM   3506 C  CE1 . TYR B 1 161 ? 7.96973   2.04901   -1.94230  1.000 25.32249 ? 161 TYR B CE1 1 
ATOM   3507 C  CE2 . TYR B 1 161 ? 6.85679   3.84147   -3.07100  1.000 28.93404 ? 161 TYR B CE2 1 
ATOM   3508 C  CZ  . TYR B 1 161 ? 8.01854   3.17596   -2.73785  1.000 34.38093 ? 161 TYR B CZ  1 
ATOM   3509 O  OH  . TYR B 1 161 ? 9.23117   3.63727   -3.20699  1.000 30.50546 ? 161 TYR B OH  1 
ATOM   3510 N  N   . MET B 1 162 ? 5.04183   4.18915   0.69273   1.000 31.49465 ? 162 MET B N   1 
ATOM   3511 C  CA  . MET B 1 162 ? 5.31034   5.61948   0.62369   1.000 30.11431 ? 162 MET B CA  1 
ATOM   3512 C  C   . MET B 1 162 ? 6.69614   5.79956   0.02869   1.000 33.72821 ? 162 MET B C   1 
ATOM   3513 O  O   . MET B 1 162 ? 7.64906   5.14596   0.46600   1.000 31.30136 ? 162 MET B O   1 
ATOM   3514 C  CB  . MET B 1 162 ? 5.22628   6.29305   2.00076   1.000 32.22204 ? 162 MET B CB  1 
ATOM   3515 C  CG  . MET B 1 162 ? 5.76465   7.72221   2.01500   1.000 34.27636 ? 162 MET B CG  1 
ATOM   3516 S  SD  . MET B 1 162 ? 5.39129   8.64332   3.51800   1.000 42.85456 ? 162 MET B SD  1 
ATOM   3517 C  CE  . MET B 1 162 ? 3.63793   8.94778   3.29814   1.000 38.86251 ? 162 MET B CE  1 
ATOM   3518 N  N   . HIS B 1 163 ? 6.80560   6.67194   -0.96936  1.000 32.54371 ? 163 HIS B N   1 
ATOM   3519 C  CA  . HIS B 1 163 ? 8.05326   6.81812   -1.70435  1.000 34.61557 ? 163 HIS B CA  1 
ATOM   3520 C  C   . HIS B 1 163 ? 9.02557   7.70724   -0.93986  1.000 36.24497 ? 163 HIS B C   1 
ATOM   3521 O  O   . HIS B 1 163 ? 8.64866   8.77371   -0.44306  1.000 33.90844 ? 163 HIS B O   1 
ATOM   3522 C  CB  . HIS B 1 163 ? 7.79352   7.39468   -3.09438  1.000 30.19304 ? 163 HIS B CB  1 
ATOM   3523 C  CG  . HIS B 1 163 ? 9.03093   7.53642   -3.92088  1.000 32.61030 ? 163 HIS B CG  1 
ATOM   3524 N  ND1 . HIS B 1 163 ? 9.89774   6.48876   -4.14352  1.000 38.65300 ? 163 HIS B ND1 1 
ATOM   3525 C  CD2 . HIS B 1 163 ? 9.55694   8.60411   -4.56515  1.000 35.11072 ? 163 HIS B CD2 1 
ATOM   3526 C  CE1 . HIS B 1 163 ? 10.90128  6.90322   -4.89516  1.000 37.35704 ? 163 HIS B CE1 1 
ATOM   3527 N  NE2 . HIS B 1 163 ? 10.71844  8.18277   -5.16538  1.000 41.96900 ? 163 HIS B NE2 1 
ATOM   3528 N  N   . HIS B 1 164 ? 10.28215  7.27100   -0.86030  1.000 36.09089 ? 164 HIS B N   1 
ATOM   3529 C  CA  . HIS B 1 164 ? 11.31310  7.99464   -0.12819  1.000 36.75373 ? 164 HIS B CA  1 
ATOM   3530 C  C   . HIS B 1 164 ? 12.45861  8.46341   -1.01124  1.000 37.82484 ? 164 HIS B C   1 
ATOM   3531 O  O   . HIS B 1 164 ? 12.85840  9.62995   -0.92115  1.000 39.28027 ? 164 HIS B O   1 
ATOM   3532 C  CB  . HIS B 1 164 ? 11.85624  7.12200   1.01471   1.000 35.51294 ? 164 HIS B CB  1 
ATOM   3533 C  CG  . HIS B 1 164 ? 10.94872  7.04977   2.20400   1.000 39.58854 ? 164 HIS B CG  1 
ATOM   3534 N  ND1 . HIS B 1 164 ? 11.26167  7.62895   3.41491   1.000 30.31178 ? 164 HIS B ND1 1 
ATOM   3535 C  CD2 . HIS B 1 164 ? 9.73490   6.47113   2.36620   1.000 32.01201 ? 164 HIS B CD2 1 
ATOM   3536 C  CE1 . HIS B 1 164 ? 10.28188  7.40622   4.27287   1.000 39.77755 ? 164 HIS B CE1 1 
ATOM   3537 N  NE2 . HIS B 1 164 ? 9.34250   6.70760   3.66088   1.000 35.56636 ? 164 HIS B NE2 1 
ATOM   3538 N  N   . MET B 1 165 ? 13.00528  7.60077   -1.86642  1.000 35.99072 ? 165 MET B N   1 
ATOM   3539 C  CA  . MET B 1 165 ? 14.22572  7.96966   -2.57253  1.000 45.42848 ? 165 MET B CA  1 
ATOM   3540 C  C   . MET B 1 165 ? 14.37371  7.15660   -3.84930  1.000 40.92035 ? 165 MET B C   1 
ATOM   3541 O  O   . MET B 1 165 ? 13.72360  6.12521   -4.03688  1.000 40.33266 ? 165 MET B O   1 
ATOM   3542 C  CB  . MET B 1 165 ? 15.45620  7.76856   -1.68391  1.000 39.68970 ? 165 MET B CB  1 
ATOM   3543 C  CG  . MET B 1 165 ? 15.72710  6.31296   -1.34456  1.000 41.31271 ? 165 MET B CG  1 
ATOM   3544 S  SD  . MET B 1 165 ? 16.79961  6.11805   0.09334   1.000 57.42506 ? 165 MET B SD  1 
ATOM   3545 C  CE  . MET B 1 165 ? 17.02594  4.34567   0.09384   1.000 37.06527 ? 165 MET B CE  1 
ATOM   3546 N  N   . GLU B 1 166 ? 15.25569  7.63990   -4.71978  1.000 47.95236 ? 166 GLU B N   1 
ATOM   3547 C  CA  . GLU B 1 166 ? 15.67607  6.92530   -5.91489  1.000 48.14547 ? 166 GLU B CA  1 
ATOM   3548 C  C   . GLU B 1 166 ? 17.08920  6.39780   -5.71041  1.000 42.59352 ? 166 GLU B C   1 
ATOM   3549 O  O   . GLU B 1 166 ? 17.93610  7.07798   -5.12222  1.000 43.04830 ? 166 GLU B O   1 
ATOM   3550 C  CB  . GLU B 1 166 ? 15.62837  7.82951   -7.15205  1.000 42.73517 ? 166 GLU B CB  1 
ATOM   3551 C  CG  . GLU B 1 166 ? 16.12162  7.16044   -8.43333  1.000 51.82562 ? 166 GLU B CG  1 
ATOM   3552 C  CD  . GLU B 1 166 ? 16.15927  8.10420   -9.62473  1.000 61.65385 ? 166 GLU B CD  1 
ATOM   3553 O  OE1 . GLU B 1 166 ? 15.21084  8.89923   -9.79280  1.000 68.52645 ? 166 GLU B OE1 1 
ATOM   3554 O  OE2 . GLU B 1 166 ? 17.14309  8.05196   -10.39355 1.000 57.78791 ? 166 GLU B OE2 1 
ATOM   3555 N  N   . LEU B 1 167 ? 17.33383  5.18586   -6.18662  1.000 39.40363 ? 167 LEU B N   1 
ATOM   3556 C  CA  . LEU B 1 167 ? 18.62958  4.53027   -6.11405  1.000 46.05713 ? 167 LEU B CA  1 
ATOM   3557 C  C   . LEU B 1 167 ? 19.41778  4.75865   -7.39979  1.000 52.10744 ? 167 LEU B C   1 
ATOM   3558 O  O   . LEU B 1 167 ? 18.84346  5.09933   -8.43860  1.000 52.45356 ? 167 LEU B O   1 
ATOM   3559 C  CB  . LEU B 1 167 ? 18.44006  3.03104   -5.85398  1.000 42.19580 ? 167 LEU B CB  1 
ATOM   3560 C  CG  . LEU B 1 167 ? 17.99367  2.71509   -4.42306  1.000 46.89833 ? 167 LEU B CG  1 
ATOM   3561 C  CD1 . LEU B 1 167 ? 17.69073  1.23435   -4.25257  1.000 43.10061 ? 167 LEU B CD1 1 
ATOM   3562 C  CD2 . LEU B 1 167 ? 19.04923  3.16994   -3.42366  1.000 44.54797 ? 167 LEU B CD2 1 
ATOM   3563 N  N   . PRO B 1 168 ? 20.74627  4.59094   -7.36529  1.000 54.38761 ? 168 PRO B N   1 
ATOM   3564 C  CA  . PRO B 1 168 ? 21.57097  4.99353   -8.52135  1.000 51.66257 ? 168 PRO B CA  1 
ATOM   3565 C  C   . PRO B 1 168 ? 21.21915  4.30688   -9.83366  1.000 56.70515 ? 168 PRO B C   1 
ATOM   3566 O  O   . PRO B 1 168 ? 21.59888  4.81783   -10.89502 1.000 66.64030 ? 168 PRO B O   1 
ATOM   3567 C  CB  . PRO B 1 168 ? 22.99485  4.63472   -8.07475  1.000 54.96563 ? 168 PRO B CB  1 
ATOM   3568 C  CG  . PRO B 1 168 ? 22.94433  4.69076   -6.59222  1.000 63.17109 ? 168 PRO B CG  1 
ATOM   3569 C  CD  . PRO B 1 168 ? 21.58020  4.18713   -6.21827  1.000 58.94392 ? 168 PRO B CD  1 
ATOM   3570 N  N   . THR B 1 169 ? 20.51535  3.17834   -9.80979  1.000 54.30840 ? 169 THR B N   1 
ATOM   3571 C  CA  . THR B 1 169 ? 20.15264  2.47928   -11.03589 1.000 51.33139 ? 169 THR B CA  1 
ATOM   3572 C  C   . THR B 1 169 ? 18.81720  2.93824   -11.61089 1.000 54.83182 ? 169 THR B C   1 
ATOM   3573 O  O   . THR B 1 169 ? 18.34485  2.35195   -12.59078 1.000 52.27308 ? 169 THR B O   1 
ATOM   3574 C  CB  . THR B 1 169 ? 20.11847  0.96767   -10.79626 1.000 48.93678 ? 169 THR B CB  1 
ATOM   3575 O  OG1 . THR B 1 169 ? 19.40404  0.68974   -9.58528  1.000 51.25143 ? 169 THR B OG1 1 
ATOM   3576 C  CG2 . THR B 1 169 ? 21.53349  0.41219   -10.69284 1.000 54.80755 ? 169 THR B CG2 1 
ATOM   3577 N  N   . GLY B 1 170 ? 18.20320  3.96859   -11.03308 1.000 50.68574 ? 170 GLY B N   1 
ATOM   3578 C  CA  . GLY B 1 170 ? 16.92960  4.46416   -11.50754 1.000 53.71882 ? 170 GLY B CA  1 
ATOM   3579 C  C   . GLY B 1 170 ? 15.71156  3.84940   -10.85300 1.000 52.77551 ? 170 GLY B C   1 
ATOM   3580 O  O   . GLY B 1 170 ? 14.59048  4.29640   -11.12866 1.000 56.09611 ? 170 GLY B O   1 
ATOM   3581 N  N   . VAL B 1 171 ? 15.88875  2.84056   -10.00160 1.000 46.45289 ? 171 VAL B N   1 
ATOM   3582 C  CA  . VAL B 1 171 ? 14.77233  2.22532   -9.29416  1.000 48.56663 ? 171 VAL B CA  1 
ATOM   3583 C  C   . VAL B 1 171 ? 14.50629  3.01213   -8.01729  1.000 45.39541 ? 171 VAL B C   1 
ATOM   3584 O  O   . VAL B 1 171 ? 15.23245  3.95960   -7.69600  1.000 42.71232 ? 171 VAL B O   1 
ATOM   3585 C  CB  . VAL B 1 171 ? 15.04773  0.74082   -8.99830  1.000 43.54610 ? 171 VAL B CB  1 
ATOM   3586 C  CG1 . VAL B 1 171 ? 15.20436  -0.03155  -10.30146 1.000 43.32373 ? 171 VAL B CG1 1 
ATOM   3587 C  CG2 . VAL B 1 171 ? 16.28580  0.59437   -8.13183  1.000 41.40457 ? 171 VAL B CG2 1 
ATOM   3588 N  N   . HIS B 1 172 ? 13.46977  2.62641   -7.27790  1.000 40.67206 ? 172 HIS B N   1 
ATOM   3589 C  CA  . HIS B 1 172 ? 12.96312  3.44073   -6.18482  1.000 37.98075 ? 172 HIS B CA  1 
ATOM   3590 C  C   . HIS B 1 172 ? 12.80070  2.61146   -4.91895  1.000 36.37496 ? 172 HIS B C   1 
ATOM   3591 O  O   . HIS B 1 172 ? 12.48781  1.41775   -4.96873  1.000 32.86326 ? 172 HIS B O   1 
ATOM   3592 C  CB  . HIS B 1 172 ? 11.63465  4.09365   -6.57498  1.000 34.26005 ? 172 HIS B CB  1 
ATOM   3593 C  CG  . HIS B 1 172 ? 11.73453  4.96025   -7.79146  1.000 49.96764 ? 172 HIS B CG  1 
ATOM   3594 N  ND1 . HIS B 1 172 ? 11.54093  4.47670   -9.06771  1.000 53.73178 ? 172 HIS B ND1 1 
ATOM   3595 C  CD2 . HIS B 1 172 ? 12.03758  6.27317   -7.92895  1.000 52.98885 ? 172 HIS B CD2 1 
ATOM   3596 C  CE1 . HIS B 1 172 ? 11.70399  5.45789   -9.93738  1.000 51.94749 ? 172 HIS B CE1 1 
ATOM   3597 N  NE2 . HIS B 1 172 ? 12.00540  6.55865   -9.27242  1.000 53.85425 ? 172 HIS B NE2 1 
ATOM   3598 N  N   . ALA B 1 173 ? 13.02096  3.26779   -3.78004  1.000 29.27842 ? 173 ALA B N   1 
ATOM   3599 C  CA  . ALA B 1 173 ? 12.94641  2.64188   -2.46939  1.000 28.61872 ? 173 ALA B CA  1 
ATOM   3600 C  C   . ALA B 1 173 ? 12.01790  3.44756   -1.57391  1.000 33.12919 ? 173 ALA B C   1 
ATOM   3601 O  O   . ALA B 1 173 ? 11.96394  4.67851   -1.66648  1.000 32.06026 ? 173 ALA B O   1 
ATOM   3602 C  CB  . ALA B 1 173 ? 14.33472  2.53560   -1.82566  1.000 29.92885 ? 173 ALA B CB  1 
ATOM   3603 N  N   . GLY B 1 174 ? 11.29082  2.74892   -0.71025  1.000 25.47391 ? 174 GLY B N   1 
ATOM   3604 C  CA  . GLY B 1 174 ? 10.35976  3.40140   0.17924   1.000 24.45703 ? 174 GLY B CA  1 
ATOM   3605 C  C   . GLY B 1 174 ? 9.96466   2.50084   1.32729   1.000 27.17958 ? 174 GLY B C   1 
ATOM   3606 O  O   . GLY B 1 174 ? 10.55295  1.43924   1.54457   1.000 30.80049 ? 174 GLY B O   1 
ATOM   3607 N  N   . THR B 1 175 ? 8.94822   2.94125   2.06201   1.000 29.15059 ? 175 THR B N   1 
ATOM   3608 C  CA  . THR B 1 175 ? 8.51661   2.27505   3.28037   1.000 30.94907 ? 175 THR B CA  1 
ATOM   3609 C  C   . THR B 1 175 ? 7.03121   1.95353   3.19999   1.000 30.55317 ? 175 THR B C   1 
ATOM   3610 O  O   . THR B 1 175 ? 6.31968   2.39799   2.29486   1.000 31.60474 ? 175 THR B O   1 
ATOM   3611 C  CB  . THR B 1 175 ? 8.77856   3.14382   4.51885   1.000 31.53369 ? 175 THR B CB  1 
ATOM   3612 O  OG1 . THR B 1 175 ? 7.88388   4.26437   4.51067   1.000 30.13045 ? 175 THR B OG1 1 
ATOM   3613 C  CG2 . THR B 1 175 ? 10.21473  3.64684   4.53468   1.000 30.23247 ? 175 THR B CG2 1 
ATOM   3614 N  N   . ASP B 1 176 ? 6.56305   1.16980   4.16789   1.000 30.39473 ? 176 ASP B N   1 
ATOM   3615 C  CA  . ASP B 1 176 ? 5.13194   1.06922   4.38912   1.000 30.08455 ? 176 ASP B CA  1 
ATOM   3616 C  C   . ASP B 1 176 ? 4.66325   2.31837   5.13135   1.000 32.88871 ? 176 ASP B C   1 
ATOM   3617 O  O   . ASP B 1 176 ? 5.45871   3.18732   5.50145   1.000 33.18725 ? 176 ASP B O   1 
ATOM   3618 C  CB  . ASP B 1 176 ? 4.78316   -0.22286  5.13367   1.000 26.02984 ? 176 ASP B CB  1 
ATOM   3619 C  CG  . ASP B 1 176 ? 5.46281   -0.34087  6.50059   1.000 28.77071 ? 176 ASP B CG  1 
ATOM   3620 O  OD1 . ASP B 1 176 ? 5.74591   0.68530   7.15055   1.000 30.05114 ? 176 ASP B OD1 1 
ATOM   3621 O  OD2 . ASP B 1 176 ? 5.71393   -1.48684  6.92977   1.000 32.16235 ? 176 ASP B OD2 1 
ATOM   3622 N  N   . LEU B 1 177 ? 3.35843   2.41665   5.36670   1.000 31.14812 ? 177 LEU B N   1 
ATOM   3623 C  CA  . LEU B 1 177 ? 2.85702   3.62110   6.01769   1.000 31.99359 ? 177 LEU B CA  1 
ATOM   3624 C  C   . LEU B 1 177 ? 3.18848   3.67308   7.50324   1.000 31.76101 ? 177 LEU B C   1 
ATOM   3625 O  O   . LEU B 1 177 ? 2.86552   4.67206   8.15557   1.000 37.64241 ? 177 LEU B O   1 
ATOM   3626 C  CB  . LEU B 1 177 ? 1.34776   3.74517   5.80130   1.000 35.71324 ? 177 LEU B CB  1 
ATOM   3627 C  CG  . LEU B 1 177 ? 0.94001   4.57506   4.57964   1.000 35.14096 ? 177 LEU B CG  1 
ATOM   3628 C  CD1 . LEU B 1 177 ? 1.33903   6.03035   4.77259   1.000 34.40131 ? 177 LEU B CD1 1 
ATOM   3629 C  CD2 . LEU B 1 177 ? 1.55419   4.01911   3.30231   1.000 32.10749 ? 177 LEU B CD2 1 
ATOM   3630 N  N   . GLU B 1 178 ? 3.82828   2.63828   8.04543   1.000 33.84533 ? 178 GLU B N   1 
ATOM   3631 C  CA  . GLU B 1 178 ? 4.33258   2.64572   9.41020   1.000 32.48073 ? 178 GLU B CA  1 
ATOM   3632 C  C   . GLU B 1 178 ? 5.83248   2.90735   9.46898   1.000 30.80934 ? 178 GLU B C   1 
ATOM   3633 O  O   . GLU B 1 178 ? 6.45029   2.69679   10.51719  1.000 35.03777 ? 178 GLU B O   1 
ATOM   3634 C  CB  . GLU B 1 178 ? 3.99352   1.32511   10.10291  1.000 34.50073 ? 178 GLU B CB  1 
ATOM   3635 C  CG  . GLU B 1 178 ? 2.49519   1.06638   10.20729  1.000 36.46184 ? 178 GLU B CG  1 
ATOM   3636 C  CD  . GLU B 1 178 ? 2.16774   -0.21514  10.94634  1.000 42.31045 ? 178 GLU B CD  1 
ATOM   3637 O  OE1 . GLU B 1 178 ? 3.00511   -1.14032  10.93815  1.000 46.34570 ? 178 GLU B OE1 1 
ATOM   3638 O  OE2 . GLU B 1 178 ? 1.07082   -0.29409  11.53959  1.000 58.13762 ? 178 GLU B OE2 1 
ATOM   3639 N  N   . GLY B 1 179 ? 6.43026   3.35411   8.36593   1.000 30.95918 ? 179 GLY B N   1 
ATOM   3640 C  CA  . GLY B 1 179 ? 7.81038   3.78969   8.35689   1.000 28.91423 ? 179 GLY B CA  1 
ATOM   3641 C  C   . GLY B 1 179 ? 8.84965   2.70113   8.20389   1.000 32.01832 ? 179 GLY B C   1 
ATOM   3642 O  O   . GLY B 1 179 ? 10.04740  3.00980   8.24618   1.000 29.50515 ? 179 GLY B O   1 
ATOM   3643 N  N   . ASN B 1 180 ? 8.44632   1.44437   8.02862   1.000 30.23241 ? 180 ASN B N   1 
ATOM   3644 C  CA  . ASN B 1 180 ? 9.39389   0.34926   7.85822   1.000 27.44470 ? 180 ASN B CA  1 
ATOM   3645 C  C   . ASN B 1 180 ? 9.79699   0.25418   6.39234   1.000 31.66662 ? 180 ASN B C   1 
ATOM   3646 O  O   . ASN B 1 180 ? 8.93895   0.10400   5.51561   1.000 31.70381 ? 180 ASN B O   1 
ATOM   3647 C  CB  . ASN B 1 180 ? 8.79126   -0.97139  8.32930   1.000 26.87093 ? 180 ASN B CB  1 
ATOM   3648 C  CG  . ASN B 1 180 ? 8.27810   -0.90078  9.74661   1.000 28.91104 ? 180 ASN B CG  1 
ATOM   3649 O  OD1 . ASN B 1 180 ? 9.05502   -0.81463  10.69454  1.000 33.66755 ? 180 ASN B OD1 1 
ATOM   3650 N  ND2 . ASN B 1 180 ? 6.96208   -0.94132  9.90075   1.000 27.03021 ? 180 ASN B ND2 1 
ATOM   3651 N  N   . PHE B 1 181 ? 11.09778  0.32620   6.13113   1.000 30.41016 ? 181 PHE B N   1 
ATOM   3652 C  CA  . PHE B 1 181 ? 11.58340  0.26990   4.76006   1.000 31.12415 ? 181 PHE B CA  1 
ATOM   3653 C  C   . PHE B 1 181 ? 11.30434  -1.09019  4.13536   1.000 26.62364 ? 181 PHE B C   1 
ATOM   3654 O  O   . PHE B 1 181 ? 11.30951  -2.12491  4.80802   1.000 28.86657 ? 181 PHE B O   1 
ATOM   3655 C  CB  . PHE B 1 181 ? 13.08493  0.55796   4.70729   1.000 27.98556 ? 181 PHE B CB  1 
ATOM   3656 C  CG  . PHE B 1 181 ? 13.42247  1.90539   4.14106   1.000 32.53658 ? 181 PHE B CG  1 
ATOM   3657 C  CD1 . PHE B 1 181 ? 13.49708  2.09798   2.77042   1.000 26.07011 ? 181 PHE B CD1 1 
ATOM   3658 C  CD2 . PHE B 1 181 ? 13.66779  2.98087   4.97984   1.000 32.06641 ? 181 PHE B CD2 1 
ATOM   3659 C  CE1 . PHE B 1 181 ? 13.80544  3.33862   2.24768   1.000 30.68048 ? 181 PHE B CE1 1 
ATOM   3660 C  CE2 . PHE B 1 181 ? 13.97700  4.22560   4.46095   1.000 34.59070 ? 181 PHE B CE2 1 
ATOM   3661 C  CZ  . PHE B 1 181 ? 14.04726  4.40365   3.09477   1.000 31.57916 ? 181 PHE B CZ  1 
ATOM   3662 N  N   . TYR B 1 182 ? 11.03702  -1.07302  2.83304   1.000 26.60620 ? 182 TYR B N   1 
ATOM   3663 C  CA  . TYR B 1 182 ? 11.09189  -2.27494  2.01453   1.000 29.44660 ? 182 TYR B CA  1 
ATOM   3664 C  C   . TYR B 1 182 ? 12.52407  -2.43415  1.52079   1.000 30.95150 ? 182 TYR B C   1 
ATOM   3665 O  O   . TYR B 1 182 ? 13.05279  -1.54470  0.84467   1.000 27.14242 ? 182 TYR B O   1 
ATOM   3666 C  CB  . TYR B 1 182 ? 10.12294  -2.19315  0.83579   1.000 26.30206 ? 182 TYR B CB  1 
ATOM   3667 C  CG  . TYR B 1 182 ? 8.66059   -2.26871  1.21298   1.000 27.84923 ? 182 TYR B CG  1 
ATOM   3668 C  CD1 . TYR B 1 182 ? 8.05524   -3.48933  1.48370   1.000 30.40726 ? 182 TYR B CD1 1 
ATOM   3669 C  CD2 . TYR B 1 182 ? 7.88100   -1.12194  1.27968   1.000 30.52365 ? 182 TYR B CD2 1 
ATOM   3670 C  CE1 . TYR B 1 182 ? 6.71676   -3.56590  1.82234   1.000 30.20653 ? 182 TYR B CE1 1 
ATOM   3671 C  CE2 . TYR B 1 182 ? 6.53734   -1.18815  1.61887   1.000 26.91840 ? 182 TYR B CE2 1 
ATOM   3672 C  CZ  . TYR B 1 182 ? 5.96315   -2.41333  1.88905   1.000 30.00513 ? 182 TYR B CZ  1 
ATOM   3673 O  OH  . TYR B 1 182 ? 4.63131   -2.49347  2.22237   1.000 31.16345 ? 182 TYR B OH  1 
ATOM   3674 N  N   . GLY B 1 183 ? 13.15774  -3.54591  1.88010   1.000 29.98226 ? 183 GLY B N   1 
ATOM   3675 C  CA  . GLY B 1 183 ? 14.49916  -3.82753  1.42927   1.000 30.16277 ? 183 GLY B CA  1 
ATOM   3676 C  C   . GLY B 1 183 ? 15.57749  -3.29240  2.34432   1.000 33.21520 ? 183 GLY B C   1 
ATOM   3677 O  O   . GLY B 1 183 ? 15.31064  -2.58716  3.32287   1.000 34.16024 ? 183 GLY B O   1 
ATOM   3678 N  N   . PRO B 1 184 ? 16.83185  -3.62380  2.03377   1.000 36.93244 ? 184 PRO B N   1 
ATOM   3679 C  CA  . PRO B 1 184 ? 17.96585  -3.23225  2.89625   1.000 34.19786 ? 184 PRO B CA  1 
ATOM   3680 C  C   . PRO B 1 184 ? 18.47747  -1.83155  2.57529   1.000 41.06851 ? 184 PRO B C   1 
ATOM   3681 O  O   . PRO B 1 184 ? 19.58776  -1.63014  2.06381   1.000 37.59480 ? 184 PRO B O   1 
ATOM   3682 C  CB  . PRO B 1 184 ? 18.99549  -4.32275  2.58936   1.000 31.12699 ? 184 PRO B CB  1 
ATOM   3683 C  CG  . PRO B 1 184 ? 18.75384  -4.64081  1.14467   1.000 32.71278 ? 184 PRO B CG  1 
ATOM   3684 C  CD  . PRO B 1 184 ? 17.26169  -4.47909  0.91286   1.000 28.60173 ? 184 PRO B CD  1 
ATOM   3685 N  N   . PHE B 1 185 ? 17.65858  -0.82774  2.88367   1.000 36.03212 ? 185 PHE B N   1 
ATOM   3686 C  CA  . PHE B 1 185 ? 17.96336  0.55194   2.54100   1.000 35.60961 ? 185 PHE B CA  1 
ATOM   3687 C  C   . PHE B 1 185 ? 17.68760  1.45608   3.73347   1.000 37.36712 ? 185 PHE B C   1 
ATOM   3688 O  O   . PHE B 1 185 ? 16.83829  1.15776   4.57754   1.000 37.27781 ? 185 PHE B O   1 
ATOM   3689 C  CB  . PHE B 1 185 ? 17.14691  1.01641   1.32484   1.000 34.20134 ? 185 PHE B CB  1 
ATOM   3690 C  CG  . PHE B 1 185 ? 17.17881  0.05291   0.17253   1.000 41.42725 ? 185 PHE B CG  1 
ATOM   3691 C  CD1 . PHE B 1 185 ? 18.35047  -0.16400  -0.53397  1.000 36.68834 ? 185 PHE B CD1 1 
ATOM   3692 C  CD2 . PHE B 1 185 ? 16.03770  -0.63741  -0.20281  1.000 33.72168 ? 185 PHE B CD2 1 
ATOM   3693 C  CE1 . PHE B 1 185 ? 18.38424  -1.05455  -1.59024  1.000 42.58159 ? 185 PHE B CE1 1 
ATOM   3694 C  CE2 . PHE B 1 185 ? 16.06536  -1.52903  -1.26001  1.000 36.69300 ? 185 PHE B CE2 1 
ATOM   3695 C  CZ  . PHE B 1 185 ? 17.24001  -1.73659  -1.95496  1.000 39.52560 ? 185 PHE B CZ  1 
ATOM   3696 N  N   . VAL B 1 186 ? 18.42076  2.56723   3.79351   1.000 31.76361 ? 186 VAL B N   1 
ATOM   3697 C  CA  . VAL B 1 186 ? 18.27825  3.55506   4.85404   1.000 34.58538 ? 186 VAL B CA  1 
ATOM   3698 C  C   . VAL B 1 186 ? 18.03753  4.91918   4.22231   1.000 40.34957 ? 186 VAL B C   1 
ATOM   3699 O  O   . VAL B 1 186 ? 18.49962  5.20026   3.11162   1.000 36.69006 ? 186 VAL B O   1 
ATOM   3700 C  CB  . VAL B 1 186 ? 19.51635  3.59002   5.78168   1.000 40.11010 ? 186 VAL B CB  1 
ATOM   3701 C  CG1 . VAL B 1 186 ? 19.66867  2.26547   6.51397   1.000 34.02884 ? 186 VAL B CG1 1 
ATOM   3702 C  CG2 . VAL B 1 186 ? 20.77715  3.91072   4.98821   1.000 35.19477 ? 186 VAL B CG2 1 
ATOM   3703 N  N   . ASP B 1 187 ? 17.30191  5.77202   4.93835   1.000 35.63940 ? 187 ASP B N   1 
ATOM   3704 C  CA  . ASP B 1 187 ? 17.00607  7.12299   4.45657   1.000 42.10735 ? 187 ASP B CA  1 
ATOM   3705 C  C   . ASP B 1 187 ? 18.14677  8.06816   4.83927   1.000 46.51348 ? 187 ASP B C   1 
ATOM   3706 O  O   . ASP B 1 187 ? 18.04505  8.91050   5.73294   1.000 47.48954 ? 187 ASP B O   1 
ATOM   3707 C  CB  . ASP B 1 187 ? 15.66524  7.60361   4.99483   1.000 39.75700 ? 187 ASP B CB  1 
ATOM   3708 C  CG  . ASP B 1 187 ? 15.55324  7.46540   6.49865   1.000 42.40252 ? 187 ASP B CG  1 
ATOM   3709 O  OD1 . ASP B 1 187 ? 16.42034  6.80756   7.11117   1.000 37.65898 ? 187 ASP B OD1 1 
ATOM   3710 O  OD2 . ASP B 1 187 ? 14.59247  8.02204   7.06680   1.000 40.06390 ? 187 ASP B OD2 1 
ATOM   3711 N  N   . ARG B 1 188 ? 19.25375  7.91040   4.11806   1.000 47.96252 ? 188 ARG B N   1 
ATOM   3712 C  CA  . ARG B 1 188 ? 20.45214  8.71005   4.31978   1.000 49.17269 ? 188 ARG B CA  1 
ATOM   3713 C  C   . ARG B 1 188 ? 21.21995  8.76266   3.00681   1.000 54.94515 ? 188 ARG B C   1 
ATOM   3714 O  O   . ARG B 1 188 ? 21.25152  7.77862   2.26225   1.000 48.39261 ? 188 ARG B O   1 
ATOM   3715 C  CB  . ARG B 1 188 ? 21.32121  8.12809   5.44505   1.000 49.85472 ? 188 ARG B CB  1 
ATOM   3716 C  CG  . ARG B 1 188 ? 22.82114  8.30064   5.25237   1.000 60.41644 ? 188 ARG B CG  1 
ATOM   3717 C  CD  . ARG B 1 188 ? 23.57596  8.11228   6.55987   1.000 57.63403 ? 188 ARG B CD  1 
ATOM   3718 N  NE  . ARG B 1 188 ? 23.24280  6.85428   7.21795   1.000 70.84667 ? 188 ARG B NE  1 
ATOM   3719 C  CZ  . ARG B 1 188 ? 24.03125  5.78787   7.24743   1.000 65.48528 ? 188 ARG B CZ  1 
ATOM   3720 N  NH1 . ARG B 1 188 ? 25.22382  5.79227   6.67331   1.000 59.35574 ? 188 ARG B NH1 1 
ATOM   3721 N  NH2 . ARG B 1 188 ? 23.61416  4.69012   7.87249   1.000 43.66318 ? 188 ARG B NH2 1 
ATOM   3722 N  N   . GLN B 1 189 ? 21.81846  9.91784   2.71556   1.000 58.83745 ? 189 GLN B N   1 
ATOM   3723 C  CA  . GLN B 1 189 ? 22.61835  10.04371  1.50402   1.000 62.45037 ? 189 GLN B CA  1 
ATOM   3724 C  C   . GLN B 1 189 ? 23.92066  9.26669   1.65372   1.000 63.63123 ? 189 GLN B C   1 
ATOM   3725 O  O   . GLN B 1 189 ? 24.92737  9.80558   2.12490   1.000 65.40676 ? 189 GLN B O   1 
ATOM   3726 C  CB  . GLN B 1 189 ? 22.89749  11.51313  1.18154   1.000 64.10440 ? 189 GLN B CB  1 
ATOM   3727 C  CG  . GLN B 1 189 ? 23.53357  11.72114  -0.18189  1.000 68.59316 ? 189 GLN B CG  1 
ATOM   3728 C  CD  . GLN B 1 189 ? 23.51620  13.16969  -0.62298  1.000 76.88328 ? 189 GLN B CD  1 
ATOM   3729 O  OE1 . GLN B 1 189 ? 23.18702  14.06663  0.15501   1.000 79.15723 ? 189 GLN B OE1 1 
ATOM   3730 N  NE2 . GLN B 1 189 ? 23.86709  13.40613  -1.88136  1.000 73.50683 ? 189 GLN B NE2 1 
ATOM   3731 N  N   . THR B 1 190 ? 23.90050  7.99298   1.26795   1.000 63.74378 ? 190 THR B N   1 
ATOM   3732 C  CA  . THR B 1 190 ? 25.06419  7.12398   1.34003   1.000 58.33117 ? 190 THR B CA  1 
ATOM   3733 C  C   . THR B 1 190 ? 25.08416  6.25159   0.09246   1.000 57.10057 ? 190 THR B C   1 
ATOM   3734 O  O   . THR B 1 190 ? 24.20309  6.34068   -0.76708  1.000 61.42514 ? 190 THR B O   1 
ATOM   3735 C  CB  . THR B 1 190 ? 25.04946  6.27086   2.61606   1.000 57.49214 ? 190 THR B CB  1 
ATOM   3736 O  OG1 . THR B 1 190 ? 26.23689  5.47066   2.67651   1.000 61.66796 ? 190 THR B OG1 1 
ATOM   3737 C  CG2 . THR B 1 190 ? 23.83316  5.35625   2.63418   1.000 55.85006 ? 190 THR B CG2 1 
ATOM   3738 N  N   . ALA B 1 191 ? 26.09823  5.39786   -0.00596  1.000 61.76585 ? 191 ALA B N   1 
ATOM   3739 C  CA  . ALA B 1 191 ? 26.25378  4.50249   -1.15060  1.000 57.52847 ? 191 ALA B CA  1 
ATOM   3740 C  C   . ALA B 1 191 ? 25.43413  3.24392   -0.89968  1.000 56.45189 ? 191 ALA B C   1 
ATOM   3741 O  O   . ALA B 1 191 ? 25.82998  2.37595   -0.11907  1.000 64.72280 ? 191 ALA B O   1 
ATOM   3742 C  CB  . ALA B 1 191 ? 27.72434  4.17543   -1.38377  1.000 58.73896 ? 191 ALA B CB  1 
ATOM   3743 N  N   . GLN B 1 192 ? 24.28298  3.14565   -1.56039  1.000 51.73730 ? 192 GLN B N   1 
ATOM   3744 C  CA  . GLN B 1 192 ? 23.43754  1.96270   -1.48162  1.000 55.57173 ? 192 GLN B CA  1 
ATOM   3745 C  C   . GLN B 1 192 ? 22.97111  1.57890   -2.87507  1.000 50.72282 ? 192 GLN B C   1 
ATOM   3746 O  O   . GLN B 1 192 ? 22.55155  2.44102   -3.65340  1.000 51.94131 ? 192 GLN B O   1 
ATOM   3747 C  CB  . GLN B 1 192 ? 22.23014  2.18704   -0.56188  1.000 51.88366 ? 192 GLN B CB  1 
ATOM   3748 C  CG  . GLN B 1 192 ? 21.84014  3.63532   -0.34175  1.000 48.06574 ? 192 GLN B CG  1 
ATOM   3749 C  CD  . GLN B 1 192 ? 20.82862  3.78753   0.77675   1.000 37.90605 ? 192 GLN B CD  1 
ATOM   3750 O  OE1 . GLN B 1 192 ? 20.36184  2.79800   1.34057   1.000 39.95567 ? 192 GLN B OE1 1 
ATOM   3751 N  NE2 . GLN B 1 192 ? 20.48801  5.02816   1.10729   1.000 41.49912 ? 192 GLN B NE2 1 
ATOM   3752 N  N   . ALA B 1 193 ? 23.05637  0.28791   -3.18406  1.000 49.54146 ? 193 ALA B N   1 
ATOM   3753 C  CA  . ALA B 1 193 ? 22.58070  -0.25653  -4.44435  1.000 55.71370 ? 193 ALA B CA  1 
ATOM   3754 C  C   . ALA B 1 193 ? 21.60847  -1.39109  -4.16195  1.000 56.58953 ? 193 ALA B C   1 
ATOM   3755 O  O   . ALA B 1 193 ? 21.63855  -2.01339  -3.09778  1.000 48.69446 ? 193 ALA B O   1 
ATOM   3756 C  CB  . ALA B 1 193 ? 23.73600  -0.76536  -5.32013  1.000 42.96916 ? 193 ALA B CB  1 
ATOM   3757 N  N   . ALA B 1 194 ? 20.73774  -1.65230  -5.12853  1.000 52.92523 ? 194 ALA B N   1 
ATOM   3758 C  CA  . ALA B 1 194 ? 19.80150  -2.75624  -5.00697  1.000 53.88574 ? 194 ALA B CA  1 
ATOM   3759 C  C   . ALA B 1 194 ? 20.47926  -4.07211  -5.36385  1.000 50.84940 ? 194 ALA B C   1 
ATOM   3760 O  O   . ALA B 1 194 ? 21.34786  -4.13095  -6.23739  1.000 49.66145 ? 194 ALA B O   1 
ATOM   3761 C  CB  . ALA B 1 194 ? 18.58845  -2.53343  -5.90836  1.000 55.72597 ? 194 ALA B CB  1 
ATOM   3762 N  N   . GLY B 1 195 ? 20.07463  -5.13271  -4.67588  1.000 53.88106 ? 195 GLY B N   1 
ATOM   3763 C  CA  . GLY B 1 195 ? 20.57733  -6.45652  -4.98766  1.000 49.54922 ? 195 GLY B CA  1 
ATOM   3764 C  C   . GLY B 1 195 ? 20.17255  -6.90433  -6.38208  1.000 54.87630 ? 195 GLY B C   1 
ATOM   3765 O  O   . GLY B 1 195 ? 19.39918  -6.25886  -7.09006  1.000 46.94299 ? 195 GLY B O   1 
ATOM   3766 N  N   . THR B 1 196 ? 20.72740  -8.04614  -6.78694  1.000 54.61167 ? 196 THR B N   1 
ATOM   3767 C  CA  . THR B 1 196 ? 20.36603  -8.63411  -8.07096  1.000 49.03601 ? 196 THR B CA  1 
ATOM   3768 C  C   . THR B 1 196 ? 18.87460  -8.94408  -8.10494  1.000 49.81989 ? 196 THR B C   1 
ATOM   3769 O  O   . THR B 1 196 ? 18.38753  -9.79383  -7.35077  1.000 50.67296 ? 196 THR B O   1 
ATOM   3770 C  CB  . THR B 1 196 ? 21.18747  -9.89709  -8.34398  1.000 48.09260 ? 196 THR B CB  1 
ATOM   3771 O  OG1 . THR B 1 196 ? 22.51159  -9.52536  -8.74565  1.000 60.14567 ? 196 THR B OG1 1 
ATOM   3772 C  CG2 . THR B 1 196 ? 20.54841  -10.73076 -9.44682  1.000 50.93864 ? 196 THR B CG2 1 
ATOM   3773 N  N   . ASP B 1 197 ? 18.13949  -8.23722  -8.95659  1.000 43.06316 ? 197 ASP B N   1 
ATOM   3774 C  CA  . ASP B 1 197 ? 16.71215  -8.47189  -9.07165  1.000 45.98278 ? 197 ASP B CA  1 
ATOM   3775 C  C   . ASP B 1 197 ? 16.45378  -9.77787  -9.81919  1.000 48.80952 ? 197 ASP B C   1 
ATOM   3776 O  O   . ASP B 1 197 ? 17.30566  -10.28780 -10.55333 1.000 51.04337 ? 197 ASP B O   1 
ATOM   3777 C  CB  . ASP B 1 197 ? 16.03454  -7.30295  -9.78633  1.000 44.26564 ? 197 ASP B CB  1 
ATOM   3778 C  CG  . ASP B 1 197 ? 14.54436  -7.22869  -9.50262  1.000 47.31055 ? 197 ASP B CG  1 
ATOM   3779 O  OD1 . ASP B 1 197 ? 14.06778  -7.95881  -8.60598  1.000 41.80872 ? 197 ASP B OD1 1 
ATOM   3780 O  OD2 . ASP B 1 197 ? 13.84976  -6.43982  -10.17626 1.000 37.28868 ? 197 ASP B OD2 1 
ATOM   3781 N  N   . THR B 1 198 ? 15.26289  -10.33077 -9.60806  1.000 45.95371 ? 198 THR B N   1 
ATOM   3782 C  CA  . THR B 1 198 ? 14.86047  -11.57107 -10.25184 1.000 45.90314 ? 198 THR B CA  1 
ATOM   3783 C  C   . THR B 1 198 ? 13.44393  -11.41829 -10.78540 1.000 39.39105 ? 198 THR B C   1 
ATOM   3784 O  O   . THR B 1 198 ? 12.72316  -10.47717 -10.44301 1.000 36.51433 ? 198 THR B O   1 
ATOM   3785 C  CB  . THR B 1 198 ? 14.94920  -12.76374 -9.29116  1.000 42.19603 ? 198 THR B CB  1 
ATOM   3786 O  OG1 . THR B 1 198 ? 14.29103  -12.44124 -8.06089  1.000 43.02369 ? 198 THR B OG1 1 
ATOM   3787 C  CG2 . THR B 1 198 ? 16.40308  -13.11755 -9.01026  1.000 46.72074 ? 198 THR B CG2 1 
ATOM   3788 N  N   . THR B 1 199 ? 13.05097  -12.36134 -11.63588 1.000 41.55118 ? 199 THR B N   1 
ATOM   3789 C  CA  . THR B 1 199 ? 11.73024  -12.35513 -12.24610 1.000 38.72577 ? 199 THR B CA  1 
ATOM   3790 C  C   . THR B 1 199 ? 10.74065  -13.10687 -11.36430 1.000 36.51296 ? 199 THR B C   1 
ATOM   3791 O  O   . THR B 1 199 ? 11.05885  -14.16166 -10.80818 1.000 37.24215 ? 199 THR B O   1 
ATOM   3792 C  CB  . THR B 1 199 ? 11.77961  -12.98407 -13.64070 1.000 35.75899 ? 199 THR B CB  1 
ATOM   3793 O  OG1 . THR B 1 199 ? 12.75933  -12.30640 -14.43514 1.000 33.88159 ? 199 THR B OG1 1 
ATOM   3794 C  CG2 . THR B 1 199 ? 10.43162  -12.86897 -14.32789 1.000 36.35525 ? 199 THR B CG2 1 
ATOM   3795 N  N   . ILE B 1 200 ? 9.53597   -12.55329 -11.24051 1.000 34.61798 ? 200 ILE B N   1 
ATOM   3796 C  CA  . ILE B 1 200 ? 8.48548   -13.13574 -10.40984 1.000 32.72253 ? 200 ILE B CA  1 
ATOM   3797 C  C   . ILE B 1 200 ? 7.81407   -14.23144 -11.23456 1.000 41.49793 ? 200 ILE B C   1 
ATOM   3798 O  O   . ILE B 1 200 ? 6.97269   -13.95516 -12.09060 1.000 39.54191 ? 200 ILE B O   1 
ATOM   3799 C  CB  . ILE B 1 200 ? 7.48664   -12.07778 -9.93960  1.000 38.23734 ? 200 ILE B CB  1 
ATOM   3800 C  CG1 . ILE B 1 200 ? 8.24243   -10.87180 -9.37264  1.000 30.42157 ? 200 ILE B CG1 1 
ATOM   3801 C  CG2 . ILE B 1 200 ? 6.54383   -12.66033 -8.89638  1.000 28.09067 ? 200 ILE B CG2 1 
ATOM   3802 C  CD1 . ILE B 1 200 ? 7.42196   -9.60203  -9.31187  1.000 32.74159 ? 200 ILE B CD1 1 
ATOM   3803 N  N   . THR B 1 201 ? 8.18288   -15.48679 -10.96478 1.000 42.36502 ? 201 THR B N   1 
ATOM   3804 C  CA  . THR B 1 201 ? 7.78194   -16.59356 -11.82880 1.000 38.58071 ? 201 THR B CA  1 
ATOM   3805 C  C   . THR B 1 201 ? 6.26981   -16.77998 -11.84562 1.000 35.79204 ? 201 THR B C   1 
ATOM   3806 O  O   . THR B 1 201 ? 5.67585   -16.97597 -12.91259 1.000 32.59947 ? 201 THR B O   1 
ATOM   3807 C  CB  . THR B 1 201 ? 8.46858   -17.88350 -11.37860 1.000 36.36087 ? 201 THR B CB  1 
ATOM   3808 O  OG1 . THR B 1 201 ? 9.88213   -17.67175 -11.30710 1.000 35.95002 ? 201 THR B OG1 1 
ATOM   3809 C  CG2 . THR B 1 201 ? 8.17934   -19.00398 -12.36116 1.000 36.92613 ? 201 THR B CG2 1 
ATOM   3810 N  N   . VAL B 1 202 ? 5.62921   -16.73157 -10.67426 1.000 32.45290 ? 202 VAL B N   1 
ATOM   3811 C  CA  . VAL B 1 202 ? 4.18829   -16.96137 -10.60874 1.000 31.25264 ? 202 VAL B CA  1 
ATOM   3812 C  C   . VAL B 1 202 ? 3.43013   -15.89612 -11.39269 1.000 35.19354 ? 202 VAL B C   1 
ATOM   3813 O  O   . VAL B 1 202 ? 2.36317   -16.16976 -11.95794 1.000 27.24342 ? 202 VAL B O   1 
ATOM   3814 C  CB  . VAL B 1 202 ? 3.72915   -17.02904 -9.13773  1.000 29.29861 ? 202 VAL B CB  1 
ATOM   3815 C  CG1 . VAL B 1 202 ? 4.04448   -15.72727 -8.41435  1.000 32.33216 ? 202 VAL B CG1 1 
ATOM   3816 C  CG2 . VAL B 1 202 ? 2.23963   -17.35763 -9.05305  1.000 35.63688 ? 202 VAL B CG2 1 
ATOM   3817 N  N   . ASN B 1 203 ? 3.97075   -14.67728 -11.46045 1.000 30.52834 ? 203 ASN B N   1 
ATOM   3818 C  CA  . ASN B 1 203 ? 3.30849   -13.61697 -12.21222 1.000 33.29015 ? 203 ASN B CA  1 
ATOM   3819 C  C   . ASN B 1 203 ? 3.43132   -13.84173 -13.71403 1.000 30.26236 ? 203 ASN B C   1 
ATOM   3820 O  O   . ASN B 1 203 ? 2.48030   -13.59075 -14.46208 1.000 27.18590 ? 203 ASN B O   1 
ATOM   3821 C  CB  . ASN B 1 203 ? 3.88612   -12.25797 -11.81982 1.000 35.45014 ? 203 ASN B CB  1 
ATOM   3822 C  CG  . ASN B 1 203 ? 3.36389   -11.76818 -10.48202 1.000 33.51072 ? 203 ASN B CG  1 
ATOM   3823 O  OD1 . ASN B 1 203 ? 2.68992   -12.50238 -9.76043  1.000 30.39302 ? 203 ASN B OD1 1 
ATOM   3824 N  ND2 . ASN B 1 203 ? 3.67448   -10.52205 -10.14451 1.000 31.54463 ? 203 ASN B ND2 1 
ATOM   3825 N  N   . VAL B 1 204 ? 4.59574   -14.30762 -14.17419 1.000 36.06490 ? 204 VAL B N   1 
ATOM   3826 C  CA  . VAL B 1 204 ? 4.76287   -14.62663 -15.58984 1.000 33.29323 ? 204 VAL B CA  1 
ATOM   3827 C  C   . VAL B 1 204 ? 3.76412   -15.69532 -16.01135 1.000 33.94283 ? 204 VAL B C   1 
ATOM   3828 O  O   . VAL B 1 204 ? 3.14533   -15.60496 -17.07903 1.000 32.62900 ? 204 VAL B O   1 
ATOM   3829 C  CB  . VAL B 1 204 ? 6.21135   -15.06807 -15.87469 1.000 34.98877 ? 204 VAL B CB  1 
ATOM   3830 C  CG1 . VAL B 1 204 ? 6.36481   -15.48008 -17.33360 1.000 30.49615 ? 204 VAL B CG1 1 
ATOM   3831 C  CG2 . VAL B 1 204 ? 7.18652   -13.96091 -15.52800 1.000 25.01134 ? 204 VAL B CG2 1 
ATOM   3832 N  N   . LEU B 1 205 ? 3.58554   -16.71933 -15.17395 1.000 31.48845 ? 205 LEU B N   1 
ATOM   3833 C  CA  . LEU B 1 205 ? 2.65823   -17.79556 -15.50211 1.000 33.82321 ? 205 LEU B CA  1 
ATOM   3834 C  C   . LEU B 1 205 ? 1.22775   -17.28237 -15.58841 1.000 37.48281 ? 205 LEU B C   1 
ATOM   3835 O  O   . LEU B 1 205 ? 0.49013   -17.64026 -16.51354 1.000 36.74805 ? 205 LEU B O   1 
ATOM   3836 C  CB  . LEU B 1 205 ? 2.77284   -18.91228 -14.46578 1.000 29.76323 ? 205 LEU B CB  1 
ATOM   3837 C  CG  . LEU B 1 205 ? 4.15827   -19.56215 -14.39887 1.000 35.49022 ? 205 LEU B CG  1 
ATOM   3838 C  CD1 . LEU B 1 205 ? 4.27323   -20.49441 -13.20420 1.000 35.59020 ? 205 LEU B CD1 1 
ATOM   3839 C  CD2 . LEU B 1 205 ? 4.45110   -20.30880 -15.68878 1.000 35.62199 ? 205 LEU B CD2 1 
ATOM   3840 N  N   . ALA B 1 206 ? 0.81855   -16.44257 -14.63364 1.000 36.29115 ? 206 ALA B N   1 
ATOM   3841 C  CA  . ALA B 1 206 ? -0.50975  -15.84347 -14.69873 1.000 36.18248 ? 206 ALA B CA  1 
ATOM   3842 C  C   . ALA B 1 206 ? -0.66062  -14.98795 -15.94808 1.000 35.56981 ? 206 ALA B C   1 
ATOM   3843 O  O   . ALA B 1 206 ? -1.72648  -14.97003 -16.57474 1.000 33.36484 ? 206 ALA B O   1 
ATOM   3844 C  CB  . ALA B 1 206 ? -0.77112  -15.01403 -13.44379 1.000 33.30720 ? 206 ALA B CB  1 
ATOM   3845 N  N   . TRP B 1 207 ? 0.40357   -14.27802 -16.32775 1.000 31.19288 ? 207 TRP B N   1 
ATOM   3846 C  CA  . TRP B 1 207 ? 0.36717   -13.45929 -17.53329 1.000 30.63875 ? 207 TRP B CA  1 
ATOM   3847 C  C   . TRP B 1 207 ? 0.22693   -14.32121 -18.78236 1.000 36.72593 ? 207 TRP B C   1 
ATOM   3848 O  O   . TRP B 1 207 ? -0.50249  -13.95889 -19.71401 1.000 29.55538 ? 207 TRP B O   1 
ATOM   3849 C  CB  . TRP B 1 207 ? 1.62515   -12.59335 -17.60111 1.000 30.95686 ? 207 TRP B CB  1 
ATOM   3850 C  CG  . TRP B 1 207 ? 1.76209   -11.77457 -18.84928 1.000 35.91961 ? 207 TRP B CG  1 
ATOM   3851 C  CD1 . TRP B 1 207 ? 1.01837   -10.68555 -19.20559 1.000 33.77235 ? 207 TRP B CD1 1 
ATOM   3852 C  CD2 . TRP B 1 207 ? 2.72269   -11.96278 -19.89285 1.000 31.26171 ? 207 TRP B CD2 1 
ATOM   3853 N  NE1 . TRP B 1 207 ? 1.45088   -10.19234 -20.41331 1.000 31.90357 ? 207 TRP B NE1 1 
ATOM   3854 C  CE2 . TRP B 1 207 ? 2.49593   -10.95974 -20.85636 1.000 33.10749 ? 207 TRP B CE2 1 
ATOM   3855 C  CE3 . TRP B 1 207 ? 3.74737   -12.88726 -20.11032 1.000 32.01331 ? 207 TRP B CE3 1 
ATOM   3856 C  CZ2 . TRP B 1 207 ? 3.25717   -10.85513 -22.01595 1.000 33.51243 ? 207 TRP B CZ2 1 
ATOM   3857 C  CZ3 . TRP B 1 207 ? 4.50143   -12.78098 -21.26313 1.000 36.72178 ? 207 TRP B CZ3 1 
ATOM   3858 C  CH2 . TRP B 1 207 ? 4.25316   -11.77262 -22.20108 1.000 30.81251 ? 207 TRP B CH2 1 
ATOM   3859 N  N   . LEU B 1 208 ? 0.91513   -15.46668 -18.81942 1.000 32.73112 ? 208 LEU B N   1 
ATOM   3860 C  CA  . LEU B 1 208 ? 0.75560   -16.38691 -19.94043 1.000 32.55369 ? 208 LEU B CA  1 
ATOM   3861 C  C   . LEU B 1 208 ? -0.65698  -16.94959 -19.99659 1.000 32.68064 ? 208 LEU B C   1 
ATOM   3862 O  O   . LEU B 1 208 ? -1.17776  -17.21235 -21.08681 1.000 32.86040 ? 208 LEU B O   1 
ATOM   3863 C  CB  . LEU B 1 208 ? 1.77556   -17.52368 -19.84601 1.000 28.83184 ? 208 LEU B CB  1 
ATOM   3864 C  CG  . LEU B 1 208 ? 3.25281   -17.14416 -19.96541 1.000 33.62459 ? 208 LEU B CG  1 
ATOM   3865 C  CD1 . LEU B 1 208 ? 4.13475   -18.34531 -19.66800 1.000 35.30206 ? 208 LEU B CD1 1 
ATOM   3866 C  CD2 . LEU B 1 208 ? 3.56756   -16.58029 -21.34545 1.000 31.46598 ? 208 LEU B CD2 1 
ATOM   3867 N  N   . TYR B 1 209 ? -1.28905  -17.14616 -18.83706 1.000 31.42746 ? 209 TYR B N   1 
ATOM   3868 C  CA  . TYR B 1 209 ? -2.68579  -17.56881 -18.82392 1.000 37.24594 ? 209 TYR B CA  1 
ATOM   3869 C  C   . TYR B 1 209 ? -3.59099  -16.48817 -19.39884 1.000 38.95038 ? 209 TYR B C   1 
ATOM   3870 O  O   . TYR B 1 209 ? -4.52672  -16.78802 -20.14958 1.000 36.15357 ? 209 TYR B O   1 
ATOM   3871 C  CB  . TYR B 1 209 ? -3.11958  -17.93163 -17.40464 1.000 32.13610 ? 209 TYR B CB  1 
ATOM   3872 C  CG  . TYR B 1 209 ? -2.77364  -19.34734 -17.00553 1.000 40.49210 ? 209 TYR B CG  1 
ATOM   3873 C  CD1 . TYR B 1 209 ? -3.39296  -20.43115 -17.61579 1.000 42.49436 ? 209 TYR B CD1 1 
ATOM   3874 C  CD2 . TYR B 1 209 ? -1.83793  -19.60227 -16.01250 1.000 40.01327 ? 209 TYR B CD2 1 
ATOM   3875 C  CE1 . TYR B 1 209 ? -3.08305  -21.73028 -17.25372 1.000 45.52687 ? 209 TYR B CE1 1 
ATOM   3876 C  CE2 . TYR B 1 209 ? -1.52116  -20.89843 -15.64350 1.000 47.53626 ? 209 TYR B CE2 1 
ATOM   3877 C  CZ  . TYR B 1 209 ? -2.14693  -21.95864 -16.26695 1.000 47.29856 ? 209 TYR B CZ  1 
ATOM   3878 O  OH  . TYR B 1 209 ? -1.83505  -23.24952 -15.90437 1.000 44.24020 ? 209 TYR B OH  1 
ATOM   3879 N  N   . ALA B 1 210 ? -3.32829  -15.22315 -19.05610 1.000 36.31483 ? 210 ALA B N   1 
ATOM   3880 C  CA  . ALA B 1 210 ? -4.08355  -14.12548 -19.64892 1.000 33.03144 ? 210 ALA B CA  1 
ATOM   3881 C  C   . ALA B 1 210 ? -3.88880  -14.07117 -21.15687 1.000 38.19630 ? 210 ALA B C   1 
ATOM   3882 O  O   . ALA B 1 210 ? -4.80768  -13.68768 -21.88866 1.000 38.43506 ? 210 ALA B O   1 
ATOM   3883 C  CB  . ALA B 1 210 ? -3.67329  -12.79782 -19.01144 1.000 32.41106 ? 210 ALA B CB  1 
ATOM   3884 N  N   . ALA B 1 211 ? -2.70387  -14.45126 -21.63868 1.000 35.17866 ? 211 ALA B N   1 
ATOM   3885 C  CA  . ALA B 1 211 ? -2.47165  -14.50436 -23.07670 1.000 35.74339 ? 211 ALA B CA  1 
ATOM   3886 C  C   . ALA B 1 211 ? -3.33382  -15.57876 -23.72692 1.000 39.53894 ? 211 ALA B C   1 
ATOM   3887 O  O   . ALA B 1 211 ? -3.96086  -15.34443 -24.76709 1.000 39.28775 ? 211 ALA B O   1 
ATOM   3888 C  CB  . ALA B 1 211 ? -0.99131  -14.75665 -23.35552 1.000 33.81553 ? 211 ALA B CB  1 
ATOM   3889 N  N   . VAL B 1 212 ? -3.36997  -16.77042 -23.12457 1.000 34.00547 ? 212 VAL B N   1 
ATOM   3890 C  CA  . VAL B 1 212 ? -4.20770  -17.85211 -23.63885 1.000 42.64292 ? 212 VAL B CA  1 
ATOM   3891 C  C   . VAL B 1 212 ? -5.66447  -17.40932 -23.69715 1.000 41.13072 ? 212 VAL B C   1 
ATOM   3892 O  O   . VAL B 1 212 ? -6.36267  -17.62923 -24.69453 1.000 41.56907 ? 212 VAL B O   1 
ATOM   3893 C  CB  . VAL B 1 212 ? -4.03913  -19.11523 -22.77373 1.000 37.49646 ? 212 VAL B CB  1 
ATOM   3894 C  CG1 . VAL B 1 212 ? -5.02133  -20.19459 -23.20647 1.000 34.11215 ? 212 VAL B CG1 1 
ATOM   3895 C  CG2 . VAL B 1 212 ? -2.60792  -19.62614 -22.84971 1.000 37.11096 ? 212 VAL B CG2 1 
ATOM   3896 N  N   . ILE B 1 213 ? -6.13877  -16.76644 -22.62624 1.000 41.10099 ? 213 ILE B N   1 
ATOM   3897 C  CA  . ILE B 1 213 ? -7.52409  -16.30848 -22.55698 1.000 38.55832 ? 213 ILE B CA  1 
ATOM   3898 C  C   . ILE B 1 213 ? -7.84364  -15.34893 -23.69416 1.000 40.31638 ? 213 ILE B C   1 
ATOM   3899 O  O   . ILE B 1 213 ? -8.97070  -15.32447 -24.20299 1.000 43.81011 ? 213 ILE B O   1 
ATOM   3900 C  CB  . ILE B 1 213 ? -7.78985  -15.66888 -21.17787 1.000 40.35225 ? 213 ILE B CB  1 
ATOM   3901 C  CG1 . ILE B 1 213 ? -7.69782  -16.72558 -20.07219 1.000 43.79302 ? 213 ILE B CG1 1 
ATOM   3902 C  CG2 . ILE B 1 213 ? -9.14674  -14.98176 -21.14318 1.000 42.83105 ? 213 ILE B CG2 1 
ATOM   3903 C  CD1 . ILE B 1 213 ? -7.83354  -16.15917 -18.67494 1.000 38.57200 ? 213 ILE B CD1 1 
ATOM   3904 N  N   . ASN B 1 214 ? -6.86108  -14.56651 -24.13085 1.000 41.90801 ? 214 ASN B N   1 
ATOM   3905 C  CA  . ASN B 1 214 ? -7.05975  -13.57734 -25.18031 1.000 41.47502 ? 214 ASN B CA  1 
ATOM   3906 C  C   . ASN B 1 214 ? -6.66540  -14.07774 -26.56603 1.000 42.81128 ? 214 ASN B C   1 
ATOM   3907 O  O   . ASN B 1 214 ? -6.63768  -13.28242 -27.50953 1.000 47.20198 ? 214 ASN B O   1 
ATOM   3908 C  CB  . ASN B 1 214 ? -6.28953  -12.29850 -24.85015 1.000 37.95121 ? 214 ASN B CB  1 
ATOM   3909 C  CG  . ASN B 1 214 ? -7.01123  -11.43326 -23.83806 1.000 41.63815 ? 214 ASN B CG  1 
ATOM   3910 O  OD1 . ASN B 1 214 ? -7.90837  -10.66665 -24.19046 1.000 38.75165 ? 214 ASN B OD1 1 
ATOM   3911 N  ND2 . ASN B 1 214 ? -6.62078  -11.54640 -22.57288 1.000 42.91402 ? 214 ASN B ND2 1 
ATOM   3912 N  N   . GLY B 1 215 ? -6.35240  -15.36632 -26.71314 1.000 41.64579 ? 215 GLY B N   1 
ATOM   3913 C  CA  . GLY B 1 215 ? -6.14582  -15.96776 -28.01479 1.000 33.21092 ? 215 GLY B CA  1 
ATOM   3914 C  C   . GLY B 1 215 ? -4.70294  -16.16978 -28.43262 1.000 49.59137 ? 215 GLY B C   1 
ATOM   3915 O  O   . GLY B 1 215 ? -4.46445  -16.79913 -29.47067 1.000 48.30952 ? 215 GLY B O   1 
ATOM   3916 N  N   . ASP B 1 216 ? -3.73744  -15.65028 -27.67913 1.000 43.87349 ? 216 ASP B N   1 
ATOM   3917 C  CA  . ASP B 1 216 ? -2.32452  -15.88431 -27.97665 1.000 38.76105 ? 216 ASP B CA  1 
ATOM   3918 C  C   . ASP B 1 216 ? -1.94719  -17.24662 -27.40934 1.000 46.60134 ? 216 ASP B C   1 
ATOM   3919 O  O   . ASP B 1 216 ? -1.78299  -17.40311 -26.19795 1.000 47.26291 ? 216 ASP B O   1 
ATOM   3920 C  CB  . ASP B 1 216 ? -1.45728  -14.77514 -27.39262 1.000 45.39094 ? 216 ASP B CB  1 
ATOM   3921 C  CG  . ASP B 1 216 ? -0.92671  -13.83134 -28.45025 1.000 50.60845 ? 216 ASP B CG  1 
ATOM   3922 O  OD1 . ASP B 1 216 ? -0.80808  -14.25296 -29.62174 1.000 70.72073 ? 216 ASP B OD1 1 
ATOM   3923 O  OD2 . ASP B 1 216 ? -0.62304  -12.66756 -28.11001 1.000 55.48363 ? 216 ASP B OD2 1 
ATOM   3924 N  N   . ARG B 1 217 ? -1.81614  -18.24646 -28.28642 1.000 41.46415 ? 217 ARG B N   1 
ATOM   3925 C  CA  . ARG B 1 217 ? -1.63093  -19.62760 -27.85600 1.000 45.36027 ? 217 ARG B CA  1 
ATOM   3926 C  C   . ARG B 1 217 ? -0.45394  -20.32484 -28.53079 1.000 47.35387 ? 217 ARG B C   1 
ATOM   3927 O  O   . ARG B 1 217 ? -0.30503  -21.54309 -28.37274 1.000 48.94015 ? 217 ARG B O   1 
ATOM   3928 C  CB  . ARG B 1 217 ? -2.90669  -20.44471 -28.10778 1.000 48.57429 ? 217 ARG B CB  1 
ATOM   3929 C  CG  . ARG B 1 217 ? -4.15553  -19.89860 -27.43276 1.000 49.69570 ? 217 ARG B CG  1 
ATOM   3930 C  CD  . ARG B 1 217 ? -5.40286  -20.67230 -27.84903 1.000 52.19440 ? 217 ARG B CD  1 
ATOM   3931 N  NE  . ARG B 1 217 ? -5.89284  -21.55413 -26.79556 1.000 66.08436 ? 217 ARG B NE  1 
ATOM   3932 C  CZ  . ARG B 1 217 ? -5.57079  -22.83483 -26.67932 1.000 59.77476 ? 217 ARG B CZ  1 
ATOM   3933 N  NH1 . ARG B 1 217 ? -4.74759  -23.41974 -27.53319 1.000 62.72466 ? 217 ARG B NH1 1 
ATOM   3934 N  NH2 . ARG B 1 217 ? -6.08789  -23.54611 -25.68126 1.000 57.08462 ? 217 ARG B NH2 1 
ATOM   3935 N  N   . TRP B 1 218 ? 0.38904   -19.59873 -29.27052 1.000 47.01532 ? 218 TRP B N   1 
ATOM   3936 C  CA  . TRP B 1 218 ? 1.45569   -20.26171 -30.01553 1.000 44.61924 ? 218 TRP B CA  1 
ATOM   3937 C  C   . TRP B 1 218 ? 2.48711   -20.90175 -29.09284 1.000 52.59723 ? 218 TRP B C   1 
ATOM   3938 O  O   . TRP B 1 218 ? 3.10867   -21.90271 -29.46556 1.000 51.20553 ? 218 TRP B O   1 
ATOM   3939 C  CB  . TRP B 1 218 ? 2.13583   -19.27283 -30.96452 1.000 43.66050 ? 218 TRP B CB  1 
ATOM   3940 C  CG  . TRP B 1 218 ? 2.84070   -18.14228 -30.27616 1.000 49.06874 ? 218 TRP B CG  1 
ATOM   3941 C  CD1 . TRP B 1 218 ? 2.34151   -16.89727 -30.02914 1.000 51.98754 ? 218 TRP B CD1 1 
ATOM   3942 C  CD2 . TRP B 1 218 ? 4.17611   -18.15000 -29.75167 1.000 48.82569 ? 218 TRP B CD2 1 
ATOM   3943 N  NE1 . TRP B 1 218 ? 3.27999   -16.12952 -29.38311 1.000 45.77570 ? 218 TRP B NE1 1 
ATOM   3944 C  CE2 . TRP B 1 218 ? 4.41500   -16.87510 -29.20081 1.000 50.74654 ? 218 TRP B CE2 1 
ATOM   3945 C  CE3 . TRP B 1 218 ? 5.19240   -19.10987 -29.69624 1.000 49.67248 ? 218 TRP B CE3 1 
ATOM   3946 C  CZ2 . TRP B 1 218 ? 5.62654   -16.53570 -28.60012 1.000 50.11830 ? 218 TRP B CZ2 1 
ATOM   3947 C  CZ3 . TRP B 1 218 ? 6.39372   -18.77234 -29.09690 1.000 55.69168 ? 218 TRP B CZ3 1 
ATOM   3948 C  CH2 . TRP B 1 218 ? 6.60073   -17.49572 -28.55741 1.000 56.92884 ? 218 TRP B CH2 1 
ATOM   3949 N  N   . PHE B 1 219 ? 2.68197   -20.35036 -27.89364 1.000 52.03379 ? 219 PHE B N   1 
ATOM   3950 C  CA  . PHE B 1 219 ? 3.71935   -20.83245 -26.98843 1.000 47.98461 ? 219 PHE B CA  1 
ATOM   3951 C  C   . PHE B 1 219 ? 3.33486   -22.10996 -26.25254 1.000 45.11812 ? 219 PHE B C   1 
ATOM   3952 O  O   . PHE B 1 219 ? 4.19008   -22.69549 -25.57894 1.000 47.56356 ? 219 PHE B O   1 
ATOM   3953 C  CB  . PHE B 1 219 ? 4.07354   -19.74239 -25.97236 1.000 45.80673 ? 219 PHE B CB  1 
ATOM   3954 C  CG  . PHE B 1 219 ? 2.87995   -19.16802 -25.26002 1.000 47.01347 ? 219 PHE B CG  1 
ATOM   3955 C  CD1 . PHE B 1 219 ? 2.38435   -19.76704 -24.11192 1.000 44.67212 ? 219 PHE B CD1 1 
ATOM   3956 C  CD2 . PHE B 1 219 ? 2.24983   -18.03011 -25.74166 1.000 42.37423 ? 219 PHE B CD2 1 
ATOM   3957 C  CE1 . PHE B 1 219 ? 1.28098   -19.24259 -23.45701 1.000 43.38424 ? 219 PHE B CE1 1 
ATOM   3958 C  CE2 . PHE B 1 219 ? 1.14873   -17.50104 -25.09073 1.000 42.82125 ? 219 PHE B CE2 1 
ATOM   3959 C  CZ  . PHE B 1 219 ? 0.66348   -18.10787 -23.94782 1.000 37.53713 ? 219 PHE B CZ  1 
ATOM   3960 N  N   . LEU B 1 220 ? 2.08522   -22.55261 -26.35516 1.000 44.94495 ? 220 LEU B N   1 
ATOM   3961 C  CA  . LEU B 1 220 ? 1.67374   -23.77071 -25.67643 1.000 55.65873 ? 220 LEU B CA  1 
ATOM   3962 C  C   . LEU B 1 220 ? 2.32449   -24.99259 -26.32136 1.000 57.31208 ? 220 LEU B C   1 
ATOM   3963 O  O   . LEU B 1 220 ? 2.78120   -24.95846 -27.46792 1.000 59.76461 ? 220 LEU B O   1 
ATOM   3964 C  CB  . LEU B 1 220 ? 0.15163   -23.91498 -25.70170 1.000 45.85950 ? 220 LEU B CB  1 
ATOM   3965 C  CG  . LEU B 1 220 ? -0.65437  -22.83283 -24.98108 1.000 50.08564 ? 220 LEU B CG  1 
ATOM   3966 C  CD1 . LEU B 1 220 ? -2.13601  -23.17500 -24.98995 1.000 45.02232 ? 220 LEU B CD1 1 
ATOM   3967 C  CD2 . LEU B 1 220 ? -0.15358  -22.64269 -23.55827 1.000 47.68644 ? 220 LEU B CD2 1 
ATOM   3968 N  N   . ASN B 1 221 ? 2.36736   -26.08454 -25.56059 1.000 57.05910 ? 221 ASN B N   1 
ATOM   3969 C  CA  . ASN B 1 221 ? 2.89590   -27.34787 -26.05564 1.000 57.43701 ? 221 ASN B CA  1 
ATOM   3970 C  C   . ASN B 1 221 ? 2.15529   -28.49193 -25.37345 1.000 62.26974 ? 221 ASN B C   1 
ATOM   3971 O  O   . ASN B 1 221 ? 1.28072   -28.27899 -24.52858 1.000 67.43809 ? 221 ASN B O   1 
ATOM   3972 C  CB  . ASN B 1 221 ? 4.41181   -27.44300 -25.83829 1.000 62.26970 ? 221 ASN B CB  1 
ATOM   3973 C  CG  . ASN B 1 221 ? 4.81181   -27.33754 -24.37361 1.000 55.99389 ? 221 ASN B CG  1 
ATOM   3974 O  OD1 . ASN B 1 221 ? 3.96948   -27.34806 -23.47472 1.000 62.63834 ? 221 ASN B OD1 1 
ATOM   3975 N  ND2 . ASN B 1 221 ? 6.11361   -27.24323 -24.13016 1.000 57.63528 ? 221 ASN B ND2 1 
ATOM   3976 N  N   . ARG B 1 222 ? 2.51790   -29.71621 -25.74529 1.000 64.79483 ? 222 ARG B N   1 
ATOM   3977 C  CA  . ARG B 1 222 ? 1.90536   -30.91261 -25.18498 1.000 64.87978 ? 222 ARG B CA  1 
ATOM   3978 C  C   . ARG B 1 222 ? 2.68582   -31.48274 -24.00905 1.000 59.34796 ? 222 ARG B C   1 
ATOM   3979 O  O   . ARG B 1 222 ? 2.27716   -32.50496 -23.44868 1.000 65.17200 ? 222 ARG B O   1 
ATOM   3980 C  CB  . ARG B 1 222 ? 1.75947   -31.98546 -26.27044 1.000 60.20085 ? 222 ARG B CB  1 
ATOM   3981 N  N   . PHE B 1 223 ? 3.78013   -30.84669 -23.61376 1.000 54.61138 ? 223 PHE B N   1 
ATOM   3982 C  CA  . PHE B 1 223 ? 4.70147   -31.42202 -22.64877 1.000 60.45924 ? 223 PHE B CA  1 
ATOM   3983 C  C   . PHE B 1 223 ? 4.45135   -30.88943 -21.24445 1.000 70.25319 ? 223 PHE B C   1 
ATOM   3984 O  O   . PHE B 1 223 ? 3.81231   -29.85334 -21.04185 1.000 74.08351 ? 223 PHE B O   1 
ATOM   3985 C  CB  . PHE B 1 223 ? 6.14737   -31.14441 -23.05910 1.000 52.65063 ? 223 PHE B CB  1 
ATOM   3986 C  CG  . PHE B 1 223 ? 6.50980   -31.71571 -24.39505 1.000 57.21617 ? 223 PHE B CG  1 
ATOM   3987 C  CD1 . PHE B 1 223 ? 6.44690   -33.08177 -24.61511 1.000 48.30259 ? 223 PHE B CD1 1 
ATOM   3988 C  CD2 . PHE B 1 223 ? 6.91474   -30.89135 -25.43041 1.000 56.00497 ? 223 PHE B CD2 1 
ATOM   3989 C  CE1 . PHE B 1 223 ? 6.77811   -33.61462 -25.84336 1.000 44.79266 ? 223 PHE B CE1 1 
ATOM   3990 C  CE2 . PHE B 1 223 ? 7.24912   -31.41911 -26.66180 1.000 56.32383 ? 223 PHE B CE2 1 
ATOM   3991 C  CZ  . PHE B 1 223 ? 7.17988   -32.78302 -26.86818 1.000 49.38432 ? 223 PHE B CZ  1 
ATOM   3992 N  N   . THR B 1 224 ? 4.97273   -31.63030 -20.27039 1.000 63.78097 ? 224 THR B N   1 
ATOM   3993 C  CA  . THR B 1 224 ? 4.91965   -31.26456 -18.86604 1.000 58.46067 ? 224 THR B CA  1 
ATOM   3994 C  C   . THR B 1 224 ? 6.31598   -31.39328 -18.27597 1.000 57.48789 ? 224 THR B C   1 
ATOM   3995 O  O   . THR B 1 224 ? 7.11532   -32.22949 -18.70700 1.000 61.56189 ? 224 THR B O   1 
ATOM   3996 C  CB  . THR B 1 224 ? 3.93718   -32.15623 -18.08826 1.000 56.39313 ? 224 THR B CB  1 
ATOM   3997 O  OG1 . THR B 1 224 ? 2.73432   -32.31735 -18.84843 1.000 70.12000 ? 224 THR B OG1 1 
ATOM   3998 C  CG2 . THR B 1 224 ? 3.59107   -31.53803 -16.74452 1.000 52.81779 ? 224 THR B CG2 1 
ATOM   3999 N  N   . THR B 1 225 ? 6.61092   -30.54556 -17.30208 1.000 52.68390 ? 225 THR B N   1 
ATOM   4000 C  CA  . THR B 1 225 ? 7.83692   -30.63437 -16.52594 1.000 49.18987 ? 225 THR B CA  1 
ATOM   4001 C  C   . THR B 1 225 ? 7.47400   -30.95089 -15.08021 1.000 54.49210 ? 225 THR B C   1 
ATOM   4002 O  O   . THR B 1 225 ? 6.30397   -31.14157 -14.73864 1.000 52.36158 ? 225 THR B O   1 
ATOM   4003 C  CB  . THR B 1 225 ? 8.64862   -29.33787 -16.62211 1.000 50.90531 ? 225 THR B CB  1 
ATOM   4004 O  OG1 . THR B 1 225 ? 9.91438   -29.51024 -15.97173 1.000 54.51361 ? 225 THR B OG1 1 
ATOM   4005 C  CG2 . THR B 1 225 ? 7.90152   -28.19243 -15.95999 1.000 52.69982 ? 225 THR B CG2 1 
ATOM   4006 N  N   . THR B 1 226 ? 8.49097   -31.02147 -14.23023 1.000 47.52836 ? 226 THR B N   1 
ATOM   4007 C  CA  . THR B 1 226 ? 8.29227   -31.15208 -12.79716 1.000 53.70018 ? 226 THR B CA  1 
ATOM   4008 C  C   . THR B 1 226 ? 8.71476   -29.86071 -12.11142 1.000 52.10958 ? 226 THR B C   1 
ATOM   4009 O  O   . THR B 1 226 ? 9.49628   -29.07147 -12.65165 1.000 51.18798 ? 226 THR B O   1 
ATOM   4010 C  CB  . THR B 1 226 ? 9.07890   -32.33803 -12.22296 1.000 49.53555 ? 226 THR B CB  1 
ATOM   4011 O  OG1 . THR B 1 226 ? 10.48474  -32.09668 -12.35458 1.000 50.18773 ? 226 THR B OG1 1 
ATOM   4012 C  CG2 . THR B 1 226 ? 8.72100   -33.61804 -12.95776 1.000 54.13086 ? 226 THR B CG2 1 
ATOM   4013 N  N   . LEU B 1 227 ? 8.17375   -29.64669 -10.90927 1.000 51.89460 ? 227 LEU B N   1 
ATOM   4014 C  CA  . LEU B 1 227 ? 8.52312   -28.44920 -10.15442 1.000 46.35260 ? 227 LEU B CA  1 
ATOM   4015 C  C   . LEU B 1 227 ? 10.01294  -28.40168 -9.85233  1.000 47.74597 ? 227 LEU B C   1 
ATOM   4016 O  O   . LEU B 1 227 ? 10.59613  -27.31464 -9.77323  1.000 53.46209 ? 227 LEU B O   1 
ATOM   4017 C  CB  . LEU B 1 227 ? 7.70919   -28.38713 -8.86335  1.000 46.32199 ? 227 LEU B CB  1 
ATOM   4018 C  CG  . LEU B 1 227 ? 7.51858   -26.99183 -8.26627  1.000 55.82684 ? 227 LEU B CG  1 
ATOM   4019 C  CD1 . LEU B 1 227 ? 6.99133   -26.03797 -9.32626  1.000 44.68052 ? 227 LEU B CD1 1 
ATOM   4020 C  CD2 . LEU B 1 227 ? 6.57416   -27.04240 -7.07505  1.000 49.09403 ? 227 LEU B CD2 1 
ATOM   4021 N  N   . ASN B 1 228 ? 10.64716  -29.56615 -9.70085  1.000 51.54058 ? 228 ASN B N   1 
ATOM   4022 C  CA  . ASN B 1 228 ? 12.08816  -29.61480 -9.47575  1.000 52.51875 ? 228 ASN B CA  1 
ATOM   4023 C  C   . ASN B 1 228 ? 12.86316  -29.34043 -10.75913 1.000 50.09232 ? 228 ASN B C   1 
ATOM   4024 O  O   . ASN B 1 228 ? 13.82733  -28.56761 -10.75542 1.000 46.64650 ? 228 ASN B O   1 
ATOM   4025 C  CB  . ASN B 1 228 ? 12.48584  -30.97191 -8.89070  1.000 52.21145 ? 228 ASN B CB  1 
ATOM   4026 C  CG  . ASN B 1 228 ? 12.78805  -30.90070 -7.40905  1.000 57.81404 ? 228 ASN B CG  1 
ATOM   4027 O  OD1 . ASN B 1 228 ? 11.90690  -31.10041 -6.57216  1.000 61.64761 ? 228 ASN B OD1 1 
ATOM   4028 N  ND2 . ASN B 1 228 ? 14.04188  -30.61162 -7.07582  1.000 67.91204 ? 228 ASN B ND2 1 
ATOM   4029 N  N   . ASP B 1 229 ? 12.46267  -29.97353 -11.86539 1.000 54.67557 ? 229 ASP B N   1 
ATOM   4030 C  CA  . ASP B 1 229 ? 13.12715  -29.71829 -13.14034 1.000 51.72045 ? 229 ASP B CA  1 
ATOM   4031 C  C   . ASP B 1 229 ? 12.97602  -28.26172 -13.55436 1.000 49.94815 ? 229 ASP B C   1 
ATOM   4032 O  O   . ASP B 1 229 ? 13.90618  -27.66611 -14.11115 1.000 48.71159 ? 229 ASP B O   1 
ATOM   4033 C  CB  . ASP B 1 229 ? 12.57135  -30.63977 -14.22899 1.000 52.35885 ? 229 ASP B CB  1 
ATOM   4034 C  CG  . ASP B 1 229 ? 13.09066  -32.06042 -14.11688 1.000 49.82693 ? 229 ASP B CG  1 
ATOM   4035 O  OD1 . ASP B 1 229 ? 14.21925  -32.24239 -13.61650 1.000 57.21749 ? 229 ASP B OD1 1 
ATOM   4036 O  OD2 . ASP B 1 229 ? 12.37360  -32.99545 -14.53373 1.000 58.63013 ? 229 ASP B OD2 1 
ATOM   4037 N  N   . PHE B 1 230 ? 11.81237  -27.66792 -13.28341 1.000 55.92737 ? 230 PHE B N   1 
ATOM   4038 C  CA  . PHE B 1 230 ? 11.58919  -26.28039 -13.67236 1.000 52.57214 ? 230 PHE B CA  1 
ATOM   4039 C  C   . PHE B 1 230 ? 12.42361  -25.32995 -12.82333 1.000 51.16855 ? 230 PHE B C   1 
ATOM   4040 O  O   . PHE B 1 230 ? 13.05427  -24.40465 -13.34803 1.000 48.27875 ? 230 PHE B O   1 
ATOM   4041 C  CB  . PHE B 1 230 ? 10.10476  -25.93053 -13.56851 1.000 48.87142 ? 230 PHE B CB  1 
ATOM   4042 C  CG  . PHE B 1 230 ? 9.80752   -24.49180 -13.87594 1.000 53.32202 ? 230 PHE B CG  1 
ATOM   4043 C  CD1 . PHE B 1 230 ? 9.80402   -24.03801 -15.18389 1.000 37.43905 ? 230 PHE B CD1 1 
ATOM   4044 C  CD2 . PHE B 1 230 ? 9.54907   -23.58892 -12.85716 1.000 53.18220 ? 230 PHE B CD2 1 
ATOM   4045 C  CE1 . PHE B 1 230 ? 9.54054   -22.71231 -15.47284 1.000 48.91295 ? 230 PHE B CE1 1 
ATOM   4046 C  CE2 . PHE B 1 230 ? 9.28432   -22.26140 -13.13925 1.000 51.79746 ? 230 PHE B CE2 1 
ATOM   4047 C  CZ  . PHE B 1 230 ? 9.27979   -21.82293 -14.44987 1.000 53.03684 ? 230 PHE B CZ  1 
ATOM   4048 N  N   . ASN B 1 231 ? 12.44226  -25.54397 -11.50521 1.000 54.20536 ? 231 ASN B N   1 
ATOM   4049 C  CA  . ASN B 1 231 ? 13.17806  -24.64176 -10.62561 1.000 48.88665 ? 231 ASN B CA  1 
ATOM   4050 C  C   . ASN B 1 231 ? 14.68265  -24.73050 -10.84932 1.000 50.99395 ? 231 ASN B C   1 
ATOM   4051 O  O   . ASN B 1 231 ? 15.40286  -23.75898 -10.58957 1.000 57.92583 ? 231 ASN B O   1 
ATOM   4052 C  CB  . ASN B 1 231 ? 12.83102  -24.93361 -9.16716  1.000 50.27516 ? 231 ASN B CB  1 
ATOM   4053 C  CG  . ASN B 1 231 ? 11.48589  -24.35821 -8.76476  1.000 53.06454 ? 231 ASN B CG  1 
ATOM   4054 O  OD1 . ASN B 1 231 ? 11.04769  -23.34157 -9.30516  1.000 49.41832 ? 231 ASN B OD1 1 
ATOM   4055 N  ND2 . ASN B 1 231 ? 10.82337  -25.00531 -7.81225  1.000 53.75451 ? 231 ASN B ND2 1 
ATOM   4056 N  N   . LEU B 1 232 ? 15.17637  -25.87703 -11.32530 1.000 53.19988 ? 232 LEU B N   1 
ATOM   4057 C  CA  . LEU B 1 232 ? 16.58406  -25.96874 -11.69628 1.000 48.75545 ? 232 LEU B CA  1 
ATOM   4058 C  C   . LEU B 1 232 ? 16.89185  -25.10362 -12.91155 1.000 53.01619 ? 232 LEU B C   1 
ATOM   4059 O  O   . LEU B 1 232 ? 17.98381  -24.53132 -13.00421 1.000 54.91101 ? 232 LEU B O   1 
ATOM   4060 C  CB  . LEU B 1 232 ? 16.96677  -27.42592 -11.96252 1.000 47.49478 ? 232 LEU B CB  1 
ATOM   4061 N  N   . VAL B 1 233 ? 15.94718  -24.99524 -13.84734 1.000 56.58244 ? 233 VAL B N   1 
ATOM   4062 C  CA  . VAL B 1 233 ? 16.13032  -24.11430 -14.99523 1.000 49.05189 ? 233 VAL B CA  1 
ATOM   4063 C  C   . VAL B 1 233 ? 15.88500  -22.66356 -14.60097 1.000 53.18458 ? 233 VAL B C   1 
ATOM   4064 O  O   . VAL B 1 233 ? 16.55392  -21.75119 -15.09850 1.000 57.16159 ? 233 VAL B O   1 
ATOM   4065 C  CB  . VAL B 1 233 ? 15.20960  -24.55336 -16.14897 1.000 60.62654 ? 233 VAL B CB  1 
ATOM   4066 C  CG1 . VAL B 1 233 ? 15.44892  -23.69141 -17.38121 1.000 64.01479 ? 233 VAL B CG1 1 
ATOM   4067 C  CG2 . VAL B 1 233 ? 15.42227  -26.02364 -16.46967 1.000 61.04619 ? 233 VAL B CG2 1 
ATOM   4068 N  N   . ALA B 1 234 ? 14.93211  -22.43117 -13.69405 1.000 57.93106 ? 234 ALA B N   1 
ATOM   4069 C  CA  . ALA B 1 234 ? 14.58531  -21.06870 -13.30225 1.000 56.91946 ? 234 ALA B CA  1 
ATOM   4070 C  C   . ALA B 1 234 ? 15.73784  -20.38404 -12.57728 1.000 59.76774 ? 234 ALA B C   1 
ATOM   4071 O  O   . ALA B 1 234 ? 16.00411  -19.19830 -12.80740 1.000 55.99502 ? 234 ALA B O   1 
ATOM   4072 C  CB  . ALA B 1 234 ? 13.33283  -21.08191 -12.42569 1.000 51.58647 ? 234 ALA B CB  1 
ATOM   4073 N  N   . MET B 1 235 ? 16.43362  -21.11334 -11.69924 1.000 53.67780 ? 235 MET B N   1 
ATOM   4074 C  CA  . MET B 1 235 ? 17.52661  -20.51449 -10.94030 1.000 50.53573 ? 235 MET B CA  1 
ATOM   4075 C  C   . MET B 1 235 ? 18.64356  -20.02147 -11.85126 1.000 53.14967 ? 235 MET B C   1 
ATOM   4076 O  O   . MET B 1 235 ? 19.35833  -19.07602 -11.49931 1.000 54.15540 ? 235 MET B O   1 
ATOM   4077 C  CB  . MET B 1 235 ? 18.07171  -21.52145 -9.92760  1.000 48.80600 ? 235 MET B CB  1 
ATOM   4078 N  N   . LYS B 1 236 ? 18.80361  -20.63805 -13.02461 1.000 53.75097 ? 236 LYS B N   1 
ATOM   4079 C  CA  . LYS B 1 236 ? 19.86104  -20.25152 -13.94996 1.000 52.03937 ? 236 LYS B CA  1 
ATOM   4080 C  C   . LYS B 1 236 ? 19.56969  -18.94015 -14.66814 1.000 54.76035 ? 236 LYS B C   1 
ATOM   4081 O  O   . LYS B 1 236 ? 20.51107  -18.26383 -15.09788 1.000 50.06512 ? 236 LYS B O   1 
ATOM   4082 C  CB  . LYS B 1 236 ? 20.08645  -21.35986 -14.98146 1.000 52.76280 ? 236 LYS B CB  1 
ATOM   4083 N  N   . TYR B 1 237 ? 18.29653  -18.56851 -14.81575 1.000 55.77279 ? 237 TYR B N   1 
ATOM   4084 C  CA  . TYR B 1 237 ? 17.91489  -17.33683 -15.49599 1.000 52.74188 ? 237 TYR B CA  1 
ATOM   4085 C  C   . TYR B 1 237 ? 17.45617  -16.25493 -14.52464 1.000 52.21968 ? 237 TYR B C   1 
ATOM   4086 O  O   . TYR B 1 237 ? 16.78252  -15.30543 -14.93759 1.000 47.29807 ? 237 TYR B O   1 
ATOM   4087 C  CB  . TYR B 1 237 ? 16.81907  -17.61467 -16.52495 1.000 56.24509 ? 237 TYR B CB  1 
ATOM   4088 C  CG  . TYR B 1 237 ? 17.22886  -18.56714 -17.62458 1.000 60.17174 ? 237 TYR B CG  1 
ATOM   4089 C  CD1 . TYR B 1 237 ? 18.01337  -18.13736 -18.68670 1.000 60.21772 ? 237 TYR B CD1 1 
ATOM   4090 C  CD2 . TYR B 1 237 ? 16.82326  -19.89432 -17.60537 1.000 62.80862 ? 237 TYR B CD2 1 
ATOM   4091 C  CE1 . TYR B 1 237 ? 18.38856  -19.00583 -19.69589 1.000 62.49667 ? 237 TYR B CE1 1 
ATOM   4092 C  CE2 . TYR B 1 237 ? 17.19243  -20.76957 -18.60851 1.000 61.59038 ? 237 TYR B CE2 1 
ATOM   4093 C  CZ  . TYR B 1 237 ? 17.97492  -20.32092 -19.65133 1.000 66.08945 ? 237 TYR B CZ  1 
ATOM   4094 O  OH  . TYR B 1 237 ? 18.34501  -21.19111 -20.65283 1.000 64.64999 ? 237 TYR B OH  1 
ATOM   4095 N  N   . ASN B 1 238 ? 17.80904  -16.38251 -13.24310 1.000 49.34597 ? 238 ASN B N   1 
ATOM   4096 C  CA  . ASN B 1 238 ? 17.38817  -15.44347 -12.20121 1.000 49.36524 ? 238 ASN B CA  1 
ATOM   4097 C  C   . ASN B 1 238 ? 15.86386  -15.34508 -12.12950 1.000 46.67731 ? 238 ASN B C   1 
ATOM   4098 O  O   . ASN B 1 238 ? 15.28389  -14.25779 -12.11545 1.000 39.52598 ? 238 ASN B O   1 
ATOM   4099 C  CB  . ASN B 1 238 ? 18.02292  -14.06466 -12.40533 1.000 43.14774 ? 238 ASN B CB  1 
ATOM   4100 C  CG  . ASN B 1 238 ? 19.49303  -14.04363 -12.04567 1.000 58.35087 ? 238 ASN B CG  1 
ATOM   4101 O  OD1 . ASN B 1 238 ? 19.93299  -14.76109 -11.14698 1.000 53.84349 ? 238 ASN B OD1 1 
ATOM   4102 N  ND2 . ASN B 1 238 ? 20.26320  -13.21876 -12.74670 1.000 61.04910 ? 238 ASN B ND2 1 
ATOM   4103 N  N   . TYR B 1 239 ? 15.21461  -16.50300 -12.09592 1.000 43.40981 ? 239 TYR B N   1 
ATOM   4104 C  CA  . TYR B 1 239 ? 13.78319  -16.59601 -11.85695 1.000 40.06331 ? 239 TYR B CA  1 
ATOM   4105 C  C   . TYR B 1 239 ? 13.54468  -17.08532 -10.43629 1.000 47.80647 ? 239 TYR B C   1 
ATOM   4106 O  O   . TYR B 1 239 ? 14.27958  -17.94030 -9.93373  1.000 48.26974 ? 239 TYR B O   1 
ATOM   4107 C  CB  . TYR B 1 239 ? 13.11447  -17.54446 -12.85459 1.000 42.90331 ? 239 TYR B CB  1 
ATOM   4108 C  CG  . TYR B 1 239 ? 12.51457  -16.85860 -14.05749 1.000 43.99789 ? 239 TYR B CG  1 
ATOM   4109 C  CD1 . TYR B 1 239 ? 13.30998  -16.14196 -14.93884 1.000 43.43137 ? 239 TYR B CD1 1 
ATOM   4110 C  CD2 . TYR B 1 239 ? 11.15164  -16.93606 -14.31684 1.000 46.64878 ? 239 TYR B CD2 1 
ATOM   4111 C  CE1 . TYR B 1 239 ? 12.76721  -15.51355 -16.03976 1.000 40.08497 ? 239 TYR B CE1 1 
ATOM   4112 C  CE2 . TYR B 1 239 ? 10.59859  -16.31348 -15.41691 1.000 36.25996 ? 239 TYR B CE2 1 
ATOM   4113 C  CZ  . TYR B 1 239 ? 11.41096  -15.60429 -16.27552 1.000 46.60913 ? 239 TYR B CZ  1 
ATOM   4114 O  OH  . TYR B 1 239 ? 10.86572  -14.98102 -17.37379 1.000 51.42335 ? 239 TYR B OH  1 
ATOM   4115 N  N   . GLU B 1 240 ? 12.52206  -16.53166 -9.79075  1.000 42.70438 ? 240 GLU B N   1 
ATOM   4116 C  CA  . GLU B 1 240 ? 12.17610  -16.96285 -8.44853  1.000 47.47714 ? 240 GLU B CA  1 
ATOM   4117 C  C   . GLU B 1 240 ? 11.76299  -18.43295 -8.46166  1.000 43.36481 ? 240 GLU B C   1 
ATOM   4118 O  O   . GLU B 1 240 ? 11.24134  -18.93106 -9.46308  1.000 44.52725 ? 240 GLU B O   1 
ATOM   4119 C  CB  . GLU B 1 240 ? 11.04323  -16.10719 -7.88397  1.000 41.87912 ? 240 GLU B CB  1 
ATOM   4120 C  CG  . GLU B 1 240 ? 11.47932  -14.72734 -7.43901  1.000 43.80743 ? 240 GLU B CG  1 
ATOM   4121 C  CD  . GLU B 1 240 ? 12.44570  -14.77901 -6.27190  1.000 47.07577 ? 240 GLU B CD  1 
ATOM   4122 O  OE1 . GLU B 1 240 ? 12.12294  -15.43752 -5.26058  1.000 47.64452 ? 240 GLU B OE1 1 
ATOM   4123 O  OE2 . GLU B 1 240 ? 13.53125  -14.16924 -6.36928  1.000 49.05116 ? 240 GLU B OE2 1 
ATOM   4124 N  N   . PRO B 1 241 ? 12.00485  -19.15631 -7.37113  1.000 48.90361 ? 241 PRO B N   1 
ATOM   4125 C  CA  . PRO B 1 241 ? 11.49438  -20.52624 -7.27844  1.000 47.50121 ? 241 PRO B CA  1 
ATOM   4126 C  C   . PRO B 1 241 ? 9.97472   -20.53594 -7.30551  1.000 46.43596 ? 241 PRO B C   1 
ATOM   4127 O  O   . PRO B 1 241 ? 9.31505   -19.62339 -6.80360  1.000 48.20470 ? 241 PRO B O   1 
ATOM   4128 C  CB  . PRO B 1 241 ? 12.03428  -21.02019 -5.93028  1.000 47.65823 ? 241 PRO B CB  1 
ATOM   4129 C  CG  . PRO B 1 241 ? 13.20030  -20.13604 -5.63626  1.000 46.18065 ? 241 PRO B CG  1 
ATOM   4130 C  CD  . PRO B 1 241 ? 12.85376  -18.80044 -6.22209  1.000 48.33777 ? 241 PRO B CD  1 
ATOM   4131 N  N   . LEU B 1 242 ? 9.41996   -21.57720 -7.91398  1.000 44.96171 ? 242 LEU B N   1 
ATOM   4132 C  CA  . LEU B 1 242 ? 7.97991   -21.78372 -7.94105  1.000 44.22780 ? 242 LEU B CA  1 
ATOM   4133 C  C   . LEU B 1 242 ? 7.61303   -22.73501 -6.81094  1.000 48.30150 ? 242 LEU B C   1 
ATOM   4134 O  O   . LEU B 1 242 ? 8.04700   -23.89205 -6.80328  1.000 48.47789 ? 242 LEU B O   1 
ATOM   4135 C  CB  . LEU B 1 242 ? 7.52332   -22.34073 -9.28886  1.000 44.93055 ? 242 LEU B CB  1 
ATOM   4136 C  CG  . LEU B 1 242 ? 6.01924   -22.21313 -9.54584  1.000 44.97519 ? 242 LEU B CG  1 
ATOM   4137 C  CD1 . LEU B 1 242 ? 5.63812   -20.75276 -9.71839  1.000 38.93939 ? 242 LEU B CD1 1 
ATOM   4138 C  CD2 . LEU B 1 242 ? 5.59353   -23.02153 -10.75587 1.000 46.00041 ? 242 LEU B CD2 1 
ATOM   4139 N  N   . THR B 1 243 ? 6.82858   -22.24565 -5.85849  1.000 50.52285 ? 243 THR B N   1 
ATOM   4140 C  CA  . THR B 1 243 ? 6.41920   -23.03175 -4.70595  1.000 51.55693 ? 243 THR B CA  1 
ATOM   4141 C  C   . THR B 1 243 ? 5.06573   -23.68457 -4.96293  1.000 54.23551 ? 243 THR B C   1 
ATOM   4142 O  O   . THR B 1 243 ? 4.35379   -23.35352 -5.91431  1.000 50.06576 ? 243 THR B O   1 
ATOM   4143 C  CB  . THR B 1 243 ? 6.35722   -22.15725 -3.45088  1.000 48.47658 ? 243 THR B CB  1 
ATOM   4144 O  OG1 . THR B 1 243 ? 5.25188   -21.25013 -3.55330  1.000 49.76240 ? 243 THR B OG1 1 
ATOM   4145 C  CG2 . THR B 1 243 ? 7.64590   -21.36156 -3.29741  1.000 49.14344 ? 243 THR B CG2 1 
ATOM   4146 N  N   . GLN B 1 244 ? 4.71546   -24.63348 -4.09115  1.000 49.99830 ? 244 GLN B N   1 
ATOM   4147 C  CA  . GLN B 1 244 ? 3.41936   -25.29095 -4.21082  1.000 46.91488 ? 244 GLN B CA  1 
ATOM   4148 C  C   . GLN B 1 244 ? 2.27779   -24.30996 -3.97940  1.000 54.98174 ? 244 GLN B C   1 
ATOM   4149 O  O   . GLN B 1 244 ? 1.19771   -24.46462 -4.56181  1.000 57.93245 ? 244 GLN B O   1 
ATOM   4150 C  CB  . GLN B 1 244 ? 3.33001   -26.46308 -3.23225  1.000 50.95026 ? 244 GLN B CB  1 
ATOM   4151 C  CG  . GLN B 1 244 ? 2.05526   -27.28129 -3.36437  1.000 52.95711 ? 244 GLN B CG  1 
ATOM   4152 C  CD  . GLN B 1 244 ? 1.83443   -27.78983 -4.77659  1.000 54.35910 ? 244 GLN B CD  1 
ATOM   4153 O  OE1 . GLN B 1 244 ? 2.76313   -28.26676 -5.43148  1.000 57.22089 ? 244 GLN B OE1 1 
ATOM   4154 N  NE2 . GLN B 1 244 ? 0.60073   -27.68393 -5.25606  1.000 55.10100 ? 244 GLN B NE2 1 
ATOM   4155 N  N   . ASP B 1 245 ? 2.49787   -23.29279 -3.14191  1.000 52.25682 ? 245 ASP B N   1 
ATOM   4156 C  CA  . ASP B 1 245 ? 1.48452   -22.25983 -2.95339  1.000 56.05667 ? 245 ASP B CA  1 
ATOM   4157 C  C   . ASP B 1 245 ? 1.24994   -21.48007 -4.24060  1.000 52.05356 ? 245 ASP B C   1 
ATOM   4158 O  O   . ASP B 1 245 ? 0.11477   -21.09298 -4.54295  1.000 54.22302 ? 245 ASP B O   1 
ATOM   4159 C  CB  . ASP B 1 245 ? 1.89729   -21.31689 -1.82340  1.000 61.08390 ? 245 ASP B CB  1 
ATOM   4160 C  CG  . ASP B 1 245 ? 1.85699   -21.98408 -0.46160  1.000 72.07403 ? 245 ASP B CG  1 
ATOM   4161 O  OD1 . ASP B 1 245 ? 1.38649   -23.13815 -0.37508  1.000 70.27836 ? 245 ASP B OD1 1 
ATOM   4162 O  OD2 . ASP B 1 245 ? 2.29585   -21.35327 0.52301   1.000 71.74981 ? 245 ASP B OD2 1 
ATOM   4163 N  N   . HIS B 1 246 ? 2.31367   -21.23991 -5.01209  1.000 52.72368 ? 246 HIS B N   1 
ATOM   4164 C  CA  . HIS B 1 246 ? 2.16173   -20.54800 -6.28763  1.000 50.91565 ? 246 HIS B CA  1 
ATOM   4165 C  C   . HIS B 1 246 ? 1.33362   -21.37275 -7.26404  1.000 49.83094 ? 246 HIS B C   1 
ATOM   4166 O  O   . HIS B 1 246 ? 0.48219   -20.83229 -7.98015  1.000 41.21688 ? 246 HIS B O   1 
ATOM   4167 C  CB  . HIS B 1 246 ? 3.53404   -20.23677 -6.88305  1.000 43.57473 ? 246 HIS B CB  1 
ATOM   4168 C  CG  . HIS B 1 246 ? 4.32300   -19.23221 -6.10280  1.000 50.07287 ? 246 HIS B CG  1 
ATOM   4169 N  ND1 . HIS B 1 246 ? 5.68922   -19.09995 -6.23064  1.000 48.46478 ? 246 HIS B ND1 1 
ATOM   4170 C  CD2 . HIS B 1 246 ? 3.93839   -18.30536 -5.19377  1.000 47.07038 ? 246 HIS B CD2 1 
ATOM   4171 C  CE1 . HIS B 1 246 ? 6.11303   -18.13807 -5.43045  1.000 46.99707 ? 246 HIS B CE1 1 
ATOM   4172 N  NE2 . HIS B 1 246 ? 5.07044   -17.63920 -4.79074  1.000 52.13389 ? 246 HIS B NE2 1 
ATOM   4173 N  N   . VAL B 1 247 ? 1.57310   -22.68524 -7.30932  1.000 49.29022 ? 247 VAL B N   1 
ATOM   4174 C  CA  . VAL B 1 247 ? 0.79071   -23.55684 -8.18179  1.000 49.58509 ? 247 VAL B CA  1 
ATOM   4175 C  C   . VAL B 1 247 ? -0.67710  -23.53935 -7.77568  1.000 44.07800 ? 247 VAL B C   1 
ATOM   4176 O  O   . VAL B 1 247 ? -1.57397  -23.56001 -8.62759  1.000 46.63139 ? 247 VAL B O   1 
ATOM   4177 C  CB  . VAL B 1 247 ? 1.36639   -24.98536 -8.16012  1.000 49.59899 ? 247 VAL B CB  1 
ATOM   4178 C  CG1 . VAL B 1 247 ? 0.55142   -25.90851 -9.05729  1.000 43.97780 ? 247 VAL B CG1 1 
ATOM   4179 C  CG2 . VAL B 1 247 ? 2.82812   -24.97303 -8.57662  1.000 46.59153 ? 247 VAL B CG2 1 
ATOM   4180 N  N   . ASP B 1 248 ? -0.94468  -23.48569 -6.46874  1.000 54.28996 ? 248 ASP B N   1 
ATOM   4181 C  CA  . ASP B 1 248 ? -2.32028  -23.55558 -5.98512  1.000 48.55462 ? 248 ASP B CA  1 
ATOM   4182 C  C   . ASP B 1 248 ? -3.13118  -22.33637 -6.41230  1.000 48.58711 ? 248 ASP B C   1 
ATOM   4183 O  O   . ASP B 1 248 ? -4.29404  -22.46975 -6.81113  1.000 45.77652 ? 248 ASP B O   1 
ATOM   4184 C  CB  . ASP B 1 248 ? -2.33038  -23.70581 -4.46261  1.000 55.49754 ? 248 ASP B CB  1 
ATOM   4185 C  CG  . ASP B 1 248 ? -1.77468  -25.04397 -4.00396  1.000 57.99798 ? 248 ASP B CG  1 
ATOM   4186 O  OD1 . ASP B 1 248 ? -1.56926  -25.92927 -4.86089  1.000 56.06535 ? 248 ASP B OD1 1 
ATOM   4187 O  OD2 . ASP B 1 248 ? -1.53984  -25.21107 -2.78795  1.000 59.30524 ? 248 ASP B OD2 1 
ATOM   4188 N  N   . ILE B 1 249 ? -2.54274  -21.14001 -6.33769  1.000 50.02840 ? 249 ILE B N   1 
ATOM   4189 C  CA  . ILE B 1 249 ? -3.29484  -19.93918 -6.68982  1.000 42.96823 ? 249 ILE B CA  1 
ATOM   4190 C  C   . ILE B 1 249 ? -3.45586  -19.78971 -8.19805  1.000 48.96159 ? 249 ILE B C   1 
ATOM   4191 O  O   . ILE B 1 249 ? -4.38562  -19.10913 -8.65029  1.000 45.75996 ? 249 ILE B O   1 
ATOM   4192 C  CB  . ILE B 1 249 ? -2.64353  -18.67999 -6.09259  1.000 46.74414 ? 249 ILE B CB  1 
ATOM   4193 C  CG1 . ILE B 1 249 ? -1.27345  -18.42414 -6.71677  1.000 43.03190 ? 249 ILE B CG1 1 
ATOM   4194 C  CG2 . ILE B 1 249 ? -2.52345  -18.80729 -4.57721  1.000 45.45267 ? 249 ILE B CG2 1 
ATOM   4195 C  CD1 . ILE B 1 249 ? -0.59570  -17.17711 -6.19512  1.000 55.28933 ? 249 ILE B CD1 1 
ATOM   4196 N  N   . LEU B 1 250 ? -2.58200  -20.41101 -8.99308  1.000 45.50795 ? 250 LEU B N   1 
ATOM   4197 C  CA  . LEU B 1 250 ? -2.80021  -20.49063 -10.43329 1.000 42.23310 ? 250 LEU B CA  1 
ATOM   4198 C  C   . LEU B 1 250 ? -3.88953  -21.48717 -10.80124 1.000 46.30821 ? 250 LEU B C   1 
ATOM   4199 O  O   . LEU B 1 250 ? -4.21530  -21.61089 -11.98742 1.000 46.17006 ? 250 LEU B O   1 
ATOM   4200 C  CB  . LEU B 1 250 ? -1.49848  -20.86479 -11.14546 1.000 41.14288 ? 250 LEU B CB  1 
ATOM   4201 C  CG  . LEU B 1 250 ? -0.37702  -19.82355 -11.16833 1.000 38.68656 ? 250 LEU B CG  1 
ATOM   4202 C  CD1 . LEU B 1 250 ? 0.92202   -20.45182 -11.64498 1.000 30.56833 ? 250 LEU B CD1 1 
ATOM   4203 C  CD2 . LEU B 1 250 ? -0.75653  -18.64342 -12.05050 1.000 36.00856 ? 250 LEU B CD2 1 
ATOM   4204 N  N   . GLY B 1 251 ? -4.44723  -22.19049 -9.81560  1.000 46.46861 ? 251 GLY B N   1 
ATOM   4205 C  CA  . GLY B 1 251 ? -5.47983  -23.17899 -10.02569 1.000 44.17884 ? 251 GLY B CA  1 
ATOM   4206 C  C   . GLY B 1 251 ? -6.68335  -22.70043 -10.81710 1.000 43.37755 ? 251 GLY B C   1 
ATOM   4207 O  O   . GLY B 1 251 ? -7.10105  -23.34783 -11.78255 1.000 50.21417 ? 251 GLY B O   1 
ATOM   4208 N  N   . PRO B 1 252 ? -7.29067  -21.57783 -10.40813 1.000 46.39924 ? 252 PRO B N   1 
ATOM   4209 C  CA  . PRO B 1 252 ? -8.43696  -21.06026 -11.17779 1.000 39.96758 ? 252 PRO B CA  1 
ATOM   4210 C  C   . PRO B 1 252 ? -8.12587  -20.81790 -12.64468 1.000 46.71126 ? 252 PRO B C   1 
ATOM   4211 O  O   . PRO B 1 252 ? -8.96044  -21.11947 -13.50689 1.000 50.76134 ? 252 PRO B O   1 
ATOM   4212 C  CB  . PRO B 1 252 ? -8.78176  -19.75727 -10.44623 1.000 39.65681 ? 252 PRO B CB  1 
ATOM   4213 C  CG  . PRO B 1 252 ? -8.34679  -19.99799 -9.05159  1.000 43.07135 ? 252 PRO B CG  1 
ATOM   4214 C  CD  . PRO B 1 252 ? -7.10598  -20.83957 -9.14513  1.000 44.77612 ? 252 PRO B CD  1 
ATOM   4215 N  N   . LEU B 1 253 ? -6.94379  -20.28081 -12.95647 1.000 51.62361 ? 253 LEU B N   1 
ATOM   4216 C  CA  . LEU B 1 253 ? -6.57144  -20.08770 -14.35420 1.000 45.39917 ? 253 LEU B CA  1 
ATOM   4217 C  C   . LEU B 1 253 ? -6.29944  -21.41491 -15.05034 1.000 44.27789 ? 253 LEU B C   1 
ATOM   4218 O  O   . LEU B 1 253 ? -6.55723  -21.54735 -16.25223 1.000 41.51246 ? 253 LEU B O   1 
ATOM   4219 C  CB  . LEU B 1 253 ? -5.35074  -19.17418 -14.44800 1.000 43.39737 ? 253 LEU B CB  1 
ATOM   4220 C  CG  . LEU B 1 253 ? -5.55879  -17.73723 -13.96598 1.000 43.32006 ? 253 LEU B CG  1 
ATOM   4221 C  CD1 . LEU B 1 253 ? -4.22900  -17.00973 -13.84248 1.000 36.23242 ? 253 LEU B CD1 1 
ATOM   4222 C  CD2 . LEU B 1 253 ? -6.49354  -16.99374 -14.90829 1.000 41.51061 ? 253 LEU B CD2 1 
ATOM   4223 N  N   . SER B 1 254 ? -5.78046  -22.40234 -14.31620 1.000 48.91364 ? 254 SER B N   1 
ATOM   4224 C  CA  . SER B 1 254 ? -5.56104  -23.72382 -14.89540 1.000 49.61852 ? 254 SER B CA  1 
ATOM   4225 C  C   . SER B 1 254 ? -6.87916  -24.38267 -15.28016 1.000 50.16098 ? 254 SER B C   1 
ATOM   4226 O  O   . SER B 1 254 ? -6.99194  -24.98523 -16.35380 1.000 53.08672 ? 254 SER B O   1 
ATOM   4227 C  CB  . SER B 1 254 ? -4.79170  -24.60521 -13.91132 1.000 48.07894 ? 254 SER B CB  1 
ATOM   4228 O  OG  . SER B 1 254 ? -4.88503  -25.97365 -14.26757 1.000 56.92957 ? 254 SER B OG  1 
ATOM   4229 N  N   . ALA B 1 255 ? -7.88926  -24.27864 -14.41527 1.000 49.87825 ? 255 ALA B N   1 
ATOM   4230 C  CA  . ALA B 1 255 ? -9.18064  -24.88887 -14.71223 1.000 53.29684 ? 255 ALA B CA  1 
ATOM   4231 C  C   . ALA B 1 255 ? -9.89356  -24.15974 -15.84291 1.000 49.69026 ? 255 ALA B C   1 
ATOM   4232 O  O   . ALA B 1 255 ? -10.52205 -24.79383 -16.69778 1.000 57.76630 ? 255 ALA B O   1 
ATOM   4233 C  CB  . ALA B 1 255 ? -10.04988 -24.91253 -13.45537 1.000 48.72260 ? 255 ALA B CB  1 
ATOM   4234 N  N   . GLN B 1 256 ? -9.80022  -22.82951 -15.87015 1.000 51.53662 ? 256 GLN B N   1 
ATOM   4235 C  CA  . GLN B 1 256 ? -10.53543 -22.04782 -16.85787 1.000 50.68496 ? 256 GLN B CA  1 
ATOM   4236 C  C   . GLN B 1 256 ? -9.96730  -22.19244 -18.26455 1.000 49.23560 ? 256 GLN B C   1 
ATOM   4237 O  O   . GLN B 1 256 ? -10.69827 -21.98492 -19.23899 1.000 53.11610 ? 256 GLN B O   1 
ATOM   4238 C  CB  . GLN B 1 256 ? -10.55032 -20.57354 -16.44776 1.000 45.60433 ? 256 GLN B CB  1 
ATOM   4239 C  CG  . GLN B 1 256 ? -11.51071 -19.70541 -17.24480 1.000 47.02440 ? 256 GLN B CG  1 
ATOM   4240 C  CD  . GLN B 1 256 ? -10.83545 -18.48853 -17.84484 1.000 60.70495 ? 256 GLN B CD  1 
ATOM   4241 O  OE1 . GLN B 1 256 ? -10.57551 -17.50216 -17.15392 1.000 58.97751 ? 256 GLN B OE1 1 
ATOM   4242 N  NE2 . GLN B 1 256 ? -10.54824 -18.55190 -19.14118 1.000 68.24885 ? 256 GLN B NE2 1 
ATOM   4243 N  N   . THR B 1 257 ? -8.68929  -22.54764 -18.39710 1.000 47.74050 ? 257 THR B N   1 
ATOM   4244 C  CA  . THR B 1 257 ? -8.06629  -22.68313 -19.70544 1.000 46.49315 ? 257 THR B CA  1 
ATOM   4245 C  C   . THR B 1 257 ? -7.81279  -24.12388 -20.11870 1.000 46.10006 ? 257 THR B C   1 
ATOM   4246 O  O   . THR B 1 257 ? -7.62391  -24.38050 -21.31181 1.000 45.65573 ? 257 THR B O   1 
ATOM   4247 C  CB  . THR B 1 257 ? -6.72931  -21.92578 -19.75044 1.000 43.77222 ? 257 THR B CB  1 
ATOM   4248 O  OG1 . THR B 1 257 ? -5.81657  -22.50506 -18.81032 1.000 47.56762 ? 257 THR B OG1 1 
ATOM   4249 C  CG2 . THR B 1 257 ? -6.93342  -20.45317 -19.42414 1.000 47.81806 ? 257 THR B CG2 1 
ATOM   4250 N  N   . GLY B 1 258 ? -7.80775  -25.06250 -19.17745 1.000 41.40880 ? 258 GLY B N   1 
ATOM   4251 C  CA  . GLY B 1 258 ? -7.42830  -26.42183 -19.48976 1.000 46.98120 ? 258 GLY B CA  1 
ATOM   4252 C  C   . GLY B 1 258 ? -5.93860  -26.64703 -19.58753 1.000 48.47542 ? 258 GLY B C   1 
ATOM   4253 O  O   . GLY B 1 258 ? -5.51680  -27.70300 -20.07213 1.000 51.40586 ? 258 GLY B O   1 
ATOM   4254 N  N   . ILE B 1 259 ? -5.12984  -25.68910 -19.14591 1.000 44.33378 ? 259 ILE B N   1 
ATOM   4255 C  CA  . ILE B 1 259 ? -3.67674  -25.78487 -19.18620 1.000 46.81631 ? 259 ILE B CA  1 
ATOM   4256 C  C   . ILE B 1 259 ? -3.19429  -25.96737 -17.75406 1.000 48.03346 ? 259 ILE B C   1 
ATOM   4257 O  O   . ILE B 1 259 ? -3.24983  -25.03010 -16.94861 1.000 50.11388 ? 259 ILE B O   1 
ATOM   4258 C  CB  . ILE B 1 259 ? -3.04358  -24.54470 -19.83061 1.000 43.73106 ? 259 ILE B CB  1 
ATOM   4259 C  CG1 . ILE B 1 259 ? -3.78073  -24.17593 -21.11977 1.000 48.60023 ? 259 ILE B CG1 1 
ATOM   4260 C  CG2 . ILE B 1 259 ? -1.56719  -24.78292 -20.10528 1.000 45.09572 ? 259 ILE B CG2 1 
ATOM   4261 C  CD1 . ILE B 1 259 ? -3.67157  -25.21695 -22.20818 1.000 50.79765 ? 259 ILE B CD1 1 
ATOM   4262 N  N   . ALA B 1 260 ? -2.72969  -27.17146 -17.42842 1.000 48.62057 ? 260 ALA B N   1 
ATOM   4263 C  CA  . ALA B 1 260 ? -2.19627  -27.42317 -16.09745 1.000 48.09150 ? 260 ALA B CA  1 
ATOM   4264 C  C   . ALA B 1 260 ? -0.96379  -26.55974 -15.85055 1.000 46.73243 ? 260 ALA B C   1 
ATOM   4265 O  O   . ALA B 1 260 ? -0.24812  -26.17816 -16.78075 1.000 45.39479 ? 260 ALA B O   1 
ATOM   4266 C  CB  . ALA B 1 260 ? -1.85042  -28.90268 -15.92870 1.000 48.82780 ? 260 ALA B CB  1 
ATOM   4267 N  N   . VAL B 1 261 ? -0.72127  -26.25294 -14.57364 1.000 48.77268 ? 261 VAL B N   1 
ATOM   4268 C  CA  . VAL B 1 261 ? 0.33314   -25.30586 -14.21614 1.000 40.49469 ? 261 VAL B CA  1 
ATOM   4269 C  C   . VAL B 1 261 ? 1.68911   -25.79650 -14.70503 1.000 44.41111 ? 261 VAL B C   1 
ATOM   4270 O  O   . VAL B 1 261 ? 2.48542   -25.02430 -15.25332 1.000 46.69671 ? 261 VAL B O   1 
ATOM   4271 C  CB  . VAL B 1 261 ? 0.33593   -25.05957 -12.69625 1.000 45.42277 ? 261 VAL B CB  1 
ATOM   4272 C  CG1 . VAL B 1 261 ? 1.50790   -24.17063 -12.30318 1.000 44.72498 ? 261 VAL B CG1 1 
ATOM   4273 C  CG2 . VAL B 1 261 ? -0.98426  -24.44220 -12.25738 1.000 43.00779 ? 261 VAL B CG2 1 
ATOM   4274 N  N   . LEU B 1 262 ? 1.97191   -27.08592 -14.52579 1.000 44.98102 ? 262 LEU B N   1 
ATOM   4275 C  CA  . LEU B 1 262 ? 3.25676   -27.62639 -14.94824 1.000 47.84662 ? 262 LEU B CA  1 
ATOM   4276 C  C   . LEU B 1 262 ? 3.35994   -27.77151 -16.46234 1.000 49.16041 ? 262 LEU B C   1 
ATOM   4277 O  O   . LEU B 1 262 ? 4.47429   -27.90353 -16.98232 1.000 47.29211 ? 262 LEU B O   1 
ATOM   4278 C  CB  . LEU B 1 262 ? 3.51754   -28.96805 -14.25571 1.000 48.56175 ? 262 LEU B CB  1 
ATOM   4279 C  CG  . LEU B 1 262 ? 3.80917   -28.88964 -12.74832 1.000 44.35512 ? 262 LEU B CG  1 
ATOM   4280 C  CD1 . LEU B 1 262 ? 2.52916   -28.81806 -11.92463 1.000 48.73567 ? 262 LEU B CD1 1 
ATOM   4281 C  CD2 . LEU B 1 262 ? 4.67663   -30.05065 -12.28535 1.000 54.93180 ? 262 LEU B CD2 1 
ATOM   4282 N  N   . ASP B 1 263 ? 2.23093   -27.75052 -17.17842 1.000 52.69917 ? 263 ASP B N   1 
ATOM   4283 C  CA  . ASP B 1 263 ? 2.28054   -27.57310 -18.62677 1.000 48.53573 ? 263 ASP B CA  1 
ATOM   4284 C  C   . ASP B 1 263 ? 2.74364   -26.16531 -18.97394 1.000 45.57692 ? 263 ASP B C   1 
ATOM   4285 O  O   . ASP B 1 263 ? 3.63745   -25.97876 -19.80802 1.000 45.99903 ? 263 ASP B O   1 
ATOM   4286 C  CB  . ASP B 1 263 ? 0.90919   -27.84712 -19.24850 1.000 48.18456 ? 263 ASP B CB  1 
ATOM   4287 C  CG  . ASP B 1 263 ? 0.48561   -29.29682 -19.12656 1.000 63.43481 ? 263 ASP B CG  1 
ATOM   4288 O  OD1 . ASP B 1 263 ? 1.35650   -30.18676 -19.22489 1.000 66.34497 ? 263 ASP B OD1 1 
ATOM   4289 O  OD2 . ASP B 1 263 ? -0.72460  -29.54568 -18.93709 1.000 65.56915 ? 263 ASP B OD2 1 
ATOM   4290 N  N   . MET B 1 264 ? 2.14434   -25.15880 -18.33214 1.000 49.10807 ? 264 MET B N   1 
ATOM   4291 C  CA  . MET B 1 264 ? 2.54769   -23.77886 -18.57041 1.000 45.07314 ? 264 MET B CA  1 
ATOM   4292 C  C   . MET B 1 264 ? 4.00287   -23.55129 -18.18005 1.000 44.59083 ? 264 MET B C   1 
ATOM   4293 O  O   . MET B 1 264 ? 4.68622   -22.71904 -18.78806 1.000 43.72181 ? 264 MET B O   1 
ATOM   4294 C  CB  . MET B 1 264 ? 1.62106   -22.83105 -17.80577 1.000 33.88899 ? 264 MET B CB  1 
ATOM   4295 C  CG  . MET B 1 264 ? 1.64665   -21.40457 -18.31427 1.000 42.71397 ? 264 MET B CG  1 
ATOM   4296 S  SD  . MET B 1 264 ? 1.10764   -21.28569 -20.03343 1.000 41.84593 ? 264 MET B SD  1 
ATOM   4297 C  CE  . MET B 1 264 ? -0.64948  -21.03069 -19.83109 1.000 36.29707 ? 264 MET B CE  1 
ATOM   4298 N  N   . CYS B 1 265 ? 4.49616   -24.28388 -17.17692 1.000 46.21319 ? 265 CYS B N   1 
ATOM   4299 C  CA  . CYS B 1 265 ? 5.91442   -24.21250 -16.83791 1.000 44.83208 ? 265 CYS B CA  1 
ATOM   4300 C  C   . CYS B 1 265 ? 6.77594   -24.78478 -17.95484 1.000 46.46860 ? 265 CYS B C   1 
ATOM   4301 O  O   . CYS B 1 265 ? 7.85376   -24.25377 -18.24985 1.000 47.65799 ? 265 CYS B O   1 
ATOM   4302 C  CB  . CYS B 1 265 ? 6.18160   -24.94922 -15.52723 1.000 47.23551 ? 265 CYS B CB  1 
ATOM   4303 S  SG  . CYS B 1 265 ? 5.42481   -24.18222 -14.08637 1.000 47.08183 ? 265 CYS B SG  1 
ATOM   4304 N  N   . ALA B 1 266 ? 6.32334   -25.87449 -18.57987 1.000 49.99979 ? 266 ALA B N   1 
ATOM   4305 C  CA  . ALA B 1 266 ? 7.02835   -26.39568 -19.74508 1.000 47.82046 ? 266 ALA B CA  1 
ATOM   4306 C  C   . ALA B 1 266 ? 7.06079   -25.36332 -20.86311 1.000 47.32983 ? 266 ALA B C   1 
ATOM   4307 O  O   . ALA B 1 266 ? 8.08229   -25.20144 -21.53941 1.000 46.90461 ? 266 ALA B O   1 
ATOM   4308 C  CB  . ALA B 1 266 ? 6.37446   -27.69165 -20.22299 1.000 52.88509 ? 266 ALA B CB  1 
ATOM   4309 N  N   . SER B 1 267 ? 5.95279   -24.64394 -21.06274 1.000 49.38727 ? 267 SER B N   1 
ATOM   4310 C  CA  . SER B 1 267 ? 5.94863   -23.54796 -22.02552 1.000 45.05601 ? 267 SER B CA  1 
ATOM   4311 C  C   . SER B 1 267 ? 6.90797   -22.44369 -21.60187 1.000 40.42289 ? 267 SER B C   1 
ATOM   4312 O  O   . SER B 1 267 ? 7.62885   -21.88293 -22.43558 1.000 44.84185 ? 267 SER B O   1 
ATOM   4313 C  CB  . SER B 1 267 ? 4.53215   -22.99328 -22.18704 1.000 42.70958 ? 267 SER B CB  1 
ATOM   4314 O  OG  . SER B 1 267 ? 3.65512   -23.96662 -22.72613 1.000 48.46829 ? 267 SER B OG  1 
ATOM   4315 N  N   . LEU B 1 268 ? 6.93420   -22.12004 -20.30637 1.000 43.83527 ? 268 LEU B N   1 
ATOM   4316 C  CA  . LEU B 1 268 ? 7.81125   -21.05547 -19.83098 1.000 40.30651 ? 268 LEU B CA  1 
ATOM   4317 C  C   . LEU B 1 268 ? 9.27622   -21.46184 -19.92285 1.000 44.11898 ? 268 LEU B C   1 
ATOM   4318 O  O   . LEU B 1 268 ? 10.12693  -20.64907 -20.30397 1.000 49.96737 ? 268 LEU B O   1 
ATOM   4319 C  CB  . LEU B 1 268 ? 7.44923   -20.67421 -18.39569 1.000 47.08996 ? 268 LEU B CB  1 
ATOM   4320 C  CG  . LEU B 1 268 ? 8.32224   -19.58519 -17.76737 1.000 41.61063 ? 268 LEU B CG  1 
ATOM   4321 C  CD1 . LEU B 1 268 ? 8.33537   -18.34797 -18.64907 1.000 40.83604 ? 268 LEU B CD1 1 
ATOM   4322 C  CD2 . LEU B 1 268 ? 7.84598   -19.23862 -16.36364 1.000 39.88515 ? 268 LEU B CD2 1 
ATOM   4323 N  N   . LYS B 1 269 ? 9.58993   -22.71322 -19.57846 1.000 49.35150 ? 269 LYS B N   1 
ATOM   4324 C  CA  . LYS B 1 269 ? 10.97025  -23.18251 -19.66160 1.000 51.17888 ? 269 LYS B CA  1 
ATOM   4325 C  C   . LYS B 1 269 ? 11.49401  -23.09120 -21.08984 1.000 52.03681 ? 269 LYS B C   1 
ATOM   4326 O  O   . LYS B 1 269 ? 12.61992  -22.63569 -21.32322 1.000 54.59996 ? 269 LYS B O   1 
ATOM   4327 C  CB  . LYS B 1 269 ? 11.06822  -24.61639 -19.13959 1.000 52.27871 ? 269 LYS B CB  1 
ATOM   4328 N  N   . GLU B 1 270 ? 10.68216  -23.51485 -22.06308 1.000 56.28410 ? 270 GLU B N   1 
ATOM   4329 C  CA  . GLU B 1 270 ? 11.09584  -23.42838 -23.46056 1.000 59.34094 ? 270 GLU B CA  1 
ATOM   4330 C  C   . GLU B 1 270 ? 11.29358  -21.97998 -23.88586 1.000 60.51071 ? 270 GLU B C   1 
ATOM   4331 O  O   . GLU B 1 270 ? 12.23035  -21.66516 -24.62927 1.000 60.71919 ? 270 GLU B O   1 
ATOM   4332 C  CB  . GLU B 1 270 ? 10.06853  -24.11577 -24.36087 1.000 60.95065 ? 270 GLU B CB  1 
ATOM   4333 C  CG  . GLU B 1 270 ? 9.86405   -25.59209 -24.05945 1.000 63.24644 ? 270 GLU B CG  1 
ATOM   4334 C  CD  . GLU B 1 270 ? 11.14691  -26.39409 -24.15982 1.000 73.90509 ? 270 GLU B CD  1 
ATOM   4335 O  OE1 . GLU B 1 270 ? 11.95968  -26.11093 -25.06568 1.000 78.23843 ? 270 GLU B OE1 1 
ATOM   4336 O  OE2 . GLU B 1 270 ? 11.34473  -27.30608 -23.32952 1.000 74.71686 ? 270 GLU B OE2 1 
ATOM   4337 N  N   . LEU B 1 271 ? 10.42080  -21.08230 -23.42261 1.000 52.76473 ? 271 LEU B N   1 
ATOM   4338 C  CA  . LEU B 1 271 ? 10.60293  -19.66466 -23.71063 1.000 47.14856 ? 271 LEU B CA  1 
ATOM   4339 C  C   . LEU B 1 271 ? 11.86676  -19.12050 -23.05764 1.000 56.49729 ? 271 LEU B C   1 
ATOM   4340 O  O   . LEU B 1 271 ? 12.51741  -18.22858 -23.61372 1.000 55.56568 ? 271 LEU B O   1 
ATOM   4341 C  CB  . LEU B 1 271 ? 9.37809   -18.87634 -23.24753 1.000 48.04011 ? 271 LEU B CB  1 
ATOM   4342 C  CG  . LEU B 1 271 ? 8.12946   -18.96928 -24.12627 1.000 46.78717 ? 271 LEU B CG  1 
ATOM   4343 C  CD1 . LEU B 1 271 ? 6.89552   -18.54594 -23.34883 1.000 46.41678 ? 271 LEU B CD1 1 
ATOM   4344 C  CD2 . LEU B 1 271 ? 8.30040   -18.10717 -25.36533 1.000 51.38487 ? 271 LEU B CD2 1 
ATOM   4345 N  N   . LEU B 1 272 ? 12.23280  -19.64486 -21.88501 1.000 53.11721 ? 272 LEU B N   1 
ATOM   4346 C  CA  . LEU B 1 272 ? 13.44202  -19.18081 -21.21142 1.000 53.95122 ? 272 LEU B CA  1 
ATOM   4347 C  C   . LEU B 1 272 ? 14.69419  -19.55557 -21.99342 1.000 58.72936 ? 272 LEU B C   1 
ATOM   4348 O  O   . LEU B 1 272 ? 15.60605  -18.73492 -22.14829 1.000 59.13552 ? 272 LEU B O   1 
ATOM   4349 C  CB  . LEU B 1 272 ? 13.50738  -19.75373 -19.79649 1.000 57.53965 ? 272 LEU B CB  1 
ATOM   4350 C  CG  . LEU B 1 272 ? 12.53315  -19.14122 -18.79261 1.000 52.01171 ? 272 LEU B CG  1 
ATOM   4351 C  CD1 . LEU B 1 272 ? 12.73899  -19.72857 -17.40715 1.000 48.84388 ? 272 LEU B CD1 1 
ATOM   4352 C  CD2 . LEU B 1 272 ? 12.70019  -17.63502 -18.77444 1.000 41.75744 ? 272 LEU B CD2 1 
ATOM   4353 N  N   . GLN B 1 273 ? 14.75713  -20.78927 -22.49241 1.000 64.15434 ? 273 GLN B N   1 
ATOM   4354 C  CA  . GLN B 1 273 ? 15.93361  -21.24588 -23.22340 1.000 61.76197 ? 273 GLN B CA  1 
ATOM   4355 C  C   . GLN B 1 273 ? 15.92595  -20.73413 -24.65983 1.000 64.96087 ? 273 GLN B C   1 
ATOM   4356 O  O   . GLN B 1 273 ? 16.87532  -20.07945 -25.10406 1.000 68.53158 ? 273 GLN B O   1 
ATOM   4357 C  CB  . GLN B 1 273 ? 15.99977  -22.77527 -23.19303 1.000 56.77981 ? 273 GLN B CB  1 
ATOM   4358 C  CG  . GLN B 1 273 ? 16.10568  -23.35825 -21.79216 1.000 58.35984 ? 273 GLN B CG  1 
ATOM   4359 C  CD  . GLN B 1 273 ? 15.42255  -24.70538 -21.66812 1.000 64.97126 ? 273 GLN B CD  1 
ATOM   4360 O  OE1 . GLN B 1 273 ? 14.75796  -25.16414 -22.59714 1.000 75.33714 ? 273 GLN B OE1 1 
ATOM   4361 N  NE2 . GLN B 1 273 ? 15.57715  -25.34463 -20.51440 1.000 61.15068 ? 273 GLN B NE2 1 
ATOM   4362 N  N   . ASN B 1 274 ? 14.85260  -21.01578 -25.39540 1.000 61.91658 ? 274 ASN B N   1 
ATOM   4363 C  CA  . ASN B 1 274 ? 14.77417  -20.70064 -26.81605 1.000 63.98254 ? 274 ASN B CA  1 
ATOM   4364 C  C   . ASN B 1 274 ? 14.44182  -19.23864 -27.09181 1.000 66.97048 ? 274 ASN B C   1 
ATOM   4365 O  O   . ASN B 1 274 ? 14.44278  -18.83344 -28.25976 1.000 66.53324 ? 274 ASN B O   1 
ATOM   4366 C  CB  . ASN B 1 274 ? 13.73964  -21.60862 -27.48649 1.000 65.98690 ? 274 ASN B CB  1 
ATOM   4367 C  CG  . ASN B 1 274 ? 13.82988  -23.04542 -27.00361 1.000 71.51587 ? 274 ASN B CG  1 
ATOM   4368 O  OD1 . ASN B 1 274 ? 14.91701  -23.55032 -26.72194 1.000 73.75802 ? 274 ASN B OD1 1 
ATOM   4369 N  ND2 . ASN B 1 274 ? 12.68267  -23.70762 -26.89416 1.000 72.52106 ? 274 ASN B ND2 1 
ATOM   4370 N  N   . GLY B 1 275 ? 14.15291  -18.44600 -26.05978 1.000 66.90968 ? 275 GLY B N   1 
ATOM   4371 C  CA  . GLY B 1 275 ? 13.93263  -17.02129 -26.22431 1.000 62.23656 ? 275 GLY B CA  1 
ATOM   4372 C  C   . GLY B 1 275 ? 12.66243  -16.67207 -26.99007 1.000 65.96679 ? 275 GLY B C   1 
ATOM   4373 O  O   . GLY B 1 275 ? 11.79352  -17.50461 -27.25851 1.000 60.95294 ? 275 GLY B O   1 
ATOM   4374 N  N   . MET B 1 276 ? 12.56982  -15.38965 -27.32793 1.000 67.16206 ? 276 MET B N   1 
ATOM   4375 C  CA  . MET B 1 276 ? 11.50079  -14.82636 -28.14851 1.000 73.28467 ? 276 MET B CA  1 
ATOM   4376 C  C   . MET B 1 276 ? 12.03105  -14.07984 -29.36205 1.000 69.34741 ? 276 MET B C   1 
ATOM   4377 O  O   . MET B 1 276 ? 11.48784  -14.24242 -30.45913 1.000 72.71201 ? 276 MET B O   1 
ATOM   4378 C  CB  . MET B 1 276 ? 10.61411  -13.89077 -27.30667 1.000 70.45858 ? 276 MET B CB  1 
ATOM   4379 C  CG  . MET B 1 276 ? 9.32541   -14.53227 -26.81878 1.000 68.84300 ? 276 MET B CG  1 
ATOM   4380 S  SD  . MET B 1 276 ? 8.33722   -13.43004 -25.78908 1.000 63.12982 ? 276 MET B SD  1 
ATOM   4381 C  CE  . MET B 1 276 ? 9.43822   -13.22649 -24.39621 1.000 49.96320 ? 276 MET B CE  1 
ATOM   4382 N  N   . ASN B 1 277 ? 13.06803  -13.25701 -29.18682 1.000 70.51873 ? 277 ASN B N   1 
ATOM   4383 C  CA  . ASN B 1 277 ? 13.81689  -12.66142 -30.29525 1.000 67.18718 ? 277 ASN B CA  1 
ATOM   4384 C  C   . ASN B 1 277 ? 12.92607  -11.80631 -31.19630 1.000 69.95313 ? 277 ASN B C   1 
ATOM   4385 O  O   . ASN B 1 277 ? 13.09795  -11.77152 -32.41634 1.000 70.23292 ? 277 ASN B O   1 
ATOM   4386 C  CB  . ASN B 1 277 ? 14.53519  -13.74408 -31.10320 1.000 60.51081 ? 277 ASN B CB  1 
ATOM   4387 C  CG  . ASN B 1 277 ? 15.20462  -14.77855 -30.21747 1.000 70.13299 ? 277 ASN B CG  1 
ATOM   4388 O  OD1 . ASN B 1 277 ? 14.98682  -15.97985 -30.37112 1.000 70.98756 ? 277 ASN B OD1 1 
ATOM   4389 N  ND2 . ASN B 1 277 ? 16.01456  -14.31361 -29.27417 1.000 64.81600 ? 277 ASN B ND2 1 
ATOM   4390 N  N   . GLY B 1 278 ? 11.96873  -11.10317 -30.59262 1.000 67.76644 ? 278 GLY B N   1 
ATOM   4391 C  CA  . GLY B 1 278 ? 11.08742  -10.20440 -31.30718 1.000 65.66795 ? 278 GLY B CA  1 
ATOM   4392 C  C   . GLY B 1 278 ? 9.65395   -10.67806 -31.41643 1.000 61.60368 ? 278 GLY B C   1 
ATOM   4393 O  O   . GLY B 1 278 ? 8.75769   -9.84653  -31.61128 1.000 66.41107 ? 278 GLY B O   1 
ATOM   4394 N  N   . ARG B 1 279 ? 9.41076   -11.98348 -31.31820 1.000 68.04393 ? 279 ARG B N   1 
ATOM   4395 C  CA  . ARG B 1 279 ? 8.04585   -12.49355 -31.32408 1.000 68.79403 ? 279 ARG B CA  1 
ATOM   4396 C  C   . ARG B 1 279 ? 7.34893   -12.11830 -30.02212 1.000 56.67029 ? 279 ARG B C   1 
ATOM   4397 O  O   . ARG B 1 279 ? 7.94678   -12.16987 -28.94397 1.000 61.31067 ? 279 ARG B O   1 
ATOM   4398 C  CB  . ARG B 1 279 ? 8.04579   -14.00911 -31.50902 1.000 61.09492 ? 279 ARG B CB  1 
ATOM   4399 C  CG  . ARG B 1 279 ? 8.93579   -14.49883 -32.64327 1.000 72.33232 ? 279 ARG B CG  1 
ATOM   4400 C  CD  . ARG B 1 279 ? 8.99923   -16.01590 -32.64313 1.000 76.83136 ? 279 ARG B CD  1 
ATOM   4401 N  NE  . ARG B 1 279 ? 9.50259   -16.52797 -31.37400 1.000 73.64565 ? 279 ARG B NE  1 
ATOM   4402 C  CZ  . ARG B 1 279 ? 10.59161  -17.27247 -31.24468 1.000 68.66319 ? 279 ARG B CZ  1 
ATOM   4403 N  NH1 . ARG B 1 279 ? 11.29638  -17.65321 -32.29669 1.000 67.93318 ? 279 ARG B NH1 1 
ATOM   4404 N  NH2 . ARG B 1 279 ? 10.97686  -17.65313 -30.02993 1.000 67.10297 ? 279 ARG B NH2 1 
ATOM   4405 N  N   . THR B 1 280 ? 6.07769   -11.74272 -30.12072 1.000 52.75187 ? 280 THR B N   1 
ATOM   4406 C  CA  . THR B 1 280 ? 5.38755   -11.09845 -29.01434 1.000 45.51915 ? 280 THR B CA  1 
ATOM   4407 C  C   . THR B 1 280 ? 4.30356   -11.98813 -28.41941 1.000 45.96921 ? 280 THR B C   1 
ATOM   4408 O  O   . THR B 1 280 ? 3.81256   -12.93116 -29.04674 1.000 42.16756 ? 280 THR B O   1 
ATOM   4409 C  CB  . THR B 1 280 ? 4.76543   -9.76931  -29.45456 1.000 42.42488 ? 280 THR B CB  1 
ATOM   4410 O  OG1 . THR B 1 280 ? 3.69120   -10.02245 -30.36725 1.000 41.70256 ? 280 THR B OG1 1 
ATOM   4411 C  CG2 . THR B 1 280 ? 5.81234   -8.89151  -30.13226 1.000 44.75392 ? 280 THR B CG2 1 
ATOM   4412 N  N   . ILE B 1 281 ? 3.94444   -11.65730 -27.17936 1.000 42.50070 ? 281 ILE B N   1 
ATOM   4413 C  CA  . ILE B 1 281 ? 2.83999   -12.26609 -26.44676 1.000 37.36544 ? 281 ILE B CA  1 
ATOM   4414 C  C   . ILE B 1 281 ? 2.08791   -11.13349 -25.76386 1.000 35.70323 ? 281 ILE B C   1 
ATOM   4415 O  O   . ILE B 1 281 ? 2.67628   -10.39371 -24.96691 1.000 40.38725 ? 281 ILE B O   1 
ATOM   4416 C  CB  . ILE B 1 281 ? 3.32173   -13.28881 -25.40320 1.000 42.52073 ? 281 ILE B CB  1 
ATOM   4417 C  CG1 . ILE B 1 281 ? 3.99186   -14.48323 -26.08189 1.000 39.96290 ? 281 ILE B CG1 1 
ATOM   4418 C  CG2 . ILE B 1 281 ? 2.16722   -13.73632 -24.52730 1.000 36.61842 ? 281 ILE B CG2 1 
ATOM   4419 C  CD1 . ILE B 1 281 ? 4.63654   -15.44379 -25.11097 1.000 40.33411 ? 281 ILE B CD1 1 
ATOM   4420 N  N   . LEU B 1 282 ? 0.80011   -10.98869 -26.07357 1.000 37.54910 ? 282 LEU B N   1 
ATOM   4421 C  CA  . LEU B 1 282 ? 0.00989   -9.84562  -25.61549 1.000 34.14147 ? 282 LEU B CA  1 
ATOM   4422 C  C   . LEU B 1 282 ? 0.70202   -8.53070  -25.97344 1.000 29.91614 ? 282 LEU B C   1 
ATOM   4423 O  O   . LEU B 1 282 ? 0.79299   -7.60364  -25.16668 1.000 35.79076 ? 282 LEU B O   1 
ATOM   4424 C  CB  . LEU B 1 282 ? -0.26775  -9.93122  -24.11083 1.000 41.87607 ? 282 LEU B CB  1 
ATOM   4425 C  CG  . LEU B 1 282 ? -1.29826  -10.96336 -23.65276 1.000 37.69385 ? 282 LEU B CG  1 
ATOM   4426 C  CD1 . LEU B 1 282 ? -1.33480  -11.04618 -22.13284 1.000 32.09001 ? 282 LEU B CD1 1 
ATOM   4427 C  CD2 . LEU B 1 282 ? -2.67711  -10.62871 -24.20962 1.000 32.24317 ? 282 LEU B CD2 1 
ATOM   4428 N  N   . GLY B 1 283 ? 1.21086   -8.46634  -27.20267 1.000 40.82563 ? 283 GLY B N   1 
ATOM   4429 C  CA  . GLY B 1 283 ? 1.87908   -7.27315  -27.68807 1.000 40.54735 ? 283 GLY B CA  1 
ATOM   4430 C  C   . GLY B 1 283 ? 3.16782   -6.92490  -26.97938 1.000 46.60821 ? 283 GLY B C   1 
ATOM   4431 O  O   . GLY B 1 283 ? 3.63018   -5.78452  -27.08090 1.000 48.73505 ? 283 GLY B O   1 
ATOM   4432 N  N   . SER B 1 284 ? 3.76607   -7.87221  -26.26075 1.000 41.62568 ? 284 SER B N   1 
ATOM   4433 C  CA  . SER B 1 284 ? 4.99637   -7.63854  -25.51764 1.000 42.18236 ? 284 SER B CA  1 
ATOM   4434 C  C   . SER B 1 284 ? 6.07391   -8.59833  -25.99956 1.000 37.45896 ? 284 SER B C   1 
ATOM   4435 O  O   . SER B 1 284 ? 5.81823   -9.79694  -26.16102 1.000 39.50204 ? 284 SER B O   1 
ATOM   4436 C  CB  . SER B 1 284 ? 4.77410   -7.81007  -24.01412 1.000 34.61924 ? 284 SER B CB  1 
ATOM   4437 O  OG  . SER B 1 284 ? 6.00000   -7.70436  -23.31516 1.000 39.40227 ? 284 SER B OG  1 
ATOM   4438 N  N   . ALA B 1 285 ? 7.27593   -8.07115  -26.21683 1.000 39.31793 ? 285 ALA B N   1 
ATOM   4439 C  CA  . ALA B 1 285 ? 8.40794   -8.86812  -26.66825 1.000 45.14527 ? 285 ALA B CA  1 
ATOM   4440 C  C   . ALA B 1 285 ? 9.20502   -9.47392  -25.51998 1.000 44.17383 ? 285 ALA B C   1 
ATOM   4441 O  O   . ALA B 1 285 ? 10.21644  -10.13797 -25.76998 1.000 53.06074 ? 285 ALA B O   1 
ATOM   4442 C  CB  . ALA B 1 285 ? 9.33301   -8.02118  -27.54747 1.000 44.98369 ? 285 ALA B CB  1 
ATOM   4443 N  N   . LEU B 1 286 ? 8.78614   -9.25662  -24.27568 1.000 43.44477 ? 286 LEU B N   1 
ATOM   4444 C  CA  . LEU B 1 286 ? 9.41170   -9.87241  -23.11487 1.000 42.87589 ? 286 LEU B CA  1 
ATOM   4445 C  C   . LEU B 1 286 ? 8.32891   -10.40639 -22.18372 1.000 40.18489 ? 286 LEU B C   1 
ATOM   4446 O  O   . LEU B 1 286 ? 7.14037   -10.11469 -22.33911 1.000 35.03067 ? 286 LEU B O   1 
ATOM   4447 C  CB  . LEU B 1 286 ? 10.34114  -8.89021  -22.38236 1.000 40.87938 ? 286 LEU B CB  1 
ATOM   4448 C  CG  . LEU B 1 286 ? 9.84876   -7.49824  -21.97283 1.000 49.33129 ? 286 LEU B CG  1 
ATOM   4449 C  CD1 . LEU B 1 286 ? 9.07731   -7.52460  -20.65628 1.000 51.50108 ? 286 LEU B CD1 1 
ATOM   4450 C  CD2 . LEU B 1 286 ? 11.03067  -6.54224  -21.88808 1.000 44.32674 ? 286 LEU B CD2 1 
ATOM   4451 N  N   . LEU B 1 287 ? 8.75515   -11.20381 -21.20759 1.000 38.58349 ? 287 LEU B N   1 
ATOM   4452 C  CA  . LEU B 1 287 ? 7.83659   -11.86552 -20.28659 1.000 40.32724 ? 287 LEU B CA  1 
ATOM   4453 C  C   . LEU B 1 287 ? 7.47863   -10.90980 -19.15344 1.000 37.62133 ? 287 LEU B C   1 
ATOM   4454 O  O   . LEU B 1 287 ? 8.33250   -10.55814 -18.33264 1.000 42.91302 ? 287 LEU B O   1 
ATOM   4455 C  CB  . LEU B 1 287 ? 8.46575   -13.15128 -19.75912 1.000 36.07735 ? 287 LEU B CB  1 
ATOM   4456 C  CG  . LEU B 1 287 ? 8.82206   -14.16519 -20.85061 1.000 43.34964 ? 287 LEU B CG  1 
ATOM   4457 C  CD1 . LEU B 1 287 ? 9.59636   -15.34034 -20.28174 1.000 52.44921 ? 287 LEU B CD1 1 
ATOM   4458 C  CD2 . LEU B 1 287 ? 7.57032   -14.64878 -21.56950 1.000 39.68545 ? 287 LEU B CD2 1 
ATOM   4459 N  N   . GLU B 1 288 ? 6.21416   -10.49277 -19.10915 1.000 40.13563 ? 288 GLU B N   1 
ATOM   4460 C  CA  . GLU B 1 288 ? 5.73602   -9.57555  -18.08188 1.000 35.90884 ? 288 GLU B CA  1 
ATOM   4461 C  C   . GLU B 1 288 ? 5.53797   -10.30410 -16.75798 1.000 31.36156 ? 288 GLU B C   1 
ATOM   4462 O  O   . GLU B 1 288 ? 4.98537   -11.40667 -16.72023 1.000 32.23363 ? 288 GLU B O   1 
ATOM   4463 C  CB  . GLU B 1 288 ? 4.41882   -8.93163  -18.52088 1.000 33.06149 ? 288 GLU B CB  1 
ATOM   4464 C  CG  . GLU B 1 288 ? 4.50567   -8.16563  -19.83185 1.000 48.95780 ? 288 GLU B CG  1 
ATOM   4465 C  CD  . GLU B 1 288 ? 5.18942   -6.82099  -19.67574 1.000 57.40718 ? 288 GLU B CD  1 
ATOM   4466 O  OE1 . GLU B 1 288 ? 5.12256   -6.24140  -18.57052 1.000 50.93114 ? 288 GLU B OE1 1 
ATOM   4467 O  OE2 . GLU B 1 288 ? 5.79636   -6.34429  -20.65706 1.000 59.49842 ? 288 GLU B OE2 1 
ATOM   4468 N  N   . ASP B 1 289 ? 5.98039   -9.67471  -15.65998 1.000 36.10303 ? 289 ASP B N   1 
ATOM   4469 C  CA  . ASP B 1 289 ? 5.87044   -10.28775 -14.33924 1.000 36.33400 ? 289 ASP B CA  1 
ATOM   4470 C  C   . ASP B 1 289 ? 5.28541   -9.33723  -13.29852 1.000 38.18288 ? 289 ASP B C   1 
ATOM   4471 O  O   . ASP B 1 289 ? 5.52767   -9.51605  -12.09829 1.000 33.41236 ? 289 ASP B O   1 
ATOM   4472 C  CB  . ASP B 1 289 ? 7.22894   -10.81601 -13.86400 1.000 32.18939 ? 289 ASP B CB  1 
ATOM   4473 C  CG  . ASP B 1 289 ? 8.19264   -9.70844  -13.45245 1.000 38.42718 ? 289 ASP B CG  1 
ATOM   4474 O  OD1 . ASP B 1 289 ? 8.03658   -8.55589  -13.90594 1.000 38.38374 ? 289 ASP B OD1 1 
ATOM   4475 O  OD2 . ASP B 1 289 ? 9.12204   -10.00744 -12.67054 1.000 34.98785 ? 289 ASP B OD2 1 
ATOM   4476 N  N   . GLU B 1 290 ? 4.51496   -8.33501  -13.71839 1.000 32.70401 ? 290 GLU B N   1 
ATOM   4477 C  CA  . GLU B 1 290 ? 3.87350   -7.42393  -12.77873 1.000 39.51736 ? 290 GLU B CA  1 
ATOM   4478 C  C   . GLU B 1 290 ? 2.35275   -7.55721  -12.81188 1.000 30.07485 ? 290 GLU B C   1 
ATOM   4479 O  O   . GLU B 1 290 ? 1.62842   -6.58332  -12.59271 1.000 36.30697 ? 290 GLU B O   1 
ATOM   4480 C  CB  . GLU B 1 290 ? 4.31294   -5.98461  -13.04389 1.000 36.34040 ? 290 GLU B CB  1 
ATOM   4481 C  CG  . GLU B 1 290 ? 5.83107   -5.82128  -13.02799 1.000 38.92043 ? 290 GLU B CG  1 
ATOM   4482 C  CD  . GLU B 1 290 ? 6.29952   -4.49136  -12.45298 1.000 36.62353 ? 290 GLU B CD  1 
ATOM   4483 O  OE1 . GLU B 1 290 ? 5.53205   -3.50863  -12.48165 1.000 40.38187 ? 290 GLU B OE1 1 
ATOM   4484 O  OE2 . GLU B 1 290 ? 7.45014   -4.43263  -11.96722 1.000 50.26885 ? 290 GLU B OE2 1 
ATOM   4485 N  N   . PHE B 1 291 ? 1.86365   -8.76338  -13.09942 1.000 28.66591 ? 291 PHE B N   1 
ATOM   4486 C  CA  . PHE B 1 291 ? 0.45409   -9.11829  -12.96528 1.000 32.08037 ? 291 PHE B CA  1 
ATOM   4487 C  C   . PHE B 1 291 ? 0.36616   -10.37297 -12.11128 1.000 37.39873 ? 291 PHE B C   1 
ATOM   4488 O  O   . PHE B 1 291 ? 0.88924   -11.42241 -12.49977 1.000 32.23710 ? 291 PHE B O   1 
ATOM   4489 C  CB  . PHE B 1 291 ? -0.20588  -9.37774  -14.32379 1.000 30.25306 ? 291 PHE B CB  1 
ATOM   4490 C  CG  . PHE B 1 291 ? -0.18057  -8.20537  -15.26029 1.000 31.83587 ? 291 PHE B CG  1 
ATOM   4491 C  CD1 . PHE B 1 291 ? 0.85059   -8.05266  -16.17255 1.000 35.17677 ? 291 PHE B CD1 1 
ATOM   4492 C  CD2 . PHE B 1 291 ? -1.20623  -7.27368  -15.25295 1.000 33.42637 ? 291 PHE B CD2 1 
ATOM   4493 C  CE1 . PHE B 1 291 ? 0.86958   -6.98153  -17.04884 1.000 31.84986 ? 291 PHE B CE1 1 
ATOM   4494 C  CE2 . PHE B 1 291 ? -1.19404  -6.20109  -16.12725 1.000 39.51707 ? 291 PHE B CE2 1 
ATOM   4495 C  CZ  . PHE B 1 291 ? -0.15284  -6.05530  -17.02542 1.000 35.34369 ? 291 PHE B CZ  1 
ATOM   4496 N  N   . THR B 1 292 ? -0.29074  -10.27287 -10.96122 1.000 32.99563 ? 292 THR B N   1 
ATOM   4497 C  CA  . THR B 1 292 ? -0.50119  -11.43341 -10.10887 1.000 29.91285 ? 292 THR B CA  1 
ATOM   4498 C  C   . THR B 1 292 ? -1.60717  -12.30487 -10.69276 1.000 32.41097 ? 292 THR B C   1 
ATOM   4499 O  O   . THR B 1 292 ? -2.33605  -11.88282 -11.59402 1.000 31.40989 ? 292 THR B O   1 
ATOM   4500 C  CB  . THR B 1 292 ? -0.85040  -10.98254 -8.69115  1.000 33.42441 ? 292 THR B CB  1 
ATOM   4501 O  OG1 . THR B 1 292 ? -2.16265  -10.40550 -8.68295  1.000 29.57909 ? 292 THR B OG1 1 
ATOM   4502 C  CG2 . THR B 1 292 ? 0.15779   -9.95771  -8.19092  1.000 27.72855 ? 292 THR B CG2 1 
ATOM   4503 N  N   . PRO B 1 293 ? -1.74679  -13.54857 -10.21526 1.000 36.19803 ? 293 PRO B N   1 
ATOM   4504 C  CA  . PRO B 1 293 ? -2.92003  -14.34490 -10.61709 1.000 32.87372 ? 293 PRO B CA  1 
ATOM   4505 C  C   . PRO B 1 293 ? -4.23737  -13.64515 -10.32975 1.000 34.13277 ? 293 PRO B C   1 
ATOM   4506 O  O   . PRO B 1 293 ? -5.17492  -13.73046 -11.13231 1.000 32.77941 ? 293 PRO B O   1 
ATOM   4507 C  CB  . PRO B 1 293 ? -2.76428  -15.63020 -9.79473  1.000 32.98095 ? 293 PRO B CB  1 
ATOM   4508 C  CG  . PRO B 1 293 ? -1.30133  -15.75067 -9.57051  1.000 39.43396 ? 293 PRO B CG  1 
ATOM   4509 C  CD  . PRO B 1 293 ? -0.77931  -14.34594 -9.43723  1.000 33.97334 ? 293 PRO B CD  1 
ATOM   4510 N  N   . PHE B 1 294 ? -4.32397  -12.93754 -9.20282  1.000 38.11567 ? 294 PHE B N   1 
ATOM   4511 C  CA  . PHE B 1 294 ? -5.54849  -12.22122 -8.86718  1.000 39.74910 ? 294 PHE B CA  1 
ATOM   4512 C  C   . PHE B 1 294 ? -5.78149  -11.05112 -9.81373  1.000 36.74989 ? 294 PHE B C   1 
ATOM   4513 O  O   . PHE B 1 294 ? -6.92842  -10.75266 -10.16584 1.000 37.40422 ? 294 PHE B O   1 
ATOM   4514 C  CB  . PHE B 1 294 ? -5.48550  -11.75212 -7.41566  1.000 44.96995 ? 294 PHE B CB  1 
ATOM   4515 C  CG  . PHE B 1 294 ? -5.09087  -12.83897 -6.44938  1.000 57.88296 ? 294 PHE B CG  1 
ATOM   4516 C  CD1 . PHE B 1 294 ? -6.04145  -13.70827 -5.93852  1.000 58.31163 ? 294 PHE B CD1 1 
ATOM   4517 C  CD2 . PHE B 1 294 ? -3.76784  -12.99563 -6.05984  1.000 60.76132 ? 294 PHE B CD2 1 
ATOM   4518 C  CE1 . PHE B 1 294 ? -5.68176  -14.71021 -5.05568  1.000 55.78030 ? 294 PHE B CE1 1 
ATOM   4519 C  CE2 . PHE B 1 294 ? -3.40391  -13.99548 -5.17770  1.000 64.71650 ? 294 PHE B CE2 1 
ATOM   4520 C  CZ  . PHE B 1 294 ? -4.36313  -14.85310 -4.67460  1.000 58.33859 ? 294 PHE B CZ  1 
ATOM   4521 N  N   . ASP B 1 295 ? -4.70628  -10.37808 -10.23510 1.000 37.20497 ? 295 ASP B N   1 
ATOM   4522 C  CA  . ASP B 1 295 ? -4.83442  -9.34140  -11.25485 1.000 31.08804 ? 295 ASP B CA  1 
ATOM   4523 C  C   . ASP B 1 295 ? -5.42550  -9.90720  -12.53886 1.000 37.51424 ? 295 ASP B C   1 
ATOM   4524 O  O   . ASP B 1 295 ? -6.30153  -9.28895  -13.15542 1.000 35.00902 ? 295 ASP B O   1 
ATOM   4525 C  CB  . ASP B 1 295 ? -3.47308  -8.70294  -11.54361 1.000 35.24435 ? 295 ASP B CB  1 
ATOM   4526 C  CG  . ASP B 1 295 ? -2.89635  -7.97368  -10.34360 1.000 39.07446 ? 295 ASP B CG  1 
ATOM   4527 O  OD1 . ASP B 1 295 ? -3.66092  -7.67391  -9.40337  1.000 39.56301 ? 295 ASP B OD1 1 
ATOM   4528 O  OD2 . ASP B 1 295 ? -1.67946  -7.69301  -10.34550 1.000 31.77539 ? 295 ASP B OD2 1 
ATOM   4529 N  N   . VAL B 1 296 ? -4.95444  -11.08387 -12.95607 1.000 35.39340 ? 296 VAL B N   1 
ATOM   4530 C  CA  . VAL B 1 296 ? -5.42544  -11.68502 -14.20099 1.000 32.09271 ? 296 VAL B CA  1 
ATOM   4531 C  C   . VAL B 1 296 ? -6.90477  -12.03552 -14.09689 1.000 35.92302 ? 296 VAL B C   1 
ATOM   4532 O  O   . VAL B 1 296 ? -7.69327  -11.75698 -15.00833 1.000 34.39260 ? 296 VAL B O   1 
ATOM   4533 C  CB  . VAL B 1 296 ? -4.57617  -12.91990 -14.55143 1.000 32.27482 ? 296 VAL B CB  1 
ATOM   4534 C  CG1 . VAL B 1 296 ? -5.14826  -13.62307 -15.76628 1.000 32.77390 ? 296 VAL B CG1 1 
ATOM   4535 C  CG2 . VAL B 1 296 ? -3.12116  -12.51939 -14.78443 1.000 30.94009 ? 296 VAL B CG2 1 
ATOM   4536 N  N   . VAL B 1 297 ? -7.30315  -12.64967 -12.98038 1.000 38.10872 ? 297 VAL B N   1 
ATOM   4537 C  CA  . VAL B 1 297 ? -8.69293  -13.06491 -12.81170 1.000 36.12923 ? 297 VAL B CA  1 
ATOM   4538 C  C   . VAL B 1 297 ? -9.61565  -11.85256 -12.75924 1.000 41.09397 ? 297 VAL B C   1 
ATOM   4539 O  O   . VAL B 1 297 ? -10.69941 -11.85490 -13.35597 1.000 44.75099 ? 297 VAL B O   1 
ATOM   4540 C  CB  . VAL B 1 297 ? -8.83561  -13.94465 -11.55598 1.000 38.22339 ? 297 VAL B CB  1 
ATOM   4541 C  CG1 . VAL B 1 297 ? -10.29000 -14.29833 -11.31642 1.000 44.54025 ? 297 VAL B CG1 1 
ATOM   4542 C  CG2 . VAL B 1 297 ? -8.00414  -15.20951 -11.69861 1.000 35.39981 ? 297 VAL B CG2 1 
ATOM   4543 N  N   . ARG B 1 298 ? -9.20136  -10.79529 -12.05693 1.000 37.08850 ? 298 ARG B N   1 
ATOM   4544 C  CA  . ARG B 1 298 ? -10.04315 -9.60721  -11.95159 1.000 40.39261 ? 298 ARG B CA  1 
ATOM   4545 C  C   . ARG B 1 298 ? -10.22160 -8.92808  -13.30507 1.000 45.18370 ? 298 ARG B C   1 
ATOM   4546 O  O   . ARG B 1 298 ? -11.29668 -8.39470  -13.60213 1.000 43.89440 ? 298 ARG B O   1 
ATOM   4547 C  CB  . ARG B 1 298 ? -9.44993  -8.63141  -10.93559 1.000 39.24274 ? 298 ARG B CB  1 
ATOM   4548 N  N   . GLN B 1 299 ? -9.18669  -8.94500  -14.14431 1.000 34.55373 ? 299 GLN B N   1 
ATOM   4549 C  CA  . GLN B 1 299 ? -9.25147  -8.24051  -15.41852 1.000 40.42459 ? 299 GLN B CA  1 
ATOM   4550 C  C   . GLN B 1 299 ? -9.82271  -9.09172  -16.54555 1.000 44.75852 ? 299 GLN B C   1 
ATOM   4551 O  O   . GLN B 1 299 ? -10.50707 -8.55724  -17.42704 1.000 42.55530 ? 299 GLN B O   1 
ATOM   4552 C  CB  . GLN B 1 299 ? -7.86016  -7.73213  -15.81640 1.000 32.44545 ? 299 GLN B CB  1 
ATOM   4553 C  CG  . GLN B 1 299 ? -7.85977  -6.89178  -17.08705 1.000 32.22433 ? 299 GLN B CG  1 
ATOM   4554 C  CD  . GLN B 1 299 ? -6.50942  -6.27665  -17.40181 1.000 35.39499 ? 299 GLN B CD  1 
ATOM   4555 O  OE1 . GLN B 1 299 ? -6.32458  -5.67569  -18.45965 1.000 34.23915 ? 299 GLN B OE1 1 
ATOM   4556 N  NE2 . GLN B 1 299 ? -5.55889  -6.42045  -16.48354 1.000 31.09961 ? 299 GLN B NE2 1 
ATOM   4557 N  N   . CYS B 1 300 ? -9.57205  -10.40095 -16.54013 1.000 43.62959 ? 300 CYS B N   1 
ATOM   4558 C  CA  . CYS B 1 300 ? -9.99120  -11.24382 -17.65406 1.000 43.65079 ? 300 CYS B CA  1 
ATOM   4559 C  C   . CYS B 1 300 ? -11.38506 -11.83241 -17.48070 1.000 45.71944 ? 300 CYS B C   1 
ATOM   4560 O  O   . CYS B 1 300 ? -12.07989 -12.05196 -18.48032 1.000 52.18060 ? 300 CYS B O   1 
ATOM   4561 C  CB  . CYS B 1 300 ? -8.98530  -12.37724 -17.86707 1.000 29.40605 ? 300 CYS B CB  1 
ATOM   4562 S  SG  . CYS B 1 300 ? -7.42855  -11.83565 -18.59062 1.000 44.24841 ? 300 CYS B SG  1 
ATOM   4563 N  N   . SER B 1 301 ? -11.81013 -12.10915 -16.24651 1.000 44.39525 ? 301 SER B N   1 
ATOM   4564 C  CA  . SER B 1 301 ? -13.12924 -12.67592 -16.00954 1.000 50.36734 ? 301 SER B CA  1 
ATOM   4565 C  C   . SER B 1 301 ? -13.97773 -11.85812 -15.04569 1.000 48.33750 ? 301 SER B C   1 
ATOM   4566 O  O   . SER B 1 301 ? -15.14331 -12.20791 -14.83007 1.000 56.00078 ? 301 SER B O   1 
ATOM   4567 C  CB  . SER B 1 301 ? -13.01294 -14.11681 -15.48634 1.000 57.18848 ? 301 SER B CB  1 
ATOM   4568 O  OG  . SER B 1 301 ? -12.29050 -14.16662 -14.26877 1.000 60.14123 ? 301 SER B OG  1 
ATOM   4569 N  N   . GLY B 1 302 ? -13.43985 -10.78839 -14.46888 1.000 50.27595 ? 302 GLY B N   1 
ATOM   4570 C  CA  . GLY B 1 302 ? -14.22847 -9.94262  -13.58436 1.000 56.50017 ? 302 GLY B CA  1 
ATOM   4571 C  C   . GLY B 1 302 ? -14.69759 -10.63378 -12.32166 1.000 65.71486 ? 302 GLY B C   1 
ATOM   4572 O  O   . GLY B 1 302 ? -15.79819 -10.34849 -11.83355 1.000 71.81493 ? 302 GLY B O   1 
ATOM   4573 N  N   . VAL B 1 303 ? -13.88810 -11.54111 -11.78266 1.000 62.10006 ? 303 VAL B N   1 
ATOM   4574 C  CA  . VAL B 1 303 ? -14.24734 -12.25913 -10.56460 1.000 65.88797 ? 303 VAL B CA  1 
ATOM   4575 C  C   . VAL B 1 303 ? -13.63266 -11.57421 -9.34886  1.000 62.91291 ? 303 VAL B C   1 
ATOM   4576 O  O   . VAL B 1 303 ? -12.41422 -11.42326 -9.26080  1.000 60.99010 ? 303 VAL B O   1 
ATOM   4577 C  CB  . VAL B 1 303 ? -13.81465 -13.73214 -10.63516 1.000 55.85645 ? 303 VAL B CB  1 
HETATM 4578 C  C1  . XEK C 2 .   ? -20.09595 -4.75031  -26.89945 1.000 41.90786 ? 401 XEK A C1  1 
HETATM 4579 C  C2  . XEK C 2 .   ? -21.41233 -4.48898  -27.25252 1.000 46.14315 ? 401 XEK A C2  1 
HETATM 4580 C  C3  . XEK C 2 .   ? -21.81389 -4.32706  -28.72053 1.000 46.63741 ? 401 XEK A C3  1 
HETATM 4581 C  C4  . XEK C 2 .   ? -22.33540 -3.11396  -29.14785 1.000 47.33024 ? 401 XEK A C4  1 
HETATM 4582 C  C5  . XEK C 2 .   ? -22.70661 -2.94666  -30.47404 1.000 52.48189 ? 401 XEK A C5  1 
HETATM 4583 C  C6  . XEK C 2 .   ? -22.55942 -3.99376  -31.37681 1.000 57.00063 ? 401 XEK A C6  1 
HETATM 4584 C  C7  . XEK C 2 .   ? -22.04069 -5.21348  -30.95211 1.000 59.52839 ? 401 XEK A C7  1 
HETATM 4585 C  C8  . XEK C 2 .   ? -20.53451 -6.54708  -32.16152 1.000 68.71789 ? 401 XEK A C8  1 
HETATM 4586 C  C9  . XEK C 2 .   ? -20.43290 -7.46279  -33.38684 1.000 69.50283 ? 401 XEK A C9  1 
HETATM 4587 C  C10 . XEK C 2 .   ? -20.83880 -8.78966  -33.29881 1.000 71.12581 ? 401 XEK A C10 1 
HETATM 4588 C  C11 . XEK C 2 .   ? -20.74447 -9.62180  -34.40963 1.000 76.82707 ? 401 XEK A C11 1 
HETATM 4589 C  C12 . XEK C 2 .   ? -20.23979 -9.13243  -35.60931 1.000 74.97231 ? 401 XEK A C12 1 
HETATM 4590 C  C13 . XEK C 2 .   ? -19.82971 -7.80815  -35.69837 1.000 73.03548 ? 401 XEK A C13 1 
HETATM 4591 C  C14 . XEK C 2 .   ? -19.92477 -6.97656  -34.58865 1.000 71.68110 ? 401 XEK A C14 1 
HETATM 4592 C  C15 . XEK C 2 .   ? -21.66759 -5.37768  -29.62143 1.000 51.24050 ? 401 XEK A C15 1 
HETATM 4593 C  C17 . XEK C 2 .   ? -22.02541 -4.50982  -24.93438 1.000 49.77670 ? 401 XEK A C17 1 
HETATM 4594 C  C21 . XEK C 2 .   ? -26.73479 -5.07543  -23.62582 1.000 63.99354 ? 401 XEK A C21 1 
HETATM 4595 C  C22 . XEK C 2 .   ? -25.14005 -4.14520  -22.06884 1.000 59.09340 ? 401 XEK A C22 1 
HETATM 4596 C  C24 . XEK C 2 .   ? -18.39746 -5.15949  -25.25219 1.000 42.58358 ? 401 XEK A C24 1 
HETATM 4597 C  C25 . XEK C 2 .   ? -18.01315 -6.43377  -24.85331 1.000 46.21812 ? 401 XEK A C25 1 
HETATM 4598 C  C27 . XEK C 2 .   ? -15.78498 -5.59023  -24.61320 1.000 35.81362 ? 401 XEK A C27 1 
HETATM 4599 C  C16 . XEK C 2 .   ? -22.38240 -4.36712  -26.26889 1.000 54.68156 ? 401 XEK A C16 1 
HETATM 4600 C  C18 . XEK C 2 .   ? -23.12080 -4.36928  -23.87099 1.000 54.90911 ? 401 XEK A C18 1 
HETATM 4601 C  C19 . XEK C 2 .   ? -22.89307 -3.84297  -22.60113 1.000 48.80530 ? 401 XEK A C19 1 
HETATM 4602 C  C20 . XEK C 2 .   ? -24.41406 -4.76616  -24.18505 1.000 57.64545 ? 401 XEK A C20 1 
HETATM 4603 C  C23 . XEK C 2 .   ? -20.69319 -4.77909  -24.63575 1.000 45.32530 ? 401 XEK A C23 1 
HETATM 4604 C  C26 . XEK C 2 .   ? -16.67721 -6.65135  -24.52716 1.000 42.71710 ? 401 XEK A C26 1 
HETATM 4605 C  C28 . XEK C 2 .   ? -17.45747 -4.13675  -25.31953 1.000 40.46464 ? 401 XEK A C28 1 
HETATM 4606 F  F1  . XEK C 2 .   ? -22.92535 -3.81948  -32.67727 1.000 51.21962 ? 401 XEK A F1  1 
HETATM 4607 N  N1  . XEK C 2 .   ? -23.90688 -3.74857  -21.73494 1.000 51.49138 ? 401 XEK A N1  1 
HETATM 4608 N  N2  . XEK C 2 .   ? -25.38932 -4.64870  -23.28214 1.000 63.57028 ? 401 XEK A N2  1 
HETATM 4609 N  N3  . XEK C 2 .   ? -19.77804 -4.88631  -25.60605 1.000 50.72750 ? 401 XEK A N3  1 
HETATM 4610 N  N4  . XEK C 2 .   ? -16.18231 -4.37379  -25.00135 1.000 36.36430 ? 401 XEK A N4  1 
HETATM 4611 O  O1  . XEK C 2 .   ? -19.11753 -4.87551  -27.89390 1.000 41.73084 ? 401 XEK A O1  1 
HETATM 4612 O  O2  . XEK C 2 .   ? -21.88377 -6.27284  -31.86591 1.000 67.52179 ? 401 XEK A O2  1 
HETATM 4613 O  O3  . XEK C 2 .   ? -21.61925 -3.41234  -22.21334 1.000 47.63273 ? 401 XEK A O3  1 
HETATM 4614 O  O4  . XEK C 2 .   ? -26.02077 -4.05075  -21.28107 1.000 62.36924 ? 401 XEK A O4  1 
HETATM 4615 CL CL1 . XEK C 2 .   ? -23.36815 -1.37808  -31.00855 1.000 60.48723 ? 401 XEK A CL1 1 
HETATM 4616 CL CL2 . XEK C 2 .   ? -19.39325 -5.28052  -34.72256 1.000 69.89483 ? 401 XEK A CL2 1 
HETATM 4617 O  O   . HOH D 3 .   ? -12.10103 20.69003  -12.65655 1.000 46.48331 ? 501 HOH A O   1 
HETATM 4618 O  O   . HOH D 3 .   ? -8.68865  13.15416  -11.17656 1.000 36.94031 ? 502 HOH A O   1 
HETATM 4619 O  O   . HOH D 3 .   ? 17.815    4.973     -46.609   1.000 30.17247 ? 503 HOH A O   1 
HETATM 4620 O  O   . HOH D 3 .   ? -29.26758 8.25068   -37.03847 1.000 45.03738 ? 504 HOH A O   1 
HETATM 4621 O  O   . HOH D 3 .   ? 8.55033   -1.61559  -34.50611 1.000 42.85757 ? 505 HOH A O   1 
HETATM 4622 O  O   . HOH D 3 .   ? -10.65842 -6.28983  -19.07041 1.000 35.98176 ? 506 HOH A O   1 
HETATM 4623 O  O   . HOH D 3 .   ? 15.35212  -4.99949  -42.93305 1.000 35.27690 ? 507 HOH A O   1 
HETATM 4624 O  O   . HOH D 3 .   ? -22.42754 -2.35908  -16.91258 1.000 38.05319 ? 508 HOH A O   1 
HETATM 4625 O  O   . HOH D 3 .   ? -4.66831  1.79959   -28.18258 1.000 25.61502 ? 509 HOH A O   1 
HETATM 4626 O  O   . HOH D 3 .   ? -17.69269 15.46627  -33.29042 1.000 38.92312 ? 510 HOH A O   1 
HETATM 4627 O  O   . HOH D 3 .   ? -22.78863 16.06519  -26.75695 1.000 36.49464 ? 511 HOH A O   1 
HETATM 4628 O  O   . HOH D 3 .   ? -13.52727 3.80555   -33.13896 1.000 28.71624 ? 512 HOH A O   1 
HETATM 4629 O  O   . HOH D 3 .   ? 15.46480  11.76537  -50.62466 1.000 33.04005 ? 513 HOH A O   1 
HETATM 4630 O  O   . HOH D 3 .   ? 18.85618  9.82610   -47.36569 1.000 39.00758 ? 514 HOH A O   1 
HETATM 4631 O  O   . HOH D 3 .   ? 16.28319  -9.18941  -29.42540 1.000 45.84038 ? 515 HOH A O   1 
HETATM 4632 O  O   . HOH D 3 .   ? 3.01565   0.35896   -28.43074 1.000 41.98699 ? 516 HOH A O   1 
HETATM 4633 O  O   . HOH D 3 .   ? -11.93829 -3.64053  -18.10465 1.000 35.69945 ? 517 HOH A O   1 
HETATM 4634 O  O   . HOH D 3 .   ? -15.68387 14.54675  -27.44736 1.000 38.97954 ? 518 HOH A O   1 
HETATM 4635 O  O   . HOH D 3 .   ? 11.95445  -4.65948  -37.25457 1.000 37.46165 ? 519 HOH A O   1 
HETATM 4636 O  O   . HOH D 3 .   ? -2.43726  11.46703  -22.52111 1.000 34.54031 ? 520 HOH A O   1 
HETATM 4637 O  O   . HOH D 3 .   ? -10.00011 0.87044   -39.56719 1.000 38.74305 ? 521 HOH A O   1 
HETATM 4638 O  O   . HOH D 3 .   ? 20.80391  0.38318   -43.76048 1.000 29.70804 ? 522 HOH A O   1 
HETATM 4639 O  O   . HOH D 3 .   ? 5.67895   6.41410   -27.98260 1.000 27.95683 ? 523 HOH A O   1 
HETATM 4640 O  O   . HOH D 3 .   ? 15.37516  -0.62018  -42.04297 1.000 36.74908 ? 524 HOH A O   1 
HETATM 4641 O  O   . HOH D 3 .   ? 0.76385   15.25812  -39.98241 1.000 43.10223 ? 525 HOH A O   1 
HETATM 4642 O  O   . HOH D 3 .   ? -6.45631  -2.17320  -44.40015 1.000 45.56698 ? 526 HOH A O   1 
HETATM 4643 O  O   . HOH D 3 .   ? -24.64427 3.31644   -29.79049 1.000 34.57167 ? 527 HOH A O   1 
HETATM 4644 O  O   . HOH D 3 .   ? -17.67515 9.60528   -37.76938 1.000 42.10602 ? 528 HOH A O   1 
HETATM 4645 O  O   . HOH D 3 .   ? -16.59786 -10.03685 -21.61574 1.000 40.00278 ? 529 HOH A O   1 
HETATM 4646 O  O   . HOH D 3 .   ? 1.02478   11.92270  -31.84342 1.000 30.20495 ? 530 HOH A O   1 
HETATM 4647 O  O   . HOH D 3 .   ? 8.16263   12.14332  -47.45424 1.000 42.24019 ? 531 HOH A O   1 
HETATM 4648 O  O   . HOH D 3 .   ? 0.77819   8.24146   -22.81396 1.000 36.90320 ? 532 HOH A O   1 
HETATM 4649 O  O   . HOH D 3 .   ? 20.26878  4.38172   -40.78148 1.000 33.57901 ? 533 HOH A O   1 
HETATM 4650 O  O   . HOH D 3 .   ? -7.41641  -4.53844  -27.18117 1.000 34.07822 ? 534 HOH A O   1 
HETATM 4651 O  O   . HOH D 3 .   ? -1.48907  2.73853   -17.75107 1.000 42.69235 ? 535 HOH A O   1 
HETATM 4652 O  O   . HOH D 3 .   ? 5.09651   16.93192  -44.91016 1.000 49.58474 ? 536 HOH A O   1 
HETATM 4653 O  O   . HOH D 3 .   ? 14.36941  15.85267  -46.05269 1.000 43.56304 ? 537 HOH A O   1 
HETATM 4654 O  O   . HOH D 3 .   ? 16.354    7.708     -52.791   1.000 40.09172 ? 538 HOH A O   1 
HETATM 4655 O  O   . HOH D 3 .   ? -36.52198 9.87320   -32.22253 1.000 43.14075 ? 539 HOH A O   1 
HETATM 4656 O  O   . HOH D 3 .   ? -1.84011  1.18826   -19.85550 1.000 43.62439 ? 540 HOH A O   1 
HETATM 4657 O  O   . HOH D 3 .   ? 16.08927  -0.11148  -21.15971 1.000 41.90995 ? 541 HOH A O   1 
HETATM 4658 O  O   . HOH D 3 .   ? 6.28685   -1.44115  -32.31280 1.000 47.35841 ? 542 HOH A O   1 
HETATM 4659 O  O   . HOH D 3 .   ? 16.33436  17.29225  -38.37423 1.000 37.61937 ? 543 HOH A O   1 
HETATM 4660 O  O   . HOH D 3 .   ? 3.87494   9.43119   -37.48046 1.000 31.74712 ? 544 HOH A O   1 
HETATM 4661 O  O   . HOH D 3 .   ? -13.05632 9.41043   -37.98390 1.000 41.46455 ? 545 HOH A O   1 
HETATM 4662 O  O   . HOH D 3 .   ? -20.88355 8.23842   -36.04435 1.000 33.35625 ? 546 HOH A O   1 
HETATM 4663 O  O   . HOH D 3 .   ? 18.784    6.344     -48.465   1.000 37.90444 ? 547 HOH A O   1 
HETATM 4664 O  O   . HOH D 3 .   ? -29.70598 -0.36114  -41.94859 1.000 36.65321 ? 548 HOH A O   1 
HETATM 4665 O  O   . HOH D 3 .   ? 22.35203  15.92036  -39.86102 1.000 48.54806 ? 549 HOH A O   1 
HETATM 4666 O  O   . HOH D 3 .   ? -21.17492 6.12431   -37.25361 1.000 33.31056 ? 550 HOH A O   1 
HETATM 4667 O  O   . HOH D 3 .   ? 1.85688   7.86913   -20.08934 1.000 38.72608 ? 551 HOH A O   1 
HETATM 4668 O  O   . HOH D 3 .   ? -5.53149  15.07811  -30.84440 1.000 35.67807 ? 552 HOH A O   1 
HETATM 4669 O  O   . HOH D 3 .   ? -28.11846 13.76288  -34.38085 1.000 38.56211 ? 553 HOH A O   1 
HETATM 4670 O  O   . HOH D 3 .   ? -30.76551 4.48577   -37.23752 1.000 43.42826 ? 554 HOH A O   1 
HETATM 4671 O  O   . HOH D 3 .   ? -2.51316  18.34616  -15.59946 1.000 50.86736 ? 555 HOH A O   1 
HETATM 4672 O  O   . HOH D 3 .   ? 16.24302  18.79899  -36.29436 1.000 42.84680 ? 556 HOH A O   1 
HETATM 4673 O  O   . HOH D 3 .   ? -9.82517  11.31914  -35.68804 1.000 40.31562 ? 557 HOH A O   1 
HETATM 4674 O  O   . HOH D 3 .   ? -21.19050 -5.47974  -43.61948 1.000 42.77289 ? 558 HOH A O   1 
HETATM 4675 O  O   . HOH D 3 .   ? 22.68134  11.79418  -24.04375 1.000 46.28898 ? 559 HOH A O   1 
HETATM 4676 O  O   . HOH D 3 .   ? 8.95341   2.82422   -21.83359 1.000 47.70975 ? 560 HOH A O   1 
HETATM 4677 O  O   . HOH D 3 .   ? -21.64331 16.39448  -35.73266 1.000 49.53207 ? 561 HOH A O   1 
HETATM 4678 O  O   . HOH D 3 .   ? 12.44210  20.64013  -35.92986 1.000 44.12968 ? 562 HOH A O   1 
HETATM 4679 O  O   . HOH D 3 .   ? -22.04681 -0.64150  -43.20011 1.000 53.69406 ? 563 HOH A O   1 
HETATM 4680 O  O   . HOH D 3 .   ? -22.83413 4.50133   -9.58422  1.000 44.03540 ? 564 HOH A O   1 
HETATM 4681 O  O   . HOH D 3 .   ? -11.34178 -4.35496  -14.83229 1.000 39.70433 ? 565 HOH A O   1 
HETATM 4682 O  O   . HOH D 3 .   ? -14.38841 10.86190  -6.80818  1.000 48.54601 ? 566 HOH A O   1 
HETATM 4683 O  O   . HOH D 3 .   ? -0.16151  1.89465   -15.53125 1.000 34.87146 ? 567 HOH A O   1 
HETATM 4684 O  O   . HOH D 3 .   ? -13.48215 -0.57101  -7.21157  1.000 47.38475 ? 568 HOH A O   1 
HETATM 4685 O  O   . HOH D 3 .   ? -11.73422 12.10241  -37.59261 1.000 43.94459 ? 569 HOH A O   1 
HETATM 4686 O  O   . HOH D 3 .   ? 1.79662   15.67247  -29.21480 1.000 47.37373 ? 570 HOH A O   1 
HETATM 4687 O  O   . HOH D 3 .   ? -4.82257  2.85516   -41.58900 1.000 51.30430 ? 571 HOH A O   1 
HETATM 4688 O  O   . HOH D 3 .   ? -24.24714 2.69628   -9.41627  1.000 46.52427 ? 572 HOH A O   1 
HETATM 4689 O  O   . HOH D 3 .   ? -37.673   6.467     -39.931   1.000 45.02989 ? 573 HOH A O   1 
HETATM 4690 O  O   . HOH D 3 .   ? -1.03112  8.07918   -43.89603 1.000 45.54499 ? 574 HOH A O   1 
HETATM 4691 O  O   . HOH D 3 .   ? -21.33044 9.32013   -8.36025  1.000 49.29348 ? 575 HOH A O   1 
HETATM 4692 O  O   . HOH D 3 .   ? -22.27714 18.27945  -26.41794 1.000 40.02874 ? 576 HOH A O   1 
HETATM 4693 O  O   . HOH D 3 .   ? -24.91718 8.04481   -37.64379 1.000 45.18942 ? 577 HOH A O   1 
HETATM 4694 O  O   . HOH D 3 .   ? -10.32417 -11.71174 -29.48581 1.000 51.39161 ? 578 HOH A O   1 
HETATM 4695 O  O   . HOH D 3 .   ? -0.12800  19.49088  -18.59690 1.000 53.57311 ? 579 HOH A O   1 
HETATM 4696 O  O   . HOH D 3 .   ? 11.79255  -3.95218  -32.06060 1.000 46.21234 ? 580 HOH A O   1 
HETATM 4697 O  O   . HOH D 3 .   ? 1.09093   -2.87274  -34.36064 1.000 53.85433 ? 581 HOH A O   1 
HETATM 4698 O  O   . HOH D 3 .   ? 21.00995  11.16430  -47.32532 1.000 38.74309 ? 582 HOH A O   1 
HETATM 4699 O  O   . HOH D 3 .   ? 20.78748  13.69723  -46.64539 1.000 43.69545 ? 583 HOH A O   1 
HETATM 4700 O  O   . HOH D 3 .   ? 0.01023   14.33703  -31.17093 1.000 56.57541 ? 584 HOH A O   1 
HETATM 4701 O  O   . HOH D 3 .   ? 3.07391   19.32500  -44.07350 1.000 50.64051 ? 585 HOH A O   1 
HETATM 4702 O  O   . HOH E 3 .   ? 11.20846  -0.21960  11.58773  1.000 35.60977 ? 401 HOH B O   1 
HETATM 4703 O  O   . HOH E 3 .   ? 12.41175  -11.05137 -2.21434  1.000 38.44877 ? 402 HOH B O   1 
HETATM 4704 O  O   . HOH E 3 .   ? 5.14695   -6.66684  -16.10203 1.000 45.69075 ? 403 HOH B O   1 
HETATM 4705 O  O   . HOH E 3 .   ? 7.99944   -2.28340  -9.83131  1.000 32.64752 ? 404 HOH B O   1 
HETATM 4706 O  O   . HOH E 3 .   ? 0.17969   9.65887   -3.71720  1.000 37.89399 ? 405 HOH B O   1 
HETATM 4707 O  O   . HOH E 3 .   ? 12.00657  -0.09786  -1.04482  1.000 28.46438 ? 406 HOH B O   1 
HETATM 4708 O  O   . HOH E 3 .   ? -2.10711  -2.39672  -0.38141  1.000 33.37468 ? 407 HOH B O   1 
HETATM 4709 O  O   . HOH E 3 .   ? 1.55426   0.10471   5.41251   1.000 31.89367 ? 408 HOH B O   1 
HETATM 4710 O  O   . HOH E 3 .   ? -1.10669  -5.57579  -11.86274 1.000 33.80890 ? 409 HOH B O   1 
HETATM 4711 O  O   . HOH E 3 .   ? 1.24058   -10.46429 -29.38329 1.000 43.17984 ? 410 HOH B O   1 
HETATM 4712 O  O   . HOH E 3 .   ? 12.359    6.738     14.110    1.000 39.06071 ? 411 HOH B O   1 
HETATM 4713 O  O   . HOH E 3 .   ? -3.15799  -8.83322  -6.71392  1.000 33.47107 ? 412 HOH B O   1 
HETATM 4714 O  O   . HOH E 3 .   ? -2.87312  -4.83131  -7.39073  1.000 30.06063 ? 413 HOH B O   1 
HETATM 4715 O  O   . HOH E 3 .   ? -5.06119  -6.58649  -13.78782 1.000 34.72935 ? 414 HOH B O   1 
HETATM 4716 O  O   . HOH E 3 .   ? 2.76095   -12.41714 -6.78357  1.000 36.66897 ? 415 HOH B O   1 
HETATM 4717 O  O   . HOH E 3 .   ? -2.84857  -4.33181  -13.82285 1.000 32.36103 ? 416 HOH B O   1 
HETATM 4718 O  O   . HOH E 3 .   ? 9.25812   -31.64549 -8.43327  1.000 55.88416 ? 417 HOH B O   1 
HETATM 4719 O  O   . HOH E 3 .   ? -10.87763 5.61580   -5.82188  1.000 36.66560 ? 418 HOH B O   1 
HETATM 4720 O  O   . HOH E 3 .   ? -13.99957 4.72974   1.43503   1.000 43.10659 ? 419 HOH B O   1 
HETATM 4721 O  O   . HOH E 3 .   ? 2.69746   -10.80121 -14.85696 1.000 32.56328 ? 420 HOH B O   1 
HETATM 4722 O  O   . HOH E 3 .   ? 7.32487   -16.89147 -8.42876  1.000 43.90043 ? 421 HOH B O   1 
HETATM 4723 O  O   . HOH E 3 .   ? -0.08629  -6.27176  6.13862   1.000 46.18840 ? 422 HOH B O   1 
HETATM 4724 O  O   . HOH E 3 .   ? 12.90708  9.46514   5.27337   1.000 35.17036 ? 423 HOH B O   1 
HETATM 4725 O  O   . HOH E 3 .   ? 11.84859  -35.74577 -15.12079 1.000 42.97247 ? 424 HOH B O   1 
HETATM 4726 O  O   . HOH E 3 .   ? 16.20895  -2.84563  -8.96022  1.000 39.79151 ? 425 HOH B O   1 
HETATM 4727 O  O   . HOH E 3 .   ? 16.43674  3.94629   7.63588   1.000 35.76504 ? 426 HOH B O   1 
HETATM 4728 O  O   . HOH E 3 .   ? 12.37055  -5.72062  3.69202   1.000 35.77338 ? 427 HOH B O   1 
HETATM 4729 O  O   . HOH E 3 .   ? 5.59593   -0.75463  12.51590  1.000 36.75165 ? 428 HOH B O   1 
HETATM 4730 O  O   . HOH E 3 .   ? 8.78381   11.12553  17.97098  1.000 40.70252 ? 429 HOH B O   1 
HETATM 4731 O  O   . HOH E 3 .   ? 7.64816   -7.77959  2.85901   1.000 36.30382 ? 430 HOH B O   1 
HETATM 4732 O  O   . HOH E 3 .   ? -14.05194 -10.76184 -23.61164 1.000 46.63316 ? 431 HOH B O   1 
HETATM 4733 O  O   . HOH E 3 .   ? 17.92068  -5.64766  -2.36657  1.000 35.73763 ? 432 HOH B O   1 
HETATM 4734 O  O   . HOH E 3 .   ? -8.22954  -22.48075 -23.64097 1.000 44.98571 ? 433 HOH B O   1 
HETATM 4735 O  O   . HOH E 3 .   ? -1.30778  -7.59189  -4.94318  1.000 34.10796 ? 434 HOH B O   1 
HETATM 4736 O  O   . HOH E 3 .   ? 9.63654   4.78470   16.15043  1.000 35.49512 ? 435 HOH B O   1 
HETATM 4737 O  O   . HOH E 3 .   ? -11.282   3.392     8.050     1.000 42.43467 ? 436 HOH B O   1 
HETATM 4738 O  O   . HOH E 3 .   ? 11.42422  -10.60876 -17.76391 1.000 49.58275 ? 437 HOH B O   1 
HETATM 4739 O  O   . HOH E 3 .   ? 9.03156   2.06951   16.22415  1.000 40.37415 ? 438 HOH B O   1 
HETATM 4740 O  O   . HOH E 3 .   ? -9.33465  -11.58233 -8.27231  1.000 48.13700 ? 439 HOH B O   1 
HETATM 4741 O  O   . HOH E 3 .   ? -3.34278  -5.97193  -25.45380 1.000 45.15885 ? 440 HOH B O   1 
HETATM 4742 O  O   . HOH E 3 .   ? 0.95938   -7.28387  -21.71730 1.000 44.87325 ? 441 HOH B O   1 
HETATM 4743 O  O   . HOH E 3 .   ? -0.41765  -1.14662  -20.93332 1.000 31.60843 ? 442 HOH B O   1 
HETATM 4744 O  O   . HOH E 3 .   ? 9.92836   -7.65327  4.63770   1.000 40.33300 ? 443 HOH B O   1 
HETATM 4745 O  O   . HOH E 3 .   ? 13.024    -2.956    7.692     1.000 33.90569 ? 444 HOH B O   1 
HETATM 4746 O  O   . HOH E 3 .   ? 1.79593   -1.32790  7.47506   1.000 36.49038 ? 445 HOH B O   1 
HETATM 4747 O  O   . HOH E 3 .   ? 12.17970  -5.95797  6.75310   1.000 42.75357 ? 446 HOH B O   1 
HETATM 4748 O  O   . HOH E 3 .   ? -6.53500  -3.92529  -11.17189 1.000 28.62159 ? 447 HOH B O   1 
HETATM 4749 O  O   . HOH E 3 .   ? 7.51776   -15.00650 -6.12221  1.000 46.65578 ? 448 HOH B O   1 
HETATM 4750 O  O   . HOH E 3 .   ? -3.18449  16.04641  -14.12356 1.000 50.06637 ? 449 HOH B O   1 
HETATM 4751 O  O   . HOH E 3 .   ? -11.89573 -2.21806  -7.10084  1.000 46.33173 ? 450 HOH B O   1 
HETATM 4752 O  O   . HOH E 3 .   ? -9.12657  -20.02491 -22.77712 1.000 54.53759 ? 451 HOH B O   1 
HETATM 4753 O  O   . HOH E 3 .   ? 16.35125  11.92187  -0.54876  1.000 62.16511 ? 452 HOH B O   1 
HETATM 4754 O  O   . HOH E 3 .   ? 17.16077  10.15240  0.66668   1.000 50.66059 ? 453 HOH B O   1 
# 
